id	sid	tid	token	lemma	pos
eurjchem-1234	1	1	untitled	untitle	VERB
eurjchem-1234	1	2	european	european	PROPN
eurjchem-1234	1	3	journal	journal	PROPN
eurjchem-1234	1	4	of	of	ADP
eurjchem-1234	1	5	chemistry	chemistry	NOUN
eurjchem-1234	1	6	6	6	NUM
eurjchem-1234	1	7	(	(	PUNCT
eurjchem-1234	1	8	2	2	NUM
eurjchem-1234	1	9	)	)	PUNCT
eurjchem-1234	1	10	(	(	PUNCT
eurjchem-1234	1	11	2015	2015	NUM
eurjchem-1234	1	12	)	)	PUNCT
eurjchem-1234	1	13	178‐182	178‐182	PROPN
eurjchem-1234	1	14	european	european	PROPN
eurjchem-1234	1	15	journal	journal	PROPN
eurjchem-1234	1	16	of	of	ADP
eurjchem-1234	1	17	chemistry	chemistry	NOUN
eurjchem-1234	1	18	issn	issn	PROPN
eurjchem-1234	1	19	2153‐2249	2153‐2249	PROPN
eurjchem-1234	1	20	(	(	PUNCT
eurjchem-1234	1	21	print	print	NOUN
eurjchem-1234	1	22	)	)	PUNCT
eurjchem-1234	1	23	/	/	SYM
eurjchem-1234	1	24	issn	issn	PROPN
eurjchem-1234	1	25	2153‐2257	2153‐2257	NUM
eurjchem-1234	1	26	(	(	PUNCT
eurjchem-1234	1	27	online	online	ADJ
eurjchem-1234	1	28	)	)	PUNCT
eurjchem-1234	1	29			NOUN
eurjchem-1234	1	30	2015	2015	NUM
eurjchem-1234	1	31	atlanta	atlanta	PROPN
eurjchem-1234	1	32	publishing	publishing	PROPN
eurjchem-1234	1	33	house	house	PROPN
eurjchem-1234	1	34	llc	llc	PROPN
eurjchem-1234	1	35	‐	‐	PUNCT
eurjchem-1234	1	36	all	all	DET
eurjchem-1234	1	37	rights	right	NOUN
eurjchem-1234	1	38	reserved	reserve	VERB
eurjchem-1234	1	39	‐	‐	NOUN
eurjchem-1234	1	40	printed	print	VERB
eurjchem-1234	1	41	in	in	ADP
eurjchem-1234	1	42	the	the	DET
eurjchem-1234	1	43	usa	usa	PROPN
eurjchem-1234	1	44	http://dx.doi.org/10.5155/eurjchem.6.2.178‐182.1234	http://dx.doi.org/10.5155/eurjchem.6.2.178‐182.1234	PROPN
eurjchem-1234	1	45	european	european	PROPN
eurjchem-1234	1	46	journal	journal	PROPN
eurjchem-1234	1	47	of	of	ADP
eurjchem-1234	1	48	chemistry	chemistry	PROPN
eurjchem-1234	1	49	journal	journal	PROPN
eurjchem-1234	1	50	webpage	webpage	NOUN
eurjchem-1234	1	51	:	:	PUNCT
eurjchem-1234	1	52	www.eurjchem.com	www.eurjchem.com	X
eurjchem-1234	1	53	determination	determination	NOUN
eurjchem-1234	1	54	of	of	ADP
eurjchem-1234	1	55	metformin	metformin	NOUN
eurjchem-1234	1	56	hydrochloride	hydrochloride	NOUN
eurjchem-1234	1	57	in	in	ADP
eurjchem-1234	1	58	human	human	ADJ
eurjchem-1234	1	59	plasma	plasma	NOUN
eurjchem-1234	1	60	by	by	ADP
eurjchem-1234	1	61	uplc	uplc	PROPN
eurjchem-1234	1	62	/	/	SYM
eurjchem-1234	1	63	ms	ms	PROPN
eurjchem-1234	1	64	/	/	SYM
eurjchem-1234	1	65	ms	ms	PROPN
eurjchem-1234	1	66	:	:	PUNCT
eurjchem-1234	1	67	application	application	NOUN
eurjchem-1234	1	68	in	in	ADP
eurjchem-1234	1	69	bioequivalence	bioequivalence	NOUN
eurjchem-1234	1	70	study	study	NOUN
eurjchem-1234	1	71	samah	samah	PROPN
eurjchem-1234	1	72	abd	abd	PROPN
eurjchem-1234	1	73	elsabour	elsabour	PROPN
eurjchem-1234	1	74	mohammed	mohammed	PROPN
eurjchem-1234	1	75	1	1	NUM
eurjchem-1234	1	76	,	,	PUNCT
eurjchem-1234	1	77	*	*	PUNCT
eurjchem-1234	1	78	,	,	PUNCT
eurjchem-1234	1	79	mohammed	mohammed	PROPN
eurjchem-1234	1	80	el‐dardiri	el‐dardiri	PROPN
eurjchem-1234	1	81	2	2	NUM
eurjchem-1234	1	82	,	,	PUNCT
eurjchem-1234	1	83	mona	mona	PROPN
eurjchem-1234	1	84	ahmed	ahme	VERB
eurjchem-1234	1	85	elhabak	elhabak	PROPN
eurjchem-1234	1	86	2	2	NUM
eurjchem-1234	1	87	and	and	CCONJ
eurjchem-1234	1	88	khaled	khaled	PROPN
eurjchem-1234	1	89	ibrahim	ibrahim	PROPN
eurjchem-1234	1	90	abu	abu	PROPN
eurjchem-1234	1	91	zaid	zaid	PROPN
eurjchem-1234	1	92	2	2	NUM
eurjchem-1234	1	93	1	1	NUM
eurjchem-1234	1	94	national	national	ADJ
eurjchem-1234	1	95	organization	organization	NOUN
eurjchem-1234	1	96	of	of	ADP
eurjchem-1234	1	97	drug	drug	NOUN
eurjchem-1234	1	98	control	control	NOUN
eurjchem-1234	1	99	and	and	CCONJ
eurjchem-1234	1	100	research	research	NOUN
eurjchem-1234	1	101	,	,	PUNCT
eurjchem-1234	1	102	giza	giza	PROPN
eurjchem-1234	1	103	,	,	PUNCT
eurjchem-1234	1	104	11843	11843	NUM
eurjchem-1234	1	105	,	,	PUNCT
eurjchem-1234	1	106	egypt	egypt	PROPN
eurjchem-1234	1	107	2	2	NUM
eurjchem-1234	1	108	bioequivalence	bioequivalence	NOUN
eurjchem-1234	1	109	center	center	NOUN
eurjchem-1234	1	110	,	,	PUNCT
eurjchem-1234	1	111	modern	modern	ADJ
eurjchem-1234	1	112	science	science	NOUN
eurjchem-1234	1	113	and	and	CCONJ
eurjchem-1234	1	114	arts	arts	PROPN
eurjchem-1234	1	115	university	university	PROPN
eurjchem-1234	1	116	,	,	PUNCT
eurjchem-1234	1	117	6th	6th	ADJ
eurjchem-1234	1	118	october	october	PROPN
eurjchem-1234	1	119	,	,	PUNCT
eurjchem-1234	1	120	11787	11787	NUM
eurjchem-1234	1	121	,	,	PUNCT
eurjchem-1234	1	122	egypt	egypt	PROPN
eurjchem-1234	1	123	*	*	PUNCT
eurjchem-1234	1	124	corresponding	correspond	VERB
eurjchem-1234	1	125	author	author	NOUN
eurjchem-1234	1	126	at	at	ADP
eurjchem-1234	1	127	:	:	PUNCT
eurjchem-1234	1	128	national	national	ADJ
eurjchem-1234	1	129	organization	organization	NOUN
eurjchem-1234	1	130	of	of	ADP
eurjchem-1234	1	131	drug	drug	NOUN
eurjchem-1234	1	132	control	control	NOUN
eurjchem-1234	1	133	and	and	CCONJ
eurjchem-1234	1	134	research	research	NOUN
eurjchem-1234	1	135	,	,	PUNCT
eurjchem-1234	1	136	giza	giza	PROPN
eurjchem-1234	1	137	,	,	PUNCT
eurjchem-1234	1	138	11843	11843	NUM
eurjchem-1234	1	139	,	,	PUNCT
eurjchem-1234	1	140	egypt	egypt	PROPN
eurjchem-1234	1	141	.	.	PUNCT
eurjchem-1234	2	1	tel	tel	PROPN
eurjchem-1234	2	2	.	.	PUNCT
eurjchem-1234	2	3	:	:	PUNCT
eurjchem-1234	3	1	+202.02.22599834	+202.02.22599834	PROPN
eurjchem-1234	3	2	.	.	PUNCT
eurjchem-1234	4	1	fax	fax	NOUN
eurjchem-1234	4	2	:	:	PUNCT
eurjchem-1234	4	3	+202.02.37603897	+202.02.37603897	PROPN
eurjchem-1234	4	4	.	.	PUNCT
eurjchem-1234	4	5	e‐mail	e‐mail	PUNCT
eurjchem-1234	5	1	address	address	NOUN
eurjchem-1234	5	2	:	:	PUNCT
eurjchem-1234	5	3	samahsabour@yahoo.com	samahsabour@yahoo.com	X
eurjchem-1234	5	4	(	(	PUNCT
eurjchem-1234	5	5	s.a.e	s.a.e	PROPN
eurjchem-1234	5	6	.	.	PUNCT
eurjchem-1234	5	7	mohammed	mohammed	PROPN
eurjchem-1234	5	8	)	)	PUNCT
eurjchem-1234	5	9	.	.	PUNCT
eurjchem-1234	6	1	article	article	NOUN
eurjchem-1234	6	2	information	information	PROPN
eurjchem-1234	6	3	abstract	abstract	ADJ
eurjchem-1234	6	4	doi	doi	NOUN
eurjchem-1234	6	5	:	:	PUNCT
eurjchem-1234	6	6	10.5155	10.5155	NUM
eurjchem-1234	6	7	/	/	SYM
eurjchem-1234	7	1	eurjchem.6.2.178‐182.1234	eurjchem.6.2.178‐182.1234	NOUN
eurjchem-1234	7	2	received	receive	VERB
eurjchem-1234	7	3	:	:	PUNCT
eurjchem-1234	7	4	24	24	NUM
eurjchem-1234	7	5	december	december	PROPN
eurjchem-1234	7	6	2014	2014	NUM
eurjchem-1234	7	7	received	receive	VERB
eurjchem-1234	7	8	in	in	ADP
eurjchem-1234	7	9	revised	revise	VERB
eurjchem-1234	7	10	form	form	NOUN
eurjchem-1234	7	11	:	:	PUNCT
eurjchem-1234	7	12	14	14	NUM
eurjchem-1234	7	13	february	february	NOUN
eurjchem-1234	7	14	2015	2015	NUM
eurjchem-1234	7	15	accepted	accept	VERB
eurjchem-1234	7	16	:	:	PUNCT
eurjchem-1234	7	17	14	14	NUM
eurjchem-1234	7	18	february	february	NOUN
eurjchem-1234	7	19	2015	2015	NUM
eurjchem-1234	7	20	published	publish	VERB
eurjchem-1234	7	21	online	online	ADV
eurjchem-1234	7	22	:	:	PUNCT
eurjchem-1234	7	23	30	30	NUM
eurjchem-1234	7	24	june	june	PROPN
eurjchem-1234	7	25	2015	2015	NUM
eurjchem-1234	7	26	printed	print	VERB
eurjchem-1234	7	27	:	:	PUNCT
eurjchem-1234	7	28	30	30	NUM
eurjchem-1234	7	29	june	june	PROPN
eurjchem-1234	7	30	2015	2015	NUM
eurjchem-1234	7	31	metformin	metformin	NOUN
eurjchem-1234	7	32	hydrochloride	hydrochloride	NOUN
eurjchem-1234	7	33	was	be	AUX
eurjchem-1234	7	34	quantified	quantify	VERB
eurjchem-1234	7	35	in	in	ADP
eurjchem-1234	7	36	human	human	ADJ
eurjchem-1234	7	37	plasma	plasma	NOUN
eurjchem-1234	7	38	by	by	ADP
eurjchem-1234	7	39	ultra	ultra	ADJ
eurjchem-1234	7	40	performance	performance	NOUN
eurjchem-1234	7	41	liquid	liquid	ADJ
eurjchem-1234	7	42	chromatography	chromatography	NOUN
eurjchem-1234	7	43	with	with	ADP
eurjchem-1234	7	44	tandem	tandem	PROPN
eurjchem-1234	7	45	mass	mass	ADJ
eurjchem-1234	7	46	spectrometric	spectrometric	ADJ
eurjchem-1234	7	47	determination	determination	NOUN
eurjchem-1234	7	48	(	(	PUNCT
eurjchem-1234	7	49	uplc‐ms	uplc‐ms	NOUN
eurjchem-1234	7	50	/	/	SYM
eurjchem-1234	7	51	ms	ms	NOUN
eurjchem-1234	7	52	)	)	PUNCT
eurjchem-1234	7	53	.	.	PUNCT
eurjchem-1234	8	1	the	the	DET
eurjchem-1234	8	2	mobile	mobile	ADJ
eurjchem-1234	8	3	phase	phase	NOUN
eurjchem-1234	8	4	used	use	VERB
eurjchem-1234	8	5	was	be	AUX
eurjchem-1234	8	6	(	(	PUNCT
eurjchem-1234	8	7	water	water	NOUN
eurjchem-1234	8	8	+	+	CCONJ
eurjchem-1234	8	9	0.1	0.1	NUM
eurjchem-1234	8	10	%	%	NOUN
eurjchem-1234	8	11	formic	formic	ADJ
eurjchem-1234	8	12	acid	acid	NOUN
eurjchem-1234	8	13	)	)	PUNCT
eurjchem-1234	8	14	and	and	CCONJ
eurjchem-1234	8	15	(	(	PUNCT
eurjchem-1234	8	16	acetonitrile	acetonitrile	NOUN
eurjchem-1234	8	17	+	+	CCONJ
eurjchem-1234	8	18	0.1	0.1	NUM
eurjchem-1234	8	19	%	%	NOUN
eurjchem-1234	8	20	formic	formic	ADJ
eurjchem-1234	8	21	acid	acid	NOUN
eurjchem-1234	8	22	)	)	PUNCT
eurjchem-1234	8	23	in	in	ADP
eurjchem-1234	8	24	the	the	DET
eurjchem-1234	8	25	ratio	ratio	NOUN
eurjchem-1234	8	26	of	of	ADP
eurjchem-1234	8	27	80:20	80:20	NUM
eurjchem-1234	8	28	(	(	PUNCT
eurjchem-1234	8	29	v	v	NOUN
eurjchem-1234	8	30	:	:	PUNCT
eurjchem-1234	8	31	v	v	NOUN
eurjchem-1234	8	32	)	)	PUNCT
eurjchem-1234	8	33	.	.	PUNCT
eurjchem-1234	9	1	an	an	DET
eurjchem-1234	9	2	acquity	acquity	NOUN
eurjchem-1234	9	3	uplc	uplc	VERB
eurjchem-1234	9	4	hss	hss	PROPN
eurjchem-1234	9	5	t3	t3	PROPN
eurjchem-1234	9	6	1.8	1.8	NUM
eurjchem-1234	9	7	um	um	INTJ
eurjchem-1234	9	8	2.1×50	2.1×50	NUM
eurjchem-1234	9	9	mm	mm	PROPN
eurjchem-1234	9	10	column	column	NOUN
eurjchem-1234	9	11	was	be	AUX
eurjchem-1234	9	12	used	use	VERB
eurjchem-1234	9	13	.	.	PUNCT
eurjchem-1234	10	1	the	the	DET
eurjchem-1234	10	2	detection	detection	NOUN
eurjchem-1234	10	3	was	be	AUX
eurjchem-1234	10	4	performed	perform	VERB
eurjchem-1234	10	5	on	on	ADP
eurjchem-1234	10	6	a	a	DET
eurjchem-1234	10	7	mass	mass	ADJ
eurjchem-1234	10	8	spectrometer	spectrometer	NOUN
eurjchem-1234	10	9	(	(	PUNCT
eurjchem-1234	10	10	esi+	esi+	NOUN
eurjchem-1234	10	11	)	)	PUNCT
eurjchem-1234	10	12	using	use	VERB
eurjchem-1234	10	13	chlorpheniramine	chlorpheniramine	NOUN
eurjchem-1234	10	14	as	as	ADP
eurjchem-1234	10	15	an	an	DET
eurjchem-1234	10	16	internal	internal	ADJ
eurjchem-1234	10	17	standard	standard	NOUN
eurjchem-1234	10	18	.	.	PUNCT
eurjchem-1234	11	1	the	the	DET
eurjchem-1234	11	2	method	method	NOUN
eurjchem-1234	11	3	was	be	AUX
eurjchem-1234	11	4	fully	fully	ADV
eurjchem-1234	11	5	validated	validate	VERB
eurjchem-1234	11	6	and	and	CCONJ
eurjchem-1234	11	7	it	it	PRON
eurjchem-1234	11	8	was	be	AUX
eurjchem-1234	11	9	applied	apply	VERB
eurjchem-1234	11	10	to	to	ADP
eurjchem-1234	11	11	bioequivalence	bioequivalence	NOUN
eurjchem-1234	11	12	study	study	NOUN
eurjchem-1234	11	13	of	of	ADP
eurjchem-1234	11	14	metformin	metformin	NOUN
eurjchem-1234	11	15	hydrochloride	hydrochloride	NOUN
eurjchem-1234	11	16	in	in	ADP
eurjchem-1234	11	17	two	two	NUM
eurjchem-1234	11	18	brands	brand	NOUN
eurjchem-1234	11	19	of	of	ADP
eurjchem-1234	11	20	the	the	DET
eurjchem-1234	11	21	drug	drug	NOUN
eurjchem-1234	11	22	with	with	ADP
eurjchem-1234	11	23	relative	relative	ADJ
eurjchem-1234	11	24	bioequivalence	bioequivalence	NOUN
eurjchem-1234	11	25	of	of	ADP
eurjchem-1234	11	26	94.7	94.7	NUM
eurjchem-1234	11	27	%	%	NOUN
eurjchem-1234	11	28	.	.	PUNCT
eurjchem-1234	12	1	keywords	keyword	VERB
eurjchem-1234	12	2	plasma	plasma	NOUN
eurjchem-1234	12	3	validation	validation	NOUN
eurjchem-1234	12	4	uplc	uplc	ADJ
eurjchem-1234	12	5	/	/	SYM
eurjchem-1234	12	6	ms	ms	PROPN
eurjchem-1234	12	7	/	/	SYM
eurjchem-1234	12	8	ms	ms	PROPN
eurjchem-1234	12	9	bioequivalence	bioequivalence	NOUN
eurjchem-1234	12	10	chlorpheneramine	chlorpheneramine	PROPN
eurjchem-1234	12	11	metformin	metformin	PROPN
eurjchem-1234	12	12	hydrochloride	hydrochloride	NOUN
eurjchem-1234	12	13	cite	cite	VERB
eurjchem-1234	12	14	this	this	PRON
eurjchem-1234	12	15	:	:	PUNCT
eurjchem-1234	12	16	eur	eur	PROPN
eurjchem-1234	12	17	.	.	PUNCT
eurjchem-1234	13	1	j.	j.	PROPN
eurjchem-1234	13	2	chem	chem	PROPN
eurjchem-1234	13	3	.	.	PUNCT
eurjchem-1234	14	1	2015	2015	NUM
eurjchem-1234	14	2	,	,	PUNCT
eurjchem-1234	14	3	6(2	6(2	NUM
eurjchem-1234	14	4	)	)	PUNCT
eurjchem-1234	14	5	,	,	PUNCT
eurjchem-1234	14	6	178‐182	178‐182	NOUN
eurjchem-1234	14	7	1	1	X
eurjchem-1234	14	8	.	.	PUNCT
eurjchem-1234	15	1	introduction	introduction	NOUN
eurjchem-1234	15	2	metformin	metformin	NOUN
eurjchem-1234	15	3	hydrochloride	hydrochloride	NOUN
eurjchem-1234	15	4	is	be	AUX
eurjchem-1234	15	5	n	n	CCONJ
eurjchem-1234	15	6	,	,	PUNCT
eurjchem-1234	15	7	n‐dimethyldiguanide	n‐dimethyldiguanide	X
eurjchem-1234	15	8	hydro	hydro	PROPN
eurjchem-1234	15	9	chloride	chloride	NOUN
eurjchem-1234	15	10	(	(	PUNCT
eurjchem-1234	15	11	figure	figure	NOUN
eurjchem-1234	15	12	1	1	NUM
eurjchem-1234	15	13	)	)	PUNCT
eurjchem-1234	15	14	.	.	PUNCT
eurjchem-1234	16	1	it	it	PRON
eurjchem-1234	16	2	is	be	AUX
eurjchem-1234	16	3	an	an	DET
eurjchem-1234	16	4	inexpensive	inexpensive	ADJ
eurjchem-1234	16	5	biguanide	biguanide	NOUN
eurjchem-1234	16	6	oral	oral	ADJ
eurjchem-1234	16	7	anti	anti	ADJ
eurjchem-1234	16	8	hyperglycemic	hyperglycemic	ADJ
eurjchem-1234	16	9	agent	agent	NOUN
eurjchem-1234	16	10	[	[	X
eurjchem-1234	16	11	1	1	NUM
eurjchem-1234	16	12	]	]	PUNCT
eurjchem-1234	16	13	,	,	PUNCT
eurjchem-1234	16	14	it	it	PRON
eurjchem-1234	16	15	exerts	exert	VERB
eurjchem-1234	16	16	its	its	PRON
eurjchem-1234	16	17	glucose‐lowering	glucose‐lowering	ADJ
eurjchem-1234	16	18	effects	effect	NOUN
eurjchem-1234	16	19	primarily	primarily	ADV
eurjchem-1234	16	20	through	through	ADP
eurjchem-1234	16	21	increased	increase	VERB
eurjchem-1234	16	22	hepatic	hepatic	ADJ
eurjchem-1234	16	23	insulin	insulin	NOUN
eurjchem-1234	16	24	sensitivity	sensitivity	NOUN
eurjchem-1234	16	25	and	and	CCONJ
eurjchem-1234	16	26	the	the	DET
eurjchem-1234	16	27	resultant	resultant	NOUN
eurjchem-1234	16	28	suppression	suppression	NOUN
eurjchem-1234	16	29	of	of	ADP
eurjchem-1234	16	30	hepatic	hepatic	ADJ
eurjchem-1234	16	31	glucose	glucose	NOUN
eurjchem-1234	16	32	output	output	NOUN
eurjchem-1234	16	33	.	.	PUNCT
eurjchem-1234	17	1	metformin	metformin	NOUN
eurjchem-1234	17	2	hydrochloride	hydrochloride	NOUN
eurjchem-1234	17	3	may	may	AUX
eurjchem-1234	17	4	also	also	ADV
eurjchem-1234	17	5	modestly	modestly	ADV
eurjchem-1234	17	6	enhance	enhance	VERB
eurjchem-1234	17	7	glucose	glucose	NOUN
eurjchem-1234	17	8	uptake	uptake	NOUN
eurjchem-1234	17	9	in	in	ADP
eurjchem-1234	17	10	peripheral	peripheral	ADJ
eurjchem-1234	17	11	tissues	tissue	NOUN
eurjchem-1234	17	12	and	and	CCONJ
eurjchem-1234	17	13	increase	increase	VERB
eurjchem-1234	17	14	glucose	glucose	NOUN
eurjchem-1234	17	15	metabolism	metabolism	NOUN
eurjchem-1234	17	16	in	in	ADP
eurjchem-1234	17	17	the	the	DET
eurjchem-1234	17	18	splanchnic	splanchnic	ADJ
eurjchem-1234	17	19	bed	bed	NOUN
eurjchem-1234	18	1	[	[	X
eurjchem-1234	18	2	2	2	NUM
eurjchem-1234	18	3	]	]	PUNCT
eurjchem-1234	18	4	.	.	PUNCT
eurjchem-1234	19	1	it	it	PRON
eurjchem-1234	19	2	is	be	AUX
eurjchem-1234	19	3	also	also	ADV
eurjchem-1234	19	4	used	use	VERB
eurjchem-1234	19	5	for	for	ADP
eurjchem-1234	19	6	diabetes	diabetes	NOUN
eurjchem-1234	19	7	prevention	prevention	NOUN
eurjchem-1234	19	8	,	,	PUNCT
eurjchem-1234	19	9	particularly	particularly	ADV
eurjchem-1234	19	10	in	in	ADP
eurjchem-1234	19	11	overweight	overweight	ADJ
eurjchem-1234	19	12	obese	obese	ADJ
eurjchem-1234	19	13	people	people	NOUN
eurjchem-1234	19	14	and	and	CCONJ
eurjchem-1234	19	15	those	those	PRON
eurjchem-1234	19	16	with	with	ADP
eurjchem-1234	19	17	unimpaired	unimpaired	ADJ
eurjchem-1234	19	18	renal	renal	ADJ
eurjchem-1234	19	19	function	function	NOUN
eurjchem-1234	19	20	[	[	X
eurjchem-1234	19	21	3	3	NUM
eurjchem-1234	19	22	]	]	PUNCT
eurjchem-1234	19	23	.	.	PUNCT
eurjchem-1234	20	1	figure	figure	NOUN
eurjchem-1234	20	2	1	1	NUM
eurjchem-1234	20	3	.	.	PUNCT
eurjchem-1234	21	1	structure	structure	NOUN
eurjchem-1234	21	2	of	of	ADP
eurjchem-1234	21	3	metformin	metformin	NOUN
eurjchem-1234	21	4	hydrochloride	hydrochloride	NOUN
eurjchem-1234	21	5	(	(	PUNCT
eurjchem-1234	21	6	a	a	NOUN
eurjchem-1234	21	7	)	)	PUNCT
eurjchem-1234	21	8	and	and	CCONJ
eurjchem-1234	21	9	chlorpheniramine	chlorpheniramine	PROPN
eurjchem-1234	21	10	(	(	PUNCT
eurjchem-1234	21	11	b	b	NOUN
eurjchem-1234	21	12	)	)	PUNCT
eurjchem-1234	21	13	.	.	PUNCT
eurjchem-1234	22	1	our	our	PRON
eurjchem-1234	22	2	goal	goal	NOUN
eurjchem-1234	22	3	is	be	AUX
eurjchem-1234	22	4	to	to	PART
eurjchem-1234	22	5	develop	develop	VERB
eurjchem-1234	22	6	and	and	CCONJ
eurjchem-1234	22	7	validate	validate	VERB
eurjchem-1234	22	8	a	a	DET
eurjchem-1234	22	9	fast	fast	ADJ
eurjchem-1234	22	10	bio	bio	NOUN
eurjchem-1234	22	11	analytical	analytical	ADJ
eurjchem-1234	22	12	method	method	NOUN
eurjchem-1234	22	13	for	for	ADP
eurjchem-1234	22	14	the	the	DET
eurjchem-1234	22	15	analysis	analysis	NOUN
eurjchem-1234	22	16	of	of	ADP
eurjchem-1234	22	17	metformin	metformin	NOUN
eurjchem-1234	22	18	hydrochloride	hydrochloride	NOUN
eurjchem-1234	22	19	to	to	PART
eurjchem-1234	22	20	support	support	VERB
eurjchem-1234	22	21	bioequivalence	bioequivalence	NOUN
eurjchem-1234	22	22	studies	study	NOUN
eurjchem-1234	22	23	.	.	PUNCT
eurjchem-1234	23	1	direct	direct	ADJ
eurjchem-1234	23	2	injection	injection	NOUN
eurjchem-1234	23	3	of	of	ADP
eurjchem-1234	23	4	the	the	DET
eurjchem-1234	23	5	extracted	extract	VERB
eurjchem-1234	23	6	samples	sample	NOUN
eurjchem-1234	23	7	is	be	AUX
eurjchem-1234	23	8	preferred	prefer	VERB
eurjchem-1234	23	9	.	.	PUNCT
eurjchem-1234	24	1	analysis	analysis	NOUN
eurjchem-1234	24	2	of	of	ADP
eurjchem-1234	24	3	metformin	metformin	NOUN
eurjchem-1234	24	4	hydrochloride	hydrochloride	NOUN
eurjchem-1234	24	5	is	be	AUX
eurjchem-1234	24	6	a	a	DET
eurjchem-1234	24	7	challenge	challenge	NOUN
eurjchem-1234	24	8	owing	owe	VERB
eurjchem-1234	24	9	to	to	ADP
