id	sid	tid	token	lemma	pos
eurjchem-1748	1	1	quinazolin	quinazolin	NOUN
eurjchem-1748	1	2	derivatives	derivative	NOUN
eurjchem-1748	1	3	as	as	ADP
eurjchem-1748	1	4	emerging	emerge	VERB
eurjchem-1748	1	5	alpha	alpha	NOUN
eurjchem-1748	1	6	-	-	PUNCT
eurjchem-1748	1	7	glucosidase	glucosidase	ADJ
eurjchem-1748	1	8	inhibitors	inhibitor	NOUN
eurjchem-1748	1	9	european	european	ADJ
eurjchem-1748	1	10	journal	journal	PROPN
eurjchem-1748	1	11	of	of	ADP
eurjchem-1748	1	12	chemistry	chemistry	NOUN
eurjchem-1748	1	13	9	9	NUM
eurjchem-1748	1	14	(	(	PUNCT
eurjchem-1748	1	15	4	4	NUM
eurjchem-1748	1	16	)	)	PUNCT
eurjchem-1748	1	17	(	(	PUNCT
eurjchem-1748	1	18	2018	2018	NUM
eurjchem-1748	1	19	)	)	PUNCT
eurjchem-1748	1	20	322	322	NUM
eurjchem-1748	1	21	-	-	SYM
eurjchem-1748	1	22	330	330	NUM
eurjchem-1748	1	23	european	european	ADJ
eurjchem-1748	1	24	journal	journal	NOUN
eurjchem-1748	1	25	of	of	ADP
eurjchem-1748	1	26	chemistry	chemistry	NOUN
eurjchem-1748	1	27	view	view	NOUN
eurjchem-1748	1	28	journal	journal	PROPN
eurjchem-1748	1	29	online	online	PROPN
eurjchem-1748	1	30	view	view	NOUN
eurjchem-1748	1	31	article	article	NOUN
eurjchem-1748	1	32	online	online	INTJ
eurjchem-1748	1	33	quinazolin	quinazolin	PROPN
eurjchem-1748	1	34	derivatives	derivative	NOUN
eurjchem-1748	1	35	as	as	ADP
eurjchem-1748	1	36	emerging	emerge	VERB
eurjchem-1748	1	37	alpha	alpha	NOUN
eurjchem-1748	1	38	-	-	PUNCT
eurjchem-1748	1	39	glucosidase	glucosidase	ADJ
eurjchem-1748	1	40	inhibitors	inhibitor	NOUN
eurjchem-1748	1	41	ashok	ashok	ADJ
eurjchem-1748	1	42	reddy	reddy	PROPN
eurjchem-1748	1	43	ankireddy	ankireddy	PROPN
eurjchem-1748	1	44	1	1	NUM
eurjchem-1748	1	45	,	,	PUNCT
eurjchem-1748	1	46	rambabu	rambabu	NOUN
eurjchem-1748	1	47	gundla	gundla	NOUN
eurjchem-1748	1	48	1	1	NUM
eurjchem-1748	1	49	,	,	PUNCT
eurjchem-1748	1	50	*	*	PUNCT
eurjchem-1748	1	51	,	,	PUNCT
eurjchem-1748	1	52	tuniki	tuniki	PROPN
eurjchem-1748	1	53	balaraju	balaraju	VERB
eurjchem-1748	1	54	2	2	NUM
eurjchem-1748	1	55	,	,	PUNCT
eurjchem-1748	1	56	venkanna	venkanna	NUM
eurjchem-1748	1	57	banothu	banothu	NOUN
eurjchem-1748	1	58	3	3	X
eurjchem-1748	1	59	,	,	PUNCT
eurjchem-1748	1	60	krishna	krishna	PROPN
eurjchem-1748	1	61	prasad	prasad	PROPN
eurjchem-1748	1	62	gundla	gundla	NOUN
eurjchem-1748	1	63	1	1	NUM
eurjchem-1748	1	64	,	,	PUNCT
eurjchem-1748	1	65	uma	uma	PROPN
eurjchem-1748	1	66	addepally	addepally	ADV
eurjchem-1748	1	67	3	3	NUM
eurjchem-1748	1	68	and	and	CCONJ
eurjchem-1748	1	69	jithendra	jithendra	NOUN
eurjchem-1748	1	70	chimakurthy	chimakurthy	VERB
eurjchem-1748	1	71	4	4	NUM
eurjchem-1748	1	72	1	1	NUM
eurjchem-1748	1	73	department	department	NOUN
eurjchem-1748	1	74	of	of	ADP
eurjchem-1748	1	75	chemistry	chemistry	NOUN
eurjchem-1748	1	76	,	,	PUNCT
eurjchem-1748	1	77	gitam	gitam	NOUN
eurjchem-1748	1	78	university	university	NOUN
eurjchem-1748	1	79	,	,	PUNCT
eurjchem-1748	1	80	hyderabad	hyderabad	PROPN
eurjchem-1748	1	81	,	,	PUNCT
eurjchem-1748	1	82	rudraram	rudraram	PROPN
eurjchem-1748	1	83	mandal	mandal	NOUN
eurjchem-1748	1	84	,	,	PUNCT
eurjchem-1748	1	85	sangareddy	sangareddy	NOUN
eurjchem-1748	1	86	district	district	PROPN
eurjchem-1748	1	87	,	,	PUNCT
eurjchem-1748	1	88	patancheru	patancheru	PROPN
eurjchem-1748	1	89	,	,	PUNCT
eurjchem-1748	1	90	hyderabad	hyderabad	PROPN
eurjchem-1748	1	91	,	,	PUNCT
eurjchem-1748	1	92	telangana	telangana	PROPN
eurjchem-1748	1	93	502329	502329	NUM
eurjchem-1748	1	94	,	,	PUNCT
eurjchem-1748	1	95	india	india	PROPN
eurjchem-1748	1	96	ankireddyashokreddy@gmail.com	ankireddyashokreddy@gmail.com	PROPN
eurjchem-1748	2	1	(	(	PUNCT
eurjchem-1748	2	2	a.r.a	a.r.a	PROPN
eurjchem-1748	2	3	.	.	PUNCT
eurjchem-1748	2	4	)	)	PUNCT
eurjchem-1748	2	5	,	,	PUNCT
eurjchem-1748	3	1	rambabu.gundla@gitam.edu	rambabu.gundla@gitam.edu	PROPN
eurjchem-1748	3	2	(	(	PUNCT
eurjchem-1748	3	3	g.r	g.r	PROPN
eurjchem-1748	3	4	.	.	PROPN
eurjchem-1748	3	5	)	)	PUNCT
eurjchem-1748	3	6	,	,	PUNCT
eurjchem-1748	3	7	krishnaprasadgundla@gmail.com	krishnaprasadgundla@gmail.com	X
eurjchem-1748	3	8	(	(	PUNCT
eurjchem-1748	3	9	k.p.g	k.p.g	PROPN
eurjchem-1748	3	10	.	.	PUNCT
eurjchem-1748	3	11	)	)	PUNCT
eurjchem-1748	4	1	2	2	NUM
eurjchem-1748	4	2	department	department	NOUN
eurjchem-1748	4	3	of	of	ADP
eurjchem-1748	4	4	chemistry	chemistry	NOUN
eurjchem-1748	4	5	,	,	PUNCT
eurjchem-1748	4	6	birla	birla	PROPN
eurjchem-1748	4	7	institute	institute	PROPN
eurjchem-1748	4	8	of	of	ADP
eurjchem-1748	4	9	technology	technology	PROPN
eurjchem-1748	4	10	,	,	PUNCT
eurjchem-1748	4	11	mesra	mesra	PROPN
eurjchem-1748	4	12	,	,	PUNCT
eurjchem-1748	4	13	jharkhand	jharkhand	PROPN
eurjchem-1748	4	14	835215	835215	NUM
eurjchem-1748	4	15	,	,	PUNCT
eurjchem-1748	4	16	india	india	PROPN
eurjchem-1748	4	17	balarajutuniki@gmail.com	balarajutuniki@gmail.com	PROPN
eurjchem-1748	4	18	(	(	PUNCT
eurjchem-1748	4	19	t.b	t.b	PROPN
eurjchem-1748	4	20	.	.	PROPN
eurjchem-1748	4	21	)	)	PUNCT
eurjchem-1748	4	22	3	3	NUM
eurjchem-1748	4	23	centre	centre	NOUN
eurjchem-1748	4	24	for	for	ADP
eurjchem-1748	4	25	biotechnology	biotechnology	NOUN
eurjchem-1748	4	26	(	(	PUNCT
eurjchem-1748	4	27	cbt	cbt	NOUN
eurjchem-1748	4	28	)	)	PUNCT
eurjchem-1748	4	29	,	,	PUNCT
eurjchem-1748	4	30	institute	institute	NOUN
eurjchem-1748	4	31	of	of	ADP
eurjchem-1748	4	32	science	science	PROPN
eurjchem-1748	4	33	&	&	CCONJ
eurjchem-1748	4	34	technology	technology	PROPN
eurjchem-1748	4	35	(	(	PUNCT
eurjchem-1748	4	36	ist	ist	NOUN
eurjchem-1748	4	37	)	)	PUNCT
eurjchem-1748	4	38	,	,	PUNCT
eurjchem-1748	4	39	jawaharlal	jawaharlal	PROPN
eurjchem-1748	4	40	nehru	nehru	PROPN
eurjchem-1748	4	41	technological	technological	PROPN
eurjchem-1748	4	42	university	university	NOUN
eurjchem-1748	4	43	hyderabad	hyderabad	NOUN
eurjchem-1748	4	44	(	(	PUNCT
eurjchem-1748	4	45	jntuh	jntuh	PROPN
eurjchem-1748	4	46	)	)	PUNCT
eurjchem-1748	4	47	,	,	PUNCT
eurjchem-1748	4	48	kukatpally	kukatpally	ADV
eurjchem-1748	4	49	,	,	PUNCT
eurjchem-1748	4	50	hyderabad	hyderabad	PROPN
eurjchem-1748	4	51	,	,	PUNCT
eurjchem-1748	4	52	telangana	telangana	PROPN
eurjchem-1748	4	53	state	state	PROPN
eurjchem-1748	4	54	,	,	PUNCT
eurjchem-1748	4	55	500085	500085	NUM
eurjchem-1748	4	56	,	,	PUNCT
eurjchem-1748	4	57	india	india	PROPN
eurjchem-1748	4	58	venky.bt@gmail.com	venky.bt@gmail.com	PROPN
eurjchem-1748	4	59	(	(	PUNCT
eurjchem-1748	4	60	v.b	v.b	PROPN
eurjchem-1748	4	61	.	.	PROPN
eurjchem-1748	4	62	)	)	PUNCT
eurjchem-1748	4	63	,	,	PUNCT
eurjchem-1748	4	64	vedavathi1@gmail.com	vedavathi1@gmail.com	X
eurjchem-1748	4	65	(	(	PUNCT
eurjchem-1748	4	66	u.a	u.a	PROPN
eurjchem-1748	4	67	.	.	PROPN
eurjchem-1748	4	68	)	)	PUNCT
eurjchem-1748	5	1	4	4	NUM
eurjchem-1748	5	2	department	department	NOUN
eurjchem-1748	5	3	of	of	ADP
eurjchem-1748	5	4	pharmaceutical	pharmaceutical	NOUN
eurjchem-1748	5	5	sciences	sciences	PROPN
eurjchem-1748	5	6	,	,	PUNCT
eurjchem-1748	5	7	vignan	vignan	NOUN
eurjchem-1748	5	8	’s	’s	PART
eurjchem-1748	5	9	foundation	foundation	PROPN
eurjchem-1748	5	10	for	for	ADP
eurjchem-1748	5	11	science	science	NOUN
eurjchem-1748	5	12	,	,	PUNCT
eurjchem-1748	5	13	technology	technology	NOUN
eurjchem-1748	5	14	and	and	CCONJ
eurjchem-1748	5	15	research	research	NOUN
eurjchem-1748	5	16	vadlamudi	vadlamudi	NOUN
eurjchem-1748	5	17	,	,	PUNCT
eurjchem-1748	5	18	guntur	guntur	PROPN
eurjchem-1748	5	19	,	,	PUNCT
eurjchem-1748	5	20	andhra	andhra	PROPN
eurjchem-1748	5	21	pradesh	pradesh	PROPN
eurjchem-1748	5	22	522213	522213	NUM
eurjchem-1748	5	23	,	,	PUNCT
eurjchem-1748	5	24	india	india	PROPN
eurjchem-1748	5	25	jithendrach@gmail.com	jithendrach@gmail.com	PROPN
eurjchem-1748	5	26	(	(	PUNCT
eurjchem-1748	5	27	j.c	j.c	PROPN
eurjchem-1748	5	28	.	.	PROPN
eurjchem-1748	5	29	)	)	PUNCT
eurjchem-1748	6	1	*	*	PUNCT
eurjchem-1748	6	2	corresponding	correspond	VERB
eurjchem-1748	6	3	author	author	NOUN
eurjchem-1748	6	4	at	at	ADP
eurjchem-1748	6	5	:	:	PUNCT
eurjchem-1748	6	6	department	department	NOUN
eurjchem-1748	6	7	of	of	ADP
eurjchem-1748	6	8	chemistry	chemistry	NOUN
eurjchem-1748	6	9	,	,	PUNCT
eurjchem-1748	6	10	gitam	gitam	NOUN
eurjchem-1748	6	11	university	university	NOUN
eurjchem-1748	6	12	,	,	PUNCT
eurjchem-1748	6	13	hyderabad	hyderabad	PROPN
eurjchem-1748	6	14	,	,	PUNCT
eurjchem-1748	6	15	rudraram	rudraram	PROPN
eurjchem-1748	6	16	mandal	mandal	NOUN
eurjchem-1748	6	17	,	,	PUNCT
eurjchem-1748	6	18	sangareddy	sangareddy	NOUN
eurjchem-1748	6	19	district	district	PROPN
eurjchem-1748	6	20	,	,	PUNCT
eurjchem-1748	6	21	patancheru	patancheru	PROPN
eurjchem-1748	6	22	,	,	PUNCT
eurjchem-1748	6	23	hyderabad	hyderabad	PROPN
eurjchem-1748	6	24	,	,	PUNCT
eurjchem-1748	6	25	telangana	telangana	PROPN
eurjchem-1748	6	26	502329	502329	NUM
eurjchem-1748	6	27	,	,	PUNCT
eurjchem-1748	6	28	india	india	PROPN
eurjchem-1748	6	29	.	.	PUNCT
eurjchem-1748	7	1	tel	tel	ADP
eurjchem-1748	7	2	:	:	PUNCT
eurjchem-1748	7	3	+91.863.2344700	+91.863.2344700	NUM
eurjchem-1748	7	4	fax	fax	NOUN
eurjchem-1748	7	5	:	:	PUNCT
eurjchem-1748	7	6	+91.863.2344700	+91.863.2344700	NUM
eurjchem-1748	7	7	e	e	NOUN
eurjchem-1748	7	8	-	-	NOUN
eurjchem-1748	7	9	mail	mail	NOUN
eurjchem-1748	7	10	:	:	PUNCT
eurjchem-1748	7	11	rambabu.gundla@gitam.edu	rambabu.gundla@gitam.edu	PROPN
eurjchem-1748	7	12	(	(	PUNCT
eurjchem-1748	7	13	g.	g.	PROPN
eurjchem-1748	7	14	rambabu	rambabu	NOUN
eurjchem-1748	7	15	)	)	PUNCT
eurjchem-1748	7	16	.	.	PUNCT
eurjchem-1748	8	1	10.5155	10.5155	NUM
eurjchem-1748	8	2	/	/	SYM
eurjchem-1748	8	3	eurjchem.9.4.322	eurjchem.9.4.322	PROPN
eurjchem-1748	8	4	-	-	SYM
eurjchem-1748	8	5	330.1748	330.1748	NUM
eurjchem-1748	8	6	received	receive	VERB
eurjchem-1748	8	7	:	:	PUNCT
eurjchem-1748	8	8	29	29	NUM
eurjchem-1748	8	9	may	may	AUX
eurjchem-1748	8	10	2018	2018	NUM
eurjchem-1748	8	11	received	receive	VERB
eurjchem-1748	8	12	in	in	ADP
eurjchem-1748	8	13	revised	revise	VERB
eurjchem-1748	8	14	form	form	NOUN
eurjchem-1748	8	15	:	:	PUNCT
eurjchem-1748	8	16	01	01	NUM
eurjchem-1748	8	17	september	september	PROPN
eurjchem-1748	8	18	2018	2018	NUM
eurjchem-1748	8	19	accepted	accept	VERB
eurjchem-1748	8	20	:	:	PUNCT
eurjchem-1748	8	21	06	06	NUM
eurjchem-1748	8	22	september	september	PROPN
eurjchem-1748	8	23	2018	2018	NUM
eurjchem-1748	8	24	published	publish	VERB
eurjchem-1748	8	25	online	online	ADV
eurjchem-1748	8	26	:	:	PUNCT
eurjchem-1748	8	27	31	31	NUM
eurjchem-1748	8	28	december	december	PROPN
eurjchem-1748	8	29	2018	2018	NUM
eurjchem-1748	8	30	printed	print	VERB
eurjchem-1748	8	31	:	:	PUNCT
eurjchem-1748	8	32	31	31	NUM
eurjchem-1748	8	33	december	december	PROPN
eurjchem-1748	8	34	2018	2018	NUM
eurjchem-1748	8	35	a	a	DET
eurjchem-1748	8	36	series	series	NOUN
eurjchem-1748	8	37	of	of	ADP
eurjchem-1748	8	38	c-7	c-7	PROPN
eurjchem-1748	8	39	substituted-2	substituted-2	NOUN
eurjchem-1748	8	40	-	-	PUNCT
eurjchem-1748	8	41	morpholino	morpholino	NOUN
eurjchem-1748	8	42	-	-	PUNCT
eurjchem-1748	8	43	n-(pyridin-2	n-(pyridin-2	NUM
eurjchem-1748	8	44	-	-	PUNCT
eurjchem-1748	8	45	ylmethyl)quinazolin-4	ylmethyl)quinazolin-4	NOUN
eurjchem-1748	8	46	-	-	PUNCT
eurjchem-1748	8	47	amine	amine	NOUN
eurjchem-1748	8	48	have	have	AUX
eurjchem-1748	8	49	been	be	AUX
eurjchem-1748	8	50	synthesized	synthesize	VERB
eurjchem-1748	8	51	and	and	CCONJ
eurjchem-1748	8	52	biochemical	biochemical	ADJ
eurjchem-1748	8	53	assay	assay	NOUN
eurjchem-1748	8	54	was	be	AUX
eurjchem-1748	8	55	examined	examine	VERB
eurjchem-1748	8	56	against	against	ADP
eurjchem-1748	8	57	α	α	NOUN
eurjchem-1748	8	58	-	-	PUNCT
eurjchem-1748	8	59	glucosidase	glucosidase	ADJ
eurjchem-1748	8	60	function	function	NOUN
eurjchem-1748	8	61	inhibition	inhibition	NOUN
eurjchem-1748	8	62	activity	activity	NOUN
eurjchem-1748	8	63	.	.	PUNCT
eurjchem-1748	9	1	a	a	DET
eurjchem-1748	9	2	structure	structure	NOUN
eurjchem-1748	9	3	activity	activity	NOUN
eurjchem-1748	9	4	and	and	CCONJ
eurjchem-1748	9	5	structure	structure	NOUN
eurjchem-1748	9	6	property	property	NOUN
eurjchem-1748	9	7	relationship	relationship	NOUN
eurjchem-1748	9	8	study	study	NOUN
eurjchem-1748	9	9	was	be	AUX
eurjchem-1748	9	10	experimented	experiment	VERB
eurjchem-1748	9	11	to	to	PART
eurjchem-1748	9	12	surface	surface	VERB
eurjchem-1748	9	13	the	the	DET
eurjchem-1748	9	14	new	new	ADJ
eurjchem-1748	9	15	hit	hit	NOUN
eurjchem-1748	9	16	compound	compound	NOUN
eurjchem-1748	9	17	.	.	PUNCT
eurjchem-1748	10	1	this	this	DET
eurjchem-1748	10	2	study	study	NOUN
eurjchem-1748	10	3	led	lead	VERB
eurjchem-1748	10	4	to	to	ADP
eurjchem-1748	10	5	the	the	DET
eurjchem-1748	10	6	identification	identification	NOUN
eurjchem-1748	10	7	of	of	ADP
eurjchem-1748	10	8	c7substituted	c7substitute	VERB
eurjchem-1748	10	9	quinazolines	quinazoline	NOUN
eurjchem-1748	10	10	with	with	ADP
eurjchem-1748	10	11	minimum	minimum	ADJ
eurjchem-1748	10	12	inhibitory	inhibitory	ADJ
eurjchem-1748	10	13	concentrations	concentration	NOUN
eurjchem-1748	10	14	(	(	PUNCT
eurjchem-1748	10	15	mics	mic	NOUN
eurjchem-1748	10	16	)	)	PUNCT
eurjchem-1748	10	17	in	in	ADP
eurjchem-1748	10	18	the	the	DET
eurjchem-1748	10	19	preffered	preffered	ADJ
eurjchem-1748	10	20	micromolar	micromolar	ADJ
eurjchem-1748	10	21	range	range	NOUN
eurjchem-1748	10	22	in	in	ADP
eurjchem-1748	10	23	addition	addition	NOUN
eurjchem-1748	10	24	with	with	ADP
eurjchem-1748	10	25	interesting	interesting	ADJ
eurjchem-1748	10	26	physicochemical	physicochemical	ADJ
eurjchem-1748	10	27	properties	property	NOUN
eurjchem-1748	10	28	.	.	PUNCT
eurjchem-1748	11	1	biological	biological	ADJ
eurjchem-1748	11	2	evaluation	evaluation	NOUN
eurjchem-1748	11	3	yielded	yield	VERB
eurjchem-1748	11	4	eight	eight	NUM
eurjchem-1748	11	5	analogs	analog	NOUN
eurjchem-1748	11	6	which	which	PRON
eurjchem-1748	11	7	rose	rise	VERB
eurjchem-1748	11	8	with	with	ADP
eurjchem-1748	11	9	significant	significant	ADJ
eurjchem-1748	11	10	α	α	NOUN
eurjchem-1748	11	11	-	-	ADJ
eurjchem-1748	11	12	glucosidase	glucosidase	ADJ
eurjchem-1748	11	13	inhibition	inhibition	NOUN
eurjchem-1748	11	14	potency	potency	NOUN
eurjchem-1748	11	15	(	(	PUNCT
eurjchem-1748	11	16	ic50	ic50	PROPN
eurjchem-1748	11	17	values	value	VERB
eurjchem-1748	11	18	<	<	X
eurjchem-1748	11	19	2	2	NUM
eurjchem-1748	11	20	μm	μm	NOUN
eurjchem-1748	11	21	,	,	PUNCT
eurjchem-1748	11	22	where	where	SCONJ
eurjchem-1748	11	23	reference	reference	NOUN
eurjchem-1748	11	24	compound	compound	NOUN
eurjchem-1748	11	25	(	(	PUNCT
eurjchem-1748	11	26	acarbose	acarbose	NOUN
eurjchem-1748	11	27	)	)	PUNCT
eurjchem-1748	11	28	potency	potency	NOUN
eurjchem-1748	11	29	value	value	NOUN
eurjchem-1748	11	30	is	be	AUX
eurjchem-1748	11	31	ic50	ic50	PROPN
eurjchem-1748	11	32	=	=	PROPN
eurjchem-1748	11	33	0.586	0.586	NUM
eurjchem-1748	11	34	um	um	INTJ
eurjchem-1748	11	35	)	)	PUNCT
eurjchem-1748	11	36	and	and	CCONJ
eurjchem-1748	11	37	could	could	AUX
eurjchem-1748	11	38	be	be	AUX
eurjchem-1748	11	39	promising	promise	VERB
eurjchem-1748	11	40	candidates	candidate	NOUN
eurjchem-1748	11	41	for	for	ADP
eurjchem-1748	11	42	further	further	ADJ
eurjchem-1748	11	43	lead	lead	NOUN
eurjchem-1748	11	44	optimization	optimization	NOUN
eurjchem-1748	11	45	.	.	PUNCT
eurjchem-1748	12	1	diabetes	diabetes	NOUN
eurjchem-1748	12	2	acarbose	acarbose	VERB
eurjchem-1748	12	3	inhibitors	inhibitor	NOUN
eurjchem-1748	12	4	inflammation	inflammation	VERB
eurjchem-1748	12	5	alpha	alpha	NOUN
eurjchem-1748	12	6	-	-	PUNCT
eurjchem-1748	12	7	glucosidase	glucosidase	ADJ
eurjchem-1748	12	8	quninazoline	quninazoline	NOUN
eurjchem-1748	12	9	derivatives	derivative	NOUN
eurjchem-1748	12	10	cite	cite	VERB
eurjchem-1748	12	11	this	this	PRON
eurjchem-1748	12	12	:	:	PUNCT
eurjchem-1748	13	1	eur	eur	PROPN
eurjchem-1748	13	2	.	.	PUNCT
eurjchem-1748	14	1	j.	j.	PROPN
eurjchem-1748	14	2	chem	chem	PROPN
eurjchem-1748	14	3	.	.	PUNCT
eurjchem-1748	15	1	2018	2018	NUM
eurjchem-1748	15	2	,	,	PUNCT
eurjchem-1748	15	3	9(4	9(4	NUM
eurjchem-1748	15	4	)	)	PUNCT
eurjchem-1748	15	5	,	,	PUNCT
eurjchem-1748	15	6	322	322	NUM
eurjchem-1748	15	7	-	-	SYM
eurjchem-1748	15	8	330	330	NUM
eurjchem-1748	15	9	journal	journal	NOUN
eurjchem-1748	15	10	website	website	NOUN
eurjchem-1748	15	11	:	:	PUNCT
eurjchem-1748	15	12	www.eurjchem.com	www.eurjchem.com	X
eurjchem-1748	15	13	1	1	X
eurjchem-1748	15	14	.	.	X
eurjchem-1748	16	1	introduction	introduction	NOUN
eurjchem-1748	16	2	the	the	DET
eurjchem-1748	16	3	complex	complex	ADJ
eurjchem-1748	16	4	and	and	CCONJ
eurjchem-1748	16	5	acute	acute	ADJ
eurjchem-1748	16	6	health	health	NOUN
eurjchem-1748	16	7	condition	condition	NOUN
eurjchem-1748	16	8	of	of	ADP
eurjchem-1748	16	9	the	the	DET
eurjchem-1748	16	10	current	current	ADJ
eurjchem-1748	16	11	generation	generation	NOUN
eurjchem-1748	16	12	which	which	PRON
eurjchem-1748	16	13	rise	rise	VERB
eurjchem-1748	16	14	from	from	ADP
eurjchem-1748	16	15	irregular	irregular	ADJ
eurjchem-1748	16	16	or	or	CCONJ
eurjchem-1748	16	17	excess	excess	ADJ
eurjchem-1748	16	18	food	food	NOUN
eurjchem-1748	16	19	consumption	consumption	NOUN
eurjchem-1748	16	20	,	,	PUNCT
eurjchem-1748	16	21	lack	lack	NOUN
eurjchem-1748	16	22	of	of	ADP
eurjchem-1748	16	23	regular	regular	ADJ
eurjchem-1748	16	24	exercise	exercise	NOUN
eurjchem-1748	16	25	(	(	PUNCT
eurjchem-1748	16	26	physical	physical	NOUN
eurjchem-1748	16	27	)	)	PUNCT
eurjchem-1748	16	28	or	or	CCONJ
eurjchem-1748	16	29	rarely	rarely	ADV
eurjchem-1748	16	30	genetically	genetically	ADV
eurjchem-1748	16	31	that	that	PRON
eurjchem-1748	16	32	is	be	AUX
eurjchem-1748	16	33	diabetes	diabetes	NOUN
eurjchem-1748	16	34	mellitus	mellitus	NOUN
eurjchem-1748	16	35	delineate	delineate	VERB
eurjchem-1748	16	36	the	the	DET
eurjchem-1748	16	37	critical	critical	ADJ
eurjchem-1748	16	38	metabolic	metabolic	NOUN
eurjchem-1748	16	39	disorder	disorder	NOUN
eurjchem-1748	16	40	of	of	ADP
eurjchem-1748	16	41	multiple	multiple	ADJ
eurjchem-1748	16	42	etiologies	etiology	NOUN
eurjchem-1748	16	43	characterized	characterize	VERB
eurjchem-1748	16	44	by	by	ADP
eurjchem-1748	16	45	chronic	chronic	ADJ
eurjchem-1748	16	46	hyperglycemia	hyperglycemia	NOUN
eurjchem-1748	16	47	with	with	ADP
eurjchem-1748	16	48	disturbances	disturbance	NOUN
eurjchem-1748	16	49	of	of	ADP
eurjchem-1748	16	50	carbohydrate	carbohydrate	NOUN
eurjchem-1748	16	51	,	,	PUNCT
eurjchem-1748	16	52	fat	fat	ADJ
eurjchem-1748	16	53	and	and	CCONJ
eurjchem-1748	16	54	protein	protein	NOUN
eurjchem-1748	16	55	metabolism	metabolism	NOUN
eurjchem-1748	16	56	,	,	PUNCT
eurjchem-1748	16	57	consequences	consequence	VERB
eurjchem-1748	16	58	defects	defect	NOUN
eurjchem-1748	16	59	in	in	ADP
eurjchem-1748	16	60	insulin	insulin	NOUN
eurjchem-1748	16	61	secretion	secretion	NOUN
eurjchem-1748	16	62	,	,	PUNCT
eurjchem-1748	16	63	action	action	NOUN
eurjchem-1748	16	64	and	and	CCONJ
eurjchem-1748	16	65	frequently	frequently	ADV
eurjchem-1748	16	66	both	both	PRON
eurjchem-1748	16	67	.	.	PUNCT
eurjchem-1748	17	1	according	accord	VERB
eurjchem-1748	17	2	to	to	ADP
eurjchem-1748	17	3	a	a	DET
eurjchem-1748	17	4	recent	recent	ADJ
eurjchem-1748	17	5	pandect	pandect	NOUN
eurjchem-1748	17	6	approximately	approximately	ADV
eurjchem-1748	17	7	366	366	NUM
eurjchem-1748	17	8	million	million	NUM
eurjchem-1748	17	9	people	people	NOUN
eurjchem-1748	17	10	are	be	AUX
eurjchem-1748	17	11	suffering	suffer	VERB
eurjchem-1748	17	12	from	from	ADP
eurjchem-1748	17	13	this	this	DET
eurjchem-1748	17	14	health	health	NOUN
eurjchem-1748	17	15	disorder	disorder	NOUN
eurjchem-1748	17	16	across	across	ADP
eurjchem-1748	17	17	the	the	DET
eurjchem-1748	17	18	globe	globe	NOUN
eurjchem-1748	17	19	and	and	CCONJ
eurjchem-1748	17	20	this	this	DET
eurjchem-1748	17	21	number	number	NOUN
eurjchem-1748	17	22	is	be	AUX
eurjchem-1748	17	23	estimated	estimate	VERB
eurjchem-1748	17	24	to	to	PART
eurjchem-1748	17	25	increase	increase	VERB
eurjchem-1748	17	26	522	522	NUM
eurjchem-1748	17	27	million	million	NUM
eurjchem-1748	17	28	by	by	ADP
eurjchem-1748	17	29	2030	2030	NUM
eurjchem-1748	18	1	[	[	X
eurjchem-1748	18	2	1	1	NUM
eurjchem-1748	18	3	]	]	PUNCT
eurjchem-1748	18	4	.	.	PUNCT
eurjchem-1748	19	1	it	it	PRON
eurjchem-1748	19	2	is	be	AUX
eurjchem-1748	19	3	also	also	ADV
eurjchem-1748	19	4	a	a	DET
eurjchem-1748	19	5	common	common	ADJ
eurjchem-1748	19	6	endocrine	endocrine	NOUN
eurjchem-1748	19	7	disorder	disorder	NOUN
eurjchem-1748	19	8	characterized	characterize	VERB
eurjchem-1748	19	9	by	by	ADP
eurjchem-1748	19	10	hyperglycemia	hyperglycemia	NOUN
eurjchem-1748	19	11	,	,	PUNCT
eurjchem-1748	19	12	which	which	PRON
eurjchem-1748	19	13	has	have	AUX
eurjchem-1748	19	14	become	become	VERB
eurjchem-1748	19	15	a	a	DET
eurjchem-1748	19	16	major	major	ADJ
eurjchem-1748	19	17	risk	risk	NOUN
eurjchem-1748	19	18	to	to	ADP
eurjchem-1748	19	19	the	the	DET
eurjchem-1748	19	20	individual	individual	NOUN
eurjchem-1748	19	21	’s	’s	PART
eurjchem-1748	19	22	quality	quality	NOUN
eurjchem-1748	19	23	of	of	ADP
eurjchem-1748	19	24	life	life	NOUN
eurjchem-1748	19	25	.	.	PUNCT
eurjchem-1748	20	1	the	the	DET
eurjchem-1748	20	2	effects	effect	NOUN
eurjchem-1748	20	3	of	of	ADP
eurjchem-1748	20	4	diabetes	diabetes	NOUN
eurjchem-1748	20	5	mellitus	mellitus	NOUN
eurjchem-1748	20	6	include	include	VERB
eurjchem-1748	20	7	long	long	ADJ
eurjchem-1748	20	8	-	-	PUNCT
eurjchem-1748	20	9	term	term	NOUN
eurjchem-1748	20	10	damage	damage	NOUN
eurjchem-1748	20	11	,	,	PUNCT
eurjchem-1748	20	12	dysfunction	dysfunction	NOUN
eurjchem-1748	20	13	and	and	CCONJ
eurjchem-1748	20	14	failure	failure	NOUN
eurjchem-1748	20	15	of	of	ADP
eurjchem-1748	20	16	various	various	ADJ
eurjchem-1748	20	17	organs	organ	NOUN
eurjchem-1748	20	18	.	.	PUNCT
eurjchem-1748	21	1	it	it	PRON
eurjchem-1748	21	2	may	may	AUX
eurjchem-1748	21	3	present	present	VERB
eurjchem-1748	21	4	with	with	ADP
eurjchem-1748	21	5	characteristic	characteristic	ADJ
eurjchem-1748	21	6	symptoms	symptom	NOUN
eurjchem-1748	21	7	such	such	ADJ
eurjchem-1748	21	8	as	as	ADP
eurjchem-1748	21	9	thirst	thirst	NOUN
eurjchem-1748	21	10	,	,	PUNCT
eurjchem-1748	21	11	polyuria	polyuria	NOUN
eurjchem-1748	21	12	,	,	PUNCT
eurjchem-1748	21	13	blurring	blurring	NOUN
eurjchem-1748	21	14	of	of	ADP
eurjchem-1748	21	15	vision	vision	NOUN
eurjchem-1748	21	16	,	,	PUNCT
eurjchem-1748	21	17	and	and	CCONJ
eurjchem-1748	21	18	weight	weight	NOUN
eurjchem-1748	21	19	loss	loss	NOUN
eurjchem-1748	21	20	,	,	PUNCT
eurjchem-1748	21	21	in	in	ADP
eurjchem-1748	21	22	its	its	PRON
eurjchem-1748	21	23	most	most	ADV
eurjchem-1748	21	24	severe	severe	ADJ
eurjchem-1748	21	25	forms	form	NOUN
eurjchem-1748	21	26	ketoacidosis	ketoacidosis	NOUN
eurjchem-1748	21	27	or	or	CCONJ
eurjchem-1748	21	28	a	a	DET
eurjchem-1748	21	29	non	non	ADJ
eurjchem-1748	21	30	-	-	ADJ
eurjchem-1748	21	31	ketotic	ketotic	ADJ
eurjchem-1748	21	32	hyperosmolar	hyperosmolar	ADJ
eurjchem-1748	21	33	state	state	NOUN
eurjchem-1748	21	34	may	may	AUX
eurjchem-1748	21	35	raise	raise	VERB
eurjchem-1748	21	36	and	and	CCONJ
eurjchem-1748	21	37	lead	lead	VERB
eurjchem-1748	21	38	to	to	ADP
eurjchem-1748	21	39	apathy	apathy	NOUN
eurjchem-1748	21	40	,	,	PUNCT
eurjchem-1748	21	41	coma	coma	NOUN
eurjchem-1748	21	42	and	and	CCONJ
eurjchem-1748	21	43	in	in	ADP
eurjchem-1748	21	44	absence	absence	NOUN
eurjchem-1748	21	45	of	of	ADP
eurjchem-1748	21	46	effective	effective	ADJ
eurjchem-1748	21	47	treatment	treatment	NOUN
eurjchem-1748	21	48	leads	lead	VERB
eurjchem-1748	21	49	to	to	ADP
eurjchem-1748	21	50	death	death	NOUN
eurjchem-1748	21	51	[	[	X
eurjchem-1748	21	52	2	2	NUM
eurjchem-1748	21	53	]	]	PUNCT
eurjchem-1748	21	54	.	.	PUNCT
eurjchem-1748	22	1	with	with	ADP
eurjchem-1748	22	2	subject	subject	NOUN
eurjchem-1748	22	3	to	to	ADP
eurjchem-1748	22	4	control	control	VERB
eurjchem-1748	22	5	this	this	DET
eurjchem-1748	22	6	particular	particular	ADJ
eurjchem-1748	22	7	disease	disease	NOUN
eurjchem-1748	22	8	,	,	PUNCT
eurjchem-1748	22	9	one	one	NUM
eurjchem-1748	22	10	of	of	ADP
eurjchem-1748	22	11	the	the	DET
eurjchem-1748	22	12	best	well	ADV
eurjchem-1748	22	13	-	-	PUNCT
eurjchem-1748	22	14	studied	study	VERB
eurjchem-1748	22	15	therapeutic	therapeutic	ADJ
eurjchem-1748	22	16	target	target	NOUN
eurjchem-1748	22	17	is	be	AUX
eurjchem-1748	22	18	α	α	NOUN
eurjchem-1748	22	19	-	-	NOUN
eurjchem-1748	22	20	glucosidase	glucosidase	ADJ
eurjchem-1748	22	21	and	and	CCONJ
eurjchem-1748	22	22	its	its	PRON
eurjchem-1748	22	23	function	function	NOUN
eurjchem-1748	22	24	inhibition	inhibition	NOUN
eurjchem-1748	22	25	.	.	PUNCT
eurjchem-1748	23	1	it	it	PRON
eurjchem-1748	23	2	is	be	AUX
eurjchem-1748	23	3	located	locate	VERB
eurjchem-1748	23	4	in	in	ADP
eurjchem-1748	23	5	the	the	DET
eurjchem-1748	23	6	brush	brush	NOUN
eurjchem-1748	23	7	border	border	NOUN
eurjchem-1748	23	8	of	of	ADP
eurjchem-1748	23	9	the	the	DET
eurjchem-1748	23	10	small	small	ADJ
eurjchem-1748	23	11	intestine	intestine	NOUN
eurjchem-1748	23	12	[	[	X
eurjchem-1748	23	13	3	3	NUM
eurjchem-1748	23	14	-	-	SYM
eurjchem-1748	23	15	7	7	NUM
eurjchem-1748	23	16	]	]	PUNCT
eurjchem-1748	23	17	and	and	CCONJ
eurjchem-1748	23	18	involved	involve	VERB
eurjchem-1748	23	19	in	in	ADP
eurjchem-1748	23	20	breaking	break	VERB
eurjchem-1748	23	21	down	down	ADP
eurjchem-1748	23	22	complex	complex	ADJ
eurjchem-1748	23	23	carbohydrates	carbohydrate	NOUN
eurjchem-1748	23	24	such	such	ADJ
eurjchem-1748	23	25	as	as	ADP
eurjchem-1748	23	26	starch	starch	NOUN
eurjchem-1748	23	27	and	and	CCONJ
eurjchem-1748	23	28	glycogen	glycogen	NOUN
eurjchem-1748	23	29	into	into	ADP
eurjchem-1748	23	30	their	their	PRON
eurjchem-1748	23	31	monomers	monomer	NOUN
eurjchem-1748	23	32	,	,	PUNCT
eurjchem-1748	23	33	it	it	PRON
eurjchem-1748	23	34	catalyzes	catalyze	VERB
eurjchem-1748	23	35	the	the	DET
eurjchem-1748	23	36	cleavage	cleavage	NOUN
eurjchem-1748	23	37	of	of	ADP
eurjchem-1748	23	38	individual	individual	ADJ
eurjchem-1748	23	39	glucosyl	glucosyl	NOUN
eurjchem-1748	23	40	residues	residue	NOUN
eurjchem-1748	23	41	from	from	ADP
eurjchem-1748	23	42	various	various	ADJ
eurjchem-1748	23	43	glycoconjugates	glycoconjugate	NOUN
eurjchem-1748	23	44	including	include	VERB
eurjchem-1748	23	45	alpha	alpha	NOUN
eurjchem-1748	23	46	or	or	CCONJ
eurjchem-1748	23	47	beta	beta	NOUN
eurjchem-1748	23	48	linked	link	VERB
eurjchem-1748	23	49	polymers	polymer	NOUN
eurjchem-1748	23	50	of	of	ADP
eurjchem-1748	23	51	glucose	glucose	NOUN
eurjchem-1748	23	52	.	.	PUNCT
eurjchem-1748	24	1	the	the	DET
eurjchem-1748	24	2	body	body	NOUN
eurjchem-1748	24	3	system	system	NOUN
eurjchem-1748	24	4	which	which	PRON
eurjchem-1748	24	5	is	be	AUX
eurjchem-1748	24	6	affected	affect	VERB
eurjchem-1748	24	7	by	by	ADP
eurjchem-1748	24	8	diabetes	diabetes	NOUN
eurjchem-1748	24	9	mellitus	mellitus	NOUN
eurjchem-1748	24	10	needs	need	VERB
eurjchem-1748	24	11	external	external	ADJ
eurjchem-1748	24	12	regulators	regulator	NOUN
eurjchem-1748	24	13	to	to	PART
eurjchem-1748	24	14	control	control	VERB
eurjchem-1748	24	15	the	the	DET
eurjchem-1748	24	16	insulin	insulin	NOUN
eurjchem-1748	24	17	balance	balance	NOUN
eurjchem-1748	24	18	in	in	ADP
eurjchem-1748	24	19	the	the	DET
eurjchem-1748	24	20	blood	blood	NOUN
eurjchem-1748	24	21	,	,	PUNCT
eurjchem-1748	24	22	here	here	ADV
eurjchem-1748	24	23	the	the	DET
eurjchem-1748	24	24	α	α	NOUN
eurjchem-1748	24	25	-	-	PUNCT
eurjchem-1748	24	26	glucosidase	glucosidase	ADJ
eurjchem-1748	24	27	inhibitors	inhibitor	NOUN
eurjchem-1748	24	28	come	come	VERB
eurjchem-1748	24	29	into	into	ADP
eurjchem-1748	24	30	action	action	NOUN
eurjchem-1748	24	31	,	,	PUNCT
eurjchem-1748	24	32	α	α	NOUN
eurjchem-1748	24	33	-	-	PUNCT
eurjchem-1748	24	34	glucosidase	glucosidase	ADJ
eurjchem-1748	24	35	inhibitors	inhibitor	NOUN
eurjchem-1748	24	36	decrease	decrease	VERB
eurjchem-1748	24	37	both	both	DET
eurjchem-1748	24	38	postprandial	postprandial	ADJ
eurjchem-1748	24	39	hyperglycemia	hyperglycemia	NOUN
eurjchem-1748	24	40	and	and	CCONJ
eurjchem-1748	24	41	hyperinsulinemia	hyperinsulinemia	NOUN
eurjchem-1748	24	42	,	,	PUNCT
eurjchem-1748	24	43	and	and	CCONJ
eurjchem-1748	24	44	thereby	thereby	ADV
eurjchem-1748	24	45	may	may	AUX
eurjchem-1748	24	46	improve	improve	VERB
eurjchem-1748	24	47	sensitivity	sensitivity	NOUN
eurjchem-1748	24	48	to	to	ADP
eurjchem-1748	24	49	insulin	insulin	NOUN
eurjchem-1748	24	50	and	and	CCONJ
eurjchem-1748	24	51	release	release	VERB
eurjchem-1748	24	52	the	the	DET
eurjchem-1748	24	53	stress	stress	NOUN
eurjchem-1748	24	54	on	on	ADP
eurjchem-1748	24	55	beta	beta	ADJ
eurjchem-1748	24	56	cells	cell	NOUN
eurjchem-1748	24	57	[	[	X
eurjchem-1748	24	58	7	7	NUM
eurjchem-1748	24	59	]	]	PUNCT
eurjchem-1748	24	60	.	.	PUNCT
eurjchem-1748	25	1	abstract	abstract	ADJ
eurjchem-1748	25	2	research	research	NOUN
eurjchem-1748	25	3	article	article	NOUN
eurjchem-1748	25	4	keywords	keyword	VERB
eurjchem-1748	25	5	european	european	PROPN
eurjchem-1748	25	6	journal	journal	PROPN
eurjchem-1748	25	7	of	of	ADP
eurjchem-1748	25	8	chemistry	chemistry	NOUN
eurjchem-1748	25	9	issn	issn	VERB
eurjchem-1748	25	10	2153	2153	NUM
eurjchem-1748	25	11	-	-	SYM
eurjchem-1748	25	12	2249	2249	NUM
eurjchem-1748	25	13	(	(	PUNCT
eurjchem-1748	25	14	print	print	NOUN
eurjchem-1748	25	15	)	)	PUNCT
eurjchem-1748	25	16	/	/	PUNCT
eurjchem-1748	25	17	issn	issn	PROPN
eurjchem-1748	25	18	2153	2153	NUM
eurjchem-1748	25	19	-	-	SYM
eurjchem-1748	25	20	2257	2257	NUM
eurjchem-1748	25	21	(	(	PUNCT
eurjchem-1748	25	22	online	online	ADJ
eurjchem-1748	25	23	)	)	PUNCT
eurjchem-1748	25	24	–	–	PUNCT
eurjchem-1748	26	1	copyright	copyright	NOUN
eurjchem-1748	26	2	©	©	PROPN
eurjchem-1748	26	3	2018	2018	NUM
eurjchem-1748	26	4	the	the	DET
eurjchem-1748	26	5	authors	author	NOUN
eurjchem-1748	26	6	–	–	PUNCT
eurjchem-1748	26	7	atlanta	atlanta	PROPN
eurjchem-1748	26	8	publishing	publishing	PROPN
eurjchem-1748	26	9	house	house	PROPN
eurjchem-1748	26	10	llc	llc	PROPN
eurjchem-1748	26	11	–	–	PUNCT
eurjchem-1748	26	12	printed	print	VERB
eurjchem-1748	26	13	in	in	ADP
eurjchem-1748	26	14	the	the	DET
eurjchem-1748	26	15	usa	usa	PROPN
eurjchem-1748	26	16	.	.	PUNCT
eurjchem-1748	27	1	this	this	DET
eurjchem-1748	27	2	work	work	NOUN
eurjchem-1748	27	3	is	be	AUX
eurjchem-1748	27	4	published	publish	VERB
eurjchem-1748	27	5	and	and	CCONJ
eurjchem-1748	27	6	licensed	license	VERB
eurjchem-1748	27	7	by	by	ADP
eurjchem-1748	27	8	atlanta	atlanta	PROPN
eurjchem-1748	27	9	publishing	publishing	PROPN
eurjchem-1748	27	10	house	house	PROPN
eurjchem-1748	27	11	llc	llc	PROPN
eurjchem-1748	27	12	–	–	PUNCT
eurjchem-1748	27	13	cc	cc	PROPN
eurjchem-1748	27	14	by	by	ADP
eurjchem-1748	27	15	nc	nc	PROPN
eurjchem-1748	27	16	–	–	PUNCT
eurjchem-1748	27	17	some	some	DET
eurjchem-1748	27	18	rights	right	NOUN
eurjchem-1748	27	19	reserved	reserve	VERB
eurjchem-1748	27	20	.	.	PUNCT
eurjchem-1748	28	1	http://dx.doi.org/10.5155/eurjchem.9.4.322-330.1748	http://dx.doi.org/10.5155/eurjchem.9.4.322-330.1748	NOUN
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eurjchem-1748	28	3	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.9.4.322-330.1748&domain=pdf&date_stamp=2018-12-31	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.9.4.322-330.1748&domain=pdf&date_stamp=2018-12-31	PROPN
eurjchem-1748	28	4	http://www.eurjchem.com/	http://www.eurjchem.com/	NOUN
eurjchem-1748	28	5	http://dx.doi.org/10.5155/eurjchem.9.4.322-330.1748	http://dx.doi.org/10.5155/eurjchem.9.4.322-330.1748	PROPN
eurjchem-1748	28	6	mailto:ankireddyashokreddy@gmail.com	mailto:ankireddyashokreddy@gmail.com	PROPN
eurjchem-1748	28	7	mailto:rambabu.gundla@gitam.edu	mailto:rambabu.gundla@gitam.edu	PROPN
eurjchem-1748	28	8	mailto:krishnaprasadgundla@gmail.com	mailto:krishnaprasadgundla@gmail.com	X
eurjchem-1748	29	1	mailto:balarajutuniki@gmail.com	mailto:balarajutuniki@gmail.com	PROPN
eurjchem-1748	29	2	mailto:venky.bt@gmail.com	mailto:venky.bt@gmail.com	X
eurjchem-1748	29	3	mailto:vedavathi1@gmail.com	mailto:vedavathi1@gmail.com	X
eurjchem-1748	29	4	mailto:jithendrach@gmail.com	mailto:jithendrach@gmail.com	PROPN
eurjchem-1748	29	5	mailto:rambabu.gundla@gitam.edu	mailto:rambabu.gundla@gitam.edu	PROPN
eurjchem-1748	29	6	http://www.eurjchem.com/	http://www.eurjchem.com/	NOUN
eurjchem-1748	29	7	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.9.4.322-330.1748&domain=pdf&date_stamp=2018-12-31	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.9.4.322-330.1748&domain=pdf&date_stamp=2018-12-31	PROPN
eurjchem-1748	29	8	�	�	PROPN
eurjchem-1748	29	9	ankireddy	ankireddy	PROPN
eurjchem-1748	29	10	et	et	PROPN
eurjchem-1748	29	11	al	al	PROPN
eurjchem-1748	29	12	.	.	PUNCT
eurjchem-1748	29	13	/	/	SYM
eurjchem-1748	29	14	european	european	PROPN
eurjchem-1748	29	15	journal	journal	PROPN
eurjchem-1748	29	16	of	of	ADP
eurjchem-1748	29	17	chemistry	chemistry	NOUN
eurjchem-1748	29	18	9	9	NUM
eurjchem-1748	29	19	(	(	PUNCT
eurjchem-1748	29	20	4	4	NUM
eurjchem-1748	29	21	)	)	PUNCT
eurjchem-1748	29	22	(	(	PUNCT
eurjchem-1748	29	23	2018	2018	NUM
eurjchem-1748	29	24	)	)	PUNCT
eurjchem-1748	29	25	322	322	NUM
eurjchem-1748	29	26	-	-	SYM
eurjchem-1748	29	27	330	330	NUM
eurjchem-1748	29	28	323	323	NUM
eurjchem-1748	30	1	oh	oh	INTJ
eurjchem-1748	30	2	ho	ho	PROPN
eurjchem-1748	30	3	ho	ho	PROPN
eurjchem-1748	30	4	hn	hn	PROPN
eurjchem-1748	30	5	o	o	PROPN
eurjchem-1748	30	6	ch3	ch3	PROPN
eurjchem-1748	30	7	ho	ho	PROPN
eurjchem-1748	31	1	oh	oh	INTJ
eurjchem-1748	31	2	o	o	INTJ
eurjchem-1748	32	1	o	o	INTJ
eurjchem-1748	33	1	oh	oh	INTJ
eurjchem-1748	33	2	oh	oh	INTJ
eurjchem-1748	34	1	oh	oh	INTJ
eurjchem-1748	34	2	o	o	INTJ
eurjchem-1748	35	1	o	o	X
eurjchem-1748	35	2	ho	ho	INTJ
eurjchem-1748	36	1	oh	oh	INTJ
eurjchem-1748	36	2	ho	ho	INTJ
eurjchem-1748	37	1	oh	oh	INTJ
eurjchem-1748	37	2	oh	oh	INTJ
eurjchem-1748	37	3	ho	ho	PROPN
eurjchem-1748	37	4	ho	ho	PROPN
eurjchem-1748	37	5	nh	nh	PROPN
eurjchem-1748	38	1	oh	oh	INTJ
eurjchem-1748	38	2	oh	oh	INTJ
eurjchem-1748	38	3	ho	ho	PROPN
eurjchem-1748	38	4	ho	ho	PROPN
eurjchem-1748	39	1	vogliboseacarbose	vogliboseacarbose	PROPN
eurjchem-1748	40	1	oh	oh	INTJ
eurjchem-1748	40	2	ho	ho	INTJ
eurjchem-1748	41	1	oh	oh	INTJ
eurjchem-1748	41	2	oh	oh	INTJ
eurjchem-1748	42	1	oh	oh	INTJ
eurjchem-1748	42	2	miglitol	miglitol	NOUN
eurjchem-1748	42	3	figure	figure	NOUN
eurjchem-1748	42	4	1	1	NUM
eurjchem-1748	42	5	.	.	PUNCT
