id sid tid token lemma pos eurjchem-1667 1 1 untitled untitle VERB eurjchem-1667 1 2 european european PROPN eurjchem-1667 1 3 journal journal PROPN eurjchem-1667 1 4 of of ADP eurjchem-1667 1 5 chemistry chemistry NOUN eurjchem-1667 1 6 8 8 NUM eurjchem-1667 1 7 ( ( PUNCT eurjchem-1667 1 8 4 4 NUM eurjchem-1667 1 9 ) ) PUNCT eurjchem-1667 1 10 ( ( PUNCT eurjchem-1667 1 11 2017 2017 NUM eurjchem-1667 1 12 ) ) PUNCT eurjchem-1667 1 13 430‐433 430‐433 PROPN eurjchem-1667 1 14 european european PROPN eurjchem-1667 1 15 journal journal PROPN eurjchem-1667 1 16 of of ADP eurjchem-1667 1 17 chemistry chemistry NOUN eurjchem-1667 1 18 issn issn PROPN eurjchem-1667 1 19 2153‐2249 2153‐2249 PROPN eurjchem-1667 1 20 ( ( PUNCT eurjchem-1667 1 21 print print NOUN eurjchem-1667 1 22 ) ) PUNCT eurjchem-1667 1 23 / / SYM eurjchem-1667 1 24 issn issn PROPN eurjchem-1667 1 25 2153‐2257 2153‐2257 NUM eurjchem-1667 1 26 ( ( PUNCT eurjchem-1667 1 27 online online ADJ eurjchem-1667 1 28 ) ) PUNCT eurjchem-1667 1 29   NOUN eurjchem-1667 1 30 2017 2017 NUM eurjchem-1667 1 31 atlanta atlanta PROPN eurjchem-1667 1 32 publishing publishing PROPN eurjchem-1667 1 33 house house PROPN eurjchem-1667 1 34 llc llc PROPN eurjchem-1667 1 35 ‐ ‐ PUNCT eurjchem-1667 1 36 all all DET eurjchem-1667 1 37 rights right NOUN eurjchem-1667 1 38 reserved reserve VERB eurjchem-1667 1 39 ‐ ‐ NOUN eurjchem-1667 1 40 printed print VERB eurjchem-1667 1 41 in in ADP eurjchem-1667 1 42 the the DET eurjchem-1667 1 43 usa usa PROPN eurjchem-1667 1 44 http://dx.doi.org/10.5155/eurjchem.8.4.430-433.1667 http://dx.doi.org/10.5155/eurjchem.8.4.430-433.1667 PROPN eurjchem-1667 1 45 european european PROPN eurjchem-1667 1 46 journal journal PROPN eurjchem-1667 1 47 of of ADP eurjchem-1667 1 48 chemistry chemistry PROPN eurjchem-1667 1 49 journal journal PROPN eurjchem-1667 1 50 webpage webpage NOUN eurjchem-1667 1 51 : : PUNCT eurjchem-1667 1 52 www.eurjchem.com www.eurjchem.com X eurjchem-1667 1 53 quality quality NOUN eurjchem-1667 1 54 by by ADP eurjchem-1667 1 55 design design NOUN eurjchem-1667 1 56 ( ( PUNCT eurjchem-1667 1 57 qbd qbd NOUN eurjchem-1667 1 58 ) ) PUNCT eurjchem-1667 1 59 and and CCONJ eurjchem-1667 1 60 process process VERB eurjchem-1667 1 61 analytical analytical ADJ eurjchem-1667 1 62 technology technology NOUN eurjchem-1667 1 63 ( ( PUNCT eurjchem-1667 1 64 pat pat NOUN eurjchem-1667 1 65 ) ) PUNCT eurjchem-1667 1 66 applications application NOUN eurjchem-1667 1 67 in in ADP eurjchem-1667 1 68 pharmaceutical pharmaceutical NOUN eurjchem-1667 1 69 industry industry NOUN eurjchem-1667 1 70 selda selda NOUN eurjchem-1667 1 71 dogan dogan PROPN eurjchem-1667 1 72 calhan calhan PROPN eurjchem-1667 1 73 * * PUNCT eurjchem-1667 1 74 , , PUNCT eurjchem-1667 1 75 ebru ebru NOUN eurjchem-1667 1 76 derici derici NOUN eurjchem-1667 1 77 eker eker NOUN eurjchem-1667 1 78 and and CCONJ eurjchem-1667 1 79 nefise nefise PROPN eurjchem-1667 1 80 ozlen ozlen VERB eurjchem-1667 1 81 sahin sahin PROPN eurjchem-1667 1 82 department department PROPN eurjchem-1667 1 83 of of ADP eurjchem-1667 1 84 pharmaceutical pharmaceutical NOUN eurjchem-1667 1 85 biotechnology biotechnology NOUN eurjchem-1667 1 86 , , PUNCT eurjchem-1667 1 87 faculty faculty NOUN eurjchem-1667 1 88 of of ADP eurjchem-1667 1 89 pharmacy pharmacy NOUN eurjchem-1667 1 90 , , PUNCT eurjchem-1667 1 91 mersin mersin PROPN eurjchem-1667 1 92 university university PROPN eurjchem-1667 1 93 , , PUNCT eurjchem-1667 1 94 33169 33169 NUM eurjchem-1667 1 95 , , PUNCT eurjchem-1667 1 96 mersin mersin PROPN eurjchem-1667 1 97 , , PUNCT eurjchem-1667 1 98 turkey turkey NOUN eurjchem-1667 1 99 * * PUNCT eurjchem-1667 1 100 corresponding correspond VERB eurjchem-1667 1 101 author author NOUN eurjchem-1667 1 102 at at ADP eurjchem-1667 1 103 : : PUNCT eurjchem-1667 1 104 department department NOUN eurjchem-1667 1 105 of of ADP eurjchem-1667 1 106 pharmaceutical pharmaceutical NOUN eurjchem-1667 1 107 biotechnology biotechnology NOUN eurjchem-1667 1 108 , , PUNCT eurjchem-1667 1 109 faculty faculty NOUN eurjchem-1667 1 110 of of ADP eurjchem-1667 1 111 pharmacy pharmacy NOUN eurjchem-1667 1 112 , , PUNCT eurjchem-1667 1 113 mersin mersin PROPN eurjchem-1667 1 114 university university PROPN eurjchem-1667 1 115 , , PUNCT eurjchem-1667 1 116 33169 33169 NUM eurjchem-1667 1 117 , , PUNCT eurjchem-1667 1 118 mersin mersin PROPN eurjchem-1667 1 119 , , PUNCT eurjchem-1667 1 120 turkey turkey PROPN eurjchem-1667 1 121 . . PUNCT eurjchem-1667 2 1 tel tel PROPN eurjchem-1667 2 2 . . PUNCT eurjchem-1667 2 3 : : PUNCT eurjchem-1667 3 1 +90.324.3412815 +90.324.3412815 X eurjchem-1667 3 2 . . X eurjchem-1667 3 3 fax fax NOUN eurjchem-1667 3 4 : : PUNCT eurjchem-1667 3 5 +90.324.3413022 +90.324.3413022 PROPN eurjchem-1667 3 6 . . PUNCT eurjchem-1667 3 7 e‐mail e‐mail PUNCT eurjchem-1667 4 1 address address NOUN eurjchem-1667 4 2 : : PUNCT eurjchem-1667 4 3 seldadgn@mersin.edu.tr seldadgn@mersin.edu.tr PROPN eurjchem-1667 4 4 ( ( PUNCT eurjchem-1667 4 5 s.d s.d PROPN eurjchem-1667 4 6 . . PROPN eurjchem-1667 4 7 calhan calhan PROPN eurjchem-1667 4 8 ) ) PUNCT eurjchem-1667 4 9 . . PUNCT eurjchem-1667 5 1 review review VERB eurjchem-1667 5 2 information information NOUN eurjchem-1667 5 3 abstract abstract ADJ eurjchem-1667 5 4 doi doi PROPN eurjchem-1667 5 5 : : PUNCT eurjchem-1667 5 6     SPACE eurjchem-1667 5 7 10.5155 10.5155 NUM eurjchem-1667 5 8 / / SYM eurjchem-1667 5 9 eurjchem.8.4.430 eurjchem.8.4.430 PROPN eurjchem-1667 5 10 - - PUNCT eurjchem-1667 5 11 433.1667 433.1667 NUM eurjchem-1667 5 12 received receive VERB eurjchem-1667 5 13 : : PUNCT eurjchem-1667 5 14 01 01 NUM eurjchem-1667 5 15 november november PROPN eurjchem-1667 5 16 2017 2017 NUM eurjchem-1667 5 17 received receive VERB eurjchem-1667 5 18 in in ADP eurjchem-1667 5 19 revised revise VERB eurjchem-1667 5 20 form form NOUN eurjchem-1667 5 21 : : PUNCT eurjchem-1667 5 22 14 14 NUM eurjchem-1667 5 23 november november PROPN eurjchem-1667 5 24 2017 2017 NUM eurjchem-1667 5 25 accepted accept VERB eurjchem-1667 5 26 : : PUNCT eurjchem-1667 5 27 14 14 NUM eurjchem-1667 5 28 november november PROPN eurjchem-1667 5 29 2017 2017 NUM eurjchem-1667 5 30 published publish VERB eurjchem-1667 5 31 online online ADV eurjchem-1667 5 32 : : PUNCT eurjchem-1667 5 33 31 31 NUM eurjchem-1667 5 34 december december PROPN eurjchem-1667 5 35 2017 2017 NUM eurjchem-1667 5 36 printed print VERB eurjchem-1667 5 37 : : PUNCT eurjchem-1667 5 38 31 31 NUM eurjchem-1667 5 39 december december PROPN eurjchem-1667 5 40 2017 2017 NUM eurjchem-1667 5 41     SPACE eurjchem-1667 5 42 quality quality NOUN eurjchem-1667 5 43 by by ADP eurjchem-1667 5 44 design design NOUN eurjchem-1667 5 45 ( ( PUNCT eurjchem-1667 5 46 qbd qbd PROPN eurjchem-1667 5 47 ) ) PUNCT eurjchem-1667 5 48 for for ADP eurjchem-1667 5 49 the the DET eurjchem-1667 5 50 pharmaceutical pharmaceutical ADJ eurjchem-1667 5 51 industry industry NOUN eurjchem-1667 5 52 includes include VERB eurjchem-1667 5 53 the the DET eurjchem-1667 5 54 design design NOUN eurjchem-1667 5 55 , , PUNCT eurjchem-1667 5 56 development development NOUN eurjchem-1667 5 57 and and CCONJ eurjchem-1667 5 58 production production NOUN eurjchem-1667 5 59 control control NOUN eurjchem-1667 5 60 of of ADP eurjchem-1667 5 61 products product NOUN eurjchem-1667 5 62 and and CCONJ eurjchem-1667 5 63 production production NOUN eurjchem-1667 5 64 processes process NOUN eurjchem-1667 5 65 from from ADP eurjchem-1667 5 66 the the DET eurjchem-1667 5 67 beginning beginning NOUN eurjchem-1667 5 68 to to ADP eurjchem-1667 5 69 the the DET eurjchem-1667 5 70 end end NOUN eurjchem-1667 5 71 of of ADP eurjchem-1667 5 72 the the DET eurjchem-1667 5 73 product product NOUN eurjchem-1667 5 74 development development NOUN eurjchem-1667 5 75 phase phase NOUN eurjchem-1667 5 76 for for ADP eurjchem-1667 5 77 ensuring ensure VERB eurjchem-1667 5 78 the the DET eurjchem-1667 5 79 consistent consistent ADJ eurjchem-1667 5 80 quality quality NOUN eurjchem-1667 5 81 of of ADP eurjchem-1667 5 82 a a DET eurjchem-1667 5 83 pharmaceutical pharmaceutical ADJ eurjchem-1667 5 84 product product NOUN eurjchem-1667 5 85 . . PUNCT eurjchem-1667 6 1 the the DET eurjchem-1667 6 2 qbd qbd PROPN eurjchem-1667 6 3 is be AUX eurjchem-1667 6 4 a a DET eurjchem-1667 6 5 systematic systematic ADJ eurjchem-1667 6 6 scientific scientific ADJ eurjchem-1667 6 7 approach approach NOUN eurjchem-1667 6 8 aimed aim VERB eurjchem-1667 6 9 at at ADP eurjchem-1667 6 10 meeting meet VERB eurjchem-1667 6 11 the the DET eurjchem-1667 6 12 needs need NOUN eurjchem-1667 6 13 of of ADP eurjchem-1667 6 14 the the DET eurjchem-1667 6 15 patient patient NOUN eurjchem-1667 6 16 in in ADP eurjchem-1667 6 17 the the DET eurjchem-1667 6 18 desired desire VERB eurjchem-1667 6 19 and and CCONJ eurjchem-1667 6 20 targeted target VERB eurjchem-1667 6 21 quality quality NOUN eurjchem-1667 6 22 and and CCONJ eurjchem-1667 6 23 aiming aim VERB eurjchem-1667 6 24 to to PART eurjchem-1667 6 25 produce produce VERB eurjchem-1667 6 26 the the DET eurjchem-1667 6 27 same same ADJ eurjchem-1667 6 28 quality quality NOUN eurjchem-1667 6 29 pharmaceutical pharmaceutical NOUN eurjchem-1667 6 30 product product NOUN eurjchem-1667 6 31 in in ADP eurjchem-1667 6 32 this this DET eurjchem-1667 6 33 direction direction NOUN eurjchem-1667 6 34 . . PUNCT eurjchem-1667 7 1 process process NOUN eurjchem-1667 7 2 analytical analytical ADJ eurjchem-1667 7 3 technology technology NOUN eurjchem-1667 7 4 , , PUNCT eurjchem-1667 7 5 which which PRON eurjchem-1667 7 6 is be AUX eurjchem-1667 7 7 assessed assess VERB eurjchem-1667 7 8 in in ADP eurjchem-1667 7 9 that that DET eurjchem-1667 7 10 regard regard NOUN eurjchem-1667 7 11 , , PUNCT eurjchem-1667 7 12 is be AUX eurjchem-1667 7 13 part part NOUN eurjchem-1667 7 14 of of ADP eurjchem-1667 7 15 a a DET eurjchem-1667 7 16 design design NOUN eurjchem-1667 7 17 quality quality NOUN eurjchem-1667 7 18 approach approach NOUN eurjchem-1667 7 19 that that PRON eurjchem-1667 7 20 is be AUX eurjchem-1667 7 21 used use VERB eurjchem-1667 7 22 to to PART eurjchem-1667 7 23 design design VERB eurjchem-1667 7 24 , , PUNCT eurjchem-1667 7 25 analyze analyze VERB eurjchem-1667 7 26 , , PUNCT eurjchem-1667 7 27 and and CCONJ eurjchem-1667 7 28 control control NOUN eurjchem-1667 7 29 real‐time real‐time NOUN eurjchem-1667 7 30 measurements measurement NOUN eurjchem-1667 7 31 of of ADP eurjchem-1667 7 32 quality quality NOUN eurjchem-1667 7 33 and and CCONJ eurjchem-1667 7 34 performance performance NOUN eurjchem-1667 7 35 criteria criterion NOUN eurjchem-1667 7 36 for for ADP eurjchem-1667 7 37 raw raw ADJ eurjchem-1667 7 38 and and CCONJ eurjchem-1667 7 39 processed process VERB eurjchem-1667 7 40 materials material NOUN eurjchem-1667 7 41 to to PART eurjchem-1667 7 42 achieve achieve VERB eurjchem-1667 7 43 the the DET eurjchem-1667 7 44 desired desire VERB eurjchem-1667 7 45 final final ADJ eurjchem-1667 7 46 product product NOUN eurjchem-1667 7 47 . . PUNCT eurjchem-1667 8 1 this this DET eurjchem-1667 8 2 scientific scientific ADJ eurjchem-1667 8 3 and and CCONJ eurjchem-1667 8 4 systematic systematic ADJ eurjchem-1667 8 5 approach approach NOUN eurjchem-1667 8 6 to to ADP eurjchem-1667 8 7 pharmaceutical pharmaceutical ADJ eurjchem-1667 8 8 product product NOUN eurjchem-1667 8 9 development development NOUN eurjchem-1667 8 10 , , PUNCT eurjchem-1667 8 11 which which PRON eurjchem-1667 8 12 is be AUX eurjchem-1667 8 13 also also ADV eurjchem-1667 8 14 acknowledged acknowledge VERB eurjchem-1667 8 15 and and CCONJ eurjchem-1667 8 16 supported support VERB eurjchem-1667 8 17 by by ADP eurjchem-1667 8 18 the the DET eurjchem-1667 8 19 health health NOUN eurjchem-1667 8 20 authorities authority NOUN eurjchem-1667 8 21 , , PUNCT eurjchem-1667 8 22 serves serve VERB eurjchem-1667 8 23 to to ADP eurjchem-1667 8 24 the the DET eurjchem-1667 8 25 changing change VERB eurjchem-1667 8 26 and and CCONJ eurjchem-1667 8 27 developing develop VERB eurjchem-1667 8 28 pharmaceutical pharmaceutical ADJ eurjchem-1667 8 29 sector sector NOUN eurjchem-1667 8 30 . . PUNCT eurjchem-1667 9 1 keywords keyword VERB eurjchem-1667 9 2 drug drug NOUN eurjchem-1667 9 3 spectroscopy spectroscopy NOUN eurjchem-1667 9 4 quality quality NOUN eurjchem-1667 9 5 by by ADP eurjchem-1667 9 6 design design NOUN eurjchem-1667 9 7 product product NOUN eurjchem-1667 9 8 development development NOUN eurjchem-1667 9 9 pharmaceutical pharmaceutical NOUN eurjchem-1667 9 10 industry industry NOUN eurjchem-1667 9 11 process process NOUN eurjchem-1667 9 12 analytical analytical ADJ eurjchem-1667 9 13 technology technology NOUN eurjchem-1667 9 14 cite cite VERB eurjchem-1667 9 15 this this PRON eurjchem-1667 9 16 : : PUNCT eurjchem-1667 9 17 eur eur PROPN eurjchem-1667 9 18 . . PUNCT eurjchem-1667 10 1 j. j. PROPN eurjchem-1667 10 2 chem chem PROPN eurjchem-1667 10 3 . . PUNCT eurjchem-1667 11 1 2017 2017 NUM eurjchem-1667 11 2 , , PUNCT eurjchem-1667 11 3 8(4 8(4 NUM eurjchem-1667 11 4 ) ) PUNCT eurjchem-1667 11 5 , , PUNCT eurjchem-1667 11 6 430‐433 430‐433 PROPN eurjchem-1667 11 7 1 1 NUM eurjchem-1667 11 8 . . PUNCT eurjchem-1667 11 9 introduction introduction NOUN eurjchem-1667 11 10 the the DET eurjchem-1667 11 11 struggle struggle NOUN eurjchem-1667 11 12 of of ADP eurjchem-1667 11 13 human human ADJ eurjchem-1667 11 14 beings being NOUN eurjchem-1667 11 15 while while SCONJ eurjchem-1667 11 16 suffering suffer VERB eurjchem-1667 11 17 from from ADP eurjchem-1667 11 18 diseases disease NOUN eurjchem-1667 11 19 , , PUNCT eurjchem-1667 11 20 is be AUX eurjchem-1667 11 21 a a DET eurjchem-1667 11 22 journey journey NOUN eurjchem-1667 11 23 going go VERB eurjchem-1667 11 24 on on ADP eurjchem-1667 11 25 day day NOUN eurjchem-1667 11 26 by by ADP eurjchem-1667 11 27 day day NOUN eurjchem-1667 11 28 from from ADP eurjchem-1667 11 29 the the DET eurjchem-1667 11 30 existence existence NOUN eurjchem-1667 11 31 and and CCONJ eurjchem-1667 11 32 will will AUX eurjchem-1667 11 33 continue continue VERB eurjchem-1667 11 34 as as ADV eurjchem-1667 11 35 long long ADV eurjchem-1667 11 36 as as SCONJ eurjchem-1667 11 37 we we PRON eurjchem-1667 11 38 exist exist VERB eurjchem-1667 11 39 . . PUNCT eurjchem-1667 12 1 during during ADP eurjchem-1667 12 2 this this DET eurjchem-1667 12 3 process process NOUN eurjchem-1667 12 4 , , PUNCT eurjchem-1667 12 5 doctors doctor NOUN eurjchem-1667 12 6 and and CCONJ eurjchem-1667 12 7 pharmacists pharmacist NOUN eurjchem-1667 12 8 are be AUX eurjchem-1667 12 9 members member NOUN eurjchem-1667 12 10 of of ADP eurjchem-1667 12 11 a a DET eurjchem-1667 12 12 professional professional ADJ eurjchem-1667 12 13 group group NOUN eurjchem-1667 12 14 as as ADV eurjchem-1667 12 15 old old ADJ eurjchem-1667 12 16 as as ADP eurjchem-1667 12 17 human human ADJ eurjchem-1667 12 18 history history NOUN eurjchem-1667 12 19 , , PUNCT eurjchem-1667 12 20 have have AUX eurjchem-1667 12 21 used use VERB eurjchem-1667 12 22 many many ADJ eurjchem-1667 12 23 different different ADJ eurjchem-1667 12 24 medicines medicine NOUN eurjchem-1667 12 25 based base VERB eurjchem-1667 12 26 on on ADP eurjchem-1667 12 27 plants plant NOUN eurjchem-1667 12 28 , , PUNCT eurjchem-1667 12 29 animals animal NOUN eurjchem-1667 12 30 or or CCONJ eurjchem-1667 12 31 minerals mineral NOUN eurjchem-1667 12 32 to to PART eurjchem-1667 12 33 be be AUX eurjchem-1667 12 34 used use VERB eurjchem-1667 12 35 in in ADP eurjchem-1667 12 36 the the DET eurjchem-1667 12 37 treatment treatment NOUN eurjchem-1667 12 38 of of ADP eurjchem-1667 12 39 diseases disease NOUN eurjchem-1667 12 40 . . PUNCT eurjchem-1667 13 1 the the DET eurjchem-1667 13 2 changing change VERB eurjchem-1667 13 3 and and CCONJ eurjchem-1667 13 4 developing develop VERB eurjchem-1667 13 5 world world NOUN eurjchem-1667 13 6 has have AUX eurjchem-1667 13 7 brought bring VERB eurjchem-1667 13 8 evolution evolution NOUN eurjchem-1667 13 9 and and CCONJ eurjchem-1667 13 10 globalization globalization NOUN eurjchem-1667 13 11 in in ADP eurjchem-1667 13 12 the the DET eurjchem-1667 13 13 pharmaceutical pharmaceutical NOUN eurjchem-1667 13 14 sector sector NOUN eurjchem-1667 13 15 . . PUNCT eurjchem-1667 14 1 however however ADV eurjchem-1667 14 2 , , PUNCT eurjchem-1667 14 3 the the DET eurjchem-1667 14 4 only only ADJ eurjchem-1667 14 5 thing thing NOUN eurjchem-1667 14 6 did do AUX eurjchem-1667 14 7 not not PART eurjchem-1667 14 8 change change VERB eurjchem-1667 14 9 is be AUX eurjchem-1667 14 10 the the DET eurjchem-1667 14 11 impor‐ impor‐ NOUN eurjchem-1667 14 12 tance tance NOUN eurjchem-1667 14 13 of of ADP eurjchem-1667 14 14 the the DET eurjchem-1667 14 15 drug drug NOUN eurjchem-1667 14 16 quality quality NOUN eurjchem-1667 14 17 . . PUNCT eurjchem-1667 15 1 the the DET eurjchem-1667 15 2 pharmaceutical pharmaceutical NOUN eurjchem-1667 15 3 industry industry NOUN eurjchem-1667 15 4 is be AUX eurjchem-1667 15 5 a a DET eurjchem-1667 15 6 vital vital ADJ eurjchem-1667 15 7 industry industry NOUN eurjchem-1667 15 8 where where SCONJ eurjchem-1667 15 9 product product NOUN eurjchem-1667 15 10 quality quality NOUN eurjchem-1667 15 11 is be AUX eurjchem-1667 15 12 vital vital ADJ eurjchem-1667 15 13 and and CCONJ eurjchem-1667 15 14 the the DET eurjchem-1667 15 15 ability ability NOUN eurjchem-1667 15 16 to to PART eurjchem-1667 15 17 produce produce VERB eurjchem-1667 15 18 products product NOUN eurjchem-1667 15 19 constantly constantly ADV eurjchem-1667 15 20 at at ADP eurjchem-1667 15 21 the the DET eurjchem-1667 15 22 desired desire VERB eurjchem-1667 15 23 quality quality NOUN eurjchem-1667 15 24 is be AUX eurjchem-1667 15 25 indispensable indispensable ADJ eurjchem-1667 15 26 [ [ X eurjchem-1667 15 27 1 1 NUM eurjchem-1667 15 28 ] ] PUNCT eurjchem-1667 15 29 . . PUNCT eurjchem-1667 16 1 the the DET eurjchem-1667 16 2 increasing increase VERB eurjchem-1667 16 3 world world NOUN eurjchem-1667 16 4 population population NOUN eurjchem-1667 16 5 causes cause VERB eurjchem-1667 16 6 changes change NOUN eurjchem-1667 16 7 on on ADP eurjchem-1667 16 8 the the DET eurjchem-1667 16 