id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eurjchem-677	Fawzy, Naglaa; Ghobashy, Madeha Othman Ibrahim; El-Ziaty, Ahmed Kamel	Synthesis and antimicrobial evaluation of some new quinazolin-4(3H)-one derivatives	2012	5	.pdf	application/pdf	3642	204	59	Ring opening of compound 3 with secondary amines gave the corresponding amid derivatives 5a,b. In continuation of our interest in synthesis and studying the reaction behavior of benzoxazinones and quinazolinones [16‐20] we reported herein the behaviour of the benzoxazinone derivative, 3, with some active methylene compounds as carbone nucleophile, so the benzoxazinone derivative, 3, was reacted with ethyl cyanoacetate and/or malononitrile in pyridine to give 2‐(2‐(anthracen‐9‐yl)‐1‐ benzamidovinyl)‐4‐oxo‐3,4‐dihydro‐quinoline‐3‐carboxylic acid, 6, via ring opening and ring closure of the benoxazinone derivative, 3, followed by hydrolysis of the cyano or the ethylester group to the carboxylic group. The reaction mixture was poured onto warm water, the solid formed was collected by filtration, dried and recrystallized from 1,4‐dioxane to give compound 1 as orange crystals (Scheme 1).	cache/eurjchem-677.pdf	txt/eurjchem-677.txt