eurjchem-1234	24	10	its	its	PRON
eurjchem-1234	24	11	high	high	ADJ
eurjchem-1234	24	12	polarity	polarity	NOUN
eurjchem-1234	24	13	and	and	CCONJ
eurjchem-1234	24	14	small	small	ADJ
eurjchem-1234	24	15	molecular	molecular	ADJ
eurjchem-1234	24	16	size	size	NOUN
eurjchem-1234	24	17	,	,	PUNCT
eurjchem-1234	24	18	which	which	PRON
eurjchem-1234	24	19	lead	lead	VERB
eurjchem-1234	24	20	to	to	ADP
eurjchem-1234	24	21	poor	poor	ADJ
eurjchem-1234	24	22	retention	retention	NOUN
eurjchem-1234	24	23	of	of	ADP
eurjchem-1234	24	24	metformin	metformin	NOUN
eurjchem-1234	24	25	hydrochloride	hydrochloride	NOUN
eurjchem-1234	24	26	on	on	ADP
eurjchem-1234	24	27	reversed‐phase	reversed‐phase	NOUN
eurjchem-1234	24	28	liquid	liquid	ADJ
eurjchem-1234	24	29	chromatographic	chromatographic	ADJ
eurjchem-1234	24	30	columns	column	NOUN
eurjchem-1234	24	31	.	.	PUNCT
eurjchem-1234	25	1	there	there	PRON
eurjchem-1234	25	2	have	have	AUX
eurjchem-1234	25	3	been	be	AUX
eurjchem-1234	25	4	some	some	DET
eurjchem-1234	25	5	published	publish	VERB
eurjchem-1234	25	6	applications	application	NOUN
eurjchem-1234	25	7	,	,	PUNCT
eurjchem-1234	25	8	which	which	PRON
eurjchem-1234	25	9	used	use	VERB
eurjchem-1234	25	10	reversed‐phase	reversed‐phase	NOUN
eurjchem-1234	25	11	columns	column	NOUN
eurjchem-1234	25	12	such	such	ADJ
eurjchem-1234	25	13	as	as	ADP
eurjchem-1234	25	14	c18	c18	NOUN
eurjchem-1234	25	15	and	and	CCONJ
eurjchem-1234	25	16	c8	c8	PROPN
eurjchem-1234	25	17	.	.	PUNCT
eurjchem-1234	26	1	highly	highly	ADV
eurjchem-1234	26	2	aqueous	aqueous	ADJ
eurjchem-1234	26	3	mobile	mobile	ADJ
eurjchem-1234	26	4	phases	phase	NOUN
eurjchem-1234	26	5	were	be	AUX
eurjchem-1234	26	6	used	use	VERB
eurjchem-1234	26	7	for	for	ADP
eurjchem-1234	26	8	the	the	DET
eurjchem-1234	26	9	analyte	analyte	NOUN
eurjchem-1234	26	10	retention	retention	NOUN
eurjchem-1234	26	11	.	.	PUNCT
eurjchem-1234	27	1	high	high	ADJ
eurjchem-1234	27	2	organic	organic	ADJ
eurjchem-1234	27	3	extracts	extract	NOUN
eurjchem-1234	27	4	are	be	AUX
eurjchem-1234	27	5	not	not	PART
eurjchem-1234	27	6	conducible	conducible	ADJ
eurjchem-1234	27	7	for	for	ADP
eurjchem-1234	27	8	direct	direct	ADJ
eurjchem-1234	27	9	injection	injection	NOUN
eurjchem-1234	27	10	onto	onto	ADP
eurjchem-1234	27	11	reversed	reverse	VERB
eurjchem-1234	27	12	phase	phase	NOUN
eurjchem-1234	27	13	columns	column	NOUN
eurjchem-1234	27	14	with	with	ADP
eurjchem-1234	27	15	highly	highly	ADV
eurjchem-1234	27	16	aqueous	aqueous	ADJ
eurjchem-1234	27	17	mobile	mobile	ADJ
eurjchem-1234	27	18	phases	phase	NOUN
eurjchem-1234	27	19	,	,	PUNCT
eurjchem-1234	27	20	which	which	PRON
eurjchem-1234	27	21	may	may	AUX
eurjchem-1234	27	22	lead	lead	VERB
eurjchem-1234	27	23	to	to	ADP
eurjchem-1234	27	24	poor	poor	ADJ
eurjchem-1234	27	25	chromatograms	chromatogram	NOUN
eurjchem-1234	27	26	with	with	ADP
eurjchem-1234	27	27	peak	peak	NOUN
eurjchem-1234	27	28	broadening	broadening	NOUN
eurjchem-1234	27	29	and	and	CCONJ
eurjchem-1234	27	30	distortion	distortion	NOUN
eurjchem-1234	27	31	[	[	X
eurjchem-1234	27	32	4‐6	4‐6	NOUN
eurjchem-1234	27	33	]	]	PUNCT
eurjchem-1234	27	34	.	.	PUNCT
eurjchem-1234	28	1	therefore	therefore	ADV
eurjchem-1234	28	2	,	,	PUNCT
eurjchem-1234	28	3	many	many	ADJ
eurjchem-1234	28	4	of	of	ADP
eurjchem-1234	28	5	these	these	DET
eurjchem-1234	28	6	applications	application	NOUN
eurjchem-1234	28	7	did	do	AUX
eurjchem-1234	28	8	not	not	PART
eurjchem-1234	28	9	support	support	VERB
eurjchem-1234	28	10	direct	direct	ADJ
eurjchem-1234	28	11	injection	injection	NOUN
eurjchem-1234	28	12	of	of	ADP
eurjchem-1234	28	13	extracted	extract	VERB
eurjchem-1234	28	14	sample	sample	NOUN
eurjchem-1234	28	15	solution	solution	NOUN
eurjchem-1234	28	16	containing	contain	VERB
eurjchem-1234	28	17	high	high	ADJ
eurjchem-1234	28	18	organic	organic	ADJ
eurjchem-1234	28	19	concentration	concentration	NOUN
eurjchem-1234	28	20	,	,	PUNCT
eurjchem-1234	28	21	thus	thus	ADV
eurjchem-1234	28	22	requiring	require	VERB
eurjchem-1234	28	23	additional	additional	ADJ
eurjchem-1234	28	24	time‐consuming	time‐consuming	NOUN
eurjchem-1234	28	25	evaporation	evaporation	NOUN
eurjchem-1234	28	26	and	and	CCONJ
eurjchem-1234	28	27	reconstitution	reconstitution	NOUN
eurjchem-1234	28	28	procedures	procedure	NOUN
eurjchem-1234	28	29	during	during	ADP
eurjchem-1234	28	30	sample	sample	NOUN
eurjchem-1234	28	31	preparation	preparation	NOUN
eurjchem-1234	28	32	.	.	PUNCT
eurjchem-1234	29	1	these	these	DET
eurjchem-1234	29	2	additional	additional	ADJ
eurjchem-1234	29	3	steps	step	NOUN
eurjchem-1234	29	4	could	could	AUX
eurjchem-1234	29	5	also	also	ADV
eurjchem-1234	29	6	lead	lead	VERB
eurjchem-1234	29	7	to	to	ADP
eurjchem-1234	29	8	additional	additional	ADJ
eurjchem-1234	29	9	analyte	analyte	NOUN
eurjchem-1234	29	10	loss	loss	NOUN
eurjchem-1234	29	11	[	[	X
eurjchem-1234	29	12	7‐11	7‐11	X
eurjchem-1234	29	13	]	]	PUNCT
eurjchem-1234	29	14	.	.	PUNCT
eurjchem-1234	30	1	using	use	VERB
eurjchem-1234	30	2	of	of	ADP
eurjchem-1234	30	3	solid	solid	ADJ
eurjchem-1234	30	4	phase	phase	NOUN
eurjchem-1234	30	5	extraction	extraction	NOUN
eurjchem-1234	30	6	increases	increase	VERB
eurjchem-1234	30	7	the	the	DET
eurjchem-1234	30	8	coast	coast	NOUN
eurjchem-1234	30	9	of	of	ADP
eurjchem-1234	30	10	the	the	DET
eurjchem-1234	30	11	method	method	NOUN
eurjchem-1234	30	12	to	to	PART
eurjchem-1234	30	13	be	be	AUX
eurjchem-1234	30	14	applicable	applicable	ADJ
eurjchem-1234	30	15	for	for	ADP
eurjchem-1234	30	16	analysis	analysis	NOUN
eurjchem-1234	30	17	large	large	ADJ
eurjchem-1234	30	18	number	number	NOUN
eurjchem-1234	30	19	of	of	ADP
eurjchem-1234	30	20	samples	sample	NOUN
eurjchem-1234	30	21	in	in	ADP
eurjchem-1234	30	22	bioequivalence	bioequivalence	NOUN
eurjchem-1234	30	23	studies	study	NOUN
eurjchem-1234	30	24	[	[	X
eurjchem-1234	30	25	12	12	NUM
eurjchem-1234	30	26	]	]	PUNCT
eurjchem-1234	30	27	.	.	PUNCT
eurjchem-1234	31	1	only	only	ADV
eurjchem-1234	31	2	one	one	NUM
eurjchem-1234	31	3	method	method	NOUN
eurjchem-1234	31	4	was	be	AUX
eurjchem-1234	31	5	published	publish	VERB
eurjchem-1234	31	6	for	for	ADP
eurjchem-1234	31	7	direct	direct	ADJ
eurjchem-1234	31	8	injection	injection	NOUN
eurjchem-1234	31	9	using	use	VERB
eurjchem-1234	31	10	mohammed	mohammed	PROPN
eurjchem-1234	31	11	et	et	PROPN
eurjchem-1234	31	12	al	al	PROPN
eurjchem-1234	31	13	.	.	PUNCT
eurjchem-1234	31	14	/	/	SYM
eurjchem-1234	31	15	european	european	PROPN
eurjchem-1234	31	16	journal	journal	PROPN
eurjchem-1234	31	17	of	of	ADP
eurjchem-1234	31	18	chemistry	chemistry	NOUN
eurjchem-1234	31	19	6	6	NUM
eurjchem-1234	31	20	(	(	PUNCT
eurjchem-1234	31	21	2	2	NUM
eurjchem-1234	31	22	)	)	PUNCT
eurjchem-1234	31	23	(	(	PUNCT
eurjchem-1234	31	24	2015	2015	NUM
eurjchem-1234	31	25	)	)	PUNCT
eurjchem-1234	31	26	178‐182	178‐182	NOUN
eurjchem-1234	31	27	179	179	NUM
eurjchem-1234	31	28	hydrophilic	hydrophilic	ADJ
eurjchem-1234	31	29	interaction	interaction	NOUN
eurjchem-1234	31	30	liquid	liquid	ADJ
eurjchem-1234	31	31	chromatography	chromatography	NOUN
eurjchem-1234	31	32	tandem	tandem	PROPN
eurjchem-1234	31	33	mass	mass	PROPN
eurjchem-1234	31	34	spectrometry	spectrometry	NOUN
eurjchem-1234	31	35	(	(	PUNCT
eurjchem-1234	31	36	hilic‐ms	hilic‐ms	NUM
eurjchem-1234	31	37	/	/	SYM
eurjchem-1234	31	38	ms	ms	NOUN
eurjchem-1234	31	39	)	)	PUNCT
eurjchem-1234	32	1	[	[	X
eurjchem-1234	32	2	13	13	NUM
eurjchem-1234	32	3	]	]	PUNCT
eurjchem-1234	32	4	.	.	PUNCT
eurjchem-1234	33	1	the	the	DET
eurjchem-1234	33	2	present	present	ADJ
eurjchem-1234	33	3	paper	paper	NOUN
eurjchem-1234	33	4	describes	describe	VERB
eurjchem-1234	33	5	a	a	DET
eurjchem-1234	33	6	fast	fast	ADJ
eurjchem-1234	33	7	and	and	CCONJ
eurjchem-1234	33	8	highly	highly	ADV
eurjchem-1234	33	9	sensitive	sensitive	ADJ
eurjchem-1234	33	10	approach	approach	NOUN
eurjchem-1234	33	11	that	that	PRON
eurjchem-1234	33	12	enables	enable	VERB
eurjchem-1234	33	13	the	the	DET
eurjchem-1234	33	14	determination	determination	NOUN
eurjchem-1234	33	15	of	of	ADP
eurjchem-1234	33	16	metformin	metformin	NOUN
eurjchem-1234	33	17	hydrochloride	hydrochloride	NOUN
eurjchem-1234	33	18	at	at	ADP
eurjchem-1234	33	19	0.20	0.20	NUM
eurjchem-1234	33	20	min	min	NOUN
eurjchem-1234	33	21	with	with	ADP
eurjchem-1234	33	22	a	a	DET
eurjchem-1234	33	23	total	total	ADJ
eurjchem-1234	33	24	analysis	analysis	NOUN
eurjchem-1234	33	25	time	time	NOUN
eurjchem-1234	33	26	of	of	ADP
eurjchem-1234	33	27	0.5	0.5	NUM
eurjchem-1234	33	28	min	min	NOUN
eurjchem-1234	33	29	.	.	NOUN
eurjchem-1234	33	30	using	use	VERB
eurjchem-1234	33	31	acquity	acquity	NOUN
eurjchem-1234	33	32	uplc	uplc	VERB
eurjchem-1234	33	33	hss	hss	PROPN
eurjchem-1234	33	34	t3	t3	PROPN
eurjchem-1234	33	35	column	column	PROPN
eurjchem-1234	33	36	,	,	PUNCT
eurjchem-1234	33	37	which	which	PRON
eurjchem-1234	33	38	is	be	AUX
eurjchem-1234	33	39	suitable	suitable	ADJ
eurjchem-1234	33	40	for	for	ADP
eurjchem-1234	33	41	analysis	analysis	NOUN
eurjchem-1234	33	42	of	of	ADP
eurjchem-1234	33	43	highly	highly	ADV
eurjchem-1234	33	44	organic	organic	ADJ
eurjchem-1234	33	45	samples	sample	NOUN
eurjchem-1234	33	46	with	with	ADP
eurjchem-1234	33	47	direct	direct	ADJ
eurjchem-1234	33	48	injection	injection	NOUN
eurjchem-1234	33	49	.	.	PUNCT
eurjchem-1234	34	1	this	this	DET
eurjchem-1234	34	2	method	method	NOUN
eurjchem-1234	34	3	was	be	AUX
eurjchem-1234	34	4	fully	fully	ADV
eurjchem-1234	34	5	validated	validate	VERB
eurjchem-1234	34	6	and	and	CCONJ
eurjchem-1234	34	7	it	it	PRON
eurjchem-1234	34	8	was	be	AUX
eurjchem-1234	34	9	applied	apply	VERB
eurjchem-1234	34	10	to	to	ADP
eurjchem-1234	34	11	bioequivalence	bioequivalence	NOUN
eurjchem-1234	34	12	study	study	NOUN
eurjchem-1234	34	13	of	of	ADP
eurjchem-1234	34	14	two	two	NUM
eurjchem-1234	34	15	brands	brand	NOUN
eurjchem-1234	34	16	of	of	ADP
eurjchem-1234	34	17	the	the	DET
eurjchem-1234	34	18	drug	drug	NOUN
eurjchem-1234	34	19	.	.	PUNCT
eurjchem-1234	35	1	2	2	X
eurjchem-1234	35	2	.	.	X
eurjchem-1234	35	3	experimental	experimental	ADJ
eurjchem-1234	35	4	2.1	2.1	NUM
eurjchem-1234	35	5	.	.	PUNCT
eurjchem-1234	36	1	materials	material	NOUN
eurjchem-1234	36	2	metformin	metformin	NOUN
eurjchem-1234	36	3	hydrochloride	hydrochloride	NOUN
eurjchem-1234	36	4	and	and	CCONJ
eurjchem-1234	36	5	chlorpheniramine	chlorpheniramine	PROPN
eurjchem-1234	36	6	(	(	PUNCT
eurjchem-1234	36	7	internal	internal	ADJ
eurjchem-1234	36	8	standard	standard	NOUN
eurjchem-1234	36	9	,	,	PUNCT
eurjchem-1234	36	10	is	be	AUX
eurjchem-1234	36	11	)	)	PUNCT
eurjchem-1234	36	12	were	be	AUX
eurjchem-1234	36	13	purchased	purchase	VERB
eurjchem-1234	36	14	from	from	ADP
eurjchem-1234	36	15	sigma	sigma	PROPN
eurjchem-1234	36	16	aldrich	aldrich	PROPN
eurjchem-1234	36	17	,	,	PUNCT
eurjchem-1234	36	18	usa	usa	PROPN
eurjchem-1234	36	19	,	,	PUNCT
eurjchem-1234	36	20	the	the	DET
eurjchem-1234	36	21	chemical	chemical	NOUN
eurjchem-1234	36	22	structures	structure	NOUN
eurjchem-1234	36	23	of	of	ADP
eurjchem-1234	36	24	metformin	metformin	NOUN
eurjchem-1234	36	25	hydrochloride	hydrochloride	NOUN
eurjchem-1234	36	26	and	and	CCONJ
eurjchem-1234	36	27	is	be	AUX
eurjchem-1234	36	28	are	be	AUX
eurjchem-1234	36	29	shown	show	VERB
eurjchem-1234	36	30	in	in	ADP
eurjchem-1234	36	31	figure	figure	NOUN
eurjchem-1234	36	32	1	1	NUM
eurjchem-1234	36	33	.	.	PUNCT
eurjchem-1234	37	1	acetonitrile	acetonitrile	NOUN
eurjchem-1234	37	2	of	of	ADP
eurjchem-1234	37	3	hplc	hplc	PROPN
eurjchem-1234	37	4	grade	grade	NOUN
eurjchem-1234	37	5	was	be	AUX
eurjchem-1234	37	6	purchased	purchase	VERB
eurjchem-1234	37	7	from	from	ADP
eurjchem-1234	37	8	e.	e.	PROPN
eurjchem-1234	37	9	merck	merck	PROPN
eurjchem-1234	37	10	,	,	PUNCT
eurjchem-1234	37	11	darmstadt	darmstadt	PROPN
eurjchem-1234	37	12	,	,	PUNCT
eurjchem-1234	37	13	germany	germany	PROPN
eurjchem-1234	37	14	.	.	PUNCT
eurjchem-1234	38	1	formic	formic	PROPN
eurjchem-1234	38	2	acid	acid	PROPN
eurjchem-1234	38	3	was	be	AUX
eurjchem-1234	38	4	purchased	purchase	VERB
eurjchem-1234	38	5	from	from	ADP
eurjchem-1234	38	6	sigma	sigma	PROPN
eurjchem-1234	38	7	aldrich	aldrich	PROPN
eurjchem-1234	38	8	,	,	PUNCT
eurjchem-1234	38	9	usa	usa	PROPN
eurjchem-1234	38	10	.	.	PROPN
eurjchem-1234	38	11	purified	purified	ADJ
eurjchem-1234	38	12	water	water	NOUN
eurjchem-1234	38	13	was	be	AUX
eurjchem-1234	38	14	processed	process	VERB
eurjchem-1234	38	15	using	use	VERB
eurjchem-1234	38	16	an	an	DET
eurjchem-1234	38	17	elga	elga	ADJ
eurjchem-1234	38	18	pure	pure	ADJ
eurjchem-1234	38	19	lab	lab	NOUN
eurjchem-1234	38	20	classic	classic	ADJ
eurjchem-1234	38	21	water	water	NOUN
eurjchem-1234	38	22	polisher	polisher	NOUN
eurjchem-1234	38	23	and	and	CCONJ
eurjchem-1234	38	24	deionizing	deionize	VERB
eurjchem-1234	38	25	unit	unit	NOUN
eurjchem-1234	38	26	(	(	PUNCT
eurjchem-1234	38	27	marlow	marlow	PROPN
eurjchem-1234	38	28	,	,	PUNCT
eurjchem-1234	38	29	uk	uk	PROPN
eurjchem-1234	38	30	)	)	PUNCT
eurjchem-1234	38	31	.	.	PUNCT
eurjchem-1234	39	1	blank	blank	ADJ
eurjchem-1234	39	2	human	human	ADJ
eurjchem-1234	39	3	plasma	plasma	NOUN
eurjchem-1234	39	4	was	be	AUX
eurjchem-1234	39	5	purchased	purchase	VERB
eurjchem-1234	39	6	from	from	ADP
eurjchem-1234	39	7	vacsera	vacsera	PROPN
eurjchem-1234	39	8	,	,	PUNCT
eurjchem-1234	39	9	giza	giza	PROPN
eurjchem-1234	39	10	,	,	PUNCT
eurjchem-1234	39	11	egypt	egypt	PROPN
eurjchem-1234	39	12	and	and	CCONJ
eurjchem-1234	39	13	was	be	AUX
eurjchem-1234	39	14	stored	store	VERB
eurjchem-1234	39	15	frozen	frozen	ADJ
eurjchem-1234	39	16	at	at	ADP
eurjchem-1234	39	17	‐70	‐70	PROPN
eurjchem-1234	39	18	°	°	ADP
eurjchem-1234	39	19	c	c	NOUN
eurjchem-1234	39	20	.	.	PUNCT
eurjchem-1234	40	1	all	all	DET
eurjchem-1234	40	2	mobile	mobile	ADJ
eurjchem-1234	40	3	phase	phase	NOUN
eurjchem-1234	40	4	solvents	solvent	NOUN
eurjchem-1234	40	5	were	be	AUX
eurjchem-1234	40	6	hplc	hplc	NOUN
eurjchem-1234	40	7	grade	grade	NOUN
eurjchem-1234	40	8	and	and	CCONJ
eurjchem-1234	40	9	were	be	AUX
eurjchem-1234	40	10	filtered	filter	VERB
eurjchem-1234	40	11	through	through	ADP
eurjchem-1234	40	12	0.22	0.22	NUM
eurjchem-1234	40	13	μm	μm	NOUN
eurjchem-1234	40	14	filters	filter	NOUN
eurjchem-1234	40	15	(	(	PUNCT
eurjchem-1234	40	16	hnwp	hnwp	ADJ
eurjchem-1234	40	17	membrane	membrane	NOUN
eurjchem-1234	40	18	filters	filter	NOUN
eurjchem-1234	40	19	,	,	PUNCT
eurjchem-1234	40	20	millipore	millipore	PROPN
eurjchem-1234	40	21	)	)	PUNCT
eurjchem-1234	40	22	.	.	PUNCT
eurjchem-1234	41	1	2.2	2.2	NUM
eurjchem-1234	41	2	.	.	PUNCT
eurjchem-1234	41	3	instrumentations	instrumentation	NOUN
eurjchem-1234	41	4	and	and	CCONJ
eurjchem-1234	41	5	chromatographic	chromatographic	ADJ
eurjchem-1234	41	6	conditions	condition	NOUN
eurjchem-1234	41	7	2.2.1	2.2.1	NUM
eurjchem-1234	41	8	.	.	PUNCT
eurjchem-1234	41	9	liquid	liquid	ADJ
eurjchem-1234	41	10	chromatography	chromatography	NOUN
eurjchem-1234	41	11	chromatographic	chromatographic	ADJ
eurjchem-1234	41	12	separation	separation	NOUN
eurjchem-1234	41	13	was	be	AUX
eurjchem-1234	41	14	performed	perform	VERB
eurjchem-1234	41	15	on	on	ADP
eurjchem-1234	41	16	waters	water	NOUN
eurjchem-1234	41	17	uplc	uplc	ADJ
eurjchem-1234	41	18	system	system	NOUN
eurjchem-1234	41	19	(	(	PUNCT
eurjchem-1234	41	20	milford	milford	NOUN
eurjchem-1234	41	21	,	,	PUNCT
eurjchem-1234	41	22	massachusetts	massachusetts	PROPN
eurjchem-1234	41	23	,	,	PUNCT
eurjchem-1234	41	24	usa	usa	PROPN
eurjchem-1234	41	25	)	)	PUNCT
eurjchem-1234	41	26	with	with	ADP
eurjchem-1234	41	27	an	an	DET
eurjchem-1234	41	28	auto	auto	NOUN
eurjchem-1234	41	29	sampler	sampler	NOUN
eurjchem-1234	41	30	and	and	CCONJ
eurjchem-1234	41	31	a	a	DET
eurjchem-1234	41	32	column	column	NOUN
eurjchem-1234	41	33	oven	oven	NOUN
eurjchem-1234	41	34	that	that	PRON
eurjchem-1234	41	35	enabled	enable	VERB
eurjchem-1234	41	36	temperature	temperature	NOUN
eurjchem-1234	41	37	control	control	NOUN
eurjchem-1234	41	38	of	of	ADP
eurjchem-1234	41	39	the	the	DET
eurjchem-1234	41	40	analytical	analytical	ADJ
eurjchem-1234	41	41	column	column	NOUN
eurjchem-1234	41	42	.	.	PUNCT
eurjchem-1234	42	1	acquity	acquity	NOUN
eurjchem-1234	42	2	uplc	uplc	VERB
eurjchem-1234	42	3	hss	hss	PROPN
eurjchem-1234	42	4	t3	t3	PROPN
eurjchem-1234	42	5	1.8	1.8	NUM
eurjchem-1234	42	6	µm	µm	NUM
eurjchem-1234	42	7	2.1×50	2.1×50	NUM
eurjchem-1234	42	8	mm	mm	PROPN
eurjchem-1234	42	9	column	column	NOUN
eurjchem-1234	42	10	was	be	AUX
eurjchem-1234	42	11	employed	employ	VERB
eurjchem-1234	42	12	and	and	CCONJ
eurjchem-1234	42	13	maintained	maintain	VERB
eurjchem-1234	42	14	at	at	ADP
eurjchem-1234	42	15	40	40	NUM
eurjchem-1234	42	16	°	°	NOUN
eurjchem-1234	42	17	c	c	NOUN
eurjchem-1234	42	18	.	.	PUNCT
eurjchem-1234	43	1	the	the	DET
eurjchem-1234	43	2	mobile	mobile	ADJ
eurjchem-1234	43	3	phase	phase	NOUN
eurjchem-1234	43	4	consisted	consist	VERB
eurjchem-1234	43	5	of	of	ADP
eurjchem-1234	43	6	(	(	PUNCT
eurjchem-1234	43	7	water	water	NOUN
eurjchem-1234	43	8	+	+	CCONJ
eurjchem-1234	43	9	0.1	0.1	NUM
eurjchem-1234	43	10	%	%	NOUN
eurjchem-1234	43	11	formic	formic	NOUN
eurjchem-1234	43	12	acid):(acetonitril	acid):(acetonitril	PROPN
eurjchem-1234	43	13	+	+	SYM
eurjchem-1234	43	14	0.1	0.1	NUM
eurjchem-1234	43	15	%	%	NOUN
eurjchem-1234	43	16	formic	formic	ADJ
eurjchem-1234	43	17	acid	acid	NOUN
eurjchem-1234	43	18	)	)	PUNCT
eurjchem-1234	43	19	in	in	ADP
eurjchem-1234	43	20	the	the	DET
eurjchem-1234	43	21	ratio	ratio	NOUN
eurjchem-1234	43	22	of	of	ADP
eurjchem-1234	43	23	80:20	80:20	NUM
eurjchem-1234	43	24	(	(	PUNCT
eurjchem-1234	43	25	v	v	NOUN
eurjchem-1234	43	26	:	:	PUNCT
eurjchem-1234	43	27	v	v	NOUN
eurjchem-1234	43	28	)	)	PUNCT
eurjchem-1234	43	29	at	at	ADP
eurjchem-1234	43	30	an	an	DET
eurjchem-1234	43	31	isocratic	isocratic	ADJ
eurjchem-1234	43	32	flow	flow	NOUN
eurjchem-1234	43	33	rate	rate	NOUN
eurjchem-1234	43	34	of	of	ADP
eurjchem-1234	43	35	0.65	0.65	NUM
eurjchem-1234	43	36	ml	ml	NOUN
