id	sid	tid	token	lemma	pos
eurjchem-2103	1	1	molecular	molecular	ADJ
eurjchem-2103	1	2	docking	docking	NOUN
eurjchem-2103	1	3	analysis	analysis	NOUN
eurjchem-2103	1	4	on	on	ADP
eurjchem-2103	1	5	the	the	DET
eurjchem-2103	1	6	interaction	interaction	NOUN
eurjchem-2103	1	7	between	between	ADP
eurjchem-2103	1	8	bovine	bovine	PROPN
eurjchem-2103	1	9	serum	serum	NOUN
eurjchem-2103	1	10	albumin	albumin	NOUN
eurjchem-2103	1	11	and	and	CCONJ
eurjchem-2103	1	12	three	three	NUM
eurjchem-2103	1	13	commercial	commercial	ADJ
eurjchem-2103	1	14	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	1	15	:	:	PUNCT
eurjchem-2103	1	16	ciprofloxacin	ciprofloxacin	PROPN
eurjchem-2103	1	17	,	,	PUNCT
eurjchem-2103	1	18	enrofloxacin	enrofloxacin	PROPN
eurjchem-2103	1	19	and	and	CCONJ
eurjchem-2103	1	20	pefloxacin	pefloxacin	PROPN
eurjchem-2103	1	21	european	european	PROPN
eurjchem-2103	1	22	journal	journal	PROPN
eurjchem-2103	1	23	of	of	ADP
eurjchem-2103	1	24	chemistry	chemistry	NOUN
eurjchem-2103	1	25	12	12	NUM
eurjchem-2103	1	26	(	(	PUNCT
eurjchem-2103	1	27	2	2	NUM
eurjchem-2103	1	28	)	)	PUNCT
eurjchem-2103	1	29	(	(	PUNCT
eurjchem-2103	1	30	2021	2021	NUM
eurjchem-2103	1	31	)	)	PUNCT
eurjchem-2103	1	32	192	192	NUM
eurjchem-2103	1	33	-	-	SYM
eurjchem-2103	1	34	196	196	NUM
eurjchem-2103	1	35	european	european	ADJ
eurjchem-2103	1	36	journal	journal	PROPN
eurjchem-2103	1	37	of	of	ADP
eurjchem-2103	1	38	chemistry	chemistry	NOUN
eurjchem-2103	1	39	issn	issn	VERB
eurjchem-2103	1	40	2153	2153	NUM
eurjchem-2103	1	41	-	-	SYM
eurjchem-2103	1	42	2249	2249	NUM
eurjchem-2103	1	43	(	(	PUNCT
eurjchem-2103	1	44	print	print	NOUN
eurjchem-2103	1	45	)	)	PUNCT
eurjchem-2103	1	46	/	/	PUNCT
eurjchem-2103	1	47	issn	issn	PROPN
eurjchem-2103	1	48	2153	2153	NUM
eurjchem-2103	1	49	-	-	SYM
eurjchem-2103	1	50	2257	2257	NUM
eurjchem-2103	1	51	(	(	PUNCT
eurjchem-2103	1	52	online	online	ADJ
eurjchem-2103	1	53	)	)	PUNCT
eurjchem-2103	1	54	–	–	PUNCT
eurjchem-2103	2	1	copyright	copyright	NOUN
eurjchem-2103	2	2	©	©	PROPN
eurjchem-2103	2	3	2021	2021	NUM
eurjchem-2103	2	4	the	the	DET
eurjchem-2103	2	5	authors	author	NOUN
eurjchem-2103	2	6	–	–	PUNCT
eurjchem-2103	2	7	atlanta	atlanta	PROPN
eurjchem-2103	2	8	publishing	publishing	PROPN
eurjchem-2103	2	9	house	house	PROPN
eurjchem-2103	2	10	llc	llc	PROPN
eurjchem-2103	2	11	–	–	PUNCT
eurjchem-2103	2	12	printed	print	VERB
eurjchem-2103	2	13	in	in	ADP
eurjchem-2103	2	14	the	the	DET
eurjchem-2103	2	15	usa	usa	PROPN
eurjchem-2103	2	16	.	.	PUNCT
eurjchem-2103	3	1	this	this	DET
eurjchem-2103	3	2	work	work	NOUN
eurjchem-2103	3	3	is	be	AUX
eurjchem-2103	3	4	published	publish	VERB
eurjchem-2103	3	5	and	and	CCONJ
eurjchem-2103	3	6	licensed	license	VERB
eurjchem-2103	3	7	by	by	ADP
eurjchem-2103	3	8	atlanta	atlanta	PROPN
eurjchem-2103	3	9	publishing	publishing	PROPN
eurjchem-2103	3	10	house	house	PROPN
eurjchem-2103	3	11	llc	llc	PROPN
eurjchem-2103	3	12	–	–	PUNCT
eurjchem-2103	3	13	cc	cc	PROPN
eurjchem-2103	3	14	by	by	ADP
eurjchem-2103	3	15	nc	nc	PROPN
eurjchem-2103	3	16	–	–	PUNCT
eurjchem-2103	3	17	some	some	DET
eurjchem-2103	3	18	rights	right	NOUN
eurjchem-2103	3	19	reserved	reserve	VERB
eurjchem-2103	3	20	.	.	PUNCT
eurjchem-2103	4	1	https://dx.doi.org/10.5155/eurjchem.12.2.192-196.2103	https://dx.doi.org/10.5155/eurjchem.12.2.192-196.2103	PROPN
eurjchem-2103	4	2	european	european	PROPN
eurjchem-2103	4	3	journal	journal	PROPN
eurjchem-2103	4	4	of	of	ADP
eurjchem-2103	4	5	chemistry	chemistry	NOUN
eurjchem-2103	4	6	view	view	NOUN
eurjchem-2103	4	7	journal	journal	PROPN
eurjchem-2103	4	8	online	online	PROPN
eurjchem-2103	4	9	view	view	NOUN
eurjchem-2103	4	10	article	article	NOUN
eurjchem-2103	4	11	online	online	VERB
eurjchem-2103	4	12	molecular	molecular	ADJ
eurjchem-2103	4	13	docking	docking	NOUN
eurjchem-2103	4	14	analysis	analysis	NOUN
eurjchem-2103	4	15	on	on	ADP
eurjchem-2103	4	16	the	the	DET
eurjchem-2103	4	17	interaction	interaction	NOUN
eurjchem-2103	4	18	between	between	ADP
eurjchem-2103	4	19	bovine	bovine	PROPN
eurjchem-2103	4	20	serum	serum	NOUN
eurjchem-2103	4	21	albumin	albumin	NOUN
eurjchem-2103	4	22	and	and	CCONJ
eurjchem-2103	4	23	three	three	NUM
eurjchem-2103	4	24	commercial	commercial	ADJ
eurjchem-2103	4	25	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	4	26	:	:	PUNCT
eurjchem-2103	4	27	ciprofloxacin	ciprofloxacin	PROPN
eurjchem-2103	4	28	,	,	PUNCT
eurjchem-2103	4	29	enrofloxacin	enrofloxacin	PROPN
eurjchem-2103	4	30	and	and	CCONJ
eurjchem-2103	4	31	pefloxacin	pefloxacin	PROPN
eurjchem-2103	4	32	otávio	otávio	PROPN
eurjchem-2103	4	33	augusto	augusto	PROPN
eurjchem-2103	4	34	chaves	chave	NOUN
eurjchem-2103	4	35	*	*	PUNCT
eurjchem-2103	4	36	and	and	CCONJ
eurjchem-2103	4	37	leonardo	leonardo	PROPN
eurjchem-2103	4	38	vazquez	vazquez	PROPN
eurjchem-2103	4	39	laboratório	laboratório	PROPN
eurjchem-2103	4	40	de	de	PROPN
eurjchem-2103	4	41	imunofarmacologia	imunofarmacologia	PROPN
eurjchem-2103	4	42	,	,	PUNCT
eurjchem-2103	4	43	instituto	instituto	PROPN
eurjchem-2103	4	44	oswaldo	oswaldo	PROPN
eurjchem-2103	4	45	cruz	cruz	PROPN
eurjchem-2103	4	46	(	(	PUNCT
eurjchem-2103	4	47	ioc	ioc	PROPN
eurjchem-2103	4	48	)	)	PUNCT
eurjchem-2103	4	49	,	,	PUNCT
eurjchem-2103	4	50	fundação	fundação	ADJ
eurjchem-2103	4	51	oswaldo	oswaldo	PROPN
eurjchem-2103	4	52	cruz	cruz	PROPN
eurjchem-2103	4	53	(	(	PUNCT
eurjchem-2103	4	54	fiocruz	fiocruz	PROPN
eurjchem-2103	4	55	)	)	PUNCT
eurjchem-2103	4	56	,	,	PUNCT
eurjchem-2103	4	57	rio	rio	PROPN
eurjchem-2103	4	58	de	de	PROPN
eurjchem-2103	4	59	janeiro	janeiro	PROPN
eurjchem-2103	4	60	,	,	PUNCT
eurjchem-2103	4	61	21040	21040	NUM
eurjchem-2103	4	62	-	-	SYM
eurjchem-2103	4	63	900	900	NUM
eurjchem-2103	4	64	,	,	PUNCT
eurjchem-2103	4	65	brazil	brazil	PROPN
eurjchem-2103	4	66	otavio.chaves@ioc.fiocruz.br	otavio.chaves@ioc.fiocruz.br	ADJ
eurjchem-2103	4	67	(	(	PUNCT
eurjchem-2103	4	68	o.a.c	o.a.c	ADJ
eurjchem-2103	4	69	.	.	PUNCT
eurjchem-2103	4	70	)	)	PUNCT
eurjchem-2103	4	71	,	,	PUNCT
eurjchem-2103	4	72	leonardo_vazquez@hotmail.com	leonardo_vazquez@hotmail.com	NOUN
eurjchem-2103	4	73	(	(	PUNCT
eurjchem-2103	4	74	l.v	l.v	PROPN
eurjchem-2103	4	75	.	.	PUNCT
eurjchem-2103	4	76	)	)	PUNCT
eurjchem-2103	5	1	*	*	PUNCT
eurjchem-2103	5	2	corresponding	correspond	VERB
eurjchem-2103	5	3	author	author	NOUN
eurjchem-2103	5	4	at	at	ADP
eurjchem-2103	5	5	:	:	PUNCT
eurjchem-2103	5	6	laboratório	laboratório	PROPN
eurjchem-2103	5	7	de	de	PROPN
eurjchem-2103	5	8	imunofarmacologia	imunofarmacologia	PROPN
eurjchem-2103	5	9	,	,	PUNCT
eurjchem-2103	5	10	instituto	instituto	PROPN
eurjchem-2103	5	11	oswaldo	oswaldo	PROPN
eurjchem-2103	5	12	cruz	cruz	PROPN
eurjchem-2103	5	13	(	(	PUNCT
eurjchem-2103	5	14	ioc	ioc	PROPN
eurjchem-2103	5	15	)	)	PUNCT
eurjchem-2103	5	16	,	,	PUNCT
eurjchem-2103	5	17	fundação	fundação	ADJ
eurjchem-2103	5	18	oswaldo	oswaldo	PROPN
eurjchem-2103	5	19	cruz	cruz	PROPN
eurjchem-2103	5	20	(	(	PUNCT
eurjchem-2103	5	21	fiocruz	fiocruz	PROPN
eurjchem-2103	5	22	)	)	PUNCT
eurjchem-2103	5	23	,	,	PUNCT
eurjchem-2103	5	24	rio	rio	PROPN
eurjchem-2103	5	25	de	de	PROPN
eurjchem-2103	5	26	janeiro	janeiro	PROPN
eurjchem-2103	5	27	,	,	PUNCT
eurjchem-2103	5	28	21040	21040	NUM
eurjchem-2103	5	29	-	-	SYM
eurjchem-2103	5	30	900	900	NUM
eurjchem-2103	5	31	,	,	PUNCT
eurjchem-2103	5	32	brazil	brazil	PROPN
eurjchem-2103	5	33	.	.	PUNCT
eurjchem-2103	6	1	e	e	X
eurjchem-2103	6	2	-	-	NOUN
eurjchem-2103	6	3	mail	mail	NOUN
eurjchem-2103	6	4	:	:	PUNCT
eurjchem-2103	6	5	otavio.chaves@ioc.fiocruz.br	otavio.chaves@ioc.fiocruz.br	NUM
eurjchem-2103	6	6	(	(	PUNCT
eurjchem-2103	6	7	o.a	o.a	PROPN
eurjchem-2103	6	8	.	.	PROPN
eurjchem-2103	6	9	chaves	chaves	PROPN
eurjchem-2103	6	10	)	)	PUNCT
eurjchem-2103	6	11	.	.	PUNCT
eurjchem-2103	7	1	10.5155	10.5155	NUM
eurjchem-2103	7	2	/	/	SYM
eurjchem-2103	7	3	eurjchem.12.2.192	eurjchem.12.2.192	NOUN
eurjchem-2103	7	4	-	-	SYM
eurjchem-2103	7	5	196.2103	196.2103	NUM
eurjchem-2103	7	6	received	receive	VERB
eurjchem-2103	7	7	:	:	PUNCT
eurjchem-2103	7	8	31	31	NUM
eurjchem-2103	7	9	january	january	NOUN
eurjchem-2103	7	10	2021	2021	NUM
eurjchem-2103	7	11	received	receive	VERB
eurjchem-2103	7	12	in	in	ADP
eurjchem-2103	7	13	revised	revise	VERB
eurjchem-2103	7	14	form	form	NOUN
eurjchem-2103	7	15	:	:	PUNCT
eurjchem-2103	7	16	14	14	NUM
eurjchem-2103	7	17	march	march	NOUN
eurjchem-2103	7	18	2021	2021	NUM
eurjchem-2103	7	19	accepted	accept	VERB
eurjchem-2103	7	20	:	:	PUNCT
eurjchem-2103	7	21	28	28	NUM
eurjchem-2103	7	22	march	march	NOUN
eurjchem-2103	7	23	2021	2021	NUM
eurjchem-2103	7	24	published	publish	VERB
eurjchem-2103	7	25	online	online	ADV
eurjchem-2103	7	26	:	:	PUNCT
eurjchem-2103	7	27	30	30	NUM
eurjchem-2103	7	28	june	june	PROPN
eurjchem-2103	7	29	2021	2021	NUM
eurjchem-2103	7	30	printed	print	VERB
eurjchem-2103	7	31	:	:	PUNCT
eurjchem-2103	7	32	30	30	NUM
eurjchem-2103	7	33	june	june	PROPN
eurjchem-2103	7	34	2021	2021	NUM
eurjchem-2103	7	35	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	7	36	are	be	AUX
eurjchem-2103	7	37	a	a	DET
eurjchem-2103	7	38	family	family	NOUN
eurjchem-2103	7	39	of	of	ADP
eurjchem-2103	7	40	broad	broad	ADJ
eurjchem-2103	7	41	spectrum	spectrum	NOUN
eurjchem-2103	7	42	,	,	PUNCT
eurjchem-2103	7	43	systemic	systemic	ADJ
eurjchem-2103	7	44	antibacterial	antibacterial	ADJ
eurjchem-2103	7	45	agents	agent	NOUN
eurjchem-2103	7	46	that	that	PRON
eurjchem-2103	7	47	have	have	AUX
eurjchem-2103	7	48	been	be	AUX
eurjchem-2103	7	49	used	use	VERB
eurjchem-2103	7	50	as	as	ADP
eurjchem-2103	7	51	therapy	therapy	NOUN
eurjchem-2103	7	52	for	for	ADP
eurjchem-2103	7	53	infections	infection	NOUN
eurjchem-2103	7	54	in	in	ADP
eurjchem-2103	7	55	the	the	DET
eurjchem-2103	7	56	respiratory	respiratory	ADJ
eurjchem-2103	7	57	and	and	CCONJ
eurjchem-2103	7	58	alimentary	alimentary	ADJ
eurjchem-2103	7	59	tract	tract	NOUN
eurjchem-2103	7	60	in	in	ADP
eurjchem-2103	7	61	animals	animal	NOUN
eurjchem-2103	7	62	.	.	PUNCT
eurjchem-2103	8	1	the	the	DET
eurjchem-2103	8	2	pharmacodynamic	pharmacodynamic	ADJ
eurjchem-2103	8	3	of	of	ADP
eurjchem-2103	8	4	this	this	DET
eurjchem-2103	8	5	class	class	NOUN
eurjchem-2103	8	6	is	be	AUX
eurjchem-2103	8	7	widely	widely	ADV
eurjchem-2103	8	8	described	describe	VERB
eurjchem-2103	8	9	,	,	PUNCT
eurjchem-2103	8	10	predominantly	predominantly	ADV
eurjchem-2103	8	11	to	to	ADP
eurjchem-2103	8	12	the	the	DET
eurjchem-2103	8	13	commercial	commercial	ADJ
eurjchem-2103	8	14	drugs	drug	NOUN
eurjchem-2103	8	15	ciprofloxacin	ciprofloxacin	NOUN
eurjchem-2103	8	16	(	(	PUNCT
eurjchem-2103	8	17	cip	cip	PROPN
eurjchem-2103	8	18	)	)	PUNCT
eurjchem-2103	8	19	,	,	PUNCT
eurjchem-2103	8	20	enrofloxacin	enrofloxacin	PROPN
eurjchem-2103	8	21	(	(	PUNCT
eurjchem-2103	8	22	enr	enr	PROPN
eurjchem-2103	8	23	)	)	PUNCT
eurjchem-2103	8	24	,	,	PUNCT
eurjchem-2103	8	25	and	and	CCONJ
eurjchem-2103	8	26	pefloxacin	pefloxacin	PROPN
eurjchem-2103	8	27	(	(	PUNCT
eurjchem-2103	8	28	pef	pef	NOUN
eurjchem-2103	8	29	)	)	PUNCT
eurjchem-2103	8	30	.	.	PUNCT
eurjchem-2103	9	1	bovine	bovine	PROPN
eurjchem-2103	9	2	serum	serum	NOUN
eurjchem-2103	9	3	albumin	albumin	PROPN
eurjchem-2103	9	4	(	(	PUNCT
eurjchem-2103	9	5	bsa	bsa	PROPN
eurjchem-2103	9	6	)	)	PUNCT
eurjchem-2103	9	7	is	be	AUX
eurjchem-2103	9	8	the	the	DET
eurjchem-2103	9	9	main	main	ADJ
eurjchem-2103	9	10	endogenous	endogenous	ADJ
eurjchem-2103	9	11	carrier	carrier	NOUN
eurjchem-2103	9	12	in	in	ADP
eurjchem-2103	9	13	the	the	DET
eurjchem-2103	9	14	bovine	bovine	NOUN
eurjchem-2103	9	15	bloodstream	bloodstream	NOUN
eurjchem-2103	9	16	,	,	PUNCT
eurjchem-2103	9	17	being	be	AUX
eurjchem-2103	9	18	responsible	responsible	ADJ
eurjchem-2103	9	19	for	for	ADP
eurjchem-2103	9	20	the	the	DET
eurjchem-2103	9	21	biodistribution	biodistribution	NOUN
eurjchem-2103	9	22	of	of	ADP
eurjchem-2103	9	23	different	different	ADJ
eurjchem-2103	9	24	classes	class	NOUN
eurjchem-2103	9	25	of	of	ADP
eurjchem-2103	9	26	molecules	molecule	NOUN
eurjchem-2103	9	27	and	and	CCONJ
eurjchem-2103	9	28	drugs	drug	NOUN
eurjchem-2103	9	29	,	,	PUNCT
eurjchem-2103	9	30	including	include	VERB
eurjchem-2103	9	31	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	9	32	.	.	PUNCT
eurjchem-2103	10	1	the	the	DET
eurjchem-2103	10	2	molecular	molecular	ADJ
eurjchem-2103	10	3	features	feature	NOUN
eurjchem-2103	10	4	and	and	CCONJ
eurjchem-2103	10	5	interaction	interaction	NOUN
eurjchem-2103	10	6	between	between	ADP
eurjchem-2103	10	7	bsa	bsa	NOUN
eurjchem-2103	10	8	and	and	CCONJ
eurjchem-2103	10	9	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	10	10	are	be	AUX
eurjchem-2103	10	11	not	not	PART
eurjchem-2103	10	12	fully	fully	ADV
eurjchem-2103	10	13	described	describe	VERB
eurjchem-2103	10	14	,	,	PUNCT
eurjchem-2103	10	15	thus	thus	ADV
eurjchem-2103	10	16	,	,	PUNCT
eurjchem-2103	10	17	the	the	DET
eurjchem-2103	10	18	present	present	ADJ
eurjchem-2103	10	19	work	work	NOUN
eurjchem-2103	10	20	enlightens	enlighten	VERB
eurjchem-2103	10	21	the	the	DET
eurjchem-2103	10	22	intimacy	intimacy	NOUN
eurjchem-2103	10	23	of	of	ADP
eurjchem-2103	10	24	the	the	DET
eurjchem-2103	10	25	interaction	interaction	NOUN
eurjchem-2103	10	26	of	of	ADP
eurjchem-2103	10	27	bsa	bsa	PROPN
eurjchem-2103	10	28	with	with	ADP
eurjchem-2103	10	29	cip	cip	PROPN
eurjchem-2103	10	30	,	,	PUNCT
eurjchem-2103	10	31	enr	enr	PROPN
eurjchem-2103	10	32	,	,	PUNCT
eurjchem-2103	10	33	pef	pef	NOUN
eurjchem-2103	10	34	through	through	ADP
eurjchem-2103	10	35	structural	structural	ADJ
eurjchem-2103	10	36	modeling	modeling	NOUN
eurjchem-2103	10	37	and	and	CCONJ
eurjchem-2103	10	38	molecular	molecular	ADJ
eurjchem-2103	10	39	docking	docking	NOUN
eurjchem-2103	10	40	calculation	calculation	NOUN
eurjchem-2103	10	41	approaches	approach	NOUN
eurjchem-2103	10	42	.	.	PUNCT
eurjchem-2103	11	1	the	the	DET
eurjchem-2103	11	2	role	role	NOUN
eurjchem-2103	11	3	of	of	ADP
eurjchem-2103	11	4	key	key	ADJ
eurjchem-2103	11	5	amino	amino	NOUN
eurjchem-2103	11	6	acid	acid	NOUN
eurjchem-2103	11	7	residues	residue	NOUN
eurjchem-2103	11	8	was	be	AUX
eurjchem-2103	11	9	assessed	assess	VERB
eurjchem-2103	11	10	,	,	PUNCT
eurjchem-2103	11	11	indicating	indicate	VERB
eurjchem-2103	11	12	that	that	SCONJ
eurjchem-2103	11	13	the	the	DET
eurjchem-2103	11	14	main	main	ADJ
eurjchem-2103	11	15	protein	protein	NOUN
eurjchem-2103	11	16	binding	bind	VERB
eurjchem-2103	11	17	pocket	pocket	NOUN
eurjchem-2103	11	18	is	be	AUX
eurjchem-2103	11	19	composed	compose	VERB
eurjchem-2103	11	20	by	by	ADP
eurjchem-2103	11	21	trp-212	trp-212	ADJ
eurjchem-2103	11	22	residue	residue	NOUN
eurjchem-2103	11	23	playing	play	VERB
eurjchem-2103	11	24	an	an	DET
eurjchem-2103	11	25	important	important	ADJ
eurjchem-2103	11	26	stabilization	stabilization	NOUN
eurjchem-2103	11	27	for	for	ADP
eurjchem-2103	11	28	the	the	DET
eurjchem-2103	11	29	three	three	NUM
eurjchem-2103	11	30	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	11	31	through	through	ADP
eurjchem-2103	11	32	both	both	PRON
eurjchem-2103	11	33	hydrogen	hydrogen	NOUN
eurjchem-2103	11	34	bonding	bonding	NOUN
eurjchem-2103	11	35	and	and	CCONJ
eurjchem-2103	11	36	van	van	PROPN
eurjchem-2103	11	37	der	der	NOUN
eurjchem-2103	11	38	waals	waal	NOUN
eurjchem-2103	11	39	forces	force	NOUN
eurjchem-2103	11	40	,	,	PUNCT
eurjchem-2103	11	41	where	where	SCONJ
eurjchem-2103	11	42	reside	reside	VERB
eurjchem-2103	11	43	the	the	DET
eurjchem-2103	11	44	individual	individual	ADJ
eurjchem-2103	11	45	structural	structural	ADJ
eurjchem-2103	11	46	differences	difference	NOUN
eurjchem-2103	11	47	observed	observe	VERB
eurjchem-2103	11	48	among	among	ADP
eurjchem-2103	11	49	the	the	DET
eurjchem-2103	11	50	three	three	NUM
eurjchem-2103	11	51	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	11	52	and	and	CCONJ
eurjchem-2103	11	53	bsa	bsa	NOUN
eurjchem-2103	11	54	.	.	PUNCT
eurjchem-2103	12	1	there	there	PRON
eurjchem-2103	12	2	is	be	VERB
eurjchem-2103	12	3	a	a	DET
eurjchem-2103	12	4	descriptive	descriptive	ADJ
eurjchem-2103	12	5	protagonism	protagonism	NOUN
eurjchem-2103	12	6	of	of	ADP
eurjchem-2103	12	7	carboxyl	carboxyl	NOUN
eurjchem-2103	12	8	group	group	NOUN
eurjchem-2103	12	9	on	on	ADP
eurjchem-2103	12	10	the	the	DET
eurjchem-2103	12	11	enr	enr	PROPN
eurjchem-2103	12	12	interaction	interaction	NOUN
eurjchem-2103	12	13	which	which	PRON
eurjchem-2103	12	14	traps	trap	VERB
eurjchem-2103	12	15	the	the	DET
eurjchem-2103	12	16	molecule	molecule	NOUN
eurjchem-2103	12	17	and	and	CCONJ
eurjchem-2103	12	18	avoids	avoid	VERB
eurjchem-2103	12	19	the	the	DET
eurjchem-2103	12	20	deep	deep	ADJ
eurjchem-2103	12	21	communication	communication	NOUN
eurjchem-2103	12	22	in	in	ADP
eurjchem-2103	12	23	the	the	DET
eurjchem-2103	12	24	protein	protein	NOUN
eurjchem-2103	12	25	binding	bind	VERB
eurjchem-2103	12	26	pocket	pocket	NOUN
eurjchem-2103	12	27	,	,	PUNCT
eurjchem-2103	12	28	as	as	ADV
eurjchem-2103	12	29	well	well	ADV
eurjchem-2103	12	30	as	as	ADP
eurjchem-2103	12	31	the	the	DET
eurjchem-2103	12	32	ligands	ligand	NOUN
eurjchem-2103	12	33	cip	cip	NOUN
eurjchem-2103	12	34	and	and	CCONJ
eurjchem-2103	12	35	pef	pef	NOUN
eurjchem-2103	12	36	showed	show	VERB
eurjchem-2103	12	37	an	an	DET
eurjchem-2103	12	38	interface	interface	NOUN
eurjchem-2103	12	39	amino	amino	NOUN
eurjchem-2103	12	40	acid	acid	NOUN
eurjchem-2103	12	41	residue	residue	NOUN
eurjchem-2103	12	42	interaction	interaction	NOUN
eurjchem-2103	12	43	profile	profile	NOUN
eurjchem-2103	12	44	higher	high	ADJ
eurjchem-2103	12	45	than	than	ADP
eurjchem-2103	12	46	70	70	NUM
eurjchem-2103	12	47	%	%	NOUN
eurjchem-2103	12	48	.	.	PUNCT
eurjchem-2103	13	1	pefloxacin	pefloxacin	PROPN
eurjchem-2103	13	2	enrofloxacin	enrofloxacin	PROPN
eurjchem-2103	13	3	ciprofloxacin	ciprofloxacin	PROPN
eurjchem-2103	13	4	molecular	molecular	ADJ
eurjchem-2103	13	5	docking	docking	NOUN
eurjchem-2103	13	6	veterinary	veterinary	ADJ
eurjchem-2103	13	7	science	science	NOUN
eurjchem-2103	13	8	bovine	bovine	NOUN
eurjchem-2103	13	9	serum	serum	NOUN
eurjchem-2103	13	10	albumin	albumin	PROPN
eurjchem-2103	13	11	cite	cite	VERB
eurjchem-2103	13	12	this	this	PRON
eurjchem-2103	13	13	:	:	PUNCT
eurjchem-2103	13	14	eur	eur	PROPN
eurjchem-2103	13	15	.	.	PUNCT
eurjchem-2103	14	1	j.	j.	PROPN
eurjchem-2103	14	2	chem	chem	PROPN
eurjchem-2103	14	3	.	.	PUNCT
eurjchem-2103	15	1	2021	2021	NUM
eurjchem-2103	15	2	,	,	PUNCT
eurjchem-2103	15	3	12(2	12(2	NUM
eurjchem-2103	15	4	)	)	PUNCT
eurjchem-2103	15	5	,	,	PUNCT
eurjchem-2103	15	6	192	192	NUM
eurjchem-2103	15	7	-	-	SYM
eurjchem-2103	15	8	196	196	NUM
eurjchem-2103	15	9	journal	journal	NOUN
eurjchem-2103	15	10	website	website	NOUN
eurjchem-2103	15	11	:	:	PUNCT
eurjchem-2103	15	12	www.eurjchem.com	www.eurjchem.com	X
eurjchem-2103	15	13	1	1	X
eurjchem-2103	15	14	.	.	X
eurjchem-2103	15	15	introduction	introduction	NOUN
eurjchem-2103	15	16	the	the	DET
eurjchem-2103	15	17	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	15	18	are	be	AUX
eurjchem-2103	15	19	a	a	DET
eurjchem-2103	15	20	drug	drug	NOUN
eurjchem-2103	15	21	class	class	NOUN
eurjchem-2103	15	22	that	that	PRON
eurjchem-2103	15	23	targets	target	VERB
eurjchem-2103	15	24	the	the	DET
eurjchem-2103	15	25	bacterial	bacterial	ADJ
eurjchem-2103	15	26	dna	dna	NOUN
eurjchem-2103	15	27	gyrase	gyrase	NOUN
eurjchem-2103	15	28	and	and	CCONJ
eurjchem-2103	15	29	topoisomerase	topoisomerase	NOUN
eurjchem-2103	15	30	iv	iv	NUM
eurjchem-2103	15	31	varying	vary	VERB
eurjchem-2103	15	32	the	the	DET
eurjchem-2103	15	33	efficiency	efficiency	NOUN
eurjchem-2103	15	34	between	between	ADP
eurjchem-2103	15	35	low	low	ADJ
eurjchem-2103	15	36	and	and	CCONJ
eurjchem-2103	15	37	high	high	ADJ
eurjchem-2103	15	38	concentrations	concentration	NOUN
eurjchem-2103	15	39	[	[	X
eurjchem-2103	15	40	1	1	NUM
eurjchem-2103	15	41	]	]	PUNCT
eurjchem-2103	15	42	.	.	PUNCT
eurjchem-2103	16	1	the	the	DET
eurjchem-2103	16	2	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	16	3	are	be	AUX
eurjchem-2103	16	4	extensively	extensively	ADV
eurjchem-2103	16	5	used	use	VERB
eurjchem-2103	16	6	for	for	ADP
eurjchem-2103	16	7	the	the	DET
eurjchem-2103	16	8	treatment	treatment	NOUN
eurjchem-2103	16	9	of	of	ADP
eurjchem-2103	16	10	sick	sick	ADJ
eurjchem-2103	16	11	animals	animal	NOUN
eurjchem-2103	16	12	by	by	ADP
eurjchem-2103	16	13	bacteria	bacteria	NOUN
eurjchem-2103	16	14	,	,	PUNCT
eurjchem-2103	16	15	whether	whether	SCONJ
eurjchem-2103	16	16	in	in	ADP
eurjchem-2103	16	17	the	the	DET
eurjchem-2103	16	18	rapid	rapid	ADJ
eurjchem-2103	16	19	growth	growth	NOUN
eurjchem-2103	16	20	or	or	CCONJ
eurjchem-2103	16	21	stationary	stationary	ADJ
eurjchem-2103	16	22	microorganism	microorganism	NOUN
eurjchem-2103	16	23	phase	phase	NOUN
eurjchem-2103	16	24	[	[	X
eurjchem-2103	16	25	2	2	NUM
eurjchem-2103	16	26	]	]	PUNCT
eurjchem-2103	16	27	.	.	PUNCT
eurjchem-2103	17	1	due	due	ADP
eurjchem-2103	17	2	to	to	ADP
eurjchem-2103	17	3	the	the	DET
eurjchem-2103	17	4	uncontrolled	uncontrolled	ADJ
eurjchem-2103	17	5	used	use	VERB
eurjchem-2103	17	6	of	of	ADP
eurjchem-2103	17	7	some	some	DET
eurjchem-2103	17	8	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	17	9	,	,	PUNCT
eurjchem-2103	17	10	not	not	PART
eurjchem-2103	17	11	only	only	ADV
eurjchem-2103	17	12	as	as	ADP
eurjchem-2103	17	13	antibacterial	antibacterial	ADJ
eurjchem-2103	17	14	agents	agent	NOUN
eurjchem-2103	17	15	but	but	CCONJ
eurjchem-2103	17	16	also	also	ADV
eurjchem-2103	17	17	as	as	ADP
eurjchem-2103	17	18	growth	growth	NOUN
eurjchem-2103	17	19	promoters	promoter	NOUN
eurjchem-2103	17	20	and	and	CCONJ
eurjchem-2103	17	21	prophylactic	prophylactic	ADJ
eurjchem-2103	17	22	agents	agent	NOUN
eurjchem-2103	17	23	in	in	ADP
eurjchem-2103	17	24	lactating	lactate	VERB
eurjchem-2103	17	25	animals	animal	NOUN
eurjchem-2103	17	26	,	,	PUNCT
eurjchem-2103	17	27	it	it	PRON
eurjchem-2103	17	28	has	have	AUX
eurjchem-2103	17	29	been	be	AUX
eurjchem-2103	17	30	detecting	detect	VERB
eurjchem-2103	17	31	the	the	DET
eurjchem-2103	17	32	presence	presence	NOUN
eurjchem-2103	17	33	of	of	ADP
eurjchem-2103	17	34	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	17	35	in	in	ADP
eurjchem-2103	17	36	commercial	commercial	ADJ
eurjchem-2103	17	37	milk	milk	NOUN
eurjchem-2103	17	38	,	,	PUNCT
eurjchem-2103	17	39	being	be	AUX
eurjchem-2103	17	40	a	a	DET
eurjchem-2103	17	41	problem	problem	NOUN
eurjchem-2103	17	42	for	for	ADP
eurjchem-2103	17	43	human	human	ADJ
eurjchem-2103	17	44	health	health	NOUN
eurjchem-2103	18	1	[	[	X
eurjchem-2103	18	2	3	3	NUM
eurjchem-2103	18	3	-	-	SYM
eurjchem-2103	18	4	5	5	NUM
eurjchem-2103	18	5	]	]	PUNCT
eurjchem-2103	18	6	.	.	PUNCT
eurjchem-2103	19	1	the	the	DET
eurjchem-2103	19	2	ciprofloxacin	ciprofloxacin	NOUN
eurjchem-2103	19	3	(	(	PUNCT
eurjchem-2103	19	4	1	1	NUM
eurjchem-2103	19	5	-	-	PUNCT
eurjchem-2103	19	6	cyclopropyl-6	cyclopropyl-6	NUM
eurjchem-2103	19	7	-	-	PUNCT
eurjchem-2103	19	8	fluoro-4	fluoro-4	NOUN
eurjchem-2103	19	9	-	-	PUNCT
eurjchem-2103	19	10	oxo-7-(piperazin-1	oxo-7-(piperazin-1	NOUN
eurjchem-2103	19	11	-	-	PUNCT
eurjchem-2103	19	12	yl	yl	NOUN
eurjchem-2103	19	13	)	)	PUNCT
eurjchem-2103	19	14	-1,4	-1,4	ADV
eurjchem-2103	19	15	-	-	PUNCT
eurjchem-2103	19	16	dihydroquinoline-3	dihydroquinoline-3	VERB
eurjchem-2103	19	17	-	-	ADJ
eurjchem-2103	19	18	carboxylic	carboxylic	ADJ
eurjchem-2103	19	19	acid	acid	NOUN
eurjchem-2103	19	20	,	,	PUNCT
eurjchem-2103	19	21	figure	figure	NOUN
eurjchem-2103	19	22	1a	1a	NOUN
eurjchem-2103	19	23	)	)	PUNCT
eurjchem-2103	19	24	,	,	PUNCT
eurjchem-2103	19	25	enrofloxacin	enrofloxacin	PROPN
eurjchem-2103	19	26	(	(	PUNCT
eurjchem-2103	19	27	1	1	NUM
eurjchem-2103	19	28	-	-	PUNCT
eurjchem-2103	19	29	cyclopropyl-7-(4	cyclopropyl-7-(4	NOUN
eurjchem-2103	19	30	-	-	PUNCT
eurjchem-2103	19	31	ethylpiperazin-1	ethylpiperazin-1	NUM
eurjchem-2103	19	32	-	-	PUNCT
eurjchem-2103	19	33	yl)-6	yl)-6	NOUN
eurjchem-2103	19	34	-	-	PUNCT
eurjchem-2103	19	35	fluoro-4	fluoro-4	NOUN
eurjchem-2103	19	36	-	-	PUNCT
eurjchem-2103	19	37	oxo1,4	oxo1,4	ADV
eurjchem-2103	19	38	-	-	PUNCT
eurjchem-2103	19	39	dihydroquinoline-3	dihydroquinoline-3	VERB
eurjchem-2103	19	40	-	-	ADJ
eurjchem-2103	19	41	carboxylic	carboxylic	ADJ
eurjchem-2103	19	42	acid	acid	NOUN
eurjchem-2103	19	43	,	,	PUNCT
eurjchem-2103	19	44	figure	figure	NOUN
eurjchem-2103	19	45	1b	1b	NUM
eurjchem-2103	19	46	)	)	PUNCT
eurjchem-2103	19	47	and	and	CCONJ
eurjchem-2103	19	48	pefloxacin	pefloxacin	NOUN
eurjchem-2103	19	49	(	(	PUNCT
