id	sid	tid	token	lemma	pos
eurjchem-1346	1	1	untitled	untitle	VERB
eurjchem-1346	1	2	issn	issn	PROPN
eurjchem-1346	1	3	215	215	NUM
eurjchem-1346	1	4	design	design	NOUN
eurjchem-1346	1	5	,	,	PUNCT
eurjchem-1346	1	6	new	new	ADJ
eurjchem-1346	1	7	v600	v600	PROPN
eurjchem-1346	1	8	kamelia	kamelia	NOUN
eurjchem-1346	1	9	m	m	PROPN
eurjchem-1346	1	10	usama	usama	PROPN
eurjchem-1346	1	11	ma	ma	PROPN
eurjchem-1346	1	12	1	1	PROPN
eurjchem-1346	1	13	pharmaceutica	pharmaceutica	PROPN
eurjchem-1346	1	14	2	2	NUM
eurjchem-1346	1	15	pharmaceutica	pharmaceutica	NOUN
eurjchem-1346	1	16	3	3	NUM
eurjchem-1346	1	17	research	research	NOUN
eurjchem-1346	1	18	unit	unit	NOUN
eurjchem-1346	1	19	,	,	PUNCT
eurjchem-1346	1	20	*	*	PUNCT
eurjchem-1346	1	21	corresponding	correspond	VERB
eurjchem-1346	1	22	tel	tel	PROPN
eurjchem-1346	1	23	.	.	PUNCT
eurjchem-1346	1	24	:	:	PUNCT
eurjchem-1346	2	1	+20.02.383	+20.02.383	ADP
eurjchem-1346	2	2	article	article	NOUN
eurjchem-1346	2	3	in	in	ADP
eurjchem-1346	2	4	doi	doi	PROPN
eurjchem-1346	2	5	:	:	PUNCT
eurjchem-1346	2	6	10.5155	10.5155	NUM
eurjchem-1346	2	7	/	/	SYM
eurjchem-1346	2	8	e	e	NOUN
eurjchem-1346	2	9	received	receive	VERB
eurjchem-1346	2	10	:	:	PUNCT
eurjchem-1346	2	11	22	22	NUM
eurjchem-1346	2	12	oc	oc	NOUN
eurjchem-1346	2	13	received	receive	VERB
eurjchem-1346	2	14	in	in	ADP
eurjchem-1346	2	15	rev	rev	PROPN
eurjchem-1346	2	16	accepted	accept	VERB
eurjchem-1346	2	17	:	:	PUNCT
eurjchem-1346	2	18	05	05	NUM
eurjchem-1346	2	19	de	de	X
eurjchem-1346	2	20	published	publish	VERB
eurjchem-1346	2	21	onlin	onlin	NOUN
eurjchem-1346	2	22	printed	print	VERB
eurjchem-1346	2	23	:	:	PUNCT
eurjchem-1346	2	24	31	31	NUM
eurjchem-1346	2	25	mar	mar	PROPN
eurjchem-1346	2	26	keywords	keyword	VERB
eurjchem-1346	2	27	v600ebraf	v600ebraf	ADP
eurjchem-1346	2	28	melanoma	melanoma	ADJ
eurjchem-1346	2	29	colon	colon	NOUN
eurjchem-1346	2	30	cancer	cancer	NOUN
eurjchem-1346	2	31	ovarian	ovarian	ADJ
eurjchem-1346	2	32	cancer	cancer	NOUN
eurjchem-1346	2	33	thyroid	thyroid	NOUN
eurjchem-1346	2	34	cancer	cancer	NOUN
eurjchem-1346	2	35	pyridopyrazino	pyridopyrazino	NOUN
eurjchem-1346	2	36	1	1	NUM
eurjchem-1346	2	37	.	.	X
eurjchem-1346	2	38	introduct	introduct	NOUN
eurjchem-1346	2	39	cancer	cancer	NOUN
eurjchem-1346	2	40	is	be	AUX
eurjchem-1346	2	41	properties	property	NOUN
eurjchem-1346	2	42	a	a	DET
eurjchem-1346	2	43	aggressive	aggressive	ADJ
eurjchem-1346	2	44	,	,	PUNCT
eurjchem-1346	2	45	in	in	ADV
eurjchem-1346	2	46	from	from	ADP
eurjchem-1346	2	47	inter‐	inter‐	NOUN
eurjchem-1346	2	48	a	a	PRON
eurjchem-1346	2	49	can	can	AUX
eurjchem-1346	2	50	be	be	AUX
eurjchem-1346	2	51	orig	orig	NOUN
eurjchem-1346	2	52	cytokines	cytokine	NOUN
eurjchem-1346	2	53	,	,	PUNCT
eurjchem-1346	2	54	g	g	PROPN
eurjchem-1346	2	55	generated	generate	VERB
eurjchem-1346	2	56	by	by	ADP
eurjchem-1346	2	57	g	g	PROPN
eurjchem-1346	2	58	protei	protei	ADJ
eurjchem-1346	2	59	receptor	receptor	NOUN
eurjchem-1346	2	60	tyr	tyr	PROPN
eurjchem-1346	2	61	triggers	trigger	VERB
eurjchem-1346	2	62	of	of	ADP
eurjchem-1346	2	63	in	in	ADP
eurjchem-1346	2	64	[	[	X
eurjchem-1346	2	65	2	2	NUM
eurjchem-1346	2	66	]	]	PUNCT
eurjchem-1346	2	67	.	.	PUNCT
eurjchem-1346	3	1	rapidly	rapidly	ADV
eurjchem-1346	3	2	component	component	NOUN
eurjchem-1346	3	3	carcinogenes	carcinogene	NOUN
eurjchem-1346	3	4	extracellular	extracellular	ADJ
eurjchem-1346	3	5	translocated	translocated	ADJ
eurjchem-1346	3	6	biological	biological	ADJ
eurjchem-1346	3	7	pr	pr	NOUN
eurjchem-1346	3	8	braf	braf	NOUN
eurjchem-1346	3	9	,	,	PUNCT
eurjchem-1346	3	10	and	and	CCONJ
eurjchem-1346	3	11	c	c	NOUN
eurjchem-1346	3	12	involved	involve	VERB
eurjchem-1346	3	13	in	in	ADP
eurjchem-1346	3	14	cancer	cancer	NOUN
eurjchem-1346	3	15	(	(	PUNCT
eurjchem-1346	3	16	35‐	35‐	NUM
eurjchem-1346	3	17	(	(	PUNCT
eurjchem-1346	3	18	14	14	NUM
eurjchem-1346	3	19	%	%	NOUN
eurjchem-1346	3	20	)	)	PUNCT
eurjchem-1346	3	21	,	,	PUNCT
eurjchem-1346	3	22	and	and	CCONJ
eurjchem-1346	3	23	o	o	X
eurjchem-1346	3	24	53‐2249	53‐2249	NUM
eurjchem-1346	3	25	(	(	PUNCT
eurjchem-1346	3	26	print	print	NOUN
eurjchem-1346	3	27	)	)	PUNCT
eurjchem-1346	3	28	synthesis	synthesis	NOUN
eurjchem-1346	3	29	0ebraf	0ebraf	NUM
eurjchem-1346	3	30	in	in	ADP
eurjchem-1346	3	31	mahmoud	mahmoud	PROPN
eurjchem-1346	3	32	am	be	AUX
eurjchem-1346	3	33	agdi	agdi	PROPN
eurjchem-1346	3	34	ammar	ammar	PROPN
eurjchem-1346	3	35	al	al	PROPN
eurjchem-1346	3	36	chemistry	chemistry	PROPN
eurjchem-1346	3	37	depar	depar	NOUN
eurjchem-1346	3	38	al	al	PROPN
eurjchem-1346	3	39	chemistry	chemistry	PROPN
eurjchem-1346	3	40	depar	depar	PROPN
eurjchem-1346	3	41	saco	saco	PROPN
eurjchem-1346	3	42	pharma	pharma	PROPN
eurjchem-1346	3	43	com	com	NOUN
eurjchem-1346	3	44	g	g	PROPN
eurjchem-1346	3	45	author	author	NOUN
eurjchem-1346	3	46	at	at	ADP
eurjchem-1346	3	47	:	:	PUNCT
eurjchem-1346	3	48	pharm	pharm	NOUN
eurjchem-1346	3	49	376751	376751	NUM
eurjchem-1346	3	50	.	.	PUNCT
eurjchem-1346	4	1	fax	fax	NOUN
eurjchem-1346	4	2	:	:	PUNCT
eurjchem-1346	4	3	+20.02	+20.02	ADJ
eurjchem-1346	4	4	formation	formation	NOUN
eurjchem-1346	4	5	eurjchem.7.1.19‐29	eurjchem.7.1.19‐29	ADJ
eurjchem-1346	4	6	ctober	ctober	NOUN
eurjchem-1346	4	7	2015	2015	NUM
eurjchem-1346	4	8	vised	vise	VERB
eurjchem-1346	4	9	form	form	NOUN
eurjchem-1346	4	10	:	:	PUNCT
eurjchem-1346	4	11	02	02	NUM
eurjchem-1346	4	12	dece	dece	PROPN
eurjchem-1346	4	13	ecember	ecember	PROPN
eurjchem-1346	4	14	2015	2015	NUM
eurjchem-1346	4	15	ne	ne	PROPN
eurjchem-1346	4	16	:	:	PUNCT
eurjchem-1346	4	17	31	31	NUM
eurjchem-1346	4	18	march	march	PROPN
eurjchem-1346	4	19	2016	2016	NUM
eurjchem-1346	4	20	rch	rch	NOUN
eurjchem-1346	4	21	2016	2016	NUM
eurjchem-1346	4	22	s	s	NOUN
eurjchem-1346	4	23	r	r	NOUN
eurjchem-1346	4	24	one	one	NUM
eurjchem-1346	4	25	tion	tion	NOUN
eurjchem-1346	4	26	s	s	VERB
eurjchem-1346	4	27	a	a	DET
eurjchem-1346	4	28	group	group	NOUN
eurjchem-1346	4	29	of	of	ADP
eurjchem-1346	4	30	dis	dis	PROPN
eurjchem-1346	4	31	are	be	AUX
eurjchem-1346	4	32	involved	involve	VERB
eurjchem-1346	4	33	r	r	NOUN
eurjchem-1346	4	34	nvasive	nvasive	NOUN
eurjchem-1346	4	35	,	,	PUNCT
eurjchem-1346	4	36	and	and	CCONJ
eurjchem-1346	4	37	po	po	NOUN
eurjchem-1346	4	38	and	and	CCONJ
eurjchem-1346	4	39	intra‐cellula	intra‐cellula	NOUN
eurjchem-1346	4	40	ginated	ginate	VERB
eurjchem-1346	4	41	from	from	ADP
eurjchem-1346	4	42	growth	growth	NOUN
eurjchem-1346	4	43	factor	factor	NOUN
eurjchem-1346	4	44	y	y	PROPN
eurjchem-1346	4	45	oncogenes	oncogene	VERB
eurjchem-1346	5	1	[	[	X
eurjchem-1346	5	2	1	1	NUM
eurjchem-1346	5	3	]	]	X
eurjchem-1346	5	4	ins	in	NOUN
eurjchem-1346	5	5	,	,	PUNCT
eurjchem-1346	5	6	receptors	receptor	NOUN
eurjchem-1346	5	7	rosine	rosine	NOUN
eurjchem-1346	5	8	kinases	kinase	NOUN
eurjchem-1346	5	9	ntracellular	ntracellular	PROPN
eurjchem-1346	5	10	sign	sign	VERB
eurjchem-1346	5	11	y	y	PROPN
eurjchem-1346	5	12	growing	grow	VERB
eurjchem-1346	5	13	fibr	fibr	PROPN
eurjchem-1346	5	14	of	of	ADP
eurjchem-1346	5	15	rtk	rtk	PROPN
eurjchem-1346	5	16	that	that	SCONJ
eurjchem-1346	5	17	sis	sis	PROPN
eurjchem-1346	5	18	.	.	PUNCT
eurjchem-1346	5	19	phosphoryl	phosphoryl	PROPN
eurjchem-1346	6	1	r	r	PROPN
eurjchem-1346	6	2	signal‐regul	signal‐regul	PROPN
eurjchem-1346	6	3	d	d	X
eurjchem-1346	6	4	to	to	ADP
eurjchem-1346	6	5	nucleus	nucleus	PROPN
eurjchem-1346	6	6	to	to	PART
eurjchem-1346	6	7	rocess	rocess	VERB
eurjchem-1346	6	8	[	[	X
eurjchem-1346	6	9	3	3	NUM
eurjchem-1346	6	10	]	]	PUNCT
eurjchem-1346	6	11	.	.	PUNCT
eurjchem-1346	7	1	thre	thre	NOUN
eurjchem-1346	7	2	craf	craf	PROPN
eurjchem-1346	7	3	were	be	AUX
eurjchem-1346	7	4	kn	kn	PROPN
eurjchem-1346	7	5	many	many	ADJ
eurjchem-1346	7	6	cancer	cancer	NOUN
eurjchem-1346	7	7	c	c	NOUN
eurjchem-1346	7	8	70	70	NUM
eurjchem-1346	7	9	%	%	NOUN
eurjchem-1346	7	10	)	)	PUNCT
eurjchem-1346	7	11	,	,	PUNCT
eurjchem-1346	7	12	colorec	colorec	X
eurjchem-1346	7	13	ovarian	ovarian	ADJ
eurjchem-1346	7	14	cancer	cancer	NOUN
eurjchem-1346	7	15	(	(	PUNCT
eurjchem-1346	7	16	/	/	SYM
eurjchem-1346	7	17	issn	issn	PROPN
eurjchem-1346	7	18	2153‐225	2153‐225	NUM
eurjchem-1346	7	19	ht	ht	NOUN
eurjchem-1346	7	20	europ	europ	PROPN
eurjchem-1346	7	21	s	s	PROPN
eurjchem-1346	7	22	,	,	PUNCT
eurjchem-1346	7	23	antican	antican	PROPN
eurjchem-1346	7	24	nhibitors	nhibitor	NOUN
eurjchem-1346	7	25	min	min	NOUN
eurjchem-1346	7	26	1	1	NUM
eurjchem-1346	7	27	,	,	PUNCT
eurjchem-1346	7	28	ossam	ossam	ADJ
eurjchem-1346	7	29	r	r	NOUN
eurjchem-1346	7	30	2	2	NUM
eurjchem-1346	7	31	,	,	PUNCT
eurjchem-1346	7	32	*	*	PUNCT
eurjchem-1346	7	33	and	and	CCONJ
eurjchem-1346	7	34	moh	moh	PROPN
eurjchem-1346	7	35	rtment	rtment	NOUN
eurjchem-1346	7	36	,	,	PUNCT
eurjchem-1346	7	37	faculty	faculty	NOUN
eurjchem-1346	7	38	of	of	ADP
eurjchem-1346	7	39	p	p	PROPN
eurjchem-1346	7	40	rtment	rtment	NOUN
eurjchem-1346	7	41	,	,	PUNCT
eurjchem-1346	7	42	faculty	faculty	NOUN
eurjchem-1346	7	43	of	of	ADP
eurjchem-1346	7	44	p	p	PROPN
eurjchem-1346	7	45	mpany	mpany	NOUN
eurjchem-1346	7	46	,	,	PUNCT
eurjchem-1346	7	47	6th	6th	NOUN
eurjchem-1346	7	48	of	of	ADP
eurjchem-1346	7	49	octob	octob	ADJ
eurjchem-1346	7	50	aceutical	aceutical	ADJ
eurjchem-1346	7	51	chemistry	chemistry	NOUN
eurjchem-1346	7	52	2.38334379	2.38334379	NUM
eurjchem-1346	7	53	.	.	PUNCT
eurjchem-1346	8	1	e‐mai	e‐mai	PROPN
eurjchem-1346	9	1	9.1346	9.1346	NUM
eurjchem-1346	9	2	ember	ember	NOUN
eurjchem-1346	9	3	2015	2015	NUM
eurjchem-1346	9	4	seases	sease	NOUN
eurjchem-1346	9	5	in	in	ADP
eurjchem-1346	9	6	which	which	PRON
eurjchem-1346	9	7	related	relate	VERB
eurjchem-1346	9	8	to	to	ADP
eurjchem-1346	9	9	the	the	DET
eurjchem-1346	9	10	ossibility	ossibility	NOUN
eurjchem-1346	9	11	of	of	ADP
eurjchem-1346	9	12	met	meet	VERB
eurjchem-1346	9	13	ar	ar	PROPN
eurjchem-1346	9	14	communicat	communicat	NOUN
eurjchem-1346	9	15	false	false	ADJ
eurjchem-1346	9	16	messen	messen	NOUN
eurjchem-1346	9	17	rs	rs	NOUN
eurjchem-1346	9	18	or	or	CCONJ
eurjchem-1346	9	19	false	false	ADJ
eurjchem-1346	9	20	s	s	X
eurjchem-1346	9	21	]	]	PUNCT
eurjchem-1346	9	22	.	.	PUNCT
eurjchem-1346	10	1	tyrosine	tyrosine	PROPN
eurjchem-1346	10	2	kinas	kinas	PROPN
eurjchem-1346	10	3	(	(	PUNCT
eurjchem-1346	10	4	nrtk	nrtk	PROPN
eurjchem-1346	10	5	)	)	PUNCT
eurjchem-1346	10	6	are	be	AUX
eurjchem-1346	10	7	co	co	VERB
eurjchem-1346	10	8	nal	nal	ADJ
eurjchem-1346	10	9	transduction	transduction	NOUN
eurjchem-1346	10	10	rosarcoma	rosarcoma	NOUN
eurjchem-1346	10	11	(	(	PUNCT
eurjchem-1346	10	12	ra	ra	PROPN
eurjchem-1346	10	13	included	include	VERB
eurjchem-1346	10	14	the	the	DET
eurjchem-1346	10	15	lation	lation	NOUN
eurjchem-1346	10	16	of	of	ADP
eurjchem-1346	10	17	raf	raf	PROPN
eurjchem-1346	10	18	re	re	AUX
eurjchem-1346	10	19	ated	ate	VERB
eurjchem-1346	10	20	kinase	kinase	PROPN
eurjchem-1346	10	21	trigger	trigger	NOUN
eurjchem-1346	10	22	cell	cell	NOUN
eurjchem-1346	10	23	pro	pro	X
eurjchem-1346	10	24	ee	ee	PROPN
eurjchem-1346	10	25	isoforms	isoform	NOUN
eurjchem-1346	10	26	of	of	ADP
eurjchem-1346	10	27	own	own	ADJ
eurjchem-1346	10	28	[	[	X
eurjchem-1346	10	29	4	4	NUM
eurjchem-1346	10	30	]	]	PUNCT
eurjchem-1346	10	31	.	.	PUNCT
eurjchem-1346	11	1	braf	braf	NOUN
eurjchem-1346	11	2	cells	cell	NOUN
eurjchem-1346	11	3	as	as	ADP
eurjchem-1346	11	4	melan	melan	NOUN
eurjchem-1346	11	5	tal	tal	PROPN
eurjchem-1346	11	6	cancer	cancer	NOUN
eurjchem-1346	11	7	(	(	PUNCT
eurjchem-1346	11	8	5‐	5‐	NUM
eurjchem-1346	11	9	(	(	PUNCT
eurjchem-1346	11	10	30	30	NUM
eurjchem-1346	11	11	%	%	NOUN
eurjchem-1346	11	12	)	)	PUNCT
eurjchem-1346	12	1	[	[	X
eurjchem-1346	12	2	5‐11	5‐11	NUM
eurjchem-1346	12	3	]	]	X
eurjchem-1346	12	4	.	.	PUNCT
eurjchem-1346	13	1	european	european	PROPN
eurjchem-1346	13	2	journ	journ	PROPN
eurjchem-1346	13	3	europ	europ	PROPN
eurjchem-1346	13	4	57	57	NUM
eurjchem-1346	13	5	(	(	PUNCT
eurjchem-1346	13	6	online	online	ADJ
eurjchem-1346	13	7	)	)	PUNCT
eurjchem-1346	13	8			NOUN
eurjchem-1346	13	9	20	20	NUM
eurjchem-1346	13	10	ttp://dx.doi.org	ttp://dx.doi.org	PROPN
eurjchem-1346	13	11	pean	pean	PROPN
eurjchem-1346	13	12	jo	jo	PROPN
eurjchem-1346	13	13	journal	journal	PROPN
eurjchem-1346	13	14	web	web	PROPN
eurjchem-1346	13	15	cer	cer	PROPN
eurjchem-1346	13	16	evalu	evalu	NOUN
eurjchem-1346	13	17	derived	derive	VERB
eurjchem-1346	13	18	fr	fr	PROPN
eurjchem-1346	13	19	ma	ma	PROPN
eurjchem-1346	13	20	metwally	metwally	ADV
eurjchem-1346	13	21	hamed	ham	VERB
eurjchem-1346	13	22	most	most	ADJ
eurjchem-1346	13	23	pharmacy	pharmacy	NOUN
eurjchem-1346	13	24	,	,	PUNCT
eurjchem-1346	13	25	cairo	cairo	PROPN
eurjchem-1346	13	26	un	un	PROPN
eurjchem-1346	13	27	pharmacy	pharmacy	PROPN
eurjchem-1346	13	28	,	,	PUNCT
eurjchem-1346	13	29	ahram	ahram	PROPN
eurjchem-1346	13	30	c	c	PROPN
eurjchem-1346	13	31	er	er	INTJ
eurjchem-1346	13	32	city	city	PROPN
eurjchem-1346	13	33	,	,	PUNCT
eurjchem-1346	13	34	egypt	egypt	PROPN
eurjchem-1346	13	35	ry	ry	PROPN
eurjchem-1346	13	36	department	department	PROPN
eurjchem-1346	13	37	,	,	PUNCT
eurjchem-1346	13	38	fac	fac	PROPN
eurjchem-1346	13	39	l	l	NOUN
eurjchem-1346	13	40	address	address	NOUN
eurjchem-1346	13	41	:	:	PUNCT
eurjchem-1346	13	42	usama_a	usama_a	X
eurjchem-1346	13	43	abstract	abstract	ADJ
eurjchem-1346	13	44	design	design	NOUN
eurjchem-1346	13	45	and	and	CCONJ
eurjchem-1346	13	46	sy	sy	ADV
eurjchem-1346	13	47	described	describe	VERB
eurjchem-1346	13	48	.	.	PUNCT
eurjchem-1346	14	1	th	th	X
eurjchem-1346	14	2	(	(	PUNCT
eurjchem-1346	14	3	loximvi	loximvi	PROPN
eurjchem-1346	14	4	)	)	PUNCT
eurjchem-1346	14	5	,	,	PUNCT
eurjchem-1346	14	6	ov	ov	INTJ
eurjchem-1346	14	7	and	and	CCONJ
eurjchem-1346	14	8	colon	colon	NOUN
eurjchem-1346	14	9	ce	ce	PROPN
eurjchem-1346	14	10	compounds	compound	VERB
eurjchem-1346	14	11	w	w	NOUN
eurjchem-1346	14	12	activity	activity	NOUN
eurjchem-1346	14	13	again	again	ADV
eurjchem-1346	14	14	v600ebraf	v600ebraf	NOUN
eurjchem-1346	14	15	wa	wa	PROPN
eurjchem-1346	14	16	tested	test	VERB
eurjchem-1346	14	17	compo	compo	PROPN
eurjchem-1346	14	18	kinase	kinase	PROPN
eurjchem-1346	14	19	inhibit	inhibit	PROPN
eurjchem-1346	14	20	6b	6b	PROPN
eurjchem-1346	14	21	were	be	AUX
eurjchem-1346	14	22	poten	poten	ADV
eurjchem-1346	14	23	melanoma	melanoma	ADJ
eurjchem-1346	14	24	,	,	PUNCT
eurjchem-1346	14	25	ov	ov	VERB
eurjchem-1346	14	26	with	with	ADP
eurjchem-1346	14	27	different	different	ADJ
eurjchem-1346	14	28	potent	potent	ADJ
eurjchem-1346	14	29	v600eb	v600eb	ADJ
eurjchem-1346	14	30	cancer	cancer	NOUN
eurjchem-1346	14	31	types	type	NOUN
eurjchem-1346	14	32	s	s	AUX
eurjchem-1346	14	33	cite	cite	VERB
eurjchem-1346	14	34	this	this	PRON
eurjchem-1346	14	35	:	:	PUNCT
eurjchem-1346	14	36	eur	eur	ADJ
eurjchem-1346	14	37	.	.	PUNCT
eurjchem-1346	15	1	h	h	NOUN
eurjchem-1346	15	2	,	,	PUNCT
eurjchem-1346	15	3	three	three	NUM
eurjchem-1346	15	4	characte	characte	NOUN
eurjchem-1346	15	5	cancer	cancer	NOUN
eurjchem-1346	15	6	cells	cell	NOUN
eurjchem-1346	15	7	:	:	PUNCT
eurjchem-1346	15	8	tastasis	tastasis	NOUN
eurjchem-1346	16	1	[	[	X
eurjchem-1346	16	2	1	1	NUM
eurjchem-1346	16	3	]	]	PUNCT
eurjchem-1346	16	4	.	.	PUNCT
eurjchem-1346	17	1	it	it	PRON
eurjchem-1346	17	2	r	r	NOUN
eurjchem-1346	17	3	tion	tion	NOUN
eurjchem-1346	17	4	disorders	disorder	NOUN
eurjchem-1346	17	5	,	,	PUNCT
eurjchem-1346	17	6	w	w	NOUN
eurjchem-1346	17	7	gers	ger	NOUN
eurjchem-1346	17	8	by	by	ADP
eurjchem-1346	17	9	horm	horm	NOUN
eurjchem-1346	17	10	signal	signal	PROPN
eurjchem-1346	17	11	transdu	transdu	NOUN
eurjchem-1346	17	12	ses	se	NOUN
eurjchem-1346	17	13	(	(	PUNCT
eurjchem-1346	17	14	rtk	rtk	NOUN
eurjchem-1346	17	15	)	)	PUNCT
eurjchem-1346	17	16	and	and	CCONJ
eurjchem-1346	17	17	onsidered	onsidere	VERB
eurjchem-1346	17	18	impo	impo	PROPN
eurjchem-1346	17	19	n	n	PROPN
eurjchem-1346	17	20	of	of	ADP
eurjchem-1346	17	21	cell	cell	NOUN
eurjchem-1346	17	22	prolifer	prolifer	NOUN
eurjchem-1346	17	23	af	af	PROPN
eurjchem-1346	17	24	)	)	PUNCT
eurjchem-1346	17	25	is	be	AUX
eurjchem-1346	17	26	conside	conside	VERB
eurjchem-1346	17	27	key	key	ADJ
eurjchem-1346	17	28	mediato	mediato	NOUN
eurjchem-1346	17	29	esults	esult	NOUN
eurjchem-1346	17	30	in	in	ADP
eurjchem-1346	17	31	activat	activat	PROPN
eurjchem-1346	17	32	(	(	PUNCT
eurjchem-1346	17	33	erk	erk	NOUN
eurjchem-1346	17	34	)	)	PUNCT
eurjchem-1346	17	35	that	that	SCONJ
eurjchem-1346	17	36	oliferation	oliferation	NOUN
eurjchem-1346	17	37	and	and	CCONJ
eurjchem-1346	17	38	raf	raf	PROPN
eurjchem-1346	17	39	kinases	kinase	NOUN
eurjchem-1346	17	40	;	;	PUNCT
eurjchem-1346	17	41	a	a	DET
eurjchem-1346	17	42	f	f	PROPN
eurjchem-1346	17	43	mutation	mutation	NOUN
eurjchem-1346	17	44	is	be	AUX
eurjchem-1346	17	45	h	h	PROPN
eurjchem-1346	17	46	oma	oma	PROPN
eurjchem-1346	17	47	(	(	PUNCT
eurjchem-1346	17	48	66	66	NUM
eurjchem-1346	17	49	%	%	NOUN
eurjchem-1346	17	50	)	)	PUNCT
eurjchem-1346	17	51	,	,	PUNCT
eurjchem-1346	18	1	th	th	X
eurjchem-1346	18	2	‐20	‐20	NOUN
eurjchem-1346	18	3	%	%	NOUN
eurjchem-1346	18	4	)	)	PUNCT
eurjchem-1346	18	5	,	,	PUNCT
eurjchem-1346	18	6	liver	liver	NOUN
eurjchem-1346	18	7	c	c	PROPN
eurjchem-1346	18	8	al	al	PROPN
eurjchem-1346	18	9	of	of	ADP
eurjchem-1346	18	10	chemistry	chemistry	PROPN
eurjchem-1346	18	11	7	7	NUM
eurjchem-1346	18	12	pean	pean	ADJ
eurjchem-1346	18	13	journal	journal	NOUN
eurjchem-1346	18	14	of	of	ADP
eurjchem-1346	18	15	c	c	PROPN
eurjchem-1346	18	16	016	016	NUM
eurjchem-1346	18	17	atlanta	atlanta	PROPN
eurjchem-1346	18	18	pub	pub	NOUN
eurjchem-1346	18	19	/10.5155	/10.5155	PROPN
eurjchem-1346	18	20	/	/	SYM
eurjchem-1346	18	21	eurjch	eurjch	PROPN
eurjchem-1346	18	22	ournal	ournal	ADJ
eurjchem-1346	18	23	bpage	bpage	NOUN
eurjchem-1346	18	24	:	:	PUNCT
eurjchem-1346	18	25	www	www	PROPN
eurjchem-1346	18	26	.	.	PROPN
eurjchem-1346	18	27	ation	ation	PROPN
eurjchem-1346	18	28	and	and	CCONJ
eurjchem-1346	18	29	rom	rom	NOUN
eurjchem-1346	18	30	pyrid	pyrid	VERB
eurjchem-1346	18	31	y	y	PROPN
eurjchem-1346	18	32	el‐badry	el‐badry	ADJ
eurjchem-1346	18	33	2	2	NUM
eurjchem-1346	18	34	,	,	PUNCT
eurjchem-1346	18	35	tafa	tafa	PROPN
eurjchem-1346	18	36	abdalla	abdalla	PROPN
eurjchem-1346	18	37	niversity	niversity	PROPN
eurjchem-1346	18	38	,	,	PUNCT
eurjchem-1346	18	39	cairo	cairo	PROPN
eurjchem-1346	18	40	,	,	PUNCT
eurjchem-1346	18	41	115	115	NUM
eurjchem-1346	18	42	canadian	canadian	PROPN
eurjchem-1346	18	43	university	university	PROPN
eurjchem-1346	18	44	culty	culty	NOUN
eurjchem-1346	18	45	of	of	ADP
eurjchem-1346	18	46	pharmacy	pharmacy	NOUN
eurjchem-1346	18	47	,	,	PUNCT
eurjchem-1346	18	48	a	a	DET
eurjchem-1346	18	49	acu@hotmail.com	acu@hotmail.com	PROPN
eurjchem-1346	18	50	(	(	PUNCT
eurjchem-1346	18	51	ynthesis	ynthesis	NOUN
eurjchem-1346	18	52	of	of	ADP
eurjchem-1346	18	53	some	some	PRON
eurjchem-1346	18	54	he	he	PRON
eurjchem-1346	18	55	cytotoxic	cytotoxic	ADJ
eurjchem-1346	18	56	activ	activ	PROPN
eurjchem-1346	18	57	varian	varian	PROPN
eurjchem-1346	18	58	cell	cell	PROPN
eurjchem-1346	18	59	line	line	PROPN
eurjchem-1346	18	60	ell	ell	INTJ
eurjchem-1346	18	61	lines	line	NOUN
eurjchem-1346	18	62	(	(	PUNCT
eurjchem-1346	18	63	ht29	ht29	PROPN
eurjchem-1346	18	64	were	be	AUX
eurjchem-1346	18	65	active	active	ADJ
eurjchem-1346	18	66	and	and	CCONJ
eurjchem-1346	18	67	st	st	PROPN
eurjchem-1346	18	68	all	all	DET
eurjchem-1346	18	69	tested	test	VERB
eurjchem-1346	18	70	cell	cell	NOUN
eurjchem-1346	18	71	s	s	PRON
eurjchem-1346	18	72	performed	perform	VERB
eurjchem-1346	18	73	for	for	ADP
eurjchem-1346	18	74	ounds	ound	NOUN
eurjchem-1346	18	75	was	be	AUX
eurjchem-1346	18	76	estab	estab	NOUN
eurjchem-1346	18	77	tion	tion	NOUN
eurjchem-1346	18	78	assay	assay	VERB
eurjchem-1346	18	79	and	and	CCONJ
eurjchem-1346	18	80	m	m	VERB
eurjchem-1346	18	81	nt	not	PART
eurjchem-1346	18	82	inhibitors	inhibitor	NOUN
eurjchem-1346	18	83	for	for	ADP
eurjchem-1346	18	84	varian	varian	NOUN
eurjchem-1346	18	85	and	and	CCONJ
eurjchem-1346	18	86	thyro	thyro	NOUN
eurjchem-1346	18	87	t	t	PROPN
eurjchem-1346	18	88	substituents	substituent	NOUN
eurjchem-1346	18	89	at	at	ADP
eurjchem-1346	18	90	raf	raf	NOUN
eurjchem-1346	18	91	inhibitors	inhibitor	NOUN
eurjchem-1346	18	92	such	such	ADJ
eurjchem-1346	18	93	as	as	ADP
eurjchem-1346	18	94	melanom	melanom	NOUN
eurjchem-1346	18	95	.	.	PUNCT
eurjchem-1346	19	1	j.	j.	PROPN
eurjchem-1346	19	2	chem	chem	PROPN
eurjchem-1346	19	3	.	.	PUNCT
eurjchem-1346	20	1	2016	2016	NUM
eurjchem-1346	20	2	,	,	PUNCT
eurjchem-1346	20	3	eristic	eristic	ADJ
eurjchem-1346	20	4	being	being	NOUN
eurjchem-1346	20	5	results	result	NOUN
eurjchem-1346	20	6	which	which	PRON
eurjchem-1346	20	7	mones	mone	NOUN
eurjchem-1346	20	8	,	,	PUNCT
eurjchem-1346	20	9	uction	uction	NOUN
eurjchem-1346	20	10	d	d	PROPN
eurjchem-1346	20	11	non‐	non‐	PROPN
eurjchem-1346	20	12	ortant	ortant	ADJ
eurjchem-1346	20	13	ration	ration	NOUN
eurjchem-1346	20	14	red	red	VERB
eurjchem-1346	20	15	a	a	DET
eurjchem-1346	20	16	ors	or	NOUN
eurjchem-1346	20	17	of	of	ADP
eurjchem-1346	20	18	tion	tion	NOUN
eurjchem-1346	20	19	of	of	ADP
eurjchem-1346	20	20	was	be	AUX
eurjchem-1346	20	21	other	other	ADJ
eurjchem-1346	20	22	araf	araf	NOUN
eurjchem-1346	20	23	,	,	PUNCT
eurjchem-1346	20	24	highly	highly	ADV
eurjchem-1346	20	25	hyroid	hyroid	PROPN
eurjchem-1346	20	26	cancer	cancer	NOUN
eurjchem-1346	20	27	mut	mut	PROPN
eurjchem-1346	20	28	sub	sub	PROPN
eurjchem-1346	20	29	loop	loop	PROPN
eurjchem-1346	20	30	dur	dur	PROPN
eurjchem-1346	20	31	to	to	ADP
eurjchem-1346	20	32	t	t	PROPN
eurjchem-1346	20	33	ren	ren	PROPN
eurjchem-1346	20	34	gro	gro	PROPN
eurjchem-1346	20	35	crit	crit	PROPN
eurjchem-1346	20	36	cate	cate	PROPN
eurjchem-1346	20	37	whi	whi	PROPN
eurjchem-1346	20	38	con	con	PROPN
eurjchem-1346	20	39	targ	targ	PROPN
eurjchem-1346	20	40	targ	targ	PROPN
eurjchem-1346	20	41	only	only	ADV
eurjchem-1346	20	42	pha	pha	PROPN
eurjchem-1346	20	43	sb5	sb5	VERB
eurjchem-1346	20	44	in	in	ADP
eurjchem-1346	20	45	v	v	NUM
eurjchem-1346	20	46	pro	pro	X
eurjchem-1346	20	47	7	7	NUM
eurjchem-1346	20	48	(	(	PUNCT
eurjchem-1346	20	49	1	1	NUM
eurjchem-1346	20	50	)	)	PUNCT
eurjchem-1346	20	51	(	(	PUNCT
eurjchem-1346	20	52	2016	2016	NUM
eurjchem-1346	20	53	)	)	PUNCT
eurjchem-1346	20	54	19‐	19‐	NUM
eurjchem-1346	20	55	chemistry	chemistry	NOUN
eurjchem-1346	20	56	lishing	lishe	VERB
eurjchem-1346	20	57	house	house	NOUN
eurjchem-1346	20	58	ll	ll	AUX
eurjchem-1346	20	59	hem.7.1.19‐29.1	hem.7.1.19‐29.1	PROPN
eurjchem-1346	20	60	of	of	ADP
eurjchem-1346	20	61	che	che	PROPN
eurjchem-1346	20	62	.eurjchem.co	.eurjchem.co	PROPN
eurjchem-1346	21	1	d	d	X
eurjchem-1346	21	2	molecul	molecul	PROPN
eurjchem-1346	21	3	dopyrazin	dopyrazin	PROPN
eurjchem-1346	21	4	,	,	PUNCT
eurjchem-1346	21	5	doaa	doaa	AUX
eurjchem-1346	21	6	ezzat	ezzat	VERB
eurjchem-1346	21	7	3	3	NUM
eurjchem-1346	21	8	562	562	NUM
eurjchem-1346	21	9	,	,	PUNCT
eurjchem-1346	21	10	egypt	egypt	PROPN
eurjchem-1346	21	11	ty	ty	PRON
eurjchem-1346	21	12	,	,	PUNCT
eurjchem-1346	21	13	giza	giza	PROPN
eurjchem-1346	21	14	,	,	PUNCT
eurjchem-1346	21	15	12566	12566	NUM
eurjchem-1346	21	16	,	,	PUNCT
eurjchem-1346	21	17	egy	egy	PROPN
eurjchem-1346	21	18	ahram	ahram	PROPN
eurjchem-1346	21	19	canadian	canadian	PROPN
eurjchem-1346	21	20	u	u	PROPN
eurjchem-1346	21	21	(	(	PUNCT
eurjchem-1346	21	22	u.m	u.m	PROPN
eurjchem-1346	21	23	.	.	PROPN
eurjchem-1346	21	24	ammar	ammar	PROPN
eurjchem-1346	21	25	)	)	PUNCT
eurjchem-1346	21	26	.	.	PUNCT
eurjchem-1346	22	1	e	e	X
eurjchem-1346	22	2	new	new	ADJ
eurjchem-1346	22	3	pyridopyra	pyridopyra	ADJ
eurjchem-1346	22	4	vities	vitie	NOUN
eurjchem-1346	22	5	of	of	ADP
eurjchem-1346	22	6	the	the	DET
eurjchem-1346	22	7	syn	syn	NOUN
eurjchem-1346	22	8	(	(	PUNCT
eurjchem-1346	22	9	ovcar3	ovcar3	PROPN
eurjchem-1346	22	10	)	)	PUNCT
eurjchem-1346	22	11	,	,	PUNCT
eurjchem-1346	22	12	thyr	thyr	ADJ
eurjchem-1346	22	13	and	and	CCONJ
eurjchem-1346	22	14	hct116	hct116	PROPN
eurjchem-1346	22	15	)	)	PUNCT
eurjchem-1346	22	16	compound	compound	NOUN
eurjchem-1346	22	17	3d	3d	NOUN
eurjchem-1346	22	18	w	w	NOUN
eurjchem-1346	22	19	lines	line	NOUN
eurjchem-1346	22	20	.	.	PUNCT
eurjchem-1346	23	1	in	in	ADP
eurjchem-1346	23	2	additio	additio	ADP
eurjchem-1346	23	3	r	r	PRON
eurjchem-1346	23	4	all	all	PRON
eurjchem-1346	23	5	synthesized	synthesize	VERB
eurjchem-1346	23	6	blished	blishe	VERB
eurjchem-1346	23	7	with	with	ADP
eurjchem-1346	23	8	act	act	NOUN
eurjchem-1346	23	9	molecular	molecular	ADJ
eurjchem-1346	23	10	dockin	dockin	ADJ
eurjchem-1346	23	11	r	r	PROPN
eurjchem-1346	23	12	v600ebraf	v600ebraf	PROPN
eurjchem-1346	23	13	kinas	kinas	PROPN
eurjchem-1346	23	14	oid	oid	PROPN
eurjchem-1346	23	15	cancer	cancer	NOUN
eurjchem-1346	23	16	.	.	PUNCT
eurjchem-1346	24	1	the	the	DET
eurjchem-1346	24	2	n	n	PROPN
eurjchem-1346	24	3	t	t	NOUN
eurjchem-1346	24	4	c‐3	c‐3	NOUN
eurjchem-1346	24	5	or	or	CCONJ
eurjchem-1346	24	6	fused	fuse	VERB
eurjchem-1346	24	7	w	w	NOUN
eurjchem-1346	24	8	and	and	CCONJ
eurjchem-1346	24	9	exhibited	exhibit	VERB
eurjchem-1346	24	10	ma	ma	PROPN
eurjchem-1346	24	11	,	,	PUNCT
eurjchem-1346	24	12	ovarian	ovarian	ADJ
eurjchem-1346	24	13	,	,	PUNCT
eurjchem-1346	24	14	thyr	thyr	ADJ
eurjchem-1346	24	15	7(1	7(1	NUM
eurjchem-1346	24	16	)	)	PUNCT
eurjchem-1346	24	17	,	,	PUNCT
eurjchem-1346	24	18	19‐29	19‐29	NUM
eurjchem-1346	24	19	the	the	DET
eurjchem-1346	24	20	most	most	ADV
eurjchem-1346	24	21	com	com	NOUN
eurjchem-1346	24	22	tations	tation	NOUN
eurjchem-1346	24	23	is	be	AUX
eurjchem-1346	24	24	v600e	v600e	VERB
eurjchem-1346	24	25	bstitution	bstitution	NOUN
eurjchem-1346	24	26	(	(	PUNCT
eurjchem-1346	24	27	val	val	NOUN
eurjchem-1346	24	28	p	p	X
eurjchem-1346	24	29	)	)	PUNCT
eurjchem-1346	24	30	which	which	PRON
eurjchem-1346	24	31	is	be	AUX
eurjchem-1346	24	32	ad	ad	NOUN
eurjchem-1346	24	33	ring	ring	NOUN
eurjchem-1346	24	34	braf	braf	NOUN
eurjchem-1346	24	35	activ	activ	NOUN
eurjchem-1346	24	36	the	the	DET
eurjchem-1346	24	37	phosphory	phosphory	ADJ
eurjchem-1346	24	38	dering	dering	PROPN
eurjchem-1346	25	1	v600ebra	v600ebra	PUNCT
eurjchem-1346	25	2	wth	wth	NOUN
eurjchem-1346	26	1	[	[	X
eurjchem-1346	26	2	5,6,12,13	5,6,12,13	NUM
eurjchem-1346	26	3	tical	tical	ADJ
eurjchem-1346	26	4	therapeutic	therapeutic	ADJ
eurjchem-1346	26	5	braf	braf	NOUN
eurjchem-1346	26	6	kinase	kinase	NOUN
eurjchem-1346	26	7	egories	egorie	NOUN
eurjchem-1346	26	8	;	;	PUNCT
eurjchem-1346	26	9	type	type	NOUN
eurjchem-1346	26	10	i	i	PRON
eurjchem-1346	26	11	ich	ich	NOUN
eurjchem-1346	26	12	bind	bind	VERB
eurjchem-1346	26	13	to	to	ADP
eurjchem-1346	26	14	nformation	nformation	NOUN
eurjchem-1346	26	15	.	.	PUNCT
eurjchem-1346	27	1	typ	typ	NOUN
eurjchem-1346	27	2	get	get	VERB
eurjchem-1346	27	3	that	that	DET
eurjchem-1346	27	4	enzyme	enzyme	NOUN
eurjchem-1346	27	5	biarylurea	biarylurea	NOUN
eurjchem-1346	27	6	de	de	AUX
eurjchem-1346	27	7	get	get	VERB
eurjchem-1346	27	8	v600ebraf	v600ebraf	NOUN
eurjchem-1346	27	9	in	in	ADP
eurjchem-1346	27	10	y.	y.	NOUN
eurjchem-1346	27	11	it	it	PRON
eurjchem-1346	27	12	has	have	VERB
eurjchem-1346	27	13	no	no	DET
eurjchem-1346	27	14	si	si	PROPN
eurjchem-1346	27	15	ase	ase	PROPN
eurjchem-1346	27	16	ii	ii	PROPN
eurjchem-1346	27	17	clinical	clinical	ADJ
eurjchem-1346	27	18	590885	590885	NUM
eurjchem-1346	27	19	,	,	PUNCT
eurjchem-1346	27	20	is	be	AUX
eurjchem-1346	27	21	cons	con	NOUN
eurjchem-1346	27	22	vitro	vitro	VERB
eurjchem-1346	27	23	,	,	PUNCT
eurjchem-1346	27	24	but	but	CCONJ
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eurjchem-1346	27	26	p	p	NOUN
eurjchem-1346	27	27	ofiles	ofile	NOUN
eurjchem-1346	27	28	in	in	ADP
eurjchem-1346	27	29	vivo	vivo	NOUN
eurjchem-1346	27	30	[	[	PUNCT
eurjchem-1346	27	31	20	20	NUM
eurjchem-1346	27	32	‐29	‐29	ADJ
eurjchem-1346	27	33	lc	lc	NOUN
eurjchem-1346	27	34	‐	‐	NOUN
eurjchem-1346	27	35	all	all	DET
eurjchem-1346	27	36	rights	right	NOUN
eurjchem-1346	27	37	re	re	NOUN
eurjchem-1346	27	38	1346	1346	NUM
eurjchem-1346	27	39	emistry	emistry	NOUN
eurjchem-1346	27	40	m	m	NOUN
eurjchem-1346	27	41	ar	ar	NOUN
eurjchem-1346	27	42	dockin	dockin	PROPN
eurjchem-1346	27	43	none	none	NOUN
eurjchem-1346	27	44	t	t	PROPN
eurjchem-1346	27	45	abdel	abdel	PROPN
eurjchem-1346	27	46	rahm	rahm	PROPN
eurjchem-1346	27	47	ypt	ypt	PROPN
eurjchem-1346	27	48	university	university	PROPN
eurjchem-1346	27	49	,	,	PUNCT
eurjchem-1346	27	50	giza	giza	PROPN
eurjchem-1346	27	51	,	,	PUNCT
eurjchem-1346	27	52	125	125	NUM
eurjchem-1346	27	53	azinone	azinone	NOUN
eurjchem-1346	27	54	derivati	derivati	NOUN
eurjchem-1346	27	55	nthesized	nthesize	VERB
eurjchem-1346	27	56	compo	compo	NOUN
eurjchem-1346	27	57	oid	oid	NOUN
eurjchem-1346	27	58	cell	cell	NOUN
eurjchem-1346	27	59	lines	line	NOUN
eurjchem-1346	27	60	(	(	PUNCT
eurjchem-1346	27	61	c	c	PROPN
eurjchem-1346	27	62	were	be	AUX
eurjchem-1346	27	63	investigat	investigat	NOUN
eurjchem-1346	27	64	was	be	AUX
eurjchem-1346	27	65	the	the	DET
eurjchem-1346	27	66	most	most	ADV
eurjchem-1346	27	67	a	a	PRON
eurjchem-1346	27	68	on	on	ADV
eurjchem-1346	27	69	,	,	PUNCT
eurjchem-1346	27	70	in	in	ADP
eurjchem-1346	27	71	vitro	vitro	X
eurjchem-1346	27	72	kinas	kinas	PROPN
eurjchem-1346	27	73	d	d	PROPN
eurjchem-1346	27	74	compounds	compound	NOUN
eurjchem-1346	27	75	.	.	PUNCT
eurjchem-1346	28	1	fu	fu	PROPN
eurjchem-1346	28	2	tive	tive	PROPN
eurjchem-1346	28	3	site	site	NOUN
eurjchem-1346	28	4	of	of	ADP
eurjchem-1346	28	5	v600e	v600e	PROPN
eurjchem-1346	28	6	g	g	PROPN
eurjchem-1346	28	7	revealed	reveal	VERB
eurjchem-1346	28	8	that	that	SCONJ
eurjchem-1346	28	9	,	,	PUNCT
eurjchem-1346	28	10	se	se	ADP
eurjchem-1346	28	11	enzyme	enzyme	NOUN
eurjchem-1346	28	12	invol	invol	NOUN
eurjchem-1346	28	13	newly	newly	ADV
eurjchem-1346	28	14	synthesize	synthesize	VERB
eurjchem-1346	28	15	with	with	ADP
eurjchem-1346	28	16	triazine	triazine	PROPN
eurjchem-1346	28	17	het	het	PROPN
eurjchem-1346	28	18	promising	promise	VERB
eurjchem-1346	28	19	cyto	cyto	PROPN
eurjchem-1346	28	20	roid	roid	PROPN
eurjchem-1346	28	21	and	and	CCONJ
eurjchem-1346	28	22	colon	colon	NOUN
eurjchem-1346	28	23	ca	can	AUX
eurjchem-1346	28	24	mmon	mmon	NOUN
eurjchem-1346	28	25	mutatio	mutatio	NOUN
eurjchem-1346	28	26	braf	braf	NOUN
eurjchem-1346	28	27	.	.	PUNCT
eurjchem-1346	29	1	v600ebra	v600ebra	NOUN
eurjchem-1346	29	2	600	600	NUM
eurjchem-1346	29	3	is	be	AUX
eurjchem-1346	29	4	replace	replace	NOUN
eurjchem-1346	29	5	djacent	djacent	NOUN
eurjchem-1346	29	6	to	to	ADP
eurjchem-1346	29	7	pho	pho	NOUN
eurjchem-1346	29	8	vation	vation	NOUN
eurjchem-1346	29	9	.	.	PUNCT
eurjchem-1346	30	1	the	the	DET
eurjchem-1346	30	2	pola	pola	PROPN
eurjchem-1346	30	3	ylated	ylate	VERB
eurjchem-1346	30	4	serine	serine	NOUN
eurjchem-1346	30	5	in	in	ADP
eurjchem-1346	30	6	af	af	PROPN
eurjchem-1346	30	7	active	active	ADJ
eurjchem-1346	30	8	and	and	CCONJ
eurjchem-1346	30	9	3	3	NUM
eurjchem-1346	30	10	]	]	PUNCT
eurjchem-1346	30	11	.	.	PUNCT
eurjchem-1346	31	1	therefore	therefore	ADV
eurjchem-1346	31	2	,	,	PUNCT
eurjchem-1346	31	3	b	b	PROPN
eurjchem-1346	31	4	c	c	PROPN
eurjchem-1346	31	5	target	target	NOUN
eurjchem-1346	31	6	in	in	ADP
eurjchem-1346	31	7	diffe	diffe	ADJ
eurjchem-1346	31	8	enzyme	enzyme	NOUN
eurjchem-1346	31	9	inhibi	inhibi	NOUN
eurjchem-1346	31	10	i	i	PRON
eurjchem-1346	31	11	inhibitors	inhibitor	NOUN
eurjchem-1346	31	12	,	,	PUNCT
eurjchem-1346	31	13	su	su	PROPN
eurjchem-1346	31	14	the	the	DET
eurjchem-1346	31	15	braf	braf	PROPN
eurjchem-1346	31	16	kin	kin	PROPN
eurjchem-1346	31	17	pe	pe	PROPN
eurjchem-1346	31	18	ii	ii	PROPN
eurjchem-1346	31	19	inhibitors	inhibitor	NOUN
eurjchem-1346	31	20	,	,	PUNCT
eurjchem-1346	31	21	e	e	NOUN
eurjchem-1346	31	22	in	in	ADP
eurjchem-1346	31	23	its	its	PRON
eurjchem-1346	31	24	inactive	inactive	ADJ
eurjchem-1346	31	25	rivative	rivative	ADJ
eurjchem-1346	31	26	,	,	PUNCT
eurjchem-1346	31	27	sorafe	sorafe	NOUN
eurjchem-1346	31	28	n	n	PRON
eurjchem-1346	31	29	melanoma	melanoma	VERB
eurjchem-1346	31	30	an	an	DET
eurjchem-1346	31	31	ignificant	ignificant	ADJ
eurjchem-1346	31	32	resp	resp	NOUN
eurjchem-1346	31	33	trials	trial	NOUN
eurjchem-1346	31	34	[	[	X
eurjchem-1346	31	35	15‐19	15‐19	NOUN
eurjchem-1346	31	36	]	]	PUNCT
eurjchem-1346	31	37	.	.	PUNCT
eurjchem-1346	32	1	sidered	sidere	VERB
eurjchem-1346	32	2	a	a	DET
eurjchem-1346	32	3	poten	poten	ADJ
eurjchem-1346	32	4	poor	poor	ADJ
eurjchem-1346	32	5	pharmaco	pharmaco	NOUN
eurjchem-1346	32	6	0	0	NUM
eurjchem-1346	32	7	]	]	PUNCT
eurjchem-1346	32	8	.	.	PUNCT
eurjchem-1346	33	1	served	serve	VERB
eurjchem-1346	33	2	‐	‐	NOUN
eurjchem-1346	33	3	printed	print	VERB
eurjchem-1346	33	4	y	y	PROPN
eurjchem-1346	33	5	ng	ng	PROPN
eurjchem-1346	33	6	of	of	ADP
eurjchem-1346	33	7	man	man	PROPN
eurjchem-1346	33	8	1	1	NUM
eurjchem-1346	33	9	,	,	PUNCT
eurjchem-1346	33	10	566	566	NUM
eurjchem-1346	33	11	,	,	PUNCT
eurjchem-1346	33	12	egypt	egypt	PROPN
eurjchem-1346	33	13	.	.	PUNCT
eurjchem-1346	34	1	ives	ive	NOUN
eurjchem-1346	34	2	as	as	ADP
eurjchem-1346	34	3	anti‐prol	anti‐prol	NOUN
eurjchem-1346	34	4	ounds	ounds	ADP
eurjchem-1346	34	5	against	against	ADP
eurjchem-1346	34	6	m	m	PROPN
eurjchem-1346	34	7	cal62	cal62	PROPN
eurjchem-1346	34	8	,	,	PUNCT
eurjchem-1346	34	9	ftc133	ftc133	PROPN
eurjchem-1346	34	10	,	,	PUNCT
eurjchem-1346	34	11	ted	ted	PROPN
eurjchem-1346	34	12	.	.	PUNCT
eurjchem-1346	35	1	results	result	NOUN
eurjchem-1346	35	2	rev	rev	VERB
eurjchem-1346	35	3	ctive	ctive	PROPN
eurjchem-1346	35	4	one	one	NUM
eurjchem-1346	35	5	.	.	PUNCT
eurjchem-1346	36	1	it	it	PRON
eurjchem-1346	36	2	exh	exh	PROPN
eurjchem-1346	36	3	se	se	PROPN
eurjchem-1346	36	4	assay	assay	VERB
eurjchem-1346	36	5	against	against	ADP
eurjchem-1346	36	6	urthermore	urthermore	NOUN
eurjchem-1346	36	7	,	,	PUNCT
eurjchem-1346	36	8	mol	mol	ADP
eurjchem-1346	36	9	ebraf	ebraf	NOUN
eurjchem-1346	36	10	kinase	kinase	PROPN
eurjchem-1346	36	11	do	do	VERB
eurjchem-1346	36	12	compounds	compound	NOUN
eurjchem-1346	36	13	1	1	NUM
eurjchem-1346	36	14	,	,	PUNCT
eurjchem-1346	36	15	3	3	NUM
eurjchem-1346	36	16	lved	lve	VERB
eurjchem-1346	36	17	in	in	ADP
eurjchem-1346	36	18	number	number	NOUN
eurjchem-1346	36	19	o	o	PROPN
eurjchem-1346	36	20	ed	ed	PROPN
eurjchem-1346	36	21	pyridopyrazin	pyridopyrazin	PROPN
eurjchem-1346	36	22	terocycle	terocycle	PROPN
eurjchem-1346	36	23	at	at	ADP
eurjchem-1346	36	24	c‐3	c‐3	ADJ
eurjchem-1346	36	25	otoxic	otoxic	ADJ
eurjchem-1346	36	26	activities	activity	NOUN
eurjchem-1346	36	27	ancer	ancer	ADV
eurjchem-1346	36	28	.	.	PUNCT
eurjchem-1346	37	1	n	n	X
eurjchem-1346	37	2	in	in	ADP
eurjchem-1346	37	3	braf	braf	NOUN
eurjchem-1346	37	4	am	be	AUX
eurjchem-1346	37	5	af	af	PROPN
eurjchem-1346	37	6	is	be	AUX
eurjchem-1346	37	7	a	a	DET
eurjchem-1346	37	8	single	single	ADJ
eurjchem-1346	37	9	ed	ed	NOUN
eurjchem-1346	37	10	with	with	ADP
eurjchem-1346	37	11	glu	glu	NOUN
eurjchem-1346	37	12	in	in	ADP
eurjchem-1346	37	13	osphorylation	osphorylation	NOUN
eurjchem-1346	37	14	t	t	NOUN
eurjchem-1346	37	15	arity	arity	NOUN
eurjchem-1346	37	16	of	of	ADP
eurjchem-1346	37	17	glutamic	glutamic	ADJ
eurjchem-1346	37	18	n	n	CCONJ
eurjchem-1346	37	19	activation	activation	NOUN
eurjchem-1346	37	20	lo	lo	PROPN
eurjchem-1346	37	21	resulted	result	VERB
eurjchem-1346	37	22	in	in	ADP
eurjchem-1346	37	23	un	un	PROPN
eurjchem-1346	37	24	braf	braf	PROPN
eurjchem-1346	37	25	kinase	kinase	PROPN
eurjchem-1346	37	26	is	be	AUX
eurjchem-1346	37	27	rent	rent	NOUN
eurjchem-1346	37	28	types	type	NOUN
eurjchem-1346	37	29	of	of	ADP
eurjchem-1346	37	30	ca	ca	NOUN
eurjchem-1346	37	31	itors	itor	NOUN
eurjchem-1346	37	32	are	be	AUX
eurjchem-1346	37	33	class	class	NOUN
eurjchem-1346	37	34	uch	uch	NOUN
eurjchem-1346	37	35	as	as	ADP
eurjchem-1346	37	36	sb5908	sb5908	PROPN
eurjchem-1346	37	37	nase	nase	PROPN
eurjchem-1346	37	38	enzyme	enzyme	NOUN
eurjchem-1346	37	39	such	such	ADJ
eurjchem-1346	37	40	as	as	ADP
eurjchem-1346	37	41	sorafe	sorafe	NOUN
eurjchem-1346	37	42	conformation	conformation	NOUN
eurjchem-1346	37	43	.	.	PUNCT
eurjchem-1346	38	1	enib	enib	PROPN
eurjchem-1346	38	2	was	be	AUX
eurjchem-1346	38	3	the	the	DET
eurjchem-1346	38	4	f	f	PROPN
eurjchem-1346	38	5	nd	nd	PRON
eurjchem-1346	38	6	exhibited	exhibit	VERB
eurjchem-1346	38	7	in	in	ADP
eurjchem-1346	38	8	onse	onse	NOUN
eurjchem-1346	38	9	in	in	ADP
eurjchem-1346	38	10	neithe	neithe	PROPN
eurjchem-1346	38	11	triarylimidaz	triarylimidaz	PROPN
eurjchem-1346	38	12	t	t	PROPN
eurjchem-1346	38	13	type	type	NOUN
eurjchem-1346	38	14	i	i	PRON
eurjchem-1346	38	15	inhibito	inhibito	VERB
eurjchem-1346	38	16	okinetic	okinetic	ADJ
eurjchem-1346	38	17	and	and	CCONJ
eurjchem-1346	38	18	ph	ph	ADJ
eurjchem-1346	38	19	d	d	PROPN
eurjchem-1346	38	20	in	in	ADP
eurjchem-1346	38	21	the	the	DET
eurjchem-1346	38	22	usa	usa	PROPN
eurjchem-1346	38	23	iferative	iferative	PROPN
eurjchem-1346	38	24	agents	agent	NOUN
eurjchem-1346	38	25	melanoma	melanoma	PROPN
eurjchem-1346	38	26	cell	cell	NOUN
eurjchem-1346	38	27	lin	lin	PROPN
eurjchem-1346	38	28	bcpap	bcpap	PROPN
eurjchem-1346	38	29	and	and	CCONJ
eurjchem-1346	38	30	ml	ml	AUX
eurjchem-1346	38	31	vealed	veale	VERB
eurjchem-1346	38	32	that	that	SCONJ
eurjchem-1346	38	33	mo	mo	PROPN
eurjchem-1346	38	34	hibited	hibite	VERB
eurjchem-1346	38	35	promisin	promisin	NOUN
eurjchem-1346	38	36	both	both	PRON
eurjchem-1346	38	37	wtbraf	wtbraf	VERB
eurjchem-1346	38	38	an	an	DET
eurjchem-1346	38	39	lecular	lecular	ADJ
eurjchem-1346	38	40	docking	docking	NOUN
eurjchem-1346	38	41	omain	omain	NOUN
eurjchem-1346	38	42	.	.	PUNCT
eurjchem-1346	39	1	results	result	NOUN
eurjchem-1346	39	2	3d	3d	NUM
eurjchem-1346	39	3	,	,	PUNCT
eurjchem-1346	39	4	e	e	NOUN
eurjchem-1346	39	5	,	,	PUNCT
eurjchem-1346	39	6	h	h	NOUN
eurjchem-1346	39	7	,	,	PUNCT
eurjchem-1346	39	8	i	i	PRON
eurjchem-1346	39	9	,	,	PUNCT
eurjchem-1346	39	10	5d	5d	NUM
eurjchem-1346	39	11	,	,	PUNCT
eurjchem-1346	39	12	e	e	X
eurjchem-1346	39	13	an	an	PRON
eurjchem-1346	39	14	of	of	ADP
eurjchem-1346	39	15	cancer	cancer	NOUN
eurjchem-1346	39	16	types	type	NOUN
eurjchem-1346	39	17	a	a	DET
eurjchem-1346	39	18	nones	none	NOUN
eurjchem-1346	39	19	substitute	substitute	NOUN
eurjchem-1346	39	20	and	and	CCONJ
eurjchem-1346	39	21	c‐4	c‐4	NOUN
eurjchem-1346	39	22	afforde	afforde	VERB
eurjchem-1346	39	23	against	against	ADP
eurjchem-1346	39	24	differe	differe	X
eurjchem-1346	39	25	mong	mong	PROPN
eurjchem-1346	39	26	95	95	NUM
eurjchem-1346	39	27	braf	braf	NOUN
eurjchem-1346	39	28	base	base	NOUN
eurjchem-1346	39	29	missense	missense	NOUN
eurjchem-1346	39	30	the	the	DET
eurjchem-1346	39	31	activation	activation	NOUN
eurjchem-1346	39	32	target	target	NOUN
eurjchem-1346	39	33	ser	ser	NOUN
eurjchem-1346	39	34	599	599	NUM
eurjchem-1346	39	35	c	c	NOUN
eurjchem-1346	39	36	acid	acid	NOUN
eurjchem-1346	39	37	is	be	AUX
eurjchem-1346	39	38	similar	similar	ADJ
eurjchem-1346	39	39	op	op	NOUN
eurjchem-1346	39	40	that	that	PRON
eurjchem-1346	39	41	led	lead	VERB
eurjchem-1346	39	42	to	to	ADP
eurjchem-1346	39	43	ncontrolled	ncontrolled	ADJ
eurjchem-1346	39	44	cell	cell	NOUN
eurjchem-1346	39	45	s	s	AUX
eurjchem-1346	39	46	considered	consider	VERB
eurjchem-1346	39	47	a	a	DET
eurjchem-1346	39	48	ancer	ancer	NOUN
eurjchem-1346	39	49	[	[	X
eurjchem-1346	39	50	14	14	NUM
eurjchem-1346	39	51	]	]	PUNCT
eurjchem-1346	39	52	.	.	PUNCT
eurjchem-1346	40	1	sified	sifie	VERB
eurjchem-1346	40	2	into	into	ADP
eurjchem-1346	40	3	two	two	NUM
eurjchem-1346	40	4	885	885	NUM
eurjchem-1346	40	5	(	(	PUNCT
eurjchem-1346	40	6	figure	figure	NOUN
eurjchem-1346	40	7	1	1	NUM
eurjchem-1346	40	8	)	)	PUNCT
eurjchem-1346	40	9	,	,	PUNCT
eurjchem-1346	40	10	in	in	ADP
eurjchem-1346	40	11	its	its	PRON
eurjchem-1346	40	12	active	active	ADJ
eurjchem-1346	40	13	enib	enib	NOUN
eurjchem-1346	40	14	(	(	PUNCT
eurjchem-1346	40	15	figure	figure	NOUN
eurjchem-1346	40	16	1	1	NUM
eurjchem-1346	40	17	)	)	PUNCT
eurjchem-1346	40	18	,	,	PUNCT
eurjchem-1346	40	19	first	first	ADJ
eurjchem-1346	40	20	drug	drug	NOUN
eurjchem-1346	40	21	that	that	PRON
eurjchem-1346	40	22	vitro	vitro	VERB
eurjchem-1346	40	23	inhibition	inhibition	NOUN
eurjchem-1346	40	24	er	er	INTJ
eurjchem-1346	40	25	phase	phase	NOUN
eurjchem-1346	40	26	i	i	PRON
eurjchem-1346	40	27	nor	nor	CCONJ
eurjchem-1346	40	28	zole	zole	NOUN
eurjchem-1346	40	29	derivative	derivative	NOUN
eurjchem-1346	40	30	,	,	PUNCT
eurjchem-1346	40	31	or	or	CCONJ
eurjchem-1346	40	32	of	of	ADP
eurjchem-1346	40	33	v600ebraf	v600ebraf	NOUN
eurjchem-1346	40	34	harmcodynamic	harmcodynamic	ADJ
eurjchem-1346	40	35	is	be	AUX
eurjchem-1346	40	36	ne	ne	ADP
eurjchem-1346	40	37	1	1	NUM
eurjchem-1346	40	38	)	)	PUNCT
eurjchem-1346	40	39	ost	ost	INTJ
eurjchem-1346	40	40	ng	ng	PROPN
eurjchem-1346	41	1	nd	nd	INTJ
eurjchem-1346	41	2	of	of	ADP
eurjchem-1346	41	3	of	of	ADP
eurjchem-1346	41	4	nd	nd	PRON
eurjchem-1346	41	5	as	as	ADP
eurjchem-1346	41	6	ed	ed	PROPN
eurjchem-1346	41	7	ed	ed	PROPN
eurjchem-1346	41	8	nt	not	PART
eurjchem-1346	41	9	f	f	PROPN
eurjchem-1346	41	10	e	e	PROPN
eurjchem-1346	41	11	n	n	CCONJ
eurjchem-1346	41	12	9	9	NUM
eurjchem-1346	41	13	r	r	NOUN
eurjchem-1346	41	14	o	o	NOUN
eurjchem-1346	41	15	l	l	NOUN
eurjchem-1346	41	16	a	a	DET
eurjchem-1346	41	17	o	o	X
eurjchem-1346	41	18	,	,	PUNCT
eurjchem-1346	41	19	e	e	PROPN
eurjchem-1346	41	20	,	,	PUNCT
eurjchem-1346	41	21	t	t	PROPN
eurjchem-1346	41	22	n	n	CCONJ
eurjchem-1346	41	23	r	r	NOUN
eurjchem-1346	41	24	,	,	PUNCT
eurjchem-1346	41	25	f	f	PROPN
eurjchem-1346	41	26	c	c	PROPN
eurjchem-1346	41	27	20	20	NUM
eurjchem-1346	42	1	amin	amin	NOUN
eurjchem-1346	42	2	et	et	PROPN
eurjchem-1346	42	3	al	al	PROPN
eurjchem-1346	42	4	.	.	PUNCT
eurjchem-1346	42	5	/	/	SYM
eurjchem-1346	42	6	european	european	PROPN
eurjchem-1346	42	7	journal	journal	PROPN
eurjchem-1346	42	8	of	of	ADP
eurjchem-1346	42	9	chemistry	chemistry	NOUN
eurjchem-1346	42	10	7	7	NUM
eurjchem-1346	42	11	(	(	PUNCT
eurjchem-1346	42	12	1	1	NUM
eurjchem-1346	42	13	)	)	PUNCT
eurjchem-1346	42	14	(	(	PUNCT
eurjchem-1346	42	15	2016	2016	NUM
eurjchem-1346	42	16	)	)	PUNCT
eurjchem-1346	42	17	19‐29	19‐29	PROPN
eurjchem-1346	42	18	sb590885	sb590885	PROPN
eurjchem-1346	42	19	sorafenib	sorafenib	PROPN
eurjchem-1346	42	20	s	s	PART
eurjchem-1346	42	21	n	n	NUM
eurjchem-1346	42	22	h	h	NOUN
eurjchem-1346	43	1	f	f	NOUN
eurjchem-1346	43	2	o	o	NOUN
eurjchem-1346	43	3	o	o	X
eurjchem-1346	44	1	n	n	X
eurjchem-1346	44	2	s	s	NOUN
eurjchem-1346	44	3	n	n	CCONJ
eurjchem-1346	44	4	n	n	PRON
eurjchem-1346	44	5	nh2	nh2	PROPN
eurjchem-1346	44	6	f	f	PROPN
eurjchem-1346	44	7	f	f	PROPN
eurjchem-1346	44	8	dabrafenib	dabrafenib	PROPN
eurjchem-1346	44	9	vemurafenib	vemurafenib	PROPN
eurjchem-1346	44	10	raf265	raf265	VERB
eurjchem-1346	44	11	cct23905	cct23905	VERB
eurjchem-1346	44	12	figure	figure	NOUN
eurjchem-1346	44	13	1	1	NUM
eurjchem-1346	44	14	.	.	PUNCT
eurjchem-1346	45	1	braf	braf	PROPN
eurjchem-1346	45	2	kinase	kinase	PROPN
eurjchem-1346	45	3	inhibitors	inhibitor	NOUN
eurjchem-1346	45	4	.	.	PUNCT
eurjchem-1346	46	1	however	however	ADV
eurjchem-1346	46	2	,	,	PUNCT
eurjchem-1346	46	3	derivatives	derivative	NOUN
eurjchem-1346	46	4	of	of	ADP
eurjchem-1346	46	5	pyrimidine	pyrimidine	NOUN
eurjchem-1346	46	6	,	,	PUNCT
eurjchem-1346	46	7	azaindole	azaindole	NOUN
eurjchem-1346	46	8	and	and	CCONJ
eurjchem-1346	46	9	benzimidazole	benzimidazole	NOUN
eurjchem-1346	46	10	such	such	ADJ
eurjchem-1346	46	11	as	as	ADP
eurjchem-1346	46	12	darafenib	darafenib	NOUN
eurjchem-1346	46	13	,	,	PUNCT
eurjchem-1346	46	14	vemurafenib	vemurafenib	NOUN
eurjchem-1346	46	15	and	and	CCONJ
eurjchem-1346	46	16	raf265	raf265	VERB
eurjchem-1346	46	17	,	,	PUNCT
eurjchem-1346	46	18	respectively	respectively	ADV
eurjchem-1346	46	19	,	,	PUNCT
eurjchem-1346	46	20	were	be	AUX
eurjchem-1346	46	21	involved	involve	VERB
eurjchem-1346	46	22	in	in	ADP
eurjchem-1346	46	23	clinical	clinical	ADJ
eurjchem-1346	46	24	trials	trial	NOUN
eurjchem-1346	46	25	as	as	SCONJ
eurjchem-1346	46	26	v600ebraf	v600ebraf	NOUN
eurjchem-1346	46	27	kinase	kinase	VERB
eurjchem-1346	46	28	inhibitors	inhibitor	NOUN
eurjchem-1346	46	29	[	[	X
eurjchem-1346	46	30	21	21	NUM
eurjchem-1346	46	31	]	]	PUNCT
eurjchem-1346	46	32	(	(	PUNCT
eurjchem-1346	46	33	figure	figure	NOUN
eurjchem-1346	46	34	1	1	NUM
eurjchem-1346	46	35	)	)	PUNCT
eurjchem-1346	46	36	.	.	PUNCT
eurjchem-1346	47	1	pyridopyrazinone	pyridopyrazinone	NOUN
eurjchem-1346	47	2	derivatives	derivative	NOUN
eurjchem-1346	47	3	had	have	VERB
eurjchem-1346	47	4	considerable	considerable	ADJ
eurjchem-1346	47	5	thera‐	thera‐	DET
eurjchem-1346	47	6	peutic	peutic	ADJ
eurjchem-1346	47	7	activities	activity	NOUN
eurjchem-1346	47	8	in	in	ADP
eurjchem-1346	47	9	the	the	DET
eurjchem-1346	47	10	treatment	treatment	NOUN
eurjchem-1346	47	11	of	of	ADP
eurjchem-1346	47	12	different	different	ADJ
eurjchem-1346	47	13	cancer	cancer	NOUN
eurjchem-1346	47	14	types	type	NOUN
eurjchem-1346	47	15	as	as	ADP
eurjchem-1346	47	16	melanoma	melanoma	NOUN
eurjchem-1346	47	17	,	,	PUNCT
eurjchem-1346	47	18	thyroid	thyroid	NOUN
eurjchem-1346	47	19	,	,	PUNCT
eurjchem-1346	47	20	colon	colon	NOUN
eurjchem-1346	47	21	,	,	PUNCT
eurjchem-1346	47	22	and	and	CCONJ
eurjchem-1346	47	23	ovarian	ovarian	ADJ
eurjchem-1346	47	24	cancer	cancer	NOUN
eurjchem-1346	47	25	through	through	ADP
eurjchem-1346	47	26	their	their	PRON
eurjchem-1346	47	27	selective	selective	ADJ
eurjchem-1346	47	28	inhibition	inhibition	NOUN
eurjchem-1346	47	29	of	of	ADP
eurjchem-1346	47	30	v600ebraf	v600ebraf	NOUN
eurjchem-1346	47	31	[	[	X
eurjchem-1346	47	32	21	21	NUM
eurjchem-1346	47	33	]	]	PUNCT
eurjchem-1346	47	34	.	.	PUNCT
eurjchem-1346	48	1	pyridopyrazinone	pyridopyrazinone	NOUN
eurjchem-1346	48	2	derivatives	derivative	NOUN
eurjchem-1346	48	3	were	be	AUX
eurjchem-1346	48	4	considered	consider	VERB
eurjchem-1346	48	5	type	type	NOUN
eurjchem-1346	48	6	ii	ii	NOUN
eurjchem-1346	48	7	inhibitors	inhibitor	NOUN
eurjchem-1346	48	8	of	of	ADP
eurjchem-1346	48	9	v600ebraf	v600ebraf	NOUN
eurjchem-1346	48	10	,	,	PUNCT
eurjchem-1346	48	11	both	both	CCONJ
eurjchem-1346	48	12	in	in	ADP
eurjchem-1346	48	13	vitro	vitro	X
eurjchem-1346	48	14	and	and	CCONJ
eurjchem-1346	48	15	in	in	ADP
eurjchem-1346	48	16	vivo	vivo	NOUN
eurjchem-1346	48	17	.	.	PUNCT
eurjchem-1346	49	1	pyridopyrazinone	pyridopyrazinone	NOUN
eurjchem-1346	49	2	activity	activity	NOUN
eurjchem-1346	49	3	was	be	AUX
eurjchem-1346	49	4	exhibited	exhibit	VERB
eurjchem-1346	49	5	through	through	ADP
eurjchem-1346	49	6	selective	selective	ADJ
eurjchem-1346	49	7	binding	binding	NOUN
eurjchem-1346	49	8	with	with	ADP
eurjchem-1346	49	9	cys	cys	PROPN
eurjchem-1346	49	10	532	532	NUM
eurjchem-1346	49	11	backbone	backbone	NOUN
eurjchem-1346	49	12	of	of	ADP
eurjchem-1346	49	13	hinge	hinge	NOUN
eurjchem-1346	49	14	region	region	NOUN
eurjchem-1346	49	15	of	of	ADP
eurjchem-1346	49	16	v600ebraf	v600ebraf	NOUN
eurjchem-1346	49	17	by	by	ADP
eurjchem-1346	49	18	hydrogen	hydrogen	NOUN
eurjchem-1346	49	19	bonding	bonding	NOUN
eurjchem-1346	50	1	[	[	X
eurjchem-1346	50	2	14,22	14,22	NUM
eurjchem-1346	50	3	]	]	X
eurjchem-1346	50	4	.	.	PUNCT
eurjchem-1346	51	1	cct23905	cct23905	PROPN
eurjchem-1346	51	2	was	be	AUX
eurjchem-1346	51	3	the	the	DET
eurjchem-1346	51	4	first	first	ADJ
eurjchem-1346	51	5	derivative	derivative	NOUN
eurjchem-1346	51	6	of	of	ADP
eurjchem-1346	51	7	pyridopyrazinones	pyridopyrazinone	NOUN
eurjchem-1346	51	8	described	describe	VERB
eurjchem-1346	51	9	for	for	ADP
eurjchem-1346	51	10	inhibiting	inhibit	VERB
eurjchem-1346	51	11	activity	activity	NOUN
eurjchem-1346	51	12	towards	towards	ADP
eurjchem-1346	51	13	oncogenic	oncogenic	ADJ
eurjchem-1346	51	14	braf	braf	NOUN
eurjchem-1346	51	15	[	[	X
eurjchem-1346	51	16	14	14	NUM
eurjchem-1346	51	17	]	]	PUNCT
eurjchem-1346	51	18	.	.	PUNCT
eurjchem-1346	52	1	accordingly	accordingly	ADV
eurjchem-1346	52	2	,	,	PUNCT
eurjchem-1346	52	3	new	new	ADJ
eurjchem-1346	52	4	pyridopyrazinones	pyridopyrazinone	NOUN
eurjchem-1346	52	5	were	be	AUX
eurjchem-1346	52	6	designed	design	VERB
eurjchem-1346	52	7	to	to	PART
eurjchem-1346	52	8	be	be	AUX
eurjchem-1346	52	9	substituted	substitute	VERB
eurjchem-1346	52	10	with	with	ADP
eurjchem-1346	52	11	different	different	ADJ
eurjchem-1346	52	12	substituents	substituent	NOUN
eurjchem-1346	52	13	at	at	ADP
eurjchem-1346	52	14	c‐3	c‐3	NOUN
eurjchem-1346	52	15	or	or	CCONJ
eurjchem-1346	52	16	fused	fuse	VERB
eurjchem-1346	52	17	with	with	ADP
eurjchem-1346	52	18	another	another	DET
eurjchem-1346	52	19	heterocycle	heterocycle	NOUN
eurjchem-1346	52	20	at	at	ADP
eurjchem-1346	52	21	c‐3	c‐3	NOUN
eurjchem-1346	52	22	and	and	CCONJ
eurjchem-1346	52	23	c‐4	c‐4	NOUN
eurjchem-1346	52	24	to	to	PART
eurjchem-1346	52	25	afford	afford	VERB
eurjchem-1346	52	26	an	an	DET
eurjchem-1346	52	27	additional	additional	ADJ
eurjchem-1346	52	28	binding	bind	VERB
eurjchem-1346	52	29	sites	site	NOUN
eurjchem-1346	52	30	that	that	PRON
eurjchem-1346	52	31	affect	affect	VERB
eurjchem-1346	52	32	mode	mode	NOUN
eurjchem-1346	52	33	of	of	ADP
eurjchem-1346	52	34	interaction	interaction	NOUN
eurjchem-1346	52	35	.	.	PUNCT
eurjchem-1346	53	1	these	these	DET
eurjchem-1346	53	2	compounds	compound	NOUN
eurjchem-1346	53	3	were	be	AUX
eurjchem-1346	53	4	evaluated	evaluate	VERB
eurjchem-1346	53	5	for	for	ADP
eurjchem-1346	53	6	their	their	PRON
eurjchem-1346	53	7	cytotoxic	cytotoxic	ADJ
eurjchem-1346	53	8	activity	activity	NOUN
eurjchem-1346	53	9	against	against	ADP
eurjchem-1346	53	10	different	different	ADJ
eurjchem-1346	53	11	cancer	cancer	NOUN
eurjchem-1346	53	12	cell	cell	NOUN
eurjchem-1346	53	13	lines	line	NOUN
eurjchem-1346	53	14	.	.	PUNCT
eurjchem-1346	54	1	in	in	ADP
eurjchem-1346	54	2	addition	addition	NOUN
eurjchem-1346	54	3	,	,	PUNCT
eurjchem-1346	54	4	in	in	ADP
eurjchem-1346	54	5	vitro	vitro	X
eurjchem-1346	54	6	kinase	kinase	PROPN
eurjchem-1346	54	7	assay	assay	PROPN
eurjchem-1346	54	8	was	be	AUX
eurjchem-1346	54	9	performed	perform	VERB
eurjchem-1346	54	10	to	to	PART
eurjchem-1346	54	11	evaluate	evaluate	VERB
eurjchem-1346	54	12	their	their	PRON
eurjchem-1346	54	13	braf	braf	NOUN
eurjchem-1346	54	14	inhibition	inhibition	NOUN
eurjchem-1346	54	15	activities	activity	NOUN
eurjchem-1346	54	16	.	.	PUNCT
eurjchem-1346	55	1	moreover	moreover	ADV
eurjchem-1346	55	2	,	,	PUNCT
eurjchem-1346	55	3	a	a	DET
eurjchem-1346	55	4	molecular	molecular	ADJ
eurjchem-1346	55	5	docking	docking	NOUN
eurjchem-1346	55	6	study	study	NOUN
eurjchem-1346	55	7	was	be	AUX
eurjchem-1346	55	8	performed	perform	VERB
eurjchem-1346	55	9	to	to	PART
eurjchem-1346	55	10	assign	assign	VERB
eurjchem-1346	55	11	the	the	DET
eurjchem-1346	55	12	binding	bind	VERB
eurjchem-1346	55	13	mode	mode	NOUN
eurjchem-1346	55	14	with	with	ADP
eurjchem-1346	55	15	active	active	ADJ
eurjchem-1346	55	16	site	site	NOUN
eurjchem-1346	55	17	of	of	ADP
eurjchem-1346	55	18	braf	braf	NOUN
eurjchem-1346	55	19	enzyme	enzyme	NOUN
eurjchem-1346	55	20	model	model	NOUN
eurjchem-1346	55	21	.	.	PUNCT
eurjchem-1346	56	1	2	2	X
eurjchem-1346	56	2	.	.	X
eurjchem-1346	56	3	experimental	experimental	ADJ
eurjchem-1346	56	4	2.1	2.1	NUM
eurjchem-1346	56	5	.	.	PUNCT
eurjchem-1346	57	1	chemistry	chemistry	NOUN
eurjchem-1346	57	2	melting	melting	NOUN
eurjchem-1346	57	3	points	point	NOUN
eurjchem-1346	57	4	were	be	AUX
eurjchem-1346	57	5	determined	determine	VERB
eurjchem-1346	57	6	by	by	ADP
eurjchem-1346	57	7	open	open	ADJ
eurjchem-1346	57	8	capillary	capillary	ADJ
eurjchem-1346	57	9	tube	tube	NOUN
eurjchem-1346	57	10	method	method	NOUN
eurjchem-1346	57	11	using	use	VERB
eurjchem-1346	57	12	gallen	gallen	PROPN
eurjchem-1346	57	13	kamp	kamp	PROPN
eurjchem-1346	57	14	melting	melting	NOUN
eurjchem-1346	57	15	point	point	NOUN
eurjchem-1346	57	16	apparatus	apparatus	NOUN
eurjchem-1346	57	17	mfb‐595‐	mfb‐595‐	NOUN
eurjchem-1346	57	18	010	010	NUM
eurjchem-1346	57	19	m	m	VERB
eurjchem-1346	57	20	(	(	PUNCT
eurjchem-1346	57	21	gallen	gallen	PROPN
eurjchem-1346	57	22	kamp	kamp	PROPN
eurjchem-1346	57	23	,	,	PUNCT
eurjchem-1346	57	24	london	london	PROPN
eurjchem-1346	57	25	,	,	PUNCT
eurjchem-1346	57	26	england	england	PROPN
eurjchem-1346	57	27	)	)	PUNCT
eurjchem-1346	57	28	and	and	CCONJ
eurjchem-1346	57	29	were	be	AUX
eurjchem-1346	57	30	uncorrected	uncorrecte	VERB
eurjchem-1346	57	31	.	.	PUNCT
eurjchem-1346	58	1	microanalysis	microanalysis	PROPN
eurjchem-1346	58	2	was	be	AUX
eurjchem-1346	58	3	carried	carry	VERB
eurjchem-1346	58	4	out	out	ADP
eurjchem-1346	58	5	at	at	ADP
eurjchem-1346	58	6	the	the	DET
eurjchem-1346	58	7	regional	regional	ADJ
eurjchem-1346	58	8	center	center	NOUN
eurjchem-1346	58	9	for	for	ADP
eurjchem-1346	58	10	mycology	mycology	NOUN
eurjchem-1346	58	11	and	and	CCONJ
eurjchem-1346	58	12	biotechnology	biotechnology	NOUN
eurjchem-1346	58	13	,	,	PUNCT
eurjchem-1346	58	14	al‐azhar	al‐azhar	PROPN
eurjchem-1346	58	15	university	university	PROPN
eurjchem-1346	58	16	.	.	PUNCT
eurjchem-1346	59	1	ir	ir	PROPN
eurjchem-1346	59	2	spectra	spectra	PROPN
eurjchem-1346	59	3	were	be	AUX
eurjchem-1346	59	4	recorded	record	VERB
eurjchem-1346	59	5	as	as	ADP
eurjchem-1346	59	6	potassium	potassium	NOUN
eurjchem-1346	59	7	bromide	bromide	NOUN
eurjchem-1346	59	8	discs	disc	NOUN
eurjchem-1346	59	9	on	on	ADP
eurjchem-1346	59	10	schimadzu	schimadzu	PROPN
eurjchem-1346	59	11	ft‐	ft‐	PROPN
eurjchem-1346	59	12	ir	ir	PROPN
eurjchem-1346	59	13	8400s	8400s	NUM
eurjchem-1346	59	14	spectrophotometer	spectrophotometer	X
eurjchem-1346	59	15	(	(	PUNCT
eurjchem-1346	59	16	shimadzu	shimadzu	PROPN
eurjchem-1346	59	17	,	,	PUNCT
eurjchem-1346	59	18	kyoto	kyoto	PROPN
eurjchem-1346	59	19	,	,	PUNCT
eurjchem-1346	59	20	japan	japan	PROPN
eurjchem-1346	59	21	)	)	PUNCT
eurjchem-1346	59	22	and	and	CCONJ
eurjchem-1346	59	23	expressed	express	VERB
eurjchem-1346	59	24	in	in	ADP
eurjchem-1346	59	25	wavenumber	wavenumber	NOUN
eurjchem-1346	59	26	(	(	PUNCT
eurjchem-1346	59	27	ν	ν	NOUN
eurjchem-1346	59	28	)	)	PUNCT
eurjchem-1346	59	29	cm‐1	cm‐1	NOUN
eurjchem-1346	59	30	.	.	PUNCT
eurjchem-1346	60	1	the	the	DET
eurjchem-1346	60	2	1h	1h	NUM
eurjchem-1346	60	3	nmr	nmr	NOUN
eurjchem-1346	60	4	spectra	spectra	NOUN
eurjchem-1346	60	5	were	be	AUX
eurjchem-1346	60	6	recorded	record	VERB
eurjchem-1346	60	7	on	on	ADP
eurjchem-1346	60	8	a	a	DET
eurjchem-1346	60	9	bruker	bruker	ADJ
eurjchem-1346	60	10	nmr	nmr	NOUN
eurjchem-1346	60	11	spectrometer	spectrometer	NOUN
eurjchem-1346	60	12	at	at	ADP
eurjchem-1346	60	13	400	400	NUM
eurjchem-1346	60	14	mhz	mhz	ADJ
eurjchem-1346	60	15	and	and	CCONJ
eurjchem-1346	60	16	varian	varian	PROPN
eurjchem-1346	60	17	mercury	mercury	NOUN
eurjchem-1346	60	18	vx‐300	vx‐300	PROPN
eurjchem-1346	60	19	nmr	nmr	NOUN
eurjchem-1346	60	20	spectrometer	spectrometer	NOUN
eurjchem-1346	60	21	at	at	ADP
eurjchem-1346	60	22	300	300	NUM
eurjchem-1346	60	23	mhz	mhz	NOUN
eurjchem-1346	60	24	.	.	PUNCT
eurjchem-1346	61	1	chemical	chemical	ADJ
eurjchem-1346	61	2	shifts	shift	NOUN
eurjchem-1346	61	3	are	be	AUX
eurjchem-1346	61	4	quoted	quote	VERB
eurjchem-1346	61	5	in	in	ADP
eurjchem-1346	61	6	δ	δ	PROPN
eurjchem-1346	61	7	as	as	ADP
eurjchem-1346	61	8	parts	part	NOUN
eurjchem-1346	61	9	per	per	ADP
eurjchem-1346	61	10	million	million	NUM
eurjchem-1346	61	11	(	(	PUNCT
eurjchem-1346	61	12	ppm	ppm	NOUN
eurjchem-1346	61	13	)	)	PUNCT
eurjchem-1346	61	14	downfield	downfield	VERB
eurjchem-1346	61	15	from	from	ADP
eurjchem-1346	61	16	tetramethylsilane	tetramethylsilane	PROPN
eurjchem-1346	61	17	(	(	PUNCT
eurjchem-1346	61	18	tms	tms	PROPN
eurjchem-1346	61	19	)	)	PUNCT
eurjchem-1346	61	20	as	as	ADP
eurjchem-1346	61	21	internal	internal	ADJ
eurjchem-1346	61	22	standard	standard	NOUN
eurjchem-1346	61	23	.	.	PUNCT
eurjchem-1346	62	1	mass	mass	PROPN
eurjchem-1346	62	2	spectra	spectra	PROPN
eurjchem-1346	62	3	were	be	AUX
eurjchem-1346	62	4	recorded	record	VERB
eurjchem-1346	62	5	using	use	VERB
eurjchem-1346	62	6	shimadzu	shimadzu	ADJ
eurjchem-1346	62	7	gas	gas	NOUN
eurjchem-1346	62	8	chroma‐	chroma‐	NOUN
eurjchem-1346	62	9	tograph	tograph	NOUN
eurjchem-1346	62	10	mass	mass	NOUN
eurjchem-1346	62	11	spectrometer	spectrometer	NOUN
eurjchem-1346	62	12	qp	qp	ADP
eurjchem-1346	62	13	1000	1000	NUM
eurjchem-1346	62	14	ex	ex	X
eurjchem-1346	62	15	(	(	PUNCT
eurjchem-1346	62	16	shimadzu	shimadzu	NOUN
eurjchem-1346	62	17	)	)	PUNCT
eurjchem-1346	62	18	.	.	PUNCT
eurjchem-1346	63	1	tlc	tlc	PROPN
eurjchem-1346	63	2	was	be	AUX
eurjchem-1346	63	3	carried	carry	VERB
eurjchem-1346	63	4	out	out	ADP
eurjchem-1346	63	5	using	use	VERB
eurjchem-1346	63	6	art	art	NOUN
eurjchem-1346	63	7	.	.	PUNCT
eurjchem-1346	64	1	dc‐plastikfolien	dc‐plastikfolien	PROPN
eurjchem-1346	64	2	,	,	PUNCT
eurjchem-1346	64	3	kieselgel	kieselgel	NOUN
eurjchem-1346	64	4	60f254	60f254	NOUN
eurjchem-1346	64	5	sheets	sheet	NOUN
eurjchem-1346	64	6	(	(	PUNCT
eurjchem-1346	64	7	merck	merck	PROPN
eurjchem-1346	64	8	,	,	PUNCT
eurjchem-1346	64	9	darmstadt	darmstadt	PROPN
eurjchem-1346	64	10	,	,	PUNCT
eurjchem-1346	64	11	germany	germany	PROPN
eurjchem-1346	64	12	)	)	PUNCT
eurjchem-1346	64	13	,	,	PUNCT
eurjchem-1346	64	14	the	the	DET
eurjchem-1346	64	15	developing	develop	VERB
eurjchem-1346	64	16	solvent	solvent	NOUN
eurjchem-1346	64	17	was	be	AUX
eurjchem-1346	64	18	chloroform	chloroform	NOUN
eurjchem-1346	64	19	/	/	SYM
eurjchem-1346	64	20	methanol	methanol	NOUN
eurjchem-1346	64	21	(	(	PUNCT
eurjchem-1346	64	22	9:1	9:1	NUM
eurjchem-1346	64	23	,	,	PUNCT
eurjchem-1346	64	24	v	v	NOUN
eurjchem-1346	64	25	:	:	PUNCT
eurjchem-1346	64	26	v	v	NOUN
eurjchem-1346	64	27	)	)	PUNCT
eurjchem-1346	64	28	and	and	CCONJ
eurjchem-1346	64	29	the	the	DET
eurjchem-1346	64	30	spots	spot	NOUN
eurjchem-1346	64	31	were	be	AUX
eurjchem-1346	64	32	visualized	visualize	VERB
eurjchem-1346	64	33	at	at	ADP
eurjchem-1346	64	34	366	366	NUM
eurjchem-1346	64	35	and	and	CCONJ
eurjchem-1346	64	36	254	254	NUM
eurjchem-1346	64	37	nm	nm	NOUN
eurjchem-1346	64	38	by	by	ADP
eurjchem-1346	64	39	uv	uv	NOUN
eurjchem-1346	64	40	vilber	vilber	NOUN
eurjchem-1346	64	41	lourmat	lourmat	ADJ
eurjchem-1346	64	42	77202	77202	NUM
eurjchem-1346	64	43	(	(	PUNCT
eurjchem-1346	64	44	vilber	vilber	NOUN
eurjchem-1346	64	45	,	,	PUNCT
eurjchem-1346	64	46	marne	marne	PROPN
eurjchem-1346	64	47	la	la	PROPN
eurjchem-1346	64	48	vallee	vallee	PROPN
eurjchem-1346	64	49	,	,	PUNCT
eurjchem-1346	64	50	france	france	PROPN
eurjchem-1346	64	51	)	)	PUNCT
eurjchem-1346	64	52	.	.	PUNCT
eurjchem-1346	65	1	2.1.1	2.1.1	X
eurjchem-1346	65	2	.	.	X
eurjchem-1346	66	1	synthesis	synthesis	NOUN
eurjchem-1346	66	2	of	of	ADP
eurjchem-1346	66	3	3‐methylpyrido[2,3‐b]pyrazin‐2(1h)one	3‐methylpyrido[2,3‐b]pyrazin‐2(1h)one	NUM
eurjchem-1346	66	4	(	(	PUNCT
eurjchem-1346	66	5	1	1	NUM
eurjchem-1346	66	6	)	)	PUNCT
eurjchem-1346	66	7	ethyl	ethyl	PROPN
eurjchem-1346	66	8	pyruvate	pyruvate	NOUN
eurjchem-1346	66	9	(	(	PUNCT
eurjchem-1346	66	10	2.90	2.90	NUM
eurjchem-1346	66	11	g	g	NOUN
eurjchem-1346	66	12	,	,	PUNCT
eurjchem-1346	66	13	2.77	2.77	NUM
eurjchem-1346	66	14	ml	ml	NOUN
eurjchem-1346	66	15	,	,	PUNCT
eurjchem-1346	66	16	0.025	0.025	NUM
eurjchem-1346	66	17	mol	mol	NOUN
eurjchem-1346	66	18	)	)	PUNCT
eurjchem-1346	66	19	was	be	AUX
eurjchem-1346	66	20	added	add	VERB
eurjchem-1346	66	21	to	to	ADP
eurjchem-1346	66	22	a	a	DET
eurjchem-1346	66	23	solution	solution	NOUN
eurjchem-1346	66	24	of	of	ADP
eurjchem-1346	66	25	2,3‐diaminopyridine	2,3‐diaminopyridine	NUM
eurjchem-1346	66	26	(	(	PUNCT
eurjchem-1346	66	27	2.75	2.75	NUM
eurjchem-1346	66	28	g	g	NOUN
eurjchem-1346	66	29	,	,	PUNCT
eurjchem-1346	66	30	0.025	0.025	NUM
eurjchem-1346	66	31	mol	mol	NOUN
eurjchem-1346	66	32	)	)	PUNCT
eurjchem-1346	66	33	in	in	ADP
eurjchem-1346	66	34	ethanol	ethanol	NOUN
eurjchem-1346	66	35	(	(	PUNCT
eurjchem-1346	66	36	30	30	NUM
eurjchem-1346	66	37	ml	ml	NOUN
eurjchem-1346	66	38	)	)	PUNCT
eurjchem-1346	66	39	and	and	CCONJ
eurjchem-1346	66	40	refluxed	refluxe	VERB
eurjchem-1346	66	41	for	for	ADP
eurjchem-1346	66	42	10	10	NUM
eurjchem-1346	66	43	h.	h.	PROPN
eurjchem-1346	66	44	reaction	reaction	NOUN
eurjchem-1346	66	45	mixture	mixture	NOUN
eurjchem-1346	66	46	was	be	AUX
eurjchem-1346	66	47	cooled	cool	VERB
eurjchem-1346	66	48	,	,	PUNCT
eurjchem-1346	66	49	filtered	filter	VERB
eurjchem-1346	66	50	,	,	PUNCT
eurjchem-1346	66	51	washed	wash	VERB
eurjchem-1346	66	52	with	with	ADP
eurjchem-1346	66	53	ethanol	ethanol	NOUN
eurjchem-1346	66	54	(	(	PUNCT
eurjchem-1346	66	55	5	5	NUM
eurjchem-1346	66	56	ml	ml	NOUN
eurjchem-1346	66	57	)	)	PUNCT
eurjchem-1346	66	58	and	and	CCONJ
eurjchem-1346	66	59	dried	dry	VERB
eurjchem-1346	66	60	.	.	PUNCT
eurjchem-1346	67	1	the	the	DET
eurjchem-1346	67	2	crude	crude	ADJ
eurjchem-1346	67	3	product	product	NOUN
eurjchem-1346	67	4	was	be	AUX
eurjchem-1346	67	5	crystalized	crystalize	VERB
eurjchem-1346	67	6	from	from	ADP
eurjchem-1346	67	7	ethanol	ethanol	NOUN
eurjchem-1346	67	8	(	(	PUNCT
eurjchem-1346	67	9	scheme	scheme	NOUN
eurjchem-1346	67	10	1	1	NUM
eurjchem-1346	67	11	)	)	PUNCT
eurjchem-1346	67	12	.	.	PUNCT
eurjchem-1346	68	1	yield	yield	NOUN
eurjchem-1346	68	2	:	:	PUNCT
eurjchem-1346	68	3	59	59	NUM
eurjchem-1346	68	4	%	%	NOUN
eurjchem-1346	68	5	.	.	PUNCT
eurjchem-1346	69	1	m.p	m.p	PROPN
eurjchem-1346	69	2	.	.	PROPN
eurjchem-1346	69	3	:	:	PUNCT
eurjchem-1346	70	1	278‐280	278‐280	NUM
eurjchem-1346	70	2	°	°	ADP
eurjchem-1346	70	3	c	c	X
eurjchem-1346	70	4	.	.	PUNCT
eurjchem-1346	71	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	71	2	(	(	PUNCT
eurjchem-1346	71	3	kbr	kbr	PROPN
eurjchem-1346	71	4	,	,	PUNCT
eurjchem-1346	71	5			PROPN
eurjchem-1346	71	6	,	,	PUNCT
eurjchem-1346	71	7	cm‐1	cm‐1	PROPN
eurjchem-1346	71	8	):	):	PUNCT
eurjchem-1346	71	9	3186	3186	NUM
eurjchem-1346	71	10	(	(	PUNCT
eurjchem-1346	71	11	nh	nh	NOUN
eurjchem-1346	71	12	)	)	PUNCT
eurjchem-1346	71	13	,	,	PUNCT
eurjchem-1346	71	14	3018	3018	NUM
eurjchem-1346	71	15	(	(	PUNCT
eurjchem-1346	71	16	ch	ch	PROPN
eurjchem-1346	71	17	ar	ar	PROPN
eurjchem-1346	71	18	)	)	PUNCT
eurjchem-1346	71	19	,	,	PUNCT
eurjchem-1346	71	20	2943	2943	NUM
eurjchem-1346	71	21	,	,	PUNCT
eurjchem-1346	71	22	2839	2839	NUM
eurjchem-1346	71	23	(	(	PUNCT
eurjchem-1346	71	24	ch	ch	NOUN
eurjchem-1346	71	25	aliph	aliph	PROPN
eurjchem-1346	71	26	)	)	PUNCT
eurjchem-1346	71	27	,	,	PUNCT
eurjchem-1346	71	28	1685	1685	NUM
eurjchem-1346	71	29	(	(	PUNCT
eurjchem-1346	71	30	c	c	NOUN
eurjchem-1346	71	31	=	=	NOUN
eurjchem-1346	71	32	o	o	NOUN
eurjchem-1346	71	33	)	)	PUNCT
eurjchem-1346	71	34	,	,	PUNCT
eurjchem-1346	71	35	1641	1641	NUM
eurjchem-1346	71	36	,	,	PUNCT
eurjchem-1346	71	37	1631	1631	NUM
eurjchem-1346	71	38	,	,	PUNCT
eurjchem-1346	71	39	1597	1597	NUM
eurjchem-1346	71	40	,	,	PUNCT
eurjchem-1346	71	41	1559	1559	NUM
eurjchem-1346	71	42	,	,	PUNCT
eurjchem-1346	71	43	1546	1546	NUM
eurjchem-1346	71	44	,	,	PUNCT
eurjchem-1346	71	45	1527	1527	NUM
eurjchem-1346	71	46	(	(	PUNCT
eurjchem-1346	71	47	c	c	NOUN
eurjchem-1346	71	48	=	=	SYM
eurjchem-1346	71	49	n	n	X
eurjchem-1346	71	50	,	,	PUNCT
eurjchem-1346	71	51	nh	nh	PROPN
eurjchem-1346	71	52	,	,	PUNCT
eurjchem-1346	71	53	c	c	X
eurjchem-1346	71	54	=	=	SYM
eurjchem-1346	71	55	c	c	NOUN
eurjchem-1346	71	56	)	)	PUNCT
eurjchem-1346	71	57	.	.	PUNCT
eurjchem-1346	72	1	1h	1h	NUM
eurjchem-1346	72	2	nmr	nmr	NOUN
eurjchem-1346	72	3	(	(	PUNCT
eurjchem-1346	72	4	300	300	NUM
eurjchem-1346	72	5	mhz	mhz	NOUN
eurjchem-1346	72	6	,	,	PUNCT
eurjchem-1346	72	7	dmso‐	dmso‐	NUM
eurjchem-1346	72	8	d6	d6	NOUN
eurjchem-1346	72	9	,	,	PUNCT
eurjchem-1346	72	10	δ	δ	PROPN
eurjchem-1346	72	11	,	,	PUNCT
eurjchem-1346	72	12	ppm	ppm	NUM
eurjchem-1346	72	13	):	):	PUNCT
eurjchem-1346	72	14	2.41	2.41	NUM
eurjchem-1346	72	15	(	(	PUNCT
eurjchem-1346	72	16	s	s	PROPN
eurjchem-1346	72	17	,	,	PUNCT
eurjchem-1346	72	18	3h	3h	NUM
eurjchem-1346	72	19	,	,	PUNCT
eurjchem-1346	72	20	ch3	ch3	PROPN
eurjchem-1346	72	21	)	)	PUNCT
eurjchem-1346	72	22	,	,	PUNCT
eurjchem-1346	72	23	7.48	7.48	NUM
eurjchem-1346	72	24	(	(	PUNCT
eurjchem-1346	72	25	d	d	NOUN
eurjchem-1346	72	26	,	,	PUNCT
eurjchem-1346	72	27	j=	j=	ADP
eurjchem-1346	72	28	8.4	8.4	NUM
eurjchem-1346	72	29	hz	hz	NOUN
eurjchem-1346	72	30	,	,	PUNCT
eurjchem-1346	72	31	1h	1h	NUM
eurjchem-1346	72	32	,	,	PUNCT
eurjchem-1346	72	33	h‐8ar	h‐8ar	NOUN
eurjchem-1346	72	34	)	)	PUNCT
eurjchem-1346	72	35	,	,	PUNCT
eurjchem-1346	72	36	7.67	7.67	NUM
eurjchem-1346	72	37	(	(	PUNCT
eurjchem-1346	72	38	t	t	PROPN
eurjchem-1346	72	39	,	,	PUNCT
eurjchem-1346	72	40	1h	1h	NUM
eurjchem-1346	72	41	,	,	PUNCT
eurjchem-1346	72	42	h‐7ar	h‐7ar	NOUN
eurjchem-1346	72	43	)	)	PUNCT
eurjchem-1346	72	44	,	,	PUNCT
eurjchem-1346	72	45	8.11	8.11	NUM
eurjchem-1346	72	46	(	(	PUNCT
eurjchem-1346	72	47	d	d	NOUN
eurjchem-1346	72	48	,	,	PUNCT
eurjchem-1346	72	49	j=	j=	PROPN
eurjchem-1346	72	50	7.6	7.6	NUM
eurjchem-1346	72	51	hz	hz	NOUN