eurjchem-1234	43	37	/	/	SYM
eurjchem-1234	43	38	min	min	NOUN
eurjchem-1234	43	39	.	.	PUNCT
eurjchem-1234	44	1	the	the	DET
eurjchem-1234	44	2	injection	injection	NOUN
eurjchem-1234	44	3	volume	volume	NOUN
eurjchem-1234	44	4	was	be	AUX
eurjchem-1234	44	5	10	10	NUM
eurjchem-1234	44	6	μl	μl	NOUN
eurjchem-1234	44	7	.	.	PUNCT
eurjchem-1234	45	1	2.2.2	2.2.2	X
eurjchem-1234	45	2	.	.	PUNCT
eurjchem-1234	45	3	mass	mass	ADJ
eurjchem-1234	45	4	spectrometry	spectrometry	NOUN
eurjchem-1234	45	5	waters	water	NOUN
eurjchem-1234	45	6	uplc	uplc	VERB
eurjchem-1234	45	7	xevo	xevo	PROPN
eurjchem-1234	45	8	tqd	tqd	PROPN
eurjchem-1234	45	9	system	system	NOUN
eurjchem-1234	45	10	(	(	PUNCT
eurjchem-1234	45	11	milford	milford	NOUN
eurjchem-1234	45	12	,	,	PUNCT
eurjchem-1234	45	13	massachusetts	massachusetts	PROPN
eurjchem-1234	45	14	,	,	PUNCT
eurjchem-1234	45	15	usa	usa	PROPN
eurjchem-1234	45	16	)	)	PUNCT
eurjchem-1234	45	17	equipped	equip	VERB
eurjchem-1234	45	18	with	with	ADP
eurjchem-1234	45	19	a	a	DET
eurjchem-1234	45	20	turbo	turbo	NOUN
eurjchem-1234	45	21	ion	ion	NOUN
eurjchem-1234	45	22	spray	spray	NOUN
eurjchem-1234	45	23	interface	interface	NOUN
eurjchem-1234	45	24	.	.	PUNCT
eurjchem-1234	46	1	mass	mass	ADJ
eurjchem-1234	46	2	spectrometer	spectrometer	NOUN
eurjchem-1234	46	3	settings	setting	NOUN
eurjchem-1234	46	4	in	in	ADP
eurjchem-1234	46	5	positive‐ion	positive‐ion	NOUN
eurjchem-1234	46	6	mode	mode	NOUN
eurjchem-1234	46	7	(	(	PUNCT
eurjchem-1234	46	8	esi+	esi+	NOUN
eurjchem-1234	46	9	)	)	PUNCT
eurjchem-1234	46	10	with	with	ADP
eurjchem-1234	46	11	ion	ion	NOUN
eurjchem-1234	46	12	spray	spray	NOUN
eurjchem-1234	46	13	voltage	voltage	NOUN
eurjchem-1234	46	14	at	at	ADP
eurjchem-1234	46	15	5000	5000	NUM
eurjchem-1234	46	16	v	v	NOUN
eurjchem-1234	46	17	,	,	PUNCT
eurjchem-1234	46	18	temperature	temperature	NOUN
eurjchem-1234	46	19	at	at	ADP
eurjchem-1234	46	20	400	400	NUM
eurjchem-1234	46	21	°	°	NOUN
eurjchem-1234	46	22	c	c	NOUN
eurjchem-1234	46	23	,	,	PUNCT
eurjchem-1234	46	24	collision	collision	NOUN
eurjchem-1234	46	25	gas	gas	NOUN
eurjchem-1234	46	26	(	(	PUNCT
eurjchem-1234	46	27	n2	n2	NOUN
eurjchem-1234	46	28	)	)	PUNCT
eurjchem-1234	46	29	at	at	ADP
eurjchem-1234	46	30	15	15	NUM
eurjchem-1234	46	31	psi	psi	NOUN
eurjchem-1234	46	32	,	,	PUNCT
eurjchem-1234	46	33	curtain	curtain	NOUN
eurjchem-1234	46	34	gas	gas	NOUN
eurjchem-1234	46	35	at	at	ADP
eurjchem-1234	46	36	20	20	NUM
eurjchem-1234	46	37	psi	psi	NOUN
eurjchem-1234	46	38	,	,	PUNCT
eurjchem-1234	46	39	declustering	declustere	VERB
eurjchem-1234	46	40	potential	potential	ADJ
eurjchem-1234	46	41	(	(	PUNCT
eurjchem-1234	46	42	dp	dp	NOUN
eurjchem-1234	46	43	)	)	PUNCT
eurjchem-1234	46	44	and	and	CCONJ
eurjchem-1234	46	45	collision	collision	VERB
eurjchem-1234	46	46	energy	energy	NOUN
eurjchem-1234	46	47	(	(	PUNCT
eurjchem-1234	46	48	ce	ce	PROPN
eurjchem-1234	46	49	)	)	PUNCT
eurjchem-1234	46	50	were	be	AUX
eurjchem-1234	46	51	set	set	VERB
eurjchem-1234	46	52	at	at	ADP
eurjchem-1234	46	53	40	40	NUM
eurjchem-1234	46	54	and	and	CCONJ
eurjchem-1234	46	55	60	60	NUM
eurjchem-1234	46	56	.	.	PUNCT
eurjchem-1234	47	1	quantification	quantification	NOUN
eurjchem-1234	47	2	was	be	AUX
eurjchem-1234	47	3	performed	perform	VERB
eurjchem-1234	47	4	using	use	VERB
eurjchem-1234	47	5	multiple	multiple	ADJ
eurjchem-1234	47	6	reaction	reaction	NOUN
eurjchem-1234	47	7	monitoring	monitoring	NOUN
eurjchem-1234	47	8	(	(	PUNCT
eurjchem-1234	47	9	mrm	mrm	PROPN
eurjchem-1234	47	10	)	)	PUNCT
eurjchem-1234	47	11	of	of	ADP
eurjchem-1234	47	12	the	the	DET
eurjchem-1234	47	13	transitions	transition	NOUN
eurjchem-1234	47	14	of	of	ADP
eurjchem-1234	47	15	(	(	PUNCT
eurjchem-1234	47	16	precursor	precursor	NOUN
eurjchem-1234	47	17	to	to	ADP
eurjchem-1234	47	18	product	product	NOUN
eurjchem-1234	47	19	)	)	PUNCT
eurjchem-1234	47	20	monitored	monitor	VERB
eurjchem-1234	47	21	were	be	AUX
eurjchem-1234	47	22	m	m	PROPN
eurjchem-1234	47	23	/	/	SYM
eurjchem-1234	47	24	z	z	PROPN
eurjchem-1234	47	25	129.93/59.99	129.93/59.99	PROPN
eurjchem-1234	47	26	for	for	ADP
eurjchem-1234	47	27	metformin	metformin	NOUN
eurjchem-1234	47	28	hydrochloride	hydrochloride	NOUN
eurjchem-1234	47	29	and	and	CCONJ
eurjchem-1234	47	30	m	m	PROPN
eurjchem-1234	47	31	/	/	SYM
eurjchem-1234	47	32	z	z	PROPN
eurjchem-1234	47	33	275.14/229.93	275.14/229.93	PROPN
eurjchem-1234	47	34	for	for	ADP
eurjchem-1234	47	35	chlorpheniramine	chlorpheniramine	NOUN
eurjchem-1234	47	36	.	.	PUNCT
eurjchem-1234	48	1	data	datum	NOUN
eurjchem-1234	48	2	acquisition	acquisition	NOUN
eurjchem-1234	48	3	and	and	CCONJ
eurjchem-1234	48	4	processing	processing	NOUN
eurjchem-1234	48	5	were	be	AUX
eurjchem-1234	48	6	performed	perform	VERB
eurjchem-1234	48	7	with	with	ADP
eurjchem-1234	48	8	the	the	DET
eurjchem-1234	48	9	analyst	analyst	NOUN
eurjchem-1234	48	10	software	software	NOUN
eurjchem-1234	48	11	.	.	PUNCT
eurjchem-1234	49	1	2.3	2.3	NUM
eurjchem-1234	49	2	.	.	PUNCT
eurjchem-1234	49	3	calibration	calibration	NOUN
eurjchem-1234	49	4	standards	standard	NOUN
eurjchem-1234	49	5	and	and	CCONJ
eurjchem-1234	49	6	quality	quality	NOUN
eurjchem-1234	49	7	control	control	NOUN
eurjchem-1234	49	8	samples	sample	NOUN
eurjchem-1234	49	9	standards	standard	NOUN
eurjchem-1234	49	10	and	and	CCONJ
eurjchem-1234	49	11	quality	quality	NOUN
eurjchem-1234	49	12	control	control	NOUN
eurjchem-1234	49	13	samples	sample	NOUN
eurjchem-1234	49	14	(	(	PUNCT
eurjchem-1234	49	15	qcs	qcs	NOUN
eurjchem-1234	49	16	)	)	PUNCT
eurjchem-1234	49	17	of	of	ADP
eurjchem-1234	49	18	metformin	metformin	NOUN
eurjchem-1234	49	19	hydrochloride	hydrochloride	NOUN
eurjchem-1234	49	20	were	be	AUX
eurjchem-1234	49	21	prepared	prepare	VERB
eurjchem-1234	49	22	from	from	ADP
eurjchem-1234	49	23	stock	stock	NOUN
eurjchem-1234	49	24	solutions	solution	NOUN
eurjchem-1234	49	25	(	(	PUNCT
eurjchem-1234	49	26	5	5	NUM
eurjchem-1234	49	27	µg	µg	ADV
eurjchem-1234	49	28	/	/	SYM
eurjchem-1234	49	29	ml	ml	NOUN
eurjchem-1234	49	30	in	in	ADP
eurjchem-1234	49	31	water	water	NOUN
eurjchem-1234	49	32	)	)	PUNCT
eurjchem-1234	49	33	.	.	PUNCT
eurjchem-1234	50	1	working	work	VERB
eurjchem-1234	50	2	calibration	calibration	NOUN
eurjchem-1234	50	3	standards	standard	NOUN
eurjchem-1234	50	4	at	at	ADP
eurjchem-1234	50	5	concentrations	concentration	NOUN
eurjchem-1234	50	6	of	of	ADP
eurjchem-1234	50	7	5.00	5.00	NUM
eurjchem-1234	50	8	,	,	PUNCT
eurjchem-1234	50	9	25.00	25.00	NUM
eurjchem-1234	50	10	,	,	PUNCT
eurjchem-1234	50	11	50.00	50.00	NUM
eurjchem-1234	50	12	,	,	PUNCT
eurjchem-1234	50	13	100.00	100.00	NUM
eurjchem-1234	50	14	,	,	PUNCT
eurjchem-1234	50	15	500.00	500.00	NUM
eurjchem-1234	50	16	,	,	PUNCT
eurjchem-1234	50	17	1000.00	1000.00	NUM
eurjchem-1234	50	18	,	,	PUNCT
eurjchem-1234	50	19	2000.00	2000.00	NUM
eurjchem-1234	50	20	,	,	PUNCT
eurjchem-1234	50	21	3000.00	3000.00	NUM
eurjchem-1234	50	22	and	and	CCONJ
eurjchem-1234	50	23	4000.00	4000.00	NUM
eurjchem-1234	50	24	ng	ng	NOUN
eurjchem-1234	50	25	/	/	SYM
eurjchem-1234	50	26	ml	ml	NOUN
eurjchem-1234	50	27	were	be	AUX
eurjchem-1234	50	28	prepared	prepare	VERB
eurjchem-1234	50	29	in	in	ADP
eurjchem-1234	50	30	blank	blank	ADJ
eurjchem-1234	50	31	plasma	plasma	NOUN
eurjchem-1234	50	32	.	.	PUNCT
eurjchem-1234	51	1	chlorpheniramine	chlorpheniramine	PROPN
eurjchem-1234	51	2	was	be	AUX
eurjchem-1234	51	3	prepared	prepare	VERB
eurjchem-1234	51	4	in	in	ADP
eurjchem-1234	51	5	water	water	NOUN
eurjchem-1234	51	6	with	with	ADP
eurjchem-1234	51	7	concentration	concentration	NOUN
eurjchem-1234	51	8	of	of	ADP
eurjchem-1234	51	9	50.00	50.00	NUM
eurjchem-1234	51	10	µg	µg	NOUN
eurjchem-1234	51	11	/	/	SYM
eurjchem-1234	51	12	ml	ml	NOUN
eurjchem-1234	51	13	.	.	PUNCT
eurjchem-1234	52	1	three	three	NUM
eurjchem-1234	52	2	levels	level	NOUN
eurjchem-1234	52	3	of	of	ADP
eurjchem-1234	52	4	qc	qc	PROPN
eurjchem-1234	52	5	samples	sample	NOUN
eurjchem-1234	52	6	at	at	ADP
eurjchem-1234	52	7	10.00	10.00	NUM
eurjchem-1234	52	8	,	,	PUNCT
eurjchem-1234	52	9	2000	2000	NUM
eurjchem-1234	52	10	and	and	CCONJ
eurjchem-1234	52	11	3000.00	3000.00	NUM
eurjchem-1234	52	12	ng	ng	NOUN
eurjchem-1234	52	13	/	/	SYM
eurjchem-1234	52	14	ml	ml	PROPN
eurjchem-1234	52	15	,	,	PUNCT
eurjchem-1234	52	16	respectively	respectively	ADV
eurjchem-1234	52	17	,	,	PUNCT
eurjchem-1234	52	18	were	be	AUX
eurjchem-1234	52	19	prepared	prepare	VERB
eurjchem-1234	52	20	in	in	ADP
eurjchem-1234	52	21	plasma	plasma	NOUN
eurjchem-1234	52	22	for	for	ADP
eurjchem-1234	52	23	the	the	DET
eurjchem-1234	52	24	determination	determination	NOUN
eurjchem-1234	52	25	of	of	ADP
eurjchem-1234	52	26	inter‐assay	inter‐assay	NOUN
eurjchem-1234	52	27	accuracy	accuracy	NOUN
eurjchem-1234	52	28	and	and	CCONJ
eurjchem-1234	52	29	precision	precision	NOUN
eurjchem-1234	52	30	.	.	PUNCT
eurjchem-1234	53	1	aliquots	aliquot	NOUN
eurjchem-1234	53	2	of	of	ADP
eurjchem-1234	53	3	the	the	DET
eurjchem-1234	53	4	standards	standard	NOUN
eurjchem-1234	53	5	and	and	CCONJ
eurjchem-1234	53	6	qc	qc	PROPN
eurjchem-1234	53	7	samples	sample	NOUN
eurjchem-1234	53	8	were	be	AUX
eurjchem-1234	53	9	stored	store	VERB
eurjchem-1234	53	10	frozen	frozen	ADJ
eurjchem-1234	53	11	at	at	ADP
eurjchem-1234	53	12	‐70	‐70	PROPN
eurjchem-1234	53	13	°	°	ADP
eurjchem-1234	53	14	c	c	NOUN
eurjchem-1234	53	15	.	.	PUNCT
eurjchem-1234	54	1	2.4	2.4	NUM
eurjchem-1234	54	2	.	.	PUNCT
eurjchem-1234	55	1	sample	sample	NOUN
eurjchem-1234	55	2	preparation	preparation	NOUN
eurjchem-1234	55	3	50	50	NUM
eurjchem-1234	55	4	µl	µl	NOUN
eurjchem-1234	55	5	of	of	ADP
eurjchem-1234	55	6	chlorpheniramine	chlorpheniramine	NOUN
eurjchem-1234	55	7	is	be	AUX
eurjchem-1234	55	8	(	(	PUNCT
eurjchem-1234	55	9	50	50	NUM
eurjchem-1234	55	10	µg	µg	NOUN
eurjchem-1234	55	11	/	/	SYM
eurjchem-1234	55	12	ml	ml	NOUN
eurjchem-1234	55	13	)	)	PUNCT
eurjchem-1234	55	14	was	be	AUX
eurjchem-1234	55	15	added	add	VERB
eurjchem-1234	55	16	to	to	ADP
eurjchem-1234	55	17	200	200	NUM
eurjchem-1234	55	18	µl	µl	ADP
eurjchem-1234	55	19	metformin	metformin	NOUN
eurjchem-1234	55	20	hydrochloride	hydrochloride	NOUN
eurjchem-1234	55	21	working	work	VERB
eurjchem-1234	55	22	plasma	plasma	NOUN
eurjchem-1234	55	23	solutions	solution	NOUN
eurjchem-1234	55	24	,	,	PUNCT
eurjchem-1234	55	25	vortex	vortex	NOUN
eurjchem-1234	55	26	(	(	PUNCT
eurjchem-1234	55	27	30	30	NUM
eurjchem-1234	55	28	s	s	NOUN
eurjchem-1234	55	29	)	)	PUNCT
eurjchem-1234	55	30	.	.	PUNCT
eurjchem-1234	56	1	the	the	DET
eurjchem-1234	56	2	plasma	plasma	NOUN
eurjchem-1234	56	3	was	be	AUX
eurjchem-1234	56	4	deprotonated	deprotonate	VERB
eurjchem-1234	56	5	with	with	ADP
eurjchem-1234	56	6	acetonitrile	acetonitrile	NOUN
eurjchem-1234	56	7	in	in	ADP
eurjchem-1234	56	8	a	a	DET
eurjchem-1234	56	9	ratio	ratio	NOUN
eurjchem-1234	56	10	of	of	ADP
eurjchem-1234	56	11	plasma	plasma	NOUN
eurjchem-1234	56	12	:	:	PUNCT
eurjchem-1234	56	13	acetonitrile	acetonitrile	NOUN
eurjchem-1234	56	14	(	(	PUNCT
eurjchem-1234	56	15	2:3	2:3	NUM
eurjchem-1234	56	16	,	,	PUNCT
eurjchem-1234	56	17	v	v	NOUN
eurjchem-1234	56	18	:	:	PUNCT
eurjchem-1234	56	19	v	v	NOUN
eurjchem-1234	56	20	)	)	PUNCT
eurjchem-1234	56	21	.	.	PUNCT
eurjchem-1234	57	1	after	after	ADP
eurjchem-1234	57	2	mixing	mix	VERB
eurjchem-1234	57	3	(	(	PUNCT
eurjchem-1234	57	4	30	30	NUM
eurjchem-1234	57	5	s	s	NOUN
eurjchem-1234	57	6	)	)	PUNCT
eurjchem-1234	57	7	and	and	CCONJ
eurjchem-1234	57	8	centrifugation	centrifugation	NOUN
eurjchem-1234	57	9	(	(	PUNCT
eurjchem-1234	57	10	10	10	NUM
eurjchem-1234	57	11	minutes	minute	NOUN
eurjchem-1234	57	12	at	at	ADP
eurjchem-1234	57	13	3500	3500	NUM
eurjchem-1234	57	14	rpm	rpm	NOUN
eurjchem-1234	57	15	)	)	PUNCT
eurjchem-1234	57	16	,	,	PUNCT
eurjchem-1234	57	17	10	10	NUM
eurjchem-1234	57	18	µl	µl	NOUN
eurjchem-1234	57	19	of	of	ADP
eurjchem-1234	57	20	the	the	DET
eurjchem-1234	57	21	clear	clear	ADJ
eurjchem-1234	57	22	supernatant	supernatant	NOUN
eurjchem-1234	57	23	was	be	AUX
eurjchem-1234	57	24	injected	inject	VERB
eurjchem-1234	57	25	into	into	ADP
eurjchem-1234	57	26	the	the	DET
eurjchem-1234	57	27	liquid	liquid	ADJ
eurjchem-1234	57	28	chromato‐	chromato‐	NOUN
eurjchem-1234	57	29	graphic	graphic	ADJ
eurjchem-1234	57	30	system	system	NOUN
eurjchem-1234	57	31	after	after	ADP
eurjchem-1234	57	32	filtration	filtration	NOUN
eurjchem-1234	57	33	through	through	ADP
eurjchem-1234	57	34	whatman	whatman	NOUN
eurjchem-1234	57	35	filter	filter	NOUN
eurjchem-1234	57	36	paper	paper	NOUN
eurjchem-1234	57	37	no	no	INTJ
eurjchem-1234	57	38	.	.	NOUN
eurjchem-1234	58	1	22	22	NUM
eurjchem-1234	58	2	.	.	X
eurjchem-1234	59	1	2.5	2.5	NUM
eurjchem-1234	59	2	.	.	PUNCT
eurjchem-1234	60	1	validation	validation	NOUN
eurjchem-1234	60	2	of	of	ADP
eurjchem-1234	60	3	uplc	uplc	ADJ
eurjchem-1234	60	4	/	/	SYM
eurjchem-1234	60	5	ms	ms	PROPN
eurjchem-1234	60	6	/	/	SYM
eurjchem-1234	60	7	ms	ms	PROPN
eurjchem-1234	60	8	method	method	NOUN
eurjchem-1234	60	9	the	the	DET
eurjchem-1234	60	10	method	method	NOUN
eurjchem-1234	60	11	was	be	AUX
eurjchem-1234	60	12	validated	validate	VERB
eurjchem-1234	60	13	for	for	ADP
eurjchem-1234	60	14	accuracy	accuracy	NOUN
eurjchem-1234	60	15	,	,	PUNCT
eurjchem-1234	60	16	precision	precision	NOUN
eurjchem-1234	60	17	,	,	PUNCT
eurjchem-1234	60	18	sensitivity	sensitivity	NOUN
eurjchem-1234	60	19	,	,	PUNCT
eurjchem-1234	60	20	recovery	recovery	NOUN
eurjchem-1234	60	21	,	,	PUNCT
eurjchem-1234	60	22	matrix	matrix	NOUN
eurjchem-1234	60	23	effect	effect	NOUN
eurjchem-1234	60	24	,	,	PUNCT
eurjchem-1234	60	25	specificity	specificity	NOUN
eurjchem-1234	60	26	,	,	PUNCT
eurjchem-1234	60	27	linearity	linearity	NOUN
eurjchem-1234	60	28	and	and	CCONJ
eurjchem-1234	60	29	reproducibility	reproducibility	NOUN
eurjchem-1234	60	30	according	accord	VERB
eurjchem-1234	60	31	to	to	ADP
eurjchem-1234	60	32	the	the	DET
eurjchem-1234	60	33	fda	fda	PROPN
eurjchem-1234	60	34	guidance	guidance	NOUN
eurjchem-1234	60	35	for	for	ADP
eurjchem-1234	60	36	bio‐	bio‐	PROPN
eurjchem-1234	60	37	analytical	analytical	ADJ
eurjchem-1234	60	38	method	method	NOUN
eurjchem-1234	60	39	validation	validation	NOUN
eurjchem-1234	60	40	[	[	X
eurjchem-1234	60	41	14	14	NUM
eurjchem-1234	60	42	]	]	PUNCT
eurjchem-1234	60	43	over	over	ADP
eurjchem-1234	60	44	a	a	DET
eurjchem-1234	60	45	concentration	concentration	NOUN
eurjchem-1234	60	46	range	range	NOUN
eurjchem-1234	60	47	of	of	ADP
eurjchem-1234	60	48	5.00‐4000,000	5.00‐4000,000	NUM
eurjchem-1234	60	49	ng	ng	NOUN
eurjchem-1234	60	50	/	/	SYM
eurjchem-1234	60	51	ml	ml	X
eurjchem-1234	60	52	using	use	VERB
eurjchem-1234	60	53	six	six	NUM
eurjchem-1234	60	54	calibration	calibration	NOUN
eurjchem-1234	60	55	standards	standard	NOUN
eurjchem-1234	60	56	and	and	CCONJ
eurjchem-1234	60	57	six	six	NUM
eurjchem-1234	60	58	replicates	replicate	NOUN
eurjchem-1234	60	59	of	of	ADP
eurjchem-1234	60	60	qc	qc	PROPN
eurjchem-1234	60	61	samples	sample	NOUN
eurjchem-1234	60	62	at	at	ADP
eurjchem-1234	60	63	each	each	DET
eurjchem-1234	60	64	concentration	concentration	NOUN
eurjchem-1234	60	65	level	level	NOUN
eurjchem-1234	60	66	in	in	ADP
eurjchem-1234	60	67	three	three	NUM
eurjchem-1234	60	68	separate	separate	ADJ
eurjchem-1234	60	69	batch	batch	NOUN
eurjchem-1234	60	70	runs	run	NOUN
eurjchem-1234	60	71	.	.	PUNCT
eurjchem-1234	61	1	analyte	analyte	NOUN
eurjchem-1234	61	2	stability	stability	NOUN
eurjchem-1234	61	3	was	be	AUX
eurjchem-1234	61	4	tested	test	VERB
eurjchem-1234	61	5	using	use	VERB
eurjchem-1234	61	6	qc	qc	PROPN
eurjchem-1234	61	7	samples	sample	NOUN
eurjchem-1234	61	8	for	for	ADP
eurjchem-1234	61	9	multiple	multiple	ADJ
eurjchem-1234	61	10	freeze‐thaw	freeze‐thaw	ADJ
eurjchem-1234	61	11	cycles	cycle	NOUN
eurjchem-1234	61	12	,	,	PUNCT
eurjchem-1234	61	13	on	on	ADP
eurjchem-1234	61	14	the	the	DET
eurjchem-1234	61	15	bench	bench	NOUN
eurjchem-1234	61	16	at	at	ADP
eurjchem-1234	61	17	room	room	NOUN
eurjchem-1234	61	18	temperature	temperature	NOUN
eurjchem-1234	61	19	(	(	PUNCT
eurjchem-1234	61	20	short‐term	short‐term	ADJ
eurjchem-1234	61	21	stability	stability	NOUN
eurjchem-1234	61	22	)	)	PUNCT
eurjchem-1234	61	23	,	,	PUNCT
eurjchem-1234	61	24	or	or	CCONJ
eurjchem-1234	61	25	frozen	freeze	VERB
eurjchem-1234	61	26	at	at	ADP
eurjchem-1234	61	27	‐70	‐70	PROPN
eurjchem-1234	61	28	°	°	ADP
eurjchem-1234	61	29	c	c	PROPN
eurjchem-1234	61	30	(	(	PUNCT
eurjchem-1234	61	31	long‐term	long‐term	NOUN
eurjchem-1234	61	32	storage	storage	NOUN
eurjchem-1234	61	33	)	)	PUNCT
eurjchem-1234	61	34	.	.	PUNCT
eurjchem-1234	62	1	processed	process	VERB
eurjchem-1234	62	2	sample	sample	NOUN
eurjchem-1234	62	3	stability	stability	NOUN
eurjchem-1234	62	4	and	and	CCONJ
eurjchem-1234	62	5	stock	stock	NOUN
eurjchem-1234	62	6	solution	solution	NOUN
eurjchem-1234	62	7	stability	stability	NOUN
eurjchem-1234	62	8	were	be	AUX
eurjchem-1234	62	9	also	also	ADV
eurjchem-1234	62	10	determined	determine	VERB
eurjchem-1234	62	11	.	.	PUNCT
eurjchem-1234	63	1	the	the	DET
eurjchem-1234	63	2	extraction	extraction	NOUN
eurjchem-1234	63	3	recovery	recovery	NOUN
eurjchem-1234	63	4	of	of	ADP
eurjchem-1234	63	5	metformin	metformin	NOUN
eurjchem-1234	63	6	hydrochloride	hydrochloride	NOUN
eurjchem-1234	63	7	was	be	AUX
eurjchem-1234	63	8	calculated	calculate	VERB
eurjchem-1234	63	9	by	by	ADP
eurjchem-1234	63	10	comparing	compare	VERB
eurjchem-1234	63	11	the	the	DET
eurjchem-1234	63	12	peak	peak	NOUN
eurjchem-1234	63	13	areas	area	NOUN
eurjchem-1234	63	14	of	of	ADP
eurjchem-1234	63	15	extracted	extract	VERB
eurjchem-1234	63	16	plasma	plasma	NOUN
eurjchem-1234	63	17	standards	standard	NOUN
eurjchem-1234	63	18	with	with	ADP
eurjchem-1234	63	19	the	the	DET
eurjchem-1234	63	20	peak	peak	NOUN
eurjchem-1234	63	21	areas	area	NOUN
eurjchem-1234	63	22	of	of	ADP
eurjchem-1234	63	23	metformin	metformin	NOUN
eurjchem-1234	63	24	hydrochloride	hydrochloride	NOUN
eurjchem-1234	63	25	in	in	ADP