eurjchem-2103	19	50	1	1	NUM
eurjchem-2103	19	51	-	-	PUNCT
eurjchem-2103	19	52	ethyl-6	ethyl-6	NUM
eurjchem-2103	19	53	-	-	PUNCT
eurjchem-2103	19	54	fluoro-7-(4	fluoro-7-(4	ADJ
eurjchem-2103	19	55	-	-	PUNCT
eurjchem-2103	19	56	methylpiperazin-1	methylpiperazin-1	ADV
eurjchem-2103	19	57	-	-	PUNCT
eurjchem-2103	19	58	yl)-4	yl)-4	VERB
eurjchem-2103	19	59	-	-	PUNCT
eurjchem-2103	19	60	oxo-1,4dihydroquinoline-3	oxo-1,4dihydroquinoline-3	ADJ
eurjchem-2103	19	61	-	-	PUNCT
eurjchem-2103	19	62	carboxylic	carboxylic	ADJ
eurjchem-2103	19	63	acid	acid	NOUN
eurjchem-2103	19	64	,	,	PUNCT
eurjchem-2103	19	65	figure	figure	NOUN
eurjchem-2103	19	66	1c	1c	NOUN
eurjchem-2103	19	67	)	)	PUNCT
eurjchem-2103	19	68	are	be	AUX
eurjchem-2103	19	69	one	one	NUM
eurjchem-2103	19	70	of	of	ADP
eurjchem-2103	19	71	the	the	DET
eurjchem-2103	19	72	most	most	ADV
eurjchem-2103	19	73	common	common	ADJ
eurjchem-2103	19	74	synthetic	synthetic	ADJ
eurjchem-2103	19	75	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	19	76	widely	widely	ADV
eurjchem-2103	19	77	used	use	VERB
eurjchem-2103	19	78	as	as	ADP
eurjchem-2103	19	79	antimicrobial	antimicrobial	ADJ
eurjchem-2103	19	80	agents	agent	NOUN
eurjchem-2103	19	81	[	[	X
eurjchem-2103	19	82	6	6	NUM
eurjchem-2103	19	83	]	]	PUNCT
eurjchem-2103	19	84	.	.	PUNCT
eurjchem-2103	20	1	the	the	DET
eurjchem-2103	20	2	cip	cip	NOUN
eurjchem-2103	20	3	,	,	PUNCT
eurjchem-2103	20	4	enr	enr	PROPN
eurjchem-2103	20	5	,	,	PUNCT
eurjchem-2103	20	6	and	and	CCONJ
eurjchem-2103	20	7	pef	pef	NOUN
eurjchem-2103	20	8	are	be	AUX
eurjchem-2103	20	9	characterized	characterize	VERB
eurjchem-2103	20	10	by	by	ADP
eurjchem-2103	20	11	two	two	NUM
eurjchem-2103	20	12	pka	pka	PROPN
eurjchem-2103	20	13	values	value	NOUN
eurjchem-2103	20	14	,	,	PUNCT
eurjchem-2103	20	15	e.g.	e.g.	ADV
eurjchem-2103	20	16	,	,	PUNCT
eurjchem-2103	20	17	pk1	pk1	PROPN
eurjchem-2103	20	18	=	=	PUNCT
eurjchem-2103	20	19	6.16	6.16	NUM
eurjchem-2103	20	20	and	and	CCONJ
eurjchem-2103	20	21	pk2	pk2	PROPN
eurjchem-2103	20	22	=	=	PROPN
eurjchem-2103	20	23	8.63	8.63	NUM
eurjchem-2103	20	24	for	for	ADP
eurjchem-2103	20	25	cip	cip	NOUN
eurjchem-2103	21	1	[	[	X
eurjchem-2103	21	2	7	7	NUM
eurjchem-2103	21	3	]	]	PUNCT
eurjchem-2103	21	4	,	,	PUNCT
eurjchem-2103	21	5	pk1	pk1	NOUN
eurjchem-2103	21	6	=	=	PUNCT
eurjchem-2103	21	7	6.00	6.00	NUM
eurjchem-2103	21	8	and	and	CCONJ
eurjchem-2103	21	9	pk2	pk2	PROPN
eurjchem-2103	21	10	=	=	PROPN
eurjchem-2103	21	11	8.72	8.72	NUM
eurjchem-2103	21	12	for	for	ADP
eurjchem-2103	21	13	enr	enr	PROPN
eurjchem-2103	22	1	[	[	X
eurjchem-2103	22	2	8	8	NUM
eurjchem-2103	22	3	]	]	PUNCT
eurjchem-2103	22	4	and	and	CCONJ
eurjchem-2103	22	5	pk1	pk1	PROPN
eurjchem-2103	22	6	=	=	PROPN
eurjchem-2103	22	7	6.30	6.30	NUM
eurjchem-2103	22	8	and	and	CCONJ
eurjchem-2103	22	9	pk2	pk2	PROPN
eurjchem-2103	22	10	=	=	PROPN
eurjchem-2103	22	11	7.60	7.60	NUM
eurjchem-2103	22	12	for	for	ADP
eurjchem-2103	22	13	pef	pef	NOUN
eurjchem-2103	22	14	[	[	X
eurjchem-2103	22	15	9	9	NUM
eurjchem-2103	22	16	]	]	PUNCT
eurjchem-2103	22	17	,	,	PUNCT
eurjchem-2103	22	18	showing	show	VERB
eurjchem-2103	22	19	their	their	PRON
eurjchem-2103	22	20	internal	internal	ADJ
eurjchem-2103	22	21	versatile	versatile	ADJ
eurjchem-2103	22	22	structural	structural	ADJ
eurjchem-2103	22	23	change	change	NOUN
eurjchem-2103	22	24	according	accord	VERB
eurjchem-2103	22	25	to	to	ADP
eurjchem-2103	22	26	the	the	DET
eurjchem-2103	22	27	ph	ph	NOUN
eurjchem-2103	22	28	of	of	ADP
eurjchem-2103	22	29	the	the	DET
eurjchem-2103	22	30	different	different	ADJ
eurjchem-2103	22	31	biological	biological	ADJ
eurjchem-2103	22	32	medium	medium	NOUN
eurjchem-2103	22	33	.	.	PUNCT
eurjchem-2103	23	1	in	in	ADP
eurjchem-2103	23	2	terms	term	NOUN
eurjchem-2103	23	3	of	of	ADP
eurjchem-2103	23	4	infections	infection	NOUN
eurjchem-2103	23	5	in	in	ADP
eurjchem-2103	23	6	the	the	DET
eurjchem-2103	23	7	respiratory	respiratory	ADJ
eurjchem-2103	23	8	and	and	CCONJ
eurjchem-2103	23	9	alimentary	alimentary	ADJ
eurjchem-2103	23	10	tracts	tract	NOUN
eurjchem-2103	23	11	,	,	PUNCT
eurjchem-2103	23	12	generally	generally	ADV
eurjchem-2103	23	13	the	the	DET
eurjchem-2103	23	14	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	23	15	are	be	AUX
eurjchem-2103	23	16	administered	administer	VERB
eurjchem-2103	23	17	in	in	ADP
eurjchem-2103	23	18	veterinary	veterinary	ADJ
eurjchem-2103	23	19	medicine	medicine	NOUN
eurjchem-2103	23	20	via	via	ADP
eurjchem-2103	23	21	subcutaneous	subcutaneous	ADJ
eurjchem-2103	23	22	in	in	ADP
eurjchem-2103	23	23	cattle	cattle	NOUN
eurjchem-2103	23	24	,	,	PUNCT
eurjchem-2103	23	25	or	or	CCONJ
eurjchem-2103	23	26	even	even	ADV
eurjchem-2103	23	27	intramuscular	intramuscular	ADJ
eurjchem-2103	23	28	administration	administration	NOUN
eurjchem-2103	23	29	to	to	ADP
eurjchem-2103	23	30	pigs	pig	NOUN
eurjchem-2103	23	31	and	and	CCONJ
eurjchem-2103	23	32	orally	orally	ADV
eurjchem-2103	23	33	to	to	ADP
eurjchem-2103	23	34	turkeys	turkey	NOUN
eurjchem-2103	23	35	and	and	CCONJ
eurjchem-2103	23	36	chickens	chicken	NOUN
eurjchem-2103	24	1	[	[	X
eurjchem-2103	24	2	10	10	NUM
eurjchem-2103	24	3	]	]	PUNCT
eurjchem-2103	24	4	.	.	PUNCT
eurjchem-2103	25	1	particularly	particularly	ADV
eurjchem-2103	25	2	,	,	PUNCT
eurjchem-2103	25	3	the	the	DET
eurjchem-2103	25	4	enr	enr	PROPN
eurjchem-2103	25	5	injection	injection	NOUN
eurjchem-2103	25	6	is	be	AUX
eurjchem-2103	25	7	the	the	DET
eurjchem-2103	25	8	main	main	ADJ
eurjchem-2103	25	9	veterinary	veterinary	ADJ
eurjchem-2103	25	10	conduct	conduct	NOUN
eurjchem-2103	25	11	for	for	ADP
eurjchem-2103	25	12	use	use	NOUN
eurjchem-2103	25	13	in	in	ADP
eurjchem-2103	25	14	the	the	DET
eurjchem-2103	25	15	treatment	treatment	NOUN
eurjchem-2103	25	16	of	of	ADP
eurjchem-2103	25	17	bovine	bovine	ADJ
eurjchem-2103	25	18	respiratory	respiratory	ADJ
eurjchem-2103	25	19	illness	illness	NOUN
eurjchem-2103	25	20	caused	cause	VERB
eurjchem-2103	25	21	by	by	ADP
eurjchem-2103	25	22	susceptible	susceptible	ADJ
eurjchem-2103	25	23	microorganisms	microorganism	NOUN
eurjchem-2103	25	24	,	,	PUNCT
eurjchem-2103	25	25	including	include	VERB
eurjchem-2103	25	26	mannheimia	mannheimia	NOUN
eurjchem-2103	25	27	(	(	PUNCT
eurjchem-2103	25	28	pasteurella	pasteurella	NOUN
eurjchem-2103	25	29	)	)	PUNCT
eurjchem-2103	25	30	haemolytica	haemolytica	NOUN
eurjchem-2103	25	31	,	,	PUNCT
eurjchem-2103	25	32	histophilus	histophilus	ADJ
eurjchem-2103	25	33	somni	somni	NOUN
eurjchem-2103	25	34	and	and	CCONJ
eurjchem-2103	25	35	pasteurella	pasteurella	PROPN
eurjchem-2103	25	36	multocida	multocida	PROPN
eurjchem-2103	26	1	[	[	X
eurjchem-2103	26	2	11,12	11,12	NOUN
eurjchem-2103	26	3	]	]	PUNCT
eurjchem-2103	26	4	.	.	PUNCT
eurjchem-2103	27	1	alternatively	alternatively	ADV
eurjchem-2103	27	2	,	,	PUNCT
eurjchem-2103	27	3	the	the	DET
eurjchem-2103	27	4	available	available	ADJ
eurjchem-2103	27	5	biological	biological	ADJ
eurjchem-2103	27	6	assay	assay	PROPN
eurjchem-2103	27	7	data	datum	NOUN
eurjchem-2103	27	8	of	of	ADP
eurjchem-2103	27	9	cip	cip	NOUN
eurjchem-2103	27	10	for	for	ADP
eurjchem-2103	27	11	the	the	DET
eurjchem-2103	27	12	treatment	treatment	NOUN
eurjchem-2103	27	13	of	of	ADP
eurjchem-2103	27	14	acute	acute	ADJ
eurjchem-2103	27	15	mastitis	mastitis	NOUN
eurjchem-2103	27	16	in	in	ADP
eurjchem-2103	27	17	dairy	dairy	NOUN
eurjchem-2103	27	18	cows	cow	NOUN
eurjchem-2103	27	19	showed	show	VERB
eurjchem-2103	27	20	a	a	DET
eurjchem-2103	27	21	rate	rate	NOUN
eurjchem-2103	27	22	of	of	ADP
eurjchem-2103	27	23	86.0	86.0	NUM
eurjchem-2103	27	24	%	%	NOUN
eurjchem-2103	27	25	of	of	ADP
eurjchem-2103	27	26	success	success	NOUN
eurjchem-2103	27	27	,	,	PUNCT
eurjchem-2103	27	28	compared	compare	VERB
eurjchem-2103	27	29	with	with	ADP
eurjchem-2103	27	30	72.0	72.0	NUM
eurjchem-2103	27	31	%	%	NOUN
eurjchem-2103	27	32	of	of	ADP
eurjchem-2103	27	33	the	the	DET
eurjchem-2103	27	34	control	control	NOUN
eurjchem-2103	27	35	penicillin	penicillin	NOUN
eurjchem-2103	27	36	-	-	PUNCT
eurjchem-2103	27	37	streptomycin	streptomycin	PROPN
eurjchem-2103	27	38	[	[	X
eurjchem-2103	27	39	13	13	NUM
eurjchem-2103	27	40	]	]	PUNCT
eurjchem-2103	27	41	.	.	PUNCT
eurjchem-2103	28	1	in	in	ADP
eurjchem-2103	28	2	its	its	PRON
eurjchem-2103	28	3	turn	turn	NOUN
eurjchem-2103	28	4	,	,	PUNCT
eurjchem-2103	28	5	the	the	DET
eurjchem-2103	28	6	pef	pef	NOUN
eurjchem-2103	28	7	performance	performance	NOUN
eurjchem-2103	28	8	showed	show	VERB
eurjchem-2103	28	9	substantial	substantial	ADJ
eurjchem-2103	28	10	activity	activity	NOUN
eurjchem-2103	28	11	against	against	ADP
eurjchem-2103	28	12	gramnegative	gramnegative	ADJ
eurjchem-2103	28	13	bacteria	bacteria	NOUN
eurjchem-2103	28	14	including	include	VERB
eurjchem-2103	28	15	aeromonas	aeromonas	PROPN
eurjchem-2103	28	16	hydrophila	hydrophila	PROPN
eurjchem-2103	28	17	,	,	PUNCT
eurjchem-2103	28	18	capnocytophaga	capnocytophaga	NOUN
eurjchem-2103	28	19	,	,	PUNCT
eurjchem-2103	28	20	haemophilus	haemophilus	X
eurjchem-2103	28	21	,	,	PUNCT
eurjchem-2103	28	22	neisseria	neisseria	NOUN
eurjchem-2103	28	23	,	,	PUNCT
eurjchem-2103	28	24	and	and	CCONJ
eurjchem-2103	28	25	legionella	legionella	NOUN
eurjchem-2103	28	26	,	,	PUNCT
eurjchem-2103	28	27	however	however	ADV
eurjchem-2103	28	28	,	,	PUNCT
eurjchem-2103	28	29	pef	pef	NOUN
eurjchem-2103	28	30	is	be	AUX
eurjchem-2103	28	31	less	less	ADV
eurjchem-2103	28	32	active	active	ADJ
eurjchem-2103	28	33	than	than	ADP
eurjchem-2103	28	34	cip	cip	NOUN
eurjchem-2103	28	35	towards	towards	ADP
eurjchem-2103	28	36	pseudomonas	pseudomona	NOUN
eurjchem-2103	28	37	aeruginosa	aeruginosa	NOUN
eurjchem-2103	29	1	[	[	X
eurjchem-2103	29	2	14	14	NUM
eurjchem-2103	29	3	]	]	PUNCT
eurjchem-2103	29	4	.	.	PUNCT
eurjchem-2103	30	1	in	in	ADP
eurjchem-2103	30	2	cattle	cattle	NOUN
eurjchem-2103	30	3	,	,	PUNCT
eurjchem-2103	30	4	has	have	AUX
eurjchem-2103	30	5	already	already	ADV
eurjchem-2103	30	6	been	be	AUX
eurjchem-2103	30	7	described	describe	VERB
eurjchem-2103	30	8	the	the	DET
eurjchem-2103	30	9	detection	detection	NOUN
eurjchem-2103	30	10	of	of	ADP
eurjchem-2103	30	11	enr	enr	PROPN
eurjchem-2103	30	12	+	+	CCONJ
eurjchem-2103	30	13	cip	cip	NOUN
eurjchem-2103	30	14	deposit	deposit	NOUN
eurjchem-2103	30	15	,	,	PUNCT
eurjchem-2103	30	16	being	be	AUX
eurjchem-2103	30	17	detected	detect	VERB
eurjchem-2103	30	18	in	in	ADP
eurjchem-2103	30	19	about	about	ADV
eurjchem-2103	30	20	65.0	65.0	NUM
eurjchem-2103	30	21	%	%	NOUN
eurjchem-2103	30	22	,	,	PUNCT
eurjchem-2103	30	23	80.0	80.0	NUM
eurjchem-2103	30	24	%	%	NOUN
eurjchem-2103	30	25	,	,	PUNCT
eurjchem-2103	30	26	88.0	88.0	NUM
eurjchem-2103	30	27	%	%	NOUN
eurjchem-2103	30	28	,	,	PUNCT
eurjchem-2103	30	29	and	and	CCONJ
eurjchem-2103	30	30	50.0	50.0	NUM
eurjchem-2103	30	31	%	%	NOUN
eurjchem-2103	30	32	in	in	ADP
eurjchem-2103	30	33	liver	liver	NOUN
eurjchem-2103	30	34	,	,	PUNCT
eurjchem-2103	30	35	kidney	kidney	NOUN
eurjchem-2103	30	36	,	,	PUNCT
eurjchem-2103	30	37	muscle	muscle	NOUN
eurjchem-2103	30	38	,	,	PUNCT
eurjchem-2103	30	39	and	and	CCONJ
eurjchem-2103	30	40	fat	fat	ADJ
eurjchem-2103	30	41	,	,	PUNCT
eurjchem-2103	30	42	respectively	respectively	ADV
eurjchem-2103	30	43	[	[	X
eurjchem-2103	30	44	5	5	NUM
eurjchem-2103	30	45	]	]	PUNCT
eurjchem-2103	30	46	.	.	PUNCT
eurjchem-2103	31	1	abstract	abstract	ADJ
eurjchem-2103	31	2	research	research	NOUN
eurjchem-2103	31	3	article	article	NOUN
eurjchem-2103	31	4	keywords	keyword	VERB
eurjchem-2103	31	5	https://dx.doi.org/10.5155/eurjchem.12.2.192-196.2103	https://dx.doi.org/10.5155/eurjchem.12.2.192-196.2103	NOUN
eurjchem-2103	31	6	https://www.eurjchem.com/	https://www.eurjchem.com/	VERB
eurjchem-2103	31	7	https://dx.doi.org/10.5155/eurjchem.12.2.192-196.2103	https://dx.doi.org/10.5155/eurjchem.12.2.192-196.2103	PROPN
eurjchem-2103	31	8	mailto:otavio.chaves@ioc.fiocruz.br	mailto:otavio.chaves@ioc.fiocruz.br	ADJ
eurjchem-2103	31	9	mailto:leonardo_vazquez@hotmail.com	mailto:leonardo_vazquez@hotmail.com	X
eurjchem-2103	31	10	mailto:otavio.chaves@ioc.fiocruz.br	mailto:otavio.chaves@ioc.fiocruz.br	PROPN
eurjchem-2103	31	11	http://www.eurjchem.com/	http://www.eurjchem.com/	PROPN
eurjchem-2103	31	12	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.12.2.192-196.2103&domain=pdf&date_stamp=2021-06-30	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.12.2.192-196.2103&domain=pdf&date_stamp=2021-06-30	PROPN
eurjchem-2103	31	13	chaves	chave	NOUN
eurjchem-2103	31	14	and	and	CCONJ
eurjchem-2103	31	15	vazquez	vazquez	PROPN
eurjchem-2103	31	16	/	/	SYM
eurjchem-2103	31	17	european	european	PROPN
eurjchem-2103	31	18	journal	journal	PROPN
eurjchem-2103	31	19	of	of	ADP
eurjchem-2103	31	20	chemistry	chemistry	NOUN
eurjchem-2103	31	21	12	12	NUM
eurjchem-2103	31	22	(	(	PUNCT
eurjchem-2103	31	23	2	2	NUM
eurjchem-2103	31	24	)	)	PUNCT
eurjchem-2103	31	25	(	(	PUNCT
eurjchem-2103	31	26	2021	2021	NUM
eurjchem-2103	31	27	)	)	PUNCT
eurjchem-2103	31	28	192	192	NUM
eurjchem-2103	31	29	-	-	SYM
eurjchem-2103	31	30	196	196	NUM
eurjchem-2103	31	31	193	193	NUM
eurjchem-2103	31	32	2021	2021	NUM
eurjchem-2103	31	33	–	–	PUNCT
eurjchem-2103	31	34	european	european	ADJ
eurjchem-2103	31	35	journal	journal	NOUN
eurjchem-2103	31	36	of	of	ADP
eurjchem-2103	31	37	chemistry	chemistry	NOUN
eurjchem-2103	31	38	–	–	PUNCT
eurjchem-2103	31	39	cc	cc	NOUN
eurjchem-2103	31	40	by	by	ADP
eurjchem-2103	31	41	nc	nc	PROPN
eurjchem-2103	31	42	–	–	PUNCT
eurjchem-2103	31	43	doi	doi	NOUN
eurjchem-2103	31	44	:	:	PUNCT
eurjchem-2103	31	45	10.5155	10.5155	NUM
eurjchem-2103	31	46	/	/	SYM
eurjchem-2103	31	47	eurjchem.12.2.192	eurjchem.12.2.192	NOUN
eurjchem-2103	31	48	-	-	PUNCT
eurjchem-2103	31	49	196.2103	196.2103	NUM
eurjchem-2103	31	50	figure	figure	NOUN
eurjchem-2103	31	51	1	1	NUM
eurjchem-2103	31	52	.	.	PUNCT
eurjchem-2103	32	1	the	the	DET
eurjchem-2103	32	2	chemical	chemical	ADJ
eurjchem-2103	32	3	structure	structure	NOUN
eurjchem-2103	32	4	of	of	ADP
eurjchem-2103	32	5	the	the	DET
eurjchem-2103	32	6	three	three	NUM
eurjchem-2103	32	7	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	32	8	under	under	ADP
eurjchem-2103	32	9	study	study	NOUN
eurjchem-2103	32	10	:	:	PUNCT
eurjchem-2103	32	11	ciprofloxacin	ciprofloxacin	PROPN
eurjchem-2103	32	12	(	(	PUNCT
eurjchem-2103	32	13	cip	cip	PROPN
eurjchem-2103	32	14	)	)	PUNCT
eurjchem-2103	32	15	,	,	PUNCT
eurjchem-2103	32	16	enrofloxacin	enrofloxacin	PROPN
eurjchem-2103	32	17	(	(	PUNCT
eurjchem-2103	32	18	enr	enr	PROPN
eurjchem-2103	32	19	)	)	PUNCT
eurjchem-2103	32	20	,	,	PUNCT
eurjchem-2103	32	21	and	and	CCONJ
eurjchem-2103	32	22	pefloxacin	pefloxacin	PROPN
eurjchem-2103	32	23	(	(	PUNCT
eurjchem-2103	32	24	pef	pef	NOUN
eurjchem-2103	32	25	)	)	PUNCT
eurjchem-2103	32	26	.	.	PUNCT
eurjchem-2103	33	1	the	the	DET
eurjchem-2103	33	2	pharmacokinetics	pharmacokinetic	NOUN
eurjchem-2103	33	3	of	of	ADP
eurjchem-2103	33	4	this	this	DET
eurjchem-2103	33	5	class	class	NOUN
eurjchem-2103	33	6	is	be	AUX
eurjchem-2103	33	7	mainly	mainly	ADV
eurjchem-2103	33	8	driven	drive	VERB
eurjchem-2103	33	9	by	by	ADP
eurjchem-2103	33	10	serum	serum	NOUN
eurjchem-2103	33	11	albumin	albumin	NOUN
eurjchem-2103	33	12	(	(	PUNCT
eurjchem-2103	33	13	sa	sa	PROPN
eurjchem-2103	33	14	)	)	PUNCT
eurjchem-2103	33	15	,	,	PUNCT
eurjchem-2103	33	16	which	which	PRON
eurjchem-2103	33	17	is	be	AUX
eurjchem-2103	33	18	the	the	DET
eurjchem-2103	33	19	most	most	ADV
eurjchem-2103	33	20	abundant	abundant	ADJ
eurjchem-2103	33	21	protein	protein	NOUN
eurjchem-2103	33	22	present	present	ADJ
eurjchem-2103	33	23	in	in	ADP
eurjchem-2103	33	24	the	the	DET
eurjchem-2103	33	25	circulatory	circulatory	ADJ
eurjchem-2103	33	26	system	system	NOUN
eurjchem-2103	33	27	,	,	PUNCT
eurjchem-2103	33	28	being	be	AUX
eurjchem-2103	33	29	about	about	ADV
eurjchem-2103	33	30	60	60	NUM
eurjchem-2103	33	31	%	%	NOUN
eurjchem-2103	33	32	of	of	ADP
eurjchem-2103	33	33	the	the	DET
eurjchem-2103	33	34	total	total	ADJ
eurjchem-2103	33	35	plasma	plasma	NOUN
eurjchem-2103	33	36	proteins	protein	NOUN
eurjchem-2103	33	37	[	[	X
eurjchem-2103	33	38	15	15	NUM
eurjchem-2103	33	39	]	]	PUNCT
eurjchem-2103	33	40	.	.	PUNCT
eurjchem-2103	34	1	its	its	PRON
eurjchem-2103	34	2	main	main	ADJ
eurjchem-2103	34	3	function	function	NOUN
eurjchem-2103	34	4	is	be	AUX
eurjchem-2103	34	5	associated	associate	VERB
eurjchem-2103	34	6	with	with	ADP
eurjchem-2103	34	7	the	the	DET
eurjchem-2103	34	8	distribution	distribution	NOUN
eurjchem-2103	34	9	and	and	CCONJ
eurjchem-2103	34	10	excretion	excretion	NOUN
eurjchem-2103	34	11	of	of	ADP
eurjchem-2103	34	12	several	several	ADJ
eurjchem-2103	34	13	endogenous	endogenous	ADJ
eurjchem-2103	34	14	and	and	CCONJ
eurjchem-2103	34	15	exogenous	exogenous	ADJ
eurjchem-2103	34	16	compounds	compound	NOUN
eurjchem-2103	34	17	,	,	PUNCT
eurjchem-2103	34	18	e.g.	e.g.	ADV
eurjchem-2103	34	19	,	,	PUNCT
eurjchem-2103	34	20	fatty	fatty	NOUN
eurjchem-2103	34	21	acids	acid	NOUN
eurjchem-2103	34	22	,	,	PUNCT
eurjchem-2103	34	23	bilirubin	bilirubin	NOUN
eurjchem-2103	34	24	,	,	PUNCT
eurjchem-2103	34	25	prostaglandins	prostaglandin	NOUN
eurjchem-2103	34	26	,	,	PUNCT
eurjchem-2103	34	27	steroids	steroid	NOUN
eurjchem-2103	34	28	,	,	PUNCT
eurjchem-2103	34	29	cholesterol	cholesterol	NOUN
eurjchem-2103	34	30	,	,	PUNCT
eurjchem-2103	34	31	hormones	hormone	NOUN
eurjchem-2103	34	32	,	,	PUNCT
eurjchem-2103	34	33	vitamins	vitamin	NOUN
eurjchem-2103	34	34	,	,	PUNCT
eurjchem-2103	34	35	and	and	CCONJ
eurjchem-2103	34	36	drugs	drug	NOUN
eurjchem-2103	34	37	[	[	X
eurjchem-2103	34	38	16	16	NUM
eurjchem-2103	34	39	]	]	PUNCT
eurjchem-2103	34	40	.	.	PUNCT
eurjchem-2103	35	1	in	in	ADP
eurjchem-2103	35	2	this	this	DET
eurjchem-2103	35	3	case	case	NOUN
eurjchem-2103	35	4	,	,	PUNCT
eurjchem-2103	35	5	bovine	bovine	NOUN
eurjchem-2103	35	6	serum	serum	NOUN
eurjchem-2103	35	7	albumin	albumin	PROPN
eurjchem-2103	35	8	(	(	PUNCT
eurjchem-2103	35	9	bsa	bsa	PROPN
eurjchem-2103	35	10	)	)	PUNCT
eurjchem-2103	35	11	is	be	AUX
eurjchem-2103	35	12	the	the	DET
eurjchem-2103	35	13	main	main	ADJ
eurjchem-2103	35	14	transporting	transporting	NOUN
eurjchem-2103	35	15	protein	protein	NOUN
eurjchem-2103	35	16	synthesized	synthesize	VERB
eurjchem-2103	35	17	in	in	ADP
eurjchem-2103	35	18	the	the	DET
eurjchem-2103	35	19	cattle	cattle	NOUN
eurjchem-2103	35	20	liver	liver	NOUN
eurjchem-2103	35	21	and	and	CCONJ
eurjchem-2103	35	22	also	also	ADV
eurjchem-2103	35	23	the	the	DET
eurjchem-2103	35	24	most	most	ADV
eurjchem-2103	35	25	representative	representative	ADJ
eurjchem-2103	35	26	globular	globular	ADJ
eurjchem-2103	35	27	protein	protein	NOUN
eurjchem-2103	35	28	for	for	ADP
eurjchem-2103	35	29	preliminary	preliminary	ADJ
eurjchem-2103	35	30	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-2103	35	31	studies	study	NOUN
eurjchem-2103	35	32	.	.	PUNCT
eurjchem-2103	36	1	[	[	X
eurjchem-2103	36	2	17	17	NUM
eurjchem-2103	36	3	]	]	PUNCT
eurjchem-2103	36	4	.	.	PUNCT
eurjchem-2103	37	1	from	from	ADP
eurjchem-2103	37	2	a	a	DET
eurjchem-2103	37	3	structural	structural	ADJ
eurjchem-2103	37	4	point	point	NOUN
eurjchem-2103	37	5	of	of	ADP
eurjchem-2103	37	6	view	view	NOUN
eurjchem-2103	37	7	,	,	PUNCT
eurjchem-2103	37	8	bsa	bsa	PROPN
eurjchem-2103	37	9	is	be	AUX
eurjchem-2103	37	10	a	a	DET
eurjchem-2103	37	11	single	single	ADJ
eurjchem-2103	37	12	-	-	PUNCT
eurjchem-2103	37	13	chain	chain	NOUN
eurjchem-2103	37	14	composed	compose	VERB
eurjchem-2103	37	15	of	of	ADP
eurjchem-2103	37	16	583	583	NUM
eurjchem-2103	37	17	amino	amino	NOUN
eurjchem-2103	37	18	acid	acid	NOUN
eurjchem-2103	37	19	residues	residue	NOUN
eurjchem-2103	37	20	,	,	PUNCT
eurjchem-2103	37	21	having	have	VERB
eurjchem-2103	37	22	20	20	NUM
eurjchem-2103	37	23	tyrosine	tyrosine	NOUN
eurjchem-2103	37	24	and	and	CCONJ
eurjchem-2103	37	25	2	2	NUM
eurjchem-2103	37	26	tryptophan	tryptophan	NOUN
eurjchem-2103	37	27	residues	residue	NOUN
eurjchem-2103	37	28	(	(	PUNCT
eurjchem-2103	37	29	trp-134	trp-134	NOUN
eurjchem-2103	37	30	and	and	CCONJ
eurjchem-2103	37	31	trp-212	trp-212	NOUN
eurjchem-2103	37	32	)	)	PUNCT
eurjchem-2103	37	33	which	which	PRON
eurjchem-2103	37	34	play	play	VERB
eurjchem-2103	37	35	an	an	DET
eurjchem-2103	37	36	important	important	ADJ
eurjchem-2103	37	37	role	role	NOUN
eurjchem-2103	37	38	in	in	ADP
eurjchem-2103	37	39	the	the	DET
eurjchem-2103	37	40	interaction	interaction	NOUN
eurjchem-2103	37	41	with	with	ADP
eurjchem-2103	37	42	endogenous	endogenous	ADJ
eurjchem-2103	37	43	and	and	CCONJ
eurjchem-2103	37	44	exogenous	exogenous	ADJ
eurjchem-2103	37	45	compounds	compound	NOUN
eurjchem-2103	37	46	.	.	PUNCT
eurjchem-2103	38	1	the	the	DET
eurjchem-2103	38	2	secondary	secondary	ADJ
eurjchem-2103	38	3	structure	structure	NOUN
eurjchem-2103	38	4	of	of	ADP
eurjchem-2103	38	5	bsa	bsa	PROPN
eurjchem-2103	38	6	consists	consist	VERB
eurjchem-2103	38	7	of	of	ADP
eurjchem-2103	38	8	nine	nine	NUM
eurjchem-2103	38	9	loops	loop	NOUN
eurjchem-2103	38	10	held	hold	VERB
eurjchem-2103	38	11	together	together	ADV
eurjchem-2103	38	12	by	by	ADP
eurjchem-2103	38	13	17	17	NUM
eurjchem-2103	38	14	disulfide	disulfide	NOUN
eurjchem-2103	38	15	bonds	bond	NOUN
eurjchem-2103	38	16	,	,	PUNCT
eurjchem-2103	38	17	resulting	result	VERB
eurjchem-2103	38	18	in	in	ADP
eurjchem-2103	38	19	tertiary	tertiary	ADJ
eurjchem-2103	38	20	structure	structure	NOUN
eurjchem-2103	38	21	of	of	ADP
eurjchem-2103	38	22	three	three	NUM
eurjchem-2103	38	23	domains	domain	NOUN
eurjchem-2103	38	24	(	(	PUNCT
eurjchem-2103	38	25	i	i	PROPN
eurjchem-2103	38	26	,	,	PUNCT
eurjchem-2103	38	27	ii	ii	PROPN
eurjchem-2103	38	28	,	,	PUNCT
eurjchem-2103	38	29	and	and	CCONJ
eurjchem-2103	38	30	iii	iii	X
eurjchem-2103	38	31	)	)	PUNCT
eurjchem-2103	38	32	separated	separate	VERB
eurjchem-2103	38	33	into	into	ADP
eurjchem-2103	38	34	two	two	NUM
eurjchem-2103	38	35	subdomains	subdomain	NOUN
eurjchem-2103	38	36	(	(	PUNCT
eurjchem-2103	38	37	a	a	PRON
eurjchem-2103	38	38	and	and	CCONJ
eurjchem-2103	38	39	b	b	NOUN
eurjchem-2103	38	40	)	)	PUNCT
eurjchem-2103	38	41	.	.	PUNCT
eurjchem-2103	39	1	these	these	DET
eurjchem-2103	39	2	disulfide	disulfide	NOUN
eurjchem-2103	39	3	bonds	bond	NOUN
eurjchem-2103	39	4	carry	carry	VERB
eurjchem-2103	39	5	a	a	DET
eurjchem-2103	39	6	rigidity	rigidity	NOUN
eurjchem-2103	39	7	to	to	ADP
eurjchem-2103	39	8	the	the	DET
eurjchem-2103	39	9	helices	helix	NOUN
eurjchem-2103	39	10	,	,	PUNCT
eurjchem-2103	39	11	but	but	CCONJ
eurjchem-2103	39	12	at	at	ADP
eurjchem-2103	39	13	the	the	DET
eurjchem-2103	39	14	same	same	ADJ
eurjchem-2103	39	15	time	time	NOUN
eurjchem-2103	39	16	allow	allow	VERB
eurjchem-2103	39	17	sufficient	sufficient	ADJ
eurjchem-2103	39	18	flexibility	flexibility	NOUN
eurjchem-2103	39	19	for	for	ADP
eurjchem-2103	39	20	the	the	DET
eurjchem-2103	39	21	protein	protein	NOUN
eurjchem-2103	39	22	to	to	PART
eurjchem-2103	39	23	suffer	suffer	VERB
eurjchem-2103	39	24	conformational	conformational	ADJ
eurjchem-2103	39	25	changes	change	NOUN
eurjchem-2103	39	26	based	base	VERB
eurjchem-2103	39	27	on	on	ADP
eurjchem-2103	39	28	the	the	DET
eurjchem-2103	39	29	experimental	experimental	ADJ
eurjchem-2103	39	30	conditions	condition	NOUN
eurjchem-2103	39	31	[	[	X
eurjchem-2103	39	32	6	6	NUM
eurjchem-2103	39	33	]	]	PUNCT
eurjchem-2103	39	34	.	.	PUNCT
eurjchem-2103	40	1	due	due	ADP
eurjchem-2103	40	2	to	to	ADP
eurjchem-2103	40	3	a	a	DET
eurjchem-2103	40	4	large	large	ADJ
eurjchem-2103	40	5	number	number	NOUN
eurjchem-2103	40	6	of	of	ADP
eurjchem-2103	40	7	negative	negative	ADJ
eurjchem-2103	40	8	charged	charge	VERB
eurjchem-2103	40	9	(	(	PUNCT
eurjchem-2103	40	10	glu	glu	NOUN
eurjchem-2103	40	11	and	and	CCONJ
eurjchem-2103	40	12	asp	asp	NOUN
eurjchem-2103	40	13	)	)	PUNCT
eurjchem-2103	40	14	and	and	CCONJ
eurjchem-2103	40	15	positively	positively	ADV
eurjchem-2103	40	16	charged	charge	VERB
eurjchem-2103	40	17	(	(	PUNCT
eurjchem-2103	40	18	lys	lys	NOUN
eurjchem-2103	40	19	and	and	CCONJ
eurjchem-2103	40	20	arg	arg	NOUN
eurjchem-2103	40	21	)	)	PUNCT
eurjchem-2103	40	22	residues	residue	NOUN
eurjchem-2103	40	23	,	,	PUNCT
eurjchem-2103	40	24	bsa	bsa	PROPN
eurjchem-2103	40	25	is	be	AUX
eurjchem-2103	40	26	highly	highly	ADV
eurjchem-2103	40	27	soluble	soluble	ADJ
eurjchem-2103	40	28	in	in	ADP
eurjchem-2103	40	29	aqueous	aqueous	ADJ
eurjchem-2103	40	30	media	medium	NOUN
eurjchem-2103	40	31	[	[	X
eurjchem-2103	40	32	17	17	NUM
eurjchem-2103	40	33	]	]	PUNCT
eurjchem-2103	40	34	.	.	PUNCT
