id sid tid token lemma pos eurjchem-11 1 1 microsoft microsoft PROPN eurjchem-11 1 2 word word PROPN eurjchem-11 1 3 european_journal_of_chemistry_1_1_2010_20_27_11 european_journal_of_chemistry_1_1_2010_20_27_11 VERB eurjchem-11 1 4 european european ADJ eurjchem-11 1 5     SPACE eurjchem-11 1 6 journal journal NOUN eurjchem-11 1 7     SPACE eurjchem-11 1 8 of of ADP eurjchem-11 1 9     SPACE eurjchem-11 1 10 chemistry chemistry NOUN eurjchem-11 1 11     SPACE eurjchem-11 1 12 1 1 NUM eurjchem-11 1 13     SPACE eurjchem-11 1 14 ( ( PUNCT eurjchem-11 1 15 1 1 NUM eurjchem-11 1 16 ) ) PUNCT eurjchem-11 1 17     SPACE eurjchem-11 1 18 ( ( PUNCT eurjchem-11 1 19 2010 2010 NUM eurjchem-11 1 20 ) ) PUNCT eurjchem-11 1 21     SPACE eurjchem-11 1 22 20‐27 20‐27 NOUN eurjchem-11 1 23         SPACE eurjchem-11 1 24 european european ADJ eurjchem-11 1 25     SPACE eurjchem-11 1 26 journal journal NOUN eurjchem-11 1 27     SPACE eurjchem-11 1 28 of of ADP eurjchem-11 1 29     SPACE eurjchem-11 1 30 chemistry chemistry NOUN eurjchem-11 1 31     SPACE eurjchem-11 1 32 issn issn VERB eurjchem-11 1 33     SPACE eurjchem-11 1 34 2153‐2249 2153‐2249 NUM eurjchem-11 1 35     SPACE eurjchem-11 1 36 ( ( PUNCT eurjchem-11 1 37 print print NOUN eurjchem-11 1 38 ) ) PUNCT eurjchem-11 1 39     SPACE eurjchem-11 1 40 / / SYM eurjchem-11 1 41     SPACE eurjchem-11 1 42 issn issn VERB eurjchem-11 1 43     SPACE eurjchem-11 1 44 2153‐2257 2153‐2257 NUM eurjchem-11 1 45     SPACE eurjchem-11 1 46 ( ( PUNCT eurjchem-11 1 47 online online ADJ eurjchem-11 1 48 ) ) PUNCT eurjchem-11 1 49     SPACE eurjchem-11 1 50   NOUN eurjchem-11 1 51     SPACE eurjchem-11 1 52 2010 2010 NUM eurjchem-11 1 53     SPACE eurjchem-11 1 54 eurjchem eurjchem NOUN eurjchem-11 1 55     SPACE eurjchem-11 1 56 doi:10.5155 doi:10.5155 PROPN eurjchem-11 1 57 / / SYM eurjchem-11 1 58 eurjchem.1.1.20‐27.11 eurjchem.1.1.20‐27.11 ADJ eurjchem-11 1 59                 SPACE eurjchem-11 1 60 european european ADJ eurjchem-11 1 61     SPACE eurjchem-11 1 62 journal journal NOUN eurjchem-11 1 63     SPACE eurjchem-11 1 64 of of ADP eurjchem-11 1 65     SPACE eurjchem-11 1 66 chemistry chemistry NOUN eurjchem-11 1 67     SPACE eurjchem-11 1 68 journal journal NOUN eurjchem-11 1 69     SPACE eurjchem-11 1 70 homepage homepage NOUN eurjchem-11 1 71 : : PUNCT eurjchem-11 1 72     SPACE eurjchem-11 1 73 www.eurjchem.com www.eurjchem.com NOUN eurjchem-11 1 74                     SPACE eurjchem-11 1 75 identification identification NOUN eurjchem-11 1 76     SPACE eurjchem-11 1 77 of of ADP eurjchem-11 1 78     SPACE eurjchem-11 1 79 degradation degradation NOUN eurjchem-11 1 80     SPACE eurjchem-11 1 81 products product NOUN eurjchem-11 1 82     SPACE eurjchem-11 1 83 in in ADP eurjchem-11 1 84     SPACE eurjchem-11 1 85 aripiprazole aripiprazole NOUN eurjchem-11 1 86     SPACE eurjchem-11 1 87 tablets tablet NOUN eurjchem-11 1 88     SPACE eurjchem-11 1 89 by by ADP eurjchem-11 1 90     SPACE eurjchem-11 1 91 lc‐qtof lc‐qtof PROPN eurjchem-11 1 92     SPACE eurjchem-11 1 93 mass mass PROPN eurjchem-11 1 94     SPACE eurjchem-11 1 95 spectrometry spectrometry NOUN eurjchem-11 1 96     SPACE eurjchem-11 1 97 gosula gosula PROPN eurjchem-11 1 98     SPACE eurjchem-11 1 99 venkat venkat PROPN eurjchem-11 1 100     SPACE eurjchem-11 1 101 rami rami PROPN eurjchem-11 1 102     SPACE eurjchem-11 1 103 reddya reddya NOUN eurjchem-11 1 104 , , PUNCT eurjchem-11 1 105     SPACE eurjchem-11 1 106 avvaru avvaru NOUN eurjchem-11 1 107     SPACE eurjchem-11 1 108 praveen praveen PROPN eurjchem-11 1 109     SPACE eurjchem-11 1 110 kumarb kumarb NOUN eurjchem-11 1 111 , , PUNCT eurjchem-11 1 112 * * NOUN eurjchem-11 1 113 , , PUNCT eurjchem-11 1 114     SPACE eurjchem-11 1 115 bobba bobba VERB eurjchem-11 1 116     SPACE eurjchem-11 1 117 venkateswara venkateswara NOUN eurjchem-11 1 118     SPACE eurjchem-11 1 119 reddya reddya NOUN eurjchem-11 1 120 , , PUNCT eurjchem-11 1 121     SPACE eurjchem-11 1 122 poonam poonam NOUN eurjchem-11 1 123     SPACE eurjchem-11 1 124 kumara kumara PROPN eurjchem-11 1 125 , , PUNCT eurjchem-11 1 126     SPACE eurjchem-11 1 127 and and CCONJ eurjchem-11 1 128     SPACE eurjchem-11 1 129 ham ham NOUN eurjchem-11 1 130     SPACE eurjchem-11 1 131 dutt dutt PROPN eurjchem-11 1 132     SPACE eurjchem-11 1 133 gauttama gauttama NOUN eurjchem-11 1 134     SPACE eurjchem-11 1 135 a a DET eurjchem-11 1 136     SPACE eurjchem-11 1 137 jubilant jubilant ADJ eurjchem-11 1 138     SPACE eurjchem-11 1 139 organosys organosy NOUN eurjchem-11 1 140     SPACE eurjchem-11 1 141 limited limit VERB eurjchem-11 1 142 , , PUNCT eurjchem-11 1 143     SPACE eurjchem-11 1 144 noida noida PROPN eurjchem-11 1 145 , , PUNCT eurjchem-11 1 146     SPACE eurjchem-11 1 147 utterpradesh utterpradesh ADJ eurjchem-11 1 148 , , PUNCT eurjchem-11 1 149     SPACE eurjchem-11 1 150 201301 201301 NUM eurjchem-11 1 151 , , PUNCT eurjchem-11 1 152     SPACE eurjchem-11 1 153 india india PROPN eurjchem-11 1 154     SPACE eurjchem-11 1 155 b b PROPN eurjchem-11 1 156     SPACE eurjchem-11 1 157 department department NOUN eurjchem-11 1 158     SPACE eurjchem-11 1 159 of of ADP eurjchem-11 1 160     SPACE eurjchem-11 1 161 chemistry chemistry NOUN eurjchem-11 1 162 , , PUNCT eurjchem-11 1 163     SPACE eurjchem-11 1 164 yeungnam yeungnam NOUN eurjchem-11 1 165     SPACE eurjchem-11 1 166 university university NOUN eurjchem-11 1 167 , , PUNCT eurjchem-11 1 168     SPACE eurjchem-11 1 169 gyeongsan gyeongsan ADJ eurjchem-11 1 170 , , PUNCT eurjchem-11 1 171     SPACE eurjchem-11 1 172 712749 712749 NUM eurjchem-11 1 173 , , PUNCT eurjchem-11 1 174     SPACE eurjchem-11 1 175 korea korea PROPN eurjchem-11 1 176     SPACE eurjchem-11 1 177 * * PROPN eurjchem-11 1 178 corresponding corresponding ADJ eurjchem-11 1 179     SPACE eurjchem-11 1 180 author author NOUN eurjchem-11 1 181     SPACE eurjchem-11 1 182 at at ADP eurjchem-11 1 183 : : PUNCT eurjchem-11 1 184     SPACE eurjchem-11 1 185 department department NOUN eurjchem-11 1 186     SPACE eurjchem-11 1 187 of of ADP eurjchem-11 1 188     SPACE eurjchem-11 1 189 chemistry chemistry NOUN eurjchem-11 1 190 , , PUNCT eurjchem-11 1 191     SPACE eurjchem-11 1 192 yeungnam yeungnam NOUN eurjchem-11 1 193     SPACE eurjchem-11 1 194 university university NOUN eurjchem-11 1 195 , , PUNCT eurjchem-11 1 196     SPACE eurjchem-11 1 197 gyeongsan gyeongsan ADJ eurjchem-11 1 198 , , PUNCT eurjchem-11 1 199     SPACE eurjchem-11 1 200 712749 712749 NUM eurjchem-11 1 201 , , PUNCT eurjchem-11 1 202     SPACE eurjchem-11 1 203 korea korea PROPN eurjchem-11 1 204 . . PUNCT eurjchem-11 1 205     SPACE eurjchem-11 2 1 tel tel PROPN eurjchem-11 2 2 . . PUNCT eurjchem-11 2 3 : : PUNCT eurjchem-11 2 4     SPACE eurjchem-11 3 1 +82.53.8102347 +82.53.8102347 ADJ eurjchem-11 3 2 ; ; PUNCT eurjchem-11 3 3     SPACE eurjchem-11 3 4 fax fax NOUN eurjchem-11 3 5 : : PUNCT eurjchem-11 3 6     SPACE eurjchem-11 3 7 +82.53.8104613 +82.53.8104613 PROPN eurjchem-11 3 8 . . PUNCT eurjchem-11 3 9     SPACE eurjchem-11 3 10 e­mail e­mail NOUN eurjchem-11 3 11     SPACE eurjchem-11 3 12 address address NOUN eurjchem-11 3 13 : : PUNCT eurjchem-11 3 14     SPACE eurjchem-11 3 15 drkumar.kr@gmail.com drkumar.kr@gmail.com PROPN eurjchem-11 3 16     SPACE eurjchem-11 3 17 ( ( PUNCT eurjchem-11 3 18 a. a. NOUN eurjchem-11 3 19     SPACE eurjchem-11 3 20 praveen praveen PROPN eurjchem-11 3 21     SPACE eurjchem-11 3 22 kumar kumar PROPN eurjchem-11 3 23 ) ) PUNCT eurjchem-11 3 24 . . PUNCT eurjchem-11 3 25                                     SPACE eurjchem-11 4 1 article article NOUN eurjchem-11 4 2     SPACE eurjchem-11 4 3 information information NOUN eurjchem-11 4 4         SPACE eurjchem-11 4 5 abstract abstract ADJ eurjchem-11 4 6 received receive VERB eurjchem-11 4 7 : : PUNCT eurjchem-11 4 8     SPACE eurjchem-11 4 9 15 15 NUM eurjchem-11 4 10     SPACE eurjchem-11 4 11 february february PROPN eurjchem-11 4 12     SPACE eurjchem-11 4 13 2010 2010 NUM eurjchem-11 4 14     SPACE eurjchem-11 4 15 received receive VERB eurjchem-11 4 16     SPACE eurjchem-11 4 17 in in ADP eurjchem-11 4 18     SPACE eurjchem-11 4 19 revised revise VERB eurjchem-11 4 20     SPACE eurjchem-11 4 21 form form NOUN eurjchem-11 4 22 : : PUNCT eurjchem-11 4 23     SPACE eurjchem-11 4 24 4 4 NUM eurjchem-11 4 25     SPACE eurjchem-11 4 26 march march PROPN eurjchem-11 4 27     SPACE eurjchem-11 4 28 2010 2010 NUM eurjchem-11 4 29     SPACE eurjchem-11 4 30 accepted accept VERB eurjchem-11 4 31 : : PUNCT eurjchem-11 4 32     SPACE eurjchem-11 4 33 10 10 NUM eurjchem-11 4 34     SPACE eurjchem-11 4 35 march march PROPN eurjchem-11 4 36     SPACE eurjchem-11 4 37 2010 2010 NUM eurjchem-11 4 38     SPACE eurjchem-11 4 39 online online NOUN eurjchem-11 4 40 : : PUNCT eurjchem-11 4 41     SPACE eurjchem-11 4 42 31 31 NUM eurjchem-11 4 43     SPACE eurjchem-11 4 44 march march PROPN eurjchem-11 4 45     SPACE eurjchem-11 4 46 2010 2010 NUM eurjchem-11 4 47     SPACE eurjchem-11 4 48 keywords keyword VERB eurjchem-11 4 49         SPACE eurjchem-11 4 50 this this DET eurjchem-11 4 51     SPACE eurjchem-11 4 52 paper paper NOUN eurjchem-11 4 53     SPACE eurjchem-11 4 54 describes describe VERB eurjchem-11 4 55     SPACE eurjchem-11 4 56 the the DET eurjchem-11 4 57     SPACE eurjchem-11 4 58 separation separation NOUN eurjchem-11 4 59 , , PUNCT eurjchem-11 4 60     SPACE eurjchem-11 4 61 identification identification NOUN eurjchem-11 4 62     SPACE eurjchem-11 4 63 and and CCONJ eurjchem-11 4 64     SPACE eurjchem-11 4 65 proposed propose VERB eurjchem-11 4 66     SPACE eurjchem-11 4 67 structures structure NOUN eurjchem-11 4 68     SPACE eurjchem-11 4 69 of of ADP eurjchem-11 4 70     SPACE eurjchem-11 4 71 the the DET eurjchem-11 4 72     SPACE eurjchem-11 4 73 degradation degradation NOUN eurjchem-11 4 74     SPACE eurjchem-11 4 75 products product NOUN eurjchem-11 4 76     SPACE eurjchem-11 4 77 formed form VERB eurjchem-11 4 78     SPACE eurjchem-11 4 79 during during ADP eurjchem-11 4 80     SPACE eurjchem-11 4 81 degradation degradation NOUN eurjchem-11 4 82     SPACE eurjchem-11 4 83 analysis analysis NOUN eurjchem-11 4 84     SPACE eurjchem-11 4 85 of of ADP eurjchem-11 4 86     SPACE eurjchem-11 4 87 aripiprazole aripiprazole NOUN eurjchem-11 4 88     SPACE eurjchem-11 4 89 in in ADP eurjchem-11 4 90     SPACE eurjchem-11 4 91 its its PRON eurjchem-11 4 92     SPACE eurjchem-11 4 93 final final ADJ eurjchem-11 4 94     SPACE eurjchem-11 4 95 dosage dosage NOUN eurjchem-11 4 96     SPACE eurjchem-11 4 97 form form NOUN eurjchem-11 4 98     SPACE eurjchem-11 4 99 by by ADP eurjchem-11 4 100     SPACE eurjchem-11 4 101 high high ADJ eurjchem-11 4 102     SPACE eurjchem-11 4 103 performance performance NOUN eurjchem-11 4 104     SPACE eurjchem-11 4 105 liquid liquid NOUN eurjchem-11 4 106     SPACE eurjchem-11 4 107 chromatography chromatography NOUN eurjchem-11 4 108     SPACE eurjchem-11 4 109 ( ( PUNCT eurjchem-11 4 110 hplc hplc PROPN eurjchem-11 4 111 ) ) PUNCT eurjchem-11 4 112     SPACE eurjchem-11 4 113 coupled couple VERB eurjchem-11 4 114     SPACE eurjchem-11 4 115 with with ADP eurjchem-11 4 116     SPACE eurjchem-11 4 117 quadrupole quadrupole NOUN eurjchem-11 4 118     SPACE eurjchem-11 4 119 time‐of‐ time‐of‐ PROPN eurjchem-11 4 120 flight flight NOUN eurjchem-11 4 121     SPACE eurjchem-11 4 122 mass mass PROPN eurjchem-11 4 123     SPACE eurjchem-11 4 124 spectrometry spectrometry NOUN eurjchem-11 4 125     SPACE eurjchem-11 4 126 ( ( PUNCT eurjchem-11 4 127 qtof‐ms qtof‐ms NUM eurjchem-11 4 128 ) ) PUNCT eurjchem-11 4 129 . . PUNCT eurjchem-11 4 130     SPACE eurjchem-11 5 1 the the DET eurjchem-11 5 2     SPACE eurjchem-11 5 3 drug drug NOUN eurjchem-11 5 4     SPACE eurjchem-11 5 5 product product NOUN eurjchem-11 5 6     SPACE eurjchem-11 5 7 was be AUX eurjchem-11 5 8     SPACE eurjchem-11 5 9 subjected subject VERB eurjchem-11 5 10     SPACE eurjchem-11 5 11 to to PART eurjchem-11 5 12     SPACE eurjchem-11 5 13 stress stress NOUN eurjchem-11 5 14     SPACE eurjchem-11 5 15 conditions condition NOUN eurjchem-11 5 16     SPACE eurjchem-11 5 17 including include VERB eurjchem-11 5 18     SPACE eurjchem-11 5 19 acid acid ADJ eurjchem-11 5 20 , , PUNCT eurjchem-11 5 21     SPACE eurjchem-11 5 22 base base NOUN eurjchem-11 5 23 , , PUNCT eurjchem-11 5 24     SPACE eurjchem-11 5 25 thermal thermal ADJ eurjchem-11 5 26 , , PUNCT eurjchem-11 5 27     SPACE eurjchem-11 5 28 oxidation oxidation NOUN eurjchem-11 5 29 , , PUNCT eurjchem-11 5 30     SPACE eurjchem-11 5 31 humidity humidity NOUN eurjchem-11 5 32     SPACE eurjchem-11 5 33 and and CCONJ eurjchem-11 5 34     SPACE eurjchem-11 5 35 photolytic photolytic ADJ eurjchem-11 5 36     SPACE eurjchem-11 5 37 degradations degradation NOUN eurjchem-11 5 38 . . PUNCT eurjchem-11 5 39     SPACE eurjchem-11 6 1 aripiprazole aripiprazole PROPN eurjchem-11 6 2     SPACE eurjchem-11 6 3 was be AUX eurjchem-11 6 4     SPACE eurjchem-11 6 5 found find VERB eurjchem-11 6 6     SPACE eurjchem-11 6 7 to to PART eurjchem-11 6 8     SPACE eurjchem-11 6 9 be be AUX eurjchem-11 6 10     SPACE eurjchem-11 6 11 stable stable ADJ eurjchem-11 6 12     SPACE eurjchem-11 6 13 in in ADP eurjchem-11 6 14     SPACE eurjchem-11 6 15 all all DET eurjchem-11 6 16     SPACE eurjchem-11 6 17 conditions condition NOUN eurjchem-11 6 18     SPACE eurjchem-11 6 19 except except SCONJ eurjchem-11 6 20     SPACE eurjchem-11 6 21 in in ADP eurjchem-11 6 22     SPACE eurjchem-11 6 23 thermal thermal ADJ eurjchem-11 6 24     SPACE eurjchem-11 6 25 and and CCONJ eurjchem-11 6 26     SPACE eurjchem-11 6 27 peroxide peroxide NOUN eurjchem-11 6 28     SPACE eurjchem-11 6 29 degradations degradation NOUN eurjchem-11 6 30 . . PUNCT eurjchem-11 6 31     SPACE eurjchem-11 7 1 the the DET eurjchem-11 7 2     SPACE eurjchem-11 7 3 degradation degradation NOUN eurjchem-11 7 4     SPACE eurjchem-11 7 5 impurities impurity NOUN eurjchem-11 7 6     SPACE eurjchem-11 7 7 were be AUX eurjchem-11 7 8     SPACE eurjchem-11 7 9 first first ADV eurjchem-11 7 10     SPACE eurjchem-11 7 11 separated separate VERB eurjchem-11 7 12     SPACE eurjchem-11 7 13 by by ADP eurjchem-11 7 14     SPACE eurjchem-11 7 15 hplc hplc NOUN eurjchem-11 7 16     SPACE eurjchem-11 7 17 and and CCONJ eurjchem-11 7 18     SPACE eurjchem-11 7 19 then then ADV eurjchem-11 7 20     SPACE eurjchem-11 7 21 identified identify VERB eurjchem-11 7 22     SPACE eurjchem-11 7 23 using use VERB eurjchem-11 7 24     SPACE eurjchem-11 7 25 qtof qtof PROPN eurjchem-11 7 26     SPACE eurjchem-11 7 27 mass mass PROPN eurjchem-11 7 28     SPACE eurjchem-11 7 29 spectrometry spectrometry NOUN eurjchem-11 7 30 . . PUNCT eurjchem-11 7 31     SPACE eurjchem-11 8 1 qtof qtof PROPN eurjchem-11 8 2     SPACE eurjchem-11 8 3 mass mass PROPN eurjchem-11 8 4     SPACE eurjchem-11 8 5 spectrometer spectrometer NOUN eurjchem-11 8 6     SPACE eurjchem-11 8 7 provided provide VERB eurjchem-11 8 8     SPACE eurjchem-11 8 9 high high ADJ eurjchem-11 8 10     SPACE eurjchem-11 8 11 order order NOUN eurjchem-11 8 12     SPACE eurjchem-11 8 13 of of ADP eurjchem-11 8 14     SPACE eurjchem-11 8 15 mass mass ADJ eurjchem-11 8 16     SPACE eurjchem-11 8 17 accuracy accuracy NOUN eurjchem-11 8 18     SPACE eurjchem-11 8 19 for for ADP eurjchem-11 8 20     SPACE eurjchem-11 8 21 unknown unknown ADJ eurjchem-11 8 22     SPACE eurjchem-11 8 23 impurities impurity NOUN eurjchem-11 8 24     SPACE eurjchem-11 8 25 and and CCONJ eurjchem-11 8 26     SPACE eurjchem-11 8 27 their their PRON eurjchem-11 8 28     SPACE eurjchem-11 8 29 fragment fragment NOUN eurjchem-11 8 30     SPACE eurjchem-11 8 31 ions ion NOUN eurjchem-11 8 32     SPACE eurjchem-11 8 33 to to PART eurjchem-11 8 34     SPACE eurjchem-11 8 35 explore explore VERB eurjchem-11 8 36     SPACE eurjchem-11 8 37 the the DET eurjchem-11 8 38     SPACE eurjchem-11 8 39 elemental elemental ADJ eurjchem-11 8 40     SPACE eurjchem-11 8 41 composition composition NOUN eurjchem-11 8 42 . . PUNCT eurjchem-11 8 43     SPACE eurjchem-11 9 1 based base VERB eurjchem-11 9 2     SPACE eurjchem-11 9 3 on on ADP eurjchem-11 9 4     SPACE eurjchem-11 9 5 the the DET eurjchem-11 9 6     SPACE eurjchem-11 9 7 fragmentation fragmentation NOUN eurjchem-11 9 8     SPACE eurjchem-11 9 9 pattern pattern NOUN eurjchem-11 9 10 , , PUNCT eurjchem-11 9 11     SPACE eurjchem-11 9 12 the the DET eurjchem-11 9 13     SPACE eurjchem-11 9 14 possible possible ADJ eurjchem-11 9 15     SPACE eurjchem-11 9 16 structures structure NOUN eurjchem-11 9 17     SPACE eurjchem-11 9 18 of of ADP eurjchem-11 9 19     SPACE eurjchem-11 9 20 the the DET eurjchem-11 9 21     SPACE eurjchem-11 9 22 unknown unknown ADJ eurjchem-11 9 23     SPACE eurjchem-11 9 24 impurities impurity NOUN eurjchem-11 9 25     SPACE eurjchem-11 9 26 were be AUX eurjchem-11 9 27     SPACE eurjchem-11 9 28 proposed propose VERB eurjchem-11 9 29 . . PUNCT eurjchem-11 9 30     SPACE eurjchem-11 9 31 to to ADP eurjchem-11 9 32     SPACE eurjchem-11 9 33 the the DET eurjchem-11 9 34     SPACE eurjchem-11 9 35 best good ADJ eurjchem-11 9 36     SPACE eurjchem-11 9 37 of of ADP eurjchem-11 9 38     SPACE eurjchem-11 9 39 our our PRON eurjchem-11 9 40     SPACE eurjchem-11 9 41 knowledge knowledge NOUN eurjchem-11 9 42 , , PUNCT eurjchem-11 9 43     SPACE eurjchem-11 9 44 there there PRON eurjchem-11 9 45     SPACE eurjchem-11 9 46 were be AUX eurjchem-11 9 47     SPACE eurjchem-11 9 48 no no DET eurjchem-11 9 49     SPACE eurjchem-11 9 50 methods method NOUN eurjchem-11 9 51     SPACE eurjchem-11 9 52 available available ADJ eurjchem-11 9 53     SPACE eurjchem-11 9 54 to to PART eurjchem-11 9 55     SPACE eurjchem-11 9 56 identify identify VERB eurjchem-11 9 57     SPACE eurjchem-11 9 58 the the DET eurjchem-11 9 59     SPACE eurjchem-11 9 60 impurities impurity NOUN eurjchem-11 9 61     SPACE eurjchem-11 9 62 during during ADP eurjchem-11 9 63     SPACE eurjchem-11 9 64 degradation degradation NOUN eurjchem-11 9 65     SPACE eurjchem-11 9 66 of of ADP eurjchem-11 9 67     SPACE eurjchem-11 9 68 aripiprazole aripiprazole NOUN eurjchem-11 9 69     SPACE eurjchem-11 9 70 tablets tablet NOUN eurjchem-11 9 71     SPACE eurjchem-11 9 72 by by ADP eurjchem-11 9 73     SPACE eurjchem-11 9 74 liquid liquid NOUN eurjchem-11 9 75     SPACE eurjchem-11 9 76 chromatography‐mass chromatography‐mass NOUN eurjchem-11 9 77     SPACE eurjchem-11 9 78 spectrometry spectrometry NOUN eurjchem-11 9 79 . . PUNCT eurjchem-11 9 80     SPACE eurjchem-11 9 81 aripiprazole aripiprazole PROPN eurjchem-11 9 82     SPACE eurjchem-11 9 83 identification identification NOUN eurjchem-11 9 84     SPACE eurjchem-11 9 85 of of ADP eurjchem-11 9 86     SPACE eurjchem-11 9 87 degradation degradation NOUN eurjchem-11 9 88     SPACE eurjchem-11 9 89 impurities impurity NOUN eurjchem-11 9 90     SPACE eurjchem-11 9 91 lc‐qtof‐ms lc‐qtof‐ms PROPN eurjchem-11 9 92     SPACE eurjchem-11 9 93 hplc hplc NOUN eurjchem-11 9 94         SPACE eurjchem-11 9 95 1 1 NUM eurjchem-11 9 96 . . PUNCT eurjchem-11 9 97     SPACE eurjchem-11 9 98 introduction introduction NOUN eurjchem-11 9 99         SPACE eurjchem-11 9 100 aripiprazole aripiprazole NOUN eurjchem-11 9 101     SPACE eurjchem-11 9 102 is be AUX eurjchem-11 9 103     SPACE eurjchem-11 9 104 chemically chemically ADV eurjchem-11 9 105     SPACE eurjchem-11 9 106 named name VERB eurjchem-11 9 107     SPACE eurjchem-11 9 108 as as ADP eurjchem-11 9 109     SPACE eurjchem-11 9 110 7‐[4‐[4‐(2,3‐ 7‐[4‐[4‐(2,3‐ NUM eurjchem-11 9 111 dichlorophenyl)piperazin‐1‐yl]butoxy]‐3,4‐dihydro‐1h‐ dichlorophenyl)piperazin‐1‐yl]butoxy]‐3,4‐dihydro‐1h‐ PROPN eurjchem-11 9 112 quinolin‐2‐one quinolin‐2‐one PROPN eurjchem-11 9 113 . . PUNCT eurjchem-11 9 114     SPACE eurjchem-11 10 1 it it PRON eurjchem-11 10 2     SPACE eurjchem-11 10 3 is be AUX eurjchem-11 10 4     SPACE eurjchem-11 10 5 a a DET eurjchem-11 10 6     SPACE eurjchem-11 10 7 novel novel NOUN eurjchem-11 10 8     SPACE eurjchem-11 10 9 and and CCONJ eurjchem-11 10 10     SPACE eurjchem-11 10 11 a a DET eurjchem-11 10 12     SPACE eurjchem-11 10 13 typical typical ADJ eurjchem-11 10 14     SPACE eurjchem-11 10 15 drug drug NOUN eurjchem-11 10 16     SPACE eurjchem-11 10 17 used use VERB eurjchem-11 10 18     SPACE eurjchem-11 10 19 for for ADP eurjchem-11 10 20     SPACE eurjchem-11 10 21 the the DET eurjchem-11 10 22     SPACE eurjchem-11 10 23 treatment treatment NOUN eurjchem-11 10 24     SPACE eurjchem-11 10 25 of of ADP eurjchem-11 10 26     SPACE eurjchem-11 10 27 schizophrenia schizophrenia NOUN eurjchem-11 10 28     SPACE eurjchem-11 10 29 which which PRON eurjchem-11 10 30     SPACE eurjchem-11 10 31 is be AUX eurjchem-11 10 32     SPACE eurjchem-11 10 33 the the DET eurjchem-11 10 34     SPACE eurjchem-11 10 35 common common ADJ eurjchem-11 10 36     SPACE eurjchem-11 10 37 and and CCONJ eurjchem-11 10 38     SPACE eurjchem-11 10 39 well well ADV eurjchem-11 10 40     SPACE eurjchem-11 10 41 recognized recognize VERB eurjchem-11 10 42     SPACE eurjchem-11 10 43 psychiatric psychiatric ADJ eurjchem-11 10 44     SPACE eurjchem-11 10 45 disorder disorder NOUN eurjchem-11 10 46 , , PUNCT eurjchem-11 10 47     SPACE eurjchem-11 10 48 stimulated stimulate VERB eurjchem-11 10 49     SPACE eurjchem-11 10 50 by by ADP eurjchem-11 10 51     SPACE eurjchem-11 10 52 inordinate inordinate VERB eurjchem-11 10 53     SPACE eurjchem-11 10 54 neurotransmission neurotransmission NOUN eurjchem-11 10 55     SPACE eurjchem-11 10 56 action action NOUN eurjchem-11 10 57     SPACE eurjchem-11 10 58 of of ADP eurjchem-11 10 59     SPACE eurjchem-11 10 60 the the DET eurjchem-11 10 61     SPACE eurjchem-11 10 62 dopaminergic dopaminergic ADJ eurjchem-11 10 63     SPACE eurjchem-11 10 64 nervous nervous ADJ eurjchem-11 10 65     SPACE eurjchem-11 10 66 system system NOUN eurjchem-11 10 67     SPACE eurjchem-11 10 68 in in ADP eurjchem-11 10 69     SPACE eurjchem-11 10 70 the the DET eurjchem-11 10 71     SPACE eurjchem-11 10 72 central central ADJ eurjchem-11 10 73     SPACE eurjchem-11 10 74 nervous nervous ADJ eurjchem-11 10 75     SPACE eurjchem-11 10 76 system system NOUN eurjchem-11 10 77     SPACE eurjchem-11 11 1 [ [ X eurjchem-11 11 2 1 1 NUM eurjchem-11 11 3 ] ] PUNCT eurjchem-11 11 4 . . PUNCT eurjchem-11 11 5     SPACE eurjchem-11 11 6 aripiprazole aripiprazole NOUN eurjchem-11 11 7     SPACE eurjchem-11 11 8 is be AUX eurjchem-11 11 9     SPACE eurjchem-11 11 10 a a DET eurjchem-11 11 11     SPACE eurjchem-11 11 12 selective selective ADJ eurjchem-11 11 13     SPACE eurjchem-11 11 14 monoaminergic monoaminergic ADJ eurjchem-11 11 15     SPACE eurjchem-11 11 16 antagonist antagonist NOUN eurjchem-11 11 17     SPACE eurjchem-11 11 18 with with ADP eurjchem-11 11 19     SPACE eurjchem-11 11 20 high high ADJ eurjchem-11 11 21     SPACE eurjchem-11 11 22 affinity affinity NOUN eurjchem-11 11 23     SPACE eurjchem-11 11 24 for for ADP eurjchem-11 11 25     SPACE eurjchem-11 11 26 the the DET eurjchem-11 11 27     SPACE eurjchem-11 11 28 serotonin serotonin NOUN eurjchem-11 11 29     SPACE eurjchem-11 11 30 type type NOUN eurjchem-11 11 31     SPACE eurjchem-11 11 32 2 2 NUM eurjchem-11 11 33     SPACE eurjchem-11 11 34 ( ( PUNCT eurjchem-11 11 35 5ht2 5ht2 NUM eurjchem-11 11 36 ) ) PUNCT eurjchem-11 11 37 , , PUNCT eurjchem-11 11 38     SPACE eurjchem-11 11 39 dopamine dopamine NOUN eurjchem-11 11 40     SPACE eurjchem-11 11 41 type type NOUN eurjchem-11 11 42     SPACE eurjchem-11 11 43 2 2 NUM eurjchem-11 11 44     SPACE eurjchem-11 11 45 ( ( PUNCT eurjchem-11 11 46 d2 d2 PROPN eurjchem-11 11 47 ) ) PUNCT eurjchem-11 11 48     SPACE eurjchem-11 12 1 [ [ X eurjchem-11 12 2 2 2 NUM eurjchem-11 12 3 ] ] PUNCT eurjchem-11 12 4 , , PUNCT eurjchem-11 12 5     SPACE eurjchem-11 12 6 1 1 NUM eurjchem-11 12 7     SPACE eurjchem-11 12 8 and and CCONJ eurjchem-11 12 9     SPACE eurjchem-11 12 10 2 2 NUM eurjchem-11 12 11     SPACE eurjchem-11 12 12 adrenergic adrenergic NOUN eurjchem-11 12 13     SPACE eurjchem-11 12 14 and and CCONJ eurjchem-11 12 15     SPACE eurjchem-11 12 16 h1 h1 NOUN eurjchem-11 12 17     SPACE eurjchem-11 12 18 histaminergic histaminergic ADJ eurjchem-11 12 19     SPACE eurjchem-11 12 20 receptors receptor NOUN eurjchem-11 12 21     SPACE eurjchem-11 13 1 [ [ X eurjchem-11 13 2 3,4 3,4 NUM eurjchem-11 13 3 ] ] PUNCT eurjchem-11 13 4 . . PUNCT eurjchem-11 13 5     SPACE eurjchem-11 14 1 it it PRON eurjchem-11 14 2     SPACE eurjchem-11 14 3 acts act VERB eurjchem-11 14 4     SPACE eurjchem-11 14 5 as as ADP eurjchem-11 14 6     SPACE eurjchem-11 14 7 an an DET eurjchem-11 14 8     SPACE eurjchem-11 14 9 antagonist antagonist NOUN eurjchem-11 14 10     SPACE eurjchem-11 14 11 at at ADP eurjchem-11 14 12     SPACE eurjchem-11 14 13 other other ADJ eurjchem-11 14 14     SPACE eurjchem-11 14 15 receptors receptor NOUN eurjchem-11 14 16     SPACE eurjchem-11 14 17 but but CCONJ eurjchem-11 14 18     SPACE eurjchem-11 14 19 with with ADP eurjchem-11 14 20     SPACE eurjchem-11 14 21 lower low ADJ eurjchem-11 14 22     SPACE eurjchem-11 14 23 potency potency NOUN eurjchem-11 14 24 . . PUNCT eurjchem-11 14 25     SPACE eurjchem-11 15 1 antagonism antagonism NOUN eurjchem-11 15 2     SPACE eurjchem-11 15 3 at at ADP eurjchem-11 15 4     SPACE eurjchem-11 15 5 receptors receptor NOUN eurjchem-11 15 6     SPACE eurjchem-11 15 7 other other ADJ eurjchem-11 15 8     SPACE eurjchem-11 15 9 than than ADP eurjchem-11 15 10     SPACE eurjchem-11 15 11 dopamine dopamine NOUN eurjchem-11 15 12     SPACE eurjchem-11 15 13 and and CCONJ eurjchem-11 15 14     SPACE eurjchem-11 15 15 5ht2 5ht2 NUM eurjchem-11 15 16     SPACE eurjchem-11 15 17 with with ADP eurjchem-11 15 18     SPACE eurjchem-11 15 19 similar similar ADJ eurjchem-11 15 20     SPACE eurjchem-11 15 21 receptor receptor NOUN eurjchem-11 15 22     SPACE eurjchem-11 15 23 affinities affinity NOUN eurjchem-11 15 24     SPACE eurjchem-11 15 25 may may AUX eurjchem-11 15 26     SPACE eurjchem-11 15 27 explain explain VERB eurjchem-11 15 28     SPACE eurjchem-11 15 29 some some PRON eurjchem-11 15 30     SPACE eurjchem-11 15 31 of of ADP eurjchem-11 15 32     SPACE eurjchem-11 15 33 the the DET eurjchem-11 15 34     SPACE eurjchem-11 15 35 other other ADJ eurjchem-11 15 36     SPACE eurjchem-11 15 37 therapeutic therapeutic ADJ eurjchem-11 15 38     SPACE eurjchem-11 15 39 and and CCONJ eurjchem-11 15 40     SPACE eurjchem-11 15 41 side side NOUN eurjchem-11 15 42     SPACE eurjchem-11 15 43 effects effect NOUN eurjchem-11 15 44     SPACE eurjchem-11 15 45 of of ADP eurjchem-11 15 46     SPACE eurjchem-11 15 47 aripiprazole aripiprazole NOUN eurjchem-11 15 48 . . PUNCT eurjchem-11 15 49     SPACE eurjchem-11 16 1 it it PRON eurjchem-11 16 2     SPACE eurjchem-11 16 3 has have AUX eurjchem-11 16 4     SPACE eurjchem-11 16 5 been be AUX eurjchem-11 16 6     SPACE eurjchem-11 16 7 proved prove VERB eurjchem-11 16 8     SPACE eurjchem-11 16 9 that that SCONJ eurjchem-11 16 10     SPACE eurjchem-11 16 11 the the DET eurjchem-11 16 12     SPACE eurjchem-11 16 13 aripiprazole aripiprazole NOUN eurjchem-11 16 14     SPACE eurjchem-11 16 15 can can AUX eurjchem-11 16 16     SPACE eurjchem-11 16 17 improve improve VERB eurjchem-11 16 18     SPACE eurjchem-11 16 19 both both PRON eurjchem-11 16 20     SPACE eurjchem-11 16 21 positive positive ADJ eurjchem-11 16 22     SPACE eurjchem-11 16 23 and and CCONJ eurjchem-11 16 24     SPACE eurjchem-11 16 25 negative negative ADJ eurjchem-11 16 26     SPACE eurjchem-11 16 27 symptoms symptom NOUN eurjchem-11 16 28     SPACE eurjchem-11 16 29 in in ADP eurjchem-11 16 30     SPACE eurjchem-11 16 31 patients patient NOUN eurjchem-11 16 32     SPACE eurjchem-11 16 33 with with ADP eurjchem-11 16 34     SPACE eurjchem-11 16 35 schizophrenia schizophrenia NOUN eurjchem-11 16 36     SPACE eurjchem-11 16 37 and and CCONJ eurjchem-11 16 38     SPACE eurjchem-11 16 39 schizoaffective schizoaffective ADJ eurjchem-11 16 40     SPACE eurjchem-11 16 41 disorder disorder NOUN eurjchem-11 16 42     SPACE eurjchem-11 16 43 in in ADP eurjchem-11 16 44     SPACE eurjchem-11 16 45 clinical clinical ADJ eurjchem-11 16 46     SPACE eurjchem-11 16 47 studies study NOUN eurjchem-11 16 48     SPACE eurjchem-11 17 1 [ [ X eurjchem-11 17 2 5‐7 5‐7 PROPN eurjchem-11 17 3 ] ] X eurjchem-11 17 4 . . PUNCT eurjchem-11 17 5     SPACE eurjchem-11 18 1 in in ADP eurjchem-11 18 2     SPACE eurjchem-11 18 3 pharmaceutical pharmaceutical NOUN eurjchem-11 18 4     SPACE eurjchem-11 18 5 industry industry NOUN eurjchem-11 18 6 , , PUNCT eurjchem-11 18 7     SPACE eurjchem-11 18 8 drug drug NOUN eurjchem-11 18 9     SPACE eurjchem-11 18 10 development development NOUN eurjchem-11 18 11     SPACE eurjchem-11 18 12 demands demand VERB eurjchem-11 18 13     SPACE eurjchem-11 18 14 several several ADJ eurjchem-11 18 15     SPACE eurjchem-11 18 16 physical physical NOUN eurjchem-11 18 17     SPACE eurjchem-11 18 18 and and CCONJ eurjchem-11 18 19     SPACE eurjchem-11 18 20 chemical chemical NOUN eurjchem-11 18 21     SPACE eurjchem-11 18 22 properties property NOUN eurjchem-11 18 23     SPACE eurjchem-11 18 24 to to PART eurjchem-11 18 25     SPACE eurjchem-11 18 26 be be AUX eurjchem-11 18 27     SPACE eurjchem-11 18 28 evaluated evaluate VERB eurjchem-11 18 29     SPACE eurjchem-11 18 30 in in ADP eurjchem-11 18 31     SPACE eurjchem-11 18 32 the the DET eurjchem-11 18 33     SPACE eurjchem-11 18 34 drug drug NOUN eurjchem-11 18 35     SPACE eurjchem-11 18 36 substance substance NOUN eurjchem-11 18 37     SPACE eurjchem-11 18 38 and and CCONJ eurjchem-11 18 39     SPACE eurjchem-11 18 40 formulations formulation NOUN eurjchem-11 18 41     SPACE eurjchem-11 18 42 to to PART eurjchem-11 18 43     SPACE eurjchem-11 18 44 satisfy satisfy VERB eurjchem-11 18 45     SPACE eurjchem-11 18 46 the the DET eurjchem-11 18 47     SPACE eurjchem-11 18 48 fda fda PROPN eurjchem-11 18 49     SPACE eurjchem-11 18 50 and and CCONJ eurjchem-11 18 51     SPACE eurjchem-11 18 52 ich ich NOUN eurjchem-11 18 53     SPACE eurjchem-11 18 54 regulations regulation NOUN eurjchem-11 18 55     SPACE eurjchem-11 19 1 [ [ X eurjchem-11 19 2 8,9 8,9 NUM eurjchem-11 19 3 ] ] PUNCT eurjchem-11 19 4 . . PUNCT eurjchem-11 19 5     SPACE eurjchem-11 20 1 among among ADP eurjchem-11 20 2     SPACE eurjchem-11 20 3 those those DET eurjchem-11 20 4     SPACE eurjchem-11 20 5 properties property NOUN eurjchem-11 20 6 , , PUNCT eurjchem-11 20 7     SPACE eurjchem-11 20 8 stability stability NOUN eurjchem-11 20 9     SPACE eurjchem-11 20 10 of of ADP eurjchem-11 20 11     SPACE eurjchem-11 20 12 the the DET eurjchem-11 20 13     SPACE eurjchem-11 20 14 new new ADJ eurjchem-11 20 15     SPACE eurjchem-11 20 16 drug drug NOUN eurjchem-11 20 17     SPACE eurjchem-11 20 18 is be AUX eurjchem-11 20 19     SPACE eurjchem-11 20 20 a a DET eurjchem-11 20 21     SPACE eurjchem-11 20 22 significant significant ADJ eurjchem-11 20 23     SPACE eurjchem-11 20 24 factor factor NOUN eurjchem-11 20 25 , , PUNCT eurjchem-11 20 26     SPACE eurjchem-11 20 27 requiring require VERB eurjchem-11 20 28     SPACE eurjchem-11 20 29 elaborated elaborate VERB eurjchem-11 20 30     SPACE eurjchem-11 20 31 analysis analysis NOUN eurjchem-11 20 32     SPACE eurjchem-11 20 33 of of ADP eurjchem-11 20 34     SPACE eurjchem-11 20 35 potential potential ADJ eurjchem-11 20 36     SPACE eurjchem-11 20 37 degradation degradation NOUN eurjchem-11 20 38     SPACE eurjchem-11 20 39 products product NOUN eurjchem-11 20 40     SPACE eurjchem-11 20 41 [ [ X eurjchem-11 20 42 10 10 NUM eurjchem-11 20 43 ] ] PUNCT eurjchem-11 20 44 . . PUNCT eurjchem-11 20 45     SPACE eurjchem-11 21 1 the the DET eurjchem-11 21 2     SPACE eurjchem-11 21 3 information information NOUN eurjchem-11 21 4     SPACE eurjchem-11 21 5 regarding regard VERB eurjchem-11 21 6     SPACE eurjchem-11 21 7 degradation degradation NOUN eurjchem-11 21 8     SPACE eurjchem-11 21 9 products product NOUN eurjchem-11 21 10     SPACE eurjchem-11 21 11 is be AUX eurjchem-11 21 12     SPACE eurjchem-11 21 13 commonly commonly ADV eurjchem-11 21 14     SPACE eurjchem-11 21 15 obtained obtain VERB eurjchem-11 21 16     SPACE eurjchem-11 21 17 by by ADP eurjchem-11 21 18     SPACE eurjchem-11 21 19 extended extended ADJ eurjchem-11 21 20     SPACE eurjchem-11 21 21 stability stability NOUN eurjchem-11 21 22     SPACE eurjchem-11 21 23 studies study NOUN eurjchem-11 21 24     SPACE eurjchem-11 21 25 carried carry VERB eurjchem-11 21 26     SPACE eurjchem-11 21 27 out out ADP eurjchem-11 21 28     SPACE eurjchem-11 21 29 under under ADP eurjchem-11 21 30     SPACE eurjchem-11 21 31 different different ADJ eurjchem-11 21 32     SPACE eurjchem-11 21 33 conditions condition NOUN eurjchem-11 21 34 , , PUNCT eurjchem-11 21 35     SPACE eurjchem-11 21 36 such such ADJ eurjchem-11 21 37     SPACE eurjchem-11 21 38 as as ADP eurjchem-11 21 39     SPACE eurjchem-11 21 40 exposure exposure NOUN eurjchem-11 21 41     SPACE eurjchem-11 21 42 to to ADP eurjchem-11 21 43     SPACE eurjchem-11 21 44 adverse adverse ADJ eurjchem-11 21 45     SPACE eurjchem-11 21 46 temperatures temperature NOUN eurjchem-11 21 47 , , PUNCT eurjchem-11 21 48     SPACE eurjchem-11 21 49 hydrolysis hydrolysis NOUN eurjchem-11 21 50 , , PUNCT eurjchem-11 21 51     SPACE eurjchem-11 21 52 ph ph VERB eurjchem-11 21 53 , , PUNCT eurjchem-11 21 54     SPACE eurjchem-11 21 55 humidity humidity NOUN eurjchem-11 21 56 , , PUNCT eurjchem-11 21 57     SPACE eurjchem-11 21 58 oxidation oxidation NOUN eurjchem-11 21 59 , , PUNCT eurjchem-11 21 60     SPACE eurjchem-11 21 61 etc etc X eurjchem-11 21 62 . . X eurjchem-11 21 63     SPACE eurjchem-11 22 1 [ [ X eurjchem-11 22 2 9 9 NUM eurjchem-11 22 3 ] ] PUNCT eurjchem-11 22 4 . . PUNCT eurjchem-11 22 5     SPACE eurjchem-11 22 6 as as ADP eurjchem-11 22 7     SPACE eurjchem-11 22 8 per per ADP eurjchem-11 22 9     SPACE eurjchem-11 22 10 regulatory regulatory ADJ eurjchem-11 22 11     SPACE eurjchem-11 22 12 guidelines guideline NOUN eurjchem-11 22 13 , , PUNCT eurjchem-11 22 14     SPACE eurjchem-11 22 15 the the DET eurjchem-11 22 16     SPACE eurjchem-11 22 17 pharmaceutical pharmaceutical NOUN eurjchem-11 22 18     SPACE eurjchem-11 22 19 studies study NOUN eurjchem-11 22 20     SPACE eurjchem-11 22 21 using use VERB eurjchem-11 22 22     SPACE eurjchem-11 22 23 a a DET eurjchem-11 22 24     SPACE eurjchem-11 22 25 sample sample NOUN eurjchem-11 22 26     SPACE eurjchem-11 22 27 of of ADP eurjchem-11 22 28     SPACE eurjchem-11 22 29 isolated isolate VERB eurjchem-11 22 30     SPACE eurjchem-11 22 31 impurities impurity NOUN eurjchem-11 22 32     SPACE eurjchem-11 22 33 can can AUX eurjchem-11 22 34     SPACE eurjchem-11 22 35 be be AUX eurjchem-11 22 36     SPACE eurjchem-11 22 37 considered consider VERB eurjchem-11 22 38     SPACE eurjchem-11 22 39 for for ADP eurjchem-11 22 40     