id	sid	tid	token	lemma	pos
eurjchem-1058	1	1	untitled	untitle	VERB
eurjchem-1058	1	2	european	european	PROPN
eurjchem-1058	1	3	journal	journal	PROPN
eurjchem-1058	1	4	of	of	ADP
eurjchem-1058	1	5	chemistry	chemistry	NOUN
eurjchem-1058	1	6	5	5	NUM
eurjchem-1058	1	7	(	(	PUNCT
eurjchem-1058	1	8	3	3	NUM
eurjchem-1058	1	9	)	)	PUNCT
eurjchem-1058	1	10	(	(	PUNCT
eurjchem-1058	1	11	2014	2014	NUM
eurjchem-1058	1	12	)	)	PUNCT
eurjchem-1058	1	13	469‐474	469‐474	PROPN
eurjchem-1058	1	14	european	european	PROPN
eurjchem-1058	1	15	journal	journal	PROPN
eurjchem-1058	1	16	of	of	ADP
eurjchem-1058	1	17	chemistry	chemistry	NOUN
eurjchem-1058	1	18	issn	issn	PROPN
eurjchem-1058	1	19	2153‐2249	2153‐2249	PROPN
eurjchem-1058	1	20	(	(	PUNCT
eurjchem-1058	1	21	print	print	NOUN
eurjchem-1058	1	22	)	)	PUNCT
eurjchem-1058	1	23	/	/	SYM
eurjchem-1058	1	24	issn	issn	PROPN
eurjchem-1058	1	25	2153‐2257	2153‐2257	NUM
eurjchem-1058	1	26	(	(	PUNCT
eurjchem-1058	1	27	online	online	ADJ
eurjchem-1058	1	28	)	)	PUNCT
eurjchem-1058	1	29			NOUN
eurjchem-1058	1	30	2014	2014	NUM
eurjchem-1058	2	1	eurjchem	eurjchem	PROPN
eurjchem-1058	2	2	publishing	publish	VERB
eurjchem-1058	2	3	‐	‐	NOUN
eurjchem-1058	2	4	printed	print	VERB
eurjchem-1058	2	5	in	in	ADP
eurjchem-1058	2	6	the	the	DET
eurjchem-1058	2	7	usa	usa	PROPN
eurjchem-1058	2	8	http://dx.doi.org/10.5155/eurjchem.5.3.469‐474.1058	http://dx.doi.org/10.5155/eurjchem.5.3.469‐474.1058	PROPN
eurjchem-1058	2	9	european	european	PROPN
eurjchem-1058	2	10	journal	journal	PROPN
eurjchem-1058	2	11	of	of	ADP
eurjchem-1058	2	12	chemistry	chemistry	PROPN
eurjchem-1058	2	13	journal	journal	PROPN
eurjchem-1058	2	14	homepage	homepage	NOUN
eurjchem-1058	2	15	:	:	PUNCT
eurjchem-1058	2	16	www.eurjchem.com	www.eurjchem.com	X
eurjchem-1058	2	17	development	development	NOUN
eurjchem-1058	2	18	and	and	CCONJ
eurjchem-1058	2	19	validation	validation	NOUN
eurjchem-1058	2	20	of	of	ADP
eurjchem-1058	2	21	a	a	DET
eurjchem-1058	2	22	new	new	ADJ
eurjchem-1058	2	23	rp‐hplc	rp‐hplc	PROPN
eurjchem-1058	2	24	method	method	NOUN
eurjchem-1058	2	25	for	for	ADP
eurjchem-1058	2	26	the	the	DET
eurjchem-1058	2	27	determination	determination	NOUN
eurjchem-1058	2	28	of	of	ADP
eurjchem-1058	2	29	process	process	NOUN
eurjchem-1058	2	30	related	relate	VERB
eurjchem-1058	2	31	impurities	impurity	NOUN
eurjchem-1058	2	32	in	in	ADP
eurjchem-1058	2	33	pioglitazone	pioglitazone	NOUN
eurjchem-1058	2	34	hydrochloride	hydrochloride	NOUN
eurjchem-1058	2	35	venkata	venkata	PROPN
eurjchem-1058	2	36	raj	raj	PROPN
eurjchem-1058	2	37	kumar	kumar	PROPN
eurjchem-1058	2	38	prava	prava	PROPN
eurjchem-1058	2	39	a	a	PROPN
eurjchem-1058	2	40	,	,	PUNCT
eurjchem-1058	2	41	*	*	PUNCT
eurjchem-1058	2	42	and	and	CCONJ
eurjchem-1058	2	43	ganapaty	ganapaty	NOUN
eurjchem-1058	2	44	seru	seru	PROPN
eurjchem-1058	2	45	b	b	PROPN
eurjchem-1058	2	46	a	a	DET
eurjchem-1058	2	47	department	department	NOUN
eurjchem-1058	2	48	of	of	ADP
eurjchem-1058	2	49	pharmaceutical	pharmaceutical	NOUN
eurjchem-1058	2	50	sciences	sciences	PROPN
eurjchem-1058	2	51	,	,	PUNCT
eurjchem-1058	2	52	andhra	andhra	PROPN
eurjchem-1058	2	53	university	university	PROPN
eurjchem-1058	2	54	college	college	PROPN
eurjchem-1058	2	55	of	of	ADP
eurjchem-1058	2	56	pharmaceutical	pharmaceutical	NOUN
eurjchem-1058	2	57	sciences	sciences	PROPN
eurjchem-1058	2	58	,	,	PUNCT
eurjchem-1058	2	59	andhra	andhra	PROPN
eurjchem-1058	2	60	university	university	PROPN
eurjchem-1058	2	61	,	,	PUNCT
eurjchem-1058	2	62	visakhapatnam	visakhapatnam	PROPN
eurjchem-1058	2	63	,	,	PUNCT
eurjchem-1058	2	64	530003	530003	NUM
eurjchem-1058	2	65	,	,	PUNCT
eurjchem-1058	2	66	andhra	andhra	PROPN
eurjchem-1058	2	67	pradesh	pradesh	PROPN
eurjchem-1058	2	68	,	,	PUNCT
eurjchem-1058	2	69	india	india	PROPN
eurjchem-1058	2	70	b	b	PROPN
eurjchem-1058	2	71	gitam	gitam	PROPN
eurjchem-1058	2	72	institute	institute	PROPN
eurjchem-1058	2	73	of	of	ADP
eurjchem-1058	2	74	pharmacy	pharmacy	NOUN
eurjchem-1058	2	75	,	,	PUNCT
eurjchem-1058	2	76	gitam	gitam	NOUN
eurjchem-1058	2	77	university	university	NOUN
eurjchem-1058	2	78	,	,	PUNCT
eurjchem-1058	2	79	rushikonda	rushikonda	ADJ
eurjchem-1058	2	80	,	,	PUNCT
eurjchem-1058	2	81	visakhapatnam	visakhapatnam	PROPN
eurjchem-1058	2	82	,	,	PUNCT
eurjchem-1058	2	83	530045	530045	NUM
eurjchem-1058	2	84	,	,	PUNCT
eurjchem-1058	2	85	andhra	andhra	PROPN
eurjchem-1058	2	86	pradesh	pradesh	PROPN
eurjchem-1058	2	87	,	,	PUNCT
eurjchem-1058	2	88	india	india	PROPN
eurjchem-1058	2	89	*	*	PUNCT
eurjchem-1058	2	90	corresponding	correspond	VERB
eurjchem-1058	2	91	author	author	NOUN
eurjchem-1058	2	92	at	at	ADP
eurjchem-1058	2	93	:	:	PUNCT
eurjchem-1058	2	94	department	department	NOUN
eurjchem-1058	2	95	of	of	ADP
eurjchem-1058	2	96	pharmaceutical	pharmaceutical	NOUN
eurjchem-1058	2	97	sciences	sciences	PROPN
eurjchem-1058	2	98	,	,	PUNCT
eurjchem-1058	2	99	andhra	andhra	PROPN
eurjchem-1058	2	100	university	university	PROPN
eurjchem-1058	2	101	college	college	PROPN
eurjchem-1058	2	102	of	of	ADP
eurjchem-1058	2	103	pharmaceutical	pharmaceutical	NOUN
eurjchem-1058	2	104	sciences	sciences	PROPN
eurjchem-1058	2	105	,	,	PUNCT
eurjchem-1058	2	106	andhra	andhra	PROPN
eurjchem-1058	2	107	university	university	PROPN
eurjchem-1058	2	108	,	,	PUNCT
eurjchem-1058	2	109	visakhapatnam	visakhapatnam	PROPN
eurjchem-1058	2	110	,	,	PUNCT
eurjchem-1058	2	111	530003	530003	NUM
eurjchem-1058	2	112	,	,	PUNCT
eurjchem-1058	2	113	andhra	andhra	PROPN
eurjchem-1058	2	114	pradesh	pradesh	PROPN
eurjchem-1058	2	115	,	,	PUNCT
eurjchem-1058	2	116	india	india	PROPN
eurjchem-1058	2	117	.	.	PUNCT
eurjchem-1058	3	1	tel	tel	PROPN
eurjchem-1058	3	2	.	.	PUNCT
eurjchem-1058	3	3	:	:	PUNCT
eurjchem-1058	4	1	+91.94.90235602	+91.94.90235602	X
eurjchem-1058	4	2	.	.	PUNCT
eurjchem-1058	5	1	fax	fax	NOUN
eurjchem-1058	5	2	:	:	PUNCT
eurjchem-1058	5	3	+91.94.90235602	+91.94.90235602	NUM
eurjchem-1058	5	4	.	.	PUNCT
eurjchem-1058	5	5	e‐mail	e‐mail	PUNCT
eurjchem-1058	6	1	address	address	NOUN
eurjchem-1058	6	2	:	:	PUNCT
eurjchem-1058	6	3	pravavenkatarajkumar@gmail.com	pravavenkatarajkumar@gmail.com	X
eurjchem-1058	6	4	(	(	PUNCT
eurjchem-1058	6	5	v.r.k	v.r.k	X
eurjchem-1058	6	6	.	.	PUNCT
eurjchem-1058	6	7	prava	prava	PROPN
eurjchem-1058	6	8	)	)	PUNCT
eurjchem-1058	6	9	.	.	PUNCT
eurjchem-1058	7	1	article	article	NOUN
eurjchem-1058	7	2	information	information	PROPN
eurjchem-1058	7	3	abstract	abstract	ADJ
eurjchem-1058	7	4	doi	doi	NOUN
eurjchem-1058	7	5	:	:	PUNCT
eurjchem-1058	7	6	10.5155	10.5155	NUM
eurjchem-1058	7	7	/	/	SYM
eurjchem-1058	7	8	eurjchem.5.3.469‐474.1058	eurjchem.5.3.469‐474.1058	NUM
eurjchem-1058	7	9	received	receive	VERB
eurjchem-1058	7	10	:	:	PUNCT
eurjchem-1058	7	11	22	22	NUM
eurjchem-1058	7	12	march	march	NOUN
eurjchem-1058	7	13	2014	2014	NUM
eurjchem-1058	7	14	received	receive	VERB
eurjchem-1058	7	15	in	in	ADP
eurjchem-1058	7	16	revised	revise	VERB
eurjchem-1058	7	17	form	form	NOUN
eurjchem-1058	7	18	:	:	PUNCT
eurjchem-1058	7	19	03	03	NUM
eurjchem-1058	7	20	may	may	AUX
eurjchem-1058	7	21	2014	2014	NUM
eurjchem-1058	7	22	accepted	accept	VERB
eurjchem-1058	7	23	:	:	PUNCT
eurjchem-1058	7	24	04	04	NUM
eurjchem-1058	7	25	may	may	AUX
eurjchem-1058	7	26	2014	2014	NUM
eurjchem-1058	7	27	online	online	NOUN
eurjchem-1058	7	28	:	:	PUNCT
eurjchem-1058	7	29	30	30	NUM
eurjchem-1058	7	30	september	september	PROPN
eurjchem-1058	7	31	2014	2014	NUM
eurjchem-1058	7	32	keywords	keyword	VERB
eurjchem-1058	7	33	a	a	DET
eurjchem-1058	7	34	reversed	reverse	VERB
eurjchem-1058	7	35	phase	phase	NOUN
eurjchem-1058	7	36	high	high	ADJ
eurjchem-1058	7	37	performance	performance	NOUN
eurjchem-1058	7	38	liquid	liquid	ADJ
eurjchem-1058	7	39	chromatographic	chromatographic	ADJ
eurjchem-1058	7	40	method	method	NOUN
eurjchem-1058	7	41	for	for	ADP
eurjchem-1058	7	42	the	the	DET
eurjchem-1058	7	43	determination	determination	NOUN
eurjchem-1058	7	44	of	of	ADP
eurjchem-1058	7	45	process	process	NOUN
eurjchem-1058	7	46	related	relate	VERB
eurjchem-1058	7	47	impurities	impurity	NOUN
eurjchem-1058	7	48	in	in	ADP
eurjchem-1058	7	49	pioglitazone	pioglitazone	NOUN
eurjchem-1058	7	50	hydrochloride	hydrochloride	NOUN
eurjchem-1058	7	51	was	be	AUX
eurjchem-1058	7	52	developed	develop	VERB
eurjchem-1058	7	53	and	and	CCONJ
eurjchem-1058	7	54	validated	validate	VERB
eurjchem-1058	7	55	.	.	PUNCT
eurjchem-1058	8	1	high‐	high‐	NOUN
eurjchem-1058	8	2	quality	quality	NOUN
eurjchem-1058	8	3	separation	separation	NOUN
eurjchem-1058	8	4	was	be	AUX
eurjchem-1058	8	5	achieved	achieve	VERB
eurjchem-1058	8	6	on	on	ADP
eurjchem-1058	8	7	a	a	DET
eurjchem-1058	8	8	luna	luna	PROPN
eurjchem-1058	8	9	c18	c18	PROPN
eurjchem-1058	8	10	column	column	NOUN
eurjchem-1058	8	11	(	(	PUNCT
eurjchem-1058	8	12	150	150	NUM
eurjchem-1058	8	13	mm	mm	NOUN
eurjchem-1058	8	14	×	×	NOUN
eurjchem-1058	8	15	4.6	4.6	NUM
eurjchem-1058	8	16	mm	mm	NOUN
eurjchem-1058	8	17	,	,	PUNCT
eurjchem-1058	8	18	3	3	NUM
eurjchem-1058	8	19	µm	µm	NOUN
eurjchem-1058	8	20	)	)	PUNCT
eurjchem-1058	8	21	using	use	VERB
eurjchem-1058	8	22	gradient	gradient	ADJ
eurjchem-1058	8	23	elution	elution	NOUN
eurjchem-1058	8	24	at	at	ADP
eurjchem-1058	8	25	a	a	DET
eurjchem-1058	8	26	flow	flow	NOUN
eurjchem-1058	8	27	rate	rate	NOUN
eurjchem-1058	8	28	of	of	ADP
eurjchem-1058	8	29	1	1	NUM
eurjchem-1058	8	30	ml	ml	NOUN
eurjchem-1058	8	31	/	/	SYM
eurjchem-1058	8	32	min	min	NOUN
eurjchem-1058	8	33	and	and	CCONJ
eurjchem-1058	8	34	a	a	DET
eurjchem-1058	8	35	column	column	NOUN
eurjchem-1058	8	36	temperature	temperature	NOUN
eurjchem-1058	8	37	of	of	ADP
eurjchem-1058	8	38	45	45	NUM
eurjchem-1058	8	39	°	°	NOUN
eurjchem-1058	8	40	c	c	NOUN
eurjchem-1058	8	41	.	.	PUNCT
eurjchem-1058	9	1	uv	uv	NOUN
eurjchem-1058	9	2	detection	detection	NOUN
eurjchem-1058	9	3	was	be	AUX
eurjchem-1058	9	4	performed	perform	VERB
eurjchem-1058	9	5	at	at	ADP
eurjchem-1058	9	6	254	254	NUM
eurjchem-1058	9	7	nm	nm	NOUN
eurjchem-1058	9	8	.	.	PUNCT
eurjchem-1058	10	1	the	the	DET
eurjchem-1058	10	2	validation	validation	NOUN
eurjchem-1058	10	3	was	be	AUX
eurjchem-1058	10	4	performed	perform	VERB
eurjchem-1058	10	5	according	accord	VERB
eurjchem-1058	10	6	to	to	ADP
eurjchem-1058	10	7	the	the	DET
eurjchem-1058	10	8	international	international	ADJ
eurjchem-1058	10	9	conference	conference	NOUN
eurjchem-1058	10	10	on	on	ADP
eurjchem-1058	10	11	harmonization	harmonization	NOUN
eurjchem-1058	10	12	(	(	PUNCT
eurjchem-1058	10	13	ich	ich	NOUN
eurjchem-1058	10	14	)	)	PUNCT
eurjchem-1058	10	15	guidelines	guideline	NOUN
eurjchem-1058	10	16	.	.	PUNCT
eurjchem-1058	11	1	in	in	ADP
eurjchem-1058	11	2	addition	addition	NOUN
eurjchem-1058	11	3	,	,	PUNCT
eurjchem-1058	11	4	the	the	DET
eurjchem-1058	11	5	solution	solution	NOUN
eurjchem-1058	11	6	stability	stability	NOUN
eurjchem-1058	11	7	and	and	CCONJ
eurjchem-1058	11	8	method	method	NOUN
eurjchem-1058	11	9	robustness	robustness	NOUN
eurjchem-1058	11	10	were	be	AUX
eurjchem-1058	11	11	examined	examine	VERB
eurjchem-1058	11	12	.	.	PUNCT
eurjchem-1058	12	1	the	the	DET
eurjchem-1058	12	2	method	method	NOUN
eurjchem-1058	12	3	gives	give	VERB
eurjchem-1058	12	4	satisfactory	satisfactory	ADJ
eurjchem-1058	12	5	separation	separation	NOUN
eurjchem-1058	12	6	of	of	ADP
eurjchem-1058	12	7	impurities	impurity	NOUN
eurjchem-1058	12	8	of	of	ADP
eurjchem-1058	12	9	pioglitazone	pioglitazone	NOUN
eurjchem-1058	12	10	hydrochloride	hydrochloride	NOUN
eurjchem-1058	12	11	and	and	CCONJ
eurjchem-1058	12	12	so	so	ADV
eurjchem-1058	12	13	it	it	PRON
eurjchem-1058	12	14	is	be	AUX
eurjchem-1058	12	15	suitable	suitable	ADJ
eurjchem-1058	12	16	for	for	ADP
eurjchem-1058	12	17	quantification	quantification	NOUN
eurjchem-1058	12	18	of	of	ADP
eurjchem-1058	12	19	the	the	DET
eurjchem-1058	12	20	process	process	NOUN
eurjchem-1058	12	21	related	relate	VERB
eurjchem-1058	12	22	impurities	impurity	NOUN
eurjchem-1058	12	23	as	as	ADV
eurjchem-1058	12	24	well	well	ADV
eurjchem-1058	12	25	as	as	ADP
eurjchem-1058	12	26	for	for	ADP
eurjchem-1058	12	27	the	the	DET
eurjchem-1058	12	28	assay	assay	NOUN
eurjchem-1058	12	29	of	of	ADP
eurjchem-1058	12	30	the	the	DET
eurjchem-1058	12	31	active	active	ADJ
eurjchem-1058	12	32	compound	compound	NOUN
eurjchem-1058	12	33	.	.	PUNCT
eurjchem-1058	13	1	rp‐hplc	rp‐hplc	PROPN
eurjchem-1058	13	2	thiazolidinedione	thiazolidinedione	ADJ
eurjchem-1058	13	3	method	method	NOUN
eurjchem-1058	13	4	development	development	NOUN
eurjchem-1058	13	5	forced	force	VERB
eurjchem-1058	13	6	degradation	degradation	NOUN
eurjchem-1058	13	7	study	study	NOUN
eurjchem-1058	13	8	process	process	NOUN
eurjchem-1058	13	9	related	relate	VERB
eurjchem-1058	13	10	impurities	impurity	NOUN
eurjchem-1058	13	11	pioglitazone	pioglitazone	NOUN
eurjchem-1058	13	12	hydrochloride	hydrochloride	NOUN
eurjchem-1058	13	13	1	1	NUM
eurjchem-1058	13	14	.	.	PUNCT
eurjchem-1058	14	1	introduction	introduction	NOUN
eurjchem-1058	14	2	pioglitazone	pioglitazone	NOUN
eurjchem-1058	14	3	hydrochloride	hydrochloride	NOUN
eurjchem-1058	14	4	is	be	AUX
eurjchem-1058	14	5	an	an	DET
eurjchem-1058	14	6	oral	oral	ADJ
eurjchem-1058	14	7	anti	anti	ADJ
eurjchem-1058	14	8	diabetic	diabetic	ADJ
eurjchem-1058	14	9	agent	agent	NOUN
eurjchem-1058	14	10	that	that	PRON
eurjchem-1058	14	11	acts	act	VERB
eurjchem-1058	14	12	primarily	primarily	ADV
eurjchem-1058	14	13	by	by	ADP
eurjchem-1058	14	14	decreasing	decrease	VERB
eurjchem-1058	14	15	insulin	insulin	NOUN
eurjchem-1058	14	16	resistance	resistance	NOUN
eurjchem-1058	14	17	.	.	PUNCT
eurjchem-1058	15	1	pioglitazone	pioglitazone	NOUN
eurjchem-1058	15	2	hydrochloride	hydrochloride	NOUN
eurjchem-1058	15	3	is	be	AUX
eurjchem-1058	15	4	used	use	VERB
eurjchem-1058	15	5	in	in	ADP
eurjchem-1058	15	6	the	the	DET
eurjchem-1058	15	7	management	management	NOUN
eurjchem-1058	15	8	of	of	ADP
eurjchem-1058	15	9	type	type	NOUN
eurjchem-1058	15	10	2	2	NUM
eurjchem-1058	15	11	diabetes	diabetes	NOUN
eurjchem-1058	15	12	mellitus	mellitus	NOUN
eurjchem-1058	15	13	(	(	PUNCT
eurjchem-1058	15	14	also	also	ADV
eurjchem-1058	15	15	known	know	VERB
eurjchem-1058	15	16	as	as	ADP
eurjchem-1058	15	17	non‐insulin‐dependent	non‐insulin‐dependent	ADJ
eurjchem-1058	15	18	diabetes	diabetes	NOUN
eurjchem-1058	15	19	mellitus	mellitus	NOUN
eurjchem-1058	16	1	[	[	X
eurjchem-1058	16	2	niddm	niddm	X
eurjchem-1058	16	3	]	]	PUNCT
eurjchem-1058	16	4	or	or	CCONJ
eurjchem-1058	16	5	adult‐onset	adult‐onset	VERB
eurjchem-1058	16	6	diabetes	diabetes	NOUN
eurjchem-1058	16	7	)	)	PUNCT
eurjchem-1058	16	8	.	.	PUNCT
eurjchem-1058	17	1	pioglitazone	pioglitazone	NOUN
eurjchem-1058	17	2	hydrochloride	hydrochloride	NOUN
eurjchem-1058	17	3	selectively	selectively	ADV
eurjchem-1058	17	4	stimulates	stimulate	VERB
eurjchem-1058	17	5	nuclear	nuclear	ADJ
eurjchem-1058	17	6	receptor	receptor	NOUN
eurjchem-1058	17	7	peroxisone	peroxisone	NOUN
eurjchem-1058	17	8	proliferator‐activated	proliferator‐activate	VERB
eurjchem-1058	17	9	receptor	receptor	NOUN
eurjchem-1058	17	10	gamma	gamma	NOUN
eurjchem-1058	17	11	(	(	PUNCT
eurjchem-1058	17	12	ppar‐gamma	ppar‐gamma	PROPN
eurjchem-1058	17	13	)	)	PUNCT
eurjchem-1058	17	14	.	.	PUNCT
eurjchem-1058	18	1	activation	activation	NOUN
eurjchem-1058	18	2	of	of	ADP
eurjchem-1058	18	3	ppar	ppar	NOUN
eurjchem-1058	18	4	gamma	gamma	NOUN
eurjchem-1058	18	5	receptors	receptor	NOUN
eurjchem-1058	18	6	regulates	regulate	VERB
eurjchem-1058	18	7	the	the	DET
eurjchem-1058	18	8	transcription	transcription	NOUN
eurjchem-1058	18	9	of	of	ADP
eurjchem-1058	18	10	insulin‐responsive	insulin‐responsive	ADJ
eurjchem-1058	18	11	genes	gene	NOUN
eurjchem-1058	18	12	involved	involve	VERB
eurjchem-1058	18	13	in	in	ADP
eurjchem-1058	18	14	the	the	DET
eurjchem-1058	18	15	control	control	NOUN
eurjchem-1058	18	16	of	of	ADP
eurjchem-1058	18	17	glucose	glucose	NOUN
eurjchem-1058	18	18	production	production	NOUN
eurjchem-1058	18	19	,	,	PUNCT
eurjchem-1058	18	20	transport	transport	NOUN
eurjchem-1058	18	21	and	and	CCONJ
eurjchem-1058	18	22	utilization	utilization	NOUN
eurjchem-1058	18	23	.	.	PUNCT
eurjchem-1058	19	1	pioglitazone	pioglitazone	NOUN
eurjchem-1058	19	2	hydrochloride	hydrochloride	NOUN
eurjchem-1058	19	3	,	,	PUNCT
eurjchem-1058	19	4	a	a	DET
eurjchem-1058	19	5	member	member	NOUN
eurjchem-1058	19	6	of	of	ADP
eurjchem-1058	19	7	the	the	DET
eurjchem-1058	19	8	drug	drug	NOUN
eurjchem-1058	19	9	group	group	NOUN
eurjchem-1058	19	10	known	know	VERB
eurjchem-1058	19	11	as	as	ADP
eurjchem-1058	19	12	the	the	DET
eurjchem-1058	19	13	thiazolidinediones	thiazolidinedione	NOUN
eurjchem-1058	19	14	or	or	CCONJ
eurjchem-1058	19	15	"	"	PUNCT
eurjchem-1058	19	16	insulin	insulin	NOUN
eurjchem-1058	19	17	sensitizers	sensitizer	NOUN
eurjchem-1058	19	18	"	"	PUNCT
eurjchem-1058	19	19	,	,	PUNCT
eurjchem-1058	19	20	is	be	AUX
eurjchem-1058	19	21	not	not	PART
eurjchem-1058	19	22	chemically	chemically	ADV
eurjchem-1058	19	23	or	or	CCONJ
eurjchem-1058	19	24	functionally	functionally	ADV
eurjchem-1058	19	25	related	relate	VERB
eurjchem-1058	19	26	to	to	ADP
eurjchem-1058	19	27	the	the	DET
eurjchem-1058	19	28	alpha‐glucosidase	alpha‐glucosidase	NOUN
eurjchem-1058	19	29	inhibitors	inhibitor	NOUN
eurjchem-1058	19	30	,	,	PUNCT
eurjchem-1058	19	31	the	the	DET
eurjchem-1058	19	32	biguanides	biguanide	NOUN
eurjchem-1058	19	33	,	,	PUNCT
eurjchem-1058	19	34	or	or	CCONJ
eurjchem-1058	19	35	the	the	DET
eurjchem-1058	19	36	sulfonylureas	sulfonylurea	NOUN
eurjchem-1058	19	37	.	.	PUNCT
eurjchem-1058	20	1	pioglitazone	pioglitazone	NOUN
eurjchem-1058	20	2	hydrochloride	hydrochloride	NOUN
eurjchem-1058	20	3	stimulates	stimulate	VERB
eurjchem-1058	20	4	the	the	DET
eurjchem-1058	20	5	uptake	uptake	NOUN
eurjchem-1058	20	6	of	of	ADP
eurjchem-1058	20	7	glucose	glucose	NOUN
eurjchem-1058	20	8	and	and	CCONJ
eurjchem-1058	20	9	fatty	fatty	NOUN
eurjchem-1058	20	10	acids	acid	NOUN
eurjchem-1058	20	11	into	into	ADP
eurjchem-1058	20	12	cells	cell	NOUN
eurjchem-1058	20	13	by	by	ADP
eurjchem-1058	20	14	promoting	promote	VERB
eurjchem-1058	20	15	the	the	DET
eurjchem-1058	20	16	synthesis	synthesis	NOUN
eurjchem-1058	20	17	and	and	CCONJ
eurjchem-1058	20	18	expression	expression	NOUN
eurjchem-1058	20	19	of	of	ADP
eurjchem-1058	20	20	cellular	cellular	ADJ
eurjchem-1058	20	21	glucose	glucose	NOUN