eurjchem-1234	63	26	the	the	DET
eurjchem-1234	63	27	solvent	solvent	NOUN
eurjchem-1234	63	28	at	at	ADP
eurjchem-1234	63	29	the	the	DET
eurjchem-1234	63	30	correspond‐ding	correspond‐de	VERB
eurjchem-1234	63	31	concentrations	concentration	NOUN
eurjchem-1234	63	32	.	.	PUNCT
eurjchem-1234	64	1	the	the	DET
eurjchem-1234	64	2	method	method	ADJ
eurjchem-1234	64	3	specificity	specificity	NOUN
eurjchem-1234	64	4	was	be	AUX
eurjchem-1234	64	5	evaluated	evaluate	VERB
eurjchem-1234	64	6	by	by	ADP
eurjchem-1234	64	7	screening	screen	VERB
eurjchem-1234	64	8	six	six	NUM
eurjchem-1234	64	9	lots	lot	NOUN
eurjchem-1234	64	10	of	of	ADP
eurjchem-1234	64	11	blank	blank	ADJ
eurjchem-1234	64	12	human	human	ADJ
eurjchem-1234	64	13	plasma	plasma	NOUN
eurjchem-1234	64	14	.	.	PUNCT
eurjchem-1234	65	1	2.6	2.6	NUM
eurjchem-1234	65	2	.	.	PUNCT
eurjchem-1234	66	1	study	study	NOUN
eurjchem-1234	66	2	design	design	NOUN
eurjchem-1234	66	3	this	this	PRON
eurjchem-1234	66	4	was	be	AUX
eurjchem-1234	66	5	a	a	DET
eurjchem-1234	66	6	randomized	randomized	ADJ
eurjchem-1234	66	7	,	,	PUNCT
eurjchem-1234	66	8	open‐label	open‐label	NOUN
eurjchem-1234	66	9	,	,	PUNCT
eurjchem-1234	66	10	2	2	NUM
eurjchem-1234	66	11	ways	way	NOUN
eurjchem-1234	66	12	,	,	PUNCT
eurjchem-1234	66	13	crossover	crossover	ADP
eurjchem-1234	66	14	trial	trial	NOUN
eurjchem-1234	66	15	in	in	ADP
eurjchem-1234	66	16	24	24	NUM
eurjchem-1234	66	17	healthy	healthy	ADJ
eurjchem-1234	66	18	volunteers	volunteer	NOUN
eurjchem-1234	66	19	aged	age	VERB
eurjchem-1234	66	20	18	18	NUM
eurjchem-1234	66	21	to	to	PART
eurjchem-1234	66	22	40	40	NUM
eurjchem-1234	66	23	years	year	NOUN
eurjchem-1234	66	24	,	,	PUNCT
eurjchem-1234	66	25	with	with	ADP
eurjchem-1234	66	26	body	body	NOUN
eurjchem-1234	66	27	mass	mass	NOUN
eurjchem-1234	66	28	indices	index	NOUN
eurjchem-1234	66	29	between	between	ADP
eurjchem-1234	66	30	18	18	NUM
eurjchem-1234	66	31	and	and	CCONJ
eurjchem-1234	66	32	27	27	NUM
eurjchem-1234	66	33	kg	kg	NOUN
eurjchem-1234	66	34	/	/	SYM
eurjchem-1234	66	35	m2	m2	PROPN
eurjchem-1234	66	36	.	.	PUNCT
eurjchem-1234	67	1	subjects	subject	NOUN
eurjchem-1234	67	2	were	be	AUX
eurjchem-1234	67	3	given	give	VERB
eurjchem-1234	67	4	single	single	ADJ
eurjchem-1234	67	5	oral	oral	ADJ
eurjchem-1234	67	6	doses	dose	NOUN
eurjchem-1234	67	7	of	of	ADP
eurjchem-1234	67	8	the	the	DET
eurjchem-1234	67	9	following	follow	VERB
eurjchem-1234	67	10	two	two	NUM
eurjchem-1234	67	11	treatments	treatment	NOUN
eurjchem-1234	67	12	after	after	ADP
eurjchem-1234	67	13	an	an	DET
eurjchem-1234	67	14	overnight	overnight	ADJ
eurjchem-1234	67	15	fast	fast	ADV
eurjchem-1234	67	16	:	:	PUNCT
eurjchem-1234	67	17	mepaphage	mepaphage	NOUN
eurjchem-1234	67	18	500	500	NUM
eurjchem-1234	67	19	mg	mg	NOUN
eurjchem-1234	67	20	film	film	NOUN
eurjchem-1234	67	21	coated	coat	VERB
eurjchem-1234	67	22	tablets	tablet	NOUN
eurjchem-1234	67	23	(	(	PUNCT
eurjchem-1234	67	24	mepaco	mepaco	NOUN
eurjchem-1234	67	25	,	,	PUNCT
eurjchem-1234	67	26	elsharkya	elsharkya	NOUN
eurjchem-1234	67	27	,	,	PUNCT
eurjchem-1234	67	28	egypt	egypt	PROPN
eurjchem-1234	67	29	)	)	PUNCT
eurjchem-1234	67	30	and	and	CCONJ
eurjchem-1234	67	31	glucophage	glucophage	NOUN
eurjchem-1234	67	32	500	500	NUM
eurjchem-1234	67	33	mg	mg	NOUN
eurjchem-1234	67	34	film	film	NOUN
eurjchem-1234	67	35	coated	coat	VERB
eurjchem-1234	67	36	tablets	tablet	NOUN
eurjchem-1234	67	37	(	(	PUNCT
eurjchem-1234	67	38	merck	merck	PROPN
eurjchem-1234	67	39	sante	sante	PROPN
eurjchem-1234	67	40	s.a.s	s.a.s	PROPN
eurjchem-1234	67	41	.	.	PROPN
eurjchem-1234	67	42	,	,	PUNCT
eurjchem-1234	67	43	france	france	PROPN
eurjchem-1234	67	44	)	)	PUNCT
eurjchem-1234	67	45	with	with	ADP
eurjchem-1234	67	46	250	250	NUM
eurjchem-1234	67	47	ml	ml	NOUN
eurjchem-1234	67	48	of	of	ADP
eurjchem-1234	67	49	water	water	NOUN
eurjchem-1234	67	50	.	.	PUNCT
eurjchem-1234	68	1	treatments	treatment	NOUN
eurjchem-1234	68	2	were	be	AUX
eurjchem-1234	68	3	separated	separate	VERB
eurjchem-1234	68	4	by	by	ADP
eurjchem-1234	68	5	1	1	NUM
eurjchem-1234	68	6	week	week	NOUN
eurjchem-1234	68	7	washout	washout	NOUN
eurjchem-1234	68	8	periods	period	VERB
eurjchem-1234	68	9	between	between	ADP
eurjchem-1234	68	10	consecutive	consecutive	ADJ
eurjchem-1234	68	11	doses	dose	NOUN
eurjchem-1234	68	12	.	.	PUNCT
eurjchem-1234	69	1	each	each	DET
eurjchem-1234	69	2	subject	subject	NOUN
eurjchem-1234	69	3	was	be	AUX
eurjchem-1234	69	4	randomized	randomize	VERB
eurjchem-1234	69	5	to	to	PART
eurjchem-1234	69	6	receive	receive	VERB
eurjchem-1234	69	7	the	the	DET
eurjchem-1234	69	8	two	two	NUM
eurjchem-1234	69	9	treatments	treatment	NOUN
eurjchem-1234	69	10	.	.	PUNCT
eurjchem-1234	70	1	key	key	ADJ
eurjchem-1234	70	2	exclusion	exclusion	NOUN
eurjchem-1234	70	3	criteria	criterion	NOUN
eurjchem-1234	70	4	included	include	VERB
eurjchem-1234	70	5	use	use	NOUN
eurjchem-1234	70	6	of	of	ADP
eurjchem-1234	70	7	prescription	prescription	NOUN
eurjchem-1234	70	8	or	or	CCONJ
eurjchem-1234	70	9	nonprescription	nonprescription	NOUN
eurjchem-1234	70	10	drugs	drug	NOUN
eurjchem-1234	70	11	,	,	PUNCT
eurjchem-1234	70	12	vitamins	vitamin	NOUN
eurjchem-1234	70	13	,	,	PUNCT
eurjchem-1234	70	14	or	or	CCONJ
eurjchem-1234	70	15	dietary	dietary	ADJ
eurjchem-1234	70	16	supplements	supplement	NOUN
eurjchem-1234	70	17	within	within	ADP
eurjchem-1234	70	18	7	7	NUM
eurjchem-1234	70	19	days	day	NOUN
eurjchem-1234	70	20	or	or	CCONJ
eurjchem-1234	70	21	5	5	NUM
eurjchem-1234	70	22	half‐lives	half‐live	NOUN
eurjchem-1234	70	23	(	(	PUNCT
eurjchem-1234	70	24	whichever	whichever	PRON
eurjchem-1234	70	25	is	be	AUX
eurjchem-1234	70	26	longer	long	ADJ
eurjchem-1234	70	27	)	)	PUNCT
eurjchem-1234	70	28	before	before	ADP
eurjchem-1234	70	29	the	the	DET
eurjchem-1234	70	30	first	first	ADJ
eurjchem-1234	70	31	dose	dose	NOUN
eurjchem-1234	70	32	of	of	ADP
eurjchem-1234	70	33	study	study	NOUN
eurjchem-1234	70	34	medication	medication	NOUN
eurjchem-1234	70	35	,	,	PUNCT
eurjchem-1234	70	36	except	except	SCONJ
eurjchem-1234	70	37	for	for	ADP
eurjchem-1234	70	38	acetaminophen	acetaminophen	NOUN
eurjchem-1234	70	39	at	at	ADP
eurjchem-1234	70	40	doses	dose	NOUN
eurjchem-1234	70	41	of	of	ADP
eurjchem-1234	70	42	≤1	≤1	PROPN
eurjchem-1234	70	43	g	g	NOUN
eurjchem-1234	70	44	/	/	SYM
eurjchem-1234	70	45	day	day	NOUN
eurjchem-1234	70	46	;	;	PUNCT
eurjchem-1234	70	47	any	any	DET
eurjchem-1234	70	48	clinically	clinically	ADV
eurjchem-1234	70	49	significant	significant	ADJ
eurjchem-1234	70	50	disease	disease	NOUN
eurjchem-1234	70	51	or	or	CCONJ
eurjchem-1234	70	52	drug	drug	NOUN
eurjchem-1234	70	53	allergies	allergy	NOUN
eurjchem-1234	70	54	;	;	PUNCT
eurjchem-1234	70	55	febrile	febrile	NOUN
eurjchem-1234	70	56	illness	illness	NOUN
eurjchem-1234	70	57	within	within	ADP
eurjchem-1234	70	58	the	the	DET
eurjchem-1234	70	59	5	5	NUM
eurjchem-1234	70	60	days	day	NOUN
eurjchem-1234	70	61	before	before	ADP
eurjchem-1234	70	62	first	first	ADJ
eurjchem-1234	70	63	administration	administration	NOUN
eurjchem-1234	70	64	of	of	ADP
eurjchem-1234	70	65	study	study	NOUN
eurjchem-1234	70	66	medication	medication	NOUN
eurjchem-1234	70	67	;	;	PUNCT
eurjchem-1234	70	68	sensitivity	sensitivity	NOUN
eurjchem-1234	70	69	to	to	PART
eurjchem-1234	70	70	heparin	heparin	ADJ
eurjchem-1234	70	71	or	or	CCONJ
eurjchem-1234	70	72	heparin‐induced	heparin‐induce	VERB
eurjchem-1234	70	73	thrombocytopenia	thrombocytopenia	PROPN
eurjchem-1234	70	74	;	;	PUNCT
eurjchem-1234	70	75	a	a	DET
eurjchem-1234	70	76	positive	positive	ADJ
eurjchem-1234	70	77	test	test	NOUN
eurjchem-1234	70	78	result	result	NOUN
eurjchem-1234	70	79	for	for	ADP
eurjchem-1234	70	80	a	a	DET
eurjchem-1234	70	81	drug	drug	NOUN
eurjchem-1234	70	82	of	of	ADP
eurjchem-1234	70	83	abuse	abuse	NOUN
eurjchem-1234	70	84	;	;	PUNCT
eurjchem-1234	70	85	regular	regular	ADJ
eurjchem-1234	70	86	consumption	consumption	NOUN
eurjchem-1234	70	87	of	of	ADP
eurjchem-1234	70	88	alcohol	alcohol	NOUN
eurjchem-1234	70	89	and	and	CCONJ
eurjchem-1234	70	90	excessive	excessive	ADJ
eurjchem-1234	70	91	tobacco	tobacco	NOUN
eurjchem-1234	70	92	or	or	CCONJ
eurjchem-1234	70	93	nicotine	nicotine	NOUN
eurjchem-1234	70	94	use	use	NOUN
eurjchem-1234	70	95	(	(	PUNCT
eurjchem-1234	70	96	equivalent	equivalent	ADJ
eurjchem-1234	70	97	to	to	ADP
eurjchem-1234	70	98	5	5	NUM
eurjchem-1234	70	99	cigars	cigar	NOUN
eurjchem-1234	70	100	per	per	ADP
eurjchem-1234	70	101	day	day	NOUN
eurjchem-1234	70	102	)	)	PUNCT
eurjchem-1234	70	103	.	.	PUNCT
eurjchem-1234	71	1	blood	blood	NOUN
eurjchem-1234	71	2	samples	sample	NOUN
eurjchem-1234	71	3	were	be	AUX
eurjchem-1234	71	4	drawn	draw	VERB
eurjchem-1234	71	5	from	from	ADP
eurjchem-1234	71	6	subjects	subject	NOUN
eurjchem-1234	71	7	before	before	ADP
eurjchem-1234	71	8	dosing	dose	VERB
eurjchem-1234	71	9	and	and	CCONJ
eurjchem-1234	71	10	at	at	ADP
eurjchem-1234	71	11	0.30	0.30	NUM
eurjchem-1234	71	12	,	,	PUNCT
eurjchem-1234	71	13	0.60	0.60	NUM
eurjchem-1234	71	14	,	,	PUNCT
eurjchem-1234	71	15	1.00	1.00	NUM
eurjchem-1234	71	16	,	,	PUNCT
eurjchem-1234	71	17	1.30	1.30	NUM
eurjchem-1234	71	18	,	,	PUNCT
eurjchem-1234	71	19	1.60	1.60	NUM
eurjchem-1234	71	20	,	,	PUNCT
eurjchem-1234	71	21	2.00	2.00	NUM
eurjchem-1234	71	22	,	,	PUNCT
eurjchem-1234	71	23	2.50	2.50	NUM
eurjchem-1234	71	24	,	,	PUNCT
eurjchem-1234	71	25	3.00	3.00	NUM
eurjchem-1234	71	26	,	,	PUNCT
eurjchem-1234	71	27	3.50	3.50	NUM
eurjchem-1234	71	28	,	,	PUNCT
eurjchem-1234	71	29	4.00	4.00	NUM
eurjchem-1234	71	30	,	,	PUNCT
eurjchem-1234	71	31	5.00	5.00	NUM
eurjchem-1234	71	32	,	,	PUNCT
eurjchem-1234	71	33	6.00	6.00	NUM
eurjchem-1234	71	34	,	,	PUNCT
eurjchem-1234	71	35	8.00	8.00	NUM
eurjchem-1234	71	36	,	,	PUNCT
eurjchem-1234	71	37	10.00	10.00	NUM
eurjchem-1234	71	38	,	,	PUNCT
eurjchem-1234	71	39	12.00	12.00	NUM
eurjchem-1234	71	40	,	,	PUNCT
eurjchem-1234	71	41	24.00	24.00	NUM
eurjchem-1234	71	42	and	and	CCONJ
eurjchem-1234	71	43	30.00	30.00	NUM
eurjchem-1234	71	44	h	h	NOUN
eurjchem-1234	71	45	post	post	NOUN
eurjchem-1234	71	46	dose	dose	VERB
eurjchem-1234	71	47	in	in	ADP
eurjchem-1234	71	48	each	each	DET
eurjchem-1234	71	49	treatment	treatment	NOUN
eurjchem-1234	71	50	period	period	NOUN
eurjchem-1234	71	51	.	.	PUNCT
eurjchem-1234	72	1	samples	sample	NOUN
eurjchem-1234	72	2	were	be	AUX
eurjchem-1234	72	3	collected	collect	VERB
eurjchem-1234	72	4	in	in	ADP
eurjchem-1234	72	5	6	6	NUM
eurjchem-1234	72	6	ml	ml	NOUN
eurjchem-1234	72	7	vacutainer	vacutainer	ADJ
eurjchem-1234	72	8	tubes	tube	NOUN
eurjchem-1234	72	9	(	(	PUNCT
eurjchem-1234	72	10	bd	bd	PROPN
eurjchem-1234	72	11	diagnostics	diagnostic	NOUN
eurjchem-1234	72	12	,	,	PUNCT
eurjchem-1234	72	13	franklin	franklin	PROPN
eurjchem-1234	72	14	lakes	lakes	PROPN
eurjchem-1234	72	15	,	,	PUNCT
eurjchem-1234	72	16	nj	nj	PROPN
eurjchem-1234	72	17	)	)	PUNCT
eurjchem-1234	72	18	using	use	VERB
eurjchem-1234	72	19	heparin	heparin	NOUN
eurjchem-1234	72	20	as	as	ADP
eurjchem-1234	72	21	anticoagulant	anticoagulant	NOUN
eurjchem-1234	72	22	,	,	PUNCT
eurjchem-1234	72	23	then	then	ADV
eurjchem-1234	72	24	centrifuged	centrifuge	VERB
eurjchem-1234	72	25	at	at	ADP
eurjchem-1234	72	26	4500	4500	NUM
eurjchem-1234	72	27	rpm	rpm	NOUN
eurjchem-1234	72	28	for	for	ADP
eurjchem-1234	72	29	5	5	NUM
eurjchem-1234	72	30	minutes	minute	NOUN
eurjchem-1234	72	31	to	to	PART
eurjchem-1234	72	32	separate	separate	VERB
eurjchem-1234	72	33	the	the	DET
eurjchem-1234	72	34	plasma	plasma	NOUN
eurjchem-1234	72	35	.	.	PUNCT
eurjchem-1234	73	1	plasma	plasma	NOUN
eurjchem-1234	73	2	samples	sample	NOUN
eurjchem-1234	73	3	were	be	AUX
eurjchem-1234	73	4	transferred	transfer	VERB
eurjchem-1234	73	5	to	to	ADP
eurjchem-1234	73	6	two	two	NUM
eurjchem-1234	73	7	2	2	NUM
eurjchem-1234	73	8	ml	ml	NOUN
eurjchem-1234	73	9	polypropylene	polypropylene	NOUN
eurjchem-1234	73	10	cryogenic	cryogenic	NOUN
eurjchem-1234	73	11	tubes	tube	NOUN
eurjchem-1234	73	12	(	(	PUNCT
eurjchem-1234	73	13	labeled	label	VERB
eurjchem-1234	73	14	retention	retention	NOUN
eurjchem-1234	73	15	sample	sample	NOUN
eurjchem-1234	73	16	and	and	CCONJ
eurjchem-1234	73	17	analyte	analyte	NOUN
eurjchem-1234	73	18	,	,	PUNCT
eurjchem-1234	73	19	respectively	respectively	ADV
eurjchem-1234	73	20	)	)	PUNCT
eurjchem-1234	73	21	and	and	CCONJ
eurjchem-1234	73	22	immediately	immediately	ADV
eurjchem-1234	73	23	stored	store	VERB
eurjchem-1234	73	24	at	at	ADP
eurjchem-1234	73	25	‐70	‐70	PROPN
eurjchem-1234	73	26	°	°	ADP
eurjchem-1234	73	27	c	c	NOUN
eurjchem-1234	73	28	.	.	PUNCT
eurjchem-1234	74	1	2.7	2.7	NUM
eurjchem-1234	74	2	.	.	PUNCT
eurjchem-1234	75	1	statistical	statistical	ADJ
eurjchem-1234	75	2	analyses	analysis	NOUN
eurjchem-1234	75	3	non	non	X
eurjchem-1234	75	4	compartmental	compartmental	ADJ
eurjchem-1234	75	5	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-1234	75	6	analysis	analysis	NOUN
eurjchem-1234	75	7	was	be	AUX
eurjchem-1234	75	8	performed	perform	VERB
eurjchem-1234	75	9	using	use	VERB
eurjchem-1234	75	10	kinetica	kinetica	PROPN
eurjchem-1234	75	11	version	version	NOUN
eurjchem-1234	75	12	5.0	5.0	NUM
eurjchem-1234	75	13	software	software	NOUN
eurjchem-1234	75	14	and	and	CCONJ
eurjchem-1234	75	15	the	the	DET
eurjchem-1234	75	16	following	follow	VERB
eurjchem-1234	75	17	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-1234	75	18	parameters	parameter	NOUN
eurjchem-1234	75	19	were	be	AUX
eurjchem-1234	75	20	calculated	calculate	VERB
eurjchem-1234	75	21	:	:	PUNCT
eurjchem-1234	75	22	maximum	maximum	ADJ
eurjchem-1234	75	23	plasma	plasma	NOUN
eurjchem-1234	75	24	concentration	concentration	NOUN
eurjchem-1234	75	25	cmax	cmax	NOUN
eurjchem-1234	75	26	,	,	PUNCT
eurjchem-1234	75	27	time	time	NOUN
eurjchem-1234	75	28	to	to	PART
eurjchem-1234	75	29	reach	reach	VERB
eurjchem-1234	75	30	cmax	cmax	NOUN
eurjchem-1234	75	31	following	follow	VERB
eurjchem-1234	75	32	drug	drug	NOUN
eurjchem-1234	75	33	administration	administration	NOUN
eurjchem-1234	75	34	tmax	tmax	PROPN
eurjchem-1234	75	35	,	,	PUNCT
eurjchem-1234	75	36	auc0‐t	auc0‐t	NOUN
eurjchem-1234	75	37	:	:	PUNCT
eurjchem-1234	75	38	area	area	NOUN
eurjchem-1234	75	39	under	under	ADP
eurjchem-1234	75	40	the	the	DET
eurjchem-1234	75	41	plasma	plasma	NOUN
eurjchem-1234	75	42	concentration‐time	concentration‐time	NOUN
eurjchem-1234	75	43	curve	curve	NOUN
eurjchem-1234	75	44	,	,	PUNCT
eurjchem-1234	75	45	auc0‐inf	auc0‐inf	ADJ
eurjchem-1234	75	46	:	:	PUNCT
eurjchem-1234	75	47	area	area	NOUN
eurjchem-1234	75	48	under	under	ADP
eurjchem-1234	75	49	the	the	DET
eurjchem-1234	75	50	plasma	plasma	NOUN
eurjchem-1234	75	51	concentration‐time	concentration‐time	NOUN
eurjchem-1234	75	52	curve	curve	NOUN
eurjchem-1234	75	53	from	from	ADP
eurjchem-1234	75	54	time	time	NOUN
eurjchem-1234	75	55	0	0	NUM
eurjchem-1234	75	56	(	(	PUNCT
eurjchem-1234	75	57	administration	administration	NOUN
eurjchem-1234	75	58	)	)	PUNCT
eurjchem-1234	75	59	extrapolated	extrapolate	VERB
eurjchem-1234	75	60	to	to	ADP
eurjchem-1234	75	61	infinity	infinity	NOUN
eurjchem-1234	75	62	,	,	PUNCT
eurjchem-1234	75	63	ke	ke	NOUN
eurjchem-1234	75	64	:	:	PUNCT
eurjchem-1234	75	65	terminal	terminal	ADJ
eurjchem-1234	75	66	elimination	elimination	NOUN
eurjchem-1234	75	67	rate	rate	NOUN
eurjchem-1234	75	68	constant	constant	ADJ
eurjchem-1234	75	69	,	,	PUNCT
eurjchem-1234	75	70	t½	t½	NOUN
eurjchem-1234	75	71	:	:	PUNCT
eurjchem-1234	75	72	elimination	elimination	NOUN
eurjchem-1234	75	73	half‐life	half‐life	NOUN
eurjchem-1234	75	74	.	.	PUNCT
eurjchem-1234	76	1	180	180	NUM
eurjchem-1234	76	2	mohammed	mohammed	PROPN
eurjchem-1234	76	3	et	et	PROPN
eurjchem-1234	76	4	al	al	PROPN
eurjchem-1234	76	5	.	.	PUNCT
eurjchem-1234	76	6	/	/	SYM
eurjchem-1234	76	7	european	european	PROPN
eurjchem-1234	76	8	journal	journal	PROPN
eurjchem-1234	76	9	of	of	ADP
eurjchem-1234	76	10	chemistry	chemistry	NOUN
eurjchem-1234	76	11	6	6	NUM
eurjchem-1234	76	12	(	(	PUNCT
eurjchem-1234	76	13	2	2	NUM
eurjchem-1234	76	14	)	)	PUNCT
eurjchem-1234	76	15	(	(	PUNCT
eurjchem-1234	76	16	2015	2015	NUM
eurjchem-1234	76	17	)	)	PUNCT
eurjchem-1234	76	18	178‐182	178‐182	NOUN
eurjchem-1234	76	19	table	table	NOUN
eurjchem-1234	76	20	1	1	NUM
eurjchem-1234	76	21	.	.	PUNCT
eurjchem-1234	76	22	accuracy	accuracy	NOUN
eurjchem-1234	76	23	of	of	ADP
eurjchem-1234	76	24	calibration	calibration	NOUN
eurjchem-1234	76	25	standards	standard	NOUN
eurjchem-1234	76	26	,	,	PUNCT
eurjchem-1234	76	27	n	n	NOUN
eurjchem-1234	76	28	=	=	SYM
eurjchem-1234	76	29	5	5	X
eurjchem-1234	76	30	.	.	PUNCT
eurjchem-1234	76	31	statistical	statistical	ADJ
eurjchem-1234	76	32	parameters	parameter	NOUN
eurjchem-1234	76	33	concentration	concentration	NOUN
eurjchem-1234	76	34	of	of	ADP
eurjchem-1234	76	35	metformin	metformin	NOUN
eurjchem-1234	76	36	hydrochloride	hydrochloride	NOUN
eurjchem-1234	76	37	(	(	PUNCT
eurjchem-1234	76	38	ng	ng	NOUN
eurjchem-1234	76	39	/	/	SYM
eurjchem-1234	76	40	ml	ml	NOUN
eurjchem-1234	76	41	)	)	PUNCT
eurjchem-1234	76	42	5	5	NUM
eurjchem-1234	76	43	25	25	NUM
eurjchem-1234	76	44	50	50	NUM
eurjchem-1234	76	45	100	100	NUM
eurjchem-1234	76	46	500	500	NUM
eurjchem-1234	76	47	1000	1000	NUM
eurjchem-1234	76	48	2000	2000	NUM
eurjchem-1234	76	49	3000	3000	NUM
eurjchem-1234	76	50	4000	4000	NUM
eurjchem-1234	76	51	found	find	VERB
eurjchem-1234	76	52	mean	mean	ADJ
eurjchem-1234	76	53	plasma	plasma	NOUN
eurjchem-1234	76	54	conc	conc	NOUN
eurjchem-1234	76	55	.	.	PUNCT
eurjchem-1234	77	1	5.15	5.15	NUM
eurjchem-1234	77	2	24.8	24.8	NUM
eurjchem-1234	77	3	50.4	50.4	NUM
eurjchem-1234	77	4	97.0	97.0	NUM
eurjchem-1234	77	5	491.0	491.0	NUM
eurjchem-1234	77	6	960.5	960.5	NUM
eurjchem-1234	77	7	1910.3	1910.3	NUM
eurjchem-1234	77	8	2890.6	2890.6	NUM
eurjchem-1234	77	9	4078.0	4078.0	NUM
eurjchem-1234	77	10	sd	sd	ADP
eurjchem-1234	77	11	a	a	DET
eurjchem-1234	77	12	0.10	0.10	NUM
eurjchem-1234	77	13	0.34	0.34	NUM
eurjchem-1234	77	14	0.96	0.96	NUM