SPACE eurjchem-11 22 41 safety safety NOUN eurjchem-11 22 42     SPACE eurjchem-11 22 43 assessment assessment NOUN eurjchem-11 22 44 . . PUNCT eurjchem-11 22 45     SPACE eurjchem-11 23 1 it it PRON eurjchem-11 23 2     SPACE eurjchem-11 23 3 is be AUX eurjchem-11 23 4 , , PUNCT eurjchem-11 23 5     SPACE eurjchem-11 23 6 therefore therefore ADV eurjchem-11 23 7 , , PUNCT eurjchem-11 23 8     SPACE eurjchem-11 23 9 essential essential ADJ eurjchem-11 23 10     SPACE eurjchem-11 23 11 to to PART eurjchem-11 23 12     SPACE eurjchem-11 23 13 isolate isolate VERB eurjchem-11 23 14     SPACE eurjchem-11 23 15 and and CCONJ eurjchem-11 23 16     SPACE eurjchem-11 23 17 characterize characterize VERB eurjchem-11 23 18     SPACE eurjchem-11 23 19 the the DET eurjchem-11 23 20     SPACE eurjchem-11 23 21 un‐identified un‐identified ADJ eurjchem-11 23 22     SPACE eurjchem-11 23 23 impurities impurity NOUN eurjchem-11 23 24     SPACE eurjchem-11 23 25 present present ADJ eurjchem-11 23 26     SPACE eurjchem-11 23 27 in in ADP eurjchem-11 23 28     SPACE eurjchem-11 23 29 the the DET eurjchem-11 23 30     SPACE eurjchem-11 23 31 drug drug NOUN eurjchem-11 23 32     SPACE eurjchem-11 23 33 sample sample NOUN eurjchem-11 23 34 . . PUNCT eurjchem-11 23 35     SPACE eurjchem-11 24 1 so so ADV eurjchem-11 24 2 , , PUNCT eurjchem-11 24 3     SPACE eurjchem-11 24 4 structural structural ADJ eurjchem-11 24 5     SPACE eurjchem-11 24 6 elucidation elucidation NOUN eurjchem-11 24 7     SPACE eurjchem-11 24 8 of of ADP eurjchem-11 24 9     SPACE eurjchem-11 24 10 unknown unknown ADJ eurjchem-11 24 11     SPACE eurjchem-11 24 12 impurities impurity NOUN eurjchem-11 24 13     SPACE eurjchem-11 24 14 is be AUX eurjchem-11 24 15     SPACE eurjchem-11 24 16 an an DET eurjchem-11 24 17     SPACE eurjchem-11 24 18 analytical analytical ADJ eurjchem-11 24 19     SPACE eurjchem-11 24 20 challenge challenge NOUN eurjchem-11 24 21     SPACE eurjchem-11 24 22 that that PRON eurjchem-11 24 23     SPACE eurjchem-11 24 24 requires require VERB eurjchem-11 24 25     SPACE eurjchem-11 24 26 both both PRON eurjchem-11 24 27     SPACE eurjchem-11 24 28 selective selective NOUN eurjchem-11 24 29     SPACE eurjchem-11 24 30 and and CCONJ eurjchem-11 24 31     SPACE eurjchem-11 24 32 sensitive sensitive ADJ eurjchem-11 24 33     SPACE eurjchem-11 24 34 methods method NOUN eurjchem-11 24 35     SPACE eurjchem-11 25 1 [ [ X eurjchem-11 25 2 11,12 11,12 NUM eurjchem-11 25 3 ] ] PUNCT eurjchem-11 25 4 . . PUNCT eurjchem-11 25 5     SPACE eurjchem-11 26 1 different different ADJ eurjchem-11 26 2     SPACE eurjchem-11 26 3 analytical analytical ADJ eurjchem-11 26 4     SPACE eurjchem-11 26 5 techniques technique NOUN eurjchem-11 26 6     SPACE eurjchem-11 26 7 have have AUX eurjchem-11 26 8     SPACE eurjchem-11 26 9 been be AUX eurjchem-11 26 10     SPACE eurjchem-11 26 11 reported report VERB eurjchem-11 26 12     SPACE eurjchem-11 26 13 for for ADP eurjchem-11 26 14     SPACE eurjchem-11 26 15 the the DET eurjchem-11 26 16     SPACE eurjchem-11 26 17 determination determination NOUN eurjchem-11 26 18     SPACE eurjchem-11 26 19 of of ADP eurjchem-11 26 20     SPACE eurjchem-11 26 21 aripiprazole aripiprazole NOUN eurjchem-11 26 22     SPACE eurjchem-11 26 23 and and CCONJ eurjchem-11 26 24     SPACE eurjchem-11 26 25 its its PRON eurjchem-11 26 26     SPACE eurjchem-11 26 27 metabolites metabolite NOUN eurjchem-11 26 28     SPACE eurjchem-11 26 29 in in ADP eurjchem-11 26 30     SPACE eurjchem-11 26 31 human human ADJ eurjchem-11 26 32     SPACE eurjchem-11 26 33 plasma plasma NOUN eurjchem-11 26 34     SPACE eurjchem-11 26 35 by by ADP eurjchem-11 26 36     SPACE eurjchem-11 26 37 liquid liquid NOUN eurjchem-11 26 38     SPACE eurjchem-11 26 39 chromatography‐mass chromatography‐mass NOUN eurjchem-11 26 40     SPACE eurjchem-11 26 41 spectrometry spectrometry NOUN eurjchem-11 26 42     SPACE eurjchem-11 26 43 ( ( PUNCT eurjchem-11 26 44 lc lc PROPN eurjchem-11 26 45 – – PUNCT eurjchem-11 26 46 ms ms NOUN eurjchem-11 26 47 ) ) PUNCT eurjchem-11 26 48     SPACE eurjchem-11 27 1 [ [ X eurjchem-11 27 2 13,14 13,14 NUM eurjchem-11 27 3 ] ] X eurjchem-11 27 4 , , PUNCT eurjchem-11 27 5     SPACE eurjchem-11 27 6 in in ADP eurjchem-11 27 7     SPACE eurjchem-11 27 8 blood blood NOUN eurjchem-11 27 9     SPACE eurjchem-11 27 10 samples sample NOUN eurjchem-11 27 11     SPACE eurjchem-11 27 12 of of ADP eurjchem-11 27 13     SPACE eurjchem-11 27 14 psychiatric psychiatric ADJ eurjchem-11 27 15     SPACE eurjchem-11 27 16 patients patient NOUN eurjchem-11 27 17     SPACE eurjchem-11 27 18 by by ADP eurjchem-11 27 19     SPACE eurjchem-11 27 20 gas gas NOUN eurjchem-11 27 21     SPACE eurjchem-11 27 22 chromatography chromatography NOUN eurjchem-11 27 23 – – PUNCT eurjchem-11 27 24 mass mass ADJ eurjchem-11 27 25     SPACE eurjchem-11 27 26 spectrometry spectrometry NOUN eurjchem-11 27 27     SPACE eurjchem-11 27 28 ( ( PUNCT eurjchem-11 27 29 gc‐ms gc‐ms NOUN eurjchem-11 27 30 ) ) PUNCT eurjchem-11 27 31     SPACE eurjchem-11 28 1 [ [ X eurjchem-11 28 2 15 15 NUM eurjchem-11 28 3 ] ] SYM eurjchem-11 28 4     SPACE eurjchem-11 28 5 and and CCONJ eurjchem-11 28 6     SPACE eurjchem-11 28 7 in in ADP eurjchem-11 28 8     SPACE eurjchem-11 28 9 pharmaceutical pharmaceutical NOUN eurjchem-11 28 10     SPACE eurjchem-11 28 11 dosage dosage NOUN eurjchem-11 28 12     SPACE eurjchem-11 28 13 forms form NOUN eurjchem-11 28 14     SPACE eurjchem-11 28 15 by by ADP eurjchem-11 28 16     SPACE eurjchem-11 28 17 liquid liquid NOUN eurjchem-11 28 18     SPACE eurjchem-11 28 19 chromatography chromatography NOUN eurjchem-11 28 20     SPACE eurjchem-11 28 21 ( ( PUNCT eurjchem-11 28 22 lc lc PROPN eurjchem-11 28 23 ) ) PUNCT eurjchem-11 28 24     SPACE eurjchem-11 28 25 [ [ X eurjchem-11 28 26 16 16 NUM eurjchem-11 28 27 ] ] PUNCT eurjchem-11 28 28 . . PUNCT eurjchem-11 28 29     SPACE eurjchem-11 28 30 zha zha PROPN eurjchem-11 28 31     SPACE eurjchem-11 28 32 et et PROPN eurjchem-11 28 33     SPACE eurjchem-11 28 34 al al PROPN eurjchem-11 28 35 . . PROPN eurjchem-11 28 36     SPACE eurjchem-11 28 37 described describe VERB eurjchem-11 28 38     SPACE eurjchem-11 28 39 a a DET eurjchem-11 28 40     SPACE eurjchem-11 28 41 lc lc NOUN eurjchem-11 28 42     SPACE eurjchem-11 28 43 method method NOUN eurjchem-11 28 44     SPACE eurjchem-11 28 45 for for ADP eurjchem-11 28 46     SPACE eurjchem-11 28 47 separation separation NOUN eurjchem-11 28 48     SPACE eurjchem-11 28 49 of of ADP eurjchem-11 28 50     SPACE eurjchem-11 28 51 impurities impurity NOUN eurjchem-11 28 52     SPACE eurjchem-11 28 53 related relate VERB eurjchem-11 28 54     SPACE eurjchem-11 28 55 to to ADP eurjchem-11 28 56     SPACE eurjchem-11 28 57 aripiprazole aripiprazole NOUN eurjchem-11 28 58     SPACE eurjchem-11 29 1 [ [ X eurjchem-11 29 2 17 17 NUM eurjchem-11 29 3 ] ] SYM eurjchem-11 29 4     SPACE eurjchem-11 29 5 and and CCONJ eurjchem-11 29 6     SPACE eurjchem-11 29 7 sreenivas sreenivas NOUN eurjchem-11 29 8     SPACE eurjchem-11 29 9 et et PROPN eurjchem-11 29 10     SPACE eurjchem-11 29 11 al al PROPN eurjchem-11 29 12 . . PROPN eurjchem-11 29 13     SPACE eurjchem-11 29 14 reported report VERB eurjchem-11 29 15     SPACE eurjchem-11 29 16 degradation degradation NOUN eurjchem-11 29 17     SPACE eurjchem-11 29 18 study study NOUN eurjchem-11 29 19     SPACE eurjchem-11 29 20 of of ADP eurjchem-11 29 21     SPACE eurjchem-11 29 22 aripiprazole aripiprazole NOUN eurjchem-11 29 23     SPACE eurjchem-11 29 24 drug drug NOUN eurjchem-11 29 25     SPACE eurjchem-11 29 26 substance substance NOUN eurjchem-11 29 27     SPACE eurjchem-11 29 28 ( ( PUNCT eurjchem-11 29 29 active active ADJ eurjchem-11 29 30     SPACE eurjchem-11 29 31 pharmaceutical pharmaceutical NOUN eurjchem-11 29 32     SPACE eurjchem-11 29 33 ingredient ingredient NOUN eurjchem-11 29 34 ) ) PUNCT eurjchem-11 29 35     SPACE eurjchem-11 29 36 using use VERB eurjchem-11 29 37     SPACE eurjchem-11 29 38 lc lc PROPN eurjchem-11 29 39     SPACE eurjchem-11 29 40 [ [ X eurjchem-11 29 41 18 18 NUM eurjchem-11 29 42 ] ] PUNCT eurjchem-11 29 43 . . PUNCT eurjchem-11 29 44       SPACE eurjchem-11 29 45 until until ADP eurjchem-11 29 46     SPACE eurjchem-11 29 47 today today NOUN eurjchem-11 29 48 , , PUNCT eurjchem-11 29 49     SPACE eurjchem-11 29 50 no no DET eurjchem-11 29 51     SPACE eurjchem-11 29 52 degradation degradation NOUN eurjchem-11 29 53     SPACE eurjchem-11 29 54 study study NOUN eurjchem-11 29 55     SPACE eurjchem-11 29 56 was be AUX eurjchem-11 29 57     SPACE eurjchem-11 29 58 available available ADJ eurjchem-11 29 59     SPACE eurjchem-11 29 60 on on ADP eurjchem-11 29 61     SPACE eurjchem-11 29 62 aripiprazole aripiprazole NOUN eurjchem-11 29 63     SPACE eurjchem-11 29 64 using use VERB eurjchem-11 29 65     SPACE eurjchem-11 29 66 liquid liquid NOUN eurjchem-11 29 67     SPACE eurjchem-11 29 68 chromatography‐mass chromatography‐mass NOUN eurjchem-11 29 69     SPACE eurjchem-11 29 70 spectrometry spectrometry NOUN eurjchem-11 29 71     SPACE eurjchem-11 29 72 ( ( PUNCT eurjchem-11 29 73 lc‐ms lc‐ms NUM eurjchem-11 29 74 ) ) PUNCT eurjchem-11 29 75 . . PUNCT eurjchem-11 29 76     SPACE eurjchem-11 29 77 in in ADP eurjchem-11 29 78     SPACE eurjchem-11 29 79 the the DET eurjchem-11 29 80     SPACE eurjchem-11 29 81 present present ADJ eurjchem-11 29 82     SPACE eurjchem-11 29 83 work work NOUN eurjchem-11 29 84 , , PUNCT eurjchem-11 29 85     SPACE eurjchem-11 29 86 degradation degradation NOUN eurjchem-11 29 87     SPACE eurjchem-11 29 88 studies study NOUN eurjchem-11 29 89     SPACE eurjchem-11 29 90 of of ADP eurjchem-11 29 91     SPACE eurjchem-11 29 92 aripiprazole aripiprazole NOUN eurjchem-11 29 93     SPACE eurjchem-11 29 94 drug drug NOUN eurjchem-11 29 95     SPACE eurjchem-11 29 96 product product NOUN eurjchem-11 29 97     SPACE eurjchem-11 29 98 including include VERB eurjchem-11 29 99     SPACE eurjchem-11 29 100 thermal thermal ADJ eurjchem-11 29 101 , , PUNCT eurjchem-11 29 102     SPACE eurjchem-11 29 103 oxidation oxidation NOUN eurjchem-11 29 104 , , PUNCT eurjchem-11 29 105     SPACE eurjchem-11 29 106 humidity humidity NOUN eurjchem-11 29 107 , , PUNCT eurjchem-11 29 108     SPACE eurjchem-11 29 109 photolytic photolytic ADJ eurjchem-11 29 110 , , PUNCT eurjchem-11 29 111     SPACE eurjchem-11 29 112 acid acid NOUN eurjchem-11 29 113     SPACE eurjchem-11 29 114 and and CCONJ eurjchem-11 29 115     SPACE eurjchem-11 29 116 base base NOUN eurjchem-11 29 117     SPACE eurjchem-11 29 118 were be AUX eurjchem-11 29 119     SPACE eurjchem-11 29 120 carried carry VERB eurjchem-11 29 121     SPACE eurjchem-11 29 122 out out ADP eurjchem-11 29 123     SPACE eurjchem-11 29 124 using use VERB eurjchem-11 29 125     SPACE eurjchem-11 29 126 lc‐ lc‐ ADJ eurjchem-11 29 127 qtof‐ms qtof‐ms NOUN eurjchem-11 29 128     SPACE eurjchem-11 29 129 to to PART eurjchem-11 29 130     SPACE eurjchem-11 29 131 identify identify VERB eurjchem-11 29 132     SPACE eurjchem-11 29 133 the the DET eurjchem-11 29 134     SPACE eurjchem-11 29 135 degradation degradation NOUN eurjchem-11 29 136     SPACE eurjchem-11 29 137 products product NOUN eurjchem-11 29 138 . . PUNCT eurjchem-11 29 139     SPACE eurjchem-11 30 1 ms ms PROPN eurjchem-11 30 2     SPACE eurjchem-11 30 3 and and CCONJ eurjchem-11 30 4     SPACE eurjchem-11 30 5 ms ms PROPN eurjchem-11 30 6 / / SYM eurjchem-11 30 7 ms ms PROPN eurjchem-11 30 8     SPACE eurjchem-11 30 9 studies study NOUN eurjchem-11 30 10     SPACE eurjchem-11 30 11 were be AUX eurjchem-11 30 12     SPACE eurjchem-11 30 13 implemented implement VERB eurjchem-11 30 14     SPACE eurjchem-11 30 15 for for ADP eurjchem-11 30 16     SPACE eurjchem-11 30 17 these these DET eurjchem-11 30 18     SPACE eurjchem-11 30 19 products product NOUN eurjchem-11 30 20     SPACE eurjchem-11 30 21 using use VERB eurjchem-11 30 22     SPACE eurjchem-11 30 23 qtof qtof PROPN eurjchem-11 30 24     SPACE eurjchem-11 30 25 micromass micromass NOUN eurjchem-11 30 26     SPACE eurjchem-11 30 27 instrument instrument NOUN eurjchem-11 30 28 . . PUNCT eurjchem-11 30 29         SPACE eurjchem-11 31 1 2 2 NUM eurjchem-11 31 2 . . PUNCT eurjchem-11 31 3     SPACE eurjchem-11 31 4 experimental experimental ADJ eurjchem-11 31 5             SPACE eurjchem-11 31 6 2.1 2.1 NUM eurjchem-11 31 7 . . PUNCT eurjchem-11 31 8     SPACE eurjchem-11 31 9 chemicals chemical NOUN eurjchem-11 31 10     SPACE eurjchem-11 31 11 and and CCONJ eurjchem-11 31 12     SPACE eurjchem-11 31 13 reagents reagent NOUN eurjchem-11 31 14         SPACE eurjchem-11 31 15 reference reference NOUN eurjchem-11 31 16     SPACE eurjchem-11 31 17 standard standard NOUN eurjchem-11 31 18     SPACE eurjchem-11 31 19 of of ADP eurjchem-11 31 20     SPACE eurjchem-11 31 21 aripiprazole aripiprazole NOUN eurjchem-11 31 22 , , PUNCT eurjchem-11 31 23     SPACE eurjchem-11 31 24 aripiprazole aripiprazole NOUN eurjchem-11 31 25     SPACE eurjchem-11 31 26 tablets tablet NOUN eurjchem-11 31 27     SPACE eurjchem-11 31 28 and and CCONJ eurjchem-11 31 29     SPACE eurjchem-11 31 30 five five NUM eurjchem-11 31 31     SPACE eurjchem-11 31 32 known know VERB eurjchem-11 31 33     SPACE eurjchem-11 31 34 impurities impurity NOUN eurjchem-11 31 35     SPACE eurjchem-11 31 36 namely namely ADV eurjchem-11 31 37 , , PUNCT eurjchem-11 31 38     SPACE eurjchem-11 31 39 7­hdq 7­hdq NUM eurjchem-11 31 40 : : PUNCT eurjchem-11 31 41     SPACE eurjchem-11 31 42 7‐hydroxy‐3,4‐ 7‐hydroxy‐3,4‐ NUM eurjchem-11 31 43 dihydroquinolin‐2(1h)‐one dihydroquinolin‐2(1h)‐one PROPN eurjchem-11 31 44 . . PUNCT eurjchem-11 31 45     SPACE eurjchem-11 31 46 dcpp dcpp NOUN eurjchem-11 31 47 : : PUNCT eurjchem-11 31 48     SPACE eurjchem-11 31 49 1‐(2,3‐dichlorophenyl)pipe 1‐(2,3‐dichlorophenyl)pipe NUM eurjchem-11 31 50     SPACE eurjchem-11 31 51 razine razine NOUN eurjchem-11 31 52     SPACE eurjchem-11 31 53 hydrochloride hydrochloride NOUN eurjchem-11 31 54 . . PUNCT eurjchem-11 31 55     SPACE eurjchem-11 32 1 apr­i apr­i ADV eurjchem-11 32 2 : : PUNCT eurjchem-11 32 3     SPACE eurjchem-11 32 4 7‐(4‐bromobutoxy)‐3,4‐dihydro 7‐(4‐bromobutoxy)‐3,4‐dihydro NOUN eurjchem-11 32 5     SPACE eurjchem-11 32 6 quinolin‐2(1h)‐one quinolin‐2(1h)‐one NOUN eurjchem-11 32 7 . . PUNCT eurjchem-11 32 8     SPACE eurjchem-11 33 1 imp­b imp­b NUM eurjchem-11 33 2 : : PUNCT eurjchem-11 33 3     SPACE eurjchem-11 33 4 7,7’‐(butylenedioxy)di‐3,4‐dihydro 7,7’‐(butylenedioxy)di‐3,4‐dihydro NUM eurjchem-11 33 5     SPACE eurjchem-11 33 6 quinolin‐2(1h)‐one quinolin‐2(1h)‐one NOUN eurjchem-11 33 7 . . PUNCT eurjchem-11 33 8     SPACE eurjchem-11 34 1 n­bdq n­bdq ADV eurjchem-11 34 2 : : PUNCT eurjchem-11 34 3     SPACE eurjchem-11 34 4 7‐[4‐[4‐(2,3‐dichlorophenyl)pipe 7‐[4‐[4‐(2,3‐dichlorophenyl)pipe NUM eurjchem-11 34 5     SPACE eurjchem-11 34 6 reddy reddy NOUN eurjchem-11 34 7     SPACE eurjchem-11 34 8 et et PROPN eurjchem-11 34 9     SPACE eurjchem-11 34 10 al al PROPN eurjchem-11 34 11 . . PROPN eurjchem-11 34 12     SPACE eurjchem-11 34 13 / / SYM eurjchem-11 34 14     SPACE eurjchem-11 34 15 european european ADJ eurjchem-11 34 16     SPACE eurjchem-11 34 17 journal journal NOUN eurjchem-11 34 18     SPACE eurjchem-11 34 19 of of ADP eurjchem-11 34 20     SPACE eurjchem-11 34 21 chemistry chemistry NOUN eurjchem-11 34 22     SPACE eurjchem-11 34 23 1 1 NUM eurjchem-11 34 24     SPACE eurjchem-11 34 25 ( ( PUNCT eurjchem-11 34 26 1 1 NUM eurjchem-11 34 27 ) ) PUNCT eurjchem-11 34 28     SPACE eurjchem-11 34 29 ( ( PUNCT eurjchem-11 34 30 2010 2010 NUM eurjchem-11 34 31 ) ) PUNCT eurjchem-11 34 32     SPACE eurjchem-11 35 1 20­27 20­27 NUM eurjchem-11 35 2     SPACE eurjchem-11 35 3 21 21 NUM eurjchem-11 35 4     SPACE eurjchem-11 35 5 razin‐1‐yl]butoxy]‐1‐[4‐(2‐oxo‐3,4‐dihydro‐1h‐quinolin‐7‐yl razin‐1‐yl]butoxy]‐1‐[4‐(2‐oxo‐3,4‐dihydro‐1h‐quinolin‐7‐yl PROPN eurjchem-11 35 6 ) ) PUNCT eurjchem-11 35 7     SPACE eurjchem-11 35 8 butoxy]‐3,4‐dihydro‐1h‐quinolin‐2‐one butoxy]‐3,4‐dihydro‐1h‐quinolin‐2‐one SYM eurjchem-11 35 9     SPACE eurjchem-11 35 10 ( ( PUNCT eurjchem-11 35 11 figure figure NOUN eurjchem-11 35 12     SPACE eurjchem-11 35 13 1 1 NUM eurjchem-11 35 14 ) ) PUNCT eurjchem-11 35 15     SPACE eurjchem-11 35 16 were be AUX eurjchem-11 35 17     SPACE eurjchem-11 35 18 obtained obtain VERB eurjchem-11 35 19     SPACE eurjchem-11 35 20 from from ADP eurjchem-11 35 21     SPACE eurjchem-11 35 22 jubilant jubilant ADJ eurjchem-11 35 23     SPACE eurjchem-11 35 24 organosys organosy NOUN eurjchem-11 35 25     SPACE eurjchem-11 35 26 limited limited ADJ eurjchem-11 35 27     SPACE eurjchem-11 35 28 ( ( PUNCT eurjchem-11 35 29 noida noida PROPN eurjchem-11 35 30 , , PUNCT eurjchem-11 35 31     SPACE eurjchem-11 35 32 india india PROPN eurjchem-11 35 33 ) ) PUNCT eurjchem-11 35 34 . . PUNCT eurjchem-11 35 35     SPACE eurjchem-11 36 1 lc‐ lc‐ VERB eurjchem-11 36 2 ms ms ADJ eurjchem-11 36 3     SPACE eurjchem-11 36 4 grade grade NOUN eurjchem-11 36 5     SPACE eurjchem-11 36 6 methanol methanol NOUN eurjchem-11 36 7     SPACE eurjchem-11 36 8 ( ( PUNCT eurjchem-11 36 9 meoh meoh PROPN eurjchem-11 36 10 ) ) PUNCT eurjchem-11 36 11     SPACE eurjchem-11 36 12 and and CCONJ eurjchem-11 36 13     SPACE eurjchem-11 36 14 acetonitrile acetonitrile NOUN eurjchem-11 36 15     SPACE eurjchem-11 36 16 ( ( PUNCT eurjchem-11 36 17 acn acn PROPN eurjchem-11 36 18 ) ) PUNCT eurjchem-11 36 19     SPACE eurjchem-11 36 20 were be AUX eurjchem-11 36 21     SPACE eurjchem-11 36 22 purchased purchase VERB eurjchem-11 36 23     SPACE eurjchem-11 36 24 from from ADP eurjchem-11 36 25     SPACE eurjchem-11 36 26 j. j. PROPN eurjchem-11 36 27     SPACE eurjchem-11 36 28 t. t. PROPN eurjchem-11 36 29     SPACE eurjchem-11 36 30 baker baker PROPN eurjchem-11 36 31     SPACE eurjchem-11 36 32 ( ( PUNCT eurjchem-11 36 33 mexico mexico PROPN eurjchem-11 36 34 , , PUNCT eurjchem-11 36 35     SPACE eurjchem-11 36 36 usa usa PROPN eurjchem-11 36 37 ) ) PUNCT eurjchem-11 36 38 . . PUNCT eurjchem-11 36 39     SPACE eurjchem-11 37 1 analytical analytical ADJ eurjchem-11 37 2     SPACE eurjchem-11 37 3 reagent reagent ADJ eurjchem-11 37 4     SPACE eurjchem-11 37 5 grade grade NOUN eurjchem-11 37 6     SPACE eurjchem-11 37 7 sodium sodium NOUN eurjchem-11 37 8     SPACE eurjchem-11 37 9 hydroxide hydroxide NOUN eurjchem-11 37 10     SPACE eurjchem-11 37 11 was be AUX eurjchem-11 37 12     SPACE eurjchem-11 37 13 purchased purchase VERB eurjchem-11 37 14     SPACE eurjchem-11 37 15 from from ADP eurjchem-11 37 16     SPACE eurjchem-11 37 17 ranchem ranchem NOUN eurjchem-11 37 18     SPACE eurjchem-11 37 19 ( ( PUNCT eurjchem-11 37 20 ranbaxy ranbaxy PROPN eurjchem-11 37 21     SPACE eurjchem-11 37 22 laboratories laboratory NOUN eurjchem-11 37 23     SPACE eurjchem-11 37 24 ltd ltd PROPN eurjchem-11 37 25 , , PUNCT eurjchem-11 37 26     SPACE eurjchem-11 37 27 gurgaon gurgaon PROPN eurjchem-11 37 28 , , PUNCT eurjchem-11 37 29     SPACE eurjchem-11 37 30 india india PROPN eurjchem-11 37 31 ) ) PUNCT eurjchem-11 37 32 . . PUNCT eurjchem-11 37 33     SPACE eurjchem-11 38 1 ultra ultra ADJ eurjchem-11 38 2     SPACE eurjchem-11 38 3 pure pure ADJ eurjchem-11 38 4     SPACE eurjchem-11 38 5 water water NOUN eurjchem-11 38 6     SPACE eurjchem-11 38 7 was be AUX eurjchem-11 38 8     SPACE eurjchem-11 38 9 obtained obtain VERB eurjchem-11 38 10     SPACE eurjchem-11 38 11 from from ADP eurjchem-11 38 12     SPACE eurjchem-11 38 13 a a DET eurjchem-11 38 14     SPACE eurjchem-11 38 15 water water NOUN eurjchem-11 38 16     SPACE eurjchem-11 38 17 purification purification NOUN eurjchem-11 38 18     SPACE eurjchem-11 38 19 unit unit NOUN eurjchem-11 38 20     SPACE eurjchem-11 38 21 ( ( PUNCT eurjchem-11 38 22 elga elga PROPN eurjchem-11 38 23     SPACE eurjchem-11 38 24 ltd ltd PROPN eurjchem-11 38 25 . . PROPN eurjchem-11 38 26 , , PUNCT eurjchem-11 38 27     SPACE eurjchem-11 38 28 england england PROPN eurjchem-11 38 29 ) ) PUNCT eurjchem-11 38 30 . . PUNCT eurjchem-11 38 31     SPACE eurjchem-11 39 1 ammonium ammonium NOUN eurjchem-11 39 2     SPACE eurjchem-11 39 3 acetate acetate NOUN eurjchem-11 39 4     SPACE eurjchem-11 39 5 and and CCONJ eurjchem-11 39 6     SPACE eurjchem-11 39 7 formic formic NOUN eurjchem-11 39 8     SPACE eurjchem-11 39 9 acid acid NOUN eurjchem-11 39 10     SPACE eurjchem-11 39 11 were be AUX eurjchem-11 39 12     SPACE eurjchem-11 39 13 purchased purchase VERB eurjchem-11 39 14     SPACE eurjchem-11 39 15 from from ADP eurjchem-11 39 16     SPACE eurjchem-11 39 17 sigma‐aldrich sigma‐aldrich NOUN eurjchem-11 39 18     SPACE eurjchem-11 39 19 ( ( PUNCT eurjchem-11 39 20 steinheim steinheim PROPN eurjchem-11 39 21 , , PUNCT eurjchem-11 39 22     SPACE eurjchem-11 39 23 germany germany PROPN eurjchem-11 39 24 ) ) PUNCT eurjchem-11 39 25 . . PUNCT eurjchem-11 39 26               SPACE eurjchem-11 40 1 aripirprazole aripirprazole NOUN eurjchem-11 40 2         SPACE eurjchem-11 40 3 7‐hdq 7‐hdq NUM eurjchem-11 40 4         SPACE eurjchem-11 40 5 dcpp dcpp NOUN eurjchem-11 40 6         SPACE eurjchem-11 40 7 imp‐b imp‐b PROPN eurjchem-11 40 8             SPACE eurjchem-11 40 9 apr‐i apr‐i NOUN eurjchem-11 40 10         SPACE eurjchem-11 40 11 n‐bdq n‐bdq PROPN eurjchem-11 40 12         SPACE eurjchem-11 40 13 figure figure NOUN eurjchem-11 40 14     SPACE eurjchem-11 40 15 1 1 NUM eurjchem-11 40 16 . . PUNCT eurjchem-11 40 17     SPACE eurjchem-11 40 18 structures structure NOUN eurjchem-11 40 19     SPACE eurjchem-11 40 20 of of ADP eurjchem-11 40 21     SPACE eurjchem-11 40 22 aripiprazole aripiprazole NOUN eurjchem-11 40 23     SPACE eurjchem-11 40 24 and and CCONJ eurjchem-11 40 25     SPACE eurjchem-11 40 26 its its PRON eurjchem-11 40 27     SPACE eurjchem-11 40 28 known know VERB eurjchem-11 40 29     SPACE eurjchem-11 40 30 impurities impurity NOUN eurjchem-11 40 31         SPACE eurjchem-11 40 32 2.2 2.2 NUM eurjchem-11 40 33 . . PUNCT eurjchem-11 40 34     SPACE eurjchem-11 40 35 equipment equipment NOUN eurjchem-11 40 36           SPACE eurjchem-11 40 37 a a DET eurjchem-11 40 38     SPACE eurjchem-11 40 39 waters water NOUN eurjchem-11 40 40     SPACE eurjchem-11 40 41 hplc hplc NOUN eurjchem-11 40 42     SPACE eurjchem-11 40 43 system system NOUN eurjchem-11 40 44     SPACE eurjchem-11 40 45 of of ADP eurjchem-11 40 46     SPACE eurjchem-11 40 47 alliance alliance NOUN eurjchem-11 40 48     SPACE eurjchem-11 40 49 2695 2695 NUM eurjchem-11 40 50     SPACE eurjchem-11 40 51 ( ( PUNCT eurjchem-11 40 52 milford milford NOUN eurjchem-11 40 53 , , PUNCT eurjchem-11 40 54     SPACE eurjchem-11 40 55 ma ma PROPN eurjchem-11 40 56 , , PUNCT eurjchem-11 40 57     SPACE eurjchem-11 40 58 usa usa PROPN eurjchem-11 40 59 ) ) PUNCT eurjchem-11 40 60     SPACE eurjchem-11 40 61 was be AUX eurjchem-11 40 62     SPACE eurjchem-11 40 63 equipped equip VERB eurjchem-11 40 64     SPACE eurjchem-11 40 65 with with ADP eurjchem-11 40 66     SPACE eurjchem-11 40 67 quaternary quaternary ADJ eurjchem-11 40 68     SPACE eurjchem-11 40 69 gradient gradient NOUN eurjchem-11 40 70     SPACE eurjchem-11 40 71 pumps pump NOUN eurjchem-11 40 72 , , PUNCT eurjchem-11 40 73     SPACE eurjchem-11 40 74 auto‐sampler auto‐sampler NOUN eurjchem-11 40 75     SPACE eurjchem-11 40 76 and and CCONJ eurjchem-11 40 77     SPACE eurjchem-11 40 78 a a DET eurjchem-11 40 79     SPACE eurjchem-11 40 80 photo photo NOUN eurjchem-11 40 81     SPACE eurjchem-11 40 82 diode diode NOUN eurjchem-11 40 83     SPACE eurjchem-11 40 84 array array NOUN eurjchem-11 40 85     SPACE eurjchem-11 40 86 detector detector NOUN eurjchem-11 40 87     SPACE eurjchem-11 40 88 ( ( PUNCT eurjchem-11 40 89 pda pda NOUN eurjchem-11 40 90     SPACE eurjchem-11 40 91 2996 2996 NUM eurjchem-11 40 92 ) ) PUNCT eurjchem-11 40 93 . . PUNCT eurjchem-11 40 94     SPACE eurjchem-11 41 1 this this DET eurjchem-11 41 2     SPACE eurjchem-11 41 3 hplc hplc NOUN eurjchem-11 41 4     SPACE eurjchem-11 41 5 system system NOUN eurjchem-11 41 6     SPACE eurjchem-11 41 7 was be AUX eurjchem-11 41 8     SPACE eurjchem-11 41 9 connected connect VERB eurjchem-11 41 10     SPACE eurjchem-11 41 11 to to PART eurjchem-11 41 12     SPACE eurjchem-11 41 13 waters water NOUN eurjchem-11 41 14     SPACE eurjchem-11 41 15 qtof qtof PROPN eurjchem-11 41 16     SPACE eurjchem-11 41 17 micro micro ADJ eurjchem-11 41 18     SPACE eurjchem-11 41 19 mass mass ADJ eurjchem-11 41 20     SPACE eurjchem-11 41 21 spectrometer spectrometer NOUN eurjchem-11 41 22     SPACE eurjchem-11 41 23 ( ( PUNCT eurjchem-11 41 24 milford milford NOUN eurjchem-11 41 25 , , PUNCT eurjchem-11 41 26     SPACE eurjchem-11 41 27 ma ma PROPN eurjchem-11 41 28 , , PUNCT eurjchem-11 41 29     SPACE eurjchem-11 41 30 usa usa PROPN eurjchem-11 41 31 ) ) PUNCT eurjchem-11 41 32     SPACE eurjchem-11 41 33 and and CCONJ eurjchem-11 41 34     SPACE eurjchem-11 41 35 operated operate VERB eurjchem-11 41 36     SPACE eurjchem-11 41 37 with with ADP eurjchem-11 41 38     SPACE eurjchem-11 41 39 masslynx masslynx NOUN eurjchem-11 41 40     SPACE eurjchem-11 41 41 software software NOUN eurjchem-11 41 42 . . PUNCT eurjchem-11 41 43             SPACE eurjchem-11 42 1 2.3 2.3 NUM eurjchem-11 42 2 . . PUNCT eurjchem-11 42 3     SPACE eurjchem-11 42 4 diluent diluent PROPN eurjchem-11 42 5           SPACE eurjchem-11 42 6 diluent diluent NOUN eurjchem-11 42 7     SPACE eurjchem-11 42 8 was be AUX eurjchem-11 42 9     SPACE eurjchem-11 42 10 prepared prepare VERB eurjchem-11 42 11     SPACE eurjchem-11 42 12 by by ADP eurjchem-11 42 13     SPACE eurjchem-11 42 14 dissolving dissolve VERB eurjchem-11 42 15     SPACE eurjchem-11 42 16 4 4 NUM eurjchem-11 42 17     SPACE eurjchem-11 42 18 g g NOUN eurjchem-11 42 19     SPACE eurjchem-11 42 20 of of ADP eurjchem-11 42 21     SPACE eurjchem-11 42 22 sodium sodium NOUN eurjchem-11 42 23     SPACE eurjchem-11 42 24 hydroxide hydroxide NOUN eurjchem-11 42 25     SPACE eurjchem-11 42 26 in in ADP eurjchem-11 42 27     SPACE eurjchem-11 42 28 100 100 NUM eurjchem-11 42 29     SPACE eurjchem-11 42 30 ml ml NOUN eurjchem-11 42 31     SPACE eurjchem-11 42 32 water water NOUN eurjchem-11 42 33     SPACE eurjchem-11 42 34 and and CCONJ eurjchem-11 42 35     SPACE eurjchem-11 42 36 then then ADV eurjchem-11 42 37     SPACE eurjchem-11 42 38 diluted dilute VERB eurjchem-11 42 39     SPACE eurjchem-11 42 40 to to ADP eurjchem-11 42 41     SPACE eurjchem-11 42 42 1000 1000 NUM eurjchem-11 42 43     SPACE eurjchem-11 42 44 ml ml NOUN eurjchem-11 42 45     SPACE eurjchem-11 42 46 with with ADP eurjchem-11 42 47     SPACE eurjchem-11 42 48 meoh meoh PROPN eurjchem-11 42 49 . . PUNCT eurjchem-11 42 50         SPACE eurjchem-11 43 1 2.4 2.4 NUM eurjchem-11 43 2 . . PUNCT eurjchem-11 43 3     SPACE eurjchem-11 43 4 controlled control VERB eurjchem-11 43 5     SPACE eurjchem-11 43 6 sample sample NOUN eurjchem-11 43 7     SPACE eurjchem-11 43 8 preparation preparation NOUN eurjchem-11 43 9             SPACE eurjchem-11 43 10 20 20 NUM eurjchem-11 43 11     SPACE eurjchem-11 43 12 tablets tablet NOUN eurjchem-11 43 13     SPACE eurjchem-11 43 14 of of ADP eurjchem-11 43 15     SPACE eurjchem-11 43 16 aripiprazole aripiprazole NOUN eurjchem-11 43 17     SPACE eurjchem-11 43 18 were be AUX eurjchem-11 43 19     SPACE eurjchem-11 43 20 crushed crush VERB eurjchem-11 43 21     SPACE eurjchem-11 43 22 to to ADP eurjchem-11 43 23     SPACE eurjchem-11 43 24 a a DET eurjchem-11 43 25     SPACE eurjchem-11 43 26 fine fine ADJ eurjchem-11 43 27     SPACE eurjchem-11 43 28 powder powder NOUN eurjchem-11 43 29     SPACE eurjchem-11 43 30 and and CCONJ eurjchem-11 43 31     SPACE eurjchem-11 43 32 an an DET eurjchem-11 43 33     SPACE eurjchem-11 43 34 amount amount NOUN eurjchem-11 43 35     SPACE eurjchem-11 43 36 equivalent equivalent NOUN eurjchem-11 43 37     SPACE eurjchem-11 43 38 to to ADP eurjchem-11 43 39     SPACE eurjchem-11 43 40 20 20 NUM eurjchem-11 43 41     SPACE eurjchem-11 43 42 mg mg NOUN eurjchem-11 43 43     SPACE eurjchem-11 43 44 of of ADP eurjchem-11 43 45     SPACE eurjchem-11 43 46 aripiprazole aripiprazole NOUN eurjchem-11 43 47     SPACE eurjchem-11 43 48 was be AUX eurjchem-11 43 49     SPACE eurjchem-11 43 50 transferred transfer VERB eurjchem-11 43 51     SPACE eurjchem-11 43 52 into into ADP eurjchem-11 43 53     SPACE eurjchem-11 43 54 a a DET eurjchem-11 43 55     SPACE eurjchem-11 43 56 100 100 NUM eurjchem-11 43 57     SPACE eurjchem-11 43 58 ml ml NOUN eurjchem-11 43 59     SPACE eurjchem-11 43 60 volumetric volumetric NOUN eurjchem-11 43 61     SPACE eurjchem-11 43 62 flask flask NOUN eurjchem-11 43 63 , , PUNCT eurjchem-11 43 64     SPACE eurjchem-11 43 65 added add VERB eurjchem-11 43 66     SPACE eurjchem-11 43 67 70 70 NUM eurjchem-11 43 68     SPACE eurjchem-11 43 69 ml ml NOUN eurjchem-11 43 70     SPACE eurjchem-11 43 71 of of ADP eurjchem-11 43 72     SPACE eurjchem-11 43 73 diluent diluent NOUN eurjchem-11 43 74     SPACE eurjchem-11 43 75 and and CCONJ eurjchem-11 43 76     SPACE eurjchem-11 43 77 then then ADV eurjchem-11 43 78     SPACE eurjchem-11 43 79 sonicated sonicate VERB eurjchem-11 43 80     SPACE eurjchem-11 43 81 for for ADP eurjchem-11 43 82     SPACE eurjchem-11 43 83 30 30 NUM eurjchem-11 43 84     SPACE eurjchem-11 43 85 min min NOUN eurjchem-11 43 86     SPACE eurjchem-11 43 87 with with ADP eurjchem-11 43 88     SPACE eurjchem-11 43 89 intermittent intermittent VERB eurjchem-11 43 90     SPACE eurjchem-11 43 91 shaking shaking NOUN eurjchem-11 43 92 . . PUNCT eurjchem-11 43 93     SPACE eurjchem-11 43 94 finally finally ADV eurjchem-11 43 95 , , PUNCT eurjchem-11 43 96     SPACE eurjchem-11 43 97 the the DET eurjchem-11 43 98     SPACE eurjchem-11 43 99 volume volume NOUN eurjchem-11 43 100     SPACE eurjchem-11 43 101 of of ADP eurjchem-11 43 102     SPACE eurjchem-11 43 103 the the DET eurjchem-11 43 104     SPACE eurjchem-11 43 105 sample sample NOUN eurjchem-11 43 106     SPACE eurjchem-11 43 107 was be AUX eurjchem-11 43 108     SPACE eurjchem-11 43 109 made make VERB eurjchem-11 43 110     SPACE eurjchem-11 43 111 up up ADP eurjchem-11 43 112     SPACE eurjchem-11 43 113 to to PART eurjchem-11 43 114     SPACE eurjchem-11 43 115 100 100 NUM eurjchem-11 43 116     SPACE eurjchem-11 43 117 ml ml NOUN eurjchem-11 43 118     SPACE eurjchem-11 43 119 with with ADP eurjchem-11 43 120     SPACE eurjchem-11 43 121 diluent diluent NOUN eurjchem-11 43 122 . . PUNCT eurjchem-11 43 123     SPACE eurjchem-11 43 124 subsequently subsequently ADV eurjchem-11 43 125 , , PUNCT eurjchem-11 43 126     SPACE eurjchem-11 43 127 the the DET eurjchem-11 43 128     SPACE eurjchem-11 43 129 solution solution NOUN eurjchem-11 43 130     SPACE eurjchem-11 43 131 was be AUX eurjchem-11 43 132     SPACE eurjchem-11 43 133 filtered filter VERB eurjchem-11 43 134     SPACE eurjchem-11 43 135 through through ADP eurjchem-11 43 136     SPACE eurjchem-11 43 137 a a DET eurjchem-11 43 138     SPACE eurjchem-11 43 139 0.45 0.45 NUM eurjchem-11 43 140     SPACE eurjchem-11 43 141 µm µm NOUN eurjchem-11 43 142     SPACE eurjchem-11 43 143 nylon nylon NOUN eurjchem-11 43 144     SPACE eurjchem-11 43 145 membrane membrane NOUN eurjchem-11 43 146     SPACE eurjchem-11 43 147 filter filter NOUN eurjchem-11 43 148 . . PUNCT eurjchem-11 43 149     SPACE eurjchem-11 43 150 controlled control VERB eurjchem-11 43 151     SPACE eurjchem-11 43 152 sample sample NOUN eurjchem-11 43 153     SPACE eurjchem-11 43 154 was be AUX eurjchem-11 43 155     SPACE eurjchem-11 43 156 prepared prepare VERB eurjchem-11 43 157     SPACE eurjchem-11 43 158 to to PART eurjchem-11 43 159     SPACE eurjchem-11 43 160 confirm confirm VERB eurjchem-11 43 161     SPACE eurjchem-11 43 162 the the DET eurjchem-11 43 163     SPACE eurjchem-11 43 164 drug drug NOUN eurjchem-11 43 165     SPACE eurjchem-11 43 166 product product NOUN eurjchem-11 43 167     SPACE eurjchem-11 43 168 does do AUX eurjchem-11 43 169     SPACE eurjchem-11 43 170 not not PART eurjchem-11 43 171     SPACE eurjchem-11 43 172 have have VERB eurjchem-11 43 173     SPACE eurjchem-11 43 174 any any DET eurjchem-11 43 175     SPACE eurjchem-11 43 176 degradation degradation NOUN eurjchem-11 43 177     SPACE eurjchem-11 43 178 product product NOUN eurjchem-11 43 179 . . PUNCT eurjchem-11 43 180         SPACE eurjchem-11 44 1 2.5 2.5 NUM eurjchem-11 44 2 . . PUNCT eurjchem-11 44 3     SPACE eurjchem-11 45 1 preparation preparation NOUN eurjchem-11 45 2     SPACE eurjchem-11 45 3 of of ADP eurjchem-11 45 4     SPACE eurjchem-11 45 5 spiked spiked ADJ eurjchem-11 45 6     SPACE eurjchem-11 45 7 solution solution NOUN eurjchem-11 45 8     SPACE eurjchem-11 45 9 of of ADP eurjchem-11 45 10     SPACE eurjchem-11 45 11 impurities impurity NOUN eurjchem-11 45 12     SPACE eurjchem-11 45 13 for for ADP eurjchem-11 45 14     SPACE eurjchem-11 45 15 mass mass PROPN eurjchem-11 45 16     SPACE eurjchem-11 45 17 confirmation confirmation NOUN eurjchem-11 45 18           SPACE eurjchem-11 45 19 sample sample NOUN eurjchem-11 45 20     SPACE eurjchem-11 45 21 powder powder NOUN eurjchem-11 45 22     SPACE eurjchem-11 45 23 equivalent equivalent NOUN eurjchem-11 45 24     SPACE eurjchem-11 45 25 to to ADP eurjchem-11 45 26     SPACE eurjchem-11 45 27 20 20 NUM eurjchem-11 45 28     SPACE eurjchem-11 45 29 mg mg NOUN eurjchem-11 45 30     SPACE eurjchem-11 45 31 of of ADP eurjchem-11 45 32     SPACE eurjchem-11 45 33 aripiprazole aripiprazole NOUN eurjchem-11 45 34     SPACE eurjchem-11 45 35 was be AUX eurjchem-11 45 36     SPACE eurjchem-11 45 37 transferred transfer VERB eurjchem-11 45 38     SPACE eurjchem-11 45 39 into into ADP eurjchem-11 45 40     SPACE eurjchem-11 45 41 a a DET eurjchem-11 45 42     SPACE eurjchem-11 45 43 100 100 NUM eurjchem-11 45 44     SPACE eurjchem-11 45 45 ml ml NOUN eurjchem-11 45 46     SPACE eurjchem-11 45 47 volumetric volumetric NOUN eurjchem-11 45 48     SPACE eurjchem-11 45 49 flask flask NOUN eurjchem-11 45 50     SPACE eurjchem-11 45 51 and and CCONJ eurjchem-11 45 52     SPACE eurjchem-11 45 53 2 2 NUM eurjchem-11 45 54     SPACE eurjchem-11 45 55 µg µg NOUN eurjchem-11 45 56     SPACE eurjchem-11 45 57 of of ADP eurjchem-11 45 58     SPACE eurjchem-11 45 59 each each DET eurjchem-11 45 60     SPACE eurjchem-11 45 61 individual individual NOUN eurjchem-11 45 62     SPACE eurjchem-11 45 63 known know VERB eurjchem-11 45 64     SPACE eurjchem-11 45 65 impurity impurity NOUN eurjchem-11 45 66     SPACE eurjchem-11 45 67 were be AUX eurjchem-11 45 68     SPACE eurjchem-11 45 69 added add VERB eurjchem-11 45 70 . . PUNCT eurjchem-11 45 71     SPACE eurjchem-11 46 1 also also ADV eurjchem-11 46 2 , , PUNCT eurjchem-11 46 3     SPACE eurjchem-11 46 4 70 70 NUM eurjchem-11 46 5     SPACE eurjchem-11 46 6 ml ml NOUN eurjchem-11 46 7     SPACE eurjchem-11 46 8 of of ADP eurjchem-11 46 9     SPACE eurjchem-11 