eurjchem-1748	43	1	chemical	chemical	ADJ
eurjchem-1748	43	2	structure	structure	NOUN
eurjchem-1748	43	3	of	of	ADP
eurjchem-1748	43	4	sugar	sugar	NOUN
eurjchem-1748	43	5	mimics	mimic	VERB
eurjchem-1748	43	6	α	α	PRON
eurjchem-1748	43	7	-	-	PUNCT
eurjchem-1748	43	8	glucosidase	glucosidase	ADJ
eurjchem-1748	43	9	inhibitors	inhibitor	NOUN
eurjchem-1748	43	10	.	.	PUNCT
eurjchem-1748	44	1	one	one	NUM
eurjchem-1748	44	2	of	of	ADP
eurjchem-1748	44	3	the	the	DET
eurjchem-1748	44	4	strategies	strategy	NOUN
eurjchem-1748	44	5	for	for	ADP
eurjchem-1748	44	6	the	the	DET
eurjchem-1748	44	7	management	management	NOUN
eurjchem-1748	44	8	of	of	ADP
eurjchem-1748	44	9	diabetes	diabetes	NOUN
eurjchem-1748	44	10	is	be	AUX
eurjchem-1748	44	11	appropriate	appropriate	ADJ
eurjchem-1748	44	12	drug	drug	NOUN
eurjchem-1748	44	13	administration	administration	NOUN
eurjchem-1748	44	14	to	to	PART
eurjchem-1748	44	15	control	control	VERB
eurjchem-1748	44	16	postprandial	postprandial	ADJ
eurjchem-1748	44	17	hyperglycemia	hyperglycemia	NOUN
eurjchem-1748	44	18	[	[	X
eurjchem-1748	44	19	8,9	8,9	NUM
eurjchem-1748	44	20	]	]	PUNCT
eurjchem-1748	44	21	.	.	PUNCT
eurjchem-1748	45	1	many	many	ADJ
eurjchem-1748	45	2	α	α	ADJ
eurjchem-1748	45	3	-	-	ADJ
eurjchem-1748	45	4	glucosidase	glucosidase	ADJ
eurjchem-1748	45	5	inhibitors	inhibitor	NOUN
eurjchem-1748	45	6	have	have	AUX
eurjchem-1748	45	7	also	also	ADV
eurjchem-1748	45	8	been	be	AUX
eurjchem-1748	45	9	observed	observe	VERB
eurjchem-1748	45	10	as	as	ADP
eurjchem-1748	45	11	potential	potential	ADJ
eurjchem-1748	45	12	anti	anti	ADJ
eurjchem-1748	45	13	-	-	ADJ
eurjchem-1748	45	14	cancer	cancer	ADJ
eurjchem-1748	45	15	agents	agent	NOUN
eurjchem-1748	45	16	,	,	PUNCT
eurjchem-1748	45	17	antiviral	antiviral	ADJ
eurjchem-1748	45	18	infections	infection	NOUN
eurjchem-1748	45	19	,	,	PUNCT
eurjchem-1748	45	20	and	and	CCONJ
eurjchem-1748	45	21	anti	anti	ADJ
eurjchem-1748	45	22	-	-	NOUN
eurjchem-1748	45	23	proliferation	proliferation	NOUN
eurjchem-1748	45	24	in	in	ADP
eurjchem-1748	45	25	human	human	ADJ
eurjchem-1748	45	26	immunodeficiency	immunodeficiency	NOUN
eurjchem-1748	45	27	virus	virus	NOUN
eurjchem-1748	45	28	(	(	PUNCT
eurjchem-1748	45	29	hiv	hiv	PROPN
eurjchem-1748	45	30	)	)	PUNCT
eurjchem-1748	45	31	infections	infection	NOUN
eurjchem-1748	45	32	,	,	PUNCT
eurjchem-1748	45	33	making	make	VERB
eurjchem-1748	45	34	the	the	DET
eurjchem-1748	45	35	compounds	compound	NOUN
eurjchem-1748	45	36	with	with	ADP
eurjchem-1748	45	37	multiple	multiple	ADJ
eurjchem-1748	45	38	therapeutic	therapeutic	ADJ
eurjchem-1748	45	39	targets	target	NOUN
eurjchem-1748	45	40	.	.	PUNCT
eurjchem-1748	46	1	α	α	X
eurjchem-1748	46	2	-	-	PUNCT
eurjchem-1748	46	3	glucosidase	glucosidase	ADJ
eurjchem-1748	46	4	inhibitors	inhibitor	NOUN
eurjchem-1748	46	5	also	also	ADV
eurjchem-1748	46	6	have	have	VERB
eurjchem-1748	46	7	considerable	considerable	ADJ
eurjchem-1748	46	8	potential	potential	NOUN
eurjchem-1748	46	9	for	for	ADP
eurjchem-1748	46	10	preventing	prevent	VERB
eurjchem-1748	46	11	these	these	DET
eurjchem-1748	46	12	cardiovascular	cardiovascular	ADJ
eurjchem-1748	46	13	risks	risk	NOUN
eurjchem-1748	46	14	[	[	X
eurjchem-1748	46	15	10	10	NUM
eurjchem-1748	46	16	]	]	PUNCT
eurjchem-1748	46	17	.	.	PUNCT
eurjchem-1748	47	1	till	till	SCONJ
eurjchem-1748	47	2	date	date	NOUN
eurjchem-1748	47	3	,	,	PUNCT
eurjchem-1748	47	4	although	although	SCONJ
eurjchem-1748	47	5	significant	significant	ADJ
eurjchem-1748	47	6	progress	progress	NOUN
eurjchem-1748	47	7	has	have	AUX
eurjchem-1748	47	8	been	be	AUX
eurjchem-1748	47	9	made	make	VERB
eurjchem-1748	47	10	to	to	PART
eurjchem-1748	47	11	invent	invent	VERB
eurjchem-1748	47	12	new	new	ADJ
eurjchem-1748	47	13	class	class	NOUN
eurjchem-1748	47	14	of	of	ADP
eurjchem-1748	47	15	α	α	NOUN
eurjchem-1748	47	16	-	-	ADJ
eurjchem-1748	47	17	glucosidase	glucosidase	ADJ
eurjchem-1748	47	18	inhibitors	inhibitor	NOUN
eurjchem-1748	47	19	for	for	ADP
eurjchem-1748	47	20	the	the	DET
eurjchem-1748	47	21	treatment	treatment	NOUN
eurjchem-1748	47	22	of	of	ADP
eurjchem-1748	47	23	diabetes	diabetes	NOUN
eurjchem-1748	47	24	[	[	X
eurjchem-1748	47	25	11	11	NUM
eurjchem-1748	47	26	-	-	SYM
eurjchem-1748	47	27	15	15	NUM
eurjchem-1748	47	28	]	]	X
eurjchem-1748	47	29	most	most	ADJ
eurjchem-1748	47	30	of	of	ADP
eurjchem-1748	47	31	the	the	DET
eurjchem-1748	47	32	developed	develop	VERB
eurjchem-1748	47	33	ones	one	NOUN
eurjchem-1748	47	34	are	be	AUX
eurjchem-1748	47	35	sugar	sugar	NOUN
eurjchem-1748	47	36	mimics	mimic	NOUN
eurjchem-1748	47	37	(	(	PUNCT
eurjchem-1748	47	38	figure	figure	NOUN
eurjchem-1748	47	39	1	1	NUM
eurjchem-1748	47	40	)	)	PUNCT
eurjchem-1748	47	41	which	which	PRON
eurjchem-1748	47	42	require	require	VERB
eurjchem-1748	47	43	tedious	tedious	ADJ
eurjchem-1748	47	44	chemical	chemical	NOUN
eurjchem-1748	47	45	procedures	procedure	NOUN
eurjchem-1748	47	46	[	[	X
eurjchem-1748	47	47	16	16	NUM
eurjchem-1748	47	48	]	]	PUNCT
eurjchem-1748	47	49	,	,	PUNCT
eurjchem-1748	47	50	low	low	ADJ
eurjchem-1748	47	51	yield	yield	NOUN
eurjchem-1748	47	52	,	,	PUNCT
eurjchem-1748	47	53	long	long	ADJ
eurjchem-1748	47	54	reaction	reaction	NOUN
eurjchem-1748	47	55	conditions	condition	NOUN
eurjchem-1748	47	56	and	and	CCONJ
eurjchem-1748	47	57	high	high	ADJ
eurjchem-1748	47	58	temperature	temperature	NOUN
eurjchem-1748	47	59	reactions	reaction	NOUN
eurjchem-1748	47	60	.	.	PUNCT
eurjchem-1748	48	1	at	at	ADP
eurjchem-1748	48	2	present	present	ADJ
eurjchem-1748	48	3	,	,	PUNCT
eurjchem-1748	48	4	a	a	DET
eurjchem-1748	48	5	large	large	ADJ
eurjchem-1748	48	6	number	number	NOUN
eurjchem-1748	48	7	of	of	ADP
eurjchem-1748	48	8	compounds	compound	NOUN
eurjchem-1748	48	9	mimicking	mimic	VERB
eurjchem-1748	48	10	the	the	DET
eurjchem-1748	48	11	structures	structure	NOUN
eurjchem-1748	48	12	of	of	ADP
eurjchem-1748	48	13	monosaccharides	monosaccharide	NOUN
eurjchem-1748	48	14	or	or	CCONJ
eurjchem-1748	48	15	oligosaccharides	oligosaccharide	NOUN
eurjchem-1748	48	16	have	have	AUX
eurjchem-1748	48	17	been	be	AUX
eurjchem-1748	48	18	discovered	discover	VERB
eurjchem-1748	48	19	from	from	ADP
eurjchem-1748	48	20	natural	natural	ADJ
eurjchem-1748	48	21	sources	source	NOUN
eurjchem-1748	48	22	,	,	PUNCT
eurjchem-1748	48	23	which	which	PRON
eurjchem-1748	48	24	include	include	VERB
eurjchem-1748	48	25	thiosugars	thiosugar	NOUN
eurjchem-1748	48	26	[	[	X
eurjchem-1748	48	27	17	17	NUM
eurjchem-1748	48	28	-	-	SYM
eurjchem-1748	48	29	19	19	NUM
eurjchem-1748	48	30	]	]	PUNCT
eurjchem-1748	48	31	,	,	PUNCT
eurjchem-1748	48	32	nitrogen	nitrogen	NOUN
eurjchem-1748	48	33	containing	contain	VERB
eurjchem-1748	48	34	α	α	NOUN
eurjchem-1748	48	35	-	-	ADJ
eurjchem-1748	48	36	glucosidase	glucosidase	ADJ
eurjchem-1748	48	37	inhibitors	inhibitor	NOUN
eurjchem-1748	48	38	[	[	X
eurjchem-1748	48	39	20	20	NUM
eurjchem-1748	48	40	]	]	PUNCT
eurjchem-1748	48	41	.	.	PUNCT
eurjchem-1748	49	1	among	among	ADP
eurjchem-1748	49	2	the	the	DET
eurjchem-1748	49	3	multifarious	multifarious	ADJ
eurjchem-1748	49	4	biologically	biologically	ADV
eurjchem-1748	49	5	active	active	ADJ
eurjchem-1748	49	6	heterocyclic	heterocyclic	ADJ
eurjchem-1748	49	7	compounds	compound	NOUN
eurjchem-1748	49	8	,	,	PUNCT
eurjchem-1748	49	9	nitrogen	nitrogen	NOUN
eurjchem-1748	49	10	containing	contain	VERB
eurjchem-1748	49	11	heterocycles	heterocycle	NOUN
eurjchem-1748	49	12	play	play	VERB
eurjchem-1748	49	13	a	a	DET
eurjchem-1748	49	14	vital	vital	ADJ
eurjchem-1748	49	15	role	role	NOUN
eurjchem-1748	49	16	in	in	ADP
eurjchem-1748	49	17	controlling	control	VERB
eurjchem-1748	49	18	postprandial	postprandial	ADJ
eurjchem-1748	49	19	glucose	glucose	NOUN
eurjchem-1748	49	20	[	[	X
eurjchem-1748	49	21	21	21	NUM
eurjchem-1748	49	22	]	]	PUNCT
eurjchem-1748	49	23	.	.	PUNCT
eurjchem-1748	50	1	in	in	ADP
eurjchem-1748	50	2	fact	fact	NOUN
eurjchem-1748	50	3	,	,	PUNCT
eurjchem-1748	50	4	recent	recent	ADJ
eurjchem-1748	50	5	surveys	survey	NOUN
eurjchem-1748	50	6	have	have	AUX
eurjchem-1748	50	7	reported	report	VERB
eurjchem-1748	50	8	that	that	SCONJ
eurjchem-1748	50	9	a	a	DET
eurjchem-1748	50	10	high	high	ADJ
eurjchem-1748	50	11	number	number	NOUN
eurjchem-1748	50	12	of	of	ADP
eurjchem-1748	50	13	molecules	molecule	NOUN
eurjchem-1748	50	14	currently	currently	ADV
eurjchem-1748	50	15	under	under	ADP
eurjchem-1748	50	16	scrutiny	scrutiny	NOUN
eurjchem-1748	50	17	by	by	ADP
eurjchem-1748	50	18	researchers	researcher	NOUN
eurjchem-1748	50	19	,	,	PUNCT
eurjchem-1748	50	20	which	which	PRON
eurjchem-1748	50	21	contain	contain	VERB
eurjchem-1748	50	22	nitrogen	nitrogen	NOUN
eurjchem-1748	50	23	containing	contain	VERB
eurjchem-1748	50	24	heterocyclic	heterocyclic	ADJ
eurjchem-1748	50	25	chemical	chemical	NOUN
eurjchem-1748	50	26	compounds	compound	NOUN
eurjchem-1748	50	27	,	,	PUNCT
eurjchem-1748	50	28	from	from	ADP
eurjchem-1748	50	29	those	those	PRON
eurjchem-1748	50	30	,	,	PUNCT
eurjchem-1748	50	31	quinazoline	quinazoline	NOUN
eurjchem-1748	50	32	and	and	CCONJ
eurjchem-1748	50	33	quinazolinone	quinazolinone	NOUN
eurjchem-1748	50	34	derivatives	derivative	NOUN
eurjchem-1748	50	35	are	be	AUX
eurjchem-1748	50	36	found	find	VERB
eurjchem-1748	50	37	at	at	ADP
eurjchem-1748	50	38	most	most	ADV
eurjchem-1748	50	39	important	important	ADJ
eurjchem-1748	50	40	family	family	NOUN
eurjchem-1748	50	41	of	of	ADP
eurjchem-1748	50	42	compounds	compound	NOUN
eurjchem-1748	50	43	[	[	PUNCT
eurjchem-1748	50	44	22	22	NUM
eurjchem-1748	50	45	-	-	SYM
eurjchem-1748	50	46	24	24	NUM
eurjchem-1748	50	47	]	]	PUNCT
eurjchem-1748	50	48	.	.	PUNCT
eurjchem-1748	51	1	the	the	DET
eurjchem-1748	51	2	synthesized	synthesize	VERB
eurjchem-1748	51	3	compounds	compound	NOUN
eurjchem-1748	51	4	(	(	PUNCT
eurjchem-1748	51	5	quinazolines	quinazoline	NOUN
eurjchem-1748	51	6	)	)	PUNCT
eurjchem-1748	51	7	have	have	VERB
eurjchem-1748	51	8	a	a	DET
eurjchem-1748	51	9	common	common	ADJ
eurjchem-1748	51	10	unique	unique	ADJ
eurjchem-1748	51	11	structural	structural	ADJ
eurjchem-1748	51	12	framework	framework	NOUN
eurjchem-1748	51	13	,	,	PUNCT
eurjchem-1748	51	14	which	which	PRON
eurjchem-1748	51	15	we	we	PRON
eurjchem-1748	51	16	were	be	AUX
eurjchem-1748	51	17	able	able	ADJ
eurjchem-1748	51	18	to	to	PART
eurjchem-1748	51	19	use	use	VERB
eurjchem-1748	51	20	for	for	ADP
eurjchem-1748	51	21	the	the	DET
eurjchem-1748	51	22	scaffold	scaffold	NOUN
eurjchem-1748	51	23	diversification	diversification	NOUN
eurjchem-1748	51	24	,	,	PUNCT
eurjchem-1748	51	25	which	which	PRON
eurjchem-1748	51	26	is	be	AUX
eurjchem-1748	51	27	useful	useful	ADJ
eurjchem-1748	51	28	for	for	ADP
eurjchem-1748	51	29	the	the	DET
eurjchem-1748	51	30	preparation	preparation	NOUN
eurjchem-1748	51	31	of	of	ADP
eurjchem-1748	51	32	pharmacological	pharmacological	ADJ
eurjchem-1748	51	33	entities	entity	NOUN
eurjchem-1748	51	34	[	[	X
eurjchem-1748	51	35	25	25	NUM
eurjchem-1748	51	36	]	]	PUNCT
eurjchem-1748	51	37	.	.	PUNCT
eurjchem-1748	52	1	so	so	ADV
eurjchem-1748	52	2	far	far	ADV
eurjchem-1748	52	3	,	,	PUNCT
eurjchem-1748	52	4	in	in	ADP
eurjchem-1748	52	5	the	the	DET
eurjchem-1748	52	6	literature	literature	NOUN
eurjchem-1748	52	7	,	,	PUNCT
eurjchem-1748	52	8	research	research	NOUN
eurjchem-1748	52	9	on	on	ADP
eurjchem-1748	52	10	quinazolin-4(3h)-ones	quinazolin-4(3h)-one	NOUN
eurjchem-1748	52	11	have	have	AUX
eurjchem-1748	52	12	been	be	AUX
eurjchem-1748	52	13	carried	carry	VERB
eurjchem-1748	52	14	out	out	ADP
eurjchem-1748	52	15	on	on	ADP
eurjchem-1748	52	16	the	the	DET
eurjchem-1748	52	17	c-2	c-2	NOUN
eurjchem-1748	52	18	,	,	PUNCT
eurjchem-1748	52	19	n3	n3	NOUN
eurjchem-1748	52	20	,	,	PUNCT
eurjchem-1748	52	21	c-4	c-4	NOUN
eurjchem-1748	52	22	and	and	CCONJ
eurjchem-1748	52	23	c-6	c-6	NOUN
eurjchem-1748	52	24	positions	position	NOUN
eurjchem-1748	52	25	of	of	ADP
eurjchem-1748	52	26	the	the	DET
eurjchem-1748	52	27	core	core	NOUN
eurjchem-1748	52	28	structure	structure	NOUN
eurjchem-1748	52	29	[	[	X
eurjchem-1748	52	30	26	26	NUM
eurjchem-1748	52	31	]	]	PUNCT
eurjchem-1748	52	32	.	.	PUNCT
eurjchem-1748	53	1	a	a	DET
eurjchem-1748	53	2	very	very	ADV
eurjchem-1748	53	3	few	few	ADJ
eurjchem-1748	53	4	literature	literature	NOUN
eurjchem-1748	53	5	evidences	evidence	NOUN
eurjchem-1748	53	6	have	have	AUX
eurjchem-1748	53	7	been	be	AUX
eurjchem-1748	53	8	studied	study	VERB
eurjchem-1748	53	9	on	on	ADP
eurjchem-1748	53	10	the	the	DET
eurjchem-1748	53	11	extension	extension	NOUN
eurjchem-1748	53	12	of	of	ADP
eurjchem-1748	53	13	c-7	c-7	NOUN
eurjchem-1748	53	14	position	position	NOUN
eurjchem-1748	53	15	of	of	ADP
eurjchem-1748	53	16	the	the	DET
eurjchem-1748	53	17	core	core	NOUN
eurjchem-1748	53	18	structure	structure	NOUN
eurjchem-1748	53	19	[	[	X
eurjchem-1748	53	20	20,27,28	20,27,28	NOUN
eurjchem-1748	53	21	]	]	X
eurjchem-1748	53	22	.	.	PUNCT
eurjchem-1748	54	1	therefore	therefore	ADV
eurjchem-1748	54	2	,	,	PUNCT
eurjchem-1748	54	3	there	there	PRON
eurjchem-1748	54	4	is	be	VERB
eurjchem-1748	54	5	a	a	DET
eurjchem-1748	54	6	substantial	substantial	ADJ
eurjchem-1748	54	7	enthusiasm	enthusiasm	NOUN
eurjchem-1748	54	8	in	in	ADP
eurjchem-1748	54	9	developing	develop	VERB
eurjchem-1748	54	10	efficient	efficient	ADJ
eurjchem-1748	54	11	methods	method	NOUN
eurjchem-1748	54	12	for	for	ADP
eurjchem-1748	54	13	the	the	DET
eurjchem-1748	54	14	synthesis	synthesis	NOUN
eurjchem-1748	54	15	of	of	ADP
eurjchem-1748	54	16	c-7substituted-2	c-7substituted-2	NOUN
eurjchem-1748	54	17	-	-	PUNCT
eurjchem-1748	54	18	morpholino	morpholino	NOUN
eurjchem-1748	54	19	-	-	PUNCT
eurjchem-1748	54	20	n-(pyridin-2	n-(pyridin-2	NUM
eurjchem-1748	54	21	-	-	PUNCT
eurjchem-1748	54	22	ylmet	ylmet	NOUN
eurjchem-1748	54	23	hyl)quinazolin-4	hyl)quinazolin-4	NOUN
eurjchem-1748	54	24	-	-	NOUN
eurjchem-1748	54	25	amine	amine	NOUN
eurjchem-1748	54	26	.	.	PUNCT
eurjchem-1748	55	1	recently	recently	ADV
eurjchem-1748	55	2	,	,	PUNCT
eurjchem-1748	55	3	we	we	PRON
eurjchem-1748	55	4	published	publish	VERB
eurjchem-1748	55	5	few	few	ADJ
eurjchem-1748	55	6	proficient	proficient	ADJ
eurjchem-1748	55	7	palladium	palladium	NOUN
eurjchem-1748	55	8	catalysed	catalyse	VERB
eurjchem-1748	55	9	synthetic	synthetic	ADJ
eurjchem-1748	55	10	method	method	NOUN
eurjchem-1748	55	11	for	for	ADP
eurjchem-1748	55	12	the	the	DET
eurjchem-1748	55	13	introduction	introduction	NOUN
eurjchem-1748	55	14	of	of	ADP
eurjchem-1748	55	15	substituted	substitute	VERB
eurjchem-1748	55	16	amino	amino	NOUN
eurjchem-1748	55	17	groups	group	NOUN
eurjchem-1748	55	18	at	at	ADP
eurjchem-1748	55	19	the	the	DET
eurjchem-1748	55	20	c-6	c-6	NOUN
eurjchem-1748	55	21	position	position	NOUN
eurjchem-1748	55	22	of	of	ADP
eurjchem-1748	55	23	2	2	NUM
eurjchem-1748	55	24	-	-	PUNCT
eurjchem-1748	55	25	cyclopropyl3-(pyridyl-3ylmethyl)quinazolin-4(3h)-one	cyclopropyl3-(pyridyl-3ylmethyl)quinazolin-4(3h)-one	NOUN
eurjchem-1748	55	26	with	with	ADP
eurjchem-1748	55	27	impressive	impressive	ADJ
eurjchem-1748	55	28	yields	yield	NOUN
eurjchem-1748	55	29	.	.	PUNCT
eurjchem-1748	56	1	these	these	DET
eurjchem-1748	56	2	scaffolds	scaffold	NOUN
eurjchem-1748	56	3	further	far	ADV
eurjchem-1748	56	4	modified	modify	VERB
eurjchem-1748	56	5	at	at	ADP
eurjchem-1748	56	6	c-4	c-4	NOUN
eurjchem-1748	56	7	position	position	NOUN
eurjchem-1748	56	8	using	use	VERB
eurjchem-1748	56	9	amidation	amidation	NOUN
eurjchem-1748	56	10	[	[	X
eurjchem-1748	56	11	23	23	NUM
eurjchem-1748	56	12	]	]	PUNCT
eurjchem-1748	56	13	.	.	PUNCT
eurjchem-1748	57	1	here	here	ADV
eurjchem-1748	57	2	in	in	ADP
eurjchem-1748	57	3	this	this	DET
eurjchem-1748	57	4	article	article	NOUN
eurjchem-1748	57	5	,	,	PUNCT
eurjchem-1748	57	6	we	we	PRON
eurjchem-1748	57	7	report	report	VERB
eurjchem-1748	57	8	a	a	DET
eurjchem-1748	57	9	lead	lead	NOUN
eurjchem-1748	57	10	α	α	NOUN
eurjchem-1748	57	11	-	-	ADJ
eurjchem-1748	57	12	glucosidase	glucosidase	ADJ
eurjchem-1748	57	13	inhibitor	inhibitor	NOUN
eurjchem-1748	57	14	from	from	ADP
eurjchem-1748	57	15	a	a	DET
eurjchem-1748	57	16	series	series	NOUN
eurjchem-1748	57	17	of	of	ADP
eurjchem-1748	57	18	20	20	NUM
eurjchem-1748	57	19	novel	novel	ADJ
eurjchem-1748	57	20	quinazoline	quinazoline	NOUN
eurjchem-1748	57	21	derivatives	derivative	NOUN
eurjchem-1748	57	22	.	.	PUNCT
eurjchem-1748	58	1	the	the	DET
eurjchem-1748	58	2	binding	bind	VERB
eurjchem-1748	58	3	mode	mode	NOUN
eurjchem-1748	58	4	of	of	ADP
eurjchem-1748	58	5	the	the	DET
eurjchem-1748	58	6	compounds	compound	NOUN
eurjchem-1748	58	7	and	and	CCONJ
eurjchem-1748	58	8	all	all	DET
eurjchem-1748	58	9	molecules	molecule	NOUN
eurjchem-1748	58	10	(	(	PUNCT
eurjchem-1748	58	11	sar	sar	PROPN
eurjchem-1748	58	12	)	)	PUNCT
eurjchem-1748	58	13	including	include	VERB
eurjchem-1748	58	14	reference	reference	NOUN
eurjchem-1748	58	15	compound	compound	NOUN
eurjchem-1748	58	16	acarbose	acarbose	NOUN
eurjchem-1748	58	17	at	at	ADP
eurjchem-1748	58	18	the	the	DET
eurjchem-1748	58	19	active	active	ADJ
eurjchem-1748	58	20	site	site	NOUN
eurjchem-1748	58	21	of	of	ADP
eurjchem-1748	58	22	alpha	alpha	NOUN
eurjchem-1748	58	23	-	-	PUNCT
eurjchem-1748	58	24	glucosidase	glucosidase	PROPN
eurjchem-1748	58	25	was	be	AUX
eurjchem-1748	58	26	explored	explore	VERB
eurjchem-1748	58	27	using	use	VERB
eurjchem-1748	58	28	glide	glide	NOUN
eurjchem-1748	59	1	[	[	X
eurjchem-1748	59	2	26	26	NUM
eurjchem-1748	59	3	]	]	PUNCT
eurjchem-1748	59	4	also	also	ADV
eurjchem-1748	59	5	here	here	ADV
eurjchem-1748	59	6	we	we	PRON
eurjchem-1748	59	7	report	report	VERB
eurjchem-1748	59	8	drug	drug	NOUN
eurjchem-1748	59	9	-	-	PUNCT
eurjchem-1748	59	10	like	like	ADJ
eurjchem-1748	59	11	properties	property	NOUN
eurjchem-1748	59	12	of	of	ADP
eurjchem-1748	59	13	the	the	DET
eurjchem-1748	59	14	all	all	DET
eurjchem-1748	59	15	chemical	chemical	ADJ
eurjchem-1748	59	16	entities	entity	NOUN
eurjchem-1748	59	17	by	by	ADP
eurjchem-1748	59	18	in	in	ADP
eurjchem-1748	59	19	-	-	PUNCT
eurjchem-1748	59	20	silico	silico	NOUN
eurjchem-1748	59	21	experiments	experiment	NOUN
eurjchem-1748	59	22	.	.	PUNCT
eurjchem-1748	60	1	2	2	X
eurjchem-1748	60	2	.	.	X
eurjchem-1748	60	3	experimental	experimental	ADJ
eurjchem-1748	60	4	2.1	2.1	NUM
eurjchem-1748	60	5	.	.	PUNCT
eurjchem-1748	60	6	synthesis	synthesis	NOUN
eurjchem-1748	60	7	for	for	ADP
eurjchem-1748	60	8	the	the	DET
eurjchem-1748	60	9	present	present	ADJ
eurjchem-1748	60	10	work	work	NOUN
eurjchem-1748	60	11	,	,	PUNCT
eurjchem-1748	60	12	7	7	NUM
eurjchem-1748	60	13	-	-	PUNCT
eurjchem-1748	60	14	chloro-2	chloro-2	NUM
eurjchem-1748	60	15	-	-	PUNCT
eurjchem-1748	60	16	morpholino	morpholino	NOUN
eurjchem-1748	60	17	-	-	PUNCT
eurjchem-1748	60	18	n-(pyridin2	n-(pyridin2	NOUN
eurjchem-1748	60	19	-	-	PUNCT
eurjchem-1748	60	20	ylmethyl)quinazolin-4	ylmethyl)quinazolin-4	NUM
eurjchem-1748	60	21	-	-	PUNCT
eurjchem-1748	60	22	amine	amine	NOUN
eurjchem-1748	60	23	synthesized	synthesize	VERB
eurjchem-1748	60	24	intermediate	intermediate	ADJ
eurjchem-1748	60	25	7	7	NUM
eurjchem-1748	60	26	was	be	AUX
eurjchem-1748	60	27	chosen	choose	VERB
eurjchem-1748	60	28	as	as	ADP
eurjchem-1748	60	29	a	a	DET
eurjchem-1748	60	30	key	key	ADJ
eurjchem-1748	60	31	starting	starting	NOUN
eurjchem-1748	60	32	material	material	NOUN
eurjchem-1748	60	33	for	for	ADP
eurjchem-1748	60	34	the	the	DET
eurjchem-1748	60	35	study	study	NOUN
eurjchem-1748	60	36	,	,	PUNCT
eurjchem-1748	60	37	and	and	CCONJ
eurjchem-1748	60	38	the	the	DET
eurjchem-1748	60	39	first	first	ADJ
eurjchem-1748	60	40	two	two	NUM
eurjchem-1748	60	41	steps	step	NOUN
eurjchem-1748	60	42	were	be	AUX
eurjchem-1748	60	43	conveniently	conveniently	ADV
eurjchem-1748	60	44	synthesized	synthesize	VERB
eurjchem-1748	60	45	by	by	ADP
eurjchem-1748	60	46	known	know	VERB
eurjchem-1748	60	47	procedures	procedure	NOUN
eurjchem-1748	60	48	[	[	X
eurjchem-1748	60	49	2	2	NUM
eurjchem-1748	60	50	]	]	PUNCT
eurjchem-1748	60	51	.	.	PUNCT
eurjchem-1748	61	1	the	the	DET
eurjchem-1748	61	2	compound	compound	NOUN
eurjchem-1748	61	3	2,4,7	2,4,7	NOUN
eurjchem-1748	61	4	-	-	PUNCT
eurjchem-1748	61	5	trichloroquinazoline	trichloroquinazoline	NOUN
eurjchem-1748	61	6	(	(	PUNCT
eurjchem-1748	61	7	compound	compound	NOUN
eurjchem-1748	61	8	3	3	NUM
eurjchem-1748	61	9	)	)	PUNCT
eurjchem-1748	61	10	was	be	AUX
eurjchem-1748	61	11	synthesized	synthesize	VERB
eurjchem-1748	61	12	by	by	ADP
eurjchem-1748	61	13	cyclisation	cyclisation	NOUN
eurjchem-1748	61	14	with	with	ADP
eurjchem-1748	61	15	2	2	NUM
eurjchem-1748	61	16	-	-	PUNCT
eurjchem-1748	61	17	amino-4chlorobenzoic	amino-4chlorobenzoic	PROPN
eurjchem-1748	61	18	acid	acid	NOUN
eurjchem-1748	61	19	with	with	ADP
eurjchem-1748	61	20	urea	urea	NOUN
eurjchem-1748	61	21	at	at	ADP
eurjchem-1748	61	22	neat	neat	ADJ
eurjchem-1748	61	23	,	,	PUNCT
eurjchem-1748	61	24	200	200	NUM
eurjchem-1748	61	25	°	°	NOUN
eurjchem-1748	61	26	c	c	NOUN
eurjchem-1748	61	27	,	,	PUNCT
eurjchem-1748	61	28	8	8	NUM
eurjchem-1748	61	29	h	h	NOUN
eurjchem-1748	61	30	,	,	PUNCT
eurjchem-1748	61	31	the	the	DET
eurjchem-1748	61	32	reaction	reaction	NOUN
eurjchem-1748	61	33	mixture	mixture	NOUN
eurjchem-1748	61	34	was	be	AUX
eurjchem-1748	61	35	diluted	dilute	VERB
eurjchem-1748	61	36	with	with	ADP
eurjchem-1748	61	37	water	water	NOUN
eurjchem-1748	61	38	,	,	PUNCT
eurjchem-1748	61	39	filtered	filter	VERB
eurjchem-1748	61	40	and	and	CCONJ
eurjchem-1748	61	41	dried	dry	VERB
eurjchem-1748	61	42	to	to	PART
eurjchem-1748	61	43	give	give	VERB
eurjchem-1748	61	44	7chloroquinazoline-2,4(1h,3h)-dione	7chloroquinazoline-2,4(1h,3h)-dione	NUM
eurjchem-1748	61	45	(	(	PUNCT
eurjchem-1748	61	46	compound	compound	NOUN
eurjchem-1748	61	47	2	2	NUM
eurjchem-1748	61	48	)	)	PUNCT
eurjchem-1748	61	49	.	.	PUNCT
eurjchem-1748	62	1	the	the	DET
eurjchem-1748	62	2	obtained	obtain	VERB
eurjchem-1748	62	3	compound	compound	NOUN
eurjchem-1748	62	4	2	2	NUM
eurjchem-1748	62	5	was	be	AUX
eurjchem-1748	62	6	chlorinated	chlorinate	VERB
eurjchem-1748	62	7	with	with	ADP
eurjchem-1748	62	8	pocl3	pocl3	PROPN
eurjchem-1748	62	9	,	,	PUNCT
eurjchem-1748	62	10	n	n	CCONJ
eurjchem-1748	62	11	,	,	PUNCT
eurjchem-1748	62	12	n	n	CCONJ
eurjchem-1748	62	13	-	-	PUNCT
eurjchem-1748	62	14	dimethylaniline	dimethylaniline	NOUN
eurjchem-1748	62	15	,	,	PUNCT
eurjchem-1748	62	16	reflux	reflux	VERB
eurjchem-1748	62	17	for	for	ADP
eurjchem-1748	62	18	8	8	NUM
eurjchem-1748	62	19	h	h	NOUN
eurjchem-1748	62	20	,	,	PUNCT
eurjchem-1748	62	21	and	and	CCONJ
eurjchem-1748	62	22	then	then	ADV
eurjchem-1748	62	23	allowed	allow	VERB
eurjchem-1748	62	24	to	to	PART
eurjchem-1748	62	25	cool	cool	VERB
eurjchem-1748	62	26	to	to	PART
eurjchem-1748	62	27	room	room	VERB
eurjchem-1748	62	28	temperature	temperature	NOUN
eurjchem-1748	62	29	and	and	CCONJ
eurjchem-1748	62	30	poured	pour	VERB
eurjchem-1748	62	31	in	in	ADP
eurjchem-1748	62	32	to	to	ADP
eurjchem-1748	62	33	ice	ice	NOUN
eurjchem-1748	62	34	cold	cold	ADJ
eurjchem-1748	62	35	water	water	NOUN
eurjchem-1748	62	36	.	.	PUNCT
eurjchem-1748	63	1	the	the	DET
eurjchem-1748	63	2	resulting	result	VERB
eurjchem-1748	63	3	solid	solid	NOUN
eurjchem-1748	63	4	was	be	AUX
eurjchem-1748	63	5	collected	collect	VERB
eurjchem-1748	63	6	by	by	ADP
eurjchem-1748	63	7	filtration	filtration	NOUN
eurjchem-1748	63	8	and	and	CCONJ
eurjchem-1748	63	9	dried	dry	VERB
eurjchem-1748	63	10	to	to	PART
eurjchem-1748	63	11	give	give	VERB
eurjchem-1748	63	12	pure	pure	ADJ
eurjchem-1748	63	13	2,4,7	2,4,7	PROPN
eurjchem-1748	63	14	-	-	PUNCT
eurjchem-1748	63	15	trichloroquinazoline	trichloroquinazoline	NOUN
eurjchem-1748	63	16	(	(	PUNCT
eurjchem-1748	63	17	compound	compound	NOUN
eurjchem-1748	63	18	3	3	NUM
eurjchem-1748	63	19	)	)	PUNCT
eurjchem-1748	63	20	.	.	PUNCT
eurjchem-1748	64	1	to	to	ADP
eurjchem-1748	64	2	the	the	DET
eurjchem-1748	64	3	solution	solution	NOUN
eurjchem-1748	64	4	of	of	ADP
eurjchem-1748	64	5	2,4,7	2,4,7	PROPN
eurjchem-1748	64	6	-	-	PUNCT
eurjchem-1748	64	7	trichloroquinazoline	trichloroquinazoline	NOUN
eurjchem-1748	64	8	(	(	PUNCT
eurjchem-1748	64	9	compound	compound	NOUN
eurjchem-1748	64	10	3	3	NUM
eurjchem-1748	64	11	)	)	PUNCT
eurjchem-1748	64	12	in	in	ADP
eurjchem-1748	64	13	thf	thf	NOUN
eurjchem-1748	64	14	was	be	AUX
eurjchem-1748	64	15	added	add	VERB
eurjchem-1748	64	16	pyridin-2	pyridin-2	NOUN
eurjchem-1748	64	17	-	-	PUNCT
eurjchem-1748	64	18	ylmethanamine	ylmethanamine	NOUN
eurjchem-1748	64	19	,	,	PUNCT
eurjchem-1748	64	20	stirred	stir	VERB
eurjchem-1748	64	21	at	at	ADP
eurjchem-1748	64	22	room	room	NOUN
eurjchem-1748	64	23	temperature	temperature	NOUN
eurjchem-1748	64	24	for	for	ADP
eurjchem-1748	64	25	12	12	NUM
eurjchem-1748	64	26	h	h	NOUN
eurjchem-1748	64	27	to	to	PART
eurjchem-1748	64	28	give	give	VERB
eurjchem-1748	64	29	the	the	DET
eurjchem-1748	64	30	2,7	2,7	NUM
eurjchem-1748	64	31	-	-	PUNCT
eurjchem-1748	64	32	dichloro	dichloro	NOUN
eurjchem-1748	64	33	-	-	PUNCT
eurjchem-1748	64	34	n-(pyridin-2	n-(pyridin-2	NUM
eurjchem-1748	64	35	-	-	PUNCT
eurjchem-1748	64	36	ylmethyl)quinazolin-4amine	ylmethyl)quinazolin-4amine	NOUN
eurjchem-1748	64	37	(	(	PUNCT
eurjchem-1748	64	38	compound	compound	NOUN
eurjchem-1748	64	39	5	5	NUM
eurjchem-1748	64	40	)	)	PUNCT
eurjchem-1748	64	41	,	,	PUNCT
eurjchem-1748	64	42	followed	follow	VERB
eurjchem-1748	64	43	by	by	ADP
eurjchem-1748	64	44	the	the	DET
eurjchem-1748	64	45	reaction	reaction	NOUN
eurjchem-1748	64	46	with	with	ADP
eurjchem-1748	64	47	morpholine	morpholine	NOUN
eurjchem-1748	64	48	in	in	ADP
eurjchem-1748	64	49	isopropyl	isopropyl	NOUN
eurjchem-1748	64	50	alcohol	alcohol	PROPN
eurjchem-1748	64	51	,	,	PUNCT
eurjchem-1748	64	52	dipea	dipea	NOUN
eurjchem-1748	64	53	stirred	stir	VERB
eurjchem-1748	64	54	at	at	ADP
eurjchem-1748	64	55	100	100	NUM
eurjchem-1748	64	56	°	°	ADP
eurjchem-1748	64	57	c	c	NOUN
eurjchem-1748	64	58	for	for	ADP
eurjchem-1748	64	59	12	12	NUM
eurjchem-1748	64	60	h.	h.	NOUN
eurjchem-1748	64	61	the	the	DET
eurjchem-1748	64	62	crude	crude	ADJ
eurjchem-1748	64	63	compound	compound	NOUN
eurjchem-1748	64	64	was	be	AUX
eurjchem-1748	64	65	purified	purify	VERB
eurjchem-1748	64	66	by	by	ADP
eurjchem-1748	64	67	combi	combi	PROPN
eurjchem-1748	64	68	flash	flash	PROPN
eurjchem-1748	64	69	chromatography	chromatography	NOUN
eurjchem-1748	64	70	to	to	PART
eurjchem-1748	64	71	give	give	VERB
eurjchem-1748	64	72	pure	pure	ADJ
eurjchem-1748	64	73	7	7	NUM
eurjchem-1748	64	74	-	-	PUNCT
eurjchem-1748	64	75	chloro-2	chloro-2	VERB
eurjchem-1748	64	76	-	-	PUNCT
eurjchem-1748	64	77	morpholino	morpholino	NOUN
eurjchem-1748	64	78	-	-	PUNCT
eurjchem-1748	64	79	n-(pyridin-2	n-(pyridin-2	NOUN
eurjchem-1748	64	80	-	-	PUNCT
eurjchem-1748	64	81	ylmethyl	ylmethyl	NOUN
eurjchem-1748	64	82	)	)	PUNCT
eurjchem-1748	64	83	quinazolin-4	quinazolin-4	NOUN
eurjchem-1748	64	84	-	-	NOUN
eurjchem-1748	64	85	amine	amine	ADJ
eurjchem-1748	64	86	(	(	PUNCT
eurjchem-1748	64	87	compound	compound	NOUN
eurjchem-1748	64	88	7	7	NUM
eurjchem-1748	64	89	)	)	PUNCT
eurjchem-1748	64	90	(	(	PUNCT
eurjchem-1748	64	91	scheme	scheme	NOUN
eurjchem-1748	64	92	1	1	NUM
eurjchem-1748	64	93	)	)	PUNCT
eurjchem-1748	64	94	.	.	PUNCT
eurjchem-1748	65	1	compound	compound	NOUN
eurjchem-1748	65	2	7	7	NUM
eurjchem-1748	65	3	was	be	AUX
eurjchem-1748	65	4	modified	modify	VERB
eurjchem-1748	65	5	at	at	ADP
eurjchem-1748	65	6	c-7	c-7	NOUN
eurjchem-1748	65	7	position	position	NOUN
eurjchem-1748	65	8	by	by	ADP
eurjchem-1748	65	9	utilizing	utilize	VERB
eurjchem-1748	65	10	suzuki	suzuki	NOUN
eurjchem-1748	65	11	-	-	PUNCT
eurjchem-1748	65	12	miyaura	miyaura	NOUN
eurjchem-1748	65	13	cross	cross	ADJ
eurjchem-1748	65	14	-	-	ADJ
eurjchem-1748	65	15	coupling	coupling	ADJ
eurjchem-1748	65	16	reaction	reaction	NOUN
eurjchem-1748	65	17	conditions	condition	NOUN
eurjchem-1748	65	18	to	to	PART
eurjchem-1748	65	19	obtain	obtain	VERB
eurjchem-1748	65	20	novel	novel	ADJ
eurjchem-1748	65	21	substituted	substitute	VERB
eurjchem-1748	65	22	quinazolinones	quinazolinone	NOUN
eurjchem-1748	65	23	.	.	PUNCT
eurjchem-1748	66	1	based	base	VERB
eurjchem-1748	66	2	on	on	ADP
eurjchem-1748	66	3	our	our	PRON
eurjchem-1748	66	4	previous	previous	ADJ
eurjchem-1748	66	5	experience	experience	NOUN
eurjchem-1748	66	6	on	on	ADP
eurjchem-1748	66	7	c	c	PROPN
eurjchem-1748	66	8	–	–	PUNCT
eurjchem-1748	66	9	c	c	NOUN
eurjchem-1748	66	10	cross	cross	ADJ
eurjchem-1748	66	11	-	-	ADJ
eurjchem-1748	66	12	coupling	coupling	ADJ
eurjchem-1748	66	13	reactions	reaction	NOUN
eurjchem-1748	66	14	,	,	PUNCT
eurjchem-1748	66	15	we	we	PRON
eurjchem-1748	66	16	have	have	AUX
eurjchem-1748	66	17	chosen	choose	VERB
eurjchem-1748	66	18	pd(pph3)4	pd(pph3)4	PROPN
eurjchem-1748	66	19	,	,	PUNCT
eurjchem-1748	66	20	pdcl2	pdcl2	NOUN
eurjchem-1748	66	21	(	(	PUNCT
eurjchem-1748	66	22	pph3)2	pph3)2	PROPN
eurjchem-1748	66	23	,	,	PUNCT
eurjchem-1748	66	24	pdcl2(dcpf	pdcl2(dcpf	PROPN
eurjchem-1748	66	25	)	)	PUNCT
eurjchem-1748	66	26	,	,	PUNCT
eurjchem-1748	66	27	pd(dppf	pd(dppf	PROPN
eurjchem-1748	66	28	)	)	PUNCT
eurjchem-1748	66	29	and	and	CCONJ
eurjchem-1748	66	30	pd(oac)2	pd(oac)2	NOUN
eurjchem-1748	66	31	as	as	ADP
eurjchem-1748	66	32	different	different	ADJ
eurjchem-1748	66	33	palladium	palladium	NOUN
eurjchem-1748	66	34	-	-	PUNCT
eurjchem-1748	66	35	based	base	VERB
eurjchem-1748	66	36	pre	pre	ADJ
eurjchem-1748	66	37	-	-	ADJ
eurjchem-1748	66	38	catalyst	catalyst	ADJ
eurjchem-1748	66	39	systems	system	NOUN
eurjchem-1748	66	40	for	for	ADP
eurjchem-1748	66	41	screening	screen	VERB
eurjchem-1748	66	42	with	with	ADP
eurjchem-1748	66	43	different	different	ADJ
eurjchem-1748	66	44	bases	basis	NOUN
eurjchem-1748	66	45	like	like	ADP
eurjchem-1748	66	46	k2co3	k2co3	ADJ
eurjchem-1748	66	47	,	,	PUNCT
eurjchem-1748	66	48	na2co3	na2co3	ADJ
eurjchem-1748	66	49	,	,	PUNCT
eurjchem-1748	66	50	cs2co3	cs2co3	VERB
eurjchem-1748	66	51	and	and	CCONJ
eurjchem-1748	66	52	k3po4	k3po4	NOUN
eurjchem-1748	66	53	in	in	ADP
eurjchem-1748	66	54	solvents	solvent	NOUN
eurjchem-1748	66	55	1,4	1,4	NUM
eurjchem-1748	66	56	-	-	PUNCT
eurjchem-1748	66	57	dioxane	dioxane	NOUN
eurjchem-1748	66	58	:	:	PUNCT
eurjchem-1748	66	59	h20	h20	NOUN
eurjchem-1748	66	60	(	(	PUNCT
eurjchem-1748	66	61	3:1	3:1	NUM
eurjchem-1748	66	62	,	,	PUNCT
eurjchem-1748	66	63	v	v	NOUN
eurjchem-1748	66	64	:	:	PUNCT
eurjchem-1748	66	65	v	v	NOUN
eurjchem-1748	66	66	)	)	PUNCT
eurjchem-1748	66	67	,	,	PUNCT
eurjchem-1748	66	68	thf	thf	NOUN
eurjchem-1748	66	69	:	:	PUNCT
eurjchem-1748	66	70	h20	h20	PROPN
eurjchem-1748	66	71	(	(	PUNCT
eurjchem-1748	66	72	3:1	3:1	NUM
eurjchem-1748	66	73	,	,	PUNCT
eurjchem-1748	66	74	v	v	NOUN
eurjchem-1748	66	75	:	:	PUNCT
eurjchem-1748	66	76	v	v	NOUN
eurjchem-1748	66	77	)	)	PUNCT
eurjchem-1748	66	78	and	and	CCONJ
eurjchem-1748	66	79	toluene	toluene	NOUN
eurjchem-1748	66	80	:	:	PUNCT
eurjchem-1748	66	81	h2o	h2o	PROPN
eurjchem-1748	66	82	(	(	PUNCT
eurjchem-1748	66	83	3:1	3:1	NUM
eurjchem-1748	66	84	,	,	PUNCT
eurjchem-1748	66	85	v	v	NOUN
eurjchem-1748	66	86	:	:	PUNCT
eurjchem-1748	66	87	v	v	NOUN
eurjchem-1748	66	88	)	)	PUNCT
eurjchem-1748	66	89	at	at	ADP
eurjchem-1748	66	90	reflux	reflux	NOUN
eurjchem-1748	66	91	.	.	PUNCT
eurjchem-1748	67	1	but	but	CCONJ
eurjchem-1748	67	2	,	,	PUNCT
eurjchem-1748	67	3	all	all	PRON
eurjchem-1748	67	4	of	of	ADP
eurjchem-1748	67	5	the	the	DET
eurjchem-1748	67	6	methods	method	NOUN
eurjchem-1748	67	7	failed	fail	VERB
eurjchem-1748	67	8	to	to	PART
eurjchem-1748	67	9	yield	yield	VERB
eurjchem-1748	67	10	substituted	substitute	VERB
eurjchem-1748	67	11	quinazolinones	quinazolinone	NOUN
eurjchem-1748	67	12	.	.	PUNCT
eurjchem-1748	68	1	the	the	DET
eurjchem-1748	68	2	initial	initial	ADJ
eurjchem-1748	68	3	experiments	experiment	NOUN
eurjchem-1748	68	4	were	be	AUX
eurjchem-1748	68	5	performed	perform	VERB
eurjchem-1748	68	6	without	without	ADP
eurjchem-1748	68	7	using	use	VERB
eurjchem-1748	68	8	any	any	DET
eurjchem-1748	68	9	ligand	ligand	NOUN
eurjchem-1748	68	10	and	and	CCONJ
eurjchem-1748	68	11	were	be	AUX
eurjchem-1748	68	12	unsuccessful	unsuccessful	ADJ
eurjchem-1748	68	13	to	to	PART
eurjchem-1748	68	14	prepare	prepare	VERB
eurjchem-1748	68	15	compounds	compound	NOUN
eurjchem-1748	68	16	8	8	NUM
eurjchem-1748	68	17	to	to	PART
eurjchem-1748	68	18	27	27	NUM
eurjchem-1748	68	19	.	.	PUNCT
eurjchem-1748	69	1	the	the	DET
eurjchem-1748	69	2	development	development	NOUN
eurjchem-1748	69	3	of	of	ADP
eurjchem-1748	69	4	easy	easy	ADJ
eurjchem-1748	69	5	synthetic	synthetic	ADJ
eurjchem-1748	69	6	strategies	strategy	NOUN
eurjchem-1748	69	7	for	for	ADP
eurjchem-1748	69	8	the	the	DET
eurjchem-1748	69	9	construction	construction	NOUN
eurjchem-1748	69	10	of	of	ADP
eurjchem-1748	69	11	carbon	carbon	NOUN
eurjchem-1748	69	12	-	-	PUNCT
eurjchem-1748	69	13	carbon	carbon	NOUN
eurjchem-1748	69	14	bonds	bond	NOUN
eurjchem-1748	69	15	with	with	ADP
eurjchem-1748	69	16	palladium	palladium	NOUN
eurjchem-1748	69	17	catalyzed	catalyze	VERB
eurjchem-1748	69	18	suzuki	suzuki	NOUN
eurjchem-1748	69	19	-	-	PUNCT
eurjchem-1748	69	20	miyaura	miyaura	NOUN
eurjchem-1748	69	21	cross	cross	ADJ
eurjchem-1748	69	22	-	-	ADJ
eurjchem-1748	69	23	coupling	coupling	ADJ
eurjchem-1748	69	24	reactions	reaction	NOUN
eurjchem-1748	69	25	remains	remain	VERB
eurjchem-1748	69	26	an	an	DET
eurjchem-1748	69	27	important	important	ADJ
eurjchem-1748	69	28	challenge	challenge	NOUN
eurjchem-1748	69	29	in	in	ADP
eurjchem-1748	69	30	organic	organic	ADJ
eurjchem-1748	69	31	synthesis	synthesis	NOUN
eurjchem-1748	69	32	.	.	PUNCT
eurjchem-1748	70	1	7	7	NUM
eurjchem-1748	70	2	-	-	PUNCT
eurjchem-1748	70	3	chloro-2	chloro-2	NUM
eurjchem-1748	70	4	-	-	PUNCT
eurjchem-1748	70	5	morpholino	morpholino	NOUN
eurjchem-1748	70	6	-	-	PUNCT
eurjchem-1748	70	7	n(pyridin-2	n(pyridin-2	NOUN
eurjchem-1748	70	8	-	-	PUNCT
eurjchem-1748	70	9	ylmethyl)quinazolin-4	ylmethyl)quinazolin-4	NOUN
eurjchem-1748	70	10	-	-	PUNCT
eurjchem-1748	70	11	amine	amine	NOUN
eurjchem-1748	70	12	were	be	AUX
eurjchem-1748	70	13	chosen	choose	VERB
eurjchem-1748	70	14	for	for	ADP
eurjchem-1748	70	15	the	the	DET
eurjchem-1748	70	16	present	present	ADJ
eurjchem-1748	70	17	study	study	NOUN
eurjchem-1748	70	18	.	.	PUNCT
eurjchem-1748	71	1	the	the	DET
eurjchem-1748	71	2	overall	overall	ADJ
eurjchem-1748	71	3	aim	aim	NOUN
eurjchem-1748	71	4	was	be	AUX
eurjchem-1748	71	5	not	not	PART