9 welfare welfare NOUN eurjchem-1667 16 10 level level NOUN eurjchem-1667 16 11 of of ADP eurjchem-1667 16 12 the the DET eurjchem-1667 16 13 societies society NOUN eurjchem-1667 16 14 , , PUNCT eurjchem-1667 16 15 demographics demographic NOUN eurjchem-1667 16 16 , , PUNCT eurjchem-1667 16 17 and and CCONJ eurjchem-1667 16 18 living live VERB eurjchem-1667 16 19 condi‐ condi‐ PROPN eurjchem-1667 16 20 tions tion NOUN eurjchem-1667 16 21 , , PUNCT eurjchem-1667 16 22 consequently consequently ADV eurjchem-1667 16 23 the the DET eurjchem-1667 16 24 ecological ecological ADJ eurjchem-1667 16 25 equilibrium equilibrium NOUN eurjchem-1667 16 26 is be AUX eurjchem-1667 16 27 affected affect VERB eurjchem-1667 16 28 . . PUNCT eurjchem-1667 17 1 for for ADP eurjchem-1667 17 2 this this DET eurjchem-1667 17 3 reason reason NOUN eurjchem-1667 17 4 , , PUNCT eurjchem-1667 17 5 health health NOUN eurjchem-1667 17 6 problems problem NOUN eurjchem-1667 17 7 of of ADP eurjchem-1667 17 8 people people NOUN eurjchem-1667 17 9 are be AUX eurjchem-1667 17 10 also also ADV eurjchem-1667 17 11 increasing increase VERB eurjchem-1667 17 12 . . PUNCT eurjchem-1667 18 1 in in ADP eurjchem-1667 18 2 this this DET eurjchem-1667 18 3 context context NOUN eurjchem-1667 18 4 , , PUNCT eurjchem-1667 18 5 the the DET eurjchem-1667 18 6 quality quality NOUN eurjchem-1667 18 7 of of ADP eurjchem-1667 18 8 human human ADJ eurjchem-1667 18 9 life life NOUN eurjchem-1667 18 10 is be AUX eurjchem-1667 18 11 directly directly ADV eurjchem-1667 18 12 parallel parallel ADJ eurjchem-1667 18 13 to to ADP eurjchem-1667 18 14 the the DET eurjchem-1667 18 15 ability ability NOUN eurjchem-1667 18 16 to to PART eurjchem-1667 18 17 produce produce VERB eurjchem-1667 18 18 the the DET eurjchem-1667 18 19 medicine medicine NOUN eurjchem-1667 18 20 in in ADP eurjchem-1667 18 21 desired desire VERB eurjchem-1667 18 22 quality quality NOUN eurjchem-1667 18 23 . . PUNCT eurjchem-1667 19 1 thus thus ADV eurjchem-1667 19 2 , , PUNCT eurjchem-1667 19 3 the the DET eurjchem-1667 19 4 global global ADJ eurjchem-1667 19 5 pharmaceutical pharmaceutical ADJ eurjchem-1667 19 6 sector sector NOUN eurjchem-1667 19 7 is be AUX eurjchem-1667 19 8 constantly constantly ADV eurjchem-1667 19 9 improving improve VERB eurjchem-1667 19 10 and and CCONJ eurjchem-1667 19 11 investments investment NOUN eurjchem-1667 19 12 in in ADP eurjchem-1667 19 13 research research NOUN eurjchem-1667 19 14 and and CCONJ eurjchem-1667 19 15 development development NOUN eurjchem-1667 19 16 ( ( PUNCT eurjchem-1667 19 17 r&d r&d NOUN eurjchem-1667 19 18 ) ) PUNCT eurjchem-1667 19 19 and and CCONJ eurjchem-1667 19 20 innova‐ innova‐ NUM eurjchem-1667 19 21 tion tion NOUN eurjchem-1667 19 22 are be AUX eurjchem-1667 19 23 increasing increase VERB eurjchem-1667 19 24 . . PUNCT eurjchem-1667 20 1 the the DET eurjchem-1667 20 2 pharmaceutical pharmaceutical NOUN eurjchem-1667 20 3 industry industry NOUN eurjchem-1667 20 4 is be AUX eurjchem-1667 20 5 a a DET eurjchem-1667 20 6 lengthy lengthy ADJ eurjchem-1667 20 7 and and CCONJ eurjchem-1667 20 8 costly costly ADJ eurjchem-1667 20 9 process process NOUN eurjchem-1667 20 10 involving involve VERB eurjchem-1667 20 11 clinical clinical ADJ eurjchem-1667 20 12 research research NOUN eurjchem-1667 20 13 where where SCONJ eurjchem-1667 20 14 basic basic ADJ eurjchem-1667 20 15 research research NOUN eurjchem-1667 20 16 and and CCONJ eurjchem-1667 20 17 subsequent subsequent ADJ eurjchem-1667 20 18 clinical clinical ADJ eurjchem-1667 20 19 tests test NOUN eurjchem-1667 20 20 are be AUX eurjchem-1667 20 21 carried carry VERB eurjchem-1667 20 22 out out ADP eurjchem-1667 20 23 , , PUNCT eurjchem-1667 20 24 inclu‐ inclu‐ PROPN eurjchem-1667 20 25 ding de VERB eurjchem-1667 20 26 the the DET eurjchem-1667 20 27 identification identification NOUN eurjchem-1667 20 28 of of ADP eurjchem-1667 20 29 effective effective ADJ eurjchem-1667 20 30 molecules molecule NOUN eurjchem-1667 20 31 , , PUNCT eurjchem-1667 20 32 the the DET eurjchem-1667 20 33 discovery discovery NOUN eurjchem-1667 20 34 of of ADP eurjchem-1667 20 35 new new ADJ eurjchem-1667 20 36 areas area NOUN eurjchem-1667 20 37 of of ADP eurjchem-1667 20 38 use use NOUN eurjchem-1667 20 39 for for ADP eurjchem-1667 20 40 existing exist VERB eurjchem-1667 20 41 molecules molecule NOUN eurjchem-1667 20 42 , , PUNCT eurjchem-1667 20 43 and and CCONJ eurjchem-1667 20 44 the the DET eurjchem-1667 20 45 reassessment reassessment NOUN eurjchem-1667 20 46 of of ADP eurjchem-1667 20 47 a a DET eurjchem-1667 20 48 side side ADJ eurjchem-1667 20 49 effect effect NOUN eurjchem-1667 20 50 for for ADP eurjchem-1667 20 51 the the DET eurjchem-1667 20 52 drug drug NOUN eurjchem-1667 20 53 under under ADP eurjchem-1667 20 54 investigation investigation NOUN eurjchem-1667 20 55 [ [ X eurjchem-1667 20 56 2 2 NUM eurjchem-1667 20 57 ] ] PUNCT eurjchem-1667 20 58 . . PUNCT eurjchem-1667 21 1 today today NOUN eurjchem-1667 21 2 , , PUNCT eurjchem-1667 21 3 the the DET eurjchem-1667 21 4 development development NOUN eurjchem-1667 21 5 of of ADP eurjchem-1667 21 6 new new ADJ eurjchem-1667 21 7 technologies technology NOUN eurjchem-1667 21 8 to to PART eurjchem-1667 21 9 support support VERB eurjchem-1667 21 10 r&d r&d NOUN eurjchem-1667 21 11 and and CCONJ eurjchem-1667 21 12 production production NOUN eurjchem-1667 21 13 processes process NOUN eurjchem-1667 21 14 has have AUX eurjchem-1667 21 15 brought bring VERB eurjchem-1667 21 16 along along ADP eurjchem-1667 21 17 the the DET eurjchem-1667 21 18 development development NOUN eurjchem-1667 21 19 of of ADP eurjchem-1667 21 20 quality quality NOUN eurjchem-1667 21 21 medicines medicine NOUN eurjchem-1667 21 22 and and CCONJ eurjchem-1667 21 23 new new ADJ eurjchem-1667 21 24 approaches approach NOUN eurjchem-1667 21 25 in in ADP eurjchem-1667 21 26 therapy therapy NOUN eurjchem-1667 21 27 . . PUNCT eurjchem-1667 22 1 in in ADP eurjchem-1667 22 2 parti‐ parti‐ PROPN eurjchem-1667 22 3 cular cular NOUN eurjchem-1667 22 4 , , PUNCT eurjchem-1667 22 5 the the DET eurjchem-1667 22 6 computer‐assisted computer‐assiste VERB eurjchem-1667 22 7 experimental experimental ADJ eurjchem-1667 22 8 design design NOUN eurjchem-1667 22 9 is be AUX eurjchem-1667 22 10 expected expect VERB eurjchem-1667 22 11 to to PART eurjchem-1667 22 12 reduce reduce VERB eurjchem-1667 22 13 costs cost NOUN eurjchem-1667 22 14 and and CCONJ eurjchem-1667 22 15 increase increase VERB eurjchem-1667 22 16 quality quality NOUN eurjchem-1667 22 17 in in ADP eurjchem-1667 22 18 clinical clinical ADJ eurjchem-1667 22 19 research research NOUN eurjchem-1667 22 20 and and CCONJ eurjchem-1667 22 21 manufacturing manufacturing NOUN eurjchem-1667 22 22 processes process NOUN eurjchem-1667 22 23 [ [ X eurjchem-1667 22 24 2 2 NUM eurjchem-1667 22 25 ] ] PUNCT eurjchem-1667 22 26 . . PUNCT eurjchem-1667 23 1 the the DET eurjchem-1667 23 2 american american ADJ eurjchem-1667 23 3 food food PROPN eurjchem-1667 23 4 and and CCONJ eurjchem-1667 23 5 drug drug PROPN eurjchem-1667 23 6 administration administration PROPN eurjchem-1667 23 7 ( ( PUNCT eurjchem-1667 23 8 fda fda PROPN eurjchem-1667 23 9 ) ) PUNCT eurjchem-1667 23 10 and and CCONJ eurjchem-1667 23 11 the the DET eurjchem-1667 23 12 european european PROPN eurjchem-1667 23 13 medicines medicines PROPN eurjchem-1667 23 14 agency agency NOUN eurjchem-1667 23 15 ( ( PUNCT eurjchem-1667 23 16 ema ema PROPN eurjchem-1667 23 17 ) ) PUNCT eurjchem-1667 23 18 make make VERB eurjchem-1667 23 19 the the DET eurjchem-1667 23 20 definition definition NOUN eurjchem-1667 23 21 of of ADP eurjchem-1667 23 22 “ " PUNCT eurjchem-1667 23 23 quality quality NOUN eurjchem-1667 23 24 by by ADP eurjchem-1667 23 25 design design NOUN eurjchem-1667 23 26 ” " PUNCT eurjchem-1667 23 27 as as ADP eurjchem-1667 23 28 a a DET eurjchem-1667 23 29 scientific scientific ADJ eurjchem-1667 23 30 , , PUNCT eurjchem-1667 23 31 systematic systematic ADJ eurjchem-1667 23 32 , , PUNCT eurjchem-1667 23 33 and and CCONJ eurjchem-1667 23 34 risk‐ risk‐ NOUN eurjchem-1667 23 35 oriented orient VERB eurjchem-1667 23 36 approach approach NOUN eurjchem-1667 23 37 to to ADP eurjchem-1667 23 38 the the DET eurjchem-1667 23 39 production production NOUN eurjchem-1667 23 40 of of ADP eurjchem-1667 23 41 pharmaceutical pharmaceutical ADJ eurjchem-1667 23 42 products product NOUN eurjchem-1667 23 43 from from ADP eurjchem-1667 23 44 the the DET eurjchem-1667 23 45 empirical empirical ADJ eurjchem-1667 23 46 traditional traditional ADJ eurjchem-1667 23 47 processes process NOUN eurjchem-1667 23 48 [ [ X eurjchem-1667 23 49 3 3 NUM eurjchem-1667 23 50 ] ] PUNCT eurjchem-1667 23 51 . . PUNCT eurjchem-1667 24 1 this this DET eurjchem-1667 24 2 approach approach NOUN eurjchem-1667 24 3 involves involve VERB eurjchem-1667 24 4 building build VERB eurjchem-1667 24 5 the the DET eurjchem-1667 24 6 product product NOUN eurjchem-1667 24 7 by by ADP eurjchem-1667 24 8 designing design VERB eurjchem-1667 24 9 the the DET eurjchem-1667 24 10 stages stage NOUN eurjchem-1667 24 11 of of ADP eurjchem-1667 24 12 quality quality NOUN eurjchem-1667 24 13 improvement improvement NOUN eurjchem-1667 24 14 , , PUNCT eurjchem-1667 24 15 starting start VERB eurjchem-1667 24 16 from from ADP eurjchem-1667 24 17 the the DET eurjchem-1667 24 18 development development NOUN eurjchem-1667 24 19 of of ADP eurjchem-1667 24 20 the the DET eurjchem-1667 24 21 pharmaceutical pharmaceutical NOUN eurjchem-1667 24 22 product product NOUN eurjchem-1667 24 23 . . PUNCT eurjchem-1667 25 1 in in ADP eurjchem-1667 25 2 addition addition NOUN eurjchem-1667 25 3 , , PUNCT eurjchem-1667 25 4 risks risk NOUN eurjchem-1667 25 5 in in ADP eurjchem-1667 25 6 the the DET eurjchem-1667 25 7 production production NOUN eurjchem-1667 25 8 phase phase NOUN eurjchem-1667 25 9 are be AUX eurjchem-1667 25 10 controlled control VERB eurjchem-1667 25 11 by by ADP eurjchem-1667 25 12 quality quality NOUN eurjchem-1667 25 13 risk risk NOUN eurjchem-1667 25 14 management management NOUN eurjchem-1667 25 15 . . PUNCT eurjchem-1667 26 1 guidelines guideline NOUN eurjchem-1667 26 2 such such ADJ eurjchem-1667 26 3 as as ADP eurjchem-1667 26 4 ich ich PROPN eurjchem-1667 26 5 q8 q8 PROPN eurjchem-1667 26 6 , , PUNCT eurjchem-1667 26 7 ich ich PROPN eurjchem-1667 26 8 q9 q9 PROPN eurjchem-1667 26 9 , , PUNCT eurjchem-1667 26 10 ich ich PROPN eurjchem-1667 26 11 q10 q10 PROPN eurjchem-1667 26 12 , , PUNCT eurjchem-1667 26 13 ich ich NOUN eurjchem-1667 26 14 q11 q11 NOUN eurjchem-1667 26 15 and and CCONJ eurjchem-1667 26 16 ich ich PROPN eurjchem-1667 26 17 q12 q12 NOUN eurjchem-1667 26 18 published publish VERB eurjchem-1667 26 19 by by ADP eurjchem-1667 26 20 the the DET eurjchem-1667 26 21 international international ADJ eurjchem-1667 26 22 harmonization harmonization NOUN eurjchem-1667 26 23 commis‐ commis‐ NOUN eurjchem-1667 26 24 sion sion NOUN eurjchem-1667 26 25 ( ( PUNCT eurjchem-1667 26 26 ich ich NOUN eurjchem-1667 26 27 ) ) PUNCT eurjchem-1667 26 28 detail detail VERB eurjchem-1667 26 29 the the DET eurjchem-1667 26 30 scientific scientific ADJ eurjchem-1667 26 31 and and CCONJ eurjchem-1667 26 32 innovative innovative ADJ eurjchem-1667 26 33 design design NOUN eurjchem-1667 26 34 and and CCONJ eurjchem-1667 26 35 quality quality NOUN eurjchem-1667 26 36 perception perception NOUN eurjchem-1667 26 37 required require VERB eurjchem-1667 26 38 to to ADP eurjchem-1667 26 39 ensuring ensure VERB eurjchem-1667 26 40 consistent consistent ADJ eurjchem-1667 26 41 product product NOUN eurjchem-1667 26 42 quality quality NOUN eurjchem-1667 27 1 [ [ X eurjchem-1667 27 2 3 3 NUM eurjchem-1667 27 3 ] ] PUNCT eurjchem-1667 27 4 . . PUNCT eurjchem-1667 28 1 calhan calhan PROPN eurjchem-1667 28 2 et et PROPN eurjchem-1667 28 3 al al PROPN eurjchem-1667 28 4 . . PUNCT eurjchem-1667 28 5 / / SYM eurjchem-1667 28 6 european european PROPN eurjchem-1667 28 7 journal journal PROPN eurjchem-1667 28 8 of of ADP eurjchem-1667 28 9 chemistry chemistry NOUN eurjchem-1667 28 10 8 8 NUM eurjchem-1667 28 11 ( ( PUNCT eurjchem-1667 28 12 4 4 NUM eurjchem-1667 28 13 ) ) PUNCT eurjchem-1667 28 14 ( ( PUNCT eurjchem-1667 28 15 2017 2017 NUM eurjchem-1667 28 16 ) ) PUNCT eurjchem-1667 28 17 430‐433 430‐433 PROPN eurjchem-1667 28 18 431 431 NUM eurjchem-1667 28 19 figure figure NOUN eurjchem-1667 28 20 1 1 NUM eurjchem-1667 28 21 . . PUNCT eurjchem-1667 28 22 flow flow NOUN eurjchem-1667 28 23 diagram diagram NOUN eurjchem-1667 28 24 for for ADP eurjchem-1667 28 25 quality quality NOUN eurjchem-1667 28 26 by by ADP eurjchem-1667 28 27 design design NOUN eurjchem-1667 28 28 . . PUNCT eurjchem-1667 29 1 when when SCONJ eurjchem-1667 29 2 the the DET eurjchem-1667 29 3 literature literature NOUN eurjchem-1667 29 4 is be AUX eurjchem-1667 29 5 examined examine VERB eurjchem-1667 29 6 , , PUNCT eurjchem-1667 29 7 while while SCONJ eurjchem-1667 29 8 there there PRON eurjchem-1667 29 9 are be VERB eurjchem-1667 29 10 a a DET eurjchem-1667 29 11 large large ADJ eurjchem-1667 29 12 number number NOUN eurjchem-1667 29 13 of of ADP eurjchem-1667 29 14 studies study NOUN eurjchem-1667 29 15 [ [ X eurjchem-1667 29 16 4‐12 4‐12 X eurjchem-1667 29 17 ] ] X eurjchem-1667 29 18 in in ADP eurjchem-1667 29 19 which which PRON eurjchem-1667 29 20 qbd qbd NOUN eurjchem-1667 29 21 and and CCONJ eurjchem-1667 29 22 process process VERB eurjchem-1667 29 23 analytical analytical ADJ eurjchem-1667 29 24 technology technology NOUN eurjchem-1667 29 25 ( ( PUNCT eurjchem-1667 29 26 pat pat NOUN eurjchem-1667 29 27 ) ) PUNCT eurjchem-1667 29 28 applications application NOUN eurjchem-1667 29 29 are be AUX eurjchem-1667 29 30 analyzed analyze VERB eurjchem-1667 29 31 , , PUNCT eurjchem-1667 29 32 it it PRON eurjchem-1667 29 33 is be AUX eurjchem-1667 29 34 obvious obvious ADJ eurjchem-1667 29 35 that that SCONJ eurjchem-1667 29 36 conducting conduct VERB eurjchem-1667 29 37 more more ADJ eurjchem-1667 29 38 research research NOUN eurjchem-1667 29 39 in in ADP eurjchem-1667 29 40 this this DET eurjchem-1667 29 41 area area NOUN eurjchem-1667 29 42 is be AUX eurjchem-1667 29 43 necessary necessary ADJ eurjchem-1667 29 44 as as SCONJ eurjchem-1667 29 45 the the DET eurjchem-1667 29 46 benefits benefit NOUN eurjchem-1667 29 47 of of ADP eurjchem-1667 29 48 the the DET eurjchem-1667 29 49 field field NOUN eurjchem-1667 29 50 are be AUX eurjchem-1667 29 51 taken take VERB eurjchem-1667 29 52 into into ADP eurjchem-1667 29 53 consideration consideration NOUN eurjchem-1667 29 54 . . PUNCT eurjchem-1667 30 1 the the DET eurjchem-1667 30 2 approach approach NOUN eurjchem-1667 30 3 of of ADP eurjchem-1667 30 4 designing design VERB eurjchem-1667 30 5 pharmaceutical pharmaceutical ADJ eurjchem-1667 30 6 products product NOUN eurjchem-1667 30 7 with with ADP eurjchem-1667 30 8 quality quality NOUN eurjchem-1667 30 9 rather rather ADV eurjchem-1667 30 10 than than ADP eurjchem-1667 30 11 testing test VERB eurjchem-1667 30 12 the the DET eurjchem-1667 30 13 final final ADJ eurjchem-1667 30 14 product product NOUN eurjchem-1667 30 15 during during ADP eurjchem-1667 30 16 the the DET eurjchem-1667 30 17 pharmaceutical pharmaceutical ADJ eurjchem-1667 30 18 product product NOUN eurjchem-1667 30 19 development development NOUN eurjchem-1667 30 20 process process NOUN eurjchem-1667 30 21 , , PUNCT eurjchem-1667 30 22 which which PRON eurjchem-1667 30 23 is be AUX eurjchem-1667 30 24 difficult difficult ADJ eurjchem-1667 30 25 and and CCONJ eurjchem-1667 30 26 costly costly ADJ eurjchem-1667 30 27 , , PUNCT eurjchem-1667 30 28 is be AUX eurjchem-1667 30 29 a a DET eurjchem-1667 30 30 topic topic NOUN eurjchem-1667 30 31 that that PRON eurjchem-1667 30 32 attracts attract VERB eurjchem-1667 30 33 growing grow VERB eurjchem-1667 30 34 interest interest NOUN eurjchem-1667 30 35 . . PUNCT eurjchem-1667 31 1 in in ADP eurjchem-1667 31 2 this this DET eurjchem-1667 31 3 sense sense NOUN eurjchem-1667 31 4 , , PUNCT eurjchem-1667 31 5 the the DET eurjchem-1667 31 6 applications application NOUN eurjchem-1667 31 7 of of ADP eurjchem-1667 31 8 the the DET eurjchem-1667 31 9 qbd qbd PROPN eurjchem-1667 31 10 and and CCONJ eurjchem-1667 31 11 pat pat PROPN eurjchem-1667 31 12 in in ADP eurjchem-1667 31 13 the the DET eurjchem-1667 31 14 pharmaceutical pharmaceutical NOUN eurjchem-1667 31 15 industry industry NOUN eurjchem-1667 31 16 have have AUX eurjchem-1667 31 17 been be AUX eurjchem-1667 31 18 increasing increase VERB eurjchem-1667 31 19 . . PUNCT eurjchem-1667 32 1 in in ADP eurjchem-1667 32 2 this this DET eurjchem-1667 32 3 context context NOUN eurjchem-1667 32 4 , , PUNCT eurjchem-1667 32 5 this this DET eurjchem-1667 32 6 study study NOUN eurjchem-1667 32 7 will will AUX eurjchem-1667 32 8 present present VERB eurjchem-1667 32 9 the the DET eurjchem-1667 32 10 advantages advantage NOUN eurjchem-1667 32 11 and and CCONJ eurjchem-1667 32 12 disadvantages disadvantage NOUN eurjchem-1667 32 13 provided provide VERB eurjchem-1667 32 14 by by ADP eurjchem-1667 32 15 pat pat PROPN eurjchem-1667 32 16 , , PUNCT eurjchem-1667 32 17 pat pat PROPN eurjchem-1667 32 18 steps step NOUN eurjchem-1667 32 19 , , PUNCT eurjchem-1667 32 20 pat pat NOUN eurjchem-1667 32 21 tools tool NOUN eurjchem-1667 32 22 and and CCONJ eurjchem-1667 32 23 pat pat NOUN eurjchem-1667 32 24 , , PUNCT eurjchem-1667 32 25 by by ADP eurjchem-1667 32 26 putting put VERB eurjchem-1667 32 27 emphasis emphasis NOUN eurjchem-1667 32 28 on on ADP eurjchem-1667 32 29 the the DET eurjchem-1667 32 30 necessity necessity NOUN eurjchem-1667 32 31 of of ADP eurjchem-1667 32 32 the the DET eurjchem-1667 32 33 qbd qbd PROPN eurjchem-1667 32 34 approach approach NOUN eurjchem-1667 32 35 . . PUNCT eurjchem-1667 33 1 subsequently subsequently ADV eurjchem-1667 33 2 , , PUNCT eurjchem-1667 33 3 the the DET eurjchem-1667 33 4 examples example NOUN eurjchem-1667 33 5 of of ADP eurjchem-1667 33 6 the the DET eurjchem-1667 33 7 applications application NOUN eurjchem-1667 33 8 of of ADP eurjchem-1667 33 9 pat pat PROPN eurjchem-1667 33 10 in in ADP eurjchem-1667 33 11 the the DET eurjchem-1667 33 12 