id	sid	tid	token	lemma	pos
eurjchem-2350	1	1	quinoline	quinoline	NOUN
eurjchem-2350	1	2	analogue	analogue	NOUN
eurjchem-2350	1	3	as	as	ADP
eurjchem-2350	1	4	a	a	DET
eurjchem-2350	1	5	potential	potential	ADJ
eurjchem-2350	1	6	inhibitor	inhibitor	NOUN
eurjchem-2350	1	7	of	of	ADP
eurjchem-2350	1	8	sars	sar	NOUN
eurjchem-2350	1	9	-	-	PUNCT
eurjchem-2350	1	10	cov-2	cov-2	NOUN
eurjchem-2350	1	11	main	main	ADJ
eurjchem-2350	1	12	protease	protease	NOUN
eurjchem-2350	1	13	:	:	PUNCT
eurjchem-2350	1	14	admet	admet	PROPN
eurjchem-2350	1	15	prediction	prediction	NOUN
eurjchem-2350	1	16	,	,	PUNCT
eurjchem-2350	1	17	molecular	molecular	ADJ
eurjchem-2350	1	18	docking	docking	NOUN
eurjchem-2350	1	19	and	and	CCONJ
eurjchem-2350	1	20	dynamics	dynamic	NOUN
eurjchem-2350	1	21	simulation	simulation	NOUN
eurjchem-2350	1	22	analysis	analysis	PROPN
eurjchem-2350	1	23	european	european	PROPN
eurjchem-2350	1	24	journal	journal	PROPN
eurjchem-2350	1	25	of	of	ADP
eurjchem-2350	1	26	chemistry	chemistry	NOUN
eurjchem-2350	1	27	14	14	NUM
eurjchem-2350	1	28	(	(	PUNCT
eurjchem-2350	1	29	1	1	NUM
eurjchem-2350	1	30	)	)	PUNCT
eurjchem-2350	1	31	(	(	PUNCT
eurjchem-2350	1	32	2023	2023	NUM
eurjchem-2350	1	33	)	)	PUNCT
eurjchem-2350	1	34	30	30	NUM
eurjchem-2350	1	35	-	-	SYM
eurjchem-2350	1	36	38	38	NUM
eurjchem-2350	1	37	european	european	ADJ
eurjchem-2350	1	38	journal	journal	NOUN
eurjchem-2350	1	39	of	of	ADP
eurjchem-2350	1	40	chemistry	chemistry	NOUN
eurjchem-2350	1	41	issn	issn	VERB
eurjchem-2350	1	42	2153	2153	NUM
eurjchem-2350	1	43	-	-	SYM
eurjchem-2350	1	44	2249	2249	NUM
eurjchem-2350	1	45	(	(	PUNCT
eurjchem-2350	1	46	print	print	NOUN
eurjchem-2350	1	47	)	)	PUNCT
eurjchem-2350	1	48	/	/	PUNCT
eurjchem-2350	1	49	issn	issn	PROPN
eurjchem-2350	1	50	2153	2153	NUM
eurjchem-2350	1	51	-	-	SYM
eurjchem-2350	1	52	2257	2257	NUM
eurjchem-2350	1	53	(	(	PUNCT
eurjchem-2350	1	54	online	online	ADJ
eurjchem-2350	1	55	)	)	PUNCT
eurjchem-2350	1	56	–	–	PUNCT
eurjchem-2350	2	1	copyright	copyright	NOUN
eurjchem-2350	2	2	©	©	PROPN
eurjchem-2350	2	3	2023	2023	NUM
eurjchem-2350	2	4	the	the	DET
eurjchem-2350	2	5	authors	author	NOUN
eurjchem-2350	2	6	–	–	PUNCT
eurjchem-2350	2	7	atlanta	atlanta	PROPN
eurjchem-2350	2	8	publishing	publishing	PROPN
eurjchem-2350	2	9	house	house	PROPN
eurjchem-2350	2	10	llc	llc	PROPN
eurjchem-2350	2	11	–	–	PUNCT
eurjchem-2350	2	12	printed	print	VERB
eurjchem-2350	2	13	in	in	ADP
eurjchem-2350	2	14	the	the	DET
eurjchem-2350	2	15	usa	usa	PROPN
eurjchem-2350	2	16	.	.	PUNCT
eurjchem-2350	3	1	this	this	DET
eurjchem-2350	3	2	work	work	NOUN
eurjchem-2350	3	3	is	be	AUX
eurjchem-2350	3	4	published	publish	VERB
eurjchem-2350	3	5	and	and	CCONJ
eurjchem-2350	3	6	licensed	license	VERB
eurjchem-2350	3	7	by	by	ADP
eurjchem-2350	3	8	atlanta	atlanta	PROPN
eurjchem-2350	3	9	publishing	publishing	PROPN
eurjchem-2350	3	10	house	house	PROPN
eurjchem-2350	3	11	llc	llc	PROPN
eurjchem-2350	3	12	–	–	PUNCT
eurjchem-2350	3	13	cc	cc	PROPN
eurjchem-2350	3	14	by	by	ADP
eurjchem-2350	3	15	nc	nc	PROPN
eurjchem-2350	3	16	–	–	PUNCT
eurjchem-2350	3	17	some	some	DET
eurjchem-2350	3	18	rights	right	NOUN
eurjchem-2350	3	19	reserved	reserve	VERB
eurjchem-2350	3	20	.	.	PUNCT
eurjchem-2350	4	1	https://dx.doi.org/10.5155/eurjchem.14.1.30-38.2350	https://dx.doi.org/10.5155/eurjchem.14.1.30-38.2350	PROPN
eurjchem-2350	4	2	european	european	PROPN
eurjchem-2350	4	3	journal	journal	PROPN
eurjchem-2350	4	4	of	of	ADP
eurjchem-2350	4	5	chemistry	chemistry	NOUN
eurjchem-2350	4	6	view	view	NOUN
eurjchem-2350	4	7	journal	journal	PROPN
eurjchem-2350	4	8	online	online	PROPN
eurjchem-2350	4	9	view	view	NOUN
eurjchem-2350	4	10	article	article	NOUN
eurjchem-2350	4	11	online	online	ADJ
eurjchem-2350	4	12	quinoline	quinoline	PROPN
eurjchem-2350	4	13	analogue	analogue	NOUN
eurjchem-2350	4	14	as	as	ADP
eurjchem-2350	4	15	a	a	DET
eurjchem-2350	4	16	potential	potential	ADJ
eurjchem-2350	4	17	inhibitor	inhibitor	NOUN
eurjchem-2350	4	18	of	of	ADP
eurjchem-2350	4	19	sars	sar	NOUN
eurjchem-2350	4	20	-	-	PUNCT
eurjchem-2350	4	21	cov-2	cov-2	NOUN
eurjchem-2350	4	22	main	main	ADJ
eurjchem-2350	4	23	protease	protease	NOUN
eurjchem-2350	4	24	:	:	PUNCT
eurjchem-2350	4	25	admet	admet	PROPN
eurjchem-2350	4	26	prediction	prediction	NOUN
eurjchem-2350	4	27	,	,	PUNCT
eurjchem-2350	4	28	molecular	molecular	ADJ
eurjchem-2350	4	29	docking	docking	NOUN
eurjchem-2350	4	30	and	and	CCONJ
eurjchem-2350	4	31	dynamics	dynamic	NOUN
eurjchem-2350	4	32	simulation	simulation	NOUN
eurjchem-2350	4	33	analysis	analysis	NOUN
eurjchem-2350	4	34	praveen	praveen	PROPN
eurjchem-2350	4	35	kumar	kumar	PROPN
eurjchem-2350	4	36	1	1	NUM
eurjchem-2350	4	37	,	,	PUNCT
eurjchem-2350	4	38	santhosha	santhosha	PROPN
eurjchem-2350	4	39	sangapurada	sangapurada	PROPN
eurjchem-2350	4	40	mahantheshappa	mahantheshappa	VERB
eurjchem-2350	4	41	2	2	NUM
eurjchem-2350	4	42	,	,	PUNCT
eurjchem-2350	4	43	sakthivel	sakthivel	NOUN
eurjchem-2350	4	44	balasubramaniyan	balasubramaniyan	NOUN
eurjchem-2350	4	45	3	3	NUM
eurjchem-2350	4	46	,	,	PUNCT
eurjchem-2350	4	47	nayak	nayak	PROPN
eurjchem-2350	4	48	devappa	devappa	PROPN
eurjchem-2350	4	49	satyanarayan	satyanarayan	PROPN
eurjchem-2350	4	50	2	2	NUM
eurjchem-2350	4	51	and	and	CCONJ
eurjchem-2350	4	52	rajeshwara	rajeshwara	PROPN
eurjchem-2350	4	53	achur	achur	NOUN
eurjchem-2350	4	54	1	1	NUM
eurjchem-2350	4	55	,	,	PUNCT
eurjchem-2350	4	56	*	*	PROPN
eurjchem-2350	4	57	1	1	NUM
eurjchem-2350	4	58	department	department	NOUN
eurjchem-2350	4	59	of	of	ADP
eurjchem-2350	4	60	biochemistry	biochemistry	NOUN
eurjchem-2350	4	61	,	,	PUNCT
eurjchem-2350	4	62	kuvempu	kuvempu	PROPN
eurjchem-2350	4	63	university	university	PROPN
eurjchem-2350	4	64	,	,	PUNCT
eurjchem-2350	4	65	jnana	jnana	NOUN
eurjchem-2350	4	66	sahyadri-577451	sahyadri-577451	ADV
eurjchem-2350	4	67	,	,	PUNCT
eurjchem-2350	4	68	shimoga	shimoga	PROPN
eurjchem-2350	4	69	,	,	PUNCT
eurjchem-2350	4	70	karnataka	karnataka	PROPN
eurjchem-2350	4	71	,	,	PUNCT
eurjchem-2350	4	72	india	india	PROPN
eurjchem-2350	4	73	2	2	NUM
eurjchem-2350	4	74	department	department	NOUN
eurjchem-2350	4	75	of	of	ADP
eurjchem-2350	4	76	pharmaceutical	pharmaceutical	ADJ
eurjchem-2350	4	77	chemistry	chemistry	NOUN
eurjchem-2350	4	78	,	,	PUNCT
eurjchem-2350	4	79	kuvempu	kuvempu	PROPN
eurjchem-2350	4	80	university	university	PROPN
eurjchem-2350	4	81	post	post	PROPN
eurjchem-2350	4	82	graduate	graduate	PROPN
eurjchem-2350	4	83	centre	centre	NOUN
eurjchem-2350	4	84	,	,	PUNCT
eurjchem-2350	4	85	kadur-577458	kadur-577458	NOUN
eurjchem-2350	4	86	,	,	PUNCT
eurjchem-2350	4	87	chikkamagaluru	chikkamagaluru	NOUN
eurjchem-2350	4	88	district	district	NOUN
eurjchem-2350	4	89	,	,	PUNCT
eurjchem-2350	4	90	karnataka-577458	karnataka-577458	PROPN
eurjchem-2350	4	91	,	,	PUNCT
eurjchem-2350	4	92	india	india	PROPN
eurjchem-2350	4	93	3	3	NUM
eurjchem-2350	4	94	drug	drug	NOUN
eurjchem-2350	4	95	discovery	discovery	NOUN
eurjchem-2350	4	96	and	and	CCONJ
eurjchem-2350	4	97	development	development	NOUN
eurjchem-2350	4	98	research	research	NOUN
eurjchem-2350	4	99	group	group	NOUN
eurjchem-2350	4	100	,	,	PUNCT
eurjchem-2350	4	101	department	department	NOUN
eurjchem-2350	4	102	of	of	ADP
eurjchem-2350	4	103	pharmaceutical	pharmaceutical	NOUN
eurjchem-2350	4	104	technology	technology	NOUN
eurjchem-2350	4	105	,	,	PUNCT
eurjchem-2350	4	106	university	university	NOUN
eurjchem-2350	4	107	college	college	NOUN
eurjchem-2350	4	108	of	of	ADP
eurjchem-2350	4	109	engineering	engineering	PROPN
eurjchem-2350	4	110	,	,	PUNCT
eurjchem-2350	4	111	anna	anna	PROPN
eurjchem-2350	4	112	university	university	PROPN
eurjchem-2350	4	113	,	,	PUNCT
eurjchem-2350	4	114	tiruchirapalli-62024	tiruchirapalli-62024	NOUN
eurjchem-2350	4	115	,	,	PUNCT
eurjchem-2350	4	116	tamilnadu	tamilnadu	ADJ
eurjchem-2350	4	117	,	,	PUNCT
eurjchem-2350	4	118	india	india	PROPN
eurjchem-2350	4	119	*	*	PUNCT
eurjchem-2350	4	120	corresponding	correspond	VERB
eurjchem-2350	4	121	author	author	NOUN
eurjchem-2350	4	122	at	at	ADP
eurjchem-2350	4	123	:	:	PUNCT
eurjchem-2350	4	124	department	department	NOUN
eurjchem-2350	4	125	of	of	ADP
eurjchem-2350	4	126	biochemistry	biochemistry	NOUN
eurjchem-2350	4	127	,	,	PUNCT
eurjchem-2350	4	128	kuvempu	kuvempu	PROPN
eurjchem-2350	4	129	university	university	PROPN
eurjchem-2350	4	130	,	,	PUNCT
eurjchem-2350	4	131	jnana	jnana	NOUN
eurjchem-2350	4	132	sahyadri-577451	sahyadri-577451	ADV
eurjchem-2350	4	133	,	,	PUNCT
eurjchem-2350	4	134	shimoga	shimoga	PROPN
eurjchem-2350	4	135	,	,	PUNCT
eurjchem-2350	4	136	karnataka	karnataka	PROPN
eurjchem-2350	4	137	,	,	PUNCT
eurjchem-2350	4	138	india	india	PROPN
eurjchem-2350	4	139	.	.	PUNCT
eurjchem-2350	5	1	e	e	X
eurjchem-2350	5	2	-	-	NOUN
eurjchem-2350	5	3	mail	mail	NOUN
eurjchem-2350	5	4	:	:	PUNCT
eurjchem-2350	6	1	rajachur@gmail.com	rajachur@gmail.com	X
eurjchem-2350	6	2	(	(	PUNCT
eurjchem-2350	6	3	r.	r.	PROPN
eurjchem-2350	6	4	achur	achur	PROPN
eurjchem-2350	6	5	)	)	PUNCT
eurjchem-2350	6	6	.	.	PUNCT
eurjchem-2350	7	1	10.5155	10.5155	NUM
eurjchem-2350	7	2	/	/	SYM
eurjchem-2350	7	3	eurjchem.14.1.30	eurjchem.14.1.30	PROPN
eurjchem-2350	7	4	-	-	PUNCT
eurjchem-2350	7	5	38.2350	38.2350	NUM
eurjchem-2350	7	6	received	receive	VERB
eurjchem-2350	7	7	:	:	PUNCT
eurjchem-2350	7	8	24	24	NUM
eurjchem-2350	7	9	september	september	PROPN
eurjchem-2350	7	10	2022	2022	NUM
eurjchem-2350	7	11	received	receive	VERB
eurjchem-2350	7	12	in	in	ADP
eurjchem-2350	7	13	revised	revise	VERB
eurjchem-2350	7	14	form	form	NOUN
eurjchem-2350	7	15	:	:	PUNCT
eurjchem-2350	7	16	30	30	NUM
eurjchem-2350	7	17	october	october	NOUN
eurjchem-2350	7	18	2022	2022	NUM
eurjchem-2350	7	19	accepted	accept	VERB
eurjchem-2350	7	20	:	:	PUNCT
eurjchem-2350	7	21	08	08	NUM
eurjchem-2350	7	22	november	november	PROPN
eurjchem-2350	7	23	2022	2022	NUM
eurjchem-2350	7	24	published	publish	VERB
eurjchem-2350	7	25	online	online	ADV
eurjchem-2350	7	26	:	:	PUNCT
eurjchem-2350	7	27	31	31	NUM
eurjchem-2350	7	28	march	march	NOUN
eurjchem-2350	7	29	2023	2023	NUM
eurjchem-2350	7	30	printed	print	VERB
eurjchem-2350	7	31	:	:	PUNCT
eurjchem-2350	7	32	31	31	NUM
eurjchem-2350	7	33	march	march	NOUN
eurjchem-2350	7	34	2023	2023	NUM
eurjchem-2350	7	35	the	the	DET
eurjchem-2350	7	36	novel	novel	ADJ
eurjchem-2350	7	37	coronavirus	coronavirus	NOUN
eurjchem-2350	7	38	(	(	PUNCT
eurjchem-2350	7	39	covid-19	covid-19	PROPN
eurjchem-2350	7	40	)	)	PUNCT
eurjchem-2350	7	41	has	have	AUX
eurjchem-2350	7	42	triggered	trigger	VERB
eurjchem-2350	7	43	a	a	DET
eurjchem-2350	7	44	major	major	ADJ
eurjchem-2350	7	45	human	human	ADJ
eurjchem-2350	7	46	turmoil	turmoil	NOUN
eurjchem-2350	7	47	worldwide	worldwide	ADV
eurjchem-2350	7	48	by	by	ADP
eurjchem-2350	7	49	posing	pose	VERB
eurjchem-2350	7	50	challenges	challenge	NOUN
eurjchem-2350	7	51	regarding	regard	VERB
eurjchem-2350	7	52	infection	infection	NOUN
eurjchem-2350	7	53	prevention	prevention	NOUN
eurjchem-2350	7	54	,	,	PUNCT
eurjchem-2350	7	55	disease	disease	NOUN
eurjchem-2350	7	56	diagnosis	diagnosis	NOUN
eurjchem-2350	7	57	,	,	PUNCT
eurjchem-2350	7	58	and	and	CCONJ
eurjchem-2350	7	59	treatment	treatment	NOUN
eurjchem-2350	7	60	.	.	PUNCT
eurjchem-2350	8	1	several	several	ADJ
eurjchem-2350	8	2	drugs	drug	NOUN
eurjchem-2350	8	3	including	include	VERB
eurjchem-2350	8	4	remdesivir	remdesivir	NOUN
eurjchem-2350	8	5	(	(	PUNCT
eurjchem-2350	8	6	rdv	rdv	PROPN
eurjchem-2350	8	7	)	)	PUNCT
eurjchem-2350	8	8	,	,	PUNCT
eurjchem-2350	8	9	hydroxychloroquine	hydroxychloroquine	PROPN
eurjchem-2350	8	10	(	(	PUNCT
eurjchem-2350	8	11	hcq	hcq	NOUN
eurjchem-2350	8	12	)	)	PUNCT
eurjchem-2350	8	13	,	,	PUNCT
eurjchem-2350	8	14	and	and	CCONJ
eurjchem-2350	8	15	others	other	NOUN
eurjchem-2350	8	16	are	be	AUX
eurjchem-2350	8	17	being	be	AUX
eurjchem-2350	8	18	used	use	VERB
eurjchem-2350	8	19	to	to	PART
eurjchem-2350	8	20	treat	treat	VERB
eurjchem-2350	8	21	covid-19	covid-19	PROPN
eurjchem-2350	8	22	,	,	PUNCT
eurjchem-2350	8	23	although	although	SCONJ
eurjchem-2350	8	24	these	these	PRON
eurjchem-2350	8	25	are	be	AUX
eurjchem-2350	8	26	not	not	PART
eurjchem-2350	8	27	specifically	specifically	ADV
eurjchem-2350	8	28	proven	prove	VERB
eurjchem-2350	8	29	drugs	drug	NOUN
eurjchem-2350	8	30	.	.	PUNCT
eurjchem-2350	9	1	thus	thus	ADV
eurjchem-2350	9	2	,	,	PUNCT
eurjchem-2350	9	3	it	it	PRON
eurjchem-2350	9	4	is	be	AUX
eurjchem-2350	9	5	very	very	ADV
eurjchem-2350	9	6	critical	critical	ADJ
eurjchem-2350	9	7	to	to	PART
eurjchem-2350	9	8	understand	understand	VERB
eurjchem-2350	9	9	covid-19	covid-19	PROPN
eurjchem-2350	9	10	drug	drug	NOUN
eurjchem-2350	9	11	targets	target	NOUN
eurjchem-2350	9	12	and	and	CCONJ
eurjchem-2350	9	13	their	their	PRON
eurjchem-2350	9	14	interactions	interaction	NOUN
eurjchem-2350	9	15	with	with	ADP
eurjchem-2350	9	16	candidate	candidate	NOUN
eurjchem-2350	9	17	drugs	drug	NOUN
eurjchem-2350	9	18	.	.	PUNCT
eurjchem-2350	10	1	here	here	ADV
eurjchem-2350	10	2	,	,	PUNCT
eurjchem-2350	10	3	we	we	PRON
eurjchem-2350	10	4	attempted	attempt	VERB
eurjchem-2350	10	5	in	in	ADP
eurjchem-2350	10	6	silico	silico	NOUN
eurjchem-2350	10	7	screening	screen	VERB
eurjchem-2350	10	8	of	of	ADP
eurjchem-2350	10	9	ten	ten	NUM
eurjchem-2350	10	10	quinoline	quinoline	NOUN
eurjchem-2350	10	11	analogs	analog	NOUN
eurjchem-2350	10	12	(	(	PUNCT
eurjchem-2350	10	13	q1	q1	PROPN
eurjchem-2350	10	14	-	-	PUNCT
eurjchem-2350	10	15	q10	q10	NOUN
eurjchem-2350	10	16	)	)	PUNCT
eurjchem-2350	10	17	against	against	ADP
eurjchem-2350	10	18	the	the	DET
eurjchem-2350	10	19	five	five	NUM
eurjchem-2350	10	20	main	main	ADJ
eurjchem-2350	10	21	proteases	protease	NOUN
eurjchem-2350	10	22	of	of	ADP
eurjchem-2350	10	23	sars	sar	NOUN
eurjchem-2350	10	24	-	-	PUNCT
eurjchem-2350	10	25	cov-2	cov-2	NUM
eurjchem-2350	10	26	by	by	ADP
eurjchem-2350	10	27	docking	docking	NOUN
eurjchem-2350	10	28	and	and	CCONJ
eurjchem-2350	10	29	dynamics	dynamic	NOUN
eurjchem-2350	10	30	analysis	analysis	NOUN
eurjchem-2350	10	31	.	.	PUNCT
eurjchem-2350	11	1	the	the	DET
eurjchem-2350	11	2	prediction	prediction	NOUN
eurjchem-2350	11	3	of	of	ADP
eurjchem-2350	11	4	the	the	DET
eurjchem-2350	11	5	admet	admet	PROPN
eurjchem-2350	11	6	profile	profile	NOUN
eurjchem-2350	11	7	showed	show	VERB
eurjchem-2350	11	8	that	that	SCONJ
eurjchem-2350	11	9	the	the	DET
eurjchem-2350	11	10	best	well	ADV
eurjchem-2350	11	11	docked	docked	ADJ
eurjchem-2350	11	12	quinolines	quinoline	NOUN
eurjchem-2350	11	13	are	be	AUX
eurjchem-2350	11	14	safe	safe	ADJ
eurjchem-2350	11	15	and	and	CCONJ
eurjchem-2350	11	16	possess	possess	VERB
eurjchem-2350	11	17	drug	drug	NOUN
eurjchem-2350	11	18	-	-	PUNCT
eurjchem-2350	11	19	like	like	ADJ
eurjchem-2350	11	20	properties	property	NOUN
eurjchem-2350	11	21	.	.	PUNCT
eurjchem-2350	12	1	the	the	DET
eurjchem-2350	12	2	molecular	molecular	ADJ
eurjchem-2350	12	3	interaction	interaction	NOUN
eurjchem-2350	12	4	and	and	CCONJ
eurjchem-2350	12	5	binding	bind	VERB
eurjchem-2350	12	6	affinity	affinity	NOUN
eurjchem-2350	12	7	of	of	ADP
eurjchem-2350	12	8	these	these	DET
eurjchem-2350	12	9	small	small	ADJ
eurjchem-2350	12	10	molecules	molecule	NOUN
eurjchem-2350	12	11	were	be	AUX
eurjchem-2350	12	12	determined	determine	VERB
eurjchem-2350	12	13	with	with	ADP
eurjchem-2350	12	14	respect	respect	NOUN
eurjchem-2350	12	15	to	to	ADP
eurjchem-2350	12	16	the	the	DET
eurjchem-2350	12	17	five	five	NUM
eurjchem-2350	12	18	protease	protease	NOUN
eurjchem-2350	12	19	(	(	PUNCT
eurjchem-2350	12	20	mpro	mpro	ADJ
eurjchem-2350	12	21	)	)	PUNCT
eurjchem-2350	12	22	targets	target	NOUN
eurjchem-2350	12	23	of	of	ADP
eurjchem-2350	12	24	sars	sar	NOUN
eurjchem-2350	12	25	-	-	PUNCT
eurjchem-2350	12	26	cov-2	cov-2	PUNCT
eurjchem-2350	12	27	(	(	PUNCT
eurjchem-2350	12	28	pdb	pdb	PROPN
eurjchem-2350	12	29	i	i	PROPN
eurjchem-2350	12	30	d	d	PROPN
eurjchem-2350	12	31	:	:	PUNCT
eurjchem-2350	12	32	6lu7	6lu7	NUM
eurjchem-2350	12	33	,	,	PUNCT
eurjchem-2350	12	34	6w63	6w63	NUM
eurjchem-2350	12	35	,	,	PUNCT
eurjchem-2350	12	36	6m03	6m03	NOUN
eurjchem-2350	12	37	,	,	PUNCT
eurjchem-2350	12	38	6y84	6y84	NOUN
eurjchem-2350	12	39	and	and	CCONJ
eurjchem-2350	12	40	6yb7	6yb7	NUM
eurjchem-2350	12	41	)	)	PUNCT
eurjchem-2350	12	42	.	.	PUNCT
eurjchem-2350	13	1	the	the	DET
eurjchem-2350	13	2	study	study	NOUN
eurjchem-2350	13	3	indicated	indicate	VERB
eurjchem-2350	13	4	that	that	SCONJ
eurjchem-2350	13	5	the	the	DET
eurjchem-2350	13	6	quinoline	quinoline	NOUN
eurjchem-2350	13	7	ligands	ligand	NOUN
eurjchem-2350	13	8	q4	q4	PROPN
eurjchem-2350	13	9	,	,	PUNCT
eurjchem-2350	13	10	q5	q5	PROPN
eurjchem-2350	13	11	,	,	PUNCT
eurjchem-2350	13	12	q6	q6	PROPN
eurjchem-2350	13	13	,	,	PUNCT
eurjchem-2350	13	14	q7	q7	PROPN
eurjchem-2350	13	15	,	,	PUNCT
eurjchem-2350	13	16	q8	q8	PROPN
eurjchem-2350	13	17	,	,	PUNCT
eurjchem-2350	13	18	q9	q9	PROPN
eurjchem-2350	13	19	,	,	PUNCT
eurjchem-2350	13	20	and	and	CCONJ
eurjchem-2350	13	21	q10as	q10as	PRON
eurjchem-2350	13	22	probable	probable	ADJ
eurjchem-2350	13	23	inhibitors	inhibitor	NOUN
eurjchem-2350	13	24	against	against	ADP
eurjchem-2350	13	25	sars	sar	NOUN
eurjchem-2350	13	26	-	-	PUNCT
eurjchem-2350	13	27	cov-2	cov-2	NOUN
eurjchem-2350	13	28	mpro	mpro	ADJ
eurjchem-2350	13	29	and	and	CCONJ
eurjchem-2350	13	30	showed	show	VERB
eurjchem-2350	13	31	favorable	favorable	ADJ
eurjchem-2350	13	32	binding	bind	VERB
eurjchem-2350	13	33	interaction	interaction	NOUN
eurjchem-2350	13	34	with	with	ADP
eurjchem-2350	13	35	the	the	DET
eurjchem-2350	13	36	amino	amino	NOUN
eurjchem-2350	13	37	acid	acid	NOUN
eurjchem-2350	13	38	glu166	glu166	NOUN
eurjchem-2350	13	39	of	of	ADP
eurjchem-2350	13	40	6y84	6y84	NOUN
eurjchem-2350	13	41	,	,	PUNCT
eurjchem-2350	13	42	6lu7and	6lu7and	NUM
eurjchem-2350	13	43	6m03	6m03	NOUN
eurjchem-2350	13	44	.	.	PUNCT
eurjchem-2350	14	1	furthermore	furthermore	ADV
eurjchem-2350	14	2	,	,	PUNCT
eurjchem-2350	14	3	q9	q9	PROPN
eurjchem-2350	14	4	has	have	VERB
eurjchem-2350	14	5	a	a	DET
eurjchem-2350	14	6	highly	highly	ADV
eurjchem-2350	14	7	significant	significant	ADJ
eurjchem-2350	14	8	docking	docking	NOUN
eurjchem-2350	14	9	score	score	NOUN
eurjchem-2350	14	10	and	and	CCONJ
eurjchem-2350	14	11	binding	bind	VERB
eurjchem-2350	14	12	affinity	affinity	NOUN
eurjchem-2350	14	13	with	with	ADP
eurjchem-2350	14	14	all	all	DET
eurjchem-2350	14	15	fivecovid-19	fivecovid-19	PROPN
eurjchem-2350	14	16	receptors	receptor	NOUN
eurjchem-2350	14	17	having	have	VERB
eurjchem-2350	14	18	a	a	DET
eurjchem-2350	14	19	minimum	minimum	NOUN
eurjchem-2350	14	20	of	of	ADP
eurjchem-2350	14	21	two	two	NUM
eurjchem-2350	14	22	h	h	NOUN
eurjchem-2350	14	23	-	-	PUNCT
eurjchem-2350	14	24	bonds	bond	NOUN
eurjchem-2350	14	25	,	,	PUNCT
eurjchem-2350	14	26	which	which	PRON
eurjchem-2350	14	27	is	be	AUX
eurjchem-2350	14	28	remarkable	remarkable	ADJ
eurjchem-2350	14	29	compared	compare	VERB
eurjchem-2350	14	30	to	to	ADP
eurjchem-2350	14	31	hcq	hcq	PROPN
eurjchem-2350	14	32	,	,	PUNCT
eurjchem-2350	14	33	rdv	rdv	NOUN
eurjchem-2350	14	34	,	,	PUNCT
eurjchem-2350	14	35	and	and	CCONJ
eurjchem-2350	14	36	other	other	ADJ
eurjchem-2350	14	37	quinolines	quinoline	NOUN
eurjchem-2350	14	38	.	.	PUNCT
eurjchem-2350	15	1	the	the	DET
eurjchem-2350	15	2	dynamics	dynamic	NOUN
eurjchem-2350	15	3	simulation	simulation	NOUN
eurjchem-2350	15	4	analysis	analysis	NOUN
eurjchem-2350	15	5	of	of	ADP
eurjchem-2350	15	6	this	this	DET
eurjchem-2350	15	7	potent	potent	ADJ
eurjchem-2350	15	8	drug	drug	NOUN
eurjchem-2350	15	9	candidate	candidate	NOUN
eurjchem-2350	15	10	q9	q9	NOUN
eurjchem-2350	15	11	with	with	ADP
eurjchem-2350	15	12	6lu7	6lu7	NUM
eurjchem-2350	15	13	indicated	indicate	VERB
eurjchem-2350	15	14	high	high	ADJ
eurjchem-2350	15	15	stability	stability	NOUN
eurjchem-2350	15	16	of	of	ADP
eurjchem-2350	15	17	the	the	DET
eurjchem-2350	15	18	complex	complex	NOUN
eurjchem-2350	15	19	.	.	PUNCT
eurjchem-2350	16	1	in	in	ADP
eurjchem-2350	16	2	conclusion	conclusion	NOUN
eurjchem-2350	16	3	,	,	PUNCT
eurjchem-2350	16	4	our	our	PRON
eurjchem-2350	16	5	findings	finding	NOUN
eurjchem-2350	16	6	indicate	indicate	VERB
eurjchem-2350	16	7	that	that	SCONJ
eurjchem-2350	16	8	all	all	PRON
eurjchem-2350	16	9	of	of	ADP
eurjchem-2350	16	10	these	these	DET
eurjchem-2350	16	11	quinolines	quinoline	NOUN
eurjchem-2350	16	12	in	in	ADP
eurjchem-2350	16	13	general	general	ADJ
eurjchem-2350	16	14	possess	possess	VERB
eurjchem-2350	16	15	good	good	ADJ
eurjchem-2350	16	16	binding	bind	VERB
eurjchem-2350	16	17	affinity	affinity	NOUN
eurjchem-2350	16	18	and	and	CCONJ
eurjchem-2350	16	19	q9	q9	PROPN
eurjchem-2350	16	20	can	can	AUX
eurjchem-2350	16	21	serve	serve	VERB
eurjchem-2350	16	22	as	as	ADP
eurjchem-2350	16	23	a	a	DET
eurjchem-2350	16	24	good	good	ADJ
eurjchem-2350	16	25	quinoline	quinoline	NOUN
eurjchem-2350	16	26	scaffold	scaffold	NOUN
eurjchem-2350	16	27	for	for	ADP
eurjchem-2350	16	28	the	the	DET
eurjchem-2350	16	29	design	design	NOUN
eurjchem-2350	16	30	of	of	ADP
eurjchem-2350	16	31	new	new	ADJ
eurjchem-2350	16	32	antiviral	antiviral	ADJ
eurjchem-2350	16	33	agents	agent	NOUN
eurjchem-2350	16	34	to	to	PART
eurjchem-2350	16	35	target	target	VERB
eurjchem-2350	16	36	the	the	DET
eurjchem-2350	16	37	active	active	ADJ
eurjchem-2350	16	38	site	site	NOUN
eurjchem-2350	16	39	of	of	ADP
eurjchem-2350	16	40	sars	sar	NOUN
eurjchem-2350	16	41	-	-	PUNCT
eurjchem-2350	16	42	cov-2	cov-2	NOUN
eurjchem-2350	16	43	mpro	mpro	ADJ
eurjchem-2350	16	44	.	.	PUNCT
eurjchem-2350	17	1	qikprop	qikprop	PROPN
eurjchem-2350	17	2	quinoline	quinoline	PROPN
eurjchem-2350	17	3	covid-19	covid-19	PROPN
eurjchem-2350	17	4	remdesivir	remdesivir	PROPN
eurjchem-2350	17	5	sars	sars	PROPN
eurjchem-2350	17	6	-	-	PUNCT
eurjchem-2350	17	7	cov-2	cov-2	PART
eurjchem-2350	17	8	hydroxychloroquine	hydroxychloroquine	NOUN
eurjchem-2350	17	9	cite	cite	VERB
eurjchem-2350	17	10	this	this	PRON
eurjchem-2350	17	11	:	:	PUNCT
eurjchem-2350	17	12	eur	eur	PROPN
eurjchem-2350	17	13	.	.	PUNCT
eurjchem-2350	18	1	j.	j.	PROPN
eurjchem-2350	18	2	chem	chem	PROPN
eurjchem-2350	18	3	.	.	PUNCT
eurjchem-2350	19	1	2023	2023	NUM
eurjchem-2350	19	2	,	,	PUNCT
eurjchem-2350	19	3	14(1	14(1	NUM
eurjchem-2350	19	4	)	)	PUNCT
eurjchem-2350	19	5	,	,	PUNCT
eurjchem-2350	19	6	30	30	NUM
eurjchem-2350	19	7	-	-	SYM
eurjchem-2350	19	8	38	38	NUM
eurjchem-2350	19	9	journal	journal	NOUN
eurjchem-2350	19	10	website	website	NOUN
eurjchem-2350	19	11	:	:	PUNCT
eurjchem-2350	19	12	www.eurjchem.com	www.eurjchem.com	X
eurjchem-2350	19	13	1	1	X
eurjchem-2350	19	14	.	.	X
eurjchem-2350	19	15	introduction	introduction	NOUN
eurjchem-2350	19	16	the	the	DET
eurjchem-2350	19	17	novel	novel	ADJ
eurjchem-2350	19	18	coronavirus	coronavirus	NOUN
eurjchem-2350	19	19	sars	sar	NOUN
eurjchem-2350	19	20	-	-	PUNCT
eurjchem-2350	19	21	cov-2	cov-2	PART
eurjchem-2350	19	22	is	be	AUX
eurjchem-2350	19	23	the	the	DET
eurjchem-2350	19	24	causative	causative	ADJ
eurjchem-2350	19	25	agent	agent	NOUN
eurjchem-2350	19	26	responsible	responsible	ADJ
eurjchem-2350	19	27	for	for	ADP
eurjchem-2350	19	28	“	"	PUNCT
eurjchem-2350	19	29	covid-19	covid-19	PROPN
eurjchem-2350	19	30	”	"	PUNCT
eurjchem-2350	19	31	viral	viral	ADJ
eurjchem-2350	19	32	pneumonia	pneumonia	NOUN
eurjchem-2350	19	33	outbreak	outbreak	NOUN
eurjchem-2350	19	34	which	which	PRON
eurjchem-2350	19	35	was	be	AUX
eurjchem-2350	19	36	first	first	ADV
eurjchem-2350	19	37	detected	detect	VERB
eurjchem-2350	19	38	in	in	ADP
eurjchem-2350	19	39	china	china	PROPN
eurjchem-2350	19	40	during	during	ADP
eurjchem-2350	19	41	2019	2019	NUM
eurjchem-2350	19	42	-	-	SYM
eurjchem-2350	19	43	2020	2020	NUM
eurjchem-2350	19	44	[	[	X
eurjchem-2350	19	45	1	1	NUM
eurjchem-2350	19	46	]	]	PUNCT
eurjchem-2350	19	47	.	.	PUNCT
eurjchem-2350	20	1	covid-19	covid-19	PROPN
eurjchem-2350	20	2	infection	infection	NOUN
eurjchem-2350	20	3	has	have	AUX
eurjchem-2350	20	4	become	become	VERB
eurjchem-2350	20	5	a	a	DET
eurjchem-2350	20	6	serious	serious	ADJ
eurjchem-2350	20	7	public	public	ADJ
eurjchem-2350	20	8	health	health	NOUN
eurjchem-2350	20	9	concern	concern	NOUN
eurjchem-2350	20	10	around	around	ADP
eurjchem-2350	20	11	the	the	DET
eurjchem-2350	20	12	world	world	NOUN
eurjchem-2350	20	13	.	.	PUNCT
eurjchem-2350	21	1	according	accord	VERB
eurjchem-2350	21	2	to	to	ADP
eurjchem-2350	21	3	the	the	DET
eurjchem-2350	21	4	united	united	PROPN
eurjchem-2350	21	5	states	states	PROPN
eurjchem-2350	21	6	food	food	PROPN
eurjchem-2350	21	7	and	and	CCONJ
eurjchem-2350	21	8	drug	drug	PROPN
eurjchem-2350	21	9	administration	administration	NOUN
eurjchem-2350	21	10	(	(	PUNCT
eurjchem-2350	21	11	fda	fda	PROPN
eurjchem-2350	21	12	)	)	PUNCT
eurjchem-2350	21	13	,	,	PUNCT
eurjchem-2350	21	14	there	there	PRON
eurjchem-2350	21	15	are	be	VERB
eurjchem-2350	21	16	several	several	ADJ
eurjchem-2350	21	17	covid-19	covid-19	PROPN
eurjchem-2350	21	18	treatments	treatment	NOUN
eurjchem-2350	21	19	currently	currently	ADV
eurjchem-2350	21	20	authorized	authorize	VERB
eurjchem-2350	21	21	for	for	ADP
eurjchem-2350	21	22	emergency	emergency	NOUN
eurjchem-2350	21	23	use	use	NOUN
eurjchem-2350	21	24	and	and	CCONJ
eurjchem-2350	21	25	there	there	PRON
eurjchem-2350	21	26	are	be	VERB
eurjchem-2350	21	27	only	only	ADV
eurjchem-2350	21	28	a	a	DET
eurjchem-2350	21	29	few	few	ADJ
eurjchem-2350	21	30	viable	viable	ADJ
eurjchem-2350	21	31	treatment	treatment	NOUN
eurjchem-2350	21	32	options	option	NOUN
eurjchem-2350	21	33	[	[	X
eurjchem-2350	21	34	2	2	NUM
eurjchem-2350	21	35	]	]	PUNCT
eurjchem-2350	21	36	.	.	PUNCT
eurjchem-2350	22	1	to	to	PART
eurjchem-2350	22	2	test	test	VERB
eurjchem-2350	22	3	their	their	PRON
eurjchem-2350	22	4	antiviral	antiviral	ADJ
eurjchem-2350	22	5	effectiveness	effectiveness	NOUN
eurjchem-2350	22	6	by	by	ADP
eurjchem-2350	22	7	repurposing	repurpose	VERB
eurjchem-2350	22	8	,	,	PUNCT
eurjchem-2350	22	9	many	many	ADJ
eurjchem-2350	22	10	drugs	drug	NOUN
eurjchem-2350	22	11	are	be	AUX
eurjchem-2350	22	12	undergoing	undergo	VERB
eurjchem-2350	22	13	clinical	clinical	ADJ
eurjchem-2350	22	14	trials	trial	NOUN
eurjchem-2350	22	15	including	include	VERB
eurjchem-2350	22	16	hydroxychloroquine	hydroxychloroquine	NOUN
eurjchem-2350	22	17	(	(	PUNCT
eurjchem-2350	22	18	hcq	hcq	NOUN
eurjchem-2350	22	19	)	)	PUNCT
eurjchem-2350	22	20	,	,	PUNCT
eurjchem-2350	22	21	chloroquine	chloroquine	NOUN
eurjchem-2350	22	22	(	(	PUNCT
eurjchem-2350	22	23	cq	cq	NOUN
eurjchem-2350	22	24	)	)	PUNCT
eurjchem-2350	22	25	,	,	PUNCT
eurjchem-2350	22	26	and	and	CCONJ
eurjchem-2350	22	27	remdesivir	remdesivir	NOUN
eurjchem-2350	22	28	(	(	PUNCT
eurjchem-2350	22	29	rdv	rdv	NOUN
eurjchem-2350	22	30	)	)	PUNCT
eurjchem-2350	23	1	[	[	X
eurjchem-2350	23	2	3	3	NUM
eurjchem-2350	23	3	]	]	PUNCT
eurjchem-2350	23	4	.	.	PUNCT
eurjchem-2350	24	1	based	base	VERB
eurjchem-2350	24	2	on	on	ADP
eurjchem-2350	24	3	the	the	DET
eurjchem-2350	24	4	preliminary	preliminary	ADJ
eurjchem-2350	24	5	clinical	clinical	ADJ
eurjchem-2350	24	6	trial	trial	NOUN
eurjchem-2350	24	7	findings	finding	NOUN
eurjchem-2350	24	8	and	and	CCONJ
eurjchem-2350	24	9	cell	cell	NOUN
eurjchem-2350	24	10	culture	culture	NOUN
eurjchem-2350	24	11	studies	study	NOUN
eurjchem-2350	24	12	[	[	X
eurjchem-2350	24	13	4	4	NUM
eurjchem-2350	24	14	]	]	PUNCT
eurjchem-2350	24	15	,	,	PUNCT
eurjchem-2350	24	16	the	the	DET
eurjchem-2350	24	17	widely	widely	ADV
eurjchem-2350	24	18	used	use	VERB
eurjchem-2350	24	19	70	70	NUM
eurjchem-2350	24	20	-	-	SYM
eurjchem-2350	24	21	yearold	yearold	ADJ
eurjchem-2350	24	22	malaria	malaria	NOUN
eurjchem-2350	24	23	medications	medication	NOUN
eurjchem-2350	24	24	,	,	PUNCT
eurjchem-2350	24	25	cq	cq	NOUN
eurjchem-2350	24	26	and	and	CCONJ
eurjchem-2350	24	27	hcq	hcq	NOUN
eurjchem-2350	24	28	,	,	PUNCT
eurjchem-2350	24	29	have	have	AUX
eurjchem-2350	24	30	been	be	AUX
eurjchem-2350	24	31	found	find	VERB
eurjchem-2350	24	32	to	to	PART
eurjchem-2350	24	33	exhibit	exhibit	VERB
eurjchem-2350	24	34	potential	potential	ADJ
eurjchem-2350	24	35	therapeutic	therapeutic	ADJ
eurjchem-2350	24	36	efficacy	efficacy	NOUN
eurjchem-2350	24	37	against	against	ADP
eurjchem-2350	24	38	covid-19[5	covid-19[5	ADV
eurjchem-2350	24	39	]	]	PUNCT
eurjchem-2350	24	40	.	.	PUNCT
eurjchem-2350	25	1	in	in	ADP
eurjchem-2350	25	2	addition	addition	NOUN
eurjchem-2350	25	3	,	,	PUNCT
eurjchem-2350	25	4	rdv	rdv	NOUN
eurjchem-2350	25	5	,	,	PUNCT
eurjchem-2350	25	6	a	a	DET
eurjchem-2350	25	7	nucleoside	nucleoside	ADJ
eurjchem-2350	25	8	analogue	analogue	NOUN
eurjchem-2350	25	9	,	,	PUNCT
eurjchem-2350	25	10	has	have	AUX
eurjchem-2350	25	11	also	also	ADV
eurjchem-2350	25	12	been	be	AUX
eurjchem-2350	25	13	used	use	VERB
eurjchem-2350	25	14	against	against	ADP
eurjchem-2350	25	15	covid-19infection	covid-19infection	NOUN
eurjchem-2350	25	16	[	[	X
eurjchem-2350	25	17	6	6	NUM
eurjchem-2350	25	18	]	]	PUNCT
eurjchem-2350	25	19	.	.	PUNCT
eurjchem-2350	26	1	rdv	rdv	NOUN
eurjchem-2350	26	2	has	have	VERB
eurjchem-2350	26	3	a	a	DET
eurjchem-2350	26	4	wide	wide	ADJ
eurjchem-2350	26	5	spectrum	spectrum	NOUN
eurjchem-2350	26	6	of	of	ADP
eurjchem-2350	26	7	activities	activity	NOUN
eurjchem-2350	26	8	in	in	ADP
eurjchem-2350	26	9	cell	cell	NOUN
eurjchem-2350	26	10	cultures	culture	NOUN
eurjchem-2350	26	11	and	and	CCONJ
eurjchem-2350	26	12	animal	animal	NOUN
eurjchem-2350	26	13	models	model	NOUN
eurjchem-2350	26	14	against	against	ADP
eurjchem-2350	26	15	rna	rna	NOUN
eurjchem-2350	26	16	viruses	virus	NOUN
eurjchem-2350	26	17	such	such	ADJ
eurjchem-2350	26	18	as	as	ADP
eurjchem-2350	26	19	mers	mer	NOUN
eurjchem-2350	26	20	and	and	CCONJ
eurjchem-2350	26	21	sars	sar	NOUN
eurjchem-2350	26	22	and	and	CCONJ
eurjchem-2350	26	23	was	be	AUX
eurjchem-2350	26	24	tested	test	VERB
eurjchem-2350	26	25	in	in	ADP
eurjchem-2350	26	26	a	a	DET
eurjchem-2350	26	27	clinical	clinical	ADJ
eurjchem-2350	26	28	trial	trial	NOUN
eurjchem-2350	26	29	for	for	ADP
eurjchem-2350	26	30	ebola	ebola	NOUN
eurjchem-2350	27	1	[	[	X
eurjchem-2350	27	2	7,8	7,8	NUM
eurjchem-2350	27	3	]	]	PUNCT
eurjchem-2350	27	4	.	.	PUNCT
eurjchem-2350	28	1	rdv	rdv	NOUN
eurjchem-2350	28	2	has	have	AUX
eurjchem-2350	28	3	also	also	ADV
eurjchem-2350	28	4	shown	show	VERB
eurjchem-2350	28	5	its	its	PRON
eurjchem-2350	28	6	antiviral	antiviral	ADJ
eurjchem-2350	28	7	potential	potential	NOUN
eurjchem-2350	28	8	against	against	ADP
eurjchem-2350	28	9	sars	sar	NOUN
eurjchem-2350	28	10	-	-	PUNCT
eurjchem-2350	28	11	cov-2	cov-2	NOUN
eurjchem-2350	28	12	in	in	ADP
eurjchem-2350	28	13	vitro	vitro	X
eurjchem-2350	28	14	with	with	ADP
eurjchem-2350	28	15	an	an	DET
eurjchem-2350	28	16	estimated	estimate	VERB
eurjchem-2350	28	17	50	50	NUM
eurjchem-2350	28	18	%	%	NOUN
eurjchem-2350	28	19	effective	effective	ADJ
eurjchem-2350	28	20	concentration	concentration	NOUN
eurjchem-2350	28	21	at	at	ADP
eurjchem-2350	28	22	23.15μm	23.15μm	NUM
eurjchem-2350	28	23	[	[	X
eurjchem-2350	28	24	9	9	NUM
eurjchem-2350	28	25	]	]	PUNCT
eurjchem-2350	28	26	.	.	PUNCT
eurjchem-2350	29	1	in	in	ADP
eurjchem-2350	29	2	mediating	mediate	VERB
eurjchem-2350	29	3	viral	viral	ADJ
eurjchem-2350	29	4	replication	replication	NOUN
eurjchem-2350	29	5	and	and	CCONJ
eurjchem-2350	29	6	transcription	transcription	NOUN
eurjchem-2350	29	7	,	,	PUNCT
eurjchem-2350	29	8	cq	cq	PROPN
eurjchem-2350	29	9	plays	play	VERB
eurjchem-2350	29	10	a	a	DET
eurjchem-2350	29	11	key	key	ADJ
eurjchem-2350	29	12	role	role	NOUN
eurjchem-2350	29	13	and	and	CCONJ
eurjchem-2350	29	14	makes	make	VERB
eurjchem-2350	29	15	this	this	DET
eurjchem-2350	29	16	virus	virus	NOUN
eurjchem-2350	29	17	as	as	ADP
eurjchem-2350	29	18	an	an	DET
eurjchem-2350	29	19	appropriate	appropriate	ADJ
eurjchem-2350	29	20	target	target	NOUN
eurjchem-2350	29	21	[	[	X
eurjchem-2350	29	22	10	10	NUM
eurjchem-2350	29	23	]	]	PUNCT
eurjchem-2350	29	24	.	.	PUNCT
eurjchem-2350	30	1	the	the	DET
eurjchem-2350	30	2	cq	cq	PROPN
eurjchem-2350	30	3	may	may	AUX
eurjchem-2350	30	4	also	also	ADV
eurjchem-2350	30	5	interfere	interfere	VERB
eurjchem-2350	30	6	with	with	ADP
eurjchem-2350	30	7	viral	viral	ADJ
eurjchem-2350	30	8	particles	particle	NOUN
eurjchem-2350	30	9	that	that	PRON
eurjchem-2350	30	10	attach	attach	VERB
eurjchem-2350	30	11	to	to	ADP
eurjchem-2350	30	12	their	their	PRON
eurjchem-2350	30	13	cellular	cellular	ADJ
eurjchem-2350	30	14	cell	cell	NOUN
eurjchem-2350	30	15	surface	surface	NOUN
eurjchem-2350	30	16	receptors	receptor	NOUN
eurjchem-2350	30	17	by	by	ADP
eurjchem-2350	30	18	inhibiting	inhibit	VERB
eurjchem-2350	30	19	a	a	DET
eurjchem-2350	30	20	step	step	NOUN
eurjchem-2350	30	21	before	before	ADP
eurjchem-2350	30	22	the	the	DET
eurjchem-2350	30	23	viral	viral	ADJ
eurjchem-2350	30	24	cycle	cycle	NOUN
eurjchem-2350	30	25	[	[	X
eurjchem-2350	30	26	11	11	NUM
eurjchem-2350	30	27	]	]	PUNCT
eurjchem-2350	30	28	.	.	PUNCT
eurjchem-2350	31	1	hcq	hcq	PROPN
eurjchem-2350	31	2	is	be	AUX
eurjchem-2350	31	3	a	a	DET
eurjchem-2350	31	4	drug	drug	NOUN
eurjchem-2350	31	5	that	that	PRON
eurjchem-2350	31	6	is	be	AUX
eurjchem-2350	31	7	less	less	ADV
eurjchem-2350	31	8	toxic	toxic	ADJ
eurjchem-2350	31	9	and	and	CCONJ
eurjchem-2350	31	10	safe	safe	ADJ
eurjchem-2350	31	11	to	to	ADP
eurjchem-2350	31	12	against	against	ADP
eurjchem-2350	31	13	covid-19	covid-19	PROPN
eurjchem-2350	31	14	pneumonia	pneumonia	NOUN
eurjchem-2350	31	15	,	,	PUNCT
eurjchem-2350	31	16	with	with	ADP
eurjchem-2350	31	17	increasing	increase	VERB
eurjchem-2350	31	18	reports	report	NOUN
eurjchem-2350	31	19	supporting	support	VERB
eurjchem-2350	31	20	its	its	PRON
eurjchem-2350	31	21	use	use	NOUN
eurjchem-2350	31	22	in	in	ADP
eurjchem-2350	31	23	patients	patient	NOUN
eurjchem-2350	31	24	with	with	ADP
eurjchem-2350	31	25	moderate	moderate	ADJ
eurjchem-2350	31	26	to	to	ADP
eurjchem-2350	31	27	severe	severe	ADJ
eurjchem-2350	31	28	diseases	disease	NOUN
eurjchem-2350	31	29	.	.	PUNCT
eurjchem-2350	32	1	the	the	DET
eurjchem-2350	32	2	advantage	advantage	NOUN
eurjchem-2350	32	3	of	of	ADP
eurjchem-2350	32	4	hcq	hcq	NOUN
eurjchem-2350	32	5	is	be	AUX
eurjchem-2350	32	6	that	that	SCONJ
eurjchem-2350	32	7	it	it	PRON
eurjchem-2350	32	8	can	can	AUX
eurjchem-2350	32	9	be	be	AUX
eurjchem-2350	32	10	used	use	VERB
eurjchem-2350	32	11	in	in	ADP
eurjchem-2350	32	12	high	high	ADJ
eurjchem-2350	32	13	doses	dose	NOUN
eurjchem-2350	32	14	for	for	ADP
eurjchem-2350	32	15	long	long	ADJ
eurjchem-2350	32	16	periods	period	NOUN
eurjchem-2350	32	17	with	with	ADP
eurjchem-2350	32	18	very	very	ADV
eurjchem-2350	32	19	good	good	ADJ
eurjchem-2350	32	20	tolerance	tolerance	NOUN
eurjchem-2350	32	21	levels	level	NOUN
eurjchem-2350	32	22	[	[	X
eurjchem-2350	32	23	12	12	NUM
eurjchem-2350	32	24	]	]	PUNCT
eurjchem-2350	32	25	.	.	PUNCT
eurjchem-2350	33	1	in	in	ADP
eurjchem-2350	33	2	vitro	vitro	X
eurjchem-2350	33	3	,	,	PUNCT
eurjchem-2350	33	4	cq	cq	PROPN
eurjchem-2350	33	5	appears	appear	VERB
eurjchem-2350	33	6	as	as	ADP
eurjchem-2350	33	7	a	a	DET
eurjchem-2350	33	8	versatile	versatile	ADJ
eurjchem-2350	33	9	bioactive	bioactive	ADJ
eurjchem-2350	33	10	agent	agent	NOUN
eurjchem-2350	33	11	that	that	PRON
eurjchem-2350	33	12	has	have	VERB
eurjchem-2350	33	13	antiviral	antiviral	ADJ
eurjchem-2350	33	14	activity	activity	NOUN
eurjchem-2350	33	15	[	[	X
eurjchem-2350	33	16	13	13	NUM
eurjchem-2350	33	17	]	]	PUNCT
eurjchem-2350	33	18	against	against	ADP
eurjchem-2350	33	19	rna	rna	NOUN
eurjchem-2350	33	20	viruses	virus	NOUN
eurjchem-2350	33	21	as	as	ADV
eurjchem-2350	33	22	diverse	diverse	ADJ
eurjchem-2350	33	23	as	as	ADP
eurjchem-2350	33	24	rabies	rabie	NOUN
eurjchem-2350	33	25	virus	virus	NOUN
eurjchem-2350	33	26	[	[	X
eurjchem-2350	33	27	14	14	NUM
eurjchem-2350	33	28	]	]	PUNCT
eurjchem-2350	33	29	,	,	PUNCT
eurjchem-2350	33	30	poliovirus	poliovirus	NOUN
eurjchem-2350	34	1	[	[	X
eurjchem-2350	34	2	15	15	NUM
eurjchem-2350	34	3	]	]	X
eurjchem-2350	34	4	,	,	PUNCT
eurjchem-2350	34	5	hiv	hiv	PROPN
eurjchem-2350	35	1	[	[	X
eurjchem-2350	35	2	16	16	NUM
eurjchem-2350	35	3	]	]	PUNCT
eurjchem-2350	35	4	,	,	PUNCT
eurjchem-2350	35	5	hepatitis	hepatitis	NOUN
eurjchem-2350	35	6	a	a	DET
eurjchem-2350	35	7	virus	virus	NOUN
eurjchem-2350	36	1	[	[	X
eurjchem-2350	36	2	17	17	NUM
eurjchem-2350	36	3	]	]	PUNCT
eurjchem-2350	36	4	,	,	PUNCT
eurjchem-2350	36	5	zika	zika	X
eurjchem-2350	36	6	virus	virus	NOUN
eurjchem-2350	36	7	[	[	X
eurjchem-2350	36	8	18	18	NUM
eurjchem-2350	36	9	]	]	PUNCT
eurjchem-2350	36	10	and	and	CCONJ
eurjchem-2350	36	11	ebola	ebola	PROPN
eurjchem-2350	36	12	virus	virus	NOUN
eurjchem-2350	37	1	[	[	X
eurjchem-2350	37	2	19	19	NUM
eurjchem-2350	37	3	]	]	PUNCT
eurjchem-2350	37	4	.	.	PUNCT
eurjchem-2350	38	1	regarding	regard	VERB
eurjchem-2350	38	2	corona	corona	NOUN
eurjchem-2350	38	3	viruses	virus	NOUN
eurjchem-2350	38	4	,	,	PUNCT
eurjchem-2350	38	5	the	the	DET
eurjchem-2350	38	6	potential	potential	ADJ
eurjchem-2350	38	7	therapeutic	therapeutic	ADJ
eurjchem-2350	38	8	benefits	benefit	NOUN
eurjchem-2350	38	9	of	of	ADP
eurjchem-2350	38	10	cq	cq	PROPN
eurjchem-2350	38	11	were	be	AUX
eurjchem-2350	38	12	notably	notably	ADV
eurjchem-2350	38	13	reported	report	VERB
eurjchem-2350	38	14	for	for	ADP
eurjchem-2350	38	15	sars	sar	NOUN
eurjchem-2350	38	16	-	-	PUNCT
eurjchem-2350	38	17	cov-1	cov-1	ADJ
eurjchem-2350	38	18	[	[	X
eurjchem-2350	38	19	10,21	10,21	NUM
eurjchem-2350	38	20	]	]	PUNCT
eurjchem-2350	38	21	.	.	PUNCT
eurjchem-2350	39	1	considering	consider	VERB
eurjchem-2350	39	2	the	the	DET
eurjchem-2350	39	3	specific	specific	ADJ
eurjchem-2350	39	4	chemical	chemical	NOUN
eurjchem-2350	39	5	structures	structure	NOUN
eurjchem-2350	39	6	and	and	CCONJ
eurjchem-2350	39	7	mechanisms	mechanism	NOUN
eurjchem-2350	39	8	of	of	ADP
eurjchem-2350	39	9	action	action	NOUN
eurjchem-2350	39	10	of	of	ADP
eurjchem-2350	39	11	cq	cq	NOUN
eurjchem-2350	39	12	and	and	CCONJ
eurjchem-2350	39	13	hcq	hcq	NOUN
eurjchem-2350	39	14	as	as	ADP
eurjchem-2350	39	15	weak	weak	ADJ
eurjchem-2350	39	16	bases	basis	NOUN
eurjchem-2350	39	17	and	and	CCONJ
eurjchem-2350	39	18	their	their	PRON
eurjchem-2350	39	19	immunomodulatory	immunomodulatory	ADJ
eurjchem-2350	39	20	activity	activity	NOUN
eurjchem-2350	39	21	,	,	PUNCT
eurjchem-2350	39	22	hcq	hcq	NOUN
eurjchem-2350	39	23	molecule	molecule	NOUN
eurjchem-2350	39	24	may	may	AUX
eurjchem-2350	39	25	be	be	AUX
eurjchem-2350	39	26	a	a	DET
eurjchem-2350	39	27	strong	strong	ADJ
eurjchem-2350	39	28	likely	likely	ADJ
eurjchem-2350	39	29	candidate	candidate	NOUN
eurjchem-2350	39	30	for	for	ADP
eurjchem-2350	39	31	the	the	DET
eurjchem-2350	39	32	treatment	treatment	NOUN
eurjchem-2350	39	33	of	of	ADP
eurjchem-2350	39	34	covid-19	covid-19	PROPN
eurjchem-2350	39	35	infections	infection	NOUN
eurjchem-2350	39	36	.	.	PUNCT
eurjchem-2350	40	1	however	however	ADV
eurjchem-2350	40	2	,	,	PUNCT
eurjchem-2350	40	3	currently	currently	ADV
eurjchem-2350	40	4	,	,	PUNCT
eurjchem-2350	40	5	the	the	DET
eurjchem-2350	40	6	study	study	NOUN
eurjchem-2350	40	7	of	of	ADP
eurjchem-2350	40	8	hcq	hcq	PROPN
eurjchem-2350	40	9	is	be	AUX
eurjchem-2350	40	10	limited	limit	VERB
eurjchem-2350	40	11	to	to	ADP
eurjchem-2350	40	12	clinical	clinical	ADJ
eurjchem-2350	40	13	trials	trial	NOUN
eurjchem-2350	40	14	and	and	CCONJ
eurjchem-2350	40	15	,	,	PUNCT
eurjchem-2350	40	16	based	base	VERB
eurjchem-2350	40	17	on	on	ADP
eurjchem-2350	40	18	its	its	PRON
eurjchem-2350	40	19	use	use	NOUN
eurjchem-2350	40	20	outside	outside	ADV
eurjchem-2350	40	21	of	of	ADP
eurjchem-2350	40	22	clinical	clinical	ADJ
eurjchem-2350	40	23	trials	trial	NOUN
eurjchem-2350	40	24	,	,	PUNCT
eurjchem-2350	40	25	risks	risk	NOUN
eurjchem-2350	40	26	,	,	PUNCT
eurjchem-2350	40	27	and	and	CCONJ
eurjchem-2350	40	28	abstract	abstract	ADJ
eurjchem-2350	40	29	research	research	NOUN
eurjchem-2350	40	30	article	article	NOUN
eurjchem-2350	40	31	keywords	keyword	VERB
eurjchem-2350	40	32	https://dx.doi.org/10.5155/eurjchem.14.1.30-38.2350	https://dx.doi.org/10.5155/eurjchem.14.1.30-38.2350	PROPN
eurjchem-2350	40	33	https://www.eurjchem.com/	https://www.eurjchem.com/	VERB
eurjchem-2350	40	34	https://dx.doi.org/10.5155/eurjchem.14.1.30-38.2350	https://dx.doi.org/10.5155/eurjchem.14.1.30-38.2350	PROPN
eurjchem-2350	40	35	mailto:rajachur@gmail.com	mailto:rajachur@gmail.com	PROPN
eurjchem-2350	40	36	http://www.eurjchem.com/	http://www.eurjchem.com/	PROPN
eurjchem-2350	40	37	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.14.1.30-38.2350&domain=pdf&date_stamp=2023-03-31	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.14.1.30-38.2350&domain=pdf&date_stamp=2023-03-31	PROPN
eurjchem-2350	40	38	kumar	kumar	PROPN
eurjchem-2350	40	39	et	et	PROPN
eurjchem-2350	40	40	al	al	PROPN
eurjchem-2350	40	41	.	.	PUNCT
eurjchem-2350	40	42	/	/	SYM
eurjchem-2350	40	43	european	european	PROPN
eurjchem-2350	40	44	journal	journal	PROPN
eurjchem-2350	40	45	of	of	ADP
eurjchem-2350	40	46	chemistry	chemistry	NOUN
eurjchem-2350	40	47	14	14	NUM
eurjchem-2350	40	48	(	(	PUNCT
eurjchem-2350	40	49	1	1	NUM
eurjchem-2350	40	50	)	)	PUNCT
eurjchem-2350	40	51	(	(	PUNCT
eurjchem-2350	40	52	2023	2023	NUM
eurjchem-2350	40	53	)	)	PUNCT
eurjchem-2350	40	54	30	30	NUM
eurjchem-2350	40	55	-	-	SYM
eurjchem-2350	40	56	38	38	NUM
eurjchem-2350	40	57	31	31	NUM
eurjchem-2350	40	58	2023	2023	NUM
eurjchem-2350	40	59	–	–	PUNCT
eurjchem-2350	40	60	european	european	ADJ
eurjchem-2350	40	61	journal	journal	NOUN
eurjchem-2350	40	62	of	of	ADP
eurjchem-2350	40	63	chemistry	chemistry	NOUN
eurjchem-2350	40	64	–	–	PUNCT
eurjchem-2350	40	65	cc	cc	NOUN
eurjchem-2350	40	66	by	by	ADP
eurjchem-2350	40	67	nc	nc	PROPN
eurjchem-2350	40	68	–	–	PUNCT
eurjchem-2350	40	69	doi	doi	PROPN
eurjchem-2350	40	70	:	:	PUNCT
eurjchem-2350	40	71	10.5155	10.5155	NUM
eurjchem-2350	40	72	/	/	SYM
eurjchem-2350	40	73	eurjchem.14.1.30	eurjchem.14.1.30	PROPN
eurjchem-2350	40	74	-	-	PUNCT
eurjchem-2350	40	75	38.2350	38.2350	NUM
eurjchem-2350	40	76	figure	figure	NOUN
eurjchem-2350	40	77	1	1	NUM
eurjchem-2350	40	78	.	.	PUNCT
eurjchem-2350	41	1	the	the	DET
eurjchem-2350	41	2	scheme	scheme	NOUN
eurjchem-2350	41	3	portrays	portray	VERB
eurjchem-2350	41	4	the	the	DET
eurjchem-2350	41	5	detection	detection	NOUN
eurjchem-2350	41	6	of	of	ADP
eurjchem-2350	41	7	active	active	ADJ
eurjchem-2350	41	8	quinoline	quinoline	NOUN
eurjchem-2350	41	9	analogues	analogue	NOUN
eurjchem-2350	41	10	against	against	ADP