eurjchem-1748	71	6	only	only	ADV
eurjchem-1748	71	7	to	to	PART
eurjchem-1748	71	8	determine	determine	VERB
eurjchem-1748	71	9	the	the	DET
eurjchem-1748	71	10	best	good	ADJ
eurjchem-1748	71	11	conditions	condition	NOUN
eurjchem-1748	71	12	for	for	ADP
eurjchem-1748	71	13	suzuki	suzuki	NOUN
eurjchem-1748	71	14	-	-	PUNCT
eurjchem-1748	71	15	miyaura	miyaura	NOUN
eurjchem-1748	71	16	cross	cross	NOUN
eurjchem-1748	71	17	coupling	coupling	NOUN
eurjchem-1748	71	18	reactions	reaction	NOUN
eurjchem-1748	71	19	,	,	PUNCT
eurjchem-1748	71	20	but	but	CCONJ
eurjchem-1748	71	21	also	also	ADV
eurjchem-1748	71	22	to	to	PART
eurjchem-1748	71	23	find	find	VERB
eurjchem-1748	71	24	the	the	DET
eurjchem-1748	71	25	optimal	optimal	ADJ
eurjchem-1748	71	26	conditions	condition	NOUN
eurjchem-1748	71	27	that	that	PRON
eurjchem-1748	71	28	can	can	AUX
eurjchem-1748	71	29	be	be	AUX
eurjchem-1748	71	30	applied	apply	VERB
eurjchem-1748	71	31	for	for	ADP
eurjchem-1748	71	32	the	the	DET
eurjchem-1748	71	33	synthesis	synthesis	NOUN
eurjchem-1748	71	34	of	of	ADP
eurjchem-1748	71	35	a	a	DET
eurjchem-1748	71	36	broad	broad	ADJ
eurjchem-1748	71	37	range	range	NOUN
eurjchem-1748	71	38	of	of	ADP
eurjchem-1748	71	39	7	7	NUM
eurjchem-1748	71	40	-	-	PUNCT
eurjchem-1748	71	41	aryl	aryl	NOUN
eurjchem-1748	71	42	,	,	PUNCT
eurjchem-1748	71	43	heteroaryl	heteroaryl	NOUN
eurjchem-1748	71	44	,	,	PUNCT
eurjchem-1748	71	45	and	and	CCONJ
eurjchem-1748	71	46	biphenyl	biphenyl	NOUN
eurjchem-1748	71	47	quinazolin-4	quinazolin-4	PROPN
eurjchem-1748	71	48	-	-	NOUN
eurjchem-1748	71	49	amine	amine	ADJ
eurjchem-1748	71	50	.	.	PUNCT
eurjchem-1748	72	1	optimization	optimization	NOUN
eurjchem-1748	72	2	experiments	experiment	NOUN
eurjchem-1748	72	3	were	be	AUX
eurjchem-1748	72	4	carried	carry	VERB
eurjchem-1748	72	5	out	out	ADP
eurjchem-1748	72	6	using	use	VERB
eurjchem-1748	72	7	pd(pph3)4	pd(pph3)4	PRON
eurjchem-1748	72	8	,	,	PUNCT
eurjchem-1748	72	9	pdcl2(pph3)2	pdcl2(pph3)2	ADJ
eurjchem-1748	72	10	,	,	PUNCT
eurjchem-1748	72	11	pdcl2(dcpf	pdcl2(dcpf	PROPN
eurjchem-1748	72	12	)	)	PUNCT
eurjchem-1748	72	13	,	,	PUNCT
eurjchem-1748	72	14	pdcl2(dtbpf	pdcl2(dtbpf	PROPN
eurjchem-1748	72	15	)	)	PUNCT
eurjchem-1748	72	16	,	,	PUNCT
eurjchem-1748	72	17	pdcl2(dppf	pdcl2(dppf	PROPN
eurjchem-1748	72	18	)	)	PUNCT
eurjchem-1748	72	19	,	,	PUNCT
eurjchem-1748	72	20	pd(oac)2	pd(oac)2	NOUN
eurjchem-1748	72	21	and	and	CCONJ
eurjchem-1748	72	22	pd2(dba)3	pd2(dba)3	INTJ
eurjchem-1748	72	23	as	as	ADP
eurjchem-1748	72	24	metal	metal	NOUN
eurjchem-1748	72	25	sources	source	NOUN
eurjchem-1748	72	26	,	,	PUNCT
eurjchem-1748	72	27	ligands	ligand	NOUN
eurjchem-1748	72	28	l1	l1	PROPN
eurjchem-1748	72	29	–	–	PUNCT
eurjchem-1748	72	30	l6	l6	PROPN
eurjchem-1748	72	31	(	(	PUNCT
eurjchem-1748	72	32	figure	figure	NOUN
eurjchem-1748	72	33	2	2	NUM
eurjchem-1748	72	34	)	)	PUNCT
eurjchem-1748	72	35	were	be	AUX
eurjchem-1748	72	36	selected	select	VERB
eurjchem-1748	72	37	for	for	ADP
eurjchem-1748	72	38	combination	combination	NOUN
eurjchem-1748	72	39	with	with	ADP
eurjchem-1748	72	40	the	the	DET
eurjchem-1748	72	41	metal	metal	NOUN
eurjchem-1748	72	42	.	.	PUNCT
eurjchem-1748	73	1	after	after	ADP
eurjchem-1748	73	2	trying	try	VERB
eurjchem-1748	73	3	several	several	ADJ
eurjchem-1748	73	4	combinations	combination	NOUN
eurjchem-1748	73	5	of	of	ADP
eurjchem-1748	73	6	catalyst	catalyst	NOUN
eurjchem-1748	73	7	and	and	CCONJ
eurjchem-1748	73	8	ligand	ligand	NOUN
eurjchem-1748	73	9	in	in	ADP
eurjchem-1748	73	10	different	different	ADJ
eurjchem-1748	73	11	bases	basis	NOUN
eurjchem-1748	73	12	k2co3	k2co3	ADJ
eurjchem-1748	73	13	,	,	PUNCT
eurjchem-1748	73	14	na2co3	na2co3	ADJ
eurjchem-1748	73	15	,	,	PUNCT
eurjchem-1748	73	16	cs2co3	cs2co3	ADJ
eurjchem-1748	73	17	and	and	CCONJ
eurjchem-1748	73	18	k3po4	k3po4	NOUN
eurjchem-1748	73	19	,	,	PUNCT
eurjchem-1748	73	20	we	we	PRON
eurjchem-1748	73	21	optimized	optimize	VERB
eurjchem-1748	73	22	the	the	DET
eurjchem-1748	73	23	conditions	condition	NOUN
eurjchem-1748	73	24	in	in	ADP
eurjchem-1748	73	25	microwave	microwave	NOUN
eurjchem-1748	73	26	pd(oac)2	pd(oac)2	NOUN
eurjchem-1748	73	27	,	,	PUNCT
eurjchem-1748	73	28	x	x	NOUN
eurjchem-1748	73	29	-	-	NOUN
eurjchem-1748	73	30	phos	phos	NOUN
eurjchem-1748	73	31	,	,	PUNCT
eurjchem-1748	73	32	k3po4	k3po4	NOUN
eurjchem-1748	73	33	,	,	PUNCT
eurjchem-1748	73	34	thf	thf	NOUN
eurjchem-1748	73	35	,	,	PUNCT
eurjchem-1748	73	36	h2o	h2o	PROPN
eurjchem-1748	73	37	(	(	PUNCT
eurjchem-1748	73	38	3:1	3:1	NUM
eurjchem-1748	73	39	)	)	PUNCT
eurjchem-1748	73	40	,	,	PUNCT
eurjchem-1748	73	41	120	120	NUM
eurjchem-1748	73	42	°	°	NOUN
eurjchem-1748	73	43	c	c	NOUN
eurjchem-1748	73	44	,	,	PUNCT
eurjchem-1748	73	45	30	30	NUM
eurjchem-1748	73	46	min	min	NOUN
eurjchem-1748	73	47	,	,	PUNCT
eurjchem-1748	73	48	and	and	CCONJ
eurjchem-1748	73	49	prepared	prepared	ADJ
eurjchem-1748	73	50	compounds	compound	NOUN
eurjchem-1748	73	51	8	8	NUM
eurjchem-1748	73	52	to	to	PART
eurjchem-1748	73	53	27	27	NUM
eurjchem-1748	73	54	in	in	ADP
eurjchem-1748	73	55	62	62	NUM
eurjchem-1748	73	56	to	to	PART
eurjchem-1748	73	57	88	88	NUM
eurjchem-1748	73	58	%	%	NOUN
eurjchem-1748	73	59	yield	yield	NOUN
eurjchem-1748	73	60	(	(	PUNCT
eurjchem-1748	73	61	scheme	scheme	NOUN
eurjchem-1748	73	62	2	2	NUM
eurjchem-1748	73	63	)	)	PUNCT
eurjchem-1748	73	64	.	.	PUNCT
eurjchem-1748	74	1	after	after	ADP
eurjchem-1748	74	2	finalizing	finalize	VERB
eurjchem-1748	74	3	the	the	DET
eurjchem-1748	74	4	optimal	optimal	ADJ
eurjchem-1748	74	5	conditions	condition	NOUN
eurjchem-1748	74	6	,	,	PUNCT
eurjchem-1748	74	7	several	several	ADJ
eurjchem-1748	74	8	boronic	boronic	ADJ
eurjchem-1748	74	9	acids	acid	NOUN
eurjchem-1748	74	10	were	be	AUX
eurjchem-1748	74	11	employed	employ	VERB
eurjchem-1748	74	12	which	which	PRON
eurjchem-1748	74	13	underwent	undergo	VERB
eurjchem-1748	74	14	cross	cross	NOUN
eurjchem-1748	74	15	coupling	coupling	NOUN
eurjchem-1748	74	16	reactions	reaction	NOUN
eurjchem-1748	74	17	at	at	ADP
eurjchem-1748	74	18	120	120	NUM
eurjchem-1748	74	19	°	°	NOUN
eurjchem-1748	74	20	c	c	NOUN
eurjchem-1748	74	21	,	,	PUNCT
eurjchem-1748	74	22	30	30	NUM
eurjchem-1748	74	23	min	min	NOUN
eurjchem-1748	74	24	,	,	PUNCT
eurjchem-1748	74	25	and	and	CCONJ
eurjchem-1748	74	26	microwave	microwave	NOUN
eurjchem-1748	74	27	to	to	PART
eurjchem-1748	74	28	produce	produce	VERB
eurjchem-1748	74	29	the	the	DET
eurjchem-1748	74	30	analogs	analog	NOUN
eurjchem-1748	74	31	shown	show	VERB
eurjchem-1748	74	32	in	in	ADP
eurjchem-1748	74	33	table	table	NOUN
eurjchem-1748	74	34	1	1	NUM
eurjchem-1748	74	35	.	.	SYM
eurjchem-1748	74	36	2018	2018	NUM
eurjchem-1748	74	37	–	–	PUNCT
eurjchem-1748	74	38	european	european	ADJ
eurjchem-1748	74	39	journal	journal	NOUN
eurjchem-1748	74	40	of	of	ADP
eurjchem-1748	74	41	chemistry	chemistry	NOUN
eurjchem-1748	74	42	–	–	PUNCT
eurjchem-1748	74	43	cc	cc	NOUN
eurjchem-1748	74	44	by	by	ADP
eurjchem-1748	74	45	nc	nc	PROPN
eurjchem-1748	74	46	–	–	PUNCT
eurjchem-1748	74	47	doi	doi	PROPN
eurjchem-1748	74	48	:	:	PUNCT
eurjchem-1748	74	49	10.5155	10.5155	NUM
eurjchem-1748	74	50	/	/	SYM
eurjchem-1748	74	51	eurjchem.9.4.322	eurjchem.9.4.322	PROPN
eurjchem-1748	74	52	-	-	PUNCT
eurjchem-1748	74	53	330.1748	330.1748	NUM
eurjchem-1748	74	54	324	324	NUM
eurjchem-1748	74	55	ankireddy	ankireddy	NOUN
eurjchem-1748	74	56	et	et	PROPN
eurjchem-1748	74	57	al	al	PROPN
eurjchem-1748	74	58	.	.	PUNCT
eurjchem-1748	74	59	/	/	SYM
eurjchem-1748	74	60	european	european	PROPN
eurjchem-1748	74	61	journal	journal	PROPN
eurjchem-1748	74	62	of	of	ADP
eurjchem-1748	74	63	chemistry	chemistry	NOUN
eurjchem-1748	74	64	9	9	NUM
eurjchem-1748	74	65	(	(	PUNCT
eurjchem-1748	74	66	4	4	NUM
eurjchem-1748	74	67	)	)	PUNCT
eurjchem-1748	74	68	(	(	PUNCT
eurjchem-1748	74	69	2018	2018	NUM
eurjchem-1748	74	70	)	)	PUNCT
eurjchem-1748	74	71	322	322	NUM
eurjchem-1748	74	72	-	-	SYM
eurjchem-1748	74	73	330	330	NUM
eurjchem-1748	74	74	o	o	NOUN
eurjchem-1748	74	75	h3c	h3c	VERB
eurjchem-1748	74	76	o	o	X
eurjchem-1748	74	77	s	s	PROPN
eurjchem-1748	74	78	-	-	PUNCT
eurjchem-1748	74	79	phos	phos	PROPN
eurjchem-1748	74	80	l1	l1	PROPN
eurjchem-1748	74	81	l2	l2	PROPN
eurjchem-1748	74	82	cyclohexyl	cyclohexyl	PROPN
eurjchem-1748	74	83	john	john	PROPN
eurjchem-1748	74	84	-	-	PUNCT
eurjchem-1748	74	85	phos	phos	PROPN
eurjchem-1748	74	86	l3	l3	PROPN
eurjchem-1748	74	87	ch3	ch3	PROPN
eurjchem-1748	74	88	pcy2	pcy2	PROPN
eurjchem-1748	74	89	dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2	dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2	PROPN
eurjchem-1748	74	90	-	-	PUNCT
eurjchem-1748	74	91	yl)phosphine	yl)phosphine	NOUN
eurjchem-1748	74	92	pcy2	pcy2	NOUN
eurjchem-1748	75	1	[	[	X
eurjchem-1748	75	2	1,1'-biphenyl]2	1,1'-biphenyl]2	NUM
eurjchem-1748	75	3	-	-	NUM
eurjchem-1748	75	4	yldicyclohexylphosphine	yldicyclohexylphosphine	NOUN
eurjchem-1748	76	1	i	i	NOUN
eurjchem-1748	76	2	-	-	PUNCT
eurjchem-1748	76	3	pr	pr	VERB
eurjchem-1748	76	4	i	i	PROPN
eurjchem-1748	76	5	-	-	PUNCT
eurjchem-1748	76	6	pri	pri	ADJ
eurjchem-1748	76	7	-	-	PUNCT
eurjchem-1748	76	8	pr	pr	ADJ
eurjchem-1748	76	9	dicyclohexyl(2',4',6'-triisopropyl[1,1'-biphenyl]-2	dicyclohexyl(2',4',6'-triisopropyl[1,1'-biphenyl]-2	ADJ
eurjchem-1748	76	10	-	-	NOUN
eurjchem-1748	76	11	yl)phosphine	yl)phosphine	NOUN
eurjchem-1748	76	12	pcy2	pcy2	PROPN
eurjchem-1748	76	13	x	x	PROPN
eurjchem-1748	76	14	-	-	PROPN
eurjchem-1748	76	15	phos	phos	PROPN
eurjchem-1748	76	16	l4	l4	PROPN
eurjchem-1748	76	17	john	john	PROPN
eurjchem-1748	76	18	-	-	PUNCT
eurjchem-1748	76	19	phos	phos	PROPN
eurjchem-1748	76	20	t	t	PROPN
eurjchem-1748	76	21	-	-	PUNCT
eurjchem-1748	76	22	bu	bu	PROPN
eurjchem-1748	76	23	t	t	PROPN
eurjchem-1748	76	24	-	-	PUNCT
eurjchem-1748	76	25	bu	bu	NOUN
eurjchem-1748	76	26	2-(2,2,4,4	2-(2,2,4,4	PROPN
eurjchem-1748	76	27	-	-	PUNCT
eurjchem-1748	76	28	tetramethylpentan-3	tetramethylpentan-3	NUM
eurjchem-1748	76	29	-	-	PUNCT
eurjchem-1748	76	30	yl	yl	NOUN
eurjchem-1748	76	31	)	)	PUNCT
eurjchem-1748	76	32	-1,1'-biphenyl	-1,1'-biphenyl	PROPN
eurjchem-1748	76	33	l5	l5	PROPN
eurjchem-1748	76	34	deve	deve	PROPN
eurjchem-1748	76	35	-	-	PUNCT
eurjchem-1748	76	36	phos	phos	NOUN
eurjchem-1748	76	37	pcy2	pcy2	PROPN
eurjchem-1748	76	38	n	n	PROPN
eurjchem-1748	76	39	ch3	ch3	PROPN
eurjchem-1748	76	40	h3c	h3c	PART
eurjchem-1748	76	41	2'-(dicyclohexylphosphino	2'-(dicyclohexylphosphino	NUM
eurjchem-1748	76	42	)	)	PUNCT
eurjchem-1748	76	43	-n	-n	X
eurjchem-1748	76	44	,	,	PUNCT
eurjchem-1748	76	45	n	n	CCONJ
eurjchem-1748	76	46	-	-	PUNCT
eurjchem-1748	76	47	dimethyl-[1,1'-biphenyl]-2	dimethyl-[1,1'-biphenyl]-2	ADV
eurjchem-1748	76	48	-	-	PUNCT
eurjchem-1748	76	49	amine	amine	NOUN
eurjchem-1748	76	50	l6	l6	NOUN
eurjchem-1748	76	51	i	i	NOUN
eurjchem-1748	76	52	-	-	PUNCT
eurjchem-1748	76	53	pr	pr	VERB
eurjchem-1748	77	1	i	i	PROPN
eurjchem-1748	77	2	-	-	PUNCT
eurjchem-1748	77	3	pri	pri	NOUN
eurjchem-1748	77	4	-	-	ADJ
eurjchem-1748	77	5	pr	pr	ADJ
eurjchem-1748	77	6	ptbu2	ptbu2	ADV
eurjchem-1748	77	7	tert	tert	NOUN
eurjchem-1748	77	8	-	-	PUNCT
eurjchem-1748	77	9	butyl	butyl	NOUN
eurjchem-1748	77	10	-	-	PUNCT
eurjchem-1748	77	11	x	x	NOUN
eurjchem-1748	77	12	-	-	NOUN
eurjchem-1748	77	13	phos	phos	ADJ
eurjchem-1748	77	14	dibutyl(2',4',6'-triisopropyl[1,1'-biphenyl]-2	dibutyl(2',4',6'-triisopropyl[1,1'-biphenyl]-2	VERB
eurjchem-1748	77	15	-	-	PUNCT
eurjchem-1748	77	16	yl)platinum	yl)platinum	NOUN
eurjchem-1748	77	17	figure	figure	NOUN
eurjchem-1748	77	18	2	2	NUM
eurjchem-1748	77	19	.	.	PUNCT
eurjchem-1748	77	20	structure	structure	NOUN
eurjchem-1748	77	21	of	of	ADP
eurjchem-1748	77	22	ligands	ligand	NOUN
eurjchem-1748	77	23	used	use	VERB
eurjchem-1748	77	24	in	in	ADP
eurjchem-1748	77	25	suzuki	suzuki	NOUN
eurjchem-1748	77	26	reactions	reaction	NOUN
eurjchem-1748	77	27	.	.	PUNCT
eurjchem-1748	78	1	nh2	nh2	NOUN
eurjchem-1748	79	1	oh	oh	INTJ
eurjchem-1748	79	2	o	o	INTJ
eurjchem-1748	79	3	cl	cl	NOUN
eurjchem-1748	79	4	h2n	h2n	PROPN
eurjchem-1748	80	1	nh2	nh2	PROPN
eurjchem-1748	80	2	o	o	PROPN
eurjchem-1748	80	3	neat	neat	ADJ
eurjchem-1748	80	4	,	,	PUNCT
eurjchem-1748	80	5	200	200	NUM
eurjchem-1748	80	6	°	°	NOUN
eurjchem-1748	80	7	c	c	NOUN
eurjchem-1748	80	8	,	,	PUNCT
eurjchem-1748	80	9	8	8	NUM
eurjchem-1748	80	10	h	h	NOUN
eurjchem-1748	80	11	n	n	PRON
eurjchem-1748	80	12	h	h	NOUN
eurjchem-1748	80	13	nh	nh	NOUN
eurjchem-1748	80	14	o	o	NOUN
eurjchem-1748	80	15	cl	cl	NOUN
eurjchem-1748	80	16	o	o	X
eurjchem-1748	80	17	pocl3	pocl3	NOUN
eurjchem-1748	80	18	n	n	CCONJ
eurjchem-1748	80	19	,	,	PUNCT
eurjchem-1748	80	20	n	n	CCONJ
eurjchem-1748	80	21	-	-	PUNCT
eurjchem-1748	80	22	dimethylaniline	dimethylaniline	NOUN
eurjchem-1748	80	23	n	n	CCONJ
eurjchem-1748	80	24	n	n	CCONJ
eurjchem-1748	80	25	cl	cl	NOUN
eurjchem-1748	80	26	cl	cl	NOUN
eurjchem-1748	80	27	cl	cl	NOUN
eurjchem-1748	80	28	n	n	CCONJ
eurjchem-1748	80	29	h2n	h2n	VERB
eurjchem-1748	80	30	thf	thf	NOUN
eurjchem-1748	80	31	n	n	CCONJ
eurjchem-1748	80	32	n	n	NOUN
eurjchem-1748	80	33	hn	hn	PROPN
eurjchem-1748	80	34	cl	cl	NOUN
eurjchem-1748	80	35	cl	cl	NOUN
eurjchem-1748	81	1	n	n	CCONJ
eurjchem-1748	81	2	n	n	CCONJ
eurjchem-1748	81	3	n	n	ADV
eurjchem-1748	81	4	hn	hn	PROPN
eurjchem-1748	81	5	cl	cl	NOUN
eurjchem-1748	81	6	n	n	CCONJ
eurjchem-1748	81	7	n	n	ADV
eurjchem-1748	82	1	o	o	NOUN
eurjchem-1748	83	1	hn	hn	PRON
eurjchem-1748	83	2	o	o	NOUN
eurjchem-1748	83	3	2	2	NUM
eurjchem-1748	83	4	3	3	NUM
eurjchem-1748	83	5	5	5	NUM
eurjchem-1748	83	6	7	7	NUM
eurjchem-1748	83	7	dipea	dipea	NOUN
eurjchem-1748	83	8	,	,	PUNCT
eurjchem-1748	83	9	ipa	ipa	PROPN
eurjchem-1748	83	10	100	100	NUM
eurjchem-1748	84	1	°	°	ADP
eurjchem-1748	84	2	c	c	NOUN
eurjchem-1748	84	3	,	,	PUNCT
eurjchem-1748	84	4	12	12	NUM
eurjchem-1748	84	5	h	h	NOUN
eurjchem-1748	84	6	120	120	NUM
eurjchem-1748	84	7	°	°	NOUN
eurjchem-1748	84	8	c	c	NOUN
eurjchem-1748	84	9	,	,	PUNCT
eurjchem-1748	84	10	8	8	NUM
eurjchem-1748	84	11	h	h	NOUN
eurjchem-1748	84	12	rt	rt	PROPN
eurjchem-1748	84	13	,	,	PUNCT
eurjchem-1748	84	14	12	12	NUM
eurjchem-1748	84	15	h	h	NOUN
eurjchem-1748	84	16	1	1	NUM
eurjchem-1748	84	17	64	64	NUM
eurjchem-1748	84	18	n	n	CCONJ
eurjchem-1748	84	19	n	n	PRON
eurjchem-1748	84	20	cl	cl	NOUN
eurjchem-1748	84	21	cl	cl	NOUN
eurjchem-1748	84	22	cl	cl	NOUN
eurjchem-1748	84	23	3	3	NUM
eurjchem-1748	84	24	scheme	scheme	NOUN
eurjchem-1748	84	25	1	1	NUM
eurjchem-1748	84	26	.	.	PUNCT
eurjchem-1748	84	27	synthesis	synthesis	NOUN
eurjchem-1748	84	28	of	of	ADP
eurjchem-1748	84	29	7	7	NUM
eurjchem-1748	84	30	-	-	PUNCT
eurjchem-1748	84	31	chloro-2	chloro-2	NUM
eurjchem-1748	84	32	-	-	PUNCT
eurjchem-1748	84	33	morpholino	morpholino	NOUN
eurjchem-1748	84	34	-	-	PUNCT
eurjchem-1748	84	35	n-(pyridin-2	n-(pyridin-2	NUM
eurjchem-1748	84	36	-	-	PUNCT
eurjchem-1748	84	37	ylmethyl)quinazolin-4	ylmethyl)quinazolin-4	NOUN
eurjchem-1748	84	38	-	-	PUNCT
eurjchem-1748	84	39	amine	amine	NOUN
eurjchem-1748	84	40	(	(	PUNCT
eurjchem-1748	84	41	compound	compound	NOUN
eurjchem-1748	84	42	7	7	NUM
eurjchem-1748	84	43	)	)	PUNCT
eurjchem-1748	84	44	.	.	PUNCT
eurjchem-1748	85	1	from	from	ADP
eurjchem-1748	85	2	table	table	NOUN
eurjchem-1748	85	3	1	1	NUM
eurjchem-1748	85	4	,	,	PUNCT
eurjchem-1748	85	5	it	it	PRON
eurjchem-1748	85	6	is	be	AUX
eurjchem-1748	85	7	clear	clear	ADJ
eurjchem-1748	85	8	that	that	SCONJ
eurjchem-1748	85	9	a	a	DET
eurjchem-1748	85	10	wide	wide	ADJ
eurjchem-1748	85	11	assortment	assortment	NOUN
eurjchem-1748	85	12	of	of	ADP
eurjchem-1748	85	13	aryl	aryl	NOUN
eurjchem-1748	85	14	,	,	PUNCT
eurjchem-1748	85	15	heteroaryl	heteroaryl	NOUN
eurjchem-1748	85	16	and	and	CCONJ
eurjchem-1748	85	17	biphenyl	biphenyl	NOUN
eurjchem-1748	85	18	boronic	boronic	ADJ
eurjchem-1748	85	19	acids	acid	NOUN
eurjchem-1748	85	20	undergo	undergo	VERB
eurjchem-1748	85	21	pd	pd	ADJ
eurjchem-1748	85	22	-	-	PUNCT
eurjchem-1748	85	23	catalyzed	catalyze	VERB
eurjchem-1748	85	24	suzuki	suzuki	NOUN
eurjchem-1748	85	25	-	-	PUNCT
eurjchem-1748	85	26	miyaura	miyaura	NOUN
eurjchem-1748	85	27	cross	cross	NOUN
eurjchem-1748	85	28	coupling	coupling	NOUN
eurjchem-1748	85	29	reactions	reaction	NOUN
eurjchem-1748	85	30	.	.	PUNCT
eurjchem-1748	86	1	the	the	DET
eurjchem-1748	86	2	final	final	ADJ
eurjchem-1748	86	3	c	c	NOUN
eurjchem-1748	86	4	–	–	PUNCT
eurjchem-1748	86	5	c	c	NOUN
eurjchem-1748	86	6	coupling	couple	VERB
eurjchem-1748	86	7	products	product	NOUN
eurjchem-1748	86	8	of	of	ADP
eurjchem-1748	86	9	boronic	boronic	ADJ
eurjchem-1748	86	10	acids	acid	NOUN
eurjchem-1748	86	11	with	with	ADP
eurjchem-1748	86	12	electron	electron	NOUN
eurjchem-1748	86	13	withdrawing	withdraw	VERB
eurjchem-1748	86	14	groups	group	NOUN
eurjchem-1748	86	15	like	like	ADP
eurjchem-1748	86	16	2	2	NUM
eurjchem-1748	86	17	-	-	PUNCT
eurjchem-1748	86	18	carboxylicphenyl	carboxylicphenyl	NOUN
eurjchem-1748	86	19	boronic	boronic	ADJ
eurjchem-1748	86	20	acid	acid	NOUN
eurjchem-1748	86	21	(	(	PUNCT
eurjchem-1748	86	22	entry	entry	NOUN
eurjchem-1748	86	23	15	15	NUM
eurjchem-1748	86	24	,	,	PUNCT
eurjchem-1748	86	25	88	88	NUM
eurjchem-1748	86	26	%	%	NOUN
eurjchem-1748	86	27	)	)	PUNCT
eurjchem-1748	86	28	,	,	PUNCT
eurjchem-1748	86	29	and	and	CCONJ
eurjchem-1748	86	30	least	least	ADJ
eurjchem-1748	86	31	yield	yield	VERB
eurjchem-1748	86	32	in	in	ADP
eurjchem-1748	86	33	electron	electron	NOUN
eurjchem-1748	86	34	donating	donate	VERB
eurjchem-1748	86	35	group	group	NOUN
eurjchem-1748	86	36	like	like	ADP
eurjchem-1748	86	37	2	2	NUM
eurjchem-1748	86	38	-	-	PUNCT
eurjchem-1748	86	39	methoxyphenyl	methoxyphenyl	NOUN
eurjchem-1748	86	40	boronic	boronic	ADJ
eurjchem-1748	86	41	acid	acid	NOUN
eurjchem-1748	86	42	(	(	PUNCT
eurjchem-1748	86	43	entry	entry	NOUN
eurjchem-1748	86	44	4	4	NUM
eurjchem-1748	86	45	,	,	PUNCT
eurjchem-1748	86	46	62	62	NUM
eurjchem-1748	86	47	%	%	NOUN
eurjchem-1748	86	48	)	)	PUNCT
eurjchem-1748	86	49	.	.	PUNCT
eurjchem-1748	87	1	after	after	ADP
eurjchem-1748	87	2	attempting	attempt	VERB
eurjchem-1748	87	3	several	several	ADJ
eurjchem-1748	87	4	reactions	reaction	NOUN
eurjchem-1748	87	5	,	,	PUNCT
eurjchem-1748	87	6	we	we	PRON
eurjchem-1748	87	7	concluded	conclude	VERB
eurjchem-1748	87	8	that	that	SCONJ
eurjchem-1748	87	9	,	,	PUNCT
eurjchem-1748	87	10	after	after	ADP
eurjchem-1748	87	11	adding	add	VERB
eurjchem-1748	87	12	ligand	ligand	NOUN
eurjchem-1748	87	13	in	in	ADP
eurjchem-1748	87	14	suzuki	suzuki	PROPN
eurjchem-1748	87	15	coupling	coupling	NOUN
eurjchem-1748	87	16	reaction	reaction	NOUN
eurjchem-1748	87	17	on	on	ADP
eurjchem-1748	87	18	compound	compound	NOUN
eurjchem-1748	87	19	7	7	NUM
eurjchem-1748	87	20	,	,	PUNCT
eurjchem-1748	87	21	and	and	CCONJ
eurjchem-1748	87	22	then	then	ADV
eurjchem-1748	87	23	there	there	PRON
eurjchem-1748	87	24	is	be	VERB
eurjchem-1748	87	25	a	a	DET
eurjchem-1748	87	26	formation	formation	NOUN
eurjchem-1748	87	27	of	of	ADP
eurjchem-1748	87	28	desired	desire	VERB
eurjchem-1748	87	29	products	product	NOUN
eurjchem-1748	87	30	8	8	NUM
eurjchem-1748	87	31	to	to	ADP
eurjchem-1748	87	32	27	27	NUM
eurjchem-1748	87	33	.	.	PUNCT
eurjchem-1748	88	1	later	later	ADV
eurjchem-1748	88	2	,	,	PUNCT
eurjchem-1748	88	3	we	we	PRON
eurjchem-1748	88	4	screened	screen	VERB
eurjchem-1748	88	5	different	different	ADJ
eurjchem-1748	88	6	ligands	ligand	NOUN
eurjchem-1748	88	7	with	with	ADP
eurjchem-1748	88	8	different	different	ADJ
eurjchem-1748	88	9	catalyst	catalyst	NOUN
eurjchem-1748	88	10	,	,	PUNCT
eurjchem-1748	88	11	by	by	ADP
eurjchem-1748	88	12	changing	change	VERB
eurjchem-1748	88	13	bases	basis	NOUN
eurjchem-1748	88	14	and	and	CCONJ
eurjchem-1748	88	15	solvents	solvent	NOUN
eurjchem-1748	88	16	.	.	PUNCT
eurjchem-1748	89	1	we	we	PRON
eurjchem-1748	89	2	concluded	conclude	VERB
eurjchem-1748	89	3	that	that	SCONJ
eurjchem-1748	89	4	ligand	ligand	NOUN
eurjchem-1748	89	5	l3	l3	PROPN
eurjchem-1748	89	6	(	(	PUNCT
eurjchem-1748	89	7	xphos	xphos	PROPN
eurjchem-1748	89	8	)	)	PUNCT
eurjchem-1748	89	9	on	on	ADP
eurjchem-1748	89	10	compound	compound	NOUN
eurjchem-1748	89	11	7	7	NUM
eurjchem-1748	89	12	,	,	PUNCT
eurjchem-1748	89	13	and	and	CCONJ
eurjchem-1748	89	14	k3po4	k3po4	NOUN
eurjchem-1748	89	15	as	as	ADP
eurjchem-1748	89	16	a	a	DET
eurjchem-1748	89	17	base	base	NOUN
eurjchem-1748	89	18	,	,	PUNCT
eurjchem-1748	89	19	this	this	DET
eurjchem-1748	89	20	condition	condition	NOUN
eurjchem-1748	89	21	gives	give	VERB
eurjchem-1748	89	22	some	some	DET
eurjchem-1748	89	23	desired	desire	VERB
eurjchem-1748	89	24	product	product	NOUN
eurjchem-1748	89	25	and	and	CCONJ
eurjchem-1748	89	26	also	also	ADV
eurjchem-1748	89	27	thf	thf	NOUN
eurjchem-1748	89	28	was	be	AUX
eurjchem-1748	89	29	superior	superior	ADJ
eurjchem-1748	89	30	to	to	ADP
eurjchem-1748	89	31	1,4dioxane	1,4dioxane	NUM
eurjchem-1748	89	32	and	and	CCONJ
eurjchem-1748	89	33	phme	phme	ADJ
eurjchem-1748	89	34	,	,	PUNCT
eurjchem-1748	89	35	the	the	DET
eurjchem-1748	89	36	ratio	ratio	NOUN
eurjchem-1748	89	37	of	of	ADP
eurjchem-1748	89	38	thf	thf	NOUN
eurjchem-1748	89	39	and	and	CCONJ
eurjchem-1748	89	40	h2o	h2o	NOUN
eurjchem-1748	89	41	is	be	AUX
eurjchem-1748	89	42	(	(	PUNCT
eurjchem-1748	89	43	4:1	4:1	NUM
eurjchem-1748	89	44	,	,	PUNCT
eurjchem-1748	89	45	v	v	NOUN
eurjchem-1748	89	46	:	:	PUNCT
eurjchem-1748	89	47	v	v	NOUN
eurjchem-1748	89	48	)	)	PUNCT
eurjchem-1748	89	49	.	.	PUNCT
eurjchem-1748	90	1	from	from	ADP
eurjchem-1748	90	2	these	these	DET
eurjchem-1748	90	3	data	datum	NOUN
eurjchem-1748	90	4	,	,	PUNCT
eurjchem-1748	90	5	pd(oac)2	pd(oac)2	NOUN
eurjchem-1748	90	6	/	/	SYM
eurjchem-1748	90	7	l3	l3	PROPN
eurjchem-1748	90	8	(	(	PUNCT
eurjchem-1748	90	9	x	x	NOUN
eurjchem-1748	90	10	-	-	NOUN
eurjchem-1748	90	11	phos	phos	NOUN
eurjchem-1748	90	12	)	)	PUNCT
eurjchem-1748	90	13	was	be	AUX
eurjchem-1748	90	14	superior	superior	ADJ
eurjchem-1748	90	15	to	to	ADP
eurjchem-1748	90	16	the	the	DET
eurjchem-1748	90	17	other	other	ADJ
eurjchem-1748	90	18	biaryl	biaryl	NOUN
eurjchem-1748	90	19	-	-	PUNCT
eurjchem-1748	90	20	ligand	ligand	NOUN
eurjchem-1748	90	21	-	-	PUNCT
eurjchem-1748	90	22	based	base	VERB
eurjchem-1748	90	23	catalysts	catalyst	NOUN
eurjchem-1748	90	24	,	,	PUNCT
eurjchem-1748	90	25	which	which	PRON
eurjchem-1748	90	26	gave	give	VERB
eurjchem-1748	90	27	product	product	NOUN
eurjchem-1748	90	28	yields	yield	NOUN
eurjchem-1748	90	29	in	in	ADP
eurjchem-1748	90	30	the	the	DET
eurjchem-1748	90	31	range	range	NOUN
eurjchem-1748	90	32	of	of	ADP
eurjchem-1748	90	33	4–30	4–30	ADJ
eurjchem-1748	90	34	%	%	NOUN
eurjchem-1748	90	35	with	with	ADP
eurjchem-1748	90	36	a	a	DET
eurjchem-1748	90	37	catalytic	catalytic	ADJ
eurjchem-1748	90	38	loading	loading	NOUN
eurjchem-1748	90	39	of	of	ADP
eurjchem-1748	90	40	metal	metal	NOUN
eurjchem-1748	90	41	of	of	ADP
eurjchem-1748	90	42	5	5	NUM
eurjchem-1748	90	43	or	or	CCONJ
eurjchem-1748	90	44	10	10	NUM
eurjchem-1748	90	45	mol%	mol%	NOUN
eurjchem-1748	90	46	.	.	PUNCT
eurjchem-1748	91	1	the	the	DET
eurjchem-1748	91	2	reaction	reaction	NOUN
eurjchem-1748	91	3	of	of	ADP
eurjchem-1748	91	4	10	10	NUM
eurjchem-1748	91	5	mol%	mol%	PROPN
eurjchem-1748	91	6	pd(oac)2	pd(oac)2	NOUN
eurjchem-1748	91	7	in	in	ADP
eurjchem-1748	91	8	the	the	DET
eurjchem-1748	91	9	presence	presence	NOUN
eurjchem-1748	91	10	of	of	ADP
eurjchem-1748	91	11	thf	thf	NOUN
eurjchem-1748	91	12	was	be	AUX
eurjchem-1748	91	13	superior	superior	ADJ
eurjchem-1748	91	14	compared	compare	VERB
eurjchem-1748	91	15	to	to	ADP
eurjchem-1748	91	16	1,4	1,4	NUM
eurjchem-1748	91	17	-	-	PUNCT
eurjchem-1748	91	18	dioxane	dioxane	NOUN
eurjchem-1748	91	19	80	80	NUM
eurjchem-1748	91	20	°	°	NUM
eurjchem-1748	91	21	c	c	NOUN
eurjchem-1748	91	22	for	for	ADP
eurjchem-1748	91	23	16	16	NUM
eurjchem-1748	91	24	h.	h.	NOUN
eurjchem-1748	91	25	whereas	whereas	SCONJ
eurjchem-1748	91	26	,	,	PUNCT
eurjchem-1748	91	27	when	when	SCONJ
eurjchem-1748	91	28	the	the	DET
eurjchem-1748	91	29	reactions	reaction	NOUN
eurjchem-1748	91	30	were	be	AUX
eurjchem-1748	91	31	conducted	conduct	VERB
eurjchem-1748	91	32	in	in	ADP
eurjchem-1748	91	33	the	the	DET
eurjchem-1748	91	34	case	case	NOUN
eurjchem-1748	91	35	of	of	ADP
eurjchem-1748	91	36	5	5	NUM
eurjchem-1748	91	37	mol%	mol%	PROPN
eurjchem-1748	91	38	pd(oac)2	pd(oac)2	NOUN
eurjchem-1748	91	39	,	,	PUNCT
eurjchem-1748	92	1	thf	thf	NOUN
eurjchem-1748	92	2	yields	yield	NOUN
eurjchem-1748	92	3	did	do	AUX
eurjchem-1748	92	4	n’t	not	PART
eurjchem-1748	92	5	change	change	VERB
eurjchem-1748	92	6	appreciably	appreciably	ADV
eurjchem-1748	92	7	,	,	PUNCT
eurjchem-1748	92	8	and	and	CCONJ
eurjchem-1748	92	9	also	also	ADV
eurjchem-1748	92	10	reactions	reaction	NOUN
eurjchem-1748	92	11	were	be	AUX
eurjchem-1748	92	12	carried	carry	VERB
eurjchem-1748	92	13	out	out	ADP
eurjchem-1748	92	14	with	with	ADP
eurjchem-1748	92	15	10	10	NUM
eurjchem-1748	92	16	or	or	CCONJ
eurjchem-1748	92	17	20	20	NUM
eurjchem-1748	92	18	mol%	mol%	NOUN
eurjchem-1748	92	19	of	of	ADP
eurjchem-1748	92	20	catalyst	catalyst	NOUN
eurjchem-1748	92	21	using	use	VERB
eurjchem-1748	92	22	also	also	ADV
eurjchem-1748	92	23	yields	yield	NOUN
eurjchem-1748	93	1	did	do	AUX
eurjchem-1748	93	2	n’t	not	PART
eurjchem-1748	93	3	change	change	VERB
eurjchem-1748	93	4	appreciably	appreciably	ADV
eurjchem-1748	93	5	.	.	PUNCT
eurjchem-1748	94	1	after	after	ADP
eurjchem-1748	94	2	identifying	identify	VERB
eurjchem-1748	94	3	10	10	NUM
eurjchem-1748	94	4	mol%	mol%	PROPN
eurjchem-1748	94	5	pd(oac)2	pd(oac)2	NOUN
eurjchem-1748	94	6	in	in	ADP
eurjchem-1748	94	7	combination	combination	NOUN
eurjchem-1748	94	8	with	with	ADP
eurjchem-1748	94	9	x	x	NOUN
eurjchem-1748	94	10	-	-	NOUN
eurjchem-1748	94	11	phos	phos	NOUN
eurjchem-1748	94	12	,	,	PUNCT
eurjchem-1748	94	13	k3po4	k3po4	NOUN
eurjchem-1748	94	14	,	,	PUNCT
eurjchem-1748	94	15	thf	thf	NOUN
eurjchem-1748	94	16	and	and	CCONJ
eurjchem-1748	94	17	h2o	h2o	NOUN
eurjchem-1748	94	18	is	be	AUX
eurjchem-1748	94	19	(	(	PUNCT
eurjchem-1748	94	20	4:1	4:1	NUM
eurjchem-1748	94	21	,	,	PUNCT
eurjchem-1748	94	22	v	v	NOUN
eurjchem-1748	94	23	:	:	PUNCT
eurjchem-1748	94	24	v	v	NOUN
eurjchem-1748	94	25	)	)	PUNCT
eurjchem-1748	94	26	,	,	PUNCT
eurjchem-1748	94	27	we	we	PRON
eurjchem-1748	94	28	focused	focus	VERB
eurjchem-1748	94	29	to	to	PART
eurjchem-1748	94	30	increase	increase	VERB
eurjchem-1748	94	31	the	the	DET
eurjchem-1748	94	32	yield	yield	NOUN
eurjchem-1748	94	33	in	in	ADP
eurjchem-1748	94	34	the	the	DET
eurjchem-1748	94	35	c	c	PROPN
eurjchem-1748	94	36	–	–	PUNCT
eurjchem-1748	94	37	c	c	PROPN
eurjchem-1748	94	38	cross	cross	NOUN
eurjchem-1748	94	39	coupling	coupling	NOUN
eurjchem-1748	94	40	reactions	reaction	NOUN
eurjchem-1748	94	41	.	.	PUNCT
eurjchem-1748	95	1	then	then	ADV
eurjchem-1748	95	2	,	,	PUNCT
eurjchem-1748	95	3	we	we	PRON
eurjchem-1748	95	4	performed	perform	VERB
eurjchem-1748	95	5	suzuki	suzuki	PROPN
eurjchem-1748	95	6	coupling	coupling	NOUN
eurjchem-1748	95	7	reactions	reaction	NOUN
eurjchem-1748	95	8	in	in	ADP
eurjchem-1748	95	9	microwave	microwave	NOUN
eurjchem-1748	95	10	instruments	instrument	NOUN
eurjchem-1748	95	11	,	,	PUNCT
eurjchem-1748	95	12	there	there	ADV
eurjchem-1748	95	13	we	we	PRON
eurjchem-1748	95	14	got	get	VERB
eurjchem-1748	95	15	better	well	ADJ
eurjchem-1748	95	16	results	result	NOUN
eurjchem-1748	95	17	.	.	PUNCT
eurjchem-1748	96	1	results	result	NOUN
eurjchem-1748	96	2	from	from	ADP
eurjchem-1748	96	3	our	our	PRON
eurjchem-1748	96	4	initial	initial	ADJ
eurjchem-1748	96	5	investigations	investigation	NOUN
eurjchem-1748	96	6	[	[	X
eurjchem-1748	96	7	29	29	NUM
eurjchem-1748	96	8	]	]	PUNCT
eurjchem-1748	96	9	by	by	ADP
eurjchem-1748	96	10	using	use	VERB
eurjchem-1748	96	11	ligand	ligand	NOUN
eurjchem-1748	96	12	are	be	AUX
eurjchem-1748	96	13	shown	show	VERB
eurjchem-1748	96	14	in	in	ADP
eurjchem-1748	96	15	table	table	NOUN
eurjchem-1748	96	16	1	1	NUM
eurjchem-1748	96	17	.	.	PUNCT
eurjchem-1748	96	18	2.2	2.2	NUM
eurjchem-1748	96	19	.	.	PUNCT
eurjchem-1748	97	1	molecular	molecular	ADJ
eurjchem-1748	97	2	modelling	modelling	NOUN
eurjchem-1748	97	3	and	and	CCONJ
eurjchem-1748	97	4	drug	drug	NOUN
eurjchem-1748	97	5	design	design	NOUN
eurjchem-1748	97	6	molecular	molecular	ADJ
eurjchem-1748	97	7	modeling	modeling	NOUN
eurjchem-1748	97	8	and	and	CCONJ
eurjchem-1748	97	9	analysis	analysis	NOUN
eurjchem-1748	97	10	:	:	PUNCT
eurjchem-1748	97	11	the	the	DET
eurjchem-1748	97	12	binding	bind	VERB
eurjchem-1748	97	13	mode	mode	NOUN
eurjchem-1748	97	14	of	of	ADP
eurjchem-1748	97	15	the	the	DET
eurjchem-1748	97	16	compounds	compound	NOUN
eurjchem-1748	97	17	at	at	ADP
eurjchem-1748	97	18	the	the	DET
eurjchem-1748	97	19	active	active	ADJ
eurjchem-1748	97	20	site	site	NOUN
eurjchem-1748	97	21	of	of	ADP
eurjchem-1748	97	22	a	a	DET
eurjchem-1748	97	23	-	-	PUNCT
eurjchem-1748	97	24	glucosidase	glucosidase	NOUN
eurjchem-1748	97	25	was	be	AUX
eurjchem-1748	97	26	explored	explore	VERB
eurjchem-1748	97	27	using	use	VERB
eurjchem-1748	97	28	glide	glide	NOUN
eurjchem-1748	97	29	in	in	ADP
eurjchem-1748	97	30	-	-	PUNCT
eurjchem-1748	97	31	silico	silico	NOUN
eurjchem-1748	97	32	protocol	protocol	NOUN
eurjchem-1748	97	33	(	(	PUNCT
eurjchem-1748	97	34	schrödinger	schrödinger	ADJ
eurjchem-1748	97	35	software	software	NOUN
eurjchem-1748	97	36	package	package	NOUN
eurjchem-1748	97	37	maestro	maestro	VERB
eurjchem-1748	97	38	2017	2017	NUM
eurjchem-1748	97	39	-	-	SYM
eurjchem-1748	97	40	2	2	NUM
eurjchem-1748	97	41	(	(	PUNCT
eurjchem-1748	97	42	glide	glide	ADJ
eurjchem-1748	97	43	,	,	PUNCT
eurjchem-1748	97	44	schrödinger	schrödinger	NOUN
eurjchem-1748	97	45	,	,	PUNCT
eurjchem-1748	97	46	llc	llc	PROPN
eurjchem-1748	97	47	,	,	PUNCT
eurjchem-1748	97	48	new	new	PROPN
eurjchem-1748	97	49	york	york	PROPN
eurjchem-1748	97	50	,	,	PUNCT
eurjchem-1748	97	51	ny	ny	PROPN
eurjchem-1748	97	52	,	,	PUNCT
eurjchem-1748	97	53	2017	2017	NUM
eurjchem-1748	97	54	)	)	PUNCT
eurjchem-1748	97	55	.	.	PUNCT
eurjchem-1748	98	1	a	a	DET
eurjchem-1748	98	2	search	search	NOUN
eurjchem-1748	98	3	of	of	ADP
eurjchem-1748	98	4	a	a	DET
eurjchem-1748	98	5	3d	3d	NUM
eurjchem-1748	98	6	database	database	NOUN
eurjchem-1748	98	7	(	(	PUNCT
eurjchem-1748	98	8	gostar	gostar	NOUN
eurjchem-1748	98	9	)	)	PUNCT
eurjchem-1748	98	10	we	we	PRON
eurjchem-1748	98	11	prioritized	prioritize	VERB
eurjchem-1748	98	12	the	the	DET
eurjchem-1748	98	13	synthesis	synthesis	NOUN
eurjchem-1748	98	14	molecules	molecule	NOUN
eurjchem-1748	98	15	.	.	PUNCT
eurjchem-1748	99	1	the	the	DET
eurjchem-1748	99	2	pdb	pdb	PROPN
eurjchem-1748	99	3	i	i	PROPN
eurjchem-1748	99	4	d	d	PROPN
eurjchem-1748	99	5	3wy1	3wy1	NUM
eurjchem-1748	99	6	was	be	AUX
eurjchem-1748	99	7	used	use	VERB
eurjchem-1748	99	8	for	for	ADP
eurjchem-1748	99	9	docking	dock	VERB
eurjchem-1748	99	10	study	study	NOUN
eurjchem-1748	99	11	which	which	PRON
eurjchem-1748	99	12	was	be	AUX
eurjchem-1748	99	13	downloaded	download	VERB
eurjchem-1748	99	14	from	from	ADP
eurjchem-1748	99	15	protein	protein	NOUN
eurjchem-1748	99	16	data	datum	NOUN
eurjchem-1748	99	17	bank	bank	NOUN
eurjchem-1748	99	18	(	(	PUNCT
eurjchem-1748	99	19	www.rcsb.org	www.rcsb.org	X
eurjchem-1748	99	20	)	)	PUNCT
eurjchem-1748	99	21	.	.	PUNCT
eurjchem-1748	100	1	ligand	ligand	PROPN
eurjchem-1748	100	2	preparation	preparation	NOUN
eurjchem-1748	100	3	:	:	PUNCT
eurjchem-1748	100	4	all	all	DET
eurjchem-1748	100	5	ligands	ligand	NOUN
eurjchem-1748	100	6	were	be	AUX
eurjchem-1748	100	7	drew	draw	VERB
eurjchem-1748	100	8	by	by	ADP
eurjchem-1748	100	9	using	use	VERB
eurjchem-1748	100	10	maestro	maestro	NOUN
eurjchem-1748	100	11	(	(	PUNCT
eurjchem-1748	100	12	schrödinger	schrödinger	ADJ
eurjchem-1748	100	13	software	software	NOUN
eurjchem-1748	100	14	)	)	PUNCT
eurjchem-1748	100	15	and	and	CCONJ
eurjchem-1748	100	16	prepared	prepare	VERB
eurjchem-1748	100	17	for	for	ADP
eurjchem-1748	100	18	docking	docking	NOUN
eurjchem-1748	100	19	by	by	ADP
eurjchem-1748	100	20	ligprep	ligprep	PROPN
eurjchem-1748	100	21	module	module	NOUN
eurjchem-1748	100	22	(	(	PUNCT
eurjchem-1748	100	23	ligprep	ligprep	PROPN
eurjchem-1748	100	24	,	,	PUNCT
eurjchem-1748	100	25	schrödinger	schrödinger	NOUN
eurjchem-1748	100	26	,	,	PUNCT
eurjchem-1748	100	27	llc	llc	PROPN
eurjchem-1748	100	28	,	,	PUNCT
eurjchem-1748	100	29	new	new	PROPN
eurjchem-1748	100	30	york	york	PROPN
eurjchem-1748	100	31	,	,	PUNCT
eurjchem-1748	100	32	ny	ny	PROPN
eurjchem-1748	100	33	,	,	PUNCT
eurjchem-1748	100	34	2017	2017	NUM
eurjchem-1748	100	35	)	)	PUNCT
eurjchem-1748	100	36	.	.	PUNCT
eurjchem-1748	101	1	2018	2018	NUM
eurjchem-1748	101	2	–	–	PUNCT
eurjchem-1748	101	3	european	european	ADJ
eurjchem-1748	101	4	journal	journal	NOUN
eurjchem-1748	101	5	of	of	ADP
eurjchem-1748	101	6	chemistry	chemistry	NOUN
eurjchem-1748	101	7	–	–	PUNCT
eurjchem-1748	101	8	cc	cc	NOUN
eurjchem-1748	101	9	by	by	ADP
eurjchem-1748	101	10	nc	nc	PROPN
eurjchem-1748	101	11	–	–	PUNCT
eurjchem-1748	101	12	doi	doi	PROPN
eurjchem-1748	101	13	:	:	PUNCT
eurjchem-1748	101	14	10.5155	10.5155	NUM
eurjchem-1748	101	15	/	/	SYM
eurjchem-1748	101	16	eurjchem.9.4.322	eurjchem.9.4.322	PROPN
eurjchem-1748	101	17	-	-	PUNCT
eurjchem-1748	101	18	330.1748	330.1748	NUM
eurjchem-1748	101	19	http://www.rcsb.org/	http://www.rcsb.org/	NOUN
eurjchem-1748	101	20	ankireddy	ankireddy	PROPN
eurjchem-1748	101	21	et	et	PROPN
eurjchem-1748	101	22	al	al	PROPN
eurjchem-1748	101	23	.	.	PUNCT
eurjchem-1748	101	24	/	/	SYM
eurjchem-1748	101	25	european	european	PROPN
eurjchem-1748	101	26	journal	journal	PROPN
eurjchem-1748	101	27	of	of	ADP
eurjchem-1748	101	28	chemistry	chemistry	NOUN
eurjchem-1748	101	29	9	9	NUM
eurjchem-1748	101	30	(	(	PUNCT
eurjchem-1748	101	31	4	4	NUM
eurjchem-1748	101	32	)	)	PUNCT
eurjchem-1748	101	33	(	(	PUNCT
eurjchem-1748	101	34	2018	2018	NUM
eurjchem-1748	101	35	)	)	PUNCT
eurjchem-1748	101	36	322	322	NUM
eurjchem-1748	101	37	-	-	SYM
eurjchem-1748	101	38	330	330	NUM
eurjchem-1748	101	39	325	325	NUM
eurjchem-1748	101	40	table	table	NOUN
eurjchem-1748	101	41	1	1	NUM
eurjchem-1748	101	42	.	.	PUNCT
eurjchem-1748	101	43	evaluation	evaluation	NOUN
eurjchem-1748	101	44	of	of	ADP
eurjchem-1748	101	45	the	the	DET
eurjchem-1748	101	46	scope	scope	NOUN
eurjchem-1748	101	47	of	of	ADP
eurjchem-1748	101	48	c	c	PROPN
eurjchem-1748	101	49	–	–	PUNCT