eurjchem-1346	72	52	,	,	PUNCT
eurjchem-1346	72	53	1h	1h	NUM
eurjchem-1346	72	54	,	,	PUNCT
eurjchem-1346	72	55	h‐6ar	h‐6ar	NOUN
eurjchem-1346	72	56	)	)	PUNCT
eurjchem-1346	72	57	,	,	PUNCT
eurjchem-1346	72	58	12.44	12.44	NUM
eurjchem-1346	72	59	(	(	PUNCT
eurjchem-1346	72	60	s	s	PROPN
eurjchem-1346	72	61	,	,	PUNCT
eurjchem-1346	72	62	1h	1h	NUM
eurjchem-1346	72	63	,	,	PUNCT
eurjchem-1346	72	64	nh	nh	PROPN
eurjchem-1346	72	65	,	,	PUNCT
eurjchem-1346	72	66	exchanged	exchange	VERB
eurjchem-1346	72	67	with	with	ADP
eurjchem-1346	72	68	d2o	d2o	NOUN
eurjchem-1346	72	69	)	)	PUNCT
eurjchem-1346	72	70	.	.	PUNCT
eurjchem-1346	73	1	anal	anal	PROPN
eurjchem-1346	73	2	.	.	PUNCT
eurjchem-1346	73	3	calcd	calcd	NOUN
eurjchem-1346	73	4	.	.	PUNCT
eurjchem-1346	74	1	for	for	SCONJ
eurjchem-1346	74	2	c8h7n3o	c8h7n3o	PROPN
eurjchem-1346	74	3	:	:	PUNCT
eurjchem-1346	74	4	c	c	X
eurjchem-1346	74	5	,	,	PUNCT
eurjchem-1346	74	6	59.62	59.62	NUM
eurjchem-1346	74	7	;	;	PUNCT
eurjchem-1346	74	8	h	h	NOUN
eurjchem-1346	74	9	,	,	PUNCT
eurjchem-1346	74	10	4.38	4.38	NUM
eurjchem-1346	74	11	;	;	PUNCT
eurjchem-1346	74	12	n	n	CCONJ
eurjchem-1346	74	13	,	,	PUNCT
eurjchem-1346	74	14	26.07	26.07	NUM
eurjchem-1346	74	15	.	.	PUNCT
eurjchem-1346	74	16	found	find	VERB
eurjchem-1346	74	17	:	:	PUNCT
eurjchem-1346	75	1	c	c	X
eurjchem-1346	75	2	,	,	PUNCT
eurjchem-1346	75	3	59.90	59.90	NUM
eurjchem-1346	75	4	;	;	PUNCT
eurjchem-1346	75	5	h	h	NOUN
eurjchem-1346	75	6	,	,	PUNCT
eurjchem-1346	75	7	4.14	4.14	NUM
eurjchem-1346	75	8	;	;	PUNCT
eurjchem-1346	75	9	n	n	CCONJ
eurjchem-1346	75	10	,	,	PUNCT
eurjchem-1346	75	11	26.73	26.73	NUM
eurjchem-1346	75	12	%	%	NOUN
eurjchem-1346	75	13	.	.	PUNCT
eurjchem-1346	76	1	2.1.2	2.1.2	X
eurjchem-1346	76	2	.	.	X
eurjchem-1346	76	3	synthesis	synthesis	NOUN
eurjchem-1346	76	4	of	of	ADP
eurjchem-1346	76	5	3‐bromomethylpyrido[2,3‐b]pyrazin‐2	3‐bromomethylpyrido[2,3‐b]pyrazin‐2	NUM
eurjchem-1346	76	6	(	(	PUNCT
eurjchem-1346	76	7	1h)one	1h)one	NUM
eurjchem-1346	76	8	(	(	PUNCT
eurjchem-1346	76	9	2	2	NUM
eurjchem-1346	76	10	)	)	PUNCT
eurjchem-1346	76	11	compound	compound	NOUN
eurjchem-1346	76	12	1	1	NUM
eurjchem-1346	76	13	(	(	PUNCT
eurjchem-1346	76	14	3.22	3.22	NUM
eurjchem-1346	76	15	g	g	NOUN
eurjchem-1346	76	16	,	,	PUNCT
eurjchem-1346	76	17	0.02	0.02	NUM
eurjchem-1346	76	18	mol	mol	NOUN
eurjchem-1346	76	19	)	)	PUNCT
eurjchem-1346	76	20	was	be	AUX
eurjchem-1346	76	21	dissolved	dissolve	VERB
eurjchem-1346	76	22	in	in	ADP
eurjchem-1346	76	23	glacial	glacial	ADJ
eurjchem-1346	76	24	acetic	acetic	ADJ
eurjchem-1346	76	25	acid	acid	NOUN
eurjchem-1346	76	26	(	(	PUNCT
eurjchem-1346	76	27	10	10	NUM
eurjchem-1346	76	28	ml	ml	NOUN
eurjchem-1346	76	29	)	)	PUNCT
eurjchem-1346	76	30	and	and	CCONJ
eurjchem-1346	76	31	anhydrous	anhydrous	ADJ
eurjchem-1346	76	32	sodium	sodium	NOUN
eurjchem-1346	76	33	acetate	acetate	NOUN
eurjchem-1346	76	34	(	(	PUNCT
eurjchem-1346	76	35	1.64	1.64	NUM
eurjchem-1346	76	36	g	g	NOUN
eurjchem-1346	76	37	,	,	PUNCT
eurjchem-1346	76	38	0.02	0.02	NUM
eurjchem-1346	76	39	mol	mol	NOUN
eurjchem-1346	76	40	)	)	PUNCT
eurjchem-1346	76	41	was	be	AUX
eurjchem-1346	76	42	added	add	VERB
eurjchem-1346	76	43	.	.	PUNCT
eurjchem-1346	77	1	bromine	bromine	NOUN
eurjchem-1346	77	2	(	(	PUNCT
eurjchem-1346	77	3	3.04	3.04	NUM
eurjchem-1346	77	4	g	g	NOUN
eurjchem-1346	77	5	,	,	PUNCT
eurjchem-1346	77	6	0.99	0.99	NUM
eurjchem-1346	77	7	ml	ml	NOUN
eurjchem-1346	77	8	,	,	PUNCT
eurjchem-1346	77	9	0.019	0.019	NUM
eurjchem-1346	77	10	mol	mol	NOUN
eurjchem-1346	77	11	)	)	PUNCT
eurjchem-1346	77	12	was	be	AUX
eurjchem-1346	77	13	added	add	VERB
eurjchem-1346	77	14	dropwise	dropwise	NOUN
eurjchem-1346	77	15	and	and	CCONJ
eurjchem-1346	77	16	the	the	DET
eurjchem-1346	77	17	mixture	mixture	NOUN
eurjchem-1346	77	18	was	be	AUX
eurjchem-1346	77	19	heated	heat	VERB
eurjchem-1346	77	20	on	on	ADP
eurjchem-1346	77	21	steam	steam	NOUN
eurjchem-1346	77	22	bath	bath	NOUN
eurjchem-1346	77	23	for	for	ADP
eurjchem-1346	77	24	30	30	NUM
eurjchem-1346	77	25	min	min	NOUN
eurjchem-1346	77	26	.	.	PROPN
eurjchem-1346	77	27	then	then	ADV
eurjchem-1346	77	28	cooled	cool	VERB
eurjchem-1346	77	29	.	.	PUNCT
eurjchem-1346	78	1	the	the	DET
eurjchem-1346	78	2	formed	form	VERB
eurjchem-1346	78	3	precipitate	precipitate	NOUN
eurjchem-1346	78	4	was	be	AUX
eurjchem-1346	78	5	filtered	filter	VERB
eurjchem-1346	78	6	,	,	PUNCT
eurjchem-1346	78	7	washed	wash	VERB
eurjchem-1346	78	8	with	with	ADP
eurjchem-1346	78	9	glacial	glacial	ADJ
eurjchem-1346	78	10	acetic	acetic	ADJ
eurjchem-1346	78	11	acid	acid	NOUN
eurjchem-1346	78	12	(	(	PUNCT
eurjchem-1346	78	13	5	5	NUM
eurjchem-1346	78	14	ml	ml	NOUN
eurjchem-1346	78	15	)	)	PUNCT
eurjchem-1346	78	16	and	and	CCONJ
eurjchem-1346	78	17	dried	dry	VERB
eurjchem-1346	78	18	.	.	PUNCT
eurjchem-1346	79	1	the	the	DET
eurjchem-1346	79	2	crude	crude	ADJ
eurjchem-1346	79	3	product	product	NOUN
eurjchem-1346	79	4	was	be	AUX
eurjchem-1346	79	5	crystalized	crystalize	VERB
eurjchem-1346	79	6	from	from	ADP
eurjchem-1346	79	7	ethanol	ethanol	NOUN
eurjchem-1346	79	8	(	(	PUNCT
eurjchem-1346	79	9	scheme	scheme	NOUN
eurjchem-1346	79	10	1	1	NUM
eurjchem-1346	79	11	)	)	PUNCT
eurjchem-1346	79	12	.	.	PUNCT
eurjchem-1346	80	1	yield	yield	NOUN
eurjchem-1346	80	2	:	:	PUNCT
eurjchem-1346	80	3	43	43	NUM
eurjchem-1346	80	4	%	%	NOUN
eurjchem-1346	80	5	.	.	PUNCT
eurjchem-1346	81	1	m.p	m.p	PROPN
eurjchem-1346	81	2	.	.	PROPN
eurjchem-1346	81	3	:	:	PUNCT
eurjchem-1346	82	1	237‐239	237‐239	NUM
eurjchem-1346	82	2	°	°	SYM
eurjchem-1346	82	3	c	c	NOUN
eurjchem-1346	82	4	.	.	PUNCT
eurjchem-1346	83	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	83	2	(	(	PUNCT
eurjchem-1346	83	3	kbr	kbr	PROPN
eurjchem-1346	83	4	,	,	PUNCT
eurjchem-1346	83	5			PROPN
eurjchem-1346	83	6	,	,	PUNCT
eurjchem-1346	83	7	cm‐1	cm‐1	PROPN
eurjchem-1346	83	8	):	):	PUNCT
eurjchem-1346	83	9	3414	3414	NUM
eurjchem-1346	83	10	(	(	PUNCT
eurjchem-1346	83	11	nh	nh	NOUN
eurjchem-1346	83	12	)	)	PUNCT
eurjchem-1346	83	13	,	,	PUNCT
eurjchem-1346	83	14	3055	3055	NUM
eurjchem-1346	83	15	(	(	PUNCT
eurjchem-1346	83	16	ch	ch	PROPN
eurjchem-1346	83	17	ar	ar	PROPN
eurjchem-1346	83	18	)	)	PUNCT
eurjchem-1346	83	19	,	,	PUNCT
eurjchem-1346	83	20	2980	2980	NUM
eurjchem-1346	83	21	,	,	PUNCT
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eurjchem-1346	83	24	ch	ch	NOUN
eurjchem-1346	83	25	aliph	aliph	PROPN
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eurjchem-1346	83	27	,	,	PUNCT
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eurjchem-1346	83	29	(	(	PUNCT
eurjchem-1346	83	30	c	c	NOUN
eurjchem-1346	83	31	=	=	NOUN
eurjchem-1346	83	32	o	o	NOUN
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eurjchem-1346	83	34	,	,	PUNCT
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eurjchem-1346	83	36	,	,	PUNCT
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eurjchem-1346	83	38	,	,	PUNCT
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eurjchem-1346	83	40	,	,	PUNCT
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eurjchem-1346	83	42	,	,	PUNCT
eurjchem-1346	83	43	1508	1508	NUM
eurjchem-1346	83	44	(	(	PUNCT
eurjchem-1346	83	45	c	c	NOUN
eurjchem-1346	83	46	=	=	SYM
eurjchem-1346	83	47	n	n	X
eurjchem-1346	83	48	,	,	PUNCT
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eurjchem-1346	83	50	,	,	PUNCT
eurjchem-1346	83	51	c	c	X
eurjchem-1346	83	52	=	=	SYM
eurjchem-1346	83	53	c	c	NOUN
eurjchem-1346	83	54	)	)	PUNCT
eurjchem-1346	83	55	.	.	PUNCT
eurjchem-1346	84	1	1h	1h	NUM
eurjchem-1346	84	2	nmr	nmr	NOUN
eurjchem-1346	84	3	(	(	PUNCT
eurjchem-1346	84	4	300	300	NUM
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eurjchem-1346	84	6	,	,	PUNCT
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eurjchem-1346	84	8	,	,	PUNCT
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eurjchem-1346	84	10	,	,	PUNCT
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eurjchem-1346	84	12	):	):	PUNCT
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eurjchem-1346	84	14	(	(	PUNCT
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eurjchem-1346	84	16	,	,	PUNCT
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eurjchem-1346	84	18	,	,	PUNCT
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eurjchem-1346	84	21	,	,	PUNCT
eurjchem-1346	84	22	7.40	7.40	NUM
eurjchem-1346	84	23	(	(	PUNCT
eurjchem-1346	84	24	d	d	PROPN
eurjchem-1346	84	25	,	,	PUNCT
eurjchem-1346	84	26	j	j	PROPN
eurjchem-1346	84	27	=	=	SYM
eurjchem-1346	84	28	7.4	7.4	NUM
eurjchem-1346	84	29	hz	hz	NOUN
eurjchem-1346	84	30	,	,	PUNCT
eurjchem-1346	84	31	1h	1h	NUM
eurjchem-1346	84	32	,	,	PUNCT
eurjchem-1346	84	33	h‐8ar	h‐8ar	NOUN
eurjchem-1346	84	34	)	)	PUNCT
eurjchem-1346	84	35	,	,	PUNCT
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eurjchem-1346	84	38	t	t	PROPN
eurjchem-1346	84	39	,	,	PUNCT
eurjchem-1346	84	40	1h	1h	NUM
eurjchem-1346	84	41	,	,	PUNCT
eurjchem-1346	84	42	h‐7ar	h‐7ar	NOUN
eurjchem-1346	84	43	)	)	PUNCT
eurjchem-1346	84	44	,	,	PUNCT
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eurjchem-1346	84	46	(	(	PUNCT
eurjchem-1346	84	47	d	d	PROPN
eurjchem-1346	84	48	,	,	PUNCT
eurjchem-1346	84	49	j	j	PROPN
eurjchem-1346	85	1	=	=	SYM
eurjchem-1346	85	2	6.1	6.1	NUM
eurjchem-1346	85	3	hz	hz	NOUN
eurjchem-1346	85	4	,	,	PUNCT
eurjchem-1346	85	5	1h	1h	NUM
eurjchem-1346	85	6	,	,	PUNCT
eurjchem-1346	85	7	h‐6ar	h‐6ar	NOUN
eurjchem-1346	85	8	)	)	PUNCT
eurjchem-1346	85	9	,	,	PUNCT
eurjchem-1346	85	10	11.50	11.50	NUM
eurjchem-1346	85	11	(	(	PUNCT
eurjchem-1346	85	12	s	s	PROPN
eurjchem-1346	85	13	,	,	PUNCT
eurjchem-1346	85	14	1h	1h	NUM
eurjchem-1346	85	15	,	,	PUNCT
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eurjchem-1346	85	17	,	,	PUNCT
eurjchem-1346	85	18	exchanged	exchange	VERB
eurjchem-1346	85	19	with	with	ADP
eurjchem-1346	85	20	d2o	d2o	NOUN
eurjchem-1346	85	21	)	)	PUNCT
eurjchem-1346	85	22	.	.	PUNCT
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eurjchem-1346	86	2	(	(	PUNCT
eurjchem-1346	86	3	ei	ei	PROPN
eurjchem-1346	86	4	,	,	PUNCT
eurjchem-1346	86	5	m	m	PROPN
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eurjchem-1346	86	7	z	z	PROPN
eurjchem-1346	86	8	(	(	PUNCT
eurjchem-1346	86	9	%	%	NOUN
eurjchem-1346	86	10	)	)	PUNCT
eurjchem-1346	86	11	):	):	PUNCT
eurjchem-1346	86	12	240	240	NUM
eurjchem-1346	86	13	(	(	PUNCT
eurjchem-1346	86	14	m+	m+	NUM
eurjchem-1346	86	15	,	,	PUNCT
eurjchem-1346	86	16	0.53	0.53	NUM
eurjchem-1346	86	17	)	)	PUNCT
eurjchem-1346	86	18	,	,	PUNCT
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eurjchem-1346	86	20	(	(	PUNCT
eurjchem-1346	86	21	m++2	m++2	PROPN
eurjchem-1346	86	22	,	,	PUNCT
eurjchem-1346	86	23	0.67	0.67	NUM
eurjchem-1346	86	24	)	)	PUNCT
eurjchem-1346	86	25	.	.	PUNCT
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eurjchem-1346	87	4	.	.	PUNCT
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eurjchem-1346	88	3	:	:	PUNCT
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eurjchem-1346	88	5	,	,	PUNCT
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eurjchem-1346	88	8	h	h	NOUN
eurjchem-1346	88	9	,	,	PUNCT
eurjchem-1346	88	10	2.52	2.52	NUM
eurjchem-1346	88	11	;	;	PUNCT
eurjchem-1346	88	12	n	n	CCONJ
eurjchem-1346	88	13	,	,	PUNCT
eurjchem-1346	88	14	17.50	17.50	NUM
eurjchem-1346	88	15	.	.	PUNCT
eurjchem-1346	89	1	found	find	VERB
eurjchem-1346	89	2	:	:	PUNCT
eurjchem-1346	90	1	c	c	X
eurjchem-1346	90	2	,	,	PUNCT
eurjchem-1346	90	3	40.13	40.13	NUM
eurjchem-1346	90	4	;	;	PUNCT
eurjchem-1346	90	5	h	h	NOUN
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eurjchem-1346	90	7	2.47	2.47	NUM
eurjchem-1346	90	8	;	;	PUNCT
eurjchem-1346	90	9	n	n	CCONJ
eurjchem-1346	90	10	,	,	PUNCT
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eurjchem-1346	90	12	%	%	NOUN
eurjchem-1346	90	13	.	.	PUNCT
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eurjchem-1346	91	5	/	/	SYM
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eurjchem-1346	91	14	(	(	PUNCT
eurjchem-1346	91	15	2016	2016	NUM
eurjchem-1346	91	16	)	)	PUNCT
eurjchem-1346	91	17	19‐29	19‐29	PROPN
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eurjchem-1346	91	19	n	n	CCONJ
eurjchem-1346	91	20	n	n	ADP
eurjchem-1346	91	21	h	h	NOUN
eurjchem-1346	91	22	n	n	ADP
eurjchem-1346	91	23	o	o	NOUN
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eurjchem-1346	91	26	nh2	nh2	PROPN
eurjchem-1346	91	27	o	o	PROPN
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eurjchem-1346	92	1	o	o	X
eurjchem-1346	92	2	ch3	ch3	PROPN
eurjchem-1346	92	3	n	n	CCONJ
eurjchem-1346	92	4	n	n	PROPN
eurjchem-1346	92	5	h	h	NOUN
eurjchem-1346	92	6	n	n	ADV
eurjchem-1346	92	7	o	o	NOUN
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eurjchem-1346	92	9	n	n	CCONJ
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eurjchem-1346	92	12	n	n	ADP
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eurjchem-1346	92	14	n	n	CCONJ
eurjchem-1346	92	15	r'r	r'r	VERB
eurjchem-1346	92	16	n	n	CCONJ
eurjchem-1346	92	17	n	n	NOUN
eurjchem-1346	92	18	h	h	NOUN
eurjchem-1346	92	19	n	n	CCONJ
eurjchem-1346	92	20	o	o	NOUN
eurjchem-1346	92	21	h	h	NOUN
eurjchem-1346	93	1	n	n	PROPN
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eurjchem-1346	93	3	n	n	CCONJ
eurjchem-1346	93	4	n	n	NOUN
eurjchem-1346	93	5	h	h	NOUN
eurjchem-1346	93	6	n	n	ADP
eurjchem-1346	93	7	o	o	X
eurjchem-1346	94	1	hn	hn	PROPN
eurjchem-1346	94	2	n	n	PROPN
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eurjchem-1346	94	4	n	n	PROPN
eurjchem-1346	94	5	h	h	NOUN
eurjchem-1346	94	6	n	n	ADP
eurjchem-1346	94	7	o	o	X
eurjchem-1346	94	8	nh	nh	PROPN
eurjchem-1346	94	9	nr	nr	PROPN
eurjchem-1346	94	10	n	n	CCONJ
eurjchem-1346	94	11	n	n	NOUN
eurjchem-1346	94	12	h	h	NOUN
eurjchem-1346	94	13	n	n	CCONJ
eurjchem-1346	94	14	o	o	NOUN
eurjchem-1346	94	15	h	h	NOUN
eurjchem-1346	94	16	n	n	ADP
eurjchem-1346	94	17	r	r	NOUN
eurjchem-1346	94	18	r	r	NOUN
eurjchem-1346	94	19	'	'	PUNCT
eurjchem-1346	94	20	+	+	NUM
eurjchem-1346	94	21	1	1	NUM
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eurjchem-1346	94	23	3a	3a	NUM
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eurjchem-1346	94	27	5a	5a	NUM
eurjchem-1346	94	28	-	-	PUNCT
eurjchem-1346	94	29	e6a	e6a	ADJ
eurjchem-1346	94	30	-	-	PUNCT
eurjchem-1346	94	31	d	d	NOUN
eurjchem-1346	94	32	7a	7a	NUM
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eurjchem-1346	94	34	c	c	NOUN
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eurjchem-1346	94	36	r	r	NOUN
eurjchem-1346	94	37	,	,	PUNCT
eurjchem-1346	94	38	r'=	r'=	PRON
eurjchem-1346	94	39	c2h5	c2h5	ADP
eurjchem-1346	94	40	3b	3b	NUM
eurjchem-1346	94	41	nrr'=	nrr'=	NOUN
eurjchem-1346	94	42	3c	3c	NUM
eurjchem-1346	94	43	nrr'=	nrr'=	NOUN
eurjchem-1346	94	44	3d	3d	PROPN
eurjchem-1346	94	45	r=	r=	ADJ
eurjchem-1346	94	46	h	h	NOUN
eurjchem-1346	94	47	,	,	PUNCT
eurjchem-1346	94	48	r'=	r'=	X
eurjchem-1346	94	49	c6h5	c6h5	PROPN
eurjchem-1346	94	50	3e	3e	X
eurjchem-1346	94	51	r=	r=	PROPN
eurjchem-1346	94	52	h	h	NOUN
eurjchem-1346	94	53	,	,	PUNCT
eurjchem-1346	94	54	r'=	r'=	X
eurjchem-1346	94	55	2	2	NUM
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eurjchem-1346	94	57	ch3c6h4	ch3c6h4	PROPN
eurjchem-1346	94	58	3f	3f	PROPN
eurjchem-1346	94	59	r=	r=	PROPN
eurjchem-1346	94	60	h	h	NOUN
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eurjchem-1346	94	62	r'=	r'=	X
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eurjchem-1346	94	66	3	3	NUM
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eurjchem-1346	94	68	r=	r=	ADJ
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eurjchem-1346	94	71	r'=	r'=	X
eurjchem-1346	94	72	4	4	NUM
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eurjchem-1346	94	74	ch3c6h4	ch3c6h4	PROPN
eurjchem-1346	94	75	3h	3h	NUM
eurjchem-1346	94	76	r=	r=	PROPN
eurjchem-1346	94	77	h	h	NOUN
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eurjchem-1346	94	79	r'=	r'=	X
eurjchem-1346	94	80	4	4	NUM
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eurjchem-1346	94	82	clc6h4	clc6h4	NOUN
eurjchem-1346	94	83	3i	3i	NOUN
eurjchem-1346	94	84	r=	r=	ADJ
eurjchem-1346	94	85	h	h	NOUN
eurjchem-1346	94	86	,	,	PUNCT
eurjchem-1346	94	87	r'=	r'=	X
eurjchem-1346	94	88	4	4	NUM
eurjchem-1346	94	89	-	-	PUNCT
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eurjchem-1346	94	91	3j	3j	PROPN
eurjchem-1346	94	92	r=	r=	PROPN
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eurjchem-1346	94	94	,	,	PUNCT
eurjchem-1346	94	95	r'=	r'=	X
eurjchem-1346	94	96	c6h5	c6h5	VERB
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eurjchem-1346	94	98	n	n	NOUN
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eurjchem-1346	94	100	n	n	ADP
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eurjchem-1346	94	103	n	n	CCONJ
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eurjchem-1346	94	106	n	n	CCONJ
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eurjchem-1346	94	116	r'=	r'=	X
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eurjchem-1346	94	119	r=	r=	ADJ
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eurjchem-1346	94	122	r'=	r'=	X
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eurjchem-1346	94	125	clc6h4	clc6h4	NOUN
eurjchem-1346	94	126	5c	5c	NUM
eurjchem-1346	94	127	r=	r=	ADJ
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eurjchem-1346	94	129	,	,	PUNCT
eurjchem-1346	94	130	r'=	r'=	X
eurjchem-1346	94	131	4	4	NUM
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eurjchem-1346	94	133	no2c6h4	no2c6h4	PRON
eurjchem-1346	94	134	5d	5d	NUM
eurjchem-1346	94	135	r=	r=	ADJ
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eurjchem-1346	94	137	,	,	PUNCT
eurjchem-1346	94	138	r'=	r'=	X
eurjchem-1346	94	139	4	4	NUM
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eurjchem-1346	94	141	ch3oc6h4	ch3oc6h4	ADJ
eurjchem-1346	94	142	5e	5e	NOUN
eurjchem-1346	94	143	r=	r=	PROPN
eurjchem-1346	94	144	ch3	ch3	PROPN
eurjchem-1346	94	145	,	,	PUNCT
eurjchem-1346	94	146	r'=	r'=	X
eurjchem-1346	94	147	c6h5	c6h5	VERB
eurjchem-1346	94	148	6a	6a	NOUN
eurjchem-1346	94	149	r=	r=	ADJ
eurjchem-1346	95	1	c6h5	c6h5	PROPN
eurjchem-1346	95	2	6b	6b	X
eurjchem-1346	95	3	r=	r=	ADJ
eurjchem-1346	95	4	4	4	NUM
eurjchem-1346	95	5	-	-	PUNCT
eurjchem-1346	95	6	clc6h4	clc6h4	PROPN
eurjchem-1346	95	7	6c	6c	NOUN
eurjchem-1346	95	8	r=	r=	ADJ
eurjchem-1346	95	9	4	4	NUM
eurjchem-1346	95	10	-	-	PUNCT
eurjchem-1346	95	11	no2c6h4	no2c6h4	NOUN
eurjchem-1346	95	12	6d	6d	NUM
eurjchem-1346	95	13	r=	r=	ADJ
eurjchem-1346	95	14	4	4	NUM
eurjchem-1346	95	15	-	-	SYM
eurjchem-1346	95	16	ch3oc6h4	ch3oc6h4	NOUN
eurjchem-1346	95	17	(	(	PUNCT
eurjchem-1346	95	18	i	i	NOUN
eurjchem-1346	95	19	)	)	PUNCT
eurjchem-1346	95	20	(	(	PUNCT
eurjchem-1346	95	21	ii	ii	NOUN
eurjchem-1346	95	22	)	)	PUNCT
eurjchem-1346	95	23	(	(	PUNCT
eurjchem-1346	95	24	iii	iii	NOUN
eurjchem-1346	95	25	)	)	PUNCT
eurjchem-1346	95	26	(	(	PUNCT
eurjchem-1346	95	27	iv	iv	X
eurjchem-1346	95	28	)	)	PUNCT
eurjchem-1346	95	29	(	(	PUNCT
eurjchem-1346	95	30	v	v	NOUN
eurjchem-1346	95	31	)	)	PUNCT
eurjchem-1346	95	32	(	(	PUNCT
eurjchem-1346	95	33	vi	vi	NOUN
eurjchem-1346	95	34	)	)	PUNCT
eurjchem-1346	95	35	(	(	PUNCT
eurjchem-1346	95	36	vii	vii	PROPN
eurjchem-1346	95	37	)	)	PUNCT
eurjchem-1346	95	38	reagents	reagent	NOUN
eurjchem-1346	95	39	and	and	CCONJ
eurjchem-1346	95	40	conditions	condition	NOUN
eurjchem-1346	95	41	:	:	PUNCT
eurjchem-1346	95	42	(	(	PUNCT
eurjchem-1346	95	43	i	i	NOUN
eurjchem-1346	95	44	)	)	PUNCT
eurjchem-1346	95	45	ethanol	ethanol	NOUN
eurjchem-1346	95	46	,	,	PUNCT
eurjchem-1346	95	47	reflux	reflux	NOUN
eurjchem-1346	95	48	,	,	PUNCT
eurjchem-1346	95	49	10	10	NUM
eurjchem-1346	95	50	h.	h.	PROPN
eurjchem-1346	95	51	(	(	PUNCT
eurjchem-1346	95	52	ii	ii	NOUN
eurjchem-1346	95	53	)	)	PUNCT
eurjchem-1346	95	54	bromine	bromine	NOUN
eurjchem-1346	95	55	,	,	PUNCT
eurjchem-1346	95	56	glacial	glacial	ADJ
eurjchem-1346	95	57	acetic	acetic	ADJ
eurjchem-1346	95	58	acid	acid	NOUN
eurjchem-1346	95	59	,	,	PUNCT
eurjchem-1346	95	60	anhydrous	anhydrous	ADJ
eurjchem-1346	95	61	sodium	sodium	NOUN
eurjchem-1346	95	62	acetate	acetate	NOUN
eurjchem-1346	95	63	,	,	PUNCT
eurjchem-1346	95	64	reflux	reflux	NOUN
eurjchem-1346	95	65	,	,	PUNCT
eurjchem-1346	95	66	30	30	NUM
eurjchem-1346	95	67	min	min	NOUN
eurjchem-1346	95	68	.	.	PROPN
eurjchem-1346	95	69	(	(	PUNCT
eurjchem-1346	95	70	iii	iii	NOUN
eurjchem-1346	95	71	)	)	PUNCT
eurjchem-1346	95	72	appropriate	appropriate	ADJ
eurjchem-1346	95	73	amine	amine	NOUN
eurjchem-1346	95	74	,	,	PUNCT
eurjchem-1346	95	75	ethanol	ethanol	NOUN
eurjchem-1346	95	76	,	,	PUNCT
eurjchem-1346	95	77	sodium	sodium	NOUN
eurjchem-1346	95	78	iodide	iodide	NOUN
eurjchem-1346	95	79	,	,	PUNCT
eurjchem-1346	95	80	reflux	reflux	NOUN
eurjchem-1346	95	81	,	,	PUNCT
eurjchem-1346	95	82	10	10	NUM
eurjchem-1346	95	83	h.	h.	PROPN
eurjchem-1346	95	84	(	(	PUNCT
eurjchem-1346	95	85	iv	iv	X
eurjchem-1346	95	86	)	)	PUNCT
eurjchem-1346	95	87	hydrazine	hydrazine	NOUN
eurjchem-1346	95	88	hydrate	hydrate	NOUN
eurjchem-1346	95	89	,	,	PUNCT
eurjchem-1346	95	90	ethanol	ethanol	NOUN
eurjchem-1346	95	91	,	,	PUNCT
eurjchem-1346	95	92	reflux	reflux	NOUN
eurjchem-1346	95	93	,	,	PUNCT
eurjchem-1346	95	94	9	9	NUM
eurjchem-1346	95	95	h.	h.	NOUN
eurjchem-1346	95	96	(	(	PUNCT
eurjchem-1346	95	97	v	v	NOUN
eurjchem-1346	95	98	)	)	PUNCT
eurjchem-1346	95	99	appropriate	appropriate	ADJ
eurjchem-1346	95	100	aldehyde	aldehyde	NOUN
eurjchem-1346	95	101	or	or	CCONJ
eurjchem-1346	95	102	ketone	ketone	NOUN
eurjchem-1346	95	103	,	,	PUNCT
eurjchem-1346	95	104	glacial	glacial	ADJ
eurjchem-1346	95	105	acetic	acetic	ADJ
eurjchem-1346	95	106	acid	acid	NOUN
eurjchem-1346	95	107	,	,	PUNCT
eurjchem-1346	95	108	reflux	reflux	NOUN
eurjchem-1346	95	109	,	,	PUNCT
eurjchem-1346	95	110	8	8	NUM
eurjchem-1346	95	111	h.	h.	NOUN
eurjchem-1346	95	112	(	(	PUNCT
eurjchem-1346	95	113	vi	vi	NOUN
eurjchem-1346	95	114	)	)	PUNCT
eurjchem-1346	95	115	bromine	bromine	NOUN
eurjchem-1346	95	116	,	,	PUNCT
eurjchem-1346	95	117	glacial	glacial	ADJ
eurjchem-1346	95	118	acetic	acetic	ADJ
eurjchem-1346	95	119	acid	acid	NOUN
eurjchem-1346	95	120	,	,	PUNCT
eurjchem-1346	95	121	sodium	sodium	NOUN
eurjchem-1346	95	122	acetate	acetate	NOUN
eurjchem-1346	95	123	,	,	PUNCT
eurjchem-1346	95	124	room	room	NOUN
eurjchem-1346	95	125	temp	temp	NOUN
eurjchem-1346	95	126	.	.	PUNCT
eurjchem-1346	96	1	,	,	PUNCT
eurjchem-1346	96	2	3	3	NUM
eurjchem-1346	96	3	h.	h.	NOUN
eurjchem-1346	96	4	(	(	PUNCT
eurjchem-1346	96	5	vii	vii	PROPN
eurjchem-1346	96	6	)	)	PUNCT
eurjchem-1346	96	7	appropriate	appropriate	ADJ
eurjchem-1346	96	8	cyclic	cyclic	ADJ
eurjchem-1346	96	9	acid	acid	NOUN
eurjchem-1346	96	10	anhydride	anhydride	NOUN
eurjchem-1346	96	11	,	,	PUNCT
eurjchem-1346	96	12	glacial	glacial	ADJ
eurjchem-1346	96	13	acetic	acetic	ADJ
eurjchem-1346	96	14	acid	acid	NOUN
eurjchem-1346	96	15	,	,	PUNCT
eurjchem-1346	96	16	reflux	reflux	NOUN
eurjchem-1346	96	17	,	,	PUNCT
eurjchem-1346	96	18	6	6	NUM
eurjchem-1346	96	19	h.	h.	NOUN
eurjchem-1346	96	20	scheme	scheme	NOUN
eurjchem-1346	96	21	1	1	NUM
eurjchem-1346	96	22	2.1.3	2.1.3	NUM
eurjchem-1346	96	23	.	.	PUNCT
eurjchem-1346	96	24	general	general	ADJ
eurjchem-1346	96	25	procedure	procedure	NOUN
eurjchem-1346	96	26	for	for	ADP
eurjchem-1346	96	27	synthesis	synthesis	NOUN
eurjchem-1346	96	28	of	of	ADP
eurjchem-1346	97	1	3‐substituted	3‐substitute	VERB
eurjchem-1346	97	2	methylpyrido[2,3‐b]pyrazin‐2(1h)ones	methylpyrido[2,3‐b]pyrazin‐2(1h)ones	PROPN
eurjchem-1346	97	3	(	(	PUNCT
eurjchem-1346	97	4	3a‐j	3a‐j	NOUN
eurjchem-1346	97	5	)	)	PUNCT
eurjchem-1346	97	6	appropriate	appropriate	ADJ
eurjchem-1346	97	7	amine	amine	NOUN
eurjchem-1346	97	8	(	(	PUNCT
eurjchem-1346	97	9	0.02	0.02	NUM
eurjchem-1346	97	10	mol	mol	NOUN
eurjchem-1346	97	11	)	)	PUNCT
eurjchem-1346	97	12	was	be	AUX
eurjchem-1346	97	13	added	add	VERB
eurjchem-1346	97	14	to	to	ADP
eurjchem-1346	97	15	a	a	DET
eurjchem-1346	97	16	solution	solution	NOUN
eurjchem-1346	97	17	of	of	ADP
eurjchem-1346	97	18	compound	compound	NOUN
eurjchem-1346	97	19	2	2	NUM
eurjchem-1346	97	20	(	(	PUNCT
eurjchem-1346	97	21	2.4	2.4	NUM
eurjchem-1346	97	22	g	g	NOUN
eurjchem-1346	97	23	,	,	PUNCT
eurjchem-1346	97	24	0.01	0.01	NUM
eurjchem-1346	97	25	mol	mol	NOUN
eurjchem-1346	97	26	)	)	PUNCT
eurjchem-1346	97	27	in	in	ADP
eurjchem-1346	97	28	ethanol	ethanol	NOUN
eurjchem-1346	97	29	(	(	PUNCT
eurjchem-1346	97	30	30	30	NUM
eurjchem-1346	97	31	ml	ml	NOUN
eurjchem-1346	97	32	)	)	PUNCT
eurjchem-1346	97	33	containing	contain	VERB
eurjchem-1346	97	34	sodium	sodium	NOUN
eurjchem-1346	97	35	iodide	iodide	NOUN
eurjchem-1346	97	36	(	(	PUNCT
eurjchem-1346	97	37	0.15	0.15	NUM
eurjchem-1346	97	38	g	g	NOUN
eurjchem-1346	97	39	,	,	PUNCT
eurjchem-1346	97	40	0.001	0.001	NUM
eurjchem-1346	97	41	mol	mol	NOUN
eurjchem-1346	97	42	)	)	PUNCT
eurjchem-1346	97	43	and	and	CCONJ
eurjchem-1346	97	44	refluxed	refluxe	VERB
eurjchem-1346	97	45	for	for	ADP
eurjchem-1346	97	46	10	10	NUM
eurjchem-1346	97	47	h.	h.	NOUN
eurjchem-1346	97	48	the	the	DET
eurjchem-1346	97	49	reaction	reaction	NOUN
eurjchem-1346	97	50	mixture	mixture	NOUN
eurjchem-1346	97	51	was	be	AUX
eurjchem-1346	97	52	cooled	cool	VERB
eurjchem-1346	97	53	,	,	PUNCT
eurjchem-1346	97	54	formed	form	VERB
eurjchem-1346	97	55	precipitate	precipitate	NOUN
eurjchem-1346	97	56	filtered	filter	VERB
eurjchem-1346	97	57	,	,	PUNCT
eurjchem-1346	97	58	washed	wash	VERB
eurjchem-1346	97	59	with	with	ADP
eurjchem-1346	97	60	ethanol	ethanol	NOUN
eurjchem-1346	97	61	(	(	PUNCT
eurjchem-1346	97	62	5	5	NUM
eurjchem-1346	97	63	ml	ml	NOUN
eurjchem-1346	97	64	)	)	PUNCT
eurjchem-1346	97	65	and	and	CCONJ
eurjchem-1346	97	66	dried	dry	VERB
eurjchem-1346	97	67	.	.	PUNCT
eurjchem-1346	98	1	the	the	DET
eurjchem-1346	98	2	crude	crude	ADJ
eurjchem-1346	98	3	product	product	NOUN
eurjchem-1346	98	4	was	be	AUX
eurjchem-1346	98	5	crystalized	crystalize	VERB
eurjchem-1346	98	6	from	from	ADP
eurjchem-1346	98	7	ethanol	ethanol	NOUN
eurjchem-1346	98	8	(	(	PUNCT
eurjchem-1346	98	9	scheme	scheme	NOUN
eurjchem-1346	98	10	1	1	NUM
eurjchem-1346	98	11	)	)	PUNCT
eurjchem-1346	98	12	.	.	PUNCT
eurjchem-1346	99	1	3‐(n	3‐(n	NOUN
eurjchem-1346	99	2	,	,	PUNCT
eurjchem-1346	99	3	n‐diethylamino)methylpyrido[2,3‐b]pyrazin‐2(1h)one	n‐diethylamino)methylpyrido[2,3‐b]pyrazin‐2(1h)one	NOUN
eurjchem-1346	99	4	(	(	PUNCT
eurjchem-1346	99	5	3a	3a	NUM
eurjchem-1346	99	6	):	):	PUNCT
eurjchem-1346	99	7	yield	yield	NOUN
eurjchem-1346	99	8	:	:	PUNCT
eurjchem-1346	99	9	81	81	NUM
eurjchem-1346	99	10	%	%	NOUN
eurjchem-1346	99	11	.	.	PUNCT
eurjchem-1346	100	1	m.p	m.p	PROPN
eurjchem-1346	100	2	.	.	PROPN
eurjchem-1346	100	3	:	:	PUNCT
eurjchem-1346	101	1	262‐263	262‐263	NUM
eurjchem-1346	101	2	°	°	ADP
eurjchem-1346	101	3	c	c	NOUN
eurjchem-1346	101	4	.	.	PUNCT
eurjchem-1346	102	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	102	2	(	(	PUNCT
eurjchem-1346	102	3	kbr	kbr	PROPN
eurjchem-1346	102	4	,	,	PUNCT
eurjchem-1346	102	5			PROPN
eurjchem-1346	102	6	,	,	PUNCT
eurjchem-1346	102	7	cm‐1	cm‐1	PROPN
eurjchem-1346	102	8	):	):	PUNCT
eurjchem-1346	102	9	3238	3238	NUM
eurjchem-1346	102	10	(	(	PUNCT
eurjchem-1346	102	11	nh	nh	NOUN
eurjchem-1346	102	12	)	)	PUNCT
eurjchem-1346	102	13	,	,	PUNCT
eurjchem-1346	102	14	3051	3051	NUM
eurjchem-1346	102	15	(	(	PUNCT
eurjchem-1346	102	16	ch	ch	PROPN
eurjchem-1346	102	17	ar	ar	PROPN
eurjchem-1346	102	18	)	)	PUNCT
eurjchem-1346	102	19	,	,	PUNCT
eurjchem-1346	102	20	2924	2924	NUM
eurjchem-1346	102	21	,	,	PUNCT
eurjchem-1346	102	22	2852	2852	NUM
eurjchem-1346	102	23	(	(	PUNCT
eurjchem-1346	102	24	ch	ch	NOUN
eurjchem-1346	102	25	aliph	aliph	PROPN
eurjchem-1346	102	26	)	)	PUNCT
eurjchem-1346	102	27	,	,	PUNCT
eurjchem-1346	102	28	1672	1672	NUM
eurjchem-1346	102	29	(	(	PUNCT
eurjchem-1346	102	30	c	c	NOUN
eurjchem-1346	102	31	=	=	NOUN
eurjchem-1346	102	32	o	o	NOUN
eurjchem-1346	102	33	)	)	PUNCT
eurjchem-1346	102	34	,	,	PUNCT
eurjchem-1346	102	35	1637	1637	NUM
eurjchem-1346	102	36	,	,	PUNCT
eurjchem-1346	102	37	1624	1624	NUM
eurjchem-1346	102	38	,	,	PUNCT
eurjchem-1346	102	39	1612	1612	NUM
eurjchem-1346	102	40	,	,	PUNCT
eurjchem-1346	102	41	1593	1593	NUM
eurjchem-1346	102	42	,	,	PUNCT
eurjchem-1346	102	43	1508	1508	NUM
eurjchem-1346	102	44	(	(	PUNCT
eurjchem-1346	102	45	c	c	NOUN
eurjchem-1346	102	46	=	=	SYM
eurjchem-1346	102	47	n	n	X
eurjchem-1346	102	48	,	,	PUNCT
eurjchem-1346	102	49	nh	nh	PROPN
eurjchem-1346	102	50	,	,	PUNCT
eurjchem-1346	102	51	c	c	X
eurjchem-1346	102	52	=	=	SYM
eurjchem-1346	102	53	c	c	NOUN
eurjchem-1346	102	54	)	)	PUNCT
eurjchem-1346	102	55	.	.	PUNCT
eurjchem-1346	103	1	1h	1h	NUM
eurjchem-1346	103	2	nmr	nmr	NOUN
eurjchem-1346	103	3	(	(	PUNCT
eurjchem-1346	103	4	300	300	NUM
eurjchem-1346	103	5	mhz	mhz	NOUN
eurjchem-1346	103	6	,	,	PUNCT
eurjchem-1346	103	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	103	8	,	,	PUNCT
eurjchem-1346	103	9	δ	δ	PROPN
eurjchem-1346	103	10	,	,	PUNCT
eurjchem-1346	103	11	ppm	ppm	NUM
eurjchem-1346	103	12	):	):	PUNCT
eurjchem-1346	103	13	1.41	1.41	NUM
eurjchem-1346	103	14	(	(	PUNCT
eurjchem-1346	103	15	t	t	PROPN
eurjchem-1346	103	16	,	,	PUNCT
eurjchem-1346	103	17	6h	6h	NUM
eurjchem-1346	103	18	,	,	PUNCT
eurjchem-1346	103	19	2xch2ch3	2xch2ch3	NOUN
eurjchem-1346	103	20	)	)	PUNCT
eurjchem-1346	103	21	,	,	PUNCT
eurjchem-1346	103	22	2.29	2.29	NUM
eurjchem-1346	103	23	(	(	PUNCT
eurjchem-1346	103	24	q	q	NOUN
eurjchem-1346	103	25	,	,	PUNCT
eurjchem-1346	103	26	4h	4h	NUM
eurjchem-1346	103	27	,	,	PUNCT
eurjchem-1346	103	28	2x	2x	NUM
eurjchem-1346	103	29	ch2ch3	ch2ch3	ADJ
eurjchem-1346	103	30	)	)	PUNCT
eurjchem-1346	103	31	,	,	PUNCT
eurjchem-1346	103	32	2.43	2.43	NUM
eurjchem-1346	103	33	(	(	PUNCT
eurjchem-1346	103	34	s	s	PROPN
eurjchem-1346	103	35	,	,	PUNCT
eurjchem-1346	103	36	2h	2h	NUM
eurjchem-1346	103	37	,	,	PUNCT
eurjchem-1346	103	38	ch2	ch2	PROPN
eurjchem-1346	103	39	)	)	PUNCT
eurjchem-1346	103	40	,	,	PUNCT
eurjchem-1346	103	41	7.11	7.11	NUM
eurjchem-1346	103	42	(	(	PUNCT
eurjchem-1346	103	43	d	d	PROPN
eurjchem-1346	103	44	,	,	PUNCT
eurjchem-1346	103	45	j	j	PROPN
eurjchem-1346	103	46	=	=	SYM
eurjchem-1346	103	47	7.4	7.4	NUM
eurjchem-1346	103	48	hz	hz	NOUN
eurjchem-1346	103	49	,	,	PUNCT
eurjchem-1346	103	50	1h	1h	NUM
eurjchem-1346	103	51	,	,	PUNCT
eurjchem-1346	103	52	h‐8ar	h‐8ar	NOUN
eurjchem-1346	103	53	)	)	PUNCT
eurjchem-1346	103	54	,	,	PUNCT
eurjchem-1346	103	55	7.30	7.30	NUM
eurjchem-1346	103	56	(	(	PUNCT
eurjchem-1346	103	57	t	t	PROPN
eurjchem-1346	103	58	,	,	PUNCT
eurjchem-1346	103	59	1h	1h	NUM
eurjchem-1346	103	60	,	,	PUNCT
eurjchem-1346	103	61	h‐7ar	h‐7ar	NOUN
eurjchem-1346	103	62	)	)	PUNCT
eurjchem-1346	103	63	,	,	PUNCT
eurjchem-1346	103	64	8.21	8.21	NUM
eurjchem-1346	103	65	(	(	PUNCT
eurjchem-1346	103	66	d	d	PROPN
eurjchem-1346	103	67	,	,	PUNCT
eurjchem-1346	103	68	j	j	PROPN
eurjchem-1346	103	69	=	=	SYM
eurjchem-1346	103	70	6.4	6.4	NUM
eurjchem-1346	103	71	hz	hz	NOUN
eurjchem-1346	103	72	,	,	PUNCT
eurjchem-1346	103	73	1h	1h	NUM
eurjchem-1346	103	74	,	,	PUNCT
eurjchem-1346	103	75	h‐6ar	h‐6ar	NOUN
eurjchem-1346	103	76	)	)	PUNCT
eurjchem-1346	103	77	,	,	PUNCT
eurjchem-1346	103	78	10.80	10.80	NUM
eurjchem-1346	103	79	(	(	PUNCT
eurjchem-1346	103	80	s	s	PROPN
eurjchem-1346	103	81	,	,	PUNCT
eurjchem-1346	103	82	1h	1h	NUM
eurjchem-1346	103	83	,	,	PUNCT
eurjchem-1346	103	84	nh	nh	PROPN
eurjchem-1346	103	85	,	,	PUNCT
eurjchem-1346	103	86	exchanged	exchange	VERB
eurjchem-1346	103	87	with	with	ADP
eurjchem-1346	103	88	d2o	d2o	NOUN
eurjchem-1346	103	89	)	)	PUNCT
eurjchem-1346	103	90	.	.	PUNCT
eurjchem-1346	104	1	anal	anal	PROPN
eurjchem-1346	104	2	.	.	PUNCT
eurjchem-1346	104	3	calcd	calcd	NOUN
eurjchem-1346	104	4	.	.	PUNCT
eurjchem-1346	105	1	for	for	SCONJ
eurjchem-1346	105	2	c12h16n4o	c12h16n4o	NOUN
eurjchem-1346	105	3	:	:	PUNCT
eurjchem-1346	105	4	c	c	X
eurjchem-1346	105	5	,	,	PUNCT
eurjchem-1346	105	6	62.05	62.05	NUM
eurjchem-1346	105	7	;	;	PUNCT
eurjchem-1346	105	8	h	h	NOUN
eurjchem-1346	105	9	,	,	PUNCT
eurjchem-1346	105	10	6.94	6.94	NUM
eurjchem-1346	105	11	;	;	PUNCT
eurjchem-1346	105	12	n	n	CCONJ
eurjchem-1346	105	13	,	,	PUNCT
eurjchem-1346	105	14	24.12	24.12	NUM
eurjchem-1346	105	15	.	.	PUNCT
eurjchem-1346	105	16	found	find	VERB
eurjchem-1346	105	17	:	:	PUNCT
eurjchem-1346	106	1	c	c	X
eurjchem-1346	106	2	,	,	PUNCT
eurjchem-1346	106	3	62.18	62.18	NUM
eurjchem-1346	106	4	;	;	PUNCT
eurjchem-1346	106	5	h	h	X
eurjchem-1346	106	6	,	,	PUNCT
eurjchem-1346	106	7	6.97	6.97	NUM
eurjchem-1346	106	8	;	;	PUNCT
eurjchem-1346	106	9	n	n	CCONJ
eurjchem-1346	106	10	,	,	PUNCT
eurjchem-1346	106	11	24.13	24.13	NUM
eurjchem-1346	106	12	%	%	NOUN
eurjchem-1346	106	13	.	.	PUNCT
eurjchem-1346	107	1	3‐(piperidin‐1‐yl)methylpyrido[2,3‐b]pyrazin‐2(1h)one	3‐(piperidin‐1‐yl)methylpyrido[2,3‐b]pyrazin‐2(1h)one	NOUN
eurjchem-1346	107	2	(	(	PUNCT
eurjchem-1346	107	3	3b	3b	NUM
eurjchem-1346	107	4	):	):	PUNCT
eurjchem-1346	107	5	yield	yield	NOUN
eurjchem-1346	107	6	:	:	PUNCT
eurjchem-1346	107	7	80	80	NUM
eurjchem-1346	107	8	%	%	NOUN
eurjchem-1346	107	9	.	.	PUNCT
eurjchem-1346	108	1	m.p	m.p	PROPN
eurjchem-1346	108	2	.	.	PROPN
eurjchem-1346	108	3	:	:	PUNCT
eurjchem-1346	109	1	277‐279	277‐279	NUM
eurjchem-1346	109	2	°	°	PROPN
eurjchem-1346	109	3	c	c	PROPN
eurjchem-1346	109	4	.	.	PUNCT
eurjchem-1346	110	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	110	2	(	(	PUNCT
eurjchem-1346	110	3	kbr	kbr	PROPN
eurjchem-1346	110	4	,	,	PUNCT
eurjchem-1346	110	5			PROPN
eurjchem-1346	110	6	,	,	PUNCT
eurjchem-1346	110	7	cm‐1	cm‐1	PROPN
eurjchem-1346	110	8	):	):	PUNCT
eurjchem-1346	110	9	3387	3387	NUM
eurjchem-1346	110	10	(	(	PUNCT
eurjchem-1346	110	11	nh	nh	NOUN
eurjchem-1346	110	12	)	)	PUNCT
eurjchem-1346	110	13	,	,	PUNCT
eurjchem-1346	110	14	3066	3066	NUM
eurjchem-1346	110	15	(	(	PUNCT
eurjchem-1346	110	16	ch	ch	PROPN
eurjchem-1346	110	17	ar	ar	PROPN
eurjchem-1346	110	18	)	)	PUNCT
eurjchem-1346	110	19	,	,	PUNCT
eurjchem-1346	110	20	2964	2964	NUM
eurjchem-1346	110	21	,	,	PUNCT
eurjchem-1346	110	22	2866	2866	NUM
eurjchem-1346	110	23	(	(	PUNCT
eurjchem-1346	110	24	ch	ch	NOUN
eurjchem-1346	110	25	aliph	aliph	PROPN
eurjchem-1346	110	26	)	)	PUNCT
eurjchem-1346	110	27	,	,	PUNCT
eurjchem-1346	110	28	1700	1700	NUM
eurjchem-1346	110	29	(	(	PUNCT
eurjchem-1346	110	30	c	c	NOUN
eurjchem-1346	110	31	=	=	NOUN
eurjchem-1346	110	32	o	o	NOUN
eurjchem-1346	110	33	)	)	PUNCT
eurjchem-1346	110	34	,	,	PUNCT
eurjchem-1346	110	35	1649	1649	NUM
eurjchem-1346	110	36	,	,	PUNCT
eurjchem-1346	110	37	1612	1612	NUM
eurjchem-1346	110	38	,	,	PUNCT
eurjchem-1346	110	39	1591	1591	NUM
eurjchem-1346	110	40	,	,	PUNCT
eurjchem-1346	110	41	1508	1508	NUM
eurjchem-1346	110	42	,	,	PUNCT
eurjchem-1346	110	43	1500	1500	NUM
eurjchem-1346	110	44	(	(	PUNCT
eurjchem-1346	110	45	c	c	NOUN
eurjchem-1346	110	46	=	=	SYM
eurjchem-1346	110	47	n	n	X
eurjchem-1346	110	48	,	,	PUNCT
eurjchem-1346	110	49	nh	nh	PROPN
eurjchem-1346	110	50	,	,	PUNCT
eurjchem-1346	110	51	c	c	X
eurjchem-1346	110	52	=	=	SYM
eurjchem-1346	110	53	c	c	NOUN
eurjchem-1346	110	54	)	)	PUNCT
eurjchem-1346	110	55	.	.	PUNCT
eurjchem-1346	111	1	1h	1h	NUM
eurjchem-1346	111	2	nmr	nmr	NOUN
eurjchem-1346	111	3	(	(	PUNCT
eurjchem-1346	111	4	300	300	NUM
eurjchem-1346	111	5	mhz	mhz	NOUN
eurjchem-1346	111	6	,	,	PUNCT
eurjchem-1346	111	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	111	8	,	,	PUNCT
eurjchem-1346	111	9	δ	δ	PROPN
eurjchem-1346	111	10	,	,	PUNCT
eurjchem-1346	111	11	ppm	ppm	NUM
eurjchem-1346	111	12	):	):	PUNCT
eurjchem-1346	111	13	2.06‐2.32	2.06‐2.32	NUM
eurjchem-1346	111	14	(	(	PUNCT
eurjchem-1346	111	15	m	m	PROPN
eurjchem-1346	111	16	,	,	PUNCT
eurjchem-1346	111	17	10h	10h	NUM
eurjchem-1346	111	18	,	,	PUNCT
eurjchem-1346	111	19	piperidine	piperidine	NOUN
eurjchem-1346	111	20	h	h	NOUN
eurjchem-1346	111	21	)	)	PUNCT
eurjchem-1346	111	22	,	,	PUNCT
eurjchem-1346	111	23	2.51	2.51	NUM
eurjchem-1346	111	24	(	(	PUNCT
eurjchem-1346	111	25	s	s	PROPN
eurjchem-1346	111	26	,	,	PUNCT
eurjchem-1346	111	27	2h	2h	NUM
eurjchem-1346	111	28	,	,	PUNCT
eurjchem-1346	111	29	ch2	ch2	PROPN
eurjchem-1346	111	30	)	)	PUNCT
eurjchem-1346	111	31	,	,	PUNCT
eurjchem-1346	111	32	7.31	7.31	NUM
eurjchem-1346	111	33	(	(	PUNCT
eurjchem-1346	111	34	d	d	NOUN
eurjchem-1346	111	35	,	,	PUNCT
eurjchem-1346	111	36	j	j	PROPN
eurjchem-1346	111	37	=	=	SYM
eurjchem-1346	111	38	8.0	8.0	NUM
eurjchem-1346	111	39	hz	hz	NOUN
eurjchem-1346	111	40	,	,	PUNCT
eurjchem-1346	111	41	1h	1h	NUM
eurjchem-1346	111	42	,	,	PUNCT
eurjchem-1346	111	43	h‐8ar	h‐8ar	NOUN
eurjchem-1346	111	44	)	)	PUNCT
eurjchem-1346	111	45	,	,	PUNCT
eurjchem-1346	111	46	7.53	7.53	NUM
eurjchem-1346	111	47	(	(	PUNCT
eurjchem-1346	111	48	t	t	PROPN
eurjchem-1346	111	49	,	,	PUNCT
eurjchem-1346	111	50	1h	1h	NUM
eurjchem-1346	111	51	,	,	PUNCT
eurjchem-1346	111	52	h‐7ar	h‐7ar	NOUN
eurjchem-1346	111	53	)	)	PUNCT
eurjchem-1346	111	54	,	,	PUNCT
eurjchem-1346	111	55	8.22	8.22	NUM
eurjchem-1346	111	56	(	(	PUNCT
eurjchem-1346	111	57	d	d	PROPN
eurjchem-1346	111	58	,	,	PUNCT
eurjchem-1346	111	59	j	j	PROPN
eurjchem-1346	111	60	=	=	PROPN
eurjchem-1346	111	61	6.6	6.6	NUM
eurjchem-1346	111	62	hz	hz	NOUN
eurjchem-1346	111	63	,	,	PUNCT
eurjchem-1346	111	64	1h	1h	NUM
eurjchem-1346	111	65	,	,	PUNCT
eurjchem-1346	111	66	h‐6ar	h‐6ar	NOUN
eurjchem-1346	111	67	)	)	PUNCT
eurjchem-1346	111	68	,	,	PUNCT
eurjchem-1346	111	69	11.13	11.13	NUM
eurjchem-1346	111	70	(	(	PUNCT
eurjchem-1346	111	71	s	s	PROPN
eurjchem-1346	111	72	,	,	PUNCT
eurjchem-1346	111	73	1h	1h	NUM
eurjchem-1346	111	74	,	,	PUNCT
eurjchem-1346	111	75	nh	nh	PROPN
eurjchem-1346	111	76	,	,	PUNCT
eurjchem-1346	111	77	exchanged	exchange	VERB
eurjchem-1346	111	78	with	with	ADP
eurjchem-1346	111	79	d2o	d2o	NOUN
eurjchem-1346	111	80	)	)	PUNCT
eurjchem-1346	111	81	.	.	PUNCT
eurjchem-1346	112	1	anal	anal	PROPN
eurjchem-1346	112	2	.	.	PUNCT
eurjchem-1346	112	3	calcd	calcd	NOUN
eurjchem-1346	112	4	.	.	PUNCT
eurjchem-1346	113	1	for	for	ADP
eurjchem-1346	113	2	c13h16n4o	c13h16n4o	NOUN
eurjchem-1346	113	3	:	:	PUNCT
eurjchem-1346	113	4	c	c	X
eurjchem-1346	113	5	,	,	PUNCT
eurjchem-1346	113	6	63.91	63.91	NUM
eurjchem-1346	113	7	;	;	PUNCT
eurjchem-1346	113	8	h	h	NOUN
eurjchem-1346	113	9	,	,	PUNCT
eurjchem-1346	113	10	6.60	6.60	NUM
eurjchem-1346	113	11	;	;	PUNCT
eurjchem-1346	113	12	n	n	CCONJ
eurjchem-1346	113	13	,	,	PUNCT
eurjchem-1346	113	14	22.93	22.93	NUM
eurjchem-1346	113	15	.	.	PUNCT
eurjchem-1346	113	16	found	find	VERB
eurjchem-1346	113	17	:	:	PUNCT
eurjchem-1346	114	1	c	c	X
eurjchem-1346	114	2	,	,	PUNCT
eurjchem-1346	114	3	63.98	63.98	NUM
eurjchem-1346	114	4	;	;	PUNCT
eurjchem-1346	114	5	h	h	X
eurjchem-1346	114	6	,	,	PUNCT
eurjchem-1346	114	7	6.64	6.64	NUM
eurjchem-1346	114	8	;	;	PUNCT
eurjchem-1346	114	9	n	n	CCONJ
eurjchem-1346	114	10	,	,	PUNCT
eurjchem-1346	114	11	23.10	23.10	NUM
eurjchem-1346	114	12	%	%	NOUN
eurjchem-1346	114	13	.	.	PUNCT
eurjchem-1346	115	1	3‐(morpholin‐4‐yl)methylpyrido[2,3‐b]pyrazin‐2(1h)one	3‐(morpholin‐4‐yl)methylpyrido[2,3‐b]pyrazin‐2(1h)one	NOUN
eurjchem-1346	115	2	(	(	PUNCT
eurjchem-1346	115	3	3c	3c	NUM
eurjchem-1346	115	4	):	):	PUNCT
eurjchem-1346	115	5	yield	yield	NOUN
eurjchem-1346	115	6	:	:	PUNCT
eurjchem-1346	115	7	74	74	NUM
eurjchem-1346	115	8	%	%	NOUN
eurjchem-1346	115	9	.	.	PUNCT
eurjchem-1346	116	1	m.p	m.p	PROPN
eurjchem-1346	116	2	.	.	PROPN
eurjchem-1346	116	3	:	:	PUNCT
eurjchem-1346	117	1	234‐235	234‐235	NUM
eurjchem-1346	117	2	°	°	SYM
eurjchem-1346	117	3	c	c	X
eurjchem-1346	117	4	.	.	PUNCT
eurjchem-1346	117	5	ft‐ir	ft‐ir	NOUN
eurjchem-1346	117	6	(	(	PUNCT
eurjchem-1346	117	7	kbr	kbr	PROPN
eurjchem-1346	117	8	,	,	PUNCT
eurjchem-1346	117	9			PROPN
eurjchem-1346	117	10	,	,	PUNCT
eurjchem-1346	117	11	cm‐1	cm‐1	PROPN
eurjchem-1346	117	12	):	):	PUNCT
eurjchem-1346	117	13	3394	3394	NUM
eurjchem-1346	117	14	(	(	PUNCT
eurjchem-1346	117	15	nh	nh	NOUN
eurjchem-1346	117	16	)	)	PUNCT
eurjchem-1346	117	17	,	,	PUNCT
eurjchem-1346	117	18	3059	3059	NUM
eurjchem-1346	117	19	(	(	PUNCT
eurjchem-1346	117	20	ch	ch	PROPN
eurjchem-1346	117	21	ar	ar	PROPN
eurjchem-1346	117	22	)	)	PUNCT
eurjchem-1346	117	23	,	,	PUNCT
eurjchem-1346	117	24	2920	2920	NUM
eurjchem-1346	117	25	,	,	PUNCT
eurjchem-1346	117	26	2840	2840	NUM
eurjchem-1346	117	27	(	(	PUNCT
eurjchem-1346	117	28	ch	ch	NOUN
eurjchem-1346	117	29	aliph	aliph	PROPN
eurjchem-1346	117	30	)	)	PUNCT
eurjchem-1346	117	31	,	,	PUNCT
eurjchem-1346	117	32	1674	1674	NUM
eurjchem-1346	117	33	(	(	PUNCT
eurjchem-1346	117	34	c	c	NOUN
eurjchem-1346	117	35	=	=	NOUN
eurjchem-1346	117	36	o	o	NOUN
eurjchem-1346	117	37	)	)	PUNCT
eurjchem-1346	117	38	,	,	PUNCT
eurjchem-1346	117	39	1640	1640	NUM
eurjchem-1346	117	40	,	,	PUNCT
eurjchem-1346	117	41	1618	1618	NUM
eurjchem-1346	117	42	,	,	PUNCT
eurjchem-1346	117	43	1593	1593	NUM
eurjchem-1346	117	44	,	,	PUNCT
eurjchem-1346	117	45	1580	1580	NUM
eurjchem-1346	117	46	,	,	PUNCT
eurjchem-1346	117	47	1540	1540	NUM
eurjchem-1346	117	48	(	(	PUNCT
eurjchem-1346	117	49	c	c	NOUN
eurjchem-1346	117	50	=	=	SYM
eurjchem-1346	117	51	n	n	X
eurjchem-1346	117	52	,	,	PUNCT
eurjchem-1346	117	53	nh	nh	PROPN
eurjchem-1346	117	54	,	,	PUNCT
eurjchem-1346	117	55	c	c	X
eurjchem-1346	117	56	=	=	SYM
eurjchem-1346	117	57	c	c	NOUN
eurjchem-1346	117	58	)	)	PUNCT
eurjchem-1346	117	59	.	.	PUNCT
eurjchem-1346	118	1	1h	1h	NUM
eurjchem-1346	118	2	nmr	nmr	NOUN
eurjchem-1346	118	3	(	(	PUNCT
eurjchem-1346	118	4	300	300	NUM
eurjchem-1346	118	5	mhz	mhz	NOUN
eurjchem-1346	118	6	,	,	PUNCT
eurjchem-1346	118	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	118	8	,	,	PUNCT
eurjchem-1346	118	9	δ	δ	PROPN
eurjchem-1346	118	10	,	,	PUNCT
eurjchem-1346	118	11	ppm	ppm	NUM
eurjchem-1346	118	12	):	):	PUNCT
eurjchem-1346	118	13	2.04	2.04	NUM
eurjchem-1346	118	14	(	(	PUNCT
eurjchem-1346	118	15	t	t	PROPN
eurjchem-1346	118	16	,	,	PUNCT
eurjchem-1346	118	17	4h	4h	NUM
eurjchem-1346	118	18	,	,	PUNCT
eurjchem-1346	118	19	morpholine	morpholine	ADJ
eurjchem-1346	118	20	h	h	NOUN
eurjchem-1346	118	21	)	)	PUNCT
eurjchem-1346	118	22	,	,	PUNCT
eurjchem-1346	118	23	2.41	2.41	NUM
eurjchem-1346	118	24	(	(	PUNCT
eurjchem-1346	118	25	s	s	PROPN
eurjchem-1346	118	26	,	,	PUNCT
eurjchem-1346	118	27	2h	2h	NUM
eurjchem-1346	118	28	,	,	PUNCT
eurjchem-1346	118	29	ch2	ch2	PROPN
eurjchem-1346	118	30	)	)	PUNCT
eurjchem-1346	118	31	,	,	PUNCT
eurjchem-1346	118	32	3.30	3.30	NUM
eurjchem-1346	118	33	(	(	PUNCT
eurjchem-1346	118	34	t	t	PROPN
eurjchem-1346	118	35	,	,	PUNCT
eurjchem-1346	118	36	4h	4h	NUM
eurjchem-1346	118	37	,	,	PUNCT
eurjchem-1346	118	38	morpholine	morpholine	ADJ
eurjchem-1346	118	39	h	h	NOUN
eurjchem-1346	118	40	)	)	PUNCT
eurjchem-1346	118	41	,	,	PUNCT
eurjchem-1346	118	42	7.33	7.33	NUM
eurjchem-1346	118	43	(	(	PUNCT
eurjchem-1346	118	44	d	d	PROPN
eurjchem-1346	118	45	,	,	PUNCT
eurjchem-1346	118	46	j	j	PROPN
eurjchem-1346	118	47	=	=	SYM
eurjchem-1346	118	48	8.0	8.0	NUM
eurjchem-1346	118	49	hz	hz	NOUN
eurjchem-1346	118	50	,	,	PUNCT
eurjchem-1346	118	51	1h	1h	NUM
eurjchem-1346	118	52	,	,	PUNCT
eurjchem-1346	118	53	h‐8ar	h‐8ar	NOUN
eurjchem-1346	118	54	)	)	PUNCT
eurjchem-1346	118	55	,	,	PUNCT
eurjchem-1346	118	56	7.75	7.75	NUM
eurjchem-1346	118	57	(	(	PUNCT
eurjchem-1346	118	58	t	t	PROPN
eurjchem-1346	118	59	,	,	PUNCT
eurjchem-1346	118	60	1h	1h	NUM
eurjchem-1346	118	61	,	,	PUNCT
eurjchem-1346	118	62	h‐7ar	h‐7ar	NOUN
eurjchem-1346	118	63	)	)	PUNCT
eurjchem-1346	118	64	,	,	PUNCT
eurjchem-1346	118	65	8.12	8.12	NUM
eurjchem-1346	118	66	(	(	PUNCT
eurjchem-1346	118	67	d	d	PROPN
eurjchem-1346	118	68	,	,	PUNCT
eurjchem-1346	118	69	j	j	PROPN
eurjchem-1346	119	1	=	=	SYM
eurjchem-1346	119	2	7.4	7.4	NUM
eurjchem-1346	119	3	hz	hz	NOUN
eurjchem-1346	119	4	,	,	PUNCT
eurjchem-1346	119	5	1h	1h	NUM
eurjchem-1346	119	6	,	,	PUNCT
eurjchem-1346	119	7	h‐6ar	h‐6ar	NOUN
eurjchem-1346	119	8	)	)	PUNCT
eurjchem-1346	119	9	,	,	PUNCT
eurjchem-1346	119	10	10.89	10.89	NUM
eurjchem-1346	119	11	(	(	PUNCT
eurjchem-1346	119	12	s	s	PROPN
eurjchem-1346	119	13	,	,	PUNCT
eurjchem-1346	119	14	1h	1h	NUM
eurjchem-1346	119	15	,	,	PUNCT
eurjchem-1346	119	16	nh	nh	PROPN
eurjchem-1346	119	17	,	,	PUNCT
eurjchem-1346	119	18	exchanged	exchange	VERB
eurjchem-1346	119	19	with	with	ADP
eurjchem-1346	119	20	d2o	d2o	NOUN
eurjchem-1346	119	21	)	)	PUNCT
eurjchem-1346	119	22	.	.	PUNCT
eurjchem-1346	120	1	anal	anal	PROPN
eurjchem-1346	120	2	.	.	PUNCT
eurjchem-1346	120	3	calcd	calcd	NOUN
eurjchem-1346	120	4	.	.	PUNCT
eurjchem-1346	121	1	for	for	SCONJ
eurjchem-1346	121	2	c12h14n4o2	c12h14n4o2	PROPN
eurjchem-1346	121	3	:	:	PUNCT
eurjchem-1346	121	4	c	c	X
eurjchem-1346	121	5	,	,	PUNCT
eurjchem-1346	121	6	58.53	58.53	NUM
eurjchem-1346	121	7	;	;	PUNCT
eurjchem-1346	121	8	h	h	NOUN
eurjchem-1346	121	9	,	,	PUNCT
eurjchem-1346	121	10	5.73	5.73	NUM
eurjchem-1346	121	11	;	;	PUNCT
eurjchem-1346	121	12	n	n	CCONJ
eurjchem-1346	121	13	,	,	PUNCT
eurjchem-1346	121	14	22.75	22.75	NUM
eurjchem-1346	121	15	.	.	PUNCT
eurjchem-1346	121	16	found	find	VERB
eurjchem-1346	121	17	:	:	PUNCT
eurjchem-1346	122	1	c	c	X
eurjchem-1346	122	2	,	,	PUNCT
eurjchem-1346	122	3	58.61	58.61	NUM
eurjchem-1346	122	4	;	;	PUNCT
eurjchem-1346	123	1	h	h	NOUN
eurjchem-1346	123	2	,	,	PUNCT
eurjchem-1346	123	3	5.71	5.71	NUM
eurjchem-1346	123	4	;	;	PUNCT
eurjchem-1346	123	5	n	n	CCONJ
eurjchem-1346	123	6	,	,	PUNCT
eurjchem-1346	123	7	22.92	22.92	NUM
eurjchem-1346	123	8	%	%	NOUN
eurjchem-1346	123	9	.	.	PUNCT
eurjchem-1346	124	1	3‐phenylaminomethylpyrido[2,3‐b]pyrazin‐2(1h)one	3‐phenylaminomethylpyrido[2,3‐b]pyrazin‐2(1h)one	NUM
eurjchem-1346	124	2	(	(	PUNCT
eurjchem-1346	124	3	3d	3d	NUM
eurjchem-1346	124	4	):	):	PUNCT
eurjchem-1346	124	5	yield	yield	NOUN
eurjchem-1346	124	6	:	:	PUNCT
eurjchem-1346	124	7	60	60	NUM
eurjchem-1346	124	8	%	%	NOUN
eurjchem-1346	124	9	.	.	PUNCT
eurjchem-1346	125	1	m.p	m.p	PROPN
eurjchem-1346	125	2	.	.	PROPN
eurjchem-1346	125	3	:	:	PUNCT
eurjchem-1346	126	1	248‐250	248‐250	NUM
eurjchem-1346	126	2	°	°	PROPN
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eurjchem-1346	126	4	.	.	PUNCT
eurjchem-1346	126	5	ft‐ir	ft‐ir	NOUN
eurjchem-1346	126	6	(	(	PUNCT
eurjchem-1346	126	7	kbr	kbr	PROPN
eurjchem-1346	126	8	,	,	PUNCT
eurjchem-1346	126	9			PROPN
eurjchem-1346	126	10	,	,	PUNCT
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eurjchem-1346	126	12	):	):	PUNCT
eurjchem-1346	126	13	3404	3404	NUM
eurjchem-1346	126	14	,	,	PUNCT
eurjchem-1346	126	15	3385	3385	NUM
eurjchem-1346	126	16	(	(	PUNCT
eurjchem-1346	126	17	2nh	2nh	NOUN
eurjchem-1346	126	18	)	)	PUNCT
eurjchem-1346	126	19	,	,	PUNCT
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eurjchem-1346	126	21	(	(	PUNCT
eurjchem-1346	126	22	ch	ch	PROPN
eurjchem-1346	126	23	ar	ar	PROPN
eurjchem-1346	126	24	)	)	PUNCT
eurjchem-1346	126	25	,	,	PUNCT
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eurjchem-1346	126	27	,	,	PUNCT
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eurjchem-1346	126	29	(	(	PUNCT
eurjchem-1346	126	30	ch	ch	NOUN
eurjchem-1346	126	31	aliph	aliph	PROPN
eurjchem-1346	126	32	)	)	PUNCT
eurjchem-1346	126	33	,	,	PUNCT
eurjchem-1346	126	34	1672	1672	NUM
eurjchem-1346	126	35	(	(	PUNCT
eurjchem-1346	126	36	c	c	NOUN
eurjchem-1346	126	37	=	=	NOUN
eurjchem-1346	126	38	o	o	NOUN
eurjchem-1346	126	39	)	)	PUNCT
eurjchem-1346	126	40	,	,	PUNCT
eurjchem-1346	126	41	1593	1593	NUM
eurjchem-1346	126	42	,	,	PUNCT
eurjchem-1346	126	43	1560	1560	NUM
eurjchem-1346	126	44	,	,	PUNCT
eurjchem-1346	126	45	1521	1521	NUM
eurjchem-1346	126	46	,	,	PUNCT
eurjchem-1346	126	47	1508	1508	NUM
eurjchem-1346	126	48	(	(	PUNCT
eurjchem-1346	126	49	c	c	NOUN
eurjchem-1346	126	50	=	=	SYM
eurjchem-1346	126	51	n	n	X
eurjchem-1346	126	52	,	,	PUNCT
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eurjchem-1346	126	54	,	,	PUNCT
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eurjchem-1346	126	56	=	=	SYM
eurjchem-1346	126	57	c	c	NOUN
eurjchem-1346	126	58	)	)	PUNCT
eurjchem-1346	126	59	.	.	PUNCT
eurjchem-1346	127	1	1h	1h	NUM
eurjchem-1346	127	2	nmr	nmr	NOUN
eurjchem-1346	127	3	(	(	PUNCT
eurjchem-1346	127	4	400	400	NUM
eurjchem-1346	127	5	mhz	mhz	NOUN
eurjchem-1346	127	6	,	,	PUNCT
eurjchem-1346	127	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	127	8	,	,	PUNCT
eurjchem-1346	127	9	δ	δ	PROPN
eurjchem-1346	127	10	,	,	PUNCT
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eurjchem-1346	127	12	):	):	PUNCT
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eurjchem-1346	127	14	(	(	PUNCT
eurjchem-1346	127	15	s	s	PROPN
eurjchem-1346	127	16	,	,	PUNCT
eurjchem-1346	127	17	2h	2h	NUM
eurjchem-1346	127	18	,	,	PUNCT
eurjchem-1346	127	19	ch2	ch2	PROPN
eurjchem-1346	127	20	)	)	PUNCT
eurjchem-1346	127	21	,	,	PUNCT
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eurjchem-1346	127	23	(	(	PUNCT
eurjchem-1346	127	24	m	m	PROPN
eurjchem-1346	127	25	,	,	PUNCT
eurjchem-1346	127	26	5h	5h	NUM
eurjchem-1346	127	27	,	,	PUNCT
eurjchem-1346	127	28	h‐2	h‐2	X
eurjchem-1346	127	29	’	'	PUNCT
eurjchem-1346	127	30	,	,	PUNCT
eurjchem-1346	127	31	3	3	NUM
eurjchem-1346	127	32	’	'	PUNCT
eurjchem-1346	127	33	,	,	PUNCT
eurjchem-1346	127	34	4	4	NUM
eurjchem-1346	127	35	’	'	PUNCT
eurjchem-1346	127	36	,	,	PUNCT
eurjchem-1346	127	37	5	5	NUM
eurjchem-1346	127	38	’	'	PUNCT
eurjchem-1346	127	39	,	,	PUNCT
eurjchem-1346	127	40	6	6	NUM
eurjchem-1346	127	41	’	'	PUNCT
eurjchem-1346	127	42	ar	ar	NOUN
eurjchem-1346	127	43	)	)	PUNCT
eurjchem-1346	127	44	,	,	PUNCT
eurjchem-1346	127	45	7.21	7.21	NUM
eurjchem-1346	127	46	(	(	PUNCT
eurjchem-1346	127	47	d	d	PROPN
eurjchem-1346	127	48	,	,	PUNCT
eurjchem-1346	127	49	j	j	PROPN
eurjchem-1346	127	50	=	=	SYM
eurjchem-1346	127	51	9.6	9.6	NUM
eurjchem-1346	127	52	hz	hz	NOUN
eurjchem-1346	127	53	,	,	PUNCT
eurjchem-1346	127	54	1h	1h	NUM
eurjchem-1346	127	55	,	,	PUNCT
eurjchem-1346	127	56	h‐8ar	h‐8ar	NOUN
eurjchem-1346	127	57	)	)	PUNCT
eurjchem-1346	127	58	,	,	PUNCT
eurjchem-1346	127	59	7.50	7.50	NUM
eurjchem-1346	127	60	(	(	PUNCT
eurjchem-1346	127	61	t	t	PROPN
eurjchem-1346	127	62	,	,	PUNCT
eurjchem-1346	127	63	1h	1h	NUM
eurjchem-1346	127	64	,	,	PUNCT
eurjchem-1346	127	65	h‐7ar	h‐7ar	NOUN
eurjchem-1346	127	66	)	)	PUNCT
eurjchem-1346	127	67	,	,	PUNCT
eurjchem-1346	127	68	8.17	8.17	NUM
eurjchem-1346	127	69	(	(	PUNCT
eurjchem-1346	127	70	d	d	PROPN
eurjchem-1346	127	71	,	,	PUNCT
eurjchem-1346	127	72	j	j	PROPN
eurjchem-1346	127	73	=	=	PROPN
eurjchem-1346	127	74	8.2	8.2	NUM
eurjchem-1346	127	75	hz	hz	NOUN
eurjchem-1346	127	76	,	,	PUNCT
eurjchem-1346	127	77	1h	1h	NUM
eurjchem-1346	127	78	,	,	PUNCT
eurjchem-1346	127	79	h‐6ar	h‐6ar	NOUN
eurjchem-1346	127	80	)	)	PUNCT
eurjchem-1346	127	81	,	,	PUNCT
eurjchem-1346	127	82	10.62	10.62	NUM
eurjchem-1346	127	83	(	(	PUNCT
eurjchem-1346	127	84	s	s	PROPN
eurjchem-1346	127	85	,	,	PUNCT
eurjchem-1346	127	86	1h	1h	NUM
eurjchem-1346	127	87	,	,	PUNCT
eurjchem-1346	127	88	nh	nh	PROPN
eurjchem-1346	127	89	,	,	PUNCT
eurjchem-1346	127	90	exchanged	exchange	VERB
eurjchem-1346	127	91	with	with	ADP
eurjchem-1346	127	92	d2o	d2o	NOUN
eurjchem-1346	127	93	)	)	PUNCT
eurjchem-1346	127	94	,	,	PUNCT
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eurjchem-1346	127	96	(	(	PUNCT
eurjchem-1346	127	97	s	s	PROPN
eurjchem-1346	127	98	,	,	PUNCT
eurjchem-1346	127	99	1h	1h	NUM
eurjchem-1346	127	100	,	,	PUNCT
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eurjchem-1346	127	102	,	,	PUNCT
eurjchem-1346	127	103	exchanged	exchange	VERB
eurjchem-1346	127	104	with	with	ADP
eurjchem-1346	127	105	d2o	d2o	NOUN
eurjchem-1346	127	106	)	)	PUNCT
eurjchem-1346	127	107	.	.	PUNCT
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eurjchem-1346	128	2	.	.	PUNCT
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eurjchem-1346	128	4	.	.	PUNCT
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eurjchem-1346	129	2	c14h12n4o	c14h12n4o	NOUN
eurjchem-1346	129	3	:	:	PUNCT
eurjchem-1346	129	4	c	c	X
eurjchem-1346	129	5	,	,	PUNCT
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eurjchem-1346	129	7	;	;	PUNCT
eurjchem-1346	129	8	h	h	NOUN
eurjchem-1346	129	9	,	,	PUNCT
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eurjchem-1346	129	11	;	;	PUNCT
eurjchem-1346	129	12	n	n	CCONJ
eurjchem-1346	129	13	,	,	PUNCT
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eurjchem-1346	129	15	.	.	PUNCT
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eurjchem-1346	129	17	:	:	PUNCT
eurjchem-1346	130	1	c	c	X
eurjchem-1346	130	2	,	,	PUNCT
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eurjchem-1346	130	4	;	;	PUNCT
eurjchem-1346	131	1	h	h	NOUN
eurjchem-1346	131	2	,	,	PUNCT
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eurjchem-1346	131	4	;	;	PUNCT
eurjchem-1346	131	5	n	n	CCONJ
eurjchem-1346	131	6	,	,	PUNCT
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eurjchem-1346	131	9	.	.	PUNCT
eurjchem-1346	132	1	3‐(2‐methylphenyl)aminomethylpyrido[2,3‐b]pyrazin‐2(1h	3‐(2‐methylphenyl)aminomethylpyrido[2,3‐b]pyrazin‐2(1h	NUM
eurjchem-1346	132	2	)	)	PUNCT
eurjchem-1346	132	3	one	one	NUM
eurjchem-1346	132	4	(	(	PUNCT
eurjchem-1346	132	5	3e	3e	NUM
eurjchem-1346	132	6	):	):	PUNCT
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eurjchem-1346	132	8	:	:	PUNCT
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eurjchem-1346	133	2	.	.	PROPN
eurjchem-1346	133	3	:	:	PUNCT
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eurjchem-1346	134	2	c	c	X
eurjchem-1346	134	3	.	.	PUNCT
eurjchem-1346	135	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	135	2	(	(	PUNCT
eurjchem-1346	135	3	kbr	kbr	PROPN
eurjchem-1346	135	4	,	,	PUNCT
eurjchem-1346	135	5			PROPN
eurjchem-1346	135	6	,	,	PUNCT
eurjchem-1346	135	7	cm‐1	cm‐1	PROPN
eurjchem-1346	135	8	):	):	PUNCT
eurjchem-1346	135	9	3414	3414	NUM
eurjchem-1346	135	10	,	,	PUNCT
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eurjchem-1346	135	12	(	(	PUNCT
eurjchem-1346	135	13	2nh	2nh	NOUN
eurjchem-1346	135	14	)	)	PUNCT
eurjchem-1346	135	15	,	,	PUNCT
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eurjchem-1346	135	17	(	(	PUNCT
eurjchem-1346	135	18	ch	ch	PROPN
eurjchem-1346	135	19	ar	ar	PROPN
eurjchem-1346	135	20	)	)	PUNCT
eurjchem-1346	135	21	,	,	PUNCT
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eurjchem-1346	135	23	,	,	PUNCT
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eurjchem-1346	135	25	(	(	PUNCT
eurjchem-1346	135	26	ch	ch	NOUN
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eurjchem-1346	135	28	)	)	PUNCT
eurjchem-1346	135	29	,	,	PUNCT
eurjchem-1346	135	30	1672	1672	NUM
eurjchem-1346	135	31	(	(	PUNCT
eurjchem-1346	135	32	c	c	NOUN
eurjchem-1346	135	33	=	=	NOUN
eurjchem-1346	135	34	o	o	NOUN
eurjchem-1346	135	35	)	)	PUNCT
eurjchem-1346	135	36	,	,	PUNCT
eurjchem-1346	135	37	1649	1649	NUM
eurjchem-1346	135	38	,	,	PUNCT
eurjchem-1346	135	39	1622	1622	NUM
eurjchem-1346	135	40	,	,	PUNCT
eurjchem-1346	135	41	1593	1593	NUM
eurjchem-1346	135	42	,	,	PUNCT
eurjchem-1346	135	43	1570	1570	NUM
eurjchem-1346	135	44	,	,	PUNCT
eurjchem-1346	135	45	1521	1521	NUM
eurjchem-1346	135	46	(	(	PUNCT
eurjchem-1346	135	47	c	c	NOUN
eurjchem-1346	135	48	=	=	SYM
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eurjchem-1346	135	50	,	,	PUNCT
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eurjchem-1346	135	52	,	,	PUNCT
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eurjchem-1346	135	54	=	=	SYM
eurjchem-1346	135	55	c	c	NOUN
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eurjchem-1346	135	57	.	.	PUNCT
eurjchem-1346	136	1	1h	1h	NUM
eurjchem-1346	136	2	nmr	nmr	NOUN
eurjchem-1346	136	3	(	(	PUNCT
eurjchem-1346	136	4	400	400	NUM
eurjchem-1346	136	5	mhz	mhz	NOUN
eurjchem-1346	136	6	,	,	PUNCT
eurjchem-1346	136	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	136	8	,	,	PUNCT
eurjchem-1346	136	9	δ	δ	PROPN
eurjchem-1346	136	10	,	,	PUNCT
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eurjchem-1346	136	12	):	):	PUNCT
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eurjchem-1346	136	14	(	(	PUNCT
eurjchem-1346	136	15	s	s	PROPN
eurjchem-1346	136	16	,	,	PUNCT
eurjchem-1346	136	17	3h	3h	NUM
eurjchem-1346	136	18	,	,	PUNCT
eurjchem-1346	136	19	ch3	ch3	PROPN
eurjchem-1346	136	20	)	)	PUNCT
eurjchem-1346	136	21	,	,	PUNCT
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eurjchem-1346	136	23	(	(	PUNCT
eurjchem-1346	136	24	s	s	PROPN
eurjchem-1346	136	25	,	,	PUNCT
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eurjchem-1346	136	27	,	,	PUNCT
eurjchem-1346	136	28	ch2	ch2	PROPN
eurjchem-1346	136	29	)	)	PUNCT
eurjchem-1346	136	30	,	,	PUNCT
eurjchem-1346	136	31	6.30‐7.00	6.30‐7.00	NUM
eurjchem-1346	136	32	(	(	PUNCT
eurjchem-1346	136	33	m	m	PROPN
eurjchem-1346	136	34	,	,	PUNCT
eurjchem-1346	136	35	4h	4h	NOUN
eurjchem-1346	136	36	,	,	PUNCT
eurjchem-1346	136	37	h‐3	h‐3	NOUN
eurjchem-1346	136	38	’	'	PUNCT
eurjchem-1346	136	39	,	,	PUNCT
eurjchem-1346	136	40	4	4	NUM
eurjchem-1346	136	41	’	'	PUNCT
eurjchem-1346	136	42	,	,	PUNCT
eurjchem-1346	136	43	5	5	NUM
eurjchem-1346	136	44	’	'	PUNCT
eurjchem-1346	136	45	,	,	PUNCT
eurjchem-1346	136	46	6	6	NUM
eurjchem-1346	136	47	’	'	PUNCT
eurjchem-1346	136	48	ar	ar	NOUN
eurjchem-1346	136	49	)	)	PUNCT
eurjchem-1346	136	50	,	,	PUNCT
eurjchem-1346	136	51	7.21	7.21	NUM
eurjchem-1346	136	52	(	(	PUNCT
eurjchem-1346	136	53	d	d	PROPN
eurjchem-1346	136	54	,	,	PUNCT
eurjchem-1346	136	55	j	j	PROPN
eurjchem-1346	136	56	=	=	SYM
eurjchem-1346	136	57	7.2	7.2	NUM
eurjchem-1346	136	58	hz	hz	NOUN
eurjchem-1346	136	59	,	,	PUNCT
eurjchem-1346	136	60	1h	1h	NUM
eurjchem-1346	136	61	,	,	PUNCT
eurjchem-1346	136	62	h‐8ar	h‐8ar	NOUN
eurjchem-1346	136	63	)	)	PUNCT
eurjchem-1346	136	64	,	,	PUNCT
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eurjchem-1346	136	66	(	(	PUNCT
eurjchem-1346	136	67	t	t	PROPN
eurjchem-1346	136	68	,	,	PUNCT
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eurjchem-1346	136	70	,	,	PUNCT
eurjchem-1346	136	71	h‐7ar	h‐7ar	NOUN
eurjchem-1346	136	72	)	)	PUNCT
eurjchem-1346	136	73	,	,	PUNCT
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eurjchem-1346	136	76	d	d	PROPN
eurjchem-1346	136	77	,	,	PUNCT
eurjchem-1346	136	78	j	j	PROPN
eurjchem-1346	136	79	=	=	SYM
eurjchem-1346	136	80	8.4	8.4	NUM
eurjchem-1346	136	81	hz	hz	NOUN
eurjchem-1346	136	82	,	,	PUNCT
eurjchem-1346	136	83	1h	1h	NUM
eurjchem-1346	136	84	,	,	PUNCT
eurjchem-1346	136	85	h‐6ar	h‐6ar	NOUN
eurjchem-1346	136	86	)	)	PUNCT
eurjchem-1346	136	87	,	,	PUNCT
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eurjchem-1346	136	89	(	(	PUNCT
eurjchem-1346	136	90	s	s	PROPN
eurjchem-1346	136	91	,	,	PUNCT
eurjchem-1346	136	92	1h	1h	NUM
eurjchem-1346	136	93	,	,	PUNCT
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eurjchem-1346	136	95	,	,	PUNCT
eurjchem-1346	136	96	exchanged	exchange	VERB
eurjchem-1346	136	97	with	with	ADP
eurjchem-1346	136	98	d2o	d2o	NOUN
eurjchem-1346	136	99	)	)	PUNCT
eurjchem-1346	136	100	,	,	PUNCT
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eurjchem-1346	136	102	(	(	PUNCT
eurjchem-1346	136	103	s	s	PROPN
eurjchem-1346	136	104	,	,	PUNCT
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eurjchem-1346	136	113	.	.	PUNCT
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eurjchem-1346	137	4	.	.	PUNCT
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eurjchem-1346	138	3	:	:	PUNCT
eurjchem-1346	138	4	c	c	X
eurjchem-1346	138	5	,	,	PUNCT
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eurjchem-1346	138	8	h	h	NOUN
eurjchem-1346	138	9	,	,	PUNCT
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eurjchem-1346	138	12	n	n	CCONJ
eurjchem-1346	138	13	,	,	PUNCT
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eurjchem-1346	138	17	:	:	PUNCT
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eurjchem-1346	139	2	,	,	PUNCT
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eurjchem-1346	139	8	;	;	PUNCT
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eurjchem-1346	140	2	)	)	PUNCT
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eurjchem-1346	140	4	(	(	PUNCT
eurjchem-1346	140	5	3f	3f	NUM
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eurjchem-1346	140	8	:	:	PUNCT
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eurjchem-1346	142	4	.	.	PUNCT
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eurjchem-1346	143	8	):	):	PUNCT
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eurjchem-1346	143	23	,	,	PUNCT
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eurjchem-1346	143	25	(	(	PUNCT
eurjchem-1346	143	26	ch	ch	NOUN
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eurjchem-1346	143	28	)	)	PUNCT
eurjchem-1346	143	29	,	,	PUNCT
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eurjchem-1346	143	36	,	,	PUNCT
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eurjchem-1346	143	38	,	,	PUNCT
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eurjchem-1346	143	42	,	,	PUNCT
eurjchem-1346	143	43	1518	1518	NUM
eurjchem-1346	143	44	(	(	PUNCT
eurjchem-1346	143	45	c	c	NOUN
eurjchem-1346	143	46	=	=	SYM
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eurjchem-1346	143	50	,	,	PUNCT
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eurjchem-1346	143	52	=	=	SYM
eurjchem-1346	143	53	c	c	NOUN
eurjchem-1346	143	54	)	)	PUNCT
eurjchem-1346	143	55	.	.	PUNCT
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eurjchem-1346	144	3	(	(	PUNCT
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eurjchem-1346	144	14	(	(	PUNCT
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eurjchem-1346	144	21	,	,	PUNCT
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eurjchem-1346	144	23	(	(	PUNCT
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eurjchem-1346	144	25	,	,	PUNCT
eurjchem-1346	144	26	2h	2h	NUM
eurjchem-1346	144	27	,	,	PUNCT
eurjchem-1346	144	28	ch2	ch2	PROPN
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eurjchem-1346	144	30	,	,	PUNCT
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eurjchem-1346	144	34	,	,	PUNCT
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eurjchem-1346	144	39	,	,	PUNCT
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eurjchem-1346	144	41	’	'	PUNCT
eurjchem-1346	144	42	,	,	PUNCT
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eurjchem-1346	144	44	’	'	PUNCT
eurjchem-1346	144	45	,	,	PUNCT
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eurjchem-1346	144	47	’	'	PUNCT
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eurjchem-1346	144	49	)	)	PUNCT
eurjchem-1346	144	50	,	,	PUNCT
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eurjchem-1346	144	52	(	(	PUNCT
eurjchem-1346	144	53	d	d	PROPN
eurjchem-1346	144	54	,	,	PUNCT
eurjchem-1346	144	55	j	j	PROPN
eurjchem-1346	144	56	=	=	SYM
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eurjchem-1346	144	64	)	)	PUNCT
eurjchem-1346	144	65	,	,	PUNCT
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eurjchem-1346	144	71	,	,	PUNCT
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eurjchem-1346	144	73	)	)	PUNCT
eurjchem-1346	144	74	,	,	PUNCT
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eurjchem-1346	144	77	d	d	PROPN
eurjchem-1346	144	78	,	,	PUNCT
eurjchem-1346	144	79	j	j	PROPN
eurjchem-1346	144	80	=	=	SYM
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eurjchem-1346	144	83	,	,	PUNCT
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eurjchem-1346	144	88	,	,	PUNCT
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eurjchem-1346	144	100	)	)	PUNCT
eurjchem-1346	144	101	,	,	PUNCT
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eurjchem-1346	144	113	d2o	d2o	NOUN
eurjchem-1346	144	114	)	)	PUNCT
eurjchem-1346	144	115	.	.	PUNCT
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eurjchem-1346	145	2	.	.	PUNCT
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eurjchem-1346	145	4	.	.	PUNCT
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eurjchem-1346	146	2	c15h14n4o	c15h14n4o	NOUN
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eurjchem-1346	146	4	c	c	X
eurjchem-1346	146	5	,	,	PUNCT
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eurjchem-1346	146	9	,	,	PUNCT
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eurjchem-1346	146	17	:	:	PUNCT
eurjchem-1346	147	1	c	c	X
eurjchem-1346	147	2	,	,	PUNCT
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eurjchem-1346	147	4	;	;	PUNCT
eurjchem-1346	147	5	h	h	NOUN
eurjchem-1346	147	6	,	,	PUNCT
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eurjchem-1346	147	8	;	;	PUNCT
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eurjchem-1346	147	10	,	,	PUNCT
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eurjchem-1346	147	13	.	.	PUNCT