eurjchem-2103	41	1	extensive	extensive	ADJ
eurjchem-2103	41	2	investigations	investigation	NOUN
eurjchem-2103	41	3	on	on	ADP
eurjchem-2103	41	4	the	the	DET
eurjchem-2103	41	5	interaction	interaction	NOUN
eurjchem-2103	41	6	between	between	ADP
eurjchem-2103	41	7	commercial	commercial	ADJ
eurjchem-2103	41	8	drugs	drug	NOUN
eurjchem-2103	41	9	with	with	ADP
eurjchem-2103	41	10	sa	sa	PROPN
eurjchem-2103	41	11	have	have	AUX
eurjchem-2103	41	12	been	be	AUX
eurjchem-2103	41	13	reported	report	VERB
eurjchem-2103	41	14	[	[	PUNCT
eurjchem-2103	41	15	18	18	NUM
eurjchem-2103	41	16	-	-	SYM
eurjchem-2103	41	17	20	20	NUM
eurjchem-2103	41	18	]	]	PUNCT
eurjchem-2103	41	19	.	.	PUNCT
eurjchem-2103	42	1	since	since	SCONJ
eurjchem-2103	42	2	sa	sa	PROPN
eurjchem-2103	42	3	assists	assist	NOUN
eurjchem-2103	42	4	as	as	ADP
eurjchem-2103	42	5	the	the	DET
eurjchem-2103	42	6	main	main	ADJ
eurjchem-2103	42	7	transport	transport	NOUN
eurjchem-2103	42	8	carrier	carrier	NOUN
eurjchem-2103	42	9	of	of	ADP
eurjchem-2103	42	10	drugs	drug	NOUN
eurjchem-2103	42	11	and	and	CCONJ
eurjchem-2103	42	12	plays	play	VERB
eurjchem-2103	42	13	a	a	DET
eurjchem-2103	42	14	prevailing	prevail	VERB
eurjchem-2103	42	15	role	role	NOUN
eurjchem-2103	42	16	on	on	ADP
eurjchem-2103	42	17	their	their	PRON
eurjchem-2103	42	18	bioavailability	bioavailability	NOUN
eurjchem-2103	42	19	,	,	PUNCT
eurjchem-2103	42	20	having	have	VERB
eurjchem-2103	42	21	a	a	DET
eurjchem-2103	42	22	significant	significant	ADJ
eurjchem-2103	42	23	impact	impact	NOUN
eurjchem-2103	42	24	on	on	ADP
eurjchem-2103	42	25	the	the	DET
eurjchem-2103	42	26	pharmacokinetics	pharmacokinetic	NOUN
eurjchem-2103	42	27	of	of	ADP
eurjchem-2103	42	28	drugs	drug	NOUN
eurjchem-2103	42	29	,	,	PUNCT
eurjchem-2103	42	30	the	the	DET
eurjchem-2103	42	31	profound	profound	ADJ
eurjchem-2103	42	32	study	study	NOUN
eurjchem-2103	42	33	of	of	ADP
eurjchem-2103	42	34	the	the	DET
eurjchem-2103	42	35	behavior	behavior	NOUN
eurjchem-2103	42	36	on	on	ADP
eurjchem-2103	42	37	the	the	DET
eurjchem-2103	42	38	relationship	relationship	NOUN
eurjchem-2103	42	39	between	between	ADP
eurjchem-2103	42	40	albumin	albumin	NOUN
eurjchem-2103	42	41	and	and	CCONJ
eurjchem-2103	42	42	drugs	drug	NOUN
eurjchem-2103	42	43	is	be	AUX
eurjchem-2103	42	44	particularly	particularly	ADV
eurjchem-2103	42	45	important	important	ADJ
eurjchem-2103	42	46	,	,	PUNCT
eurjchem-2103	42	47	affecting	affect	VERB
eurjchem-2103	42	48	the	the	DET
eurjchem-2103	42	49	effectiveness	effectiveness	NOUN
eurjchem-2103	42	50	of	of	ADP
eurjchem-2103	42	51	pharmaceutical	pharmaceutical	ADJ
eurjchem-2103	42	52	agents	agent	NOUN
eurjchem-2103	42	53	[	[	X
eurjchem-2103	42	54	21	21	NUM
eurjchem-2103	42	55	]	]	PUNCT
eurjchem-2103	42	56	.	.	PUNCT
eurjchem-2103	43	1	despite	despite	SCONJ
eurjchem-2103	43	2	the	the	DET
eurjchem-2103	43	3	numerous	numerous	ADJ
eurjchem-2103	43	4	reports	report	NOUN
eurjchem-2103	43	5	of	of	ADP
eurjchem-2103	43	6	the	the	DET
eurjchem-2103	43	7	therapeutic	therapeutic	ADJ
eurjchem-2103	43	8	importance	importance	NOUN
eurjchem-2103	43	9	of	of	ADP
eurjchem-2103	43	10	cip	cip	NOUN
eurjchem-2103	43	11	,	,	PUNCT
eurjchem-2103	43	12	enr	enr	PROPN
eurjchem-2103	43	13	,	,	PUNCT
eurjchem-2103	43	14	and	and	CCONJ
eurjchem-2103	43	15	pef	pef	NOUN
eurjchem-2103	43	16	on	on	ADP
eurjchem-2103	43	17	the	the	DET
eurjchem-2103	43	18	treatment	treatment	NOUN
eurjchem-2103	43	19	of	of	ADP
eurjchem-2103	43	20	diverse	diverse	ADJ
eurjchem-2103	43	21	animal	animal	NOUN
eurjchem-2103	43	22	illness	illness	NOUN
eurjchem-2103	43	23	,	,	PUNCT
eurjchem-2103	43	24	the	the	DET
eurjchem-2103	43	25	specialized	specialized	PROPN
eurjchem-2103	43	26	literature	literature	PROPN
eurjchem-2103	43	27	reports	report	VERB
eurjchem-2103	43	28	a	a	DET
eurjchem-2103	43	29	spectroscopic	spectroscopic	ADJ
eurjchem-2103	43	30	analysis	analysis	NOUN
eurjchem-2103	43	31	on	on	ADP
eurjchem-2103	43	32	the	the	DET
eurjchem-2103	43	33	understanding	understanding	NOUN
eurjchem-2103	43	34	of	of	ADP
eurjchem-2103	43	35	the	the	DET
eurjchem-2103	43	36	interactions	interaction	NOUN
eurjchem-2103	43	37	between	between	ADP
eurjchem-2103	43	38	albumin	albumin	NOUN
eurjchem-2103	43	39	:	:	PUNCT
eurjchem-2103	43	40	cip	cip	NOUN
eurjchem-2103	43	41	/	/	SYM
eurjchem-2103	43	42	enr	enr	PROPN
eurjchem-2103	43	43	/	/	SYM
eurjchem-2103	43	44	pef	pef	NOUN
eurjchem-2103	43	45	[	[	X
eurjchem-2103	43	46	6,22	6,22	NOUN
eurjchem-2103	43	47	-	-	PUNCT
eurjchem-2103	43	48	31	31	NUM
eurjchem-2103	43	49	]	]	PUNCT
eurjchem-2103	43	50	.	.	PUNCT
eurjchem-2103	44	1	in	in	ADP
eurjchem-2103	44	2	silico	silico	NOUN
eurjchem-2103	44	3	approach	approach	NOUN
eurjchem-2103	44	4	via	via	ADP
eurjchem-2103	44	5	molecular	molecular	ADJ
eurjchem-2103	44	6	docking	docking	NOUN
eurjchem-2103	44	7	calculations	calculation	NOUN
eurjchem-2103	44	8	is	be	AUX
eurjchem-2103	44	9	a	a	DET
eurjchem-2103	44	10	very	very	ADV
eurjchem-2103	44	11	effective	effective	ADJ
eurjchem-2103	44	12	tool	tool	NOUN
eurjchem-2103	44	13	which	which	PRON
eurjchem-2103	44	14	explores	explore	VERB
eurjchem-2103	44	15	at	at	ADP
eurjchem-2103	44	16	both	both	CCONJ
eurjchem-2103	44	17	molecular	molecular	ADJ
eurjchem-2103	44	18	and	and	CCONJ
eurjchem-2103	44	19	atomic	atomic	ADJ
eurjchem-2103	44	20	levels	level	NOUN
eurjchem-2103	44	21	the	the	DET
eurjchem-2103	44	22	behavior	behavior	NOUN
eurjchem-2103	44	23	on	on	ADP
eurjchem-2103	44	24	the	the	DET
eurjchem-2103	44	25	ability	ability	NOUN
eurjchem-2103	44	26	to	to	PART
eurjchem-2103	44	27	estimate	estimate	VERB
eurjchem-2103	44	28	the	the	DET
eurjchem-2103	44	29	participation	participation	NOUN
eurjchem-2103	44	30	of	of	ADP
eurjchem-2103	44	31	specific	specific	ADJ
eurjchem-2103	44	32	chemical	chemical	NOUN
eurjchem-2103	44	33	groups	group	NOUN
eurjchem-2103	44	34	and	and	CCONJ
eurjchem-2103	44	35	their	their	PRON
eurjchem-2103	44	36	interactions	interaction	NOUN
eurjchem-2103	44	37	in	in	ADP
eurjchem-2103	44	38	complex	complex	ADJ
eurjchem-2103	44	39	stabilization	stabilization	NOUN
eurjchem-2103	44	40	.	.	PUNCT
eurjchem-2103	45	1	the	the	DET
eurjchem-2103	45	2	lack	lack	NOUN
eurjchem-2103	45	3	of	of	ADP
eurjchem-2103	45	4	this	this	DET
eurjchem-2103	45	5	kind	kind	NOUN
eurjchem-2103	45	6	of	of	ADP
eurjchem-2103	45	7	data	datum	NOUN
eurjchem-2103	45	8	for	for	ADP
eurjchem-2103	45	9	the	the	DET
eurjchem-2103	45	10	three	three	NUM
eurjchem-2103	45	11	cited	cite	VERB
eurjchem-2103	45	12	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	45	13	drove	drive	VERB
eurjchem-2103	45	14	the	the	DET
eurjchem-2103	45	15	work	work	NOUN
eurjchem-2103	45	16	to	to	PART
eurjchem-2103	45	17	fill	fill	VERB
eurjchem-2103	45	18	this	this	DET
eurjchem-2103	45	19	blank	blank	NOUN
eurjchem-2103	45	20	.	.	PUNCT
eurjchem-2103	46	1	thus	thus	ADV
eurjchem-2103	46	2	,	,	PUNCT
eurjchem-2103	46	3	to	to	PART
eurjchem-2103	46	4	complement	complement	VERB
eurjchem-2103	46	5	the	the	DET
eurjchem-2103	46	6	studies	study	NOUN
eurjchem-2103	46	7	of	of	ADP
eurjchem-2103	46	8	biodistribution	biodistribution	NOUN
eurjchem-2103	46	9	of	of	ADP
eurjchem-2103	46	10	cip	cip	NOUN
eurjchem-2103	46	11	,	,	PUNCT
eurjchem-2103	46	12	enr	enr	PROPN
eurjchem-2103	46	13	and	and	CCONJ
eurjchem-2103	46	14	pef	pef	NOUN
eurjchem-2103	46	15	in	in	ADP
eurjchem-2103	46	16	the	the	DET
eurjchem-2103	46	17	bovine	bovine	NOUN
eurjchem-2103	46	18	blood	blood	NOUN
eurjchem-2103	46	19	plasma	plasma	NOUN
eurjchem-2103	46	20	,	,	PUNCT
eurjchem-2103	46	21	molecular	molecular	ADJ
eurjchem-2103	46	22	docking	docking	NOUN
eurjchem-2103	46	23	calculations	calculation	NOUN
eurjchem-2103	46	24	under	under	ADP
eurjchem-2103	46	25	physiological	physiological	ADJ
eurjchem-2103	46	26	conditions	condition	NOUN
eurjchem-2103	46	27	(	(	PUNCT
eurjchem-2103	46	28	ph	ph	NOUN
eurjchem-2103	46	29	=	=	NOUN
eurjchem-2103	46	30	7.4	7.4	NUM
eurjchem-2103	46	31	)	)	PUNCT
eurjchem-2103	46	32	were	be	AUX
eurjchem-2103	46	33	carried	carry	VERB
eurjchem-2103	46	34	.	.	PUNCT
eurjchem-2103	47	1	for	for	ADP
eurjchem-2103	47	2	the	the	DET
eurjchem-2103	47	3	present	present	ADJ
eurjchem-2103	47	4	study	study	NOUN
eurjchem-2103	47	5	,	,	PUNCT
eurjchem-2103	47	6	we	we	PRON
eurjchem-2103	47	7	were	be	AUX
eurjchem-2103	47	8	chosen	choose	VERB
eurjchem-2103	47	9	cip	cip	PROPN
eurjchem-2103	47	10	/	/	SYM
eurjchem-2103	47	11	enr	enr	PROPN
eurjchem-2103	47	12	/	/	SYM
eurjchem-2103	47	13	pef	pef	NOUN
eurjchem-2103	47	14	as	as	ADP
eurjchem-2103	47	15	three	three	NUM
eurjchem-2103	47	16	representative	representative	ADJ
eurjchem-2103	47	17	commercial	commercial	ADJ
eurjchem-2103	47	18	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	47	19	,	,	PUNCT
eurjchem-2103	47	20	due	due	ADP
eurjchem-2103	47	21	to	to	ADP
eurjchem-2103	47	22	their	their	PRON
eurjchem-2103	47	23	high	high	ADJ
eurjchem-2103	47	24	importance	importance	NOUN
eurjchem-2103	47	25	and	and	CCONJ
eurjchem-2103	47	26	wide	wide	ADJ
eurjchem-2103	47	27	application	application	NOUN
eurjchem-2103	47	28	in	in	ADP
eurjchem-2103	47	29	veterinary	veterinary	ADJ
eurjchem-2103	47	30	medicine	medicine	NOUN
eurjchem-2103	47	31	.	.	PUNCT
eurjchem-2103	48	1	2	2	X
eurjchem-2103	48	2	.	.	X
eurjchem-2103	48	3	experimental	experimental	ADJ
eurjchem-2103	48	4	2.1	2.1	NUM
eurjchem-2103	48	5	.	.	PUNCT
eurjchem-2103	48	6	molecular	molecular	ADJ
eurjchem-2103	48	7	descriptor	descriptor	NOUN
eurjchem-2103	48	8	calculation	calculation	NOUN
eurjchem-2103	48	9	the	the	DET
eurjchem-2103	48	10	crystallographic	crystallographic	ADJ
eurjchem-2103	48	11	structure	structure	NOUN
eurjchem-2103	48	12	of	of	ADP
eurjchem-2103	48	13	bsa	bsa	PROPN
eurjchem-2103	48	14	was	be	AUX
eurjchem-2103	48	15	obtained	obtain	VERB
eurjchem-2103	48	16	from	from	ADP
eurjchem-2103	48	17	the	the	DET
eurjchem-2103	48	18	protein	protein	NOUN
eurjchem-2103	48	19	data	data	PROPN
eurjchem-2103	48	20	bank	bank	PROPN
eurjchem-2103	48	21	(	(	PUNCT
eurjchem-2103	48	22	pdb	pdb	PROPN
eurjchem-2103	48	23	)	)	PUNCT
eurjchem-2103	48	24	with	with	ADP
eurjchem-2103	48	25	access	access	NOUN
eurjchem-2103	48	26	code	code	NOUN
eurjchem-2103	48	27	4f5s	4f5s	NUM
eurjchem-2103	49	1	[	[	X
eurjchem-2103	49	2	32	32	NUM
eurjchem-2103	49	3	]	]	PUNCT
eurjchem-2103	49	4	.	.	PUNCT
eurjchem-2103	50	1	this	this	DET
eurjchem-2103	50	2	structure	structure	NOUN
eurjchem-2103	50	3	has	have	VERB
eurjchem-2103	50	4	a	a	DET
eurjchem-2103	50	5	resolution	resolution	NOUN
eurjchem-2103	50	6	of	of	ADP
eurjchem-2103	50	7	2.47	2.47	NUM
eurjchem-2103	50	8	å	å	NOUN
eurjchem-2103	50	9	.	.	PUNCT
eurjchem-2103	51	1	the	the	DET
eurjchem-2103	51	2	cip	cip	NOUN
eurjchem-2103	51	3	,	,	PUNCT
eurjchem-2103	51	4	enr	enr	PROPN
eurjchem-2103	51	5	,	,	PUNCT
eurjchem-2103	51	6	and	and	CCONJ
eurjchem-2103	51	7	pef	pef	NOUN
eurjchem-2103	51	8	structures	structure	NOUN
eurjchem-2103	51	9	were	be	AUX
eurjchem-2103	51	10	built	build	VERB
eurjchem-2103	51	11	and	and	CCONJ
eurjchem-2103	51	12	energy	energy	NOUN
eurjchem-2103	51	13	minimized	minimized	NOUN
eurjchem-2103	51	14	at	at	ADP
eurjchem-2103	51	15	physiological	physiological	ADJ
eurjchem-2103	51	16	ph	ph	NOUN
eurjchem-2103	51	17	(	(	PUNCT
eurjchem-2103	51	18	ph	ph	NOUN
eurjchem-2103	51	19	=	=	NOUN
eurjchem-2103	51	20	7.40	7.40	NUM
eurjchem-2103	51	21	)	)	PUNCT
eurjchem-2103	51	22	with	with	ADP
eurjchem-2103	51	23	the	the	DET
eurjchem-2103	51	24	density	density	NOUN
eurjchem-2103	51	25	functional	functional	ADJ
eurjchem-2103	51	26	theory	theory	NOUN
eurjchem-2103	51	27	(	(	PUNCT
eurjchem-2103	51	28	dft	dft	NOUN
eurjchem-2103	51	29	)	)	PUNCT
eurjchem-2103	51	30	method	method	NOUN
eurjchem-2103	51	31	b3lyp/6	b3lyp/6	PROPN
eurjchem-2103	51	32	-	-	PUNCT
eurjchem-2103	51	33	31	31	NUM
eurjchem-2103	51	34	g	g	NOUN
eurjchem-2103	51	35	*	*	PUNCT
eurjchem-2103	51	36	available	available	ADJ
eurjchem-2103	51	37	at	at	ADP
eurjchem-2103	51	38	the	the	DET
eurjchem-2103	51	39	spartan’14	spartan’14	PROPN
eurjchem-2103	51	40	software	software	NOUN
eurjchem-2103	51	41	(	(	PUNCT
eurjchem-2103	51	42	wavefunction	wavefunction	NOUN
eurjchem-2103	51	43	,	,	PUNCT
eurjchem-2103	51	44	inc	inc	PROPN
eurjchem-2103	51	45	.	.	PROPN
eurjchem-2103	51	46	)	)	PUNCT
eurjchem-2103	51	47	.	.	PUNCT
eurjchem-2103	52	1	the	the	DET
eurjchem-2103	52	2	molecular	molecular	ADJ
eurjchem-2103	52	3	docking	docking	NOUN
eurjchem-2103	52	4	was	be	AUX
eurjchem-2103	52	5	performed	perform	VERB
eurjchem-2103	52	6	with	with	ADP
eurjchem-2103	52	7	the	the	DET
eurjchem-2103	52	8	gold	gold	ADJ
eurjchem-2103	52	9	5.6	5.6	NUM
eurjchem-2103	52	10	software	software	NOUN
eurjchem-2103	52	11	(	(	PUNCT
eurjchem-2103	52	12	cambridge	cambridge	PROPN
eurjchem-2103	52	13	crystallographic	crystallographic	PROPN
eurjchem-2103	52	14	data	data	PROPN
eurjchem-2103	52	15	centre	centre	PROPN
eurjchem-2103	52	16	ccdc	ccdc	PROPN
eurjchem-2103	52	17	)	)	PUNCT
eurjchem-2103	52	18	.	.	PUNCT
eurjchem-2103	53	1	the	the	DET
eurjchem-2103	53	2	crystallographic	crystallographic	ADJ
eurjchem-2103	53	3	hydration	hydration	NOUN
eurjchem-2103	53	4	molecules	molecule	NOUN
eurjchem-2103	53	5	were	be	AUX
eurjchem-2103	53	6	deleted	delete	VERB
eurjchem-2103	53	7	and	and	CCONJ
eurjchem-2103	53	8	hydrogen	hydrogen	NOUN
eurjchem-2103	53	9	atoms	atom	NOUN
eurjchem-2103	53	10	were	be	AUX
eurjchem-2103	53	11	added	add	VERB
eurjchem-2103	53	12	to	to	ADP
eurjchem-2103	53	13	the	the	DET
eurjchem-2103	53	14	protein	protein	NOUN
eurjchem-2103	53	15	according	accord	VERB
eurjchem-2103	53	16	to	to	ADP
eurjchem-2103	53	17	the	the	DET
eurjchem-2103	53	18	data	datum	NOUN
eurjchem-2103	53	19	inferred	infer	VERB
eurjchem-2103	53	20	by	by	ADP
eurjchem-2103	53	21	gold	gold	NOUN
eurjchem-2103	53	22	5.6	5.6	NUM
eurjchem-2103	53	23	software	software	NOUN
eurjchem-2103	53	24	on	on	ADP
eurjchem-2103	53	25	the	the	DET
eurjchem-2103	53	26	ionization	ionization	NOUN
eurjchem-2103	53	27	and	and	CCONJ
eurjchem-2103	53	28	tautomeric	tautomeric	ADJ
eurjchem-2103	53	29	states	state	NOUN
eurjchem-2103	53	30	[	[	X
eurjchem-2103	53	31	33	33	NUM
eurjchem-2103	53	32	]	]	PUNCT
eurjchem-2103	53	33	.	.	PUNCT
eurjchem-2103	54	1	to	to	PART
eurjchem-2103	54	2	evaluate	evaluate	VERB
eurjchem-2103	54	3	the	the	DET
eurjchem-2103	54	4	best	good	ADJ
eurjchem-2103	54	5	scoring	scoring	NOUN
eurjchem-2103	54	6	function	function	NOUN
eurjchem-2103	54	7	that	that	PRON
eurjchem-2103	54	8	will	will	AUX
eurjchem-2103	54	9	be	be	AUX
eurjchem-2103	54	10	used	use	VERB
eurjchem-2103	54	11	in	in	ADP
eurjchem-2103	54	12	the	the	DET
eurjchem-2103	54	13	molecular	molecular	ADJ
eurjchem-2103	54	14	docking	docking	NOUN
eurjchem-2103	54	15	run	run	NOUN
eurjchem-2103	54	16	(	(	PUNCT
eurjchem-2103	54	17	chemplp	chemplp	ADJ
eurjchem-2103	54	18	,	,	PUNCT
eurjchem-2103	54	19	goldscore	goldscore	ADJ
eurjchem-2103	54	20	,	,	PUNCT
eurjchem-2103	54	21	chemscore	chemscore	ADV
eurjchem-2103	54	22	,	,	PUNCT
eurjchem-2103	54	23	or	or	CCONJ
eurjchem-2103	54	24	asp	asp	NOUN
eurjchem-2103	54	25	)	)	PUNCT
eurjchem-2103	54	26	,	,	PUNCT
eurjchem-2103	54	27	redocking	redocking	NOUN
eurjchem-2103	54	28	study	study	NOUN
eurjchem-2103	54	29	was	be	AUX
eurjchem-2103	54	30	carried	carry	VERB
eurjchem-2103	54	31	out	out	ADP
eurjchem-2103	54	32	with	with	ADP
eurjchem-2103	54	33	the	the	DET
eurjchem-2103	54	34	crystallographic	crystallographic	ADJ
eurjchem-2103	54	35	ligand	ligand	NOUN
eurjchem-2103	54	36	naproxen	naproxen	PROPN
eurjchem-2103	54	37	inside	inside	ADP
eurjchem-2103	54	38	bsa	bsa	PROPN
eurjchem-2103	54	39	binding	bind	VERB
eurjchem-2103	54	40	pocket	pocket	NOUN
eurjchem-2103	54	41	(	(	PUNCT
eurjchem-2103	54	42	trp-212	trp-212	NOUN
eurjchem-2103	54	43	-	-	PUNCT
eurjchem-2103	54	44	containing	contain	VERB
eurjchem-2103	54	45	binding	bind	VERB
eurjchem-2103	54	46	site	site	NOUN
eurjchem-2103	54	47	–	–	PUNCT
eurjchem-2103	54	48	pdb	pdb	PROPN
eurjchem-2103	54	49	code	code	NOUN
eurjchem-2103	54	50	:	:	PUNCT
eurjchem-2103	54	51	4or0	4or0	NUM
eurjchem-2103	54	52	)	)	PUNCT
eurjchem-2103	55	1	[	[	X
eurjchem-2103	55	2	34	34	NUM
eurjchem-2103	55	3	]	]	PUNCT
eurjchem-2103	55	4	.	.	PUNCT
eurjchem-2103	56	1	the	the	DET
eurjchem-2103	56	2	root	root	NOUN
eurjchem-2103	56	3	mean	mean	VERB
eurjchem-2103	56	4	square	square	ADJ
eurjchem-2103	56	5	deviation	deviation	NOUN
eurjchem-2103	56	6	(	(	PUNCT
eurjchem-2103	56	7	rmsd	rmsd	NOUN
eurjchem-2103	56	8	)	)	PUNCT
eurjchem-2103	56	9	obtained	obtain	VERB
eurjchem-2103	56	10	for	for	ADP
eurjchem-2103	56	11	chemplp	chemplp	ADJ
eurjchem-2103	56	12	,	,	PUNCT
eurjchem-2103	56	13	goldscore	goldscore	ADJ
eurjchem-2103	56	14	,	,	PUNCT
eurjchem-2103	56	15	chemscore	chemscore	ADV
eurjchem-2103	56	16	,	,	PUNCT
eurjchem-2103	56	17	and	and	CCONJ
eurjchem-2103	56	18	asp	asp	PROPN
eurjchem-2103	56	19	was	be	AUX
eurjchem-2103	56	20	0.512	0.512	NUM
eurjchem-2103	56	21	,	,	PUNCT
eurjchem-2103	56	22	1.103	1.103	NUM
eurjchem-2103	56	23	,	,	PUNCT
eurjchem-2103	56	24	0.811	0.811	NUM
eurjchem-2103	56	25	,	,	PUNCT
eurjchem-2103	56	26	and	and	CCONJ
eurjchem-2103	56	27	1.415	1.415	NUM
eurjchem-2103	56	28	,	,	PUNCT
eurjchem-2103	56	29	respectively	respectively	ADV
eurjchem-2103	56	30	.	.	PUNCT
eurjchem-2103	57	1	since	since	SCONJ
eurjchem-2103	57	2	chemplp	chemplp	NOUN
eurjchem-2103	57	3	function	function	NOUN
eurjchem-2103	57	4	provided	provide	VERB
eurjchem-2103	57	5	the	the	DET
eurjchem-2103	57	6	lowest	low	ADJ
eurjchem-2103	57	7	rmsd	rmsd	NOUN
eurjchem-2103	57	8	value	value	NOUN
eurjchem-2103	57	9	,	,	PUNCT
eurjchem-2103	57	10	there	there	PRON
eurjchem-2103	57	11	is	be	VERB
eurjchem-2103	57	12	a	a	DET
eurjchem-2103	57	13	clear	clear	ADJ
eurjchem-2103	57	14	indication	indication	NOUN
eurjchem-2103	57	15	that	that	SCONJ
eurjchem-2103	57	16	this	this	DET
eurjchem-2103	57	17	scoring	scoring	NOUN
eurjchem-2103	57	18	function	function	NOUN
eurjchem-2103	57	19	is	be	AUX
eurjchem-2103	57	20	the	the	DET
eurjchem-2103	57	21	best	good	ADJ
eurjchem-2103	57	22	choice	choice	NOUN
eurjchem-2103	57	23	to	to	PART
eurjchem-2103	57	24	be	be	AUX
eurjchem-2103	57	25	applied	apply	VERB
eurjchem-2103	57	26	in	in	ADP
eurjchem-2103	57	27	the	the	DET
eurjchem-2103	57	28	molecular	molecular	ADJ
eurjchem-2103	57	29	docking	docking	NOUN
eurjchem-2103	57	30	studies	study	NOUN
eurjchem-2103	57	31	for	for	ADP
eurjchem-2103	57	32	the	the	DET
eurjchem-2103	57	33	three	three	NUM
eurjchem-2103	57	34	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	57	35	.	.	PUNCT
eurjchem-2103	58	1	the	the	DET
eurjchem-2103	58	2	data	datum	NOUN
eurjchem-2103	58	3	available	available	ADJ
eurjchem-2103	58	4	from	from	ADP
eurjchem-2103	58	5	literature	literature	NOUN
eurjchem-2103	58	6	by	by	ADP
eurjchem-2103	58	7	spectroscopic	spectroscopic	ADJ
eurjchem-2103	58	8	assays	assay	NOUN
eurjchem-2103	58	9	(	(	PUNCT
eurjchem-2103	58	10	fluorescence	fluorescence	NOUN
eurjchem-2103	58	11	quenching	quenching	NOUN
eurjchem-2103	58	12	studies	study	NOUN
eurjchem-2103	58	13	)	)	PUNCT
eurjchem-2103	58	14	described	describe	VERB
eurjchem-2103	58	15	that	that	SCONJ
eurjchem-2103	58	16	cip	cip	NOUN
eurjchem-2103	58	17	,	,	PUNCT
eurjchem-2103	58	18	enr	enr	PROPN
eurjchem-2103	58	19	and	and	CCONJ
eurjchem-2103	58	20	pef	pef	PROPN
eurjchem-2103	58	21	interact	interact	PROPN
eurjchem-2103	58	22	with	with	ADP
eurjchem-2103	58	23	bsa	bsa	PROPN
eurjchem-2103	58	24	possibly	possibly	ADV
eurjchem-2103	58	25	bound	bind	VERB
eurjchem-2103	58	26	next	next	ADV
eurjchem-2103	58	27	to	to	ADP
eurjchem-2103	58	28	one	one	NUM
eurjchem-2103	58	29	of	of	ADP
eurjchem-2103	58	30	the	the	DET
eurjchem-2103	58	31	internal	internal	ADJ
eurjchem-2103	58	32	tryptophans	tryptophans	PROPN
eurjchem-2103	58	33	(	(	PUNCT
eurjchem-2103	58	34	trp-134	trp-134	NOUN
eurjchem-2103	58	35	or	or	CCONJ
eurjchem-2103	58	36	trp-212	trp-212	ADJ
eurjchem-2103	58	37	)	)	PUNCT
eurjchem-2103	59	1	[	[	X
eurjchem-2103	59	2	6,22	6,22	NOUN
eurjchem-2103	59	3	-	-	PUNCT
eurjchem-2103	59	4	31	31	NUM
eurjchem-2103	59	5	]	]	PUNCT
eurjchem-2103	59	6	.	.	PUNCT
eurjchem-2103	60	1	from	from	ADP
eurjchem-2103	60	2	this	this	DET
eurjchem-2103	60	3	data	data	NOUN
eurjchem-2103	60	4	,	,	PUNCT
eurjchem-2103	60	5	to	to	PART
eurjchem-2103	60	6	identify	identify	VERB
eurjchem-2103	60	7	the	the	DET
eurjchem-2103	60	8	main	main	ADJ
eurjchem-2103	60	9	binding	bind	VERB
eurjchem-2103	60	10	site	site	NOUN
eurjchem-2103	60	11	of	of	ADP
eurjchem-2103	60	12	bsa	bsa	PROPN
eurjchem-2103	60	13	,	,	PUNCT
eurjchem-2103	60	14	it	it	PRON
eurjchem-2103	60	15	was	be	AUX
eurjchem-2103	60	16	defined	define	VERB
eurjchem-2103	60	17	10	10	NUM
eurjchem-2103	60	18	å	å	PROPN
eurjchem-2103	60	19	spherical	spherical	ADJ
eurjchem-2103	60	20	radius	radius	NOUN
eurjchem-2103	60	21	around	around	ADP
eurjchem-2103	60	22	each	each	DET
eurjchem-2103	60	23	tryptophan	tryptophan	NOUN
eurjchem-2103	60	24	residue	residue	NOUN
eurjchem-2103	60	25	to	to	ADP
eurjchem-2103	60	26	molecular	molecular	ADJ
eurjchem-2103	60	27	docking	docking	NOUN
eurjchem-2103	60	28	calculations	calculation	NOUN
eurjchem-2103	60	29	.	.	PUNCT
eurjchem-2103	61	1	the	the	DET
eurjchem-2103	61	2	docking	dock	VERB
eurjchem-2103	61	3	score	score	NOUN
eurjchem-2103	61	4	of	of	ADP
eurjchem-2103	61	5	each	each	DET
eurjchem-2103	61	6	pose	pose	NOUN
eurjchem-2103	61	7	was	be	AUX
eurjchem-2103	61	8	obtained	obtain	VERB
eurjchem-2103	61	9	through	through	ADP
eurjchem-2103	61	10	the	the	DET
eurjchem-2103	61	11	sum	sum	NOUN
eurjchem-2103	61	12	of	of	ADP
eurjchem-2103	61	13	a	a	DET
eurjchem-2103	61	14	series	series	NOUN
eurjchem-2103	61	15	of	of	ADP
eurjchem-2103	61	16	energy	energy	NOUN
eurjchem-2103	61	17	terms	term	NOUN
eurjchem-2103	61	18	involved	involve	VERB
eurjchem-2103	61	19	in	in	ADP
eurjchem-2103	61	20	the	the	DET
eurjchem-2103	61	21	protein	protein	NOUN
eurjchem-2103	61	22	-	-	PUNCT
eurjchem-2103	61	23	ligand	ligand	NOUN
eurjchem-2103	61	24	interaction	interaction	NOUN
eurjchem-2103	61	25	process	process	NOUN
eurjchem-2103	61	26	,	,	PUNCT
eurjchem-2103	61	27	so	so	SCONJ
eurjchem-2103	61	28	a	a	DET
eurjchem-2103	61	29	more	more	ADV
eurjchem-2103	61	30	positive	positive	ADJ
eurjchem-2103	61	31	score	score	NOUN
eurjchem-2103	61	32	indicates	indicate	VERB
eurjchem-2103	61	33	a	a	DET
eurjchem-2103	61	34	better	well	ADJ
eurjchem-2103	61	35	interaction	interaction	NOUN
eurjchem-2103	61	36	[	[	X
eurjchem-2103	61	37	35	35	NUM
eurjchem-2103	61	38	]	]	PUNCT
eurjchem-2103	61	39	.	.	PUNCT
eurjchem-2103	62	1	the	the	DET
eurjchem-2103	62	2	number	number	NOUN
eurjchem-2103	62	3	of	of	ADP
eurjchem-2103	62	4	genetic	genetic	ADJ
eurjchem-2103	62	5	operations	operation	NOUN
eurjchem-2103	62	6	(	(	PUNCT
eurjchem-2103	62	7	crossover	crossover	NOUN
eurjchem-2103	62	8	,	,	PUNCT
eurjchem-2103	62	9	migration	migration	NOUN
eurjchem-2103	62	10	,	,	PUNCT
eurjchem-2103	62	11	mutation	mutation	NOUN
eurjchem-2103	62	12	)	)	PUNCT
eurjchem-2103	62	13	in	in	ADP
eurjchem-2103	62	14	each	each	DET
eurjchem-2103	62	15	docking	docking	NOUN
eurjchem-2103	62	16	run	run	NOUN
eurjchem-2103	62	17	used	use	VERB
eurjchem-2103	62	18	in	in	ADP
eurjchem-2103	62	19	the	the	DET
eurjchem-2103	62	20	searching	search	VERB
eurjchem-2103	62	21	procedure	procedure	NOUN
eurjchem-2103	62	22	was	be	AUX
eurjchem-2103	62	23	set	set	VERB
eurjchem-2103	62	24	to	to	ADP
eurjchem-2103	62	25	100,000	100,000	NUM
eurjchem-2103	62	26	.	.	PUNCT
eurjchem-2103	63	1	it	it	PRON
eurjchem-2103	63	2	was	be	AUX
eurjchem-2103	63	3	used	use	VERB
eurjchem-2103	63	4	student	student	NOUN
eurjchem-2103	63	5	’s	’s	PART
eurjchem-2103	63	6	t	t	PROPN
eurjchem-2103	63	7	-	-	PUNCT
eurjchem-2103	63	8	test	test	NOUN
eurjchem-2103	63	9	to	to	PART
eurjchem-2103	63	10	determine	determine	VERB
eurjchem-2103	63	11	statistical	statistical	ADJ
eurjchem-2103	63	12	significance	significance	NOUN
eurjchem-2103	63	13	between	between	ADP
eurjchem-2103	63	14	the	the	DET
eurjchem-2103	63	15	data	datum	NOUN
eurjchem-2103	63	16	obtained	obtain	VERB
eurjchem-2103	63	17	for	for	ADP
eurjchem-2103	63	18	the	the	DET
eurjchem-2103	63	19	two	two	NUM
eurjchem-2103	63	20	binding	bind	VERB
eurjchem-2103	63	21	sites	site	NOUN
eurjchem-2103	63	22	.	.	PUNCT
eurjchem-2103	64	1	the	the	DET
eurjchem-2103	64	2	figures	figure	NOUN
eurjchem-2103	64	3	of	of	ADP
eurjchem-2103	64	4	the	the	DET
eurjchem-2103	64	5	docking	docking	NOUN
eurjchem-2103	64	6	poses	pose	VERB
eurjchem-2103	64	7	with	with	ADP
eurjchem-2103	64	8	the	the	DET