eurjchem-1234	77	15	1.5	1.5	NUM
eurjchem-1234	77	16	2.5	2.5	NUM
eurjchem-1234	77	17	11.2	11.2	NUM
eurjchem-1234	77	18	14.9	14.9	NUM
eurjchem-1234	77	19	23.5	23.5	NUM
eurjchem-1234	77	20	44.6	44.6	NUM
eurjchem-1234	77	21	cv	cv	PROPN
eurjchem-1234	77	22	b	b	PROPN
eurjchem-1234	77	23	1.9	1.9	NUM
eurjchem-1234	77	24	1.4	1.4	NUM
eurjchem-1234	77	25	1.9	1.9	NUM
eurjchem-1234	77	26	1.5	1.5	NUM
eurjchem-1234	77	27	0.5	0.5	NUM
eurjchem-1234	77	28	1.2	1.2	NUM
eurjchem-1234	77	29	0.8	0.8	NUM
eurjchem-1234	77	30	0.8	0.8	NUM
eurjchem-1234	77	31	1.1	1.1	NUM
eurjchem-1234	77	32	accuracy	accuracy	NOUN
eurjchem-1234	77	33	percent	percent	NOUN
eurjchem-1234	77	34	102.70	102.70	NUM
eurjchem-1234	77	35	99.20	99.20	NUM
eurjchem-1234	77	36	100.80	100.80	NUM
eurjchem-1234	77	37	97.00	97.00	NUM
eurjchem-1234	77	38	98.20	98.20	NUM
eurjchem-1234	77	39	96.05	96.05	NUM
eurjchem-1234	77	40	95.50	95.50	NUM
eurjchem-1234	77	41	96.35	96.35	NUM
eurjchem-1234	77	42	101.00	101.00	NUM
eurjchem-1234	77	43	a	a	DET
eurjchem-1234	77	44	sd	sd	NOUN
eurjchem-1234	77	45	,	,	PUNCT
eurjchem-1234	77	46	standard	standard	ADJ
eurjchem-1234	77	47	deviation	deviation	NOUN
eurjchem-1234	77	48	.	.	PUNCT
eurjchem-1234	78	1	b	b	X
eurjchem-1234	78	2	cv	cv	PROPN
eurjchem-1234	78	3	,	,	PUNCT
eurjchem-1234	78	4	coefficient	coefficient	NOUN
eurjchem-1234	78	5	of	of	ADP
eurjchem-1234	78	6	variation	variation	NOUN
eurjchem-1234	78	7	.	.	PUNCT
eurjchem-1234	79	1	3	3	X
eurjchem-1234	79	2	.	.	NOUN
eurjchem-1234	79	3	results	result	NOUN
eurjchem-1234	79	4	and	and	CCONJ
eurjchem-1234	79	5	discussion	discussion	NOUN
eurjchem-1234	79	6	3.1	3.1	NUM
eurjchem-1234	79	7	.	.	PUNCT
eurjchem-1234	80	1	chromatography	chromatography	NOUN
eurjchem-1234	80	2	and	and	CCONJ
eurjchem-1234	80	3	mass	mass	ADJ
eurjchem-1234	80	4	spectrometry	spectrometry	NOUN
eurjchem-1234	80	5	metformin	metformin	NOUN
eurjchem-1234	80	6	hydrochloride	hydrochloride	NOUN
eurjchem-1234	80	7	is	be	AUX
eurjchem-1234	80	8	a	a	DET
eurjchem-1234	80	9	small	small	ADJ
eurjchem-1234	80	10	molecule	molecule	NOUN
eurjchem-1234	80	11	with	with	ADP
eurjchem-1234	80	12	high	high	ADJ
eurjchem-1234	80	13	polarity	polarity	NOUN
eurjchem-1234	80	14	.	.	PUNCT
eurjchem-1234	81	1	the	the	DET
eurjchem-1234	81	2	retention	retention	NOUN
eurjchem-1234	81	3	of	of	ADP
eurjchem-1234	81	4	metformin	metformin	NOUN
eurjchem-1234	81	5	hydrochloride	hydrochloride	NOUN
eurjchem-1234	81	6	on	on	ADP
eurjchem-1234	81	7	reversed‐phase	reversed‐phase	NOUN
eurjchem-1234	81	8	columns	column	NOUN
eurjchem-1234	81	9	was	be	AUX
eurjchem-1234	81	10	very	very	ADV
eurjchem-1234	81	11	poor	poor	ADJ
eurjchem-1234	81	12	.	.	PUNCT
eurjchem-1234	82	1	the	the	DET
eurjchem-1234	82	2	use	use	NOUN
eurjchem-1234	82	3	of	of	ADP
eurjchem-1234	82	4	column	column	NOUN
eurjchem-1234	82	5	suitable	suitable	ADJ
eurjchem-1234	82	6	for	for	ADP
eurjchem-1234	82	7	separation	separation	NOUN
eurjchem-1234	82	8	of	of	ADP
eurjchem-1234	82	9	high	high	ADJ
eurjchem-1234	82	10	polar	polar	ADJ
eurjchem-1234	82	11	compounds	compound	NOUN
eurjchem-1234	82	12	as	as	ADP
eurjchem-1234	82	13	hss	hss	NOUN
eurjchem-1234	82	14	t3	t3	PROPN
eurjchem-1234	82	15	permits	permit	VERB
eurjchem-1234	82	16	the	the	DET
eurjchem-1234	82	17	separation	separation	NOUN
eurjchem-1234	82	18	of	of	ADP
eurjchem-1234	82	19	polar	polar	ADJ
eurjchem-1234	82	20	compound	compound	NOUN
eurjchem-1234	82	21	as	as	ADP
eurjchem-1234	82	22	metformin	metformin	NOUN
eurjchem-1234	82	23	hydrochloride	hydrochloride	NOUN
eurjchem-1234	82	24	.	.	PUNCT
eurjchem-1234	83	1	in	in	ADP
eurjchem-1234	83	2	order	order	NOUN
eurjchem-1234	83	3	to	to	PART
eurjchem-1234	83	4	minimize	minimize	VERB
eurjchem-1234	83	5	the	the	DET
eurjchem-1234	83	6	run	run	ADJ
eurjchem-1234	83	7	time	time	NOUN
eurjchem-1234	83	8	of	of	ADP
eurjchem-1234	83	9	the	the	DET
eurjchem-1234	83	10	assay	assay	NOUN
eurjchem-1234	83	11	,	,	PUNCT
eurjchem-1234	83	12	an	an	DET
eurjchem-1234	83	13	ultra‐performance	ultra‐performance	NOUN
eurjchem-1234	83	14	column	column	NOUN
eurjchem-1234	83	15	was	be	AUX
eurjchem-1234	83	16	used	use	VERB
eurjchem-1234	83	17	.	.	PUNCT
eurjchem-1234	84	1	the	the	DET
eurjchem-1234	84	2	extracted	extract	VERB
eurjchem-1234	84	3	samples	sample	NOUN
eurjchem-1234	84	4	by	by	ADP
eurjchem-1234	84	5	protein	protein	NOUN
eurjchem-1234	84	6	precipitation	precipitation	NOUN
eurjchem-1234	84	7	,	,	PUNCT
eurjchem-1234	84	8	which	which	PRON
eurjchem-1234	84	9	typically	typically	ADV
eurjchem-1234	84	10	contain	contain	VERB
eurjchem-1234	84	11	a	a	DET
eurjchem-1234	84	12	high	high	ADJ
eurjchem-1234	84	13	concentration	concentration	NOUN
eurjchem-1234	84	14	of	of	ADP
eurjchem-1234	84	15	organic	organic	ADJ
eurjchem-1234	84	16	solvent	solvent	NOUN
eurjchem-1234	84	17	is	be	AUX
eurjchem-1234	84	18	not	not	PART
eurjchem-1234	84	19	compatible	compatible	ADJ
eurjchem-1234	84	20	with	with	ADP
eurjchem-1234	84	21	the	the	DET
eurjchem-1234	84	22	separation	separation	NOUN
eurjchem-1234	84	23	using	use	VERB
eurjchem-1234	84	24	reversed	reverse	VERB
eurjchem-1234	84	25	column	column	NOUN
eurjchem-1234	84	26	,	,	PUNCT
eurjchem-1234	84	27	which	which	PRON
eurjchem-1234	84	28	needs	need	VERB
eurjchem-1234	84	29	high	high	ADJ
eurjchem-1234	84	30	aqueous	aqueous	ADJ
eurjchem-1234	84	31	mobile	mobile	ADJ
eurjchem-1234	84	32	phase	phase	NOUN
eurjchem-1234	84	33	to	to	PART
eurjchem-1234	84	34	be	be	AUX
eurjchem-1234	84	35	separated	separate	VERB
eurjchem-1234	84	36	,	,	PUNCT
eurjchem-1234	84	37	while	while	SCONJ
eurjchem-1234	84	38	the	the	DET
eurjchem-1234	84	39	use	use	NOUN
eurjchem-1234	84	40	of	of	ADP
eurjchem-1234	84	41	ultra‐	ultra‐	PROPN
eurjchem-1234	84	42	performance	performance	NOUN
eurjchem-1234	84	43	column	column	NOUN
eurjchem-1234	84	44	hss	hss	PROPN
eurjchem-1234	84	45	t3	t3	PROPN
eurjchem-1234	84	46	permits	permit	VERB
eurjchem-1234	84	47	the	the	DET
eurjchem-1234	84	48	use	use	NOUN
eurjchem-1234	84	49	of	of	ADP
eurjchem-1234	84	50	aqueous	aqueous	ADJ
eurjchem-1234	84	51	mobile	mobile	ADJ
eurjchem-1234	84	52	phase	phase	NOUN
eurjchem-1234	84	53	with	with	ADP
eurjchem-1234	84	54	good	good	ADJ
eurjchem-1234	84	55	separation	separation	NOUN
eurjchem-1234	84	56	.	.	PUNCT
eurjchem-1234	85	1	therefore	therefore	ADV
eurjchem-1234	85	2	a	a	DET
eurjchem-1234	85	3	mixture	mixture	NOUN
eurjchem-1234	85	4	of	of	ADP
eurjchem-1234	85	5	water	water	NOUN
eurjchem-1234	85	6	with	with	ADP
eurjchem-1234	85	7	0.1	0.1	NUM
eurjchem-1234	85	8	%	%	NOUN
eurjchem-1234	85	9	formic	formic	ADJ
eurjchem-1234	85	10	acid	acid	NOUN
eurjchem-1234	85	11	:	:	PUNCT
eurjchem-1234	85	12	acetonitrile	acetonitrile	NOUN
eurjchem-1234	85	13	in	in	ADP
eurjchem-1234	85	14	ratio	ratio	NOUN
eurjchem-1234	85	15	of	of	ADP
eurjchem-1234	85	16	80:20	80:20	NUM
eurjchem-1234	85	17	(	(	PUNCT
eurjchem-1234	85	18	v	v	NOUN
eurjchem-1234	85	19	:	:	PUNCT
eurjchem-1234	85	20	v	v	NOUN
eurjchem-1234	85	21	)	)	PUNCT
eurjchem-1234	85	22	was	be	AUX
eurjchem-1234	85	23	finally	finally	ADV
eurjchem-1234	85	24	adopted	adopt	VERB
eurjchem-1234	85	25	as	as	ADP
eurjchem-1234	85	26	the	the	DET
eurjchem-1234	85	27	mobile	mobile	ADJ
eurjchem-1234	85	28	phase	phase	NOUN
eurjchem-1234	85	29	thus	thus	ADV
eurjchem-1234	85	30	making	make	VERB
eurjchem-1234	85	31	direct	direct	ADJ
eurjchem-1234	85	32	injection	injection	NOUN
eurjchem-1234	85	33	of	of	ADP
eurjchem-1234	85	34	extracted	extract	VERB
eurjchem-1234	85	35	samples	sample	NOUN
eurjchem-1234	85	36	possible	possible	ADJ
eurjchem-1234	85	37	.	.	PUNCT
eurjchem-1234	86	1	the	the	DET
eurjchem-1234	86	2	total	total	ADJ
eurjchem-1234	86	3	run	run	NOUN
eurjchem-1234	86	4	time	time	NOUN
eurjchem-1234	86	5	was	be	AUX
eurjchem-1234	86	6	0.5	0.5	NUM
eurjchem-1234	86	7	min	min	NOUN
eurjchem-1234	86	8	per	per	ADP
eurjchem-1234	86	9	sample	sample	NOUN
eurjchem-1234	86	10	.	.	PUNCT
eurjchem-1234	87	1	the	the	DET
eurjchem-1234	87	2	shortest	short	ADJ
eurjchem-1234	87	3	analysis	analysis	NOUN
eurjchem-1234	87	4	time	time	NOUN
eurjchem-1234	87	5	in	in	ADP
eurjchem-1234	87	6	the	the	DET
eurjchem-1234	87	7	literature	literature	NOUN
eurjchem-1234	87	8	was	be	AUX
eurjchem-1234	87	9	2	2	NUM
eurjchem-1234	87	10	min	min	NOUN
eurjchem-1234	87	11	.	.	PUNCT
eurjchem-1234	88	1	the	the	DET
eurjchem-1234	88	2	shorter	short	ADJ
eurjchem-1234	88	3	analysis	analysis	NOUN
eurjchem-1234	88	4	time	time	NOUN
eurjchem-1234	88	5	would	would	AUX
eurjchem-1234	88	6	better	well	ADV
eurjchem-1234	88	7	meet	meet	VERB
eurjchem-1234	88	8	the	the	DET
eurjchem-1234	88	9	requirements	requirement	NOUN
eurjchem-1234	88	10	for	for	ADP
eurjchem-1234	88	11	high	high	ADJ
eurjchem-1234	88	12	sample	sample	NOUN
eurjchem-1234	88	13	throughput	throughput	NOUN
eurjchem-1234	88	14	in	in	ADP
eurjchem-1234	88	15	bioequivalence	bioequivalence	NOUN
eurjchem-1234	88	16	study	study	NOUN
eurjchem-1234	88	17	.	.	PUNCT
eurjchem-1234	89	1	the	the	DET
eurjchem-1234	89	2	low	low	ADJ
eurjchem-1234	89	3	limit	limit	NOUN
eurjchem-1234	89	4	of	of	ADP
eurjchem-1234	89	5	detection	detection	NOUN
eurjchem-1234	89	6	(	(	PUNCT
eurjchem-1234	89	7	llod	llod	NOUN
eurjchem-1234	89	8	)	)	PUNCT
eurjchem-1234	89	9	for	for	ADP
eurjchem-1234	89	10	metformin	metformin	NOUN
eurjchem-1234	89	11	hydrochloride	hydrochloride	NOUN
eurjchem-1234	89	12	was	be	AUX
eurjchem-1234	89	13	5.00	5.00	NUM
eurjchem-1234	89	14	ng	ng	NOUN
eurjchem-1234	89	15	/	/	SYM
eurjchem-1234	89	16	ml	ml	PROPN
eurjchem-1234	89	17	.	.	PUNCT
eurjchem-1234	90	1	due	due	ADP
eurjchem-1234	90	2	to	to	ADP
eurjchem-1234	90	3	the	the	DET
eurjchem-1234	90	4	lower	low	ADJ
eurjchem-1234	90	5	injection	injection	NOUN
eurjchem-1234	90	6	volume	volume	NOUN
eurjchem-1234	90	7	of	of	ADP
eurjchem-1234	90	8	10	10	NUM
eurjchem-1234	90	9	μl	μl	ADJ
eurjchem-1234	90	10	,	,	PUNCT
eurjchem-1234	90	11	the	the	DET
eurjchem-1234	90	12	on	on	ADP
eurjchem-1234	90	13	column	column	NOUN
eurjchem-1234	90	14	sensitivity	sensitivity	NOUN
eurjchem-1234	90	15	in	in	ADP
eurjchem-1234	90	16	our	our	PRON
eurjchem-1234	90	17	study	study	NOUN
eurjchem-1234	90	18	(	(	PUNCT
eurjchem-1234	90	19	the	the	DET
eurjchem-1234	90	20	quantity	quantity	NOUN
eurjchem-1234	90	21	of	of	ADP
eurjchem-1234	90	22	drug	drug	NOUN
eurjchem-1234	90	23	injected	inject	VERB
eurjchem-1234	90	24	on	on	ADP
eurjchem-1234	90	25	the	the	DET
eurjchem-1234	90	26	column	column	NOUN
eurjchem-1234	90	27	per	per	ADP
eurjchem-1234	90	28	injection	injection	NOUN
eurjchem-1234	90	29	)	)	PUNCT
eurjchem-1234	90	30	was	be	AUX
eurjchem-1234	90	31	50.00	50.00	NUM
eurjchem-1234	90	32	pg	pg	NUM
eurjchem-1234	90	33	which	which	PRON
eurjchem-1234	90	34	is	be	AUX
eurjchem-1234	90	35	lower	low	ADJ
eurjchem-1234	90	36	than	than	ADP
eurjchem-1234	90	37	the	the	DET
eurjchem-1234	90	38	published	publish	VERB
eurjchem-1234	90	39	values	value	NOUN
eurjchem-1234	90	40	.	.	PUNCT
eurjchem-1234	91	1	uplc‐ms‐	uplc‐ms‐	ADJ
eurjchem-1234	91	2	ms	ms	PROPN
eurjchem-1234	91	3	operation	operation	NOUN
eurjchem-1234	91	4	parameters	parameter	NOUN
eurjchem-1234	91	5	were	be	AUX
eurjchem-1234	91	6	carefully	carefully	ADV
eurjchem-1234	91	7	optimized	optimize	VERB
eurjchem-1234	91	8	for	for	ADP
eurjchem-1234	91	9	the	the	DET
eurjchem-1234	91	10	determination	determination	NOUN
eurjchem-1234	91	11	of	of	ADP
eurjchem-1234	91	12	metformin	metformin	NOUN
eurjchem-1234	91	13	hydrochloride	hydrochloride	NOUN
eurjchem-1234	91	14	.	.	PUNCT
eurjchem-1234	92	1	the	the	DET
eurjchem-1234	92	2	mass	mass	PROPN
eurjchem-1234	92	3	spectrometer	spectrometer	NOUN
eurjchem-1234	92	4	was	be	AUX
eurjchem-1234	92	5	in	in	ADP
eurjchem-1234	92	6	positive	positive	ADJ
eurjchem-1234	92	7	ionization	ionization	NOUN
eurjchem-1234	92	8	modes	mode	NOUN
eurjchem-1234	92	9	for	for	ADP
eurjchem-1234	92	10	metformin	metformin	NOUN
eurjchem-1234	92	11	hydrochloride	hydrochloride	NOUN
eurjchem-1234	92	12	.	.	PUNCT
eurjchem-1234	93	1	in	in	ADP
eurjchem-1234	93	2	the	the	DET
eurjchem-1234	93	3	precursor	precursor	NOUN
eurjchem-1234	93	4	ion	ion	NOUN
eurjchem-1234	93	5	full‐scan	full‐scan	NOUN
eurjchem-1234	93	6	spectra	spectra	NOUN
eurjchem-1234	93	7	,	,	PUNCT
eurjchem-1234	93	8	the	the	DET
eurjchem-1234	93	9	most	most	ADV
eurjchem-1234	93	10	abundant	abundant	ADJ
eurjchem-1234	93	11	ions	ion	NOUN
eurjchem-1234	93	12	were	be	AUX
eurjchem-1234	93	13	protonated	protonate	VERB
eurjchem-1234	93	14	molecules	molecule	NOUN
eurjchem-1234	93	15	(	(	PUNCT
eurjchem-1234	93	16	m+h)+	m+h)+	NOUN
eurjchem-1234	93	17	m	m	PROPN
eurjchem-1234	93	18	/	/	SYM
eurjchem-1234	93	19	z	z	PROPN
eurjchem-1234	93	20	129.93	129.93	NUM
eurjchem-1234	93	21	,	,	PUNCT
eurjchem-1234	93	22	and	and	CCONJ
eurjchem-1234	93	23	275.14	275.14	NUM
eurjchem-1234	93	24	for	for	ADP
eurjchem-1234	93	25	metformin	metformin	NOUN
eurjchem-1234	93	26	hydrochloride	hydrochloride	NOUN
eurjchem-1234	93	27	and	and	CCONJ
eurjchem-1234	93	28	i.s	i.s	PROPN
eurjchem-1234	93	29	.	.	PROPN
eurjchem-1234	93	30	,	,	PUNCT
eurjchem-1234	93	31	respectively	respectively	ADV
eurjchem-1234	93	32	.	.	PUNCT
eurjchem-1234	94	1	the	the	DET
eurjchem-1234	94	2	product	product	NOUN
eurjchem-1234	94	3	ion	ion	NOUN
eurjchem-1234	94	4	scan	scan	PROPN
eurjchem-1234	94	5	spectra	spectra	PROPN
eurjchem-1234	94	6	showed	show	VERB
eurjchem-1234	94	7	high	high	ADJ
eurjchem-1234	94	8	abundance	abundance	NOUN
eurjchem-1234	94	9	fragment	fragment	NOUN
eurjchem-1234	94	10	ions	ion	NOUN
eurjchem-1234	94	11	at	at	ADP
eurjchem-1234	94	12	m	m	PROPN
eurjchem-1234	94	13	/	/	SYM
eurjchem-1234	94	14	z	z	PROPN
eurjchem-1234	94	15	59.99	59.99	NUM
eurjchem-1234	94	16	and	and	CCONJ
eurjchem-1234	94	17	229.93	229.93	NUM
eurjchem-1234	94	18	for	for	ADP
eurjchem-1234	94	19	metformin	metformin	NOUN
eurjchem-1234	94	20	hydrochloride	hydrochloride	NOUN
eurjchem-1234	94	21	and	and	CCONJ
eurjchem-1234	94	22	i.s	i.s	PROPN
eurjchem-1234	94	23	.	.	PROPN
eurjchem-1234	94	24	,	,	PUNCT
eurjchem-1234	94	25	respectively	respectively	ADV
eurjchem-1234	94	26	.	.	PUNCT
eurjchem-1234	95	1	retention	retention	NOUN
eurjchem-1234	95	2	time	time	NOUN
eurjchem-1234	95	3	of	of	ADP
eurjchem-1234	95	4	metformin	metformin	NOUN
eurjchem-1234	95	5	hydrochloride	hydrochloride	NOUN
eurjchem-1234	95	6	was	be	AUX
eurjchem-1234	95	7	0.20	0.20	NUM
eurjchem-1234	95	8	min	min	NOUN
eurjchem-1234	95	9	and	and	CCONJ
eurjchem-1234	95	10	that	that	SCONJ
eurjchem-1234	95	11	for	for	ADP
eurjchem-1234	95	12	chlorpheniramine	chlorpheniramine	NOUN
eurjchem-1234	95	13	was	be	AUX
eurjchem-1234	95	14	0.21	0.21	NUM
eurjchem-1234	95	15	min	min	NOUN
eurjchem-1234	95	16	,	,	PUNCT
eurjchem-1234	95	17	figure	figure	NOUN
eurjchem-1234	95	18	2	2	NUM
eurjchem-1234	95	19	.	.	NOUN
eurjchem-1234	95	20	3.2	3.2	NUM
eurjchem-1234	95	21	.	.	PUNCT
eurjchem-1234	96	1	sample	sample	NOUN
eurjchem-1234	96	2	preparation	preparation	NOUN
eurjchem-1234	96	3	liquid‐liquid	liquid‐liquid	NOUN
eurjchem-1234	96	4	extraction	extraction	NOUN
eurjchem-1234	96	5	(	(	PUNCT
eurjchem-1234	96	6	lle	lle	PROPN
eurjchem-1234	96	7	)	)	PUNCT
eurjchem-1234	96	8	and	and	CCONJ
eurjchem-1234	96	9	solid‐phase	solid‐phase	NOUN
eurjchem-1234	96	10	extraction	extraction	NOUN
eurjchem-1234	96	11	(	(	PUNCT
eurjchem-1234	96	12	spe	spe	X
eurjchem-1234	96	13	)	)	PUNCT
eurjchem-1234	96	14	are	be	AUX
eurjchem-1234	96	15	techniques	technique	NOUN
eurjchem-1234	96	16	often	often	ADV
eurjchem-1234	96	17	used	use	VERB
eurjchem-1234	96	18	in	in	ADP
eurjchem-1234	96	19	the	the	DET
eurjchem-1234	96	20	preparation	preparation	NOUN
eurjchem-1234	96	21	of	of	ADP
eurjchem-1234	96	22	biological	biological	ADJ
eurjchem-1234	96	23	samples	sample	NOUN
eurjchem-1234	96	24	as	as	SCONJ
eurjchem-1234	96	25	they	they	PRON
eurjchem-1234	96	26	often	often	ADV
eurjchem-1234	96	27	improve	improve	VERB
eurjchem-1234	96	28	the	the	DET
eurjchem-1234	96	29	sensitivity	sensitivity	NOUN
eurjchem-1234	96	30	and	and	CCONJ
eurjchem-1234	96	31	robustness	robustness	NOUN
eurjchem-1234	96	32	of	of	ADP
eurjchem-1234	96	33	the	the	DET
eurjchem-1234	96	34	assay	assay	NOUN
eurjchem-1234	96	35	.	.	PUNCT
eurjchem-1234	97	1	however	however	ADV
eurjchem-1234	97	2	,	,	PUNCT
eurjchem-1234	97	3	metformin	metformin	NOUN
eurjchem-1234	97	4	hydrochloride	hydrochloride	NOUN
eurjchem-1234	97	5	had	have	VERB
eurjchem-1234	97	6	a	a	DET
eurjchem-1234	97	7	very	very	ADV
eurjchem-1234	97	8	high	high	ADJ
eurjchem-1234	97	9	polarity	polarity	NOUN
eurjchem-1234	97	10	,	,	PUNCT
eurjchem-1234	97	11	so	so	ADV
eurjchem-1234	97	12	it	it	PRON
eurjchem-1234	97	13	was	be	AUX
eurjchem-1234	97	14	impossible	impossible	ADJ
eurjchem-1234	97	15	to	to	PART
eurjchem-1234	97	16	extract	extract	VERB
eurjchem-1234	97	17	it	it	PRON
eurjchem-1234	97	18	from	from	ADP
eurjchem-1234	97	19	biological	biological	ADJ
eurjchem-1234	97	20	fluids	fluid	NOUN
eurjchem-1234	97	21	using	use	VERB
eurjchem-1234	97	22	liquid‐liquid	liquid‐liquid	ADJ
eurjchem-1234	97	23	extraction	extraction	NOUN
eurjchem-1234	97	24	method	method	NOUN
eurjchem-1234	97	25	.	.	PUNCT
eurjchem-1234	98	1	on	on	ADP
eurjchem-1234	98	2	the	the	DET
eurjchem-1234	98	3	other	other	ADJ
eurjchem-1234	98	4	hand	hand	NOUN
eurjchem-1234	98	5	,	,	PUNCT
eurjchem-1234	98	6	spe	spe	PROPN
eurjchem-1234	98	7	would	would	AUX
eurjchem-1234	98	8	not	not	PART
eurjchem-1234	98	9	be	be	AUX
eurjchem-1234	98	10	cost	cost	VERB
eurjchem-1234	98	11	effective	effective	ADJ
eurjchem-1234	98	12	in	in	ADP
eurjchem-1234	98	13	a	a	DET
eurjchem-1234	98	14	high	high	ADJ
eurjchem-1234	98	15	throughput	throughput	NOUN
eurjchem-1234	98	16	analysis	analysis	NOUN
eurjchem-1234	98	17	involving	involve	VERB
eurjchem-1234	98	18	many	many	ADJ
eurjchem-1234	98	19	samples	sample	NOUN
eurjchem-1234	98	20	.	.	PUNCT
eurjchem-1234	99	1	therefore	therefore	ADV
eurjchem-1234	99	2	,	,	PUNCT
eurjchem-1234	99	3	in	in	ADP
eurjchem-1234	99	4	the	the	DET
eurjchem-1234	99	5	present	present	ADJ