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eurjchem-1346	148	5	.	.	PUNCT
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eurjchem-1346	148	16	2016	2016	NUM
eurjchem-1346	148	17	)	)	PUNCT
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eurjchem-1346	148	19	3‐(4‐methylphenyl)aminomethylpyrido[2,3‐b]pyrazin‐2(1h	3‐(4‐methylphenyl)aminomethylpyrido[2,3‐b]pyrazin‐2(1h	NUM
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eurjchem-1346	148	25	):	):	PUNCT
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eurjchem-1346	148	27	:	:	PUNCT
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eurjchem-1346	151	8	):	):	PUNCT
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eurjchem-1346	151	28	)	)	PUNCT
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eurjchem-1346	151	33	=	=	NOUN
eurjchem-1346	151	34	o	o	NOUN
eurjchem-1346	151	35	)	)	PUNCT
eurjchem-1346	151	36	,	,	PUNCT
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eurjchem-1346	151	44	(	(	PUNCT
eurjchem-1346	151	45	c	c	NOUN
eurjchem-1346	151	46	=	=	SYM
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eurjchem-1346	151	50	,	,	PUNCT
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eurjchem-1346	151	52	=	=	SYM
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eurjchem-1346	151	54	)	)	PUNCT
eurjchem-1346	151	55	.	.	PUNCT
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eurjchem-1346	152	3	(	(	PUNCT
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eurjchem-1346	152	10	,	,	PUNCT
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eurjchem-1346	152	20	)	)	PUNCT
eurjchem-1346	152	21	,	,	PUNCT
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eurjchem-1346	152	30	,	,	PUNCT
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eurjchem-1346	152	34	,	,	PUNCT
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eurjchem-1346	152	56	=	=	SYM
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eurjchem-1346	155	2	,	,	PUNCT
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eurjchem-1346	155	5	h	h	NOUN
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eurjchem-1346	155	13	.	.	PUNCT
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eurjchem-1346	156	2	,	,	PUNCT
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eurjchem-1346	156	4	)	)	PUNCT
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eurjchem-1346	156	7	3h	3h	NUM
eurjchem-1346	156	8	):	):	PUNCT
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eurjchem-1346	156	10	:	:	PUNCT
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eurjchem-1346	159	28	)	)	PUNCT
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eurjchem-1346	160	21	,	,	PUNCT
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eurjchem-1346	160	52	1h	1h	NUM
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eurjchem-1346	162	17	:	:	PUNCT
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eurjchem-1346	163	2	,	,	PUNCT
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eurjchem-1346	163	6	,	,	PUNCT
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eurjchem-1346	163	10	,	,	PUNCT
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eurjchem-1346	164	5	3i	3i	NOUN
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eurjchem-1346	164	8	:	:	PUNCT
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eurjchem-1346	168	21	,	,	PUNCT
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eurjchem-1346	168	27	,	,	PUNCT
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eurjchem-1346	168	29	’	'	PUNCT
eurjchem-1346	168	30	,	,	PUNCT
eurjchem-1346	168	31	3	3	NUM
eurjchem-1346	168	32	’	'	PUNCT
eurjchem-1346	168	33	,	,	PUNCT
eurjchem-1346	168	34	5	5	NUM
eurjchem-1346	168	35	’	'	PUNCT
eurjchem-1346	168	36	,	,	PUNCT
eurjchem-1346	168	37	6	6	NUM
eurjchem-1346	168	38	’	'	PUNCT
eurjchem-1346	168	39	ar	ar	NOUN
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eurjchem-1346	168	41	,	,	PUNCT
eurjchem-1346	168	42	7.41	7.41	NUM
eurjchem-1346	168	43	(	(	PUNCT
eurjchem-1346	168	44	d	d	NOUN
eurjchem-1346	168	45	,	,	PUNCT
eurjchem-1346	168	46	j	j	PROPN
eurjchem-1346	168	47	=	=	SYM
eurjchem-1346	168	48	8.1	8.1	NUM
eurjchem-1346	168	49	hz	hz	NOUN
eurjchem-1346	168	50	,	,	PUNCT
eurjchem-1346	168	51	1h	1h	NUM
eurjchem-1346	168	52	,	,	PUNCT
eurjchem-1346	168	53	h‐8ar	h‐8ar	NOUN
eurjchem-1346	168	54	)	)	PUNCT
eurjchem-1346	168	55	,	,	PUNCT
eurjchem-1346	168	56	7.69	7.69	NUM
eurjchem-1346	168	57	(	(	PUNCT
eurjchem-1346	168	58	t	t	PROPN
eurjchem-1346	168	59	,	,	PUNCT
eurjchem-1346	168	60	1h	1h	NUM
eurjchem-1346	168	61	,	,	PUNCT
eurjchem-1346	168	62	h‐7ar	h‐7ar	NOUN
eurjchem-1346	168	63	)	)	PUNCT
eurjchem-1346	168	64	,	,	PUNCT
eurjchem-1346	168	65	8.22	8.22	NUM
eurjchem-1346	168	66	(	(	PUNCT
eurjchem-1346	168	67	d	d	PROPN
eurjchem-1346	168	68	,	,	PUNCT
eurjchem-1346	168	69	j	j	PROPN
eurjchem-1346	168	70	=	=	SYM
eurjchem-1346	168	71	6.0	6.0	NUM
eurjchem-1346	168	72	hz	hz	NOUN
eurjchem-1346	168	73	,	,	PUNCT
eurjchem-1346	168	74	1h	1h	NUM
eurjchem-1346	168	75	,	,	PUNCT
eurjchem-1346	168	76	h‐6ar	h‐6ar	NOUN
eurjchem-1346	168	77	)	)	PUNCT
eurjchem-1346	168	78	,	,	PUNCT
eurjchem-1346	168	79	11.02	11.02	NUM
eurjchem-1346	168	80	(	(	PUNCT
eurjchem-1346	168	81	s	s	PROPN
eurjchem-1346	168	82	,	,	PUNCT
eurjchem-1346	168	83	1h	1h	NUM
eurjchem-1346	168	84	,	,	PUNCT
eurjchem-1346	168	85	nh	nh	PROPN
eurjchem-1346	168	86	,	,	PUNCT
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eurjchem-1346	168	88	with	with	ADP
eurjchem-1346	168	89	d2o	d2o	NOUN
eurjchem-1346	168	90	)	)	PUNCT
eurjchem-1346	168	91	,	,	PUNCT
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eurjchem-1346	168	93	(	(	PUNCT
eurjchem-1346	168	94	s	s	PROPN
eurjchem-1346	168	95	,	,	PUNCT
eurjchem-1346	168	96	1h	1h	NUM
eurjchem-1346	168	97	,	,	PUNCT
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eurjchem-1346	168	99	,	,	PUNCT
eurjchem-1346	168	100	exchanged	exchange	VERB
eurjchem-1346	168	101	with	with	ADP
eurjchem-1346	168	102	d2o	d2o	NOUN
eurjchem-1346	168	103	)	)	PUNCT
eurjchem-1346	168	104	.	.	PUNCT
eurjchem-1346	169	1	anal	anal	PROPN
eurjchem-1346	169	2	.	.	PUNCT
eurjchem-1346	169	3	calcd	calcd	NOUN
eurjchem-1346	169	4	.	.	PUNCT
eurjchem-1346	170	1	for	for	ADP
eurjchem-1346	170	2	c14h11brn4o	c14h11brn4o	NOUN
eurjchem-1346	170	3	:	:	SYM
eurjchem-1346	170	4	c	c	NOUN
eurjchem-1346	170	5	,	,	PUNCT
eurjchem-1346	170	6	50.77	50.77	NUM
eurjchem-1346	170	7	;	;	PUNCT
eurjchem-1346	170	8	h	h	X
eurjchem-1346	170	9	,	,	PUNCT
eurjchem-1346	170	10	3.35	3.35	NUM
eurjchem-1346	170	11	;	;	PUNCT
eurjchem-1346	170	12	n	n	CCONJ
eurjchem-1346	170	13	,	,	PUNCT
eurjchem-1346	170	14	16.92	16.92	NUM
eurjchem-1346	170	15	.	.	PUNCT
eurjchem-1346	170	16	found	find	VERB
eurjchem-1346	170	17	:	:	PUNCT
eurjchem-1346	171	1	c	c	X
eurjchem-1346	171	2	,	,	PUNCT
eurjchem-1346	171	3	50.91	50.91	NUM
eurjchem-1346	171	4	;	;	PUNCT
eurjchem-1346	171	5	h	h	NOUN
eurjchem-1346	171	6	,	,	PUNCT
eurjchem-1346	171	7	3.37	3.37	NUM
eurjchem-1346	171	8	;	;	PUNCT
eurjchem-1346	171	9	n	n	CCONJ
eurjchem-1346	171	10	,	,	PUNCT
eurjchem-1346	171	11	16.98	16.98	NUM
eurjchem-1346	171	12	%	%	NOUN
eurjchem-1346	171	13	.	.	PUNCT
eurjchem-1346	172	1	3‐(n	3‐(n	NOUN
eurjchem-1346	172	2	,	,	PUNCT
eurjchem-1346	172	3	n‐diphenylamino)methylpyrido[2	n‐diphenylamino)methylpyrido[2	PROPN
eurjchem-1346	172	4	,	,	PUNCT
eurjchem-1346	172	5	3‐b]pyrazin‐2(1h	3‐b]pyrazin‐2(1h	X
eurjchem-1346	172	6	)	)	PUNCT
eurjchem-1346	172	7	one	one	NUM
eurjchem-1346	172	8	(	(	PUNCT
eurjchem-1346	172	9	3j	3j	NUM
eurjchem-1346	172	10	):	):	PUNCT
eurjchem-1346	172	11	yield	yield	NOUN
eurjchem-1346	172	12	:	:	PUNCT
eurjchem-1346	172	13	46	46	NUM
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eurjchem-1346	172	15	.	.	PUNCT
eurjchem-1346	173	1	m.p	m.p	PROPN
eurjchem-1346	173	2	.	.	PROPN
eurjchem-1346	173	3	:	:	PUNCT
eurjchem-1346	174	1	292‐293	292‐293	NUM
eurjchem-1346	174	2	°	°	ADP
eurjchem-1346	174	3	c	c	NOUN
eurjchem-1346	174	4	.	.	PUNCT
eurjchem-1346	175	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	175	2	(	(	PUNCT
eurjchem-1346	175	3	kbr	kbr	PROPN
eurjchem-1346	175	4	,	,	PUNCT
eurjchem-1346	175	5			PROPN
eurjchem-1346	175	6	,	,	PUNCT
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eurjchem-1346	175	8	):	):	PUNCT
eurjchem-1346	175	9	3410	3410	NUM
eurjchem-1346	175	10	(	(	PUNCT
eurjchem-1346	175	11	nh	nh	NOUN
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eurjchem-1346	175	13	,	,	PUNCT
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eurjchem-1346	175	15	(	(	PUNCT
eurjchem-1346	175	16	ch	ch	PROPN
eurjchem-1346	175	17	ar	ar	PROPN
eurjchem-1346	175	18	)	)	PUNCT
eurjchem-1346	175	19	,	,	PUNCT
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eurjchem-1346	175	21	,	,	PUNCT
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eurjchem-1346	175	23	(	(	PUNCT
eurjchem-1346	175	24	ch	ch	NOUN
eurjchem-1346	175	25	aliph	aliph	PROPN
eurjchem-1346	175	26	)	)	PUNCT
eurjchem-1346	175	27	,	,	PUNCT
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eurjchem-1346	175	29	(	(	PUNCT
eurjchem-1346	175	30	c	c	NOUN
eurjchem-1346	175	31	=	=	NOUN
eurjchem-1346	175	32	o	o	NOUN
eurjchem-1346	175	33	)	)	PUNCT
eurjchem-1346	175	34	,	,	PUNCT
eurjchem-1346	175	35	1649	1649	NUM
eurjchem-1346	175	36	,	,	PUNCT
eurjchem-1346	175	37	1610	1610	NUM
eurjchem-1346	175	38	,	,	PUNCT
eurjchem-1346	175	39	1591	1591	NUM
eurjchem-1346	175	40	,	,	PUNCT
eurjchem-1346	175	41	1570	1570	NUM
eurjchem-1346	175	42	,	,	PUNCT
eurjchem-1346	175	43	1508	1508	NUM
eurjchem-1346	175	44	(	(	PUNCT
eurjchem-1346	175	45	c	c	NOUN
eurjchem-1346	175	46	=	=	SYM
eurjchem-1346	175	47	n	n	X
eurjchem-1346	175	48	,	,	PUNCT
eurjchem-1346	175	49	nh	nh	PROPN
eurjchem-1346	175	50	,	,	PUNCT
eurjchem-1346	175	51	c	c	X
eurjchem-1346	175	52	=	=	SYM
eurjchem-1346	175	53	c	c	NOUN
eurjchem-1346	175	54	)	)	PUNCT
eurjchem-1346	175	55	.	.	PUNCT
eurjchem-1346	176	1	1h	1h	NUM
eurjchem-1346	176	2	nmr	nmr	NOUN
eurjchem-1346	176	3	(	(	PUNCT
eurjchem-1346	176	4	400	400	NUM
eurjchem-1346	176	5	mhz	mhz	NOUN
eurjchem-1346	176	6	,	,	PUNCT
eurjchem-1346	176	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	176	8	,	,	PUNCT
eurjchem-1346	176	9	δ	δ	PROPN
eurjchem-1346	176	10	,	,	PUNCT
eurjchem-1346	176	11	ppm	ppm	NOUN
eurjchem-1346	176	12	):	):	PUNCT
eurjchem-1346	176	13	3.32	3.32	NUM
eurjchem-1346	176	14	(	(	PUNCT
eurjchem-1346	176	15	s	s	PROPN
eurjchem-1346	176	16	,	,	PUNCT
eurjchem-1346	176	17	2h	2h	NUM
eurjchem-1346	176	18	,	,	PUNCT
eurjchem-1346	176	19	ch2	ch2	PROPN
eurjchem-1346	176	20	)	)	PUNCT
eurjchem-1346	176	21	,	,	PUNCT
eurjchem-1346	176	22	6.50‐7.11	6.50‐7.11	NUM
eurjchem-1346	176	23	(	(	PUNCT
eurjchem-1346	176	24	m	m	PROPN
eurjchem-1346	176	25	,	,	PUNCT
eurjchem-1346	176	26	10h	10h	NUM
eurjchem-1346	176	27	,	,	PUNCT
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eurjchem-1346	176	29	h	h	PROPN
eurjchem-1346	176	30	)	)	PUNCT
eurjchem-1346	176	31	,	,	PUNCT
eurjchem-1346	176	32	7.21	7.21	NUM
eurjchem-1346	176	33	(	(	PUNCT
eurjchem-1346	176	34	d	d	PROPN
eurjchem-1346	176	35	,	,	PUNCT
eurjchem-1346	176	36	j	j	PROPN
eurjchem-1346	176	37	=	=	SYM
eurjchem-1346	176	38	7.2	7.2	NUM
eurjchem-1346	176	39	hz	hz	NOUN
eurjchem-1346	176	40	,	,	PUNCT
eurjchem-1346	176	41	1h	1h	NUM
eurjchem-1346	176	42	,	,	PUNCT
eurjchem-1346	176	43	h‐8ar	h‐8ar	NOUN
eurjchem-1346	176	44	)	)	PUNCT
eurjchem-1346	176	45	,	,	PUNCT
eurjchem-1346	176	46	7.55	7.55	NUM
eurjchem-1346	176	47	(	(	PUNCT
eurjchem-1346	176	48	t	t	PROPN
eurjchem-1346	176	49	,	,	PUNCT
eurjchem-1346	176	50	1h	1h	NUM
eurjchem-1346	176	51	,	,	PUNCT
eurjchem-1346	176	52	h‐7ar	h‐7ar	NOUN
eurjchem-1346	176	53	)	)	PUNCT
eurjchem-1346	176	54	,	,	PUNCT
eurjchem-1346	176	55	8.15	8.15	NUM
eurjchem-1346	176	56	(	(	PUNCT
eurjchem-1346	176	57	d	d	PROPN
eurjchem-1346	176	58	,	,	PUNCT
eurjchem-1346	176	59	j	j	PROPN
eurjchem-1346	176	60	=	=	SYM
eurjchem-1346	176	61	7.0	7.0	NUM
eurjchem-1346	176	62	hz	hz	NOUN
eurjchem-1346	176	63	,	,	PUNCT
eurjchem-1346	176	64	1h	1h	NUM
eurjchem-1346	176	65	,	,	PUNCT
eurjchem-1346	176	66	h‐6	h‐6	NOUN
eurjchem-1346	176	67	ar	ar	NOUN
eurjchem-1346	176	68	)	)	PUNCT
eurjchem-1346	176	69	,	,	PUNCT
eurjchem-1346	176	70	11.44	11.44	NUM
eurjchem-1346	176	71	(	(	PUNCT
eurjchem-1346	176	72	s	s	PROPN
eurjchem-1346	176	73	,	,	PUNCT
eurjchem-1346	176	74	1h	1h	NUM
eurjchem-1346	176	75	,	,	PUNCT
eurjchem-1346	176	76	nh	nh	PROPN
eurjchem-1346	176	77	,	,	PUNCT
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eurjchem-1346	176	79	with	with	ADP
eurjchem-1346	176	80	d2o	d2o	NOUN
eurjchem-1346	176	81	)	)	PUNCT
eurjchem-1346	176	82	.	.	PUNCT
eurjchem-1346	177	1	anal	anal	PROPN
eurjchem-1346	177	2	.	.	PUNCT
eurjchem-1346	177	3	calcd	calcd	NOUN
eurjchem-1346	177	4	.	.	PUNCT
eurjchem-1346	178	1	for	for	SCONJ
eurjchem-1346	178	2	c20h16n4o	c20h16n4o	NOUN
eurjchem-1346	178	3	:	:	PUNCT
eurjchem-1346	178	4	c	c	X
eurjchem-1346	178	5	,	,	PUNCT
eurjchem-1346	178	6	73.15	73.15	NUM
eurjchem-1346	178	7	;	;	PUNCT
eurjchem-1346	178	8	h	h	NOUN
eurjchem-1346	178	9	,	,	PUNCT
eurjchem-1346	178	10	4.91	4.91	NUM
eurjchem-1346	178	11	;	;	PUNCT
eurjchem-1346	178	12	n	n	CCONJ
eurjchem-1346	178	13	,	,	PUNCT
eurjchem-1346	178	14	17.06	17.06	NUM
eurjchem-1346	178	15	.	.	PUNCT
eurjchem-1346	178	16	found	find	VERB
eurjchem-1346	178	17	:	:	PUNCT
eurjchem-1346	179	1	c	c	X
eurjchem-1346	179	2	,	,	PUNCT
eurjchem-1346	179	3	73.28	73.28	NUM
eurjchem-1346	179	4	;	;	PUNCT
eurjchem-1346	179	5	h	h	NOUN
eurjchem-1346	179	6	,	,	PUNCT
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eurjchem-1346	179	8	;	;	PUNCT
eurjchem-1346	179	9	n	n	CCONJ
eurjchem-1346	179	10	,	,	PUNCT
eurjchem-1346	179	11	17.22	17.22	NUM
eurjchem-1346	179	12	%	%	NOUN
eurjchem-1346	179	13	.	.	PUNCT
eurjchem-1346	180	1	2.1.4	2.1.4	NUM
eurjchem-1346	180	2	.	.	PUNCT
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eurjchem-1346	180	5	3‐hydrazinomethylpyrido[2,3‐b]pyrazin‐	3‐hydrazinomethylpyrido[2,3‐b]pyrazin‐	NUM
eurjchem-1346	180	6	2(1h)one	2(1h)one	NUM
eurjchem-1346	180	7	(	(	PUNCT
eurjchem-1346	180	8	4	4	NUM
eurjchem-1346	180	9	)	)	PUNCT
eurjchem-1346	180	10	hydrazine	hydrazine	NOUN
eurjchem-1346	180	11	hydrate	hydrate	NOUN
eurjchem-1346	180	12	(	(	PUNCT
eurjchem-1346	180	13	7.00	7.00	NUM
eurjchem-1346	180	14	g	g	NOUN
eurjchem-1346	180	15	,	,	PUNCT
eurjchem-1346	180	16	6.86	6.86	NUM
eurjchem-1346	180	17	ml	ml	NOUN
eurjchem-1346	180	18	,	,	PUNCT
eurjchem-1346	180	19	0.14	0.14	NUM
eurjchem-1346	180	20	mol	mol	NOUN
eurjchem-1346	180	21	)	)	PUNCT
eurjchem-1346	180	22	was	be	AUX
eurjchem-1346	180	23	added	add	VERB
eurjchem-1346	180	24	to	to	ADP
eurjchem-1346	180	25	a	a	DET
eurjchem-1346	180	26	solution	solution	NOUN
eurjchem-1346	180	27	of	of	ADP
eurjchem-1346	180	28	compound	compound	NOUN
eurjchem-1346	180	29	2	2	NUM
eurjchem-1346	180	30	(	(	PUNCT
eurjchem-1346	180	31	2.40	2.40	NUM
eurjchem-1346	180	32	g	g	NOUN
eurjchem-1346	180	33	,	,	PUNCT
eurjchem-1346	180	34	0.01	0.01	NUM
eurjchem-1346	180	35	mol	mol	NOUN
eurjchem-1346	180	36	)	)	PUNCT
eurjchem-1346	180	37	in	in	ADP
eurjchem-1346	180	38	ethanol	ethanol	NOUN
eurjchem-1346	180	39	(	(	PUNCT
eurjchem-1346	180	40	20	20	NUM
eurjchem-1346	180	41	ml	ml	NOUN
eurjchem-1346	180	42	)	)	PUNCT
eurjchem-1346	180	43	and	and	CCONJ
eurjchem-1346	180	44	refluxed	refluxe	VERB
eurjchem-1346	180	45	for	for	ADP
eurjchem-1346	180	46	9	9	NUM
eurjchem-1346	180	47	h.	h.	NOUN
eurjchem-1346	180	48	the	the	DET
eurjchem-1346	180	49	mixture	mixture	NOUN
eurjchem-1346	180	50	was	be	AUX
eurjchem-1346	180	51	cooled	cool	VERB
eurjchem-1346	180	52	in	in	ADP
eurjchem-1346	180	53	ice	ice	NOUN
eurjchem-1346	180	54	bath	bath	NOUN
eurjchem-1346	180	55	for	for	ADP
eurjchem-1346	180	56	10	10	NUM
eurjchem-1346	180	57	min	min	NOUN
eurjchem-1346	180	58	.	.	PROPN
eurjchem-1346	180	59	and	and	CCONJ
eurjchem-1346	180	60	formed	form	VERB
eurjchem-1346	180	61	precipitate	precipitate	NOUN
eurjchem-1346	180	62	was	be	AUX
eurjchem-1346	180	63	filtered	filter	VERB
eurjchem-1346	180	64	.	.	PUNCT
eurjchem-1346	181	1	the	the	DET
eurjchem-1346	181	2	precipitate	precipitate	NOUN
eurjchem-1346	181	3	was	be	AUX
eurjchem-1346	181	4	washed	wash	VERB
eurjchem-1346	181	5	with	with	ADP
eurjchem-1346	181	6	ethanol	ethanol	NOUN
eurjchem-1346	181	7	(	(	PUNCT
eurjchem-1346	181	8	5	5	NUM
eurjchem-1346	181	9	ml	ml	NOUN
eurjchem-1346	181	10	)	)	PUNCT
eurjchem-1346	181	11	and	and	CCONJ
eurjchem-1346	181	12	dried	dry	VERB
eurjchem-1346	181	13	.	.	PUNCT
eurjchem-1346	182	1	the	the	DET
eurjchem-1346	182	2	crude	crude	ADJ
eurjchem-1346	182	3	product	product	NOUN
eurjchem-1346	182	4	was	be	AUX
eurjchem-1346	182	5	crystallized	crystallize	VERB
eurjchem-1346	182	6	from	from	ADP
eurjchem-1346	182	7	ethanol	ethanol	NOUN
eurjchem-1346	182	8	(	(	PUNCT
eurjchem-1346	182	9	scheme	scheme	NOUN
eurjchem-1346	182	10	1	1	NUM
eurjchem-1346	182	11	)	)	PUNCT
eurjchem-1346	182	12	.	.	PUNCT
eurjchem-1346	183	1	yield	yield	NOUN
eurjchem-1346	183	2	:	:	PUNCT
eurjchem-1346	183	3	73	73	NUM
eurjchem-1346	183	4	%	%	NOUN
eurjchem-1346	183	5	.	.	PUNCT
eurjchem-1346	184	1	m.p	m.p	PROPN
eurjchem-1346	184	2	.	.	PROPN
eurjchem-1346	184	3	:	:	PUNCT
eurjchem-1346	185	1	243‐245	243‐245	NUM
eurjchem-1346	185	2	°	°	PROPN
eurjchem-1346	185	3	c	c	X
eurjchem-1346	185	4	.	.	PUNCT
eurjchem-1346	186	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	186	2	(	(	PUNCT
eurjchem-1346	186	3	kbr	kbr	PROPN
eurjchem-1346	186	4	,	,	PUNCT
eurjchem-1346	186	5			PROPN
eurjchem-1346	186	6	,	,	PUNCT
eurjchem-1346	186	7	cm‐1	cm‐1	PROPN
eurjchem-1346	186	8	):	):	PUNCT
eurjchem-1346	186	9	3369	3369	NUM
eurjchem-1346	186	10	,	,	PUNCT
eurjchem-1346	186	11	3329	3329	NUM
eurjchem-1346	186	12	(	(	PUNCT
eurjchem-1346	186	13	nh2	nh2	PROPN
eurjchem-1346	186	14	,	,	PUNCT
eurjchem-1346	186	15	2nh	2nh	NOUN
eurjchem-1346	186	16	)	)	PUNCT
eurjchem-1346	186	17	,	,	PUNCT
eurjchem-1346	186	18	3066	3066	NUM
eurjchem-1346	186	19	(	(	PUNCT
eurjchem-1346	186	20	ch	ch	PROPN
eurjchem-1346	186	21	ar	ar	PROPN
eurjchem-1346	186	22	)	)	PUNCT
eurjchem-1346	186	23	,	,	PUNCT
eurjchem-1346	186	24	2924	2924	NUM
eurjchem-1346	186	25	,	,	PUNCT
eurjchem-1346	186	26	2852	2852	NUM
eurjchem-1346	186	27	(	(	PUNCT
eurjchem-1346	186	28	ch	ch	NOUN
eurjchem-1346	186	29	aliph	aliph	PROPN
eurjchem-1346	186	30	)	)	PUNCT
eurjchem-1346	186	31	,	,	PUNCT
eurjchem-1346	186	32	1670	1670	NUM
eurjchem-1346	186	33	(	(	PUNCT
eurjchem-1346	186	34	c	c	NOUN
eurjchem-1346	186	35	=	=	NOUN
eurjchem-1346	186	36	o	o	NOUN
eurjchem-1346	186	37	)	)	PUNCT
eurjchem-1346	186	38	,	,	PUNCT
eurjchem-1346	186	39	1612	1612	NUM
eurjchem-1346	186	40	,	,	PUNCT
eurjchem-1346	186	41	1591	1591	NUM
eurjchem-1346	186	42	,	,	PUNCT
eurjchem-1346	186	43	1570	1570	NUM
eurjchem-1346	186	44	,	,	PUNCT
eurjchem-1346	186	45	1508	1508	NUM
eurjchem-1346	186	46	(	(	PUNCT
eurjchem-1346	186	47	c	c	NOUN
eurjchem-1346	186	48	=	=	SYM
eurjchem-1346	186	49	n	n	X
eurjchem-1346	186	50	,	,	PUNCT
eurjchem-1346	186	51	nh	nh	PROPN
eurjchem-1346	186	52	,	,	PUNCT
eurjchem-1346	186	53	c	c	X
eurjchem-1346	186	54	=	=	SYM
eurjchem-1346	186	55	c	c	NOUN
eurjchem-1346	186	56	)	)	PUNCT
eurjchem-1346	186	57	.	.	PUNCT
eurjchem-1346	187	1	1h	1h	NUM
eurjchem-1346	187	2	nmr	nmr	NOUN
eurjchem-1346	187	3	(	(	PUNCT
eurjchem-1346	187	4	400	400	NUM
eurjchem-1346	187	5	mhz	mhz	NOUN
eurjchem-1346	187	6	,	,	PUNCT
eurjchem-1346	187	7	dmso‐	dmso‐	NUM
eurjchem-1346	187	8	d6	d6	NOUN
eurjchem-1346	187	9	,	,	PUNCT
eurjchem-1346	187	10	δ	δ	PROPN
eurjchem-1346	187	11	,	,	PUNCT
eurjchem-1346	187	12	ppm	ppm	NOUN
eurjchem-1346	187	13	):	):	PUNCT
eurjchem-1346	187	14	2.51	2.51	NUM
eurjchem-1346	187	15	(	(	PUNCT
eurjchem-1346	187	16	s	s	PROPN
eurjchem-1346	187	17	,	,	PUNCT
eurjchem-1346	187	18	2h	2h	NUM
eurjchem-1346	187	19	,	,	PUNCT
eurjchem-1346	187	20	ch2	ch2	PROPN
eurjchem-1346	187	21	)	)	PUNCT
eurjchem-1346	187	22	,	,	PUNCT
eurjchem-1346	187	23	7.21	7.21	NUM
eurjchem-1346	187	24	(	(	PUNCT
eurjchem-1346	187	25	d	d	PROPN
eurjchem-1346	187	26	,	,	PUNCT
eurjchem-1346	187	27	j	j	PROPN
eurjchem-1346	187	28	=	=	SYM
eurjchem-1346	187	29	6.2	6.2	NUM
eurjchem-1346	187	30	hz	hz	NOUN
eurjchem-1346	187	31	,	,	PUNCT
eurjchem-1346	187	32	1h	1h	NUM
eurjchem-1346	187	33	,	,	PUNCT
eurjchem-1346	187	34	h‐8ar	h‐8ar	NOUN
eurjchem-1346	187	35	)	)	PUNCT
eurjchem-1346	187	36	,	,	PUNCT
eurjchem-1346	187	37	7.50	7.50	NUM
eurjchem-1346	187	38	(	(	PUNCT
eurjchem-1346	187	39	t	t	PROPN
eurjchem-1346	187	40	,	,	PUNCT
eurjchem-1346	187	41	1h	1h	NUM
eurjchem-1346	187	42	,	,	PUNCT
eurjchem-1346	187	43	h‐7ar	h‐7ar	NOUN
eurjchem-1346	187	44	)	)	PUNCT
eurjchem-1346	187	45	,	,	PUNCT
eurjchem-1346	187	46	8.22	8.22	NUM
eurjchem-1346	187	47	(	(	PUNCT
eurjchem-1346	187	48	d	d	PROPN
eurjchem-1346	187	49	,	,	PUNCT
eurjchem-1346	187	50	j	j	PROPN
eurjchem-1346	187	51	=	=	PROPN
eurjchem-1346	187	52	8.2	8.2	NUM
eurjchem-1346	187	53	hz	hz	NOUN
eurjchem-1346	187	54	,	,	PUNCT
eurjchem-1346	187	55	1h	1h	NUM
eurjchem-1346	187	56	,	,	PUNCT
eurjchem-1346	187	57	h‐6ar	h‐6ar	NOUN
eurjchem-1346	187	58	)	)	PUNCT
eurjchem-1346	187	59	,	,	PUNCT
eurjchem-1346	187	60	10.72	10.72	NUM
eurjchem-1346	187	61	(	(	PUNCT
eurjchem-1346	187	62	s	s	PROPN
eurjchem-1346	187	63	,	,	PUNCT
eurjchem-1346	187	64	1h	1h	NUM
eurjchem-1346	187	65	,	,	PUNCT
eurjchem-1346	187	66	nh	nh	PROPN
eurjchem-1346	187	67	,	,	PUNCT
eurjchem-1346	187	68	exchanged	exchange	VERB
eurjchem-1346	187	69	with	with	ADP
eurjchem-1346	187	70	d2o	d2o	NOUN
eurjchem-1346	187	71	)	)	PUNCT
eurjchem-1346	187	72	,	,	PUNCT
eurjchem-1346	187	73	11.22	11.22	NUM
eurjchem-1346	187	74	(	(	PUNCT
eurjchem-1346	187	75	s	s	PROPN
eurjchem-1346	187	76	,	,	PUNCT
eurjchem-1346	187	77	2h	2h	NUM
eurjchem-1346	187	78	,	,	PUNCT
eurjchem-1346	187	79	nh2	nh2	PROPN
eurjchem-1346	187	80	,	,	PUNCT
eurjchem-1346	187	81	exchanged	exchange	VERB
eurjchem-1346	187	82	with	with	ADP
eurjchem-1346	187	83	d2o	d2o	NOUN
eurjchem-1346	187	84	)	)	PUNCT
eurjchem-1346	187	85	,	,	PUNCT
eurjchem-1346	187	86	11.50	11.50	NUM
eurjchem-1346	187	87	(	(	PUNCT
eurjchem-1346	187	88	s	s	PROPN
eurjchem-1346	187	89	,	,	PUNCT
eurjchem-1346	187	90	1h	1h	NUM
eurjchem-1346	187	91	,	,	PUNCT
eurjchem-1346	187	92	nh	nh	PROPN
eurjchem-1346	187	93	,	,	PUNCT
eurjchem-1346	187	94	exchanged	exchange	VERB
eurjchem-1346	187	95	with	with	ADP
eurjchem-1346	187	96	d2o	d2o	NOUN
eurjchem-1346	187	97	)	)	PUNCT
eurjchem-1346	187	98	.	.	PUNCT
eurjchem-1346	188	1	anal	anal	PROPN
eurjchem-1346	188	2	.	.	PUNCT
eurjchem-1346	188	3	calcd	calcd	NOUN
eurjchem-1346	188	4	.	.	PUNCT
eurjchem-1346	189	1	for	for	ADP
eurjchem-1346	189	2	c8h9n5o	c8h9n5o	NOUN
eurjchem-1346	189	3	:	:	PUNCT
eurjchem-1346	189	4	c	c	X
eurjchem-1346	189	5	,	,	PUNCT
eurjchem-1346	189	6	50.26	50.26	NUM
eurjchem-1346	189	7	;	;	PUNCT
eurjchem-1346	189	8	h	h	X
eurjchem-1346	189	9	,	,	PUNCT
eurjchem-1346	189	10	4.74	4.74	NUM
eurjchem-1346	189	11	;	;	PUNCT
eurjchem-1346	189	12	n	n	CCONJ
eurjchem-1346	189	13	,	,	PUNCT
eurjchem-1346	189	14	36.63	36.63	NUM
eurjchem-1346	189	15	.	.	PUNCT
eurjchem-1346	189	16	found	find	VERB
eurjchem-1346	189	17	:	:	PUNCT
eurjchem-1346	190	1	c	c	X
eurjchem-1346	190	2	,	,	PUNCT
eurjchem-1346	190	3	50.41	50.41	NUM
eurjchem-1346	190	4	;	;	PUNCT
eurjchem-1346	190	5	h	h	NOUN
eurjchem-1346	190	6	,	,	PUNCT
eurjchem-1346	190	7	4.73	4.73	NUM
eurjchem-1346	190	8	;	;	PUNCT
eurjchem-1346	190	9	n	n	CCONJ
eurjchem-1346	190	10	,	,	PUNCT
eurjchem-1346	190	11	37.01	37.01	NUM
eurjchem-1346	190	12	%	%	NOUN
eurjchem-1346	190	13	.	.	PUNCT
eurjchem-1346	191	1	2.1.5	2.1.5	NUM
eurjchem-1346	191	2	.	.	PUNCT
eurjchem-1346	191	3	general	general	ADJ
eurjchem-1346	191	4	procedure	procedure	NOUN
eurjchem-1346	191	5	for	for	ADP
eurjchem-1346	191	6	synthesis	synthesis	NOUN
eurjchem-1346	191	7	of	of	ADP
eurjchem-1346	191	8	3‐(2‐(un)substitu‐	3‐(2‐(un)substitu‐	NUM
eurjchem-1346	191	9	ted	te	VERB
eurjchem-1346	191	10	benzylidene)hydrazinomethylpyrido[2,3‐b]pyrazin‐	benzylidene)hydrazinomethylpyrido[2,3‐b]pyrazin‐	PROPN
eurjchem-1346	191	11	2(1h)‐ones	2(1h)‐ones	NUM
eurjchem-1346	191	12	(	(	PUNCT
eurjchem-1346	191	13	5a‐e	5a‐e	ADJ
eurjchem-1346	191	14	)	)	PUNCT
eurjchem-1346	191	15	appropriate	appropriate	ADJ
eurjchem-1346	191	16	aromatic	aromatic	ADJ
eurjchem-1346	191	17	aldehyde	aldehyde	NOUN
eurjchem-1346	191	18	or	or	CCONJ
eurjchem-1346	191	19	ketone	ketone	NOUN
eurjchem-1346	191	20	(	(	PUNCT
eurjchem-1346	191	21	0.01	0.01	NUM
eurjchem-1346	191	22	mol	mol	NOUN
eurjchem-1346	191	23	)	)	PUNCT
eurjchem-1346	191	24	was	be	AUX
eurjchem-1346	191	25	added	add	VERB
eurjchem-1346	191	26	to	to	ADP
eurjchem-1346	191	27	a	a	DET
eurjchem-1346	191	28	solution	solution	NOUN
eurjchem-1346	191	29	of	of	ADP
eurjchem-1346	191	30	compound	compound	NOUN
eurjchem-1346	191	31	4	4	NUM
eurjchem-1346	191	32	(	(	PUNCT
eurjchem-1346	191	33	1.91	1.91	NUM
eurjchem-1346	191	34	g	g	NOUN
eurjchem-1346	191	35	,	,	PUNCT
eurjchem-1346	191	36	0.01	0.01	NUM
eurjchem-1346	191	37	mol	mol	NOUN
eurjchem-1346	191	38	)	)	PUNCT
eurjchem-1346	191	39	in	in	ADP
eurjchem-1346	191	40	glacial	glacial	ADJ
eurjchem-1346	191	41	acetic	acetic	ADJ
eurjchem-1346	191	42	acid	acid	NOUN
eurjchem-1346	191	43	(	(	PUNCT
eurjchem-1346	191	44	10	10	NUM
eurjchem-1346	191	45	ml	ml	NOUN
eurjchem-1346	191	46	)	)	PUNCT
eurjchem-1346	191	47	and	and	CCONJ
eurjchem-1346	191	48	refluxed	refluxe	VERB
eurjchem-1346	191	49	for	for	ADP
eurjchem-1346	191	50	8	8	NUM
eurjchem-1346	191	51	h.	h.	NOUN
eurjchem-1346	191	52	the	the	DET
eurjchem-1346	191	53	mixture	mixture	NOUN
eurjchem-1346	191	54	was	be	AUX
eurjchem-1346	191	55	allowed	allow	VERB
eurjchem-1346	191	56	to	to	PART
eurjchem-1346	191	57	cool	cool	VERB
eurjchem-1346	191	58	then	then	ADV
eurjchem-1346	191	59	poured	pour	VERB
eurjchem-1346	191	60	onto	onto	ADP
eurjchem-1346	191	61	crushed	crushed	ADJ
eurjchem-1346	191	62	ice	ice	NOUN
eurjchem-1346	191	63	(	(	PUNCT
eurjchem-1346	191	64	30	30	NUM
eurjchem-1346	191	65	g	g	NOUN
eurjchem-1346	191	66	)	)	PUNCT
eurjchem-1346	191	67	.	.	PUNCT
eurjchem-1346	192	1	the	the	DET
eurjchem-1346	192	2	precipitate	precipitate	NOUN
eurjchem-1346	192	3	was	be	AUX
eurjchem-1346	192	4	filtered	filter	VERB
eurjchem-1346	192	5	,	,	PUNCT
eurjchem-1346	192	6	washed	wash	VERB
eurjchem-1346	192	7	with	with	ADP
eurjchem-1346	192	8	water	water	NOUN
eurjchem-1346	192	9	(	(	PUNCT
eurjchem-1346	192	10	5	5	NUM
eurjchem-1346	192	11	ml	ml	NOUN
eurjchem-1346	192	12	)	)	PUNCT
eurjchem-1346	192	13	and	and	CCONJ
eurjchem-1346	192	14	dried	dry	VERB
eurjchem-1346	192	15	.	.	PUNCT
eurjchem-1346	193	1	the	the	DET
eurjchem-1346	193	2	crude	crude	ADJ
eurjchem-1346	193	3	product	product	NOUN
eurjchem-1346	193	4	was	be	AUX
eurjchem-1346	193	5	crystallized	crystallize	VERB
eurjchem-1346	193	6	from	from	ADP
eurjchem-1346	193	7	ethanol	ethanol	NOUN
eurjchem-1346	193	8	(	(	PUNCT
eurjchem-1346	193	9	scheme	scheme	NOUN
eurjchem-1346	193	10	1	1	NUM
eurjchem-1346	193	11	)	)	PUNCT
eurjchem-1346	193	12	.	.	PUNCT
eurjchem-1346	194	1	3‐(2‐benzylidene)hydrazinomethylpyrido[2	3‐(2‐benzylidene)hydrazinomethylpyrido[2	NUM
eurjchem-1346	194	2	,	,	PUNCT
eurjchem-1346	194	3	3‐b]pyrazin‐2	3‐b]pyrazin‐2	NUM
eurjchem-1346	194	4	(	(	PUNCT
eurjchem-1346	194	5	1h)‐one	1h)‐one	NUM
eurjchem-1346	194	6	(	(	PUNCT
eurjchem-1346	194	7	5a	5a	NUM
eurjchem-1346	194	8	):	):	PUNCT
eurjchem-1346	194	9	yield	yield	NOUN
eurjchem-1346	194	10	:	:	PUNCT
eurjchem-1346	194	11	62	62	NUM
eurjchem-1346	194	12	%	%	NOUN
eurjchem-1346	194	13	.	.	PUNCT
eurjchem-1346	195	1	m.p	m.p	PROPN
eurjchem-1346	195	2	.	.	PROPN
eurjchem-1346	195	3	:	:	PUNCT
eurjchem-1346	196	1	234‐236	234‐236	PROPN
eurjchem-1346	196	2	°	°	SYM
eurjchem-1346	196	3	c	c	PROPN
eurjchem-1346	196	4	.	.	PUNCT
eurjchem-1346	197	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	197	2	(	(	PUNCT
eurjchem-1346	197	3	kbr	kbr	PROPN
eurjchem-1346	197	4	,	,	PUNCT
eurjchem-1346	197	5			PROPN
eurjchem-1346	197	6	,	,	PUNCT
eurjchem-1346	197	7	cm‐	cm‐	NOUN
eurjchem-1346	197	8	1	1	NUM
eurjchem-1346	197	9	):	):	PUNCT
eurjchem-1346	197	10	3398	3398	NUM
eurjchem-1346	197	11	,	,	PUNCT
eurjchem-1346	197	12	3364	3364	NUM
eurjchem-1346	197	13	(	(	PUNCT
eurjchem-1346	197	14	2nh	2nh	PROPN
eurjchem-1346	197	15	)	)	PUNCT
eurjchem-1346	197	16	,	,	PUNCT
eurjchem-1346	197	17	3061	3061	NUM
eurjchem-1346	197	18	(	(	PUNCT
eurjchem-1346	197	19	ch	ch	PROPN
eurjchem-1346	197	20	ar	ar	PROPN
eurjchem-1346	197	21	)	)	PUNCT
eurjchem-1346	197	22	,	,	PUNCT
eurjchem-1346	197	23	2901	2901	NUM
eurjchem-1346	197	24	,	,	PUNCT
eurjchem-1346	197	25	2829	2829	NUM
eurjchem-1346	197	26	(	(	PUNCT
eurjchem-1346	197	27	ch	ch	NOUN
eurjchem-1346	197	28	aliph	aliph	PROPN
eurjchem-1346	197	29	)	)	PUNCT
eurjchem-1346	197	30	,	,	PUNCT
eurjchem-1346	197	31	1676	1676	NUM
eurjchem-1346	197	32	(	(	PUNCT
eurjchem-1346	197	33	c	c	NOUN
eurjchem-1346	197	34	=	=	NOUN
eurjchem-1346	197	35	o	o	NOUN
eurjchem-1346	197	36	)	)	PUNCT
eurjchem-1346	197	37	,	,	PUNCT
eurjchem-1346	197	38	1624	1624	NUM
eurjchem-1346	197	39	,	,	PUNCT
eurjchem-1346	197	40	1600	1600	NUM
eurjchem-1346	197	41	,	,	PUNCT
eurjchem-1346	197	42	1583	1583	NUM
eurjchem-1346	197	43	,	,	PUNCT
eurjchem-1346	197	44	1544	1544	NUM
eurjchem-1346	197	45	,	,	PUNCT
eurjchem-1346	197	46	1508	1508	NUM
eurjchem-1346	197	47	(	(	PUNCT
eurjchem-1346	197	48	c	c	NOUN
eurjchem-1346	197	49	=	=	SYM
eurjchem-1346	197	50	n	n	X
eurjchem-1346	197	51	,	,	PUNCT
eurjchem-1346	197	52	nh	nh	PROPN
eurjchem-1346	197	53	,	,	PUNCT
eurjchem-1346	197	54	c	c	X
eurjchem-1346	197	55	=	=	SYM
eurjchem-1346	197	56	c	c	NOUN
eurjchem-1346	197	57	)	)	PUNCT
eurjchem-1346	197	58	.	.	PUNCT
eurjchem-1346	198	1	1h	1h	NUM
eurjchem-1346	198	2	nmr	nmr	NOUN
eurjchem-1346	198	3	(	(	PUNCT
eurjchem-1346	198	4	400	400	NUM
eurjchem-1346	198	5	mhz	mhz	NOUN
eurjchem-1346	198	6	,	,	PUNCT
eurjchem-1346	198	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	198	8	,	,	PUNCT
eurjchem-1346	198	9	δ	δ	PROPN
eurjchem-1346	198	10	,	,	PUNCT
eurjchem-1346	198	11	ppm	ppm	NUM
eurjchem-1346	198	12	):	):	PUNCT
eurjchem-1346	198	13	2.32	2.32	NUM
eurjchem-1346	198	14	(	(	PUNCT
eurjchem-1346	198	15	s	s	PROPN
eurjchem-1346	198	16	,	,	PUNCT
eurjchem-1346	198	17	2h	2h	NUM
eurjchem-1346	198	18	,	,	PUNCT
eurjchem-1346	198	19	ch2	ch2	PROPN
eurjchem-1346	198	20	)	)	PUNCT
eurjchem-1346	198	21	,	,	PUNCT
eurjchem-1346	198	22	7.21	7.21	NUM
eurjchem-1346	198	23	(	(	PUNCT
eurjchem-1346	198	24	d	d	PROPN
eurjchem-1346	198	25	,	,	PUNCT
eurjchem-1346	198	26	j	j	PROPN
eurjchem-1346	198	27	=	=	SYM
eurjchem-1346	198	28	7.2	7.2	NUM
eurjchem-1346	198	29	hz	hz	NOUN
eurjchem-1346	198	30	,	,	PUNCT
eurjchem-1346	198	31	1h	1h	NUM
eurjchem-1346	198	32	,	,	PUNCT
eurjchem-1346	198	33	h‐8	h‐8	PROPN
eurjchem-1346	198	34	ar	ar	PROPN
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eurjchem-1346	198	51	,	,	PUNCT
eurjchem-1346	198	52	1h	1h	NUM
eurjchem-1346	198	53	,	,	PUNCT
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eurjchem-1346	198	55	ar	ar	PROPN
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eurjchem-1346	198	57	,	,	PUNCT
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eurjchem-1346	198	60	d	d	PROPN
eurjchem-1346	198	61	,	,	PUNCT
eurjchem-1346	198	62	j	j	PROPN
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eurjchem-1346	199	11	,	,	PUNCT
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eurjchem-1346	199	22	,	,	PUNCT
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eurjchem-1346	199	32	1h	1h	NUM
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eurjchem-1346	199	35	)	)	PUNCT
eurjchem-1346	199	36	,	,	PUNCT
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eurjchem-1346	199	49	,	,	PUNCT
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eurjchem-1346	199	54	1h	1h	NUM
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eurjchem-1346	199	57	,	,	PUNCT
eurjchem-1346	199	58	exchanged	exchange	VERB
eurjchem-1346	199	59	with	with	ADP
eurjchem-1346	199	60	d2o	d2o	NOUN
eurjchem-1346	199	61	)	)	PUNCT
eurjchem-1346	199	62	.	.	PUNCT
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eurjchem-1346	201	4	c	c	X
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eurjchem-1346	201	9	,	,	PUNCT
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eurjchem-1346	201	13	,	,	PUNCT
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eurjchem-1346	202	2	,	,	PUNCT
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eurjchem-1346	202	4	;	;	PUNCT
eurjchem-1346	202	5	h	h	NOUN
eurjchem-1346	202	6	,	,	PUNCT
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eurjchem-1346	202	13	.	.	PUNCT
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eurjchem-1346	203	8	):	):	PUNCT
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eurjchem-1346	206	2	(	(	PUNCT
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eurjchem-1346	206	38	,	,	PUNCT
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eurjchem-1346	206	42	,	,	PUNCT
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eurjchem-1346	206	44	,	,	PUNCT
eurjchem-1346	206	45	1521	1521	NUM
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eurjchem-1346	206	50	,	,	PUNCT
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eurjchem-1346	206	52	,	,	PUNCT
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eurjchem-1346	206	54	=	=	SYM
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eurjchem-1346	206	57	.	.	PUNCT
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eurjchem-1346	207	3	(	(	PUNCT
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eurjchem-1346	207	21	,	,	PUNCT
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eurjchem-1346	207	30	,	,	PUNCT
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eurjchem-1346	208	12	,	,	PUNCT
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eurjchem-1346	208	15	t	t	PROPN
eurjchem-1346	208	16	,	,	PUNCT
eurjchem-1346	208	17	1h	1h	NUM
eurjchem-1346	208	18	,	,	PUNCT
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eurjchem-1346	208	20	)	)	PUNCT
eurjchem-1346	208	21	,	,	PUNCT
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eurjchem-1346	208	23	(	(	PUNCT
eurjchem-1346	208	24	d	d	PROPN
eurjchem-1346	208	25	,	,	PUNCT
eurjchem-1346	208	26	j	j	PROPN
eurjchem-1346	208	27	=	=	SYM
eurjchem-1346	208	28	7.0	7.0	NUM
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eurjchem-1346	208	30	,	,	PUNCT
eurjchem-1346	208	31	2h	2h	NUM
eurjchem-1346	208	32	,	,	PUNCT
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eurjchem-1346	208	34	’	'	PUNCT
eurjchem-1346	208	35	ar	ar	NOUN
eurjchem-1346	208	36	)	)	PUNCT
eurjchem-1346	208	37	,	,	PUNCT
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eurjchem-1346	208	39	(	(	PUNCT
eurjchem-1346	208	40	s	s	PROPN
eurjchem-1346	208	41	,	,	PUNCT
eurjchem-1346	208	42	1h	1h	NUM
eurjchem-1346	208	43	,	,	PUNCT
eurjchem-1346	208	44	n	n	CCONJ
eurjchem-1346	208	45	=	=	SYM
eurjchem-1346	208	46	ch	ch	NOUN
eurjchem-1346	208	47	)	)	PUNCT
eurjchem-1346	208	48	,	,	PUNCT
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eurjchem-1346	208	50	(	(	PUNCT
eurjchem-1346	208	51	d	d	PROPN
eurjchem-1346	208	52	,	,	PUNCT
eurjchem-1346	208	53	j	j	PROPN
eurjchem-1346	208	54	=	=	SYM
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eurjchem-1346	208	57	,	,	PUNCT
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eurjchem-1346	208	59	,	,	PUNCT
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eurjchem-1346	208	61	ar	ar	NOUN
eurjchem-1346	208	62	)	)	PUNCT
eurjchem-1346	208	63	,	,	PUNCT
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eurjchem-1346	208	65	(	(	PUNCT
eurjchem-1346	208	66	s	s	PROPN
eurjchem-1346	208	67	,	,	PUNCT
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eurjchem-1346	208	69	,	,	PUNCT
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eurjchem-1346	208	73	with	with	ADP
eurjchem-1346	208	74	d2o	d2o	NOUN
eurjchem-1346	208	75	)	)	PUNCT
eurjchem-1346	208	76	,	,	PUNCT
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eurjchem-1346	208	79	s	s	PROPN
eurjchem-1346	208	80	,	,	PUNCT
eurjchem-1346	208	81	1h	1h	NUM
eurjchem-1346	208	82	,	,	PUNCT
eurjchem-1346	208	83	nh	nh	PROPN
eurjchem-1346	208	84	,	,	PUNCT
eurjchem-1346	208	85	exchanged	exchange	VERB
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eurjchem-1346	208	87	d2o	d2o	NOUN
eurjchem-1346	208	88	)	)	PUNCT
eurjchem-1346	208	89	.	.	PUNCT
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eurjchem-1346	209	2	(	(	PUNCT
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eurjchem-1346	209	4	,	,	PUNCT
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eurjchem-1346	209	7	z	z	PROPN
eurjchem-1346	209	8	(	(	PUNCT
eurjchem-1346	209	9	%	%	NOUN
eurjchem-1346	209	10	)	)	PUNCT
eurjchem-1346	209	11	):	):	PUNCT
eurjchem-1346	209	12	313	313	NUM
eurjchem-1346	209	13	(	(	PUNCT
eurjchem-1346	209	14	m+	m+	NUM
eurjchem-1346	209	15	,	,	PUNCT
eurjchem-1346	209	16	2.63	2.63	NUM
eurjchem-1346	209	17	)	)	PUNCT
eurjchem-1346	209	18	,	,	PUNCT
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eurjchem-1346	209	20	(	(	PUNCT
eurjchem-1346	209	21	m++2	m++2	PROPN
eurjchem-1346	209	22	,	,	PUNCT
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eurjchem-1346	209	24	)	)	PUNCT
eurjchem-1346	209	25	.	.	PUNCT
eurjchem-1346	210	1	anal	anal	PROPN
eurjchem-1346	210	2	.	.	PUNCT
eurjchem-1346	210	3	calcd	calcd	NOUN
eurjchem-1346	210	4	.	.	PUNCT
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eurjchem-1346	211	2	c15h12cln5o	c15h12cln5o	NOUN
eurjchem-1346	211	3	:	:	PUNCT
eurjchem-1346	211	4	c	c	X
eurjchem-1346	211	5	,	,	PUNCT
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eurjchem-1346	211	7	;	;	PUNCT
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eurjchem-1346	211	9	,	,	PUNCT
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eurjchem-1346	211	11	;	;	PUNCT
eurjchem-1346	211	12	n	n	CCONJ
eurjchem-1346	211	13	,	,	PUNCT
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eurjchem-1346	211	15	.	.	PUNCT
eurjchem-1346	211	16	found	find	VERB
eurjchem-1346	211	17	:	:	PUNCT
eurjchem-1346	212	1	c	c	X
eurjchem-1346	212	2	,	,	PUNCT
eurjchem-1346	212	3	57.52	57.52	NUM
eurjchem-1346	212	4	;	;	PUNCT
eurjchem-1346	212	5	h	h	NOUN
eurjchem-1346	212	6	,	,	PUNCT
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eurjchem-1346	212	8	;	;	PUNCT
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eurjchem-1346	212	10	,	,	PUNCT
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eurjchem-1346	212	13	.	.	PUNCT
eurjchem-1346	213	1	3‐[2‐(4‐nitrobenzylidene)]hydrazinomethylpyrido[2	3‐[2‐(4‐nitrobenzylidene)]hydrazinomethylpyrido[2	NUM
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eurjchem-1346	213	4	]	]	PUNCT
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eurjchem-1346	213	6	(	(	PUNCT
eurjchem-1346	213	7	5c	5c	NUM
eurjchem-1346	213	8	):	):	PUNCT
eurjchem-1346	213	9	yield	yield	NOUN
eurjchem-1346	213	10	:	:	PUNCT
eurjchem-1346	213	11	70	70	NUM
eurjchem-1346	213	12	%	%	NOUN
eurjchem-1346	213	13	.	.	PUNCT
eurjchem-1346	214	1	m.p	m.p	PROPN
eurjchem-1346	214	2	.	.	PROPN
eurjchem-1346	214	3	:	:	PUNCT
eurjchem-1346	215	1	238‐240	238‐240	NUM
eurjchem-1346	215	2	°	°	PROPN
eurjchem-1346	215	3	c	c	PROPN
eurjchem-1346	215	4	.	.	PUNCT
eurjchem-1346	215	5	ft‐ir	ft‐ir	NOUN
eurjchem-1346	215	6	(	(	PUNCT
eurjchem-1346	215	7	kbr	kbr	PROPN
eurjchem-1346	215	8	,	,	PUNCT
eurjchem-1346	215	9			PROPN
eurjchem-1346	215	10	,	,	PUNCT
eurjchem-1346	215	11	cm‐1	cm‐1	PROPN
eurjchem-1346	215	12	):	):	PUNCT
eurjchem-1346	215	13	3444	3444	NUM
eurjchem-1346	215	14	,	,	PUNCT
eurjchem-1346	215	15	3365	3365	NUM
eurjchem-1346	215	16	(	(	PUNCT
eurjchem-1346	215	17	2nh	2nh	NOUN
eurjchem-1346	215	18	)	)	PUNCT
eurjchem-1346	215	19	,	,	PUNCT
eurjchem-1346	215	20	3021	3021	NUM
eurjchem-1346	215	21	(	(	PUNCT
eurjchem-1346	215	22	ch	ch	PROPN
eurjchem-1346	215	23	ar	ar	PROPN
eurjchem-1346	215	24	)	)	PUNCT
eurjchem-1346	215	25	,	,	PUNCT
eurjchem-1346	215	26	2926	2926	NUM
eurjchem-1346	215	27	,	,	PUNCT
eurjchem-1346	215	28	2850	2850	NUM
eurjchem-1346	215	29	(	(	PUNCT
eurjchem-1346	215	30	ch	ch	NOUN
eurjchem-1346	215	31	aliph	aliph	PROPN
eurjchem-1346	215	32	)	)	PUNCT
eurjchem-1346	215	33	,	,	PUNCT
eurjchem-1346	215	34	1677	1677	NUM
eurjchem-1346	215	35	(	(	PUNCT
eurjchem-1346	215	36	c	c	NOUN
eurjchem-1346	215	37	=	=	NOUN
eurjchem-1346	215	38	o	o	NOUN
eurjchem-1346	215	39	)	)	PUNCT
eurjchem-1346	215	40	,	,	PUNCT
eurjchem-1346	215	41	1653	1653	NUM
eurjchem-1346	215	42	,	,	PUNCT
eurjchem-1346	215	43	1614	1614	NUM
eurjchem-1346	215	44	,	,	PUNCT
eurjchem-1346	215	45	1597	1597	NUM
eurjchem-1346	215	46	,	,	PUNCT
eurjchem-1346	215	47	1558	1558	NUM
eurjchem-1346	215	48	(	(	PUNCT
eurjchem-1346	215	49	c	c	NOUN
eurjchem-1346	215	50	=	=	SYM
eurjchem-1346	215	51	n	n	X
eurjchem-1346	215	52	,	,	PUNCT
eurjchem-1346	215	53	nh	nh	PROPN
eurjchem-1346	215	54	,	,	PUNCT
eurjchem-1346	215	55	c	c	X
eurjchem-1346	215	56	=	=	SYM
eurjchem-1346	215	57	c	c	NOUN
eurjchem-1346	215	58	)	)	PUNCT
eurjchem-1346	215	59	,	,	PUNCT
eurjchem-1346	215	60	1519	1519	NUM
eurjchem-1346	215	61	,	,	PUNCT
eurjchem-1346	215	62	1344	1344	NUM
eurjchem-1346	215	63	(	(	PUNCT
eurjchem-1346	215	64	no2	no2	NOUN
eurjchem-1346	215	65	)	)	PUNCT
eurjchem-1346	215	66	.	.	PUNCT
eurjchem-1346	216	1	1h	1h	NUM
eurjchem-1346	216	2	nmr	nmr	NOUN
eurjchem-1346	216	3	(	(	PUNCT
eurjchem-1346	216	4	400	400	NUM
eurjchem-1346	216	5	mhz	mhz	NOUN
eurjchem-1346	216	6	,	,	PUNCT
eurjchem-1346	216	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	216	8	,	,	PUNCT
eurjchem-1346	216	9	δ	δ	PROPN
eurjchem-1346	216	10	,	,	PUNCT
eurjchem-1346	216	11	ppm	ppm	NUM
eurjchem-1346	216	12	):	):	PUNCT
eurjchem-1346	216	13	2.33	2.33	NUM
eurjchem-1346	216	14	(	(	PUNCT
eurjchem-1346	216	15	s	s	PROPN
eurjchem-1346	216	16	,	,	PUNCT
eurjchem-1346	216	17	2h	2h	NUM
eurjchem-1346	216	18	,	,	PUNCT
eurjchem-1346	216	19	ch2	ch2	PROPN
eurjchem-1346	216	20	)	)	PUNCT
eurjchem-1346	216	21	,	,	PUNCT
eurjchem-1346	216	22	7.21	7.21	NUM
eurjchem-1346	216	23	(	(	PUNCT
eurjchem-1346	216	24	d	d	PROPN
eurjchem-1346	216	25	,	,	PUNCT
eurjchem-1346	216	26	j	j	PROPN
eurjchem-1346	216	27	=	=	SYM
eurjchem-1346	216	28	6.4	6.4	NUM
eurjchem-1346	216	29	hz	hz	NOUN
eurjchem-1346	216	30	,	,	PUNCT
eurjchem-1346	216	31	1h	1h	NUM
eurjchem-1346	216	32	,	,	PUNCT
eurjchem-1346	216	33	h‐8ar	h‐8ar	NOUN
eurjchem-1346	216	34	)	)	PUNCT
eurjchem-1346	216	35	,	,	PUNCT
eurjchem-1346	216	36	7.66	7.66	NUM
eurjchem-1346	216	37	(	(	PUNCT
eurjchem-1346	216	38	t	t	PROPN
eurjchem-1346	216	39	,	,	PUNCT
eurjchem-1346	216	40	1h	1h	NUM
eurjchem-1346	216	41	,	,	PUNCT
eurjchem-1346	216	42	h‐	h‐	PROPN
eurjchem-1346	216	43	7ar	7ar	NOUN
eurjchem-1346	216	44	)	)	PUNCT
eurjchem-1346	216	45	,	,	PUNCT
eurjchem-1346	216	46	7.91‐8.10	7.91‐8.10	NUM
eurjchem-1346	216	47	(	(	PUNCT
eurjchem-1346	216	48	m	m	PROPN
eurjchem-1346	216	49	,	,	PUNCT
eurjchem-1346	216	50	4h	4h	NUM
eurjchem-1346	216	51	,	,	PUNCT
eurjchem-1346	216	52	h‐2	h‐2	X
eurjchem-1346	216	53	’	'	PUNCT
eurjchem-1346	216	54	,	,	PUNCT
eurjchem-1346	216	55	3	3	NUM
eurjchem-1346	216	56	’	'	PUNCT
eurjchem-1346	216	57	,	,	PUNCT
eurjchem-1346	216	58	5	5	NUM
eurjchem-1346	216	59	’	'	PUNCT
eurjchem-1346	216	60	,	,	PUNCT
eurjchem-1346	216	61	6	6	NUM
eurjchem-1346	216	62	’	'	PUNCT
eurjchem-1346	216	63	ar	ar	NOUN
eurjchem-1346	216	64	)	)	PUNCT
eurjchem-1346	216	65	,	,	PUNCT
eurjchem-1346	216	66	8.19	8.19	NUM
eurjchem-1346	216	67	(	(	PUNCT
eurjchem-1346	216	68	s	s	PROPN
eurjchem-1346	216	69	,	,	PUNCT
eurjchem-1346	216	70	1h	1h	NUM
eurjchem-1346	216	71	,	,	PUNCT
eurjchem-1346	216	72	n	n	CCONJ
eurjchem-1346	216	73	=	=	SYM
eurjchem-1346	216	74	ch	ch	NOUN
eurjchem-1346	216	75	)	)	PUNCT
eurjchem-1346	216	76	,	,	PUNCT
eurjchem-1346	216	77	8.23	8.23	NUM
eurjchem-1346	216	78	(	(	PUNCT
eurjchem-1346	216	79	d	d	PROPN
eurjchem-1346	216	80	,	,	PUNCT
eurjchem-1346	216	81	j	j	PROPN
eurjchem-1346	216	82	=	=	SYM
eurjchem-1346	216	83	7.2	7.2	NUM
eurjchem-1346	216	84	hz	hz	NOUN
eurjchem-1346	216	85	,	,	PUNCT
eurjchem-1346	216	86	1h	1h	NUM
eurjchem-1346	216	87	,	,	PUNCT
eurjchem-1346	216	88	h‐6ar	h‐6ar	NOUN
eurjchem-1346	216	89	)	)	PUNCT
eurjchem-1346	216	90	,	,	PUNCT
eurjchem-1346	216	91	11.32	11.32	NUM
eurjchem-1346	216	92	(	(	PUNCT
eurjchem-1346	216	93	s	s	PROPN
eurjchem-1346	216	94	,	,	PUNCT
eurjchem-1346	216	95	1h	1h	NUM
eurjchem-1346	216	96	,	,	PUNCT
eurjchem-1346	216	97	nh	nh	PROPN
eurjchem-1346	216	98	,	,	PUNCT
eurjchem-1346	216	99	exchanged	exchange	VERB
eurjchem-1346	216	100	with	with	ADP
eurjchem-1346	216	101	d2o	d2o	NOUN
eurjchem-1346	216	102	)	)	PUNCT
eurjchem-1346	216	103	,	,	PUNCT
eurjchem-1346	216	104	11.50	11.50	NUM
eurjchem-1346	216	105	(	(	PUNCT
eurjchem-1346	216	106	s	s	PROPN
eurjchem-1346	216	107	,	,	PUNCT
eurjchem-1346	216	108	1h	1h	NUM
eurjchem-1346	216	109	,	,	PUNCT
eurjchem-1346	216	110	nh	nh	PROPN
eurjchem-1346	216	111	,	,	PUNCT
eurjchem-1346	216	112	exchanged	exchange	VERB
eurjchem-1346	216	113	with	with	ADP
eurjchem-1346	216	114	d2o	d2o	NOUN
eurjchem-1346	216	115	)	)	PUNCT
eurjchem-1346	216	116	.	.	PUNCT
eurjchem-1346	217	1	anal	anal	PROPN
eurjchem-1346	217	2	.	.	PUNCT
eurjchem-1346	217	3	calcd	calcd	NOUN
eurjchem-1346	217	4	.	.	PUNCT
eurjchem-1346	218	1	for	for	ADP
eurjchem-1346	218	2	c15h12n6o3	c15h12n6o3	PROPN
eurjchem-1346	218	3	:	:	PUNCT
eurjchem-1346	218	4	c	c	X
eurjchem-1346	218	5	,	,	PUNCT
eurjchem-1346	218	6	55.55	55.55	NUM
eurjchem-1346	218	7	;	;	PUNCT
eurjchem-1346	218	8	h	h	NOUN
eurjchem-1346	218	9	,	,	PUNCT
eurjchem-1346	218	10	3.73	3.73	NUM
eurjchem-1346	218	11	;	;	PUNCT
eurjchem-1346	218	12	n	n	CCONJ
eurjchem-1346	218	13	,	,	PUNCT
eurjchem-1346	218	14	25.91	25.91	NUM
eurjchem-1346	218	15	.	.	PUNCT
eurjchem-1346	218	16	found	find	VERB
eurjchem-1346	218	17	:	:	PUNCT
eurjchem-1346	219	1	c	c	X
eurjchem-1346	219	2	,	,	PUNCT
eurjchem-1346	219	3	55.74	55.74	NUM
eurjchem-1346	219	4	;	;	PUNCT
eurjchem-1346	219	5	h	h	NOUN
eurjchem-1346	219	6	,	,	PUNCT
eurjchem-1346	219	7	3.74	3.74	NUM
eurjchem-1346	219	8	;	;	PUNCT
eurjchem-1346	219	9	n	n	CCONJ
eurjchem-1346	219	10	,	,	PUNCT
eurjchem-1346	219	11	26.07	26.07	NUM
eurjchem-1346	219	12	%	%	NOUN
eurjchem-1346	219	13	.	.	PUNCT
eurjchem-1346	220	1	3‐[2‐(4‐methoxybenzylidene)]hydrazinomethylpyrido[2	3‐[2‐(4‐methoxybenzylidene)]hydrazinomethylpyrido[2	NUM
eurjchem-1346	220	2	,	,	PUNCT
eurjchem-1346	220	3	3‐	3‐	NUM
eurjchem-1346	220	4	b]pyrazin‐2(1h)‐one	b]pyrazin‐2(1h)‐one	NOUN
eurjchem-1346	220	5	(	(	PUNCT
eurjchem-1346	220	6	5d	5d	NUM
eurjchem-1346	220	7	):	):	PUNCT
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eurjchem-1346	220	9	:	:	PUNCT
eurjchem-1346	220	10	63	63	NUM
eurjchem-1346	220	11	%	%	NOUN
eurjchem-1346	220	12	.	.	PUNCT
eurjchem-1346	221	1	m.p	m.p	PROPN
eurjchem-1346	221	2	.	.	PROPN
eurjchem-1346	221	3	:	:	PUNCT
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eurjchem-1346	222	4	.	.	PUNCT
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eurjchem-1346	223	2	(	(	PUNCT
eurjchem-1346	223	3	kbr	kbr	PROPN
eurjchem-1346	223	4	,	,	PUNCT
eurjchem-1346	223	5			PROPN
eurjchem-1346	223	6	,	,	PUNCT
eurjchem-1346	223	7	cm‐1	cm‐1	PROPN
eurjchem-1346	223	8	):	):	PUNCT
eurjchem-1346	223	9	3417	3417	NUM
eurjchem-1346	223	10	,	,	PUNCT
eurjchem-1346	223	11	3392	3392	NUM
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eurjchem-1346	223	13	2nh	2nh	NOUN
eurjchem-1346	223	14	)	)	PUNCT
eurjchem-1346	223	15	,	,	PUNCT
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eurjchem-1346	223	17	(	(	PUNCT
eurjchem-1346	223	18	ch	ch	PROPN
eurjchem-1346	223	19	ar	ar	PROPN
eurjchem-1346	223	20	)	)	PUNCT
eurjchem-1346	223	21	,	,	PUNCT
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eurjchem-1346	223	23	,	,	PUNCT
eurjchem-1346	223	24	2837	2837	NUM
eurjchem-1346	223	25	(	(	PUNCT
eurjchem-1346	223	26	ch	ch	NOUN
eurjchem-1346	223	27	aliph	aliph	PROPN
eurjchem-1346	223	28	)	)	PUNCT
eurjchem-1346	223	29	,	,	PUNCT
eurjchem-1346	223	30	1670	1670	NUM
eurjchem-1346	223	31	(	(	PUNCT
eurjchem-1346	223	32	c	c	NOUN
eurjchem-1346	223	33	=	=	NOUN
eurjchem-1346	223	34	o	o	NOUN
eurjchem-1346	223	35	)	)	PUNCT
eurjchem-1346	223	36	,	,	PUNCT
eurjchem-1346	223	37	1598	1598	NUM
eurjchem-1346	223	38	,	,	PUNCT
eurjchem-1346	223	39	1575	1575	NUM
eurjchem-1346	223	40	,	,	PUNCT
eurjchem-1346	223	41	1558	1558	NUM
eurjchem-1346	223	42	,	,	PUNCT
eurjchem-1346	223	43	1541	1541	NUM
eurjchem-1346	223	44	,	,	PUNCT
eurjchem-1346	223	45	1508	1508	NUM
eurjchem-1346	223	46	(	(	PUNCT
eurjchem-1346	223	47	c	c	NOUN
eurjchem-1346	223	48	=	=	SYM
eurjchem-1346	223	49	n	n	X
eurjchem-1346	223	50	,	,	PUNCT
eurjchem-1346	223	51	nh	nh	PROPN
eurjchem-1346	223	52	,	,	PUNCT
eurjchem-1346	223	53	c	c	X
eurjchem-1346	223	54	=	=	SYM
eurjchem-1346	223	55	c	c	NOUN
eurjchem-1346	223	56	)	)	PUNCT
eurjchem-1346	223	57	.	.	PUNCT
eurjchem-1346	224	1	1h	1h	NUM
eurjchem-1346	224	2	nmr	nmr	NOUN
eurjchem-1346	224	3	(	(	PUNCT
eurjchem-1346	224	4	400	400	NUM
eurjchem-1346	224	5	mhz	mhz	NOUN
eurjchem-1346	224	6	,	,	PUNCT
eurjchem-1346	224	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	224	8	,	,	PUNCT
eurjchem-1346	224	9	δ	δ	PROPN
eurjchem-1346	224	10	,	,	PUNCT
eurjchem-1346	224	11	ppm	ppm	NUM
eurjchem-1346	224	12	):	):	PUNCT
eurjchem-1346	224	13	2.12	2.12	NUM
eurjchem-1346	224	14	(	(	PUNCT
eurjchem-1346	224	15	s	s	PROPN
eurjchem-1346	224	16	,	,	PUNCT
eurjchem-1346	224	17	2h	2h	NUM
eurjchem-1346	224	18	,	,	PUNCT
eurjchem-1346	224	19	ch2	ch2	PROPN
eurjchem-1346	224	20	)	)	PUNCT
eurjchem-1346	224	21	,	,	PUNCT
eurjchem-1346	224	22	3.52	3.52	NUM
eurjchem-1346	224	23	(	(	PUNCT
eurjchem-1346	224	24	s	s	PROPN
eurjchem-1346	224	25	,	,	PUNCT
eurjchem-1346	224	26	3h	3h	NUM
eurjchem-1346	224	27	,	,	PUNCT
eurjchem-1346	224	28	och3	och3	ADJ
eurjchem-1346	224	29	)	)	PUNCT
eurjchem-1346	224	30	,	,	PUNCT
eurjchem-1346	224	31	6.76	6.76	NUM
eurjchem-1346	224	32	(	(	PUNCT
eurjchem-1346	224	33	d	d	PROPN
eurjchem-1346	224	34	,	,	PUNCT
eurjchem-1346	224	35	j	j	PROPN
eurjchem-1346	224	36	=	=	PROPN
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eurjchem-1346	224	39	,	,	PUNCT
eurjchem-1346	224	40	2h	2h	NUM
eurjchem-1346	224	41	,	,	PUNCT
eurjchem-1346	224	42	h‐3’,5	h‐3’,5	NOUN
eurjchem-1346	224	43	’	'	PUNCT
eurjchem-1346	224	44	ar	ar	PROPN
eurjchem-1346	224	45	)	)	PUNCT
eurjchem-1346	224	46	,	,	PUNCT
eurjchem-1346	224	47	7.21	7.21	NUM
eurjchem-1346	224	48	(	(	PUNCT
eurjchem-1346	224	49	d	d	PROPN
eurjchem-1346	224	50	,	,	PUNCT
eurjchem-1346	224	51	j	j	PROPN
eurjchem-1346	224	52	=	=	SYM
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eurjchem-1346	224	54	hz	hz	NOUN
eurjchem-1346	224	55	,	,	PUNCT
eurjchem-1346	224	56	1h	1h	NUM
eurjchem-1346	224	57	,	,	PUNCT
eurjchem-1346	224	58	h‐8	h‐8	PROPN
eurjchem-1346	224	59	ar	ar	PROPN
eurjchem-1346	224	60	)	)	PUNCT
eurjchem-1346	224	61	,	,	PUNCT
eurjchem-1346	224	62	7.43	7.43	NUM
eurjchem-1346	224	63	(	(	PUNCT
eurjchem-1346	224	64	t	t	PROPN
eurjchem-1346	224	65	,	,	PUNCT
eurjchem-1346	224	66	1h	1h	NUM
eurjchem-1346	224	67	,	,	PUNCT
eurjchem-1346	224	68	h‐7	h‐7	PROPN
eurjchem-1346	224	69	ar	ar	PROPN
eurjchem-1346	224	70	)	)	PUNCT
eurjchem-1346	224	71	,	,	PUNCT
eurjchem-1346	224	72	7.66	7.66	NUM
eurjchem-1346	224	73	(	(	PUNCT
eurjchem-1346	224	74	d	d	PROPN
eurjchem-1346	224	75	,	,	PUNCT
eurjchem-1346	224	76	j	j	PROPN
eurjchem-1346	224	77	=	=	SYM
eurjchem-1346	224	78	7.4	7.4	NUM
eurjchem-1346	224	79	hz	hz	VERB
eurjchem-1346	224	80	,	,	PUNCT
eurjchem-1346	224	81	2h	2h	NUM
eurjchem-1346	224	82	,	,	PUNCT
eurjchem-1346	224	83	h‐2’,6	h‐2’,6	NUM
eurjchem-1346	224	84	’	'	PUNCT
eurjchem-1346	224	85	ar	ar	NOUN
eurjchem-1346	224	86	)	)	PUNCT
eurjchem-1346	224	87	,	,	PUNCT
eurjchem-1346	224	88	8.10	8.10	NUM
eurjchem-1346	224	89	(	(	PUNCT
eurjchem-1346	224	90	s	s	PROPN
eurjchem-1346	224	91	,	,	PUNCT
eurjchem-1346	224	92	1h	1h	NUM
eurjchem-1346	224	93	,	,	PUNCT
eurjchem-1346	224	94	n	n	CCONJ
eurjchem-1346	224	95	=	=	SYM
eurjchem-1346	224	96	ch	ch	NOUN
eurjchem-1346	224	97	)	)	PUNCT
eurjchem-1346	224	98	,	,	PUNCT
eurjchem-1346	224	99	8.22	8.22	NUM
eurjchem-1346	224	100	(	(	PUNCT
eurjchem-1346	224	101	d	d	PROPN
eurjchem-1346	224	102	,	,	PUNCT
eurjchem-1346	224	103	j	j	PROPN
eurjchem-1346	224	104	=	=	SYM
eurjchem-1346	224	105	7.6	7.6	NUM
eurjchem-1346	224	106	hz	hz	NOUN
eurjchem-1346	224	107	,	,	PUNCT
eurjchem-1346	224	108	1h	1h	NUM
eurjchem-1346	224	109	,	,	PUNCT
eurjchem-1346	224	110	h‐6ar	h‐6ar	NOUN
eurjchem-1346	224	111	)	)	PUNCT
eurjchem-1346	224	112	,	,	PUNCT
eurjchem-1346	224	113	11.30	11.30	NUM
eurjchem-1346	224	114	(	(	PUNCT
eurjchem-1346	224	115	s	s	PROPN
eurjchem-1346	224	116	,	,	PUNCT
eurjchem-1346	224	117	1h	1h	NUM
eurjchem-1346	224	118	,	,	PUNCT
eurjchem-1346	224	119	nh	nh	PROPN
eurjchem-1346	224	120	,	,	PUNCT
eurjchem-1346	224	121	exchanged	exchange	VERB
eurjchem-1346	224	122	with	with	ADP
eurjchem-1346	224	123	d2o	d2o	NOUN
eurjchem-1346	224	124	)	)	PUNCT
eurjchem-1346	224	125	,	,	PUNCT
eurjchem-1346	224	126	11.45	11.45	NUM
eurjchem-1346	224	127	(	(	PUNCT
eurjchem-1346	224	128	s	s	PROPN
eurjchem-1346	224	129	,	,	PUNCT
eurjchem-1346	224	130	1h	1h	NUM
eurjchem-1346	224	131	,	,	PUNCT
eurjchem-1346	224	132	nh	nh	PROPN
eurjchem-1346	224	133	,	,	PUNCT
eurjchem-1346	224	134	exchanged	exchange	VERB
eurjchem-1346	224	135	with	with	ADP
eurjchem-1346	224	136	d2o	d2o	NOUN
eurjchem-1346	224	137	)	)	PUNCT
eurjchem-1346	224	138	.	.	PUNCT
eurjchem-1346	225	1	anal	anal	PROPN
eurjchem-1346	225	2	.	.	PUNCT
eurjchem-1346	225	3	calcd	calcd	NOUN
eurjchem-1346	225	4	.	.	PUNCT
eurjchem-1346	226	1	for	for	ADP
eurjchem-1346	226	2	c16h15n5o2	c16h15n5o2	NOUN
eurjchem-1346	226	3	:	:	PUNCT
eurjchem-1346	226	4	c	c	X
eurjchem-1346	226	5	,	,	PUNCT
eurjchem-1346	226	6	62.13	62.13	NUM
eurjchem-1346	226	7	;	;	PUNCT
eurjchem-1346	226	8	h	h	X
eurjchem-1346	226	9	,	,	PUNCT
eurjchem-1346	226	10	4.89	4.89	NUM
eurjchem-1346	226	11	;	;	PUNCT
eurjchem-1346	226	12	n	n	CCONJ
eurjchem-1346	226	13	,	,	PUNCT
eurjchem-1346	226	14	22.64	22.64	NUM
eurjchem-1346	226	15	.	.	PUNCT
eurjchem-1346	226	16	found	find	VERB
eurjchem-1346	226	17	:	:	PUNCT
eurjchem-1346	227	1	c	c	X
eurjchem-1346	227	2	,	,	PUNCT
eurjchem-1346	227	3	62.26	62.26	NUM
eurjchem-1346	227	4	;	;	PUNCT
eurjchem-1346	227	5	h	h	X
eurjchem-1346	227	6	,	,	PUNCT
eurjchem-1346	227	7	4.87	4.87	NUM
eurjchem-1346	227	8	;	;	PUNCT
eurjchem-1346	227	9	n	n	CCONJ
eurjchem-1346	227	10	,	,	PUNCT
eurjchem-1346	227	11	22.72	22.72	NUM
eurjchem-1346	227	12	%	%	NOUN
eurjchem-1346	227	13	.	.	PUNCT
eurjchem-1346	228	1	3‐(2‐methyl‐2‐phenyl)hydrazinomethylpyrido[2	3‐(2‐methyl‐2‐phenyl)hydrazinomethylpyrido[2	NUM
eurjchem-1346	228	2	,	,	PUNCT
eurjchem-1346	228	3	3‐b]pyrazin	3‐b]pyrazin	NUM
eurjchem-1346	228	4	‐2(1h)‐one	‐2(1h)‐one	NOUN
eurjchem-1346	228	5	(	(	PUNCT
eurjchem-1346	228	6	5e	5e	NOUN
eurjchem-1346	228	7	):	):	PUNCT
eurjchem-1346	228	8	yield	yield	NOUN
eurjchem-1346	228	9	:	:	PUNCT
eurjchem-1346	228	10	69	69	NUM
eurjchem-1346	228	11	%	%	NOUN
eurjchem-1346	228	12	.	.	PUNCT
eurjchem-1346	229	1	m.p	m.p	PROPN
eurjchem-1346	229	2	.	.	PROPN
eurjchem-1346	229	3	:	:	PUNCT
eurjchem-1346	230	1	230‐233	230‐233	NUM
eurjchem-1346	230	2	°	°	ADP
eurjchem-1346	230	3	c	c	X
eurjchem-1346	230	4	.	.	PUNCT
eurjchem-1346	230	5	ft‐ir	ft‐ir	NOUN
eurjchem-1346	230	6	(	(	PUNCT
eurjchem-1346	230	7	kbr	kbr	PROPN
eurjchem-1346	230	8	,	,	PUNCT
eurjchem-1346	230	9			PROPN
eurjchem-1346	230	10	,	,	PUNCT
eurjchem-1346	230	11	cm‐1	cm‐1	PROPN
eurjchem-1346	230	12	):	):	PUNCT
eurjchem-1346	230	13	3446	3446	NUM
eurjchem-1346	230	14	,	,	PUNCT
eurjchem-1346	230	15	3363	3363	NUM
eurjchem-1346	230	16	(	(	PUNCT
eurjchem-1346	230	17	2nh	2nh	PROPN
eurjchem-1346	230	18	)	)	PUNCT
eurjchem-1346	230	19	,	,	PUNCT
eurjchem-1346	230	20	3032	3032	NUM
eurjchem-1346	230	21	(	(	PUNCT
eurjchem-1346	230	22	ch	ch	PROPN
eurjchem-1346	230	23	ar	ar	PROPN
eurjchem-1346	230	24	)	)	PUNCT
eurjchem-1346	230	25	,	,	PUNCT
eurjchem-1346	230	26	2929	2929	NUM
eurjchem-1346	230	27	,	,	PUNCT
eurjchem-1346	230	28	2856	2856	NUM
eurjchem-1346	230	29	(	(	PUNCT
eurjchem-1346	230	30	ch	ch	NOUN
eurjchem-1346	230	31	aliph	aliph	PROPN
eurjchem-1346	230	32	)	)	PUNCT
eurjchem-1346	230	33	,	,	PUNCT
eurjchem-1346	230	34	1670	1670	NUM
eurjchem-1346	230	35	(	(	PUNCT
eurjchem-1346	230	36	c	c	NOUN
eurjchem-1346	230	37	=	=	NOUN
eurjchem-1346	230	38	o	o	NOUN
eurjchem-1346	230	39	)	)	PUNCT
eurjchem-1346	230	40	,	,	PUNCT
eurjchem-1346	230	41	1645	1645	NUM
eurjchem-1346	230	42	,	,	PUNCT
eurjchem-1346	230	43	1616	1616	NUM
eurjchem-1346	230	44	,	,	PUNCT
eurjchem-1346	230	45	1570	1570	NUM
eurjchem-1346	230	46	,	,	PUNCT
eurjchem-1346	230	47	1558	1558	NUM
eurjchem-1346	230	48	,	,	PUNCT
eurjchem-1346	230	49	1521	1521	NUM
eurjchem-1346	230	50	,	,	PUNCT
eurjchem-1346	230	51	(	(	PUNCT
eurjchem-1346	230	52	c	c	NOUN
eurjchem-1346	230	53	=	=	SYM
eurjchem-1346	230	54	n	n	X
eurjchem-1346	230	55	,	,	PUNCT
eurjchem-1346	230	56	nh	nh	PROPN
eurjchem-1346	230	57	,	,	PUNCT
eurjchem-1346	230	58	c	c	X
eurjchem-1346	230	59	=	=	SYM
eurjchem-1346	230	60	c	c	NOUN
eurjchem-1346	230	61	)	)	PUNCT
eurjchem-1346	230	62	.	.	PUNCT
eurjchem-1346	231	1	1h	1h	NUM
eurjchem-1346	231	2	nmr	nmr	NOUN
eurjchem-1346	231	3	(	(	PUNCT
eurjchem-1346	231	4	400	400	NUM
eurjchem-1346	231	5	mhz	mhz	NOUN
eurjchem-1346	231	6	,	,	PUNCT
eurjchem-1346	231	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	231	8	,	,	PUNCT
eurjchem-1346	231	9	δ	δ	PROPN
eurjchem-1346	231	10	,	,	PUNCT
eurjchem-1346	231	11	ppm	ppm	NOUN
eurjchem-1346	231	12	):	):	PUNCT
eurjchem-1346	231	13	1.42	1.42	NUM
eurjchem-1346	231	14	(	(	PUNCT
eurjchem-1346	231	15	s	s	PROPN
eurjchem-1346	231	16	,	,	PUNCT
eurjchem-1346	231	17	3h	3h	NUM
eurjchem-1346	231	18	,	,	PUNCT
eurjchem-1346	231	19	ch3	ch3	PROPN
eurjchem-1346	231	20	)	)	PUNCT
eurjchem-1346	231	21	,	,	PUNCT
eurjchem-1346	231	22	2.50	2.50	NUM
eurjchem-1346	231	23	(	(	PUNCT
eurjchem-1346	231	24	s	s	PROPN
eurjchem-1346	231	25	,	,	PUNCT
eurjchem-1346	231	26	2h	2h	NUM
eurjchem-1346	231	27	,	,	PUNCT
eurjchem-1346	231	28	ch2	ch2	PROPN
eurjchem-1346	231	29	)	)	PUNCT
eurjchem-1346	231	30	,	,	PUNCT
eurjchem-1346	231	31	7.22	7.22	NUM
eurjchem-1346	231	32	(	(	PUNCT
eurjchem-1346	231	33	d	d	PROPN
eurjchem-1346	231	34	,	,	PUNCT
eurjchem-1346	231	35	j	j	PROPN
eurjchem-1346	231	36	=	=	SYM
eurjchem-1346	231	37	6.2	6.2	NUM
eurjchem-1346	231	38	hz	hz	NOUN
eurjchem-1346	231	39	,	,	PUNCT
eurjchem-1346	231	40	1h	1h	NUM
eurjchem-1346	231	41	,	,	PUNCT
eurjchem-1346	231	42	h‐8ar	h‐8ar	NOUN
eurjchem-1346	231	43	)	)	PUNCT
eurjchem-1346	231	44	,	,	PUNCT
eurjchem-1346	231	45	7.30‐7.43	7.30‐7.43	NUM
eurjchem-1346	231	46	(	(	PUNCT
eurjchem-1346	231	47	m	m	PROPN
eurjchem-1346	231	48	,	,	PUNCT
eurjchem-1346	231	49	3h	3h	NUM
eurjchem-1346	231	50	,	,	PUNCT
eurjchem-1346	231	51	h‐	h‐	PROPN
eurjchem-1346	231	52	3’,4’,5	3’,4’,5	NUM
eurjchem-1346	231	53	’	'	PUNCT
eurjchem-1346	231	54	ar	ar	NOUN
eurjchem-1346	231	55	)	)	PUNCT
eurjchem-1346	231	56	,	,	PUNCT
eurjchem-1346	231	57	7.49	7.49	NUM
eurjchem-1346	231	58	(	(	PUNCT
eurjchem-1346	231	59	t	t	PROPN
eurjchem-1346	231	60	,	,	PUNCT
eurjchem-1346	231	61	1h	1h	NUM
eurjchem-1346	231	62	,	,	PUNCT
eurjchem-1346	231	63	h‐7ar	h‐7ar	NOUN
eurjchem-1346	231	64	)	)	PUNCT
eurjchem-1346	231	65	,	,	PUNCT
eurjchem-1346	231	66	7.63	7.63	NUM
eurjchem-1346	231	67	(	(	PUNCT
eurjchem-1346	231	68	d	d	PROPN
eurjchem-1346	231	69	,	,	PUNCT
eurjchem-1346	231	70	j	j	PROPN
eurjchem-1346	231	71	=	=	SYM
eurjchem-1346	231	72	8.1	8.1	NUM
eurjchem-1346	231	73	hz	hz	VERB
eurjchem-1346	231	74	,	,	PUNCT
eurjchem-1346	231	75	2h	2h	NUM
eurjchem-1346	231	76	,	,	PUNCT
eurjchem-1346	231	77	h‐2’,6	h‐2’,6	NUM
eurjchem-1346	231	78	’	'	PUNCT
eurjchem-1346	231	79	ar	ar	NOUN
eurjchem-1346	231	80	)	)	PUNCT
eurjchem-1346	231	81	,	,	PUNCT
eurjchem-1346	231	82	8.22	8.22	NUM
eurjchem-1346	231	83	(	(	PUNCT
eurjchem-1346	231	84	d	d	PROPN
eurjchem-1346	231	85	,	,	PUNCT
eurjchem-1346	231	86	j	j	PROPN
eurjchem-1346	231	87	=	=	SYM
eurjchem-1346	231	88	7.2	7.2	NUM
eurjchem-1346	231	89	hz	hz	NOUN
eurjchem-1346	231	90	,	,	PUNCT
eurjchem-1346	231	91	1h	1h	NUM
eurjchem-1346	231	92	,	,	PUNCT
eurjchem-1346	231	93	h‐6ar	h‐6ar	NOUN
eurjchem-1346	231	94	)	)	PUNCT
eurjchem-1346	231	95	,	,	PUNCT
eurjchem-1346	231	96	11.31	11.31	NUM
eurjchem-1346	231	97	(	(	PUNCT
eurjchem-1346	231	98	s	s	PROPN
eurjchem-1346	231	99	,	,	PUNCT
eurjchem-1346	231	100	1h	1h	NUM
eurjchem-1346	231	101	,	,	PUNCT
eurjchem-1346	231	102	nh	nh	PROPN
eurjchem-1346	231	103	,	,	PUNCT
eurjchem-1346	231	104	exchanged	exchange	VERB
eurjchem-1346	231	105	with	with	ADP
eurjchem-1346	231	106	d2o	d2o	NOUN
eurjchem-1346	231	107	)	)	PUNCT
eurjchem-1346	231	108	,	,	PUNCT
eurjchem-1346	231	109	11.53	11.53	NUM
eurjchem-1346	231	110	(	(	PUNCT
eurjchem-1346	231	111	s	s	PROPN
eurjchem-1346	231	112	,	,	PUNCT
eurjchem-1346	231	113	1h	1h	NUM
eurjchem-1346	231	114	,	,	PUNCT
eurjchem-1346	231	115	nh	nh	PROPN
eurjchem-1346	231	116	,	,	PUNCT
eurjchem-1346	231	117	exchanged	exchange	VERB
eurjchem-1346	231	118	with	with	ADP
eurjchem-1346	231	119	d2o	d2o	NOUN
eurjchem-1346	231	120	)	)	PUNCT
eurjchem-1346	231	121	.	.	PUNCT
eurjchem-1346	232	1	anal	anal	PROPN
eurjchem-1346	232	2	.	.	PUNCT
eurjchem-1346	232	3	calcd	calcd	NOUN
eurjchem-1346	232	4	.	.	PUNCT
eurjchem-1346	233	1	for	for	ADP
eurjchem-1346	233	2	c16h15n5o	c16h15n5o	NOUN
eurjchem-1346	233	3	:	:	PUNCT
eurjchem-1346	233	4	c	c	X
eurjchem-1346	233	5	,	,	PUNCT
eurjchem-1346	233	6	65.52	65.52	NUM
eurjchem-1346	233	7	;	;	PUNCT
eurjchem-1346	233	8	h	h	NOUN
eurjchem-1346	233	9	,	,	PUNCT
eurjchem-1346	233	10	5.15	5.15	NUM
eurjchem-1346	233	11	;	;	PUNCT
eurjchem-1346	233	12	n	n	CCONJ
eurjchem-1346	233	13	,	,	PUNCT
eurjchem-1346	233	14	23.88	23.88	NUM
eurjchem-1346	233	15	.	.	PUNCT
eurjchem-1346	233	16	found	find	VERB
eurjchem-1346	233	17	:	:	PUNCT
eurjchem-1346	234	1	c	c	X
eurjchem-1346	234	2	,	,	PUNCT
eurjchem-1346	234	3	65.59	65.59	NUM
eurjchem-1346	234	4	;	;	PUNCT
eurjchem-1346	234	5	h	h	NOUN
eurjchem-1346	234	6	,	,	PUNCT
eurjchem-1346	234	7	5.12	5.12	NUM
eurjchem-1346	234	8	;	;	PUNCT
eurjchem-1346	234	9	n	n	CCONJ
eurjchem-1346	234	10	,	,	PUNCT
eurjchem-1346	234	11	23.98	23.98	NUM
eurjchem-1346	234	12	%	%	NOUN
eurjchem-1346	234	13	.	.	PUNCT
eurjchem-1346	235	1	2.1.6	2.1.6	X
eurjchem-1346	235	2	.	.	PROPN
eurjchem-1346	235	3	general	general	ADJ
eurjchem-1346	235	4	procedure	procedure	NOUN
eurjchem-1346	235	5	for	for	ADP
eurjchem-1346	235	6	synthesis	synthesis	NOUN
eurjchem-1346	235	7	of	of	ADP
eurjchem-1346	235	8	4‐(un)substituted	4‐(un)substituted	NUM
eurjchem-1346	235	9	phenyl‐2,5,10,11‐tetrahydropyrido[2,3‐g]pyrazino[4,3‐e	phenyl‐2,5,10,11‐tetrahydropyrido[2,3‐g]pyrazino[4,3‐e	PROPN
eurjchem-1346	235	10	]	]	X
eurjchem-1346	235	11	1,2,4‐triazin‐11‐ones	1,2,4‐triazin‐11‐ones	PROPN
eurjchem-1346	235	12	(	(	PUNCT
eurjchem-1346	235	13	6a‐d	6a‐d	NOUN
eurjchem-1346	235	14	)	)	PUNCT
eurjchem-1346	235	15	bromine	bromine	NOUN
eurjchem-1346	235	16	(	(	PUNCT
eurjchem-1346	235	17	1.60	1.60	NUM
eurjchem-1346	235	18	g	g	NOUN
eurjchem-1346	235	19	,	,	PUNCT
eurjchem-1346	235	20	0.53	0.53	NUM
eurjchem-1346	235	21	ml	ml	NOUN
eurjchem-1346	235	22	,	,	PUNCT
eurjchem-1346	235	23	0.01	0.01	NUM
eurjchem-1346	235	24	mol	mol	NOUN
eurjchem-1346	235	25	)	)	PUNCT
eurjchem-1346	235	26	in	in	ADP
eurjchem-1346	235	27	glacial	glacial	ADJ
eurjchem-1346	235	28	acetic	acetic	ADJ
eurjchem-1346	235	29	acid	acid	NOUN
eurjchem-1346	235	30	(	(	PUNCT
eurjchem-1346	235	31	0.6	0.6	NUM
eurjchem-1346	235	32	ml	ml	NOUN
eurjchem-1346	235	33	)	)	PUNCT
eurjchem-1346	235	34	was	be	AUX
eurjchem-1346	235	35	added	add	VERB
eurjchem-1346	235	36	dropwise	dropwise	NOUN
eurjchem-1346	235	37	to	to	ADP
eurjchem-1346	235	38	solution	solution	NOUN
eurjchem-1346	235	39	of	of	ADP
eurjchem-1346	235	40	compound	compound	NOUN
eurjchem-1346	235	41	5a‐d	5a‐d	NOUN
eurjchem-1346	235	42	(	(	PUNCT
eurjchem-1346	235	43	0.01	0.01	NUM
eurjchem-1346	235	44	mol	mol	NOUN
eurjchem-1346	235	45	)	)	PUNCT
eurjchem-1346	235	46	in	in	ADP
eurjchem-1346	235	47	glacial	glacial	ADJ
eurjchem-1346	235	48	acetic	acetic	ADJ
eurjchem-1346	235	49	acid	acid	NOUN
eurjchem-1346	235	50	(	(	PUNCT
eurjchem-1346	235	51	9	9	NUM
eurjchem-1346	235	52	ml	ml	NOUN
eurjchem-1346	235	53	)	)	PUNCT
eurjchem-1346	235	54	containing	contain	VERB
eurjchem-1346	235	55	sodium	sodium	NOUN
eurjchem-1346	235	56	acetate	acetate	NOUN
eurjchem-1346	235	57	(	(	PUNCT
eurjchem-1346	235	58	2.46	2.46	NUM
eurjchem-1346	235	59	g	g	NOUN
eurjchem-1346	235	60	,	,	PUNCT
eurjchem-1346	235	61	0.03	0.03	NUM
eurjchem-1346	235	62	mol	mol	NOUN
eurjchem-1346	235	63	)	)	PUNCT
eurjchem-1346	235	64	at	at	ADP