46 10 diluent diluent NOUN eurjchem-11 46 11     SPACE eurjchem-11 46 12 was be AUX eurjchem-11 46 13     SPACE eurjchem-11 46 14 added add VERB eurjchem-11 46 15 , , PUNCT eurjchem-11 46 16     SPACE eurjchem-11 46 17 sonicated sonicate VERB eurjchem-11 46 18     SPACE eurjchem-11 46 19 for for ADP eurjchem-11 46 20     SPACE eurjchem-11 46 21 30 30 NUM eurjchem-11 46 22     SPACE eurjchem-11 46 23 min min NOUN eurjchem-11 46 24     SPACE eurjchem-11 46 25 with with ADP eurjchem-11 46 26     SPACE eurjchem-11 46 27 intermittent intermittent VERB eurjchem-11 46 28     SPACE eurjchem-11 46 29 shaking shaking NOUN eurjchem-11 46 30     SPACE eurjchem-11 46 31 and and CCONJ eurjchem-11 46 32     SPACE eurjchem-11 46 33 finally finally ADV eurjchem-11 46 34     SPACE eurjchem-11 46 35 the the DET eurjchem-11 46 36     SPACE eurjchem-11 46 37 volume volume NOUN eurjchem-11 46 38     SPACE eurjchem-11 46 39 was be AUX eurjchem-11 46 40     SPACE eurjchem-11 46 41 completed complete VERB eurjchem-11 46 42     SPACE eurjchem-11 46 43 with with ADP eurjchem-11 46 44     SPACE eurjchem-11 46 45 diluent diluent NOUN eurjchem-11 46 46 . . PUNCT eurjchem-11 46 47     SPACE eurjchem-11 47 1 afterwards afterwards ADV eurjchem-11 47 2 , , PUNCT eurjchem-11 47 3     SPACE eurjchem-11 47 4 the the DET eurjchem-11 47 5     SPACE eurjchem-11 47 6 solution solution NOUN eurjchem-11 47 7     SPACE eurjchem-11 47 8 was be AUX eurjchem-11 47 9     SPACE eurjchem-11 47 10 filtered filter VERB eurjchem-11 47 11     SPACE eurjchem-11 47 12 through through ADP eurjchem-11 47 13     SPACE eurjchem-11 47 14 a a DET eurjchem-11 47 15     SPACE eurjchem-11 47 16 0.45 0.45 NUM eurjchem-11 47 17     SPACE eurjchem-11 47 18 µm µm NOUN eurjchem-11 47 19     SPACE eurjchem-11 47 20 nylon nylon NOUN eurjchem-11 47 21     SPACE eurjchem-11 47 22 membrane membrane NOUN eurjchem-11 47 23     SPACE eurjchem-11 47 24 filter filter NOUN eurjchem-11 47 25 . . PUNCT eurjchem-11 47 26     SPACE eurjchem-11 48 1 the the DET eurjchem-11 48 2     SPACE eurjchem-11 48 3 filtered filter VERB eurjchem-11 48 4     SPACE eurjchem-11 48 5 solution solution NOUN eurjchem-11 48 6     SPACE eurjchem-11 48 7 was be AUX eurjchem-11 48 8     SPACE eurjchem-11 48 9 taken take VERB eurjchem-11 48 10     SPACE eurjchem-11 48 11 as as ADP eurjchem-11 48 12     SPACE eurjchem-11 48 13 impurities impurity NOUN eurjchem-11 48 14 ’ ' PUNCT eurjchem-11 48 15     SPACE eurjchem-11 48 16 spiked spike VERB eurjchem-11 48 17     SPACE eurjchem-11 48 18 solution solution NOUN eurjchem-11 48 19 . . PUNCT eurjchem-11 48 20         SPACE eurjchem-11 49 1 2.6 2.6 NUM eurjchem-11 49 2 . . PUNCT eurjchem-11 49 3     SPACE eurjchem-11 49 4 stress stress NOUN eurjchem-11 49 5     SPACE eurjchem-11 49 6 decomposition decomposition NOUN eurjchem-11 49 7     SPACE eurjchem-11 49 8 studies study NOUN eurjchem-11 49 9           SPACE eurjchem-11 49 10 acidic acidic ADJ eurjchem-11 49 11 , , PUNCT eurjchem-11 49 12     SPACE eurjchem-11 49 13 alkaline alkaline NOUN eurjchem-11 49 14     SPACE eurjchem-11 49 15 and and CCONJ eurjchem-11 49 16     SPACE eurjchem-11 49 17 peroxide peroxide NOUN eurjchem-11 49 18     SPACE eurjchem-11 49 19 degradation degradation NOUN eurjchem-11 49 20     SPACE eurjchem-11 49 21 studies study NOUN eurjchem-11 49 22     SPACE eurjchem-11 49 23 were be AUX eurjchem-11 49 24     SPACE eurjchem-11 49 25 conducted conduct VERB eurjchem-11 49 26     SPACE eurjchem-11 49 27 by by ADP eurjchem-11 49 28     SPACE eurjchem-11 49 29 using use VERB eurjchem-11 49 30     SPACE eurjchem-11 49 31 5 5 NUM eurjchem-11 49 32     SPACE eurjchem-11 49 33 m m VERB eurjchem-11 49 34     SPACE eurjchem-11 49 35 hcl hcl PROPN eurjchem-11 49 36 , , PUNCT eurjchem-11 49 37     SPACE eurjchem-11 49 38 5 5 NUM eurjchem-11 49 39     SPACE eurjchem-11 49 40 m m VERB eurjchem-11 49 41     SPACE eurjchem-11 49 42 naoh naoh NOUN eurjchem-11 49 43     SPACE eurjchem-11 49 44 and and CCONJ eurjchem-11 49 45     SPACE eurjchem-11 49 46 5 5 NUM eurjchem-11 49 47     SPACE eurjchem-11 49 48 ml ml NOUN eurjchem-11 49 49     SPACE eurjchem-11 49 50 of of ADP eurjchem-11 49 51     SPACE eurjchem-11 49 52 30 30 NUM eurjchem-11 49 53 % % NOUN eurjchem-11 49 54     SPACE eurjchem-11 49 55 h2o2 h2o2 NOUN eurjchem-11 49 56 , , PUNCT eurjchem-11 49 57     SPACE eurjchem-11 49 58 respectively respectively ADV eurjchem-11 49 59 . . PUNCT eurjchem-11 49 60     SPACE eurjchem-11 50 1 all all DET eurjchem-11 50 2     SPACE eurjchem-11 50 3 these these DET eurjchem-11 50 4     SPACE eurjchem-11 50 5 studies study NOUN eurjchem-11 50 6     SPACE eurjchem-11 50 7 were be AUX eurjchem-11 50 8     SPACE eurjchem-11 50 9 carried carry VERB eurjchem-11 50 10     SPACE eurjchem-11 50 11 out out ADP eurjchem-11 50 12     SPACE eurjchem-11 50 13 at at ADP eurjchem-11 50 14     SPACE eurjchem-11 50 15 70 70 NUM eurjchem-11 50 16     SPACE eurjchem-11 50 17 ° ° PROPN eurjchem-11 50 18 c c PROPN eurjchem-11 50 19 . . PUNCT eurjchem-11 50 20     SPACE eurjchem-11 50 21 thermal thermal ADJ eurjchem-11 50 22 , , PUNCT eurjchem-11 50 23     SPACE eurjchem-11 50 24 humidity humidity NOUN eurjchem-11 50 25     SPACE eurjchem-11 50 26 and and CCONJ eurjchem-11 50 27     SPACE eurjchem-11 50 28 photolytic photolytic ADJ eurjchem-11 50 29     SPACE eurjchem-11 50 30 conditions condition NOUN eurjchem-11 50 31     SPACE eurjchem-11 50 32 were be AUX eurjchem-11 50 33     SPACE eurjchem-11 50 34 applied apply VERB eurjchem-11 50 35     SPACE eurjchem-11 50 36 as as ADP eurjchem-11 50 37     SPACE eurjchem-11 50 38 per per ADP eurjchem-11 50 39     SPACE eurjchem-11 50 40 the the DET eurjchem-11 50 41     SPACE eurjchem-11 50 42 q1a q1a NOUN eurjchem-11 50 43     SPACE eurjchem-11 50 44 ( ( PUNCT eurjchem-11 50 45 r2 r2 PROPN eurjchem-11 50 46 ) ) PUNCT eurjchem-11 50 47     SPACE eurjchem-11 50 48 ich ich NOUN eurjchem-11 50 49     SPACE eurjchem-11 50 50 guidelines guideline VERB eurjchem-11 50 51     SPACE eurjchem-11 51 1 [ [ X eurjchem-11 51 2 19 19 NUM eurjchem-11 51 3 ] ] PUNCT eurjchem-11 51 4 . . PUNCT eurjchem-11 51 5         SPACE eurjchem-11 51 6 2.7 2.7 NUM eurjchem-11 51 7 . . PUNCT eurjchem-11 51 8     SPACE eurjchem-11 51 9 chromatographic chromatographic ADJ eurjchem-11 51 10     SPACE eurjchem-11 51 11 conditions condition NOUN eurjchem-11 51 12           SPACE eurjchem-11 51 13 the the DET eurjchem-11 51 14     SPACE eurjchem-11 51 15 mobile mobile ADJ eurjchem-11 51 16     SPACE eurjchem-11 51 17 phase phase NOUN eurjchem-11 51 18     SPACE eurjchem-11 51 19 consists consist VERB eurjchem-11 51 20     SPACE eurjchem-11 51 21 of of ADP eurjchem-11 51 22     SPACE eurjchem-11 51 23 a a DET eurjchem-11 51 24     SPACE eurjchem-11 51 25 mixture mixture NOUN eurjchem-11 51 26     SPACE eurjchem-11 51 27 of of ADP eurjchem-11 51 28     SPACE eurjchem-11 51 29 a a PRON eurjchem-11 51 30     SPACE eurjchem-11 51 31 and and CCONJ eurjchem-11 51 32     SPACE eurjchem-11 51 33 b b NOUN eurjchem-11 51 34 ; ; PUNCT eurjchem-11 51 35     SPACE eurjchem-11 51 36 a a PRON eurjchem-11 51 37     SPACE eurjchem-11 51 38 was be AUX eurjchem-11 51 39     SPACE eurjchem-11 51 40 a a DET eurjchem-11 51 41     SPACE eurjchem-11 51 42 buffer buffer NOUN eurjchem-11 51 43     SPACE eurjchem-11 51 44 containing contain VERB eurjchem-11 51 45     SPACE eurjchem-11 51 46 2.54 2.54 NUM eurjchem-11 51 47     SPACE eurjchem-11 51 48 g g NOUN eurjchem-11 51 49     SPACE eurjchem-11 51 50 of of ADP eurjchem-11 51 51     SPACE eurjchem-11 51 52 ammonium ammonium NOUN eurjchem-11 51 53     SPACE eurjchem-11 51 54 acetate acetate NOUN eurjchem-11 51 55     SPACE eurjchem-11 51 56 dissolved dissolve VERB eurjchem-11 51 57     SPACE eurjchem-11 51 58 in in ADP eurjchem-11 51 59     SPACE eurjchem-11 51 60 1000 1000 NUM eurjchem-11 51 61     SPACE eurjchem-11 51 62 ml ml NOUN eurjchem-11 51 63     SPACE eurjchem-11 51 64 water water NOUN eurjchem-11 51 65     SPACE eurjchem-11 51 66 and and CCONJ eurjchem-11 51 67     SPACE eurjchem-11 51 68 its its PRON eurjchem-11 51 69     SPACE eurjchem-11 51 70 ph ph NOUN eurjchem-11 51 71     SPACE eurjchem-11 51 72 was be AUX eurjchem-11 51 73     SPACE eurjchem-11 51 74 adjusted adjust VERB eurjchem-11 51 75     SPACE eurjchem-11 51 76 to to ADP eurjchem-11 51 77     SPACE eurjchem-11 51 78 2.5 2.5 NUM eurjchem-11 51 79     SPACE eurjchem-11 51 80 with with ADP eurjchem-11 51 81     SPACE eurjchem-11 51 82 formic formic ADJ eurjchem-11 51 83     SPACE eurjchem-11 51 84 acid acid NOUN eurjchem-11 51 85 . . PUNCT eurjchem-11 51 86     SPACE eurjchem-11 52 1 b b X eurjchem-11 52 2     SPACE eurjchem-11 52 3 was be AUX eurjchem-11 52 4     SPACE eurjchem-11 52 5 meoh meoh NOUN eurjchem-11 52 6 : : PUNCT eurjchem-11 52 7 acn acn PROPN eurjchem-11 52 8     SPACE eurjchem-11 52 9 in in ADP eurjchem-11 52 10     SPACE eurjchem-11 52 11 the the DET eurjchem-11 52 12     SPACE eurjchem-11 52 13 ratio ratio NOUN eurjchem-11 52 14     SPACE eurjchem-11 52 15 of of ADP eurjchem-11 52 16     SPACE eurjchem-11 52 17 50:50 50:50 NUM eurjchem-11 52 18 . . PUNCT eurjchem-11 52 19     SPACE eurjchem-11 53 1 the the DET eurjchem-11 53 2     SPACE eurjchem-11 53 3 chromatographic chromatographic ADJ eurjchem-11 53 4     SPACE eurjchem-11 53 5 separation separation NOUN eurjchem-11 53 6     SPACE eurjchem-11 53 7 was be AUX eurjchem-11 53 8     SPACE eurjchem-11 53 9 achieved achieve VERB eurjchem-11 53 10     SPACE eurjchem-11 53 11 on on ADP eurjchem-11 53 12     SPACE eurjchem-11 53 13 symmetry symmetry NOUN eurjchem-11 53 14     SPACE eurjchem-11 53 15 c‐18 c‐18 PROPN eurjchem-11 53 16 , , PUNCT eurjchem-11 53 17     SPACE eurjchem-11 53 18 250 250 NUM eurjchem-11 53 19     SPACE eurjchem-11 53 20 x x NOUN eurjchem-11 53 21     SPACE eurjchem-11 53 22 4.6 4.6 NUM eurjchem-11 53 23     SPACE eurjchem-11 53 24 mm mm PROPN eurjchem-11 53 25 , , PUNCT eurjchem-11 53 26     SPACE eurjchem-11 53 27 5 5 NUM eurjchem-11 53 28     SPACE eurjchem-11 53 29 µm µm NOUN eurjchem-11 53 30     SPACE eurjchem-11 53 31 column column NOUN eurjchem-11 53 32     SPACE eurjchem-11 53 33 by by ADP eurjchem-11 53 34     SPACE eurjchem-11 53 35 performing perform VERB eurjchem-11 53 36     SPACE eurjchem-11 53 37 gradient gradient NOUN eurjchem-11 53 38     SPACE eurjchem-11 53 39 programme programme NOUN eurjchem-11 53 40     SPACE eurjchem-11 53 41 with with ADP eurjchem-11 53 42     SPACE eurjchem-11 53 43 a a DET eurjchem-11 53 44     SPACE eurjchem-11 53 45 flow flow NOUN eurjchem-11 53 46     SPACE eurjchem-11 53 47 rate rate NOUN eurjchem-11 53 48     SPACE eurjchem-11 53 49 of of ADP eurjchem-11 53 50     SPACE eurjchem-11 53 51 1.0 1.0 NUM eurjchem-11 53 52     SPACE eurjchem-11 53 53 ml ml NOUN eurjchem-11 53 54 / / SYM eurjchem-11 53 55 min min NOUN eurjchem-11 53 56 . . PROPN eurjchem-11 53 57     SPACE eurjchem-11 53 58 the the DET eurjchem-11 53 59     SPACE eurjchem-11 53 60 gradient gradient NOUN eurjchem-11 53 61     SPACE eurjchem-11 53 62 programme programme NOUN eurjchem-11 53 63     SPACE eurjchem-11 53 64 performed perform VERB eurjchem-11 53 65     SPACE eurjchem-11 53 66 for for ADP eurjchem-11 53 67     SPACE eurjchem-11 53 68 separation separation NOUN eurjchem-11 53 69     SPACE eurjchem-11 53 70 was be AUX eurjchem-11 53 71     SPACE eurjchem-11 53 72 shown show VERB eurjchem-11 53 73     SPACE eurjchem-11 53 74 in in ADP eurjchem-11 53 75     SPACE eurjchem-11 53 76 table table NOUN eurjchem-11 53 77     SPACE eurjchem-11 53 78 1 1 NUM eurjchem-11 53 79 . . PUNCT eurjchem-11 53 80     SPACE eurjchem-11 53 81 the the DET eurjchem-11 53 82     SPACE eurjchem-11 53 83 detection detection NOUN eurjchem-11 53 84     SPACE eurjchem-11 53 85 wavelength wavelength NOUN eurjchem-11 53 86     SPACE eurjchem-11 53 87 was be AUX eurjchem-11 53 88     SPACE eurjchem-11 53 89 set set VERB eurjchem-11 53 90     SPACE eurjchem-11 53 91 at at ADP eurjchem-11 53 92     SPACE eurjchem-11 53 93 248 248 NUM eurjchem-11 53 94     SPACE eurjchem-11 53 95 nm nm NOUN eurjchem-11 53 96     SPACE eurjchem-11 53 97 and and CCONJ eurjchem-11 53 98     SPACE eurjchem-11 53 99 the the DET eurjchem-11 53 100     SPACE eurjchem-11 53 101 injection injection NOUN eurjchem-11 53 102     SPACE eurjchem-11 53 103 volume volume NOUN eurjchem-11 53 104     SPACE eurjchem-11 53 105 was be AUX eurjchem-11 53 106     SPACE eurjchem-11 53 107 10 10 NUM eurjchem-11 53 108     SPACE eurjchem-11 53 109 µl µl NOUN eurjchem-11 53 110 . . PUNCT eurjchem-11 53 111           SPACE eurjchem-11 53 112 table table NOUN eurjchem-11 53 113     SPACE eurjchem-11 53 114 1 1 NUM eurjchem-11 53 115 . . PUNCT eurjchem-11 53 116     SPACE eurjchem-11 53 117 gradient gradient NOUN eurjchem-11 53 118     SPACE eurjchem-11 53 119 program program NOUN eurjchem-11 53 120 . . PUNCT eurjchem-11 53 121     SPACE eurjchem-11 53 122 time time NOUN eurjchem-11 53 123     SPACE eurjchem-11 53 124 flow flow NOUN eurjchem-11 53 125     SPACE eurjchem-11 53 126 % % NOUN eurjchem-11 53 127 , , PUNCT eurjchem-11 53 128     SPACE eurjchem-11 53 129 a a DET eurjchem-11 53 130     SPACE eurjchem-11 53 131 % % NOUN eurjchem-11 53 132 , , PUNCT eurjchem-11 53 133     SPACE eurjchem-11 53 134 b b NOUN eurjchem-11 53 135     SPACE eurjchem-11 53 136 0.00 0.00 NUM eurjchem-11 53 137 1.0 1.0 NUM eurjchem-11 53 138 75 75 NUM eurjchem-11 53 139     SPACE eurjchem-11 53 140 25 25 NUM eurjchem-11 53 141 40.0 40.0 NUM eurjchem-11 53 142 1.0 1.0 NUM eurjchem-11 53 143 40 40 NUM eurjchem-11 53 144     SPACE eurjchem-11 53 145 60 60 NUM eurjchem-11 53 146 50.0 50.0 NUM eurjchem-11 53 147 1.0 1.0 NUM eurjchem-11 53 148 40 40 NUM eurjchem-11 53 149     SPACE eurjchem-11 53 150 60 60 NUM eurjchem-11 53 151 55.0 55.0 NUM eurjchem-11 53 152 1.0 1.0 NUM eurjchem-11 53 153 75 75 NUM eurjchem-11 53 154     SPACE eurjchem-11 53 155 25 25 NUM eurjchem-11 53 156 65.0 65.0 NUM eurjchem-11 53 157 1.0 1.0 NUM eurjchem-11 53 158 75 75 NUM eurjchem-11 53 159     SPACE eurjchem-11 53 160 25 25 NUM eurjchem-11 53 161     SPACE eurjchem-11 53 162 2.8 2.8 NUM eurjchem-11 53 163 . . PUNCT eurjchem-11 53 164     SPACE eurjchem-11 53 165 qtof qtof PROPN eurjchem-11 53 166     SPACE eurjchem-11 53 167 mass mass PROPN eurjchem-11 53 168     SPACE eurjchem-11 53 169 spectrometric spectrometric ADJ eurjchem-11 53 170     SPACE eurjchem-11 53 171 conditions condition NOUN eurjchem-11 53 172         SPACE eurjchem-11 53 173 for for ADP eurjchem-11 53 174     SPACE eurjchem-11 53 175 mass mass ADJ eurjchem-11 53 176     SPACE eurjchem-11 53 177 spectrometry spectrometry NOUN eurjchem-11 53 178     SPACE eurjchem-11 53 179 detection detection NOUN eurjchem-11 53 180 , , PUNCT eurjchem-11 53 181     SPACE eurjchem-11 53 182 the the DET eurjchem-11 53 183     SPACE eurjchem-11 53 184 parameters parameter NOUN eurjchem-11 53 185     SPACE eurjchem-11 53 186 were be AUX eurjchem-11 53 187     SPACE eurjchem-11 53 188 tuned tune VERB eurjchem-11 53 189     SPACE eurjchem-11 53 190 by by ADP eurjchem-11 53 191     SPACE eurjchem-11 53 192 injecting inject VERB eurjchem-11 53 193     SPACE eurjchem-11 53 194 low low ADJ eurjchem-11 53 195     SPACE eurjchem-11 53 196 concentrated concentrate VERB eurjchem-11 53 197     SPACE eurjchem-11 53 198 aripiprazole aripiprazole PROPN eurjchem-11 53 199     SPACE eurjchem-11 53 200 standard standard NOUN eurjchem-11 53 201     SPACE eurjchem-11 53 202 for for ADP eurjchem-11 53 203     SPACE eurjchem-11 53 204 better well ADJ eurjchem-11 53 205     SPACE eurjchem-11 53 206 mass mass ADJ eurjchem-11 53 207     SPACE eurjchem-11 53 208 sensitivity sensitivity NOUN eurjchem-11 53 209 . . PUNCT eurjchem-11 53 210     SPACE eurjchem-11 54 1 qtof qtof PROPN eurjchem-11 54 2     SPACE eurjchem-11 54 3 mass mass PROPN eurjchem-11 54 4     SPACE eurjchem-11 54 5 spectrometer spectrometer NOUN eurjchem-11 54 6     SPACE eurjchem-11 54 7 was be AUX eurjchem-11 54 8     SPACE eurjchem-11 54 9 provided provide VERB eurjchem-11 54 10     SPACE eurjchem-11 54 11 with with ADP eurjchem-11 54 12     SPACE eurjchem-11 54 13 electrospray electrospray VERB eurjchem-11 54 14     SPACE eurjchem-11 54 15 ionization ionization NOUN eurjchem-11 54 16     SPACE eurjchem-11 54 17 source source NOUN eurjchem-11 54 18     SPACE eurjchem-11 54 19 and and CCONJ eurjchem-11 54 20     SPACE eurjchem-11 54 21 operating operate VERB eurjchem-11 54 22     SPACE eurjchem-11 54 23 parameters parameter NOUN eurjchem-11 54 24     SPACE eurjchem-11 54 25 were be AUX eurjchem-11 54 26     SPACE eurjchem-11 54 27 as as SCONJ eurjchem-11 54 28     SPACE eurjchem-11 54 29 follows follow VERB eurjchem-11 54 30 : : PUNCT eurjchem-11 54 31     SPACE eurjchem-11 54 32 capillary capillary ADJ eurjchem-11 54 33     SPACE eurjchem-11 54 34 voltage voltage NOUN eurjchem-11 54 35 , , PUNCT eurjchem-11 54 36     SPACE eurjchem-11 54 37 3500 3500 NUM eurjchem-11 54 38     SPACE eurjchem-11 54 39 v v NOUN eurjchem-11 54 40 ; ; PUNCT eurjchem-11 54 41     SPACE eurjchem-11 54 42 sample sample NOUN eurjchem-11 54 43     SPACE eurjchem-11 54 44 cone cone NOUN eurjchem-11 54 45     SPACE eurjchem-11 54 46 voltage voltage NOUN eurjchem-11 54 47 , , PUNCT eurjchem-11 54 48     SPACE eurjchem-11 54 49 35 35 NUM eurjchem-11 54 50     SPACE eurjchem-11 54 51 v v NOUN eurjchem-11 54 52 ; ; PUNCT eurjchem-11 54 53     SPACE eurjchem-11 54 54 extraction extraction NOUN eurjchem-11 54 55     SPACE eurjchem-11 54 56 cone cone NOUN eurjchem-11 54 57     SPACE eurjchem-11 54 58 voltage voltage NOUN eurjchem-11 54 59 , , PUNCT eurjchem-11 54 60     SPACE eurjchem-11 54 61 2.0 2.0 NUM eurjchem-11 54 62     SPACE eurjchem-11 54 63 v. v. NOUN eurjchem-11 54 64     SPACE eurjchem-11 54 65 collision collision NOUN eurjchem-11 54 66     SPACE eurjchem-11 54 67 energy energy NOUN eurjchem-11 54 68     SPACE eurjchem-11 54 69 was be AUX eurjchem-11 54 70     SPACE eurjchem-11 54 71 initially initially ADV eurjchem-11 54 72     SPACE eurjchem-11 54 73 set set VERB eurjchem-11 54 74     SPACE eurjchem-11 54 75 at at ADP eurjchem-11 54 76     SPACE eurjchem-11 54 77 5.0 5.0 NUM eurjchem-11 54 78     SPACE eurjchem-11 54 79 ev ev NOUN eurjchem-11 54 80     SPACE eurjchem-11 54 81 for for ADP eurjchem-11 54 82     SPACE eurjchem-11 54 83 ms ms NOUN eurjchem-11 54 84     SPACE eurjchem-11 54 85 experiments experiment NOUN eurjchem-11 54 86     SPACE eurjchem-11 54 87 and and CCONJ eurjchem-11 54 88     SPACE eurjchem-11 54 89 varied varied ADJ eurjchem-11 54 90     SPACE eurjchem-11 54 91 from from ADP eurjchem-11 54 92     SPACE eurjchem-11 54 93 5 5 NUM eurjchem-11 54 94     SPACE eurjchem-11 54 95 to to PART eurjchem-11 54 96     SPACE eurjchem-11 54 97 30 30 NUM eurjchem-11 54 98     SPACE eurjchem-11 54 99 ev ev NOUN eurjchem-11 54 100     SPACE eurjchem-11 54 101 for for ADP eurjchem-11 54 102     SPACE eurjchem-11 54 103 ms ms PROPN eurjchem-11 54 104 / / SYM eurjchem-11 54 105 ms ms NOUN eurjchem-11 54 106     SPACE eurjchem-11 54 107 experiments experiment NOUN eurjchem-11 54 108 . . PUNCT eurjchem-11 54 109     SPACE eurjchem-11 54 110 nitrogen nitrogen NOUN eurjchem-11 54 111     SPACE eurjchem-11 54 112 gas gas NOUN eurjchem-11 54 113     SPACE eurjchem-11 54 114 was be AUX eurjchem-11 54 115     SPACE eurjchem-11 54 116 used use VERB eurjchem-11 54 117     SPACE eurjchem-11 54 118 as as ADP eurjchem-11 54 119     SPACE eurjchem-11 54 120 nebulizer nebulizer NOUN eurjchem-11 54 121     SPACE eurjchem-11 54 122 gas gas NOUN eurjchem-11 54 123     SPACE eurjchem-11 54 124 and and CCONJ eurjchem-11 54 125     SPACE eurjchem-11 54 126 helium helium NOUN eurjchem-11 54 127     SPACE eurjchem-11 54 128 gas gas NOUN eurjchem-11 54 129     SPACE eurjchem-11 54 130 as as ADP eurjchem-11 54 131     SPACE eurjchem-11 54 132 collision collision NOUN eurjchem-11 54 133     SPACE eurjchem-11 54 134 gas gas NOUN eurjchem-11 54 135 . . PUNCT eurjchem-11 54 136     SPACE eurjchem-11 54 137 nebulizer nebulizer NOUN eurjchem-11 54 138     SPACE eurjchem-11 54 139 gas gas NOUN eurjchem-11 54 140     SPACE eurjchem-11 54 141 was be AUX eurjchem-11 54 142     SPACE eurjchem-11 54 143 supplied supply VERB eurjchem-11 54 144     SPACE eurjchem-11 54 145 with with ADP eurjchem-11 54 146     SPACE eurjchem-11 54 147 a a DET eurjchem-11 54 148     SPACE eurjchem-11 54 149 flow flow NOUN eurjchem-11 54 150     SPACE eurjchem-11 54 151 rate rate NOUN eurjchem-11 54 152     SPACE eurjchem-11 54 153 of of ADP eurjchem-11 54 154     SPACE eurjchem-11 54 155 50 50 NUM eurjchem-11 54 156     SPACE eurjchem-11 54 157 l l NOUN eurjchem-11 54 158 / / SYM eurjchem-11 54 159 hr hr NOUN eurjchem-11 54 160     SPACE eurjchem-11 54 161 and and CCONJ eurjchem-11 54 162     SPACE eurjchem-11 54 163 dry dry ADJ eurjchem-11 54 164     SPACE eurjchem-11 54 165 gas gas NOUN eurjchem-11 54 166     SPACE eurjchem-11 54 167 of of ADP eurjchem-11 54 168     SPACE eurjchem-11 54 169 500 500 NUM eurjchem-11 54 170     SPACE eurjchem-11 54 171 l l NOUN eurjchem-11 54 172 / / SYM eurjchem-11 54 173 hr hr NOUN eurjchem-11 54 174 . . PUNCT eurjchem-11 54 175     SPACE eurjchem-11 54 176 in in ADP eurjchem-11 54 177     SPACE eurjchem-11 54 178 the the DET eurjchem-11 54 179     SPACE eurjchem-11 54 180 time‐of‐flight time‐of‐flight NOUN eurjchem-11 54 181     SPACE eurjchem-11 54 182 analyzer analyzer NOUN eurjchem-11 54 183 , , PUNCT eurjchem-11 54 184     SPACE eurjchem-11 54 185 the the DET eurjchem-11 54 186     SPACE eurjchem-11 54 187 flight flight NOUN eurjchem-11 54 188     SPACE eurjchem-11 54 189 tube tube NOUN eurjchem-11 54 190     SPACE eurjchem-11 54 191 voltage voltage NOUN eurjchem-11 54 192     SPACE eurjchem-11 54 193 was be AUX eurjchem-11 54 194     SPACE eurjchem-11 54 195 set set VERB eurjchem-11 54 196     SPACE eurjchem-11 54 197 at at ADP eurjchem-11 54 198     SPACE eurjchem-11 54 199 5630 5630 NUM eurjchem-11 54 200     SPACE eurjchem-11 54 201 v v NOUN eurjchem-11 54 202     SPACE eurjchem-11 54 203 and and CCONJ eurjchem-11 54 204     SPACE eurjchem-11 54 205 the the DET eurjchem-11 54 206     SPACE eurjchem-11 54 207 detector detector NOUN eurjchem-11 54 208     SPACE eurjchem-11 54 209 voltage voltage NOUN eurjchem-11 54 210     SPACE eurjchem-11 54 211 was be AUX eurjchem-11 54 212     SPACE eurjchem-11 54 213 2550 2550 NUM eurjchem-11 54 214     SPACE eurjchem-11 54 215 v. v. ADV eurjchem-11 54 216     SPACE eurjchem-11 54 217 all all PRON eurjchem-11 54 218     SPACE eurjchem-11 54 219 the the DET eurjchem-11 54 220     SPACE eurjchem-11 54 221 experiments experiment NOUN eurjchem-11 54 222     SPACE eurjchem-11 54 223 were be AUX eurjchem-11 54 224     SPACE eurjchem-11 54 225 carried carry VERB eurjchem-11 54 226     SPACE eurjchem-11 54 227 out out ADP eurjchem-11 54 228     SPACE eurjchem-11 54 229 in in ADP eurjchem-11 54 230     SPACE eurjchem-11 54 231 the the DET eurjchem-11 54 232     SPACE eurjchem-11 54 233 positive positive ADJ eurjchem-11 54 234     SPACE eurjchem-11 54 235 ionization ionization NOUN eurjchem-11 54 236     SPACE eurjchem-11 54 237 mode mode NOUN eurjchem-11 54 238 . . PUNCT eurjchem-11 54 239           SPACE eurjchem-11 55 1 3 3 NUM eurjchem-11 55 2 . . PUNCT eurjchem-11 55 3     SPACE eurjchem-11 55 4 results result VERB eurjchem-11 55 5     SPACE eurjchem-11 55 6 and and CCONJ eurjchem-11 55 7     SPACE eurjchem-11 55 8 discussion discussion NOUN eurjchem-11 55 9         SPACE eurjchem-11 55 10 3.1 3.1 NUM eurjchem-11 55 11 . . PUNCT eurjchem-11 55 12     SPACE eurjchem-11 55 13 development development NOUN eurjchem-11 55 14     SPACE eurjchem-11 55 15 and and CCONJ eurjchem-11 55 16     SPACE eurjchem-11 55 17 optimization optimization NOUN eurjchem-11 55 18     SPACE eurjchem-11 55 19 of of ADP eurjchem-11 55 20     SPACE eurjchem-11 55 21 lc lc NOUN eurjchem-11 55 22     SPACE eurjchem-11 55 23 method method NOUN eurjchem-11 55 24           SPACE eurjchem-11 55 25 the the DET eurjchem-11 55 26     SPACE eurjchem-11 55 27 optimum optimum ADJ eurjchem-11 55 28     SPACE eurjchem-11 55 29 chromatographic chromatographic ADJ eurjchem-11 55 30     SPACE eurjchem-11 55 31 resolution resolution NOUN eurjchem-11 55 32     SPACE eurjchem-11 55 33 of of ADP eurjchem-11 55 34     SPACE eurjchem-11 55 35 aripiprazole aripiprazole NOUN eurjchem-11 55 36     SPACE eurjchem-11 55 37 and and CCONJ eurjchem-11 55 38     SPACE eurjchem-11 55 39 its its PRON eurjchem-11 55 40     SPACE eurjchem-11 55 41 degradation degradation NOUN eurjchem-11 55 42     SPACE eurjchem-11 55 43 products product NOUN eurjchem-11 55 44     SPACE eurjchem-11 55 45 was be AUX eurjchem-11 55 46     SPACE eurjchem-11 55 47 influenced influence VERB eurjchem-11 55 48     SPACE eurjchem-11 55 49 by by ADP eurjchem-11 55 50     SPACE eurjchem-11 55 51 the the DET eurjchem-11 55 52     SPACE eurjchem-11 55 53 ph ph NOUN eurjchem-11 55 54     SPACE eurjchem-11 55 55 of of ADP eurjchem-11 55 56     SPACE eurjchem-11 55 57 the the DET eurjchem-11 55 58     SPACE eurjchem-11 55 59 aqueous aqueous ADJ eurjchem-11 55 60     SPACE eurjchem-11 55 61 phase phase NOUN eurjchem-11 55 62     SPACE eurjchem-11 55 63 ( ( PUNCT eurjchem-11 55 64 mobile mobile ADJ eurjchem-11 55 65     SPACE eurjchem-11 55 66 phase phase NOUN eurjchem-11 55 67     SPACE eurjchem-11 55 68 a a NOUN eurjchem-11 55 69 ) ) PUNCT eurjchem-11 55 70 , , PUNCT eurjchem-11 55 71     SPACE eurjchem-11 55 72 ratio ratio NOUN eurjchem-11 55 73     SPACE eurjchem-11 55 74 of of ADP eurjchem-11 55 75     SPACE eurjchem-11 55 76 the the DET eurjchem-11 55 77     SPACE eurjchem-11 55 78 organic organic ADJ eurjchem-11 55 79     SPACE eurjchem-11 55 80 modifier modifier NOUN eurjchem-11 55 81     SPACE eurjchem-11 55 82 ( ( PUNCT eurjchem-11 55 83 mobile mobile ADJ eurjchem-11 55 84     SPACE eurjchem-11 55 85 phase phase NOUN eurjchem-11 55 86     SPACE eurjchem-11 55 87 b b NOUN eurjchem-11 55 88 ) ) PUNCT eurjchem-11 55 89     SPACE eurjchem-11 55 90 and and CCONJ eurjchem-11 55 91     SPACE eurjchem-11 55 92 the the DET eurjchem-11 55 93     SPACE eurjchem-11 55 94 flow flow NOUN eurjchem-11 55 95     SPACE eurjchem-11 55 96 rate rate NOUN eurjchem-11 55 97     SPACE eurjchem-11 55 98 of of ADP eurjchem-11 55 99     SPACE eurjchem-11 55 100 the the DET eurjchem-11 55 101     SPACE eurjchem-11 55 102 mobile mobile ADJ eurjchem-11 55 103     SPACE eurjchem-11 55 104 phase phase NOUN eurjchem-11 55 105 . . PUNCT eurjchem-11 55 106     SPACE eurjchem-11 56 1 at at ADP eurjchem-11 56 2     SPACE eurjchem-11 56 3 the the DET eurjchem-11 56 4     SPACE eurjchem-11 56 5 beginning beginning NOUN eurjchem-11 56 6 , , PUNCT eurjchem-11 56 7     SPACE eurjchem-11 56 8 ammonium ammonium NOUN eurjchem-11 56 9     SPACE eurjchem-11 56 10 acetate acetate NOUN eurjchem-11 56 11     SPACE eurjchem-11 56 12 buffer buffer NOUN eurjchem-11 56 13     SPACE eurjchem-11 56 14 at at ADP eurjchem-11 56 15     SPACE eurjchem-11 56 16 ph ph NOUN eurjchem-11 56 17     SPACE eurjchem-11 56 18 5.0 5.0 NUM eurjchem-11 56 19     SPACE eurjchem-11 56 20 was be AUX eurjchem-11 56 21     SPACE eurjchem-11 56 22 tried try VERB eurjchem-11 56 23     SPACE eurjchem-11 56 24 to to PART eurjchem-11 56 25     SPACE eurjchem-11 56 26 separate separate VERB eurjchem-11 56 27     SPACE eurjchem-11 56 28 all all DET eurjchem-11 56 29     SPACE eurjchem-11 56 30 the the DET eurjchem-11 56 31     SPACE eurjchem-11 56 32 known know VERB eurjchem-11 56 33     SPACE eurjchem-11 56 34 impurities impurity NOUN eurjchem-11 56 35     SPACE eurjchem-11 56 36 and and CCONJ eurjchem-11 56 37     SPACE eurjchem-11 56 38 the the DET eurjchem-11 56 39     SPACE eurjchem-11 56 40 degradants degradant NOUN eurjchem-11 56 41 . . PUNCT eurjchem-11 56 42     SPACE eurjchem-11 57 1 it it PRON eurjchem-11 57 2                 SPACE eurjchem-11 57 3 was be AUX eurjchem-11 57 4       SPACE eurjchem-11 57 5 found find VERB eurjchem-11 57 6       SPACE eurjchem-11 57 7 that that SCONJ eurjchem-11 57 8       SPACE eurjchem-11 57 9 the the DET eurjchem-11 57 10     SPACE eurjchem-11 57 11 unknown unknown NOUN eurjchem-11 57 12     SPACE eurjchem-11 57 13 impurity‐1 impurity‐1 PRON eurjchem-11 57 14     SPACE eurjchem-11 57 15 formed form VERB eurjchem-11 57 16     SPACE eurjchem-11 57 17 in in ADP eurjchem-11 57 18       SPACE eurjchem-11 57 19 thermal thermal ADJ eurjchem-11 57 20           SPACE eurjchem-11 57 21 n n ADP eurjchem-11 57 22 h h NOUN eurjchem-11 57 23 o o NOUN eurjchem-11 57 24 n n CCONJ eurjchem-11 57 25 n n CCONJ eurjchem-11 57 26 cl cl NOUN eurjchem-11 57 27 cl cl NOUN eurjchem-11 57 28 o o NOUN eurjchem-11 58 1 n n CCONJ eurjchem-11 58 2 h h NOUN eurjchem-11 58 3 oho oho NOUN eurjchem-11 58 4 nh nh PROPN eurjchem-11 58 5 n n ADV eurjchem-11 58 6 cl cl NOUN eurjchem-11 58 7 cl cl NOUN eurjchem-11 58 8 hcl hcl NOUN eurjchem-11 59 1 o o NOUN eurjchem-11 60 1 o o X eurjchem-11 60 2 o o NOUN eurjchem-11 61 1 n n CCONJ eurjchem-11 61 2 h h NOUN eurjchem-11 62 1 o o NOUN eurjchem-11 62 2 n n CCONJ eurjchem-11 62 3 o o NOUN eurjchem-11 62 4 br br NOUN eurjchem-11 62 5 o o NOUN eurjchem-11 63 1 n n CCONJ eurjchem-11 63 2 o o NOUN eurjchem-11 63 3 n n CCONJ eurjchem-11 63 4 n n CCONJ eurjchem-11 63 5 cl cl NOUN eurjchem-11 63 6 cl cl NOUN eurjchem-11 64 1 o o NOUN eurjchem-11 64 2 o o NOUN eurjchem-11 64 3 n n CCONJ eurjchem-11 64 4 ho ho PROPN eurjchem-11 64 5 22 22 NUM eurjchem-11 64 6     SPACE eurjchem-11 64 7 reddy reddy PROPN eurjchem-11 64 8     SPACE eurjchem-11 64 9 et et PROPN eurjchem-11 64 10     SPACE eurjchem-11 64 11 al al PROPN eurjchem-11 64 12 . . PROPN eurjchem-11 64 13     SPACE eurjchem-11 64 14 / / SYM eurjchem-11 64 15     SPACE eurjchem-11 64 16 european european ADJ eurjchem-11 64 17     SPACE eurjchem-11 64 18 journal journal NOUN eurjchem-11 64 19     SPACE eurjchem-11 64 20 of of ADP eurjchem-11 64 21     SPACE eurjchem-11 64 22 chemistry chemistry NOUN eurjchem-11 64 23     SPACE eurjchem-11 64 24 1 1 NUM eurjchem-11 64 25     SPACE eurjchem-11 64 26 ( ( PUNCT eurjchem-11 64 27 1 1 NUM eurjchem-11 64 28 ) ) PUNCT eurjchem-11 64 29     SPACE eurjchem-11 64 30 ( ( PUNCT eurjchem-11 64 31 2010 2010 NUM eurjchem-11 64 32 ) ) PUNCT eurjchem-11 64 33     SPACE eurjchem-11 65 1 20­27 20­27 NUM eurjchem-11 65 2                     SPACE eurjchem-11 65 3 ( ( PUNCT eurjchem-11 65 4 a a X eurjchem-11 65 5 ) ) PUNCT eurjchem-11 65 6     SPACE eurjchem-11 65 7 ( ( PUNCT eurjchem-11 65 8 b b NOUN eurjchem-11 65 9 ) ) PUNCT eurjchem-11 65 10           SPACE eurjchem-11 65 11 figure figure NOUN eurjchem-11 65 12     SPACE eurjchem-11 65 13 2 2 NUM eurjchem-11 65 14 . . PUNCT eurjchem-11 65 15     SPACE eurjchem-11 65 16 chromatogram chromatogram PROPN eurjchem-11 65 17     SPACE eurjchem-11 65 18 of of ADP eurjchem-11 65 19     SPACE eurjchem-11 65 20 control control NOUN eurjchem-11 65 21     SPACE eurjchem-11 65 22 sample sample NOUN eurjchem-11 65 23     SPACE eurjchem-11 65 24 of of ADP eurjchem-11 65 25     SPACE eurjchem-11 65 26 aripiprazole aripiprazole NOUN eurjchem-11 65 27     SPACE eurjchem-11 65 28 tablet tablet NOUN eurjchem-11 65 29     SPACE eurjchem-11 65 30 sample sample NOUN eurjchem-11 65 31     SPACE eurjchem-11 65 32 ( ( PUNCT eurjchem-11 65 33 a a NOUN eurjchem-11 65 34 ) ) PUNCT eurjchem-11 65 35     SPACE eurjchem-11 65 36 and and CCONJ eurjchem-11 65 37     SPACE eurjchem-11 65 38 its its PRON eurjchem-11 65 39     SPACE eurjchem-11 65 40 impurities impurity NOUN eurjchem-11 65 41     SPACE eurjchem-11 65 42 spiked spike VERB eurjchem-11 65 43     SPACE eurjchem-11 65 44 solution solution NOUN eurjchem-11 65 45     SPACE eurjchem-11 65 46 ( ( PUNCT eurjchem-11 65 47 b b NOUN eurjchem-11 65 48 ) ) PUNCT eurjchem-11 65 49             SPACE eurjchem-11 65 50 degradation degradation NOUN eurjchem-11 65 51     SPACE eurjchem-11 65 52 was be AUX eurjchem-11 65 53     SPACE eurjchem-11 65 54 merged merge VERB eurjchem-11 65 55     SPACE eurjchem-11 65 56 with with ADP eurjchem-11 65 57     SPACE eurjchem-11 65 58 dcpp dcpp NOUN eurjchem-11 65 59     SPACE eurjchem-11 65 60 impurity impurity NOUN eurjchem-11 65 61     SPACE eurjchem-11 65 62 and and CCONJ eurjchem-11 65 63     SPACE eurjchem-11 65 64 apr‐1 apr‐1 NOUN eurjchem-11 65 65     SPACE eurjchem-11 65 66 impurity impurity NOUN eurjchem-11 65 67     SPACE eurjchem-11 65 68 was be AUX eurjchem-11 65 69     SPACE eurjchem-11 65 70 eluted elute VERB eurjchem-11 65 71     SPACE eurjchem-11 65 72 along along ADP eurjchem-11 65 73     SPACE eurjchem-11 65 74 with with ADP eurjchem-11 65 75     SPACE eurjchem-11 65 76 n‐bdq n‐bdq PROPN eurjchem-11 65 77     SPACE eurjchem-11 65 78 impurity impurity NOUN eurjchem-11 65 79 . . PUNCT eurjchem-11 65 80     SPACE eurjchem-11 65 81 after after ADP eurjchem-11 65 82     SPACE eurjchem-11 65 83 changing change VERB eurjchem-11 65 84     SPACE eurjchem-11 65 85 the the DET eurjchem-11 65 86     SPACE eurjchem-11 65 87 ph ph NOUN eurjchem-11 65 88     SPACE eurjchem-11 65 89 of of ADP eurjchem-11 65 90     SPACE eurjchem-11 65 91 the the DET eurjchem-11 65 92     SPACE eurjchem-11 65 93 buffer buffer NOUN eurjchem-11 65 94     SPACE eurjchem-11 65 95 to to ADP eurjchem-11 65 96     SPACE eurjchem-11 65 97 3.5 3.5 NUM eurjchem-11 65 98 , , PUNCT eurjchem-11 65 99     SPACE eurjchem-11 65 100 the the DET eurjchem-11 65 101     SPACE eurjchem-11 65 102 unknown unknown NOUN eurjchem-11 65 103     SPACE eurjchem-11 65 104 impurity‐1 impurity‐1 PRON eurjchem-11 65 105     SPACE eurjchem-11 65 106 was be AUX eurjchem-11 65 107     SPACE eurjchem-11 65 108 still still ADV eurjchem-11 65 109     SPACE eurjchem-11 65 110 merged merge VERB eurjchem-11 65 111     SPACE eurjchem-11 65 112 with with ADP eurjchem-11 65 113     SPACE eurjchem-11 65 114 the the DET eurjchem-11 65 115     SPACE eurjchem-11 65 116 dcpp dcpp NOUN eurjchem-11 65 117     SPACE eurjchem-11 65 118 impurity impurity NOUN eurjchem-11 65 119 . . PUNCT eurjchem-11 65 120     SPACE eurjchem-11 65 121 at at ADP eurjchem-11 65 122     SPACE eurjchem-11 65 123 ph ph NOUN eurjchem-11 65 124     SPACE eurjchem-11 65 125 2.5 2.5 NUM eurjchem-11 65 126 , , PUNCT eurjchem-11 65 127     SPACE eurjchem-11 65 128 all all DET eurjchem-11 65 129     SPACE eurjchem-11 65 130 the the DET eurjchem-11 65 131     SPACE eurjchem-11 65 132 known know VERB eurjchem-11 65 133     SPACE eurjchem-11 65 134 impurities impurity NOUN eurjchem-11 65 135     SPACE eurjchem-11 65 136 and and CCONJ eurjchem-11 65 137     SPACE eurjchem-11 65 138 the the DET eurjchem-11 65 139     SPACE eurjchem-11 65 140 degradants degradant NOUN eurjchem-11 65 141     SPACE eurjchem-11 65 142 were be AUX eurjchem-11 65 143     SPACE eurjchem-11 65 144 well well ADV eurjchem-11 65 145     SPACE eurjchem-11 65 146 separated separate VERB eurjchem-11 65 147 . . PUNCT eurjchem-11 65 148     SPACE eurjchem-11 65 149 thus thus ADV eurjchem-11 65 150 , , PUNCT eurjchem-11 65 151     SPACE eurjchem-11 65 152 ph ph VERB eurjchem-11 65 153     SPACE eurjchem-11 