eurjchem-2103	64	9	highest	high	ADJ
eurjchem-2103	64	10	docking	docking	NOUN
eurjchem-2103	64	11	score	score	NOUN
eurjchem-2103	64	12	value	value	NOUN
eurjchem-2103	64	13	were	be	AUX
eurjchem-2103	64	14	generated	generate	VERB
eurjchem-2103	64	15	with	with	ADP
eurjchem-2103	64	16	the	the	DET
eurjchem-2103	64	17	pymol	pymol	PROPN
eurjchem-2103	64	18	delano	delano	PROPN
eurjchem-2103	64	19	scientific	scientific	PROPN
eurjchem-2103	64	20	llc	llc	PROPN
eurjchem-2103	64	21	software	software	NOUN
eurjchem-2103	64	22	[	[	X
eurjchem-2103	64	23	36	36	NUM
eurjchem-2103	64	24	]	]	PUNCT
eurjchem-2103	64	25	.	.	PUNCT
eurjchem-2103	65	1	additionally	additionally	ADV
eurjchem-2103	65	2	,	,	PUNCT
eurjchem-2103	65	3	in	in	ADP
eurjchem-2103	65	4	order	order	NOUN
eurjchem-2103	65	5	to	to	PART
eurjchem-2103	65	6	verify	verify	VERB
eurjchem-2103	65	7	the	the	DET
eurjchem-2103	65	8	frequency	frequency	NOUN
eurjchem-2103	65	9	calculation	calculation	NOUN
eurjchem-2103	65	10	,	,	PUNCT
eurjchem-2103	65	11	the	the	DET
eurjchem-2103	65	12	molecular	molecular	ADJ
eurjchem-2103	65	13	docking	docking	NOUN
eurjchem-2103	65	14	calculations	calculation	NOUN
eurjchem-2103	65	15	were	be	AUX
eurjchem-2103	65	16	carried	carry	VERB
eurjchem-2103	65	17	out	out	ADP
eurjchem-2103	65	18	three	three	NUM
eurjchem-2103	65	19	times	time	NOUN
eurjchem-2103	65	20	selecting	select	VERB
eurjchem-2103	65	21	the	the	DET
eurjchem-2103	65	22	same	same	ADJ
eurjchem-2103	65	23	binding	bind	VERB
eurjchem-2103	65	24	region	region	NOUN
eurjchem-2103	65	25	and	and	CCONJ
eurjchem-2103	65	26	using	use	VERB
eurjchem-2103	65	27	the	the	DET
eurjchem-2103	65	28	same	same	ADJ
eurjchem-2103	65	29	spherical	spherical	ADJ
eurjchem-2103	65	30	radius	radius	NOUN
eurjchem-2103	65	31	.	.	PUNCT
eurjchem-2103	66	1	in	in	ADP
eurjchem-2103	66	2	all	all	DET
eurjchem-2103	66	3	cases	case	NOUN
eurjchem-2103	66	4	,	,	PUNCT
eurjchem-2103	66	5	the	the	DET
eurjchem-2103	66	6	best	good	ADJ
eurjchem-2103	66	7	docking	docking	NOUN
eurjchem-2103	66	8	pose	pose	NOUN
eurjchem-2103	66	9	was	be	AUX
eurjchem-2103	66	10	obtained	obtain	VERB
eurjchem-2103	66	11	to	to	ADP
eurjchem-2103	66	12	the	the	DET
eurjchem-2103	66	13	same	same	ADJ
eurjchem-2103	66	14	site	site	NOUN
eurjchem-2103	66	15	of	of	ADP
eurjchem-2103	66	16	the	the	DET
eurjchem-2103	66	17	albumin	albumin	ADJ
eurjchem-2103	66	18	structure	structure	NOUN
eurjchem-2103	66	19	,	,	PUNCT
eurjchem-2103	66	20	as	as	ADV
eurjchem-2103	66	21	well	well	ADV
eurjchem-2103	66	22	as	as	ADP
eurjchem-2103	66	23	the	the	DET
eurjchem-2103	66	24	ligand	ligand	NOUN
eurjchem-2103	66	25	assumed	assume	VERB
eurjchem-2103	66	26	a	a	DET
eurjchem-2103	66	27	quite	quite	ADV
eurjchem-2103	66	28	similar	similar	ADJ
eurjchem-2103	66	29	docking	docking	NOUN
eurjchem-2103	66	30	pose	pose	VERB
eurjchem-2103	66	31	.	.	PUNCT
eurjchem-2103	67	1	3	3	X
eurjchem-2103	67	2	.	.	NOUN
eurjchem-2103	67	3	results	result	NOUN
eurjchem-2103	67	4	and	and	CCONJ
eurjchem-2103	67	5	discussion	discussion	NOUN
eurjchem-2103	67	6	the	the	DET
eurjchem-2103	67	7	bsa	bsa	PROPN
eurjchem-2103	67	8	structure	structure	NOUN
eurjchem-2103	67	9	is	be	AUX
eurjchem-2103	67	10	didactically	didactically	ADV
eurjchem-2103	67	11	divided	divide	VERB
eurjchem-2103	67	12	in	in	ADP
eurjchem-2103	67	13	three	three	NUM
eurjchem-2103	67	14	homologous	homologous	ADJ
eurjchem-2103	67	15	helical	helical	ADJ
eurjchem-2103	67	16	domains	domain	NOUN
eurjchem-2103	67	17	:	:	PUNCT
eurjchem-2103	67	18	i	i	PRON
eurjchem-2103	67	19	(	(	PUNCT
eurjchem-2103	67	20	1	1	NUM
eurjchem-2103	67	21	-	-	NUM
eurjchem-2103	67	22	179	179	NUM
eurjchem-2103	67	23	)	)	PUNCT
eurjchem-2103	67	24	,	,	PUNCT
eurjchem-2103	67	25	ii	ii	PROPN
eurjchem-2103	67	26	(	(	PUNCT
eurjchem-2103	67	27	180	180	NUM
eurjchem-2103	67	28	-	-	NUM
eurjchem-2103	67	29	384	384	NUM
eurjchem-2103	67	30	)	)	PUNCT
eurjchem-2103	67	31	,	,	PUNCT
eurjchem-2103	67	32	and	and	CCONJ
eurjchem-2103	67	33	iii	iii	X
eurjchem-2103	67	34	(	(	PUNCT
eurjchem-2103	67	35	385583	385583	NUM
eurjchem-2103	67	36	)	)	PUNCT
eurjchem-2103	67	37	,	,	PUNCT
eurjchem-2103	67	38	which	which	PRON
eurjchem-2103	67	39	show	show	VERB
eurjchem-2103	67	40	different	different	ADJ
eurjchem-2103	67	41	binding	bind	VERB
eurjchem-2103	67	42	abilities	ability	NOUN
eurjchem-2103	67	43	toward	toward	ADP
eurjchem-2103	67	44	small	small	ADJ
eurjchem-2103	67	45	molecules	molecule	NOUN
eurjchem-2103	67	46	[	[	X
eurjchem-2103	67	47	19,21,32,37	19,21,32,37	NUM
eurjchem-2103	67	48	]	]	PUNCT
eurjchem-2103	67	49	.	.	PUNCT
eurjchem-2103	68	1	is	be	AUX
eurjchem-2103	68	2	shown	show	VERB
eurjchem-2103	68	3	in	in	ADP
eurjchem-2103	68	4	figure	figure	NOUN
eurjchem-2103	68	5	2	2	NUM
eurjchem-2103	68	6	,	,	PUNCT
eurjchem-2103	68	7	the	the	DET
eurjchem-2103	68	8	bsa	bsa	PROPN
eurjchem-2103	68	9	structure	structure	NOUN
eurjchem-2103	68	10	presenting	present	VERB
eurjchem-2103	68	11	two	two	NUM
eurjchem-2103	68	12	internal	internal	ADJ
eurjchem-2103	68	13	tryptophan	tryptophan	NOUN
eurjchem-2103	68	14	residues	residue	NOUN
eurjchem-2103	68	15	:	:	PUNCT
eurjchem-2103	68	16	trp-134	trp-134	NOUN
eurjchem-2103	68	17	located	locate	VERB
eurjchem-2103	68	18	in	in	ADP
eurjchem-2103	68	19	domain	domain	NOUN
eurjchem-2103	69	1	i	i	PRON
eurjchem-2103	69	2	(	(	PUNCT
eurjchem-2103	69	3	generally	generally	ADV
eurjchem-2103	69	4	known	know	VERB
eurjchem-2103	69	5	as	as	ADP
eurjchem-2103	69	6	site	site	NOUN
eurjchem-2103	69	7	iii	iii	NOUN
eurjchem-2103	69	8	)	)	PUNCT
eurjchem-2103	69	9	and	and	CCONJ
eurjchem-2103	69	10	trp-212	trp-212	NOUN
eurjchem-2103	69	11	located	locate	VERB
eurjchem-2103	69	12	in	in	ADP
eurjchem-2103	69	13	the	the	DET
eurjchem-2103	69	14	domain	domain	NOUN
eurjchem-2103	69	15	ii	ii	NOUN
eurjchem-2103	69	16	(	(	PUNCT
eurjchem-2103	69	17	generally	generally	ADV
eurjchem-2103	69	18	known	know	VERB
eurjchem-2103	69	19	as	as	ADP
eurjchem-2103	69	20	site	site	NOUN
eurjchem-2103	69	21	i	i	NOUN
eurjchem-2103	69	22	)	)	PUNCT
eurjchem-2103	70	1	[	[	X
eurjchem-2103	70	2	32,35	32,35	NOUN
eurjchem-2103	70	3	]	]	PUNCT
eurjchem-2103	70	4	.	.	PUNCT
eurjchem-2103	71	1	from	from	ADP
eurjchem-2103	71	2	the	the	DET
eurjchem-2103	71	3	literature	literature	NOUN
eurjchem-2103	71	4	it	it	PRON
eurjchem-2103	71	5	is	be	AUX
eurjchem-2103	71	6	known	know	VERB
eurjchem-2103	71	7	that	that	SCONJ
eurjchem-2103	71	8	the	the	DET
eurjchem-2103	71	9	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	71	10	cip	cip	PROPN
eurjchem-2103	71	11	,	,	PUNCT
eurjchem-2103	71	12	enr	enr	PROPN
eurjchem-2103	71	13	and	and	CCONJ
eurjchem-2103	71	14	pef	pef	NOUN
eurjchem-2103	71	15	are	be	AUX
eurjchem-2103	71	16	able	able	ADJ
eurjchem-2103	71	17	to	to	PART
eurjchem-2103	71	18	quench	quench	VERB
eurjchem-2103	71	19	the	the	DET
eurjchem-2103	71	20	bsa	bsa	PROPN
eurjchem-2103	71	21	intrinsic	intrinsic	ADJ
eurjchem-2103	71	22	fluorescence	fluorescence	NOUN
eurjchem-2103	71	23	,	,	PUNCT
eurjchem-2103	71	24	indicating	indicate	VERB
eurjchem-2103	71	25	that	that	SCONJ
eurjchem-2103	71	26	probably	probably	ADV
eurjchem-2103	71	27	these	these	DET
eurjchem-2103	71	28	ligands	ligand	NOUN
eurjchem-2103	71	29	might	might	AUX
eurjchem-2103	71	30	be	be	AUX
eurjchem-2103	71	31	bound	bind	VERB
eurjchem-2103	71	32	next	next	ADP
eurjchem-2103	71	33	one	one	NUM
eurjchem-2103	71	34	of	of	ADP
eurjchem-2103	71	35	the	the	DET
eurjchem-2103	71	36	two	two	NUM
eurjchem-2103	71	37	tryptophan	tryptophan	NOUN
eurjchem-2103	71	38	residues	residue	NOUN
eurjchem-2103	71	39	[	[	X
eurjchem-2103	71	40	22	22	NUM
eurjchem-2103	71	41	-	-	SYM
eurjchem-2103	71	42	31	31	NUM
eurjchem-2103	71	43	]	]	PUNCT
eurjchem-2103	71	44	.	.	PUNCT
eurjchem-2103	72	1	194	194	NUM
eurjchem-2103	72	2	chaves	chave	NOUN
eurjchem-2103	72	3	and	and	CCONJ
eurjchem-2103	72	4	vazquez	vazquez	PROPN
eurjchem-2103	72	5	/	/	SYM
eurjchem-2103	72	6	european	european	PROPN
eurjchem-2103	72	7	journal	journal	PROPN
eurjchem-2103	72	8	of	of	ADP
eurjchem-2103	72	9	chemistry	chemistry	NOUN
eurjchem-2103	72	10	12	12	NUM
eurjchem-2103	72	11	(	(	PUNCT
eurjchem-2103	72	12	2	2	NUM
eurjchem-2103	72	13	)	)	PUNCT
eurjchem-2103	72	14	(	(	PUNCT
eurjchem-2103	72	15	2021	2021	NUM
eurjchem-2103	72	16	)	)	PUNCT
eurjchem-2103	72	17	192	192	NUM
eurjchem-2103	72	18	-	-	SYM
eurjchem-2103	72	19	196	196	NUM
eurjchem-2103	72	20	2021	2021	NUM
eurjchem-2103	72	21	–	–	PUNCT
eurjchem-2103	72	22	european	european	ADJ
eurjchem-2103	72	23	journal	journal	NOUN
eurjchem-2103	72	24	of	of	ADP
eurjchem-2103	72	25	chemistry	chemistry	NOUN
eurjchem-2103	72	26	–	–	PUNCT
eurjchem-2103	72	27	cc	cc	NOUN
eurjchem-2103	72	28	by	by	ADP
eurjchem-2103	72	29	nc	nc	PROPN
eurjchem-2103	72	30	–	–	PUNCT
eurjchem-2103	72	31	doi	doi	NOUN
eurjchem-2103	72	32	:	:	PUNCT
eurjchem-2103	72	33	10.5155	10.5155	NUM
eurjchem-2103	72	34	/	/	SYM
eurjchem-2103	72	35	eurjchem.12.2.192	eurjchem.12.2.192	NOUN
eurjchem-2103	72	36	-	-	PUNCT
eurjchem-2103	72	37	196.2103	196.2103	NUM
eurjchem-2103	72	38	table	table	NOUN
eurjchem-2103	72	39	1	1	NUM
eurjchem-2103	72	40	.	.	PUNCT
eurjchem-2103	72	41	fitness	fitness	NOUN
eurjchem-2103	72	42	scores	score	NOUN
eurjchem-2103	72	43	(	(	PUNCT
eurjchem-2103	72	44	dimensionless	dimensionless	NOUN
eurjchem-2103	72	45	)	)	PUNCT
eurjchem-2103	72	46	for	for	ADP
eurjchem-2103	72	47	the	the	DET
eurjchem-2103	72	48	best	good	ADJ
eurjchem-2103	72	49	docking	docking	NOUN
eurjchem-2103	72	50	poses	pose	NOUN
eurjchem-2103	72	51	in	in	ADP
eurjchem-2103	72	52	the	the	DET
eurjchem-2103	72	53	trp-134and	trp-134and	PROPN
eurjchem-2103	72	54	trp-212	trp-212	NOUN
eurjchem-2103	72	55	-	-	PUNCT
eurjchem-2103	72	56	containing	contain	VERB
eurjchem-2103	72	57	binding	bind	VERB
eurjchem-2103	72	58	sites	site	NOUN
eurjchem-2103	72	59	for	for	ADP
eurjchem-2103	72	60	bsa	bsa	PROPN
eurjchem-2103	72	61	:	:	PUNCT
eurjchem-2103	72	62	cip	cip	PROPN
eurjchem-2103	72	63	,	,	PUNCT
eurjchem-2103	72	64	bsa	bsa	PROPN
eurjchem-2103	72	65	:	:	PUNCT
eurjchem-2103	72	66	enr	enr	PROPN
eurjchem-2103	72	67	,	,	PUNCT
eurjchem-2103	72	68	and	and	CCONJ
eurjchem-2103	72	69	bsa	bsa	PROPN
eurjchem-2103	72	70	:	:	PUNCT
eurjchem-2103	72	71	pef	pef	PROPN
eurjchem-2103	72	72	(	(	PUNCT
eurjchem-2103	72	73	chemplp	chemplp	NOUN
eurjchem-2103	72	74	function	function	NOUN
eurjchem-2103	72	75	)	)	PUNCT
eurjchem-2103	72	76	.	.	PUNCT
eurjchem-2103	73	1	bsa	bsa	PROPN
eurjchem-2103	73	2	:	:	PUNCT
eurjchem-2103	73	3	cip	cip	PROPN
eurjchem-2103	73	4	bsa	bsa	PROPN
eurjchem-2103	73	5	:	:	PUNCT
eurjchem-2103	73	6	enr	enr	PROPN
eurjchem-2103	73	7	bsa	bsa	PROPN
eurjchem-2103	73	8	:	:	PUNCT
eurjchem-2103	73	9	pef	pef	PROPN
eurjchem-2103	73	10	trp-134	trp-134	PROPN
eurjchem-2103	73	11	trp-212	trp-212	PROPN
eurjchem-2103	73	12	trp-134	trp-134	PROPN
eurjchem-2103	73	13	trp-212	trp-212	PROPN
eurjchem-2103	73	14	trp-134	trp-134	NOUN
eurjchem-2103	73	15	trp-212	trp-212	NOUN
eurjchem-2103	73	16	42.61	42.61	NUM
eurjchem-2103	73	17	48.87	48.87	NUM
eurjchem-2103	73	18	34.49	34.49	NUM
eurjchem-2103	73	19	49.36	49.36	NUM
eurjchem-2103	73	20	43.93	43.93	NUM
eurjchem-2103	73	21	49.32	49.32	NUM
eurjchem-2103	73	22	43.14	43.14	NUM
eurjchem-2103	73	23	53.99	53.99	NUM
eurjchem-2103	73	24	35.98	35.98	NUM
eurjchem-2103	73	25	45.14	45.14	NUM
eurjchem-2103	73	26	39.64	39.64	NUM
eurjchem-2103	73	27	49.72	49.72	NUM
eurjchem-2103	73	28	40.26	40.26	NUM
eurjchem-2103	73	29	52.96	52.96	NUM
eurjchem-2103	73	30	39.46	39.46	NUM
eurjchem-2103	73	31	49.97	49.97	NUM
eurjchem-2103	73	32	42.99	42.99	NUM
eurjchem-2103	73	33	46.85	46.85	NUM
eurjchem-2103	73	34	40.24	40.24	NUM
eurjchem-2103	73	35	44.88	44.88	NUM
eurjchem-2103	73	36	39.87	39.87	NUM
eurjchem-2103	73	37	40.07	40.07	NUM
eurjchem-2103	73	38	37.27	37.27	NUM
eurjchem-2103	73	39	45.57	45.57	NUM
eurjchem-2103	73	40	44.13	44.13	NUM
eurjchem-2103	73	41	43.32	43.32	NUM
eurjchem-2103	73	42	44.71	44.71	NUM
eurjchem-2103	73	43	40.19	40.19	NUM
eurjchem-2103	73	44	48.59	48.59	NUM
eurjchem-2103	73	45	50.33	50.33	NUM
eurjchem-2103	73	46	44.12	44.12	NUM
eurjchem-2103	73	47	53.50	53.50	NUM
eurjchem-2103	73	48	39.56	39.56	NUM
eurjchem-2103	73	49	50.00	50.00	NUM
eurjchem-2103	73	50	43.01	43.01	NUM
eurjchem-2103	73	51	45.54	45.54	NUM
eurjchem-2103	73	52	42.42	42.42	NUM
eurjchem-2103	73	53	*	*	SYM
eurjchem-2103	73	54	49.59	49.59	NUM
eurjchem-2103	73	55	*	*	PUNCT
eurjchem-2103	74	1	39.01	39.01	NUM
eurjchem-2103	74	2	*	*	SYM
eurjchem-2103	75	1	45.79	45.79	NUM
eurjchem-2103	75	2	*	*	SYM
eurjchem-2103	75	3	42.57	42.57	NUM
eurjchem-2103	75	4	*	*	PUNCT
eurjchem-2103	76	1	47.89	47.89	NUM
eurjchem-2103	76	2	*	*	PUNCT
eurjchem-2103	76	3	*	*	PUNCT
eurjchem-2103	76	4	docking	dock	VERB
eurjchem-2103	76	5	score	score	NOUN
eurjchem-2103	76	6	average	average	ADJ
eurjchem-2103	76	7	value	value	NOUN
eurjchem-2103	76	8	.	.	PUNCT
eurjchem-2103	77	1	figure	figure	NOUN
eurjchem-2103	77	2	2	2	NUM
eurjchem-2103	77	3	.	.	X
eurjchem-2103	77	4	crystallographic	crystallographic	ADJ
eurjchem-2103	77	5	bsa	bsa	PROPN
eurjchem-2103	77	6	structure	structure	NOUN
eurjchem-2103	77	7	(	(	PUNCT
eurjchem-2103	77	8	pdb	pdb	NOUN
eurjchem-2103	77	9	:	:	PUNCT
eurjchem-2103	77	10	4f5s	4f5s	NUM
eurjchem-2103	77	11	)	)	PUNCT
eurjchem-2103	77	12	highlighted	highlight	VERB
eurjchem-2103	77	13	the	the	DET
eurjchem-2103	77	14	three	three	NUM
eurjchem-2103	77	15	domains	domain	NOUN
eurjchem-2103	77	16	:	:	PUNCT
eurjchem-2103	77	17	i	i	PRON
eurjchem-2103	77	18	(	(	PUNCT
eurjchem-2103	77	19	yellow	yellow	ADJ
eurjchem-2103	77	20	)	)	PUNCT
eurjchem-2103	77	21	,	,	PUNCT
eurjchem-2103	77	22	ii	ii	PROPN
eurjchem-2103	77	23	(	(	PUNCT
eurjchem-2103	77	24	beige	beige	NOUN
eurjchem-2103	77	25	)	)	PUNCT
eurjchem-2103	77	26	,	,	PUNCT
eurjchem-2103	77	27	and	and	CCONJ
eurjchem-2103	77	28	iii	iii	X
eurjchem-2103	77	29	(	(	PUNCT
eurjchem-2103	77	30	orange	orange	PROPN
eurjchem-2103	77	31	)	)	PUNCT
eurjchem-2103	77	32	.	.	PUNCT
eurjchem-2103	78	1	the	the	DET
eurjchem-2103	78	2	internal	internal	ADJ
eurjchem-2103	78	3	tryptophan	tryptophan	NOUN
eurjchem-2103	78	4	residues	residue	NOUN
eurjchem-2103	78	5	were	be	AUX
eurjchem-2103	78	6	represented	represent	VERB
eurjchem-2103	78	7	as	as	ADP
eurjchem-2103	78	8	green	green	ADJ
eurjchem-2103	78	9	spheres	sphere	NOUN
eurjchem-2103	78	10	and	and	CCONJ
eurjchem-2103	78	11	hydration	hydration	NOUN
eurjchem-2103	78	12	molecules	molecule	NOUN
eurjchem-2103	78	13	are	be	AUX
eurjchem-2103	78	14	represented	represent	VERB
eurjchem-2103	78	15	as	as	ADP
eurjchem-2103	78	16	red	red	ADJ
eurjchem-2103	78	17	dots	dot	NOUN
eurjchem-2103	78	18	.	.	PUNCT
eurjchem-2103	79	1	in	in	ADP
eurjchem-2103	79	2	addition	addition	NOUN
eurjchem-2103	79	3	,	,	PUNCT
eurjchem-2103	79	4	the	the	DET
eurjchem-2103	79	5	experimental	experimental	ADJ
eurjchem-2103	79	6	number	number	NOUN
eurjchem-2103	79	7	of	of	ADP
eurjchem-2103	79	8	binding	bind	VERB
eurjchem-2103	79	9	sites	site	NOUN
eurjchem-2103	79	10	(	(	PUNCT
eurjchem-2103	79	11	n	n	NOUN
eurjchem-2103	79	12	~	~	PUNCT
eurjchem-2103	79	13	1.00	1.00	NUM
eurjchem-2103	79	14	)	)	PUNCT
eurjchem-2103	79	15	indicate	indicate	VERB
eurjchem-2103	79	16	that	that	SCONJ
eurjchem-2103	79	17	each	each	DET
eurjchem-2103	79	18	fluoroquinolone	fluoroquinolone	NOUN
eurjchem-2103	79	19	interacts	interact	VERB
eurjchem-2103	79	20	in	in	ADP
eurjchem-2103	79	21	the	the	DET
eurjchem-2103	79	22	ratio	ratio	NOUN
eurjchem-2103	79	23	of	of	ADP
eurjchem-2103	79	24	1:1	1:1	NUM
eurjchem-2103	79	25	,	,	PUNCT
eurjchem-2103	79	26	suggesting	suggest	VERB
eurjchem-2103	79	27	just	just	ADV
eurjchem-2103	79	28	one	one	NUM
eurjchem-2103	79	29	main	main	ADJ
eurjchem-2103	79	30	binding	bind	VERB
eurjchem-2103	79	31	site	site	NOUN
eurjchem-2103	79	32	in	in	ADP
eurjchem-2103	79	33	the	the	DET
eurjchem-2103	79	34	bsa	bsa	PROPN
eurjchem-2103	79	35	structure	structure	NOUN
eurjchem-2103	79	36	for	for	ADP
eurjchem-2103	79	37	cip	cip	NOUN
eurjchem-2103	79	38	,	,	PUNCT
eurjchem-2103	79	39	enr	enr	NOUN
eurjchem-2103	79	40	or	or	CCONJ
eurjchem-2103	79	41	pef	pef	NOUN
eurjchem-2103	80	1	[	[	X
eurjchem-2103	80	2	22	22	NUM
eurjchem-2103	80	3	-	-	SYM
eurjchem-2103	80	4	30	30	NUM
eurjchem-2103	80	5	]	]	PUNCT
eurjchem-2103	80	6	.	.	PUNCT
eurjchem-2103	81	1	from	from	ADP
eurjchem-2103	81	2	these	these	DET
eurjchem-2103	81	3	experimental	experimental	ADJ
eurjchem-2103	81	4	parameters	parameter	NOUN
eurjchem-2103	81	5	,	,	PUNCT
eurjchem-2103	81	6	the	the	DET
eurjchem-2103	81	7	molecular	molecular	ADJ
eurjchem-2103	81	8	docking	docking	NOUN
eurjchem-2103	81	9	calculations	calculation	NOUN
eurjchem-2103	81	10	were	be	AUX
eurjchem-2103	81	11	carried	carry	VERB
eurjchem-2103	81	12	out	out	ADP
eurjchem-2103	81	13	for	for	ADP
eurjchem-2103	81	14	bsa	bsa	PROPN
eurjchem-2103	81	15	:	:	PUNCT
eurjchem-2103	81	16	cip	cip	PROPN
eurjchem-2103	81	17	,	,	PUNCT
eurjchem-2103	81	18	bsa	bsa	PROPN
eurjchem-2103	81	19	:	:	PUNCT
eurjchem-2103	81	20	enr	enr	PROPN
eurjchem-2103	81	21	and	and	CCONJ
eurjchem-2103	81	22	bsa	bsa	PROPN
eurjchem-2103	81	23	:	:	PUNCT
eurjchem-2103	81	24	pef	pef	NOUN
eurjchem-2103	81	25	in	in	ADP
eurjchem-2103	81	26	the	the	DET
eurjchem-2103	81	27	trp-134	trp-134	NOUN
eurjchem-2103	81	28	and	and	CCONJ
eurjchem-2103	81	29	trp-212	trp-212	NOUN
eurjchem-2103	81	30	-	-	PUNCT
eurjchem-2103	81	31	containing	contain	VERB
eurjchem-2103	81	32	binding	bind	VERB
eurjchem-2103	81	33	sites	site	NOUN
eurjchem-2103	81	34	.	.	PUNCT
eurjchem-2103	82	1	the	the	DET
eurjchem-2103	82	2	approach	approach	NOUN
eurjchem-2103	82	3	used	use	VERB
eurjchem-2103	82	4	was	be	AUX
eurjchem-2103	82	5	to	to	PART
eurjchem-2103	82	6	split	split	VERB
eurjchem-2103	82	7	the	the	DET
eurjchem-2103	82	8	protein	protein	NOUN
eurjchem-2103	82	9	into	into	ADP
eurjchem-2103	82	10	multiple	multiple	ADJ
eurjchem-2103	82	11	binding	bind	VERB
eurjchem-2103	82	12	sites	site	NOUN
eurjchem-2103	82	13	and	and	CCONJ
eurjchem-2103	82	14	carry	carry	VERB
eurjchem-2103	82	15	out	out	ADP
eurjchem-2103	82	16	individual	individual	ADJ
eurjchem-2103	82	17	docking	docking	NOUN
eurjchem-2103	82	18	experiments	experiment	NOUN
eurjchem-2103	82	19	in	in	ADP
eurjchem-2103	82	20	each	each	DET
eurjchem-2103	82	21	binding	bind	VERB
eurjchem-2103	82	22	pocket	pocket	NOUN
eurjchem-2103	82	23	.	.	PUNCT
eurjchem-2103	83	1	the	the	DET
eurjchem-2103	83	2	molecular	molecular	ADJ
eurjchem-2103	83	3	docking	docking	NOUN
eurjchem-2103	83	4	calculations	calculation	NOUN
eurjchem-2103	83	5	were	be	AUX
eurjchem-2103	83	6	carried	carry	VERB
eurjchem-2103	83	7	out	out	ADP
eurjchem-2103	83	8	for	for	ADP
eurjchem-2103	83	9	trp-134and	trp-134and	NUM
eurjchem-2103	83	10	trp-212	trp-212	NOUN
eurjchem-2103	83	11	-	-	PUNCT
eurjchem-2103	83	12	containing	contain	VERB
eurjchem-2103	83	13	binding	bind	VERB
eurjchem-2103	83	14	sites	site	NOUN
eurjchem-2103	83	15	.	.	PUNCT
eurjchem-2103	84	1	table	table	NOUN
eurjchem-2103	84	2	1	1	NUM
eurjchem-2103	84	3	,	,	PUNCT
eurjchem-2103	84	4	shows	show	VERB
eurjchem-2103	84	5	the	the	DET
eurjchem-2103	84	6	fitness	fitness	NOUN
eurjchem-2103	84	7	scores	score	NOUN
eurjchem-2103	84	8	for	for	ADP
eurjchem-2103	84	9	the	the	DET
eurjchem-2103	84	10	ten	ten	NUM
eurjchem-2103	84	11	best	good	ADJ
eurjchem-2103	84	12	docking	docking	NOUN
eurjchem-2103	84	13	poses	pose	NOUN
eurjchem-2103	84	14	in	in	ADP
eurjchem-2103	84	15	both	both	PRON
eurjchem-2103	84	16	trp-134and	trp-134and	PROPN
eurjchem-2103	84	17	trp-212	trp-212	NOUN
eurjchem-2103	84	18	-	-	PUNCT
eurjchem-2103	84	19	containing	contain	VERB
eurjchem-2103	84	20	binding	bind	VERB
eurjchem-2103	84	21	sites	site	NOUN
eurjchem-2103	84	22	(	(	PUNCT
eurjchem-2103	84	23	chemplp	chemplp	NOUN
eurjchem-2103	84	24	function	function	NOUN
eurjchem-2103	84	25	)	)	PUNCT
eurjchem-2103	84	26	performed	perform	VERB
eurjchem-2103	84	27	on	on	ADP
eurjchem-2103	84	28	cip	cip	PROPN
eurjchem-2103	84	29	,	,	PUNCT
eurjchem-2103	84	30	enr	enr	PROPN
eurjchem-2103	84	31	and	and	CCONJ
eurjchem-2103	84	32	pef	pef	NOUN
eurjchem-2103	84	33	.	.	PUNCT
eurjchem-2103	85	1	the	the	DET
eurjchem-2103	85	2	docking	docking	NOUN
eurjchem-2103	85	3	score	score	NOUN
eurjchem-2103	85	4	average	average	ADJ
eurjchem-2103	85	5	suggests	suggest	VERB
eurjchem-2103	85	6	that	that	SCONJ
eurjchem-2103	85	7	all	all	DET
eurjchem-2103	85	8	three	three	NUM
eurjchem-2103	85	9	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	85	10	interact	interact	VERB
eurjchem-2103	85	11	satisfactorily	satisfactorily	ADV
eurjchem-2103	85	12	with	with	ADP
eurjchem-2103	85	13	bsa	bsa	PROPN
eurjchem-2103	85	14	into	into	ADP
eurjchem-2103	85	15	the	the	DET
eurjchem-2103	85	16	trp-212	trp-212	NOUN
eurjchem-2103	85	17	-	-	PUNCT
eurjchem-2103	85	18	containing	contain	VERB
eurjchem-2103	85	19	binding	bind	VERB
eurjchem-2103	85	20	site	site	NOUN
eurjchem-2103	85	21	than	than	ADP
eurjchem-2103	85	22	in	in	ADP
eurjchem-2103	85	23	the	the	DET
eurjchem-2103	85	24	trp-134	trp-134	NOUN
eurjchem-2103	85	25	-	-	PUNCT
eurjchem-2103	85	26	containing	contain	VERB
eurjchem-2103	85	27	binding	bind	VERB
eurjchem-2103	85	28	site	site	NOUN
eurjchem-2103	85	29	.	.	PUNCT
eurjchem-2103	86	1	to	to	PART
eurjchem-2103	86	2	find	find	VERB
eurjchem-2103	86	3	a	a	DET
eurjchem-2103	86	4	statistically	statistically	ADV
eurjchem-2103	86	5	significant	significant	ADJ
eurjchem-2103	86	6	difference	difference	NOUN
eurjchem-2103	86	7	from	from	ADP
eurjchem-2103	86	8	the	the	DET
eurjchem-2103	86	9	theoretical	theoretical	ADJ
eurjchem-2103	86	10	results	result	NOUN
eurjchem-2103	86	11	,	,	PUNCT
eurjchem-2103	86	12	it	it	PRON
eurjchem-2103	86	13	was	be	AUX
eurjchem-2103	86	14	applied	apply	VERB
eurjchem-2103	86	15	student	student	NOUN
eurjchem-2103	86	16	's	's	PART
eurjchem-2103	86	17	t	t	NOUN
eurjchem-2103	86	18	-	-	PUNCT
eurjchem-2103	86	19	test	test	NOUN
eurjchem-2103	86	20	:	:	PUNCT
eurjchem-2103	86	21	as	as	ADP
eurjchem-2103	86	22	the	the	DET
eurjchem-2103	86	23	p	p	PROPN
eurjchem-2103	86	24	values	value	NOUN
eurjchem-2103	86	25	for	for	ADP
eurjchem-2103	86	26	the	the	DET
eurjchem-2103	86	27	three	three	NUM
eurjchem-2103	86	28	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	86	29	(	(	PUNCT
eurjchem-2103	86	30	1.24×10	1.24×10	NUM
eurjchem-2103	86	31	-	-	SYM
eurjchem-2103	86	32	2	2	NUM
eurjchem-2103	86	33	,	,	PUNCT
eurjchem-2103	86	34	2.07×10	2.07×10	NUM
eurjchem-2103	86	35	-	-	SYM
eurjchem-2103	86	36	2	2	NUM
eurjchem-2103	86	37	,	,	PUNCT
eurjchem-2103	86	38	and	and	CCONJ
eurjchem-2103	86	39	1.89×10	1.89×10	NUM
eurjchem-2103	86	40	-	-	SYM
eurjchem-2103	86	41	2	2	NUM
eurjchem-2103	86	42	,	,	PUNCT
eurjchem-2103	86	43	for	for	ADP
eurjchem-2103	86	44	cip	cip	NOUN
eurjchem-2103	86	45	,	,	PUNCT
eurjchem-2103	86	46	enr	enr	PROPN
eurjchem-2103	86	47	and	and	CCONJ
eurjchem-2103	86	48	pef	pef	NOUN
eurjchem-2103	86	49	,	,	PUNCT
eurjchem-2103	86	50	respectively	respectively	ADV
eurjchem-2103	86	51	)	)	PUNCT
eurjchem-2103	86	52	are	be	AUX
eurjchem-2103	86	53	less	less	ADJ
eurjchem-2103	86	54	than	than	ADP
eurjchem-2103	86	55	5.00×10	5.00×10	NUM
eurjchem-2103	86	56	-	-	SYM
eurjchem-2103	86	57	2	2	NUM
eurjchem-2103	86	58	(	(	PUNCT
eurjchem-2103	86	59	95.0	95.0	NUM
eurjchem-2103	86	60	%	%	NOUN
eurjchem-2103	86	61	confidence	confidence	NOUN
eurjchem-2103	86	62	interval	interval	NOUN
eurjchem-2103	86	63	)	)	PUNCT
eurjchem-2103	86	64	,	,	PUNCT
eurjchem-2103	86	65	can	can	AUX
eurjchem-2103	86	66	reject	reject	VERB
eurjchem-2103	86	67	the	the	DET
eurjchem-2103	86	68	null	null	ADJ
eurjchem-2103	86	69	hypothesis	hypothesis	NOUN
eurjchem-2103	86	70	,	,	PUNCT
eurjchem-2103	86	71	indicating	indicate	VERB
eurjchem-2103	86	72	a	a	DET
eurjchem-2103	86	73	statistically	statistically	ADV
eurjchem-2103	86	74	significant	significant	ADJ
eurjchem-2103	86	75	difference	difference	NOUN
eurjchem-2103	86	76	between	between	ADP
eurjchem-2103	86	77	the	the	DET
eurjchem-2103	86	78	two	two	NUM
eurjchem-2103	86	79	protein	protein	NOUN
eurjchem-2103	86	80	binding	bind	VERB
eurjchem-2103	86	81	sites	site	NOUN
eurjchem-2103	86	82	(	(	PUNCT
eurjchem-2103	86	83	trp-134and	trp-134and	CCONJ
eurjchem-2103	86	84	trp-212containing	trp-212containe	VERB
eurjchem-2103	86	85	binding	bind	VERB
eurjchem-2103	86	86	sites	site	NOUN
eurjchem-2103	86	87	)	)	PUNCT
eurjchem-2103	87	1	[	[	X
eurjchem-2103	87	2	37	37	NUM
eurjchem-2103	87	3	]	]	PUNCT
eurjchem-2103	87	4	.	.	PUNCT
eurjchem-2103	88	1	usually	usually	ADV
eurjchem-2103	88	2	,	,	PUNCT