eurjchem-1748	101	50	c	c	NOUN
eurjchem-1748	101	51	coupling	coupling	NOUN
eurjchem-1748	101	52	reactions	reaction	NOUN
eurjchem-1748	101	53	of	of	ADP
eurjchem-1748	101	54	various	various	ADJ
eurjchem-1748	101	55	boronic	boronic	ADJ
eurjchem-1748	101	56	acids	acid	NOUN
eurjchem-1748	101	57	with	with	ADP
eurjchem-1748	101	58	7	7	NUM
eurjchem-1748	101	59	-	-	PUNCT
eurjchem-1748	101	60	chloro-2	chloro-2	NUM
eurjchem-1748	101	61	-	-	PUNCT
eurjchem-1748	101	62	morpholino	morpholino	NOUN
eurjchem-1748	101	63	-	-	PUNCT
eurjchem-1748	101	64	n-(pyridin-2	n-(pyridin-2	NUM
eurjchem-1748	101	65	-	-	PUNCT
eurjchem-1748	101	66	ylmethyl)quinazolin-4	ylmethyl)quinazolin-4	NOUN
eurjchem-1748	101	67	-	-	PUNCT
eurjchem-1748	101	68	amine	amine	NOUN
eurjchem-1748	101	69	by	by	ADP
eurjchem-1748	101	70	using	use	VERB
eurjchem-1748	101	71	ligand	ligand	PROPN
eurjchem-1748	101	72	(	(	PUNCT
eurjchem-1748	101	73	l3	l3	PROPN
eurjchem-1748	101	74	)	)	PUNCT
eurjchem-1748	101	75	(	(	PUNCT
eurjchem-1748	101	76	scheme	scheme	NOUN
eurjchem-1748	101	77	2	2	NUM
eurjchem-1748	101	78	)	)	PUNCT
eurjchem-1748	101	79	*	*	PUNCT
eurjchem-1748	101	80	.	.	PUNCT
eurjchem-1748	102	1	molecule	molecule	NOUN
eurjchem-1748	102	2	number	number	NOUN
eurjchem-1748	102	3	boronic	boronic	NOUN
eurjchem-1748	102	4	acid	acid	NOUN
eurjchem-1748	102	5	derivative	derivative	ADJ
eurjchem-1748	102	6	yield	yield	NOUN
eurjchem-1748	102	7	(	(	PUNCT
eurjchem-1748	102	8	%	%	INTJ
eurjchem-1748	102	9	)	)	PUNCT
eurjchem-1748	102	10	k3po4	k3po4	NOUN
eurjchem-1748	102	11	,	,	PUNCT
eurjchem-1748	102	12	thf	thf	NOUN
eurjchem-1748	102	13	:	:	PUNCT
eurjchem-1748	102	14	h2o	h2o	PROPN
eurjchem-1748	102	15	(	(	PUNCT
eurjchem-1748	102	16	4:1	4:1	NUM
eurjchem-1748	102	17	)	)	PUNCT
eurjchem-1748	102	18	,	,	PUNCT
eurjchem-1748	102	19	microwave	microwave	NOUN
eurjchem-1748	102	20	,	,	PUNCT
eurjchem-1748	102	21	120	120	NUM
eurjchem-1748	102	22	°	°	NOUN
eurjchem-1748	102	23	c	c	NOUN
eurjchem-1748	102	24	,	,	PUNCT
eurjchem-1748	102	25	30	30	NUM
eurjchem-1748	102	26	min	min	NOUN
eurjchem-1748	102	27	,	,	PUNCT
eurjchem-1748	102	28	k3po4	k3po4	NOUN
eurjchem-1748	102	29	,	,	PUNCT
eurjchem-1748	102	30	thf	thf	NOUN
eurjchem-1748	102	31	:	:	PUNCT
eurjchem-1748	102	32	h2o	h2o	PROPN
eurjchem-1748	102	33	(	(	PUNCT
eurjchem-1748	102	34	4:1	4:1	NUM
eurjchem-1748	102	35	)	)	PUNCT
eurjchem-1748	102	36	,	,	PUNCT
eurjchem-1748	102	37	sealed	seal	VERB
eurjchem-1748	102	38	tube	tube	NOUN
eurjchem-1748	102	39	,	,	PUNCT
eurjchem-1748	102	40	100	100	NUM
eurjchem-1748	102	41	°	°	NOUN
eurjchem-1748	102	42	c	c	NOUN
eurjchem-1748	102	43	,	,	PUNCT
eurjchem-1748	102	44	60	60	NUM
eurjchem-1748	102	45	min	min	NOUN
eurjchem-1748	102	46	k3po4	k3po4	NOUN
eurjchem-1748	102	47	,	,	PUNCT
eurjchem-1748	102	48	thf	thf	NOUN
eurjchem-1748	102	49	:	:	PUNCT
eurjchem-1748	102	50	h2o	h2o	PROPN
eurjchem-1748	102	51	(	(	PUNCT
eurjchem-1748	102	52	4:1	4:1	NUM
eurjchem-1748	102	53	)	)	PUNCT
eurjchem-1748	102	54	,	,	PUNCT
eurjchem-1748	102	55	conventional	conventional	ADJ
eurjchem-1748	102	56	,	,	PUNCT
eurjchem-1748	102	57	80	80	NUM
eurjchem-1748	102	58	°	°	NOUN
eurjchem-1748	102	59	c	c	NOUN
eurjchem-1748	102	60	,	,	PUNCT
eurjchem-1748	102	61	16	16	NUM
eurjchem-1748	102	62	h	h	NOUN
eurjchem-1748	102	63	8	8	NUM
eurjchem-1748	102	64	b	b	X
eurjchem-1748	103	1	oh	oh	INTJ
eurjchem-1748	103	2	oh	oh	INTJ
eurjchem-1748	103	3	80	80	NUM
eurjchem-1748	103	4	60	60	NUM
eurjchem-1748	103	5	30	30	NUM
eurjchem-1748	103	6	9	9	NUM
eurjchem-1748	103	7	b	b	X
eurjchem-1748	103	8	ch3	ch3	PROPN
eurjchem-1748	104	1	oh	oh	INTJ
eurjchem-1748	104	2	oh	oh	INTJ
eurjchem-1748	104	3	65	65	NUM
eurjchem-1748	104	4	42	42	NUM
eurjchem-1748	104	5	21	21	NUM
eurjchem-1748	104	6	10	10	NUM
eurjchem-1748	104	7	b	b	NOUN
eurjchem-1748	104	8	f	f	NOUN
eurjchem-1748	105	1	oh	oh	INTJ
eurjchem-1748	105	2	oh	oh	INTJ
eurjchem-1748	105	3	77	77	NUM
eurjchem-1748	106	1	53	53	NUM
eurjchem-1748	106	2	13	13	NUM
eurjchem-1748	106	3	11	11	NUM
eurjchem-1748	106	4	b	b	NOUN
eurjchem-1748	106	5	och3	och3	ADJ
eurjchem-1748	107	1	oh	oh	INTJ
eurjchem-1748	107	2	oh	oh	INTJ
eurjchem-1748	107	3	62	62	NUM
eurjchem-1748	107	4	35	35	NUM
eurjchem-1748	107	5	20	20	NUM
eurjchem-1748	107	6	12	12	NUM
eurjchem-1748	107	7	b	b	NOUN
eurjchem-1748	107	8	h3co	h3co	NOUN
eurjchem-1748	108	1	oh	oh	INTJ
eurjchem-1748	108	2	oh	oh	INTJ
eurjchem-1748	108	3	66	66	NUM
eurjchem-1748	109	1	41	41	NUM
eurjchem-1748	109	2	22	22	NUM
eurjchem-1748	109	3	13	13	NUM
eurjchem-1748	109	4	b	b	NOUN
eurjchem-1748	110	1	oh	oh	INTJ
eurjchem-1748	110	2	oh	oh	INTJ
eurjchem-1748	110	3	67	67	NUM
eurjchem-1748	110	4	54	54	NUM
eurjchem-1748	110	5	18	18	NUM
eurjchem-1748	110	6	14	14	NUM
eurjchem-1748	110	7	bh3co	bh3co	NOUN
eurjchem-1748	111	1	oh	oh	INTJ
eurjchem-1748	111	2	oh	oh	INTJ
eurjchem-1748	111	3	75	75	NUM
eurjchem-1748	111	4	35	35	NUM
eurjchem-1748	111	5	15	15	NUM
eurjchem-1748	111	6	15	15	NUM
eurjchem-1748	111	7	bh3co	bh3co	NOUN
eurjchem-1748	112	1	h3co	h3co	PUNCT
eurjchem-1748	113	1	oh	oh	INTJ
eurjchem-1748	113	2	oh	oh	INTJ
eurjchem-1748	113	3	65	65	NUM
eurjchem-1748	114	1	65	65	NUM
eurjchem-1748	114	2	17	17	NUM
eurjchem-1748	114	3	16	16	NUM
eurjchem-1748	114	4	b	b	X
eurjchem-1748	114	5	nc	nc	PROPN
eurjchem-1748	115	1	oh	oh	INTJ
eurjchem-1748	115	2	oh	oh	INTJ
eurjchem-1748	115	3	75	75	NUM
eurjchem-1748	115	4	25	25	NUM
eurjchem-1748	115	5	14	14	NUM
eurjchem-1748	115	6	17	17	NUM
eurjchem-1748	115	7	b	b	NOUN
eurjchem-1748	116	1	oh	oh	INTJ
eurjchem-1748	116	2	oh	oh	INTJ
eurjchem-1748	116	3	67	67	NUM
eurjchem-1748	116	4	40	40	NUM
eurjchem-1748	116	5	5	5	NUM
eurjchem-1748	116	6	18	18	NUM
eurjchem-1748	116	7	b	b	NUM
eurjchem-1748	116	8	nh	nh	INTJ
eurjchem-1748	117	1	oh	oh	INTJ
eurjchem-1748	117	2	oh	oh	INTJ
eurjchem-1748	117	3	81	81	NUM
eurjchem-1748	117	4	55	55	NUM
eurjchem-1748	117	5	6	6	NUM
eurjchem-1748	117	6	19	19	NUM
eurjchem-1748	117	7	bo	bo	NOUN
eurjchem-1748	117	8	o	o	NOUN
eurjchem-1748	118	1	oh	oh	INTJ
eurjchem-1748	118	2	oh	oh	INTJ
eurjchem-1748	118	3	88	88	NUM
eurjchem-1748	118	4	65	65	NUM
eurjchem-1748	118	5	11	11	NUM
eurjchem-1748	118	6	20	20	NUM
eurjchem-1748	118	7	nh	nh	NOUN
eurjchem-1748	118	8	bho	bho	NOUN
eurjchem-1748	119	1	oh	oh	INTJ
eurjchem-1748	119	2	81	81	NUM
eurjchem-1748	119	3	61	61	NUM
eurjchem-1748	119	4	16	16	NUM
eurjchem-1748	119	5	21	21	NUM
eurjchem-1748	119	6	bnc	bnc	NOUN
eurjchem-1748	120	1	oh	oh	INTJ
eurjchem-1748	120	2	oh	oh	INTJ
eurjchem-1748	120	3	75	75	NUM
eurjchem-1748	121	1	60	60	NUM
eurjchem-1748	121	2	5	5	NUM
eurjchem-1748	121	3	22	22	NUM
eurjchem-1748	121	4	b	b	NOUN
eurjchem-1748	121	5	cooh	cooh	NOUN
eurjchem-1748	122	1	oh	oh	INTJ
eurjchem-1748	122	2	oh	oh	INTJ
eurjchem-1748	122	3	88	88	NUM
eurjchem-1748	122	4	55	55	NUM
eurjchem-1748	122	5	7	7	NUM
eurjchem-1748	122	6	23	23	NUM
eurjchem-1748	122	7	b	b	NOUN
eurjchem-1748	123	1	oh	oh	INTJ
eurjchem-1748	123	2	oh	oh	INTJ
eurjchem-1748	123	3	75	75	NUM
eurjchem-1748	123	4	58	58	NUM
eurjchem-1748	123	5	15	15	NUM
eurjchem-1748	123	6	24	24	NUM
eurjchem-1748	123	7	b	b	NOUN
eurjchem-1748	124	1	oh	oh	INTJ
eurjchem-1748	124	2	oh	oh	INTJ
eurjchem-1748	124	3	71	71	NUM
eurjchem-1748	124	4	41	41	NUM
eurjchem-1748	124	5	8	8	NUM
eurjchem-1748	124	6	25	25	NUM
eurjchem-1748	124	7	o	o	NOUN
eurjchem-1748	124	8	b	b	NOUN
eurjchem-1748	124	9	ho	ho	INTJ
eurjchem-1748	125	1	oh	oh	INTJ
eurjchem-1748	125	2	69	69	NUM
eurjchem-1748	125	3	55	55	NUM
eurjchem-1748	125	4	4	4	NUM
eurjchem-1748	125	5	26	26	NUM
eurjchem-1748	125	6	b	b	NOUN
eurjchem-1748	125	7	h3c	h3c	VERB
eurjchem-1748	125	8	nh2	nh2	PROPN
eurjchem-1748	126	1	oh	oh	INTJ
eurjchem-1748	127	1	oh	oh	INTJ
eurjchem-1748	127	2	75	75	NUM
eurjchem-1748	127	3	45	45	NUM
eurjchem-1748	127	4	12	12	NUM
eurjchem-1748	127	5	27	27	NUM
eurjchem-1748	127	6	b	b	NOUN
eurjchem-1748	127	7	h3co	h3co	X
eurjchem-1748	127	8	och3	och3	ADJ
eurjchem-1748	128	1	oh	oh	INTJ
eurjchem-1748	128	2	oh	oh	INTJ
eurjchem-1748	128	3	70	70	NUM
eurjchem-1748	128	4	44	44	NUM
eurjchem-1748	128	5	15	15	NUM
eurjchem-1748	128	6	*	*	PUNCT
eurjchem-1748	128	7	all	all	DET
eurjchem-1748	128	8	reactions	reaction	NOUN
eurjchem-1748	128	9	were	be	AUX
eurjchem-1748	128	10	carried	carry	VERB
eurjchem-1748	128	11	out	out	ADP
eurjchem-1748	128	12	in	in	ADP
eurjchem-1748	128	13	10	10	NUM
eurjchem-1748	128	14	mg	mg	PROPN
eurjchem-1748	128	15	scale	scale	NOUN
eurjchem-1748	128	16	initially	initially	ADV
eurjchem-1748	128	17	.	.	PUNCT
eurjchem-1748	129	1	after	after	ADP
eurjchem-1748	129	2	succeeding	succeed	VERB
eurjchem-1748	129	3	the	the	DET
eurjchem-1748	129	4	product	product	NOUN
eurjchem-1748	129	5	formation	formation	NOUN
eurjchem-1748	129	6	in	in	ADP
eurjchem-1748	129	7	pd(oac)2	pd(oac)2	NOUN
eurjchem-1748	129	8	,	,	PUNCT
eurjchem-1748	129	9	x	x	NOUN
eurjchem-1748	129	10	-	-	NOUN
eurjchem-1748	129	11	phos	phos	NOUN
eurjchem-1748	129	12	,	,	PUNCT
eurjchem-1748	129	13	k3po4	k3po4	NOUN
eurjchem-1748	129	14	,	,	PUNCT
eurjchem-1748	129	15	thf	thf	NOUN
eurjchem-1748	129	16	:	:	PUNCT
eurjchem-1748	129	17	h2o	h2o	PROPN
eurjchem-1748	129	18	(	(	PUNCT
eurjchem-1748	129	19	4:1	4:1	NUM
eurjchem-1748	129	20	,	,	PUNCT
eurjchem-1748	129	21	v	v	NOUN
eurjchem-1748	129	22	:	:	PUNCT
eurjchem-1748	129	23	v	v	NOUN
eurjchem-1748	129	24	)	)	PUNCT
eurjchem-1748	129	25	,	,	PUNCT
eurjchem-1748	129	26	then	then	ADV
eurjchem-1748	129	27	we	we	PRON
eurjchem-1748	129	28	focused	focus	VERB
eurjchem-1748	129	29	to	to	PART
eurjchem-1748	129	30	increase	increase	VERB
eurjchem-1748	129	31	the	the	DET
eurjchem-1748	129	32	yields	yield	NOUN
eurjchem-1748	129	33	.	.	PUNCT
eurjchem-1748	130	1	reactions	reaction	NOUN
eurjchem-1748	130	2	were	be	AUX
eurjchem-1748	130	3	initially	initially	ADV
eurjchem-1748	130	4	carried	carry	VERB
eurjchem-1748	130	5	out	out	ADP
eurjchem-1748	130	6	in	in	ADP
eurjchem-1748	130	7	conventional	conventional	ADJ
eurjchem-1748	130	8	method	method	NOUN
eurjchem-1748	130	9	.	.	PUNCT
eurjchem-1748	131	1	the	the	DET
eurjchem-1748	131	2	yields	yield	NOUN
eurjchem-1748	131	3	were	be	AUX
eurjchem-1748	131	4	gradually	gradually	ADV
eurjchem-1748	131	5	increased	increase	VERB
eurjchem-1748	131	6	when	when	SCONJ
eurjchem-1748	131	7	we	we	PRON
eurjchem-1748	131	8	changed	change	VERB
eurjchem-1748	131	9	from	from	ADP
eurjchem-1748	131	10	conventional	conventional	ADJ
eurjchem-1748	131	11	to	to	ADP
eurjchem-1748	131	12	sealed	seal	VERB
eurjchem-1748	131	13	tube	tube	NOUN
eurjchem-1748	131	14	.	.	PUNCT
eurjchem-1748	132	1	finally	finally	ADV
eurjchem-1748	132	2	the	the	DET
eurjchem-1748	132	3	yields	yield	NOUN
eurjchem-1748	132	4	were	be	AUX
eurjchem-1748	132	5	much	much	ADV
eurjchem-1748	132	6	better	well	ADJ
eurjchem-1748	132	7	when	when	SCONJ
eurjchem-1748	132	8	we	we	PRON
eurjchem-1748	132	9	used	use	VERB
eurjchem-1748	132	10	microwave	microwave	NOUN
eurjchem-1748	132	11	120	120	NUM
eurjchem-1748	133	1	°	°	NOUN
eurjchem-1748	133	2	c	c	NOUN
eurjchem-1748	133	3	,	,	PUNCT
eurjchem-1748	133	4	30	30	NUM
eurjchem-1748	133	5	min	min	NOUN
eurjchem-1748	133	6	.	.	PROPN
eurjchem-1748	133	7	best	good	ADJ
eurjchem-1748	133	8	yields	yield	NOUN
eurjchem-1748	133	9	were	be	AUX
eurjchem-1748	133	10	observed	observe	VERB
eurjchem-1748	133	11	for	for	ADP
eurjchem-1748	133	12	compound	compound	NOUN
eurjchem-1748	133	13	19	19	NUM
eurjchem-1748	133	14	and	and	CCONJ
eurjchem-1748	133	15	22	22	NUM
eurjchem-1748	133	16	.	.	X
eurjchem-1748	134	1	2018	2018	NUM
eurjchem-1748	134	2	–	–	PUNCT
eurjchem-1748	134	3	european	european	ADJ
eurjchem-1748	134	4	journal	journal	NOUN
eurjchem-1748	134	5	of	of	ADP
eurjchem-1748	134	6	chemistry	chemistry	NOUN
eurjchem-1748	134	7	–	–	PUNCT
eurjchem-1748	134	8	cc	cc	NOUN
eurjchem-1748	134	9	by	by	ADP
eurjchem-1748	134	10	nc	nc	PROPN
eurjchem-1748	134	11	–	–	PUNCT
eurjchem-1748	134	12	doi	doi	PROPN
eurjchem-1748	134	13	:	:	PUNCT
eurjchem-1748	134	14	10.5155	10.5155	NUM
eurjchem-1748	134	15	/	/	SYM
eurjchem-1748	134	16	eurjchem.9.4.322	eurjchem.9.4.322	PROPN
eurjchem-1748	134	17	-	-	PUNCT
eurjchem-1748	134	18	330.1748	330.1748	NUM
eurjchem-1748	134	19	326	326	NUM
eurjchem-1748	134	20	ankireddy	ankireddy	ADV
eurjchem-1748	134	21	et	et	PROPN
eurjchem-1748	134	22	al	al	PROPN
eurjchem-1748	134	23	.	.	PUNCT
eurjchem-1748	134	24	/	/	SYM
eurjchem-1748	134	25	european	european	PROPN
eurjchem-1748	134	26	journal	journal	PROPN
eurjchem-1748	134	27	of	of	ADP
eurjchem-1748	134	28	chemistry	chemistry	NOUN
eurjchem-1748	134	29	9	9	NUM
eurjchem-1748	134	30	(	(	PUNCT
eurjchem-1748	134	31	4	4	NUM
eurjchem-1748	134	32	)	)	PUNCT
eurjchem-1748	134	33	(	(	PUNCT
eurjchem-1748	134	34	2018	2018	NUM
eurjchem-1748	134	35	)	)	PUNCT
eurjchem-1748	134	36	322	322	NUM
eurjchem-1748	134	37	-	-	SYM
eurjchem-1748	134	38	330	330	NUM
eurjchem-1748	134	39	scheme	scheme	NOUN
eurjchem-1748	134	40	2	2	NUM
eurjchem-1748	134	41	.	.	PUNCT
eurjchem-1748	134	42	synthesis	synthesis	NOUN
eurjchem-1748	134	43	of	of	ADP
eurjchem-1748	134	44	7	7	NUM
eurjchem-1748	134	45	-	-	PUNCT
eurjchem-1748	134	46	substituted	substitute	VERB
eurjchem-1748	134	47	quinazoline	quinazoline	NOUN
eurjchem-1748	134	48	compounds	compound	NOUN
eurjchem-1748	134	49	.	.	PUNCT
eurjchem-1748	135	1	the	the	DET
eurjchem-1748	135	2	docking	docking	NOUN
eurjchem-1748	135	3	in	in	ADP
eurjchem-1748	135	4	-	-	PUNCT
eurjchem-1748	135	5	silico	silico	NOUN
eurjchem-1748	135	6	experiments	experiment	NOUN
eurjchem-1748	135	7	were	be	AUX
eurjchem-1748	135	8	performed	perform	VERB
eurjchem-1748	135	9	through	through	ADP
eurjchem-1748	135	10	glide	glide	NOUN
eurjchem-1748	135	11	(	(	PUNCT
eurjchem-1748	135	12	grid	grid	NOUN
eurjchem-1748	135	13	based	base	VERB
eurjchem-1748	135	14	ligand	ligand	NOUN
eurjchem-1748	135	15	docking	docking	NOUN
eurjchem-1748	135	16	with	with	ADP
eurjchem-1748	135	17	energetics	energetic	NOUN
eurjchem-1748	135	18	)	)	PUNCT
eurjchem-1748	135	19	program	program	NOUN
eurjchem-1748	135	20	in	in	ADP
eurjchem-1748	135	21	schrödinger	schrödinger	ADJ
eurjchem-1748	135	22	software	software	NOUN
eurjchem-1748	135	23	(	(	PUNCT
eurjchem-1748	135	24	maestro	maestro	NOUN
eurjchem-1748	135	25	)	)	PUNCT
eurjchem-1748	135	26	suite	suite	NOUN
eurjchem-1748	135	27	.	.	PUNCT
eurjchem-1748	136	1	in	in	ADP
eurjchem-1748	136	2	glide	glide	NOUN
eurjchem-1748	136	3	,	,	PUNCT
eurjchem-1748	136	4	the	the	DET
eurjchem-1748	136	5	initial	initial	ADJ
eurjchem-1748	136	6	filters	filter	NOUN
eurjchem-1748	136	7	test	test	VERB
eurjchem-1748	136	8	the	the	DET
eurjchem-1748	136	9	spatial	spatial	ADJ
eurjchem-1748	136	10	fit	fit	NOUN
eurjchem-1748	136	11	of	of	ADP
eurjchem-1748	136	12	the	the	DET
eurjchem-1748	136	13	ligand	ligand	NOUN
eurjchem-1748	136	14	to	to	ADP
eurjchem-1748	136	15	the	the	DET
eurjchem-1748	136	16	defined	define	VERB
eurjchem-1748	136	17	active	active	ADJ
eurjchem-1748	136	18	site	site	NOUN
eurjchem-1748	136	19	and	and	CCONJ
eurjchem-1748	136	20	examine	examine	VERB
eurjchem-1748	136	21	the	the	DET
eurjchem-1748	136	22	complementarity	complementarity	NOUN
eurjchem-1748	136	23	of	of	ADP
eurjchem-1748	136	24	ligandreceptor	ligandreceptor	NOUN
eurjchem-1748	136	25	interactions	interaction	NOUN
eurjchem-1748	136	26	using	use	VERB
eurjchem-1748	136	27	a	a	DET
eurjchem-1748	136	28	grid	grid	NOUN
eurjchem-1748	136	29	-	-	PUNCT
eurjchem-1748	136	30	based	base	VERB
eurjchem-1748	136	31	method	method	NOUN
eurjchem-1748	136	32	patterned	pattern	VERB
eurjchem-1748	136	33	after	after	ADP
eurjchem-1748	136	34	the	the	DET
eurjchem-1748	136	35	empirical	empirical	ADJ
eurjchem-1748	136	36	chemscore	chemscore	NOUN
eurjchem-1748	136	37	function	function	NOUN
eurjchem-1748	136	38	.	.	PUNCT
eurjchem-1748	137	1	poses	pose	NOUN
eurjchem-1748	137	2	that	that	PRON
eurjchem-1748	137	3	pass	pass	VERB
eurjchem-1748	137	4	these	these	DET
eurjchem-1748	137	5	initial	initial	ADJ
eurjchem-1748	137	6	screens	screen	NOUN
eurjchem-1748	137	7	enter	enter	VERB
eurjchem-1748	137	8	the	the	DET
eurjchem-1748	137	9	final	final	ADJ
eurjchem-1748	137	10	stage	stage	NOUN
eurjchem-1748	137	11	of	of	ADP
eurjchem-1748	137	12	the	the	DET
eurjchem-1748	137	13	algorithm	algorithm	NOUN
eurjchem-1748	137	14	,	,	PUNCT
eurjchem-1748	137	15	which	which	PRON
eurjchem-1748	137	16	involves	involve	VERB
eurjchem-1748	137	17	evaluation	evaluation	NOUN
eurjchem-1748	137	18	and	and	CCONJ
eurjchem-1748	137	19	minimization	minimization	NOUN
eurjchem-1748	137	20	of	of	ADP
eurjchem-1748	137	21	a	a	DET
eurjchem-1748	137	22	grid	grid	NOUN
eurjchem-1748	137	23	approximation	approximation	NOUN
eurjchem-1748	137	24	to	to	ADP
eurjchem-1748	137	25	the	the	DET
eurjchem-1748	137	26	opls	opls	PROPN
eurjchem-1748	137	27	-	-	PUNCT
eurjchem-1748	137	28	aa	aa	ADJ
eurjchem-1748	137	29	non	non	ADJ
eurjchem-1748	137	30	-	-	ADJ
eurjchem-1748	137	31	bonded	bond	VERB
eurjchem-1748	137	32	ligand	ligand	NOUN
eurjchem-1748	137	33	-	-	PUNCT
eurjchem-1748	137	34	receptor	receptor	NOUN
eurjchem-1748	137	35	interaction	interaction	NOUN
eurjchem-1748	137	36	energy	energy	NOUN
eurjchem-1748	137	37	.	.	PUNCT
eurjchem-1748	138	1	final	final	ADJ
eurjchem-1748	138	2	scoring	scoring	NOUN
eurjchem-1748	138	3	was	be	AUX
eurjchem-1748	138	4	then	then	ADV
eurjchem-1748	138	5	carried	carry	VERB
eurjchem-1748	138	6	out	out	ADP
eurjchem-1748	138	7	on	on	ADP
eurjchem-1748	138	8	the	the	DET
eurjchem-1748	138	9	energyminimized	energyminimize	VERB
eurjchem-1748	138	10	poses	pose	NOUN
eurjchem-1748	138	11	.	.	PUNCT
eurjchem-1748	139	1	by	by	ADP
eurjchem-1748	139	2	default	default	NOUN
eurjchem-1748	139	3	,	,	PUNCT
eurjchem-1748	139	4	schrödinger	schrödinger	NOUN
eurjchem-1748	139	5	’s	’s	PART
eurjchem-1748	139	6	proprietary	proprietary	ADJ
eurjchem-1748	139	7	glidescore	glidescore	NOUN
eurjchem-1748	139	8	multi	multi	ADJ
eurjchem-1748	139	9	-	-	ADJ
eurjchem-1748	139	10	ligand	ligand	ADJ
eurjchem-1748	139	11	scoring	scoring	NOUN
eurjchem-1748	139	12	function	function	NOUN
eurjchem-1748	139	13	is	be	AUX
eurjchem-1748	139	14	used	use	VERB
eurjchem-1748	139	15	to	to	PART
eurjchem-1748	139	16	score	score	VERB
eurjchem-1748	139	17	the	the	DET
eurjchem-1748	139	18	poses	pose	NOUN
eurjchem-1748	139	19	.	.	PUNCT
eurjchem-1748	140	1	emodel	emodel	NOUN
eurjchem-1748	140	2	which	which	PRON
eurjchem-1748	140	3	is	be	AUX
eurjchem-1748	140	4	used	use	VERB
eurjchem-1748	140	5	to	to	PART
eurjchem-1748	140	6	rank	rank	VERB
eurjchem-1748	140	7	the	the	DET
eurjchem-1748	140	8	poses	pose	NOUN
eurjchem-1748	140	9	,	,	PUNCT
eurjchem-1748	140	10	combines	combine	VERB
eurjchem-1748	140	11	glidescore	glidescore	NOUN
eurjchem-1748	140	12	,	,	PUNCT
eurjchem-1748	140	13	the	the	DET
eurjchem-1748	140	14	non	non	ADJ
eurjchem-1748	140	15	-	-	ADJ
eurjchem-1748	140	16	bonded	bonded	ADJ
eurjchem-1748	140	17	interaction	interaction	NOUN
eurjchem-1748	140	18	energy	energy	NOUN
eurjchem-1748	140	19	and	and	CCONJ
eurjchem-1748	140	20	for	for	ADP
eurjchem-1748	140	21	rigid	rigid	ADJ
eurjchem-1748	140	22	docking	docking	NOUN
eurjchem-1748	140	23	,	,	PUNCT
eurjchem-1748	140	24	the	the	DET
eurjchem-1748	140	25	excess	excess	ADJ
eurjchem-1748	140	26	internal	internal	ADJ
eurjchem-1748	140	27	energy	energy	NOUN
eurjchem-1748	140	28	of	of	ADP
eurjchem-1748	140	29	the	the	DET
eurjchem-1748	140	30	generated	generate	VERB
eurjchem-1748	140	31	ligand	ligand	NOUN
eurjchem-1748	140	32	conformation	conformation	NOUN
eurjchem-1748	140	33	.	.	PUNCT
eurjchem-1748	141	1	2.3	2.3	NUM
eurjchem-1748	141	2	.	.	PUNCT
eurjchem-1748	142	1	preparation	preparation	NOUN
eurjchem-1748	142	2	of	of	ADP
eurjchem-1748	142	3	protein	protein	NOUN
eurjchem-1748	142	4	structures	structure	VERB
eurjchem-1748	142	5	the	the	DET
eurjchem-1748	142	6	crystal	crystal	NOUN
eurjchem-1748	142	7	structure	structure	NOUN
eurjchem-1748	142	8	of	of	ADP
eurjchem-1748	142	9	tubulin	tubulin	NOUN
eurjchem-1748	142	10	(	(	PUNCT
eurjchem-1748	142	11	pdb	pdb	PROPN
eurjchem-1748	142	12	i	i	PROPN
eurjchem-1748	142	13	d	d	PROPN
eurjchem-1748	142	14	3wy1	3wy1	NUM
eurjchem-1748	142	15	)	)	PUNCT
eurjchem-1748	142	16	was	be	AUX
eurjchem-1748	142	17	considered	consider	VERB
eurjchem-1748	142	18	to	to	PART
eurjchem-1748	142	19	get	get	VERB
eurjchem-1748	142	20	insights	insight	NOUN
eurjchem-1748	142	21	into	into	ADP
eurjchem-1748	142	22	the	the	DET
eurjchem-1748	142	23	binding	bind	VERB
eurjchem-1748	142	24	modes	mode	NOUN
eurjchem-1748	142	25	of	of	ADP
eurjchem-1748	142	26	ligands	ligand	NOUN
eurjchem-1748	142	27	.	.	PUNCT
eurjchem-1748	143	1	the	the	DET
eurjchem-1748	143	2	protein	protein	NOUN
eurjchem-1748	143	3	x	x	NOUN
eurjchem-1748	143	4	-	-	NOUN
eurjchem-1748	143	5	ray	ray	NOUN
eurjchem-1748	143	6	structure	structure	NOUN
eurjchem-1748	143	7	was	be	AUX
eurjchem-1748	143	8	prepared	prepare	VERB
eurjchem-1748	143	9	using	use	VERB
eurjchem-1748	143	10	the	the	DET
eurjchem-1748	143	11	protein	protein	NOUN
eurjchem-1748	143	12	preparation	preparation	NOUN
eurjchem-1748	143	13	wizard	wizard	NOUN
eurjchem-1748	143	14	implemented	implement	VERB
eurjchem-1748	143	15	in	in	ADP
eurjchem-1748	143	16	maestro	maestro	NOUN
eurjchem-1748	143	17	11.4	11.4	NUM
eurjchem-1748	143	18	(	(	PUNCT
eurjchem-1748	143	19	schrödinger	schrödinger	PROPN
eurjchem-1748	143	20	,	,	PUNCT
eurjchem-1748	143	21	llc	llc	PROPN
eurjchem-1748	143	22	,	,	PUNCT
eurjchem-1748	143	23	new	new	PROPN
eurjchem-1748	143	24	york	york	PROPN
eurjchem-1748	143	25	,	,	PUNCT
eurjchem-1748	143	26	ny	ny	PROPN
eurjchem-1748	143	27	,	,	PUNCT
eurjchem-1748	143	28	2017	2017	NUM
eurjchem-1748	143	29	)	)	PUNCT
eurjchem-1748	143	30	with	with	ADP
eurjchem-1748	143	31	the	the	DET
eurjchem-1748	143	32	following	follow	VERB
eurjchem-1748	143	33	steps	step	NOUN
eurjchem-1748	143	34	(	(	PUNCT
eurjchem-1748	143	35	i	i	NOUN
eurjchem-1748	143	36	)	)	PUNCT
eurjchem-1748	143	37	the	the	DET
eurjchem-1748	143	38	missing	miss	VERB
eurjchem-1748	143	39	side	side	NOUN
eurjchem-1748	143	40	chains	chain	NOUN
eurjchem-1748	143	41	were	be	AUX
eurjchem-1748	143	42	added	add	VERB
eurjchem-1748	143	43	to	to	ADP
eurjchem-1748	143	44	the	the	DET
eurjchem-1748	143	45	crystal	crystal	NOUN
eurjchem-1748	143	46	structure	structure	NOUN
eurjchem-1748	143	47	by	by	ADP
eurjchem-1748	143	48	schrödinger	schrödinger	PROPN
eurjchem-1748	143	49	’s	’s	PART
eurjchem-1748	143	50	prime	prime	PROPN
eurjchem-1748	143	51	3.0	3.0	NUM
eurjchem-1748	143	52	.	.	PUNCT
eurjchem-1748	144	1	(	(	PUNCT
eurjchem-1748	144	2	ii	ii	NOUN
eurjchem-1748	144	3	)	)	PUNCT
eurjchem-1748	144	4	hydrogen	hydrogen	NOUN
eurjchem-1748	144	5	bond	bond	NOUN
eurjchem-1748	144	6	atoms	atom	NOUN
eurjchem-1748	144	7	were	be	AUX
eurjchem-1748	144	8	added	add	VERB
eurjchem-1748	144	9	and	and	CCONJ
eurjchem-1748	144	10	water	water	NOUN
eurjchem-1748	144	11	molecules	molecule	NOUN
eurjchem-1748	144	12	within	within	ADP
eurjchem-1748	144	13	5	5	NUM
eurjchem-1748	144	14	å	å	PROPN
eurjchem-1748	144	15	of	of	ADP
eurjchem-1748	144	16	the	the	DET
eurjchem-1748	144	17	cocrystallized	cocrystallize	VERB
eurjchem-1748	144	18	ligand	ligand	NOUN
eurjchem-1748	144	19	were	be	AUX
eurjchem-1748	144	20	removed	remove	VERB
eurjchem-1748	144	21	.	.	PUNCT
eurjchem-1748	145	1	(	(	PUNCT
eurjchem-1748	145	2	iii	iii	X
eurjchem-1748	145	3	)	)	PUNCT
eurjchem-1748	145	4	protonation	protonation	NOUN
eurjchem-1748	145	5	states	state	NOUN
eurjchem-1748	145	6	of	of	ADP
eurjchem-1748	145	7	entire	entire	ADJ
eurjchem-1748	145	8	systems	system	NOUN
eurjchem-1748	145	9	were	be	AUX
eurjchem-1748	145	10	adjusted	adjust	VERB
eurjchem-1748	145	11	to	to	ADP
eurjchem-1748	145	12	the	the	DET
eurjchem-1748	145	13	ph	ph	ADJ
eurjchem-1748	145	14	range	range	NOUN
eurjchem-1748	145	15	of	of	ADP
eurjchem-1748	145	16	7.0+/-4.0	7.0+/-4.0	NUM
eurjchem-1748	145	17	using	use	VERB
eurjchem-1748	145	18	epik	epik	PROPN
eurjchem-1748	145	19	.	.	PUNCT
eurjchem-1748	146	1	(	(	PUNCT
eurjchem-1748	146	2	iv	iv	X
eurjchem-1748	146	3	)	)	PUNCT
eurjchem-1748	146	4	hydrogen	hydrogen	NOUN
eurjchem-1748	146	5	bond	bond	NOUN
eurjchem-1748	146	6	networks	network	NOUN
eurjchem-1748	146	7	and	and	CCONJ
eurjchem-1748	146	8	flip	flip	ADJ
eurjchem-1748	146	9	orientations	orientation	NOUN
eurjchem-1748	146	10	/	/	SYM
eurjchem-1748	146	11	tautomeric	tautomeric	ADJ
eurjchem-1748	146	12	states	state	NOUN
eurjchem-1748	146	13	of	of	ADP
eurjchem-1748	146	14	gln	gln	PROPN
eurjchem-1748	146	15	,	,	PUNCT
eurjchem-1748	146	16	asn	asn	PROPN
eurjchem-1748	146	17	,	,	PUNCT
eurjchem-1748	146	18	and	and	CCONJ
eurjchem-1748	146	19	his	his	PRON
eurjchem-1748	146	20	residues	residue	NOUN
eurjchem-1748	146	21	were	be	AUX
eurjchem-1748	146	22	optimized	optimize	VERB
eurjchem-1748	146	23	.	.	PUNCT
eurjchem-1748	147	1	(	(	PUNCT
eurjchem-1748	147	2	v	v	NOUN
eurjchem-1748	147	3	)	)	PUNCT
eurjchem-1748	147	4	the	the	DET
eurjchem-1748	147	5	geometry	geometry	NOUN
eurjchem-1748	147	6	optimization	optimization	NOUN
eurjchem-1748	147	7	was	be	AUX
eurjchem-1748	147	8	performed	perform	VERB
eurjchem-1748	147	9	to	to	ADP
eurjchem-1748	147	10	a	a	DET
eurjchem-1748	147	11	maximum	maximum	ADJ
eurjchem-1748	147	12	root	root	NOUN
eurjchem-1748	147	13	mean	mean	ADJ
eurjchem-1748	147	14	square	square	ADJ
eurjchem-1748	147	15	deviation	deviation	NOUN
eurjchem-1748	147	16	(	(	PUNCT
eurjchem-1748	147	17	rmsd	rmsd	NOUN
eurjchem-1748	147	18	)	)	PUNCT
eurjchem-1748	147	19	of	of	ADP
eurjchem-1748	147	20	0.3	0.3	NUM
eurjchem-1748	147	21	å	å	NOUN
eurjchem-1748	147	22	with	with	ADP
eurjchem-1748	147	23	the	the	DET
eurjchem-1748	147	24	opls2005	opls2005	ADJ
eurjchem-1748	147	25	force	force	NOUN
eurjchem-1748	147	26	field	field	NOUN
eurjchem-1748	147	27	.	.	PUNCT
eurjchem-1748	148	1	2.4	2.4	NUM
eurjchem-1748	148	2	.	.	PUNCT
eurjchem-1748	149	1	receptor	receptor	NOUN
eurjchem-1748	149	2	grid	grid	NOUN
eurjchem-1748	149	3	generation	generation	NOUN
eurjchem-1748	149	4	and	and	CCONJ
eurjchem-1748	149	5	docking	dock	VERB
eurjchem-1748	149	6	grid	grid	NOUN
eurjchem-1748	149	7	was	be	AUX
eurjchem-1748	149	8	generated	generate	VERB
eurjchem-1748	149	9	using	use	VERB
eurjchem-1748	149	10	receptor	receptor	NOUN
eurjchem-1748	149	11	grid	grid	NOUN
eurjchem-1748	149	12	generation	generation	NOUN
eurjchem-1748	149	13	in	in	ADP
eurjchem-1748	149	14	glide	glide	NOUN
eurjchem-1748	149	15	program	program	NOUN
eurjchem-1748	149	16	.	.	PUNCT
eurjchem-1748	150	1	the	the	DET
eurjchem-1748	150	2	binding	bind	VERB
eurjchem-1748	150	3	region	region	NOUN
eurjchem-1748	150	4	was	be	AUX
eurjchem-1748	150	5	defined	define	VERB
eurjchem-1748	150	6	using	use	VERB
eurjchem-1748	150	7	a	a	DET
eurjchem-1748	150	8	co	co	NOUN
eurjchem-1748	150	9	-	-	NOUN
eurjchem-1748	150	10	crystal	crystal	ADJ
eurjchem-1748	150	11	ligand	ligand	NOUN
eurjchem-1748	150	12	.	.	PUNCT
eurjchem-1748	151	1	docking	dock	VERB
eurjchem-1748	151	2	studies	study	NOUN
eurjchem-1748	151	3	docking	docking	NOUN
eurjchem-1748	151	4	has	have	AUX
eurjchem-1748	151	5	performed	perform	VERB
eurjchem-1748	151	6	with	with	ADP
eurjchem-1748	151	7	the	the	DET
eurjchem-1748	151	8	solved	solve	VERB
eurjchem-1748	151	9	3d	3d	NOUN
eurjchem-1748	151	10	-	-	PUNCT
eurjchem-1748	151	11	structure	structure	NOUN
eurjchem-1748	151	12	of	of	ADP
eurjchem-1748	151	13	α	α	NOUN
eurjchem-1748	151	14	-	-	NOUN
eurjchem-1748	151	15	glucosidase	glucosidase	PROPN
eurjchem-1748	151	16	(	(	PUNCT
eurjchem-1748	151	17	pdb	pdb	NOUN
eurjchem-1748	151	18	i	i	NOUN
eurjchem-1748	151	19	d	d	PROPN
eurjchem-1748	151	20	3w37	3w37	NUM
eurjchem-1748	151	21	)	)	PUNCT
eurjchem-1748	151	22	,	,	PUNCT
eurjchem-1748	151	23	using	use	VERB
eurjchem-1748	151	24	glide	glide	NOUN
eurjchem-1748	151	25	module	module	NOUN
eurjchem-1748	151	26	in	in	ADP
eurjchem-1748	151	27	schrodinger	schrodinger	PROPN
eurjchem-1748	151	28	.	.	PUNCT
eurjchem-1748	152	1	the	the	DET
eurjchem-1748	152	2	authenticity	authenticity	NOUN
eurjchem-1748	152	3	of	of	ADP
eurjchem-1748	152	4	this	this	DET
eurjchem-1748	152	5	docking	docking	NOUN
eurjchem-1748	152	6	method	method	NOUN
eurjchem-1748	152	7	to	to	PART
eurjchem-1748	152	8	predict	predict	VERB
eurjchem-1748	152	9	the	the	DET
eurjchem-1748	152	10	bioactive	bioactive	ADJ
eurjchem-1748	152	11	conformation	conformation	NOUN
eurjchem-1748	152	12	was	be	AUX
eurjchem-1748	152	13	validated	validate	VERB
eurjchem-1748	152	14	using	use	VERB
eurjchem-1748	152	15	the	the	DET
eurjchem-1748	152	16	x	x	ADJ
eurjchem-1748	152	17	-	-	NOUN
eurjchem-1748	152	18	ray	ray	NOUN
eurjchem-1748	152	19	structure	structure	NOUN
eurjchem-1748	152	20	of	of	ADP
eurjchem-1748	152	21	acarbose	acarbose	NOUN
eurjchem-1748	152	22	in	in	ADP
eurjchem-1748	152	23	complex	complex	NOUN
eurjchem-1748	152	24	with	with	ADP
eurjchem-1748	152	25	a	a	DET
eurjchem-1748	152	26	cocrystal	cocrystal	ADJ
eurjchem-1748	152	27	acarbose	acarbose	NOUN
eurjchem-1748	152	28	.	.	PUNCT
eurjchem-1748	153	1	co	co	VERB
eurjchem-1748	153	2	-	-	NOUN
eurjchem-1748	153	3	crystal	crystal	ADJ
eurjchem-1748	153	4	acarbose	acarbose	NOUN
eurjchem-1748	153	5	was	be	AUX
eurjchem-1748	153	6	redocked	redocke	VERB
eurjchem-1748	153	7	into	into	ADP
eurjchem-1748	153	8	the	the	DET
eurjchem-1748	153	9	active	active	ADJ
eurjchem-1748	153	10	site	site	NOUN
eurjchem-1748	153	11	of	of	ADP
eurjchem-1748	153	12	3wy1	3wy1	NUM
eurjchem-1748	153	13	and	and	CCONJ
eurjchem-1748	153	14	the	the	DET
eurjchem-1748	153	15	best	well	ADV
eurjchem-1748	153	16	predicted	predict	VERB
eurjchem-1748	153	17	bound	bind	VERB
eurjchem-1748	153	18	conformation	conformation	NOUN
eurjchem-1748	153	19	having	have	VERB
eurjchem-1748	153	20	lowest	low	ADJ
eurjchem-1748	153	21	docking	docking	NOUN
eurjchem-1748	153	22	energy	energy	NOUN
eurjchem-1748	153	23	was	be	AUX
eurjchem-1748	153	24	selected	select	VERB
eurjchem-1748	153	25	.	.	PUNCT
eurjchem-1748	154	1	glide	glide	PROPN
eurjchem-1748	154	2	uses	use	VERB
eurjchem-1748	154	3	an	an	DET
eurjchem-1748	154	4	explicit	explicit	ADJ
eurjchem-1748	154	5	water	water	NOUN
eurjchem-1748	154	6	model	model	NOUN
eurjchem-1748	154	7	for	for	ADP
eurjchem-1748	154	8	modelling	model	VERB
eurjchem-1748	154	9	salvation	salvation	NOUN
eurjchem-1748	154	10	effects	effect	NOUN
eurjchem-1748	154	11	[	[	X
eurjchem-1748	154	12	30,31	30,31	NUM
eurjchem-1748	154	13	]	]	PUNCT
eurjchem-1748	154	14	.	.	PUNCT
eurjchem-1748	155	1	the	the	DET
eurjchem-1748	155	2	demonstrated	demonstrate	VERB
eurjchem-1748	155	3	research	research	NOUN
eurjchem-1748	155	4	output	output	NOUN
eurjchem-1748	155	5	and	and	CCONJ
eurjchem-1748	155	6	results	result	NOUN
eurjchem-1748	155	7	are	be	AUX
eurjchem-1748	155	8	the	the	DET
eurjchem-1748	155	9	structural	structural	ADJ
eurjchem-1748	155	10	model	model	NOUN
eurjchem-1748	155	11	exploration	exploration	NOUN
eurjchem-1748	155	12	and	and	CCONJ
eurjchem-1748	155	13	involved	involved	ADJ
eurjchem-1748	155	14	methodology	methodology	NOUN
eurjchem-1748	155	15	is	be	AUX
eurjchem-1748	155	16	very	very	ADV
eurjchem-1748	155	17	effective	effective	ADJ
eurjchem-1748	155	18	,	,	PUNCT
eurjchem-1748	155	19	which	which	PRON
eurjchem-1748	155	20	was	be	AUX
eurjchem-1748	155	21	analyzed	analyze	VERB
eurjchem-1748	155	22	in	in	ADP
eurjchem-1748	155	23	few	few	ADJ
eurjchem-1748	155	24	of	of	ADP
eurjchem-1748	155	25	research	research	NOUN
eurjchem-1748	155	26	papers	paper	NOUN
eurjchem-1748	155	27	also	also	ADV
eurjchem-1748	155	28	[	[	X
eurjchem-1748	155	29	21,25,32	21,25,32	NUM
eurjchem-1748	155	30	]	]	X
eurjchem-1748	155	31	.	.	PUNCT
eurjchem-1748	156	1	in	in	ADP
eurjchem-1748	156	2	this	this	DET
eurjchem-1748	156	3	methodology	methodology	NOUN
eurjchem-1748	156	4	,	,	PUNCT
eurjchem-1748	156	5	we	we	PRON
eurjchem-1748	156	6	taken	take	VERB
eurjchem-1748	156	7	g	g	NOUN
eurjchem-1748	156	8	-	-	PUNCT
eurjchem-1748	156	9	score	score	NOUN
eurjchem-1748	156	10	,	,	PUNCT
eurjchem-1748	156	11	which	which	PRON
eurjchem-1748	156	12	is	be	AUX
eurjchem-1748	156	13	a	a	DET
eurjchem-1748	156	14	modified	modified	ADJ
eurjchem-1748	156	15	and	and	CCONJ
eurjchem-1748	156	16	extended	extended	ADJ
eurjchem-1748	156	17	empirical	empirical	ADJ
eurjchem-1748	156	18	scoring	scoring	NOUN
eurjchem-1748	156	19	function	function	NOUN
eurjchem-1748	156	20	based	base	VERB
eurjchem-1748	156	21	on	on	ADP
eurjchem-1748	156	22	chem	chem	NOUN
eurjchem-1748	156	23	-	-	PUNCT
eurjchem-1748	156	24	score	score	NOUN
eurjchem-1748	156	25	the	the	DET
eurjchem-1748	156	26	docking	docking	NOUN
eurjchem-1748	156	27	method	method	NOUN
eurjchem-1748	156	28	that	that	PRON
eurjchem-1748	156	29	is	be	AUX
eurjchem-1748	156	30	xp	xp	PROPN
eurjchem-1748	156	31	descriptors	descriptor	NOUN
eurjchem-1748	156	32	been	be	AUX
eurjchem-1748	156	33	used	use	VERB
eurjchem-1748	156	34	to	to	PART
eurjchem-1748	156	35	score	score	VERB
eurjchem-1748	156	36	[	[	X
eurjchem-1748	156	37	33,34	33,34	NOUN
eurjchem-1748	156	38	]	]	X
eurjchem-1748	156	39	(	(	PUNCT
eurjchem-1748	156	40	g	g	NOUN
eurjchem-1748	156	41	-	-	PUNCT
eurjchem-1748	156	42	score	score	NOUN
eurjchem-1748	156	43	)	)	PUNCT
eurjchem-1748	156	44	for	for	ADP
eurjchem-1748	156	45	ligand	ligand	NOUN
eurjchem-1748	156	46	includes	include	VERB
eurjchem-1748	156	47	drug	drug	NOUN
eurjchem-1748	156	48	like	like	ADP
eurjchem-1748	156	49	properties	property	NOUN
eurjchem-1748	156	50	such	such	ADJ
eurjchem-1748	156	51	as	as	ADP
eurjchem-1748	156	52	lipo	lipo	NOUN
eurjchem-1748	156	53	-	-	PUNCT
eurjchem-1748	156	54	evdw	evdw	NOUN
eurjchem-1748	156	55	,	,	PUNCT
eurjchem-1748	156	56	h	h	NOUN
eurjchem-1748	156	57	-	-	PUNCT
eurjchem-1748	156	58	bond	bond	NOUN
eurjchem-1748	156	59	,	,	PUNCT
eurjchem-1748	156	60	and	and	CCONJ
eurjchem-1748	156	61	rotpenal	rotpenal	NOUN
eurjchem-1748	156	62	.	.	PUNCT
eurjchem-1748	157	1	lipoevdw	lipoevdw	PROPN
eurjchem-1748	157	2	is	be	AUX
eurjchem-1748	157	3	the	the	DET
eurjchem-1748	157	4	chem	chem	NOUN
eurjchem-1748	157	5	-	-	PUNCT
eurjchem-1748	157	6	score	score	NOUN
eurjchem-1748	157	7	lipophilic	lipophilic	ADJ
eurjchem-1748	157	8	pair	pair	NOUN
eurjchem-1748	157	9	term	term	NOUN
eurjchem-1748	157	10	and	and	CCONJ
eurjchem-1748	157	11	fraction	fraction	NOUN
eurjchem-1748	157	12	of	of	ADP
eurjchem-1748	157	13	the	the	DET
eurjchem-1748	157	14	total	total	ADJ
eurjchem-1748	157	15	receptor	receptor	NOUN
eurjchem-1748	157	16	-	-	PUNCT
