id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eurjchem-527	Bandaru, Madhav; Sabbavarapu, Narayana Murthy; Pavan, Anil Kumar Bandam Santosh; Akula, Ashwan Kumar; Durga, Nageswar Yadavalli Venkata	Simple and straight forward synthesis of 2,4-disubstituted quinazolines in aqueous medium	2012	6	.pdf	application/pdf	4916	318	82	MS (ESI, m/z): 265 [M+H]+. 254 Bandaru et al. / European Journal of Chemistry 3 (2) (2012) 252‐257 Scheme 1 Scheme 2 Table 1. Synthesis of quinazolines from various 2‐aminoarylcarbonyl compounds.a Entry 2‐Aminocarbonyl compounds Benzaldehyde Product Yield b 1 NH2 Me O 1a 3a 62 [46] 2 NH2 Me O OMe OMe 1b CHO N N Me Ph OMe OMe 3b 59* 3 NH2 H O Cl 1c CHO N N Ph Cl 3c 60 [46] 4 NH2 Me O O O 1d CHO N N Me Ph O O 3d 61 * 5 NH2 Ph O 1e CHO N N Ph Ph 3e 63 [46] 6 NH2 O Cl 1f CHO N N Ph Ph Cl 3f 67 [46] 7 NH2 O Cl Cl 1g CHO N N Ph Cl Cl 3g 65 * 8 NH2 O Br 1h CHO N N Ph PhBr 3h 62 * 9 NH2 O NO2 1i CHO N N Ph Ph NO2 3i 25 [47] a Reaction conditions: Substituted 2‐aminoarylcarbonyl compounds (1.00 eq), benzaldehyde (1.25 eq), AcONH4 (10 eq) in H2O at 75 oC. b Yields in percentage. Webber, S. E.; Bleckman, T. M.; Attard, J.; Deal, J. G.; Kathardekar, V.; Welsh, K. M.; Webber, S.; Janson, C. A.; Matthews, D. A.; Smith, W. W. J. Med. Chem. 1993, 36, 733‐746.	cache/eurjchem-527.pdf	txt/eurjchem-527.txt