eurjchem-2350	41	11	five	five	NUM
eurjchem-2350	41	12	specific	specific	ADJ
eurjchem-2350	41	13	main	main	ADJ
eurjchem-2350	41	14	proteases	protease	NOUN
eurjchem-2350	41	15	of	of	ADP
eurjchem-2350	41	16	sars	sar	NOUN
eurjchem-2350	41	17	-	-	PUNCT
eurjchem-2350	41	18	cov-2	cov-2	NOUN
eurjchem-2350	41	19	.	.	PUNCT
eurjchem-2350	41	20	mpro	mpro	ADJ
eurjchem-2350	41	21	structures	structure	NOUN
eurjchem-2350	41	22	were	be	AUX
eurjchem-2350	41	23	obtained	obtain	VERB
eurjchem-2350	41	24	from	from	ADP
eurjchem-2350	41	25	the	the	DET
eurjchem-2350	41	26	rcsb	rcsb	ADJ
eurjchem-2350	41	27	protein	protein	NOUN
eurjchem-2350	41	28	data	data	PROPN
eurjchem-2350	41	29	bank	bank	PROPN
eurjchem-2350	41	30	.	.	PUNCT
eurjchem-2350	42	1	figure	figure	NOUN
eurjchem-2350	42	2	2	2	NUM
eurjchem-2350	42	3	.	.	PUNCT
eurjchem-2350	43	1	schematic	schematic	ADJ
eurjchem-2350	43	2	representation	representation	NOUN
eurjchem-2350	43	3	of	of	ADP
eurjchem-2350	43	4	the	the	DET
eurjchem-2350	43	5	broad	broad	ADJ
eurjchem-2350	43	6	structural	structural	ADJ
eurjchem-2350	43	7	characteristics	characteristic	NOUN
eurjchem-2350	43	8	of	of	ADP
eurjchem-2350	43	9	ten	ten	NUM
eurjchem-2350	43	10	quinoline	quinoline	ADJ
eurjchem-2350	43	11	derivatives	derivative	NOUN
eurjchem-2350	43	12	[	[	X
eurjchem-2350	43	13	29	29	NUM
eurjchem-2350	43	14	]	]	PUNCT
eurjchem-2350	43	15	.	.	PUNCT
eurjchem-2350	44	1	advantages	advantage	NOUN
eurjchem-2350	44	2	,	,	PUNCT
eurjchem-2350	44	3	there	there	PRON
eurjchem-2350	44	4	is	be	VERB
eurjchem-2350	44	5	still	still	ADV
eurjchem-2350	44	6	a	a	DET
eurjchem-2350	44	7	strong	strong	ADJ
eurjchem-2350	44	8	beneficial	beneficial	ADJ
eurjchem-2350	44	9	impact	impact	NOUN
eurjchem-2350	44	10	to	to	PART
eurjchem-2350	44	11	be	be	AUX
eurjchem-2350	44	12	shown	show	VERB
eurjchem-2350	44	13	[	[	PUNCT
eurjchem-2350	44	14	22	22	NUM
eurjchem-2350	44	15	]	]	PUNCT
eurjchem-2350	44	16	.	.	PUNCT
eurjchem-2350	45	1	therefore	therefore	ADV
eurjchem-2350	45	2	,	,	PUNCT
eurjchem-2350	45	3	several	several	ADJ
eurjchem-2350	45	4	clinical	clinical	ADJ
eurjchem-2350	45	5	research	research	NOUN
eurjchem-2350	45	6	registers	register	NOUN
eurjchem-2350	45	7	for	for	ADP
eurjchem-2350	45	8	the	the	DET
eurjchem-2350	45	9	use	use	NOUN
eurjchem-2350	45	10	of	of	ADP
eurjchem-2350	45	11	hcq	hcq	NOUN
eurjchem-2350	45	12	in	in	ADP
eurjchem-2350	45	13	the	the	DET
eurjchem-2350	45	14	treatment	treatment	NOUN
eurjchem-2350	45	15	of	of	ADP
eurjchem-2350	45	16	covid-19	covid-19	PROPN
eurjchem-2350	45	17	have	have	AUX
eurjchem-2350	45	18	been	be	AUX
eurjchem-2350	45	19	listed	list	VERB
eurjchem-2350	45	20	in	in	ADP
eurjchem-2350	45	21	the	the	DET
eurjchem-2350	45	22	chinese	chinese	ADJ
eurjchem-2350	45	23	clinical	clinical	ADJ
eurjchem-2350	45	24	trial	trial	NOUN
eurjchem-2350	45	25	registry	registry	NOUN
eurjchem-2350	45	26	(	(	PUNCT
eurjchem-2350	45	27	http://www.chictr.org.cn	http://www.chictr.org.cn	X
eurjchem-2350	45	28	)	)	PUNCT
eurjchem-2350	46	1	[	[	X
eurjchem-2350	46	2	23	23	NUM
eurjchem-2350	46	3	]	]	PUNCT
eurjchem-2350	46	4	.	.	PUNCT
eurjchem-2350	47	1	in	in	ADP
eurjchem-2350	47	2	addition	addition	NOUN
eurjchem-2350	47	3	,	,	PUNCT
eurjchem-2350	47	4	there	there	PRON
eurjchem-2350	47	5	is	be	VERB
eurjchem-2350	47	6	still	still	ADV
eurjchem-2350	47	7	a	a	DET
eurjchem-2350	47	8	lack	lack	NOUN
eurjchem-2350	47	9	of	of	ADP
eurjchem-2350	47	10	clinical	clinical	ADJ
eurjchem-2350	47	11	evidence	evidence	NOUN
eurjchem-2350	47	12	to	to	PART
eurjchem-2350	47	13	show	show	VERB
eurjchem-2350	47	14	that	that	SCONJ
eurjchem-2350	47	15	cq	cq	PROPN
eurjchem-2350	47	16	is	be	AUX
eurjchem-2350	47	17	as	as	ADV
eurjchem-2350	47	18	effective	effective	ADJ
eurjchem-2350	47	19	as	as	ADP
eurjchem-2350	47	20	hcq	hcq	NOUN
eurjchem-2350	47	21	for	for	ADP
eurjchem-2350	47	22	the	the	DET
eurjchem-2350	47	23	treatment	treatment	NOUN
eurjchem-2350	47	24	of	of	ADP
eurjchem-2350	47	25	covid-19	covid-19	PROPN
eurjchem-2350	47	26	infection	infection	NOUN
eurjchem-2350	47	27	[	[	X
eurjchem-2350	47	28	24,25	24,25	NUM
eurjchem-2350	47	29	]	]	PUNCT
eurjchem-2350	47	30	.	.	PUNCT
eurjchem-2350	48	1	therefore	therefore	ADV
eurjchem-2350	48	2	,	,	PUNCT
eurjchem-2350	48	3	the	the	DET
eurjchem-2350	48	4	widely	widely	ADV
eurjchem-2350	48	5	used	use	VERB
eurjchem-2350	48	6	antimalarial	antimalarial	NOUN
eurjchem-2350	48	7	cq	cq	PROPN
eurjchem-2350	48	8	and	and	CCONJ
eurjchem-2350	48	9	,	,	PUNCT
eurjchem-2350	48	10	more	more	ADV
eurjchem-2350	48	11	importantly	importantly	ADV
eurjchem-2350	48	12	,	,	PUNCT
eurjchem-2350	48	13	hcq	hcq	PROPN
eurjchem-2350	48	14	have	have	AUX
eurjchem-2350	48	15	been	be	AUX
eurjchem-2350	48	16	portrayed	portray	VERB
eurjchem-2350	48	17	to	to	PART
eurjchem-2350	48	18	deal	deal	VERB
eurjchem-2350	48	19	with	with	ADP
eurjchem-2350	48	20	covid-19	covid-19	PROPN
eurjchem-2350	48	21	threats	threat	NOUN
eurjchem-2350	48	22	in	in	ADP
eurjchem-2350	48	23	travelers	traveler	NOUN
eurjchem-2350	48	24	who	who	PRON
eurjchem-2350	48	25	commute	commute	VERB
eurjchem-2350	48	26	between	between	ADP
eurjchem-2350	48	27	endemic	endemic	ADJ
eurjchem-2350	48	28	and	and	CCONJ
eurjchem-2350	48	29	nonendemic	nonendemic	ADJ
eurjchem-2350	48	30	regions	region	NOUN
eurjchem-2350	48	31	[	[	X
eurjchem-2350	48	32	26	26	NUM
eurjchem-2350	48	33	]	]	PUNCT
eurjchem-2350	48	34	.	.	PUNCT
eurjchem-2350	49	1	keeping	keep	VERB
eurjchem-2350	49	2	in	in	ADP
eurjchem-2350	49	3	view	view	NOUN
eurjchem-2350	49	4	of	of	ADP
eurjchem-2350	49	5	the	the	DET
eurjchem-2350	49	6	lack	lack	NOUN
eurjchem-2350	49	7	of	of	ADP
eurjchem-2350	49	8	proper	proper	ADJ
eurjchem-2350	49	9	treatment	treatment	NOUN
eurjchem-2350	49	10	,	,	PUNCT
eurjchem-2350	49	11	it	it	PRON
eurjchem-2350	49	12	is	be	AUX
eurjchem-2350	49	13	essential	essential	ADJ
eurjchem-2350	49	14	to	to	PART
eurjchem-2350	49	15	look	look	VERB
eurjchem-2350	49	16	for	for	ADP
eurjchem-2350	49	17	specific	specific	ADJ
eurjchem-2350	49	18	potential	potential	ADJ
eurjchem-2350	49	19	drugs	drug	NOUN
eurjchem-2350	49	20	against	against	ADP
eurjchem-2350	49	21	covid-19	covid-19	PROPN
eurjchem-2350	49	22	infection	infection	NOUN
eurjchem-2350	49	23	and	and	CCONJ
eurjchem-2350	49	24	the	the	DET
eurjchem-2350	49	25	biological	biological	ADJ
eurjchem-2350	49	26	efficacy	efficacy	NOUN
eurjchem-2350	49	27	of	of	ADP
eurjchem-2350	49	28	quinoline	quinoline	NOUN
eurjchem-2350	49	29	ring	ring	NOUN
eurjchem-2350	49	30	system	system	NOUN
eurjchem-2350	49	31	being	be	AUX
eurjchem-2350	49	32	effective	effective	ADJ
eurjchem-2350	49	33	against	against	ADP
eurjchem-2350	49	34	covid-19	covid-19	PROPN
eurjchem-2350	49	35	(	(	PUNCT
eurjchem-2350	49	36	cq	cq	NOUN
eurjchem-2350	49	37	and	and	CCONJ
eurjchem-2350	49	38	hcq	hcq	NOUN
eurjchem-2350	49	39	)	)	PUNCT
eurjchem-2350	49	40	.	.	PUNCT
eurjchem-2350	50	1	it	it	PRON
eurjchem-2350	50	2	has	have	AUX
eurjchem-2350	50	3	been	be	AUX
eurjchem-2350	50	4	shown	show	VERB
eurjchem-2350	50	5	that	that	SCONJ
eurjchem-2350	50	6	main	main	ADJ
eurjchem-2350	50	7	protease	protease	NOUN
eurjchem-2350	50	8	is	be	AUX
eurjchem-2350	50	9	a	a	DET
eurjchem-2350	50	10	key	key	ADJ
eurjchem-2350	50	11	enzyme	enzyme	NOUN
eurjchem-2350	50	12	of	of	ADP
eurjchem-2350	50	13	corona	corona	NOUN
eurjchem-2350	50	14	viruses	virus	NOUN
eurjchem-2350	50	15	,	,	PUNCT
eurjchem-2350	50	16	which	which	PRON
eurjchem-2350	50	17	plays	play	VERB
eurjchem-2350	50	18	an	an	DET
eurjchem-2350	50	19	essential	essential	ADJ
eurjchem-2350	50	20	role	role	NOUN
eurjchem-2350	50	21	in	in	ADP
eurjchem-2350	50	22	several	several	ADJ
eurjchem-2350	50	23	vital	vital	ADJ
eurjchem-2350	50	24	cell	cell	NOUN
eurjchem-2350	50	25	processes	process	NOUN
eurjchem-2350	50	26	to	to	PART
eurjchem-2350	50	27	build	build	VERB
eurjchem-2350	50	28	it	it	PRON
eurjchem-2350	50	29	as	as	ADP
eurjchem-2350	50	30	an	an	DET
eurjchem-2350	50	31	attractive	attractive	ADJ
eurjchem-2350	50	32	drug	drug	NOUN
eurjchem-2350	50	33	target	target	NOUN
eurjchem-2350	50	34	for	for	ADP
eurjchem-2350	50	35	covid-19	covid-19	PROPN
eurjchem-2350	51	1	[	[	X
eurjchem-2350	51	2	27	27	NUM
eurjchem-2350	51	3	]	]	PUNCT
eurjchem-2350	51	4	.	.	PUNCT
eurjchem-2350	52	1	in	in	ADP
eurjchem-2350	52	2	this	this	DET
eurjchem-2350	52	3	direction	direction	NOUN
eurjchem-2350	52	4	,	,	PUNCT
eurjchem-2350	52	5	a	a	DET
eurjchem-2350	52	6	series	series	NOUN
eurjchem-2350	52	7	of	of	ADP
eurjchem-2350	52	8	ten	ten	NUM
eurjchem-2350	52	9	quinoline	quinoline	NOUN
eurjchem-2350	52	10	analogues	analogue	NOUN
eurjchem-2350	52	11	were	be	AUX
eurjchem-2350	52	12	chosen	choose	VERB
eurjchem-2350	52	13	to	to	PART
eurjchem-2350	52	14	study	study	VERB
eurjchem-2350	52	15	their	their	PRON
eurjchem-2350	52	16	adme	adme	NOUN
eurjchem-2350	52	17	properties	property	NOUN
eurjchem-2350	52	18	using	use	VERB
eurjchem-2350	52	19	schrodinger	schrodinger	PROPN
eurjchem-2350	52	20	qikprop	qikprop	PROPN
eurjchem-2350	52	21	software	software	PROPN
eurjchem-2350	52	22	and	and	CCONJ
eurjchem-2350	52	23	to	to	PART
eurjchem-2350	52	24	compare	compare	VERB
eurjchem-2350	52	25	their	their	PRON
eurjchem-2350	52	26	drug	drug	NOUN
eurjchem-2350	52	27	-	-	PUNCT
eurjchem-2350	52	28	likeness	likeness	NOUN
eurjchem-2350	52	29	properties	property	NOUN
eurjchem-2350	52	30	and	and	CCONJ
eurjchem-2350	52	31	medicinal	medicinal	ADJ
eurjchem-2350	52	32	chemistry	chemistry	NOUN
eurjchem-2350	52	33	friendliness	friendliness	VERB
eurjchem-2350	52	34	with	with	ADP
eurjchem-2350	52	35	known	know	VERB
eurjchem-2350	52	36	drug	drug	NOUN
eurjchem-2350	52	37	molecules	molecule	NOUN
eurjchem-2350	52	38	.	.	PUNCT
eurjchem-2350	53	1	recently	recently	ADV
eurjchem-2350	53	2	,	,	PUNCT
eurjchem-2350	53	3	we	we	PRON
eurjchem-2350	53	4	have	have	AUX
eurjchem-2350	53	5	shown	show	VERB
eurjchem-2350	53	6	that	that	SCONJ
eurjchem-2350	53	7	some	some	PRON
eurjchem-2350	53	8	of	of	ADP
eurjchem-2350	53	9	these	these	DET
eurjchem-2350	53	10	derivatives	derivative	NOUN
eurjchem-2350	53	11	are	be	AUX
eurjchem-2350	53	12	highly	highly	ADV
eurjchem-2350	53	13	effective	effective	ADJ
eurjchem-2350	53	14	in	in	ADP
eurjchem-2350	53	15	inhibiting	inhibit	VERB
eurjchem-2350	53	16	breast	breast	NOUN
eurjchem-2350	53	17	cancer	cancer	NOUN
eurjchem-2350	53	18	and	and	CCONJ
eurjchem-2350	53	19	colorectal	colorectal	ADJ
eurjchem-2350	53	20	cancer	cancer	NOUN
eurjchem-2350	53	21	cells	cell	NOUN
eurjchem-2350	53	22	in	in	ADP
eurjchem-2350	53	23	vitro	vitro	X
eurjchem-2350	54	1	[	[	X
eurjchem-2350	54	2	28	28	NUM
eurjchem-2350	54	3	]	]	PUNCT
eurjchem-2350	54	4	.	.	PUNCT
eurjchem-2350	55	1	in	in	ADP
eurjchem-2350	55	2	this	this	DET
eurjchem-2350	55	3	study	study	NOUN
eurjchem-2350	55	4	,	,	PUNCT
eurjchem-2350	55	5	we	we	PRON
eurjchem-2350	55	6	attempted	attempt	VERB
eurjchem-2350	55	7	to	to	PART
eurjchem-2350	55	8	determine	determine	VERB
eurjchem-2350	55	9	the	the	DET
eurjchem-2350	55	10	efficacy	efficacy	NOUN
eurjchem-2350	55	11	of	of	ADP
eurjchem-2350	55	12	these	these	DET
eurjchem-2350	55	13	quinoline	quinoline	NOUN
eurjchem-2350	55	14	analogues	analogue	NOUN
eurjchem-2350	55	15	against	against	ADP
eurjchem-2350	55	16	five	five	NUM
eurjchem-2350	55	17	specific	specific	ADJ
eurjchem-2350	55	18	main	main	ADJ
eurjchem-2350	55	19	proteases	protease	NOUN
eurjchem-2350	55	20	of	of	ADP
eurjchem-2350	55	21	sars	sar	NOUN
eurjchem-2350	55	22	-	-	PUNCT
eurjchem-2350	55	23	cov-2	cov-2	PART
eurjchem-2350	55	24	(	(	PUNCT
eurjchem-2350	55	25	figure	figure	NOUN
eurjchem-2350	55	26	1	1	NUM
eurjchem-2350	55	27	)	)	PUNCT
eurjchem-2350	55	28	.	.	PUNCT
eurjchem-2350	56	1	the	the	DET
eurjchem-2350	56	2	binding	bind	VERB
eurjchem-2350	56	3	affinity	affinity	NOUN
eurjchem-2350	56	4	interactions	interaction	NOUN
eurjchem-2350	56	5	of	of	ADP
eurjchem-2350	56	6	these	these	DET
eurjchem-2350	56	7	quinolines	quinoline	NOUN
eurjchem-2350	56	8	were	be	AUX
eurjchem-2350	56	9	compared	compare	VERB
eurjchem-2350	56	10	with	with	ADP
eurjchem-2350	56	11	rdv	rdv	NOUN
eurjchem-2350	56	12	and	and	CCONJ
eurjchem-2350	56	13	hcq	hcq	NOUN
eurjchem-2350	56	14	against	against	ADP
eurjchem-2350	56	15	sars	sar	NOUN
eurjchem-2350	56	16	-	-	PUNCT
eurjchem-2350	56	17	cov-2	cov-2	NOUN
eurjchem-2350	56	18	proteases	protease	NOUN
eurjchem-2350	56	19	to	to	PART
eurjchem-2350	56	20	evaluate	evaluate	VERB
eurjchem-2350	56	21	their	their	PRON
eurjchem-2350	56	22	efficacy	efficacy	NOUN
eurjchem-2350	56	23	.	.	PUNCT
eurjchem-2350	57	1	the	the	DET
eurjchem-2350	57	2	structures	structure	NOUN
eurjchem-2350	57	3	of	of	ADP
eurjchem-2350	57	4	the	the	DET
eurjchem-2350	57	5	main	main	ADJ
eurjchem-2350	57	6	proteases	protease	NOUN
eurjchem-2350	57	7	of	of	ADP
eurjchem-2350	57	8	the	the	DET
eurjchem-2350	57	9	sars	sar	NOUN
eurjchem-2350	57	10	-	-	PUNCT
eurjchem-2350	57	11	cov-2	cov-2	NOUN
eurjchem-2350	57	12	virus	virus	NOUN
eurjchem-2350	57	13	(	(	PUNCT
eurjchem-2350	57	14	pdb	pdb	PROPN
eurjchem-2350	57	15	i	i	PROPN
eurjchem-2350	57	16	d	d	PROPN
eurjchem-2350	57	17	:	:	PUNCT
eurjchem-2350	57	18	6lu7	6lu7	NUM
eurjchem-2350	57	19	,	,	PUNCT
eurjchem-2350	57	20	6w63	6w63	NUM
eurjchem-2350	57	21	,	,	PUNCT
eurjchem-2350	57	22	6m03	6m03	NOUN
eurjchem-2350	57	23	,	,	PUNCT
eurjchem-2350	57	24	6y84	6y84	NOUN
eurjchem-2350	57	25	and	and	CCONJ
eurjchem-2350	57	26	6yb7	6yb7	NUM
eurjchem-2350	57	27	)	)	PUNCT
eurjchem-2350	57	28	were	be	AUX
eurjchem-2350	57	29	used	use	VERB
eurjchem-2350	57	30	to	to	PART
eurjchem-2350	57	31	generate	generate	VERB
eurjchem-2350	57	32	receptor	receptor	NOUN
eurjchem-2350	57	33	grids	grid	NOUN
eurjchem-2350	57	34	for	for	ADP
eurjchem-2350	57	35	docking	docking	NOUN
eurjchem-2350	57	36	and	and	CCONJ
eurjchem-2350	57	37	to	to	PART
eurjchem-2350	57	38	determine	determine	VERB
eurjchem-2350	57	39	the	the	DET
eurjchem-2350	57	40	center	center	NOUN
eurjchem-2350	57	41	of	of	ADP
eurjchem-2350	57	42	the	the	DET
eurjchem-2350	57	43	active	active	ADJ
eurjchem-2350	57	44	site	site	NOUN
eurjchem-2350	57	45	for	for	ADP
eurjchem-2350	57	46	the	the	DET
eurjchem-2350	57	47	binding	bind	VERB
eurjchem-2350	57	48	efficacy	efficacy	NOUN
eurjchem-2350	57	49	comparison	comparison	NOUN
eurjchem-2350	57	50	between	between	ADP
eurjchem-2350	57	51	the	the	DET
eurjchem-2350	57	52	quinolines	quinoline	NOUN
eurjchem-2350	57	53	with	with	ADP
eurjchem-2350	57	54	that	that	PRON
eurjchem-2350	57	55	of	of	ADP
eurjchem-2350	57	56	rdv	rdv	NOUN
eurjchem-2350	57	57	and	and	CCONJ
eurjchem-2350	57	58	hcq	hcq	NOUN
eurjchem-2350	57	59	.	.	PUNCT
eurjchem-2350	58	1	these	these	DET
eurjchem-2350	58	2	studies	study	NOUN
eurjchem-2350	58	3	have	have	AUX
eurjchem-2350	58	4	shown	show	VERB
eurjchem-2350	58	5	that	that	SCONJ
eurjchem-2350	58	6	,	,	PUNCT
eurjchem-2350	58	7	among	among	ADP
eurjchem-2350	58	8	the	the	DET
eurjchem-2350	58	9	ten	ten	NUM
eurjchem-2350	58	10	quinolines	quinoline	NOUN
eurjchem-2350	58	11	,	,	PUNCT
eurjchem-2350	58	12	molecule	molecule	NOUN
eurjchem-2350	58	13	q9	q9	PROPN
eurjchem-2350	58	14	was	be	AUX
eurjchem-2350	58	15	found	find	VERB
eurjchem-2350	58	16	to	to	PART
eurjchem-2350	58	17	be	be	AUX
eurjchem-2350	58	18	the	the	DET
eurjchem-2350	58	19	most	most	ADV
eurjchem-2350	58	20	potent	potent	ADJ
eurjchem-2350	58	21	inhibitor	inhibitor	NOUN
eurjchem-2350	58	22	of	of	ADP
eurjchem-2350	58	23	all	all	DET
eurjchem-2350	58	24	these	these	DET
eurjchem-2350	58	25	main	main	ADJ
eurjchem-2350	58	26	proteases	protease	NOUN
eurjchem-2350	58	27	.	.	PUNCT
eurjchem-2350	59	1	furthermore	furthermore	ADV
eurjchem-2350	59	2	,	,	PUNCT
eurjchem-2350	59	3	the	the	DET
eurjchem-2350	59	4	stability	stability	NOUN
eurjchem-2350	59	5	of	of	ADP
eurjchem-2350	59	6	q9	q9	PROPN
eurjchem-2350	59	7	inside	inside	ADP
eurjchem-2350	59	8	the	the	DET
eurjchem-2350	59	9	active	active	ADJ
eurjchem-2350	59	10	site	site	NOUN
eurjchem-2350	59	11	of	of	ADP
eurjchem-2350	59	12	mpro	mpro	ADJ
eurjchem-2350	59	13	(	(	PUNCT
eurjchem-2350	59	14	pdb	pdb	NOUN
eurjchem-2350	59	15	6lu7	6lu7	NUM
eurjchem-2350	59	16	)	)	PUNCT
eurjchem-2350	59	17	was	be	AUX
eurjchem-2350	59	18	further	far	ADV
eurjchem-2350	59	19	investigated	investigate	VERB
eurjchem-2350	59	20	by	by	ADP
eurjchem-2350	59	21	molecular	molecular	ADJ
eurjchem-2350	59	22	dynamics	dynamic	NOUN
eurjchem-2350	59	23	simulation	simulation	NOUN
eurjchem-2350	59	24	analysis	analysis	NOUN
eurjchem-2350	59	25	.	.	PUNCT
eurjchem-2350	60	1	2	2	X
eurjchem-2350	60	2	.	.	X
eurjchem-2350	60	3	experimental	experimental	ADJ
eurjchem-2350	60	4	2.1	2.1	NUM
eurjchem-2350	60	5	.	.	PUNCT
eurjchem-2350	61	1	quinolines	quinoline	NOUN
eurjchem-2350	61	2	as	as	ADP
eurjchem-2350	61	3	potential	potential	ADJ
eurjchem-2350	61	4	drug	drug	NOUN
eurjchem-2350	61	5	molecules	molecule	NOUN
eurjchem-2350	61	6	we	we	PRON
eurjchem-2350	61	7	have	have	AUX
eurjchem-2350	61	8	used	use	VERB
eurjchem-2350	61	9	ten	ten	NUM
eurjchem-2350	61	10	quinoline	quinoline	NOUN
eurjchem-2350	61	11	analogs	analog	NOUN
eurjchem-2350	61	12	that	that	PRON
eurjchem-2350	61	13	are	be	AUX
eurjchem-2350	61	14	available	available	ADJ
eurjchem-2350	61	15	in	in	ADP
eurjchem-2350	61	16	our	our	PRON
eurjchem-2350	61	17	small	small	ADJ
eurjchem-2350	61	18	molecules	molecule	NOUN
eurjchem-2350	61	19	library	library	NOUN
eurjchem-2350	61	20	to	to	PART
eurjchem-2350	61	21	carry	carry	VERB
eurjchem-2350	61	22	out	out	ADP
eurjchem-2350	61	23	the	the	DET
eurjchem-2350	61	24	present	present	ADJ
eurjchem-2350	61	25	investigation	investigation	NOUN
eurjchem-2350	61	26	,	,	PUNCT
eurjchem-2350	61	27	which	which	PRON
eurjchem-2350	61	28	is	be	AUX
eurjchem-2350	61	29	depicted	depict	VERB
eurjchem-2350	61	30	in	in	ADP
eurjchem-2350	61	31	figure	figure	NOUN
eurjchem-2350	61	32	2	2	NUM
eurjchem-2350	61	33	.	.	PUNCT
eurjchem-2350	62	1	these	these	DET
eurjchem-2350	62	2	molecules	molecule	NOUN
eurjchem-2350	62	3	were	be	AUX
eurjchem-2350	62	4	synthesized	synthesize	VERB
eurjchem-2350	62	5	in	in	ADP
eurjchem-2350	62	6	our	our	PRON
eurjchem-2350	62	7	laboratory	laboratory	NOUN
eurjchem-2350	62	8	as	as	SCONJ
eurjchem-2350	62	9	previously	previously	ADV
eurjchem-2350	62	10	published	publish	VERB
eurjchem-2350	62	11	[	[	PUNCT
eurjchem-2350	62	12	29	29	NUM
eurjchem-2350	62	13	]	]	PUNCT
eurjchem-2350	62	14	.	.	PUNCT
eurjchem-2350	63	1	2.2	2.2	NUM
eurjchem-2350	63	2	.	.	PUNCT
eurjchem-2350	63	3	ligand	ligand	ADJ
eurjchem-2350	63	4	preparation	preparation	NOUN
eurjchem-2350	63	5	and	and	CCONJ
eurjchem-2350	63	6	analysis	analysis	NOUN
eurjchem-2350	63	7	for	for	ADP
eurjchem-2350	63	8	in	in	ADP
eurjchem-2350	63	9	silico	silico	NOUN
eurjchem-2350	63	10	analysis	analysis	NOUN
eurjchem-2350	63	11	,	,	PUNCT
eurjchem-2350	63	12	the	the	DET
eurjchem-2350	63	13	structures	structure	NOUN
eurjchem-2350	63	14	of	of	ADP
eurjchem-2350	63	15	the	the	DET
eurjchem-2350	63	16	quinoline	quinoline	NOUN
eurjchem-2350	63	17	molecules	molecule	NOUN
eurjchem-2350	63	18	were	be	AUX
eurjchem-2350	63	19	drawn	draw	VERB
eurjchem-2350	63	20	using	use	VERB
eurjchem-2350	63	21	the	the	DET
eurjchem-2350	63	22	marvin	marvin	PROPN
eurjchem-2350	63	23	sketch	sketch	PROPN
eurjchem-2350	63	24	tool	tool	PROPN
eurjchem-2350	63	25	and	and	CCONJ
eurjchem-2350	63	26	the	the	DET
eurjchem-2350	63	27	smiles	smile	NOUN
eurjchem-2350	63	28	format	format	NOUN
eurjchem-2350	63	29	was	be	AUX
eurjchem-2350	63	30	extracted	extract	VERB
eurjchem-2350	63	31	for	for	ADP
eurjchem-2350	63	32	further	further	ADJ
eurjchem-2350	63	33	prediction	prediction	NOUN
eurjchem-2350	64	1	[	[	X
eurjchem-2350	64	2	30	30	NUM
eurjchem-2350	64	3	]	]	PUNCT
eurjchem-2350	64	4	.	.	PUNCT
eurjchem-2350	65	1	http://www.chictr.org.cn/	http://www.chictr.org.cn/	PROPN
eurjchem-2350	65	2	32	32	NUM
eurjchem-2350	65	3	kumar	kumar	PROPN
eurjchem-2350	65	4	et	et	PROPN
eurjchem-2350	65	5	al	al	PROPN
eurjchem-2350	65	6	.	.	PUNCT
eurjchem-2350	65	7	/	/	SYM
eurjchem-2350	65	8	european	european	PROPN
eurjchem-2350	65	9	journal	journal	PROPN
eurjchem-2350	65	10	of	of	ADP
eurjchem-2350	65	11	chemistry	chemistry	NOUN
eurjchem-2350	65	12	14	14	NUM
eurjchem-2350	65	13	(	(	PUNCT
eurjchem-2350	65	14	1	1	NUM
eurjchem-2350	65	15	)	)	PUNCT
eurjchem-2350	65	16	(	(	PUNCT
eurjchem-2350	65	17	2023	2023	NUM
eurjchem-2350	65	18	)	)	PUNCT
eurjchem-2350	65	19	30	30	NUM
eurjchem-2350	65	20	-	-	SYM
eurjchem-2350	65	21	38	38	NUM
eurjchem-2350	65	22	2023	2023	NUM
eurjchem-2350	65	23	–	–	PUNCT
eurjchem-2350	65	24	european	european	ADJ
eurjchem-2350	65	25	journal	journal	NOUN
eurjchem-2350	65	26	of	of	ADP
eurjchem-2350	65	27	chemistry	chemistry	NOUN
eurjchem-2350	65	28	–	–	PUNCT
eurjchem-2350	65	29	cc	cc	NOUN
eurjchem-2350	65	30	by	by	ADP
eurjchem-2350	65	31	nc	nc	PROPN
eurjchem-2350	65	32	–	–	PUNCT
eurjchem-2350	65	33	doi	doi	PROPN
eurjchem-2350	65	34	:	:	PUNCT
eurjchem-2350	65	35	10.5155	10.5155	NUM
eurjchem-2350	65	36	/	/	SYM
eurjchem-2350	65	37	eurjchem.14.1.30	eurjchem.14.1.30	PROPN
eurjchem-2350	65	38	-	-	PUNCT
eurjchem-2350	65	39	38.2350	38.2350	NUM
eurjchem-2350	65	40	table	table	NOUN
eurjchem-2350	65	41	1	1	NUM
eurjchem-2350	65	42	.	.	PUNCT
eurjchem-2350	65	43	qikprop	qikprop	NOUN
eurjchem-2350	65	44	3.4	3.4	NUM
eurjchem-2350	65	45	prediction	prediction	NOUN
eurjchem-2350	65	46	of	of	ADP
eurjchem-2350	65	47	admet	admet	ADJ
eurjchem-2350	65	48	values	value	NOUN
eurjchem-2350	65	49	of	of	ADP
eurjchem-2350	65	50	quinoline	quinoline	NOUN
eurjchem-2350	65	51	analogs	analog	NOUN
eurjchem-2350	65	52	.	.	PUNCT
eurjchem-2350	66	1	#	#	NOUN
eurjchem-2350	66	2	of	of	ADP
eurjchem-2350	66	3	stars	stars	PROPN
eurjchem-2350	66	4	q1	q1	PROPN
eurjchem-2350	66	5	q2	q2	PROPN
eurjchem-2350	66	6	q3	q3	PROPN
eurjchem-2350	66	7	q4	q4	PROPN
eurjchem-2350	66	8	q5	q5	PROPN
eurjchem-2350	66	9	q6	q6	PROPN
eurjchem-2350	66	10	q7	q7	PROPN
eurjchem-2350	66	11	q8	q8	PROPN
eurjchem-2350	66	12	q9	q9	PROPN
eurjchem-2350	66	13	q10	q10	PROPN
eurjchem-2350	66	14	recommended	recommend	VERB
eurjchem-2350	66	15	value	value	NOUN
eurjchem-2350	66	16	0	0	NUM
eurjchem-2350	66	17	0	0	NUM
eurjchem-2350	66	18	0	0	NUM
eurjchem-2350	66	19	0	0	NUM
eurjchem-2350	66	20	0	0	NUM
eurjchem-2350	66	21	0	0	NUM
eurjchem-2350	66	22	0	0	NUM
eurjchem-2350	66	23	0	0	NUM
eurjchem-2350	66	24	0	0	NUM
eurjchem-2350	66	25	0	0	NUM
eurjchem-2350	66	26	0	0	NUM
eurjchem-2350	66	27	-	-	SYM
eurjchem-2350	66	28	5	5	NUM
eurjchem-2350	66	29	cns	cns	NOUN
eurjchem-2350	66	30	1	1	NUM
eurjchem-2350	66	31	1	1	NUM
eurjchem-2350	66	32	1	1	NUM
eurjchem-2350	66	33	1	1	NUM
eurjchem-2350	66	34	1	1	NUM
eurjchem-2350	66	35	1	1	NUM
eurjchem-2350	66	36	1	1	NUM
eurjchem-2350	66	37	1	1	NUM
eurjchem-2350	66	38	2	2	NUM
eurjchem-2350	66	39	1	1	NUM
eurjchem-2350	66	40	–	–	SYM
eurjchem-2350	66	41	2	2	NUM
eurjchem-2350	66	42	(	(	PUNCT
eurjchem-2350	66	43	inactive	inactive	ADJ
eurjchem-2350	66	44	)	)	PUNCT
eurjchem-2350	66	45	,	,	PUNCT
eurjchem-2350	66	46	+2	+2	PROPN
eurjchem-2350	66	47	(	(	PUNCT
eurjchem-2350	66	48	active	active	ADJ
eurjchem-2350	66	49	)	)	PUNCT
eurjchem-2350	66	50	mw	mw	VERB
eurjchem-2350	66	51	290.750	290.750	NUM
eurjchem-2350	66	52	318.805	318.805	NUM
eurjchem-2350	66	53	332.832	332.832	NUM
eurjchem-2350	66	54	346.859	346.859	NUM
eurjchem-2350	66	55	334.805	334.805	NUM
eurjchem-2350	66	56	369.648	369.648	NUM
eurjchem-2350	66	57	397.701	397.701	NUM
eurjchem-2350	66	58	409.712	409.712	NUM
eurjchem-2350	66	59	424.727	424.727	NUM
eurjchem-2350	66	60	411.685	411.685	NUM
eurjchem-2350	66	61	130–725	130–725	NUM
eurjchem-2350	66	62	dipole	dipole	NOUN
eurjchem-2350	66	63	9.881	9.881	NUM
eurjchem-2350	66	64	9.490	9.490	NUM
eurjchem-2350	66	65	9.433	9.433	NUM
eurjchem-2350	66	66	5.564	5.564	NUM
eurjchem-2350	66	67	8.809	8.809	NUM
eurjchem-2350	66	68	8.639	8.639	NUM
eurjchem-2350	66	69	8.333	8.333	NUM
eurjchem-2350	66	70	4.534	4.534	NUM
eurjchem-2350	66	71	8.049	8.049	NUM
eurjchem-2350	66	72	3.801	3.801	NUM
eurjchem-2350	66	73	1.0–12.5	1.0–12.5	NUM
eurjchem-2350	66	74	sasa	sasa	NOUN
eurjchem-2350	66	75	582.576	582.576	NUM
eurjchem-2350	66	76	627.028	627.028	NUM
eurjchem-2350	66	77	659.946	659.946	NUM
eurjchem-2350	66	78	679.513	679.513	NUM
eurjchem-2350	66	79	628.960	628.960	NUM
eurjchem-2350	66	80	611.660	611.660	NUM
eurjchem-2350	66	81	656.071	656.071	NUM
eurjchem-2350	66	82	674.964	674.964	NUM
eurjchem-2350	66	83	690.538	690.538	NUM
eurjchem-2350	66	84	643.975	643.975	NUM
eurjchem-2350	66	85	300.0–1000.0	300.0–1000.0	NUM
eurjchem-2350	66	86	donor	donor	NOUN
eurjchem-2350	66	87	hb	hb	ADP
eurjchem-2350	66	88	1	1	NUM
eurjchem-2350	66	89	1	1	NUM
eurjchem-2350	66	90	1	1	NUM
eurjchem-2350	66	91	1	1	NUM
eurjchem-2350	66	92	1	1	NUM
eurjchem-2350	66	93	1	1	NUM
eurjchem-2350	66	94	1	1	NUM
eurjchem-2350	66	95	1	1	NUM
eurjchem-2350	66	96	1	1	NUM
eurjchem-2350	66	97	1	1	NUM
eurjchem-2350	66	98	0.0–6.0	0.0–6.0	NOUN
eurjchem-2350	66	99	accept	accept	VERB
eurjchem-2350	66	100	hb	hb	PROPN
eurjchem-2350	66	101	5.5	5.5	NUM
eurjchem-2350	66	102	5.5	5.5	NUM
eurjchem-2350	66	103	5.5	5.5	NUM
eurjchem-2350	66	104	5.5	5.5	NUM
eurjchem-2350	66	105	7.2	7.2	NUM
eurjchem-2350	66	106	5.5	5.5	NUM
eurjchem-2350	66	107	5.5	5.5	NUM
eurjchem-2350	66	108	5.5	5.5	NUM
eurjchem-2350	66	109	7.5	7.5	NUM
eurjchem-2350	66	110	7.2	7.2	NUM
eurjchem-2350	66	111	2.0–20.0	2.0–20.0	NUM
eurjchem-2350	66	112	qplogpoct	qplogpoct	NOUN
eurjchem-2350	66	113	15.946	15.946	NUM
eurjchem-2350	66	114	16.495	16.495	NUM
eurjchem-2350	66	115	17.598	17.598	NUM
eurjchem-2350	66	116	17.522	17.522	NUM
eurjchem-2350	66	117	17.837	17.837	NUM
eurjchem-2350	66	118	16.423	16.423	NUM
eurjchem-2350	66	119	17.046	17.046	NUM
eurjchem-2350	66	120	17.385	17.385	NUM
eurjchem-2350	66	121	19.474	19.474	NUM
eurjchem-2350	66	122	17.657	17.657	NUM
eurjchem-2350	66	123	8.0–35.0	8.0–35.0	NUM
eurjchem-2350	66	124	qplogpw	qplogpw	NOUN
eurjchem-2350	66	125	9.053	9.053	NUM
eurjchem-2350	66	126	8.570	8.570	NUM
eurjchem-2350	66	127	9.095	9.095	NUM
eurjchem-2350	66	128	9.062	9.062	NUM
eurjchem-2350	66	129	10.700	10.700	NUM
eurjchem-2350	66	130	8.822	8.822	NUM
eurjchem-2350	66	131	8.338	8.338	NUM
eurjchem-2350	66	132	8.969	8.969	NUM
eurjchem-2350	67	1	10.998	10.998	NUM
eurjchem-2350	67	2	10.574	10.574	NUM
eurjchem-2350	67	3	4.0–45.0	4.0–45.0	NUM
eurjchem-2350	67	4	qplogbb	qplogbb	VERB
eurjchem-2350	67	5	0.015	0.015	NUM
eurjchem-2350	67	6	0.103	0.103	NUM
eurjchem-2350	67	7	-0.160	-0.160	NOUN
eurjchem-2350	67	8	-0.069	-0.069	PUNCT
eurjchem-2350	67	9	-0.128	-0.128	NOUN
eurjchem-2350	67	10	0.184	0.184	NUM
eurjchem-2350	67	11	0.278	0.278	NUM
eurjchem-2350	67	12	0.131	0.131	NUM
eurjchem-2350	67	13	0.516	0.516	NUM
eurjchem-2350	67	14	0.158	0.158	NUM
eurjchem-2350	67	15	-3.0–1.2	-3.0–1.2	NOUN
eurjchem-2350	67	16	ip	ip	NOUN
eurjchem-2350	67	17	(	(	PUNCT
eurjchem-2350	67	18	ev	ev	NOUN
eurjchem-2350	67	19	)	)	PUNCT
eurjchem-2350	67	20	8.917	8.917	NUM
eurjchem-2350	67	21	8.883	8.883	NUM
eurjchem-2350	67	22	8.986	8.986	NUM
eurjchem-2350	67	23	8.843	8.843	NUM
eurjchem-2350	67	24	9.015	9.015	NUM
eurjchem-2350	67	25	9.066	9.066	NUM
eurjchem-2350	67	26	9.030	9.030	NUM
eurjchem-2350	67	27	9.053	9.053	NUM
eurjchem-2350	67	28	9.099	9.099	NUM
eurjchem-2350	67	29	9.097	9.097	NUM
eurjchem-2350	67	30	7.9	7.9	NUM
eurjchem-2350	67	31	–	–	PUNCT
eurjchem-2350	67	32	0.5	0.5	NUM
eurjchem-2350	67	33	ea	ea	SYM
eurjchem-2350	67	34	(	(	PUNCT
eurjchem-2350	67	35	ev	ev	INTJ
eurjchem-2350	67	36	)	)	PUNCT
eurjchem-2350	67	37	1.216	1.216	NUM
eurjchem-2350	67	38	1.187	1.187	NUM
eurjchem-2350	67	39	1.258	1.258	NUM
eurjchem-2350	67	40	1.112	1.112	NUM
eurjchem-2350	67	41	1.288	1.288	NUM
eurjchem-2350	67	42	1.386	1.386	NUM
eurjchem-2350	67	43	1.357	1.357	NUM
eurjchem-2350	67	44	1.344	1.344	NUM
eurjchem-2350	67	45	1.413	1.413	NUM
eurjchem-2350	67	46	1.380	1.380	NUM
eurjchem-2350	67	47	-0.9–1.7	-0.9–1.7	PROPN
eurjchem-2350	67	48	human	human	ADJ
eurjchem-2350	67	49	oral	oral	ADJ
eurjchem-2350	67	50	absorption	absorption	NOUN
eurjchem-2350	67	51	3	3	NUM
eurjchem-2350	67	52	3	3	NUM
eurjchem-2350	67	53	3	3	NUM
eurjchem-2350	67	54	3	3	NUM
eurjchem-2350	67	55	3	3	NUM
eurjchem-2350	67	56	3	3	NUM
eurjchem-2350	67	57	3	3	NUM
eurjchem-2350	67	58	3	3	NUM
eurjchem-2350	67	59	3	3	NUM
eurjchem-2350	67	60	3	3	NUM
eurjchem-2350	67	61	1	1	NUM
eurjchem-2350	67	62	,	,	PUNCT
eurjchem-2350	67	63	2	2	NUM
eurjchem-2350	67	64	,	,	PUNCT
eurjchem-2350	67	65	or	or	CCONJ
eurjchem-2350	67	66	3	3	NUM
eurjchem-2350	67	67	for	for	ADP
eurjchem-2350	67	68	low	low	ADJ
eurjchem-2350	67	69	,	,	PUNCT
eurjchem-2350	67	70	medium	medium	ADJ
eurjchem-2350	67	71	,	,	PUNCT
eurjchem-2350	67	72	or	or	CCONJ
eurjchem-2350	67	73	high	high	ADJ
eurjchem-2350	67	74	%	%	NOUN
eurjchem-2350	67	75	human	human	ADJ
eurjchem-2350	67	76	oral	oral	ADJ
eurjchem-2350	67	77	absorption	absorption	NOUN
eurjchem-2350	67	78	in	in	ADP
eurjchem-2350	67	79	gi	gi	NUM
eurjchem-2350	67	80	89.020	89.020	NUM
eurjchem-2350	67	81	100	100	NUM
eurjchem-2350	67	82	91.596	91.596	NUM
eurjchem-2350	67	83	95.012	95.012	NUM
eurjchem-2350	67	84	85.581	85.581	NUM
eurjchem-2350	67	85	92.328	92.328	NUM
eurjchem-2350	67	86	100	100	NUM
eurjchem-2350	67	87	96.252	96.252	NUM
eurjchem-2350	67	88	78.831	78.831	NUM
eurjchem-2350	67	89	90.305	90.305	NUM
eurjchem-2350	67	90	>	>	SYM
eurjchem-2350	67	91	80	80	NUM
eurjchem-2350	67	92	%	%	NOUN
eurjchem-2350	67	93	is	be	AUX
eurjchem-2350	67	94	high	high	ADJ
eurjchem-2350	67	95	psa	psa	VERB
eurjchem-2350	67	96	65.213	65.213	NUM
eurjchem-2350	67	97	62.687	62.687	NUM
eurjchem-2350	67	98	78.825	78.825	NUM
eurjchem-2350	67	99	78.862	78.862	NUM
eurjchem-2350	67	100	88.295	88.295	NUM
eurjchem-2350	67	101	65.229	65.229	NUM
eurjchem-2350	67	102	62.689	62.689	NUM
eurjchem-2350	67	103	65.994	65.994	NUM
eurjchem-2350	67	104	70.681	70.681	NUM
eurjchem-2350	67	105	75.465	75.465	NUM
eurjchem-2350	67	106	7.0–200.0	7.0–200.0	NUM
eurjchem-2350	67	107	rule	rule	NOUN
eurjchem-2350	67	108	of	of	ADP
eurjchem-2350	67	109	five	five	NUM
eurjchem-2350	67	110	0	0	NUM
eurjchem-2350	67	111	0	0	NUM
eurjchem-2350	67	112	0	0	NUM
eurjchem-2350	67	113	0	0	NUM
eurjchem-2350	67	114	0	0	NUM
eurjchem-2350	67	115	0	0	NUM
eurjchem-2350	67	116	0	0	NUM
eurjchem-2350	67	117	0	0	NUM
eurjchem-2350	67	118	0	0	NUM
eurjchem-2350	67	119	0	0	NUM
eurjchem-2350	67	120	maximum	maximum	NOUN
eurjchem-2350	67	121	is	be	AUX
eurjchem-2350	67	122	4	4	NUM
eurjchem-2350	67	123	rule	rule	NOUN
eurjchem-2350	67	124	of	of	ADP
eurjchem-2350	67	125	three	three	NUM
eurjchem-2350	67	126	0	0	NUM
eurjchem-2350	67	127	0	0	NUM
eurjchem-2350	67	128	0	0	NUM
eurjchem-2350	67	129	0	0	NUM
eurjchem-2350	67	130	0	0	NUM
eurjchem-2350	67	131	0	0	NUM
eurjchem-2350	67	132	0	0	NUM
eurjchem-2350	67	133	0	0	NUM
eurjchem-2350	67	134	0	0	NUM
eurjchem-2350	67	135	0	0	NUM
eurjchem-2350	67	136	maximum	maximum	NOUN
eurjchem-2350	67	137	is	be	AUX
eurjchem-2350	67	138	3	3	NUM
eurjchem-2350	67	139	the	the	DET
eurjchem-2350	67	140	chemical	chemical	NOUN
eurjchem-2350	67	141	structures	structure	NOUN
eurjchem-2350	67	142	of	of	ADP
eurjchem-2350	67	143	hcq	hcq	NOUN
eurjchem-2350	67	144	and	and	CCONJ
eurjchem-2350	67	145	rdv	rdv	NOUN
eurjchem-2350	67	146	were	be	AUX
eurjchem-2350	67	147	extracted	extract	VERB
eurjchem-2350	67	148	from	from	ADP
eurjchem-2350	67	149	the	the	DET
eurjchem-2350	67	150	drugbank	drugbank	NOUN
eurjchem-2350	67	151	database	database	NOUN
eurjchem-2350	67	152	in	in	ADP
eurjchem-2350	67	153	two	two	NUM
eurjchem-2350	67	154	-	-	PUNCT
eurjchem-2350	67	155	dimensional	dimensional	ADJ
eurjchem-2350	67	156	mdl	mdl	NOUN
eurjchem-2350	67	157	/	/	SYM
eurjchem-2350	67	158	mol	mol	NOUN
eurjchem-2350	67	159	format	format	NOUN
eurjchem-2350	67	160	[	[	X
eurjchem-2350	67	161	31	31	NUM
eurjchem-2350	67	162	]	]	PUNCT
eurjchem-2350	67	163	.	.	PUNCT
eurjchem-2350	68	1	the	the	DET
eurjchem-2350	68	2	smiles	smile	NOUN
eurjchem-2350	68	3	was	be	AUX
eurjchem-2350	68	4	also	also	ADV
eurjchem-2350	68	5	submitted	submit	VERB
eurjchem-2350	68	6	to	to	ADP
eurjchem-2350	68	7	the	the	DET
eurjchem-2350	68	8	qikprop	qikprop	NOUN
eurjchem-2350	68	9	tool	tool	NOUN
eurjchem-2350	68	10	for	for	ADP
eurjchem-2350	68	11	adme	adme	NOUN
eurjchem-2350	68	12	prediction	prediction	NOUN
eurjchem-2350	68	13	.	.	PUNCT
eurjchem-2350	69	1	all	all	DET
eurjchem-2350	69	2	ligands	ligand	NOUN
eurjchem-2350	69	3	were	be	AUX
eurjchem-2350	69	4	subjected	subject	VERB
eurjchem-2350	69	5	to	to	ADP
eurjchem-2350	69	6	energy	energy	NOUN
eurjchem-2350	69	7	minimization	minimization	NOUN
eurjchem-2350	69	8	and	and	CCONJ
eurjchem-2350	69	9	a	a	DET
eurjchem-2350	69	10	pdbqt	pdbqt	NOUN
eurjchem-2350	69	11	file	file	NOUN
eurjchem-2350	69	12	was	be	AUX
eurjchem-2350	69	13	generated	generate	VERB
eurjchem-2350	69	14	using	use	VERB
eurjchem-2350	69	15	the	the	DET
eurjchem-2350	69	16	prodrg	prodrg	NOUN
eurjchem-2350	69	17	(	(	PUNCT
eurjchem-2350	69	18	http://prodrg1.dyndns.org/submit.html	http://prodrg1.dyndns.org/submit.html	NOUN
eurjchem-2350	69	19	)	)	PUNCT
eurjchem-2350	69	20	web	web	NOUN
eurjchem-2350	69	21	server	server	NOUN
eurjchem-2350	70	1	[	[	X
eurjchem-2350	70	2	32	32	NUM
eurjchem-2350	70	3	]	]	PUNCT
eurjchem-2350	70	4	.	.	PUNCT
eurjchem-2350	71	1	2.3	2.3	NUM
eurjchem-2350	71	2	.	.	PUNCT
eurjchem-2350	72	1	protein	protein	NOUN
eurjchem-2350	72	2	preparation	preparation	NOUN
eurjchem-2350	72	3	in	in	ADP
eurjchem-2350	72	4	general	general	ADJ
eurjchem-2350	72	5	,	,	PUNCT
eurjchem-2350	72	6	prior	prior	ADV
eurjchem-2350	72	7	to	to	ADP
eurjchem-2350	72	8	docking	docking	NOUN
eurjchem-2350	72	9	,	,	PUNCT
eurjchem-2350	72	10	protein	protein	NOUN
eurjchem-2350	72	11	crystal	crystal	NOUN
eurjchem-2350	72	12	structures	structure	NOUN
eurjchem-2350	72	13	are	be	AUX
eurjchem-2350	72	14	programmed	program	VERB
eurjchem-2350	72	15	to	to	PART
eurjchem-2350	72	16	add	add	VERB
eurjchem-2350	72	17	hydrogen	hydrogen	NOUN
eurjchem-2350	72	18	atoms	atom	NOUN
eurjchem-2350	72	19	,	,	PUNCT
eurjchem-2350	72	20	optimize	optimize	VERB
eurjchem-2350	72	21	the	the	DET
eurjchem-2350	72	22	hydrogen	hydrogen	NOUN
eurjchem-2350	72	23	bonds	bond	NOUN
eurjchem-2350	72	24	,	,	PUNCT
eurjchem-2350	72	25	eliminate	eliminate	VERB
eurjchem-2350	72	26	atomic	atomic	ADJ
eurjchem-2350	72	27	disagreements	disagreement	NOUN
eurjchem-2350	72	28	,	,	PUNCT
eurjchem-2350	72	29	and	and	CCONJ
eurjchem-2350	72	30	perform	perform	VERB
eurjchem-2350	72	31	other	other	ADJ
eurjchem-2350	72	32	operations	operation	NOUN
eurjchem-2350	72	33	that	that	PRON
eurjchem-2350	72	34	are	be	AUX
eurjchem-2350	72	35	not	not	PART
eurjchem-2350	72	36	part	part	NOUN
eurjchem-2350	72	37	of	of	ADP
eurjchem-2350	72	38	the	the	DET
eurjchem-2350	72	39	process	process	NOUN
eurjchem-2350	72	40	of	of	ADP
eurjchem-2350	72	41	configuration	configuration	NOUN
eurjchem-2350	72	42	of	of	ADP
eurjchem-2350	72	43	the	the	DET
eurjchem-2350	72	44	x	x	ADJ
eurjchem-2350	72	45	-	-	NOUN
eurjchem-2350	72	46	ray	ray	NOUN
eurjchem-2350	72	47	crystal	crystal	NOUN
eurjchem-2350	72	48	structure	structure	NOUN
eurjchem-2350	73	1	[	[	X
eurjchem-2350	73	2	33	33	NUM
eurjchem-2350	73	3	]	]	PUNCT
eurjchem-2350	73	4	.	.	PUNCT
eurjchem-2350	74	1	the	the	DET
eurjchem-2350	74	2	structures	structure	NOUN
eurjchem-2350	74	3	of	of	ADP
eurjchem-2350	74	4	covid-19	covid-19	PROPN
eurjchem-2350	74	5	main	main	ADJ
eurjchem-2350	74	6	proteases	protease	NOUN
eurjchem-2350	74	7	were	be	AUX
eurjchem-2350	74	8	obtained	obtain	VERB
eurjchem-2350	74	9	from	from	ADP
eurjchem-2350	74	10	rcsb	rcsb	ADJ
eurjchem-2350	74	11	protein	protein	NOUN
eurjchem-2350	74	12	data	datum	NOUN
eurjchem-2350	74	13	bank	bank	PROPN
eurjchem-2350	74	14	(	(	PUNCT
eurjchem-2350	74	15	https://www.pdb.org	https://www.pdb.org	PROPN
eurjchem-2350	74	16	)	)	PUNCT
eurjchem-2350	74	17	.	.	PUNCT
eurjchem-2350	75	1	we	we	PRON
eurjchem-2350	75	2	have	have	AUX
eurjchem-2350	75	3	chosen	choose	VERB
eurjchem-2350	75	4	the	the	DET
eurjchem-2350	75	5	crystal	crystal	NOUN
eurjchem-2350	75	6	structures	structure	NOUN
eurjchem-2350	75	7	of	of	ADP
eurjchem-2350	75	8	all	all	DET
eurjchem-2350	75	9	five	five	NUM
eurjchem-2350	75	10	covid-19	covid-19	PROPN
eurjchem-2350	75	11	mpro	mpro	NOUN
eurjchem-2350	75	12	that	that	PRON
eurjchem-2350	75	13	have	have	AUX
eurjchem-2350	75	14	been	be	AUX
eurjchem-2350	75	15	recently	recently	ADV
eurjchem-2350	75	16	deposited	deposit	VERB
eurjchem-2350	75	17	and	and	CCONJ
eurjchem-2350	75	18	available	available	ADJ
eurjchem-2350	75	19	in	in	ADP
eurjchem-2350	75	20	the	the	DET
eurjchem-2350	75	21	protein	protein	NOUN
eurjchem-2350	75	22	data	datum	NOUN
eurjchem-2350	75	23	bank	bank	NOUN
eurjchem-2350	75	24	.	.	PUNCT
eurjchem-2350	76	1	both	both	PRON
eurjchem-2350	76	2	unliganded	unligande	VERB
eurjchem-2350	76	3	and	and	CCONJ
eurjchem-2350	76	4	liganded	ligande	VERB
eurjchem-2350	76	5	forms	form	NOUN
eurjchem-2350	76	6	of	of	ADP
eurjchem-2350	76	7	proteins	protein	NOUN
eurjchem-2350	76	8	were	be	AUX
eurjchem-2350	76	9	selected	select	VERB
eurjchem-2350	76	10	(	(	PUNCT
eurjchem-2350	76	11	pdb	pdb	PROPN
eurjchem-2350	76	12	i	i	PROPN
eurjchem-2350	76	13	d	d	PROPN
eurjchem-2350	76	14	:	:	PUNCT
eurjchem-2350	76	15	6lu7	6lu7	NUM
eurjchem-2350	77	1	[	[	X
eurjchem-2350	77	2	34	34	NUM
eurjchem-2350	77	3	]	]	PUNCT
eurjchem-2350	77	4	,	,	PUNCT
eurjchem-2350	77	5	6w63	6w63	NUM
eurjchem-2350	78	1	[	[	X
eurjchem-2350	78	2	35	35	NUM
eurjchem-2350	78	3	]	]	PUNCT
eurjchem-2350	78	4	,	,	PUNCT
eurjchem-2350	78	5	6m03	6m03	NOUN
eurjchem-2350	79	1	[	[	X
eurjchem-2350	79	2	36	36	NUM
eurjchem-2350	79	3	]	]	PUNCT
eurjchem-2350	79	4	,	,	PUNCT
eurjchem-2350	79	5	6yb7	6yb7	NUM
eurjchem-2350	80	1	[	[	X
eurjchem-2350	80	2	37	37	NUM
eurjchem-2350	80	3	]	]	PUNCT
eurjchem-2350	80	4	and	and	CCONJ
eurjchem-2350	80	5	6y84	6y84	NOUN
eurjchem-2350	81	1	[	[	X
eurjchem-2350	81	2	38	38	NUM
eurjchem-2350	81	3	]	]	PUNCT
eurjchem-2350	81	4	)	)	PUNCT
eurjchem-2350	81	5	.	.	PUNCT
eurjchem-2350	82	1	all	all	DET
eurjchem-2350	82	2	water	water	NOUN
eurjchem-2350	82	3	molecules	molecule	NOUN
eurjchem-2350	82	4	were	be	AUX
eurjchem-2350	82	5	removed	remove	VERB
eurjchem-2350	82	6	,	,	PUNCT
eurjchem-2350	82	7	and	and	CCONJ
eurjchem-2350	82	8	polar	polar	ADJ
eurjchem-2350	82	9	hydrogen	hydrogen	NOUN
eurjchem-2350	82	10	atoms	atom	NOUN
eurjchem-2350	82	11	were	be	AUX
eurjchem-2350	82	12	added	add	VERB
eurjchem-2350	82	13	to	to	ADP
eurjchem-2350	82	14	the	the	DET
eurjchem-2350	82	15	target	target	NOUN
eurjchem-2350	82	16	protein	protein	NOUN
eurjchem-2350	82	17	molecule	molecule	NOUN
eurjchem-2350	82	18	.	.	PUNCT
eurjchem-2350	83	1	2.4	2.4	NUM
eurjchem-2350	83	2	.	.	PUNCT
eurjchem-2350	83	3	prediction	prediction	NOUN
eurjchem-2350	83	4	of	of	ADP
eurjchem-2350	83	5	active	active	ADJ
eurjchem-2350	83	6	sites	site	NOUN
eurjchem-2350	83	7	ligand	ligand	VERB
eurjchem-2350	83	8	binding	bind	VERB
eurjchem-2350	83	9	sites	site	NOUN
eurjchem-2350	83	10	are	be	AUX
eurjchem-2350	83	11	the	the	DET
eurjchem-2350	83	12	active	active	ADJ
eurjchem-2350	83	13	regions	region	NOUN
eurjchem-2350	83	14	of	of	ADP
eurjchem-2350	83	15	receptors	receptor	NOUN
eurjchem-2350	83	16	that	that	PRON
eurjchem-2350	83	17	control	control	VERB
eurjchem-2350	83	18	protein	protein	NOUN
eurjchem-2350	83	19	functionalities	functionality	NOUN
eurjchem-2350	83	20	.	.	PUNCT
eurjchem-2350	84	1	therefore	therefore	ADV
eurjchem-2350	84	2	,	,	PUNCT
eurjchem-2350	84	3	the	the	DET
eurjchem-2350	84	4	finding	finding	NOUN
eurjchem-2350	84	5	of	of	ADP
eurjchem-2350	84	6	specific	specific	ADJ
eurjchem-2350	84	7	binding	bind	VERB
eurjchem-2350	84	8	sites	site	NOUN
eurjchem-2350	84	9	is	be	AUX
eurjchem-2350	84	10	the	the	DET
eurjchem-2350	84	11	first	first	ADJ
eurjchem-2350	84	12	step	step	NOUN
eurjchem-2350	84	13	in	in	ADP
eurjchem-2350	84	14	studying	study	VERB
eurjchem-2350	84	15	the	the	DET
eurjchem-2350	84	16	functions	function	NOUN
eurjchem-2350	84	17	of	of	ADP
eurjchem-2350	84	18	proteins	protein	NOUN
eurjchem-2350	84	19	and	and	CCONJ
eurjchem-2350	84	20	structure	structure	NOUN
eurjchem-2350	84	21	-	-	PUNCT
eurjchem-2350	84	22	based	base	VERB
eurjchem-2350	84	23	drug	drug	NOUN
eurjchem-2350	84	24	design	design	NOUN
eurjchem-2350	84	25	.	.	PUNCT
eurjchem-2350	85	1	metapocket	metapocket	NOUN
eurjchem-2350	85	2	program	program	NOUN
eurjchem-2350	85	3	offers	offer	VERB
eurjchem-2350	85	4	a	a	DET
eurjchem-2350	85	5	systematic	systematic	ADJ
eurjchem-2350	85	6	approach	approach	NOUN
eurjchem-2350	85	7	to	to	PART
eurjchem-2350	85	8	identify	identify	VERB
eurjchem-2350	85	9	ligand	ligand	NOUN
eurjchem-2350	85	10	-	-	PUNCT
eurjchem-2350	85	11	binding	bind	VERB
eurjchem-2350	85	12	sites	site	NOUN
eurjchem-2350	85	13	using	use	VERB
eurjchem-2350	85	14	eight	eight	NUM
eurjchem-2350	85	15	methods	method	NOUN
eurjchem-2350	85	16	.	.	PUNCT
eurjchem-2350	86	1	they	they	PRON
eurjchem-2350	86	2	are	be	AUX
eurjchem-2350	86	3	surfnet	surfnet	NOUN
eurjchem-2350	86	4	,	,	PUNCT
eurjchem-2350	86	5	fpocket	fpocket	NOUN
eurjchem-2350	86	6	,	,	PUNCT
eurjchem-2350	86	7	ligsite	ligsite	NOUN
eurjchem-2350	86	8	,	,	PUNCT
eurjchem-2350	86	9	concavity	concavity	NOUN
eurjchem-2350	86	10	,	,	PUNCT
eurjchem-2350	86	11	move	move	VERB
eurjchem-2350	86	12	,	,	PUNCT
eurjchem-2350	86	13	poc	poc	PROPN
eurjchem-2350	86	14	asa	asa	PROPN
eurjchem-2350	86	15	,	,	PUNCT
eurjchem-2350	86	16	q	q	ADJ
eurjchem-2350	86	17	-	-	PUNCT
eurjchem-2350	86	18	site	site	NOUN
eurjchem-2350	86	19	finder	finder	NOUN
eurjchem-2350	86	20	and	and	CCONJ
eurjchem-2350	86	21	ghecom	ghecom	PROPN
eurjchem-2350	86	22	.	.	PUNCT
eurjchem-2350	87	1	we	we	PRON
eurjchem-2350	87	2	have	have	AUX
eurjchem-2350	87	3	used	use	VERB
eurjchem-2350	87	4	the	the	DET
eurjchem-2350	87	5	metapocket	metapocket	NOUN
eurjchem-2350	87	6	web	web	NOUN
eurjchem-2350	87	7	server	server	NOUN
eurjchem-2350	87	8	,	,	PUNCT
eurjchem-2350	87	9	which	which	PRON
eurjchem-2350	87	10	has	have	AUX
eurjchem-2350	87	11	already	already	ADV
eurjchem-2350	87	12	been	be	AUX
eurjchem-2350	87	13	widely	widely	ADV
eurjchem-2350	87	14	used	use	VERB
eurjchem-2350	87	15	to	to	PART
eurjchem-2350	87	16	predict	predict	VERB
eurjchem-2350	87	17	binding	bind	VERB
eurjchem-2350	87	18	sites	site	NOUN
eurjchem-2350	87	19	[	[	X
eurjchem-2350	87	20	39	39	NUM
eurjchem-2350	87	21	-	-	SYM
eurjchem-2350	87	22	40	40	NUM
eurjchem-2350	87	23	]	]	PUNCT