eurjchem-1748	157	17	ligand	ligand	NOUN
eurjchem-1748	157	18	vdw	vdw	NOUN
eurjchem-1748	157	19	’s	’s	PART
eurjchem-1748	157	20	energy	energy	NOUN
eurjchem-1748	157	21	.	.	PUNCT
eurjchem-1748	158	1	h	h	NOUN
eurjchem-1748	158	2	-	-	PUNCT
eurjchem-1748	158	3	bond	bond	NOUN
eurjchem-1748	158	4	is	be	AUX
eurjchem-1748	158	5	the	the	DET
eurjchem-1748	158	6	chemscore	chemscore	ADJ
eurjchem-1748	158	7	h	h	NOUN
eurjchem-1748	158	8	-	-	PUNCT
eurjchem-1748	158	9	bonding	bond	VERB
eurjchem-1748	158	10	pair	pair	NOUN
eurjchem-1748	158	11	term	term	NOUN
eurjchem-1748	158	12	.	.	PUNCT
eurjchem-1748	159	1	non	non	ADJ
eurjchem-1748	159	2	-	-	ADJ
eurjchem-1748	159	3	h	h	NOUN
eurjchem-1748	159	4	-	-	PUNCT
eurjchem-1748	159	5	bonding	bond	VERB
eurjchem-1748	159	6	polar	polar	ADJ
eurjchem-1748	159	7	/	/	SYM
eurjchem-1748	159	8	hydrophobic	hydrophobic	NOUN
eurjchem-1748	159	9	interactions	interaction	NOUN
eurjchem-1748	159	10	following	follow	VERB
eurjchem-1748	159	11	generation	generation	NOUN
eurjchem-1748	159	12	of	of	ADP
eurjchem-1748	159	13	hydrophobichydrophilic	hydrophobichydrophilic	ADJ
eurjchem-1748	159	14	surfaces	surface	NOUN
eurjchem-1748	159	15	[	[	X
eurjchem-1748	159	16	21,32,35	21,32,35	NUM
eurjchem-1748	159	17	]	]	PUNCT
eurjchem-1748	159	18	.	.	PUNCT
eurjchem-1748	160	1	2.5	2.5	NUM
eurjchem-1748	160	2	.	.	PUNCT
eurjchem-1748	160	3	biology	biology	NOUN
eurjchem-1748	160	4	assays	assay	VERB
eurjchem-1748	160	5	α	α	NOUN
eurjchem-1748	160	6	-	-	PUNCT
eurjchem-1748	160	7	glucosidase	glucosidase	ADJ
eurjchem-1748	160	8	inhibitory	inhibitory	NOUN
eurjchem-1748	160	9	assay	assay	VERB
eurjchem-1748	160	10	:	:	PUNCT
eurjchem-1748	160	11	the	the	DET
eurjchem-1748	160	12	inhibitory	inhibitory	ADJ
eurjchem-1748	160	13	effect	effect	NOUN
eurjchem-1748	160	14	of	of	ADP
eurjchem-1748	160	15	the	the	DET
eurjchem-1748	160	16	synthesized	synthesize	VERB
eurjchem-1748	160	17	compounds	compound	NOUN
eurjchem-1748	160	18	on	on	ADP
eurjchem-1748	160	19	α	α	NOUN
eurjchem-1748	160	20	-	-	PUNCT
eurjchem-1748	160	21	glucosidase	glucosidase	ADJ
eurjchem-1748	160	22	inhibitory	inhibitory	ADJ
eurjchem-1748	160	23	activity	activity	NOUN
eurjchem-1748	160	24	was	be	AUX
eurjchem-1748	160	25	determined	determine	VERB
eurjchem-1748	160	26	in	in	ADP
eurjchem-1748	160	27	96	96	NUM
eurjchem-1748	160	28	-	-	PUNCT
eurjchem-1748	160	29	well	well	NOUN
eurjchem-1748	160	30	plates	plate	NOUN
eurjchem-1748	160	31	employing	employ	VERB
eurjchem-1748	160	32	the	the	DET
eurjchem-1748	160	33	substrate	substrate	NOUN
eurjchem-1748	160	34	pnpg	pnpg	NOUN
eurjchem-1748	160	35	and	and	CCONJ
eurjchem-1748	160	36	4	4	NUM
eurjchem-1748	160	37	-	-	PUNCT
eurjchem-1748	160	38	nitrophenyl	nitrophenyl	ADJ
eurjchem-1748	160	39	α	α	PROPN
eurjchem-1748	160	40	-	-	PUNCT
eurjchem-1748	160	41	d	d	NOUN
eurjchem-1748	160	42	-	-	PUNCT
eurjchem-1748	160	43	glucopyranoside	glucopyranoside	NOUN
eurjchem-1748	160	44	according	accord	VERB
eurjchem-1748	160	45	to	to	ADP
eurjchem-1748	160	46	the	the	DET
eurjchem-1748	160	47	procedure	procedure	NOUN
eurjchem-1748	160	48	previously	previously	ADV
eurjchem-1748	160	49	reported	report	VERB
eurjchem-1748	160	50	by	by	ADP
eurjchem-1748	160	51	ferreres	ferrere	NOUN
eurjchem-1748	160	52	et	et	PROPN
eurjchem-1748	160	53	al	al	PROPN
eurjchem-1748	160	54	.	.	PUNCT
eurjchem-1748	161	1	[	[	X
eurjchem-1748	161	2	2	2	NUM
eurjchem-1748	161	3	]	]	PUNCT
eurjchem-1748	161	4	.	.	PUNCT
eurjchem-1748	162	1	prior	prior	ADV
eurjchem-1748	162	2	to	to	ADP
eurjchem-1748	162	3	use	use	NOUN
eurjchem-1748	162	4	,	,	PUNCT
eurjchem-1748	162	5	all	all	DET
eurjchem-1748	162	6	test	test	NOUN
eurjchem-1748	162	7	compounds	compound	NOUN
eurjchem-1748	162	8	were	be	AUX
eurjchem-1748	162	9	solubilised	solubilise	VERB
eurjchem-1748	162	10	in	in	ADP
eurjchem-1748	162	11	solvent	solvent	NOUN
eurjchem-1748	162	12	,	,	PUNCT
eurjchem-1748	162	13	dimethylsulfoxide	dimethylsulfoxide	ADV
eurjchem-1748	162	14	(	(	PUNCT
eurjchem-1748	162	15	dmso	dmso	NOUN
eurjchem-1748	162	16	)	)	PUNCT
eurjchem-1748	162	17	.	.	PUNCT
eurjchem-1748	163	1	briefly	briefly	ADV
eurjchem-1748	163	2	,	,	PUNCT
eurjchem-1748	163	3	each	each	PRON
eurjchem-1748	163	4	well	well	ADV
eurjchem-1748	163	5	in	in	ADP
eurjchem-1748	163	6	96	96	NUM
eurjchem-1748	163	7	-	-	PUNCT
eurjchem-1748	163	8	well	well	NOUN
eurjchem-1748	163	9	plates	plate	NOUN
eurjchem-1748	163	10	contained	contain	VERB
eurjchem-1748	163	11	100	100	NUM
eurjchem-1748	163	12	µl	µl	NOUN
eurjchem-1748	163	13	of	of	ADP
eurjchem-1748	163	14	2	2	NUM
eurjchem-1748	163	15	mm	mm	NOUN
eurjchem-1748	163	16	4	4	NUM
eurjchem-1748	163	17	-	-	PUNCT
eurjchem-1748	163	18	nitrophenyl	nitrophenyl	ADJ
eurjchem-1748	163	19	α	α	PROPN
eurjchem-1748	163	20	-	-	PUNCT
eurjchem-1748	163	21	d	d	NOUN
eurjchem-1748	163	22	-	-	PUNCT
eurjchem-1748	163	23	glucopyranoside	glucopyranoside	NOUN
eurjchem-1748	163	24	(	(	PUNCT
eurjchem-1748	163	25	pnp	pnp	NOUN
eurjchem-1748	163	26	-	-	PUNCT
eurjchem-1748	163	27	g	g	NOUN
eurjchem-1748	163	28	)	)	PUNCT
eurjchem-1748	163	29	in	in	ADP
eurjchem-1748	163	30	10	10	NUM
eurjchem-1748	163	31	mm	mm	NOUN
eurjchem-1748	163	32	potassium	potassium	NOUN
eurjchem-1748	163	33	phosphate	phosphate	NOUN
eurjchem-1748	163	34	buffer	buffer	NOUN
eurjchem-1748	163	35	(	(	PUNCT
eurjchem-1748	163	36	ph	ph	NOUN
eurjchem-1748	163	37	=	=	NOUN
eurjchem-1748	163	38	7.2	7.2	NUM
eurjchem-1748	163	39	)	)	PUNCT
eurjchem-1748	163	40	and	and	CCONJ
eurjchem-1748	163	41	different	different	ADJ
eurjchem-1748	163	42	test	test	NOUN
eurjchem-1748	163	43	concentrations	concentration	NOUN
eurjchem-1748	163	44	(	(	PUNCT
eurjchem-1748	163	45	20	20	NUM
eurjchem-1748	163	46	-	-	SYM
eurjchem-1748	163	47	100	100	NUM
eurjchem-1748	163	48	µg	µg	NOUN
eurjchem-1748	163	49	/	/	SYM
eurjchem-1748	163	50	ml	ml	NOUN
eurjchem-1748	163	51	)	)	PUNCT
eurjchem-1748	163	52	.	.	PUNCT
eurjchem-1748	164	1	the	the	DET
eurjchem-1748	164	2	reaction	reaction	NOUN
eurjchem-1748	164	3	was	be	AUX
eurjchem-1748	164	4	initiated	initiate	VERB
eurjchem-1748	164	5	by	by	ADP
eurjchem-1748	164	6	the	the	DET
eurjchem-1748	164	7	addition	addition	NOUN
eurjchem-1748	164	8	of	of	ADP
eurjchem-1748	164	9	5	5	NUM
eurjchem-1748	164	10	µl	µl	NOUN
eurjchem-1748	164	11	of	of	ADP
eurjchem-1748	164	12	the	the	DET
eurjchem-1748	164	13	enzyme	enzyme	NOUN
eurjchem-1748	164	14	solution	solution	NOUN
eurjchem-1748	164	15	(	(	PUNCT
eurjchem-1748	164	16	0.1	0.1	NUM
eurjchem-1748	164	17	iu	iu	ADV
eurjchem-1748	164	18	per	per	ADV
eurjchem-1748	164	19	well	well	ADV
eurjchem-1748	164	20	)	)	PUNCT
eurjchem-1748	164	21	,	,	PUNCT
eurjchem-1748	164	22	α	α	X
eurjchem-1748	164	23	-	-	NOUN
eurjchem-1748	164	24	glucosidase	glucosidase	PROPN
eurjchem-1748	164	25	(	(	PUNCT
eurjchem-1748	164	26	obtained	obtain	VERB
eurjchem-1748	164	27	from	from	ADP
eurjchem-1748	164	28	baker	baker	PROPN
eurjchem-1748	164	29	’s	’s	PART
eurjchem-1748	164	30	yeast	yeast	NOUN
eurjchem-1748	164	31	purchased	purchase	VERB
eurjchem-1748	164	32	from	from	ADP
eurjchem-1748	164	33	sigma	sigma	PROPN
eurjchem-1748	164	34	aldrich	aldrich	PROPN
eurjchem-1748	164	35	,	,	PUNCT
eurjchem-1748	164	36	bangaluru	bangaluru	VERB
eurjchem-1748	164	37	)	)	PUNCT
eurjchem-1748	164	38	.	.	PUNCT
eurjchem-1748	165	1	the	the	DET
eurjchem-1748	165	2	plates	plate	NOUN
eurjchem-1748	165	3	were	be	AUX
eurjchem-1748	165	4	incubated	incubate	VERB
eurjchem-1748	165	5	at	at	ADP
eurjchem-1748	165	6	37	37	NUM
eurjchem-1748	165	7	°	°	NOUN
eurjchem-1748	165	8	c	c	NOUN
eurjchem-1748	165	9	for	for	ADP
eurjchem-1748	165	10	10	10	NUM
eurjchem-1748	165	11	min	min	NOUN
eurjchem-1748	165	12	.	.	PUNCT
eurjchem-1748	166	1	the	the	DET
eurjchem-1748	166	2	absorbance	absorbance	NOUN
eurjchem-1748	166	3	was	be	AUX
eurjchem-1748	166	4	measured	measure	VERB
eurjchem-1748	166	5	spectrophotometrically	spectrophotometrically	ADV
eurjchem-1748	166	6	at	at	ADP
eurjchem-1748	166	7	430	430	NUM
eurjchem-1748	166	8	nm	nm	NOUN
eurjchem-1748	166	9	(	(	PUNCT
eurjchem-1748	166	10	spectra	spectra	PROPN
eurjchem-1748	166	11	max	max	PROPN
eurjchem-1748	166	12	m5e	m5e	PROPN
eurjchem-1748	166	13	micro	micro	PROPN
eurjchem-1748	166	14	plate	plate	NOUN
eurjchem-1748	166	15	reader	reader	NOUN
eurjchem-1748	166	16	)	)	PUNCT
eurjchem-1748	166	17	.	.	PUNCT
eurjchem-1748	167	1	the	the	DET
eurjchem-1748	167	2	increase	increase	NOUN
eurjchem-1748	167	3	in	in	ADP
eurjchem-1748	167	4	absorbance	absorbance	NOUN
eurjchem-1748	167	5	(	(	PUNCT
eurjchem-1748	167	6	δa	δa	NOUN
eurjchem-1748	167	7	)	)	PUNCT
eurjchem-1748	167	8	was	be	AUX
eurjchem-1748	167	9	compared	compare	VERB
eurjchem-1748	167	10	with	with	ADP
eurjchem-1748	167	11	that	that	PRON
eurjchem-1748	167	12	of	of	ADP
eurjchem-1748	167	13	the	the	DET
eurjchem-1748	167	14	control	control	NOUN
eurjchem-1748	167	15	(	(	PUNCT
eurjchem-1748	167	16	buffer	buffer	NOUN
eurjchem-1748	167	17	instead	instead	ADV
eurjchem-1748	167	18	of	of	ADP
eurjchem-1748	167	19	test	test	NOUN
eurjchem-1748	167	20	compound	compound	NOUN
eurjchem-1748	167	21	)	)	PUNCT
eurjchem-1748	167	22	to	to	PART
eurjchem-1748	167	23	compute	compute	VERB
eurjchem-1748	167	24	the	the	DET
eurjchem-1748	167	25	inhibitory	inhibitory	ADJ
eurjchem-1748	167	26	concentrations	concentration	NOUN
eurjchem-1748	167	27	(	(	PUNCT
eurjchem-1748	167	28	ic50	ic50	PROPN
eurjchem-1748	167	29	)	)	PUNCT
eurjchem-1748	167	30	which	which	PRON
eurjchem-1748	167	31	was	be	AUX
eurjchem-1748	167	32	determined	determine	VERB
eurjchem-1748	167	33	from	from	ADP
eurjchem-1748	167	34	three	three	NUM
eurjchem-1748	167	35	independent	independent	ADJ
eurjchem-1748	167	36	assays	assay	NOUN
eurjchem-1748	167	37	.	.	PUNCT
eurjchem-1748	168	1	acarbose	acarbose	NOUN
eurjchem-1748	168	2	,	,	PUNCT
eurjchem-1748	168	3	an	an	DET
eurjchem-1748	168	4	illustrious	illustrious	ADJ
eurjchem-1748	168	5	inhibitor	inhibitor	NOUN
eurjchem-1748	168	6	of	of	ADP
eurjchem-1748	168	7	α	α	NOUN
eurjchem-1748	168	8	-	-	NOUN
eurjchem-1748	168	9	glucosidase	glucosidase	PROPN
eurjchem-1748	168	10	was	be	AUX
eurjchem-1748	168	11	employed	employ	VERB
eurjchem-1748	168	12	as	as	ADP
eurjchem-1748	168	13	positive	positive	ADJ
eurjchem-1748	168	14	control	control	NOUN
eurjchem-1748	168	15	.	.	PUNCT
eurjchem-1748	169	1	inhibition	inhibition	NOUN
eurjchem-1748	169	2	(	(	PUNCT
eurjchem-1748	169	3	%	%	INTJ
eurjchem-1748	169	4	)	)	PUNCT
eurjchem-1748	169	5	=	=	SYM
eurjchem-1748	169	6	(	(	PUNCT
eurjchem-1748	169	7	δacontrol	δacontrol	NOUN
eurjchem-1748	169	8	–	–	PUNCT
eurjchem-1748	169	9	δasample	δasample	NOUN
eurjchem-1748	169	10	/	/	SYM
eurjchem-1748	169	11	δacontrol	δacontrol	NOUN
eurjchem-1748	169	12	)	)	PUNCT
eurjchem-1748	169	13	×	×	NOUN
eurjchem-1748	169	14	100	100	NUM
eurjchem-1748	169	15	(	(	PUNCT
eurjchem-1748	169	16	1	1	NUM
eurjchem-1748	169	17	)	)	PUNCT
eurjchem-1748	169	18	the	the	DET
eurjchem-1748	169	19	concentration	concentration	NOUN
eurjchem-1748	169	20	of	of	ADP
eurjchem-1748	169	21	compound	compound	NOUN
eurjchem-1748	169	22	required	require	VERB
eurjchem-1748	169	23	to	to	PART
eurjchem-1748	169	24	obtain	obtain	VERB
eurjchem-1748	169	25	50	50	NUM
eurjchem-1748	169	26	%	%	NOUN
eurjchem-1748	169	27	inhibition	inhibition	NOUN
eurjchem-1748	169	28	of	of	ADP
eurjchem-1748	169	29	α	α	NOUN
eurjchem-1748	169	30	-	-	ADJ
eurjchem-1748	169	31	glucosidase	glucosidase	ADJ
eurjchem-1748	169	32	activity	activity	NOUN
eurjchem-1748	169	33	under	under	ADP
eurjchem-1748	169	34	the	the	DET
eurjchem-1748	169	35	assay	assay	NOUN
eurjchem-1748	169	36	conditions	condition	NOUN
eurjchem-1748	169	37	was	be	AUX
eurjchem-1748	169	38	defined	define	VERB
eurjchem-1748	169	39	as	as	ADP
eurjchem-1748	169	40	the	the	DET
eurjchem-1748	169	41	ic50	ic50	PROPN
eurjchem-1748	169	42	value	value	NOUN
eurjchem-1748	169	43	.	.	PUNCT
eurjchem-1748	170	1	2.6	2.6	NUM
eurjchem-1748	170	2	.	.	PUNCT
eurjchem-1748	170	3	in	in	ADP
eurjchem-1748	170	4	-	-	PUNCT
eurjchem-1748	170	5	vitro	vitro	X
eurjchem-1748	170	6	studies	study	NOUN
eurjchem-1748	170	7	grouping	group	VERB
eurjchem-1748	170	8	and	and	CCONJ
eurjchem-1748	170	9	preparation	preparation	NOUN
eurjchem-1748	170	10	of	of	ADP
eurjchem-1748	170	11	animals	animal	NOUN
eurjchem-1748	170	12	:	:	PUNCT
eurjchem-1748	170	13	rats	rat	NOUN
eurjchem-1748	170	14	were	be	AUX
eurjchem-1748	170	15	randomly	randomly	ADV
eurjchem-1748	170	16	divided	divide	VERB
eurjchem-1748	170	17	into	into	ADP
eurjchem-1748	170	18	8	8	NUM
eurjchem-1748	170	19	groups	group	NOUN
eurjchem-1748	170	20	each	each	PRON
eurjchem-1748	170	21	containing	contain	VERB
eurjchem-1748	170	22	10	10	NUM
eurjchem-1748	170	23	animals	animal	NOUN
eurjchem-1748	170	24	;	;	PUNCT
eurjchem-1748	170	25	control	control	NOUN
eurjchem-1748	170	26	group	group	NOUN
eurjchem-1748	170	27	,	,	PUNCT
eurjchem-1748	170	28	negative	negative	ADJ
eurjchem-1748	170	29	control	control	NOUN
eurjchem-1748	170	30	group	group	NOUN
eurjchem-1748	170	31	(	(	PUNCT
eurjchem-1748	170	32	stz	stz	NOUN
eurjchem-1748	170	33	)	)	PUNCT
eurjchem-1748	170	34	,	,	PUNCT
eurjchem-1748	170	35	a	a	DET
eurjchem-1748	170	36	group	group	NOUN
eurjchem-1748	170	37	,	,	PUNCT
eurjchem-1748	170	38	b	b	PROPN
eurjchem-1748	170	39	group	group	NOUN
eurjchem-1748	170	40	,	,	PUNCT
eurjchem-1748	170	41	c	c	PROPN
eurjchem-1748	170	42	group	group	NOUN
eurjchem-1748	170	43	,	,	PUNCT
eurjchem-1748	170	44	d	d	PROPN
eurjchem-1748	170	45	group	group	NOUN
eurjchem-1748	170	46	,	,	PUNCT
eurjchem-1748	170	47	e	e	PROPN
eurjchem-1748	170	48	group	group	NOUN
eurjchem-1748	170	49	,	,	PUNCT
eurjchem-1748	170	50	positive	positive	ADJ
eurjchem-1748	170	51	control	control	NOUN
eurjchem-1748	170	52	group	group	NOUN
eurjchem-1748	170	53	(	(	PUNCT
eurjchem-1748	170	54	pio	pio	PROPN
eurjchem-1748	170	55	)	)	PUNCT
eurjchem-1748	170	56	.	.	PUNCT
eurjchem-1748	171	1	control	control	PROPN
eurjchem-1748	171	2	group	group	PROPN
eurjchem-1748	171	3	was	be	AUX
eurjchem-1748	171	4	fed	feed	VERB
eurjchem-1748	171	5	with	with	ADP
eurjchem-1748	171	6	standard	standard	ADJ
eurjchem-1748	171	7	chow	chow	PROPN
eurjchem-1748	171	8	(	(	PUNCT
eurjchem-1748	171	9	calorific	calorific	ADJ
eurjchem-1748	171	10	value	value	NOUN
eurjchem-1748	171	11	,	,	PUNCT
eurjchem-1748	171	12	20	20	NUM
eurjchem-1748	171	13	-	-	SYM
eurjchem-1748	171	14	22	22	NUM
eurjchem-1748	171	15	kj	kj	PROPN
eurjchem-1748	171	16	/	/	SYM
eurjchem-1748	171	17	kg	kg	PROPN
eurjchem-1748	171	18	)	)	PUNCT
eurjchem-1748	171	19	and	and	CCONJ
eurjchem-1748	171	20	all	all	DET
eurjchem-1748	171	21	the	the	DET
eurjchem-1748	171	22	other	other	ADJ
eurjchem-1748	171	23	groups	group	NOUN
eurjchem-1748	171	24	were	be	AUX
eurjchem-1748	171	25	fed	feed	VERB
eurjchem-1748	171	26	with	with	ADP
eurjchem-1748	171	27	high	high	ADJ
eurjchem-1748	171	28	fat	fat	ADJ
eurjchem-1748	171	29	diet	diet	NOUN
eurjchem-1748	171	30	obtained	obtain	VERB
eurjchem-1748	171	31	from	from	ADP
eurjchem-1748	171	32	rayan	rayan	PROPN
eurjchem-1748	171	33	’s	’s	PART
eurjchem-1748	171	34	biotech	biotech	PROPN
eurjchem-1748	171	35	(	(	PUNCT
eurjchem-1748	171	36	calorific	calorific	ADJ
eurjchem-1748	171	37	value	value	NOUN
eurjchem-1748	171	38	,	,	PUNCT
eurjchem-1748	171	39	43	43	NUM
eurjchem-1748	171	40	-	-	SYM
eurjchem-1748	171	41	45	45	NUM
eurjchem-1748	171	42	kj	kj	PROPN
eurjchem-1748	171	43	/	/	SYM
eurjchem-1748	171	44	kg	kg	PROPN
eurjchem-1748	171	45	)	)	PUNCT
eurjchem-1748	171	46	for	for	ADP
eurjchem-1748	171	47	4	4	NUM
eurjchem-1748	171	48	weeks	week	NOUN
eurjchem-1748	171	49	.	.	PUNCT
eurjchem-1748	172	1	stz	stz	VERB
eurjchem-1748	172	2	45	45	NUM
eurjchem-1748	172	3	mg	mg	PROPN
eurjchem-1748	172	4	/	/	SYM
eurjchem-1748	172	5	kg	kg	PROPN
eurjchem-1748	172	6	(	(	PUNCT
eurjchem-1748	172	7	freshly	freshly	ADV
eurjchem-1748	172	8	prepared	prepare	VERB
eurjchem-1748	172	9	acetate	acetate	NOUN
eurjchem-1748	172	10	buffer	buffer	NOUN
eurjchem-1748	172	11	0.1	0.1	NUM
eurjchem-1748	172	12	m	m	NOUN
eurjchem-1748	172	13	,	,	PUNCT
eurjchem-1748	172	14	ph	ph	NOUN
eurjchem-1748	172	15	=	=	SYM
eurjchem-1748	172	16	4.5	4.5	NUM
eurjchem-1748	172	17	)	)	PUNCT
eurjchem-1748	172	18	was	be	AUX
eurjchem-1748	172	19	administered	administer	VERB
eurjchem-1748	172	20	intraperitoneally	intraperitoneally	ADV
eurjchem-1748	172	21	to	to	ADP
eurjchem-1748	172	22	all	all	DET
eurjchem-1748	172	23	the	the	DET
eurjchem-1748	172	24	groups	group	NOUN
eurjchem-1748	172	25	except	except	SCONJ
eurjchem-1748	172	26	control	control	NOUN
eurjchem-1748	172	27	(	(	PUNCT
eurjchem-1748	172	28	buffer	buffer	NOUN
eurjchem-1748	172	29	alone	alone	ADV
eurjchem-1748	172	30	)	)	PUNCT
eurjchem-1748	172	31	.	.	PUNCT
eurjchem-1748	173	1	after	after	ADP
eurjchem-1748	173	2	8	8	NUM
eurjchem-1748	173	3	weeks	week	NOUN
eurjchem-1748	173	4	of	of	ADP
eurjchem-1748	173	5	stz	stz	PROPN
eurjchem-1748	173	6	administration	administration	NOUN
eurjchem-1748	173	7	,	,	PUNCT
eurjchem-1748	173	8	rats	rat	NOUN
eurjchem-1748	173	9	were	be	AUX
eurjchem-1748	173	10	fasted	fast	VERB
eurjchem-1748	173	11	for	for	ADP
eurjchem-1748	173	12	12	12	NUM
eurjchem-1748	173	13	hrs	hrs	NOUN
eurjchem-1748	173	14	and	and	CCONJ
eurjchem-1748	173	15	the	the	DET
eurjchem-1748	173	16	fasting	fast	VERB
eurjchem-1748	173	17	blood	blood	NOUN
eurjchem-1748	173	18	glucose	glucose	NOUN
eurjchem-1748	173	19	levels	level	NOUN
eurjchem-1748	173	20	were	be	AUX
eurjchem-1748	173	21	measured	measure	VERB
eurjchem-1748	173	22	using	use	VERB
eurjchem-1748	173	23	tail	tail	NOUN
eurjchem-1748	173	24	vein	vein	ADJ
eurjchem-1748	173	25	method	method	NOUN
eurjchem-1748	173	26	,	,	PUNCT
eurjchem-1748	173	27	rats	rat	NOUN
eurjchem-1748	173	28	with	with	ADP
eurjchem-1748	173	29	fasting	fast	VERB
eurjchem-1748	173	30	blood	blood	NOUN
eurjchem-1748	173	31	glucose	glucose	NOUN
eurjchem-1748	173	32	levels	level	NOUN
eurjchem-1748	173	33	above	above	ADP
eurjchem-1748	173	34	250	250	NUM
eurjchem-1748	173	35	mg	mg	PROPN
eurjchem-1748	173	36	/	/	SYM
eurjchem-1748	173	37	dl	dl	PROPN
eurjchem-1748	173	38	were	be	AUX
eurjchem-1748	173	39	considered	consider	VERB
eurjchem-1748	173	40	to	to	PART
eurjchem-1748	173	41	be	be	AUX
eurjchem-1748	173	42	diabetic	diabetic	ADJ
eurjchem-1748	173	43	and	and	CCONJ
eurjchem-1748	173	44	used	use	VERB
eurjchem-1748	173	45	for	for	ADP
eurjchem-1748	173	46	the	the	DET
eurjchem-1748	173	47	study	study	NOUN
eurjchem-1748	173	48	.	.	PUNCT
eurjchem-1748	174	1	rats	rat	NOUN
eurjchem-1748	174	2	were	be	AUX
eurjchem-1748	174	3	allowed	allow	VERB
eurjchem-1748	174	4	to	to	PART
eurjchem-1748	174	5	feed	feed	VERB
eurjchem-1748	174	6	on	on	ADP
eurjchem-1748	174	7	their	their	PRON
eurjchem-1748	174	8	respective	respective	ADJ
eurjchem-1748	174	9	diets	diet	NOUN
eurjchem-1748	174	10	until	until	ADP
eurjchem-1748	174	11	the	the	DET
eurjchem-1748	174	12	end	end	NOUN
eurjchem-1748	174	13	of	of	ADP
eurjchem-1748	174	14	the	the	DET
eurjchem-1748	174	15	study	study	NOUN
eurjchem-1748	174	16	.	.	PUNCT
eurjchem-1748	175	1	2018	2018	NUM
eurjchem-1748	175	2	–	–	PUNCT
eurjchem-1748	175	3	european	european	ADJ
eurjchem-1748	175	4	journal	journal	NOUN
eurjchem-1748	175	5	of	of	ADP
eurjchem-1748	175	6	chemistry	chemistry	NOUN
eurjchem-1748	175	7	–	–	PUNCT
eurjchem-1748	175	8	cc	cc	NOUN
eurjchem-1748	175	9	by	by	ADP
eurjchem-1748	175	10	nc	nc	PROPN
eurjchem-1748	175	11	–	–	PUNCT
eurjchem-1748	175	12	doi	doi	PROPN
eurjchem-1748	175	13	:	:	PUNCT
eurjchem-1748	175	14	10.5155	10.5155	NUM
eurjchem-1748	175	15	/	/	SYM
eurjchem-1748	175	16	eurjchem.9.4.322	eurjchem.9.4.322	PROPN
eurjchem-1748	175	17	-	-	PUNCT
eurjchem-1748	175	18	330.1748	330.1748	NUM
eurjchem-1748	175	19	ankireddy	ankireddy	NOUN
eurjchem-1748	175	20	et	et	PROPN
eurjchem-1748	175	21	al	al	PROPN
eurjchem-1748	175	22	.	.	PUNCT
eurjchem-1748	175	23	/	/	SYM
eurjchem-1748	175	24	european	european	PROPN
eurjchem-1748	175	25	journal	journal	PROPN
eurjchem-1748	175	26	of	of	ADP
eurjchem-1748	175	27	chemistry	chemistry	NOUN
eurjchem-1748	175	28	9	9	NUM
eurjchem-1748	175	29	(	(	PUNCT
eurjchem-1748	175	30	4	4	NUM
eurjchem-1748	175	31	)	)	PUNCT
eurjchem-1748	175	32	(	(	PUNCT
eurjchem-1748	175	33	2018	2018	NUM
eurjchem-1748	175	34	)	)	PUNCT
eurjchem-1748	175	35	322	322	NUM
eurjchem-1748	175	36	-	-	SYM
eurjchem-1748	175	37	330	330	NUM
eurjchem-1748	175	38	327	327	NUM
eurjchem-1748	175	39	figure	figure	NOUN
eurjchem-1748	175	40	3	3	NUM
eurjchem-1748	175	41	.	.	PUNCT
eurjchem-1748	175	42	total	total	ADJ
eurjchem-1748	175	43	workflow	workflow	NOUN
eurjchem-1748	175	44	of	of	ADP
eurjchem-1748	175	45	the	the	DET
eurjchem-1748	175	46	designing	designing	NOUN
eurjchem-1748	175	47	and	and	CCONJ
eurjchem-1748	175	48	prioritizing	prioritize	VERB
eurjchem-1748	175	49	the	the	DET
eurjchem-1748	175	50	molecules	molecule	NOUN
eurjchem-1748	175	51	.	.	PUNCT
eurjchem-1748	176	1	effect	effect	NOUN
eurjchem-1748	176	2	of	of	ADP
eurjchem-1748	176	3	test	test	NOUN
eurjchem-1748	176	4	compounds	compound	NOUN
eurjchem-1748	176	5	on	on	ADP
eurjchem-1748	176	6	high	high	ADJ
eurjchem-1748	176	7	fat	fat	ADJ
eurjchem-1748	176	8	diet	diet	PROPN
eurjchem-1748	176	9	/	/	SYM
eurjchem-1748	176	10	streptozotocin	streptozotocin	PROPN
eurjchem-1748	176	11	(	(	PUNCT
eurjchem-1748	176	12	hfd	hfd	PROPN
eurjchem-1748	176	13	/	/	SYM
eurjchem-1748	176	14	stz	stz	NOUN
eurjchem-1748	176	15	)	)	PUNCT
eurjchem-1748	176	16	induced	induce	VERB
eurjchem-1748	176	17	hyperglycemic	hyperglycemic	ADJ
eurjchem-1748	176	18	rats	rat	NOUN
eurjchem-1748	176	19	:	:	PUNCT
eurjchem-1748	176	20	diabetic	diabetic	ADJ
eurjchem-1748	176	21	rats	rat	NOUN
eurjchem-1748	176	22	selected	select	VERB
eurjchem-1748	176	23	using	use	VERB
eurjchem-1748	176	24	the	the	DET
eurjchem-1748	176	25	above	above	ADJ
eurjchem-1748	176	26	procedure	procedure	NOUN
eurjchem-1748	176	27	was	be	AUX
eurjchem-1748	176	28	treated	treat	VERB
eurjchem-1748	176	29	with	with	ADP
eurjchem-1748	176	30	test	test	NOUN
eurjchem-1748	176	31	compounds	compound	NOUN
eurjchem-1748	176	32	and	and	CCONJ
eurjchem-1748	176	33	pioglitazone	pioglitazone	NOUN
eurjchem-1748	176	34	in	in	ADP
eurjchem-1748	176	35	between	between	ADP
eurjchem-1748	176	36	10	10	NUM
eurjchem-1748	176	37	-	-	SYM
eurjchem-1748	176	38	20	20	NUM
eurjchem-1748	176	39	%	%	NOUN
eurjchem-1748	176	40	.	.	PUNCT
eurjchem-1748	177	1	the	the	DET
eurjchem-1748	177	2	effect	effect	NOUN
eurjchem-1748	177	3	of	of	ADP
eurjchem-1748	177	4	the	the	DET
eurjchem-1748	177	5	test	test	NOUN
eurjchem-1748	177	6	compounds	compound	VERB
eurjchem-1748	177	7	8	8	NUM
eurjchem-1748	177	8	,	,	PUNCT
eurjchem-1748	177	9	13	13	NUM
eurjchem-1748	177	10	,	,	PUNCT
eurjchem-1748	177	11	14	14	NUM
eurjchem-1748	177	12	,	,	PUNCT
eurjchem-1748	177	13	22	22	NUM
eurjchem-1748	177	14	and	and	CCONJ
eurjchem-1748	177	15	27	27	NUM
eurjchem-1748	177	16	,	,	PUNCT
eurjchem-1748	177	17	on	on	ADP
eurjchem-1748	177	18	hfd	hfd	PROPN
eurjchem-1748	177	19	/	/	SYM
eurjchem-1748	177	20	stz	stz	NOUN
eurjchem-1748	177	21	induced	induce	VERB
eurjchem-1748	177	22	type	type	NOUN
eurjchem-1748	177	23	2	2	NUM
eurjchem-1748	177	24	diabetes	diabetes	NOUN
eurjchem-1748	177	25	mellitus	mellitus	NOUN
eurjchem-1748	177	26	was	be	AUX
eurjchem-1748	177	27	studied	study	VERB
eurjchem-1748	177	28	by	by	ADP
eurjchem-1748	177	29	administering	administer	VERB
eurjchem-1748	177	30	the	the	DET
eurjchem-1748	177	31	drugs	drug	NOUN
eurjchem-1748	177	32	at	at	ADP
eurjchem-1748	177	33	a	a	DET
eurjchem-1748	177	34	dose	dose	NOUN
eurjchem-1748	177	35	of	of	ADP
eurjchem-1748	177	36	200	200	NUM
eurjchem-1748	177	37	mg	mg	NOUN
eurjchem-1748	177	38	/	/	SYM
eurjchem-1748	177	39	kg	kg	PROPN
eurjchem-1748	177	40	bw	bw	PROPN
eurjchem-1748	177	41	p.o	p.o	PROPN
eurjchem-1748	177	42	.	.	PROPN
eurjchem-1748	177	43	and	and	CCONJ
eurjchem-1748	177	44	pioglitazone	pioglitazone	NOUN
eurjchem-1748	177	45	(	(	PUNCT
eurjchem-1748	177	46	2.7	2.7	NUM
eurjchem-1748	177	47	mg	mg	PROPN
eurjchem-1748	177	48	/	/	SYM
eurjchem-1748	177	49	kg	kg	PROPN
eurjchem-1748	177	50	p.o	p.o	PROPN
eurjchem-1748	177	51	.	.	PROPN
eurjchem-1748	177	52	)	)	PUNCT
eurjchem-1748	177	53	to	to	ADP
eurjchem-1748	177	54	the	the	DET
eurjchem-1748	177	55	positive	positive	ADJ
eurjchem-1748	177	56	control	control	NOUN
eurjchem-1748	177	57	group	group	NOUN
eurjchem-1748	177	58	for	for	ADP
eurjchem-1748	177	59	21	21	NUM
eurjchem-1748	177	60	days	day	NOUN
eurjchem-1748	177	61	(	(	PUNCT
eurjchem-1748	177	62	3	3	NUM
eurjchem-1748	177	63	weeks	week	NOUN
eurjchem-1748	177	64	)	)	PUNCT
eurjchem-1748	177	65	respecttively	respecttively	ADV
eurjchem-1748	177	66	.	.	PUNCT
eurjchem-1748	178	1	fasting	fast	VERB
eurjchem-1748	178	2	blood	blood	NOUN
eurjchem-1748	178	3	glucose	glucose	NOUN
eurjchem-1748	178	4	levels	level	NOUN
eurjchem-1748	178	5	were	be	AUX
eurjchem-1748	178	6	estimated	estimate	VERB
eurjchem-1748	178	7	using	use	VERB
eurjchem-1748	178	8	glucometer	glucometer	NOUN
eurjchem-1748	178	9	(	(	PUNCT
eurjchem-1748	178	10	accu	accu	PROPN
eurjchem-1748	178	11	-	-	ADJ
eurjchem-1748	178	12	chek	chek	ADJ
eurjchem-1748	178	13	active	active	ADJ
eurjchem-1748	178	14	tm	tm	PRON
eurjchem-1748	178	15	test	test	NOUN
eurjchem-1748	178	16	meter	meter	NOUN
eurjchem-1748	178	17	)	)	PUNCT
eurjchem-1748	178	18	on	on	ADP
eurjchem-1748	178	19	day	day	NOUN
eurjchem-1748	178	20	1	1	NUM
eurjchem-1748	178	21	,	,	PUNCT
eurjchem-1748	178	22	7	7	NUM
eurjchem-1748	178	23	,	,	PUNCT
eurjchem-1748	178	24	14	14	NUM
eurjchem-1748	178	25	and	and	CCONJ
eurjchem-1748	178	26	21	21	NUM
eurjchem-1748	178	27	.	.	PUNCT
eurjchem-1748	179	1	the	the	DET
eurjchem-1748	179	2	percentage	percentage	NOUN
eurjchem-1748	179	3	reduction	reduction	NOUN
eurjchem-1748	179	4	in	in	ADP
eurjchem-1748	179	5	blood	blood	NOUN
eurjchem-1748	179	6	glucose	glucose	NOUN
eurjchem-1748	179	7	levels	level	NOUN
eurjchem-1748	179	8	was	be	AUX
eurjchem-1748	179	9	estimated	estimate	VERB
eurjchem-1748	179	10	and	and	CCONJ
eurjchem-1748	179	11	compared	compare	VERB
eurjchem-1748	179	12	with	with	ADP
eurjchem-1748	179	13	that	that	PRON
eurjchem-1748	179	14	of	of	ADP
eurjchem-1748	179	15	normal	normal	ADJ
eurjchem-1748	179	16	control	control	NOUN
eurjchem-1748	179	17	and	and	CCONJ
eurjchem-1748	179	18	stz	stz	VERB
eurjchem-1748	179	19	treated	treat	VERB
eurjchem-1748	179	20	(	(	PUNCT
eurjchem-1748	179	21	negative	negative	ADJ
eurjchem-1748	179	22	control	control	NOUN
eurjchem-1748	179	23	)	)	PUNCT
eurjchem-1748	179	24	groups	group	NOUN
eurjchem-1748	179	25	.	.	PUNCT
eurjchem-1748	180	1	data	datum	NOUN
eurjchem-1748	180	2	represents	represent	VERB
eurjchem-1748	180	3	mean	mean	ADJ
eurjchem-1748	180	4	±sem	±sem	NOUN
eurjchem-1748	180	5	of	of	ADP
eurjchem-1748	180	6	blood	blood	NOUN
eurjchem-1748	180	7	glucose	glucose	NOUN
eurjchem-1748	180	8	levels	level	NOUN
eurjchem-1748	180	9	in	in	ADP
eurjchem-1748	180	10	rats	rat	NOUN
eurjchem-1748	180	11	treated	treat	VERB
eurjchem-1748	180	12	with	with	ADP
eurjchem-1748	180	13	test	test	NOUN
eurjchem-1748	180	14	compounds	compound	NOUN
eurjchem-1748	180	15	for	for	ADP
eurjchem-1748	180	16	21	21	NUM
eurjchem-1748	180	17	days	day	NOUN
eurjchem-1748	180	18	.	.	PUNCT
eurjchem-1748	181	1	a	a	PRON
eurjchem-1748	181	2	=	=	PUNCT
eurjchem-1748	181	3	represents	represent	VERB
eurjchem-1748	181	4	comparision	comparision	NOUN
eurjchem-1748	181	5	of	of	ADP
eurjchem-1748	181	6	blood	blood	NOUN
eurjchem-1748	181	7	glucose	glucose	NOUN
eurjchem-1748	181	8	levels	level	NOUN
eurjchem-1748	181	9	on	on	ADP
eurjchem-1748	181	10	day	day	NOUN
eurjchem-1748	181	11	7	7	NUM
eurjchem-1748	181	12	,	,	PUNCT
eurjchem-1748	181	13	14	14	NUM
eurjchem-1748	181	14	and	and	CCONJ
eurjchem-1748	181	15	21	21	NUM
eurjchem-1748	181	16	with	with	ADP
eurjchem-1748	181	17	that	that	PRON
eurjchem-1748	181	18	of	of	ADP
eurjchem-1748	181	19	day	day	NOUN
eurjchem-1748	181	20	1	1	NUM
eurjchem-1748	181	21	.	.	NOUN
eurjchem-1748	181	22	2.7	2.7	NUM
eurjchem-1748	181	23	.	.	PUNCT
eurjchem-1748	181	24	animals	animal	NOUN
eurjchem-1748	181	25	and	and	CCONJ
eurjchem-1748	181	26	induction	induction	NOUN
eurjchem-1748	181	27	of	of	ADP
eurjchem-1748	181	28	t2	t2	PROPN
eurjchem-1748	181	29	dm	dm	PROPN
eurjchem-1748	181	30	adult	adult	NOUN
eurjchem-1748	181	31	wistar	wistar	PROPN
eurjchem-1748	181	32	rats	rat	NOUN
eurjchem-1748	181	33	of	of	ADP
eurjchem-1748	181	34	either	either	DET
eurjchem-1748	181	35	sex	sex	NOUN
eurjchem-1748	181	36	(	(	PUNCT
eurjchem-1748	181	37	250	250	NUM
eurjchem-1748	181	38	-	-	SYM
eurjchem-1748	181	39	300	300	NUM
eurjchem-1748	181	40	g	g	NOUN
eurjchem-1748	181	41	)	)	PUNCT
eurjchem-1748	181	42	were	be	AUX
eurjchem-1748	181	43	procured	procure	VERB
eurjchem-1748	181	44	from	from	ADP
eurjchem-1748	181	45	the	the	DET
eurjchem-1748	181	46	animal	animal	NOUN
eurjchem-1748	181	47	house	house	NOUN
eurjchem-1748	181	48	of	of	ADP
eurjchem-1748	181	49	bapatla	bapatla	PROPN
eurjchem-1748	181	50	college	college	NOUN
eurjchem-1748	181	51	of	of	ADP
eurjchem-1748	181	52	pharmacy	pharmacy	NOUN
eurjchem-1748	181	53	(	(	PUNCT
eurjchem-1748	181	54	1032	1032	NUM
eurjchem-1748	181	55	/	/	SYM
eurjchem-1748	181	56	ac/07	ac/07	PROPN
eurjchem-1748	181	57	/	/	SYM
eurjchem-1748	181	58	cpcsea	cpcsea	NOUN
eurjchem-1748	181	59	)	)	PUNCT
eurjchem-1748	181	60	,	,	PUNCT
eurjchem-1748	181	61	bapatla	bapatla	NOUN
eurjchem-1748	181	62	,	,	PUNCT
eurjchem-1748	181	63	guntur	guntur	PROPN
eurjchem-1748	181	64	dt	dt	PROPN
eurjchem-1748	181	65	,	,	PUNCT
eurjchem-1748	181	66	india	india	PROPN
eurjchem-1748	181	67	and	and	CCONJ
eurjchem-1748	181	68	were	be	AUX
eurjchem-1748	181	69	acclimatized	acclimatize	VERB
eurjchem-1748	181	70	to	to	ADP
eurjchem-1748	181	71	laboratory	laboratory	NOUN
eurjchem-1748	181	72	conditions	condition	NOUN
eurjchem-1748	181	73	one	one	NUM
eurjchem-1748	181	74	week	week	NOUN
eurjchem-1748	181	75	prior	prior	ADV
eurjchem-1748	181	76	to	to	ADP
eurjchem-1748	181	77	initiation	initiation	NOUN
eurjchem-1748	181	78	of	of	ADP
eurjchem-1748	181	79	experiments	experiment	NOUN
eurjchem-1748	181	80	in	in	ADP
eurjchem-1748	181	81	the	the	DET
eurjchem-1748	181	82	experimental	experimental	ADJ
eurjchem-1748	181	83	area	area	NOUN
eurjchem-1748	181	84	,	,	PUNCT
eurjchem-1748	181	85	a	a	DET
eurjchem-1748	181	86	constant	constant	ADJ
eurjchem-1748	181	87	temperature	temperature	NOUN
eurjchem-1748	181	88	(	(	PUNCT
eurjchem-1748	181	89	22±1	22±1	NOUN
eurjchem-1748	181	90	°	°	PROPN
eurjchem-1748	181	91	c	c	NOUN
eurjchem-1748	181	92	)	)	PUNCT
eurjchem-1748	181	93	,	,	PUNCT
eurjchem-1748	181	94	relative	relative	ADJ
eurjchem-1748	181	95	humidity	humidity	NOUN
eurjchem-1748	181	96	(	(	PUNCT
eurjchem-1748	181	97	40	40	NUM
eurjchem-1748	181	98	-	-	SYM
eurjchem-1748	181	99	50	50	NUM
eurjchem-1748	181	100	%	%	NOUN
eurjchem-1748	181	101	)	)	PUNCT
eurjchem-1748	181	102	and	and	CCONJ
eurjchem-1748	181	103	12	12	NUM
eurjchem-1748	181	104	-	-	SYM
eurjchem-1748	181	105	12	12	NUM
eurjchem-1748	181	106	h	h	NOUN
eurjchem-1748	181	107	light	light	ADJ
eurjchem-1748	181	108	/	/	SYM
eurjchem-1748	181	109	dark	dark	ADJ
eurjchem-1748	181	110	cycles	cycle	NOUN
eurjchem-1748	181	111	were	be	AUX
eurjchem-1748	181	112	maintained	maintain	VERB
eurjchem-1748	181	113	.	.	PUNCT
eurjchem-1748	182	1	the	the	DET
eurjchem-1748	182	2	rats	rat	NOUN
eurjchem-1748	182	3	were	be	AUX
eurjchem-1748	182	4	provided	provide	VERB
eurjchem-1748	182	5	with	with	ADP
eurjchem-1748	182	6	standard	standard	ADJ
eurjchem-1748	182	7	chow	chow	PROPN
eurjchem-1748	182	8	(	(	PUNCT
eurjchem-1748	182	9	rayan	rayan	PROPN
eurjchem-1748	182	10	’s	’s	PART
eurjchem-1748	182	11	biotech	biotech	PROPN
eurjchem-1748	182	12	,	,	PUNCT
eurjchem-1748	182	13	hyderabad	hyderabad	PROPN
eurjchem-1748	182	14	)	)	PUNCT
eurjchem-1748	182	15	and	and	CCONJ
eurjchem-1748	182	16	water	water	NOUN
eurjchem-1748	182	17	ad	ad	NOUN
eurjchem-1748	182	18	libitum	libitum	PROPN
eurjchem-1748	182	19	.	.	PUNCT
eurjchem-1748	183	1	the	the	DET
eurjchem-1748	183	2	experimental	experimental	ADJ
eurjchem-1748	183	3	protocol	protocol	NOUN
eurjchem-1748	183	4	was	be	AUX
eurjchem-1748	183	5	approved	approve	VERB
eurjchem-1748	183	6	by	by	ADP
eurjchem-1748	183	7	institutional	institutional	ADJ
eurjchem-1748	183	8	animal	animal	NOUN
eurjchem-1748	183	9	ethics	ethic	NOUN
eurjchem-1748	183	10	committee	committee	NOUN
eurjchem-1748	183	11	of	of	ADP
eurjchem-1748	183	12	bapatla	bapatla	PROPN
eurjchem-1748	183	13	college	college	NOUN
eurjchem-1748	183	14	of	of	ADP
eurjchem-1748	183	15	pharmacy	pharmacy	NOUN
eurjchem-1748	183	16	,	,	PUNCT
eurjchem-1748	183	17	vide	vide	NOUN
eurjchem-1748	183	18	approval	approval	NOUN
eurjchem-1748	183	19	no	no	INTJ
eurjchem-1748	183	20	.	.	PUNCT
eurjchem-1748	184	1	iaec	iaec	NOUN
eurjchem-1748	184	2	/	/	SYM
eurjchem-1748	184	3	x/4	x/4	PROPN
eurjchem-1748	184	4	/	/	SYM
eurjchem-1748	184	5	bcop/2016	bcop/2016	PROPN
eurjchem-1748	184	6	.	.	PUNCT
eurjchem-1748	185	1	the	the	DET
eurjchem-1748	185	2	handling	handling	NOUN
eurjchem-1748	185	3	and	and	CCONJ
eurjchem-1748	185	4	care	care	NOUN
eurjchem-1748	185	5	of	of	ADP
eurjchem-1748	185	6	animals	animal	NOUN
eurjchem-1748	185	7	was	be	AUX
eurjchem-1748	185	8	performed	perform	VERB
eurjchem-1748	185	9	in	in	ADP
eurjchem-1748	185	10	accordance	accordance	NOUN
eurjchem-1748	185	11	with	with	ADP
eurjchem-1748	185	12	cpcsea	cpcsea	NOUN
eurjchem-1748	185	13	guidelines	guideline	NOUN
eurjchem-1748	185	14	for	for	ADP
eurjchem-1748	185	15	the	the	DET
eurjchem-1748	185	16	use	use	NOUN
eurjchem-1748	185	17	and	and	CCONJ
eurjchem-1748	185	18	care	care	NOUN
eurjchem-1748	185	19	of	of	ADP
eurjchem-1748	185	20	experimental	experimental	ADJ
eurjchem-1748	185	21	animals	animal	NOUN
eurjchem-1748	185	22	[	[	X
eurjchem-1748	185	23	36	36	NUM
eurjchem-1748	185	24	]	]	PUNCT
eurjchem-1748	185	25	.	.	PUNCT
eurjchem-1748	186	1	2.8	2.8	NUM
eurjchem-1748	186	2	.	.	PUNCT
eurjchem-1748	186	3	acute	acute	ADJ
eurjchem-1748	186	4	toxicity	toxicity	NOUN
eurjchem-1748	186	5	studies	study	NOUN
eurjchem-1748	186	6	acute	acute	NOUN
eurjchem-1748	186	7	toxicity	toxicity	NOUN
eurjchem-1748	186	8	studies	study	NOUN
eurjchem-1748	186	9	were	be	AUX
eurjchem-1748	186	10	performed	perform	VERB
eurjchem-1748	186	11	according	accord	VERB
eurjchem-1748	186	12	to	to	ADP