65 154 2.5 2.5 NUM eurjchem-11 65 155     SPACE eurjchem-11 65 156 was be AUX eurjchem-11 65 157     SPACE eurjchem-11 65 158 selected select VERB eurjchem-11 65 159     SPACE eurjchem-11 65 160 for for ADP eurjchem-11 65 161     SPACE eurjchem-11 65 162 separation separation NOUN eurjchem-11 65 163     SPACE eurjchem-11 65 164 process process NOUN eurjchem-11 65 165 . . PUNCT eurjchem-11 65 166       SPACE eurjchem-11 65 167 to to PART eurjchem-11 65 168     SPACE eurjchem-11 65 169 optimize optimize VERB eurjchem-11 65 170     SPACE eurjchem-11 65 171 the the DET eurjchem-11 65 172     SPACE eurjchem-11 65 173 organic organic ADJ eurjchem-11 65 174     SPACE eurjchem-11 65 175 modifier modifier NOUN eurjchem-11 65 176 , , PUNCT eurjchem-11 65 177     SPACE eurjchem-11 65 178 initially initially ADV eurjchem-11 65 179     SPACE eurjchem-11 65 180 a a DET eurjchem-11 65 181     SPACE eurjchem-11 65 182 100 100 NUM eurjchem-11 65 183 % % NOUN eurjchem-11 65 184     SPACE eurjchem-11 65 185 meoh meoh PROPN eurjchem-11 65 186     SPACE eurjchem-11 65 187 was be AUX eurjchem-11 65 188     SPACE eurjchem-11 65 189 attempted attempt VERB eurjchem-11 65 190 . . PUNCT eurjchem-11 65 191     SPACE eurjchem-11 66 1 however however ADV eurjchem-11 66 2 , , PUNCT eurjchem-11 66 3     SPACE eurjchem-11 66 4 this this DET eurjchem-11 66 5     SPACE eurjchem-11 66 6 100 100 NUM eurjchem-11 66 7 % % NOUN eurjchem-11 66 8     SPACE eurjchem-11 66 9 meoh meoh PROPN eurjchem-11 66 10     SPACE eurjchem-11 66 11 was be AUX eurjchem-11 66 12     SPACE eurjchem-11 66 13 unable unable ADJ eurjchem-11 66 14     SPACE eurjchem-11 66 15 to to PART eurjchem-11 66 16     SPACE eurjchem-11 66 17 elute elute VERB eurjchem-11 66 18     SPACE eurjchem-11 66 19 non‐polar non‐polar NOUN eurjchem-11 66 20     SPACE eurjchem-11 66 21 impurities impurity NOUN eurjchem-11 66 22     SPACE eurjchem-11 66 23 ( ( PUNCT eurjchem-11 66 24 apr‐1 apr‐1 NOUN eurjchem-11 66 25     SPACE eurjchem-11 66 26 and and CCONJ eurjchem-11 66 27     SPACE eurjchem-11 66 28 n‐bdq n‐bdq PROPN eurjchem-11 66 29 ) ) PUNCT eurjchem-11 66 30 . . PUNCT eurjchem-11 66 31     SPACE eurjchem-11 67 1 to to PART eurjchem-11 67 2     SPACE eurjchem-11 67 3 elute elute VERB eurjchem-11 67 4     SPACE eurjchem-11 67 5 these these PRON eurjchem-11 67 6     SPACE eurjchem-11 67 7 non‐ non‐ ADV eurjchem-11 67 8 polar polar ADJ eurjchem-11 67 9     SPACE eurjchem-11 67 10 impurities impurity NOUN eurjchem-11 67 11 , , PUNCT eurjchem-11 67 12     SPACE eurjchem-11 67 13 mixtures mixture NOUN eurjchem-11 67 14     SPACE eurjchem-11 67 15 of of ADP eurjchem-11 67 16     SPACE eurjchem-11 67 17 different different ADJ eurjchem-11 67 18     SPACE eurjchem-11 67 19 ratios ratio NOUN eurjchem-11 67 20     SPACE eurjchem-11 67 21 of of ADP eurjchem-11 67 22     SPACE eurjchem-11 67 23 acn acn PROPN eurjchem-11 67 24     SPACE eurjchem-11 67 25 and and CCONJ eurjchem-11 67 26     SPACE eurjchem-11 67 27 meoh meoh PROPN eurjchem-11 67 28     SPACE eurjchem-11 67 29 have have AUX eurjchem-11 67 30     SPACE eurjchem-11 67 31 been be AUX eurjchem-11 67 32     SPACE eurjchem-11 67 33 used use VERB eurjchem-11 67 34     SPACE eurjchem-11 67 35 and and CCONJ eurjchem-11 67 36     SPACE eurjchem-11 67 37 lead lead NOUN eurjchem-11 67 38     SPACE eurjchem-11 67 39 to to ADP eurjchem-11 67 40     SPACE eurjchem-11 67 41 a a DET eurjchem-11 67 42     SPACE eurjchem-11 67 43 better well ADJ eurjchem-11 67 44     SPACE eurjchem-11 67 45 separation separation NOUN eurjchem-11 67 46 . . PUNCT eurjchem-11 67 47     SPACE eurjchem-11 68 1 the the DET eurjchem-11 68 2     SPACE eurjchem-11 68 3 different different ADJ eurjchem-11 68 4     SPACE eurjchem-11 68 5 flow flow NOUN eurjchem-11 68 6     SPACE eurjchem-11 68 7 rates rate NOUN eurjchem-11 68 8     SPACE eurjchem-11 68 9 from from ADP eurjchem-11 68 10     SPACE eurjchem-11 68 11 0.8 0.8 NUM eurjchem-11 68 12     SPACE eurjchem-11 68 13 to to ADP eurjchem-11 68 14     SPACE eurjchem-11 68 15 1.3 1.3 NUM eurjchem-11 68 16     SPACE eurjchem-11 68 17 ml ml NOUN eurjchem-11 68 18 / / SYM eurjchem-11 68 19 min min NOUN eurjchem-11 68 20     SPACE eurjchem-11 68 21 at at ADP eurjchem-11 68 22     SPACE eurjchem-11 68 23 the the DET eurjchem-11 68 24     SPACE eurjchem-11 68 25 intervals interval NOUN eurjchem-11 68 26     SPACE eurjchem-11 68 27 of of ADP eurjchem-11 68 28     SPACE eurjchem-11 68 29 0.1 0.1 NUM eurjchem-11 68 30     SPACE eurjchem-11 68 31 ml ml NOUN eurjchem-11 68 32 / / SYM eurjchem-11 68 33 min min NOUN eurjchem-11 68 34     SPACE eurjchem-11 68 35 have have AUX eurjchem-11 68 36     SPACE eurjchem-11 68 37 been be AUX eurjchem-11 68 38     SPACE eurjchem-11 68 39 tried try VERB eurjchem-11 68 40 . . PUNCT eurjchem-11 68 41     SPACE eurjchem-11 68 42 sharp sharp ADJ eurjchem-11 68 43     SPACE eurjchem-11 68 44 peaks peak NOUN eurjchem-11 68 45     SPACE eurjchem-11 68 46 with with ADP eurjchem-11 68 47     SPACE eurjchem-11 68 48 good good ADJ eurjchem-11 68 49     SPACE eurjchem-11 68 50 resolution resolution NOUN eurjchem-11 68 51     SPACE eurjchem-11 68 52 were be AUX eurjchem-11 68 53     SPACE eurjchem-11 68 54 attained attain VERB eurjchem-11 68 55     SPACE eurjchem-11 68 56 using use VERB eurjchem-11 68 57     SPACE eurjchem-11 68 58 1.0 1.0 NUM eurjchem-11 68 59     SPACE eurjchem-11 68 60 ml ml NOUN eurjchem-11 68 61 / / SYM eurjchem-11 68 62 min min NOUN eurjchem-11 68 63 . . PROPN eurjchem-11 68 64     SPACE eurjchem-11 68 65 a a DET eurjchem-11 68 66     SPACE eurjchem-11 68 67 successful successful ADJ eurjchem-11 68 68     SPACE eurjchem-11 68 69 gradient gradient NOUN eurjchem-11 68 70     SPACE eurjchem-11 68 71 run run NOUN eurjchem-11 68 72     SPACE eurjchem-11 68 73 ( ( PUNCT eurjchem-11 68 74 mentioned mention VERB eurjchem-11 68 75     SPACE eurjchem-11 68 76 in in ADP eurjchem-11 68 77     SPACE eurjchem-11 68 78 the the DET eurjchem-11 68 79     SPACE eurjchem-11 68 80 experimental experimental ADJ eurjchem-11 68 81     SPACE eurjchem-11 68 82 section section NOUN eurjchem-11 68 83 ) ) PUNCT eurjchem-11 68 84     SPACE eurjchem-11 68 85 was be AUX eurjchem-11 68 86     SPACE eurjchem-11 68 87 employed employ VERB eurjchem-11 68 88     SPACE eurjchem-11 68 89 to to PART eurjchem-11 68 90     SPACE eurjchem-11 68 91 resolve resolve VERB eurjchem-11 68 92     SPACE eurjchem-11 68 93 all all DET eurjchem-11 68 94     SPACE eurjchem-11 68 95 the the DET eurjchem-11 68 96     SPACE eurjchem-11 68 97 known know VERB eurjchem-11 68 98     SPACE eurjchem-11 68 99 impurities impurity NOUN eurjchem-11 68 100     SPACE eurjchem-11 68 101 and and CCONJ eurjchem-11 68 102     SPACE eurjchem-11 68 103 the the DET eurjchem-11 68 104     SPACE eurjchem-11 68 105 degradation degradation NOUN eurjchem-11 68 106     SPACE eurjchem-11 68 107 products product NOUN eurjchem-11 68 108     SPACE eurjchem-11 68 109 which which PRON eurjchem-11 68 110     SPACE eurjchem-11 68 111 were be AUX eurjchem-11 68 112     SPACE eurjchem-11 68 113 formed form VERB eurjchem-11 68 114     SPACE eurjchem-11 68 115 during during ADP eurjchem-11 68 116     SPACE eurjchem-11 68 117 degradation degradation NOUN eurjchem-11 68 118 . . PUNCT eurjchem-11 68 119     SPACE eurjchem-11 69 1 the the DET eurjchem-11 69 2     SPACE eurjchem-11 69 3 optimized optimize VERB eurjchem-11 69 4     SPACE eurjchem-11 69 5 injection injection NOUN eurjchem-11 69 6     SPACE eurjchem-11 69 7 volume volume NOUN eurjchem-11 69 8     SPACE eurjchem-11 69 9 and and CCONJ eurjchem-11 69 10     SPACE eurjchem-11 69 11 detection detection NOUN eurjchem-11 69 12     SPACE eurjchem-11 69 13 wavelength wavelength NOUN eurjchem-11 69 14     SPACE eurjchem-11 69 15 were be AUX eurjchem-11 69 16     SPACE eurjchem-11 69 17 10 10 NUM eurjchem-11 69 18     SPACE eurjchem-11 69 19 μl μl ADJ eurjchem-11 69 20     SPACE eurjchem-11 69 21 and and CCONJ eurjchem-11 69 22     SPACE eurjchem-11 69 23 248 248 NUM eurjchem-11 69 24     SPACE eurjchem-11 69 25 nm nm NOUN eurjchem-11 69 26 , , PUNCT eurjchem-11 69 27     SPACE eurjchem-11 69 28 respectively respectively ADV eurjchem-11 69 29 . . PUNCT eurjchem-11 69 30           SPACE eurjchem-11 69 31 3.2 3.2 NUM eurjchem-11 69 32 . . PUNCT eurjchem-11 69 33     SPACE eurjchem-11 69 34 degradation degradation NOUN eurjchem-11 69 35     SPACE eurjchem-11 69 36 behavior behavior NOUN eurjchem-11 69 37         SPACE eurjchem-11 69 38 the the DET eurjchem-11 69 39     SPACE eurjchem-11 69 40 developed develop VERB eurjchem-11 69 41     SPACE eurjchem-11 69 42 lc‐ms lc‐ms AUX eurjchem-11 69 43     SPACE eurjchem-11 69 44 method method NOUN eurjchem-11 69 45     SPACE eurjchem-11 69 46 was be AUX eurjchem-11 69 47     SPACE eurjchem-11 69 48 used use VERB eurjchem-11 69 49     SPACE eurjchem-11 69 50 to to PART eurjchem-11 69 51     SPACE eurjchem-11 69 52 study study VERB eurjchem-11 69 53     SPACE eurjchem-11 69 54 degradation degradation NOUN eurjchem-11 69 55     SPACE eurjchem-11 69 56 behavior behavior NOUN eurjchem-11 69 57     SPACE eurjchem-11 69 58 of of ADP eurjchem-11 69 59     SPACE eurjchem-11 69 60 aripiprazole aripiprazole NOUN eurjchem-11 69 61     SPACE eurjchem-11 69 62 in in ADP eurjchem-11 69 63     SPACE eurjchem-11 69 64 its its PRON eurjchem-11 69 65     SPACE eurjchem-11 69 66 tablet tablet NOUN eurjchem-11 69 67     SPACE eurjchem-11 69 68 formulations formulation NOUN eurjchem-11 69 69     SPACE eurjchem-11 69 70 under under ADP eurjchem-11 69 71     SPACE eurjchem-11 69 72 various various ADJ eurjchem-11 69 73     SPACE eurjchem-11 69 74 stress stress NOUN eurjchem-11 69 75     SPACE eurjchem-11 69 76 conditions condition NOUN eurjchem-11 69 77     SPACE eurjchem-11 69 78 such such ADJ eurjchem-11 69 79     SPACE eurjchem-11 69 80 as as ADP eurjchem-11 69 81     SPACE eurjchem-11 69 82 thermal thermal ADJ eurjchem-11 69 83 , , PUNCT eurjchem-11 69 84     SPACE eurjchem-11 69 85 humidity humidity NOUN eurjchem-11 69 86 , , PUNCT eurjchem-11 69 87     SPACE eurjchem-11 69 88 photolytic photolytic ADJ eurjchem-11 69 89 , , PUNCT eurjchem-11 69 90     SPACE eurjchem-11 69 91 acidic acidic ADJ eurjchem-11 69 92 , , PUNCT eurjchem-11 69 93     SPACE eurjchem-11 69 94 basic basic NOUN eurjchem-11 69 95     SPACE eurjchem-11 69 96 and and CCONJ eurjchem-11 69 97     SPACE eurjchem-11 69 98 oxidation oxidation NOUN eurjchem-11 69 99     SPACE eurjchem-11 69 100 conditions condition NOUN eurjchem-11 69 101 . . PUNCT eurjchem-11 69 102     SPACE eurjchem-11 70 1 the the DET eurjchem-11 70 2     SPACE eurjchem-11 70 3 control control NOUN eurjchem-11 70 4     SPACE eurjchem-11 70 5 sample sample NOUN eurjchem-11 70 6     SPACE eurjchem-11 70 7 of of ADP eurjchem-11 70 8     SPACE eurjchem-11 70 9 aripiprazole aripiprazole NOUN eurjchem-11 70 10     SPACE eurjchem-11 70 11 showed show VERB eurjchem-11 70 12     SPACE eurjchem-11 70 13 only only ADV eurjchem-11 70 14     SPACE eurjchem-11 70 15 one one NUM eurjchem-11 70 16     SPACE eurjchem-11 70 17 major major ADJ eurjchem-11 70 18     SPACE eurjchem-11 70 19 peak peak NOUN eurjchem-11 70 20 , , PUNCT eurjchem-11 70 21     SPACE eurjchem-11 70 22 a a DET eurjchem-11 70 23     SPACE eurjchem-11 70 24 typical typical ADJ eurjchem-11 70 25     SPACE eurjchem-11 70 26 chromatogram chromatogram NOUN eurjchem-11 70 27     SPACE eurjchem-11 70 28 of of ADP eurjchem-11 70 29     SPACE eurjchem-11 70 30 control control NOUN eurjchem-11 70 31     SPACE eurjchem-11 70 32 tablet tablet NOUN eurjchem-11 70 33     SPACE eurjchem-11 70 34 sample sample NOUN eurjchem-11 70 35     SPACE eurjchem-11 70 36 was be AUX eurjchem-11 70 37     SPACE eurjchem-11 70 38 shown show VERB eurjchem-11 70 39     SPACE eurjchem-11 70 40 in in ADP eurjchem-11 70 41     SPACE eurjchem-11 70 42 figure figure NOUN eurjchem-11 70 43     SPACE eurjchem-11 70 44 2a 2a NUM eurjchem-11 70 45 . . PUNCT eurjchem-11 70 46     SPACE eurjchem-11 71 1 the the DET eurjchem-11 71 2     SPACE eurjchem-11 71 3 separation separation NOUN eurjchem-11 71 4     SPACE eurjchem-11 71 5 of of ADP eurjchem-11 71 6     SPACE eurjchem-11 71 7 aripiprazole aripiprazole NOUN eurjchem-11 71 8     SPACE eurjchem-11 71 9 from from ADP eurjchem-11 71 10     SPACE eurjchem-11 71 11 its its PRON eurjchem-11 71 12     SPACE eurjchem-11 71 13 known know VERB eurjchem-11 71 14     SPACE eurjchem-11 71 15 impurities impurity NOUN eurjchem-11 71 16     SPACE eurjchem-11 71 17 ( ( PUNCT eurjchem-11 71 18 spiked spiked ADJ eurjchem-11 71 19     SPACE eurjchem-11 71 20 solution solution NOUN eurjchem-11 71 21     SPACE eurjchem-11 71 22 of of ADP eurjchem-11 71 23     SPACE eurjchem-11 71 24 known know VERB eurjchem-11 71 25     SPACE eurjchem-11 71 26 impurities impurity NOUN eurjchem-11 71 27 ) ) PUNCT eurjchem-11 71 28     SPACE eurjchem-11 71 29 was be AUX eurjchem-11 71 30     SPACE eurjchem-11 71 31 shown show VERB eurjchem-11 71 32     SPACE eurjchem-11 71 33 in in ADP eurjchem-11 71 34     SPACE eurjchem-11 71 35 figure figure NOUN eurjchem-11 71 36     SPACE eurjchem-11 71 37 2b 2b NOUN eurjchem-11 71 38     SPACE eurjchem-11 71 39 and and CCONJ eurjchem-11 71 40     SPACE eurjchem-11 71 41 it it PRON eurjchem-11 71 42     SPACE eurjchem-11 71 43 can can AUX eurjchem-11 71 44     SPACE eurjchem-11 71 45 ensure ensure VERB eurjchem-11 71 46     SPACE eurjchem-11 71 47 that that SCONJ eurjchem-11 71 48     SPACE eurjchem-11 71 49 the the DET eurjchem-11 71 50     SPACE eurjchem-11 71 51 separation separation NOUN eurjchem-11 71 52     SPACE eurjchem-11 71 53 was be AUX eurjchem-11 71 54     SPACE eurjchem-11 71 55 achieved achieve VERB eurjchem-11 71 56     SPACE eurjchem-11 71 57 within within ADP eurjchem-11 71 58     SPACE eurjchem-11 71 59 45 45 NUM eurjchem-11 71 60     SPACE eurjchem-11 71 61 mins min NOUN eurjchem-11 71 62 . . PUNCT eurjchem-11 71 63           SPACE eurjchem-11 71 64 3.3 3.3 NUM eurjchem-11 71 65 . . PUNCT eurjchem-11 71 66     SPACE eurjchem-11 71 67 thermal thermal ADJ eurjchem-11 71 68     SPACE eurjchem-11 71 69 degradation degradation NOUN eurjchem-11 71 70         SPACE eurjchem-11 71 71 thermal thermal ADJ eurjchem-11 71 72     SPACE eurjchem-11 71 73 degradation degradation NOUN eurjchem-11 71 74     SPACE eurjchem-11 71 75 was be AUX eurjchem-11 71 76     SPACE eurjchem-11 71 77 carried carry VERB eurjchem-11 71 78     SPACE eurjchem-11 71 79 out out ADP eurjchem-11 71 80     SPACE eurjchem-11 71 81 by by ADP eurjchem-11 71 82     SPACE eurjchem-11 71 83 the the DET eurjchem-11 71 84     SPACE eurjchem-11 71 85 exposure exposure NOUN eurjchem-11 71 86     SPACE eurjchem-11 71 87 of of ADP eurjchem-11 71 88     SPACE eurjchem-11 71 89 aripiprazole aripiprazole NOUN eurjchem-11 71 90     SPACE eurjchem-11 71 91 tablet tablet NOUN eurjchem-11 71 92     SPACE eurjchem-11 71 93 powder powder NOUN eurjchem-11 71 94     SPACE eurjchem-11 71 95 at at ADP eurjchem-11 71 96     SPACE eurjchem-11 71 97 105 105 NUM eurjchem-11 71 98     SPACE eurjchem-11 71 99 oc oc NOUN eurjchem-11 71 100     SPACE eurjchem-11 71 101 for for ADP eurjchem-11 71 102     SPACE eurjchem-11 71 103 five five NUM eurjchem-11 71 104     SPACE eurjchem-11 71 105 days day NOUN eurjchem-11 71 106 . . PUNCT eurjchem-11 71 107     SPACE eurjchem-11 72 1 three three NUM eurjchem-11 72 2     SPACE eurjchem-11 72 3 major major ADJ eurjchem-11 72 4     SPACE eurjchem-11 72 5 degradation degradation NOUN eurjchem-11 72 6     SPACE eurjchem-11 72 7 products product NOUN eurjchem-11 72 8     SPACE eurjchem-11 72 9 were be AUX eurjchem-11 72 10     SPACE eurjchem-11 72 11 observed observe VERB eurjchem-11 72 12     SPACE eurjchem-11 72 13 within within ADP eurjchem-11 72 14     SPACE eurjchem-11 72 15 3 3 NUM eurjchem-11 72 16     SPACE eurjchem-11 72 17 days day NOUN eurjchem-11 72 18     SPACE eurjchem-11 72 19 at at ADP eurjchem-11 72 20     SPACE eurjchem-11 72 21 relative relative ADJ eurjchem-11 72 22     SPACE eurjchem-11 72 23 retention retention NOUN eurjchem-11 72 24     SPACE eurjchem-11 72 25 times time NOUN eurjchem-11 72 26     SPACE eurjchem-11 72 27 ( ( PUNCT eurjchem-11 72 28 rrt rrt NOUN eurjchem-11 72 29 ) ) PUNCT eurjchem-11 72 30     SPACE eurjchem-11 72 31 of of ADP eurjchem-11 72 32     SPACE eurjchem-11 72 33 0.45 0.45 NUM eurjchem-11 72 34 , , PUNCT eurjchem-11 72 35     SPACE eurjchem-11 72 36 1.06 1.06 NUM eurjchem-11 72 37     SPACE eurjchem-11 72 38 and and CCONJ eurjchem-11 72 39     SPACE eurjchem-11 72 40 1.14 1.14 NUM eurjchem-11 72 41     SPACE eurjchem-11 72 42 min min NOUN eurjchem-11 72 43     SPACE eurjchem-11 72 44 and and CCONJ eurjchem-11 72 45     SPACE eurjchem-11 72 46 the the DET eurjchem-11 72 47     SPACE eurjchem-11 72 48 corresponding corresponding ADJ eurjchem-11 72 49     SPACE eurjchem-11 72 50 chromatogram chromatogram PROPN eurjchem-11 72 51     SPACE eurjchem-11 72 52 is be AUX eurjchem-11 72 53     SPACE eurjchem-11 72 54 shown show VERB eurjchem-11 72 55     SPACE eurjchem-11 72 56 in in ADP eurjchem-11 72 57     SPACE eurjchem-11 72 58 figure figure NOUN eurjchem-11 72 59     SPACE eurjchem-11 72 60 3a 3a NUM eurjchem-11 72 61 . . PUNCT eurjchem-11 72 62     SPACE eurjchem-11 73 1 no no DET eurjchem-11 73 2     SPACE eurjchem-11 73 3 other other ADJ eurjchem-11 73 4     SPACE eurjchem-11 73 5 new new ADJ eurjchem-11 73 6     SPACE eurjchem-11 73 7 degradants degradant NOUN eurjchem-11 73 8     SPACE eurjchem-11 73 9 were be AUX eurjchem-11 73 10     SPACE eurjchem-11 73 11 formed form VERB eurjchem-11 73 12     SPACE eurjchem-11 73 13 between between ADP eurjchem-11 73 14     SPACE eurjchem-11 73 15 3–5 3–5 NUM eurjchem-11 73 16     SPACE eurjchem-11 73 17 days day NOUN eurjchem-11 73 18 . . PUNCT eurjchem-11 73 19               SPACE eurjchem-11 74 1 3.4 3.4 NUM eurjchem-11 74 2 . . PUNCT eurjchem-11 74 3     SPACE eurjchem-11 74 4 oxidative oxidative ADJ eurjchem-11 74 5     SPACE eurjchem-11 74 6 degradation degradation NOUN eurjchem-11 74 7         SPACE eurjchem-11 74 8 the the DET eurjchem-11 74 9     SPACE eurjchem-11 74 10 oxidative oxidative ADJ eurjchem-11 74 11     SPACE eurjchem-11 74 12 degradation degradation NOUN eurjchem-11 74 13     SPACE eurjchem-11 74 14 was be AUX eurjchem-11 74 15     SPACE eurjchem-11 74 16 performed perform VERB eurjchem-11 74 17     SPACE eurjchem-11 74 18 using use VERB eurjchem-11 74 19     SPACE eurjchem-11 74 20 30 30 NUM eurjchem-11 74 21 % % NOUN eurjchem-11 74 22     SPACE eurjchem-11 74 23 h2o2 h2o2 PROPN eurjchem-11 74 24 . . PROPN eurjchem-11 74 25     SPACE eurjchem-11 74 26 aripiprazole aripiprazole PROPN eurjchem-11 74 27     SPACE eurjchem-11 74 28 undergoes undergo VERB eurjchem-11 74 29     SPACE eurjchem-11 74 30 oxidative oxidative ADJ eurjchem-11 74 31     SPACE eurjchem-11 74 32 degradation degradation NOUN eurjchem-11 74 33     SPACE eurjchem-11 74 34 and and CCONJ eurjchem-11 74 35     SPACE eurjchem-11 74 36 forms form NOUN eurjchem-11 74 37     SPACE eurjchem-11 74 38 an an DET eurjchem-11 74 39     SPACE eurjchem-11 74 40 unknown unknown ADJ eurjchem-11 74 41     SPACE eurjchem-11 74 42 impurity impurity NOUN eurjchem-11 74 43     SPACE eurjchem-11 74 44 at at ADP eurjchem-11 74 45     SPACE eurjchem-11 74 46 rrt rrt NOUN eurjchem-11 74 47     SPACE eurjchem-11 74 48 1.06 1.06 NUM eurjchem-11 74 49     SPACE eurjchem-11 74 50 in in ADP eurjchem-11 74 51     SPACE eurjchem-11 74 52 major major ADJ eurjchem-11 74 53     SPACE eurjchem-11 74 54 quantities quantity NOUN eurjchem-11 74 55     SPACE eurjchem-11 74 56 ( ( PUNCT eurjchem-11 74 57 figure figure NOUN eurjchem-11 74 58     SPACE eurjchem-11 74 59 3b 3b NUM eurjchem-11 74 60 ) ) PUNCT eurjchem-11 74 61 . . PUNCT eurjchem-11 74 62         SPACE eurjchem-11 75 1 3.5 3.5 NUM eurjchem-11 75 2 . . PUNCT eurjchem-11 75 3     SPACE eurjchem-11 75 4 humidity humidity NOUN eurjchem-11 75 5     SPACE eurjchem-11 75 6 degradation degradation NOUN eurjchem-11 75 7         SPACE eurjchem-11 75 8 the the DET eurjchem-11 75 9     SPACE eurjchem-11 75 10 aripiprazole aripiprazole NOUN eurjchem-11 75 11     SPACE eurjchem-11 75 12 tablet tablet NOUN eurjchem-11 75 13     SPACE eurjchem-11 75 14 powder powder NOUN eurjchem-11 75 15     SPACE eurjchem-11 75 16 was be AUX eurjchem-11 75 17     SPACE eurjchem-11 75 18 exposed expose VERB eurjchem-11 75 19     SPACE eurjchem-11 75 20 to to ADP eurjchem-11 75 21     SPACE eurjchem-11 75 22 90 90 NUM eurjchem-11 75 23 % % NOUN eurjchem-11 75 24     SPACE eurjchem-11 75 25 of of ADP eurjchem-11 75 26     SPACE eurjchem-11 75 27 relative relative ADJ eurjchem-11 75 28     SPACE eurjchem-11 75 29 humidity humidity NOUN eurjchem-11 75 30     SPACE eurjchem-11 75 31 at at ADP eurjchem-11 75 32     SPACE eurjchem-11 75 33 room room NOUN eurjchem-11 75 34     SPACE eurjchem-11 75 35 temperature temperature NOUN eurjchem-11 75 36     SPACE eurjchem-11 75 37 up up ADV eurjchem-11 75 38     SPACE eurjchem-11 75 39 to to ADP eurjchem-11 75 40     SPACE eurjchem-11 75 41 7 7 NUM eurjchem-11 75 42     SPACE eurjchem-11 75 43 days day NOUN eurjchem-11 75 44 . . PUNCT eurjchem-11 75 45     SPACE eurjchem-11 76 1 it it PRON eurjchem-11 76 2     SPACE eurjchem-11 76 3 has have AUX eurjchem-11 76 4     SPACE eurjchem-11 76 5 been be AUX eurjchem-11 76 6     SPACE eurjchem-11 76 7 observed observe VERB eurjchem-11 76 8     SPACE eurjchem-11 76 9 that that SCONJ eurjchem-11 76 10     SPACE eurjchem-11 76 11 there there PRON eurjchem-11 76 12     SPACE eurjchem-11 76 13 was be AUX eurjchem-11 76 14     SPACE eurjchem-11 76 15 no no DET eurjchem-11 76 16     SPACE eurjchem-11 76 17 significant significant ADJ eurjchem-11 76 18     SPACE eurjchem-11 76 19 degradation degradation NOUN eurjchem-11 76 20     SPACE eurjchem-11 76 21 occurred occur VERB eurjchem-11 76 22     SPACE eurjchem-11 76 23 ( ( PUNCT eurjchem-11 76 24 figure figure NOUN eurjchem-11 76 25     SPACE eurjchem-11 76 26 3c 3c NUM eurjchem-11 76 27 ) ) PUNCT eurjchem-11 76 28 . . PUNCT eurjchem-11 76 29           SPACE eurjchem-11 77 1 3.6 3.6 NUM eurjchem-11 77 2 . . PUNCT eurjchem-11 77 3     SPACE eurjchem-11 77 4 photolytic photolytic ADJ eurjchem-11 77 5     SPACE eurjchem-11 77 6 degradation degradation NOUN eurjchem-11 77 7         SPACE eurjchem-11 77 8 the the DET eurjchem-11 77 9     SPACE eurjchem-11 77 10 photolytic photolytic ADJ eurjchem-11 77 11     SPACE eurjchem-11 77 12 conditions condition NOUN eurjchem-11 77 13     SPACE eurjchem-11 77 14 such such ADJ eurjchem-11 77 15     SPACE eurjchem-11 77 16 as as ADP eurjchem-11 77 17     SPACE eurjchem-11 77 18 1.2 1.2 NUM eurjchem-11 77 19     SPACE eurjchem-11 77 20 million million NUM eurjchem-11 77 21     SPACE eurjchem-11 77 22 lux lux NOUN eurjchem-11 77 23     SPACE eurjchem-11 77 24 hours hour NOUN eurjchem-11 77 25     SPACE eurjchem-11 77 26 and and CCONJ eurjchem-11 77 27     SPACE eurjchem-11 77 28 200 200 NUM eurjchem-11 77 29     SPACE eurjchem-11 77 30 whrs whrs NOUN eurjchem-11 77 31 / / SYM eurjchem-11 77 32 m2 m2 PROPN eurjchem-11 77 33     SPACE eurjchem-11 77 34 were be AUX eurjchem-11 77 35     SPACE eurjchem-11 77 36 applied apply VERB eurjchem-11 77 37     SPACE eurjchem-11 77 38 to to ADP eurjchem-11 77 39     SPACE eurjchem-11 77 40 aripiprazole aripiprazole NOUN eurjchem-11 77 41     SPACE eurjchem-11 77 42 tablets tablet NOUN eurjchem-11 77 43     SPACE eurjchem-11 77 44 for for ADP eurjchem-11 77 45     SPACE eurjchem-11 77 46 five five NUM eurjchem-11 77 47     SPACE eurjchem-11 77 48 days day NOUN eurjchem-11 77 49 . . PUNCT eurjchem-11 77 50     SPACE eurjchem-11 78 1 no no DET eurjchem-11 78 2     SPACE eurjchem-11 78 3 degradation degradation NOUN eurjchem-11 78 4     SPACE eurjchem-11 78 5 was be AUX eurjchem-11 78 6     SPACE eurjchem-11 78 7 observed observe VERB eurjchem-11 78 8     SPACE eurjchem-11 78 9 and and CCONJ eurjchem-11 78 10     SPACE eurjchem-11 78 11 the the DET eurjchem-11 78 12     SPACE eurjchem-11 78 13 represented represent VERB eurjchem-11 78 14     SPACE eurjchem-11 78 15 chromatogram chromatogram PROPN eurjchem-11 78 16     SPACE eurjchem-11 78 17 was be AUX eurjchem-11 78 18     SPACE eurjchem-11 78 19 shown show VERB eurjchem-11 78 20     SPACE eurjchem-11 78 21 in in ADP eurjchem-11 78 22     SPACE eurjchem-11 78 23 figure figure NOUN eurjchem-11 78 24     SPACE eurjchem-11 78 25 3d 3d NOUN eurjchem-11 78 26 . . PUNCT eurjchem-11 78 27         SPACE eurjchem-11 79 1 3.7 3.7 NUM eurjchem-11 79 2 . . PUNCT eurjchem-11 79 3     SPACE eurjchem-11 79 4 acid acid NOUN eurjchem-11 79 5     SPACE eurjchem-11 79 6 and and CCONJ eurjchem-11 79 7     SPACE eurjchem-11 79 8 base base NOUN eurjchem-11 79 9     SPACE eurjchem-11 79 10 degradations degradation NOUN eurjchem-11 79 11         SPACE eurjchem-11 79 12 the the DET eurjchem-11 79 13     SPACE eurjchem-11 79 14 acid acid NOUN eurjchem-11 79 15     SPACE eurjchem-11 79 16 and and CCONJ eurjchem-11 79 17     SPACE eurjchem-11 79 18 base base NOUN eurjchem-11 79 19     SPACE eurjchem-11 79 20 degradation degradation NOUN eurjchem-11 79 21     SPACE eurjchem-11 79 22 studies study NOUN eurjchem-11 79 23     SPACE eurjchem-11 79 24 were be AUX eurjchem-11 79 25     SPACE eurjchem-11 79 26 carried carry VERB eurjchem-11 79 27     SPACE eurjchem-11 79 28 out out ADP eurjchem-11 79 29       SPACE eurjchem-11 79 30 by by ADP eurjchem-11 79 31     SPACE eurjchem-11 79 32 adding add VERB eurjchem-11 79 33     SPACE eurjchem-11 79 34 5 5 NUM eurjchem-11 79 35     SPACE eurjchem-11 79 36 ml ml NOUN eurjchem-11 79 37     SPACE eurjchem-11 79 38 of of ADP eurjchem-11 79 39     SPACE eurjchem-11 79 40 5 5 NUM eurjchem-11 79 41     SPACE eurjchem-11 79 42 m m NOUN eurjchem-11 79 43     SPACE eurjchem-11 79 44 hcl hcl PROPN eurjchem-11 79 45     SPACE eurjchem-11 79 46 and and CCONJ eurjchem-11 79 47     SPACE eurjchem-11 79 48 5 5 NUM eurjchem-11 79 49     SPACE eurjchem-11 79 50 m m PRON eurjchem-11 79 51     SPACE eurjchem-11 79 52 naoh naoh NOUN eurjchem-11 79 53 , , PUNCT eurjchem-11 79 54     SPACE eurjchem-11 79 55 respectively respectively ADV eurjchem-11 79 56 . . PUNCT eurjchem-11 79 57     SPACE eurjchem-11 80 1 the the DET eurjchem-11 80 2     SPACE eurjchem-11 80 3 aripiprazole aripiprazole NOUN eurjchem-11 80 4     SPACE eurjchem-11 80 5 was be AUX eurjchem-11 80 6     SPACE eurjchem-11 80 7 found find VERB eurjchem-11 80 8     SPACE eurjchem-11 80 9 to to PART eurjchem-11 80 10     SPACE eurjchem-11 80 11 be be AUX eurjchem-11 80 12     SPACE eurjchem-11 80 13 stable stable ADJ eurjchem-11 80 14     SPACE eurjchem-11 80 15 under under ADP eurjchem-11 80 16     SPACE eurjchem-11 80 17 these these DET eurjchem-11 80 18     SPACE eurjchem-11 80 19 conditions condition NOUN eurjchem-11 80 20     SPACE eurjchem-11 80 21 and and CCONJ eurjchem-11 80 22     SPACE eurjchem-11 80 23 respective respective ADJ eurjchem-11 80 24     SPACE eurjchem-11 80 25 chromatograms chromatogram NOUN eurjchem-11 80 26     SPACE eurjchem-11 80 27 were be AUX eurjchem-11 80 28     SPACE eurjchem-11 80 29 shown show VERB eurjchem-11 80 30     SPACE eurjchem-11 80 31 in in ADP eurjchem-11 80 32     SPACE eurjchem-11 80 33 figure figure NOUN eurjchem-11 80 34     SPACE eurjchem-11 80 35 3e 3e NOUN eurjchem-11 80 36     SPACE eurjchem-11 80 37 and and CCONJ eurjchem-11 80 38     SPACE eurjchem-11 80 39 3f 3f NOUN eurjchem-11 80 40 , , PUNCT eurjchem-11 80 41     SPACE eurjchem-11 80 42 respectively respectively ADV eurjchem-11 80 43 . . PUNCT eurjchem-11 80 44     SPACE eurjchem-11 80 45 the the DET eurjchem-11 80 46     SPACE eurjchem-11 80 47 degradation degradation NOUN eurjchem-11 80 48     SPACE eurjchem-11 80 49 studies study NOUN eurjchem-11 80 50     SPACE eurjchem-11 80 51 reveal reveal VERB eurjchem-11 80 52     SPACE eurjchem-11 80 53 that that SCONJ eurjchem-11 80 54     SPACE eurjchem-11 80 55 the the DET eurjchem-11 80 56     SPACE eurjchem-11 80 57 aripiprazole aripiprazole NOUN eurjchem-11 80 58     SPACE eurjchem-11 80 59 was be AUX eurjchem-11 80 60     SPACE eurjchem-11 80 61 undergone undergone ADJ eurjchem-11 80 62     SPACE eurjchem-11 80 63 degradation degradation NOUN eurjchem-11 80 64     SPACE eurjchem-11 80 65 in in ADP eurjchem-11 80 66     SPACE eurjchem-11 80 67 thermal thermal ADJ eurjchem-11 80 68     SPACE eurjchem-11 80 69 and and CCONJ eurjchem-11 80 70     SPACE eurjchem-11 80 71 peroxide peroxide NOUN eurjchem-11 80 72     SPACE eurjchem-11 80 73 conditions condition NOUN eurjchem-11 80 74 . . PUNCT eurjchem-11 80 75     SPACE eurjchem-11 81 1 under under ADP eurjchem-11 81 2     SPACE eurjchem-11 81 3 these these DET eurjchem-11 81 4     SPACE eurjchem-11 81 5 degradation degradation NOUN eurjchem-11 81 6     SPACE eurjchem-11 81 7 conditions condition NOUN eurjchem-11 81 8 , , PUNCT eurjchem-11 81 9     SPACE eurjchem-11 81 10 aripiprazole aripiprazole NOUN eurjchem-11 81 11     SPACE eurjchem-11 81 12 was be AUX eurjchem-11 81 13     SPACE eurjchem-11 81 14 degraded degrade VERB eurjchem-11 81 15     SPACE eurjchem-11 81 16 up up ADP eurjchem-11 81 17     SPACE eurjchem-11 81 18 to to PART eurjchem-11 81 19     SPACE eurjchem-11 81 20 30 30 NUM eurjchem-11 81 21     SPACE eurjchem-11 81 22 % % NOUN eurjchem-11 81 23     SPACE eurjchem-11 81 24 and and CCONJ eurjchem-11 81 25     SPACE eurjchem-11 81 26 10 10 NUM eurjchem-11 81 27 % % NOUN eurjchem-11 81 28 , , PUNCT eurjchem-11 81 29     SPACE eurjchem-11 81 30 respectively respectively ADV eurjchem-11 81 31 . . PUNCT eurjchem-11 81 32     SPACE eurjchem-11 81 33 in in ADP eurjchem-11 81 34     SPACE eurjchem-11 81 35 peroxide peroxide NOUN eurjchem-11 81 36     SPACE eurjchem-11 81 37 degradation degradation NOUN eurjchem-11 81 38 , , PUNCT eurjchem-11 81 39     SPACE eurjchem-11 81 40 one one NUM eurjchem-11 81 41     SPACE eurjchem-11 81 42 degradation degradation NOUN eurjchem-11 81 43     SPACE eurjchem-11 81 44 impurity impurity NOUN eurjchem-11 81 45     SPACE eurjchem-11 81 46 formed form VERB eurjchem-11 81 47     SPACE eurjchem-11 81 48 at at ADP eurjchem-11 81 49     SPACE eurjchem-11 81 50 rrt rrt NOUN eurjchem-11 81 51     SPACE eurjchem-11 81 52 1.06 1.06 NUM eurjchem-11 81 53     SPACE eurjchem-11 81 54 was be AUX eurjchem-11 81 55     SPACE eurjchem-11 81 56 also also ADV eurjchem-11 81 57     SPACE eurjchem-11 81 58 observed observe VERB eurjchem-11 81 59     SPACE eurjchem-11 81 60 in in ADP eurjchem-11 81 61     SPACE eurjchem-11 81 62 thermal thermal ADJ eurjchem-11 81 63     SPACE eurjchem-11 81 64 degradation degradation NOUN eurjchem-11 81 65 . . PUNCT eurjchem-11 81 66     SPACE eurjchem-11 82 1 the the DET eurjchem-11 82 2     SPACE eurjchem-11 82 3 major major ADJ eurjchem-11 82 4     SPACE eurjchem-11 82 5 degradation degradation NOUN eurjchem-11 82 6     SPACE eurjchem-11 82 7 impurities impurity NOUN eurjchem-11 82 8     SPACE eurjchem-11 82 9 were be AUX eurjchem-11 82 10     SPACE eurjchem-11 82 11 detected detect VERB eurjchem-11 82 12     SPACE eurjchem-11 82 13 in in ADP eurjchem-11 82 14     SPACE eurjchem-11 82 15 thermal thermal ADJ eurjchem-11 82 16     SPACE eurjchem-11 82 17 condition condition NOUN eurjchem-11 82 18     SPACE eurjchem-11 82 19 within within ADP eurjchem-11 82 20     SPACE eurjchem-11 82 21 3 3 NUM eurjchem-11 82 22     SPACE eurjchem-11 82 23 days day NOUN eurjchem-11 82 24     SPACE eurjchem-11 82 25 of of ADP eurjchem-11 82 26     SPACE eurjchem-11 82 27 the the DET eurjchem-11 82 28     SPACE eurjchem-11 82 29 aripiprazole aripiprazole NOUN eurjchem-11 82 30     SPACE eurjchem-11 82 31 tablet tablet NOUN eurjchem-11 82 32     SPACE eurjchem-11 82 33 formulation formulation NOUN eurjchem-11 82 34 . . PUNCT eurjchem-11 82 35     SPACE eurjchem-11 83 1 no no DET eurjchem-11 83 2     SPACE eurjchem-11 83 3 other other ADJ eurjchem-11 83 4     SPACE eurjchem-11 83 5 new new ADJ eurjchem-11 83 6     SPACE eurjchem-11 83 7 degradants degradant NOUN eurjchem-11 83 8     SPACE eurjchem-11 83 9 were be AUX eurjchem-11 83 10     SPACE eurjchem-11 83 11 formed form VERB eurjchem-11 83 12     SPACE eurjchem-11 83 13 after after ADP eurjchem-11 83 14     SPACE eurjchem-11 83 15 3 3 NUM eurjchem-11 83 16     SPACE eurjchem-11 83 17 days day NOUN eurjchem-11 83 18 . . PUNCT eurjchem-11 83 19           SPACE eurjchem-11 84 1 3.8 3.8 NUM eurjchem-11 84 2 . . PUNCT eurjchem-11 84 3     SPACE eurjchem-11 84 4 mass mass ADJ eurjchem-11 84 5     SPACE eurjchem-11 84 6 accuracy accuracy NOUN eurjchem-11 84 7         SPACE eurjchem-11 84 8 the the DET eurjchem-11 84 9     SPACE eurjchem-11 84 10 difference difference NOUN eurjchem-11 84 11     SPACE eurjchem-11 84 12 between between ADP eurjchem-11 84 13     SPACE eurjchem-11 84 14 theoretical theoretical ADJ eurjchem-11 84 15     SPACE eurjchem-11 84 16 and and CCONJ eurjchem-11 84 17     SPACE eurjchem-11 84 18 experimental experimental ADJ eurjchem-11 84 19     SPACE eurjchem-11 84 20 masses masse NOUN eurjchem-11 84 21     SPACE eurjchem-11 84 22 is be AUX eurjchem-11 84 23     SPACE eurjchem-11 84 24 generally generally ADV eurjchem-11 84 25     SPACE eurjchem-11 84 26 expressed express VERB eurjchem-11 84 27     SPACE eurjchem-11 84 28 in in ADP eurjchem-11 84 29     SPACE eurjchem-11 84 30 terms term NOUN eurjchem-11 84 31     SPACE eurjchem-11 84 32 of of ADP eurjchem-11 84 33     SPACE eurjchem-11 84 34 mass mass ADJ eurjchem-11 84 35     SPACE eurjchem-11 84 36 accuracy accuracy NOUN eurjchem-11 84 37 . . PUNCT eurjchem-11 84 38     SPACE eurjchem-11 85 1 the the DET eurjchem-11 85 2     SPACE eurjchem-11 85 3 accurate accurate ADJ eurjchem-11 85 4     SPACE eurjchem-11 85 5 mass mass PROPN eurjchem-11 85 6     SPACE eurjchem-11 85 7 measurement measurement NOUN eurjchem-11 85 8     SPACE eurjchem-11 85 9 gives give VERB eurjchem-11 85 10     SPACE eurjchem-11 85 11 the the DET eurjchem-11 85 12     SPACE eurjchem-11 85 13 elemental elemental NOUN eurjchem-11 85 14     SPACE eurjchem-11 85 15 composition composition NOUN eurjchem-11 85 16     SPACE eurjchem-11 85 17 of of ADP eurjchem-11 85 18     SPACE eurjchem-11 85 19 the the DET eurjchem-11 85 20     SPACE eurjchem-11 85 21 parent parent NOUN eurjchem-11 85 22     SPACE eurjchem-11 85 23 and and CCONJ eurjchem-11 85 24     SPACE eurjchem-11 85 25 fragment fragment NOUN eurjchem-11 85 26     SPACE eurjchem-11 85 27 ions ion NOUN eurjchem-11 85 28     SPACE eurjchem-11 85 29 and and CCONJ eurjchem-11 85 30     SPACE eurjchem-11 85 31 was be AUX eurjchem-11 85 32     SPACE eurjchem-11 85 33 used use VERB eurjchem-11 85 34     SPACE eurjchem-11 85 35 to to PART eurjchem-11 85 36     SPACE eurjchem-11 85 37 identify identify VERB eurjchem-11 85 38     SPACE eurjchem-11 85 39 unknown unknown ADJ eurjchem-11 85 40     SPACE eurjchem-11 85 41 species specie NOUN eurjchem-11 85 42 . . PUNCT eurjchem-11 85 43     SPACE eurjchem-11 86 1 qtof‐ms qtof‐ms PRON eurjchem-11 86 2     SPACE eurjchem-11 86 3 permits permit VERB eurjchem-11 86 4     SPACE eurjchem-11 86 5 ms ms PROPN eurjchem-11 86 6 / / SYM eurjchem-11 86 7 ms ms PROPN eurjchem-11 86 8     SPACE eurjchem-11 86 9 analysis analysis NOUN eurjchem-11 86 10     SPACE eurjchem-11 86 11 and and CCONJ eurjchem-11 86 12     SPACE eurjchem-11 86 13 provides provide VERB eurjchem-11 86 14     SPACE eurjchem-11 86 15 accurate accurate ADJ eurjchem-11 86 16     SPACE eurjchem-11 86 17 masses masse NOUN eurjchem-11 86 18     SPACE eurjchem-11 86 19 for for ADP eurjchem-11 86 20     SPACE eurjchem-11 86 21 both both DET eurjchem-11 86 22     SPACE eurjchem-11 86 23 precursor precursor NOUN eurjchem-11 86 24     SPACE eurjchem-11 86 25 and and CCONJ eurjchem-11 86 26     SPACE eurjchem-11 86 27 product product NOUN eurjchem-11 86 28     SPACE eurjchem-11 86 29 ions ion NOUN eurjchem-11 86 30 , , PUNCT eurjchem-11 86 31     SPACE eurjchem-11 86 32 reddy reddy PROPN eurjchem-11 86 33     SPACE eurjchem-11 86 34 et et PROPN eurjchem-11 86 35     SPACE eurjchem-11 86 36 al al PROPN eurjchem-11 86 37 . . PROPN eurjchem-11 86 38     SPACE eurjchem-11 86 39 / / SYM eurjchem-11 86 40     SPACE eurjchem-11 86 41 european european ADJ eurjchem-11 86 42     SPACE eurjchem-11 86 43 journal journal NOUN eurjchem-11 86 44     SPACE eurjchem-11 86 45 of of ADP eurjchem-11 86 46     SPACE eurjchem-11 86 47 chemistry chemistry NOUN eurjchem-11 86 48     SPACE eurjchem-11 86 49 1 1 NUM eurjchem-11 86 50     SPACE eurjchem-11 86 51 ( ( PUNCT eurjchem-11 86 52 1 1 NUM eurjchem-11 86 53 ) ) PUNCT eurjchem-11 86 54     SPACE eurjchem-11 86 55 ( ( PUNCT eurjchem-11 86 56 2010 2010 NUM eurjchem-11 86 57 ) ) PUNCT eurjchem-11 86 58     SPACE eurjchem-11 87 1 20­27 20­27 NUM eurjchem-11 87 2     SPACE eurjchem-11 87 3 23 23 NUM eurjchem-11 87 4             SPACE eurjchem-11 87 5 ( ( PUNCT eurjchem-11 87 6 a a NOUN eurjchem-11 87 7 ) ) PUNCT eurjchem-11 87 8       SPACE eurjchem-11 87 9 ( ( PUNCT eurjchem-11 87 10 b b NOUN eurjchem-11 87 11 ) ) PUNCT eurjchem-11 87 12       SPACE eurjchem-11 87 13 ( ( PUNCT eurjchem-11 87 14 c c NOUN eurjchem-11 87 15 ) ) PUNCT eurjchem-11 87 16           SPACE eurjchem-11 87 17 ( ( PUNCT eurjchem-11 87 18 d d NOUN eurjchem-11 87 19 ) ) PUNCT eurjchem-11 87 20       SPACE eurjchem-11 87 21 ( ( PUNCT eurjchem-11 87 22 e e NOUN eurjchem-11 87 23 ) ) PUNCT eurjchem-11 87 24       SPACE eurjchem-11 87 25 ( ( PUNCT eurjchem-11 87 26 f f X eurjchem-11 87 27 ) ) PUNCT eurjchem-11 87 28         SPACE eurjchem-11 87 29 figure figure NOUN eurjchem-11 87 30     SPACE eurjchem-11 87 31 3 3 NUM eurjchem-11 87 32 . . PUNCT eurjchem-11 87 33     SPACE eurjchem-11 87 34 thermal thermal ADJ eurjchem-11 87 35     SPACE eurjchem-11 87 36 ( ( PUNCT eurjchem-11 87 37 a a NOUN eurjchem-11 87 38 ) ) PUNCT eurjchem-11 87 39 , , PUNCT eurjchem-11 87 40     SPACE eurjchem-11 87 41 peroxide peroxide NOUN eurjchem-11 87 42     SPACE eurjchem-11 87 43 ( ( PUNCT eurjchem-11 87 44 b b NOUN eurjchem-11 87 45 ) ) PUNCT eurjchem-11 87 46 , , PUNCT eurjchem-11 87 47     SPACE eurjchem-11 87 48 humidity humidity NOUN eurjchem-11 87 49     SPACE eurjchem-11 87 50 ( ( PUNCT eurjchem-11 87 51 c c NOUN eurjchem-11 87 52 ) ) PUNCT eurjchem-11 87 53 , , PUNCT eurjchem-11 87 54     SPACE eurjchem-11 87 55 photolytic photolytic NOUN eurjchem-11 87 56     SPACE eurjchem-11 87 57 ( ( PUNCT eurjchem-11 87 58 d d NOUN eurjchem-11 87 59 ) ) PUNCT eurjchem-11 87 60 , , PUNCT eurjchem-11 87 61     SPACE eurjchem-11 87 62 acid acid NOUN eurjchem-11 87 63     SPACE eurjchem-11 87 64 ( ( PUNCT eurjchem-11 87 65 e e NOUN eurjchem-11 87 66 ) ) PUNCT eurjchem-11 87 67     SPACE eurjchem-11 87 68 and and CCONJ eurjchem-11 87 69     SPACE eurjchem-11 87 70 base base NOUN eurjchem-11 87 71     SPACE eurjchem-11 87 72 ( ( PUNCT eurjchem-11 87 73 f f NOUN eurjchem-11 87 74 ) ) PUNCT eurjchem-11 87 75     SPACE eurjchem-11 87 76 degradation degradation NOUN eurjchem-11 87 77     SPACE eurjchem-11 87 78 chromatograms chromatogram NOUN eurjchem-11 87 79     SPACE eurjchem-11 87 80 of of ADP eurjchem-11 87 81     SPACE eurjchem-11 87 82 aripiprazole aripiprazole NOUN eurjchem-11 87 83     SPACE eurjchem-11 87 84 tablet tablet NOUN eurjchem-11 87 85     SPACE eurjchem-11 87 86 sample sample NOUN eurjchem-11 87 87 . . PUNCT eurjchem-11 87 88         SPACE eurjchem-11 88 1 24 24 NUM eurjchem-11 88 2     SPACE eurjchem-11 88 3 reddy reddy PROPN eurjchem-11 88 4     SPACE eurjchem-11 88 5 et et PROPN eurjchem-11 88 6     SPACE eurjchem-11 88 7 al al PROPN eurjchem-11 88 8 . . PROPN eurjchem-11 88 9     SPACE eurjchem-11 88 10 / / SYM eurjchem-11 88 11     SPACE eurjchem-11 88 12 european european ADJ eurjchem-11 88 13     SPACE eurjchem-11 88 14 journal journal NOUN eurjchem-11 88 15     SPACE eurjchem-11 88 16 of of ADP eurjchem-11 88 17     SPACE eurjchem-11 88 18 chemistry chemistry NOUN eurjchem-11 88 19     SPACE eurjchem-11 88 20 1 1 NUM eurjchem-11 88 21     SPACE eurjchem-11 88 22 ( ( PUNCT eurjchem-11 88 23 1 1 NUM eurjchem-11 88 24 ) ) PUNCT eurjchem-11 88 25     SPACE eurjchem-11 88 26 ( ( PUNCT eurjchem-11 88 27 2010 2010 NUM eurjchem-11 88 28 ) ) PUNCT eurjchem-11 88 29     SPACE eurjchem-11 88 30 20­27 20­27 NUM eurjchem-11 88 31         SPACE eurjchem-11 88 32 table table NOUN eurjchem-11 88 33     SPACE eurjchem-11 88 34 2 2 NUM eurjchem-11 88 35 . . PUNCT eurjchem-11 88 36     SPACE eurjchem-11 88 37 elemental elemental ADJ eurjchem-11 88 38     SPACE eurjchem-11 88 39 composition composition NOUN eurjchem-11 88 40     SPACE eurjchem-11 88 41 and and CCONJ eurjchem-11 88 42     SPACE eurjchem-11 88 43 accurate accurate ADJ eurjchem-11 88 44     SPACE eurjchem-11 88 45 mass mass PROPN eurjchem-11 88 46     SPACE eurjchem-11 88 47 measurement measurement NOUN eurjchem-11 88 48     SPACE eurjchem-11 88 49 of of ADP eurjchem-11 88 50     SPACE eurjchem-11 88 51 precursor precursor NOUN eurjchem-11 88 52     SPACE eurjchem-11 88 53 ions ion NOUN eurjchem-11 88 54     SPACE eurjchem-11 88 55 of of ADP eurjchem-11 88 56     SPACE eurjchem-11 88 57 aripiprazole aripiprazole NOUN eurjchem-11 88 58     SPACE eurjchem-11 88 59 and and CCONJ eurjchem-11 88 60     SPACE eurjchem-11 88 61 its its PRON eurjchem-11 88 62     SPACE eurjchem-11 88 63 unknown unknown ADJ eurjchem-11 88 64     SPACE eurjchem-11 88 65 impurities impurity NOUN eurjchem-11 88 66     SPACE eurjchem-11 88 67 in in ADP eurjchem-11 88 68     SPACE eurjchem-11 88 69 the the DET eurjchem-11 88 70     SPACE eurjchem-11 88 71 mass mass NOUN eurjchem-11 88 72     SPACE eurjchem-11 88 73 spectrum spectrum NOUN eurjchem-11 88 74     SPACE eurjchem-11 88 75 of of ADP eurjchem-11 88 76     SPACE eurjchem-11 88 77 thermal thermal ADJ eurjchem-11 88 78     SPACE eurjchem-11 88 79 degradation degradation NOUN eurjchem-11 88 80     SPACE eurjchem-11 88 81 sample sample NOUN eurjchem-11 88 82 . . PUNCT eurjchem-11 88 83     SPACE eurjchem-11 88 84 product product NOUN eurjchem-11 88 85     SPACE eurjchem-11 88 86 rrt rrt NOUN eurjchem-11 88 87     SPACE eurjchem-11 88 88 elemental elemental ADJ eurjchem-11 88 89     SPACE eurjchem-11 88 90 composition composition NOUN eurjchem-11 88 91     SPACE eurjchem-11 88 92 theoretical theoretical ADJ eurjchem-11 88 93     SPACE eurjchem-11 88 94 mass mass PROPN eurjchem-11 88 95     SPACE eurjchem-11 88 96 ( ( PUNCT eurjchem-11 88 97 m m PROPN eurjchem-11 88 98 / / SYM eurjchem-11 88 99 z z NOUN eurjchem-11 88 100 ) ) PUNCT eurjchem-11 88 101     SPACE eurjchem-11 88 102 experimental experimental ADJ eurjchem-11 88 103     SPACE eurjchem-11 88 104 mass mass PROPN eurjchem-11 88 105     SPACE eurjchem-11 88 106 ( ( PUNCT eurjchem-11 88 107 m m PROPN eurjchem-11 88 108 / / SYM eurjchem-11 88 109 z z NOUN eurjchem-11 88 110 ) ) PUNCT eurjchem-11 88 111     SPACE eurjchem-11 88 112 mass mass ADJ eurjchem-11 88 113     SPACE eurjchem-11 88 114 difference difference NOUN eurjchem-11 88 115     SPACE eurjchem-11 88 116 error error NOUN eurjchem-11 88 117     SPACE eurjchem-11 88 118 ( ( PUNCT eurjchem-11 88 119 ppm ppm NOUN eurjchem-11 88 120 ) ) PUNCT eurjchem-11 88 121     SPACE eurjchem-11 88 122 aripiprazole aripiprazole NOUN eurjchem-11 88 123     SPACE eurjchem-11 88 124 1.00 1.00 NUM eurjchem-11 88 125     SPACE eurjchem-11 88 126 c23h28cl2n3o2 c23h28cl2n3o2 NOUN eurjchem-11 88 127     SPACE eurjchem-11 88 128 448.1559 448.1559 NUM eurjchem-11 88 129 448.1557 448.1557 NUM eurjchem-11 88 130 0.0002 0.0002 NUM eurjchem-11 88 131     SPACE eurjchem-11 88 132 0.4 0.4 NUM eurjchem-11 88 133 unknown unknown ADJ eurjchem-11 88 134     SPACE eurjchem-11 88 135 imp‐1 imp‐1 NOUN eurjchem-11 88 136     SPACE eurjchem-11 88 137 0.45 0.45 NUM eurjchem-11 88 138     SPACE eurjchem-11 88 139 c14 c14 NOUN eurjchem-11 88 140     SPACE eurjchem-11 88 141 h19 h19 PROPN eurjchem-11 88 142     SPACE eurjchem-11 88 143 cl2 cl2 NOUN eurjchem-11 88 144     SPACE eurjchem-11 88 145 n2 n2 NOUN eurjchem-11 88 146     SPACE eurjchem-11 88 147 285.0925 285.0925 NUM eurjchem-11 88 148 285.0921 285.0921 NUM eurjchem-11 88 149 0.0004 0.0004 NUM eurjchem-11 88 150     SPACE eurjchem-11 88 151 1.4 1.4 NUM eurjchem-11 88 152 unknown unknown ADJ eurjchem-11 88 153     SPACE eurjchem-11 88 154 imp‐2 imp‐2 ADP eurjchem-11 88 155     SPACE eurjchem-11 88 156 1.06 1.06 NUM eurjchem-11 88 157     SPACE eurjchem-11 88 158 c23h28cl2n3o3 c23h28cl2n3o3 NOUN eurjchem-11 88 159     SPACE eurjchem-11 88 160 464.1429 464.1429 NUM eurjchem-11 88 161 464.1427 464.1427 NUM eurjchem-11 88 162 0.0002 0.0002 NUM eurjchem-11 88 163     SPACE eurjchem-11 88 164 0.4 0.4 NUM eurjchem-11 88 165 unknown unknown ADJ eurjchem-11 88 166     SPACE eurjchem-11 88 167 imp‐3 imp‐3 PROPN eurjchem-11 88 168     SPACE eurjchem-11 88 169 1.14 1.14 NUM eurjchem-11 88 170     SPACE eurjchem-11 88 171 c13h16no2 c13h16no2 NOUN eurjchem-11 88 172     SPACE eurjchem-11 88 173 218.1181 218.1181 NUM eurjchem-11 88 174 218.1182 218.1182 NUM eurjchem-11 88 175 0.0001 0.0001 NUM eurjchem-11 88 176     SPACE eurjchem-11 88 177 0.4 0.4 NUM eurjchem-11 88 178     SPACE eurjchem-11 88 179 table table NOUN eurjchem-11 88 180     SPACE eurjchem-11 88 181 3 3 NUM eurjchem-11 88 182 . . PUNCT eurjchem-11 88 183       SPACE eurjchem-11 88 184 rts rt NOUN eurjchem-11 88 185 , , PUNCT eurjchem-11 88 186     SPACE eurjchem-11 88 187 rrts rrt NOUN eurjchem-11 88 188     SPACE eurjchem-11 88 189 and and CCONJ eurjchem-11 88 190     SPACE eurjchem-11 88 191 masses masse NOUN eurjchem-11 88 192     SPACE eurjchem-11 88 193 for for ADP eurjchem-11 88 194     SPACE eurjchem-11 88 195 molecular molecular ADJ eurjchem-11 88 196     SPACE eurjchem-11 88 197 ion ion NOUN eurjchem-11 88 198     SPACE eurjchem-11 88 199 peaks peak NOUN eurjchem-11 88 200     SPACE eurjchem-11 88 201 of of ADP eurjchem-11 88 202     SPACE eurjchem-11 88 203 known know VERB eurjchem-11 88 204     SPACE eurjchem-11 88 205 and and CCONJ eurjchem-11 88 206     SPACE eurjchem-11 88 207 unknown unknown ADJ eurjchem-11 88 208     SPACE eurjchem-11 88 209 impurities impurity NOUN eurjchem-11 88 210     SPACE eurjchem-11 88 211 and and CCONJ eurjchem-11 88 212     SPACE eurjchem-11 88 213 their their PRON eurjchem-11 88 214     SPACE eurjchem-11 88 215 major major ADJ eurjchem-11 88 216     SPACE eurjchem-11 88 217 fragments fragment NOUN eurjchem-11 88 218 . . PUNCT eurjchem-11 88 219     SPACE eurjchem-11 88 220 compound compound NOUN eurjchem-11 88 221     SPACE eurjchem-11 88 222 rt(min rt(min PROPN eurjchem-11 88 223 ) ) PUNCT eurjchem-11 88 224     SPACE eurjchem-11 88 225 rrt rrt NOUN eurjchem-11 88 226     SPACE eurjchem-11 88 227 molecular molecular ADJ eurjchem-11 88 228     SPACE eurjchem-11 88 229 ions ion NOUN eurjchem-11 88 230     SPACE eurjchem-11 88 231 ms ms PROPN eurjchem-11 88 232 / / SYM eurjchem-11 88 233 ms ms NOUN eurjchem-11 88 234     SPACE eurjchem-11 88 235 fragments fragment NOUN eurjchem-11 88 236     SPACE eurjchem-11 88 237 aripiprazolea aripiprazolea ADV eurjchem-11 88 238     SPACE eurjchem-11 88 239 31.24 31.24 NUM eurjchem-11 88 240     SPACE eurjchem-11 88 241 1.00 1.00 NUM eurjchem-11 88 242 448 448 NUM eurjchem-11 88 243     SPACE eurjchem-11 89 1 [ [ X eurjchem-11 89 2 m+h]+ m+h]+ NOUN eurjchem-11 89 3 285 285 NUM eurjchem-11 89 4 , , PUNCT eurjchem-11 89 5     SPACE eurjchem-11 89 6 218 218 NUM eurjchem-11 89 7 , , PUNCT eurjchem-11 89 8     SPACE eurjchem-11 89 9 176 176 NOUN eurjchem-11 89 10     SPACE eurjchem-11 89 11 7‐hdqa 7‐hdqa PRON eurjchem-11 89 12     SPACE eurjchem-11 89 13 15.34 15.34 NUM eurjchem-11 89 14     SPACE eurjchem-11 89 15 0.21 0.21 NUM eurjchem-11 89 16 164 164 NUM eurjchem-11 89 17     SPACE eurjchem-11 90 1 [ [ X eurjchem-11 90 2 m+h]+ m+h]+ PROPN eurjchem-11 90 3 146 146 NUM eurjchem-11 90 4     SPACE eurjchem-11 90 5 , , PUNCT eurjchem-11 90 6     SPACE eurjchem-11 90 7 122 122 NUM eurjchem-11 90 8 , , PUNCT eurjchem-11 90 9     SPACE eurjchem-11 90 10 110 110 NUM eurjchem-11 90 11     SPACE eurjchem-11 90 12 dcppa dcppa PROPN eurjchem-11 90 13     SPACE eurjchem-11 90 14 6.729 6.729 NUM eurjchem-11 90 15     SPACE eurjchem-11 90 16 0.49 0.49 NUM eurjchem-11 90 17 231 231 NUM eurjchem-11 90 18     SPACE eurjchem-11 91 1 [ [ X eurjchem-11 91 2 m+h]+ m+h]+ NOUN eurjchem-11 91 3 188 188 NUM eurjchem-11 91 4 , , PUNCT eurjchem-11 91 5     SPACE eurjchem-11 91 6 153 153 NUM eurjchem-11 91 7     SPACE eurjchem-11 91 8 imp‐ba imp‐ba PROPN eurjchem-11 91 9     SPACE eurjchem-11 91 10 42.20 42.20 NUM eurjchem-11 91 11     SPACE eurjchem-11 91 12 1.35 1.35 NUM eurjchem-11 91 13 403 403 NUM eurjchem-11 91 14     SPACE eurjchem-11 92 1 [ [ X eurjchem-11 92 2 m+na]+ m+na]+ NOUN eurjchem-11 92 3 218 218 NUM eurjchem-11 92 4 , , PUNCT eurjchem-11 92 5     SPACE eurjchem-11 92 6 176 176 NUM eurjchem-11 92 7 , , PUNCT eurjchem-11 92 8     SPACE eurjchem-11 92 9 164 164 NUM eurjchem-11 92 10     SPACE eurjchem-11 92 11 apr‐ia apr‐ia PROPN eurjchem-11 92 12     SPACE eurjchem-11 92 13 43.61 43.61 NUM eurjchem-11 92 14     SPACE eurjchem-11 92 15 1.39 1.39 NUM eurjchem-11 92 16 298 298 NUM eurjchem-11 92 17     SPACE eurjchem-11 93 1 [ [ X eurjchem-11 93 2 m+h]+ m+h]+ NOUN eurjchem-11 93 3 218 218 NUM eurjchem-11 93 4 , , PUNCT eurjchem-11 93 5     SPACE eurjchem-11 93 6 176 176 NUM eurjchem-11 93 7 , , PUNCT eurjchem-11 93 8     SPACE eurjchem-11 93 9 164 164 NUM eurjchem-11 93 10     SPACE eurjchem-11 93 11 n‐bdqa n‐bdqa PUNCT eurjchem-11 93 12     SPACE eurjchem-11 93 13 45.08 45.08 NUM eurjchem-11 93 14     SPACE eurjchem-11 93 15 1.44 1.44 NUM eurjchem-11 93 16 665 665 NUM eurjchem-11 93 17     SPACE eurjchem-11 94 1 [ [ X eurjchem-11 94 2 m+h]+ m+h]+ PROPN eurjchem-11 94 3 285 285 NUM eurjchem-11 94 4     SPACE eurjchem-11 94 5 unknown unknown NOUN eurjchem-11 94 6     SPACE eurjchem-11 94 7 imp‐1b imp‐1b VERB eurjchem-11 94 8     SPACE eurjchem-11 94 9 13.854 13.854 NUM eurjchem-11 94 10     SPACE eurjchem-11 94 11 0.45 0.45 NUM eurjchem-11 94 12 285 285 NUM eurjchem-11 94 13     SPACE eurjchem-11 95 1 [ [ X eurjchem-11 95 2 m+h]+ m+h]+ NOUN eurjchem-11 95 3 231 231 NUM eurjchem-11 95 4 , , PUNCT eurjchem-11 95 5     SPACE eurjchem-11 95 6 188 188 NUM eurjchem-11 95 7 , , PUNCT eurjchem-11 95 8     SPACE eurjchem-11 95 9 154 154 NUM eurjchem-11 95 10     SPACE eurjchem-11 95 11 unknown unknown ADJ eurjchem-11 95 12     SPACE eurjchem-11 95 13 imp‐2b imp‐2b NOUN eurjchem-11 95 14     SPACE eurjchem-11 95 15 32.572 32.572 NUM eurjchem-11 95 16     SPACE eurjchem-11 95 17 1.06 1.06 NUM eurjchem-11 95 18 464 464 NUM eurjchem-11 95 19     SPACE eurjchem-11 96 1 [ [ X eurjchem-11 96 2 m+h]+ m+h]+ NOUN eurjchem-11 96 3 285 285 NUM eurjchem-11 96 4 , , PUNCT eurjchem-11 96 5     SPACE eurjchem-11 96 6 218 218 NUM eurjchem-11 96 7 , , PUNCT eurjchem-11 96 8     SPACE eurjchem-11 96 9 176 176 NUM eurjchem-11 96 10 , , PUNCT eurjchem-11 96 11     SPACE eurjchem-11 96 12 164 164 NUM eurjchem-11 96 13     SPACE eurjchem-11 96 14 unknown unknown ADJ eurjchem-11 96 15     SPACE eurjchem-11 96 16 imp‐3b imp‐3b PROPN eurjchem-11 96 17     SPACE eurjchem-11 96 18 35.028 35.028 NUM eurjchem-11 96 19     SPACE eurjchem-11 96 20 1.14 1.14 NUM eurjchem-11 96 21 218 218 NUM eurjchem-11 96 22     SPACE eurjchem-11 97 1 [ [ X eurjchem-11 97 2 m+h]+ m+h]+ PROPN eurjchem-11 97 3 176 176 NUM eurjchem-11 97 4 , , PUNCT eurjchem-11 97 5     SPACE eurjchem-11 97 6 164 164 NUM eurjchem-11 97 7     SPACE eurjchem-11 97 8 , , PUNCT eurjchem-11 97 9     SPACE eurjchem-11 97 10 146 146 NUM eurjchem-11 97 11     SPACE eurjchem-11 97 12 a a DET eurjchem-11 97 13       SPACE eurjchem-11 97 14 known know VERB eurjchem-11 97 15     SPACE eurjchem-11 97 16 impurities impurity NOUN eurjchem-11 97 17     SPACE eurjchem-11 97 18 at at ADP eurjchem-11 97 19     SPACE eurjchem-11 97 20 1.0 1.0 NUM eurjchem-11 97 21 % % NOUN eurjchem-11 97 22       SPACE eurjchem-11 97 23 level level NOUN eurjchem-11 97 24     SPACE eurjchem-11 97 25 spiked spike VERB eurjchem-11 97 26     SPACE eurjchem-11 97 27 solution solution NOUN eurjchem-11 97 28 . . PUNCT eurjchem-11 97 29     SPACE eurjchem-11 98 1 b b X eurjchem-11 98 2     SPACE eurjchem-11 98 3 unknown unknown ADJ eurjchem-11 98 4     SPACE eurjchem-11 98 5 impurities impurity NOUN eurjchem-11 98 6     SPACE eurjchem-11 98 7 under under ADP eurjchem-11 98 8     SPACE eurjchem-11 98 9 thermal thermal ADJ eurjchem-11 98 10     SPACE eurjchem-11 98 11 degradation degradation NOUN eurjchem-11 98 12 . . PUNCT eurjchem-11 98 13         SPACE eurjchem-11 98 14 which which PRON eurjchem-11 98 15     SPACE eurjchem-11 98 16 constitutes constitute VERB eurjchem-11 98 17     SPACE eurjchem-11 98 18 a a DET eurjchem-11 98 19     SPACE eurjchem-11 98 20 higher high ADJ eurjchem-11 98 21     SPACE eurjchem-11 98 22 order order NOUN eurjchem-11 98 23     SPACE eurjchem-11 98 24 mass mass ADJ eurjchem-11 98 25     SPACE eurjchem-11 98 26 identification identification NOUN eurjchem-11 98 27     SPACE eurjchem-11 98 28 than than ADP eurjchem-11 98 29     SPACE eurjchem-11 98 30 those those PRON eurjchem-11 98 31     SPACE eurjchem-11 98 32 afforded afford VERB eurjchem-11 98 33     SPACE eurjchem-11 98 34 by by ADP eurjchem-11 98 35     SPACE eurjchem-11 98 36 nominal nominal ADJ eurjchem-11 98 37     SPACE eurjchem-11 98 38 mass mass ADJ eurjchem-11 98 39     SPACE eurjchem-11 98 40 measurements measurement NOUN eurjchem-11 98 41     SPACE eurjchem-11 98 42 obtained obtain VERB eurjchem-11 98 43     SPACE eurjchem-11 98 44 by by ADP eurjchem-11 98 45     SPACE eurjchem-11 98 46 other other ADJ eurjchem-11 98 47     SPACE eurjchem-11 98 48 types type NOUN eurjchem-11 98 49     SPACE eurjchem-11 98 50 of of ADP eurjchem-11 98 51     SPACE eurjchem-11 98 52 mass mass ADJ eurjchem-11 98 53     SPACE eurjchem-11 98 54 analyzers analyzer NOUN eurjchem-11 98 55     SPACE eurjchem-11 99 1 [ [ X eurjchem-11 99 2 20 20 NUM eurjchem-11 99 3 ] ] PUNCT eurjchem-11 99 4 . . PUNCT eurjchem-11 99 5     SPACE eurjchem-11 99 6 in in ADP eurjchem-11 99 7     SPACE eurjchem-11 99 8 qtof qtof NOUN eurjchem-11 99 9 , , PUNCT eurjchem-11 99 10     SPACE eurjchem-11 99 11 the the DET eurjchem-11 99 12     SPACE eurjchem-11 99 13 selectivity selectivity NOUN eurjchem-11 99 14     SPACE eurjchem-11 99 15 of of ADP eurjchem-11 99 16     SPACE eurjchem-11 99 17 precursor precursor NOUN eurjchem-11 99 18     SPACE eurjchem-11 99 19 ion ion NOUN eurjchem-11 99 20     SPACE eurjchem-11 99 21 scans scan NOUN eurjchem-11 99 22     SPACE eurjchem-11 99 23 is be AUX eurjchem-11 99 24     SPACE eurjchem-11 99 25 very very ADV eurjchem-11 99 26     SPACE eurjchem-11 99 27 high high ADJ eurjchem-11 99 28     SPACE eurjchem-11 99 29 because because SCONJ eurjchem-11 99 30     SPACE eurjchem-11 99 31 the the DET eurjchem-11 99 32     SPACE eurjchem-11 99 33 high high ADJ eurjchem-11 99 34     SPACE eurjchem-11 99 35 resolving resolving NOUN eurjchem-11 99 36     SPACE eurjchem-11 99 37 power power NOUN eurjchem-11 99 38     SPACE eurjchem-11 99 39 of of ADP eurjchem-11 99 40     SPACE eurjchem-11 99 41 the the DET eurjchem-11 99 42     SPACE eurjchem-11 99 43 reflectron reflectron NOUN eurjchem-11 99 44 – – PUNCT eurjchem-11 99 45 tof tof NOUN eurjchem-11 99 46     SPACE eurjchem-11 99 47 mass mass ADJ eurjchem-11 99 48     SPACE eurjchem-11 99 49 analyzers analyzer NOUN eurjchem-11 99 50     SPACE eurjchem-11 99 51 provides provide VERB eurjchem-11 99 52     SPACE eurjchem-11 99 53 high high ADJ eurjchem-11 99 54     SPACE eurjchem-11 99 55 accuracy accuracy NOUN eurjchem-11 99 56     SPACE eurjchem-11 99 57 fragment fragment NOUN eurjchem-11 99 58     SPACE eurjchem-11 99 59 ions ion NOUN eurjchem-11 99 60     SPACE eurjchem-11 99 61 without without ADP eurjchem-11 99 62     SPACE eurjchem-11 99 63 compromising compromise VERB eurjchem-11 99 64     SPACE eurjchem-11 99 65 sensitivity sensitivity NOUN eurjchem-11 99 66     SPACE eurjchem-11 100 1 [ [ X eurjchem-11 100 2 21 21 NUM eurjchem-11 100 3 ] ] PUNCT eurjchem-11 100 4 . . PUNCT eurjchem-11 100 5     SPACE eurjchem-11 100 6 the the DET eurjchem-11 100 7     SPACE eurjchem-11 100 8 elemental elemental NOUN eurjchem-11 100 9     SPACE eurjchem-11 100 10 composition composition NOUN eurjchem-11 100 11     SPACE eurjchem-11 100 12 was be AUX eurjchem-11 100 13     SPACE eurjchem-11 100 14 a a DET eurjchem-11 100 15     SPACE eurjchem-11 100 16 complement complement NOUN eurjchem-11 100 17     SPACE eurjchem-11 100 18 from from ADP eurjchem-11 100 19     SPACE eurjchem-11 100 20 the the DET eurjchem-11 100 21     SPACE eurjchem-11 100 22 interpreted interpret VERB eurjchem-11 100 23     SPACE eurjchem-11 100 24 fragmentation fragmentation NOUN eurjchem-11 100 25     SPACE eurjchem-11 100 26 pattern pattern NOUN eurjchem-11 100 27     SPACE eurjchem-11 100 28 and and CCONJ eurjchem-11 100 29     SPACE eurjchem-11 100 30 the the DET eurjchem-11 100 31     SPACE eurjchem-11 100 32 accurate accurate ADJ eurjchem-11 100 33     SPACE eurjchem-11 100 34 mass mass PROPN eurjchem-11 100 35     SPACE eurjchem-11 100 36 measurement measurement NOUN eurjchem-11 100 37     SPACE eurjchem-11 100 38 of of ADP eurjchem-11 100 39     SPACE eurjchem-11 100 40 the the DET eurjchem-11 100 41     SPACE eurjchem-11 100 42 obtained obtain VERB eurjchem-11 100 43     SPACE eurjchem-11 100 44 product product NOUN eurjchem-11 100 45     SPACE eurjchem-11 100 46 ions ion NOUN eurjchem-11 100 47 , , PUNCT eurjchem-11 100 48     SPACE eurjchem-11 100 49 thus thus ADV eurjchem-11 100 50     SPACE eurjchem-11 100 51 relieving relieve VERB eurjchem-11 100 52     SPACE eurjchem-11 100 53 existing exist VERB eurjchem-11 100 54     SPACE eurjchem-11 100 55 equivocalnesses equivocalness NOUN eurjchem-11 100 56 . . PUNCT eurjchem-11 100 57       SPACE eurjchem-11 100 58 mass mass PROPN eurjchem-11 100 59     SPACE eurjchem-11 100 60 measurement measurement NOUN eurjchem-11 100 61     SPACE eurjchem-11 100 62 accuracy accuracy NOUN eurjchem-11 100 63     SPACE eurjchem-11 100 64 along along ADP eurjchem-11 100 65     SPACE eurjchem-11 100 66 with with ADP eurjchem-11 100 67     SPACE eurjchem-11 100 68 characteristic characteristic ADJ eurjchem-11 100 69     SPACE eurjchem-11 100 70 retention retention NOUN eurjchem-11 100 71     SPACE eurjchem-11 100 72 time time NOUN eurjchem-11 100 73 , , PUNCT eurjchem-11 100 74     SPACE eurjchem-11 100 75 usually usually ADV eurjchem-11 100 76     SPACE eurjchem-11 100 77 provides provide VERB eurjchem-11 100 78     SPACE eurjchem-11 100 79 highly highly ADV eurjchem-11 100 80     SPACE eurjchem-11 100 81 reliable reliable ADJ eurjchem-11 100 82     SPACE eurjchem-11 100 83 identification identification NOUN eurjchem-11 100 84     SPACE eurjchem-11 100 85 of of ADP eurjchem-11 100 86     SPACE eurjchem-11 100 87 target target NOUN eurjchem-11 100 88     SPACE eurjchem-11 100 89 species specie NOUN eurjchem-11 100 90     SPACE eurjchem-11 101 1 [ [ X eurjchem-11 101 2 22 22 NUM eurjchem-11 101 3 ] ] PUNCT eurjchem-11 101 4 . . PUNCT eurjchem-11 101 5     SPACE eurjchem-11 101 6 table table NOUN eurjchem-11 101 7     SPACE eurjchem-11 101 8 2 2 NUM eurjchem-11 101 9     SPACE eurjchem-11 101 10 lists list NOUN eurjchem-11 101 11     SPACE eurjchem-11 101 12 the the DET eurjchem-11 101 13     SPACE eurjchem-11 101 14 mass mass ADJ eurjchem-11 101 15     SPACE eurjchem-11 101 16 accuracies accuracy NOUN eurjchem-11 101 17     SPACE eurjchem-11 101 18 obtained obtain VERB eurjchem-11 101 19     SPACE eurjchem-11 101 20 in in ADP eurjchem-11 101 21     SPACE eurjchem-11 101 22 the the DET eurjchem-11 101 23     SPACE eurjchem-11 101 24 mass mass PROPN eurjchem-11 101 25     SPACE eurjchem-11 101 26 measurement measurement NOUN eurjchem-11 101 27     SPACE eurjchem-11 101 28 of of ADP eurjchem-11 101 29     SPACE eurjchem-11 101 30 the the DET eurjchem-11 101 31     SPACE eurjchem-11 101 32 protonated protonate VERB eurjchem-11 101 33     SPACE eurjchem-11 101 34 molecule molecule NOUN eurjchem-11 101 35     SPACE eurjchem-11 101 36 of of ADP eurjchem-11 101 37     SPACE eurjchem-11 101 38 aripiprazole aripiprazole NOUN eurjchem-11 101 39     SPACE eurjchem-11 101 40 and and CCONJ eurjchem-11 101 41     SPACE eurjchem-11 101 42 its its PRON eurjchem-11 101 43     SPACE eurjchem-11 101 44 unknown unknown ADJ eurjchem-11 101 45     SPACE eurjchem-11 101 46 impurities impurity NOUN eurjchem-11 101 47 . . PUNCT eurjchem-11 101 48     SPACE eurjchem-11 101 49 the the DET eurjchem-11 101 50     SPACE eurjchem-11 101 51 mass mass ADJ eurjchem-11 101 52     SPACE eurjchem-11 101 53 error error NOUN eurjchem-11 101 54     SPACE eurjchem-11 101 55 obtained obtain VERB eurjchem-11 101 56     SPACE eurjchem-11 101 57 for for ADP eurjchem-11 101 58     SPACE eurjchem-11 101 59 all all DET eurjchem-11 101 60     SPACE eurjchem-11 101 61 unknown unknown ADJ eurjchem-11 101 62     SPACE eurjchem-11 101 63 impurities impurity NOUN eurjchem-11 101 64     SPACE eurjchem-11 101 65 including include VERB eurjchem-11 101 66     SPACE eurjchem-11 101 67 aripiprazole aripiprazole NOUN eurjchem-11 101 68     SPACE eurjchem-11 101 69 ( ( PUNCT eurjchem-11 101 70 precursor precursor NOUN eurjchem-11 101 71     SPACE eurjchem-11 101 72 ions ion NOUN eurjchem-11 101 73 ) ) PUNCT eurjchem-11 101 74     SPACE eurjchem-11 101 75 was be AUX eurjchem-11 101 76     SPACE eurjchem-11 101 77 in in ADP eurjchem-11 101 78     SPACE eurjchem-11 101 79 the the DET eurjchem-11 101 80     SPACE eurjchem-11 101 81 range range NOUN eurjchem-11 101 82     SPACE eurjchem-11 101 83 of of ADP eurjchem-11 101 84     SPACE eurjchem-11 101 85 0.4–1.4 0.4–1.4 NOUN eurjchem-11 101 86     SPACE eurjchem-11 101 87 ppm ppm NOUN eurjchem-11 101 88 . . PUNCT eurjchem-11 101 89     SPACE eurjchem-11 102 1 this this PRON eurjchem-11 102 2     SPACE eurjchem-11 102 3 was be AUX eurjchem-11 102 4     SPACE eurjchem-11 102 5 less less ADJ eurjchem-11 102 6     SPACE eurjchem-11 102 7 than than ADP eurjchem-11 102 8     SPACE eurjchem-11 102 9 the the DET eurjchem-11 102 10     SPACE eurjchem-11 102 11 widely widely ADV eurjchem-11 102 12     SPACE eurjchem-11 102 13 accepted accept VERB eurjchem-11 102 14     SPACE eurjchem-11 102 15 accuracy accuracy NOUN eurjchem-11 102 16     SPACE eurjchem-11 102 17 threshold threshold NOUN eurjchem-11 102 18     SPACE eurjchem-11 102 19 of of ADP eurjchem-11 102 20     SPACE eurjchem-11 102 21 5 5 NUM eurjchem-11 102 22     SPACE eurjchem-11 102 23 ppm ppm NOUN eurjchem-11 102 24     SPACE eurjchem-11 102 25 [ [ X eurjchem-11 102 26 23 23 NUM eurjchem-11 102 27 ] ] PUNCT eurjchem-11 102 28 . . PUNCT eurjchem-11 102 29     SPACE eurjchem-11 102 30 in in ADP eurjchem-11 102 31     SPACE eurjchem-11 102 32 accordance accordance NOUN eurjchem-11 102 33     SPACE eurjchem-11 102 34 with with ADP eurjchem-11 102 35     SPACE eurjchem-11 102 36 experimental experimental ADJ eurjchem-11 102 37     SPACE eurjchem-11 102 38 data datum NOUN eurjchem-11 102 39 , , PUNCT eurjchem-11 102 40     SPACE eurjchem-11 102 41 the the DET eurjchem-11 102 42     SPACE eurjchem-11 102 43 best good ADJ eurjchem-11 102 44     SPACE eurjchem-11 102 45 mass mass ADJ eurjchem-11 102 46     SPACE eurjchem-11 102 47 accuracy accuracy NOUN eurjchem-11 102 48     SPACE eurjchem-11 102 49 was be AUX eurjchem-11 102 50     SPACE eurjchem-11 102 51 obtained obtain VERB eurjchem-11 102 52 . . PUNCT eurjchem-11 102 53     SPACE eurjchem-11 102 54 the the DET eurjchem-11 102 55     SPACE eurjchem-11 102 56 accurate accurate ADJ eurjchem-11 102 57     SPACE eurjchem-11 102 58 mass mass ADJ eurjchem-11 102 59     SPACE eurjchem-11 102 60 measurements measurement NOUN eurjchem-11 102 61     SPACE eurjchem-11 102 62 of of ADP eurjchem-11 102 63     SPACE eurjchem-11 102 64 aripiprazole aripiprazole NOUN eurjchem-11 102 65     SPACE eurjchem-11 102 66 and and CCONJ eurjchem-11 102 67     SPACE eurjchem-11 102 68 its its PRON eurjchem-11 102 69     SPACE eurjchem-11 102 70 unknown unknown ADJ eurjchem-11 102 71     SPACE eurjchem-11 102 72 impurities impurity NOUN eurjchem-11 102 73     SPACE eurjchem-11 102 74 were be AUX eurjchem-11 102 75     SPACE eurjchem-11 102 76 obtained obtain VERB eurjchem-11 102 77     SPACE eurjchem-11 102 78 from from ADP eurjchem-11 102 79     SPACE eurjchem-11 102 80 thermal thermal ADJ eurjchem-11 102 81     SPACE eurjchem-11 102 82 degradation degradation NOUN eurjchem-11 102 83     SPACE eurjchem-11 102 84 sample sample NOUN eurjchem-11 102 85     SPACE eurjchem-11 102 86 using use VERB eurjchem-11 102 87     SPACE eurjchem-11 102 88 the the DET eurjchem-11 102 89     SPACE eurjchem-11 102 90 qtof‐ms qtof‐ms NOUN eurjchem-11 102 91 / / SYM eurjchem-11 102 92 ms ms NOUN eurjchem-11 102 93     SPACE eurjchem-11 102 94 at at ADP eurjchem-11 102 95     SPACE eurjchem-11 102 96 the the DET eurjchem-11 102 97     SPACE eurjchem-11 102 98 optimized optimized ADJ eurjchem-11 102 99     SPACE eurjchem-11 102 100 collision collision NOUN eurjchem-11 102 101     SPACE eurjchem-11 102 102 energy energy NOUN eurjchem-11 102 103 . . PUNCT eurjchem-11 102 104         SPACE eurjchem-11 103 1 3.9 3.9 NUM eurjchem-11 103 2 . . PUNCT eurjchem-11 103 3     SPACE eurjchem-11 103 4 identification identification NOUN eurjchem-11 103 5     SPACE eurjchem-11 103 6 of of ADP eurjchem-11 103 7     SPACE eurjchem-11 103 8 the the DET eurjchem-11 103 9     SPACE eurjchem-11 103 10 known know VERB eurjchem-11 103 11     SPACE eurjchem-11 103 12 and and CCONJ eurjchem-11 103 13     SPACE eurjchem-11 103 14 unknown unknown ADJ eurjchem-11 103 15     SPACE eurjchem-11 103 16 impurities impurity NOUN eurjchem-11 103 17     SPACE eurjchem-11 103 18 by by ADP eurjchem-11 103 19     SPACE eurjchem-11 103 20 qtof­ms qtof­ms NOUN eurjchem-11 103 21           SPACE eurjchem-11 103 22 to to PART eurjchem-11 103 23     SPACE eurjchem-11 103 24 confirm confirm VERB eurjchem-11 103 25     SPACE eurjchem-11 103 26 the the DET eurjchem-11 103 27     SPACE eurjchem-11 103 28 known know VERB eurjchem-11 103 29     SPACE eurjchem-11 103 30 impurities impurity NOUN eurjchem-11 103 31     SPACE eurjchem-11 103 32 retention retention NOUN eurjchem-11 103 33     SPACE eurjchem-11 103 34 times time NOUN eurjchem-11 103 35     SPACE eurjchem-11 103 36 ( ( PUNCT eurjchem-11 103 37 rt rt PROPN eurjchem-11 103 38 ) ) PUNCT eurjchem-11 103 39 , , PUNCT eurjchem-11 103 40     SPACE eurjchem-11 103 41 rrts rrt NOUN eurjchem-11 103 42     SPACE eurjchem-11 103 43 and and CCONJ eurjchem-11 103 44     SPACE eurjchem-11 103 45 their their PRON eurjchem-11 103 46     SPACE eurjchem-11 103 47 molecular molecular ADJ eurjchem-11 103 48     SPACE eurjchem-11 103 49 ion ion NOUN eurjchem-11 103 50     SPACE eurjchem-11 103 51 peaks peak NOUN eurjchem-11 103 52 , , PUNCT eurjchem-11 103 53     SPACE eurjchem-11 103 54 each each PRON eurjchem-11 103 55     SPACE eurjchem-11 103 56 and and CCONJ eurjchem-11 103 57     SPACE eurjchem-11 103 58 every every DET eurjchem-11 103 59     SPACE eurjchem-11 103 60 known know VERB eurjchem-11 103 61     SPACE eurjchem-11 103 62 impurity impurity NOUN eurjchem-11 103 63     SPACE eurjchem-11 103 64 was be AUX eurjchem-11 103 65     SPACE eurjchem-11 103 66 spiked spike VERB eurjchem-11 103 67     SPACE eurjchem-11 103 68 at at ADP eurjchem-11 103 69     SPACE eurjchem-11 103 70 1.0 1.0 NUM eurjchem-11 103 71     SPACE eurjchem-11 103 72 % % NOUN eurjchem-11 103 73     SPACE eurjchem-11 103 74 level level NOUN eurjchem-11 103 75     SPACE eurjchem-11 103 76 to to ADP eurjchem-11 103 77     SPACE eurjchem-11 103 78 the the DET eurjchem-11 103 79     SPACE eurjchem-11 103 80 aripiprazole aripiprazole NOUN eurjchem-11 103 81     SPACE eurjchem-11 103 82 drug drug NOUN eurjchem-11 103 83     SPACE eurjchem-11 103 84 product product NOUN eurjchem-11 103 85     SPACE eurjchem-11 103 86 and and CCONJ eurjchem-11 103 87     SPACE eurjchem-11 103 88 the the DET eurjchem-11 103 89     SPACE eurjchem-11 103 90 analysis analysis NOUN eurjchem-11 103 91     SPACE eurjchem-11 103 92 was be AUX eurjchem-11 103 93     SPACE eurjchem-11 103 94 carried carry VERB eurjchem-11 103 95     SPACE eurjchem-11 103 96 out out ADP eurjchem-11 103 97 . . PUNCT eurjchem-11 103 98     SPACE eurjchem-11 103 99 figure figure NOUN eurjchem-11 103 100     SPACE eurjchem-11 103 101 2b 2b NOUN eurjchem-11 103 102     SPACE eurjchem-11 103 103 presents present VERB eurjchem-11 103 104     SPACE eurjchem-11 103 105 the the DET eurjchem-11 103 106     SPACE eurjchem-11 103 107 chromatogram chromatogram NOUN eurjchem-11 103 108     SPACE eurjchem-11 103 109 showing show VERB eurjchem-11 103 110     SPACE eurjchem-11 103 111 the the DET eurjchem-11 103 112     SPACE eurjchem-11 103 113 separation separation NOUN eurjchem-11 103 114     SPACE eurjchem-11 103 115 of of ADP eurjchem-11 103 116     SPACE eurjchem-11 103 117 aripiprazole aripiprazole NOUN eurjchem-11 103 118     SPACE eurjchem-11 103 119 from from ADP eurjchem-11 103 120     SPACE eurjchem-11 103 121 its its PRON eurjchem-11 103 122     SPACE eurjchem-11 103 123 known know VERB eurjchem-11 103 124     SPACE eurjchem-11 103 125 impurities impurity NOUN eurjchem-11 103 126     SPACE eurjchem-11 103 127 and and CCONJ eurjchem-11 103 128     SPACE eurjchem-11 103 129 the the DET eurjchem-11 103 130     SPACE eurjchem-11 103 131 respective respective ADJ eurjchem-11 103 132     SPACE eurjchem-11 103 133 data datum NOUN eurjchem-11 103 134     SPACE eurjchem-11 103 135 including include VERB eurjchem-11 103 136     SPACE eurjchem-11 103 137 ms ms PROPN eurjchem-11 103 138     SPACE eurjchem-11 103 139 were be AUX eurjchem-11 103 140     SPACE eurjchem-11 103 141 presented present VERB eurjchem-11 103 142     SPACE eurjchem-11 103 143 in in ADP eurjchem-11 103 144     SPACE eurjchem-11 103 145 table table NOUN eurjchem-11 103 146     SPACE eurjchem-11 103 147 3 3 NUM eurjchem-11 103 148 . . PUNCT eurjchem-11 103 149     SPACE eurjchem-11 103 150 the the DET eurjchem-11 103 151     SPACE eurjchem-11 103 152 collision collision NOUN eurjchem-11 103 153     SPACE eurjchem-11 103 154 induced induce