eurjchem-1346	235	65	room	room	NOUN
eurjchem-1346	235	66	temperature	temperature	NOUN
eurjchem-1346	235	67	.	.	PUNCT
eurjchem-1346	236	1	the	the	DET
eurjchem-1346	236	2	mixture	mixture	NOUN
eurjchem-1346	236	3	was	be	AUX
eurjchem-1346	236	4	stirred	stir	VERB
eurjchem-1346	236	5	for	for	ADP
eurjchem-1346	236	6	3	3	NUM
eurjchem-1346	236	7	h	h	NOUN
eurjchem-1346	236	8	at	at	ADP
eurjchem-1346	236	9	room	room	NOUN
eurjchem-1346	236	10	temperature	temperature	NOUN
eurjchem-1346	236	11	then	then	ADV
eurjchem-1346	236	12	poured	pour	VERB
eurjchem-1346	236	13	onto	onto	ADP
eurjchem-1346	236	14	cold	cold	ADJ
eurjchem-1346	236	15	water	water	NOUN
eurjchem-1346	236	16	(	(	PUNCT
eurjchem-1346	236	17	50	50	NUM
eurjchem-1346	236	18	ml	ml	NOUN
eurjchem-1346	236	19	)	)	PUNCT
eurjchem-1346	236	20	.	.	PUNCT
eurjchem-1346	237	1	the	the	DET
eurjchem-1346	237	2	formed	form	VERB
eurjchem-1346	237	3	precipitate	precipitate	NOUN
eurjchem-1346	237	4	was	be	AUX
eurjchem-1346	237	5	filtered	filter	VERB
eurjchem-1346	237	6	,	,	PUNCT
eurjchem-1346	237	7	washed	wash	VERB
eurjchem-1346	237	8	with	with	ADP
eurjchem-1346	237	9	water	water	NOUN
eurjchem-1346	237	10	(	(	PUNCT
eurjchem-1346	237	11	10	10	NUM
eurjchem-1346	237	12	ml	ml	NOUN
eurjchem-1346	237	13	)	)	PUNCT
eurjchem-1346	237	14	and	and	CCONJ
eurjchem-1346	237	15	dried	dry	VERB
eurjchem-1346	237	16	.	.	PUNCT
eurjchem-1346	238	1	the	the	DET
eurjchem-1346	238	2	crude	crude	ADJ
eurjchem-1346	238	3	product	product	NOUN
eurjchem-1346	238	4	was	be	AUX
eurjchem-1346	238	5	crystallized	crystallize	VERB
eurjchem-1346	238	6	from	from	ADP
eurjchem-1346	238	7	acetic	acetic	ADJ
eurjchem-1346	238	8	acid	acid	NOUN
eurjchem-1346	238	9	(	(	PUNCT
eurjchem-1346	238	10	scheme	scheme	NOUN
eurjchem-1346	238	11	1	1	NUM
eurjchem-1346	238	12	)	)	PUNCT
eurjchem-1346	238	13	.	.	PUNCT
eurjchem-1346	239	1	amin	amin	PROPN
eurjchem-1346	239	2	et	et	PROPN
eurjchem-1346	239	3	al	al	PROPN
eurjchem-1346	239	4	.	.	PUNCT
eurjchem-1346	239	5	/	/	SYM
eurjchem-1346	239	6	european	european	PROPN
eurjchem-1346	239	7	journal	journal	PROPN
eurjchem-1346	239	8	of	of	ADP
eurjchem-1346	239	9	chemistry	chemistry	NOUN
eurjchem-1346	239	10	7	7	NUM
eurjchem-1346	239	11	(	(	PUNCT
eurjchem-1346	239	12	1	1	NUM
eurjchem-1346	239	13	)	)	PUNCT
eurjchem-1346	239	14	(	(	PUNCT
eurjchem-1346	239	15	2016	2016	NUM
eurjchem-1346	239	16	)	)	PUNCT
eurjchem-1346	239	17	19‐29	19‐29	PROPN
eurjchem-1346	239	18	23	23	NUM
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eurjchem-1346	240	2	,	,	PUNCT
eurjchem-1346	240	3	3‐g]pyrazino[4	3‐g]pyrazino[4	NUM
eurjchem-1346	240	4	,	,	PUNCT
eurjchem-1346	240	5	3‐e	3‐e	NUM
eurjchem-1346	240	6	]	]	PUNCT
eurjchem-1346	240	7	1,2,4‐triazin‐11‐one	1,2,4‐triazin‐11‐one	NUM
eurjchem-1346	240	8	(	(	PUNCT
eurjchem-1346	240	9	6a	6a	NOUN
eurjchem-1346	240	10	):	):	PUNCT
eurjchem-1346	240	11	yield	yield	NOUN
eurjchem-1346	240	12	:	:	PUNCT
eurjchem-1346	240	13	80	80	NUM
eurjchem-1346	240	14	%	%	NOUN
eurjchem-1346	240	15	.	.	PUNCT
eurjchem-1346	241	1	m.p	m.p	PROPN
eurjchem-1346	241	2	.	.	PROPN
eurjchem-1346	241	3	:	:	PUNCT
eurjchem-1346	242	1	219‐221	219‐221	NUM
eurjchem-1346	242	2	°	°	ADP
eurjchem-1346	242	3	c	c	NOUN
eurjchem-1346	242	4	.	.	PUNCT
eurjchem-1346	243	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	243	2	(	(	PUNCT
eurjchem-1346	243	3	kbr	kbr	PROPN
eurjchem-1346	243	4	,	,	PUNCT
eurjchem-1346	243	5			PROPN
eurjchem-1346	243	6	,	,	PUNCT
eurjchem-1346	243	7	cm‐1	cm‐1	PROPN
eurjchem-1346	243	8	):	):	PUNCT
eurjchem-1346	243	9	3365	3365	NUM
eurjchem-1346	243	10	,	,	PUNCT
eurjchem-1346	243	11	3355	3355	NUM
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eurjchem-1346	243	13	2nh	2nh	NOUN
eurjchem-1346	243	14	)	)	PUNCT
eurjchem-1346	243	15	,	,	PUNCT
eurjchem-1346	243	16	3035	3035	NUM
eurjchem-1346	243	17	(	(	PUNCT
eurjchem-1346	243	18	ch	ch	PROPN
eurjchem-1346	243	19	ar	ar	PROPN
eurjchem-1346	243	20	)	)	PUNCT
eurjchem-1346	243	21	,	,	PUNCT
eurjchem-1346	243	22	1760	1760	NUM
eurjchem-1346	243	23	(	(	PUNCT
eurjchem-1346	243	24	c	c	NOUN
eurjchem-1346	243	25	=	=	NOUN
eurjchem-1346	243	26	o	o	NOUN
eurjchem-1346	243	27	)	)	PUNCT
eurjchem-1346	243	28	,	,	PUNCT
eurjchem-1346	243	29	1608	1608	NUM
eurjchem-1346	243	30	,	,	PUNCT
eurjchem-1346	243	31	1558	1558	NUM
eurjchem-1346	243	32	,	,	PUNCT
eurjchem-1346	243	33	1541	1541	NUM
eurjchem-1346	243	34	,	,	PUNCT
eurjchem-1346	243	35	1521	1521	NUM
eurjchem-1346	243	36	,	,	PUNCT
eurjchem-1346	243	37	1508	1508	NUM
eurjchem-1346	243	38	(	(	PUNCT
eurjchem-1346	243	39	c	c	NOUN
eurjchem-1346	243	40	=	=	SYM
eurjchem-1346	243	41	n	n	X
eurjchem-1346	243	42	,	,	PUNCT
eurjchem-1346	243	43	nh	nh	PROPN
eurjchem-1346	243	44	,	,	PUNCT
eurjchem-1346	243	45	c	c	X
eurjchem-1346	243	46	=	=	SYM
eurjchem-1346	243	47	c	c	NOUN
eurjchem-1346	243	48	)	)	PUNCT
eurjchem-1346	243	49	.	.	PUNCT
eurjchem-1346	244	1	1h	1h	NUM
eurjchem-1346	244	2	nmr	nmr	NOUN
eurjchem-1346	244	3	(	(	PUNCT
eurjchem-1346	244	4	400	400	NUM
eurjchem-1346	244	5	mhz	mhz	NOUN
eurjchem-1346	244	6	,	,	PUNCT
eurjchem-1346	244	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	244	8	,	,	PUNCT
eurjchem-1346	244	9	δ	δ	PROPN
eurjchem-1346	244	10	,	,	PUNCT
eurjchem-1346	244	11	ppm	ppm	NUM
eurjchem-1346	244	12	):	):	PUNCT
eurjchem-1346	244	13	6.01	6.01	NUM
eurjchem-1346	244	14	(	(	PUNCT
eurjchem-1346	244	15	s	s	PROPN
eurjchem-1346	244	16	,	,	PUNCT
eurjchem-1346	244	17	1h	1h	NUM
eurjchem-1346	244	18	,	,	PUNCT
eurjchem-1346	244	19	h‐1	h‐1	PROPN
eurjchem-1346	244	20	ar	ar	PROPN
eurjchem-1346	244	21	)	)	PUNCT
eurjchem-1346	244	22	,	,	PUNCT
eurjchem-1346	244	23	6.99	6.99	NUM
eurjchem-1346	244	24	(	(	PUNCT
eurjchem-1346	244	25	t	t	PROPN
eurjchem-1346	244	26	,	,	PUNCT
eurjchem-1346	244	27	1h	1h	NUM
eurjchem-1346	244	28	,	,	PUNCT
eurjchem-1346	244	29	h‐8	h‐8	PROPN
eurjchem-1346	244	30	ar	ar	PROPN
eurjchem-1346	244	31	)	)	PUNCT
eurjchem-1346	244	32	,	,	PUNCT
eurjchem-1346	244	33	7.01	7.01	NUM
eurjchem-1346	244	34	(	(	PUNCT
eurjchem-1346	244	35	d	d	PROPN
eurjchem-1346	244	36	,	,	PUNCT
eurjchem-1346	244	37	j	j	PROPN
eurjchem-1346	244	38	=	=	SYM
eurjchem-1346	244	39	6.4	6.4	NUM
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eurjchem-1346	244	41	,	,	PUNCT
eurjchem-1346	244	42	1h	1h	NUM
eurjchem-1346	244	43	,	,	PUNCT
eurjchem-1346	244	44	h‐9	h‐9	X
eurjchem-1346	244	45	ar	ar	PROPN
eurjchem-1346	244	46	)	)	PUNCT
eurjchem-1346	244	47	,	,	PUNCT
eurjchem-1346	244	48	7.29‐7.41	7.29‐7.41	NUM
eurjchem-1346	244	49	(	(	PUNCT
eurjchem-1346	244	50	m	m	PROPN
eurjchem-1346	244	51	,	,	PUNCT
eurjchem-1346	244	52	3h	3h	NUM
eurjchem-1346	244	53	,	,	PUNCT
eurjchem-1346	244	54	h‐3’,4’,5	h‐3’,4’,5	PROPN
eurjchem-1346	244	55	’	'	PUNCT
eurjchem-1346	244	56	ar	ar	PROPN
eurjchem-1346	244	57	)	)	PUNCT
eurjchem-1346	244	58	,	,	PUNCT
eurjchem-1346	244	59	7.63	7.63	NUM
eurjchem-1346	244	60	(	(	PUNCT
eurjchem-1346	244	61	d	d	PROPN
eurjchem-1346	244	62	,	,	PUNCT
eurjchem-1346	244	63	j	j	PROPN
eurjchem-1346	245	1	=	=	SYM
eurjchem-1346	245	2	7.2	7.2	NUM
eurjchem-1346	245	3	hz	hz	NOUN
eurjchem-1346	245	4	,	,	PUNCT
eurjchem-1346	245	5	2h	2h	NUM
eurjchem-1346	245	6	,	,	PUNCT
eurjchem-1346	245	7	h‐2’,6	h‐2’,6	NUM
eurjchem-1346	245	8	’	'	PUNCT
eurjchem-1346	245	9	ar	ar	NOUN
eurjchem-1346	245	10	)	)	PUNCT
eurjchem-1346	245	11	,	,	PUNCT
eurjchem-1346	245	12	7.91	7.91	NUM
eurjchem-1346	245	13	(	(	PUNCT
eurjchem-1346	245	14	d	d	PROPN
eurjchem-1346	245	15	,	,	PUNCT
eurjchem-1346	245	16	j	j	PROPN
eurjchem-1346	245	17	=	=	SYM
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eurjchem-1346	245	19	hz	hz	NOUN
eurjchem-1346	245	20	,	,	PUNCT
eurjchem-1346	245	21	1h	1h	NUM
eurjchem-1346	245	22	,	,	PUNCT
eurjchem-1346	245	23	h‐	h‐	PROPN
eurjchem-1346	245	24	7	7	NUM
eurjchem-1346	245	25	ar),11.29	ar),11.29	NUM
eurjchem-1346	245	26	(	(	PUNCT
eurjchem-1346	245	27	s	s	PROPN
eurjchem-1346	245	28	,	,	PUNCT
eurjchem-1346	245	29	1h	1h	NUM
eurjchem-1346	245	30	,	,	PUNCT
eurjchem-1346	245	31	nh	nh	PROPN
eurjchem-1346	245	32	,	,	PUNCT
eurjchem-1346	245	33	,	,	PUNCT
eurjchem-1346	245	34	exchanged	exchange	VERB
eurjchem-1346	245	35	with	with	ADP
eurjchem-1346	245	36	d2o	d2o	NOUN
eurjchem-1346	245	37	)	)	PUNCT
eurjchem-1346	245	38	,	,	PUNCT
eurjchem-1346	245	39	11.52	11.52	NUM
eurjchem-1346	245	40	(	(	PUNCT
eurjchem-1346	245	41	s	s	PROPN
eurjchem-1346	245	42	,	,	PUNCT
eurjchem-1346	245	43	1h	1h	NUM
eurjchem-1346	245	44	,	,	PUNCT
eurjchem-1346	245	45	exchanged	exchange	VERB
eurjchem-1346	245	46	with	with	ADP
eurjchem-1346	245	47	d2o	d2o	NOUN
eurjchem-1346	245	48	)	)	PUNCT
eurjchem-1346	245	49	.	.	PUNCT
eurjchem-1346	246	1	anal	anal	PROPN
eurjchem-1346	246	2	.	.	PUNCT
eurjchem-1346	246	3	calcd	calcd	NOUN
eurjchem-1346	246	4	.	.	PUNCT
eurjchem-1346	247	1	for	for	SCONJ
eurjchem-1346	247	2	c15h11n5o	c15h11n5o	NOUN
eurjchem-1346	247	3	:	:	PUNCT
eurjchem-1346	247	4	c	c	X
eurjchem-1346	247	5	,	,	PUNCT
eurjchem-1346	247	6	64.97	64.97	NUM
eurjchem-1346	247	7	;	;	PUNCT
eurjchem-1346	247	8	h	h	NOUN
eurjchem-1346	247	9	,	,	PUNCT
eurjchem-1346	247	10	4.00	4.00	NUM
eurjchem-1346	247	11	;	;	PUNCT
eurjchem-1346	247	12	n	n	CCONJ
eurjchem-1346	247	13	,	,	PUNCT
eurjchem-1346	247	14	25.26	25.26	NUM
eurjchem-1346	247	15	.	.	PUNCT
eurjchem-1346	247	16	found	find	VERB
eurjchem-1346	247	17	:	:	PUNCT
eurjchem-1346	248	1	c	c	X
eurjchem-1346	248	2	,	,	PUNCT
eurjchem-1346	248	3	65.13	65.13	NUM
eurjchem-1346	248	4	;	;	PUNCT
eurjchem-1346	248	5	h	h	NOUN
eurjchem-1346	248	6	,	,	PUNCT
eurjchem-1346	248	7	4.06	4.06	NUM
eurjchem-1346	248	8	;	;	PUNCT
eurjchem-1346	248	9	n	n	CCONJ
eurjchem-1346	248	10	,	,	PUNCT
eurjchem-1346	248	11	25.49	25.49	NUM
eurjchem-1346	248	12	%	%	NOUN
eurjchem-1346	248	13	.	.	PUNCT
eurjchem-1346	249	1	4‐(4‐chlorophenyl)‐2	4‐(4‐chlorophenyl)‐2	NUM
eurjchem-1346	249	2	,	,	PUNCT
eurjchem-1346	249	3	5	5	NUM
eurjchem-1346	249	4	,	,	PUNCT
eurjchem-1346	249	5	10	10	NUM
eurjchem-1346	249	6	,	,	PUNCT
eurjchem-1346	249	7	11‐tetrahydropyrido[2	11‐tetrahydropyrido[2	NUM
eurjchem-1346	249	8	,	,	PUNCT
eurjchem-1346	249	9	3‐g	3‐g	NOUN
eurjchem-1346	249	10	]	]	PUNCT
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eurjchem-1346	249	12	(	(	PUNCT
eurjchem-1346	249	13	6b	6b	NOUN
eurjchem-1346	249	14	):	):	PUNCT
eurjchem-1346	249	15	yield	yield	NOUN
eurjchem-1346	249	16	:	:	PUNCT
eurjchem-1346	249	17	75	75	NUM
eurjchem-1346	249	18	%	%	NOUN
eurjchem-1346	249	19	.	.	PUNCT
eurjchem-1346	250	1	m.p	m.p	PROPN
eurjchem-1346	250	2	.	.	PROPN
eurjchem-1346	250	3	:	:	PUNCT
eurjchem-1346	251	1	222‐	222‐	NUM
eurjchem-1346	251	2	225	225	NUM
eurjchem-1346	251	3	°	°	NOUN
eurjchem-1346	251	4	c	c	X
eurjchem-1346	251	5	.	.	PUNCT
eurjchem-1346	252	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	252	2	(	(	PUNCT
eurjchem-1346	252	3	kbr	kbr	PROPN
eurjchem-1346	252	4	,	,	PUNCT
eurjchem-1346	252	5			PROPN
eurjchem-1346	252	6	,	,	PUNCT
eurjchem-1346	252	7	cm‐1	cm‐1	PROPN
eurjchem-1346	252	8	):	):	PUNCT
eurjchem-1346	252	9	3390	3390	NUM
eurjchem-1346	252	10	,	,	PUNCT
eurjchem-1346	252	11	3385	3385	NUM
eurjchem-1346	252	12	(	(	PUNCT
eurjchem-1346	252	13	2nh	2nh	PROPN
eurjchem-1346	252	14	)	)	PUNCT
eurjchem-1346	252	15	,	,	PUNCT
eurjchem-1346	252	16	3032	3032	NUM
eurjchem-1346	252	17	(	(	PUNCT
eurjchem-1346	252	18	ch	ch	PROPN
eurjchem-1346	252	19	ar	ar	PROPN
eurjchem-1346	252	20	)	)	PUNCT
eurjchem-1346	252	21	,	,	PUNCT
eurjchem-1346	252	22	1680	1680	NUM
eurjchem-1346	252	23	(	(	PUNCT
eurjchem-1346	252	24	c	c	NOUN
eurjchem-1346	252	25	=	=	NOUN
eurjchem-1346	252	26	o	o	NOUN
eurjchem-1346	252	27	)	)	PUNCT
eurjchem-1346	252	28	,	,	PUNCT
eurjchem-1346	252	29	1635	1635	NUM
eurjchem-1346	252	30	,	,	PUNCT
eurjchem-1346	252	31	1608	1608	NUM
eurjchem-1346	252	32	,	,	PUNCT
eurjchem-1346	252	33	1593	1593	NUM
eurjchem-1346	252	34	,	,	PUNCT
eurjchem-1346	252	35	1570	1570	NUM
eurjchem-1346	252	36	,	,	PUNCT
eurjchem-1346	252	37	1558	1558	NUM
eurjchem-1346	252	38	(	(	PUNCT
eurjchem-1346	252	39	c	c	NOUN
eurjchem-1346	252	40	=	=	SYM
eurjchem-1346	252	41	n	n	X
eurjchem-1346	252	42	,	,	PUNCT
eurjchem-1346	252	43	nh	nh	PROPN
eurjchem-1346	252	44	,	,	PUNCT
eurjchem-1346	252	45	c	c	X
eurjchem-1346	252	46	=	=	SYM
eurjchem-1346	252	47	c	c	NOUN
eurjchem-1346	252	48	)	)	PUNCT
eurjchem-1346	252	49	.	.	PUNCT
eurjchem-1346	253	1	1h	1h	NUM
eurjchem-1346	253	2	nmr	nmr	NOUN
eurjchem-1346	253	3	(	(	PUNCT
eurjchem-1346	253	4	400	400	NUM
eurjchem-1346	253	5	mhz	mhz	NOUN
eurjchem-1346	253	6	,	,	PUNCT
eurjchem-1346	253	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	253	8	,	,	PUNCT
eurjchem-1346	253	9	δ	δ	PROPN
eurjchem-1346	253	10	,	,	PUNCT
eurjchem-1346	253	11	ppm	ppm	NUM
eurjchem-1346	253	12	):	):	PUNCT
eurjchem-1346	253	13	5.99	5.99	NUM
eurjchem-1346	253	14	(	(	PUNCT
eurjchem-1346	253	15	s	s	PROPN
eurjchem-1346	253	16	,	,	PUNCT
eurjchem-1346	253	17	1h	1h	NUM
eurjchem-1346	253	18	,	,	PUNCT
eurjchem-1346	253	19	h‐1	h‐1	PROPN
eurjchem-1346	253	20	ar	ar	PROPN
eurjchem-1346	253	21	)	)	PUNCT
eurjchem-1346	253	22	,	,	PUNCT
eurjchem-1346	253	23	6.86	6.86	NUM
eurjchem-1346	253	24	(	(	PUNCT
eurjchem-1346	253	25	t	t	PROPN
eurjchem-1346	253	26	,	,	PUNCT
eurjchem-1346	253	27	1h	1h	NUM
eurjchem-1346	253	28	,	,	PUNCT
eurjchem-1346	253	29	h‐8	h‐8	PROPN
eurjchem-1346	253	30	ar	ar	PROPN
eurjchem-1346	253	31	)	)	PUNCT
eurjchem-1346	253	32	,	,	PUNCT
eurjchem-1346	253	33	7.02	7.02	NUM
eurjchem-1346	253	34	(	(	PUNCT
eurjchem-1346	253	35	d	d	PROPN
eurjchem-1346	253	36	,	,	PUNCT
eurjchem-1346	253	37	j	j	PROPN
eurjchem-1346	253	38	=	=	SYM
eurjchem-1346	253	39	8.1	8.1	NUM
eurjchem-1346	253	40	hz	hz	NOUN
eurjchem-1346	253	41	,	,	PUNCT
eurjchem-1346	253	42	1h	1h	NUM
eurjchem-1346	253	43	,	,	PUNCT
eurjchem-1346	253	44	h‐9	h‐9	ADP
eurjchem-1346	253	45	ar	ar	PROPN
eurjchem-1346	253	46	)	)	PUNCT
eurjchem-1346	253	47	,	,	PUNCT
eurjchem-1346	253	48	7.33	7.33	NUM
eurjchem-1346	253	49	(	(	PUNCT
eurjchem-1346	253	50	d	d	PROPN
eurjchem-1346	253	51	,	,	PUNCT
eurjchem-1346	253	52	j	j	PROPN
eurjchem-1346	254	1	=	=	SYM
eurjchem-1346	254	2	7.0	7.0	NUM
eurjchem-1346	254	3	hz	hz	NOUN
eurjchem-1346	254	4	,	,	PUNCT
eurjchem-1346	254	5	2h	2h	NUM
eurjchem-1346	254	6	,	,	PUNCT
eurjchem-1346	254	7	h‐3’,5	h‐3’,5	NOUN
eurjchem-1346	254	8	’	'	PUNCT
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eurjchem-1346	254	10	)	)	PUNCT
eurjchem-1346	254	11	,	,	PUNCT
eurjchem-1346	254	12	7.62	7.62	NUM
eurjchem-1346	254	13	(	(	PUNCT
eurjchem-1346	254	14	d	d	PROPN
eurjchem-1346	254	15	,	,	PUNCT
eurjchem-1346	254	16	j	j	PROPN
eurjchem-1346	254	17	=	=	SYM
eurjchem-1346	254	18	6.5	6.5	NUM
eurjchem-1346	254	19	hz	hz	NOUN
eurjchem-1346	254	20	,	,	PUNCT
eurjchem-1346	254	21	2h	2h	NUM
eurjchem-1346	254	22	,	,	PUNCT
eurjchem-1346	254	23	h‐2’,6	h‐2’,6	NUM
eurjchem-1346	254	24	’	'	PUNCT
eurjchem-1346	254	25	ar	ar	NOUN
eurjchem-1346	254	26	)	)	PUNCT
eurjchem-1346	254	27	,	,	PUNCT
eurjchem-1346	254	28	8.22	8.22	NUM
eurjchem-1346	254	29	(	(	PUNCT
eurjchem-1346	254	30	d	d	PROPN
eurjchem-1346	254	31	,	,	PUNCT
eurjchem-1346	254	32	j	j	PROPN
eurjchem-1346	254	33	=	=	SYM
eurjchem-1346	254	34	6.3	6.3	NUM
eurjchem-1346	254	35	hz	hz	NOUN
eurjchem-1346	254	36	,	,	PUNCT
eurjchem-1346	254	37	1h	1h	NUM
eurjchem-1346	254	38	,	,	PUNCT
eurjchem-1346	254	39	h‐7	h‐7	PROPN
eurjchem-1346	254	40	ar	ar	PROPN
eurjchem-1346	254	41	)	)	PUNCT
eurjchem-1346	254	42	,	,	PUNCT
eurjchem-1346	254	43	11.31	11.31	NUM
eurjchem-1346	254	44	(	(	PUNCT
eurjchem-1346	254	45	s	s	PROPN
eurjchem-1346	254	46	,	,	PUNCT
eurjchem-1346	254	47	1h	1h	NUM
eurjchem-1346	254	48	,	,	PUNCT
eurjchem-1346	254	49	nh	nh	PROPN
eurjchem-1346	254	50	,	,	PUNCT
eurjchem-1346	254	51	exchanged	exchange	VERB
eurjchem-1346	254	52	with	with	ADP
eurjchem-1346	254	53	d2o	d2o	NOUN
eurjchem-1346	254	54	)	)	PUNCT
eurjchem-1346	254	55	,	,	PUNCT
eurjchem-1346	254	56	11.53	11.53	NUM
eurjchem-1346	254	57	(	(	PUNCT
eurjchem-1346	254	58	s	s	PROPN
eurjchem-1346	254	59	,	,	PUNCT
eurjchem-1346	254	60	1h	1h	NUM
eurjchem-1346	254	61	,	,	PUNCT
eurjchem-1346	254	62	nh	nh	PROPN
eurjchem-1346	254	63	,	,	PUNCT
eurjchem-1346	254	64	exchanged	exchange	VERB
eurjchem-1346	254	65	with	with	ADP
eurjchem-1346	254	66	d2o	d2o	NOUN
eurjchem-1346	254	67	)	)	PUNCT
eurjchem-1346	254	68	.	.	PUNCT
eurjchem-1346	255	1	anal	anal	PROPN
eurjchem-1346	255	2	.	.	PUNCT
eurjchem-1346	255	3	calcd	calcd	NOUN
eurjchem-1346	255	4	.	.	PUNCT
eurjchem-1346	256	1	for	for	ADP
eurjchem-1346	256	2	c15h10cln5o	c15h10cln5o	NOUN
eurjchem-1346	256	3	:	:	PUNCT
eurjchem-1346	256	4	c	c	X
eurjchem-1346	256	5	,	,	PUNCT
eurjchem-1346	256	6	57.79	57.79	NUM
eurjchem-1346	256	7	;	;	PUNCT
eurjchem-1346	256	8	h	h	NOUN
eurjchem-1346	256	9	,	,	PUNCT
eurjchem-1346	256	10	3.23	3.23	NUM
eurjchem-1346	256	11	;	;	PUNCT
eurjchem-1346	256	12	n	n	CCONJ
eurjchem-1346	256	13	,	,	PUNCT
eurjchem-1346	256	14	22.47	22.47	NUM
eurjchem-1346	256	15	.	.	PUNCT
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eurjchem-1346	256	17	:	:	PUNCT
eurjchem-1346	257	1	c	c	X
eurjchem-1346	257	2	,	,	PUNCT
eurjchem-1346	257	3	57.96	57.96	NUM
eurjchem-1346	257	4	;	;	PUNCT
eurjchem-1346	257	5	h	h	NOUN
eurjchem-1346	257	6	,	,	PUNCT
eurjchem-1346	257	7	3.19	3.19	NUM
eurjchem-1346	257	8	;	;	PUNCT
eurjchem-1346	257	9	n	n	CCONJ
eurjchem-1346	257	10	,	,	PUNCT
eurjchem-1346	257	11	22.63	22.63	NUM
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eurjchem-1346	257	13	.	.	PUNCT
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eurjchem-1346	258	2	,	,	PUNCT
eurjchem-1346	258	3	5	5	NUM
eurjchem-1346	258	4	,	,	PUNCT
eurjchem-1346	258	5	10	10	NUM
eurjchem-1346	258	6	,	,	PUNCT
eurjchem-1346	258	7	11‐tetrahydropyrido[2	11‐tetrahydropyrido[2	NUM
eurjchem-1346	258	8	,	,	PUNCT
eurjchem-1346	258	9	3‐g	3‐g	NOUN
eurjchem-1346	258	10	]	]	PUNCT
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eurjchem-1346	258	12	(	(	PUNCT
eurjchem-1346	258	13	6c	6c	NOUN
eurjchem-1346	258	14	):	):	PUNCT
eurjchem-1346	258	15	yield	yield	NOUN
eurjchem-1346	258	16	:	:	PUNCT
eurjchem-1346	258	17	86	86	NUM
eurjchem-1346	258	18	%	%	NOUN
eurjchem-1346	258	19	.	.	PUNCT
eurjchem-1346	259	1	m.p	m.p	PROPN
eurjchem-1346	259	2	.	.	PROPN
eurjchem-1346	259	3	:	:	PUNCT
eurjchem-1346	260	1	222‐	222‐	NUM
eurjchem-1346	261	1	224	224	NUM
eurjchem-1346	261	2	°	°	SYM
eurjchem-1346	261	3	c	c	X
eurjchem-1346	261	4	.	.	PUNCT
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eurjchem-1346	262	2	(	(	PUNCT
eurjchem-1346	262	3	kbr	kbr	PROPN
eurjchem-1346	262	4	,	,	PUNCT
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eurjchem-1346	262	8	):	):	PUNCT
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eurjchem-1346	262	10	,	,	PUNCT
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eurjchem-1346	262	12	(	(	PUNCT
eurjchem-1346	262	13	2nh	2nh	NOUN
eurjchem-1346	262	14	)	)	PUNCT
eurjchem-1346	262	15	,	,	PUNCT
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eurjchem-1346	262	17	(	(	PUNCT
eurjchem-1346	262	18	ch	ch	PROPN
eurjchem-1346	262	19	ar	ar	PROPN
eurjchem-1346	262	20	)	)	PUNCT
eurjchem-1346	262	21	,	,	PUNCT
eurjchem-1346	262	22	1674	1674	NUM
eurjchem-1346	262	23	(	(	PUNCT
eurjchem-1346	262	24	c	c	NOUN
eurjchem-1346	262	25	=	=	NOUN
eurjchem-1346	262	26	o	o	NOUN
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eurjchem-1346	262	28	,	,	PUNCT
eurjchem-1346	262	29	1654	1654	NUM
eurjchem-1346	262	30	,	,	PUNCT
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eurjchem-1346	262	32	,	,	PUNCT
eurjchem-1346	262	33	1600	1600	NUM
eurjchem-1346	262	34	,	,	PUNCT
eurjchem-1346	262	35	1568	1568	NUM
eurjchem-1346	262	36	,	,	PUNCT
eurjchem-1346	262	37	1558	1558	NUM
eurjchem-1346	262	38	(	(	PUNCT
eurjchem-1346	262	39	c	c	NOUN
eurjchem-1346	262	40	=	=	SYM
eurjchem-1346	262	41	n	n	X
eurjchem-1346	262	42	,	,	PUNCT
eurjchem-1346	262	43	nh	nh	PROPN
eurjchem-1346	262	44	,	,	PUNCT
eurjchem-1346	262	45	c	c	X
eurjchem-1346	262	46	=	=	SYM
eurjchem-1346	262	47	c	c	NOUN
eurjchem-1346	262	48	)	)	PUNCT
eurjchem-1346	262	49	,	,	PUNCT
eurjchem-1346	262	50	1521	1521	NUM
eurjchem-1346	262	51	,	,	PUNCT
eurjchem-1346	262	52	1346	1346	NUM
eurjchem-1346	262	53	(	(	PUNCT
eurjchem-1346	262	54	no2	no2	NOUN
eurjchem-1346	262	55	)	)	PUNCT
eurjchem-1346	262	56	.	.	PUNCT
eurjchem-1346	263	1	1h	1h	NUM
eurjchem-1346	263	2	nmr	nmr	NOUN
eurjchem-1346	263	3	(	(	PUNCT
eurjchem-1346	263	4	400	400	NUM
eurjchem-1346	263	5	mhz	mhz	NOUN
eurjchem-1346	263	6	,	,	PUNCT
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eurjchem-1346	263	8	,	,	PUNCT
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eurjchem-1346	263	10	,	,	PUNCT
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eurjchem-1346	263	14	(	(	PUNCT
eurjchem-1346	263	15	s	s	PROPN
eurjchem-1346	263	16	,	,	PUNCT
eurjchem-1346	263	17	1h	1h	NUM
eurjchem-1346	263	18	,	,	PUNCT
eurjchem-1346	263	19	h‐1	h‐1	PROPN
eurjchem-1346	263	20	ar	ar	PROPN
eurjchem-1346	263	21	)	)	PUNCT
eurjchem-1346	263	22	,	,	PUNCT
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eurjchem-1346	263	24	(	(	PUNCT
eurjchem-1346	263	25	t	t	PROPN
eurjchem-1346	263	26	,	,	PUNCT
eurjchem-1346	263	27	1h	1h	NUM
eurjchem-1346	263	28	,	,	PUNCT
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eurjchem-1346	263	30	ar	ar	PROPN
eurjchem-1346	263	31	)	)	PUNCT
eurjchem-1346	263	32	,	,	PUNCT
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eurjchem-1346	263	34	(	(	PUNCT
eurjchem-1346	263	35	d	d	PROPN
eurjchem-1346	263	36	,	,	PUNCT
eurjchem-1346	263	37	j	j	PROPN
eurjchem-1346	263	38	=	=	SYM
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eurjchem-1346	263	41	,	,	PUNCT
eurjchem-1346	263	42	1h	1h	NUM
eurjchem-1346	263	43	,	,	PUNCT
eurjchem-1346	263	44	h‐9	h‐9	ADP
eurjchem-1346	263	45	ar	ar	PROPN
eurjchem-1346	263	46	)	)	PUNCT
eurjchem-1346	263	47	,	,	PUNCT
eurjchem-1346	263	48	7.56	7.56	NUM
eurjchem-1346	263	49	(	(	PUNCT
eurjchem-1346	263	50	d	d	PROPN
eurjchem-1346	263	51	,	,	PUNCT
eurjchem-1346	263	52	j	j	PROPN
eurjchem-1346	263	53	=	=	SYM
eurjchem-1346	263	54	8.1	8.1	NUM
eurjchem-1346	263	55	hz	hz	NOUN
eurjchem-1346	263	56	,	,	PUNCT
eurjchem-1346	263	57	1h	1h	NUM
eurjchem-1346	263	58	,	,	PUNCT
eurjchem-1346	263	59	h‐7ar	h‐7ar	NOUN
eurjchem-1346	263	60	)	)	PUNCT
eurjchem-1346	263	61	,	,	PUNCT
eurjchem-1346	263	62	7.91‐8.10	7.91‐8.10	NUM
eurjchem-1346	263	63	(	(	PUNCT
eurjchem-1346	263	64	m	m	PROPN
eurjchem-1346	263	65	,	,	PUNCT
eurjchem-1346	263	66	4h	4h	NUM
eurjchem-1346	263	67	,	,	PUNCT
eurjchem-1346	263	68	h‐2	h‐2	X
eurjchem-1346	263	69	’	'	PUNCT
eurjchem-1346	263	70	,	,	PUNCT
eurjchem-1346	263	71	3	3	NUM
eurjchem-1346	263	72	’	'	PUNCT
eurjchem-1346	263	73	,	,	PUNCT
eurjchem-1346	263	74	5	5	NUM
eurjchem-1346	263	75	’	'	PUNCT
eurjchem-1346	263	76	,	,	PUNCT
eurjchem-1346	263	77	6	6	NUM
eurjchem-1346	263	78	’	'	PUNCT
eurjchem-1346	263	79	ar	ar	NOUN
eurjchem-1346	263	80	)	)	PUNCT
eurjchem-1346	263	81	,	,	PUNCT
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eurjchem-1346	263	83	(	(	PUNCT
eurjchem-1346	263	84	s	s	PROPN
eurjchem-1346	263	85	,	,	PUNCT
eurjchem-1346	263	86	1h	1h	NUM
eurjchem-1346	263	87	,	,	PUNCT
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eurjchem-1346	263	89	,	,	PUNCT
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eurjchem-1346	263	91	with	with	ADP
eurjchem-1346	263	92	d2o	d2o	NOUN
eurjchem-1346	263	93	)	)	PUNCT
eurjchem-1346	263	94	,	,	PUNCT
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eurjchem-1346	263	96	(	(	PUNCT
eurjchem-1346	263	97	s	s	PROPN
eurjchem-1346	263	98	,	,	PUNCT
eurjchem-1346	263	99	1h	1h	NUM
eurjchem-1346	263	100	,	,	PUNCT
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eurjchem-1346	263	102	,	,	PUNCT
eurjchem-1346	263	103	exchanged	exchange	VERB
eurjchem-1346	263	104	with	with	ADP
eurjchem-1346	263	105	d2o	d2o	NOUN
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eurjchem-1346	263	107	.	.	PUNCT
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eurjchem-1346	264	2	.	.	PUNCT
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eurjchem-1346	264	4	.	.	PUNCT
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eurjchem-1346	265	3	:	:	PUNCT
eurjchem-1346	265	4	c	c	X
eurjchem-1346	265	5	,	,	PUNCT
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eurjchem-1346	265	8	h	h	NOUN
eurjchem-1346	265	9	,	,	PUNCT
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eurjchem-1346	265	11	;	;	PUNCT
eurjchem-1346	265	12	n	n	CCONJ
eurjchem-1346	265	13	,	,	PUNCT
eurjchem-1346	265	14	26.08	26.08	NUM
eurjchem-1346	265	15	.	.	PUNCT
eurjchem-1346	265	16	found	find	VERB
eurjchem-1346	265	17	:	:	PUNCT
eurjchem-1346	266	1	c	c	X
eurjchem-1346	266	2	,	,	PUNCT
eurjchem-1346	266	3	56.03	56.03	NUM
eurjchem-1346	266	4	;	;	PUNCT
eurjchem-1346	266	5	h	h	NOUN
eurjchem-1346	266	6	,	,	PUNCT
eurjchem-1346	266	7	3.17	3.17	NUM
eurjchem-1346	266	8	;	;	PUNCT
eurjchem-1346	266	9	n	n	CCONJ
eurjchem-1346	266	10	,	,	PUNCT
eurjchem-1346	266	11	26.32	26.32	NUM
eurjchem-1346	266	12	%	%	NOUN
eurjchem-1346	266	13	.	.	PUNCT
eurjchem-1346	267	1	4‐(4‐methoxyphenyl)‐2	4‐(4‐methoxyphenyl)‐2	NUM
eurjchem-1346	267	2	,	,	PUNCT
eurjchem-1346	267	3	5	5	NUM
eurjchem-1346	267	4	,	,	PUNCT
eurjchem-1346	267	5	10	10	NUM
eurjchem-1346	267	6	,	,	PUNCT
eurjchem-1346	267	7	11‐tetrahydropyrido[2,3‐g	11‐tetrahydropyrido[2,3‐g	NUM
eurjchem-1346	267	8	]	]	X
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eurjchem-1346	267	10	(	(	PUNCT
eurjchem-1346	267	11	6d	6d	NUM
eurjchem-1346	267	12	):	):	PUNCT
eurjchem-1346	267	13	yield	yield	NOUN
eurjchem-1346	267	14	:	:	PUNCT
eurjchem-1346	267	15	66	66	NUM
eurjchem-1346	267	16	%	%	NOUN
eurjchem-1346	267	17	.	.	PUNCT
eurjchem-1346	268	1	m.p	m.p	PROPN
eurjchem-1346	268	2	.	.	PROPN
eurjchem-1346	268	3	:	:	PUNCT
eurjchem-1346	269	1	229‐	229‐	NUM
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eurjchem-1346	269	3	°	°	NOUN
eurjchem-1346	269	4	c	c	NOUN
eurjchem-1346	269	5	.	.	PUNCT
eurjchem-1346	270	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	270	2	(	(	PUNCT
eurjchem-1346	270	3	kbr	kbr	PROPN
eurjchem-1346	270	4	,	,	PUNCT
eurjchem-1346	270	5			PROPN
eurjchem-1346	270	6	,	,	PUNCT
eurjchem-1346	270	7	cm‐1	cm‐1	PROPN
eurjchem-1346	270	8	):	):	PUNCT
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eurjchem-1346	270	10	,	,	PUNCT
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eurjchem-1346	270	12	(	(	PUNCT
eurjchem-1346	270	13	2nh	2nh	NOUN
eurjchem-1346	270	14	)	)	PUNCT
eurjchem-1346	270	15	,	,	PUNCT
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eurjchem-1346	270	17	(	(	PUNCT
eurjchem-1346	270	18	ch	ch	PROPN
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eurjchem-1346	270	20	)	)	PUNCT
eurjchem-1346	270	21	,	,	PUNCT
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eurjchem-1346	270	23	,	,	PUNCT
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eurjchem-1346	270	25	(	(	PUNCT
eurjchem-1346	270	26	ch	ch	NOUN
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eurjchem-1346	270	28	)	)	PUNCT
eurjchem-1346	270	29	,	,	PUNCT
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eurjchem-1346	270	31	(	(	PUNCT
eurjchem-1346	270	32	c	c	NOUN
eurjchem-1346	270	33	=	=	NOUN
eurjchem-1346	270	34	o	o	NOUN
eurjchem-1346	270	35	)	)	PUNCT
eurjchem-1346	270	36	,	,	PUNCT
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eurjchem-1346	270	38	,	,	PUNCT
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eurjchem-1346	270	40	,	,	PUNCT
eurjchem-1346	270	41	1575	1575	NUM
eurjchem-1346	270	42	,	,	PUNCT
eurjchem-1346	270	43	1558	1558	NUM
eurjchem-1346	270	44	,	,	PUNCT
eurjchem-1346	270	45	1508	1508	NUM
eurjchem-1346	270	46	(	(	PUNCT
eurjchem-1346	270	47	c	c	NOUN
eurjchem-1346	270	48	=	=	SYM
eurjchem-1346	270	49	n	n	X
eurjchem-1346	270	50	,	,	PUNCT
eurjchem-1346	270	51	nh	nh	PROPN
eurjchem-1346	270	52	,	,	PUNCT
eurjchem-1346	270	53	c	c	X
eurjchem-1346	270	54	=	=	SYM
eurjchem-1346	270	55	c	c	NOUN
eurjchem-1346	270	56	)	)	PUNCT
eurjchem-1346	270	57	.	.	PUNCT
eurjchem-1346	271	1	1h	1h	NUM
eurjchem-1346	271	2	nmr	nmr	NOUN
eurjchem-1346	271	3	(	(	PUNCT
eurjchem-1346	271	4	300	300	NUM
eurjchem-1346	271	5	mhz	mhz	NOUN
eurjchem-1346	271	6	,	,	PUNCT
eurjchem-1346	271	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	271	8	,	,	PUNCT
eurjchem-1346	271	9	δ	δ	PROPN
eurjchem-1346	271	10	,	,	PUNCT
eurjchem-1346	271	11	ppm	ppm	NOUN
eurjchem-1346	271	12	):	):	PUNCT
eurjchem-1346	271	13	3.72	3.72	NUM
eurjchem-1346	271	14	(	(	PUNCT
eurjchem-1346	271	15	s	s	PROPN
eurjchem-1346	271	16	,	,	PUNCT
eurjchem-1346	271	17	3h	3h	NUM
eurjchem-1346	271	18	,	,	PUNCT
eurjchem-1346	271	19	och3	och3	ADJ
eurjchem-1346	271	20	)	)	PUNCT
eurjchem-1346	271	21	,	,	PUNCT
eurjchem-1346	271	22	5.82	5.82	NUM
eurjchem-1346	271	23	(	(	PUNCT
eurjchem-1346	271	24	s	s	PROPN
eurjchem-1346	271	25	,	,	PUNCT
eurjchem-1346	271	26	1h	1h	NUM
eurjchem-1346	271	27	,	,	PUNCT
eurjchem-1346	271	28	h‐1	h‐1	PROPN
eurjchem-1346	271	29	ar	ar	PROPN
eurjchem-1346	271	30	)	)	PUNCT
eurjchem-1346	271	31	,	,	PUNCT
eurjchem-1346	271	32	6.54	6.54	NUM
eurjchem-1346	271	33	(	(	PUNCT
eurjchem-1346	271	34	t	t	PROPN
eurjchem-1346	271	35	,	,	PUNCT
eurjchem-1346	271	36	1h	1h	NUM
eurjchem-1346	271	37	,	,	PUNCT
eurjchem-1346	271	38	h‐8	h‐8	PROPN
eurjchem-1346	271	39	ar	ar	PROPN
eurjchem-1346	271	40	)	)	PUNCT
eurjchem-1346	271	41	,	,	PUNCT
eurjchem-1346	271	42	6.96	6.96	NUM
eurjchem-1346	271	43	(	(	PUNCT
eurjchem-1346	271	44	d	d	NOUN
eurjchem-1346	271	45	,	,	PUNCT
eurjchem-1346	271	46	j	j	PROPN
eurjchem-1346	271	47	=	=	SYM
eurjchem-1346	271	48	6.0	6.0	NUM
eurjchem-1346	271	49	hz	hz	NOUN
eurjchem-1346	271	50	,	,	PUNCT
eurjchem-1346	271	51	1h	1h	NUM
eurjchem-1346	271	52	,	,	PUNCT
eurjchem-1346	271	53	h‐9	h‐9	ADP
eurjchem-1346	271	54	ar	ar	PROPN
eurjchem-1346	271	55	)	)	PUNCT
eurjchem-1346	271	56	,	,	PUNCT
eurjchem-1346	271	57	7.03‐7.40	7.03‐7.40	PROPN
eurjchem-1346	271	58	(	(	PUNCT
eurjchem-1346	271	59	m	m	PROPN
eurjchem-1346	271	60	,	,	PUNCT
eurjchem-1346	271	61	4h	4h	NUM
eurjchem-1346	271	62	,	,	PUNCT
eurjchem-1346	271	63	h‐2	h‐2	X
eurjchem-1346	271	64	’	'	PUNCT
eurjchem-1346	271	65	,	,	PUNCT
eurjchem-1346	271	66	3	3	NUM
eurjchem-1346	271	67	’	'	PUNCT
eurjchem-1346	271	68	,	,	PUNCT
eurjchem-1346	271	69	5	5	NUM
eurjchem-1346	271	70	’	'	PUNCT
eurjchem-1346	271	71	,	,	PUNCT
eurjchem-1346	271	72	6	6	NUM
eurjchem-1346	271	73	’	'	PUNCT
eurjchem-1346	271	74	ar	ar	NOUN
eurjchem-1346	271	75	)	)	PUNCT
eurjchem-1346	271	76	,	,	PUNCT
eurjchem-1346	271	77	7.67	7.67	NUM
eurjchem-1346	271	78	(	(	PUNCT
eurjchem-1346	271	79	d	d	PROPN
eurjchem-1346	271	80	,	,	PUNCT
eurjchem-1346	271	81	j	j	PROPN
eurjchem-1346	272	1	=	=	SYM
eurjchem-1346	272	2	7.3	7.3	NUM
eurjchem-1346	272	3	hz	hz	NOUN
eurjchem-1346	272	4	,	,	PUNCT
eurjchem-1346	272	5	1h	1h	NUM
eurjchem-1346	272	6	,	,	PUNCT
eurjchem-1346	272	7	h‐7	h‐7	PROPN
eurjchem-1346	272	8	ar	ar	PROPN
eurjchem-1346	272	9	)	)	PUNCT
eurjchem-1346	272	10	,	,	PUNCT
eurjchem-1346	272	11	11.33	11.33	NUM
eurjchem-1346	272	12	(	(	PUNCT
eurjchem-1346	272	13	s	s	PROPN
eurjchem-1346	272	14	,	,	PUNCT
eurjchem-1346	272	15	1h	1h	NUM
eurjchem-1346	272	16	,	,	PUNCT
eurjchem-1346	272	17	nh	nh	PROPN
eurjchem-1346	272	18	,	,	PUNCT
eurjchem-1346	272	19	exchanged	exchange	VERB
eurjchem-1346	272	20	with	with	ADP
eurjchem-1346	272	21	d2o	d2o	NOUN
eurjchem-1346	272	22	)	)	PUNCT
eurjchem-1346	272	23	,	,	PUNCT
eurjchem-1346	272	24	11.51	11.51	NUM
eurjchem-1346	272	25	(	(	PUNCT
eurjchem-1346	272	26	s	s	PROPN
eurjchem-1346	272	27	,	,	PUNCT
eurjchem-1346	272	28	1h	1h	NUM
eurjchem-1346	272	29	,	,	PUNCT
eurjchem-1346	272	30	nh	nh	PROPN
eurjchem-1346	272	31	,	,	PUNCT
eurjchem-1346	272	32	exchanged	exchange	VERB
eurjchem-1346	272	33	with	with	ADP
eurjchem-1346	272	34	d2o	d2o	NOUN
eurjchem-1346	272	35	)	)	PUNCT
eurjchem-1346	272	36	.	.	PUNCT
eurjchem-1346	273	1	2.1.7	2.1.7	X
eurjchem-1346	273	2	.	.	PUNCT
eurjchem-1346	273	3	general	general	ADJ
eurjchem-1346	273	4	procedure	procedure	NOUN
eurjchem-1346	273	5	for	for	ADP
eurjchem-1346	273	6	synthesis	synthesis	NOUN
eurjchem-1346	273	7	of	of	ADP
eurjchem-1346	273	8	3‐(2,5‐dioxopyrrol	3‐(2,5‐dioxopyrrol	NUM
eurjchem-1346	273	9	(	(	PUNCT
eurjchem-1346	273	10	or	or	CCONJ
eurjchem-1346	273	11	pyroliden)‐1‐yl)aminomethylpyrido[2,3‐b]pyrazin‐2	pyroliden)‐1‐yl)aminomethylpyrido[2,3‐b]pyrazin‐2	NUM
eurjchem-1346	273	12	(	(	PUNCT
eurjchem-1346	273	13	1h)ones	1h)ones	NUM
eurjchem-1346	273	14	(	(	PUNCT
eurjchem-1346	273	15	7a‐c	7a‐c	NOUN
eurjchem-1346	273	16	)	)	PUNCT
eurjchem-1346	273	17	appropriate	appropriate	ADJ
eurjchem-1346	273	18	cyclic	cyclic	ADJ
eurjchem-1346	273	19	acid	acid	NOUN
eurjchem-1346	273	20	anhydride	anhydride	NOUN
eurjchem-1346	273	21	(	(	PUNCT
eurjchem-1346	273	22	0.005	0.005	NUM
eurjchem-1346	273	23	mol	mol	NOUN
eurjchem-1346	273	24	)	)	PUNCT
eurjchem-1346	273	25	was	be	AUX
eurjchem-1346	273	26	added	add	VERB
eurjchem-1346	273	27	to	to	ADP
eurjchem-1346	273	28	solution	solution	NOUN
eurjchem-1346	273	29	of	of	ADP
eurjchem-1346	273	30	hydrazine	hydrazine	NOUN
eurjchem-1346	273	31	compound	compound	NOUN
eurjchem-1346	273	32	4	4	NUM
eurjchem-1346	273	33	(	(	PUNCT
eurjchem-1346	273	34	0.96	0.96	NUM
eurjchem-1346	273	35	g	g	NOUN
eurjchem-1346	273	36	,	,	PUNCT
eurjchem-1346	273	37	0.005	0.005	NUM
eurjchem-1346	273	38	mol	mol	NOUN
eurjchem-1346	273	39	)	)	PUNCT
eurjchem-1346	273	40	in	in	ADP
eurjchem-1346	273	41	glacial	glacial	ADJ
eurjchem-1346	273	42	acetic	acetic	ADJ
eurjchem-1346	273	43	acid	acid	NOUN
eurjchem-1346	273	44	(	(	PUNCT
eurjchem-1346	273	45	10	10	NUM
eurjchem-1346	273	46	ml	ml	NOUN
eurjchem-1346	273	47	)	)	PUNCT
eurjchem-1346	273	48	and	and	CCONJ
eurjchem-1346	273	49	refluxed	refluxe	VERB
eurjchem-1346	273	50	for	for	ADP
eurjchem-1346	273	51	6	6	NUM
eurjchem-1346	273	52	h.	h.	NOUN
eurjchem-1346	273	53	after	after	ADP
eurjchem-1346	273	54	cooling	cool	VERB
eurjchem-1346	273	55	,	,	PUNCT
eurjchem-1346	273	56	the	the	DET
eurjchem-1346	273	57	mixture	mixture	NOUN
eurjchem-1346	273	58	was	be	AUX
eurjchem-1346	273	59	poured	pour	VERB
eurjchem-1346	273	60	onto	onto	ADP
eurjchem-1346	273	61	crushed	crushed	ADJ
eurjchem-1346	273	62	ice	ice	NOUN
eurjchem-1346	273	63	(	(	PUNCT
eurjchem-1346	273	64	30	30	NUM
eurjchem-1346	273	65	g	g	NOUN
eurjchem-1346	273	66	)	)	PUNCT
eurjchem-1346	273	67	.	.	PUNCT
eurjchem-1346	274	1	the	the	DET
eurjchem-1346	274	2	formed	form	VERB
eurjchem-1346	274	3	precipitate	precipitate	NOUN
eurjchem-1346	274	4	was	be	AUX
eurjchem-1346	274	5	filtered	filter	VERB
eurjchem-1346	274	6	,	,	PUNCT
eurjchem-1346	274	7	washed	wash	VERB
eurjchem-1346	274	8	with	with	ADP
eurjchem-1346	274	9	water	water	NOUN
eurjchem-1346	274	10	(	(	PUNCT
eurjchem-1346	274	11	5	5	NUM
eurjchem-1346	274	12	ml	ml	NOUN
eurjchem-1346	274	13	)	)	PUNCT
eurjchem-1346	274	14	and	and	CCONJ
eurjchem-1346	274	15	dried	dry	VERB
eurjchem-1346	274	16	.	.	PUNCT
eurjchem-1346	275	1	the	the	DET
eurjchem-1346	275	2	crude	crude	ADJ
eurjchem-1346	275	3	product	product	NOUN
eurjchem-1346	275	4	was	be	AUX
eurjchem-1346	275	5	crystalized	crystalize	VERB
eurjchem-1346	275	6	from	from	ADP
eurjchem-1346	275	7	ethanol	ethanol	NOUN
eurjchem-1346	275	8	(	(	PUNCT
eurjchem-1346	275	9	scheme	scheme	NOUN
eurjchem-1346	275	10	1	1	NUM
eurjchem-1346	275	11	)	)	PUNCT
eurjchem-1346	275	12	.	.	PUNCT
eurjchem-1346	276	1	3‐(2	3‐(2	NUM
eurjchem-1346	276	2	,	,	PUNCT
eurjchem-1346	276	3	5‐dioxopyrroliden‐1‐yl)aminomethylpyrido[2	5‐dioxopyrroliden‐1‐yl)aminomethylpyrido[2	NUM
eurjchem-1346	276	4	,	,	PUNCT
eurjchem-1346	276	5	3‐b	3‐b	NUM
eurjchem-1346	276	6	]	]	PUNCT
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eurjchem-1346	276	8	(	(	PUNCT
eurjchem-1346	276	9	7a	7a	NUM
eurjchem-1346	276	10	):	):	PUNCT
eurjchem-1346	276	11	yield	yield	NOUN
eurjchem-1346	276	12	:	:	PUNCT
eurjchem-1346	276	13	86	86	NUM
eurjchem-1346	276	14	%	%	NOUN
eurjchem-1346	276	15	.	.	PUNCT
eurjchem-1346	277	1	m.p	m.p	PROPN
eurjchem-1346	277	2	.	.	PROPN
eurjchem-1346	277	3	:	:	PUNCT
eurjchem-1346	277	4	215‐217	215‐217	NUM
eurjchem-1346	277	5	°	°	PROPN
eurjchem-1346	277	6	c	c	NOUN
eurjchem-1346	277	7	.	.	PUNCT
eurjchem-1346	278	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	278	2	(	(	PUNCT
eurjchem-1346	278	3	kbr	kbr	PROPN
eurjchem-1346	278	4	,	,	PUNCT
eurjchem-1346	278	5			PROPN
eurjchem-1346	278	6	,	,	PUNCT
eurjchem-1346	278	7	cm‐1	cm‐1	PROPN
eurjchem-1346	278	8	):	):	PUNCT
eurjchem-1346	278	9	3410	3410	NUM
eurjchem-1346	278	10	,	,	PUNCT
eurjchem-1346	278	11	3396	3396	NUM
eurjchem-1346	278	12	(	(	PUNCT
eurjchem-1346	278	13	2nh	2nh	NOUN
eurjchem-1346	278	14	)	)	PUNCT
eurjchem-1346	278	15	,	,	PUNCT
eurjchem-1346	278	16	3026	3026	NUM
eurjchem-1346	278	17	(	(	PUNCT
eurjchem-1346	278	18	ch	ch	PROPN
eurjchem-1346	278	19	ar	ar	PROPN
eurjchem-1346	278	20	)	)	PUNCT
eurjchem-1346	278	21	,	,	PUNCT
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eurjchem-1346	278	23	,	,	PUNCT
eurjchem-1346	278	24	2848	2848	NUM
eurjchem-1346	278	25	(	(	PUNCT
eurjchem-1346	278	26	ch	ch	NOUN
eurjchem-1346	278	27	aliph	aliph	PROPN
eurjchem-1346	278	28	)	)	PUNCT
eurjchem-1346	278	29	,	,	PUNCT
eurjchem-1346	278	30	1668	1668	NUM
eurjchem-1346	278	31	(	(	PUNCT
eurjchem-1346	278	32	3c	3c	NUM
eurjchem-1346	278	33	=	=	SYM
eurjchem-1346	278	34	o	o	NOUN
eurjchem-1346	278	35	)	)	PUNCT
eurjchem-1346	278	36	,	,	PUNCT
eurjchem-1346	278	37	1635	1635	NUM
eurjchem-1346	278	38	,	,	PUNCT
eurjchem-1346	278	39	1602	1602	NUM
eurjchem-1346	278	40	,	,	PUNCT
eurjchem-1346	278	41	1589	1589	NUM
eurjchem-1346	278	42	,	,	PUNCT
eurjchem-1346	278	43	1558	1558	NUM
eurjchem-1346	278	44	,	,	PUNCT
eurjchem-1346	278	45	1521	1521	NUM
eurjchem-1346	278	46	(	(	PUNCT
eurjchem-1346	278	47	c	c	NOUN
eurjchem-1346	278	48	=	=	SYM
eurjchem-1346	278	49	n	n	X
eurjchem-1346	278	50	,	,	PUNCT
eurjchem-1346	278	51	nh	nh	PROPN
eurjchem-1346	278	52	,	,	PUNCT
eurjchem-1346	278	53	c	c	X
eurjchem-1346	278	54	=	=	SYM
eurjchem-1346	278	55	c	c	NOUN
eurjchem-1346	278	56	)	)	PUNCT
eurjchem-1346	278	57	.	.	PUNCT
eurjchem-1346	279	1	1h	1h	NUM
eurjchem-1346	279	2	nmr	nmr	NOUN
eurjchem-1346	279	3	(	(	PUNCT
eurjchem-1346	279	4	300	300	NUM
eurjchem-1346	279	5	mhz	mhz	NOUN
eurjchem-1346	279	6	,	,	PUNCT
eurjchem-1346	279	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	279	8	,	,	PUNCT
eurjchem-1346	279	9	δ	δ	PROPN
eurjchem-1346	279	10	,	,	PUNCT
eurjchem-1346	279	11	ppm	ppm	NUM
eurjchem-1346	279	12	):	):	PUNCT
eurjchem-1346	279	13	2.56	2.56	NUM
eurjchem-1346	279	14	(	(	PUNCT
eurjchem-1346	279	15	s	s	PROPN
eurjchem-1346	279	16	,	,	PUNCT
eurjchem-1346	279	17	2h	2h	NUM
eurjchem-1346	279	18	,	,	PUNCT
eurjchem-1346	279	19	ch2	ch2	PROPN
eurjchem-1346	279	20	)	)	PUNCT
eurjchem-1346	279	21	,	,	PUNCT
eurjchem-1346	279	22	3.11	3.11	NUM
eurjchem-1346	279	23	(	(	PUNCT
eurjchem-1346	279	24	t	t	PROPN
eurjchem-1346	279	25	,	,	PUNCT
eurjchem-1346	279	26	4h	4h	NUM
eurjchem-1346	279	27	,	,	PUNCT
eurjchem-1346	279	28	ch2‐ch2	ch2‐ch2	PROPN
eurjchem-1346	279	29	)	)	PUNCT
eurjchem-1346	279	30	,	,	PUNCT
eurjchem-1346	279	31	7.22	7.22	NUM
eurjchem-1346	279	32	(	(	PUNCT
eurjchem-1346	279	33	d	d	PROPN
eurjchem-1346	279	34	,	,	PUNCT
eurjchem-1346	279	35	j	j	PROPN
eurjchem-1346	279	36	=	=	SYM
eurjchem-1346	279	37	6.1	6.1	NUM
eurjchem-1346	279	38	hz	hz	NOUN
eurjchem-1346	279	39	,	,	PUNCT
eurjchem-1346	279	40	1h	1h	NUM
eurjchem-1346	279	41	,	,	PUNCT
eurjchem-1346	279	42	h‐8ar	h‐8ar	NOUN
eurjchem-1346	279	43	)	)	PUNCT
eurjchem-1346	279	44	,	,	PUNCT
eurjchem-1346	279	45	7.58	7.58	NUM
eurjchem-1346	279	46	(	(	PUNCT
eurjchem-1346	279	47	t	t	PROPN
eurjchem-1346	279	48	,	,	PUNCT
eurjchem-1346	279	49	1h	1h	NUM
eurjchem-1346	279	50	,	,	PUNCT
eurjchem-1346	279	51	h‐7ar	h‐7ar	NOUN
eurjchem-1346	279	52	)	)	PUNCT
eurjchem-1346	279	53	,	,	PUNCT
eurjchem-1346	279	54	8.18	8.18	NUM
eurjchem-1346	279	55	(	(	PUNCT
eurjchem-1346	279	56	d	d	NOUN
eurjchem-1346	279	57	,	,	PUNCT
eurjchem-1346	279	58	j	j	PROPN
eurjchem-1346	279	59	=	=	SYM
eurjchem-1346	279	60	6.4	6.4	NUM
eurjchem-1346	279	61	hz	hz	NOUN
eurjchem-1346	279	62	,	,	PUNCT
eurjchem-1346	279	63	1h	1h	NUM
eurjchem-1346	279	64	,	,	PUNCT
eurjchem-1346	279	65	h‐6ar	h‐6ar	NOUN
eurjchem-1346	279	66	)	)	PUNCT
eurjchem-1346	279	67	,	,	PUNCT
eurjchem-1346	279	68	11.23	11.23	NUM
eurjchem-1346	279	69	(	(	PUNCT
eurjchem-1346	279	70	s	s	PROPN
eurjchem-1346	279	71	,	,	PUNCT
eurjchem-1346	279	72	1h	1h	NUM
eurjchem-1346	279	73	,	,	PUNCT
eurjchem-1346	279	74	nh	nh	PROPN
eurjchem-1346	279	75	,	,	PUNCT
eurjchem-1346	279	76	exchanged	exchange	VERB
eurjchem-1346	279	77	with	with	ADP
eurjchem-1346	279	78	d2o	d2o	NOUN
eurjchem-1346	279	79	)	)	PUNCT
eurjchem-1346	279	80	,	,	PUNCT
eurjchem-1346	279	81	11.44	11.44	NUM
eurjchem-1346	279	82	(	(	PUNCT
eurjchem-1346	279	83	s	s	PROPN
eurjchem-1346	279	84	,	,	PUNCT
eurjchem-1346	279	85	1h	1h	NUM
eurjchem-1346	279	86	,	,	PUNCT
eurjchem-1346	279	87	nh	nh	PROPN
eurjchem-1346	279	88	,	,	PUNCT
eurjchem-1346	279	89	exchanged	exchange	VERB
eurjchem-1346	279	90	with	with	ADP
eurjchem-1346	279	91	d2o	d2o	NOUN
eurjchem-1346	279	92	)	)	PUNCT
eurjchem-1346	279	93	.	.	PUNCT
eurjchem-1346	280	1	anal	anal	PROPN
eurjchem-1346	280	2	.	.	PUNCT
eurjchem-1346	280	3	calcd	calcd	NOUN
eurjchem-1346	280	4	.	.	PUNCT
eurjchem-1346	281	1	for	for	ADP
eurjchem-1346	281	2	c12h11n5o3	c12h11n5o3	PROPN
eurjchem-1346	281	3	:	:	PUNCT
eurjchem-1346	281	4	c	c	NOUN
eurjchem-1346	281	5	,	,	PUNCT
eurjchem-1346	281	6	52.75	52.75	NUM
eurjchem-1346	281	7	;	;	PUNCT
eurjchem-1346	281	8	h	h	NOUN
eurjchem-1346	281	9	,	,	PUNCT
eurjchem-1346	281	10	4.06	4.06	NUM
eurjchem-1346	281	11	;	;	PUNCT
eurjchem-1346	281	12	n	n	CCONJ
eurjchem-1346	281	13	,	,	PUNCT
eurjchem-1346	281	14	25.63	25.63	NUM
eurjchem-1346	281	15	.	.	PUNCT
eurjchem-1346	281	16	found	find	VERB
eurjchem-1346	281	17	:	:	PUNCT
eurjchem-1346	282	1	c	c	X
eurjchem-1346	282	2	,	,	PUNCT
eurjchem-1346	282	3	52.84	52.84	NUM
eurjchem-1346	282	4	;	;	PUNCT
eurjchem-1346	282	5	h	h	NOUN
eurjchem-1346	282	6	,	,	PUNCT
eurjchem-1346	282	7	4.11	4.11	NUM
eurjchem-1346	282	8	;	;	PUNCT
eurjchem-1346	282	9	n	n	CCONJ
eurjchem-1346	282	10	,	,	PUNCT
eurjchem-1346	282	11	25.89	25.89	NUM
eurjchem-1346	282	12	%	%	NOUN
eurjchem-1346	282	13	.	.	PUNCT
eurjchem-1346	283	1	3‐(2,5‐dioxo‐2,5‐dihydro‐1h‐pyrrol‐1‐yl)aminomethylpyrido	3‐(2,5‐dioxo‐2,5‐dihydro‐1h‐pyrrol‐1‐yl)aminomethylpyrido	NUM
eurjchem-1346	284	1	[	[	X
eurjchem-1346	284	2	2,3‐b]pyrazin‐2(1h)one	2,3‐b]pyrazin‐2(1h)one	NUM
eurjchem-1346	284	3	(	(	PUNCT
eurjchem-1346	284	4	7b	7b	NUM
eurjchem-1346	284	5	):	):	PUNCT
eurjchem-1346	284	6	yield	yield	NOUN
eurjchem-1346	284	7	:	:	PUNCT
eurjchem-1346	284	8	85	85	NUM
eurjchem-1346	284	9	%	%	NOUN
eurjchem-1346	284	10	.	.	PUNCT
eurjchem-1346	285	1	m.p	m.p	PROPN
eurjchem-1346	285	2	.	.	PROPN
eurjchem-1346	285	3	:	:	PUNCT
eurjchem-1346	286	1	212‐215	212‐215	NUM
eurjchem-1346	286	2	°	°	NUM
eurjchem-1346	286	3	c	c	X
eurjchem-1346	286	4	.	.	PUNCT
eurjchem-1346	287	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	287	2	(	(	PUNCT
eurjchem-1346	287	3	kbr	kbr	PROPN
eurjchem-1346	287	4	,	,	PUNCT
eurjchem-1346	287	5			PROPN
eurjchem-1346	287	6	,	,	PUNCT
eurjchem-1346	287	7	cm‐1	cm‐1	PROPN
eurjchem-1346	287	8	):	):	PUNCT
eurjchem-1346	287	9	3421	3421	NUM
eurjchem-1346	287	10	,	,	PUNCT
eurjchem-1346	287	11	3398	3398	NUM
eurjchem-1346	287	12	(	(	PUNCT
eurjchem-1346	287	13	2nh	2nh	PROPN
eurjchem-1346	287	14	)	)	PUNCT
eurjchem-1346	287	15	,	,	PUNCT
eurjchem-1346	287	16	3030	3030	NUM
eurjchem-1346	287	17	(	(	PUNCT
eurjchem-1346	287	18	ch	ch	PROPN
eurjchem-1346	287	19	ar	ar	PROPN
eurjchem-1346	287	20	)	)	PUNCT
eurjchem-1346	287	21	,	,	PUNCT
eurjchem-1346	287	22	2964	2964	NUM
eurjchem-1346	287	23	,	,	PUNCT
eurjchem-1346	287	24	2848	2848	NUM
eurjchem-1346	287	25	(	(	PUNCT
eurjchem-1346	287	26	ch	ch	NOUN
eurjchem-1346	287	27	aliph	aliph	PROPN
eurjchem-1346	287	28	)	)	PUNCT
eurjchem-1346	287	29	,	,	PUNCT
eurjchem-1346	287	30	1668	1668	NUM
eurjchem-1346	287	31	(	(	PUNCT
eurjchem-1346	287	32	3c	3c	NUM
eurjchem-1346	287	33	=	=	SYM
eurjchem-1346	287	34	o	o	NOUN
eurjchem-1346	287	35	)	)	PUNCT
eurjchem-1346	287	36	,	,	PUNCT
eurjchem-1346	287	37	1635	1635	NUM
eurjchem-1346	287	38	,	,	PUNCT
eurjchem-1346	287	39	1602	1602	NUM
eurjchem-1346	287	40	,	,	PUNCT
eurjchem-1346	287	41	1589	1589	NUM
eurjchem-1346	287	42	,	,	PUNCT
eurjchem-1346	287	43	1558	1558	NUM
eurjchem-1346	287	44	,	,	PUNCT
eurjchem-1346	287	45	1521	1521	NUM
eurjchem-1346	287	46	(	(	PUNCT
eurjchem-1346	287	47	c	c	NOUN
eurjchem-1346	287	48	=	=	SYM
eurjchem-1346	287	49	n	n	X
eurjchem-1346	287	50	,	,	PUNCT
eurjchem-1346	287	51	nh	nh	PROPN
eurjchem-1346	287	52	,	,	PUNCT
eurjchem-1346	287	53	c	c	X
eurjchem-1346	287	54	=	=	SYM
eurjchem-1346	287	55	c	c	NOUN
eurjchem-1346	287	56	)	)	PUNCT
eurjchem-1346	287	57	.	.	PUNCT
eurjchem-1346	288	1	1h	1h	NUM
eurjchem-1346	288	2	nmr	nmr	NOUN
eurjchem-1346	288	3	(	(	PUNCT
eurjchem-1346	288	4	400	400	NUM
eurjchem-1346	288	5	mhz	mhz	NOUN
eurjchem-1346	288	6	,	,	PUNCT
eurjchem-1346	288	7	dmso‐d6	dmso‐d6	PROPN
eurjchem-1346	288	8	,	,	PUNCT
eurjchem-1346	288	9	δ	δ	PROPN
eurjchem-1346	288	10	,	,	PUNCT
eurjchem-1346	288	11	ppm	ppm	NOUN
eurjchem-1346	288	12	):	):	PUNCT
eurjchem-1346	288	13	2.55	2.55	NUM
eurjchem-1346	288	14	(	(	PUNCT
eurjchem-1346	288	15	s	s	PROPN
eurjchem-1346	288	16	,	,	PUNCT
eurjchem-1346	288	17	2h	2h	NUM
eurjchem-1346	288	18	,	,	PUNCT
eurjchem-1346	288	19	ch2	ch2	PROPN
eurjchem-1346	288	20	)	)	PUNCT
eurjchem-1346	288	21	,	,	PUNCT
eurjchem-1346	288	22	5.11	5.11	NUM
eurjchem-1346	288	23	(	(	PUNCT
eurjchem-1346	288	24	d	d	PROPN
eurjchem-1346	288	25	,	,	PUNCT
eurjchem-1346	288	26	j	j	PROPN
eurjchem-1346	288	27	=	=	SYM
eurjchem-1346	288	28	8.7	8.7	NUM
eurjchem-1346	288	29	hz	hz	NOUN
eurjchem-1346	288	30	,	,	PUNCT
eurjchem-1346	288	31	2h	2h	NUM
eurjchem-1346	288	32	,	,	PUNCT
eurjchem-1346	288	33	ch	ch	NOUN
eurjchem-1346	288	34	=	=	NOUN
eurjchem-1346	288	35	ch	ch	NOUN
eurjchem-1346	288	36	)	)	PUNCT
eurjchem-1346	288	37	,	,	PUNCT
eurjchem-1346	288	38	7.21	7.21	NUM
eurjchem-1346	288	39	(	(	PUNCT
eurjchem-1346	288	40	d	d	PROPN
eurjchem-1346	288	41	,	,	PUNCT
eurjchem-1346	288	42	j	j	PROPN
eurjchem-1346	288	43	=	=	SYM
eurjchem-1346	288	44	6.3	6.3	NUM
eurjchem-1346	288	45	hz	hz	NOUN
eurjchem-1346	288	46	,	,	PUNCT
eurjchem-1346	288	47	1h	1h	NUM
eurjchem-1346	288	48	,	,	PUNCT
eurjchem-1346	288	49	h‐8ar	h‐8ar	NOUN
eurjchem-1346	288	50	)	)	PUNCT
eurjchem-1346	288	51	,	,	PUNCT
eurjchem-1346	288	52	7.50	7.50	NUM
eurjchem-1346	288	53	(	(	PUNCT
eurjchem-1346	288	54	t	t	PROPN
eurjchem-1346	288	55	,	,	PUNCT
eurjchem-1346	288	56	1h	1h	NUM
eurjchem-1346	288	57	,	,	PUNCT
eurjchem-1346	288	58	h‐7ar	h‐7ar	NOUN
eurjchem-1346	288	59	)	)	PUNCT
eurjchem-1346	288	60	,	,	PUNCT
eurjchem-1346	288	61	8.01	8.01	NUM
eurjchem-1346	288	62	(	(	PUNCT
eurjchem-1346	288	63	d	d	PROPN
eurjchem-1346	288	64	,	,	PUNCT
eurjchem-1346	288	65	j	j	PROPN
eurjchem-1346	288	66	=	=	SYM
eurjchem-1346	288	67	7.7	7.7	NUM
eurjchem-1346	288	68	hz	hz	NOUN
eurjchem-1346	288	69	,	,	PUNCT
eurjchem-1346	288	70	1h	1h	NUM
eurjchem-1346	288	71	,	,	PUNCT
eurjchem-1346	288	72	h‐6ar	h‐6ar	NOUN
eurjchem-1346	288	73	)	)	PUNCT
eurjchem-1346	288	74	,	,	PUNCT
eurjchem-1346	288	75	11.33	11.33	NUM
eurjchem-1346	288	76	(	(	PUNCT
eurjchem-1346	288	77	s	s	PROPN
eurjchem-1346	288	78	,	,	PUNCT
eurjchem-1346	288	79	1h	1h	NUM
eurjchem-1346	288	80	,	,	PUNCT
eurjchem-1346	288	81	nh	nh	PROPN
eurjchem-1346	288	82	,	,	PUNCT
eurjchem-1346	288	83	exchanged	exchange	VERB
eurjchem-1346	288	84	with	with	ADP
eurjchem-1346	288	85	d2o	d2o	NOUN
eurjchem-1346	288	86	)	)	PUNCT
eurjchem-1346	288	87	,	,	PUNCT
eurjchem-1346	288	88	11.49	11.49	NUM
eurjchem-1346	288	89	(	(	PUNCT
eurjchem-1346	288	90	s	s	PROPN
eurjchem-1346	288	91	,	,	PUNCT
eurjchem-1346	288	92	1h	1h	NUM
eurjchem-1346	288	93	,	,	PUNCT
eurjchem-1346	288	94	nh	nh	PROPN
eurjchem-1346	288	95	,	,	PUNCT
eurjchem-1346	288	96	exchanged	exchange	VERB
eurjchem-1346	288	97	with	with	ADP
eurjchem-1346	288	98	d2o	d2o	NOUN
eurjchem-1346	288	99	)	)	PUNCT
eurjchem-1346	288	100	.	.	PUNCT
eurjchem-1346	289	1	anal	anal	PROPN
eurjchem-1346	289	2	.	.	PUNCT
eurjchem-1346	289	3	calcd	calcd	NOUN
eurjchem-1346	289	4	.	.	PUNCT
eurjchem-1346	290	1	for	for	ADP
eurjchem-1346	290	2	c12h9n5o3	c12h9n5o3	NOUN
eurjchem-1346	290	3	:	:	PUNCT
eurjchem-1346	290	4	c	c	X
eurjchem-1346	290	5	,	,	PUNCT
eurjchem-1346	290	6	53.14	53.14	NUM
eurjchem-1346	290	7	;	;	PUNCT
eurjchem-1346	290	8	h	h	NOUN
eurjchem-1346	290	9	,	,	PUNCT
eurjchem-1346	290	10	3.34	3.34	NUM
eurjchem-1346	290	11	;	;	PUNCT
eurjchem-1346	290	12	n	n	CCONJ
eurjchem-1346	290	13	,	,	PUNCT
eurjchem-1346	290	14	25.82	25.82	NUM
eurjchem-1346	290	15	.	.	PUNCT
eurjchem-1346	290	16	found	find	VERB
eurjchem-1346	290	17	:	:	PUNCT
eurjchem-1346	291	1	c	c	X
eurjchem-1346	291	2	,	,	PUNCT
eurjchem-1346	291	3	53.22	53.22	NUM
eurjchem-1346	291	4	;	;	PUNCT
eurjchem-1346	291	5	h	h	NOUN
eurjchem-1346	291	6	,	,	PUNCT
eurjchem-1346	291	7	3.31	3.31	NUM
eurjchem-1346	291	8	;	;	PUNCT
eurjchem-1346	291	9	n	n	CCONJ
eurjchem-1346	291	10	,	,	PUNCT
eurjchem-1346	291	11	26.04	26.04	NUM
eurjchem-1346	291	12	%	%	NOUN
eurjchem-1346	291	13	.	.	PUNCT
eurjchem-1346	292	1	3‐(2	3‐(2	NUM
eurjchem-1346	292	2	,	,	PUNCT
eurjchem-1346	292	3	5‐dioxo‐2	5‐dioxo‐2	PRON
eurjchem-1346	292	4	,	,	PUNCT
eurjchem-1346	292	5	5‐dihydro‐1h‐benzo[c]pyrrol‐1‐yl)amino	5‐dihydro‐1h‐benzo[c]pyrrol‐1‐yl)amino	NUM
eurjchem-1346	292	6	methylpyrido[2,3‐b]pyrazin‐2(1h)one	methylpyrido[2,3‐b]pyrazin‐2(1h)one	X
eurjchem-1346	292	7	(	(	PUNCT
eurjchem-1346	292	8	7c	7c	NOUN
eurjchem-1346	292	9	):	):	PUNCT
eurjchem-1346	292	10	yield	yield	NOUN
eurjchem-1346	292	11	:	:	PUNCT
eurjchem-1346	292	12	86	86	NUM
eurjchem-1346	292	13	%	%	NOUN
eurjchem-1346	292	14	.	.	PUNCT
eurjchem-1346	293	1	m.p	m.p	PROPN
eurjchem-1346	293	2	.	.	PROPN
eurjchem-1346	293	3	:	:	PUNCT
eurjchem-1346	293	4	218‐221	218‐221	NUM
eurjchem-1346	293	5	°	°	SYM
eurjchem-1346	293	6	c	c	X
eurjchem-1346	293	7	.	.	PUNCT
eurjchem-1346	294	1	ft‐ir	ft‐ir	NOUN
eurjchem-1346	294	2	(	(	PUNCT
eurjchem-1346	294	3	kbr	kbr	PROPN
eurjchem-1346	294	4	,	,	PUNCT
eurjchem-1346	294	5			PROPN
eurjchem-1346	294	6	,	,	PUNCT
eurjchem-1346	294	7	cm‐1	cm‐1	PROPN
eurjchem-1346	294	8	):	):	PUNCT
eurjchem-1346	294	9	3446	3446	NUM
eurjchem-1346	294	10	,	,	PUNCT
eurjchem-1346	294	11	3395	3395	NUM
eurjchem-1346	294	12	(	(	PUNCT
eurjchem-1346	294	13	2nh	2nh	PROPN
eurjchem-1346	294	14	)	)	PUNCT
eurjchem-1346	294	15	,	,	PUNCT
eurjchem-1346	294	16	3010	3010	NUM
eurjchem-1346	294	17	(	(	PUNCT
eurjchem-1346	294	18	ch	ch	PROPN
eurjchem-1346	294	19	ar	ar	PROPN
eurjchem-1346	294	20	)	)	PUNCT
eurjchem-1346	294	21	,	,	PUNCT
eurjchem-1346	294	22	2966	2966	NUM
eurjchem-1346	294	23	,	,	PUNCT
eurjchem-1346	294	24	2854	2854	NUM
eurjchem-1346	294	25	(	(	PUNCT
eurjchem-1346	294	26	ch	ch	NOUN
eurjchem-1346	294	27	aliph	aliph	PROPN
eurjchem-1346	294	28	)	)	PUNCT
eurjchem-1346	294	29	,	,	PUNCT
eurjchem-1346	294	30	1683	1683	NUM
eurjchem-1346	294	31	(	(	PUNCT
eurjchem-1346	294	32	3c	3c	NUM
eurjchem-1346	294	33	=	=	SYM
eurjchem-1346	294	34	o	o	NOUN
eurjchem-1346	294	35	)	)	PUNCT
eurjchem-1346	294	36	,	,	PUNCT
eurjchem-1346	294	37	1637	1637	NUM
eurjchem-1346	294	38	,	,	PUNCT
eurjchem-1346	294	39	1602	1602	NUM
eurjchem-1346	294	40	,	,	PUNCT
eurjchem-1346	294	41	1587	1587	NUM
eurjchem-1346	294	42	,	,	PUNCT
eurjchem-1346	294	43	1568	1568	NUM
eurjchem-1346	294	44	,	,	PUNCT
eurjchem-1346	294	45	1541	1541	NUM
eurjchem-1346	294	46	,	,	PUNCT
eurjchem-1346	294	47	1521	1521	NUM
eurjchem-1346	294	48	(	(	PUNCT
eurjchem-1346	294	49	c	c	NOUN
eurjchem-1346	294	50	=	=	SYM
eurjchem-1346	294	51	n	n	X
eurjchem-1346	294	52	,	,	PUNCT
eurjchem-1346	294	53	nh	nh	PROPN
eurjchem-1346	294	54	,	,	PUNCT
eurjchem-1346	294	55	c	c	X
eurjchem-1346	294	56	=	=	SYM
eurjchem-1346	294	57	c	c	NOUN
eurjchem-1346	294	58	)	)	PUNCT
eurjchem-1346	294	59	.	.	PUNCT
eurjchem-1346	295	1	1h	1h	NUM
eurjchem-1346	295	2	nmr	nmr	NOUN
eurjchem-1346	295	3	(	(	PUNCT
eurjchem-1346	295	4	400	400	NUM
eurjchem-1346	295	5	mhz	mhz	NOUN
eurjchem-1346	295	6	,	,	PUNCT
eurjchem-1346	295	7	dmso‐	dmso‐	NUM
eurjchem-1346	295	8	d6	d6	NOUN
eurjchem-1346	295	9	,	,	PUNCT
eurjchem-1346	295	10	δ	δ	PROPN
eurjchem-1346	295	11	,	,	PUNCT
eurjchem-1346	295	12	ppm	ppm	NOUN
eurjchem-1346	295	13	):	):	PUNCT
eurjchem-1346	295	14	2.70	2.70	NUM
eurjchem-1346	295	15	(	(	PUNCT
eurjchem-1346	295	16	s	s	PROPN
eurjchem-1346	295	17	,	,	PUNCT
eurjchem-1346	295	18	2h	2h	NUM
eurjchem-1346	295	19	,	,	PUNCT
eurjchem-1346	295	20	ch2	ch2	PROPN
eurjchem-1346	295	21	)	)	PUNCT
eurjchem-1346	295	22	,	,	PUNCT
eurjchem-1346	295	23	7.22	7.22	NUM
eurjchem-1346	295	24	(	(	PUNCT
eurjchem-1346	295	25	d	d	PROPN
eurjchem-1346	295	26	,	,	PUNCT
eurjchem-1346	295	27	j	j	PROPN
eurjchem-1346	295	28	=	=	SYM
eurjchem-1346	295	29	6.2	6.2	NUM
eurjchem-1346	295	30	hz	hz	NOUN
eurjchem-1346	295	31	,	,	PUNCT
eurjchem-1346	295	32	1h	1h	NUM
eurjchem-1346	295	33	,	,	PUNCT
eurjchem-1346	295	34	h‐8ar	h‐8ar	NOUN
eurjchem-1346	295	35	)	)	PUNCT
eurjchem-1346	295	36	,	,	PUNCT
eurjchem-1346	295	37	7.46	7.46	NUM
eurjchem-1346	295	38	(	(	PUNCT
eurjchem-1346	295	39	t	t	PROPN
eurjchem-1346	295	40	,	,	PUNCT
eurjchem-1346	295	41	1h	1h	NUM
eurjchem-1346	295	42	,	,	PUNCT
eurjchem-1346	295	43	h‐7ar	h‐7ar	NOUN
eurjchem-1346	295	44	)	)	PUNCT
eurjchem-1346	295	45	,	,	PUNCT
eurjchem-1346	295	46	7.66‐8.01	7.66‐8.01	NUM
eurjchem-1346	295	47	(	(	PUNCT
eurjchem-1346	295	48	m	m	PROPN
eurjchem-1346	295	49	,	,	PUNCT
eurjchem-1346	295	50	4h	4h	NOUN
eurjchem-1346	295	51	,	,	PUNCT
eurjchem-1346	295	52	h‐3	h‐3	NOUN
eurjchem-1346	295	53	’	'	PUNCT
eurjchem-1346	295	54	,	,	PUNCT
eurjchem-1346	295	55	4	4	NUM
eurjchem-1346	295	56	’	'	PUNCT
eurjchem-1346	295	57	,	,	PUNCT
eurjchem-1346	295	58	5	5	NUM
eurjchem-1346	295	59	’	'	PUNCT
eurjchem-1346	295	60	,	,	PUNCT
eurjchem-1346	295	61	6	6	NUM
eurjchem-1346	295	62	’	'	PUNCT
eurjchem-1346	295	63	ar	ar	NOUN
eurjchem-1346	295	64	)	)	PUNCT
eurjchem-1346	295	65	,	,	PUNCT
eurjchem-1346	295	66	8.26	8.26	NUM
eurjchem-1346	295	67	(	(	PUNCT
eurjchem-1346	295	68	d	d	PROPN
eurjchem-1346	295	69	,	,	PUNCT
eurjchem-1346	295	70	j	j	PROPN
eurjchem-1346	295	71	=	=	SYM
eurjchem-1346	295	72	8.0	8.0	NUM
eurjchem-1346	295	73	hz	hz	NOUN
eurjchem-1346	295	74	,	,	PUNCT
eurjchem-1346	295	75	1h	1h	NUM
eurjchem-1346	295	76	,	,	PUNCT
eurjchem-1346	295	77	h‐6	h‐6	NOUN
eurjchem-1346	295	78	ar	ar	NOUN
eurjchem-1346	295	79	)	)	PUNCT
eurjchem-1346	295	80	,	,	PUNCT
eurjchem-1346	295	81	11.33	11.33	NUM
eurjchem-1346	295	82	(	(	PUNCT
eurjchem-1346	295	83	s	s	PROPN
eurjchem-1346	295	84	,	,	PUNCT
eurjchem-1346	295	85	1h	1h	NUM
eurjchem-1346	295	86	,	,	PUNCT
eurjchem-1346	295	87	nh	nh	PROPN
eurjchem-1346	295	88	,	,	PUNCT
eurjchem-1346	295	89	exchanged	exchange	VERB
eurjchem-1346	295	90	with	with	ADP
eurjchem-1346	295	91	d2o	d2o	NOUN
eurjchem-1346	295	92	)	)	PUNCT
eurjchem-1346	295	93	,	,	PUNCT
eurjchem-1346	295	94	11.55	11.55	NUM
eurjchem-1346	295	95	(	(	PUNCT
eurjchem-1346	295	96	s	s	PROPN
eurjchem-1346	295	97	,	,	PUNCT
eurjchem-1346	295	98	1h	1h	NUM
eurjchem-1346	295	99	,	,	PUNCT
eurjchem-1346	295	100	nh	nh	PROPN
eurjchem-1346	295	101	,	,	PUNCT
eurjchem-1346	295	102	exchanged	exchange	VERB
eurjchem-1346	295	103	with	with	ADP
eurjchem-1346	295	104	d2o	d2o	NOUN
eurjchem-1346	295	105	)	)	PUNCT
eurjchem-1346	295	106	.	.	PUNCT
eurjchem-1346	296	1	anal	anal	PROPN
eurjchem-1346	296	2	.	.	PUNCT
eurjchem-1346	296	3	calcd	calcd	NOUN
eurjchem-1346	296	4	.	.	PUNCT
eurjchem-1346	297	1	for	for	ADP
eurjchem-1346	297	2	c16h11n5o3	c16h11n5o3	PROPN
eurjchem-1346	297	3	:	:	PUNCT
eurjchem-1346	297	4	c	c	X
eurjchem-1346	297	5	,	,	PUNCT
eurjchem-1346	297	6	59.81	59.81	NUM
eurjchem-1346	297	7	;	;	PUNCT
eurjchem-1346	297	8	h	h	NOUN
eurjchem-1346	297	9	,	,	PUNCT
eurjchem-1346	297	10	3.45	3.45	NUM
eurjchem-1346	297	11	;	;	PUNCT
eurjchem-1346	297	12	n	n	CCONJ
eurjchem-1346	297	13	,	,	PUNCT
eurjchem-1346	297	14	21.80	21.80	NUM
eurjchem-1346	297	15	.	.	PUNCT
eurjchem-1346	298	1	found	find	VERB
eurjchem-1346	298	2	:	:	PUNCT
eurjchem-1346	299	1	c	c	X
eurjchem-1346	299	2	,	,	PUNCT
eurjchem-1346	299	3	59.97	59.97	NUM
eurjchem-1346	299	4	;	;	PUNCT
eurjchem-1346	299	5	h	h	NOUN
eurjchem-1346	299	6	,	,	PUNCT
eurjchem-1346	299	7	3.52	3.52	NUM
eurjchem-1346	299	8	;	;	PUNCT
eurjchem-1346	299	9	n	n	CCONJ
eurjchem-1346	299	10	,	,	PUNCT
eurjchem-1346	299	11	22.04	22.04	NUM
eurjchem-1346	299	12	%	%	NOUN
eurjchem-1346	299	13	.	.	PUNCT
eurjchem-1346	300	1	2.2	2.2	NUM
eurjchem-1346	300	2	.	.	PUNCT
eurjchem-1346	300	3	biological	biological	ADJ
eurjchem-1346	300	4	activity	activity	NOUN
eurjchem-1346	300	5	2.2.1	2.2.1	NUM
eurjchem-1346	300	6	.	.	PUNCT
eurjchem-1346	301	1	antitumor	antitumor	PROPN
eurjchem-1346	301	2	screening	screen	VERB
eurjchem-1346	301	3	the	the	DET
eurjchem-1346	301	4	cytotoxicity	cytotoxicity	NOUN
eurjchem-1346	301	5	of	of	ADP
eurjchem-1346	301	6	the	the	DET
eurjchem-1346	301	7	newly	newly	ADV
eurjchem-1346	301	8	synthesized	synthesize	VERB
eurjchem-1346	301	9	compounds	compound	NOUN
eurjchem-1346	301	10	was	be	AUX
eurjchem-1346	301	11	performed	perform	VERB
eurjchem-1346	301	12	against	against	ADP
eurjchem-1346	301	13	different	different	ADJ
eurjchem-1346	301	14	cancer	cancer	NOUN
eurjchem-1346	301	15	cell	cell	NOUN
eurjchem-1346	301	16	lines	line	NOUN
eurjchem-1346	301	17	,	,	PUNCT
eurjchem-1346	301	18	melanoma	melanoma	NOUN
eurjchem-1346	301	19	cell	cell	NOUN
eurjchem-1346	301	20	line	line	NOUN
eurjchem-1346	301	21	(	(	PUNCT
eurjchem-1346	301	22	loximvi	loximvi	PROPN
eurjchem-1346	301	23	)	)	PUNCT
eurjchem-1346	301	24	,	,	PUNCT
eurjchem-1346	301	25	ovarian	ovarian	ADJ
eurjchem-1346	301	26	cell	cell	NOUN
eurjchem-1346	301	27	line	line	NOUN
eurjchem-1346	301	28	(	(	PUNCT
eurjchem-1346	301	29	ovcar3	ovcar3	ADJ
eurjchem-1346	301	30	)	)	PUNCT
eurjchem-1346	301	31	,	,	PUNCT
eurjchem-1346	301	32	thyroid	thyroid	NOUN
eurjchem-1346	301	33	cell	cell	NOUN
eurjchem-1346	301	34	lines	line	NOUN
eurjchem-1346	301	35	(	(	PUNCT
eurjchem-1346	301	36	cal62	cal62	PROPN
eurjchem-1346	301	37	,	,	PUNCT
eurjchem-1346	301	38	ftc133	ftc133	PROPN
eurjchem-1346	301	39	,	,	PUNCT
eurjchem-1346	301	40	bcpap	bcpap	NOUN
eurjchem-1346	301	41	and	and	CCONJ
eurjchem-1346	301	42	ml1	ml1	NOUN
eurjchem-1346	301	43	)	)	PUNCT
eurjchem-1346	301	44	and	and	CCONJ
eurjchem-1346	301	45	colon	colon	NOUN
eurjchem-1346	301	46	cell	cell	NOUN
eurjchem-1346	301	47	lines	line	NOUN
eurjchem-1346	301	48	(	(	PUNCT
eurjchem-1346	301	49	ht29	ht29	PROPN
eurjchem-1346	301	50	and	and	CCONJ
eurjchem-1346	301	51	hct116	hct116	PROPN
eurjchem-1346	301	52	)	)	PUNCT
eurjchem-1346	301	53	,	,	PUNCT
eurjchem-1346	301	54	with	with	SCONJ
eurjchem-1346	301	55	the	the	DET
eurjchem-1346	301	56	mtt	mtt	NOUN
eurjchem-1346	301	57	assay	assay	VERB
eurjchem-1346	301	58	according	accord	VERB
eurjchem-1346	301	59	to	to	ADP
eurjchem-1346	301	60	the	the	DET
eurjchem-1346	301	61	mosmann	mosmann	PROPN
eurjchem-1346	301	62	’s	’s	PART
eurjchem-1346	301	63	method	method	NOUN
eurjchem-1346	301	64	[	[	X
eurjchem-1346	301	65	23	23	NUM
eurjchem-1346	301	66	]	]	PUNCT
eurjchem-1346	301	67	.	.	PUNCT
eurjchem-1346	302	1	the	the	DET
eurjchem-1346	302	2	cells	cell	NOUN
eurjchem-1346	302	3	used	use	VERB
eurjchem-1346	302	4	in	in	ADP
eurjchem-1346	302	5	cytotoxicity	cytotoxicity	NOUN
eurjchem-1346	302	6	assay	assay	NOUN
eurjchem-1346	302	7	were	be	AUX
eurjchem-1346	302	8	cultured	cultured	ADJ
eurjchem-1346	302	9	in	in	ADP
eurjchem-1346	302	10	rpmi	rpmi	NOUN
eurjchem-1346	302	11	1640	1640	NUM
eurjchem-1346	302	12	medium	medium	NOUN
eurjchem-1346	302	13	supplemented	supplement	VERB
eurjchem-1346	302	14	with	with	ADP
eurjchem-1346	302	15	10	10	NUM
eurjchem-1346	302	16	%	%	NOUN
eurjchem-1346	302	17	fetal	fetal	ADJ
eurjchem-1346	302	18	calf	calf	NOUN
eurjchem-1346	302	19	serum	serum	NOUN
eurjchem-1346	302	20	.	.	PUNCT
eurjchem-1346	303	1	cells	cell	NOUN
eurjchem-1346	303	2	suspended	suspend	VERB
eurjchem-1346	303	3	in	in	ADP
eurjchem-1346	303	4	the	the	DET
eurjchem-1346	303	5	medium	medium	NOUN
eurjchem-1346	303	6	(	(	PUNCT
eurjchem-1346	303	7	2×104	2×104	NUM
eurjchem-1346	303	8	/	/	SYM
eurjchem-1346	303	9	ml	ml	NOUN
eurjchem-1346	303	10	)	)	PUNCT
eurjchem-1346	303	11	were	be	AUX
eurjchem-1346	303	12	plated	plate	VERB
eurjchem-1346	303	13	in	in	ADP
eurjchem-1346	303	14	96‐well	96‐well	NUM
eurjchem-1346	303	15	culture	culture	NOUN
eurjchem-1346	303	16	plates	plate	NOUN
eurjchem-1346	303	17	and	and	CCONJ
eurjchem-1346	303	18	incubated	incubate	VERB
eurjchem-1346	303	19	at	at	ADP
eurjchem-1346	303	20	37	37	NUM
eurjchem-1346	303	21	°	°	ADP
eurjchem-1346	303	22	c	c	NOUN
eurjchem-1346	303	23	in	in	ADP
eurjchem-1346	303	24	a	a	DET
eurjchem-1346	303	25	5	5	NUM
eurjchem-1346	303	26	%	%	NOUN
eurjchem-1346	303	27	co2	co2	NOUN
eurjchem-1346	303	28	incubator	incubator	NOUN
eurjchem-1346	303	29	.	.	PUNCT
eurjchem-1346	304	1	after	after	ADP
eurjchem-1346	304	2	12	12	NUM
eurjchem-1346	304	3	h	h	NOUN
eurjchem-1346	304	4	,	,	PUNCT
eurjchem-1346	304	5	the	the	DET
eurjchem-1346	304	6	test	test	NOUN
eurjchem-1346	304	7	sample	sample	NOUN
eurjchem-1346	304	8	(	(	PUNCT
eurjchem-1346	304	9	2	2	NUM
eurjchem-1346	304	10	μl	μl	PRON
eurjchem-1346	304	11	)	)	PUNCT
eurjchem-1346	304	12	was	be	AUX
eurjchem-1346	304	13	added	add	VERB
eurjchem-1346	304	14	to	to	ADP
eurjchem-1346	304	15	the	the	DET
eurjchem-1346	304	16	cells	cell	NOUN
eurjchem-1346	304	17	(	(	PUNCT
eurjchem-1346	304	18	2×104	2×104	NUM
eurjchem-1346	304	19	)	)	PUNCT
eurjchem-1346	304	20	in	in	ADP
eurjchem-1346	304	21	96‐well	96‐well	NUM
eurjchem-1346	304	22	plates	plate	NOUN
eurjchem-1346	304	23	and	and	CCONJ
eurjchem-1346	304	24	cultured	cultured	ADJ
eurjchem-1346	304	25	at	at	ADP
eurjchem-1346	304	26	37	37	NUM
eurjchem-1346	304	27	°	°	ADP
eurjchem-1346	304	28	c	c	NOUN
eurjchem-1346	304	29	for	for	ADP
eurjchem-1346	304	30	3	3	NUM
eurjchem-1346	304	31	days	day	NOUN
eurjchem-1346	304	32	.	.	PUNCT
eurjchem-1346	305	1	the	the	DET
eurjchem-1346	305	2	cultured	cultured	ADJ
eurjchem-1346	305	3	cells	cell	NOUN
eurjchem-1346	305	4	were	be	AUX
eurjchem-1346	305	5	mixed	mix	VERB
eurjchem-1346	305	6	with	with	ADP
eurjchem-1346	305	7	20	20	NUM
eurjchem-1346	305	8	μl	μl	ADP
eurjchem-1346	305	9	of	of	ADP
eurjchem-1346	305	10	mtt	mtt	NOUN
eurjchem-1346	305	11	solution	solution	NOUN
eurjchem-1346	305	12	and	and	CCONJ
eurjchem-1346	305	13	incubated	incubate	VERB
eurjchem-1346	305	14	for	for	ADP
eurjchem-1346	305	15	4	4	NUM
eurjchem-1346	305	16	h	h	NOUN
eurjchem-1346	305	17	at	at	ADP
eurjchem-1346	305	18	37	37	NUM
eurjchem-1346	305	19	°	°	NOUN
eurjchem-1346	305	20	c	c	NOUN
eurjchem-1346	305	21	.	.	PUNCT
eurjchem-1346	306	1	the	the	DET
eurjchem-1346	306	2	supernatant	supernatant	NOUN
eurjchem-1346	306	3	was	be	AUX
eurjchem-1346	306	4	carefully	carefully	ADV
eurjchem-1346	306	5	removed	remove	VERB
eurjchem-1346	306	6	from	from	ADP
eurjchem-1346	306	7	each	each	DET
eurjchem-1346	306	8	well	well	NOUN
eurjchem-1346	306	9	and	and	CCONJ
eurjchem-1346	306	10	100	100	NUM
eurjchem-1346	306	11	μl	μl	ADP
eurjchem-1346	306	12	of	of	ADP
eurjchem-1346	306	13	dmso	dmso	NOUN
eurjchem-1346	306	14	were	be	AUX
eurjchem-1346	306	15	added	add	VERB
eurjchem-1346	306	16	to	to	ADP
eurjchem-1346	306	17	each	each	DET
eurjchem-1346	306	18	well	well	NOUN
eurjchem-1346	306	19	to	to	PART
eurjchem-1346	306	20	dissolve	dissolve	VERB
eurjchem-1346	306	21	the	the	DET
eurjchem-1346	306	22	formazan	formazan	ADJ
eurjchem-1346	306	23	crystals	crystal	NOUN
eurjchem-1346	306	24	which	which	PRON
eurjchem-1346	306	25	were	be	AUX
eurjchem-1346	306	26	formed	form	VERB
eurjchem-1346	306	27	by	by	ADP
eurjchem-1346	306	28	the	the	DET
eurjchem-1346	306	29	cellular	cellular	ADJ
eurjchem-1346	306	30	reduction	reduction	NOUN
eurjchem-1346	306	31	of	of	ADP
eurjchem-1346	306	32	mtt	mtt	NOUN
eurjchem-1346	306	33	.	.	PUNCT
eurjchem-1346	307	1	after	after	ADP
eurjchem-1346	307	2	mixing	mix	VERB
eurjchem-1346	307	3	with	with	ADP
eurjchem-1346	307	4	a	a	DET
eurjchem-1346	307	5	mechanical	mechanical	ADJ
eurjchem-1346	307	6	plate	plate	NOUN
eurjchem-1346	307	7	mixer	mixer	NOUN
eurjchem-1346	307	8	,	,	PUNCT
eurjchem-1346	307	9	the	the	DET
eurjchem-1346	307	10	absorbance	absorbance	NOUN
eurjchem-1346	307	11	of	of	ADP
eurjchem-1346	307	12	each	each	DET
eurjchem-1346	307	13	well	well	ADV
eurjchem-1346	307	14	was	be	AUX
eurjchem-1346	307	15	measured	measure	VERB
eurjchem-1346	307	16	by	by	ADP
eurjchem-1346	307	17	a	a	DET
eurjchem-1346	307	18	microplate	microplate	NOUN
eurjchem-1346	307	19	reader	reader	NOUN
eurjchem-1346	307	20	using	use	VERB
eurjchem-1346	307	21	a	a	DET