pharmaceutical pharmaceutical NOUN eurjchem-1667 33 13 industry industry NOUN eurjchem-1667 33 14 will will AUX eurjchem-1667 33 15 be be AUX eurjchem-1667 33 16 summarized summarize VERB eurjchem-1667 33 17 . . PUNCT eurjchem-1667 34 1 1.1 1.1 NUM eurjchem-1667 34 2 . . PUNCT eurjchem-1667 35 1 quality quality NOUN eurjchem-1667 35 2 by by ADP eurjchem-1667 35 3 design design NOUN eurjchem-1667 35 4 steps step NOUN eurjchem-1667 35 5 as as SCONJ eurjchem-1667 35 6 shown show VERB eurjchem-1667 35 7 in in ADP eurjchem-1667 35 8 figure figure NOUN eurjchem-1667 35 9 1 1 NUM eurjchem-1667 35 10 , , PUNCT eurjchem-1667 35 11 the the DET eurjchem-1667 35 12 first first ADJ eurjchem-1667 35 13 step step NOUN eurjchem-1667 35 14 in in ADP eurjchem-1667 35 15 design design NOUN eurjchem-1667 35 16 and and CCONJ eurjchem-1667 35 17 quality quality NOUN eurjchem-1667 35 18 approach approach NOUN eurjchem-1667 35 19 is be AUX eurjchem-1667 35 20 to to PART eurjchem-1667 35 21 determine determine VERB eurjchem-1667 35 22 the the DET eurjchem-1667 35 23 intended intend VERB eurjchem-1667 35 24 use use NOUN eurjchem-1667 35 25 of of ADP eurjchem-1667 35 26 the the DET eurjchem-1667 35 27 product product NOUN eurjchem-1667 35 28 and and CCONJ eurjchem-1667 35 29 the the DET eurjchem-1667 35 30 appropriate appropriate ADJ eurjchem-1667 35 31 quality quality NOUN eurjchem-1667 35 32 addressing address VERB eurjchem-1667 35 33 this this DET eurjchem-1667 35 34 purpose purpose NOUN eurjchem-1667 35 35 . . PUNCT eurjchem-1667 36 1 in in ADP eurjchem-1667 36 2 the the DET eurjchem-1667 36 3 second second ADJ eurjchem-1667 36 4 step step NOUN eurjchem-1667 36 5 , , PUNCT eurjchem-1667 36 6 the the DET eurjchem-1667 36 7 scientific scientific ADJ eurjchem-1667 36 8 data datum NOUN eurjchem-1667 36 9 and and CCONJ eurjchem-1667 36 10 information information NOUN eurjchem-1667 36 11 necessary necessary ADJ eurjchem-1667 36 12 to to PART eurjchem-1667 36 13 define define VERB eurjchem-1667 36 14 the the DET eurjchem-1667 36 15 critical critical ADJ eurjchem-1667 36 16 quality quality NOUN eurjchem-1667 36 17 characteristics characteristic NOUN eurjchem-1667 36 18 are be AUX eurjchem-1667 36 19 evaluated evaluate VERB eurjchem-1667 36 20 . . PUNCT eurjchem-1667 37 1 in in ADP eurjchem-1667 37 2 the the DET eurjchem-1667 37 3 next next ADJ eurjchem-1667 37 4 stage stage NOUN eurjchem-1667 37 5 , , PUNCT eurjchem-1667 37 6 process process NOUN eurjchem-1667 37 7 development development NOUN eurjchem-1667 37 8 is be AUX eurjchem-1667 37 9 evaluated evaluate VERB eurjchem-1667 37 10 with with ADP eurjchem-1667 37 11 concepts concept NOUN eurjchem-1667 37 12 such such ADJ eurjchem-1667 37 13 as as ADP eurjchem-1667 37 14 experimental experimental ADJ eurjchem-1667 37 15 design design NOUN eurjchem-1667 37 16 , , PUNCT eurjchem-1667 37 17 process process NOUN eurjchem-1667 37 18 analytical analytical ADJ eurjchem-1667 37 19 technology technology NOUN eurjchem-1667 37 20 and and CCONJ eurjchem-1667 37 21 risk risk NOUN eurjchem-1667 37 22 control control NOUN eurjchem-1667 37 23 . . PUNCT eurjchem-1667 38 1 in in ADP eurjchem-1667 38 2 addition addition NOUN eurjchem-1667 38 3 , , PUNCT eurjchem-1667 38 4 a a DET eurjchem-1667 38 5 design design NOUN eurjchem-1667 38 6 area area NOUN eurjchem-1667 38 7 ensuring ensure VERB eurjchem-1667 38 8 quality quality NOUN eurjchem-1667 38 9 in in ADP eurjchem-1667 38 10 this this DET eurjchem-1667 38 11 step step NOUN eurjchem-1667 38 12 is be AUX eurjchem-1667 38 13 established establish VERB eurjchem-1667 38 14 . . PUNCT eurjchem-1667 39 1 the the DET eurjchem-1667 39 2 following follow VERB eurjchem-1667 39 3 step step NOUN eurjchem-1667 39 4 is be AUX eurjchem-1667 39 5 the the DET eurjchem-1667 39 6 identification identification NOUN eurjchem-1667 39 7 and and CCONJ eurjchem-1667 39 8 design design NOUN eurjchem-1667 39 9 of of ADP eurjchem-1667 39 10 the the DET eurjchem-1667 39 11 control control NOUN eurjchem-1667 39 12 strategy strategy NOUN eurjchem-1667 39 13 . . PUNCT eurjchem-1667 40 1 in in ADP eurjchem-1667 40 2 the the DET eurjchem-1667 40 3 last last ADJ eurjchem-1667 40 4 step step NOUN eurjchem-1667 40 5 , , PUNCT eurjchem-1667 40 6 continuous continuous ADJ eurjchem-1667 40 7 improvement improvement NOUN eurjchem-1667 40 8 and and CCONJ eurjchem-1667 40 9 life life NOUN eurjchem-1667 40 10 cycle cycle NOUN eurjchem-1667 40 11 are be AUX eurjchem-1667 40 12 provided provide VERB eurjchem-1667 40 13 by by ADP eurjchem-1667 40 14 the the DET eurjchem-1667 40 15 combination combination NOUN eurjchem-1667 40 16 of of ADP eurjchem-1667 40 17 quality quality NOUN eurjchem-1667 40 18 risk risk NOUN eurjchem-1667 40 19 management management NOUN eurjchem-1667 40 20 and and CCONJ eurjchem-1667 40 21 product product NOUN eurjchem-1667 40 22 process process NOUN eurjchem-1667 40 23 knowledge knowledge NOUN eurjchem-1667 40 24 . . PUNCT eurjchem-1667 41 1 in in ADP eurjchem-1667 41 2 the the DET eurjchem-1667 41 3 traditional traditional ADJ eurjchem-1667 41 4 pharmaceutical pharmaceutical ADJ eurjchem-1667 41 5 development development NOUN eurjchem-1667 41 6 process process NOUN eurjchem-1667 41 7 , , PUNCT eurjchem-1667 41 8 univariate univariate ADJ eurjchem-1667 41 9 experiments experiment NOUN eurjchem-1667 41 10 are be AUX eurjchem-1667 41 11 reproducibility reproducibility NOUN eurjchem-1667 41 12 centered center VERB eurjchem-1667 41 13 , , PUNCT eurjchem-1667 41 14 while while SCONJ eurjchem-1667 41 15 systematic systematic ADJ eurjchem-1667 41 16 experiments experiment NOUN eurjchem-1667 41 17 that that PRON eurjchem-1667 41 18 are be AUX eurjchem-1667 41 19 highly highly ADV eurjchem-1667 41 20 variable variable ADJ eurjchem-1667 41 21 in in ADP eurjchem-1667 41 22 design design NOUN eurjchem-1667 41 23 and and CCONJ eurjchem-1667 41 24 quality quality NOUN eurjchem-1667 41 25 are be AUX eurjchem-1667 41 26 conducted conduct VERB eurjchem-1667 41 27 in in ADP eurjchem-1667 41 28 a a DET eurjchem-1667 41 29 design design NOUN eurjchem-1667 41 30 area area NOUN eurjchem-1667 41 31 and and CCONJ eurjchem-1667 41 32 centered center VERB eurjchem-1667 41 33 on on ADP eurjchem-1667 41 34 the the DET eurjchem-1667 41 35 control control NOUN eurjchem-1667 41 36 strategy strategy NOUN eurjchem-1667 41 37 . . PUNCT eurjchem-1667 42 1 however however ADV eurjchem-1667 42 2 , , PUNCT eurjchem-1667 42 3 in in ADP eurjchem-1667 42 4 the the DET eurjchem-1667 42 5 traditional traditional ADJ eurjchem-1667 42 6 approach approach NOUN eurjchem-1667 42 7 , , PUNCT eurjchem-1667 42 8 the the DET eurjchem-1667 42 9 control control NOUN eurjchem-1667 42 10 strategy strategy NOUN eurjchem-1667 42 11 is be AUX eurjchem-1667 42 12 predominantly predominantly ADV eurjchem-1667 42 13 composed compose VERB eurjchem-1667 42 14 of of ADP eurjchem-1667 42 15 intermediate intermediate ADJ eurjchem-1667 42 16 and and CCONJ eurjchem-1667 42 17 finished finish VERB eurjchem-1667 42 18 product product NOUN eurjchem-1667 42 19 tests test NOUN eurjchem-1667 42 20 , , PUNCT eurjchem-1667 42 21 whereas whereas SCONJ eurjchem-1667 42 22 in in ADP eurjchem-1667 42 23 the the DET eurjchem-1667 42 24 design design NOUN eurjchem-1667 42 25 approach approach NOUN eurjchem-1667 42 26 the the DET eurjchem-1667 42 27 controls control NOUN eurjchem-1667 42 28 are be AUX eurjchem-1667 42 29 made make VERB eurjchem-1667 42 30 in in ADP eurjchem-1667 42 31 the the DET eurjchem-1667 42 32 production production NOUN eurjchem-1667 42 33 phase phase NOUN eurjchem-1667 42 34 and and CCONJ eurjchem-1667 42 35 real‐time real‐time NOUN eurjchem-1667 42 36 release release NOUN eurjchem-1667 42 37 is be AUX eurjchem-1667 42 38 the the DET eurjchem-1667 42 39 case case NOUN eurjchem-1667 42 40 . . PUNCT eurjchem-1667 43 1 additionally additionally ADV eurjchem-1667 43 2 , , PUNCT eurjchem-1667 43 3 process process NOUN eurjchem-1667 43 4 control control NOUN eurjchem-1667 43 5 is be AUX eurjchem-1667 43 6 done do VERB eurjchem-1667 43 7 with with ADP eurjchem-1667 43 8 an an DET eurjchem-1667 43 9 off‐line off‐line ADJ eurjchem-1667 43 10 analysis analysis NOUN eurjchem-1667 43 11 in in ADP eurjchem-1667 43 12 the the DET eurjchem-1667 43 13 traditional traditional ADJ eurjchem-1667 43 14 approach approach NOUN eurjchem-1667 43 15 while while SCONJ eurjchem-1667 43 16 pat pat PROPN eurjchem-1667 43 17 is be AUX eurjchem-1667 43 18 used use VERB eurjchem-1667 43 19 in in ADP eurjchem-1667 43 20 design design NOUN eurjchem-1667 43 21 and and CCONJ eurjchem-1667 43 22 quality quality NOUN eurjchem-1667 43 23 understanding understanding NOUN eurjchem-1667 43 24 [ [ X eurjchem-1667 43 25 1 1 NUM eurjchem-1667 43 26 ] ] PUNCT eurjchem-1667 43 27 . . PUNCT eurjchem-1667 44 1 1.2 1.2 NUM eurjchem-1667 44 2 . . PUNCT eurjchem-1667 45 1 proses proses PROPN eurjchem-1667 45 2 analytical analytical ADJ eurjchem-1667 45 3 technology technology PROPN eurjchem-1667 45 4 the the DET eurjchem-1667 45 5 fda fda PROPN eurjchem-1667 45 6 ( ( PUNCT eurjchem-1667 45 7 2004 2004 NUM eurjchem-1667 45 8 ) ) PUNCT eurjchem-1667 45 9 defines define NOUN eurjchem-1667 45 10 process process NOUN eurjchem-1667 45 11 analytical analytical ADJ eurjchem-1667 45 12 technology technology NOUN eurjchem-1667 45 13 as as ADP eurjchem-1667 45 14 designing designing NOUN eurjchem-1667 45 15 , , PUNCT eurjchem-1667 45 16 analyzing analyze VERB eurjchem-1667 45 17 and and CCONJ eurjchem-1667 45 18 controlling control VERB eurjchem-1667 45 19 the the DET eurjchem-1667 45 20 critical critical ADJ eurjchem-1667 45 21 quality quality NOUN eurjchem-1667 45 22 performance performance NOUN eurjchem-1667 45 23 characteristics characteristic NOUN eurjchem-1667 45 24 of of ADP eurjchem-1667 45 25 the the DET eurjchem-1667 45 26 materials material NOUN eurjchem-1667 45 27 and and CCONJ eurjchem-1667 45 28 processes process NOUN eurjchem-1667 45 29 in in ADP eurjchem-1667 45 30 the the DET eurjchem-1667 45 31 process process NOUN eurjchem-1667 45 32 with with ADP eurjchem-1667 45 33 real‐time real‐time NOUN eurjchem-1667 45 34 measurements measurement NOUN eurjchem-1667 45 35 to to PART eurjchem-1667 45 36 ensure ensure VERB eurjchem-1667 45 37 the the DET eurjchem-1667 45 38 quality quality NOUN eurjchem-1667 45 39 of of ADP eurjchem-1667 45 40 the the DET eurjchem-1667 45 41 final final ADJ eurjchem-1667 45 42 product product NOUN eurjchem-1667 45 43 . . PUNCT eurjchem-1667 46 1 the the DET eurjchem-1667 46 2 analytical analytical ADJ eurjchem-1667 46 3 term term NOUN eurjchem-1667 46 4 in in ADP eurjchem-1667 46 5 this this DET eurjchem-1667 46 6 approach approach NOUN eurjchem-1667 46 7 is be AUX eurjchem-1667 46 8 generally generally ADV eurjchem-1667 46 9 referring refer VERB eurjchem-1667 46 10 to to ADP eurjchem-1667 46 11 an an DET eurjchem-1667 46 12 integrated integrate VERB eurjchem-1667 46 13 use use NOUN eurjchem-1667 46 14 with with ADP eurjchem-1667 46 15 chemical chemical NOUN eurjchem-1667 46 16 , , PUNCT eurjchem-1667 46 17 physical physical ADJ eurjchem-1667 46 18 , , PUNCT eurjchem-1667 46 19 microbiological microbiological ADJ eurjchem-1667 46 20 , , PUNCT eurjchem-1667 46 21 mathematical mathematical ADJ eurjchem-1667 46 22 and and CCONJ eurjchem-1667 46 23 risk risk NOUN eurjchem-1667 46 24 analysis analysis NOUN eurjchem-1667 46 25 . . PUNCT eurjchem-1667 47 1 pat pat PROPN eurjchem-1667 47 2 ’s ’s PART eurjchem-1667 47 3 aim aim NOUN eurjchem-1667 47 4 is be AUX eurjchem-1667 47 5 to to PART eurjchem-1667 47 6 understand understand VERB eurjchem-1667 47 7 and and CCONJ eurjchem-1667 47 8 control control VERB eurjchem-1667 47 9 the the DET eurjchem-1667 47 10 production production NOUN eurjchem-1667 47 11 process process NOUN eurjchem-1667 47 12 that that PRON eurjchem-1667 47 13 is be AUX eurjchem-1667 47 14 consistent consistent ADJ eurjchem-1667 47 15 with with ADP eurjchem-1667 47 16 our our PRON eurjchem-1667 47 17 current current ADJ eurjchem-1667 47 18 drug drug NOUN eurjchem-1667 47 19 quality quality NOUN eurjchem-1667 47 20 system system NOUN eurjchem-1667 47 21 . . PUNCT eurjchem-1667 48 1 in in ADP eurjchem-1667 48 2 this this DET eurjchem-1667 48 3 respect respect NOUN eurjchem-1667 48 4 , , PUNCT eurjchem-1667 48 5 the the DET eurjchem-1667 48 6 quality quality NOUN eurjchem-1667 48 7 concept concept NOUN eurjchem-1667 48 8 for for ADP eurjchem-1667 48 9 the the DET eurjchem-1667 48 10 pharmaceutical pharmaceutical ADJ eurjchem-1667 48 11 industry industry NOUN eurjchem-1667 48 12 should should AUX eurjchem-1667 48 13 be be AUX eurjchem-1667 48 14 “ " PUNCT eurjchem-1667 48 15 the the DET eurjchem-1667 48 16 quality quality NOUN eurjchem-1667 48 17 should should AUX eurjchem-1667 48 18 be be AUX eurjchem-1667 48 19 designed design VERB eurjchem-1667 48 20 for for ADP eurjchem-1667 48 21 pharmaceutical pharmaceutical ADJ eurjchem-1667 48 22 products product NOUN eurjchem-1667 48 23 and and CCONJ eurjchem-1667 48 24 the the DET eurjchem-1667 48 25 products product NOUN eurjchem-1667 48 26 should should AUX eurjchem-1667 48 27 be be AUX eurjchem-1667 48 28 built build VERB eurjchem-1667 48 29 in in ADP eurjchem-1667 48 30 this this DET eurjchem-1667 48 31 direction direction NOUN eurjchem-1667 48 32 , , PUNCT eurjchem-1667 48 33 the the DET eurjchem-1667 48 34 quality quality NOUN eurjchem-1667 48 35 tests test NOUN eurjchem-1667 48 36 applied apply VERB eurjchem-1667 48 37 to to ADP eurjchem-1667 48 38 the the DET eurjchem-1667 48 39 final final ADJ eurjchem-1667 48 40 product product NOUN eurjchem-1667 48 41 do do AUX eurjchem-1667 48 42 not not PART eurjchem-1667 48 43 show show VERB eurjchem-1667 48 44 the the DET eurjchem-1667 48 45 actual actual ADJ eurjchem-1667 48 46 quality quality NOUN eurjchem-1667 48 47 ” " PUNCT eurjchem-1667 49 1 [ [ X eurjchem-1667 49 2 13 13 NUM eurjchem-1667 49 3 ] ] PUNCT eurjchem-1667 49 4 . . PUNCT eurjchem-1667 50 1 1.2.1 1.2.1 NUM eurjchem-1667 50 2 . . PUNCT eurjchem-1667 51 1 proses proses PROPN eurjchem-1667 51 2 analytical analytical ADJ eurjchem-1667 51 3 technology technology NOUN eurjchem-1667 51 4 steps step VERB eurjchem-1667 51 5 pat pat PROPN eurjchem-1667 51 6 consists consist VERB eurjchem-1667 51 7 of of ADP eurjchem-1667 51 8 three three NUM eurjchem-1667 51 9 main main ADJ eurjchem-1667 51 10 steps step NOUN eurjchem-1667 51 11 in in ADP eurjchem-1667 51 12 the the DET eurjchem-1667 51 13 form form NOUN eurjchem-1667 51 14 of of ADP eurjchem-1667 51 15 the the DET eurjchem-1667 51 16 interrelated interrelated ADJ eurjchem-1667 51 17 design design NOUN eurjchem-1667 51 18 , , PUNCT eurjchem-1667 51 19 analysis analysis NOUN eurjchem-1667 51 20 and and CCONJ eurjchem-1667 51 21 control control NOUN eurjchem-1667 51 22 ( ( PUNCT eurjchem-1667 51 23 figure figure NOUN eurjchem-1667 51 24 2 2 NUM eurjchem-1667 51 25 ) ) PUNCT eurjchem-1667 51 26 . . PUNCT eurjchem-1667 52 1 in in ADP eurjchem-1667 52 2 deter‐ deter‐ NOUN eurjchem-1667 52 3 mining mine VERB eurjchem-1667 52 4 the the DET eurjchem-1667 52 5 quality quality NOUN eurjchem-1667 52 6 of of ADP eurjchem-1667 52 7 the the DET eurjchem-1667 52 8 final final ADJ eurjchem-1667 52 9 product product NOUN eurjchem-1667 52 10 at at ADP eurjchem-1667 52 11 the the DET eurjchem-1667 52 12 design design NOUN eurjchem-1667 52 13 step step NOUN eurjchem-1667 52 14 , , PUNCT eurjchem-1667 52 15 it it PRON eurjchem-1667 52 16 is be AUX eurjchem-1667 52 17 necessary necessary ADJ eurjchem-1667 52 18 to to PART eurjchem-1667 52 19 determine determine VERB eurjchem-1667 52 20 the the DET eurjchem-1667 52 21 level level NOUN eurjchem-1667 52 22 of of ADP eurjchem-1667 52 23 effects effect NOUN eurjchem-1667 52 24 of of ADP eurjchem-1667 52 25 each each DET eurjchem-1667 52 26 process process NOUN eurjchem-1667 52 27 step step NOUN eurjchem-1667 52 28 and and CCONJ eurjchem-1667 52 29 starting starting NOUN eurjchem-1667 52 30 material material NOUN eurjchem-1667 52 31 . . PUNCT eurjchem-1667 53 1 in in ADP eurjchem-1667 53 2 the the DET eurjchem-1667 53 3 analysis analysis NOUN eurjchem-1667 53 4 step step NOUN eurjchem-1667 53 5 , , PUNCT eurjchem-1667 53 6 direct direct ADJ eurjchem-1667 53 7 or or CCONJ eurjchem-1667 53 8 indirect indirect ADJ eurjchem-1667 53 9 analytical analytical ADJ eurjchem-1667 53 10 tools tool NOUN eurjchem-1667 53 11 are be AUX eurjchem-1667 53 12 used use VERB eurjchem-1667 53 13 in in ADP eurjchem-1667 53 14 real real ADJ eurjchem-1667 53 15 time time NOUN eurjchem-1667 53 16 to to PART eurjchem-1667 53 17 determine determine VERB eurjchem-1667 53 18 the the DET eurjchem-1667 53 19 quality quality NOUN eurjchem-1667 53 20 features feature NOUN eurjchem-1667 53 21 of of ADP eurjchem-1667 53 22 the the DET eurjchem-1667 53 23 process process NOUN eurjchem-1667 53 24 materials material NOUN eurjchem-1667 53 25 and and CCONJ eurjchem-1667 53 26 raw raw ADJ eurjchem-1667 53 27 material material NOUN eurjchem-1667 53 28 . . PUNCT eurjchem-1667 54 1 finally finally ADV eurjchem-1667 54 2 , , PUNCT eurjchem-1667 54 3 in in ADP eurjchem-1667 54 4 the the DET eurjchem-1667 54 5 last last ADJ eurjchem-1667 54 6 step step NOUN eurjchem-1667 54 7 , , PUNCT eurjchem-1667 54 8 the the DET eurjchem-1667 54 9 harmony harmony NOUN eurjchem-1667 54 10 between between ADP eurjchem-1667 54 11 all all DET eurjchem-1667 54 12 the the DET eurjchem-1667 54 13 results result NOUN eurjchem-1667 54 14 obtained obtain VERB eurjchem-1667 54 15 through through ADP eurjchem-1667 54 16 a a DET eurjchem-1667 54 17 process process NOUN eurjchem-1667 54 18 control control NOUN eurjchem-1667 54 19 is be AUX eurjchem-1667 54 20 evaluated evaluate VERB eurjchem-1667 54 21 [ [ X eurjchem-1667 54 22 14 14 NUM eurjchem-1667 54 23 ] ] PUNCT eurjchem-1667 54 24 . . PUNCT eurjchem-1667 55 1 figure figure NOUN eurjchem-1667 55 2 2 2 NUM eurjchem-1667 55 3 . . PUNCT eurjchem-1667 55 4 process process NOUN eurjchem-1667 55 5 analytical analytical ADJ eurjchem-1667 55 6 technology technology NOUN eurjchem-1667 55 7 steps step NOUN eurjchem-1667 55 8 . . PUNCT eurjchem-1667 56 1 1.2.2 1.2.2 X eurjchem-1667 56 2 . . PUNCT eurjchem-1667 57 1 proses proses PROPN