VERB eurjchem-11 103 155     SPACE eurjchem-11 103 156 dissociation dissociation NOUN eurjchem-11 103 157     SPACE eurjchem-11 103 158 energy energy NOUN eurjchem-11 103 159     SPACE eurjchem-11 103 160 was be AUX eurjchem-11 103 161     SPACE eurjchem-11 103 162 optimized optimize VERB eurjchem-11 103 163     SPACE eurjchem-11 103 164 for for ADP eurjchem-11 103 165     SPACE eurjchem-11 103 166 every every DET eurjchem-11 103 167     SPACE eurjchem-11 103 168 known know VERB eurjchem-11 103 169     SPACE eurjchem-11 103 170 impurity impurity NOUN eurjchem-11 103 171     SPACE eurjchem-11 103 172 in in ADP eurjchem-11 103 173     SPACE eurjchem-11 103 174 qtof qtof PROPN eurjchem-11 103 175     SPACE eurjchem-11 103 176 mass mass PROPN eurjchem-11 103 177     SPACE eurjchem-11 103 178 spectrometer spectrometer NOUN eurjchem-11 103 179     SPACE eurjchem-11 103 180 to to PART eurjchem-11 103 181     SPACE eurjchem-11 103 182 get get VERB eurjchem-11 103 183     SPACE eurjchem-11 103 184 the the DET eurjchem-11 103 185     SPACE eurjchem-11 103 186 major major ADJ eurjchem-11 103 187     SPACE eurjchem-11 103 188 fragments fragment NOUN eurjchem-11 103 189 . . PUNCT eurjchem-11 103 190     SPACE eurjchem-11 104 1 the the DET eurjchem-11 104 2     SPACE eurjchem-11 104 3 m m PROPN eurjchem-11 104 4 / / SYM eurjchem-11 104 5 z z NOUN eurjchem-11 104 6     SPACE eurjchem-11 104 7 values value NOUN eurjchem-11 104 8     SPACE eurjchem-11 104 9 corresponding correspond VERB eurjchem-11 104 10     SPACE eurjchem-11 104 11 to to ADP eurjchem-11 104 12     SPACE eurjchem-11 104 13 molecular molecular ADJ eurjchem-11 104 14     SPACE eurjchem-11 104 15 ion ion NOUN eurjchem-11 104 16     SPACE eurjchem-11 104 17 peaks peak NOUN eurjchem-11 104 18     SPACE eurjchem-11 104 19 and and CCONJ eurjchem-11 104 20     SPACE eurjchem-11 104 21 their their PRON eurjchem-11 104 22     SPACE eurjchem-11 104 23 ms ms PROPN eurjchem-11 104 24 / / SYM eurjchem-11 104 25 ms ms NOUN eurjchem-11 104 26     SPACE eurjchem-11 104 27 fragments fragment NOUN eurjchem-11 104 28     SPACE eurjchem-11 104 29 contributed contribute VERB eurjchem-11 104 30     SPACE eurjchem-11 104 31 in in ADP eurjchem-11 104 32     SPACE eurjchem-11 104 33 the the DET eurjchem-11 104 34     SPACE eurjchem-11 104 35 confirmation confirmation NOUN eurjchem-11 104 36     SPACE eurjchem-11 104 37 of of ADP eurjchem-11 104 38     SPACE eurjchem-11 104 39 the the DET eurjchem-11 104 40     SPACE eurjchem-11 104 41 known know VERB eurjchem-11 104 42     SPACE eurjchem-11 104 43 impurities impurity NOUN eurjchem-11 104 44 . . PUNCT eurjchem-11 104 45     SPACE eurjchem-11 105 1 figure figure NOUN eurjchem-11 105 2     SPACE eurjchem-11 105 3 3a 3a NUM eurjchem-11 105 4     SPACE eurjchem-11 105 5 shows show VERB eurjchem-11 105 6     SPACE eurjchem-11 105 7 the the DET eurjchem-11 105 8     SPACE eurjchem-11 105 9 chromatograms chromatogram NOUN eurjchem-11 105 10     SPACE eurjchem-11 105 11 of of ADP eurjchem-11 105 12     SPACE eurjchem-11 105 13 the the DET eurjchem-11 105 14     SPACE eurjchem-11 105 15 aripiprazole aripiprazole NOUN eurjchem-11 105 16     SPACE eurjchem-11 105 17 tablet tablet NOUN eurjchem-11 105 18     SPACE eurjchem-11 105 19 sample sample NOUN eurjchem-11 105 20     SPACE eurjchem-11 105 21 under under ADP eurjchem-11 105 22     SPACE eurjchem-11 105 23 the the DET eurjchem-11 105 24     SPACE eurjchem-11 105 25 thermal thermal ADJ eurjchem-11 105 26     SPACE eurjchem-11 105 27 degradation degradation NOUN eurjchem-11 105 28     SPACE eurjchem-11 105 29 condition condition NOUN eurjchem-11 105 30 , , PUNCT eurjchem-11 105 31     SPACE eurjchem-11 105 32 the the DET eurjchem-11 105 33     SPACE eurjchem-11 105 34 unknown unknown ADJ eurjchem-11 105 35     SPACE eurjchem-11 105 36 impurities impurity NOUN eurjchem-11 105 37     SPACE eurjchem-11 105 38 were be AUX eurjchem-11 105 39     SPACE eurjchem-11 105 40 detected detect VERB eurjchem-11 105 41     SPACE eurjchem-11 105 42 at at ADP eurjchem-11 105 43     SPACE eurjchem-11 105 44 rrts rrt NOUN eurjchem-11 105 45     SPACE eurjchem-11 105 46 of of ADP eurjchem-11 105 47     SPACE eurjchem-11 105 48 0.45 0.45 NUM eurjchem-11 105 49 , , PUNCT eurjchem-11 105 50     SPACE eurjchem-11 105 51 1.06 1.06 NUM eurjchem-11 105 52     SPACE eurjchem-11 105 53 and and CCONJ eurjchem-11 105 54     SPACE eurjchem-11 105 55 1.14 1.14 NUM eurjchem-11 105 56     SPACE eurjchem-11 105 57 with with ADP eurjchem-11 105 58     SPACE eurjchem-11 105 59 respect respect NOUN eurjchem-11 105 60     SPACE eurjchem-11 105 61 to to ADP eurjchem-11 105 62     SPACE eurjchem-11 105 63 aripiprazole aripiprazole PROPN eurjchem-11 105 64     SPACE eurjchem-11 105 65 rt rt PROPN eurjchem-11 105 66 . . PROPN eurjchem-11 105 67     SPACE eurjchem-11 105 68 table table NOUN eurjchem-11 105 69     SPACE eurjchem-11 105 70 3 3 NUM eurjchem-11 105 71     SPACE eurjchem-11 105 72 describes describe VERB eurjchem-11 105 73     SPACE eurjchem-11 105 74 the the DET eurjchem-11 105 75     SPACE eurjchem-11 105 76 rts rt NOUN eurjchem-11 105 77 , , PUNCT eurjchem-11 105 78     SPACE eurjchem-11 105 79 rrts rrt NOUN eurjchem-11 105 80 , , PUNCT eurjchem-11 105 81     SPACE eurjchem-11 105 82 m m PROPN eurjchem-11 105 83 / / SYM eurjchem-11 105 84 z z NOUN eurjchem-11 105 85     SPACE eurjchem-11 105 86 values value NOUN eurjchem-11 105 87     SPACE eurjchem-11 105 88 of of ADP eurjchem-11 105 89     SPACE eurjchem-11 105 90 molecular molecular ADJ eurjchem-11 105 91     SPACE eurjchem-11 105 92 ion ion NOUN eurjchem-11 105 93     SPACE eurjchem-11 105 94 peaks peak NOUN eurjchem-11 105 95     SPACE eurjchem-11 105 96 and and CCONJ eurjchem-11 105 97     SPACE eurjchem-11 105 98 their their PRON eurjchem-11 105 99     SPACE eurjchem-11 105 100 major major ADJ eurjchem-11 105 101     SPACE eurjchem-11 105 102 fragment fragment NOUN eurjchem-11 105 103     SPACE eurjchem-11 105 104 ions ion NOUN eurjchem-11 105 105     SPACE eurjchem-11 105 106 corresponding corresponding NOUN eurjchem-11 105 107     SPACE eurjchem-11 105 108 to to ADP eurjchem-11 105 109     SPACE eurjchem-11 105 110 the the DET eurjchem-11 105 111     SPACE eurjchem-11 105 112 unknown unknown ADJ eurjchem-11 105 113     SPACE eurjchem-11 105 114 impurities impurity NOUN eurjchem-11 105 115     SPACE eurjchem-11 105 116 ( ( PUNCT eurjchem-11 105 117 degradation degradation NOUN eurjchem-11 105 118     SPACE eurjchem-11 105 119 products product NOUN eurjchem-11 105 120 ) ) PUNCT eurjchem-11 105 121 . . PUNCT eurjchem-11 105 122     SPACE eurjchem-11 106 1 based base VERB eurjchem-11 106 2     SPACE eurjchem-11 106 3 on on ADP eurjchem-11 106 4     SPACE eurjchem-11 106 5 rrts rrt NOUN eurjchem-11 106 6     SPACE eurjchem-11 106 7 and and CCONJ eurjchem-11 106 8     SPACE eurjchem-11 106 9 m m PROPN eurjchem-11 106 10 / / SYM eurjchem-11 106 11 z z NOUN eurjchem-11 106 12     SPACE eurjchem-11 106 13 values value NOUN eurjchem-11 106 14     SPACE eurjchem-11 106 15 of of ADP eurjchem-11 106 16     SPACE eurjchem-11 106 17 molecular molecular ADJ eurjchem-11 106 18     SPACE eurjchem-11 106 19 ion ion NOUN eurjchem-11 106 20     SPACE eurjchem-11 106 21 peaks peak NOUN eurjchem-11 106 22 , , PUNCT eurjchem-11 106 23     SPACE eurjchem-11 106 24 the the DET eurjchem-11 106 25     SPACE eurjchem-11 106 26 existence existence NOUN eurjchem-11 106 27     SPACE eurjchem-11 106 28 of of ADP eurjchem-11 106 29     SPACE eurjchem-11 106 30 three three NUM eurjchem-11 106 31     SPACE eurjchem-11 106 32 unknown unknown ADJ eurjchem-11 106 33     SPACE eurjchem-11 106 34 impurities impurity NOUN eurjchem-11 106 35     SPACE eurjchem-11 106 36 can can AUX eurjchem-11 106 37     SPACE eurjchem-11 106 38 be be AUX eurjchem-11 106 39     SPACE eurjchem-11 106 40 confirmed confirm VERB eurjchem-11 106 41 . . PUNCT eurjchem-11 106 42     SPACE eurjchem-11 106 43 in in ADP eurjchem-11 106 44     SPACE eurjchem-11 106 45 thermal thermal ADJ eurjchem-11 106 46     SPACE eurjchem-11 106 47 degradation degradation NOUN eurjchem-11 106 48     SPACE eurjchem-11 106 49 condition condition NOUN eurjchem-11 106 50 , , PUNCT eurjchem-11 106 51     SPACE eurjchem-11 106 52 the the DET eurjchem-11 106 53     SPACE eurjchem-11 106 54 aripiprazole aripiprazole NOUN eurjchem-11 106 55     SPACE eurjchem-11 106 56 tablet tablet NOUN eurjchem-11 106 57     SPACE eurjchem-11 106 58 sample sample NOUN eurjchem-11 106 59     SPACE eurjchem-11 106 60 undergone undergone ADJ eurjchem-11 106 61     SPACE eurjchem-11 106 62 major major ADJ eurjchem-11 106 63     SPACE eurjchem-11 106 64 degradation degradation NOUN eurjchem-11 106 65     SPACE eurjchem-11 106 66 and and CCONJ eurjchem-11 106 67     SPACE eurjchem-11 106 68 three three NUM eurjchem-11 106 69     SPACE eurjchem-11 106 70 unknown unknown ADJ eurjchem-11 106 71     SPACE eurjchem-11 106 72 impurities impurity NOUN eurjchem-11 106 73     SPACE eurjchem-11 106 74 were be AUX eurjchem-11 106 75     SPACE eurjchem-11 106 76 detected detect VERB eurjchem-11 106 77 . . PUNCT eurjchem-11 106 78         SPACE eurjchem-11 107 1 3.10 3.10 NUM eurjchem-11 107 2 . . PUNCT eurjchem-11 107 3     SPACE eurjchem-11 107 4 structural structural ADJ eurjchem-11 107 5     SPACE eurjchem-11 107 6 elucidation elucidation NOUN eurjchem-11 107 7     SPACE eurjchem-11 107 8 of of ADP eurjchem-11 107 9     SPACE eurjchem-11 107 10 the the DET eurjchem-11 107 11     SPACE eurjchem-11 107 12 unknown unknown ADJ eurjchem-11 107 13     SPACE eurjchem-11 107 14 impurities impurity NOUN eurjchem-11 107 15         SPACE eurjchem-11 107 16 from from ADP eurjchem-11 107 17     SPACE eurjchem-11 107 18 the the DET eurjchem-11 107 19     SPACE eurjchem-11 107 20 degradation degradation NOUN eurjchem-11 107 21     SPACE eurjchem-11 107 22 studies study NOUN eurjchem-11 107 23 , , PUNCT eurjchem-11 107 24     SPACE eurjchem-11 107 25 three three NUM eurjchem-11 107 26     SPACE eurjchem-11 107 27 unknown unknown ADJ eurjchem-11 107 28     SPACE eurjchem-11 107 29 impurities impurity NOUN eurjchem-11 107 30     SPACE eurjchem-11 107 31 were be AUX eurjchem-11 107 32     SPACE eurjchem-11 107 33 identified identify VERB eurjchem-11 107 34     SPACE eurjchem-11 107 35 at at ADP eurjchem-11 107 36     SPACE eurjchem-11 107 37 rrts rrt NOUN eurjchem-11 107 38     SPACE eurjchem-11 107 39 0.451 0.451 NUM eurjchem-11 107 40 , , PUNCT eurjchem-11 107 41     SPACE eurjchem-11 107 42 1.061 1.061 NUM eurjchem-11 107 43     SPACE eurjchem-11 107 44 and and CCONJ eurjchem-11 107 45     SPACE eurjchem-11 107 46 1.141 1.141 NUM eurjchem-11 107 47     SPACE eurjchem-11 107 48 with with ADP eurjchem-11 107 49     SPACE eurjchem-11 107 50 respect respect NOUN eurjchem-11 107 51     SPACE eurjchem-11 107 52 to to ADP eurjchem-11 107 53     SPACE eurjchem-11 107 54 aripiprazole aripiprazole NOUN eurjchem-11 107 55     SPACE eurjchem-11 107 56 rt rt PROPN eurjchem-11 107 57 . . PUNCT eurjchem-11 107 58     SPACE eurjchem-11 107 59 the the DET eurjchem-11 107 60     SPACE eurjchem-11 107 61 fragmentation fragmentation NOUN eurjchem-11 107 62     SPACE eurjchem-11 107 63 pattern pattern NOUN eurjchem-11 107 64     SPACE eurjchem-11 107 65 of of ADP eurjchem-11 107 66     SPACE eurjchem-11 107 67 the the DET eurjchem-11 107 68     SPACE eurjchem-11 107 69 aripiprazole aripiprazole NOUN eurjchem-11 107 70     SPACE eurjchem-11 107 71 could could AUX eurjchem-11 107 72     SPACE eurjchem-11 107 73 give give VERB eurjchem-11 107 74     SPACE eurjchem-11 107 75 some some DET eurjchem-11 107 76     SPACE eurjchem-11 107 77 information information NOUN eurjchem-11 107 78     SPACE eurjchem-11 107 79 regarding regard VERB eurjchem-11 107 80     SPACE eurjchem-11 107 81 the the DET eurjchem-11 107 82     SPACE eurjchem-11 107 83 structural structural ADJ eurjchem-11 107 84     SPACE eurjchem-11 107 85 elucidation elucidation NOUN eurjchem-11 107 86     SPACE eurjchem-11 107 87 of of ADP eurjchem-11 107 88     SPACE eurjchem-11 107 89 the the DET eurjchem-11 107 90     SPACE eurjchem-11 107 91 unknown unknown ADJ eurjchem-11 107 92     SPACE eurjchem-11 107 93 impurities impurity NOUN eurjchem-11 107 94 . . PUNCT eurjchem-11 107 95     SPACE eurjchem-11 108 1 the the DET eurjchem-11 108 2     SPACE eurjchem-11 108 3 ms ms NOUN eurjchem-11 108 4     SPACE eurjchem-11 108 5 and and CCONJ eurjchem-11 108 6     SPACE eurjchem-11 108 7 ms ms PROPN eurjchem-11 108 8 / / SYM eurjchem-11 108 9 ms ms PROPN eurjchem-11 108 10     SPACE eurjchem-11 108 11 spectra spectra NOUN eurjchem-11 108 12     SPACE eurjchem-11 108 13 of of ADP eurjchem-11 108 14     SPACE eurjchem-11 108 15 aripiprazole aripiprazole NOUN eurjchem-11 108 16     SPACE eurjchem-11 108 17 were be AUX eurjchem-11 108 18     SPACE eurjchem-11 108 19 presented present VERB eurjchem-11 108 20     SPACE eurjchem-11 108 21 in in ADP eurjchem-11 108 22     SPACE eurjchem-11 108 23 figure figure NOUN eurjchem-11 108 24     SPACE eurjchem-11 108 25 4 4 NUM eurjchem-11 108 26 . . PUNCT eurjchem-11 108 27     SPACE eurjchem-11 108 28 three three NUM eurjchem-11 108 29     SPACE eurjchem-11 108 30 important important ADJ eurjchem-11 108 31     SPACE eurjchem-11 108 32 fragments fragment NOUN eurjchem-11 108 33     SPACE eurjchem-11 108 34 were be AUX eurjchem-11 108 35     SPACE eurjchem-11 108 36 observed observe VERB eurjchem-11 108 37     SPACE eurjchem-11 108 38 from from ADP eurjchem-11 108 39     SPACE eurjchem-11 108 40 aripiprazole aripiprazole PROPN eurjchem-11 108 41     SPACE eurjchem-11 108 42 ms ms PROPN eurjchem-11 108 43 / / SYM eurjchem-11 108 44 ms ms PROPN eurjchem-11 108 45     SPACE eurjchem-11 108 46 spectrum spectrum NOUN eurjchem-11 108 47     SPACE eurjchem-11 108 48 and and CCONJ eurjchem-11 108 49     SPACE eurjchem-11 108 50 were be AUX eurjchem-11 108 51     SPACE eurjchem-11 108 52 at at ADP eurjchem-11 108 53     SPACE eurjchem-11 108 54 m m PROPN eurjchem-11 108 55 / / PROPN eurjchem-11 108 56 z z NOUN eurjchem-11 108 57     SPACE eurjchem-11 108 58 values value NOUN eurjchem-11 108 59     SPACE eurjchem-11 108 60 of of ADP eurjchem-11 108 61     SPACE eurjchem-11 108 62 285 285 NUM eurjchem-11 108 63 , , PUNCT eurjchem-11 108 64     SPACE eurjchem-11 108 65 218 218 NUM eurjchem-11 108 66     SPACE eurjchem-11 108 67 and and CCONJ eurjchem-11 108 68     SPACE eurjchem-11 108 69 176 176 NUM eurjchem-11 108 70 . . PUNCT eurjchem-11 108 71     SPACE eurjchem-11 109 1 the the DET eurjchem-11 109 2     SPACE eurjchem-11 109 3 m m PROPN eurjchem-11 109 4 / / PROPN eurjchem-11 109 5 z z NOUN eurjchem-11 109 6     SPACE eurjchem-11 109 7 at at ADP eurjchem-11 109 8     SPACE eurjchem-11 109 9 285 285 NUM eurjchem-11 109 10     SPACE eurjchem-11 109 11 was be AUX eurjchem-11 109 12     SPACE eurjchem-11 109 13 due due ADJ eurjchem-11 109 14     SPACE eurjchem-11 109 15 to to ADP eurjchem-11 109 16     SPACE eurjchem-11 109 17 the the DET eurjchem-11 109 18     SPACE eurjchem-11 109 19 loss loss NOUN eurjchem-11 109 20     SPACE eurjchem-11 109 21 of of ADP eurjchem-11 109 22     SPACE eurjchem-11 109 23 7‐hydroxyquinol 7‐hydroxyquinol NUM eurjchem-11 109 24     SPACE eurjchem-11 109 25 moiety moiety NOUN eurjchem-11 109 26     SPACE eurjchem-11 109 27 from from ADP eurjchem-11 109 28     SPACE eurjchem-11 109 29 the the DET eurjchem-11 109 30     SPACE eurjchem-11 109 31 aripiprazole aripiprazole NOUN eurjchem-11 109 32     SPACE eurjchem-11 109 33 and and CCONJ eurjchem-11 109 34     SPACE eurjchem-11 109 35 m m PROPN eurjchem-11 109 36 / / PROPN eurjchem-11 109 37 z z NOUN eurjchem-11 109 38     SPACE eurjchem-11 109 39 at at ADP eurjchem-11 109 40     SPACE eurjchem-11 109 41 218 218 NUM eurjchem-11 109 42     SPACE eurjchem-11 109 43 was be AUX eurjchem-11 109 44     SPACE eurjchem-11 109 45 due due ADJ eurjchem-11 109 46     SPACE eurjchem-11 109 47 to to ADP eurjchem-11 109 48     SPACE eurjchem-11 109 49 the the DET eurjchem-11 109 50     SPACE eurjchem-11 109 51 lack lack NOUN eurjchem-11 109 52     SPACE eurjchem-11 109 53 of of ADP eurjchem-11 109 54     SPACE eurjchem-11 109 55 dichlorophenyl dichlorophenyl NOUN eurjchem-11 109 56     SPACE eurjchem-11 109 57 piperazine piperazine NOUN eurjchem-11 109 58     SPACE eurjchem-11 109 59 ring ring NOUN eurjchem-11 109 60 . . PUNCT eurjchem-11 109 61     SPACE eurjchem-11 110 1 the the DET eurjchem-11 110 2     SPACE eurjchem-11 110 3 fragment fragment NOUN eurjchem-11 110 4     SPACE eurjchem-11 110 5 at at ADP eurjchem-11 110 6     SPACE eurjchem-11 110 7 m m PROPN eurjchem-11 110 8 / / PROPN eurjchem-11 110 9 z z NOUN eurjchem-11 110 10     SPACE eurjchem-11 110 11 176 176 NUM eurjchem-11 110 12     SPACE eurjchem-11 110 13 was be AUX eurjchem-11 110 14     SPACE eurjchem-11 110 15 obtained obtain VERB eurjchem-11 110 16     SPACE eurjchem-11 110 17 by by ADP eurjchem-11 110 18     SPACE eurjchem-11 110 19 the the DET eurjchem-11 110 20     SPACE eurjchem-11 110 21 removal removal NOUN eurjchem-11 110 22     SPACE eurjchem-11 110 23 of of ADP eurjchem-11 110 24     SPACE eurjchem-11 110 25 1‐(2,3‐dichlorophenyl)‐4‐propyl 1‐(2,3‐dichlorophenyl)‐4‐propyl NUM eurjchem-11 110 26     SPACE eurjchem-11 110 27 piperzine piperzine NOUN eurjchem-11 110 28     SPACE eurjchem-11 110 29 moiety moiety NOUN eurjchem-11 110 30 . . PUNCT eurjchem-11 110 31     SPACE eurjchem-11 111 1 the the DET eurjchem-11 111 2     SPACE eurjchem-11 111 3 fragmentation fragmentation NOUN eurjchem-11 111 4     SPACE eurjchem-11 111 5 pattern pattern NOUN eurjchem-11 111 6     SPACE eurjchem-11 111 7 of of ADP eurjchem-11 111 8     SPACE eurjchem-11 111 9 aripiprazole aripiprazole NOUN eurjchem-11 111 10     SPACE eurjchem-11 111 11 was be AUX eurjchem-11 111 12     SPACE eurjchem-11 111 13 presented present VERB eurjchem-11 111 14     SPACE eurjchem-11 111 15 in in ADP eurjchem-11 111 16     SPACE eurjchem-11 111 17 scheme scheme NOUN eurjchem-11 111 18     SPACE eurjchem-11 111 19 1 1 NUM eurjchem-11 111 20 . . PUNCT eurjchem-11 111 21     SPACE eurjchem-11 111 22 figure figure NOUN eurjchem-11 111 23     SPACE eurjchem-11 111 24 5 5 NUM eurjchem-11 111 25     SPACE eurjchem-11 111 26 shows show VERB eurjchem-11 111 27     SPACE eurjchem-11 111 28 ms ms NOUN eurjchem-11 111 29     SPACE eurjchem-11 111 30 and and CCONJ eurjchem-11 111 31     SPACE eurjchem-11 111 32 ms ms PROPN eurjchem-11 111 33 / / SYM eurjchem-11 111 34 ms ms PROPN eurjchem-11 111 35     SPACE eurjchem-11 111 36 spectra spectra NOUN eurjchem-11 111 37     SPACE eurjchem-11 111 38 of of ADP eurjchem-11 111 39     SPACE eurjchem-11 111 40 the the DET eurjchem-11 111 41     SPACE eurjchem-11 111 42 unknown unknown ADJ eurjchem-11 111 43     SPACE eurjchem-11 111 44 impurity impurity NOUN eurjchem-11 111 45     SPACE eurjchem-11 111 46 at at ADP eurjchem-11 111 47     SPACE eurjchem-11 111 48 rrt rrt NOUN eurjchem-11 111 49     SPACE eurjchem-11 111 50 0.45 0.45 NUM eurjchem-11 111 51     SPACE eurjchem-11 111 52 from from ADP eurjchem-11 111 53     SPACE eurjchem-11 111 54 thermal thermal ADJ eurjchem-11 111 55     SPACE eurjchem-11 111 56 degradation degradation NOUN eurjchem-11 111 57     SPACE eurjchem-11 111 58 of of ADP eurjchem-11 111 59     SPACE eurjchem-11 111 60 aripiprazole aripiprazole NOUN eurjchem-11 111 61     SPACE eurjchem-11 111 62 tablet tablet NOUN eurjchem-11 111 63     SPACE eurjchem-11 111 64 sample sample NOUN eurjchem-11 111 65 . . PUNCT eurjchem-11 111 66     SPACE eurjchem-11 111 67 in in ADP eurjchem-11 111 68     SPACE eurjchem-11 111 69 the the DET eurjchem-11 111 70     SPACE eurjchem-11 111 71 ms ms PROPN eurjchem-11 111 72     SPACE eurjchem-11 111 73 spectrum spectrum NOUN eurjchem-11 111 74     SPACE eurjchem-11 111 75 of of ADP eurjchem-11 111 76     SPACE eurjchem-11 111 77 this this DET eurjchem-11 111 78     SPACE eurjchem-11 111 79 unknown unknown ADJ eurjchem-11 111 80     SPACE eurjchem-11 111 81 impurity impurity NOUN eurjchem-11 111 82 , , PUNCT eurjchem-11 111 83     SPACE eurjchem-11 111 84 dichloro dichloro PROPN eurjchem-11 111 85     SPACE eurjchem-11 111 86 isotopic isotopic NOUN eurjchem-11 111 87     SPACE eurjchem-11 111 88 peaks peak NOUN eurjchem-11 111 89     SPACE eurjchem-11 111 90 were be AUX eurjchem-11 111 91     SPACE eurjchem-11 111 92 observed observe VERB eurjchem-11 111 93     SPACE eurjchem-11 111 94 at at ADP eurjchem-11 111 95     SPACE eurjchem-11 111 96 m m PROPN eurjchem-11 111 97 / / PROPN eurjchem-11 112 1 z z NOUN eurjchem-11 112 2     SPACE eurjchem-11 112 3 285 285 NUM eurjchem-11 112 4     SPACE eurjchem-11 112 5 and and CCONJ eurjchem-11 112 6     SPACE eurjchem-11 112 7 287 287 NUM eurjchem-11 112 8     SPACE eurjchem-11 112 9 having have VERB eurjchem-11 112 10     SPACE eurjchem-11 112 11 the the DET eurjchem-11 112 12     SPACE eurjchem-11 112 13 intensity intensity NOUN eurjchem-11 112 14     SPACE eurjchem-11 112 15 in in ADP eurjchem-11 112 16     SPACE eurjchem-11 112 17 the the DET eurjchem-11 112 18     SPACE eurjchem-11 112 19 ratio ratio NOUN eurjchem-11 112 20     SPACE eurjchem-11 112 21 of of ADP eurjchem-11 112 22       SPACE eurjchem-11 112 23 3:2 3:2 NUM eurjchem-11 112 24 , , PUNCT eurjchem-11 112 25     SPACE eurjchem-11 112 26 which which PRON eurjchem-11 112 27     SPACE eurjchem-11 112 28 proves prove VERB eurjchem-11 112 29       SPACE eurjchem-11 112 30 that that SCONJ eurjchem-11 112 31       SPACE eurjchem-11 112 32 this this PRON eurjchem-11 112 33         SPACE eurjchem-11 112 34 ( ( PUNCT eurjchem-11 112 35 a a X eurjchem-11 112 36 ) ) PUNCT eurjchem-11 112 37         SPACE eurjchem-11 112 38 ( ( PUNCT eurjchem-11 112 39 b b NOUN eurjchem-11 112 40 ) ) PUNCT eurjchem-11 112 41             SPACE eurjchem-11 112 42 figure figure NOUN eurjchem-11 112 43     SPACE eurjchem-11 112 44 4 4 NUM eurjchem-11 112 45 . . PUNCT eurjchem-11 112 46     SPACE eurjchem-11 112 47 ms ms PROPN eurjchem-11 112 48     SPACE eurjchem-11 112 49 ( ( PUNCT eurjchem-11 112 50 a a NOUN eurjchem-11 112 51 ) ) PUNCT eurjchem-11 112 52     SPACE eurjchem-11 112 53 and and CCONJ eurjchem-11 112 54     SPACE eurjchem-11 112 55 ms ms PROPN eurjchem-11 112 56 / / SYM eurjchem-11 112 57 ms ms NOUN eurjchem-11 112 58     SPACE eurjchem-11 112 59 ( ( PUNCT eurjchem-11 112 60 b b NOUN eurjchem-11 112 61 ) ) PUNCT eurjchem-11 112 62     SPACE eurjchem-11 112 63 spectra spectra NOUN eurjchem-11 112 64     SPACE eurjchem-11 112 65 of of ADP eurjchem-11 112 66     SPACE eurjchem-11 112 67 the the DET eurjchem-11 112 68     SPACE eurjchem-11 112 69 aripiprazole aripiprazole NOUN eurjchem-11 112 70     SPACE eurjchem-11 112 71 reddy reddy PROPN eurjchem-11 112 72     SPACE eurjchem-11 112 73 et et PROPN eurjchem-11 112 74     SPACE eurjchem-11 112 75 al al PROPN eurjchem-11 112 76 . . PROPN eurjchem-11 112 77     SPACE eurjchem-11 112 78 / / SYM eurjchem-11 112 79     SPACE eurjchem-11 112 80 european european ADJ eurjchem-11 112 81     SPACE eurjchem-11 112 82 journal journal NOUN eurjchem-11 112 83     SPACE eurjchem-11 112 84 of of ADP eurjchem-11 112 85     SPACE eurjchem-11 112 86 chemistry chemistry NOUN eurjchem-11 112 87     SPACE eurjchem-11 112 88 1 1 NUM eurjchem-11 112 89     SPACE eurjchem-11 112 90 ( ( PUNCT eurjchem-11 112 91 1 1 NUM eurjchem-11 112 92 ) ) PUNCT eurjchem-11 112 93     SPACE eurjchem-11 112 94 ( ( PUNCT eurjchem-11 112 95 2010 2010 NUM eurjchem-11 112 96 ) ) PUNCT eurjchem-11 112 97     SPACE eurjchem-11 112 98 20­27 20­27 NUM eurjchem-11 112 99     SPACE eurjchem-11 112 100 25 25 NUM eurjchem-11 112 101     SPACE eurjchem-11 112 102 degradation degradation NOUN eurjchem-11 112 103     SPACE eurjchem-11 112 104 impurity impurity NOUN eurjchem-11 112 105     SPACE eurjchem-11 112 106 possess possess NOUN eurjchem-11 112 107     SPACE eurjchem-11 112 108 two two NUM eurjchem-11 112 109     SPACE eurjchem-11 112 110 chlorine chlorine NOUN eurjchem-11 112 111     SPACE eurjchem-11 112 112 atoms atom NOUN eurjchem-11 112 113     SPACE eurjchem-11 112 114 in in ADP eurjchem-11 112 115     SPACE eurjchem-11 112 116 its its PRON eurjchem-11 112 117     SPACE eurjchem-11 112 118 structure structure NOUN eurjchem-11 112 119 . . PUNCT eurjchem-11 112 120     SPACE eurjchem-11 113 1 the the DET eurjchem-11 113 2     SPACE eurjchem-11 113 3 major major ADJ eurjchem-11 113 4     SPACE eurjchem-11 113 5 fragments fragment NOUN eurjchem-11 113 6     SPACE eurjchem-11 113 7 of of ADP eurjchem-11 113 8     SPACE eurjchem-11 113 9 this this DET eurjchem-11 113 10     SPACE eurjchem-11 113 11 unknown unknown ADJ eurjchem-11 113 12     SPACE eurjchem-11 113 13 impurity impurity NOUN eurjchem-11 113 14     SPACE eurjchem-11 113 15 observed observe VERB eurjchem-11 113 16     SPACE eurjchem-11 113 17 were be AUX eurjchem-11 113 18     SPACE eurjchem-11 113 19 at at ADP eurjchem-11 113 20     SPACE eurjchem-11 113 21 m m PROPN eurjchem-11 113 22 / / PROPN eurjchem-11 113 23 z z NOUN eurjchem-11 113 24     SPACE eurjchem-11 113 25 231 231 NUM eurjchem-11 113 26 , , PUNCT eurjchem-11 113 27     SPACE eurjchem-11 113 28 188 188 NUM eurjchem-11 113 29     SPACE eurjchem-11 113 30 and and CCONJ eurjchem-11 113 31     SPACE eurjchem-11 113 32 154 154 NUM eurjchem-11 113 33 . . PUNCT eurjchem-11 113 34     SPACE eurjchem-11 114 1 the the DET eurjchem-11 114 2     SPACE eurjchem-11 114 3 fragments fragment NOUN eurjchem-11 114 4     SPACE eurjchem-11 114 5 at at ADP eurjchem-11 114 6     SPACE eurjchem-11 114 7 m m PROPN eurjchem-11 114 8 / / PROPN eurjchem-11 114 9 z z NOUN eurjchem-11 114 10     SPACE eurjchem-11 114 11 231 231 NUM eurjchem-11 114 12     SPACE eurjchem-11 114 13 was be AUX eurjchem-11 114 14     SPACE eurjchem-11 114 15 obtained obtain VERB eurjchem-11 114 16     SPACE eurjchem-11 114 17 due due ADJ eurjchem-11 114 18     SPACE eurjchem-11 114 19 to to PART eurjchem-11 114 20     SPACE eurjchem-11 114 21 loss loss NOUN eurjchem-11 114 22     SPACE eurjchem-11 114 23 of of ADP eurjchem-11 114 24     SPACE eurjchem-11 114 25 1‐butene 1‐butene NUM eurjchem-11 114 26 , , PUNCT eurjchem-11 114 27     SPACE eurjchem-11 114 28 m m PROPN eurjchem-11 114 29 / / SYM eurjchem-11 114 30 z z NOUN eurjchem-11 114 31     SPACE eurjchem-11 114 32 188 188 NUM eurjchem-11 114 33     SPACE eurjchem-11 114 34 was be AUX eurjchem-11 114 35     SPACE eurjchem-11 114 36 due due ADJ eurjchem-11 114 37     SPACE eurjchem-11 114 38 to to PART eurjchem-11 114 39     SPACE eurjchem-11 114 40 loss loss NOUN eurjchem-11 114 41     SPACE eurjchem-11 114 42 of of ADP eurjchem-11 114 43     SPACE eurjchem-11 114 44 n n CCONJ eurjchem-11 114 45 , , PUNCT eurjchem-11 114 46 n‐dimethyl‐1‐butene n‐dimethyl‐1‐butene NOUN eurjchem-11 114 47     SPACE eurjchem-11 114 48 and and CCONJ eurjchem-11 114 49     SPACE eurjchem-11 114 50 m m PROPN eurjchem-11 114 51 / / PROPN eurjchem-11 114 52 z z NOUN eurjchem-11 114 53     SPACE eurjchem-11 114 54 154 154 NUM eurjchem-11 114 55     SPACE eurjchem-11 114 56 was be AUX eurjchem-11 114 57     SPACE eurjchem-11 114 58 due due ADJ eurjchem-11 114 59     SPACE eurjchem-11 114 60 to to PART eurjchem-11 114 61     SPACE eurjchem-11 114 62 lack lack VERB eurjchem-11 114 63     SPACE eurjchem-11 114 64 of of ADP eurjchem-11 114 65     SPACE eurjchem-11 114 66 n n CCONJ eurjchem-11 114 67 , , PUNCT eurjchem-11 114 68 n‐dimethyl‐1‐butene n‐dimethyl‐1‐butene NOUN eurjchem-11 114 69     SPACE eurjchem-11 114 70 along along ADP eurjchem-11 114 71     SPACE eurjchem-11 114 72 with with ADP eurjchem-11 114 73     SPACE eurjchem-11 114 74 chlorine chlorine NOUN eurjchem-11 114 75 . . PUNCT eurjchem-11 114 76     SPACE eurjchem-11 115 1 the the DET eurjchem-11 115 2     SPACE eurjchem-11 115 3 fragmentation fragmentation NOUN eurjchem-11 115 4     SPACE eurjchem-11 115 5 pattern pattern NOUN eurjchem-11 115 6     SPACE eurjchem-11 115 7 of of ADP eurjchem-11 115 8     SPACE eurjchem-11 115 9 this this DET eurjchem-11 115 10     SPACE eurjchem-11 115 11 unknown unknown ADJ eurjchem-11 115 12     SPACE eurjchem-11 115 13 impurity impurity NOUN eurjchem-11 115 14     SPACE eurjchem-11 115 15 and and CCONJ eurjchem-11 115 16     SPACE eurjchem-11 115 17 its its PRON eurjchem-11 115 18     SPACE eurjchem-11 115 19 possible possible ADJ eurjchem-11 115 20     SPACE eurjchem-11 115 21 structure structure NOUN eurjchem-11 115 22     SPACE eurjchem-11 115 23 were be AUX eurjchem-11 115 24     SPACE eurjchem-11 115 25 presented present VERB eurjchem-11 115 26     SPACE eurjchem-11 115 27 in in ADP eurjchem-11 115 28     SPACE eurjchem-11 115 29 scheme scheme NOUN eurjchem-11 115 30     SPACE eurjchem-11 115 31 2 2 NUM eurjchem-11 115 32 . . PUNCT eurjchem-11 115 33       SPACE eurjchem-11 115 34 the the DET eurjchem-11 115 35     SPACE eurjchem-11 115 36 peak peak NOUN eurjchem-11 115 37     SPACE eurjchem-11 115 38 at at ADP eurjchem-11 115 39     SPACE eurjchem-11 115 40 rrt rrt NOUN eurjchem-11 115 41     SPACE eurjchem-11 115 42 1.06 1.06 NUM eurjchem-11 115 43     SPACE eurjchem-11 115 44 showed show VERB eurjchem-11 115 45     SPACE eurjchem-11 115 46 the the DET eurjchem-11 115 47     SPACE eurjchem-11 115 48 molecular molecular ADJ eurjchem-11 115 49     SPACE eurjchem-11 115 50 ion ion NOUN eurjchem-11 115 51     SPACE eurjchem-11 115 52 at at ADP eurjchem-11 115 53     SPACE eurjchem-11 115 54 m m PROPN eurjchem-11 115 55 / / PROPN eurjchem-11 116 1 z z NOUN eurjchem-11 116 2     SPACE eurjchem-11 116 3 464 464 NUM eurjchem-11 116 4     SPACE eurjchem-11 116 5 in in ADP eurjchem-11 116 6     SPACE eurjchem-11 116 7 the the DET eurjchem-11 116 8     SPACE eurjchem-11 116 9 ms ms PROPN eurjchem-11 116 10     SPACE eurjchem-11 116 11 spectrum spectrum NOUN eurjchem-11 116 12     SPACE eurjchem-11 116 13 of of ADP eurjchem-11 116 14     SPACE eurjchem-11 116 15 thermal thermal ADJ eurjchem-11 116 16     SPACE eurjchem-11 116 17 degradation degradation NOUN eurjchem-11 116 18     SPACE eurjchem-11 116 19 sample sample NOUN eurjchem-11 116 20     SPACE eurjchem-11 116 21 ( ( PUNCT eurjchem-11 116 22 figure figure NOUN eurjchem-11 116 23     SPACE eurjchem-11 116 24 6a 6a NOUN eurjchem-11 116 25 ) ) PUNCT eurjchem-11 116 26 . . PUNCT eurjchem-11 116 27     SPACE eurjchem-11 117 1 this this DET eurjchem-11 117 2     SPACE eurjchem-11 117 3 molecular molecular ADJ eurjchem-11 117 4     SPACE eurjchem-11 117 5 ion ion NOUN eurjchem-11 117 6     SPACE eurjchem-11 117 7 mass mass PROPN eurjchem-11 117 8     SPACE eurjchem-11 117 9 was be AUX eurjchem-11 117 10     SPACE eurjchem-11 117 11 16 16 NUM eurjchem-11 117 12     SPACE eurjchem-11 117 13 mass mass PROPN eurjchem-11 117 14     SPACE eurjchem-11 117 15 units unit NOUN eurjchem-11 117 16     SPACE eurjchem-11 117 17 higher high ADJ eurjchem-11 117 18     SPACE eurjchem-11 117 19 than than ADP eurjchem-11 117 20     SPACE eurjchem-11 117 21 that that PRON eurjchem-11 117 22     SPACE eurjchem-11 117 23 of of ADP eurjchem-11 117 24     SPACE eurjchem-11 117 25 aripiprazole aripiprazole NOUN eurjchem-11 117 26     SPACE eurjchem-11 117 27 and and CCONJ eurjchem-11 117 28     SPACE eurjchem-11 117 29 this this PRON eurjchem-11 117 30     SPACE eurjchem-11 117 31 indicates indicate VERB eurjchem-11 117 32     SPACE eurjchem-11 117 33 that that SCONJ eurjchem-11 117 34     SPACE eurjchem-11 117 35 the the DET eurjchem-11 117 36     SPACE eurjchem-11 117 37 probability probability NOUN eurjchem-11 117 38     SPACE eurjchem-11 117 39 to to ADP eurjchem-11 117 40     SPACE eurjchem-11 117 41 the the DET eurjchem-11 117 42     SPACE eurjchem-11 117 43 formation formation NOUN eurjchem-11 117 44     SPACE eurjchem-11 117 45 of of ADP eurjchem-11 117 46     SPACE eurjchem-11 117 47 n‐oxide n‐oxide PROPN eurjchem-11 117 48 . . PUNCT eurjchem-11 117 49     SPACE eurjchem-11 117 50 the the DET eurjchem-11 117 51     SPACE eurjchem-11 117 52 same same ADJ eurjchem-11 117 53     SPACE eurjchem-11 117 54 impurity impurity NOUN eurjchem-11 117 55     SPACE eurjchem-11 117 56 was be AUX eurjchem-11 117 57     SPACE eurjchem-11 117 58 also also ADV eurjchem-11 117 59     SPACE eurjchem-11 117 60 observed observe VERB eurjchem-11 117 61     SPACE eurjchem-11 117 62 in in ADP eurjchem-11 117 63     SPACE eurjchem-11 117 64 oxidative oxidative ADJ eurjchem-11 117 65     SPACE eurjchem-11 117 66 degradation degradation NOUN eurjchem-11 117 67 , , PUNCT eurjchem-11 117 68     SPACE eurjchem-11 117 69 but but CCONJ eurjchem-11 117 70     SPACE eurjchem-11 117 71 in in ADP eurjchem-11 117 72     SPACE eurjchem-11 117 73 smaller small ADJ eurjchem-11 117 74     SPACE eurjchem-11 117 75 quantities quantity NOUN eurjchem-11 117 76 . . PUNCT eurjchem-11 117 77     SPACE eurjchem-11 118 1 figure figure NOUN eurjchem-11 118 2     SPACE eurjchem-11 118 3 6b 6b NOUN eurjchem-11 118 4     SPACE eurjchem-11 118 5 presents present VERB eurjchem-11 118 6     SPACE eurjchem-11 118 7 the the DET eurjchem-11 118 8     SPACE eurjchem-11 118 9 ms ms PROPN eurjchem-11 118 10 / / SYM eurjchem-11 118 11 ms ms PROPN eurjchem-11 118 12     SPACE eurjchem-11 118 13 spectrum spectrum NOUN eurjchem-11 118 14     SPACE eurjchem-11 118 15 of of ADP eurjchem-11 118 16     SPACE eurjchem-11 118 17 this this DET eurjchem-11 118 18     SPACE eurjchem-11 118 19 unknown unknown ADJ eurjchem-11 118 20     SPACE eurjchem-11 118 21 impurity impurity NOUN eurjchem-11 118 22     SPACE eurjchem-11 118 23 from from ADP eurjchem-11 118 24         SPACE eurjchem-11 118 25 ( ( PUNCT eurjchem-11 118 26 a a X eurjchem-11 118 27 ) ) PUNCT eurjchem-11 118 28             SPACE eurjchem-11 118 29 ( ( PUNCT eurjchem-11 118 30 b b NOUN eurjchem-11 118 31 ) ) PUNCT eurjchem-11 118 32           SPACE eurjchem-11 118 33 figure figure NOUN eurjchem-11 118 34     SPACE eurjchem-11 118 35 5 5 NUM eurjchem-11 118 36 . . PUNCT eurjchem-11 118 37     SPACE eurjchem-11 118 38 ms ms PROPN eurjchem-11 118 39     SPACE eurjchem-11 118 40 ( ( PUNCT eurjchem-11 118 41 a a NOUN eurjchem-11 118 42 ) ) PUNCT eurjchem-11 118 43     SPACE eurjchem-11 118 44 and and CCONJ eurjchem-11 118 45     SPACE eurjchem-11 118 46 ms ms PROPN eurjchem-11 118 47 / / SYM eurjchem-11 118 48 ms ms NOUN eurjchem-11 118 49     SPACE eurjchem-11 118 50 ( ( PUNCT eurjchem-11 118 51 b b NOUN eurjchem-11 118 52 ) ) PUNCT eurjchem-11 118 53     SPACE eurjchem-11 118 54 spectra spectra NOUN eurjchem-11 118 55     SPACE eurjchem-11 118 56 of of ADP eurjchem-11 118 57     SPACE eurjchem-11 118 58 the the DET eurjchem-11 118 59     SPACE eurjchem-11 118 60 unknown unknown ADJ eurjchem-11 118 61     SPACE eurjchem-11 118 62 impurity impurity NOUN eurjchem-11 118 63     SPACE eurjchem-11 118 64 at at ADP eurjchem-11 118 65     SPACE eurjchem-11 118 66 rrt rrt NOUN eurjchem-11 118 67     SPACE eurjchem-11 118 68 0.45 0.45 NUM eurjchem-11 118 69     SPACE eurjchem-11 118 70 in in ADP eurjchem-11 118 71     SPACE eurjchem-11 118 72 thermal thermal ADJ eurjchem-11 118 73     SPACE eurjchem-11 118 74 degradation