eurjchem-1346	307	22	test	test	NOUN
eurjchem-1346	307	23	wavelength	wavelength	NOUN
eurjchem-1346	307	24	of	of	ADP
eurjchem-1346	307	25	570	570	NUM
eurjchem-1346	307	26	nm	nm	NOUN
eurjchem-1346	307	27	[	[	X
eurjchem-1346	307	28	24	24	NUM
eurjchem-1346	307	29	]	]	PUNCT
eurjchem-1346	307	30	.	.	PUNCT
eurjchem-1346	308	1	the	the	DET
eurjchem-1346	308	2	results	result	NOUN
eurjchem-1346	308	3	were	be	AUX
eurjchem-1346	308	4	expressed	express	VERB
eurjchem-1346	308	5	as	as	ADP
eurjchem-1346	308	6	the	the	DET
eurjchem-1346	308	7	ic50	ic50	PROPN
eurjchem-1346	308	8	[	[	X
eurjchem-1346	308	9	23	23	NUM
eurjchem-1346	308	10	]	]	PUNCT
eurjchem-1346	308	11	,	,	PUNCT
eurjchem-1346	308	12	which	which	PRON
eurjchem-1346	308	13	inducing	induce	VERB
eurjchem-1346	308	14	a	a	DET
eurjchem-1346	308	15	50	50	NUM
eurjchem-1346	308	16	%	%	NOUN
eurjchem-1346	308	17	inhibition	inhibition	NOUN
eurjchem-1346	308	18	of	of	ADP
eurjchem-1346	308	19	cell	cell	NOUN
eurjchem-1346	308	20	growth	growth	NOUN
eurjchem-1346	308	21	of	of	ADP
eurjchem-1346	308	22	treated	treat	VERB
eurjchem-1346	308	23	cells	cell	NOUN
eurjchem-1346	308	24	when	when	SCONJ
eurjchem-1346	308	25	compared	compare	VERB
eurjchem-1346	308	26	to	to	ADP
eurjchem-1346	308	27	the	the	DET
eurjchem-1346	308	28	growth	growth	NOUN
eurjchem-1346	308	29	of	of	ADP
eurjchem-1346	308	30	control	control	NOUN
eurjchem-1346	308	31	cells	cell	NOUN
eurjchem-1346	308	32	.	.	PUNCT
eurjchem-1346	309	1	each	each	DET
eurjchem-1346	309	2	experiment	experiment	NOUN
eurjchem-1346	309	3	was	be	AUX
eurjchem-1346	309	4	performed	perform	VERB
eurjchem-1346	309	5	at	at	ADP
eurjchem-1346	309	6	least	least	ADV
eurjchem-1346	309	7	3	3	NUM
eurjchem-1346	309	8	times	time	NOUN
eurjchem-1346	309	9	.	.	PUNCT
eurjchem-1346	310	1	the	the	DET
eurjchem-1346	310	2	concentration	concentration	NOUN
eurjchem-1346	310	3	ranges	range	NOUN
eurjchem-1346	310	4	used	use	VERB
eurjchem-1346	310	5	were	be	AUX
eurjchem-1346	310	6	0.00001	0.00001	NUM
eurjchem-1346	310	7	,	,	PUNCT
eurjchem-1346	310	8	0.00005	0.00005	NUM
eurjchem-1346	310	9	,	,	PUNCT
eurjchem-1346	310	10	0.0001	0.0001	NUM
eurjchem-1346	310	11	,	,	PUNCT
eurjchem-1346	310	12	0.0005	0.0005	NUM
eurjchem-1346	310	13	,	,	PUNCT
eurjchem-1346	310	14	0.001	0.001	NUM
eurjchem-1346	310	15	,	,	PUNCT
eurjchem-1346	310	16	0.005	0.005	NUM
eurjchem-1346	310	17	,	,	PUNCT
eurjchem-1346	310	18	0.01	0.01	NUM
eurjchem-1346	310	19	,	,	PUNCT
eurjchem-1346	310	20	0.05	0.05	NUM
eurjchem-1346	310	21	,	,	PUNCT
eurjchem-1346	310	22	0.1	0.1	NUM
eurjchem-1346	310	23	,	,	PUNCT
eurjchem-1346	310	24	0.5	0.5	NUM
eurjchem-1346	310	25	,	,	PUNCT
eurjchem-1346	310	26	1	1	NUM
eurjchem-1346	310	27	,	,	PUNCT
eurjchem-1346	310	28	5	5	NUM
eurjchem-1346	310	29	and	and	CCONJ
eurjchem-1346	310	30	10	10	NUM
eurjchem-1346	310	31	μm	μm	NOUN
eurjchem-1346	310	32	.	.	PUNCT
eurjchem-1346	311	1	there	there	PRON
eurjchem-1346	311	2	was	be	VERB
eurjchem-1346	311	3	a	a	DET
eurjchem-1346	311	4	good	good	ADJ
eurjchem-1346	311	5	reproducibility	reproducibility	NOUN
eurjchem-1346	311	6	between	between	ADP
eurjchem-1346	311	7	replicate	replicate	VERB
eurjchem-1346	311	8	wells	well	NOUN
eurjchem-1346	311	9	with	with	ADP
eurjchem-1346	311	10	standard	standard	ADJ
eurjchem-1346	311	11	errors	error	NOUN
eurjchem-1346	311	12	below	below	ADP
eurjchem-1346	311	13	10	10	NUM
eurjchem-1346	311	14	%	%	NOUN
eurjchem-1346	311	15	.	.	PUNCT
eurjchem-1346	312	1	2.2.2	2.2.2	X
eurjchem-1346	312	2	.	.	PUNCT
eurjchem-1346	312	3	in	in	ADP
eurjchem-1346	312	4	vitro	vitro	X
eurjchem-1346	312	5	kinase	kinase	PROPN
eurjchem-1346	312	6	assay	assay	PROPN
eurjchem-1346	312	7	2.2.2.1	2.2.2.1	PROPN
eurjchem-1346	312	8	.	.	PUNCT
eurjchem-1346	312	9	protein	protein	NOUN
eurjchem-1346	312	10	expression	expression	NOUN
eurjchem-1346	312	11	and	and	CCONJ
eurjchem-1346	312	12	purification	purification	NOUN
eurjchem-1346	312	13	human	human	ADJ
eurjchem-1346	312	14	braf	braf	PROPN
eurjchem-1346	312	15	kinase	kinase	NOUN
eurjchem-1346	312	16	domain	domain	NOUN
eurjchem-1346	312	17	,	,	PUNCT
eurjchem-1346	312	18	braf‐kd	braf‐kd	PROPN
eurjchem-1346	312	19	(	(	PUNCT
eurjchem-1346	312	20	residues	residue	NOUN
eurjchem-1346	312	21	433‐726	433‐726	NUM
eurjchem-1346	312	22	)	)	PUNCT
eurjchem-1346	312	23	with	with	ADP
eurjchem-1346	312	24	an	an	DET
eurjchem-1346	312	25	n‐terminal	n‐terminal	PRON
eurjchem-1346	312	26	purification	purification	NOUN
eurjchem-1346	312	27	tag	tag	NOUN
eurjchem-1346	312	28	(	(	PUNCT
eurjchem-1346	312	29	mdrgsh6gs	mdrgsh6gs	NOUN
eurjchem-1346	312	30	)	)	PUNCT
eurjchem-1346	312	31	,	,	PUNCT
eurjchem-1346	312	32	and	and	CCONJ
eurjchem-1346	312	33	full‐	full‐	NUM
eurjchem-1346	312	34	length	length	PROPN
eurjchem-1346	312	35	mouse	mouse	PROPN
eurjchem-1346	312	36	p50cdc37	p50cdc37	NOUN
eurjchem-1346	312	37	were	be	AUX
eurjchem-1346	312	38	cloned	clone	VERB
eurjchem-1346	312	39	into	into	ADP
eurjchem-1346	312	40	a	a	DET
eurjchem-1346	312	41	pfastbac	pfastbac	NOUN
eurjchem-1346	312	42	dual	dual	ADJ
eurjchem-1346	312	43	vector	vector	NOUN
eurjchem-1346	312	44	.	.	PUNCT
eurjchem-1346	313	1	braf	braf	NOUN
eurjchem-1346	313	2	wild‐type	wild‐type	PUNCT
eurjchem-1346	313	3	and	and	CCONJ
eurjchem-1346	313	4	v600e	v600e	PROPN
eurjchem-1346	313	5	mutant	mutant	ADJ
eurjchem-1346	313	6	kinase	kinase	PROPN
eurjchem-1346	313	7	domains	domain	NOUN
eurjchem-1346	313	8	were	be	AUX
eurjchem-1346	313	9	expressed	express	VERB
eurjchem-1346	313	10	and	and	CCONJ
eurjchem-1346	313	11	purified	purified	ADJ
eurjchem-1346	313	12	.	.	PUNCT
eurjchem-1346	314	1	briefly	briefly	ADV
eurjchem-1346	314	2	,	,	PUNCT
eurjchem-1346	314	3	sf9	sf9	VERB
eurjchem-1346	314	4	cells	cell	NOUN
eurjchem-1346	314	5	infected	infect	VERB
eurjchem-1346	314	6	with	with	ADP
eurjchem-1346	314	7	the	the	DET
eurjchem-1346	314	8	braf	braf	PROPN
eurjchem-1346	314	9	kinase	kinase	PROPN
eurjchem-1346	314	10	domain	domain	PROPN
eurjchem-1346	314	11	harboring	harboring	NOUN
eurjchem-1346	314	12	baculo	baculo	PROPN
eurjchem-1346	314	13	virus	virus	NOUN
eurjchem-1346	314	14	were	be	AUX
eurjchem-1346	314	15	re‐	re‐	NOUN
eurjchem-1346	314	16	suspended	suspend	VERB
eurjchem-1346	314	17	in	in	ADP
eurjchem-1346	314	18	sonication	sonication	NOUN
eurjchem-1346	314	19	buffer	buffer	NOUN
eurjchem-1346	314	20	for	for	ADP
eurjchem-1346	314	21	sonication	sonication	NOUN
eurjchem-1346	314	22	,	,	PUNCT
eurjchem-1346	314	23	and	and	CCONJ
eurjchem-1346	314	24	the	the	DET
eurjchem-1346	314	25	lysate	lysate	NOUN
eurjchem-1346	314	26	was	be	AUX
eurjchem-1346	314	27	cleared	clear	VERB
eurjchem-1346	314	28	by	by	ADP
eurjchem-1346	314	29	high‐speed	high‐speed	PROPN
eurjchem-1346	314	30	centrifugation	centrifugation	NOUN
eurjchem-1346	314	31	.	.	PUNCT
eurjchem-1346	315	1	equilibrated	equilibrate	VERB
eurjchem-1346	315	2	talon	talon	PROPN
eurjchem-1346	315	3	resin	resin	PROPN
eurjchem-1346	315	4	was	be	AUX
eurjchem-1346	315	5	added	add	VERB
eurjchem-1346	315	6	into	into	ADP
eurjchem-1346	315	7	the	the	DET
eurjchem-1346	315	8	cleared	clear	VERB
eurjchem-1346	315	9	lysate	lysate	NOUN
eurjchem-1346	315	10	;	;	PUNCT
eurjchem-1346	315	11	the	the	DET
eurjchem-1346	315	12	resin	resin	NOUN
eurjchem-1346	315	13	was	be	AUX
eurjchem-1346	315	14	washed	wash	VERB
eurjchem-1346	315	15	with	with	ADP
eurjchem-1346	315	16	10	10	NUM
eurjchem-1346	315	17	column	column	NOUN
eurjchem-1346	315	18	volumes	volume	NOUN
eurjchem-1346	315	19	of	of	ADP
eurjchem-1346	315	20	wash	wash	NOUN
eurjchem-1346	315	21	buffer	buffer	NOUN
eurjchem-1346	315	22	(	(	PUNCT
eurjchem-1346	315	23	25	25	NUM
eurjchem-1346	315	24	mm	mm	NOUN
eurjchem-1346	315	25	tris	tris	NOUN
eurjchem-1346	315	26	(	(	PUNCT
eurjchem-1346	315	27	ph	ph	NOUN
eurjchem-1346	315	28	=	=	NOUN
eurjchem-1346	315	29	8.0	8.0	NUM
eurjchem-1346	315	30	)	)	PUNCT
eurjchem-1346	315	31	,	,	PUNCT
eurjchem-1346	315	32	250	250	NUM
eurjchem-1346	315	33	mm	mm	NUM
eurjchem-1346	315	34	nacl	nacl	NOUN
eurjchem-1346	315	35	,	,	PUNCT
eurjchem-1346	315	36	5	5	NUM
eurjchem-1346	315	37	mm	mm	NOUN
eurjchem-1346	315	38	imidazole	imidazole	NOUN
eurjchem-1346	315	39	,	,	PUNCT
eurjchem-1346	315	40	and	and	CCONJ
eurjchem-1346	315	41	10	10	NUM
eurjchem-1346	315	42	%	%	NOUN
eurjchem-1346	315	43	glycerol	glycerol	NOUN
eurjchem-1346	315	44	)	)	PUNCT
eurjchem-1346	315	45	and	and	CCONJ
eurjchem-1346	315	46	then	then	ADV
eurjchem-1346	315	47	eluted	elute	VERB
eurjchem-1346	315	48	with	with	ADP
eurjchem-1346	315	49	addition	addition	NOUN
eurjchem-1346	315	50	of	of	ADP
eurjchem-1346	315	51	buffer	buffer	NOUN
eurjchem-1346	315	52	(	(	PUNCT
eurjchem-1346	315	53	25	25	NUM
eurjchem-1346	315	54	mm	mm	NOUN
eurjchem-1346	315	55	tris	tris	NOUN
eurjchem-1346	315	56	(	(	PUNCT
eurjchem-1346	315	57	ph	ph	NOUN
eurjchem-1346	315	58	=	=	NOUN
eurjchem-1346	315	59	7.0	7.0	NUM
eurjchem-1346	315	60	)	)	PUNCT
eurjchem-1346	315	61	,	,	PUNCT
eurjchem-1346	315	62	250	250	NUM
eurjchem-1346	315	63	mm	mm	NUM
eurjchem-1346	315	64	nacl	nacl	NOUN
eurjchem-1346	315	65	,	,	PUNCT
eurjchem-1346	315	66	160	160	NUM
eurjchem-1346	315	67	mm	mm	NOUN
eurjchem-1346	315	68	imidazole	imidazole	NOUN
eurjchem-1346	315	69	,	,	PUNCT
eurjchem-1346	315	70	and	and	CCONJ
eurjchem-1346	315	71	10	10	NUM
eurjchem-1346	315	72	%	%	NOUN
eurjchem-1346	315	73	glycerol	glycerol	NOUN
eurjchem-1346	315	74	)	)	PUNCT
eurjchem-1346	315	75	.	.	PUNCT
eurjchem-1346	316	1	the	the	DET
eurjchem-1346	316	2	eluant	eluant	NOUN
eurjchem-1346	316	3	from	from	ADP
eurjchem-1346	316	4	the	the	DET
eurjchem-1346	316	5	talon	talon	PROPN
eurjchem-1346	316	6	resin	resin	NOUN
eurjchem-1346	316	7	was	be	AUX
eurjchem-1346	316	8	diluted	dilute	VERB
eurjchem-1346	316	9	3‐fold	3‐fold	NUM
eurjchem-1346	316	10	and	and	CCONJ
eurjchem-1346	316	11	loaded	load	VERB
eurjchem-1346	316	12	on	on	ADP
eurjchem-1346	316	13	a	a	DET
eurjchem-1346	316	14	sp	sp	NOUN
eurjchem-1346	316	15	resin	resin	NOUN
eurjchem-1346	316	16	column	column	NOUN
eurjchem-1346	316	17	.	.	PUNCT
eurjchem-1346	317	1	sp	sp	ADP
eurjchem-1346	317	2	resin	resin	NOUN
eurjchem-1346	317	3	was	be	AUX
eurjchem-1346	317	4	extensively	extensively	ADV
eurjchem-1346	317	5	washed	wash	VERB
eurjchem-1346	317	6	(	(	PUNCT
eurjchem-1346	317	7	25	25	NUM
eurjchem-1346	317	8	mm	mm	NOUN
eurjchem-1346	317	9	tris	tris	NOUN
eurjchem-1346	317	10	(	(	PUNCT
eurjchem-1346	317	11	ph	ph	NOUN
eurjchem-1346	317	12	=	=	NOUN
eurjchem-1346	317	13	8.0	8.0	NUM
eurjchem-1346	317	14	)	)	PUNCT
eurjchem-1346	317	15	,	,	PUNCT
eurjchem-1346	317	16	50	50	NUM
eurjchem-1346	317	17	mm	mm	NOUN
eurjchem-1346	317	18	nacl	nacl	NOUN
eurjchem-1346	317	19	,	,	PUNCT
eurjchem-1346	317	20	1	1	NUM
eurjchem-1346	317	21	mm	mm	NOUN
eurjchem-1346	317	22	dithiothreitol	dithiothreitol	NOUN
eurjchem-1346	317	23	,	,	PUNCT
eurjchem-1346	317	24	and	and	CCONJ
eurjchem-1346	317	25	10	10	NUM
eurjchem-1346	317	26	%	%	NOUN
eurjchem-1346	317	27	glycerol	glycerol	NOUN
eurjchem-1346	317	28	)	)	PUNCT
eurjchem-1346	317	29	and	and	CCONJ
eurjchem-1346	317	30	eluted	elute	VERB
eurjchem-1346	317	31	with	with	ADP
eurjchem-1346	317	32	high‐salt	high‐salt	NOUN
eurjchem-1346	317	33	buffer	buffer	NOUN
eurjchem-1346	317	34	(	(	PUNCT
eurjchem-1346	317	35	25	25	NUM
eurjchem-1346	317	36	mm	mm	NOUN
eurjchem-1346	317	37	tris	tris	NOUN
eurjchem-1346	317	38	(	(	PUNCT
eurjchem-1346	317	39	ph	ph	NOUN
eurjchem-1346	317	40	=	=	NOUN
eurjchem-1346	317	41	8.0	8.0	NUM
eurjchem-1346	317	42	)	)	PUNCT
eurjchem-1346	317	43	,	,	PUNCT
eurjchem-1346	317	44	500	500	NUM
eurjchem-1346	317	45	mm	mm	NOUN
eurjchem-1346	317	46	nacl	nacl	NOUN
eurjchem-1346	317	47	,	,	PUNCT
eurjchem-1346	317	48	1	1	NUM
eurjchem-1346	317	49	mm	mm	NOUN
eurjchem-1346	317	50	dithiothreitol	dithiothreitol	NOUN
eurjchem-1346	317	51	,	,	PUNCT
eurjchem-1346	317	52	1	1	NUM
eurjchem-1346	317	53	mm	mm	NUM
eurjchem-1346	317	54	edta	edta	NOUN
eurjchem-1346	317	55	,	,	PUNCT
eurjchem-1346	317	56	and	and	CCONJ
eurjchem-1346	317	57	10	10	NUM
eurjchem-1346	317	58	%	%	NOUN
eurjchem-1346	317	59	glycerol	glycerol	NOUN
eurjchem-1346	317	60	)	)	PUNCT
eurjchem-1346	317	61	.	.	PUNCT
eurjchem-1346	318	1	recombinantly	recombinantly	ADV
eurjchem-1346	318	2	expressed	express	VERB
eurjchem-1346	318	3	λ	λ	PROPN
eurjchem-1346	318	4	phosphatase	phosphatase	NOUN
eurjchem-1346	318	5	was	be	AUX
eurjchem-1346	318	6	then	then	ADV
eurjchem-1346	318	7	added	add	VERB
eurjchem-1346	318	8	to	to	ADP
eurjchem-1346	318	9	the	the	DET
eurjchem-1346	318	10	sp	sp	NOUN
eurjchem-1346	318	11	eluant	eluant	NOUN
eurjchem-1346	318	12	and	and	CCONJ
eurjchem-1346	318	13	incubated	incubate	VERB
eurjchem-1346	318	14	for	for	ADP
eurjchem-1346	318	15	2	2	NUM
eurjchem-1346	318	16	h	h	NOUN
eurjchem-1346	318	17	at	at	ADP
eurjchem-1346	318	18	room	room	NOUN
eurjchem-1346	318	19	temperature	temperature	NOUN
eurjchem-1346	318	20	followed	follow	VERB
eurjchem-1346	318	21	by	by	ADP
eurjchem-1346	318	22	7‐fold	7‐fold	NUM
eurjchem-1346	318	23	dilution	dilution	NOUN
eurjchem-1346	318	24	in	in	ADP
eurjchem-1346	318	25	buffer	buffer	NOUN
eurjchem-1346	318	26	(	(	PUNCT
eurjchem-1346	318	27	25	25	NUM
eurjchem-1346	318	28	mm	mm	NOUN
eurjchem-1346	318	29	tris	tris	NOUN
eurjchem-1346	318	30	(	(	PUNCT
eurjchem-1346	318	31	ph	ph	NOUN
eurjchem-1346	318	32	=	=	NOUN
eurjchem-1346	318	33	8.0	8.0	NUM
eurjchem-1346	318	34	)	)	PUNCT
eurjchem-1346	318	35	,	,	PUNCT
eurjchem-1346	318	36	1	1	NUM
eurjchem-1346	318	37	mm	mm	NOUN
eurjchem-1346	318	38	dithiothreitol	dithiothreitol	NOUN
eurjchem-1346	318	39	,	,	PUNCT
eurjchem-1346	318	40	1	1	NUM
eurjchem-1346	318	41	mm	mm	NUM
eurjchem-1346	318	42	edta	edta	NOUN
eurjchem-1346	318	43	,	,	PUNCT
eurjchem-1346	318	44	and	and	CCONJ
eurjchem-1346	318	45	10	10	NUM
eurjchem-1346	318	46	%	%	NOUN
eurjchem-1346	318	47	24	24	NUM
eurjchem-1346	318	48	amin	amin	NOUN
eurjchem-1346	318	49	et	et	PROPN
eurjchem-1346	318	50	al	al	PROPN
eurjchem-1346	318	51	.	.	PUNCT
eurjchem-1346	318	52	/	/	SYM
eurjchem-1346	318	53	european	european	PROPN
eurjchem-1346	318	54	journal	journal	PROPN
eurjchem-1346	318	55	of	of	ADP
eurjchem-1346	318	56	chemistry	chemistry	NOUN
eurjchem-1346	318	57	7	7	NUM
eurjchem-1346	318	58	(	(	PUNCT
eurjchem-1346	318	59	1	1	NUM
eurjchem-1346	318	60	)	)	PUNCT
eurjchem-1346	318	61	(	(	PUNCT
eurjchem-1346	318	62	2016	2016	NUM
eurjchem-1346	318	63	)	)	PUNCT
eurjchem-1346	318	64	19‐29	19‐29	NUM
eurjchem-1346	318	65	glycerol	glycerol	NOUN
eurjchem-1346	318	66	)	)	PUNCT
eurjchem-1346	318	67	.	.	PUNCT
eurjchem-1346	319	1	this	this	DET
eurjchem-1346	319	2	dilution	dilution	NOUN
eurjchem-1346	319	3	was	be	AUX
eurjchem-1346	319	4	reloaded	reload	VERB
eurjchem-1346	319	5	on	on	ADP
eurjchem-1346	319	6	an	an	DET
eurjchem-1346	319	7	sp	sp	NOUN
eurjchem-1346	319	8	resin	resin	NOUN
eurjchem-1346	319	9	column	column	NOUN
eurjchem-1346	319	10	to	to	PART
eurjchem-1346	319	11	remove	remove	VERB
eurjchem-1346	319	12	the	the	DET
eurjchem-1346	319	13	λ	λ	NOUN
eurjchem-1346	319	14	phosphatase	phosphatase	NOUN
eurjchem-1346	319	15	.	.	PUNCT
eurjchem-1346	320	1	the	the	DET
eurjchem-1346	320	2	final	final	ADJ
eurjchem-1346	320	3	sp	sp	ADP
eurjchem-1346	320	4	eluant	eluant	NOUN
eurjchem-1346	320	5	was	be	AUX
eurjchem-1346	320	6	concentrated	concentrate	VERB
eurjchem-1346	320	7	and	and	CCONJ
eurjchem-1346	320	8	loaded	load	VERB
eurjchem-1346	320	9	onto	onto	ADP
eurjchem-1346	320	10	a	a	DET
eurjchem-1346	320	11	superdex	superdex	NOUN
eurjchem-1346	320	12	200	200	NUM
eurjchem-1346	320	13	gel	gel	NOUN
eurjchem-1346	320	14	filtration	filtration	NOUN
eurjchem-1346	320	15	column	column	NOUN
eurjchem-1346	320	16	equilibrated	equilibrate	VERB
eurjchem-1346	320	17	in	in	ADP
eurjchem-1346	320	18	buffer	buffer	NOUN
eurjchem-1346	320	19	(	(	PUNCT
eurjchem-1346	320	20	25	25	NUM
eurjchem-1346	320	21	mm	mm	NOUN
eurjchem-1346	320	22	tris	tris	NOUN
eurjchem-1346	320	23	(	(	PUNCT
eurjchem-1346	320	24	ph	ph	NOUN
eurjchem-1346	320	25	=	=	NOUN
eurjchem-1346	320	26	8.0	8.0	NUM
eurjchem-1346	320	27	)	)	PUNCT
eurjchem-1346	320	28	,	,	PUNCT
eurjchem-1346	320	29	300	300	NUM
eurjchem-1346	320	30	mm	mm	NOUN
eurjchem-1346	320	31	nacl	nacl	NOUN
eurjchem-1346	320	32	,	,	PUNCT
eurjchem-1346	320	33	1	1	NUM
eurjchem-1346	320	34	mm	mm	NOUN
eurjchem-1346	320	35	dithiothreitol	dithiothreitol	NOUN
eurjchem-1346	320	36	,	,	PUNCT
eurjchem-1346	320	37	1	1	NUM
eurjchem-1346	320	38	mm	mm	NUM
eurjchem-1346	320	39	edta	edta	NOUN
eurjchem-1346	320	40	,	,	PUNCT
eurjchem-1346	320	41	and	and	CCONJ
eurjchem-1346	320	42	5	5	NUM
eurjchem-1346	320	43	%	%	NOUN
eurjchem-1346	320	44	glycerol	glycerol	NOUN
eurjchem-1346	320	45	)	)	PUNCT
eurjchem-1346	320	46	.	.	PUNCT
eurjchem-1346	321	1	gel	gel	NOUN
eurjchem-1346	321	2	filtration	filtration	NOUN
eurjchem-1346	321	3	fractions	fraction	NOUN
eurjchem-1346	321	4	were	be	AUX
eurjchem-1346	321	5	concentrated	concentrate	VERB
eurjchem-1346	321	6	with	with	ADP
eurjchem-1346	321	7	a	a	DET
eurjchem-1346	321	8	final	final	ADJ
eurjchem-1346	321	9	glycerol	glycerol	NOUN
eurjchem-1346	321	10	concentration	concentration	NOUN
eurjchem-1346	321	11	of	of	ADP
eurjchem-1346	321	12	15	15	NUM
eurjchem-1346	321	13	%	%	NOUN
eurjchem-1346	321	14	to	to	ADP
eurjchem-1346	321	15	a	a	DET
eurjchem-1346	321	16	protein	protein	NOUN
eurjchem-1346	321	17	concentration	concentration	NOUN
eurjchem-1346	321	18	of	of	ADP
eurjchem-1346	321	19	1.5	1.5	NUM
eurjchem-1346	321	20	mg	mg	NUM
eurjchem-1346	321	21	/	/	SYM
eurjchem-1346	321	22	ml	ml	NOUN
eurjchem-1346	321	23	.	.	PUNCT
eurjchem-1346	322	1	braf‐kd	braf‐kd	PROPN
eurjchem-1346	322	2	protein	protein	NOUN
eurjchem-1346	322	3	was	be	AUX
eurjchem-1346	322	4	immediately	immediately	ADV
eurjchem-1346	322	5	used	use	VERB
eurjchem-1346	322	6	for	for	ADP
eurjchem-1346	322	7	crystallization	crystallization	NOUN
eurjchem-1346	322	8	.	.	PUNCT
eurjchem-1346	323	1	gst‐mek‐his	gst‐mek‐his	DET
eurjchem-1346	323	2	protein	protein	NOUN
eurjchem-1346	323	3	was	be	AUX
eurjchem-1346	323	4	overexpressed	overexpresse	VERB
eurjchem-1346	323	5	at	at	ADP
eurjchem-1346	323	6	37	37	NUM
eurjchem-1346	323	7	°	°	NOUN
eurjchem-1346	323	8	c	c	NOUN
eurjchem-1346	323	9	in	in	ADP
eurjchem-1346	323	10	escherichia	escherichia	NOUN
eurjchem-1346	323	11	coli	coli	NOUN
eurjchem-1346	323	12	bl21	bl21	PROPN
eurjchem-1346	323	13	(	(	PUNCT
eurjchem-1346	323	14	gold	gold	NOUN
eurjchem-1346	323	15	)	)	PUNCT
eurjchem-1346	323	16	cells	cell	NOUN
eurjchem-1346	323	17	(	(	PUNCT
eurjchem-1346	323	18	invitrogen	invitrogen	PROPN
eurjchem-1346	323	19	)	)	PUNCT
eurjchem-1346	323	20	in	in	ADP
eurjchem-1346	323	21	lb	lb	DET
eurjchem-1346	323	22	medium	medium	NOUN
eurjchem-1346	323	23	until	until	SCONJ
eurjchem-1346	323	24	the	the	DET
eurjchem-1346	323	25	od	od	PROPN
eurjchem-1346	323	26	value	value	NOUN
eurjchem-1346	323	27	reached	reach	VERB
eurjchem-1346	323	28	0.4‐0.6	0.4‐0.6	NOUN
eurjchem-1346	323	29	.	.	PUNCT
eurjchem-1346	324	1	isopropyl	isopropyl	PROPN
eurjchem-1346	324	2	1‐thio‐β‐d‐	1‐thio‐β‐d‐	NUM
eurjchem-1346	324	3	galactopyrano‐side	galactopyrano‐side	NOUN
eurjchem-1346	324	4	(	(	PUNCT
eurjchem-1346	324	5	iptg	iptg	PROPN
eurjchem-1346	324	6	,	,	PUNCT
eurjchem-1346	324	7	0.5	0.5	NUM
eurjchem-1346	324	8	mm	mm	NOUN
eurjchem-1346	324	9	)	)	PUNCT
eurjchem-1346	324	10	was	be	AUX
eurjchem-1346	324	11	then	then	ADV
eurjchem-1346	324	12	added	add	VERB
eurjchem-1346	324	13	to	to	ADP
eurjchem-1346	324	14	the	the	DET
eurjchem-1346	324	15	culture	culture	NOUN
eurjchem-1346	324	16	,	,	PUNCT
eurjchem-1346	324	17	which	which	PRON
eurjchem-1346	324	18	was	be	AUX
eurjchem-1346	324	19	grown	grow	VERB
eurjchem-1346	324	20	at	at	ADP
eurjchem-1346	324	21	15	15	NUM
eurjchem-1346	324	22	°	°	ADP
eurjchem-1346	324	23	c	c	NOUN
eurjchem-1346	324	24	for	for	ADP
eurjchem-1346	324	25	an	an	DET
eurjchem-1346	324	26	additional	additional	ADJ
eurjchem-1346	324	27	16	16	NUM
eurjchem-1346	324	28	h.	h.	NOUN
eurjchem-1346	324	29	the	the	DET
eurjchem-1346	324	30	cell	cell	NOUN
eurjchem-1346	324	31	pellet	pellet	NOUN
eurjchem-1346	324	32	was	be	AUX
eurjchem-1346	324	33	re‐suspended	re‐suspende	VERB
eurjchem-1346	324	34	and	and	CCONJ
eurjchem-1346	324	35	sonicated	sonicate	VERB
eurjchem-1346	324	36	in	in	ADP
eurjchem-1346	324	37	sonication	sonication	NOUN
eurjchem-1346	324	38	buffer	buffer	NOUN
eurjchem-1346	324	39	(	(	PUNCT
eurjchem-1346	324	40	20	20	NUM
eurjchem-1346	324	41	mm	mm	NOUN
eurjchem-1346	324	42	hepes	hepe	NOUN
eurjchem-1346	324	43	(	(	PUNCT
eurjchem-1346	324	44	4‐(2‐hydroxyethyl)‐1‐piperazineethane	4‐(2‐hydroxyethyl)‐1‐piperazineethane	NOUN
eurjchem-1346	324	45	sulfonic	sulfonic	ADJ
eurjchem-1346	324	46	acid	acid	NOUN
eurjchem-1346	324	47	)	)	PUNCT
eurjchem-1346	324	48	)	)	PUNCT
eurjchem-1346	324	49	(	(	PUNCT
eurjchem-1346	324	50	ph	ph	NOUN
eurjchem-1346	324	51	=	=	NOUN
eurjchem-1346	324	52	7.5	7.5	NUM
eurjchem-1346	324	53	)	)	PUNCT
eurjchem-1346	324	54	,	,	PUNCT
eurjchem-1346	324	55	500	500	NUM
eurjchem-1346	324	56	mm	mm	NOUN
eurjchem-1346	324	57	nacl	nacl	NOUN
eurjchem-1346	324	58	,	,	PUNCT
eurjchem-1346	324	59	10	10	NUM
eurjchem-1346	324	60	mm	mm	NOUN
eurjchem-1346	324	61	2‐mercapto	2‐mercapto	NUM
eurjchem-1346	324	62	ethanol	ethanol	NOUN
eurjchem-1346	324	63	(	(	PUNCT
eurjchem-1346	324	64	bme	bme	NOUN
eurjchem-1346	324	65	)	)	PUNCT
eurjchem-1346	324	66	,	,	PUNCT
eurjchem-1346	324	67	10	10	NUM
eurjchem-1346	324	68	mm	mm	NOUN
eurjchem-1346	324	69	imidazole	imidazole	NOUN
eurjchem-1346	324	70	,	,	PUNCT
eurjchem-1346	324	71	0.1	0.1	NUM
eurjchem-1346	324	72	mg	mg	NUM
eurjchem-1346	324	73	/	/	SYM
eurjchem-1346	324	74	ml	ml	NOUN
eurjchem-1346	324	75	phenylmethane	phenylmethane	ADJ
eurjchem-1346	324	76	sulfonyl	sulfonyl	NOUN
eurjchem-1346	324	77	fluoride	fluoride	NOUN
eurjchem-1346	324	78	(	(	PUNCT
eurjchem-1346	324	79	pmsf	pmsf	NOUN
eurjchem-1346	324	80	)	)	PUNCT
eurjchem-1346	324	81	,	,	PUNCT
eurjchem-1346	324	82	and	and	CCONJ
eurjchem-1346	324	83	5	5	NUM
eurjchem-1346	324	84	%	%	NOUN
eurjchem-1346	324	85	glycerol	glycerol	NOUN
eurjchem-1346	324	86	)	)	PUNCT
eurjchem-1346	324	87	.	.	PUNCT
eurjchem-1346	325	1	the	the	DET
eurjchem-1346	325	2	lysate	lysate	NOUN
eurjchem-1346	325	3	was	be	AUX
eurjchem-1346	325	4	cleared	clear	VERB
eurjchem-1346	325	5	by	by	ADP
eurjchem-1346	325	6	high	high	ADJ
eurjchem-1346	325	7	speed	speed	NOUN
eurjchem-1346	325	8	centrifugation	centrifugation	NOUN
eurjchem-1346	325	9	before	before	SCONJ
eurjchem-1346	325	10	it	it	PRON
eurjchem-1346	325	11	was	be	AUX
eurjchem-1346	325	12	loaded	load	VERB
eurjchem-1346	325	13	onto	onto	ADP
eurjchem-1346	325	14	a	a	DET
eurjchem-1346	325	15	ni‐nta	ni‐nta	ADJ
eurjchem-1346	325	16	resin	resin	NOUN
eurjchem-1346	325	17	column	column	NOUN
eurjchem-1346	325	18	pre‐equilibrated	pre‐equilibrate	VERB
eurjchem-1346	325	19	in	in	ADP
eurjchem-1346	325	20	sonication	sonication	NOUN
eurjchem-1346	325	21	buffer	buffer	NOUN
eurjchem-1346	325	22	.	.	PUNCT
eurjchem-1346	326	1	the	the	DET
eurjchem-1346	326	2	protein‐bound	protein‐bound	ADJ
eurjchem-1346	326	3	ni‐nta	ni‐nta	NOUN
eurjchem-1346	326	4	resin	resin	NOUN
eurjchem-1346	326	5	was	be	AUX
eurjchem-1346	326	6	then	then	ADV
eurjchem-1346	326	7	extensively	extensively	ADV
eurjchem-1346	326	8	washed	wash	VERB
eurjchem-1346	326	9	with	with	ADP
eurjchem-1346	326	10	20	20	NUM
eurjchem-1346	326	11	column	column	NOUN
eurjchem-1346	326	12	volumes	volume	NOUN
eurjchem-1346	326	13	of	of	ADP
eurjchem-1346	326	14	wash	wash	NOUN
eurjchem-1346	326	15	buffer	buffer	NOUN
eurjchem-1346	326	16	,	,	PUNCT
eurjchem-1346	326	17	and	and	CCONJ
eurjchem-1346	326	18	the	the	DET
eurjchem-1346	326	19	gst‐mek‐his	gst‐mek‐his	PRON
eurjchem-1346	326	20	protein	protein	NOUN
eurjchem-1346	326	21	was	be	AUX
eurjchem-1346	326	22	eluted	elute	VERB
eurjchem-1346	326	23	with	with	ADP
eurjchem-1346	326	24	an	an	DET
eurjchem-1346	326	25	imidazole	imidazole	NOUN
eurjchem-1346	326	26	gradient	gradient	NOUN
eurjchem-1346	326	27	from	from	ADP
eurjchem-1346	326	28	10	10	NUM
eurjchem-1346	326	29	to	to	PART
eurjchem-1346	326	30	150	150	NUM
eurjchem-1346	326	31	mm	mm	NOUN
eurjchem-1346	326	32	in	in	ADP
eurjchem-1346	326	33	wash	wash	NOUN
eurjchem-1346	326	34	buffer	buffer	NOUN
eurjchem-1346	326	35	.	.	PUNCT
eurjchem-1346	327	1	fractions	fraction	NOUN
eurjchem-1346	327	2	corresponding	correspond	VERB
eurjchem-1346	327	3	to	to	ADP
eurjchem-1346	327	4	gst‐mek‐his	gst‐mek‐his	PROPN
eurjchem-1346	327	5	were	be	AUX
eurjchem-1346	327	6	pooled	pool	VERB
eurjchem-1346	327	7	and	and	CCONJ
eurjchem-1346	327	8	applied	apply	VERB
eurjchem-1346	327	9	to	to	ADP
eurjchem-1346	327	10	a	a	DET
eurjchem-1346	327	11	superdex	superdex	NOUN
eurjchem-1346	327	12	200	200	NUM
eurjchem-1346	327	13	column	column	NOUN
eurjchem-1346	327	14	equilibra‐	equilibra‐	PROPN
eurjchem-1346	327	15	ted	te	VERB
eurjchem-1346	327	16	in	in	ADP
eurjchem-1346	327	17	buffer	buffer	NOUN
eurjchem-1346	327	18	(	(	PUNCT
eurjchem-1346	327	19	20	20	NUM
eurjchem-1346	327	20	mm	mm	NOUN
eurjchem-1346	327	21	hepes	hepe	NOUN
eurjchem-1346	327	22	(	(	PUNCT
eurjchem-1346	327	23	ph	ph	NOUN
eurjchem-1346	327	24	=	=	NOUN
eurjchem-1346	327	25	7.5	7.5	NUM
eurjchem-1346	327	26	)	)	PUNCT
eurjchem-1346	327	27	,	,	PUNCT
eurjchem-1346	327	28	150	150	NUM
eurjchem-1346	327	29	mm	mm	NOUN
eurjchem-1346	327	30	nacl	nacl	NOUN
eurjchem-1346	327	31	,	,	PUNCT
eurjchem-1346	327	32	10	10	NUM
eurjchem-1346	327	33	mm	mm	NOUN
eurjchem-1346	327	34	bme	bme	NOUN
eurjchem-1346	327	35	,	,	PUNCT
eurjchem-1346	327	36	and	and	CCONJ
eurjchem-1346	327	37	5	5	NUM
eurjchem-1346	327	38	%	%	NOUN
eurjchem-1346	327	39	glycerol	glycerol	NOUN
eurjchem-1346	327	40	)	)	PUNCT
eurjchem-1346	327	41	.	.	PUNCT
eurjchem-1346	328	1	gel	gel	NOUN
eurjchem-1346	328	2	filtration	filtration	NOUN
eurjchem-1346	328	3	fractions	fraction	NOUN
eurjchem-1346	328	4	were	be	AUX
eurjchem-1346	328	5	pooled	pool	VERB
eurjchem-1346	328	6	and	and	CCONJ
eurjchem-1346	328	7	concentrated	concentrate	VERB
eurjchem-1346	328	8	to	to	ADP
eurjchem-1346	328	9	10	10	NUM
eurjchem-1346	328	10	mg	mg	NOUN
eurjchem-1346	328	11	/	/	SYM
eurjchem-1346	328	12	ml	ml	NOUN
eurjchem-1346	328	13	before	before	ADP
eurjchem-1346	328	14	being	be	AUX
eurjchem-1346	328	15	flash‐frozen	flash‐frozen	VERB
eurjchem-1346	328	16	in	in	ADP
eurjchem-1346	328	17	liquid	liquid	ADJ
eurjchem-1346	328	18	nitrogen	nitrogen	NOUN
eurjchem-1346	328	19	and	and	CCONJ
eurjchem-1346	328	20	stored	store	VERB
eurjchem-1346	328	21	at	at	ADP
eurjchem-1346	328	22	‐80	‐80	NOUN
eurjchem-1346	328	23	°	°	ADP
eurjchem-1346	328	24	c	c	NOUN
eurjchem-1346	328	25	until	until	ADP
eurjchem-1346	328	26	use	use	NOUN
eurjchem-1346	328	27	[	[	X
eurjchem-1346	328	28	25	25	NUM
eurjchem-1346	328	29	]	]	PUNCT
eurjchem-1346	328	30	.	.	PUNCT
eurjchem-1346	329	1	2.2.2.2	2.2.2.2	NUM
eurjchem-1346	329	2	.	.	NOUN
eurjchem-1346	329	3	in	in	ADP
eurjchem-1346	329	4	vitro	vitro	X
eurjchem-1346	329	5	elisa‐based	elisa‐base	VERB
eurjchem-1346	329	6	kinase	kinase	PROPN
eurjchem-1346	329	7	assay	assay	PROPN
eurjchem-1346	329	8	recombinantly	recombinantly	ADV
eurjchem-1346	329	9	expressed	express	VERB
eurjchem-1346	329	10	gst	gst	PROPN
eurjchem-1346	329	11	mek‐his	mek‐his	NOUN
eurjchem-1346	329	12	,	,	PUNCT
eurjchem-1346	329	13	diluted	dilute	VERB
eurjchem-1346	329	14	in	in	ADP
eurjchem-1346	329	15	ttbs	ttbs	NOUN
eurjchem-1346	329	16	buffer	buffer	NOUN
eurjchem-1346	329	17	(	(	PUNCT
eurjchem-1346	329	18	20	20	NUM
eurjchem-1346	329	19	mm	mm	NOUN
eurjchem-1346	329	20	tris	tris	NOUN
eurjchem-1346	329	21	(	(	PUNCT
eurjchem-1346	329	22	ph	ph	NOUN
eurjchem-1346	329	23	=	=	NOUN
eurjchem-1346	329	24	7.5	7.5	NUM
eurjchem-1346	329	25	)	)	PUNCT
eurjchem-1346	329	26	,	,	PUNCT
eurjchem-1346	329	27	150	150	NUM
eurjchem-1346	329	28	mm	mm	NOUN
eurjchem-1346	329	29	nacl	nacl	NOUN
eurjchem-1346	329	30	,	,	PUNCT
eurjchem-1346	329	31	and	and	CCONJ
eurjchem-1346	329	32	0.05	0.05	NUM
eurjchem-1346	329	33	%	%	NOUN
eurjchem-1346	329	34	tween	tween	NOUN
eurjchem-1346	329	35	20	20	NUM
eurjchem-1346	329	36	)	)	PUNCT
eurjchem-1346	329	37	to	to	ADP
eurjchem-1346	329	38	50	50	NUM
eurjchem-1346	329	39	μg	μg	NOUN
eurjchem-1346	329	40	/	/	SYM
eurjchem-1346	329	41	ml	ml	NOUN
eurjchem-1346	329	42	in	in	ADP
eurjchem-1346	329	43	a	a	DET
eurjchem-1346	329	44	volume	volume	NOUN
eurjchem-1346	329	45	of	of	ADP
eurjchem-1346	329	46	100	100	NUM
eurjchem-1346	329	47	μl	μl	ADP
eurjchem-1346	329	48	,	,	PUNCT
eurjchem-1346	329	49	was	be	AUX
eurjchem-1346	329	50	bound	bind	VERB
eurjchem-1346	329	51	to	to	ADP
eurjchem-1346	329	52	the	the	DET
eurjchem-1346	329	53	wells	well	NOUN
eurjchem-1346	329	54	of	of	ADP
eurjchem-1346	329	55	a	a	DET
eurjchem-1346	329	56	96‐well	96‐well	NUM
eurjchem-1346	329	57	glutathione‐coated	glutathione‐coate	VERB
eurjchem-1346	329	58	plate	plate	NOUN
eurjchem-1346	329	59	(	(	PUNCT
eurjchem-1346	329	60	pierce	pierce	PROPN
eurjchem-1346	329	61	biotechnology	biotechnology	PROPN
eurjchem-1346	329	62	)	)	PUNCT
eurjchem-1346	329	63	.	.	PUNCT
eurjchem-1346	330	1	one	one	NUM
eurjchem-1346	330	2	microliter	microliter	NOUN
eurjchem-1346	330	3	of	of	ADP
eurjchem-1346	330	4	compound	compound	NOUN
eurjchem-1346	330	5	(	(	PUNCT
eurjchem-1346	330	6	as	as	ADP
eurjchem-1346	330	7	racemic	racemic	ADJ
eurjchem-1346	330	8	mixtures	mixture	NOUN
eurjchem-1346	330	9	)	)	PUNCT
eurjchem-1346	330	10	with	with	ADP
eurjchem-1346	330	11	2	2	NUM
eurjchem-1346	330	12	serial	serial	ADJ
eurjchem-1346	330	13	dilutions	dilution	NOUN
eurjchem-1346	330	14	in	in	ADP
eurjchem-1346	330	15	a	a	DET
eurjchem-1346	330	16	100	100	NUM
eurjchem-1346	330	17	%	%	NOUN
eurjchem-1346	330	18	dmso	dmso	ADJ
eurjchem-1346	330	19	stock	stock	NOUN
eurjchem-1346	330	20	solution	solution	NOUN
eurjchem-1346	330	21	was	be	AUX
eurjchem-1346	330	22	added	add	VERB
eurjchem-1346	330	23	to	to	ADP
eurjchem-1346	330	24	a	a	DET
eurjchem-1346	330	25	mixture	mixture	NOUN
eurjchem-1346	330	26	of	of	ADP
eurjchem-1346	330	27	50	50	NUM
eurjchem-1346	330	28	μl	μl	ADP
eurjchem-1346	330	29	of	of	ADP
eurjchem-1346	330	30	a	a	DET
eurjchem-1346	330	31	buffer	buffer	NOUN
eurjchem-1346	330	32	containing	contain	VERB
eurjchem-1346	330	33	50	50	NUM
eurjchem-1346	330	34	mm	mm	NOUN
eurjchem-1346	330	35	hepes	hepe	NOUN
eurjchem-1346	330	36	(	(	PUNCT
eurjchem-1346	330	37	ph	ph	NOUN
eurjchem-1346	330	38	=	=	NOUN
eurjchem-1346	330	39	7.0	7.0	NUM
eurjchem-1346	330	40	)	)	PUNCT
eurjchem-1346	330	41	with	with	ADP
eurjchem-1346	330	42	0.7	0.7	NUM
eurjchem-1346	330	43	pmol	pmol	NOUN
eurjchem-1346	330	44	of	of	ADP
eurjchem-1346	330	45	v600ebraf	v600ebraf	NOUN
eurjchem-1346	330	46	kinase	kinase	PROPN
eurjchem-1346	330	47	.	.	PUNCT
eurjchem-1346	331	1	this	this	DET
eurjchem-1346	331	2	mixture	mixture	NOUN
eurjchem-1346	331	3	was	be	AUX
eurjchem-1346	331	4	incubated	incubate	VERB
eurjchem-1346	331	5	at	at	ADP
eurjchem-1346	331	6	room	room	NOUN
eurjchem-1346	331	7	temperature	temperature	NOUN
eurjchem-1346	331	8	for	for	ADP
eurjchem-1346	331	9	1	1	NUM
eurjchem-1346	331	10	h	h	NOUN
eurjchem-1346	331	11	before	before	SCONJ
eurjchem-1346	331	12	it	it	PRON
eurjchem-1346	331	13	was	be	AUX
eurjchem-1346	331	14	added	add	VERB
eurjchem-1346	331	15	to	to	ADP
eurjchem-1346	331	16	the	the	DET
eurjchem-1346	331	17	gst‐mek‐his‐bound	gst‐mek‐his‐bound	PROPN
eurjchem-1346	331	18	wells	well	NOUN
eurjchem-1346	331	19	of	of	ADP
eurjchem-1346	331	20	the	the	DET
eurjchem-1346	331	21	96‐well	96‐well	NUM
eurjchem-1346	331	22	plate	plate	NOUN
eurjchem-1346	331	23	.	.	PUNCT
eurjchem-1346	332	1	an	an	DET
eurjchem-1346	332	2	additional	additional	ADJ
eurjchem-1346	332	3	50	50	NUM
eurjchem-1346	332	4	μl	μl	ADP
eurjchem-1346	332	5	of	of	ADP
eurjchem-1346	332	6	phosphorylation	phosphorylation	NOUN
eurjchem-1346	332	7	buffer	buffer	NOUN
eurjchem-1346	332	8	(	(	PUNCT
eurjchem-1346	332	9	50	50	NUM
eurjchem-1346	332	10	mm	mm	NOUN
eurjchem-1346	332	11	hepes	hepe	NOUN
eurjchem-1346	332	12	(	(	PUNCT
eurjchem-1346	332	13	ph	ph	NOUN
eurjchem-1346	332	14	=	=	NOUN
eurjchem-1346	332	15	7.0	7.0	NUM
eurjchem-1346	332	16	)	)	PUNCT
eurjchem-1346	332	17	,	,	PUNCT
eurjchem-1346	332	18	200	200	NUM
eurjchem-1346	332	19	mm	mm	NOUN
eurjchem-1346	332	20	nacl	nacl	NOUN
eurjchem-1346	332	21	,	,	PUNCT
eurjchem-1346	332	22	10	10	NUM
eurjchem-1346	332	23	mm	mm	NOUN
eurjchem-1346	332	24	mgcl2	mgcl2	PROPN
eurjchem-1346	332	25	,	,	PUNCT
eurjchem-1346	332	26	and	and	CCONJ
eurjchem-1346	332	27	200	200	NUM
eurjchem-1346	332	28	μm	μm	NUM
eurjchem-1346	332	29	atp	atp	NOUN
eurjchem-1346	332	30	)	)	PUNCT
eurjchem-1346	332	31	was	be	AUX
eurjchem-1346	332	32	added	add	VERB
eurjchem-1346	332	33	to	to	ADP
eurjchem-1346	332	34	the	the	DET
eurjchem-1346	332	35	well	well	ADJ
eurjchem-1346	332	36	mixture	mixture	NOUN
eurjchem-1346	332	37	to	to	PART
eurjchem-1346	332	38	start	start	VERB
eurjchem-1346	332	39	the	the	DET
eurjchem-1346	332	40	kinase	kinase	PROPN
eurjchem-1346	332	41	reaction	reaction	NOUN
eurjchem-1346	332	42	at	at	ADP
eurjchem-1346	332	43	37	37	NUM
eurjchem-1346	332	44	°	°	NOUN
eurjchem-1346	332	45	c	c	NOUN
eurjchem-1346	332	46	for	for	ADP
eurjchem-1346	332	47	30	30	NUM
eurjchem-1346	332	48	min	min	NOUN
eurjchem-1346	332	49	.	.	PROPN
eurjchem-1346	332	50	with	with	ADP
eurjchem-1346	332	51	intermittent	intermittent	ADJ
eurjchem-1346	332	52	shaking	shaking	NOUN
eurjchem-1346	332	53	.	.	PUNCT
eurjchem-1346	333	1	the	the	DET
eurjchem-1346	333	2	kinase	kinase	PROPN
eurjchem-1346	333	3	reaction	reaction	NOUN
eurjchem-1346	333	4	was	be	AUX
eurjchem-1346	333	5	stopped	stop	VERB
eurjchem-1346	333	6	by	by	ADP
eurjchem-1346	333	7	extensive	extensive	ADJ
eurjchem-1346	333	8	washing	washing	NOUN
eurjchem-1346	333	9	with	with	ADP
eurjchem-1346	333	10	ttbs	ttbs	NOUN
eurjchem-1346	333	11	buffer	buffer	NOUN
eurjchem-1346	333	12	,	,	PUNCT
eurjchem-1346	333	13	and	and	CCONJ
eurjchem-1346	333	14	a	a	DET
eurjchem-1346	333	15	1:5000	1:5000	NUM
eurjchem-1346	333	16	dilution	dilution	NOUN
eurjchem-1346	333	17	of	of	ADP
eurjchem-1346	333	18	anti‐phospho‐mek1	anti‐phospho‐mek1	NOUN
eurjchem-1346	333	19	(	(	PUNCT
eurjchem-1346	333	20	ser218/222)/mek2	ser218/222)/mek2	PROPN
eurjchem-1346	333	21	(	(	PUNCT
eurjchem-1346	333	22	ser222/226	ser222/226	NOUN
eurjchem-1346	333	23	)	)	PUNCT
eurjchem-1346	333	24	monoclonal	monoclonal	NOUN
eurjchem-1346	333	25	antibody	antibody	NOUN
eurjchem-1346	333	26	(	(	PUNCT
eurjchem-1346	333	27	millipore	millipore	NOUN
eurjchem-1346	333	28	)	)	PUNCT
eurjchem-1346	333	29	in	in	ADP
eurjchem-1346	333	30	ttbs	ttbs	NOUN
eurjchem-1346	333	31	buffer	buffer	NOUN
eurjchem-1346	333	32	was	be	AUX
eurjchem-1346	333	33	subsequently	subsequently	ADV
eurjchem-1346	333	34	added	add	VERB
eurjchem-1346	333	35	to	to	ADP
eurjchem-1346	333	36	the	the	DET
eurjchem-1346	333	37	wells	well	NOUN
eurjchem-1346	333	38	and	and	CCONJ
eurjchem-1346	333	39	incubated	incubate	VERB
eurjchem-1346	333	40	for	for	ADP
eurjchem-1346	333	41	1	1	NUM
eurjchem-1346	333	42	h	h	NOUN
eurjchem-1346	333	43	with	with	ADP
eurjchem-1346	333	44	shaking	shake	VERB
eurjchem-1346	333	45	.	.	PUNCT
eurjchem-1346	334	1	goat	goat	PROPN
eurjchem-1346	334	2	anti‐rabbit	anti‐rabbit	PROPN
eurjchem-1346	334	3	igg	igg	PROPN
eurjchem-1346	334	4	(	(	PUNCT
eurjchem-1346	334	5	h+l)‐hrp	h+l)‐hrp	ADV
eurjchem-1346	334	6	conjugate	conjugate	ADJ
eurjchem-1346	334	7	(	(	PUNCT
eurjchem-1346	334	8	bio‐rad	bio‐rad	NOUN
eurjchem-1346	334	9	laboratories	laboratory	NOUN
eurjchem-1346	334	10	)	)	PUNCT
eurjchem-1346	334	11	in	in	ADP
eurjchem-1346	334	12	a	a	DET
eurjchem-1346	334	13	1:5000	1:5000	NUM
eurjchem-1346	334	14	dilution	dilution	NOUN
eurjchem-1346	334	15	was	be	AUX
eurjchem-1346	334	16	added	add	VERB
eurjchem-1346	334	17	to	to	ADP
eurjchem-1346	334	18	the	the	DET
eurjchem-1346	334	19	wells	well	NOUN
eurjchem-1346	334	20	for	for	ADP
eurjchem-1346	334	21	incubation	incubation	NOUN
eurjchem-1346	334	22	at	at	ADP
eurjchem-1346	334	23	room	room	NOUN
eurjchem-1346	334	24	temperature	temperature	NOUN
eurjchem-1346	334	25	with	with	ADP
eurjchem-1346	334	26	shaking	shake	VERB
eurjchem-1346	334	27	.	.	PUNCT
eurjchem-1346	335	1	finally	finally	ADV
eurjchem-1346	335	2	,	,	PUNCT
eurjchem-1346	335	3	the	the	DET
eurjchem-1346	335	4	super	super	PROPN
eurjchem-1346	335	5	signal	signal	PROPN
eurjchem-1346	335	6	elisa	elisa	PROPN
eurjchem-1346	335	7	pico	pico	NOUN
eurjchem-1346	335	8	chemiluminescent	chemiluminescent	NOUN
eurjchem-1346	335	9	substrate	substrate	NOUN
eurjchem-1346	335	10	(	(	PUNCT
eurjchem-1346	335	11	pierce	pierce	PROPN
eurjchem-1346	335	12	biotechnology	biotechnology	PROPN
eurjchem-1346	335	13	)	)	PUNCT
eurjchem-1346	335	14	was	be	AUX
eurjchem-1346	335	15	added	add	VERB
eurjchem-1346	335	16	to	to	ADP
eurjchem-1346	335	17	the	the	DET
eurjchem-1346	335	18	wells	well	NOUN
eurjchem-1346	335	19	.	.	PUNCT
eurjchem-1346	336	1	the	the	DET
eurjchem-1346	336	2	luminescence	luminescence	NOUN
eurjchem-1346	336	3	signal	signal	NOUN
eurjchem-1346	336	4	was	be	AUX
eurjchem-1346	336	5	recorded	record	VERB
eurjchem-1346	336	6	with	with	ADP
eurjchem-1346	336	7	a	a	DET
eurjchem-1346	336	8	luminescence	luminescence	NOUN
eurjchem-1346	336	9	filter	filter	NOUN
eurjchem-1346	336	10	using	use	VERB
eurjchem-1346	336	11	a	a	DET
eurjchem-1346	336	12	wallac	wallac	ADJ
eurjchem-1346	336	13	1420	1420	NUM
eurjchem-1346	336	14	luminometer	luminometer	NOUN
eurjchem-1346	336	15	(	(	PUNCT
eurjchem-1346	336	16	perkinelmer	perkinelmer	NOUN
eurjchem-1346	336	17	)	)	PUNCT
eurjchem-1346	337	1	[	[	X
eurjchem-1346	337	2	25	25	NUM
eurjchem-1346	337	3	]	]	PUNCT
eurjchem-1346	337	4	.	.	PUNCT
eurjchem-1346	338	1	high	high	ADJ
eurjchem-1346	338	2	throughput	throughput	NOUN
eurjchem-1346	338	3	inhibitor	inhibitor	NOUN
eurjchem-1346	338	4	screening	screening	NOUN
eurjchem-1346	338	5	was	be	AUX
eurjchem-1346	338	6	performed	perform	VERB
eurjchem-1346	338	7	.	.	PUNCT
eurjchem-1346	339	1	assays	assay	NOUN
eurjchem-1346	339	2	were	be	AUX
eurjchem-1346	339	3	conducted	conduct	VERB
eurjchem-1346	339	4	in	in	ADP
eurjchem-1346	339	5	glutathione	glutathione	NOUN
eurjchem-1346	339	6	coated	coat	VERB
eurjchem-1346	339	7	384‐well	384‐well	NUM
eurjchem-1346	339	8	plates	plate	NOUN
eurjchem-1346	339	9	and	and	CCONJ
eurjchem-1346	339	10	followed	follow	VERB
eurjchem-1346	339	11	the	the	DET
eurjchem-1346	339	12	procedures	procedure	NOUN
eurjchem-1346	339	13	essentially	essentially	ADV
eurjchem-1346	339	14	as	as	SCONJ
eurjchem-1346	339	15	described	describe	VERB
eurjchem-1346	339	16	above	above	ADV
eurjchem-1346	339	17	but	but	CCONJ
eurjchem-1346	339	18	using	use	VERB
eurjchem-1346	339	19	a	a	DET
eurjchem-1346	339	20	50	50	NUM
eurjchem-1346	339	21	μl	μl	DET
eurjchem-1346	339	22	reaction	reaction	NOUN
eurjchem-1346	339	23	volume	volume	NOUN
eurjchem-1346	339	24	instead	instead	ADV
eurjchem-1346	339	25	of	of	ADP
eurjchem-1346	339	26	a	a	DET
eurjchem-1346	339	27	100	100	NUM
eurjchem-1346	339	28	μl	μl	PRON
eurjchem-1346	339	29	reaction	reaction	NOUN
eurjchem-1346	339	30	volume	volume	NOUN
eurjchem-1346	339	31	to	to	PART
eurjchem-1346	339	32	fit	fit	VERB
eurjchem-1346	339	33	384‐well	384‐well	PROPN
eurjchem-1346	339	34	plate	plate	NOUN
eurjchem-1346	339	35	format	format	NOUN
eurjchem-1346	339	36	.	.	PUNCT
eurjchem-1346	340	1	specifically	specifically	ADV
eurjchem-1346	340	2	,	,	PUNCT
eurjchem-1346	340	3	gst‐mek	gst‐mek	PRON
eurjchem-1346	340	4	protein	protein	NOUN
eurjchem-1346	340	5	diluted	dilute	VERB
eurjchem-1346	340	6	in	in	ADP
eurjchem-1346	340	7	ttbs	ttbs	NOUN
eurjchem-1346	340	8	to	to	ADP
eurjchem-1346	340	9	50	50	NUM
eurjchem-1346	340	10	μg	μg	NOUN
eurjchem-1346	340	11	/	/	SYM
eurjchem-1346	340	12	ml	ml	PROPN
eurjchem-1346	340	13	was	be	AUX
eurjchem-1346	340	14	dispensed	dispense	VERB
eurjchem-1346	340	15	into	into	ADP
eurjchem-1346	340	16	the	the	DET
eurjchem-1346	340	17	wells	well	NOUN
eurjchem-1346	340	18	of	of	ADP
eurjchem-1346	340	19	the	the	DET
eurjchem-1346	340	20	glutathione	glutathione	NOUN
eurjchem-1346	340	21	coated	coat	VERB
eurjchem-1346	340	22	384‐well	384‐well	NUM
eurjchem-1346	340	23	plate	plate	NOUN
eurjchem-1346	340	24	to	to	ADP
eurjchem-1346	340	25	a	a	DET
eurjchem-1346	340	26	final	final	ADJ
eurjchem-1346	340	27	volume	volume	NOUN
eurjchem-1346	340	28	of	of	ADP
eurjchem-1346	340	29	50	50	NUM
eurjchem-1346	340	30	μl	μl	PRON
eurjchem-1346	340	31	/	/	SYM
eurjchem-1346	340	32	well	well	ADV
eurjchem-1346	340	33	using	use	VERB
eurjchem-1346	340	34	a	a	DET
eurjchem-1346	340	35	matrix	matrix	NOUN
eurjchem-1346	340	36	wellmate	wellmate	NOUN
eurjchem-1346	340	37	dispanser	dispanser	NOUN
eurjchem-1346	340	38	with	with	ADP
eurjchem-1346	340	39	a	a	DET
eurjchem-1346	340	40	microplate	microplate	NOUN
eurjchem-1346	340	41	stacker	stacker	NOUN
eurjchem-1346	340	42	(	(	PUNCT
eurjchem-1346	340	43	thermo	thermo	NOUN
eurjchem-1346	340	44	scientific	scientific	NOUN
eurjchem-1346	340	45	)	)	PUNCT
eurjchem-1346	340	46	.	.	PUNCT
eurjchem-1346	341	1	each	each	DET
eurjchem-1346	341	2	plate	plate	NOUN
eurjchem-1346	341	3	was	be	AUX
eurjchem-1346	341	4	agitated	agitate	VERB
eurjchem-1346	341	5	using	use	VERB
eurjchem-1346	341	6	an	an	DET
eurjchem-1346	341	7	orbital	orbital	ADJ
eurjchem-1346	341	8	shaker	shaker	NOUN
eurjchem-1346	341	9	at	at	ADP
eurjchem-1346	341	10	2500	2500	NUM
eurjchem-1346	341	11	rpm	rpm	NOUN
eurjchem-1346	341	12	for	for	ADP
eurjchem-1346	341	13	1	1	NUM
eurjchem-1346	341	14	min	min	NOUN
eurjchem-1346	341	15	.	.	PROPN
eurjchem-1346	341	16	and	and	CCONJ
eurjchem-1346	341	17	incubated	incubate	VERB
eurjchem-1346	341	18	at	at	ADP
eurjchem-1346	341	19	room	room	NOUN
eurjchem-1346	341	20	temperature	temperature	NOUN
eurjchem-1346	341	21	for	for	ADP
eurjchem-1346	341	22	1	1	NUM
eurjchem-1346	341	23	h.	h.	NOUN
eurjchem-1346	341	24	plates	plate	NOUN
eurjchem-1346	341	25	were	be	AUX
eurjchem-1346	341	26	aspirated	aspirate	VERB
eurjchem-1346	341	27	and	and	CCONJ
eurjchem-1346	341	28	washed	wash	VERB
eurjchem-1346	341	29	once	once	ADV
eurjchem-1346	341	30	using	use	VERB
eurjchem-1346	341	31	a	a	DET
eurjchem-1346	341	32	wash	wash	NOUN
eurjchem-1346	341	33	program	program	NOUN
eurjchem-1346	341	34	with	with	ADP
eurjchem-1346	341	35	vigorous	vigorous	ADJ
eurjchem-1346	341	36	agitation	agitation	NOUN
eurjchem-1346	341	37	using	use	VERB
eurjchem-1346	341	38	an	an	DET
eurjchem-1346	341	39	automated	automate	VERB
eurjchem-1346	341	40	microplate	microplate	NOUN
eurjchem-1346	341	41	washer	washer	NOUN
eurjchem-1346	341	42	(	(	PUNCT
eurjchem-1346	341	43	biotek	biotek	NOUN
eurjchem-1346	341	44	)	)	PUNCT
eurjchem-1346	341	45	.	.	PUNCT
eurjchem-1346	342	1	3.5	3.5	NUM
eurjchem-1346	342	2	pico	pico	NOUN
eurjchem-1346	342	3	moles	mole	NOUN
eurjchem-1346	342	4	of	of	ADP
eurjchem-1346	342	5	v600ebraf	v600ebraf	NOUN
eurjchem-1346	342	6	kinase	kinase	PROPN
eurjchem-1346	342	7	domain	domain	NOUN
eurjchem-1346	342	8	diluted	dilute	VERB
eurjchem-1346	342	9	in	in	ADP
eurjchem-1346	342	10	25	25	NUM
eurjchem-1346	342	11	μl	μl	ADP
eurjchem-1346	342	12	of	of	ADP
eurjchem-1346	342	13	50	50	NUM
eurjchem-1346	342	14	mm	mm	NOUN
eurjchem-1346	342	15	hepes	hepe	NOUN
eurjchem-1346	342	16	(	(	PUNCT
eurjchem-1346	342	17	4‐(2‐hydroxyethyl)‐1‐piperazineethanesulfonic	4‐(2‐hydroxyethyl)‐1‐piperazineethanesulfonic	NOUN
eurjchem-1346	342	18	acid	acid	NOUN
eurjchem-1346	342	19	)	)	PUNCT
eurjchem-1346	342	20	)	)	PUNCT
eurjchem-1346	342	21	ph	ph	NOUN
eurjchem-1346	342	22	=	=	SYM
eurjchem-1346	342	23	7.5	7.5	NUM
eurjchem-1346	342	24	buffer	buffer	NOUN
eurjchem-1346	342	25	was	be	AUX
eurjchem-1346	342	26	added	add	VERB
eurjchem-1346	342	27	into	into	ADP
eurjchem-1346	342	28	each	each	DET
eurjchem-1346	342	29	well	well	NOUN
eurjchem-1346	342	30	of	of	ADP
eurjchem-1346	342	31	the	the	DET
eurjchem-1346	342	32	plate	plate	NOUN
eurjchem-1346	342	33	using	use	VERB
eurjchem-1346	342	34	the	the	DET
eurjchem-1346	342	35	matrix	matrix	NOUN
eurjchem-1346	342	36	wellmate	wellmate	NOUN
eurjchem-1346	342	37	dispanser	dispanser	NOUN
eurjchem-1346	342	38	,	,	PUNCT
eurjchem-1346	342	39	and	and	CCONJ
eurjchem-1346	342	40	25	25	NUM
eurjchem-1346	342	41	nl	nl	NOUN
eurjchem-1346	342	42	of	of	ADP
eurjchem-1346	342	43	individual	individual	ADJ
eurjchem-1346	342	44	compound	compound	NOUN
eurjchem-1346	342	45	(	(	PUNCT
eurjchem-1346	342	46	10	10	NUM
eurjchem-1346	342	47	mm	mm	NOUN
eurjchem-1346	342	48	in	in	ADP
eurjchem-1346	342	49	100	100	NUM
eurjchem-1346	342	50	%	%	NOUN
eurjchem-1346	342	51	dmso	dmso	NOUN
eurjchem-1346	342	52	)	)	PUNCT
eurjchem-1346	342	53	was	be	AUX
eurjchem-1346	342	54	transferred	transfer	VERB
eurjchem-1346	342	55	into	into	ADP
eurjchem-1346	342	56	the	the	DET
eurjchem-1346	342	57	solution	solution	NOUN
eurjchem-1346	342	58	using	use	VERB
eurjchem-1346	342	59	a	a	DET
eurjchem-1346	342	60	cybi‐well	cybi‐well	NOUN
eurjchem-1346	342	61	pin‐transfer	pin‐transfer	NOUN
eurjchem-1346	342	62	station	station	NOUN
eurjchem-1346	342	63	(	(	PUNCT
eurjchem-1346	342	64	cybio	cybio	PROPN
eurjchem-1346	342	65	)	)	PUNCT
eurjchem-1346	342	66	.	.	PUNCT
eurjchem-1346	343	1	plates	plate	NOUN
eurjchem-1346	343	2	were	be	AUX
eurjchem-1346	343	3	agitated	agitate	VERB
eurjchem-1346	343	4	using	use	VERB
eurjchem-1346	343	5	an	an	DET
eurjchem-1346	343	6	orbital	orbital	ADJ
eurjchem-1346	343	7	shaker	shaker	NOUN
eurjchem-1346	343	8	for	for	ADP
eurjchem-1346	343	9	1	1	NUM
eurjchem-1346	343	10	min	min	NOUN
eurjchem-1346	343	11	and	and	CCONJ
eurjchem-1346	343	12	incubated	incubate	VERB
eurjchem-1346	343	13	at	at	ADP
eurjchem-1346	343	14	room	room	NOUN
eurjchem-1346	343	15	temperature	temperature	NOUN
eurjchem-1346	343	16	for	for	ADP
eurjchem-1346	343	17	1	1	NUM
eurjchem-1346	343	18	h.	h.	NOUN
eurjchem-1346	343	19	25	25	NUM
eurjchem-1346	343	20	μl	μl	ADP
eurjchem-1346	343	21	of	of	ADP
eurjchem-1346	343	22	phosphorylation	phosphorylation	NOUN
eurjchem-1346	343	23	buffer	buffer	NOUN
eurjchem-1346	343	24	was	be	AUX
eurjchem-1346	343	25	then	then	ADV
eurjchem-1346	343	26	added	add	VERB
eurjchem-1346	343	27	into	into	ADP
eurjchem-1346	343	28	the	the	DET
eurjchem-1346	343	29	wells	well	NOUN
eurjchem-1346	343	30	to	to	PART
eurjchem-1346	343	31	start	start	VERB
eurjchem-1346	343	32	the	the	DET
eurjchem-1346	343	33	kinase	kinase	PROPN
eurjchem-1346	343	34	reaction	reaction	NOUN
eurjchem-1346	343	35	(	(	PUNCT
eurjchem-1346	343	36	controls	control	NOUN
eurjchem-1346	343	37	were	be	AUX
eurjchem-1346	343	38	tested	test	VERB
eurjchem-1346	343	39	to	to	PART
eurjchem-1346	343	40	ensure	ensure	VERB
eurjchem-1346	343	41	the	the	DET
eurjchem-1346	343	42	precise	precise	ADJ
eurjchem-1346	343	43	timing	timing	NOUN
eurjchem-1346	343	44	for	for	ADP
eurjchem-1346	343	45	the	the	DET
eurjchem-1346	343	46	start	start	NOUN
eurjchem-1346	343	47	of	of	ADP
eurjchem-1346	343	48	the	the	DET
eurjchem-1346	343	49	kinase	kinase	PROPN
eurjchem-1346	343	50	reaction	reaction	NOUN
eurjchem-1346	343	51	)	)	PUNCT
eurjchem-1346	343	52	.	.	PUNCT
eurjchem-1346	344	1	kinase	kinase	PROPN
eurjchem-1346	344	2	reactions	reaction	NOUN
eurjchem-1346	344	3	were	be	AUX
eurjchem-1346	344	4	conducted	conduct	VERB
eurjchem-1346	344	5	at	at	ADP
eurjchem-1346	344	6	room	room	NOUN
eurjchem-1346	344	7	temperature	temperature	NOUN
eurjchem-1346	344	8	for	for	ADP
eurjchem-1346	344	9	30	30	NUM
eurjchem-1346	344	10	min	min	NOUN
eurjchem-1346	344	11	and	and	CCONJ
eurjchem-1346	344	12	stopped	stop	VERB
eurjchem-1346	344	13	by	by	ADP
eurjchem-1346	344	14	washing	washing	NOUN
eurjchem-1346	344	15	using	use	VERB
eurjchem-1346	344	16	the	the	DET
eurjchem-1346	344	17	microplate	microplate	NOUN
eurjchem-1346	344	18	washer	washer	NOUN
eurjchem-1346	344	19	.	.	PUNCT
eurjchem-1346	345	1	a	a	DET
eurjchem-1346	345	2	1:5000	1:5000	NUM
eurjchem-1346	345	3	dilution	dilution	NOUN
eurjchem-1346	345	4	of	of	ADP
eurjchem-1346	345	5	anti‐phospho‐	anti‐phospho‐	PRON
eurjchem-1346	345	6	mek1	mek1	NOUN
eurjchem-1346	345	7	(	(	PUNCT
eurjchem-1346	345	8	ser218/222)/mek2	ser218/222)/mek2	PROPN
eurjchem-1346	345	9	(	(	PUNCT
eurjchem-1346	345	10	ser222/226	ser222/226	NOUN
eurjchem-1346	345	11	)	)	PUNCT
eurjchem-1346	345	12	monoclonal	monoclonal	NOUN
eurjchem-1346	345	13	antibody	antibody	NOUN
eurjchem-1346	345	14	(	(	PUNCT
eurjchem-1346	345	15	millipore	millipore	NOUN
eurjchem-1346	345	16	)	)	PUNCT
eurjchem-1346	345	17	in	in	ADP
eurjchem-1346	345	18	ttbs	ttbs	NOUN
eurjchem-1346	345	19	buffer	buffer	NOUN
eurjchem-1346	345	20	was	be	AUX
eurjchem-1346	345	21	subsequently	subsequently	ADV
eurjchem-1346	345	22	dispensed	dispense	VERB
eurjchem-1346	345	23	into	into	ADP
eurjchem-1346	345	24	the	the	DET
eurjchem-1346	345	25	wells	well	NOUN
eurjchem-1346	345	26	to	to	ADP
eurjchem-1346	345	27	a	a	DET
eurjchem-1346	345	28	final	final	ADJ
eurjchem-1346	345	29	volume	volume	NOUN
eurjchem-1346	345	30	of	of	ADP
eurjchem-1346	345	31	50	50	NUM
eurjchem-1346	345	32	μl	μl	ADV
eurjchem-1346	345	33	and	and	CCONJ
eurjchem-1346	345	34	incubated	incubate	VERB
eurjchem-1346	345	35	for	for	ADP
eurjchem-1346	345	36	1	1	NUM
eurjchem-1346	345	37	h	h	NOUN
eurjchem-1346	345	38	with	with	ADP
eurjchem-1346	345	39	shaking	shake	VERB
eurjchem-1346	345	40	.	.	PUNCT
eurjchem-1346	346	1	goat	goat	PROPN
eurjchem-1346	346	2	anti‐rabbit	anti‐rabbit	PROPN
eurjchem-1346	346	3	igg	igg	PROPN
eurjchem-1346	346	4	(	(	PUNCT
eurjchem-1346	346	5	h+l)‐hrp	h+l)‐hrp	ADV
eurjchem-1346	346	6	conjugate	conjugate	ADJ
eurjchem-1346	346	7	(	(	PUNCT
eurjchem-1346	346	8	biorad	biorad	NOUN
eurjchem-1346	346	9	laboratories	laboratory	NOUN
eurjchem-1346	346	10	)	)	PUNCT
eurjchem-1346	346	11	in	in	ADP
eurjchem-1346	346	12	a	a	DET
eurjchem-1346	346	13	1:5000	1:5000	NUM
eurjchem-1346	346	14	dilution	dilution	NOUN
eurjchem-1346	346	15	was	be	AUX
eurjchem-1346	346	16	then	then	ADV
eurjchem-1346	346	17	dispensed	dispense	VERB
eurjchem-1346	346	18	into	into	ADP
eurjchem-1346	346	19	the	the	DET
eurjchem-1346	346	20	wells	well	NOUN
eurjchem-1346	346	21	to	to	ADP
eurjchem-1346	346	22	a	a	DET
eurjchem-1346	346	23	final	final	ADJ
eurjchem-1346	346	24	volume	volume	NOUN
eurjchem-1346	346	25	of	of	ADP
eurjchem-1346	346	26	50	50	NUM
eurjchem-1346	346	27	μl	μl	NOUN
eurjchem-1346	346	28	to	to	PART
eurjchem-1346	346	29	incubate	incubate	VERB
eurjchem-1346	346	30	at	at	ADP
eurjchem-1346	346	31	room	room	NOUN
eurjchem-1346	346	32	temperature	temperature	NOUN
eurjchem-1346	346	33	with	with	ADP
eurjchem-1346	346	34	agitation	agitation	NOUN
eurjchem-1346	346	35	.	.	PUNCT
eurjchem-1346	347	1	finally	finally	ADV
eurjchem-1346	347	2	,	,	PUNCT
eurjchem-1346	347	3	50	50	NUM
eurjchem-1346	347	4	μl	μl	ADP
eurjchem-1346	347	5	of	of	ADP
eurjchem-1346	347	6	the	the	DET
eurjchem-1346	347	7	super	super	PROPN
eurjchem-1346	347	8	signal	signal	PROPN
eurjchem-1346	347	9	elisa	elisa	PROPN
eurjchem-1346	347	10	pico	pico	NOUN
eurjchem-1346	347	11	chemiluminescent	chemiluminescent	NOUN
eurjchem-1346	347	12	substrate	substrate	NOUN
eurjchem-1346	347	13	(	(	PUNCT
eurjchem-1346	347	14	pierce	pierce	PROPN
eurjchem-1346	347	15	biotechnology	biotechnology	PROPN
eurjchem-1346	347	16	)	)	PUNCT
eurjchem-1346	347	17	was	be	AUX
eurjchem-1346	347	18	dispensed	dispense	VERB
eurjchem-1346	347	19	into	into	ADP
eurjchem-1346	347	20	the	the	DET
eurjchem-1346	347	21	wells	well	NOUN
eurjchem-1346	347	22	to	to	PART
eurjchem-1346	347	23	generate	generate	VERB
eurjchem-1346	347	24	the	the	DET
eurjchem-1346	347	25	chemiluminescence	chemiluminescence	NOUN
eurjchem-1346	347	26	signal	signal	NOUN
eurjchem-1346	347	27	,	,	PUNCT
eurjchem-1346	347	28	which	which	PRON
eurjchem-1346	347	29	was	be	AUX
eurjchem-1346	347	30	detected	detect	VERB
eurjchem-1346	347	31	using	use	VERB
eurjchem-1346	347	32	a	a	DET
eurjchem-1346	347	33	700	700	NUM
eurjchem-1346	347	34	nm	nm	ADJ
eurjchem-1346	347	35	luminescence	luminescence	NOUN
eurjchem-1346	347	36	filter	filter	NOUN
eurjchem-1346	347	37	by	by	ADP
eurjchem-1346	347	38	an	an	DET
eurjchem-1346	347	39	envision	envision	NOUN
eurjchem-1346	347	40	chemiluminescence	chemiluminescence	NOUN
eurjchem-1346	347	41	detector	detector	NOUN
eurjchem-1346	347	42	(	(	PUNCT
eurjchem-1346	347	43	perkinelmer	perkinelmer	NOUN
eurjchem-1346	347	44	)	)	PUNCT
eurjchem-1346	347	45	.	.	PUNCT
eurjchem-1346	348	1	a	a	DET
eurjchem-1346	348	2	total	total	NOUN
eurjchem-1346	348	3	of	of	ADP
eurjchem-1346	348	4	31976	31976	NUM
eurjchem-1346	348	5	compounds	compound	NOUN
eurjchem-1346	348	6	were	be	AUX
eurjchem-1346	348	7	screened	screen	VERB
eurjchem-1346	348	8	in	in	ADP
eurjchem-1346	348	9	duplicate	duplicate	NOUN
eurjchem-1346	348	10	including	include	VERB
eurjchem-1346	348	11	libraries	library	NOUN
eurjchem-1346	348	12	of	of	ADP
eurjchem-1346	348	13	a	a	DET
eurjchem-1346	348	14	diversity	diversity	NOUN
eurjchem-1346	348	15	oriented	orient	VERB
eurjchem-1346	348	16	synthesis	synthesis	NOUN
eurjchem-1346	348	17	(	(	PUNCT
eurjchem-1346	348	18	dos	do	NOUN
eurjchem-1346	348	19	)	)	PUNCT
eurjchem-1346	348	20	,	,	PUNCT
eurjchem-1346	348	21	commercially	commercially	ADV
eurjchem-1346	348	22	available	available	ADJ
eurjchem-1346	348	23	drug‐like	drug‐like	NOUN
eurjchem-1346	348	24	compounds	compound	NOUN
eurjchem-1346	348	25	,	,	PUNCT
eurjchem-1346	348	26	bioactive	bioactive	PROPN
eurjchem-1346	348	27	compounds	compound	NOUN
eurjchem-1346	348	28	,	,	PUNCT
eurjchem-1346	348	29	natural	natural	ADJ
eurjchem-1346	348	30	products	product	NOUN
eurjchem-1346	348	31	,	,	PUNCT
eurjchem-1346	348	32	compounds	compound	NOUN
eurjchem-1346	348	33	collected	collect	VERB
eurjchem-1346	348	34	from	from	ADP
eurjchem-1346	348	35	academic	academic	ADJ
eurjchem-1346	348	36	organic	organic	ADJ
eurjchem-1346	348	37	synthesis	synthesis	NOUN
eurjchem-1346	348	38	laboratories	laboratory	NOUN
eurjchem-1346	348	39	and	and	CCONJ
eurjchem-1346	348	40	a	a	DET
eurjchem-1346	348	41	chembridge	chembridge	NOUN
eurjchem-1346	348	42	kinase	kinase	PROPN
eurjchem-1346	348	43	inhibitor	inhibitor	PROPN
eurjchem-1346	348	44	biased	bias	VERB
eurjchem-1346	348	45	library	library	NOUN
eurjchem-1346	348	46	.	.	PUNCT
eurjchem-1346	349	1	compounds	compound	NOUN
eurjchem-1346	349	2	were	be	AUX
eurjchem-1346	349	3	ranked	rank	VERB
eurjchem-1346	349	4	based	base	VERB
eurjchem-1346	349	5	on	on	ADP
eurjchem-1346	349	6	a	a	DET
eurjchem-1346	349	7	composite	composite	NOUN
eurjchem-1346	349	8	z‐score	z‐score	ADJ
eurjchem-1346	349	9	of	of	ADP
eurjchem-1346	349	10	both	both	DET
eurjchem-1346	349	11	duplicates	duplicate	NOUN
eurjchem-1346	349	12	and	and	CCONJ
eurjchem-1346	349	13	the	the	DET
eurjchem-1346	349	14	top	top	ADJ
eurjchem-1346	349	15	100	100	NUM
eurjchem-1346	349	16	compounds	compound	NOUN
eurjchem-1346	349	17	were	be	AUX
eurjchem-1346	349	18	cherry‐picked	cherry‐picke	VERB
eurjchem-1346	349	19	from	from	ADP
eurjchem-1346	349	20	the	the	DET
eurjchem-1346	349	21	compound	compound	NOUN
eurjchem-1346	349	22	plates	plate	NOUN
eurjchem-1346	349	23	at	at	ADP
eurjchem-1346	349	24	the	the	DET
eurjchem-1346	349	25	broad	broad	PROPN
eurjchem-1346	349	26	institute	institute	NOUN
eurjchem-1346	349	27	and	and	CCONJ
eurjchem-1346	349	28	they	they	PRON
eurjchem-1346	349	29	were	be	AUX
eurjchem-1346	349	30	re‐	re‐	ADV
eurjchem-1346	349	31	analyzed	analyze	VERB
eurjchem-1346	349	32	by	by	ADP
eurjchem-1346	349	33	the	the	DET
eurjchem-1346	349	34	same	same	ADJ
eurjchem-1346	349	35	assay	assay	NOUN
eurjchem-1346	349	36	to	to	PART
eurjchem-1346	349	37	confirm	confirm	VERB
eurjchem-1346	349	38	their	their	PRON
eurjchem-1346	349	39	inhibitory	inhibitory	ADJ
eurjchem-1346	349	40	activities	activity	NOUN
eurjchem-1346	349	41	.	.	PUNCT
eurjchem-1346	350	1	according	accord	VERB
eurjchem-1346	350	2	to	to	ADP
eurjchem-1346	350	3	the	the	DET
eurjchem-1346	350	4	results	result	NOUN
eurjchem-1346	350	5	,	,	PUNCT
eurjchem-1346	350	6	the	the	DET
eurjchem-1346	350	7	top	top	ADJ
eurjchem-1346	350	8	23	23	NUM
eurjchem-1346	350	9	compounds	compound	NOUN
eurjchem-1346	350	10	that	that	PRON
eurjchem-1346	350	11	were	be	AUX
eurjchem-1346	350	12	deemed	deem	VERB
eurjchem-1346	350	13	to	to	PART
eurjchem-1346	350	14	have	have	VERB
eurjchem-1346	350	15	drug‐like	drug‐like	NOUN
eurjchem-1346	350	16	properties	property	NOUN
eurjchem-1346	350	17	were	be	AUX
eurjchem-1346	350	18	confirmed	confirm	VERB
eurjchem-1346	350	19	by	by	ADP
eurjchem-1346	350	20	reordering	reorder	VERB
eurjchem-1346	350	21	the	the	DET
eurjchem-1346	350	22	compounds	compound	NOUN
eurjchem-1346	350	23	from	from	ADP
eurjchem-1346	350	24	their	their	PRON
eurjchem-1346	350	25	source	source	NOUN
eurjchem-1346	350	26	vendors	vendor	NOUN
eurjchem-1346	350	27	and	and	CCONJ
eurjchem-1346	350	28	confirming	confirm	VERB
eurjchem-1346	350	29	their	their	PRON
eurjchem-1346	350	30	inhibitor	inhibitor	NOUN
eurjchem-1346	350	31	activities	activity	NOUN
eurjchem-1346	350	32	[	[	X
eurjchem-1346	350	33	25	25	NUM
eurjchem-1346	350	34	]	]	PUNCT
eurjchem-1346	350	35	.	.	PUNCT
eurjchem-1346	351	1	2.2.2.3	2.2.2.3	NUM
eurjchem-1346	351	2	.	.	PUNCT
eurjchem-1346	352	1	ic50	ic50	PROPN
eurjchem-1346	352	2	value	value	NOUN
eurjchem-1346	352	3	determination	determination	NOUN
eurjchem-1346	352	4	for	for	ADP
eurjchem-1346	352	5	ic50	ic50	PROPN
eurjchem-1346	352	6	calculations	calculation	NOUN
eurjchem-1346	352	7	of	of	ADP
eurjchem-1346	352	8	the	the	DET
eurjchem-1346	352	9	related	relate	VERB
eurjchem-1346	352	10	quinolol	quinolol	ADJ
eurjchem-1346	352	11	and	and	CCONJ
eurjchem-1346	352	12	naphthol	naphthol	NOUN
eurjchem-1346	352	13	inhibitors	inhibitor	NOUN
eurjchem-1346	352	14	,	,	PUNCT
eurjchem-1346	352	15	the	the	DET
eurjchem-1346	352	16	same	same	ADJ
eurjchem-1346	352	17	assay	assay	NOUN
eurjchem-1346	352	18	described	describe	VERB
eurjchem-1346	352	19	above	above	ADV
eurjchem-1346	352	20	was	be	AUX
eurjchem-1346	352	21	used	use	VERB
eurjchem-1346	352	22	at	at	ADP
eurjchem-1346	352	23	different	different	ADJ
eurjchem-1346	352	24	inhibitor	inhibitor	NOUN
eurjchem-1346	352	25	concentrations	concentration	NOUN
eurjchem-1346	352	26	to	to	PART
eurjchem-1346	352	27	generate	generate	VERB
eurjchem-1346	352	28	a	a	DET
eurjchem-1346	352	29	sigmoidal	sigmoidal	NOUN
eurjchem-1346	352	30	dose	dose	VERB
eurjchem-1346	352	31	response	response	NOUN
eurjchem-1346	352	32	curve	curve	NOUN
eurjchem-1346	352	33	using	use	VERB
eurjchem-1346	352	34	v600ebraf	v600ebraf	NOUN
eurjchem-1346	352	35	or	or	CCONJ
eurjchem-1346	352	36	wtbraf	wtbraf	VERB
eurjchem-1346	352	37	protein	protein	NOUN
eurjchem-1346	352	38	.	.	PUNCT
eurjchem-1346	353	1	all	all	DET
eurjchem-1346	353	2	dose	dose	VERB
eurjchem-1346	353	3	response	response	NOUN
eurjchem-1346	353	4	measurements	measurement	NOUN
eurjchem-1346	353	5	were	be	AUX
eurjchem-1346	353	6	carried	carry	VERB
eurjchem-1346	353	7	out	out	ADP
eurjchem-1346	353	8	in	in	ADP
eurjchem-1346	353	9	duplicate	duplicate	NOUN
eurjchem-1346	353	10	or	or	CCONJ
eurjchem-1346	353	11	triplicate	triplicate	VERB
eurjchem-1346	353	12	and	and	CCONJ
eurjchem-1346	353	13	ic50	ic50	PROPN
eurjchem-1346	353	14	values	value	NOUN
eurjchem-1346	353	15	were	be	AUX
eurjchem-1346	353	16	derived	derive	VERB
eurjchem-1346	353	17	from	from	ADP
eurjchem-1346	353	18	fitting	fit	VERB
eurjchem-1346	353	19	the	the	DET
eurjchem-1346	353	20	data	datum	NOUN
eurjchem-1346	353	21	to	to	ADP
eurjchem-1346	353	22	a	a	DET
eurjchem-1346	353	23	sigmoidal	sigmoidal	NOUN
eurjchem-1346	353	24	dose	dose	VERB
eurjchem-1346	353	25	response	response	NOUN
eurjchem-1346	353	26	curve	curve	NOUN
eurjchem-1346	353	27	with	with	ADP
eurjchem-1346	353	28	a	a	DET
eurjchem-1346	353	29	four‐parameter	four‐parameter	ADJ
eurjchem-1346	353	30	logistic	logistic	ADJ
eurjchem-1346	353	31	model	model	NOUN
eurjchem-1346	353	32	using	use	VERB
eurjchem-1346	353	33	graph	graph	NOUN
eurjchem-1346	353	34	pad	pad	NOUN
eurjchem-1346	353	35	prism	prism	NOUN
eurjchem-1346	353	36	[	[	X
eurjchem-1346	353	37	26	26	NUM
eurjchem-1346	353	38	]	]	PUNCT
eurjchem-1346	353	39	.	.	PUNCT
eurjchem-1346	354	1	ic50	ic50	PROPN
eurjchem-1346	354	2	values	value	NOUN
eurjchem-1346	354	3	were	be	AUX
eurjchem-1346	354	4	calculated	calculate	VERB
eurjchem-1346	354	5	using	use	VERB
eurjchem-1346	354	6	graphpad	graphpad	NOUN
eurjchem-1346	354	7	prism	prism	NOUN
eurjchem-1346	354	8	software	software	NOUN
eurjchem-1346	354	9	(	(	PUNCT
eurjchem-1346	354	10	graphpad	graphpad	NOUN
eurjchem-1346	354	11	software	software	NOUN
eurjchem-1346	354	12	,	,	PUNCT
eurjchem-1346	354	13	la	la	PROPN
eurjchem-1346	354	14	jolla	jolla	PROPN
eurjchem-1346	354	15	,	,	PUNCT
eurjchem-1346	354	16	ca	ca	PROPN
eurjchem-1346	354	17	,	,	PUNCT
eurjchem-1346	354	18	usa	usa	PROPN
eurjchem-1346	354	19	)	)	PUNCT
eurjchem-1346	354	20	.	.	PUNCT
eurjchem-1346	355	1	data	datum	NOUN
eurjchem-1346	355	2	are	be	AUX
eurjchem-1346	355	3	reported	report	VERB
eurjchem-1346	355	4	as	as	SCONJ
eurjchem-1346	355	5	means±sem	means±sem	PROPN
eurjchem-1346	355	6	and	and	CCONJ
eurjchem-1346	355	7	significance	significance	NOUN
eurjchem-1346	355	8	was	be	AUX
eurjchem-1346	355	9	calculated	calculate	VERB
eurjchem-1346	355	10	by	by	ADP
eurjchem-1346	355	11	student	student	NOUN
eurjchem-1346	355	12	's	's	PART
eurjchem-1346	355	13	t‐test	t‐test	PUNCT
eurjchem-1346	355	14	using	use	VERB
eurjchem-1346	355	15	spss	spss	PROPN
eurjchem-1346	355	16	software	software	NOUN
eurjchem-1346	355	17	(	(	PUNCT
eurjchem-1346	355	18	spss	spss	PROPN
eurjchem-1346	355	19	inc	inc	PROPN
eurjchem-1346	355	20	.	.	PROPN
eurjchem-1346	355	21	,	,	PUNCT
eurjchem-1346	355	22	paris	paris	PROPN
eurjchem-1346	355	23	,	,	PUNCT
eurjchem-1346	355	24	france	france	PROPN
eurjchem-1346	355	25	)	)	PUNCT
eurjchem-1346	355	26	.	.	PUNCT
eurjchem-1346	356	1	the	the	DET
eurjchem-1346	356	2	concentrations	concentration	NOUN
eurjchem-1346	356	3	range	range	NOUN
eurjchem-1346	356	4	used	use	VERB
eurjchem-1346	356	5	were	be	AUX
eurjchem-1346	356	6	0.01	0.01	NUM
eurjchem-1346	356	7	,	,	PUNCT
eurjchem-1346	356	8	0.05	0.05	NUM
eurjchem-1346	356	9	,	,	PUNCT
eurjchem-1346	356	10	0.1	0.1	NUM
eurjchem-1346	356	11	,	,	PUNCT
eurjchem-1346	356	12	0.5	0.5	NUM
eurjchem-1346	356	13	1	1	NUM
eurjchem-1346	356	14	,	,	PUNCT
eurjchem-1346	356	15	5	5	NUM
eurjchem-1346	356	16	and	and	CCONJ
eurjchem-1346	356	17	10	10	NUM
eurjchem-1346	356	18	µm	µm	NOUN
eurjchem-1346	356	19	.	.	PROPN
eurjchem-1346	356	20	2.3	2.3	NUM
eurjchem-1346	356	21	.	.	PUNCT
eurjchem-1346	357	1	molecular	molecular	ADJ
eurjchem-1346	357	2	docking	dock	VERB
eurjchem-1346	357	3	2.3.1	2.3.1	NUM
eurjchem-1346	357	4	.	.	PUNCT
eurjchem-1346	357	5	docking	dock	VERB
eurjchem-1346	357	6	procedure	procedure	NOUN
eurjchem-1346	357	7	docking	dock	VERB
eurjchem-1346	357	8	studies	study	NOUN
eurjchem-1346	357	9	of	of	ADP
eurjchem-1346	357	10	all	all	DET
eurjchem-1346	357	11	the	the	DET
eurjchem-1346	357	12	synthesized	synthesize	VERB
eurjchem-1346	357	13	compounds	compound	NOUN
eurjchem-1346	357	14	were	be	AUX
eurjchem-1346	357	15	performed	perform	VERB
eurjchem-1346	357	16	by	by	ADP
eurjchem-1346	357	17	molecular	molecular	ADJ
eurjchem-1346	357	18	operating	operating	NOUN
eurjchem-1346	357	19	environment	environment	NOUN
eurjchem-1346	357	20	(	(	PUNCT
eurjchem-1346	357	21	moe	moe	NOUN
eurjchem-1346	357	22	)	)	PUNCT
eurjchem-1346	358	1	[	[	X
eurjchem-1346	358	2	27	27	NUM
eurjchem-1346	358	3	]	]	PUNCT
eurjchem-1346	358	4	.	.	PUNCT
eurjchem-1346	359	1	the	the	DET
eurjchem-1346	359	2	program	program	NOUN
eurjchem-1346	359	3	operated	operate	VERB
eurjchem-1346	359	4	under	under	ADP
eurjchem-1346	359	5	“	"	PUNCT
eurjchem-1346	359	6	window	window	NOUN
eurjchem-1346	359	7	7	7	NUM
eurjchem-1346	359	8	”	"	PUNCT
eurjchem-1346	359	9	operating	operating	NOUN
eurjchem-1346	359	10	system	system	NOUN
eurjchem-1346	359	11	installed	instal	VERB
eurjchem-1346	359	12	on	on	ADP
eurjchem-1346	359	13	an	an	DET
eurjchem-1346	359	14	dell	dell	NOUN
eurjchem-1346	359	15	pentium	pentium	NOUN
eurjchem-1346	359	16	iv	iv	NUM
eurjchem-1346	359	17	pc	pc	NOUN
eurjchem-1346	359	18	with	with	ADP
eurjchem-1346	359	19	a	a	DET
eurjchem-1346	359	20	2.8	2.8	NUM
eurjchem-1346	359	21	mhz	mhz	NOUN
eurjchem-1346	359	22	processor	processor	NOUN
eurjchem-1346	359	23	and	and	CCONJ
eurjchem-1346	359	24	512	512	NUM
eurjchem-1346	359	25	ram	ram	NOUN
eurjchem-1346	359	26	.	.	PUNCT
eurjchem-1346	360	1	all	all	DET
eurjchem-1346	360	2	minimizations	minimization	NOUN
eurjchem-1346	360	3	were	be	AUX
eurjchem-1346	360	4	performed	perform	VERB
eurjchem-1346	360	5	with	with	ADP
eurjchem-1346	360	6	moe	moe	NOUN
eurjchem-1346	360	7	until	until	SCONJ
eurjchem-1346	360	8	a	a	DET
eurjchem-1346	360	9	rmsd	rmsd	NOUN
eurjchem-1346	360	10	gradient	gradient	NOUN
eurjchem-1346	360	11	of	of	ADP
eurjchem-1346	360	12	0.05	0.05	NUM