eurjchem-1058	20	22	and	and	CCONJ
eurjchem-1058	20	23	fatty	fatty	NOUN
eurjchem-1058	20	24	acid	acid	NOUN
eurjchem-1058	20	25	transporters	transporter	NOUN
eurjchem-1058	20	26	[	[	X
eurjchem-1058	20	27	1	1	NUM
eurjchem-1058	20	28	]	]	PUNCT
eurjchem-1058	20	29	.	.	PUNCT
eurjchem-1058	21	1	many	many	ADJ
eurjchem-1058	21	2	studies	study	NOUN
eurjchem-1058	21	3	of	of	ADP
eurjchem-1058	21	4	pioglitazone	pioglitazone	NOUN
eurjchem-1058	21	5	demonstrated	demonstrate	VERB
eurjchem-1058	21	6	the	the	DET
eurjchem-1058	21	7	improvement	improvement	NOUN
eurjchem-1058	21	8	of	of	ADP
eurjchem-1058	21	9	glycemic	glycemic	ADJ
eurjchem-1058	21	10	control	control	NOUN
eurjchem-1058	21	11	,	,	PUNCT
eurjchem-1058	21	12	hba1c	hba1c	PROPN
eurjchem-1058	21	13	,	,	PUNCT
eurjchem-1058	21	14	fasting	fast	VERB
eurjchem-1058	21	15	plasma	plasma	NOUN
eurjchem-1058	21	16	glucose	glucose	NOUN
eurjchem-1058	21	17	levels	level	NOUN
eurjchem-1058	21	18	,	,	PUNCT
eurjchem-1058	21	19	and	and	CCONJ
eurjchem-1058	21	20	serum	serum	NOUN
eurjchem-1058	21	21	lipid	lipid	NOUN
eurjchem-1058	21	22	profiles	profile	NOUN
eurjchem-1058	21	23	[	[	X
eurjchem-1058	21	24	2,3	2,3	NUM
eurjchem-1058	21	25	]	]	PUNCT
eurjchem-1058	21	26	.	.	PUNCT
eurjchem-1058	22	1	pioglitazone	pioglitazone	NOUN
eurjchem-1058	22	2	hydrochloride	hydrochloride	NOUN
eurjchem-1058	22	3	undergoes	undergo	VERB
eurjchem-1058	22	4	extensive	extensive	ADJ
eurjchem-1058	22	5	hepatic	hepatic	ADJ
eurjchem-1058	22	6	metabolism	metabolism	NOUN
eurjchem-1058	22	7	,	,	PUNCT
eurjchem-1058	22	8	predominantly	predominantly	ADV
eurjchem-1058	22	9	via	via	ADP
eurjchem-1058	22	10	cytochrome	cytochrome	ADJ
eurjchem-1058	22	11	p450	p450	PROPN
eurjchem-1058	22	12	(	(	PUNCT
eurjchem-1058	22	13	cyp	cyp	ADJ
eurjchem-1058	22	14	)	)	PUNCT
eurjchem-1058	22	15	2c8	2c8	NUM
eurjchem-1058	22	16	system	system	NOUN
eurjchem-1058	22	17	.	.	PUNCT
eurjchem-1058	23	1	its	its	PRON
eurjchem-1058	23	2	elimination	elimination	NOUN
eurjchem-1058	23	3	half‐life	half‐life	NOUN
eurjchem-1058	23	4	was	be	AUX
eurjchem-1058	23	5	3‐7	3‐7	NUM
eurjchem-1058	23	6	h.	h.	NOUN
eurjchem-1058	23	7	pioglitazone	pioglitazone	NOUN
eurjchem-1058	23	8	and	and	CCONJ
eurjchem-1058	23	9	its	its	PRON
eurjchem-1058	23	10	metabolites	metabolite	NOUN
eurjchem-1058	23	11	were	be	AUX
eurjchem-1058	23	12	excreted	excrete	VERB
eurjchem-1058	23	13	via	via	ADP
eurjchem-1058	23	14	urine	urine	NOUN
eurjchem-1058	23	15	(	(	PUNCT
eurjchem-1058	23	16	15‐30	15‐30	NUM
eurjchem-1058	23	17	%	%	NOUN
eurjchem-1058	23	18	)	)	PUNCT
eurjchem-1058	23	19	.	.	PUNCT
eurjchem-1058	24	1	the	the	DET
eurjchem-1058	24	2	remainders	remainder	NOUN
eurjchem-1058	24	3	were	be	AUX
eurjchem-1058	24	4	excreted	excrete	VERB
eurjchem-1058	24	5	into	into	ADP
eurjchem-1058	24	6	bile	bile	NOUN
eurjchem-1058	24	7	and	and	CCONJ
eurjchem-1058	24	8	feces	fece	NOUN
eurjchem-1058	24	9	[	[	X
eurjchem-1058	24	10	4‐6	4‐6	NOUN
eurjchem-1058	24	11	]	]	X
eurjchem-1058	24	12	.	.	PUNCT
eurjchem-1058	25	1	more	more	ADV
eurjchem-1058	25	2	recently	recently	ADV
eurjchem-1058	25	3	,	,	PUNCT
eurjchem-1058	25	4	pioglitazone	pioglitazone	NOUN
eurjchem-1058	25	5	and	and	CCONJ
eurjchem-1058	25	6	other	other	ADJ
eurjchem-1058	25	7	active	active	ADJ
eurjchem-1058	25	8	thiazolidinedione	thiazolidinedione	NOUN
eurjchem-1058	25	9	have	have	AUX
eurjchem-1058	25	10	been	be	AUX
eurjchem-1058	25	11	shown	show	VERB
eurjchem-1058	25	12	to	to	PART
eurjchem-1058	25	13	bind	bind	VERB
eurjchem-1058	25	14	to	to	ADP
eurjchem-1058	25	15	the	the	DET
eurjchem-1058	25	16	outer	outer	ADJ
eurjchem-1058	25	17	mitochondrial	mitochondrial	ADJ
eurjchem-1058	25	18	membrane	membrane	NOUN
eurjchem-1058	25	19	protein	protein	NOUN
eurjchem-1058	25	20	mitoneet	mitoneet	NOUN
eurjchem-1058	25	21	with	with	ADP
eurjchem-1058	25	22	affinity	affinity	NOUN
eurjchem-1058	25	23	comparable	comparable	ADJ
eurjchem-1058	25	24	to	to	ADP
eurjchem-1058	25	25	that	that	PRON
eurjchem-1058	25	26	of	of	ADP
eurjchem-1058	25	27	pioglitazone	pioglitazone	NOUN
eurjchem-1058	25	28	for	for	ADP
eurjchem-1058	25	29	pparγ	pparγ	NOUN
eurjchem-1058	25	30	[	[	X
eurjchem-1058	25	31	7‐10	7‐10	X
eurjchem-1058	25	32	]	]	PUNCT
eurjchem-1058	25	33	.	.	PUNCT
eurjchem-1058	26	1	pioglitazone	pioglitazone	NOUN
eurjchem-1058	26	2	hydrochloride	hydrochloride	NOUN
eurjchem-1058	26	3	reduces	reduce	VERB
eurjchem-1058	26	4	insulin	insulin	NOUN
eurjchem-1058	26	5	resistance	resistance	NOUN
eurjchem-1058	26	6	in	in	ADP
eurjchem-1058	26	7	the	the	DET
eurjchem-1058	26	8	liver	liver	NOUN
eurjchem-1058	26	9	and	and	CCONJ
eurjchem-1058	26	10	peripheral	peripheral	ADJ
eurjchem-1058	26	11	tissues	tissue	NOUN
eurjchem-1058	26	12	;	;	PUNCT
eurjchem-1058	26	13	increases	increase	VERB
eurjchem-1058	26	14	the	the	DET
eurjchem-1058	26	15	expense	expense	NOUN
eurjchem-1058	26	16	of	of	ADP
eurjchem-1058	26	17	insulin‐dependent	insulin‐dependent	ADJ
eurjchem-1058	26	18	glucose	glucose	NOUN
eurjchem-1058	26	19	;	;	PUNCT
eurjchem-1058	26	20	decreases	decrease	VERB
eurjchem-1058	26	21	withdrawal	withdrawal	NOUN
eurjchem-1058	26	22	of	of	ADP
eurjchem-1058	26	23	glucose	glucose	NOUN
eurjchem-1058	26	24	from	from	ADP
eurjchem-1058	26	25	the	the	DET
eurjchem-1058	26	26	liver	liver	NOUN
eurjchem-1058	26	27	;	;	PUNCT
eurjchem-1058	26	28	reduces	reduce	VERB
eurjchem-1058	26	29	quantity	quantity	NOUN
eurjchem-1058	26	30	of	of	ADP
eurjchem-1058	26	31	glucose	glucose	NOUN
eurjchem-1058	26	32	,	,	PUNCT
eurjchem-1058	26	33	insulin	insulin	NOUN
eurjchem-1058	26	34	and	and	CCONJ
eurjchem-1058	26	35	glycated	glycate	VERB
eurjchem-1058	26	36	haemoglobin	haemoglobin	NOUN
eurjchem-1058	26	37	in	in	ADP
eurjchem-1058	26	38	the	the	DET
eurjchem-1058	26	39	bloodstream	bloodstream	NOUN
eurjchem-1058	26	40	.	.	PUNCT
eurjchem-1058	27	1	literature	literature	NOUN
eurjchem-1058	27	2	survey	survey	NOUN
eurjchem-1058	27	3	revealed	reveal	VERB
eurjchem-1058	27	4	that	that	SCONJ
eurjchem-1058	27	5	only	only	ADV
eurjchem-1058	27	6	few	few	ADJ
eurjchem-1058	27	7	analytical	analytical	ADJ
eurjchem-1058	27	8	methods	method	NOUN
eurjchem-1058	27	9	have	have	AUX
eurjchem-1058	27	10	been	be	AUX
eurjchem-1058	27	11	reported	report	VERB
eurjchem-1058	27	12	for	for	ADP
eurjchem-1058	27	13	determining	determine	VERB
eurjchem-1058	27	14	pioglitazone	pioglitazone	NOUN
eurjchem-1058	27	15	hydrochloride	hydrochloride	NOUN
eurjchem-1058	27	16	in	in	ADP
eurjchem-1058	27	17	dosage	dosage	NOUN
eurjchem-1058	27	18	forms	form	NOUN
eurjchem-1058	27	19	as	as	ADV
eurjchem-1058	27	20	well	well	ADV
eurjchem-1058	27	21	as	as	ADP
eurjchem-1058	27	22	biological	biological	ADJ
eurjchem-1058	27	23	fluids	fluid	NOUN
eurjchem-1058	27	24	.	.	PUNCT
eurjchem-1058	28	1	zhong	zhong	PROPN
eurjchem-1058	28	2	and	and	CCONJ
eurjchem-1058	28	3	williams	williams	PROPN
eurjchem-1058	28	4	reported	report	VERB
eurjchem-1058	28	5	an	an	DET
eurjchem-1058	28	6	analytical	analytical	ADJ
eurjchem-1058	28	7	method	method	NOUN
eurjchem-1058	28	8	for	for	ADP
eurjchem-1058	28	9	the	the	DET
eurjchem-1058	28	10	simultaneous	simultaneous	ADJ
eurjchem-1058	28	11	quantitation	quantitation	NOUN
eurjchem-1058	28	12	of	of	ADP
eurjchem-1058	28	13	pioglitazone	pioglitazone	NOUN
eurjchem-1058	28	14	and	and	CCONJ
eurjchem-1058	28	15	its	its	PRON
eurjchem-1058	28	16	metabolites	metabolite	NOUN
eurjchem-1058	28	17	in	in	ADP
eurjchem-1058	28	18	human	human	ADJ
eurjchem-1058	28	19	serum	serum	NOUN
eurjchem-1058	28	20	using	use	VERB
eurjchem-1058	28	21	hplc	hplc	NOUN
eurjchem-1058	28	22	/	/	SYM
eurjchem-1058	28	23	uv	uv	NOUN
eurjchem-1058	29	1	[	[	X
eurjchem-1058	29	2	11	11	NUM
eurjchem-1058	29	3	]	]	PUNCT
eurjchem-1058	29	4	.	.	PUNCT
eurjchem-1058	30	1	yamashita	yamashita	PROPN
eurjchem-1058	30	2	et	et	PROPN
eurjchem-1058	30	3	al	al	PROPN
eurjchem-1058	30	4	.	.	PROPN
eurjchem-1058	30	5	have	have	AUX
eurjchem-1058	30	6	developed	develop	VERB
eurjchem-1058	30	7	a	a	DET
eurjchem-1058	30	8	hplc	hplc	NOUN
eurjchem-1058	30	9	method	method	NOUN
eurjchem-1058	30	10	for	for	ADP
eurjchem-1058	30	11	determination	determination	NOUN
eurjchem-1058	30	12	of	of	ADP
eurjchem-1058	30	13	pioglitazone	pioglitazone	NOUN
eurjchem-1058	30	14	and	and	CCONJ
eurjchem-1058	30	15	its	its	PRON
eurjchem-1058	30	16	metabolites	metabolite	NOUN
eurjchem-1058	30	17	in	in	ADP
eurjchem-1058	30	18	human	human	ADJ
eurjchem-1058	30	19	serum	serum	NOUN
eurjchem-1058	30	20	and	and	CCONJ
eurjchem-1058	30	21	urine	urine	NOUN
eurjchem-1058	30	22	.	.	PUNCT
eurjchem-1058	31	1	in	in	ADP
eurjchem-1058	31	2	this	this	DET
eurjchem-1058	31	3	method	method	NOUN
eurjchem-1058	31	4	separation	separation	NOUN
eurjchem-1058	31	5	was	be	AUX
eurjchem-1058	31	6	achieved	achieve	VERB
eurjchem-1058	31	7	by	by	ADP
eurjchem-1058	31	8	inertsil	inertsil	PROPN
eurjchem-1058	31	9	ods‐2	ods‐2	PROPN
eurjchem-1058	31	10	column	column	NOUN
eurjchem-1058	31	11	(	(	PUNCT
eurjchem-1058	31	12	150	150	NUM
eurjchem-1058	31	13	×	×	NOUN
eurjchem-1058	31	14	4.6	4.6	NUM
eurjchem-1058	31	15	mm	mm	NOUN
eurjchem-1058	31	16	)	)	PUNCT
eurjchem-1058	31	17	with	with	ADP
eurjchem-1058	31	18	5	5	NUM
eurjchem-1058	31	19	µm	µm	ADP
eurjchem-1058	31	20	particle	particle	NOUN
eurjchem-1058	31	21	size	size	NOUN
eurjchem-1058	31	22	,	,	PUNCT
eurjchem-1058	31	23	mobile	mobile	ADJ
eurjchem-1058	31	24	phase	phase	NOUN
eurjchem-1058	31	25	consists	consist	VERB
eurjchem-1058	31	26	of	of	ADP
eurjchem-1058	31	27	phosphate	phosphate	ADJ
eurjchem-1058	31	28	buffer	buffer	NOUN
eurjchem-1058	31	29	,	,	PUNCT
eurjchem-1058	31	30	methanol	methanol	NOUN
eurjchem-1058	31	31	and	and	CCONJ
eurjchem-1058	31	32	acetonitrile	acetonitrile	NOUN
eurjchem-1058	31	33	;	;	PUNCT
eurjchem-1058	31	34	gradient	gradient	ADJ
eurjchem-1058	31	35	elution	elution	NOUN
eurjchem-1058	31	36	was	be	AUX
eurjchem-1058	31	37	performed	perform	VERB
eurjchem-1058	31	38	at	at	ADP
eurjchem-1058	31	39	a	a	DET
eurjchem-1058	31	40	wavelength	wavelength	NOUN
eurjchem-1058	31	41	269	269	NUM
eurjchem-1058	31	42	nm	nm	NOUN
eurjchem-1058	31	43	[	[	X
eurjchem-1058	31	44	12	12	NUM
eurjchem-1058	31	45	]	]	PUNCT
eurjchem-1058	31	46	.	.	PUNCT
eurjchem-1058	32	1	radhakrishna	radhakrishna	ADV
eurjchem-1058	32	2	et	et	PROPN
eurjchem-1058	32	3	al	al	PROPN
eurjchem-1058	32	4	.	.	PROPN
eurjchem-1058	32	5	reported	report	VERB
eurjchem-1058	32	6	determination	determination	NOUN
eurjchem-1058	32	7	of	of	ADP
eurjchem-1058	32	8	pioglitazone	pioglitazone	NOUN
eurjchem-1058	32	9	hydrochloride	hydrochloride	NOUN
eurjchem-1058	32	10	in	in	ADP
eurjchem-1058	32	11	bulk	bulk	ADJ
eurjchem-1058	32	12	and	and	CCONJ
eurjchem-1058	32	13	pharmaceutical	pharmaceutical	NOUN
eurjchem-1058	32	14	formulations	formulation	NOUN
eurjchem-1058	32	15	by	by	ADP
eurjchem-1058	32	16	hplc	hplc	NOUN
eurjchem-1058	32	17	and	and	CCONJ
eurjchem-1058	32	18	mekc	mekc	NOUN
eurjchem-1058	32	19	470	470	NUM
eurjchem-1058	32	20	prava	prava	NOUN
eurjchem-1058	32	21	and	and	CCONJ
eurjchem-1058	32	22	seru	seru	PROPN
eurjchem-1058	32	23	/	/	SYM
eurjchem-1058	32	24	european	european	PROPN
eurjchem-1058	32	25	journal	journal	PROPN
eurjchem-1058	32	26	of	of	ADP
eurjchem-1058	32	27	chemistry	chemistry	NOUN
eurjchem-1058	32	28	5	5	NUM
eurjchem-1058	32	29	(	(	PUNCT
eurjchem-1058	32	30	3	3	NUM
eurjchem-1058	32	31	)	)	PUNCT
eurjchem-1058	32	32	(	(	PUNCT
eurjchem-1058	32	33	2014	2014	NUM
eurjchem-1058	32	34	)	)	PUNCT
eurjchem-1058	33	1	469‐474	469‐474	PROPN
eurjchem-1058	33	2	methods	method	NOUN
eurjchem-1058	33	3	using	use	VERB
eurjchem-1058	33	4	c18	c18	NOUN
eurjchem-1058	33	5	column	column	NOUN
eurjchem-1058	33	6	(	(	PUNCT
eurjchem-1058	33	7	250	250	NUM
eurjchem-1058	33	8	×	×	NOUN
eurjchem-1058	33	9	4.6	4.6	NUM
eurjchem-1058	33	10	mm	mm	NOUN
eurjchem-1058	33	11	)	)	PUNCT
eurjchem-1058	33	12	5	5	NUM
eurjchem-1058	33	13	µm	µm	ADP
eurjchem-1058	33	14	particle	particle	NOUN
eurjchem-1058	33	15	size	size	NOUN
eurjchem-1058	33	16	with	with	ADP
eurjchem-1058	33	17	a	a	DET
eurjchem-1058	33	18	mobile	mobile	ADJ
eurjchem-1058	33	19	phase	phase	NOUN
eurjchem-1058	33	20	consists	consist	VERB
eurjchem-1058	33	21	of	of	ADP
eurjchem-1058	33	22	phosphate	phosphate	ADJ
eurjchem-1058	33	23	buffer	buffer	NOUN
eurjchem-1058	33	24	and	and	CCONJ
eurjchem-1058	33	25	acetonitrile	acetonitrile	NOUN
eurjchem-1058	33	26	,	,	PUNCT
eurjchem-1058	33	27	detection	detection	NOUN
eurjchem-1058	33	28	was	be	AUX
eurjchem-1058	33	29	carried	carry	VERB
eurjchem-1058	33	30	out	out	ADP
eurjchem-1058	33	31	by	by	ADP
eurjchem-1058	33	32	225	225	NUM
eurjchem-1058	33	33	nm	nm	NOUN
eurjchem-1058	34	1	[	[	X
eurjchem-1058	34	2	13	13	NUM
eurjchem-1058	34	3	]	]	PUNCT
eurjchem-1058	34	4	.	.	PUNCT
eurjchem-1058	35	1	xue	xue	PROPN
eurjchem-1058	35	2	et	et	PROPN
eurjchem-1058	35	3	al	al	PROPN
eurjchem-1058	35	4	.	.	PROPN
eurjchem-1058	35	5	have	have	AUX
eurjchem-1058	35	6	studied	study	VERB
eurjchem-1058	35	7	a	a	DET
eurjchem-1058	35	8	quantitative	quantitative	ADJ
eurjchem-1058	35	9	determination	determination	NOUN
eurjchem-1058	35	10	of	of	ADP
eurjchem-1058	35	11	pioglitazone	pioglitazone	NOUN
eurjchem-1058	35	12	in	in	ADP
eurjchem-1058	35	13	human	human	ADJ
eurjchem-1058	35	14	serum	serum	NOUN
eurjchem-1058	35	15	by	by	ADP
eurjchem-1058	35	16	direct‐injection	direct‐injection	NOUN
eurjchem-1058	35	17	hplc	hplc	PROPN
eurjchem-1058	35	18	/	/	SYM
eurjchem-1058	35	19	ms	ms	PROPN
eurjchem-1058	35	20	and	and	CCONJ
eurjchem-1058	35	21	its	its	PRON
eurjchem-1058	35	22	application	application	NOUN
eurjchem-1058	35	23	to	to	ADP
eurjchem-1058	35	24	bioequivalence	bioequivalence	NOUN
eurjchem-1058	35	25	study	study	NOUN
eurjchem-1058	35	26	[	[	X
eurjchem-1058	35	27	14	14	NUM
eurjchem-1058	35	28	]	]	PUNCT
eurjchem-1058	35	29	.	.	PUNCT
eurjchem-1058	36	1	sane	sane	INTJ
eurjchem-1058	36	2	et	et	PROPN
eurjchem-1058	36	3	al	al	PROPN
eurjchem-1058	36	4	.	.	PROPN
eurjchem-1058	36	5	have	have	AUX
eurjchem-1058	36	6	developed	develop	VERB
eurjchem-1058	36	7	a	a	DET
eurjchem-1058	36	8	hplc	hplc	NOUN
eurjchem-1058	36	9	method	method	NOUN
eurjchem-1058	36	10	for	for	ADP
eurjchem-1058	36	11	simultaneous	simultaneous	ADJ
eurjchem-1058	36	12	determination	determination	NOUN
eurjchem-1058	36	13	of	of	ADP
eurjchem-1058	36	14	pioglitazone	pioglitazone	NOUN
eurjchem-1058	36	15	and	and	CCONJ
eurjchem-1058	36	16	glimipride	glimipride	NOUN
eurjchem-1058	37	1	[	[	X
eurjchem-1058	37	2	15	15	NUM
eurjchem-1058	37	3	]	]	PUNCT
eurjchem-1058	37	4	.	.	PUNCT
eurjchem-1058	38	1	sripalakit	sripalakit	PROPN
eurjchem-1058	38	2	et	et	PROPN
eurjchem-1058	38	3	al	al	PROPN
eurjchem-1058	38	4	.	.	PROPN
eurjchem-1058	38	5	have	have	AUX
eurjchem-1058	38	6	reported	report	VERB
eurjchem-1058	38	7	a	a	DET
eurjchem-1058	38	8	hplc	hplc	NOUN
eurjchem-1058	38	9	method	method	NOUN
eurjchem-1058	38	10	for	for	ADP
eurjchem-1058	38	11	the	the	DET
eurjchem-1058	38	12	determination	determination	NOUN
eurjchem-1058	38	13	of	of	ADP
eurjchem-1058	38	14	pioglitazone	pioglitazone	NOUN
eurjchem-1058	38	15	in	in	ADP
eurjchem-1058	38	16	human	human	ADJ
eurjchem-1058	38	17	plasma	plasma	NOUN
eurjchem-1058	38	18	using	use	VERB
eurjchem-1058	38	19	uv	uv	NOUN
eurjchem-1058	38	20	detection	detection	NOUN
eurjchem-1058	38	21	and	and	CCONJ
eurjchem-1058	38	22	its	its	PRON
eurjchem-1058	38	23	application	application	NOUN
eurjchem-1058	38	24	to	to	ADP
eurjchem-1058	38	25	a	a	DET
eurjchem-1058	38	26	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-1058	38	27	study	study	NOUN
eurjchem-1058	38	28	.	.	PUNCT
eurjchem-1058	39	1	in	in	ADP
eurjchem-1058	39	2	this	this	DET
eurjchem-1058	39	3	method	method	NOUN
eurjchem-1058	39	4	chromatographic	chromatographic	ADJ
eurjchem-1058	39	5	separation	separation	NOUN
eurjchem-1058	39	6	was	be	AUX
eurjchem-1058	39	7	achieved	achieve	VERB
eurjchem-1058	39	8	with	with	ADP
eurjchem-1058	39	9	a	a	DET
eurjchem-1058	39	10	rp	rp	NOUN
eurjchem-1058	39	11	apollo	apollo	PROPN
eurjchem-1058	39	12	c18	c18	PROPN
eurjchem-1058	39	13	column	column	NOUN
eurjchem-1058	39	14	and	and	CCONJ
eurjchem-1058	39	15	mobile	mobile	ADJ
eurjchem-1058	39	16	phase	phase	NOUN
eurjchem-1058	39	17	consisting	consist	VERB
eurjchem-1058	39	18	of	of	ADP
eurjchem-1058	39	19	methanol	methanol	NOUN
eurjchem-1058	39	20	,	,	PUNCT
eurjchem-1058	39	21	acetonitrile	acetonitrile	NOUN
eurjchem-1058	39	22	,	,	PUNCT
eurjchem-1058	39	23	phosphate	phosphate	ADJ
eurjchem-1058	39	24	buffer	buffer	NOUN
eurjchem-1058	39	25	,	,	PUNCT
eurjchem-1058	39	26	at	at	ADP
eurjchem-1058	39	27	a	a	DET
eurjchem-1058	39	28	wavelength	wavelength	NOUN
eurjchem-1058	39	29	269	269	NUM
eurjchem-1058	39	30	nm	nm	NOUN
eurjchem-1058	40	1	[	[	X
eurjchem-1058	40	2	16	16	NUM
eurjchem-1058	40	3	]	]	PUNCT
eurjchem-1058	40	4	.	.	PUNCT
eurjchem-1058	41	1	lofty	lofty	ADJ
eurjchem-1058	41	2	saber	saber	NOUN
eurjchem-1058	41	3	reported	report	VERB
eurjchem-1058	41	4	a	a	DET
eurjchem-1058	41	5	hplc	hplc	NOUN
eurjchem-1058	41	6	method	method	NOUN
eurjchem-1058	41	7	for	for	ADP
eurjchem-1058	41	8	determina‐	determina‐	NOUN
eurjchem-1058	41	9	tion	tion	NOUN
eurjchem-1058	41	10	of	of	ADP
eurjchem-1058	41	11	pioglitazone	pioglitazone	NOUN
eurjchem-1058	41	12	hydrochloride	hydrochloride	NOUN
eurjchem-1058	41	13	in	in	ADP
eurjchem-1058	41	14	tablets	tablet	NOUN
eurjchem-1058	41	15	[	[	X
eurjchem-1058	41	16	17	17	NUM
eurjchem-1058	41	17	]	]	PUNCT
eurjchem-1058	41	18	.	.	PUNCT
eurjchem-1058	42	1	tahmasebi	tahmasebi	AUX
eurjchem-1058	42	2	et	et	PROPN
eurjchem-1058	42	3	al	al	PROPN
eurjchem-1058	42	4	.	.	PROPN
eurjchem-1058	42	5	have	have	AUX
eurjchem-1058	42	6	studied	study	VERB
eurjchem-1058	42	7	an	an	DET
eurjchem-1058	42	8	extraction	extraction	NOUN
eurjchem-1058	42	9	of	of	ADP
eurjchem-1058	42	10	trace	trace	NOUN
eurjchem-1058	42	11	amounts	amount	NOUN
eurjchem-1058	42	12	of	of	ADP
eurjchem-1058	42	13	pioglitazone	pioglitazone	NOUN
eurjchem-1058	42	14	with	with	ADP
eurjchem-1058	42	15	hollow	hollow	ADJ
eurjchem-1058	42	16	fiber	fiber	NOUN
eurjchem-1058	42	17	liquid	liquid	NOUN
eurjchem-1058	42	18	phase	phase	NOUN
eurjchem-1058	42	19	micro	micro	NOUN
eurjchem-1058	42	20	extraction	extraction	NOUN
eurjchem-1058	42	21	by	by	ADP
eurjchem-1058	42	22	hplc‐uv	hplc‐uv	PROPN
eurjchem-1058	42	23	detection	detection	NOUN
eurjchem-1058	42	24	in	in	ADP