eurjchem-2103	88	3	the	the	DET
eurjchem-2103	88	4	literature	literature	NOUN
eurjchem-2103	88	5	reveals	reveal	VERB
eurjchem-2103	88	6	that	that	SCONJ
eurjchem-2103	88	7	the	the	DET
eurjchem-2103	88	8	ligands	ligand	NOUN
eurjchem-2103	88	9	which	which	PRON
eurjchem-2103	88	10	interact	interact	VERB
eurjchem-2103	88	11	preferentially	preferentially	ADV
eurjchem-2103	88	12	in	in	ADP
eurjchem-2103	88	13	the	the	DET
eurjchem-2103	88	14	site	site	NOUN
eurjchem-2103	88	15	i	i	PRON
eurjchem-2103	88	16	are	be	AUX
eurjchem-2103	88	17	composed	compose	VERB
eurjchem-2103	88	18	by	by	ADP
eurjchem-2103	88	19	carboxylic	carboxylic	ADJ
eurjchem-2103	88	20	acid	acid	NOUN
eurjchem-2103	88	21	groups	group	NOUN
eurjchem-2103	88	22	and/or	and/or	CCONJ
eurjchem-2103	88	23	bulky	bulky	ADJ
eurjchem-2103	88	24	heterocyclic	heterocyclic	ADJ
eurjchem-2103	88	25	molecules	molecule	NOUN
eurjchem-2103	88	26	dominated	dominate	VERB
eurjchem-2103	88	27	by	by	ADP
eurjchem-2103	88	28	a	a	DET
eurjchem-2103	88	29	negative	negative	ADJ
eurjchem-2103	88	30	charge	charge	NOUN
eurjchem-2103	88	31	or	or	CCONJ
eurjchem-2103	88	32	containing	contain	VERB
eurjchem-2103	88	33	azo	azo	NOUN
eurjchem-2103	88	34	and/or	and/or	CCONJ
eurjchem-2103	88	35	sulfur	sulfur	NOUN
eurjchem-2103	88	36	groups	group	NOUN
eurjchem-2103	88	37	(	(	PUNCT
eurjchem-2103	88	38	e.g.	e.g.	ADV
eurjchem-2103	88	39	phenylbutazone	phenylbutazone	NOUN
eurjchem-2103	88	40	,	,	PUNCT
eurjchem-2103	88	41	azapropazone	azapropazone	NOUN
eurjchem-2103	88	42	,	,	PUNCT
eurjchem-2103	88	43	tolbutamide	tolbutamide	NOUN
eurjchem-2103	88	44	,	,	PUNCT
eurjchem-2103	88	45	bucolome	bucolome	NOUN
eurjchem-2103	88	46	and	and	CCONJ
eurjchem-2103	88	47	sulfisoxazole	sulfisoxazole	ADJ
eurjchem-2103	88	48	)	)	PUNCT
eurjchem-2103	88	49	rich	rich	ADJ
eurjchem-2103	88	50	in	in	ADP
eurjchem-2103	88	51	non	non	ADJ
eurjchem-2103	88	52	-	-	ADJ
eurjchem-2103	88	53	ligand	ligand	ADJ
eurjchem-2103	88	54	p	p	NOUN
eurjchem-2103	88	55	pair	pair	NOUN
eurjchem-2103	88	56	and	and	CCONJ
eurjchem-2103	88	57	π	π	NOUN
eurjchem-2103	88	58	electrons	electron	NOUN
eurjchem-2103	88	59	[	[	X
eurjchem-2103	88	60	38,39	38,39	NOUN
eurjchem-2103	88	61	]	]	X
eurjchem-2103	88	62	,	,	PUNCT
eurjchem-2103	88	63	whose	whose	DET
eurjchem-2103	88	64	shows	show	VERB
eurjchem-2103	88	65	structural	structural	ADJ
eurjchem-2103	88	66	similarity	similarity	NOUN
eurjchem-2103	88	67	characteristics	characteristic	NOUN
eurjchem-2103	88	68	to	to	ADP
eurjchem-2103	88	69	those	those	PRON
eurjchem-2103	88	70	in	in	ADP
eurjchem-2103	88	71	the	the	DET
eurjchem-2103	88	72	three	three	NUM
eurjchem-2103	88	73	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	88	74	under	under	ADP
eurjchem-2103	88	75	study	study	NOUN
eurjchem-2103	88	76	.	.	PUNCT
eurjchem-2103	89	1	with	with	ADP
eurjchem-2103	89	2	the	the	DET
eurjchem-2103	89	3	intention	intention	NOUN
eurjchem-2103	89	4	of	of	ADP
eurjchem-2103	89	5	offer	offer	NOUN
eurjchem-2103	89	6	a	a	DET
eurjchem-2103	89	7	molecular	molecular	ADJ
eurjchem-2103	89	8	description	description	NOUN
eurjchem-2103	89	9	of	of	ADP
eurjchem-2103	89	10	the	the	DET
eurjchem-2103	89	11	binding	binding	NOUN
eurjchem-2103	89	12	between	between	ADP
eurjchem-2103	89	13	bsa	bsa	NOUN
eurjchem-2103	89	14	and	and	CCONJ
eurjchem-2103	89	15	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	89	16	inside	inside	ADP
eurjchem-2103	89	17	the	the	DET
eurjchem-2103	89	18	trp-212containing	trp-212containe	VERB
eurjchem-2103	89	19	binding	bind	VERB
eurjchem-2103	89	20	site	site	NOUN
eurjchem-2103	89	21	,	,	PUNCT
eurjchem-2103	89	22	as	as	ADV
eurjchem-2103	89	23	well	well	ADV
eurjchem-2103	89	24	as	as	ADP
eurjchem-2103	89	25	suggesting	suggest	VERB
eurjchem-2103	89	26	the	the	DET
eurjchem-2103	89	27	main	main	ADJ
eurjchem-2103	89	28	amino	amino	NOUN
eurjchem-2103	89	29	acid	acid	NOUN
eurjchem-2103	89	30	residues	residue	NOUN
eurjchem-2103	89	31	and	and	CCONJ
eurjchem-2103	89	32	the	the	DET
eurjchem-2103	89	33	main	main	ADJ
eurjchem-2103	89	34	chemical	chemical	NOUN
eurjchem-2103	89	35	binding	bind	VERB
eurjchem-2103	89	36	force	force	NOUN
eurjchem-2103	89	37	directly	directly	ADV
eurjchem-2103	89	38	involved	involve	VERB
eurjchem-2103	89	39	on	on	ADP
eurjchem-2103	89	40	the	the	DET
eurjchem-2103	89	41	interaction	interaction	NOUN
eurjchem-2103	89	42	,	,	PUNCT
eurjchem-2103	89	43	the	the	DET
eurjchem-2103	89	44	highest	high	ADJ
eurjchem-2103	89	45	docking	docking	NOUN
eurjchem-2103	89	46	score	score	NOUN
eurjchem-2103	89	47	value	value	NOUN
eurjchem-2103	89	48	of	of	ADP
eurjchem-2103	89	49	each	each	DET
eurjchem-2103	89	50	fluoroquinolone	fluoroquinolone	NOUN
eurjchem-2103	89	51	was	be	AUX
eurjchem-2103	89	52	analyzed	analyze	VERB
eurjchem-2103	89	53	individually	individually	ADV
eurjchem-2103	89	54	.	.	PUNCT
eurjchem-2103	90	1	figure	figure	VERB
eurjchem-2103	90	2	3	3	NUM
eurjchem-2103	90	3	depicts	depict	VERB
eurjchem-2103	90	4	the	the	DET
eurjchem-2103	90	5	best	good	ADJ
eurjchem-2103	90	6	docking	docking	NOUN
eurjchem-2103	90	7	pose	pose	VERB
eurjchem-2103	90	8	for	for	ADP
eurjchem-2103	90	9	the	the	DET
eurjchem-2103	90	10	three	three	NUM
eurjchem-2103	90	11	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	90	12	into	into	ADP
eurjchem-2103	90	13	site	site	NOUN
eurjchem-2103	90	14	i	i	PRON
eurjchem-2103	90	15	and	and	CCONJ
eurjchem-2103	90	16	table	table	NOUN
eurjchem-2103	90	17	2	2	NUM
eurjchem-2103	90	18	shows	show	VERB
eurjchem-2103	90	19	the	the	DET
eurjchem-2103	90	20	main	main	ADJ
eurjchem-2103	90	21	amino	amino	NOUN
eurjchem-2103	90	22	acid	acid	NOUN
eurjchem-2103	90	23	residues	residue	NOUN
eurjchem-2103	90	24	involved	involve	VERB
eurjchem-2103	90	25	in	in	ADP
eurjchem-2103	90	26	the	the	DET
eurjchem-2103	90	27	interaction	interaction	NOUN
eurjchem-2103	90	28	of	of	ADP
eurjchem-2103	90	29	bsa	bsa	PROPN
eurjchem-2103	90	30	:	:	PUNCT
eurjchem-2103	90	31	cip	cip	PROPN
eurjchem-2103	90	32	,	,	PUNCT
eurjchem-2103	90	33	bsa	bsa	PROPN
eurjchem-2103	90	34	:	:	PUNCT
eurjchem-2103	90	35	enr	enr	PROPN
eurjchem-2103	90	36	,	,	PUNCT
eurjchem-2103	90	37	and	and	CCONJ
eurjchem-2103	90	38	bsa	bsa	PROPN
eurjchem-2103	90	39	:	:	PUNCT
eurjchem-2103	91	1	pef	pef	NOUN
eurjchem-2103	91	2	.	.	PROPN
eurjchem-2103	91	3	molecular	molecular	ADJ
eurjchem-2103	91	4	docking	docking	NOUN
eurjchem-2103	91	5	results	result	NOUN
eurjchem-2103	91	6	suggested	suggest	VERB
eurjchem-2103	91	7	hydrogen	hydrogen	NOUN
eurjchem-2103	91	8	bonding	bonding	NOUN
eurjchem-2103	91	9	and	and	CCONJ
eurjchem-2103	91	10	van	van	PROPN
eurjchem-2103	91	11	der	der	NOUN
eurjchem-2103	91	12	waals	waal	NOUN
eurjchem-2103	91	13	interactions	interaction	NOUN
eurjchem-2103	91	14	as	as	ADP
eurjchem-2103	91	15	the	the	DET
eurjchem-2103	91	16	main	main	ADJ
eurjchem-2103	91	17	intermolecular	intermolecular	ADJ
eurjchem-2103	91	18	forces	force	NOUN
eurjchem-2103	91	19	responsible	responsible	ADJ
eurjchem-2103	91	20	for	for	ADP
eurjchem-2103	91	21	the	the	DET
eurjchem-2103	91	22	complex	complex	ADJ
eurjchem-2103	91	23	stabilization	stabilization	NOUN
eurjchem-2103	91	24	for	for	ADP
eurjchem-2103	91	25	all	all	DET
eurjchem-2103	91	26	studied	study	VERB
eurjchem-2103	91	27	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	91	28	.	.	PUNCT
eurjchem-2103	92	1	in	in	ADP
eurjchem-2103	92	2	general	general	ADJ
eurjchem-2103	92	3	,	,	PUNCT
eurjchem-2103	92	4	van	van	PROPN
eurjchem-2103	92	5	der	der	NOUN
eurjchem-2103	92	6	waals	waal	NOUN
eurjchem-2103	92	7	and	and	CCONJ
eurjchem-2103	92	8	hydrogen	hydrogen	NOUN
eurjchem-2103	92	9	bonding	bonding	NOUN
eurjchem-2103	92	10	are	be	AUX
eurjchem-2103	92	11	the	the	DET
eurjchem-2103	92	12	main	main	ADJ
eurjchem-2103	92	13	binding	bind	VERB
eurjchem-2103	92	14	forces	force	NOUN
eurjchem-2103	92	15	which	which	PRON
eurjchem-2103	92	16	contribute	contribute	VERB
eurjchem-2103	92	17	to	to	ADP
eurjchem-2103	92	18	interactions	interaction	NOUN
eurjchem-2103	92	19	between	between	ADP
eurjchem-2103	92	20	proteins	protein	NOUN
eurjchem-2103	92	21	and	and	CCONJ
eurjchem-2103	92	22	small	small	ADJ
eurjchem-2103	92	23	organic	organic	ADJ
eurjchem-2103	92	24	molecules	molecule	NOUN
eurjchem-2103	92	25	.	.	PUNCT
eurjchem-2103	93	1	however	however	ADV
eurjchem-2103	93	2	,	,	PUNCT
eurjchem-2103	93	3	the	the	DET
eurjchem-2103	93	4	first	first	ADJ
eurjchem-2103	93	5	one	one	NOUN
eurjchem-2103	93	6	is	be	AUX
eurjchem-2103	93	7	usually	usually	ADV
eurjchem-2103	93	8	estimated	estimate	VERB
eurjchem-2103	93	9	based	base	VERB
eurjchem-2103	93	10	on	on	ADP
eurjchem-2103	93	11	idealized	idealized	ADJ
eurjchem-2103	93	12	models	model	NOUN
eurjchem-2103	93	13	of	of	ADP
eurjchem-2103	93	14	the	the	DET
eurjchem-2103	93	15	molecular	molecular	ADJ
eurjchem-2103	93	16	geometry	geometry	NOUN
eurjchem-2103	93	17	,	,	PUNCT
eurjchem-2103	93	18	e.g.	e.g.	ADV
eurjchem-2103	93	19	,	,	PUNCT
eurjchem-2103	93	20	spheres	sphere	NOUN
eurjchem-2103	93	21	or	or	CCONJ
eurjchem-2103	93	22	spheroids	spheroid	NOUN
eurjchem-2103	93	23	,	,	PUNCT
eurjchem-2103	93	24	involving	involve	VERB
eurjchem-2103	93	25	less	less	ADJ
eurjchem-2103	93	26	energy	energy	NOUN
eurjchem-2103	93	27	when	when	SCONJ
eurjchem-2103	93	28	compared	compare	VERB
eurjchem-2103	93	29	to	to	ADP
eurjchem-2103	93	30	hydrogen	hydrogen	NOUN
eurjchem-2103	93	31	bonding	bonding	NOUN
eurjchem-2103	93	32	(	(	PUNCT
eurjchem-2103	93	33	energies	energy	NOUN
eurjchem-2103	93	34	associated	associate	VERB
eurjchem-2103	93	35	with	with	ADP
eurjchem-2103	93	36	hydrogen	hydrogen	NOUN
eurjchem-2103	93	37	bonds	bond	NOUN
eurjchem-2103	93	38	are	be	AUX
eurjchem-2103	93	39	in	in	ADP
eurjchem-2103	93	40	the	the	DET
eurjchem-2103	93	41	range	range	NOUN
eurjchem-2103	93	42	of	of	ADP
eurjchem-2103	93	43	630	630	NUM
eurjchem-2103	93	44	kj	kj	PROPN
eurjchem-2103	93	45	/	/	SYM
eurjchem-2103	93	46	mol	mol	PROPN
eurjchem-2103	94	1	(	(	PUNCT
eurjchem-2103	94	2	≈	≈	PROPN
eurjchem-2103	94	3	2	2	NUM
eurjchem-2103	94	4	-	-	SYM
eurjchem-2103	94	5	12	12	NUM
eurjchem-2103	94	6	kbt	kbt	NOUN
eurjchem-2103	94	7	)	)	PUNCT
eurjchem-2103	95	1	[	[	X
eurjchem-2103	95	2	40	40	NUM
eurjchem-2103	95	3	-	-	SYM
eurjchem-2103	95	4	43	43	NUM
eurjchem-2103	95	5	]	]	PUNCT
eurjchem-2103	95	6	.	.	PUNCT
eurjchem-2103	96	1	since	since	SCONJ
eurjchem-2103	96	2	enr	enr	PROPN
eurjchem-2103	96	3	presented	present	VERB
eurjchem-2103	96	4	just	just	ADV
eurjchem-2103	96	5	one	one	NUM
eurjchem-2103	96	6	interaction	interaction	NOUN
eurjchem-2103	96	7	via	via	ADP
eurjchem-2103	96	8	hydrogen	hydrogen	NOUN
eurjchem-2103	96	9	bonding	bonding	NOUN
eurjchem-2103	96	10	(	(	PUNCT
eurjchem-2103	96	11	with	with	ADP
eurjchem-2103	96	12	arg-194	arg-194	NOUN
eurjchem-2103	96	13	residue	residue	NOUN
eurjchem-2103	96	14	in	in	ADP
eurjchem-2103	96	15	a	a	DET
eurjchem-2103	96	16	distance	distance	NOUN
eurjchem-2103	96	17	of	of	ADP
eurjchem-2103	96	18	3.10	3.10	NUM
eurjchem-2103	96	19	å	å	NOUN
eurjchem-2103	96	20	)	)	PUNCT
eurjchem-2103	96	21	compared	compare	VERB
eurjchem-2103	96	22	to	to	ADP
eurjchem-2103	96	23	three	three	NUM
eurjchem-2103	96	24	for	for	ADP
eurjchem-2103	96	25	the	the	DET
eurjchem-2103	96	26	other	other	ADJ
eurjchem-2103	96	27	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	96	28	(	(	PUNCT
eurjchem-2103	96	29	arg-194	arg-194	PROPN
eurjchem-2103	96	30	,	,	PUNCT
eurjchem-2103	96	31	arg-217	arg-217	NOUN
eurjchem-2103	96	32	,	,	PUNCT
eurjchem-2103	96	33	and	and	CCONJ
eurjchem-2103	96	34	ser-343	ser-343	NOUN
eurjchem-2103	96	35	residues	residue	NOUN
eurjchem-2103	96	36	for	for	ADP
eurjchem-2103	96	37	cip	cip	NOUN
eurjchem-2103	96	38	within	within	ADP
eurjchem-2103	96	39	a	a	DET
eurjchem-2103	96	40	distance	distance	NOUN
eurjchem-2103	96	41	of	of	ADP
eurjchem-2103	96	42	3.30	3.30	NUM
eurjchem-2103	96	43	,	,	PUNCT
eurjchem-2103	96	44	3.30	3.30	NUM
eurjchem-2103	96	45	,	,	PUNCT
eurjchem-2103	96	46	and	and	CCONJ
eurjchem-2103	96	47	1.70	1.70	NUM
eurjchem-2103	96	48	å	å	NOUN
eurjchem-2103	96	49	,	,	PUNCT
eurjchem-2103	96	50	respectively	respectively	ADV
eurjchem-2103	96	51	,	,	PUNCT
eurjchem-2103	96	52	and	and	CCONJ
eurjchem-2103	96	53	arg-198	arg-198	NOUN
eurjchem-2103	96	54	,	,	PUNCT
eurjchem-2103	96	55	trp-212	trp-212	NOUN
eurjchem-2103	96	56	,	,	PUNCT
eurjchem-2103	96	57	and	and	CCONJ
eurjchem-2103	96	58	ser-343	ser-343	NOUN
eurjchem-2103	96	59	residues	residue	NOUN
eurjchem-2103	96	60	for	for	ADP
eurjchem-2103	96	61	pef	pef	NOUN
eurjchem-2103	96	62	within	within	ADP
eurjchem-2103	96	63	a	a	DET
eurjchem-2103	96	64	distance	distance	NOUN
eurjchem-2103	96	65	of	of	ADP
eurjchem-2103	96	66	3.80	3.80	NUM
eurjchem-2103	96	67	,	,	PUNCT
eurjchem-2103	96	68	3.20	3.20	NUM
eurjchem-2103	96	69	,	,	PUNCT
eurjchem-2103	96	70	and	and	CCONJ
eurjchem-2103	96	71	2.80	2.80	NUM
eurjchem-2103	96	72	å	å	NOUN
eurjchem-2103	96	73	,	,	PUNCT
eurjchem-2103	96	74	respectively	respectively	ADV
eurjchem-2103	96	75	)	)	PUNCT
eurjchem-2103	96	76	,	,	PUNCT
eurjchem-2103	96	77	there	there	PRON
eurjchem-2103	96	78	is	be	VERB
eurjchem-2103	96	79	an	an	DET
eurjchem-2103	96	80	indicative	indicative	ADJ
eurjchem-2103	96	81	that	that	SCONJ
eurjchem-2103	96	82	enr	enr	PROPN
eurjchem-2103	96	83	has	have	VERB
eurjchem-2103	96	84	weaker	weak	ADJ
eurjchem-2103	96	85	interaction	interaction	NOUN
eurjchem-2103	96	86	toward	toward	ADP
eurjchem-2103	96	87	bsa	bsa	PROPN
eurjchem-2103	96	88	than	than	ADP
eurjchem-2103	96	89	cip	cip	NOUN
eurjchem-2103	96	90	and	and	CCONJ
eurjchem-2103	96	91	pef	pef	PROPN
eurjchem-2103	96	92	[	[	X
eurjchem-2103	96	93	44	44	NUM
eurjchem-2103	96	94	]	]	PUNCT
eurjchem-2103	96	95	.	.	PUNCT
eurjchem-2103	97	1	to	to	PART
eurjchem-2103	97	2	clarify	clarify	VERB
eurjchem-2103	97	3	,	,	PUNCT
eurjchem-2103	97	4	the	the	DET
eurjchem-2103	97	5	hydrogen	hydrogen	NOUN
eurjchem-2103	97	6	from	from	ADP
eurjchem-2103	97	7	guanidinium	guanidinium	NOUN
eurjchem-2103	97	8	group	group	NOUN
eurjchem-2103	97	9	of	of	ADP
eurjchem-2103	97	10	the	the	DET
eurjchem-2103	97	11	arg194	arg194	PROPN
eurjchem-2103	97	12	and	and	CCONJ
eurjchem-2103	97	13	arg-217	arg-217	ADJ
eurjchem-2103	97	14	residues	residue	NOUN
eurjchem-2103	97	15	are	be	AUX
eurjchem-2103	97	16	potential	potential	ADJ
eurjchem-2103	97	17	donors	donor	NOUN
eurjchem-2103	97	18	to	to	PART
eurjchem-2103	97	19	form	form	VERB
eurjchem-2103	97	20	hydrogen	hydrogen	NOUN
eurjchem-2103	97	21	bonding	bonding	NOUN
eurjchem-2103	97	22	appropriately	appropriately	ADV
eurjchem-2103	97	23	with	with	ADP
eurjchem-2103	97	24	the	the	DET
eurjchem-2103	97	25	nitrogen	nitrogen	NOUN
eurjchem-2103	97	26	atoms	atom	NOUN
eurjchem-2103	97	27	from	from	ADP
eurjchem-2103	97	28	cip	cip	NOUN
eurjchem-2103	97	29	structure	structure	NOUN
eurjchem-2103	97	30	,	,	PUNCT
eurjchem-2103	97	31	within	within	ADP
eurjchem-2103	97	32	a	a	DET
eurjchem-2103	97	33	distance	distance	NOUN
eurjchem-2103	97	34	of	of	ADP
eurjchem-2103	97	35	3.30	3.30	NUM
eurjchem-2103	97	36	å	å	NOUN
eurjchem-2103	97	37	in	in	ADP
eurjchem-2103	97	38	both	both	DET
eurjchem-2103	97	39	cases	case	NOUN
eurjchem-2103	97	40	.	.	PUNCT
eurjchem-2103	98	1	the	the	DET
eurjchem-2103	98	2	particular	particular	ADJ
eurjchem-2103	98	3	interaction	interaction	NOUN
eurjchem-2103	98	4	of	of	ADP
eurjchem-2103	98	5	hydrogen	hydrogen	NOUN
eurjchem-2103	98	6	from	from	ADP
eurjchem-2103	98	7	-oh	-oh	NOUN
eurjchem-2103	98	8	group	group	NOUN
eurjchem-2103	98	9	in	in	ADP
eurjchem-2103	98	10	the	the	DET
eurjchem-2103	98	11	ser343	ser343	NOUN
eurjchem-2103	98	12	residue	residue	NOUN
eurjchem-2103	98	13	is	be	AUX
eurjchem-2103	98	14	also	also	ADV
eurjchem-2103	98	15	a	a	DET
eurjchem-2103	98	16	strong	strong	ADJ
eurjchem-2103	98	17	potential	potential	ADJ
eurjchem-2103	98	18	donor	donor	NOUN
eurjchem-2103	98	19	for	for	ADP
eurjchem-2103	98	20	hydrogen	hydrogen	NOUN
eurjchem-2103	98	21	bonding	bonding	NOUN
eurjchem-2103	98	22	with	with	ADP
eurjchem-2103	98	23	oxygen	oxygen	NOUN
eurjchem-2103	98	24	from	from	ADP
eurjchem-2103	98	25	carboxyl	carboxyl	NOUN
eurjchem-2103	98	26	group	group	NOUN
eurjchem-2103	98	27	of	of	ADP
eurjchem-2103	98	28	cip	cip	NOUN
eurjchem-2103	98	29	structure	structure	NOUN
eurjchem-2103	98	30	within	within	ADP
eurjchem-2103	98	31	a	a	DET
eurjchem-2103	98	32	distance	distance	NOUN
eurjchem-2103	98	33	of	of	ADP
eurjchem-2103	98	34	1.70	1.70	NUM
eurjchem-2103	98	35	å	å	NOUN
eurjchem-2103	98	36	,	,	PUNCT
eurjchem-2103	98	37	showing	show	VERB
eurjchem-2103	98	38	a	a	DET
eurjchem-2103	98	39	strong	strong	ADJ
eurjchem-2103	98	40	covalent	covalent	NOUN
eurjchem-2103	98	41	character	character	NOUN
eurjchem-2103	98	42	[	[	X
eurjchem-2103	98	43	43	43	NUM
eurjchem-2103	98	44	]	]	PUNCT
eurjchem-2103	98	45	.	.	PUNCT
eurjchem-2103	99	1	the	the	DET
eurjchem-2103	99	2	description	description	NOUN
eurjchem-2103	99	3	of	of	ADP
eurjchem-2103	99	4	the	the	DET
eurjchem-2103	99	5	interaction	interaction	NOUN
eurjchem-2103	99	6	via	via	ADP
eurjchem-2103	99	7	van	van	PROPN
eurjchem-2103	99	8	der	der	PROPN
eurjchem-2103	99	9	waals	waal	NOUN
eurjchem-2103	99	10	forces	force	NOUN
eurjchem-2103	99	11	was	be	AUX
eurjchem-2103	99	12	also	also	ADV
eurjchem-2103	99	13	suggested	suggest	VERB
eurjchem-2103	99	14	between	between	ADP
eurjchem-2103	99	15	cip	cip	NOUN
eurjchem-2103	99	16	and	and	CCONJ
eurjchem-2103	99	17	four	four	NUM
eurjchem-2103	99	18	kinds	kind	NOUN
eurjchem-2103	99	19	of	of	ADP
eurjchem-2103	99	20	amino	amino	NOUN
eurjchem-2103	99	21	acid	acid	NOUN
eurjchem-2103	99	22	residues	residue	NOUN
eurjchem-2103	99	23	:	:	PUNCT
eurjchem-2103	99	24	leu-197	leu-197	NOUN
eurjchem-2103	99	25	,	,	PUNCT
eurjchem-2103	99	26	arg-198	arg-198	NOUN
eurjchem-2103	99	27	,	,	PUNCT
eurjchem-2103	99	28	trp-212	trp-212	NOUN
eurjchem-2103	99	29	,	,	PUNCT
eurjchem-2103	99	30	and	and	CCONJ
eurjchem-2103	99	31	lys-294	lys-294	NOUN
eurjchem-2103	99	32	,	,	PUNCT
eurjchem-2103	99	33	within	within	ADP
eurjchem-2103	99	34	a	a	DET
eurjchem-2103	99	35	distance	distance	NOUN
eurjchem-2103	99	36	of	of	ADP
eurjchem-2103	99	37	2.80	2.80	NUM
eurjchem-2103	99	38	,	,	PUNCT
eurjchem-2103	99	39	3.50	3.50	NUM
eurjchem-2103	99	40	,	,	PUNCT
eurjchem-2103	99	41	2.00	2.00	NUM
eurjchem-2103	99	42	,	,	PUNCT
eurjchem-2103	99	43	and	and	CCONJ
eurjchem-2103	99	44	2.60	2.60	NUM
eurjchem-2103	99	45	å	å	NOUN
eurjchem-2103	99	46	,	,	PUNCT
eurjchem-2103	99	47	respectively	respectively	ADV
eurjchem-2103	99	48	.	.	PUNCT
eurjchem-2103	100	1	overall	overall	ADJ
eurjchem-2103	100	2	,	,	PUNCT
eurjchem-2103	100	3	all	all	DET
eurjchem-2103	100	4	the	the	DET
eurjchem-2103	100	5	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	100	6	studied	study	VERB
eurjchem-2103	100	7	in	in	ADP
eurjchem-2103	100	8	this	this	DET
eurjchem-2103	100	9	work	work	NOUN
eurjchem-2103	100	10	showed	show	VERB
eurjchem-2103	100	11	remarkable	remarkable	ADJ
eurjchem-2103	100	12	theoretical	theoretical	ADJ
eurjchem-2103	100	13	binding	bind	VERB
eurjchem-2103	100	14	capacity	capacity	NOUN
eurjchem-2103	100	15	mainly	mainly	ADV
eurjchem-2103	100	16	related	relate	VERB
eurjchem-2103	100	17	with	with	ADP
eurjchem-2103	100	18	trp-212	trp-212	ADJ
eurjchem-2103	100	19	residue	residue	NOUN
eurjchem-2103	100	20	in	in	ADP
eurjchem-2103	100	21	domain	domain	NOUN
eurjchem-2103	100	22	ii	ii	NOUN
eurjchem-2103	100	23	,	,	PUNCT
eurjchem-2103	100	24	however	however	ADV
eurjchem-2103	100	25	,	,	PUNCT
eurjchem-2103	100	26	the	the	DET
eurjchem-2103	100	27	slight	slight	ADJ
eurjchem-2103	100	28	structural	structural	ADJ
eurjchem-2103	100	29	differences	difference	NOUN
eurjchem-2103	100	30	presented	present	VERB
eurjchem-2103	100	31	among	among	ADP
eurjchem-2103	100	32	the	the	DET
eurjchem-2103	100	33	three	three	NUM
eurjchem-2103	100	34	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	100	35	drove	drive	VERB
eurjchem-2103	100	36	influences	influence	NOUN
eurjchem-2103	100	37	on	on	ADP
eurjchem-2103	100	38	the	the	DET
eurjchem-2103	100	39	interaction	interaction	NOUN
eurjchem-2103	100	40	toward	toward	ADP
eurjchem-2103	100	41	bsa	bsa	NOUN
eurjchem-2103	100	42	,	,	PUNCT
eurjchem-2103	100	43	e.g.	e.g.	ADV
eurjchem-2103	100	44	the	the	DET
eurjchem-2103	100	45	carboxyl	carboxyl	NOUN
eurjchem-2103	100	46	group	group	NOUN
eurjchem-2103	100	47	of	of	ADP
eurjchem-2103	100	48	enr	enr	PROPN
eurjchem-2103	100	49	is	be	AUX
eurjchem-2103	100	50	not	not	PART
eurjchem-2103	100	51	fully	fully	ADV
eurjchem-2103	100	52	buried	bury	VERB
eurjchem-2103	100	53	in	in	ADP
eurjchem-2103	100	54	the	the	DET
eurjchem-2103	100	55	protein	protein	NOUN
eurjchem-2103	100	56	binding	bind	VERB
eurjchem-2103	100	57	pocket	pocket	NOUN
eurjchem-2103	100	58	,	,	PUNCT
eurjchem-2103	100	59	and	and	CCONJ
eurjchem-2103	100	60	the	the	DET
eurjchem-2103	100	61	ligands	ligand	NOUN
eurjchem-2103	100	62	chaves	chave	NOUN
eurjchem-2103	100	63	and	and	CCONJ
eurjchem-2103	100	64	vazquez	vazquez	PROPN
eurjchem-2103	100	65	/	/	SYM
eurjchem-2103	100	66	european	european	PROPN
eurjchem-2103	100	67	journal	journal	PROPN
eurjchem-2103	100	68	of	of	ADP
eurjchem-2103	100	69	chemistry	chemistry	NOUN
eurjchem-2103	100	70	12	12	NUM
eurjchem-2103	100	71	(	(	PUNCT
eurjchem-2103	100	72	2	2	NUM
eurjchem-2103	100	73	)	)	PUNCT
eurjchem-2103	100	74	(	(	PUNCT
eurjchem-2103	100	75	2021	2021	NUM
eurjchem-2103	100	76	)	)	PUNCT
eurjchem-2103	100	77	192	192	NUM
eurjchem-2103	100	78	-	-	SYM
eurjchem-2103	100	79	196	196	NUM
eurjchem-2103	100	80	195	195	NUM
eurjchem-2103	100	81	2021	2021	NUM
eurjchem-2103	100	82	–	–	PUNCT
eurjchem-2103	100	83	european	european	ADJ
eurjchem-2103	100	84	journal	journal	NOUN
eurjchem-2103	100	85	of	of	ADP
eurjchem-2103	100	86	chemistry	chemistry	NOUN
eurjchem-2103	100	87	–	–	PUNCT
eurjchem-2103	100	88	cc	cc	NOUN
eurjchem-2103	100	89	by	by	ADP
eurjchem-2103	100	90	nc	nc	PROPN
eurjchem-2103	100	91	–	–	PUNCT
eurjchem-2103	100	92	doi	doi	NOUN
eurjchem-2103	100	93	:	:	PUNCT
eurjchem-2103	100	94	10.5155	10.5155	NUM
eurjchem-2103	100	95	/	/	SYM
eurjchem-2103	100	96	eurjchem.12.2.192	eurjchem.12.2.192	NOUN
eurjchem-2103	100	97	-	-	PUNCT
eurjchem-2103	100	98	196.2103	196.2103	NUM
eurjchem-2103	100	99	table	table	NOUN
eurjchem-2103	100	100	2	2	NUM
eurjchem-2103	100	101	.	.	PUNCT
eurjchem-2103	100	102	amino	amino	NOUN
eurjchem-2103	100	103	acid	acid	NOUN
eurjchem-2103	100	104	residues	residue	NOUN
eurjchem-2103	100	105	involved	involve	VERB
eurjchem-2103	100	106	in	in	ADP
eurjchem-2103	100	107	the	the	DET
eurjchem-2103	100	108	interaction	interaction	NOUN
eurjchem-2103	100	109	bsa	bsa	NOUN
eurjchem-2103	100	110	:	:	PUNCT
eurjchem-2103	100	111	cip	cip	PROPN
eurjchem-2103	100	112	,	,	PUNCT
eurjchem-2103	100	113	bsa	bsa	PROPN
eurjchem-2103	100	114	:	:	PUNCT
eurjchem-2103	100	115	enr	enr	PROPN
eurjchem-2103	100	116	,	,	PUNCT
eurjchem-2103	100	117	and	and	CCONJ
eurjchem-2103	100	118	bsa	bsa	PROPN
eurjchem-2103	100	119	:	:	PUNCT
eurjchem-2103	100	120	pef	pef	NOUN
eurjchem-2103	100	121	in	in	ADP
eurjchem-2103	100	122	the	the	DET
eurjchem-2103	100	123	trp-212	trp-212	NOUN
eurjchem-2103	100	124	-	-	PUNCT
eurjchem-2103	100	125	containing	contain	VERB
eurjchem-2103	100	126	binding	bind	VERB
eurjchem-2103	100	127	site	site	NOUN
eurjchem-2103	100	128	(	(	PUNCT
eurjchem-2103	100	129	chemplp	chemplp	NOUN
eurjchem-2103	100	130	function	function	NOUN
eurjchem-2103	100	131	)	)	PUNCT
eurjchem-2103	100	132	.	.	PUNCT
eurjchem-2103	101	1	sample	sample	NOUN
eurjchem-2103	101	2	amino	amino	NOUN
eurjchem-2103	101	3	acid	acid	NOUN
eurjchem-2103	101	4	residue	residue	NOUN
eurjchem-2103	101	5	interaction	interaction	NOUN
eurjchem-2103	101	6	distance	distance	NOUN
eurjchem-2103	101	7	(	(	PUNCT
eurjchem-2103	101	8	å	å	NOUN
eurjchem-2103	101	9	)	)	PUNCT
eurjchem-2103	101	10	bsa	bsa	NOUN
eurjchem-2103	101	11	:	:	PUNCT
eurjchem-2103	101	12	cip	cip	PROPN
eurjchem-2103	101	13	arg-194	arg-194	PROPN
eurjchem-2103	101	14	hydrogen	hydrogen	NOUN
eurjchem-2103	101	15	bonding	bonding	NOUN
eurjchem-2103	101	16	3.30	3.30	NUM
eurjchem-2103	101	17	leu-197	leu-197	NOUN
eurjchem-2103	101	18	van	van	PROPN
eurjchem-2103	101	19	der	der	NOUN
eurjchem-2103	101	20	waals	waal	NOUN
eurjchem-2103	101	21	2.80	2.80	NUM
eurjchem-2103	101	22	arg-198	arg-198	NOUN
eurjchem-2103	101	23	van	van	PROPN
eurjchem-2103	101	24	der	der	NOUN
eurjchem-2103	101	25	waals	waal	NOUN
eurjchem-2103	101	26	3.50	3.50	NUM
eurjchem-2103	101	27	trp-212	trp-212	PROPN
eurjchem-2103	101	28	van	van	PROPN