eurjchem-1667 57 2 analytical analytical ADJ eurjchem-1667 57 3 technology technology NOUN eurjchem-1667 57 4 tools tool VERB eurjchem-1667 57 5 pat pat NOUN eurjchem-1667 57 6 tools tool NOUN eurjchem-1667 57 7 include include VERB eurjchem-1667 57 8 highly highly ADV eurjchem-1667 57 9 variable variable ADJ eurjchem-1667 57 10 data datum NOUN eurjchem-1667 57 11 acquisition acquisition NOUN eurjchem-1667 57 12 , , PUNCT eurjchem-1667 57 13 process process NOUN eurjchem-1667 57 14 analyzers analyzer NOUN eurjchem-1667 57 15 , , PUNCT eurjchem-1667 57 16 process process NOUN eurjchem-1667 57 17 control control NOUN eurjchem-1667 57 18 tools tool NOUN eurjchem-1667 57 19 , , PUNCT eurjchem-1667 57 20 and and CCONJ eurjchem-1667 57 21 continuous continuous ADJ eurjchem-1667 57 22 improvement improvement NOUN eurjchem-1667 57 23 and and CCONJ eurjchem-1667 57 24 information information NOUN eurjchem-1667 57 25 management management NOUN eurjchem-1667 57 26 tools tool NOUN eurjchem-1667 57 27 for for ADP eurjchem-1667 57 28 data data NOUN eurjchem-1667 57 29 collection collection NOUN eurjchem-1667 57 30 and and CCONJ eurjchem-1667 57 31 analysis analysis NOUN eurjchem-1667 57 32 . . PUNCT eurjchem-1667 58 1 raman raman NOUN eurjchem-1667 58 2 spectroscopy spectroscopy NOUN eurjchem-1667 58 3 ( ( PUNCT eurjchem-1667 58 4 raman raman NOUN eurjchem-1667 58 5 ) ) PUNCT eurjchem-1667 58 6 , , PUNCT eurjchem-1667 58 7 near near ADP eurjchem-1667 58 8 infrared infrared ADJ eurjchem-1667 58 9 spectroscopy spectroscopy NOUN eurjchem-1667 58 10 ( ( PUNCT eurjchem-1667 58 11 nirs nirs PROPN eurjchem-1667 58 12 ) ) PUNCT eurjchem-1667 58 13 , , PUNCT eurjchem-1667 58 14 ultraviolet‐visible ultraviolet‐visible ADJ eurjchem-1667 58 15 region region NOUN eurjchem-1667 58 16 spectroscopy spectroscopy NOUN eurjchem-1667 58 17 ( ( PUNCT eurjchem-1667 58 18 uv‐vis uv‐vis PROPN eurjchem-1667 58 19 ) ) PUNCT eurjchem-1667 58 20 and and CCONJ eurjchem-1667 58 21 nuclear nuclear ADJ eurjchem-1667 58 22 magnetic magnetic ADJ eurjchem-1667 58 23 resonance resonance NOUN eurjchem-1667 58 24 spectroscopy spectroscopy NOUN eurjchem-1667 58 25 ( ( PUNCT eurjchem-1667 58 26 nmr nmr NOUN eurjchem-1667 58 27 ) ) PUNCT eurjchem-1667 58 28 are be AUX eurjchem-1667 58 29 frequently frequently ADV eurjchem-1667 58 30 used use VERB eurjchem-1667 58 31 in in ADP eurjchem-1667 58 32 pat pat NOUN eurjchem-1667 58 33 applications application NOUN eurjchem-1667 58 34 in in ADP eurjchem-1667 58 35 the the DET eurjchem-1667 58 36 pharmaceutical pharmaceutical ADJ eurjchem-1667 58 37 industry industry NOUN eurjchem-1667 58 38 . . PUNCT eurjchem-1667 59 1 particularly particularly ADV eurjchem-1667 59 2 nirs nirs PROPN eurjchem-1667 59 3 is be AUX eurjchem-1667 59 4 widely widely ADV eurjchem-1667 59 5 used use VERB eurjchem-1667 59 6 in in ADP eurjchem-1667 59 7 the the DET eurjchem-1667 59 8 determination determination NOUN eurjchem-1667 59 9 of of ADP eurjchem-1667 59 10 process process NOUN eurjchem-1667 59 11 parameters parameter NOUN eurjchem-1667 59 12 and and CCONJ eurjchem-1667 59 13 limit limit VERB eurjchem-1667 59 14 compliance compliance NOUN eurjchem-1667 59 15 , , PUNCT eurjchem-1667 59 16 optimum optimum ADJ eurjchem-1667 59 17 values value NOUN eurjchem-1667 59 18 , , PUNCT eurjchem-1667 59 19 and and CCONJ eurjchem-1667 59 20 process process NOUN eurjchem-1667 59 21 termination termination NOUN eurjchem-1667 59 22 points point NOUN eurjchem-1667 59 23 , , PUNCT eurjchem-1667 59 24 in in ADP eurjchem-1667 59 25 many many ADJ eurjchem-1667 59 26 units unit NOUN eurjchem-1667 59 27 such such ADJ eurjchem-1667 59 28 as as ADP eurjchem-1667 59 29 mixing mixing NOUN eurjchem-1667 59 30 , , PUNCT eurjchem-1667 59 31 granulation granulation NOUN eurjchem-1667 59 32 , , PUNCT eurjchem-1667 59 33 drying dry VERB eurjchem-1667 59 34 and and CCONJ eurjchem-1667 59 35 coating coat VERB eurjchem-1667 59 36 during during ADP eurjchem-1667 59 37 the the DET eurjchem-1667 59 38 production production NOUN eurjchem-1667 59 39 of of ADP eurjchem-1667 59 40 the the DET eurjchem-1667 59 41 solid solid ADJ eurjchem-1667 59 42 oral oral ADJ eurjchem-1667 59 43 dosage dosage NOUN eurjchem-1667 59 44 forms form NOUN eurjchem-1667 59 45 . . PUNCT eurjchem-1667 60 1 on on ADP eurjchem-1667 60 2 the the DET eurjchem-1667 60 3 other other ADJ eurjchem-1667 60 4 hand hand NOUN eurjchem-1667 60 5 , , PUNCT eurjchem-1667 60 6 on‐line on‐line NOUN eurjchem-1667 60 7 chromatographic chromatographic ADJ eurjchem-1667 60 8 methods method NOUN eurjchem-1667 60 9 and and CCONJ eurjchem-1667 60 10 viscosity viscosity NOUN eurjchem-1667 60 11 measurements measurement NOUN eurjchem-1667 60 12 are be AUX eurjchem-1667 60 13 other other ADJ eurjchem-1667 60 14 important important ADJ eurjchem-1667 60 15 analytical analytical ADJ eurjchem-1667 60 16 tools tool NOUN eurjchem-1667 60 17 used use VERB eurjchem-1667 60 18 in in ADP eurjchem-1667 60 19 the the DET eurjchem-1667 60 20 process process NOUN eurjchem-1667 60 21 development development NOUN eurjchem-1667 60 22 . . PUNCT eurjchem-1667 61 1 in in ADP eurjchem-1667 61 2 assessing assess VERB eurjchem-1667 61 3 the the DET eurjchem-1667 61 4 perfor‐ perfor‐ NOUN eurjchem-1667 61 5 mance mance NOUN eurjchem-1667 61 6 of of ADP eurjchem-1667 61 7 the the DET eurjchem-1667 61 8 production production NOUN eurjchem-1667 61 9 process process NOUN eurjchem-1667 61 10 , , PUNCT eurjchem-1667 61 11 chemometric chemometric ADJ eurjchem-1667 61 12 methods method NOUN eurjchem-1667 61 13 , , PUNCT eurjchem-1667 61 14 a a DET eurjchem-1667 61 15 useful useful ADJ eurjchem-1667 61 16 tool tool NOUN eurjchem-1667 61 17 for for ADP eurjchem-1667 61 18 defining define VERB eurjchem-1667 61 19 mathematical mathematical ADJ eurjchem-1667 61 20 correlation correlation NOUN eurjchem-1667 61 21 , , PUNCT eurjchem-1667 61 22 can can AUX eurjchem-1667 61 23 be be AUX eurjchem-1667 61 24 applied apply VERB eurjchem-1667 61 25 to to ADP eurjchem-1667 61 26 real‐time real‐time NOUN eurjchem-1667 61 27 monitoring monitoring NOUN eurjchem-1667 61 28 and and CCONJ eurjchem-1667 61 29 control control NOUN eurjchem-1667 61 30 to to PART eurjchem-1667 61 31 realize realize VERB eurjchem-1667 61 32 the the DET eurjchem-1667 61 33 characterization characterization NOUN eurjchem-1667 61 34 of of ADP eurjchem-1667 61 35 raw raw ADJ eurjchem-1667 61 36 and and CCONJ eurjchem-1667 61 37 intermediate intermediate ADJ eurjchem-1667 61 38 products product NOUN eurjchem-1667 61 39 [ [ X eurjchem-1667 61 40 1,14,15 1,14,15 NUM eurjchem-1667 61 41 ] ] X eurjchem-1667 61 42 . . PUNCT eurjchem-1667 62 1 432 432 NUM eurjchem-1667 62 2 calhan calhan NOUN eurjchem-1667 62 3 et et PROPN eurjchem-1667 62 4 al al PROPN eurjchem-1667 62 5 . . PUNCT eurjchem-1667 62 6 / / SYM eurjchem-1667 62 7 european european PROPN eurjchem-1667 62 8 journal journal PROPN eurjchem-1667 62 9 of of ADP eurjchem-1667 62 10 chemistry chemistry NOUN eurjchem-1667 62 11 8 8 NUM eurjchem-1667 62 12 ( ( PUNCT eurjchem-1667 62 13 4 4 NUM eurjchem-1667 62 14 ) ) PUNCT eurjchem-1667 62 15 ( ( PUNCT eurjchem-1667 62 16 2017 2017 NUM eurjchem-1667 62 17 ) ) PUNCT eurjchem-1667 62 18 430‐433 430‐433 PROPN eurjchem-1667 62 19 table table NOUN eurjchem-1667 62 20 1 1 NUM eurjchem-1667 62 21 . . PUNCT eurjchem-1667 62 22 process process NOUN eurjchem-1667 62 23 analytical analytical ADJ eurjchem-1667 62 24 technology technology NOUN eurjchem-1667 62 25 applications application NOUN eurjchem-1667 62 26 a. a. NOUN eurjchem-1667 62 27 application application NOUN eurjchem-1667 62 28 pat pat PROPN eurjchem-1667 62 29 tool tool PROPN eurjchem-1667 62 30 statistical statistical ADJ eurjchem-1667 62 31 chemometric chemometric ADJ eurjchem-1667 62 32 method method NOUN eurjchem-1667 62 33 result result NOUN eurjchem-1667 62 34 reference reference NOUN eurjchem-1667 62 35 wurster wurster NOUN eurjchem-1667 62 36 coating coating NOUN eurjchem-1667 62 37 process process NOUN eurjchem-1667 62 38 nirs nir NOUN eurjchem-1667 62 39 pls pls PROPN eurjchem-1667 62 40 can can AUX eurjchem-1667 62 41 be be AUX eurjchem-1667 62 42 used use VERB eurjchem-1667 62 43 for for ADP eurjchem-1667 62 44 monitoring monitor VERB eurjchem-1667 62 45 the the DET eurjchem-1667 62 46 wurster wurster NOUN eurjchem-1667 62 47 coating coating NOUN eurjchem-1667 62 48 process process NOUN eurjchem-1667 62 49 [ [ X eurjchem-1667 62 50 16 16 NUM eurjchem-1667 62 51 ] ] PUNCT eurjchem-1667 62 52 to to PART eurjchem-1667 62 53 compare compare VERB eurjchem-1667 62 54 quality quality NOUN eurjchem-1667 62 55 of of ADP eurjchem-1667 62 56 pharmaceutical pharmaceutical ADJ eurjchem-1667 62 57 excipient excipient PROPN eurjchem-1667 62 58 raman raman PROPN eurjchem-1667 62 59 spectroscopy spectroscopy PROPN eurjchem-1667 62 60 b b PROPN eurjchem-1667 62 61 pca pca PROPN eurjchem-1667 62 62 the the DET eurjchem-1667 62 63 proposed propose VERB eurjchem-1667 62 64 approach approach NOUN eurjchem-1667 62 65 can can AUX eurjchem-1667 62 66 form form VERB eurjchem-1667 62 67 the the DET eurjchem-1667 62 68 basis basis NOUN eurjchem-1667 62 69 for for ADP eurjchem-1667 62 70 a a DET eurjchem-1667 62 71 risk risk NOUN eurjchem-1667 62 72 reduction reduction NOUN eurjchem-1667 62 73 management management NOUN eurjchem-1667 62 74 system system NOUN eurjchem-1667 63 1 [ [ X eurjchem-1667 63 2 17 17 NUM eurjchem-1667 63 3 ] ] PUNCT eurjchem-1667 63 4 to to PART eurjchem-1667 63 5 optimize optimize VERB eurjchem-1667 63 6 a a DET eurjchem-1667 63 7 tablet tablet ADJ eurjchem-1667 63 8 formulation formulation NOUN eurjchem-1667 63 9 nirs nirs PROPN eurjchem-1667 63 10 raman raman NOUN eurjchem-1667 63 11 spectroscopy spectroscopy NOUN eurjchem-1667 63 12 pca pca PROPN eurjchem-1667 63 13 tablet tablet NOUN eurjchem-1667 63 14 formulation formulation NOUN eurjchem-1667 63 15 can can AUX eurjchem-1667 63 16 be be AUX eurjchem-1667 63 17 designed design VERB eurjchem-1667 63 18 by by ADP eurjchem-1667 63 19 using use VERB eurjchem-1667 63 20 qbd qbd PROPN eurjchem-1667 64 1 [ [ X eurjchem-1667 64 2 18 18 NUM eurjchem-1667 64 3 ] ] PUNCT eurjchem-1667 64 4 to to PART eurjchem-1667 64 5 determine determine VERB eurjchem-1667 64 6 the the DET eurjchem-1667 64 7 quantification quantification NOUN eurjchem-1667 64 8 of of ADP eurjchem-1667 64 9 active active ADJ eurjchem-1667 64 10 pharmaceutical pharmaceutical ADJ eurjchem-1667 64 11 ingredients ingredient NOUN eurjchem-1667 64 12 using use VERB eurjchem-1667 64 13 pat pat PROPN eurjchem-1667 64 14 fluorescence fluorescence NOUN eurjchem-1667 64 15 spectroscopy spectroscopy VERB eurjchem-1667 64 16 pls pls INTJ eurjchem-1667 64 17 rapid rapid ADJ eurjchem-1667 64 18 and and CCONJ eurjchem-1667 64 19 non‐destructive non‐destructive ADJ eurjchem-1667 64 20 method method NOUN eurjchem-1667 64 21 was be AUX eurjchem-1667 64 22 developed develop VERB eurjchem-1667 64 23 simultaneous simultaneous ADJ eurjchem-1667 64 24 quantification quantification NOUN eurjchem-1667 64 25 of of ADP eurjchem-1667 64 26 two two NUM eurjchem-1667 64 27 active active ADJ eurjchem-1667 64 28 pharmaceutical pharmaceutical ADJ eurjchem-1667 64 29 ingredients ingredient NOUN eurjchem-1667 64 30 in in ADP eurjchem-1667 64 31 a a DET eurjchem-1667 64 32 tablet tablet ADJ eurjchem-1667 64 33 formulation formulation NOUN eurjchem-1667 64 34 [ [ X eurjchem-1667 64 35 19 19 NUM eurjchem-1667 64 36 ] ] PUNCT eurjchem-1667 64 37 to to PART eurjchem-1667 64 38 develop develop VERB eurjchem-1667 64 39 a a DET eurjchem-1667 64 40 new new ADJ eurjchem-1667 64 41 method method NOUN eurjchem-1667 64 42 using use VERB eurjchem-1667 64 43 direct direct ADJ eurjchem-1667 64 44 analysis analysis NOUN eurjchem-1667 64 45 in in ADP eurjchem-1667 64 46 real real ADJ eurjchem-1667 64 47 time time NOUN eurjchem-1667 64 48 mass mass PROPN eurjchem-1667 64 49 spectrometry spectrometry NOUN eurjchem-1667 64 50 with with ADP eurjchem-1667 64 51 pat pat PROPN eurjchem-1667 64 52 dart‐ms dart‐ms PROPN eurjchem-1667 64 53 hplc hplc PROPN eurjchem-1667 64 54 not not PART eurjchem-1667 64 55 required require VERB eurjchem-1667 64 56 rapid rapid ADJ eurjchem-1667 64 57 process process NOUN eurjchem-1667 64 58 development development NOUN eurjchem-1667 64 59 method method NOUN eurjchem-1667 64 60 was be AUX eurjchem-1667 64 61 proposed propose VERB eurjchem-1667 64 62 using use VERB eurjchem-1667 64 63 pat pat PROPN eurjchem-1667 65 1 [ [ X eurjchem-1667 65 2 20 20 NUM eurjchem-1667 65 3 ] ] PUNCT eurjchem-1667 65 4 to to PART eurjchem-1667 65 5 investigate investigate VERB eurjchem-1667 65 6 on on ADP eurjchem-1667 65 7 line line NOUN eurjchem-1667 65 8 quantitative quantitative ADJ eurjchem-1667 65 9 monitoring monitoring NOUN eurjchem-1667 65 10 of of ADP eurjchem-1667 65 11 alcohol alcohol NOUN eurjchem-1667 65 12 precipitation precipitation NOUN eurjchem-1667 65 13 nirs nirs PROPN eurjchem-1667 65 14 pso pso NOUN eurjchem-1667 65 15 , , PUNCT eurjchem-1667 65 16 ls‐svm ls‐svm PROPN eurjchem-1667 65 17 , , PUNCT eurjchem-1667 65 18 pls pls PROPN eurjchem-1667 65 19 can can AUX eurjchem-1667 65 20 be be AUX eurjchem-1667 65 21 used use VERB eurjchem-1667 65 22 as as ADP eurjchem-1667 65 23 a a DET eurjchem-1667 65 24 process process NOUN eurjchem-1667 65 25 analyzer analyzer NOUN eurjchem-1667 65 26 for for ADP eurjchem-1667 65 27 noninvasive noninvasive ADJ eurjchem-1667 65 28 and and CCONJ eurjchem-1667 65 29 online online ADJ eurjchem-1667 65 30 quantitative quantitative ADJ eurjchem-1667 65 31 monitoring monitoring NOUN eurjchem-1667 65 32 of of ADP eurjchem-1667 65 33 alcohol alcohol NOUN eurjchem-1667 65 34 precipitation precipitation NOUN eurjchem-1667 65 35 [ [ X eurjchem-1667 65 36 21 21 NUM eurjchem-1667 65 37 ] ] PUNCT eurjchem-1667 65 38 to to PART eurjchem-1667 65 39 investigate investigate VERB eurjchem-1667 65 40 crystallization crystallization NOUN eurjchem-1667 65 41 process process NOUN eurjchem-1667 65 42 uv uv NOUN eurjchem-1667 65 43 vis vis X eurjchem-1667 65 44 c c PROPN eurjchem-1667 65 45 pca pca PROPN eurjchem-1667 65 46 pat pat NOUN eurjchem-1667 65 47 tools tool NOUN eurjchem-1667 65 48 can can AUX eurjchem-1667 65 49 be be AUX eurjchem-1667 65 50 used use VERB eurjchem-1667 65 51 to to PART eurjchem-1667 65 52 explore explore VERB eurjchem-1667 65 53 crystallization crystallization NOUN eurjchem-1667 65 54 process process NOUN eurjchem-1667 66 1 [ [ X eurjchem-1667 66 2 22 22 NUM eurjchem-1667 66 3 ] ] PUNCT eurjchem-1667 66 4 to to PART eurjchem-1667 66 5 evaluate evaluate VERB eurjchem-1667 66 6 and and CCONJ eurjchem-1667 66 7 control control VERB eurjchem-1667 66 8 the the DET eurjchem-1667 66 9 coating coating NOUN eurjchem-1667 66 10 process process NOUN eurjchem-1667 66 11 of of ADP eurjchem-1667 66 12 drug drug NOUN eurjchem-1667 66 13 nirs nir NOUN eurjchem-1667 66 14 pls pls INTJ eurjchem-1667 66 15 pat pat PROPN eurjchem-1667 66 16 can can AUX eurjchem-1667 66 17 be be AUX eurjchem-1667 66 18 used use VERB eurjchem-1667 66 19 for for ADP eurjchem-1667 66 20 drug drug NOUN eurjchem-1667 66 21 coating coating NOUN eurjchem-1667 66 22 process process NOUN eurjchem-1667 66 23 [ [ X eurjchem-1667 66 24 23 23 NUM eurjchem-1667 66 25 ] ] PUNCT eurjchem-1667 66 26 pharmaceutical pharmaceutical NOUN eurjchem-1667 66 27 granulation granulation NOUN eurjchem-1667 66 28 process process NOUN eurjchem-1667 66 29 nirs nirs PROPN eurjchem-1667 66 30 pls pls INTJ eurjchem-1667 66 31 nirs nirs PROPN eurjchem-1667 66 32 is be AUX eurjchem-1667 66 33 a a DET eurjchem-1667 66 34 useful useful ADJ eurjchem-1667 66 35 pat pat NOUN eurjchem-1667 66 36 tool tool NOUN eurjchem-1667 67 1 [ [ X eurjchem-1667 67 2 24 24 NUM eurjchem-1667 67 3 ] ] PUNCT eurjchem-1667 67 4 extraction extraction NOUN eurjchem-1667 67 5 process process NOUN eurjchem-1667 67 6 nirs nir NOUN eurjchem-1667 67 7 pls pls INTJ eurjchem-1667 67 8 successful successful ADJ eurjchem-1667 67 9 models model NOUN eurjchem-1667 67 10 have have AUX eurjchem-1667 67 11 been be AUX eurjchem-1667 67 12 built build VERB eurjchem-1667 67 13 and and CCONJ eurjchem-1667 67 14 applied apply VERB eurjchem-1667 67 15 online online ADV eurjchem-1667 67 16 for for ADP eurjchem-1667 67 17 extraction extraction NOUN eurjchem-1667 67 18 process process NOUN eurjchem-1667 67 19 [ [ X eurjchem-1667 67 20 25 25 NUM eurjchem-1667 67 21 ] ] PUNCT eurjchem-1667 67 22 a a DET eurjchem-1667 67 23 abbreviations abbreviation NOUN eurjchem-1667 67 24 : : PUNCT eurjchem-1667 67 25 nirs nir NOUN eurjchem-1667 67 26 : : PUNCT eurjchem-1667 67 27 near‐infrared near‐infrare VERB eurjchem-1667 67 28 spectroscopy spectroscopy NOUN eurjchem-1667 67 29 , , PUNCT eurjchem-1667 67 30 pls pls INTJ eurjchem-1667 67 31 : : PUNCT eurjchem-1667 67 32 partial partial ADJ eurjchem-1667 67 33 least least ADJ eurjchem-1667 67 34 squares square NOUN eurjchem-1667 67 35 , , PUNCT eurjchem-1667 67 36 pca pca PROPN eurjchem-1667 67 37 : : PUNCT eurjchem-1667 67 38 principal principal ADJ eurjchem-1667 67 39 component component NOUN eurjchem-1667 67 40 analysis analysis NOUN eurjchem-1667 67 41 , , PUNCT eurjchem-1667 67 42 qbd qbd NOUN eurjchem-1667 67 43 : : PUNCT eurjchem-1667 67 44 quality quality NOUN eurjchem-1667 67 45 by by ADP eurjchem-1667 67 46 design design NOUN eurjchem-1667 67 47 , , PUNCT eurjchem-1667 67 48 dart‐ms dart‐ms CCONJ eurjchem-1667 67 49 : : PUNCT eurjchem-1667 67 50 direct direct VERB eurjchem-1667 67 51 analysis analysis NOUN eurjchem-1667 67 52 in in ADP eurjchem-1667 67 53 real real ADJ eurjchem-1667 67 54 time time NOUN eurjchem-1667 67 55 mass mass PROPN eurjchem-1667 67 56 spectrometry spectrometry NOUN eurjchem-1667 67 57 , , PUNCT eurjchem-1667 67 58 hplc hplc NOUN eurjchem-1667 67 59 : : PUNCT eurjchem-1667 67 60 high high ADJ eurjchem-1667 67 61 performance performance NOUN eurjchem-1667 67 62 liquid liquid NOUN eurjchem-1667 67 63 chromatography chromatography NOUN eurjchem-1667 67 64 , , PUNCT eurjchem-1667 67 65 pso pso NOUN eurjchem-1667 67 66 : : PUNCT eurjchem-1667 67 67 particle particle NOUN eurjchem-1667 67 68 swarm swarm NOUN eurjchem-1667 67 69 optimization optimization NOUN