degradation NOUN eurjchem-11 118 75     SPACE eurjchem-11 118 76 of of ADP eurjchem-11 118 77     SPACE eurjchem-11 118 78 aripiprazole aripiprazole NOUN eurjchem-11 118 79     SPACE eurjchem-11 118 80 tablet tablet NOUN eurjchem-11 118 81     SPACE eurjchem-11 118 82 sample sample NOUN eurjchem-11 118 83 . . PUNCT eurjchem-11 118 84                     SPACE eurjchem-11 118 85 scheme scheme NOUN eurjchem-11 118 86     SPACE eurjchem-11 118 87 1 1 NUM eurjchem-11 118 88 . . PUNCT eurjchem-11 119 1 fragmentation fragmentation NOUN eurjchem-11 119 2     SPACE eurjchem-11 119 3 of of ADP eurjchem-11 119 4       SPACE eurjchem-11 119 5 aripiprazole aripiprazole NOUN eurjchem-11 119 6 . . PUNCT eurjchem-11 119 7     SPACE eurjchem-11 119 8 thermal thermal ADJ eurjchem-11 119 9     SPACE eurjchem-11 119 10 degradation degradation NOUN eurjchem-11 119 11     SPACE eurjchem-11 119 12 sample sample NOUN eurjchem-11 119 13     SPACE eurjchem-11 119 14 of of ADP eurjchem-11 119 15     SPACE eurjchem-11 119 16 aripiprazole aripiprazole NOUN eurjchem-11 119 17     SPACE eurjchem-11 119 18 tablet tablet NOUN eurjchem-11 119 19 . . PUNCT eurjchem-11 119 20     SPACE eurjchem-11 120 1 in in ADP eurjchem-11 120 2     SPACE eurjchem-11 120 3 aripiprazole aripiprazole NOUN eurjchem-11 120 4 , , PUNCT eurjchem-11 120 5     SPACE eurjchem-11 120 6 there there PRON eurjchem-11 120 7     SPACE eurjchem-11 120 8 were be AUX eurjchem-11 120 9     SPACE eurjchem-11 120 10 three three NUM eurjchem-11 120 11     SPACE eurjchem-11 120 12 nitrogen nitrogen NOUN eurjchem-11 120 13     SPACE eurjchem-11 120 14 atoms atom NOUN eurjchem-11 120 15 , , PUNCT eurjchem-11 120 16     SPACE eurjchem-11 120 17 but but CCONJ eurjchem-11 120 18     SPACE eurjchem-11 120 19 the the DET eurjchem-11 120 20     SPACE eurjchem-11 120 21 n‐oxide n‐oxide ADJ eurjchem-11 120 22     SPACE eurjchem-11 120 23 formation formation NOUN eurjchem-11 120 24     SPACE eurjchem-11 120 25 takes take VERB eurjchem-11 120 26     SPACE eurjchem-11 120 27 place place NOUN eurjchem-11 120 28     SPACE eurjchem-11 120 29 at at ADP eurjchem-11 120 30     SPACE eurjchem-11 120 31 the the DET eurjchem-11 120 32     SPACE eurjchem-11 120 33 piperazine piperazine NOUN eurjchem-11 120 34     SPACE eurjchem-11 120 35 ring ring NOUN eurjchem-11 120 36     SPACE eurjchem-11 121 1 [ [ X eurjchem-11 121 2 24 24 NUM eurjchem-11 121 3 ] ] PUNCT eurjchem-11 121 4     SPACE eurjchem-11 121 5 and and CCONJ eurjchem-11 121 6     SPACE eurjchem-11 121 7 was be AUX eurjchem-11 121 8     SPACE eurjchem-11 121 9 proved prove VERB eurjchem-11 121 10     SPACE eurjchem-11 121 11 by by ADP eurjchem-11 121 12     SPACE eurjchem-11 121 13 ms ms PROPN eurjchem-11 121 14 / / SYM eurjchem-11 121 15 ms ms NOUN eurjchem-11 121 16     SPACE eurjchem-11 121 17 study study NOUN eurjchem-11 121 18     SPACE eurjchem-11 121 19 of of ADP eurjchem-11 121 20     SPACE eurjchem-11 121 21 this this DET eurjchem-11 121 22     SPACE eurjchem-11 121 23 impurity impurity NOUN eurjchem-11 121 24 . . PUNCT eurjchem-11 121 25     SPACE eurjchem-11 122 1 the the DET eurjchem-11 122 2     SPACE eurjchem-11 122 3 main main ADJ eurjchem-11 122 4     SPACE eurjchem-11 122 5 fragments fragment NOUN eurjchem-11 122 6     SPACE eurjchem-11 122 7 of of ADP eurjchem-11 122 8     SPACE eurjchem-11 122 9 this this DET eurjchem-11 122 10     SPACE eurjchem-11 122 11 unknown unknown ADJ eurjchem-11 122 12     SPACE eurjchem-11 122 13 impurity impurity NOUN eurjchem-11 122 14     SPACE eurjchem-11 122 15 were be AUX eurjchem-11 122 16     SPACE eurjchem-11 122 17 detected detect VERB eurjchem-11 122 18     SPACE eurjchem-11 122 19 at at ADP eurjchem-11 122 20     SPACE eurjchem-11 122 21 m m PROPN eurjchem-11 122 22 / / PROPN eurjchem-11 122 23 z z NOUN eurjchem-11 122 24     SPACE eurjchem-11 122 25 values value NOUN eurjchem-11 122 26     SPACE eurjchem-11 122 27 of of ADP eurjchem-11 122 28     SPACE eurjchem-11 122 29 285 285 NUM eurjchem-11 122 30 , , PUNCT eurjchem-11 122 31     SPACE eurjchem-11 122 32 243 243 NUM eurjchem-11 122 33 , , PUNCT eurjchem-11 122 34     SPACE eurjchem-11 122 35 218 218 NUM eurjchem-11 122 36 , , PUNCT eurjchem-11 122 37     SPACE eurjchem-11 122 38 178 178 NUM eurjchem-11 122 39     SPACE eurjchem-11 122 40 and and CCONJ eurjchem-11 122 41     SPACE eurjchem-11 122 42 164 164 NUM eurjchem-11 122 43 . . PUNCT eurjchem-11 122 44     SPACE eurjchem-11 122 45 the the DET eurjchem-11 122 46     SPACE eurjchem-11 122 47 fragmentation fragmentation NOUN eurjchem-11 122 48     SPACE eurjchem-11 122 49 pattern pattern NOUN eurjchem-11 122 50     SPACE eurjchem-11 122 51 of of ADP eurjchem-11 122 52     SPACE eurjchem-11 122 53 this this DET eurjchem-11 122 54     SPACE eurjchem-11 122 55 unknown unknown ADJ eurjchem-11 122 56     SPACE eurjchem-11 122 57 impurity impurity NOUN eurjchem-11 122 58     SPACE eurjchem-11 122 59 and and CCONJ eurjchem-11 122 60     SPACE eurjchem-11 122 61 its its PRON eurjchem-11 122 62     SPACE eurjchem-11 122 63 possible possible ADJ eurjchem-11 122 64     SPACE eurjchem-11 122 65 structure structure NOUN eurjchem-11 122 66     SPACE eurjchem-11 122 67 were be AUX eurjchem-11 122 68     SPACE eurjchem-11 122 69 presented present VERB eurjchem-11 122 70     SPACE eurjchem-11 122 71 in in ADP eurjchem-11 122 72     SPACE eurjchem-11 122 73 scheme scheme NOUN eurjchem-11 122 74     SPACE eurjchem-11 122 75 3 3 NUM eurjchem-11 122 76 . . PUNCT eurjchem-11 122 77                 SPACE eurjchem-11 122 78 scheme scheme NOUN eurjchem-11 122 79     SPACE eurjchem-11 122 80 2 2 NUM eurjchem-11 122 81 . . PUNCT eurjchem-11 123 1 fragmentation fragmentation NOUN eurjchem-11 123 2     SPACE eurjchem-11 123 3 of of ADP eurjchem-11 123 4     SPACE eurjchem-11 123 5 the the DET eurjchem-11 123 6     SPACE eurjchem-11 123 7 unknown unknown ADJ eurjchem-11 123 8     SPACE eurjchem-11 123 9 impurity impurity NOUN eurjchem-11 123 10     SPACE eurjchem-11 123 11 at at ADP eurjchem-11 123 12     SPACE eurjchem-11 123 13 rrt rrt NOUN eurjchem-11 123 14     SPACE eurjchem-11 123 15 0.45 0.45 NUM eurjchem-11 123 16 . . PUNCT eurjchem-11 123 17             SPACE eurjchem-11 123 18 ( ( PUNCT eurjchem-11 123 19 a a X eurjchem-11 123 20 ) ) PUNCT eurjchem-11 123 21               SPACE eurjchem-11 123 22 ( ( PUNCT eurjchem-11 123 23 b b NOUN eurjchem-11 123 24 ) ) PUNCT eurjchem-11 123 25             SPACE eurjchem-11 123 26 figure figure NOUN eurjchem-11 123 27     SPACE eurjchem-11 123 28 6 6 NUM eurjchem-11 123 29 . . PUNCT eurjchem-11 123 30     SPACE eurjchem-11 123 31 ms ms PROPN eurjchem-11 123 32     SPACE eurjchem-11 123 33 ( ( PUNCT eurjchem-11 123 34 a a NOUN eurjchem-11 123 35 ) ) PUNCT eurjchem-11 123 36     SPACE eurjchem-11 123 37 and and CCONJ eurjchem-11 123 38     SPACE eurjchem-11 123 39 ms ms PROPN eurjchem-11 123 40 / / SYM eurjchem-11 123 41 ms ms NOUN eurjchem-11 123 42     SPACE eurjchem-11 123 43 ( ( PUNCT eurjchem-11 123 44 b b NOUN eurjchem-11 123 45 ) ) PUNCT eurjchem-11 123 46     SPACE eurjchem-11 123 47 spectra spectra NOUN eurjchem-11 123 48     SPACE eurjchem-11 123 49 of of ADP eurjchem-11 123 50     SPACE eurjchem-11 123 51 the the DET eurjchem-11 123 52     SPACE eurjchem-11 123 53 unknown unknown ADJ eurjchem-11 123 54     SPACE eurjchem-11 123 55 impurity impurity NOUN eurjchem-11 123 56     SPACE eurjchem-11 123 57 at at ADP eurjchem-11 123 58     SPACE eurjchem-11 123 59 rrt rrt NOUN eurjchem-11 123 60     SPACE eurjchem-11 123 61 1.06 1.06 NUM eurjchem-11 123 62     SPACE eurjchem-11 123 63 in in ADP eurjchem-11 123 64     SPACE eurjchem-11 123 65 thermal thermal ADJ eurjchem-11 123 66     SPACE eurjchem-11 123 67 degradation degradation NOUN eurjchem-11 123 68     SPACE eurjchem-11 123 69 of of ADP eurjchem-11 123 70     SPACE eurjchem-11 123 71 aripiprazole aripiprazole NOUN eurjchem-11 123 72     SPACE eurjchem-11 123 73 tablet tablet NOUN eurjchem-11 123 74     SPACE eurjchem-11 123 75 sample sample NOUN eurjchem-11 123 76 . . PUNCT eurjchem-11 123 77     SPACE eurjchem-11 124 1 26 26 NUM eurjchem-11 124 2     SPACE eurjchem-11 124 3 reddy reddy PROPN eurjchem-11 124 4     SPACE eurjchem-11 124 5 et et PROPN eurjchem-11 124 6     SPACE eurjchem-11 124 7 al al PROPN eurjchem-11 124 8 . . PROPN eurjchem-11 124 9     SPACE eurjchem-11 124 10 / / SYM eurjchem-11 124 11     SPACE eurjchem-11 124 12 european european ADJ eurjchem-11 124 13     SPACE eurjchem-11 124 14 journal journal NOUN eurjchem-11 124 15     SPACE eurjchem-11 124 16 of of ADP eurjchem-11 124 17     SPACE eurjchem-11 124 18 chemistry chemistry NOUN eurjchem-11 124 19     SPACE eurjchem-11 124 20 1 1 NUM eurjchem-11 124 21     SPACE eurjchem-11 124 22 ( ( PUNCT eurjchem-11 124 23 1 1 NUM eurjchem-11 124 24 ) ) PUNCT eurjchem-11 124 25     SPACE eurjchem-11 124 26 ( ( PUNCT eurjchem-11 124 27 2010 2010 NUM eurjchem-11 124 28 ) ) PUNCT eurjchem-11 124 29     SPACE eurjchem-11 124 30 20­27 20­27 NUM eurjchem-11 124 31         SPACE eurjchem-11 124 32 figure figure NOUN eurjchem-11 124 33     SPACE eurjchem-11 124 34 7 7 NUM eurjchem-11 124 35     SPACE eurjchem-11 124 36 shows show VERB eurjchem-11 124 37     SPACE eurjchem-11 124 38 the the DET eurjchem-11 124 39     SPACE eurjchem-11 124 40 ms ms NOUN eurjchem-11 124 41     SPACE eurjchem-11 124 42 and and CCONJ eurjchem-11 124 43     SPACE eurjchem-11 124 44 ms ms PROPN eurjchem-11 124 45 / / SYM eurjchem-11 124 46 ms ms PROPN eurjchem-11 124 47     SPACE eurjchem-11 124 48 spectra spectra NOUN eurjchem-11 124 49     SPACE eurjchem-11 124 50 of of ADP eurjchem-11 124 51     SPACE eurjchem-11 124 52 the the DET eurjchem-11 124 53     SPACE eurjchem-11 124 54 unknown unknown ADJ eurjchem-11 124 55     SPACE eurjchem-11 124 56 impurity impurity NOUN eurjchem-11 124 57     SPACE eurjchem-11 124 58 at at ADP eurjchem-11 124 59     SPACE eurjchem-11 124 60 rrt rrt NOUN eurjchem-11 124 61     SPACE eurjchem-11 124 62 1.14 1.14 NUM eurjchem-11 124 63     SPACE eurjchem-11 124 64 in in ADP eurjchem-11 124 65     SPACE eurjchem-11 124 66 thermal thermal ADJ eurjchem-11 124 67     SPACE eurjchem-11 124 68 degradation degradation NOUN eurjchem-11 124 69     SPACE eurjchem-11 124 70 of of ADP eurjchem-11 124 71     SPACE eurjchem-11 124 72 aripiprazole aripiprazole NOUN eurjchem-11 124 73     SPACE eurjchem-11 124 74 tablet tablet NOUN eurjchem-11 124 75     SPACE eurjchem-11 124 76 sample sample NOUN eurjchem-11 124 77 . . PUNCT eurjchem-11 124 78     SPACE eurjchem-11 125 1 the the DET eurjchem-11 125 2     SPACE eurjchem-11 125 3 unknown unknown ADJ eurjchem-11 125 4     SPACE eurjchem-11 125 5 impurity impurity NOUN eurjchem-11 125 6     SPACE eurjchem-11 125 7 having have VERB eurjchem-11 125 8     SPACE eurjchem-11 125 9 the the DET eurjchem-11 125 10     SPACE eurjchem-11 125 11 molecular molecular ADJ eurjchem-11 125 12     SPACE eurjchem-11 125 13 ion ion NOUN eurjchem-11 125 14     SPACE eurjchem-11 125 15 at at ADP eurjchem-11 125 16     SPACE eurjchem-11 125 17 m m PROPN eurjchem-11 125 18 / / PROPN eurjchem-11 125 19 z z NOUN eurjchem-11 125 20     SPACE eurjchem-11 125 21 218 218 NUM eurjchem-11 125 22     SPACE eurjchem-11 125 23 and and CCONJ eurjchem-11 125 24     SPACE eurjchem-11 125 25 its its PRON eurjchem-11 125 26     SPACE eurjchem-11 125 27 major major ADJ eurjchem-11 125 28     SPACE eurjchem-11 125 29 fragments fragment NOUN eurjchem-11 125 30     SPACE eurjchem-11 125 31 were be AUX eurjchem-11 125 32     SPACE eurjchem-11 125 33 observed observe VERB eurjchem-11 125 34     SPACE eurjchem-11 125 35 at at ADP eurjchem-11 125 36     SPACE eurjchem-11 125 37 m m PROPN eurjchem-11 125 38 / / PROPN eurjchem-11 126 1 z z NOUN eurjchem-11 126 2     SPACE eurjchem-11 126 3 176 176 NUM eurjchem-11 126 4 , , PUNCT eurjchem-11 126 5     SPACE eurjchem-11 126 6 164 164 NUM eurjchem-11 126 7     SPACE eurjchem-11 126 8 and and CCONJ eurjchem-11 126 9     SPACE eurjchem-11 126 10 146 146 NUM eurjchem-11 126 11 . . PUNCT eurjchem-11 126 12     SPACE eurjchem-11 126 13 this this DET eurjchem-11 126 14     SPACE eurjchem-11 126 15 impurity impurity NOUN eurjchem-11 126 16     SPACE eurjchem-11 126 17 was be AUX eurjchem-11 126 18     SPACE eurjchem-11 126 19 found find VERB eurjchem-11 126 20     SPACE eurjchem-11 126 21 in in ADP eurjchem-11 126 22     SPACE eurjchem-11 126 23 the the DET eurjchem-11 126 24     SPACE eurjchem-11 126 25 aripiprazole aripiprazole NOUN eurjchem-11 126 26     SPACE eurjchem-11 126 27 moiety moiety NOUN eurjchem-11 126 28 , , PUNCT eurjchem-11 126 29     SPACE eurjchem-11 126 30 indicates indicate VERB eurjchem-11 126 31     SPACE eurjchem-11 126 32 that that SCONJ eurjchem-11 126 33     SPACE eurjchem-11 126 34 the the DET eurjchem-11 126 35     SPACE eurjchem-11 126 36 moiety moiety NOUN eurjchem-11 126 37     SPACE eurjchem-11 126 38 was be AUX eurjchem-11 126 39     SPACE eurjchem-11 126 40 coming come VERB eurjchem-11 126 41     SPACE eurjchem-11 126 42 from from ADP eurjchem-11 126 43     SPACE eurjchem-11 126 44 the the DET eurjchem-11 126 45     SPACE eurjchem-11 126 46 aripiprazole aripiprazole NOUN eurjchem-11 126 47 . . PUNCT eurjchem-11 126 48     SPACE eurjchem-11 127 1 the the DET eurjchem-11 127 2     SPACE eurjchem-11 127 3 ms ms PROPN eurjchem-11 127 4     SPACE eurjchem-11 127 5 spectrum spectrum NOUN eurjchem-11 127 6     SPACE eurjchem-11 127 7 of of ADP eurjchem-11 127 8     SPACE eurjchem-11 127 9 this this DET eurjchem-11 127 10     SPACE eurjchem-11 127 11 unknown unknown ADJ eurjchem-11 127 12     SPACE eurjchem-11 127 13 impurity impurity NOUN eurjchem-11 127 14     SPACE eurjchem-11 127 15 suggests suggest VERB eurjchem-11 127 16     SPACE eurjchem-11 127 17 that that SCONJ eurjchem-11 127 18     SPACE eurjchem-11 127 19 it it PRON eurjchem-11 127 20     SPACE eurjchem-11 127 21 did do AUX eurjchem-11 127 22     SPACE eurjchem-11 127 23 not not PART eurjchem-11 127 24     SPACE eurjchem-11 127 25 have have VERB eurjchem-11 127 26     SPACE eurjchem-11 127 27 the the DET eurjchem-11 127 28     SPACE eurjchem-11 127 29 chloro chloro NOUN eurjchem-11 127 30     SPACE eurjchem-11 127 31 moiety moiety NOUN eurjchem-11 127 32 . . PUNCT eurjchem-11 127 33     SPACE eurjchem-11 127 34 the the DET eurjchem-11 127 35     SPACE eurjchem-11 127 36 fragmentation fragmentation NOUN eurjchem-11 127 37     SPACE eurjchem-11 127 38 pattern pattern NOUN eurjchem-11 127 39     SPACE eurjchem-11 127 40 and and CCONJ eurjchem-11 127 41     SPACE eurjchem-11 127 42 the the DET eurjchem-11 127 43     SPACE eurjchem-11 127 44 possible possible ADJ eurjchem-11 127 45     SPACE eurjchem-11 127 46 structure structure NOUN eurjchem-11 127 47     SPACE eurjchem-11 127 48 of of ADP eurjchem-11 127 49     SPACE eurjchem-11 127 50 this this DET eurjchem-11 127 51     SPACE eurjchem-11 127 52 unknown unknown ADJ eurjchem-11 127 53     SPACE eurjchem-11 127 54 impurity impurity NOUN eurjchem-11 127 55     SPACE eurjchem-11 127 56 were be AUX eurjchem-11 127 57     SPACE eurjchem-11 127 58 presented present VERB eurjchem-11 127 59     SPACE eurjchem-11 127 60 in in ADP eurjchem-11 127 61     SPACE eurjchem-11 127 62 scheme scheme NOUN eurjchem-11 127 63     SPACE eurjchem-11 127 64 4 4 NUM eurjchem-11 127 65 . . PUNCT eurjchem-11 127 66           SPACE eurjchem-11 127 67 ( ( PUNCT eurjchem-11 127 68 a a X eurjchem-11 127 69 ) ) PUNCT eurjchem-11 127 70                   SPACE eurjchem-11 127 71 ( ( PUNCT eurjchem-11 127 72 b b NOUN eurjchem-11 127 73 ) ) PUNCT eurjchem-11 127 74         SPACE eurjchem-11 127 75 figure figure NOUN eurjchem-11 127 76     SPACE eurjchem-11 127 77 7 7 NUM eurjchem-11 127 78 . . PUNCT eurjchem-11 127 79     SPACE eurjchem-11 127 80 ms ms PROPN eurjchem-11 127 81     SPACE eurjchem-11 127 82 ( ( PUNCT eurjchem-11 127 83 a a NOUN eurjchem-11 127 84 ) ) PUNCT eurjchem-11 127 85     SPACE eurjchem-11 127 86 and and CCONJ eurjchem-11 127 87     SPACE eurjchem-11 127 88 ms ms PROPN eurjchem-11 127 89 / / SYM eurjchem-11 127 90 ms ms NOUN eurjchem-11 127 91     SPACE eurjchem-11 127 92 ( ( PUNCT eurjchem-11 127 93 b b NOUN eurjchem-11 127 94 ) ) PUNCT eurjchem-11 127 95     SPACE eurjchem-11 127 96 spectra spectra NOUN eurjchem-11 127 97     SPACE eurjchem-11 127 98 of of ADP eurjchem-11 127 99     SPACE eurjchem-11 127 100 the the DET eurjchem-11 127 101     SPACE eurjchem-11 127 102 unknown unknown ADJ eurjchem-11 127 103     SPACE eurjchem-11 127 104 impurity impurity NOUN eurjchem-11 127 105     SPACE eurjchem-11 127 106 at at ADP eurjchem-11 127 107     SPACE eurjchem-11 127 108 rrt rrt NOUN eurjchem-11 127 109     SPACE eurjchem-11 127 110 1.14 1.14 NUM eurjchem-11 127 111     SPACE eurjchem-11 127 112 in in ADP eurjchem-11 127 113     SPACE eurjchem-11 127 114 thermal thermal ADJ eurjchem-11 127 115     SPACE eurjchem-11 127 116 degradation degradation NOUN eurjchem-11 127 117     SPACE eurjchem-11 127 118 of of ADP eurjchem-11 127 119     SPACE eurjchem-11 127 120 aripiprazole aripiprazole NOUN eurjchem-11 127 121     SPACE eurjchem-11 127 122 tablet tablet NOUN eurjchem-11 127 123     SPACE eurjchem-11 127 124 sample sample NOUN eurjchem-11 127 125 . . PUNCT eurjchem-11 127 126                 SPACE eurjchem-11 128 1 scheme scheme NOUN eurjchem-11 128 2     SPACE eurjchem-11 128 3 3 3 NUM eurjchem-11 128 4 . . PUNCT eurjchem-11 129 1 fragmentation fragmentation NOUN eurjchem-11 129 2     SPACE eurjchem-11 129 3 of of ADP eurjchem-11 129 4     SPACE eurjchem-11 129 5 the the DET eurjchem-11 129 6     SPACE eurjchem-11 129 7 unknown unknown ADJ eurjchem-11 129 8     SPACE eurjchem-11 129 9 impurity impurity NOUN eurjchem-11 129 10     SPACE eurjchem-11 129 11 at at ADP eurjchem-11 129 12     SPACE eurjchem-11 129 13 rrt rrt NOUN eurjchem-11 129 14     SPACE eurjchem-11 129 15 1.06 1.06 NUM eurjchem-11 129 16 . . PUNCT eurjchem-11 129 17     SPACE eurjchem-11 130 1 4 4 NUM eurjchem-11 130 2 . . PUNCT eurjchem-11 130 3     SPACE eurjchem-11 130 4 conclusions conclusion NOUN eurjchem-11 130 5           SPACE eurjchem-11 130 6 this this DET eurjchem-11 130 7     SPACE eurjchem-11 130 8 investigation investigation NOUN eurjchem-11 130 9     SPACE eurjchem-11 130 10 demonstrated demonstrate VERB eurjchem-11 130 11     SPACE eurjchem-11 130 12 the the DET eurjchem-11 130 13     SPACE eurjchem-11 130 14 unambiguous unambiguous ADJ eurjchem-11 130 15     SPACE eurjchem-11 130 16 identification identification NOUN eurjchem-11 130 17     SPACE eurjchem-11 130 18 of of ADP eurjchem-11 130 19     SPACE eurjchem-11 130 20 the the DET eurjchem-11 130 21     SPACE eurjchem-11 130 22 unknown unknown ADJ eurjchem-11 130 23     SPACE eurjchem-11 130 24 impurities impurity NOUN eurjchem-11 130 25     SPACE eurjchem-11 130 26 formed form VERB eurjchem-11 130 27     SPACE eurjchem-11 130 28 during during ADP eurjchem-11 130 29     SPACE eurjchem-11 130 30 degradation degradation NOUN eurjchem-11 130 31     SPACE eurjchem-11 130 32 studies study NOUN eurjchem-11 130 33     SPACE eurjchem-11 130 34 of of ADP eurjchem-11 130 35     SPACE eurjchem-11 130 36 aripiprazole aripiprazole NOUN eurjchem-11 130 37     SPACE eurjchem-11 130 38 tablets tablet NOUN eurjchem-11 130 39     SPACE eurjchem-11 130 40 and and CCONJ eurjchem-11 130 41     SPACE eurjchem-11 130 42 was be AUX eurjchem-11 130 43     SPACE eurjchem-11 130 44 achieved achieve VERB eurjchem-11 130 45     SPACE eurjchem-11 130 46 by by ADP eurjchem-11 130 47     SPACE eurjchem-11 130 48 lc lc PROPN eurjchem-11 130 49 – – PUNCT eurjchem-11 130 50 qtof‐ms qtof‐ms NUM eurjchem-11 130 51 . . PUNCT eurjchem-11 130 52     SPACE eurjchem-11 130 53 aripiprazole aripiprazole PROPN eurjchem-11 130 54     SPACE eurjchem-11 130 55 tablet tablet NOUN eurjchem-11 130 56     SPACE eurjchem-11 130 57 formulation formulation NOUN eurjchem-11 130 58     SPACE eurjchem-11 130 59 undergoes undergo VERB eurjchem-11 130 60     SPACE eurjchem-11 130 61 severe severe ADJ eurjchem-11 130 62     SPACE eurjchem-11 130 63 degradation degradation NOUN eurjchem-11 130 64     SPACE eurjchem-11 130 65 in in ADP eurjchem-11 130 66     SPACE eurjchem-11 130 67 thermal thermal ADJ eurjchem-11 130 68     SPACE eurjchem-11 130 69 degradation degradation NOUN eurjchem-11 130 70     SPACE eurjchem-11 130 71 condition condition NOUN eurjchem-11 130 72     SPACE eurjchem-11 130 73 of of ADP eurjchem-11 130 74     SPACE eurjchem-11 130 75 105 105 NUM eurjchem-11 130 76     SPACE eurjchem-11 130 77 ° ° NOUN eurjchem-11 130 78 c c NOUN eurjchem-11 130 79     SPACE eurjchem-11 130 80 for for ADP eurjchem-11 130 81     SPACE eurjchem-11 130 82 3 3 NUM eurjchem-11 130 83     SPACE eurjchem-11 130 84 days day NOUN eurjchem-11 130 85 . . PUNCT eurjchem-11 130 86     SPACE eurjchem-11 131 1 three three NUM eurjchem-11 131 2     SPACE eurjchem-11 131 3 unknown unknown ADJ eurjchem-11 131 4     SPACE eurjchem-11 131 5 impurities impurity NOUN eurjchem-11 131 6     SPACE eurjchem-11 131 7 at at ADP eurjchem-11 131 8     SPACE eurjchem-11 131 9 rrts rrt NOUN eurjchem-11 131 10     SPACE eurjchem-11 131 11 of of ADP eurjchem-11 131 12     SPACE eurjchem-11 131 13 0.45 0.45 NUM eurjchem-11 131 14 , , PUNCT eurjchem-11 131 15     SPACE eurjchem-11 131 16 1.06 1.06 NUM eurjchem-11 131 17     SPACE eurjchem-11 131 18 and and CCONJ eurjchem-11 131 19     SPACE eurjchem-11 131 20 1.1.4 1.1.4 NUM eurjchem-11 131 21     SPACE eurjchem-11 131 22 were be AUX eurjchem-11 131 23     SPACE eurjchem-11 131 24 detected detect VERB eurjchem-11 131 25     SPACE eurjchem-11 131 26 during during ADP eurjchem-11 131 27     SPACE eurjchem-11 131 28 the the DET eurjchem-11 131 29     SPACE eurjchem-11 131 30 degradation degradation NOUN eurjchem-11 131 31     SPACE eurjchem-11 131 32 studies study NOUN eurjchem-11 131 33 . . PUNCT eurjchem-11 131 34     SPACE eurjchem-11 131 35 from from ADP eurjchem-11 131 36     SPACE eurjchem-11 131 37 qtof‐ms qtof‐ms NOUN eurjchem-11 131 38     SPACE eurjchem-11 131 39 and and CCONJ eurjchem-11 131 40     SPACE eurjchem-11 131 41 ms ms PROPN eurjchem-11 131 42 / / SYM eurjchem-11 131 43 ms ms PROPN eurjchem-11 131 44     SPACE eurjchem-11 131 45 fragmentation fragmentation NOUN eurjchem-11 131 46     SPACE eurjchem-11 131 47 pattern pattern NOUN eurjchem-11 131 48 , , PUNCT eurjchem-11 131 49     SPACE eurjchem-11 131 50 the the DET eurjchem-11 131 51     SPACE eurjchem-11 131 52 structures structure NOUN eurjchem-11 131 53     SPACE eurjchem-11 131 54 of of ADP eurjchem-11 131 55     SPACE eurjchem-11 131 56 the the DET eurjchem-11 131 57     SPACE eurjchem-11 131 58 unknown unknown ADJ eurjchem-11 131 59     SPACE eurjchem-11 131 60 impurities impurity NOUN eurjchem-11 131 61     SPACE eurjchem-11 131 62 in in ADP eurjchem-11 131 63     SPACE eurjchem-11 131 64 aripiprazole aripiprazole NOUN eurjchem-11 131 65     SPACE eurjchem-11 131 66 drug drug NOUN eurjchem-11 131 67     SPACE eurjchem-11 131 68 product product NOUN eurjchem-11 131 69     SPACE eurjchem-11 131 70 were be AUX eurjchem-11 131 71     SPACE eurjchem-11 131 72 elucidated elucidated ADJ eurjchem-11 131 73     SPACE eurjchem-11 131 74 and and CCONJ eurjchem-11 131 75     SPACE eurjchem-11 131 76 named name VERB eurjchem-11 131 77     SPACE eurjchem-11 131 78 as as ADP eurjchem-11 131 79     SPACE eurjchem-11 131 80 1‐but‐3‐enyl‐4‐(2,3‐dichloro‐phenyl)‐ 1‐but‐3‐enyl‐4‐(2,3‐dichloro‐phenyl)‐ PROPN eurjchem-11 131 81 piperazine piperazine NOUN eurjchem-11 131 82     SPACE eurjchem-11 131 83 ( ( PUNCT eurjchem-11 131 84 0.45 0.45 NUM eurjchem-11 131 85     SPACE eurjchem-11 131 86 rrt rrt NOUN eurjchem-11 131 87 ) ) PUNCT eurjchem-11 131 88 , , PUNCT eurjchem-11 131 89     SPACE eurjchem-11 131 90 aripiprazole aripiprazole NOUN eurjchem-11 131 91     SPACE eurjchem-11 131 92 n‐oxide n‐oxide ADV eurjchem-11 131 93     SPACE eurjchem-11 131 94 ( ( PUNCT eurjchem-11 131 95 1.06 1.06 NUM eurjchem-11 131 96     SPACE eurjchem-11 131 97 rrt rrt NOUN eurjchem-11 131 98 ) ) PUNCT eurjchem-11 131 99     SPACE eurjchem-11 131 100 and and CCONJ eurjchem-11 131 101     SPACE eurjchem-11 131 102 7‐ 7‐ NUM eurjchem-11 131 103 but‐3‐enyloxy‐3,4‐dihydro‐1h‐quinolin‐2‐one but‐3‐enyloxy‐3,4‐dihydro‐1h‐quinolin‐2‐one NOUN eurjchem-11 131 104     SPACE eurjchem-11 131 105 ( ( PUNCT eurjchem-11 131 106 1.14 1.14 NUM eurjchem-11 131 107     SPACE eurjchem-11 131 108 rrt rrt NOUN eurjchem-11 131 109 ) ) PUNCT eurjchem-11 131 110 . . PUNCT eurjchem-11 131 111     SPACE eurjchem-11 132 1 finally finally ADV eurjchem-11 132 2 , , PUNCT eurjchem-11 132 3     SPACE eurjchem-11 132 4 qtof qtof PROPN eurjchem-11 132 5     SPACE eurjchem-11 132 6 mass mass PROPN eurjchem-11 132 7     SPACE eurjchem-11 132 8 study study NOUN eurjchem-11 132 9     SPACE eurjchem-11 132 10 is be AUX eurjchem-11 132 11     SPACE eurjchem-11 132 12 a a DET eurjchem-11 132 13     SPACE eurjchem-11 132 14 useful useful ADJ eurjchem-11 132 15     SPACE eurjchem-11 132 16 technique technique NOUN eurjchem-11 132 17     SPACE eurjchem-11 132 18 for for ADP eurjchem-11 132 19     SPACE eurjchem-11 132 20 structure structure NOUN eurjchem-11 132 21     SPACE eurjchem-11 132 22 elucidation elucidation NOUN eurjchem-11 132 23     SPACE eurjchem-11 132 24 of of ADP eurjchem-11 132 25     SPACE eurjchem-11 132 26 the the DET eurjchem-11 132 27     SPACE eurjchem-11 132 28 unknown unknown ADJ eurjchem-11 132 29     SPACE eurjchem-11 132 30 impurities impurity NOUN eurjchem-11 132 31     SPACE eurjchem-11 132 32 in in ADP eurjchem-11 132 33     SPACE eurjchem-11 132 34 the the DET eurjchem-11 132 35     SPACE eurjchem-11 132 36 aripiprazole aripiprazole NOUN eurjchem-11 132 37     SPACE eurjchem-11 132 38 tablets tablet NOUN eurjchem-11 132 39 . . PUNCT eurjchem-11 132 40           SPACE eurjchem-11 133 1 n n PRON eurjchem-11 133 2 h2 h2 NOUN eurjchem-11 133 3 + + CCONJ eurjchem-11 133 4 o o NOUN eurjchem-11 133 5 ch2o ch2o VERB eurjchem-11 133 6 o o NOUN eurjchem-11 133 7 ch2 ch2 NOUN eurjchem-11 133 8 + + CCONJ eurjchem-11 133 9 o o PROPN eurjchem-11 133 10 n n PRON eurjchem-11 133 11 h h NOUN eurjchem-11 133 12 oh2 oh2 PROPN eurjchem-11 134 1 + + NOUN eurjchem-11 134 2 o o PROPN eurjchem-11 134 3 n n DET eurjchem-11 134 4 h h NOUN eurjchem-11 134 5 c+ c+ VERB eurjchem-11 134 6 o o NOUN eurjchem-11 135 1 n n CCONJ eurjchem-11 135 2 h h NOUN eurjchem-11 135 3 h2n h2n PROPN eurjchem-11 136 1 o o X eurjchem-11 136 2 ch2 ch2 PROPN eurjchem-11 136 3 + + CCONJ eurjchem-11 136 4 h2n h2n PROPN eurjchem-11 136 5 oh2 oh2 NOUN eurjchem-11 136 6 + + PROPN eurjchem-11 136 7 ch3 ch3 PROPN eurjchem-11 136 8 ch2 ch2 PROPN eurjchem-11 136 9 ch3 ch3 PROPN eurjchem-11 136 10 ch2 ch2 PROPN eurjchem-11 136 11 ho ho PROPN eurjchem-11 136 12 ch2 ch2 PROPN eurjchem-11 136 13 m m PROPN eurjchem-11 136 14 / / SYM eurjchem-11 136 15 z z PROPN eurjchem-11 136 16 218.1181 218.1181 NUM eurjchem-11 136 17 m m PROPN eurjchem-11 136 18 / / SYM eurjchem-11 136 19 z z PROPN eurjchem-11 136 20 176.0711 176.0711 NUM eurjchem-11 136 21 m m NOUN eurjchem-11 136 22 / / SYM eurjchem-11 136 23 z z PROPN eurjchem-11 136 24 164.0711 164.0711 NUM eurjchem-11 136 25 m m NOUN eurjchem-11 136 26 / / SYM eurjchem-11 136 27 z z PROPN eurjchem-11 136 28 146.0606 146.0606 NUM eurjchem-11 136 29 m m NOUN eurjchem-11 136 30 / / SYM eurjchem-11 136 31 z z PROPN eurjchem-11 136 32 122.0606 122.0606 NUM eurjchem-11 136 33 m m NOUN eurjchem-11 136 34 / / SYM eurjchem-11 136 35 z z PROPN eurjchem-11 136 36 10.0606 10.0606 NUM eurjchem-11 136 37 n n PRON eurjchem-11 136 38 h2 h2 NOUN eurjchem-11 137 1 + + CCONJ eurjchem-11 137 2 o o NOUN eurjchem-11 137 3 ch2o ch2o NOUN eurjchem-11 137 4 n n PRON eurjchem-11 137 5 h2 h2 NOUN eurjchem-11 137 6 + + CCONJ eurjchem-11 137 7 o o X eurjchem-11 137 8 ch2o ch2o NOUN eurjchem-11 137 9         SPACE eurjchem-11 137 10 scheme scheme NOUN eurjchem-11 137 11     SPACE eurjchem-11 137 12 4 4 NUM eurjchem-11 137 13 . . PUNCT eurjchem-11 138 1 fragmentation fragmentation NOUN eurjchem-11 138 2     SPACE eurjchem-11 138 3 of of ADP eurjchem-11 138 4     SPACE eurjchem-11 138 5 the the DET eurjchem-11 138 6     SPACE eurjchem-11 138 7 unknown unknown ADJ eurjchem-11 138 8     SPACE eurjchem-11 138 9 impurity impurity NOUN eurjchem-11 138 10     SPACE eurjchem-11 138 11 at at ADP eurjchem-11 138 12     SPACE eurjchem-11 138 13 rrt rrt NOUN eurjchem-11 138 14     SPACE eurjchem-11 138 15 1.14 1.14 NUM eurjchem-11 138 16 . . PUNCT eurjchem-11 138 17         SPACE eurjchem-11 139 1 acknowledgement acknowledgement NOUN eurjchem-11 139 2         SPACE eurjchem-11 139 3 the the DET eurjchem-11 139 4     SPACE eurjchem-11 139 5 authors author NOUN eurjchem-11 139 6     SPACE eurjchem-11 139 7 wish wish VERB eurjchem-11 139 8     SPACE eurjchem-11 139 9 to to PART eurjchem-11 139 10     SPACE eurjchem-11 139 11 thank thank VERB eurjchem-11 139 12     SPACE eurjchem-11 139 13 jubilant jubilant ADJ eurjchem-11 139 14     SPACE eurjchem-11 139 15 organosys organosy NOUN eurjchem-11 139 16     SPACE eurjchem-11 139 17 ( ( PUNCT eurjchem-11 139 18 noida noida PROPN eurjchem-11 139 19 , , PUNCT eurjchem-11 139 20     SPACE eurjchem-11 139 21 india india PROPN eurjchem-11 139 22 ) ) PUNCT eurjchem-11 139 23 , , PUNCT eurjchem-11 139 24     SPACE eurjchem-11 139 25 mrs mrs PROPN eurjchem-11 139 26 . . PROPN eurjchem-11 139 27     SPACE eurjchem-11 139 28 poonam poonam PROPN eurjchem-11 139 29     SPACE eurjchem-11 139 30 kumar kumar PROPN eurjchem-11 139 31     SPACE eurjchem-11 139 32 and and CCONJ eurjchem-11 139 33     SPACE eurjchem-11 139 34 h. h. PROPN eurjchem-11 139 35     SPACE eurjchem-11 139 36 d. d. PROPN eurjchem-11 139 37     SPACE eurjchem-11 139 38 gauttam gauttam NOUN eurjchem-11 139 39     SPACE eurjchem-11 139 40 for for ADP eurjchem-11 139 41     SPACE eurjchem-11 139 42 their their PRON eurjchem-11 139 43     SPACE eurjchem-11 139 44 support support NOUN eurjchem-11 139 45     SPACE eurjchem-11 139 46 to to PART eurjchem-11 139 47     SPACE eurjchem-11 139 48 provide provide VERB eurjchem-11 139 49     SPACE eurjchem-11 139 50 the the DET eurjchem-11 139 51     SPACE eurjchem-11 139 52 samples sample NOUN eurjchem-11 139 53     SPACE eurjchem-11 139 54 and and CCONJ eurjchem-11 139 55     SPACE eurjchem-11 139 56 encouragement encouragement NOUN eurjchem-11 139 57 . . PUNCT eurjchem-11 139 58           SPACE eurjchem-11 140 1 references reference NOUN eurjchem-11 140 2           SPACE eurjchem-11 140 3 [ [ X eurjchem-11 140 4 1 1 NUM eurjchem-11 140 5 ] ] PUNCT eurjchem-11 140 6 . . PUNCT eurjchem-11 141 1 tamminga tamminga PROPN eurjchem-11 141 2 , , PUNCT eurjchem-11 141 3     SPACE eurjchem-11 141 4 c. c. PROPN eurjchem-11 141 5     SPACE eurjchem-11 141 6 a. a. PROPN eurjchem-11 141 7     SPACE eurjchem-11 141 8 j. j. PROPN eurjchem-11 141 9     SPACE eurjchem-11 141 10 neural neural ADJ eurjchem-11 141 11     SPACE eurjchem-11 141 12 transm transm PROPN eurjchem-11 141 13 . . PUNCT eurjchem-11 141 14     SPACE eurjchem-11 141 15 2002 2002 NUM eurjchem-11 141 16 , , PUNCT eurjchem-11 141 17     SPACE eurjchem-11 141 18 109 109 NUM eurjchem-11 141 19 , , PUNCT eurjchem-11 141 20     SPACE eurjchem-11 141 21 411‐420 411‐420 PROPN eurjchem-11 141 22 . . PUNCT eurjchem-11 141 23     SPACE eurjchem-11 142 1 [ [ X eurjchem-11 142 2 2 2 NUM eurjchem-11 142 3 ] ] PUNCT eurjchem-11 142 4 . . PUNCT eurjchem-11 142 5 burris burris PROPN eurjchem-11 142 6 , , PUNCT eurjchem-11 142 7     SPACE eurjchem-11 142 8 k. k. PROPN eurjchem-11 142 9     SPACE eurjchem-11 142 10 d. d. PROPN eurjchem-11 142 11 ; ; PUNCT eurjchem-11 142 12     SPACE eurjchem-11 142 13 molski molski ADJ eurjchem-11 142 14 , , PUNCT eurjchem-11 142 15     SPACE eurjchem-11 142 16 t. t. PROPN eurjchem-11 142 17     SPACE eurjchem-11 142 18 f. f. PROPN eurjchem-11 142 19 ; ; PUNCT eurjchem-11 142 20     SPACE eurjchem-11 142 21 xu xu PROPN eurjchem-11 142 22 , , PUNCT eurjchem-11 142 23     SPACE eurjchem-11 142 24 c. c. NOUN eurjchem-11 142 25 ; ; PUNCT eurjchem-11 142 26     SPACE eurjchem-11 142 27 ryan ryan NOUN eurjchem-11 142 28 , , PUNCT eurjchem-11 142 29     SPACE eurjchem-11 142 30 e. e. PROPN eurjchem-11 142 31 ; ; PUNCT eurjchem-11 142 32     SPACE eurjchem-11 142 33 tottori tottori NOUN eurjchem-11 142 34 , , PUNCT eurjchem-11 142 35     SPACE eurjchem-11 142 36 k. k. PROPN eurjchem-11 142 37 ; ; PUNCT eurjchem-11 142 38     SPACE eurjchem-11 142 39 kikuchi kikuchi PROPN eurjchem-11 142 40 , , PUNCT eurjchem-11 142 41     SPACE eurjchem-11 142 42 t. t. PROPN eurjchem-11 142 43 ; ; PUNCT eurjchem-11 142 44     SPACE eurjchem-11 142 45 yocca yocca ADJ eurjchem-11 142 46 , , PUNCT eurjchem-11 142 47     SPACE eurjchem-11 142 48 f. f. PROPN eurjchem-11 142 49     SPACE eurjchem-11 142 50 d. d. PROPN eurjchem-11 142 51 ; ; PUNCT eurjchem-11 142 52     SPACE eurjchem-11 142 53 molinoff molinoff NOUN eurjchem-11 142 54 , , PUNCT eurjchem-11 142 55     SPACE eurjchem-11 142 56 p. p. NOUN eurjchem-11 142 57     SPACE eurjchem-11 142 58 b. b. PROPN eurjchem-11 142 59     SPACE eurjchem-11 142 60 j. j. PROPN eurjchem-11 142 61     SPACE eurjchem-11 142 62 pharmacol pharmacol PROPN eurjchem-11 142 63 . . PUNCT eurjchem-11 142 64     SPACE eurjchem-11 142 65 exp exp NOUN eurjchem-11 142 66 . . PUNCT eurjchem-11 142 67     SPACE eurjchem-11 143 1 ther ther ADV eurjchem-11 143 2 . . PUNCT eurjchem-11 143 3     SPACE eurjchem-11 144 1 2002 2002 NUM eurjchem-11 144 2 , , PUNCT eurjchem-11 144 3     SPACE eurjchem-11 144 4 302 302 NUM eurjchem-11 144 5 , , PUNCT eurjchem-11 144 6     SPACE eurjchem-11 144 7 381‐ 381‐ NUM eurjchem-11 144 8 389 389 NUM eurjchem-11 144 9 . . PUNCT eurjchem-11 144 10     SPACE eurjchem-11 145 1 [ [ X eurjchem-11 145 2 3 3 NUM eurjchem-11 145 3 ] ] PUNCT eurjchem-11 145 4 . . PUNCT eurjchem-11 146 1 jordan jordan PROPN eurjchem-11 146 2 , , PUNCT eurjchem-11 146 3     SPACE eurjchem-11 146 4 s. s. PROPN eurjchem-11 146 5 ; ; PUNCT eurjchem-11 146 6     SPACE eurjchem-11 146 7 koprivica koprivica PROPN eurjchem-11 146 8 , , PUNCT eurjchem-11 146 9     SPACE eurjchem-11 146 10 v. v. ADV eurjchem-11 146 11 ; ; PUNCT eurjchem-11 146 12     SPACE eurjchem-11 146 13 chen chen PROPN eurjchem-11 146 14 , , PUNCT eurjchem-11 146 15     SPACE eurjchem-11 146 16 r. r. PROPN eurjchem-11 146 17 ; ; PUNCT eurjchem-11 146 18     SPACE eurjchem-11 146 19 tottori tottori NOUN eurjchem-11 146 20 , , PUNCT eurjchem-11 146 21     SPACE eurjchem-11 146 22 k. k. PROPN eurjchem-11 146 23 ; ; PUNCT eurjchem-11 146 24     SPACE eurjchem-11 146 25 kikuchi kikuchi PROPN eurjchem-11 146 26 , , PUNCT eurjchem-11 146 27     SPACE eurjchem-11 146 28 t. t. PROPN eurjchem-11 146 29 ; ; PUNCT eurjchem-11 146 30     SPACE eurjchem-11 146 31 altar altar NOUN eurjchem-11 146 32 , , PUNCT eurjchem-11 146 33     SPACE eurjchem-11 146 34 c.a c.a PROPN eurjchem-11 146 35 . . PROPN eurjchem-11 146 36     SPACE eurjchem-11 146 37 eur eur PROPN eurjchem-11 146 38 . . PUNCT eurjchem-11 146 39     SPACE eurjchem-11 146 40 j. j. PROPN