eurjchem-1748	186	13	organization	organization	NOUN
eurjchem-1748	186	14	for	for	ADP
eurjchem-1748	186	15	economic	economic	ADJ
eurjchem-1748	186	16	co	co	NOUN
eurjchem-1748	186	17	-	-	NOUN
eurjchem-1748	186	18	operation	operation	NOUN
eurjchem-1748	186	19	and	and	CCONJ
eurjchem-1748	186	20	development	development	NOUN
eurjchem-1748	186	21	(	(	PUNCT
eurjchem-1748	186	22	oecd	oecd	PROPN
eurjchem-1748	186	23	)	)	PUNCT
eurjchem-1748	186	24	guideline	guideline	NOUN
eurjchem-1748	186	25	423.test	423.t	ADJ
eurjchem-1748	186	26	compounds	compound	NOUN
eurjchem-1748	186	27	were	be	AUX
eurjchem-1748	186	28	administered	administer	VERB
eurjchem-1748	186	29	to	to	ADP
eurjchem-1748	186	30	six	six	NUM
eurjchem-1748	186	31	female	female	ADJ
eurjchem-1748	186	32	albino	albino	NOUN
eurjchem-1748	186	33	mice	mouse	NOUN
eurjchem-1748	186	34	fasted	fast	VERB
eurjchem-1748	186	35	for	for	ADP
eurjchem-1748	186	36	5hrs	5hrs	NUM
eurjchem-1748	186	37	at	at	ADP
eurjchem-1748	186	38	a	a	DET
eurjchem-1748	186	39	dose	dose	NOUN
eurjchem-1748	186	40	of	of	ADP
eurjchem-1748	186	41	2000	2000	NUM
eurjchem-1748	186	42	mg	mg	PROPN
eurjchem-1748	186	43	/	/	SYM
eurjchem-1748	186	44	kg	kg	PROPN
eurjchem-1748	186	45	body	body	NOUN
eurjchem-1748	186	46	weight	weight	NOUN
eurjchem-1748	186	47	(	(	PUNCT
eurjchem-1748	186	48	limit	limit	NOUN
eurjchem-1748	186	49	test	test	NOUN
eurjchem-1748	186	50	)	)	PUNCT
eurjchem-1748	186	51	orally	orally	ADV
eurjchem-1748	186	52	.	.	PUNCT
eurjchem-1748	187	1	the	the	DET
eurjchem-1748	187	2	test	test	NOUN
eurjchem-1748	187	3	was	be	AUX
eurjchem-1748	187	4	performed	perform	VERB
eurjchem-1748	187	5	in	in	ADP
eurjchem-1748	187	6	two	two	NUM
eurjchem-1748	187	7	steps	step	NOUN
eurjchem-1748	187	8	with	with	ADP
eurjchem-1748	187	9	three	three	NUM
eurjchem-1748	187	10	animals	animal	NOUN
eurjchem-1748	187	11	per	per	ADP
eurjchem-1748	187	12	step	step	NOUN
eurjchem-1748	187	13	.	.	PUNCT
eurjchem-1748	188	1	after	after	ADP
eurjchem-1748	188	2	each	each	DET
eurjchem-1748	188	3	step	step	NOUN
eurjchem-1748	188	4	,	,	PUNCT
eurjchem-1748	188	5	mice	mouse	NOUN
eurjchem-1748	188	6	were	be	AUX
eurjchem-1748	188	7	observed	observe	VERB
eurjchem-1748	188	8	periodically	periodically	ADV
eurjchem-1748	188	9	for	for	ADP
eurjchem-1748	188	10	24	24	NUM
eurjchem-1748	188	11	hrs	hrs	NOUN
eurjchem-1748	188	12	and	and	CCONJ
eurjchem-1748	188	13	daily	daily	ADV
eurjchem-1748	188	14	for	for	ADP
eurjchem-1748	188	15	14	14	NUM
eurjchem-1748	188	16	days	day	NOUN
eurjchem-1748	188	17	for	for	ADP
eurjchem-1748	188	18	signs	sign	NOUN
eurjchem-1748	188	19	of	of	ADP
eurjchem-1748	188	20	toxicity	toxicity	NOUN
eurjchem-1748	188	21	,	,	PUNCT
eurjchem-1748	188	22	3	3	NUM
eurjchem-1748	188	23	.	.	NOUN
eurjchem-1748	188	24	results	result	NOUN
eurjchem-1748	188	25	and	and	CCONJ
eurjchem-1748	188	26	discussion	discussion	NOUN
eurjchem-1748	188	27	3.1	3.1	NUM
eurjchem-1748	188	28	.	.	PUNCT
eurjchem-1748	189	1	molecular	molecular	ADJ
eurjchem-1748	189	2	modelling	modelling	NOUN
eurjchem-1748	189	3	and	and	CCONJ
eurjchem-1748	189	4	drug	drug	NOUN
eurjchem-1748	189	5	designing	design	VERB
eurjchem-1748	189	6	a	a	DET
eurjchem-1748	189	7	molecular	molecular	ADJ
eurjchem-1748	189	8	modeling	modeling	NOUN
eurjchem-1748	189	9	study	study	NOUN
eurjchem-1748	189	10	was	be	AUX
eurjchem-1748	189	11	conducted	conduct	VERB
eurjchem-1748	189	12	to	to	PART
eurjchem-1748	189	13	predict	predict	VERB
eurjchem-1748	189	14	the	the	DET
eurjchem-1748	189	15	binding	bind	VERB
eurjchem-1748	189	16	site	site	NOUN
eurjchem-1748	189	17	of	of	ADP
eurjchem-1748	189	18	designed	design	VERB
eurjchem-1748	189	19	molecules	molecule	NOUN
eurjchem-1748	189	20	in	in	ADP
eurjchem-1748	189	21	α	α	NOUN
eurjchem-1748	189	22	-	-	ADJ
eurjchem-1748	189	23	glucosidase	glucosidase	ADJ
eurjchem-1748	189	24	active	active	ADJ
eurjchem-1748	189	25	site	site	NOUN
eurjchem-1748	189	26	.	.	PUNCT
eurjchem-1748	190	1	the	the	DET
eurjchem-1748	190	2	ligands	ligand	NOUN
eurjchem-1748	190	3	were	be	AUX
eurjchem-1748	190	4	constructed	construct	VERB
eurjchem-1748	190	5	,	,	PUNCT
eurjchem-1748	190	6	geometrically	geometrically	ADV
eurjchem-1748	190	7	optimized	optimize	VERB
eurjchem-1748	190	8	,	,	PUNCT
eurjchem-1748	190	9	and	and	CCONJ
eurjchem-1748	190	10	docked	dock	VERB
eurjchem-1748	190	11	to	to	ADP
eurjchem-1748	190	12	the	the	DET
eurjchem-1748	190	13	x	x	ADJ
eurjchem-1748	190	14	-	-	NOUN
eurjchem-1748	190	15	ray	ray	NOUN
eurjchem-1748	190	16	structure	structure	NOUN
eurjchem-1748	190	17	of	of	ADP
eurjchem-1748	190	18	α	α	NOUN
eurjchem-1748	190	19	-	-	NOUN
eurjchem-1748	190	20	glucosidase	glucosidase	ADJ
eurjchem-1748	190	21	with	with	ADP
eurjchem-1748	190	22	high	high	ADJ
eurjchem-1748	190	23	resolution	resolution	NOUN
eurjchem-1748	190	24	(	(	PUNCT
eurjchem-1748	190	25	pdb	pdb	PROPN
eurjchem-1748	190	26	code	code	PROPN
eurjchem-1748	190	27	3wy1	3wy1	NUM
eurjchem-1748	190	28	)	)	PUNCT
eurjchem-1748	190	29	obtained	obtain	VERB
eurjchem-1748	190	30	from	from	ADP
eurjchem-1748	190	31	protein	protein	NOUN
eurjchem-1748	190	32	data	datum	NOUN
eurjchem-1748	190	33	bank	bank	NOUN
eurjchem-1748	190	34	which	which	PRON
eurjchem-1748	190	35	was	be	AUX
eurjchem-1748	190	36	used	use	VERB
eurjchem-1748	190	37	for	for	ADP
eurjchem-1748	190	38	docking	docking	NOUN
eurjchem-1748	190	39	and	and	CCONJ
eurjchem-1748	190	40	in	in	ADP
eurjchem-1748	190	41	-	-	PUNCT
eurjchem-1748	190	42	silico	silico	NOUN
eurjchem-1748	190	43	analysis	analysis	NOUN
eurjchem-1748	190	44	.	.	PUNCT
eurjchem-1748	191	1	based	base	VERB
eurjchem-1748	191	2	on	on	ADP
eurjchem-1748	191	3	insilico	insilico	NOUN
eurjchem-1748	191	4	properties	property	NOUN
eurjchem-1748	191	5	8	8	NUM
eurjchem-1748	191	6	core	core	NOUN
eurjchem-1748	191	7	(	(	PUNCT
eurjchem-1748	191	8	figure	figure	NOUN
eurjchem-1748	191	9	3	3	NUM
eurjchem-1748	191	10	)	)	PUNCT
eurjchem-1748	191	11	moieties	moiety	NOUN
eurjchem-1748	191	12	prioritized	prioritize	VERB
eurjchem-1748	191	13	for	for	ADP
eurjchem-1748	191	14	the	the	DET
eurjchem-1748	191	15	synthesis	synthesis	NOUN
eurjchem-1748	191	16	and	and	CCONJ
eurjchem-1748	191	17	biochemical	biochemical	ADJ
eurjchem-1748	191	18	studies	study	NOUN
eurjchem-1748	191	19	.	.	PUNCT
eurjchem-1748	192	1	we	we	PRON
eurjchem-1748	192	2	have	have	AUX
eurjchem-1748	192	3	generated	generate	VERB
eurjchem-1748	192	4	11,268	11,268	NUM
eurjchem-1748	192	5	unique	unique	ADJ
eurjchem-1748	192	6	building	building	NOUN
eurjchem-1748	192	7	blocks	block	NOUN
eurjchem-1748	192	8	from	from	ADP
eurjchem-1748	192	9	our	our	PRON
eurjchem-1748	192	10	in	in	ADP
eurjchem-1748	192	11	-	-	PUNCT
eurjchem-1748	192	12	house	house	NOUN
eurjchem-1748	192	13	database	database	NOUN
eurjchem-1748	192	14	,	,	PUNCT
eurjchem-1748	192	15	gvkbio	gvkbio	ADJ
eurjchem-1748	192	16	online	online	ADJ
eurjchem-1748	192	17	structure	structure	NOUN
eurjchem-1748	192	18	activity	activity	NOUN
eurjchem-1748	192	19	relation	relation	NOUN
eurjchem-1748	192	20	database	database	NOUN
eurjchem-1748	192	21	(	(	PUNCT
eurjchem-1748	192	22	gostar	gostar	NOUN
eurjchem-1748	192	23	)	)	PUNCT
eurjchem-1748	192	24	,	,	PUNCT
eurjchem-1748	192	25	and	and	CCONJ
eurjchem-1748	192	26	primary	primary	ADJ
eurjchem-1748	192	27	screening	screening	NOUN
eurjchem-1748	192	28	was	be	AUX
eurjchem-1748	192	29	forwarded	forward	VERB
eurjchem-1748	192	30	using	use	VERB
eurjchem-1748	192	31	these	these	DET
eurjchem-1748	192	32	scaffolds	scaffold	NOUN
eurjchem-1748	192	33	against	against	ADP
eurjchem-1748	192	34	α	α	NOUN
eurjchem-1748	192	35	-	-	ADJ
eurjchem-1748	192	36	glucosidase	glucosidase	ADJ
eurjchem-1748	192	37	active	active	ADJ
eurjchem-1748	192	38	site	site	NOUN
eurjchem-1748	192	39	(	(	PUNCT
eurjchem-1748	192	40	pdb	pdb	PROPN
eurjchem-1748	192	41	i	i	PROPN
eurjchem-1748	192	42	d	d	PROPN
eurjchem-1748	192	43	3wy1	3wy1	NUM
eurjchem-1748	192	44	)	)	PUNCT
eurjchem-1748	192	45	.	.	PUNCT
eurjchem-1748	193	1	based	base	VERB
eurjchem-1748	193	2	on	on	ADP
eurjchem-1748	193	3	the	the	DET
eurjchem-1748	193	4	molecular	molecular	ADJ
eurjchem-1748	193	5	interaction	interaction	NOUN
eurjchem-1748	193	6	parameters	parameter	NOUN
eurjchem-1748	193	7	between	between	ADP
eurjchem-1748	193	8	protein	protein	NOUN
eurjchem-1748	193	9	and	and	CCONJ
eurjchem-1748	193	10	molecules	molecule	NOUN
eurjchem-1748	193	11	,	,	PUNCT
eurjchem-1748	193	12	binding	bind	VERB
eurjchem-1748	193	13	profile	profile	NOUN
eurjchem-1748	193	14	,	,	PUNCT
eurjchem-1748	193	15	and	and	CCONJ
eurjchem-1748	193	16	docking	dock	VERB
eurjchem-1748	193	17	experiments	experiment	NOUN
eurjchem-1748	193	18	,	,	PUNCT
eurjchem-1748	193	19	eight	eight	NUM
eurjchem-1748	193	20	quinazoline	quinazoline	NOUN
eurjchem-1748	193	21	molecular	molecular	ADJ
eurjchem-1748	193	22	frames	frame	NOUN
eurjchem-1748	193	23	were	be	AUX
eurjchem-1748	193	24	selected	select	VERB
eurjchem-1748	193	25	for	for	ADP
eurjchem-1748	193	26	sar	sar	NOUN
eurjchem-1748	193	27	for	for	ADP
eurjchem-1748	193	28	the	the	DET
eurjchem-1748	193	29	bio	bio	NOUN
eurjchem-1748	193	30	-	-	NOUN
eurjchem-1748	193	31	evaluation	evaluation	NOUN
eurjchem-1748	193	32	of	of	ADP
eurjchem-1748	193	33	α	α	NOUN
eurjchem-1748	193	34	-	-	PUNCT
eurjchem-1748	193	35	glucosidase	glucosidase	ADJ
eurjchem-1748	193	36	enzyme	enzyme	NOUN
eurjchem-1748	193	37	[	[	NOUN
eurjchem-1748	193	38	4	4	NUM
eurjchem-1748	193	39	]	]	PUNCT
eurjchem-1748	193	40	.	.	PUNCT
eurjchem-1748	194	1	acarbose	acarbose	NOUN
eurjchem-1748	194	2	which	which	PRON
eurjchem-1748	194	3	is	be	AUX
eurjchem-1748	194	4	considered	consider	VERB
eurjchem-1748	194	5	as	as	ADP
eurjchem-1748	194	6	reference	reference	NOUN
eurjchem-1748	194	7	molecule	molecule	NOUN
eurjchem-1748	194	8	while	while	SCONJ
eurjchem-1748	194	9	designing	design	VERB
eurjchem-1748	194	10	in	in	ADP
eurjchem-1748	194	11	this	this	DET
eurjchem-1748	194	12	study	study	NOUN
eurjchem-1748	194	13	showed	show	VERB
eurjchem-1748	194	14	vital	vital	ADJ
eurjchem-1748	194	15	interactions	interaction	NOUN
eurjchem-1748	194	16	with	with	ADP
eurjchem-1748	194	17	active	active	ADJ
eurjchem-1748	194	18	site	site	NOUN
eurjchem-1748	194	19	of	of	ADP
eurjchem-1748	194	20	the	the	DET
eurjchem-1748	194	21	α	α	NOUN
eurjchem-1748	194	22	-	-	NOUN
eurjchem-1748	194	23	glucosidase	glucosidase	NOUN
eurjchem-1748	194	24	.	.	PUNCT
eurjchem-1748	195	1	the	the	DET
eurjchem-1748	195	2	interactive	interactive	ADJ
eurjchem-1748	195	3	residues	residue	NOUN
eurjchem-1748	195	4	for	for	ADP
eurjchem-1748	195	5	αglucosidase	αglucosidase	NOUN
eurjchem-1748	195	6	are	be	AUX
eurjchem-1748	195	7	asp357	asp357	ADJ
eurjchem-1748	195	8	,	,	PUNCT
eurjchem-1748	195	9	ile358	ile358	PROPN
eurjchem-1748	195	10	,	,	PUNCT
eurjchem-1748	195	11	ile396	ile396	PROPN
eurjchem-1748	195	12	,	,	PUNCT
eurjchem-1748	195	13	trp432	trp432	PROPN
eurjchem-1748	195	14	,	,	PUNCT
eurjchem-1748	195	15	ash398	ash398	PROPN
eurjchem-1748	195	16	,	,	PUNCT
eurjchem-1748	195	17	ser474	ser474	PROPN
eurjchem-1748	195	18	,	,	PUNCT
eurjchem-1748	195	19	phe601	phe601	PROPN
eurjchem-1748	195	20	,	,	PUNCT
eurjchem-1748	195	21	ala602	ala602	PROPN
eurjchem-1748	195	22	,	,	PUNCT
eurjchem-1748	195	23	ser474	ser474	PROPN
eurjchem-1748	195	24	,	,	PUNCT
eurjchem-1748	195	25	phe476	phe476	PROPN
eurjchem-1748	195	26	,	,	PUNCT
eurjchem-1748	195	27	asp232	asp232	PROPN
eurjchem-1748	195	28	,	,	PUNCT
eurjchem-1748	195	29	ile233	ile233	PROPN
eurjchem-1748	195	30	,	,	PUNCT
eurjchem-1748	195	31	arg572	arg572	PROPN
eurjchem-1748	195	32	,	,	PUNCT
eurjchem-1748	195	33	ala234	ala234	PROPN
eurjchem-1748	195	34	,	,	PUNCT
eurjchem-1748	195	35	phe236	phe236	PROPN
eurjchem-1748	195	36	,	,	PUNCT
eurjchem-1748	195	37	asn237	asn237	PROPN
eurjchem-1748	195	38	,	,	PUNCT
eurjchem-1748	195	39	leu240	leu240	PROPN
eurjchem-1748	195	40	,	,	PUNCT
eurjchem-1748	195	41	tyr240	tyr240	NOUN
eurjchem-1748	195	42	,	,	PUNCT
eurjchem-1748	195	43	trp329	trp329	PROPN
eurjchem-1748	195	44	,	,	PUNCT
eurjchem-1748	195	45	met470	met470	PROPN
eurjchem-1748	195	46	,	,	PUNCT
eurjchem-1748	195	47	asp469	asp469	PROPN
eurjchem-1748	195	48	,	,	PUNCT
eurjchem-1748	195	49	trp467	trp467	PROPN
eurjchem-1748	195	50	,	,	PUNCT
eurjchem-1748	195	51	trp565	trp565	PROPN
eurjchem-1748	195	52	,	,	PUNCT
eurjchem-1748	195	53	arg552	arg552	NOUN
eurjchem-1748	195	54	,	,	PUNCT
eurjchem-1748	195	55	gly567	gly567	PROPN
eurjchem-1748	195	56	,	,	PUNCT
eurjchem-1748	195	57	asp568	asp568	PROPN
eurjchem-1748	195	58	,	,	PUNCT
eurjchem-1748	195	59	arg624	arg624	PROPN
eurjchem-1748	195	60	,	,	PUNCT
eurjchem-1748	195	61	asp597	asp597	PROPN
eurjchem-1748	195	62	,	,	PUNCT
eurjchem-1748	195	63	his626	his626	PROPN
eurjchem-1748	195	64	,	,	PUNCT
eurjchem-1748	195	65	ala628	ala628	PROPN
eurjchem-1748	195	66	,	,	PUNCT
eurjchem-1748	195	67	asp537	asp537	NOUN
eurjchem-1748	195	68	,	,	PUNCT
eurjchem-1748	195	69	and	and	CCONJ
eurjchem-1748	195	70	ile358.among	ile358.among	PUNCT
eurjchem-1748	195	71	those	those	PRON
eurjchem-1748	195	72	above	above	ADP
eurjchem-1748	195	73	interactive	interactive	ADJ
eurjchem-1748	195	74	residues	residue	NOUN
eurjchem-1748	195	75	asp357	asp357	ADJ
eurjchem-1748	195	76	,	,	PUNCT
eurjchem-1748	195	77	asp232	asp232	PROPN
eurjchem-1748	195	78	,	,	PUNCT
eurjchem-1748	195	79	asp	asp	PROPN
eurjchem-1748	195	80	237	237	NUM
eurjchem-1748	195	81	,	,	PUNCT
eurjchem-1748	195	82	asp568	asp568	PROPN
eurjchem-1748	195	83	,	,	PUNCT
eurjchem-1748	195	84	arg552	arg552	PROPN
eurjchem-1748	195	85	and	and	CCONJ
eurjchem-1748	195	86	his626	his626	PROPN
eurjchem-1748	195	87	,	,	PUNCT
eurjchem-1748	195	88	have	have	AUX
eurjchem-1748	195	89	formed	form	VERB
eurjchem-1748	195	90	hydrogen	hydrogen	NOUN
eurjchem-1748	195	91	bond	bond	NOUN
eurjchem-1748	195	92	with	with	ADP
eurjchem-1748	195	93	acarbose	acarbose	NOUN
eurjchem-1748	195	94	(	(	PUNCT
eurjchem-1748	195	95	figure	figure	NOUN
eurjchem-1748	195	96	4	4	NUM
eurjchem-1748	195	97	)	)	PUNCT
eurjchem-1748	195	98	,	,	PUNCT
eurjchem-1748	195	99	is	be	AUX
eurjchem-1748	195	100	showing	show	VERB
eurjchem-1748	195	101	interactive	interactive	ADJ
eurjchem-1748	195	102	resides	reside	VERB
eurjchem-1748	195	103	between	between	ADP
eurjchem-1748	195	104	the	the	DET
eurjchem-1748	195	105	α	α	NOUN
eurjchem-1748	195	106	-	-	PUNCT
eurjchem-1748	195	107	glucosidase	glucosidase	ADJ
eurjchem-1748	195	108	and	and	CCONJ
eurjchem-1748	195	109	molecule	molecule	NOUN
eurjchem-1748	195	110	16	16	NUM
eurjchem-1748	195	111	also	also	ADV
eurjchem-1748	195	112	showing	show	VERB
eurjchem-1748	195	113	similar	similar	ADJ
eurjchem-1748	195	114	interactions	interaction	NOUN
eurjchem-1748	195	115	like	like	ADP
eurjchem-1748	195	116	acarbose	acarbose	NOUN
eurjchem-1748	195	117	,	,	PUNCT
eurjchem-1748	195	118	those	those	PRON
eurjchem-1748	195	119	are	be	AUX
eurjchem-1748	195	120	phe37	phe37	NOUN
eurjchem-1748	195	121	,	,	PUNCT
eurjchem-1748	195	122	gly399	gly399	PROPN
eurjchem-1748	195	123	,	,	PUNCT
eurjchem-1748	195	124	tyr389	tyr389	PROPN
eurjchem-1748	195	125	,	,	PUNCT
eurjchem-1748	195	126	arg400	arg400	PROPN
eurjchem-1748	195	127	,	,	PUNCT
eurjchem-1748	195	128	val339	val339	PROPN
eurjchem-1748	195	129	,	,	PUNCT
eurjchem-1748	195	130	asp333	asp333	PROPN
eurjchem-1748	195	131	,	,	PUNCT
eurjchem-1748	195	132	his332	his332	PROPN
eurjchem-1748	195	133	,	,	PUNCT
eurjchem-1748	195	134	arg404	arg404	NOUN
eurjchem-1748	195	135	,	,	PUNCT
eurjchem-1748	195	136	val102	val102	ADJ
eurjchem-1748	195	137	,	,	PUNCT
eurjchem-1748	195	138	tyr65	tyr65	NOUN
eurjchem-1748	195	139	,	,	PUNCT
eurjchem-1748	195	140	his105	his105	PROPN
eurjchem-1748	195	141	,	,	PUNCT
eurjchem-1748	195	142	phe166	phe166	PROPN
eurjchem-1748	195	143	,	,	PUNCT
eurjchem-1748	195	144	arg200	arg200	PROPN
eurjchem-1748	195	145	,	,	PUNCT
eurjchem-1748	195	146	gln170	gln170	PROPN
eurjchem-1748	195	147	,	,	PUNCT
eurjchem-1748	195	148	ash202	ash202	PROPN
eurjchem-1748	195	149	,	,	PUNCT
eurjchem-1748	195	150	phe147	phe147	NOUN
eurjchem-1748	195	151	,	,	PUNCT
eurjchem-1748	195	152	ile146	ile146	PROPN
eurjchem-1748	195	153	,	,	PUNCT
eurjchem-1748	195	154	asp202	asp202	PROPN
eurjchem-1748	195	155	,	,	PUNCT
eurjchem-1748	195	156	thr203	thr203	PROPN
eurjchem-1748	195	157	,	,	PUNCT
eurjchem-1748	195	158	asn205	asn205	PROPN
eurjchem-1748	195	159	,	,	PUNCT
eurjchem-1748	195	160	phe206	phe206	PROPN
eurjchem-1748	195	161	,	,	PUNCT
eurjchem-1748	195	162	thr226	thr226	PROPN
eurjchem-1748	195	163	,	,	PUNCT
eurjchem-1748	195	164	leu227	leu227	PROPN
eurjchem-1748	195	165	,	,	PUNCT
eurjchem-1748	195	166	gly228	gly228	PROPN
eurjchem-1748	195	167	,	,	PUNCT
eurjchem-1748	195	168	ala229	ala229	PROPN
eurjchem-1748	195	169	,	,	PUNCT
eurjchem-1748	195	170	pro230	pro230	PROPN
eurjchem-1748	195	171	,	,	PUNCT
eurjchem-1748	195	172	phe297	phe297	PROPN
eurjchem-1748	195	173	,	,	PUNCT
eurjchem-1748	195	174	asn301	asn301	PROPN
eurjchem-1748	195	175	,	,	PUNCT
eurjchem-1748	195	176	2018	2018	NUM
eurjchem-1748	195	177	–	–	PUNCT
eurjchem-1748	195	178	european	european	ADJ
eurjchem-1748	195	179	journal	journal	NOUN
eurjchem-1748	195	180	of	of	ADP
eurjchem-1748	195	181	chemistry	chemistry	NOUN
eurjchem-1748	195	182	–	–	PUNCT
eurjchem-1748	195	183	cc	cc	NOUN
eurjchem-1748	195	184	by	by	ADP
eurjchem-1748	195	185	nc	nc	PROPN
eurjchem-1748	195	186	–	–	PUNCT
eurjchem-1748	195	187	doi	doi	PROPN
eurjchem-1748	195	188	:	:	PUNCT
eurjchem-1748	195	189	10.5155	10.5155	NUM
eurjchem-1748	195	190	/	/	SYM
eurjchem-1748	195	191	eurjchem.9.4.322	eurjchem.9.4.322	PROPN
eurjchem-1748	195	192	-	-	PUNCT
eurjchem-1748	195	193	330.1748	330.1748	NUM
eurjchem-1748	195	194	328	328	NUM
eurjchem-1748	195	195	ankireddy	ankireddy	NOUN
eurjchem-1748	195	196	et	et	PROPN
eurjchem-1748	195	197	al	al	PROPN
eurjchem-1748	195	198	.	.	PUNCT
eurjchem-1748	195	199	/	/	SYM
eurjchem-1748	195	200	european	european	PROPN
eurjchem-1748	195	201	journal	journal	PROPN
eurjchem-1748	195	202	of	of	ADP
eurjchem-1748	195	203	chemistry	chemistry	NOUN
eurjchem-1748	195	204	9	9	NUM
eurjchem-1748	195	205	(	(	PUNCT
eurjchem-1748	195	206	4	4	NUM
eurjchem-1748	195	207	)	)	PUNCT
eurjchem-1748	195	208	(	(	PUNCT
eurjchem-1748	195	209	2018	2018	NUM
eurjchem-1748	195	210	)	)	PUNCT
eurjchem-1748	195	211	322	322	NUM
eurjchem-1748	195	212	-	-	SYM
eurjchem-1748	195	213	330	330	NUM
eurjchem-1748	195	214	table	table	NOUN
eurjchem-1748	195	215	2	2	NUM
eurjchem-1748	195	216	.	.	PUNCT
eurjchem-1748	196	1	ic50	ic50	PROPN
eurjchem-1748	196	2	values	value	NOUN
eurjchem-1748	196	3	(	(	PUNCT
eurjchem-1748	196	4	μm	μm	NUM
eurjchem-1748	196	5	)	)	PUNCT
eurjchem-1748	196	6	,	,	PUNCT
eurjchem-1748	196	7	dock	dock	NOUN
eurjchem-1748	196	8	scores	score	NOUN
eurjchem-1748	196	9	for	for	ADP
eurjchem-1748	196	10	7	7	NUM
eurjchem-1748	196	11	-	-	PUNCT
eurjchem-1748	196	12	r(different	r(different	NOUN
eurjchem-1748	196	13	aromatic	aromatic	ADJ
eurjchem-1748	196	14	substituents)-2	substituents)-2	NOUN
eurjchem-1748	196	15	-	-	PUNCT
eurjchem-1748	196	16	morpholino	morpholino	NOUN
eurjchem-1748	196	17	-	-	PUNCT
eurjchem-1748	196	18	n-(pyridin-2	n-(pyridin-2	NUM
eurjchem-1748	196	19	-	-	PUNCT
eurjchem-1748	196	20	ylmethyl)quinazolin-4	ylmethyl)quinazolin-4	NOUN
eurjchem-1748	196	21	-	-	PUNCT
eurjchem-1748	196	22	amine	amine	ADJ
eurjchem-1748	196	23	derivatives	derivative	NOUN
eurjchem-1748	196	24	against	against	ADP
eurjchem-1748	196	25	αglucosidase	αglucosidase	NOUN
eurjchem-1748	196	26	.	.	PUNCT
eurjchem-1748	197	1	compound	compound	VERB
eurjchem-1748	197	2	no	no	DET
eurjchem-1748	197	3	r1	r1	PROPN
eurjchem-1748	197	4	ic50	ic50	PROPN
eurjchem-1748	197	5	(	(	PUNCT
eurjchem-1748	197	6	μm	μm	NOUN
eurjchem-1748	197	7	)	)	PUNCT
eurjchem-1748	197	8	of	of	ADP
eurjchem-1748	197	9	α	α	NOUN
eurjchem-1748	197	10	-	-	PUNCT
eurjchem-1748	197	11	glucosidase	glucosidase	ADJ
eurjchem-1748	197	12	docking	docking	NOUN
eurjchem-1748	197	13	score	score	NOUN
eurjchem-1748	197	14	8	8	NUM
eurjchem-1748	197	15	phenyl	phenyl	NOUN
eurjchem-1748	197	16	1.323	1.323	NUM
eurjchem-1748	197	17	-8.1	-8.1	ADP
eurjchem-1748	197	18	9	9	NUM
eurjchem-1748	197	19	2	2	NUM
eurjchem-1748	197	20	-	-	PUNCT
eurjchem-1748	197	21	methyl	methyl	NOUN
eurjchem-1748	197	22	-	-	PUNCT
eurjchem-1748	197	23	phenyl	phenyl	NOUN
eurjchem-1748	197	24	na	na	NOUN
eurjchem-1748	197	25	-6.3	-6.3	NUM
eurjchem-1748	197	26	10	10	NUM
eurjchem-1748	197	27	4	4	NUM
eurjchem-1748	197	28	-	-	PUNCT
eurjchem-1748	197	29	fluoro	fluoro	NOUN
eurjchem-1748	197	30	-	-	PUNCT
eurjchem-1748	197	31	phenyl	phenyl	NOUN
eurjchem-1748	197	32	na	na	NOUN
eurjchem-1748	197	33	-5.7	-5.7	NOUN
eurjchem-1748	197	34	11	11	NUM
eurjchem-1748	197	35	2	2	NUM
eurjchem-1748	197	36	-	-	PUNCT
eurjchem-1748	197	37	methoxy	methoxy	ADJ
eurjchem-1748	197	38	-	-	PUNCT
eurjchem-1748	197	39	phenyl	phenyl	NOUN
eurjchem-1748	197	40	na	na	NOUN
eurjchem-1748	197	41	-6.3	-6.3	NUM
eurjchem-1748	197	42	12	12	NUM
eurjchem-1748	197	43	4	4	NUM
eurjchem-1748	197	44	-	-	PUNCT
eurjchem-1748	197	45	methoxy	methoxy	ADJ
eurjchem-1748	197	46	-	-	PUNCT
eurjchem-1748	197	47	phenyl	phenyl	NOUN
eurjchem-1748	197	48	na	na	ADP
eurjchem-1748	197	49	-5.9	-5.9	NOUN
eurjchem-1748	197	50	13	13	NUM
eurjchem-1748	197	51	4	4	NUM
eurjchem-1748	197	52	-	-	PUNCT
eurjchem-1748	197	53	bi	bi	NOUN
eurjchem-1748	197	54	-	-	NOUN
eurjchem-1748	197	55	phenyl	phenyl	NOUN
eurjchem-1748	197	56	1.310	1.310	NUM
eurjchem-1748	197	57	-8.1	-8.1	NUM
eurjchem-1748	197	58	14	14	NUM
eurjchem-1748	197	59	3	3	NUM
eurjchem-1748	197	60	-	-	PUNCT
eurjchem-1748	197	61	methoxy	methoxy	ADJ
eurjchem-1748	197	62	-	-	PUNCT
eurjchem-1748	197	63	phenyl	phenyl	NOUN
eurjchem-1748	197	64	1.122	1.122	NUM
eurjchem-1748	197	65	-8.2	-8.2	NOUN
eurjchem-1748	197	66	15	15	NUM
eurjchem-1748	197	67	3,4	3,4	NUM
eurjchem-1748	197	68	-	-	PUNCT
eurjchem-1748	197	69	dimethoxy	dimethoxy	ADJ
eurjchem-1748	197	70	-	-	PUNCT
eurjchem-1748	197	71	phenyl	phenyl	NOUN
eurjchem-1748	197	72	na	na	ADP
eurjchem-1748	197	73	-4.6	-4.6	NOUN
eurjchem-1748	197	74	16	16	NUM
eurjchem-1748	197	75	4	4	NUM
eurjchem-1748	197	76	-	-	PUNCT
eurjchem-1748	197	77	cyanophenyl	cyanophenyl	NOUN
eurjchem-1748	197	78	1.218	1.218	NUM
eurjchem-1748	197	79	-7.9	-7.9	NOUN
eurjchem-1748	197	80	17	17	NUM
eurjchem-1748	197	81	3	3	NUM
eurjchem-1748	197	82	-	-	PUNCT
eurjchem-1748	197	83	biphenyl	biphenyl	NOUN
eurjchem-1748	197	84	na	na	ADP
eurjchem-1748	197	85	-5.7	-5.7	NOUN
eurjchem-1748	197	86	18	18	NUM
eurjchem-1748	197	87	6	6	NUM
eurjchem-1748	197	88	-	-	PUNCT
eurjchem-1748	197	89	1h	1h	NUM
eurjchem-1748	197	90	-	-	PUNCT
eurjchem-1748	197	91	indole	indole	NOUN
eurjchem-1748	197	92	na	na	NOUN
eurjchem-1748	197	93	-5.4	-5.4	PROPN
eurjchem-1748	197	94	19	19	NUM
eurjchem-1748	197	95	5	5	NUM
eurjchem-1748	197	96	-	-	PUNCT
eurjchem-1748	197	97	methylbenzo(1,3)dioxole	methylbenzo(1,3)dioxole	NOUN
eurjchem-1748	197	98	na	na	NOUN
eurjchem-1748	197	99	-6.1	-6.1	PROPN
eurjchem-1748	197	100	20	20	NUM
eurjchem-1748	197	101	5	5	NUM
eurjchem-1748	197	102	-	-	PUNCT
eurjchem-1748	197	103	1h	1h	NUM
eurjchem-1748	197	104	-	-	PUNCT
eurjchem-1748	197	105	indole	indole	NOUN
eurjchem-1748	197	106	na	na	ADP
eurjchem-1748	197	107	-6.0	-6.0	PROPN
eurjchem-1748	197	108	21	21	NUM
eurjchem-1748	197	109	3	3	NUM
eurjchem-1748	197	110	-	-	PUNCT
eurjchem-1748	197	111	cyanophenyl	cyanophenyl	NOUN
eurjchem-1748	197	112	na	na	PART
eurjchem-1748	197	113	-4.6	-4.6	NOUN
eurjchem-1748	197	114	22	22	NUM
eurjchem-1748	197	115	2	2	NUM
eurjchem-1748	197	116	-	-	PUNCT
eurjchem-1748	197	117	carboxylicphenyl	carboxylicphenyl	NOUN
eurjchem-1748	197	118	2.349	2.349	NUM
eurjchem-1748	197	119	-8.1	-8.1	NUM
eurjchem-1748	197	120	23	23	NUM
eurjchem-1748	197	121	2	2	NUM
eurjchem-1748	197	122	-	-	PUNCT
eurjchem-1748	197	123	napthyl	napthyl	NOUN
eurjchem-1748	197	124	na	na	NOUN
eurjchem-1748	197	125	-7.7	-7.7	ADJ
eurjchem-1748	197	126	24	24	NUM
eurjchem-1748	197	127	1	1	NUM
eurjchem-1748	197	128	-	-	PUNCT
eurjchem-1748	197	129	napthyl	napthyl	NOUN
eurjchem-1748	198	1	na	na	NOUN
eurjchem-1748	198	2	-5.3	-5.3	PROPN
eurjchem-1748	199	1	25	25	NUM
eurjchem-1748	199	2	3	3	NUM
eurjchem-1748	199	3	-	-	PUNCT
eurjchem-1748	199	4	benzofuran	benzofuran	VERB
eurjchem-1748	199	5	2.140	2.140	NUM
eurjchem-1748	199	6	-8.1	-8.1	NUM
eurjchem-1748	199	7	26	26	NUM
eurjchem-1748	199	8	4	4	NUM
eurjchem-1748	199	9	-	-	PUNCT
eurjchem-1748	199	10	methyl-3	methyl-3	NUM
eurjchem-1748	199	11	-	-	PUNCT
eurjchem-1748	199	12	amino	amino	NOUN
eurjchem-1748	199	13	-	-	PUNCT
eurjchem-1748	199	14	phenyl	phenyl	NOUN
eurjchem-1748	199	15	2.227	2.227	NUM
eurjchem-1748	199	16	-8.0	-8.0	SYM
eurjchem-1748	199	17	27	27	NUM
eurjchem-1748	199	18	2,4	2,4	NUM
eurjchem-1748	199	19	-	-	PUNCT
eurjchem-1748	199	20	dimethoxy	dimethoxy	ADJ
eurjchem-1748	199	21	-	-	PUNCT
eurjchem-1748	199	22	phenyl	phenyl	NOUN
eurjchem-1748	199	23	1.299	1.299	NUM
eurjchem-1748	199	24	-8.2	-8.2	NOUN
eurjchem-1748	199	25	acarbose	acarbose	PROPN
eurjchem-1748	199	26	standard	standard	PROPN
eurjchem-1748	199	27	drug	drug	PROPN
eurjchem-1748	199	28	0.586	0.586	NUM
eurjchem-1748	199	29	-7.0	-7.0	PROPN
eurjchem-1748	199	30	(	(	PUNCT
eurjchem-1748	199	31	a	a	NOUN
eurjchem-1748	199	32	)	)	PUNCT
eurjchem-1748	199	33	(	(	PUNCT
eurjchem-1748	199	34	b	b	X
eurjchem-1748	199	35	)	)	PUNCT
eurjchem-1748	199	36	(	(	PUNCT
eurjchem-1748	199	37	c	c	X
eurjchem-1748	199	38	)	)	PUNCT
eurjchem-1748	199	39	figure	figure	NOUN
eurjchem-1748	199	40	4	4	NUM
eurjchem-1748	199	41	.	.	PUNCT
eurjchem-1748	200	1	(	(	PUNCT
eurjchem-1748	200	2	a	a	X
eurjchem-1748	200	3	)	)	PUNCT
eurjchem-1748	200	4	predicted	predict	VERB
eurjchem-1748	200	5	orientation	orientation	NOUN
eurjchem-1748	200	6	of	of	ADP
eurjchem-1748	200	7	the	the	DET
eurjchem-1748	200	8	lower	low	ADJ
eurjchem-1748	200	9	energy	energy	NOUN
eurjchem-1748	200	10	conformation	conformation	NOUN
eurjchem-1748	200	11	docked	dock	VERB
eurjchem-1748	200	12	poses	pose	NOUN
eurjchem-1748	200	13	of	of	ADP
eurjchem-1748	200	14	all	all	DET
eurjchem-1748	200	15	high	high	ADJ
eurjchem-1748	200	16	score	score	NOUN
eurjchem-1748	200	17	molecules	molecule	NOUN
eurjchem-1748	200	18	.	.	PUNCT
eurjchem-1748	201	1	the	the	DET
eurjchem-1748	201	2	binding	bind	VERB
eurjchem-1748	201	3	site	site	NOUN
eurjchem-1748	201	4	was	be	AUX
eurjchem-1748	201	5	enlarged	enlarge	VERB
eurjchem-1748	201	6	to	to	PART
eurjchem-1748	201	7	show	show	VERB
eurjchem-1748	201	8	hydrogen	hydrogen	NOUN
eurjchem-1748	201	9	bonding	bonding	NOUN
eurjchem-1748	201	10	(	(	PUNCT
eurjchem-1748	201	11	yellow	yellow	ADJ
eurjchem-1748	201	12	color	color	NOUN
eurjchem-1748	201	13	)	)	PUNCT
eurjchem-1748	201	14	,	,	PUNCT
eurjchem-1748	201	15	centroid	centroid	NOUN
eurjchem-1748	201	16	of	of	ADP
eurjchem-1748	201	17	the	the	DET
eurjchem-1748	201	18	aromatic	aromatic	ADJ
eurjchem-1748	201	19	ring	ring	NOUN
eurjchem-1748	201	20	interactions	interaction	NOUN
eurjchem-1748	201	21	(	(	PUNCT
eurjchem-1748	201	22	green	green	ADJ
eurjchem-1748	201	23	color	color	NOUN
eurjchem-1748	201	24	)	)	PUNCT
eurjchem-1748	201	25	between	between	ADP
eurjchem-1748	201	26	the	the	DET
eurjchem-1748	201	27	amino	amino	NOUN
eurjchem-1748	201	28	acid	acid	NOUN
eurjchem-1748	201	29	residues	residue	NOUN
eurjchem-1748	201	30	and	and	CCONJ
eurjchem-1748	201	31	best	well	ADV
eurjchem-1748	201	32	ranked	rank	VERB
eurjchem-1748	201	33	molecules	molecule	NOUN
eurjchem-1748	201	34	.	.	PUNCT
eurjchem-1748	202	1	amino	amino	NOUN
eurjchem-1748	202	2	acid	acid	NOUN
eurjchem-1748	202	3	residues	residue	NOUN
eurjchem-1748	202	4	that	that	PRON
eurjchem-1748	202	5	form	form	VERB
eurjchem-1748	202	6	hydrogen	hydrogen	NOUN
eurjchem-1748	202	7	bonds	bond	NOUN
eurjchem-1748	202	8	with	with	ADP
eurjchem-1748	202	9	compound	compound	NOUN
eurjchem-1748	202	10	13	13	NUM
eurjchem-1748	202	11	,	,	PUNCT
eurjchem-1748	202	12	and	and	CCONJ
eurjchem-1748	202	13	it	it	PRON
eurjchem-1748	202	14	has	have	AUX
eurjchem-1748	202	15	shown	show	VERB
eurjchem-1748	202	16	ball	ball	NOUN
eurjchem-1748	202	17	and	and	CCONJ
eurjchem-1748	202	18	stick	stick	VERB
eurjchem-1748	202	19	blue	blue	ADJ
eurjchem-1748	202	20	color	color	NOUN
eurjchem-1748	202	21	carbon	carbon	NOUN
eurjchem-1748	202	22	skeleton	skeleton	NOUN
eurjchem-1748	202	23	.	.	PUNCT
eurjchem-1748	203	1	(	(	PUNCT
eurjchem-1748	203	2	b	b	X
eurjchem-1748	203	3	)	)	PUNCT
eurjchem-1748	203	4	2d	2d	PROPN
eurjchem-1748	203	5	model	model	NOUN
eurjchem-1748	203	6	:	:	PUNCT
eurjchem-1748	203	7	interactive	interactive	ADJ
eurjchem-1748	203	8	residues	residue	NOUN
eurjchem-1748	203	9	with	with	ADP
eurjchem-1748	203	10	molecule	molecule	NOUN
eurjchem-1748	203	11	13	13	NUM
eurjchem-1748	203	12	.	.	PUNCT
eurjchem-1748	204	1	(	(	PUNCT
eurjchem-1748	204	2	c	c	X
eurjchem-1748	204	3	)	)	PUNCT
eurjchem-1748	204	4	overlay	overlay	NOUN
eurjchem-1748	204	5	of	of	ADP
eurjchem-1748	204	6	all	all	DET
eurjchem-1748	204	7	best	well	ADV
eurjchem-1748	204	8	scored	score	VERB
eurjchem-1748	204	9	molecules	molecule	NOUN
eurjchem-1748	204	10	in	in	ADP
eurjchem-1748	204	11	the	the	DET
eurjchem-1748	204	12	active	active	ADJ
eurjchem-1748	204	13	site	site	NOUN
eurjchem-1748	204	14	of	of	ADP
eurjchem-1748	204	15	α	α	NOUN
eurjchem-1748	204	16	-	-	PUNCT
eurjchem-1748	204	17	glucosidase	glucosidase	NOUN
eurjchem-1748	204	18	.	.	PUNCT
eurjchem-1748	205	1	glu271	glu271	NOUN
eurjchem-1748	205	2	and	and	CCONJ
eurjchem-1748	205	3	ile272	ile272	PROPN
eurjchem-1748	205	4	.	.	PUNCT
eurjchem-1748	206	1	among	among	ADP
eurjchem-1748	206	2	these	these	PRON
eurjchem-1748	206	3	,	,	PUNCT
eurjchem-1748	206	4	arg200	arg200	PROPN
eurjchem-1748	206	5	has	have	VERB
eurjchem-1748	206	6	centroid	centroid	NOUN
eurjchem-1748	206	7	interactions	interaction	NOUN
eurjchem-1748	206	8	with	with	ADP
eurjchem-1748	206	9	quinazoline	quinazoline	ADJ
eurjchem-1748	206	10	part	part	NOUN
eurjchem-1748	206	11	of	of	ADP
eurjchem-1748	206	12	the	the	DET
eurjchem-1748	206	13	molecule	molecule	NOUN
eurjchem-1748	206	14	and	and	CCONJ
eurjchem-1748	206	15	having	have	VERB
eurjchem-1748	206	16	within	within	ADP
eurjchem-1748	206	17	allowed	allow	VERB
eurjchem-1748	206	18	distance	distance	NOUN
eurjchem-1748	206	19	(	(	PUNCT
eurjchem-1748	206	20	2.5	2.5	NUM
eurjchem-1748	206	21	-	-	SYM
eurjchem-1748	206	22	3.5	3.5	NUM
eurjchem-1748	206	23	å	å	NOUN
eurjchem-1748	206	24	)	)	PUNCT
eurjchem-1748	206	25	further	far	ADV
eurjchem-1748	206	26	it	it	PRON
eurjchem-1748	206	27	is	be	AUX
eurjchem-1748	206	28	also	also	ADV
eurjchem-1748	206	29	making	make	VERB
eurjchem-1748	206	30	an	an	DET
eurjchem-1748	206	31	important	important	ADJ
eurjchem-1748	206	32	other	other	ADJ
eurjchem-1748	206	33	interaction	interaction	NOUN
eurjchem-1748	206	34	with	with	ADP
eurjchem-1748	206	35	tyr235	tyr235	PROPN
eurjchem-1748	206	36	(	(	PUNCT
eurjchem-1748	206	37	centroid	centroid	NOUN
eurjchem-1748	206	38	interaction	interaction	NOUN
eurjchem-1748	206	39	)	)	PUNCT
eurjchem-1748	206	40	.	.	PUNCT
eurjchem-1748	207	1	molecules	molecule	NOUN
eurjchem-1748	207	2	16	16	NUM
eurjchem-1748	207	3	,	,	PUNCT
eurjchem-1748	207	4	13	13	NUM
eurjchem-1748	207	5	and	and	CCONJ
eurjchem-1748	207	6	8	8	NUM
eurjchem-1748	207	7	shown	show	VERB
eurjchem-1748	207	8	good	good	ADJ
eurjchem-1748	207	9	binding	bind	VERB
eurjchem-1748	207	10	affinity	affinity	NOUN
eurjchem-1748	207	11	towards	towards	ADP
eurjchem-1748	207	12	α	α	NOUN
eurjchem-1748	207	13	-	-	PUNCT
eurjchem-1748	207	14	glucosidase	glucosidase	ADJ
eurjchem-1748	207	15	active	active	ADJ
eurjchem-1748	207	16	site	site	NOUN
eurjchem-1748	207	17	,	,	PUNCT
eurjchem-1748	207	18	but	but	CCONJ
eurjchem-1748	207	19	molecule	molecule	NOUN
eurjchem-1748	207	20	16	16	NUM
eurjchem-1748	207	21	top	top	NOUN
eurjchem-1748	207	22	scored	score	VERB
eurjchem-1748	207	23	one	one	NUM
eurjchem-1748	207	24	according	accord	VERB
eurjchem-1748	207	25	to	to	ADP
eurjchem-1748	207	26	the	the	DET
eurjchem-1748	207	27	analysis	analysis	NOUN
eurjchem-1748	207	28	.	.	PUNCT
eurjchem-1748	208	1	based	base	VERB
eurjchem-1748	208	2	on	on	ADP
eurjchem-1748	208	3	their	their	PRON
eurjchem-1748	208	4	in	in	ADP
eurjchem-1748	208	5	-	-	PUNCT
eurjchem-1748	208	6	silico	silico	NOUN
eurjchem-1748	208	7	property	property	NOUN
eurjchem-1748	208	8	analysis	analysis	NOUN
eurjchem-1748	208	9	we	we	PRON
eurjchem-1748	208	10	considered	consider	VERB
eurjchem-1748	208	11	for	for	ADP
eurjchem-1748	208	12	synthesis	synthesis	NOUN
eurjchem-1748	208	13	.	.	PUNCT
eurjchem-1748	209	1	from	from	ADP
eurjchem-1748	209	2	our	our	PRON
eurjchem-1748	209	3	previous	previous	ADJ
eurjchem-1748	209	4	work	work	NOUN
eurjchem-1748	209	5	the	the	DET
eurjchem-1748	209	6	c-4	c-4	NOUN
eurjchem-1748	209	7	and	and	CCONJ
eurjchem-1748	209	8	c-6	c-6	NOUN
eurjchem-1748	209	9	position	position	NOUN
eurjchem-1748	209	10	of	of	ADP
eurjchem-1748	209	11	the	the	DET
eurjchem-1748	209	12	reported	report	VERB
eurjchem-1748	209	13	quinazoline	quinazoline	NOUN
eurjchem-1748	209	14	moiety	moiety	NOUN
eurjchem-1748	209	15	was	be	AUX
eurjchem-1748	209	16	well	well	ADV
eurjchem-1748	209	17	explored	explore	VERB
eurjchem-1748	209	18	for	for	ADP
eurjchem-1748	209	19	creating	create	VERB
eurjchem-1748	209	20	sar	sar	NOUN
eurjchem-1748	209	21	of	of	ADP
eurjchem-1748	209	22	many	many	ADJ
eurjchem-1748	209	23	new	new	ADJ
eurjchem-1748	209	24	chemical	chemical	NOUN
eurjchem-1748	209	25	entities	entity	NOUN
eurjchem-1748	210	1	[	[	X
eurjchem-1748	210	2	23,26	23,26	NOUN
eurjchem-1748	210	3	]	]	X
eurjchem-1748	210	4	,	,	PUNCT
eurjchem-1748	210	5	here	here	ADV
eurjchem-1748	210	6	this	this	DET
eurjchem-1748	210	7	work	work	NOUN
eurjchem-1748	210	8	is	be	AUX
eurjchem-1748	210	9	an	an	DET
eurjchem-1748	210	10	extension	extension	NOUN
eurjchem-1748	210	11	of	of	ADP
eurjchem-1748	210	12	the	the	DET
eurjchem-1748	210	13	previous	previous	ADJ
eurjchem-1748	210	14	report	report	NOUN
eurjchem-1748	210	15	.	.	PUNCT
eurjchem-1748	211	1	we	we	PRON
eurjchem-1748	211	2	designed	design	VERB
eurjchem-1748	211	3	,	,	PUNCT
eurjchem-1748	211	4	few	few	ADJ
eurjchem-1748	211	5	more	more	ADJ
eurjchem-1748	211	6	novel	novel	ADJ
eurjchem-1748	211	7	quinazoline	quinazoline	NOUN
eurjchem-1748	211	8	based	base	VERB