eurjchem-1234	99	6	experiment	experiment	NOUN
eurjchem-1234	99	7	,	,	PUNCT
eurjchem-1234	99	8	a	a	DET
eurjchem-1234	99	9	simple	simple	ADJ
eurjchem-1234	99	10	protein	protein	NOUN
eurjchem-1234	99	11	precipitation	precipitation	NOUN
eurjchem-1234	99	12	procedure	procedure	NOUN
eurjchem-1234	99	13	was	be	AUX
eurjchem-1234	99	14	developed	develop	VERB
eurjchem-1234	99	15	to	to	PART
eurjchem-1234	99	16	reduce	reduce	VERB
eurjchem-1234	99	17	sample	sample	NOUN
eurjchem-1234	99	18	preparation	preparation	NOUN
eurjchem-1234	99	19	time	time	NOUN
eurjchem-1234	99	20	.	.	PUNCT
eurjchem-1234	100	1	no	no	DET
eurjchem-1234	100	2	further	further	ADJ
eurjchem-1234	100	3	concentration	concentration	NOUN
eurjchem-1234	100	4	procedure	procedure	NOUN
eurjchem-1234	100	5	was	be	AUX
eurjchem-1234	100	6	needed	need	VERB
eurjchem-1234	100	7	and	and	CCONJ
eurjchem-1234	100	8	the	the	DET
eurjchem-1234	100	9	sample	sample	NOUN
eurjchem-1234	100	10	preparation	preparation	NOUN
eurjchem-1234	100	11	procedure	procedure	NOUN
eurjchem-1234	100	12	was	be	AUX
eurjchem-1234	100	13	simplified	simplify	VERB
eurjchem-1234	100	14	.	.	PUNCT
eurjchem-1234	101	1	to	to	PART
eurjchem-1234	101	2	test	test	VERB
eurjchem-1234	101	3	extraction	extraction	NOUN
eurjchem-1234	101	4	efficiency	efficiency	NOUN
eurjchem-1234	101	5	,	,	PUNCT
eurjchem-1234	101	6	three	three	NUM
eurjchem-1234	101	7	different	different	ADJ
eurjchem-1234	101	8	protein	protein	NOUN
eurjchem-1234	101	9	precipitation	precipitation	NOUN
eurjchem-1234	101	10	agents	agent	NOUN
eurjchem-1234	101	11	(	(	PUNCT
eurjchem-1234	101	12	acetonitrile	acetonitrile	NOUN
eurjchem-1234	101	13	,	,	PUNCT
eurjchem-1234	101	14	methanol	methanol	NOUN
eurjchem-1234	101	15	,	,	PUNCT
eurjchem-1234	101	16	and	and	CCONJ
eurjchem-1234	101	17	acetone	acetone	NOUN
eurjchem-1234	101	18	)	)	PUNCT
eurjchem-1234	101	19	were	be	AUX
eurjchem-1234	101	20	investigated	investigate	VERB
eurjchem-1234	101	21	.	.	PUNCT
eurjchem-1234	102	1	acetonitrile	acetonitrile	NOUN
eurjchem-1234	102	2	had	have	VERB
eurjchem-1234	102	3	a	a	DET
eurjchem-1234	102	4	higher	high	ADJ
eurjchem-1234	102	5	efficiency	efficiency	NOUN
eurjchem-1234	102	6	of	of	ADP
eurjchem-1234	102	7	precipitation	precipitation	NOUN
eurjchem-1234	102	8	of	of	ADP
eurjchem-1234	102	9	protein	protein	NOUN
eurjchem-1234	102	10	with	with	ADP
eurjchem-1234	102	11	minimal	minimal	ADJ
eurjchem-1234	102	12	loss	loss	NOUN
eurjchem-1234	102	13	of	of	ADP
eurjchem-1234	102	14	extracted	extract	VERB
eurjchem-1234	102	15	drug	drug	NOUN
eurjchem-1234	102	16	sample	sample	NOUN
eurjchem-1234	102	17	.	.	PUNCT
eurjchem-1234	103	1	(	(	PUNCT
eurjchem-1234	103	2	a	a	X
eurjchem-1234	103	3	)	)	PUNCT
eurjchem-1234	103	4	(	(	PUNCT
eurjchem-1234	103	5	b	b	X
eurjchem-1234	103	6	)	)	PUNCT
eurjchem-1234	103	7	figure	figure	NOUN
eurjchem-1234	103	8	2	2	NUM
eurjchem-1234	103	9	.	.	PUNCT
eurjchem-1234	103	10	typical	typical	ADJ
eurjchem-1234	103	11	chromatogram	chromatogram	NOUN
eurjchem-1234	103	12	of	of	ADP
eurjchem-1234	103	13	metformin	metformin	NOUN
eurjchem-1234	103	14	hydrochloride	hydrochloride	NOUN
eurjchem-1234	103	15	(	(	PUNCT
eurjchem-1234	103	16	rt	rt	NOUN
eurjchem-1234	103	17	:	:	PUNCT
eurjchem-1234	103	18	2.00	2.00	NUM
eurjchem-1234	103	19	min	min	NOUN
eurjchem-1234	103	20	)	)	PUNCT
eurjchem-1234	103	21	(	(	PUNCT
eurjchem-1234	103	22	a	a	X
eurjchem-1234	103	23	)	)	PUNCT
eurjchem-1234	103	24	and	and	CCONJ
eurjchem-1234	103	25	chlorpheniramine	chlorpheniramine	PROPN
eurjchem-1234	103	26	(	(	PUNCT
eurjchem-1234	103	27	rt	rt	NOUN
eurjchem-1234	103	28	:	:	PUNCT
eurjchem-1234	103	29	2.10	2.10	NUM
eurjchem-1234	103	30	min	min	NOUN
eurjchem-1234	103	31	)	)	PUNCT
eurjchem-1234	103	32	(	(	PUNCT
eurjchem-1234	103	33	b	b	NOUN
eurjchem-1234	103	34	)	)	PUNCT
eurjchem-1234	103	35	.	.	PUNCT
eurjchem-1234	104	1	3.3	3.3	NUM
eurjchem-1234	104	2	.	.	PUNCT
eurjchem-1234	105	1	method	method	NOUN
eurjchem-1234	105	2	validation	validation	NOUN
eurjchem-1234	105	3	3.3.1	3.3.1	PROPN
eurjchem-1234	105	4	.	.	PUNCT
eurjchem-1234	106	1	selectivity	selectivity	NOUN
eurjchem-1234	106	2	selectivity	selectivity	NOUN
eurjchem-1234	106	3	is	be	AUX
eurjchem-1234	106	4	defined	define	VERB
eurjchem-1234	106	5	as	as	ADP
eurjchem-1234	106	6	the	the	DET
eurjchem-1234	106	7	ability	ability	NOUN
eurjchem-1234	106	8	of	of	ADP
eurjchem-1234	106	9	a	a	DET
eurjchem-1234	106	10	chromatographic	chromatographic	ADJ
eurjchem-1234	106	11	method	method	NOUN
eurjchem-1234	106	12	to	to	PART
eurjchem-1234	106	13	measure	measure	VERB
eurjchem-1234	106	14	a	a	DET
eurjchem-1234	106	15	response	response	NOUN
eurjchem-1234	106	16	of	of	ADP
eurjchem-1234	106	17	the	the	DET
eurjchem-1234	106	18	analyte	analyte	NOUN
eurjchem-1234	106	19	without	without	ADP
eurjchem-1234	106	20	interference	interference	NOUN
eurjchem-1234	106	21	from	from	ADP
eurjchem-1234	106	22	the	the	DET
eurjchem-1234	106	23	biological	biological	ADJ
eurjchem-1234	106	24	matrix	matrix	NOUN
eurjchem-1234	106	25	.	.	PUNCT
eurjchem-1234	107	1	this	this	PRON
eurjchem-1234	107	2	was	be	AUX
eurjchem-1234	107	3	assessed	assess	VERB
eurjchem-1234	107	4	by	by	ADP
eurjchem-1234	107	5	evaluating	evaluate	VERB
eurjchem-1234	107	6	six	six	NUM
eurjchem-1234	107	7	individual	individual	ADJ
eurjchem-1234	107	8	lots	lot	NOUN
eurjchem-1234	107	9	of	of	ADP
eurjchem-1234	107	10	human	human	ADJ
eurjchem-1234	107	11	plasma	plasma	NOUN
eurjchem-1234	107	12	with	with	ADP
eurjchem-1234	107	13	the	the	DET
eurjchem-1234	107	14	corresponding	corresponding	ADJ
eurjchem-1234	107	15	spiked	spiked	ADJ
eurjchem-1234	107	16	plasma	plasma	NOUN
eurjchem-1234	107	17	.	.	PUNCT
eurjchem-1234	108	1	there	there	PRON
eurjchem-1234	108	2	were	be	VERB
eurjchem-1234	108	3	no	no	DET
eurjchem-1234	108	4	endogenous	endogenous	ADJ
eurjchem-1234	108	5	peaks	peak	NOUN
eurjchem-1234	108	6	that	that	PRON
eurjchem-1234	108	7	interfered	interfere	VERB
eurjchem-1234	108	8	with	with	ADP
eurjchem-1234	108	9	the	the	DET
eurjchem-1234	108	10	quantitation	quantitation	NOUN
eurjchem-1234	108	11	of	of	ADP
eurjchem-1234	108	12	metformin	metformin	NOUN
eurjchem-1234	108	13	hydrochloride	hydrochloride	NOUN
eurjchem-1234	108	14	or	or	CCONJ
eurjchem-1234	108	15	internal	internal	ADJ
eurjchem-1234	108	16	standard	standard	NOUN
eurjchem-1234	108	17	.	.	PUNCT
eurjchem-1234	109	1	3.3.2	3.3.2	NUM
eurjchem-1234	109	2	.	.	X
eurjchem-1234	109	3	linearity	linearity	NOUN
eurjchem-1234	109	4	and	and	CCONJ
eurjchem-1234	109	5	lloq	lloq	VERB
eurjchem-1234	109	6	the	the	DET
eurjchem-1234	109	7	standard	standard	ADJ
eurjchem-1234	109	8	calibration	calibration	NOUN
eurjchem-1234	109	9	curves	curve	NOUN
eurjchem-1234	109	10	for	for	ADP
eurjchem-1234	109	11	metformin	metformin	NOUN
eurjchem-1234	109	12	hydrochloride	hydrochloride	NOUN
eurjchem-1234	109	13	was	be	AUX
eurjchem-1234	109	14	linear	linear	ADJ
eurjchem-1234	109	15	over	over	ADP
eurjchem-1234	109	16	the	the	DET
eurjchem-1234	109	17	concentration	concentration	NOUN
eurjchem-1234	109	18	range	range	NOUN
eurjchem-1234	109	19	of	of	ADP
eurjchem-1234	109	20	5.00‐	5.00‐	NUM
eurjchem-1234	109	21	4000.00	4000.00	NUM
eurjchem-1234	109	22	ng	ng	PROPN
eurjchem-1234	109	23	/	/	SYM
eurjchem-1234	109	24	ml	ml	PROPN
eurjchem-1234	109	25	(	(	PUNCT
eurjchem-1234	109	26	r2	r2	PROPN
eurjchem-1234	109	27	>	>	X
eurjchem-1234	109	28	0.999	0.999	NUM
eurjchem-1234	109	29	)	)	PUNCT
eurjchem-1234	109	30	.	.	PUNCT
eurjchem-1234	110	1	the	the	DET
eurjchem-1234	110	2	typical	typical	ADJ
eurjchem-1234	110	3	equations	equation	NOUN
eurjchem-1234	110	4	for	for	ADP
eurjchem-1234	110	5	the	the	DET
eurjchem-1234	110	6	calibration	calibration	NOUN
eurjchem-1234	110	7	curves	curve	NOUN
eurjchem-1234	110	8	for	for	ADP
eurjchem-1234	110	9	metformin	metformin	NOUN
eurjchem-1234	110	10	hydrochloride	hydrochloride	NOUN
eurjchem-1234	110	11	was	be	AUX
eurjchem-1234	110	12	y	y	PROPN
eurjchem-1234	110	13	=	=	PUNCT
eurjchem-1234	110	14	0.0005‐0.0074x	0.0005‐0.0074x	PROPN
eurjchem-1234	110	15	&	&	CCONJ
eurjchem-1234	110	16	r2	r2	PROPN
eurjchem-1234	110	17	=	=	PUNCT
eurjchem-1234	110	18	0.9997	0.9997	NUM
eurjchem-1234	110	19	.	.	PUNCT
eurjchem-1234	111	1	the	the	DET
eurjchem-1234	111	2	lower	low	ADJ
eurjchem-1234	111	3	limit	limit	NOUN
eurjchem-1234	111	4	of	of	ADP
eurjchem-1234	111	5	quantification	quantification	NOUN
eurjchem-1234	111	6	for	for	ADP
eurjchem-1234	111	7	metformin	metformin	NOUN
eurjchem-1234	111	8	hydrochloride	hydrochloride	NOUN
eurjchem-1234	111	9	was	be	AUX
eurjchem-1234	111	10	10.000	10.000	NUM
eurjchem-1234	111	11	ng	ng	NOUN
eurjchem-1234	111	12	/	/	SYM
eurjchem-1234	111	13	ml	ml	PROPN
eurjchem-1234	111	14	.	.	PUNCT
eurjchem-1234	112	1	a	a	DET
eurjchem-1234	112	2	typical	typical	ADJ
eurjchem-1234	112	3	chromatogram	chromatogram	NOUN
eurjchem-1234	112	4	is	be	AUX
eurjchem-1234	112	5	shown	show	VERB
eurjchem-1234	112	6	in	in	ADP
eurjchem-1234	112	7	figure	figure	NOUN
eurjchem-1234	112	8	2	2	NUM
eurjchem-1234	112	9	.	.	X
eurjchem-1234	113	1	3.3.3	3.3.3	NUM
eurjchem-1234	113	2	.	.	PUNCT
eurjchem-1234	114	1	precision	precision	NOUN
eurjchem-1234	114	2	,	,	PUNCT
eurjchem-1234	114	3	accuracy	accuracy	NOUN
eurjchem-1234	114	4	and	and	CCONJ
eurjchem-1234	114	5	dilution	dilution	NOUN
eurjchem-1234	114	6	integrity	integrity	NOUN
eurjchem-1234	114	7	table	table	NOUN
eurjchem-1234	114	8	1	1	NUM
eurjchem-1234	114	9	shows	show	VERB
eurjchem-1234	114	10	the	the	DET
eurjchem-1234	114	11	validation	validation	NOUN
eurjchem-1234	114	12	data	datum	NOUN
eurjchem-1234	114	13	on	on	ADP
eurjchem-1234	114	14	accuracy	accuracy	NOUN
eurjchem-1234	114	15	of	of	ADP
eurjchem-1234	114	16	each	each	DET
eurjchem-1234	114	17	standard	standard	ADJ
eurjchem-1234	114	18	concentration	concentration	NOUN
eurjchem-1234	114	19	.	.	PUNCT
eurjchem-1234	115	1	the	the	DET
eurjchem-1234	115	2	cvs	cvs	NOUN
eurjchem-1234	115	3	for	for	ADP
eurjchem-1234	115	4	the	the	DET
eurjchem-1234	115	5	back‐calculated	back‐calculated	ADJ
eurjchem-1234	115	6	calibration	calibration	NOUN
eurjchem-1234	115	7	standards	standard	NOUN
eurjchem-1234	115	8	at	at	ADP
eurjchem-1234	115	9	5.00	5.00	NUM
eurjchem-1234	115	10	and	and	CCONJ
eurjchem-1234	115	11	4000.0	4000.0	NUM
eurjchem-1234	115	12	ng	ng	NOUN
eurjchem-1234	115	13	/	/	SYM
eurjchem-1234	115	14	ml	ml	PROPN
eurjchem-1234	115	15	were	be	AUX
eurjchem-1234	115	16	1.9	1.9	NUM
eurjchem-1234	115	17	and	and	CCONJ
eurjchem-1234	115	18	1.1	1.1	NUM
eurjchem-1234	115	19	%	%	NOUN
eurjchem-1234	115	20	,	,	PUNCT
eurjchem-1234	115	21	respectively	respectively	ADV
eurjchem-1234	115	22	.	.	PUNCT
eurjchem-1234	116	1	the	the	DET
eurjchem-1234	116	2	precision	precision	NOUN
eurjchem-1234	116	3	and	and	CCONJ
eurjchem-1234	116	4	accuracy	accuracy	NOUN
eurjchem-1234	116	5	data	datum	NOUN
eurjchem-1234	116	6	for	for	ADP
eurjchem-1234	116	7	qcs	qcs	PROPN
eurjchem-1234	116	8	are	be	AUX
eurjchem-1234	116	9	summarized	summarize	VERB
eurjchem-1234	116	10	in	in	ADP
eurjchem-1234	116	11	table	table	NOUN
eurjchem-1234	116	12	2	2	NUM
eurjchem-1234	116	13	.	.	PUNCT
eurjchem-1234	116	14	for	for	ADP
eurjchem-1234	116	15	qcs	qcs	PROPN
eurjchem-1234	116	16	at	at	ADP
eurjchem-1234	116	17	10.00	10.00	NUM
eurjchem-1234	116	18	,	,	PUNCT
eurjchem-1234	116	19	2000.00	2000.00	NUM
eurjchem-1234	116	20	and	and	CCONJ
eurjchem-1234	116	21	4000.00	4000.00	NUM
eurjchem-1234	116	22	ng	ng	PROPN
eurjchem-1234	116	23	/	/	SYM
eurjchem-1234	116	24	ml	ml	PROPN
eurjchem-1234	116	25	,	,	PUNCT
eurjchem-1234	116	26	inter‐assay	inter‐assay	PROPN
eurjchem-1234	116	27	cv	cv	PROPN
eurjchem-1234	116	28	values	value	NOUN
eurjchem-1234	116	29	were	be	AUX
eurjchem-1234	116	30	1.5	1.5	NUM
eurjchem-1234	116	31	,	,	PUNCT
eurjchem-1234	116	32	0.4	0.4	NUM
eurjchem-1234	116	33	and	and	CCONJ
eurjchem-1234	116	34	2.0	2.0	NUM
eurjchem-1234	116	35	%	%	NOUN
eurjchem-1234	116	36	,	,	PUNCT
eurjchem-1234	116	37	respectively	respectively	ADV
eurjchem-1234	116	38	,	,	PUNCT
eurjchem-1234	116	39	and	and	CCONJ
eurjchem-1234	116	40	the	the	DET
eurjchem-1234	116	41	percentage	percentage	NOUN
eurjchem-1234	116	42	of	of	ADP
eurjchem-1234	116	43	nominal	nominal	NOUN
eurjchem-1234	116	44	ranged	range	VERB
eurjchem-1234	116	45	from	from	ADP
eurjchem-1234	116	46	99.0	99.0	NUM
eurjchem-1234	116	47	to	to	ADP
eurjchem-1234	116	48	101.8	101.8	NUM
eurjchem-1234	116	49	%	%	NOUN
eurjchem-1234	116	50	.	.	PUNCT
eurjchem-1234	117	1	intra‐assay	intra‐assay	PROPN
eurjchem-1234	117	2	cv	cv	PROPN
eurjchem-1234	117	3	values	value	NOUN
eurjchem-1234	117	4	for	for	ADP
eurjchem-1234	117	5	qcs	qcs	PROPN
eurjchem-1234	117	6	at	at	ADP
eurjchem-1234	117	7	10	10	NUM
eurjchem-1234	117	8	,	,	PUNCT
eurjchem-1234	117	9	2000	2000	NUM
eurjchem-1234	117	10	and	and	CCONJ
eurjchem-1234	117	11	4000	4000	NUM
eurjchem-1234	117	12	ng	ng	NOUN
eurjchem-1234	117	13	/	/	SYM
eurjchem-1234	117	14	ml	ml	PROPN
eurjchem-1234	117	15	were	be	AUX
eurjchem-1234	117	16	2.1	2.1	NUM
eurjchem-1234	117	17	,	,	PUNCT
eurjchem-1234	117	18	0.9	0.9	NUM
eurjchem-1234	117	19	and	and	CCONJ
eurjchem-1234	117	20	1.3	1.3	NUM
eurjchem-1234	117	21	%	%	NOUN
eurjchem-1234	117	22	,	,	PUNCT
eurjchem-1234	117	23	and	and	CCONJ
eurjchem-1234	117	24	the	the	DET
eurjchem-1234	117	25	percentage	percentage	NOUN
eurjchem-1234	117	26	of	of	ADP
eurjchem-1234	117	27	nominal	nominal	NOUN
eurjchem-1234	117	28	ranged	range	VERB
eurjchem-1234	117	29	from	from	ADP
eurjchem-1234	117	30	98.9	98.9	NUM
eurjchem-1234	117	31	to	to	ADP
eurjchem-1234	117	32	105.5	105.5	NUM
eurjchem-1234	117	33	%	%	NOUN
eurjchem-1234	117	34	.	.	PUNCT
eurjchem-1234	118	1	these	these	DET
eurjchem-1234	118	2	cv	cv	NOUN
eurjchem-1234	118	3	and	and	CCONJ
eurjchem-1234	118	4	percentage	percentage	NOUN
eurjchem-1234	118	5	of	of	ADP
eurjchem-1234	118	6	nominal	nominal	ADJ
eurjchem-1234	118	7	values	value	NOUN
eurjchem-1234	118	8	indicate	indicate	VERB
eurjchem-1234	118	9	reproducibility	reproducibility	NOUN
eurjchem-1234	118	10	and	and	CCONJ
eurjchem-1234	118	11	reliability	reliability	NOUN
eurjchem-1234	118	12	of	of	ADP
eurjchem-1234	118	13	the	the	DET
eurjchem-1234	118	14	uplc‐ms	uplc‐ms	NOUN
eurjchem-1234	118	15	/	/	SYM
eurjchem-1234	118	16	ms	ms	NOUN
eurjchem-1234	118	17	method	method	NOUN
eurjchem-1234	118	18	.	.	PUNCT
eurjchem-1234	119	1	mohammed	mohammed	PROPN
eurjchem-1234	119	2	et	et	PROPN
eurjchem-1234	119	3	al	al	PROPN
eurjchem-1234	119	4	.	.	PUNCT
eurjchem-1234	119	5	/	/	SYM
eurjchem-1234	119	6	european	european	PROPN
eurjchem-1234	119	7	journal	journal	PROPN
eurjchem-1234	119	8	of	of	ADP
eurjchem-1234	119	9	chemistry	chemistry	NOUN
eurjchem-1234	119	10	6	6	NUM
eurjchem-1234	119	11	(	(	PUNCT
eurjchem-1234	119	12	2	2	NUM
eurjchem-1234	119	13	)	)	PUNCT
eurjchem-1234	119	14	(	(	PUNCT
eurjchem-1234	119	15	2015	2015	NUM
eurjchem-1234	119	16	)	)	PUNCT
eurjchem-1234	119	17	178‐182	178‐182	NOUN
eurjchem-1234	119	18	181	181	NUM
eurjchem-1234	119	19	table	table	NOUN
eurjchem-1234	119	20	2	2	NUM
eurjchem-1234	119	21	.	.	X
eurjchem-1234	119	22	precision	precision	NOUN
eurjchem-1234	119	23	for	for	ADP
eurjchem-1234	119	24	the	the	DET
eurjchem-1234	119	25	determination	determination	NOUN
eurjchem-1234	119	26	of	of	ADP
eurjchem-1234	119	27	metformin	metformin	NOUN
eurjchem-1234	119	28	hydrochloride	hydrochloride	NOUN
eurjchem-1234	119	29	and	and	CCONJ
eurjchem-1234	119	30	in	in	ADP
eurjchem-1234	119	31	human	human	ADJ
eurjchem-1234	119	32	plasma	plasma	NOUN
eurjchem-1234	119	33	.	.	PUNCT
eurjchem-1234	120	1	added	add	VERB
eurjchem-1234	120	2	concentration	concentration	NOUN
eurjchem-1234	120	3	of	of	ADP
eurjchem-1234	120	4	metformin	metformin	NOUN
eurjchem-1234	120	5	hydrochloride	hydrochloride	NOUN
eurjchem-1234	120	6	(	(	PUNCT
eurjchem-1234	120	7	ng	ng	NOUN
eurjchem-1234	120	8	/	/	SYM
eurjchem-1234	120	9	ml	ml	PROPN
eurjchem-1234	120	10	)	)	PUNCT
eurjchem-1234	120	11	cv	cv	PROPN
eurjchem-1234	120	12	(	(	PUNCT
eurjchem-1234	120	13	%	%	NOUN
eurjchem-1234	120	14	)	)	PUNCT
eurjchem-1234	120	15	a	a	DET
eurjchem-1234	120	16	intra‐day	intra‐day	NOUN
eurjchem-1234	120	17	inter‐day	inter‐day	NOUN
eurjchem-1234	120	18	10.00	10.00	NUM
eurjchem-1234	120	19	2.1	2.1	NUM
eurjchem-1234	120	20	1.5	1.5	NUM
eurjchem-1234	120	21	2000.00	2000.00	NUM
eurjchem-1234	120	22	0.9	0.9	NUM
eurjchem-1234	120	23	0.4	0.4	NUM
eurjchem-1234	120	24	4000.00	4000.00	NUM
eurjchem-1234	120	25	1.3	1.3	NUM
eurjchem-1234	120	26	2.0	2.0	NUM
eurjchem-1234	120	27	a	a	DET
eurjchem-1234	120	28	cv	cv	PROPN
eurjchem-1234	120	29	,	,	PUNCT
eurjchem-1234	120	30	coefficient	coefficient	NOUN
eurjchem-1234	120	31	of	of	ADP
eurjchem-1234	120	32	variation	variation	NOUN
eurjchem-1234	120	33	.	.	PUNCT
eurjchem-1234	121	1	table	table	NOUN
eurjchem-1234	121	2	3	3	NUM
eurjchem-1234	121	3	.	.	PUNCT
eurjchem-1234	122	1	stability	stability	NOUN
eurjchem-1234	122	2	of	of	ADP
eurjchem-1234	122	3	metformin	metformin	NOUN
eurjchem-1234	122	4	hydrochloride	hydrochloride	NOUN
eurjchem-1234	122	5	in	in	ADP
eurjchem-1234	122	6	human	human	ADJ
eurjchem-1234	122	7	plasma	plasma	NOUN
eurjchem-1234	122	8	,	,	PUNCT
eurjchem-1234	122	9	n	n	NOUN
eurjchem-1234	122	10	=	=	SYM
eurjchem-1234	122	11	6	6	NUM
eurjchem-1234	122	12	.	.	PUNCT
eurjchem-1234	122	13	storage	storage	NOUN
eurjchem-1234	122	14	stability	stability	NOUN
eurjchem-1234	122	15	conditions	condition	NOUN
eurjchem-1234	122	16	statistical	statistical	ADJ
eurjchem-1234	122	17	parameters	parameter	NOUN
eurjchem-1234	122	18	metformin	metformin	NOUN
eurjchem-1234	122	19	,	,	PUNCT
eurjchem-1234	122	20	ng	ng	PROPN
eurjchem-1234	122	21	/	/	SYM
eurjchem-1234	122	22	ml	ml	PROPN
eurjchem-1234	122	23	10.000	10.000	NUM
eurjchem-1234	122	24	2000.00	2000.00	NUM
eurjchem-1234	122	25	4000.00	4000.00	NUM
eurjchem-1234	122	26	bench	bench	NOUN
eurjchem-1234	122	27	top	top	ADJ
eurjchem-1234	122	28	stability	stability	NOUN