eurjchem-1058	42	25	biological	biological	ADJ
eurjchem-1058	42	26	fluids	fluid	NOUN
eurjchem-1058	42	27	[	[	X
eurjchem-1058	42	28	18,19	18,19	NUM
eurjchem-1058	42	29	]	]	X
eurjchem-1058	42	30	.	.	PUNCT
eurjchem-1058	43	1	although	although	SCONJ
eurjchem-1058	43	2	,	,	PUNCT
eurjchem-1058	43	3	to	to	ADP
eurjchem-1058	43	4	date	date	NOUN
eurjchem-1058	43	5	there	there	PRON
eurjchem-1058	43	6	is	be	VERB
eurjchem-1058	43	7	no	no	DET
eurjchem-1058	43	8	method	method	NOUN
eurjchem-1058	43	9	reported	report	VERB
eurjchem-1058	43	10	for	for	ADP
eurjchem-1058	43	11	determination	determination	NOUN
eurjchem-1058	43	12	of	of	ADP
eurjchem-1058	43	13	process‐related	process‐related	ADJ
eurjchem-1058	43	14	substances	substance	NOUN
eurjchem-1058	43	15	of	of	ADP
eurjchem-1058	43	16	pioglitazone	pioglitazone	NOUN
eurjchem-1058	43	17	hydrochloride	hydrochloride	NOUN
eurjchem-1058	43	18	in	in	ADP
eurjchem-1058	43	19	the	the	DET
eurjchem-1058	43	20	literature	literature	NOUN
eurjchem-1058	43	21	(	(	PUNCT
eurjchem-1058	43	22	figure	figure	NOUN
eurjchem-1058	43	23	1	1	NUM
eurjchem-1058	43	24	)	)	PUNCT
eurjchem-1058	43	25	.	.	PUNCT
eurjchem-1058	44	1	the	the	DET
eurjchem-1058	44	2	present	present	ADJ
eurjchem-1058	44	3	study	study	NOUN
eurjchem-1058	44	4	is	be	AUX
eurjchem-1058	44	5	aimed	aim	VERB
eurjchem-1058	44	6	at	at	ADP
eurjchem-1058	44	7	separation	separation	NOUN
eurjchem-1058	44	8	and	and	CCONJ
eurjchem-1058	44	9	determination	determination	NOUN
eurjchem-1058	44	10	of	of	ADP
eurjchem-1058	44	11	pioglitazone	pioglitazone	NOUN
eurjchem-1058	44	12	hydrochloride	hydrochloride	NOUN
eurjchem-1058	44	13	and	and	CCONJ
eurjchem-1058	44	14	its	its	PRON
eurjchem-1058	44	15	process‐	process‐	NOUN
eurjchem-1058	44	16	related	relate	VERB
eurjchem-1058	44	17	impurities	impurity	NOUN
eurjchem-1058	44	18	by	by	ADP
eurjchem-1058	44	19	rp‐hplc	rp‐hplc	PROPN
eurjchem-1058	44	20	method	method	NOUN
eurjchem-1058	44	21	[	[	X
eurjchem-1058	44	22	19‐21	19‐21	NUM
eurjchem-1058	44	23	]	]	PUNCT
eurjchem-1058	44	24	.	.	PUNCT
eurjchem-1058	45	1	figure	figure	NOUN
eurjchem-1058	45	2	1	1	NUM
eurjchem-1058	45	3	.	.	PUNCT
eurjchem-1058	46	1	chemical	chemical	NOUN
eurjchem-1058	46	2	structures	structure	NOUN
eurjchem-1058	46	3	of	of	ADP
eurjchem-1058	46	4	the	the	DET
eurjchem-1058	46	5	pioglitazone	pioglitazone	NOUN
eurjchem-1058	46	6	hydrochloride	hydrochloride	NOUN
eurjchem-1058	46	7	and	and	CCONJ
eurjchem-1058	46	8	impurities	impurity	NOUN
eurjchem-1058	46	9	a‐c	a‐c	PROPN
eurjchem-1058	46	10	.	.	PROPN
eurjchem-1058	47	1	2	2	NUM
eurjchem-1058	47	2	.	.	X
eurjchem-1058	47	3	experimental	experimental	ADJ
eurjchem-1058	47	4	2.1	2.1	NUM
eurjchem-1058	47	5	.	.	PUNCT
eurjchem-1058	47	6	instrumentation	instrumentation	NOUN
eurjchem-1058	47	7	an	an	DET
eurjchem-1058	47	8	integrated	integrate	VERB
eurjchem-1058	47	9	hplc	hplc	NOUN
eurjchem-1058	47	10	system	system	NOUN
eurjchem-1058	47	11	with	with	ADP
eurjchem-1058	47	12	computer	computer	NOUN
eurjchem-1058	47	13	based	base	VERB
eurjchem-1058	47	14	chromatography	chromatography	NOUN
eurjchem-1058	47	15	software	software	NOUN
eurjchem-1058	47	16	(	(	PUNCT
eurjchem-1058	47	17	empower	empower	NOUN
eurjchem-1058	47	18	)	)	PUNCT
eurjchem-1058	47	19	was	be	AUX
eurjchem-1058	47	20	used	use	VERB
eurjchem-1058	47	21	.	.	PUNCT
eurjchem-1058	48	1	the	the	DET
eurjchem-1058	48	2	water	water	NOUN
eurjchem-1058	48	3	’s	’s	PART
eurjchem-1058	48	4	alliance	alliance	NOUN
eurjchem-1058	48	5	system	system	NOUN
eurjchem-1058	48	6	with	with	ADP
eurjchem-1058	48	7	2695	2695	NUM
eurjchem-1058	48	8	quaternary	quaternary	ADJ
eurjchem-1058	48	9	low	low	ADJ
eurjchem-1058	48	10	pressure	pressure	NOUN
eurjchem-1058	48	11	gradient	gradient	NOUN
eurjchem-1058	48	12	system	system	NOUN
eurjchem-1058	48	13	,	,	PUNCT
eurjchem-1058	48	14	auto	auto	NOUN
eurjchem-1058	48	15	sampler	sampler	NOUN
eurjchem-1058	48	16	,	,	PUNCT
eurjchem-1058	48	17	column	column	NOUN
eurjchem-1058	48	18	thermostat	thermostat	NOUN
eurjchem-1058	48	19	and	and	CCONJ
eurjchem-1058	48	20	photodiode	photodiode	NOUN
eurjchem-1058	48	21	array	array	NOUN
eurjchem-1058	48	22	detector	detector	NOUN
eurjchem-1058	48	23	was	be	AUX
eurjchem-1058	48	24	used	use	VERB
eurjchem-1058	48	25	for	for	ADP
eurjchem-1058	48	26	this	this	DET
eurjchem-1058	48	27	experiment	experiment	NOUN
eurjchem-1058	48	28	.	.	PUNCT
eurjchem-1058	49	1	2.2	2.2	NUM
eurjchem-1058	49	2	.	.	PUNCT
eurjchem-1058	49	3	chemicals	chemical	NOUN
eurjchem-1058	49	4	and	and	CCONJ
eurjchem-1058	49	5	reagents	reagent	NOUN
eurjchem-1058	49	6	pioglitazone	pioglitazone	NOUN
eurjchem-1058	49	7	hydrochloride	hydrochloride	NOUN
eurjchem-1058	49	8	working	work	VERB
eurjchem-1058	49	9	standard	standard	NOUN
eurjchem-1058	49	10	and	and	CCONJ
eurjchem-1058	49	11	its	its	PRON
eurjchem-1058	49	12	process	process	NOUN
eurjchem-1058	49	13	related	relate	VERB
eurjchem-1058	49	14	impurities	impurity	NOUN
eurjchem-1058	49	15	were	be	AUX
eurjchem-1058	49	16	synthesized	synthesize	VERB
eurjchem-1058	49	17	at	at	ADP
eurjchem-1058	49	18	pharmazell	pharmazell	ADJ
eurjchem-1058	49	19	research	research	NOUN
eurjchem-1058	49	20	centre	centre	NOUN
eurjchem-1058	49	21	,	,	PUNCT
eurjchem-1058	49	22	visakhapatnam	visakhapatnam	PROPN
eurjchem-1058	49	23	(	(	PUNCT
eurjchem-1058	49	24	india	india	PROPN
eurjchem-1058	49	25	)	)	PUNCT
eurjchem-1058	49	26	and	and	CCONJ
eurjchem-1058	49	27	obtained	obtain	VERB
eurjchem-1058	49	28	as	as	ADP
eurjchem-1058	49	29	gift	gift	NOUN
eurjchem-1058	49	30	samples	sample	NOUN
eurjchem-1058	49	31	.	.	PUNCT
eurjchem-1058	50	1	hplc	hplc	NOUN
eurjchem-1058	50	2	grade	grade	NOUN
eurjchem-1058	50	3	acetonitrile	acetonitrile	NOUN
eurjchem-1058	50	4	was	be	AUX
eurjchem-1058	50	5	obtained	obtain	VERB
eurjchem-1058	50	6	from	from	ADP
eurjchem-1058	50	7	merck	merck	PROPN
eurjchem-1058	50	8	.	.	PROPN
eurjchem-1058	51	1	analytical	analytical	ADJ
eurjchem-1058	51	2	grade	grade	NOUN
eurjchem-1058	51	3	ammonium	ammonium	NOUN
eurjchem-1058	51	4	acetate	acetate	NOUN
eurjchem-1058	51	5	,	,	PUNCT
eurjchem-1058	51	6	acetic	acetic	ADJ
eurjchem-1058	51	7	acid	acid	NOUN
eurjchem-1058	51	8	was	be	AUX
eurjchem-1058	51	9	used	use	VERB
eurjchem-1058	51	10	.	.	PUNCT
eurjchem-1058	52	1	high	high	ADJ
eurjchem-1058	52	2	purity	purity	NOUN
eurjchem-1058	52	3	water	water	NOUN
eurjchem-1058	52	4	was	be	AUX
eurjchem-1058	52	5	prepared	prepare	VERB
eurjchem-1058	52	6	by	by	ADP
eurjchem-1058	52	7	using	use	VERB
eurjchem-1058	52	8	milli‐q	milli‐q	PROPN
eurjchem-1058	52	9	elix	elix	PROPN
eurjchem-1058	52	10	and	and	CCONJ
eurjchem-1058	52	11	then	then	ADV
eurjchem-1058	52	12	using	use	VERB
eurjchem-1058	52	13	milli‐q	milli‐q	PROPN
eurjchem-1058	52	14	academic	academic	ADJ
eurjchem-1058	52	15	purification	purification	NOUN
eurjchem-1058	52	16	system	system	NOUN
eurjchem-1058	52	17	(	(	PUNCT
eurjchem-1058	52	18	millipore	millipore	NOUN
eurjchem-1058	52	19	)	)	PUNCT
eurjchem-1058	52	20	.	.	PUNCT
eurjchem-1058	53	1	5‐(4‐(2‐(5‐	5‐(4‐(2‐(5‐	NUM
eurjchem-1058	53	2	ethylpyridin‐2‐yl)ethoxy)benzyl)‐2‐iminothiazolidin‐4‐one	ethylpyridin‐2‐yl)ethoxy)benzyl)‐2‐iminothiazolidin‐4‐one	PROPN
eurjchem-1058	53	3	was	be	AUX
eurjchem-1058	53	4	purchased	purchase	VERB
eurjchem-1058	53	5	from	from	ADP
eurjchem-1058	53	6	(	(	PUNCT
eurjchem-1058	53	7	sigma	sigma	PROPN
eurjchem-1058	53	8	)	)	PUNCT
eurjchem-1058	53	9	.	.	PUNCT
eurjchem-1058	54	1	2.3	2.3	NUM
eurjchem-1058	54	2	.	.	PUNCT
eurjchem-1058	54	3	preparation	preparation	NOUN
eurjchem-1058	54	4	of	of	ADP
eurjchem-1058	54	5	solutions	solution	NOUN
eurjchem-1058	54	6	2.3.1	2.3.1	NUM
eurjchem-1058	54	7	.	.	PUNCT
eurjchem-1058	54	8	preparation	preparation	NOUN
eurjchem-1058	54	9	of	of	ADP
eurjchem-1058	54	10	buffer	buffer	NOUN
eurjchem-1058	54	11	1.54	1.54	NUM
eurjchem-1058	54	12	g	g	NOUN
eurjchem-1058	54	13	of	of	ADP
eurjchem-1058	54	14	ammonium	ammonium	NOUN
eurjchem-1058	54	15	acetate	acetate	NOUN
eurjchem-1058	54	16	was	be	AUX
eurjchem-1058	54	17	dissolved	dissolve	VERB
eurjchem-1058	54	18	in	in	ADP
eurjchem-1058	54	19	1000	1000	NUM
eurjchem-1058	54	20	ml	ml	NOUN
eurjchem-1058	54	21	of	of	ADP
eurjchem-1058	54	22	water	water	NOUN
eurjchem-1058	54	23	,	,	PUNCT
eurjchem-1058	54	24	ph	ph	PROPN
eurjchem-1058	54	25	was	be	AUX
eurjchem-1058	54	26	adjusted	adjust	VERB
eurjchem-1058	54	27	to	to	ADP
eurjchem-1058	54	28	4.6±0.05	4.6±0.05	NUM
eurjchem-1058	54	29	with	with	ADP
eurjchem-1058	54	30	acetic	acetic	ADJ
eurjchem-1058	54	31	acid	acid	NOUN
eurjchem-1058	54	32	,	,	PUNCT
eurjchem-1058	54	33	filtered	filter	VERB
eurjchem-1058	54	34	through	through	ADP
eurjchem-1058	54	35	0.45	0.45	NUM
eurjchem-1058	54	36	µ	µ	NOUN
eurjchem-1058	54	37	size	size	NOUN
eurjchem-1058	54	38	filter	filter	NOUN
eurjchem-1058	54	39	paper	paper	NOUN
eurjchem-1058	54	40	and	and	CCONJ
eurjchem-1058	54	41	degassed	degas	VERB
eurjchem-1058	54	42	in	in	ADP
eurjchem-1058	54	43	an	an	DET
eurjchem-1058	54	44	ultrasonic	ultrasonic	ADJ
eurjchem-1058	54	45	bath	bath	NOUN
eurjchem-1058	54	46	.	.	PUNCT
eurjchem-1058	55	1	2.3.2	2.3.2	NUM
eurjchem-1058	55	2	.	.	PUNCT
eurjchem-1058	55	3	preparation	preparation	NOUN
eurjchem-1058	55	4	of	of	ADP
eurjchem-1058	55	5	mobile	mobile	ADJ
eurjchem-1058	55	6	phase	phase	NOUN
eurjchem-1058	55	7	solvent	solvent	NOUN
eurjchem-1058	55	8	a	a	PRON
eurjchem-1058	55	9	:	:	PUNCT
eurjchem-1058	55	10	a	a	DET
eurjchem-1058	55	11	mixture	mixture	NOUN
eurjchem-1058	55	12	of	of	ADP
eurjchem-1058	55	13	acetonitrile	acetonitrile	NOUN
eurjchem-1058	55	14	and	and	CCONJ
eurjchem-1058	55	15	buffer	buffer	VERB
eurjchem-1058	55	16	in	in	ADP
eurjchem-1058	55	17	the	the	DET
eurjchem-1058	55	18	ratio	ratio	NOUN
eurjchem-1058	55	19	(	(	PUNCT
eurjchem-1058	55	20	43:57	43:57	NUM
eurjchem-1058	55	21	,	,	PUNCT
eurjchem-1058	55	22	v	v	NOUN
eurjchem-1058	55	23	:	:	PUNCT
eurjchem-1058	55	24	v	v	NOUN
eurjchem-1058	55	25	)	)	PUNCT
eurjchem-1058	55	26	was	be	AUX
eurjchem-1058	55	27	prepared	prepare	VERB
eurjchem-1058	55	28	.	.	PUNCT
eurjchem-1058	56	1	solvent	solvent	PROPN
eurjchem-1058	56	2	b	b	NOUN
eurjchem-1058	56	3	:	:	PUNCT
eurjchem-1058	56	4	a	a	DET
eurjchem-1058	56	5	mixture	mixture	NOUN
eurjchem-1058	56	6	of	of	ADP
eurjchem-1058	56	7	acetonitrile	acetonitrile	NOUN
eurjchem-1058	56	8	and	and	CCONJ
eurjchem-1058	56	9	buffer	buffer	VERB
eurjchem-1058	56	10	in	in	ADP
eurjchem-1058	56	11	the	the	DET
eurjchem-1058	56	12	ratio	ratio	NOUN
eurjchem-1058	56	13	(	(	PUNCT
eurjchem-1058	56	14	80:20	80:20	NUM
eurjchem-1058	56	15	,	,	PUNCT
eurjchem-1058	56	16	v	v	NOUN
eurjchem-1058	56	17	:	:	SYM
eurjchem-1058	56	18	v	v	NOUN
eurjchem-1058	56	19	)	)	PUNCT
eurjchem-1058	56	20	was	be	AUX
eurjchem-1058	56	21	prepared	prepare	VERB
eurjchem-1058	56	22	.	.	PUNCT
eurjchem-1058	57	1	2.3.3	2.3.3	X
eurjchem-1058	57	2	.	.	PUNCT
eurjchem-1058	57	3	preparation	preparation	NOUN
eurjchem-1058	57	4	of	of	ADP
eurjchem-1058	57	5	diluent	diluent	NOUN
eurjchem-1058	57	6	a	a	DET
eurjchem-1058	57	7	mixture	mixture	NOUN
eurjchem-1058	57	8	of	of	ADP
eurjchem-1058	57	9	tetrahydrofuran	tetrahydrofuran	NOUN
eurjchem-1058	57	10	and	and	CCONJ
eurjchem-1058	57	11	methanol	methanol	NOUN
eurjchem-1058	57	12	in	in	ADP
eurjchem-1058	57	13	the	the	DET
eurjchem-1058	57	14	ratio	ratio	NOUN
eurjchem-1058	57	15	(	(	PUNCT
eurjchem-1058	57	16	1:3	1:3	NUM
eurjchem-1058	57	17	,	,	PUNCT
eurjchem-1058	57	18	v	v	NOUN
eurjchem-1058	57	19	:	:	PUNCT
eurjchem-1058	57	20	v	v	NOUN
eurjchem-1058	57	21	)	)	PUNCT
eurjchem-1058	57	22	was	be	AUX
eurjchem-1058	57	23	prepared	prepare	VERB
eurjchem-1058	57	24	.	.	PUNCT
eurjchem-1058	58	1	2.3.4	2.3.4	X
eurjchem-1058	58	2	.	.	PUNCT
eurjchem-1058	58	3	preparation	preparation	NOUN
eurjchem-1058	58	4	of	of	ADP
eurjchem-1058	58	5	standard	standard	ADJ
eurjchem-1058	58	6	solution	solution	NOUN
eurjchem-1058	58	7	standard	standard	ADJ
eurjchem-1058	58	8	solution	solution	NOUN
eurjchem-1058	58	9	was	be	AUX
eurjchem-1058	58	10	prepared	prepare	VERB
eurjchem-1058	58	11	by	by	ADP
eurjchem-1058	58	12	weighing	weigh	VERB
eurjchem-1058	58	13	accurately	accurately	ADV
eurjchem-1058	58	14	50	50	NUM
eurjchem-1058	58	15	mg	mg	NOUN
eurjchem-1058	58	16	of	of	ADP
eurjchem-1058	58	17	pioglitazone	pioglitazone	NOUN
eurjchem-1058	58	18	hydrochloride	hydrochloride	NOUN
eurjchem-1058	58	19	and	and	CCONJ
eurjchem-1058	58	20	transferred	transfer	VERB
eurjchem-1058	58	21	into	into	ADP
eurjchem-1058	58	22	50	50	NUM
eurjchem-1058	58	23	ml	ml	NOUN
eurjchem-1058	58	24	volumetric	volumetric	NOUN
eurjchem-1058	58	25	flask	flask	NOUN
eurjchem-1058	58	26	containing	contain	VERB
eurjchem-1058	58	27	30	30	NUM
eurjchem-1058	58	28	ml	ml	NOUN
eurjchem-1058	58	29	of	of	ADP
eurjchem-1058	58	30	diluent	diluent	NOUN
eurjchem-1058	58	31	.	.	PUNCT
eurjchem-1058	59	1	the	the	DET
eurjchem-1058	59	2	flask	flask	NOUN
eurjchem-1058	59	3	was	be	AUX
eurjchem-1058	59	4	then	then	ADV
eurjchem-1058	59	5	sonicated	sonicate	VERB
eurjchem-1058	59	6	for	for	ADP
eurjchem-1058	59	7	10	10	NUM
eurjchem-1058	59	8	min	min	NOUN
eurjchem-1058	59	9	to	to	PART
eurjchem-1058	59	10	dissolve	dissolve	VERB
eurjchem-1058	59	11	the	the	DET
eurjchem-1058	59	12	drug	drug	NOUN
eurjchem-1058	59	13	completely	completely	ADV
eurjchem-1058	59	14	and	and	CCONJ
eurjchem-1058	59	15	the	the	DET
eurjchem-1058	59	16	volume	volume	NOUN
eurjchem-1058	59	17	made	make	VERB
eurjchem-1058	59	18	up	up	ADP
eurjchem-1058	59	19	to	to	PART
eurjchem-1058	59	20	50	50	NUM
eurjchem-1058	59	21	ml	ml	NOUN
eurjchem-1058	59	22	with	with	ADP
eurjchem-1058	59	23	diluent	diluent	NOUN
eurjchem-1058	59	24	(	(	PUNCT
eurjchem-1058	59	25	1	1	NUM
eurjchem-1058	59	26	mg	mg	NUM
eurjchem-1058	59	27	/	/	SYM
eurjchem-1058	59	28	ml	ml	NOUN
eurjchem-1058	59	29	)	)	PUNCT
eurjchem-1058	59	30	.	.	PUNCT
eurjchem-1058	60	1	2.3.5	2.3.5	NUM
eurjchem-1058	60	2	.	.	PUNCT
eurjchem-1058	60	3	preparation	preparation	NOUN
eurjchem-1058	60	4	of	of	ADP
eurjchem-1058	60	5	test	test	NOUN
eurjchem-1058	60	6	solution	solution	NOUN
eurjchem-1058	60	7	about	about	ADP
eurjchem-1058	60	8	50	50	NUM
eurjchem-1058	60	9	mg	mg	NOUN
eurjchem-1058	60	10	of	of	ADP
eurjchem-1058	60	11	sample	sample	NOUN
eurjchem-1058	60	12	was	be	AUX
eurjchem-1058	60	13	weighed	weigh	VERB
eurjchem-1058	60	14	accurately	accurately	ADV
eurjchem-1058	60	15	and	and	CCONJ
eurjchem-1058	60	16	transferred	transfer	VERB
eurjchem-1058	60	17	into	into	ADP
eurjchem-1058	60	18	50	50	NUM
eurjchem-1058	60	19	ml	ml	NOUN
eurjchem-1058	60	20	volumetric	volumetric	ADJ
eurjchem-1058	60	21	flask	flask	NOUN
eurjchem-1058	60	22	,	,	PUNCT
eurjchem-1058	60	23	add	add	VERB
eurjchem-1058	60	24	30	30	NUM
eurjchem-1058	60	25	ml	ml	NOUN
eurjchem-1058	60	26	of	of	ADP
eurjchem-1058	60	27	diluent	diluent	NOUN
eurjchem-1058	60	28	,	,	PUNCT
eurjchem-1058	60	29	sonicated	sonicate	VERB
eurjchem-1058	60	30	for	for	ADP
eurjchem-1058	60	31	10	10	NUM
eurjchem-1058	60	32	min	min	NOUN
eurjchem-1058	60	33	to	to	PART
eurjchem-1058	60	34	dissolve	dissolve	VERB
eurjchem-1058	60	35	the	the	DET
eurjchem-1058	60	36	drug	drug	NOUN
eurjchem-1058	60	37	completely	completely	ADV
eurjchem-1058	60	38	and	and	CCONJ
eurjchem-1058	60	39	the	the	DET
eurjchem-1058	60	40	volume	volume	NOUN
eurjchem-1058	60	41	was	be	AUX
eurjchem-1058	60	42	made	make	VERB
eurjchem-1058	60	43	up	up	ADP
eurjchem-1058	60	44	to	to	ADP
eurjchem-1058	60	45	50	50	NUM
eurjchem-1058	60	46	ml	ml	NOUN
eurjchem-1058	60	47	with	with	ADP
eurjchem-1058	60	48	diluent	diluent	NOUN
eurjchem-1058	60	49	.	.	PUNCT
eurjchem-1058	61	1	2.3.6	2.3.6	NUM
eurjchem-1058	61	2	.	.	PUNCT
eurjchem-1058	61	3	preparation	preparation	NOUN
eurjchem-1058	61	4	of	of	ADP
eurjchem-1058	61	5	impurity	impurity	NOUN
eurjchem-1058	61	6	mixture	mixture	NOUN
eurjchem-1058	61	7	about	about	ADP
eurjchem-1058	61	8	38	38	NUM
eurjchem-1058	61	9	mg	mg	NOUN
eurjchem-1058	61	10	of	of	ADP
eurjchem-1058	61	11	pioglitazone	pioglitazone	NOUN
eurjchem-1058	61	12	hydrochloride	hydrochloride	NOUN
eurjchem-1058	61	13	and	and	CCONJ
eurjchem-1058	61	14	its	its	PRON
eurjchem-1058	61	15	process	process	NOUN
eurjchem-1058	61	16	related	relate	VERB
eurjchem-1058	61	17	impurities	impurity	NOUN
eurjchem-1058	61	18	(	(	PUNCT
eurjchem-1058	61	19	impurity	impurity	NOUN
eurjchem-1058	61	20	a	a	PRON
eurjchem-1058	61	21	,	,	PUNCT
eurjchem-1058	61	22	b	b	PROPN
eurjchem-1058	61	23	and	and	CCONJ
eurjchem-1058	61	24	c	c	X
eurjchem-1058	61	25	)	)	PUNCT
eurjchem-1058	61	26	were	be	AUX
eurjchem-1058	61	27	weighed	weigh	VERB
eurjchem-1058	61	28	accurately	accurately	ADV
eurjchem-1058	61	29	and	and	CCONJ
eurjchem-1058	61	30	transferred	transfer	VERB
eurjchem-1058	61	31	into	into	ADP
eurjchem-1058	61	32	100	100	NUM
eurjchem-1058	61	33	ml	ml	NOUN
eurjchem-1058	61	34	volumetric	volumetric	ADJ
eurjchem-1058	61	35	flask	flask	NOUN
eurjchem-1058	61	36	,	,	PUNCT
eurjchem-1058	61	37	60	60	NUM
eurjchem-1058	61	38	ml	ml	NOUN
eurjchem-1058	61	39	of	of	ADP
eurjchem-1058	61	40	diluent	diluent	NOUN
eurjchem-1058	61	41	was	be	AUX
eurjchem-1058	61	42	added	add	VERB
eurjchem-1058	61	43	,	,	PUNCT
eurjchem-1058	61	44	sonicated	sonicate	VERB
eurjchem-1058	61	45	for	for	ADP
eurjchem-1058	61	46	10	10	NUM
eurjchem-1058	61	47	min	min	NOUN
eurjchem-1058	61	48	to	to	PART
eurjchem-1058	61	49	dissolve	dissolve	VERB
eurjchem-1058	61	50	the	the	DET
eurjchem-1058	61	51	compounds	compound	NOUN
eurjchem-1058	61	52	and	and	CCONJ
eurjchem-1058	61	53	the	the	DET
eurjchem-1058	61	54	volume	volume	NOUN
eurjchem-1058	61	55	was	be	AUX
eurjchem-1058	61	56	made	make	VERB
eurjchem-1058	61	57	up	up	ADP
eurjchem-1058	61	58	to	to	PART
eurjchem-1058	61	59	100	100	NUM
eurjchem-1058	61	60	ml	ml	NOUN
eurjchem-1058	61	61	with	with	ADP
eurjchem-1058	61	62	diluent	diluent	NOUN
eurjchem-1058	61	63	.	.	PROPN
eurjchem-1058	62	1	5	5	NUM
eurjchem-1058	62	2	ml	ml	NOUN
eurjchem-1058	62	3	of	of	ADP
eurjchem-1058	62	4	this	this	DET
eurjchem-1058	62	5	solution	solution	NOUN
eurjchem-1058	62	6	was	be	AUX
eurjchem-1058	62	7	made	make	VERB
eurjchem-1058	62	8	up	up	ADP
eurjchem-1058	62	9	to	to	PART
eurjchem-1058	62	10	50	50	NUM
eurjchem-1058	62	11	ml	ml	NOUN
eurjchem-1058	62	12	with	with	ADP
eurjchem-1058	62	13	diluent	diluent	NOUN
eurjchem-1058	62	14	to	to	PART
eurjchem-1058	62	15	get	get	VERB
eurjchem-1058	62	16	a	a	DET
eurjchem-1058	62	17	concentration	concentration	NOUN