eurjchem-2350	87	24	.	.	PUNCT
eurjchem-2350	88	1	2.5	2.5	NUM
eurjchem-2350	88	2	.	.	PUNCT
eurjchem-2350	89	1	molecular	molecular	ADJ
eurjchem-2350	89	2	docking	docking	NOUN
eurjchem-2350	89	3	and	and	CCONJ
eurjchem-2350	89	4	analysis	analysis	NOUN
eurjchem-2350	89	5	the	the	DET
eurjchem-2350	89	6	structure	structure	NOUN
eurjchem-2350	89	7	of	of	ADP
eurjchem-2350	89	8	the	the	DET
eurjchem-2350	89	9	target	target	NOUN
eurjchem-2350	89	10	mpro	mpro	ADJ
eurjchem-2350	89	11	of	of	ADP
eurjchem-2350	89	12	covid-19	covid-19	PROPN
eurjchem-2350	89	13	(	(	PUNCT
eurjchem-2350	89	14	pdb	pdb	PROPN
eurjchem-2350	89	15	i	i	PROPN
eurjchem-2350	89	16	d	d	PROPN
eurjchem-2350	89	17	:	:	PUNCT
eurjchem-2350	89	18	6lu7	6lu7	NUM
eurjchem-2350	89	19	,	,	PUNCT
eurjchem-2350	89	20	6w63	6w63	NUM
eurjchem-2350	89	21	,	,	PUNCT
eurjchem-2350	89	22	6m03	6m03	NOUN
eurjchem-2350	89	23	,	,	PUNCT
eurjchem-2350	89	24	6yb7and6y84	6yb7and6y84	NUM
eurjchem-2350	89	25	)	)	PUNCT
eurjchem-2350	89	26	was	be	AUX
eurjchem-2350	89	27	derived	derive	VERB
eurjchem-2350	89	28	from	from	ADP
eurjchem-2350	89	29	the	the	DET
eurjchem-2350	89	30	protein	protein	NOUN
eurjchem-2350	89	31	data	datum	NOUN
eurjchem-2350	89	32	bank	bank	NOUN
eurjchem-2350	89	33	.	.	PUNCT
eurjchem-2350	90	1	these	these	DET
eurjchem-2350	90	2	target	target	NOUN
eurjchem-2350	90	3	receptors	receptor	NOUN
eurjchem-2350	90	4	were	be	AUX
eurjchem-2350	90	5	performed	perform	VERB
eurjchem-2350	90	6	with	with	ADP
eurjchem-2350	90	7	chimera	chimera	NOUN
eurjchem-2350	90	8	5.3.1	5.3.1	PROPN
eurjchem-2350	90	9	software	software	NOUN
eurjchem-2350	90	10	(	(	PUNCT
eurjchem-2350	90	11	rbvi	rbvi	NOUN
eurjchem-2350	90	12	,	,	PUNCT
eurjchem-2350	90	13	resource	resource	NOUN
eurjchem-2350	90	14	for	for	ADP
eurjchem-2350	90	15	biocomputing	biocomputing	NOUN
eurjchem-2350	90	16	,	,	PUNCT
eurjchem-2350	90	17	visualization	visualization	NOUN
eurjchem-2350	90	18	and	and	CCONJ
eurjchem-2350	90	19	informatics	informatic	NOUN
eurjchem-2350	90	20	,	,	PUNCT
eurjchem-2350	90	21	university	university	PROPN
eurjchem-2350	90	22	of	of	ADP
eurjchem-2350	90	23	california	california	PROPN
eurjchem-2350	90	24	,	,	PUNCT
eurjchem-2350	90	25	ca	ca	PROPN
eurjchem-2350	90	26	,	,	PUNCT
eurjchem-2350	90	27	usa	usa	PROPN
eurjchem-2350	90	28	,	,	PUNCT
eurjchem-2350	90	29	www.cgl.ucsf.edu/chimera/	www.cgl.ucsf.edu/chimera/	NUM
eurjchem-2350	90	30	)	)	PUNCT
eurjchem-2350	91	1	[	[	X
eurjchem-2350	91	2	41	41	NUM
eurjchem-2350	91	3	]	]	PUNCT
eurjchem-2350	91	4	.	.	PUNCT
eurjchem-2350	92	1	docking	dock	VERB
eurjchem-2350	92	2	studies	study	NOUN
eurjchem-2350	92	3	were	be	AUX
eurjchem-2350	92	4	performed	perform	VERB
eurjchem-2350	92	5	with	with	ADP
eurjchem-2350	92	6	autodock	autodock	NOUN
eurjchem-2350	92	7	4.2	4.2	NUM
eurjchem-2350	92	8	software	software	NOUN
eurjchem-2350	92	9	(	(	PUNCT
eurjchem-2350	92	10	https://autodock	https://autodock	NOUN
eurjchem-2350	92	11	.	.	NOUN
eurjchem-2350	92	12	scripps.edu/	scripps.edu/	NOUN
eurjchem-2350	92	13	)	)	PUNCT
eurjchem-2350	92	14	provided	provide	VERB
eurjchem-2350	92	15	with	with	ADP
eurjchem-2350	92	16	autodock	autodock	NOUN
eurjchem-2350	92	17	tools	tool	NOUN
eurjchem-2350	92	18	1.5.4	1.5.4	NUM
eurjchem-2350	92	19	graphical	graphical	ADJ
eurjchem-2350	92	20	interface	interface	NOUN
eurjchem-2350	92	21	[	[	X
eurjchem-2350	92	22	42	42	NUM
eurjchem-2350	92	23	]	]	PUNCT
eurjchem-2350	92	24	.	.	PUNCT
eurjchem-2350	93	1	for	for	ADP
eurjchem-2350	93	2	the	the	DET
eurjchem-2350	93	3	analysis	analysis	NOUN
eurjchem-2350	93	4	of	of	ADP
eurjchem-2350	93	5	receptor	receptor	NOUN
eurjchem-2350	93	6	-	-	PUNCT
eurjchem-2350	93	7	ligand	ligand	NOUN
eurjchem-2350	93	8	interactions	interaction	NOUN
eurjchem-2350	93	9	,	,	PUNCT
eurjchem-2350	93	10	an	an	PRON
eurjchem-2350	93	11	in	in	ADP
eurjchem-2350	93	12	silico	silico	NOUN
eurjchem-2350	93	13	screening	screen	VERB
eurjchem-2350	93	14	pipeline	pipeline	NOUN
eurjchem-2350	93	15	was	be	AUX
eurjchem-2350	93	16	designed	design	VERB
eurjchem-2350	93	17	.	.	PUNCT
eurjchem-2350	94	1	2.6	2.6	NUM
eurjchem-2350	94	2	.	.	PUNCT
eurjchem-2350	94	3	prediction	prediction	NOUN
eurjchem-2350	94	4	of	of	ADP
eurjchem-2350	94	5	adme	adme	NOUN
eurjchem-2350	94	6	descriptors	descriptor	NOUN
eurjchem-2350	94	7	and	and	CCONJ
eurjchem-2350	94	8	toxicity	toxicity	NOUN
eurjchem-2350	94	9	of	of	ADP
eurjchem-2350	94	10	quinoline	quinoline	NOUN
eurjchem-2350	94	11	derivatives	derivative	NOUN
eurjchem-2350	94	12	.	.	PUNCT
eurjchem-2350	95	1	the	the	DET
eurjchem-2350	95	2	main	main	ADJ
eurjchem-2350	95	3	reason	reason	NOUN
eurjchem-2350	95	4	why	why	SCONJ
eurjchem-2350	95	5	most	most	ADJ
eurjchem-2350	95	6	drug	drug	NOUN
eurjchem-2350	95	7	candidates	candidate	NOUN
eurjchem-2350	95	8	fail	fail	VERB
eurjchem-2350	95	9	during	during	ADP
eurjchem-2350	95	10	clinical	clinical	ADJ
eurjchem-2350	95	11	trials	trial	NOUN
eurjchem-2350	95	12	is	be	AUX
eurjchem-2350	95	13	the	the	DET
eurjchem-2350	95	14	low	low	ADJ
eurjchem-2350	95	15	adme	adme	NOUN
eurjchem-2350	95	16	and	and	CCONJ
eurjchem-2350	95	17	a	a	DET
eurjchem-2350	95	18	high	high	ADJ
eurjchem-2350	95	19	toxicity	toxicity	NOUN
eurjchem-2350	95	20	profile	profile	NOUN
eurjchem-2350	95	21	.	.	PUNCT
eurjchem-2350	96	1	thus	thus	ADV
eurjchem-2350	96	2	,	,	PUNCT
eurjchem-2350	96	3	in	in	ADP
eurjchem-2350	96	4	the	the	DET
eurjchem-2350	96	5	early	early	ADJ
eurjchem-2350	96	6	stages	stage	NOUN
eurjchem-2350	96	7	of	of	ADP
eurjchem-2350	96	8	drug	drug	NOUN
eurjchem-2350	96	9	development	development	NOUN
eurjchem-2350	96	10	,	,	PUNCT
eurjchem-2350	96	11	an	an	DET
eurjchem-2350	96	12	important	important	ADJ
eurjchem-2350	96	13	element	element	NOUN
eurjchem-2350	96	14	of	of	ADP
eurjchem-2350	96	15	drug	drug	NOUN
eurjchem-2350	96	16	research	research	NOUN
eurjchem-2350	96	17	is	be	AUX
eurjchem-2350	96	18	to	to	PART
eurjchem-2350	96	19	determine	determine	VERB
eurjchem-2350	96	20	the	the	DET
eurjchem-2350	96	21	essential	essential	ADJ
eurjchem-2350	96	22	physio	physio	NOUN
eurjchem-2350	96	23	-	-	PUNCT
eurjchem-2350	96	24	chemical	chemical	NOUN
eurjchem-2350	96	25	and	and	CCONJ
eurjchem-2350	96	26	toxicity	toxicity	NOUN
eurjchem-2350	96	27	profile	profile	NOUN
eurjchem-2350	96	28	of	of	ADP
eurjchem-2350	96	29	the	the	DET
eurjchem-2350	96	30	molecule	molecule	NOUN
eurjchem-2350	96	31	[	[	X
eurjchem-2350	96	32	43	43	NUM
eurjchem-2350	96	33	]	]	PUNCT
eurjchem-2350	96	34	.	.	PUNCT
eurjchem-2350	97	1	qikprop	qikprop	PROPN
eurjchem-2350	97	2	calculates	calculate	VERB
eurjchem-2350	97	3	the	the	DET
eurjchem-2350	97	4	adme	adme	NOUN
eurjchem-2350	97	5	properties	property	NOUN
eurjchem-2350	97	6	(	(	PUNCT
eurjchem-2350	97	7	absorption	absorption	NOUN
eurjchem-2350	97	8	,	,	PUNCT
eurjchem-2350	97	9	distribution	distribution	NOUN
eurjchem-2350	97	10	,	,	PUNCT
eurjchem-2350	97	11	metabolism	metabolism	NOUN
eurjchem-2350	97	12	,	,	PUNCT
eurjchem-2350	97	13	and	and	CCONJ
eurjchem-2350	97	14	excretion	excretion	NOUN
eurjchem-2350	97	15	)	)	PUNCT
eurjchem-2350	97	16	of	of	ADP
eurjchem-2350	97	17	quinoline	quinoline	NOUN
eurjchem-2350	97	18	analogues	analogue	NOUN
eurjchem-2350	97	19	to	to	PART
eurjchem-2350	97	20	predict	predict	VERB
eurjchem-2350	97	21	their	their	PRON
eurjchem-2350	97	22	drugability	drugability	NOUN
eurjchem-2350	97	23	.	.	PUNCT
eurjchem-2350	98	1	the	the	DET
eurjchem-2350	98	2	qikprop	qikprop	NOUN
eurjchem-2350	98	3	3.4	3.4	NUM
eurjchem-2350	98	4	tool	tool	NOUN
eurjchem-2350	98	5	was	be	AUX
eurjchem-2350	98	6	used	use	VERB
eurjchem-2350	98	7	to	to	PART
eurjchem-2350	98	8	predict	predict	VERB
eurjchem-2350	98	9	pharmaceutically	pharmaceutically	ADV
eurjchem-2350	98	10	and	and	CCONJ
eurjchem-2350	98	11	physically	physically	ADV
eurjchem-2350	98	12	significant	significant	ADJ
eurjchem-2350	98	13	descriptors	descriptor	NOUN
eurjchem-2350	98	14	with	with	ADP
eurjchem-2350	98	15	relevant	relevant	ADJ
eurjchem-2350	98	16	adme	adme	NOUN
eurjchem-2350	98	17	properties	property	NOUN
eurjchem-2350	98	18	and	and	CCONJ
eurjchem-2350	98	19	toxicity	toxicity	NOUN
eurjchem-2350	98	20	.	.	PUNCT
eurjchem-2350	99	1	these	these	DET
eurjchem-2350	99	2	descriptors	descriptor	NOUN
eurjchem-2350	99	3	were	be	AUX
eurjchem-2350	99	4	calculated	calculate	VERB
eurjchem-2350	99	5	for	for	ADP
eurjchem-2350	99	6	all	all	DET
eurjchem-2350	99	7	quinoline	quinoline	NOUN
eurjchem-2350	99	8	molecules	molecule	NOUN
eurjchem-2350	99	9	and	and	CCONJ
eurjchem-2350	99	10	compared	compare	VERB
eurjchem-2350	99	11	with	with	ADP
eurjchem-2350	99	12	optimal	optimal	ADJ
eurjchem-2350	99	13	range	range	NOUN
eurjchem-2350	99	14	and	and	CCONJ
eurjchem-2350	99	15	found	find	VERB
eurjchem-2350	99	16	that	that	SCONJ
eurjchem-2350	99	17	all	all	DET
eurjchem-2350	99	18	derivatives	derivative	NOUN
eurjchem-2350	99	19	possessed	possess	VERB
eurjchem-2350	99	20	a	a	DET
eurjchem-2350	99	21	significant	significant	ADJ
eurjchem-2350	99	22	number	number	NOUN
eurjchem-2350	99	23	of	of	ADP
eurjchem-2350	99	24	hydrogen	hydrogen	NOUN
eurjchem-2350	99	25	bond	bond	NOUN
eurjchem-2350	99	26	donors	donor	NOUN
eurjchem-2350	99	27	and	and	CCONJ
eurjchem-2350	99	28	acceptors	acceptor	NOUN
eurjchem-2350	99	29	.	.	PUNCT
eurjchem-2350	100	1	2.7	2.7	NUM
eurjchem-2350	100	2	.	.	X
eurjchem-2350	101	1	molecular	molecular	ADJ
eurjchem-2350	101	2	dynamic	dynamic	ADJ
eurjchem-2350	101	3	simulation	simulation	NOUN
eurjchem-2350	101	4	the	the	DET
eurjchem-2350	101	5	molecular	molecular	ADJ
eurjchem-2350	101	6	dynamic	dynamic	ADJ
eurjchem-2350	101	7	simulation	simulation	NOUN
eurjchem-2350	101	8	analysis	analysis	NOUN
eurjchem-2350	101	9	for	for	ADP
eurjchem-2350	101	10	the	the	DET
eurjchem-2350	101	11	best	good	ADJ
eurjchem-2350	101	12	ligand	ligand	NOUN
eurjchem-2350	101	13	with	with	ADP
eurjchem-2350	101	14	receptors	receptor	NOUN
eurjchem-2350	101	15	was	be	AUX
eurjchem-2350	101	16	carried	carry	VERB
eurjchem-2350	101	17	out	out	ADP
eurjchem-2350	101	18	using	use	VERB
eurjchem-2350	101	19	biovia	biovia	PROPN
eurjchem-2350	101	20	discovery	discovery	PROPN
eurjchem-2350	101	21	studio	studio	PROPN
eurjchem-2350	101	22	version	version	PROPN
eurjchem-2350	101	23	2017	2017	NUM
eurjchem-2350	101	24	.	.	PUNCT
eurjchem-2350	102	1	the	the	DET
eurjchem-2350	102	2	protocol	protocol	NOUN
eurjchem-2350	102	3	for	for	ADP
eurjchem-2350	102	4	standard	standard	ADJ
eurjchem-2350	102	5	dynamic	dynamic	ADJ
eurjchem-2350	102	6	cascade	cascade	NOUN
eurjchem-2350	102	7	and	and	CCONJ
eurjchem-2350	102	8	minimization	minimization	NOUN
eurjchem-2350	102	9	analysis	analysis	NOUN
eurjchem-2350	102	10	was	be	AUX
eurjchem-2350	102	11	followed	follow	VERB
eurjchem-2350	102	12	as	as	SCONJ
eurjchem-2350	102	13	previously	previously	ADV
eurjchem-2350	102	14	described	describe	VERB
eurjchem-2350	102	15	[	[	X
eurjchem-2350	102	16	44	44	NUM
eurjchem-2350	102	17	]	]	PUNCT
eurjchem-2350	102	18	.	.	PUNCT
eurjchem-2350	103	1	3	3	X
eurjchem-2350	103	2	.	.	NOUN
eurjchem-2350	103	3	results	result	NOUN
eurjchem-2350	103	4	and	and	CCONJ
eurjchem-2350	103	5	discussion	discussion	NOUN
eurjchem-2350	103	6	3.1	3.1	NUM
eurjchem-2350	103	7	.	.	PUNCT
eurjchem-2350	104	1	adme	adme	NOUN
eurjchem-2350	104	2	and	and	CCONJ
eurjchem-2350	104	3	toxicity	toxicity	NOUN
eurjchem-2350	104	4	studies	study	NOUN
eurjchem-2350	104	5	to	to	PART
eurjchem-2350	104	6	determine	determine	VERB
eurjchem-2350	104	7	the	the	DET
eurjchem-2350	104	8	admet	admet	NOUN
eurjchem-2350	104	9	properties	property	NOUN
eurjchem-2350	104	10	(	(	PUNCT
eurjchem-2350	104	11	absorption	absorption	NOUN
eurjchem-2350	104	12	,	,	PUNCT
eurjchem-2350	104	13	distribution	distribution	NOUN
eurjchem-2350	104	14	,	,	PUNCT
eurjchem-2350	104	15	metabolism	metabolism	NOUN
eurjchem-2350	104	16	,	,	PUNCT
eurjchem-2350	104	17	excretion	excretion	NOUN
eurjchem-2350	104	18	,	,	PUNCT
eurjchem-2350	104	19	and	and	CCONJ
eurjchem-2350	104	20	toxicity	toxicity	NOUN
eurjchem-2350	104	21	)	)	PUNCT
eurjchem-2350	104	22	of	of	ADP
eurjchem-2350	104	23	compounds	compound	NOUN
eurjchem-2350	104	24	,	,	PUNCT
eurjchem-2350	104	25	physicochemical	physicochemical	ADJ
eurjchem-2350	104	26	parameters	parameter	NOUN
eurjchem-2350	104	27	play	play	VERB
eurjchem-2350	104	28	an	an	DET
eurjchem-2350	104	29	important	important	ADJ
eurjchem-2350	104	30	role	role	NOUN
eurjchem-2350	104	31	[	[	X
eurjchem-2350	104	32	45	45	NUM
eurjchem-2350	104	33	]	]	PUNCT
eurjchem-2350	104	34	.	.	PUNCT
eurjchem-2350	105	1	in	in	ADP
eurjchem-2350	105	2	the	the	DET
eurjchem-2350	105	3	area	area	NOUN
eurjchem-2350	105	4	of	of	ADP
eurjchem-2350	105	5	drug	drug	NOUN
eurjchem-2350	105	6	development	development	NOUN
eurjchem-2350	105	7	,	,	PUNCT
eurjchem-2350	105	8	the	the	DET
eurjchem-2350	105	9	evaluation	evaluation	NOUN
eurjchem-2350	105	10	of	of	ADP
eurjchem-2350	105	11	the	the	DET
eurjchem-2350	105	12	basic	basic	ADJ
eurjchem-2350	105	13	physiochemical	physiochemical	ADJ
eurjchem-2350	105	14	and	and	CCONJ
eurjchem-2350	105	15	toxicity	toxicity	NOUN
eurjchem-2350	105	16	profile	profile	NOUN
eurjchem-2350	105	17	of	of	ADP
eurjchem-2350	105	18	the	the	DET
eurjchem-2350	105	19	molecule	molecule	NOUN
eurjchem-2350	105	20	is	be	AUX
eurjchem-2350	105	21	an	an	DET
eurjchem-2350	105	22	important	important	ADJ
eurjchem-2350	105	23	aspect	aspect	NOUN
eurjchem-2350	105	24	of	of	ADP
eurjchem-2350	105	25	drug	drug	NOUN
eurjchem-2350	105	26	research	research	NOUN
eurjchem-2350	105	27	[	[	X
eurjchem-2350	105	28	43	43	NUM
eurjchem-2350	105	29	]	]	PUNCT
eurjchem-2350	105	30	.	.	PUNCT
eurjchem-2350	106	1	this	this	PRON
eurjchem-2350	106	2	is	be	AUX
eurjchem-2350	106	3	very	very	ADV
eurjchem-2350	106	4	critical	critical	ADJ
eurjchem-2350	106	5	to	to	ADP
eurjchem-2350	106	6	their	their	PRON
eurjchem-2350	106	7	successful	successful	ADJ
eurjchem-2350	106	8	biological	biological	ADJ
eurjchem-2350	106	9	activity	activity	NOUN
eurjchem-2350	106	10	and	and	CCONJ
eurjchem-2350	106	11	bioavailability	bioavailability	NOUN
eurjchem-2350	106	12	when	when	SCONJ
eurjchem-2350	106	13	considering	consider	VERB
eurjchem-2350	106	14	the	the	DET
eurjchem-2350	106	15	administration	administration	NOUN
eurjchem-2350	106	16	of	of	ADP
eurjchem-2350	106	17	drugs	drug	NOUN
eurjchem-2350	106	18	orally	orally	ADV
eurjchem-2350	106	19	or	or	CCONJ
eurjchem-2350	106	20	by	by	ADP
eurjchem-2350	106	21	any	any	DET
eurjchem-2350	106	22	route	route	NOUN
eurjchem-2350	106	23	with	with	ADP
eurjchem-2350	106	24	real	real	ADJ
eurjchem-2350	106	25	therapeutic	therapeutic	ADJ
eurjchem-2350	106	26	potential	potential	NOUN
eurjchem-2350	106	27	[	[	X
eurjchem-2350	106	28	46	46	NUM
eurjchem-2350	106	29	]	]	PUNCT
eurjchem-2350	106	30	.	.	PUNCT
eurjchem-2350	107	1	in	in	ADP
eurjchem-2350	107	2	this	this	DET
eurjchem-2350	107	3	study	study	NOUN
eurjchem-2350	107	4	,	,	PUNCT
eurjchem-2350	107	5	to	to	PART
eurjchem-2350	107	6	pick	pick	VERB
eurjchem-2350	107	7	a	a	DET
eurjchem-2350	107	8	potential	potential	ADJ
eurjchem-2350	107	9	drug	drug	NOUN
eurjchem-2350	107	10	candidate	candidate	NOUN
eurjchem-2350	107	11	,	,	PUNCT
eurjchem-2350	107	12	all	all	DET
eurjchem-2350	107	13	ten	ten	NUM
eurjchem-2350	107	14	quinoline	quinoline	NOUN
eurjchem-2350	107	15	ligands	ligand	NOUN
eurjchem-2350	107	16	were	be	AUX
eurjchem-2350	107	17	screened	screen	VERB
eurjchem-2350	107	18	using	use	VERB
eurjchem-2350	107	19	qikprop	qikprop	NOUN
eurjchem-2350	107	20	,	,	PUNCT
eurjchem-2350	107	21	schrodinger	schrodinger	NOUN
eurjchem-2350	107	22	2011	2011	NUM
eurjchem-2350	107	23	software	software	NOUN
eurjchem-2350	107	24	version	version	NOUN
eurjchem-2350	107	25	3.4	3.4	NUM
eurjchem-2350	107	26	for	for	ADP
eurjchem-2350	107	27	adme	adme	NOUN
eurjchem-2350	107	28	and	and	CCONJ
eurjchem-2350	107	29	toxicity	toxicity	NOUN
eurjchem-2350	107	30	filteration[47	filteration[47	NOUN
eurjchem-2350	107	31	]	]	PUNCT
eurjchem-2350	107	32	.	.	PUNCT
eurjchem-2350	108	1	the	the	DET
eurjchem-2350	108	2	qikprop	qikprop	NOUN
eurjchem-2350	108	3	results	result	NOUN
eurjchem-2350	108	4	of	of	ADP
eurjchem-2350	108	5	adme	adme	NOUN
eurjchem-2350	108	6	were	be	AUX
eurjchem-2350	108	7	found	find	VERB
eurjchem-2350	108	8	within	within	ADP
eurjchem-2350	108	9	the	the	DET
eurjchem-2350	108	10	rule	rule	NOUN
eurjchem-2350	108	11	of	of	ADP
eurjchem-2350	108	12	5	5	NUM
eurjchem-2350	108	13	range	range	NOUN
eurjchem-2350	108	14	without	without	ADP
eurjchem-2350	108	15	violation	violation	NOUN
eurjchem-2350	108	16	.	.	PUNCT
eurjchem-2350	109	1	the	the	DET
eurjchem-2350	109	2	results	result	NOUN
eurjchem-2350	109	3	obtained	obtain	VERB
eurjchem-2350	109	4	from	from	ADP
eurjchem-2350	109	5	this	this	PRON
eurjchem-2350	109	6	indicate	indicate	VERB
eurjchem-2350	109	7	a	a	DET
eurjchem-2350	109	8	value	value	NOUN
eurjchem-2350	109	9	of	of	ADP
eurjchem-2350	109	10	>	>	ADP
eurjchem-2350	109	11	85	85	NUM
eurjchem-2350	109	12	%	%	NOUN
eurjchem-2350	109	13	similarity	similarity	NOUN
eurjchem-2350	109	14	with	with	ADP
eurjchem-2350	109	15	the	the	DET
eurjchem-2350	109	16	known	know	VERB
eurjchem-2350	109	17	drug	drug	NOUN
eurjchem-2350	109	18	molecules	molecule	NOUN
eurjchem-2350	109	19	(	(	PUNCT
eurjchem-2350	109	20	supplementary	supplementary	ADJ
eurjchem-2350	109	21	table	table	NOUN
eurjchem-2350	109	22	1	1	NUM
eurjchem-2350	109	23	)	)	PUNCT
eurjchem-2350	109	24	.	.	PUNCT
eurjchem-2350	110	1	the	the	DET
eurjchem-2350	110	2	admet	admet	PROPN
eurjchem-2350	110	3	predictions	prediction	NOUN
eurjchem-2350	110	4	of	of	ADP
eurjchem-2350	110	5	these	these	DET
eurjchem-2350	110	6	analogues	analogue	NOUN
eurjchem-2350	110	7	are	be	AUX
eurjchem-2350	110	8	asgiven	asgiven	ADJ
eurjchem-2350	110	9	in	in	ADP
eurjchem-2350	110	10	table	table	NOUN
eurjchem-2350	110	11	1	1	NUM
eurjchem-2350	110	12	.	.	PUNCT
eurjchem-2350	111	1	these	these	DET
eurjchem-2350	111	2	indicators	indicator	NOUN
eurjchem-2350	111	3	have	have	AUX
eurjchem-2350	111	4	shown	show	VERB
eurjchem-2350	111	5	very	very	ADV
eurjchem-2350	111	6	good	good	ADJ
eurjchem-2350	111	7	hydrogen	hydrogen	NOUN
eurjchem-2350	111	8	bonding	bonding	NOUN
eurjchem-2350	111	9	ability	ability	NOUN
eurjchem-2350	111	10	and	and	CCONJ
eurjchem-2350	111	11	oral	oral	ADJ
eurjchem-2350	111	12	absorption	absorption	NOUN
eurjchem-2350	111	13	capacity	capacity	NOUN
eurjchem-2350	111	14	for	for	ADP
eurjchem-2350	111	15	all	all	DET
eurjchem-2350	111	16	quinolines	quinoline	NOUN
eurjchem-2350	111	17	and	and	CCONJ
eurjchem-2350	111	18	thus	thus	ADV
eurjchem-2350	111	19	could	could	AUX
eurjchem-2350	111	20	be	be	AUX
eurjchem-2350	111	21	likely	likely	ADJ
eurjchem-2350	111	22	drug	drug	NOUN
eurjchem-2350	111	23	http://prodrg1.dyndns.org/submit.html	http://prodrg1.dyndns.org/submit.html	PROPN
eurjchem-2350	111	24	https://www.pdb.org/	https://www.pdb.org/	ADJ
eurjchem-2350	111	25	http://www.cgl.ucsf.edu/chimera/	http://www.cgl.ucsf.edu/chimera/	NOUN
eurjchem-2350	111	26	kumar	kumar	PROPN
eurjchem-2350	111	27	et	et	PROPN
eurjchem-2350	111	28	al	al	PROPN
eurjchem-2350	111	29	.	.	PUNCT
eurjchem-2350	111	30	/	/	SYM
eurjchem-2350	111	31	european	european	PROPN
eurjchem-2350	111	32	journal	journal	PROPN
eurjchem-2350	111	33	of	of	ADP
eurjchem-2350	111	34	chemistry	chemistry	NOUN
eurjchem-2350	111	35	14	14	NUM
eurjchem-2350	111	36	(	(	PUNCT
eurjchem-2350	111	37	1	1	NUM
eurjchem-2350	111	38	)	)	PUNCT
eurjchem-2350	111	39	(	(	PUNCT
eurjchem-2350	111	40	2023	2023	NUM
eurjchem-2350	111	41	)	)	PUNCT
eurjchem-2350	111	42	30	30	NUM
eurjchem-2350	111	43	-	-	SYM
eurjchem-2350	111	44	38	38	NUM
eurjchem-2350	111	45	33	33	NUM
eurjchem-2350	111	46	2023	2023	NUM
eurjchem-2350	111	47	–	–	PUNCT
eurjchem-2350	111	48	european	european	ADJ
eurjchem-2350	111	49	journal	journal	NOUN
eurjchem-2350	111	50	of	of	ADP
eurjchem-2350	111	51	chemistry	chemistry	NOUN
eurjchem-2350	111	52	–	–	PUNCT
eurjchem-2350	111	53	cc	cc	NOUN
eurjchem-2350	111	54	by	by	ADP
eurjchem-2350	111	55	nc	nc	PROPN
eurjchem-2350	111	56	–	–	PUNCT
eurjchem-2350	111	57	doi	doi	PROPN
eurjchem-2350	111	58	:	:	PUNCT
eurjchem-2350	111	59	10.5155	10.5155	NUM
eurjchem-2350	111	60	/	/	SYM
eurjchem-2350	111	61	eurjchem.14.1.30	eurjchem.14.1.30	PROPN
eurjchem-2350	111	62	-	-	PUNCT
eurjchem-2350	111	63	38.2350	38.2350	NUM
eurjchem-2350	111	64	table	table	NOUN
eurjchem-2350	111	65	2	2	NUM
eurjchem-2350	111	66	.	.	X
eurjchem-2350	111	67	molecular	molecular	ADJ
eurjchem-2350	111	68	interaction	interaction	NOUN
eurjchem-2350	111	69	between	between	ADP
eurjchem-2350	111	70	the	the	DET
eurjchem-2350	111	71	hit	hit	VERB
eurjchem-2350	111	72	quinoline	quinoline	NOUN
eurjchem-2350	111	73	ligands	ligand	NOUN
eurjchem-2350	111	74	and	and	CCONJ
eurjchem-2350	111	75	the	the	DET
eurjchem-2350	111	76	main	main	ADJ
eurjchem-2350	111	77	protease	protease	NOUN
eurjchem-2350	111	78	receptors	receptor	NOUN
eurjchem-2350	111	79	of	of	ADP
eurjchem-2350	111	80	sars	sar	NOUN
eurjchem-2350	111	81	cov-2	cov-2	NOUN
eurjchem-2350	111	82	.	.	PUNCT
eurjchem-2350	112	1	no	no	DET
eurjchem-2350	112	2	compound	compound	NOUN
eurjchem-2350	112	3	binding	bind	VERB
eurjchem-2350	112	4	energy	energy	NOUN
eurjchem-2350	112	5	ligand	ligand	NOUN
eurjchem-2350	112	6	efficiency	efficiency	NOUN
eurjchem-2350	112	7	inhibition	inhibition	NOUN
eurjchem-2350	112	8	constant	constant	ADJ
eurjchem-2350	112	9	(	(	PUNCT
eurjchem-2350	112	10	µm	µm	NOUN
eurjchem-2350	112	11	)	)	PUNCT
eurjchem-2350	112	12	no	no	NOUN
eurjchem-2350	112	13	of	of	ADP
eurjchem-2350	112	14	h	h	NOUN
eurjchem-2350	112	15	aa	aa	NOUN
eurjchem-2350	112	16	in	in	ADP
eurjchem-2350	112	17	the	the	DET
eurjchem-2350	112	18	binding	bind	VERB
eurjchem-2350	112	19	site	site	NOUN
eurjchem-2350	112	20	h	h	NOUN
eurjchem-2350	112	21	-	-	PUNCT
eurjchem-2350	112	22	bond	bond	NOUN
eurjchem-2350	112	23	length	length	NOUN
eurjchem-2350	112	24	in	in	ADP
eurjchem-2350	112	25	å	å	PROPN
eurjchem-2350	112	26	pdb-6lu7	pdb-6lu7	PROPN
eurjchem-2350	112	27	1	1	NUM
eurjchem-2350	112	28	q9	q9	PROPN
eurjchem-2350	112	29	-5.69	-5.69	VERB
eurjchem-2350	112	30	-0.23	-0.23	NUM
eurjchem-2350	112	31	67.79	67.79	NUM
eurjchem-2350	112	32	2	2	NUM
eurjchem-2350	112	33	leu	leu	PROPN
eurjchem-2350	112	34	167	167	NUM
eurjchem-2350	112	35	glu	glu	NOUN
eurjchem-2350	112	36	166	166	NUM
eurjchem-2350	112	37	2.078	2.078	NUM
eurjchem-2350	112	38	2.151	2.151	NUM
eurjchem-2350	112	39	2	2	NUM
eurjchem-2350	112	40	q10	q10	NOUN
eurjchem-2350	112	41	-5.73	-5.73	NUM
eurjchem-2350	112	42	-0.24	-0.24	NUM
eurjchem-2350	112	43	63.35	63.35	NUM
eurjchem-2350	112	44	1	1	NUM
eurjchem-2350	112	45	glu	glu	NOUN
eurjchem-2350	112	46	166	166	NUM
eurjchem-2350	112	47	2.015	2.015	NUM
eurjchem-2350	112	48	3	3	NUM
eurjchem-2350	112	49	hcq	hcq	NOUN
eurjchem-2350	112	50	-3.84	-3.84	PROPN
eurjchem-2350	112	51	-0.17	-0.17	PROPN
eurjchem-2350	112	52	1540	1540	NUM
eurjchem-2350	112	53	1	1	NUM
eurjchem-2350	112	54	phe	phe	NOUN
eurjchem-2350	112	55	140	140	NUM
eurjchem-2350	112	56	2.100	2.100	NUM
eurjchem-2350	112	57	4	4	NUM
eurjchem-2350	112	58	rdv	rdv	NOUN
eurjchem-2350	112	59	1.90	1.90	NUM
eurjchem-2350	112	60	0.05	0.05	NUM
eurjchem-2350	112	61	-3.17	-3.17	NUM
eurjchem-2350	112	62	pdb-6m03	pdb-6m03	NOUN
eurjchem-2350	112	63	1	1	NUM
eurjchem-2350	112	64	q4	q4	PROPN
eurjchem-2350	112	65	-6.96	-6.96	NUM
eurjchem-2350	112	66	-0.29	-0.29	NUM
eurjchem-2350	112	67	7.95	7.95	NUM
eurjchem-2350	112	68	3	3	NUM
eurjchem-2350	112	69	glu	glu	NOUN
eurjchem-2350	112	70	166	166	NUM
eurjchem-2350	112	71	gln	gln	NOUN
eurjchem-2350	112	72	189	189	NUM
eurjchem-2350	112	73	glu	glu	NOUN
eurjchem-2350	112	74	166	166	NUM
eurjchem-2350	112	75	1.760	1.760	NUM
eurjchem-2350	112	76	2.156	2.156	NUM
eurjchem-2350	112	77	1.734	1.734	NUM
eurjchem-2350	112	78	2	2	NUM
eurjchem-2350	112	79	q9	q9	PROPN
eurjchem-2350	112	80	-6.49	-6.49	ADP
eurjchem-2350	112	81	-0.26	-0.26	PROPN
eurjchem-2350	112	82	17.37	17.37	NUM
eurjchem-2350	112	83	2	2	NUM
eurjchem-2350	112	84	gln	gln	NOUN
eurjchem-2350	112	85	189	189	NUM
eurjchem-2350	112	86	glu	glu	NOUN
eurjchem-2350	112	87	166	166	NUM
eurjchem-2350	112	88	1.806	1.806	NUM
eurjchem-2350	112	89	1.885	1.885	NUM
eurjchem-2350	112	90	3	3	NUM
eurjchem-2350	112	91	hcq	hcq	NOUN
eurjchem-2350	112	92	-5.65	-5.65	ADP
eurjchem-2350	112	93	-0.25	-0.25	NUM
eurjchem-2350	112	94	72.30	72.30	NUM
eurjchem-2350	112	95	2	2	NUM
eurjchem-2350	112	96	gly	gly	NOUN
eurjchem-2350	112	97	143	143	NUM
eurjchem-2350	112	98	glu	glu	NOUN
eurjchem-2350	112	99	166	166	NUM
eurjchem-2350	112	100	1.890	1.890	NUM
eurjchem-2350	112	101	2.030	2.030	NUM
eurjchem-2350	112	102	4	4	NUM
eurjchem-2350	112	103	rdv	rdv	NOUN
eurjchem-2350	112	104	-5.33	-5.33	NUM
eurjchem-2350	112	105	-0.13	-0.13	NUM
eurjchem-2350	112	106	124.88	124.88	NUM
eurjchem-2350	112	107	1	1	NUM
eurjchem-2350	112	108	glu166	glu166	PROPN
eurjchem-2350	112	109	1.945	1.945	NUM
eurjchem-2350	112	110	pdb-6w63	pdb-6w63	PROPN
eurjchem-2350	112	111	1	1	NUM
eurjchem-2350	112	112	q9	q9	PROPN
eurjchem-2350	112	113	-6.97	-6.97	NUM
eurjchem-2350	112	114	-0.28	-0.28	NUM
eurjchem-2350	112	115	7.76	7.76	NUM
eurjchem-2350	112	116	2	2	NUM
eurjchem-2350	112	117	ser	ser	NOUN
eurjchem-2350	112	118	46	46	NUM
eurjchem-2350	112	119	ser	ser	NOUN
eurjchem-2350	112	120	46	46	NUM
eurjchem-2350	112	121	1.749	1.749	NUM
eurjchem-2350	112	122	1.959	1.959	NUM
eurjchem-2350	112	123	2	2	NUM
eurjchem-2350	112	124	q10	q10	PROPN
eurjchem-2350	112	125	-5.94	-5.94	NUM
eurjchem-2350	112	126	-0.25	-0.25	NUM
eurjchem-2350	112	127	44.52	44.52	NUM
eurjchem-2350	112	128	2	2	NUM
eurjchem-2350	112	129	thr	thr	PROPN
eurjchem-2350	112	130	24	24	NUM
eurjchem-2350	112	131	ser	ser	NOUN
eurjchem-2350	112	132	46	46	NUM
eurjchem-2350	112	133	1.939	1.939	NUM
eurjchem-2350	112	134	1.872	1.872	NUM
eurjchem-2350	112	135	3	3	NUM
eurjchem-2350	112	136	hcq	hcq	NOUN
eurjchem-2350	112	137	-4.49	-4.49	NUM
eurjchem-2350	112	138	-0.20	-0.20	NUM
eurjchem-2350	113	1	514.35	514.35	NUM
eurjchem-2350	113	2	1	1	NUM
eurjchem-2350	113	3	thr25	thr25	PROPN
eurjchem-2350	113	4	1.847	1.847	NUM
eurjchem-2350	113	5	4	4	NUM
eurjchem-2350	113	6	rdv	rdv	NOUN
eurjchem-2350	113	7	-5.05	-5.05	NOUN
eurjchem-2350	113	8	-0.12	-0.12	NUM
eurjchem-2350	113	9	198.00	198.00	NUM
eurjchem-2350	113	10	pdb-6y84	pdb-6y84	NOUN
eurjchem-2350	113	11	1	1	NUM
eurjchem-2350	113	12	q8	q8	PROPN
eurjchem-2350	113	13	-9.87	-9.87	VERB
eurjchem-2350	113	14	-0.41	-0.41	NOUN
eurjchem-2350	113	15	0.058	0.058	NUM
eurjchem-2350	113	16	2	2	NUM
eurjchem-2350	113	17	phe	phe	NOUN
eurjchem-2350	113	18	140	140	NUM
eurjchem-2350	113	19	glu	glu	NOUN
eurjchem-2350	113	20	166	166	NUM
eurjchem-2350	113	21	1.900	1.900	NUM
eurjchem-2350	113	22	1.974	1.974	NUM
eurjchem-2350	113	23	2	2	NUM
eurjchem-2350	113	24	q9	q9	NOUN
eurjchem-2350	113	25	-8.78	-8.78	NOUN
eurjchem-2350	113	26	-0.35	-0.35	NUM
eurjchem-2350	113	27	0.36	0.36	NUM
eurjchem-2350	113	28	2	2	NUM
eurjchem-2350	113	29	glu	glu	NOUN
eurjchem-2350	113	30	166	166	NUM
eurjchem-2350	113	31	phe	phe	NOUN
eurjchem-2350	113	32	140	140	NUM
eurjchem-2350	113	33	1.744	1.744	NUM
eurjchem-2350	113	34	1.978	1.978	NUM
eurjchem-2350	113	35	3	3	NUM
eurjchem-2350	113	36	hcq	hcq	NOUN
eurjchem-2350	113	37	-6.06	-6.06	CCONJ
eurjchem-2350	113	38	-0.26	-0.26	PROPN
eurjchem-2350	113	39	35.93	35.93	NUM
eurjchem-2350	113	40	2	2	NUM
eurjchem-2350	113	41	gly	gly	NOUN
eurjchem-2350	113	42	143	143	NUM
eurjchem-2350	113	43	glu	glu	NOUN
eurjchem-2350	113	44	166	166	NUM
eurjchem-2350	113	45	2.107	2.107	NUM
eurjchem-2350	113	46	2.029	2.029	NUM
eurjchem-2350	113	47	4	4	NUM
eurjchem-2350	113	48	rdv	rdv	NOUN
eurjchem-2350	113	49	-7.22	-7.22	NOUN
eurjchem-2350	113	50	-0.17	-0.17	NOUN
eurjchem-2350	113	51	5.12	5.12	NUM
eurjchem-2350	113	52	1	1	NUM
eurjchem-2350	113	53	glu166	glu166	PROPN
eurjchem-2350	113	54	1.875	1.875	NUM
eurjchem-2350	113	55	pdb-6yb7	pdb-6yb7	NOUN
eurjchem-2350	113	56	1	1	NUM
eurjchem-2350	113	57	q8	q8	PROPN
eurjchem-2350	113	58	-6.16	-6.16	NUM
eurjchem-2350	113	59	-0.26	-0.26	PROPN
eurjchem-2350	113	60	30.52	30.52	NUM
eurjchem-2350	113	61	1	1	NUM
eurjchem-2350	113	62	his	his	PRON
eurjchem-2350	113	63	41	41	NUM
eurjchem-2350	113	64	2.184	2.184	NUM
eurjchem-2350	113	65	2	2	NUM
eurjchem-2350	113	66	q9	q9	PROPN
eurjchem-2350	113	67	-6.88	-6.88	NUM
eurjchem-2350	113	68	-0.28	-0.28	NUM
eurjchem-2350	113	69	9.09	9.09	NUM
eurjchem-2350	113	70	3	3	NUM
eurjchem-2350	113	71	thr	thr	INTJ
eurjchem-2350	114	1	24	24	NUM
eurjchem-2350	115	1	thr	thr	INTJ
eurjchem-2350	115	2	24	24	NUM
eurjchem-2350	116	1	thr	thr	NOUN
eurjchem-2350	116	2	26	26	NUM
eurjchem-2350	117	1	2.127	2.127	NUM
eurjchem-2350	117	2	2.073	2.073	NUM
eurjchem-2350	117	3	1.837	1.837	NUM
eurjchem-2350	117	4	3	3	NUM
eurjchem-2350	117	5	q10	q10	PROPN
eurjchem-2350	117	6	-6.36	-6.36	PROPN
eurjchem-2350	117	7	-0.27	-0.27	PROPN
eurjchem-2350	117	8	21.71	21.71	NUM
eurjchem-2350	117	9	3	3	NUM
eurjchem-2350	117	10	thr	thr	PROPN
eurjchem-2350	117	11	24	24	NUM
eurjchem-2350	117	12	thr	thr	INTJ
eurjchem-2350	117	13	24	24	NUM
eurjchem-2350	118	1	thr	thr	PROPN
eurjchem-2350	118	2	26	26	NUM
eurjchem-2350	118	3	2.172	2.172	NUM
eurjchem-2350	118	4	1.791	1.791	NUM
eurjchem-2350	118	5	2.096	2.096	NUM
eurjchem-2350	118	6	4	4	NUM
eurjchem-2350	118	7	hcq	hcq	NOUN
eurjchem-2350	118	8	-4.88	-4.88	PROPN
eurjchem-2350	118	9	-0.21	-0.21	NUM
eurjchem-2350	118	10	264.33	264.33	NUM
eurjchem-2350	118	11	2	2	NUM
eurjchem-2350	118	12	gly	gly	NOUN
eurjchem-2350	118	13	143	143	NUM
eurjchem-2350	118	14	asn	asn	PROPN
eurjchem-2350	118	15	119	119	NUM
eurjchem-2350	118	16	1.838	1.838	NUM
eurjchem-2350	118	17	5	5	NUM
eurjchem-2350	118	18	rdv	rdv	NOUN
eurjchem-2350	118	19	-5.01	-5.01	NOUN
eurjchem-2350	118	20	-0.12	-0.12	NUM
eurjchem-2350	118	21	213.81	213.81	NUM
eurjchem-2350	118	22	3	3	NUM
eurjchem-2350	118	23	thr24	thr24	PROPN
eurjchem-2350	118	24	thr26	thr26	NOUN
eurjchem-2350	118	25	gly143	gly143	VERB
eurjchem-2350	118	26	1.933	1.933	NUM
eurjchem-2350	118	27	1.959	1.959	NUM
eurjchem-2350	118	28	1.725	1.725	NUM
eurjchem-2350	118	29	candidates	candidate	NOUN
eurjchem-2350	118	30	which	which	PRON
eurjchem-2350	118	31	are	be	AUX
eurjchem-2350	118	32	also	also	ADV
eurjchem-2350	118	33	substantiated	substantiate	VERB
eurjchem-2350	118	34	by	by	ADP
eurjchem-2350	118	35	the	the	DET
eurjchem-2350	118	36	star	star	NOUN
eurjchem-2350	118	37	value	value	NOUN
eurjchem-2350	118	38	of	of	ADP
eurjchem-2350	118	39	zero	zero	NUM
eurjchem-2350	118	40	.	.	PUNCT
eurjchem-2350	119	1	furthermore	furthermore	ADV
eurjchem-2350	119	2	,	,	PUNCT
eurjchem-2350	119	3	the	the	DET
eurjchem-2350	119	4	number	number	NOUN
eurjchem-2350	119	5	of	of	ADP
eurjchem-2350	119	6	violations	violation	NOUN
eurjchem-2350	119	7	(	(	PUNCT
eurjchem-2350	119	8	lipinski	lipinski	PROPN
eurjchem-2350	119	9	’s	’s	PART
eurjchem-2350	119	10	rule	rule	NOUN
eurjchem-2350	119	11	of	of	ADP
eurjchem-2350	119	12	five	five	NUM
eurjchem-2350	119	13	and	and	CCONJ
eurjchem-2350	119	14	jorgensen	jorgensen	PROPN
eurjchem-2350	119	15	’s	’s	PART
eurjchem-2350	119	16	rule	rule	NOUN
eurjchem-2350	119	17	of	of	ADP
eurjchem-2350	119	18	three	three	NUM
eurjchem-2350	119	19	)	)	PUNCT
eurjchem-2350	119	20	were	be	AUX
eurjchem-2350	119	21	found	find	VERB
eurjchem-2350	119	22	to	to	ADP
eurjchem-2350	119	23	zero	zero	NUM
eurjchem-2350	119	24	for	for	ADP
eurjchem-2350	119	25	all	all	DET
eurjchem-2350	119	26	these	these	DET
eurjchem-2350	119	27	molecules	molecule	NOUN
eurjchem-2350	119	28	.	.	PUNCT
eurjchem-2350	120	1	therefore	therefore	ADV
eurjchem-2350	120	2	,	,	PUNCT
eurjchem-2350	120	3	most	most	ADJ
eurjchem-2350	120	4	of	of	ADP
eurjchem-2350	120	5	the	the	DET
eurjchem-2350	120	6	predicted	predict	VERB
eurjchem-2350	120	7	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-2350	120	8	parameters	parameter	NOUN
eurjchem-2350	120	9	of	of	ADP
eurjchem-2350	120	10	these	these	DET
eurjchem-2350	120	11	ten	ten	NUM
eurjchem-2350	120	12	quinoline	quinoline	NOUN
eurjchem-2350	120	13	derivatives	derivative	NOUN
eurjchem-2350	120	14	were	be	AUX
eurjchem-2350	120	15	found	find	VERB
eurjchem-2350	120	16	to	to	PART
eurjchem-2350	120	17	be	be	AUX
eurjchem-2350	120	18	within	within	ADP
eurjchem-2350	120	19	the	the	DET
eurjchem-2350	120	20	range	range	NOUN
eurjchem-2350	120	21	or	or	CCONJ
eurjchem-2350	120	22	recommended	recommend	VERB
eurjchem-2350	120	23	values	value	NOUN
eurjchem-2350	120	24	(	(	PUNCT
eurjchem-2350	120	25	table	table	NOUN
eurjchem-2350	120	26	1	1	NUM
eurjchem-2350	120	27	)	)	PUNCT
eurjchem-2350	120	28	to	to	PART
eurjchem-2350	120	29	become	become	VERB
eurjchem-2350	120	30	a	a	DET
eurjchem-2350	120	31	potent	potent	ADJ
eurjchem-2350	120	32	inhibitor	inhibitor	NOUN
eurjchem-2350	120	33	drug	drug	NOUN
eurjchem-2350	120	34	molecule	molecule	NOUN
eurjchem-2350	120	35	.	.	PUNCT
eurjchem-2350	121	1	a	a	DET
eurjchem-2350	121	2	polar	polar	ADJ
eurjchem-2350	121	3	surface	surface	NOUN
eurjchem-2350	121	4	area	area	NOUN
eurjchem-2350	121	5	(	(	PUNCT
eurjchem-2350	121	6	psa	psa	NOUN
eurjchem-2350	121	7	)	)	PUNCT
eurjchem-2350	121	8	of	of	ADP
eurjchem-2350	121	9	less	less	ADJ
eurjchem-2350	121	10	than	than	ADP
eurjchem-2350	121	11	90	90	NUM
eurjchem-2350	121	12	angstroms	angstrom	NOUN
eurjchem-2350	121	13	is	be	AUX
eurjchem-2350	121	14	usually	usually	ADV
eurjchem-2350	121	15	required	require	VERB
eurjchem-2350	121	16	for	for	ADP
eurjchem-2350	121	17	drug	drug	NOUN
eurjchem-2350	121	18	candidates	candidate	NOUN
eurjchem-2350	121	19	to	to	PART
eurjchem-2350	121	20	penetrate	penetrate	VERB
eurjchem-2350	121	21	the	the	DET
eurjchem-2350	121	22	bloodbrain	bloodbrain	NOUN
eurjchem-2350	121	23	barrier	barrier	NOUN
eurjchem-2350	121	24	(	(	PUNCT
eurjchem-2350	121	25	bbb	bbb	NOUN
eurjchem-2350	121	26	)	)	PUNCT
eurjchem-2350	121	27	and	and	CCONJ
eurjchem-2350	121	28	thus	thus	ADV
eurjchem-2350	121	29	act	act	VERB
eurjchem-2350	121	30	on	on	ADP
eurjchem-2350	121	31	receptors	receptor	NOUN
eurjchem-2350	121	32	in	in	ADP
eurjchem-2350	121	33	the	the	DET
eurjchem-2350	121	34	central	central	ADJ
eurjchem-2350	121	35	nervous	nervous	ADJ
eurjchem-2350	121	36	system	system	NOUN
eurjchem-2350	121	37	.	.	PUNCT
eurjchem-2350	122	1	log	log	NOUN
eurjchem-2350	122	2	bb	bb	PROPN
eurjchem-2350	122	3	is	be	AUX
eurjchem-2350	122	4	the	the	DET
eurjchem-2350	122	5	most	most	ADV
eurjchem-2350	122	6	familiar	familiar	ADJ
eurjchem-2350	122	7	numeric	numeric	ADJ
eurjchem-2350	122	8	value	value	NOUN
eurjchem-2350	122	9	that	that	PRON
eurjchem-2350	122	10	describes	describe	VERB
eurjchem-2350	122	11	permeability	permeability	NOUN
eurjchem-2350	122	12	through	through	ADP
eurjchem-2350	122	13	the	the	DET
eurjchem-2350	122	14	bbb	bbb	NOUN
eurjchem-2350	123	1	[	[	X
eurjchem-2350	123	2	48	48	NUM
eurjchem-2350	123	3	]	]	PUNCT
eurjchem-2350	123	4	.	.	PUNCT
eurjchem-2350	124	1	most	most	ADJ
eurjchem-2350	124	2	drugs	drug	NOUN
eurjchem-2350	124	3	are	be	AUX
eurjchem-2350	124	4	not	not	PART
eurjchem-2350	124	5	especially	especially	ADV
eurjchem-2350	124	6	permeable	permeable	ADJ
eurjchem-2350	124	7	through	through	ADP
eurjchem-2350	124	8	caco-2	caco-2	NUM
eurjchem-2350	124	9	cells	cell	NOUN
eurjchem-2350	124	10	[	[	X
eurjchem-2350	124	11	49	49	NUM
eurjchem-2350	124	12	]	]	PUNCT
eurjchem-2350	124	13	.	.	PUNCT
eurjchem-2350	125	1	the	the	DET
eurjchem-2350	125	2	predicted	predict	VERB
eurjchem-2350	125	3	caco-2	caco-2	NUM
eurjchem-2350	125	4	permeability	permeability	NOUN
eurjchem-2350	125	5	for	for	ADP
eurjchem-2350	125	6	these	these	DET
eurjchem-2350	125	7	ten	ten	NUM
eurjchem-2350	125	8	quinolines	quinoline	NOUN
eurjchem-2350	125	9	were	be	AUX
eurjchem-2350	125	10	found	find	VERB
eurjchem-2350	125	11	to	to	PART
eurjchem-2350	125	12	be	be	AUX
eurjchem-2350	125	13	high	high	ADJ
eurjchem-2350	125	14	for	for	ADP
eurjchem-2350	125	15	human	human	ADJ
eurjchem-2350	125	16	intestinal	intestinal	ADJ
eurjchem-2350	125	17	absorption	absorption	NOUN
eurjchem-2350	125	18	(	(	PUNCT
eurjchem-2350	125	19	hia	hia	PROPN
eurjchem-2350	125	20	≥	≥	NUM
eurjchem-2350	125	21	80	80	NUM
eurjchem-2350	125	22	)	)	PUNCT
eurjchem-2350	125	23	,	,	PUNCT
eurjchem-2350	125	24	which	which	PRON
eurjchem-2350	125	25	authenticates	authenticate	VERB
eurjchem-2350	125	26	the	the	DET
eurjchem-2350	125	27	higher	high	ADJ
eurjchem-2350	125	28	oral	oral	ADJ
eurjchem-2350	125	29	absorption	absorption	NOUN
eurjchem-2350	125	30	or	or	CCONJ
eurjchem-2350	125	31	membrane	membrane	NOUN
eurjchem-2350	125	32	permeability	permeability	NOUN
eurjchem-2350	125	33	nature	nature	NOUN
eurjchem-2350	125	34	of	of	ADP
eurjchem-2350	125	35	the	the	DET
eurjchem-2350	125	36	quinolines	quinoline	NOUN
eurjchem-2350	125	37	.	.	PUNCT
eurjchem-2350	126	1	the	the	DET
eurjchem-2350	126	2	admet	admet	PROPN
eurjchem-2350	126	3	prediction	prediction	NOUN
eurjchem-2350	126	4	result	result	NOUN
eurjchem-2350	126	5	was	be	AUX
eurjchem-2350	126	6	validated	validate	VERB
eurjchem-2350	126	7	with	with	ADP
eurjchem-2350	126	8	the	the	DET
eurjchem-2350	126	9	docking	docking	NOUN
eurjchem-2350	126	10	study	study	NOUN
eurjchem-2350	126	11	results	result	NOUN
eurjchem-2350	126	12	,	,	PUNCT
eurjchem-2350	126	13	and	and	CCONJ
eurjchem-2350	126	14	these	these	DET
eurjchem-2350	126	15	quinolines	quinoline	NOUN
eurjchem-2350	126	16	were	be	AUX
eurjchem-2350	126	17	found	find	VERB
eurjchem-2350	126	18	to	to	PART
eurjchem-2350	126	19	be	be	AUX
eurjchem-2350	126	20	nontoxic	nontoxic	ADJ
eurjchem-2350	126	21	,	,	PUNCT
eurjchem-2350	126	22	absorb	absorb	VERB
eurjchem-2350	126	23	in	in	ADP
eurjchem-2350	126	24	the	the	DET
eurjchem-2350	126	25	human	human	ADJ
eurjchem-2350	126	26	intestine	intestine	NOUN
eurjchem-2350	126	27	,	,	PUNCT
eurjchem-2350	126	28	non	non	ADJ
eurjchem-2350	126	29	-	-	ADJ
eurjchem-2350	126	30	carcinogenic	carcinogenic	ADJ
eurjchem-2350	126	31	,	,	PUNCT
eurjchem-2350	126	32	have	have	VERB
eurjchem-2350	126	33	caco-2	caco-2	NUM
eurjchem-2350	126	34	permeability	permeability	NOUN
eurjchem-2350	126	35	,	,	PUNCT
eurjchem-2350	126	36	and	and	CCONJ
eurjchem-2350	126	37	do	do	AUX
eurjchem-2350	126	38	not	not	PART
eurjchem-2350	126	39	violate	violate	VERB
eurjchem-2350	126	40	the	the	DET
eurjchem-2350	126	41	lipinski	lipinski	PROPN
eurjchem-2350	126	42	's	's	PART
eurjchem-2350	126	43	rule	rule	NOUN
eurjchem-2350	126	44	of	of	ADP
eurjchem-2350	126	45	three	three	NUM
eurjchem-2350	126	46	and	and	CCONJ
eurjchem-2350	126	47	five	five	NUM
eurjchem-2350	126	48	,	,	PUNCT
eurjchem-2350	126	49	suggesting	suggest	VERB
eurjchem-2350	126	50	their	their	PRON
eurjchem-2350	126	51	significant	significant	ADJ
eurjchem-2350	126	52	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-2350	126	53	properties	property	NOUN
eurjchem-2350	126	54	.	.	PUNCT
eurjchem-2350	127	1	3.2	3.2	NUM
eurjchem-2350	127	2	.	.	X
eurjchem-2350	127	3	molecular	molecular	ADJ
eurjchem-2350	127	4	docking	docking	NOUN
eurjchem-2350	127	5	studies	study	NOUN
eurjchem-2350	127	6	of	of	ADP
eurjchem-2350	127	7	quinolines	quinoline	NOUN
eurjchem-2350	127	8	to	to	PART
eurjchem-2350	127	9	understand	understand	VERB
eurjchem-2350	127	10	the	the	DET
eurjchem-2350	127	11	binding	bind	VERB
eurjchem-2350	127	12	interaction	interaction	NOUN
eurjchem-2350	127	13	of	of	ADP
eurjchem-2350	127	14	these	these	DET
eurjchem-2350	127	15	molecules	molecule	NOUN
eurjchem-2350	127	16	with	with	ADP
eurjchem-2350	127	17	covid-19	covid-19	PROPN
eurjchem-2350	127	18	virus	virus	NOUN
eurjchem-2350	127	19	mpro	mpro	ADJ
eurjchem-2350	127	20	,	,	PUNCT
eurjchem-2350	127	21	molecular	molecular	ADJ
eurjchem-2350	127	22	docking	docking	NOUN
eurjchem-2350	127	23	studies	study	NOUN
eurjchem-2350	127	24	were	be	AUX
eurjchem-2350	127	25	used	use	VERB
eurjchem-2350	127	26	.	.	PUNCT
eurjchem-2350	128	1	in	in	ADP
eurjchem-2350	128	2	viral	viral	ADJ
eurjchem-2350	128	3	gene	gene	NOUN
eurjchem-2350	128	4	expression	expression	NOUN
eurjchem-2350	128	5	and	and	CCONJ
eurjchem-2350	128	6	replication	replication	NOUN
eurjchem-2350	128	7	,	,	PUNCT
eurjchem-2350	128	8	mpros	mpro	NOUN
eurjchem-2350	128	9	are	be	AUX
eurjchem-2350	128	10	the	the	DET
eurjchem-2350	128	11	main	main	ADJ
eurjchem-2350	128	12	enzymes	enzyme	NOUN
eurjchem-2350	128	13	[	[	X
eurjchem-2350	128	14	50	50	NUM
eurjchem-2350	128	15	]	]	PUNCT
eurjchem-2350	128	16	.	.	PUNCT
eurjchem-2350	129	1	molecular	molecular	ADJ
eurjchem-2350	129	2	docking	docking	NOUN
eurjchem-2350	129	3	studies	study	NOUN
eurjchem-2350	129	4	were	be	AUX
eurjchem-2350	129	5	performed	perform	VERB
eurjchem-2350	129	6	to	to	PART
eurjchem-2350	129	7	investigate	investigate	VERB
eurjchem-2350	129	8	the	the	DET
eurjchem-2350	129	9	binding	bind	VERB
eurjchem-2350	129	10	efficiency	efficiency	NOUN
eurjchem-2350	129	11	at	at	ADP
eurjchem-2350	129	12	the	the	DET
eurjchem-2350	129	13	active	active	ADJ
eurjchem-2350	129	14	sites	site	NOUN
eurjchem-2350	129	15	of	of	ADP
eurjchem-2350	129	16	five	five	NUM
eurjchem-2350	129	17	sarscov-2	sarscov-2	NUM
eurjchem-2350	129	18	mpro	mpro	ADJ
eurjchem-2350	129	19	(	(	PUNCT
eurjchem-2350	129	20	pdb	pdb	PROPN
eurjchem-2350	129	21	i	i	PROPN
eurjchem-2350	129	22	d	d	PROPN
eurjchem-2350	129	23	:	:	PUNCT
eurjchem-2350	129	24	6lu7	6lu7	NUM
eurjchem-2350	129	25	,	,	PUNCT
eurjchem-2350	129	26	6w63	6w63	NUM
eurjchem-2350	129	27	,	,	PUNCT
eurjchem-2350	129	28	6m03	6m03	NOUN
eurjchem-2350	129	29	,	,	PUNCT
eurjchem-2350	129	30	6yb7	6yb7	NUM
eurjchem-2350	129	31	,	,	PUNCT
eurjchem-2350	129	32	and	and	CCONJ
eurjchem-2350	129	33	6y84	6y84	NOUN
eurjchem-2350	129	34	)	)	PUNCT
eurjchem-2350	129	35	.	.	PUNCT
eurjchem-2350	130	1	the	the	DET
eurjchem-2350	130	2	results	result	NOUN
eurjchem-2350	130	3	of	of	ADP
eurjchem-2350	130	4	the	the	DET
eurjchem-2350	130	5	docking	docking	NOUN
eurjchem-2350	130	6	analysis	analysis	NOUN
eurjchem-2350	130	7	showed	show	VERB
eurjchem-2350	130	8	that	that	SCONJ
eurjchem-2350	130	9	the	the	DET
eurjchem-2350	130	10	binding	bind	VERB
eurjchem-2350	130	11	pocket	pocket	NOUN
eurjchem-2350	130	12	of	of	ADP
eurjchem-2350	130	13	these	these	DET
eurjchem-2350	130	14	covid-19	covid-19	PROPN
eurjchem-2350	130	15	proteases	protease	NOUN
eurjchem-2350	130	16	involves	involve	VERB
eurjchem-2350	130	17	various	various	ADJ
eurjchem-2350	130	18	amino	amino	NOUN
eurjchem-2350	130	19	acid	acid	NOUN
eurjchem-2350	130	20	residues	residue	NOUN