eurjchem-2103	101	29	der	der	NOUN
eurjchem-2103	101	30	waals	waal	NOUN
eurjchem-2103	101	31	2.00	2.00	NUM
eurjchem-2103	101	32	arg-217	arg-217	ADJ
eurjchem-2103	101	33	hydrogen	hydrogen	NOUN
eurjchem-2103	101	34	bonding	bonding	NOUN
eurjchem-2103	101	35	3.30	3.30	NUM
eurjchem-2103	101	36	lys-294	lys-294	NOUN
eurjchem-2103	101	37	van	van	PROPN
eurjchem-2103	101	38	der	der	NOUN
eurjchem-2103	101	39	waals	waal	VERB
eurjchem-2103	101	40	2.60	2.60	NUM
eurjchem-2103	101	41	ser-343	ser-343	NOUN
eurjchem-2103	101	42	hydrogen	hydrogen	NOUN
eurjchem-2103	101	43	bonding	bonding	NOUN
eurjchem-2103	101	44	1.70	1.70	NUM
eurjchem-2103	101	45	bsa	bsa	NOUN
eurjchem-2103	101	46	:	:	PUNCT
eurjchem-2103	101	47	enr	enr	PROPN
eurjchem-2103	101	48	arg-194	arg-194	NOUN
eurjchem-2103	101	49	hydrogen	hydrogen	NOUN
eurjchem-2103	101	50	bonding	bonding	NOUN
eurjchem-2103	101	51	3.10	3.10	NUM
eurjchem-2103	101	52	leu-197	leu-197	NOUN
eurjchem-2103	101	53	van	van	PROPN
eurjchem-2103	101	54	der	der	NOUN
eurjchem-2103	101	55	waals	waal	NOUN
eurjchem-2103	101	56	3.40	3.40	NUM
eurjchem-2103	101	57	trp-212	trp-212	PROPN
eurjchem-2103	101	58	van	van	PROPN
eurjchem-2103	101	59	der	der	NOUN
eurjchem-2103	101	60	waals	waal	NOUN
eurjchem-2103	101	61	2.50	2.50	NUM
eurjchem-2103	101	62	arg-217	arg-217	NOUN
eurjchem-2103	101	63	van	van	PROPN
eurjchem-2103	101	64	der	der	PROPN
eurjchem-2103	101	65	waals	waal	NOUN
eurjchem-2103	101	66	2.80	2.80	NUM
eurjchem-2103	101	67	gln-220	gln-220	NOUN
eurjchem-2103	101	68	van	van	PROPN
eurjchem-2103	101	69	der	der	NOUN
eurjchem-2103	101	70	waals	waal	NOUN
eurjchem-2103	101	71	2.60	2.60	NUM
eurjchem-2103	101	72	lys-294	lys-294	NOUN
eurjchem-2103	101	73	van	van	PROPN
eurjchem-2103	101	74	der	der	NOUN
eurjchem-2103	101	75	waals	waal	VERB
eurjchem-2103	101	76	3.60	3.60	NUM
eurjchem-2103	101	77	val-342	val-342	NOUN
eurjchem-2103	101	78	van	van	PROPN
eurjchem-2103	101	79	der	der	NOUN
eurjchem-2103	101	80	waals	waal	NOUN
eurjchem-2103	101	81	1.90	1.90	NUM
eurjchem-2103	101	82	bsa	bsa	NOUN
eurjchem-2103	101	83	:	:	PUNCT
eurjchem-2103	101	84	pef	pef	PROPN
eurjchem-2103	101	85	arg-194	arg-194	PROPN
eurjchem-2103	101	86	van	van	PROPN
eurjchem-2103	101	87	der	der	NOUN
eurjchem-2103	101	88	waals	waal	NOUN
eurjchem-2103	101	89	3.40	3.40	NUM
eurjchem-2103	101	90	leu-197	leu-197	NOUN
eurjchem-2103	101	91	van	van	PROPN
eurjchem-2103	101	92	der	der	NOUN
eurjchem-2103	101	93	waals	waal	NOUN
eurjchem-2103	101	94	2.50	2.50	NUM
eurjchem-2103	101	95	arg-198	arg-198	NOUN
eurjchem-2103	101	96	hydrogen	hydrogen	NOUN
eurjchem-2103	101	97	bonding	bonding	NOUN
eurjchem-2103	101	98	3.80	3.80	NUM
eurjchem-2103	101	99	trp-212	trp-212	NOUN
eurjchem-2103	101	100	hydrogen	hydrogen	NOUN
eurjchem-2103	101	101	bonding	bonding	NOUN
eurjchem-2103	101	102	3.20	3.20	NUM
eurjchem-2103	101	103	arg-217	arg-217	NOUN
eurjchem-2103	101	104	van	van	PROPN
eurjchem-2103	101	105	der	der	NOUN
eurjchem-2103	101	106	waals	waal	NOUN
eurjchem-2103	101	107	2.30	2.30	NUM
eurjchem-2103	101	108	ala-341	ala-341	NOUN
eurjchem-2103	101	109	van	van	PROPN
eurjchem-2103	101	110	der	der	NOUN
eurjchem-2103	101	111	waals	waal	VERB
eurjchem-2103	101	112	3.70	3.70	NUM
eurjchem-2103	101	113	val-342	val-342	NOUN
eurjchem-2103	101	114	van	van	PROPN
eurjchem-2103	101	115	der	der	NOUN
eurjchem-2103	101	116	waals	waal	NOUN
eurjchem-2103	101	117	1.20	1.20	NUM
eurjchem-2103	101	118	ser-343	ser-343	NOUN
eurjchem-2103	101	119	hydrogen	hydrogen	NOUN
eurjchem-2103	101	120	bonding	bonding	NOUN
eurjchem-2103	101	121	2.90	2.90	NUM
eurjchem-2103	101	122	figure	figure	NOUN
eurjchem-2103	101	123	3	3	NUM
eurjchem-2103	101	124	.	.	PUNCT
eurjchem-2103	101	125	best	good	ADJ
eurjchem-2103	101	126	docking	docking	NOUN
eurjchem-2103	101	127	pose	pose	VERB
eurjchem-2103	101	128	for	for	ADP
eurjchem-2103	101	129	the	the	DET
eurjchem-2103	101	130	interaction	interaction	NOUN
eurjchem-2103	101	131	between	between	ADP
eurjchem-2103	101	132	bsa	bsa	PROPN
eurjchem-2103	101	133	and	and	CCONJ
eurjchem-2103	101	134	the	the	DET
eurjchem-2103	101	135	three	three	NUM
eurjchem-2103	101	136	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	101	137	in	in	ADP
eurjchem-2103	101	138	the	the	DET
eurjchem-2103	101	139	trp-212	trp-212	NOUN
eurjchem-2103	101	140	-	-	PUNCT
eurjchem-2103	101	141	containing	contain	VERB
eurjchem-2103	101	142	binding	bind	VERB
eurjchem-2103	101	143	site	site	NOUN
eurjchem-2103	101	144	.	.	PUNCT
eurjchem-2103	102	1	for	for	ADP
eurjchem-2103	102	2	each	each	DET
eurjchem-2103	102	3	case	case	NOUN
eurjchem-2103	102	4	was	be	AUX
eurjchem-2103	102	5	showed	show	VERB
eurjchem-2103	102	6	the	the	DET
eurjchem-2103	102	7	zoom	zoom	NOUN
eurjchem-2103	102	8	representation	representation	NOUN
eurjchem-2103	102	9	corresponding	correspond	VERB
eurjchem-2103	102	10	to	to	ADP
eurjchem-2103	102	11	the	the	DET
eurjchem-2103	102	12	interaction	interaction	NOUN
eurjchem-2103	102	13	bsa	bsa	PROPN
eurjchem-2103	102	14	:	:	PUNCT
eurjchem-2103	102	15	cip	cip	PROPN
eurjchem-2103	102	16	,	,	PUNCT
eurjchem-2103	102	17	bsa	bsa	PROPN
eurjchem-2103	102	18	:	:	PUNCT
eurjchem-2103	102	19	enr	enr	PROPN
eurjchem-2103	102	20	,	,	PUNCT
eurjchem-2103	102	21	and	and	CCONJ
eurjchem-2103	102	22	bsa	bsa	PROPN
eurjchem-2103	102	23	:	:	PUNCT
eurjchem-2103	102	24	pef	pef	PROPN
eurjchem-2103	102	25	.	.	PUNCT
eurjchem-2103	103	1	domains	domain	NOUN
eurjchem-2103	103	2	i	i	PRON
eurjchem-2103	103	3	,	,	PUNCT
eurjchem-2103	103	4	ii	ii	PROPN
eurjchem-2103	103	5	,	,	PUNCT
eurjchem-2103	103	6	and	and	CCONJ
eurjchem-2103	103	7	iii	iii	NOUN
eurjchem-2103	103	8	are	be	AUX
eurjchem-2103	103	9	represented	represent	VERB
eurjchem-2103	103	10	as	as	ADP
eurjchem-2103	103	11	cartoon	cartoon	NOUN
eurjchem-2103	103	12	in	in	ADP
eurjchem-2103	103	13	yellow	yellow	ADJ
eurjchem-2103	103	14	,	,	PUNCT
eurjchem-2103	103	15	beige	beige	ADJ
eurjchem-2103	103	16	and	and	CCONJ
eurjchem-2103	103	17	orange	orange	ADJ
eurjchem-2103	103	18	,	,	PUNCT
eurjchem-2103	103	19	respectively	respectively	ADV
eurjchem-2103	103	20	,	,	PUNCT
eurjchem-2103	103	21	while	while	SCONJ
eurjchem-2103	103	22	the	the	DET
eurjchem-2103	103	23	selected	select	VERB
eurjchem-2103	103	24	amino	amino	NOUN
eurjchem-2103	103	25	acid	acid	NOUN
eurjchem-2103	103	26	residues	residue	NOUN
eurjchem-2103	103	27	,	,	PUNCT
eurjchem-2103	103	28	cip	cip	NOUN
eurjchem-2103	103	29	,	,	PUNCT
eurjchem-2103	103	30	enr	enr	PROPN
eurjchem-2103	103	31	and	and	CCONJ
eurjchem-2103	103	32	pef	pef	NOUN
eurjchem-2103	103	33	are	be	AUX
eurjchem-2103	103	34	represented	represent	VERB
eurjchem-2103	103	35	as	as	ADP
eurjchem-2103	103	36	sticks	stick	NOUN
eurjchem-2103	103	37	in	in	ADP
eurjchem-2103	103	38	green	green	ADJ
eurjchem-2103	103	39	,	,	PUNCT
eurjchem-2103	103	40	brown	brown	ADJ
eurjchem-2103	103	41	,	,	PUNCT
eurjchem-2103	103	42	magenta	magenta	NOUN
eurjchem-2103	103	43	and	and	CCONJ
eurjchem-2103	103	44	purple	purple	ADJ
eurjchem-2103	103	45	,	,	PUNCT
eurjchem-2103	103	46	respectively	respectively	ADV
eurjchem-2103	103	47	.	.	PUNCT
eurjchem-2103	104	1	hydrogen	hydrogen	NOUN
eurjchem-2103	104	2	:	:	PUNCT
eurjchem-2103	104	3	white	white	ADJ
eurjchem-2103	104	4	;	;	PUNCT
eurjchem-2103	104	5	oxygen	oxygen	NOUN
eurjchem-2103	104	6	:	:	PUNCT
eurjchem-2103	104	7	red	red	ADJ
eurjchem-2103	104	8	;	;	PUNCT
eurjchem-2103	104	9	fluorine	fluorine	NOUN
eurjchem-2103	104	10	:	:	PUNCT
eurjchem-2103	104	11	light	light	ADJ
eurjchem-2103	104	12	blue	blue	NOUN
eurjchem-2103	104	13	and	and	CCONJ
eurjchem-2103	104	14	nitrogen	nitrogen	NOUN
eurjchem-2103	104	15	:	:	PUNCT
eurjchem-2103	104	16	dark	dark	ADJ
eurjchem-2103	104	17	blue	blue	NOUN
eurjchem-2103	104	18	.	.	PUNCT
eurjchem-2103	105	1	cip	cip	PROPN
eurjchem-2103	105	2	and	and	CCONJ
eurjchem-2103	105	3	pef	pef	PROPN
eurjchem-2103	105	4	presented	present	VERB
eurjchem-2103	105	5	qualitatively	qualitatively	ADV
eurjchem-2103	105	6	interaction	interaction	NOUN
eurjchem-2103	105	7	similarity	similarity	NOUN
eurjchem-2103	105	8	higher	high	ADJ
eurjchem-2103	105	9	than	than	ADP
eurjchem-2103	105	10	70	70	NUM
eurjchem-2103	105	11	%	%	NOUN
eurjchem-2103	105	12	.	.	PUNCT
eurjchem-2103	106	1	additionally	additionally	ADV
eurjchem-2103	106	2	,	,	PUNCT
eurjchem-2103	106	3	since	since	SCONJ
eurjchem-2103	106	4	bovine	bovine	NOUN
eurjchem-2103	106	5	serum	serum	NOUN
eurjchem-2103	106	6	albumin	albumin	PROPN
eurjchem-2103	106	7	(	(	PUNCT
eurjchem-2103	106	8	bsa	bsa	PROPN
eurjchem-2103	106	9	)	)	PUNCT
eurjchem-2103	106	10	and	and	CCONJ
eurjchem-2103	106	11	human	human	ADJ
eurjchem-2103	106	12	serum	serum	NOUN
eurjchem-2103	106	13	albumin	albumin	PROPN
eurjchem-2103	106	14	(	(	PUNCT
eurjchem-2103	106	15	hsa	hsa	PROPN
eurjchem-2103	106	16	)	)	PUNCT
eurjchem-2103	106	17	share	share	NOUN
eurjchem-2103	106	18	76	76	NUM
eurjchem-2103	106	19	%	%	NOUN
eurjchem-2103	106	20	identity	identity	NOUN
eurjchem-2103	106	21	and	and	CCONJ
eurjchem-2103	106	22	88	88	NUM
eurjchem-2103	106	23	%	%	NOUN
eurjchem-2103	106	24	similarity	similarity	NOUN
eurjchem-2103	106	25	[	[	X
eurjchem-2103	106	26	35,45,46	35,45,46	NUM
eurjchem-2103	106	27	]	]	PUNCT
eurjchem-2103	106	28	,	,	PUNCT
eurjchem-2103	106	29	the	the	DET
eurjchem-2103	106	30	results	result	NOUN
eurjchem-2103	106	31	obtained	obtain	VERB
eurjchem-2103	106	32	for	for	ADP
eurjchem-2103	106	33	bsa	bsa	NOUN
eurjchem-2103	106	34	might	might	AUX
eurjchem-2103	106	35	be	be	AUX
eurjchem-2103	106	36	correlated	correlate	VERB
eurjchem-2103	106	37	with	with	ADP
eurjchem-2103	106	38	hsa	hsa	NOUN
eurjchem-2103	106	39	binding	binding	ADJ
eurjchem-2103	106	40	capacity	capacity	NOUN
eurjchem-2103	106	41	.	.	PUNCT
eurjchem-2103	107	1	4	4	X
eurjchem-2103	107	2	.	.	X
eurjchem-2103	107	3	conclusions	conclusion	NOUN
eurjchem-2103	107	4	the	the	DET
eurjchem-2103	107	5	molecular	molecular	ADJ
eurjchem-2103	107	6	docking	docking	NOUN
eurjchem-2103	107	7	scores	score	NOUN
eurjchem-2103	107	8	suggested	suggest	VERB
eurjchem-2103	107	9	the	the	DET
eurjchem-2103	107	10	trp-212containing	trp-212containe	VERB
eurjchem-2103	107	11	binding	bind	VERB
eurjchem-2103	107	12	site	site	NOUN
eurjchem-2103	107	13	(	(	PUNCT
eurjchem-2103	107	14	site	site	NOUN
eurjchem-2103	107	15	i	i	PRON
eurjchem-2103	107	16	domain	domain	PROPN
eurjchem-2103	107	17	ii	ii	PROPN
eurjchem-2103	107	18	)	)	PUNCT
eurjchem-2103	107	19	as	as	ADP
eurjchem-2103	107	20	the	the	DET
eurjchem-2103	107	21	main	main	ADJ
eurjchem-2103	107	22	binding	bind	VERB
eurjchem-2103	107	23	pocket	pocket	NOUN
eurjchem-2103	107	24	for	for	ADP
eurjchem-2103	107	25	the	the	DET
eurjchem-2103	107	26	three	three	NUM
eurjchem-2103	107	27	commercial	commercial	ADJ
eurjchem-2103	107	28	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	107	29	(	(	PUNCT
eurjchem-2103	107	30	cip	cip	NOUN
eurjchem-2103	107	31	,	,	PUNCT
eurjchem-2103	107	32	enr	enr	PROPN
eurjchem-2103	107	33	,	,	PUNCT
eurjchem-2103	107	34	and	and	CCONJ
eurjchem-2103	107	35	pef	pef	NOUN
eurjchem-2103	107	36	)	)	PUNCT
eurjchem-2103	107	37	.	.	PUNCT
eurjchem-2103	108	1	student	student	NOUN
eurjchem-2103	108	2	's	's	PART
eurjchem-2103	108	3	t	t	PROPN
eurjchem-2103	108	4	-	-	PUNCT
eurjchem-2103	108	5	test	test	NOUN
eurjchem-2103	108	6	indicated	indicate	VERB
eurjchem-2103	108	7	a	a	DET
eurjchem-2103	108	8	statistically	statistically	ADV
eurjchem-2103	108	9	significant	significant	ADJ
eurjchem-2103	108	10	difference	difference	NOUN
eurjchem-2103	108	11	between	between	ADP
eurjchem-2103	108	12	the	the	DET
eurjchem-2103	108	13	two	two	NUM
eurjchem-2103	108	14	main	main	ADJ
eurjchem-2103	108	15	protein	protein	NOUN
eurjchem-2103	108	16	binding	bind	VERB
eurjchem-2103	108	17	sites	site	NOUN
eurjchem-2103	108	18	(	(	PUNCT
eurjchem-2103	108	19	trp134and	trp134and	CCONJ
eurjchem-2103	108	20	trp-212	trp-212	NOUN
eurjchem-2103	108	21	-	-	PUNCT
eurjchem-2103	108	22	containing	contain	VERB
eurjchem-2103	108	23	binding	bind	VERB
eurjchem-2103	108	24	sites	site	NOUN
eurjchem-2103	108	25	)	)	PUNCT
eurjchem-2103	108	26	.	.	PUNCT
eurjchem-2103	109	1	the	the	DET
eurjchem-2103	109	2	hydrogen	hydrogen	NOUN
eurjchem-2103	109	3	bonding	bonding	NOUN
eurjchem-2103	109	4	in	in	ADP
eurjchem-2103	109	5	a	a	DET
eurjchem-2103	109	6	minor	minor	ADJ
eurjchem-2103	109	7	way	way	NOUN
eurjchem-2103	109	8	and	and	CCONJ
eurjchem-2103	109	9	van	van	PROPN
eurjchem-2103	109	10	der	der	NOUN
eurjchem-2103	109	11	waals	waal	NOUN
eurjchem-2103	109	12	forces	force	NOUN
eurjchem-2103	109	13	in	in	ADP
eurjchem-2103	109	14	a	a	DET
eurjchem-2103	109	15	major	major	ADJ
eurjchem-2103	109	16	way	way	NOUN
eurjchem-2103	109	17	are	be	AUX
eurjchem-2103	109	18	the	the	DET
eurjchem-2103	109	19	main	main	ADJ
eurjchem-2103	109	20	chemical	chemical	NOUN
eurjchem-2103	109	21	interactions	interaction	NOUN
eurjchem-2103	109	22	involved	involve	VERB
eurjchem-2103	109	23	between	between	ADP
eurjchem-2103	109	24	bsa	bsa	NOUN
eurjchem-2103	109	25	and	and	CCONJ
eurjchem-2103	109	26	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	109	27	.	.	PUNCT
eurjchem-2103	110	1	overall	overall	ADV
eurjchem-2103	110	2	,	,	PUNCT
eurjchem-2103	110	3	all	all	DET
eurjchem-2103	110	4	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	110	5	presented	present	VERB
eurjchem-2103	110	6	in	in	ADP
eurjchem-2103	110	7	this	this	DET
eurjchem-2103	110	8	study	study	NOUN
eurjchem-2103	110	9	had	have	VERB
eurjchem-2103	110	10	a	a	DET
eurjchem-2103	110	11	significant	significant	ADJ
eurjchem-2103	110	12	theoretical	theoretical	ADJ
eurjchem-2103	110	13	binding	bind	VERB
eurjchem-2103	110	14	capacity	capacity	NOUN
eurjchem-2103	110	15	in	in	ADP
eurjchem-2103	110	16	the	the	DET
eurjchem-2103	110	17	trp-212	trp-212	NOUN
eurjchem-2103	110	18	-	-	PUNCT
eurjchem-2103	110	19	containing	contain	VERB
eurjchem-2103	110	20	binding	bind	VERB
eurjchem-2103	110	21	site	site	NOUN
eurjchem-2103	110	22	,	,	PUNCT
eurjchem-2103	110	23	attributed	attribute	VERB
eurjchem-2103	110	24	mainly	mainly	ADV
eurjchem-2103	110	25	by	by	ADP
eurjchem-2103	110	26	the	the	DET
eurjchem-2103	110	27	slight	slight	ADJ
eurjchem-2103	110	28	structural	structural	ADJ
eurjchem-2103	110	29	differences	difference	NOUN
eurjchem-2103	110	30	among	among	ADP
eurjchem-2103	110	31	the	the	DET
eurjchem-2103	110	32	three	three	NUM
eurjchem-2103	110	33	ligands	ligand	NOUN
eurjchem-2103	110	34	.	.	PUNCT
eurjchem-2103	111	1	there	there	PRON
eurjchem-2103	111	2	were	be	VERB
eurjchem-2103	111	3	196	196	NUM
eurjchem-2103	111	4	chaves	chave	NOUN
eurjchem-2103	111	5	and	and	CCONJ
eurjchem-2103	111	6	vazquez	vazquez	PROPN
eurjchem-2103	111	7	/	/	SYM
eurjchem-2103	111	8	european	european	PROPN
eurjchem-2103	111	9	journal	journal	PROPN
eurjchem-2103	111	10	of	of	ADP
eurjchem-2103	111	11	chemistry	chemistry	NOUN
eurjchem-2103	111	12	12	12	NUM
eurjchem-2103	111	13	(	(	PUNCT
eurjchem-2103	111	14	2	2	NUM
eurjchem-2103	111	15	)	)	PUNCT
eurjchem-2103	111	16	(	(	PUNCT
eurjchem-2103	111	17	2021	2021	NUM
eurjchem-2103	111	18	)	)	PUNCT
eurjchem-2103	111	19	192	192	NUM
eurjchem-2103	111	20	-	-	SYM
eurjchem-2103	111	21	196	196	NUM
eurjchem-2103	111	22	2021	2021	NUM
eurjchem-2103	111	23	–	–	PUNCT
eurjchem-2103	111	24	european	european	ADJ
eurjchem-2103	111	25	journal	journal	NOUN
eurjchem-2103	111	26	of	of	ADP
eurjchem-2103	111	27	chemistry	chemistry	NOUN
eurjchem-2103	111	28	–	–	PUNCT
eurjchem-2103	111	29	cc	cc	NOUN
eurjchem-2103	111	30	by	by	ADP
eurjchem-2103	111	31	nc	nc	PROPN
eurjchem-2103	111	32	–	–	PUNCT
eurjchem-2103	111	33	doi	doi	NOUN
eurjchem-2103	111	34	:	:	PUNCT
eurjchem-2103	111	35	10.5155	10.5155	NUM
eurjchem-2103	111	36	/	/	SYM
eurjchem-2103	111	37	eurjchem.12.2.192	eurjchem.12.2.192	NOUN
eurjchem-2103	111	38	-	-	SYM
eurjchem-2103	111	39	196.2103	196.2103	NUM
eurjchem-2103	111	40	some	some	DET
eurjchem-2103	111	41	particular	particular	ADJ
eurjchem-2103	111	42	features	feature	NOUN
eurjchem-2103	111	43	on	on	ADP
eurjchem-2103	111	44	the	the	DET
eurjchem-2103	111	45	interaction	interaction	NOUN
eurjchem-2103	111	46	toward	toward	ADP
eurjchem-2103	111	47	bsa	bsa	NOUN
eurjchem-2103	111	48	,	,	PUNCT
eurjchem-2103	111	49	e.g.	e.g.	ADV
eurjchem-2103	111	50	the	the	DET
eurjchem-2103	111	51	carboxyl	carboxyl	NOUN
eurjchem-2103	111	52	group	group	NOUN
eurjchem-2103	111	53	of	of	ADP
eurjchem-2103	111	54	enr	enr	PROPN
eurjchem-2103	111	55	is	be	AUX
eurjchem-2103	111	56	not	not	PART
eurjchem-2103	111	57	entirely	entirely	ADV
eurjchem-2103	111	58	buried	bury	VERB
eurjchem-2103	111	59	in	in	ADP
eurjchem-2103	111	60	the	the	DET
eurjchem-2103	111	61	protein	protein	NOUN
eurjchem-2103	111	62	binding	bind	VERB
eurjchem-2103	111	63	pocket	pocket	NOUN
eurjchem-2103	111	64	,	,	PUNCT
eurjchem-2103	111	65	as	as	ADV
eurjchem-2103	111	66	well	well	ADV
eurjchem-2103	111	67	as	as	SCONJ
eurjchem-2103	111	68	this	this	DET
eurjchem-2103	111	69	ligand	ligand	NOUN
eurjchem-2103	111	70	showed	show	VERB
eurjchem-2103	111	71	lower	low	ADJ
eurjchem-2103	111	72	binding	bind	VERB
eurjchem-2103	111	73	capacity	capacity	NOUN
eurjchem-2103	111	74	compared	compare	VERB
eurjchem-2103	111	75	to	to	ADP
eurjchem-2103	111	76	cip	cip	PROPN
eurjchem-2103	111	77	and	and	CCONJ
eurjchem-2103	111	78	pef	pef	NOUN
eurjchem-2103	111	79	,	,	PUNCT
eurjchem-2103	111	80	suggesting	suggest	VERB
eurjchem-2103	111	81	the	the	DET
eurjchem-2103	111	82	behaviour	behaviour	NOUN
eurjchem-2103	111	83	of	of	ADP
eurjchem-2103	111	84	higher	high	ADJ
eurjchem-2103	111	85	partition	partition	NOUN
eurjchem-2103	111	86	of	of	ADP
eurjchem-2103	111	87	enr	enr	NOUN
eurjchem-2103	111	88	to	to	ADP
eurjchem-2103	111	89	the	the	DET
eurjchem-2103	111	90	animal	animal	NOUN
eurjchem-2103	111	91	bloodstream	bloodstream	NOUN
eurjchem-2103	111	92	compared	compare	VERB
eurjchem-2103	111	93	to	to	ADP
eurjchem-2103	111	94	other	other	ADJ
eurjchem-2103	111	95	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2103	111	96	.	.	PUNCT
eurjchem-2103	112	1	acknowledgements	acknowledgement	NOUN
eurjchem-2103	112	2	the	the	DET
eurjchem-2103	112	3	authors	author	NOUN
eurjchem-2103	112	4	gratefully	gratefully	ADV
eurjchem-2103	112	5	acknowledge	acknowledge	VERB
eurjchem-2103	112	6	professor	professor	PROPN
eurjchem-2103	112	7	carlos	carlos	PROPN
eurjchem-2103	112	8	mauricio	mauricio	PROPN
eurjchem-2103	112	9	rabello	rabello	PROPN
eurjchem-2103	112	10	de	de	X
eurjchem-2103	112	11	sant’anna	sant’anna	NOUN
eurjchem-2103	112	12	(	(	PUNCT
eurjchem-2103	112	13	institute	institute	NOUN
eurjchem-2103	112	14	of	of	ADP
eurjchem-2103	112	15	chemistry	chemistry	NOUN
eurjchem-2103	112	16	at	at	ADP
eurjchem-2103	112	17	universidade	universidade	PROPN
eurjchem-2103	112	18	federal	federal	PROPN
eurjchem-2103	112	19	rural	rural	PROPN
eurjchem-2103	112	20	do	do	AUX
eurjchem-2103	112	21	rio	rio	PROPN
eurjchem-2103	112	22	de	de	PROPN
eurjchem-2103	112	23	janeiro	janeiro	PROPN
eurjchem-2103	112	24	)	)	PUNCT
eurjchem-2103	112	25	for	for	ADP
eurjchem-2103	112	26	the	the	DET
eurjchem-2103	112	27	molecular	molecular	ADJ
eurjchem-2103	112	28	docking	docking	NOUN
eurjchem-2103	112	29	facilities	facility	NOUN
eurjchem-2103	112	30	and	and	CCONJ
eurjchem-2103	112	31	the	the	DET
eurjchem-2103	112	32	brazilian	brazilian	ADJ
eurjchem-2103	112	33	agency	agency	NOUN
eurjchem-2103	112	34	coordenação	coordenação	PROPN
eurjchem-2103	112	35	de	de	PROPN
eurjchem-2103	112	36	aperfeiçoamento	aperfeiçoamento	PROPN
eurjchem-2103	112	37	de	de	X
eurjchem-2103	112	38	pessoal	pessoal	PROPN
eurjchem-2103	112	39	de	de	PROPN
eurjchem-2103	112	40	nível	nível	PROPN
eurjchem-2103	112	41	superior	superior	ADJ
eurjchem-2103	112	42	(	(	PUNCT
eurjchem-2103	112	43	capes	cape	NOUN
eurjchem-2103	112	44	)	)	PUNCT
eurjchem-2103	112	45	for	for	ADP
eurjchem-2103	112	46	financial	financial	ADJ
eurjchem-2103	112	47	support	support	NOUN
eurjchem-2103	112	48	.	.	PUNCT
eurjchem-2103	113	1	otávio	otávio	NOUN
eurjchem-2103	113	2	augusto	augusto	PROPN
eurjchem-2103	113	3	chaves	chave	VERB
eurjchem-2103	113	4	also	also	ADV
eurjchem-2103	113	5	thanks	thanks	PROPN
eurjchem-2103	113	6	dr	dr	PROPN
eurjchem-2103	113	7	.	.	PROPN
eurjchem-2103	113	8	thiago	thiago	PROPN
eurjchem-2103	114	1	moreno	moreno	PROPN
eurjchem-2103	114	2	l.	l.	PROPN
eurjchem-2103	114	3	souza	souza	PROPN
eurjchem-2103	114	4	from	from	ADP
eurjchem-2103	114	5	oswaldo	oswaldo	PROPN
eurjchem-2103	114	6	cruz	cruz	PROPN
eurjchem-2103	114	7	foundation	foundation	PROPN
eurjchem-2103	114	8	(	(	PUNCT
eurjchem-2103	114	9	fiocruz	fiocruz	PROPN
eurjchem-2103	114	10	,	,	PUNCT
eurjchem-2103	114	11	rio	rio	PROPN
eurjchem-2103	114	12	de	de	PROPN
eurjchem-2103	114	13	janeiro	janeiro	PROPN
eurjchem-2103	114	14	,	,	PUNCT
eurjchem-2103	114	15	brazil	brazil	PROPN
eurjchem-2103	114	16	)	)	PUNCT
eurjchem-2103	114	17	and	and	CCONJ
eurjchem-2103	114	18	fundação	fundação	ADJ
eurjchem-2103	114	19	para	para	NOUN
eurjchem-2103	114	20	o	o	X
eurjchem-2103	114	21	desenvolvimento	desenvolvimento	PROPN
eurjchem-2103	114	22	científico	científico	PROPN
eurjchem-2103	114	23	e	e	NOUN
eurjchem-2103	114	24	tecnológico	tecnológico	VERB
eurjchem-2103	114	25	em	em	PRON
eurjchem-2103	114	26	saúde	saúde	PROPN
eurjchem-2103	114	27	(	(	PUNCT
eurjchem-2103	114	28	fiotec	fiotec	ADJ
eurjchem-2103	114	29	,	,	PUNCT
eurjchem-2103	114	30	rio	rio	PROPN
eurjchem-2103	114	31	de	de	PROPN
eurjchem-2103	114	32	janeiro	janeiro	PROPN
eurjchem-2103	114	33	,	,	PUNCT
eurjchem-2103	114	34	brazil	brazil	PROPN
eurjchem-2103	114	35	)	)	PUNCT
eurjchem-2103	114	36	for	for	ADP
eurjchem-2103	114	37	the	the	DET
eurjchem-2103	114	38	grant	grant	NOUN
eurjchem-2103	114	39	117235	117235	NUM
eurjchem-2103	114	40	in	in	ADP
eurjchem-2103	114	41	the	the	DET
eurjchem-2103	114	42	project	project	NOUN
eurjchem-2103	114	43	vpgdi-032	vpgdi-032	NOUN
eurjchem-2103	114	44	-	-	PUNCT
eurjchem-2103	114	45	arc-20	arc-20	PROPN
eurjchem-2103	114	46	.	.	PROPN
eurjchem-2103	114	47	disclosure	disclosure	NOUN
eurjchem-2103	114	48	statement	statement	NOUN
eurjchem-2103	114	49	conflict	conflict	NOUN
eurjchem-2103	114	50	of	of	ADP
eurjchem-2103	114	51	interests	interest	NOUN
eurjchem-2103	114	52	:	:	PUNCT
eurjchem-2103	114	53	the	the	DET
eurjchem-2103	114	54	authors	author	NOUN
eurjchem-2103	114	55	declare	declare	VERB
eurjchem-2103	114	56	that	that	SCONJ
eurjchem-2103	114	57	they	they	PRON
eurjchem-2103	114	58	have	have	VERB
eurjchem-2103	114	59	no	no	DET
eurjchem-2103	114	60	conflict	conflict	NOUN
eurjchem-2103	114	61	of	of	ADP
eurjchem-2103	114	62	interest	interest	NOUN
eurjchem-2103	114	63	.	.	PUNCT
eurjchem-2103	115	1	author	author	NOUN
eurjchem-2103	115	2	contributions	contribution	NOUN
eurjchem-2103	115	3	:	:	PUNCT
eurjchem-2103	115	4	otávio	otávio	NOUN
eurjchem-2103	115	5	augusto	augusto	PROPN
eurjchem-2103	115	6	chaves	chaves	PROPN
eurjchem-2103	115	7	conducted	conduct	VERB
eurjchem-2103	115	8	the	the	DET
eurjchem-2103	115	9	molecular	molecular	ADJ
eurjchem-2103	115	10	docking	docking	NOUN
eurjchem-2103	115	11	calculations	calculation	NOUN
eurjchem-2103	115	12	.	.	PUNCT
eurjchem-2103	116	1	otávio	otávio	NOUN
eurjchem-2103	116	2	augusto	augusto	PROPN
eurjchem-2103	116	3	chaves	chave	NOUN
eurjchem-2103	116	4	and	and	CCONJ
eurjchem-2103	116	5	leonardo	leonardo	PROPN
eurjchem-2103	116	6	vazquez	vazquez	PROPN
eurjchem-2103	116	7	wrote	write	VERB
eurjchem-2103	116	8	the	the	DET
eurjchem-2103	116	9	manuscript	manuscript	NOUN
eurjchem-2103	116	10	.	.	PUNCT
eurjchem-2103	117	1	ethical	ethical	ADJ
eurjchem-2103	117	2	approval	approval	NOUN
eurjchem-2103	117	3	:	:	PUNCT
eurjchem-2103	118	1	all	all	DET
eurjchem-2103	118	2	ethical	ethical	ADJ
eurjchem-2103	118	3	guidelines	guideline	NOUN
eurjchem-2103	118	4	have	have	AUX
eurjchem-2103	118	5	been	be	AUX
eurjchem-2103	118	6	adhered	adhere	VERB
eurjchem-2103	118	7	.	.	PUNCT
eurjchem-2103	119	1	funding	fund	VERB
eurjchem-2103	119	2	coordenação	coordenação	PROPN
eurjchem-2103	119	3	de	de	PROPN
eurjchem-2103	119	4	aperfeiçoamento	aperfeiçoamento	PROPN
eurjchem-2103	119	5	de	de	X
eurjchem-2103	119	6	pessoal	pessoal	PROPN
eurjchem-2103	119	7	de	de	PROPN
eurjchem-2103	119	8	nível	nível	PROPN
eurjchem-2103	119	9	superior	superior	ADJ
eurjchem-2103	119	10	(	(	PUNCT
eurjchem-2103	119	11	capes	cape	NOUN
eurjchem-2103	119	12	,	,	PUNCT
eurjchem-2103	119	13	brazil	brazil	PROPN
eurjchem-2103	119	14	)	)	PUNCT
eurjchem-2103	119	15	.	.	PUNCT
eurjchem-2103	120	1	orcid	orcid	NOUN
eurjchem-2103	120	2	otávio	otávio	NOUN