eurjchem-1058	62	18	of	of	ADP
eurjchem-1058	62	19	38	38	NUM
eurjchem-1058	62	20	µg	µg	NOUN
eurjchem-1058	62	21	/	/	SYM
eurjchem-1058	62	22	ml	ml	NOUN
eurjchem-1058	62	23	.	.	PUNCT
eurjchem-1058	63	1	this	this	DET
eurjchem-1058	63	2	impurity	impurity	NOUN
eurjchem-1058	63	3	stock	stock	NOUN
eurjchem-1058	63	4	solution	solution	NOUN
eurjchem-1058	63	5	was	be	AUX
eurjchem-1058	63	6	adequately	adequately	ADV
eurjchem-1058	63	7	diluted	dilute	VERB
eurjchem-1058	63	8	to	to	PART
eurjchem-1058	63	9	study	study	VERB
eurjchem-1058	63	10	accuracy	accuracy	NOUN
eurjchem-1058	63	11	,	,	PUNCT
eurjchem-1058	63	12	precision	precision	NOUN
eurjchem-1058	63	13	,	,	PUNCT
eurjchem-1058	63	14	linearity	linearity	NOUN
eurjchem-1058	63	15	,	,	PUNCT
eurjchem-1058	63	16	robustness	robustness	NOUN
eurjchem-1058	63	17	,	,	PUNCT
eurjchem-1058	63	18	limit	limit	NOUN
eurjchem-1058	63	19	of	of	ADP
eurjchem-1058	63	20	detection	detection	NOUN
eurjchem-1058	63	21	and	and	CCONJ
eurjchem-1058	63	22	quantitation	quantitation	NOUN
eurjchem-1058	63	23	.	.	PUNCT
eurjchem-1058	64	1	2.3.7	2.3.7	X
eurjchem-1058	64	2	.	.	PUNCT
eurjchem-1058	64	3	chromatographic	chromatographic	ADJ
eurjchem-1058	64	4	conditions	condition	NOUN
eurjchem-1058	64	5	to	to	PART
eurjchem-1058	64	6	develop	develop	VERB
eurjchem-1058	64	7	a	a	DET
eurjchem-1058	64	8	suitable	suitable	ADJ
eurjchem-1058	64	9	and	and	CCONJ
eurjchem-1058	64	10	robust	robust	ADJ
eurjchem-1058	64	11	rp‐hplc	rp‐hplc	ADJ
eurjchem-1058	64	12	method	method	NOUN
eurjchem-1058	64	13	for	for	ADP
eurjchem-1058	64	14	the	the	DET
eurjchem-1058	64	15	determination	determination	NOUN
eurjchem-1058	64	16	of	of	ADP
eurjchem-1058	64	17	pioglitazone	pioglitazone	NOUN
eurjchem-1058	64	18	hydrochloride	hydrochloride	NOUN
eurjchem-1058	64	19	and	and	CCONJ
eurjchem-1058	64	20	its	its	PRON
eurjchem-1058	64	21	process	process	NOUN
eurjchem-1058	64	22	related	relate	VERB
eurjchem-1058	64	23	impurities	impurity	NOUN
eurjchem-1058	64	24	,	,	PUNCT
eurjchem-1058	64	25	different	different	ADJ
eurjchem-1058	64	26	mobile	mobile	ADJ
eurjchem-1058	64	27	phases	phase	NOUN
eurjchem-1058	64	28	and	and	CCONJ
eurjchem-1058	64	29	columns	column	NOUN
eurjchem-1058	64	30	were	be	AUX
eurjchem-1058	64	31	employed	employ	VERB
eurjchem-1058	64	32	to	to	PART
eurjchem-1058	64	33	achieve	achieve	VERB
eurjchem-1058	64	34	the	the	DET
eurjchem-1058	64	35	best	good	ADJ
eurjchem-1058	64	36	separation	separation	NOUN
eurjchem-1058	64	37	and	and	CCONJ
eurjchem-1058	64	38	resolution	resolution	NOUN
eurjchem-1058	64	39	.	.	PUNCT
eurjchem-1058	65	1	the	the	DET
eurjchem-1058	65	2	method	method	PROPN
eurjchem-1058	65	3	development	development	NOUN
eurjchem-1058	65	4	was	be	AUX
eurjchem-1058	65	5	initiated	initiate	VERB
eurjchem-1058	65	6	with	with	ADP
eurjchem-1058	65	7	c18	c18	NOUN
eurjchem-1058	65	8	column	column	NOUN
eurjchem-1058	65	9	using	use	VERB
eurjchem-1058	65	10	a	a	DET
eurjchem-1058	65	11	mobile	mobile	ADJ
eurjchem-1058	65	12	phase	phase	NOUN
eurjchem-1058	65	13	containing	contain	VERB
eurjchem-1058	65	14	water	water	NOUN
eurjchem-1058	65	15	and	and	CCONJ
eurjchem-1058	65	16	acetonitrile	acetonitrile	NOUN
eurjchem-1058	65	17	as	as	ADP
eurjchem-1058	65	18	organic	organic	ADJ
eurjchem-1058	65	19	modifier	modifier	NOUN
eurjchem-1058	65	20	.	.	PUNCT
eurjchem-1058	66	1	broad	broad	ADJ
eurjchem-1058	66	2	peaks	peak	NOUN
eurjchem-1058	66	3	were	be	AUX
eurjchem-1058	66	4	observed	observe	VERB
eurjchem-1058	66	5	with	with	ADP
eurjchem-1058	66	6	this	this	DET
eurjchem-1058	66	7	mobile	mobile	ADJ
eurjchem-1058	66	8	phase	phase	NOUN
eurjchem-1058	66	9	.	.	PUNCT
eurjchem-1058	67	1	in	in	ADP
eurjchem-1058	67	2	the	the	DET
eurjchem-1058	67	3	above	above	ADJ
eurjchem-1058	67	4	mobile	mobile	ADJ
eurjchem-1058	67	5	phase	phase	NOUN
eurjchem-1058	67	6	water	water	NOUN
eurjchem-1058	67	7	was	be	AUX
eurjchem-1058	67	8	replaced	replace	VERB
eurjchem-1058	67	9	with	with	ADP
eurjchem-1058	67	10	phosphate	phosphate	ADJ
eurjchem-1058	67	11	buffer	buffer	NOUN
eurjchem-1058	67	12	.	.	PUNCT
eurjchem-1058	68	1	peak	peak	NOUN
eurjchem-1058	68	2	symmetry	symmetry	NOUN
eurjchem-1058	68	3	was	be	AUX
eurjchem-1058	68	4	not	not	PART
eurjchem-1058	68	5	good	good	ADJ
eurjchem-1058	68	6	.	.	PUNCT
eurjchem-1058	69	1	to	to	PART
eurjchem-1058	69	2	improve	improve	VERB
eurjchem-1058	69	3	the	the	DET
eurjchem-1058	69	4	peak	peak	NOUN
eurjchem-1058	69	5	shapes	shape	NOUN
eurjchem-1058	69	6	,	,	PUNCT
eurjchem-1058	69	7	ammonium	ammonium	NOUN
eurjchem-1058	69	8	acetate	acetate	NOUN
eurjchem-1058	69	9	buffer	buffer	NOUN
eurjchem-1058	69	10	was	be	AUX
eurjchem-1058	69	11	used	use	VERB
eurjchem-1058	69	12	in	in	ADP
eurjchem-1058	69	13	place	place	NOUN
eurjchem-1058	69	14	of	of	ADP
eurjchem-1058	69	15	phosphate	phosphate	ADJ
eurjchem-1058	69	16	buffer	buffer	NOUN
eurjchem-1058	69	17	.	.	PUNCT
eurjchem-1058	70	1	it	it	PRON
eurjchem-1058	70	2	gave	give	VERB
eurjchem-1058	70	3	sharp	sharp	ADJ
eurjchem-1058	70	4	peaks	peak	NOUN
eurjchem-1058	70	5	but	but	CCONJ
eurjchem-1058	70	6	the	the	DET
eurjchem-1058	70	7	problem	problem	NOUN
eurjchem-1058	70	8	is	be	AUX
eurjchem-1058	70	9	impurities	impurity	NOUN
eurjchem-1058	70	10	are	be	AUX
eurjchem-1058	70	11	merging	merge	VERB
eurjchem-1058	70	12	.	.	PUNCT
eurjchem-1058	71	1	compounds	compound	NOUN
eurjchem-1058	71	2	are	be	AUX
eurjchem-1058	71	3	having	have	VERB
eurjchem-1058	71	4	varying	vary	VERB
eurjchem-1058	71	5	polarities	polarity	NOUN
eurjchem-1058	71	6	.	.	PUNCT
eurjchem-1058	72	1	a	a	DET
eurjchem-1058	72	2	gradient	gradient	ADJ
eurjchem-1058	72	3	elution	elution	NOUN
eurjchem-1058	72	4	mode	mode	NOUN
eurjchem-1058	72	5	was	be	AUX
eurjchem-1058	72	6	tried	try	VERB
eurjchem-1058	72	7	;	;	PUNCT
eurjchem-1058	72	8	many	many	ADJ
eurjchem-1058	72	9	experiments	experiment	NOUN
eurjchem-1058	72	10	were	be	AUX
eurjchem-1058	72	11	conducted	conduct	VERB
eurjchem-1058	72	12	by	by	ADP
eurjchem-1058	72	13	using	use	VERB
eurjchem-1058	72	14	different	different	ADJ
eurjchem-1058	72	15	gradient	gradient	NOUN
eurjchem-1058	72	16	programs	program	NOUN
eurjchem-1058	72	17	and	and	CCONJ
eurjchem-1058	72	18	columns	column	NOUN
eurjchem-1058	72	19	while	while	SCONJ
eurjchem-1058	72	20	optimizing	optimize	VERB
eurjchem-1058	72	21	the	the	DET
eurjchem-1058	72	22	ph	ph	NOUN
eurjchem-1058	72	23	of	of	ADP
eurjchem-1058	72	24	buffer	buffer	NOUN
eurjchem-1058	72	25	,	,	PUNCT
eurjchem-1058	72	26	buffer	buffer	NOUN
eurjchem-1058	72	27	concentration	concentration	NOUN
eurjchem-1058	72	28	,	,	PUNCT
eurjchem-1058	72	29	organic	organic	ADJ
eurjchem-1058	72	30	modifier	modifier	NOUN
eurjchem-1058	72	31	strength	strength	NOUN
eurjchem-1058	72	32	and	and	CCONJ
eurjchem-1058	72	33	wavelength	wavelength	NOUN
eurjchem-1058	72	34	.	.	PUNCT
eurjchem-1058	73	1	finally	finally	ADV
eurjchem-1058	73	2	the	the	DET
eurjchem-1058	73	3	best	good	ADJ
eurjchem-1058	73	4	results	result	NOUN
eurjchem-1058	73	5	were	be	AUX
eurjchem-1058	73	6	observed	observe	VERB
eurjchem-1058	73	7	using	use	VERB
eurjchem-1058	73	8	a	a	DET
eurjchem-1058	73	9	column	column	NOUN
eurjchem-1058	73	10	c18	c18	NOUN
eurjchem-1058	73	11	ods	ods	PROPN
eurjchem-1058	73	12	(	(	PUNCT
eurjchem-1058	73	13	150	150	NUM
eurjchem-1058	73	14	×	×	NOUN
eurjchem-1058	73	15	4.6	4.6	NUM
eurjchem-1058	73	16	mm	mm	NOUN
eurjchem-1058	73	17	)	)	PUNCT
eurjchem-1058	73	18	,	,	PUNCT
eurjchem-1058	73	19	mobile	mobile	ADJ
eurjchem-1058	73	20	phase	phase	NOUN
eurjchem-1058	73	21	consisting	consist	VERB
eurjchem-1058	73	22	of	of	ADP
eurjchem-1058	73	23	solvent	solvent	NOUN
eurjchem-1058	73	24	a	a	DET
eurjchem-1058	73	25	:	:	PUNCT
eurjchem-1058	73	26	ammonium	ammonium	NOUN
eurjchem-1058	73	27	acetate	acetate	NOUN
eurjchem-1058	73	28	buffer	buffer	NOUN
eurjchem-1058	73	29	and	and	CCONJ
eurjchem-1058	73	30	acetonitrile	acetonitrile	NOUN
eurjchem-1058	73	31	in	in	ADP
eurjchem-1058	73	32	the	the	DET
eurjchem-1058	73	33	ratio	ratio	NOUN
eurjchem-1058	73	34	(	(	PUNCT
eurjchem-1058	73	35	57:43	57:43	NUM
eurjchem-1058	73	36	,	,	PUNCT
eurjchem-1058	73	37	v	v	NOUN
eurjchem-1058	73	38	:	:	PUNCT
eurjchem-1058	73	39	v	v	NOUN
eurjchem-1058	73	40	)	)	PUNCT
eurjchem-1058	73	41	.	.	PUNCT
eurjchem-1058	74	1	prava	prava	PROPN
eurjchem-1058	74	2	and	and	CCONJ
eurjchem-1058	74	3	seru	seru	PROPN
eurjchem-1058	74	4	/	/	SYM
eurjchem-1058	74	5	european	european	PROPN
eurjchem-1058	74	6	journal	journal	PROPN
eurjchem-1058	74	7	of	of	ADP
eurjchem-1058	74	8	chemistry	chemistry	NOUN
eurjchem-1058	74	9	5	5	NUM
eurjchem-1058	74	10	(	(	PUNCT
eurjchem-1058	74	11	3	3	NUM
eurjchem-1058	74	12	)	)	PUNCT
eurjchem-1058	74	13	(	(	PUNCT
eurjchem-1058	74	14	2014	2014	NUM
eurjchem-1058	74	15	)	)	PUNCT
eurjchem-1058	74	16	469‐474	469‐474	PROPN
eurjchem-1058	74	17	471	471	NUM
eurjchem-1058	74	18	table	table	NOUN
eurjchem-1058	74	19	1	1	NUM
eurjchem-1058	74	20	.	.	PUNCT
eurjchem-1058	74	21	system	system	NOUN
eurjchem-1058	74	22	suitability	suitability	NOUN
eurjchem-1058	74	23	data	datum	NOUN
eurjchem-1058	74	24	.	.	PUNCT
eurjchem-1058	75	1	name	name	PROPN
eurjchem-1058	75	2	rt	rt	PROPN
eurjchem-1058	75	3	rrt	rrt	NOUN
eurjchem-1058	75	4	resolution	resolution	NOUN
eurjchem-1058	75	5	(	(	PUNCT
eurjchem-1058	75	6	rs	rs	NOUN
eurjchem-1058	75	7	)	)	PUNCT
eurjchem-1058	75	8	theoretical	theoretical	ADJ
eurjchem-1058	75	9	plates	plate	NOUN
eurjchem-1058	75	10	(	(	PUNCT
eurjchem-1058	75	11	n	n	CCONJ
eurjchem-1058	75	12	)	)	PUNCT
eurjchem-1058	75	13	peak	peak	NOUN
eurjchem-1058	75	14	symmetry	symmetry	NOUN
eurjchem-1058	75	15	(	(	PUNCT
eurjchem-1058	75	16	as	as	ADP
eurjchem-1058	75	17	)	)	PUNCT
eurjchem-1058	75	18	impurity‐a	impurity‐a	VERB
eurjchem-1058	75	19	3.478	3.478	NUM
eurjchem-1058	75	20	0.41	0.41	NUM
eurjchem-1058	75	21	‐	‐	ADP
eurjchem-1058	75	22	2944.3	2944.3	NUM
eurjchem-1058	75	23	1.1	1.1	NUM
eurjchem-1058	75	24	impurity‐b	impurity‐b	NOUN
eurjchem-1058	75	25	10.770	10.770	NUM
eurjchem-1058	75	26	1.28	1.28	NUM
eurjchem-1058	75	27	5.8	5.8	NUM
eurjchem-1058	75	28	13461	13461	NUM
eurjchem-1058	75	29	1.0	1.0	NUM
eurjchem-1058	75	30	impurity‐c	impurity‐c	PROPN
eurjchem-1058	75	31	18.000	18.000	NUM
eurjchem-1058	75	32	2.15	2.15	NUM
eurjchem-1058	75	33	25.1	25.1	NUM
eurjchem-1058	75	34	122171.6	122171.6	NUM
eurjchem-1058	75	35	1.1	1.1	NUM
eurjchem-1058	75	36	pioglitazone	pioglitazone	NOUN
eurjchem-1058	75	37	hydrochloride	hydrochloride	NOUN
eurjchem-1058	75	38	8.436	8.436	NUM
eurjchem-1058	75	39	1.06	1.06	NUM
eurjchem-1058	75	40	14.1	14.1	NUM
eurjchem-1058	75	41	5622.5	5622.5	NUM
eurjchem-1058	75	42	1.0	1.0	NUM
eurjchem-1058	75	43	table	table	NOUN
eurjchem-1058	75	44	2	2	NUM
eurjchem-1058	75	45	.	.	X
eurjchem-1058	75	46	linearity	linearity	NOUN
eurjchem-1058	75	47	for	for	ADP
eurjchem-1058	75	48	impurity‐a	impurity‐a	PROPN
eurjchem-1058	75	49	.	.	PUNCT
eurjchem-1058	76	1	sample	sample	VERB
eurjchem-1058	76	2	no	no	DET
eurjchem-1058	76	3	concentration	concentration	NOUN
eurjchem-1058	76	4	(	(	PUNCT
eurjchem-1058	76	5	µg	µg	NOUN
eurjchem-1058	76	6	/	/	SYM
eurjchem-1058	76	7	ml	ml	NOUN
eurjchem-1058	76	8	)	)	PUNCT
eurjchem-1058	76	9	peak	peak	NOUN
eurjchem-1058	76	10	area	area	NOUN
eurjchem-1058	76	11	mean	mean	VERB
eurjchem-1058	76	12	peak	peak	NOUN
eurjchem-1058	76	13	area	area	NOUN
eurjchem-1058	76	14	1	1	NUM
eurjchem-1058	76	15	0.187	0.187	NUM
eurjchem-1058	76	16	6144	6144	NUM
eurjchem-1058	76	17	6246	6246	NUM
eurjchem-1058	76	18	6533	6533	NUM
eurjchem-1058	77	1	6307.6	6307.6	NUM
eurjchem-1058	77	2	2	2	NUM
eurjchem-1058	77	3	0.374	0.374	NUM
eurjchem-1058	77	4	12331	12331	NUM
eurjchem-1058	77	5	12381	12381	NUM
eurjchem-1058	77	6	12152	12152	NUM
eurjchem-1058	77	7	12288	12288	NUM
eurjchem-1058	77	8	3	3	NUM
eurjchem-1058	77	9	0.748	0.748	NUM
eurjchem-1058	77	10	22932	22932	NUM
eurjchem-1058	77	11	23435	23435	NUM
eurjchem-1058	77	12	23277	23277	NUM
eurjchem-1058	77	13	23214.7	23214.7	NUM
eurjchem-1058	77	14	4	4	NUM
eurjchem-1058	77	15	1.122	1.122	NUM
eurjchem-1058	77	16	37399	37399	NUM
eurjchem-1058	77	17	37439	37439	NUM
eurjchem-1058	77	18	37409	37409	NUM
eurjchem-1058	77	19	37415.7	37415.7	NUM
eurjchem-1058	77	20	5	5	NUM
eurjchem-1058	77	21	1.496	1.496	NUM
eurjchem-1058	77	22	49598	49598	NUM
eurjchem-1058	77	23	49859	49859	NUM
eurjchem-1058	77	24	50112	50112	NUM
eurjchem-1058	77	25	49856.3	49856.3	NUM
eurjchem-1058	77	26	6	6	NUM
eurjchem-1058	77	27	1.875	1.875	NUM
eurjchem-1058	77	28	64068	64068	NUM
eurjchem-1058	77	29	65395	65395	NUM
eurjchem-1058	77	30	65055	65055	NUM
eurjchem-1058	77	31	64839.3	64839.3	NUM
eurjchem-1058	77	32	7	7	NUM
eurjchem-1058	77	33	2.244	2.244	NUM
eurjchem-1058	77	34	76150	76150	NUM
eurjchem-1058	77	35	76795	76795	NUM
eurjchem-1058	77	36	76272	76272	NUM
eurjchem-1058	77	37	76405.67	76405.67	NUM
eurjchem-1058	77	38	correlation	correlation	NOUN
eurjchem-1058	77	39	coefficient	coefficient	NOUN
eurjchem-1058	77	40	0.9986	0.9986	NUM
eurjchem-1058	77	41	slope	slope	NOUN
eurjchem-1058	77	42	34558	34558	NUM
eurjchem-1058	77	43	intercept	intercept	NOUN
eurjchem-1058	77	44	‐1078.9	‐1078.9	PROPN
eurjchem-1058	77	45	solvent	solvent	ADJ
eurjchem-1058	77	46	b	b	NOUN
eurjchem-1058	77	47	:	:	PUNCT
eurjchem-1058	77	48	ammonium	ammonium	NOUN
eurjchem-1058	77	49	acetate	acetate	NOUN
eurjchem-1058	77	50	buffer	buffer	NOUN
eurjchem-1058	77	51	and	and	CCONJ
eurjchem-1058	77	52	acetonitrile	acetonitrile	NOUN
eurjchem-1058	77	53	in	in	ADP
eurjchem-1058	77	54	the	the	DET
eurjchem-1058	77	55	ratio	ratio	NOUN
eurjchem-1058	77	56	(	(	PUNCT
eurjchem-1058	77	57	20:80	20:80	NUM
eurjchem-1058	77	58	,	,	PUNCT
eurjchem-1058	77	59	v	v	NOUN
eurjchem-1058	77	60	:	:	PUNCT
eurjchem-1058	77	61	v	v	NOUN
eurjchem-1058	77	62	)	)	PUNCT
eurjchem-1058	77	63	at	at	ADP
eurjchem-1058	77	64	a	a	DET
eurjchem-1058	77	65	flow	flow	NOUN
eurjchem-1058	77	66	rate	rate	NOUN
eurjchem-1058	77	67	of	of	ADP
eurjchem-1058	77	68	1.0	1.0	NUM
eurjchem-1058	77	69	ml	ml	NOUN
eurjchem-1058	77	70	/	/	SYM
eurjchem-1058	77	71	min	min	NOUN
eurjchem-1058	77	72	.	.	PROPN
eurjchem-1058	77	73	according	accord	VERB
eurjchem-1058	77	74	to	to	ADP
eurjchem-1058	77	75	gradient	gradient	ADJ
eurjchem-1058	77	76	elution	elution	NOUN
eurjchem-1058	77	77	program	program	NOUN
eurjchem-1058	77	78	0‐7	0‐7	NOUN
eurjchem-1058	77	79	min	min	NOUN
eurjchem-1058	77	80	(	(	PUNCT
eurjchem-1058	77	81	100	100	NUM
eurjchem-1058	77	82	%	%	NOUN
eurjchem-1058	77	83	a	a	NOUN
eurjchem-1058	77	84	)	)	PUNCT
eurjchem-1058	77	85	,	,	PUNCT
eurjchem-1058	77	86	7‐20	7‐20	NUM
eurjchem-1058	77	87	min	min	NOUN
eurjchem-1058	77	88	(	(	PUNCT
eurjchem-1058	77	89	100	100	NUM
eurjchem-1058	77	90	%	%	NOUN
eurjchem-1058	77	91	b	b	NOUN
eurjchem-1058	77	92	)	)	PUNCT
eurjchem-1058	77	93	,	,	PUNCT
eurjchem-1058	77	94	20‐21	20‐21	NUM
eurjchem-1058	77	95	min	min	NOUN
eurjchem-1058	77	96	(	(	PUNCT
eurjchem-1058	77	97	100	100	NUM
eurjchem-1058	77	98	%	%	NOUN
eurjchem-1058	77	99	a	a	NOUN
eurjchem-1058	77	100	)	)	PUNCT
eurjchem-1058	77	101	.	.	PUNCT
eurjchem-1058	78	1	in	in	ADP
eurjchem-1058	78	2	the	the	DET
eurjchem-1058	78	3	above	above	ADJ
eurjchem-1058	78	4	chromatographic	chromatographic	ADJ
eurjchem-1058	78	5	conditions	condition	NOUN
eurjchem-1058	78	6	gave	give	VERB
eurjchem-1058	78	7	sharp	sharp	ADJ
eurjchem-1058	78	8	peaks	peak	NOUN
eurjchem-1058	78	9	with	with	ADP
eurjchem-1058	78	10	minimum	minimum	NOUN
eurjchem-1058	78	11	tailing	tailing	NOUN
eurjchem-1058	78	12	,	,	PUNCT
eurjchem-1058	78	13	good	good	ADJ
eurjchem-1058	78	14	resolution	resolution	NOUN
eurjchem-1058	78	15	and	and	CCONJ
eurjchem-1058	78	16	shorter	short	ADJ
eurjchem-1058	78	17	runtime	runtime	NOUN
eurjchem-1058	78	18	for	for	ADP
eurjchem-1058	78	19	pioglitazone	pioglitazone	NOUN
eurjchem-1058	78	20	hydrochloride	hydrochloride	NOUN
eurjchem-1058	78	21	and	and	CCONJ
eurjchem-1058	78	22	its	its	PRON
eurjchem-1058	78	23	process	process	NOUN
eurjchem-1058	78	24	related	relate	VERB
eurjchem-1058	78	25	impurities	impurity	NOUN
eurjchem-1058	78	26	(	(	PUNCT
eurjchem-1058	78	27	figure	figure	NOUN
eurjchem-1058	78	28	2	2	NUM
eurjchem-1058	78	29	)	)	PUNCT
eurjchem-1058	78	30	.	.	PUNCT
eurjchem-1058	79	1	figure	figure	NOUN
eurjchem-1058	79	2	2	2	NUM
eurjchem-1058	79	3	.	.	PUNCT
eurjchem-1058	79	4	typical	typical	ADJ
eurjchem-1058	79	5	chromatogram	chromatogram	PROPN
eurjchem-1058	79	6	for	for	ADP
eurjchem-1058	79	7	loq	loq	PROPN
eurjchem-1058	79	8	.	.	PUNCT
eurjchem-1058	80	1	3	3	X
eurjchem-1058	80	2	.	.	NOUN
eurjchem-1058	80	3	results	result	NOUN
eurjchem-1058	80	4	and	and	CCONJ
eurjchem-1058	80	5	discussion	discussion	NOUN
eurjchem-1058	80	6	analytical	analytical	ADJ
eurjchem-1058	80	7	method	method	NOUN
eurjchem-1058	80	8	validation	validation	NOUN
eurjchem-1058	80	9	is	be	AUX
eurjchem-1058	80	10	a	a	DET
eurjchem-1058	80	11	process	process	NOUN
eurjchem-1058	80	12	that	that	PRON
eurjchem-1058	80	13	demonstrates	demonstrate	VERB
eurjchem-1058	80	14	the	the	DET
eurjchem-1058	80	15	suitability	suitability	NOUN
eurjchem-1058	80	16	of	of	ADP
eurjchem-1058	80	17	the	the	DET
eurjchem-1058	80	18	proposed	propose	VERB
eurjchem-1058	80	19	procedures	procedure	NOUN
eurjchem-1058	80	20	for	for	ADP
eurjchem-1058	80	21	the	the	DET
eurjchem-1058	80	22	intended	intended	ADJ
eurjchem-1058	80	23	purpose	purpose	NOUN
eurjchem-1058	80	24	.	.	PUNCT
eurjchem-1058	81	1	more	more	ADV
eurjchem-1058	81	2	specifically	specifically	ADV
eurjchem-1058	81	3	,	,	PUNCT
eurjchem-1058	81	4	it	it	PRON
eurjchem-1058	81	5	is	be	AUX
eurjchem-1058	81	6	a	a	DET
eurjchem-1058	81	7	matter	matter	NOUN
eurjchem-1058	81	8	of	of	ADP
eurjchem-1058	81	9	establishing	establish	VERB
eurjchem-1058	81	10	documented	document	VERB
eurjchem-1058	81	11	evidence	evidence	NOUN
eurjchem-1058	81	12	providing	provide	VERB
eurjchem-1058	81	13	a	a	DET
eurjchem-1058	81	14	high	high	ADJ
eurjchem-1058	81	15	degree	degree	NOUN
eurjchem-1058	81	16	of	of	ADP
eurjchem-1058	81	17	assurance	assurance	NOUN
eurjchem-1058	81	18	with	with	ADP
eurjchem-1058	81	19	respect	respect	NOUN
eurjchem-1058	81	20	to	to	ADP
eurjchem-1058	81	21	the	the	DET
eurjchem-1058	81	22	consistency	consistency	NOUN
eurjchem-1058	81	23	of	of	ADP
eurjchem-1058	81	24	the	the	DET
eurjchem-1058	81	25	method	method	NOUN
eurjchem-1058	81	26	and	and	CCONJ