eurjchem-1667 67 70 ls‐svm ls‐svm PROPN eurjchem-1667 67 71 : : PUNCT eurjchem-1667 67 72 least least ADJ eurjchem-1667 67 73 square square ADJ eurjchem-1667 67 74 support support NOUN eurjchem-1667 67 75 vector vector NOUN eurjchem-1667 67 76 machines machine NOUN eurjchem-1667 67 77 . . PUNCT eurjchem-1667 68 1 b b X eurjchem-1667 68 2 also also ADV eurjchem-1667 68 3 , , PUNCT eurjchem-1667 68 4 laser laser NOUN eurjchem-1667 68 5 diffraction diffraction NOUN eurjchem-1667 68 6 and and CCONJ eurjchem-1667 68 7 x‐ray x‐ray ADJ eurjchem-1667 68 8 powder powder NOUN eurjchem-1667 68 9 diffraction diffraction NOUN eurjchem-1667 68 10 methods method NOUN eurjchem-1667 68 11 were be AUX eurjchem-1667 68 12 used use VERB eurjchem-1667 68 13 . . PUNCT eurjchem-1667 69 1 c c X eurjchem-1667 69 2 ultra ultra ADJ eurjchem-1667 69 3 violet violet ADJ eurjchem-1667 69 4 / / SYM eurjchem-1667 69 5 visible visible ADJ eurjchem-1667 69 6 spectroscopy spectroscopy NOUN eurjchem-1667 69 7 , , PUNCT eurjchem-1667 69 8 focused focused ADJ eurjchem-1667 69 9 beam beam NOUN eurjchem-1667 69 10 reflectance reflectance NOUN eurjchem-1667 69 11 measurement measurement NOUN eurjchem-1667 69 12 ( ( PUNCT eurjchem-1667 69 13 fbrm fbrm PROPN eurjchem-1667 69 14 ) ) PUNCT eurjchem-1667 69 15 and and CCONJ eurjchem-1667 69 16 the the DET eurjchem-1667 69 17 cryprins cryprin NOUN eurjchem-1667 69 18 software software NOUN eurjchem-1667 69 19 ( ( PUNCT eurjchem-1667 69 20 crystallization crystallization NOUN eurjchem-1667 69 21 process process NOUN eurjchem-1667 69 22 informatics informatics NOUN eurjchem-1667 69 23 system system NOUN eurjchem-1667 69 24 ) ) PUNCT eurjchem-1667 69 25 . . PUNCT eurjchem-1667 70 1 1.2.3 1.2.3 X eurjchem-1667 70 2 . . PUNCT eurjchem-1667 70 3 advantages advantage NOUN eurjchem-1667 70 4 and and CCONJ eurjchem-1667 70 5 disadvantages disadvantage NOUN eurjchem-1667 70 6 of of ADP eurjchem-1667 70 7 proses proses PROPN eurjchem-1667 70 8 analytical analytical ADJ eurjchem-1667 70 9 technology technology NOUN eurjchem-1667 70 10 applications application NOUN eurjchem-1667 70 11 perhaps perhaps ADV eurjchem-1667 70 12 the the DET eurjchem-1667 70 13 most most ADV eurjchem-1667 70 14 important important ADJ eurjchem-1667 70 15 benefit benefit NOUN eurjchem-1667 70 16 of of ADP eurjchem-1667 70 17 using use VERB eurjchem-1667 70 18 the the DET eurjchem-1667 70 19 pat pat NOUN eurjchem-1667 70 20 to to ADP eurjchem-1667 70 21 the the DET eurjchem-1667 70 22 pharmaceutical pharmaceutical NOUN eurjchem-1667 70 23 industry industry NOUN eurjchem-1667 70 24 is be AUX eurjchem-1667 70 25 that that SCONJ eurjchem-1667 70 26 it it PRON eurjchem-1667 70 27 can can AUX eurjchem-1667 70 28 be be AUX eurjchem-1667 70 29 intervened intervene VERB eurjchem-1667 70 30 while while SCONJ eurjchem-1667 70 31 the the DET eurjchem-1667 70 32 processes process NOUN eurjchem-1667 70 33 are be AUX eurjchem-1667 70 34 going go VERB eurjchem-1667 70 35 on on ADP eurjchem-1667 70 36 . . PUNCT eurjchem-1667 71 1 in in ADP eurjchem-1667 71 2 other other ADJ eurjchem-1667 71 3 words word NOUN eurjchem-1667 71 4 , , PUNCT eurjchem-1667 71 5 errors error NOUN eurjchem-1667 71 6 can can AUX eurjchem-1667 71 7 be be AUX eurjchem-1667 71 8 correc‐ correc‐ NOUN eurjchem-1667 71 9 ted te VERB eurjchem-1667 71 10 while while SCONJ eurjchem-1667 71 11 the the DET eurjchem-1667 71 12 process process NOUN eurjchem-1667 71 13 is be AUX eurjchem-1667 71 14 in in ADP eurjchem-1667 71 15 progress progress NOUN eurjchem-1667 71 16 , , PUNCT eurjchem-1667 71 17 so so SCONJ eurjchem-1667 71 18 that that SCONJ eurjchem-1667 71 19 material material NOUN eurjchem-1667 71 20 losses loss NOUN eurjchem-1667 71 21 can can AUX eurjchem-1667 71 22 be be AUX eurjchem-1667 71 23 avoided avoid VERB eurjchem-1667 71 24 . . PUNCT eurjchem-1667 72 1 at at ADP eurjchem-1667 72 2 the the DET eurjchem-1667 72 3 same same ADJ eurjchem-1667 72 4 time time NOUN eurjchem-1667 72 5 , , PUNCT eurjchem-1667 72 6 since since SCONJ eurjchem-1667 72 7 the the DET eurjchem-1667 72 8 real‐time real‐time NOUN eurjchem-1667 72 9 control control NOUN eurjchem-1667 72 10 strategy strategy NOUN eurjchem-1667 72 11 is be AUX eurjchem-1667 72 12 concerned concern VERB eurjchem-1667 72 13 , , PUNCT eurjchem-1667 72 14 the the DET eurjchem-1667 72 15 production production NOUN eurjchem-1667 72 16 efficiency efficiency NOUN eurjchem-1667 72 17 can can AUX eurjchem-1667 72 18 be be AUX eurjchem-1667 72 19 achieved achieve VERB eurjchem-1667 72 20 without without ADP eurjchem-1667 72 21 sacrificing sacrifice VERB eurjchem-1667 72 22 quality quality NOUN eurjchem-1667 72 23 . . PUNCT eurjchem-1667 73 1 in in ADP eurjchem-1667 73 2 this this DET eurjchem-1667 73 3 respect respect NOUN eurjchem-1667 73 4 , , PUNCT eurjchem-1667 73 5 quality quality NOUN eurjchem-1667 73 6 and and CCONJ eurjchem-1667 73 7 stable stable ADJ eurjchem-1667 73 8 products product NOUN eurjchem-1667 73 9 can can AUX eurjchem-1667 73 10 be be AUX eurjchem-1667 73 11 produced produce VERB eurjchem-1667 73 12 in in ADP eurjchem-1667 73 13 a a DET eurjchem-1667 73 14 shorter short ADJ eurjchem-1667 73 15 period period NOUN eurjchem-1667 73 16 of of ADP eurjchem-1667 73 17 time time NOUN eurjchem-1667 73 18 , , PUNCT eurjchem-1667 73 19 in in ADP eurjchem-1667 73 20 the the DET eurjchem-1667 73 21 context context NOUN eurjchem-1667 73 22 of of ADP eurjchem-1667 73 23 better well ADJ eurjchem-1667 73 24 process process NOUN eurjchem-1667 73 25 control control NOUN eurjchem-1667 73 26 , , PUNCT eurjchem-1667 73 27 providing provide VERB eurjchem-1667 73 28 long‐ long‐ ADJ eurjchem-1667 73 29 term term NOUN eurjchem-1667 73 30 economic economic ADJ eurjchem-1667 73 31 benefits benefit NOUN eurjchem-1667 73 32 . . PUNCT eurjchem-1667 74 1 one one NUM eurjchem-1667 74 2 of of ADP eurjchem-1667 74 3 the the DET eurjchem-1667 74 4 major major ADJ eurjchem-1667 74 5 problems problem NOUN eurjchem-1667 74 6 encountered encounter VERB eurjchem-1667 74 7 with with ADP eurjchem-1667 74 8 pat pat NOUN eurjchem-1667 74 9 is be AUX eurjchem-1667 74 10 the the DET eurjchem-1667 74 11 adaptation adaptation NOUN eurjchem-1667 74 12 problem problem NOUN eurjchem-1667 74 13 during during ADP eurjchem-1667 74 14 the the DET eurjchem-1667 74 15 integration integration NOUN eurjchem-1667 74 16 of of ADP eurjchem-1667 74 17 the the DET eurjchem-1667 74 18 applications application NOUN eurjchem-1667 74 19 based base VERB eurjchem-1667 74 20 on on ADP eurjchem-1667 74 21 quality quality NOUN eurjchem-1667 74 22 and and CCONJ eurjchem-1667 74 23 design design NOUN eurjchem-1667 74 24 and and CCONJ eurjchem-1667 74 25 pat pat NOUN eurjchem-1667 74 26 approach approach NOUN eurjchem-1667 74 27 into into ADP eurjchem-1667 74 28 the the DET eurjchem-1667 74 29 existing exist VERB eurjchem-1667 74 30 system system NOUN eurjchem-1667 74 31 . . PUNCT eurjchem-1667 75 1 it it PRON eurjchem-1667 75 2 is be AUX eurjchem-1667 75 3 clear clear ADJ eurjchem-1667 75 4 that that SCONJ eurjchem-1667 75 5 revision revision NOUN eurjchem-1667 75 6 of of ADP eurjchem-1667 75 7 the the DET eurjchem-1667 75 8 traditional traditional ADJ eurjchem-1667 75 9 phar‐ phar‐ NOUN eurjchem-1667 75 10 maceutical maceutical ADJ eurjchem-1667 75 11 product product NOUN eurjchem-1667 75 12 development development NOUN eurjchem-1667 75 13 process process NOUN eurjchem-1667 75 14 already already ADV eurjchem-1667 75 15 in in ADP eurjchem-1667 75 16 place place NOUN eurjchem-1667 75 17 needs need VERB eurjchem-1667 75 18 a a DET eurjchem-1667 75 19 major major ADJ eurjchem-1667 75 20 role role NOUN eurjchem-1667 75 21 played play VERB eurjchem-1667 75 22 by by ADP eurjchem-1667 75 23 official official ADJ eurjchem-1667 75 24 authorities authority NOUN eurjchem-1667 75 25 , , PUNCT eurjchem-1667 75 26 applicants applicant NOUN eurjchem-1667 75 27 , , PUNCT eurjchem-1667 75 28 and and CCONJ eurjchem-1667 75 29 sectorial sectorial ADJ eurjchem-1667 75 30 employees employee NOUN eurjchem-1667 75 31 . . PUNCT eurjchem-1667 76 1 this this PRON eurjchem-1667 76 2 is be AUX eurjchem-1667 76 3 because because SCONJ eurjchem-1667 76 4 there there PRON eurjchem-1667 76 5 is be VERB eurjchem-1667 76 6 a a DET eurjchem-1667 76 7 need need NOUN eurjchem-1667 76 8 for for ADP eurjchem-1667 76 9 training training NOUN eurjchem-1667 76 10 and and CCONJ eurjchem-1667 76 11 working work VERB eurjchem-1667 76 12 devotedly devotedly ADV eurjchem-1667 76 13 at at ADP eurjchem-1667 76 14 every every DET eurjchem-1667 76 15 step step NOUN eurjchem-1667 76 16 to to PART eurjchem-1667 76 17 build build VERB eurjchem-1667 76 18 this this DET eurjchem-1667 76 19 understanding understanding NOUN eurjchem-1667 76 20 based base VERB eurjchem-1667 76 21 on on ADP eurjchem-1667 76 22 quality quality NOUN eurjchem-1667 76 23 building building NOUN eurjchem-1667 76 24 and and CCONJ eurjchem-1667 76 25 to to PART eurjchem-1667 76 26 revise revise VERB eurjchem-1667 76 27 the the DET eurjchem-1667 76 28 existing exist VERB eurjchem-1667 76 29 traditional traditional ADJ eurjchem-1667 76 30 approach approach NOUN eurjchem-1667 76 31 . . PUNCT eurjchem-1667 77 1 moreover moreover ADV eurjchem-1667 77 2 , , PUNCT eurjchem-1667 77 3 it it PRON eurjchem-1667 77 4 is be AUX eurjchem-1667 77 5 necessary necessary ADJ eurjchem-1667 77 6 to to PART eurjchem-1667 77 7 develop develop VERB eurjchem-1667 77 8 measurement measurement NOUN eurjchem-1667 77 9 tools tool NOUN eurjchem-1667 77 10 and and CCONJ eurjchem-1667 77 11 data datum NOUN eurjchem-1667 77 12 analysis analysis NOUN eurjchem-1667 77 13 methods method NOUN eurjchem-1667 77 14 in in ADP eurjchem-1667 77 15 order order NOUN eurjchem-1667 77 16 to to PART eurjchem-1667 77 17 better well ADV eurjchem-1667 77 18 understand understand VERB eurjchem-1667 77 19 the the DET eurjchem-1667 77 20 chemical chemical NOUN eurjchem-1667 77 21 and and CCONJ eurjchem-1667 77 22 pharmaceutical pharmaceutical NOUN eurjchem-1667 77 23 processes process NOUN eurjchem-1667 77 24 and and CCONJ eurjchem-1667 77 25 to to PART eurjchem-1667 77 26 understand understand VERB eurjchem-1667 77 27 their their PRON eurjchem-1667 77 28 contribution contribution NOUN eurjchem-1667 77 29 to to ADP eurjchem-1667 77 30 quality quality NOUN eurjchem-1667 77 31 . . PUNCT eurjchem-1667 78 1 2 2 X eurjchem-1667 78 2 . . X eurjchem-1667 78 3 applications application NOUN eurjchem-1667 78 4 of of ADP eurjchem-1667 78 5 proses proses PROPN eurjchem-1667 78 6 analytical analytical ADJ eurjchem-1667 78 7 technology technology NOUN eurjchem-1667 78 8 in in ADP eurjchem-1667 78 9 drug drug NOUN eurjchem-1667 78 10 industry industry NOUN eurjchem-1667 78 11 as as ADP eurjchem-1667 78 12 part part NOUN eurjchem-1667 78 13 of of ADP eurjchem-1667 78 14 quality quality NOUN eurjchem-1667 78 15 by by ADP eurjchem-1667 78 16 design design NOUN eurjchem-1667 78 17 pat pat NOUN eurjchem-1667 78 18 is be AUX eurjchem-1667 78 19 used use VERB eurjchem-1667 78 20 in in ADP eurjchem-1667 78 21 different different ADJ eurjchem-1667 78 22 fields field NOUN eurjchem-1667 78 23 of of ADP eurjchem-1667 78 24 the the DET eurjchem-1667 78 25 pharmaceutical pharmaceutical ADJ eurjchem-1667 78 26 industry industry NOUN eurjchem-1667 78 27 such such ADJ eurjchem-1667 78 28 as as ADP eurjchem-1667 78 29 extraction extraction NOUN eurjchem-1667 78 30 and and CCONJ eurjchem-1667 78 31 crystallization crystallization NOUN eurjchem-1667 78 32 processes process NOUN eurjchem-1667 78 33 , , PUNCT eurjchem-1667 78 34 production production NOUN eurjchem-1667 78 35 of of ADP eurjchem-1667 78 36 solid solid ADJ eurjchem-1667 78 37 dosage dosage NOUN eurjchem-1667 78 38 forms form NOUN eurjchem-1667 78 39 , , PUNCT eurjchem-1667 78 40 tablet tablet NOUN eurjchem-1667 78 41 pressing pressing ADJ eurjchem-1667 78 42 , , PUNCT eurjchem-1667 78 43 quantify‐ quantify‐ ADJ eurjchem-1667 78 44 cation cation NOUN eurjchem-1667 78 45 of of ADP eurjchem-1667 78 46 active active ADJ eurjchem-1667 78 47 and and CCONJ eurjchem-1667 78 48 auxiliary auxiliary ADJ eurjchem-1667 78 49 substances substance NOUN eurjchem-1667 78 50 , , PUNCT eurjchem-1667 78 51 blending blending NOUN eurjchem-1667 78 52 , , PUNCT eurjchem-1667 78 53 granula‐ granula‐ NOUN eurjchem-1667 78 54 tion tion NOUN eurjchem-1667 78 55 , , PUNCT eurjchem-1667 78 56 and and CCONJ eurjchem-1667 78 57 coating coating NOUN eurjchem-1667 78 58 processes process NOUN eurjchem-1667 78 59 . . PUNCT eurjchem-1667 79 1 in in ADP eurjchem-1667 79 2 this this DET eurjchem-1667 79 3 context context NOUN eurjchem-1667 79 4 , , PUNCT eurjchem-1667 79 5 examples example NOUN eurjchem-1667 79 6 of of ADP eurjchem-1667 79 7 differ‐ differ‐ PROPN eurjchem-1667 79 8 rent rent NOUN eurjchem-1667 79 9 pat pat NOUN eurjchem-1667 79 10 applications application NOUN eurjchem-1667 79 11 used use VERB eurjchem-1667 79 12 in in ADP eurjchem-1667 79 13 the the DET eurjchem-1667 79 14 pharmaceutical pharmaceutical NOUN eurjchem-1667 79 15 industry industry NOUN eurjchem-1667 79 16 are be AUX eurjchem-1667 79 17 given give VERB eurjchem-1667 79 18 in in ADP eurjchem-1667 79 19 table table NOUN eurjchem-1667 79 20 1 1 NUM eurjchem-1667 79 21 . . PUNCT eurjchem-1667 79 22 naidu naidu PROPN eurjchem-1667 79 23 et et PROPN eurjchem-1667 79 24 al al PROPN eurjchem-1667 79 25 . . PUNCT eurjchem-1667 80 1 [ [ X eurjchem-1667 80 2 16 16 NUM eurjchem-1667 80 3 ] ] PUNCT eurjchem-1667 80 4 aimed aim VERB eurjchem-1667 80 5 improving improve VERB eurjchem-1667 80 6 understanding understanding NOUN eurjchem-1667 80 7 of of ADP eurjchem-1667 80 8 multi‐ multi‐ PROPN eurjchem-1667 80 9 particulate particulate NOUN eurjchem-1667 80 10 drug drug NOUN eurjchem-1667 80 11 delivery delivery NOUN eurjchem-1667 80 12 system system NOUN eurjchem-1667 80 13 by by ADP eurjchem-1667 80 14 monitoring monitor VERB eurjchem-1667 80 15 percent percent NOUN eurjchem-1667 80 16 weight weight NOUN eurjchem-1667 80 17 build‐up build‐up NUM eurjchem-1667 80 18 during during ADP eurjchem-1667 80 19 the the DET eurjchem-1667 80 20 functional functional ADJ eurjchem-1667 80 21 coating coating NOUN eurjchem-1667 80 22 process process NOUN eurjchem-1667 80 23 of of ADP eurjchem-1667 80 24 drug‐loaded drug‐loade VERB eurjchem-1667 80 25 pellets pellet NOUN eurjchem-1667 80 26 within within ADP eurjchem-1667 80 27 qbd qbd NOUN eurjchem-1667 80 28 framework framework NOUN eurjchem-1667 80 29 . . PUNCT eurjchem-1667 81 1 an an DET eurjchem-1667 81 2 at‐line at‐line PROPN eurjchem-1667 81 3 nir nir ADJ eurjchem-1667 81 4 spectroscopy spectroscopy NOUN eurjchem-1667 81 5 was be AUX eurjchem-1667 81 6 used use VERB eurjchem-1667 81 7 as as ADP eurjchem-1667 81 8 pat pat PROPN eurjchem-1667 81 9 tool tool PROPN eurjchem-1667 81 10 . . PUNCT eurjchem-1667 82 1 the the DET eurjchem-1667 82 2 authors author NOUN eurjchem-1667 82 3 reported report VERB eurjchem-1667 82 4 that that SCONJ eurjchem-1667 82 5 they they PRON eurjchem-1667 82 6 deve‐ deve‐ PROPN eurjchem-1667 82 7 loped lope VERB eurjchem-1667 82 8 an an DET eurjchem-1667 82 9 at‐line at‐line PROPN eurjchem-1667 82 10 nir nir NOUN eurjchem-1667 82 11 spectroscopy spectroscopy NOUN eurjchem-1667 82 12 method method NOUN eurjchem-1667 82 13 for for ADP eurjchem-1667 82 14 monitoring monitor VERB eurjchem-1667 82 15 the the DET eurjchem-1667 82 16 progress progress NOUN eurjchem-1667 82 17 of of ADP eurjchem-1667 82 18 wurster wurster NOUN eurjchem-1667 82 19 coating coating NOUN eurjchem-1667 82 20 operation operation NOUN eurjchem-1667 82 21 without without ADP eurjchem-1667 82 22 contacting contact VERB eurjchem-1667 82 23 and and CCONJ eurjchem-1667 82 24 destructing destruct VERB eurjchem-1667 82 25 the the DET eurjchem-1667 82 26 sample sample NOUN eurjchem-1667 82 27 . . PUNCT eurjchem-1667 83 1 hertrampf hertrampf NOUN eurjchem-1667 83 2 et et PROPN eurjchem-1667 83 3 al al PROPN eurjchem-1667 83 4 . . PUNCT eurjchem-1667 84 1 [ [ X eurjchem-1667 84 2 17 17 NUM eurjchem-1667 84 3 ] ] PUNCT eurjchem-1667 84 4 compared compare VERB eurjchem-1667 84 5 the the DET eurjchem-1667 84 6 quality quality NOUN eurjchem-1667 84 7 of of ADP eurjchem-1667 84 8 pharmaceu‐ pharmaceu‐ PROPN eurjchem-1667 84 9 tical tical ADJ eurjchem-1667 84 10 excipients excipient NOUN eurjchem-1667 84 11 , , PUNCT eurjchem-1667 84 12 manufactured manufacture VERB eurjchem-1667 84 13 on on ADP eurjchem-1667 84 14 three three NUM eurjchem-1667 84 15 different different ADJ eurjchem-1667 84 16 production production NOUN eurjchem-1667 84 17 lines line NOUN eurjchem-1667 84 18 . . PUNCT eurjchem-1667 85 1 they they PRON eurjchem-1667 85 2 aimed aim VERB eurjchem-1667 85 3 to to PART eurjchem-1667 85 4 identify identify VERB eurjchem-1667 85 5 which which DET eurjchem-1667 85 6 continuous continuous ADJ eurjchem-1667 85 7 process process NOUN eurjchem-1667 85 8 ensu‐ ensu‐ NOUN eurjchem-1667 85 9 res re VERB eurjchem-1667 85 10 a a DET eurjchem-1667 85 11 similar similar ADJ eurjchem-1667 85 12 product product NOUN eurjchem-1667 85 13 quality quality NOUN eurjchem-1667 85 14 to to ADP eurjchem-1667 85 15 that that PRON eurjchem-1667 85 16 of of ADP eurjchem-1667 85 17 batch batch NOUN eurjchem-1667 85 18 processing processing NOUN eurjchem-1667 85 19 . . PUNCT eurjchem-1667 86 1 for for ADP eurjchem-1667 86 2 this this DET eurjchem-1667 86 3 purpose purpose NOUN eurjchem-1667 86 4 , , PUNCT eurjchem-1667 86 5 different different ADJ eurjchem-1667 86 6 analytical analytical ADJ eurjchem-1667 86 7 methods method NOUN eurjchem-1667 86 8 were be AUX eurjchem-1667 86 9 used use VERB eurjchem-1667 86 10 . . PUNCT eurjchem-1667 87 1 authors author NOUN eurjchem-1667 87 2 reported report VERB eurjchem-1667 87 3 that that SCONJ eurjchem-1667 87 4 the the DET eurjchem-1667 87 5 proposed propose VERB eurjchem-1667 87 6 approach approach NOUN eurjchem-1667 87 7 can can AUX eurjchem-1667 87 8 form form VERB eurjchem-1667 87 9 the the DET eurjchem-1667 87 10 basis basis NOUN eurjchem-1667 87 11 for for ADP eurjchem-1667 87 12 a a DET eurjchem-1667 87 13 risk risk NOUN eurjchem-1667 87 14 reduction reduction NOUN eurjchem-1667 87 15 and and CCONJ eurjchem-1667 87 16 management management NOUN eurjchem-1667 87 17 system system NOUN eurjchem-1667 87 18 with with ADP eurjchem-1667 87 19 regard regard NOUN eurjchem-1667 87 20 to to ADP eurjchem-1667 87 21 sourcing sourcing NOUN eurjchem-1667 87 22 and and CCONJ eurjchem-1667 87 23 manufacturability manufacturability NOUN eurjchem-1667 87 24 . . PUNCT eurjchem-1667 88 1 chavez chavez PROPN eurjchem-1667 88 2 et et PROPN eurjchem-1667 88 3 al al PROPN eurjchem-1667 88 4 . . PUNCT eurjchem-1667 89 1 [ [ X eurjchem-1667 89 2 18 18 NUM eurjchem-1667 89 3 ] ] PUNCT eurjchem-1667 89 4 studied study VERB eurjchem-1667 89 5 to to PART eurjchem-1667 89 6 optimize optimize VERB eurjchem-1667 89 7 the the DET eurjchem-1667 89 8 tablet tablet NOUN eurjchem-1667 89 9 formula‐ formula‐ NUM eurjchem-1667 89 10 tion tion NOUN eurjchem-1667 89 11 using use VERB eurjchem-1667 89 12 qbd qbd NOUN eurjchem-1667 89 13 approach approach NOUN eurjchem-1667 89 14 . . PUNCT eurjchem-1667 90 1 for for ADP eurjchem-1667 90 2 this this DET eurjchem-1667 90 3 purpose purpose NOUN eurjchem-1667 90 4 , , PUNCT eurjchem-1667 90 5 fourier fourier NOUN eurjchem-1667 90 6 transform transform VERB eurjchem-1667 90 7 infrared infrared ADJ eurjchem-1667 90 8 and and CCONJ eurjchem-1667 90 9 raman raman NOUN eurjchem-1667 90 10 spectroscopy spectroscopy NOUN eurjchem-1667 90 11 instruments instrument NOUN eurjchem-1667 90 12 were be AUX eurjchem-1667 90 13 used use VERB eurjchem-1667 90 14 as as ADP eurjchem-1667 90 15 pat pat NOUN eurjchem-1667 90 16 tools tool NOUN eurjchem-1667 90 17 . . PUNCT eurjchem-1667 91 1 the the DET eurjchem-1667 91 2 authors author NOUN eurjchem-1667 91 3 analyzed analyze VERB eurjchem-1667 91 4 the the DET eurjchem-1667 91 5 data datum NOUN eurjchem-1667 91 6 by by ADP eurjchem-1667 91 7 principal principal ADJ eurjchem-1667 91 8 compo‐ compo‐ PROPN eurjchem-1667 91 9 nent nent NOUN eurjchem-1667 91 10 analysis analysis NOUN eurjchem-1667 91 11 . . PUNCT eurjchem-1667 92 1 warnecke warnecke NOUN eurjchem-1667 92 2 et et PROPN eurjchem-1667 92 3 al al PROPN eurjchem-1667 92 4 . . PUNCT eurjchem-1667 93 1 [ [ X eurjchem-1667 93 2 19 19 NUM eurjchem-1667 93 3 ] ] PUNCT eurjchem-1667 93 4 aimed aim VERB eurjchem-1667 93 5 to to PART eurjchem-1667 93 6 determine determine VERB eurjchem-1667 93 7 the the DET eurjchem-1667 93 8 quantification quantification NOUN eurjchem-1667 93 9 of of ADP eurjchem-1667 93 10 active active ADJ eurjchem-1667 93 11 pharmaceutical pharmaceutical ADJ eurjchem-1667 93 12 ingredients ingredient NOUN eurjchem-1667 93 13 using use VERB eurjchem-1667 93 14 process process NOUN eurjchem-1667 93 15 analytical analytical ADJ eurjchem-1667 93 16 technology technology NOUN eurjchem-1667 93 17 . . PUNCT eurjchem-1667 94 1 the the DET eurjchem-1667 94 2 samples sample NOUN eurjchem-1667 94 3 were be AUX eurjchem-1667 94 4 analyzed analyze VERB eurjchem-1667 94 5 by by ADP eurjchem-1667 94 6 fluorescence fluorescence NOUN eurjchem-1667 94 7 spect‐ spect‐ AUX eurjchem-1667 94 8 roscopy roscopy NOUN eurjchem-1667 94 9 and and CCONJ eurjchem-1667 94 10 the the DET eurjchem-1667 94 11 data datum NOUN eurjchem-1667 94 12 analysis analysis NOUN eurjchem-1667 94 13 was be AUX eurjchem-1667 94 14 performed perform VERB eurjchem-1667 94 15 using use VERB eurjchem-1667 94 16 a a DET eurjchem-1667 94 17 partial partial ADJ eurjchem-1667 94 18 least least ADJ eurjchem-1667 94 19 squares square NOUN eurjchem-1667 94 20 regression regression NOUN eurjchem-1667 94 21 . . PUNCT eurjchem-1667 95 1 in in ADP eurjchem-1667 95 2 addition addition NOUN eurjchem-1667 95 3 , , PUNCT eurjchem-1667 95 4 the the DET eurjchem-1667 95 5 goal goal NOUN eurjchem-1667 95 6 of of ADP eurjchem-1667 95 7 the the DET eurjchem-1667 95 8 study study NOUN eurjchem-1667 95 9 conducted conduct VERB eurjchem-1667 95 10 by by ADP eurjchem-1667 95 11 yan yan PROPN eurjchem-1667 95 12 et et PROPN eurjchem-1667 95 13 al al PROPN eurjchem-1667 95 14 . . PUNCT eurjchem-1667 96 1 [ [ X eurjchem-1667 96 2 20 20 NUM eurjchem-1667 96 3 ] ] PUNCT eurjchem-1667 96 4 was be AUX eurjchem-1667 96 5 set set VERB eurjchem-1667 96 6 to to PART eurjchem-1667 96 7 develop develop VERB eurjchem-1667 96 8 a a DET eurjchem-1667 96 9 new new ADJ eurjchem-1667 96 10 method method NOUN eurjchem-1667 96 11 using use VERB eurjchem-1667 96 12 direct direct ADJ eurjchem-1667 96 13 analysis analysis NOUN eurjchem-1667 96 14 in in ADP eurjchem-1667 96 15 real real ADJ eurjchem-1667 96 16 time time NOUN eurjchem-1667 96 17 mass mass NOUN eurjchem-1667 96 18 spectrometry spectrometry NOUN eurjchem-1667 96 19 as as ADP eurjchem-1667 96 20 a a DET eurjchem-1667 96 21 pat pat NOUN eurjchem-1667 96 22 tool tool NOUN eurjchem-1667 96 23 . . PUNCT eurjchem-1667 97 1 based base VERB eurjchem-1667 97 2 on on ADP eurjchem-1667 97 3 this this DET eurjchem-1667 97 4 pat pat NOUN eurjchem-1667 97 5 tool tool PROPN eurjchem-1667 97 6 , , PUNCT eurjchem-1667 97 7 the the DET eurjchem-1667 97 8 impacts impact NOUN eurjchem-1667 97 9 of of ADP eurjchem-1667 97 10 process process NOUN eurjchem-1667 97 11 parameters parameter NOUN eurjchem-1667 97 12 on on ADP eurjchem-1667 97 13 the the DET eurjchem-1667 97 14 adsorption adsorption NOUN eurjchem-1667 97 15 capacity capacity NOUN eurjchem-1667 97 16 were be AUX eurjchem-1667 97 17 discovered discover VERB eurjchem-1667 97 18 rapidly rapidly ADV eurjchem-1667 97 19 . . PUNCT eurjchem-1667 98 1 the the DET eurjchem-1667 98 2 authors author NOUN eurjchem-1667 98 3 reported report VERB eurjchem-1667 98 4 that that SCONJ eurjchem-1667 98 5 the the DET eurjchem-1667 98 6 proposed propose VERB eurjchem-1667 98 7 approach approach NOUN eurjchem-1667 98 8 was be AUX eurjchem-1667 98 9 model model NOUN eurjchem-1667 98 10 free free ADJ eurjchem-1667 98 11 and and CCONJ eurjchem-1667 98 12 did do AUX eurjchem-1667 98 13 not not PART eurjchem-1667 98 14 require require VERB eurjchem-1667 98 15 use use NOUN eurjchem-1667 98 16 of of ADP eurjchem-1667 98 17 any any DET eurjchem-1667 98 18 calibration calibration NOUN eurjchem-1667 98 19 model model NOUN eurjchem-1667 98 20 . . PUNCT eurjchem-1667 99 1 jin jin PROPN eurjchem-1667 99 2 et et PROPN eurjchem-1667 99 3 al al PROPN eurjchem-1667 99 4 . . PUNCT eurjchem-1667 100 1 [ [ X eurjchem-1667 100 2 21 21 NUM eurjchem-1667 100 3 ] ] PUNCT eurjchem-1667 100 4 aimed aim VERB eurjchem-1667 100 5 to to PART eurjchem-1667 100 6 use use VERB eurjchem-1667 100 7 nir nir ADJ eurjchem-1667 100 8 spectroscopy spectroscopy NOUN eurjchem-1667 100 9 for for ADP eurjchem-1667 100 10 online online ADJ eurjchem-1667 100 11 and and CCONJ eurjchem-1667 100 12 real real ADJ eurjchem-1667 100 13 time time NOUN eurjchem-1667 100 14 quantitative quantitative ADJ eurjchem-1667 100 15 monitoring monitoring NOUN eurjchem-1667 100 16 of of ADP eurjchem-1667 100 17 alcohol alcohol NOUN eurjchem-1667 100 18 precipitation precipitation NOUN eurjchem-1667 100 19 . . PUNCT eurjchem-1667 101 1 the the DET eurjchem-1667 101 2 developed develop VERB eurjchem-1667 101 3 nir nir ADJ eurjchem-1667 101 4 models model NOUN eurjchem-1667 101 5 were be AUX eurjchem-1667 101 6 successfully successfully ADV eurjchem-1667 101 7 applied apply VERB eurjchem-1667 101 8 for for ADP eurjchem-1667 101 9 quanti‐ quanti‐ PROPN eurjchem-1667 101 10 tative tative NOUN eurjchem-1667 101 11 analysis analysis NOUN eurjchem-1667 101 12 of of ADP eurjchem-1667 101 13 the the DET eurjchem-1667 101 14 critical critical ADJ eurjchem-1667 101 15 intermediate intermediate ADJ eurjchem-1667 101 16 quality quality NOUN eurjchem-1667 101 17 attributes attribute NOUN eurjchem-1667 101 18 during during ADP eurjchem-1667 101 19 alcohol alcohol NOUN eurjchem-1667 101 20 precipitation precipitation NOUN eurjchem-1667 101 21 . . PUNCT eurjchem-1667 102 1 simone simone NOUN eurjchem-1667 102 2 et et PROPN eurjchem-1667 102 3 al al PROPN eurjchem-1667 102 4 . . PUNCT eurjchem-1667 103 1 [ [ X eurjchem-1667 103 2 22 22 NUM eurjchem-1667 103 3 ] ] PUNCT eurjchem-1667 103 4 designed design VERB eurjchem-1667 103 5 their their PRON eurjchem-1667 103 6 study study NOUN eurjchem-1667 103 7 to to PART eurjchem-1667 103 8 illustrate illustrate VERB eurjchem-1667 103 9 how how SCONJ eurjchem-1667 103 10 an an DET eurjchem-1667 103 11 array array NOUN eurjchem-1667 103 12 pat pat NOUN eurjchem-1667 103 13 tool tool PROPN eurjchem-1667 103 14 could could AUX eurjchem-1667 103 15 be be AUX eurjchem-1667 103 16 used use VERB eurjchem-1667 103 17 at at ADP eurjchem-1667 103 18 the the DET eurjchem-1667 103 19 crystallization crystallization NOUN eurjchem-1667 103 20 process process NOUN eurjchem-1667 103 21 of of ADP eurjchem-1667 103 22 a a DET eurjchem-1667 103 23 biopharmaceutical biopharmaceutical NOUN eurjchem-1667 103 24 compound compound NOUN eurjchem-1667 103 25 in in ADP eurjchem-1667 103 26 the the DET eurjchem-1667 103 27 presence presence NOUN eurjchem-1667 103 28 of of ADP eurjchem-1667 103 29 impurities impurity NOUN eurjchem-1667 103 30 . . PUNCT eurjchem-1667 104 1 the the DET eurjchem-1667 104 2 authors author NOUN eurjchem-1667 104 3 used use VERB eurjchem-1667 104 4 different different ADJ eurjchem-1667 104 5 pat pat NOUN eurjchem-1667 104 6 tools tool NOUN eurjchem-1667 104 7 to to PART eurjchem-1667 104 8 learn learn VERB eurjchem-1667 104 9 crystallization crystallization NOUN eurjchem-1667 104 10 process process NOUN eurjchem-1667 104 11 of of ADP eurjchem-1667 104 12 the the DET eurjchem-1667 104 13 biopharmaceutical biopharmaceutical NOUN eurjchem-1667 104 14 compound compound NOUN eurjchem-1667 104 15 . . PUNCT eurjchem-1667 105 1 kim kim PROPN eurjchem-1667 105 2 et et PROPN eurjchem-1667 105 3 al al PROPN eurjchem-1667 105 4 . . PUNCT eurjchem-1667 106 1 [ [ X eurjchem-1667 106 2 23 23 NUM eurjchem-1667 106 3 ] ] PUNCT eurjchem-1667 106 4 purposed purpose VERB eurjchem-1667 106 5 to to PART eurjchem-1667 106 6 develop develop VERB eurjchem-1667 106 7 a a DET eurjchem-1667 106 8 validated validate VERB eurjchem-1667 106 9 nirs nir NOUN eurjchem-1667 106 10 met‐ met‐ VERB eurjchem-1667 106 11 hod hod NOUN eurjchem-1667 106 12 for for ADP eurjchem-1667 106 13 evaluating evaluate VERB eurjchem-1667 106 14 and and CCONJ eurjchem-1667 106 15 controlling control VERB eurjchem-1667 106 16 the the DET eurjchem-1667 106 17 tablet tablet NOUN eurjchem-1667 106 18 coating coating NOUN eurjchem-1667 106 19 process process NOUN eurjchem-1667 106 20 of of ADP eurjchem-1667 106 21 a a DET eurjchem-1667 106 22 drug drug NOUN eurjchem-1667 106 23 with with ADP eurjchem-1667 106 24 low low ADJ eurjchem-1667 106 25 therapeutic therapeutic ADJ eurjchem-1667 106 26 dose dose NOUN eurjchem-1667 106 27 , , PUNCT eurjchem-1667 106 28 glimepiride glimepiride NOUN eurjchem-1667 106 29 . . PUNCT eurjchem-1667 107 1 calhan calhan PROPN eurjchem-1667 107 2 et et PROPN eurjchem-1667 107 3 al al PROPN eurjchem-1667 107 4 . . PUNCT eurjchem-1667 107 5 / / SYM eurjchem-1667 107 6 european european PROPN eurjchem-1667 107 7 journal journal PROPN eurjchem-1667 107 8 of of ADP eurjchem-1667 107 9 chemistry chemistry NOUN eurjchem-1667 107 10 8 8 NUM eurjchem-1667 107 11 ( ( PUNCT eurjchem-1667 107 12 4 4 NUM eurjchem-1667 107 13 ) ) PUNCT eurjchem-1667 107 14 ( ( PUNCT eurjchem-1667 107 15 2017 2017 NUM eurjchem-1667 107 16 ) ) PUNCT eurjchem-1667 107 17 430‐433 430‐433 PROPN eurjchem-1667 107 18 433 433 NUM eurjchem-1667 107 19 rosas rosa NOUN eurjchem-1667 107 20 et et PROPN eurjchem-1667 107 21 al al PROPN eurjchem-1667 107 22 . . PUNCT eurjchem-1667 108 1 [ [ X eurjchem-1667 108 2 24 24 NUM eurjchem-1667 108 3 ] ] PUNCT eurjchem-1667 108 4 developed develop VERB eurjchem-1667 108 5 a a DET eurjchem-1667 108 6 method method NOUN eurjchem-1667 108 7 for for ADP eurjchem-1667 108 8 the the DET eurjchem-1667 108 9 non‐invasive non‐invasive ADJ eurjchem-1667 108 10 determination determination NOUN eurjchem-1667 108 11 of of ADP eurjchem-1667 108 12 the the DET eurjchem-1667 108 13 critical critical ADJ eurjchem-1667 108 14 quality quality NOUN eurjchem-1667 108 15 attributes attribute NOUN eurjchem-1667 108 16 ( ( PUNCT eurjchem-1667 108 17 cqas cqas NOUN eurjchem-1667 108 18 ) ) PUNCT eurjchem-1667 108 19 of of ADP eurjchem-1667 108 20 a a DET eurjchem-1667 108 21 pharmaceutical pharmaceutical ADJ eurjchem-1667 108 22 granulate granulate NOUN eurjchem-1667 108 23 with with ADP eurjchem-1667 108 24 a a DET eurjchem-1667 108 25 view view NOUN eurjchem-1667 108 26 to to PART eurjchem-1667 108 27 reduce reduce VERB eurjchem-1667 108 28 its its PRON eurjchem-1667 108 29 manufac‐ manufac‐ NOUN eurjchem-1667 108 30 turing ture VERB eurjchem-1667 108 31 time time NOUN eurjchem-1667 108 32 and and CCONJ eurjchem-1667 108 33 to to PART eurjchem-1667 108 34 obtain obtain VERB eurjchem-1667 108 35 a a DET eurjchem-1667 108 36 better well ADJ eurjchem-1667 108 37 knowledge knowledge NOUN eurjchem-1667 108 38 of of ADP eurjchem-1667 108 39 the the DET eurjchem-1667 108 40 effects effect NOUN eurjchem-1667 108 41 of of ADP eurjchem-1667 108 42 some some DET eurjchem-1667 108 43 variables variable NOUN eurjchem-1667 108 44 used use VERB eurjchem-1667 108 45 in in ADP eurjchem-1667 108 46 the the DET eurjchem-1667 108 47 production production NOUN eurjchem-1667 108 48 process process NOUN eurjchem-1667 108 49 . . PUNCT eurjchem-1667 109 1 they they PRON eurjchem-1667 109 2 reported report VERB eurjchem-1667 109 3 that that SCONJ eurjchem-1667 109 4 near near ADV eurjchem-1667 109 5 infrared infrared ADJ eurjchem-1667 109 6 spectroscopy spectroscopy NOUN eurjchem-1667 109 7 ( ( PUNCT eurjchem-1667 109 8 nirs nirs PROPN eurjchem-1667 109 9 ) ) PUNCT eurjchem-1667 109 10 has have AUX eurjchem-1667 109 11 been be AUX eurjchem-1667 109 12 successfully successfully ADV eurjchem-1667 109 13 used use VERB eurjchem-1667 109 14 to to PART eurjchem-1667 109 15 develop develop VERB eurjchem-1667 109 16 faster fast ADJ eurjchem-1667 109 17 and and CCONJ eurjchem-1667 109 18 non‐invasive non‐invasive ADJ eurjchem-1667 109 19 quantitative quantitative ADJ eurjchem-1667 109 20 methods method NOUN eurjchem-1667 109 21 for for ADP eurjchem-1667 109 22 real‐time real‐time NOUN eurjchem-1667 109 23 prediction prediction NOUN eurjchem-1667 109 24 of of ADP eurjchem-1667 109 25 the the DET eurjchem-1667 109 26 critical critical ADJ eurjchem-1667 109 27 quality quality NOUN eurjchem-1667 109 28 attributes attribute NOUN eurjchem-1667 109 29 ( ( PUNCT eurjchem-1667 109 30 cqa cqa NOUN eurjchem-1667 109 31 ) ) PUNCT eurjchem-1667 109 32 of of ADP eurjchem-1667 109 33 pharmaceutical pharmaceutical NOUN eurjchem-1667 109 34 granulates granulate NOUN eurjchem-1667 109 35 ( ( PUNCT eurjchem-1667 109 36 api api NOUN eurjchem-1667 109 37 content content NOUN eurjchem-1667 109 38 , , PUNCT eurjchem-1667 109 39 ph ph ADJ eurjchem-1667 109 40 , , PUNCT eurjchem-1667 109 41 moisture moisture NOUN eurjchem-1667 109 42 , , PUNCT eurjchem-1667 109 43 flowability flowability NOUN eurjchem-1667 109 44 , , PUNCT eurjchem-1667 109 45 the the DET eurjchem-1667 109 46 angle angle NOUN eurjchem-1667 109 47 of of ADP eurjchem-1667 109 48 repose repose NOUN eurjchem-1667 109 49 , , PUNCT eurjchem-1667 109 50 and and CCONJ eurjchem-1667 109 51 particle particle NOUN eurjchem-1667 109 52 size size NOUN eurjchem-1667 109 53 ) ) PUNCT eurjchem-1667 109 54 . . PUNCT eurjchem-1667 110 1 wu wu PROPN eurjchem-1667 110 2 et et PROPN eurjchem-1667 110 3 al al PROPN eurjchem-1667 110 4 . . PUNCT eurjchem-1667 111 1 [ [ X eurjchem-1667 111 2 25 25 NUM eurjchem-1667 111 3 ] ] PUNCT eurjchem-1667 111 4 considered consider VERB eurjchem-1667 111 5 the the DET eurjchem-1667 111 6 feasibility feasibility NOUN eurjchem-1667 111 7 of of ADP eurjchem-1667 111 8 using use VERB eurjchem-1667 111 9 nir nir PROPN eurjchem-1667 111 10 spect‐ spect‐ PUNCT eurjchem-1667 111 11 roscopy roscopy VERB eurjchem-1667 111 12 as as ADP eurjchem-1667 111 13 a a DET eurjchem-1667 111 14 process process NOUN eurjchem-1667 111 15 analyzer analyzer NOUN eurjchem-1667 111 16 for for ADP eurjchem-1667 111 17 the the DET eurjchem-1667 111 18 non‐invasive non‐invasive ADJ eurjchem-1667 111 19 , , PUNCT eurjchem-1667 111 20 online online ADJ eurjchem-1667 111 21 and and CCONJ eurjchem-1667 111 22 real‐time real‐time NOUN eurjchem-1667 111 23 monitoring monitoring NOUN eurjchem-1667 111 24 of of ADP eurjchem-1667 111 25 extraction extraction NOUN eurjchem-1667 111 26 process process NOUN eurjchem-1667 111 27 for for ADP eurjchem-1667 111 28 traditional traditional ADJ eurjchem-1667 111 29 chinese chinese ADJ eurjchem-1667 111 30 medicine medicine NOUN eurjchem-1667 111 31 . . PUNCT eurjchem-1667 112 1 3 3 X eurjchem-1667 112 2 . . X eurjchem-1667 112 3 conclusion conclusion VERB eurjchem-1667 112 4 the the DET eurjchem-1667 112 5 quality quality NOUN eurjchem-1667 112 6 by by ADP eurjchem-1667 112 7 design design NOUN eurjchem-1667 112 8 for for ADP eurjchem-1667 112 9 pharmaceutical pharmaceutical NOUN eurjchem-1667 112 10 products product NOUN eurjchem-1667 112 11 and and CCONJ eurjchem-1667 112 12 processes process NOUN eurjchem-1667 112 13 is be AUX eurjchem-1667 112 14 a a DET eurjchem-1667 112 15 systematic systematic ADJ eurjchem-1667 112 16 , , PUNCT eurjchem-1667 112 17 scientific scientific ADJ eurjchem-1667 112 18 and and CCONJ eurjchem-1667 112 19 risk‐based risk‐base VERB eurjchem-1667 112 20 approach approach NOUN eurjchem-1667 112 21 to to ADP eurjchem-1667 112 22 the the DET eurjchem-1667 112 23 development development NOUN eurjchem-1667 112 24 of of ADP eurjchem-1667 112 25 every every DET eurjchem-1667 112 26 step step NOUN eurjchem-1667 112 27 involving involve VERB eurjchem-1667 112 28 in in ADP eurjchem-1667 112 29 the the DET eurjchem-1667 112 30 pharmaceutical pharmaceutical NOUN eurjchem-1667 112 31 manufacturing manufacturing NOUN eurjchem-1667 112 32 in in ADP eurjchem-1667 112 33 the the DET eurjchem-1667 112 34 direction direction NOUN eurjchem-1667 112 35 of of ADP eurjchem-1667 112 36 pre‐determined pre‐determine VERB eurjchem-1667 112 37 goals goal NOUN eurjchem-1667 112 38 . . PUNCT eurjchem-1667 113 1 this this DET eurjchem-1667 113 2 approach approach