eurjchem-2350	130	21	such	such	ADJ
eurjchem-2350	130	22	as	as	ADP
eurjchem-2350	130	23	ser46	ser46	ADJ
eurjchem-2350	130	24	and	and	CCONJ
eurjchem-2350	130	25	thr25	thr25	ADV
eurjchem-2350	130	26	in	in	ADP
eurjchem-2350	130	27	6w63	6w63	NUM
eurjchem-2350	130	28	;	;	PUNCT
eurjchem-2350	130	29	glu166	glu166	PROPN
eurjchem-2350	130	30	,	,	PUNCT
eurjchem-2350	130	31	gly189	gly189	PROPN
eurjchem-2350	130	32	,	,	PUNCT
eurjchem-2350	130	33	asn142	asn142	NOUN
eurjchem-2350	130	34	,	,	PUNCT
eurjchem-2350	130	35	and	and	CCONJ
eurjchem-2350	130	36	gly143	gly143	VERB
eurjchem-2350	130	37	in	in	ADP
eurjchem-2350	130	38	6m03	6m03	NOUN
eurjchem-2350	130	39	;	;	PUNCT
eurjchem-2350	130	40	phe140	phe140	ADJ
eurjchem-2350	130	41	,	,	PUNCT
eurjchem-2350	130	42	leu167	leu167	PROPN
eurjchem-2350	130	43	,	,	PUNCT
eurjchem-2350	130	44	and	and	CCONJ
eurjchem-2350	130	45	glu166	glu166	NOUN
eurjchem-2350	130	46	in	in	ADP
eurjchem-2350	130	47	6lu7	6lu7	NUM
eurjchem-2350	130	48	;	;	PUNCT
eurjchem-2350	130	49	glu166	glu166	PROPN
eurjchem-2350	130	50	,	,	PUNCT
eurjchem-2350	130	51	phe140	phe140	PROPN
eurjchem-2350	130	52	,	,	PUNCT
eurjchem-2350	130	53	and	and	CCONJ
eurjchem-2350	130	54	gly143	gly143	VERB
eurjchem-2350	130	55	in	in	ADP
eurjchem-2350	130	56	6y84[51	6y84[51	NUM
eurjchem-2350	130	57	]	]	PUNCT
eurjchem-2350	130	58	and	and	CCONJ
eurjchem-2350	130	59	cys44	cys44	PROPN
eurjchem-2350	130	60	,	,	PUNCT
eurjchem-2350	130	61	thr24	thr24	PROPN
eurjchem-2350	130	62	,	,	PUNCT
eurjchem-2350	130	63	thr26	thr26	NOUN
eurjchem-2350	130	64	,	,	PUNCT
eurjchem-2350	130	65	his41	his41	PROPN
eurjchem-2350	130	66	,	,	PUNCT
eurjchem-2350	130	67	gly143	gly143	NOUN
eurjchem-2350	130	68	,	,	PUNCT
eurjchem-2350	130	69	and	and	CCONJ
eurjchem-2350	130	70	asn119	asn119	PROPN
eurjchem-2350	130	71	in	in	ADP
eurjchem-2350	130	72	6yb7	6yb7	NUM
eurjchem-2350	130	73	.	.	PUNCT
eurjchem-2350	131	1	the	the	DET
eurjchem-2350	131	2	important	important	ADJ
eurjchem-2350	131	3	hydrogen	hydrogen	NOUN
eurjchem-2350	131	4	bond	bond	NOUN
eurjchem-2350	131	5	forming	form	VERB
eurjchem-2350	131	6	amino	amino	NOUN
eurjchem-2350	131	7	acid	acid	NOUN
eurjchem-2350	131	8	residues	residue	NOUN
eurjchem-2350	131	9	are	be	AUX
eurjchem-2350	131	10	glu166	glu166	NOUN
eurjchem-2350	131	11	,	,	PUNCT
eurjchem-2350	131	12	phe140	phe140	ADJ
eurjchem-2350	131	13	and	and	CCONJ
eurjchem-2350	131	14	asn142	asn142	PROPN
eurjchem-2350	131	15	.	.	PUNCT
eurjchem-2350	132	1	it	it	PRON
eurjchem-2350	132	2	has	have	AUX
eurjchem-2350	132	3	already	already	ADV
eurjchem-2350	132	4	been	be	AUX
eurjchem-2350	132	5	shown	show	VERB
eurjchem-2350	132	6	that	that	SCONJ
eurjchem-2350	132	7	his41	his41	PROPN
eurjchem-2350	132	8	,	,	PUNCT
eurjchem-2350	132	9	his163	his163	NOUN
eurjchem-2350	132	10	,	,	PUNCT
eurjchem-2350	132	11	his164	his164	NOUN
eurjchem-2350	132	12	,	,	PUNCT
eurjchem-2350	132	13	and	and	CCONJ
eurjchem-2350	132	14	glu166	glu166	NOUN
eurjchem-2350	132	15	are	be	AUX
eurjchem-2350	132	16	the	the	DET
eurjchem-2350	132	17	most	most	ADV
eurjchem-2350	132	18	important	important	ADJ
eurjchem-2350	132	19	amino	amino	NOUN
eurjchem-2350	132	20	acid	acid	NOUN
eurjchem-2350	132	21	residues	residue	NOUN
eurjchem-2350	132	22	of	of	ADP
eurjchem-2350	132	23	covid-19	covid-19	PROPN
eurjchem-2350	132	24	mpro	mpro	ADJ
eurjchem-2350	132	25	in	in	ADP
eurjchem-2350	132	26	the	the	DET
eurjchem-2350	132	27	interaction	interaction	NOUN
eurjchem-2350	132	28	with	with	ADP
eurjchem-2350	132	29	the	the	DET
eurjchem-2350	132	30	inhibitor	inhibitor	NOUN
eurjchem-2350	132	31	in	in	ADP
eurjchem-2350	132	32	the	the	DET
eurjchem-2350	132	33	case	case	NOUN
eurjchem-2350	132	34	of	of	ADP
eurjchem-2350	132	35	the	the	DET
eurjchem-2350	132	36	6lu7	6lu7	NUM
eurjchem-2350	132	37	receptor	receptor	NOUN
eurjchem-2350	132	38	using	use	VERB
eurjchem-2350	132	39	fmo	fmo	NOUN
eurjchem-2350	132	40	analysis	analysis	NOUN
eurjchem-2350	132	41	[	[	X
eurjchem-2350	132	42	52	52	NUM
eurjchem-2350	132	43	]	]	PUNCT
eurjchem-2350	132	44	.	.	PUNCT
eurjchem-2350	133	1	in	in	ADP
eurjchem-2350	133	2	this	this	DET
eurjchem-2350	133	3	study	study	NOUN
eurjchem-2350	133	4	,	,	PUNCT
eurjchem-2350	133	5	the	the	DET
eurjchem-2350	133	6	tested	test	VERB
eurjchem-2350	133	7	quinoline	quinoline	NOUN
eurjchem-2350	133	8	ligands	ligand	NOUN
eurjchem-2350	133	9	were	be	AUX
eurjchem-2350	133	10	also	also	ADV
eurjchem-2350	133	11	found	find	VERB
eurjchem-2350	133	12	to	to	PART
eurjchem-2350	133	13	commonly	commonly	ADV
eurjchem-2350	133	14	bind	bind	VERB
eurjchem-2350	133	15	to	to	ADP
eurjchem-2350	133	16	glu166	glu166	NOUN
eurjchem-2350	133	17	to	to	PART
eurjchem-2350	133	18	form	form	VERB
eurjchem-2350	133	19	a	a	DET
eurjchem-2350	133	20	hydrogen	hydrogen	NOUN
eurjchem-2350	133	21	bond	bond	NOUN
eurjchem-2350	133	22	within	within	ADP
eurjchem-2350	133	23	a	a	DET
eurjchem-2350	133	24	2.3	2.3	NUM
eurjchem-2350	133	25	å	å	PROPN
eurjchem-2350	133	26	distance	distance	NOUN
eurjchem-2350	133	27	with	with	ADP
eurjchem-2350	133	28	the	the	DET
eurjchem-2350	133	29	receptors	receptor	NOUN
eurjchem-2350	133	30	6lu7	6lu7	NUM
eurjchem-2350	133	31	,	,	PUNCT
eurjchem-2350	133	32	6y84	6y84	NOUN
eurjchem-2350	133	33	and	and	CCONJ
eurjchem-2350	133	34	6m03	6m03	NOUN
eurjchem-2350	133	35	(	(	PUNCT
eurjchem-2350	133	36	table	table	NOUN
eurjchem-2350	133	37	2	2	NUM
eurjchem-2350	133	38	)	)	PUNCT
eurjchem-2350	133	39	.	.	PUNCT
eurjchem-2350	134	1	recently	recently	ADV
eurjchem-2350	134	2	,	,	PUNCT
eurjchem-2350	134	3	it	it	PRON
eurjchem-2350	134	4	has	have	AUX
eurjchem-2350	134	5	been	be	AUX
eurjchem-2350	134	6	reported	report	VERB
eurjchem-2350	134	7	that	that	SCONJ
eurjchem-2350	134	8	quinoline	quinoline	NOUN
eurjchem-2350	134	9	1	1	NUM
eurjchem-2350	134	10	,	,	PUNCT
eurjchem-2350	134	11	2	2	NUM
eurjchem-2350	134	12	,	,	PUNCT
eurjchem-2350	134	13	3	3	NUM
eurjchem-2350	134	14	,	,	PUNCT
eurjchem-2350	134	15	4tetrahydro-1-[(2	4tetrahydro-1-[(2	NOUN
eurjchem-2350	134	16	-	-	PUNCT
eurjchem-2350	134	17	phenylcyclopropyl	phenylcyclopropyl	ADJ
eurjchem-2350	134	18	)	)	PUNCT
eurjchem-2350	134	19	sulfonyl]-trans-(8ci	sulfonyl]-trans-(8ci	PROPN
eurjchem-2350	134	20	)	)	PUNCT
eurjchem-2350	134	21	can	can	AUX
eurjchem-2350	134	22	target	target	VERB
eurjchem-2350	134	23	main	main	ADJ
eurjchem-2350	134	24	proteases	protease	NOUN
eurjchem-2350	134	25	through	through	ADP
eurjchem-2350	134	26	interaction	interaction	NOUN
eurjchem-2350	134	27	with	with	ADP
eurjchem-2350	134	28	his41	his41	PROPN
eurjchem-2350	134	29	of	of	ADP
eurjchem-2350	134	30	sarscov-2	sarscov-2	NUM
eurjchem-2350	134	31	mpro	mpro	ADJ
eurjchem-2350	134	32	6lu7	6lu7	NUM
eurjchem-2350	135	1	[	[	X
eurjchem-2350	135	2	53	53	NUM
eurjchem-2350	135	3	]	]	PUNCT
eurjchem-2350	135	4	.	.	PUNCT
eurjchem-2350	136	1	similarly	similarly	ADV
eurjchem-2350	136	2	,	,	PUNCT
eurjchem-2350	136	3	our	our	PRON
eurjchem-2350	136	4	docking	docking	NOUN
eurjchem-2350	136	5	study	study	NOUN
eurjchem-2350	136	6	of	of	ADP
eurjchem-2350	136	7	molecule	molecule	NOUN
eurjchem-2350	136	8	q8	q8	PROPN
eurjchem-2350	136	9	against	against	ADP
eurjchem-2350	136	10	6yb7	6yb7	NUM
eurjchem-2350	136	11	was	be	AUX
eurjchem-2350	136	12	found	find	VERB
eurjchem-2350	136	13	to	to	PART
eurjchem-2350	136	14	have	have	VERB
eurjchem-2350	136	15	binding	bind	VERB
eurjchem-2350	136	16	interaction	interaction	NOUN
eurjchem-2350	136	17	with	with	ADP
eurjchem-2350	136	18	his41	his41	PROPN
eurjchem-2350	136	19	and	and	CCONJ
eurjchem-2350	136	20	forms	form	VERB
eurjchem-2350	136	21	the	the	DET
eurjchem-2350	136	22	2.1å	2.1å	NUM
eurjchem-2350	136	23	hydrogen	hydrogen	NOUN
eurjchem-2350	136	24	bond	bond	NOUN
eurjchem-2350	136	25	.	.	PUNCT
eurjchem-2350	137	1	on	on	ADP
eurjchem-2350	137	2	the	the	DET
eurjchem-2350	137	3	other	other	ADJ
eurjchem-2350	137	4	hand	hand	NOUN
eurjchem-2350	137	5	,	,	PUNCT
eurjchem-2350	137	6	standard	standard	ADJ
eurjchem-2350	137	7	drug	drug	NOUN
eurjchem-2350	137	8	molecules	molecule	NOUN
eurjchem-2350	137	9	,	,	PUNCT
eurjchem-2350	137	10	hcq	hcq	NOUN
eurjchem-2350	137	11	and	and	CCONJ
eurjchem-2350	137	12	rdv	rdv	NOUN
eurjchem-2350	137	13	,	,	PUNCT
eurjchem-2350	137	14	bind	bind	VERB
eurjchem-2350	137	15	to	to	ADP
eurjchem-2350	137	16	the	the	DET
eurjchem-2350	137	17	active	active	ADJ
eurjchem-2350	137	18	site	site	NOUN
eurjchem-2350	137	19	amino	amino	NOUN
eurjchem-2350	137	20	acids	acid	NOUN
eurjchem-2350	137	21	of	of	ADP
eurjchem-2350	137	22	the	the	DET
eurjchem-2350	137	23	five	five	NUM
eurjchem-2350	137	24	mpro	mpro	ADJ
eurjchem-2350	137	25	implicated	implicate	VERB
eurjchem-2350	137	26	in	in	ADP
eurjchem-2350	137	27	covid-19	covid-19	PROPN
eurjchem-2350	137	28	.	.	PUNCT
eurjchem-2350	138	1	however	however	ADV
eurjchem-2350	138	2	,	,	PUNCT
eurjchem-2350	138	3	the	the	DET
eurjchem-2350	138	4	binding	binding	NOUN
eurjchem-2350	138	5	to	to	ADP
eurjchem-2350	138	6	residues	residue	NOUN
eurjchem-2350	138	7	his41	his41	ADJ
eurjchem-2350	138	8	and	and	CCONJ
eurjchem-2350	138	9	glu166	glu166	PROPN
eurjchem-2350	138	10	of	of	ADP
eurjchem-2350	138	11	mpro	mpro	ADJ
eurjchem-2350	138	12	could	could	AUX
eurjchem-2350	138	13	be	be	AUX
eurjchem-2350	138	14	an	an	DET
eurjchem-2350	138	15	important	important	ADJ
eurjchem-2350	138	16	factor	factor	NOUN
eurjchem-2350	138	17	in	in	ADP
eurjchem-2350	138	18	the	the	DET
eurjchem-2350	138	19	inhibition	inhibition	NOUN
eurjchem-2350	138	20	of	of	ADP
eurjchem-2350	138	21	its	its	PRON
eurjchem-2350	138	22	protease	protease	NOUN
eurjchem-2350	138	23	activity	activity	NOUN
eurjchem-2350	138	24	.	.	PUNCT
eurjchem-2350	139	1	34	34	NUM
eurjchem-2350	139	2	kumar	kumar	PROPN
eurjchem-2350	139	3	et	et	PROPN
eurjchem-2350	139	4	al	al	PROPN
eurjchem-2350	139	5	.	.	PUNCT
eurjchem-2350	139	6	/	/	SYM
eurjchem-2350	139	7	european	european	PROPN
eurjchem-2350	139	8	journal	journal	PROPN
eurjchem-2350	139	9	of	of	ADP
eurjchem-2350	139	10	chemistry	chemistry	NOUN
eurjchem-2350	139	11	14	14	NUM
eurjchem-2350	139	12	(	(	PUNCT
eurjchem-2350	139	13	1	1	NUM
eurjchem-2350	139	14	)	)	PUNCT
eurjchem-2350	139	15	(	(	PUNCT
eurjchem-2350	139	16	2023	2023	NUM
eurjchem-2350	139	17	)	)	PUNCT
eurjchem-2350	139	18	30	30	NUM
eurjchem-2350	139	19	-	-	SYM
eurjchem-2350	139	20	38	38	NUM
eurjchem-2350	139	21	2023	2023	NUM
eurjchem-2350	139	22	–	–	PUNCT
eurjchem-2350	139	23	european	european	ADJ
eurjchem-2350	139	24	journal	journal	NOUN
eurjchem-2350	139	25	of	of	ADP
eurjchem-2350	139	26	chemistry	chemistry	NOUN
eurjchem-2350	139	27	–	–	PUNCT
eurjchem-2350	139	28	cc	cc	NOUN
eurjchem-2350	139	29	by	by	ADP
eurjchem-2350	139	30	nc	nc	PROPN
eurjchem-2350	139	31	–	–	PUNCT
eurjchem-2350	139	32	doi	doi	PROPN
eurjchem-2350	139	33	:	:	PUNCT
eurjchem-2350	139	34	10.5155	10.5155	NUM
eurjchem-2350	139	35	/	/	SYM
eurjchem-2350	139	36	eurjchem.14.1.30	eurjchem.14.1.30	PROPN
eurjchem-2350	139	37	-	-	PUNCT
eurjchem-2350	139	38	38.2350	38.2350	NUM
eurjchem-2350	139	39	1	1	NUM
eurjchem-2350	139	40	2	2	NUM
eurjchem-2350	139	41	3	3	NUM
eurjchem-2350	139	42	4	4	NUM
eurjchem-2350	139	43	5	5	NUM
eurjchem-2350	139	44	figure	figure	NOUN
eurjchem-2350	139	45	3	3	NUM
eurjchem-2350	139	46	.	.	PUNCT
eurjchem-2350	139	47	binding	bind	VERB
eurjchem-2350	139	48	interaction	interaction	NOUN
eurjchem-2350	139	49	of	of	ADP
eurjchem-2350	139	50	the	the	DET
eurjchem-2350	139	51	hit	hit	VERB
eurjchem-2350	139	52	quinoline	quinoline	NOUN
eurjchem-2350	139	53	derivatives	derivative	NOUN
eurjchem-2350	139	54	with	with	ADP
eurjchem-2350	139	55	covid-19	covid-19	PROPN
eurjchem-2350	139	56	mpro	mpro	ADJ
eurjchem-2350	139	57	(	(	PUNCT
eurjchem-2350	139	58	pdb	pdb	PROPN
eurjchem-2350	139	59	i	i	PROPN
eurjchem-2350	139	60	d	d	PROPN
eurjchem-2350	139	61	:	:	PUNCT
eurjchem-2350	139	62	6lu7	6lu7	NUM
eurjchem-2350	139	63	,	,	PUNCT
eurjchem-2350	139	64	6m03	6m03	NOUN
eurjchem-2350	139	65	,	,	PUNCT
eurjchem-2350	139	66	6w63	6w63	NUM
eurjchem-2350	139	67	,	,	PUNCT
eurjchem-2350	139	68	6y84	6y84	NOUN
eurjchem-2350	139	69	and	and	CCONJ
eurjchem-2350	139	70	6yb7	6yb7	NUM
eurjchem-2350	139	71	)	)	PUNCT
eurjchem-2350	139	72	is	be	AUX
eurjchem-2350	139	73	shown	show	VERB
eurjchem-2350	139	74	in	in	ADP
eurjchem-2350	139	75	rows	row	NOUN
eurjchem-2350	139	76	1	1	NUM
eurjchem-2350	139	77	,	,	PUNCT
eurjchem-2350	139	78	2	2	NUM
eurjchem-2350	139	79	,	,	PUNCT
eurjchem-2350	139	80	3	3	NUM
eurjchem-2350	139	81	,	,	PUNCT
eurjchem-2350	139	82	4	4	NUM
eurjchem-2350	139	83	and	and	CCONJ
eurjchem-2350	139	84	5	5	NUM
eurjchem-2350	139	85	,	,	PUNCT
eurjchem-2350	139	86	respectively	respectively	ADV
eurjchem-2350	139	87	.	.	PUNCT
eurjchem-2350	140	1	the	the	DET
eurjchem-2350	140	2	green	green	ADJ
eurjchem-2350	140	3	dotted	dotted	ADJ
eurjchem-2350	140	4	line	line	NOUN
eurjchem-2350	140	5	indicates	indicate	VERB
eurjchem-2350	140	6	the	the	DET
eurjchem-2350	140	7	hydrogen	hydrogen	NOUN
eurjchem-2350	140	8	bond	bond	NOUN
eurjchem-2350	140	9	.	.	PUNCT
eurjchem-2350	141	1	the	the	DET
eurjchem-2350	141	2	panels	panel	NOUN
eurjchem-2350	141	3	a	a	PRON
eurjchem-2350	141	4	,	,	PUNCT
eurjchem-2350	141	5	e	e	NOUN
eurjchem-2350	141	6	,	,	PUNCT
eurjchem-2350	141	7	i	i	PRON
eurjchem-2350	141	8	,	,	PUNCT
eurjchem-2350	141	9	m	m	VERB
eurjchem-2350	141	10	and	and	CCONJ
eurjchem-2350	141	11	q	q	AUX
eurjchem-2350	141	12	represent	represent	VERB
eurjchem-2350	141	13	interaction	interaction	NOUN
eurjchem-2350	141	14	with	with	ADP
eurjchem-2350	141	15	rdv	rdv	NOUN
eurjchem-2350	141	16	,	,	PUNCT
eurjchem-2350	141	17	panels	panel	NOUN
eurjchem-2350	141	18	b	b	PROPN
eurjchem-2350	141	19	,	,	PUNCT
eurjchem-2350	141	20	f	f	PROPN
eurjchem-2350	141	21	,	,	PUNCT
eurjchem-2350	141	22	i	i	PRON
eurjchem-2350	141	23	,	,	PUNCT
eurjchem-2350	141	24	n	n	PROPN
eurjchem-2350	141	25	and	and	CCONJ
eurjchem-2350	141	26	r	r	NOUN
eurjchem-2350	141	27	represent	represent	VERB
eurjchem-2350	141	28	interaction	interaction	NOUN
eurjchem-2350	141	29	with	with	ADP
eurjchem-2350	141	30	hcq	hcq	NOUN
eurjchem-2350	141	31	,	,	PUNCT
eurjchem-2350	141	32	panels	panel	NOUN
eurjchem-2350	141	33	c	c	NOUN
eurjchem-2350	141	34	,	,	PUNCT
eurjchem-2350	141	35	g	g	PROPN
eurjchem-2350	141	36	,	,	PUNCT
eurjchem-2350	141	37	k	k	PROPN
eurjchem-2350	141	38	,	,	PUNCT
eurjchem-2350	141	39	o	o	NOUN
eurjchem-2350	141	40	and	and	CCONJ
eurjchem-2350	141	41	s	s	AUX
eurjchem-2350	141	42	represent	represent	VERB
eurjchem-2350	141	43	interaction	interaction	NOUN
eurjchem-2350	141	44	with	with	ADP
eurjchem-2350	141	45	q9	q9	PROPN
eurjchem-2350	141	46	,	,	PUNCT
eurjchem-2350	141	47	q4	q4	PROPN
eurjchem-2350	141	48	,	,	PUNCT
eurjchem-2350	141	49	q9	q9	PROPN
eurjchem-2350	141	50	,	,	PUNCT
eurjchem-2350	141	51	q8	q8	PROPN
eurjchem-2350	141	52	and	and	CCONJ
eurjchem-2350	141	53	q9	q9	PROPN
eurjchem-2350	141	54	,	,	PUNCT
eurjchem-2350	141	55	and	and	CCONJ
eurjchem-2350	141	56	panels	panel	NOUN
eurjchem-2350	141	57	d	d	PROPN
eurjchem-2350	141	58	,	,	PUNCT
eurjchem-2350	141	59	h	h	NOUN
eurjchem-2350	141	60	,	,	PUNCT
eurjchem-2350	141	61	l	l	NOUN
eurjchem-2350	141	62	,	,	PUNCT
eurjchem-2350	141	63	p	p	NOUN
eurjchem-2350	141	64	and	and	CCONJ
eurjchem-2350	141	65	t	t	PROPN
eurjchem-2350	141	66	indicate	indicate	VERB
eurjchem-2350	141	67	the	the	DET
eurjchem-2350	141	68	interaction	interaction	NOUN
eurjchem-2350	141	69	with	with	ADP
eurjchem-2350	141	70	q10	q10	PROPN
eurjchem-2350	141	71	,	,	PUNCT
eurjchem-2350	141	72	q9	q9	PROPN
eurjchem-2350	141	73	,	,	PUNCT
eurjchem-2350	141	74	q10	q10	PROPN
eurjchem-2350	141	75	,	,	PUNCT
eurjchem-2350	141	76	q9	q9	PROPN
eurjchem-2350	141	77	and	and	CCONJ
eurjchem-2350	141	78	q10	q10	PROPN
eurjchem-2350	141	79	,	,	PUNCT
eurjchem-2350	141	80	respectively	respectively	ADV
eurjchem-2350	141	81	.	.	PUNCT
eurjchem-2350	142	1	we	we	PRON
eurjchem-2350	142	2	also	also	ADV
eurjchem-2350	142	3	analyzed	analyze	VERB
eurjchem-2350	142	4	the	the	DET
eurjchem-2350	142	5	protein	protein	NOUN
eurjchem-2350	142	6	-	-	PUNCT
eurjchem-2350	142	7	ligand	ligand	NOUN
eurjchem-2350	142	8	complexes	complex	NOUN
eurjchem-2350	142	9	to	to	PART
eurjchem-2350	142	10	better	well	ADV
eurjchem-2350	142	11	understand	understand	VERB
eurjchem-2350	142	12	the	the	DET
eurjchem-2350	142	13	interactions	interaction	NOUN
eurjchem-2350	142	14	between	between	ADP
eurjchem-2350	142	15	protein	protein	NOUN
eurjchem-2350	142	16	residues	residue	NOUN
eurjchem-2350	142	17	and	and	CCONJ
eurjchem-2350	142	18	the	the	DET
eurjchem-2350	142	19	bound	bind	VERB
eurjchem-2350	142	20	ligands	ligand	NOUN
eurjchem-2350	142	21	,	,	PUNCT
eurjchem-2350	142	22	along	along	ADP
eurjchem-2350	142	23	with	with	ADP
eurjchem-2350	142	24	the	the	DET
eurjchem-2350	142	25	binding	bind	VERB
eurjchem-2350	142	26	site	site	NOUN
eurjchem-2350	142	27	residues	residue	NOUN
eurjchem-2350	142	28	of	of	ADP
eurjchem-2350	142	29	the	the	DET
eurjchem-2350	142	30	defined	define	VERB
eurjchem-2350	142	31	receptor	receptor	NOUN
eurjchem-2350	142	32	.	.	PUNCT
eurjchem-2350	143	1	binding	bind	VERB
eurjchem-2350	143	2	of	of	ADP
eurjchem-2350	143	3	the	the	DET
eurjchem-2350	143	4	quinoline	quinoline	NOUN
eurjchem-2350	143	5	analogues	analogue	NOUN
eurjchem-2350	143	6	,	,	PUNCT
eurjchem-2350	143	7	hcq	hcq	NOUN
eurjchem-2350	143	8	and	and	CCONJ
eurjchem-2350	143	9	rdv	rdv	NOUN
eurjchem-2350	143	10	,	,	PUNCT
eurjchem-2350	143	11	with	with	ADP
eurjchem-2350	143	12	mpro	mpro	ADJ
eurjchem-2350	143	13	of	of	ADP
eurjchem-2350	143	14	the	the	DET
eurjchem-2350	143	15	covid-19	covid-19	PROPN
eurjchem-2350	143	16	receptors	receptor	NOUN
eurjchem-2350	143	17	indicated	indicate	VERB
eurjchem-2350	143	18	the	the	DET
eurjchem-2350	143	19	spontaneity	spontaneity	NOUN
eurjchem-2350	143	20	of	of	ADP
eurjchem-2350	143	21	binding	bind	VERB
eurjchem-2350	143	22	as	as	SCONJ
eurjchem-2350	143	23	confirmed	confirm	VERB
eurjchem-2350	143	24	by	by	ADP
eurjchem-2350	143	25	the	the	DET
eurjchem-2350	143	26	negative	negative	ADJ
eurjchem-2350	143	27	values	value	NOUN
eurjchem-2350	143	28	of	of	ADP
eurjchem-2350	143	29	free	free	ADJ
eurjchem-2350	143	30	energies	energy	NOUN
eurjchem-2350	143	31	and	and	CCONJ
eurjchem-2350	143	32	h	h	NOUN
eurjchem-2350	143	33	-	-	PUNCT
eurjchem-2350	143	34	bond	bond	NOUN
eurjchem-2350	143	35	formation	formation	NOUN
eurjchem-2350	143	36	.	.	PUNCT
eurjchem-2350	144	1	among	among	ADP
eurjchem-2350	144	2	several	several	ADJ
eurjchem-2350	144	3	ligand	ligand	ADJ
eurjchem-2350	144	4	molecules	molecule	NOUN
eurjchem-2350	144	5	,	,	PUNCT
eurjchem-2350	144	6	the	the	DET
eurjchem-2350	144	7	highly	highly	ADV
eurjchem-2350	144	8	potent	potent	ADJ
eurjchem-2350	144	9	ligands	ligand	NOUN
eurjchem-2350	144	10	with	with	ADP
eurjchem-2350	144	11	the	the	DET
eurjchem-2350	144	12	highest	high	ADJ
eurjchem-2350	144	13	binding	bind	VERB
eurjchem-2350	144	14	energy	energy	NOUN
eurjchem-2350	144	15	with	with	ADP
eurjchem-2350	144	16	each	each	PRON
eurjchem-2350	144	17	of	of	ADP
eurjchem-2350	144	18	the	the	DET
eurjchem-2350	144	19	mpro	mpro	ADJ
eurjchem-2350	144	20	are	be	AUX
eurjchem-2350	144	21	shown	show	VERB
eurjchem-2350	144	22	in	in	ADP
eurjchem-2350	144	23	table	table	NOUN
eurjchem-2350	144	24	2	2	NUM
eurjchem-2350	144	25	.	.	PUNCT
eurjchem-2350	145	1	the	the	DET
eurjchem-2350	145	2	data	datum	NOUN
eurjchem-2350	145	3	obtained	obtain	VERB
eurjchem-2350	145	4	here	here	ADV
eurjchem-2350	145	5	indicate	indicate	VERB
eurjchem-2350	145	6	that	that	SCONJ
eurjchem-2350	145	7	the	the	DET
eurjchem-2350	145	8	compound	compound	NOUN
eurjchem-2350	145	9	q9	q9	PROPN
eurjchem-2350	145	10	interacts	interact	VERB
eurjchem-2350	145	11	more	more	ADV
eurjchem-2350	145	12	effectively	effectively	ADV
eurjchem-2350	145	13	with	with	ADP
eurjchem-2350	145	14	the	the	DET
eurjchem-2350	145	15	five	five	NUM
eurjchem-2350	145	16	mpro	mpro	ADJ
eurjchem-2350	145	17	of	of	ADP
eurjchem-2350	145	18	covid-19	covid-19	PROPN
eurjchem-2350	145	19	and	and	CCONJ
eurjchem-2350	145	20	forms	form	NOUN
eurjchem-2350	145	21	two	two	NUM
eurjchem-2350	145	22	or	or	CCONJ
eurjchem-2350	145	23	more	more	ADJ
eurjchem-2350	145	24	hydrogen	hydrogen	NOUN
eurjchem-2350	145	25	bonds	bond	NOUN
eurjchem-2350	145	26	with	with	ADP
eurjchem-2350	145	27	each	each	DET
eurjchem-2350	145	28	target	target	NOUN
eurjchem-2350	145	29	receptor	receptor	NOUN
eurjchem-2350	145	30	;	;	PUNCT
eurjchem-2350	145	31	the	the	DET
eurjchem-2350	145	32	binding	bind	VERB
eurjchem-2350	145	33	energy	energy	NOUN
eurjchem-2350	145	34	ranged	range	VERB
eurjchem-2350	145	35	from	from	ADP
eurjchem-2350	145	36	-8.78	-8.78	NUM
eurjchem-2350	145	37	to-5.94	to-5.94	PROPN
eurjchem-2350	145	38	kcal	kcal	PROPN
eurjchem-2350	145	39	/	/	SYM
eurjchem-2350	145	40	mol	mol	PROPN
eurjchem-2350	145	41	.	.	PUNCT
eurjchem-2350	146	1	the	the	DET
eurjchem-2350	146	2	binding	bind	VERB
eurjchem-2350	146	3	interactions	interaction	NOUN
eurjchem-2350	146	4	between	between	ADP
eurjchem-2350	146	5	other	other	ADJ
eurjchem-2350	146	6	quinoline	quinoline	NOUN
eurjchem-2350	146	7	derivatives	derivative	NOUN
eurjchem-2350	146	8	with	with	ADP
eurjchem-2350	146	9	the	the	DET
eurjchem-2350	146	10	target	target	NOUN
eurjchem-2350	146	11	receptors	receptor	NOUN
eurjchem-2350	146	12	6lu7	6lu7	NUM
eurjchem-2350	146	13	,	,	PUNCT
eurjchem-2350	146	14	6y84	6y84	NOUN
eurjchem-2350	146	15	,	,	PUNCT
eurjchem-2350	146	16	and	and	CCONJ
eurjchem-2350	146	17	6m03	6m03	NOUN
eurjchem-2350	146	18	were	be	AUX
eurjchem-2350	146	19	also	also	ADV
eurjchem-2350	146	20	found	find	VERB
eurjchem-2350	146	21	to	to	PART
eurjchem-2350	146	22	be	be	AUX
eurjchem-2350	146	23	in	in	ADP
eurjchem-2350	146	24	the	the	DET
eurjchem-2350	146	25	negative	negative	ADJ
eurjchem-2350	146	26	range	range	NOUN
eurjchem-2350	146	27	,	,	PUNCT
eurjchem-2350	146	28	indicating	indicate	VERB
eurjchem-2350	146	29	a	a	DET
eurjchem-2350	146	30	significant	significant	ADJ
eurjchem-2350	146	31	interaction	interaction	NOUN
eurjchem-2350	146	32	involving	involve	VERB
eurjchem-2350	146	33	the	the	DET
eurjchem-2350	146	34	binding	binding	NOUN
eurjchem-2350	146	35	with	with	ADP
eurjchem-2350	146	36	the	the	DET
eurjchem-2350	146	37	most	most	ADV
eurjchem-2350	146	38	important	important	ADJ
eurjchem-2350	146	39	amino	amino	NOUN
eurjchem-2350	146	40	acid	acid	NOUN
eurjchem-2350	146	41	residue	residue	NOUN
eurjchem-2350	146	42	glu166	glu166	NOUN
eurjchem-2350	146	43	of	of	ADP
eurjchem-2350	146	44	mpro	mpro	ADJ
eurjchem-2350	146	45	.	.	PUNCT
eurjchem-2350	147	1	furthermore	furthermore	ADV
eurjchem-2350	147	2	,	,	PUNCT
eurjchem-2350	147	3	the	the	DET
eurjchem-2350	147	4	standard	standard	ADJ
eurjchem-2350	147	5	drug	drug	NOUN
eurjchem-2350	147	6	molecule	molecule	NOUN
eurjchem-2350	147	7	hcq	hcq	NOUN
eurjchem-2350	147	8	was	be	AUX
eurjchem-2350	147	9	also	also	ADV
eurjchem-2350	147	10	found	find	VERB
eurjchem-2350	147	11	to	to	PART
eurjchem-2350	147	12	interact	interact	VERB
eurjchem-2350	147	13	with	with	ADP
eurjchem-2350	147	14	glu166	glu166	NOUN
eurjchem-2350	147	15	of	of	ADP
eurjchem-2350	147	16	6m03	6m03	NOUN
eurjchem-2350	147	17	and	and	CCONJ
eurjchem-2350	147	18	6y84	6y84	NUM
eurjchem-2350	147	19	receptors	receptor	NOUN
eurjchem-2350	147	20	.	.	PUNCT
eurjchem-2350	148	1	the	the	DET
eurjchem-2350	148	2	binding	bind	VERB
eurjchem-2350	148	3	energy	energy	NOUN
eurjchem-2350	148	4	of	of	ADP
eurjchem-2350	148	5	hcq	hcq	NOUN
eurjchem-2350	148	6	to	to	ADP
eurjchem-2350	148	7	the	the	DET
eurjchem-2350	148	8	five	five	NUM
eurjchem-2350	148	9	receptors	receptor	NOUN
eurjchem-2350	148	10	ranged	range	VERB
eurjchem-2350	148	11	from	from	ADP
eurjchem-2350	148	12	-6.06	-6.06	NUM
eurjchem-2350	148	13	to	to	ADP
eurjchem-2350	148	14	-3.84kcal	-3.84kcal	ADJ
eurjchem-2350	148	15	/	/	SYM
eurjchem-2350	148	16	mol	mol	NOUN
eurjchem-2350	148	17	(	(	PUNCT
eurjchem-2350	148	18	table	table	NOUN
eurjchem-2350	148	19	2	2	NUM
eurjchem-2350	148	20	)	)	PUNCT
eurjchem-2350	148	21	.	.	PUNCT
eurjchem-2350	149	1	based	base	VERB
eurjchem-2350	149	2	on	on	ADP
eurjchem-2350	149	3	the	the	DET
eurjchem-2350	149	4	binding	bind	VERB
eurjchem-2350	149	5	energy	energy	NOUN
eurjchem-2350	149	6	and	and	CCONJ
eurjchem-2350	149	7	h	h	NOUN
eurjchem-2350	149	8	-	-	PUNCT
eurjchem-2350	149	9	bond	bond	NOUN
eurjchem-2350	149	10	formation	formation	NOUN
eurjchem-2350	149	11	,	,	PUNCT
eurjchem-2350	149	12	the	the	DET
eurjchem-2350	149	13	most	most	ADV
eurjchem-2350	149	14	potent	potent	ADJ
eurjchem-2350	149	15	compounds	compound	NOUN
eurjchem-2350	149	16	were	be	AUX
eurjchem-2350	149	17	found	find	VERB
eurjchem-2350	149	18	to	to	PART
eurjchem-2350	149	19	be	be	AUX
eurjchem-2350	149	20	q8	q8	PROPN
eurjchem-2350	149	21	(	(	PUNCT
eurjchem-2350	149	22	-9.87	-9.87	X
eurjchem-2350	149	23	to-3.91	to-3.91	PROPN
eurjchem-2350	149	24	kcal	kcal	X
eurjchem-2350	149	25	/	/	SYM
eurjchem-2350	149	26	mol	mol	NOUN
eurjchem-2350	149	27	)	)	PUNCT
eurjchem-2350	149	28	,	,	PUNCT
eurjchem-2350	149	29	q9	q9	PROPN
eurjchem-2350	149	30	(	(	PUNCT
eurjchem-2350	149	31	8.78	8.78	NUM
eurjchem-2350	149	32	to-5.94	to-5.94	PROPN
eurjchem-2350	149	33	kcal	kcal	NOUN
eurjchem-2350	149	34	/	/	SYM
eurjchem-2350	149	35	mol	mol	NOUN
eurjchem-2350	149	36	)	)	PUNCT
eurjchem-2350	149	37	and	and	CCONJ
eurjchem-2350	149	38	q10	q10	PROPN
eurjchem-2350	149	39	(	(	PUNCT
eurjchem-2350	149	40	-8.76	-8.76	PROPN
eurjchem-2350	149	41	to	to	PART
eurjchem-2350	149	42	-5.73	-5.73	NUM
eurjchem-2350	149	43	kcal	kcal	PROPN
eurjchem-2350	149	44	/	/	SYM
eurjchem-2350	149	45	mol	mol	NOUN
eurjchem-2350	149	46	)	)	PUNCT
eurjchem-2350	149	47	.	.	PUNCT
eurjchem-2350	150	1	on	on	ADP
eurjchem-2350	150	2	the	the	DET
eurjchem-2350	150	3	other	other	ADJ
eurjchem-2350	150	4	hand	hand	NOUN
eurjchem-2350	150	5	,	,	PUNCT
eurjchem-2350	150	6	both	both	CCONJ
eurjchem-2350	150	7	rdv	rdv	NOUN
eurjchem-2350	150	8	and	and	CCONJ
eurjchem-2350	150	9	hcq	hcq	PROPN
eurjchem-2350	150	10	also	also	ADV
eurjchem-2350	150	11	exhibited	exhibit	VERB
eurjchem-2350	150	12	the	the	DET
eurjchem-2350	150	13	binding	bind	VERB
eurjchem-2350	150	14	interaction	interaction	NOUN
eurjchem-2350	150	15	with	with	ADP
eurjchem-2350	150	16	glu166	glu166	NOUN
eurjchem-2350	150	17	,	,	PUNCT
eurjchem-2350	150	18	but	but	CCONJ
eurjchem-2350	150	19	formed	form	VERB
eurjchem-2350	150	20	less	less	ADJ
eurjchem-2350	150	21	number	number	NOUN
eurjchem-2350	150	22	of	of	ADP
eurjchem-2350	150	23	h	h	NOUN
eurjchem-2350	150	24	-	-	PUNCT
eurjchem-2350	150	25	bonds	bond	NOUN
eurjchem-2350	150	26	and	and	CCONJ
eurjchem-2350	150	27	weak	weak	ADJ
eurjchem-2350	150	28	binding	bind	VERB
eurjchem-2350	150	29	energies	energy	NOUN
eurjchem-2350	150	30	as	as	SCONJ
eurjchem-2350	150	31	compared	compare	VERB
eurjchem-2350	150	32	to	to	ADP
eurjchem-2350	150	33	the	the	DET
eurjchem-2350	150	34	quinoline	quinoline	NOUN
eurjchem-2350	150	35	analogues	analogue	NOUN
eurjchem-2350	150	36	(	(	PUNCT
eurjchem-2350	150	37	figure	figure	NOUN
eurjchem-2350	150	38	3	3	NUM
eurjchem-2350	150	39	)	)	PUNCT
eurjchem-2350	150	40	.	.	PUNCT
eurjchem-2350	151	1	kumar	kumar	PROPN
eurjchem-2350	151	2	et	et	PROPN
eurjchem-2350	151	3	al	al	PROPN
eurjchem-2350	151	4	.	.	PUNCT
eurjchem-2350	151	5	/	/	SYM
eurjchem-2350	151	6	european	european	PROPN
eurjchem-2350	151	7	journal	journal	PROPN
eurjchem-2350	151	8	of	of	ADP
eurjchem-2350	151	9	chemistry	chemistry	NOUN
eurjchem-2350	151	10	14	14	NUM
eurjchem-2350	151	11	(	(	PUNCT
eurjchem-2350	151	12	1	1	NUM
eurjchem-2350	151	13	)	)	PUNCT
eurjchem-2350	151	14	(	(	PUNCT
eurjchem-2350	151	15	2023	2023	NUM
eurjchem-2350	151	16	)	)	PUNCT
eurjchem-2350	151	17	30	30	NUM
eurjchem-2350	151	18	-	-	SYM
eurjchem-2350	151	19	38	38	NUM
eurjchem-2350	151	20	35	35	NUM
eurjchem-2350	151	21	2023	2023	NUM
eurjchem-2350	151	22	–	–	PUNCT
eurjchem-2350	151	23	european	european	ADJ
eurjchem-2350	151	24	journal	journal	NOUN
eurjchem-2350	151	25	of	of	ADP
eurjchem-2350	151	26	chemistry	chemistry	NOUN
eurjchem-2350	151	27	–	–	PUNCT
eurjchem-2350	151	28	cc	cc	NOUN
eurjchem-2350	151	29	by	by	ADP
eurjchem-2350	151	30	nc	nc	PROPN
eurjchem-2350	151	31	–	–	PUNCT
eurjchem-2350	151	32	doi	doi	PROPN
eurjchem-2350	151	33	:	:	PUNCT
eurjchem-2350	151	34	10.5155	10.5155	NUM
eurjchem-2350	151	35	/	/	SYM
eurjchem-2350	151	36	eurjchem.14.1.30	eurjchem.14.1.30	PROPN
eurjchem-2350	151	37	-	-	PUNCT
eurjchem-2350	151	38	38.2350	38.2350	NUM
eurjchem-2350	151	39	figure	figure	NOUN
eurjchem-2350	151	40	4	4	NUM
eurjchem-2350	151	41	.	.	NOUN
eurjchem-2350	151	42	solvation	solvation	NOUN
eurjchem-2350	151	43	process	process	NOUN
eurjchem-2350	151	44	of	of	ADP
eurjchem-2350	151	45	the	the	DET
eurjchem-2350	151	46	6lu7	6lu7	NUM
eurjchem-2350	151	47	and	and	CCONJ
eurjchem-2350	151	48	q9	q9	PROPN
eurjchem-2350	151	49	complexes	complex	NOUN
eurjchem-2350	151	50	.	.	PUNCT
eurjchem-2350	152	1	(	(	PUNCT
eurjchem-2350	152	2	a	a	X
eurjchem-2350	152	3	)	)	PUNCT
eurjchem-2350	152	4	(	(	PUNCT
eurjchem-2350	152	5	b	b	X
eurjchem-2350	152	6	)	)	PUNCT
eurjchem-2350	152	7	figure	figure	NOUN
eurjchem-2350	152	8	5	5	NUM
eurjchem-2350	152	9	.	.	PUNCT
eurjchem-2350	153	1	(	(	PUNCT
eurjchem-2350	153	2	a	a	X
eurjchem-2350	153	3	)	)	PUNCT
eurjchem-2350	153	4	rmsd	rmsd	NOUN
eurjchem-2350	153	5	and	and	CCONJ
eurjchem-2350	153	6	(	(	PUNCT
eurjchem-2350	153	7	b	b	NOUN
eurjchem-2350	153	8	)	)	PUNCT
eurjchem-2350	153	9	rmsf	rmsf	NOUN
eurjchem-2350	153	10	of	of	ADP
eurjchem-2350	153	11	various	various	ADJ
eurjchem-2350	153	12	conformations	conformation	NOUN
eurjchem-2350	153	13	of	of	ADP
eurjchem-2350	153	14	6lu7	6lu7	NUM
eurjchem-2350	153	15	and	and	CCONJ
eurjchem-2350	153	16	its	its	PRON
eurjchem-2350	153	17	complex	complex	ADJ
eurjchem-2350	153	18	residues	residue	NOUN
eurjchem-2350	153	19	.	.	PUNCT
eurjchem-2350	154	1	(	(	PUNCT
eurjchem-2350	154	2	a	a	X
eurjchem-2350	154	3	)	)	PUNCT
eurjchem-2350	154	4	(	(	PUNCT
eurjchem-2350	154	5	b	b	X
eurjchem-2350	154	6	)	)	PUNCT
eurjchem-2350	154	7	figure	figure	NOUN
eurjchem-2350	154	8	6	6	NUM
eurjchem-2350	154	9	.	.	PUNCT
eurjchem-2350	155	1	(	(	PUNCT
eurjchem-2350	155	2	a	a	X
eurjchem-2350	155	3	)	)	PUNCT
eurjchem-2350	155	4	time	time	NOUN
eurjchem-2350	155	5	based	base	VERB
eurjchem-2350	155	6	total	total	ADJ
eurjchem-2350	155	7	energy	energy	NOUN
eurjchem-2350	155	8	and	and	CCONJ
eurjchem-2350	155	9	(	(	PUNCT
eurjchem-2350	155	10	b	b	NOUN
eurjchem-2350	155	11	)	)	PUNCT
eurjchem-2350	155	12	temperature	temperature	NOUN
eurjchem-2350	155	13	changes	change	NOUN
eurjchem-2350	155	14	on	on	ADP
eurjchem-2350	155	15	different	different	ADJ
eurjchem-2350	155	16	time	time	NOUN
eurjchem-2350	155	17	scales	scale	NOUN
eurjchem-2350	155	18	of	of	ADP
eurjchem-2350	155	19	6lu7	6lu7	NUM
eurjchem-2350	155	20	and	and	CCONJ
eurjchem-2350	155	21	its	its	PRON
eurjchem-2350	155	22	complex	complex	NOUN
eurjchem-2350	155	23	.	.	PUNCT
eurjchem-2350	156	1	3.3	3.3	NUM
eurjchem-2350	156	2	.	.	PUNCT
eurjchem-2350	157	1	molecular	molecular	ADJ
eurjchem-2350	157	2	dynamic	dynamic	ADJ
eurjchem-2350	157	3	simulation	simulation	NOUN
eurjchem-2350	157	4	studies	study	VERB
eurjchem-2350	157	5	the	the	DET
eurjchem-2350	157	6	molecular	molecular	ADJ
eurjchem-2350	157	7	dynamics	dynamic	NOUN
eurjchem-2350	157	8	(	(	PUNCT
eurjchem-2350	157	9	md	md	PROPN
eurjchem-2350	157	10	)	)	PUNCT
eurjchem-2350	157	11	simulation	simulation	NOUN
eurjchem-2350	157	12	was	be	AUX
eurjchem-2350	157	13	focused	focus	VERB
eurjchem-2350	157	14	on	on	ADP
eurjchem-2350	157	15	the	the	DET
eurjchem-2350	157	16	lead	lead	ADJ
eurjchem-2350	157	17	molecule	molecule	NOUN
eurjchem-2350	157	18	q9	q9	PROPN
eurjchem-2350	157	19	as	as	ADV
eurjchem-2350	157	20	well	well	ADV
eurjchem-2350	157	21	as	as	ADP
eurjchem-2350	157	22	q9	q9	PROPN
eurjchem-2350	157	23	with	with	ADP
eurjchem-2350	157	24	mpro	mpro	ADJ
eurjchem-2350	157	25	of	of	ADP
eurjchem-2350	157	26	covid-19	covid-19	PROPN
eurjchem-2350	157	27	receptor	receptor	NOUN
eurjchem-2350	157	28	6lu7	6lu7	NUM
eurjchem-2350	157	29	.	.	PUNCT
eurjchem-2350	158	1	we	we	PRON
eurjchem-2350	158	2	evaluated	evaluate	VERB
eurjchem-2350	158	3	the	the	DET
eurjchem-2350	158	4	properties	property	NOUN
eurjchem-2350	158	5	of	of	ADP
eurjchem-2350	158	6	the	the	DET
eurjchem-2350	158	7	receptor	receptor	NOUN
eurjchem-2350	158	8	,	,	PUNCT
eurjchem-2350	158	9	the	the	DET
eurjchem-2350	158	10	stability	stability	NOUN
eurjchem-2350	158	11	of	of	ADP
eurjchem-2350	158	12	the	the	DET
eurjchem-2350	158	13	ligand	ligand	ADJ
eurjchem-2350	158	14	-	-	PUNCT
eurjchem-2350	158	15	receptor	receptor	NOUN
eurjchem-2350	158	16	complex	complex	NOUN
eurjchem-2350	158	17	(	(	PUNCT
eurjchem-2350	158	18	6lu7	6lu7	NUM
eurjchem-2350	158	19	with	with	ADP
eurjchem-2350	158	20	q9	q9	PROPN
eurjchem-2350	158	21	)	)	PUNCT
eurjchem-2350	158	22	,	,	PUNCT
eurjchem-2350	158	23	and	and	CCONJ
eurjchem-2350	158	24	the	the	DET
eurjchem-2350	158	25	conformation	conformation	NOUN
eurjchem-2350	158	26	changes	change	VERB
eurjchem-2350	158	27	in	in	ADP
eurjchem-2350	158	28	different	different	ADJ
eurjchem-2350	158	29	temperatures	temperature	NOUN
eurjchem-2350	158	30	(	(	PUNCT
eurjchem-2350	158	31	k	k	NOUN
eurjchem-2350	158	32	)	)	PUNCT
eurjchem-2350	158	33	and	and	CCONJ
eurjchem-2350	158	34	energy	energy	NOUN
eurjchem-2350	158	35	functions	function	NOUN
eurjchem-2350	158	36	(	(	PUNCT
eurjchem-2350	158	37	kcal	kcal	NOUN
eurjchem-2350	158	38	/	/	SYM
eurjchem-2350	158	39	mol	mol	PROPN
eurjchem-2350	158	40	)	)	PUNCT
eurjchem-2350	158	41	the	the	DET
eurjchem-2350	158	42	results	result	NOUN
eurjchem-2350	158	43	of	of	ADP
eurjchem-2350	158	44	molecular	molecular	ADJ
eurjchem-2350	158	45	docking	docking	NOUN
eurjchem-2350	158	46	study	study	NOUN
eurjchem-2350	158	47	suggested	suggest	VERB
eurjchem-2350	158	48	that	that	SCONJ
eurjchem-2350	158	49	ligand	ligand	PROPN
eurjchem-2350	158	50	q9	q9	PROPN
eurjchem-2350	158	51	possesses	possess	VERB
eurjchem-2350	158	52	good	good	ADJ
eurjchem-2350	158	53	binding	bind	VERB
eurjchem-2350	158	54	affinity	affinity	NOUN
eurjchem-2350	158	55	with	with	ADP
eurjchem-2350	158	56	the	the	DET
eurjchem-2350	158	57	6lu7	6lu7	NUM
eurjchem-2350	158	58	receptor	receptor	NOUN
eurjchem-2350	158	59	of	of	ADP
eurjchem-2350	158	60	covid-19	covid-19	PROPN
eurjchem-2350	158	61	.	.	PUNCT
eurjchem-2350	159	1	thus	thus	ADV
eurjchem-2350	159	2	,	,	PUNCT
eurjchem-2350	159	3	we	we	PRON
eurjchem-2350	159	4	selected	select	VERB
eurjchem-2350	159	5	this	this	DET
eurjchem-2350	159	6	complex	complex	ADJ
eurjchem-2350	159	7	protein	protein	NOUN
eurjchem-2350	159	8	for	for	ADP
eurjchem-2350	159	9	further	further	ADJ
eurjchem-2350	159	10	md	md	PROPN
eurjchem-2350	159	11	analysis	analysis	NOUN
eurjchem-2350	159	12	to	to	PART
eurjchem-2350	159	13	determine	determine	VERB
eurjchem-2350	159	14	the	the	DET
eurjchem-2350	159	15	stability	stability	NOUN
eurjchem-2350	159	16	changes	change	NOUN
eurjchem-2350	159	17	.	.	PUNCT
eurjchem-2350	160	1	in	in	ADP
eurjchem-2350	160	2	the	the	DET
eurjchem-2350	160	3	solvation	solvation	NOUN
eurjchem-2350	160	4	process	process	NOUN
eurjchem-2350	160	5	of	of	ADP
eurjchem-2350	160	6	the	the	DET
eurjchem-2350	160	7	explicit	explicit	ADJ
eurjchem-2350	160	8	periodic	periodic	ADJ
eurjchem-2350	160	9	border	border	NOUN
eurjchem-2350	160	10	cell	cell	NOUN
eurjchem-2350	160	11	,	,	PUNCT
eurjchem-2350	160	12	1247	1247	NUM
eurjchem-2350	160	13	water	water	NOUN
eurjchem-2350	160	14	molecules	molecule	NOUN
eurjchem-2350	160	15	,	,	PUNCT
eurjchem-2350	160	16	67	67	NUM
eurjchem-2350	160	17	sodium	sodium	NOUN
eurjchem-2350	160	18	ions	ion	NOUN
eurjchem-2350	160	19	and	and	CCONJ
eurjchem-2350	160	20	55	55	NUM
eurjchem-2350	160	21	chloride	chloride	NOUN
eurjchem-2350	160	22	ions	ion	NOUN
eurjchem-2350	160	23	were	be	AUX
eurjchem-2350	160	24	observed	observe	VERB
eurjchem-2350	160	25	.	.	PUNCT
eurjchem-2350	161	1	the	the	DET
eurjchem-2350	161	2	molecular	molecular	ADJ
eurjchem-2350	161	3	conformation	conformation	NOUN
eurjchem-2350	161	4	,	,	PUNCT
eurjchem-2350	161	5	electronic	electronic	ADJ
eurjchem-2350	161	6	properties	property	NOUN
eurjchem-2350	161	7	,	,	PUNCT
eurjchem-2350	161	8	and	and	CCONJ
eurjchem-2350	161	9	binding	bind	VERB
eurjchem-2350	161	10	energies	energy	NOUN
eurjchem-2350	161	11	of	of	ADP
eurjchem-2350	161	12	the	the	DET
eurjchem-2350	161	13	6lu7	6lu7	NUM
eurjchem-2350	161	14	complex	complex	NOUN
eurjchem-2350	161	15	were	be	AUX
eurjchem-2350	161	16	further	far	ADV
eurjchem-2350	161	17	determined	determine	VERB
eurjchem-2350	161	18	(	(	PUNCT
eurjchem-2350	161	19	figure	figure	NOUN
eurjchem-2350	161	20	4	4	NUM
eurjchem-2350	161	21	)	)	PUNCT
eurjchem-2350	161	22	.	.	PUNCT
eurjchem-2350	162	1	during	during	ADP
eurjchem-2350	162	2	the	the	DET
eurjchem-2350	162	3	md	md	PROPN
eurjchem-2350	162	4	simulations	simulation	NOUN
eurjchem-2350	162	5	,	,	PUNCT
eurjchem-2350	162	6	the	the	DET
eurjchem-2350	162	7	stability	stability	NOUN
eurjchem-2350	162	8	of	of	ADP
eurjchem-2350	162	9	each	each	DET
eurjchem-2350	162	10	conformation	conformation	NOUN
eurjchem-2350	162	11	of	of	ADP
eurjchem-2350	162	12	6lu7	6lu7	NUM
eurjchem-2350	162	13	and	and	CCONJ
eurjchem-2350	162	14	6lu7	6lu7	NUM
eurjchem-2350	162	15	with	with	ADP
eurjchem-2350	162	16	q9	q9	PROPN
eurjchem-2350	162	17	were	be	AUX
eurjchem-2350	162	18	monitored	monitor	VERB
eurjchem-2350	162	19	through	through	ADP
eurjchem-2350	162	20	the	the	DET
eurjchem-2350	162	21	root	root	NOUN
eurjchem-2350	162	22	mean	mean	ADJ
eurjchem-2350	162	23	square	square	ADJ
eurjchem-2350	162	24	deviation	deviation	NOUN
eurjchem-2350	162	25	(	(	PUNCT
eurjchem-2350	162	26	rmsd	rmsd	NOUN
eurjchem-2350	162	27	)	)	PUNCT
eurjchem-2350	162	28	and	and	CCONJ
eurjchem-2350	162	29	root	root	NOUN
eurjchem-2350	162	30	mean	mean	ADJ
eurjchem-2350	162	31	square	square	ADJ
eurjchem-2350	162	32	fluctuation	fluctuation	NOUN
eurjchem-2350	162	33	(	(	PUNCT
eurjchem-2350	162	34	rmsf	rmsf	NOUN
eurjchem-2350	162	35	)	)	PUNCT
eurjchem-2350	162	36	.	.	PUNCT
eurjchem-2350	163	1	the	the	DET
eurjchem-2350	163	2	analysis	analysis	NOUN
eurjchem-2350	163	3	indicates	indicate	VERB
eurjchem-2350	163	4	the	the	DET
eurjchem-2350	163	5	rmsd	rmsd	ADJ
eurjchem-2350	163	6	values	value	NOUN
eurjchem-2350	163	7	of	of	ADP
eurjchem-2350	163	8	1.0	1.0	NUM
eurjchem-2350	163	9	and	and	CCONJ
eurjchem-2350	163	10	0.9	0.9	NUM
eurjchem-2350	163	11	å	å	PROPN
eurjchem-2350	163	12	for	for	ADP
eurjchem-2350	163	13	6lu7	6lu7	NUM
eurjchem-2350	163	14	and	and	CCONJ
eurjchem-2350	163	15	6lu7	6lu7	NUM
eurjchem-2350	163	16	with	with	ADP
eurjchem-2350	163	17	q9	q9	PROPN
eurjchem-2350	163	18	,	,	PUNCT
eurjchem-2350	163	19	respectively	respectively	ADV
eurjchem-2350	163	20	(	(	PUNCT
eurjchem-2350	163	21	figure	figure	NOUN
eurjchem-2350	163	22	5	5	NUM
eurjchem-2350	163	23	)	)	PUNCT
eurjchem-2350	163	24	.	.	PUNCT
eurjchem-2350	164	1	from	from	ADP
eurjchem-2350	164	2	the	the	DET
eurjchem-2350	164	3	results	result	NOUN
eurjchem-2350	164	4	of	of	ADP
eurjchem-2350	164	5	the	the	DET
eurjchem-2350	164	6	rmsd	rmsd	NOUN
eurjchem-2350	164	7	and	and	CCONJ
eurjchem-2350	164	8	rmsf	rmsf	NOUN
eurjchem-2350	164	9	analysis	analysis	NOUN
eurjchem-2350	164	10	,	,	PUNCT
eurjchem-2350	164	11	it	it	PRON
eurjchem-2350	164	12	is	be	AUX
eurjchem-2350	164	13	clear	clear	ADJ
eurjchem-2350	164	14	that	that	SCONJ
eurjchem-2350	164	15	the	the	DET
eurjchem-2350	164	16	q9	q9	PROPN
eurjchem-2350	164	17	ligand	ligand	NOUN
eurjchem-2350	164	18	does	do	AUX
eurjchem-2350	164	19	not	not	PART
eurjchem-2350	164	20	change	change	VERB
eurjchem-2350	164	21	the	the	DET
eurjchem-2350	164	22	36	36	NUM
eurjchem-2350	164	23	kumar	kumar	PROPN
eurjchem-2350	164	24	et	et	PROPN
eurjchem-2350	164	25	al	al	PROPN
eurjchem-2350	164	26	.	.	PUNCT
eurjchem-2350	164	27	/	/	SYM
eurjchem-2350	164	28	european	european	PROPN
eurjchem-2350	164	29	journal	journal	PROPN
eurjchem-2350	164	30	of	of	ADP
eurjchem-2350	164	31	chemistry	chemistry	NOUN
eurjchem-2350	164	32	14	14	NUM
eurjchem-2350	164	33	(	(	PUNCT
eurjchem-2350	164	34	1	1	NUM
eurjchem-2350	164	35	)	)	PUNCT
eurjchem-2350	164	36	(	(	PUNCT
eurjchem-2350	164	37	2023	2023	NUM
eurjchem-2350	164	38	)	)	PUNCT
eurjchem-2350	164	39	30	30	NUM
eurjchem-2350	164	40	-	-	SYM
eurjchem-2350	164	41	38	38	NUM
eurjchem-2350	164	42	2023	2023	NUM
eurjchem-2350	164	43	–	–	PUNCT
eurjchem-2350	164	44	european	european	ADJ
eurjchem-2350	164	45	journal	journal	NOUN
eurjchem-2350	164	46	of	of	ADP
eurjchem-2350	164	47	chemistry	chemistry	NOUN
eurjchem-2350	164	48	–	–	PUNCT
eurjchem-2350	164	49	cc	cc	NOUN
eurjchem-2350	164	50	by	by	ADP
eurjchem-2350	164	51	nc	nc	PROPN
eurjchem-2350	164	52	–	–	PUNCT
eurjchem-2350	164	53	doi	doi	PROPN
eurjchem-2350	164	54	:	:	PUNCT
eurjchem-2350	164	55	10.5155	10.5155	NUM
eurjchem-2350	164	56	/	/	SYM
eurjchem-2350	164	57	eurjchem.14.1.30	eurjchem.14.1.30	PROPN
eurjchem-2350	164	58	-	-	PUNCT
eurjchem-2350	164	59	38.2350	38.2350	NUM
eurjchem-2350	164	60	conformation	conformation	NOUN
eurjchem-2350	164	61	of	of	ADP
eurjchem-2350	164	62	6lu7	6lu7	NUM
eurjchem-2350	164	63	,	,	PUNCT
eurjchem-2350	164	64	including	include	VERB
eurjchem-2350	164	65	the	the	DET
eurjchem-2350	164	66	structure	structure	NOUN
eurjchem-2350	164	67	of	of	ADP
eurjchem-2350	164	68	residues	residue	NOUN
eurjchem-2350	164	69	.	.	PUNCT
eurjchem-2350	165	1	we	we	PRON
eurjchem-2350	165	2	have	have	AUX
eurjchem-2350	165	3	also	also	ADV
eurjchem-2350	165	4	determined	determine	VERB
eurjchem-2350	165	5	the	the	DET
eurjchem-2350	165	6	total	total	ADJ
eurjchem-2350	165	7	energy	energy	NOUN
eurjchem-2350	165	8	variation	variation	NOUN
eurjchem-2350	165	9	and	and	CCONJ
eurjchem-2350	165	10	the	the	DET
eurjchem-2350	165	11	stabilization	stabilization	NOUN
eurjchem-2350	165	12	temperature	temperature	NOUN
eurjchem-2350	165	13	of	of	ADP
eurjchem-2350	165	14	the	the	DET
eurjchem-2350	165	15	protein	protein	NOUN
eurjchem-2350	165	16	complex	complex	NOUN
eurjchem-2350	165	17	(	(	PUNCT
eurjchem-2350	165	18	figure	figure	NOUN
eurjchem-2350	165	19	6	6	NUM
eurjchem-2350	165	20	)	)	PUNCT
eurjchem-2350	165	21	.	.	PUNCT
eurjchem-2350	166	1	the	the	DET
eurjchem-2350	166	2	receptor	receptor	NOUN
eurjchem-2350	166	3	was	be	AUX
eurjchem-2350	166	4	found	find	VERB
eurjchem-2350	166	5	to	to	PART
eurjchem-2350	166	6	stabilize	stabilize	VERB