eurjchem-2103	120	3	augusto	augusto	PROPN
eurjchem-2103	120	4	chaves	chaves	PROPN
eurjchem-2103	120	5	https://orcid.org/0000-0001-6211-7659	https://orcid.org/0000-0001-6211-7659	PROPN
eurjchem-2103	120	6	leonardo	leonardo	PROPN
eurjchem-2103	120	7	vazquez	vazquez	PROPN
eurjchem-2103	120	8	https://orcid.org/0000-0002-1306-2644	https://orcid.org/0000-0002-1306-2644	PROPN
eurjchem-2103	120	9	references	reference	NOUN
eurjchem-2103	120	10	[	[	X
eurjchem-2103	120	11	1	1	NUM
eurjchem-2103	120	12	]	]	PUNCT
eurjchem-2103	120	13	.	.	PUNCT
eurjchem-2103	121	1	drlica	drlica	PROPN
eurjchem-2103	121	2	,	,	PUNCT
eurjchem-2103	121	3	k.	k.	PROPN
eurjchem-2103	121	4	curr	curr	PROPN
eurjchem-2103	121	5	.	.	PUNCT
eurjchem-2103	122	1	opin	opin	NOUN
eurjchem-2103	122	2	.	.	PUNCT
eurjchem-2103	123	1	microbiol	microbiol	PROPN
eurjchem-2103	123	2	.	.	PUNCT
eurjchem-2103	124	1	1999	1999	NUM
eurjchem-2103	124	2	,	,	PUNCT
eurjchem-2103	124	3	2	2	NUM
eurjchem-2103	124	4	,	,	PUNCT
eurjchem-2103	124	5	504–508	504–508	NUM
eurjchem-2103	124	6	.	.	PUNCT
eurjchem-2103	125	1	[	[	X
eurjchem-2103	125	2	2	2	NUM
eurjchem-2103	125	3	]	]	PUNCT
eurjchem-2103	125	4	.	.	PUNCT
eurjchem-2103	125	5	brown	brown	PROPN
eurjchem-2103	125	6	,	,	PUNCT
eurjchem-2103	125	7	s.	s.	PROPN
eurjchem-2103	125	8	a.	a.	PROPN
eurjchem-2103	125	9	j.	j.	PROPN
eurjchem-2103	125	10	vet	vet	PROPN
eurjchem-2103	125	11	.	.	PUNCT
eurjchem-2103	126	1	pharmacol	pharmacol	PROPN
eurjchem-2103	126	2	.	.	PUNCT
eurjchem-2103	127	1	ther	ther	PROPN
eurjchem-2103	127	2	.	.	PUNCT
eurjchem-2103	128	1	1996	1996	NUM
eurjchem-2103	128	2	,	,	PUNCT
eurjchem-2103	128	3	19	19	NUM
eurjchem-2103	128	4	,	,	PUNCT
eurjchem-2103	128	5	1–14	1–14	PROPN
eurjchem-2103	128	6	.	.	PUNCT
eurjchem-2103	129	1	[	[	X
eurjchem-2103	129	2	3	3	NUM
eurjchem-2103	129	3	]	]	PUNCT
eurjchem-2103	129	4	.	.	PUNCT
eurjchem-2103	130	1	gootz	gootz	PROPN
eurjchem-2103	130	2	,	,	PUNCT
eurjchem-2103	130	3	t.	t.	PROPN
eurjchem-2103	130	4	d.	d.	PROPN
eurjchem-2103	130	5	;	;	PUNCT
eurjchem-2103	130	6	brighty	brighty	VERB
eurjchem-2103	130	7	,	,	PUNCT
eurjchem-2103	130	8	k.	k.	PROPN
eurjchem-2103	130	9	e.	e.	PROPN
eurjchem-2103	130	10	med	med	PROPN
eurjchem-2103	130	11	.	.	PUNCT
eurjchem-2103	131	1	res	re	NOUN
eurjchem-2103	131	2	.	.	PUNCT
eurjchem-2103	132	1	rev	rev	PROPN
eurjchem-2103	132	2	.	.	PROPN
eurjchem-2103	132	3	1996	1996	NUM
eurjchem-2103	132	4	,	,	PUNCT
eurjchem-2103	132	5	16	16	NUM
eurjchem-2103	132	6	,	,	PUNCT
eurjchem-2103	132	7	433–486	433–486	NUM
eurjchem-2103	132	8	.	.	PUNCT
eurjchem-2103	133	1	[	[	X
eurjchem-2103	133	2	4	4	NUM
eurjchem-2103	133	3	]	]	PUNCT
eurjchem-2103	133	4	.	.	PUNCT
eurjchem-2103	134	1	singh	singh	PROPN
eurjchem-2103	134	2	,	,	PUNCT
eurjchem-2103	134	3	s.	s.	PROPN
eurjchem-2103	134	4	;	;	PUNCT
eurjchem-2103	134	5	shukla	shukla	NOUN
eurjchem-2103	134	6	,	,	PUNCT
eurjchem-2103	134	7	s.	s.	PROPN
eurjchem-2103	134	8	;	;	PUNCT
eurjchem-2103	134	9	tandia	tandia	NOUN
eurjchem-2103	134	10	,	,	PUNCT
eurjchem-2103	134	11	n.	n.	NOUN
eurjchem-2103	134	12	;	;	PUNCT
eurjchem-2103	134	13	kumar	kumar	PROPN
eurjchem-2103	134	14	,	,	PUNCT
eurjchem-2103	134	15	n.	n.	NOUN
eurjchem-2103	134	16	;	;	PUNCT
eurjchem-2103	134	17	paliwal	paliwal	NOUN
eurjchem-2103	134	18	,	,	PUNCT
eurjchem-2103	134	19	r.	r.	PROPN
eurjchem-2103	134	20	pharm	pharm	PROPN
eurjchem-2103	134	21	.	.	PUNCT
eurjchem-2103	135	1	sci	sci	PROPN
eurjchem-2103	135	2	.	.	PUNCT
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eurjchem-2103	135	5	,	,	PUNCT
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eurjchem-2103	135	7	,	,	PUNCT
eurjchem-2103	135	8	184	184	NUM
eurjchem-2103	135	9	-	-	SYM
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eurjchem-2103	135	11	.	.	PUNCT
eurjchem-2103	136	1	http://www.pharmasm.com/pdf_files/	http://www.pharmasm.com/pdf_files/	PROPN
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eurjchem-2103	136	3	(	(	PUNCT
eurjchem-2103	136	4	accessed	access	VERB
eurjchem-2103	136	5	april	april	PROPN
eurjchem-2103	136	6	6	6	NUM
eurjchem-2103	136	7	,	,	PUNCT
eurjchem-2103	136	8	2021	2021	NUM
eurjchem-2103	136	9	)	)	PUNCT
eurjchem-2103	136	10	.	.	PUNCT
eurjchem-2103	137	1	[	[	X
eurjchem-2103	137	2	5	5	NUM
eurjchem-2103	137	3	]	]	PUNCT
eurjchem-2103	137	4	.	.	PUNCT
eurjchem-2103	138	1	kumar	kumar	PROPN
eurjchem-2103	138	2	,	,	PUNCT
eurjchem-2103	138	3	b.	b.	PROPN
eurjchem-2103	138	4	s.	s.	PROPN
eurjchem-2103	138	5	;	;	PUNCT
eurjchem-2103	138	6	ashok	ashok	NOUN
eurjchem-2103	138	7	,	,	PUNCT
eurjchem-2103	138	8	v.	v.	PROPN
eurjchem-2103	138	9	;	;	PUNCT
eurjchem-2103	138	10	kalyani	kalyani	PROPN
eurjchem-2103	138	11	,	,	PUNCT
eurjchem-2103	138	12	p.	p.	NOUN
eurjchem-2103	138	13	;	;	PUNCT
eurjchem-2103	138	14	nair	nair	PROPN
eurjchem-2103	138	15	,	,	PUNCT
eurjchem-2103	138	16	g.	g.	PROPN
eurjchem-2103	138	17	r.	r.	PROPN
eurjchem-2103	138	18	vet	vet	PROPN
eurjchem-2103	138	19	.	.	PUNCT
eurjchem-2103	139	1	world	world	PROPN
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eurjchem-2103	139	3	,	,	PUNCT
eurjchem-2103	139	4	9	9	NUM
eurjchem-2103	139	5	,	,	PUNCT
eurjchem-2103	139	6	410	410	NUM
eurjchem-2103	139	7	–	–	PUNCT
eurjchem-2103	139	8	416	416	NUM
eurjchem-2103	139	9	.	.	PUNCT
eurjchem-2103	140	1	[	[	X
eurjchem-2103	140	2	6	6	NUM
eurjchem-2103	140	3	]	]	PUNCT
eurjchem-2103	140	4	.	.	PUNCT
eurjchem-2103	141	1	committee	committee	NOUN
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eurjchem-2103	141	3	veterinary	veterinary	ADJ
eurjchem-2103	141	4	medicinal	medicinal	ADJ
eurjchem-2103	141	5	products	product	NOUN
eurjchem-2103	141	6	.	.	PUNCT
eurjchem-2103	142	1	the	the	DET
eurjchem-2103	142	2	european	european	PROPN
eurjchem-2103	142	3	agency	agency	PROPN
eurjchem-2103	142	4	for	for	ADP
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eurjchem-2103	142	9	products	product	NOUN
eurjchem-2103	142	10	–	–	PUNCT
eurjchem-2103	142	11	veterinary	veterinary	ADJ
eurjchem-2103	142	12	medicines	medicine	NOUN
eurjchem-2103	142	13	evaluation	evaluation	NOUN
eurjchem-2103	142	14	unit	unit	NOUN
eurjchem-2103	142	15	,	,	PUNCT
eurjchem-2103	142	16	https://www.ema.europa.eu/en/committees/	https://www.ema.europa.eu/en/committees/	PROPN
eurjchem-2103	142	17	committee	committee	NOUN
eurjchem-2103	142	18	-	-	PUNCT
eurjchem-2103	142	19	medicinal	medicinal	ADJ
eurjchem-2103	142	20	-	-	PUNCT
eurjchem-2103	142	21	products	product	NOUN
eurjchem-2103	142	22	-	-	PUNCT
eurjchem-2103	142	23	veterinary	veterinary	ADJ
eurjchem-2103	142	24	-	-	PUNCT
eurjchem-2103	142	25	use	use	NOUN
eurjchem-2103	142	26	-	-	PUNCT
eurjchem-2103	142	27	cvmp	cvmp	NOUN
eurjchem-2103	142	28	(	(	PUNCT
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eurjchem-2103	142	30	april	april	PROPN
eurjchem-2103	142	31	6	6	NUM
eurjchem-2103	142	32	,	,	PUNCT
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eurjchem-2103	142	34	)	)	PUNCT
eurjchem-2103	142	35	.	.	PUNCT
eurjchem-2103	143	1	[	[	X
eurjchem-2103	143	2	7	7	NUM
eurjchem-2103	143	3	]	]	PUNCT
eurjchem-2103	143	4	.	.	PUNCT
eurjchem-2103	144	1	anand	anand	PROPN
eurjchem-2103	144	2	,	,	PUNCT
eurjchem-2103	144	3	u.	u.	PROPN
eurjchem-2103	144	4	;	;	PUNCT
eurjchem-2103	144	5	kurup	kurup	NOUN
eurjchem-2103	144	6	,	,	PUNCT
eurjchem-2103	144	7	l.	l.	PROPN
eurjchem-2103	144	8	;	;	PUNCT
eurjchem-2103	144	9	mukherjee	mukherjee	PROPN
eurjchem-2103	144	10	,	,	PUNCT
eurjchem-2103	144	11	s.	s.	PROPN
eurjchem-2103	144	12	phys	phys	PROPN
eurjchem-2103	144	13	.	.	PUNCT
eurjchem-2103	145	1	chem	chem	PROPN
eurjchem-2103	145	2	.	.	PUNCT
eurjchem-2103	146	1	chem	chem	NOUN
eurjchem-2103	146	2	.	.	PUNCT
eurjchem-2103	147	1	phys	phy	NOUN
eurjchem-2103	147	2	.	.	PUNCT
eurjchem-2103	148	1	2012	2012	NUM
eurjchem-2103	148	2	,	,	PUNCT
eurjchem-2103	148	3	14	14	NUM
eurjchem-2103	148	4	,	,	PUNCT
eurjchem-2103	148	5	4250–4258	4250–4258	NUM
eurjchem-2103	148	6	.	.	PUNCT
eurjchem-2103	149	1	[	[	X
eurjchem-2103	149	2	8	8	NUM
eurjchem-2103	149	3	]	]	PUNCT
eurjchem-2103	149	4	.	.	PUNCT
eurjchem-2103	149	5	lizondo	lizondo	PROPN
eurjchem-2103	149	6	,	,	PUNCT
eurjchem-2103	149	7	m.	m.	NOUN
eurjchem-2103	149	8	;	;	PUNCT
eurjchem-2103	149	9	pons	pon	NOUN
eurjchem-2103	149	10	,	,	PUNCT
eurjchem-2103	149	11	m.	m.	NOUN
eurjchem-2103	149	12	;	;	PUNCT
eurjchem-2103	149	13	gallardo	gallardo	PROPN
eurjchem-2103	149	14	,	,	PUNCT
eurjchem-2103	149	15	m.	m.	NOUN
eurjchem-2103	149	16	;	;	PUNCT
eurjchem-2103	149	17	estelrich	estelrich	ADJ
eurjchem-2103	149	18	,	,	PUNCT
eurjchem-2103	149	19	j.	j.	PROPN
eurjchem-2103	149	20	j.	j.	PROPN
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eurjchem-2103	149	22	.	.	PUNCT
eurjchem-2103	149	23	biomed	biome	VERB
eurjchem-2103	149	24	.	.	PUNCT
eurjchem-2103	150	1	anal	anal	ADJ
eurjchem-2103	150	2	.	.	PUNCT
eurjchem-2103	151	1	1997	1997	NUM
eurjchem-2103	151	2	,	,	PUNCT
eurjchem-2103	151	3	15	15	NUM
eurjchem-2103	151	4	,	,	PUNCT
eurjchem-2103	151	5	1845–1849	1845–1849	NUM
eurjchem-2103	151	6	.	.	PUNCT
eurjchem-2103	152	1	[	[	X
eurjchem-2103	152	2	9	9	NUM
eurjchem-2103	152	3	]	]	PUNCT
eurjchem-2103	152	4	.	.	PUNCT
eurjchem-2103	153	1	bryskier	bryski	ADJ
eurjchem-2103	153	2	,	,	PUNCT
eurjchem-2103	153	3	a.	a.	NOUN
eurjchem-2103	153	4	antibiotiques	antibiotique	NOUN
eurjchem-2103	153	5	,	,	PUNCT
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eurjchem-2103	153	7	antibactériens	antibactérien	VERB
eurjchem-2103	153	8	et	et	NOUN
eurjchem-2103	153	9	antifongiques	antifongique	NOUN
eurjchem-2103	153	10	;	;	PUNCT
eurjchem-2103	153	11	1st	1st	ADJ
eurjchem-2103	153	12	ed	ed	NOUN
eurjchem-2103	153	13	.	.	PUNCT
eurjchem-2103	153	14	;	;	PUNCT
eurjchem-2103	153	15	ellipses	ellipsis	NOUN
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eurjchem-2103	153	18	,	,	PUNCT
eurjchem-2103	153	19	1999	1999	NUM
eurjchem-2103	153	20	.	.	PUNCT
eurjchem-2103	154	1	[	[	X
eurjchem-2103	154	2	10	10	NUM
eurjchem-2103	154	3	]	]	PUNCT
eurjchem-2103	154	4	.	.	PUNCT
eurjchem-2103	155	1	sárközy	sárközy	PROPN
eurjchem-2103	155	2	,	,	PUNCT
eurjchem-2103	155	3	g.	g.	PROPN
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eurjchem-2103	155	5	.	.	PUNCT
eurjchem-2103	156	1	med	med	PROPN
eurjchem-2103	156	2	.	.	PUNCT
eurjchem-2103	157	1	(	(	PUNCT
eurjchem-2103	157	2	praha	praha	PROPN
eurjchem-2103	157	3	)	)	PUNCT
eurjchem-2103	157	4	2001	2001	NUM
eurjchem-2103	157	5	,	,	PUNCT
eurjchem-2103	157	6	46	46	NUM
eurjchem-2103	157	7	,	,	PUNCT
eurjchem-2103	157	8	257–274	257–274	NUM
eurjchem-2103	157	9	.	.	PUNCT
eurjchem-2103	158	1	[	[	X
eurjchem-2103	158	2	11	11	NUM
eurjchem-2103	158	3	]	]	PUNCT
eurjchem-2103	158	4	.	.	PUNCT
eurjchem-2103	159	1	lekeux	lekeux	PROPN
eurjchem-2103	159	2	,	,	PUNCT
eurjchem-2103	159	3	p.	p.	NOUN
eurjchem-2103	159	4	;	;	PUNCT
eurjchem-2103	159	5	art	art	NOUN
eurjchem-2103	159	6	,	,	PUNCT
eurjchem-2103	159	7	t.	t.	PROPN
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eurjchem-2103	159	9	.	.	PUNCT
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eurjchem-2103	160	2	.	.	PROPN
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eurjchem-2103	160	4	,	,	PUNCT
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eurjchem-2103	160	6	,	,	PUNCT
eurjchem-2103	160	7	205–207	205–207	NUM
eurjchem-2103	160	8	.	.	PUNCT
eurjchem-2103	161	1	[	[	X
eurjchem-2103	161	2	12	12	NUM
eurjchem-2103	161	3	]	]	PUNCT
eurjchem-2103	161	4	.	.	PUNCT
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eurjchem-2103	162	2	,	,	PUNCT
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eurjchem-2103	162	9	;	;	PUNCT
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eurjchem-2103	162	12	.	.	PUNCT
eurjchem-2103	162	13	;	;	PUNCT
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eurjchem-2103	162	20	.	.	PUNCT
eurjchem-2103	163	1	[	[	X
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eurjchem-2103	163	3	]	]	PUNCT
eurjchem-2103	163	4	.	.	PUNCT
eurjchem-2103	164	1	qin	qin	PROPN
eurjchem-2103	164	2	,	,	PUNCT
eurjchem-2103	164	3	j.	j.	PROPN
eurjchem-2103	164	4	;	;	PUNCT
eurjchem-2103	164	5	sun	sun	PROPN
eurjchem-2103	164	6	,	,	PUNCT
eurjchem-2103	164	7	y.	y.	PROPN
eurjchem-2103	164	8	mod	mod	PROPN
eurjchem-2103	164	9	.	.	PUNCT
eurjchem-2103	164	10	appl	appl	PROPN
eurjchem-2103	164	11	.	.	PUNCT
eurjchem-2103	165	1	sci	sci	PROPN
eurjchem-2103	165	2	.	.	PROPN
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eurjchem-2103	165	4	,	,	PUNCT
eurjchem-2103	165	5	3	3	NUM
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eurjchem-2103	165	8	.	.	PUNCT
eurjchem-2103	166	1	[	[	X
eurjchem-2103	166	2	14	14	NUM
eurjchem-2103	166	3	]	]	PUNCT
eurjchem-2103	166	4	.	.	PUNCT
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eurjchem-2103	167	2	,	,	PUNCT
eurjchem-2103	167	3	f.	f.	PROPN
eurjchem-2103	167	4	;	;	PUNCT
eurjchem-2103	167	5	gonçalves	gonçalves	PROPN
eurjchem-2103	167	6	,	,	PUNCT
eurjchem-2103	167	7	f.	f.	PROPN
eurjchem-2103	167	8	;	;	PUNCT
eurjchem-2103	167	9	gouby	gouby	PROPN
eurjchem-2103	167	10	,	,	PUNCT
eurjchem-2103	167	11	a.	a.	NOUN
eurjchem-2103	167	12	;	;	PUNCT
eurjchem-2103	167	13	galtier	galtier	NOUN
eurjchem-2103	167	14	,	,	PUNCT
eurjchem-2103	167	15	m.	m.	NOUN
eurjchem-2103	167	16	clin	clin	PROPN
eurjchem-2103	167	17	.	.	PUNCT
eurjchem-2103	168	1	pharmacokinet	pharmacokinet	PROPN
eurjchem-2103	168	2	.	.	PUNCT
eurjchem-2103	169	1	1994	1994	NUM
eurjchem-2103	169	2	,	,	PUNCT
eurjchem-2103	169	3	27	27	NUM
eurjchem-2103	169	4	,	,	PUNCT
eurjchem-2103	169	5	418–446	418–446	NUM
eurjchem-2103	169	6	.	.	PUNCT
eurjchem-2103	170	1	[	[	X
eurjchem-2103	170	2	15	15	NUM
eurjchem-2103	170	3	]	]	PUNCT
eurjchem-2103	170	4	.	.	PUNCT
eurjchem-2103	170	5	kronfeld	kronfeld	PROPN
eurjchem-2103	170	6	,	,	PUNCT
eurjchem-2103	170	7	d.	d.	PROPN
eurjchem-2103	170	8	s.	s.	PROPN
eurjchem-2103	170	9	;	;	PUNCT
eurjchem-2103	170	10	donoghue	donoghue	PROPN
eurjchem-2103	170	11	,	,	PUNCT
eurjchem-2103	170	12	s.	s.	PROPN
eurjchem-2103	170	13	;	;	PUNCT
eurjchem-2103	170	14	copp	copp	PROPN
eurjchem-2103	170	15	,	,	PUNCT
eurjchem-2103	170	16	r.	r.	PROPN
eurjchem-2103	170	17	l.	l.	PROPN
eurjchem-2103	170	18	;	;	PUNCT
eurjchem-2103	170	19	stearns	stearns	PROPN
eurjchem-2103	170	20	,	,	PUNCT
eurjchem-2103	170	21	f.	f.	PROPN
eurjchem-2103	170	22	m.	m.	PROPN
eurjchem-2103	170	23	;	;	PUNCT
eurjchem-2103	170	24	engle	engle	PROPN
eurjchem-2103	170	25	,	,	PUNCT
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eurjchem-2103	170	29	dairy	dairy	PROPN
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eurjchem-2103	170	33	,	,	PUNCT
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eurjchem-2103	170	37	.	.	PUNCT
eurjchem-2103	171	1	[	[	X
eurjchem-2103	171	2	16	16	NUM
eurjchem-2103	171	3	]	]	PUNCT
eurjchem-2103	171	4	.	.	PUNCT
eurjchem-2103	172	1	sułkowska	sułkowska	PROPN
eurjchem-2103	172	2	,	,	PUNCT
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eurjchem-2103	172	4	;	;	PUNCT
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eurjchem-2103	172	6	-	-	PUNCT
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eurjchem-2103	172	10	;	;	PUNCT
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eurjchem-2103	172	12	,	,	PUNCT
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eurjchem-2103	172	14	;	;	PUNCT
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eurjchem-2103	172	20	,	,	PUNCT
eurjchem-2103	172	21	i.	i.	PROPN
eurjchem-2103	172	22	;	;	PUNCT
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eurjchem-2103	172	24	,	,	PUNCT
eurjchem-2103	172	25	e.	e.	PROPN
eurjchem-2103	172	26	;	;	PUNCT
eurjchem-2103	172	27	pentak	pentak	PROPN
eurjchem-2103	172	28	,	,	PUNCT
eurjchem-2103	172	29	d.	d.	PROPN
eurjchem-2103	172	30	;	;	PUNCT
eurjchem-2103	172	31	sułkowski	sułkowski	PROPN
eurjchem-2103	172	32	,	,	PUNCT
eurjchem-2103	172	33	w.	w.	PROPN
eurjchem-2103	172	34	w.	w.	PROPN
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eurjchem-2103	172	39	.	.	PUNCT
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eurjchem-2103	172	41	,	,	PUNCT
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eurjchem-2103	172	43	,	,	PUNCT
eurjchem-2103	172	44	97–106	97–106	NUM
eurjchem-2103	172	45	.	.	PUNCT
eurjchem-2103	173	1	[	[	X
eurjchem-2103	173	2	17	17	NUM
eurjchem-2103	173	3	]	]	PUNCT
eurjchem-2103	173	4	.	.	PUNCT
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eurjchem-2103	174	2	,	,	PUNCT
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eurjchem-2103	175	4	.	.	PUNCT
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eurjchem-2103	176	4	;	;	PUNCT
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eurjchem-2103	176	6	,	,	PUNCT
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eurjchem-2103	176	8	;	;	PUNCT
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eurjchem-2103	178	2	.	.	PUNCT
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eurjchem-2103	179	2	,	,	PUNCT
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eurjchem-2103	179	4	,	,	PUNCT
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eurjchem-2103	180	4	.	.	PUNCT
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eurjchem-2103	181	2	,	,	PUNCT
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eurjchem-2103	181	5	;	;	PUNCT
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eurjchem-2103	181	7	,	,	PUNCT
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eurjchem-2103	181	19	,	,	PUNCT
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eurjchem-2103	181	24	-	-	PUNCT
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eurjchem-2103	181	26	,	,	PUNCT
eurjchem-2103	181	27	d.	d.	PROPN
eurjchem-2103	181	28	;	;	PUNCT
eurjchem-2103	181	29	ferreira	ferreira	PROPN
eurjchem-2103	181	30	,	,	PUNCT
eurjchem-2103	181	31	a.	a.	PROPN
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eurjchem-2103	181	35	.	.	PUNCT
eurjchem-2103	182	1	j.	j.	PROPN
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eurjchem-2103	183	2	,	,	PUNCT
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eurjchem-2103	183	4	,	,	PUNCT
eurjchem-2103	183	5	331	331	NUM
eurjchem-2103	183	6	–	–	PUNCT
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eurjchem-2103	183	8	.	.	PUNCT
eurjchem-2103	184	1	[	[	X
eurjchem-2103	184	2	20	20	NUM
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eurjchem-2103	184	4	.	.	PUNCT
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eurjchem-2103	185	2	,	,	PUNCT
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eurjchem-2103	185	5	;	;	PUNCT
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eurjchem-2103	185	12	;	;	PUNCT
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eurjchem-2103	185	37	;	;	PUNCT
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eurjchem-2103	185	41	,	,	PUNCT
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eurjchem-2103	185	44	;	;	PUNCT
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eurjchem-2103	185	46	,	,	PUNCT
eurjchem-2103	185	47	a.	a.	PROPN
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eurjchem-2103	186	4	.	.	PUNCT
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eurjchem-2103	187	5	;	;	PUNCT
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eurjchem-2103	187	23	;	;	PUNCT
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eurjchem-2103	187	39	,	,	PUNCT
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eurjchem-2103	187	50	.	.	PUNCT
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eurjchem-2103	189	4	.	.	PUNCT
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eurjchem-2103	190	5	;	;	PUNCT
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eurjchem-2103	190	27	.	.	PUNCT
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eurjchem-2103	191	3	.	.	PUNCT
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eurjchem-2103	192	2	,	,	PUNCT
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eurjchem-2103	192	4	,	,	PUNCT
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eurjchem-2103	192	6	.	.	PUNCT
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eurjchem-2103	193	4	.	.	PUNCT
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eurjchem-2103	193	8	;	;	PUNCT
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eurjchem-2103	194	2	,	,	PUNCT
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eurjchem-2103	194	4	,	,	PUNCT
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eurjchem-2103	194	6	.	.	PUNCT
eurjchem-2103	195	1	[	[	X
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eurjchem-2103	195	4	.	.	PUNCT
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eurjchem-2103	196	4	;	;	PUNCT
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eurjchem-2103	196	8	;	;	PUNCT
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eurjchem-2103	196	20	;	;	PUNCT
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eurjchem-2103	196	22	,	,	PUNCT
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eurjchem-2103	196	24	;	;	PUNCT
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eurjchem-2103	197	2	,	,	PUNCT
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eurjchem-2103	197	4	,	,	PUNCT
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eurjchem-2103	197	6	.	.	PUNCT
eurjchem-2103	198	1	[	[	X
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eurjchem-2103	198	4	.	.	PUNCT
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eurjchem-2103	199	6	,	,	PUNCT
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eurjchem-2103	199	8	;	;	PUNCT
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eurjchem-2103	199	13	.	.	PUNCT
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eurjchem-2103	201	2	.	.	PUNCT
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eurjchem-2103	202	2	,	,	PUNCT
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eurjchem-2103	202	6	.	.	PUNCT
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eurjchem-2103	203	3	]	]	PUNCT
eurjchem-2103	203	4	.	.	PUNCT
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eurjchem-2103	204	2	,	,	PUNCT
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eurjchem-2103	204	4	;	;	PUNCT
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eurjchem-2103	204	6	,	,	PUNCT
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eurjchem-2103	204	8	.	.	PUNCT
eurjchem-2103	204	9	;	;	PUNCT
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eurjchem-2103	204	12	x.-x	x.-x	PROPN
eurjchem-2103	204	13	.	.	PUNCT
eurjchem-2103	205	1	anal	anal	PROPN
eurjchem-2103	205	2	.	.	PUNCT
eurjchem-2103	206	1	sci	sci	PROPN
eurjchem-2103	206	2	.	.	PROPN
eurjchem-2103	206	3	2006	2006	NUM
eurjchem-2103	206	4	,	,	PUNCT
eurjchem-2103	206	5	22	22	NUM
eurjchem-2103	206	6	,	,	PUNCT
eurjchem-2103	206	7	1515–1518	1515–1518	NUM
eurjchem-2103	206	8	.	.	PUNCT
eurjchem-2103	207	1	[	[	X
eurjchem-2103	207	2	27	27	NUM
eurjchem-2103	207	3	]	]	PUNCT
eurjchem-2103	207	4	.	.	PUNCT
eurjchem-2103	208	1	hernández	hernández	PROPN
eurjchem-2103	208	2	,	,	PUNCT
eurjchem-2103	208	3	m.	m.	NOUN
eurjchem-2103	208	4	;	;	PUNCT
eurjchem-2103	208	5	aguilar	aguilar	PROPN
eurjchem-2103	208	6	,	,	PUNCT
eurjchem-2103	208	7	c.	c.	PROPN
eurjchem-2103	208	8	;	;	PUNCT
eurjchem-2103	208	9	borrull	borrull	NOUN
eurjchem-2103	208	10	,	,	PUNCT
eurjchem-2103	208	11	f.	f.	PROPN
eurjchem-2103	208	12	;	;	PUNCT
eurjchem-2103	208	13	calull	calull	NOUN
eurjchem-2103	208	14	,	,	PUNCT
eurjchem-2103	208	15	m.	m.	PROPN
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eurjchem-2103	208	17	chromatogr	chromatogr	PROPN
eurjchem-2103	208	18	.	.	PUNCT
eurjchem-2103	209	1	b	b	PROPN
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eurjchem-2103	209	3	.	.	PUNCT
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eurjchem-2103	210	2	.	.	PROPN
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eurjchem-2103	210	4	.	.	PUNCT
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eurjchem-2103	211	2	sci	sci	PROPN
eurjchem-2103	211	3	.	.	PROPN
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eurjchem-2103	211	5	,	,	PUNCT
eurjchem-2103	211	6	772	772	NUM
eurjchem-2103	211	7	,	,	PUNCT
eurjchem-2103	211	8	163–172	163–172	NUM
eurjchem-2103	211	9	.	.	PUNCT
eurjchem-2103	212	1	[	[	X
eurjchem-2103	212	2	28	28	NUM
eurjchem-2103	212	3	]	]	PUNCT
eurjchem-2103	212	4	.	.	PUNCT
eurjchem-2103	213	1	yan	yan	PROPN
eurjchem-2103	213	2	,	,	PUNCT
eurjchem-2103	213	3	c.	c.	PROPN
eurjchem-2103	213	4	;	;	PUNCT
eurjchem-2103	213	5	tong	tong	PROPN
eurjchem-2103	213	6	,	,	PUNCT