NOUN eurjchem-1667 113 3 controls control VERB eurjchem-1667 113 4 the the DET eurjchem-1667 113 5 quality quality NOUN eurjchem-1667 113 6 assurance assurance NOUN eurjchem-1667 113 7 of of ADP eurjchem-1667 113 8 the the DET eurjchem-1667 113 9 drug drug NOUN eurjchem-1667 113 10 , , PUNCT eurjchem-1667 113 11 which which PRON eurjchem-1667 113 12 is be AUX eurjchem-1667 113 13 the the DET eurjchem-1667 113 14 biggest big ADJ eurjchem-1667 113 15 output output NOUN eurjchem-1667 113 16 of of ADP eurjchem-1667 113 17 the the DET eurjchem-1667 113 18 pharmaceutical pharmaceutical ADJ eurjchem-1667 113 19 industry industry NOUN eurjchem-1667 113 20 that that PRON eurjchem-1667 113 21 has have VERB eurjchem-1667 113 22 human human ADJ eurjchem-1667 113 23 health health NOUN eurjchem-1667 113 24 in in ADP eurjchem-1667 113 25 the the DET eurjchem-1667 113 26 center center NOUN eurjchem-1667 113 27 . . PUNCT eurjchem-1667 114 1 the the DET eurjchem-1667 114 2 process process NOUN eurjchem-1667 114 3 analytical analytical ADJ eurjchem-1667 114 4 technology technology NOUN eurjchem-1667 114 5 that that PRON eurjchem-1667 114 6 the the DET eurjchem-1667 114 7 design design NOUN eurjchem-1667 114 8 and and CCONJ eurjchem-1667 114 9 the the DET eurjchem-1667 114 10 quality quality NOUN eurjchem-1667 114 11 used use VERB eurjchem-1667 114 12 together together ADV eurjchem-1667 114 13 with with ADP eurjchem-1667 114 14 analytical analytical ADJ eurjchem-1667 114 15 tools tool NOUN eurjchem-1667 114 16 is be AUX eurjchem-1667 114 17 a a DET eurjchem-1667 114 18 powerful powerful ADJ eurjchem-1667 114 19 quality quality NOUN eurjchem-1667 114 20 by by ADP eurjchem-1667 114 21 design design NOUN eurjchem-1667 114 22 used use VERB eurjchem-1667 114 23 for for ADP eurjchem-1667 114 24 designing design VERB eurjchem-1667 114 25 , , PUNCT eurjchem-1667 114 26 const‐ const‐ ADV eurjchem-1667 114 27 ructing ructe VERB eurjchem-1667 114 28 , , PUNCT eurjchem-1667 114 29 and and CCONJ eurjchem-1667 114 30 controlling control VERB eurjchem-1667 114 31 the the DET eurjchem-1667 114 32 quality quality NOUN eurjchem-1667 114 33 of of ADP eurjchem-1667 114 34 the the DET eurjchem-1667 114 35 product product NOUN eurjchem-1667 114 36 . . PUNCT eurjchem-1667 115 1 it it PRON eurjchem-1667 115 2 is be AUX eurjchem-1667 115 3 known know VERB eurjchem-1667 115 4 that that SCONJ eurjchem-1667 115 5 the the DET eurjchem-1667 115 6 number number NOUN eurjchem-1667 115 7 of of ADP eurjchem-1667 115 8 process process NOUN eurjchem-1667 115 9 analytical analytical ADJ eurjchem-1667 115 10 technology technology NOUN eurjchem-1667 115 11 applications application NOUN eurjchem-1667 115 12 in in ADP eurjchem-1667 115 13 the the DET eurjchem-1667 115 14 pharmaceutical pharmaceutical NOUN eurjchem-1667 115 15 industry industry NOUN eurjchem-1667 115 16 are be AUX eurjchem-1667 115 17 increasingly increasingly ADV eurjchem-1667 115 18 growing grow VERB eurjchem-1667 115 19 and and CCONJ eurjchem-1667 115 20 hence hence ADV eurjchem-1667 115 21 , , PUNCT eurjchem-1667 115 22 the the DET eurjchem-1667 115 23 number number NOUN eurjchem-1667 115 24 of of ADP eurjchem-1667 115 25 license license NOUN eurjchem-1667 115 26 applications application NOUN eurjchem-1667 115 27 used use VERB eurjchem-1667 115 28 this this DET eurjchem-1667 115 29 approach approach NOUN eurjchem-1667 115 30 is be AUX eurjchem-1667 115 31 rising rise VERB eurjchem-1667 115 32 rapidly rapidly ADV eurjchem-1667 115 33 . . PUNCT eurjchem-1667 116 1 the the DET eurjchem-1667 116 2 understanding understanding NOUN eurjchem-1667 116 3 and and CCONJ eurjchem-1667 116 4 implementing implement VERB eurjchem-1667 116 5 design design NOUN eurjchem-1667 116 6 and and CCONJ eurjchem-1667 116 7 quality quality NOUN eurjchem-1667 116 8 as as ADV eurjchem-1667 116 9 well well ADV eurjchem-1667 116 10 as as ADP eurjchem-1667 116 11 process process NOUN eurjchem-1667 116 12 analytical analytical ADJ eurjchem-1667 116 13 technology technology NOUN eurjchem-1667 116 14 practices practice NOUN eurjchem-1667 116 15 increase increase VERB eurjchem-1667 116 16 the the DET eurjchem-1667 116 17 quality quality NOUN eurjchem-1667 116 18 of of ADP eurjchem-1667 116 19 pharmaceutical pharmaceutical NOUN eurjchem-1667 116 20 products product NOUN eurjchem-1667 116 21 , , PUNCT eurjchem-1667 116 22 reduce reduce VERB eurjchem-1667 116 23 costs cost NOUN eurjchem-1667 116 24 over over ADP eurjchem-1667 116 25 the the DET eurjchem-1667 116 26 long long ADJ eurjchem-1667 116 27 term term NOUN eurjchem-1667 116 28 , , PUNCT eurjchem-1667 116 29 and and CCONJ eurjchem-1667 116 30 modernize modernize VERB eurjchem-1667 116 31 the the DET eurjchem-1667 116 32 supervision supervision NOUN eurjchem-1667 116 33 of of ADP eurjchem-1667 116 34 the the DET eurjchem-1667 116 35 pharmaceutical pharmaceutical ADJ eurjchem-1667 116 36 industry industry NOUN eurjchem-1667 116 37 . . PUNCT eurjchem-1667 117 1 the the DET eurjchem-1667 117 2 continuity continuity NOUN eurjchem-1667 117 3 of of ADP eurjchem-1667 117 4 drug drug NOUN eurjchem-1667 117 5 quality quality NOUN eurjchem-1667 117 6 is be AUX eurjchem-1667 117 7 indispensable indispensable ADJ eurjchem-1667 117 8 for for ADP eurjchem-1667 117 9 manufacturers manufacturer NOUN eurjchem-1667 117 10 , , PUNCT eurjchem-1667 117 11 supervisory supervisory ADJ eurjchem-1667 117 12 agencies agency NOUN eurjchem-1667 117 13 and and CCONJ eurjchem-1667 117 14 patients patient NOUN eurjchem-1667 117 15 , , PUNCT eurjchem-1667 117 16 which which PRON eurjchem-1667 117 17 makes make VERB eurjchem-1667 117 18 these these DET eurjchem-1667 117 19 studies study NOUN eurjchem-1667 117 20 one one NUM eurjchem-1667 117 21 of of ADP eurjchem-1667 117 22 the the DET eurjchem-1667 117 23 priorities priority NOUN eurjchem-1667 117 24 in in ADP eurjchem-1667 117 25 the the DET eurjchem-1667 117 26 field field NOUN eurjchem-1667 117 27 and and CCONJ eurjchem-1667 117 28 , , PUNCT eurjchem-1667 117 29 requires require VERB eurjchem-1667 117 30 further further ADJ eurjchem-1667 117 31 research research NOUN eurjchem-1667 117 32 . . PUNCT eurjchem-1667 118 1 references reference NOUN eurjchem-1667 118 2 [ [ X eurjchem-1667 118 3 1 1 NUM eurjchem-1667 118 4 ] ] PUNCT eurjchem-1667 118 5 . . PUNCT eurjchem-1667 119 1 mike mike PROPN eurjchem-1667 119 2 , , PUNCT eurjchem-1667 119 3 f. f. PROPN eurjchem-1667 119 4 ; ; PUNCT eurjchem-1667 119 5 bozdag bozdag PROPN eurjchem-1667 119 6 , , PUNCT eurjchem-1667 119 7 p. p. PROPN eurjchem-1667 119 8 s. s. PROPN eurjchem-1667 119 9 ; ; PUNCT eurjchem-1667 119 10 oner oner NOUN eurjchem-1667 119 11 , , PUNCT eurjchem-1667 119 12 l. l. PROPN eurjchem-1667 119 13 hacettepe hacettepe PROPN eurjchem-1667 119 14 univ univ PROPN eurjchem-1667 119 15 . . PUNCT eurjchem-1667 120 1 j. j. PROPN eurjchem-1667 120 2 fac fac PROPN eurjchem-1667 120 3 . . PUNCT eurjchem-1667 120 4 pharm pharm PROPN eurjchem-1667 120 5 . . PUNCT eurjchem-1667 121 1 2013 2013 NUM eurjchem-1667 121 2 , , PUNCT eurjchem-1667 121 3 33(2 33(2 NUM eurjchem-1667 121 4 ) ) PUNCT eurjchem-1667 121 5 , , PUNCT eurjchem-1667 121 6 203‐230 203‐230 NUM eurjchem-1667 121 7 . . PUNCT eurjchem-1667 122 1 [ [ X eurjchem-1667 122 2 2 2 NUM eurjchem-1667 122 3 ] ] PUNCT eurjchem-1667 122 4 . . PUNCT eurjchem-1667 123 1 turkey turkey PROPN eurjchem-1667 123 2 pharmaceutical pharmaceutical PROPN eurjchem-1667 123 3 sector sector NOUN eurjchem-1667 123 4 vision vision NOUN eurjchem-1667 123 5 2023 2023 NUM eurjchem-1667 123 6 report report NOUN eurjchem-1667 123 7 strategy strategy NOUN eurjchem-1667 123 8 document document NOUN eurjchem-1667 123 9 , , PUNCT eurjchem-1667 123 10 association association NOUN eurjchem-1667 123 11 of of ADP eurjchem-1667 123 12 research‐based research‐base VERB eurjchem-1667 123 13 pharmaceutical pharmaceutical ADJ eurjchem-1667 123 14 companies company NOUN eurjchem-1667 123 15 . . PUNCT eurjchem-1667 124 1 2012 2012 NUM eurjchem-1667 124 2 , , PUNCT eurjchem-1667 124 3 pp pp ADJ eurjchem-1667 124 4 . . PUNCT eurjchem-1667 124 5 23‐27 23‐27 NUM eurjchem-1667 124 6 . . PUNCT eurjchem-1667 125 1 [ [ X eurjchem-1667 125 2 3 3 NUM eurjchem-1667 125 3 ] ] PUNCT eurjchem-1667 125 4 . . PUNCT eurjchem-1667 126 1 dematas demata NOUN eurjchem-1667 126 2 , , PUNCT eurjchem-1667 126 3 m. m. NOUN eurjchem-1667 126 4 ; ; PUNCT eurjchem-1667 126 5 debeer debeer NOUN eurjchem-1667 126 6 , , PUNCT eurjchem-1667 126 7 t. t. PROPN eurjchem-1667 126 8 ; ; PUNCT eurjchem-1667 126 9 folestad folestad PROPN eurjchem-1667 126 10 , , PUNCT eurjchem-1667 126 11 s. s. PROPN eurjchem-1667 126 12 ; ; PUNCT eurjchem-1667 126 13 ketolainen ketolainen NOUN eurjchem-1667 126 14 , , PUNCT eurjchem-1667 126 15 j. j. PROPN eurjchem-1667 126 16 ; ; PUNCT eurjchem-1667 126 17 linden linden PROPN eurjchem-1667 126 18 , , PUNCT eurjchem-1667 126 19 h. h. PROPN eurjchem-1667 126 20 ; ; PUNCT eurjchem-1667 126 21 lopes lopes PROPN eurjchem-1667 126 22 , , PUNCT eurjchem-1667 126 23 j. j. PROPN eurjchem-1667 126 24 a. a. PROPN eurjchem-1667 126 25 ; ; PUNCT eurjchem-1667 126 26 oostra oostra PROPN eurjchem-1667 126 27 , , PUNCT eurjchem-1667 126 28 w. w. PROPN eurjchem-1667 126 29 ; ; PUNCT eurjchem-1667 126 30 weimer weimer PROPN eurjchem-1667 126 31 , , PUNCT eurjchem-1667 126 32 m. m. NOUN eurjchem-1667 126 33 ; ; PUNCT eurjchem-1667 126 34 ohrngren ohrngren NOUN eurjchem-1667 126 35 , , PUNCT eurjchem-1667 126 36 p. p. NOUN eurjchem-1667 126 37 ; ; PUNCT eurjchem-1667 126 38 rantanen rantanen NOUN eurjchem-1667 126 39 , , PUNCT eurjchem-1667 126 40 j. j. PROPN eurjchem-1667 126 41 eur eur PROPN eurjchem-1667 126 42 . . PUNCT eurjchem-1667 127 1 j. j. PROPN eurjchem-1667 127 2 pharm pharm PROPN eurjchem-1667 127 3 . . PUNCT eurjchem-1667 128 1 sci sci PROPN eurjchem-1667 128 2 . . PROPN eurjchem-1667 128 3 2016 2016 NUM eurjchem-1667 128 4 , , PUNCT eurjchem-1667 128 5 90 90 NUM eurjchem-1667 128 6 , , PUNCT eurjchem-1667 128 7 2‐7 2‐7 NUM eurjchem-1667 128 8 . . PUNCT eurjchem-1667 129 1 [ [ X eurjchem-1667 129 2 4 4 NUM eurjchem-1667 129 3 ] ] PUNCT eurjchem-1667 129 4 . . PUNCT eurjchem-1667 130 1 raman raman NOUN eurjchem-1667 130 2 , , PUNCT eurjchem-1667 130 3 n. n. PROPN eurjchem-1667 130 4 v. v. PROPN eurjchem-1667 130 5 v. v. PROPN eurjchem-1667 130 6 s. s. PROPN eurjchem-1667 130 7 s. s. PROPN eurjchem-1667 130 8 ; ; PUNCT eurjchem-1667 130 9 mallu mallu PROPN eurjchem-1667 130 10 , , PUNCT eurjchem-1667 130 11 u. u. PROPN eurjchem-1667 130 12 r. r. PROPN eurjchem-1667 130 13 ; ; PUNCT eurjchem-1667 130 14 bapatu bapatu NOUN eurjchem-1667 130 15 , , PUNCT eurjchem-1667 130 16 h. h. PROPN eurjchem-1667 130 17 r. r. PROPN eurjchem-1667 130 18 j. j. PROPN eurjchem-1667 130 19 chem chem PROPN eurjchem-1667 130 20 . . PUNCT eurjchem-1667 131 1 2015 2015 NUM eurjchem-1667 131 2 , , PUNCT eurjchem-1667 131 3 2015 2015 NUM eurjchem-1667 131 4 , , PUNCT eurjchem-1667 131 5 1‐ 1‐ NUM eurjchem-1667 131 6 8 8 NUM eurjchem-1667 131 7 , , PUNCT eurjchem-1667 131 8 i i PROPN eurjchem-1667 131 9 d d PROPN eurjchem-1667 131 10 : : PUNCT eurjchem-1667 131 11 435129 435129 NUM eurjchem-1667 131 12 . . PUNCT eurjchem-1667 132 1 [ [ X eurjchem-1667 132 2 5 5 NUM eurjchem-1667 132 3 ] ] PUNCT eurjchem-1667 132 4 . . PUNCT eurjchem-1667 133 1 politis politis PROPN eurjchem-1667 133 2 , , PUNCT eurjchem-1667 133 3 s. s. PROPN eurjchem-1667 133 4 n. n. PROPN eurjchem-1667 133 5 ; ; PUNCT eurjchem-1667 133 6 colombo colombo NOUN eurjchem-1667 133 7 , , PUNCT eurjchem-1667 133 8 p. p. NOUN eurjchem-1667 133 9 ; ; PUNCT eurjchem-1667 133 10 colombo colombo NOUN eurjchem-1667 133 11 , , PUNCT eurjchem-1667 133 12 g. g. PROPN eurjchem-1667 133 13 ; ; PUNCT eurjchem-1667 133 14 rekkas rekkas PROPN eurjchem-1667 133 15 , , PUNCT eurjchem-1667 133 16 d. d. PROPN eurjchem-1667 133 17 m. m. PROPN eurjchem-1667 133 18 drug drug PROPN eurjchem-1667 133 19 dev dev PROPN eurjchem-1667 133 20 . . PUNCT eurjchem-1667 134 1 ind ind PROPN eurjchem-1667 134 2 . . PUNCT eurjchem-1667 135 1 pharm pharm PROPN eurjchem-1667 135 2 . . PUNCT eurjchem-1667 136 1 2017 2017 NUM eurjchem-1667 136 2 , , PUNCT eurjchem-1667 136 3 43(6 43(6 NOUN eurjchem-1667 136 4 ) ) PUNCT eurjchem-1667 136 5 , , PUNCT eurjchem-1667 136 6 889‐901 889‐901 NOUN eurjchem-1667 136 7 . . PUNCT eurjchem-1667 137 1 [ [ X eurjchem-1667 137 2 6 6 NUM eurjchem-1667 137 3 ] ] PUNCT eurjchem-1667 137 4 . . PUNCT eurjchem-1667 137 5 rantanen rantanen PROPN eurjchem-1667 137 6 , , PUNCT eurjchem-1667 137 7 j. j. PROPN eurjchem-1667 137 8 ; ; PUNCT eurjchem-1667 137 9 khinast khinast PROPN eurjchem-1667 137 10 , , PUNCT eurjchem-1667 137 11 j. j. PROPN eurjchem-1667 137 12 j. j. PROPN eurjchem-1667 137 13 pharm pharm PROPN eurjchem-1667 137 14 . . PUNCT eurjchem-1667 138 1 sci sci PROPN eurjchem-1667 138 2 . . PROPN eurjchem-1667 138 3 2015 2015 NUM eurjchem-1667 138 4 , , PUNCT eurjchem-1667 138 5 104(11 104(11 NUM eurjchem-1667 138 6 ) ) PUNCT eurjchem-1667 138 7 , , PUNCT eurjchem-1667 138 8 3612‐3638 3612‐3638 NOUN eurjchem-1667 138 9 . . PUNCT eurjchem-1667 139 1 [ [ X eurjchem-1667 139 2 7 7 NUM eurjchem-1667 139 3 ] ] PUNCT eurjchem-1667 139 4 . . PUNCT eurjchem-1667 139 5 burggraeve burggraeve PROPN eurjchem-1667 139 6 , , PUNCT eurjchem-1667 139 7 a. a. NOUN eurjchem-1667 139 8 ; ; PUNCT eurjchem-1667 139 9 monteyne monteyne NOUN eurjchem-1667 139 10 , , PUNCT eurjchem-1667 139 11 t. t. PROPN eurjchem-1667 139 12 ; ; PUNCT eurjchem-1667 139 13 vervaet vervaet NOUN eurjchem-1667 139 14 , , PUNCT eurjchem-1667 139 15 c. c. PROPN eurjchem-1667 139 16 ; ; PUNCT eurjchem-1667 139 17 remon remon PROPN eurjchem-1667 139 18 , , PUNCT eurjchem-1667 139 19 j. j. PROPN eurjchem-1667 139 20 p. p. PROPN eurjchem-1667 139 21 ; ; PUNCT eurjchem-1667 139 22 beer beer NOUN eurjchem-1667 139 23 , , PUNCT eurjchem-1667 139 24 t. t. PROPN eurjchem-1667 139 25 eur eur PROPN eurjchem-1667 139 26 . . PUNCT eurjchem-1667 140 1 j. j. PROPN eurjchem-1667 140 2 pharm pharm PROPN eurjchem-1667 140 3 . . PUNCT eurjchem-1667 141 1 biopharm biopharm PROPN eurjchem-1667 141 2 . . PUNCT eurjchem-1667 142 1 2013 2013 NUM eurjchem-1667 142 2 , , PUNCT eurjchem-1667 142 3 83(1 83(1 PROPN eurjchem-1667 142 4 ) ) PUNCT eurjchem-1667 142 5 , , PUNCT eurjchem-1667 142 6 2‐15 2‐15 NUM eurjchem-1667 142 7 . . PUNCT eurjchem-1667 143 1 [ [ X eurjchem-1667 143 2 8 8 NUM eurjchem-1667 143 3 ] ] PUNCT eurjchem-1667 143 4 . . PUNCT eurjchem-1667 144 1 ferreira ferreira PROPN eurjchem-1667 144 2 , , PUNCT eurjchem-1667 144 3 a. a. NOUN eurjchem-1667 144 4 p. p. NOUN eurjchem-1667 144 5 ; ; PUNCT eurjchem-1667 144 6 tobyn tobyn PROPN eurjchem-1667 144 7 , , PUNCT eurjchem-1667 144 8 m. m. NOUN eurjchem-1667 144 9 pharm pharm PROPN eurjchem-1667 144 10 . . PUNCT eurjchem-1667 145 1 dev dev AUX eurjchem-1667 145 2 . . PUNCT eurjchem-1667 145 3 technol technol PROPN eurjchem-1667 145 4 . . PROPN eurjchem-1667 145 5 2015 2015 NUM eurjchem-1667 145 6 , , PUNCT eurjchem-1667 145 7 20(5 20(5 NUM eurjchem-1667 145 8 ) ) PUNCT eurjchem-1667 145 9 , , PUNCT eurjchem-1667 145 10 513‐527 513‐527 NUM eurjchem-1667 145 11 . . PUNCT eurjchem-1667 146 1 [ [ X eurjchem-1667 146 2 9 9 NUM eurjchem-1667 146 3 ] ] PUNCT eurjchem-1667 146 4 . . PUNCT eurjchem-1667 147 1 pramod pramod PROPN eurjchem-1667 147 2 , , PUNCT eurjchem-1667 147 3 k. k. PROPN eurjchem-1667 147 4 ; ; PUNCT eurjchem-1667 147 5 tahir tahir PROPN eurjchem-1667 147 6 , , PUNCT eurjchem-1667 147 7 m. m. NOUN eurjchem-1667 147 8 a. a. PROPN eurjchem-1667 147 9 ; ; PUNCT eurjchem-1667 147 10 charoo charoo PROPN eurjchem-1667 147 11 , , PUNCT eurjchem-1667 147 12 n. n. NOUN eurjchem-1667 147 13 ; ; PUNCT eurjchem-1667 147 14 ansari ansari PROPN eurjchem-1667 147 15 , , PUNCT eurjchem-1667 147 16 s. s. PROPN eurjchem-1667 147 17 ; ; PUNCT eurjchem-1667 147 18 ali ali PROPN eurjchem-1667 147 19 , , PUNCT eurjchem-1667 147 20 h. h. PROPN eurjchem-1667 147 21 int int PROPN eurjchem-1667 147 22 . . PUNCT eurjchem-1667 148 1 j. j. PROPN eurjchem-1667 148 2 pharm pharm PROPN eurjchem-1667 148 3 . . PUNCT eurjchem-1667 148 4 investig investig PROPN eurjchem-1667 148 5 . . PROPN eurjchem-1667 148 6 2016 2016 NUM eurjchem-1667 148 7 , , PUNCT eurjchem-1667 148 8 6(3 6(3 NUM eurjchem-1667 148 9 ) ) PUNCT eurjchem-1667 148 10 , , PUNCT eurjchem-1667 148 11 129‐138 129‐138 NUM eurjchem-1667 148 12 . . PUNCT eurjchem-1667 149 1 [ [ X eurjchem-1667 149 2 10 10 NUM eurjchem-1667 149 3 ] ] PUNCT eurjchem-1667 149 4 . . PUNCT eurjchem-1667 150 1 rathore rathore PROPN eurjchem-1667 150 2 , , PUNCT eurjchem-1667 150 3 a. a. PROPN eurjchem-1667 150 4 s. s. PROPN eurjchem-1667 150 5 ; ; PUNCT eurjchem-1667 150 6 bhambure bhambure PROPN eurjchem-1667 150 7 , , PUNCT eurjchem-1667 150 8 r. r. PROPN eurjchem-1667 150 9 ; ; PUNCT eurjchem-1667 150 10 ghare ghare PROPN eurjchem-1667 150 11 , , PUNCT eurjchem-1667 150 12 v. v. PROPN eurjchem-1667 150 13 anal anal ADJ eurjchem-1667 150 14 . . PUNCT eurjchem-1667 151 1 bioanal bioanal ADJ eurjchem-1667 151 2 . . PUNCT eurjchem-1667 151 3 chem chem NOUN eurjchem-1667 151 4 . . PUNCT eurjchem-1667 152 1 2010 2010 NUM eurjchem-1667 152 2 , , PUNCT eurjchem-1667 152 3 398(1 398(1 NUM eurjchem-1667 152 4 ) ) PUNCT eurjchem-1667 152 5 , , PUNCT eurjchem-1667 152 6 137‐154 137‐154 NUM eurjchem-1667 152 7 . . PUNCT eurjchem-1667 153 1 [ [ X eurjchem-1667 153 2 11 11 NUM eurjchem-1667 153 3 ] ] PUNCT eurjchem-1667 153 4 . . PUNCT eurjchem-1667 154 1 haleem haleem PROPN eurjchem-1667 154 2 , , PUNCT eurjchem-1667 154 3 r. r. PROPN eurjchem-1667 154 4 m. m. PROPN eurjchem-1667 154 5 ; ; PUNCT eurjchem-1667 154 6 salem salem NOUN eurjchem-1667 154 7 , , PUNCT eurjchem-1667 154 8 m. m. NOUN eurjchem-1667 154 9 y. y. PROPN eurjchem-1667 154 10 ; ; PUNCT eurjchem-1667 154 11 fatahallah fatahallah PROPN eurjchem-1667 154 12 , , PUNCT eurjchem-1667 154 13 f. f. PROPN eurjchem-1667 154 14 a. a. PROPN eurjchem-1667 154 15 ; ; PUNCT eurjchem-1667 154 16 abdelfattah abdelfattah PROPN eurjchem-1667 154 17 , , PUNCT eurjchem-1667 154 18 l. l. PROPN eurjchem-1667 154 19 e. e. PROPN eurjchem-1667 154 20 saudi saudi PROPN eurjchem-1667 154 21 pharm pharm PROPN