eurjchem-2350	166	7	at	at	ADP
eurjchem-2350	166	8	210ps	210ps	ADJ
eurjchem-2350	166	9	time	time	NOUN
eurjchem-2350	166	10	between	between	ADP
eurjchem-2350	166	11	300304k	300304k	NUM
eurjchem-2350	166	12	temperatures	temperature	NOUN
eurjchem-2350	166	13	.	.	PUNCT
eurjchem-2350	167	1	finally	finally	ADV
eurjchem-2350	167	2	,	,	PUNCT
eurjchem-2350	167	3	the	the	DET
eurjchem-2350	167	4	ligand	ligand	ADJ
eurjchem-2350	167	5	q9	q9	PROPN
eurjchem-2350	167	6	does	do	AUX
eurjchem-2350	167	7	not	not	PART
eurjchem-2350	167	8	influence	influence	VERB
eurjchem-2350	167	9	the	the	DET
eurjchem-2350	167	10	rmsd	rmsd	NOUN
eurjchem-2350	167	11	and	and	CCONJ
eurjchem-2350	167	12	stability	stability	NOUN
eurjchem-2350	167	13	of	of	ADP
eurjchem-2350	167	14	the	the	DET
eurjchem-2350	167	15	6lu7	6lu7	NUM
eurjchem-2350	167	16	protein	protein	NOUN
eurjchem-2350	167	17	at	at	ADP
eurjchem-2350	167	18	various	various	ADJ
eurjchem-2350	167	19	temperatures	temperature	NOUN
eurjchem-2350	167	20	and	and	CCONJ
eurjchem-2350	167	21	energy	energy	NOUN
eurjchem-2350	167	22	values	value	NOUN
eurjchem-2350	167	23	based	base	VERB
eurjchem-2350	167	24	on	on	ADP
eurjchem-2350	167	25	these	these	DET
eurjchem-2350	167	26	md	md	PROPN
eurjchem-2350	167	27	findings	finding	NOUN
eurjchem-2350	167	28	.	.	PUNCT
eurjchem-2350	168	1	4	4	X
eurjchem-2350	168	2	.	.	X
eurjchem-2350	168	3	conclusions	conclusion	NOUN
eurjchem-2350	168	4	currently	currently	ADV
eurjchem-2350	168	5	,	,	PUNCT
eurjchem-2350	168	6	there	there	PRON
eurjchem-2350	168	7	are	be	VERB
eurjchem-2350	168	8	no	no	DET
eurjchem-2350	168	9	approved	approve	VERB
eurjchem-2350	168	10	drugs	drug	NOUN
eurjchem-2350	168	11	/	/	SYM
eurjchem-2350	168	12	vaccines	vaccine	NOUN
eurjchem-2350	168	13	for	for	ADP
eurjchem-2350	168	14	the	the	DET
eurjchem-2350	168	15	treatment	treatment	NOUN
eurjchem-2350	168	16	of	of	ADP
eurjchem-2350	168	17	covid-19	covid-19	PROPN
eurjchem-2350	168	18	infections	infection	NOUN
eurjchem-2350	168	19	.	.	PUNCT
eurjchem-2350	169	1	in	in	ADP
eurjchem-2350	169	2	addition	addition	NOUN
eurjchem-2350	169	3	to	to	ADP
eurjchem-2350	169	4	discovering	discover	VERB
eurjchem-2350	169	5	a	a	DET
eurjchem-2350	169	6	potent	potent	ADJ
eurjchem-2350	169	7	and	and	CCONJ
eurjchem-2350	169	8	specific	specific	ADJ
eurjchem-2350	169	9	drug	drug	NOUN
eurjchem-2350	169	10	,	,	PUNCT
eurjchem-2350	169	11	it	it	PRON
eurjchem-2350	169	12	is	be	AUX
eurjchem-2350	169	13	urgently	urgently	ADV
eurjchem-2350	169	14	needed	need	VERB
eurjchem-2350	169	15	to	to	PART
eurjchem-2350	169	16	develop	develop	VERB
eurjchem-2350	169	17	universal	universal	ADJ
eurjchem-2350	169	18	broad	broad	ADJ
eurjchem-2350	169	19	-	-	PUNCT
eurjchem-2350	169	20	spectrum	spectrum	NOUN
eurjchem-2350	169	21	vaccines	vaccine	NOUN
eurjchem-2350	169	22	against	against	ADP
eurjchem-2350	169	23	covid-19	covid-19	PROPN
eurjchem-2350	169	24	and	and	CCONJ
eurjchem-2350	169	25	other	other	ADJ
eurjchem-2350	169	26	sars	sar	NOUN
eurjchem-2350	169	27	or	or	CCONJ
eurjchem-2350	169	28	influenza	influenza	NOUN
eurjchem-2350	169	29	viruses	virus	NOUN
eurjchem-2350	169	30	to	to	PART
eurjchem-2350	169	31	combat	combat	VERB
eurjchem-2350	169	32	future	future	ADJ
eurjchem-2350	169	33	pandemics	pandemic	NOUN
eurjchem-2350	169	34	.	.	PUNCT
eurjchem-2350	170	1	in	in	ADP
eurjchem-2350	170	2	this	this	DET
eurjchem-2350	170	3	direction	direction	NOUN
eurjchem-2350	170	4	,	,	PUNCT
eurjchem-2350	170	5	we	we	PRON
eurjchem-2350	170	6	intended	intend	VERB
eurjchem-2350	170	7	to	to	PART
eurjchem-2350	170	8	expose	expose	VERB
eurjchem-2350	170	9	the	the	DET
eurjchem-2350	170	10	therapeutic	therapeutic	ADJ
eurjchem-2350	170	11	potential	potential	NOUN
eurjchem-2350	170	12	of	of	ADP
eurjchem-2350	170	13	certain	certain	ADJ
eurjchem-2350	170	14	quinoline	quinoline	NOUN
eurjchem-2350	170	15	derivatives	derivative	NOUN
eurjchem-2350	170	16	with	with	ADP
eurjchem-2350	170	17	respect	respect	NOUN
eurjchem-2350	170	18	to	to	ADP
eurjchem-2350	170	19	sars	sars	PROPN
eurjchem-2350	170	20	cov-2	cov-2	PART
eurjchem-2350	170	21	’s	’s	PART
eurjchem-2350	170	22	five	five	NUM
eurjchem-2350	170	23	main	main	ADJ
eurjchem-2350	170	24	proteases	protease	NOUN
eurjchem-2350	170	25	.	.	PUNCT
eurjchem-2350	171	1	the	the	DET
eurjchem-2350	171	2	molecule	molecule	NOUN
eurjchem-2350	171	3	bearing	bear	VERB
eurjchem-2350	171	4	quinoline	quinoline	NOUN
eurjchem-2350	171	5	scaffolds	scaffold	NOUN
eurjchem-2350	171	6	is	be	AUX
eurjchem-2350	171	7	widespread	widespread	ADJ
eurjchem-2350	171	8	in	in	ADP
eurjchem-2350	171	9	various	various	ADJ
eurjchem-2350	171	10	potent	potent	ADJ
eurjchem-2350	171	11	bioactive	bioactive	NOUN
eurjchem-2350	171	12	natural	natural	ADJ
eurjchem-2350	171	13	and	and	CCONJ
eurjchem-2350	171	14	synthetic	synthetic	ADJ
eurjchem-2350	171	15	compounds	compound	NOUN
eurjchem-2350	171	16	.	.	PUNCT
eurjchem-2350	172	1	quinoline	quinoline	NOUN
eurjchem-2350	172	2	-	-	PUNCT
eurjchem-2350	172	3	based	base	VERB
eurjchem-2350	172	4	antimalarial	antimalarial	ADJ
eurjchem-2350	172	5	drugs	drug	NOUN
eurjchem-2350	172	6	,	,	PUNCT
eurjchem-2350	172	7	such	such	ADJ
eurjchem-2350	172	8	as	as	ADP
eurjchem-2350	172	9	hcq	hcq	NOUN
eurjchem-2350	172	10	and	and	CCONJ
eurjchem-2350	172	11	cq	cq	PROPN
eurjchem-2350	172	12	,	,	PUNCT
eurjchem-2350	172	13	have	have	AUX
eurjchem-2350	172	14	shown	show	VERB
eurjchem-2350	172	15	significant	significant	ADJ
eurjchem-2350	172	16	efficacy	efficacy	NOUN
eurjchem-2350	172	17	in	in	ADP
eurjchem-2350	172	18	the	the	DET
eurjchem-2350	172	19	treatment	treatment	NOUN
eurjchem-2350	172	20	of	of	ADP
eurjchem-2350	172	21	covid-19	covid-19	PROPN
eurjchem-2350	172	22	infections	infection	NOUN
eurjchem-2350	172	23	[	[	X
eurjchem-2350	172	24	54,55	54,55	X
eurjchem-2350	172	25	]	]	PUNCT
eurjchem-2350	172	26	.	.	PUNCT
eurjchem-2350	173	1	several	several	ADJ
eurjchem-2350	173	2	quinoline	quinoline	NOUN
eurjchem-2350	173	3	-	-	PUNCT
eurjchem-2350	173	4	based	base	VERB
eurjchem-2350	173	5	drug	drug	NOUN
eurjchem-2350	173	6	candidates	candidate	NOUN
eurjchem-2350	173	7	have	have	AUX
eurjchem-2350	173	8	been	be	AUX
eurjchem-2350	173	9	identified	identify	VERB
eurjchem-2350	173	10	to	to	PART
eurjchem-2350	173	11	have	have	VERB
eurjchem-2350	173	12	a	a	DET
eurjchem-2350	173	13	connection	connection	NOUN
eurjchem-2350	173	14	with	with	ADP
eurjchem-2350	173	15	covid-19	covid-19	PROPN
eurjchem-2350	173	16	or	or	CCONJ
eurjchem-2350	173	17	a	a	DET
eurjchem-2350	173	18	role	role	NOUN
eurjchem-2350	173	19	in	in	ADP
eurjchem-2350	173	20	suppressing	suppress	VERB
eurjchem-2350	173	21	viral	viral	ADJ
eurjchem-2350	173	22	progression	progression	NOUN
eurjchem-2350	173	23	and	and	CCONJ
eurjchem-2350	173	24	possess	possess	VERB
eurjchem-2350	173	25	a	a	DET
eurjchem-2350	173	26	wide	wide	ADJ
eurjchem-2350	173	27	range	range	NOUN
eurjchem-2350	173	28	of	of	ADP
eurjchem-2350	173	29	antiviral	antiviral	ADJ
eurjchem-2350	173	30	activity	activity	NOUN
eurjchem-2350	173	31	[	[	X
eurjchem-2350	173	32	56	56	NUM
eurjchem-2350	173	33	]	]	PUNCT
eurjchem-2350	173	34	.	.	PUNCT
eurjchem-2350	174	1	the	the	DET
eurjchem-2350	174	2	strong	strong	ADJ
eurjchem-2350	174	3	safety	safety	NOUN
eurjchem-2350	174	4	profile	profile	NOUN
eurjchem-2350	174	5	of	of	ADP
eurjchem-2350	174	6	aminoquinolines	aminoquinoline	NOUN
eurjchem-2350	174	7	at	at	ADP
eurjchem-2350	174	8	the	the	DET
eurjchem-2350	174	9	currently	currently	ADV
eurjchem-2350	174	10	recommended	recommend	VERB
eurjchem-2350	174	11	doses	dose	NOUN
eurjchem-2350	174	12	for	for	ADP
eurjchem-2350	174	13	the	the	DET
eurjchem-2350	174	14	prevention	prevention	NOUN
eurjchem-2350	174	15	or	or	CCONJ
eurjchem-2350	174	16	early	early	ADJ
eurjchem-2350	174	17	treatment	treatment	NOUN
eurjchem-2350	174	18	of	of	ADP
eurjchem-2350	174	19	covid-19	covid-19	PROPN
eurjchem-2350	174	20	is	be	AUX
eurjchem-2350	174	21	confirmed	confirm	VERB
eurjchem-2350	174	22	by	by	ADP
eurjchem-2350	174	23	evidence	evidence	NOUN
eurjchem-2350	174	24	from	from	ADP
eurjchem-2350	174	25	randomized	randomized	ADJ
eurjchem-2350	174	26	controlled	control	VERB
eurjchem-2350	174	27	trials	trial	NOUN
eurjchem-2350	174	28	(	(	PUNCT
eurjchem-2350	174	29	rcts	rct	NOUN
eurjchem-2350	174	30	)	)	PUNCT
eurjchem-2350	175	1	[	[	X
eurjchem-2350	175	2	57	57	NUM
eurjchem-2350	175	3	]	]	PUNCT
eurjchem-2350	175	4	.	.	PUNCT
eurjchem-2350	176	1	in	in	ADP
eurjchem-2350	176	2	general	general	ADJ
eurjchem-2350	176	3	,	,	PUNCT
eurjchem-2350	176	4	the	the	DET
eurjchem-2350	176	5	findings	finding	NOUN
eurjchem-2350	176	6	of	of	ADP
eurjchem-2350	176	7	our	our	PRON
eurjchem-2350	176	8	study	study	NOUN
eurjchem-2350	176	9	will	will	AUX
eurjchem-2350	176	10	be	be	AUX
eurjchem-2350	176	11	helpful	helpful	ADJ
eurjchem-2350	176	12	in	in	ADP
eurjchem-2350	176	13	a	a	DET
eurjchem-2350	176	14	short	short	ADJ
eurjchem-2350	176	15	list	list	NOUN
eurjchem-2350	176	16	of	of	ADP
eurjchem-2350	176	17	compounds	compound	NOUN
eurjchem-2350	176	18	to	to	PART
eurjchem-2350	176	19	be	be	AUX
eurjchem-2350	176	20	repurposed	repurpose	VERB
eurjchem-2350	176	21	as	as	ADP
eurjchem-2350	176	22	a	a	DET
eurjchem-2350	176	23	therapeutic	therapeutic	ADJ
eurjchem-2350	176	24	candidate	candidate	NOUN
eurjchem-2350	176	25	against	against	ADP
eurjchem-2350	176	26	mpro	mpro	ADJ
eurjchem-2350	176	27	and	and	CCONJ
eurjchem-2350	176	28	its	its	PRON
eurjchem-2350	176	29	mutants	mutant	NOUN
eurjchem-2350	176	30	.	.	PUNCT
eurjchem-2350	177	1	essential	essential	ADJ
eurjchem-2350	177	2	functional	functional	ADJ
eurjchem-2350	177	3	biological	biological	ADJ
eurjchem-2350	177	4	macromolecules	macromolecule	NOUN
eurjchem-2350	177	5	in	in	ADP
eurjchem-2350	177	6	coronaviruses	coronaviruse	NOUN
eurjchem-2350	177	7	are	be	AUX
eurjchem-2350	177	8	viral	viral	ADJ
eurjchem-2350	177	9	proteases	protease	NOUN
eurjchem-2350	177	10	.	.	PUNCT
eurjchem-2350	178	1	for	for	ADP
eurjchem-2350	178	2	the	the	DET
eurjchem-2350	178	3	effective	effective	ADJ
eurjchem-2350	178	4	treatment	treatment	NOUN
eurjchem-2350	178	5	of	of	ADP
eurjchem-2350	178	6	several	several	ADJ
eurjchem-2350	178	7	viral	viral	ADJ
eurjchem-2350	178	8	diseases	disease	NOUN
eurjchem-2350	178	9	,	,	PUNCT
eurjchem-2350	178	10	these	these	DET
eurjchem-2350	178	11	proteases	protease	NOUN
eurjchem-2350	178	12	have	have	AUX
eurjchem-2350	178	13	been	be	AUX
eurjchem-2350	178	14	considered	consider	VERB
eurjchem-2350	178	15	as	as	ADP
eurjchem-2350	178	16	potential	potential	ADJ
eurjchem-2350	178	17	drug	drug	NOUN
eurjchem-2350	178	18	targets	target	NOUN
eurjchem-2350	178	19	[	[	X
eurjchem-2350	178	20	58	58	NUM
eurjchem-2350	178	21	]	]	PUNCT
eurjchem-2350	178	22	.	.	PUNCT
eurjchem-2350	179	1	therefore	therefore	ADV
eurjchem-2350	179	2	,	,	PUNCT
eurjchem-2350	179	3	protease	protease	NOUN
eurjchem-2350	179	4	inhibitors	inhibitor	NOUN
eurjchem-2350	179	5	comprise	comprise	VERB
eurjchem-2350	179	6	the	the	DET
eurjchem-2350	179	7	majority	majority	NOUN
eurjchem-2350	179	8	of	of	ADP
eurjchem-2350	179	9	reported	report	VERB
eurjchem-2350	179	10	anti	anti	ADJ
eurjchem-2350	179	11	-	-	ADJ
eurjchem-2350	179	12	sars	sar	NOUN
eurjchem-2350	179	13	-	-	PUNCT
eurjchem-2350	179	14	cov-2	cov-2	NOUN
eurjchem-2350	179	15	drugs	drug	NOUN
eurjchem-2350	179	16	.	.	PUNCT
eurjchem-2350	180	1	this	this	PRON
eurjchem-2350	180	2	has	have	AUX
eurjchem-2350	180	3	influenced	influence	VERB
eurjchem-2350	180	4	us	we	PRON
eurjchem-2350	180	5	to	to	PART
eurjchem-2350	180	6	identify	identify	VERB
eurjchem-2350	180	7	the	the	DET
eurjchem-2350	180	8	potential	potential	ADJ
eurjchem-2350	180	9	protease	protease	NOUN
eurjchem-2350	180	10	inhibitors	inhibitor	NOUN
eurjchem-2350	180	11	centered	center	VERB
eurjchem-2350	180	12	on	on	ADP
eurjchem-2350	180	13	the	the	DET
eurjchem-2350	180	14	quinoline	quinoline	ADJ
eurjchem-2350	180	15	moiety	moiety	NOUN
eurjchem-2350	180	16	against	against	ADP
eurjchem-2350	180	17	the	the	DET
eurjchem-2350	180	18	sars	sar	NOUN
eurjchem-2350	180	19	-	-	PUNCT
eurjchem-2350	180	20	cov-2	cov-2	NOUN
eurjchem-2350	180	21	therapeutic	therapeutic	ADJ
eurjchem-2350	180	22	targets	target	NOUN
eurjchem-2350	180	23	using	use	VERB
eurjchem-2350	180	24	an	an	DET
eurjchem-2350	180	25	in	in	ADP
eurjchem-2350	180	26	silico	silico	NOUN
eurjchem-2350	180	27	approach	approach	NOUN
eurjchem-2350	180	28	.	.	PUNCT
eurjchem-2350	181	1	from	from	ADP
eurjchem-2350	181	2	our	our	PRON
eurjchem-2350	181	3	library	library	NOUN
eurjchem-2350	181	4	of	of	ADP
eurjchem-2350	181	5	quinoline	quinoline	NOUN
eurjchem-2350	181	6	compounds	compound	NOUN
eurjchem-2350	181	7	,	,	PUNCT
eurjchem-2350	181	8	a	a	DET
eurjchem-2350	181	9	series	series	NOUN
eurjchem-2350	181	10	of	of	ADP
eurjchem-2350	181	11	ten	ten	NUM
eurjchem-2350	181	12	compounds	compound	NOUN
eurjchem-2350	181	13	were	be	AUX
eurjchem-2350	181	14	subjected	subject	VERB
eurjchem-2350	181	15	to	to	ADP
eurjchem-2350	181	16	in	in	ADP
eurjchem-2350	181	17	silico	silico	NOUN
eurjchem-2350	181	18	analysis	analysis	NOUN
eurjchem-2350	181	19	along	along	ADP
eurjchem-2350	181	20	with	with	ADP
eurjchem-2350	181	21	standard	standard	ADJ
eurjchem-2350	181	22	drug	drug	NOUN
eurjchem-2350	181	23	molecules	molecule	NOUN
eurjchem-2350	181	24	,	,	PUNCT
eurjchem-2350	181	25	hcq	hcq	NOUN
eurjchem-2350	181	26	and	and	CCONJ
eurjchem-2350	181	27	rdv	rdv	NOUN
eurjchem-2350	181	28	,	,	PUNCT
eurjchem-2350	181	29	against	against	ADP
eurjchem-2350	181	30	the	the	DET
eurjchem-2350	181	31	five	five	NUM
eurjchem-2350	181	32	main	main	ADJ
eurjchem-2350	181	33	proteases	protease	NOUN
eurjchem-2350	181	34	of	of	ADP
eurjchem-2350	181	35	covid-19	covid-19	PROPN
eurjchem-2350	181	36	.	.	PUNCT
eurjchem-2350	182	1	among	among	ADP
eurjchem-2350	182	2	the	the	DET
eurjchem-2350	182	3	five	five	NUM
eurjchem-2350	182	4	different	different	ADJ
eurjchem-2350	182	5	main	main	ADJ
eurjchem-2350	182	6	proteases	protease	NOUN
eurjchem-2350	182	7	utilized	utilize	VERB
eurjchem-2350	182	8	to	to	PART
eurjchem-2350	182	9	determine	determine	VERB
eurjchem-2350	182	10	the	the	DET
eurjchem-2350	182	11	active	active	ADJ
eurjchem-2350	182	12	amino	amino	NOUN
eurjchem-2350	182	13	acid	acid	NOUN
eurjchem-2350	182	14	residue	residue	NOUN
eurjchem-2350	182	15	,	,	PUNCT
eurjchem-2350	182	16	glu166	glu166	PROPN
eurjchem-2350	182	17	has	have	AUX
eurjchem-2350	182	18	been	be	AUX
eurjchem-2350	182	19	found	find	VERB
eurjchem-2350	182	20	to	to	PART
eurjchem-2350	182	21	be	be	AUX
eurjchem-2350	182	22	the	the	DET
eurjchem-2350	182	23	most	most	ADV
eurjchem-2350	182	24	important	important	ADJ
eurjchem-2350	182	25	amino	amino	NOUN
eurjchem-2350	182	26	acid	acid	NOUN
eurjchem-2350	182	27	of	of	ADP
eurjchem-2350	182	28	mpro	mpro	ADJ
eurjchem-2350	182	29	which	which	PRON
eurjchem-2350	182	30	interacts	interact	VERB
eurjchem-2350	182	31	with	with	ADP
eurjchem-2350	182	32	the	the	DET
eurjchem-2350	182	33	inhibitor	inhibitor	NOUN
eurjchem-2350	182	34	[	[	X
eurjchem-2350	182	35	59	59	NUM
eurjchem-2350	182	36	]	]	PUNCT
eurjchem-2350	182	37	.	.	PUNCT
eurjchem-2350	183	1	the	the	DET
eurjchem-2350	183	2	center	center	NOUN
eurjchem-2350	183	3	of	of	ADP
eurjchem-2350	183	4	the	the	DET
eurjchem-2350	183	5	active	active	ADJ
eurjchem-2350	183	6	site	site	NOUN
eurjchem-2350	183	7	of	of	ADP
eurjchem-2350	183	8	the	the	DET
eurjchem-2350	183	9	grid	grid	NOUN
eurjchem-2350	183	10	was	be	AUX
eurjchem-2350	183	11	determined	determine	VERB
eurjchem-2350	183	12	and	and	CCONJ
eurjchem-2350	183	13	the	the	DET
eurjchem-2350	183	14	results	result	NOUN
eurjchem-2350	183	15	of	of	ADP
eurjchem-2350	183	16	these	these	DET
eurjchem-2350	183	17	quinolines	quinoline	NOUN
eurjchem-2350	183	18	showed	show	VERB
eurjchem-2350	183	19	a	a	DET
eurjchem-2350	183	20	better	well	ADJ
eurjchem-2350	183	21	binding	bind	VERB
eurjchem-2350	183	22	energy	energy	NOUN
eurjchem-2350	183	23	and	and	CCONJ
eurjchem-2350	183	24	hydrogen	hydrogen	NOUN
eurjchem-2350	183	25	bond	bond	NOUN
eurjchem-2350	183	26	formation	formation	NOUN
eurjchem-2350	183	27	,	,	PUNCT
eurjchem-2350	183	28	indicating	indicate	VERB
eurjchem-2350	183	29	that	that	SCONJ
eurjchem-2350	183	30	the	the	DET
eurjchem-2350	183	31	quinoline	quinoline	NOUN
eurjchem-2350	183	32	analogues	analogue	NOUN
eurjchem-2350	183	33	q4	q4	PROPN
eurjchem-2350	183	34	,	,	PUNCT
eurjchem-2350	183	35	q6	q6	PROPN
eurjchem-2350	183	36	,	,	PUNCT
eurjchem-2350	183	37	q8	q8	PROPN
eurjchem-2350	183	38	,	,	PUNCT
eurjchem-2350	183	39	q9	q9	PROPN
eurjchem-2350	183	40	and	and	CCONJ
eurjchem-2350	183	41	q10	q10	PROPN
eurjchem-2350	183	42	have	have	VERB
eurjchem-2350	183	43	a	a	DET
eurjchem-2350	183	44	significantly	significantly	ADV
eurjchem-2350	183	45	higher	high	ADJ
eurjchem-2350	183	46	binding	bind	VERB
eurjchem-2350	183	47	interaction	interaction	NOUN
eurjchem-2350	183	48	with	with	ADP
eurjchem-2350	183	49	all	all	DET
eurjchem-2350	183	50	receptors	receptor	NOUN
eurjchem-2350	183	51	compared	compare	VERB
eurjchem-2350	183	52	to	to	ADP
eurjchem-2350	183	53	hcq	hcq	NOUN
eurjchem-2350	183	54	and	and	CCONJ
eurjchem-2350	183	55	rdv	rdv	VERB
eurjchem-2350	183	56	.	.	PUNCT
eurjchem-2350	184	1	among	among	ADP
eurjchem-2350	184	2	these	these	DET
eurjchem-2350	184	3	quinoline	quinoline	NOUN
eurjchem-2350	184	4	molecules	molecule	NOUN
eurjchem-2350	184	5	,	,	PUNCT
eurjchem-2350	184	6	q9	q9	PROPN
eurjchem-2350	184	7	was	be	AUX
eurjchem-2350	184	8	found	find	VERB
eurjchem-2350	184	9	to	to	PART
eurjchem-2350	184	10	be	be	AUX
eurjchem-2350	184	11	a	a	DET
eurjchem-2350	184	12	highly	highly	ADV
eurjchem-2350	184	13	potent	potent	ADJ
eurjchem-2350	184	14	lead	lead	NOUN
eurjchem-2350	184	15	molecule	molecule	NOUN
eurjchem-2350	184	16	with	with	ADP
eurjchem-2350	184	17	significant	significant	ADJ
eurjchem-2350	184	18	binding	bind	VERB
eurjchem-2350	184	19	interactions	interaction	NOUN
eurjchem-2350	184	20	with	with	ADP
eurjchem-2350	184	21	all	all	DET
eurjchem-2350	184	22	target	target	NOUN
eurjchem-2350	184	23	receptors	receptor	NOUN
eurjchem-2350	184	24	of	of	ADP
eurjchem-2350	184	25	sars	sar	NOUN
eurjchem-2350	184	26	-	-	PUNCT
eurjchem-2350	184	27	cov-2	cov-2	NOUN
eurjchem-2350	184	28	.	.	PUNCT
eurjchem-2350	185	1	these	these	DET
eurjchem-2350	185	2	interaction	interaction	NOUN
eurjchem-2350	185	3	parameters	parameter	NOUN
eurjchem-2350	185	4	are	be	AUX
eurjchem-2350	185	5	in	in	ADP
eurjchem-2350	185	6	good	good	ADJ
eurjchem-2350	185	7	agreement	agreement	NOUN
eurjchem-2350	185	8	with	with	ADP
eurjchem-2350	185	9	the	the	DET
eurjchem-2350	185	10	current	current	ADJ
eurjchem-2350	185	11	evidence	evidence	NOUN
eurjchem-2350	185	12	to	to	PART
eurjchem-2350	185	13	indicate	indicate	VERB
eurjchem-2350	185	14	a	a	DET
eurjchem-2350	185	15	good	good	ADJ
eurjchem-2350	185	16	pharmacokinetics	pharmacokinetic	NOUN
eurjchem-2350	185	17	profile	profile	NOUN
eurjchem-2350	185	18	.	.	PUNCT
eurjchem-2350	186	1	furthermore	furthermore	ADV
eurjchem-2350	186	2	,	,	PUNCT
eurjchem-2350	186	3	the	the	DET
eurjchem-2350	186	4	md	md	PROPN
eurjchem-2350	186	5	studies	study	NOUN
eurjchem-2350	186	6	performed	perform	VERB
eurjchem-2350	186	7	in	in	ADP
eurjchem-2350	186	8	this	this	DET
eurjchem-2350	186	9	study	study	NOUN
eurjchem-2350	186	10	for	for	ADP
eurjchem-2350	186	11	the	the	DET
eurjchem-2350	186	12	highly	highly	ADV
eurjchem-2350	186	13	potent	potent	ADJ
eurjchem-2350	186	14	drug	drug	NOUN
eurjchem-2350	186	15	candidate	candidate	NOUN
eurjchem-2350	186	16	q9	q9	PROPN
eurjchem-2350	186	17	also	also	ADV
eurjchem-2350	186	18	proved	prove	VERB
eurjchem-2350	186	19	that	that	SCONJ
eurjchem-2350	186	20	the	the	DET
eurjchem-2350	186	21	binding	bind	VERB
eurjchem-2350	186	22	conformational	conformational	ADJ
eurjchem-2350	186	23	stability	stability	NOUN
eurjchem-2350	186	24	with	with	ADP
eurjchem-2350	186	25	sars	sar	NOUN
eurjchem-2350	186	26	-	-	PUNCT
eurjchem-2350	186	27	cov-2	cov-2	NOUN
eurjchem-2350	186	28	mpro	mpro	ADJ
eurjchem-2350	186	29	(	(	PUNCT
eurjchem-2350	186	30	pdb	pdb	NOUN
eurjchem-2350	186	31	i	i	PROPN
eurjchem-2350	186	32	d	d	PROPN
eurjchem-2350	186	33	6lu7	6lu7	NUM
eurjchem-2350	186	34	)	)	PUNCT
eurjchem-2350	186	35	does	do	AUX
eurjchem-2350	186	36	not	not	PART
eurjchem-2350	186	37	change	change	VERB
eurjchem-2350	186	38	its	its	PRON
eurjchem-2350	186	39	nature	nature	NOUN
eurjchem-2350	186	40	.	.	PUNCT
eurjchem-2350	187	1	the	the	DET
eurjchem-2350	187	2	results	result	NOUN
eurjchem-2350	187	3	of	of	ADP
eurjchem-2350	187	4	our	our	PRON
eurjchem-2350	187	5	admet	admet	NOUN
eurjchem-2350	187	6	analysis	analysis	NOUN
eurjchem-2350	187	7	are	be	AUX
eurjchem-2350	187	8	also	also	ADV
eurjchem-2350	187	9	useful	useful	ADJ
eurjchem-2350	187	10	in	in	ADP
eurjchem-2350	187	11	providing	provide	VERB
eurjchem-2350	187	12	insights	insight	NOUN
eurjchem-2350	187	13	into	into	ADP
eurjchem-2350	187	14	the	the	DET
eurjchem-2350	187	15	structural	structural	ADJ
eurjchem-2350	187	16	criteria	criterion	NOUN
eurjchem-2350	187	17	for	for	ADP
eurjchem-2350	187	18	synthesizing	synthesize	VERB
eurjchem-2350	187	19	a	a	DET
eurjchem-2350	187	20	new	new	ADJ
eurjchem-2350	187	21	potential	potential	ADJ
eurjchem-2350	187	22	drug	drug	NOUN
eurjchem-2350	187	23	molecule	molecule	NOUN
eurjchem-2350	187	24	with	with	ADP
eurjchem-2350	187	25	a	a	DET
eurjchem-2350	187	26	better	well	ADJ
eurjchem-2350	187	27	inhibitory	inhibitory	ADJ
eurjchem-2350	187	28	activity	activity	NOUN
eurjchem-2350	187	29	against	against	ADP
eurjchem-2350	187	30	covid-19	covid-19	PROPN
eurjchem-2350	188	1	[	[	X
eurjchem-2350	188	2	60	60	NUM
eurjchem-2350	188	3	,	,	PUNCT
eurjchem-2350	188	4	61	61	NUM
eurjchem-2350	188	5	]	]	PUNCT
eurjchem-2350	188	6	.	.	PUNCT
eurjchem-2350	189	1	overall	overall	ADV
eurjchem-2350	189	2	,	,	PUNCT
eurjchem-2350	189	3	the	the	DET
eurjchem-2350	189	4	present	present	ADJ
eurjchem-2350	189	5	work	work	NOUN
eurjchem-2350	189	6	should	should	AUX
eurjchem-2350	189	7	lead	lead	VERB
eurjchem-2350	189	8	to	to	ADP
eurjchem-2350	189	9	the	the	DET
eurjchem-2350	189	10	identification	identification	NOUN
eurjchem-2350	189	11	of	of	ADP
eurjchem-2350	189	12	novel	novel	NOUN
eurjchem-2350	189	13	,	,	PUNCT
eurjchem-2350	189	14	less	less	ADV
eurjchem-2350	189	15	toxic	toxic	ADJ
eurjchem-2350	189	16	,	,	PUNCT
eurjchem-2350	189	17	and	and	CCONJ
eurjchem-2350	189	18	highly	highly	ADV
eurjchem-2350	189	19	efficient	efficient	ADJ
eurjchem-2350	189	20	quinoline	quinoline	NOUN
eurjchem-2350	189	21	derivatives	derivative	NOUN
eurjchem-2350	189	22	for	for	ADP
eurjchem-2350	189	23	chemical	chemical	NOUN
eurjchem-2350	189	24	interventions	intervention	NOUN
eurjchem-2350	189	25	to	to	PART
eurjchem-2350	189	26	manage	manage	VERB
eurjchem-2350	189	27	covid-19	covid-19	PROPN
eurjchem-2350	189	28	infections	infection	NOUN
eurjchem-2350	189	29	.	.	PUNCT
eurjchem-2350	190	1	the	the	DET
eurjchem-2350	190	2	use	use	NOUN
eurjchem-2350	190	3	of	of	ADP
eurjchem-2350	190	4	bioinformatic	bioinformatic	ADJ
eurjchem-2350	190	5	tools	tool	NOUN
eurjchem-2350	190	6	should	should	AUX
eurjchem-2350	190	7	be	be	AUX
eurjchem-2350	190	8	helpful	helpful	ADJ
eurjchem-2350	190	9	in	in	ADP
eurjchem-2350	190	10	designing	design	VERB
eurjchem-2350	190	11	and	and	CCONJ
eurjchem-2350	190	12	synthesizing	synthesize	VERB
eurjchem-2350	190	13	more	more	ADV
eurjchem-2350	190	14	appropriate	appropriate	ADJ
eurjchem-2350	190	15	molecules	molecule	NOUN
eurjchem-2350	190	16	which	which	PRON
eurjchem-2350	190	17	can	can	AUX
eurjchem-2350	190	18	interact	interact	VERB
eurjchem-2350	190	19	better	well	ADV
eurjchem-2350	190	20	with	with	ADP
eurjchem-2350	190	21	specific	specific	ADJ
eurjchem-2350	190	22	receptors	receptor	NOUN
eurjchem-2350	190	23	by	by	ADP
eurjchem-2350	190	24	the	the	DET
eurjchem-2350	190	25	combinatorial	combinatorial	ADJ
eurjchem-2350	190	26	approach	approach	NOUN
eurjchem-2350	190	27	.	.	PUNCT
eurjchem-2350	191	1	disclosure	disclosure	NOUN
eurjchem-2350	191	2	statement	statement	NOUN
eurjchem-2350	191	3	conflict	conflict	NOUN
eurjchem-2350	191	4	of	of	ADP
eurjchem-2350	191	5	interest	interest	NOUN
eurjchem-2350	191	6	:	:	PUNCT
eurjchem-2350	191	7	all	all	DET
eurjchem-2350	191	8	authors	author	NOUN
eurjchem-2350	191	9	declare	declare	VERB
eurjchem-2350	191	10	that	that	SCONJ
eurjchem-2350	191	11	there	there	PRON
eurjchem-2350	191	12	are	be	VERB
eurjchem-2350	191	13	no	no	DET
eurjchem-2350	191	14	conflicts	conflict	NOUN
eurjchem-2350	191	15	of	of	ADP
eurjchem-2350	191	16	interest	interest	NOUN
eurjchem-2350	191	17	associated	associate	VERB
eurjchem-2350	191	18	with	with	ADP
eurjchem-2350	191	19	the	the	DET
eurjchem-2350	191	20	publication	publication	NOUN
eurjchem-2350	191	21	of	of	ADP
eurjchem-2350	191	22	this	this	DET
eurjchem-2350	191	23	manuscript	manuscript	NOUN
eurjchem-2350	191	24	.	.	PUNCT
eurjchem-2350	192	1	data	datum	NOUN
eurjchem-2350	192	2	availability	availability	NOUN
eurjchem-2350	192	3	:	:	PUNCT
eurjchem-2350	192	4	all	all	DET
eurjchem-2350	192	5	data	datum	NOUN
eurjchem-2350	192	6	generated	generate	VERB
eurjchem-2350	192	7	or	or	CCONJ
eurjchem-2350	192	8	the	the	DET
eurjchem-2350	192	9	molecules	molecule	NOUN
eurjchem-2350	192	10	used	use	VERB
eurjchem-2350	192	11	during	during	ADP
eurjchem-2350	192	12	the	the	DET
eurjchem-2350	192	13	current	current	ADJ
eurjchem-2350	192	14	study	study	NOUN
eurjchem-2350	192	15	are	be	AUX
eurjchem-2350	192	16	available	available	ADJ
eurjchem-2350	192	17	from	from	ADP
eurjchem-2350	192	18	the	the	DET
eurjchem-2350	192	19	corresponding	corresponding	ADJ
eurjchem-2350	192	20	author	author	NOUN
eurjchem-2350	192	21	on	on	ADP
eurjchem-2350	192	22	a	a	DET
eurjchem-2350	192	23	reasonable	reasonable	ADJ
eurjchem-2350	192	24	request	request	NOUN
eurjchem-2350	192	25	.	.	PUNCT
eurjchem-2350	193	1	credit	credit	NOUN
eurjchem-2350	193	2	authorship	authorship	NOUN
eurjchem-2350	193	3	contribution	contribution	NOUN
eurjchem-2350	193	4	statement	statement	NOUN
eurjchem-2350	193	5	conceptualization	conceptualization	NOUN
eurjchem-2350	193	6	:	:	PUNCT
eurjchem-2350	193	7	praveen	praveen	PROPN
eurjchem-2350	193	8	kumar	kumar	PROPN
eurjchem-2350	193	9	,	,	PUNCT
eurjchem-2350	193	10	rajeshwara	rajeshwara	PROPN
eurjchem-2350	193	11	achur	achur	NOUN
eurjchem-2350	193	12	;	;	PUNCT
eurjchem-2350	193	13	methodology	methodology	NOUN
eurjchem-2350	193	14	:	:	PUNCT
eurjchem-2350	193	15	praveen	praveen	PROPN
eurjchem-2350	193	16	kumar	kumar	PROPN
eurjchem-2350	193	17	,	,	PUNCT
eurjchem-2350	193	18	rajeshwara	rajeshwara	PROPN
eurjchem-2350	193	19	achur	achur	NOUN
eurjchem-2350	193	20	;	;	PUNCT
eurjchem-2350	193	21	software	software	NOUN
eurjchem-2350	193	22	:	:	PUNCT
eurjchem-2350	193	23	praveen	praveen	PROPN
eurjchem-2350	193	24	kumar	kumar	PROPN
eurjchem-2350	193	25	,	,	PUNCT
eurjchem-2350	193	26	sakthivel	sakthivel	NOUN
eurjchem-2350	193	27	balasubramaniyan	balasubramaniyan	NOUN
eurjchem-2350	193	28	;	;	PUNCT
eurjchem-2350	193	29	validation	validation	NOUN
eurjchem-2350	193	30	:	:	PUNCT
eurjchem-2350	193	31	praveen	praveen	PROPN
eurjchem-2350	193	32	kumar	kumar	PROPN
eurjchem-2350	193	33	,	,	PUNCT
eurjchem-2350	193	34	rajeshwara	rajeshwara	PROPN
eurjchem-2350	193	35	achur	achur	PROPN
eurjchem-2350	193	36	,	,	PUNCT
eurjchem-2350	193	37	nayak	nayak	PROPN
eurjchem-2350	193	38	devappa	devappa	PROPN
eurjchem-2350	193	39	satyanarayan	satyanarayan	PROPN
eurjchem-2350	193	40	;	;	PUNCT
eurjchem-2350	193	41	formal	formal	ADJ
eurjchem-2350	193	42	analysis	analysis	NOUN
eurjchem-2350	193	43	:	:	PUNCT
eurjchem-2350	193	44	rajeshwara	rajeshwara	PROPN
eurjchem-2350	193	45	achur	achur	PROPN
eurjchem-2350	193	46	,	,	PUNCT
eurjchem-2350	193	47	nayak	nayak	PROPN
eurjchem-2350	193	48	devappa	devappa	PROPN
eurjchem-2350	193	49	satyanarayan	satyanarayan	PROPN
eurjchem-2350	193	50	,	,	PUNCT
eurjchem-2350	193	51	praveen	praveen	PROPN
eurjchem-2350	193	52	kumar	kumar	PROPN
eurjchem-2350	193	53	;	;	PUNCT
eurjchem-2350	193	54	investigation	investigation	NOUN
eurjchem-2350	193	55	:	:	PUNCT
eurjchem-2350	193	56	praveen	praveen	PROPN
eurjchem-2350	193	57	kumar	kumar	PROPN
eurjchem-2350	193	58	,	,	PUNCT
eurjchem-2350	193	59	rajeshwara	rajeshwara	PROPN
eurjchem-2350	193	60	achur	achur	NOUN
eurjchem-2350	193	61	;	;	PUNCT
eurjchem-2350	193	62	resources	resource	NOUN
eurjchem-2350	193	63	:	:	PUNCT
eurjchem-2350	193	64	nayak	nayak	PROPN
eurjchem-2350	193	65	devappa	devappa	PROPN
eurjchem-2350	193	66	satyanarayan	satyanarayan	PROPN
eurjchem-2350	193	67	,	,	PUNCT
eurjchem-2350	193	68	rajeshwara	rajeshwara	PROPN
eurjchem-2350	193	69	achur	achur	NOUN
eurjchem-2350	193	70	,	,	PUNCT
eurjchem-2350	193	71	santhosha	santhosha	PROPN
eurjchem-2350	193	72	sangapurada	sangapurada	PROPN
eurjchem-2350	193	73	mahantheshappa	mahantheshappa	PROPN
eurjchem-2350	193	74	;	;	PUNCT
eurjchem-2350	193	75	data	data	NOUN
eurjchem-2350	193	76	curation	curation	NOUN
eurjchem-2350	193	77	:	:	PUNCT
eurjchem-2350	193	78	praveen	praveen	PROPN
eurjchem-2350	193	79	kumar	kumar	PROPN
eurjchem-2350	193	80	,	,	PUNCT
eurjchem-2350	193	81	rajeshwara	rajeshwara	PROPN
eurjchem-2350	193	82	achur	achur	NOUN
eurjchem-2350	193	83	;	;	PUNCT
eurjchem-2350	193	84	writing	write	VERB
eurjchem-2350	193	85	original	original	ADJ
eurjchem-2350	193	86	draft	draft	NOUN
eurjchem-2350	193	87	:	:	PUNCT
eurjchem-2350	193	88	praveen	praveen	PROPN
eurjchem-2350	193	89	kumar	kumar	PROPN
eurjchem-2350	193	90	;	;	PUNCT
eurjchem-2350	193	91	writing	write	VERB
eurjchem-2350	193	92	review	review	NOUN
eurjchem-2350	193	93	and	and	CCONJ
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eurjchem-2350	193	95	:	:	PUNCT
eurjchem-2350	193	96	rajeshwara	rajeshwara	PROPN
eurjchem-2350	193	97	achur	achur	PROPN
eurjchem-2350	193	98	,	,	PUNCT
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eurjchem-2350	193	102	;	;	PUNCT
eurjchem-2350	193	103	visualization	visualization	NOUN
eurjchem-2350	193	104	:	:	PUNCT
eurjchem-2350	194	1	praveen	praveen	PROPN
eurjchem-2350	194	2	kumar	kumar	PROPN
eurjchem-2350	194	3	,	,	PUNCT
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eurjchem-2350	194	6	;	;	PUNCT
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eurjchem-2350	194	9	:	:	PUNCT
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eurjchem-2350	194	22	;	;	PUNCT
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eurjchem-2350	194	24	:	:	PUNCT
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eurjchem-2350	194	26	achur	achur	PROPN
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eurjchem-2350	196	1	praveen	praveen	PROPN
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eurjchem-2350	197	7	sakthivel	sakthivel	PROPN
eurjchem-2350	197	8	balasubramaniyan	balasubramaniyan	PROPN
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eurjchem-2350	198	2	rajeshwara	rajeshwara	PROPN
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eurjchem-2350	199	4	1	1	NUM
eurjchem-2350	199	5	]	]	PUNCT
eurjchem-2350	199	6	.	.	PUNCT
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eurjchem-2350	200	2	,	,	PUNCT
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eurjchem-2350	200	4	;	;	PUNCT
eurjchem-2350	200	5	ding	ding	NOUN
eurjchem-2350	200	6	,	,	PUNCT
eurjchem-2350	200	7	y.	y.	PROPN
eurjchem-2350	200	8	;	;	PUNCT
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eurjchem-2350	200	10	,	,	PUNCT
eurjchem-2350	200	11	z.	z.	PROPN
eurjchem-2350	200	12	;	;	PUNCT
eurjchem-2350	200	13	pu	pu	PROPN
eurjchem-2350	200	14	,	,	PUNCT
eurjchem-2350	200	15	r.	r.	PROPN
eurjchem-2350	200	16	;	;	PUNCT
eurjchem-2350	200	17	li	li	PROPN
eurjchem-2350	200	18	,	,	PUNCT
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eurjchem-2350	200	20	;	;	PUNCT
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eurjchem-2350	200	22	,	,	PUNCT
eurjchem-2350	200	23	j.	j.	PROPN
eurjchem-2350	200	24	;	;	PUNCT
eurjchem-2350	200	25	liu	liu	PROPN
eurjchem-2350	200	26	,	,	PUNCT
eurjchem-2350	200	27	j.	j.	PROPN
eurjchem-2350	200	28	;	;	PUNCT
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eurjchem-2350	200	30	,	,	PUNCT
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eurjchem-2350	200	32	;	;	PUNCT
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eurjchem-2350	200	35	l.	l.	PROPN
eurjchem-2350	200	36	;	;	PUNCT
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eurjchem-2350	200	38	,	,	PUNCT
eurjchem-2350	200	39	l.	l.	PROPN
eurjchem-2350	200	40	;	;	PUNCT
eurjchem-2350	200	41	jiang	jiang	PROPN
eurjchem-2350	200	42	,	,	PUNCT
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eurjchem-2350	200	44	;	;	PUNCT
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eurjchem-2350	200	46	,	,	PUNCT
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eurjchem-2350	200	48	;	;	PUNCT
eurjchem-2350	200	49	zhao	zhao	PROPN
eurjchem-2350	200	50	,	,	PUNCT
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eurjchem-2350	200	52	;	;	PUNCT
eurjchem-2350	200	53	zhang	zhang	PROPN
eurjchem-2350	200	54	,	,	PUNCT
eurjchem-2350	200	55	d.	d.	PROPN
eurjchem-2350	200	56	;	;	PUNCT
eurjchem-2350	200	57	zhao	zhao	PROPN
eurjchem-2350	200	58	,	,	PUNCT
eurjchem-2350	200	59	p.	p.	PROPN
eurjchem-2350	200	60	;	;	PUNCT
eurjchem-2350	200	61	yu	yu	PROPN
eurjchem-2350	200	62	,	,	PUNCT
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eurjchem-2350	200	64	;	;	PUNCT
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eurjchem-2350	200	67	z.	z.	PROPN
eurjchem-2350	200	68	;	;	PUNCT
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eurjchem-2350	200	71	z.	z.	PROPN
eurjchem-2350	200	72	;	;	PUNCT
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eurjchem-2350	200	74	,	,	PUNCT
eurjchem-2350	200	75	z.	z.	PROPN
eurjchem-2350	200	76	;	;	PUNCT
eurjchem-2350	200	77	xi	xi	PROPN
eurjchem-2350	200	78	,	,	PUNCT
eurjchem-2350	200	79	q.	q.	PROPN
eurjchem-2350	200	80	;	;	PUNCT
eurjchem-2350	200	81	zhao	zhao	PROPN
eurjchem-2350	200	82	,	,	PUNCT
eurjchem-2350	200	83	d.	d.	PROPN
eurjchem-2350	200	84	;	;	PUNCT
eurjchem-2350	200	85	yu	yu	PROPN
eurjchem-2350	200	86	,	,	PUNCT
eurjchem-2350	200	87	p.	p.	PROPN
eurjchem-2350	200	88	;	;	PUNCT
eurjchem-2350	200	89	zhu	zhu	PROPN
eurjchem-2350	200	90	,	,	PUNCT
eurjchem-2350	200	91	c.	c.	PROPN
eurjchem-2350	200	92	;	;	PUNCT
eurjchem-2350	200	93	chen	chen	PROPN
eurjchem-2350	200	94	,	,	PUNCT
eurjchem-2350	200	95	z.	z.	PROPN
eurjchem-2350	200	96	;	;	PUNCT
eurjchem-2350	200	97	zhang	zhang	PROPN
eurjchem-2350	200	98	,	,	PUNCT
eurjchem-2350	200	99	s.	s.	PROPN
eurjchem-2350	200	100	;	;	PUNCT
eurjchem-2350	200	101	ji	ji	PROPN
eurjchem-2350	200	102	,	,	PUNCT
eurjchem-2350	200	103	j.	j.	PROPN
eurjchem-2350	200	104	;	;	PUNCT
eurjchem-2350	200	105	cao	cao	PROPN
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eurjchem-2350	200	116	of	of	ADP
eurjchem-2350	200	117	covid-19	covid-19	PROPN
eurjchem-2350	200	118	patients	patient	NOUN
eurjchem-2350	200	119	with	with	ADP
eurjchem-2350	200	120	and	and	CCONJ
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eurjchem-2350	200	123	in	in	ADP
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eurjchem-2350	201	2	,	,	PUNCT
eurjchem-2350	201	3	2020	2020	NUM
eurjchem-2350	201	4	.	.	PUNCT
eurjchem-2350	202	1	https://doi.org/10.1101/2020.02.28.20028068	https://doi.org/10.1101/2020.02.28.20028068	VERB
eurjchem-2350	202	2	.	.	PUNCT
eurjchem-2350	203	1	[	[	X
eurjchem-2350	203	2	2	2	NUM
eurjchem-2350	203	3	]	]	PUNCT
eurjchem-2350	203	4	.	.	PUNCT
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eurjchem-2350	204	2	,	,	PUNCT
eurjchem-2350	204	3	d.	d.	PROPN
eurjchem-2350	204	4	l.	l.	PROPN
eurjchem-2350	204	5	;	;	PUNCT
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eurjchem-2350	204	7	,	,	PUNCT
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eurjchem-2350	204	9	;	;	PUNCT
eurjchem-2350	204	10	shah	shah	PROPN
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eurjchem-2350	204	12	s.	s.	PROPN
eurjchem-2350	204	13	i.	i.	PROPN
eurjchem-2350	204	14	;	;	PUNCT
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eurjchem-2350	204	19	;	;	PUNCT
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eurjchem-2350	204	23	.	.	PUNCT
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eurjchem-2350	205	8	from	from	ADP
eurjchem-2350	205	9	covid-19	covid-19	PROPN
eurjchem-2350	205	10	research	research	NOUN
eurjchem-2350	205	11	,	,	PUNCT
eurjchem-2350	205	12	implications	implication	NOUN
eurjchem-2350	205	13	for	for	ADP
eurjchem-2350	205	14	pediatric	pediatric	ADJ
eurjchem-2350	205	15	research	research	NOUN
eurjchem-2350	205	16	.	.	PUNCT
eurjchem-2350	206	1	pediatr	pediatr	PROPN
eurjchem-2350	206	2	.	.	PUNCT
eurjchem-2350	207	1	res	re	NOUN
eurjchem-2350	207	2	.	.	PUNCT
eurjchem-2350	208	1	2020	2020	NUM
eurjchem-2350	208	2	,	,	PUNCT
eurjchem-2350	208	3	88	88	NUM
eurjchem-2350	208	4	(	(	PUNCT
eurjchem-2350	208	5	2	2	NUM
eurjchem-2350	208	6	)	)	PUNCT
eurjchem-2350	208	7	,	,	PUNCT
eurjchem-2350	208	8	148–150	148–150	NUM
eurjchem-2350	208	9	.	.	PUNCT
eurjchem-2350	209	1	[	[	X
eurjchem-2350	209	2	3	3	NUM
eurjchem-2350	209	3	]	]	PUNCT
eurjchem-2350	209	4	.	.	PUNCT
eurjchem-2350	210	1	smyth	smyth	NOUN
eurjchem-2350	210	2	,	,	PUNCT
eurjchem-2350	210	3	t.	t.	PROPN
eurjchem-2350	210	4	;	;	PUNCT
eurjchem-2350	210	5	ramachandran	ramachandran	PROPN
eurjchem-2350	210	6	,	,	PUNCT
eurjchem-2350	210	7	v.	v.	ADP
eurjchem-2350	210	8	n.	n.	NOUN
eurjchem-2350	210	9	;	;	PUNCT
eurjchem-2350	210	10	smyth	smyth	PROPN
eurjchem-2350	210	11	,	,	PUNCT
eurjchem-2350	210	12	w.	w.	PROPN
eurjchem-2350	210	13	f.	f.	PROPN
eurjchem-2350	211	1	a	a	DET
eurjchem-2350	211	2	study	study	NOUN
eurjchem-2350	211	3	of	of	ADP
eurjchem-2350	211	4	the	the	DET
eurjchem-2350	211	5	antimicrobial	antimicrobial	ADJ
eurjchem-2350	211	6	activity	activity	NOUN
eurjchem-2350	211	7	of	of	ADP
eurjchem-2350	211	8	selected	select	VERB
eurjchem-2350	211	9	naturally	naturally	ADV
eurjchem-2350	211	10	occurring	occur	VERB
eurjchem-2350	211	11	and	and	CCONJ
eurjchem-2350	211	12	synthetic	synthetic	ADJ
eurjchem-2350	211	13	coumarins	coumarin	NOUN
eurjchem-2350	211	14	.	.	PUNCT
eurjchem-2350	212	1	int	int	NOUN
eurjchem-2350	212	2	.	.	PUNCT
eurjchem-2350	213	1	j.	j.	PROPN
eurjchem-2350	213	2	antimicrob	antimicrob	PROPN
eurjchem-2350	213	3	.	.	PUNCT
eurjchem-2350	214	1	agents	agent	NOUN
eurjchem-2350	214	2	2009	2009	NUM
eurjchem-2350	214	3	,	,	PUNCT
eurjchem-2350	214	4	33	33	NUM
eurjchem-2350	214	5	(	(	PUNCT
eurjchem-2350	214	6	5	5	NUM
eurjchem-2350	214	7	)	)	PUNCT
eurjchem-2350	214	8	,	,	PUNCT
eurjchem-2350	214	9	421–426	421–426	NUM
eurjchem-2350	214	10	.	.	PUNCT
eurjchem-2350	215	1	[	[	X
eurjchem-2350	215	2	4	4	NUM
eurjchem-2350	215	3	]	]	PUNCT
eurjchem-2350	215	4	.	.	PUNCT
eurjchem-2350	216	1	yazdany	yazdany	PROPN
eurjchem-2350	216	2	,	,	PUNCT
eurjchem-2350	216	3	j.	j.	PROPN
eurjchem-2350	216	4	;	;	PUNCT
eurjchem-2350	216	5	kim	kim	PROPN
eurjchem-2350	216	6	,	,	PUNCT
eurjchem-2350	216	7	a.	a.	PROPN
eurjchem-2350	216	8	h.	h.	PROPN
eurjchem-2350	216	9	j.	j.	PROPN
eurjchem-2350	216	10	use	use	PROPN
eurjchem-2350	216	11	of	of	ADP
eurjchem-2350	216	12	hydroxychloroquine	hydroxychloroquine	NOUN
eurjchem-2350	216	13	and	and	CCONJ
eurjchem-2350	216	14	chloroquine	chloroquine	NOUN
eurjchem-2350	216	15	during	during	ADP
eurjchem-2350	216	16	the	the	DET
eurjchem-2350	216	17	covid-19	covid-19	PROPN
eurjchem-2350	216	18	pandemic	pandemic	NOUN
eurjchem-2350	216	19	:	:	PUNCT
eurjchem-2350	216	20	what	what	PRON
eurjchem-2350	216	21	every	every	DET
eurjchem-2350	216	22	clinician	clinician	NOUN
eurjchem-2350	216	23	should	should	AUX
eurjchem-2350	216	24	know	know	VERB
eurjchem-2350	216	25	.	.	PUNCT
eurjchem-2350	217	1	ann	ann	PROPN
eurjchem-2350	217	2	.	.	PUNCT
eurjchem-2350	217	3	intern	intern	PROPN
eurjchem-2350	217	4	.	.	PUNCT
eurjchem-2350	218	1	med	med	PROPN
eurjchem-2350	218	2	.	.	PUNCT
eurjchem-2350	219	1	2020	2020	NUM
eurjchem-2350	219	2	,	,	PUNCT
eurjchem-2350	219	3	172	172	NUM
eurjchem-2350	219	4	(	(	PUNCT
eurjchem-2350	219	5	11	11	NUM
eurjchem-2350	219	6	)	)	PUNCT
eurjchem-2350	219	7	,	,	PUNCT
eurjchem-2350	219	8	754–755	754–755	NUM
eurjchem-2350	219	9	.	.	PUNCT
eurjchem-2350	220	1	[	[	X
eurjchem-2350	220	2	5	5	NUM
eurjchem-2350	220	3	]	]	PUNCT
eurjchem-2350	220	4	.	.	PUNCT
eurjchem-2350	220	5	wang	wang	PROPN
eurjchem-2350	220	6	,	,	PUNCT
eurjchem-2350	220	7	m.	m.	NOUN
eurjchem-2350	220	8	;	;	PUNCT
eurjchem-2350	220	9	cao	cao	PROPN
eurjchem-2350	220	10	,	,	PUNCT
eurjchem-2350	220	11	r.	r.	PROPN
eurjchem-2350	220	12	;	;	PUNCT
eurjchem-2350	220	13	zhang	zhang	PROPN
eurjchem-2350	220	14	,	,	PUNCT
eurjchem-2350	220	15	l.	l.	PROPN
eurjchem-2350	220	16	;	;	PUNCT
eurjchem-2350	220	17	yang	yang	PROPN
eurjchem-2350	220	18	,	,	PUNCT
eurjchem-2350	220	19	x.	x.	PROPN
eurjchem-2350	220	20	;	;	PUNCT
eurjchem-2350	220	21	liu	liu	PROPN
eurjchem-2350	220	22	,	,	PUNCT
eurjchem-2350	220	23	j.	j.	PROPN
eurjchem-2350	220	24	;	;	PUNCT
eurjchem-2350	220	25	xu	xu	PROPN
eurjchem-2350	220	26	,	,	PUNCT
eurjchem-2350	220	27	m.	m.	NOUN
eurjchem-2350	220	28	;	;	PUNCT
eurjchem-2350	220	29	shi	shi	PROPN
eurjchem-2350	220	30	,	,	PUNCT
eurjchem-2350	220	31	z.	z.	PROPN
eurjchem-2350	220	32	;	;	PUNCT
eurjchem-2350	220	33	hu	hu	PROPN
eurjchem-2350	220	34	,	,	PUNCT
eurjchem-2350	220	35	z.	z.	PROPN
eurjchem-2350	220	36	;	;	PUNCT
eurjchem-2350	220	37	zhong	zhong	PROPN
eurjchem-2350	220	38	,	,	PUNCT
eurjchem-2350	220	39	w.	w.	PROPN
eurjchem-2350	220	40	;	;	PUNCT
eurjchem-2350	220	41	xiao	xiao	PROPN
eurjchem-2350	220	42	,	,	PUNCT
eurjchem-2350	220	43	g.	g.	PROPN
eurjchem-2350	220	44	remdesivir	remdesivir	PROPN
eurjchem-2350	220	45	and	and	CCONJ
eurjchem-2350	220	46	chloroquine	chloroquine	NOUN
eurjchem-2350	220	47	effectively	effectively	ADV
eurjchem-2350	220	48	inhibit	inhibit	VERB
eurjchem-2350	220	49	the	the	DET
eurjchem-2350	220	50	recently	recently	ADV
eurjchem-2350	220	51	emerged	emerge	VERB
eurjchem-2350	220	52	novel	novel	ADJ
eurjchem-2350	220	53	coronavirus	coronavirus	NOUN
eurjchem-2350	220	54	(	(	PUNCT
eurjchem-2350	220	55	2019	2019	NUM
eurjchem-2350	220	56	-	-	PUNCT
eurjchem-2350	220	57	ncov	ncov	NOUN
eurjchem-2350	220	58	)	)	PUNCT
eurjchem-2350	220	59	in	in	ADP
eurjchem-2350	220	60	vitro	vitro	X
eurjchem-2350	220	61	.	.	PUNCT