eurjchem-1346	360	13	kcal	kcal	NOUN
eurjchem-1346	360	14	/	/	SYM
eurjchem-1346	360	15	mol.å	mol.å	PROPN
eurjchem-1346	360	16	with	with	ADP
eurjchem-1346	360	17	mmff94	mmff94	NOUN
eurjchem-1346	360	18	force	force	PROPN
eurjchem-1346	360	19	field	field	PROPN
eurjchem-1346	360	20	and	and	CCONJ
eurjchem-1346	360	21	the	the	DET
eurjchem-1346	360	22	partial	partial	ADJ
eurjchem-1346	360	23	charges	charge	NOUN
eurjchem-1346	360	24	were	be	AUX
eurjchem-1346	360	25	automatically	automatically	ADV
eurjchem-1346	360	26	calculated	calculate	VERB
eurjchem-1346	360	27	.	.	PUNCT
eurjchem-1346	361	1	the	the	DET
eurjchem-1346	361	2	score	score	NOUN
eurjchem-1346	361	3	function	function	NOUN
eurjchem-1346	361	4	,	,	PUNCT
eurjchem-1346	361	5	dock	dock	NOUN
eurjchem-1346	361	6	function	function	NOUN
eurjchem-1346	361	7	(	(	PUNCT
eurjchem-1346	361	8	s	s	X
eurjchem-1346	361	9	,	,	PUNCT
eurjchem-1346	361	10	kcal	kcal	PROPN
eurjchem-1346	361	11	/	/	SYM
eurjchem-1346	361	12	mol	mol	NOUN
eurjchem-1346	361	13	)	)	PUNCT
eurjchem-1346	361	14	developed	develop	VERB
eurjchem-1346	361	15	by	by	ADP
eurjchem-1346	361	16	moe	moe	NOUN
eurjchem-1346	361	17	program	program	NOUN
eurjchem-1346	361	18	was	be	AUX
eurjchem-1346	361	19	used	use	VERB
eurjchem-1346	361	20	for	for	ADP
eurjchem-1346	361	21	the	the	DET
eurjchem-1346	361	22	evaluation	evaluation	NOUN
eurjchem-1346	361	23	of	of	ADP
eurjchem-1346	361	24	the	the	DET
eurjchem-1346	361	25	binding	bind	VERB
eurjchem-1346	361	26	affinity	affinity	NOUN
eurjchem-1346	361	27	of	of	ADP
eurjchem-1346	361	28	the	the	DET
eurjchem-1346	361	29	ligand	ligand	NOUN
eurjchem-1346	361	30	.	.	PUNCT
eurjchem-1346	362	1	amin	amin	PROPN
eurjchem-1346	362	2	et	et	PROPN
eurjchem-1346	362	3	al	al	PROPN
eurjchem-1346	362	4	.	.	PUNCT
eurjchem-1346	362	5	/	/	SYM
eurjchem-1346	362	6	european	european	PROPN
eurjchem-1346	362	7	journal	journal	PROPN
eurjchem-1346	362	8	of	of	ADP
eurjchem-1346	362	9	chemistry	chemistry	NOUN
eurjchem-1346	362	10	7	7	NUM
eurjchem-1346	362	11	(	(	PUNCT
eurjchem-1346	362	12	1	1	NUM
eurjchem-1346	362	13	)	)	PUNCT
eurjchem-1346	362	14	(	(	PUNCT
eurjchem-1346	362	15	2016	2016	NUM
eurjchem-1346	362	16	)	)	PUNCT
eurjchem-1346	362	17	19‐29	19‐29	NOUN
eurjchem-1346	363	1	25	25	NUM
eurjchem-1346	363	2	2.3.2	2.3.2	NUM
eurjchem-1346	363	3	.	.	PUNCT
eurjchem-1346	363	4	preparation	preparation	NOUN
eurjchem-1346	363	5	of	of	ADP
eurjchem-1346	363	6	the	the	DET
eurjchem-1346	363	7	target	target	NOUN
eurjchem-1346	363	8	v600ebraf	v600ebraf	PROPN
eurjchem-1346	363	9	kinase	kinase	NOUN
eurjchem-1346	363	10	protein	protein	NOUN
eurjchem-1346	363	11	the	the	DET
eurjchem-1346	363	12	x‐ray	x‐ray	PROPN
eurjchem-1346	363	13	crystal	crystal	NOUN
eurjchem-1346	363	14	structure	structure	NOUN
eurjchem-1346	363	15	of	of	ADP
eurjchem-1346	363	16	the	the	DET
eurjchem-1346	363	17	enzyme	enzyme	NOUN
eurjchem-1346	363	18	with	with	ADP
eurjchem-1346	363	19	plx3203	plx3203	NOUN
eurjchem-1346	363	20	,	,	PUNCT
eurjchem-1346	363	21	n‐{2,4‐difluoro‐3‐[(5‐pyridin‐3‐yl‐1h‐pyrrolo[2,3‐b]pyridin‐3‐	n‐{2,4‐difluoro‐3‐[(5‐pyridin‐3‐yl‐1h‐pyrrolo[2,3‐b]pyridin‐3‐	NOUN
eurjchem-1346	363	22	yl)carbonyl]phenyl}ethanesulfonamide	yl)carbonyl]phenyl}ethanesulfonamide	PROPN
eurjchem-1346	363	23	(	(	PUNCT
eurjchem-1346	363	24	pdb	pdb	PROPN
eurjchem-1346	363	25	code	code	PROPN
eurjchem-1346	363	26	:	:	PUNCT
eurjchem-1346	363	27	4fk3	4fk3	NUM
eurjchem-1346	363	28	)	)	PUNCT
eurjchem-1346	364	1	[	[	X
eurjchem-1346	364	2	28	28	NUM
eurjchem-1346	364	3	]	]	PUNCT
eurjchem-1346	364	4	was	be	AUX
eurjchem-1346	364	5	obtained	obtain	VERB
eurjchem-1346	364	6	from	from	ADP
eurjchem-1346	364	7	the	the	DET
eurjchem-1346	364	8	protein	protein	NOUN
eurjchem-1346	364	9	data	datum	NOUN
eurjchem-1346	364	10	bank	bank	NOUN
eurjchem-1346	364	11	(	(	PUNCT
eurjchem-1346	364	12	www.rcsb.org	www.rcsb.org	X
eurjchem-1346	364	13	)	)	PUNCT
eurjchem-1346	364	14	in	in	ADP
eurjchem-1346	364	15	pdb	pdb	PROPN
eurjchem-1346	364	16	format	format	NOUN
eurjchem-1346	364	17	.	.	PUNCT
eurjchem-1346	365	1	the	the	DET
eurjchem-1346	365	2	enzyme	enzyme	NOUN
eurjchem-1346	365	3	was	be	AUX
eurjchem-1346	365	4	prepared	prepare	VERB
eurjchem-1346	365	5	for	for	ADP
eurjchem-1346	365	6	docking	dock	VERB
eurjchem-1346	365	7	studies	study	NOUN
eurjchem-1346	365	8	.	.	PUNCT
eurjchem-1346	366	1	(	(	PUNCT
eurjchem-1346	366	2	i	i	NOUN
eurjchem-1346	366	3	)	)	PUNCT
eurjchem-1346	366	4	3d	3d	NUM
eurjchem-1346	366	5	protonation	protonation	NOUN
eurjchem-1346	366	6	for	for	ADP
eurjchem-1346	366	7	the	the	DET
eurjchem-1346	366	8	amino	amino	NOUN
eurjchem-1346	366	9	acid	acid	NOUN
eurjchem-1346	366	10	side	side	NOUN
eurjchem-1346	366	11	chain	chain	NOUN
eurjchem-1346	366	12	and	and	CCONJ
eurjchem-1346	366	13	ligand	ligand	NOUN
eurjchem-1346	366	14	.	.	PUNCT
eurjchem-1346	367	1	(	(	PUNCT
eurjchem-1346	367	2	ii	ii	NOUN
eurjchem-1346	367	3	)	)	PUNCT
eurjchem-1346	367	4	deleting	delete	VERB
eurjchem-1346	367	5	all	all	DET
eurjchem-1346	367	6	water	water	NOUN
eurjchem-1346	367	7	of	of	ADP
eurjchem-1346	367	8	crystallization	crystallization	NOUN
eurjchem-1346	367	9	away	away	ADV
eurjchem-1346	367	10	from	from	ADP
eurjchem-1346	367	11	the	the	DET
eurjchem-1346	367	12	active	active	ADJ
eurjchem-1346	367	13	site	site	NOUN
eurjchem-1346	367	14	.	.	PUNCT
eurjchem-1346	368	1	(	(	PUNCT
eurjchem-1346	368	2	iii	iii	X
eurjchem-1346	368	3	)	)	PUNCT
eurjchem-1346	368	4	isolation	isolation	NOUN
eurjchem-1346	368	5	of	of	ADP
eurjchem-1346	368	6	the	the	DET
eurjchem-1346	368	7	active	active	ADJ
eurjchem-1346	368	8	site	site	NOUN
eurjchem-1346	368	9	,	,	PUNCT
eurjchem-1346	368	10	fixation	fixation	NOUN
eurjchem-1346	368	11	to	to	PART
eurjchem-1346	368	12	be	be	AUX
eurjchem-1346	368	13	dealt	deal	VERB
eurjchem-1346	368	14	with	with	ADP
eurjchem-1346	368	15	as	as	ADP
eurjchem-1346	368	16	rigid	rigid	ADJ
eurjchem-1346	368	17	structure	structure	NOUN
eurjchem-1346	368	18	and	and	CCONJ
eurjchem-1346	368	19	recognition	recognition	NOUN
eurjchem-1346	368	20	of	of	ADP
eurjchem-1346	368	21	the	the	DET
eurjchem-1346	368	22	amino	amino	NOUN
eurjchem-1346	368	23	acids	acid	NOUN
eurjchem-1346	368	24	.	.	PUNCT
eurjchem-1346	369	1	(	(	PUNCT
eurjchem-1346	369	2	iv	iv	X
eurjchem-1346	369	3	)	)	PUNCT
eurjchem-1346	369	4	creation	creation	NOUN
eurjchem-1346	369	5	of	of	ADP
eurjchem-1346	369	6	dummies	dummy	NOUN
eurjchem-1346	369	7	around	around	ADP
eurjchem-1346	369	8	the	the	DET
eurjchem-1346	369	9	active	active	ADJ
eurjchem-1346	369	10	site	site	NOUN
eurjchem-1346	369	11	.	.	PUNCT
eurjchem-1346	370	1	(	(	PUNCT
eurjchem-1346	370	2	v	v	NOUN
eurjchem-1346	370	3	)	)	PUNCT
eurjchem-1346	370	4	studying	study	VERB
eurjchem-1346	370	5	the	the	DET
eurjchem-1346	370	6	interactions	interaction	NOUN
eurjchem-1346	370	7	of	of	ADP
eurjchem-1346	370	8	the	the	DET
eurjchem-1346	370	9	ligand	ligand	NOUN
eurjchem-1346	370	10	with	with	ADP
eurjchem-1346	370	11	the	the	DET
eurjchem-1346	370	12	amino	amino	ADJ
eurjchem-1346	370	13	acids	acid	NOUN
eurjchem-1346	370	14	of	of	ADP
eurjchem-1346	370	15	the	the	DET
eurjchem-1346	370	16	active	active	ADJ
eurjchem-1346	370	17	site	site	NOUN
eurjchem-1346	370	18	.	.	PUNCT
eurjchem-1346	371	1	2.3.3	2.3.3	X
eurjchem-1346	371	2	.	.	PUNCT
eurjchem-1346	371	3	preparation	preparation	NOUN
eurjchem-1346	371	4	of	of	ADP
eurjchem-1346	371	5	compounds	compound	NOUN
eurjchem-1346	371	6	for	for	ADP
eurjchem-1346	371	7	docking	dock	VERB
eurjchem-1346	371	8	the	the	DET
eurjchem-1346	371	9	3d	3d	NUM
eurjchem-1346	371	10	structures	structure	NOUN
eurjchem-1346	371	11	of	of	ADP
eurjchem-1346	371	12	the	the	DET
eurjchem-1346	371	13	synthesized	synthesize	VERB
eurjchem-1346	371	14	compounds	compound	NOUN
eurjchem-1346	371	15	in	in	ADP
eurjchem-1346	371	16	addition	addition	NOUN
eurjchem-1346	371	17	to	to	ADP
eurjchem-1346	371	18	sorafenib	sorafenib	PROPN
eurjchem-1346	371	19	(	(	PUNCT
eurjchem-1346	371	20	standard	standard	NOUN
eurjchem-1346	371	21	used	use	VERB
eurjchem-1346	371	22	for	for	ADP
eurjchem-1346	371	23	enzyme	enzyme	NOUN
eurjchem-1346	371	24	inhibition	inhibition	NOUN
eurjchem-1346	371	25	assay	assay	NOUN
eurjchem-1346	371	26	)	)	PUNCT
eurjchem-1346	371	27	were	be	AUX
eurjchem-1346	371	28	built	build	VERB
eurjchem-1346	371	29	using	use	VERB
eurjchem-1346	371	30	moe	moe	NOUN
eurjchem-1346	371	31	and	and	CCONJ
eurjchem-1346	371	32	subjected	subject	VERB
eurjchem-1346	371	33	to	to	ADP
eurjchem-1346	371	34	the	the	DET
eurjchem-1346	371	35	following	follow	VERB
eurjchem-1346	371	36	procedure	procedure	NOUN
eurjchem-1346	371	37	:	:	PUNCT
eurjchem-1346	371	38	(	(	PUNCT
eurjchem-1346	371	39	i	i	NOUN
eurjchem-1346	371	40	)	)	PUNCT
eurjchem-1346	371	41	3d	3d	NUM
eurjchem-1346	371	42	protonation	protonation	NOUN
eurjchem-1346	371	43	of	of	ADP
eurjchem-1346	371	44	the	the	DET
eurjchem-1346	371	45	structures	structure	NOUN
eurjchem-1346	371	46	.	.	PUNCT
eurjchem-1346	372	1	(	(	PUNCT
eurjchem-1346	372	2	ii	ii	NOUN
eurjchem-1346	372	3	)	)	PUNCT
eurjchem-1346	372	4	running	run	VERB
eurjchem-1346	372	5	conformational	conformational	ADJ
eurjchem-1346	372	6	analysis	analysis	NOUN
eurjchem-1346	372	7	using	use	VERB
eurjchem-1346	372	8	systemic	systemic	ADJ
eurjchem-1346	372	9	search	search	NOUN
eurjchem-1346	372	10	.	.	PUNCT
eurjchem-1346	373	1	(	(	PUNCT
eurjchem-1346	373	2	iii	iii	X
eurjchem-1346	373	3	)	)	PUNCT
eurjchem-1346	373	4	selecting	select	VERB
eurjchem-1346	373	5	the	the	DET
eurjchem-1346	373	6	least	least	ADV
eurjchem-1346	373	7	energetic	energetic	ADJ
eurjchem-1346	373	8	conformer	conformer	NOUN
eurjchem-1346	373	9	.	.	PUNCT
eurjchem-1346	374	1	(	(	PUNCT
eurjchem-1346	374	2	iv	iv	X
eurjchem-1346	374	3	)	)	PUNCT
eurjchem-1346	374	4	applying	apply	VERB
eurjchem-1346	374	5	the	the	DET
eurjchem-1346	374	6	same	same	ADJ
eurjchem-1346	374	7	docking	docking	NOUN
eurjchem-1346	374	8	protocol	protocol	NOUN
eurjchem-1346	374	9	used	use	VERB
eurjchem-1346	374	10	with	with	ADP
eurjchem-1346	374	11	ligand	ligand	NOUN
eurjchem-1346	374	12	2.3.4	2.3.4	NUM
eurjchem-1346	374	13	.	.	PUNCT
eurjchem-1346	375	1	docking	dock	VERB
eurjchem-1346	375	2	running	run	VERB
eurjchem-1346	375	3	prior	prior	ADV
eurjchem-1346	375	4	to	to	ADP
eurjchem-1346	375	5	the	the	DET
eurjchem-1346	375	6	docking	docking	NOUN
eurjchem-1346	375	7	of	of	ADP
eurjchem-1346	375	8	the	the	DET
eurjchem-1346	375	9	pyridopyrazinone	pyridopyrazinone	NOUN
eurjchem-1346	375	10	derivatives	derivative	NOUN
eurjchem-1346	375	11	,	,	PUNCT
eurjchem-1346	375	12	redocking	redocke	VERB
eurjchem-1346	375	13	of	of	ADP
eurjchem-1346	375	14	the	the	DET
eurjchem-1346	375	15	plx3203	plx3203	NOUN
eurjchem-1346	375	16	bound	bind	VERB
eurjchem-1346	375	17	in	in	ADP
eurjchem-1346	375	18	the	the	DET
eurjchem-1346	375	19	v600ebraf	v600ebraf	NOUN
eurjchem-1346	375	20	active	active	ADJ
eurjchem-1346	375	21	site	site	NOUN
eurjchem-1346	375	22	was	be	AUX
eurjchem-1346	375	23	performed	perform	VERB
eurjchem-1346	375	24	to	to	PART
eurjchem-1346	375	25	validate	validate	VERB
eurjchem-1346	375	26	the	the	DET
eurjchem-1346	375	27	docking	docking	NOUN
eurjchem-1346	375	28	protocol	protocol	NOUN
eurjchem-1346	375	29	.	.	PUNCT
eurjchem-1346	376	1	the	the	DET
eurjchem-1346	376	2	generated	generate	VERB
eurjchem-1346	376	3	most	most	ADV
eurjchem-1346	376	4	stable	stable	ADJ
eurjchem-1346	376	5	conformer	conformer	NOUN
eurjchem-1346	376	6	of	of	ADP
eurjchem-1346	376	7	each	each	DET
eurjchem-1346	376	8	compound	compound	NOUN
eurjchem-1346	376	9	was	be	AUX
eurjchem-1346	376	10	virtually	virtually	ADV
eurjchem-1346	376	11	docked	dock	VERB
eurjchem-1346	376	12	into	into	ADP
eurjchem-1346	376	13	the	the	DET
eurjchem-1346	376	14	predefined	predefine	VERB
eurjchem-1346	376	15	active	active	ADJ
eurjchem-1346	376	16	site	site	NOUN
eurjchem-1346	376	17	of	of	ADP
eurjchem-1346	376	18	v600ebraf	v600ebraf	PROPN
eurjchem-1346	376	19	.	.	PUNCT
eurjchem-1346	377	1	the	the	DET
eurjchem-1346	377	2	developed	develop	VERB
eurjchem-1346	377	3	docked	docked	ADJ
eurjchem-1346	377	4	models	model	NOUN
eurjchem-1346	377	5	were	be	AUX
eurjchem-1346	377	6	energetically	energetically	ADV
eurjchem-1346	377	7	minimized	minimize	VERB
eurjchem-1346	377	8	and	and	CCONJ
eurjchem-1346	377	9	then	then	ADV
eurjchem-1346	377	10	used	use	VERB
eurjchem-1346	377	11	to	to	PART
eurjchem-1346	377	12	predict	predict	VERB
eurjchem-1346	377	13	the	the	DET
eurjchem-1346	377	14	interaction	interaction	NOUN
eurjchem-1346	377	15	of	of	ADP
eurjchem-1346	377	16	the	the	DET
eurjchem-1346	377	17	ligand	ligand	NOUN
eurjchem-1346	377	18	with	with	ADP
eurjchem-1346	377	19	the	the	DET
eurjchem-1346	377	20	amino	amino	NOUN
eurjchem-1346	377	21	acids	acid	NOUN
eurjchem-1346	377	22	in	in	ADP
eurjchem-1346	377	23	the	the	DET
eurjchem-1346	377	24	active	active	ADJ
eurjchem-1346	377	25	site	site	NOUN
eurjchem-1346	377	26	of	of	ADP
eurjchem-1346	377	27	the	the	DET
eurjchem-1346	377	28	enzyme	enzyme	NOUN
eurjchem-1346	377	29	.	.	PUNCT
eurjchem-1346	378	1	3	3	X
eurjchem-1346	378	2	.	.	NOUN
eurjchem-1346	378	3	results	result	NOUN
eurjchem-1346	378	4	and	and	CCONJ
eurjchem-1346	378	5	discussion	discussion	NOUN
eurjchem-1346	378	6	3.1	3.1	NUM
eurjchem-1346	378	7	.	.	PUNCT
eurjchem-1346	379	1	chemistry	chemistry	NOUN
eurjchem-1346	379	2	the	the	DET
eurjchem-1346	379	3	target	target	NOUN
eurjchem-1346	379	4	compounds	compound	VERB
eurjchem-1346	379	5	1	1	NUM
eurjchem-1346	379	6	,	,	PUNCT
eurjchem-1346	379	7	2	2	NUM
eurjchem-1346	379	8	,	,	PUNCT
eurjchem-1346	379	9	3a‐j	3a‐j	NOUN
eurjchem-1346	379	10	,	,	PUNCT
eurjchem-1346	379	11	4	4	NUM
eurjchem-1346	379	12	,	,	PUNCT
eurjchem-1346	379	13	5a‐e	5a‐e	NUM
eurjchem-1346	379	14	,	,	PUNCT
eurjchem-1346	379	15	6a‐d	6a‐d	NOUN
eurjchem-1346	379	16	,	,	PUNCT
eurjchem-1346	379	17	and	and	CCONJ
eurjchem-1346	379	18	7a‐c	7a‐c	NOUN
eurjchem-1346	379	19	were	be	AUX
eurjchem-1346	379	20	synthesized	synthesize	VERB
eurjchem-1346	379	21	as	as	SCONJ
eurjchem-1346	379	22	depicted	depict	VERB
eurjchem-1346	379	23	in	in	ADP
eurjchem-1346	379	24	scheme	scheme	NOUN
eurjchem-1346	379	25	1	1	NUM
eurjchem-1346	379	26	.	.	PUNCT
eurjchem-1346	379	27	condensation	condensation	NOUN
eurjchem-1346	379	28	of	of	ADP
eurjchem-1346	379	29	2,3‐diaminopyridine	2,3‐diaminopyridine	NUM
eurjchem-1346	379	30	with	with	ADP
eurjchem-1346	379	31	ethyl	ethyl	PROPN
eurjchem-1346	379	32	pyruvate	pyruvate	NOUN
eurjchem-1346	379	33	in	in	ADP
eurjchem-1346	379	34	ethanol	ethanol	NOUN
eurjchem-1346	379	35	provided	provide	VERB
eurjchem-1346	379	36	methylpyridopyrazinone	methylpyridopyrazinone	NOUN
eurjchem-1346	379	37	,	,	PUNCT
eurjchem-1346	379	38	1	1	NUM
eurjchem-1346	379	39	.	.	X
eurjchem-1346	380	1	ir	ir	PROPN
eurjchem-1346	380	2	spectrum	spectrum	PROPN
eurjchem-1346	380	3	showed	show	VERB
eurjchem-1346	380	4	a	a	DET
eurjchem-1346	380	5	band	band	NOUN
eurjchem-1346	380	6	at	at	ADP
eurjchem-1346	380	7	3186	3186	NUM
eurjchem-1346	380	8	cm‐1	cm‐1	NOUN
eurjchem-1346	380	9	assigned	assign	VERB
eurjchem-1346	380	10	to	to	ADP
eurjchem-1346	380	11	nh	nh	PROPN
eurjchem-1346	380	12	group	group	NOUN
eurjchem-1346	380	13	and	and	CCONJ
eurjchem-1346	380	14	a	a	DET
eurjchem-1346	380	15	band	band	NOUN
eurjchem-1346	380	16	at	at	ADP
eurjchem-1346	380	17	1685	1685	NUM
eurjchem-1346	380	18	cm‐	cm‐	PROPN
eurjchem-1346	381	1	1attributed	1attribute	VERB
eurjchem-1346	381	2	to	to	ADP
eurjchem-1346	381	3	c	c	NOUN
eurjchem-1346	381	4	=	=	NOUN
eurjchem-1346	381	5	o	o	NOUN
eurjchem-1346	381	6	group	group	NOUN
eurjchem-1346	381	7	.	.	PUNCT
eurjchem-1346	382	1	1h	1h	NUM
eurjchem-1346	382	2	nmr	nmr	NOUN
eurjchem-1346	382	3	showed	show	VERB
eurjchem-1346	382	4	a	a	DET
eurjchem-1346	382	5	singlet	singlet	ADJ
eurjchem-1346	382	6	peak	peak	NOUN
eurjchem-1346	382	7	at	at	ADP
eurjchem-1346	382	8	δ	δ	PROPN
eurjchem-1346	382	9	2.41	2.41	NUM
eurjchem-1346	382	10	ppm	ppm	NOUN
eurjchem-1346	382	11	assigned	assign	VERB
eurjchem-1346	382	12	to	to	ADP
eurjchem-1346	382	13	ch3	ch3	PROPN
eurjchem-1346	382	14	protons	proton	NOUN
eurjchem-1346	382	15	in	in	ADP
eurjchem-1346	382	16	addition	addition	NOUN
eurjchem-1346	382	17	to	to	ADP
eurjchem-1346	382	18	doublet	doublet	ADJ
eurjchem-1346	382	19	,	,	PUNCT
eurjchem-1346	382	20	triplet	triplet	NOUN
eurjchem-1346	382	21	and	and	CCONJ
eurjchem-1346	382	22	doublet	doublet	NOUN
eurjchem-1346	382	23	at	at	ADP
eurjchem-1346	382	24	δ7.48	δ7.48	PROPN
eurjchem-1346	382	25	,	,	PUNCT
eurjchem-1346	382	26	7.67	7.67	NUM
eurjchem-1346	382	27	,	,	PUNCT
eurjchem-1346	382	28	8.11	8.11	NUM
eurjchem-1346	382	29	ppm	ppm	NOUN
eurjchem-1346	382	30	,	,	PUNCT
eurjchem-1346	382	31	respectively	respectively	ADV
eurjchem-1346	382	32	,	,	PUNCT
eurjchem-1346	382	33	corresponding	correspond	VERB
eurjchem-1346	382	34	to	to	ADP
eurjchem-1346	382	35	pyridine	pyridine	ADJ
eurjchem-1346	382	36	protons	proton	NOUN
eurjchem-1346	382	37	.	.	PUNCT
eurjchem-1346	383	1	bromomethyl	bromomethyl	PROPN
eurjchem-1346	383	2	compound	compound	PROPN
eurjchem-1346	383	3	2	2	NUM
eurjchem-1346	383	4	was	be	AUX
eurjchem-1346	383	5	achieved	achieve	VERB
eurjchem-1346	383	6	via	via	ADP
eurjchem-1346	383	7	bromination	bromination	NOUN
eurjchem-1346	383	8	of	of	ADP
eurjchem-1346	383	9	compound	compound	NOUN
eurjchem-1346	383	10	1	1	NUM
eurjchem-1346	383	11	with	with	ADP
eurjchem-1346	383	12	bromine	bromine	NOUN
eurjchem-1346	383	13	.	.	PUNCT
eurjchem-1346	384	1	use	use	NOUN
eurjchem-1346	384	2	of	of	ADP
eurjchem-1346	384	3	bromine	bromine	NOUN
eurjchem-1346	384	4	in	in	ADP
eurjchem-1346	384	5	presence	presence	NOUN
eurjchem-1346	384	6	of	of	ADP
eurjchem-1346	384	7	sodium	sodium	NOUN
eurjchem-1346	384	8	acetate	acetate	NOUN
eurjchem-1346	384	9	in	in	ADP
eurjchem-1346	384	10	glacial	glacial	ADJ
eurjchem-1346	384	11	acetic	acetic	ADJ
eurjchem-1346	384	12	acid	acid	NOUN
eurjchem-1346	384	13	gave	give	VERB
eurjchem-1346	384	14	higher	high	ADJ
eurjchem-1346	384	15	yield	yield	NOUN
eurjchem-1346	384	16	than	than	ADP
eurjchem-1346	384	17	bromination	bromination	NOUN
eurjchem-1346	384	18	with	with	ADP
eurjchem-1346	384	19	n‐bromo‐	n‐bromo‐	NOUN
eurjchem-1346	384	20	succinamide	succinamide	NOUN
eurjchem-1346	384	21	[	[	X
eurjchem-1346	384	22	29	29	NUM
eurjchem-1346	384	23	]	]	PUNCT
eurjchem-1346	384	24	.	.	PUNCT
eurjchem-1346	385	1	1h	1h	NUM
eurjchem-1346	385	2	nmr	nmr	PROPN
eurjchem-1346	385	3	spectrum	spectrum	NOUN
eurjchem-1346	385	4	revealed	reveal	VERB
eurjchem-1346	385	5	disappearance	disappearance	NOUN
eurjchem-1346	385	6	of	of	ADP
eurjchem-1346	385	7	methyl	methyl	NOUN
eurjchem-1346	385	8	protons	proton	NOUN
eurjchem-1346	385	9	singlet	singlet	NOUN
eurjchem-1346	385	10	peak	peak	NOUN
eurjchem-1346	385	11	at	at	ADP
eurjchem-1346	385	12	δ	δ	PROPN
eurjchem-1346	385	13	2.41	2.41	NUM
eurjchem-1346	385	14	ppm	ppm	NOUN
eurjchem-1346	385	15	and	and	CCONJ
eurjchem-1346	385	16	appearance	appearance	NOUN
eurjchem-1346	385	17	of	of	ADP
eurjchem-1346	385	18	singlet	singlet	ADJ
eurjchem-1346	385	19	peak	peak	NOUN
eurjchem-1346	385	20	at	at	ADP
eurjchem-1346	385	21	δ	δ	PROPN
eurjchem-1346	385	22	3.10	3.10	NUM
eurjchem-1346	385	23	ppm	ppm	NOUN
eurjchem-1346	385	24	assigned	assign	VERB
eurjchem-1346	385	25	to	to	ADP
eurjchem-1346	385	26	ch2	ch2	NOUN
eurjchem-1346	385	27	protons	proton	NOUN
eurjchem-1346	385	28	.	.	PUNCT
eurjchem-1346	386	1	mass	mass	PROPN
eurjchem-1346	386	2	spectrum	spectrum	PROPN
eurjchem-1346	386	3	showed	show	VERB
eurjchem-1346	386	4	both	both	DET
eurjchem-1346	386	5	m+	m+	NOUN
eurjchem-1346	386	6	and	and	CCONJ
eurjchem-1346	386	7	m++2	m++2	NUM
eurjchem-1346	386	8	at	at	ADP
eurjchem-1346	386	9	240	240	NUM
eurjchem-1346	386	10	and	and	CCONJ
eurjchem-1346	386	11	242	242	NUM
eurjchem-1346	386	12	m	m	PROPN
eurjchem-1346	386	13	/	/	SYM
eurjchem-1346	386	14	z	z	NOUN
eurjchem-1346	386	15	,	,	PUNCT
eurjchem-1346	386	16	respectively	respectively	ADV
eurjchem-1346	386	17	.	.	PUNCT
eurjchem-1346	387	1	refluxing	refluxing	PROPN
eurjchem-1346	387	2	bromomethyl	bromomethyl	PROPN
eurjchem-1346	387	3	compound	compound	PROPN
eurjchem-1346	387	4	2	2	NUM
eurjchem-1346	387	5	with	with	ADP
eurjchem-1346	387	6	different	different	ADJ
eurjchem-1346	387	7	primary	primary	ADJ
eurjchem-1346	387	8	or	or	CCONJ
eurjchem-1346	387	9	secondary	secondary	ADJ
eurjchem-1346	387	10	amines	amine	NOUN
eurjchem-1346	387	11	in	in	ADP
eurjchem-1346	387	12	ethanol	ethanol	NOUN
eurjchem-1346	387	13	afforded	afford	VERB
eurjchem-1346	387	14	compounds	compound	NOUN
eurjchem-1346	387	15	3a‐j	3a‐j	PROPN
eurjchem-1346	387	16	.	.	PUNCT
eurjchem-1346	388	1	catalytic	catalytic	ADJ
eurjchem-1346	388	2	amount	amount	NOUN
eurjchem-1346	388	3	of	of	ADP
eurjchem-1346	388	4	sodium	sodium	NOUN
eurjchem-1346	388	5	iodide	iodide	NOUN
eurjchem-1346	388	6	was	be	AUX
eurjchem-1346	388	7	used	use	VERB
eurjchem-1346	388	8	to	to	PART
eurjchem-1346	388	9	accelerate	accelerate	VERB
eurjchem-1346	388	10	the	the	DET
eurjchem-1346	388	11	reaction	reaction	NOUN
eurjchem-1346	388	12	[	[	X
eurjchem-1346	388	13	30	30	NUM
eurjchem-1346	388	14	]	]	PUNCT
eurjchem-1346	388	15	.	.	PUNCT
eurjchem-1346	389	1	ir	ir	PROPN
eurjchem-1346	389	2	spectra	spectra	PROPN
eurjchem-1346	389	3	showed	show	VERB
eurjchem-1346	389	4	a	a	DET
eurjchem-1346	389	5	band	band	NOUN
eurjchem-1346	389	6	at	at	ADP
eurjchem-1346	389	7	3421‐3350	3421‐3350	PROPN
eurjchem-1346	389	8	cm‐1	cm‐1	PROPN
eurjchem-1346	389	9	corresponding	correspond	VERB
eurjchem-1346	389	10	to	to	ADP
eurjchem-1346	389	11	additional	additional	ADJ
eurjchem-1346	389	12	nh	nh	PROPN
eurjchem-1346	389	13	group	group	NOUN
eurjchem-1346	389	14	for	for	ADP
eurjchem-1346	389	15	compounds	compound	NOUN
eurjchem-1346	389	16	3d‐i	3d‐i	PROPN
eurjchem-1346	389	17	.	.	PUNCT
eurjchem-1346	390	1	in	in	ADP
eurjchem-1346	390	2	addition	addition	NOUN
eurjchem-1346	390	3	,	,	PUNCT
eurjchem-1346	390	4	1h	1h	NUM
eurjchem-1346	390	5	nmr	nmr	NOUN
eurjchem-1346	390	6	spectra	spectra	NOUN
eurjchem-1346	390	7	showed	show	VERB
eurjchem-1346	390	8	added	add	VERB
eurjchem-1346	390	9	aliphatic	aliphatic	ADJ
eurjchem-1346	390	10	protons	proton	NOUN
eurjchem-1346	390	11	at	at	ADP
eurjchem-1346	390	12	δ	δ	PROPN
eurjchem-1346	390	13	1.41‐3.30	1.41‐3.30	PROPN
eurjchem-1346	390	14	ppm	ppm	NOUN
eurjchem-1346	390	15	for	for	ADP
eurjchem-1346	390	16	compounds	compound	NOUN
eurjchem-1346	390	17	3a‐c	3a‐c	PROPN
eurjchem-1346	390	18	or	or	CCONJ
eurjchem-1346	390	19	additional	additional	ADJ
eurjchem-1346	390	20	aromatic	aromatic	ADJ
eurjchem-1346	390	21	protons	proton	NOUN
eurjchem-1346	390	22	at	at	ADP
eurjchem-1346	390	23	δ	δ	PROPN
eurjchem-1346	390	24	6.12‐7.20	6.12‐7.20	NUM
eurjchem-1346	390	25	ppm	ppm	VERB
eurjchem-1346	390	26	for	for	ADP
eurjchem-1346	390	27	compounds	compound	NOUN
eurjchem-1346	390	28	3d‐j	3d‐j	NOUN
eurjchem-1346	390	29	and	and	CCONJ
eurjchem-1346	390	30	additional	additional	ADJ
eurjchem-1346	390	31	singlet	singlet	NOUN
eurjchem-1346	390	32	peak	peak	NOUN
eurjchem-1346	390	33	at	at	ADP
eurjchem-1346	390	34	δ	δ	PROPN
eurjchem-1346	390	35	10.09‐11.61	10.09‐11.61	NUM
eurjchem-1346	390	36	ppm	ppm	NOUN
eurjchem-1346	390	37	exchanged	exchange	VERB
eurjchem-1346	390	38	with	with	ADP
eurjchem-1346	390	39	d2o	d2o	PROPN
eurjchem-1346	390	40	corresponding	correspond	VERB
eurjchem-1346	390	41	to	to	ADP
eurjchem-1346	390	42	nh	nh	PROPN
eurjchem-1346	390	43	proton	proton	NOUN
eurjchem-1346	390	44	for	for	ADP
eurjchem-1346	390	45	compounds	compound	NOUN
eurjchem-1346	390	46	3d‐i	3d‐i	PROPN
eurjchem-1346	390	47	.	.	PUNCT
eurjchem-1346	391	1	refluxing	refluxing	PROPN
eurjchem-1346	391	2	bromomethyl	bromomethyl	PROPN
eurjchem-1346	391	3	compound	compound	PROPN
eurjchem-1346	391	4	2	2	NUM
eurjchem-1346	391	5	with	with	ADP
eurjchem-1346	391	6	hydrazine	hydrazine	NOUN
eurjchem-1346	391	7	hydrate	hydrate	NOUN
eurjchem-1346	391	8	in	in	ADP
eurjchem-1346	391	9	ethanol	ethanol	NOUN
eurjchem-1346	391	10	afforded	afford	VERB
eurjchem-1346	391	11	compound	compound	NOUN
eurjchem-1346	391	12	4	4	NUM
eurjchem-1346	391	13	.	.	NOUN
eurjchem-1346	391	14	1h	1h	NUM
eurjchem-1346	391	15	nmr	nmr	NOUN
eurjchem-1346	391	16	spectrum	spectrum	NOUN
eurjchem-1346	391	17	showed	show	VERB
eurjchem-1346	391	18	additional	additional	ADJ
eurjchem-1346	391	19	two	two	NUM
eurjchem-1346	391	20	singlet	singlet	ADJ
eurjchem-1346	391	21	peaks	peak	NOUN
eurjchem-1346	391	22	at	at	ADP
eurjchem-1346	391	23	δ	δ	PROPN
eurjchem-1346	391	24	10.72	10.72	NUM
eurjchem-1346	391	25	and	and	CCONJ
eurjchem-1346	391	26	11.22	11.22	NUM
eurjchem-1346	391	27	ppm	ppm	NOUN
eurjchem-1346	391	28	exchanged	exchange	VERB
eurjchem-1346	391	29	with	with	ADP
eurjchem-1346	391	30	d2o	d2o	PROPN
eurjchem-1346	391	31	corresponding	correspond	VERB
eurjchem-1346	391	32	to	to	ADP
eurjchem-1346	391	33	added	add	VERB
eurjchem-1346	391	34	nh	nh	PROPN
eurjchem-1346	391	35	and	and	CCONJ
eurjchem-1346	391	36	nh2	nh2	PROPN
eurjchem-1346	391	37	protons	proton	NOUN
eurjchem-1346	391	38	,	,	PUNCT
eurjchem-1346	391	39	respectively	respectively	ADV
eurjchem-1346	391	40	.	.	PUNCT
eurjchem-1346	392	1	compounds	compound	VERB
eurjchem-1346	392	2	5a‐e	5a‐e	PROPN
eurjchem-1346	392	3	were	be	AUX
eurjchem-1346	392	4	prepared	prepare	VERB
eurjchem-1346	392	5	via	via	ADP
eurjchem-1346	392	6	reaction	reaction	NOUN
eurjchem-1346	392	7	of	of	ADP
eurjchem-1346	392	8	hydrazino	hydrazino	NOUN
eurjchem-1346	392	9	compound	compound	NOUN
eurjchem-1346	392	10	4	4	NUM
eurjchem-1346	392	11	with	with	ADP
eurjchem-1346	392	12	different	different	ADJ
eurjchem-1346	392	13	appropriate	appropriate	ADJ
eurjchem-1346	392	14	aldehyde	aldehyde	NOUN
eurjchem-1346	392	15	or	or	CCONJ
eurjchem-1346	392	16	ketone	ketone	NOUN
eurjchem-1346	392	17	in	in	ADP
eurjchem-1346	392	18	glacial	glacial	ADJ
eurjchem-1346	392	19	acetic	acetic	ADJ
eurjchem-1346	392	20	acid	acid	NOUN
eurjchem-1346	392	21	.	.	PUNCT
eurjchem-1346	393	1	1h	1h	NUM
eurjchem-1346	393	2	nmr	nmr	PROPN
eurjchem-1346	393	3	spectra	spectra	NOUN
eurjchem-1346	393	4	showed	show	VERB
eurjchem-1346	393	5	additional	additional	ADJ
eurjchem-1346	393	6	aromatic	aromatic	ADJ
eurjchem-1346	393	7	protons	proton	NOUN
eurjchem-1346	393	8	at	at	ADP
eurjchem-1346	393	9	δ	δ	PROPN
eurjchem-1346	393	10	6.76‐8.10	6.76‐8.10	NUM
eurjchem-1346	393	11	ppm	ppm	NOUN
eurjchem-1346	393	12	in	in	ADP
eurjchem-1346	393	13	addition	addition	NOUN
eurjchem-1346	393	14	to	to	PART
eurjchem-1346	393	15	signal	signal	VERB
eurjchem-1346	393	16	at	at	ADP
eurjchem-1346	393	17	δ	δ	PROPN
eurjchem-1346	393	18	8.10‐8.19	8.10‐8.19	NUM
eurjchem-1346	393	19	ppm	ppm	NOUN
eurjchem-1346	393	20	corresponding	correspond	VERB
eurjchem-1346	393	21	to	to	ADP
eurjchem-1346	393	22	benzylidene	benzylidene	NOUN
eurjchem-1346	393	23	proton	proton	NOUN
eurjchem-1346	393	24	for	for	ADP
eurjchem-1346	393	25	compounds	compound	NOUN
eurjchem-1346	393	26	5a‐d	5a‐d	ADV
eurjchem-1346	393	27	.	.	PUNCT
eurjchem-1346	394	1	adopting	adopt	VERB
eurjchem-1346	394	2	cyclization	cyclization	NOUN
eurjchem-1346	394	3	with	with	ADP
eurjchem-1346	394	4	the	the	DET
eurjchem-1346	394	5	aid	aid	NOUN
eurjchem-1346	394	6	of	of	ADP
eurjchem-1346	394	7	bromine	bromine	NOUN
eurjchem-1346	394	8	and	and	CCONJ
eurjchem-1346	394	9	sodium	sodium	NOUN
eurjchem-1346	394	10	acetate	acetate	NOUN
eurjchem-1346	394	11	in	in	ADP
eurjchem-1346	394	12	glacial	glacial	ADJ
eurjchem-1346	394	13	acetic	acetic	ADJ
eurjchem-1346	394	14	acid	acid	NOUN
eurjchem-1346	394	15	at	at	ADP
eurjchem-1346	394	16	room	room	NOUN
eurjchem-1346	394	17	temperature	temperature	NOUN
eurjchem-1346	395	1	[	[	X
eurjchem-1346	395	2	31,32	31,32	NUM
eurjchem-1346	395	3	]	]	PUNCT
eurjchem-1346	395	4	for	for	ADP
eurjchem-1346	395	5	compounds	compound	NOUN
eurjchem-1346	395	6	5a‐d	5a‐d	ADP
eurjchem-1346	395	7	afforded	afford	VERB
eurjchem-1346	395	8	compounds	compound	NOUN
eurjchem-1346	395	9	6a‐d	6a‐d	NOUN
eurjchem-1346	395	10	.	.	PUNCT
eurjchem-1346	396	1	1h	1h	NUM
eurjchem-1346	396	2	nmr	nmr	PROPN
eurjchem-1346	396	3	spectra	spectra	NOUN
eurjchem-1346	396	4	showed	show	VERB
eurjchem-1346	396	5	additional	additional	ADJ
eurjchem-1346	396	6	singlet	singlet	NOUN
eurjchem-1346	396	7	signal	signal	NOUN
eurjchem-1346	396	8	at	at	ADP
eurjchem-1346	396	9	δ	δ	PROPN
eurjchem-1346	396	10	5.82‐6.21	5.82‐6.21	NUM
eurjchem-1346	396	11	ppm	ppm	NUM
eurjchem-1346	396	12	corresponding	correspond	VERB
eurjchem-1346	396	13	triazine	triazine	NOUN
eurjchem-1346	396	14	proton	proton	NOUN
eurjchem-1346	396	15	.	.	PUNCT
eurjchem-1346	397	1	refluxing	refluxing	NOUN
eurjchem-1346	397	2	compound	compound	NOUN
eurjchem-1346	397	3	4	4	NUM
eurjchem-1346	397	4	with	with	ADP
eurjchem-1346	397	5	different	different	ADJ
eurjchem-1346	397	6	cyclic	cyclic	ADJ
eurjchem-1346	397	7	acid	acid	NOUN
eurjchem-1346	397	8	anhydrides	anhydride	NOUN
eurjchem-1346	397	9	in	in	ADP
eurjchem-1346	397	10	glacial	glacial	ADJ
eurjchem-1346	397	11	acetic	acetic	ADJ
eurjchem-1346	397	12	acid	acid	NOUN
eurjchem-1346	397	13	provided	provide	VERB
eurjchem-1346	397	14	compounds	compound	NOUN
eurjchem-1346	397	15	7a‐c	7a‐c	NOUN
eurjchem-1346	397	16	.	.	PUNCT
eurjchem-1346	398	1	1h	1h	NUM
eurjchem-1346	398	2	nmr	nmr	PROPN
eurjchem-1346	398	3	spectra	spectra	NOUN
eurjchem-1346	398	4	showed	show	VERB
eurjchem-1346	398	5	additional	additional	ADJ
eurjchem-1346	398	6	triplet	triplet	NOUN
eurjchem-1346	398	7	signal	signal	NOUN
eurjchem-1346	398	8	at	at	ADP
eurjchem-1346	398	9	δ	δ	PROPN
eurjchem-1346	398	10	3.11	3.11	NUM
eurjchem-1346	398	11	ppm	ppm	NOUN
eurjchem-1346	398	12	assigned	assign	VERB
eurjchem-1346	398	13	to	to	ADP
eurjchem-1346	398	14	ch2‐ch2	ch2‐ch2	ADJ
eurjchem-1346	398	15	protons	proton	NOUN
eurjchem-1346	398	16	for	for	ADP
eurjchem-1346	398	17	compound	compound	NOUN
eurjchem-1346	398	18	7a	7a	NOUN
eurjchem-1346	398	19	or	or	CCONJ
eurjchem-1346	398	20	a	a	DET
eurjchem-1346	398	21	doublet	doublet	ADJ
eurjchem-1346	398	22	signal	signal	NOUN
eurjchem-1346	398	23	at	at	ADP
eurjchem-1346	398	24	δ	δ	PROPN
eurjchem-1346	398	25	5.11	5.11	NUM
eurjchem-1346	398	26	ppm	ppm	NOUN
eurjchem-1346	398	27	corresponding	correspond	VERB
eurjchem-1346	398	28	to	to	ADP
eurjchem-1346	398	29	ch	ch	NOUN
eurjchem-1346	398	30	=	=	NOUN
eurjchem-1346	398	31	ch	ch	NOUN
eurjchem-1346	398	32	protons	proton	NOUN
eurjchem-1346	398	33	for	for	ADP
eurjchem-1346	398	34	compound	compound	NOUN
eurjchem-1346	398	35	7b	7b	NOUN
eurjchem-1346	398	36	or	or	CCONJ
eurjchem-1346	398	37	additional	additional	ADJ
eurjchem-1346	398	38	multiplet	multiplet	NOUN
eurjchem-1346	398	39	signal	signal	NOUN
eurjchem-1346	398	40	at	at	ADP
eurjchem-1346	398	41	δ	δ	PROPN
eurjchem-1346	398	42	7.66‐8.11	7.66‐8.11	PROPN
eurjchem-1346	398	43	ppm	ppm	NOUN
eurjchem-1346	398	44	attributed	attribute	VERB
eurjchem-1346	398	45	to	to	ADP
eurjchem-1346	398	46	added	add	VERB
eurjchem-1346	398	47	aromatic	aromatic	ADJ
eurjchem-1346	398	48	protons	proton	NOUN
eurjchem-1346	398	49	for	for	ADP
eurjchem-1346	398	50	compound	compound	NOUN
eurjchem-1346	398	51	7c	7c	NOUN
eurjchem-1346	398	52	.	.	PUNCT
eurjchem-1346	399	1	3.2	3.2	NUM
eurjchem-1346	399	2	.	.	PUNCT
eurjchem-1346	400	1	biological	biological	ADJ
eurjchem-1346	400	2	activity	activity	NOUN
eurjchem-1346	400	3	3.2.1	3.2.1	NUM
eurjchem-1346	400	4	.	.	PUNCT
eurjchem-1346	401	1	antitumor	antitumor	PROPN
eurjchem-1346	401	2	screening	screen	VERB
eurjchem-1346	401	3	cell	cell	NOUN
eurjchem-1346	401	4	lines	line	NOUN
eurjchem-1346	401	5	were	be	AUX
eurjchem-1346	401	6	provided	provide	VERB
eurjchem-1346	401	7	by	by	ADP
eurjchem-1346	401	8	american	american	ADJ
eurjchem-1346	401	9	type	type	NOUN
eurjchem-1346	401	10	culture	culture	NOUN
eurjchem-1346	401	11	collection	collection	NOUN
eurjchem-1346	401	12	(	(	PUNCT
eurjchem-1346	401	13	rockville	rockville	PROPN
eurjchem-1346	401	14	,	,	PUNCT
eurjchem-1346	401	15	md	md	PROPN
eurjchem-1346	401	16	)	)	PUNCT
eurjchem-1346	401	17	.	.	PUNCT
eurjchem-1346	402	1	these	these	DET
eurjchem-1346	402	2	cells	cell	NOUN
eurjchem-1346	402	3	were	be	AUX
eurjchem-1346	402	4	grown	grow	VERB
eurjchem-1346	402	5	in	in	ADP
eurjchem-1346	402	6	rpmi‐	rpmi‐	ADJ
eurjchem-1346	402	7	1640	1640	NUM
eurjchem-1346	402	8	;	;	PUNCT
eurjchem-1346	402	9	all	all	PRON
eurjchem-1346	402	10	supplemented	supplement	VERB
eurjchem-1346	402	11	with	with	ADP
eurjchem-1346	402	12	10	10	NUM
eurjchem-1346	402	13	%	%	NOUN
eurjchem-1346	402	14	heat	heat	NOUN
eurjchem-1346	402	15	inactivated	inactivate	VERB
eurjchem-1346	402	16	fetal	fetal	ADJ
eurjchem-1346	402	17	bovine	bovine	NOUN
eurjchem-1346	402	18	serum	serum	NOUN
eurjchem-1346	402	19	(	(	PUNCT
eurjchem-1346	402	20	fbs	fbs	PROPN
eurjchem-1346	402	21	)	)	PUNCT
eurjchem-1346	402	22	,	,	PUNCT
eurjchem-1346	402	23	2	2	NUM
eurjchem-1346	402	24	mm	mm	NOUN
eurjchem-1346	402	25	l‐glutamine	l‐glutamine	PUNCT
eurjchem-1346	402	26	,	,	PUNCT
eurjchem-1346	402	27	and	and	CCONJ
eurjchem-1346	402	28	1	1	NUM
eurjchem-1346	402	29	%	%	NOUN
eurjchem-1346	402	30	penicillin‐	penicillin‐	ADV
eurjchem-1346	402	31	streptomycin	streptomycin	PROPN
eurjchem-1346	402	32	.	.	PUNCT
eurjchem-1346	403	1	dmem	dmem	PROPN
eurjchem-1346	403	2	was	be	AUX
eurjchem-1346	403	3	also	also	ADV
eurjchem-1346	403	4	supplemented	supplement	VERB
eurjchem-1346	403	5	with	with	ADP
eurjchem-1346	403	6	0.01	0.01	NUM
eurjchem-1346	403	7	mg	mg	NOUN
eurjchem-1346	403	8	/	/	SYM
eurjchem-1346	403	9	ml	ml	NOUN
eurjchem-1346	403	10	insulin	insulin	NOUN
eurjchem-1346	403	11	and	and	CCONJ
eurjchem-1346	403	12	1	1	NUM
eurjchem-1346	403	13	mm	mm	NOUN
eurjchem-1346	403	14	sodium	sodium	NOUN
eurjchem-1346	403	15	pyruvate	pyruvate	NOUN
eurjchem-1346	403	16	.	.	PUNCT
eurjchem-1346	404	1	cells	cell	NOUN
eurjchem-1346	404	2	were	be	AUX
eurjchem-1346	404	3	incubated	incubate	VERB
eurjchem-1346	404	4	in	in	ADP
eurjchem-1346	404	5	a	a	DET
eurjchem-1346	404	6	5	5	NUM
eurjchem-1346	404	7	%	%	NOUN
eurjchem-1346	404	8	co2	co2	NOUN
eurjchem-1346	404	9	humidified	humidify	VERB
eurjchem-1346	404	10	incubator	incubator	NOUN
eurjchem-1346	404	11	at	at	ADP
eurjchem-1346	404	12	37	37	NUM
eurjchem-1346	404	13	°	°	ADP
eurjchem-1346	404	14	c	c	NOUN
eurjchem-1346	404	15	and	and	CCONJ
eurjchem-1346	404	16	passaged	passage	VERB
eurjchem-1346	404	17	bi‐weekly	bi‐weekly	ADV
eurjchem-1346	404	18	.	.	PUNCT
eurjchem-1346	405	1	all	all	DET
eurjchem-1346	405	2	the	the	DET
eurjchem-1346	405	3	synthesized	synthesize	VERB
eurjchem-1346	405	4	compounds	compound	NOUN
eurjchem-1346	405	5	were	be	AUX
eurjchem-1346	405	6	subjected	subject	VERB
eurjchem-1346	405	7	to	to	ADP
eurjchem-1346	405	8	in	in	ADP
eurjchem-1346	405	9	vitro	vitro	X
eurjchem-1346	405	10	tumor	tumor	NOUN
eurjchem-1346	405	11	growth	growth	NOUN
eurjchem-1346	405	12	inhibitory	inhibitory	ADJ
eurjchem-1346	405	13	activity	activity	NOUN
eurjchem-1346	405	14	against	against	ADP
eurjchem-1346	405	15	eight	eight	NUM
eurjchem-1346	405	16	different	different	ADJ
eurjchem-1346	405	17	cell	cell	NOUN
eurjchem-1346	405	18	lines	line	NOUN
eurjchem-1346	405	19	of	of	ADP
eurjchem-1346	405	20	human	human	ADJ
eurjchem-1346	405	21	cancer	cancer	NOUN
eurjchem-1346	405	22	cells	cell	NOUN
eurjchem-1346	405	23	.	.	PUNCT
eurjchem-1346	406	1	the	the	DET
eurjchem-1346	406	2	cytotoxicity	cytotoxicity	NOUN
eurjchem-1346	406	3	of	of	ADP
eurjchem-1346	406	4	the	the	DET
eurjchem-1346	406	5	newly	newly	ADV
eurjchem-1346	406	6	synthesized	synthesize	VERB
eurjchem-1346	406	7	compounds	compound	NOUN
eurjchem-1346	406	8	against	against	ADP
eurjchem-1346	406	9	cancer	cancer	NOUN
eurjchem-1346	406	10	cell	cell	NOUN
eurjchem-1346	406	11	lines	line	NOUN
eurjchem-1346	406	12	in	in	ADP
eurjchem-1346	406	13	vitro	vitro	X
eurjchem-1346	406	14	was	be	AUX
eurjchem-1346	406	15	performed	perform	VERB
eurjchem-1346	406	16	with	with	ADP
eurjchem-1346	406	17	the	the	DET
eurjchem-1346	406	18	mtt	mtt	NOUN
eurjchem-1346	406	19	assay	assay	VERB
eurjchem-1346	406	20	according	accord	VERB
eurjchem-1346	406	21	to	to	ADP
eurjchem-1346	406	22	the	the	DET
eurjchem-1346	406	23	mosmann	mosmann	PROPN
eurjchem-1346	406	24	’s	’s	PART
eurjchem-1346	406	25	method	method	NOUN
eurjchem-1346	406	26	[	[	X
eurjchem-1346	406	27	23	23	NUM
eurjchem-1346	406	28	]	]	PUNCT
eurjchem-1346	406	29	.	.	PUNCT
eurjchem-1346	407	1	the	the	DET
eurjchem-1346	407	2	mtt	mtt	NOUN
eurjchem-1346	407	3	assay	assay	VERB
eurjchem-1346	407	4	is	be	AUX
eurjchem-1346	407	5	based	base	VERB
eurjchem-1346	407	6	on	on	ADP
eurjchem-1346	407	7	the	the	DET
eurjchem-1346	407	8	reduction	reduction	NOUN
eurjchem-1346	407	9	of	of	ADP
eurjchem-1346	407	10	the	the	DET
eurjchem-1346	407	11	soluble	soluble	ADJ
eurjchem-1346	407	12	3‐(4,5‐methyl‐2‐thiazolyl)‐2,5‐diphenyl‐2h‐tetrazo‐	3‐(4,5‐methyl‐2‐thiazolyl)‐2,5‐diphenyl‐2h‐tetrazo‐	NUM
eurjchem-1346	407	13	lium	lium	ADJ
eurjchem-1346	407	14	bromide	bromide	NOUN
eurjchem-1346	407	15	(	(	PUNCT
eurjchem-1346	407	16	mtt	mtt	NOUN
eurjchem-1346	407	17	)	)	PUNCT
eurjchem-1346	407	18	into	into	ADP
eurjchem-1346	407	19	a	a	DET
eurjchem-1346	407	20	blue‐purple	blue‐purple	NOUN
eurjchem-1346	407	21	formazan	formazan	ADJ
eurjchem-1346	407	22	product	product	NOUN
eurjchem-1346	407	23	,	,	PUNCT
eurjchem-1346	407	24	mainly	mainly	ADV
eurjchem-1346	407	25	by	by	ADP
eurjchem-1346	407	26	mitochondrial	mitochondrial	ADJ
eurjchem-1346	407	27	reductase	reductase	NOUN
eurjchem-1346	407	28	activity	activity	NOUN
eurjchem-1346	407	29	inside	inside	ADP
eurjchem-1346	407	30	living	living	NOUN
eurjchem-1346	407	31	cells	cell	NOUN
eurjchem-1346	407	32	.	.	PUNCT
eurjchem-1346	408	1	results	result	NOUN
eurjchem-1346	408	2	were	be	AUX
eurjchem-1346	408	3	expressed	express	VERB
eurjchem-1346	408	4	in	in	ADP
eurjchem-1346	408	5	term	term	NOUN
eurjchem-1346	408	6	of	of	ADP
eurjchem-1346	408	7	ic50	ic50	PROPN
eurjchem-1346	408	8	[	[	X
eurjchem-1346	408	9	μm	μm	X
eurjchem-1346	408	10	]	]	X
eurjchem-1346	408	11	(	(	PUNCT
eurjchem-1346	408	12	table	table	NOUN
eurjchem-1346	408	13	1	1	NUM
eurjchem-1346	408	14	)	)	PUNCT
eurjchem-1346	408	15	.	.	PUNCT
eurjchem-1346	409	1	all	all	DET
eurjchem-1346	409	2	newly	newly	ADV
eurjchem-1346	409	3	synthesized	synthesize	VERB
eurjchem-1346	409	4	compounds	compound	NOUN
eurjchem-1346	409	5	showed	show	VERB
eurjchem-1346	409	6	various	various	ADJ
eurjchem-1346	409	7	activity	activity	NOUN
eurjchem-1346	409	8	against	against	ADP
eurjchem-1346	409	9	different	different	ADJ
eurjchem-1346	409	10	cell	cell	NOUN
eurjchem-1346	409	11	lines	line	NOUN
eurjchem-1346	409	12	compared	compare	VERB
eurjchem-1346	409	13	with	with	ADP
eurjchem-1346	409	14	sorafenib	sorafenib	NOUN
eurjchem-1346	409	15	.	.	PUNCT
eurjchem-1346	410	1	com‐	com‐	ADJ
eurjchem-1346	410	2	pound	pound	NOUN
eurjchem-1346	410	3	7c	7c	PROPN
eurjchem-1346	410	4	showed	show	VERB
eurjchem-1346	410	5	good	good	ADJ
eurjchem-1346	410	6	activity	activity	NOUN
eurjchem-1346	410	7	among	among	ADP
eurjchem-1346	410	8	the	the	DET
eurjchem-1346	410	9	tested	test	VERB
eurjchem-1346	410	10	compounds	compound	NOUN
eurjchem-1346	410	11	against	against	ADP
eurjchem-1346	410	12	melanoma	melanoma	NOUN
eurjchem-1346	410	13	(	(	PUNCT
eurjchem-1346	410	14	loximvi	loximvi	NOUN
eurjchem-1346	410	15	)	)	PUNCT
eurjchem-1346	410	16	cell	cell	NOUN
eurjchem-1346	410	17	line	line	NOUN
eurjchem-1346	410	18	(	(	PUNCT
eurjchem-1346	410	19	ic50	ic50	PROPN
eurjchem-1346	410	20	=	=	PUNCT
eurjchem-1346	410	21	0.0045	0.0045	NUM
eurjchem-1346	410	22	μm	μm	NUM
eurjchem-1346	410	23	)	)	PUNCT
eurjchem-1346	410	24	compared	compare	VERB
eurjchem-1346	410	25	to	to	ADP
eurjchem-1346	410	26	sorafenib	sorafenib	PROPN
eurjchem-1346	410	27	(	(	PUNCT
eurjchem-1346	410	28	ic50	ic50	PROPN
eurjchem-1346	410	29	=	=	SYM
eurjchem-1346	410	30	0.0034	0.0034	NUM
eurjchem-1346	410	31	μm	μm	NUM
eurjchem-1346	410	32	)	)	PUNCT
eurjchem-1346	410	33	.	.	PUNCT
eurjchem-1346	411	1	however	however	ADV
eurjchem-1346	411	2	,	,	PUNCT
eurjchem-1346	411	3	compounds	compound	VERB
eurjchem-1346	411	4	3c	3c	NUM
eurjchem-1346	411	5	,	,	PUNCT
eurjchem-1346	411	6	d	d	PROPN
eurjchem-1346	411	7	,	,	PUNCT
eurjchem-1346	411	8	j	j	PROPN
eurjchem-1346	411	9	were	be	AUX
eurjchem-1346	411	10	more	more	ADV
eurjchem-1346	411	11	active	active	ADJ
eurjchem-1346	411	12	than	than	ADP
eurjchem-1346	411	13	sorafenib	sorafenib	NOUN
eurjchem-1346	411	14	against	against	ADP
eurjchem-1346	411	15	ovarian	ovarian	ADJ
eurjchem-1346	411	16	cell	cell	NOUN
eurjchem-1346	411	17	line	line	NOUN
eurjchem-1346	411	18	(	(	PUNCT
eurjchem-1346	411	19	ovcar3	ovcar3	ADJ
eurjchem-1346	411	20	)	)	PUNCT
eurjchem-1346	411	21	as	as	SCONJ
eurjchem-1346	411	22	they	they	PRON
eurjchem-1346	411	23	exhibited	exhibit	VERB
eurjchem-1346	411	24	lower	low	ADJ
eurjchem-1346	411	25	ic50	ic50	PROPN
eurjchem-1346	411	26	(	(	PUNCT
eurjchem-1346	411	27	0.00456‐0.043	0.00456‐0.043	PROPN
eurjchem-1346	411	28	μm	μm	NUM
eurjchem-1346	411	29	)	)	PUNCT
eurjchem-1346	411	30	than	than	ADP
eurjchem-1346	411	31	that	that	PRON
eurjchem-1346	411	32	of	of	ADP
eurjchem-1346	411	33	sorafenib	sorafenib	NOUN
eurjchem-1346	411	34	(	(	PUNCT
eurjchem-1346	411	35	0.12	0.12	NUM
eurjchem-1346	411	36	μm	μm	NUM
eurjchem-1346	411	37	)	)	PUNCT
eurjchem-1346	411	38	.	.	PUNCT
eurjchem-1346	412	1	on	on	ADP
eurjchem-1346	412	2	the	the	DET
eurjchem-1346	412	3	other	other	ADJ
eurjchem-1346	412	4	hand	hand	NOUN
eurjchem-1346	412	5	,	,	PUNCT
eurjchem-1346	412	6	compounds	compound	VERB
eurjchem-1346	412	7	3b‐f	3b‐f	PROPN
eurjchem-1346	412	8	,	,	PUNCT
eurjchem-1346	412	9	5a	5a	NUM
eurjchem-1346	412	10	,	,	PUNCT
eurjchem-1346	412	11	6b‐d	6b‐d	NOUN
eurjchem-1346	412	12	and	and	CCONJ
eurjchem-1346	412	13	7a‐c	7a‐c	NOUN
eurjchem-1346	412	14	exhibited	exhibit	VERB
eurjchem-1346	412	15	higher	high	ADJ
eurjchem-1346	412	16	activity	activity	NOUN
eurjchem-1346	412	17	than	than	ADP
eurjchem-1346	412	18	sorafenib	sorafenib	NOUN
eurjchem-1346	412	19	(	(	PUNCT
eurjchem-1346	412	20	ic50	ic50	PROPN
eurjchem-1346	412	21	0.17	0.17	NUM
eurjchem-1346	412	22	μm	μm	NOUN
eurjchem-1346	412	23	)	)	PUNCT
eurjchem-1346	412	24	against	against	ADP
eurjchem-1346	412	25	thyroid	thyroid	NOUN
eurjchem-1346	412	26	cell	cell	NOUN
eurjchem-1346	412	27	line	line	NOUN
eurjchem-1346	412	28	(	(	PUNCT
eurjchem-1346	412	29	cal62	cal62	NOUN
eurjchem-1346	412	30	)	)	PUNCT
eurjchem-1346	412	31	as	as	SCONJ
eurjchem-1346	412	32	they	they	PRON
eurjchem-1346	412	33	showed	show	VERB
eurjchem-1346	412	34	lower	low	ADJ
eurjchem-1346	412	35	ic50	ic50	PROPN
eurjchem-1346	412	36	(	(	PUNCT
eurjchem-1346	412	37	0.003‐0.094	0.003‐0.094	NUM
eurjchem-1346	413	1	μm	μm	X
eurjchem-1346	413	2	)	)	PUNCT
eurjchem-1346	413	3	while	while	SCONJ
eurjchem-1346	413	4	compounds	compound	NOUN
eurjchem-1346	413	5	1	1	NUM
eurjchem-1346	413	6	and	and	CCONJ
eurjchem-1346	413	7	3j	3j	NOUN
eurjchem-1346	413	8	showed	show	VERB
eurjchem-1346	413	9	comparable	comparable	ADJ
eurjchem-1346	413	10	activity	activity	NOUN
eurjchem-1346	413	11	with	with	ADP
eurjchem-1346	413	12	sorafenib	sorafenib	NOUN
eurjchem-1346	413	13	(	(	PUNCT
eurjchem-1346	413	14	ic50	ic50	PROPN
eurjchem-1346	413	15	=	=	PROPN
eurjchem-1346	413	16	0.12	0.12	NUM
eurjchem-1346	413	17	and	and	CCONJ
eurjchem-1346	413	18	0.15	0.15	NUM
eurjchem-1346	413	19	μm	μm	NOUN
eurjchem-1346	413	20	,	,	PUNCT
eurjchem-1346	413	21	respectively	respectively	ADV
eurjchem-1346	413	22	)	)	PUNCT
eurjchem-1346	413	23	.	.	PUNCT
eurjchem-1346	414	1	compounds	compound	VERB
eurjchem-1346	414	2	3	3	NUM
eurjchem-1346	414	3	g	g	NOUN
eurjchem-1346	414	4	,	,	PUNCT
eurjchem-1346	414	5	j	j	PROPN
eurjchem-1346	414	6	and	and	CCONJ
eurjchem-1346	414	7	5a	5a	NUM
eurjchem-1346	414	8	showed	show	VERB
eurjchem-1346	414	9	higher	high	ADJ
eurjchem-1346	414	10	activity	activity	NOUN
eurjchem-1346	414	11	than	than	ADP
eurjchem-1346	414	12	sorafenib	sorafenib	NOUN
eurjchem-1346	414	13	(	(	PUNCT
eurjchem-1346	414	14	ic50	ic50	PROPN
eurjchem-1346	414	15	0.006	0.006	NUM
eurjchem-1346	414	16	μm	μm	NUM
eurjchem-1346	414	17	)	)	PUNCT
eurjchem-1346	414	18	against	against	ADP
eurjchem-1346	414	19	thyroid	thyroid	NOUN
eurjchem-1346	414	20	cell	cell	NOUN
eurjchem-1346	414	21	line	line	NOUN
eurjchem-1346	414	22	(	(	PUNCT
eurjchem-1346	414	23	ftc133	ftc133	PROPN
eurjchem-1346	414	24	)	)	PUNCT
eurjchem-1346	414	25	as	as	SCONJ
eurjchem-1346	414	26	they	they	PRON
eurjchem-1346	414	27	exhibited	exhibit	VERB
eurjchem-1346	414	28	lower	low	ADJ
eurjchem-1346	414	29	ic50	ic50	PROPN
eurjchem-1346	414	30	(	(	PUNCT
eurjchem-1346	414	31	0.0032‐0.0043	0.0032‐0.0043	NOUN
eurjchem-1346	414	32	μm	μm	NOUN
eurjchem-1346	414	33	)	)	PUNCT
eurjchem-1346	414	34	while	while	SCONJ
eurjchem-1346	414	35	compound	compound	NOUN
eurjchem-1346	414	36	3h	3h	NUM
eurjchem-1346	414	37	showed	show	VERB
eurjchem-1346	414	38	comparable	comparable	ADJ
eurjchem-1346	414	39	activity	activity	NOUN
eurjchem-1346	414	40	with	with	ADP
eurjchem-1346	414	41	sorafenib	sorafenib	NOUN
eurjchem-1346	414	42	at	at	ADP
eurjchem-1346	414	43	this	this	DET
eurjchem-1346	414	44	cell	cell	NOUN
eurjchem-1346	414	45	line	line	NOUN
eurjchem-1346	414	46	(	(	PUNCT
eurjchem-1346	414	47	0.0056	0.0056	NUM
eurjchem-1346	414	48	μm	μm	NUM
eurjchem-1346	414	49	)	)	PUNCT
eurjchem-1346	414	50	.	.	PUNCT
eurjchem-1346	415	1	in	in	ADP
eurjchem-1346	415	2	addition	addition	NOUN
eurjchem-1346	415	3	,	,	PUNCT
eurjchem-1346	415	4	compounds	compound	VERB
eurjchem-1346	415	5	3f	3f	PROPN
eurjchem-1346	415	6	and	and	CCONJ
eurjchem-1346	415	7	7b	7b	NUM
eurjchem-1346	415	8	were	be	AUX
eurjchem-1346	415	9	more	more	ADV
eurjchem-1346	415	10	active	active	ADJ
eurjchem-1346	415	11	than	than	ADP
eurjchem-1346	415	12	sorafenib	sorafenib	NOUN
eurjchem-1346	415	13	against	against	ADP
eurjchem-1346	415	14	thyroid	thyroid	NOUN
eurjchem-1346	415	15	cell	cell	NOUN
eurjchem-1346	415	16	line	line	NOUN
eurjchem-1346	415	17	(	(	PUNCT
eurjchem-1346	415	18	bcpap	bcpap	NOUN
eurjchem-1346	415	19	)	)	PUNCT
eurjchem-1346	415	20	as	as	SCONJ
eurjchem-1346	415	21	they	they	PRON
eurjchem-1346	415	22	exhibited	exhibit	VERB
eurjchem-1346	415	23	lower	low	ADJ
eurjchem-1346	415	24	ic50	ic50	PROPN
eurjchem-1346	415	25	(	(	PUNCT
eurjchem-1346	415	26	0.08054	0.08054	NUM
eurjchem-1346	415	27	and	and	CCONJ
eurjchem-1346	415	28	0.064	0.064	NUM
eurjchem-1346	415	29	μm	μm	NUM
eurjchem-1346	415	30	,	,	PUNCT
eurjchem-1346	415	31	respectively	respectively	ADV
eurjchem-1346	415	32	)	)	PUNCT
eurjchem-1346	415	33	compared	compare	VERB
eurjchem-1346	415	34	to	to	ADP
eurjchem-1346	415	35	ic50	ic50	PROPN
eurjchem-1346	415	36	of	of	ADP
eurjchem-1346	415	37	sorafenib	sorafenib	NOUN
eurjchem-1346	415	38	(	(	PUNCT
eurjchem-1346	415	39	0.087	0.087	NUM
eurjchem-1346	415	40	μm	μm	NUM
eurjchem-1346	415	41	)	)	PUNCT
eurjchem-1346	415	42	while	while	SCONJ
eurjchem-1346	415	43	compounds	compound	NOUN
eurjchem-1346	415	44	3d	3d	NUM
eurjchem-1346	415	45	,	,	PUNCT
eurjchem-1346	415	46	e	e	NOUN
eurjchem-1346	415	47	,	,	PUNCT
eurjchem-1346	415	48	6d	6d	NUM
eurjchem-1346	415	49	and	and	CCONJ
eurjchem-1346	415	50	7c	7c	PROPN
eurjchem-1346	415	51	showed	show	VERB
eurjchem-1346	415	52	comparable	comparable	ADJ
eurjchem-1346	415	53	activity	activity	NOUN
eurjchem-1346	415	54	with	with	ADP
eurjchem-1346	415	55	sorafenib	sorafenib	NOUN
eurjchem-1346	415	56	against	against	ADP
eurjchem-1346	415	57	this	this	DET
eurjchem-1346	415	58	cell	cell	NOUN
eurjchem-1346	415	59	line	line	NOUN
eurjchem-1346	415	60	as	as	SCONJ
eurjchem-1346	415	61	they	they	PRON
eurjchem-1346	415	62	exhibited	exhibit	VERB
eurjchem-1346	415	63	ic50	ic50	PROPN
eurjchem-1346	415	64	(	(	PUNCT
eurjchem-1346	415	65	0.085‐0.09	0.085‐0.09	PROPN
eurjchem-1346	415	66	μm	μm	NUM
eurjchem-1346	415	67	)	)	PUNCT
eurjchem-1346	415	68	.	.	PUNCT
eurjchem-1346	416	1	moreover	moreover	ADV
eurjchem-1346	416	2	,	,	PUNCT
eurjchem-1346	416	3	compounds	compound	NOUN
eurjchem-1346	416	4	1	1	NUM
eurjchem-1346	416	5	,	,	PUNCT
eurjchem-1346	416	6	2	2	NUM
eurjchem-1346	416	7	,	,	PUNCT
eurjchem-1346	416	8	3a‐d	3a‐d	ADV
eurjchem-1346	416	9	,	,	PUNCT
eurjchem-1346	416	10	4	4	NUM
eurjchem-1346	416	11	,	,	PUNCT
eurjchem-1346	416	12	5a	5a	NUM
eurjchem-1346	416	13	,	,	PUNCT
eurjchem-1346	416	14	b	b	NOUN
eurjchem-1346	416	15	,	,	PUNCT
eurjchem-1346	416	16	6b	6b	NOUN
eurjchem-1346	416	17	and	and	CCONJ
eurjchem-1346	416	18	7b	7b	NUM
eurjchem-1346	416	19	,	,	PUNCT
eurjchem-1346	416	20	c	c	PROPN
eurjchem-1346	416	21	were	be	AUX
eurjchem-1346	416	22	more	more	ADV
eurjchem-1346	416	23	active	active	ADJ
eurjchem-1346	416	24	than	than	ADP
eurjchem-1346	416	25	sorafenib	sorafenib	NOUN
eurjchem-1346	416	26	against	against	ADP
eurjchem-1346	416	27	thyroid	thyroid	NOUN
eurjchem-1346	416	28	cell	cell	NOUN
eurjchem-1346	416	29	line	line	NOUN
eurjchem-1346	416	30	(	(	PUNCT
eurjchem-1346	416	31	ml1	ml1	NOUN
eurjchem-1346	416	32	)	)	PUNCT
eurjchem-1346	416	33	as	as	SCONJ
eurjchem-1346	416	34	revealed	reveal	VERB
eurjchem-1346	416	35	from	from	ADP
eurjchem-1346	416	36	lower	low	ADJ
eurjchem-1346	416	37	ic50	ic50	PROPN
eurjchem-1346	416	38	(	(	PUNCT
eurjchem-1346	416	39	0.10‐0.58	0.10‐0.58	NOUN
eurjchem-1346	416	40	μm	μm	NUM
eurjchem-1346	416	41	)	)	PUNCT
eurjchem-1346	416	42	compared	compare	VERB
eurjchem-1346	416	43	to	to	ADP
eurjchem-1346	416	44	ic50	ic50	PROPN
eurjchem-1346	416	45	of	of	ADP
eurjchem-1346	416	46	sorafenib	sorafenib	NOUN
eurjchem-1346	416	47	(	(	PUNCT
eurjchem-1346	416	48	0.61	0.61	NUM
eurjchem-1346	416	49	μm	μm	NUM
eurjchem-1346	416	50	)	)	PUNCT
eurjchem-1346	416	51	while	while	SCONJ
eurjchem-1346	416	52	compounds	compound	NOUN
eurjchem-1346	416	53	3e	3e	NOUN
eurjchem-1346	416	54	,	,	PUNCT
eurjchem-1346	416	55	j	j	PROPN
eurjchem-1346	416	56	showed	show	VERB
eurjchem-1346	416	57	comparable	comparable	ADJ
eurjchem-1346	416	58	activity	activity	NOUN
eurjchem-1346	416	59	with	with	ADP
eurjchem-1346	416	60	sorafenib	sorafenib	NOUN
eurjchem-1346	416	61	against	against	ADP
eurjchem-1346	416	62	this	this	DET
eurjchem-1346	416	63	cell	cell	NOUN
eurjchem-1346	416	64	line	line	NOUN
eurjchem-1346	416	65	as	as	SCONJ
eurjchem-1346	416	66	they	they	PRON
eurjchem-1346	416	67	exhibited	exhibit	VERB
eurjchem-1346	416	68	ic50	ic50	PROPN
eurjchem-1346	416	69	(	(	PUNCT
eurjchem-1346	416	70	0.60	0.60	NUM
eurjchem-1346	416	71	and	and	CCONJ
eurjchem-1346	416	72	0.64	0.64	NUM
eurjchem-1346	416	73	μm	μm	NUM
eurjchem-1346	416	74	,	,	PUNCT
eurjchem-1346	416	75	respectively	respectively	ADV
eurjchem-1346	416	76	)	)	PUNCT
eurjchem-1346	416	77	.	.	PUNCT
eurjchem-1346	417	1	on	on	ADP
eurjchem-1346	417	2	the	the	DET
eurjchem-1346	417	3	other	other	ADJ
eurjchem-1346	417	4	hand	hand	NOUN
eurjchem-1346	417	5	,	,	PUNCT
eurjchem-1346	417	6	compounds	compound	VERB
eurjchem-1346	417	7	3d‐i	3d‐i	PROPN
eurjchem-1346	417	8	exhibited	exhibit	VERB
eurjchem-1346	417	9	promising	promising	ADJ
eurjchem-1346	417	10	activity	activity	NOUN
eurjchem-1346	417	11	against	against	ADP
eurjchem-1346	417	12	colon	colon	NOUN
eurjchem-1346	417	13	cell	cell	NOUN
eurjchem-1346	417	14	lines	line	NOUN
eurjchem-1346	417	15	ht29	ht29	PROPN
eurjchem-1346	417	16	and	and	CCONJ
eurjchem-1346	417	17	hct116	hct116	ADV
eurjchem-1346	417	18	than	than	ADP
eurjchem-1346	417	19	sorafenib	sorafenib	NOUN
eurjchem-1346	417	20	as	as	SCONJ
eurjchem-1346	417	21	they	they	PRON
eurjchem-1346	417	22	exhibited	exhibit	VERB
eurjchem-1346	417	23	much	much	ADV
eurjchem-1346	417	24	lower	low	ADJ
eurjchem-1346	417	25	ic50	ic50	PROPN
eurjchem-1346	417	26	(	(	PUNCT
eurjchem-1346	417	27	0.00032‐0.00078	0.00032‐0.00078	PROPN
eurjchem-1346	417	28	μm	μm	NUM
eurjchem-1346	417	29	)	)	PUNCT
eurjchem-1346	417	30	compared	compare	VERB
eurjchem-1346	417	31	to	to	ADP
eurjchem-1346	417	32	ic50	ic50	PROPN
eurjchem-1346	417	33	of	of	ADP
eurjchem-1346	417	34	sorafenib	sorafenib	NOUN
eurjchem-1346	417	35	(	(	PUNCT
eurjchem-1346	417	36	0.73	0.73	NUM
eurjchem-1346	417	37	and	and	CCONJ
eurjchem-1346	417	38	0.18	0.18	NUM
eurjchem-1346	417	39	μm	μm	NUM
eurjchem-1346	417	40	,	,	PUNCT
eurjchem-1346	417	41	respectively	respectively	ADV
eurjchem-1346	417	42	)	)	PUNCT
eurjchem-1346	417	43	.	.	PUNCT
eurjchem-1346	418	1	26	26	NUM
eurjchem-1346	418	2	amin	amin	NOUN
eurjchem-1346	418	3	et	et	PROPN
eurjchem-1346	418	4	al	al	PROPN
eurjchem-1346	418	5	.	.	PUNCT
eurjchem-1346	418	6	/	/	SYM
eurjchem-1346	418	7	european	european	PROPN
eurjchem-1346	418	8	journal	journal	PROPN
eurjchem-1346	418	9	of	of	ADP
eurjchem-1346	418	10	chemistry	chemistry	NOUN
eurjchem-1346	418	11	7	7	NUM
eurjchem-1346	418	12	(	(	PUNCT
eurjchem-1346	418	13	1	1	NUM
eurjchem-1346	418	14	)	)	PUNCT
eurjchem-1346	418	15	(	(	PUNCT
eurjchem-1346	418	16	2016	2016	NUM
eurjchem-1346	418	17	)	)	PUNCT
eurjchem-1346	418	18	19‐29	19‐29	NUM
eurjchem-1346	418	19	table	table	NOUN
eurjchem-1346	418	20	1	1	NUM
eurjchem-1346	418	21	.	.	PUNCT
eurjchem-1346	419	1	in	in	ADP
eurjchem-1346	419	2	vitro	vitro	X
eurjchem-1346	419	3	growth	growth	NOUN
eurjchem-1346	419	4	inhibitory	inhibitory	ADJ
eurjchem-1346	419	5	activity	activity	NOUN
eurjchem-1346	419	6	(	(	PUNCT
eurjchem-1346	419	7	ic50	ic50	PROPN
eurjchem-1346	419	8	,	,	PUNCT
eurjchem-1346	419	9	μm	μm	NUM
eurjchem-1346	419	10	)	)	PUNCT
eurjchem-1346	419	11	against	against	ADP
eurjchem-1346	419	12	melanoma	melanoma	NOUN
eurjchem-1346	419	13	,	,	PUNCT
eurjchem-1346	419	14	thyroid	thyroid	NOUN
eurjchem-1346	419	15	,	,	PUNCT
eurjchem-1346	419	16	and	and	CCONJ
eurjchem-1346	419	17	ovarian	ovarian	ADJ
eurjchem-1346	419	18	cell	cell	NOUN
eurjchem-1346	419	19	lines	line	NOUN
eurjchem-1346	419	20	.	.	PUNCT
eurjchem-1346	420	1	compound	compound	NOUN
eurjchem-1346	420	2	melanoma	melanoma	PROPN
eurjchem-1346	420	3	ovarian	ovarian	ADJ
eurjchem-1346	420	4	thyroid	thyroid	NOUN
eurjchem-1346	420	5	colon	colon	NOUN
eurjchem-1346	420	6	loximvi	loximvi	PROPN
eurjchem-1346	420	7	ovcar3	ovcar3	X
eurjchem-1346	421	1	cal62	cal62	NOUN
eurjchem-1346	421	2	ftc133	ftc133	PROPN
eurjchem-1346	421	3	bcpap	bcpap	PROPN
eurjchem-1346	422	1	ml1	ml1	PROPN
eurjchem-1346	423	1	ht29	ht29	PROPN
eurjchem-1346	423	2	hct116	hct116	PROPN
eurjchem-1346	423	3	1	1	NUM
eurjchem-1346	423	4	1.45	1.45	NUM
eurjchem-1346	423	5	1.34	1.34	NUM
eurjchem-1346	423	6	0.12	0.12	NUM
eurjchem-1346	423	7	0.21	0.21	NUM
eurjchem-1346	423	8	0.13	0.13	NUM
eurjchem-1346	423	9	0.17	0.17	NUM
eurjchem-1346	423	10	1.23	1.23	NUM
eurjchem-1346	423	11	*	*	PUNCT
eurjchem-1346	423	12	2	2	NUM
eurjchem-1346	423	13	2.67	2.67	NUM
eurjchem-1346	423	14	2.35	2.35	NUM
eurjchem-1346	423	15	0.32	0.32	NUM
eurjchem-1346	423	16	0.26	0.26	NUM
eurjchem-1346	423	17	0.24	0.24	NUM
eurjchem-1346	423	18	0.26	0.26	NUM
eurjchem-1346	423	19	5.43	5.43	NUM
eurjchem-1346	423	20	7.66	7.66	NUM
eurjchem-1346	423	21	3a	3a	NUM
eurjchem-1346	423	22	4.54	4.54	NUM
eurjchem-1346	423	23	8.76	8.76	NUM
eurjchem-1346	423	24	0.45	0.45	NUM
eurjchem-1346	423	25	0.53	0.53	NUM
eurjchem-1346	423	26	0.54	0.54	NUM
eurjchem-1346	423	27	0.35	0.35	NUM
eurjchem-1346	423	28	*	*	PUNCT
eurjchem-1346	424	1	*	*	PUNCT
eurjchem-1346	424	2	3b	3b	NUM
eurjchem-1346	424	3	6.34	6.34	NUM
eurjchem-1346	424	4	3.56	3.56	NUM
eurjchem-1346	424	5	0.09	0.09	NUM
eurjchem-1346	424	6	0.68	0.68	NUM
eurjchem-1346	424	7	0.67	0.67	NUM
eurjchem-1346	424	8	0.28	0.28	NUM
eurjchem-1346	424	9	8.78	8.78	NUM
eurjchem-1346	424	10	4.56	4.56	NUM
eurjchem-1346	424	11	3c	3c	NUM
eurjchem-1346	424	12	5.40	5.40	NUM
eurjchem-1346	424	13	0.00456	0.00456	NUM
eurjchem-1346	424	14	0.0065	0.0065	NUM
eurjchem-1346	424	15	0.98	0.98	NUM
eurjchem-1346	424	16	0.89	0.89	NUM
eurjchem-1346	424	17	0.39	0.39	NUM
eurjchem-1346	424	18	0.98	0.98	NUM
eurjchem-1346	424	19	5.44	5.44	NUM
eurjchem-1346	424	20	3d	3d	NUM
eurjchem-1346	424	21	0.023	0.023	NUM
eurjchem-1346	424	22	0.043	0.043	NUM
eurjchem-1346	424	23	0.0095	0.0095	NUM
eurjchem-1346	424	24	0.09	0.09	NUM
eurjchem-1346	424	25	0.09	0.09	NUM
eurjchem-1346	424	26	0.40	0.40	NUM
eurjchem-1346	424	27	0.00034	0.00034	NUM
eurjchem-1346	424	28	0.00032	0.00032	NUM
eurjchem-1346	424	29	3e	3e	NOUN
eurjchem-1346	424	30	6.43	6.43	NUM
eurjchem-1346	424	31	9.39	9.39	NUM
eurjchem-1346	424	32	0.075	0.075	NUM
eurjchem-1346	424	33	0.09	0.09	NUM
eurjchem-1346	424	34	0.09	0.09	NUM
eurjchem-1346	424	35	0.60	0.60	NUM
eurjchem-1346	424	36	0.00056	0.00056	NUM
eurjchem-1346	424	37	0.00056	0.00056	NUM
eurjchem-1346	424	38	3f	3f	PROPN
eurjchem-1346	424	39	12.45	12.45	NUM
eurjchem-1346	424	40	12.56	12.56	NUM
eurjchem-1346	424	41	0.087	0.087	NUM
eurjchem-1346	424	42	0.0098	0.0098	NUM
eurjchem-1346	424	43	0.08054	0.08054	NUM
eurjchem-1346	424	44	0.79	0.79	NUM
eurjchem-1346	424	45	0.00032	0.00032	NUM
eurjchem-1346	424	46	0.00078	0.00078	NUM
eurjchem-1346	424	47	3	3	NUM
eurjchem-1346	424	48	g	g	ADP
eurjchem-1346	424	49	34.43	34.43	NUM
eurjchem-1346	424	50	34.56	34.56	NUM
eurjchem-1346	424	51	0.43	0.43	NUM
eurjchem-1346	424	52	0.0043	0.0043	NUM
eurjchem-1346	424	53	0.56	0.56	NUM
eurjchem-1346	424	54	0.88	0.88	NUM
eurjchem-1346	424	55	0.00035	0.00035	NUM
eurjchem-1346	424	56	0.00065	0.00065	NUM
eurjchem-1346	424	57	3h	3h	NUM
eurjchem-1346	424	58	0.13	0.13	NUM
eurjchem-1346	424	59	23.56	23.56	NUM
eurjchem-1346	424	60	0.57	0.57	NUM
eurjchem-1346	424	61	0.0056	0.0056	NUM
eurjchem-1346	424	62	0.45	0.45	NUM
eurjchem-1346	424	63	0.95	0.95	NUM
eurjchem-1346	424	64	0.00043	0.00043	NUM
eurjchem-1346	424	65	0.00047	0.00047	NUM
eurjchem-1346	424	66	3i	3i	NOUN
eurjchem-1346	424	67	0.43	0.43	NUM
eurjchem-1346	424	68	5.67	5.67	NUM
eurjchem-1346	424	69	0.63	0.63	NUM
eurjchem-1346	424	70	0.0075	0.0075	NUM
eurjchem-1346	424	71	0.11	0.11	NUM
eurjchem-1346	424	72	0.74	0.74	NUM
eurjchem-1346	424	73	0.00047	0.00047	NUM
eurjchem-1346	424	74	0.00065	0.00065	NUM
eurjchem-1346	424	75	3j	3j	NUM
eurjchem-1346	424	76	0.35	0.35	NUM
eurjchem-1346	424	77	0.034	0.034	NUM
eurjchem-1346	424	78	0.15	0.15	NUM
eurjchem-1346	424	79	0.0032	0.0032	NUM
eurjchem-1346	424	80	0.24	0.24	NUM
eurjchem-1346	424	81	0.64	0.64	NUM
eurjchem-1346	424	82	*	*	PUNCT
eurjchem-1346	425	1	*	*	PUNCT
eurjchem-1346	425	2	4	4	NUM
eurjchem-1346	425	3	0.45	0.45	NUM
eurjchem-1346	425	4	0.30	0.30	NUM
eurjchem-1346	425	5	0.34	0.34	NUM
eurjchem-1346	425	6	0.08	0.08	NUM
eurjchem-1346	425	7	0.32	0.32	NUM
eurjchem-1346	425	8	0.55	0.55	NUM
eurjchem-1346	425	9	*	*	PUNCT
eurjchem-1346	426	1	*	*	PUNCT
eurjchem-1346	426	2	5a	5a	NUM
eurjchem-1346	426	3	0.45	0.45	NUM
eurjchem-1346	426	4	0.234	0.234	NUM
eurjchem-1346	426	5	0.003	0.003	NUM
eurjchem-1346	426	6	0.0043	0.0043	NUM
eurjchem-1346	426	7	0.57	0.57	NUM
eurjchem-1346	426	8	0.46	0.46	NUM
eurjchem-1346	426	9	*	*	NUM
eurjchem-1346	426	10	7.50	7.50	NUM
eurjchem-1346	426	11	5b	5b	NUM
eurjchem-1346	426	12	0.45	0.45	NUM
eurjchem-1346	426	13	0.45	0.45	NUM
eurjchem-1346	426	14	0.436	0.436	NUM
eurjchem-1346	426	15	0.034	0.034	NUM
eurjchem-1346	426	16	0.68	0.68	NUM
eurjchem-1346	426	17	0.57	0.57	NUM
eurjchem-1346	426	18	0.098	0.098	NUM
eurjchem-1346	426	19	7.60	7.60	NUM
eurjchem-1346	426	20	5c	5c	NUM
eurjchem-1346	426	21	2.45	2.45	NUM
eurjchem-1346	426	22	0.45	0.45	NUM
eurjchem-1346	426	23	0.576	0.576	NUM
eurjchem-1346	426	24	0.053	0.053	NUM
eurjchem-1346	426	25	0.65	0.65	NUM
eurjchem-1346	426	26	0.68	0.68	NUM
eurjchem-1346	426	27	*	*	PUNCT
eurjchem-1346	426	28	55.70	55.70	NUM
eurjchem-1346	426	29	5d	5d	NUM
eurjchem-1346	426	30	5.78	5.78	NUM
eurjchem-1346	426	31	5.49	5.49	NUM
eurjchem-1346	426	32	0.605	0.605	NUM
eurjchem-1346	426	33	0.072	0.072	NUM
eurjchem-1346	426	34	0.34	0.34	NUM
eurjchem-1346	426	35	0.70	0.70	NUM
eurjchem-1346	426	36	*	*	PUNCT
eurjchem-1346	426	37	32.60	32.60	NUM
eurjchem-1346	426	38	5e	5e	NOUN
eurjchem-1346	426	39	9.28	9.28	NUM
eurjchem-1346	426	40	10.21	10.21	NUM
eurjchem-1346	426	41	0.905	0.905	NUM
eurjchem-1346	426	42	0.098	0.098	NUM
eurjchem-1346	426	43	0.24	0.24	NUM
eurjchem-1346	426	44	0.80	0.80	NUM
eurjchem-1346	426	45	0.433	0.433	NUM
eurjchem-1346	426	46	12.70	12.70	NUM
eurjchem-1346	426	47	6a	6a	NOUN
eurjchem-1346	426	48	3.29	3.29	NUM
eurjchem-1346	426	49	10.11	10.11	NUM
eurjchem-1346	426	50	0.874	0.874	NUM
eurjchem-1346	426	51	0.0086	0.0086	NUM
eurjchem-1346	426	52	0.56	0.56	NUM
eurjchem-1346	426	53	0.90	0.90	NUM
eurjchem-1346	426	54	23.56	23.56	NUM
eurjchem-1346	426	55	*	*	PUNCT
eurjchem-1346	426	56	6b	6b	NUM
eurjchem-1346	426	57	5.69	5.69	NUM
eurjchem-1346	426	58	23.56	23.56	NUM
eurjchem-1346	426	59	0.094	0.094	NUM
eurjchem-1346	426	60	0.99	0.99	NUM
eurjchem-1346	426	61	0.78	0.78	NUM
eurjchem-1346	426	62	0.10	0.10	NUM
eurjchem-1346	426	63	3.67	3.67	NUM
eurjchem-1346	426	64	*	*	PUNCT
eurjchem-1346	426	65	6c	6c	NOUN
eurjchem-1346	426	66	4.89	4.89	NUM
eurjchem-1346	426	67	3.45	3.45	NUM
eurjchem-1346	426	68	0.063	0.063	NUM
eurjchem-1346	426	69	0.54	0.54	NUM
eurjchem-1346	426	70	0.75	0.75	NUM
eurjchem-1346	426	71	0.94	0.94	NUM
eurjchem-1346	426	72	*	*	NOUN
eurjchem-1346	426	73	7.80	7.80	NUM
eurjchem-1346	426	74	6d	6d	NUM
eurjchem-1346	426	75	9.08	9.08	NUM
eurjchem-1346	426	76	6.034	6.034	NUM
eurjchem-1346	426	77	0.033	0.033	NUM
eurjchem-1346	426	78	0.37	0.37	NUM
eurjchem-1346	426	79	0.086	0.086	NUM
eurjchem-1346	426	80	0.75	0.75	NUM
eurjchem-1346	426	81	*	*	PUNCT
eurjchem-1346	426	82	23.60	23.60	NUM
eurjchem-1346	426	83	7a	7a	NOUN
eurjchem-1346	426	84	8.18	8.18	NUM
eurjchem-1346	426	85	5.88	5.88	NUM
eurjchem-1346	426	86	0.082	0.082	NUM
eurjchem-1346	426	87	0.65	0.65	NUM
eurjchem-1346	426	88	0.096	0.096	NUM
eurjchem-1346	426	89	0.76	0.76	NUM
eurjchem-1346	426	90	*	*	PUNCT
eurjchem-1346	426	91	14.37	14.37	NUM
eurjchem-1346	426	92	7b	7b	NOUN
eurjchem-1346	426	93	0.065	0.065	NUM
eurjchem-1346	426	94	2.12	2.12	NUM
eurjchem-1346	426	95	0.082	0.082	NUM
eurjchem-1346	426	96	0.47	0.47	NUM
eurjchem-1346	426	97	0.064	0.064	NUM
eurjchem-1346	426	98	0.58	0.58	NUM
eurjchem-1346	426	99	*	*	PUNCT
eurjchem-1346	426	100	16.54	16.54	NUM
eurjchem-1346	426	101	7c	7c	PROPN
eurjchem-1346	426	102	0.0045	0.0045	NUM
eurjchem-1346	426	103	7.13	7.13	NUM
eurjchem-1346	427	1	0.011	0.011	NUM
eurjchem-1346	427	2	0.38	0.38	NUM
eurjchem-1346	427	3	0.085	0.085	NUM
eurjchem-1346	427	4	0.57	0.57	NUM
eurjchem-1346	427	5	*	*	PUNCT
eurjchem-1346	427	6	17.67	17.67	NUM
eurjchem-1346	427	7	sorafenib	sorafenib	NOUN
eurjchem-1346	427	8	0.0034	0.0034	NUM
eurjchem-1346	427	9	0.12	0.12	NUM
eurjchem-1346	427	10	0.17	0.17	NUM
eurjchem-1346	427	11	0.006	0.006	NUM
eurjchem-1346	427	12	0.087	0.087	NUM
eurjchem-1346	427	13	0.61	0.61	NUM
eurjchem-1346	427	14	0.73	0.73	NUM
eurjchem-1346	427	15	0.18	0.18	NUM
eurjchem-1346	427	16	*	*	PUNCT
eurjchem-1346	427	17	inactive	inactive	ADJ
eurjchem-1346	427	18	.	.	PUNCT
eurjchem-1346	427	19	table	table	NOUN
eurjchem-1346	427	20	2	2	NUM
eurjchem-1346	427	21	.	.	PUNCT
eurjchem-1346	428	1	ic50	ic50	PROPN
eurjchem-1346	428	2	(	(	PUNCT
eurjchem-1346	428	3	95	95	NUM
eurjchem-1346	428	4	%	%	NOUN
eurjchem-1346	428	5	confidence	confidence	NOUN
eurjchem-1346	428	6	interval	interval	NOUN
eurjchem-1346	428	7	[	[	X
eurjchem-1346	428	8	nm	nm	NOUN
eurjchem-1346	428	9	]	]	X
eurjchem-1346	428	10	)	)	PUNCT
eurjchem-1346	428	11	of	of	ADP
eurjchem-1346	428	12	tested	test	VERB
eurjchem-1346	428	13	compounds	compound	NOUN
eurjchem-1346	428	14	for	for	ADP
eurjchem-1346	428	15	both	both	DET
eurjchem-1346	428	16	wtbraf	wtbraf	NOUN
eurjchem-1346	428	17	and	and	CCONJ
eurjchem-1346	428	18	v600ebraf	v600ebraf	PROPN
eurjchem-1346	428	19	.	.	PUNCT
eurjchem-1346	429	1	compound	compound	NOUN
eurjchem-1346	429	2	ic50	ic50	PROPN
eurjchem-1346	429	3	(	(	PUNCT
eurjchem-1346	429	4	95	95	NUM
eurjchem-1346	429	5	%	%	NOUN
eurjchem-1346	429	6	confidence	confidence	NOUN
eurjchem-1346	429	7	interval)wtbraf(nm	interval)wtbraf(nm	NOUN
eurjchem-1346	429	8	)	)	PUNCT
eurjchem-1346	429	9	ic50	ic50	PROPN
eurjchem-1346	429	10	(	(	PUNCT
eurjchem-1346	429	11	95	95	NUM
eurjchem-1346	429	12	%	%	NOUN
eurjchem-1346	429	13	confidence	confidence	NOUN
eurjchem-1346	429	14	interval)v600ebraf	interval)v600ebraf	X
eurjchem-1346	429	15	(	(	PUNCT
eurjchem-1346	429	16	nm	nm	NOUN
eurjchem-1346	429	17	)	)	PUNCT
eurjchem-1346	429	18	1	1	NUM
eurjchem-1346	429	19	15.5	15.5	NUM
eurjchem-1346	429	20	0.23	0.23	NUM
eurjchem-1346	429	21	2	2	NUM
eurjchem-1346	429	22	24.4	24.4	NUM
eurjchem-1346	429	23	1.23	1.23	NUM
eurjchem-1346	429	24	3a	3a	NUM
eurjchem-1346	429	25	36.5	36.5	NUM
eurjchem-1346	429	26	0.45	0.45	NUM
eurjchem-1346	429	27	3b	3b	NOUN
eurjchem-1346	429	28	47.6	47.6	NUM
eurjchem-1346	429	29	0.45	0.45	NUM
eurjchem-1346	429	30	3c	3c	NUM
eurjchem-1346	429	31	58.5	58.5	NUM
eurjchem-1346	429	32	1.45	1.45	NUM
eurjchem-1346	429	33	3d	3d	NUM
eurjchem-1346	429	34	84.6	84.6	NUM
eurjchem-1346	429	35	0.44	0.44	NUM
eurjchem-1346	429	36	3e	3e	NOUN
