id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eurjchem-844	El-Bagary, Ramzia Ismail; Elkady, Ehab Farouk; Ayoub, Bassam Mahfouz	Development and validation of a reversed phase liquid chromatographic method for the determination of three Gliptins and Metformin in the presence of Metformin impurity (1-cyanoguanidine)	2013	6	.pdf	application/pdf	4251	227	55	Item Sitagliptin Vildagliptin Saxagliptin Retention time 6.0 7.1 6.5 Wavelength of detection, nm 210 210 210 Range of linearity, μg/mL 5‐200 5‐200 0.5‐80 Regression equation Area×10‐5 = 0.1013 Cμg/mL+ 0.0736 Area×10‐5 = 0.1126 Cμg/mL + 0.4040 Area×10‐5 = 0.1495 Cμg/mL + 0.0114 Regression coefficient (r2) 0.9998 0.9996 0.9987 LOD, μg/mL 1.48 0.53 0.10 LOQ, μg/mL 4.94 1.78 0.42 Sb 1.16×10‐4 1.6×10‐4 1.8×10‐4 Sa 0.17 0.22 0.25 Confidence limit of the slope 0.1013±0.02 0.1126±0.02 0.1495±0.04 Confidence limit of the intercept 0.0736±0.09×10‐4 0.4040±0.65×10‐4 0.0114±0.02×10‐4 Standard error of the estimation 0.19 0.27 0.31 Intraday %R.S.D. 0.29‐0.58 0.21‐0.42 0.43‐0.68 Interday %R.S.D. 0.31‐1.14 0.23‐0.92 0.56‐1.31 Drug in laboratory mixture 100.32±1.44 100.17±1.41 100.01±1.51 Drug in dosage form 100.13±1.15 99.95±1.60 99.85±1.68 Drug added 100.52±1.21 100.24±1.65 99.53±1.46 * LOD: Method development Different chromatographic systems including different C18 columns and different mobile phases at different pH values were attempted.	cache/eurjchem-844.pdf	txt/eurjchem-844.txt