eurjchem-1058	81	27	results	result	NOUN
eurjchem-1058	81	28	to	to	PART
eurjchem-1058	81	29	evaluate	evaluate	VERB
eurjchem-1058	81	30	the	the	DET
eurjchem-1058	81	31	product	product	NOUN
eurjchem-1058	81	32	against	against	ADP
eurjchem-1058	81	33	defined	define	VERB
eurjchem-1058	81	34	specifications	specification	NOUN
eurjchem-1058	81	35	.	.	PUNCT
eurjchem-1058	82	1	the	the	DET
eurjchem-1058	82	2	validation	validation	NOUN
eurjchem-1058	82	3	parameters	parameter	NOUN
eurjchem-1058	82	4	viz	viz	VERB
eurjchem-1058	82	5	.	.	PROPN
eurjchem-1058	82	6	,	,	PUNCT
eurjchem-1058	82	7	specificity	specificity	NOUN
eurjchem-1058	82	8	,	,	PUNCT
eurjchem-1058	82	9	accuracy	accuracy	NOUN
eurjchem-1058	82	10	,	,	PUNCT
eurjchem-1058	82	11	precision	precision	NOUN
eurjchem-1058	82	12	,	,	PUNCT
eurjchem-1058	82	13	linearity	linearity	NOUN
eurjchem-1058	82	14	,	,	PUNCT
eurjchem-1058	82	15	limit	limit	NOUN
eurjchem-1058	82	16	of	of	ADP
eurjchem-1058	82	17	detection	detection	NOUN
eurjchem-1058	82	18	,	,	PUNCT
eurjchem-1058	82	19	limit	limit	NOUN
eurjchem-1058	82	20	of	of	ADP
eurjchem-1058	82	21	quantitation	quantitation	NOUN
eurjchem-1058	82	22	,	,	PUNCT
eurjchem-1058	82	23	robustness	robustness	NOUN
eurjchem-1058	82	24	,	,	PUNCT
eurjchem-1058	82	25	system	system	NOUN
eurjchem-1058	82	26	suitability	suitability	NOUN
eurjchem-1058	82	27	have	have	VERB
eurjchem-1058	82	28	to	to	PART
eurjchem-1058	82	29	be	be	AUX
eurjchem-1058	82	30	evaluated	evaluate	VERB
eurjchem-1058	82	31	as	as	ADP
eurjchem-1058	82	32	per	per	ADP
eurjchem-1058	82	33	the	the	DET
eurjchem-1058	82	34	ich	ich	NOUN
eurjchem-1058	82	35	guidelines	guideline	NOUN
eurjchem-1058	82	36	for	for	ADP
eurjchem-1058	82	37	all	all	DET
eurjchem-1058	82	38	analytical	analytical	ADJ
eurjchem-1058	82	39	methods	method	NOUN
eurjchem-1058	82	40	developed	develop	VERB
eurjchem-1058	82	41	by	by	ADP
eurjchem-1058	82	42	hplc	hplc	PROPN
eurjchem-1058	82	43	.	.	PUNCT
eurjchem-1058	83	1	3.1	3.1	NUM
eurjchem-1058	83	2	.	.	PUNCT
eurjchem-1058	83	3	system	system	NOUN
eurjchem-1058	83	4	suitability	suitability	NOUN
eurjchem-1058	83	5	this	this	PRON
eurjchem-1058	83	6	is	be	AUX
eurjchem-1058	83	7	an	an	DET
eurjchem-1058	83	8	integral	integral	ADJ
eurjchem-1058	83	9	part	part	NOUN
eurjchem-1058	83	10	of	of	ADP
eurjchem-1058	83	11	development	development	NOUN
eurjchem-1058	83	12	of	of	ADP
eurjchem-1058	83	13	a	a	DET
eurjchem-1058	83	14	chromatographic	chromatographic	ADJ
eurjchem-1058	83	15	method	method	NOUN
eurjchem-1058	83	16	to	to	PART
eurjchem-1058	83	17	verify	verify	VERB
eurjchem-1058	83	18	that	that	SCONJ
eurjchem-1058	83	19	the	the	DET
eurjchem-1058	83	20	resolution	resolution	NOUN
eurjchem-1058	83	21	and	and	CCONJ
eurjchem-1058	83	22	reproducibility	reproducibility	NOUN
eurjchem-1058	83	23	of	of	ADP
eurjchem-1058	83	24	the	the	DET
eurjchem-1058	83	25	system	system	NOUN
eurjchem-1058	83	26	are	be	AUX
eurjchem-1058	83	27	adequate	adequate	ADJ
eurjchem-1058	83	28	enough	enough	ADV
eurjchem-1058	83	29	for	for	SCONJ
eurjchem-1058	83	30	the	the	DET
eurjchem-1058	83	31	analysis	analysis	NOUN
eurjchem-1058	83	32	to	to	PART
eurjchem-1058	83	33	be	be	AUX
eurjchem-1058	83	34	performed	perform	VERB
eurjchem-1058	83	35	.	.	PUNCT
eurjchem-1058	84	1	it	it	PRON
eurjchem-1058	84	2	is	be	AUX
eurjchem-1058	84	3	based	base	VERB
eurjchem-1058	84	4	on	on	ADP
eurjchem-1058	84	5	the	the	DET
eurjchem-1058	84	6	concept	concept	NOUN
eurjchem-1058	84	7	that	that	SCONJ
eurjchem-1058	84	8	the	the	DET
eurjchem-1058	84	9	equipment	equipment	NOUN
eurjchem-1058	84	10	,	,	PUNCT
eurjchem-1058	84	11	electronics	electronic	NOUN
eurjchem-1058	84	12	,	,	PUNCT
eurjchem-1058	84	13	analytical	analytical	ADJ
eurjchem-1058	84	14	operations	operation	NOUN
eurjchem-1058	84	15	and	and	CCONJ
eurjchem-1058	84	16	samples	sample	NOUN
eurjchem-1058	84	17	constituting	constitute	VERB
eurjchem-1058	84	18	an	an	DET
eurjchem-1058	84	19	integral	integral	ADJ
eurjchem-1058	84	20	system	system	NOUN
eurjchem-1058	84	21	could	could	AUX
eurjchem-1058	84	22	be	be	AUX
eurjchem-1058	84	23	evaluated	evaluate	VERB
eurjchem-1058	84	24	as	as	ADP
eurjchem-1058	84	25	a	a	DET
eurjchem-1058	84	26	whole	whole	NOUN
eurjchem-1058	84	27	.	.	PUNCT
eurjchem-1058	85	1	parameters	parameter	NOUN
eurjchem-1058	85	2	such	such	ADJ
eurjchem-1058	85	3	as	as	ADP
eurjchem-1058	85	4	plate	plate	NOUN
eurjchem-1058	85	5	number	number	NOUN
eurjchem-1058	85	6	(	(	PUNCT
eurjchem-1058	85	7	n	n	CCONJ
eurjchem-1058	85	8	)	)	PUNCT
eurjchem-1058	85	9	,	,	PUNCT
eurjchem-1058	85	10	asymmetry	asymmetry	NOUN
eurjchem-1058	85	11	or	or	CCONJ
eurjchem-1058	85	12	tailing	tail	VERB
eurjchem-1058	85	13	factors	factor	NOUN
eurjchem-1058	85	14	(	(	PUNCT
eurjchem-1058	85	15	as	as	ADP
eurjchem-1058	85	16	)	)	PUNCT
eurjchem-1058	85	17	,	,	PUNCT
eurjchem-1058	85	18	relative	relative	ADJ
eurjchem-1058	85	19	retention	retention	NOUN
eurjchem-1058	85	20	time	time	NOUN
eurjchem-1058	85	21	(	(	PUNCT
eurjchem-1058	85	22	rrt	rrt	NOUN
eurjchem-1058	85	23	)	)	PUNCT
eurjchem-1058	85	24	,	,	PUNCT
eurjchem-1058	85	25	resolution	resolution	NOUN
eurjchem-1058	85	26	(	(	PUNCT
eurjchem-1058	85	27	rs	rs	NOUN
eurjchem-1058	85	28	)	)	PUNCT
eurjchem-1058	85	29	and	and	CCONJ
eurjchem-1058	85	30	reproducibility	reproducibility	NOUN
eurjchem-1058	85	31	(	(	PUNCT
eurjchem-1058	85	32	%	%	INTJ
eurjchem-1058	85	33	r.s.d	r.s.d	NOUN
eurjchem-1058	85	34	)	)	PUNCT
eurjchem-1058	85	35	,	,	PUNCT
eurjchem-1058	85	36	retention	retention	NOUN
eurjchem-1058	85	37	time	time	NOUN
eurjchem-1058	85	38	were	be	AUX
eurjchem-1058	85	39	determined	determine	VERB
eurjchem-1058	85	40	(	(	PUNCT
eurjchem-1058	85	41	table	table	NOUN
eurjchem-1058	85	42	1	1	NUM
eurjchem-1058	85	43	)	)	PUNCT
eurjchem-1058	85	44	.	.	PUNCT
eurjchem-1058	86	1	these	these	DET
eurjchem-1058	86	2	parameters	parameter	NOUN
eurjchem-1058	86	3	were	be	AUX
eurjchem-1058	86	4	determined	determine	VERB
eurjchem-1058	86	5	during	during	ADP
eurjchem-1058	86	6	the	the	DET
eurjchem-1058	86	7	analysis	analysis	NOUN
eurjchem-1058	86	8	of	of	ADP
eurjchem-1058	86	9	a	a	DET
eurjchem-1058	86	10	"	"	PUNCT
eurjchem-1058	86	11	sample	sample	NOUN
eurjchem-1058	86	12	"	"	PUNCT
eurjchem-1058	86	13	containing	contain	VERB
eurjchem-1058	86	14	the	the	DET
eurjchem-1058	86	15	main	main	ADJ
eurjchem-1058	86	16	components	component	NOUN
eurjchem-1058	86	17	and	and	CCONJ
eurjchem-1058	86	18	related	related	ADJ
eurjchem-1058	86	19	substances	substance	NOUN
eurjchem-1058	86	20	.	.	PUNCT
eurjchem-1058	87	1	system	system	NOUN
eurjchem-1058	87	2	suitability	suitability	NOUN
eurjchem-1058	87	3	parameters	parameter	NOUN
eurjchem-1058	87	4	were	be	AUX
eurjchem-1058	87	5	determined	determine	VERB
eurjchem-1058	87	6	and	and	CCONJ
eurjchem-1058	87	7	compared	compare	VERB
eurjchem-1058	87	8	with	with	ADP
eurjchem-1058	87	9	the	the	DET
eurjchem-1058	87	10	recommended	recommend	VERB
eurjchem-1058	87	11	limits	limit	NOUN
eurjchem-1058	87	12	(	(	PUNCT
eurjchem-1058	87	13	1	1	NUM
eurjchem-1058	87	14	≥	≥	NOUN
eurjchem-1058	87	15	as	as	ADP
eurjchem-1058	87	16	≤	≤	NUM
eurjchem-1058	87	17	2	2	NUM
eurjchem-1058	87	18	and	and	CCONJ
eurjchem-1058	87	19	rs	rs	ADJ
eurjchem-1058	87	20	>	>	X
eurjchem-1058	87	21	1.5	1.5	NUM
eurjchem-1058	87	22	)	)	PUNCT
eurjchem-1058	87	23	.	.	PUNCT
eurjchem-1058	88	1	3.2	3.2	NUM
eurjchem-1058	88	2	.	.	PUNCT
eurjchem-1058	89	1	specificity	specificity	NOUN
eurjchem-1058	89	2	specificity	specificity	NOUN
eurjchem-1058	89	3	is	be	AUX
eurjchem-1058	89	4	the	the	DET
eurjchem-1058	89	5	ability	ability	NOUN
eurjchem-1058	89	6	of	of	ADP
eurjchem-1058	89	7	the	the	DET
eurjchem-1058	89	8	method	method	NOUN
eurjchem-1058	89	9	to	to	PART
eurjchem-1058	89	10	measure	measure	VERB
eurjchem-1058	89	11	the	the	DET
eurjchem-1058	89	12	analyte	analyte	NOUN
eurjchem-1058	89	13	response	response	NOUN
eurjchem-1058	89	14	in	in	ADP
eurjchem-1058	89	15	presence	presence	NOUN
eurjchem-1058	89	16	of	of	ADP
eurjchem-1058	89	17	its	its	PRON
eurjchem-1058	89	18	process	process	NOUN
eurjchem-1058	89	19	related	relate	VERB
eurjchem-1058	89	20	impurities	impurity	NOUN
eurjchem-1058	89	21	.	.	PUNCT
eurjchem-1058	90	1	the	the	DET
eurjchem-1058	90	2	specificity	specificity	NOUN
eurjchem-1058	90	3	of	of	ADP
eurjchem-1058	90	4	the	the	DET
eurjchem-1058	90	5	developed	develop	VERB
eurjchem-1058	90	6	hplc	hplc	NOUN
eurjchem-1058	90	7	method	method	NOUN
eurjchem-1058	90	8	was	be	AUX
eurjchem-1058	90	9	performed	perform	VERB
eurjchem-1058	90	10	by	by	ADP
eurjchem-1058	90	11	injecting	inject	VERB
eurjchem-1058	90	12	blank	blank	ADJ
eurjchem-1058	90	13	solution	solution	NOUN
eurjchem-1058	90	14	and	and	CCONJ
eurjchem-1058	90	15	standard	standard	ADJ
eurjchem-1058	90	16	solution	solution	NOUN
eurjchem-1058	90	17	spiked	spike	VERB
eurjchem-1058	90	18	with	with	ADP
eurjchem-1058	90	19	process‐related	process‐related	ADJ
eurjchem-1058	90	20	impurities	impurity	NOUN
eurjchem-1058	90	21	separately	separately	ADV
eurjchem-1058	90	22	.	.	PUNCT
eurjchem-1058	91	1	the	the	DET
eurjchem-1058	91	2	chromatogram	chromatogram	NOUN
eurjchem-1058	91	3	of	of	ADP
eurjchem-1058	91	4	drug	drug	NOUN
eurjchem-1058	91	5	with	with	ADP
eurjchem-1058	91	6	impurities	impurity	NOUN
eurjchem-1058	91	7	was	be	AUX
eurjchem-1058	91	8	compared	compare	VERB
eurjchem-1058	91	9	with	with	ADP
eurjchem-1058	91	10	the	the	DET
eurjchem-1058	91	11	blank	blank	ADJ
eurjchem-1058	91	12	chromatogram	chromatogram	NOUN
eurjchem-1058	91	13	,	,	PUNCT
eurjchem-1058	91	14	to	to	PART
eurjchem-1058	91	15	verify	verify	VERB
eurjchem-1058	91	16	the	the	DET
eurjchem-1058	91	17	blank	blank	ADJ
eurjchem-1058	91	18	interference	interference	NOUN
eurjchem-1058	91	19	.	.	PUNCT
eurjchem-1058	92	1	no	no	DET
eurjchem-1058	92	2	peak	peak	NOUN
eurjchem-1058	92	3	was	be	AUX
eurjchem-1058	92	4	observed	observe	VERB
eurjchem-1058	92	5	at	at	ADP
eurjchem-1058	92	6	the	the	DET
eurjchem-1058	92	7	retention	retention	NOUN
eurjchem-1058	92	8	time	time	NOUN
eurjchem-1058	92	9	of	of	ADP
eurjchem-1058	92	10	pioglitazone	pioglitazone	NOUN
eurjchem-1058	92	11	hydrochloride	hydrochloride	NOUN
eurjchem-1058	92	12	and	and	CCONJ
eurjchem-1058	92	13	its	its	PRON
eurjchem-1058	92	14	impurities	impurity	NOUN
eurjchem-1058	92	15	.	.	PUNCT
eurjchem-1058	93	1	hence	hence	ADV
eurjchem-1058	93	2	the	the	DET
eurjchem-1058	93	3	method	method	NOUN
eurjchem-1058	93	4	is	be	AUX
eurjchem-1058	93	5	specific	specific	ADJ
eurjchem-1058	93	6	for	for	ADP
eurjchem-1058	93	7	the	the	DET
eurjchem-1058	93	8	determination	determination	NOUN
eurjchem-1058	93	9	of	of	ADP
eurjchem-1058	93	10	process	process	NOUN
eurjchem-1058	93	11	related	relate	VERB
eurjchem-1058	93	12	impurities	impurity	NOUN
eurjchem-1058	93	13	in	in	ADP
eurjchem-1058	93	14	pioglitazone	pioglitazone	NOUN
eurjchem-1058	93	15	hydrochloride	hydrochloride	NOUN
eurjchem-1058	93	16	.	.	PUNCT
eurjchem-1058	94	1	3.3	3.3	NUM
eurjchem-1058	94	2	.	.	PUNCT
eurjchem-1058	95	1	linearity	linearity	PROPN
eurjchem-1058	95	2	standard	standard	ADJ
eurjchem-1058	95	3	solutions	solution	NOUN
eurjchem-1058	95	4	at	at	ADP
eurjchem-1058	95	5	different	different	ADJ
eurjchem-1058	95	6	concentration	concentration	NOUN
eurjchem-1058	95	7	levels	level	NOUN
eurjchem-1058	95	8	ranging	range	VERB
eurjchem-1058	95	9	from	from	ADP
eurjchem-1058	95	10	loq	loq	PROPN
eurjchem-1058	95	11	to	to	ADP
eurjchem-1058	95	12	2.25	2.25	NUM
eurjchem-1058	95	13	μg	μg	NOUN
eurjchem-1058	95	14	/	/	SYM
eurjchem-1058	95	15	ml	ml	PROPN
eurjchem-1058	95	16	(	(	PUNCT
eurjchem-1058	95	17	150	150	NUM
eurjchem-1058	95	18	%	%	NOUN
eurjchem-1058	95	19	of	of	ADP
eurjchem-1058	95	20	specification	specification	NOUN
eurjchem-1058	95	21	limit	limit	NOUN
eurjchem-1058	95	22	)	)	PUNCT
eurjchem-1058	95	23	were	be	AUX
eurjchem-1058	95	24	prepared	prepare	VERB
eurjchem-1058	95	25	and	and	CCONJ
eurjchem-1058	95	26	analyzed	analyze	VERB
eurjchem-1058	95	27	in	in	ADP
eurjchem-1058	95	28	triplicate	triplicate	NOUN
eurjchem-1058	95	29	.	.	PUNCT
eurjchem-1058	96	1	in	in	ADP
eurjchem-1058	96	2	order	order	NOUN
eurjchem-1058	96	3	to	to	PART
eurjchem-1058	96	4	demonstrate	demonstrate	VERB
eurjchem-1058	96	5	the	the	DET
eurjchem-1058	96	6	linearity	linearity	NOUN
eurjchem-1058	96	7	of	of	ADP
eurjchem-1058	96	8	detector	detector	NOUN
eurjchem-1058	96	9	response	response	NOUN
eurjchem-1058	96	10	for	for	ADP
eurjchem-1058	96	11	pioglitazone	pioglitazone	NOUN
eurjchem-1058	96	12	hydrochloride	hydrochloride	NOUN
eurjchem-1058	96	13	and	and	CCONJ
eurjchem-1058	96	14	its	its	PRON
eurjchem-1058	96	15	impurities	impurity	NOUN
eurjchem-1058	96	16	,	,	PUNCT
eurjchem-1058	96	17	the	the	DET
eurjchem-1058	96	18	linearity	linearity	NOUN
eurjchem-1058	96	19	plot	plot	NOUN
eurjchem-1058	96	20	was	be	AUX
eurjchem-1058	96	21	drawn	draw	VERB
eurjchem-1058	96	22	taking	take	VERB
eurjchem-1058	96	23	the	the	DET
eurjchem-1058	96	24	concentration	concentration	NOUN
eurjchem-1058	96	25	on	on	ADP
eurjchem-1058	96	26	x	x	PUNCT
eurjchem-1058	96	27	axis	axis	NOUN
eurjchem-1058	96	28	and	and	CCONJ
eurjchem-1058	96	29	the	the	DET
eurjchem-1058	96	30	mean	mean	ADJ
eurjchem-1058	96	31	peak	peak	NOUN
eurjchem-1058	96	32	area	area	NOUN
eurjchem-1058	96	33	on	on	ADP
eurjchem-1058	96	34	y	y	PROPN
eurjchem-1058	96	35	axis	axis	NOUN
eurjchem-1058	96	36	.	.	PUNCT
eurjchem-1058	97	1	the	the	DET
eurjchem-1058	97	2	data	datum	NOUN
eurjchem-1058	97	3	was	be	AUX
eurjchem-1058	97	4	subjected	subject	VERB
eurjchem-1058	97	5	to	to	ADP
eurjchem-1058	97	6	statistical	statistical	ADJ
eurjchem-1058	97	7	analysis	analysis	NOUN
eurjchem-1058	97	8	using	use	VERB
eurjchem-1058	97	9	a	a	DET
eurjchem-1058	97	10	linear‐regression	linear‐regression	NOUN
eurjchem-1058	97	11	model	model	NOUN
eurjchem-1058	97	12	the	the	DET
eurjchem-1058	97	13	regression	regression	NOUN
eurjchem-1058	97	14	equations	equation	NOUN
eurjchem-1058	97	15	and	and	CCONJ
eurjchem-1058	97	16	correlation	correlation	NOUN
eurjchem-1058	97	17	coefficients	coefficient	NOUN
eurjchem-1058	97	18	(	(	PUNCT
eurjchem-1058	97	19	r2	r2	PROPN
eurjchem-1058	97	20	)	)	PUNCT
eurjchem-1058	97	21	are	be	AUX
eurjchem-1058	97	22	given	give	VERB
eurjchem-1058	97	23	in	in	ADP
eurjchem-1058	97	24	tables	table	NOUN
eurjchem-1058	97	25	2‐5	2‐5	NOUN
eurjchem-1058	97	26	.	.	PUNCT
eurjchem-1058	98	1	3.3.1	3.3.1	NUM
eurjchem-1058	98	2	.	.	NOUN
eurjchem-1058	98	3	acceptance	acceptance	NOUN
eurjchem-1058	98	4	criteria	criterion	NOUN
eurjchem-1058	98	5	the	the	DET
eurjchem-1058	98	6	correlation	correlation	NOUN
eurjchem-1058	98	7	coefficient	coefficient	NOUN
eurjchem-1058	98	8	should	should	AUX
eurjchem-1058	98	9	not	not	PART
eurjchem-1058	98	10	be	be	AUX
eurjchem-1058	98	11	less	less	ADJ
eurjchem-1058	98	12	than	than	ADP
eurjchem-1058	98	13	0.99	0.99	NUM
eurjchem-1058	98	14	.	.	PUNCT
eurjchem-1058	99	1	472	472	NUM
eurjchem-1058	99	2	prava	prava	NOUN
eurjchem-1058	99	3	and	and	CCONJ
eurjchem-1058	99	4	seru	seru	PROPN
eurjchem-1058	99	5	/	/	SYM
eurjchem-1058	99	6	european	european	PROPN
eurjchem-1058	99	7	journal	journal	PROPN
eurjchem-1058	99	8	of	of	ADP
eurjchem-1058	99	9	chemistry	chemistry	NOUN
eurjchem-1058	99	10	5	5	NUM
eurjchem-1058	99	11	(	(	PUNCT
eurjchem-1058	99	12	3	3	NUM
eurjchem-1058	99	13	)	)	PUNCT
eurjchem-1058	99	14	(	(	PUNCT
eurjchem-1058	99	15	2014	2014	NUM
eurjchem-1058	99	16	)	)	PUNCT
eurjchem-1058	99	17	469‐474	469‐474	PROPN
eurjchem-1058	99	18	table	table	NOUN
eurjchem-1058	99	19	3	3	NUM
eurjchem-1058	99	20	.	.	X
eurjchem-1058	99	21	linearity	linearity	NOUN
eurjchem-1058	99	22	for	for	ADP
eurjchem-1058	99	23	impurity‐b	impurity‐b	NOUN
eurjchem-1058	99	24	.	.	PUNCT
eurjchem-1058	100	1	sample	sample	VERB
eurjchem-1058	100	2	no	no	DET
eurjchem-1058	100	3	concentration	concentration	NOUN
eurjchem-1058	100	4	(	(	PUNCT
eurjchem-1058	100	5	µg	µg	NOUN
eurjchem-1058	100	6	/	/	SYM
eurjchem-1058	100	7	ml	ml	NOUN
eurjchem-1058	100	8	)	)	PUNCT
eurjchem-1058	100	9	peak	peak	NOUN
eurjchem-1058	100	10	area	area	NOUN
eurjchem-1058	100	11	mean	mean	VERB
eurjchem-1058	100	12	peak	peak	NOUN
eurjchem-1058	100	13	area	area	NOUN
eurjchem-1058	100	14	1	1	NUM
eurjchem-1058	100	15	0.376	0.376	NUM
eurjchem-1058	100	16	8213	8213	NUM
eurjchem-1058	100	17	8279	8279	NUM
eurjchem-1058	100	18	8201	8201	NUM
eurjchem-1058	100	19	8231	8231	NUM
eurjchem-1058	100	20	2	2	NUM
eurjchem-1058	100	21	0.751	0.751	NUM
eurjchem-1058	100	22	15503	15503	NUM
eurjchem-1058	100	23	15834	15834	NUM
eurjchem-1058	100	24	15743	15743	NUM
eurjchem-1058	100	25	15693.3	15693.3	NUM
eurjchem-1058	100	26	3	3	NUM
eurjchem-1058	100	27	1.127	1.127	NUM
eurjchem-1058	100	28	24698	24698	NUM
eurjchem-1058	100	29	24657	24657	NUM
eurjchem-1058	100	30	24651	24651	NUM
eurjchem-1058	100	31	24668.7	24668.7	NUM
eurjchem-1058	100	32	4	4	NUM
eurjchem-1058	100	33	1.502	1.502	NUM
eurjchem-1058	100	34	32541	32541	NUM
eurjchem-1058	100	35	32596	32596	NUM
eurjchem-1058	100	36	32775	32775	NUM
eurjchem-1058	100	37	32637.3	32637.3	NUM
eurjchem-1058	100	38	5	5	NUM
eurjchem-1058	100	39	1.878	1.878	NUM
eurjchem-1058	100	40	42168	42168	NUM
eurjchem-1058	100	41	42836	42836	NUM
eurjchem-1058	100	42	42619	42619	NUM
eurjchem-1058	100	43	42541.0	42541.0	NUM
eurjchem-1058	100	44	6	6	NUM
eurjchem-1058	100	45	2.253	2.253	NUM
eurjchem-1058	100	46	50172	50172	NUM
eurjchem-1058	100	47	50211	50211	NUM
eurjchem-1058	100	48	50056	50056	NUM
eurjchem-1058	100	49	50146.3	50146.3	NUM
eurjchem-1058	100	50	correlation	correlation	NOUN
eurjchem-1058	100	51	coefficient	coefficient	NOUN
eurjchem-1058	100	52	0.9988	0.9988	NUM
eurjchem-1058	100	53	slope	slope	NOUN
eurjchem-1058	100	54	22684	22684	NUM
eurjchem-1058	100	55	intercept	intercept	NOUN
eurjchem-1058	100	56	‐831.97	‐831.97	NOUN
eurjchem-1058	100	57	table	table	NOUN
eurjchem-1058	100	58	4	4	NUM
eurjchem-1058	100	59	.	.	PUNCT
eurjchem-1058	101	1	linearity	linearity	NOUN
eurjchem-1058	101	2	for	for	ADP
eurjchem-1058	101	3	impurity	impurity	NOUN
eurjchem-1058	101	4	c.	c.	NOUN
eurjchem-1058	101	5	sample	sample	NOUN
eurjchem-1058	101	6	no	no	DET
eurjchem-1058	101	7	concentration	concentration	NOUN
eurjchem-1058	101	8	(	(	PUNCT
eurjchem-1058	101	9	µg	µg	NOUN
eurjchem-1058	101	10	/	/	SYM
eurjchem-1058	101	11	ml	ml	NOUN
eurjchem-1058	101	12	)	)	PUNCT
eurjchem-1058	101	13	peak	peak	NOUN
eurjchem-1058	101	14	area	area	NOUN
eurjchem-1058	101	15	mean	mean	VERB
eurjchem-1058	101	16	peak	peak	NOUN
eurjchem-1058	101	17	area	area	NOUN
eurjchem-1058	101	18	1	1	NUM
eurjchem-1058	101	19	0.377	0.377	NUM
eurjchem-1058	101	20	5964	5964	NUM
eurjchem-1058	101	21	5980	5980	NUM
eurjchem-1058	101	22	5611	5611	NUM
eurjchem-1058	101	23	5851.67	5851.67	NUM
eurjchem-1058	101	24	2	2	NUM
eurjchem-1058	101	25	0.754	0.754	NUM
eurjchem-1058	101	26	10844	10844	NUM
eurjchem-1058	101	27	10983	10983	NUM
eurjchem-1058	101	28	11143	11143	NUM
eurjchem-1058	101	29	10990	10990	NUM
eurjchem-1058	101	30	3	3	NUM
eurjchem-1058	101	31	1.131	1.131	NUM
eurjchem-1058	101	32	17778	17778	NUM
eurjchem-1058	101	33	17680	17680	NUM
eurjchem-1058	101	34	17812	17812	NUM
eurjchem-1058	101	35	17756.7	17756.7	NUM
eurjchem-1058	101	36	4	4	NUM
eurjchem-1058	101	37	1.508	1.508	NUM
eurjchem-1058	101	38	23417	23417	NUM
eurjchem-1058	101	39	23398	23398	NUM
eurjchem-1058	101	40	23630	23630	NUM
eurjchem-1058	101	41	23481.7	23481.7	NUM
eurjchem-1058	101	42	5	5	NUM
eurjchem-1058	101	43	1.885	1.885	NUM
eurjchem-1058	101	44	29919	29919	NUM
eurjchem-1058	101	45	30352	30352	NUM
eurjchem-1058	101	46	30205	30205	NUM
eurjchem-1058	101	47	30158.7	30158.7	NUM
eurjchem-1058	101	48	6	6	NUM
eurjchem-1058	101	49	2.262	2.262	NUM
eurjchem-1058	101	50	35392	35392	NUM
eurjchem-1058	101	51	35575	35575	NUM
eurjchem-1058	101	52	35455	35455	NUM
eurjchem-1058	101	53	35474	35474	NUM
eurjchem-1058	101	54	correlation	correlation	NOUN
eurjchem-1058	101	55	coefficient	coefficient	NOUN
eurjchem-1058	101	56	0.9988	0.9988	NUM
eurjchem-1058	101	57	slope	slope	NOUN
eurjchem-1058	101	58	16017	16017	NUM
eurjchem-1058	101	59	intercept	intercept	NOUN
eurjchem-1058	101	60	‐515.48	‐515.48	NOUN
eurjchem-1058	101	61	table	table	NOUN
eurjchem-1058	101	62	5	5	NUM
eurjchem-1058	101	63	.	.	PUNCT
eurjchem-1058	102	1	linearity	linearity	NOUN
eurjchem-1058	102	2	for	for	ADP
eurjchem-1058	102	3	pioglitazone	pioglitazone	NOUN
eurjchem-1058	102	4	hydrochloride	hydrochloride	NOUN
eurjchem-1058	102	5	.	.	PUNCT
eurjchem-1058	103	1	sample	sample	VERB
eurjchem-1058	103	2	no	no	DET
eurjchem-1058	103	3	concentration	concentration	NOUN
eurjchem-1058	103	4	(	(	PUNCT
eurjchem-1058	103	5	µg	µg	NOUN
eurjchem-1058	103	6	/	/	SYM
eurjchem-1058	103	7	ml	ml	NOUN
eurjchem-1058	103	8	)	)	PUNCT
eurjchem-1058	103	9	peak	peak	NOUN
eurjchem-1058	103	10	area	area	NOUN
eurjchem-1058	103	11	mean	mean	VERB
eurjchem-1058	103	12	peak	peak	NOUN
eurjchem-1058	103	13	area	area	NOUN
eurjchem-1058	103	14	1	1	NUM
eurjchem-1058	103	15	0.376	0.376	NUM
eurjchem-1058	103	16	4351	4351	NUM
eurjchem-1058	103	17	3505	3505	NUM
eurjchem-1058	103	18	3965	3965	NUM
eurjchem-1058	103	19	3940.3	3940.3	NUM
eurjchem-1058	103	20	2	2	NUM
eurjchem-1058	103	21	0.751	0.751	NUM
eurjchem-1058	103	22	7298	7298	NUM
eurjchem-1058	103	23	7904	7904	NUM
eurjchem-1058	103	24	8666	8666	NUM
eurjchem-1058	103	25	7956	7956	NUM
eurjchem-1058	103	26	3	3	NUM
eurjchem-1058	103	27	1.127	1.127	NUM
eurjchem-1058	103	28	13099	13099	NUM
eurjchem-1058	103	29	12461	12461	NUM
eurjchem-1058	103	30	12883	12883	NUM
eurjchem-1058	103	31	12814.3	12814.3	NUM
eurjchem-1058	103	32	4	4	NUM
eurjchem-1058	103	33	1.502	1.502	NUM
eurjchem-1058	103	34	17290	17290	NUM
eurjchem-1058	103	35	16485	16485	NUM
eurjchem-1058	103	36	16587	16587	NUM
eurjchem-1058	103	37	16787.3	16787.3	NUM
eurjchem-1058	103	38	5	5	NUM
eurjchem-1058	103	39	1.878	1.878	NUM
eurjchem-1058	103	40	21674	21674	NUM
eurjchem-1058	103	41	24821	24821	NUM
eurjchem-1058	103	42	22442	22442	NUM
eurjchem-1058	103	43	22979	22979	NUM
eurjchem-1058	103	44	6	6	NUM
eurjchem-1058	103	45	2.253	2.253	NUM
eurjchem-1058	103	46	27411	27411	NUM
eurjchem-1058	103	47	28640	28640	NUM
eurjchem-1058	103	48	27112	27112	NUM
eurjchem-1058	103	49	27721	27721	NUM
eurjchem-1058	103	50	correlation	correlation	NOUN
eurjchem-1058	103	51	coefficient	coefficient	NOUN
eurjchem-1058	103	52	0.9959	0.9959	NUM
eurjchem-1058	103	53	slope	slope	NOUN
eurjchem-1058	103	54	12780	12780	NUM
eurjchem-1058	103	55	intercept	intercept	VERB
eurjchem-1058	103	56	‐1433.5	‐1433.5	NOUN
eurjchem-1058	103	57	3.4	3.4	NUM
eurjchem-1058	103	58	.	.	PUNCT
eurjchem-1058	104	1	accuracy	accuracy	NOUN
eurjchem-1058	104	2	and	and	CCONJ
eurjchem-1058	104	3	recovery	recovery	NOUN
eurjchem-1058	104	4	accuracy	accuracy	NOUN
eurjchem-1058	104	5	of	of	ADP
eurjchem-1058	104	6	the	the	DET
eurjchem-1058	104	7	test	test	NOUN
eurjchem-1058	104	8	method	method	NOUN
eurjchem-1058	104	9	was	be	AUX
eurjchem-1058	104	10	determined	determine	VERB
eurjchem-1058	104	11	by	by	ADP
eurjchem-1058	104	12	analysing	analyse	VERB
eurjchem-1058	104	13	pioglitazone	pioglitazone	NOUN
eurjchem-1058	104	14	hydrochloride	hydrochloride	NOUN
eurjchem-1058	104	15	drug	drug	NOUN
eurjchem-1058	104	16	substance	substance	NOUN
eurjchem-1058	104	17	spiked	spike	VERB
eurjchem-1058	104	18	with	with	ADP
eurjchem-1058	104	19	impurities	impurity	NOUN
eurjchem-1058	104	20	at	at	ADP
eurjchem-1058	104	21	three	three	NUM
eurjchem-1058	104	22	different	different	ADJ
eurjchem-1058	104	23	concentration	concentration	NOUN
eurjchem-1058	104	24	levels	level	NOUN
eurjchem-1058	104	25	of	of	ADP
eurjchem-1058	104	26	50	50	NUM
eurjchem-1058	104	27	%	%	NOUN
eurjchem-1058	104	28	,	,	PUNCT
eurjchem-1058	104	29	100	100	NUM
eurjchem-1058	104	30	%	%	NOUN
eurjchem-1058	104	31	,	,	PUNCT
eurjchem-1058	104	32	and	and	CCONJ
eurjchem-1058	104	33	150	150	NUM
eurjchem-1058	104	34	%	%	NOUN
eurjchem-1058	104	35	of	of	ADP
eurjchem-1058	104	36	each	each	PRON
eurjchem-1058	104	37	in	in	ADP
eurjchem-1058	104	38	triplicate	triplicate	NOUN
eurjchem-1058	104	39	at	at	ADP
eurjchem-1058	104	40	the	the	DET
eurjchem-1058	104	41	specified	specify	VERB
eurjchem-1058	104	42	limit	limit	NOUN
eurjchem-1058	104	43	.	.	PUNCT
eurjchem-1058	105	1	the	the	DET
eurjchem-1058	105	2	mean	mean	ADJ
eurjchem-1058	105	3	recoveries	recovery	NOUN
eurjchem-1058	105	4	of	of	ADP
eurjchem-1058	105	5	all	all	DET
eurjchem-1058	105	6	the	the	DET
eurjchem-1058	105	7	impurities	impurity	NOUN
eurjchem-1058	105	8	were	be	AUX
eurjchem-1058	105	9	calculated	calculate	VERB
eurjchem-1058	105	10	(	(	PUNCT
eurjchem-1058	105	11	table	table	NOUN
eurjchem-1058	105	12	6	6	NUM
eurjchem-1058	105	13	)	)	PUNCT
eurjchem-1058	105	14	.	.	PUNCT
eurjchem-1058	106	1	the	the	DET
eurjchem-1058	106	2	%	%	NOUN
eurjchem-1058	106	3	recovery	recovery	NOUN
eurjchem-1058	106	4	obtained	obtain	VERB
eurjchem-1058	106	5	is	be	AUX
eurjchem-1058	106	6	well	well	ADV
eurjchem-1058	106	7	within	within	ADP
eurjchem-1058	106	8	the	the	DET
eurjchem-1058	106	9	limit	limit	NOUN
eurjchem-1058	106	10	of	of	ADP
eurjchem-1058	106	11	85‐115	85‐115	NUM
eurjchem-1058	106	12	%	%	NOUN
eurjchem-1058	106	13	.	.	PUNCT
eurjchem-1058	107	1	this	this	PRON
eurjchem-1058	107	2	indicated	indicate	VERB
eurjchem-1058	107	3	that	that	SCONJ
eurjchem-1058	107	4	the	the	DET
eurjchem-1058	107	5	method	method	NOUN
eurjchem-1058	107	6	is	be	AUX
eurjchem-1058	107	7	accurate	accurate	ADJ
eurjchem-1058	107	8	to	to	PART
eurjchem-1058	107	9	determine	determine	VERB
eurjchem-1058	107	10	the	the	DET
eurjchem-1058	107	11	process	process	NOUN
eurjchem-1058	107	12	impurities	impurity	NOUN
eurjchem-1058	107	13	in	in	ADP
eurjchem-1058	107	14	pioglitazone	pioglitazone	NOUN
eurjchem-1058	107	15	hydrochloride	hydrochloride	NOUN
eurjchem-1058	107	16	.	.	PUNCT
eurjchem-1058	108	1	3.4.1	3.4.1	X
eurjchem-1058	108	2	.	.	X
eurjchem-1058	108	3	acceptance	acceptance	NOUN
eurjchem-1058	108	4	criteria	criterion	NOUN
eurjchem-1058	108	5	the	the	DET
eurjchem-1058	108	6	mean	mean	ADJ
eurjchem-1058	108	7	percent	percent	NOUN
eurjchem-1058	108	8	recovery	recovery	NOUN
eurjchem-1058	108	9	of	of	ADP
eurjchem-1058	108	10	the	the	DET
eurjchem-1058	108	11	impurities	impurity	NOUN
eurjchem-1058	108	12	at	at	ADP
eurjchem-1058	108	13	each	each	DET
eurjchem-1058	108	14	level	level	NOUN
eurjchem-1058	108	15	should	should	AUX
eurjchem-1058	108	16	be	be	AUX
eurjchem-1058	108	17	not	not	PART
eurjchem-1058	108	18	less	less	ADJ
eurjchem-1058	108	19	than	than	ADP
eurjchem-1058	108	20	85.0	85.0	NUM
eurjchem-1058	108	21	%	%	NOUN
eurjchem-1058	108	22	and	and	CCONJ
eurjchem-1058	108	23	not	not	PART
eurjchem-1058	108	24	more	more	ADJ
eurjchem-1058	108	25	than	than	ADP
eurjchem-1058	108	26	115.0	115.0	NUM
eurjchem-1058	108	27	%	%	NOUN
eurjchem-1058	108	28	.	.	PUNCT
eurjchem-1058	109	1	prava	prava	PROPN
eurjchem-1058	109	2	and	and	CCONJ
eurjchem-1058	109	3	seru	seru	PROPN
eurjchem-1058	109	4	/	/	SYM
eurjchem-1058	109	5	european	european	PROPN
eurjchem-1058	109	6	journal	journal	PROPN
eurjchem-1058	109	7	of	of	ADP
eurjchem-1058	109	8	chemistry	chemistry	NOUN
eurjchem-1058	109	9	5	5	NUM
eurjchem-1058	109	10	(	(	PUNCT
eurjchem-1058	109	11	3	3	NUM
eurjchem-1058	109	12	)	)	PUNCT
eurjchem-1058	109	13	(	(	PUNCT
eurjchem-1058	109	14	2014	2014	NUM
eurjchem-1058	109	15	)	)	PUNCT
eurjchem-1058	109	16	469‐474	469‐474	NOUN
eurjchem-1058	109	17	473	473	NUM
eurjchem-1058	109	18	table	table	NOUN
eurjchem-1058	109	19	6	6	NUM
eurjchem-1058	109	20	.	.	PUNCT
eurjchem-1058	110	1	recovery	recovery	NOUN
eurjchem-1058	110	2	studies	study	NOUN
eurjchem-1058	110	3	for	for	ADP
eurjchem-1058	110	4	impurities	impurity	NOUN
eurjchem-1058	110	5	of	of	ADP
eurjchem-1058	110	6	pioglitazone	pioglitazone	NOUN
eurjchem-1058	110	7	hydrochloride	hydrochloride	NOUN
eurjchem-1058	110	8	.	.	PUNCT
eurjchem-1058	111	1	name	name	NOUN
eurjchem-1058	111	2	spike	spike	ADJ
eurjchem-1058	111	3	level	level	NOUN
eurjchem-1058	111	4	(	(	PUNCT
eurjchem-1058	111	5	%	%	INTJ
eurjchem-1058	111	6	)	)	PUNCT
eurjchem-1058	111	7	concentration	concentration	NOUN
eurjchem-1058	111	8	spiked	spike	VERB
eurjchem-1058	111	9	(	(	PUNCT
eurjchem-1058	111	10	μg	μg	PROPN
eurjchem-1058	111	11	/	/	SYM
eurjchem-1058	111	12	ml	ml	NOUN
eurjchem-1058	111	13	)	)	PUNCT
eurjchem-1058	111	14	concentration	concentration	NOUN
eurjchem-1058	111	15	recovered	recover	VERB
eurjchem-1058	111	16	(	(	PUNCT
eurjchem-1058	111	17	μg	μg	NOUN
eurjchem-1058	111	18	/	/	SYM
eurjchem-1058	111	19	ml	ml	NOUN
eurjchem-1058	111	20	)	)	PUNCT
eurjchem-1058	111	21	%	%	NOUN
eurjchem-1058	111	22	recovery	recovery	NOUN
eurjchem-1058	112	1	a	a	DET
eurjchem-1058	112	2	impurity‐a	impurity‐a	VERB
eurjchem-1058	112	3	50	50	NUM
eurjchem-1058	112	4	0.76	0.76	NUM
eurjchem-1058	112	5	0.83	0.83	NUM
eurjchem-1058	112	6	109.2	109.2	NUM
eurjchem-1058	112	7	100	100	NUM
eurjchem-1058	112	8	1.52	1.52	NUM
eurjchem-1058	112	9	1.64	1.64	NUM
eurjchem-1058	112	10	107.9	107.9	NUM
eurjchem-1058	112	11	150	150	NUM
eurjchem-1058	112	12	2.28	2.28	NUM
eurjchem-1058	112	13	2.49	2.49	NUM
eurjchem-1058	112	14	109.2	109.2	NUM
eurjchem-1058	112	15	impurity‐b	impurity‐b	NOUN
eurjchem-1058	112	16	50	50	NUM
eurjchem-1058	112	17	0.75	0.75	NUM
eurjchem-1058	112	18	0.72	0.72	NUM
eurjchem-1058	112	19	96.0	96.0	NUM
eurjchem-1058	112	20	100	100	NUM
eurjchem-1058	112	21	1.50	1.50	NUM
eurjchem-1058	112	22	1.42	1.42	NUM
eurjchem-1058	112	23	94.7	94.7	NUM
eurjchem-1058	112	24	150	150	NUM
eurjchem-1058	112	25	2.25	2.25	NUM
eurjchem-1058	112	26	2.13	2.13	NUM
eurjchem-1058	112	27	94.7	94.7	NUM
eurjchem-1058	112	28	impurity‐c	impurity‐c	NOUN
eurjchem-1058	112	29	50	50	NUM
eurjchem-1058	112	30	0.78	0.78	NUM
eurjchem-1058	112	31	0.88	0.88	NUM
eurjchem-1058	112	32	112.8	112.8	NUM
eurjchem-1058	112	33	100	100	NUM
eurjchem-1058	112	34	1.56	1.56	NUM
eurjchem-1058	112	35	1.68	1.68	NUM
eurjchem-1058	112	36	107.7	107.7	NUM
eurjchem-1058	112	37	150	150	NUM
eurjchem-1058	112	38	2.34	2.34	NUM
eurjchem-1058	112	39	2.50	2.50	NUM
eurjchem-1058	112	40	106.8	106.8	NUM
eurjchem-1058	112	41	a	a	DET
eurjchem-1058	112	42	average	average	NOUN
eurjchem-1058	112	43	of	of	ADP
eurjchem-1058	112	44	three	three	NUM
eurjchem-1058	112	45	determinations	determination	NOUN
eurjchem-1058	112	46	.	.	PUNCT
eurjchem-1058	113	1	table	table	NOUN
eurjchem-1058	113	2	7	7	NUM
eurjchem-1058	113	3	.	.	PUNCT
eurjchem-1058	113	4	precision	precision	NOUN
eurjchem-1058	113	5	studies	study	NOUN
eurjchem-1058	113	6	for	for	ADP
eurjchem-1058	113	7	pioglitazone	pioglitazone	NOUN
eurjchem-1058	113	8	hydrochloride	hydrochloride	NOUN
eurjchem-1058	113	9	and	and	CCONJ
eurjchem-1058	113	10	its	its	PRON
eurjchem-1058	113	11	impurities	impurity	NOUN
eurjchem-1058	113	12	.	.	PUNCT
eurjchem-1058	114	1	name	name	NOUN
eurjchem-1058	114	2	method	method	NOUN
eurjchem-1058	114	3	precision	precision	NOUN
eurjchem-1058	114	4	%	%	NOUN
eurjchem-1058	114	5	r.s.d	r.s.d	ADJ
eurjchem-1058	114	6	(	(	PUNCT
eurjchem-1058	114	7	n=6	n=6	NOUN
eurjchem-1058	114	8	)	)	PUNCT
eurjchem-1058	114	9	intermediate	intermediate	ADJ
eurjchem-1058	114	10	precision	precision	NOUN
eurjchem-1058	114	11	intraday	intraday	PROPN
eurjchem-1058	114	12	%	%	INTJ
eurjchem-1058	114	13	rsd	rsd	PROPN
eurjchem-1058	114	14	(	(	PUNCT
eurjchem-1058	114	15	n=6	n=6	NOUN
eurjchem-1058	114	16	)	)	PUNCT
eurjchem-1058	114	17	interday	interday	NOUN
eurjchem-1058	114	18	%	%	PROPN
eurjchem-1058	114	19	rsd	rsd	PROPN
eurjchem-1058	114	20	(	(	PUNCT
eurjchem-1058	114	21	n=6	n=6	NOUN
eurjchem-1058	114	22	)	)	PUNCT
eurjchem-1058	114	23	impurity‐a	impurity‐a	VERB
eurjchem-1058	114	24	0.58	0.58	NUM
eurjchem-1058	114	25	0.53±0.09	0.53±0.09	NOUN
eurjchem-1058	114	26	0.51±0.06	0.51±0.06	PROPN
eurjchem-1058	114	27	impurity‐b	impurity‐b	NOUN
eurjchem-1058	114	28	0.61	0.61	NUM
eurjchem-1058	114	29	0.63±0.05	0.63±0.05	NOUN
eurjchem-1058	114	30	0.65±0.09	0.65±0.09	PROPN
eurjchem-1058	115	1	impurity‐c	impurity‐c	PROPN
eurjchem-1058	115	2	0.88	0.88	NUM
eurjchem-1058	115	3	0.86±0.07	0.86±0.07	NOUN
eurjchem-1058	115	4	0.91±0.09	0.91±0.09	NOUN
eurjchem-1058	115	5	pioglitazone	pioglitazone	NOUN
eurjchem-1058	115	6	hydrochloride	hydrochloride	NOUN
eurjchem-1058	116	1	0.36	0.36	NUM
eurjchem-1058	116	2	0.39±0.09	0.39±0.09	NUM
eurjchem-1058	116	3	0.42±0.07	0.42±0.07	NUM
eurjchem-1058	116	4	table	table	NOUN
eurjchem-1058	116	5	8	8	NUM
eurjchem-1058	116	6	.	.	PUNCT
eurjchem-1058	116	7	results	result	NOUN
eurjchem-1058	116	8	for	for	ADP
eurjchem-1058	116	9	limit	limit	NOUN
eurjchem-1058	116	10	of	of	ADP
eurjchem-1058	116	11	quantitation	quantitation	NOUN
eurjchem-1058	116	12	.	.	PUNCT
eurjchem-1058	117	1	s.	s.	PROPN
eurjchem-1058	118	1	no	no	DET
eurjchem-1058	118	2	name	name	NOUN
eurjchem-1058	118	3	concentration	concentration	NOUN
eurjchem-1058	118	4	(	(	PUNCT
eurjchem-1058	118	5	µg	µg	NOUN
eurjchem-1058	118	6	/	/	SYM
eurjchem-1058	118	7	ml	ml	NOUN
eurjchem-1058	118	8	)	)	PUNCT
eurjchem-1058	118	9	observed	observed	ADJ
eurjchem-1058	118	10	signal	signal	NOUN
eurjchem-1058	118	11	to	to	PART
eurjchem-1058	118	12	noise	noise	VERB
eurjchem-1058	118	13	ratio	ratio	NOUN
eurjchem-1058	118	14	1	1	NUM
eurjchem-1058	118	15	impurity‐a	impurity‐a	VERB
eurjchem-1058	118	16	0.187	0.187	NUM
eurjchem-1058	118	17	9.9	9.9	NUM
eurjchem-1058	118	18	2	2	NUM
eurjchem-1058	118	19	impurity‐b	impurity‐b	NOUN
eurjchem-1058	118	20	0.376	0.376	NUM
eurjchem-1058	118	21	10.2	10.2	NUM
eurjchem-1058	118	22	3	3	NUM
eurjchem-1058	118	23	impurity‐c	impurity‐c	VERB
eurjchem-1058	118	24	0.377	0.377	NUM
eurjchem-1058	118	25	10.4	10.4	NUM
eurjchem-1058	118	26	4	4	NUM
eurjchem-1058	118	27	pioglitazone	pioglitazone	NOUN
eurjchem-1058	118	28	hydrochloride	hydrochloride	NOUN
eurjchem-1058	118	29	0.751	0.751	NUM
eurjchem-1058	118	30	9.8	9.8	NUM
eurjchem-1058	118	31	table	table	NOUN
eurjchem-1058	118	32	9	9	NUM
eurjchem-1058	118	33	.	.	PUNCT
eurjchem-1058	118	34	results	result	NOUN
eurjchem-1058	118	35	for	for	ADP
eurjchem-1058	118	36	limit	limit	NOUN
eurjchem-1058	118	37	of	of	ADP
eurjchem-1058	118	38	detection	detection	NOUN
eurjchem-1058	118	39	.	.	PUNCT
eurjchem-1058	119	1	s.	s.	PROPN
eurjchem-1058	120	1	no	no	DET
eurjchem-1058	120	2	name	name	NOUN
eurjchem-1058	120	3	concentration	concentration	NOUN
eurjchem-1058	120	4	(	(	PUNCT
eurjchem-1058	120	5	µg	µg	NOUN
eurjchem-1058	120	6	/	/	SYM
eurjchem-1058	120	7	ml	ml	NOUN
eurjchem-1058	120	8	)	)	PUNCT
eurjchem-1058	120	9	observed	observed	ADJ
eurjchem-1058	120	10	signal	signal	NOUN
eurjchem-1058	120	11	to	to	PART
eurjchem-1058	120	12	noise	noise	VERB
eurjchem-1058	120	13	ratio	ratio	NOUN
eurjchem-1058	120	14	1	1	NUM
eurjchem-1058	120	15	impurity‐a	impurity‐a	VERB
eurjchem-1058	120	16	0.061	0.061	NUM
eurjchem-1058	120	17	2.9	2.9	NUM
eurjchem-1058	120	18	2	2	NUM
eurjchem-1058	120	19	impurity‐b	impurity‐b	NOUN
eurjchem-1058	120	20	0.124	0.124	NUM
eurjchem-1058	120	21	3.1	3.1	NUM
eurjchem-1058	120	22	3	3	NUM
eurjchem-1058	120	23	impurity‐c	impurity‐c	NOUN
eurjchem-1058	120	24	0.124	0.124	NUM
eurjchem-1058	120	25	3.4	3.4	NUM
eurjchem-1058	120	26	4	4	NUM
eurjchem-1058	120	27	pioglitazone	pioglitazone	NOUN
eurjchem-1058	120	28	hydrochloride	hydrochloride	NOUN
eurjchem-1058	120	29	0.250	0.250	NUM
eurjchem-1058	120	30	2.8	2.8	NUM
eurjchem-1058	120	31	3.5	3.5	NUM
eurjchem-1058	120	32	.	.	PUNCT
eurjchem-1058	121	1	precision	precision	NOUN
eurjchem-1058	121	2	system	system	NOUN
eurjchem-1058	121	3	precision	precision	NOUN
eurjchem-1058	121	4	of	of	ADP
eurjchem-1058	121	5	the	the	DET
eurjchem-1058	121	6	method	method	NOUN
eurjchem-1058	121	7	was	be	AUX
eurjchem-1058	121	8	evaluated	evaluate	VERB
eurjchem-1058	121	9	by	by	ADP
eurjchem-1058	121	10	injecting	inject	VERB
eurjchem-1058	121	11	the	the	DET
eurjchem-1058	121	12	standard	standard	ADJ
eurjchem-1058	121	13	solution	solution	NOUN
eurjchem-1058	121	14	six	six	NUM
eurjchem-1058	121	15	times	time	NOUN
eurjchem-1058	121	16	and	and	CCONJ
eurjchem-1058	121	17	percent	percent	NOUN
eurjchem-1058	121	18	relative	relative	ADJ
eurjchem-1058	121	19	standard	standard	ADJ
eurjchem-1058	121	20	deviation	deviation	NOUN
eurjchem-1058	121	21	(	(	PUNCT
eurjchem-1058	121	22	%	%	INTJ
eurjchem-1058	121	23	r.s.d	r.s.d	NOUN
eurjchem-1058	121	24	)	)	PUNCT
eurjchem-1058	121	25	for	for	ADP
eurjchem-1058	121	26	area	area	NOUN
eurjchem-1058	121	27	of	of	ADP
eurjchem-1058	121	28	pioglitazone	pioglitazone	NOUN
eurjchem-1058	121	29	hydrochloride	hydrochloride	NOUN
eurjchem-1058	121	30	peak	peak	NOUN
eurjchem-1058	121	31	was	be	AUX
eurjchem-1058	121	32	calculated	calculate	VERB
eurjchem-1058	121	33	.	.	PUNCT
eurjchem-1058	122	1	it	it	PRON