eurjchem-1346	429	37	73.5	73.5	NUM
eurjchem-1346	429	38	0.47	0.47	NUM
eurjchem-1346	429	39	3f	3f	PROPN
eurjchem-1346	430	1	67.6	67.6	NUM
eurjchem-1346	430	2	3.45	3.45	NUM
eurjchem-1346	430	3	3	3	NUM
eurjchem-1346	430	4	g	g	PROPN
eurjchem-1346	430	5	58.7	58.7	NUM
eurjchem-1346	430	6	3.45	3.45	NUM
eurjchem-1346	430	7	3h	3h	NUM
eurjchem-1346	430	8	69.9	69.9	NUM
eurjchem-1346	430	9	0.54	0.54	NUM
eurjchem-1346	430	10	3i	3i	NUM
eurjchem-1346	430	11	78.8	78.8	NUM
eurjchem-1346	430	12	0.65	0.65	NUM
eurjchem-1346	430	13	3j	3j	NOUN
eurjchem-1346	430	14	78.0	78.0	NUM
eurjchem-1346	430	15	6.78	6.78	NUM
eurjchem-1346	430	16	4	4	NUM
eurjchem-1346	430	17	67.0	67.0	NUM
eurjchem-1346	430	18	5.45	5.45	NUM
eurjchem-1346	430	19	5a	5a	NUM
eurjchem-1346	430	20	46.6	46.6	NUM
eurjchem-1346	430	21	0.56	0.56	NUM
eurjchem-1346	430	22	5b	5b	NUM
eurjchem-1346	430	23	55.7	55.7	NUM
eurjchem-1346	430	24	7.45	7.45	NUM
eurjchem-1346	430	25	5c	5c	NUM
eurjchem-1346	430	26	44.5	44.5	NUM
eurjchem-1346	430	27	0.34	0.34	NUM
eurjchem-1346	430	28	5d	5d	NUM
eurjchem-1346	430	29	55.4	55.4	NUM
eurjchem-1346	430	30	0.56	0.56	NUM
eurjchem-1346	430	31	5e	5e	NOUN
eurjchem-1346	430	32	66.5	66.5	NUM
eurjchem-1346	430	33	0.34	0.34	NUM
eurjchem-1346	430	34	6a	6a	NOUN
eurjchem-1346	430	35	77.6	77.6	NUM
eurjchem-1346	430	36	0.31	0.31	NUM
eurjchem-1346	430	37	6b	6b	NOUN
eurjchem-1346	430	38	88.7	88.7	NUM
eurjchem-1346	430	39	0.28	0.28	NUM
eurjchem-1346	430	40	6c	6c	NOUN
eurjchem-1346	430	41	67.5	67.5	NUM
eurjchem-1346	430	42	3.45	3.45	NUM
eurjchem-1346	430	43	6d	6d	NUM
eurjchem-1346	430	44	56.6	56.6	NUM
eurjchem-1346	430	45	7.65	7.65	NUM
eurjchem-1346	430	46	7a	7a	NUM
eurjchem-1346	430	47	45.4	45.4	NUM
eurjchem-1346	430	48	3.27	3.27	NUM
eurjchem-1346	430	49	7b	7b	NUM
eurjchem-1346	430	50	56.5	56.5	NUM
eurjchem-1346	430	51	4.30	4.30	NUM
eurjchem-1346	430	52	7c	7c	NUM
eurjchem-1346	430	53	45.5	45.5	NUM
eurjchem-1346	430	54	4.00	4.00	NUM
eurjchem-1346	430	55	sorafenib	sorafenib	NOUN
eurjchem-1346	430	56	37.8	37.8	NUM
eurjchem-1346	430	57	0.48	0.48	NUM
eurjchem-1346	430	58	furthermore	furthermore	ADV
eurjchem-1346	430	59	,	,	PUNCT
eurjchem-1346	430	60	compounds	compound	NOUN
eurjchem-1346	430	61	5b	5b	NUM
eurjchem-1346	430	62	,	,	PUNCT
eurjchem-1346	430	63	e	e	PRON
eurjchem-1346	430	64	showed	show	VERB
eurjchem-1346	430	65	good	good	ADJ
eurjchem-1346	430	66	activity	activity	NOUN
eurjchem-1346	430	67	(	(	PUNCT
eurjchem-1346	430	68	ic50	ic50	PROPN
eurjchem-1346	430	69	=	=	PROPN
eurjchem-1346	430	70	0.098	0.098	NUM
eurjchem-1346	430	71	and	and	CCONJ
eurjchem-1346	430	72	0.433	0.433	NUM
eurjchem-1346	430	73	μm	μm	NOUN
eurjchem-1346	430	74	,	,	PUNCT
eurjchem-1346	430	75	respectively	respectively	ADV
eurjchem-1346	430	76	)	)	PUNCT
eurjchem-1346	430	77	against	against	ADP
eurjchem-1346	430	78	colon	colon	NOUN
eurjchem-1346	430	79	cell	cell	NOUN
eurjchem-1346	430	80	lines	line	NOUN
eurjchem-1346	431	1	ht29	ht29	PROPN
eurjchem-1346	431	2	(	(	PUNCT
eurjchem-1346	431	3	sorafenib	sorafenib	NOUN
eurjchem-1346	431	4	ic50	ic50	PROPN
eurjchem-1346	431	5	0.73	0.73	NUM
eurjchem-1346	431	6	μm	μm	NUM
eurjchem-1346	431	7	)	)	PUNCT
eurjchem-1346	431	8	.	.	PUNCT
eurjchem-1346	432	1	all	all	DET
eurjchem-1346	432	2	tested	test	VERB
eurjchem-1346	432	3	compounds	compound	NOUN
eurjchem-1346	432	4	exhibited	exhibit	VERB
eurjchem-1346	432	5	high	high	ADJ
eurjchem-1346	432	6	activity	activity	NOUN
eurjchem-1346	432	7	against	against	ADP
eurjchem-1346	432	8	thyroid	thyroid	NOUN
eurjchem-1346	432	9	(	(	PUNCT
eurjchem-1346	432	10	cal62	cal62	PROPN
eurjchem-1346	432	11	,	,	PUNCT
eurjchem-1346	432	12	ftc133	ftc133	PROPN
eurjchem-1346	432	13	,	,	PUNCT
eurjchem-1346	432	14	bcpap	bcpap	NOUN
eurjchem-1346	432	15	and	and	CCONJ
eurjchem-1346	432	16	ml1	ml1	PROPN
eurjchem-1346	432	17	)	)	PUNCT
eurjchem-1346	432	18	cell	cell	NOUN
eurjchem-1346	432	19	lines	line	NOUN
eurjchem-1346	432	20	.	.	PUNCT
eurjchem-1346	433	1	compound	compound	NOUN
eurjchem-1346	433	2	3d	3d	PROPN
eurjchem-1346	433	3	exhibited	exhibit	VERB
eurjchem-1346	433	4	potential	potential	ADJ
eurjchem-1346	433	5	activity	activity	NOUN
eurjchem-1346	433	6	against	against	ADP
eurjchem-1346	433	7	all	all	DET
eurjchem-1346	433	8	tested	test	VERB
eurjchem-1346	433	9	cell	cell	NOUN
eurjchem-1346	433	10	lines	line	NOUN
eurjchem-1346	433	11	.	.	PUNCT
eurjchem-1346	434	1	3.2.2	3.2.2	X
eurjchem-1346	434	2	.	.	PUNCT
eurjchem-1346	434	3	in	in	ADP
eurjchem-1346	434	4	vitro	vitro	X
eurjchem-1346	434	5	kinase	kinase	PROPN
eurjchem-1346	434	6	assay	assay	VERB
eurjchem-1346	434	7	the	the	DET
eurjchem-1346	434	8	in	in	X
eurjchem-1346	434	9	vitro	vitro	X
eurjchem-1346	434	10	kinase	kinase	PROPN
eurjchem-1346	434	11	assay	assay	PROPN
eurjchem-1346	434	12	of	of	ADP
eurjchem-1346	434	13	the	the	DET
eurjchem-1346	434	14	synthesized	synthesize	VERB
eurjchem-1346	434	15	compounds	compound	NOUN
eurjchem-1346	434	16	was	be	AUX
eurjchem-1346	434	17	investigated	investigate	VERB
eurjchem-1346	434	18	against	against	ADP
eurjchem-1346	434	19	both	both	DET
eurjchem-1346	434	20	wtbraf	wtbraf	NOUN
eurjchem-1346	434	21	(	(	PUNCT
eurjchem-1346	434	22	braf	braf	NOUN
eurjchem-1346	434	23	kinase	kinase	PROPN
eurjchem-1346	434	24	wild	wild	ADJ
eurjchem-1346	434	25	type	type	NOUN
eurjchem-1346	434	26	)	)	PUNCT
eurjchem-1346	434	27	and	and	CCONJ
eurjchem-1346	434	28	v600ebraf	v600ebraf	NOUN
eurjchem-1346	434	29	(	(	PUNCT
eurjchem-1346	434	30	mutant	mutant	ADJ
eurjchem-1346	434	31	braf	braf	PROPN
eurjchem-1346	434	32	kinase	kinase	PROPN
eurjchem-1346	434	33	)	)	PUNCT
eurjchem-1346	434	34	(	(	PUNCT
eurjchem-1346	434	35	table	table	NOUN
eurjchem-1346	434	36	2	2	NUM
eurjchem-1346	434	37	)	)	PUNCT
eurjchem-1346	434	38	.	.	PUNCT
eurjchem-1346	435	1	all	all	DET
eurjchem-1346	435	2	compounds	compound	NOUN
eurjchem-1346	435	3	were	be	AUX
eurjchem-1346	435	4	highly	highly	ADV
eurjchem-1346	435	5	active	active	ADJ
eurjchem-1346	435	6	inhibitors	inhibitor	NOUN
eurjchem-1346	435	7	for	for	ADP
eurjchem-1346	435	8	v600ebraf	v600ebraf	NOUN
eurjchem-1346	435	9	(	(	PUNCT
eurjchem-1346	435	10	0.23‐7.65	0.23‐7.65	NOUN
eurjchem-1346	435	11	nm	nm	NOUN
eurjchem-1346	435	12	)	)	PUNCT
eurjchem-1346	435	13	compared	compare	VERB
eurjchem-1346	435	14	with	with	ADP
eurjchem-1346	435	15	moderate	moderate	ADJ
eurjchem-1346	435	16	activity	activity	NOUN
eurjchem-1346	435	17	against	against	ADP
eurjchem-1346	435	18	wtbraf	wtbraf	NOUN
eurjchem-1346	435	19	(	(	PUNCT
eurjchem-1346	435	20	15.5‐88.7	15.5‐88.7	NUM
eurjchem-1346	435	21	nm	nm	NOUN
eurjchem-1346	435	22	)	)	PUNCT
eurjchem-1346	435	23	.	.	PUNCT
eurjchem-1346	436	1	compounds	compound	VERB
eurjchem-1346	436	2	1	1	NUM
eurjchem-1346	436	3	,	,	PUNCT
eurjchem-1346	436	4	3a	3a	NUM
eurjchem-1346	436	5	,	,	PUNCT
eurjchem-1346	436	6	b	b	PROPN
eurjchem-1346	436	7	,	,	PUNCT
eurjchem-1346	436	8	d	d	NOUN
eurjchem-1346	436	9	,	,	PUNCT
eurjchem-1346	436	10	5c	5c	NOUN
eurjchem-1346	436	11	,	,	PUNCT
eurjchem-1346	436	12	e	e	NOUN
eurjchem-1346	436	13	,	,	PUNCT
eurjchem-1346	436	14	and	and	CCONJ
eurjchem-1346	436	15	6a	6a	NOUN
eurjchem-1346	436	16	,	,	PUNCT
eurjchem-1346	436	17	b	b	NUM
eurjchem-1346	436	18	were	be	AUX
eurjchem-1346	436	19	more	more	ADV
eurjchem-1346	436	20	active	active	ADJ
eurjchem-1346	436	21	than	than	ADP
eurjchem-1346	436	22	sorafenib	sorafenib	NOUN
eurjchem-1346	436	23	as	as	SCONJ
eurjchem-1346	436	24	they	they	PRON
eurjchem-1346	436	25	exhibited	exhibit	VERB
eurjchem-1346	436	26	lower	low	ADJ
eurjchem-1346	436	27	ic50	ic50	PROPN
eurjchem-1346	436	28	(	(	PUNCT
eurjchem-1346	436	29	0.23‐0.45	0.23‐0.45	NUM
eurjchem-1346	436	30	nm	nm	NOUN
eurjchem-1346	436	31	)	)	PUNCT
eurjchem-1346	436	32	than	than	ADP
eurjchem-1346	436	33	that	that	PRON
eurjchem-1346	436	34	of	of	ADP
eurjchem-1346	436	35	sorafenib	sorafenib	NOUN
eurjchem-1346	436	36	(	(	PUNCT
eurjchem-1346	436	37	0.48	0.48	NUM
eurjchem-1346	436	38	nm	nm	NOUN
eurjchem-1346	436	39	)	)	PUNCT
eurjchem-1346	436	40	.	.	PUNCT
eurjchem-1346	437	1	compounds	compound	NOUN
eurjchem-1346	437	2	3e	3e	NOUN
eurjchem-1346	437	3	,	,	PUNCT
eurjchem-1346	437	4	h	h	NOUN
eurjchem-1346	437	5	,	,	PUNCT
eurjchem-1346	437	6	i	i	PRON
eurjchem-1346	437	7	,	,	PUNCT
eurjchem-1346	437	8	and	and	CCONJ
eurjchem-1346	437	9	5a	5a	NUM
eurjchem-1346	437	10	,	,	PUNCT
eurjchem-1346	437	11	d	d	PROPN
eurjchem-1346	437	12	had	have	VERB
eurjchem-1346	437	13	comparable	comparable	ADJ
eurjchem-1346	437	14	activity	activity	NOUN
eurjchem-1346	437	15	with	with	ADP
eurjchem-1346	437	16	sorafenib	sorafenib	NOUN
eurjchem-1346	437	17	(	(	PUNCT
eurjchem-1346	437	18	0.47‐0.65	0.47‐0.65	NUM
eurjchem-1346	437	19	nm	nm	NOUN
eurjchem-1346	437	20	)	)	PUNCT
eurjchem-1346	437	21	.	.	PUNCT
eurjchem-1346	438	1	on	on	ADP
eurjchem-1346	438	2	the	the	DET
eurjchem-1346	438	3	other	other	ADJ
eurjchem-1346	438	4	hand	hand	NOUN
eurjchem-1346	438	5	,	,	PUNCT
eurjchem-1346	438	6	compounds	compound	VERB
eurjchem-1346	438	7	2	2	NUM
eurjchem-1346	438	8	,	,	PUNCT
eurjchem-1346	438	9	3c	3c	NUM
eurjchem-1346	438	10	,	,	PUNCT
eurjchem-1346	438	11	f	f	PROPN
eurjchem-1346	438	12	,	,	PUNCT
eurjchem-1346	438	13	g	g	PROPN
eurjchem-1346	438	14	,	,	PUNCT
eurjchem-1346	438	15	j	j	NOUN
eurjchem-1346	438	16	,	,	PUNCT
eurjchem-1346	438	17	4	4	NUM
eurjchem-1346	438	18	,	,	PUNCT
eurjchem-1346	438	19	5b	5b	NUM
eurjchem-1346	438	20	,	,	PUNCT
eurjchem-1346	438	21	6c	6c	NUM
eurjchem-1346	438	22	,	,	PUNCT
eurjchem-1346	438	23	d	d	NOUN
eurjchem-1346	438	24	and	and	CCONJ
eurjchem-1346	438	25	7a‐c	7a‐c	NOUN
eurjchem-1346	438	26	were	be	AUX
eurjchem-1346	438	27	less	less	ADV
eurjchem-1346	438	28	active	active	ADJ
eurjchem-1346	438	29	than	than	ADP
eurjchem-1346	438	30	sorafenib	sorafenib	NOUN
eurjchem-1346	438	31	(	(	PUNCT
eurjchem-1346	438	32	1.23‐7.65	1.23‐7.65	NUM
eurjchem-1346	438	33	nm	nm	NOUN
eurjchem-1346	438	34	)	)	PUNCT
eurjchem-1346	438	35	.	.	PUNCT
eurjchem-1346	439	1	3.3	3.3	NUM
eurjchem-1346	439	2	.	.	PUNCT
eurjchem-1346	440	1	molecular	molecular	ADJ
eurjchem-1346	440	2	docking	docking	NOUN
eurjchem-1346	440	3	braf	braf	NOUN
eurjchem-1346	440	4	is	be	AUX
eurjchem-1346	440	5	isoform	isoform	NOUN
eurjchem-1346	440	6	of	of	ADP
eurjchem-1346	440	7	raf	raf	PROPN
eurjchem-1346	440	8	protein	protein	NOUN
eurjchem-1346	440	9	kinase	kinase	NOUN
eurjchem-1346	440	10	(	(	PUNCT
eurjchem-1346	440	11	rapidly	rapidly	ADV
eurjchem-1346	440	12	accelerated	accelerate	VERB
eurjchem-1346	440	13	fibrosarcoma	fibrosarcoma	ADV
eurjchem-1346	440	14	)	)	PUNCT
eurjchem-1346	440	15	,	,	PUNCT
eurjchem-1346	440	16	that	that	PRON
eurjchem-1346	440	17	was	be	AUX
eurjchem-1346	440	18	known	know	VERB
eurjchem-1346	440	19	at	at	ADP
eurjchem-1346	440	20	1988	1988	NUM
eurjchem-1346	440	21	.	.	PUNCT
eurjchem-1346	441	1	braf	braf	NOUN
eurjchem-1346	441	2	proteins	protein	NOUN
eurjchem-1346	441	3	are	be	AUX
eurjchem-1346	441	4	encoded	encode	VERB
eurjchem-1346	441	5	by	by	ADP
eurjchem-1346	441	6	raf	raf	PROPN
eurjchem-1346	441	7	oncogenes	oncogene	NOUN
eurjchem-1346	441	8	which	which	PRON
eurjchem-1346	441	9	are	be	AUX
eurjchem-1346	441	10	located	locate	VERB
eurjchem-1346	441	11	in	in	ADP
eurjchem-1346	441	12	chromosome	chromosome	NOUN
eurjchem-1346	441	13	7q32	7q32	NOUN
eurjchem-1346	441	14	.	.	PUNCT
eurjchem-1346	442	1	braf	braf	NOUN
eurjchem-1346	442	2	is	be	AUX
eurjchem-1346	442	3	a	a	DET
eurjchem-1346	442	4	serine	serine	NOUN
eurjchem-1346	442	5	/	/	SYM
eurjchem-1346	442	6	threonine	threonine	ADJ
eurjchem-1346	442	7	specific	specific	ADJ
eurjchem-1346	442	8	protein	protein	NOUN
eurjchem-1346	442	9	kinase	kinase	NOUN
eurjchem-1346	442	10	that	that	PRON
eurjchem-1346	442	11	has	have	AUX
eurjchem-1346	442	12	long	long	ADV
eurjchem-1346	442	13	been	be	AUX
eurjchem-1346	442	14	viewed	view	VERB
eurjchem-1346	442	15	as	as	ADP
eurjchem-1346	442	16	key	key	ADJ
eurjchem-1346	442	17	players	player	NOUN
eurjchem-1346	442	18	in	in	ADP
eurjchem-1346	442	19	the	the	DET
eurjchem-1346	442	20	mapk	mapk	NOUN
eurjchem-1346	442	21	pathway	pathway	NOUN
eurjchem-1346	442	22	.	.	PUNCT
eurjchem-1346	443	1	under	under	ADP
eurjchem-1346	443	2	normal	normal	ADJ
eurjchem-1346	443	3	circumstances	circumstance	NOUN
eurjchem-1346	443	4	,	,	PUNCT
eurjchem-1346	443	5	braf	braf	NOUN
eurjchem-1346	443	6	is	be	AUX
eurjchem-1346	443	7	activated	activate	VERB
eurjchem-1346	443	8	in	in	ADP
eurjchem-1346	443	9	a	a	DET
eurjchem-1346	443	10	ras	ras	X
eurjchem-1346	443	11	small	small	ADJ
eurjchem-1346	443	12	g‐protein	g‐protein	CCONJ
eurjchem-1346	443	13	dependent	dependent	ADJ
eurjchem-1346	443	14	manner	manner	NOUN
eurjchem-1346	443	15	.	.	PUNCT
eurjchem-1346	444	1	it	it	PRON
eurjchem-1346	444	2	then	then	ADV
eurjchem-1346	444	3	phosphorylates	phosphorylate	VERB
eurjchem-1346	444	4	and	and	CCONJ
eurjchem-1346	444	5	activates	activate	VERB
eurjchem-1346	444	6	the	the	DET
eurjchem-1346	444	7	protein	protein	NOUN
eurjchem-1346	444	8	kinase	kinase	PROPN
eurjchem-1346	444	9	mek	mek	PROPN
eurjchem-1346	444	10	and	and	CCONJ
eurjchem-1346	444	11	erk	erk	PROPN
eurjchem-1346	444	12	orderly	orderly	ADV
eurjchem-1346	444	13	,	,	PUNCT
eurjchem-1346	444	14	regulating	regulate	VERB
eurjchem-1346	444	15	gene	gene	NOUN
eurjchem-1346	444	16	expression	expression	NOUN
eurjchem-1346	444	17	and	and	CCONJ
eurjchem-1346	444	18	controlling	control	VERB
eurjchem-1346	444	19	how	how	SCONJ
eurjchem-1346	444	20	cells	cell	NOUN
eurjchem-1346	444	21	respond	respond	VERB
eurjchem-1346	444	22	to	to	ADP
eurjchem-1346	444	23	extracellular	extracellular	ADJ
eurjchem-1346	444	24	signals	signal	NOUN
eurjchem-1346	444	25	.	.	PUNCT
eurjchem-1346	445	1	braf	braf	PROPN
eurjchem-1346	445	2	kinase	kinase	PROPN
eurjchem-1346	445	3	domain	domain	PROPN
eurjchem-1346	445	4	consists	consist	VERB
eurjchem-1346	445	5	of	of	ADP
eurjchem-1346	445	6	two	two	NUM
eurjchem-1346	445	7	lobes	lobe	NOUN
eurjchem-1346	445	8	,	,	PUNCT
eurjchem-1346	445	9	small	small	ADJ
eurjchem-1346	445	10	n‐	n‐	NOUN
eurjchem-1346	445	11	terminal	terminal	PROPN
eurjchem-1346	445	12	lobe	lobe	VERB
eurjchem-1346	445	13	and	and	CCONJ
eurjchem-1346	445	14	large	large	ADJ
eurjchem-1346	445	15	c‐terminal	c‐terminal	ADJ
eurjchem-1346	445	16	lobe	lobe	NOUN
eurjchem-1346	445	17	.	.	PUNCT
eurjchem-1346	446	1	the	the	DET
eurjchem-1346	446	2	small	small	ADJ
eurjchem-1346	446	3	n‐terminal	n‐terminal	PROPN
eurjchem-1346	446	4	lobe	lobe	PROPN
eurjchem-1346	446	5	has	have	AUX
eurjchem-1346	446	6	antiparallel	antiparallel	ADJ
eurjchem-1346	446	7	β‐sheet	β‐sheet	NUM
eurjchem-1346	446	8	structure	structure	NOUN
eurjchem-1346	446	9	which	which	DET
eurjchem-1346	446	10	anchors	anchor	NOUN
eurjchem-1346	446	11	and	and	CCONJ
eurjchem-1346	446	12	orients	orient	VERB
eurjchem-1346	446	13	atp	atp	NOUN
eurjchem-1346	446	14	molecule	molecule	NOUN
eurjchem-1346	446	15	.	.	PUNCT
eurjchem-1346	447	1	the	the	DET
eurjchem-1346	447	2	large	large	ADJ
eurjchem-1346	447	3	c‐terminal	c‐terminal	ADJ
eurjchem-1346	447	4	lobe	lobe	NOUN
eurjchem-1346	447	5	is	be	AUX
eurjchem-1346	447	6	mainly	mainly	ADV
eurjchem-1346	447	7	α‐	α‐	NUM
eurjchem-1346	447	8	helical	helical	ADJ
eurjchem-1346	447	9	which	which	PRON
eurjchem-1346	447	10	binds	bind	VERB
eurjchem-1346	447	11	to	to	ADP
eurjchem-1346	447	12	mek	mek	PROPN
eurjchem-1346	447	13	as	as	ADP
eurjchem-1346	447	14	a	a	DET
eurjchem-1346	447	15	protein	protein	NOUN
eurjchem-1346	447	16	substrate	substrate	NOUN
eurjchem-1346	447	17	.	.	PUNCT
eurjchem-1346	448	1	moreove	moreove	NOUN
eurjchem-1346	448	2	phosphate‐b	phosphate‐b	NOUN
eurjchem-1346	448	3	these	these	DET
eurjchem-1346	448	4	two	two	NUM
eurjchem-1346	448	5	lo	lo	PROPN
eurjchem-1346	448	6	inhibitors	inhibitor	NOUN
eurjchem-1346	449	1	[	[	X
eurjchem-1346	449	2	3	3	NUM
eurjchem-1346	449	3	in	in	ADP
eurjchem-1346	449	4	each	each	DET
eurjchem-1346	449	5	segment	segment	NOUN
eurjchem-1346	449	6	is	be	AUX
eurjchem-1346	449	7	lo	lo	PROPN
eurjchem-1346	449	8	mations	mation	NOUN
eurjchem-1346	449	9	.	.	PUNCT
eurjchem-1346	450	1	in	in	ADP
eurjchem-1346	450	2	t	t	PROPN
eurjchem-1346	450	3	αc‐helix	αc‐helix	PROPN
eurjchem-1346	450	4	rota	rota	NOUN
eurjchem-1346	450	5	on	on	ADP
eurjchem-1346	450	6	the	the	DET
eurjchem-1346	450	7	othe	othe	ADJ
eurjchem-1346	450	8	terminal	terminal	ADJ
eurjchem-1346	450	9	lob	lob	NOUN
eurjchem-1346	450	10	sequences	sequence	NOUN
eurjchem-1346	450	11	an	an	PRON
eurjchem-1346	450	12	in	in	ADP
eurjchem-1346	450	13	the	the	DET
eurjchem-1346	450	14	inactiv	inactiv	ADV
eurjchem-1346	450	15	the	the	DET
eurjchem-1346	450	16	phenylal	phenylal	NOUN
eurjchem-1346	450	17	(	(	PUNCT
eurjchem-1346	450	18	dfg	dfg	PROPN
eurjchem-1346	450	19	asp‐ou	asp‐ou	PROPN
eurjchem-1346	450	20	the	the	DET
eurjchem-1346	450	21	phenylal	phenylal	PROPN
eurjchem-1346	450	22	chains	chain	NOUN
eurjchem-1346	450	23	expos	expos	NOUN
eurjchem-1346	450	24	most	most	ADJ
eurjchem-1346	450	25	br	br	NOUN
eurjchem-1346	450	26	segment	segment	NOUN
eurjchem-1346	450	27	(	(	PUNCT
eurjchem-1346	450	28	p‐	p‐	PROPN
eurjchem-1346	450	29	active	active	ADJ
eurjchem-1346	450	30	state	state	NOUN
eurjchem-1346	450	31	mutation	mutation	NOUN
eurjchem-1346	450	32	(	(	PUNCT
eurjchem-1346	450	33	va	va	NOUN
eurjchem-1346	450	34	approximate	approximate	NOUN
eurjchem-1346	450	35	as	as	ADP
eurjchem-1346	450	36	v600ebraf	v600ebraf	NOUN
eurjchem-1346	450	37	the	the	DET
eurjchem-1346	450	38	x‐ra	x‐ra	NOUN
eurjchem-1346	450	39	(	(	PUNCT
eurjchem-1346	450	40	native	native	ADJ
eurjchem-1346	450	41	ligan	ligan	NOUN
eurjchem-1346	451	1	[	[	X
eurjchem-1346	451	2	2,3‐b]pyridi	2,3‐b]pyridi	PROPN
eurjchem-1346	451	3	code	code	NOUN
eurjchem-1346	451	4	:	:	PUNCT
eurjchem-1346	451	5	4fk3	4fk3	NUM
eurjchem-1346	451	6	)	)	PUNCT
eurjchem-1346	451	7	with	with	ADP
eurjchem-1346	451	8	binding	bind	VERB
eurjchem-1346	451	9	kinase	kinase	NOUN
eurjchem-1346	451	10	.	.	PUNCT
eurjchem-1346	452	1	the	the	DET
eurjchem-1346	452	2	rearrangeme	rearrangeme	NOUN
eurjchem-1346	452	3	movement	movement	NOUN
eurjchem-1346	452	4	o	o	NOUN
eurjchem-1346	452	5	hydrophobic	hydrophobic	NOUN
eurjchem-1346	452	6	movement	movement	NOUN
eurjchem-1346	452	7	re	re	ADP
eurjchem-1346	452	8	to	to	ADP
eurjchem-1346	452	9	atp	atp	PROPN
eurjchem-1346	452	10	bindi	bindi	PROPN
eurjchem-1346	452	11	which	which	PRON
eurjchem-1346	452	12	the	the	DET
eurjchem-1346	452	13	a	a	DET
eurjchem-1346	452	14	bonding	bonding	NOUN
eurjchem-1346	452	15	inte	inte	NOUN
eurjchem-1346	452	16	which	which	PRON
eurjchem-1346	452	17	is	be	AUX
eurjchem-1346	452	18	nece	nece	X
eurjchem-1346	452	19	binding	bind	VERB
eurjchem-1346	452	20	site	site	NOUN
eurjchem-1346	452	21	a	a	DET
eurjchem-1346	452	22	the	the	DET
eurjchem-1346	452	23	bind	bind	NOUN
eurjchem-1346	452	24	energy	energy	NOUN
eurjchem-1346	452	25	score	score	NOUN
eurjchem-1346	452	26	indicates	indicate	VERB
eurjchem-1346	452	27	goo	goo	NOUN
eurjchem-1346	452	28	cation	cation	NOUN
eurjchem-1346	452	29	intera	intera	NOUN
eurjchem-1346	452	30	the	the	DET
eurjchem-1346	452	31	results	result	NOUN
eurjchem-1346	452	32	kinase	kinase	PROPN
eurjchem-1346	452	33	prot	prot	NOUN
eurjchem-1346	452	34	moieties	moiety	NOUN
eurjchem-1346	452	35	and	and	CCONJ
eurjchem-1346	452	36	and	and	CCONJ
eurjchem-1346	452	37	plx3203	plx3203	ADJ
eurjchem-1346	452	38	fig	fig	NOUN
eurjchem-1346	452	39	analysis	analysis	NOUN
eurjchem-1346	452	40	(	(	PUNCT
eurjchem-1346	452	41	i	i	NOUN
eurjchem-1346	452	42	)	)	PUNCT
eurjchem-1346	452	43	the	the	DET
eurjchem-1346	452	44	reproduced	reproduce	VERB
eurjchem-1346	452	45	b	b	NOUN
eurjchem-1346	452	46	root	root	NOUN
eurjchem-1346	452	47	mean	mean	NOUN
eurjchem-1346	452	48	s	s	PART
eurjchem-1346	452	49	(	(	PUNCT
eurjchem-1346	452	50	‐19.2870	‐19.2870	NOUN
eurjchem-1346	452	51	k	k	PROPN
eurjchem-1346	452	52	protocol	protocol	PROPN
eurjchem-1346	452	53	wa	wa	INTJ
eurjchem-1346	452	54	forming	form	VERB
eurjchem-1346	452	55	two	two	NUM
eurjchem-1346	452	56	er	er	INTJ
eurjchem-1346	452	57	,	,	PUNCT
eurjchem-1346	452	58	it	it	PRON
eurjchem-1346	452	59	contain	contain	VERB
eurjchem-1346	452	60	binding	binding	ADJ
eurjchem-1346	452	61	loop	loop	NOUN
eurjchem-1346	452	62	)	)	PUNCT
eurjchem-1346	452	63	.	.	PUNCT
eurjchem-1346	453	1	t	t	PROPN
eurjchem-1346	453	2	obes	obe	VERB
eurjchem-1346	453	3	that	that	SCONJ
eurjchem-1346	453	4	wer	wer	NOUN
eurjchem-1346	453	5	3	3	NUM
eurjchem-1346	453	6	]	]	PUNCT
eurjchem-1346	453	7	.	.	PUNCT
eurjchem-1346	454	1	lobe	lobe	PROPN
eurjchem-1346	454	2	(	(	PUNCT
eurjchem-1346	454	3	n	n	NOUN
eurjchem-1346	454	4	and	and	CCONJ
eurjchem-1346	454	5	ocated	ocate	VERB
eurjchem-1346	454	6	which	which	DET
eurjchem-1346	454	7	h	h	NOUN
eurjchem-1346	454	8	the	the	DET
eurjchem-1346	454	9	small	small	ADJ
eurjchem-1346	454	10	n‐term	n‐term	NOUN
eurjchem-1346	454	11	ates	ate	NOUN
eurjchem-1346	454	12	and	and	CCONJ
eurjchem-1346	454	13	makes	make	VERB
eurjchem-1346	454	14	er	er	INTJ
eurjchem-1346	454	15	hand	hand	NOUN
eurjchem-1346	454	16	,	,	PUNCT
eurjchem-1346	454	17	this	this	PRON
eurjchem-1346	454	18	a	a	DET
eurjchem-1346	454	19	be	be	NOUN
eurjchem-1346	454	20	begins	begin	VERB
eurjchem-1346	454	21	with	with	ADP
eurjchem-1346	454	22	nd	nd	PRON
eurjchem-1346	454	23	adjusted	adjust	VERB
eurjchem-1346	454	24	to	to	ADP
eurjchem-1346	454	25	ve	ve	VERB
eurjchem-1346	454	26	conformatio	conformatio	PROPN
eurjchem-1346	454	27	anine	anine	NOUN
eurjchem-1346	454	28	side	side	NOUN
eurjchem-1346	454	29	chai	chai	NOUN
eurjchem-1346	454	30	ut	ut	PROPN
eurjchem-1346	454	31	conformation	conformation	PROPN
eurjchem-1346	454	32	anine	anine	PROPN
eurjchem-1346	454	33	side	side	NOUN
eurjchem-1346	454	34	chai	chai	NOUN
eurjchem-1346	454	35	sed	se	VERB
eurjchem-1346	454	36	into	into	ADP
eurjchem-1346	454	37	the	the	DET
eurjchem-1346	454	38	bin	bin	PROPN
eurjchem-1346	454	39	raf	raf	PROPN
eurjchem-1346	454	40	kinase	kinase	PROPN
eurjchem-1346	454	41	m	m	PROPN
eurjchem-1346	454	42	‐loop	‐loop	PROPN
eurjchem-1346	454	43	)	)	PUNCT
eurjchem-1346	454	44	.	.	PUNCT
eurjchem-1346	455	1	these	these	PRON
eurjchem-1346	455	2	m	m	VERB
eurjchem-1346	455	3	rather	rather	ADV
eurjchem-1346	455	4	than	than	ADP
eurjchem-1346	455	5	t	t	PROPN
eurjchem-1346	455	6	al	al	PROPN
eurjchem-1346	455	7	600	600	NUM
eurjchem-1346	455	8	is	be	AUX
eurjchem-1346	455	9	replace	replace	NOUN
eurjchem-1346	455	10	ely	ely	ADV
eurjchem-1346	455	11	90	90	NUM
eurjchem-1346	455	12	%	%	NOUN
eurjchem-1346	455	13	of	of	ADP
eurjchem-1346	455	14	kno	kno	PROPN
eurjchem-1346	455	15	f	f	PROPN
eurjchem-1346	455	16	kinase	kinase	PROPN
eurjchem-1346	456	1	[	[	X
eurjchem-1346	456	2	33	33	NUM
eurjchem-1346	456	3	]	]	PUNCT
eurjchem-1346	456	4	.	.	PUNCT
eurjchem-1346	457	1	ay	ay	PROPN
eurjchem-1346	457	2	crystal	crystal	PROPN
eurjchem-1346	457	3	stru	stru	PROPN
eurjchem-1346	457	4	nd	nd	PRON
eurjchem-1346	457	5	)	)	PUNCT
eurjchem-1346	457	6	,	,	PUNCT
eurjchem-1346	457	7	n‐{2,4‐difl	n‐{2,4‐difl	PROPN
eurjchem-1346	457	8	in‐3‐yl)carbony	in‐3‐yl)carbony	NUM
eurjchem-1346	457	9	[	[	X
eurjchem-1346	457	10	28	28	NUM
eurjchem-1346	457	11	]	]	PUNCT
eurjchem-1346	457	12	shows	show	VERB
eurjchem-1346	457	13	th	th	PRON
eurjchem-1346	457	14	g	g	NOUN
eurjchem-1346	457	15	to	to	ADP
eurjchem-1346	457	16	the	the	DET
eurjchem-1346	457	17	dfg‐o	dfg‐o	PUNCT
eurjchem-1346	457	18	allosteric	allosteric	ADJ
eurjchem-1346	457	19	bind	bind	NOUN
eurjchem-1346	457	20	ent	ent	NOUN
eurjchem-1346	457	21	of	of	ADP
eurjchem-1346	457	22	the	the	DET
eurjchem-1346	457	23	a	a	NOUN
eurjchem-1346	457	24	of	of	ADP
eurjchem-1346	457	25	a	a	DET
eurjchem-1346	457	26	phenylala	phenylala	NOUN
eurjchem-1346	457	27	c	c	NOUN
eurjchem-1346	457	28	pocket	pocket	NOUN
eurjchem-1346	457	29	and	and	CCONJ
eurjchem-1346	457	30	esults	esult	NOUN
eurjchem-1346	457	31	in	in	ADP
eurjchem-1346	457	32	a	a	DET
eurjchem-1346	457	33	conf	conf	NOUN
eurjchem-1346	457	34	ing	ing	NOUN
eurjchem-1346	457	35	and	and	CCONJ
eurjchem-1346	457	36	also	also	ADV
eurjchem-1346	457	37	cre	cre	PROPN
eurjchem-1346	457	38	allosteric	allosteric	PROPN
eurjchem-1346	457	39	kinas	kinas	PROPN
eurjchem-1346	457	40	eractions	eraction	NOUN
eurjchem-1346	457	41	with	with	ADP
eurjchem-1346	457	42	essary	essary	ADJ
eurjchem-1346	457	43	for	for	ADP
eurjchem-1346	457	44	tight	tight	ADJ
eurjchem-1346	457	45	and	and	CCONJ
eurjchem-1346	457	46	is	be	AUX
eurjchem-1346	457	47	present	present	ADJ
eurjchem-1346	457	48	i	i	PRON
eurjchem-1346	457	49	ding	de	VERB
eurjchem-1346	457	50	affinity	affinity	NOUN
eurjchem-1346	457	51	o	o	NOUN
eurjchem-1346	457	52	e	e	X
eurjchem-1346	457	53	(	(	PUNCT
eurjchem-1346	457	54	s	s	PROPN
eurjchem-1346	457	55	,	,	PUNCT
eurjchem-1346	457	56	kcal	kcal	PROPN
eurjchem-1346	457	57	/	/	SYM
eurjchem-1346	457	58	mol	mol	NOUN
eurjchem-1346	457	59	)	)	PUNCT
eurjchem-1346	457	60	od	od	NOUN
eurjchem-1346	457	61	affinity	affinity	NOUN
eurjchem-1346	457	62	.	.	PUNCT
eurjchem-1346	458	1	hyd	hyd	NOUN
eurjchem-1346	458	2	action	action	NOUN
eurjchem-1346	458	3	were	be	AUX
eurjchem-1346	458	4	also	also	ADV
eurjchem-1346	458	5	of	of	ADP
eurjchem-1346	458	6	docking	docking	NOUN
eurjchem-1346	458	7	stud	stud	NOUN
eurjchem-1346	458	8	tein	tein	PROPN
eurjchem-1346	458	9	active	active	ADJ
eurjchem-1346	458	10	sit	sit	NOUN
eurjchem-1346	458	11	d	d	NOUN
eurjchem-1346	458	12	hydrogen	hydrogen	PROPN
eurjchem-1346	458	13	bon	bon	X
eurjchem-1346	458	14	3	3	NUM
eurjchem-1346	458	15	(	(	PUNCT
eurjchem-1346	458	16	figure	figure	NOUN
eurjchem-1346	458	17	2	2	NUM
eurjchem-1346	458	18	)	)	PUNCT
eurjchem-1346	458	19	.	.	PUNCT
eurjchem-1346	459	1	gure	gure	NOUN
eurjchem-1346	459	2	2	2	NUM
eurjchem-1346	459	3	.	.	PUNCT
eurjchem-1346	459	4	2d	2d	PROPN
eurjchem-1346	459	5	interac	interac	NOUN
eurjchem-1346	459	6	of	of	ADP
eurjchem-1346	459	7	the	the	DET
eurjchem-1346	459	8	docking	docking	NOUN
eurjchem-1346	459	9	plx3203‐(v60	plx3203‐(v60	NOUN
eurjchem-1346	459	10	by	by	ADP
eurjchem-1346	459	11	the	the	DET
eurjchem-1346	459	12	docking	docking	NOUN
eurjchem-1346	459	13	square	square	ADJ
eurjchem-1346	459	14	deviatio	deviatio	PROPN
eurjchem-1346	459	15	kcal	kcal	PROPN
eurjchem-1346	459	16	/	/	SYM
eurjchem-1346	459	17	mol	mol	PROPN
eurjchem-1346	459	18	,	,	PUNCT
eurjchem-1346	459	19	table	table	NOUN
eurjchem-1346	459	20	as	as	ADP
eurjchem-1346	459	21	valid	valid	ADJ
eurjchem-1346	459	22	.	.	PUNCT
eurjchem-1346	460	1	plx32	plx32	PROPN
eurjchem-1346	460	2	hydrogen	hydrogen	PROPN
eurjchem-1346	460	3	bon	bon	PROPN
eurjchem-1346	460	4	amin	amin	PROPN
eurjchem-1346	460	5	et	et	PROPN
eurjchem-1346	460	6	al	al	PROPN
eurjchem-1346	460	7	ns	ns	PROPN
eurjchem-1346	460	8	a	a	DET
eurjchem-1346	460	9	p‐loop	p‐loop	NOUN
eurjchem-1346	460	10	the	the	DET
eurjchem-1346	460	11	catalytic	catalytic	ADJ
eurjchem-1346	460	12	sit	sit	NOUN
eurjchem-1346	460	13	e	e	NOUN
eurjchem-1346	460	14	occupied	occupy	VERB
eurjchem-1346	460	15	by	by	ADP
eurjchem-1346	460	16	c‐terminal	c‐terminal	PROPN
eurjchem-1346	460	17	lo	lo	PROPN
eurjchem-1346	460	18	has	have	VERB
eurjchem-1346	460	19	both	both	CCONJ
eurjchem-1346	460	20	active	active	ADJ
eurjchem-1346	460	21	minal	minal	ADJ
eurjchem-1346	460	22	lobe	lobe	NOUN
eurjchem-1346	460	23	,	,	PUNCT
eurjchem-1346	460	24	a	a	DET
eurjchem-1346	460	25	se	se	X
eurjchem-1346	460	26	part	part	NOUN
eurjchem-1346	460	27	of	of	ADP
eurjchem-1346	460	28	the	the	DET
eurjchem-1346	460	29	acti	acti	ADJ
eurjchem-1346	460	30	activation	activation	NOUN
eurjchem-1346	460	31	segm	segm	VERB
eurjchem-1346	460	32	a	a	DET
eurjchem-1346	460	33	dfg	dfg	NOUN
eurjchem-1346	460	34	(	(	PUNCT
eurjchem-1346	460	35	asp	asp	PROPN
eurjchem-1346	460	36	/	/	SYM
eurjchem-1346	460	37	p	p	NOUN
eurjchem-1346	460	38	make	make	VERB
eurjchem-1346	460	39	part	part	NOUN
eurjchem-1346	460	40	of	of	ADP
eurjchem-1346	460	41	t	t	PROPN
eurjchem-1346	460	42	on	on	ADP
eurjchem-1346	460	43	of	of	ADP
eurjchem-1346	460	44	this	this	DET
eurjchem-1346	460	45	segme	segme	NOUN
eurjchem-1346	460	46	n	n	PRON
eurjchem-1346	460	47	exposed	expose	VERB
eurjchem-1346	460	48	away	away	ADV
eurjchem-1346	460	49	n	n	CCONJ
eurjchem-1346	460	50	)	)	PUNCT
eurjchem-1346	460	51	,	,	PUNCT
eurjchem-1346	460	52	while	while	SCONJ
eurjchem-1346	460	53	in	in	ADP
eurjchem-1346	460	54	the	the	DET
eurjchem-1346	460	55	n	n	NOUN
eurjchem-1346	460	56	rotates	rotate	VERB
eurjchem-1346	460	57	out	out	ADP
eurjchem-1346	460	58	an	an	DET
eurjchem-1346	460	59	ding	ding	NOUN
eurjchem-1346	460	60	sit	sit	NOUN
eurjchem-1346	461	1	[	[	X
eurjchem-1346	461	2	33	33	NUM
eurjchem-1346	461	3	]	]	PUNCT
eurjchem-1346	461	4	.	.	PUNCT
eurjchem-1346	462	1	mutations	mutation	NOUN
eurjchem-1346	462	2	occu	occu	VERB
eurjchem-1346	462	3	mutations	mutation	NOUN
eurjchem-1346	462	4	keep	keep	VERB
eurjchem-1346	462	5	the	the	DET
eurjchem-1346	462	6	inactive	inactive	ADJ
eurjchem-1346	462	7	st	st	PROPN
eurjchem-1346	462	8	ed	ed	NOUN
eurjchem-1346	462	9	by	by	ADP
eurjchem-1346	462	10	glu	glu	NOUN
eurjchem-1346	462	11	in	in	ADP
eurjchem-1346	462	12	the	the	DET
eurjchem-1346	462	13	own	own	ADJ
eurjchem-1346	462	14	braf	braf	NOUN
eurjchem-1346	462	15	mut	mut	NOUN
eurjchem-1346	462	16	ucture	ucture	NOUN
eurjchem-1346	462	17	of	of	ADP
eurjchem-1346	462	18	braf	braf	NOUN
eurjchem-1346	462	19	luoro‐3‐[(5‐pyr	luoro‐3‐[(5‐pyr	ADJ
eurjchem-1346	462	20	yl]phenyl}ethan	yl]phenyl}ethan	ADJ
eurjchem-1346	462	21	hat	hat	NOUN
eurjchem-1346	462	22	it	it	PRON
eurjchem-1346	462	23	exists	exist	VERB
eurjchem-1346	462	24	m	m	VERB
eurjchem-1346	462	25	out	out	ADV
eurjchem-1346	462	26	allosteric	allosteric	ADJ
eurjchem-1346	462	27	p	p	NOUN
eurjchem-1346	462	28	ding	ding	NOUN
eurjchem-1346	462	29	site	site	NOUN
eurjchem-1346	462	30	is	be	AUX
eurjchem-1346	462	31	m	m	NOUN
eurjchem-1346	462	32	activation	activation	NOUN
eurjchem-1346	462	33	loop	loop	NOUN
eurjchem-1346	462	34	anine	anine	NOUN
eurjchem-1346	462	35	side	side	NOUN
eurjchem-1346	462	36	ch	ch	NOUN
eurjchem-1346	462	37	into	into	ADP
eurjchem-1346	462	38	the	the	DET
eurjchem-1346	462	39	atp	atp	NOUN
eurjchem-1346	462	40	formation	formation	NOUN
eurjchem-1346	462	41	that	that	PRON
eurjchem-1346	462	42	i	i	PRON
eurjchem-1346	462	43	eates	eat	VERB
eurjchem-1346	462	44	a	a	DET
eurjchem-1346	462	45	large	large	ADJ
eurjchem-1346	462	46	hy	hy	NOUN
eurjchem-1346	462	47	se	se	X
eurjchem-1346	462	48	inhibitors	inhibitor	NOUN
eurjchem-1346	462	49	b	b	PROPN
eurjchem-1346	462	50	cys532	cys532	PROPN
eurjchem-1346	462	51	in	in	ADP
eurjchem-1346	462	52	the	the	DET
eurjchem-1346	462	53	t	t	NOUN
eurjchem-1346	462	54	binding	binding	NOUN
eurjchem-1346	462	55	of	of	ADP
eurjchem-1346	462	56	the	the	PRON
eurjchem-1346	462	57	in	in	ADP
eurjchem-1346	462	58	most	most	ADJ
eurjchem-1346	462	59	braf	braf	NOUN
eurjchem-1346	462	60	in	in	ADP
eurjchem-1346	462	61	of	of	ADP
eurjchem-1346	462	62	the	the	DET
eurjchem-1346	462	63	ligand	ligand	NOUN
eurjchem-1346	462	64	w	w	PROPN
eurjchem-1346	462	65	(	(	PUNCT
eurjchem-1346	462	66	table	table	NOUN
eurjchem-1346	462	67	3	3	NUM
eurjchem-1346	462	68	)	)	PUNCT
eurjchem-1346	462	69	.	.	PUNCT
eurjchem-1346	463	1	low	low	PROPN
eurjchem-1346	463	2	drogen	drogen	PROPN
eurjchem-1346	463	3	bond	bond	NOUN
eurjchem-1346	463	4	,	,	PUNCT
eurjchem-1346	463	5	ar	ar	NOUN
eurjchem-1346	463	6	o	o	PROPN
eurjchem-1346	463	7	used	use	VERB
eurjchem-1346	463	8	to	to	PART
eurjchem-1346	463	9	assess	assess	VERB
eurjchem-1346	463	10	dy	dy	NOUN
eurjchem-1346	463	11	;	;	PUNCT
eurjchem-1346	463	12	dock	dock	NOUN
eurjchem-1346	463	13	score	score	NOUN
eurjchem-1346	463	14	te	te	ADP
eurjchem-1346	463	15	amino	amino	NOUN
eurjchem-1346	463	16	acid	acid	PROPN
eurjchem-1346	463	17	nd	nd	AUX
eurjchem-1346	463	18	length	length	NOUN
eurjchem-1346	463	19	for	for	ADP
eurjchem-1346	463	20	ea	ea	NOUN
eurjchem-1346	463	21	ction	ction	NOUN
eurjchem-1346	463	22	of	of	ADP
eurjchem-1346	463	23	plx3203w	plx3203w	NOUN
eurjchem-1346	463	24	results	result	NOUN
eurjchem-1346	463	25	reveale	reveale	NOUN
eurjchem-1346	463	26	00ebraf	00ebraf	NOUN
eurjchem-1346	463	27	)	)	PUNCT
eurjchem-1346	463	28	comp	comp	NOUN
eurjchem-1346	463	29	procedure	procedure	NOUN
eurjchem-1346	463	30	as	as	ADP
eurjchem-1346	463	31	d	d	PROPN
eurjchem-1346	463	32	on	on	ADP
eurjchem-1346	463	33	,	,	PUNCT
eurjchem-1346	463	34	rmsd	rmsd	X
eurjchem-1346	463	35	(	(	PUNCT
eurjchem-1346	463	36	1.21	1.21	NUM
eurjchem-1346	463	37	e	e	NOUN
eurjchem-1346	463	38	3	3	NUM
eurjchem-1346	463	39	)	)	PUNCT
eurjchem-1346	463	40	,	,	PUNCT
eurjchem-1346	463	41	achieved	achieve	VERB
eurjchem-1346	463	42	203	203	NUM
eurjchem-1346	463	43	nearly	nearly	ADV
eurjchem-1346	463	44	fits	fit	VERB
eurjchem-1346	463	45	ding	ding	NOUN
eurjchem-1346	463	46	interactio	interactio	NOUN
eurjchem-1346	463	47	l.	l.	PROPN
eurjchem-1346	463	48	/	/	SYM
eurjchem-1346	463	49	european	european	PROPN
eurjchem-1346	463	50	jou	jou	INTJ
eurjchem-1346	463	51	(	(	PUNCT
eurjchem-1346	463	52	glycine‐rich	glycine‐rich	NOUN
eurjchem-1346	463	53	te	te	PROPN
eurjchem-1346	463	54	is	be	AUX
eurjchem-1346	463	55	located	locate	VERB
eurjchem-1346	463	56	bet	bet	NOUN
eurjchem-1346	463	57	y	y	PROPN
eurjchem-1346	463	58	most	most	ADV
eurjchem-1346	463	59	braf	braf	PROPN
eurjchem-1346	463	60	k	k	PROPN
eurjchem-1346	463	61	bes	bes	PROPN
eurjchem-1346	463	62	)	)	PUNCT
eurjchem-1346	463	63	,	,	PUNCT
eurjchem-1346	463	64	a	a	DET
eurjchem-1346	463	65	polype	polype	NOUN
eurjchem-1346	463	66	and	and	CCONJ
eurjchem-1346	463	67	inactive	inactive	ADJ
eurjchem-1346	463	68	co	co	NOUN
eurjchem-1346	463	69	egment	egment	NOUN
eurjchem-1346	463	70	designa	designa	PROPN
eurjchem-1346	464	1	i	i	PRON
eurjchem-1346	464	2	ve	ve	VERB
eurjchem-1346	464	3	atp‐	atp‐	NOUN
eurjchem-1346	464	4	bindin	bindin	NOUN
eurjchem-1346	464	5	ment	ment	NOUN
eurjchem-1346	464	6	in	in	ADP
eurjchem-1346	464	7	the	the	DET
eurjchem-1346	464	8	lar	lar	PROPN
eurjchem-1346	464	9	phe	phe	PROPN
eurjchem-1346	464	10	/	/	SYM
eurjchem-1346	464	11	gly	gly	NOUN
eurjchem-1346	464	12	)	)	PUNCT
eurjchem-1346	464	13	amino	amino	NOUN
eurjchem-1346	464	14	the	the	DET
eurjchem-1346	464	15	atp‐bindin	atp‐bindin	NOUN
eurjchem-1346	464	16	ent	ent	NOUN
eurjchem-1346	464	17	in	in	ADP
eurjchem-1346	464	18	the	the	DET
eurjchem-1346	464	19	large	large	ADJ
eurjchem-1346	464	20	y	y	PROPN
eurjchem-1346	464	21	from	from	ADP
eurjchem-1346	464	22	the	the	DET
eurjchem-1346	464	23	activ	activ	PROPN
eurjchem-1346	464	24	active	active	ADJ
eurjchem-1346	464	25	conform	conform	NOUN
eurjchem-1346	464	26	nd	nd	ADP
eurjchem-1346	464	27	the	the	DET
eurjchem-1346	464	28	aspartat	aspartat	ADJ
eurjchem-1346	464	29	r	r	NOUN
eurjchem-1346	464	30	in	in	ADP
eurjchem-1346	464	31	the	the	DET
eurjchem-1346	464	32	activ	activ	NOUN
eurjchem-1346	464	33	p	p	PROPN
eurjchem-1346	464	34	the	the	DET
eurjchem-1346	464	35	p‐loop	p‐loop	NOUN
eurjchem-1346	464	36	i	i	PRON
eurjchem-1346	464	37	tate	tate	VERB
eurjchem-1346	464	38	.	.	PUNCT
eurjchem-1346	465	1	the	the	DET
eurjchem-1346	465	2	val6	val6	PROPN
eurjchem-1346	465	3	p‐loop	p‐loop	NOUN
eurjchem-1346	465	4	)	)	PUNCT
eurjchem-1346	465	5	accoun	accoun	PROPN
eurjchem-1346	465	6	ations	ation	NOUN
eurjchem-1346	465	7	which	which	PRON
eurjchem-1346	465	8	k	k	PROPN
eurjchem-1346	465	9	f	f	PROPN
eurjchem-1346	465	10	with	with	ADP
eurjchem-1346	465	11	its	its	PRON
eurjchem-1346	465	12	plx	plx	PROPN
eurjchem-1346	465	13	ridin‐3‐yl‐1h‐py	ridin‐3‐yl‐1h‐py	PROPN
eurjchem-1346	465	14	nesulfonamide	nesulfonamide	NOUN
eurjchem-1346	465	15	(	(	PUNCT
eurjchem-1346	465	16	mainly	mainly	ADV
eurjchem-1346	465	17	in	in	ADP
eurjchem-1346	465	18	dimer	dimer	NOUN
eurjchem-1346	465	19	pocket	pocket	NOUN
eurjchem-1346	465	20	of	of	ADP
eurjchem-1346	465	21	v600e	v600e	PROPN
eurjchem-1346	465	22	ade	ade	INTJ
eurjchem-1346	465	23	accessible	accessible	ADJ
eurjchem-1346	465	24	p	p	NOUN
eurjchem-1346	465	25	and	and	CCONJ
eurjchem-1346	465	26	subse	subse	VERB
eurjchem-1346	465	27	ain	ain	NOUN
eurjchem-1346	465	28	out	out	ADP
eurjchem-1346	465	29	of	of	ADP
eurjchem-1346	465	30	a	a	DET
eurjchem-1346	465	31	p	p	NOUN
eurjchem-1346	465	32	binding	bind	VERB
eurjchem-1346	465	33	site	site	NOUN
eurjchem-1346	465	34	.	.	PUNCT
eurjchem-1346	466	1	is	be	AUX
eurjchem-1346	466	2	mutually	mutually	ADV
eurjchem-1346	466	3	exc	exc	VERB
eurjchem-1346	466	4	ydrophobic	ydrophobic	NOUN
eurjchem-1346	466	5	poc	poc	NOUN
eurjchem-1346	466	6	bind	bind	VERB
eurjchem-1346	466	7	.	.	PUNCT
eurjchem-1346	467	1	in	in	ADP
eurjchem-1346	467	2	additio	additio	PROPN
eurjchem-1346	467	3	atp	atp	PROPN
eurjchem-1346	467	4	binding	bind	VERB
eurjchem-1346	467	5	p	p	NOUN
eurjchem-1346	467	6	inhibitor	inhibitor	NOUN
eurjchem-1346	467	7	in	in	ADP
eurjchem-1346	467	8	the	the	DET
eurjchem-1346	467	9	nhibitors	nhibitor	NOUN
eurjchem-1346	467	10	[	[	X
eurjchem-1346	467	11	34	34	NUM
eurjchem-1346	467	12	]	]	PUNCT
eurjchem-1346	467	13	.	.	PUNCT
eurjchem-1346	468	1	was	be	AUX
eurjchem-1346	468	2	evaluated	evaluate	VERB
eurjchem-1346	468	3	w	w	ADP
eurjchem-1346	468	4	dock	dock	NOUN
eurjchem-1346	468	5	score	score	NOUN
eurjchem-1346	468	6	e	e	PROPN
eurjchem-1346	468	7	rene	rene	NOUN
eurjchem-1346	468	8	arene	arene	NOUN
eurjchem-1346	468	9	and	and	CCONJ
eurjchem-1346	468	10	s	s	VERB
eurjchem-1346	468	11	the	the	DET
eurjchem-1346	468	12	binding	bind	VERB
eurjchem-1346	468	13	m	m	PRON
eurjchem-1346	468	14	,	,	PUNCT
eurjchem-1346	468	15	involved	involve	VERB
eurjchem-1346	468	16	v600e	v600e	PROPN
eurjchem-1346	468	17	d	d	PROPN
eurjchem-1346	468	18	interacting	interact	VERB
eurjchem-1346	468	19	l	l	NOUN
eurjchem-1346	468	20	ach	ach	PROPN
eurjchem-1346	468	21	active	active	ADJ
eurjchem-1346	468	22	comp	comp	NOUN
eurjchem-1346	468	23	ith	ith	PROPN
eurjchem-1346	468	24	v600ebraf	v600ebraf	PROPN
eurjchem-1346	468	25	.	.	PUNCT
eurjchem-1346	469	1	ed	ed	NOUN
eurjchem-1346	470	1	that	that	PRON
eurjchem-1346	470	2	:	:	PUNCT
eurjchem-1346	470	3	plex	plex	PROPN
eurjchem-1346	470	4	was	be	AUX
eurjchem-1346	470	5	pre	pre	AUX
eurjchem-1346	470	6	demonstrated	demonstrate	VERB
eurjchem-1346	470	7	b	b	NOUN
eurjchem-1346	470	8	173	173	NUM
eurjchem-1346	470	9	)	)	PUNCT
eurjchem-1346	470	10	and	and	CCONJ
eurjchem-1346	470	11	dock	dock	NOUN
eurjchem-1346	470	12	d	d	PROPN
eurjchem-1346	470	13	that	that	SCONJ
eurjchem-1346	470	14	the	the	DET
eurjchem-1346	470	15	do	do	NOUN
eurjchem-1346	470	16	s	s	X
eurjchem-1346	470	17	in	in	ADP
eurjchem-1346	470	18	the	the	DET
eurjchem-1346	470	19	activ	activ	NOUN
eurjchem-1346	470	20	ns	n	VERB
eurjchem-1346	470	21	with	with	ADP
eurjchem-1346	470	22	cys	cys	PROPN
eurjchem-1346	470	23	53	53	NUM
eurjchem-1346	470	24	urnal	urnal	NOUN
eurjchem-1346	470	25	of	of	ADP
eurjchem-1346	470	26	chemistr	chemistr	PROPN
eurjchem-1346	470	27	atp‐	atp‐	PROPN
eurjchem-1346	470	28	tween	tween	NOUN
eurjchem-1346	470	29	kinase	kinase	PROPN
eurjchem-1346	470	30	eptide	eptide	ADV
eurjchem-1346	470	31	onfor‐	onfor‐	PROPN
eurjchem-1346	470	32	ted	te	VERB
eurjchem-1346	470	33	as	as	ADP
eurjchem-1346	470	34	ng	ng	PROPN
eurjchem-1346	470	35	site	site	NOUN
eurjchem-1346	470	36	.	.	PUNCT
eurjchem-1346	471	1	rge	rge	PROPN
eurjchem-1346	471	2	c‐	c‐	PROPN
eurjchem-1346	471	3	o	o	X
eurjchem-1346	471	4	acid	acid	NOUN
eurjchem-1346	471	5	g	g	PROPN
eurjchem-1346	471	6	site	site	NOUN
eurjchem-1346	471	7	.	.	PUNCT
eurjchem-1346	472	1	e	e	NOUN
eurjchem-1346	472	2	lobe	lobe	VERB
eurjchem-1346	472	3	,	,	PUNCT
eurjchem-1346	472	4	ve	ve	VERB
eurjchem-1346	472	5	site	site	NOUN
eurjchem-1346	472	6	mation	mation	PROPN
eurjchem-1346	472	7	,	,	PUNCT
eurjchem-1346	472	8	te	te	ADP
eurjchem-1346	472	9	side	side	NOUN
eurjchem-1346	472	10	vation	vation	NOUN
eurjchem-1346	472	11	in	in	ADP
eurjchem-1346	472	12	the	the	DET
eurjchem-1346	472	13	00glu	00glu	NOUN
eurjchem-1346	472	14	nts	nt	NOUN
eurjchem-1346	472	15	for	for	ADP
eurjchem-1346	472	16	known	know	VERB
eurjchem-1346	472	17	x3203	x3203	PROPN
eurjchem-1346	472	18	yrrolo	yrrolo	PROPN
eurjchem-1346	472	19	(	(	PUNCT
eurjchem-1346	472	20	pdb	pdb	NOUN
eurjchem-1346	472	21	r	r	NOUN
eurjchem-1346	472	22	form	form	NOUN
eurjchem-1346	472	23	ebraf	ebraf	NOUN
eurjchem-1346	472	24	by	by	ADP
eurjchem-1346	472	25	a	a	DET
eurjchem-1346	472	26	equent	equent	ADJ
eurjchem-1346	472	27	large	large	ADJ
eurjchem-1346	472	28	.	.	PUNCT
eurjchem-1346	473	1	this	this	DET
eurjchem-1346	473	2	clusive	clusive	ADJ
eurjchem-1346	473	3	cket	cket	NOUN
eurjchem-1346	473	4	to	to	AUX
eurjchem-1346	473	5	on	on	ADP
eurjchem-1346	473	6	,	,	PUNCT
eurjchem-1346	473	7	h‐	h‐	NOUN
eurjchem-1346	473	8	pocket	pocket	NOUN
eurjchem-1346	473	9	e	e	NOUN
eurjchem-1346	473	10	atp‐	atp‐	NOUN
eurjchem-1346	473	11	d	d	PROPN
eurjchem-1346	473	12	with	with	ADP
eurjchem-1346	473	13	energy	energy	NOUN
eurjchem-1346	473	14	arene	arene	NOUN
eurjchem-1346	473	15	models	model	NOUN
eurjchem-1346	473	16	.	.	PUNCT
eurjchem-1346	474	1	ebraf	ebraf	NOUN
eurjchem-1346	474	2	ligand	ligand	VERB
eurjchem-1346	474	3	pound	pound	NOUN
eurjchem-1346	474	4	ecisely	ecisely	ADV
eurjchem-1346	474	5	by	by	ADP
eurjchem-1346	474	6	low	low	ADJ
eurjchem-1346	474	7	score	score	NOUN
eurjchem-1346	474	8	ocking	ocking	NOUN
eurjchem-1346	474	9	e	e	NOUN
eurjchem-1346	474	10	site	site	NOUN
eurjchem-1346	474	11	32	32	NUM
eurjchem-1346	474	12	and	and	CCONJ
eurjchem-1346	474	13	phe	phe	PROPN
eurjchem-1346	474	14	531	531	NUM
eurjchem-1346	474	15	enz	enz	NOUN
eurjchem-1346	474	16	fits	fit	VERB
eurjchem-1346	474	17	and	and	CCONJ
eurjchem-1346	474	18	ran	run	VERB
eurjchem-1346	474	19	one	one	NUM
eurjchem-1346	474	20	cati	cati	PROPN
eurjchem-1346	474	21	com	com	NOUN
eurjchem-1346	474	22	acti	acti	VERB
eurjchem-1346	474	23	‐14	‐14	X
eurjchem-1346	475	1	583	583	NUM
eurjchem-1346	475	2	invo	invo	NOUN
eurjchem-1346	475	3	‐19	‐19	PROPN
eurjchem-1346	475	4	com	com	NOUN
eurjchem-1346	475	5	to	to	PART
eurjchem-1346	475	6	mor	mor	PROPN
eurjchem-1346	475	7	‐17	‐17	PROPN
eurjchem-1346	475	8	com	com	PROPN
eurjchem-1346	475	9	kca	kca	PROPN
eurjchem-1346	475	10	kca	kca	PROPN
eurjchem-1346	475	11	with	with	ADP
eurjchem-1346	475	12	inte	inte	PROPN
eurjchem-1346	475	13	lys	lys	PROPN
eurjchem-1346	475	14	nm	nm	PROPN
eurjchem-1346	475	15	)	)	PUNCT
eurjchem-1346	475	16	with	with	ADP
eurjchem-1346	475	17	one	one	NUM
eurjchem-1346	475	18	seco	seco	NOUN
eurjchem-1346	475	19	and	and	CCONJ
eurjchem-1346	475	20	to	to	ADP
eurjchem-1346	475	21	a	a	PRON
eurjchem-1346	475	22	and	and	CCONJ
eurjchem-1346	475	23	4	4	NUM
eurjchem-1346	475	24	.	.	X
eurjchem-1346	476	1	c	c	PROPN
eurjchem-1346	476	2	syn	syn	PROPN
eurjchem-1346	476	3	acti	acti	PROPN
eurjchem-1346	476	4	line	line	NOUN
eurjchem-1346	476	5	ry	ry	PROPN
eurjchem-1346	476	6	7	7	NUM
eurjchem-1346	476	7	(	(	PUNCT
eurjchem-1346	476	8	1	1	NUM
eurjchem-1346	476	9	)	)	PUNCT
eurjchem-1346	476	10	(	(	PUNCT
eurjchem-1346	476	11	2016	2016	NUM
eurjchem-1346	476	12	)	)	PUNCT
eurjchem-1346	476	13	1	1	NUM
eurjchem-1346	476	14	e	e	NOUN
eurjchem-1346	476	15	595	595	NUM
eurjchem-1346	476	16	,	,	PUNCT
eurjchem-1346	476	17	three	three	NUM
eurjchem-1346	476	18	are	be	AUX
eurjchem-1346	476	19	1	1	NUM
eurjchem-1346	476	20	and	and	CCONJ
eurjchem-1346	476	21	one	one	NUM
eurjchem-1346	476	22	arene	arene	NOUN
eurjchem-1346	476	23	(	(	PUNCT
eurjchem-1346	476	24	ii	ii	NOUN
eurjchem-1346	476	25	)	)	PUNCT
eurjchem-1346	476	26	the	the	DET
eurjchem-1346	476	27	docki	docki	NOUN
eurjchem-1346	476	28	zyme	zyme	PROPN
eurjchem-1346	476	29	inhibition	inhibition	NOUN
eurjchem-1346	476	30	in	in	ADP
eurjchem-1346	476	31	the	the	DET
eurjchem-1346	476	32	active	active	ADJ
eurjchem-1346	477	1	si	si	NOUN
eurjchem-1346	477	2	d	d	PRON
eurjchem-1346	477	3	one	one	NUM
eurjchem-1346	477	4	arene	arene	NOUN
eurjchem-1346	477	5	aren	aren	AUX
eurjchem-1346	477	6	figure	figure	VERB
eurjchem-1346	477	7	3	3	NUM
eurjchem-1346	477	8	.	.	PUNCT
eurjchem-1346	478	1	(	(	PUNCT
eurjchem-1346	478	2	iii	iii	X
eurjchem-1346	478	3	)	)	PUNCT
eurjchem-1346	478	4	the	the	DET
eurjchem-1346	478	5	dockin	dockin	PROPN
eurjchem-1346	478	6	ge	ge	PROPN
eurjchem-1346	478	7	‐10.6210	‐10.6210	PROPN
eurjchem-1346	478	8	to	to	ADP
eurjchem-1346	478	9	e	e	PROPN
eurjchem-1346	478	10	or	or	CCONJ
eurjchem-1346	478	11	two	two	NUM
eurjchem-1346	478	12	hydro	hydro	NOUN
eurjchem-1346	478	13	ion	ion	NOUN
eurjchem-1346	478	14	interactions	interaction	NOUN
eurjchem-1346	478	15	mpounds	mpound	VERB
eurjchem-1346	478	16	3j	3j	NUM
eurjchem-1346	479	1	an	an	PRON
eurjchem-1346	480	1	i	i	PROPN
eurjchem-1346	480	2	ve	ve	VERB
eurjchem-1346	480	3	site	site	NOUN
eurjchem-1346	480	4	altho	altho	PROPN
eurjchem-1346	480	5	.6555	.6555	PROPN
eurjchem-1346	480	6	respectiv	respectiv	PROPN
eurjchem-1346	480	7	3	3	PROPN
eurjchem-1346	480	8	,	,	PUNCT
eurjchem-1346	480	9	asp	asp	PROPN
eurjchem-1346	480	10	594	594	NUM
eurjchem-1346	480	11	an	an	DET
eurjchem-1346	480	12	olved	olve	VERB
eurjchem-1346	480	13	in	in	ADP
eurjchem-1346	480	14	these	these	PRON
eurjchem-1346	480	15	i	i	PRON
eurjchem-1346	480	16	(	(	PUNCT
eurjchem-1346	480	17	iv	iv	X
eurjchem-1346	480	18	)	)	PUNCT
eurjchem-1346	480	19	the	the	DET
eurjchem-1346	480	20	docki	docki	NOUN
eurjchem-1346	480	21	.0422	.0422	PROPN
eurjchem-1346	481	1	kcal	kcal	PROPN
eurjchem-1346	481	2	/	/	SYM
eurjchem-1346	481	3	mo	mo	PROPN
eurjchem-1346	481	4	mpounds	mpound	NOUN
eurjchem-1346	481	5	5a‐e	5a‐e	PROPN
eurjchem-1346	481	6	s	s	VERB
eurjchem-1346	481	7	‐21.0419	‐21.0419	NOUN
eurjchem-1346	481	8	kcal/	kcal/	NUM
eurjchem-1346	481	9	reover	reover	ADV
eurjchem-1346	481	10	,	,	PUNCT
eurjchem-1346	481	11	the	the	DET
eurjchem-1346	481	12	doc	doc	PROPN
eurjchem-1346	481	13	.4771	.4771	PROPN
eurjchem-1346	481	14	kcal	kcal	PROPN
eurjchem-1346	481	15	/	/	SYM
eurjchem-1346	481	16	mo	mo	PROPN
eurjchem-1346	481	17	mpounds	mpounds	PROPN
eurjchem-1346	481	18	7a‐c	7a‐c	PROPN
eurjchem-1346	481	19	s	s	PROPN
eurjchem-1346	481	20	al	al	PROPN
eurjchem-1346	481	21	/	/	SYM
eurjchem-1346	481	22	mol	mol	PROPN
eurjchem-1346	481	23	and	and	CCONJ
eurjchem-1346	481	24	ic50	ic50	PROPN
eurjchem-1346	481	25	(	(	PUNCT
eurjchem-1346	481	26	v	v	NOUN
eurjchem-1346	481	27	)	)	PUNCT
eurjchem-1346	481	28	compoun	compoun	PROPN
eurjchem-1346	481	29	al	al	PROPN
eurjchem-1346	481	30	/	/	SYM
eurjchem-1346	481	31	mol	mol	PROPN
eurjchem-1346	481	32	)	)	PUNCT
eurjchem-1346	481	33	and	and	CCONJ
eurjchem-1346	481	34	bin	bin	PROPN
eurjchem-1346	481	35	h	h	PROPN
eurjchem-1346	481	36	asp	asp	PROPN
eurjchem-1346	481	37	594	594	NUM
eurjchem-1346	481	38	an	an	DET
eurjchem-1346	481	39	eraction	eraction	NOUN
eurjchem-1346	481	40	with	with	ADP
eurjchem-1346	481	41	tr	tr	PRON
eurjchem-1346	481	42	483	483	NUM
eurjchem-1346	481	43	(	(	PUNCT
eurjchem-1346	481	44	figure	figure	NOUN
eurjchem-1346	481	45	4	4	NUM
eurjchem-1346	481	46	)	)	PUNCT
eurjchem-1346	481	47	figure	figure	NOUN
eurjchem-1346	481	48	4	4	NUM
eurjchem-1346	481	49	.	.	PUNCT
eurjchem-1346	481	50	2d	2d	PROPN
eurjchem-1346	481	51	compound	compound	NOUN
eurjchem-1346	481	52	1	1	NUM
eurjchem-1346	481	53	,	,	PUNCT
eurjchem-1346	481	54	)	)	PUNCT
eurjchem-1346	481	55	while	while	SCONJ
eurjchem-1346	481	56	gave	give	VERB
eurjchem-1346	481	57	a	a	DET
eurjchem-1346	481	58	d	d	NOUN
eurjchem-1346	481	59	h	h	NOUN
eurjchem-1346	481	60	the	the	DET
eurjchem-1346	481	61	active	active	ADJ
eurjchem-1346	481	62	sit	sit	NOUN
eurjchem-1346	481	63	e	e	NOUN
eurjchem-1346	481	64	arene	arene	NOUN
eurjchem-1346	481	65	arene	arene	NOUN
eurjchem-1346	481	66	ond	ond	NOUN
eurjchem-1346	481	67	most	most	ADJ
eurjchem-1346	481	68	activ	activ	PROPN
eurjchem-1346	481	69	d	d	PROPN
eurjchem-1346	481	70	showed	show	VERB
eurjchem-1346	481	71	a	a	DET
eurjchem-1346	481	72	doc	doc	PROPN
eurjchem-1346	481	73	active	active	ADJ
eurjchem-1346	481	74	site	site	NOUN
eurjchem-1346	481	75	with	with	ADP
eurjchem-1346	481	76	d	d	PROPN
eurjchem-1346	481	77	one	one	NUM
eurjchem-1346	481	78	arene	arene	NOUN
eurjchem-1346	481	79	cati	cati	NOUN
eurjchem-1346	481	80	conclusion	conclusion	VERB
eurjchem-1346	481	81	a	a	DET
eurjchem-1346	481	82	number	number	NOUN
eurjchem-1346	481	83	of	of	ADP
eurjchem-1346	481	84	nthesized	nthesize	VERB
eurjchem-1346	481	85	.	.	PUNCT
eurjchem-1346	482	1	most	most	ADJ
eurjchem-1346	482	2	ivity	ivity	NOUN
eurjchem-1346	482	3	towards	towards	ADP
eurjchem-1346	482	4	th	th	NUM
eurjchem-1346	482	5	es	es	NOUN
eurjchem-1346	482	6	.	.	PUNCT
eurjchem-1346	483	1	compound	compound	NOUN
eurjchem-1346	483	2	3	3	NUM
eurjchem-1346	483	3	9‐29	9‐29	NUM
eurjchem-1346	483	4	ene	ene	NOUN
eurjchem-1346	483	5	arene	arene	NOUN
eurjchem-1346	483	6	inter	inter	NOUN
eurjchem-1346	483	7	e	e	PROPN
eurjchem-1346	483	8	cation	cation	NOUN
eurjchem-1346	483	9	interact	interact	VERB
eurjchem-1346	483	10	ing	ing	ADJ
eurjchem-1346	483	11	score	score	NOUN
eurjchem-1346	483	12	for	for	ADP
eurjchem-1346	483	13	s	s	PRON
eurjchem-1346	483	14	n	n	PRON
eurjchem-1346	483	15	assay	assay	NOUN
eurjchem-1346	483	16	)	)	PUNCT
eurjchem-1346	483	17	was	be	AUX
eurjchem-1346	483	18	‐	‐	ADJ
eurjchem-1346	483	19	ite	ite	NOUN
eurjchem-1346	483	20	forming	form	VERB
eurjchem-1346	483	21	one	one	NUM
eurjchem-1346	483	22	ne	ne	NOUN
eurjchem-1346	483	23	interaction	interaction	NOUN
eurjchem-1346	483	24	w	w	PROPN
eurjchem-1346	483	25	2d	2d	PROPN
eurjchem-1346	483	26	interaction	interaction	NOUN
eurjchem-1346	483	27	of	of	ADP
eurjchem-1346	483	28	s	s	NOUN
eurjchem-1346	483	29	ng	ng	PROPN
eurjchem-1346	483	30	score	score	NOUN
eurjchem-1346	483	31	of	of	ADP
eurjchem-1346	483	32	test	test	NOUN
eurjchem-1346	483	33	‐21.0419	‐21.0419	PROPN
eurjchem-1346	483	34	kcal	kcal	PROPN
eurjchem-1346	483	35	ogen	ogen	PROPN
eurjchem-1346	483	36	bonds	bond	VERB
eurjchem-1346	483	37	an	an	DET
eurjchem-1346	483	38	s	s	NOUN
eurjchem-1346	483	39	with	with	ADP
eurjchem-1346	483	40	the	the	DET
eurjchem-1346	483	41	enzy	enzy	NOUN
eurjchem-1346	483	42	nd	nd	NOUN
eurjchem-1346	483	43	7a	7a	NUM
eurjchem-1346	483	44	showed	show	VERB
eurjchem-1346	483	45	ugh	ugh	NOUN
eurjchem-1346	483	46	binding	bind	VERB
eurjchem-1346	483	47	vely	vely	ADV
eurjchem-1346	483	48	.	.	PUNCT
eurjchem-1346	484	1	lys	lys	PROPN
eurjchem-1346	484	2	483	483	NUM
eurjchem-1346	484	3	,	,	PUNCT
eurjchem-1346	484	4	t	t	PROPN
eurjchem-1346	484	5	nd	nd	PRON
eurjchem-1346	484	6	phe	phe	PROPN
eurjchem-1346	484	7	595	595	NUM
eurjchem-1346	484	8	a	a	DET
eurjchem-1346	484	9	nteractions	nteraction	NOUN
eurjchem-1346	484	10	.	.	PUNCT
eurjchem-1346	485	1	ing	ing	ADJ
eurjchem-1346	485	2	scores	score	NOUN
eurjchem-1346	485	3	of	of	ADP
eurjchem-1346	485	4	c	c	NOUN
eurjchem-1346	485	5	ol	ol	ADJ
eurjchem-1346	485	6	)	)	PUNCT
eurjchem-1346	485	7	with	with	ADP
eurjchem-1346	485	8	ic50	ic50	PROPN
eurjchem-1346	485	9	showed	show	VERB
eurjchem-1346	485	10	docking	docking	NOUN
eurjchem-1346	485	11	/mol	/mol	PUNCT
eurjchem-1346	486	1	while	while	SCONJ
eurjchem-1346	486	2	th	th	X
eurjchem-1346	486	3	cking	cke	VERB
eurjchem-1346	486	4	scores	score	NOUN
eurjchem-1346	486	5	of	of	ADP
eurjchem-1346	486	6	c	c	NOUN
eurjchem-1346	486	7	ol	ol	PROPN
eurjchem-1346	486	8	)	)	PUNCT
eurjchem-1346	486	9	,	,	PUNCT
eurjchem-1346	486	10	with	with	ADP
eurjchem-1346	486	11	ic50	ic50	PROPN
eurjchem-1346	486	12	(	(	PUNCT
eurjchem-1346	486	13	0	0	X
eurjchem-1346	486	14	.	.	PROPN
eurjchem-1346	486	15	showed	show	VERB
eurjchem-1346	486	16	docking	dock	VERB
eurjchem-1346	486	17	3.27‐4.30	3.27‐4.30	NUM
eurjchem-1346	486	18	nm	nm	NOUN
eurjchem-1346	486	19	.	.	PUNCT
eurjchem-1346	487	1	d	d	X
eurjchem-1346	487	2	5dgave	5dgave	PROPN
eurjchem-1346	487	3	bes	bes	PROPN
eurjchem-1346	487	4	nds	nd	NOUN
eurjchem-1346	487	5	with	with	ADP
eurjchem-1346	487	6	2	2	NUM
eurjchem-1346	487	7	hydr	hydr	NOUN
eurjchem-1346	487	8	nd	nd	NOUN
eurjchem-1346	487	9	lys	lys	NOUN
eurjchem-1346	487	10	483	483	NUM
eurjchem-1346	487	11	re	re	NOUN
eurjchem-1346	487	12	rp	rp	ADP
eurjchem-1346	487	13	531	531	NUM
eurjchem-1346	487	14	and	and	CCONJ
eurjchem-1346	487	15	one	one	NUM
eurjchem-1346	487	16	)	)	PUNCT
eurjchem-1346	487	17	.	.	PUNCT
eurjchem-1346	488	1	d	d	PRON
eurjchem-1346	488	2	interaction	interaction	NOUN
eurjchem-1346	488	3	of	of	ADP
eurjchem-1346	488	4	com	com	NOUN
eurjchem-1346	488	5	most	most	ADV
eurjchem-1346	488	6	active	active	ADJ
eurjchem-1346	488	7	co	co	NOUN
eurjchem-1346	488	8	docking	dock	VERB
eurjchem-1346	488	9	score	score	NOUN
eurjchem-1346	488	10	o	o	NOUN
eurjchem-1346	488	11	e	e	NOUN
eurjchem-1346	488	12	with	with	ADP
eurjchem-1346	488	13	one	one	NUM
eurjchem-1346	488	14	hyd	hyd	NOUN
eurjchem-1346	488	15	interaction	interaction	NOUN
eurjchem-1346	488	16	wi	wi	PROPN
eurjchem-1346	488	17	ve	ve	AUX
eurjchem-1346	488	18	compound	compound	VERB
eurjchem-1346	488	19	e	e	NOUN
eurjchem-1346	488	20	cking	cke	VERB
eurjchem-1346	488	21	score	score	NOUN
eurjchem-1346	488	22	of	of	ADP
eurjchem-1346	488	23	‐1	‐1	NUM
eurjchem-1346	488	24	h	h	NOUN
eurjchem-1346	488	25	one	one	NUM
eurjchem-1346	488	26	arene	arene	NOUN
eurjchem-1346	488	27	ate	eat	VERB
eurjchem-1346	488	28	ion	ion	NOUN
eurjchem-1346	488	29	interaction	interaction	NOUN
eurjchem-1346	488	30	w	w	PROPN
eurjchem-1346	488	31	f	f	PROPN
eurjchem-1346	488	32	new	new	ADJ
eurjchem-1346	488	33	pyridop	pyridop	PROPN
eurjchem-1346	488	34	t	t	PROPN
eurjchem-1346	488	35	of	of	ADP
eurjchem-1346	488	36	these	these	DET
eurjchem-1346	488	37	com	com	NOUN
eurjchem-1346	488	38	hyroid	hyroid	PROPN
eurjchem-1346	488	39	cell	cell	NOUN
eurjchem-1346	488	40	lines	line	NOUN
eurjchem-1346	488	41	3d	3d	PROPN
eurjchem-1346	488	42	was	be	AUX
eurjchem-1346	488	43	the	the	DET
eurjchem-1346	488	44	most	most	ADJ
eurjchem-1346	488	45	actions	action	NOUN
eurjchem-1346	488	46	with	with	ADP
eurjchem-1346	488	47	ph	ph	ADJ
eurjchem-1346	488	48	tion	tion	NOUN
eurjchem-1346	488	49	with	with	ADP
eurjchem-1346	488	50	lys	lys	PROPN
eurjchem-1346	488	51	48	48	NUM
eurjchem-1346	488	52	sorafenib	sorafenib	NOUN
eurjchem-1346	488	53	(	(	PUNCT
eurjchem-1346	488	54	stan	stan	PROPN
eurjchem-1346	488	55	23.4155	23.4155	NUM
eurjchem-1346	488	56	kcal/	kcal/	NUM
eurjchem-1346	488	57	hydrogen	hydrogen	NOUN
eurjchem-1346	488	58	bond	bond	NOUN
eurjchem-1346	488	59	with	with	ADP
eurjchem-1346	488	60	phe	phe	PROPN
eurjchem-1346	488	61	583	583	NUM
eurjchem-1346	488	62	(	(	PUNCT
eurjchem-1346	488	63	f	f	PROPN
eurjchem-1346	488	64	sorafenib	sorafenib	NOUN
eurjchem-1346	488	65	with	with	ADP
eurjchem-1346	488	66	v600	v600	PROPN
eurjchem-1346	488	67	ted	te	VERB
eurjchem-1346	488	68	compounds	compound	NOUN
eurjchem-1346	488	69	/mol	/mol	PROPN
eurjchem-1346	488	70	.	.	PUNCT
eurjchem-1346	489	1	all	all	DET
eurjchem-1346	489	2	comp	comp	NOUN
eurjchem-1346	489	3	nd/	nd/	PROPN
eurjchem-1346	489	4	or	or	CCONJ
eurjchem-1346	489	5	arene	arene	VERB
eurjchem-1346	489	6	a	a	DET
eurjchem-1346	489	7	yme	yme	NOUN
eurjchem-1346	489	8	active	active	ADJ
eurjchem-1346	489	9	site	site	NOUN
eurjchem-1346	489	10	no	no	DET
eurjchem-1346	489	11	binding	bind	VERB
eurjchem-1346	489	12	in	in	ADP
eurjchem-1346	489	13	scores	score	NOUN
eurjchem-1346	489	14	were	be	AUX
eurjchem-1346	489	15	trp	trp	PROPN
eurjchem-1346	489	16	531	531	NUM
eurjchem-1346	489	17	,	,	PUNCT
eurjchem-1346	489	18	cys	cys	PROPN
eurjchem-1346	489	19	53	53	NUM
eurjchem-1346	489	20	re	re	NOUN
eurjchem-1346	489	21	the	the	DET
eurjchem-1346	489	22	amino	amino	NOUN
eurjchem-1346	489	23	compounds	compound	NOUN
eurjchem-1346	489	24	3a‐	3a‐	NUM
eurjchem-1346	489	25	(	(	PUNCT
eurjchem-1346	489	26	0.44‐6.78	0.44‐6.78	PROPN
eurjchem-1346	489	27	nm	nm	PUNCT
eurjchem-1346	489	28	g	g	NOUN
eurjchem-1346	489	29	scores	score	NOUN
eurjchem-1346	489	30	in	in	ADP
eurjchem-1346	489	31	the	the	DET
eurjchem-1346	489	32	r	r	NOUN
eurjchem-1346	489	33	eir	eir	PROPN
eurjchem-1346	489	34	ic50	ic50	PROPN
eurjchem-1346	489	35	were	be	AUX
eurjchem-1346	489	36	compounds	compound	NOUN
eurjchem-1346	489	37	6a‐	6a‐	NUM
eurjchem-1346	489	38	.28	.28	NUM
eurjchem-1346	489	39	to	to	ADP
eurjchem-1346	489	40	7.65	7.65	NUM
eurjchem-1346	489	41	nm	nm	NOUN
eurjchem-1346	489	42	)	)	PUNCT
eurjchem-1346	489	43	g	g	PROPN
eurjchem-1346	489	44	scores	score	NOUN
eurjchem-1346	489	45	‐14.65	‐14.65	PROPN
eurjchem-1346	489	46	st	st	PROPN
eurjchem-1346	489	47	docking	docking	PROPN
eurjchem-1346	489	48	sc	sc	PROPN
eurjchem-1346	489	49	rogen	rogen	PROPN
eurjchem-1346	489	50	bonds	bond	NOUN
eurjchem-1346	489	51	(	(	PUNCT
eurjchem-1346	489	52	3	3	X
eurjchem-1346	489	53	.	.	PUNCT
eurjchem-1346	490	1	espectively	espectively	ADV
eurjchem-1346	490	2	,	,	PUNCT
eurjchem-1346	490	3	on	on	ADP
eurjchem-1346	490	4	e	e	NOUN
eurjchem-1346	490	5	arene	arene	NOUN
eurjchem-1346	490	6	cation	cation	NOUN
eurjchem-1346	490	7	in	in	ADP
eurjchem-1346	490	8	mpound	mpound	PROPN
eurjchem-1346	490	9	5d	5d	PROPN
eurjchem-1346	490	10	with	with	ADP
eurjchem-1346	490	11	v	v	ADP
eurjchem-1346	490	12	ompound	ompound	ADJ
eurjchem-1346	490	13	gave	give	VERB
eurjchem-1346	490	14	of	of	ADP
eurjchem-1346	490	15	‐11.3281	‐11.3281	PROPN
eurjchem-1346	490	16	kca	kca	PROPN
eurjchem-1346	490	17	drogen	drogen	PROPN
eurjchem-1346	490	18	bond	bond	PROPN
eurjchem-1346	490	19	wi	wi	PROPN
eurjchem-1346	490	20	ith	ith	PROPN
eurjchem-1346	490	21	phe	phe	PROPN
eurjchem-1346	490	22	583	583	NUM
eurjchem-1346	490	23	.	.	PUNCT
eurjchem-1346	491	1	c	c	PROPN
eurjchem-1346	491	2	exhibited	exhibit	VERB
eurjchem-1346	491	3	good	good	ADJ
eurjchem-1346	491	4	16.0553	16.0553	NUM
eurjchem-1346	491	5	kcal	kcal	NOUN
eurjchem-1346	491	6	/	/	SYM
eurjchem-1346	491	7	m	m	PROPN
eurjchem-1346	491	8	ene	ene	NOUN
eurjchem-1346	491	9	interaction	interaction	NOUN
eurjchem-1346	491	10	with	with	ADP
eurjchem-1346	491	11	phe	phe	PROPN
eurjchem-1346	491	12	583	583	PROPN
eurjchem-1346	491	13	.	.	PUNCT
eurjchem-1346	492	1	pyrazinone	pyrazinone	NOUN
eurjchem-1346	492	2	der	der	ADJ
eurjchem-1346	492	3	mpounds	mpound	NOUN
eurjchem-1346	492	4	have	have	VERB
eurjchem-1346	492	5	s	s	X
eurjchem-1346	492	6	rather	rather	ADV
eurjchem-1346	492	7	than	than	ADP
eurjchem-1346	492	8	re	re	ADP
eurjchem-1346	492	9	t	t	PROPN
eurjchem-1346	492	10	active	active	ADJ
eurjchem-1346	492	11	one	one	NUM
eurjchem-1346	492	12	.	.	PUNCT
eurjchem-1346	493	1	27	27	NUM
eurjchem-1346	493	2	he	he	PRON
eurjchem-1346	493	3	583	583	NUM
eurjchem-1346	493	4	and	and	CCONJ
eurjchem-1346	493	5	trp	trp	PROPN
eurjchem-1346	493	6	83	83	NUM
eurjchem-1346	493	7	(	(	PUNCT
eurjchem-1346	493	8	figure	figure	NOUN
eurjchem-1346	493	9	2	2	NUM
eurjchem-1346	493	10	)	)	PUNCT
eurjchem-1346	493	11	.	.	PUNCT
eurjchem-1346	494	1	ndard	ndard	PROPN
eurjchem-1346	494	2	used	use	VERB
eurjchem-1346	494	3	for	for	ADP
eurjchem-1346	494	4	/mol	/mol	PROPN
eurjchem-1346	494	5	.	.	PUNCT
eurjchem-1346	495	1	sorafenib	sorafenib	PROPN
eurjchem-1346	495	2	d	d	PROPN
eurjchem-1346	495	3	with	with	ADP
eurjchem-1346	495	4	asp	asp	PROPN
eurjchem-1346	495	5	594	594	NUM
eurjchem-1346	495	6	figure	figure	NOUN
eurjchem-1346	495	7	3	3	NUM
eurjchem-1346	495	8	)	)	PUNCT
eurjchem-1346	495	9	.	.	PUNCT
eurjchem-1346	496	1	0ebraf	0ebraf	NOUN
eurjchem-1346	496	2	.	.	PUNCT
eurjchem-1346	497	1	s	s	VERB
eurjchem-1346	497	2	were	be	AUX
eurjchem-1346	497	3	all	all	PRON
eurjchem-1346	497	4	in	in	ADP
eurjchem-1346	497	5	the	the	DET
eurjchem-1346	497	6	pounds	pound	NOUN
eurjchem-1346	497	7	showed	show	VERB
eurjchem-1346	497	8	arene	arene	NOUN
eurjchem-1346	497	9	or	or	CCONJ
eurjchem-1346	497	10	arene	arene	NOUN
eurjchem-1346	497	11	residues	residue	NOUN
eurjchem-1346	497	12	.	.	PUNCT
eurjchem-1346	498	1	only	only	ADV
eurjchem-1346	498	2	nteraction	nteraction	NOUN
eurjchem-1346	498	3	with	with	ADP
eurjchem-1346	498	4	‐15.8120	‐15.8120	PROPN
eurjchem-1346	498	5	and	and	CCONJ
eurjchem-1346	498	6	2	2	NUM
eurjchem-1346	498	7	,	,	PUNCT
eurjchem-1346	498	8	gly	gly	NOUN
eurjchem-1346	498	9	534	534	NUM
eurjchem-1346	498	10	,	,	PUNCT
eurjchem-1346	498	11	phe	phe	NOUN
eurjchem-1346	498	12	acids	acids	ADJ
eurjchem-1346	498	13	residue	residue	NOUN
eurjchem-1346	498	14	‐j	‐j	X
eurjchem-1346	498	15	(	(	PUNCT
eurjchem-1346	498	16	‐10.6210	‐10.6210	NOUN
eurjchem-1346	498	17	to	to	ADP
eurjchem-1346	498	18	)	)	PUNCT
eurjchem-1346	498	19	.	.	PUNCT
eurjchem-1346	499	1	in	in	ADP
eurjchem-1346	499	2	addition	addition	NOUN
eurjchem-1346	499	3	,	,	PUNCT
eurjchem-1346	499	4	range	range	NOUN
eurjchem-1346	499	5	‐13.3412	‐13.3412	PROPN
eurjchem-1346	499	6	0.34‐7.45	0.34‐7.45	PROPN
eurjchem-1346	499	7	nm	nm	PROPN
eurjchem-1346	499	8	.	.	PUNCT
eurjchem-1346	500	1	‐d	‐d	PROPN
eurjchem-1346	501	1	(	(	PUNCT
eurjchem-1346	501	2	‐14.6422	‐14.6422	NOUN
eurjchem-1346	501	3	to	to	PART
eurjchem-1346	501	4	)	)	PUNCT
eurjchem-1346	501	5	.	.	PUNCT
eurjchem-1346	502	1	furthermore	furthermore	ADV
eurjchem-1346	502	2	,	,	PUNCT
eurjchem-1346	502	3	55	55	NUM
eurjchem-1346	502	4	to	to	PART
eurjchem-1346	502	5	‐18.1910	‐18.1910	PROPN
eurjchem-1346	502	6	core	core	NOUN
eurjchem-1346	502	7	(	(	PUNCT
eurjchem-1346	502	8	‐21.0419	‐21.0419	NOUN
eurjchem-1346	502	9	.12	.12	NUM
eurjchem-1346	502	10	and	and	CCONJ
eurjchem-1346	502	11	3.37	3.37	NUM
eurjchem-1346	502	12	å	å	NOUN
eurjchem-1346	502	13	)	)	PUNCT
eurjchem-1346	502	14	e	e	NOUN
eurjchem-1346	502	15	arene	arene	NOUN
eurjchem-1346	502	16	arene	arene	NOUN
eurjchem-1346	502	17	nteraction	nteraction	NOUN
eurjchem-1346	502	18	with	with	ADP
eurjchem-1346	502	19	v600ebraf	v600ebraf	NOUN
eurjchem-1346	502	20	.	.	PUNCT
eurjchem-1346	503	1	best	good	ADJ
eurjchem-1346	503	2	ic50	ic50	PROPN
eurjchem-1346	503	3	(	(	PUNCT
eurjchem-1346	503	4	0.23	0.23	NUM
eurjchem-1346	503	5	al	al	PROPN
eurjchem-1346	503	6	/	/	SYM
eurjchem-1346	503	7	mol	mol	PROPN
eurjchem-1346	503	8	and	and	CCONJ
eurjchem-1346	503	9	bind	bind	VERB
eurjchem-1346	503	10	th	th	PROPN
eurjchem-1346	503	11	cys	cys	PROPN
eurjchem-1346	503	12	532	532	NUM
eurjchem-1346	503	13	and	and	CCONJ
eurjchem-1346	503	14	compound	compound	NOUN
eurjchem-1346	503	15	6b	6b	NOUN
eurjchem-1346	503	16	,	,	PUNCT
eurjchem-1346	503	17	ic50	ic50	PROPN
eurjchem-1346	503	18	(	(	PUNCT
eurjchem-1346	503	19	0.28	0.28	NUM
eurjchem-1346	503	20	nm	nm	NOUN
eurjchem-1346	503	21	)	)	PUNCT
eurjchem-1346	503	22	mol	mol	ADP
eurjchem-1346	503	23	which	which	PRON
eurjchem-1346	503	24	bind	bind	VERB
eurjchem-1346	503	25	n	n	PRON
eurjchem-1346	503	26	with	with	ADP
eurjchem-1346	503	27	lys	lys	PROPN
eurjchem-1346	503	28	483	483	NUM
eurjchem-1346	503	29	rivatives	rivative	NOUN
eurjchem-1346	503	30	were	be	AUX
eurjchem-1346	503	31	e	e	PROPN
eurjchem-1346	503	32	a	a	DET
eurjchem-1346	503	33	significant	significant	ADJ
eurjchem-1346	503	34	est	est	NOUN
eurjchem-1346	503	35	of	of	ADP
eurjchem-1346	503	36	other	other	ADJ
eurjchem-1346	503	37	cell	cell	NOUN
eurjchem-1346	503	38	p	p	NOUN
eurjchem-1346	503	39	r	r	NOUN
eurjchem-1346	503	40	b	b	SYM
eurjchem-1346	503	41	4	4	NUM
eurjchem-1346	503	42	e	e	NOUN
eurjchem-1346	503	43	d	d	X
eurjchem-1346	503	44	e	e	X
eurjchem-1346	503	45	y	y	PROPN
eurjchem-1346	503	46	h	h	NOUN
eurjchem-1346	503	47	d	d	X
eurjchem-1346	503	48	e	e	X
eurjchem-1346	503	49	e	e	X
eurjchem-1346	503	50	o	o	PROPN
eurjchem-1346	503	51	,	,	PUNCT
eurjchem-1346	503	52	2	2	NUM
eurjchem-1346	503	53	.	.	PUNCT
eurjchem-1346	504	1	o	o	INTJ
eurjchem-1346	504	2	,	,	PUNCT
eurjchem-1346	504	3	0	0	NUM
eurjchem-1346	504	4	9	9	NUM
eurjchem-1346	504	5	)	)	PUNCT
eurjchem-1346	504	6	e	e	NOUN
eurjchem-1346	504	7	h	h	NOUN
eurjchem-1346	504	8	3	3	NUM
eurjchem-1346	504	9	d	d	PROPN
eurjchem-1346	504	10	d	d	PROPN
eurjchem-1346	504	11	,	,	PUNCT
eurjchem-1346	504	12	)	)	PUNCT
eurjchem-1346	505	1	d	d	ADP
eurjchem-1346	505	2	3	3	NUM
eurjchem-1346	505	3	e	e	NOUN
eurjchem-1346	505	4	t	t	PROPN
eurjchem-1346	505	5	l	l	PROPN
eurjchem-1346	505	6	28	28	NUM
eurjchem-1346	505	7	amin	amin	PROPN
eurjchem-1346	505	8	et	et	PROPN
eurjchem-1346	505	9	al	al	PROPN
eurjchem-1346	505	10	.	.	PUNCT
eurjchem-1346	505	11	/	/	SYM
eurjchem-1346	505	12	european	european	PROPN
eurjchem-1346	505	13	journal	journal	PROPN
eurjchem-1346	505	14	of	of	ADP
eurjchem-1346	505	15	chemistry	chemistry	NOUN
eurjchem-1346	505	16	7	7	NUM
eurjchem-1346	505	17	(	(	PUNCT
eurjchem-1346	505	18	1	1	NUM
eurjchem-1346	505	19	)	)	PUNCT
eurjchem-1346	505	20	(	(	PUNCT
eurjchem-1346	505	21	2016	2016	NUM
eurjchem-1346	505	22	)	)	PUNCT
eurjchem-1346	505	23	19‐29	19‐29	NUM
eurjchem-1346	505	24	table	table	NOUN
eurjchem-1346	505	25	3	3	NUM
eurjchem-1346	505	26	.	.	PUNCT
eurjchem-1346	506	1	docking	docking	NOUN
eurjchem-1346	506	2	results	result	NOUN
eurjchem-1346	506	3	.	.	PUNCT
eurjchem-1346	507	1	compound	compound	NOUN
eurjchem-1346	507	2	energy	energy	NOUN
eurjchem-1346	507	3	score	score	NOUN
eurjchem-1346	507	4	s	s	PART
eurjchem-1346	507	5	(	(	PUNCT
eurjchem-1346	507	6	kcal	kcal	PROPN
eurjchem-1346	507	7	/	/	SYM
eurjchem-1346	507	8	mol	mol	NOUN
eurjchem-1346	507	9	)	)	PUNCT
eurjchem-1346	507	10	amino	amino	ADJ