eurjchem-1748	211	9	derivatives	derivative	NOUN
eurjchem-1748	211	10	by	by	ADP
eurjchem-1748	211	11	exploring	explore	VERB
eurjchem-1748	211	12	the	the	DET
eurjchem-1748	211	13	central	central	ADJ
eurjchem-1748	211	14	moieties	moiety	NOUN
eurjchem-1748	211	15	at	at	ADP
eurjchem-1748	211	16	c-7	c-7	NOUN
eurjchem-1748	211	17	position	position	NOUN
eurjchem-1748	211	18	the	the	DET
eurjchem-1748	211	19	first	first	ADJ
eurjchem-1748	211	20	biochemical	biochemical	ADJ
eurjchem-1748	211	21	screening	screening	NOUN
eurjchem-1748	211	22	yielded	yield	VERB
eurjchem-1748	211	23	a	a	DET
eurjchem-1748	211	24	considerable	considerable	ADJ
eurjchem-1748	211	25	activity	activity	NOUN
eurjchem-1748	211	26	against	against	ADP
eurjchem-1748	211	27	α	α	NOUN
eurjchem-1748	211	28	-	-	PUNCT
eurjchem-1748	211	29	glucosidase	glucosidase	ADJ
eurjchem-1748	211	30	function	function	NOUN
eurjchem-1748	211	31	inhibition	inhibition	NOUN
eurjchem-1748	211	32	i.e.	i.e.	X
eurjchem-1748	211	33	ic50	ic50	PROPN
eurjchem-1748	211	34	≤	≤	NUM
eurjchem-1748	211	35	1.8	1.8	NUM
eurjchem-1748	211	36	um	um	INTJ
eurjchem-1748	211	37	,	,	PUNCT
eurjchem-1748	211	38	after	after	ADP
eurjchem-1748	211	39	that	that	PRON
eurjchem-1748	211	40	we	we	PRON
eurjchem-1748	211	41	selected	select	VERB
eurjchem-1748	211	42	a	a	DET
eurjchem-1748	211	43	specific	specific	ADJ
eurjchem-1748	211	44	molecular	molecular	ADJ
eurjchem-1748	211	45	frame	frame	NOUN
eurjchem-1748	211	46	of	of	ADP
eurjchem-1748	211	47	quinazoline	quinazoline	NOUN
eurjchem-1748	211	48	core	core	NOUN
eurjchem-1748	211	49	2018	2018	NUM
eurjchem-1748	211	50	–	–	PUNCT
eurjchem-1748	211	51	european	european	ADJ
eurjchem-1748	211	52	journal	journal	NOUN
eurjchem-1748	211	53	of	of	ADP
eurjchem-1748	211	54	chemistry	chemistry	NOUN
eurjchem-1748	211	55	–	–	PUNCT
eurjchem-1748	211	56	cc	cc	NOUN
eurjchem-1748	211	57	by	by	ADP
eurjchem-1748	211	58	nc	nc	PROPN
eurjchem-1748	211	59	–	–	PUNCT
eurjchem-1748	211	60	doi	doi	PROPN
eurjchem-1748	211	61	:	:	PUNCT
eurjchem-1748	211	62	10.5155	10.5155	NUM
eurjchem-1748	211	63	/	/	SYM
eurjchem-1748	211	64	eurjchem.9.4.322	eurjchem.9.4.322	PROPN
eurjchem-1748	211	65	-	-	PUNCT
eurjchem-1748	211	66	330.1748	330.1748	NUM
eurjchem-1748	211	67	ankireddy	ankireddy	NOUN
eurjchem-1748	211	68	et	et	PROPN
eurjchem-1748	211	69	al	al	PROPN
eurjchem-1748	211	70	.	.	PUNCT
eurjchem-1748	211	71	/	/	SYM
eurjchem-1748	211	72	european	european	PROPN
eurjchem-1748	211	73	journal	journal	PROPN
eurjchem-1748	211	74	of	of	ADP
eurjchem-1748	211	75	chemistry	chemistry	NOUN
eurjchem-1748	211	76	9	9	NUM
eurjchem-1748	211	77	(	(	PUNCT
eurjchem-1748	211	78	4	4	NUM
eurjchem-1748	211	79	)	)	PUNCT
eurjchem-1748	211	80	(	(	PUNCT
eurjchem-1748	211	81	2018	2018	NUM
eurjchem-1748	211	82	)	)	PUNCT
eurjchem-1748	211	83	322	322	NUM
eurjchem-1748	211	84	-	-	SYM
eurjchem-1748	211	85	330	330	NUM
eurjchem-1748	211	86	329	329	NUM
eurjchem-1748	211	87	table	table	NOUN
eurjchem-1748	211	88	3	3	NUM
eurjchem-1748	211	89	.	.	PUNCT
eurjchem-1748	211	90	in	in	ADP
eurjchem-1748	211	91	-	-	PUNCT
eurjchem-1748	211	92	vivo	vivo	NOUN
eurjchem-1748	211	93	activity	activity	NOUN
eurjchem-1748	211	94	of	of	ADP
eurjchem-1748	211	95	selective	selective	ADJ
eurjchem-1748	211	96	molecules	molecule	NOUN
eurjchem-1748	211	97	.	.	PUNCT
eurjchem-1748	212	1	treatment	treatment	NOUN
eurjchem-1748	212	2	blood	blood	NOUN
eurjchem-1748	212	3	glucose	glucose	NOUN
eurjchem-1748	212	4	levels	level	NOUN
eurjchem-1748	212	5	(	(	PUNCT
eurjchem-1748	212	6	mg	mg	PROPN
eurjchem-1748	212	7	/	/	SYM
eurjchem-1748	212	8	dl	dl	NOUN
eurjchem-1748	212	9	)	)	PUNCT
eurjchem-1748	212	10	at	at	ADP
eurjchem-1748	212	11	various	various	ADJ
eurjchem-1748	212	12	intervals	interval	NOUN
eurjchem-1748	212	13	(	(	PUNCT
eurjchem-1748	212	14	days	day	NOUN
eurjchem-1748	212	15	)	)	PUNCT
eurjchem-1748	212	16	&	&	CCONJ
eurjchem-1748	212	17	1	1	NUM
eurjchem-1748	212	18	7	7	NUM
eurjchem-1748	212	19	14	14	NUM
eurjchem-1748	212	20	21	21	NUM
eurjchem-1748	212	21	control	control	NOUN
eurjchem-1748	212	22	71.5±4.3	71.5±4.3	NUM
eurjchem-1748	212	23	b	b	NOUN
eurjchem-1748	212	24	#	#	NOUN
eurjchem-1748	212	25	68.2±6.1	68.2±6.1	NUM
eurjchem-1748	212	26	b	b	NOUN
eurjchem-1748	212	27	#	#	NOUN
eurjchem-1748	212	28	66.1±4.2	66.1±4.2	NUM
eurjchem-1748	212	29	b	b	NOUN
eurjchem-1748	212	30	#	#	NOUN
eurjchem-1748	212	31	72.0±6.8	72.0±6.8	NUM
eurjchem-1748	212	32	b	b	NUM
eurjchem-1748	212	33	#	#	NOUN
eurjchem-1748	212	34	negative	negative	ADJ
eurjchem-1748	212	35	control	control	NOUN
eurjchem-1748	212	36	311.0±6.9	311.0±6.9	ADJ
eurjchem-1748	212	37	304.6±10.7	304.6±10.7	NUM
eurjchem-1748	212	38	307.3±10.5	307.3±10.5	NUM
eurjchem-1748	212	39	316.6±9.6	316.6±9.6	NUM
eurjchem-1748	212	40	8	8	NUM
eurjchem-1748	212	41	316.3±11.8	316.3±11.8	NUM
eurjchem-1748	212	42	bns	bns	NOUN
eurjchem-1748	212	43	224.4±14.3	224.4±14.3	NUM
eurjchem-1748	212	44	a**b	a**b	ADJ
eurjchem-1748	212	45	*	*	NUM
eurjchem-1748	212	46	*	*	NOUN
eurjchem-1748	212	47	178.4±9.3	178.4±9.3	NUM
eurjchem-1748	212	48	a#b	a#b	PROPN
eurjchem-1748	212	49	#	#	NOUN
eurjchem-1748	212	50	166.1±8.7	166.1±8.7	NUM
eurjchem-1748	212	51	a**b	a**b	ADJ
eurjchem-1748	212	52	#	#	NOUN
eurjchem-1748	212	53	13	13	NUM
eurjchem-1748	212	54	281.4±7.3	281.4±7.3	NOUN
eurjchem-1748	212	55	bns	bns	NOUN
eurjchem-1748	212	56	227.2±8.1	227.2±8.1	PROPN
eurjchem-1748	212	57	a*b	a*b	PROPN
eurjchem-1748	212	58	*	*	PROPN
eurjchem-1748	212	59	*	*	PROPN
eurjchem-1748	212	60	187.6±6.5	187.6±6.5	NUM
eurjchem-1748	212	61	a**b	a**b	ADJ
eurjchem-1748	212	62	#	#	NOUN
eurjchem-1748	212	63	133.5±5.5	133.5±5.5	NUM
eurjchem-1748	213	1	a#b	a#b	ADJ
eurjchem-1748	213	2	#	#	NOUN
eurjchem-1748	213	3	14	14	NUM
eurjchem-1748	213	4	301.8±14.1	301.8±14.1	NUM
eurjchem-1748	213	5	bns	bns	NOUN
eurjchem-1748	213	6	213.1±9.6	213.1±9.6	NUM
eurjchem-1748	213	7	a**b	a**b	ADJ
eurjchem-1748	213	8	*	*	PUNCT
eurjchem-1748	213	9	*	*	NOUN
eurjchem-1748	213	10	212.8±11.1	212.8±11.1	NUM
eurjchem-1748	213	11	a**b	a**b	ADJ
eurjchem-1748	213	12	*	*	PROPN
eurjchem-1748	213	13	*	*	NOUN
eurjchem-1748	213	14	191.0±6.4	191.0±6.4	NUM
eurjchem-1748	213	15	a**b	a**b	ADJ
eurjchem-1748	213	16	*	*	PROPN
eurjchem-1748	213	17	*	*	PROPN
eurjchem-1748	213	18	22	22	NUM
eurjchem-1748	213	19	317.4±12.7	317.4±12.7	NUM
eurjchem-1748	213	20	bns	bns	NOUN
eurjchem-1748	213	21	221.3±13.2	221.3±13.2	PROPN
eurjchem-1748	213	22	a**b	a**b	NOUN
eurjchem-1748	213	23	*	*	NOUN
eurjchem-1748	213	24	*	*	PUNCT
eurjchem-1748	213	25	153.5±6.3	153.5±6.3	NUM
eurjchem-1748	214	1	a#b	a#b	PROPN
eurjchem-1748	214	2	#	#	NOUN
eurjchem-1748	214	3	128.5±4.5	128.5±4.5	NUM
eurjchem-1748	214	4	a#b	a#b	PROPN
eurjchem-1748	214	5	#	#	NOUN
eurjchem-1748	214	6	27	27	NUM
eurjchem-1748	214	7	298.4±14.3	298.4±14.3	NUM
eurjchem-1748	214	8	bns	bns	NOUN
eurjchem-1748	214	9	244.6±11.3	244.6±11.3	ADJ
eurjchem-1748	214	10	a*b	a*b	PROPN
eurjchem-1748	214	11	*	*	PROPN
eurjchem-1748	214	12	171.7±6.7	171.7±6.7	NUM
eurjchem-1748	214	13	a**b	a**b	ADJ
eurjchem-1748	214	14	#	#	NOUN
eurjchem-1748	214	15	152.3±5.4	152.3±5.4	NUM
eurjchem-1748	214	16	a#b	a#b	PROPN
eurjchem-1748	214	17	#	#	NOUN
eurjchem-1748	214	18	pio	pio	NOUN
eurjchem-1748	214	19	2.7	2.7	NUM
eurjchem-1748	214	20	mg	mg	PROPN
eurjchem-1748	214	21	/	/	SYM
eurjchem-1748	214	22	kg	kg	PROPN
eurjchem-1748	214	23	304.2±12.1bns	304.2±12.1bns	NUM
eurjchem-1748	214	24	198.3±6.8	198.3±6.8	NUM
eurjchem-1748	215	1	a#b	a#b	VERB
eurjchem-1748	215	2	#	#	NOUN
eurjchem-1748	215	3	132.4±8.0	132.4±8.0	NUM
eurjchem-1748	216	1	a#b	a#b	PROPN
eurjchem-1748	216	2	#	#	NOUN
eurjchem-1748	216	3	108.4±7.5	108.4±7.5	NUM
eurjchem-1748	216	4	a#b	a#b	PROPN
eurjchem-1748	216	5	#	#	NOUN
eurjchem-1748	216	6	&	&	CCONJ
eurjchem-1748	216	7	data	datum	NOUN
eurjchem-1748	216	8	represents	represent	VERB
eurjchem-1748	216	9	mean±sem	mean±sem	PROPN
eurjchem-1748	216	10	of	of	ADP
eurjchem-1748	216	11	blood	blood	NOUN
eurjchem-1748	216	12	glucose	glucose	NOUN
eurjchem-1748	216	13	levels	level	NOUN
eurjchem-1748	216	14	in	in	ADP
eurjchem-1748	216	15	rats	rat	NOUN
eurjchem-1748	216	16	treated	treat	VERB
eurjchem-1748	216	17	with	with	ADP
eurjchem-1748	216	18	test	test	NOUN
eurjchem-1748	216	19	compounds	compound	NOUN
eurjchem-1748	216	20	for	for	ADP
eurjchem-1748	216	21	21	21	NUM
eurjchem-1748	216	22	days	day	NOUN
eurjchem-1748	216	23	.	.	PUNCT
eurjchem-1748	217	1	a	a	PRON
eurjchem-1748	217	2	represents	represent	VERB
eurjchem-1748	217	3	comparison	comparison	NOUN
eurjchem-1748	217	4	of	of	ADP
eurjchem-1748	217	5	blood	blood	NOUN
eurjchem-1748	217	6	glucose	glucose	NOUN
eurjchem-1748	217	7	levels	level	NOUN
eurjchem-1748	217	8	on	on	ADP
eurjchem-1748	217	9	day	day	NOUN
eurjchem-1748	217	10	7	7	NUM
eurjchem-1748	217	11	,	,	PUNCT
eurjchem-1748	217	12	14	14	NUM
eurjchem-1748	217	13	and	and	CCONJ
eurjchem-1748	217	14	21	21	NUM
eurjchem-1748	217	15	with	with	ADP
eurjchem-1748	217	16	that	that	PRON
eurjchem-1748	217	17	of	of	ADP
eurjchem-1748	217	18	day	day	NOUN
eurjchem-1748	217	19	1	1	NUM
eurjchem-1748	217	20	.	.	X
eurjchem-1748	217	21	b	b	X
eurjchem-1748	217	22	blood	blood	NOUN
eurjchem-1748	217	23	glucose	glucose	NOUN
eurjchem-1748	217	24	levels	level	NOUN
eurjchem-1748	217	25	of	of	ADP
eurjchem-1748	217	26	all	all	DET
eurjchem-1748	217	27	the	the	DET
eurjchem-1748	217	28	groups	group	NOUN
eurjchem-1748	217	29	(	(	PUNCT
eurjchem-1748	217	30	n	n	NOUN
eurjchem-1748	217	31	=	=	SYM
eurjchem-1748	217	32	6	6	NUM
eurjchem-1748	217	33	)	)	PUNCT
eurjchem-1748	217	34	compared	compare	VERB
eurjchem-1748	217	35	with	with	ADP
eurjchem-1748	217	36	that	that	PRON
eurjchem-1748	217	37	of	of	ADP
eurjchem-1748	217	38	negative	negative	ADJ
eurjchem-1748	217	39	control	control	NOUN
eurjchem-1748	217	40	group	group	NOUN
eurjchem-1748	217	41	using	use	VERB
eurjchem-1748	217	42	one	one	NUM
eurjchem-1748	217	43	way	way	NOUN
eurjchem-1748	217	44	anova	anova	PROPN
eurjchem-1748	217	45	followed	follow	VERB
eurjchem-1748	217	46	by	by	ADP
eurjchem-1748	217	47	dunnett	dunnett	PROPN
eurjchem-1748	217	48	’s	’s	PART
eurjchem-1748	217	49	test	test	NOUN
eurjchem-1748	218	1	[	[	X
eurjchem-1748	218	2	30	30	NUM
eurjchem-1748	218	3	]	]	SYM
eurjchem-1748	218	4	.	.	PUNCT
eurjchem-1748	218	5	0	0	NUM
eurjchem-1748	218	6	50	50	NUM
eurjchem-1748	218	7	100	100	NUM
eurjchem-1748	218	8	150	150	NUM
eurjchem-1748	218	9	200	200	NUM
eurjchem-1748	218	10	27	27	NUM
eurjchem-1748	218	11	26	26	NUM
eurjchem-1748	218	12	25	25	NUM
eurjchem-1748	218	13	22	22	NUM
eurjchem-1748	218	14	16	16	NUM
eurjchem-1748	218	15	14	14	NUM
eurjchem-1748	218	16	13	13	NUM
eurjchem-1748	218	17	8	8	NUM
eurjchem-1748	218	18	%	%	NOUN
eurjchem-1748	218	19	of	of	ADP
eurjchem-1748	218	20	α	α	NOUN
eurjchem-1748	218	21	-	-	PUNCT
eurjchem-1748	218	22	glucosidase	glucosidase	ADJ
eurjchem-1748	218	23	inhibition	inhibition	NOUN
eurjchem-1748	218	24	c	c	NOUN
eurjchem-1748	218	25	om	om	PROPN
eurjchem-1748	218	26	po	po	PROPN
eurjchem-1748	218	27	un	un	PROPN
eurjchem-1748	218	28	ds	ds	PROPN
eurjchem-1748	218	29	20	20	NUM
eurjchem-1748	218	30	µg	µg	NOUN
eurjchem-1748	218	31	/	/	SYM
eurjchem-1748	218	32	ml	ml	NOUN
eurjchem-1748	218	33	40	40	NUM
eurjchem-1748	218	34	µg	µg	NOUN
eurjchem-1748	218	35	/	/	SYM
eurjchem-1748	218	36	ml	ml	PROPN
eurjchem-1748	218	37	60	60	NUM
eurjchem-1748	218	38	µg	µg	NOUN
eurjchem-1748	218	39	/	/	SYM
eurjchem-1748	218	40	ml	ml	NUM
eurjchem-1748	218	41	80	80	NUM
eurjchem-1748	218	42	µg	µg	NOUN
eurjchem-1748	218	43	/	/	SYM
eurjchem-1748	218	44	ml	ml	NOUN
eurjchem-1748	218	45	100	100	NUM
eurjchem-1748	218	46	µg	µg	ADJ
eurjchem-1748	218	47	/	/	SYM
eurjchem-1748	218	48	ml	ml	NOUN
eurjchem-1748	218	49	figure	figure	NOUN
eurjchem-1748	218	50	5	5	NUM
eurjchem-1748	218	51	.	.	PUNCT
eurjchem-1748	219	1	the	the	DET
eurjchem-1748	219	2	effect	effect	NOUN
eurjchem-1748	219	3	of	of	ADP
eurjchem-1748	219	4	inhibitor	inhibitor	NOUN
eurjchem-1748	219	5	dosage	dosage	NOUN
eurjchem-1748	219	6	on	on	ADP
eurjchem-1748	219	7	the	the	DET
eurjchem-1748	219	8	response	response	NOUN
eurjchem-1748	219	9	of	of	ADP
eurjchem-1748	219	10	α	α	NOUN
eurjchem-1748	219	11	-	-	NOUN
eurjchem-1748	219	12	glucosidase	glucosidase	ADJ
eurjchem-1748	219	13	(	(	PUNCT
eurjchem-1748	219	14	1	1	NUM
eurjchem-1748	219	15	mm	mm	NOUN
eurjchem-1748	219	16	)	)	PUNCT
eurjchem-1748	219	17	inhibition	inhibition	NOUN
eurjchem-1748	219	18	[	[	X
eurjchem-1748	219	19	27	27	NUM
eurjchem-1748	219	20	]	]	PUNCT
eurjchem-1748	219	21	.	.	PUNCT
eurjchem-1748	220	1	moiety	moiety	NOUN
eurjchem-1748	221	1	and	and	CCONJ
eurjchem-1748	221	2	we	we	PRON
eurjchem-1748	221	3	prepared	prepare	VERB
eurjchem-1748	221	4	an	an	DET
eurjchem-1748	221	5	sar	sar	NOUN
eurjchem-1748	221	6	which	which	PRON
eurjchem-1748	221	7	finally	finally	ADV
eurjchem-1748	221	8	resulted	result	VERB
eurjchem-1748	221	9	in	in	ADP
eurjchem-1748	221	10	significant	significant	ADJ
eurjchem-1748	221	11	activity	activity	NOUN
eurjchem-1748	221	12	of	of	ADP
eurjchem-1748	221	13	the	the	DET
eurjchem-1748	221	14	synthesized	synthesize	VERB
eurjchem-1748	221	15	molecules	molecule	NOUN
eurjchem-1748	221	16	.	.	PUNCT
eurjchem-1748	222	1	by	by	ADP
eurjchem-1748	222	2	correctness	correctness	NOUN
eurjchem-1748	222	3	of	of	ADP
eurjchem-1748	222	4	holding	hold	VERB
eurjchem-1748	222	5	qualified	qualified	ADJ
eurjchem-1748	222	6	drug	drug	NOUN
eurjchem-1748	222	7	-	-	PUNCT
eurjchem-1748	222	8	like	like	ADJ
eurjchem-1748	222	9	properties	property	NOUN
eurjchem-1748	222	10	,	,	PUNCT
eurjchem-1748	222	11	each	each	DET
eurjchem-1748	222	12	designed	design	VERB
eurjchem-1748	222	13	chemical	chemical	NOUN
eurjchem-1748	222	14	entity	entity	NOUN
eurjchem-1748	222	15	novel	novel	NOUN
eurjchem-1748	222	16	chemical	chemical	NOUN
eurjchem-1748	222	17	space	space	NOUN
eurjchem-1748	222	18	and	and	CCONJ
eurjchem-1748	222	19	based	base	VERB
eurjchem-1748	222	20	on	on	ADP
eurjchem-1748	222	21	this	this	PRON
eurjchem-1748	222	22	through	through	ADP
eurjchem-1748	222	23	analysis	analysis	NOUN
eurjchem-1748	222	24	,	,	PUNCT
eurjchem-1748	222	25	we	we	PRON
eurjchem-1748	222	26	prioritized	prioritize	VERB
eurjchem-1748	222	27	the	the	DET
eurjchem-1748	222	28	molecules	molecule	NOUN
eurjchem-1748	222	29	.	.	PUNCT
eurjchem-1748	223	1	the	the	DET
eurjchem-1748	223	2	designed	design	VERB
eurjchem-1748	223	3	novel	novel	NOUN
eurjchem-1748	223	4	quinazoline	quinazoline	NOUN
eurjchem-1748	223	5	based	base	VERB
eurjchem-1748	223	6	derivatives	derivative	NOUN
eurjchem-1748	223	7	which	which	PRON
eurjchem-1748	223	8	is	be	AUX
eurjchem-1748	223	9	modified	modify	VERB
eurjchem-1748	223	10	at	at	ADP
eurjchem-1748	223	11	c-7	c-7	NOUN
eurjchem-1748	223	12	position	position	NOUN
eurjchem-1748	223	13	and	and	CCONJ
eurjchem-1748	223	14	its	its	PRON
eurjchem-1748	223	15	final	final	ADJ
eurjchem-1748	223	16	biochemical	biochemical	ADJ
eurjchem-1748	223	17	essay	essay	NOUN
eurjchem-1748	223	18	yielded	yield	VERB
eurjchem-1748	223	19	eight	eight	NUM
eurjchem-1748	223	20	molecules	molecule	NOUN
eurjchem-1748	223	21	with	with	ADP
eurjchem-1748	223	22	considerable	considerable	ADJ
eurjchem-1748	223	23	activity	activity	NOUN
eurjchem-1748	223	24	(	(	PUNCT
eurjchem-1748	223	25	table	table	NOUN
eurjchem-1748	223	26	1	1	NUM
eurjchem-1748	223	27	)	)	PUNCT
eurjchem-1748	223	28	i.e.	i.e.	X
eurjchem-1748	223	29	ic50	ic50	PROPN
eurjchem-1748	223	30	=	=	SYM
eurjchem-1748	223	31	1.122	1.122	NUM
eurjchem-1748	223	32	,	,	PUNCT
eurjchem-1748	223	33	1.218	1.218	NUM
eurjchem-1748	223	34	,	,	PUNCT
eurjchem-1748	223	35	1.299	1.299	NUM
eurjchem-1748	223	36	,	,	PUNCT
eurjchem-1748	223	37	1.323	1.323	NUM
eurjchem-1748	223	38	,	,	PUNCT
eurjchem-1748	223	39	1.310	1.310	NUM
eurjchem-1748	223	40	,	,	PUNCT
eurjchem-1748	223	41	2.140	2.140	NUM
eurjchem-1748	223	42	,	,	PUNCT
eurjchem-1748	223	43	2.349	2.349	NUM
eurjchem-1748	223	44	and	and	CCONJ
eurjchem-1748	223	45	2.227	2.227	NUM
eurjchem-1748	223	46	um	um	INTJ
eurjchem-1748	223	47	,	,	PUNCT
eurjchem-1748	223	48	molecule	molecule	NOUN
eurjchem-1748	223	49	14	14	NUM
eurjchem-1748	223	50	,	,	PUNCT
eurjchem-1748	223	51	16	16	NUM
eurjchem-1748	223	52	,	,	PUNCT
eurjchem-1748	223	53	27	27	NUM
eurjchem-1748	223	54	,	,	PUNCT
eurjchem-1748	223	55	8	8	NUM
eurjchem-1748	223	56	,	,	PUNCT
eurjchem-1748	223	57	13	13	NUM
eurjchem-1748	223	58	,	,	PUNCT
eurjchem-1748	223	59	25	25	NUM
eurjchem-1748	223	60	,	,	PUNCT
eurjchem-1748	223	61	22	22	NUM
eurjchem-1748	223	62	and	and	CCONJ
eurjchem-1748	223	63	26	26	NUM
eurjchem-1748	223	64	,	,	PUNCT
eurjchem-1748	223	65	respectively	respectively	ADV
eurjchem-1748	223	66	.	.	PUNCT
eurjchem-1748	224	1	the	the	DET
eurjchem-1748	224	2	detailed	detail	VERB
eurjchem-1748	224	3	adme	adme	NOUN
eurjchem-1748	224	4	properties	property	NOUN
eurjchem-1748	224	5	tabulated	tabulate	VERB
eurjchem-1748	224	6	for	for	ADP
eurjchem-1748	224	7	all	all	DET
eurjchem-1748	224	8	reported	report	VERB
eurjchem-1748	224	9	molecules	molecule	NOUN
eurjchem-1748	224	10	in	in	ADP
eurjchem-1748	224	11	table	table	NOUN
eurjchem-1748	224	12	2	2	NUM
eurjchem-1748	224	13	.	.	NOUN
eurjchem-1748	224	14	3.2	3.2	NUM
eurjchem-1748	224	15	.	.	PUNCT
eurjchem-1748	225	1	biochemical	biochemical	ADJ
eurjchem-1748	225	2	assay	assay	NOUN
eurjchem-1748	225	3	of	of	ADP
eurjchem-1748	225	4	the	the	DET
eurjchem-1748	225	5	synthesized	synthesize	VERB
eurjchem-1748	225	6	compounds	compound	NOUN
eurjchem-1748	225	7	(	(	PUNCT
eurjchem-1748	225	8	invitro	invitro	ADJ
eurjchem-1748	225	9	study	study	NOUN
eurjchem-1748	225	10	)	)	PUNCT
eurjchem-1748	225	11	in	in	ADP
eurjchem-1748	225	12	the	the	DET
eurjchem-1748	225	13	current	current	ADJ
eurjchem-1748	225	14	study	study	NOUN
eurjchem-1748	225	15	,	,	PUNCT
eurjchem-1748	225	16	we	we	PRON
eurjchem-1748	225	17	have	have	AUX
eurjchem-1748	225	18	selected	select	VERB
eurjchem-1748	225	19	the	the	DET
eurjchem-1748	225	20	quinazolin-7chloro	quinazolin-7chloro	PROPN
eurjchem-1748	225	21	scaffold	scaffold	NOUN
eurjchem-1748	225	22	for	for	ADP
eurjchem-1748	225	23	the	the	DET
eurjchem-1748	225	24	generation	generation	NOUN
eurjchem-1748	225	25	of	of	ADP
eurjchem-1748	225	26	a	a	DET
eurjchem-1748	225	27	focused	focused	ADJ
eurjchem-1748	225	28	library	library	NOUN
eurjchem-1748	225	29	to	to	PART
eurjchem-1748	225	30	identify	identify	VERB
eurjchem-1748	225	31	potential	potential	ADJ
eurjchem-1748	225	32	inhibitors	inhibitor	NOUN
eurjchem-1748	225	33	of	of	ADP
eurjchem-1748	225	34	α	α	NOUN
eurjchem-1748	225	35	-	-	PUNCT
eurjchem-1748	225	36	glucosidase	glucosidase	NOUN
eurjchem-1748	225	37	.	.	PUNCT
eurjchem-1748	226	1	compound	compound	NOUN
eurjchem-1748	226	2	8	8	NUM
eurjchem-1748	226	3	,	,	PUNCT
eurjchem-1748	226	4	with	with	ADP
eurjchem-1748	226	5	phenyl	phenyl	NOUN
eurjchem-1748	226	6	substitution	substitution	NOUN
eurjchem-1748	226	7	at	at	ADP
eurjchem-1748	226	8	7th	7th	ADJ
eurjchem-1748	226	9	position	position	NOUN
eurjchem-1748	226	10	that	that	PRON
eurjchem-1748	226	11	is	be	AUX
eurjchem-1748	226	12	2	2	NUM
eurjchem-1748	226	13	-	-	PUNCT
eurjchem-1748	226	14	morpholino-7phenyl	morpholino-7phenyl	NOUN
eurjchem-1748	226	15	-	-	PUNCT
eurjchem-1748	226	16	n-(pyridin-2	n-(pyridin-2	NOUN
eurjchem-1748	226	17	-	-	PUNCT
eurjchem-1748	226	18	ylmethyl	ylmethyl	NOUN
eurjchem-1748	226	19	)	)	PUNCT
eurjchem-1748	226	20	quinazolin-4	quinazolin-4	NOUN
eurjchem-1748	226	21	-	-	PUNCT
eurjchem-1748	226	22	amine	amine	NOUN
eurjchem-1748	226	23	showed	show	VERB
eurjchem-1748	226	24	an	an	DET
eurjchem-1748	226	25	ic50	ic50	PROPN
eurjchem-1748	226	26	value	value	NOUN
eurjchem-1748	226	27	of	of	ADP
eurjchem-1748	226	28	1.323	1.323	NUM
eurjchem-1748	226	29	µm	µm	NOUN
eurjchem-1748	226	30	.	.	PUNCT
eurjchem-1748	227	1	the	the	DET
eurjchem-1748	227	2	4	4	NUM
eurjchem-1748	227	3	-	-	PUNCT
eurjchem-1748	227	4	bi	bi	ADJ
eurjchem-1748	227	5	-	-	ADJ
eurjchem-1748	227	6	phenyl	phenyl	ADJ
eurjchem-1748	227	7	substituted	substitute	VERB
eurjchem-1748	227	8	compound	compound	NOUN
eurjchem-1748	227	9	13	13	NUM
eurjchem-1748	227	10	showed	show	VERB
eurjchem-1748	227	11	ic50	ic50	PROPN
eurjchem-1748	227	12	value	value	NOUN
eurjchem-1748	227	13	of	of	ADP
eurjchem-1748	227	14	1.310	1.310	NUM
eurjchem-1748	227	15	µm	µm	ADP
eurjchem-1748	227	16	and	and	CCONJ
eurjchem-1748	227	17	3	3	NUM
eurjchem-1748	227	18	-	-	PUNCT
eurjchem-1748	227	19	methoxy	methoxy	ADJ
eurjchem-1748	227	20	-	-	PUNCT
eurjchem-1748	227	21	phenyl	phenyl	NOUN
eurjchem-1748	227	22	substituted	substitute	VERB
eurjchem-1748	227	23	compound	compound	NOUN
eurjchem-1748	227	24	,	,	PUNCT
eurjchem-1748	227	25	14	14	NUM
eurjchem-1748	227	26	,	,	PUNCT
eurjchem-1748	227	27	showed	show	VERB
eurjchem-1748	227	28	ic50	ic50	PROPN
eurjchem-1748	227	29	value	value	NOUN
eurjchem-1748	227	30	of	of	ADP
eurjchem-1748	227	31	1.122	1.122	NUM
eurjchem-1748	227	32	µm	µm	NOUN
eurjchem-1748	227	33	.	.	PUNCT
eurjchem-1748	228	1	the	the	DET
eurjchem-1748	228	2	ic50	ic50	PROPN
eurjchem-1748	228	3	values	value	NOUN
eurjchem-1748	228	4	of	of	ADP
eurjchem-1748	228	5	six	six	NUM
eurjchem-1748	228	6	compounds	compound	NOUN
eurjchem-1748	228	7	16	16	NUM
eurjchem-1748	228	8	,	,	PUNCT
eurjchem-1748	228	9	22	22	NUM
eurjchem-1748	228	10	,	,	PUNCT
eurjchem-1748	228	11	25	25	NUM
eurjchem-1748	228	12	,	,	PUNCT
eurjchem-1748	228	13	26	26	NUM
eurjchem-1748	228	14	and	and	CCONJ
eurjchem-1748	228	15	27	27	NUM
eurjchem-1748	228	16	were	be	AUX
eurjchem-1748	228	17	1.218	1.218	NUM
eurjchem-1748	228	18	,	,	PUNCT
eurjchem-1748	228	19	2.349	2.349	NUM
eurjchem-1748	228	20	,	,	PUNCT
eurjchem-1748	228	21	2.140	2.140	NUM
eurjchem-1748	228	22	,	,	PUNCT
eurjchem-1748	228	23	2.227	2.227	NUM
eurjchem-1748	228	24	and	and	CCONJ
eurjchem-1748	228	25	1.299	1.299	NUM
eurjchem-1748	228	26	µm	µm	NOUN
eurjchem-1748	228	27	,	,	PUNCT
eurjchem-1748	228	28	respectively	respectively	ADV
eurjchem-1748	228	29	.	.	PUNCT
eurjchem-1748	229	1	the	the	DET
eurjchem-1748	229	2	reference	reference	NOUN
eurjchem-1748	229	3	compound	compound	NOUN
eurjchem-1748	229	4	,	,	PUNCT
eurjchem-1748	229	5	acarbose	acarbose	NOUN
eurjchem-1748	229	6	,	,	PUNCT
eurjchem-1748	229	7	ic50	ic50	PROPN
eurjchem-1748	229	8	value	value	NOUN
eurjchem-1748	229	9	is	be	AUX
eurjchem-1748	229	10	0.586	0.586	NUM
eurjchem-1748	229	11	µm	µm	NOUN
eurjchem-1748	229	12	in	in	ADP
eurjchem-1748	229	13	the	the	DET
eurjchem-1748	229	14	essay	essay	NOUN
eurjchem-1748	229	15	.	.	PUNCT
eurjchem-1748	230	1	the	the	DET
eurjchem-1748	230	2	eight	eight	NUM
eurjchem-1748	230	3	compounds	compound	NOUN
eurjchem-1748	230	4	shown	show	VERB
eurjchem-1748	230	5	similar	similar	ADJ
eurjchem-1748	230	6	inhibition	inhibition	NOUN
eurjchem-1748	230	7	compared	compare	VERB
eurjchem-1748	230	8	to	to	ADP
eurjchem-1748	230	9	reference	reference	NOUN
eurjchem-1748	230	10	compound	compound	NOUN
eurjchem-1748	230	11	,	,	PUNCT
eurjchem-1748	230	12	but	but	CCONJ
eurjchem-1748	230	13	unfortunately	unfortunately	ADV
eurjchem-1748	230	14	few	few	ADJ
eurjchem-1748	230	15	other	other	ADJ
eurjchem-1748	230	16	compounds	compound	NOUN
eurjchem-1748	230	17	did	do	AUX
eurjchem-1748	230	18	not	not	PART
eurjchem-1748	230	19	show	show	VERB
eurjchem-1748	230	20	any	any	DET
eurjchem-1748	230	21	activity	activity	NOUN
eurjchem-1748	230	22	against	against	ADP
eurjchem-1748	230	23	α	α	NOUN
eurjchem-1748	230	24	-	-	NOUN
eurjchem-1748	230	25	glucosidase	glucosidase	PROPN
eurjchem-1748	230	26	(	(	PUNCT
eurjchem-1748	230	27	compounds	compound	VERB
eurjchem-1748	230	28	9	9	NUM
eurjchem-1748	230	29	-	-	SYM
eurjchem-1748	230	30	12	12	NUM
eurjchem-1748	230	31	,	,	PUNCT
eurjchem-1748	230	32	15	15	NUM
eurjchem-1748	230	33	,	,	PUNCT
eurjchem-1748	230	34	17	17	NUM
eurjchem-1748	230	35	-	-	SYM
eurjchem-1748	230	36	21	21	NUM
eurjchem-1748	230	37	,	,	PUNCT
eurjchem-1748	230	38	23	23	NUM
eurjchem-1748	230	39	and	and	CCONJ
eurjchem-1748	230	40	24	24	NUM
eurjchem-1748	230	41	)	)	PUNCT
eurjchem-1748	230	42	(	(	PUNCT
eurjchem-1748	230	43	figure	figure	NOUN
eurjchem-1748	230	44	5	5	NUM
eurjchem-1748	230	45	)	)	PUNCT
eurjchem-1748	230	46	.	.	PUNCT
eurjchem-1748	231	1	3.3	3.3	NUM
eurjchem-1748	231	2	.	.	PUNCT
eurjchem-1748	232	1	in	in	ADP
eurjchem-1748	232	2	-	-	PUNCT
eurjchem-1748	232	3	vivo	vivo	NOUN
eurjchem-1748	232	4	study	study	NOUN
eurjchem-1748	232	5	oral	oral	ADJ
eurjchem-1748	232	6	glucose	glucose	NOUN
eurjchem-1748	232	7	tolerance	tolerance	NOUN
eurjchem-1748	232	8	test	test	NOUN
eurjchem-1748	232	9	on	on	ADP
eurjchem-1748	232	10	7th	7th	ADJ
eurjchem-1748	232	11	and	and	CCONJ
eurjchem-1748	232	12	12th	12th	ADJ
eurjchem-1748	232	13	week	week	NOUN
eurjchem-1748	232	14	had	have	AUX
eurjchem-1748	232	15	shown	show	VERB
eurjchem-1748	232	16	a	a	DET
eurjchem-1748	232	17	protective	protective	ADJ
eurjchem-1748	232	18	effect	effect	NOUN
eurjchem-1748	232	19	against	against	ADP
eurjchem-1748	232	20	increase	increase	NOUN
eurjchem-1748	232	21	in	in	ADP
eurjchem-1748	232	22	blood	blood	NOUN
eurjchem-1748	232	23	glucose	glucose	NOUN
eurjchem-1748	232	24	levels	level	NOUN
eurjchem-1748	232	25	in	in	ADP
eurjchem-1748	232	26	pre	pre	ADJ
eurjchem-1748	232	27	-	-	ADJ
eurjchem-1748	232	28	treated	treat	VERB
eurjchem-1748	232	29	groups	group	NOUN
eurjchem-1748	232	30	whereas	whereas	SCONJ
eurjchem-1748	232	31	,	,	PUNCT
eurjchem-1748	232	32	no	no	DET
eurjchem-1748	232	33	such	such	ADJ
eurjchem-1748	232	34	significant	significant	ADJ
eurjchem-1748	232	35	decrease	decrease	NOUN
eurjchem-1748	232	36	was	be	AUX
eurjchem-1748	232	37	observed	observe	VERB
eurjchem-1748	232	38	in	in	ADP
eurjchem-1748	232	39	non	non	ADJ
eurjchem-1748	232	40	-	-	ADJ
eurjchem-1748	232	41	treated	treat	VERB
eurjchem-1748	232	42	groups	group	NOUN
eurjchem-1748	232	43	.	.	PUNCT
eurjchem-1748	233	1	in	in	ADP
eurjchem-1748	233	2	the	the	DET
eurjchem-1748	233	3	effect	effect	NOUN
eurjchem-1748	233	4	on	on	ADP
eurjchem-1748	233	5	hypoglycemia	hypoglycemia	NOUN
eurjchem-1748	233	6	,	,	PUNCT
eurjchem-1748	233	7	a	a	DET
eurjchem-1748	233	8	reduction	reduction	NOUN
eurjchem-1748	233	9	in	in	ADP
eurjchem-1748	233	10	blood	blood	NOUN
eurjchem-1748	233	11	glucose	glucose	NOUN
eurjchem-1748	233	12	levels	level	NOUN
eurjchem-1748	233	13	was	be	AUX
eurjchem-1748	233	14	observed	observe	VERB
eurjchem-1748	233	15	on	on	ADP
eurjchem-1748	233	16	treatment	treatment	NOUN
eurjchem-1748	233	17	with	with	ADP
eurjchem-1748	233	18	cycle	cycle	NOUN
eurjchem-1748	233	19	inhibiting	inhibit	VERB
eurjchem-1748	233	20	factor	factor	NOUN
eurjchem-1748	233	21	(	(	PUNCT
eurjchem-1748	233	22	cif	cif	PROPN
eurjchem-1748	233	23	)	)	PUNCT
eurjchem-1748	233	24	in	in	ADP
eurjchem-1748	233	25	both	both	PRON
eurjchem-1748	233	26	pre	pre	VERB
eurjchem-1748	233	27	and	and	CCONJ
eurjchem-1748	233	28	post	post	VERB
eurjchem-1748	233	29	treated	treat	VERB
eurjchem-1748	233	30	rats	rat	NOUN
eurjchem-1748	233	31	on	on	ADP
eurjchem-1748	233	32	14th	14th	ADJ
eurjchem-1748	233	33	and	and	CCONJ
eurjchem-1748	233	34	21st	21st	ADJ
eurjchem-1748	233	35	day	day	NOUN
eurjchem-1748	233	36	(	(	PUNCT
eurjchem-1748	233	37	table	table	NOUN
eurjchem-1748	233	38	3	3	NUM
eurjchem-1748	233	39	)	)	PUNCT
eurjchem-1748	233	40	.	.	PUNCT
eurjchem-1748	234	1	3.4	3.4	NUM
eurjchem-1748	234	2	.	.	PUNCT
eurjchem-1748	234	3	morphological	morphological	ADJ
eurjchem-1748	234	4	changes	change	NOUN
eurjchem-1748	234	5	and	and	CCONJ
eurjchem-1748	234	6	mortality	mortality	NOUN
eurjchem-1748	234	7	table	table	NOUN
eurjchem-1748	234	8	3	3	NUM
eurjchem-1748	234	9	illustrated	illustrate	VERB
eurjchem-1748	234	10	the	the	DET
eurjchem-1748	234	11	diabetic	diabetic	ADJ
eurjchem-1748	234	12	successful	successful	ADJ
eurjchem-1748	234	13	rate	rate	NOUN
eurjchem-1748	234	14	(	(	PUNCT
eurjchem-1748	234	15	dsr	dsr	NOUN
eurjchem-1748	234	16	)	)	PUNCT
eurjchem-1748	234	17	in	in	ADP
eurjchem-1748	234	18	rats	rat	NOUN
eurjchem-1748	234	19	which	which	PRON
eurjchem-1748	234	20	were	be	AUX
eurjchem-1748	234	21	active	active	ADJ
eurjchem-1748	234	22	in	in	ADP
eurjchem-1748	234	23	in	in	ADP
eurjchem-1748	234	24	-	-	PUNCT
eurjchem-1748	234	25	vivo	vivo	NOUN
eurjchem-1748	234	26	studies	study	NOUN
eurjchem-1748	234	27	where	where	SCONJ
eurjchem-1748	234	28	few	few	ADJ
eurjchem-1748	234	29	compounds	compound	NOUN
eurjchem-1748	234	30	showed	show	VERB
eurjchem-1748	234	31	(	(	PUNCT
eurjchem-1748	234	32	compounds	compound	NOUN
eurjchem-1748	234	33	8	8	NUM
eurjchem-1748	234	34	,	,	PUNCT
eurjchem-1748	234	35	13	13	NUM
eurjchem-1748	234	36	,	,	PUNCT
eurjchem-1748	234	37	14	14	NUM
eurjchem-1748	234	38	,	,	PUNCT
eurjchem-1748	234	39	22	22	NUM
eurjchem-1748	234	40	and	and	CCONJ
eurjchem-1748	234	41	27	27	NUM
eurjchem-1748	234	42	)	)	PUNCT
eurjchem-1748	234	43	activity	activity	NOUN
eurjchem-1748	234	44	against	against	ADP
eurjchem-1748	234	45	α	α	NOUN
eurjchem-1748	234	46	-	-	PUNCT
eurjchem-1748	234	47	glucodiase	glucodiase	NOUN
eurjchem-1748	234	48	inhibition	inhibition	NOUN
eurjchem-1748	234	49	.	.	PUNCT
eurjchem-1748	235	1	the	the	DET
eurjchem-1748	235	2	in	in	ADP
eurjchem-1748	235	3	-	-	PUNCT
eurjchem-1748	235	4	silico	silico	NOUN
eurjchem-1748	235	5	and	and	CCONJ
eurjchem-1748	235	6	invitro	invitro	ADJ
eurjchem-1748	235	7	results	result	NOUN
eurjchem-1748	235	8	are	be	AUX
eurjchem-1748	235	9	also	also	ADV
eurjchem-1748	235	10	in	in	ADP
eurjchem-1748	235	11	accordance	accordance	NOUN
eurjchem-1748	235	12	with	with	ADP
eurjchem-1748	235	13	in	in	ADP
eurjchem-1748	235	14	-	-	PUNCT
eurjchem-1748	235	15	vivo	vivo	ADJ
eurjchem-1748	235	16	experimental	experimental	ADJ
eurjchem-1748	235	17	output	output	NOUN
eurjchem-1748	235	18	.	.	PUNCT
eurjchem-1748	236	1	on	on	ADP
eurjchem-1748	236	2	hfd	hfd	PROPN
eurjchem-1748	236	3	/	/	SYM
eurjchem-1748	236	4	stz	stz	NOUN
eurjchem-1748	236	5	induced	induce	VERB
eurjchem-1748	236	6	type	type	NOUN
eurjchem-1748	236	7	2	2	NUM
eurjchem-1748	236	8	diabetes	diabetes	NOUN
eurjchem-1748	236	9	mellitus	mellitus	NOUN
eurjchem-1748	236	10	was	be	AUX
eurjchem-1748	236	11	studied	study	VERB
eurjchem-1748	236	12	by	by	ADP
eurjchem-1748	236	13	administering	administer	VERB
eurjchem-1748	236	14	the	the	DET
eurjchem-1748	236	15	drugs	drug	NOUN
eurjchem-1748	236	16	at	at	ADP
eurjchem-1748	236	17	a	a	DET
eurjchem-1748	236	18	dose	dose	NOUN
eurjchem-1748	236	19	of	of	ADP
eurjchem-1748	236	20	200	200	NUM
eurjchem-1748	236	21	mg	mg	NOUN
eurjchem-1748	236	22	/	/	SYM
eurjchem-1748	236	23	kg	kg	PROPN
eurjchem-1748	236	24	bw	bw	PROPN
eurjchem-1748	236	25	p.o	p.o	PROPN
eurjchem-1748	236	26	.	.	PROPN
eurjchem-1748	236	27	and	and	CCONJ
eurjchem-1748	236	28	pioglitazone	pioglitazone	NOUN
eurjchem-1748	236	29	(	(	PUNCT
eurjchem-1748	236	30	2.7	2.7	NUM
eurjchem-1748	236	31	mg	mg	PROPN
eurjchem-1748	236	32	/	/	SYM
eurjchem-1748	236	33	kg	kg	PROPN
eurjchem-1748	236	34	p.o	p.o	PROPN
eurjchem-1748	236	35	.	.	PROPN
eurjchem-1748	236	36	)	)	PUNCT
eurjchem-1748	236	37	to	to	ADP
eurjchem-1748	236	38	the	the	DET
eurjchem-1748	236	39	positive	positive	ADJ
eurjchem-1748	236	40	control	control	NOUN
eurjchem-1748	236	41	group	group	NOUN
eurjchem-1748	236	42	for	for	ADP
eurjchem-1748	236	43	21	21	NUM
eurjchem-1748	236	44	days	day	NOUN
eurjchem-1748	236	45	,	,	PUNCT
eurjchem-1748	236	46	respectively	respectively	ADV
eurjchem-1748	236	47	.	.	PUNCT
eurjchem-1748	237	1	fasting	fast	VERB
eurjchem-1748	237	2	blood	blood	NOUN
eurjchem-1748	237	3	glucose	glucose	NOUN
eurjchem-1748	237	4	levels	level	NOUN
eurjchem-1748	237	5	were	be	AUX
eurjchem-1748	237	6	estimated	estimate	VERB
eurjchem-1748	237	7	using	use	VERB
eurjchem-1748	237	8	glucometer	glucometer	NOUN
eurjchem-1748	237	9	(	(	PUNCT
eurjchem-1748	237	10	accu	accu	PROPN
eurjchem-1748	237	11	-	-	ADJ
eurjchem-1748	237	12	chek	chek	ADJ
eurjchem-1748	237	13	active	active	ADJ
eurjchem-1748	237	14	tm	tm	PRON
eurjchem-1748	237	15	test	test	NOUN
eurjchem-1748	237	16	meter	meter	NOUN
eurjchem-1748	237	17	)	)	PUNCT
eurjchem-1748	237	18	on	on	ADP
eurjchem-1748	237	19	day	day	NOUN
eurjchem-1748	237	20	1	1	NUM
eurjchem-1748	237	21	,	,	PUNCT
eurjchem-1748	237	22	7	7	NUM
eurjchem-1748	237	23	,	,	PUNCT
eurjchem-1748	237	24	14	14	NUM
eurjchem-1748	237	25	and	and	CCONJ
eurjchem-1748	237	26	21	21	NUM
eurjchem-1748	237	27	.	.	PUNCT
eurjchem-1748	238	1	the	the	DET
eurjchem-1748	238	2	percentage	percentage	NOUN
eurjchem-1748	238	3	reduction	reduction	NOUN
eurjchem-1748	238	4	in	in	ADP
eurjchem-1748	238	5	blood	blood	NOUN
eurjchem-1748	238	6	glucose	glucose	NOUN
eurjchem-1748	238	7	levels	level	NOUN
eurjchem-1748	238	8	was	be	AUX
eurjchem-1748	238	9	estimated	estimate	VERB
eurjchem-1748	238	10	and	and	CCONJ
eurjchem-1748	238	11	compared	compare	VERB
eurjchem-1748	238	12	with	with	ADP
eurjchem-1748	238	13	that	that	PRON
eurjchem-1748	238	14	of	of	ADP
eurjchem-1748	238	15	normal	normal	ADJ
eurjchem-1748	238	16	control	control	NOUN
eurjchem-1748	238	17	and	and	CCONJ
eurjchem-1748	238	18	stz	stz	VERB
eurjchem-1748	238	19	treated	treat	VERB
eurjchem-1748	238	20	(	(	PUNCT
eurjchem-1748	238	21	negative	negative	ADJ
eurjchem-1748	238	22	control	control	NOUN
eurjchem-1748	238	23	)	)	PUNCT
eurjchem-1748	238	24	groups	group	NOUN
eurjchem-1748	238	25	.	.	PUNCT
eurjchem-1748	239	1	4	4	X
eurjchem-1748	239	2	.	.	X
eurjchem-1748	239	3	conclusion	conclusion	VERB
eurjchem-1748	239	4	our	our	PRON
eurjchem-1748	239	5	investigation	investigation	NOUN
eurjchem-1748	239	6	unveils	unveil	VERB
eurjchem-1748	239	7	new	new	ADJ
eurjchem-1748	239	8	c-7	c-7	NOUN
eurjchem-1748	239	9	substituted-2morpholino	substituted-2morpholino	PROPN
eurjchem-1748	239	10	-	-	PUNCT
eurjchem-1748	239	11	n-(pyridin-2	n-(pyridin-2	ADP
eurjchem-1748	239	12	-	-	PUNCT
eurjchem-1748	239	13	ylmethyl)quinazolin-4	ylmethyl)quinazolin-4	NOUN
eurjchem-1748	239	14	-	-	PUNCT
eurjchem-1748	239	15	amine	amine	ADJ
eurjchem-1748	239	16	quni	quni	PROPN
eurjchem-1748	239	17	nazoline	nazoline	NOUN
eurjchem-1748	239	18	derivatives	derivative	NOUN
eurjchem-1748	239	19	and	and	CCONJ
eurjchem-1748	239	20	significant	significant	ADJ
eurjchem-1748	239	21	bioactivity	bioactivity	NOUN
eurjchem-1748	239	22	against	against	ADP
eurjchem-1748	239	23	αglucosidse	αglucosidse	NOUN
eurjchem-1748	239	24	inhibition	inhibition	NOUN
eurjchem-1748	239	25	activity	activity	NOUN