eurjchem-2350	221	1	cell	cell	NOUN
eurjchem-2350	221	2	res	re	NOUN
eurjchem-2350	221	3	.	.	PUNCT
eurjchem-2350	222	1	2020	2020	NUM
eurjchem-2350	222	2	,	,	PUNCT
eurjchem-2350	222	3	30	30	NUM
eurjchem-2350	222	4	(	(	PUNCT
eurjchem-2350	222	5	3	3	NUM
eurjchem-2350	222	6	)	)	PUNCT
eurjchem-2350	222	7	,	,	PUNCT
eurjchem-2350	222	8	269–271	269–271	NUM
eurjchem-2350	222	9	.	.	PUNCT
eurjchem-2350	223	1	[	[	X
eurjchem-2350	223	2	6	6	NUM
eurjchem-2350	223	3	]	]	PUNCT
eurjchem-2350	223	4	.	.	PUNCT
eurjchem-2350	224	1	gao	gao	PROPN
eurjchem-2350	224	2	,	,	PUNCT
eurjchem-2350	224	3	j.	j.	PROPN
eurjchem-2350	224	4	;	;	PUNCT
eurjchem-2350	224	5	tian	tian	PROPN
eurjchem-2350	224	6	,	,	PUNCT
eurjchem-2350	224	7	z.	z.	PROPN
eurjchem-2350	224	8	;	;	PUNCT
eurjchem-2350	224	9	yang	yang	PROPN
eurjchem-2350	224	10	,	,	PUNCT
eurjchem-2350	224	11	x.	x.	PROPN
eurjchem-2350	224	12	breakthrough	breakthrough	PROPN
eurjchem-2350	224	13	:	:	PUNCT
eurjchem-2350	224	14	chloroquine	chloroquine	NOUN
eurjchem-2350	224	15	phosphate	phosphate	NOUN
eurjchem-2350	224	16	has	have	AUX
eurjchem-2350	224	17	shown	show	VERB
eurjchem-2350	224	18	apparent	apparent	ADJ
eurjchem-2350	224	19	efficacy	efficacy	NOUN
eurjchem-2350	224	20	in	in	ADP
eurjchem-2350	224	21	treatment	treatment	NOUN
eurjchem-2350	224	22	of	of	ADP
eurjchem-2350	224	23	covid-19	covid-19	PROPN
eurjchem-2350	224	24	associated	associated	ADJ
eurjchem-2350	224	25	pneumonia	pneumonia	NOUN
eurjchem-2350	224	26	in	in	ADP
eurjchem-2350	224	27	clinical	clinical	ADJ
eurjchem-2350	224	28	studies	study	NOUN
eurjchem-2350	224	29	.	.	PUNCT
eurjchem-2350	225	1	biosci	biosci	PROPN
eurjchem-2350	225	2	.	.	PUNCT
eurjchem-2350	226	1	trends	trend	NOUN
eurjchem-2350	226	2	2020	2020	NUM
eurjchem-2350	226	3	,	,	PUNCT
eurjchem-2350	226	4	14	14	NUM
eurjchem-2350	226	5	(	(	PUNCT
eurjchem-2350	226	6	1	1	NUM
eurjchem-2350	226	7	)	)	PUNCT
eurjchem-2350	226	8	,	,	PUNCT
eurjchem-2350	226	9	72–73	72–73	ADJ
eurjchem-2350	226	10	.	.	PUNCT
eurjchem-2350	227	1	[	[	X
eurjchem-2350	227	2	7	7	NUM
eurjchem-2350	227	3	]	]	PUNCT
eurjchem-2350	227	4	.	.	PUNCT
eurjchem-2350	228	1	li	li	PROPN
eurjchem-2350	228	2	,	,	PUNCT
eurjchem-2350	228	3	g.	g.	PROPN
eurjchem-2350	228	4	;	;	PUNCT
eurjchem-2350	228	5	de	de	X
eurjchem-2350	228	6	clercq	clercq	PROPN
eurjchem-2350	228	7	,	,	PUNCT
eurjchem-2350	228	8	e.	e.	PROPN
eurjchem-2350	228	9	therapeutic	therapeutic	ADJ
eurjchem-2350	228	10	options	option	NOUN
eurjchem-2350	228	11	for	for	ADP
eurjchem-2350	228	12	the	the	DET
eurjchem-2350	228	13	2019	2019	NUM
eurjchem-2350	228	14	novel	novel	ADJ
eurjchem-2350	228	15	coronavirus	coronavirus	NOUN
eurjchem-2350	228	16	(	(	PUNCT
eurjchem-2350	228	17	2019	2019	NUM
eurjchem-2350	228	18	-	-	PUNCT
eurjchem-2350	228	19	ncov	ncov	NOUN
eurjchem-2350	228	20	)	)	PUNCT
eurjchem-2350	228	21	.	.	PUNCT
eurjchem-2350	229	1	nat	nat	PROPN
eurjchem-2350	229	2	.	.	PUNCT
eurjchem-2350	230	1	rev	rev	PROPN
eurjchem-2350	230	2	.	.	PROPN
eurjchem-2350	230	3	drug	drug	NOUN
eurjchem-2350	230	4	discov	discov	NOUN
eurjchem-2350	230	5	.	.	PUNCT
eurjchem-2350	231	1	2020	2020	NUM
eurjchem-2350	231	2	,	,	PUNCT
eurjchem-2350	231	3	19	19	NUM
eurjchem-2350	231	4	(	(	PUNCT
eurjchem-2350	231	5	3	3	NUM
eurjchem-2350	231	6	)	)	PUNCT
eurjchem-2350	231	7	,	,	PUNCT
eurjchem-2350	231	8	149	149	NUM
eurjchem-2350	231	9	–	–	SYM
eurjchem-2350	231	10	150	150	NUM
eurjchem-2350	231	11	.	.	PUNCT
eurjchem-2350	232	1	[	[	X
eurjchem-2350	232	2	8	8	NUM
eurjchem-2350	232	3	]	]	PUNCT
eurjchem-2350	232	4	.	.	PUNCT
eurjchem-2350	232	5	vijayalakshmi	vijayalakshmi	NOUN
eurjchem-2350	232	6	,	,	PUNCT
eurjchem-2350	232	7	p.	p.	NOUN
eurjchem-2350	232	8	;	;	PUNCT
eurjchem-2350	232	9	daisy	daisy	NOUN
eurjchem-2350	232	10	,	,	PUNCT
eurjchem-2350	232	11	p.	p.	NOUN
eurjchem-2350	232	12	effective	effective	ADJ
eurjchem-2350	232	13	interaction	interaction	NOUN
eurjchem-2350	232	14	studies	study	NOUN
eurjchem-2350	232	15	for	for	ADP
eurjchem-2350	232	16	inhibition	inhibition	NOUN
eurjchem-2350	232	17	of	of	ADP
eurjchem-2350	232	18	dna	dna	NOUN
eurjchem-2350	232	19	ligase	ligase	ADJ
eurjchem-2350	232	20	protein	protein	NOUN
eurjchem-2350	232	21	from	from	ADP
eurjchem-2350	232	22	staphylococcus	staphylococcus	NOUN
eurjchem-2350	232	23	aureus	aureus	NOUN
eurjchem-2350	232	24	.	.	PUNCT
eurjchem-2350	233	1	j.	j.	PROPN
eurjchem-2350	233	2	recept	recept	PROPN
eurjchem-2350	233	3	.	.	PUNCT
eurjchem-2350	233	4	signal	signal	PROPN
eurjchem-2350	233	5	transduct	transduct	PROPN
eurjchem-2350	233	6	.	.	PUNCT
eurjchem-2350	234	1	res	re	NOUN
eurjchem-2350	234	2	.	.	PROPN
eurjchem-2350	234	3	2015	2015	NUM
eurjchem-2350	234	4	,	,	PUNCT
eurjchem-2350	234	5	35	35	NUM
eurjchem-2350	234	6	(	(	PUNCT
eurjchem-2350	234	7	1	1	NUM
eurjchem-2350	234	8	)	)	PUNCT
eurjchem-2350	234	9	,	,	PUNCT
eurjchem-2350	234	10	15–25	15–25	NUM
eurjchem-2350	234	11	.	.	PUNCT
eurjchem-2350	235	1	[	[	X
eurjchem-2350	235	2	9	9	NUM
eurjchem-2350	235	3	]	]	PUNCT
eurjchem-2350	235	4	.	.	PUNCT
eurjchem-2350	235	5	choy	choy	NOUN
eurjchem-2350	235	6	,	,	PUNCT
eurjchem-2350	235	7	k.-t	k.-t	PROPN
eurjchem-2350	235	8	.	.	PUNCT
eurjchem-2350	235	9	;	;	PUNCT
eurjchem-2350	235	10	wong	wong	PROPN
eurjchem-2350	235	11	,	,	PUNCT
eurjchem-2350	235	12	a.	a.	NOUN
eurjchem-2350	235	13	y.-l	y.-l	PROPN
eurjchem-2350	235	14	.	.	PUNCT
eurjchem-2350	236	1	;	;	PUNCT
eurjchem-2350	236	2	kaewpreedee	kaewpreedee	PROPN
eurjchem-2350	236	3	,	,	PUNCT
eurjchem-2350	236	4	p.	p.	PROPN
eurjchem-2350	236	5	;	;	PUNCT
eurjchem-2350	236	6	sia	sia	PROPN
eurjchem-2350	236	7	,	,	PUNCT
eurjchem-2350	236	8	s.	s.	PROPN
eurjchem-2350	236	9	f.	f.	PROPN
eurjchem-2350	236	10	;	;	PUNCT
eurjchem-2350	236	11	chen	chen	PROPN
eurjchem-2350	236	12	,	,	PUNCT
eurjchem-2350	236	13	d.	d.	PROPN
eurjchem-2350	236	14	;	;	PUNCT
eurjchem-2350	236	15	hui	hui	PROPN
eurjchem-2350	236	16	,	,	PUNCT
eurjchem-2350	236	17	k.	k.	PROPN
eurjchem-2350	237	1	p.	p.	PROPN
eurjchem-2350	237	2	y.	y.	PROPN
eurjchem-2350	237	3	;	;	PUNCT
eurjchem-2350	237	4	chu	chu	PROPN
eurjchem-2350	237	5	,	,	PUNCT
eurjchem-2350	237	6	d.	d.	PROPN
eurjchem-2350	237	7	k.	k.	PROPN
eurjchem-2350	237	8	w.	w.	PROPN
eurjchem-2350	237	9	;	;	PUNCT
eurjchem-2350	237	10	chan	chan	PROPN
eurjchem-2350	237	11	,	,	PUNCT
eurjchem-2350	237	12	m.	m.	PROPN
eurjchem-2350	237	13	c.	c.	PROPN
eurjchem-2350	237	14	w.	w.	PROPN
eurjchem-2350	237	15	;	;	PUNCT
eurjchem-2350	237	16	cheung	cheung	PROPN
eurjchem-2350	237	17	,	,	PUNCT
eurjchem-2350	237	18	p.	p.	NOUN
eurjchem-2350	237	19	p.-h	p.-h	PROPN
eurjchem-2350	237	20	.	.	PUNCT
eurjchem-2350	237	21	;	;	PUNCT
eurjchem-2350	237	22	huang	huang	PROPN
eurjchem-2350	237	23	,	,	PUNCT
eurjchem-2350	237	24	x.	x.	PROPN
eurjchem-2350	237	25	;	;	PUNCT
eurjchem-2350	237	26	peiris	peiris	NOUN
eurjchem-2350	237	27	,	,	PUNCT
eurjchem-2350	237	28	m.	m.	NOUN
eurjchem-2350	237	29	;	;	PUNCT
eurjchem-2350	237	30	yen	yen	NOUN
eurjchem-2350	237	31	,	,	PUNCT
eurjchem-2350	237	32	h.-l	h.-l	PROPN
eurjchem-2350	237	33	.	.	PUNCT
eurjchem-2350	238	1	remdesivir	remdesivir	PROPN
eurjchem-2350	238	2	,	,	PUNCT
eurjchem-2350	238	3	lopinavir	lopinavir	PROPN
eurjchem-2350	238	4	,	,	PUNCT
eurjchem-2350	238	5	emetine	emetine	ADJ
eurjchem-2350	238	6	,	,	PUNCT
eurjchem-2350	238	7	and	and	CCONJ
eurjchem-2350	238	8	homoharring	homoharring	NOUN
eurjchem-2350	238	9	tonine	tonine	PROPN
eurjchem-2350	238	10	inhibit	inhibit	VERB
eurjchem-2350	238	11	sars	sar	NOUN
eurjchem-2350	238	12	-	-	PUNCT
eurjchem-2350	238	13	cov-2	cov-2	NOUN
eurjchem-2350	238	14	replication	replication	NOUN
eurjchem-2350	238	15	in	in	ADP
eurjchem-2350	238	16	vitro	vitro	X
eurjchem-2350	238	17	.	.	PUNCT
eurjchem-2350	239	1	antiviral	antiviral	ADJ
eurjchem-2350	239	2	res	re	NOUN
eurjchem-2350	239	3	.	.	PUNCT
eurjchem-2350	240	1	2020	2020	NUM
eurjchem-2350	240	2	,	,	PUNCT
eurjchem-2350	240	3	178	178	NUM
eurjchem-2350	240	4	(	(	PUNCT
eurjchem-2350	240	5	104786	104786	NUM
eurjchem-2350	240	6	)	)	PUNCT
eurjchem-2350	240	7	,	,	PUNCT
eurjchem-2350	240	8	104786	104786	NUM
eurjchem-2350	240	9	.	.	PUNCT
eurjchem-2350	241	1	mailto:praveenbiochemku@gmail.com	mailto:praveenbiochemku@gmail.com	X
eurjchem-2350	242	1	https://orcid.org/0000-0002-8034-6348	https://orcid.org/0000-0002-8034-6348	PROPN
eurjchem-2350	243	1	mailto:santhosh.1507@rediffmail.com	mailto:santhosh.1507@rediffmail.com	PROPN
eurjchem-2350	243	2	https://orcid.org/0000-0001-8734-2991	https://orcid.org/0000-0001-8734-2991	PROPN
eurjchem-2350	243	3	mailto:sakthivelbala.s@gmail.com	mailto:sakthivelbala.s@gmail.com	PROPN
eurjchem-2350	244	1	https://orcid.org/0000-0003-1066-9878	https://orcid.org/0000-0003-1066-9878	PROPN
eurjchem-2350	244	2	mailto:satya1782005@gmail.com	mailto:satya1782005@gmail.com	PROPN
eurjchem-2350	244	3	https://orcid.org/0000-0003-4511-3749	https://orcid.org/0000-0003-4511-3749	VERB
eurjchem-2350	244	4	mailto:rajachur@gmail.com	mailto:rajachur@gmail.com	PROPN
eurjchem-2350	244	5	mailto:anr@kuvempu.ac.in	mailto:anr@kuvempu.ac.in	NOUN
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eurjchem-2350	244	18	(	(	PUNCT
eurjchem-2350	244	19	1	1	NUM
eurjchem-2350	244	20	)	)	PUNCT
eurjchem-2350	244	21	(	(	PUNCT
eurjchem-2350	244	22	2023	2023	NUM
eurjchem-2350	244	23	)	)	PUNCT
eurjchem-2350	244	24	30	30	NUM
eurjchem-2350	244	25	-	-	SYM
eurjchem-2350	244	26	38	38	NUM
eurjchem-2350	244	27	37	37	NUM
eurjchem-2350	244	28	2023	2023	NUM
eurjchem-2350	244	29	–	–	PUNCT
eurjchem-2350	244	30	european	european	ADJ
eurjchem-2350	244	31	journal	journal	NOUN
eurjchem-2350	244	32	of	of	ADP
eurjchem-2350	244	33	chemistry	chemistry	NOUN
eurjchem-2350	244	34	–	–	PUNCT
eurjchem-2350	244	35	cc	cc	NOUN
eurjchem-2350	244	36	by	by	ADP
eurjchem-2350	244	37	nc	nc	PROPN
eurjchem-2350	244	38	–	–	PUNCT
eurjchem-2350	244	39	doi	doi	PROPN
eurjchem-2350	244	40	:	:	PUNCT
eurjchem-2350	244	41	10.5155	10.5155	NUM
eurjchem-2350	244	42	/	/	SYM
eurjchem-2350	244	43	eurjchem.14.1.30	eurjchem.14.1.30	PROPN
eurjchem-2350	244	44	-	-	PUNCT
eurjchem-2350	244	45	38.2350	38.2350	NUM
eurjchem-2350	245	1	[	[	X
eurjchem-2350	245	2	10	10	NUM
eurjchem-2350	245	3	]	]	PUNCT
eurjchem-2350	245	4	.	.	PUNCT
eurjchem-2350	246	1	zhu	zhu	PROPN
eurjchem-2350	246	2	,	,	PUNCT
eurjchem-2350	246	3	n.	n.	PROPN
eurjchem-2350	246	4	;	;	PUNCT
eurjchem-2350	246	5	zhang	zhang	PROPN
eurjchem-2350	246	6	,	,	PUNCT
eurjchem-2350	246	7	d.	d.	PROPN
eurjchem-2350	246	8	;	;	PUNCT
eurjchem-2350	246	9	wang	wang	PROPN
eurjchem-2350	246	10	,	,	PUNCT
eurjchem-2350	246	11	w.	w.	PROPN
eurjchem-2350	246	12	;	;	PUNCT
eurjchem-2350	246	13	li	li	PROPN
eurjchem-2350	246	14	,	,	PUNCT
eurjchem-2350	246	15	x.	x.	PROPN
eurjchem-2350	246	16	;	;	PUNCT
eurjchem-2350	246	17	yang	yang	PROPN
eurjchem-2350	246	18	,	,	PUNCT
eurjchem-2350	246	19	b.	b.	PROPN
eurjchem-2350	246	20	;	;	PUNCT
eurjchem-2350	246	21	song	song	PROPN
eurjchem-2350	246	22	,	,	PUNCT
eurjchem-2350	246	23	j.	j.	PROPN
eurjchem-2350	246	24	;	;	PUNCT
eurjchem-2350	246	25	zhao	zhao	PROPN
eurjchem-2350	246	26	,	,	PUNCT
eurjchem-2350	246	27	x.	x.	PROPN
eurjchem-2350	246	28	;	;	PUNCT
eurjchem-2350	246	29	huang	huang	PROPN
eurjchem-2350	246	30	,	,	PUNCT
eurjchem-2350	246	31	b.	b.	PROPN
eurjchem-2350	246	32	;	;	PUNCT
eurjchem-2350	246	33	shi	shi	PROPN
eurjchem-2350	246	34	,	,	PUNCT
eurjchem-2350	246	35	w.	w.	PROPN
eurjchem-2350	246	36	;	;	PUNCT
eurjchem-2350	246	37	lu	lu	PROPN
eurjchem-2350	246	38	,	,	PUNCT
eurjchem-2350	246	39	r.	r.	PROPN
eurjchem-2350	246	40	;	;	PUNCT
eurjchem-2350	246	41	niu	niu	PROPN
eurjchem-2350	246	42	,	,	PUNCT
eurjchem-2350	246	43	p.	p.	NOUN
eurjchem-2350	246	44	;	;	PUNCT
eurjchem-2350	246	45	zhan	zhan	PROPN
eurjchem-2350	246	46	,	,	PUNCT
eurjchem-2350	246	47	f.	f.	PROPN
eurjchem-2350	246	48	;	;	PUNCT
eurjchem-2350	246	49	ma	ma	PROPN
eurjchem-2350	246	50	,	,	PUNCT
eurjchem-2350	246	51	x.	x.	PROPN
eurjchem-2350	246	52	;	;	PUNCT
eurjchem-2350	246	53	wang	wang	PROPN
eurjchem-2350	246	54	,	,	PUNCT
eurjchem-2350	246	55	d.	d.	PROPN
eurjchem-2350	246	56	;	;	PUNCT
eurjchem-2350	246	57	xu	xu	PROPN
eurjchem-2350	246	58	,	,	PUNCT
eurjchem-2350	246	59	w.	w.	PROPN
eurjchem-2350	246	60	;	;	PUNCT
eurjchem-2350	246	61	wu	wu	PROPN
eurjchem-2350	246	62	,	,	PUNCT
eurjchem-2350	246	63	g.	g.	PROPN
eurjchem-2350	246	64	;	;	PUNCT
eurjchem-2350	246	65	gao	gao	PROPN
eurjchem-2350	246	66	,	,	PUNCT
eurjchem-2350	246	67	g.	g.	PROPN
eurjchem-2350	246	68	f.	f.	PROPN
eurjchem-2350	246	69	;	;	PUNCT
eurjchem-2350	246	70	tan	tan	PROPN
eurjchem-2350	246	71	,	,	PUNCT
eurjchem-2350	246	72	w.	w.	PROPN
eurjchem-2350	246	73	;	;	PUNCT
eurjchem-2350	246	74	china	china	PROPN
eurjchem-2350	246	75	novel	novel	PROPN
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eurjchem-2350	246	77	investigating	investigate	VERB
eurjchem-2350	246	78	and	and	CCONJ
eurjchem-2350	246	79	research	research	NOUN
eurjchem-2350	246	80	team	team	NOUN
eurjchem-2350	246	81	.	.	PUNCT
eurjchem-2350	247	1	a	a	DET
eurjchem-2350	247	2	novel	novel	ADJ
eurjchem-2350	247	3	coronavirus	coronavirus	NOUN
eurjchem-2350	247	4	from	from	ADP
eurjchem-2350	247	5	patients	patient	NOUN
eurjchem-2350	247	6	with	with	ADP
eurjchem-2350	247	7	pneumonia	pneumonia	NOUN
eurjchem-2350	247	8	in	in	ADP
eurjchem-2350	247	9	china	china	PROPN
eurjchem-2350	247	10	,	,	PUNCT
eurjchem-2350	247	11	2019	2019	NUM
eurjchem-2350	247	12	.	.	PUNCT
eurjchem-2350	248	1	n.	n.	PROPN
eurjchem-2350	248	2	engl	engl	PROPN
eurjchem-2350	248	3	.	.	PUNCT
eurjchem-2350	249	1	j.	j.	PROPN
eurjchem-2350	249	2	med	med	PROPN
eurjchem-2350	249	3	.	.	PUNCT
eurjchem-2350	250	1	2020	2020	NUM
eurjchem-2350	250	2	,	,	PUNCT
eurjchem-2350	250	3	382	382	NUM
eurjchem-2350	250	4	(	(	PUNCT
eurjchem-2350	250	5	8)	8)	NUM
eurjchem-2350	250	6	,	,	PUNCT
eurjchem-2350	250	7	727–733	727–733	NUM
eurjchem-2350	250	8	.	.	PUNCT
eurjchem-2350	251	1	[	[	X
eurjchem-2350	251	2	11	11	NUM
eurjchem-2350	251	3	]	]	PUNCT
eurjchem-2350	251	4	.	.	PUNCT
eurjchem-2350	251	5	kwiek	kwiek	PROPN
eurjchem-2350	251	6	,	,	PUNCT
eurjchem-2350	251	7	j.	j.	PROPN
eurjchem-2350	251	8	j.	j.	PROPN
eurjchem-2350	251	9	;	;	PUNCT
eurjchem-2350	251	10	haystead	haystead	ADJ
eurjchem-2350	251	11	,	,	PUNCT
eurjchem-2350	251	12	t.	t.	PROPN
eurjchem-2350	251	13	a.	a.	PROPN
eurjchem-2350	251	14	j.	j.	PROPN
eurjchem-2350	251	15	;	;	PUNCT
eurjchem-2350	252	1	rudolph	rudolph	PROPN
eurjchem-2350	252	2	,	,	PUNCT
eurjchem-2350	252	3	j.	j.	PROPN
eurjchem-2350	252	4	kinetic	kinetic	ADJ
eurjchem-2350	252	5	mechanism	mechanism	NOUN
eurjchem-2350	252	6	of	of	ADP
eurjchem-2350	252	7	quinone	quinone	NOUN
eurjchem-2350	252	8	oxidoreductase	oxidoreductase	NOUN
eurjchem-2350	252	9	2	2	NUM
eurjchem-2350	252	10	and	and	CCONJ
eurjchem-2350	252	11	its	its	PRON
eurjchem-2350	252	12	inhibition	inhibition	NOUN
eurjchem-2350	252	13	by	by	ADP
eurjchem-2350	252	14	the	the	DET
eurjchem-2350	252	15	antimalarial	antimalarial	ADJ
eurjchem-2350	252	16	quinolines	quinoline	NOUN
eurjchem-2350	252	17	.	.	PUNCT
eurjchem-2350	253	1	biochemistry	biochemistry	NOUN
eurjchem-2350	253	2	2004	2004	NUM
eurjchem-2350	253	3	,	,	PUNCT
eurjchem-2350	253	4	43	43	NUM
eurjchem-2350	253	5	(	(	PUNCT
eurjchem-2350	253	6	15	15	NUM
eurjchem-2350	253	7	)	)	PUNCT
eurjchem-2350	253	8	,	,	PUNCT
eurjchem-2350	253	9	4538–4547	4538–4547	NUM
eurjchem-2350	253	10	.	.	PUNCT
eurjchem-2350	254	1	[	[	X
eurjchem-2350	254	2	12	12	NUM
eurjchem-2350	254	3	]	]	PUNCT
eurjchem-2350	254	4	.	.	PUNCT
eurjchem-2350	255	1	devaux	devaux	PROPN
eurjchem-2350	255	2	,	,	PUNCT
eurjchem-2350	255	3	c.	c.	PROPN
eurjchem-2350	255	4	a.	a.	PROPN
eurjchem-2350	255	5	;	;	PUNCT
eurjchem-2350	255	6	rolain	rolain	PROPN
eurjchem-2350	255	7	,	,	PUNCT
eurjchem-2350	255	8	j.-m	j.-m	NOUN
eurjchem-2350	255	9	.	.	PUNCT
eurjchem-2350	255	10	;	;	PUNCT
eurjchem-2350	256	1	colson	colson	PROPN
eurjchem-2350	256	2	,	,	PUNCT
eurjchem-2350	256	3	p.	p.	NOUN
eurjchem-2350	256	4	;	;	PUNCT
eurjchem-2350	256	5	raoult	raoult	VERB
eurjchem-2350	256	6	,	,	PUNCT
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eurjchem-2350	256	9	insights	insight	NOUN
eurjchem-2350	256	10	on	on	ADP
eurjchem-2350	256	11	the	the	DET
eurjchem-2350	256	12	antiviral	antiviral	ADJ
eurjchem-2350	256	13	effects	effect	NOUN
eurjchem-2350	256	14	of	of	ADP
eurjchem-2350	256	15	chloroquine	chloroquine	NOUN
eurjchem-2350	256	16	against	against	ADP
eurjchem-2350	256	17	coronavirus	coronavirus	NOUN
eurjchem-2350	256	18	:	:	PUNCT
eurjchem-2350	256	19	what	what	PRON
eurjchem-2350	256	20	to	to	PART
eurjchem-2350	256	21	expect	expect	VERB
eurjchem-2350	256	22	for	for	ADP
eurjchem-2350	256	23	covid-19	covid-19	PROPN
eurjchem-2350	256	24	?	?	PUNCT
eurjchem-2350	256	25	int	int	NOUN
eurjchem-2350	256	26	.	.	PUNCT
eurjchem-2350	257	1	j.	j.	PROPN
eurjchem-2350	257	2	antimicrob	antimicrob	PROPN
eurjchem-2350	257	3	.	.	PUNCT
eurjchem-2350	258	1	agents	agent	NOUN
eurjchem-2350	258	2	2020	2020	NUM
eurjchem-2350	258	3	,	,	PUNCT
eurjchem-2350	258	4	55	55	NUM
eurjchem-2350	258	5	(	(	PUNCT
eurjchem-2350	258	6	5	5	NUM
eurjchem-2350	258	7	)	)	PUNCT
eurjchem-2350	258	8	,	,	PUNCT
eurjchem-2350	258	9	105938	105938	NUM
eurjchem-2350	258	10	.	.	PUNCT
eurjchem-2350	259	1	[	[	X
eurjchem-2350	259	2	13	13	NUM
eurjchem-2350	259	3	]	]	PUNCT
eurjchem-2350	259	4	.	.	PUNCT
eurjchem-2350	259	5	tsiang	tsiang	PROPN
eurjchem-2350	259	6	,	,	PUNCT
eurjchem-2350	259	7	h.	h.	PROPN
eurjchem-2350	259	8	;	;	PUNCT
eurjchem-2350	259	9	superti	superti	PROPN
eurjchem-2350	259	10	,	,	PUNCT
eurjchem-2350	259	11	f.	f.	PROPN
eurjchem-2350	259	12	ammonium	ammonium	NOUN
eurjchem-2350	259	13	chloride	chloride	NOUN
eurjchem-2350	259	14	and	and	CCONJ
eurjchem-2350	259	15	chloroquine	chloroquine	NOUN
eurjchem-2350	259	16	inhibit	inhibit	NOUN
eurjchem-2350	259	17	rabies	rabie	NOUN
eurjchem-2350	259	18	virus	virus	NOUN
eurjchem-2350	259	19	infection	infection	NOUN
eurjchem-2350	259	20	in	in	ADP
eurjchem-2350	259	21	neuroblastoma	neuroblastoma	ADJ
eurjchem-2350	259	22	cells	cell	NOUN
eurjchem-2350	259	23	.	.	PUNCT
eurjchem-2350	260	1	arch	arch	NOUN
eurjchem-2350	260	2	.	.	PUNCT
eurjchem-2350	261	1	virol	virol	NOUN
eurjchem-2350	261	2	.	.	PUNCT
eurjchem-2350	262	1	1984	1984	NUM
eurjchem-2350	262	2	,	,	PUNCT
eurjchem-2350	262	3	81	81	NUM
eurjchem-2350	262	4	(	(	PUNCT
eurjchem-2350	262	5	3–4	3–4	NUM
eurjchem-2350	262	6	)	)	PUNCT
eurjchem-2350	262	7	,	,	PUNCT
eurjchem-2350	263	1	377–382	377–382	NUM
eurjchem-2350	263	2	.	.	PUNCT
eurjchem-2350	264	1	[	[	X
eurjchem-2350	264	2	14	14	NUM
eurjchem-2350	264	3	]	]	PUNCT
eurjchem-2350	264	4	.	.	PUNCT
eurjchem-2350	265	1	kronenberger	kronenberger	NOUN
eurjchem-2350	265	2	,	,	PUNCT
eurjchem-2350	265	3	p.	p.	NOUN
eurjchem-2350	265	4	;	;	PUNCT
eurjchem-2350	265	5	vrijsen	vrijsen	PROPN
eurjchem-2350	265	6	,	,	PUNCT
eurjchem-2350	265	7	r.	r.	PROPN
eurjchem-2350	265	8	;	;	PUNCT
eurjchem-2350	265	9	boeyé	boeyé	NOUN
eurjchem-2350	265	10	,	,	PUNCT
eurjchem-2350	265	11	a.	a.	NOUN
eurjchem-2350	265	12	chloroquine	chloroquine	NOUN
eurjchem-2350	265	13	induces	induce	VERB
eurjchem-2350	265	14	empty	empty	ADJ
eurjchem-2350	265	15	capsid	capsid	ADJ
eurjchem-2350	265	16	formation	formation	NOUN
eurjchem-2350	265	17	during	during	ADP
eurjchem-2350	265	18	poliovirus	poliovirus	NOUN
eurjchem-2350	265	19	eclipse	eclipse	NOUN
eurjchem-2350	265	20	.	.	PUNCT
eurjchem-2350	266	1	j.	j.	PROPN
eurjchem-2350	266	2	virol	virol	PROPN
eurjchem-2350	266	3	.	.	PUNCT
eurjchem-2350	267	1	1991	1991	NUM
eurjchem-2350	267	2	,	,	PUNCT
eurjchem-2350	267	3	65	65	NUM
eurjchem-2350	267	4	(	(	PUNCT
eurjchem-2350	267	5	12	12	NUM
eurjchem-2350	267	6	)	)	PUNCT
eurjchem-2350	267	7	,	,	PUNCT
eurjchem-2350	267	8	7008–7011	7008–7011	NUM
eurjchem-2350	267	9	.	.	PUNCT
eurjchem-2350	268	1	[	[	X
eurjchem-2350	268	2	15	15	NUM
eurjchem-2350	268	3	]	]	SYM
eurjchem-2350	268	4	.	.	PUNCT
eurjchem-2350	269	1	savarino	savarino	PROPN
eurjchem-2350	269	2	,	,	PUNCT
eurjchem-2350	269	3	a.	a.	NOUN
eurjchem-2350	269	4	;	;	PUNCT
eurjchem-2350	269	5	gennero	gennero	PROPN
eurjchem-2350	269	6	,	,	PUNCT
eurjchem-2350	269	7	l.	l.	PROPN
eurjchem-2350	269	8	;	;	PUNCT
eurjchem-2350	269	9	sperber	sperber	PROPN
eurjchem-2350	269	10	,	,	PUNCT
eurjchem-2350	269	11	k.	k.	PROPN
eurjchem-2350	269	12	;	;	PUNCT
eurjchem-2350	269	13	boelaert	boelaert	PROPN
eurjchem-2350	269	14	,	,	PUNCT
eurjchem-2350	269	15	j.	j.	PROPN
eurjchem-2350	269	16	r.	r.	PROPN
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eurjchem-2350	269	18	anti	anti	ADJ
eurjchem-2350	269	19	-	-	ADJ
eurjchem-2350	269	20	hiv-1	hiv-1	ADJ
eurjchem-2350	269	21	activity	activity	NOUN
eurjchem-2350	269	22	of	of	ADP
eurjchem-2350	269	23	chloroquine	chloroquine	NOUN
eurjchem-2350	269	24	.	.	PUNCT
eurjchem-2350	270	1	j.	j.	PROPN
eurjchem-2350	270	2	clin	clin	PROPN
eurjchem-2350	270	3	.	.	PUNCT
eurjchem-2350	271	1	virol	virol	PROPN
eurjchem-2350	271	2	.	.	PUNCT
eurjchem-2350	272	1	2001	2001	NUM
eurjchem-2350	272	2	,	,	PUNCT
eurjchem-2350	272	3	20	20	NUM
eurjchem-2350	272	4	(	(	PUNCT
eurjchem-2350	272	5	3	3	NUM
eurjchem-2350	272	6	)	)	PUNCT
eurjchem-2350	272	7	,	,	PUNCT
eurjchem-2350	272	8	131–135	131–135	NUM
eurjchem-2350	272	9	.	.	PUNCT
eurjchem-2350	273	1	[	[	X
eurjchem-2350	273	2	16	16	NUM
eurjchem-2350	273	3	]	]	PUNCT
eurjchem-2350	273	4	.	.	PUNCT
eurjchem-2350	273	5	bishop	bishop	PROPN
eurjchem-2350	273	6	,	,	PUNCT
eurjchem-2350	273	7	n.	n.	PROPN
eurjchem-2350	273	8	e.	e.	PROPN
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eurjchem-2350	273	10	of	of	ADP
eurjchem-2350	273	11	potential	potential	ADJ
eurjchem-2350	273	12	inhibitors	inhibitor	NOUN
eurjchem-2350	273	13	of	of	ADP
eurjchem-2350	273	14	hepatitis	hepatitis	PROPN
eurjchem-2350	273	15	a	a	DET
eurjchem-2350	273	16	virus	virus	NOUN
eurjchem-2350	273	17	uncoating	uncoate	VERB
eurjchem-2350	273	18	.	.	PUNCT
eurjchem-2350	274	1	intervirology	intervirology	NOUN
eurjchem-2350	274	2	1998	1998	NUM
eurjchem-2350	274	3	,	,	PUNCT
eurjchem-2350	274	4	41	41	NUM
eurjchem-2350	274	5	(	(	PUNCT
eurjchem-2350	274	6	6	6	NUM
eurjchem-2350	274	7	)	)	PUNCT
eurjchem-2350	274	8	,	,	PUNCT
eurjchem-2350	274	9	261–271	261–271	NUM
eurjchem-2350	274	10	.	.	PUNCT
eurjchem-2350	275	1	[	[	X
eurjchem-2350	275	2	17	17	NUM
eurjchem-2350	275	3	]	]	PUNCT
eurjchem-2350	275	4	.	.	PUNCT
eurjchem-2350	276	1	delvecchio	delvecchio	PROPN
eurjchem-2350	276	2	,	,	PUNCT
eurjchem-2350	276	3	r.	r.	PROPN
eurjchem-2350	276	4	;	;	PUNCT
eurjchem-2350	276	5	higa	higa	PROPN
eurjchem-2350	276	6	,	,	PUNCT
eurjchem-2350	276	7	l.	l.	PROPN
eurjchem-2350	276	8	m.	m.	PROPN
eurjchem-2350	276	9	;	;	PUNCT
eurjchem-2350	276	10	pezzuto	pezzuto	PROPN
eurjchem-2350	276	11	,	,	PUNCT
eurjchem-2350	276	12	p.	p.	PROPN
eurjchem-2350	276	13	;	;	PUNCT
eurjchem-2350	276	14	valadão	valadão	PROPN
eurjchem-2350	276	15	,	,	PUNCT
eurjchem-2350	276	16	a.	a.	PROPN
eurjchem-2350	276	17	l.	l.	PROPN
eurjchem-2350	276	18	;	;	PUNCT
eurjchem-2350	276	19	garcez	garcez	NOUN
eurjchem-2350	276	20	,	,	PUNCT
eurjchem-2350	276	21	p.	p.	PROPN
eurjchem-2350	276	22	p.	p.	PROPN
eurjchem-2350	276	23	;	;	PUNCT
eurjchem-2350	276	24	monteiro	monteiro	PROPN
eurjchem-2350	276	25	,	,	PUNCT
eurjchem-2350	276	26	f.	f.	PROPN
eurjchem-2350	276	27	l.	l.	PROPN
eurjchem-2350	276	28	;	;	PUNCT
eurjchem-2350	276	29	loiola	loiola	PROPN
eurjchem-2350	276	30	,	,	PUNCT
eurjchem-2350	276	31	e.	e.	PROPN
eurjchem-2350	276	32	c.	c.	PROPN
eurjchem-2350	276	33	;	;	PUNCT
eurjchem-2350	276	34	dias	dias	PROPN
eurjchem-2350	276	35	,	,	PUNCT
eurjchem-2350	276	36	a.	a.	NOUN
eurjchem-2350	276	37	a.	a.	NOUN
eurjchem-2350	276	38	;	;	PUNCT
eurjchem-2350	276	39	silva	silva	PROPN
eurjchem-2350	276	40	,	,	PUNCT
eurjchem-2350	276	41	f.	f.	PROPN
eurjchem-2350	276	42	j.	j.	PROPN
eurjchem-2350	276	43	m.	m.	PROPN
eurjchem-2350	276	44	;	;	PUNCT
eurjchem-2350	276	45	aliota	aliota	NOUN
eurjchem-2350	276	46	,	,	PUNCT
eurjchem-2350	276	47	m.	m.	NOUN
eurjchem-2350	276	48	t.	t.	PROPN
eurjchem-2350	276	49	;	;	PUNCT
eurjchem-2350	276	50	caine	caine	PROPN
eurjchem-2350	276	51	,	,	PUNCT
eurjchem-2350	276	52	e.	e.	PROPN
eurjchem-2350	276	53	a.	a.	PROPN
eurjchem-2350	276	54	;	;	PUNCT
eurjchem-2350	276	55	osorio	osorio	PROPN
eurjchem-2350	276	56	,	,	PUNCT
eurjchem-2350	276	57	j.	j.	PROPN
eurjchem-2350	276	58	e.	e.	PROPN
eurjchem-2350	276	59	;	;	PUNCT
eurjchem-2350	276	60	bellio	bellio	PROPN
eurjchem-2350	276	61	,	,	PUNCT
eurjchem-2350	276	62	m.	m.	NOUN
eurjchem-2350	276	63	;	;	PUNCT
eurjchem-2350	276	64	o’connor	o’connor	ADV
eurjchem-2350	276	65	,	,	PUNCT
eurjchem-2350	276	66	d.	d.	PROPN
eurjchem-2350	276	67	h.	h.	PROPN
eurjchem-2350	276	68	;	;	PUNCT
eurjchem-2350	276	69	rehen	rehen	PROPN
eurjchem-2350	276	70	,	,	PUNCT
eurjchem-2350	276	71	s.	s.	PROPN
eurjchem-2350	276	72	;	;	PUNCT
eurjchem-2350	276	73	de	de	X
eurjchem-2350	276	74	aguiar	aguiar	PROPN
eurjchem-2350	276	75	,	,	PUNCT
eurjchem-2350	276	76	r.	r.	PROPN
eurjchem-2350	276	77	s.	s.	PROPN
eurjchem-2350	276	78	;	;	PUNCT
eurjchem-2350	276	79	savarino	savarino	PROPN
eurjchem-2350	276	80	,	,	PUNCT
eurjchem-2350	276	81	a.	a.	NOUN
eurjchem-2350	276	82	;	;	PUNCT
eurjchem-2350	277	1	campanati	campanati	NOUN
eurjchem-2350	277	2	,	,	PUNCT
eurjchem-2350	277	3	l.	l.	PROPN
eurjchem-2350	277	4	;	;	PUNCT
eurjchem-2350	277	5	tanuri	tanuri	PROPN
eurjchem-2350	277	6	,	,	PUNCT
eurjchem-2350	277	7	a.	a.	NOUN
eurjchem-2350	277	8	chloroquine	chloroquine	PROPN
eurjchem-2350	277	9	,	,	PUNCT
eurjchem-2350	277	10	an	an	DET
eurjchem-2350	277	11	endocytosis	endocytosis	NOUN
eurjchem-2350	277	12	blocking	block	VERB
eurjchem-2350	277	13	agent	agent	NOUN
eurjchem-2350	277	14	,	,	PUNCT
eurjchem-2350	277	15	inhibits	inhibit	VERB
eurjchem-2350	277	16	zika	zika	NOUN
eurjchem-2350	277	17	virus	virus	NOUN
eurjchem-2350	277	18	infection	infection	NOUN
eurjchem-2350	277	19	in	in	ADP
eurjchem-2350	277	20	different	different	ADJ
eurjchem-2350	277	21	cell	cell	NOUN
eurjchem-2350	277	22	models	model	NOUN
eurjchem-2350	277	23	.	.	PUNCT
eurjchem-2350	278	1	viruses	virus	NOUN
eurjchem-2350	278	2	2016	2016	NUM
eurjchem-2350	278	3	,	,	PUNCT
eurjchem-2350	278	4	8	8	NUM
eurjchem-2350	278	5	(	(	PUNCT
eurjchem-2350	278	6	12	12	NUM
eurjchem-2350	278	7	)	)	PUNCT
eurjchem-2350	278	8	,	,	PUNCT
eurjchem-2350	278	9	322	322	NUM
eurjchem-2350	278	10	.	.	PUNCT
eurjchem-2350	278	11	https://doi.org/10.3390/v8120322	https://doi.org/10.3390/v8120322	PRON
eurjchem-2350	278	12	.	.	PUNCT
eurjchem-2350	279	1	[	[	X
eurjchem-2350	279	2	18	18	NUM
eurjchem-2350	279	3	]	]	PUNCT
eurjchem-2350	279	4	.	.	PUNCT
eurjchem-2350	280	1	dowall	dowall	PROPN
eurjchem-2350	280	2	,	,	PUNCT
eurjchem-2350	280	3	s.	s.	PROPN
eurjchem-2350	280	4	d.	d.	PROPN
eurjchem-2350	280	5	;	;	PUNCT
eurjchem-2350	280	6	bosworth	bosworth	PROPN
eurjchem-2350	280	7	,	,	PUNCT
eurjchem-2350	280	8	a.	a.	PROPN
eurjchem-2350	280	9	;	;	PUNCT
eurjchem-2350	280	10	watson	watson	PROPN
eurjchem-2350	280	11	,	,	PUNCT
eurjchem-2350	280	12	r.	r.	PROPN
eurjchem-2350	280	13	;	;	PUNCT
eurjchem-2350	280	14	bewley	bewley	PROPN
eurjchem-2350	280	15	,	,	PUNCT
eurjchem-2350	280	16	k.	k.	PROPN
eurjchem-2350	280	17	;	;	PUNCT
eurjchem-2350	280	18	taylor	taylor	PROPN
eurjchem-2350	280	19	,	,	PUNCT
eurjchem-2350	280	20	i.	i.	PROPN
eurjchem-2350	280	21	;	;	PUNCT
eurjchem-2350	280	22	rayner	rayner	PROPN
eurjchem-2350	280	23	,	,	PUNCT
eurjchem-2350	280	24	e.	e.	PROPN
eurjchem-2350	280	25	;	;	PUNCT
eurjchem-2350	280	26	hunter	hunter	NOUN
eurjchem-2350	280	27	,	,	PUNCT
eurjchem-2350	280	28	l.	l.	PROPN
eurjchem-2350	280	29	;	;	PUNCT
eurjchem-2350	280	30	pearson	pearson	PROPN
eurjchem-2350	280	31	,	,	PUNCT
eurjchem-2350	280	32	g.	g.	PROPN
eurjchem-2350	280	33	;	;	PUNCT
eurjchem-2350	280	34	easterbrook	easterbrook	PROPN
eurjchem-2350	280	35	,	,	PUNCT
eurjchem-2350	280	36	l.	l.	PROPN
eurjchem-2350	280	37	;	;	PUNCT
eurjchem-2350	280	38	pitman	pitman	PROPN
eurjchem-2350	280	39	,	,	PUNCT
eurjchem-2350	280	40	j.	j.	PROPN
eurjchem-2350	280	41	;	;	PUNCT
eurjchem-2350	280	42	hewson	hewson	PROPN
eurjchem-2350	280	43	,	,	PUNCT
eurjchem-2350	280	44	r.	r.	PROPN
eurjchem-2350	280	45	;	;	PUNCT
eurjchem-2350	280	46	carroll	carroll	PROPN
eurjchem-2350	280	47	,	,	PUNCT
eurjchem-2350	280	48	m.	m.	NOUN
eurjchem-2350	280	49	w.	w.	PROPN
eurjchem-2350	280	50	chloroquine	chloroquine	PROPN
eurjchem-2350	280	51	inhibited	inhibit	VERB
eurjchem-2350	280	52	ebola	ebola	PROPN
eurjchem-2350	280	53	virus	virus	NOUN
eurjchem-2350	280	54	replication	replication	NOUN
eurjchem-2350	280	55	in	in	ADP
eurjchem-2350	280	56	vitro	vitro	NOUN
eurjchem-2350	280	57	but	but	CCONJ
eurjchem-2350	280	58	failed	fail	VERB
eurjchem-2350	280	59	to	to	PART
eurjchem-2350	280	60	protect	protect	VERB
eurjchem-2350	280	61	against	against	ADP
eurjchem-2350	280	62	infection	infection	NOUN
eurjchem-2350	280	63	and	and	CCONJ
eurjchem-2350	280	64	disease	disease	NOUN
eurjchem-2350	280	65	in	in	ADP
eurjchem-2350	280	66	the	the	DET
eurjchem-2350	280	67	in	in	ADP
eurjchem-2350	280	68	vivo	vivo	ADJ
eurjchem-2350	280	69	guinea	guinea	NOUN
eurjchem-2350	280	70	pig	pig	NOUN
eurjchem-2350	280	71	model	model	NOUN
eurjchem-2350	280	72	.	.	PUNCT
eurjchem-2350	281	1	j.	j.	PROPN
eurjchem-2350	281	2	gen	gen	PROPN
eurjchem-2350	281	3	.	.	PROPN
eurjchem-2350	281	4	virol	virol	PROPN
eurjchem-2350	281	5	.	.	PUNCT
eurjchem-2350	282	1	2015	2015	NUM
eurjchem-2350	282	2	,	,	PUNCT
eurjchem-2350	282	3	96	96	NUM
eurjchem-2350	282	4	(	(	PUNCT
eurjchem-2350	282	5	12	12	NUM
eurjchem-2350	282	6	)	)	PUNCT
eurjchem-2350	282	7	,	,	PUNCT
eurjchem-2350	282	8	3484–3492	3484–3492	NUM
eurjchem-2350	282	9	.	.	PUNCT
eurjchem-2350	283	1	[	[	X
eurjchem-2350	283	2	19	19	NUM
eurjchem-2350	283	3	]	]	PUNCT
eurjchem-2350	283	4	.	.	PUNCT
eurjchem-2350	283	5	savarino	savarino	PROPN
eurjchem-2350	283	6	,	,	PUNCT
eurjchem-2350	283	7	a.	a.	NOUN
eurjchem-2350	283	8	;	;	PUNCT
eurjchem-2350	283	9	boelaert	boelaert	PROPN
eurjchem-2350	283	10	,	,	PUNCT
eurjchem-2350	283	11	j.	j.	PROPN
eurjchem-2350	283	12	r.	r.	PROPN
eurjchem-2350	283	13	;	;	PUNCT
eurjchem-2350	283	14	cassone	cassone	NOUN
eurjchem-2350	283	15	,	,	PUNCT
eurjchem-2350	283	16	a.	a.	NOUN
eurjchem-2350	283	17	;	;	PUNCT
eurjchem-2350	283	18	majori	majori	PROPN
eurjchem-2350	283	19	,	,	PUNCT
eurjchem-2350	283	20	g.	g.	PROPN
eurjchem-2350	283	21	;	;	PUNCT
eurjchem-2350	283	22	cauda	cauda	PROPN
eurjchem-2350	283	23	,	,	PUNCT
eurjchem-2350	283	24	r.	r.	NOUN
eurjchem-2350	283	25	effects	effect	NOUN
eurjchem-2350	283	26	of	of	ADP
eurjchem-2350	283	27	chloroquine	chloroquine	NOUN
eurjchem-2350	283	28	on	on	ADP
eurjchem-2350	283	29	viral	viral	ADJ
eurjchem-2350	283	30	infections	infection	NOUN
eurjchem-2350	283	31	:	:	PUNCT
eurjchem-2350	283	32	an	an	DET
eurjchem-2350	283	33	old	old	ADJ
eurjchem-2350	283	34	drug	drug	NOUN
eurjchem-2350	283	35	against	against	ADP
eurjchem-2350	283	36	today	today	NOUN
eurjchem-2350	283	37	’s	’s	PART
eurjchem-2350	283	38	diseases	disease	NOUN
eurjchem-2350	283	39	?	?	PUNCT
eurjchem-2350	284	1	lancet	lancet	NOUN
eurjchem-2350	284	2	infect	infect	PROPN
eurjchem-2350	284	3	.	.	PUNCT
eurjchem-2350	285	1	dis	dis	PROPN
eurjchem-2350	285	2	.	.	PROPN
eurjchem-2350	286	1	2003	2003	NUM
eurjchem-2350	286	2	,	,	PUNCT
eurjchem-2350	286	3	3	3	NUM
eurjchem-2350	286	4	(	(	PUNCT
eurjchem-2350	286	5	11	11	NUM
eurjchem-2350	286	6	)	)	PUNCT
eurjchem-2350	286	7	,	,	PUNCT
eurjchem-2350	286	8	722–727	722–727	NUM
eurjchem-2350	286	9	.	.	PUNCT
eurjchem-2350	287	1	[	[	X
eurjchem-2350	287	2	20	20	NUM
eurjchem-2350	287	3	]	]	PUNCT
eurjchem-2350	287	4	.	.	PUNCT
eurjchem-2350	288	1	keyaerts	keyaert	NOUN
eurjchem-2350	288	2	,	,	PUNCT
eurjchem-2350	288	3	e.	e.	PROPN
eurjchem-2350	288	4	;	;	PUNCT
eurjchem-2350	288	5	li	li	PROPN
eurjchem-2350	288	6	,	,	PUNCT
eurjchem-2350	288	7	s.	s.	PROPN
eurjchem-2350	288	8	;	;	PUNCT
eurjchem-2350	288	9	vijgen	vijgen	PROPN
eurjchem-2350	288	10	,	,	PUNCT
eurjchem-2350	288	11	l.	l.	PROPN
eurjchem-2350	288	12	;	;	PUNCT
eurjchem-2350	288	13	rysman	rysman	NOUN
eurjchem-2350	288	14	,	,	PUNCT
eurjchem-2350	288	15	e.	e.	PROPN
eurjchem-2350	288	16	;	;	PUNCT
eurjchem-2350	288	17	verbeeck	verbeeck	PROPN
eurjchem-2350	288	18	,	,	PUNCT
eurjchem-2350	288	19	j.	j.	PROPN
eurjchem-2350	288	20	;	;	PUNCT
eurjchem-2350	288	21	van	van	PROPN
eurjchem-2350	288	22	ranst	ranst	NOUN
eurjchem-2350	288	23	,	,	PUNCT
eurjchem-2350	288	24	m.	m.	NOUN
eurjchem-2350	288	25	;	;	PUNCT
eurjchem-2350	288	26	maes	maes	PROPN
eurjchem-2350	288	27	,	,	PUNCT
eurjchem-2350	288	28	p.	p.	NOUN
eurjchem-2350	288	29	antiviral	antiviral	ADJ
eurjchem-2350	288	30	activity	activity	NOUN
eurjchem-2350	288	31	of	of	ADP
eurjchem-2350	288	32	chloroquine	chloroquine	NOUN
eurjchem-2350	288	33	against	against	ADP
eurjchem-2350	288	34	human	human	ADJ
eurjchem-2350	288	35	coronavirus	coronavirus	NOUN
eurjchem-2350	288	36	oc43	oc43	PROPN
eurjchem-2350	288	37	infection	infection	NOUN
eurjchem-2350	288	38	in	in	ADP
eurjchem-2350	288	39	newborn	newborn	ADJ
eurjchem-2350	288	40	mice	mouse	NOUN
eurjchem-2350	288	41	.	.	PUNCT
eurjchem-2350	289	1	antimicrob	antimicrob	PROPN
eurjchem-2350	289	2	.	.	PUNCT
eurjchem-2350	290	1	agents	agents	PROPN
eurjchem-2350	290	2	chemother	chemother	PROPN
eurjchem-2350	290	3	.	.	PUNCT
eurjchem-2350	291	1	2009	2009	NUM
eurjchem-2350	291	2	,	,	PUNCT
eurjchem-2350	291	3	53	53	NUM
eurjchem-2350	291	4	(	(	PUNCT
eurjchem-2350	291	5	8)	8)	NUM
eurjchem-2350	291	6	,	,	PUNCT
eurjchem-2350	291	7	3416–3421	3416–3421	NUM
eurjchem-2350	291	8	.	.	PUNCT
eurjchem-2350	292	1	[	[	X
eurjchem-2350	292	2	21	21	NUM
eurjchem-2350	292	3	]	]	PUNCT
eurjchem-2350	292	4	.	.	PUNCT
eurjchem-2350	293	1	cortegiani	cortegiani	PROPN
eurjchem-2350	293	2	,	,	PUNCT
eurjchem-2350	293	3	a.	a.	NOUN
eurjchem-2350	293	4	;	;	PUNCT
eurjchem-2350	293	5	ingoglia	ingoglia	PROPN
eurjchem-2350	293	6	,	,	PUNCT
eurjchem-2350	293	7	g.	g.	PROPN
eurjchem-2350	293	8	;	;	PUNCT
eurjchem-2350	293	9	ippolito	ippolito	PROPN
eurjchem-2350	293	10	,	,	PUNCT
eurjchem-2350	293	11	m.	m.	NOUN
eurjchem-2350	293	12	;	;	PUNCT
eurjchem-2350	293	13	giarratano	giarratano	NOUN
eurjchem-2350	293	14	,	,	PUNCT
eurjchem-2350	293	15	a.	a.	NOUN
eurjchem-2350	293	16	;	;	PUNCT
eurjchem-2350	293	17	einav	einav	NOUN
eurjchem-2350	293	18	,	,	PUNCT
eurjchem-2350	293	19	s.	s.	PROPN
eurjchem-2350	293	20	a	a	DET
eurjchem-2350	293	21	systematic	systematic	ADJ
eurjchem-2350	293	22	review	review	NOUN
eurjchem-2350	293	23	on	on	ADP
eurjchem-2350	293	24	the	the	DET
eurjchem-2350	293	25	efficacy	efficacy	NOUN
eurjchem-2350	293	26	and	and	CCONJ
eurjchem-2350	293	27	safety	safety	NOUN
eurjchem-2350	293	28	of	of	ADP
eurjchem-2350	293	29	chloroquine	chloroquine	NOUN
eurjchem-2350	293	30	for	for	ADP
eurjchem-2350	293	31	the	the	DET
eurjchem-2350	293	32	treatment	treatment	NOUN
eurjchem-2350	293	33	of	of	ADP
eurjchem-2350	293	34	covid-19	covid-19	PROPN
eurjchem-2350	293	35	.	.	PUNCT
eurjchem-2350	294	1	j.	j.	PROPN
eurjchem-2350	294	2	crit	crit	PROPN
eurjchem-2350	294	3	.	.	PUNCT
eurjchem-2350	295	1	care	care	PROPN
eurjchem-2350	295	2	2020	2020	NUM
eurjchem-2350	295	3	,	,	PUNCT
eurjchem-2350	295	4	57	57	NUM
eurjchem-2350	295	5	,	,	PUNCT
eurjchem-2350	295	6	279–283	279–283	NUM
eurjchem-2350	295	7	.	.	PUNCT
eurjchem-2350	296	1	[	[	X
eurjchem-2350	296	2	22	22	NUM
eurjchem-2350	296	3	]	]	PUNCT
eurjchem-2350	296	4	.	.	PUNCT
eurjchem-2350	297	1	fadelelmoula	fadelelmoula	PROPN
eurjchem-2350	297	2	,	,	PUNCT
eurjchem-2350	297	3	t.	t.	NOUN
eurjchem-2350	297	4	efficacy	efficacy	NOUN
eurjchem-2350	297	5	and	and	CCONJ
eurjchem-2350	297	6	safety	safety	NOUN
eurjchem-2350	297	7	of	of	ADP
eurjchem-2350	297	8	hydroxychloroquine	hydroxychloroquine	NOUN
eurjchem-2350	297	9	in	in	ADP
eurjchem-2350	297	10	treating	treat	VERB
eurjchem-2350	297	11	covid-19	covid-19	PROPN
eurjchem-2350	297	12	pneumonia	pneumonia	NOUN
eurjchem-2350	297	13	:	:	PUNCT
eurjchem-2350	297	14	uncertainty	uncertainty	NOUN
eurjchem-2350	297	15	of	of	ADP
eurjchem-2350	297	16	data	datum	NOUN
eurjchem-2350	297	17	and	and	CCONJ
eurjchem-2350	297	18	changing	change	VERB
eurjchem-2350	297	19	treatment	treatment	NOUN
eurjchem-2350	297	20	protocols	protocol	NOUN
eurjchem-2350	297	21	.	.	PUNCT
eurjchem-2350	298	1	j.	j.	PROPN
eurjchem-2350	298	2	lung	lung	PROPN
eurjchem-2350	298	3	pulm	pulm	NOUN
eurjchem-2350	298	4	.	.	PUNCT
eurjchem-2350	299	1	respir	respir	PROPN
eurjchem-2350	299	2	.	.	PUNCT
eurjchem-2350	300	1	res	re	NOUN
eurjchem-2350	300	2	.	.	PUNCT
eurjchem-2350	301	1	2020	2020	NUM
eurjchem-2350	301	2	,	,	PUNCT
eurjchem-2350	301	3	7	7	NUM
eurjchem-2350	301	4	(	(	PUNCT
eurjchem-2350	301	5	2	2	NUM
eurjchem-2350	301	6	)	)	PUNCT
eurjchem-2350	301	7	,	,	PUNCT
eurjchem-2350	301	8	62–65	62–65	NUM
eurjchem-2350	301	9	.	.	PUNCT
eurjchem-2350	302	1	[	[	X
eurjchem-2350	302	2	23	23	NUM
eurjchem-2350	302	3	]	]	PUNCT
eurjchem-2350	302	4	.	.	PUNCT
eurjchem-2350	303	1	wu	wu	PROPN
eurjchem-2350	303	2	,	,	PUNCT
eurjchem-2350	303	3	t.	t.	PROPN
eurjchem-2350	303	4	;	;	PUNCT
eurjchem-2350	303	5	li	li	PROPN
eurjchem-2350	303	6	,	,	PUNCT
eurjchem-2350	303	7	y.	y.	PROPN
eurjchem-2350	303	8	;	;	PUNCT
eurjchem-2350	303	9	liu	liu	PROPN
eurjchem-2350	303	10	,	,	PUNCT
eurjchem-2350	303	11	g.	g.	PROPN
eurjchem-2350	303	12	;	;	PUNCT
eurjchem-2350	303	13	li	li	PROPN
eurjchem-2350	303	14	,	,	PUNCT
eurjchem-2350	303	15	j.	j.	PROPN
eurjchem-2350	303	16	;	;	PUNCT
eurjchem-2350	303	17	wang	wang	PROPN
eurjchem-2350	303	18	,	,	PUNCT
eurjchem-2350	303	19	l.	l.	PROPN
eurjchem-2350	303	20	;	;	PUNCT
eurjchem-2350	303	21	du	du	PROPN
eurjchem-2350	303	22	,	,	PUNCT
eurjchem-2350	303	23	l.	l.	PROPN
eurjchem-2350	303	24	;	;	PUNCT
eurjchem-2350	303	25	chinese	chinese	ADJ
eurjchem-2350	303	26	clinical	clinical	ADJ
eurjchem-2350	303	27	registry	registry	NOUN
eurjchem-2350	303	28	.	.	PUNCT
eurjchem-2350	304	1	chinese	chinese	ADJ
eurjchem-2350	304	2	clinical	clinical	ADJ
eurjchem-2350	304	3	trial	trial	NOUN
eurjchem-2350	304	4	registry	registry	NOUN
eurjchem-2350	304	5	:	:	PUNCT
eurjchem-2350	304	6	mission	mission	NOUN
eurjchem-2350	304	7	,	,	PUNCT
eurjchem-2350	304	8	responsibility	responsibility	NOUN
eurjchem-2350	304	9	and	and	CCONJ
eurjchem-2350	304	10	operation	operation	NOUN
eurjchem-2350	304	11	:	:	PUNCT
eurjchem-2350	305	1	chinese	chinese	ADJ
eurjchem-2350	305	2	clinical	clinical	ADJ
eurjchem-2350	305	3	trial	trial	NOUN
eurjchem-2350	305	4	registry	registry	NOUN
eurjchem-2350	305	5	:	:	PUNCT
eurjchem-2350	305	6	mission	mission	NOUN
eurjchem-2350	305	7	,	,	PUNCT
eurjchem-2350	305	8	responsibility	responsibility	NOUN
eurjchem-2350	305	9	and	and	CCONJ
eurjchem-2350	305	10	operation	operation	NOUN
eurjchem-2350	305	11	.	.	PUNCT
eurjchem-2350	306	1	j.	j.	PROPN
eurjchem-2350	306	2	evid	evid	PROPN
eurjchem-2350	306	3	.	.	PUNCT
eurjchem-2350	307	1	based	base	VERB
eurjchem-2350	307	2	med	med	PROPN
eurjchem-2350	307	3	.	.	PUNCT
eurjchem-2350	308	1	2011	2011	NUM
eurjchem-2350	308	2	,	,	PUNCT
eurjchem-2350	308	3	4	4	NUM
eurjchem-2350	308	4	(	(	PUNCT
eurjchem-2350	308	5	3	3	NUM
eurjchem-2350	308	6	)	)	PUNCT
eurjchem-2350	308	7	,	,	PUNCT
eurjchem-2350	308	8	165–167	165–167	NUM
eurjchem-2350	308	9	.	.	PUNCT
eurjchem-2350	309	1	[	[	X
eurjchem-2350	309	2	24	24	NUM
eurjchem-2350	309	3	]	]	PUNCT
eurjchem-2350	309	4	.	.	PUNCT
eurjchem-2350	310	1	liu	liu	PROPN
eurjchem-2350	310	2	,	,	PUNCT
eurjchem-2350	310	3	j.	j.	PROPN
eurjchem-2350	310	4	;	;	PUNCT
eurjchem-2350	310	5	cao	cao	PROPN
eurjchem-2350	310	6	,	,	PUNCT
eurjchem-2350	310	7	r.	r.	PROPN
eurjchem-2350	310	8	;	;	PUNCT
eurjchem-2350	310	9	xu	xu	PROPN
eurjchem-2350	310	10	,	,	PUNCT
eurjchem-2350	310	11	m.	m.	NOUN
eurjchem-2350	310	12	;	;	PUNCT
eurjchem-2350	310	13	wang	wang	PROPN
eurjchem-2350	310	14	,	,	PUNCT
eurjchem-2350	310	15	x.	x.	PROPN
eurjchem-2350	310	16	;	;	PUNCT
eurjchem-2350	310	17	zhang	zhang	PROPN
eurjchem-2350	310	18	,	,	PUNCT
eurjchem-2350	310	19	h.	h.	PROPN
eurjchem-2350	310	20	;	;	PUNCT
eurjchem-2350	310	21	hu	hu	PROPN
eurjchem-2350	310	22	,	,	PUNCT
eurjchem-2350	310	23	h.	h.	PROPN
eurjchem-2350	310	24	;	;	PUNCT
eurjchem-2350	310	25	li	li	PROPN
eurjchem-2350	310	26	,	,	PUNCT
eurjchem-2350	310	27	y.	y.	PROPN
eurjchem-2350	310	28	;	;	PUNCT
eurjchem-2350	310	29	hu	hu	PROPN
eurjchem-2350	310	30	,	,	PUNCT
eurjchem-2350	310	31	z.	z.	PROPN
eurjchem-2350	310	32	;	;	PUNCT
eurjchem-2350	310	33	zhong	zhong	PROPN
eurjchem-2350	310	34	,	,	PUNCT
eurjchem-2350	310	35	w.	w.	PROPN
eurjchem-2350	310	36	;	;	PUNCT
eurjchem-2350	310	37	wang	wang	PROPN
eurjchem-2350	310	38	,	,	PUNCT
eurjchem-2350	310	39	m.	m.	PROPN
eurjchem-2350	310	40	hydroxychloroquine	hydroxychloroquine	PROPN
eurjchem-2350	310	41	,	,	PUNCT
eurjchem-2350	310	42	a	a	DET
eurjchem-2350	310	43	less	less	ADV
eurjchem-2350	310	44	toxic	toxic	ADJ
eurjchem-2350	310	45	derivative	derivative	NOUN
eurjchem-2350	310	46	of	of	ADP
eurjchem-2350	310	47	chloroquine	chloroquine	NOUN
eurjchem-2350	310	48	,	,	PUNCT
eurjchem-2350	310	49	is	be	AUX
eurjchem-2350	310	50	effective	effective	ADJ
eurjchem-2350	310	51	in	in	ADP
eurjchem-2350	310	52	inhibiting	inhibit	VERB
eurjchem-2350	310	53	sars	sar	NOUN
eurjchem-2350	310	54	-	-	PUNCT
eurjchem-2350	310	55	cov-2	cov-2	NOUN
eurjchem-2350	310	56	infection	infection	NOUN
eurjchem-2350	310	57	in	in	ADP
eurjchem-2350	310	58	vitro	vitro	X
eurjchem-2350	310	59	.	.	PUNCT
eurjchem-2350	311	1	cell	cell	NOUN
eurjchem-2350	311	2	discov	discov	NOUN
eurjchem-2350	311	3	.	.	PUNCT
eurjchem-2350	312	1	2020	2020	NUM
eurjchem-2350	312	2	,	,	PUNCT
eurjchem-2350	312	3	6	6	NUM
eurjchem-2350	312	4	(	(	PUNCT
eurjchem-2350	312	5	1	1	NUM
eurjchem-2350	312	6	)	)	PUNCT
eurjchem-2350	312	7	,	,	PUNCT
eurjchem-2350	312	8	16	16	NUM
eurjchem-2350	312	9	.	.	PUNCT
eurjchem-2350	313	1	[	[	X
eurjchem-2350	313	2	25	25	NUM
eurjchem-2350	313	3	]	]	PUNCT
eurjchem-2350	313	4	.	.	PUNCT
eurjchem-2350	313	5	khuroo	khuroo	PROPN
eurjchem-2350	313	6	,	,	PUNCT
eurjchem-2350	313	7	m.	m.	NOUN
eurjchem-2350	313	8	s.	s.	PROPN
eurjchem-2350	313	9	chloroquine	chloroquine	PROPN
eurjchem-2350	313	10	and	and	CCONJ
eurjchem-2350	313	11	hydroxychloroquine	hydroxychloroquine	PROPN
eurjchem-2350	313	12	in	in	ADP
eurjchem-2350	313	13	coronavirus	coronavirus	NOUN
eurjchem-2350	313	14	disease	disease	NOUN
eurjchem-2350	313	15	2019	2019	NUM
eurjchem-2350	313	16	(	(	PUNCT
eurjchem-2350	313	17	covid-19	covid-19	PROPN