eurjchem-1346	507	11	acids	acid	NOUN
eurjchem-1346	507	12	interaction	interaction	NOUN
eurjchem-1346	507	13	interacting	interact	VERB
eurjchem-1346	507	14	groups	group	NOUN
eurjchem-1346	507	15	hydrogen	hydrogen	NOUN
eurjchem-1346	507	16	bond	bond	NOUN
eurjchem-1346	507	17	length	length	NOUN
eurjchem-1346	507	18	(	(	PUNCT
eurjchem-1346	507	19	å	å	NOUN
eurjchem-1346	507	20	)	)	PUNCT
eurjchem-1346	507	21	plx3203	plx3203	VERB
eurjchem-1346	507	22	‐19.2870	‐19.2870	PROPN
eurjchem-1346	507	23	lys	lys	PROPN
eurjchem-1346	507	24	483	483	NUM
eurjchem-1346	507	25	(	(	PUNCT
eurjchem-1346	507	26	arene	arene	NOUN
eurjchem-1346	507	27	cation	cation	NOUN
eurjchem-1346	507	28	)	)	PUNCT
eurjchem-1346	507	29	phenyl	phenyl	NOUN
eurjchem-1346	507	30	ring	ring	NOUN
eurjchem-1346	507	31	trp	trp	PROPN
eurjchem-1346	507	32	531	531	NUM
eurjchem-1346	507	33	(	(	PUNCT
eurjchem-1346	507	34	arene	arene	NOUN
eurjchem-1346	507	35	arene	arene	NOUN
eurjchem-1346	507	36	)	)	PUNCT
eurjchem-1346	507	37	n	n	PRON
eurjchem-1346	507	38	pyridine	pyridine	NOUN
eurjchem-1346	507	39	cys	cys	PROPN
eurjchem-1346	507	40	532	532	NUM
eurjchem-1346	507	41	n	n	PRON
eurjchem-1346	507	42	pyridine	pyridine	NOUN
eurjchem-1346	507	43	3.1	3.1	NUM
eurjchem-1346	507	44	phe	phe	NOUN
eurjchem-1346	507	45	583	583	NUM
eurjchem-1346	507	46	(	(	PUNCT
eurjchem-1346	507	47	arene	arene	NOUN
eurjchem-1346	507	48	arene	arene	NOUN
eurjchem-1346	507	49	)	)	PUNCT
eurjchem-1346	507	50	n	n	PRON
eurjchem-1346	507	51	pyridine	pyridine	NOUN
eurjchem-1346	507	52	phe	phe	NOUN
eurjchem-1346	507	53	583	583	NUM
eurjchem-1346	507	54	(	(	PUNCT
eurjchem-1346	507	55	arene	arene	NOUN
eurjchem-1346	507	56	arene	arene	NOUN
eurjchem-1346	507	57	)	)	PUNCT
eurjchem-1346	507	58	n	n	PRON
eurjchem-1346	507	59	pyrrole	pyrrole	NOUN
eurjchem-1346	507	60	phe	phe	PROPN
eurjchem-1346	507	61	595	595	NUM
eurjchem-1346	507	62	so2	so2	NOUN
eurjchem-1346	507	63	2.99	2.99	NUM
eurjchem-1346	507	64	sorafenib	sorafenib	NOUN
eurjchem-1346	507	65	‐23.4155	‐23.4155	DET
eurjchem-1346	507	66	phe	phe	PROPN
eurjchem-1346	507	67	583	583	NUM
eurjchem-1346	507	68	(	(	PUNCT
eurjchem-1346	507	69	arene	arene	NOUN
eurjchem-1346	507	70	arene	arene	NOUN
eurjchem-1346	507	71	)	)	PUNCT
eurjchem-1346	507	72	phenyl	phenyl	NOUN
eurjchem-1346	507	73	ring	ring	NOUN
eurjchem-1346	507	74	asp	asp	PROPN
eurjchem-1346	508	1	594	594	NUM
eurjchem-1346	508	2	c	c	NOUN
eurjchem-1346	508	3	=	=	NOUN
eurjchem-1346	508	4	o	o	NOUN
eurjchem-1346	508	5	2.6	2.6	NUM
eurjchem-1346	508	6	1	1	NUM
eurjchem-1346	508	7	‐11.3281	‐11.3281	ADP
eurjchem-1346	508	8	cys	cys	PROPN
eurjchem-1346	508	9	532	532	NUM
eurjchem-1346	508	10	n	n	PRON
eurjchem-1346	508	11	pyridine	pyridine	NOUN
eurjchem-1346	508	12	3.02	3.02	NUM
eurjchem-1346	508	13	phe	phe	NOUN
eurjchem-1346	508	14	583	583	NUM
eurjchem-1346	508	15	(	(	PUNCT
eurjchem-1346	508	16	arene	arene	NOUN
eurjchem-1346	508	17	arene	arene	NOUN
eurjchem-1346	508	18	)	)	PUNCT
eurjchem-1346	508	19	pyridine	pyridine	NOUN
eurjchem-1346	508	20	ring	ring	NOUN
eurjchem-1346	508	21	2	2	NUM
eurjchem-1346	508	22	‐13.0101	‐13.0101	PROPN
eurjchem-1346	508	23	cys	cys	PROPN
eurjchem-1346	508	24	532	532	NUM
eurjchem-1346	508	25	n	n	PRON
eurjchem-1346	508	26	pyridine	pyridine	NOUN
eurjchem-1346	508	27	3.05	3.05	NUM
eurjchem-1346	508	28	phe	phe	NOUN
eurjchem-1346	508	29	583	583	NUM
eurjchem-1346	508	30	(	(	PUNCT
eurjchem-1346	508	31	arene	arene	NOUN
eurjchem-1346	508	32	arene	arene	NOUN
eurjchem-1346	508	33	)	)	PUNCT
eurjchem-1346	508	34	pyridine	pyridine	NOUN
eurjchem-1346	508	35	ring	ring	NOUN
eurjchem-1346	508	36	3a	3a	NUM
eurjchem-1346	508	37	‐13.2439	‐13.2439	PROPN
eurjchem-1346	508	38	cys	cys	PROPN
eurjchem-1346	508	39	532	532	NUM
eurjchem-1346	508	40	c	c	NOUN
eurjchem-1346	508	41	=	=	NOUN
eurjchem-1346	508	42	o	o	NOUN
eurjchem-1346	508	43	2.69	2.69	NUM
eurjchem-1346	508	44	phe	phe	NOUN
eurjchem-1346	508	45	583	583	NUM
eurjchem-1346	508	46	(	(	PUNCT
eurjchem-1346	508	47	arene	arene	NOUN
eurjchem-1346	508	48	arene	arene	NOUN
eurjchem-1346	508	49	)	)	PUNCT
eurjchem-1346	508	50	pyridine	pyridine	NOUN
eurjchem-1346	508	51	ring	ring	NOUN
eurjchem-1346	508	52	3b	3b	NOUN
eurjchem-1346	508	53	‐10.6210	‐10.6210	NOUN
eurjchem-1346	508	54	lys	lys	PROPN
eurjchem-1346	508	55	483	483	NUM
eurjchem-1346	508	56	(	(	PUNCT
eurjchem-1346	508	57	arene	arene	NOUN
eurjchem-1346	508	58	cation	cation	NOUN
eurjchem-1346	508	59	)	)	PUNCT
eurjchem-1346	508	60	pyridine	pyridine	NOUN
eurjchem-1346	508	61	ring	ring	NOUN
eurjchem-1346	508	62	phe	phe	PROPN
eurjchem-1346	508	63	583	583	NUM
eurjchem-1346	508	64	(	(	PUNCT
eurjchem-1346	508	65	arene	arene	NOUN
eurjchem-1346	508	66	cation	cation	NOUN
eurjchem-1346	508	67	)	)	PUNCT
eurjchem-1346	508	68	piperidine	piperidine	NOUN
eurjchem-1346	508	69	ring	ring	NOUN
eurjchem-1346	508	70	asp	asp	PROPN
eurjchem-1346	508	71	594	594	NUM
eurjchem-1346	508	72	n	n	PRON
eurjchem-1346	508	73	pyridine	pyridine	NOUN
eurjchem-1346	508	74	2.98	2.98	NUM
eurjchem-1346	508	75	3c	3c	NUM
eurjchem-1346	508	76	‐11.6002	‐11.6002	NOUN
eurjchem-1346	508	77	cys	cys	NOUN
eurjchem-1346	508	78	532	532	NUM
eurjchem-1346	508	79	c	c	NOUN
eurjchem-1346	508	80	=	=	NOUN
eurjchem-1346	508	81	o	o	NOUN
eurjchem-1346	508	82	3.13	3.13	NUM
eurjchem-1346	508	83	phe	phe	NOUN
eurjchem-1346	508	84	583	583	NUM
eurjchem-1346	508	85	(	(	PUNCT
eurjchem-1346	508	86	arene	arene	NOUN
eurjchem-1346	508	87	arene	arene	NOUN
eurjchem-1346	508	88	)	)	PUNCT
eurjchem-1346	508	89	pyridine	pyridine	NOUN
eurjchem-1346	508	90	ring	ring	NOUN
eurjchem-1346	508	91	3d	3d	NUM
eurjchem-1346	508	92	‐17.5978	‐17.5978	NUM
eurjchem-1346	508	93	cys	cys	PROPN
eurjchem-1346	508	94	532	532	NUM
eurjchem-1346	508	95	nh	nh	PROPN
eurjchem-1346	508	96	piperazine	piperazine	NOUN
eurjchem-1346	508	97	2.27	2.27	NUM
eurjchem-1346	508	98	cys	cys	PROPN
eurjchem-1346	508	99	532	532	NUM
eurjchem-1346	508	100	c	c	X
eurjchem-1346	508	101	=	=	NOUN
eurjchem-1346	508	102	o	o	NOUN
eurjchem-1346	508	103	2.69	2.69	NUM
eurjchem-1346	508	104	3e	3e	NOUN
eurjchem-1346	508	105	‐17.7071	‐17.7071	PROPN
eurjchem-1346	508	106	lys	lys	PROPN
eurjchem-1346	508	107	483	483	NUM
eurjchem-1346	508	108	(	(	PUNCT
eurjchem-1346	508	109	arene	arene	NOUN
eurjchem-1346	508	110	cation	cation	NOUN
eurjchem-1346	508	111	)	)	PUNCT
eurjchem-1346	508	112	phenyl	phenyl	NOUN
eurjchem-1346	508	113	ring	ring	NOUN
eurjchem-1346	508	114	3f	3f	PROPN
eurjchem-1346	508	115	‐16.0602	‐16.0602	PROPN
eurjchem-1346	508	116	cys	cys	PROPN
eurjchem-1346	508	117	532	532	NUM
eurjchem-1346	508	118	nh	nh	PROPN
eurjchem-1346	508	119	piperazine	piperazine	NOUN
eurjchem-1346	508	120	1.83	1.83	NUM
eurjchem-1346	508	121	cys	cys	PROPN
eurjchem-1346	508	122	532	532	NUM
eurjchem-1346	508	123	c	c	NOUN
eurjchem-1346	508	124	=	=	NOUN
eurjchem-1346	508	125	o	o	NOUN
eurjchem-1346	508	126	3.22	3.22	NUM
eurjchem-1346	508	127	3	3	NUM
eurjchem-1346	508	128	g	g	NOUN
eurjchem-1346	508	129	‐18.4843	‐18.4843	PROPN
eurjchem-1346	508	130	cys	cys	PROPN
eurjchem-1346	508	131	532	532	NUM
eurjchem-1346	508	132	nh	nh	PROPN
eurjchem-1346	508	133	piperazine	piperazine	NOUN
eurjchem-1346	508	134	2.2	2.2	NUM
eurjchem-1346	508	135	cys	cys	NOUN
eurjchem-1346	508	136	532	532	NUM
eurjchem-1346	508	137	c	c	NOUN
eurjchem-1346	508	138	=	=	NOUN
eurjchem-1346	508	139	o	o	NOUN
eurjchem-1346	508	140	2.61	2.61	NUM
eurjchem-1346	508	141	3h	3h	NUM
eurjchem-1346	508	142	‐18.2255	‐18.2255	PROPN
eurjchem-1346	508	143	cys	cys	PROPN
eurjchem-1346	508	144	532	532	NUM
eurjchem-1346	508	145	nh	nh	PROPN
eurjchem-1346	508	146	piperazine	piperazine	NOUN
eurjchem-1346	508	147	2.26	2.26	NUM
eurjchem-1346	508	148	cys	cys	PROPN
eurjchem-1346	508	149	532	532	NUM
eurjchem-1346	508	150	c	c	NOUN
eurjchem-1346	508	151	=	=	NOUN
eurjchem-1346	508	152	o	o	NOUN
eurjchem-1346	508	153	2.56	2.56	NUM
eurjchem-1346	508	154	3i	3i	NUM
eurjchem-1346	508	155	‐19.0422	‐19.0422	ADP
eurjchem-1346	508	156	cys	cys	PROPN
eurjchem-1346	508	157	532	532	NUM
eurjchem-1346	508	158	nh	nh	PROPN
eurjchem-1346	508	159	piperazine	piperazine	NOUN
eurjchem-1346	508	160	2.24	2.24	NUM
eurjchem-1346	508	161	cys	cys	PROPN
eurjchem-1346	508	162	532	532	NUM
eurjchem-1346	508	163	c	c	X
eurjchem-1346	508	164	=	=	NOUN
eurjchem-1346	508	165	o	o	NOUN
eurjchem-1346	508	166	2.58	2.58	NUM
eurjchem-1346	508	167	3j	3j	NOUN
eurjchem-1346	508	168	‐15.8120	‐15.8120	NOUN
eurjchem-1346	508	169	‐	‐	NOUN
eurjchem-1346	508	170	‐	‐	ADV
eurjchem-1346	508	171	‐	‐	ADV
eurjchem-1346	508	172	4	4	NUM
eurjchem-1346	508	173	‐12.0174	‐12.0174	NOUN
eurjchem-1346	508	174	cys	cys	PROPN
eurjchem-1346	508	175	532	532	NUM
eurjchem-1346	508	176	c	c	NOUN
eurjchem-1346	508	177	=	=	NOUN
eurjchem-1346	508	178	o	o	NOUN
eurjchem-1346	508	179	2.57	2.57	NUM
eurjchem-1346	508	180	gly	gly	NOUN
eurjchem-1346	508	181	534	534	NUM
eurjchem-1346	508	182	nh2	nh2	NOUN
eurjchem-1346	508	183	1.94	1.94	NUM
eurjchem-1346	508	184	phe	phe	NOUN
eurjchem-1346	508	185	583	583	NUM
eurjchem-1346	508	186	(	(	PUNCT
eurjchem-1346	508	187	arene	arene	NOUN
eurjchem-1346	508	188	arene	arene	NOUN
eurjchem-1346	508	189	)	)	PUNCT
eurjchem-1346	508	190	pyridine	pyridine	NOUN
eurjchem-1346	508	191	ring	ring	NOUN
eurjchem-1346	508	192	5a	5a	NUM
eurjchem-1346	508	193	‐16.5954	‐16.5954	PROPN
eurjchem-1346	508	194	lys	lys	PROPN
eurjchem-1346	508	195	483	483	NUM
eurjchem-1346	508	196	(	(	PUNCT
eurjchem-1346	508	197	arene	arene	NOUN
eurjchem-1346	508	198	cation	cation	NOUN
eurjchem-1346	508	199	)	)	PUNCT
eurjchem-1346	508	200	phenyl	phenyl	NOUN
eurjchem-1346	508	201	ring	ring	NOUN
eurjchem-1346	508	202	cys	cys	PROPN
eurjchem-1346	508	203	532	532	NUM
eurjchem-1346	508	204	nh	nh	PROPN
eurjchem-1346	508	205	piperazine	piperazine	NOUN
eurjchem-1346	508	206	1.83	1.83	NUM
eurjchem-1346	508	207	cys	cys	PROPN
eurjchem-1346	508	208	532	532	NUM
eurjchem-1346	508	209	c	c	NOUN
eurjchem-1346	508	210	=	=	NOUN
eurjchem-1346	508	211	o	o	NOUN
eurjchem-1346	508	212	2.52	2.52	NUM
eurjchem-1346	508	213	5b	5b	NUM
eurjchem-1346	508	214	‐16.7560	‐16.7560	ADP
eurjchem-1346	508	215	lys	lys	PROPN
eurjchem-1346	508	216	483	483	NUM
eurjchem-1346	508	217	(	(	PUNCT
eurjchem-1346	508	218	arene	arene	NOUN
eurjchem-1346	508	219	cation	cation	NOUN
eurjchem-1346	508	220	)	)	PUNCT
eurjchem-1346	508	221	pyridine	pyridine	NOUN
eurjchem-1346	508	222	ring	ring	NOUN
eurjchem-1346	508	223	asp	asp	PROPN
eurjchem-1346	508	224	594	594	NUM
eurjchem-1346	508	225	n	n	PRON
eurjchem-1346	508	226	pyridine	pyridine	NOUN
eurjchem-1346	508	227	2.63	2.63	NUM
eurjchem-1346	508	228	5c	5c	NUM
eurjchem-1346	508	229	‐13.3412	‐13.3412	X
eurjchem-1346	508	230	cys	cys	PROPN
eurjchem-1346	508	231	532	532	NUM
eurjchem-1346	508	232	nh	nh	PROPN
eurjchem-1346	508	233	piperazine	piperazine	NOUN
eurjchem-1346	508	234	1.86	1.86	NUM
eurjchem-1346	508	235	cys	cys	PROPN
eurjchem-1346	508	236	532	532	NUM
eurjchem-1346	508	237	c	c	NOUN
eurjchem-1346	508	238	=	=	NOUN
eurjchem-1346	508	239	o	o	NOUN
eurjchem-1346	508	240	2.57	2.57	NUM
eurjchem-1346	508	241	5d	5d	NUM
eurjchem-1346	508	242	‐21.0419	‐21.0419	NOUN
eurjchem-1346	508	243	lys	lys	VERB
eurjchem-1346	508	244	483	483	NUM
eurjchem-1346	508	245	(	(	PUNCT
eurjchem-1346	508	246	arene	arene	NOUN
eurjchem-1346	508	247	cation	cation	NOUN
eurjchem-1346	508	248	)	)	PUNCT
eurjchem-1346	508	249	phenyl	phenyl	NOUN
eurjchem-1346	508	250	ring	ring	NOUN
eurjchem-1346	508	251	lys	lys	PROPN
eurjchem-1346	508	252	483	483	NUM
eurjchem-1346	508	253	och3	och3	ADJ
eurjchem-1346	508	254	3.37	3.37	NUM
eurjchem-1346	508	255	trp	trp	PROPN
eurjchem-1346	508	256	531	531	NUM
eurjchem-1346	508	257	(	(	PUNCT
eurjchem-1346	508	258	arene	arene	NOUN
eurjchem-1346	508	259	arene	arene	NOUN
eurjchem-1346	508	260	)	)	PUNCT
eurjchem-1346	508	261	pyridine	pyridine	NOUN
eurjchem-1346	508	262	ring	ring	NOUN
eurjchem-1346	508	263	asp	asp	PROPN
eurjchem-1346	508	264	594	594	NUM
eurjchem-1346	508	265	och3	och3	ADJ
eurjchem-1346	508	266	3.12	3.12	NUM
eurjchem-1346	508	267	5e	5e	NOUN
eurjchem-1346	508	268	‐18.4503	‐18.4503	NOUN
eurjchem-1346	508	269	lys	lys	PROPN
eurjchem-1346	508	270	483	483	NUM
eurjchem-1346	508	271	(	(	PUNCT
eurjchem-1346	508	272	arene	arene	NOUN
eurjchem-1346	508	273	cation	cation	NOUN
eurjchem-1346	508	274	)	)	PUNCT
eurjchem-1346	508	275	pyridine	pyridine	NOUN
eurjchem-1346	508	276	ring	ring	NOUN
eurjchem-1346	508	277	asp	asp	PROPN
eurjchem-1346	508	278	594	594	NUM
eurjchem-1346	508	279	n	n	PRON
eurjchem-1346	508	280	pyridine	pyridine	NOUN
eurjchem-1346	508	281	2.64	2.64	NUM
eurjchem-1346	508	282	6a	6a	NOUN
eurjchem-1346	508	283	‐14.6422	‐14.6422	PROPN
eurjchem-1346	508	284	cys	cys	PROPN
eurjchem-1346	508	285	532	532	NUM
eurjchem-1346	508	286	c	c	NOUN
eurjchem-1346	508	287	=	=	NOUN
eurjchem-1346	508	288	o	o	NOUN
eurjchem-1346	508	289	2.53	2.53	NUM
eurjchem-1346	508	290	phe	phe	NOUN
eurjchem-1346	508	291	583	583	NUM
eurjchem-1346	508	292	(	(	PUNCT
eurjchem-1346	508	293	arene	arene	NOUN
eurjchem-1346	508	294	arene	arene	NOUN
eurjchem-1346	508	295	)	)	PUNCT
eurjchem-1346	508	296	pyridine	pyridine	NOUN
eurjchem-1346	508	297	ring	ring	NOUN
eurjchem-1346	508	298	6b	6b	PROPN
eurjchem-1346	508	299	‐16.0553	‐16.0553	PROPN
eurjchem-1346	508	300	lys	lys	PROPN
eurjchem-1346	508	301	483	483	NUM
eurjchem-1346	508	302	(	(	PUNCT
eurjchem-1346	508	303	arene	arene	NOUN
eurjchem-1346	508	304	cation	cation	NOUN
eurjchem-1346	508	305	)	)	PUNCT
eurjchem-1346	508	306	phenyl	phenyl	NOUN
eurjchem-1346	508	307	ring	ring	NOUN
eurjchem-1346	508	308	phe	phe	PROPN
eurjchem-1346	508	309	583	583	NUM
eurjchem-1346	508	310	(	(	PUNCT
eurjchem-1346	508	311	arene	arene	NOUN
eurjchem-1346	508	312	arene	arene	NOUN
eurjchem-1346	508	313	)	)	PUNCT
eurjchem-1346	508	314	pyridine	pyridine	NOUN
eurjchem-1346	508	315	ring	ring	NOUN
eurjchem-1346	508	316	6c	6c	PROPN
eurjchem-1346	508	317	‐15.7831	‐15.7831	PROPN
eurjchem-1346	508	318	cys	cys	PROPN
eurjchem-1346	508	319	532	532	NUM
eurjchem-1346	508	320	nh	nh	PROPN
eurjchem-1346	508	321	piperazine	piperazine	NOUN
eurjchem-1346	508	322	1.58	1.58	NUM
eurjchem-1346	508	323	6d	6d	NUM
eurjchem-1346	508	324	‐17.4771	‐17.4771	NOUN
eurjchem-1346	508	325	lys	lys	PROPN
eurjchem-1346	508	326	483	483	NUM
eurjchem-1346	508	327	och3	och3	ADJ
eurjchem-1346	508	328	2.99	2.99	NUM
eurjchem-1346	508	329	7a	7a	NUM
eurjchem-1346	508	330	‐14.6555	‐14.6555	ADP
eurjchem-1346	508	331	‐	‐	NOUN
eurjchem-1346	508	332	‐	‐	ADV
eurjchem-1346	508	333	‐	‐	ADP
eurjchem-1346	508	334	7b	7b	NOUN
eurjchem-1346	509	1	‐17.4101	‐17.4101	PROPN
eurjchem-1346	509	2	lys	lys	VERB
eurjchem-1346	509	3	483	483	NUM
eurjchem-1346	509	4	(	(	PUNCT
eurjchem-1346	509	5	arene	arene	NOUN
eurjchem-1346	509	6	cation	cation	NOUN
eurjchem-1346	509	7	)	)	PUNCT
eurjchem-1346	509	8	pyridine	pyridine	NOUN
eurjchem-1346	509	9	ring	ring	NOUN
eurjchem-1346	509	10	asp	asp	PROPN
eurjchem-1346	509	11	594	594	NUM
eurjchem-1346	509	12	n	n	PROPN
eurjchem-1346	509	13	pyridine	pyridine	NOUN
eurjchem-1346	509	14	2.65	2.65	NUM
eurjchem-1346	509	15	7c	7c	PROPN
eurjchem-1346	509	16	‐	‐	ADP
eurjchem-1346	509	17	18.1910	18.1910	NUM
eurjchem-1346	509	18	lys	lys	PROPN
eurjchem-1346	509	19	483	483	NUM
eurjchem-1346	509	20	(	(	PUNCT
eurjchem-1346	509	21	arene	arene	NOUN
eurjchem-1346	509	22	cation	cation	NOUN
eurjchem-1346	509	23	)	)	PUNCT
eurjchem-1346	509	24	pyridine	pyridine	NOUN
eurjchem-1346	509	25	asp	asp	NOUN
eurjchem-1346	509	26	594	594	NUM
eurjchem-1346	509	27	n	n	PRON
eurjchem-1346	509	28	pyridine	pyridine	NOUN
eurjchem-1346	509	29	2.66	2.66	NUM
eurjchem-1346	509	30	it	it	PRON
eurjchem-1346	509	31	exhibited	exhibit	VERB
eurjchem-1346	509	32	promising	promising	ADJ
eurjchem-1346	509	33	activity	activity	NOUN
eurjchem-1346	509	34	against	against	ADP
eurjchem-1346	509	35	all	all	DET
eurjchem-1346	509	36	tested	test	VERB
eurjchem-1346	509	37	cell	cell	NOUN
eurjchem-1346	509	38	lines	line	NOUN
eurjchem-1346	509	39	.	.	PUNCT
eurjchem-1346	510	1	in	in	ADP
eurjchem-1346	510	2	addition	addition	NOUN
eurjchem-1346	510	3	,	,	PUNCT
eurjchem-1346	510	4	the	the	DET
eurjchem-1346	510	5	in	in	X
eurjchem-1346	510	6	vitro	vitro	X
eurjchem-1346	510	7	kinase	kinase	PROPN
eurjchem-1346	510	8	assay	assay	PROPN
eurjchem-1346	510	9	revealed	reveal	VERB
eurjchem-1346	510	10	that	that	SCONJ
eurjchem-1346	510	11	the	the	DET
eurjchem-1346	510	12	tested	test	VERB
eurjchem-1346	510	13	compounds	compound	NOUN
eurjchem-1346	510	14	were	be	AUX
eurjchem-1346	510	15	more	more	ADV
eurjchem-1346	510	16	active	active	ADJ
eurjchem-1346	510	17	towards	towards	ADP
eurjchem-1346	510	18	v600ebraf	v600ebraf	NOUN
eurjchem-1346	510	19	rather	rather	ADV
eurjchem-1346	510	20	than	than	ADP
eurjchem-1346	510	21	wtbraf	wtbraf	NOUN
eurjchem-1346	510	22	enzyme	enzyme	NOUN
eurjchem-1346	510	23	.	.	PUNCT
eurjchem-1346	511	1	the	the	DET
eurjchem-1346	511	2	docking	docking	NOUN
eurjchem-1346	511	3	study	study	NOUN
eurjchem-1346	511	4	revealed	reveal	VERB
eurjchem-1346	511	5	binding	bind	VERB
eurjchem-1346	511	6	of	of	ADP
eurjchem-1346	511	7	most	most	ADJ
eurjchem-1346	511	8	compounds	compound	NOUN
eurjchem-1346	511	9	with	with	ADP
eurjchem-1346	511	10	cys	cys	PROPN
eurjchem-1346	511	11	532	532	NUM
eurjchem-1346	511	12	at	at	ADP
eurjchem-1346	511	13	the	the	DET
eurjchem-1346	511	14	active	active	ADJ
eurjchem-1346	511	15	site	site	NOUN
eurjchem-1346	511	16	.	.	PUNCT
eurjchem-1346	512	1	finally	finally	ADV
eurjchem-1346	512	2	,	,	PUNCT
eurjchem-1346	512	3	based	base	VERB
eurjchem-1346	512	4	on	on	ADP
eurjchem-1346	512	5	both	both	PRON
eurjchem-1346	512	6	in	in	ADP
eurjchem-1346	512	7	vitro	vitro	X
eurjchem-1346	512	8	and	and	CCONJ
eurjchem-1346	512	9	docking	dock	VERB
eurjchem-1346	512	10	studies	study	NOUN
eurjchem-1346	512	11	,	,	PUNCT
eurjchem-1346	512	12	introduction	introduction	NOUN
eurjchem-1346	512	13	of	of	ADP
eurjchem-1346	512	14	unsubstituted	unsubstituted	ADJ
eurjchem-1346	512	15	,	,	PUNCT
eurjchem-1346	512	16	o‐ch3	o‐ch3	PROPN
eurjchem-1346	512	17	,	,	PUNCT
eurjchem-1346	512	18	p‐cl	p‐cl	NOUN
eurjchem-1346	512	19	,	,	PUNCT
eurjchem-1346	512	20	p‐br	p‐br	NOUN
eurjchem-1346	512	21	phenyl	phenyl	NOUN
eurjchem-1346	512	22	amino	amino	NOUN
eurjchem-1346	512	23	group	group	NOUN
eurjchem-1346	512	24	increased	increase	VERB
eurjchem-1346	512	25	activity	activity	NOUN
eurjchem-1346	512	26	of	of	ADP
eurjchem-1346	512	27	v600ebraf	v600ebraf	NOUN
eurjchem-1346	512	28	inhibitors	inhibitor	NOUN
eurjchem-1346	512	29	(	(	PUNCT
eurjchem-1346	512	30	compounds	compound	NOUN
eurjchem-1346	512	31	3d	3d	NUM
eurjchem-1346	512	32	,	,	PUNCT
eurjchem-1346	512	33	e	e	NOUN
eurjchem-1346	512	34	,	,	PUNCT
eurjchem-1346	512	35	h	h	NOUN
eurjchem-1346	512	36	,	,	PUNCT
eurjchem-1346	512	37	i	i	PROPN
eurjchem-1346	512	38	)	)	PUNCT
eurjchem-1346	512	39	.	.	PUNCT
eurjchem-1346	513	1	also	also	ADV
eurjchem-1346	513	2	shiff	shiff	PROPN
eurjchem-1346	513	3	’s	’s	PART
eurjchem-1346	513	4	compounds	compound	NOUN
eurjchem-1346	513	5	with	with	ADP
eurjchem-1346	513	6	unsubstituted	unsubstituted	ADJ
eurjchem-1346	513	7	benzylidine	benzylidine	NOUN
eurjchem-1346	513	8	increased	increase	VERB
eurjchem-1346	513	9	activity	activity	NOUN
eurjchem-1346	513	10	,	,	PUNCT
eurjchem-1346	513	11	while	while	SCONJ
eurjchem-1346	513	12	p‐substituted	p‐substitute	VERB
eurjchem-1346	513	13	benzylidine	benzylidine	NOUN
eurjchem-1346	513	14	ring	ring	NOUN
eurjchem-1346	513	15	with	with	ADP
eurjchem-1346	513	16	electron	electron	NOUN
eurjchem-1346	513	17	withdrawing	withdraw	VERB
eurjchem-1346	513	18	group	group	NOUN
eurjchem-1346	513	19	decreased	decrease	VERB
eurjchem-1346	513	20	activity	activity	NOUN
eurjchem-1346	513	21	of	of	ADP
eurjchem-1346	513	22	these	these	DET
eurjchem-1346	513	23	inhibitors	inhibitor	NOUN
eurjchem-1346	513	24	(	(	PUNCT
eurjchem-1346	513	25	compounds	compound	VERB
eurjchem-1346	513	26	5d	5d	NUM
eurjchem-1346	513	27	,	,	PUNCT
eurjchem-1346	513	28	e	e	NOUN
eurjchem-1346	513	29	)	)	PUNCT
eurjchem-1346	513	30	.	.	PUNCT
eurjchem-1346	514	1	in	in	ADP
eurjchem-1346	514	2	case	case	NOUN
eurjchem-1346	514	3	of	of	ADP
eurjchem-1346	514	4	tricyclic	tricyclic	ADJ
eurjchem-1346	514	5	derivatives	derivative	NOUN
eurjchem-1346	514	6	;	;	PUNCT
eurjchem-1346	514	7	substitution	substitution	NOUN
eurjchem-1346	514	8	with	with	ADP
eurjchem-1346	514	9	cl	cl	NOUN
eurjchem-1346	514	10	at	at	ADP
eurjchem-1346	514	11	position	position	NOUN
eurjchem-1346	514	12	4	4	NUM
eurjchem-1346	514	13	increased	increase	VERB
eurjchem-1346	514	14	activity	activity	NOUN
eurjchem-1346	514	15	(	(	PUNCT
eurjchem-1346	514	16	compound	compound	NOUN
eurjchem-1346	514	17	6b	6b	NOUN
eurjchem-1346	514	18	)	)	PUNCT
eurjchem-1346	514	19	.	.	PUNCT
eurjchem-1346	515	1	although	although	SCONJ
eurjchem-1346	515	2	the	the	DET
eurjchem-1346	515	3	docking	docking	NOUN
eurjchem-1346	515	4	study	study	NOUN
eurjchem-1346	515	5	showed	show	VERB
eurjchem-1346	515	6	non‐significant	non‐significant	ADJ
eurjchem-1346	515	7	correlation	correlation	NOUN
eurjchem-1346	515	8	with	with	ADP
eurjchem-1346	515	9	results	result	NOUN
eurjchem-1346	515	10	of	of	ADP
eurjchem-1346	515	11	enzyme	enzyme	NOUN
eurjchem-1346	515	12	inhibition	inhibition	NOUN
eurjchem-1346	515	13	assay	assay	VERB
eurjchem-1346	515	14	,	,	PUNCT
eurjchem-1346	515	15	most	most	ADJ
eurjchem-1346	515	16	of	of	ADP
eurjchem-1346	515	17	docked	docked	ADJ
eurjchem-1346	515	18	compounds	compound	NOUN
eurjchem-1346	515	19	shared	share	VERB
eurjchem-1346	515	20	some	some	PRON
eurjchem-1346	515	21	of	of	ADP
eurjchem-1346	515	22	binding	bind	VERB
eurjchem-1346	515	23	interactions	interaction	NOUN
eurjchem-1346	515	24	with	with	ADP
eurjchem-1346	515	25	v600ebraf	v600ebraf	NOUN
eurjchem-1346	515	26	active	active	ADJ
eurjchem-1346	515	27	sites	site	NOUN
eurjchem-1346	515	28	similar	similar	ADJ
eurjchem-1346	515	29	to	to	ADP
eurjchem-1346	515	30	those	those	PRON
eurjchem-1346	515	31	of	of	ADP
eurjchem-1346	515	32	native	native	ADJ
eurjchem-1346	515	33	ligand	ligand	NOUN
eurjchem-1346	515	34	(	(	PUNCT
eurjchem-1346	515	35	plx3203	plx3203	ADJ
eurjchem-1346	515	36	)	)	PUNCT
eurjchem-1346	515	37	.	.	PUNCT
eurjchem-1346	516	1	this	this	PRON
eurjchem-1346	516	2	suggests	suggest	VERB
eurjchem-1346	516	3	that	that	SCONJ
eurjchem-1346	516	4	these	these	DET
eurjchem-1346	516	5	compounds	compound	NOUN
eurjchem-1346	516	6	might	might	AUX
eurjchem-1346	516	7	possibly	possibly	ADV
eurjchem-1346	516	8	act	act	VERB
eurjchem-1346	516	9	as	as	ADP
eurjchem-1346	516	10	v600ebraf	v600ebraf	NOUN
eurjchem-1346	516	11	inhibitors	inhibitor	NOUN
eurjchem-1346	516	12	.	.	PUNCT
eurjchem-1346	517	1	references	reference	NOUN
eurjchem-1346	517	2	[	[	X
eurjchem-1346	517	3	1	1	NUM
eurjchem-1346	517	4	]	]	PUNCT
eurjchem-1346	517	5	.	.	PUNCT
eurjchem-1346	518	1	gupta	gupta	PROPN
eurjchem-1346	518	2	,	,	PUNCT
eurjchem-1346	518	3	s.	s.	PROPN
eurjchem-1346	518	4	chem	chem	PROPN
eurjchem-1346	518	5	.	.	PUNCT
eurjchem-1346	519	1	rev	rev	PROPN
eurjchem-1346	519	2	.	.	PROPN
eurjchem-1346	519	3	1994	1994	NUM
eurjchem-1346	519	4	,	,	PUNCT
eurjchem-1346	519	5	94	94	NUM
eurjchem-1346	519	6	(	(	PUNCT
eurjchem-1346	519	7	6	6	NUM
eurjchem-1346	519	8	)	)	PUNCT
eurjchem-1346	519	9	,	,	PUNCT
eurjchem-1346	519	10	1507‐1551	1507‐1551	X
eurjchem-1346	519	11	.	.	PUNCT
eurjchem-1346	520	1	[	[	X
eurjchem-1346	520	2	2	2	NUM
eurjchem-1346	520	3	]	]	PUNCT
eurjchem-1346	520	4	.	.	PUNCT
eurjchem-1346	521	1	sparano	sparano	PROPN
eurjchem-1346	521	2	,	,	PUNCT
eurjchem-1346	521	3	j.	j.	PROPN
eurjchem-1346	521	4	a.	a.	PROPN
eurjchem-1346	521	5	,	,	PUNCT
eurjchem-1346	521	6	in	in	ADP
eurjchem-1346	521	7	molecular	molecular	ADJ
eurjchem-1346	521	8	targeting	target	VERB
eurjchem-1346	521	9	in	in	ADP
eurjchem-1346	521	10	oncology	oncology	NOUN
eurjchem-1346	521	11	,	,	PUNCT
eurjchem-1346	521	12	springer	springer	NOUN
eurjchem-1346	521	13	:	:	PUNCT
eurjchem-1346	521	14	2008	2008	NUM
eurjchem-1346	521	15	,	,	PUNCT
eurjchem-1346	521	16	pp	pp	ADP
eurjchem-1346	521	17	55‐73	55‐73	NUM
eurjchem-1346	521	18	.	.	PUNCT
eurjchem-1346	522	1	[	[	X
eurjchem-1346	522	2	3	3	NUM
eurjchem-1346	522	3	]	]	PUNCT
eurjchem-1346	522	4	.	.	PUNCT
eurjchem-1346	523	1	sebolt‐leopold	sebolt‐leopold	PROPN
eurjchem-1346	523	2	,	,	PUNCT
eurjchem-1346	523	3	j.	j.	PROPN
eurjchem-1346	523	4	s.	s.	PROPN
eurjchem-1346	523	5	;	;	PUNCT
eurjchem-1346	523	6	herrera	herrera	PROPN
eurjchem-1346	523	7	,	,	PUNCT
eurjchem-1346	523	8	r.	r.	PROPN
eurjchem-1346	523	9	nat	nat	PROPN
eurjchem-1346	523	10	.	.	PUNCT
eurjchem-1346	524	1	rev	rev	PROPN
eurjchem-1346	524	2	.	.	PROPN
eurjchem-1346	525	1	cancer	cancer	PROPN
eurjchem-1346	525	2	2004	2004	NUM
eurjchem-1346	525	3	,	,	PUNCT
eurjchem-1346	525	4	4(12	4(12	NUM
eurjchem-1346	525	5	)	)	PUNCT
eurjchem-1346	525	6	,	,	PUNCT
eurjchem-1346	525	7	937‐	937‐	PROPN
eurjchem-1346	525	8	947	947	NUM
eurjchem-1346	525	9	.	.	PUNCT
eurjchem-1346	526	1	[	[	X
eurjchem-1346	526	2	4	4	NUM
eurjchem-1346	526	3	]	]	PUNCT
eurjchem-1346	526	4	.	.	PUNCT
eurjchem-1346	527	1	zebisch	zebisch	PROPN
eurjchem-1346	527	2	,	,	PUNCT
eurjchem-1346	527	3	a.	a.	NOUN
eurjchem-1346	527	4	;	;	PUNCT
eurjchem-1346	527	5	troppmair	troppmair	PROPN
eurjchem-1346	527	6	,	,	PUNCT
eurjchem-1346	527	7	j.	j.	PROPN
eurjchem-1346	527	8	cell	cell	PROPN
eurjchem-1346	527	9	.	.	PUNCT
eurjchem-1346	528	1	mol	mol	PROPN
eurjchem-1346	528	2	.	.	PROPN
eurjchem-1346	528	3	life	life	PROPN
eurjchem-1346	528	4	sci	sci	PROPN
eurjchem-1346	528	5	.	.	PROPN
eurjchem-1346	528	6	cmls	cmls	PROPN
eurjchem-1346	528	7	2006	2006	NUM
eurjchem-1346	528	8	,	,	PUNCT
eurjchem-1346	528	9	63(11	63(11	NOUN
eurjchem-1346	528	10	)	)	PUNCT
eurjchem-1346	528	11	,	,	PUNCT
eurjchem-1346	528	12	1314‐	1314‐	NUM
eurjchem-1346	528	13	1330	1330	NUM
eurjchem-1346	528	14	.	.	PUNCT
eurjchem-1346	529	1	[	[	X
eurjchem-1346	529	2	5	5	NUM
eurjchem-1346	529	3	]	]	PUNCT
eurjchem-1346	529	4	.	.	PUNCT
eurjchem-1346	530	1	wan	wan	PROPN
eurjchem-1346	530	2	,	,	PUNCT
eurjchem-1346	530	3	p.	p.	PROPN
eurjchem-1346	530	4	t.	t.	PROPN
eurjchem-1346	530	5	;	;	PUNCT
eurjchem-1346	530	6	garnett	garnett	PROPN
eurjchem-1346	530	7	,	,	PUNCT
eurjchem-1346	530	8	m.	m.	NOUN
eurjchem-1346	530	9	j.	j.	PROPN
eurjchem-1346	530	10	;	;	PUNCT
eurjchem-1346	530	11	roe	roe	PROPN
eurjchem-1346	530	12	,	,	PUNCT
eurjchem-1346	530	13	s.	s.	PROPN
eurjchem-1346	530	14	m.	m.	PROPN
eurjchem-1346	530	15	;	;	PUNCT
eurjchem-1346	530	16	lee	lee	PROPN
eurjchem-1346	530	17	,	,	PUNCT
eurjchem-1346	530	18	s.	s.	PROPN
eurjchem-1346	530	19	;	;	PUNCT
eurjchem-1346	530	20	niculescu‐duvaz	niculescu‐duvaz	PROPN
eurjchem-1346	530	21	,	,	PUNCT
eurjchem-1346	530	22	d.	d.	PROPN
eurjchem-1346	530	23	;	;	PUNCT
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eurjchem-1346	530	25	,	,	PUNCT
eurjchem-1346	530	26	v.	v.	ADP
eurjchem-1346	530	27	m.	m.	NOUN
eurjchem-1346	530	28	;	;	PUNCT
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eurjchem-1346	530	30	,	,	PUNCT
eurjchem-1346	530	31	c.	c.	PROPN
eurjchem-1346	530	32	g.	g.	PROPN
eurjchem-1346	530	33	;	;	PUNCT
eurjchem-1346	530	34	jones	jones	PROPN
eurjchem-1346	530	35	,	,	PUNCT
eurjchem-1346	530	36	c.	c.	PROPN
eurjchem-1346	530	37	m.	m.	NOUN
eurjchem-1346	530	38	;	;	PUNCT
eurjchem-1346	530	39	marshall	marshall	PROPN
eurjchem-1346	530	40	,	,	PUNCT
eurjchem-1346	530	41	c.	c.	PROPN
eurjchem-1346	530	42	j.	j.	PROPN
eurjchem-1346	530	43	;	;	PUNCT
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eurjchem-1346	530	45	,	,	PUNCT
eurjchem-1346	530	46	c.	c.	PROPN
eurjchem-1346	530	47	j.	j.	PROPN
eurjchem-1346	530	48	cell	cell	PROPN
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eurjchem-1346	530	50	,	,	PUNCT
eurjchem-1346	530	51	116(6	116(6	NUM
eurjchem-1346	530	52	)	)	PUNCT
eurjchem-1346	530	53	,	,	PUNCT
eurjchem-1346	530	54	855‐867	855‐867	NUM
eurjchem-1346	530	55	.	.	PUNCT
eurjchem-1346	531	1	[	[	X
eurjchem-1346	531	2	6	6	NUM
eurjchem-1346	531	3	]	]	PUNCT
eurjchem-1346	531	4	.	.	PUNCT
eurjchem-1346	532	1	davies	davy	NOUN
eurjchem-1346	532	2	,	,	PUNCT
eurjchem-1346	532	3	h.	h.	PROPN
eurjchem-1346	532	4	;	;	PUNCT
eurjchem-1346	532	5	bignell	bignell	PROPN
eurjchem-1346	532	6	,	,	PUNCT
eurjchem-1346	532	7	g.	g.	PROPN
eurjchem-1346	532	8	r.	r.	PROPN
eurjchem-1346	532	9	;	;	PUNCT
eurjchem-1346	532	10	cox	cox	PROPN
eurjchem-1346	532	11	,	,	PUNCT
eurjchem-1346	532	12	c.	c.	PROPN
eurjchem-1346	532	13	;	;	PUNCT
eurjchem-1346	532	14	stephens	stephen	NOUN
eurjchem-1346	532	15	,	,	PUNCT
eurjchem-1346	532	16	p.	p.	NOUN
eurjchem-1346	532	17	;	;	PUNCT
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eurjchem-1346	532	19	,	,	PUNCT
eurjchem-1346	532	20	s.	s.	PROPN
eurjchem-1346	532	21	;	;	PUNCT
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eurjchem-1346	532	23	,	,	PUNCT
eurjchem-1346	532	24	s.	s.	PROPN
eurjchem-1346	532	25	;	;	PUNCT
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eurjchem-1346	532	27	,	,	PUNCT
eurjchem-1346	532	28	j.	j.	PROPN
eurjchem-1346	532	29	;	;	PUNCT
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eurjchem-1346	532	31	,	,	PUNCT
eurjchem-1346	532	32	h.	h.	PROPN
eurjchem-1346	532	33	;	;	PUNCT
eurjchem-1346	532	34	garnett	garnett	PROPN
eurjchem-1346	532	35	,	,	PUNCT
eurjchem-1346	532	36	m.	m.	NOUN
eurjchem-1346	532	37	j.	j.	PROPN
eurjchem-1346	532	38	;	;	PUNCT
eurjchem-1346	532	39	bottomley	bottomley	PROPN
eurjchem-1346	532	40	,	,	PUNCT
eurjchem-1346	532	41	w.	w.	PROPN
eurjchem-1346	532	42	nature	nature	PROPN
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eurjchem-1346	532	44	,	,	PUNCT
eurjchem-1346	532	45	417(6892	417(6892	PROPN
eurjchem-1346	532	46	)	)	PUNCT
eurjchem-1346	532	47	,	,	PUNCT
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eurjchem-1346	532	49	.	.	PUNCT
eurjchem-1346	533	1	[	[	X
eurjchem-1346	533	2	7	7	NUM
eurjchem-1346	533	3	]	]	PUNCT
eurjchem-1346	533	4	.	.	PUNCT
eurjchem-1346	534	1	garnett	garnett	PROPN
eurjchem-1346	534	2	,	,	PUNCT
eurjchem-1346	534	3	m.	m.	PROPN
eurjchem-1346	534	4	j.	j.	PROPN
eurjchem-1346	534	5	;	;	PUNCT
eurjchem-1346	534	6	marais	marais	PROPN
eurjchem-1346	534	7	,	,	PUNCT
eurjchem-1346	534	8	r.	r.	PROPN
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eurjchem-1346	534	12	,	,	PUNCT
eurjchem-1346	534	13	6(4	6(4	NUM
eurjchem-1346	534	14	)	)	PUNCT
eurjchem-1346	534	15	,	,	PUNCT
eurjchem-1346	534	16	313‐319	313‐319	PROPN
eurjchem-1346	534	17	.	.	PUNCT
eurjchem-1346	535	1	amin	amin	PROPN
eurjchem-1346	535	2	et	et	PROPN
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eurjchem-1346	535	4	.	.	PUNCT
eurjchem-1346	535	5	/	/	SYM
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eurjchem-1346	535	7	journal	journal	PROPN
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eurjchem-1346	535	11	(	(	PUNCT
eurjchem-1346	535	12	1	1	NUM
eurjchem-1346	535	13	)	)	PUNCT
eurjchem-1346	535	14	(	(	PUNCT
eurjchem-1346	535	15	2016	2016	NUM
eurjchem-1346	535	16	)	)	PUNCT
eurjchem-1346	535	17	19‐29	19‐29	NOUN
eurjchem-1346	535	18	29	29	NUM
eurjchem-1346	536	1	[	[	X
eurjchem-1346	536	2	8	8	NUM
eurjchem-1346	536	3	]	]	PUNCT
eurjchem-1346	536	4	.	.	PUNCT
eurjchem-1346	537	1	dibb	dibb	PROPN
eurjchem-1346	537	2	,	,	PUNCT
eurjchem-1346	537	3	n.	n.	PROPN
eurjchem-1346	537	4	j.	j.	PROPN
eurjchem-1346	537	5	;	;	PUNCT
eurjchem-1346	537	6	dilworth	dilworth	PROPN
eurjchem-1346	537	7	,	,	PUNCT
eurjchem-1346	537	8	s.	s.	PROPN
eurjchem-1346	537	9	m.	m.	PROPN
eurjchem-1346	537	10	;	;	PUNCT
eurjchem-1346	537	11	mol	mol	PROPN
eurjchem-1346	537	12	,	,	PUNCT
eurjchem-1346	537	13	c.	c.	PROPN
eurjchem-1346	537	14	d.	d.	PROPN
eurjchem-1346	537	15	nat	nat	PROPN
eurjchem-1346	537	16	.	.	PUNCT
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eurjchem-1346	538	2	.	.	PROPN
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eurjchem-1346	539	2	2004	2004	NUM
eurjchem-1346	539	3	,	,	PUNCT
eurjchem-1346	539	4	4(9	4(9	NUM
eurjchem-1346	539	5	)	)	PUNCT
eurjchem-1346	539	6	,	,	PUNCT
eurjchem-1346	539	7	718‐	718‐	NUM
eurjchem-1346	539	8	727	727	NUM
eurjchem-1346	539	9	.	.	PUNCT
eurjchem-1346	540	1	[	[	X
eurjchem-1346	540	2	9	9	NUM
eurjchem-1346	540	3	]	]	PUNCT
eurjchem-1346	540	4	.	.	PUNCT
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eurjchem-1346	541	2	,	,	PUNCT
eurjchem-1346	541	3	y.	y.	PROPN
eurjchem-1346	541	4	;	;	PUNCT
eurjchem-1346	541	5	xing	xing	PROPN
eurjchem-1346	541	6	,	,	PUNCT
eurjchem-1346	541	7	m.	m.	NOUN
eurjchem-1346	541	8	;	;	PUNCT
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eurjchem-1346	541	10	,	,	PUNCT
eurjchem-1346	541	11	e.	e.	PROPN
eurjchem-1346	541	12	;	;	PUNCT
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eurjchem-1346	541	14	,	,	PUNCT
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eurjchem-1346	541	16	;	;	PUNCT
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eurjchem-1346	541	18	,	,	PUNCT
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eurjchem-1346	541	20	;	;	PUNCT
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eurjchem-1346	541	22	,	,	PUNCT
eurjchem-1346	541	23	b.	b.	PROPN
eurjchem-1346	541	24	;	;	PUNCT
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eurjchem-1346	541	26	,	,	PUNCT
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eurjchem-1346	541	28	;	;	PUNCT
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eurjchem-1346	541	30	,	,	PUNCT
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eurjchem-1346	541	32	h.	h.	PROPN
eurjchem-1346	541	33	;	;	PUNCT
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eurjchem-1346	541	35	,	,	PUNCT
eurjchem-1346	541	36	p.	p.	PROPN
eurjchem-1346	541	37	w.	w.	PROPN
eurjchem-1346	541	38	;	;	PUNCT
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eurjchem-1346	541	40	,	,	PUNCT
eurjchem-1346	541	41	d.	d.	PROPN
eurjchem-1346	541	42	j.	j.	PROPN
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eurjchem-1346	541	44	inst	inst	PROPN
eurjchem-1346	541	45	.	.	PUNCT
eurjchem-1346	541	46	natl	natl	PROPN
eurjchem-1346	541	47	.	.	PUNCT
eurjchem-1346	541	48	2003	2003	NUM
eurjchem-1346	541	49	,	,	PUNCT
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eurjchem-1346	541	51	)	)	PUNCT
eurjchem-1346	541	52	,	,	PUNCT
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eurjchem-1346	541	54	.	.	PUNCT
eurjchem-1346	542	1	[	[	X
eurjchem-1346	542	2	10	10	NUM
eurjchem-1346	542	3	]	]	PUNCT
eurjchem-1346	542	4	.	.	PUNCT
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eurjchem-1346	543	2	,	,	PUNCT
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eurjchem-1346	543	4	;	;	PUNCT
eurjchem-1346	543	5	quiros	quiros	PROPN
eurjchem-1346	543	6	,	,	PUNCT
eurjchem-1346	543	7	r.	r.	PROPN
eurjchem-1346	543	8	m.	m.	PROPN
eurjchem-1346	543	9	;	;	PUNCT
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eurjchem-1346	543	11	,	,	PUNCT
eurjchem-1346	543	12	p.	p.	PROPN
eurjchem-1346	543	13	;	;	PUNCT
eurjchem-1346	543	14	ain	ain	PROPN
eurjchem-1346	543	15	,	,	PUNCT
eurjchem-1346	543	16	k.	k.	PROPN
eurjchem-1346	543	17	b.	b.	PROPN
eurjchem-1346	543	18	;	;	PUNCT
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eurjchem-1346	543	20	,	,	PUNCT
eurjchem-1346	543	21	r.	r.	PROPN
eurjchem-1346	543	22	a.	a.	PROPN
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eurjchem-1346	543	24	res	re	NOUN
eurjchem-1346	543	25	.	.	PUNCT
eurjchem-1346	543	26	2003	2003	NUM
eurjchem-1346	543	27	,	,	PUNCT
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eurjchem-1346	543	29	)	)	PUNCT
eurjchem-1346	543	30	,	,	PUNCT
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eurjchem-1346	543	32	.	.	PUNCT
eurjchem-1346	544	1	[	[	X
eurjchem-1346	544	2	11	11	NUM
eurjchem-1346	544	3	]	]	PUNCT
eurjchem-1346	544	4	.	.	PUNCT
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eurjchem-1346	545	2	,	,	PUNCT
eurjchem-1346	545	3	j.	j.	PROPN
eurjchem-1346	545	4	h.	h.	PROPN
eurjchem-1346	545	5	;	;	PUNCT
eurjchem-1346	545	6	lee	lee	PROPN
eurjchem-1346	545	7	,	,	PUNCT
eurjchem-1346	545	8	e.	e.	PROPN
eurjchem-1346	545	9	s.	s.	PROPN
eurjchem-1346	545	10	;	;	PUNCT
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eurjchem-1346	545	12	,	,	PUNCT
eurjchem-1346	545	13	y.	y.	PROPN
eurjchem-1346	545	14	s.	s.	PROPN
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eurjchem-1346	545	17	,	,	PUNCT
eurjchem-1346	545	18	110(1	110(1	NUM
eurjchem-1346	545	19	)	)	PUNCT
eurjchem-1346	545	20	,	,	PUNCT
eurjchem-1346	545	21	38‐46	38‐46	NUM
eurjchem-1346	545	22	.	.	PUNCT
eurjchem-1346	546	1	[	[	X
eurjchem-1346	546	2	12	12	NUM
eurjchem-1346	546	3	]	]	PUNCT
eurjchem-1346	546	4	.	.	PUNCT
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eurjchem-1346	547	2	,	,	PUNCT
eurjchem-1346	547	3	d.	d.	PROPN
eurjchem-1346	547	4	s.	s.	PROPN
eurjchem-1346	547	5	;	;	PUNCT
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eurjchem-1346	547	7	,	,	PUNCT
eurjchem-1346	547	8	l.	l.	PROPN
eurjchem-1346	547	9	;	;	PUNCT
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eurjchem-1346	547	11	,	,	PUNCT
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eurjchem-1346	547	13	;	;	PUNCT
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eurjchem-1346	547	16	l.	l.	PROPN
eurjchem-1346	547	17	g.	g.	PROPN
eurjchem-1346	547	18	;	;	PUNCT
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eurjchem-1346	547	20	,	,	PUNCT
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eurjchem-1346	547	22	;	;	PUNCT
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eurjchem-1346	547	24	,	,	PUNCT
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eurjchem-1346	547	26	;	;	PUNCT
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eurjchem-1346	547	28	,	,	PUNCT
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eurjchem-1346	547	33	,	,	PUNCT
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eurjchem-1346	547	37	,	,	PUNCT
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eurjchem-1346	547	41	,	,	PUNCT
eurjchem-1346	547	42	r.	r.	PROPN
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eurjchem-1346	547	44	.	.	PUNCT
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eurjchem-1346	548	5	,	,	PUNCT
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eurjchem-1346	548	7	)	)	PUNCT
eurjchem-1346	548	8	,	,	PUNCT
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eurjchem-1346	548	10	.	.	PUNCT
eurjchem-1346	549	1	[	[	X
eurjchem-1346	549	2	13	13	NUM
eurjchem-1346	549	3	]	]	PUNCT
eurjchem-1346	549	4	.	.	PUNCT
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eurjchem-1346	550	2	,	,	PUNCT
eurjchem-1346	550	3	v.	v.	PROPN
eurjchem-1346	550	4	;	;	PUNCT
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eurjchem-1346	550	6	,	,	PUNCT
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eurjchem-1346	550	8	;	;	PUNCT
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eurjchem-1346	550	10	,	,	PUNCT
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eurjchem-1346	550	12	nature	nature	PROPN
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eurjchem-1346	550	16	)	)	PUNCT
eurjchem-1346	550	17	,	,	PUNCT
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eurjchem-1346	551	2	14	14	NUM
eurjchem-1346	551	3	]	]	SYM
eurjchem-1346	551	4	.	.	PUNCT
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eurjchem-1346	552	2	,	,	PUNCT
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eurjchem-1346	552	4	;	;	PUNCT
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eurjchem-1346	552	6	,	,	PUNCT
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eurjchem-1346	552	8	;	;	PUNCT
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eurjchem-1346	552	18	,	,	PUNCT
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eurjchem-1346	552	28	;	;	PUNCT
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eurjchem-1346	552	30	,	,	PUNCT
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eurjchem-1346	552	32	;	;	PUNCT
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eurjchem-1346	552	34	,	,	PUNCT
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eurjchem-1346	552	36	;	;	PUNCT
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eurjchem-1346	552	38	,	,	PUNCT
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eurjchem-1346	552	46	)	)	PUNCT
eurjchem-1346	552	47	,	,	PUNCT
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eurjchem-1346	553	2	15	15	NUM
eurjchem-1346	553	3	]	]	PUNCT
eurjchem-1346	553	4	.	.	PUNCT
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eurjchem-1346	554	5	;	;	PUNCT
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eurjchem-1346	554	20	;	;	PUNCT
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eurjchem-1346	554	22	,	,	PUNCT
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eurjchem-1346	554	43	,	,	PUNCT
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eurjchem-1346	554	50	,	,	PUNCT
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eurjchem-1346	554	52	)	)	PUNCT
eurjchem-1346	554	53	,	,	PUNCT
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eurjchem-1346	554	55	.	.	PUNCT
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eurjchem-1346	555	2	16	16	NUM
eurjchem-1346	555	3	]	]	PUNCT
eurjchem-1346	555	4	.	.	PUNCT
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eurjchem-1346	556	2	,	,	PUNCT
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eurjchem-1346	556	4	;	;	PUNCT
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eurjchem-1346	556	14	,	,	PUNCT
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eurjchem-1346	556	18	,	,	PUNCT
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eurjchem-1346	556	22	,	,	PUNCT
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eurjchem-1346	556	26	,	,	PUNCT
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eurjchem-1346	556	43	,	,	PUNCT
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eurjchem-1346	556	45	)	)	PUNCT
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eurjchem-1346	557	3	]	]	SYM
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eurjchem-1346	557	10	,	,	PUNCT
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eurjchem-1346	557	12	;	;	PUNCT
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eurjchem-1346	557	14	,	,	PUNCT
eurjchem-1346	557	15	k.	k.	PROPN
eurjchem-1346	557	16	;	;	PUNCT
eurjchem-1346	557	17	gore	gore	PROPN
eurjchem-1346	557	18	,	,	PUNCT
eurjchem-1346	557	19	m.	m.	NOUN
eurjchem-1346	557	20	;	;	PUNCT
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eurjchem-1346	557	22	,	,	PUNCT
eurjchem-1346	557	23	s.	s.	PROPN
eurjchem-1346	557	24	;	;	PUNCT
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eurjchem-1346	557	26	,	,	PUNCT
eurjchem-1346	557	27	r.	r.	PROPN
eurjchem-1346	557	28	;	;	PUNCT
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eurjchem-1346	557	30	,	,	PUNCT
eurjchem-1346	557	31	i.	i.	PROPN
eurjchem-1346	557	32	;	;	PUNCT
eurjchem-1346	557	33	hackett	hackett	PROPN
eurjchem-1346	557	34	,	,	PUNCT
eurjchem-1346	557	35	s.	s.	PROPN
eurjchem-1346	557	36	;	;	PUNCT
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eurjchem-1346	557	38	,	,	PUNCT
eurjchem-1346	557	39	m.	m.	NOUN
eurjchem-1346	557	40	;	;	PUNCT
eurjchem-1346	557	41	schuchter	schuchter	PROPN
eurjchem-1346	557	42	,	,	PUNCT
eurjchem-1346	558	1	l.	l.	PROPN
eurjchem-1346	558	2	br	br	PROPN
eurjchem-1346	558	3	.	.	PUNCT
eurjchem-1346	559	1	j.	j.	PROPN
eurjchem-1346	559	2	cancer	cancer	PROPN
eurjchem-1346	559	3	2006	2006	NUM
eurjchem-1346	559	4	,	,	PUNCT
eurjchem-1346	559	5	95(5	95(5	NUM
eurjchem-1346	559	6	)	)	PUNCT
eurjchem-1346	559	7	,	,	PUNCT
eurjchem-1346	559	8	581‐586	581‐586	NUM
eurjchem-1346	559	9	.	.	PUNCT
eurjchem-1346	560	1	[	[	X
eurjchem-1346	560	2	18	18	NUM
eurjchem-1346	560	3	]	]	PUNCT
eurjchem-1346	560	4	.	.	PUNCT
eurjchem-1346	561	1	wilhelm	wilhelm	PROPN
eurjchem-1346	561	2	,	,	PUNCT
eurjchem-1346	561	3	s.	s.	PROPN
eurjchem-1346	561	4	m.	m.	PROPN
eurjchem-1346	561	5	;	;	PUNCT
eurjchem-1346	561	6	carter	carter	PROPN
eurjchem-1346	561	7	,	,	PUNCT
eurjchem-1346	561	8	c.	c.	PROPN
eurjchem-1346	561	9	;	;	PUNCT
eurjchem-1346	561	10	tang	tang	PROPN
eurjchem-1346	561	11	,	,	PUNCT
eurjchem-1346	561	12	l.	l.	PROPN
eurjchem-1346	561	13	;	;	PUNCT
eurjchem-1346	561	14	wilkie	wilkie	PROPN
eurjchem-1346	561	15	,	,	PUNCT
eurjchem-1346	561	16	d.	d.	PROPN
eurjchem-1346	561	17	;	;	PUNCT
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eurjchem-1346	561	19	,	,	PUNCT
eurjchem-1346	561	20	a.	a.	PROPN
eurjchem-1346	561	21	;	;	PUNCT
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eurjchem-1346	561	23	,	,	PUNCT
eurjchem-1346	561	24	h.	h.	PROPN
eurjchem-1346	561	25	;	;	PUNCT
eurjchem-1346	561	26	chen	chen	PROPN
eurjchem-1346	561	27	,	,	PUNCT
eurjchem-1346	561	28	c.	c.	PROPN
eurjchem-1346	561	29	;	;	PUNCT
eurjchem-1346	561	30	zhang	zhang	PROPN
eurjchem-1346	561	31	,	,	PUNCT
eurjchem-1346	561	32	x.	x.	PROPN
eurjchem-1346	561	33	;	;	PUNCT
eurjchem-1346	561	34	vincent	vincent	PROPN
eurjchem-1346	561	35	,	,	PUNCT
eurjchem-1346	561	36	p.	p.	PROPN
eurjchem-1346	561	37	;	;	PUNCT
eurjchem-1346	561	38	mchugh	mchugh	PROPN
eurjchem-1346	561	39	,	,	PUNCT
eurjchem-1346	561	40	m.	m.	NOUN
eurjchem-1346	561	41	cancer	cancer	NOUN
eurjchem-1346	561	42	res	re	NOUN
eurjchem-1346	561	43	.	.	PUNCT
eurjchem-1346	561	44	2004	2004	NUM
eurjchem-1346	561	45	,	,	PUNCT
eurjchem-1346	561	46	64(19	64(19	NUM
eurjchem-1346	561	47	)	)	PUNCT
eurjchem-1346	561	48	,	,	PUNCT
eurjchem-1346	562	1	7099‐7109	7099‐7109	NUM
eurjchem-1346	562	2	.	.	PUNCT
eurjchem-1346	563	1	[	[	X
eurjchem-1346	563	2	19	19	NUM
eurjchem-1346	563	3	]	]	PUNCT
eurjchem-1346	563	4	.	.	PUNCT
eurjchem-1346	564	1	ratain	ratain	PROPN
eurjchem-1346	564	2	,	,	PUNCT
eurjchem-1346	564	3	m.	m.	NOUN
eurjchem-1346	564	4	j.	j.	PROPN
eurjchem-1346	564	5	;	;	PUNCT
eurjchem-1346	564	6	eisen	eisen	NOUN
eurjchem-1346	564	7	,	,	PUNCT
eurjchem-1346	564	8	t.	t.	PROPN
eurjchem-1346	564	9	;	;	PUNCT
eurjchem-1346	564	10	stadler	stadler	NOUN
eurjchem-1346	564	11	,	,	PUNCT
eurjchem-1346	564	12	w.	w.	PROPN
eurjchem-1346	564	13	m.	m.	PROPN
eurjchem-1346	564	14	;	;	PUNCT
eurjchem-1346	564	15	flaherty	flaherty	PROPN
eurjchem-1346	564	16	,	,	PUNCT
eurjchem-1346	564	17	k.	k.	PROPN
eurjchem-1346	564	18	t.	t.	PROPN
eurjchem-1346	564	19	;	;	PUNCT
eurjchem-1346	564	20	kaye	kaye	PROPN
eurjchem-1346	564	21	,	,	PUNCT
eurjchem-1346	564	22	s.	s.	PROPN
eurjchem-1346	564	23	b.	b.	PROPN
eurjchem-1346	564	24	;	;	PUNCT
eurjchem-1346	564	25	rosner	rosner	PROPN
eurjchem-1346	564	26	,	,	PUNCT
eurjchem-1346	564	27	g.	g.	PROPN
eurjchem-1346	564	28	l.	l.	PROPN
eurjchem-1346	564	29	;	;	PUNCT
eurjchem-1346	564	30	gore	gore	PROPN
eurjchem-1346	564	31	,	,	PUNCT
eurjchem-1346	564	32	m.	m.	NOUN
eurjchem-1346	564	33	;	;	PUNCT
eurjchem-1346	564	34	desai	desai	PROPN
eurjchem-1346	564	35	,	,	PUNCT
eurjchem-1346	564	36	a.	a.	NOUN
eurjchem-1346	564	37	a.	a.	PROPN
eurjchem-1346	564	38	;	;	PUNCT
eurjchem-1346	564	39	patnaik	patnaik	PROPN
eurjchem-1346	564	40	,	,	PUNCT
eurjchem-1346	564	41	a.	a.	PROPN
eurjchem-1346	564	42	;	;	PUNCT
eurjchem-1346	564	43	xiong	xiong	PROPN
eurjchem-1346	564	44	,	,	PUNCT
eurjchem-1346	564	45	h.	h.	PROPN
eurjchem-1346	564	46	q.	q.	PROPN
eurjchem-1346	564	47	j.	j.	PROPN
eurjchem-1346	564	48	clin	clin	PROPN
eurjchem-1346	564	49	.	.	PUNCT
eurjchem-1346	565	1	oncol	oncol	ADJ
eurjchem-1346	565	2	.	.	PUNCT
eurjchem-1346	566	1	2006	2006	NUM
eurjchem-1346	566	2	,	,	PUNCT
eurjchem-1346	566	3	24(16	24(16	NUM
eurjchem-1346	566	4	)	)	PUNCT
eurjchem-1346	566	5	,	,	PUNCT
eurjchem-1346	566	6	2505‐2512	2505‐2512	NUM
eurjchem-1346	566	7	.	.	PUNCT
eurjchem-1346	567	1	[	[	X
eurjchem-1346	567	2	20	20	NUM
eurjchem-1346	567	3	]	]	PUNCT
eurjchem-1346	567	4	.	.	PUNCT
eurjchem-1346	568	1	king	king	PROPN
eurjchem-1346	568	2	,	,	PUNCT
eurjchem-1346	568	3	a.	a.	PROPN
eurjchem-1346	568	4	j.	j.	PROPN
eurjchem-1346	568	5	;	;	PUNCT
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eurjchem-1346	568	7	,	,	PUNCT
eurjchem-1346	568	8	d.	d.	PROPN
eurjchem-1346	568	9	r.	r.	PROPN
eurjchem-1346	568	10	;	;	PUNCT
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eurjchem-1346	568	12	,	,	PUNCT
eurjchem-1346	568	13	r.	r.	PROPN
eurjchem-1346	568	14	s.	s.	PROPN
eurjchem-1346	568	15	;	;	PUNCT
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eurjchem-1346	568	17	,	,	PUNCT
eurjchem-1346	568	18	m.	m.	NOUN
eurjchem-1346	568	19	l.	l.	PROPN
eurjchem-1346	568	20	;	;	PUNCT
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eurjchem-1346	568	22	,	,	PUNCT
eurjchem-1346	568	23	h.	h.	PROPN
eurjchem-1346	568	24	t.	t.	PROPN
eurjchem-1346	568	25	;	;	PUNCT
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eurjchem-1346	568	27	,	,	PUNCT
eurjchem-1346	568	28	s.	s.	PROPN
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eurjchem-1346	568	30	;	;	PUNCT
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eurjchem-1346	569	2	,	,	PUNCT
eurjchem-1346	569	3	r.	r.	PROPN
eurjchem-1346	569	4	;	;	PUNCT
eurjchem-1346	569	5	rusnak	rusnak	PROPN
eurjchem-1346	569	6	,	,	PUNCT
eurjchem-1346	569	7	d.	d.	PROPN
eurjchem-1346	569	8	w.	w.	PROPN
eurjchem-1346	569	9	;	;	PUNCT
eurjchem-1346	569	10	takle	takle	PROPN
eurjchem-1346	569	11	,	,	PUNCT
eurjchem-1346	569	12	a.	a.	PROPN
eurjchem-1346	569	13	k.	k.	PROPN
eurjchem-1346	569	14	;	;	PUNCT
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eurjchem-1346	569	16	,	,	PUNCT
eurjchem-1346	569	17	d.	d.	PROPN
eurjchem-1346	569	18	m.	m.	PROPN
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eurjchem-1346	569	20	res	re	NOUN
eurjchem-1346	569	21	.	.	PUNCT
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eurjchem-1346	569	23	,	,	PUNCT
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eurjchem-1346	569	25	)	)	PUNCT
eurjchem-1346	569	26	,	,	PUNCT
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eurjchem-1346	569	28	.	.	PUNCT
eurjchem-1346	570	1	[	[	X
eurjchem-1346	570	2	21	21	NUM
eurjchem-1346	570	3	]	]	PUNCT
eurjchem-1346	570	4	.	.	PUNCT
eurjchem-1346	571	1	el‐nassan	el‐nassan	PROPN
eurjchem-1346	571	2	,	,	PUNCT
eurjchem-1346	571	3	h.	h.	PROPN
eurjchem-1346	571	4	b.	b.	PROPN
eurjchem-1346	571	5	eur	eur	PROPN
eurjchem-1346	571	6	.	.	PUNCT
eurjchem-1346	572	1	j.	j.	PROPN
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eurjchem-1346	572	3	.	.	PROPN
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eurjchem-1346	572	5	.	.	PUNCT
eurjchem-1346	573	1	2014	2014	NUM
eurjchem-1346	573	2	,	,	PUNCT
eurjchem-1346	573	3	72	72	NUM
eurjchem-1346	573	4	,	,	PUNCT
eurjchem-1346	573	5	170‐205	170‐205	NUM
eurjchem-1346	573	6	.	.	PUNCT
eurjchem-1346	574	1	[	[	X
eurjchem-1346	574	2	22	22	NUM
eurjchem-1346	574	3	]	]	PUNCT
eurjchem-1346	574	4	.	.	PUNCT
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eurjchem-1346	575	2	,	,	PUNCT
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eurjchem-1346	575	4	j.	j.	PROPN
eurjchem-1346	575	5	l.	l.	PROPN
eurjchem-1346	575	6	j.	j.	PROPN
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eurjchem-1346	575	8	.	.	PROPN
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eurjchem-1346	575	10	.	.	PUNCT
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eurjchem-1346	576	2	,	,	PUNCT
eurjchem-1346	576	3	50	50	NUM
eurjchem-1346	576	4	(	(	PUNCT
eurjchem-1346	576	5	3	3	NUM
eurjchem-1346	576	6	)	)	PUNCT
eurjchem-1346	576	7	,	,	PUNCT
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eurjchem-1346	576	9	.	.	PUNCT
eurjchem-1346	577	1	[	[	X
eurjchem-1346	577	2	23	23	NUM
eurjchem-1346	577	3	]	]	PUNCT
eurjchem-1346	577	4	.	.	PUNCT
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eurjchem-1346	578	2	,	,	PUNCT
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eurjchem-1346	578	6	.	.	PUNCT
eurjchem-1346	579	1	methods	method	NOUN
eurjchem-1346	579	2	1983	1983	NUM
eurjchem-1346	579	3	,	,	PUNCT
eurjchem-1346	579	4	65(1	65(1	NOUN
eurjchem-1346	579	5	)	)	PUNCT
eurjchem-1346	579	6	,	,	PUNCT
eurjchem-1346	579	7	55‐63	55‐63	NUM
eurjchem-1346	579	8	.	.	PUNCT
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eurjchem-1346	580	2	24	24	NUM
eurjchem-1346	580	3	]	]	PUNCT
eurjchem-1346	580	4	.	.	PUNCT
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eurjchem-1346	581	2	,	,	PUNCT
eurjchem-1346	581	3	m.	m.	PROPN
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eurjchem-1346	581	5	;	;	PUNCT
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eurjchem-1346	581	7	,	,	PUNCT
eurjchem-1346	581	8	s.	s.	PROPN
eurjchem-1346	581	9	e.	e.	PROPN
eurjchem-1346	581	10	;	;	PUNCT
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eurjchem-1346	581	12	,	,	PUNCT
eurjchem-1346	581	13	k.	k.	PROPN
eurjchem-1346	581	14	j.	j.	PROPN
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eurjchem-1346	581	16	.	.	PUNCT
eurjchem-1346	582	1	methods	method	NOUN
eurjchem-1346	582	2	1989	1989	NUM
eurjchem-1346	582	3	,	,	PUNCT
eurjchem-1346	582	4	119(2	119(2	NUM
eurjchem-1346	582	5	)	)	PUNCT
eurjchem-1346	582	6	,	,	PUNCT
eurjchem-1346	582	7	203‐210	203‐210	PROPN
eurjchem-1346	582	8	.	.	PUNCT
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eurjchem-1346	583	2	25	25	NUM
eurjchem-1346	583	3	]	]	PUNCT
eurjchem-1346	583	4	.	.	PUNCT
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eurjchem-1346	584	2	,	,	PUNCT
eurjchem-1346	584	3	j.	j.	PROPN
eurjchem-1346	584	4	;	;	PUNCT
eurjchem-1346	584	5	xie	xie	PROPN
eurjchem-1346	584	6	,	,	PUNCT
eurjchem-1346	584	7	p.	p.	NOUN
eurjchem-1346	584	8	;	;	PUNCT
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eurjchem-1346	584	10	,	,	PUNCT
eurjchem-1346	584	11	c.	c.	NOUN
eurjchem-1346	584	12	;	;	PUNCT
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eurjchem-1346	584	14	,	,	PUNCT
eurjchem-1346	584	15	g.	g.	PROPN
eurjchem-1346	584	16	;	;	PUNCT
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eurjchem-1346	584	18	,	,	PUNCT
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eurjchem-1346	584	20	;	;	PUNCT
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eurjchem-1346	584	24	;	;	PUNCT
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eurjchem-1346	584	26	,	,	PUNCT
eurjchem-1346	584	27	q.	q.	PROPN
eurjchem-1346	584	28	;	;	PUNCT
eurjchem-1346	584	29	herlyn	herlyn	NOUN
eurjchem-1346	584	30	,	,	PUNCT
eurjchem-1346	584	31	m.	m.	NOUN
eurjchem-1346	584	32	;	;	PUNCT
eurjchem-1346	584	33	winkler	winkler	NOUN
eurjchem-1346	584	34	,	,	PUNCT
eurjchem-1346	584	35	j.	j.	PROPN
eurjchem-1346	584	36	;	;	PUNCT
eurjchem-1346	584	37	marmorstein	marmorstein	PROPN
eurjchem-1346	584	38	,	,	PUNCT
eurjchem-1346	584	39	r.	r.	PROPN
eurjchem-1346	584	40	j.	j.	PROPN
eurjchem-1346	584	41	med	med	PROPN
eurjchem-1346	584	42	.	.	PROPN
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eurjchem-1346	584	44	.	.	PUNCT
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eurjchem-1346	585	2	,	,	PUNCT
eurjchem-1346	585	3	55(11	55(11	NUM
eurjchem-1346	585	4	)	)	PUNCT
eurjchem-1346	585	5	,	,	PUNCT
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eurjchem-1346	585	7	.	.	PUNCT
eurjchem-1346	586	1	[	[	X
eurjchem-1346	586	2	26	26	NUM
eurjchem-1346	586	3	]	]	PUNCT
eurjchem-1346	586	4	.	.	PUNCT
eurjchem-1346	587	1	kim	kim	PROPN
eurjchem-1346	587	2	,	,	PUNCT
eurjchem-1346	587	3	j.	j.	PROPN
eurjchem-1346	587	4	e.	e.	PROPN
eurjchem-1346	587	5	;	;	PUNCT
eurjchem-1346	587	6	leung	leung	PROPN
eurjchem-1346	587	7	,	,	PUNCT
eurjchem-1346	587	8	e.	e.	PROPN
eurjchem-1346	587	9	;	;	PUNCT
eurjchem-1346	587	10	baguley	baguley	PROPN
eurjchem-1346	587	11	,	,	PUNCT
eurjchem-1346	587	12	b.	b.	PROPN
eurjchem-1346	587	13	c.	c.	PROPN
eurjchem-1346	587	14	;	;	PUNCT
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eurjchem-1346	587	16	,	,	PUNCT
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eurjchem-1346	587	18	j.	j.	PROPN
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eurjchem-1346	587	20	.	.	PUNCT
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eurjchem-1346	588	2	.	.	PUNCT
eurjchem-1346	589	1	2013	2013	NUM
eurjchem-1346	589	2	,	,	PUNCT
eurjchem-1346	589	3	4(97	4(97	NUM
eurjchem-1346	589	4	)	)	PUNCT
eurjchem-1346	589	5	,	,	PUNCT
eurjchem-1346	589	6	1‐8	1‐8	NOUN
eurjchem-1346	589	7	.	.	PUNCT
eurjchem-1346	590	1	[	[	X
eurjchem-1346	590	2	27	27	NUM
eurjchem-1346	590	3	]	]	PUNCT
eurjchem-1346	590	4	.	.	PUNCT
eurjchem-1346	590	5	molecular	molecular	ADJ
eurjchem-1346	590	6	operating	operating	NOUN
eurjchem-1346	590	7	environment	environment	NOUN
eurjchem-1346	590	8	(	(	PUNCT
eurjchem-1346	590	9	moe	moe	NOUN
eurjchem-1346	590	10	)	)	PUNCT
eurjchem-1346	590	11	,	,	PUNCT
eurjchem-1346	590	12	chemical	chemical	NOUN
eurjchem-1346	590	13	computing	computing	NOUN
eurjchem-1346	590	14	group	group	NOUN
eurjchem-1346	590	15	,	,	PUNCT
eurjchem-1346	590	16	canada	canada	PROPN
eurjchem-1346	590	17	,	,	PUNCT
eurjchem-1346	590	18	https://www.chemcomp.com/moe‐molecular	https://www.chemcomp.com/moe‐molecular	PROPN
eurjchem-1346	590	19	_	_	NOUN
eurjchem-1346	590	20	operating_environment.htm	operating_environment.htm	NOUN
eurjchem-1346	590	21	.	.	PUNCT
eurjchem-1346	591	1	[	[	X
eurjchem-1346	591	2	28	28	NUM
eurjchem-1346	591	3	]	]	PUNCT
eurjchem-1346	591	4	.	.	PUNCT
eurjchem-1346	592	1	tsai	tsai	PROPN
eurjchem-1346	592	2	,	,	PUNCT
eurjchem-1346	592	3	j.	j.	PROPN
eurjchem-1346	592	4	;	;	PUNCT
eurjchem-1346	592	5	lee	lee	PROPN
eurjchem-1346	592	6	,	,	PUNCT
eurjchem-1346	592	7	j.	j.	PROPN
eurjchem-1346	592	8	t.	t.	PROPN
eurjchem-1346	592	9	;	;	PUNCT
eurjchem-1346	592	10	wang	wang	PROPN
eurjchem-1346	592	11	,	,	PUNCT
eurjchem-1346	592	12	w.	w.	PROPN
eurjchem-1346	592	13	;	;	PUNCT
eurjchem-1346	592	14	zhang	zhang	PROPN
eurjchem-1346	592	15	,	,	PUNCT
eurjchem-1346	592	16	j.	j.	PROPN
eurjchem-1346	592	17	;	;	PUNCT
eurjchem-1346	592	18	cho	cho	PROPN
eurjchem-1346	592	19	,	,	PUNCT
eurjchem-1346	592	20	h.	h.	PROPN
eurjchem-1346	592	21	;	;	PUNCT
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eurjchem-1346	592	23	,	,	PUNCT
eurjchem-1346	592	24	s.	s.	PROPN
eurjchem-1346	592	25	;	;	PUNCT
eurjchem-1346	592	26	bremer	bremer	X
eurjchem-1346	592	27	,	,	PUNCT
eurjchem-1346	592	28	r.	r.	PROPN
eurjchem-1346	592	29	;	;	PUNCT
eurjchem-1346	592	30	gillette	gillette	PROPN
eurjchem-1346	592	31	,	,	PUNCT
eurjchem-1346	592	32	s.	s.	PROPN
eurjchem-1346	592	33	;	;	PUNCT
eurjchem-1346	592	34	kong	kong	PROPN
eurjchem-1346	592	35	,	,	PUNCT
eurjchem-1346	592	36	j.	j.	PROPN
eurjchem-1346	592	37	;	;	PUNCT
eurjchem-1346	592	38	haass	haass	PROPN
eurjchem-1346	592	39	,	,	PUNCT
eurjchem-1346	592	40	n.	n.	PROPN
eurjchem-1346	592	41	k.	k.	PROPN
eurjchem-1346	592	42	proc	proc	PROPN
eurjchem-1346	592	43	.	.	PUNCT
eurjchem-1346	593	1	natl	natl	PROPN
eurjchem-1346	593	2	.	.	PUNCT
eurjchem-1346	594	1	acad	acad	PROPN
eurjchem-1346	594	2	.	.	PUNCT
eurjchem-1346	595	1	sci	sci	PROPN
eurjchem-1346	595	2	.	.	PROPN
eurjchem-1346	595	3	2008	2008	NUM
eurjchem-1346	595	4	,	,	PUNCT
eurjchem-1346	595	5	105(8	105(8	NUM
eurjchem-1346	595	6	)	)	PUNCT
eurjchem-1346	595	7	,	,	PUNCT
eurjchem-1346	595	8	3041‐3046	3041‐3046	NUM
eurjchem-1346	595	9	.	.	PUNCT
eurjchem-1346	596	1	[	[	X
eurjchem-1346	596	2	29	29	NUM
eurjchem-1346	596	3	]	]	PUNCT
eurjchem-1346	596	4	.	.	PUNCT
eurjchem-1346	597	1	leese	leese	PROPN
eurjchem-1346	597	2	,	,	PUNCT
eurjchem-1346	597	3	c.	c.	PROPN
eurjchem-1346	597	4	;	;	PUNCT
eurjchem-1346	597	5	rydon	rydon	PROPN
eurjchem-1346	597	6	,	,	PUNCT
eurjchem-1346	597	7	h.	h.	PROPN
eurjchem-1346	597	8	j.	j.	PROPN
eurjchem-1346	597	9	chem	chem	PROPN
eurjchem-1346	597	10	.	.	PUNCT
eurjchem-1346	598	1	soc	soc	PROPN
eurjchem-1346	598	2	.	.	PUNCT
eurjchem-1346	599	1	1955	1955	NUM
eurjchem-1346	599	2	,	,	PUNCT
eurjchem-1346	599	3	303‐309	303‐309	NUM
eurjchem-1346	599	4	.	.	PUNCT
eurjchem-1346	600	1	[	[	X
eurjchem-1346	600	2	30	30	NUM
eurjchem-1346	600	3	]	]	PUNCT
eurjchem-1346	600	4	.	.	PUNCT
eurjchem-1346	600	5	bahadur	bahadur	PROPN
eurjchem-1346	600	6	,	,	PUNCT
eurjchem-1346	600	7	s.	s.	PROPN
eurjchem-1346	600	8	;	;	PUNCT
eurjchem-1346	600	9	pandey	pandey	PROPN
eurjchem-1346	600	10	,	,	PUNCT
eurjchem-1346	600	11	k.	k.	PROPN
eurjchem-1346	600	12	indian	indian	PROPN
eurjchem-1346	600	13	chem	chem	PROPN
eurjchem-1346	600	14	.	.	PUNCT
eurjchem-1346	601	1	soc	soc	PROPN
eurjchem-1346	601	2	.	.	PUNCT
eurjchem-1346	602	1	1980	1980	NUM
eurjchem-1346	602	2	,	,	PUNCT
eurjchem-1346	602	3	57(4	57(4	NUM
eurjchem-1346	602	4	)	)	PUNCT
eurjchem-1346	602	5	,	,	PUNCT
eurjchem-1346	602	6	447‐448	447‐448	NUM
eurjchem-1346	602	7	.	.	PUNCT
eurjchem-1346	603	1	[	[	X
eurjchem-1346	603	2	31	31	NUM
eurjchem-1346	603	3	]	]	PUNCT
eurjchem-1346	603	4	.	.	PUNCT
eurjchem-1346	603	5	westphal	westphal	PROPN
eurjchem-1346	603	6	,	,	PUNCT
eurjchem-1346	603	7	g.	g.	PROPN
eurjchem-1346	603	8	;	;	PUNCT
eurjchem-1346	603	9	wasicki	wasicki	PROPN
eurjchem-1346	603	10	,	,	PUNCT
eurjchem-1346	603	11	h.	h.	PROPN
eurjchem-1346	603	12	;	;	PUNCT
eurjchem-1346	603	13	zielinski	zielinski	PROPN
eurjchem-1346	603	14	,	,	PUNCT
eurjchem-1346	603	15	u.	u.	PROPN
eurjchem-1346	603	16	;	;	PUNCT
eurjchem-1346	603	17	weber	weber	PROPN
eurjchem-1346	603	18	,	,	PUNCT
eurjchem-1346	603	19	f.	f.	PROPN
eurjchem-1346	603	20	;	;	PUNCT
eurjchem-1346	603	21	tonew	tonew	ADV
eurjchem-1346	603	22	,	,	PUNCT
eurjchem-1346	603	23	m.	m.	NOUN
eurjchem-1346	603	24	;	;	PUNCT
eurjchem-1346	603	25	tonew	tonew	ADV
eurjchem-1346	603	26	,	,	PUNCT
eurjchem-1346	603	27	e.	e.	PROPN
eurjchem-1346	603	28	pharmazie	pharmazie	PROPN
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eurjchem-1346	603	30	,	,	PUNCT
eurjchem-1346	603	31	32(10	32(10	NUM
eurjchem-1346	603	32	)	)	PUNCT
eurjchem-1346	603	33	,	,	PUNCT
eurjchem-1346	603	34	570	570	NUM
eurjchem-1346	603	35	.	.	PUNCT
eurjchem-1346	604	1	[	[	X
eurjchem-1346	604	2	32	32	NUM
eurjchem-1346	604	3	]	]	PUNCT
eurjchem-1346	604	4	.	.	PUNCT
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eurjchem-1346	605	2	,	,	PUNCT
eurjchem-1346	605	3	g.	g.	PROPN
eurjchem-1346	605	4	;	;	PUNCT
eurjchem-1346	605	5	occelli	occelli	PROPN
eurjchem-1346	605	6	,	,	PUNCT
eurjchem-1346	605	7	e.	e.	PROPN
eurjchem-1346	605	8	;	;	PUNCT
eurjchem-1346	605	9	toja	toja	PROPN
eurjchem-1346	605	10	,	,	PUNCT
eurjchem-1346	605	11	e.	e.	PROPN
eurjchem-1346	605	12	;	;	PUNCT
eurjchem-1346	605	13	barone	barone	PROPN
eurjchem-1346	605	14	,	,	PUNCT
eurjchem-1346	605	15	d.	d.	PROPN
eurjchem-1346	605	16	;	;	PUNCT
eurjchem-1346	605	17	corsico	corsico	NOUN
eurjchem-1346	605	18	,	,	PUNCT
eurjchem-1346	605	19	n.	n.	NOUN
eurjchem-1346	605	20	;	;	PUNCT
eurjchem-1346	605	21	gallico	gallico	PROPN
eurjchem-1346	605	22	,	,	PUNCT
eurjchem-1346	605	23	l.	l.	PROPN
eurjchem-1346	605	24	;	;	PUNCT
eurjchem-1346	605	25	luzzani	luzzani	PROPN
eurjchem-1346	605	26	,	,	PUNCT
eurjchem-1346	605	27	f.	f.	PROPN
eurjchem-1346	605	28	j.	j.	PROPN
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eurjchem-1346	605	30	.	.	PROPN
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eurjchem-1346	605	32	.	.	PUNCT
eurjchem-1346	606	1	1988	1988	NUM
eurjchem-1346	606	2	,	,	PUNCT
eurjchem-1346	606	3	31(6	31(6	NUM
eurjchem-1346	606	4	)	)	PUNCT
eurjchem-1346	606	5	,	,	PUNCT
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eurjchem-1346	606	7	.	.	PUNCT
eurjchem-1346	607	1	[	[	X
eurjchem-1346	607	2	33	33	NUM
eurjchem-1346	607	3	]	]	PUNCT
eurjchem-1346	607	4	.	.	PUNCT
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eurjchem-1346	608	2	,	,	PUNCT
eurjchem-1346	608	3	r.	r.	PROPN
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eurjchem-1346	608	5	.	.	PUNCT
eurjchem-1346	609	1	biophys	biophy	NOUN
eurjchem-1346	609	2	.	.	PUNCT
eurjchem-1346	610	1	res	re	NOUN
eurjchem-1346	610	2	.	.	PUNCT
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eurjchem-1346	611	2	.	.	PUNCT
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eurjchem-1346	612	2	,	,	PUNCT
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eurjchem-1346	612	4	)	)	PUNCT
eurjchem-1346	612	5	,	,	PUNCT
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eurjchem-1346	612	7	.	.	PUNCT
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eurjchem-1346	613	3	]	]	PUNCT
eurjchem-1346	613	4	.	.	PUNCT
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eurjchem-1346	614	2	,	,	PUNCT
eurjchem-1346	614	3	x.	x.	PROPN
eurjchem-1346	614	4	;	;	PUNCT
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eurjchem-1346	614	6	,	,	PUNCT
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eurjchem-1346	614	8	j.	j.	PROPN
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eurjchem-1346	615	2	,	,	PUNCT
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eurjchem-1346	615	4	)	)	PUNCT
eurjchem-1346	615	5	,	,	PUNCT
eurjchem-1346	615	6	7332‐7341	7332‐7341	NOUN
eurjchem-1346	615	7	.	.	PUNCT