eurjchem-1058	122	2	was	be	AUX
eurjchem-1058	122	3	found	find	VERB
eurjchem-1058	122	4	to	to	PART
eurjchem-1058	122	5	be	be	AUX
eurjchem-1058	122	6	less	less	ADJ
eurjchem-1058	122	7	than	than	ADP
eurjchem-1058	122	8	2.0	2.0	NUM
eurjchem-1058	122	9	%	%	NOUN
eurjchem-1058	122	10	(	(	PUNCT
eurjchem-1058	122	11	r.s.d	r.s.d	NOUN
eurjchem-1058	122	12	)	)	PUNCT
eurjchem-1058	122	13	.	.	PUNCT
eurjchem-1058	123	1	the	the	DET
eurjchem-1058	123	2	precision	precision	NOUN
eurjchem-1058	123	3	of	of	ADP
eurjchem-1058	123	4	the	the	DET
eurjchem-1058	123	5	method	method	NOUN
eurjchem-1058	123	6	for	for	ADP
eurjchem-1058	123	7	the	the	DET
eurjchem-1058	123	8	determination	determination	NOUN
eurjchem-1058	123	9	of	of	ADP
eurjchem-1058	123	10	impurities	impurity	NOUN
eurjchem-1058	123	11	related	relate	VERB
eurjchem-1058	123	12	to	to	ADP
eurjchem-1058	123	13	pioglitazone	pioglitazone	NOUN
eurjchem-1058	123	14	hydrochloride	hydrochloride	NOUN
eurjchem-1058	123	15	was	be	AUX
eurjchem-1058	123	16	studied	study	VERB
eurjchem-1058	123	17	for	for	ADP
eurjchem-1058	123	18	repeatability	repeatability	NOUN
eurjchem-1058	123	19	and	and	CCONJ
eurjchem-1058	123	20	intermediate	intermediate	ADJ
eurjchem-1058	123	21	precision	precision	NOUN
eurjchem-1058	123	22	at	at	ADP
eurjchem-1058	123	23	100	100	NUM
eurjchem-1058	123	24	%	%	NOUN
eurjchem-1058	123	25	level	level	NOUN
eurjchem-1058	123	26	.	.	PUNCT
eurjchem-1058	124	1	repeatability	repeatability	NOUN
eurjchem-1058	124	2	was	be	AUX
eurjchem-1058	124	3	demonstrated	demonstrate	VERB
eurjchem-1058	124	4	by	by	ADP
eurjchem-1058	124	5	analysing	analyse	VERB
eurjchem-1058	124	6	the	the	DET
eurjchem-1058	124	7	standard	standard	ADJ
eurjchem-1058	124	8	solution	solution	NOUN
eurjchem-1058	124	9	spiked	spike	VERB
eurjchem-1058	124	10	with	with	ADP
eurjchem-1058	124	11	impurities	impurity	NOUN
eurjchem-1058	124	12	for	for	ADP
eurjchem-1058	124	13	six	six	NUM
eurjchem-1058	124	14	times	time	NOUN
eurjchem-1058	124	15	.	.	PUNCT
eurjchem-1058	125	1	the	the	DET
eurjchem-1058	125	2	%	%	NOUN
eurjchem-1058	125	3	r.s.d	r.s.d	NOUN
eurjchem-1058	125	4	for	for	ADP
eurjchem-1058	125	5	peak	peak	NOUN
eurjchem-1058	125	6	area	area	NOUN
eurjchem-1058	125	7	of	of	ADP
eurjchem-1058	125	8	each	each	DET
eurjchem-1058	125	9	impurity	impurity	NOUN
eurjchem-1058	125	10	was	be	AUX
eurjchem-1058	125	11	calculated	calculate	VERB
eurjchem-1058	125	12	.	.	PUNCT
eurjchem-1058	126	1	intermediate	intermediate	ADJ
eurjchem-1058	126	2	precision	precision	NOUN
eurjchem-1058	126	3	was	be	AUX
eurjchem-1058	126	4	demonstrated	demonstrate	VERB
eurjchem-1058	126	5	by	by	ADP
eurjchem-1058	126	6	analysing	analyse	VERB
eurjchem-1058	126	7	same	same	ADJ
eurjchem-1058	126	8	sample	sample	NOUN
eurjchem-1058	126	9	of	of	ADP
eurjchem-1058	126	10	pioglitazone	pioglitazone	NOUN
eurjchem-1058	126	11	hydrochloride	hydrochloride	NOUN
eurjchem-1058	126	12	by	by	ADP
eurjchem-1058	126	13	two	two	NUM
eurjchem-1058	126	14	different	different	ADJ
eurjchem-1058	126	15	analysts	analyst	NOUN
eurjchem-1058	126	16	on	on	ADP
eurjchem-1058	126	17	two	two	NUM
eurjchem-1058	126	18	different	different	ADJ
eurjchem-1058	126	19	days	day	NOUN
eurjchem-1058	126	20	(	(	PUNCT
eurjchem-1058	126	21	inter‐day	inter‐day	NOUN
eurjchem-1058	126	22	)	)	PUNCT
eurjchem-1058	126	23	.	.	PUNCT
eurjchem-1058	127	1	intra‐day	intra‐day	NOUN
eurjchem-1058	127	2	variations	variation	NOUN
eurjchem-1058	127	3	of	of	ADP
eurjchem-1058	127	4	impurities	impurity	NOUN
eurjchem-1058	127	5	related	relate	VERB
eurjchem-1058	127	6	to	to	ADP
eurjchem-1058	127	7	pioglitazone	pioglitazone	NOUN
eurjchem-1058	127	8	hydrochloride	hydrochloride	NOUN
eurjchem-1058	127	9	are	be	AUX
eurjchem-1058	127	10	expressed	express	VERB
eurjchem-1058	127	11	in	in	ADP
eurjchem-1058	127	12	terms	term	NOUN
eurjchem-1058	127	13	of	of	ADP
eurjchem-1058	127	14	%	%	NOUN
eurjchem-1058	127	15	r.s.d	r.s.d	ADJ
eurjchem-1058	127	16	values	value	NOUN
eurjchem-1058	127	17	.	.	PUNCT
eurjchem-1058	128	1	repeatability	repeatability	NOUN
eurjchem-1058	128	2	and	and	CCONJ
eurjchem-1058	128	3	intermediate	intermediate	ADJ
eurjchem-1058	128	4	precision	precision	NOUN
eurjchem-1058	128	5	for	for	ADP
eurjchem-1058	128	6	the	the	DET
eurjchem-1058	128	7	process‐related	process‐related	ADJ
eurjchem-1058	128	8	impurities	impurity	NOUN
eurjchem-1058	128	9	in	in	ADP
eurjchem-1058	128	10	pioglitazone	pioglitazone	NOUN
eurjchem-1058	128	11	hydrochloride	hydrochloride	NOUN
eurjchem-1058	128	12	were	be	AUX
eurjchem-1058	128	13	found	find	VERB
eurjchem-1058	128	14	to	to	PART
eurjchem-1058	128	15	be	be	AUX
eurjchem-1058	128	16	less	less	ADJ
eurjchem-1058	128	17	than	than	ADP
eurjchem-1058	128	18	1.0	1.0	NUM
eurjchem-1058	128	19	%	%	NOUN
eurjchem-1058	128	20	r.s.d	r.s.d	NOUN
eurjchem-1058	128	21	.	.	PUNCT
eurjchem-1058	129	1	the	the	DET
eurjchem-1058	129	2	results	result	NOUN
eurjchem-1058	129	3	are	be	AUX
eurjchem-1058	129	4	given	give	VERB
eurjchem-1058	129	5	in	in	ADP
eurjchem-1058	129	6	table	table	NOUN
eurjchem-1058	129	7	7	7	NUM
eurjchem-1058	129	8	,	,	PUNCT
eurjchem-1058	129	9	which	which	PRON
eurjchem-1058	129	10	confirmed	confirm	VERB
eurjchem-1058	129	11	good	good	ADJ
eurjchem-1058	129	12	precision	precision	NOUN
eurjchem-1058	129	13	of	of	ADP
eurjchem-1058	129	14	the	the	DET
eurjchem-1058	129	15	method	method	NOUN
eurjchem-1058	129	16	.	.	PUNCT
eurjchem-1058	130	1	3.6	3.6	NUM
eurjchem-1058	130	2	.	.	PUNCT
eurjchem-1058	130	3	limit	limit	NOUN
eurjchem-1058	130	4	of	of	ADP
eurjchem-1058	130	5	detection	detection	NOUN
eurjchem-1058	130	6	(	(	PUNCT
eurjchem-1058	130	7	lod	lod	PROPN
eurjchem-1058	130	8	)	)	PUNCT
eurjchem-1058	130	9	and	and	CCONJ
eurjchem-1058	130	10	limit	limit	NOUN
eurjchem-1058	130	11	of	of	ADP
eurjchem-1058	130	12	quantitation	quantitation	NOUN
eurjchem-1058	130	13	(	(	PUNCT
eurjchem-1058	130	14	loq	loq	PROPN
eurjchem-1058	130	15	)	)	PUNCT
eurjchem-1058	130	16	the	the	DET
eurjchem-1058	130	17	limit	limit	NOUN
eurjchem-1058	130	18	of	of	ADP
eurjchem-1058	130	19	detection	detection	NOUN
eurjchem-1058	130	20	(	(	PUNCT
eurjchem-1058	130	21	lod	lod	PROPN
eurjchem-1058	130	22	)	)	PUNCT
eurjchem-1058	130	23	and	and	CCONJ
eurjchem-1058	130	24	limit	limit	NOUN
eurjchem-1058	130	25	of	of	ADP
eurjchem-1058	130	26	quantification	quantification	NOUN
eurjchem-1058	130	27	(	(	PUNCT
eurjchem-1058	130	28	loq	loq	PROPN
eurjchem-1058	130	29	)	)	PUNCT
eurjchem-1058	130	30	represent	represent	VERB
eurjchem-1058	130	31	the	the	DET
eurjchem-1058	130	32	concentration	concentration	NOUN
eurjchem-1058	130	33	of	of	ADP
eurjchem-1058	130	34	the	the	DET
eurjchem-1058	130	35	analyte	analyte	NOUN
eurjchem-1058	130	36	that	that	PRON
eurjchem-1058	130	37	would	would	AUX
eurjchem-1058	130	38	yield	yield	VERB
eurjchem-1058	130	39	signal‐to‐noise	signal‐to‐noise	NOUN
eurjchem-1058	130	40	ratios	ratio	NOUN
eurjchem-1058	130	41	of	of	ADP
eurjchem-1058	130	42	3	3	NUM
eurjchem-1058	130	43	for	for	ADP
eurjchem-1058	130	44	lod	lod	PROPN
eurjchem-1058	130	45	and	and	CCONJ
eurjchem-1058	130	46	10	10	NUM
eurjchem-1058	130	47	for	for	ADP
eurjchem-1058	130	48	loq	loq	PROPN
eurjchem-1058	130	49	,	,	PUNCT
eurjchem-1058	130	50	respectively	respectively	ADV
eurjchem-1058	130	51	.	.	PUNCT
eurjchem-1058	131	1	lod	lod	PROPN
eurjchem-1058	131	2	and	and	CCONJ
eurjchem-1058	131	3	loq	loq	PROPN
eurjchem-1058	131	4	were	be	AUX
eurjchem-1058	131	5	determined	determine	VERB
eurjchem-1058	131	6	by	by	ADP
eurjchem-1058	131	7	measuring	measure	VERB
eurjchem-1058	131	8	the	the	DET
eurjchem-1058	131	9	magnitude	magnitude	NOUN
eurjchem-1058	131	10	of	of	ADP
eurjchem-1058	131	11	analytical	analytical	ADJ
eurjchem-1058	131	12	background	background	NOUN
eurjchem-1058	131	13	by	by	ADP
eurjchem-1058	131	14	blank	blank	ADJ
eurjchem-1058	131	15	samples	sample	NOUN
eurjchem-1058	131	16	and	and	CCONJ
eurjchem-1058	131	17	calculating	calculate	VERB
eurjchem-1058	131	18	the	the	DET
eurjchem-1058	131	19	signal‐to‐noise	signal‐to‐noise	NOUN
eurjchem-1058	131	20	ratio	ratio	NOUN
eurjchem-1058	131	21	for	for	ADP
eurjchem-1058	131	22	each	each	DET
eurjchem-1058	131	23	compound	compound	NOUN
eurjchem-1058	131	24	by	by	ADP
eurjchem-1058	131	25	injecting	inject	VERB
eurjchem-1058	131	26	a	a	DET
eurjchem-1058	131	27	series	series	NOUN
eurjchem-1058	131	28	of	of	ADP
eurjchem-1058	131	29	solutions	solution	NOUN
eurjchem-1058	131	30	until	until	ADP
eurjchem-1058	131	31	s	s	NOUN
eurjchem-1058	131	32	/	/	SYM
eurjchem-1058	131	33	n	n	NOUN
eurjchem-1058	131	34	ratio	ratio	NOUN
eurjchem-1058	131	35	3	3	NUM
eurjchem-1058	131	36	for	for	ADP
eurjchem-1058	131	37	lod	lod	PROPN
eurjchem-1058	131	38	and	and	CCONJ
eurjchem-1058	131	39	10	10	NUM
eurjchem-1058	131	40	for	for	ADP
eurjchem-1058	131	41	loq	loq	PROPN
eurjchem-1058	131	42	.	.	PUNCT
eurjchem-1058	132	1	loq	loq	PROPN
eurjchem-1058	132	2	and	and	CCONJ
eurjchem-1058	132	3	lod	lod	PROPN
eurjchem-1058	132	4	values	value	NOUN
eurjchem-1058	132	5	are	be	AUX
eurjchem-1058	132	6	given	give	VERB
eurjchem-1058	132	7	in	in	ADP
eurjchem-1058	132	8	table	table	NOUN
eurjchem-1058	132	9	8	8	NUM
eurjchem-1058	132	10	and	and	CCONJ
eurjchem-1058	132	11	9	9	NUM
eurjchem-1058	132	12	and	and	CCONJ
eurjchem-1058	132	13	its	its	PRON
eurjchem-1058	132	14	chromatograms	chromatogram	NOUN
eurjchem-1058	132	15	were	be	AUX
eurjchem-1058	132	16	shown	show	VERB
eurjchem-1058	132	17	in	in	ADP
eurjchem-1058	132	18	figures	figure	NOUN
eurjchem-1058	132	19	2	2	NUM
eurjchem-1058	132	20	and	and	CCONJ
eurjchem-1058	132	21	3	3	NUM
eurjchem-1058	132	22	.	.	NOUN
eurjchem-1058	132	23	3.7	3.7	NUM
eurjchem-1058	132	24	.	.	PUNCT
eurjchem-1058	133	1	robustness	robustness	NOUN
eurjchem-1058	133	2	to	to	PART
eurjchem-1058	133	3	determine	determine	VERB
eurjchem-1058	133	4	the	the	DET
eurjchem-1058	133	5	robustness	robustness	NOUN
eurjchem-1058	133	6	of	of	ADP
eurjchem-1058	133	7	the	the	DET
eurjchem-1058	133	8	developed	develop	VERB
eurjchem-1058	133	9	method	method	NOUN
eurjchem-1058	133	10	,	,	PUNCT
eurjchem-1058	133	11	chromatographic	chromatographic	ADJ
eurjchem-1058	133	12	conditions	condition	NOUN
eurjchem-1058	133	13	were	be	AUX
eurjchem-1058	133	14	deliberately	deliberately	ADV
eurjchem-1058	133	15	altered	alter	VERB
eurjchem-1058	133	16	.	.	PUNCT
eurjchem-1058	134	1	the	the	DET
eurjchem-1058	134	2	parameters	parameter	NOUN
eurjchem-1058	134	3	selected	select	VERB
eurjchem-1058	134	4	were	be	AUX
eurjchem-1058	134	5	change	change	NOUN
eurjchem-1058	134	6	in	in	ADP
eurjchem-1058	134	7	flow	flow	NOUN
eurjchem-1058	134	8	rate	rate	NOUN
eurjchem-1058	134	9	(	(	PUNCT
eurjchem-1058	134	10	±0.2	±0.2	PROPN
eurjchem-1058	134	11	ml	ml	PROPN
eurjchem-1058	134	12	/	/	SYM
eurjchem-1058	134	13	min	min	NOUN
eurjchem-1058	134	14	)	)	PUNCT
eurjchem-1058	134	15	,	,	PUNCT
eurjchem-1058	134	16	change	change	NOUN
eurjchem-1058	134	17	in	in	ADP
eurjchem-1058	134	18	ph	ph	NOUN
eurjchem-1058	134	19	of	of	ADP
eurjchem-1058	134	20	the	the	DET
eurjchem-1058	134	21	buffer	buffer	NOUN
eurjchem-1058	134	22	(	(	PUNCT
eurjchem-1058	134	23	±0.2	±0.2	PROPN
eurjchem-1058	134	24	)	)	PUNCT
eurjchem-1058	134	25	,	,	PUNCT
eurjchem-1058	134	26	change	change	NOUN
eurjchem-1058	134	27	in	in	ADP
eurjchem-1058	134	28	the	the	DET
eurjchem-1058	134	29	ratio	ratio	NOUN
eurjchem-1058	134	30	of	of	ADP
eurjchem-1058	134	31	mobile	mobile	ADJ
eurjchem-1058	134	32	phase	phase	NOUN
eurjchem-1058	134	33	(	(	PUNCT
eurjchem-1058	134	34	±	±	NOUN
eurjchem-1058	134	35	4	4	NUM
eurjchem-1058	134	36	%	%	NOUN
eurjchem-1058	134	37	)	)	PUNCT
eurjchem-1058	134	38	and	and	CCONJ
eurjchem-1058	134	39	change	change	VERB
eurjchem-1058	134	40	in	in	ADP
eurjchem-1058	134	41	the	the	DET
eurjchem-1058	134	42	column	column	NOUN
eurjchem-1058	134	43	temperature	temperature	NOUN
eurjchem-1058	134	44	(	(	PUNCT
eurjchem-1058	134	45	±5	±5	VERB
eurjchem-1058	134	46	°	°	NOUN
eurjchem-1058	134	47	c	c	NOUN
eurjchem-1058	134	48	)	)	PUNCT
eurjchem-1058	134	49	,	,	PUNCT
eurjchem-1058	134	50	the	the	DET
eurjchem-1058	134	51	rest	rest	NOUN
eurjchem-1058	134	52	of	of	ADP
eurjchem-1058	134	53	the	the	DET
eurjchem-1058	134	54	chromatographic	chromatographic	ADJ
eurjchem-1058	134	55	conditions	condition	NOUN
eurjchem-1058	134	56	for	for	ADP
eurjchem-1058	134	57	each	each	DET
eurjchem-1058	134	58	alteration	alteration	NOUN
eurjchem-1058	134	59	study	study	NOUN
eurjchem-1058	134	60	was	be	AUX
eurjchem-1058	134	61	kept	keep	VERB
eurjchem-1058	134	62	constant	constant	ADJ
eurjchem-1058	134	63	.	.	PUNCT
eurjchem-1058	135	1	in	in	ADP
eurjchem-1058	135	2	all	all	DET
eurjchem-1058	135	3	the	the	DET
eurjchem-1058	135	4	deliberately	deliberately	ADV
eurjchem-1058	135	5	varied	varied	ADJ
eurjchem-1058	135	6	chromatographic	chromatographic	ADJ
eurjchem-1058	135	7	conditions	condition	NOUN
eurjchem-1058	135	8	,	,	PUNCT
eurjchem-1058	135	9	no	no	DET
eurjchem-1058	135	10	significant	significant	ADJ
eurjchem-1058	135	11	change	change	NOUN
eurjchem-1058	135	12	was	be	AUX
eurjchem-1058	135	13	observed	observe	VERB
eurjchem-1058	135	14	,	,	PUNCT
eurjchem-1058	135	15	which	which	PRON
eurjchem-1058	135	16	confirmed	confirm	VERB
eurjchem-1058	135	17	the	the	DET
eurjchem-1058	135	18	robustness	robustness	NOUN
eurjchem-1058	135	19	of	of	ADP
eurjchem-1058	135	20	the	the	DET
eurjchem-1058	135	21	developed	develop	VERB
eurjchem-1058	135	22	method	method	NOUN
eurjchem-1058	135	23	.	.	PUNCT
eurjchem-1058	136	1	figure	figure	NOUN
eurjchem-1058	136	2	3	3	NUM
eurjchem-1058	136	3	.	.	PUNCT
eurjchem-1058	136	4	typical	typical	ADJ
eurjchem-1058	136	5	chromatogram	chromatogram	PROPN
eurjchem-1058	136	6	for	for	ADP
eurjchem-1058	136	7	lod	lod	PROPN
eurjchem-1058	136	8	.	.	PROPN
eurjchem-1058	137	1	4	4	X
eurjchem-1058	137	2	.	.	X
eurjchem-1058	137	3	conclusion	conclusion	NOUN
eurjchem-1058	137	4	a	a	DET
eurjchem-1058	137	5	new	new	ADJ
eurjchem-1058	137	6	gradient	gradient	NOUN
eurjchem-1058	137	7	rp‐hplc	rp‐hplc	PROPN
eurjchem-1058	137	8	method	method	NOUN
eurjchem-1058	137	9	was	be	AUX
eurjchem-1058	137	10	developed	develop	VERB
eurjchem-1058	137	11	for	for	ADP
eurjchem-1058	137	12	the	the	DET
eurjchem-1058	137	13	separation	separation	NOUN
eurjchem-1058	137	14	and	and	CCONJ
eurjchem-1058	137	15	determination	determination	NOUN
eurjchem-1058	137	16	of	of	ADP
eurjchem-1058	137	17	process	process	NOUN
eurjchem-1058	137	18	related	relate	VERB
eurjchem-1058	137	19	impurities	impurity	NOUN
eurjchem-1058	137	20	in	in	ADP
eurjchem-1058	137	21	pioglitazone	pioglitazone	NOUN
eurjchem-1058	137	22	hydrochloride	hydrochloride	NOUN
eurjchem-1058	137	23	and	and	CCONJ
eurjchem-1058	137	24	validated	validate	VERB
eurjchem-1058	137	25	as	as	ADP
eurjchem-1058	137	26	per	per	ADP
eurjchem-1058	137	27	ich	ich	NOUN
eurjchem-1058	137	28	guidelines	guideline	NOUN
eurjchem-1058	137	29	.	.	PUNCT
eurjchem-1058	138	1	the	the	DET
eurjchem-1058	138	2	method	method	NOUN
eurjchem-1058	138	3	was	be	AUX
eurjchem-1058	138	4	found	find	VERB
eurjchem-1058	138	5	to	to	PART
eurjchem-1058	138	6	be	be	AUX
eurjchem-1058	138	7	simple	simple	ADJ
eurjchem-1058	138	8	,	,	PUNCT
eurjchem-1058	138	9	selective	selective	ADJ
eurjchem-1058	138	10	,	,	PUNCT
eurjchem-1058	138	11	precise	precise	ADJ
eurjchem-1058	138	12	,	,	PUNCT
eurjchem-1058	138	13	sensitive	sensitive	ADJ
eurjchem-1058	138	14	,	,	PUNCT
eurjchem-1058	138	15	robust	robust	ADJ
eurjchem-1058	138	16	and	and	CCONJ
eurjchem-1058	138	17	accurate	accurate	ADJ
eurjchem-1058	138	18	.	.	PUNCT
eurjchem-1058	139	1	therefore	therefore	ADV
eurjchem-1058	139	2	,	,	PUNCT
eurjchem-1058	139	3	this	this	DET
eurjchem-1058	139	4	method	method	NOUN
eurjchem-1058	139	5	can	can	AUX
eurjchem-1058	139	6	be	be	AUX
eurjchem-1058	139	7	used	use	VERB
eurjchem-1058	139	8	for	for	ADP
eurjchem-1058	139	9	routine	routine	ADJ
eurjchem-1058	139	10	testing	testing	NOUN
eurjchem-1058	139	11	as	as	ADV
eurjchem-1058	139	12	well	well	ADV
eurjchem-1058	139	13	as	as	ADP
eurjchem-1058	139	14	stability	stability	NOUN
eurjchem-1058	139	15	analysis	analysis	NOUN
eurjchem-1058	139	16	of	of	ADP
eurjchem-1058	139	17	pioglitazone	pioglitazone	NOUN
eurjchem-1058	139	18	hydrochloride	hydrochloride	NOUN
eurjchem-1058	139	19	drug	drug	NOUN
eurjchem-1058	139	20	substance	substance	NOUN
eurjchem-1058	139	21	.	.	PUNCT
eurjchem-1058	140	1	all	all	DET
eurjchem-1058	140	2	statistical	statistical	ADJ
eurjchem-1058	140	3	results	result	NOUN
eurjchem-1058	140	4	(	(	PUNCT
eurjchem-1058	140	5	mean	mean	VERB
eurjchem-1058	140	6	,	,	PUNCT
eurjchem-1058	140	7	%	%	INTJ
eurjchem-1058	140	8	rsd	rsd	PROPN
eurjchem-1058	140	9	and	and	CCONJ
eurjchem-1058	140	10	%	%	NOUN
eurjchem-1058	140	11	recovery	recovery	NOUN
eurjchem-1058	140	12	)	)	PUNCT
eurjchem-1058	140	13	were	be	AUX
eurjchem-1058	140	14	within	within	ADP
eurjchem-1058	140	15	the	the	DET
eurjchem-1058	140	16	acceptance	acceptance	NOUN
eurjchem-1058	140	17	criteria	criterion	NOUN
eurjchem-1058	140	18	.	.	PUNCT
eurjchem-1058	141	1	acknowledgements	acknowledgement	NOUN
eurjchem-1058	141	2	one	one	NUM
eurjchem-1058	141	3	of	of	ADP
eurjchem-1058	141	4	the	the	DET
eurjchem-1058	141	5	authors	author	NOUN
eurjchem-1058	141	6	venkata	venkata	PROPN
eurjchem-1058	141	7	raj	raj	PROPN
eurjchem-1058	141	8	kumar	kumar	PROPN
eurjchem-1058	141	9	prava	prava	PROPN
eurjchem-1058	141	10	is	be	AUX
eurjchem-1058	141	11	thankful	thankful	ADJ
eurjchem-1058	141	12	to	to	ADP
eurjchem-1058	141	13	pharmazell	pharmazell	VERB
eurjchem-1058	141	14	research	research	NOUN
eurjchem-1058	141	15	centre	centre	NOUN
eurjchem-1058	141	16	,	,	PUNCT
eurjchem-1058	141	17	visakhapatnam	visakhapatnam	PROPN
eurjchem-1058	141	18	,	,	PUNCT
eurjchem-1058	141	19	for	for	ADP
eurjchem-1058	141	20	providing	provide	VERB
eurjchem-1058	141	21	necessary	necessary	ADJ
eurjchem-1058	141	22	facilities	facility	NOUN
eurjchem-1058	141	23	to	to	PART
eurjchem-1058	141	24	carry	carry	VERB
eurjchem-1058	141	25	out	out	ADP
eurjchem-1058	141	26	research	research	NOUN
eurjchem-1058	141	27	work	work	NOUN
eurjchem-1058	141	28	.	.	PUNCT
eurjchem-1058	142	1	474	474	NUM
eurjchem-1058	142	2	prava	prava	NOUN
eurjchem-1058	142	3	and	and	CCONJ
eurjchem-1058	142	4	seru	seru	PROPN
eurjchem-1058	142	5	/	/	SYM
eurjchem-1058	142	6	european	european	PROPN