eurjchem-1234	122	29	(	(	PUNCT
eurjchem-1234	122	30	8	8	NUM
eurjchem-1234	122	31	h	h	NOUN
eurjchem-1234	122	32	)	)	PUNCT
eurjchem-1234	122	33	found	find	VERB
eurjchem-1234	122	34	mean	mean	ADJ
eurjchem-1234	122	35	plasma	plasma	NOUN
eurjchem-1234	122	36	conc	conc	NOUN
eurjchem-1234	122	37	.	.	PUNCT
eurjchem-1234	123	1	9.93	9.93	NUM
eurjchem-1234	123	2	2049.00	2049.00	NUM
eurjchem-1234	123	3	4071.20	4071.20	NUM
eurjchem-1234	123	4	sd	sd	ADP
eurjchem-1234	123	5	a	a	DET
eurjchem-1234	123	6	0.35	0.35	NUM
eurjchem-1234	123	7	24.79	24.79	NUM
eurjchem-1234	123	8	85.50	85.50	NUM
eurjchem-1234	123	9	cv	cv	PROPN
eurjchem-1234	123	10	b	b	PROPN
eurjchem-1234	123	11	3.52	3.52	NUM
eurjchem-1234	123	12	1.21	1.21	NUM
eurjchem-1234	123	13	2.10	2.10	NUM
eurjchem-1234	123	14	percentage	percentage	NOUN
eurjchem-1234	123	15	of	of	ADP
eurjchem-1234	123	16	nominal	nominal	ADJ
eurjchem-1234	123	17	99.31	99.31	NUM
eurjchem-1234	123	18	102.45	102.45	NUM
eurjchem-1234	123	19	101.78	101.78	NUM
eurjchem-1234	123	20	three	three	NUM
eurjchem-1234	123	21	freeze‐thaw	freeze‐thaw	NOUN
eurjchem-1234	123	22	cycles	cycle	NOUN
eurjchem-1234	123	23	found	find	VERB
eurjchem-1234	123	24	mean	mean	ADJ
eurjchem-1234	123	25	plasma	plasma	NOUN
eurjchem-1234	123	26	conc	conc	NOUN
eurjchem-1234	123	27	.	.	PUNCT
eurjchem-1234	124	1	10.15	10.15	NUM
eurjchem-1234	124	2	1989.20	1989.20	NUM
eurjchem-1234	124	3	4084.80	4084.80	NUM
eurjchem-1234	124	4	sd	sd	ADP
eurjchem-1234	124	5	a	a	DET
eurjchem-1234	124	6	0.152	0.152	NUM
eurjchem-1234	124	7	39.78	39.78	NUM
eurjchem-1234	124	8	52.00	52.00	NUM
eurjchem-1234	124	9	cv	cv	PROPN
eurjchem-1234	124	10	b	b	PROPN
eurjchem-1234	124	11	1.50	1.50	NUM
eurjchem-1234	124	12	2.00	2.00	NUM
eurjchem-1234	124	13	1.30	1.30	NUM
eurjchem-1234	124	14	percentage	percentage	NOUN
eurjchem-1234	124	15	of	of	ADP
eurjchem-1234	124	16	nominal	nominal	ADJ
eurjchem-1234	124	17	101.52	101.52	NUM
eurjchem-1234	124	18	99.46	99.46	NUM
eurjchem-1234	124	19	102.12	102.12	NUM
eurjchem-1234	124	20	long‐term	long‐term	NOUN
eurjchem-1234	124	21	stability	stability	NOUN
eurjchem-1234	124	22	(	(	PUNCT
eurjchem-1234	124	23	30	30	NUM
eurjchem-1234	124	24	days	day	NOUN
eurjchem-1234	124	25	)	)	PUNCT
eurjchem-1234	124	26	found	find	VERB
eurjchem-1234	124	27	mean	mean	ADJ
eurjchem-1234	124	28	plasma	plasma	NOUN
eurjchem-1234	124	29	conc	conc	NOUN
eurjchem-1234	124	30	.	.	PUNCT
eurjchem-1234	125	1	11.02	11.02	NUM
eurjchem-1234	125	2	2110.60	2110.60	NUM
eurjchem-1234	125	3	4338.80	4338.80	NUM
eurjchem-1234	125	4	sd	sd	ADP
eurjchem-1234	125	5	a	a	DET
eurjchem-1234	125	6	0.69	0.69	NUM
eurjchem-1234	125	7	45.00	45.00	NUM
eurjchem-1234	125	8	160.97	160.97	NUM
eurjchem-1234	125	9	cv	cv	PROPN
eurjchem-1234	125	10	b	b	PROPN
eurjchem-1234	125	11	6.25	6.25	NUM
eurjchem-1234	125	12	2.13	2.13	NUM
eurjchem-1234	125	13	3.71	3.71	NUM
eurjchem-1234	125	14	percentage	percentage	NOUN
eurjchem-1234	125	15	of	of	ADP
eurjchem-1234	125	16	nominal	nominal	ADJ
eurjchem-1234	125	17	110.21	110.21	NUM
eurjchem-1234	125	18	105.53	105.53	NUM
eurjchem-1234	125	19	108.47	108.47	NUM
eurjchem-1234	125	20	a	a	DET
eurjchem-1234	125	21	sd	sd	NOUN
eurjchem-1234	125	22	,	,	PUNCT
eurjchem-1234	125	23	standard	standard	ADJ
eurjchem-1234	125	24	deviation	deviation	NOUN
eurjchem-1234	125	25	.	.	PUNCT
eurjchem-1234	126	1	b	b	X
eurjchem-1234	126	2	cv	cv	PROPN
eurjchem-1234	126	3	,	,	PUNCT
eurjchem-1234	126	4	coefficient	coefficient	NOUN
eurjchem-1234	126	5	of	of	ADP
eurjchem-1234	126	6	variation	variation	NOUN
eurjchem-1234	126	7	.	.	PUNCT
eurjchem-1234	127	1	table	table	NOUN
eurjchem-1234	127	2	4	4	NUM
eurjchem-1234	127	3	.	.	NOUN
eurjchem-1234	127	4	pharmacokinetics	pharmacokinetic	NOUN
eurjchem-1234	127	5	parameters	parameter	NOUN
eurjchem-1234	127	6	of	of	ADP
eurjchem-1234	127	7	metformin	metformin	PROPN
eurjchem-1234	127	8	hydrochloride	hydrochloride	NOUN
eurjchem-1234	127	9	after	after	ADP
eurjchem-1234	127	10	administration	administration	NOUN
eurjchem-1234	127	11	of	of	ADP
eurjchem-1234	127	12	single	single	ADJ
eurjchem-1234	127	13	oral	oral	ADJ
eurjchem-1234	127	14	dose	dose	NOUN
eurjchem-1234	127	15	of	of	ADP
eurjchem-1234	127	16	mepaphage	mepaphage	NOUN
eurjchem-1234	127	17	500	500	NUM
eurjchem-1234	127	18	mg	mg	PROPN
eurjchem-1234	127	19	tablet	tablet	NOUN
eurjchem-1234	127	20	,	,	PUNCT
eurjchem-1234	127	21	the	the	DET
eurjchem-1234	127	22	test	test	NOUN
eurjchem-1234	127	23	product	product	NOUN
eurjchem-1234	127	24	(	(	PUNCT
eurjchem-1234	127	25	mepaco	mepaco	PROPN
eurjchem-1234	127	26	,	,	PUNCT
eurjchem-1234	127	27	egypt	egypt	PROPN
eurjchem-1234	127	28	.	.	PUNCT
eurjchem-1234	127	29	)	)	PUNCT
eurjchem-1234	128	1	and	and	CCONJ
eurjchem-1234	128	2	glucophage	glucophage	NOUN
eurjchem-1234	128	3	500	500	NUM
eurjchem-1234	128	4	mg	mg	NOUN
eurjchem-1234	128	5	tablet	tablet	NOUN
eurjchem-1234	128	6	,	,	PUNCT
eurjchem-1234	128	7	the	the	DET
eurjchem-1234	128	8	reference	reference	NOUN
eurjchem-1234	128	9	product	product	NOUN
eurjchem-1234	128	10	(	(	PUNCT
eurjchem-1234	128	11	merck	merck	PROPN
eurjchem-1234	128	12	sante	sante	PROPN
eurjchem-1234	128	13	,	,	PUNCT
eurjchem-1234	128	14	s.a.s	s.a.s	PROPN
eurjchem-1234	128	15	.	.	PROPN
eurjchem-1234	128	16	,	,	PUNCT
eurjchem-1234	128	17	france	france	PROPN
eurjchem-1234	128	18	)	)	PUNCT
eurjchem-1234	128	19	.	.	PUNCT
eurjchem-1234	129	1	phramacokinetic	phramacokinetic	ADJ
eurjchem-1234	129	2	parameter	parameter	NOUN
eurjchem-1234	129	3	mepaphage	mepaphage	NOUN
eurjchem-1234	129	4	(	(	PUNCT
eurjchem-1234	129	5	test	test	NOUN
eurjchem-1234	129	6	drug	drug	NOUN
eurjchem-1234	129	7	)	)	PUNCT
eurjchem-1234	129	8	(	(	PUNCT
eurjchem-1234	129	9	mean±sd	mean±sd	NOUN
eurjchem-1234	129	10	)	)	PUNCT
eurjchem-1234	129	11	glucophage	glucophage	NOUN
eurjchem-1234	129	12	(	(	PUNCT
eurjchem-1234	129	13	reference	reference	NOUN
eurjchem-1234	129	14	drug	drug	NOUN
eurjchem-1234	129	15	)	)	PUNCT
eurjchem-1234	129	16	(	(	PUNCT
eurjchem-1234	129	17	mean±sd	mean±sd	NOUN
eurjchem-1234	129	18	)	)	PUNCT
eurjchem-1234	129	19	auc0‐t	auc0‐t	NOUN
eurjchem-1234	129	20	(	(	PUNCT
eurjchem-1234	129	21	ng.h	ng.h	NOUN
eurjchem-1234	129	22	/	/	SYM
eurjchem-1234	129	23	ml	ml	NOUN
eurjchem-1234	129	24	)	)	PUNCT
eurjchem-1234	129	25	4595±2070	4595±2070	PROPN
eurjchem-1234	130	1	4837±2794	4837±2794	PROPN
eurjchem-1234	130	2	auc0‐∞	auc0‐∞	PROPN
eurjchem-1234	130	3	(	(	PUNCT
eurjchem-1234	130	4	ng.h	ng.h	NOUN
eurjchem-1234	130	5	/	/	SYM
eurjchem-1234	130	6	ml	ml	NOUN
eurjchem-1234	130	7	)	)	PUNCT
eurjchem-1234	130	8	4808±2115	4808±2115	PROPN
eurjchem-1234	131	1	5079±2840	5079±2840	PROPN
eurjchem-1234	131	2	cmax	cmax	NOUN
eurjchem-1234	131	3	(	(	PUNCT
eurjchem-1234	131	4	ng	ng	NOUN
eurjchem-1234	131	5	/	/	SYM
eurjchem-1234	131	6	ml	ml	NOUN
eurjchem-1234	131	7	)	)	PUNCT
eurjchem-1234	131	8	711±429	711±429	PROPN
eurjchem-1234	131	9	747±557	747±557	NUM
eurjchem-1234	131	10	tmax	tmax	ADP
eurjchem-1234	131	11	(	(	PUNCT
eurjchem-1234	131	12	h	h	NOUN
eurjchem-1234	131	13	)	)	PUNCT
eurjchem-1234	131	14	(	(	PUNCT
eurjchem-1234	131	15	median	median	PROPN
eurjchem-1234	131	16	)	)	PUNCT
eurjchem-1234	131	17	2.5	2.5	NUM
eurjchem-1234	131	18	2.5	2.5	NUM
eurjchem-1234	131	19	kel	kel	NOUN
eurjchem-1234	131	20	(	(	PUNCT
eurjchem-1234	131	21	h‐1	h‐1	PROPN
eurjchem-1234	131	22	)	)	PUNCT
eurjchem-1234	131	23	0.115±0.045	0.115±0.045	NOUN
eurjchem-1234	131	24	0.12±0.051	0.12±0.051	PUNCT
eurjchem-1234	131	25	t1/2	t1/2	ADJ
eurjchem-1234	131	26	(	(	PUNCT
eurjchem-1234	131	27	h	h	NOUN
eurjchem-1234	131	28	)	)	PUNCT
eurjchem-1234	131	29	7.12±3.3	7.12±3.3	NUM
eurjchem-1234	131	30	7.27±3.95	7.27±3.95	NUM
eurjchem-1234	131	31	3.3.4	3.3.4	NUM
eurjchem-1234	131	32	.	.	PUNCT
eurjchem-1234	131	33	recovery	recovery	NOUN
eurjchem-1234	131	34	the	the	DET
eurjchem-1234	131	35	extraction	extraction	NOUN
eurjchem-1234	131	36	recovery	recovery	NOUN
eurjchem-1234	131	37	was	be	AUX
eurjchem-1234	131	38	determined	determine	VERB
eurjchem-1234	131	39	by	by	ADP
eurjchem-1234	131	40	comparing	compare	VERB
eurjchem-1234	131	41	the	the	DET
eurjchem-1234	131	42	peak	peak	NOUN
eurjchem-1234	131	43	areas	area	NOUN
eurjchem-1234	131	44	of	of	ADP
eurjchem-1234	131	45	extracted	extract	VERB
eurjchem-1234	131	46	plasma	plasma	NOUN
eurjchem-1234	131	47	qc	qc	PROPN
eurjchem-1234	131	48	samples	sample	NOUN
eurjchem-1234	131	49	at	at	ADP
eurjchem-1234	131	50	10	10	NUM
eurjchem-1234	131	51	,	,	PUNCT
eurjchem-1234	131	52	2000	2000	NUM
eurjchem-1234	131	53	and	and	CCONJ
eurjchem-1234	131	54	4000	4000	NUM
eurjchem-1234	131	55	ng	ng	NOUN
eurjchem-1234	131	56	/	/	SYM
eurjchem-1234	131	57	ml	ml	PROPN
eurjchem-1234	131	58	levels	level	NOUN
eurjchem-1234	131	59	to	to	ADP
eurjchem-1234	131	60	the	the	DET
eurjchem-1234	131	61	peak	peak	NOUN
eurjchem-1234	131	62	areas	area	NOUN
eurjchem-1234	131	63	of	of	ADP
eurjchem-1234	131	64	metformin	metformin	NOUN
eurjchem-1234	131	65	hydrochloride	hydrochloride	NOUN
eurjchem-1234	131	66	in	in	ADP
eurjchem-1234	131	67	solvent	solvent	NOUN
eurjchem-1234	131	68	at	at	ADP
eurjchem-1234	131	69	the	the	DET
eurjchem-1234	131	70	corresponding	corresponding	ADJ
eurjchem-1234	131	71	concentrations	concentration	NOUN
eurjchem-1234	131	72	.	.	PUNCT
eurjchem-1234	132	1	the	the	DET
eurjchem-1234	132	2	average	average	ADJ
eurjchem-1234	132	3	recovery	recovery	NOUN
eurjchem-1234	132	4	for	for	ADP
eurjchem-1234	132	5	metformin	metformin	NOUN
eurjchem-1234	132	6	hydrochloride	hydrochloride	NOUN
eurjchem-1234	132	7	was	be	AUX
eurjchem-1234	132	8	97.0	97.0	NUM
eurjchem-1234	132	9	%	%	NOUN
eurjchem-1234	132	10	.	.	PUNCT
eurjchem-1234	133	1	3.3.5	3.3.5	X
eurjchem-1234	133	2	.	.	PUNCT
eurjchem-1234	134	1	stability	stability	NOUN
eurjchem-1234	134	2	of	of	ADP
eurjchem-1234	134	3	the	the	DET
eurjchem-1234	134	4	analyte	analyte	NOUN
eurjchem-1234	134	5	stock	stock	NOUN
eurjchem-1234	134	6	solution	solution	NOUN
eurjchem-1234	134	7	of	of	ADP
eurjchem-1234	134	8	analyte	analyte	NOUN
eurjchem-1234	134	9	and	and	CCONJ
eurjchem-1234	134	10	is	be	AUX
eurjchem-1234	134	11	were	be	AUX
eurjchem-1234	134	12	stable	stable	ADJ
eurjchem-1234	134	13	at	at	ADP
eurjchem-1234	134	14	room	room	NOUN
eurjchem-1234	134	15	temperature	temperature	NOUN
eurjchem-1234	134	16	for	for	ADP
eurjchem-1234	134	17	22	22	NUM
eurjchem-1234	134	18	h	h	NOUN
eurjchem-1234	134	19	and	and	CCONJ
eurjchem-1234	134	20	at	at	ADP
eurjchem-1234	134	21	2‐8	2‐8	NOUN
eurjchem-1234	134	22	°	°	ADP
eurjchem-1234	134	23	c	c	NOUN
eurjchem-1234	134	24	for	for	ADP
eurjchem-1234	134	25	30	30	NUM
eurjchem-1234	134	26	days	day	NOUN
eurjchem-1234	134	27	.	.	PUNCT
eurjchem-1234	135	1	the	the	DET
eurjchem-1234	135	2	analyte	analyte	NOUN
eurjchem-1234	135	3	in	in	ADP
eurjchem-1234	135	4	control	control	NOUN
eurjchem-1234	135	5	human	human	ADJ
eurjchem-1234	135	6	plasma	plasma	NOUN
eurjchem-1234	135	7	at	at	ADP
eurjchem-1234	135	8	room	room	NOUN
eurjchem-1234	135	9	temperature	temperature	NOUN
eurjchem-1234	135	10	was	be	AUX
eurjchem-1234	135	11	stable	stable	ADJ
eurjchem-1234	135	12	at	at	ADP
eurjchem-1234	135	13	least	least	ADJ
eurjchem-1234	135	14	for	for	ADP
eurjchem-1234	135	15	8	8	NUM
eurjchem-1234	135	16	h	h	NOUN
eurjchem-1234	135	17	(	(	PUNCT
eurjchem-1234	135	18	bench	bench	VERB
eurjchem-1234	135	19	top	top	ADJ
eurjchem-1234	135	20	stability	stability	NOUN
eurjchem-1234	135	21	)	)	PUNCT
eurjchem-1234	135	22	,	,	PUNCT
eurjchem-1234	135	23	stable	stable	ADJ
eurjchem-1234	135	24	for	for	ADP
eurjchem-1234	135	25	minimum	minimum	NOUN
eurjchem-1234	135	26	of	of	ADP
eurjchem-1234	135	27	three	three	NUM
eurjchem-1234	135	28	freeze	freeze	NOUN
eurjchem-1234	135	29	and	and	CCONJ
eurjchem-1234	135	30	thaw	thaw	NOUN
eurjchem-1234	135	31	cycles	cycle	NOUN
eurjchem-1234	135	32	.	.	PUNCT
eurjchem-1234	136	1	spiked	spiked	ADJ
eurjchem-1234	136	2	plasma	plasma	NOUN
eurjchem-1234	136	3	samples	sample	NOUN
eurjchem-1234	136	4	,	,	PUNCT
eurjchem-1234	136	5	stored	store	VERB
eurjchem-1234	136	6	at	at	ADP
eurjchem-1234	136	7	‐70	‐70	PROPN
eurjchem-1234	136	8	°	°	ADP
eurjchem-1234	136	9	c	c	NOUN
eurjchem-1234	136	10	for	for	ADP
eurjchem-1234	136	11	long	long	ADJ
eurjchem-1234	136	12	term	term	NOUN
eurjchem-1234	136	13	stability	stability	NOUN
eurjchem-1234	136	14	experiment	experiment	NOUN
eurjchem-1234	136	15	,	,	PUNCT
eurjchem-1234	136	16	were	be	AUX
eurjchem-1234	136	17	stable	stable	ADJ
eurjchem-1234	136	18	for	for	ADP
eurjchem-1234	136	19	minimum	minimum	NOUN
eurjchem-1234	136	20	of	of	ADP
eurjchem-1234	136	21	30	30	NUM
eurjchem-1234	136	22	days	day	NOUN
eurjchem-1234	136	23	.	.	PUNCT
eurjchem-1234	137	1	different	different	ADJ
eurjchem-1234	137	2	stability	stability	NOUN
eurjchem-1234	137	3	experiments	experiment	NOUN
eurjchem-1234	137	4	in	in	ADP
eurjchem-1234	137	5	plasma	plasma	NOUN
eurjchem-1234	137	6	with	with	ADP
eurjchem-1234	137	7	values	value	NOUN
eurjchem-1234	137	8	for	for	ADP
eurjchem-1234	137	9	precision	precision	NOUN
eurjchem-1234	137	10	and	and	CCONJ
eurjchem-1234	137	11	percent	percent	NOUN
eurjchem-1234	137	12	change	change	NOUN
eurjchem-1234	137	13	are	be	AUX
eurjchem-1234	137	14	shown	show	VERB
eurjchem-1234	137	15	in	in	ADP
eurjchem-1234	137	16	table	table	NOUN
eurjchem-1234	137	17	3	3	NUM
eurjchem-1234	137	18	.	.	NOUN
eurjchem-1234	137	19	3.4	3.4	NUM
eurjchem-1234	137	20	.	.	PUNCT
eurjchem-1234	138	1	bioequivalence	bioequivalence	NOUN
eurjchem-1234	138	2	study	study	VERB
eurjchem-1234	138	3	the	the	DET
eurjchem-1234	138	4	present	present	ADJ
eurjchem-1234	138	5	method	method	NOUN
eurjchem-1234	138	6	was	be	AUX
eurjchem-1234	138	7	successfully	successfully	ADV
eurjchem-1234	138	8	applied	apply	VERB
eurjchem-1234	138	9	to	to	ADP
eurjchem-1234	138	10	a	a	DET
eurjchem-1234	138	11	bioequivalence	bioequivalence	NOUN
eurjchem-1234	138	12	study	study	NOUN
eurjchem-1234	138	13	of	of	ADP
eurjchem-1234	138	14	metformin	metformin	PROPN
eurjchem-1234	138	15	hydrochloride	hydrochloride	NOUN
eurjchem-1234	138	16	after	after	ADP
eurjchem-1234	138	17	oral	oral	ADJ
eurjchem-1234	138	18	administration	administration	NOUN
eurjchem-1234	138	19	of	of	ADP
eurjchem-1234	138	20	two	two	NUM
eurjchem-1234	138	21	brands	brand	NOUN
eurjchem-1234	138	22	of	of	ADP
eurjchem-1234	138	23	metformin	metformin	NOUN
eurjchem-1234	138	24	hydrochloride	hydrochloride	NOUN
eurjchem-1234	138	25	(	(	PUNCT
eurjchem-1234	138	26	mepaphage	mepaphage	NOUN
eurjchem-1234	138	27	500	500	NUM
eurjchem-1234	138	28	mg	mg	NOUN
eurjchem-1234	138	29	tablet	tablet	NOUN
eurjchem-1234	138	30	mepaco	mepaco	PROPN
eurjchem-1234	138	31	,	,	PUNCT
eurjchem-1234	138	32	elsharkya	elsharkya	NOUN
eurjchem-1234	138	33	,	,	PUNCT
eurjchem-1234	138	34	egypt	egypt	PROPN
eurjchem-1234	138	35	and	and	CCONJ
eurjchem-1234	138	36	glucophage	glucophage	NOUN
eurjchem-1234	139	1	500	500	NUM
eurjchem-1234	139	2	mg	mg	NOUN
eurjchem-1234	139	3	film	film	NOUN
eurjchem-1234	139	4	coated	coat	VERB
eurjchem-1234	139	5	tablet	tablet	PROPN
eurjchem-1234	139	6	merck	merck	PROPN
eurjchem-1234	139	7	sante	sante	PROPN
eurjchem-1234	139	8	s.a.s	s.a.s	PROPN
eurjchem-1234	139	9	.	.	PROPN
eurjchem-1234	139	10	,	,	PUNCT
eurjchem-1234	139	11	france	france	PROPN
eurjchem-1234	139	12	)	)	PUNCT
eurjchem-1234	139	13	in	in	ADP
eurjchem-1234	139	14	24	24	NUM
eurjchem-1234	139	15	healthy	healthy	ADJ
eurjchem-1234	139	16	volunteers	volunteer	NOUN
eurjchem-1234	139	17	.	.	PUNCT
eurjchem-1234	140	1	mean	mean	VERB
eurjchem-1234	140	2	plasma	plasma	NOUN
eurjchem-1234	140	3	concentration‐	concentration‐	ADJ
eurjchem-1234	140	4	time	time	NOUN
eurjchem-1234	140	5	curves	curve	NOUN
eurjchem-1234	140	6	of	of	ADP
eurjchem-1234	140	7	metformin	metformin	NOUN
eurjchem-1234	140	8	hydrochloride	hydrochloride	NOUN
eurjchem-1234	140	9	in	in	ADP
eurjchem-1234	140	10	a	a	DET
eurjchem-1234	140	11	single	single	ADJ
eurjchem-1234	140	12	dose	dose	NOUN
eurjchem-1234	140	13	study	study	NOUN
eurjchem-1234	140	14	are	be	AUX
eurjchem-1234	140	15	shown	show	VERB
eurjchem-1234	140	16	in	in	ADP
eurjchem-1234	140	17	figure	figure	NOUN
eurjchem-1234	140	18	3	3	NUM
eurjchem-1234	140	19	.	.	PUNCT
eurjchem-1234	141	1	bioequivalence	bioequivalence	NOUN
eurjchem-1234	141	2	criteria	criterion	NOUN
eurjchem-1234	141	3	were	be	AUX
eurjchem-1234	141	4	met	meet	VERB
eurjchem-1234	141	5	for	for	ADP
eurjchem-1234	141	6	the	the	DET
eurjchem-1234	141	7	mepaphage	mepaphage	NOUN
eurjchem-1234	141	8	500	500	NUM
eurjchem-1234	141	9	mg	mg	NOUN
eurjchem-1234	141	10	tablet	tablet	NOUN
eurjchem-1234	141	11	formulation	formulation	NOUN
eurjchem-1234	141	12	relative	relative	ADJ
eurjchem-1234	141	13	to	to	ADP
eurjchem-1234	141	14	the	the	DET
eurjchem-1234	141	15	glucophage	glucophage	NOUN
eurjchem-1234	141	16	500	500	NUM
eurjchem-1234	141	17	mg	mg	NOUN
eurjchem-1234	141	18	film	film	NOUN
eurjchem-1234	141	19	coated	coat	VERB
eurjchem-1234	141	20	tablet	tablet	NOUN
eurjchem-1234	141	21	formulation	formulation	NOUN
eurjchem-1234	141	22	as	as	ADP
eurjchem-1234	141	23	the	the	DET
eurjchem-1234	141	24	corresponding	corresponding	ADJ
eurjchem-1234	141	25	94.7	94.7	NUM
eurjchem-1234	141	26	%	%	NOUN
eurjchem-1234	141	27	.	.	PUNCT
eurjchem-1234	142	1	the	the	DET
eurjchem-1234	142	2	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-1234	142	3	parameters	parameter	NOUN
eurjchem-1234	142	4	are	be	AUX
eurjchem-1234	142	5	shown	show	VERB
eurjchem-1234	142	6	in	in	ADP
eurjchem-1234	142	7	table	table	NOUN
eurjchem-1234	142	8	4	4	NUM
eurjchem-1234	142	9	.	.	NOUN
eurjchem-1234	143	1	4	4	NUM
eurjchem-1234	143	2	.	.	X
eurjchem-1234	143	3	conclusion	conclusion	NOUN
eurjchem-1234	143	4	a	a	DET
eurjchem-1234	143	5	relatively	relatively	ADV
eurjchem-1234	143	6	simple	simple	ADJ
eurjchem-1234	143	7	,	,	PUNCT
eurjchem-1234	143	8	accurate	accurate	ADJ
eurjchem-1234	143	9	,	,	PUNCT
eurjchem-1234	143	10	precise	precise	ADJ