eurjchem-2350	313	18	)	)	PUNCT
eurjchem-2350	313	19	.	.	PUNCT
eurjchem-2350	314	1	facts	fact	NOUN
eurjchem-2350	314	2	,	,	PUNCT
eurjchem-2350	314	3	fiction	fiction	NOUN
eurjchem-2350	314	4	and	and	CCONJ
eurjchem-2350	314	5	the	the	DET
eurjchem-2350	314	6	hype	hype	NOUN
eurjchem-2350	314	7	:	:	PUNCT
eurjchem-2350	314	8	a	a	DET
eurjchem-2350	314	9	critical	critical	ADJ
eurjchem-2350	314	10	appraisal	appraisal	NOUN
eurjchem-2350	314	11	.	.	PUNCT
eurjchem-2350	315	1	int	int	NOUN
eurjchem-2350	315	2	.	.	PUNCT
eurjchem-2350	316	1	j.	j.	PROPN
eurjchem-2350	316	2	antimicrob	antimicrob	PROPN
eurjchem-2350	316	3	.	.	PUNCT
eurjchem-2350	317	1	agents	agent	NOUN
eurjchem-2350	317	2	2020	2020	NUM
eurjchem-2350	317	3	,	,	PUNCT
eurjchem-2350	317	4	56	56	NUM
eurjchem-2350	317	5	,	,	PUNCT
eurjchem-2350	317	6	106101	106101	NUM
eurjchem-2350	317	7	.	.	PUNCT
eurjchem-2350	318	1	[	[	X
eurjchem-2350	318	2	26	26	NUM
eurjchem-2350	318	3	]	]	PUNCT
eurjchem-2350	318	4	.	.	PUNCT
eurjchem-2350	319	1	rodriguez	rodriguez	NOUN
eurjchem-2350	319	2	-	-	PUNCT
eurjchem-2350	319	3	valero	valero	PROPN
eurjchem-2350	319	4	,	,	PUNCT
eurjchem-2350	319	5	n.	n.	NOUN
eurjchem-2350	319	6	;	;	PUNCT
eurjchem-2350	319	7	vera	vera	NOUN
eurjchem-2350	319	8	,	,	PUNCT
eurjchem-2350	319	9	i.	i.	NOUN
eurjchem-2350	319	10	;	;	PUNCT
eurjchem-2350	319	11	torralvo	torralvo	NUM
eurjchem-2350	319	12	,	,	PUNCT
eurjchem-2350	319	13	m.	m.	PROPN
eurjchem-2350	319	14	r.	r.	PROPN
eurjchem-2350	319	15	;	;	PUNCT
eurjchem-2350	319	16	de	de	PROPN
eurjchem-2350	319	17	alba	alba	PROPN
eurjchem-2350	319	18	,	,	PUNCT
eurjchem-2350	319	19	t.	t.	PROPN
eurjchem-2350	319	20	;	;	PUNCT
eurjchem-2350	319	21	ferrer	ferrer	PROPN
eurjchem-2350	319	22	,	,	PUNCT
eurjchem-2350	319	23	e.	e.	PROPN
eurjchem-2350	319	24	;	;	PUNCT
eurjchem-2350	319	25	camprubi	camprubi	PROPN
eurjchem-2350	319	26	,	,	PUNCT
eurjchem-2350	319	27	d.	d.	PROPN
eurjchem-2350	319	28	;	;	PUNCT
eurjchem-2350	319	29	almuedoriera	almuedoriera	NOUN
eurjchem-2350	319	30	,	,	PUNCT
eurjchem-2350	319	31	a.	a.	NOUN
eurjchem-2350	319	32	;	;	PUNCT
eurjchem-2350	319	33	gallego	gallego	NOUN
eurjchem-2350	319	34	,	,	PUNCT
eurjchem-2350	319	35	r.	r.	PROPN
eurjchem-2350	319	36	s.	s.	PROPN
eurjchem-2350	319	37	;	;	PUNCT
eurjchem-2350	319	38	muelas	muela	NOUN
eurjchem-2350	319	39	,	,	PUNCT
eurjchem-2350	319	40	m.	m.	NOUN
eurjchem-2350	319	41	;	;	PUNCT
eurjchem-2350	319	42	pinazo	pinazo	NOUN
eurjchem-2350	319	43	,	,	PUNCT
eurjchem-2350	319	44	m.	m.	PROPN
eurjchem-2350	319	45	j.	j.	PROPN
eurjchem-2350	319	46	;	;	PUNCT
eurjchem-2350	319	47	muñoz	muñoz	PROPN
eurjchem-2350	319	48	,	,	PUNCT
eurjchem-2350	319	49	j.	j.	PROPN
eurjchem-2350	319	50	malaria	malaria	PROPN
eurjchem-2350	319	51	prophylaxis	prophylaxis	PROPN
eurjchem-2350	319	52	approach	approach	NOUN
eurjchem-2350	319	53	during	during	ADP
eurjchem-2350	319	54	covid-19	covid-19	PROPN
eurjchem-2350	319	55	pandemic	pandemic	NOUN
eurjchem-2350	319	56	.	.	PUNCT
eurjchem-2350	320	1	travel	travel	NOUN
eurjchem-2350	320	2	med	me	VERB
eurjchem-2350	320	3	.	.	PUNCT
eurjchem-2350	321	1	infect	infect	VERB
eurjchem-2350	321	2	.	.	PUNCT
eurjchem-2350	322	1	dis	dis	PROPN
eurjchem-2350	322	2	.	.	PUNCT
eurjchem-2350	323	1	2020	2020	NUM
eurjchem-2350	323	2	,	,	PUNCT
eurjchem-2350	323	3	38	38	NUM
eurjchem-2350	323	4	(	(	PUNCT
eurjchem-2350	323	5	101716	101716	NUM
eurjchem-2350	323	6	)	)	PUNCT
eurjchem-2350	323	7	,	,	PUNCT
eurjchem-2350	323	8	101716	101716	NUM
eurjchem-2350	323	9	.	.	PUNCT
eurjchem-2350	324	1	[	[	X
eurjchem-2350	324	2	27	27	NUM
eurjchem-2350	324	3	]	]	PUNCT
eurjchem-2350	324	4	.	.	PUNCT
eurjchem-2350	325	1	wu	wu	PROPN
eurjchem-2350	325	2	,	,	PUNCT
eurjchem-2350	325	3	c.	c.	PROPN
eurjchem-2350	325	4	;	;	PUNCT
eurjchem-2350	325	5	liu	liu	PROPN
eurjchem-2350	325	6	,	,	PUNCT
eurjchem-2350	325	7	y.	y.	PROPN
eurjchem-2350	325	8	;	;	PUNCT
eurjchem-2350	325	9	yang	yang	PROPN
eurjchem-2350	325	10	,	,	PUNCT
eurjchem-2350	325	11	y.	y.	PROPN
eurjchem-2350	325	12	;	;	PUNCT
eurjchem-2350	325	13	zhang	zhang	PROPN
eurjchem-2350	325	14	,	,	PUNCT
eurjchem-2350	325	15	p.	p.	PROPN
eurjchem-2350	325	16	;	;	PUNCT
eurjchem-2350	325	17	zhong	zhong	PROPN
eurjchem-2350	325	18	,	,	PUNCT
eurjchem-2350	325	19	w.	w.	PROPN
eurjchem-2350	325	20	;	;	PUNCT
eurjchem-2350	325	21	wang	wang	PROPN
eurjchem-2350	325	22	,	,	PUNCT
eurjchem-2350	325	23	y.	y.	PROPN
eurjchem-2350	325	24	;	;	PUNCT
eurjchem-2350	325	25	wang	wang	PROPN
eurjchem-2350	325	26	,	,	PUNCT
eurjchem-2350	325	27	q.	q.	PROPN
eurjchem-2350	325	28	;	;	PUNCT
eurjchem-2350	325	29	xu	xu	PROPN
eurjchem-2350	325	30	,	,	PUNCT
eurjchem-2350	325	31	y.	y.	PROPN
eurjchem-2350	325	32	;	;	PUNCT
eurjchem-2350	325	33	li	li	PROPN
eurjchem-2350	325	34	,	,	PUNCT
eurjchem-2350	325	35	m.	m.	NOUN
eurjchem-2350	325	36	;	;	PUNCT
eurjchem-2350	325	37	li	li	PROPN
eurjchem-2350	325	38	,	,	PUNCT
eurjchem-2350	325	39	x.	x.	PROPN
eurjchem-2350	325	40	;	;	PUNCT
eurjchem-2350	325	41	zheng	zheng	PROPN
eurjchem-2350	325	42	,	,	PUNCT
eurjchem-2350	325	43	m.	m.	NOUN
eurjchem-2350	325	44	;	;	PUNCT
eurjchem-2350	325	45	chen	chen	PROPN
eurjchem-2350	325	46	,	,	PUNCT
eurjchem-2350	325	47	l.	l.	PROPN
eurjchem-2350	325	48	;	;	PUNCT
eurjchem-2350	325	49	li	li	PROPN
eurjchem-2350	325	50	,	,	PUNCT
eurjchem-2350	325	51	h.	h.	NOUN
eurjchem-2350	325	52	analysis	analysis	NOUN
eurjchem-2350	325	53	of	of	ADP
eurjchem-2350	325	54	therapeutic	therapeutic	ADJ
eurjchem-2350	325	55	targets	target	NOUN
eurjchem-2350	325	56	for	for	ADP
eurjchem-2350	325	57	sars	sar	NOUN
eurjchem-2350	325	58	-	-	PUNCT
eurjchem-2350	325	59	cov-2	cov-2	PART
eurjchem-2350	325	60	and	and	CCONJ
eurjchem-2350	325	61	discovery	discovery	NOUN
eurjchem-2350	325	62	of	of	ADP
eurjchem-2350	325	63	potential	potential	ADJ
eurjchem-2350	325	64	drugs	drug	NOUN
eurjchem-2350	325	65	by	by	ADP
eurjchem-2350	325	66	computational	computational	ADJ
eurjchem-2350	325	67	methods	method	NOUN
eurjchem-2350	325	68	.	.	PUNCT
eurjchem-2350	326	1	acta	acta	PROPN
eurjchem-2350	326	2	pharm	pharm	PROPN
eurjchem-2350	326	3	.	.	PUNCT
eurjchem-2350	327	1	sin	sin	PROPN
eurjchem-2350	327	2	.	.	PUNCT
eurjchem-2350	328	1	b.	b.	PROPN
eurjchem-2350	328	2	2020	2020	NUM
eurjchem-2350	328	3	,	,	PUNCT
eurjchem-2350	328	4	10	10	NUM
eurjchem-2350	328	5	,	,	PUNCT
eurjchem-2350	328	6	766–788	766–788	NUM
eurjchem-2350	328	7	.	.	PUNCT
eurjchem-2350	329	1	[	[	X
eurjchem-2350	329	2	28	28	NUM
eurjchem-2350	329	3	]	]	PUNCT
eurjchem-2350	329	4	.	.	PUNCT
eurjchem-2350	330	1	kumar	kumar	PROPN
eurjchem-2350	330	2	,	,	PUNCT
eurjchem-2350	330	3	p.	p.	PROPN
eurjchem-2350	330	4	;	;	PUNCT
eurjchem-2350	330	5	uthaiah	uthaiah	PROPN
eurjchem-2350	330	6	,	,	PUNCT
eurjchem-2350	330	7	c.	c.	PROPN
eurjchem-2350	330	8	a.	a.	PROPN
eurjchem-2350	330	9	;	;	PUNCT
eurjchem-2350	330	10	mahantheshappa	mahantheshappa	PROPN
eurjchem-2350	330	11	,	,	PUNCT
eurjchem-2350	330	12	s.	s.	PROPN
eurjchem-2350	330	13	s.	s.	PROPN
eurjchem-2350	330	14	;	;	PUNCT
eurjchem-2350	330	15	satyanarayan	satyanarayan	ADJ
eurjchem-2350	330	16	,	,	PUNCT
eurjchem-2350	330	17	n.	n.	PROPN
eurjchem-2350	330	18	d.	d.	PROPN
eurjchem-2350	330	19	;	;	PUNCT
eurjchem-2350	330	20	madhunapantula	madhunapantula	PROPN
eurjchem-2350	330	21	,	,	PUNCT
eurjchem-2350	330	22	s.	s.	PROPN
eurjchem-2350	330	23	v.	v.	PROPN
eurjchem-2350	330	24	;	;	PUNCT
eurjchem-2350	330	25	kumar	kumar	PROPN
eurjchem-2350	330	26	,	,	PUNCT
eurjchem-2350	330	27	h.	h.	PROPN
eurjchem-2350	330	28	s.	s.	PROPN
eurjchem-2350	330	29	s.	s.	PROPN
eurjchem-2350	330	30	;	;	PUNCT
eurjchem-2350	330	31	achur	achur	NOUN
eurjchem-2350	330	32	,	,	PUNCT
eurjchem-2350	330	33	r.	r.	PROPN
eurjchem-2350	330	34	antiproliferative	antiproliferative	PROPN
eurjchem-2350	330	35	potential	potential	NOUN
eurjchem-2350	330	36	,	,	PUNCT
eurjchem-2350	330	37	quantitative	quantitative	ADJ
eurjchem-2350	330	38	structure	structure	NOUN
eurjchem-2350	330	39	-	-	PUNCT
eurjchem-2350	330	40	activity	activity	NOUN
eurjchem-2350	330	41	relationship	relationship	NOUN
eurjchem-2350	330	42	,	,	PUNCT
eurjchem-2350	330	43	cheminfor	cheminfor	NOUN
eurjchem-2350	330	44	matic	matic	ADJ
eurjchem-2350	330	45	and	and	CCONJ
eurjchem-2350	330	46	molecular	molecular	ADJ
eurjchem-2350	330	47	docking	docking	NOUN
eurjchem-2350	330	48	analysis	analysis	NOUN
eurjchem-2350	330	49	of	of	ADP
eurjchem-2350	330	50	quinoline	quinoline	NOUN
eurjchem-2350	330	51	and	and	CCONJ
eurjchem-2350	330	52	benzofuran	benzofuran	ADJ
eurjchem-2350	330	53	derivatives	derivative	NOUN
eurjchem-2350	330	54	.	.	PUNCT
eurjchem-2350	331	1	eur	eur	PROPN
eurjchem-2350	331	2	.	.	PUNCT
eurjchem-2350	332	1	j.	j.	PROPN
eurjchem-2350	332	2	chem	chem	PROPN
eurjchem-2350	332	3	.	.	PUNCT
eurjchem-2350	333	1	2020	2020	NUM
eurjchem-2350	333	2	,	,	PUNCT
eurjchem-2350	333	3	11	11	NUM
eurjchem-2350	333	4	(	(	PUNCT
eurjchem-2350	333	5	3	3	NUM
eurjchem-2350	333	6	)	)	PUNCT
eurjchem-2350	333	7	,	,	PUNCT
eurjchem-2350	333	8	223–234	223–234	NUM
eurjchem-2350	333	9	.	.	PUNCT
eurjchem-2350	334	1	[	[	X
eurjchem-2350	334	2	29	29	NUM
eurjchem-2350	334	3	]	]	PUNCT
eurjchem-2350	334	4	.	.	PUNCT
eurjchem-2350	335	1	mahantheshappa	mahantheshappa	PROPN
eurjchem-2350	335	2	,	,	PUNCT
eurjchem-2350	335	3	s.	s.	PROPN
eurjchem-2350	335	4	s.	s.	PROPN
eurjchem-2350	335	5	;	;	PUNCT
eurjchem-2350	335	6	shivanna	shivanna	NOUN
eurjchem-2350	335	7	,	,	PUNCT
eurjchem-2350	335	8	h.	h.	PROPN
eurjchem-2350	335	9	;	;	PUNCT
eurjchem-2350	335	10	satyanarayan	satyanarayan	ADJ
eurjchem-2350	335	11	,	,	PUNCT
eurjchem-2350	335	12	n.	n.	PROPN
eurjchem-2350	335	13	d.	d.	PROPN
eurjchem-2350	335	14	synthesis	synthesis	PROPN
eurjchem-2350	335	15	,	,	PUNCT
eurjchem-2350	335	16	antimicrobial	antimicrobial	ADJ
eurjchem-2350	335	17	,	,	PUNCT
eurjchem-2350	335	18	antioxidant	antioxidant	NOUN
eurjchem-2350	335	19	,	,	PUNCT
eurjchem-2350	335	20	and	and	CCONJ
eurjchem-2350	335	21	admet	admet	PROPN
eurjchem-2350	335	22	studies	study	NOUN
eurjchem-2350	335	23	of	of	ADP
eurjchem-2350	335	24	quinoline	quinoline	NOUN
eurjchem-2350	335	25	derivatives	derivative	NOUN
eurjchem-2350	335	26	.	.	PUNCT
eurjchem-2350	336	1	eur	eur	PROPN
eurjchem-2350	336	2	.	.	PUNCT
eurjchem-2350	337	1	j.	j.	PROPN
eurjchem-2350	337	2	chem	chem	PROPN
eurjchem-2350	337	3	.	.	PUNCT
eurjchem-2350	338	1	2021	2021	NUM
eurjchem-2350	338	2	,	,	PUNCT
eurjchem-2350	338	3	12	12	NUM
eurjchem-2350	338	4	(	(	PUNCT
eurjchem-2350	338	5	1	1	NUM
eurjchem-2350	338	6	)	)	PUNCT
eurjchem-2350	338	7	,	,	PUNCT
eurjchem-2350	338	8	37–44	37–44	NUM
eurjchem-2350	338	9	.	.	PUNCT
eurjchem-2350	339	1	[	[	X
eurjchem-2350	339	2	30	30	NUM
eurjchem-2350	339	3	]	]	PUNCT
eurjchem-2350	339	4	.	.	PUNCT
eurjchem-2350	339	5	chemaxon	chemaxon	NOUN
eurjchem-2350	339	6	software	software	NOUN
eurjchem-2350	339	7	solutions	solution	NOUN
eurjchem-2350	339	8	and	and	CCONJ
eurjchem-2350	339	9	services	service	NOUN
eurjchem-2350	339	10	for	for	ADP
eurjchem-2350	339	11	chemistry	chemistry	NOUN
eurjchem-2350	339	12	&	&	CCONJ
eurjchem-2350	339	13	biology	biology	NOUN
eurjchem-2350	339	14	,	,	PUNCT
eurjchem-2350	339	15	marvin	marvin	PROPN
eurjchem-2350	339	16	sketch.17.21.0	sketch.17.21.0	PROPN
eurjchem-2350	339	17	https://www.chemaxon.com	https://www.chemaxon.com	X
eurjchem-2350	339	18	(	(	PUNCT
eurjchem-2350	339	19	accessed	access	VERB
eurjchem-2350	339	20	jul	jul	PROPN
eurjchem-2350	339	21	15	15	NUM
eurjchem-2350	339	22	,	,	PUNCT
eurjchem-2350	339	23	2021	2021	NUM
eurjchem-2350	339	24	)	)	PUNCT
eurjchem-2350	339	25	.	.	PUNCT
eurjchem-2350	340	1	[	[	X
eurjchem-2350	340	2	31	31	NUM
eurjchem-2350	340	3	]	]	PUNCT
eurjchem-2350	340	4	.	.	PUNCT
eurjchem-2350	340	5	wishart	wishart	PROPN
eurjchem-2350	340	6	,	,	PUNCT
eurjchem-2350	340	7	d.	d.	PROPN
eurjchem-2350	340	8	s.	s.	PROPN
eurjchem-2350	340	9	;	;	PUNCT
eurjchem-2350	340	10	feunang	feunang	PROPN
eurjchem-2350	340	11	,	,	PUNCT
eurjchem-2350	340	12	y.	y.	PROPN
eurjchem-2350	340	13	d.	d.	PROPN
eurjchem-2350	340	14	;	;	PUNCT
eurjchem-2350	340	15	guo	guo	PROPN
eurjchem-2350	340	16	,	,	PUNCT
eurjchem-2350	340	17	a.	a.	PROPN
eurjchem-2350	340	18	c.	c.	PROPN
eurjchem-2350	340	19	;	;	PUNCT
eurjchem-2350	340	20	lo	lo	PROPN
eurjchem-2350	340	21	,	,	PUNCT
eurjchem-2350	340	22	e.	e.	PROPN
eurjchem-2350	340	23	j.	j.	PROPN
eurjchem-2350	340	24	;	;	PUNCT
eurjchem-2350	340	25	marcu	marcu	PROPN
eurjchem-2350	340	26	,	,	PUNCT
eurjchem-2350	340	27	a.	a.	NOUN
eurjchem-2350	340	28	;	;	PUNCT
eurjchem-2350	340	29	grant	grant	PROPN
eurjchem-2350	340	30	,	,	PUNCT
eurjchem-2350	340	31	j.	j.	PROPN
eurjchem-2350	340	32	r.	r.	PROPN
eurjchem-2350	340	33	;	;	PUNCT
eurjchem-2350	340	34	sajed	sajed	NOUN
eurjchem-2350	340	35	,	,	PUNCT
eurjchem-2350	340	36	t.	t.	PROPN
eurjchem-2350	340	37	;	;	PUNCT
eurjchem-2350	340	38	johnson	johnson	PROPN
eurjchem-2350	340	39	,	,	PUNCT
eurjchem-2350	340	40	d.	d.	PROPN
eurjchem-2350	340	41	;	;	PUNCT
eurjchem-2350	340	42	li	li	PROPN
eurjchem-2350	340	43	,	,	PUNCT
eurjchem-2350	340	44	c.	c.	PROPN
eurjchem-2350	340	45	;	;	PUNCT
eurjchem-2350	340	46	sayeeda	sayeeda	PROPN
eurjchem-2350	340	47	,	,	PUNCT
eurjchem-2350	340	48	z.	z.	PROPN
eurjchem-2350	340	49	;	;	PUNCT
eurjchem-2350	340	50	assempour	assempour	PROPN
eurjchem-2350	340	51	,	,	PUNCT
eurjchem-2350	340	52	n.	n.	NOUN
eurjchem-2350	340	53	;	;	PUNCT
eurjchem-2350	340	54	iynkkaran	iynkkaran	PROPN
eurjchem-2350	340	55	,	,	PUNCT
eurjchem-2350	340	56	i.	i.	PROPN
eurjchem-2350	340	57	;	;	PUNCT
eurjchem-2350	340	58	liu	liu	PROPN
eurjchem-2350	340	59	,	,	PUNCT
eurjchem-2350	340	60	y.	y.	PROPN
eurjchem-2350	340	61	;	;	PUNCT
eurjchem-2350	340	62	maciejewski	maciejewski	PROPN
eurjchem-2350	340	63	,	,	PUNCT
eurjchem-2350	340	64	a.	a.	NOUN
eurjchem-2350	340	65	;	;	PUNCT
eurjchem-2350	340	66	gale	gale	NOUN
eurjchem-2350	340	67	,	,	PUNCT
eurjchem-2350	340	68	n.	n.	PROPN
eurjchem-2350	340	69	;	;	PUNCT
eurjchem-2350	340	70	wilson	wilson	PROPN
eurjchem-2350	340	71	,	,	PUNCT
eurjchem-2350	340	72	a.	a.	PROPN
eurjchem-2350	340	73	;	;	PUNCT
eurjchem-2350	340	74	chin	chin	PROPN
eurjchem-2350	340	75	,	,	PUNCT
eurjchem-2350	340	76	l.	l.	PROPN
eurjchem-2350	340	77	;	;	PUNCT
eurjchem-2350	340	78	cummings	cummings	PROPN
eurjchem-2350	340	79	,	,	PUNCT
eurjchem-2350	340	80	r.	r.	PROPN
eurjchem-2350	340	81	;	;	PUNCT
eurjchem-2350	340	82	le	le	X
eurjchem-2350	340	83	,	,	PUNCT
eurjchem-2350	340	84	d.	d.	PROPN
eurjchem-2350	340	85	;	;	PUNCT
eurjchem-2350	340	86	pon	pon	PROPN
eurjchem-2350	340	87	,	,	PUNCT
eurjchem-2350	340	88	a.	a.	PROPN
eurjchem-2350	340	89	;	;	PUNCT
eurjchem-2350	340	90	knox	knox	PROPN
eurjchem-2350	340	91	,	,	PUNCT
eurjchem-2350	340	92	c.	c.	PROPN
eurjchem-2350	340	93	;	;	PUNCT
eurjchem-2350	340	94	wilson	wilson	PROPN
eurjchem-2350	340	95	,	,	PUNCT
eurjchem-2350	340	96	m.	m.	NOUN
eurjchem-2350	340	97	drugbank	drugbank	NOUN
eurjchem-2350	340	98	5.0	5.0	NUM
eurjchem-2350	340	99	:	:	PUNCT
eurjchem-2350	340	100	a	a	DET
eurjchem-2350	340	101	major	major	ADJ
eurjchem-2350	340	102	update	update	NOUN
eurjchem-2350	340	103	to	to	ADP
eurjchem-2350	340	104	the	the	DET
eurjchem-2350	340	105	drugbank	drugbank	NOUN
eurjchem-2350	340	106	database	database	NOUN
eurjchem-2350	340	107	for	for	ADP
eurjchem-2350	340	108	2018	2018	NUM
eurjchem-2350	340	109	.	.	PUNCT
eurjchem-2350	341	1	nucleic	nucleic	ADJ
eurjchem-2350	341	2	acids	acid	NOUN
eurjchem-2350	341	3	res	re	NOUN
eurjchem-2350	341	4	.	.	PROPN
eurjchem-2350	341	5	2018	2018	NUM
eurjchem-2350	341	6	,	,	PUNCT
eurjchem-2350	341	7	46	46	NUM
eurjchem-2350	341	8	(	(	PUNCT
eurjchem-2350	341	9	d1	d1	PROPN
eurjchem-2350	341	10	)	)	PUNCT
eurjchem-2350	341	11	,	,	PUNCT
eurjchem-2350	341	12	d1074	d1074	PROPN
eurjchem-2350	341	13	–	–	PUNCT
eurjchem-2350	341	14	d1082	d1082	PROPN
eurjchem-2350	341	15	.	.	PUNCT
eurjchem-2350	342	1	[	[	X
eurjchem-2350	342	2	32	32	NUM
eurjchem-2350	342	3	]	]	PUNCT
eurjchem-2350	342	4	.	.	PUNCT
eurjchem-2350	343	1	schüttelkopf	schüttelkopf	PROPN
eurjchem-2350	343	2	,	,	PUNCT
eurjchem-2350	343	3	a.	a.	PROPN
eurjchem-2350	343	4	w.	w.	PROPN
eurjchem-2350	343	5	;	;	PUNCT
eurjchem-2350	343	6	van	van	PROPN
eurjchem-2350	343	7	aalten	aalten	NOUN
eurjchem-2350	343	8	,	,	PUNCT
eurjchem-2350	343	9	d.	d.	PROPN
eurjchem-2350	343	10	m.	m.	PROPN
eurjchem-2350	343	11	f.	f.	PROPN
eurjchem-2350	343	12	prodrg	prodrg	PROPN
eurjchem-2350	343	13	:	:	PUNCT
eurjchem-2350	343	14	a	a	DET
eurjchem-2350	343	15	tool	tool	NOUN
eurjchem-2350	343	16	for	for	ADP
eurjchem-2350	343	17	highthroughput	highthroughput	VERB
eurjchem-2350	343	18	crystallography	crystallography	NOUN
eurjchem-2350	343	19	of	of	ADP
eurjchem-2350	343	20	protein	protein	NOUN
eurjchem-2350	343	21	-	-	PUNCT
eurjchem-2350	343	22	ligand	ligand	NOUN
eurjchem-2350	343	23	complexes	complex	NOUN
eurjchem-2350	343	24	.	.	PUNCT
eurjchem-2350	344	1	acta	acta	PROPN
eurjchem-2350	344	2	crystallogr	crystallogr	PROPN
eurjchem-2350	344	3	.	.	PUNCT
eurjchem-2350	345	1	d	d	X
eurjchem-2350	345	2	biol	biol	PROPN
eurjchem-2350	345	3	.	.	PUNCT
eurjchem-2350	346	1	crystallogr	crystallogr	PROPN
eurjchem-2350	346	2	.	.	PUNCT
eurjchem-2350	347	1	2004	2004	NUM
eurjchem-2350	347	2	,	,	PUNCT
eurjchem-2350	347	3	60	60	NUM
eurjchem-2350	347	4	(	(	PUNCT
eurjchem-2350	347	5	pt	pt	X
eurjchem-2350	347	6	8)	8)	NUM
eurjchem-2350	347	7	,	,	PUNCT
eurjchem-2350	347	8	1355–1363	1355–1363	NUM
eurjchem-2350	347	9	.	.	PUNCT
eurjchem-2350	348	1	[	[	X
eurjchem-2350	348	2	33	33	NUM
eurjchem-2350	348	3	]	]	SYM
eurjchem-2350	348	4	.	.	PUNCT
eurjchem-2350	348	5	sastry	sastry	PROPN
eurjchem-2350	348	6	,	,	PUNCT
eurjchem-2350	348	7	g.	g.	PROPN
eurjchem-2350	348	8	m.	m.	PROPN
eurjchem-2350	348	9	;	;	PUNCT
eurjchem-2350	348	10	adzhigirey	adzhigirey	PROPN
eurjchem-2350	348	11	,	,	PUNCT
eurjchem-2350	348	12	m.	m.	NOUN
eurjchem-2350	348	13	;	;	PUNCT
eurjchem-2350	348	14	day	day	NOUN
eurjchem-2350	348	15	,	,	PUNCT
eurjchem-2350	348	16	t.	t.	PROPN
eurjchem-2350	348	17	;	;	PUNCT
eurjchem-2350	348	18	annabhimoju	annabhimoju	PROPN
eurjchem-2350	348	19	,	,	PUNCT
eurjchem-2350	348	20	r.	r.	PROPN
eurjchem-2350	348	21	;	;	PUNCT
eurjchem-2350	348	22	sherman	sherman	PROPN
eurjchem-2350	348	23	,	,	PUNCT
eurjchem-2350	348	24	w.	w.	NOUN
eurjchem-2350	348	25	protein	protein	NOUN
eurjchem-2350	348	26	and	and	CCONJ
eurjchem-2350	348	27	ligand	ligand	ADJ
eurjchem-2350	348	28	preparation	preparation	NOUN
eurjchem-2350	348	29	:	:	PUNCT
eurjchem-2350	348	30	parameters	parameter	NOUN
eurjchem-2350	348	31	,	,	PUNCT
eurjchem-2350	348	32	protocols	protocol	NOUN
eurjchem-2350	348	33	,	,	PUNCT
eurjchem-2350	348	34	and	and	CCONJ
eurjchem-2350	348	35	influence	influence	NOUN
eurjchem-2350	348	36	on	on	ADP
eurjchem-2350	348	37	virtual	virtual	ADJ
eurjchem-2350	348	38	screening	screening	NOUN
eurjchem-2350	348	39	enrichments	enrichment	NOUN
eurjchem-2350	348	40	.	.	PUNCT
eurjchem-2350	349	1	j.	j.	PROPN
eurjchem-2350	349	2	comput	comput	PROPN
eurjchem-2350	349	3	.	.	PUNCT
eurjchem-2350	349	4	aided	aid	VERB
eurjchem-2350	349	5	mol	mol	PROPN
eurjchem-2350	349	6	.	.	PUNCT
eurjchem-2350	350	1	des	des	PROPN
eurjchem-2350	350	2	.	.	PROPN
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eurjchem-2350	350	4	,	,	PUNCT
eurjchem-2350	350	5	27	27	NUM
eurjchem-2350	350	6	(	(	PUNCT
eurjchem-2350	350	7	3	3	NUM
eurjchem-2350	350	8	)	)	PUNCT
eurjchem-2350	350	9	,	,	PUNCT
eurjchem-2350	350	10	221–234	221–234	NUM
eurjchem-2350	350	11	.	.	PUNCT
eurjchem-2350	351	1	[	[	X
eurjchem-2350	351	2	34	34	NUM
eurjchem-2350	351	3	]	]	PUNCT
eurjchem-2350	351	4	.	.	PUNCT
eurjchem-2350	352	1	jin	jin	PROPN
eurjchem-2350	352	2	,	,	PUNCT
eurjchem-2350	352	3	z.	z.	PROPN
eurjchem-2350	352	4	;	;	PUNCT
eurjchem-2350	352	5	du	du	PROPN
eurjchem-2350	352	6	,	,	PUNCT
eurjchem-2350	352	7	x.	x.	PROPN
eurjchem-2350	352	8	;	;	PUNCT
eurjchem-2350	352	9	xu	xu	INTJ
eurjchem-2350	352	10	,	,	PUNCT
eurjchem-2350	352	11	y.	y.	PROPN
eurjchem-2350	352	12	;	;	PUNCT
eurjchem-2350	352	13	deng	deng	PROPN
eurjchem-2350	352	14	,	,	PUNCT
eurjchem-2350	352	15	y.	y.	PROPN
eurjchem-2350	352	16	;	;	PUNCT
eurjchem-2350	352	17	liu	liu	PROPN
eurjchem-2350	352	18	,	,	PUNCT
eurjchem-2350	352	19	m.	m.	NOUN
eurjchem-2350	352	20	;	;	PUNCT
eurjchem-2350	352	21	zhao	zhao	X
eurjchem-2350	352	22	,	,	PUNCT
eurjchem-2350	352	23	y.	y.	PROPN
eurjchem-2350	352	24	;	;	PUNCT
eurjchem-2350	352	25	zhang	zhang	PROPN
eurjchem-2350	352	26	,	,	PUNCT
eurjchem-2350	352	27	b.	b.	PROPN
eurjchem-2350	352	28	;	;	PUNCT
eurjchem-2350	352	29	li	li	PROPN
eurjchem-2350	352	30	,	,	PUNCT
eurjchem-2350	352	31	x.	x.	PROPN
eurjchem-2350	352	32	;	;	PUNCT
eurjchem-2350	352	33	zhang	zhang	PROPN
eurjchem-2350	352	34	,	,	PUNCT
eurjchem-2350	352	35	l.	l.	PROPN
eurjchem-2350	352	36	;	;	PUNCT
eurjchem-2350	352	37	peng	peng	PROPN
eurjchem-2350	352	38	,	,	PUNCT
eurjchem-2350	352	39	c.	c.	PROPN
eurjchem-2350	352	40	;	;	PUNCT
eurjchem-2350	352	41	duan	duan	PROPN
eurjchem-2350	352	42	,	,	PUNCT
eurjchem-2350	352	43	y.	y.	PROPN
eurjchem-2350	352	44	;	;	PUNCT
eurjchem-2350	352	45	yu	yu	PROPN
eurjchem-2350	352	46	,	,	PUNCT
eurjchem-2350	352	47	j.	j.	PROPN
eurjchem-2350	352	48	;	;	PUNCT
eurjchem-2350	352	49	wang	wang	PROPN
eurjchem-2350	352	50	,	,	PUNCT
eurjchem-2350	352	51	l.	l.	PROPN
eurjchem-2350	352	52	;	;	PUNCT
eurjchem-2350	352	53	yang	yang	PROPN
eurjchem-2350	352	54	,	,	PUNCT
eurjchem-2350	352	55	k.	k.	PROPN
eurjchem-2350	352	56	;	;	PUNCT
eurjchem-2350	352	57	liu	liu	PROPN
eurjchem-2350	352	58	,	,	PUNCT
eurjchem-2350	352	59	f.	f.	PROPN
eurjchem-2350	352	60	;	;	PUNCT
eurjchem-2350	352	61	jiang	jiang	PROPN
eurjchem-2350	352	62	,	,	PUNCT
eurjchem-2350	352	63	r.	r.	PROPN
eurjchem-2350	352	64	;	;	PUNCT
eurjchem-2350	352	65	yang	yang	PROPN
eurjchem-2350	352	66	,	,	PUNCT
eurjchem-2350	352	67	x.	x.	PROPN
eurjchem-2350	352	68	;	;	PUNCT
eurjchem-2350	352	69	you	you	PRON
eurjchem-2350	352	70	,	,	PUNCT
eurjchem-2350	352	71	t.	t.	PROPN
eurjchem-2350	352	72	;	;	PUNCT
eurjchem-2350	352	73	liu	liu	PROPN
eurjchem-2350	352	74	,	,	PUNCT
eurjchem-2350	352	75	x.	x.	PROPN
eurjchem-2350	352	76	;	;	PUNCT
eurjchem-2350	352	77	yang	yang	PROPN
eurjchem-2350	352	78	,	,	PUNCT
eurjchem-2350	352	79	x.	x.	PROPN
eurjchem-2350	352	80	;	;	PUNCT
eurjchem-2350	352	81	bai	bai	PROPN
eurjchem-2350	352	82	,	,	PUNCT
eurjchem-2350	352	83	f.	f.	PROPN
eurjchem-2350	352	84	;	;	PUNCT
eurjchem-2350	352	85	liu	liu	PROPN
eurjchem-2350	352	86	,	,	PUNCT
eurjchem-2350	352	87	h.	h.	PROPN
eurjchem-2350	352	88	;	;	PUNCT
eurjchem-2350	352	89	liu	liu	PROPN
eurjchem-2350	352	90	,	,	PUNCT
eurjchem-2350	352	91	x.	x.	PROPN
eurjchem-2350	352	92	;	;	PUNCT
eurjchem-2350	352	93	guddat	guddat	NOUN
eurjchem-2350	352	94	,	,	PUNCT
eurjchem-2350	352	95	l.	l.	PROPN
eurjchem-2350	352	96	w.	w.	PROPN
eurjchem-2350	352	97	;	;	PUNCT
eurjchem-2350	352	98	xu	xu	PROPN
eurjchem-2350	352	99	,	,	PUNCT
eurjchem-2350	352	100	w.	w.	PROPN
eurjchem-2350	352	101	;	;	PUNCT
eurjchem-2350	352	102	xiao	xiao	PROPN
eurjchem-2350	352	103	,	,	PUNCT
eurjchem-2350	352	104	g.	g.	PROPN
eurjchem-2350	352	105	;	;	PUNCT
eurjchem-2350	352	106	qin	qin	PROPN
eurjchem-2350	352	107	,	,	PUNCT
eurjchem-2350	352	108	c.	c.	PROPN
eurjchem-2350	352	109	;	;	PUNCT
eurjchem-2350	352	110	shi	shi	PROPN
eurjchem-2350	352	111	,	,	PUNCT
eurjchem-2350	352	112	z.	z.	PROPN
eurjchem-2350	352	113	;	;	PUNCT
eurjchem-2350	352	114	jiang	jiang	PROPN
eurjchem-2350	352	115	,	,	PUNCT
eurjchem-2350	352	116	h.	h.	PROPN
eurjchem-2350	352	117	;	;	PUNCT
eurjchem-2350	352	118	rao	rao	PROPN
eurjchem-2350	352	119	,	,	PUNCT
eurjchem-2350	352	120	z.	z.	PROPN
eurjchem-2350	352	121	;	;	PUNCT
eurjchem-2350	352	122	yang	yang	PROPN
eurjchem-2350	352	123	,	,	PUNCT
eurjchem-2350	352	124	h.	h.	PROPN
eurjchem-2350	352	125	structure	structure	NOUN
eurjchem-2350	352	126	of	of	ADP
eurjchem-2350	352	127	mpro	mpro	ADJ
eurjchem-2350	352	128	from	from	ADP
eurjchem-2350	352	129	sars	sar	NOUN
eurjchem-2350	352	130	-	-	PUNCT
eurjchem-2350	352	131	cov-2	cov-2	PART
eurjchem-2350	352	132	and	and	CCONJ
eurjchem-2350	352	133	discovery	discovery	NOUN
eurjchem-2350	352	134	of	of	ADP
eurjchem-2350	352	135	its	its	PRON
eurjchem-2350	352	136	inhibitors	inhibitor	NOUN
eurjchem-2350	352	137	.	.	PUNCT
eurjchem-2350	353	1	nature	nature	NOUN
eurjchem-2350	353	2	2020	2020	NUM
eurjchem-2350	353	3	,	,	PUNCT
eurjchem-2350	353	4	582	582	NUM
eurjchem-2350	353	5	(	(	PUNCT
eurjchem-2350	353	6	7811	7811	NUM
eurjchem-2350	353	7	)	)	PUNCT
eurjchem-2350	353	8	,	,	PUNCT
eurjchem-2350	353	9	289–293	289–293	NUM
eurjchem-2350	353	10	.	.	PUNCT
eurjchem-2350	354	1	[	[	X
eurjchem-2350	354	2	35	35	NUM
eurjchem-2350	354	3	]	]	SYM
eurjchem-2350	354	4	.	.	PUNCT
eurjchem-2350	355	1	estrada	estrada	PROPN
eurjchem-2350	355	2	,	,	PUNCT
eurjchem-2350	355	3	e.	e.	PROPN
eurjchem-2350	355	4	topological	topological	PROPN
eurjchem-2350	355	5	analysis	analysis	NOUN
eurjchem-2350	355	6	of	of	ADP
eurjchem-2350	355	7	sars	sar	NOUN
eurjchem-2350	355	8	cov-2	cov-2	PART
eurjchem-2350	355	9	main	main	ADJ
eurjchem-2350	355	10	protease	protease	NOUN
eurjchem-2350	355	11	.	.	PUNCT
eurjchem-2350	356	1	chaos	chaos	NOUN
eurjchem-2350	356	2	2020	2020	NUM
eurjchem-2350	356	3	,	,	PUNCT
eurjchem-2350	356	4	30	30	NUM
eurjchem-2350	356	5	(	(	PUNCT
eurjchem-2350	356	6	6	6	NUM
eurjchem-2350	356	7	)	)	PUNCT
eurjchem-2350	356	8	,	,	PUNCT
eurjchem-2350	356	9	061102	061102	NUM
eurjchem-2350	356	10	.	.	PUNCT
eurjchem-2350	357	1	[	[	X
eurjchem-2350	357	2	36	36	NUM
eurjchem-2350	357	3	]	]	PUNCT
eurjchem-2350	357	4	.	.	PUNCT
eurjchem-2350	358	1	zhang	zhang	PROPN
eurjchem-2350	358	2	,	,	PUNCT
eurjchem-2350	358	3	b.	b.	PROPN
eurjchem-2350	358	4	;	;	PUNCT
eurjchem-2350	358	5	zhao	zhao	PROPN
eurjchem-2350	358	6	,	,	PUNCT
eurjchem-2350	358	7	y.	y.	PROPN
eurjchem-2350	358	8	;	;	PUNCT
eurjchem-2350	358	9	jin	jin	PROPN
eurjchem-2350	358	10	,	,	PUNCT
eurjchem-2350	358	11	z.	z.	PROPN
eurjchem-2350	358	12	;	;	PUNCT
eurjchem-2350	358	13	liu	liu	PROPN
eurjchem-2350	358	14	,	,	PUNCT
eurjchem-2350	358	15	x.	x.	PROPN
eurjchem-2350	358	16	;	;	PUNCT
eurjchem-2350	358	17	yang	yang	PROPN
eurjchem-2350	358	18	,	,	PUNCT
eurjchem-2350	358	19	h.	h.	PROPN
eurjchem-2350	358	20	;	;	PUNCT
eurjchem-2350	358	21	rao	rao	PROPN
eurjchem-2350	358	22	,	,	PUNCT
eurjchem-2350	358	23	z.	z.	PROPN
eurjchem-2350	359	1	the	the	DET
eurjchem-2350	359	2	crystal	crystal	NOUN
eurjchem-2350	359	3	structure	structure	NOUN
eurjchem-2350	359	4	of	of	ADP
eurjchem-2350	359	5	covid-19	covid-19	PROPN
eurjchem-2350	359	6	main	main	ADJ
eurjchem-2350	359	7	protease	protease	NOUN
eurjchem-2350	359	8	in	in	ADP
eurjchem-2350	359	9	apo	apo	PROPN
eurjchem-2350	359	10	form	form	NOUN
eurjchem-2350	359	11	.	.	PUNCT
eurjchem-2350	360	1	worldwide	worldwide	ADJ
eurjchem-2350	360	2	protein	protein	NOUN
eurjchem-2350	360	3	data	datum	NOUN
eurjchem-2350	360	4	bank	bank	PROPN
eurjchem-2350	360	5	march	march	PROPN
eurjchem-2350	360	6	11	11	NUM
eurjchem-2350	360	7	,	,	PUNCT
eurjchem-2350	360	8	2020	2020	NUM
eurjchem-2350	360	9	.	.	PUNCT
eurjchem-2350	361	1	https://doi.org/10.2210/pdb6m03/pdb	https://doi.org/10.2210/pdb6m03/pdb	X
eurjchem-2350	361	2	.	.	PUNCT
eurjchem-2350	362	1	[	[	X
eurjchem-2350	362	2	37	37	NUM
eurjchem-2350	362	3	]	]	PUNCT
eurjchem-2350	362	4	.	.	PUNCT
eurjchem-2350	362	5	douangamath	douangamath	NOUN
eurjchem-2350	362	6	,	,	PUNCT
eurjchem-2350	362	7	a.	a.	NOUN
eurjchem-2350	362	8	;	;	PUNCT
eurjchem-2350	362	9	fearon	fearon	PROPN
eurjchem-2350	362	10	,	,	PUNCT
eurjchem-2350	362	11	d.	d.	PROPN
eurjchem-2350	362	12	;	;	PUNCT
eurjchem-2350	362	13	gehrtz	gehrtz	PROPN
eurjchem-2350	362	14	,	,	PUNCT
eurjchem-2350	362	15	p.	p.	PROPN
eurjchem-2350	362	16	;	;	PUNCT
eurjchem-2350	362	17	krojer	krojer	PROPN
eurjchem-2350	362	18	,	,	PUNCT
eurjchem-2350	362	19	t.	t.	PROPN
eurjchem-2350	362	20	;	;	PUNCT
eurjchem-2350	362	21	lukacik	lukacik	PROPN
eurjchem-2350	362	22	,	,	PUNCT
eurjchem-2350	362	23	p.	p.	PROPN
eurjchem-2350	362	24	;	;	PUNCT
eurjchem-2350	362	25	owen	owen	PROPN
eurjchem-2350	362	26	,	,	PUNCT
eurjchem-2350	362	27	c.	c.	PROPN
eurjchem-2350	362	28	d.	d.	PROPN
eurjchem-2350	362	29	;	;	PUNCT
eurjchem-2350	362	30	resnick	resnick	PROPN
eurjchem-2350	362	31	,	,	PUNCT
eurjchem-2350	362	32	e.	e.	PROPN
eurjchem-2350	362	33	;	;	PUNCT
eurjchem-2350	362	34	strain	strain	NOUN
eurjchem-2350	362	35	-	-	PUNCT
eurjchem-2350	362	36	damerell	damerell	ADJ
eurjchem-2350	362	37	,	,	PUNCT
eurjchem-2350	362	38	c.	c.	NOUN
eurjchem-2350	362	39	;	;	PUNCT
eurjchem-2350	362	40	aimon	aimon	PROPN
eurjchem-2350	362	41	,	,	PUNCT
eurjchem-2350	362	42	a.	a.	NOUN
eurjchem-2350	362	43	;	;	PUNCT
eurjchem-2350	362	44	ábrányi	ábrányi	PROPN
eurjchem-2350	362	45	-	-	PUNCT
eurjchem-2350	362	46	balogh	balogh	PROPN
eurjchem-2350	362	47	,	,	PUNCT
eurjchem-2350	362	48	p.	p.	NOUN
eurjchem-2350	362	49	;	;	PUNCT
eurjchem-2350	362	50	brandão	brandão	PROPN
eurjchem-2350	362	51	-	-	PUNCT
eurjchem-2350	362	52	neto	neto	VERB
eurjchem-2350	362	53	,	,	PUNCT
eurjchem-2350	362	54	j.	j.	PROPN
eurjchem-2350	362	55	;	;	PUNCT
eurjchem-2350	362	56	carbery	carbery	PROPN
eurjchem-2350	362	57	,	,	PUNCT
eurjchem-2350	362	58	a.	a.	NOUN
eurjchem-2350	362	59	;	;	PUNCT
eurjchem-2350	362	60	davison	davison	PROPN
eurjchem-2350	362	61	,	,	PUNCT
eurjchem-2350	362	62	g.	g.	PROPN
eurjchem-2350	362	63	;	;	PUNCT
eurjchem-2350	362	64	dias	dias	PROPN
eurjchem-2350	362	65	,	,	PUNCT
eurjchem-2350	362	66	a.	a.	NOUN
eurjchem-2350	362	67	;	;	PUNCT
eurjchem-2350	362	68	downes	downe	NOUN
eurjchem-2350	362	69	,	,	PUNCT
eurjchem-2350	362	70	t.	t.	PROPN
eurjchem-2350	362	71	d.	d.	PROPN
eurjchem-2350	362	72	;	;	PUNCT
eurjchem-2350	362	73	dunnett	dunnett	PROPN
eurjchem-2350	362	74	,	,	PUNCT
eurjchem-2350	362	75	l.	l.	PROPN
eurjchem-2350	362	76	;	;	PUNCT
eurjchem-2350	362	77	fairhead	fairhead	NOUN
eurjchem-2350	362	78	,	,	PUNCT
eurjchem-2350	362	79	m.	m.	NOUN
eurjchem-2350	362	80	;	;	PUNCT
eurjchem-2350	362	81	firth	firth	PROPN
eurjchem-2350	362	82	,	,	PUNCT
eurjchem-2350	362	83	j.	j.	PROPN
eurjchem-2350	362	84	d.	d.	PROPN
eurjchem-2350	362	85	;	;	PUNCT
eurjchem-2350	362	86	jones	jones	PROPN
eurjchem-2350	362	87	,	,	PUNCT
eurjchem-2350	362	88	s.	s.	PROPN
eurjchem-2350	362	89	p.	p.	PROPN
eurjchem-2350	362	90	;	;	PUNCT
eurjchem-2350	362	91	keeley	keeley	PROPN
eurjchem-2350	362	92	,	,	PUNCT
eurjchem-2350	362	93	a.	a.	NOUN
eurjchem-2350	362	94	;	;	PUNCT
eurjchem-2350	362	95	keserü	keserü	PROPN
eurjchem-2350	362	96	,	,	PUNCT
eurjchem-2350	362	97	g.	g.	PROPN
eurjchem-2350	362	98	m.	m.	PROPN
eurjchem-2350	362	99	;	;	PUNCT
eurjchem-2350	362	100	klein	klein	PROPN
eurjchem-2350	362	101	,	,	PUNCT
eurjchem-2350	362	102	h.	h.	PROPN
eurjchem-2350	362	103	f.	f.	PROPN
eurjchem-2350	362	104	;	;	PUNCT
eurjchem-2350	362	105	martin	martin	PROPN
eurjchem-2350	362	106	,	,	PUNCT
eurjchem-2350	362	107	m.	m.	NOUN
eurjchem-2350	362	108	p.	p.	NOUN
eurjchem-2350	362	109	;	;	PUNCT
eurjchem-2350	362	110	noble	noble	ADJ
eurjchem-2350	362	111	,	,	PUNCT
eurjchem-2350	362	112	m.	m.	NOUN
eurjchem-2350	362	113	e.	e.	PROPN
eurjchem-2350	362	114	m.	m.	PROPN
eurjchem-2350	362	115	;	;	PUNCT
eurjchem-2350	362	116	o’brien	o’brien	PROPN
eurjchem-2350	362	117	,	,	PUNCT
eurjchem-2350	362	118	p.	p.	NOUN
eurjchem-2350	362	119	;	;	PUNCT
eurjchem-2350	362	120	powell	powell	PROPN
eurjchem-2350	362	121	,	,	PUNCT
eurjchem-2350	362	122	a.	a.	NOUN
eurjchem-2350	362	123	;	;	PUNCT
eurjchem-2350	362	124	reddi	reddi	PROPN
eurjchem-2350	362	125	,	,	PUNCT
eurjchem-2350	362	126	r.	r.	PROPN
eurjchem-2350	362	127	n.	n.	PROPN
eurjchem-2350	362	128	;	;	PUNCT
eurjchem-2350	362	129	skyner	skyner	PROPN
eurjchem-2350	362	130	,	,	PUNCT
eurjchem-2350	362	131	r.	r.	PROPN
eurjchem-2350	362	132	;	;	PUNCT
eurjchem-2350	362	133	snee	snee	PROPN
eurjchem-2350	362	134	,	,	PUNCT
eurjchem-2350	362	135	m.	m.	NOUN
eurjchem-2350	362	136	;	;	PUNCT
eurjchem-2350	362	137	waring	waring	NOUN
eurjchem-2350	362	138	,	,	PUNCT
eurjchem-2350	362	139	m.	m.	NOUN
eurjchem-2350	362	140	j.	j.	PROPN
eurjchem-2350	362	141	;	;	PUNCT
eurjchem-2350	362	142	wild	wild	PROPN
eurjchem-2350	362	143	,	,	PUNCT
eurjchem-2350	362	144	c.	c.	PROPN
eurjchem-2350	362	145	;	;	PUNCT
eurjchem-2350	362	146	london	london	PROPN
eurjchem-2350	362	147	,	,	PUNCT
eurjchem-2350	362	148	n.	n.	PROPN
eurjchem-2350	362	149	;	;	PUNCT
eurjchem-2350	362	150	von	von	PROPN
eurjchem-2350	362	151	delft	delft	PROPN
eurjchem-2350	362	152	,	,	PUNCT
eurjchem-2350	362	153	f.	f.	PROPN
eurjchem-2350	362	154	;	;	PUNCT
eurjchem-2350	362	155	walsh	walsh	NOUN
eurjchem-2350	362	156	,	,	PUNCT
eurjchem-2350	362	157	m.	m.	NOUN
eurjchem-2350	362	158	a.	a.	NOUN
eurjchem-2350	362	159	crystallographic	crystallographic	ADJ
eurjchem-2350	362	160	and	and	CCONJ
eurjchem-2350	362	161	electrophilic	electrophilic	ADJ
eurjchem-2350	362	162	fragment	fragment	NOUN
eurjchem-2350	362	163	screening	screening	NOUN
eurjchem-2350	362	164	of	of	ADP
eurjchem-2350	362	165	the	the	DET
eurjchem-2350	362	166	sars	sar	NOUN
eurjchem-2350	362	167	-	-	PUNCT
eurjchem-2350	362	168	cov-2	cov-2	NOUN
eurjchem-2350	362	169	main	main	ADJ
eurjchem-2350	362	170	protease	protease	NOUN
eurjchem-2350	362	171	.	.	PUNCT
eurjchem-2350	363	1	nat	nat	PROPN
eurjchem-2350	363	2	.	.	PUNCT
eurjchem-2350	364	1	commun	commun	PROPN
eurjchem-2350	364	2	.	.	PUNCT
eurjchem-2350	365	1	2020	2020	NUM
eurjchem-2350	365	2	,	,	PUNCT
eurjchem-2350	365	3	11	11	NUM
eurjchem-2350	365	4	(	(	PUNCT
eurjchem-2350	365	5	1	1	NUM
eurjchem-2350	365	6	)	)	PUNCT
eurjchem-2350	365	7	,	,	PUNCT
eurjchem-2350	365	8	5047	5047	NUM
eurjchem-2350	365	9	.	.	PUNCT
eurjchem-2350	366	1	[	[	X
eurjchem-2350	366	2	38	38	NUM
eurjchem-2350	366	3	]	]	PUNCT
eurjchem-2350	366	4	.	.	PUNCT
eurjchem-2350	367	1	owen	owen	PROPN
eurjchem-2350	367	2	,	,	PUNCT
eurjchem-2350	367	3	c.	c.	PROPN
eurjchem-2350	367	4	d.	d.	PROPN
eurjchem-2350	367	5	;	;	PUNCT
eurjchem-2350	367	6	lukacik	lukacik	PROPN
eurjchem-2350	367	7	,	,	PUNCT
eurjchem-2350	367	8	p.	p.	NOUN
eurjchem-2350	367	9	;	;	PUNCT
eurjchem-2350	367	10	strain	strain	NOUN
eurjchem-2350	367	11	-	-	PUNCT
eurjchem-2350	367	12	damerell	damerell	ADJ
eurjchem-2350	367	13	,	,	PUNCT
eurjchem-2350	367	14	c.	c.	NOUN
eurjchem-2350	367	15	m.	m.	NOUN
eurjchem-2350	367	16	;	;	PUNCT
eurjchem-2350	367	17	douangamath	douangamath	NOUN
eurjchem-2350	367	18	,	,	PUNCT
eurjchem-2350	367	19	a.	a.	NOUN
eurjchem-2350	367	20	;	;	PUNCT
eurjchem-2350	367	21	powell	powell	PROPN
eurjchem-2350	367	22	,	,	PUNCT
eurjchem-2350	367	23	a.	a.	PROPN
eurjchem-2350	367	24	j.	j.	PROPN
eurjchem-2350	367	25	;	;	PUNCT
eurjchem-2350	367	26	fearon	fearon	PROPN
eurjchem-2350	367	27	,	,	PUNCT
eurjchem-2350	367	28	d.	d.	PROPN
eurjchem-2350	367	29	;	;	PUNCT
eurjchem-2350	367	30	brandao	brandao	PROPN
eurjchem-2350	367	31	-	-	PUNCT
eurjchem-2350	367	32	neto	neto	NOUN
eurjchem-2350	367	33	,	,	PUNCT
eurjchem-2350	367	34	j.	j.	PROPN
eurjchem-2350	367	35	;	;	PUNCT
eurjchem-2350	367	36	crawshaw	crawshaw	NOUN
eurjchem-2350	367	37	,	,	PUNCT
eurjchem-2350	367	38	a.	a.	PROPN
eurjchem-2350	367	39	d.	d.	PROPN
eurjchem-2350	367	40	;	;	PUNCT
eurjchem-2350	367	41	aragao	aragao	ADV
eurjchem-2350	367	42	,	,	PUNCT
eurjchem-2350	367	43	d.	d.	PROPN
eurjchem-2350	367	44	;	;	PUNCT
eurjchem-2350	367	45	williams	williams	PROPN
eurjchem-2350	367	46	,	,	PUNCT
eurjchem-2350	367	47	m.	m.	NOUN
eurjchem-2350	367	48	;	;	PUNCT
eurjchem-2350	367	49	flaig	flaig	PROPN
eurjchem-2350	367	50	,	,	PUNCT
eurjchem-2350	367	51	r.	r.	PROPN
eurjchem-2350	367	52	;	;	PUNCT
eurjchem-2350	367	53	hall	hall	PROPN
eurjchem-2350	367	54	,	,	PUNCT
eurjchem-2350	367	55	d.	d.	PROPN
eurjchem-2350	367	56	r.	r.	PROPN
eurjchem-2350	367	57	;	;	PUNCT
eurjchem-2350	367	58	mcauley	mcauley	PROPN
eurjchem-2350	367	59	,	,	PUNCT
eurjchem-2350	367	60	k.	k.	PROPN
eurjchem-2350	367	61	e.	e.	PROPN
eurjchem-2350	367	62	;	;	PUNCT
eurjchem-2350	367	63	mazzorana	mazzorana	PROPN
eurjchem-2350	367	64	,	,	PUNCT
eurjchem-2350	367	65	m.	m.	NOUN
eurjchem-2350	367	66	;	;	PUNCT
eurjchem-2350	367	67	stuart	stuart	PROPN
eurjchem-2350	367	68	,	,	PUNCT
eurjchem-2350	367	69	d.	d.	PROPN
eurjchem-2350	367	70	i.	i.	PROPN
eurjchem-2350	367	71	;	;	PUNCT
eurjchem-2350	367	72	von	von	PROPN
eurjchem-2350	367	73	delft	delft	PROPN
eurjchem-2350	367	74	,	,	PUNCT
eurjchem-2350	367	75	f.	f.	PROPN
eurjchem-2350	367	76	;	;	PUNCT
eurjchem-2350	367	77	walsh	walsh	NOUN
eurjchem-2350	367	78	,	,	PUNCT
eurjchem-2350	367	79	m.	m.	NOUN
eurjchem-2350	367	80	a.	a.	PROPN
eurjchem-2350	367	81	sars	sars	PROPN
eurjchem-2350	367	82	-	-	PUNCT
eurjchem-2350	367	83	cov-2	cov-2	NOUN
eurjchem-2350	367	84	main	main	ADJ
eurjchem-2350	367	85	protease	protease	NOUN
eurjchem-2350	367	86	with	with	ADP
eurjchem-2350	367	87	unliganded	unligande	VERB
eurjchem-2350	367	88	active	active	ADJ
eurjchem-2350	367	89	site	site	NOUN
eurjchem-2350	367	90	(	(	PUNCT
eurjchem-2350	367	91	2019	2019	NUM
eurjchem-2350	367	92	-	-	PUNCT
eurjchem-2350	367	93	ncov	ncov	NOUN
eurjchem-2350	367	94	,	,	PUNCT
eurjchem-2350	367	95	coronavirus	coronavirus	NOUN
eurjchem-2350	367	96	disease	disease	NOUN
eurjchem-2350	367	97	2019	2019	NUM
eurjchem-2350	367	98	,	,	PUNCT
eurjchem-2350	367	99	covid-19	covid-19	PROPN
eurjchem-2350	367	100	)	)	PUNCT
eurjchem-2350	367	101	.	.	PUNCT
eurjchem-2350	368	1	worldwide	worldwide	ADV
eurjchem-2350	368	2	protein	protein	NOUN
eurjchem-2350	368	3	data	datum	NOUN
eurjchem-2350	368	4	bank	bank	PROPN
eurjchem-2350	368	5	march	march	PROPN
eurjchem-2350	368	6	11	11	NUM
eurjchem-2350	368	7	,	,	PUNCT
eurjchem-2350	368	8	2020	2020	NUM
eurjchem-2350	368	9	.	.	PUNCT
eurjchem-2350	369	1	https://doi.org/10.2210/pdb6y84/pdb	https://doi.org/10.2210/pdb6y84/pdb	X
eurjchem-2350	369	2	.	.	PUNCT
eurjchem-2350	370	1	[	[	X
eurjchem-2350	370	2	39	39	NUM
eurjchem-2350	370	3	]	]	PUNCT
eurjchem-2350	370	4	.	.	PUNCT
eurjchem-2350	371	1	pandey	pandey	PROPN
eurjchem-2350	371	2	,	,	PUNCT
eurjchem-2350	371	3	a.	a.	PROPN
eurjchem-2350	371	4	k.	k.	PROPN
eurjchem-2350	371	5	;	;	PUNCT
eurjchem-2350	371	6	siddiqui	siddiqui	NOUN
eurjchem-2350	371	7	,	,	PUNCT
eurjchem-2350	371	8	m.	m.	PROPN
eurjchem-2350	371	9	h.	h.	PROPN
eurjchem-2350	371	10	;	;	PUNCT
eurjchem-2350	371	11	dutta	dutta	PROPN
eurjchem-2350	371	12	,	,	PUNCT
eurjchem-2350	371	13	r.	r.	PROPN
eurjchem-2350	371	14	drug	drug	NOUN
eurjchem-2350	371	15	-	-	PUNCT
eurjchem-2350	371	16	likeness	likeness	NOUN
eurjchem-2350	371	17	prediction	prediction	NOUN
eurjchem-2350	371	18	of	of	ADP
eurjchem-2350	371	19	designed	design	VERB
eurjchem-2350	371	20	analogues	analogue	NOUN
eurjchem-2350	371	21	of	of	ADP
eurjchem-2350	371	22	isoniazid	isoniazid	PROPN
eurjchem-2350	371	23	standard	standard	ADJ
eurjchem-2350	371	24	targeting	target	VERB
eurjchem-2350	371	25	fabi	fabi	NOUN
eurjchem-2350	371	26	enzyme	enzyme	NOUN
eurjchem-2350	371	27	regulation	regulation	NOUN
eurjchem-2350	371	28	from	from	ADP
eurjchem-2350	371	29	p.	p.	NOUN
eurjchem-2350	371	30	falciparum	falciparum	PROPN
eurjchem-2350	371	31	.	.	PUNCT
eurjchem-2350	372	1	bioinformation	bioinformation	NOUN
eurjchem-2350	372	2	2019	2019	NUM
eurjchem-2350	372	3	,	,	PUNCT
eurjchem-2350	372	4	15	15	NUM
eurjchem-2350	372	5	(	(	PUNCT
eurjchem-2350	372	6	5	5	NUM
eurjchem-2350	372	7	)	)	PUNCT
eurjchem-2350	372	8	,	,	PUNCT
eurjchem-2350	372	9	364–368	364–368	NUM
eurjchem-2350	372	10	.	.	PUNCT
eurjchem-2350	373	1	[	[	X
eurjchem-2350	373	2	40	40	NUM
eurjchem-2350	373	3	]	]	PUNCT
eurjchem-2350	373	4	.	.	PUNCT
eurjchem-2350	374	1	thakur	thakur	PROPN
eurjchem-2350	374	2	,	,	PUNCT
eurjchem-2350	374	3	z.	z.	PROPN
eurjchem-2350	374	4	;	;	PUNCT
eurjchem-2350	374	5	dharra	dharra	PROPN
eurjchem-2350	374	6	,	,	PUNCT
eurjchem-2350	374	7	r.	r.	PROPN
eurjchem-2350	374	8	;	;	PUNCT
eurjchem-2350	374	9	saini	saini	PROPN
eurjchem-2350	374	10	,	,	PUNCT
eurjchem-2350	374	11	v.	v.	PROPN
eurjchem-2350	374	12	;	;	PUNCT
eurjchem-2350	374	13	kumar	kumar	PROPN
eurjchem-2350	374	14	,	,	PUNCT
eurjchem-2350	374	15	a.	a.	PROPN
eurjchem-2350	374	16	;	;	PUNCT
eurjchem-2350	374	17	mehta	mehta	PROPN
eurjchem-2350	374	18	,	,	PUNCT
eurjchem-2350	374	19	p.	p.	PROPN
eurjchem-2350	374	20	k.	k.	PROPN
eurjchem-2350	375	1	insights	insight	NOUN
eurjchem-2350	375	2	from	from	ADP
eurjchem-2350	375	3	the	the	DET
eurjchem-2350	375	4	protein	protein	NOUN
eurjchem-2350	375	5	-	-	PUNCT
eurjchem-2350	375	6	protein	protein	NOUN
eurjchem-2350	375	7	interaction	interaction	NOUN
eurjchem-2350	375	8	network	network	NOUN
eurjchem-2350	375	9	analysis	analysis	NOUN
eurjchem-2350	375	10	of	of	ADP
eurjchem-2350	375	11	mycobacterium	mycobacterium	NOUN
eurjchem-2350	375	12	tuberculosis	tuberculosis	NOUN
eurjchem-2350	375	13	toxin	toxin	NOUN
eurjchem-2350	375	14	-	-	PUNCT
eurjchem-2350	375	15	antitoxin	antitoxin	NOUN
eurjchem-2350	375	16	systems	system	NOUN
eurjchem-2350	375	17	.	.	PUNCT
eurjchem-2350	376	1	bioinformation	bioinformation	NOUN
eurjchem-2350	376	2	2017	2017	NUM
eurjchem-2350	376	3	,	,	PUNCT
eurjchem-2350	376	4	13	13	NUM
eurjchem-2350	376	5	(	(	PUNCT
eurjchem-2350	376	6	11	11	NUM
eurjchem-2350	376	7	)	)	PUNCT
eurjchem-2350	376	8	,	,	PUNCT
eurjchem-2350	376	9	380–387	380–387	NUM
eurjchem-2350	376	10	.	.	PUNCT
eurjchem-2350	377	1	[	[	X
eurjchem-2350	377	2	41	41	NUM
eurjchem-2350	377	3	]	]	PUNCT
eurjchem-2350	377	4	.	.	PUNCT
eurjchem-2350	378	1	goddard	goddard	PROPN
eurjchem-2350	378	2	,	,	PUNCT
eurjchem-2350	378	3	t.	t.	PROPN
eurjchem-2350	378	4	d.	d.	PROPN
eurjchem-2350	378	5	;	;	PUNCT
eurjchem-2350	378	6	huang	huang	PROPN
eurjchem-2350	378	7	,	,	PUNCT
eurjchem-2350	378	8	c.	c.	PROPN
eurjchem-2350	378	9	c.	c.	PROPN
eurjchem-2350	378	10	;	;	PUNCT
eurjchem-2350	378	11	ferrin	ferrin	NOUN
eurjchem-2350	378	12	,	,	PUNCT
eurjchem-2350	378	13	t.	t.	PROPN
eurjchem-2350	378	14	e.	e.	PROPN
eurjchem-2350	378	15	visualizing	visualize	VERB
eurjchem-2350	378	16	density	density	NOUN
eurjchem-2350	378	17	maps	map	NOUN
eurjchem-2350	378	18	with	with	ADP
eurjchem-2350	378	19	ucsf	ucsf	PROPN
eurjchem-2350	378	20	chimera	chimera	PROPN
eurjchem-2350	378	21	.	.	PUNCT
eurjchem-2350	379	1	j.	j.	PROPN
eurjchem-2350	379	2	struct	struct	PROPN
eurjchem-2350	379	3	.	.	PUNCT
eurjchem-2350	380	1	biol	biol	PROPN
eurjchem-2350	380	2	.	.	PUNCT
eurjchem-2350	381	1	2007	2007	NUM
eurjchem-2350	381	2	,	,	PUNCT
eurjchem-2350	381	3	157	157	NUM
eurjchem-2350	381	4	(	(	PUNCT
eurjchem-2350	381	5	1	1	NUM
eurjchem-2350	381	6	)	)	PUNCT
eurjchem-2350	381	7	,	,	PUNCT