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eurjchem-2103	213	8	;	;	PUNCT
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eurjchem-2103	213	10	,	,	PUNCT
eurjchem-2103	213	11	d.	d.	PROPN
eurjchem-2103	213	12	;	;	PUNCT
eurjchem-2103	213	13	liu	liu	PROPN
eurjchem-2103	213	14	,	,	PUNCT
eurjchem-2103	213	15	y.	y.	PROPN
eurjchem-2103	213	16	;	;	PUNCT
eurjchem-2103	213	17	pan	pan	PROPN
eurjchem-2103	213	18	,	,	PUNCT
eurjchem-2103	213	19	z.	z.	PROPN
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eurjchem-2103	213	23	,	,	PUNCT
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eurjchem-2103	213	25	,	,	PUNCT
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eurjchem-2103	213	27	–	–	PUNCT
eurjchem-2103	213	28	800	800	NUM
eurjchem-2103	213	29	.	.	PUNCT
eurjchem-2103	214	1	[	[	X
eurjchem-2103	214	2	29	29	NUM
eurjchem-2103	214	3	]	]	PUNCT
eurjchem-2103	214	4	.	.	PUNCT
eurjchem-2103	215	1	maya	maya	PROPN
eurjchem-2103	215	2	,	,	PUNCT
eurjchem-2103	215	3	m.	m.	NOUN
eurjchem-2103	215	4	t.	t.	PROPN
eurjchem-2103	215	5	;	;	PUNCT
eurjchem-2103	215	6	gonçalves	gonçalves	PROPN
eurjchem-2103	215	7	,	,	PUNCT
eurjchem-2103	215	8	n.	n.	PROPN
eurjchem-2103	215	9	j.	j.	PROPN
eurjchem-2103	215	10	;	;	PUNCT
eurjchem-2103	215	11	silva	silva	PROPN
eurjchem-2103	215	12	,	,	PUNCT
eurjchem-2103	215	13	n.	n.	PROPN
eurjchem-2103	215	14	b.	b.	PROPN
eurjchem-2103	215	15	;	;	PUNCT
eurjchem-2103	215	16	morais	morais	PROPN
eurjchem-2103	215	17	,	,	PUNCT
eurjchem-2103	215	18	j.	j.	PROPN
eurjchem-2103	215	19	a.	a.	PROPN
eurjchem-2103	215	20	j.	j.	PROPN
eurjchem-2103	215	21	chromatogr	chromatogr	PROPN
eurjchem-2103	215	22	.	.	PUNCT
eurjchem-2103	216	1	2001	2001	NUM
eurjchem-2103	216	2	,	,	PUNCT
eurjchem-2103	216	3	755	755	NUM
eurjchem-2103	216	4	,	,	PUNCT
eurjchem-2103	216	5	305–309	305–309	NUM
eurjchem-2103	216	6	.	.	PUNCT
eurjchem-2103	217	1	[	[	X
eurjchem-2103	217	2	30	30	NUM
eurjchem-2103	217	3	]	]	PUNCT
eurjchem-2103	217	4	.	.	PUNCT
eurjchem-2103	218	1	dowling	dowle	VERB
eurjchem-2103	218	2	,	,	PUNCT
eurjchem-2103	218	3	p.	p.	NOUN
eurjchem-2103	218	4	m.	m.	NOUN
eurjchem-2103	218	5	;	;	PUNCT
eurjchem-2103	218	6	wilson	wilson	PROPN
eurjchem-2103	218	7	,	,	PUNCT
eurjchem-2103	218	8	r.	r.	PROPN
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eurjchem-2103	218	10	;	;	PUNCT
eurjchem-2103	218	11	tyler	tyler	PROPN
eurjchem-2103	218	12	,	,	PUNCT
eurjchem-2103	218	13	j.	j.	PROPN
eurjchem-2103	218	14	w.	w.	PROPN
eurjchem-2103	218	15	;	;	PUNCT
eurjchem-2103	218	16	duran	duran	PROPN
eurjchem-2103	218	17	,	,	PUNCT
eurjchem-2103	218	18	s.	s.	PROPN
eurjchem-2103	218	19	h.	h.	PROPN
eurjchem-2103	218	20	j.	j.	PROPN
eurjchem-2103	218	21	vet	vet	PROPN
eurjchem-2103	218	22	.	.	PUNCT
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eurjchem-2103	219	2	.	.	PUNCT
eurjchem-2103	220	1	ther	ther	PROPN
eurjchem-2103	220	2	.	.	PUNCT
eurjchem-2103	221	1	1995	1995	NUM
eurjchem-2103	221	2	,	,	PUNCT
eurjchem-2103	221	3	18	18	NUM
eurjchem-2103	221	4	,	,	PUNCT
eurjchem-2103	221	5	7–12	7–12	PROPN
eurjchem-2103	221	6	.	.	PUNCT
eurjchem-2103	222	1	[	[	X
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eurjchem-2103	222	3	]	]	PUNCT
eurjchem-2103	222	4	.	.	PUNCT
eurjchem-2103	223	1	papich	papich	PROPN
eurjchem-2103	223	2	,	,	PUNCT
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eurjchem-2103	223	6	.	.	PUNCT
eurjchem-2103	224	1	j.	j.	PROPN
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eurjchem-2103	224	3	.	.	PUNCT
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eurjchem-2103	225	2	.	.	PROPN
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eurjchem-2103	225	4	,	,	PUNCT
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eurjchem-2103	225	6	,	,	PUNCT
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eurjchem-2103	225	8	.	.	PUNCT
eurjchem-2103	226	1	[	[	X
eurjchem-2103	226	2	32	32	NUM
eurjchem-2103	226	3	]	]	SYM
eurjchem-2103	226	4	.	.	PUNCT
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eurjchem-2103	226	6	,	,	PUNCT
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eurjchem-2103	226	10	.	.	PUNCT
eurjchem-2103	227	1	d	d	X
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eurjchem-2103	227	3	.	.	PUNCT
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eurjchem-2103	228	2	.	.	PUNCT
eurjchem-2103	229	1	2012	2012	NUM
eurjchem-2103	229	2	,	,	PUNCT
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eurjchem-2103	229	4	,	,	PUNCT
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eurjchem-2103	229	6	.	.	PUNCT
eurjchem-2103	230	1	[	[	X
eurjchem-2103	230	2	33	33	NUM
eurjchem-2103	230	3	]	]	PUNCT
eurjchem-2103	230	4	.	.	PUNCT
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eurjchem-2103	231	2	,	,	PUNCT
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eurjchem-2103	231	4	;	;	PUNCT
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eurjchem-2103	231	6	,	,	PUNCT
eurjchem-2103	231	7	p.	p.	PROPN
eurjchem-2103	231	8	;	;	PUNCT
eurjchem-2103	231	9	glen	glen	PROPN
eurjchem-2103	231	10	,	,	PUNCT
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eurjchem-2103	231	13	;	;	PUNCT
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eurjchem-2103	231	18	;	;	PUNCT
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eurjchem-2103	231	20	,	,	PUNCT
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eurjchem-2103	231	24	.	.	PUNCT
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eurjchem-2103	232	2	.	.	PUNCT
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eurjchem-2103	233	2	,	,	PUNCT
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eurjchem-2103	233	4	,	,	PUNCT
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eurjchem-2103	233	6	.	.	PUNCT
eurjchem-2103	234	1	[	[	X
eurjchem-2103	234	2	34	34	NUM
eurjchem-2103	234	3	]	]	SYM
eurjchem-2103	234	4	.	.	PUNCT
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eurjchem-2103	234	6	,	,	PUNCT
eurjchem-2103	234	7	a.	a.	NOUN
eurjchem-2103	234	8	;	;	PUNCT
eurjchem-2103	234	9	zielinski	zielinski	PROPN
eurjchem-2103	234	10	,	,	PUNCT
eurjchem-2103	234	11	k.	k.	PROPN
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eurjchem-2103	234	14	,	,	PUNCT
eurjchem-2103	234	15	b.	b.	PROPN
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eurjchem-2103	234	18	,	,	PUNCT
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eurjchem-2103	234	20	,	,	PUNCT
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eurjchem-2103	234	22	.	.	PUNCT
eurjchem-2103	235	1	[	[	X
eurjchem-2103	235	2	35	35	NUM
eurjchem-2103	235	3	]	]	PUNCT
eurjchem-2103	235	4	.	.	PUNCT
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eurjchem-2103	236	2	,	,	PUNCT
eurjchem-2103	236	3	o.	o.	PROPN
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eurjchem-2103	236	5	;	;	PUNCT
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eurjchem-2103	236	9	s.	s.	PROPN
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eurjchem-2103	236	11	;	;	PUNCT
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eurjchem-2103	236	33	.	.	PUNCT
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eurjchem-2103	237	6	.	.	PUNCT
eurjchem-2103	238	1	spectrosc	spectrosc	PROPN
eurjchem-2103	238	2	.	.	PUNCT
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eurjchem-2103	239	2	,	,	PUNCT
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eurjchem-2103	239	4	,	,	PUNCT
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eurjchem-2103	239	6	.	.	PUNCT
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eurjchem-2103	240	3	]	]	PUNCT
eurjchem-2103	240	4	.	.	PUNCT
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eurjchem-2103	241	6	.	.	PUNCT
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eurjchem-2103	242	6	,	,	PUNCT
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eurjchem-2103	242	9	.	.	PUNCT
eurjchem-2103	243	1	[	[	X
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eurjchem-2103	243	3	]	]	PUNCT
eurjchem-2103	243	4	.	.	PUNCT
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eurjchem-2103	244	2	,	,	PUNCT
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eurjchem-2103	244	4	;	;	PUNCT
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eurjchem-2103	244	6	,	,	PUNCT
eurjchem-2103	244	7	f.	f.	PROPN
eurjchem-2103	244	8	;	;	PUNCT
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eurjchem-2103	244	10	,	,	PUNCT
eurjchem-2103	244	11	h.	h.	PROPN
eurjchem-2103	244	12	;	;	PUNCT
eurjchem-2103	244	13	braz	braz	PROPN
eurjchem-2103	244	14	-	-	PUNCT
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eurjchem-2103	244	16	,	,	PUNCT
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eurjchem-2103	244	18	;	;	PUNCT
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eurjchem-2103	244	28	;	;	PUNCT
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eurjchem-2103	244	30	-	-	PUNCT
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eurjchem-2103	244	35	;	;	PUNCT
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eurjchem-2103	244	37	-	-	PUNCT
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eurjchem-2103	244	41	;	;	PUNCT
eurjchem-2103	244	42	ferreira	ferreira	PROPN
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eurjchem-2103	244	47	.	.	PUNCT
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eurjchem-2103	245	2	.	.	PUNCT
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eurjchem-2103	246	2	,	,	PUNCT
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eurjchem-2103	246	4	,	,	PUNCT
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eurjchem-2103	246	6	.	.	PUNCT
eurjchem-2103	247	1	[	[	X
eurjchem-2103	247	2	38	38	NUM
eurjchem-2103	247	3	]	]	PUNCT
eurjchem-2103	247	4	.	.	PUNCT
eurjchem-2103	248	1	yamasaki	yamasaki	PROPN
eurjchem-2103	248	2	,	,	PUNCT
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eurjchem-2103	248	4	;	;	PUNCT
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eurjchem-2103	248	6	,	,	PUNCT
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eurjchem-2103	248	10	;	;	PUNCT
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eurjchem-2103	248	14	;	;	PUNCT
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eurjchem-2103	249	2	.	.	PUNCT
eurjchem-2103	250	1	acta	acta	PROPN
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eurjchem-2103	250	3	,	,	PUNCT
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eurjchem-2103	250	5	,	,	PUNCT
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eurjchem-2103	250	7	.	.	PUNCT
eurjchem-2103	251	1	[	[	X
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eurjchem-2103	251	3	]	]	PUNCT
eurjchem-2103	251	4	.	.	PUNCT
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eurjchem-2103	252	7	,	,	PUNCT
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eurjchem-2103	254	2	.	.	PUNCT
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eurjchem-2103	255	2	,	,	PUNCT
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eurjchem-2103	255	4	,	,	PUNCT
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eurjchem-2103	255	6	.	.	PUNCT
eurjchem-2103	256	1	[	[	X
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eurjchem-2103	256	3	]	]	PUNCT
eurjchem-2103	256	4	.	.	PUNCT
eurjchem-2103	257	1	van	van	PROPN
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eurjchem-2103	257	4	,	,	PUNCT
eurjchem-2103	257	5	d.	d.	PROPN
eurjchem-2103	257	6	;	;	PUNCT
eurjchem-2103	257	7	van	van	PROPN
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eurjchem-2103	257	9	,	,	PUNCT
eurjchem-2103	257	10	p.	p.	PROPN
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eurjchem-2103	257	12	;	;	PUNCT
eurjchem-2103	257	13	larsson	larsson	PROPN
eurjchem-2103	257	14	,	,	PUNCT
eurjchem-2103	257	15	p.	p.	PROPN
eurjchem-2103	257	16	;	;	PUNCT
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eurjchem-2103	257	18	,	,	PUNCT
eurjchem-2103	257	19	n.	n.	PROPN
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eurjchem-2103	257	22	.	.	PUNCT
eurjchem-2103	258	1	chem	chem	PROPN
eurjchem-2103	258	2	.	.	PUNCT
eurjchem-2103	259	1	b	b	X
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eurjchem-2103	259	3	,	,	PUNCT
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eurjchem-2103	259	5	,	,	PUNCT
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eurjchem-2103	259	7	.	.	PUNCT
eurjchem-2103	260	1	[	[	X
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eurjchem-2103	260	3	]	]	PUNCT
eurjchem-2103	260	4	.	.	PUNCT
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eurjchem-2103	261	2	,	,	PUNCT
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eurjchem-2103	261	5	;	;	PUNCT
eurjchem-2103	261	6	neal	neal	PROPN
eurjchem-2103	261	7	,	,	PUNCT
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eurjchem-2103	261	16	.	.	PUNCT
eurjchem-2103	262	1	j.	j.	PROPN
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eurjchem-2103	262	3	,	,	PUNCT
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eurjchem-2103	262	5	,	,	PUNCT
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eurjchem-2103	262	7	.	.	PUNCT
eurjchem-2103	263	1	[	[	X
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eurjchem-2103	263	3	]	]	PUNCT
eurjchem-2103	263	4	.	.	PUNCT
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eurjchem-2103	264	2	,	,	PUNCT
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eurjchem-2103	264	5	t.	t.	PROPN
eurjchem-2103	264	6	;	;	PUNCT
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eurjchem-2103	264	14	,	,	PUNCT
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eurjchem-2103	264	19	.	.	PUNCT
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eurjchem-2103	265	2	.	.	PUNCT
eurjchem-2103	266	1	soc	soc	PROPN
eurjchem-2103	266	2	.	.	PUNCT
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eurjchem-2103	267	2	,	,	PUNCT
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eurjchem-2103	267	4	,	,	PUNCT
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eurjchem-2103	267	6	.	.	PUNCT
eurjchem-2103	268	1	[	[	X
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eurjchem-2103	268	3	]	]	PUNCT
eurjchem-2103	268	4	.	.	PUNCT
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eurjchem-2103	269	2	,	,	PUNCT
eurjchem-2103	269	3	b.	b.	PROPN
eurjchem-2103	269	4	;	;	PUNCT
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eurjchem-2103	269	6	,	,	PUNCT
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eurjchem-2103	269	8	;	;	PUNCT
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eurjchem-2103	269	17	w.	w.	PROPN
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eurjchem-2103	269	26	,	,	PUNCT
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eurjchem-2103	269	30	,	,	PUNCT
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eurjchem-2103	269	34	.	.	PUNCT
eurjchem-2103	270	1	[	[	X
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eurjchem-2103	270	3	]	]	PUNCT
eurjchem-2103	270	4	.	.	PUNCT
eurjchem-2103	271	1	naveenraj	naveenraj	ADJ
eurjchem-2103	271	2	,	,	PUNCT
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eurjchem-2103	271	4	;	;	PUNCT
eurjchem-2103	271	5	anandan	anandan	PROPN
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eurjchem-2103	271	10	.	.	PUNCT
eurjchem-2103	272	1	photobiol	photobiol	PROPN
eurjchem-2103	272	2	.	.	PUNCT
eurjchem-2103	273	1	c	c	X
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eurjchem-2103	273	4	.	.	PUNCT
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eurjchem-2103	274	4	,	,	PUNCT
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eurjchem-2103	274	6	,	,	PUNCT
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eurjchem-2103	274	8	.	.	PUNCT
eurjchem-2103	275	1	[	[	X
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eurjchem-2103	275	3	]	]	PUNCT
eurjchem-2103	275	4	.	.	PUNCT
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eurjchem-2103	276	5	;	;	PUNCT
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eurjchem-2103	276	7	,	,	PUNCT
eurjchem-2103	276	8	a.	a.	NOUN
eurjchem-2103	276	9	;	;	PUNCT
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eurjchem-2103	276	12	n.	n.	PROPN
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eurjchem-2103	276	15	.	.	PUNCT
eurjchem-2103	277	1	chem	chem	PROPN
eurjchem-2103	277	2	.	.	PUNCT
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eurjchem-2103	278	3	,	,	PUNCT
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eurjchem-2103	278	5	,	,	PUNCT
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eurjchem-2103	278	7	–	–	PUNCT
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eurjchem-2103	278	9	.	.	PUNCT
eurjchem-2103	279	1	[	[	X
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eurjchem-2103	279	3	]	]	PUNCT
eurjchem-2103	279	4	.	.	PUNCT
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eurjchem-2103	281	2	.	.	PUNCT
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eurjchem-2103	282	4	,	,	PUNCT
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eurjchem-2103	282	8	.	.	PUNCT
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eurjchem-2103	285	7	are	be	AUX
eurjchem-2103	285	8	available	available	ADJ
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eurjchem-2103	285	11	and	and	CCONJ
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eurjchem-2103	285	20	(	(	PUNCT
eurjchem-2103	285	21	cc	cc	NOUN
eurjchem-2103	285	22	by	by	ADP
eurjchem-2103	285	23	nc	nc	PROPN
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eurjchem-2103	285	25	(	(	PUNCT
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eurjchem-2103	285	31	(	(	PUNCT
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eurjchem-2103	286	4	work	work	NOUN
eurjchem-2103	286	5	,	,	PUNCT
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eurjchem-2103	286	10	terms	term	NOUN
eurjchem-2103	286	11	.	.	PUNCT
eurjchem-2103	287	1	this	this	PRON
eurjchem-2103	287	2	is	be	AUX
eurjchem-2103	287	3	an	an	DET
eurjchem-2103	287	4	open	open	ADJ
eurjchem-2103	287	5	access	access	NOUN
eurjchem-2103	287	6	article	article	NOUN
eurjchem-2103	287	7	distributed	distribute	VERB
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eurjchem-2103	287	9	the	the	DET
eurjchem-2103	287	10	terms	term	NOUN
eurjchem-2103	287	11	and	and	CCONJ
eurjchem-2103	287	12	conditions	condition	NOUN
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eurjchem-2103	287	15	cc	cc	PROPN
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eurjchem-2103	287	17	nc	nc	PROPN
eurjchem-2103	287	18	license	license	PROPN
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eurjchem-2103	287	32	in	in	ADP
eurjchem-2103	287	33	any	any	DET
eurjchem-2103	287	34	medium	medium	NOUN
eurjchem-2103	287	35	,	,	PUNCT
eurjchem-2103	287	36	provided	provide	VERB
eurjchem-2103	287	37	the	the	DET
eurjchem-2103	287	38	original	original	ADJ
eurjchem-2103	287	39	work	work	NOUN
eurjchem-2103	287	40	is	be	AUX
eurjchem-2103	287	41	properly	properly	ADV
eurjchem-2103	287	42	cited	cite	VERB
eurjchem-2103	287	43	without	without	ADP
eurjchem-2103	287	44	any	any	DET
eurjchem-2103	287	45	further	further	ADJ
eurjchem-2103	287	46	permission	permission	NOUN
eurjchem-2103	287	47	from	from	ADP
eurjchem-2103	287	48	atlanta	atlanta	PROPN
eurjchem-2103	287	49	publishing	publishing	PROPN
eurjchem-2103	287	50	house	house	PROPN
eurjchem-2103	287	51	llc	llc	PROPN
eurjchem-2103	287	52	(	(	PUNCT
eurjchem-2103	287	53	european	european	PROPN
eurjchem-2103	287	54	journal	journal	PROPN
eurjchem-2103	287	55	of	of	ADP
eurjchem-2103	287	56	chemistry	chemistry	NOUN
eurjchem-2103	287	57	)	)	PUNCT
eurjchem-2103	287	58	.	.	PUNCT
eurjchem-2103	288	1	no	no	DET
eurjchem-2103	288	2	use	use	NOUN
eurjchem-2103	288	3	,	,	PUNCT
eurjchem-2103	288	4	distribution	distribution	NOUN
eurjchem-2103	288	5	or	or	CCONJ
eurjchem-2103	288	6	reproduction	reproduction	NOUN
eurjchem-2103	288	7	is	be	AUX
eurjchem-2103	288	8	permitted	permit	VERB
eurjchem-2103	288	9	which	which	PRON
eurjchem-2103	288	10	does	do	AUX
eurjchem-2103	288	11	not	not	PART
eurjchem-2103	288	12	comply	comply	VERB
eurjchem-2103	288	13	with	with	ADP
eurjchem-2103	288	14	these	these	DET
eurjchem-2103	288	15	terms	term	NOUN
eurjchem-2103	288	16	.	.	PUNCT
eurjchem-2103	289	1	permissions	permission	NOUN
eurjchem-2103	289	2	for	for	ADP
eurjchem-2103	289	3	commercial	commercial	ADJ
eurjchem-2103	289	4	use	use	NOUN
eurjchem-2103	289	5	of	of	ADP
eurjchem-2103	289	6	this	this	DET
eurjchem-2103	289	7	work	work	NOUN
eurjchem-2103	289	8	beyond	beyond	ADP
eurjchem-2103	289	9	the	the	DET
eurjchem-2103	289	10	scope	scope	NOUN
eurjchem-2103	289	11	of	of	ADP
eurjchem-2103	289	12	the	the	DET
eurjchem-2103	289	13	license	license	NOUN
eurjchem-2103	289	14	(	(	PUNCT
eurjchem-2103	289	15	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	NOUN
eurjchem-2103	289	16	)	)	PUNCT
eurjchem-2103	289	17	are	be	AUX
eurjchem-2103	289	18	administered	administer	VERB
eurjchem-2103	289	19	by	by	ADP
eurjchem-2103	289	20	atlanta	atlanta	PROPN
eurjchem-2103	289	21	publishing	publishing	PROPN
eurjchem-2103	289	22	house	house	PROPN
eurjchem-2103	289	23	llc	llc	PROPN
eurjchem-2103	289	24	(	(	PUNCT
eurjchem-2103	289	25	european	european	PROPN
eurjchem-2103	289	26	journal	journal	PROPN
eurjchem-2103	289	27	of	of	ADP
eurjchem-2103	289	28	chemistry	chemistry	NOUN
eurjchem-2103	289	29	)	)	PUNCT
eurjchem-2103	289	30	.	.	PUNCT
eurjchem-2103	290	1	https://orcid.org/0000-0001-6211-7659	https://orcid.org/0000-0001-6211-7659	PROPN
eurjchem-2103	290	2	https://orcid.org/0000-0002-1306-2644	https://orcid.org/0000-0002-1306-2644	NOUN
eurjchem-2103	290	3	http://www.pharmasm.com/pdf_files/%2020140729051511_20_swatantra.pdf	http://www.pharmasm.com/pdf_files/%2020140729051511_20_swatantra.pdf	NOUN
eurjchem-2103	290	4	http://www.pharmasm.com/pdf_files/%2020140729051511_20_swatantra.pdf	http://www.pharmasm.com/pdf_files/%2020140729051511_20_swatantra.pdf	NOUN
eurjchem-2103	290	5	https://www.ema.europa.eu/en/committees/%20committee-medicinal-products-veterinary-use-cvmp	https://www.ema.europa.eu/en/committees/%20committee-medicinal-products-veterinary-use-cvmp	X
eurjchem-2103	290	6	https://www.ema.europa.eu/en/committees/%20committee-medicinal-products-veterinary-use-cvmp	https://www.ema.europa.eu/en/committees/%20committee-medicinal-products-veterinary-use-cvmp	PROPN
eurjchem-2103	290	7	https://pymol.org/2/	https://pymol.org/2/	PROPN
eurjchem-2103	290	8	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	VERB
eurjchem-2103	290	9	http://creativecommons.org/licenses/by-nc/4.0	http://creativecommons.org/licenses/by-nc/4.0	PROPN
eurjchem-2103	290	10	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	NOUN
eurjchem-2103	290	11	1	1	NUM
eurjchem-2103	290	12	.	.	PUNCT
eurjchem-2103	291	1	introduction	introduction	NOUN
eurjchem-2103	291	2	2	2	NUM
eurjchem-2103	291	3	.	.	PUNCT
eurjchem-2103	291	4	experimental	experimental	ADJ
eurjchem-2103	291	5	2.1	2.1	NUM
eurjchem-2103	291	6	.	.	PUNCT
eurjchem-2103	292	1	molecular	molecular	ADJ
eurjchem-2103	292	2	descriptor	descriptor	NOUN
eurjchem-2103	292	3	calculation	calculation	NOUN
eurjchem-2103	292	4	3	3	NUM
eurjchem-2103	292	5	.	.	NOUN
eurjchem-2103	292	6	results	result	NOUN
eurjchem-2103	292	7	and	and	CCONJ
eurjchem-2103	292	8	discussion	discussion	NOUN
eurjchem-2103	292	9	4	4	NUM
eurjchem-2103	292	10	.	.	PUNCT
eurjchem-2103	293	1	conclusions	conclusion	NOUN
eurjchem-2103	293	2	acknowledgements	acknowledgement	VERB
eurjchem-2103	293	3	disclosure	disclosure	NOUN
eurjchem-2103	293	4	statement	statement	NOUN
eurjchem-2103	293	5	funding	fund	VERB
eurjchem-2103	293	6	orcid	orcid	PROPN
eurjchem-2103	293	7	references	reference	NOUN
eurjchem-2103	293	8	printfield10	printfield10	NOUN
eurjchem-2103	293	9	:	:	PUNCT
eurjchem-2103	293	10	printfield11	printfield11	NOUN
eurjchem-2103	293	11	:	:	PUNCT
eurjchem-2103	293	12	printfield12	printfield12	PROPN
eurjchem-2103	293	13	:	:	PUNCT
eurjchem-2103	293	14	printfield13	printfield13	VERB
eurjchem-2103	293	15	:	:	PUNCT
eurjchem-2103	293	16	printfield14	printfield14	NOUN
eurjchem-2103	293	17	:	:	PUNCT
eurjchem-2103	293	18	printfield20	printfield20	PROPN
eurjchem-2103	293	19	:	:	PUNCT
eurjchem-2103	293	20	printfield21	printfield21	ADJ
eurjchem-2103	293	21	:	:	PUNCT
eurjchem-2103	293	22	printfield22	printfield22	NOUN
eurjchem-2103	293	23	:	:	PUNCT
eurjchem-2103	293	24	printfield23	printfield23	NOUN
eurjchem-2103	293	25	:	:	PUNCT
eurjchem-2103	293	26	printfield24	printfield24	NOUN
eurjchem-2103	293	27	:	:	PUNCT