eurjchem-1058	142	7	journal	journal	PROPN
eurjchem-1058	142	8	of	of	ADP
eurjchem-1058	142	9	chemistry	chemistry	NOUN
eurjchem-1058	142	10	5	5	NUM
eurjchem-1058	142	11	(	(	PUNCT
eurjchem-1058	142	12	3	3	NUM
eurjchem-1058	142	13	)	)	PUNCT
eurjchem-1058	142	14	(	(	PUNCT
eurjchem-1058	142	15	2014	2014	NUM
eurjchem-1058	142	16	)	)	PUNCT
eurjchem-1058	142	17	469‐474	469‐474	PROPN
eurjchem-1058	142	18	references	reference	NOUN
eurjchem-1058	142	19	[	[	X
eurjchem-1058	142	20	1	1	NUM
eurjchem-1058	142	21	]	]	PUNCT
eurjchem-1058	142	22	.	.	PUNCT
eurjchem-1058	143	1	gillies	gillie	NOUN
eurjchem-1058	143	2	,	,	PUNCT
eurjchem-1058	143	3	p.	p.	PROPN
eurjchem-1058	143	4	s.	s.	PROPN
eurjchem-1058	143	5	;	;	PUNCT
eurjchem-1058	143	6	dunn	dunn	PROPN
eurjchem-1058	143	7	,	,	PUNCT
eurjchem-1058	143	8	c.	c.	PROPN
eurjchem-1058	143	9	j.	j.	PROPN
eurjchem-1058	143	10	drugs	drugs	PROPN
eurjchem-1058	143	11	.	.	PUNCT
eurjchem-1058	144	1	2000	2000	NUM
eurjchem-1058	144	2	,	,	PUNCT
eurjchem-1058	144	3	60	60	NUM
eurjchem-1058	144	4	,	,	PUNCT
eurjchem-1058	144	5	333‐343	333‐343	PROPN
eurjchem-1058	144	6	.	.	PUNCT
eurjchem-1058	145	1	[	[	X
eurjchem-1058	145	2	2	2	NUM
eurjchem-1058	145	3	]	]	PUNCT
eurjchem-1058	145	4	.	.	PUNCT
eurjchem-1058	146	1	diamant	diamant	NOUN
eurjchem-1058	146	2	,	,	PUNCT
eurjchem-1058	146	3	m.	m.	NOUN
eurjchem-1058	146	4	;	;	PUNCT
eurjchem-1058	146	5	heine	heine	PROPN
eurjchem-1058	146	6	,	,	PUNCT
eurjchem-1058	146	7	r.	r.	PROPN
eurjchem-1058	146	8	j.	j.	PROPN
eurjchem-1058	146	9	drugs	drugs	PROPN
eurjchem-1058	146	10	.	.	PUNCT
eurjchem-1058	147	1	2003	2003	NUM
eurjchem-1058	147	2	,	,	PUNCT
eurjchem-1058	147	3	63	63	NUM
eurjchem-1058	147	4	,	,	PUNCT
eurjchem-1058	147	5	1373‐1405	1373‐1405	NUM
eurjchem-1058	147	6	.	.	PUNCT
eurjchem-1058	148	1	[	[	X
eurjchem-1058	148	2	3	3	NUM
eurjchem-1058	148	3	]	]	PUNCT
eurjchem-1058	148	4	.	.	PUNCT
eurjchem-1058	149	1	madan	madan	PROPN
eurjchem-1058	149	2	,	,	PUNCT
eurjchem-1058	149	3	p.	p.	PROPN
eurjchem-1058	149	4	cmaj	cmaj	PROPN
eurjchem-1058	149	5	2005	2005	NUM
eurjchem-1058	149	6	,	,	PUNCT
eurjchem-1058	149	7	173	173	NUM
eurjchem-1058	149	8	,	,	PUNCT
eurjchem-1058	149	9	344‐345	344‐345	NUM
eurjchem-1058	149	10	.	.	PUNCT
eurjchem-1058	150	1	[	[	X
eurjchem-1058	150	2	4	4	NUM
eurjchem-1058	150	3	]	]	PUNCT
eurjchem-1058	150	4	.	.	PUNCT
eurjchem-1058	150	5	brunton	brunton	PROPN
eurjchem-1058	150	6	,	,	PUNCT
eurjchem-1058	150	7	l.	l.	PROPN
eurjchem-1058	150	8	l.	l.	PROPN
eurjchem-1058	150	9	;	;	PUNCT
eurjchem-1058	150	10	lazo	lazo	PROPN
eurjchem-1058	150	11	,	,	PUNCT
eurjchem-1058	150	12	j.	j.	PROPN
eurjchem-1058	150	13	s.	s.	PROPN
eurjchem-1058	150	14	;	;	PUNCT
eurjchem-1058	150	15	parker	parker	PROPN
eurjchem-1058	150	16	,	,	PUNCT
eurjchem-1058	150	17	k.	k.	PROPN
eurjchem-1058	150	18	l.	l.	PROPN
eurjchem-1058	150	19	goodman	goodman	PROPN
eurjchem-1058	150	20	&	&	CCONJ
eurjchem-1058	150	21	gilman	gilman	PROPN
eurjchem-1058	150	22	’s	’s	PART
eurjchem-1058	150	23	the	the	DET
eurjchem-1058	150	24	pharmacological	pharmacological	ADJ
eurjchem-1058	150	25	basis	basis	NOUN
eurjchem-1058	150	26	of	of	ADP
eurjchem-1058	150	27	therapeutics	therapeutic	NOUN
eurjchem-1058	150	28	.	.	PUNCT
eurjchem-1058	151	1	10th	10th	ADJ
eurjchem-1058	151	2	edi	edi	PROPN
eurjchem-1058	151	3	.	.	PROPN
eurjchem-1058	151	4	new	new	PROPN
eurjchem-1058	151	5	york	york	PROPN
eurjchem-1058	151	6	,	,	PUNCT
eurjchem-1058	151	7	mcgraw‐	mcgraw‐	VERB
eurjchem-1058	151	8	hill	hill	PROPN
eurjchem-1058	151	9	,	,	PUNCT
eurjchem-1058	151	10	2001	2001	NUM
eurjchem-1058	151	11	.	.	PUNCT
eurjchem-1058	152	1	[	[	X
eurjchem-1058	152	2	5	5	NUM
eurjchem-1058	152	3	]	]	PUNCT
eurjchem-1058	152	4	.	.	PUNCT
eurjchem-1058	152	5	lacy	lacy	NOUN
eurjchem-1058	152	6	,	,	PUNCT
eurjchem-1058	152	7	c.	c.	PROPN
eurjchem-1058	152	8	f.	f.	PROPN
eurjchem-1058	152	9	;	;	PUNCT
eurjchem-1058	152	10	armstrong	armstrong	PROPN
eurjchem-1058	152	11	,	,	PUNCT
eurjchem-1058	152	12	l.	l.	PROPN
eurjchem-1058	152	13	l.	l.	PROPN
eurjchem-1058	152	14	;	;	PUNCT
eurjchem-1058	152	15	goldman	goldman	NOUN
eurjchem-1058	152	16	,	,	PUNCT
eurjchem-1058	152	17	m.	m.	NOUN
eurjchem-1058	152	18	p.	p.	NOUN
eurjchem-1058	152	19	;	;	PUNCT
eurjchem-1058	152	20	lance	lance	PROPN
eurjchem-1058	152	21	,	,	PUNCT
eurjchem-1058	152	22	l.	l.	PROPN
eurjchem-1058	152	23	l.	l.	PROPN
eurjchem-1058	152	24	drug	drug	PROPN
eurjchem-1058	152	25	information	information	PROPN
eurjchem-1058	152	26	handbook	handbook	NOUN
eurjchem-1058	152	27	2000‐2001	2000‐2001	NUM
eurjchem-1058	152	28	.	.	PUNCT
eurjchem-1058	153	1	8th	8th	PROPN
eurjchem-1058	153	2	edi	edi	PROPN
eurjchem-1058	153	3	.	.	PROPN
eurjchem-1058	153	4	cleveland	cleveland	PROPN
eurjchem-1058	153	5	,	,	PUNCT
eurjchem-1058	153	6	lexi‐comp	lexi‐comp	PROPN
eurjchem-1058	153	7	.	.	PROPN
eurjchem-1058	153	8	,	,	PUNCT
eurjchem-1058	153	9	2000	2000	NUM
eurjchem-1058	153	10	.	.	PUNCT
eurjchem-1058	154	1	[	[	X
eurjchem-1058	154	2	6	6	NUM
eurjchem-1058	154	3	]	]	PUNCT
eurjchem-1058	154	4	.	.	PUNCT
eurjchem-1058	155	1	eckland	eckland	PROPN
eurjchem-1058	155	2	,	,	PUNCT
eurjchem-1058	155	3	d.	d.	PROPN
eurjchem-1058	155	4	a.	a.	PROPN
eurjchem-1058	155	5	;	;	PUNCT
eurjchem-1058	155	6	danhof	danhof	NOUN
eurjchem-1058	155	7	,	,	PUNCT
eurjchem-1058	155	8	m.	m.	NOUN
eurjchem-1058	155	9	exp	exp	PROPN
eurjchem-1058	155	10	.	.	PUNCT
eurjchem-1058	156	1	clin	clin	PROPN
eurjchem-1058	156	2	.	.	PUNCT
eurjchem-1058	156	3	endocrinol	endocrinol	PROPN
eurjchem-1058	156	4	.	.	PUNCT
eurjchem-1058	157	1	diab	diab	PROPN
eurjchem-1058	157	2	.	.	PUNCT
eurjchem-1058	158	1	2000	2000	NUM
eurjchem-1058	158	2	,	,	PUNCT
eurjchem-1058	158	3	108	108	NUM
eurjchem-1058	158	4	,	,	PUNCT
eurjchem-1058	158	5	234‐	234‐	PROPN
eurjchem-1058	158	6	242	242	NUM
eurjchem-1058	158	7	.	.	PUNCT
eurjchem-1058	159	1	[	[	X
eurjchem-1058	159	2	7	7	NUM
eurjchem-1058	159	3	]	]	PUNCT
eurjchem-1058	159	4	.	.	PUNCT
eurjchem-1058	159	5	colca	colca	PROPN
eurjchem-1058	159	6	,	,	PUNCT
eurjchem-1058	159	7	j.	j.	PROPN
eurjchem-1058	159	8	r.	r.	PROPN
eurjchem-1058	159	9	;	;	PUNCT
eurjchem-1058	159	10	mcdonald	mcdonald	PROPN
eurjchem-1058	159	11	,	,	PUNCT
eurjchem-1058	159	12	w.	w.	PROPN
eurjchem-1058	159	13	g.	g.	PROPN
eurjchem-1058	159	14	;	;	PUNCT
eurjchem-1058	159	15	waldon	waldon	PROPN
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eurjchem-1058	159	17	d.	d.	PROPN
eurjchem-1058	159	18	j.	j.	PROPN
eurjchem-1058	159	19	;	;	PUNCT
eurjchem-1058	159	20	leone	leone	PROPN
eurjchem-1058	159	21	,	,	PUNCT
eurjchem-1058	159	22	j.	j.	PROPN
eurjchem-1058	159	23	w.	w.	PROPN
eurjchem-1058	159	24	;	;	PUNCT
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eurjchem-1058	159	27	j.	j.	PROPN
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eurjchem-1058	160	2	,	,	PUNCT
eurjchem-1058	160	3	c.	c.	PROPN
eurjchem-1058	160	4	a.	a.	PROPN
eurjchem-1058	160	5	;	;	PUNCT
eurjchem-1058	160	6	lund	lund	PROPN
eurjchem-1058	160	7	,	,	PUNCT
eurjchem-1058	160	8	e.	e.	PROPN
eurjchem-1058	160	9	t.	t.	PROPN
eurjchem-1058	160	10	;	;	PUNCT
eurjchem-1058	160	11	mathews	mathews	PROPN
eurjchem-1058	160	12	,	,	PUNCT
eurjchem-1058	160	13	w.	w.	PROPN
eurjchem-1058	160	14	r.	r.	PROPN
eurjchem-1058	160	15	am	am	PROPN
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eurjchem-1058	161	1	j.	j.	PROPN
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eurjchem-1058	161	3	.	.	PUNCT
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eurjchem-1058	162	2	.	.	PUNCT
eurjchem-1058	163	1	metab	metab	PROPN
eurjchem-1058	163	2	.	.	PUNCT
eurjchem-1058	164	1	2004	2004	NUM
eurjchem-1058	164	2	,	,	PUNCT
eurjchem-1058	164	3	286(2	286(2	NUM
eurjchem-1058	164	4	)	)	PUNCT
eurjchem-1058	164	5	,	,	PUNCT
eurjchem-1058	164	6	252‐260	252‐260	NUM
eurjchem-1058	164	7	.	.	PUNCT
eurjchem-1058	165	1	[	[	X
eurjchem-1058	165	2	8	8	NUM
eurjchem-1058	165	3	]	]	PUNCT
eurjchem-1058	165	4	.	.	PUNCT
eurjchem-1058	165	5	paddock	paddock	NOUN
eurjchem-1058	165	6	,	,	PUNCT
eurjchem-1058	165	7	m.	m.	NOUN
eurjchem-1058	165	8	l.	l.	PROPN
eurjchem-1058	165	9	;	;	PUNCT
eurjchem-1058	165	10	willy	willy	ADV
eurjchem-1058	165	11	,	,	PUNCT
eurjchem-1058	165	12	s.	s.	PROPN
eurjchem-1058	165	13	e.	e.	PROPN
eurjchem-1058	165	14	;	;	PUNCT
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eurjchem-1058	165	16	,	,	PUNCT
eurjchem-1058	165	17	h.	h.	PROPN
eurjchem-1058	165	18	l.	l.	PROPN
eurjchem-1058	165	19	;	;	PUNCT
eurjchem-1058	165	20	cohen	cohen	PROPN
eurjchem-1058	165	21	,	,	PUNCT
eurjchem-1058	165	22	a.	a.	PROPN
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eurjchem-1058	165	24	;	;	PUNCT
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eurjchem-1058	165	26	,	,	PUNCT
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eurjchem-1058	165	28	;	;	PUNCT
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eurjchem-1058	165	30	,	,	PUNCT
eurjchem-1058	165	31	e.	e.	PROPN
eurjchem-1058	165	32	c.	c.	PROPN
eurjchem-1058	165	33	;	;	PUNCT
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eurjchem-1058	165	35	,	,	PUNCT
eurjchem-1058	165	36	d.	d.	PROPN
eurjchem-1058	165	37	;	;	PUNCT
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eurjchem-1058	165	39	,	,	PUNCT
eurjchem-1058	165	40	a.	a.	PROPN
eurjchem-1058	165	41	n.	n.	PROPN
eurjchem-1058	165	42	proc	proc	PROPN
eurjchem-1058	165	43	.	.	PUNCT
eurjchem-1058	166	1	natl	natl	PROPN
eurjchem-1058	166	2	.	.	PUNCT
eurjchem-1058	167	1	acad	acad	PROPN
eurjchem-1058	167	2	.	.	PUNCT
eurjchem-1058	168	1	sci	sci	PROPN
eurjchem-1058	168	2	.	.	PUNCT
eurjchem-1058	168	3	u.	u.	PROPN
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eurjchem-1058	168	7	,	,	PUNCT
eurjchem-1058	168	8	104(36	104(36	NUM
eurjchem-1058	168	9	)	)	PUNCT
eurjchem-1058	168	10	,	,	PUNCT
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eurjchem-1058	168	12	.	.	PUNCT
eurjchem-1058	169	1	[	[	X
eurjchem-1058	169	2	9	9	NUM
eurjchem-1058	169	3	]	]	PUNCT
eurjchem-1058	169	4	.	.	PUNCT
eurjchem-1058	170	1	the	the	DET
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eurjchem-1058	170	4	,	,	PUNCT
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eurjchem-1058	170	7	.	.	PROPN
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eurjchem-1058	170	12	.	.	PROPN
eurjchem-1058	170	13	,	,	PUNCT
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eurjchem-1058	170	15	,	,	PUNCT
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eurjchem-1058	170	17	,	,	PUNCT
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eurjchem-1058	170	19	.	.	PUNCT
eurjchem-1058	171	1	[	[	X
eurjchem-1058	171	2	10	10	NUM
eurjchem-1058	171	3	]	]	PUNCT
eurjchem-1058	171	4	.	.	PUNCT
eurjchem-1058	172	1	url	url	PROPN
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eurjchem-1058	173	2	11	11	NUM
eurjchem-1058	173	3	]	]	PUNCT
eurjchem-1058	173	4	.	.	PUNCT
eurjchem-1058	174	1	zhong	zhong	PROPN
eurjchem-1058	174	2	,	,	PUNCT
eurjchem-1058	174	3	w.	w.	PROPN
eurjchem-1058	174	4	z.	z.	PROPN
eurjchem-1058	174	5	;	;	PUNCT
eurjchem-1058	174	6	williams	williams	PROPN
eurjchem-1058	174	7	,	,	PUNCT
eurjchem-1058	174	8	m.	m.	PROPN
eurjchem-1058	174	9	g.	g.	PROPN
eurjchem-1058	174	10	j.	j.	PROPN
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eurjchem-1058	174	12	.	.	PUNCT
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eurjchem-1058	174	14	.	.	PUNCT
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eurjchem-1058	175	2	.	.	PUNCT
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eurjchem-1058	176	2	,	,	PUNCT
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eurjchem-1058	176	4	,	,	PUNCT
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eurjchem-1058	176	6	.	.	PUNCT
eurjchem-1058	177	1	[	[	X
eurjchem-1058	177	2	12	12	NUM
eurjchem-1058	177	3	]	]	PUNCT
eurjchem-1058	177	4	.	.	PUNCT
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eurjchem-1058	178	2	,	,	PUNCT
eurjchem-1058	178	3	k.	k.	PROPN
eurjchem-1058	178	4	;	;	PUNCT
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eurjchem-1058	178	6	,	,	PUNCT
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eurjchem-1058	178	8	;	;	PUNCT
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eurjchem-1058	178	10	,	,	PUNCT
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eurjchem-1058	178	18	.	.	PUNCT
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eurjchem-1058	179	3	,	,	PUNCT
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eurjchem-1058	179	5	,	,	PUNCT
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eurjchem-1058	179	7	.	.	PUNCT
eurjchem-1058	180	1	[	[	X
eurjchem-1058	180	2	13	13	NUM
eurjchem-1058	180	3	]	]	PUNCT
eurjchem-1058	180	4	.	.	PUNCT
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eurjchem-1058	181	2	,	,	PUNCT
eurjchem-1058	181	3	t.	t.	PROPN
eurjchem-1058	181	4	;	;	PUNCT
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eurjchem-1058	181	7	r.	r.	PROPN
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eurjchem-1058	181	9	;	;	PUNCT
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eurjchem-1058	181	11	,	,	PUNCT
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eurjchem-1058	181	16	.	.	PUNCT
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eurjchem-1058	182	2	.	.	PUNCT
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eurjchem-1058	183	2	.	.	PUNCT
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eurjchem-1058	184	2	,	,	PUNCT
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eurjchem-1058	184	4	,	,	PUNCT
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eurjchem-1058	184	6	.	.	PUNCT
eurjchem-1058	185	1	[	[	X
eurjchem-1058	185	2	14	14	NUM
eurjchem-1058	185	3	]	]	PUNCT
eurjchem-1058	185	4	.	.	PUNCT
eurjchem-1058	186	1	xue	xue	PROPN
eurjchem-1058	186	2	,	,	PUNCT
eurjchem-1058	186	3	y.	y.	PROPN
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eurjchem-1058	186	5	;	;	PUNCT
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eurjchem-1058	186	10	;	;	PUNCT
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eurjchem-1058	186	29	.	.	PUNCT
eurjchem-1058	187	1	b.	b.	PROPN
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eurjchem-1058	187	3	,	,	PUNCT
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eurjchem-1058	187	5	,	,	PUNCT
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eurjchem-1058	187	7	.	.	PUNCT
eurjchem-1058	188	1	[	[	X
eurjchem-1058	188	2	15	15	NUM
eurjchem-1058	188	3	]	]	PUNCT
eurjchem-1058	188	4	.	.	PUNCT
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eurjchem-1058	189	5	;	;	PUNCT
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eurjchem-1058	189	8	s.	s.	PROPN
eurjchem-1058	189	9	n.	n.	PROPN
eurjchem-1058	189	10	;	;	PUNCT
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eurjchem-1058	189	12	,	,	PUNCT
eurjchem-1058	189	13	s.	s.	PROPN
eurjchem-1058	189	14	;	;	PUNCT
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eurjchem-1058	189	18	;	;	PUNCT
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eurjchem-1058	189	26	,	,	PUNCT
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eurjchem-1058	189	28	.	.	PUNCT
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eurjchem-1058	190	2	16	16	NUM
eurjchem-1058	190	3	]	]	PUNCT
eurjchem-1058	190	4	.	.	PUNCT
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eurjchem-1058	190	6	,	,	PUNCT
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eurjchem-1058	190	8	;	;	PUNCT
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eurjchem-1058	190	10	,	,	PUNCT
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eurjchem-1058	190	12	;	;	PUNCT
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eurjchem-1058	190	18	.	.	PUNCT
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eurjchem-1058	191	3	,	,	PUNCT
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eurjchem-1058	191	5	,	,	PUNCT
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eurjchem-1058	191	7	.	.	PUNCT
eurjchem-1058	192	1	[	[	X
eurjchem-1058	192	2	17	17	NUM
eurjchem-1058	192	3	]	]	PUNCT
eurjchem-1058	192	4	.	.	PUNCT
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eurjchem-1058	193	8	.	.	PUNCT
eurjchem-1058	194	1	j.	j.	PROPN
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eurjchem-1058	194	3	.	.	PUNCT
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eurjchem-1058	195	2	.	.	PUNCT
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eurjchem-1058	195	4	.	.	PUNCT
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eurjchem-1058	196	2	,	,	PUNCT
eurjchem-1058	196	3	2(9	2(9	NUM
eurjchem-1058	196	4	)	)	PUNCT
eurjchem-1058	196	5	,	,	PUNCT
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eurjchem-1058	196	7	.	.	PUNCT
eurjchem-1058	197	1	[	[	X
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eurjchem-1058	197	3	]	]	PUNCT
eurjchem-1058	197	4	.	.	PUNCT
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eurjchem-1058	198	2	,	,	PUNCT
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eurjchem-1058	198	4	;	;	PUNCT
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eurjchem-1058	198	7	y.	y.	PROPN
eurjchem-1058	198	8	;	;	PUNCT
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eurjchem-1058	198	10	,	,	PUNCT
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eurjchem-1058	198	14	.	.	PUNCT
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eurjchem-1058	199	3	,	,	PUNCT
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eurjchem-1058	199	8	.	.	PUNCT
eurjchem-1058	200	1	[	[	X
eurjchem-1058	200	2	19	19	NUM
eurjchem-1058	200	3	]	]	PUNCT
eurjchem-1058	200	4	.	.	PUNCT
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eurjchem-1058	201	2	,	,	PUNCT
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eurjchem-1058	201	5	;	;	PUNCT
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eurjchem-1058	202	2	,	,	PUNCT
eurjchem-1058	202	3	592849	592849	NUM
eurjchem-1058	202	4	,	,	PUNCT
eurjchem-1058	202	5	1‐11	1‐11	NUM
eurjchem-1058	202	6	.	.	PUNCT
eurjchem-1058	203	1	[	[	X
eurjchem-1058	203	2	20	20	NUM
eurjchem-1058	203	3	]	]	PUNCT
eurjchem-1058	203	4	.	.	PUNCT
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eurjchem-1058	204	2	,	,	PUNCT
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eurjchem-1058	204	4	;	;	PUNCT
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