eurjchem-1234	143	11	and	and	CCONJ
eurjchem-1234	143	12	rapid	rapid	ADJ
eurjchem-1234	143	13	method	method	NOUN
eurjchem-1234	143	14	suitable	suitable	ADJ
eurjchem-1234	143	15	for	for	ADP
eurjchem-1234	143	16	the	the	DET
eurjchem-1234	143	17	determination	determination	NOUN
eurjchem-1234	143	18	of	of	ADP
eurjchem-1234	143	19	metformin	metformin	NOUN
eurjchem-1234	143	20	hydrochloride	hydrochloride	NOUN
eurjchem-1234	143	21	in	in	ADP
eurjchem-1234	143	22	plasma	plasma	NOUN
eurjchem-1234	143	23	for	for	ADP
eurjchem-1234	143	24	bioequivalence	bioequivalence	NOUN
eurjchem-1234	143	25	studies	study	NOUN
eurjchem-1234	143	26	was	be	AUX
eurjchem-1234	143	27	developed	develop	VERB
eurjchem-1234	143	28	and	and	CCONJ
eurjchem-1234	143	29	validated	validate	VERB
eurjchem-1234	143	30	.	.	PUNCT
eurjchem-1234	144	1	this	this	DET
eurjchem-1234	144	2	method	method	NOUN
eurjchem-1234	144	3	has	have	VERB
eurjchem-1234	144	4	several	several	ADJ
eurjchem-1234	144	5	advantages	advantage	NOUN
eurjchem-1234	144	6	compared	compare	VERB
eurjchem-1234	144	7	to	to	ADP
eurjchem-1234	144	8	previously	previously	ADV
eurjchem-1234	144	9	reported	report	VERB
eurjchem-1234	144	10	methods	method	NOUN
eurjchem-1234	144	11	such	such	ADJ
eurjchem-1234	144	12	as	as	ADP
eurjchem-1234	144	13	using	use	VERB
eurjchem-1234	144	14	of	of	ADP
eurjchem-1234	144	15	uplc	uplc	ADJ
eurjchem-1234	144	16	column	column	NOUN
eurjchem-1234	144	17	,	,	PUNCT
eurjchem-1234	144	18	reducing	reduce	VERB
eurjchem-1234	144	19	flow	flow	NOUN
eurjchem-1234	144	20	rate	rate	NOUN
eurjchem-1234	144	21	and	and	CCONJ
eurjchem-1234	144	22	consequently	consequently	ADV
eurjchem-1234	144	23	decreased	decrease	VERB
eurjchem-1234	144	24	the	the	DET
eurjchem-1234	144	25	volume	volume	NOUN
eurjchem-1234	144	26	of	of	ADP
eurjchem-1234	144	27	organic	organic	ADJ
eurjchem-1234	144	28	solvent	solvent	NOUN
eurjchem-1234	144	29	used	use	VERB
eurjchem-1234	144	30	in	in	ADP
eurjchem-1234	144	31	the	the	DET
eurjchem-1234	144	32	mobile	mobile	ADJ
eurjchem-1234	144	33	phase	phase	NOUN
eurjchem-1234	144	34	and	and	CCONJ
eurjchem-1234	144	35	time	time	NOUN
eurjchem-1234	144	36	of	of	ADP
eurjchem-1234	144	37	analysis	analysis	NOUN
eurjchem-1234	144	38	(	(	PUNCT
eurjchem-1234	144	39	about	about	ADV
eurjchem-1234	144	40	0.5	0.5	NUM
eurjchem-1234	144	41	min	min	NOUN
eurjchem-1234	144	42	)	)	PUNCT
eurjchem-1234	144	43	.	.	PUNCT
eurjchem-1234	145	1	in	in	ADP
eurjchem-1234	145	2	addition	addition	NOUN
eurjchem-1234	145	3	,	,	PUNCT
eurjchem-1234	145	4	the	the	DET
eurjchem-1234	145	5	method	method	NOUN
eurjchem-1234	145	6	was	be	AUX
eurjchem-1234	145	7	comparatively	comparatively	ADV
eurjchem-1234	145	8	simple	simple	ADJ
eurjchem-1234	145	9	,	,	PUNCT
eurjchem-1234	145	10	due	due	ADP
eurjchem-1234	145	11	to	to	ADP
eurjchem-1234	145	12	the	the	DET
eurjchem-1234	145	13	use	use	NOUN
eurjchem-1234	145	14	of	of	ADP
eurjchem-1234	145	15	direct	direct	ADJ
eurjchem-1234	145	16	solvent	solvent	NOUN
eurjchem-1234	145	17	extraction	extraction	NOUN
eurjchem-1234	145	18	and	and	CCONJ
eurjchem-1234	145	19	provided	provide	VERB
eurjchem-1234	145	20	accuracy	accuracy	NOUN
eurjchem-1234	145	21	and	and	CCONJ
eurjchem-1234	145	22	precision	precision	NOUN
eurjchem-1234	145	23	,	,	PUNCT
eurjchem-1234	145	24	which	which	PRON
eurjchem-1234	145	25	was	be	AUX
eurjchem-1234	145	26	better	well	ADJ
eurjchem-1234	145	27	than	than	ADP
eurjchem-1234	145	28	most	most	ADV
eurjchem-1234	145	29	previously	previously	ADV
eurjchem-1234	145	30	reported	report	VERB
eurjchem-1234	145	31	methods	method	NOUN
eurjchem-1234	145	32	.	.	PUNCT
eurjchem-1234	146	1	the	the	DET
eurjchem-1234	146	2	current	current	ADJ
eurjchem-1234	146	3	relatively	relatively	ADV
eurjchem-1234	146	4	very	very	ADV
eurjchem-1234	146	5	short	short	ADJ
eurjchem-1234	146	6	run	run	NOUN
eurjchem-1234	146	7	time	time	NOUN
eurjchem-1234	146	8	of	of	ADP
eurjchem-1234	146	9	0.5	0.5	NUM
eurjchem-1234	146	10	min	min	NOUN
eurjchem-1234	146	11	.	.	PROPN
eurjchem-1234	146	12	has	have	VERB
eurjchem-1234	146	13	the	the	DET
eurjchem-1234	146	14	advantage	advantage	NOUN
eurjchem-1234	146	15	of	of	ADP
eurjchem-1234	146	16	facilitating	facilitate	VERB
eurjchem-1234	146	17	and	and	CCONJ
eurjchem-1234	146	18	enhancing	enhance	VERB
eurjchem-1234	146	19	the	the	DET
eurjchem-1234	146	20	efficiency	efficiency	NOUN
eurjchem-1234	146	21	of	of	ADP
eurjchem-1234	146	22	processing	process	VERB
eurjchem-1234	146	23	large	large	ADJ
eurjchem-1234	146	24	numbers	number	NOUN
eurjchem-1234	146	25	of	of	ADP
eurjchem-1234	146	26	plasma	plasma	NOUN
eurjchem-1234	146	27	samples	sample	NOUN
eurjchem-1234	146	28	obtained	obtain	VERB
eurjchem-1234	146	29	from	from	ADP
eurjchem-1234	146	30	bioequivalence	bioequivalence	NOUN
eurjchem-1234	146	31	studies	study	NOUN
eurjchem-1234	146	32	in	in	ADP
eurjchem-1234	146	33	healthy	healthy	ADJ
eurjchem-1234	146	34	human	human	ADJ
eurjchem-1234	146	35	subjects	subject	NOUN
eurjchem-1234	146	36	.	.	PUNCT
eurjchem-1234	147	1	figure	figure	VERB
eurjchem-1234	147	2	3	3	NUM
eurjchem-1234	147	3	.	.	PUNCT
eurjchem-1234	148	1	mean	mean	VERB
eurjchem-1234	148	2	plasma	plasma	NOUN
eurjchem-1234	148	3	concentration	concentration	NOUN
eurjchem-1234	148	4	of	of	ADP
eurjchem-1234	148	5	metformin	metformin	NOUN
eurjchem-1234	148	6	after	after	ADP
eurjchem-1234	148	7	administration	administration	NOUN
eurjchem-1234	148	8	of	of	ADP
eurjchem-1234	148	9	single	single	ADJ
eurjchem-1234	148	10	oral	oral	ADJ
eurjchem-1234	148	11	dose	dose	NOUN
eurjchem-1234	148	12	of	of	ADP
eurjchem-1234	148	13	mepaphage	mepaphage	NOUN
eurjchem-1234	148	14	(	(	PUNCT
eurjchem-1234	148	15	metformin	metformin	NOUN
eurjchem-1234	148	16	hydrochloride	hydrochloride	NOUN
eurjchem-1234	148	17	)	)	PUNCT
eurjchem-1234	148	18	500	500	NUM
eurjchem-1234	148	19	mg	mg	NOUN
eurjchem-1234	148	20	film	film	NOUN
eurjchem-1234	148	21	coated	coat	VERB
eurjchem-1234	148	22	tablet	tablet	NOUN
eurjchem-1234	148	23	,	,	PUNCT
eurjchem-1234	148	24	the	the	DET
eurjchem-1234	148	25	test	test	NOUN
eurjchem-1234	148	26	product	product	NOUN
eurjchem-1234	148	27	(	(	PUNCT
eurjchem-1234	148	28	mepaco	mepaco	PROPN
eurjchem-1234	148	29	,	,	PUNCT
eurjchem-1234	148	30	elsharkya	elsharkya	NOUN
eurjchem-1234	148	31	,	,	PUNCT
eurjchem-1234	148	32	egypt	egypt	PROPN
eurjchem-1234	148	33	)	)	PUNCT
eurjchem-1234	148	34	and	and	CCONJ
eurjchem-1234	148	35	glucophage	glucophage	NOUN
eurjchem-1234	148	36	(	(	PUNCT
eurjchem-1234	148	37	metformin	metformin	NOUN
eurjchem-1234	148	38	hydrochloride	hydrochloride	NOUN
eurjchem-1234	148	39	)	)	PUNCT
eurjchem-1234	148	40	500	500	NUM
eurjchem-1234	148	41	mg	mg	NOUN
eurjchem-1234	148	42	film	film	NOUN
eurjchem-1234	148	43	coated	coat	VERB
eurjchem-1234	148	44	tablet	tablet	NOUN
eurjchem-1234	148	45	,	,	PUNCT
eurjchem-1234	148	46	the	the	DET
eurjchem-1234	148	47	reference	reference	NOUN
eurjchem-1234	148	48	product	product	NOUN
eurjchem-1234	148	49	(	(	PUNCT
eurjchem-1234	148	50	merck	merck	PROPN
eurjchem-1234	148	51	sante	sante	PROPN
eurjchem-1234	148	52	,	,	PUNCT
eurjchem-1234	148	53	s.a.s	s.a.s	PROPN
eurjchem-1234	148	54	.	.	PROPN
eurjchem-1234	148	55	,	,	PUNCT
eurjchem-1234	148	56	france	france	PROPN
eurjchem-1234	148	57	)	)	PUNCT
eurjchem-1234	148	58	in	in	ADP
eurjchem-1234	148	59	24	24	NUM
eurjchem-1234	148	60	healthy	healthy	ADJ
eurjchem-1234	148	61	volunteers	volunteer	NOUN
eurjchem-1234	148	62	.	.	PUNCT
eurjchem-1234	149	1	acknowledgement	acknowledgement	NOUN
eurjchem-1234	149	2	we	we	PRON
eurjchem-1234	149	3	also	also	ADV
eurjchem-1234	149	4	thank	thank	VERB
eurjchem-1234	149	5	mepaco	mepaco	PROPN
eurjchem-1234	149	6	pharmaceutical	pharmaceutical	NOUN
eurjchem-1234	149	7	company	company	NOUN
eurjchem-1234	149	8	(	(	PUNCT
eurjchem-1234	149	9	arab	arab	ADJ
eurjchem-1234	149	10	company	company	NOUN
eurjchem-1234	149	11	for	for	ADP
eurjchem-1234	149	12	pharmaceutical	pharmaceutical	NOUN
eurjchem-1234	149	13	and	and	CCONJ
eurjchem-1234	149	14	medicinal	medicinal	ADJ
eurjchem-1234	149	15	plant	plant	NOUN
eurjchem-1234	149	16	)	)	PUNCT
eurjchem-1234	149	17	,	,	PUNCT
eurjchem-1234	149	18	elsharkya	elsharkya	PROPN
eurjchem-1234	149	19	,	,	PUNCT
eurjchem-1234	149	20	egypt	egypt	PROPN
eurjchem-1234	149	21	for	for	ADP
eurjchem-1234	149	22	donation	donation	NOUN
eurjchem-1234	149	23	of	of	ADP
eurjchem-1234	149	24	the	the	DET
eurjchem-1234	149	25	mepaphage	mepaphage	NOUN
eurjchem-1234	149	26	tablets	tablet	NOUN
eurjchem-1234	149	27	.	.	PUNCT
eurjchem-1234	150	1	182	182	NUM
eurjchem-1234	150	2	mohammed	mohammed	PROPN
eurjchem-1234	150	3	et	et	PROPN
eurjchem-1234	150	4	al	al	PROPN
eurjchem-1234	150	5	.	.	PUNCT
eurjchem-1234	150	6	/	/	SYM
eurjchem-1234	150	7	european	european	PROPN
eurjchem-1234	150	8	journal	journal	PROPN
eurjchem-1234	150	9	of	of	ADP
eurjchem-1234	150	10	chemistry	chemistry	NOUN
eurjchem-1234	150	11	6	6	NUM
eurjchem-1234	150	12	(	(	PUNCT
eurjchem-1234	150	13	2	2	NUM
eurjchem-1234	150	14	)	)	PUNCT
eurjchem-1234	150	15	(	(	PUNCT
eurjchem-1234	150	16	2015	2015	NUM
eurjchem-1234	150	17	)	)	PUNCT
eurjchem-1234	150	18	178‐182	178‐182	NUM
eurjchem-1234	150	19	reference	reference	NOUN
eurjchem-1234	151	1	[	[	X
eurjchem-1234	151	2	1	1	NUM
eurjchem-1234	151	3	]	]	PUNCT
eurjchem-1234	151	4	.	.	PUNCT
eurjchem-1234	152	1	o’neil	o’neil	PROPN
eurjchem-1234	152	2	,	,	PUNCT
eurjchem-1234	152	3	m.	m.	PROPN
eurjchem-1234	152	4	j.	j.	PROPN
eurjchem-1234	152	5	;	;	PUNCT
eurjchem-1234	152	6	heckelman	heckelman	PROPN
eurjchem-1234	152	7	p.	p.	PROPN
eurjchem-1234	152	8	e.	e.	PROPN
eurjchem-1234	152	9	;	;	PUNCT
eurjchem-1234	152	10	koch	koch	PROPN
eurjchem-1234	152	11	c.	c.	PROPN
eurjchem-1234	152	12	b.	b.	PROPN
eurjchem-1234	152	13	;	;	PUNCT
eurjchem-1234	152	14	roman	roman	PROPN
eurjchem-1234	152	15	k.	k.	PROPN
eurjchem-1234	152	16	j.	j.	PROPN
eurjchem-1234	153	1	the	the	DET
eurjchem-1234	153	2	merck	merck	PROPN
eurjchem-1234	153	3	index	index	PROPN
eurjchem-1234	153	4	:	:	PUNCT
eurjchem-1234	153	5	an	an	DET
eurjchem-1234	153	6	encyclopedia	encyclopedia	NOUN
eurjchem-1234	153	7	of	of	ADP
eurjchem-1234	153	8	chemicals	chemical	NOUN
eurjchem-1234	153	9	,	,	PUNCT
eurjchem-1234	153	10	drugs	drug	NOUN
eurjchem-1234	153	11	,	,	PUNCT
eurjchem-1234	153	12	and	and	CCONJ
eurjchem-1234	153	13	biologicals	biological	NOUN
eurjchem-1234	153	14	,	,	PUNCT
eurjchem-1234	153	15	4th	4th	ADJ
eurjchem-1234	153	16	edition	edition	NOUN
eurjchem-1234	153	17	,	,	PUNCT
eurjchem-1234	153	18	merck	merck	PROPN
eurjchem-1234	153	19	&	&	CCONJ
eurjchem-1234	153	20	co.	co.	PROPN
eurjchem-1234	153	21	,	,	PUNCT
eurjchem-1234	153	22	inc	inc	PROPN
eurjchem-1234	153	23	.	.	PROPN
eurjchem-1234	153	24	,	,	PUNCT
eurjchem-1234	153	25	whitehouse	whitehouse	NOUN
eurjchem-1234	153	26	station	station	NOUN
eurjchem-1234	153	27	,	,	PUNCT
eurjchem-1234	153	28	nj	nj	PROPN
eurjchem-1234	153	29	,	,	PUNCT
eurjchem-1234	153	30	2012	2012	NUM
eurjchem-1234	153	31	.	.	PUNCT
eurjchem-1234	154	1	[	[	X
eurjchem-1234	154	2	2	2	NUM
eurjchem-1234	154	3	]	]	PUNCT
eurjchem-1234	154	4	.	.	PUNCT
eurjchem-1234	154	5	goodarzi	goodarzi	PROPN
eurjchem-1234	154	6	,	,	PUNCT
eurjchem-1234	154	7	m.	m.	NOUN
eurjchem-1234	154	8	o.	o.	PROPN
eurjchem-1234	154	9	;	;	PUNCT
eurjchem-1234	154	10	bryer‐ash	bryer‐ash	NOUN
eurjchem-1234	154	11	,	,	PUNCT
eurjchem-1234	154	12	m.	m.	NOUN
eurjchem-1234	154	13	diabetes	diabetes	NOUN
eurjchem-1234	154	14	obes	obe	NOUN
eurjchem-1234	154	15	.	.	PUNCT
eurjchem-1234	155	1	metab	metab	NOUN
eurjchem-1234	155	2	.	.	PUNCT
eurjchem-1234	156	1	2005	2005	NUM
eurjchem-1234	156	2	,	,	PUNCT
eurjchem-1234	156	3	7(6	7(6	NUM
eurjchem-1234	156	4	)	)	PUNCT
eurjchem-1234	156	5	,	,	PUNCT
eurjchem-1234	156	6	654‐	654‐	NUM
eurjchem-1234	156	7	665	665	NUM
eurjchem-1234	156	8	.	.	PUNCT
eurjchem-1234	157	1	[	[	X
eurjchem-1234	157	2	3	3	NUM
eurjchem-1234	157	3	]	]	PUNCT
eurjchem-1234	157	4	.	.	PUNCT
eurjchem-1234	158	1	holt	holt	PROPN
eurjchem-1234	158	2	,	,	PUNCT
eurjchem-1234	158	3	r.	r.	PROPN
eurjchem-1234	158	4	i.	i.	PROPN
eurjchem-1234	158	5	g.	g.	PROPN
eurjchem-1234	158	6	;	;	PUNCT
eurjchem-1234	158	7	cockram	cockram	PROPN
eurjchem-1234	158	8	,	,	PUNCT
eurjchem-1234	158	9	c.	c.	PROPN
eurjchem-1234	158	10	;	;	PUNCT
eurjchem-1234	158	11	flyvbjerg	flyvbjerg	PROPN
eurjchem-1234	158	12	,	,	PUNCT
eurjchem-1234	158	13	a.	a.	NOUN
eurjchem-1234	158	14	;	;	PUNCT
eurjchem-1234	158	15	goldstein	goldstein	PROPN
eurjchem-1234	158	16	,	,	PUNCT
eurjchem-1234	158	17	b.	b.	PROPN
eurjchem-1234	158	18	j.	j.	PROPN
eurjchem-1234	158	19	text	text	PROPN
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eurjchem-1234	158	21	for	for	ADP
eurjchem-1234	158	22	diabetes	diabetes	NOUN
eurjchem-1234	158	23	,	,	PUNCT
eurjchem-1234	158	24	4th	4th	ADJ
eurjchem-1234	158	25	edition	edition	NOUN
eurjchem-1234	158	26	,	,	PUNCT
eurjchem-1234	158	27	john	john	PROPN
eurjchem-1234	158	28	wiley	wiley	PROPN
eurjchem-1234	158	29	&	&	CCONJ
eurjchem-1234	158	30	sons	son	NOUN
eurjchem-1234	158	31	,	,	PUNCT
eurjchem-1234	158	32	2009	2009	NUM
eurjchem-1234	158	33	.	.	PUNCT
eurjchem-1234	159	1	[	[	X
eurjchem-1234	159	2	4	4	NUM
eurjchem-1234	159	3	]	]	PUNCT
eurjchem-1234	159	4	.	.	PUNCT
eurjchem-1234	160	1	liu	liu	PROPN
eurjchem-1234	160	2	,	,	PUNCT
eurjchem-1234	160	3	a.	a.	PROPN
eurjchem-1234	160	4	;	;	PUNCT
eurjchem-1234	160	5	coleman	coleman	PROPN
eurjchem-1234	160	6	,	,	PUNCT
eurjchem-1234	160	7	s.	s.	PROPN
eurjchem-1234	160	8	p.	p.	PROPN
eurjchem-1234	160	9	j.	j.	PROPN
eurjchem-1234	160	10	chromatogr	chromatogr	PROPN
eurjchem-1234	160	11	.	.	PUNCT
eurjchem-1234	161	1	b	b	ADP
eurjchem-1234	161	2	2009	2009	NUM
eurjchem-1234	161	3	,	,	PUNCT
eurjchem-1234	161	4	877(29	877(29	NUM
eurjchem-1234	161	5	)	)	PUNCT
eurjchem-1234	161	6	,	,	PUNCT
eurjchem-1234	161	7	3695‐3700	3695‐3700	NUM
eurjchem-1234	161	8	.	.	PUNCT
eurjchem-1234	162	1	[	[	X
eurjchem-1234	162	2	5	5	NUM
eurjchem-1234	162	3	]	]	PUNCT
eurjchem-1234	162	4	.	.	PUNCT
eurjchem-1234	163	1	chen	chen	PROPN
eurjchem-1234	163	2	,	,	PUNCT
eurjchem-1234	163	3	l.	l.	PROPN
eurjchem-1234	163	4	;	;	PUNCT
eurjchem-1234	163	5	zhou	zhou	PROPN
eurjchem-1234	163	6	,	,	PUNCT
eurjchem-1234	163	7	z.	z.	PROPN
eurjchem-1234	163	8	;	;	PUNCT
eurjchem-1234	163	9	shen	shen	PROPN
eurjchem-1234	163	10	,	,	PUNCT
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eurjchem-1234	163	14	,	,	PUNCT
eurjchem-1234	163	15	a.	a.	PROPN
eurjchem-1234	163	16	j.	j.	PROPN
eurjchem-1234	163	17	chromatogr	chromatogr	PROPN
eurjchem-1234	163	18	.	.	PUNCT
eurjchem-1234	164	1	sci	sci	PROPN
eurjchem-1234	164	2	.	.	PROPN
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eurjchem-1234	164	4	,	,	PUNCT
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eurjchem-1234	165	1	[	[	X
eurjchem-1234	165	2	6	6	NUM
eurjchem-1234	165	3	]	]	PUNCT
eurjchem-1234	165	4	.	.	PUNCT
eurjchem-1234	166	1	chen	chen	PROPN
eurjchem-1234	166	2	,	,	PUNCT
eurjchem-1234	166	3	x.	x.	PROPN
eurjchem-1234	166	4	;	;	PUNCT
eurjchem-1234	166	5	gu	gu	PROPN
eurjchem-1234	166	6	,	,	PUNCT
eurjchem-1234	166	7	q.	q.	PROPN
eurjchem-1234	166	8	;	;	PUNCT
eurjchem-1234	166	9	qiu	qiu	PROPN
eurjchem-1234	166	10	,	,	PUNCT
eurjchem-1234	166	11	f.	f.	PROPN
eurjchem-1234	166	12	;	;	PUNCT
eurjchem-1234	166	13	dafa	dafa	PROPN
eurjchem-1234	166	14	,	,	PUNCT
eurjchem-1234	166	15	z.	z.	PROPN
eurjchem-1234	166	16	d.	d.	PROPN
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eurjchem-1234	167	1	b	b	PROPN
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eurjchem-1234	167	3	,	,	PUNCT
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eurjchem-1234	167	5	)	)	PUNCT
eurjchem-1234	167	6	,	,	PUNCT
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eurjchem-1234	167	8	.	.	PUNCT
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eurjchem-1234	168	3	]	]	PUNCT
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eurjchem-1234	169	1	marlice	marlice	PROPN
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eurjchem-1234	169	14	,	,	PUNCT
eurjchem-1234	169	15	o.	o.	PROPN
eurjchem-1234	169	16	w.	w.	PROPN
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eurjchem-1234	171	3	,	,	PUNCT
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eurjchem-1234	172	1	[	[	X
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eurjchem-1234	174	2	.	.	PUNCT
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eurjchem-1234	175	2	,	,	PUNCT
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eurjchem-1234	175	4	)	)	PUNCT
eurjchem-1234	175	5	,	,	PUNCT
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eurjchem-1234	176	3	]	]	PUNCT
eurjchem-1234	176	4	.	.	PUNCT
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eurjchem-1234	176	43	)	)	PUNCT
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eurjchem-1234	183	5	)	)	PUNCT
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eurjchem-1234	185	2	,	,	PUNCT
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eurjchem-1234	185	4	;	;	PUNCT
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eurjchem-1234	185	6	,	,	PUNCT
eurjchem-1234	185	7	w.	w.	PROPN
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eurjchem-1234	185	17	w.	w.	PROPN
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eurjchem-1234	188	4	)	)	PUNCT
eurjchem-1234	188	5	,	,	PUNCT
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eurjchem-1234	189	3	]	]	PUNCT
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eurjchem-1234	189	24	q.	q.	PROPN
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eurjchem-1234	190	2	.	.	PUNCT
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eurjchem-1234	191	2	,	,	PUNCT
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eurjchem-1234	191	4	)	)	PUNCT
eurjchem-1234	191	5	,	,	PUNCT
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eurjchem-1234	191	7	.	.	PUNCT
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