eurjchem-1667 154 22 . . PUNCT eurjchem-1667 155 1 j. j. PROPN eurjchem-1667 155 2 2015 2015 NUM eurjchem-1667 155 3 , , PUNCT eurjchem-1667 155 4 23(5 23(5 NUM eurjchem-1667 155 5 ) ) PUNCT eurjchem-1667 155 6 , , PUNCT eurjchem-1667 155 7 463‐469 463‐469 NUM eurjchem-1667 155 8 . . PUNCT eurjchem-1667 156 1 [ [ X eurjchem-1667 156 2 12 12 NUM eurjchem-1667 156 3 ] ] PUNCT eurjchem-1667 156 4 . . PUNCT eurjchem-1667 157 1 aksu aksu PROPN eurjchem-1667 157 2 , , PUNCT eurjchem-1667 157 3 b. b. PROPN eurjchem-1667 157 4 ; ; PUNCT eurjchem-1667 157 5 beer beer NOUN eurjchem-1667 157 6 , , PUNCT eurjchem-1667 157 7 t. t. PROPN eurjchem-1667 157 8 ; ; PUNCT eurjchem-1667 157 9 folestad folestad PROPN eurjchem-1667 157 10 , , PUNCT eurjchem-1667 157 11 s. s. PROPN eurjchem-1667 157 12 ; ; PUNCT eurjchem-1667 157 13 ketolainen ketolainen NOUN eurjchem-1667 157 14 , , PUNCT eurjchem-1667 157 15 j. j. PROPN eurjchem-1667 157 16 ; ; PUNCT eurjchem-1667 157 17 linden linden PROPN eurjchem-1667 157 18 , , PUNCT eurjchem-1667 157 19 h. h. PROPN eurjchem-1667 157 20 ; ; PUNCT eurjchem-1667 157 21 lopes lopes PROPN eurjchem-1667 157 22 , , PUNCT eurjchem-1667 157 23 j. j. PROPN eurjchem-1667 157 24 a. a. PROPN eurjchem-1667 157 25 ; ; PUNCT eurjchem-1667 157 26 matas mata NOUN eurjchem-1667 157 27 , , PUNCT eurjchem-1667 157 28 m. m. NOUN eurjchem-1667 157 29 ; ; PUNCT eurjchem-1667 157 30 oostra oostra PROPN eurjchem-1667 157 31 , , PUNCT eurjchem-1667 157 32 w. w. PROPN eurjchem-1667 157 33 ; ; PUNCT eurjchem-1667 157 34 rantanen rantanen PROPN eurjchem-1667 157 35 , , PUNCT eurjchem-1667 157 36 j. j. PROPN eurjchem-1667 157 37 ; ; PUNCT eurjchem-1667 157 38 weimer weimer PROPN eurjchem-1667 157 39 , , PUNCT eurjchem-1667 157 40 m. m. NOUN eurjchem-1667 157 41 eur eur PROPN eurjchem-1667 157 42 . . PUNCT eurjchem-1667 158 1 j. j. PROPN eurjchem-1667 158 2 pharm pharm PROPN eurjchem-1667 158 3 . . PUNCT eurjchem-1667 159 1 sci sci PROPN eurjchem-1667 159 2 . . PROPN eurjchem-1667 159 3 2012 2012 NUM eurjchem-1667 159 4 , , PUNCT eurjchem-1667 159 5 47(2 47(2 PROPN eurjchem-1667 159 6 ) ) PUNCT eurjchem-1667 159 7 , , PUNCT eurjchem-1667 159 8 402‐405 402‐405 PROPN eurjchem-1667 159 9 . . PUNCT eurjchem-1667 160 1 [ [ X eurjchem-1667 160 2 13 13 NUM eurjchem-1667 160 3 ] ] PUNCT eurjchem-1667 160 4 . . PUNCT eurjchem-1667 160 5 fda fda PROPN eurjchem-1667 160 6 , , PUNCT eurjchem-1667 160 7 guidance guidance NOUN eurjchem-1667 160 8 for for ADP eurjchem-1667 160 9 industry industry NOUN eurjchem-1667 160 10 pat pat NOUN eurjchem-1667 160 11 ‐ ‐ VERB eurjchem-1667 160 12 a a DET eurjchem-1667 160 13 framework framework NOUN eurjchem-1667 160 14 for for ADP eurjchem-1667 160 15 innovative innovative ADJ eurjchem-1667 160 16 pharmaceutical pharmaceutical ADJ eurjchem-1667 160 17 development development NOUN eurjchem-1667 160 18 , , PUNCT eurjchem-1667 160 19 manufacturing manufacturing NOUN eurjchem-1667 160 20 , , PUNCT eurjchem-1667 160 21 and and CCONJ eurjchem-1667 160 22 quality quality NOUN eurjchem-1667 160 23 assurance assurance NOUN eurjchem-1667 160 24 , , PUNCT eurjchem-1667 160 25 2004 2004 NUM eurjchem-1667 160 26 . . PUNCT eurjchem-1667 161 1 [ [ X eurjchem-1667 161 2 14 14 NUM eurjchem-1667 161 3 ] ] SYM eurjchem-1667 161 4 . . PUNCT eurjchem-1667 162 1 zhang zhang PROPN eurjchem-1667 162 2 , , PUNCT eurjchem-1667 162 3 l. l. PROPN eurjchem-1667 162 4 ; ; PUNCT eurjchem-1667 162 5 mao mao PROPN eurjchem-1667 162 6 , , PUNCT eurjchem-1667 162 7 s. s. PROPN eurjchem-1667 162 8 asian asian PROPN eurjchem-1667 162 9 j. j. PROPN eurjchem-1667 162 10 pharm pharm PROPN eurjchem-1667 162 11 . . PUNCT eurjchem-1667 163 1 sci sci PROPN eurjchem-1667 163 2 . . PUNCT eurjchem-1667 164 1 ( ( PUNCT eurjchem-1667 164 2 ajps ajps ADJ eurjchem-1667 164 3 ) ) PUNCT eurjchem-1667 164 4 2017 2017 NUM eurjchem-1667 164 5 , , PUNCT eurjchem-1667 164 6 12(1 12(1 NUM eurjchem-1667 164 7 ) ) PUNCT eurjchem-1667 164 8 , , PUNCT eurjchem-1667 164 9 1‐8 1‐8 NOUN eurjchem-1667 164 10 . . PUNCT eurjchem-1667 165 1 [ [ X eurjchem-1667 165 2 15 15 NUM eurjchem-1667 165 3 ] ] PUNCT eurjchem-1667 165 4 . . PUNCT eurjchem-1667 166 1 peres peres PROPN eurjchem-1667 166 2 , , PUNCT eurjchem-1667 166 3 d. d. PROPN eurjchem-1667 166 4 d. d. PROPN eurjchem-1667 166 5 ; ; PUNCT eurjchem-1667 166 6 ariede ariede PROPN eurjchem-1667 166 7 , , PUNCT eurjchem-1667 166 8 m. m. PROPN eurjchem-1667 166 9 b. b. PROPN eurjchem-1667 166 10 ; ; PUNCT eurjchem-1667 166 11 candido candido PROPN eurjchem-1667 166 12 , , PUNCT eurjchem-1667 166 13 t. t. PROPN eurjchem-1667 166 14 m. m. NOUN eurjchem-1667 166 15 ; ; PUNCT eurjchem-1667 166 16 almeida almeida PROPN eurjchem-1667 166 17 , , PUNCT eurjchem-1667 166 18 t. t. PROPN eurjchem-1667 166 19 s. s. PROPN eurjchem-1667 166 20 ; ; PUNCT eurjchem-1667 166 21 lourenco lourenco PROPN eurjchem-1667 166 22 , , PUNCT eurjchem-1667 166 23 f. f. PROPN eurjchem-1667 166 24 r. r. PROPN eurjchem-1667 166 25 ; ; PUNCT eurjchem-1667 166 26 consiglieri consiglieri PROPN eurjchem-1667 166 27 , , PUNCT eurjchem-1667 166 28 v. v. PROPN eurjchem-1667 166 29 o. o. PROPN eurjchem-1667 166 30 ; ; PUNCT eurjchem-1667 166 31 kaneko kaneko PROPN eurjchem-1667 166 32 , , PUNCT eurjchem-1667 166 33 t. t. NOUN eurjchem-1667 166 34 m. m. NOUN eurjchem-1667 166 35 ; ; PUNCT eurjchem-1667 166 36 velasco velasco PROPN eurjchem-1667 166 37 , , PUNCT eurjchem-1667 166 38 m. m. NOUN eurjchem-1667 166 39 v. v. PROPN eurjchem-1667 166 40 r. r. PROPN eurjchem-1667 166 41 ; ; PUNCT eurjchem-1667 166 42 baby baby NOUN eurjchem-1667 166 43 , , PUNCT eurjchem-1667 166 44 a. a. PROPN eurjchem-1667 166 45 r. r. PROPN eurjchem-1667 166 46 drug drug PROPN eurjchem-1667 166 47 dev dev PROPN eurjchem-1667 166 48 . . PUNCT eurjchem-1667 167 1 ind ind PROPN eurjchem-1667 167 2 . . PUNCT eurjchem-1667 168 1 pharm pharm PROPN eurjchem-1667 168 2 . . PUNCT eurjchem-1667 169 1 2017 2017 NUM eurjchem-1667 169 2 , , PUNCT eurjchem-1667 169 3 43(2 43(2 NUM eurjchem-1667 169 4 ) ) PUNCT eurjchem-1667 169 5 , , PUNCT eurjchem-1667 169 6 246‐256 246‐256 NUM eurjchem-1667 169 7 . . PUNCT eurjchem-1667 170 1 [ [ X eurjchem-1667 170 2 16 16 NUM eurjchem-1667 170 3 ] ] PUNCT eurjchem-1667 170 4 . . PUNCT eurjchem-1667 171 1 naidu naidu PROPN eurjchem-1667 171 2 , , PUNCT eurjchem-1667 171 3 v. v. PROPN eurjchem-1667 171 4 r. r. PROPN eurjchem-1667 171 5 ; ; PUNCT eurjchem-1667 171 6 deshpande deshpande PROPN eurjchem-1667 171 7 , , PUNCT eurjchem-1667 171 8 r. r. PROPN eurjchem-1667 171 9 s. s. PROPN eurjchem-1667 171 10 ; ; PUNCT eurjchem-1667 171 11 syed sye VERB eurjchem-1667 171 12 , , PUNCT eurjchem-1667 171 13 m. m. NOUN eurjchem-1667 171 14 r. r. PROPN eurjchem-1667 171 15 ; ; PUNCT eurjchem-1667 171 16 deoghare deoghare NOUN eurjchem-1667 171 17 , , PUNCT eurjchem-1667 171 18 p. p. NOUN eurjchem-1667 171 19 ; ; PUNCT eurjchem-1667 171 20 singh singh PROPN eurjchem-1667 171 21 , , PUNCT eurjchem-1667 171 22 d. d. PROPN eurjchem-1667 171 23 ; ; PUNCT eurjchem-1667 171 24 wakte wakte PROPN eurjchem-1667 171 25 , , PUNCT eurjchem-1667 171 26 p. p. NOUN eurjchem-1667 171 27 s. s. PROPN eurjchem-1667 172 1 aaps aaps PROPN eurjchem-1667 172 2 pharm pharm PROPN eurjchem-1667 172 3 . . PUNCT eurjchem-1667 173 1 sci sci PROPN eurjchem-1667 173 2 . . PUNCT eurjchem-1667 173 3 tech tech PROPN eurjchem-1667 173 4 . . PUNCT eurjchem-1667 174 1 2017 2017 NUM eurjchem-1667 174 2 , , PUNCT eurjchem-1667 174 3 18(6 18(6 NOUN eurjchem-1667 174 4 ) ) PUNCT eurjchem-1667 174 5 , , PUNCT eurjchem-1667 174 6 2045‐2054 2045‐2054 NUM eurjchem-1667 174 7 . . PUNCT eurjchem-1667 175 1 [ [ X eurjchem-1667 175 2 17 17 NUM eurjchem-1667 175 3 ] ] PUNCT eurjchem-1667 175 4 . . PUNCT eurjchem-1667 176 1 hertrampf hertrampf NOUN eurjchem-1667 176 2 , , PUNCT eurjchem-1667 176 3 a. a. NOUN eurjchem-1667 176 4 ; ; PUNCT eurjchem-1667 176 5 muller muller PROPN eurjchem-1667 176 6 , , PUNCT eurjchem-1667 176 7 h. h. PROPN eurjchem-1667 176 8 ; ; PUNCT eurjchem-1667 176 9 menezes menezes PROPN eurjchem-1667 176 10 , , PUNCT eurjchem-1667 176 11 j. j. PROPN eurjchem-1667 176 12 c. c. PROPN eurjchem-1667 176 13 ; ; PUNCT eurjchem-1667 176 14 herdling herdle VERB eurjchem-1667 176 15 , , PUNCT eurjchem-1667 176 16 t. t. PROPN eurjchem-1667 176 17 j. j. PROPN eurjchem-1667 176 18 pharm pharm PROPN eurjchem-1667 176 19 . . PUNCT eurjchem-1667 176 20 biomed biome VERB eurjchem-1667 176 21 . . PUNCT eurjchem-1667 177 1 anal anal ADJ eurjchem-1667 177 2 . . PUNCT eurjchem-1667 178 1 2015 2015 NUM eurjchem-1667 178 2 , , PUNCT eurjchem-1667 178 3 114 114 NUM eurjchem-1667 178 4 , , PUNCT eurjchem-1667 178 5 208‐215 208‐215 NUM eurjchem-1667 178 6 . . PUNCT eurjchem-1667 179 1 [ [ X eurjchem-1667 179 2 18 18 NUM eurjchem-1667 179 3 ] ] SYM eurjchem-1667 179 4 . . PUNCT eurjchem-1667 180 1 chavez chavez PROPN eurjchem-1667 180 2 , , PUNCT eurjchem-1667 180 3 p. p. PROPN eurjchem-1667 180 4 f. f. PROPN eurjchem-1667 180 5 ; ; PUNCT eurjchem-1667 180 6 lebrun lebrun NOUN eurjchem-1667 180 7 , , PUNCT eurjchem-1667 180 8 p. p. NOUN eurjchem-1667 180 9 ; ; PUNCT eurjchem-1667 180 10 sacre sacre PROPN eurjchem-1667 180 11 , , PUNCT eurjchem-1667 180 12 p. p. PROPN eurjchem-1667 180 13 y. y. PROPN eurjchem-1667 180 14 ; ; PUNCT eurjchem-1667 180 15 bleye bleye NOUN eurjchem-1667 180 16 , , PUNCT eurjchem-1667 180 17 c. c. NOUN eurjchem-1667 180 18 ; ; PUNCT eurjchem-1667 180 19 netchacovitch netchacovitch PROPN eurjchem-1667 180 20 , , PUNCT eurjchem-1667 180 21 l. l. PROPN eurjchem-1667 180 22 ; ; PUNCT eurjchem-1667 180 23 cuypers cuyper NOUN eurjchem-1667 180 24 , , PUNCT eurjchem-1667 180 25 s. s. PROPN eurjchem-1667 180 26 ; ; PUNCT eurjchem-1667 180 27 mantanus mantanus PROPN eurjchem-1667 180 28 , , PUNCT eurjchem-1667 180 29 j. j. PROPN eurjchem-1667 180 30 ; ; PUNCT eurjchem-1667 180 31 motte motte PROPN eurjchem-1667 180 32 , , PUNCT eurjchem-1667 180 33 h. h. PROPN eurjchem-1667 180 34 ; ; PUNCT eurjchem-1667 180 35 schubert schubert PROPN eurjchem-1667 180 36 , , PUNCT eurjchem-1667 180 37 m. m. NOUN eurjchem-1667 180 38 ; ; PUNCT eurjchem-1667 180 39 evrard evrard PROPN eurjchem-1667 180 40 , , PUNCT eurjchem-1667 180 41 b. b. PROPN eurjchem-1667 180 42 ; ; PUNCT eurjchem-1667 180 43 hubert hubert PROPN eurjchem-1667 180 44 , , PUNCT eurjchem-1667 180 45 p. p. PROPN eurjchem-1667 180 46 ; ; PUNCT eurjchem-1667 180 47 ziemons ziemon NOUN eurjchem-1667 180 48 , , PUNCT eurjchem-1667 180 49 e. e. PROPN eurjchem-1667 180 50 int int PROPN eurjchem-1667 180 51 . . PUNCT eurjchem-1667 181 1 j. j. PROPN eurjchem-1667 181 2 pharm pharm PROPN eurjchem-1667 181 3 . . PUNCT eurjchem-1667 182 1 2015 2015 NUM eurjchem-1667 182 2 , , PUNCT eurjchem-1667 182 3 486 486 NUM eurjchem-1667 182 4 , , PUNCT eurjchem-1667 182 5 13‐20 13‐20 NUM eurjchem-1667 182 6 . . PUNCT eurjchem-1667 183 1 [ [ X eurjchem-1667 183 2 19 19 NUM eurjchem-1667 183 3 ] ] PUNCT eurjchem-1667 183 4 . . PUNCT eurjchem-1667 184 1 warnecke warnecke PROPN eurjchem-1667 184 2 , , PUNCT eurjchem-1667 184 3 s. s. PROPN eurjchem-1667 184 4 ; ; PUNCT eurjchem-1667 184 5 rinnan rinnan PROPN eurjchem-1667 184 6 , , PUNCT eurjchem-1667 184 7 a. a. NOUN eurjchem-1667 184 8 ; ; PUNCT eurjchem-1667 184 9 alleso alleso NOUN eurjchem-1667 184 10 , , PUNCT eurjchem-1667 184 11 m. m. NOUN eurjchem-1667 184 12 ; ; PUNCT eurjchem-1667 184 13 engelsen engelsen PROPN eurjchem-1667 184 14 , , PUNCT eurjchem-1667 184 15 s. s. PROPN eurjchem-1667 184 16 b. b. PROPN eurjchem-1667 184 17 appl appl PROPN eurjchem-1667 184 18 . . PROPN eurjchem-1667 184 19 spectrosc spectrosc PROPN eurjchem-1667 184 20 . . PUNCT eurjchem-1667 185 1 2015 2015 NUM eurjchem-1667 185 2 , , PUNCT eurjchem-1667 185 3 69(3 69(3 NUM eurjchem-1667 185 4 ) ) PUNCT eurjchem-1667 185 5 , , PUNCT eurjchem-1667 185 6 323‐331 323‐331 NUM eurjchem-1667 185 7 . . PUNCT eurjchem-1667 186 1 [ [ X eurjchem-1667 186 2 20 20 NUM eurjchem-1667 186 3 ] ] PUNCT eurjchem-1667 186 4 . . PUNCT eurjchem-1667 186 5 yan yan PROPN eurjchem-1667 186 6 , , PUNCT eurjchem-1667 186 7 b. b. PROPN eurjchem-1667 186 8 ; ; PUNCT eurjchem-1667 186 9 chen chen PROPN eurjchem-1667 186 10 , , PUNCT eurjchem-1667 186 11 t. t. PROPN eurjchem-1667 186 12 ; ; PUNCT eurjchem-1667 186 13 xu xu PROPN eurjchem-1667 186 14 , , PUNCT eurjchem-1667 186 15 z. z. PROPN eurjchem-1667 186 16 ; ; PUNCT eurjchem-1667 186 17 qu qu PROPN eurjchem-1667 186 18 , , PUNCT eurjchem-1667 186 19 h. h. PROPN eurjchem-1667 186 20 j. j. PROPN eurjchem-1667 186 21 pharm pharm PROPN eurjchem-1667 186 22 . . PUNCT eurjchem-1667 186 23 biomed biome VERB eurjchem-1667 186 24 . . PUNCT eurjchem-1667 187 1 anal anal PROPN eurjchem-1667 187 2 . . PUNCT eurjchem-1667 188 1 2014 2014 NUM eurjchem-1667 188 2 , , PUNCT eurjchem-1667 188 3 94 94 NUM eurjchem-1667 188 4 , , PUNCT eurjchem-1667 188 5 116‐ 116‐ NUM eurjchem-1667 188 6 110 110 NUM eurjchem-1667 188 7 . . PUNCT eurjchem-1667 189 1 [ [ X eurjchem-1667 189 2 21 21 NUM eurjchem-1667 189 3 ] ] PUNCT eurjchem-1667 189 4 . . PUNCT eurjchem-1667 190 1 jin jin PROPN eurjchem-1667 190 2 , , PUNCT eurjchem-1667 190 3 y. y. PROPN eurjchem-1667 190 4 ; ; PUNCT eurjchem-1667 190 5 wu wu PROPN eurjchem-1667 190 6 , , PUNCT eurjchem-1667 190 7 z. z. PROPN eurjchem-1667 190 8 ; ; PUNCT eurjchem-1667 190 9 liu liu PROPN eurjchem-1667 190 10 , , PUNCT eurjchem-1667 190 11 x. x. PROPN eurjchem-1667 190 12 ; ; PUNCT eurjchem-1667 190 13 wu wu PROPN eurjchem-1667 190 14 , , PUNCT eurjchem-1667 190 15 y. y. PROPN eurjchem-1667 190 16 j. j. PROPN eurjchem-1667 190 17 pharm pharm PROPN eurjchem-1667 190 18 . . PUNCT eurjchem-1667 190 19 biomed biome VERB eurjchem-1667 190 20 . . PUNCT eurjchem-1667 191 1 anal anal ADJ eurjchem-1667 191 2 . . PUNCT eurjchem-1667 192 1 2013 2013 NUM eurjchem-1667 192 2 , , PUNCT eurjchem-1667 192 3 77 77 NUM eurjchem-1667 192 4 , , PUNCT eurjchem-1667 192 5 32‐39 32‐39 NUM eurjchem-1667 192 6 . . PUNCT eurjchem-1667 193 1 [ [ X eurjchem-1667 193 2 22 22 NUM eurjchem-1667 193 3 ] ] PUNCT eurjchem-1667 193 4 . . PUNCT eurjchem-1667 194 1 simone simone PROPN eurjchem-1667 194 2 , , PUNCT eurjchem-1667 194 3 e. e. PROPN eurjchem-1667 194 4 ; ; PUNCT eurjchem-1667 194 5 zhang zhang PROPN eurjchem-1667 194 6 , , PUNCT eurjchem-1667 194 7 w. w. PROPN eurjchem-1667 194 8 ; ; PUNCT eurjchem-1667 194 9 nagy nagy PROPN eurjchem-1667 194 10 , , PUNCT eurjchem-1667 194 11 z. z. PROPN eurjchem-1667 194 12 k. k. PROPN eurjchem-1667 194 13 j. j. PROPN eurjchem-1667 194 14 chem chem PROPN eurjchem-1667 194 15 . . PUNCT eurjchem-1667 195 1 technol technol PROPN eurjchem-1667 195 2 . . PUNCT eurjchem-1667 195 3 biotechnol biotechnol PROPN eurjchem-1667 195 4 . . PUNCT eurjchem-1667 196 1 2016 2016 NUM eurjchem-1667 196 2 , , PUNCT eurjchem-1667 196 3 91 91 NUM eurjchem-1667 196 4 , , PUNCT eurjchem-1667 196 5 1461‐1470 1461‐1470 NUM eurjchem-1667 196 6 . . PUNCT eurjchem-1667 197 1 [ [ X eurjchem-1667 197 2 23 23 NUM eurjchem-1667 197 3 ] ] PUNCT eurjchem-1667 197 4 . . PUNCT eurjchem-1667 198 1 kim kim PROPN eurjchem-1667 198 2 , , PUNCT eurjchem-1667 198 3 d. d. PROPN eurjchem-1667 198 4 w. w. PROPN eurjchem-1667 198 5 ; ; PUNCT eurjchem-1667 198 6 park park PROPN eurjchem-1667 198 7 , , PUNCT eurjchem-1667 198 8 j. j. PROPN eurjchem-1667 198 9 b. b. PROPN eurjchem-1667 198 10 ; ; PUNCT eurjchem-1667 198 11 lee lee PROPN eurjchem-1667 198 12 , , PUNCT eurjchem-1667 198 13 s. s. PROPN eurjchem-1667 198 14 h. h. PROPN eurjchem-1667 198 15 ; ; PUNCT eurjchem-1667 198 16 weon weon PROPN eurjchem-1667 198 17 , , PUNCT eurjchem-1667 198 18 k. k. PROPN eurjchem-1667 198 19 y. y. PROPN eurjchem-1667 198 20 j. j. PROPN eurjchem-1667 198 21 drug drug PROPN eurjchem-1667 198 22 delivery delivery PROPN eurjchem-1667 198 23 sci sci PROPN eurjchem-1667 198 24 . . PROPN eurjchem-1667 198 25 technol technol PROPN eurjchem-1667 198 26 . . PROPN eurjchem-1667 198 27 2017 2017 NUM eurjchem-1667 198 28 , , PUNCT eurjchem-1667 198 29 39 39 NUM eurjchem-1667 198 30 , , PUNCT eurjchem-1667 198 31 8‐15 8‐15 NUM eurjchem-1667 198 32 . . PUNCT eurjchem-1667 199 1 [ [ X eurjchem-1667 199 2 24 24 NUM eurjchem-1667 199 3 ] ] PUNCT eurjchem-1667 199 4 . . PUNCT eurjchem-1667 199 5 rosas rosas PROPN eurjchem-1667 199 6 , , PUNCT eurjchem-1667 199 7 j. j. PROPN eurjchem-1667 199 8 g. g. PROPN eurjchem-1667 199 9 ; ; PUNCT eurjchem-1667 199 10 blanco blanco PROPN eurjchem-1667 199 11 , , PUNCT eurjchem-1667 199 12 m. m. NOUN eurjchem-1667 199 13 ; ; PUNCT eurjchem-1667 199 14 gonzalez gonzalez PROPN eurjchem-1667 199 15 , , PUNCT eurjchem-1667 199 16 j. j. PROPN eurjchem-1667 199 17 m. m. PROPN eurjchem-1667 199 18 ; ; PUNCT eurjchem-1667 199 19 alcala alcala PROPN eurjchem-1667 199 20 , , PUNCT eurjchem-1667 199 21 m. m. NOUN eurjchem-1667 199 22 talanta talanta PROPN eurjchem-1667 199 23 2012 2012 NUM eurjchem-1667 199 24 , , PUNCT eurjchem-1667 199 25 97 97 NUM eurjchem-1667 199 26 , , PUNCT eurjchem-1667 199 27 163‐170 163‐170 NUM eurjchem-1667 199 28 . . PUNCT eurjchem-1667 200 1 [ [ X eurjchem-1667 200 2 25 25 NUM eurjchem-1667 200 3 ] ] PUNCT eurjchem-1667 200 4 . . PUNCT eurjchem-1667 201 1 wu wu PROPN eurjchem-1667 201 2 , , PUNCT eurjchem-1667 201 3 y. y. PROPN eurjchem-1667 201 4 ; ; PUNCT eurjchem-1667 201 5 jin jin NOUN eurjchem-1667 201 6 , , PUNCT eurjchem-1667 201 7 y. y. PROPN eurjchem-1667 201 8 ; ; PUNCT eurjchem-1667 201 9 li li PROPN eurjchem-1667 201 10 , , PUNCT eurjchem-1667 201 11 y. y. PROPN eurjchem-1667 201 12 ; ; PUNCT eurjchem-1667 201 13 sun sun PROPN eurjchem-1667 201 14 , , PUNCT eurjchem-1667 201 15 d. d. PROPN eurjchem-1667 201 16 ; ; PUNCT eurjchem-1667 201 17 liu liu PROPN eurjchem-1667 201 18 , , PUNCT eurjchem-1667 201 19 x. x. PROPN eurjchem-1667 201 20 ; ; PUNCT eurjchem-1667 201 21 chen chen PROPN eurjchem-1667 201 22 , , PUNCT eurjchem-1667 201 23 y. y. PROPN eurjchem-1667 201 24 vib vib PROPN eurjchem-1667 201 25 . . PUNCT eurjchem-1667 201 26 spectrosc spectrosc PROPN eurjchem-1667 201 27 . . PUNCT eurjchem-1667 202 1 2012 2012 NUM eurjchem-1667 202 2 , , PUNCT eurjchem-1667 202 3 58 58 NUM eurjchem-1667 202 4 , , PUNCT eurjchem-1667 202 5 109‐118 109‐118 NUM eurjchem-1667 202 6 . . PUNCT