eurjchem-1748	239	26	.	.	PUNCT
eurjchem-1748	240	1	computational	computational	ADJ
eurjchem-1748	240	2	techniques	technique	NOUN
eurjchem-1748	240	3	played	play	VERB
eurjchem-1748	240	4	crucial	crucial	ADJ
eurjchem-1748	240	5	role	role	NOUN
eurjchem-1748	240	6	while	while	SCONJ
eurjchem-1748	240	7	prioritizing	prioritize	VERB
eurjchem-1748	240	8	the	the	DET
eurjchem-1748	240	9	core	core	NOUN
eurjchem-1748	240	10	molecules	molecule	NOUN
eurjchem-1748	240	11	and	and	CCONJ
eurjchem-1748	240	12	as	as	ADV
eurjchem-1748	240	13	well	well	ADV
eurjchem-1748	240	14	in	in	ADP
eurjchem-1748	240	15	structure	structure	NOUN
eurjchem-1748	240	16	activity	activity	NOUN
eurjchem-1748	240	17	relationship	relationship	NOUN
eurjchem-1748	240	18	activity	activity	NOUN
eurjchem-1748	240	19	of	of	ADP
eurjchem-1748	240	20	the	the	DET
eurjchem-1748	240	21	prioritized	prioritized	ADJ
eurjchem-1748	240	22	molecule	molecule	NOUN
eurjchem-1748	240	23	8	8	NUM
eurjchem-1748	240	24	of	of	ADP
eurjchem-1748	240	25	the	the	DET
eurjchem-1748	240	26	synthesized	synthesize	VERB
eurjchem-1748	240	27	molecules	molecule	NOUN
eurjchem-1748	240	28	out	out	ADP
eurjchem-1748	240	29	of	of	ADP
eurjchem-1748	240	30	20	20	NUM
eurjchem-1748	240	31	analogues	analogue	NOUN
eurjchem-1748	240	32	displayed	display	VERB
eurjchem-1748	240	33	interesting	interesting	ADJ
eurjchem-1748	240	34	α	α	ADJ
eurjchem-1748	240	35	-	-	ADJ
eurjchem-1748	240	36	glucosidase	glucosidase	ADJ
eurjchem-1748	240	37	activity	activity	NOUN
eurjchem-1748	240	38	that	that	PRON
eurjchem-1748	240	39	is	be	AUX
eurjchem-1748	240	40	ic50	ic50	PROPN
eurjchem-1748	240	41	values	value	NOUN
eurjchem-1748	240	42	<	<	X
eurjchem-1748	240	43	2	2	NUM
eurjchem-1748	240	44	μm	μm	NOUN
eurjchem-1748	240	45	and	and	CCONJ
eurjchem-1748	240	46	those	those	DET
eurjchem-1748	240	47	lead	lead	NOUN
eurjchem-1748	240	48	compounds	compound	VERB
eurjchem-1748	240	49	possesses	possesse	NOUN
eurjchem-1748	240	50	required	require	VERB
eurjchem-1748	240	51	physicochemical	physicochemical	ADJ
eurjchem-1748	240	52	properties	property	NOUN
eurjchem-1748	240	53	and	and	CCONJ
eurjchem-1748	240	54	vital	vital	ADJ
eurjchem-1748	240	55	candidates	candidate	NOUN
eurjchem-1748	240	56	for	for	ADP
eurjchem-1748	240	57	further	further	ADJ
eurjchem-1748	240	58	lead	lead	NOUN
eurjchem-1748	240	59	optimization	optimization	NOUN
eurjchem-1748	240	60	.	.	PUNCT
eurjchem-1748	241	1	acknowledgements	acknowledgement	NOUN
eurjchem-1748	241	2	we	we	PRON
eurjchem-1748	241	3	acknowledge	acknowledge	VERB
eurjchem-1748	241	4	science	science	NOUN
eurjchem-1748	241	5	and	and	CCONJ
eurjchem-1748	241	6	engineering	engineering	NOUN
eurjchem-1748	241	7	research	research	NOUN
eurjchem-1748	241	8	board	board	NOUN
eurjchem-1748	241	9	(	(	PUNCT
eurjchem-1748	241	10	serb	serb	PROPN
eurjchem-1748	241	11	)	)	PUNCT
eurjchem-1748	241	12	india	india	PROPN
eurjchem-1748	241	13	and	and	CCONJ
eurjchem-1748	241	14	gandhi	gandhi	PROPN
eurjchem-1748	241	15	institute	institute	PROPN
eurjchem-1748	241	16	of	of	ADP
eurjchem-1748	241	17	technology	technology	NOUN
eurjchem-1748	241	18	and	and	CCONJ
eurjchem-1748	241	19	management	management	NOUN
eurjchem-1748	241	20	(	(	PUNCT
eurjchem-1748	241	21	gitam	gitam	NOUN
eurjchem-1748	241	22	)	)	PUNCT
eurjchem-1748	241	23	university	university	NOUN
eurjchem-1748	241	24	school	school	NOUN
eurjchem-1748	241	25	of	of	ADP
eurjchem-1748	241	26	science	science	NOUN
eurjchem-1748	241	27	,	,	PUNCT
eurjchem-1748	241	28	departmet	departmet	VERB
eurjchem-1748	241	29	of	of	ADP
eurjchem-1748	241	30	chemistry	chemistry	NOUN
eurjchem-1748	241	31	,	,	PUNCT
eurjchem-1748	241	32	hyderabad	hyderabad	PROPN
eurjchem-1748	241	33	.	.	PUNCT
eurjchem-1748	242	1	2018	2018	NUM
eurjchem-1748	242	2	–	–	PUNCT
eurjchem-1748	242	3	european	european	ADJ
eurjchem-1748	242	4	journal	journal	NOUN
eurjchem-1748	242	5	of	of	ADP
eurjchem-1748	242	6	chemistry	chemistry	NOUN
eurjchem-1748	242	7	–	–	PUNCT
eurjchem-1748	242	8	cc	cc	NOUN
eurjchem-1748	242	9	by	by	ADP
eurjchem-1748	242	10	nc	nc	PROPN
eurjchem-1748	242	11	–	–	PUNCT
eurjchem-1748	242	12	doi	doi	PROPN
eurjchem-1748	242	13	:	:	PUNCT
eurjchem-1748	242	14	10.5155	10.5155	NUM
eurjchem-1748	242	15	/	/	SYM
eurjchem-1748	242	16	eurjchem.9.4.322	eurjchem.9.4.322	PROPN
eurjchem-1748	242	17	-	-	PUNCT
eurjchem-1748	242	18	330.1748	330.1748	NUM
eurjchem-1748	242	19	330	330	NUM
eurjchem-1748	242	20	ankireddy	ankireddy	NOUN
eurjchem-1748	242	21	et	et	PROPN
eurjchem-1748	242	22	al	al	PROPN
eurjchem-1748	242	23	.	.	PUNCT
eurjchem-1748	242	24	/	/	SYM
eurjchem-1748	242	25	european	european	PROPN
eurjchem-1748	242	26	journal	journal	PROPN
eurjchem-1748	242	27	of	of	ADP
eurjchem-1748	242	28	chemistry	chemistry	NOUN
eurjchem-1748	242	29	9	9	NUM
eurjchem-1748	242	30	(	(	PUNCT
eurjchem-1748	242	31	4	4	NUM
eurjchem-1748	242	32	)	)	PUNCT
eurjchem-1748	242	33	(	(	PUNCT
eurjchem-1748	242	34	2018	2018	NUM
eurjchem-1748	242	35	)	)	PUNCT
eurjchem-1748	242	36	322	322	NUM
eurjchem-1748	242	37	-	-	SYM
eurjchem-1748	242	38	330	330	NUM
eurjchem-1748	242	39	disclosure	disclosure	NOUN
eurjchem-1748	242	40	statement	statement	NOUN
eurjchem-1748	242	41	conflict	conflict	NOUN
eurjchem-1748	242	42	of	of	ADP
eurjchem-1748	242	43	interests	interest	NOUN
eurjchem-1748	242	44	:	:	PUNCT
eurjchem-1748	242	45	authors	author	NOUN
eurjchem-1748	242	46	declare	declare	VERB
eurjchem-1748	242	47	no	no	DET
eurjchem-1748	242	48	conflict	conflict	NOUN
eurjchem-1748	242	49	of	of	ADP
eurjchem-1748	242	50	interest	interest	NOUN
eurjchem-1748	242	51	.	.	PUNCT
eurjchem-1748	243	1	author	author	NOUN
eurjchem-1748	243	2	contributions	contribution	NOUN
eurjchem-1748	243	3	:	:	PUNCT
eurjchem-1748	243	4	all	all	DET
eurjchem-1748	243	5	authors	author	NOUN
eurjchem-1748	243	6	contributed	contribute	VERB
eurjchem-1748	243	7	equally	equally	ADV
eurjchem-1748	243	8	to	to	ADP
eurjchem-1748	243	9	this	this	DET
eurjchem-1748	243	10	work	work	NOUN
eurjchem-1748	243	11	.	.	PUNCT
eurjchem-1748	244	1	ethical	ethical	ADJ
eurjchem-1748	244	2	approval	approval	NOUN
eurjchem-1748	244	3	:	:	PUNCT
eurjchem-1748	245	1	all	all	DET
eurjchem-1748	245	2	ethical	ethical	ADJ
eurjchem-1748	245	3	guidelines	guideline	NOUN
eurjchem-1748	245	4	have	have	AUX
eurjchem-1748	245	5	been	be	AUX
eurjchem-1748	245	6	adhered	adhere	VERB
eurjchem-1748	245	7	.	.	PUNCT
eurjchem-1748	246	1	sample	sample	NOUN
eurjchem-1748	246	2	availability	availability	NOUN
eurjchem-1748	246	3	:	:	PUNCT
eurjchem-1748	246	4	samples	sample	NOUN
eurjchem-1748	246	5	of	of	ADP
eurjchem-1748	246	6	the	the	DET
eurjchem-1748	246	7	compounds	compound	NOUN
eurjchem-1748	246	8	are	be	AUX
eurjchem-1748	246	9	available	available	ADJ
eurjchem-1748	246	10	from	from	ADP
eurjchem-1748	246	11	the	the	DET
eurjchem-1748	246	12	author	author	NOUN
eurjchem-1748	246	13	.	.	PUNCT
eurjchem-1748	247	1	orcid	orcid	PROPN
eurjchem-1748	247	2	ashok	ashok	PROPN
eurjchem-1748	247	3	reddy	reddy	PROPN
eurjchem-1748	247	4	ankireddy	ankireddy	PROPN
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eurjchem-1748	247	7	rambabu	rambabu	NOUN
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eurjchem-1748	247	9	tuniki	tuniki	PROPN
eurjchem-1748	247	10	balaraju	balaraju	NOUN
eurjchem-1748	247	11	http://orcid.org/0000-0003-2466-1471	http://orcid.org/0000-0003-2466-1471	PROPN
eurjchem-1748	247	12	venkanna	venkanna	NUM
eurjchem-1748	247	13	banothu	banothu	PROPN
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eurjchem-1748	247	15	krishna	krishna	PROPN
eurjchem-1748	247	16	prasad	prasad	PROPN
eurjchem-1748	247	17	gundla	gundla	NOUN
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eurjchem-1748	247	19	uma	uma	PROPN
eurjchem-1748	247	20	addepally	addepally	ADV
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eurjchem-1748	247	22	jithendra	jithendra	PROPN
eurjchem-1748	247	23	chimakurthy	chimakurthy	PROPN
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eurjchem-1748	247	25	references	reference	NOUN
eurjchem-1748	247	26	[	[	X
eurjchem-1748	247	27	1	1	NUM
eurjchem-1748	247	28	]	]	PUNCT
eurjchem-1748	247	29	.	.	PUNCT
eurjchem-1748	248	1	geiss	geiss	PROPN
eurjchem-1748	248	2	,	,	PUNCT
eurjchem-1748	248	3	l.	l.	PROPN
eurjchem-1748	248	4	s.	s.	PROPN
eurjchem-1748	248	5	;	;	PUNCT
eurjchem-1748	248	6	wang	wang	PROPN
eurjchem-1748	248	7	,	,	PUNCT
eurjchem-1748	248	8	j.	j.	PROPN
eurjchem-1748	248	9	;	;	PUNCT
eurjchem-1748	248	10	cheng	cheng	PROPN
eurjchem-1748	248	11	,	,	PUNCT
eurjchem-1748	248	12	y.	y.	PROPN
eurjchem-1748	248	13	j.	j.	PROPN
eurjchem-1748	248	14	;	;	PUNCT
eurjchem-1748	248	15	thompson	thompson	PROPN
eurjchem-1748	248	16	,	,	PUNCT
eurjchem-1748	248	17	t.	t.	PROPN
eurjchem-1748	248	18	j.	j.	PROPN
eurjchem-1748	248	19	;	;	PUNCT
eurjchem-1748	248	20	barker	barker	PROPN
eurjchem-1748	248	21	,	,	PUNCT
eurjchem-1748	248	22	l.	l.	PROPN
eurjchem-1748	248	23	;	;	PUNCT
eurjchem-1748	248	24	li	li	PROPN
eurjchem-1748	248	25	,	,	PUNCT
eurjchem-1748	248	26	y.	y.	PROPN
eurjchem-1748	248	27	;	;	PUNCT
eurjchem-1748	248	28	albright	albright	PROPN
eurjchem-1748	248	29	,	,	PUNCT
eurjchem-1748	248	30	a.	a.	PROPN
eurjchem-1748	248	31	l.	l.	PROPN
eurjchem-1748	248	32	;	;	PUNCT
eurjchem-1748	248	33	gregg	gregg	PROPN
eurjchem-1748	248	34	,	,	PUNCT
eurjchem-1748	248	35	e.	e.	PROPN
eurjchem-1748	248	36	w.	w.	PROPN
eurjchem-1748	248	37	jama	jama	PROPN
eurjchem-1748	248	38	2014	2014	NUM
eurjchem-1748	248	39	,	,	PUNCT
eurjchem-1748	248	40	312	312	NUM
eurjchem-1748	248	41	,	,	PUNCT
eurjchem-1748	248	42	1218	1218	NUM
eurjchem-1748	248	43	-	-	SYM
eurjchem-1748	248	44	1226	1226	NUM
eurjchem-1748	248	45	.	.	PUNCT
eurjchem-1748	249	1	[	[	X
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eurjchem-1748	249	3	]	]	PUNCT
eurjchem-1748	249	4	.	.	PUNCT
eurjchem-1748	250	1	ferreres	ferrere	NOUN
eurjchem-1748	250	2	,	,	PUNCT
eurjchem-1748	250	3	f.	f.	PROPN
eurjchem-1748	250	4	;	;	PUNCT
eurjchem-1748	250	5	gil	gil	PROPN
eurjchem-1748	250	6	-	-	PUNCT
eurjchem-1748	250	7	izquierdo	izquierdo	PROPN
eurjchem-1748	250	8	,	,	PUNCT
eurjchem-1748	250	9	a.	a.	NOUN
eurjchem-1748	250	10	;	;	PUNCT
eurjchem-1748	250	11	vinholes	vinhole	NOUN
eurjchem-1748	250	12	,	,	PUNCT
eurjchem-1748	250	13	j.	j.	PROPN
eurjchem-1748	250	14	;	;	PUNCT
eurjchem-1748	250	15	silva	silva	PROPN
eurjchem-1748	250	16	,	,	PUNCT
eurjchem-1748	250	17	s.	s.	PROPN
eurjchem-1748	250	18	t.	t.	PROPN
eurjchem-1748	250	19	;	;	PUNCT
eurjchem-1748	250	20	valentao	valentao	PROPN
eurjchem-1748	250	21	,	,	PUNCT
eurjchem-1748	250	22	p.	p.	PROPN
eurjchem-1748	250	23	;	;	PUNCT
eurjchem-1748	250	24	andrade	andrade	PROPN
eurjchem-1748	250	25	,	,	PUNCT
eurjchem-1748	250	26	p.	p.	PROPN
eurjchem-1748	250	27	b.	b.	PROPN
eurjchem-1748	251	1	food	food	NOUN
eurjchem-1748	251	2	chem	chem	PROPN
eurjchem-1748	251	3	.	.	PUNCT
eurjchem-1748	252	1	2012	2012	NUM
eurjchem-1748	252	2	,	,	PUNCT
eurjchem-1748	252	3	134	134	NUM
eurjchem-1748	252	4	,	,	PUNCT
eurjchem-1748	252	5	894	894	NUM
eurjchem-1748	252	6	-	-	SYM
eurjchem-1748	252	7	904	904	NUM
eurjchem-1748	252	8	.	.	PUNCT
eurjchem-1748	253	1	[	[	X
eurjchem-1748	253	2	3	3	NUM
eurjchem-1748	253	3	]	]	PUNCT
eurjchem-1748	253	4	.	.	PUNCT
eurjchem-1748	253	5	bruni	bruni	PROPN
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eurjchem-1748	253	11	v.	v.	PROPN
eurjchem-1748	253	12	;	;	PUNCT
eurjchem-1748	253	13	auricchio	auricchio	PROPN
eurjchem-1748	253	14	,	,	PUNCT
eurjchem-1748	253	15	f.	f.	PROPN
eurjchem-1748	253	16	;	;	PUNCT
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eurjchem-1748	253	21	.	.	PUNCT
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eurjchem-1748	254	2	.	.	PUNCT
eurjchem-1748	255	1	acta	acta	PROPN
eurjchem-1748	255	2	(	(	PUNCT
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eurjchem-1748	255	6	,	,	PUNCT
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eurjchem-1748	255	8	,	,	PUNCT
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eurjchem-1748	255	12	.	.	PUNCT
eurjchem-1748	256	1	[	[	X
eurjchem-1748	256	2	4	4	NUM
eurjchem-1748	256	3	]	]	PUNCT
eurjchem-1748	256	4	.	.	PUNCT
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eurjchem-1748	257	8	;	;	PUNCT
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eurjchem-1748	257	20	v.	v.	PROPN
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eurjchem-1748	257	22	;	;	PUNCT
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eurjchem-1748	258	1	[	[	X
eurjchem-1748	258	2	5	5	NUM
eurjchem-1748	258	3	]	]	PUNCT
eurjchem-1748	258	4	.	.	PUNCT
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eurjchem-1748	259	2	,	,	PUNCT
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eurjchem-1748	259	15	k.	k.	PROPN
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eurjchem-1748	259	21	;	;	PUNCT
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eurjchem-1748	259	25	;	;	PUNCT
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eurjchem-1748	259	28	p.	p.	PROPN
eurjchem-1748	259	29	k.	k.	PROPN
eurjchem-1748	259	30	;	;	PUNCT
eurjchem-1748	260	1	chaudhary	chaudhary	PROPN
eurjchem-1748	260	2	,	,	PUNCT
eurjchem-1748	260	3	a.	a.	PROPN
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eurjchem-1748	260	5	;	;	PUNCT
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eurjchem-1748	260	7	,	,	PUNCT
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eurjchem-1748	260	14	.	.	PUNCT
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eurjchem-1748	261	2	.	.	PUNCT
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eurjchem-1748	262	2	,	,	PUNCT
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eurjchem-1748	262	4	,	,	PUNCT
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eurjchem-1748	262	6	-	-	SYM
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eurjchem-1748	262	8	.	.	PUNCT
eurjchem-1748	263	1	[	[	X
eurjchem-1748	263	2	6	6	NUM
eurjchem-1748	263	3	]	]	PUNCT
eurjchem-1748	263	4	.	.	PUNCT
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eurjchem-1748	263	9	;	;	PUNCT
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eurjchem-1748	263	13	;	;	PUNCT
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eurjchem-1748	263	26	n.	n.	PROPN
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eurjchem-1748	263	28	;	;	PUNCT
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eurjchem-1748	263	30	,	,	PUNCT
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eurjchem-1748	263	32	;	;	PUNCT
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eurjchem-1748	264	1	j.	j.	PROPN
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eurjchem-1748	264	5	.	.	PUNCT
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eurjchem-1748	265	2	,	,	PUNCT
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eurjchem-1748	265	4	,	,	PUNCT
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eurjchem-1748	265	8	.	.	PUNCT
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eurjchem-1748	266	4	.	.	PUNCT
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eurjchem-1748	266	9	;	;	PUNCT
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eurjchem-1748	266	11	,	,	PUNCT
eurjchem-1748	266	12	b.	b.	PROPN
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eurjchem-1748	266	14	;	;	PUNCT
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eurjchem-1748	266	16	,	,	PUNCT
eurjchem-1748	266	17	a.	a.	PROPN
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eurjchem-1748	266	20	.	.	PUNCT
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eurjchem-1748	267	4	.	.	PUNCT
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eurjchem-1748	268	2	,	,	PUNCT
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eurjchem-1748	268	6	-	-	SYM
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eurjchem-1748	268	8	.	.	PUNCT
eurjchem-1748	269	1	[	[	X
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eurjchem-1748	269	3	]	]	PUNCT
eurjchem-1748	269	4	.	.	PUNCT
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eurjchem-1748	270	2	,	,	PUNCT
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eurjchem-1748	270	5	;	;	PUNCT
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eurjchem-1748	270	7	,	,	PUNCT
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eurjchem-1748	270	10	;	;	PUNCT
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eurjchem-1748	270	23	.	.	PUNCT
eurjchem-1748	271	1	[	[	X
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eurjchem-1748	271	4	.	.	PUNCT
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eurjchem-1748	272	2	,	,	PUNCT
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eurjchem-1748	272	5	;	;	PUNCT
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eurjchem-1748	273	4	.	.	PUNCT
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eurjchem-1748	280	5	;	;	PUNCT
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eurjchem-1748	280	9	;	;	PUNCT
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eurjchem-1748	280	14	;	;	PUNCT
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eurjchem-1748	280	18	;	;	PUNCT
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eurjchem-1748	283	21	.	.	PUNCT
eurjchem-1748	284	1	proc	proc	PROPN
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eurjchem-1748	285	2	.	.	PUNCT
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eurjchem-1748	286	7	700	700	NUM
eurjchem-1748	286	8	-	-	SYM
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eurjchem-1748	286	10	.	.	PUNCT
eurjchem-1748	287	1	[	[	X
eurjchem-1748	287	2	15	15	NUM
eurjchem-1748	287	3	]	]	PUNCT
eurjchem-1748	287	4	.	.	PUNCT
eurjchem-1748	287	5	friesner	friesner	PROPN
eurjchem-1748	287	6	,	,	PUNCT
eurjchem-1748	287	7	r.	r.	PROPN
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eurjchem-1748	287	9	;	;	PUNCT
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eurjchem-1748	287	19	;	;	PUNCT
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eurjchem-1748	287	32	t.	t.	PROPN
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eurjchem-1748	287	34	;	;	PUNCT
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eurjchem-1748	287	36	,	,	PUNCT
eurjchem-1748	287	37	p.	p.	PROPN
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eurjchem-1748	287	39	;	;	PUNCT
eurjchem-1748	288	1	mainz	mainz	PROPN
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eurjchem-1748	289	2	,	,	PUNCT
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eurjchem-1748	289	4	,	,	PUNCT
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eurjchem-1748	289	6	-	-	SYM
eurjchem-1748	289	7	6196	6196	NUM
eurjchem-1748	289	8	.	.	PUNCT
eurjchem-1748	290	1	[	[	X
eurjchem-1748	290	2	16	16	NUM
eurjchem-1748	290	3	]	]	PUNCT
eurjchem-1748	290	4	.	.	PUNCT
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eurjchem-1748	291	2	,	,	PUNCT
eurjchem-1748	291	3	j.	j.	PROPN
eurjchem-1748	291	4	;	;	PUNCT
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eurjchem-1748	291	6	,	,	PUNCT
eurjchem-1748	291	7	r.	r.	PROPN
eurjchem-1748	291	8	;	;	PUNCT
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eurjchem-1748	291	11	p.	p.	PROPN
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eurjchem-1748	291	13	;	;	PUNCT
eurjchem-1748	291	14	lu	lu	PROPN
eurjchem-1748	291	15	,	,	PUNCT
eurjchem-1748	291	16	k.	k.	PROPN
eurjchem-1748	291	17	;	;	PUNCT
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eurjchem-1748	291	19	,	,	PUNCT
eurjchem-1748	291	20	p.	p.	PROPN
eurjchem-1748	291	21	;	;	PUNCT
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eurjchem-1748	291	23	,	,	PUNCT
eurjchem-1748	291	24	s.	s.	PROPN
eurjchem-1748	291	25	clin	clin	PROPN
eurjchem-1748	291	26	.	.	PUNCT
eurjchem-1748	292	1	therap	therap	PROPN
eurjchem-1748	292	2	.	.	PUNCT
eurjchem-1748	293	1	2006	2006	NUM
eurjchem-1748	293	2	,	,	PUNCT
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eurjchem-1748	293	4	,	,	PUNCT
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eurjchem-1748	293	6	-	-	SYM
eurjchem-1748	293	7	1568	1568	NUM
eurjchem-1748	293	8	.	.	PUNCT
eurjchem-1748	294	1	[	[	X
eurjchem-1748	294	2	17	17	NUM
eurjchem-1748	294	3	]	]	PUNCT
eurjchem-1748	294	4	.	.	PUNCT
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eurjchem-1748	295	2	,	,	PUNCT
eurjchem-1748	295	3	t.	t.	PROPN
eurjchem-1748	295	4	;	;	PUNCT
eurjchem-1748	295	5	sakairi	sakairi	PROPN
eurjchem-1748	295	6	,	,	PUNCT
eurjchem-1748	295	7	k.	k.	PROPN
eurjchem-1748	295	8	;	;	PUNCT
eurjchem-1748	295	9	yamaguchi	yamaguchi	PROPN
eurjchem-1748	295	10	,	,	PUNCT
eurjchem-1748	295	11	e.	e.	PROPN
eurjchem-1748	295	12	;	;	PUNCT
eurjchem-1748	295	13	tada	tada	PROPN
eurjchem-1748	295	14	,	,	PUNCT
eurjchem-1748	295	15	n.	n.	NOUN
eurjchem-1748	295	16	;	;	PUNCT
eurjchem-1748	295	17	itoh	itoh	ADJ
eurjchem-1748	295	18	,	,	PUNCT
eurjchem-1748	295	19	a.	a.	PROPN
eurjchem-1748	295	20	rsc	rsc	PROPN
eurjchem-1748	295	21	adv	adv	PROPN
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eurjchem-1748	295	24	,	,	PUNCT
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eurjchem-1748	295	26	,	,	PUNCT
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eurjchem-1748	295	28	-	-	SYM
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eurjchem-1748	295	30	.	.	PUNCT
eurjchem-1748	296	1	[	[	X
eurjchem-1748	296	2	18	18	NUM
eurjchem-1748	296	3	]	]	PUNCT
eurjchem-1748	296	4	.	.	PUNCT
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eurjchem-1748	297	2	,	,	PUNCT
eurjchem-1748	297	3	a.	a.	NOUN
eurjchem-1748	297	4	;	;	PUNCT
eurjchem-1748	297	5	johnston	johnston	PROPN
eurjchem-1748	297	6	,	,	PUNCT
eurjchem-1748	297	7	b.	b.	PROPN
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eurjchem-1748	297	9	;	;	PUNCT
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eurjchem-1748	297	13	m.	m.	PROPN
eurjchem-1748	297	14	j.	j.	PROPN
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eurjchem-1748	297	16	.	.	PUNCT
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eurjchem-1748	297	18	.	.	PUNCT
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eurjchem-1748	298	2	,	,	PUNCT
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eurjchem-1748	298	4	,	,	PUNCT
eurjchem-1748	298	5	23122317	23122317	NUM
eurjchem-1748	298	6	.	.	PUNCT
eurjchem-1748	299	1	[	[	X
eurjchem-1748	299	2	19	19	NUM
eurjchem-1748	299	3	]	]	PUNCT
eurjchem-1748	299	4	.	.	PUNCT
eurjchem-1748	299	5	andrews	andrews	PROPN
eurjchem-1748	299	6	,	,	PUNCT
eurjchem-1748	299	7	j.	j.	PROPN
eurjchem-1748	299	8	s.	s.	PROPN
eurjchem-1748	299	9	;	;	PUNCT
eurjchem-1748	299	10	weimar	weimar	PROPN
eurjchem-1748	299	11	,	,	PUNCT
eurjchem-1748	299	12	t.	t.	PROPN
eurjchem-1748	299	13	;	;	PUNCT
eurjchem-1748	299	14	frandsen	frandsen	PROPN
eurjchem-1748	299	15	,	,	PUNCT
eurjchem-1748	299	16	t.	t.	PROPN
eurjchem-1748	299	17	p.	p.	PROPN
eurjchem-1748	299	18	;	;	PUNCT
eurjchem-1748	299	19	svensson	svensson	PROPN
eurjchem-1748	299	20	,	,	PUNCT
eurjchem-1748	299	21	b.	b.	PROPN
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eurjchem-1748	299	25	b.	b.	PROPN
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eurjchem-1748	299	29	.	.	PUNCT
eurjchem-1748	300	1	chem	chem	PROPN
eurjchem-1748	300	2	.	.	PUNCT
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eurjchem-1748	301	2	.	.	PUNCT
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eurjchem-1748	302	2	,	,	PUNCT
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eurjchem-1748	302	4	,	,	PUNCT
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eurjchem-1748	302	6	-	-	SYM
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eurjchem-1748	302	8	.	.	PUNCT
eurjchem-1748	303	1	[	[	X
eurjchem-1748	303	2	20	20	NUM
eurjchem-1748	303	3	]	]	PUNCT
eurjchem-1748	303	4	.	.	PUNCT
eurjchem-1748	304	1	flanagan	flanagan	PROPN
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eurjchem-1748	304	5	;	;	PUNCT
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eurjchem-1748	304	7	,	,	PUNCT
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eurjchem-1748	305	1	j.	j.	PROPN
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eurjchem-1748	305	3	,	,	PUNCT
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eurjchem-1748	305	7	-	-	SYM
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eurjchem-1748	306	1	[	[	X
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eurjchem-1748	306	3	]	]	PUNCT
eurjchem-1748	306	4	.	.	PUNCT
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eurjchem-1748	307	2	,	,	PUNCT
eurjchem-1748	307	3	t.	t.	PROPN
eurjchem-1748	307	4	;	;	PUNCT
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eurjchem-1748	307	8	;	;	PUNCT
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eurjchem-1748	307	12	;	;	PUNCT
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eurjchem-1748	307	20	;	;	PUNCT
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eurjchem-1748	307	25	;	;	PUNCT
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eurjchem-1748	307	30	.	.	PUNCT
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eurjchem-1748	308	2	.	.	PUNCT
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eurjchem-1748	309	2	,	,	PUNCT
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eurjchem-1748	309	6	-	-	SYM
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eurjchem-1748	309	8	.	.	PUNCT
eurjchem-1748	310	1	[	[	X
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eurjchem-1748	310	4	.	.	PUNCT
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eurjchem-1748	311	8	;	;	PUNCT
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eurjchem-1748	314	4	.	.	PUNCT
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eurjchem-1748	315	4	;	;	PUNCT
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eurjchem-1748	315	8	;	;	PUNCT
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eurjchem-1748	315	16	;	;	PUNCT
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eurjchem-1748	315	34	;	;	PUNCT
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eurjchem-1748	317	1	[	[	X
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eurjchem-1748	317	3	]	]	PUNCT
eurjchem-1748	317	4	.	.	PUNCT
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eurjchem-1748	318	4	;	;	PUNCT
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eurjchem-1748	318	8	;	;	PUNCT
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eurjchem-1748	318	12	;	;	PUNCT
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eurjchem-1748	318	20	;	;	PUNCT
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eurjchem-1748	318	24	;	;	PUNCT
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eurjchem-1748	321	6	-	-	SYM
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eurjchem-1748	356	25	;	;	PUNCT
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eurjchem-1748	356	41	;	;	PUNCT
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eurjchem-1748	357	2	,	,	PUNCT
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eurjchem-1748	357	4	)	)	PUNCT
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eurjchem-1748	357	7	-	-	SYM
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eurjchem-1748	357	9	.	.	PUNCT
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eurjchem-1748	358	3	]	]	PUNCT
eurjchem-1748	358	4	.	.	PUNCT
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eurjchem-1748	359	7	,	,	PUNCT
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eurjchem-1748	359	25	;	;	PUNCT
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eurjchem-1748	359	27	,	,	PUNCT
eurjchem-1748	359	28	s.	s.	PROPN
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eurjchem-1748	359	30	;	;	PUNCT
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eurjchem-1748	359	32	,	,	PUNCT
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eurjchem-1748	359	45	-	-	SYM
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eurjchem-1748	360	3	]	]	PUNCT
eurjchem-1748	360	4	.	.	PUNCT
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eurjchem-1748	361	21	,	,	PUNCT
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eurjchem-1748	361	23	)	)	PUNCT
eurjchem-1748	361	24	,	,	PUNCT
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eurjchem-1748	361	26	-	-	SYM
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eurjchem-1748	361	28	.	.	PUNCT
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eurjchem-1748	366	11	and	and	CCONJ
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eurjchem-1748	366	17	nc	nc	PROPN
eurjchem-1748	366	18	license	license	PROPN
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eurjchem-1748	366	23	non	non	ADJ
eurjchem-1748	366	24	-	-	ADJ
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eurjchem-1748	368	24	(	(	PUNCT
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eurjchem-1748	369	7	–	–	PUNCT
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eurjchem-1748	369	26	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	PROPN
eurjchem-1748	369	27	http://creativecommons.org/licenses/by-nc/4.0	http://creativecommons.org/licenses/by-nc/4.0	PROPN
eurjchem-1748	369	28	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	NOUN
eurjchem-1748	369	29	1	1	NUM
eurjchem-1748	369	30	.	.	PUNCT
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eurjchem-1748	370	2	2	2	NUM
eurjchem-1748	370	3	.	.	PUNCT
eurjchem-1748	370	4	experimental	experimental	ADJ
eurjchem-1748	370	5	2.1	2.1	NUM
eurjchem-1748	370	6	.	.	PUNCT
eurjchem-1748	371	1	synthesis	synthesis	NOUN
eurjchem-1748	371	2	2.2	2.2	NUM
eurjchem-1748	371	3	.	.	PUNCT
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eurjchem-1748	372	2	modelling	modelling	NOUN
eurjchem-1748	372	3	and	and	CCONJ
eurjchem-1748	372	4	drug	drug	NOUN
eurjchem-1748	372	5	design	design	NOUN
eurjchem-1748	372	6	2.3	2.3	NUM
eurjchem-1748	372	7	.	.	PUNCT
eurjchem-1748	373	1	preparation	preparation	NOUN
eurjchem-1748	373	2	of	of	ADP
eurjchem-1748	373	3	protein	protein	NOUN
eurjchem-1748	373	4	structures	structure	NOUN
eurjchem-1748	373	5	2.4	2.4	NUM
eurjchem-1748	373	6	.	.	PUNCT
eurjchem-1748	374	1	receptor	receptor	NOUN
eurjchem-1748	374	2	grid	grid	NOUN
eurjchem-1748	374	3	generation	generation	NOUN
eurjchem-1748	374	4	and	and	CCONJ
eurjchem-1748	374	5	docking	dock	VERB
eurjchem-1748	374	6	2.5	2.5	NUM
eurjchem-1748	374	7	.	.	PUNCT
eurjchem-1748	375	1	biology	biology	NOUN
eurjchem-1748	375	2	assays	assay	VERB
eurjchem-1748	375	3	2.6	2.6	NUM
eurjchem-1748	375	4	.	.	PUNCT
eurjchem-1748	376	1	in	in	ADP
eurjchem-1748	376	2	-	-	PUNCT
eurjchem-1748	376	3	vitro	vitro	X
eurjchem-1748	376	4	studies	study	NOUN
eurjchem-1748	376	5	2.7	2.7	NUM
eurjchem-1748	376	6	.	.	PUNCT
eurjchem-1748	376	7	animals	animal	NOUN
eurjchem-1748	376	8	and	and	CCONJ
eurjchem-1748	376	9	induction	induction	NOUN
eurjchem-1748	376	10	of	of	ADP
eurjchem-1748	376	11	t2	t2	NOUN
eurjchem-1748	376	12	dm	dm	NUM
eurjchem-1748	376	13	2.8	2.8	NUM
eurjchem-1748	376	14	.	.	PUNCT
eurjchem-1748	377	1	acute	acute	ADJ
eurjchem-1748	377	2	toxicity	toxicity	NOUN
eurjchem-1748	377	3	studies	study	NOUN
eurjchem-1748	377	4	3	3	NUM
eurjchem-1748	377	5	.	.	NOUN
eurjchem-1748	377	6	results	result	NOUN
eurjchem-1748	377	7	and	and	CCONJ
eurjchem-1748	377	8	discussion	discussion	NOUN
eurjchem-1748	377	9	3.1	3.1	NUM
eurjchem-1748	377	10	.	.	PUNCT
eurjchem-1748	378	1	molecular	molecular	ADJ
eurjchem-1748	378	2	modelling	modelling	NOUN
eurjchem-1748	378	3	and	and	CCONJ
eurjchem-1748	378	4	drug	drug	NOUN
eurjchem-1748	378	5	designing	design	VERB
eurjchem-1748	378	6	3.2	3.2	NUM
eurjchem-1748	378	7	.	.	PUNCT
eurjchem-1748	379	1	biochemical	biochemical	ADJ
eurjchem-1748	379	2	assay	assay	NOUN
eurjchem-1748	379	3	of	of	ADP
eurjchem-1748	379	4	the	the	DET
eurjchem-1748	379	5	synthesized	synthesize	VERB
eurjchem-1748	379	6	compounds	compound	NOUN
eurjchem-1748	379	7	(	(	PUNCT
eurjchem-1748	379	8	in	in	ADP
eurjchem-1748	379	9	-	-	PUNCT
eurjchem-1748	379	10	vitro	vitro	X
eurjchem-1748	379	11	study	study	NOUN
eurjchem-1748	379	12	)	)	PUNCT
eurjchem-1748	379	13	3.3	3.3	NUM
eurjchem-1748	379	14	.	.	PUNCT
eurjchem-1748	380	1	in	in	ADP
eurjchem-1748	380	2	-	-	PUNCT
eurjchem-1748	380	3	vivo	vivo	NOUN
eurjchem-1748	380	4	study	study	NOUN
eurjchem-1748	380	5	3.4	3.4	NUM
eurjchem-1748	380	6	.	.	PUNCT
eurjchem-1748	381	1	morphological	morphological	ADJ
eurjchem-1748	381	2	changes	change	NOUN
eurjchem-1748	381	3	and	and	CCONJ
eurjchem-1748	381	4	mortality	mortality	NOUN
eurjchem-1748	381	5	4	4	NUM
eurjchem-1748	381	6	.	.	PUNCT
eurjchem-1748	382	1	conclusion	conclusion	NOUN
eurjchem-1748	382	2	acknowledgements	acknowledgement	NOUN
eurjchem-1748	382	3	disclosure	disclosure	NOUN
eurjchem-1748	382	4	statement	statement	NOUN
eurjchem-1748	382	5	orcid	orcid	PROPN
eurjchem-1748	382	6	references	reference	NOUN
eurjchem-1748	382	7	printfield10	printfield10	NOUN
eurjchem-1748	382	8	:	:	PUNCT
eurjchem-1748	382	9	printfield11	printfield11	NOUN
eurjchem-1748	382	10	:	:	PUNCT
eurjchem-1748	382	11	printfield12	printfield12	PROPN
eurjchem-1748	382	12	:	:	PUNCT
eurjchem-1748	382	13	printfield13	printfield13	VERB
eurjchem-1748	382	14	:	:	PUNCT
eurjchem-1748	382	15	printfield14	printfield14	NOUN
eurjchem-1748	382	16	:	:	PUNCT
eurjchem-1748	382	17	printfield15	printfield15	NOUN
eurjchem-1748	382	18	:	:	PUNCT
eurjchem-1748	382	19	printfield16	printfield16	ADJ
eurjchem-1748	382	20	:	:	PUNCT
eurjchem-1748	382	21	printfield17	printfield17	NOUN
eurjchem-1748	382	22	:	:	PUNCT
eurjchem-1748	382	23	printfield18	printfield18	NOUN
eurjchem-1748	382	24	:	:	PUNCT
eurjchem-1748	382	25	printfield20	printfield20	PROPN
eurjchem-1748	382	26	:	:	PUNCT
eurjchem-1748	382	27	printfield21	printfield21	ADJ
eurjchem-1748	382	28	:	:	PUNCT
eurjchem-1748	382	29	printfield22	printfield22	NOUN
eurjchem-1748	382	30	:	:	PUNCT
eurjchem-1748	382	31	printfield23	printfield23	NOUN
eurjchem-1748	382	32	:	:	PUNCT
eurjchem-1748	382	33	printfield24	printfield24	NOUN
eurjchem-1748	382	34	:	:	PUNCT
eurjchem-1748	382	35	printfield25	printfield25	NOUN
eurjchem-1748	382	36	:	:	PUNCT
eurjchem-1748	382	37	printfield26	printfield26	ADJ
eurjchem-1748	382	38	:	:	PUNCT
eurjchem-1748	382	39	printfield27	printfield27	NOUN
eurjchem-1748	382	40	:	:	PUNCT
eurjchem-1748	382	41	printfield28	printfield28	NOUN
eurjchem-1748	382	42	:	:	PUNCT