eurjchem-11 146 41     SPACE eurjchem-11 146 42 pharmacol pharmacol PROPN eurjchem-11 146 43 . . PUNCT eurjchem-11 146 44     SPACE eurjchem-11 146 45 2002 2002 NUM eurjchem-11 146 46 , , PUNCT eurjchem-11 146 47     SPACE eurjchem-11 146 48 441 441 NUM eurjchem-11 146 49 , , PUNCT eurjchem-11 146 50     SPACE eurjchem-11 146 51 137‐140 137‐140 NUM eurjchem-11 146 52 . . PUNCT eurjchem-11 146 53     SPACE eurjchem-11 147 1 [ [ X eurjchem-11 147 2 4 4 NUM eurjchem-11 147 3 ] ] PUNCT eurjchem-11 147 4 . . PUNCT eurjchem-11 148 1 hirose hirose PROPN eurjchem-11 148 2 , , PUNCT eurjchem-11 148 3     SPACE eurjchem-11 148 4 t. t. PROPN eurjchem-11 148 5 ; ; PUNCT eurjchem-11 148 6     SPACE eurjchem-11 148 7 uwahodo uwahodo NOUN eurjchem-11 148 8 , , PUNCT eurjchem-11 148 9     SPACE eurjchem-11 148 10 y. y. NOUN eurjchem-11 148 11 ; ; PUNCT eurjchem-11 148 12     SPACE eurjchem-11 148 13 yamada yamada PROPN eurjchem-11 148 14 , , PUNCT eurjchem-11 148 15     SPACE eurjchem-11 148 16 s. s. PROPN eurjchem-11 148 17 ; ; PUNCT eurjchem-11 148 18     SPACE eurjchem-11 148 19 miwa miwa PROPN eurjchem-11 148 20 , , PUNCT eurjchem-11 148 21     SPACE eurjchem-11 148 22 t. t. PROPN eurjchem-11 148 23 ; ; PUNCT eurjchem-11 148 24     SPACE eurjchem-11 148 25 kikuchi kikuchi PROPN eurjchem-11 148 26 , , PUNCT eurjchem-11 148 27     SPACE eurjchem-11 148 28 t. t. PROPN eurjchem-11 148 29 ; ; PUNCT eurjchem-11 148 30     SPACE eurjchem-11 148 31 kitagawa kitagawa PROPN eurjchem-11 148 32 , , PUNCT eurjchem-11 148 33     SPACE eurjchem-11 148 34 h. h. PROPN eurjchem-11 148 35 ; ; PUNCT eurjchem-11 148 36     SPACE eurjchem-11 148 37 burris burris PROPN eurjchem-11 148 38 , , PUNCT eurjchem-11 148 39     SPACE eurjchem-11 148 40 k. k. PROPN eurjchem-11 148 41     SPACE eurjchem-11 148 42 d. d. PROPN eurjchem-11 148 43 ; ; PUNCT eurjchem-11 148 44     SPACE eurjchem-11 148 45 altar altar NOUN eurjchem-11 148 46 , , PUNCT eurjchem-11 148 47     SPACE eurjchem-11 148 48 c. c. PROPN eurjchem-11 148 49     SPACE eurjchem-11 148 50 a. a. NOUN eurjchem-11 148 51 ; ; PUNCT eurjchem-11 148 52     SPACE eurjchem-11 148 53 nabeshima nabeshima PROPN eurjchem-11 148 54 , , PUNCT eurjchem-11 148 55     SPACE eurjchem-11 148 56 t. t. PROPN eurjchem-11 148 57     SPACE eurjchem-11 148 58 j. j. PROPN eurjchem-11 148 59     SPACE eurjchem-11 148 60 psychopharmacol psychopharmacol PROPN eurjchem-11 148 61 . . PUNCT eurjchem-11 148 62     SPACE eurjchem-11 148 63 2004 2004 NUM eurjchem-11 148 64 , , PUNCT eurjchem-11 148 65     SPACE eurjchem-11 148 66 18 18 NUM eurjchem-11 148 67 , , PUNCT eurjchem-11 148 68     SPACE eurjchem-11 148 69 375‐383 375‐383 NOUN eurjchem-11 148 70 . . PUNCT eurjchem-11 148 71     SPACE eurjchem-11 149 1 [ [ X eurjchem-11 149 2 5 5 NUM eurjchem-11 149 3 ] ] PUNCT eurjchem-11 149 4 . . PUNCT eurjchem-11 150 1 kane kane PROPN eurjchem-11 150 2 , , PUNCT eurjchem-11 150 3     SPACE eurjchem-11 150 4 j. j. PROPN eurjchem-11 150 5     SPACE eurjchem-11 150 6 m. m. NOUN eurjchem-11 150 7 ; ; PUNCT eurjchem-11 150 8     SPACE eurjchem-11 150 9 carson carson PROPN eurjchem-11 150 10 , , PUNCT eurjchem-11 150 11     SPACE eurjchem-11 150 12 w. w. PROPN eurjchem-11 150 13     SPACE eurjchem-11 150 14 h. h. PROPN eurjchem-11 150 15 ; ; PUNCT eurjchem-11 150 16     SPACE eurjchem-11 150 17 saha saha NOUN eurjchem-11 150 18 , , PUNCT eurjchem-11 150 19     SPACE eurjchem-11 150 20 a. a. NOUN eurjchem-11 150 21     SPACE eurjchem-11 150 22 r. r. PROPN eurjchem-11 150 23 ; ; PUNCT eurjchem-11 150 24     SPACE eurjchem-11 150 25 mcquade mcquade PROPN eurjchem-11 150 26 , , PUNCT eurjchem-11 150 27     SPACE eurjchem-11 150 28 r. r. PROPN eurjchem-11 150 29     SPACE eurjchem-11 150 30 d. d. PROPN eurjchem-11 150 31 ; ; PUNCT eurjchem-11 150 32     SPACE eurjchem-11 150 33 ingenito ingenito ADJ eurjchem-11 150 34 , , PUNCT eurjchem-11 150 35     SPACE eurjchem-11 150 36 g. g. NOUN eurjchem-11 150 37     SPACE eurjchem-11 150 38 g. g. PROPN eurjchem-11 150 39 ; ; PUNCT eurjchem-11 150 40     SPACE eurjchem-11 150 41 zimbroff zimbroff NOUN eurjchem-11 150 42 , , PUNCT eurjchem-11 150 43     SPACE eurjchem-11 150 44 d. d. PROPN eurjchem-11 150 45     SPACE eurjchem-11 150 46 l. l. PROPN eurjchem-11 150 47 ; ; PUNCT eurjchem-11 150 48     SPACE eurjchem-11 150 49 ali ali PROPN eurjchem-11 150 50 , , PUNCT eurjchem-11 150 51     SPACE eurjchem-11 150 52 m. m. NOUN eurjchem-11 150 53     SPACE eurjchem-11 150 54 w. w. PROPN eurjchem-11 150 55     SPACE eurjchem-11 150 56 j. j. PROPN eurjchem-11 150 57     SPACE eurjchem-11 150 58 clin clin PROPN eurjchem-11 150 59 . . PUNCT eurjchem-11 150 60     SPACE eurjchem-11 150 61 psychiatry psychiatry NOUN eurjchem-11 150 62     SPACE eurjchem-11 150 63 2002 2002 NUM eurjchem-11 150 64 , , PUNCT eurjchem-11 150 65     SPACE eurjchem-11 150 66 63 63 NUM eurjchem-11 150 67 , , PUNCT eurjchem-11 150 68     SPACE eurjchem-11 150 69 763‐771 763‐771 NOUN eurjchem-11 150 70 . . PUNCT eurjchem-11 150 71     SPACE eurjchem-11 151 1 [ [ X eurjchem-11 151 2 6 6 NUM eurjchem-11 151 3 ] ] PUNCT eurjchem-11 151 4 . . PUNCT eurjchem-11 152 1 potkin potkin NOUN eurjchem-11 152 2 , , PUNCT eurjchem-11 152 3     SPACE eurjchem-11 152 4 s. s. PROPN eurjchem-11 152 5     SPACE eurjchem-11 152 6 g. g. PROPN eurjchem-11 152 7 ; ; PUNCT eurjchem-11 152 8     SPACE eurjchem-11 152 9 saha saha NOUN eurjchem-11 152 10 , , PUNCT eurjchem-11 152 11     SPACE eurjchem-11 152 12 a. a. NOUN eurjchem-11 152 13     SPACE eurjchem-11 152 14 r. r. PROPN eurjchem-11 152 15 ; ; PUNCT eurjchem-11 152 16     SPACE eurjchem-11 152 17 kujawa kujawa NOUN eurjchem-11 152 18 , , PUNCT eurjchem-11 152 19     SPACE eurjchem-11 152 20 m. m. NOUN eurjchem-11 152 21     SPACE eurjchem-11 152 22 j. j. PROPN eurjchem-11 152 23 ; ; PUNCT eurjchem-11 152 24     SPACE eurjchem-11 152 25 carson carson PROPN eurjchem-11 152 26 , , PUNCT eurjchem-11 152 27     SPACE eurjchem-11 152 28 w. w. PROPN eurjchem-11 152 29     SPACE eurjchem-11 152 30 h. h. PROPN eurjchem-11 152 31 ; ; PUNCT eurjchem-11 152 32     SPACE eurjchem-11 152 33 ali ali PROPN eurjchem-11 152 34 , , PUNCT eurjchem-11 152 35     SPACE eurjchem-11 152 36 m. m. NOUN eurjchem-11 152 37 ; ; PUNCT eurjchem-11 152 38     SPACE eurjchem-11 152 39 stock stock NOUN eurjchem-11 152 40 , , PUNCT eurjchem-11 152 41     SPACE eurjchem-11 152 42 e. e. PROPN eurjchem-11 152 43 ; ; PUNCT eurjchem-11 152 44     SPACE eurjchem-11 152 45 stringfellow stringfellow PROPN eurjchem-11 152 46 , , PUNCT eurjchem-11 152 47     SPACE eurjchem-11 152 48 j. j. PROPN eurjchem-11 152 49 ; ; PUNCT eurjchem-11 152 50     SPACE eurjchem-11 152 51 ingenito ingenito ADJ eurjchem-11 152 52 , , PUNCT eurjchem-11 152 53     SPACE eurjchem-11 152 54 g. g. NOUN eurjchem-11 152 55 ; ; PUNCT eurjchem-11 152 56     SPACE eurjchem-11 152 57 marder marder NOUN eurjchem-11 152 58 , , PUNCT eurjchem-11 152 59     SPACE eurjchem-11 152 60 s. s. PROPN eurjchem-11 152 61     SPACE eurjchem-11 152 62 r. r. PROPN eurjchem-11 152 63     SPACE eurjchem-11 152 64 arch arch NOUN eurjchem-11 152 65 . . PUNCT eurjchem-11 152 66     SPACE eurjchem-11 153 1 gen gen PROPN eurjchem-11 153 2 . . PROPN eurjchem-11 153 3     SPACE eurjchem-11 153 4 psychiatry psychiatry NOUN eurjchem-11 153 5     SPACE eurjchem-11 153 6 2003 2003 NUM eurjchem-11 153 7 , , PUNCT eurjchem-11 153 8     SPACE eurjchem-11 153 9 60 60 NUM eurjchem-11 153 10 , , PUNCT eurjchem-11 153 11     SPACE eurjchem-11 153 12 681‐690 681‐690 NOUN eurjchem-11 153 13 . . PUNCT eurjchem-11 153 14     SPACE eurjchem-11 154 1 [ [ X eurjchem-11 154 2 7 7 NUM eurjchem-11 154 3 ] ] PUNCT eurjchem-11 154 4 . . PUNCT eurjchem-11 154 5 kasper kasper PROPN eurjchem-11 154 6 , , PUNCT eurjchem-11 154 7     SPACE eurjchem-11 154 8 s. s. PROPN eurjchem-11 154 9 ; ; PUNCT eurjchem-11 154 10     SPACE eurjchem-11 154 11 lerman lerman NOUN eurjchem-11 154 12 , , PUNCT eurjchem-11 154 13     SPACE eurjchem-11 154 14 m. m. NOUN eurjchem-11 154 15     SPACE eurjchem-11 154 16 n. n. PROPN eurjchem-11 154 17 ; ; PUNCT eurjchem-11 154 18     SPACE eurjchem-11 154 19 mcquade mcquade PROPN eurjchem-11 154 20 , , PUNCT eurjchem-11 154 21     SPACE eurjchem-11 154 22 r. r. PROPN eurjchem-11 154 23     SPACE eurjchem-11 154 24 d. d. PROPN eurjchem-11 154 25 ; ; PUNCT eurjchem-11 154 26     SPACE eurjchem-11 154 27 saha saha NOUN eurjchem-11 154 28 , , PUNCT eurjchem-11 154 29     SPACE eurjchem-11 154 30 a. a. NOUN eurjchem-11 154 31 ; ; PUNCT eurjchem-11 154 32     SPACE eurjchem-11 154 33 carson carson PROPN eurjchem-11 154 34 , , PUNCT eurjchem-11 154 35     SPACE eurjchem-11 154 36 w. w. PROPN eurjchem-11 154 37     SPACE eurjchem-11 154 38 h. h. PROPN eurjchem-11 154 39 ; ; PUNCT eurjchem-11 154 40     SPACE eurjchem-11 154 41 ali ali PROPN eurjchem-11 154 42 , , PUNCT eurjchem-11 154 43     SPACE eurjchem-11 154 44 m. m. NOUN eurjchem-11 154 45 ; ; PUNCT eurjchem-11 154 46     SPACE eurjchem-11 154 47 archibald archibald NOUN eurjchem-11 154 48 , , PUNCT eurjchem-11 154 49     SPACE eurjchem-11 154 50 d. d. PROPN eurjchem-11 154 51 ; ; PUNCT eurjchem-11 154 52     SPACE eurjchem-11 154 53 ingenito ingenito ADJ eurjchem-11 154 54 , , PUNCT eurjchem-11 154 55     SPACE eurjchem-11 154 56 g. g. NOUN eurjchem-11 154 57 ; ; PUNCT eurjchem-11 154 58     SPACE eurjchem-11 154 59 marcus marcus PROPN eurjchem-11 154 60 , , PUNCT eurjchem-11 154 61     SPACE eurjchem-11 154 62 r. r. PROPN eurjchem-11 154 63 ; ; PUNCT eurjchem-11 154 64     SPACE eurjchem-11 154 65 pigott pigott NOUN eurjchem-11 154 66 , , PUNCT eurjchem-11 154 67     SPACE eurjchem-11 154 68 t. t. PROPN eurjchem-11 154 69     SPACE eurjchem-11 154 70 int int NOUN eurjchem-11 154 71 . . PUNCT eurjchem-11 154 72     SPACE eurjchem-11 155 1 j. j. PROPN eurjchem-11 155 2     SPACE eurjchem-11 155 3 neuropsychopharmacol neuropsychopharmacol PROPN eurjchem-11 155 4 . . PUNCT eurjchem-11 155 5     SPACE eurjchem-11 155 6 2003 2003 NUM eurjchem-11 155 7 , , PUNCT eurjchem-11 155 8     SPACE eurjchem-11 155 9 6 6 NUM eurjchem-11 155 10 , , PUNCT eurjchem-11 155 11     SPACE eurjchem-11 155 12 325‐337 325‐337 NUM eurjchem-11 155 13 . . PUNCT eurjchem-11 155 14     SPACE eurjchem-11 156 1 [ [ X eurjchem-11 156 2 8 8 NUM eurjchem-11 156 3 ] ] PUNCT eurjchem-11 156 4 . . PUNCT eurjchem-11 157 1 ribeiro ribeiro PROPN eurjchem-11 157 2 , , PUNCT eurjchem-11 157 3     SPACE eurjchem-11 157 4 y. y. NOUN eurjchem-11 157 5     SPACE eurjchem-11 157 6 a. a. NOUN eurjchem-11 157 7 ; ; PUNCT eurjchem-11 157 8     SPACE eurjchem-11 157 9 de de PROPN eurjchem-11 157 10     SPACE eurjchem-11 157 11 oliveira oliveira PROPN eurjchem-11 157 12 , , PUNCT eurjchem-11 157 13     SPACE eurjchem-11 157 14 j. j. PROPN eurjchem-11 157 15     SPACE eurjchem-11 157 16 d. d. PROPN eurjchem-11 157 17     SPACE eurjchem-11 157 18 s. s. PROPN eurjchem-11 157 19 ; ; PUNCT eurjchem-11 157 20     SPACE eurjchem-11 157 21 leles lele NOUN eurjchem-11 157 22 , , PUNCT eurjchem-11 157 23     SPACE eurjchem-11 157 24 m. m. NOUN eurjchem-11 157 25     SPACE eurjchem-11 157 26 i. i. PROPN eurjchem-11 157 27     SPACE eurjchem-11 157 28 g. g. PROPN eurjchem-11 157 29 ; ; PUNCT eurjchem-11 157 30     SPACE eurjchem-11 157 31 juiz juiz PROPN eurjchem-11 157 32 , , PUNCT eurjchem-11 157 33     SPACE eurjchem-11 157 34 s. s. PROPN eurjchem-11 157 35     SPACE eurjchem-11 157 36 a. a. NOUN eurjchem-11 157 37 ; ; PUNCT eurjchem-11 157 38     SPACE eurjchem-11 157 39 ionashiro ionashiro NOUN eurjchem-11 157 40 , , PUNCT eurjchem-11 157 41     SPACE eurjchem-11 157 42 m. m. NOUN eurjchem-11 157 43     SPACE eurjchem-11 157 44 j. j. PROPN eurjchem-11 157 45     SPACE eurjchem-11 157 46 therm therm PROPN eurjchem-11 157 47 . . PUNCT eurjchem-11 157 48     SPACE eurjchem-11 157 49 anal anal ADJ eurjchem-11 157 50 . . PUNCT eurjchem-11 157 51     SPACE eurjchem-11 157 52 1996 1996 NUM eurjchem-11 157 53 , , PUNCT eurjchem-11 157 54     SPACE eurjchem-11 157 55 46 46 NUM eurjchem-11 157 56 , , PUNCT eurjchem-11 157 57     SPACE eurjchem-11 157 58 1645‐1655 1645‐1655 PROPN eurjchem-11 157 59 . . PUNCT eurjchem-11 157 60     SPACE eurjchem-11 158 1 [ [ X eurjchem-11 158 2 9 9 NUM eurjchem-11 158 3 ] ] PUNCT eurjchem-11 158 4 . . PUNCT eurjchem-11 159 1 zhou zhou PROPN eurjchem-11 159 2 , , PUNCT eurjchem-11 159 3     SPACE eurjchem-11 159 4 w. w. NOUN eurjchem-11 159 5 ; ; PUNCT eurjchem-11 159 6     SPACE eurjchem-11 159 7 gilpin gilpin NOUN eurjchem-11 159 8 , , PUNCT eurjchem-11 159 9     SPACE eurjchem-11 159 10 r. r. PROPN eurjchem-11 159 11     SPACE eurjchem-11 159 12 k. k. PROPN eurjchem-11 159 13     SPACE eurjchem-11 159 14 j. j. PROPN eurjchem-11 159 15     SPACE eurjchem-11 159 16 pharm pharm PROPN eurjchem-11 159 17 . . PUNCT eurjchem-11 159 18     SPACE eurjchem-11 159 19 sci sci PROPN eurjchem-11 159 20 . . PUNCT eurjchem-11 159 21     SPACE eurjchem-11 159 22 2004 2004 NUM eurjchem-11 159 23 , , PUNCT eurjchem-11 159 24     SPACE eurjchem-11 159 25 93 93 NUM eurjchem-11 159 26 , , PUNCT eurjchem-11 159 27     SPACE eurjchem-11 159 28 1545‐1556 1545‐1556 NUM eurjchem-11 159 29 . . PUNCT eurjchem-11 159 30     SPACE eurjchem-11 160 1 [ [ X eurjchem-11 160 2 10 10 NUM eurjchem-11 160 3 ] ] PUNCT eurjchem-11 160 4 . . PUNCT eurjchem-11 160 5 berridge berridge PROPN eurjchem-11 160 6 , , PUNCT eurjchem-11 160 7     SPACE eurjchem-11 160 8 j. j. PROPN eurjchem-11 160 9     SPACE eurjchem-11 160 10 c. c. PROPN eurjchem-11 160 11     SPACE eurjchem-11 160 12 j. j. PROPN eurjchem-11 160 13     SPACE eurjchem-11 160 14 pharm pharm PROPN eurjchem-11 160 15 . . PUNCT eurjchem-11 160 16     SPACE eurjchem-11 160 17 biomed biome VERB eurjchem-11 160 18 . . PUNCT eurjchem-11 160 19     SPACE eurjchem-11 160 20 anal anal ADJ eurjchem-11 160 21 . . PUNCT eurjchem-11 160 22     SPACE eurjchem-11 160 23 1995 1995 NUM eurjchem-11 160 24 , , PUNCT eurjchem-11 160 25     SPACE eurjchem-11 160 26 14 14 NUM eurjchem-11 160 27 , , PUNCT eurjchem-11 160 28     SPACE eurjchem-11 160 29 7‐12 7‐12 NUM eurjchem-11 160 30 . . PUNCT eurjchem-11 160 31         SPACE eurjchem-11 161 1 [ [ X eurjchem-11 161 2 11 11 NUM eurjchem-11 161 3 ] ] PUNCT eurjchem-11 161 4 . . PUNCT eurjchem-11 162 1 branch branch NOUN eurjchem-11 162 2 , , PUNCT eurjchem-11 162 3     SPACE eurjchem-11 162 4 s.k s.k PROPN eurjchem-11 162 5 . . PROPN eurjchem-11 162 6     SPACE eurjchem-11 162 7 j. j. PROPN eurjchem-11 162 8     SPACE eurjchem-11 162 9 pharm pharm PROPN eurjchem-11 162 10 . . PUNCT eurjchem-11 162 11     SPACE eurjchem-11 162 12 biomed biome VERB eurjchem-11 162 13 . . PUNCT eurjchem-11 162 14     SPACE eurjchem-11 162 15 anal anal ADJ eurjchem-11 162 16 . . PUNCT eurjchem-11 162 17     SPACE eurjchem-11 162 18 2005 2005 NUM eurjchem-11 162 19 , , PUNCT eurjchem-11 162 20     SPACE eurjchem-11 162 21 38 38 NUM eurjchem-11 162 22 , , PUNCT eurjchem-11 162 23     SPACE eurjchem-11 162 24 798‐805 798‐805 NUM eurjchem-11 162 25 . . PUNCT eurjchem-11 162 26     SPACE eurjchem-11 163 1 [ [ X eurjchem-11 163 2 12 12 NUM eurjchem-11 163 3 ] ] PUNCT eurjchem-11 163 4 . . PUNCT eurjchem-11 164 1 roy roy PROPN eurjchem-11 164 2 , , PUNCT eurjchem-11 164 3     SPACE eurjchem-11 164 4 j. j. PROPN eurjchem-11 164 5     SPACE eurjchem-11 164 6 aaps aap NOUN eurjchem-11 164 7     SPACE eurjchem-11 164 8 pharmscitech pharmscitech NOUN eurjchem-11 164 9     SPACE eurjchem-11 164 10 2002 2002 NUM eurjchem-11 164 11 , , PUNCT eurjchem-11 164 12     SPACE eurjchem-11 164 13 3 3 NUM eurjchem-11 164 14 , , PUNCT eurjchem-11 164 15     SPACE eurjchem-11 164 16 1‐8 1‐8 NOUN eurjchem-11 164 17 . . PUNCT eurjchem-11 164 18     SPACE eurjchem-11 165 1 [ [ X eurjchem-11 165 2 13 13 NUM eurjchem-11 165 3 ] ] PUNCT eurjchem-11 165 4 . . PUNCT eurjchem-11 166 1 zuo zuo PROPN eurjchem-11 166 2 , , PUNCT eurjchem-11 166 3     SPACE eurjchem-11 166 4 x. x. NOUN eurjchem-11 166 5     SPACE eurjchem-11 166 6 c. c. PROPN eurjchem-11 166 7 ; ; PUNCT eurjchem-11 166 8     SPACE eurjchem-11 166 9 wang wang PROPN eurjchem-11 166 10 , , PUNCT eurjchem-11 166 11     SPACE eurjchem-11 166 12 f. f. PROPN eurjchem-11 166 13 ; ; PUNCT eurjchem-11 166 14     SPACE eurjchem-11 166 15 xu xu PROPN eurjchem-11 166 16 , , PUNCT eurjchem-11 166 17     SPACE eurjchem-11 166 18 p. p. NOUN eurjchem-11 166 19 ; ; PUNCT eurjchem-11 166 20     SPACE eurjchem-11 166 21 zhu zhu PROPN eurjchem-11 166 22 , , PUNCT eurjchem-11 166 23     SPACE eurjchem-11 166 24 r. r. PROPN eurjchem-11 166 25     SPACE eurjchem-11 166 26 h. h. PROPN eurjchem-11 166 27 ; ; PUNCT eurjchem-11 166 28     SPACE eurjchem-11 166 29 li li PROPN eurjchem-11 166 30 , , PUNCT eurjchem-11 166 31     SPACE eurjchem-11 166 32 h. h. PROPN eurjchem-11 166 33     SPACE eurjchem-11 166 34 d. d. PROPN eurjchem-11 166 35     SPACE eurjchem-11 166 36 chromatographia chromatographia PROPN eurjchem-11 166 37 , , PUNCT eurjchem-11 166 38     SPACE eurjchem-11 166 39 2006 2006 NUM eurjchem-11 166 40 , , PUNCT eurjchem-11 166 41     SPACE eurjchem-11 166 42 64 64 NUM eurjchem-11 166 43 , , PUNCT eurjchem-11 166 44     SPACE eurjchem-11 166 45 387‐391 387‐391 NUM eurjchem-11 166 46 . . PUNCT eurjchem-11 166 47     SPACE eurjchem-11 167 1 reddy reddy PROPN eurjchem-11 167 2     SPACE eurjchem-11 167 3 et et PROPN eurjchem-11 167 4     SPACE eurjchem-11 167 5 al al PROPN eurjchem-11 167 6 . . PROPN eurjchem-11 167 7     SPACE eurjchem-11 167 8 / / SYM eurjchem-11 167 9     SPACE eurjchem-11 167 10 european european ADJ eurjchem-11 167 11     SPACE eurjchem-11 167 12 journal journal NOUN eurjchem-11 167 13     SPACE eurjchem-11 167 14 of of ADP eurjchem-11 167 15     SPACE eurjchem-11 167 16 chemistry chemistry NOUN eurjchem-11 167 17     SPACE eurjchem-11 167 18 1 1 NUM eurjchem-11 167 19     SPACE eurjchem-11 167 20 ( ( PUNCT eurjchem-11 167 21 1 1 NUM eurjchem-11 167 22 ) ) PUNCT eurjchem-11 167 23     SPACE eurjchem-11 167 24 ( ( PUNCT eurjchem-11 167 25 2010 2010 NUM eurjchem-11 167 26 ) ) PUNCT eurjchem-11 167 27     SPACE eurjchem-11 168 1 20­27 20­27 NUM eurjchem-11 168 2     SPACE eurjchem-11 168 3 27 27 NUM eurjchem-11 168 4     SPACE eurjchem-11 168 5 [ [ X eurjchem-11 168 6 14 14 NUM eurjchem-11 168 7 ] ] PUNCT eurjchem-11 168 8 . . PUNCT eurjchem-11 169 1 masanori masanori NOUN eurjchem-11 169 2 , , PUNCT eurjchem-11 169 3     SPACE eurjchem-11 169 4 k. k. PROPN eurjchem-11 169 5 ; ; PUNCT eurjchem-11 169 6     SPACE eurjchem-11 169 7 yasuo yasuo NOUN eurjchem-11 169 8 , , PUNCT eurjchem-11 169 9     SPACE eurjchem-11 169 10 m. m. NOUN eurjchem-11 169 11 ; ; PUNCT eurjchem-11 169 12     SPACE eurjchem-11 169 13 yukihiro yukihiro PROPN eurjchem-11 169 14 , , PUNCT eurjchem-11 169 15     SPACE eurjchem-11 169 16 h. h. PROPN eurjchem-11 169 17 ; ; PUNCT eurjchem-11 169 18     SPACE eurjchem-11 169 19 takahiko takahiko NOUN eurjchem-11 169 20 , , PUNCT eurjchem-11 169 21     SPACE eurjchem-11 169 22 o. o. PROPN eurjchem-11 169 23     SPACE eurjchem-11 169 24 j. j. PROPN eurjchem-11 169 25     SPACE eurjchem-11 169 26 chromatogr chromatogr PROPN eurjchem-11 169 27 . . PUNCT eurjchem-11 169 28     SPACE eurjchem-11 170 1 b b X eurjchem-11 170 2     SPACE eurjchem-11 170 3 2005 2005 NUM eurjchem-11 170 4 , , PUNCT eurjchem-11 170 5     SPACE eurjchem-11 170 6 822 822 NUM eurjchem-11 170 7 , , PUNCT eurjchem-11 170 8     SPACE eurjchem-11 170 9 294‐299 294‐299 PROPN eurjchem-11 170 10 . . PUNCT eurjchem-11 170 11       SPACE eurjchem-11 171 1 [ [ X eurjchem-11 171 2 15 15 NUM eurjchem-11 171 3 ] ] PUNCT eurjchem-11 171 4 . . PUNCT eurjchem-11 172 1 hui‐ching hui‐che VERB eurjchem-11 172 2 , , PUNCT eurjchem-11 172 3     SPACE eurjchem-11 172 4 h. h. NOUN eurjchem-11 172 5 ; ; PUNCT eurjchem-11 172 6     SPACE eurjchem-11 172 7 chin‐hung chin‐hung PROPN eurjchem-11 172 8 , , PUNCT eurjchem-11 172 9     SPACE eurjchem-11 172 10 l. l. PROPN eurjchem-11 172 11 ; ; PUNCT eurjchem-11 172 12     SPACE eurjchem-11 172 13 tsuo‐hung tsuo‐hung PROPN eurjchem-11 172 14 , , PUNCT eurjchem-11 172 15     SPACE eurjchem-11 172 16 l. l. PROPN eurjchem-11 172 17 ; ; PUNCT eurjchem-11 172 18     SPACE eurjchem-11 172 19 tsung‐ming tsung‐ming NOUN eurjchem-11 172 20 , , PUNCT eurjchem-11 172 21     SPACE eurjchem-11 172 22 h. h. PROPN eurjchem-11 172 23 ; ; PUNCT eurjchem-11 172 24     SPACE eurjchem-11 172 25 hsien‐ hsien‐ X eurjchem-11 172 26 jane jane NOUN eurjchem-11 172 27 , , PUNCT eurjchem-11 172 28     SPACE eurjchem-11 172 29 c. c. NOUN eurjchem-11 172 30 ; ; PUNCT eurjchem-11 172 31     SPACE eurjchem-11 172 32 yu‐chun yu‐chun PROPN eurjchem-11 172 33 , , PUNCT eurjchem-11 172 34     SPACE eurjchem-11 172 35 w. w. PROPN eurjchem-11 172 36 ; ; PUNCT eurjchem-11 172 37     SPACE eurjchem-11 172 38 ying ying PROPN eurjchem-11 172 39     SPACE eurjchem-11 172 40 lung lung NOUN eurjchem-11 172 41 , , PUNCT eurjchem-11 172 42     SPACE eurjchem-11 172 43 t. t. PROPN eurjchem-11 172 44     SPACE eurjchem-11 172 45 j. j. PROPN eurjchem-11 172 46     SPACE eurjchem-11 172 47 chromatogr chromatogr PROPN eurjchem-11 172 48 . . PUNCT eurjchem-11 172 49     SPACE eurjchem-11 173 1 b b NOUN eurjchem-11 173 2 , , PUNCT eurjchem-11 173 3     SPACE eurjchem-11 173 4 2007 2007 NUM eurjchem-11 173 5 , , PUNCT eurjchem-11 173 6     SPACE eurjchem-11 173 7 856 856 NUM eurjchem-11 173 8 , , PUNCT eurjchem-11 173 9     SPACE eurjchem-11 173 10 57‐61 57‐61 NUM eurjchem-11 173 11 . . PUNCT eurjchem-11 173 12     SPACE eurjchem-11 174 1 [ [ X eurjchem-11 174 2 16 16 NUM eurjchem-11 174 3 ] ] PUNCT eurjchem-11 174 4 . . PUNCT eurjchem-11 175 1 shah shah PROPN eurjchem-11 175 2 , , PUNCT eurjchem-11 175 3     SPACE eurjchem-11 175 4 v. v. ADP eurjchem-11 175 5     SPACE eurjchem-11 175 6 p. p. NOUN eurjchem-11 175 7 ; ; PUNCT eurjchem-11 175 8     SPACE eurjchem-11 175 9 kamal kamal PROPN eurjchem-11 175 10 , , PUNCT eurjchem-11 175 11     SPACE eurjchem-11 175 12 k. k. PROPN eurjchem-11 175 13     SPACE eurjchem-11 175 14 m. m. NOUN eurjchem-11 175 15 ; ; PUNCT eurjchem-11 175 16     SPACE eurjchem-11 175 17 shrikant shrikant ADJ eurjchem-11 175 18 , , PUNCT eurjchem-11 175 19     SPACE eurjchem-11 175 20 d. d. PROPN eurjchem-11 175 21 ; ; PUNCT eurjchem-11 175 22     SPACE eurjchem-11 175 23 iain iain NOUN eurjchem-11 175 24 , , PUNCT eurjchem-11 175 25     SPACE eurjchem-11 175 26 j. j. PROPN eurjchem-11 175 27     SPACE eurjchem-11 175 28 m. m. NOUN eurjchem-11 175 29 ; ; PUNCT eurjchem-11 175 30     SPACE eurjchem-11 175 31 jerome jerome PROPN eurjchem-11 175 32 , , PUNCT eurjchem-11 175 33     SPACE eurjchem-11 175 34 p. p. NOUN eurjchem-11 175 35     SPACE eurjchem-11 175 36 s. s. PROPN eurjchem-11 175 37 ; ; PUNCT eurjchem-11 175 38     SPACE eurjchem-11 175 39 avraham avraham NOUN eurjchem-11 175 40 , , PUNCT eurjchem-11 175 41     SPACE eurjchem-11 175 42 y. y. NOUN eurjchem-11 175 43 ; ; PUNCT eurjchem-11 175 44     SPACE eurjchem-11 175 45 thomas thomas PROPN eurjchem-11 175 46 , , PUNCT eurjchem-11 175 47     SPACE eurjchem-11 175 48 l. l. PROPN eurjchem-11 175 49 ; ; PUNCT eurjchem-11 175 50     SPACE eurjchem-11 175 51 viswanathan viswanathan PROPN eurjchem-11 175 52 , , PUNCT eurjchem-11 175 53     SPACE eurjchem-11 175 54 c. c. PROPN eurjchem-11 175 55     SPACE eurjchem-11 175 56 t. t. PROPN eurjchem-11 175 57 ; ; PUNCT eurjchem-11 175 58     SPACE eurjchem-11 175 59 edgar edgar NOUN eurjchem-11 175 60 , , PUNCT eurjchem-11 175 61     SPACE eurjchem-11 175 62 c. c. NOUN eurjchem-11 175 63 ; ; PUNCT eurjchem-11 175 64     SPACE eurjchem-11 175 65 mcdowall mcdowall NOUN eurjchem-11 175 66 , , PUNCT eurjchem-11 175 67     SPACE eurjchem-11 175 68 r. r. PROPN eurjchem-11 175 69     SPACE eurjchem-11 175 70 d. d. PROPN eurjchem-11 175 71 ; ; PUNCT eurjchem-11 175 72     SPACE eurjchem-11 175 73 kenneth kenneth PROPN eurjchem-11 175 74 , , PUNCT eurjchem-11 175 75     SPACE eurjchem-11 175 76 a. a. NOUN eurjchem-11 175 77     SPACE eurjchem-11 175 78 p. p. NOUN eurjchem-11 175 79 ; ; PUNCT eurjchem-11 175 80     SPACE eurjchem-11 175 81 sidney sidney NOUN eurjchem-11 175 82 , , PUNCT eurjchem-11 175 83     SPACE eurjchem-11 175 84 s. s. PROPN eurjchem-11 175 85     SPACE eurjchem-11 175 86 j. j. PROPN eurjchem-11 175 87     SPACE eurjchem-11 175 88 pharm pharm PROPN eurjchem-11 175 89 . . PUNCT eurjchem-11 175 90     SPACE eurjchem-11 176 1 sci sci PROPN eurjchem-11 176 2 . . PUNCT eurjchem-11 176 3     SPACE eurjchem-11 176 4 1992 1992 NUM eurjchem-11 176 5 , , PUNCT eurjchem-11 176 6     SPACE eurjchem-11 176 7 81 81 NUM eurjchem-11 176 8 , , PUNCT eurjchem-11 176 9     SPACE eurjchem-11 176 10 309‐312 309‐312 NUM eurjchem-11 176 11 . . PUNCT eurjchem-11 176 12       SPACE eurjchem-11 177 1 [ [ X eurjchem-11 177 2 17 17 NUM eurjchem-11 177 3 ] ] PUNCT eurjchem-11 177 4 . . PUNCT eurjchem-11 178 1 zha zha PROPN eurjchem-11 178 2 , , PUNCT eurjchem-11 178 3     SPACE eurjchem-11 178 4 j. j. PROPN eurjchem-11 178 5     SPACE eurjchem-11 178 6 p. p. PROPN eurjchem-11 178 7 , , PUNCT eurjchem-11 178 8     SPACE eurjchem-11 178 9 xu xu PROPN eurjchem-11 178 10 , , PUNCT eurjchem-11 178 11     SPACE eurjchem-11 178 12 h. h. PROPN eurjchem-11 178 13     SPACE eurjchem-11 178 14 j. j. PROPN eurjchem-11 178 15 , , PUNCT eurjchem-11 178 16     SPACE eurjchem-11 178 17 wang wang PROPN eurjchem-11 178 18 , , PUNCT eurjchem-11 178 19     SPACE eurjchem-11 178 20 y. y. NOUN eurjchem-11 178 21     SPACE eurjchem-11 178 22 z. z. PROPN eurjchem-11 178 23 , , PUNCT eurjchem-11 178 24     SPACE eurjchem-11 178 25 yang yang PROPN eurjchem-11 178 26 , , PUNCT eurjchem-11 178 27     SPACE eurjchem-11 178 28 s. s. PROPN eurjchem-11 178 29     SPACE eurjchem-11 178 30 g. g. PROPN eurjchem-11 178 31 , , PUNCT eurjchem-11 178 32     SPACE eurjchem-11 178 33 jia jia PROPN eurjchem-11 178 34 , , PUNCT eurjchem-11 178 35     SPACE eurjchem-11 178 36 c. c. PROPN eurjchem-11 178 37     SPACE eurjchem-11 178 38 x. x. PROPN eurjchem-11 178 39 , , PUNCT eurjchem-11 178 40     SPACE eurjchem-11 178 41 hou hou PROPN eurjchem-11 178 42 , , PUNCT eurjchem-11 178 43     SPACE eurjchem-11 178 44 z. z. PROPN eurjchem-11 178 45     SPACE eurjchem-11 178 46 f. f. PROPN eurjchem-11 178 47     SPACE eurjchem-11 178 48 chin chin PROPN eurjchem-11 178 49 . . PUNCT eurjchem-11 178 50     SPACE eurjchem-11 178 51 pharm pharm PROPN eurjchem-11 178 52 . . PUNCT eurjchem-11 178 53     SPACE eurjchem-11 179 1 j. j. PROPN eurjchem-11 179 2     SPACE eurjchem-11 179 3 2005 2005 NUM eurjchem-11 179 4 , , PUNCT eurjchem-11 179 5     SPACE eurjchem-11 179 6 40 40 NUM eurjchem-11 179 7 , , PUNCT eurjchem-11 179 8     SPACE eurjchem-11 179 9 137‐139 137‐139 NUM eurjchem-11 179 10 . . PUNCT eurjchem-11 179 11       SPACE eurjchem-11 180 1 [ [ X eurjchem-11 180 2 18 18 NUM eurjchem-11 180 3 ] ] PUNCT eurjchem-11 180 4 . . PUNCT eurjchem-11 181 1 srinivas srinivas PROPN eurjchem-11 181 2 , , PUNCT eurjchem-11 181 3     SPACE eurjchem-11 181 4 k. k. PROPN eurjchem-11 181 5     SPACE eurjchem-11 181 6 s. s. PROPN eurjchem-11 181 7     SPACE eurjchem-11 181 8 v. v. PROPN eurjchem-11 181 9 ; ; PUNCT eurjchem-11 181 10     SPACE eurjchem-11 181 11 buchireddy buchireddy NOUN eurjchem-11 181 12 , , PUNCT eurjchem-11 181 13     SPACE eurjchem-11 181 14 r. r. PROPN eurjchem-11 181 15 ; ; PUNCT eurjchem-11 181 16     SPACE eurjchem-11 181 17 madhusudhan madhusudhan NOUN eurjchem-11 181 18 , , PUNCT eurjchem-11 181 19     SPACE eurjchem-11 181 20 g. g. NOUN eurjchem-11 181 21 ; ; PUNCT eurjchem-11 181 22     SPACE eurjchem-11 181 23 mukkanti mukkanti NOUN eurjchem-11 181 24 , , PUNCT eurjchem-11 181 25     SPACE eurjchem-11 181 26 k. k. NOUN eurjchem-11 181 27 ; ; PUNCT eurjchem-11 181 28     SPACE eurjchem-11 181 29 srinivasulu srinivasulu ADJ eurjchem-11 181 30 , , PUNCT eurjchem-11 181 31     SPACE eurjchem-11 181 32 p. p. NOUN eurjchem-11 181 33     SPACE eurjchem-11 181 34 chromatographia chromatographia NOUN eurjchem-11 181 35     SPACE eurjchem-11 181 36 2008 2008 NUM eurjchem-11 181 37 , , PUNCT eurjchem-11 181 38     SPACE eurjchem-11 181 39 68 68 NUM eurjchem-11 181 40 , , PUNCT eurjchem-11 181 41     SPACE eurjchem-11 181 42 635‐640 635‐640 NOUN eurjchem-11 181 43 . . PUNCT eurjchem-11 181 44     SPACE eurjchem-11 182 1 [ [ X eurjchem-11 182 2 19 19 NUM eurjchem-11 182 3 ] ] PUNCT eurjchem-11 182 4 . . PUNCT eurjchem-11 183 1 ich ich NOUN eurjchem-11 183 2     SPACE eurjchem-11 183 3 topic topic NOUN eurjchem-11 183 4     SPACE eurjchem-11 183 5 q1a q1a NOUN eurjchem-11 183 6     SPACE eurjchem-11 183 7 ( ( PUNCT eurjchem-11 183 8 r2 r2 PROPN eurjchem-11 183 9 ) ) PUNCT eurjchem-11 183 10     SPACE eurjchem-11 183 11 2003 2003 NUM eurjchem-11 183 12     SPACE eurjchem-11 183 13 stability stability NOUN eurjchem-11 183 14     SPACE eurjchem-11 183 15 testing testing NOUN eurjchem-11 183 16     SPACE eurjchem-11 183 17 of of ADP eurjchem-11 183 18     SPACE eurjchem-11 183 19 new new ADJ eurjchem-11 183 20     SPACE eurjchem-11 183 21 drug drug NOUN eurjchem-11 183 22     SPACE eurjchem-11 183 23 substances substance NOUN eurjchem-11 183 24     SPACE eurjchem-11 183 25 and and CCONJ eurjchem-11 183 26     SPACE eurjchem-11 183 27 products product NOUN eurjchem-11 183 28 , , PUNCT eurjchem-11 183 29     SPACE eurjchem-11 183 30 cpmp cpmp NOUN eurjchem-11 183 31 / / SYM eurjchem-11 183 32 ich/2736/99 ich/2736/99 NOUN eurjchem-11 183 33 . . PUNCT eurjchem-11 183 34     SPACE eurjchem-11 184 1 [ [ X eurjchem-11 184 2 20 20 NUM eurjchem-11 184 3 ] ] PUNCT eurjchem-11 184 4 . . PUNCT eurjchem-11 185 1 lacorte lacorte PROPN eurjchem-11 185 2 , , PUNCT eurjchem-11 185 3     SPACE eurjchem-11 185 4 s. s. PROPN eurjchem-11 185 5 ; ; PUNCT eurjchem-11 185 6     SPACE eurjchem-11 185 7 fernandez‐alba fernandez‐alba PROPN eurjchem-11 185 8 , , PUNCT eurjchem-11 185 9     SPACE eurjchem-11 185 10 a. a. NOUN eurjchem-11 185 11     SPACE eurjchem-11 185 12 r. r. PROPN eurjchem-11 185 13     SPACE eurjchem-11 185 14 mass mass PROPN eurjchem-11 185 15     SPACE eurjchem-11 185 16 spectrom spectrom NOUN eurjchem-11 185 17 . . PUNCT eurjchem-11 185 18     SPACE eurjchem-11 185 19 rev rev VERB eurjchem-11 185 20 . . PUNCT eurjchem-11 185 21     SPACE eurjchem-11 185 22 2006 2006 NUM eurjchem-11 185 23 , , PUNCT eurjchem-11 185 24     SPACE eurjchem-11 185 25 25 25 NUM eurjchem-11 185 26 , , PUNCT eurjchem-11 185 27     SPACE eurjchem-11 185 28 866‐ 866‐ NUM eurjchem-11 185 29 880 880 NUM eurjchem-11 185 30 . . PUNCT eurjchem-11 185 31       SPACE eurjchem-11 186 1 [ [ X eurjchem-11 186 2 21 21 NUM eurjchem-11 186 3 ] ] PUNCT eurjchem-11 186 4 . . PUNCT eurjchem-11 187 1 schmid schmid PROPN eurjchem-11 187 2 , , PUNCT eurjchem-11 187 3     SPACE eurjchem-11 187 4 r. r. PROPN eurjchem-11 187 5     SPACE eurjchem-11 187 6 p. p. PROPN eurjchem-11 187 7 ; ; PUNCT eurjchem-11 187 8     SPACE eurjchem-11 187 9 weickhardt weickhardt ADJ eurjchem-11 187 10 , , PUNCT eurjchem-11 187 11     SPACE eurjchem-11 187 12 c. c. PROPN eurjchem-11 187 13     SPACE eurjchem-11 187 14 int int NOUN eurjchem-11 187 15 . . PUNCT eurjchem-11 187 16     SPACE eurjchem-11 187 17 j. j. PROPN eurjchem-11 187 18     SPACE eurjchem-11 187 19 mass mass PROPN eurjchem-11 187 20     SPACE eurjchem-11 187 21 spectrom spectrom NOUN eurjchem-11 187 22 . . PUNCT eurjchem-11 187 23     SPACE eurjchem-11 187 24 2001 2001 NUM eurjchem-11 187 25 , , PUNCT eurjchem-11 187 26     SPACE eurjchem-11 187 27 206 206 NUM eurjchem-11 187 28 , , PUNCT eurjchem-11 187 29     SPACE eurjchem-11 187 30 181‐ 181‐ NUM eurjchem-11 187 31 190 190 NUM eurjchem-11 187 32 . . PUNCT eurjchem-11 187 33       SPACE eurjchem-11 188 1 [ [ X eurjchem-11 188 2 22 22 NUM eurjchem-11 188 3 ] ] PUNCT eurjchem-11 188 4 . . PUNCT eurjchem-11 189 1 ferrer ferrer PROPN eurjchem-11 189 2 , , PUNCT eurjchem-11 189 3     SPACE eurjchem-11 189 4 i. i. NOUN eurjchem-11 189 5 ; ; PUNCT eurjchem-11 189 6     SPACE eurjchem-11 189 7 garcı´a‐reyes garcı´a‐reye NOUN eurjchem-11 189 8 , , PUNCT eurjchem-11 189 9     SPACE eurjchem-11 189 10 j. j. PROPN eurjchem-11 189 11     SPACE eurjchem-11 189 12 f. f. PROPN eurjchem-11 189 13 ; ; PUNCT eurjchem-11 189 14     SPACE eurjchem-11 189 15 fernandez‐alba fernandez‐alba PROPN eurjchem-11 189 16 , , PUNCT eurjchem-11 189 17     SPACE eurjchem-11 189 18 a. a. NOUN eurjchem-11 189 19     SPACE eurjchem-11 189 20 trends trend NOUN eurjchem-11 189 21     SPACE eurjchem-11 189 22 in in ADP eurjchem-11 189 23     SPACE eurjchem-11 189 24 anal anal NOUN eurjchem-11 189 25 . . PUNCT eurjchem-11 189 26     SPACE eurjchem-11 189 27 chem chem NOUN eurjchem-11 189 28 . . PUNCT eurjchem-11 189 29     SPACE eurjchem-11 189 30 2005 2005 NUM eurjchem-11 189 31 , , PUNCT eurjchem-11 189 32     SPACE eurjchem-11 189 33 24 24 NUM eurjchem-11 189 34 , , PUNCT eurjchem-11 189 35     SPACE eurjchem-11 189 36 2005 2005 NUM eurjchem-11 189 37 . . PUNCT eurjchem-11 189 38     SPACE eurjchem-11 190 1 [ [ X eurjchem-11 190 2 23 23 NUM eurjchem-11 190 3 ] ] PUNCT eurjchem-11 190 4 . . PUNCT eurjchem-11 191 1 petrovic petrovic PROPN eurjchem-11 191 2 , , PUNCT eurjchem-11 191 3     SPACE eurjchem-11 191 4 m. m. NOUN eurjchem-11 191 5 ; ; PUNCT eurjchem-11 191 6     SPACE eurjchem-11 191 7 gros gro NOUN eurjchem-11 191 8 , , PUNCT eurjchem-11 191 9     SPACE eurjchem-11 191 10 m. m. NOUN eurjchem-11 191 11 ; ; PUNCT eurjchem-11 191 12     SPACE eurjchem-11 191 13 barcelo barcelo NOUN eurjchem-11 191 14 , , PUNCT eurjchem-11 191 15     SPACE eurjchem-11 191 16 d. d. PROPN eurjchem-11 191 17     SPACE eurjchem-11 191 18 j. j. PROPN eurjchem-11 191 19     SPACE eurjchem-11 191 20 chromatogr chromatogr PROPN eurjchem-11 191 21 . . PUNCT eurjchem-11 191 22     SPACE eurjchem-11 192 1 a a DET eurjchem-11 192 2     SPACE eurjchem-11 192 3 2006 2006 NUM eurjchem-11 192 4 , , PUNCT eurjchem-11 192 5     SPACE eurjchem-11 192 6 1124 1124 NUM eurjchem-11 192 7 , , PUNCT eurjchem-11 192 8     SPACE eurjchem-11 192 9 68‐81 68‐81 NOUN eurjchem-11 192 10 . . PUNCT eurjchem-11 192 11     SPACE eurjchem-11 193 1 [ [ X eurjchem-11 193 2 24 24 NUM eurjchem-11 193 3 ] ] PUNCT eurjchem-11 193 4 . . PUNCT eurjchem-11 194 1 ( ( PUNCT eurjchem-11 194 2 wo/2003/064393 wo/2003/064393 PROPN eurjchem-11 194 3 ) ) PUNCT eurjchem-11 194 4     SPACE eurjchem-11 194 5 thio‐carbostyril thio‐carbostyril NOUN eurjchem-11 194 6     SPACE eurjchem-11 194 7 derivative derivative NOUN eurjchem-11 194 8 , , PUNCT eurjchem-11 194 9     SPACE eurjchem-11 194 10 its its PRON eurjchem-11 194 11     SPACE eurjchem-11 194 12 n‐oxides n‐oxide NOUN eurjchem-11 194 13     SPACE eurjchem-11 194 14 and and CCONJ eurjchem-11 194 15     SPACE eurjchem-11 194 16 the the DET eurjchem-11 194 17     SPACE eurjchem-11 194 18 n‐oxides n‐oxide NOUN eurjchem-11 194 19     SPACE eurjchem-11 194 20 of of ADP eurjchem-11 194 21     SPACE eurjchem-11 194 22 aripiprazole aripiprazole NOUN eurjchem-11 194 23 . . PUNCT eurjchem-11 194 24                                                                                                 SPACE