eurjchem-2350	381	8	281–287	281–287	NUM
eurjchem-2350	381	9	.	.	PUNCT
eurjchem-2350	382	1	[	[	X
eurjchem-2350	382	2	42	42	NUM
eurjchem-2350	382	3	]	]	PUNCT
eurjchem-2350	382	4	.	.	PUNCT
eurjchem-2350	383	1	norgan	norgan	NOUN
eurjchem-2350	383	2	,	,	PUNCT
eurjchem-2350	383	3	a.	a.	NOUN
eurjchem-2350	383	4	p.	p.	NOUN
eurjchem-2350	383	5	;	;	PUNCT
eurjchem-2350	384	1	coffman	coffman	PROPN
eurjchem-2350	384	2	,	,	PUNCT
eurjchem-2350	384	3	p.	p.	PROPN
eurjchem-2350	384	4	k.	k.	PROPN
eurjchem-2350	384	5	;	;	PUNCT
eurjchem-2350	384	6	kocher	kocher	PROPN
eurjchem-2350	384	7	,	,	PUNCT
eurjchem-2350	384	8	j.-p	j.-p	PROPN
eurjchem-2350	384	9	.	.	PUNCT
eurjchem-2350	385	1	a.	a.	NOUN
eurjchem-2350	385	2	;	;	PUNCT
eurjchem-2350	385	3	katzmann	katzmann	PROPN
eurjchem-2350	385	4	,	,	PUNCT
eurjchem-2350	385	5	d.	d.	PROPN
eurjchem-2350	385	6	j.	j.	PROPN
eurjchem-2350	385	7	;	;	PUNCT
eurjchem-2350	385	8	sosa	sosa	PROPN
eurjchem-2350	385	9	,	,	PUNCT
eurjchem-2350	385	10	c.	c.	PROPN
eurjchem-2350	385	11	p.	p.	PROPN
eurjchem-2350	385	12	multilevel	multilevel	PROPN
eurjchem-2350	385	13	parallelization	parallelization	NOUN
eurjchem-2350	385	14	of	of	ADP
eurjchem-2350	385	15	autodock	autodock	NOUN
eurjchem-2350	385	16	4.2	4.2	NUM
eurjchem-2350	385	17	.	.	PUNCT
eurjchem-2350	386	1	j.	j.	PROPN
eurjchem-2350	386	2	cheminform	cheminform	PROPN
eurjchem-2350	386	3	.	.	PUNCT
eurjchem-2350	387	1	2011	2011	NUM
eurjchem-2350	387	2	,	,	PUNCT
eurjchem-2350	387	3	3	3	NUM
eurjchem-2350	387	4	(	(	PUNCT
eurjchem-2350	387	5	1	1	NUM
eurjchem-2350	387	6	)	)	PUNCT
eurjchem-2350	387	7	,	,	PUNCT
eurjchem-2350	387	8	12	12	NUM
eurjchem-2350	387	9	.	.	PUNCT
eurjchem-2350	388	1	[	[	X
eurjchem-2350	388	2	43	43	NUM
eurjchem-2350	388	3	]	]	PUNCT
eurjchem-2350	388	4	.	.	PUNCT
eurjchem-2350	388	5	ray	ray	PROPN
eurjchem-2350	388	6	,	,	PUNCT
eurjchem-2350	388	7	s.	s.	PROPN
eurjchem-2350	388	8	;	;	PUNCT
eurjchem-2350	388	9	madrid	madrid	PROPN
eurjchem-2350	388	10	,	,	PUNCT
eurjchem-2350	388	11	p.	p.	PROPN
eurjchem-2350	388	12	b.	b.	PROPN
eurjchem-2350	388	13	;	;	PUNCT
eurjchem-2350	388	14	catz	catz	PROPN
eurjchem-2350	388	15	,	,	PUNCT
eurjchem-2350	388	16	p.	p.	NOUN
eurjchem-2350	388	17	;	;	PUNCT
eurjchem-2350	388	18	levalley	levalley	PROPN
eurjchem-2350	388	19	,	,	PUNCT
eurjchem-2350	388	20	s.	s.	PROPN
eurjchem-2350	388	21	e.	e.	PROPN
eurjchem-2350	388	22	;	;	PUNCT
eurjchem-2350	388	23	furniss	furniss	ADJ
eurjchem-2350	388	24	,	,	PUNCT
eurjchem-2350	388	25	m.	m.	NOUN
eurjchem-2350	388	26	j.	j.	PROPN
eurjchem-2350	388	27	;	;	PUNCT
eurjchem-2350	388	28	rausch	rausch	PROPN
eurjchem-2350	388	29	,	,	PUNCT
eurjchem-2350	388	30	l.	l.	PROPN
eurjchem-2350	388	31	l.	l.	PROPN
eurjchem-2350	388	32	;	;	PUNCT
eurjchem-2350	388	33	guy	guy	NOUN
eurjchem-2350	388	34	,	,	PUNCT
eurjchem-2350	388	35	r.	r.	PROPN
eurjchem-2350	388	36	k.	k.	PROPN
eurjchem-2350	388	37	;	;	PUNCT
eurjchem-2350	388	38	derisi	derisi	VERB
eurjchem-2350	388	39	,	,	PUNCT
eurjchem-2350	388	40	j.	j.	PROPN
eurjchem-2350	388	41	l.	l.	PROPN
eurjchem-2350	388	42	;	;	PUNCT
eurjchem-2350	388	43	iyer	iyer	PROPN
eurjchem-2350	388	44	,	,	PUNCT
eurjchem-2350	388	45	l.	l.	PROPN
eurjchem-2350	389	1	v.	v.	PROPN
eurjchem-2350	389	2	;	;	PUNCT
eurjchem-2350	389	3	green	green	ADJ
eurjchem-2350	389	4	,	,	PUNCT
eurjchem-2350	389	5	c.	c.	PROPN
eurjchem-2350	389	6	e.	e.	PROPN
eurjchem-2350	389	7	;	;	PUNCT
eurjchem-2350	389	8	mirsalis	mirsalis	PROPN
eurjchem-2350	389	9	,	,	PUNCT
eurjchem-2350	389	10	j.	j.	PROPN
eurjchem-2350	389	11	c.	c.	PROPN
eurjchem-2350	389	12	development	development	PROPN
eurjchem-2350	389	13	of	of	ADP
eurjchem-2350	389	14	a	a	DET
eurjchem-2350	389	15	new	new	ADJ
eurjchem-2350	389	16	generation	generation	NOUN
eurjchem-2350	389	17	of	of	ADP
eurjchem-2350	389	18	4	4	NUM
eurjchem-2350	389	19	-	-	PUNCT
eurjchem-2350	389	20	aminoquinoline	aminoquinoline	ADJ
eurjchem-2350	389	21	antimalarial	antimalarial	ADJ
eurjchem-2350	389	22	compounds	compound	NOUN
eurjchem-2350	389	23	using	use	VERB
eurjchem-2350	389	24	predictive	predictive	ADJ
eurjchem-2350	389	25	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-2350	389	26	and	and	CCONJ
eurjchem-2350	389	27	toxicology	toxicology	NOUN
eurjchem-2350	389	28	models	model	NOUN
eurjchem-2350	389	29	.	.	PUNCT
eurjchem-2350	390	1	j.	j.	PROPN
eurjchem-2350	390	2	med	med	PROPN
eurjchem-2350	390	3	.	.	PROPN
eurjchem-2350	390	4	chem	chem	PROPN
eurjchem-2350	390	5	.	.	PUNCT
eurjchem-2350	391	1	2010	2010	NUM
eurjchem-2350	391	2	,	,	PUNCT
eurjchem-2350	391	3	53	53	NUM
eurjchem-2350	391	4	(	(	PUNCT
eurjchem-2350	391	5	9	9	NUM
eurjchem-2350	391	6	)	)	PUNCT
eurjchem-2350	391	7	,	,	PUNCT
eurjchem-2350	391	8	3685–3695	3685–3695	NUM
eurjchem-2350	391	9	.	.	PUNCT
eurjchem-2350	392	1	[	[	X
eurjchem-2350	392	2	44	44	NUM
eurjchem-2350	392	3	]	]	PUNCT
eurjchem-2350	392	4	.	.	PUNCT
eurjchem-2350	392	5	balasubramaniyan	balasubramaniyan	PROPN
eurjchem-2350	392	6	,	,	PUNCT
eurjchem-2350	392	7	s.	s.	PROPN
eurjchem-2350	392	8	;	;	PUNCT
eurjchem-2350	392	9	irfan	irfan	PROPN
eurjchem-2350	392	10	,	,	PUNCT
eurjchem-2350	392	11	n.	n.	PROPN
eurjchem-2350	392	12	;	;	PUNCT
eurjchem-2350	392	13	umamaheswari	umamaheswari	ADJ
eurjchem-2350	392	14	,	,	PUNCT
eurjchem-2350	392	15	a.	a.	NOUN
eurjchem-2350	392	16	;	;	PUNCT
eurjchem-2350	392	17	puratchikody	puratchikody	NOUN
eurjchem-2350	392	18	,	,	PUNCT
eurjchem-2350	392	19	a.	a.	NOUN
eurjchem-2350	392	20	design	design	NOUN
eurjchem-2350	392	21	and	and	CCONJ
eurjchem-2350	392	22	virtual	virtual	ADJ
eurjchem-2350	392	23	screening	screening	NOUN
eurjchem-2350	392	24	of	of	ADP
eurjchem-2350	392	25	novel	novel	ADJ
eurjchem-2350	392	26	fluoroquinolone	fluoroquinolone	NOUN
eurjchem-2350	392	27	analogs	analog	NOUN
eurjchem-2350	392	28	as	as	ADP
eurjchem-2350	392	29	effective	effective	ADJ
eurjchem-2350	392	30	mutant	mutant	ADJ
eurjchem-2350	392	31	dna	dna	PROPN
eurjchem-2350	392	32	gyra	gyra	NOUN
eurjchem-2350	392	33	inhibitors	inhibitor	NOUN
eurjchem-2350	392	34	against	against	ADP
eurjchem-2350	392	35	urinary	urinary	ADJ
eurjchem-2350	392	36	tract	tract	NOUN
eurjchem-2350	392	37	infectioncausing	infectioncause	VERB
eurjchem-2350	392	38	fluoroquinolone	fluoroquinolone	NOUN
eurjchem-2350	392	39	resistant	resistant	ADJ
eurjchem-2350	392	40	escherichia	escherichia	NOUN
eurjchem-2350	392	41	coli	coli	NOUN
eurjchem-2350	392	42	.	.	PUNCT
eurjchem-2350	393	1	rsc	rsc	PROPN
eurjchem-2350	393	2	adv	adv	PROPN
eurjchem-2350	393	3	.	.	PROPN
eurjchem-2350	393	4	2018	2018	NUM
eurjchem-2350	393	5	,	,	PUNCT
eurjchem-2350	393	6	8	8	NUM
eurjchem-2350	393	7	(	(	PUNCT
eurjchem-2350	393	8	42	42	NUM
eurjchem-2350	393	9	)	)	PUNCT
eurjchem-2350	393	10	,	,	PUNCT
eurjchem-2350	393	11	23629–23647	23629–23647	NUM
eurjchem-2350	393	12	.	.	PUNCT
eurjchem-2350	394	1	[	[	X
eurjchem-2350	394	2	45	45	NUM
eurjchem-2350	394	3	]	]	PUNCT
eurjchem-2350	394	4	.	.	PUNCT
eurjchem-2350	395	1	kumar	kumar	PROPN
eurjchem-2350	395	2	,	,	PUNCT
eurjchem-2350	395	3	p.	p.	PROPN
eurjchem-2350	395	4	;	;	PUNCT
eurjchem-2350	395	5	satyanarayan	satyanarayan	ADJ
eurjchem-2350	395	6	,	,	PUNCT
eurjchem-2350	395	7	n.	n.	PROPN
eurjchem-2350	395	8	d.	d.	PROPN
eurjchem-2350	395	9	;	;	PUNCT
eurjchem-2350	395	10	madhunapantula	madhunapantula	PROPN
eurjchem-2350	395	11	,	,	PUNCT
eurjchem-2350	395	12	s.	s.	PROPN
eurjchem-2350	395	13	r.	r.	PROPN
eurjchem-2350	395	14	v.	v.	PROPN
eurjchem-2350	395	15	;	;	PUNCT
eurjchem-2350	395	16	kumar	kumar	PROPN
eurjchem-2350	395	17	,	,	PUNCT
eurjchem-2350	395	18	h.	h.	PROPN
eurjchem-2350	395	19	s.	s.	PROPN
eurjchem-2350	395	20	s.	s.	PROPN
eurjchem-2350	395	21	;	;	PUNCT
eurjchem-2350	395	22	achur	achur	NOUN
eurjchem-2350	395	23	,	,	PUNCT
eurjchem-2350	395	24	r.	r.	PROPN
eurjchem-2350	395	25	in	in	ADP
eurjchem-2350	395	26	silico	silico	NOUN
eurjchem-2350	395	27	screening	screen	VERB
eurjchem-2350	395	28	for	for	ADP
eurjchem-2350	395	29	the	the	DET
eurjchem-2350	395	30	interaction	interaction	NOUN
eurjchem-2350	395	31	of	of	ADP
eurjchem-2350	395	32	small	small	ADJ
eurjchem-2350	395	33	molecules	molecule	NOUN
eurjchem-2350	395	34	with	with	ADP
eurjchem-2350	395	35	their	their	PRON
eurjchem-2350	395	36	targets	target	NOUN
eurjchem-2350	395	37	and	and	CCONJ
eurjchem-2350	395	38	evaluation	evaluation	NOUN
eurjchem-2350	395	39	of	of	ADP
eurjchem-2350	395	40	therapeutic	therapeutic	ADJ
eurjchem-2350	395	41	efficacy	efficacy	NOUN
eurjchem-2350	395	42	by	by	ADP
eurjchem-2350	395	43	free	free	ADJ
eurjchem-2350	395	44	online	online	ADJ
eurjchem-2350	395	45	tools	tool	NOUN
eurjchem-2350	395	46	.	.	PUNCT
eurjchem-2350	396	1	eur	eur	PROPN
eurjchem-2350	396	2	.	.	PUNCT
eurjchem-2350	397	1	j.	j.	PROPN
eurjchem-2350	397	2	chem	chem	PROPN
eurjchem-2350	397	3	.	.	PUNCT
eurjchem-2350	398	1	2020	2020	NUM
eurjchem-2350	398	2	,	,	PUNCT
eurjchem-2350	398	3	11	11	NUM
eurjchem-2350	398	4	(	(	PUNCT
eurjchem-2350	398	5	2	2	NUM
eurjchem-2350	398	6	)	)	PUNCT
eurjchem-2350	398	7	,	,	PUNCT
eurjchem-2350	398	8	168–178	168–178	NUM
eurjchem-2350	398	9	.	.	PUNCT
eurjchem-2350	399	1	[	[	X
eurjchem-2350	399	2	46	46	NUM
eurjchem-2350	399	3	]	]	PUNCT
eurjchem-2350	399	4	.	.	PUNCT
eurjchem-2350	400	1	han	han	PROPN
eurjchem-2350	400	2	,	,	PUNCT
eurjchem-2350	400	3	y.	y.	PROPN
eurjchem-2350	400	4	;	;	PUNCT
eurjchem-2350	400	5	zhang	zhang	PROPN
eurjchem-2350	400	6	,	,	PUNCT
eurjchem-2350	400	7	j.	j.	PROPN
eurjchem-2350	400	8	;	;	PUNCT
eurjchem-2350	400	9	hu	hu	PROPN
eurjchem-2350	400	10	,	,	PUNCT
eurjchem-2350	400	11	c.	c.	PROPN
eurjchem-2350	400	12	q.	q.	PROPN
eurjchem-2350	400	13	;	;	PUNCT
eurjchem-2350	400	14	zhang	zhang	PROPN
eurjchem-2350	400	15	,	,	PUNCT
eurjchem-2350	400	16	x.	x.	PROPN
eurjchem-2350	400	17	;	;	PUNCT
eurjchem-2350	400	18	ma	ma	PROPN
eurjchem-2350	400	19	,	,	PUNCT
eurjchem-2350	400	20	b.	b.	PROPN
eurjchem-2350	400	21	;	;	PUNCT
eurjchem-2350	400	22	zhang	zhang	PROPN
eurjchem-2350	400	23	,	,	PUNCT
eurjchem-2350	400	24	p.	p.	NOUN
eurjchem-2350	400	25	in	in	ADP
eurjchem-2350	400	26	silico	silico	NOUN
eurjchem-2350	400	27	adme	adme	NOUN
eurjchem-2350	400	28	and	and	CCONJ
eurjchem-2350	400	29	toxicity	toxicity	NOUN
eurjchem-2350	400	30	prediction	prediction	NOUN
eurjchem-2350	400	31	of	of	ADP
eurjchem-2350	400	32	ceftazidime	ceftazidime	NOUN
eurjchem-2350	400	33	and	and	CCONJ
eurjchem-2350	400	34	its	its	PRON
eurjchem-2350	400	35	impurities	impurity	NOUN
eurjchem-2350	400	36	.	.	PUNCT
eurjchem-2350	401	1	front	front	ADJ
eurjchem-2350	401	2	.	.	PUNCT
eurjchem-2350	402	1	pharmacol	pharmacol	PROPN
eurjchem-2350	402	2	.	.	PROPN
eurjchem-2350	403	1	2019	2019	NUM
eurjchem-2350	403	2	,	,	PUNCT
eurjchem-2350	403	3	10	10	NUM
eurjchem-2350	403	4	,	,	PUNCT
eurjchem-2350	403	5	434	434	NUM
eurjchem-2350	403	6	.	.	PUNCT
eurjchem-2350	404	1	[	[	X
eurjchem-2350	404	2	47	47	NUM
eurjchem-2350	404	3	]	]	PUNCT
eurjchem-2350	404	4	.	.	PUNCT
eurjchem-2350	405	1	small	small	ADJ
eurjchem-2350	405	2	-	-	PUNCT
eurjchem-2350	405	3	molecule	molecule	NOUN
eurjchem-2350	405	4	drug	drug	NOUN
eurjchem-2350	405	5	discovery	discovery	NOUN
eurjchem-2350	405	6	suite	suite	NOUN
eurjchem-2350	405	7	2013	2013	NUM
eurjchem-2350	405	8	qikprop	qikprop	NOUN
eurjchem-2350	405	9	,	,	PUNCT
eurjchem-2350	405	10	version	version	NOUN
eurjchem-2350	405	11	3.8	3.8	NUM
eurjchem-2350	405	12	,	,	PUNCT
eurjchem-2350	405	13	schrödinger	schrödinger	NOUN
eurjchem-2350	405	14	,	,	PUNCT
eurjchem-2350	405	15	llc	llc	PROPN
eurjchem-2350	405	16	,	,	PUNCT
eurjchem-2350	405	17	new	new	PROPN
eurjchem-2350	405	18	york	york	PROPN
eurjchem-2350	405	19	,	,	PUNCT
eurjchem-2350	405	20	ny	ny	PROPN
eurjchem-2350	405	21	,	,	PUNCT
eurjchem-2350	405	22	2013	2013	NUM
eurjchem-2350	405	23	.	.	PUNCT
eurjchem-2350	406	1	[	[	X
eurjchem-2350	406	2	48	48	NUM
eurjchem-2350	406	3	]	]	PUNCT
eurjchem-2350	406	4	.	.	PUNCT
eurjchem-2350	407	1	clark	clark	PROPN
eurjchem-2350	407	2	,	,	PUNCT
eurjchem-2350	407	3	d.	d.	PROPN
eurjchem-2350	407	4	e.	e.	PROPN
eurjchem-2350	407	5	rapid	rapid	ADJ
eurjchem-2350	407	6	calculation	calculation	NOUN
eurjchem-2350	407	7	of	of	ADP
eurjchem-2350	407	8	polar	polar	ADJ
eurjchem-2350	407	9	molecular	molecular	ADJ
eurjchem-2350	407	10	surface	surface	NOUN
eurjchem-2350	407	11	area	area	NOUN
eurjchem-2350	407	12	and	and	CCONJ
eurjchem-2350	407	13	its	its	PRON
eurjchem-2350	407	14	application	application	NOUN
eurjchem-2350	407	15	to	to	ADP
eurjchem-2350	407	16	the	the	DET
eurjchem-2350	407	17	prediction	prediction	NOUN
eurjchem-2350	407	18	of	of	ADP
eurjchem-2350	407	19	transport	transport	NOUN
eurjchem-2350	407	20	phenomena	phenomenon	NOUN
eurjchem-2350	407	21	.	.	PUNCT
eurjchem-2350	408	1	1	1	X
eurjchem-2350	408	2	.	.	X
eurjchem-2350	408	3	prediction	prediction	NOUN
eurjchem-2350	408	4	of	of	ADP
eurjchem-2350	408	5	intestinal	intestinal	ADJ
eurjchem-2350	408	6	absorption	absorption	NOUN
eurjchem-2350	408	7	.	.	PUNCT
eurjchem-2350	409	1	j.	j.	PROPN
eurjchem-2350	409	2	pharm	pharm	PROPN
eurjchem-2350	409	3	.	.	PUNCT
eurjchem-2350	410	1	sci	sci	PROPN
eurjchem-2350	410	2	.	.	PROPN
eurjchem-2350	410	3	1999	1999	NUM
eurjchem-2350	410	4	,	,	PUNCT
eurjchem-2350	410	5	88	88	NUM
eurjchem-2350	410	6	(	(	PUNCT
eurjchem-2350	410	7	8)	8)	NUM
eurjchem-2350	410	8	,	,	PUNCT
eurjchem-2350	410	9	807–814	807–814	NUM
eurjchem-2350	410	10	.	.	PUNCT
eurjchem-2350	411	1	[	[	X
eurjchem-2350	411	2	49	49	NUM
eurjchem-2350	411	3	]	]	PUNCT
eurjchem-2350	411	4	.	.	PUNCT
eurjchem-2350	412	1	o’hagan	o’hagan	PROPN
eurjchem-2350	412	2	,	,	PUNCT
eurjchem-2350	412	3	s.	s.	PROPN
eurjchem-2350	412	4	;	;	PUNCT
eurjchem-2350	412	5	kell	kell	PROPN
eurjchem-2350	412	6	,	,	PUNCT
eurjchem-2350	412	7	d.	d.	PROPN
eurjchem-2350	412	8	b.	b.	PROPN
eurjchem-2350	413	1	the	the	DET
eurjchem-2350	413	2	apparent	apparent	ADJ
eurjchem-2350	413	3	permeabilities	permeability	NOUN
eurjchem-2350	413	4	of	of	ADP
eurjchem-2350	413	5	caco-2	caco-2	NUM
eurjchem-2350	413	6	cells	cell	NOUN
eurjchem-2350	413	7	to	to	ADP
eurjchem-2350	413	8	marketed	market	VERB
eurjchem-2350	413	9	drugs	drug	NOUN
eurjchem-2350	413	10	:	:	PUNCT
eurjchem-2350	413	11	magnitude	magnitude	NOUN
eurjchem-2350	413	12	,	,	PUNCT
eurjchem-2350	413	13	and	and	CCONJ
eurjchem-2350	413	14	independence	independence	NOUN
eurjchem-2350	413	15	from	from	ADP
eurjchem-2350	413	16	both	both	DET
eurjchem-2350	413	17	biophysical	biophysical	ADJ
eurjchem-2350	413	18	properties	property	NOUN
eurjchem-2350	413	19	and	and	CCONJ
eurjchem-2350	413	20	endogenite	endogenite	NOUN
eurjchem-2350	413	21	similarities	similarity	NOUN
eurjchem-2350	413	22	.	.	PUNCT
eurjchem-2350	414	1	peerj	peerj	PROPN
eurjchem-2350	414	2	2015	2015	NUM
eurjchem-2350	414	3	,	,	PUNCT
eurjchem-2350	414	4	3	3	NUM
eurjchem-2350	414	5	(	(	PUNCT
eurjchem-2350	414	6	e1405	e1405	PROPN
eurjchem-2350	414	7	)	)	PUNCT
eurjchem-2350	414	8	,	,	PUNCT
eurjchem-2350	414	9	e1405	e1405	PROPN
eurjchem-2350	414	10	.	.	PUNCT
eurjchem-2350	415	1	[	[	X
eurjchem-2350	415	2	50	50	NUM
eurjchem-2350	415	3	]	]	PUNCT
eurjchem-2350	415	4	.	.	PUNCT
eurjchem-2350	416	1	yang	yang	PROPN
eurjchem-2350	416	2	,	,	PUNCT
eurjchem-2350	416	3	h.	h.	PROPN
eurjchem-2350	416	4	;	;	PUNCT
eurjchem-2350	416	5	xie	xie	PROPN
eurjchem-2350	416	6	,	,	PUNCT
eurjchem-2350	416	7	w.	w.	PROPN
eurjchem-2350	416	8	;	;	PUNCT
eurjchem-2350	416	9	xue	xue	PROPN
eurjchem-2350	416	10	,	,	PUNCT
eurjchem-2350	416	11	x.	x.	PROPN
eurjchem-2350	416	12	;	;	PUNCT
eurjchem-2350	416	13	yang	yang	PROPN
eurjchem-2350	416	14	,	,	PUNCT
eurjchem-2350	416	15	k.	k.	PROPN
eurjchem-2350	416	16	;	;	PUNCT
eurjchem-2350	416	17	ma	ma	PROPN
eurjchem-2350	416	18	,	,	PUNCT
eurjchem-2350	416	19	j.	j.	PROPN
eurjchem-2350	416	20	;	;	PUNCT
eurjchem-2350	416	21	liang	liang	PROPN
eurjchem-2350	416	22	,	,	PUNCT
eurjchem-2350	416	23	w.	w.	PROPN
eurjchem-2350	416	24	;	;	PUNCT
eurjchem-2350	416	25	zhao	zhao	PROPN
eurjchem-2350	416	26	,	,	PUNCT
eurjchem-2350	416	27	q.	q.	PROPN
eurjchem-2350	416	28	;	;	PUNCT
eurjchem-2350	416	29	zhou	zhou	PROPN
eurjchem-2350	416	30	,	,	PUNCT
eurjchem-2350	416	31	z.	z.	PROPN
eurjchem-2350	416	32	;	;	PUNCT
eurjchem-2350	416	33	pei	pei	PROPN
eurjchem-2350	416	34	,	,	PUNCT
eurjchem-2350	416	35	d.	d.	PROPN
eurjchem-2350	416	36	;	;	PUNCT
eurjchem-2350	416	37	ziebuhr	ziebuhr	PROPN
eurjchem-2350	416	38	,	,	PUNCT
eurjchem-2350	416	39	j.	j.	PROPN
eurjchem-2350	416	40	;	;	PUNCT
eurjchem-2350	416	41	hilgenfeld	hilgenfeld	NOUN
eurjchem-2350	416	42	,	,	PUNCT
eurjchem-2350	416	43	r.	r.	PROPN
eurjchem-2350	416	44	;	;	PUNCT
eurjchem-2350	416	45	yuen	yuen	PROPN
eurjchem-2350	416	46	,	,	PUNCT
eurjchem-2350	416	47	k.	k.	PROPN
eurjchem-2350	416	48	y.	y.	PROPN
eurjchem-2350	416	49	;	;	PUNCT
eurjchem-2350	416	50	wong	wong	PROPN
eurjchem-2350	416	51	,	,	PUNCT
eurjchem-2350	416	52	l.	l.	PROPN
eurjchem-2350	416	53	;	;	PUNCT
eurjchem-2350	416	54	gao	gao	PROPN
eurjchem-2350	416	55	,	,	PUNCT
eurjchem-2350	416	56	g.	g.	PROPN
eurjchem-2350	416	57	;	;	PUNCT
eurjchem-2350	416	58	chen	chen	PROPN
eurjchem-2350	416	59	,	,	PUNCT
eurjchem-2350	416	60	s.	s.	PROPN
eurjchem-2350	416	61	;	;	PUNCT
eurjchem-2350	416	62	chen	chen	PROPN
eurjchem-2350	416	63	,	,	PUNCT
eurjchem-2350	416	64	z.	z.	PROPN
eurjchem-2350	416	65	;	;	PUNCT
eurjchem-2350	416	66	ma	ma	PROPN
eurjchem-2350	416	67	,	,	PUNCT
eurjchem-2350	416	68	d.	d.	PROPN
eurjchem-2350	416	69	;	;	PUNCT
eurjchem-2350	416	70	bartlam	bartlam	PROPN
eurjchem-2350	416	71	,	,	PUNCT
eurjchem-2350	416	72	m.	m.	NOUN
eurjchem-2350	416	73	;	;	PUNCT
eurjchem-2350	416	74	rao	rao	PROPN
eurjchem-2350	416	75	,	,	PUNCT
eurjchem-2350	416	76	z.	z.	PROPN
eurjchem-2350	416	77	design	design	PROPN
eurjchem-2350	416	78	of	of	ADP
eurjchem-2350	416	79	wide	wide	ADJ
eurjchem-2350	416	80	-	-	PUNCT
eurjchem-2350	416	81	spectrum	spectrum	NOUN
eurjchem-2350	416	82	inhibitors	inhibitor	NOUN
eurjchem-2350	416	83	targeting	target	VERB
eurjchem-2350	416	84	coronavirus	coronavirus	NOUN
eurjchem-2350	416	85	main	main	ADJ
eurjchem-2350	416	86	proteases	protease	NOUN
eurjchem-2350	416	87	.	.	PUNCT
eurjchem-2350	417	1	plos	plos	PROPN
eurjchem-2350	417	2	biol	biol	PROPN
eurjchem-2350	417	3	.	.	PUNCT
eurjchem-2350	418	1	2005	2005	NUM
eurjchem-2350	418	2	,	,	PUNCT
eurjchem-2350	418	3	3	3	NUM
eurjchem-2350	418	4	(	(	PUNCT
eurjchem-2350	418	5	10	10	NUM
eurjchem-2350	418	6	)	)	PUNCT
eurjchem-2350	418	7	,	,	PUNCT
eurjchem-2350	418	8	e324	e324	PROPN
eurjchem-2350	418	9	.	.	PUNCT
eurjchem-2350	419	1	[	[	X
eurjchem-2350	419	2	51	51	NUM
eurjchem-2350	419	3	]	]	PUNCT
eurjchem-2350	419	4	.	.	PUNCT
eurjchem-2350	420	1	thakkar	thakkar	PROPN
eurjchem-2350	420	2	,	,	PUNCT
eurjchem-2350	420	3	s.	s.	PROPN
eurjchem-2350	420	4	s.	s.	PROPN
eurjchem-2350	420	5	;	;	PUNCT
eurjchem-2350	420	6	shelat	shelat	PROPN
eurjchem-2350	420	7	,	,	PUNCT
eurjchem-2350	420	8	f.	f.	PROPN
eurjchem-2350	420	9	;	;	PUNCT
eurjchem-2350	420	10	thakor	thakor	PROPN
eurjchem-2350	420	11	,	,	PUNCT
eurjchem-2350	420	12	p.	p.	NOUN
eurjchem-2350	420	13	magical	magical	ADJ
eurjchem-2350	420	14	bullets	bullet	NOUN
eurjchem-2350	420	15	from	from	ADP
eurjchem-2350	420	16	an	an	DET
eurjchem-2350	420	17	indigenous	indigenous	ADJ
eurjchem-2350	420	18	indian	indian	ADJ
eurjchem-2350	420	19	medicinal	medicinal	ADJ
eurjchem-2350	420	20	plant	plant	NOUN
eurjchem-2350	420	21	tinosporacordifolia	tinosporacordifolia	NOUN
eurjchem-2350	420	22	:	:	PUNCT
eurjchem-2350	420	23	an	an	DET
eurjchem-2350	420	24	in	in	ADP
eurjchem-2350	420	25	silico	silico	NOUN
eurjchem-2350	420	26	approach	approach	NOUN
eurjchem-2350	420	27	for	for	ADP
eurjchem-2350	420	28	the	the	DET
eurjchem-2350	420	29	antidote	antidote	NOUN
eurjchem-2350	420	30	of	of	ADP
eurjchem-2350	420	31	sars	sar	NOUN
eurjchem-2350	420	32	-	-	PUNCT
eurjchem-2350	420	33	cov-2	cov-2	NOUN
eurjchem-2350	420	34	.	.	PUNCT
eurjchem-2350	421	1	egyptian	egyptian	PROPN
eurjchem-2350	421	2	j.	j.	PROPN
eurjchem-2350	421	3	petroleum	petroleum	PROPN
eurjchem-2350	421	4	2021	2021	NUM
eurjchem-2350	421	5	,	,	PUNCT
eurjchem-2350	421	6	30(1	30(1	NUM
eurjchem-2350	421	7	)	)	PUNCT
eurjchem-2350	421	8	,	,	PUNCT
eurjchem-2350	421	9	53–66	53–66	NUM
eurjchem-2350	421	10	.	.	PUNCT
eurjchem-2350	422	1	[	[	X
eurjchem-2350	422	2	52	52	NUM
eurjchem-2350	422	3	]	]	PUNCT
eurjchem-2350	422	4	.	.	PUNCT
eurjchem-2350	422	5	hatada	hatada	PROPN
eurjchem-2350	422	6	,	,	PUNCT
eurjchem-2350	422	7	r.	r.	PROPN
eurjchem-2350	422	8	;	;	PUNCT
eurjchem-2350	422	9	okuwaki	okuwaki	NOUN
eurjchem-2350	422	10	,	,	PUNCT
eurjchem-2350	422	11	k.	k.	PROPN
eurjchem-2350	422	12	;	;	PUNCT
eurjchem-2350	422	13	mochizuki	mochizuki	PROPN
eurjchem-2350	422	14	,	,	PUNCT
eurjchem-2350	422	15	y.	y.	PROPN
eurjchem-2350	422	16	;	;	PUNCT
eurjchem-2350	422	17	handa	handa	PROPN
eurjchem-2350	422	18	,	,	PUNCT
eurjchem-2350	422	19	y.	y.	PROPN
eurjchem-2350	422	20	;	;	PUNCT
eurjchem-2350	422	21	fukuzawa	fukuzawa	NOUN
eurjchem-2350	422	22	,	,	PUNCT
eurjchem-2350	422	23	k.	k.	PROPN
eurjchem-2350	422	24	;	;	PUNCT
eurjchem-2350	422	25	komeiji	komeiji	PROPN
eurjchem-2350	422	26	,	,	PUNCT
eurjchem-2350	422	27	y.	y.	PROPN
eurjchem-2350	422	28	;	;	PUNCT
eurjchem-2350	422	29	okiyama	okiyama	PROPN
eurjchem-2350	422	30	,	,	PUNCT
eurjchem-2350	422	31	y.	y.	PROPN
eurjchem-2350	422	32	;	;	PUNCT
eurjchem-2350	422	33	tanaka	tanaka	PROPN
eurjchem-2350	422	34	,	,	PUNCT
eurjchem-2350	422	35	s.	s.	PROPN
eurjchem-2350	422	36	fragment	fragment	PROPN
eurjchem-2350	422	37	molecular	molecular	ADJ
eurjchem-2350	422	38	orbital	orbital	ADJ
eurjchem-2350	422	39	based	base	VERB
eurjchem-2350	422	40	interaction	interaction	NOUN
eurjchem-2350	422	41	analyses	analysis	NOUN
eurjchem-2350	422	42	on	on	ADP
eurjchem-2350	422	43	covid-19	covid-19	PROPN
eurjchem-2350	422	44	main	main	ADJ
eurjchem-2350	422	45	protease	protease	NOUN
eurjchem-2350	422	46	inhibitor	inhibitor	NOUN
eurjchem-2350	422	47	n3	n3	NOUN
eurjchem-2350	422	48	complex	complex	NOUN
eurjchem-2350	422	49	(	(	PUNCT
eurjchem-2350	422	50	pdb	pdb	PROPN
eurjchem-2350	422	51	i	i	PROPN
eurjchem-2350	422	52	d	d	PROPN
eurjchem-2350	422	53	:	:	PUNCT
eurjchem-2350	422	54	6lu7	6lu7	NUM
eurjchem-2350	422	55	)	)	PUNCT
eurjchem-2350	422	56	.	.	PUNCT
eurjchem-2350	423	1	j.	j.	PROPN
eurjchem-2350	423	2	chem	chem	PROPN
eurjchem-2350	423	3	.	.	PUNCT
eurjchem-2350	424	1	inf	inf	PROPN
eurjchem-2350	424	2	.	.	PROPN
eurjchem-2350	424	3	model	model	PROPN
eurjchem-2350	424	4	.	.	PUNCT
eurjchem-2350	425	1	2020	2020	NUM
eurjchem-2350	425	2	,	,	PUNCT
eurjchem-2350	425	3	60	60	NUM
eurjchem-2350	425	4	(	(	PUNCT
eurjchem-2350	425	5	7	7	NUM
eurjchem-2350	425	6	)	)	PUNCT
eurjchem-2350	425	7	,	,	PUNCT
eurjchem-2350	425	8	3593–3602	3593–3602	NUM
eurjchem-2350	425	9	.	.	PUNCT
eurjchem-2350	426	1	[	[	X
eurjchem-2350	426	2	53	53	NUM
eurjchem-2350	426	3	]	]	PUNCT
eurjchem-2350	426	4	.	.	PUNCT
eurjchem-2350	427	1	alexpandi	alexpandi	PROPN
eurjchem-2350	427	2	,	,	PUNCT
eurjchem-2350	427	3	r.	r.	PROPN
eurjchem-2350	427	4	;	;	PUNCT
eurjchem-2350	427	5	de	de	PROPN
eurjchem-2350	427	6	mesquita	mesquita	PROPN
eurjchem-2350	427	7	,	,	PUNCT
eurjchem-2350	427	8	j.	j.	PROPN
eurjchem-2350	427	9	f.	f.	PROPN
eurjchem-2350	427	10	;	;	PUNCT
eurjchem-2350	427	11	pandian	pandian	PROPN
eurjchem-2350	427	12	,	,	PUNCT
eurjchem-2350	427	13	s.	s.	PROPN
eurjchem-2350	427	14	k.	k.	PROPN
eurjchem-2350	427	15	;	;	PUNCT
eurjchem-2350	427	16	ravi	ravi	PROPN
eurjchem-2350	427	17	,	,	PUNCT
eurjchem-2350	427	18	a.	a.	PROPN
eurjchem-2350	427	19	v.	v.	ADP
eurjchem-2350	427	20	quinolinesbased	quinolinesbase	VERB
eurjchem-2350	427	21	sars	sar	NOUN
eurjchem-2350	427	22	-	-	PUNCT
eurjchem-2350	427	23	cov-2	cov-2	NUM
eurjchem-2350	427	24	3clpro	3clpro	NUM
eurjchem-2350	427	25	and	and	CCONJ
eurjchem-2350	427	26	rdrp	rdrp	NOUN
eurjchem-2350	427	27	inhibitors	inhibitor	NOUN
eurjchem-2350	427	28	and	and	CCONJ
eurjchem-2350	427	29	spike	spike	NOUN
eurjchem-2350	427	30	-	-	PUNCT
eurjchem-2350	427	31	rbd	rbd	NOUN
eurjchem-2350	427	32	-	-	PUNCT
eurjchem-2350	427	33	ace2	ace2	NOUN
eurjchem-2350	427	34	inhibitor	inhibitor	NOUN
eurjchem-2350	427	35	for	for	ADP
eurjchem-2350	427	36	drug	drug	NOUN
eurjchem-2350	427	37	-	-	PUNCT
eurjchem-2350	427	38	repurposing	repurpose	VERB
eurjchem-2350	427	39	against	against	ADP
eurjchem-2350	427	40	covid-19	covid-19	PROPN
eurjchem-2350	427	41	:	:	PUNCT
eurjchem-2350	427	42	an	an	PRON
eurjchem-2350	427	43	in	in	ADP
eurjchem-2350	427	44	silico	silico	NOUN
eurjchem-2350	427	45	analysis	analysis	NOUN
eurjchem-2350	427	46	.	.	PUNCT
eurjchem-2350	428	1	front	front	ADJ
eurjchem-2350	428	2	.	.	PUNCT
eurjchem-2350	429	1	microbiol	microbiol	PROPN
eurjchem-2350	429	2	.	.	PUNCT
eurjchem-2350	430	1	2020	2020	NUM
eurjchem-2350	430	2	,	,	PUNCT
eurjchem-2350	430	3	11	11	NUM
eurjchem-2350	430	4	,	,	PUNCT
eurjchem-2350	430	5	1796	1796	NUM
eurjchem-2350	430	6	.	.	PUNCT
eurjchem-2350	431	1	https://doi.org/10.3390/v8120322	https://doi.org/10.3390/v8120322	PRON
eurjchem-2350	431	2	https://www.chemaxon.com/	https://www.chemaxon.com/	NOUN
eurjchem-2350	431	3	https://doi.org/10.2210/pdb6m03/pdb	https://doi.org/10.2210/pdb6m03/pdb	PRON
eurjchem-2350	431	4	https://doi.org/10.2210/pdb6y84/pdb	https://doi.org/10.2210/pdb6y84/pdb	PUNCT
eurjchem-2350	431	5	38	38	NUM
eurjchem-2350	431	6	kumar	kumar	PROPN
eurjchem-2350	431	7	et	et	PROPN
eurjchem-2350	431	8	al	al	PROPN
eurjchem-2350	431	9	.	.	PUNCT
eurjchem-2350	431	10	/	/	SYM
eurjchem-2350	431	11	european	european	PROPN
eurjchem-2350	431	12	journal	journal	PROPN
eurjchem-2350	431	13	of	of	ADP
eurjchem-2350	431	14	chemistry	chemistry	NOUN
eurjchem-2350	431	15	14	14	NUM
eurjchem-2350	431	16	(	(	PUNCT
eurjchem-2350	431	17	1	1	NUM
eurjchem-2350	431	18	)	)	PUNCT
eurjchem-2350	431	19	(	(	PUNCT
eurjchem-2350	431	20	2023	2023	NUM
eurjchem-2350	431	21	)	)	PUNCT
eurjchem-2350	431	22	30	30	NUM
eurjchem-2350	431	23	-	-	SYM
eurjchem-2350	431	24	38	38	NUM
eurjchem-2350	431	25	2023	2023	NUM
eurjchem-2350	431	26	–	–	PUNCT
eurjchem-2350	431	27	european	european	ADJ
eurjchem-2350	431	28	journal	journal	NOUN
eurjchem-2350	431	29	of	of	ADP
eurjchem-2350	431	30	chemistry	chemistry	NOUN
eurjchem-2350	431	31	–	–	PUNCT
eurjchem-2350	431	32	cc	cc	NOUN
eurjchem-2350	431	33	by	by	ADP
eurjchem-2350	431	34	nc	nc	PROPN
eurjchem-2350	431	35	–	–	PUNCT
eurjchem-2350	431	36	doi	doi	PROPN
eurjchem-2350	431	37	:	:	PUNCT
eurjchem-2350	431	38	10.5155	10.5155	NUM
eurjchem-2350	431	39	/	/	SYM
eurjchem-2350	431	40	eurjchem.14.1.30	eurjchem.14.1.30	PROPN
eurjchem-2350	431	41	-	-	PUNCT
eurjchem-2350	431	42	38.2350	38.2350	NUM
eurjchem-2350	431	43	[	[	X
eurjchem-2350	431	44	54	54	NUM
eurjchem-2350	431	45	]	]	PUNCT
eurjchem-2350	431	46	.	.	PUNCT
eurjchem-2350	432	1	zumla	zumla	NOUN
eurjchem-2350	432	2	,	,	PUNCT
eurjchem-2350	432	3	a.	a.	NOUN
eurjchem-2350	432	4	;	;	PUNCT
eurjchem-2350	432	5	chan	chan	PROPN
eurjchem-2350	432	6	,	,	PUNCT
eurjchem-2350	432	7	j.	j.	PROPN
eurjchem-2350	432	8	f.	f.	PROPN
eurjchem-2350	432	9	w.	w.	PROPN
eurjchem-2350	432	10	;	;	PUNCT
eurjchem-2350	432	11	azhar	azhar	PROPN
eurjchem-2350	432	12	,	,	PUNCT
eurjchem-2350	432	13	e.	e.	PROPN
eurjchem-2350	432	14	i.	i.	PROPN
eurjchem-2350	432	15	;	;	PUNCT
eurjchem-2350	432	16	hui	hui	PROPN
eurjchem-2350	432	17	,	,	PUNCT
eurjchem-2350	432	18	d.	d.	PROPN
eurjchem-2350	432	19	s.	s.	PROPN
eurjchem-2350	432	20	c.	c.	PROPN
eurjchem-2350	432	21	;	;	PUNCT
eurjchem-2350	432	22	yuen	yuen	PROPN
eurjchem-2350	432	23	,	,	PUNCT
eurjchem-2350	432	24	k.-y	k.-y	NOUN
eurjchem-2350	432	25	.	.	PUNCT
eurjchem-2350	433	1	coronaviruses	coronaviruse	NOUN
eurjchem-2350	433	2	drug	drug	NOUN
eurjchem-2350	433	3	discovery	discovery	NOUN
eurjchem-2350	433	4	and	and	CCONJ
eurjchem-2350	433	5	therapeutic	therapeutic	ADJ
eurjchem-2350	433	6	options	option	NOUN
eurjchem-2350	433	7	.	.	PUNCT
eurjchem-2350	434	1	nat	nat	PROPN
eurjchem-2350	434	2	.	.	PUNCT
eurjchem-2350	435	1	rev	rev	PROPN
eurjchem-2350	435	2	.	.	PROPN
eurjchem-2350	435	3	drug	drug	NOUN
eurjchem-2350	435	4	discov	discov	NOUN
eurjchem-2350	435	5	.	.	PUNCT
eurjchem-2350	436	1	2016	2016	NUM
eurjchem-2350	436	2	,	,	PUNCT
eurjchem-2350	436	3	15	15	NUM
eurjchem-2350	436	4	(	(	PUNCT
eurjchem-2350	436	5	5	5	NUM
eurjchem-2350	436	6	)	)	PUNCT
eurjchem-2350	436	7	,	,	PUNCT
eurjchem-2350	436	8	327–347	327–347	NUM
eurjchem-2350	436	9	.	.	PUNCT
eurjchem-2350	437	1	[	[	X
eurjchem-2350	437	2	55	55	NUM
eurjchem-2350	437	3	]	]	PUNCT
eurjchem-2350	437	4	.	.	PUNCT
eurjchem-2350	438	1	zhang	zhang	PROPN
eurjchem-2350	438	2	,	,	PUNCT
eurjchem-2350	438	3	w.	w.	PROPN
eurjchem-2350	438	4	;	;	PUNCT
eurjchem-2350	438	5	zhao	zhao	PROPN
eurjchem-2350	438	6	,	,	PUNCT
eurjchem-2350	438	7	y.	y.	PROPN
eurjchem-2350	438	8	;	;	PUNCT
eurjchem-2350	438	9	zhang	zhang	PROPN
eurjchem-2350	438	10	,	,	PUNCT
eurjchem-2350	438	11	f.	f.	PROPN
eurjchem-2350	438	12	;	;	PUNCT
eurjchem-2350	438	13	wang	wang	PROPN
eurjchem-2350	438	14	,	,	PUNCT
eurjchem-2350	438	15	q.	q.	PROPN
eurjchem-2350	438	16	;	;	PUNCT
eurjchem-2350	438	17	li	li	PROPN
eurjchem-2350	438	18	,	,	PUNCT
eurjchem-2350	438	19	t.	t.	PROPN
eurjchem-2350	438	20	;	;	PUNCT
eurjchem-2350	438	21	liu	liu	PROPN
eurjchem-2350	438	22	,	,	PUNCT
eurjchem-2350	438	23	z.	z.	PROPN
eurjchem-2350	438	24	;	;	PUNCT
eurjchem-2350	438	25	wang	wang	PROPN
eurjchem-2350	438	26	,	,	PUNCT
eurjchem-2350	438	27	j.	j.	PROPN
eurjchem-2350	438	28	;	;	PUNCT
eurjchem-2350	438	29	qin	qin	PROPN
eurjchem-2350	438	30	,	,	PUNCT
eurjchem-2350	438	31	y.	y.	PROPN
eurjchem-2350	438	32	;	;	PUNCT
eurjchem-2350	438	33	zhang	zhang	PROPN
eurjchem-2350	438	34	,	,	PUNCT
eurjchem-2350	438	35	x.	x.	PROPN
eurjchem-2350	438	36	;	;	PUNCT
eurjchem-2350	438	37	yan	yan	PROPN
eurjchem-2350	438	38	,	,	PUNCT
eurjchem-2350	438	39	x.	x.	PROPN
eurjchem-2350	438	40	;	;	PUNCT
eurjchem-2350	438	41	zeng	zeng	PROPN
eurjchem-2350	438	42	,	,	PUNCT
eurjchem-2350	438	43	x.	x.	PROPN
eurjchem-2350	438	44	;	;	PUNCT
eurjchem-2350	438	45	zhang	zhang	PROPN
eurjchem-2350	438	46	,	,	PUNCT
eurjchem-2350	438	47	s.	s.	PROPN
eurjchem-2350	438	48	the	the	DET
eurjchem-2350	438	49	use	use	NOUN
eurjchem-2350	438	50	of	of	ADP
eurjchem-2350	438	51	anti	anti	ADJ
eurjchem-2350	438	52	-	-	ADJ
eurjchem-2350	438	53	inflammatory	inflammatory	ADJ
eurjchem-2350	438	54	drugs	drug	NOUN
eurjchem-2350	438	55	in	in	ADP
eurjchem-2350	438	56	the	the	DET
eurjchem-2350	438	57	treatment	treatment	NOUN
eurjchem-2350	438	58	of	of	ADP
eurjchem-2350	438	59	people	people	NOUN
eurjchem-2350	438	60	with	with	ADP
eurjchem-2350	438	61	severe	severe	ADJ
eurjchem-2350	438	62	coronavirus	coronavirus	NOUN
eurjchem-2350	438	63	disease	disease	NOUN
eurjchem-2350	438	64	2019	2019	NUM
eurjchem-2350	438	65	(	(	PUNCT
eurjchem-2350	438	66	covid-19	covid-19	PROPN
eurjchem-2350	438	67	):	):	PUNCT
eurjchem-2350	438	68	the	the	DET
eurjchem-2350	438	69	perspectives	perspective	NOUN
eurjchem-2350	438	70	of	of	ADP
eurjchem-2350	438	71	clinical	clinical	ADJ
eurjchem-2350	438	72	immunologists	immunologist	NOUN
eurjchem-2350	438	73	from	from	ADP
eurjchem-2350	438	74	china	china	PROPN
eurjchem-2350	438	75	.	.	PUNCT
eurjchem-2350	439	1	clin	clin	PROPN
eurjchem-2350	439	2	.	.	PUNCT
eurjchem-2350	440	1	immunol	immunol	PROPN
eurjchem-2350	440	2	.	.	PUNCT
eurjchem-2350	441	1	2020	2020	NUM
eurjchem-2350	441	2	,	,	PUNCT
eurjchem-2350	441	3	214	214	NUM
eurjchem-2350	441	4	(	(	PUNCT
eurjchem-2350	441	5	108393	108393	NUM
eurjchem-2350	441	6	)	)	PUNCT
eurjchem-2350	441	7	,	,	PUNCT
eurjchem-2350	441	8	108393	108393	NUM
eurjchem-2350	441	9	.	.	PUNCT
eurjchem-2350	442	1	[	[	X
eurjchem-2350	442	2	56	56	NUM
eurjchem-2350	442	3	]	]	SYM
eurjchem-2350	442	4	.	.	PUNCT
eurjchem-2350	443	1	fantini	fantini	PROPN
eurjchem-2350	443	2	,	,	PUNCT
eurjchem-2350	443	3	j.	j.	PROPN
eurjchem-2350	443	4	;	;	PUNCT
eurjchem-2350	443	5	chahinian	chahinian	PROPN
eurjchem-2350	443	6	,	,	PUNCT
eurjchem-2350	443	7	h.	h.	PROPN
eurjchem-2350	443	8	;	;	PUNCT
eurjchem-2350	443	9	yahi	yahi	PROPN
eurjchem-2350	443	10	,	,	PUNCT
eurjchem-2350	443	11	n.	n.	PROPN
eurjchem-2350	443	12	synergistic	synergistic	ADJ
eurjchem-2350	443	13	antiviral	antiviral	ADJ
eurjchem-2350	443	14	effect	effect	NOUN
eurjchem-2350	443	15	of	of	ADP
eurjchem-2350	443	16	hydroxychloroquine	hydroxychloroquine	NOUN
eurjchem-2350	443	17	and	and	CCONJ
eurjchem-2350	443	18	azithromycin	azithromycin	VERB
eurjchem-2350	443	19	in	in	ADP
eurjchem-2350	443	20	combination	combination	NOUN
eurjchem-2350	443	21	against	against	ADP
eurjchem-2350	443	22	sarscov-2	sarscov-2	NUM
eurjchem-2350	443	23	:	:	PUNCT
eurjchem-2350	443	24	what	what	PRON
eurjchem-2350	443	25	molecular	molecular	ADJ
eurjchem-2350	443	26	dynamics	dynamic	NOUN
eurjchem-2350	443	27	studies	study	NOUN
eurjchem-2350	443	28	of	of	ADP
eurjchem-2350	443	29	virus	virus	NOUN
eurjchem-2350	443	30	-	-	PUNCT
eurjchem-2350	443	31	host	host	NOUN
eurjchem-2350	443	32	interactions	interaction	NOUN
eurjchem-2350	443	33	reveal	reveal	VERB
eurjchem-2350	443	34	.	.	PUNCT
eurjchem-2350	444	1	int	int	NOUN
eurjchem-2350	444	2	.	.	PUNCT
eurjchem-2350	445	1	j.	j.	PROPN
eurjchem-2350	445	2	antimicrob	antimicrob	PROPN
eurjchem-2350	445	3	.	.	PUNCT
eurjchem-2350	446	1	agents	agent	NOUN
eurjchem-2350	446	2	2020	2020	NUM
eurjchem-2350	446	3	,	,	PUNCT
eurjchem-2350	446	4	56	56	NUM
eurjchem-2350	446	5	(	(	PUNCT
eurjchem-2350	446	6	2	2	NUM
eurjchem-2350	446	7	)	)	PUNCT
eurjchem-2350	446	8	,	,	PUNCT
eurjchem-2350	446	9	106020	106020	NUM
eurjchem-2350	446	10	.	.	PUNCT
eurjchem-2350	447	1	[	[	X
eurjchem-2350	447	2	57	57	NUM
eurjchem-2350	447	3	]	]	PUNCT
eurjchem-2350	447	4	.	.	PUNCT
eurjchem-2350	447	5	schilling	schilling	NOUN
eurjchem-2350	447	6	,	,	PUNCT
eurjchem-2350	447	7	w.	w.	PROPN
eurjchem-2350	447	8	h.	h.	PROPN
eurjchem-2350	447	9	;	;	PUNCT
eurjchem-2350	447	10	white	white	ADJ
eurjchem-2350	447	11	,	,	PUNCT
eurjchem-2350	447	12	n.	n.	PROPN
eurjchem-2350	447	13	j.	j.	PROPN
eurjchem-2350	447	14	does	do	AUX
eurjchem-2350	447	15	hydroxychloroquine	hydroxychloroquine	PROPN
eurjchem-2350	447	16	still	still	ADV
eurjchem-2350	447	17	have	have	VERB
eurjchem-2350	447	18	any	any	DET
eurjchem-2350	447	19	role	role	NOUN
eurjchem-2350	447	20	in	in	ADP
eurjchem-2350	447	21	the	the	DET
eurjchem-2350	447	22	covid-19	covid-19	PROPN
eurjchem-2350	447	23	pandemic	pandemic	NOUN
eurjchem-2350	447	24	?	?	PUNCT
eurjchem-2350	448	1	expert	expert	NOUN
eurjchem-2350	448	2	opin	opin	NOUN
eurjchem-2350	448	3	.	.	PUNCT
eurjchem-2350	449	1	pharmacother	pharmacother	ADJ
eurjchem-2350	449	2	.	.	PUNCT
eurjchem-2350	450	1	2021	2021	NUM
eurjchem-2350	450	2	,	,	PUNCT
eurjchem-2350	450	3	22	22	NUM
eurjchem-2350	450	4	(	(	PUNCT
eurjchem-2350	450	5	10	10	NUM
eurjchem-2350	450	6	)	)	PUNCT
eurjchem-2350	450	7	,	,	PUNCT
eurjchem-2350	450	8	1257–1266	1257–1266	NUM
eurjchem-2350	450	9	.	.	PUNCT
eurjchem-2350	451	1	[	[	X
eurjchem-2350	451	2	58	58	NUM
eurjchem-2350	451	3	]	]	PUNCT
eurjchem-2350	451	4	.	.	PUNCT
eurjchem-2350	452	1	elfiky	elfiky	VERB
eurjchem-2350	452	2	,	,	PUNCT
eurjchem-2350	452	3	a.	a.	NOUN
eurjchem-2350	452	4	a.	a.	NOUN
eurjchem-2350	452	5	ribavirin	ribavirin	PROPN
eurjchem-2350	452	6	,	,	PUNCT
eurjchem-2350	452	7	remdesivir	remdesivir	PROPN
eurjchem-2350	452	8	,	,	PUNCT
eurjchem-2350	452	9	sofosbuvir	sofosbuvir	PROPN
eurjchem-2350	452	10	,	,	PUNCT
eurjchem-2350	452	11	galidesivir	galidesivir	PROPN
eurjchem-2350	452	12	,	,	PUNCT
eurjchem-2350	452	13	and	and	CCONJ
eurjchem-2350	452	14	tenofovir	tenofovir	NOUN
eurjchem-2350	452	15	against	against	ADP
eurjchem-2350	452	16	sars	sar	NOUN
eurjchem-2350	452	17	-	-	PUNCT
eurjchem-2350	452	18	cov-2	cov-2	NOUN
eurjchem-2350	452	19	rna	rna	NOUN
eurjchem-2350	452	20	dependent	dependent	ADJ
eurjchem-2350	452	21	rna	rna	NOUN
eurjchem-2350	452	22	polymerase	polymerase	NOUN
eurjchem-2350	452	23	(	(	PUNCT
eurjchem-2350	452	24	rdrp	rdrp	PROPN
eurjchem-2350	452	25	):	):	PUNCT
eurjchem-2350	452	26	a	a	DET
eurjchem-2350	452	27	molecular	molecular	ADJ
eurjchem-2350	452	28	docking	docking	NOUN
eurjchem-2350	452	29	study	study	NOUN
eurjchem-2350	452	30	.	.	PUNCT
eurjchem-2350	453	1	life	life	PROPN
eurjchem-2350	453	2	sci	sci	PROPN
eurjchem-2350	453	3	.	.	PROPN
eurjchem-2350	453	4	2020	2020	NUM
eurjchem-2350	453	5	,	,	PUNCT
eurjchem-2350	453	6	253	253	NUM
eurjchem-2350	453	7	(	(	PUNCT
eurjchem-2350	453	8	117592	117592	NUM
eurjchem-2350	453	9	)	)	PUNCT
eurjchem-2350	453	10	,	,	PUNCT
eurjchem-2350	453	11	117592	117592	NUM
eurjchem-2350	453	12	.	.	PUNCT
eurjchem-2350	454	1	[	[	X
eurjchem-2350	454	2	59	59	NUM
eurjchem-2350	454	3	]	]	PUNCT
eurjchem-2350	454	4	.	.	PUNCT
eurjchem-2350	455	1	majumder	majumder	PROPN
eurjchem-2350	455	2	,	,	PUNCT
eurjchem-2350	455	3	r.	r.	PROPN
eurjchem-2350	455	4	;	;	PUNCT
eurjchem-2350	455	5	mandal	mandal	PROPN
eurjchem-2350	455	6	,	,	PUNCT
eurjchem-2350	455	7	m.	m.	NOUN
eurjchem-2350	455	8	screening	screening	NOUN
eurjchem-2350	455	9	of	of	ADP
eurjchem-2350	455	10	plant	plant	NOUN
eurjchem-2350	455	11	-	-	PUNCT
eurjchem-2350	455	12	based	base	VERB
eurjchem-2350	455	13	natural	natural	ADJ
eurjchem-2350	455	14	compounds	compound	NOUN
eurjchem-2350	455	15	as	as	ADP
eurjchem-2350	455	16	a	a	DET
eurjchem-2350	455	17	potential	potential	ADJ
eurjchem-2350	455	18	covid-19	covid-19	PROPN
eurjchem-2350	455	19	main	main	ADJ
eurjchem-2350	455	20	protease	protease	NOUN
eurjchem-2350	455	21	inhibitor	inhibitor	NOUN
eurjchem-2350	455	22	:	:	PUNCT
eurjchem-2350	455	23	an	an	DET
eurjchem-2350	455	24	in	in	ADP
eurjchem-2350	455	25	silico	silico	NOUN
eurjchem-2350	455	26	docking	docking	NOUN
eurjchem-2350	455	27	and	and	CCONJ
eurjchem-2350	455	28	molecular	molecular	ADJ
eurjchem-2350	455	29	dynamics	dynamic	NOUN
eurjchem-2350	455	30	simulation	simulation	NOUN
eurjchem-2350	455	31	approach	approach	NOUN
eurjchem-2350	455	32	.	.	PUNCT
eurjchem-2350	456	1	j.	j.	PROPN
eurjchem-2350	456	2	biomol	biomol	PROPN
eurjchem-2350	456	3	.	.	PUNCT
eurjchem-2350	456	4	struct	struct	NOUN
eurjchem-2350	456	5	.	.	PUNCT
eurjchem-2350	457	1	dyn	dyn	NOUN
eurjchem-2350	457	2	.	.	PUNCT
eurjchem-2350	458	1	2022	2022	NUM
eurjchem-2350	458	2	,	,	PUNCT
eurjchem-2350	458	3	40	40	NUM
eurjchem-2350	458	4	,	,	PUNCT
eurjchem-2350	458	5	696–711	696–711	NUM
eurjchem-2350	458	6	.	.	PUNCT
eurjchem-2350	459	1	[	[	X
eurjchem-2350	459	2	60	60	NUM
eurjchem-2350	459	3	]	]	PUNCT
eurjchem-2350	459	4	.	.	PUNCT
eurjchem-2350	460	1	kajal	kajal	PROPN
eurjchem-2350	460	2	,	,	PUNCT
eurjchem-2350	460	3	k.	k.	PROPN
eurjchem-2350	460	4	;	;	PUNCT
eurjchem-2350	460	5	panda	panda	NOUN
eurjchem-2350	460	6	,	,	PUNCT
eurjchem-2350	460	7	a.	a.	PROPN
eurjchem-2350	460	8	k.	k.	PROPN
eurjchem-2350	460	9	;	;	PUNCT
eurjchem-2350	460	10	bhat	bhat	PROPN
eurjchem-2350	460	11	,	,	PUNCT
eurjchem-2350	460	12	j.	j.	PROPN
eurjchem-2350	460	13	;	;	PUNCT
eurjchem-2350	460	14	chakraborty	chakraborty	PROPN
eurjchem-2350	460	15	,	,	PUNCT
eurjchem-2350	460	16	d.	d.	PROPN
eurjchem-2350	460	17	;	;	PUNCT
eurjchem-2350	460	18	bose	bose	PROPN
eurjchem-2350	460	19	,	,	PUNCT
eurjchem-2350	460	20	s.	s.	PROPN
eurjchem-2350	460	21	;	;	PUNCT
eurjchem-2350	460	22	bhattacharjee	bhattacharjee	PROPN
eurjchem-2350	460	23	,	,	PUNCT
eurjchem-2350	460	24	p.	p.	PROPN
eurjchem-2350	460	25	;	;	PUNCT
eurjchem-2350	460	26	sarkar	sarkar	PROPN
eurjchem-2350	460	27	,	,	PUNCT
eurjchem-2350	460	28	t.	t.	PROPN
eurjchem-2350	460	29	;	;	PUNCT
eurjchem-2350	460	30	chatterjee	chatterjee	PROPN
eurjchem-2350	460	31	,	,	PUNCT
eurjchem-2350	460	32	s.	s.	PROPN
eurjchem-2350	460	33	;	;	PUNCT
eurjchem-2350	460	34	kar	kar	PROPN
eurjchem-2350	460	35	,	,	PUNCT
eurjchem-2350	460	36	s.	s.	PROPN
eurjchem-2350	460	37	k.	k.	PROPN
eurjchem-2350	460	38	;	;	PUNCT
eurjchem-2350	460	39	sa	sa	PROPN
eurjchem-2350	460	40	,	,	PUNCT
eurjchem-2350	460	41	g.	g.	PROPN
eurjchem-2350	460	42	andrographolide	andrographolide	ADV
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eurjchem-2350	460	44	to	to	ADP
eurjchem-2350	460	45	atp	atp	NOUN
eurjchem-2350	460	46	-	-	PUNCT
eurjchem-2350	460	47	binding	bind	VERB
eurjchem-2350	460	48	pocket	pocket	NOUN
eurjchem-2350	460	49	of	of	ADP
eurjchem-2350	460	50	vegfr2	vegfr2	NOUN
eurjchem-2350	460	51	to	to	PART
eurjchem-2350	460	52	impede	impede	VERB
eurjchem-2350	460	53	vegfa	vegfa	NOUN
eurjchem-2350	460	54	-	-	PUNCT
eurjchem-2350	460	55	mediated	mediate	VERB
eurjchem-2350	460	56	tumorangiogenesis	tumorangiogenesis	NOUN
eurjchem-2350	460	57	.	.	PUNCT
eurjchem-2350	461	1	sci	sci	PROPN
eurjchem-2350	461	2	.	.	PROPN
eurjchem-2350	461	3	rep	rep	PROPN
eurjchem-2350	461	4	.	.	PROPN
eurjchem-2350	461	5	2019	2019	NUM
eurjchem-2350	461	6	,	,	PUNCT
eurjchem-2350	461	7	9	9	NUM
eurjchem-2350	461	8	(	(	PUNCT
eurjchem-2350	461	9	1	1	NUM
eurjchem-2350	461	10	)	)	PUNCT
eurjchem-2350	461	11	,	,	PUNCT
eurjchem-2350	461	12	4073	4073	NUM
eurjchem-2350	461	13	.	.	PUNCT
eurjchem-2350	462	1	[	[	X
eurjchem-2350	462	2	61	61	NUM
eurjchem-2350	462	3	]	]	PUNCT
eurjchem-2350	462	4	.	.	PUNCT
eurjchem-2350	463	1	al	al	PROPN
eurjchem-2350	463	2	-	-	PUNCT
eurjchem-2350	463	3	jaidi	jaidi	PROPN
eurjchem-2350	463	4	,	,	PUNCT
eurjchem-2350	463	5	b.	b.	PROPN
eurjchem-2350	463	6	a.	a.	PROPN
eurjchem-2350	463	7	;	;	PUNCT
eurjchem-2350	463	8	telfah	telfah	PROPN
eurjchem-2350	463	9	,	,	PUNCT
eurjchem-2350	463	10	s.	s.	PROPN
eurjchem-2350	463	11	t.	t.	PROPN
eurjchem-2350	463	12	;	;	PUNCT
eurjchem-2350	463	13	bardaweel	bardaweel	NOUN
eurjchem-2350	463	14	,	,	PUNCT
eurjchem-2350	463	15	s.	s.	PROPN
eurjchem-2350	463	16	k.	k.	PROPN
eurjchem-2350	463	17	;	;	PUNCT
eurjchem-2350	463	18	deb	deb	PROPN
eurjchem-2350	463	19	,	,	PUNCT
eurjchem-2350	463	20	p.	p.	PROPN
eurjchem-2350	463	21	k.	k.	PROPN
eurjchem-2350	463	22	;	;	PUNCT
eurjchem-2350	464	1	borah	borah	PROPN
eurjchem-2350	464	2	,	,	PUNCT
eurjchem-2350	464	3	p.	p.	NOUN
eurjchem-2350	464	4	;	;	PUNCT
eurjchem-2350	464	5	venugopala	venugopala	NOUN
eurjchem-2350	464	6	,	,	PUNCT
eurjchem-2350	464	7	k.	k.	PROPN
eurjchem-2350	464	8	n.	n.	PROPN
eurjchem-2350	464	9	;	;	PUNCT
eurjchem-2350	464	10	bataineh	bataineh	PROPN
eurjchem-2350	464	11	,	,	PUNCT
eurjchem-2350	464	12	y.	y.	PROPN
eurjchem-2350	464	13	a.	a.	PROPN
eurjchem-2350	464	14	;	;	PUNCT
eurjchem-2350	464	15	al	al	PROPN
eurjchem-2350	464	16	khames	khames	PROPN
eurjchem-2350	464	17	aga	aga	PROPN
eurjchem-2350	464	18	,	,	PUNCT
eurjchem-2350	464	19	q.	q.	PROPN
eurjchem-2350	464	20	a.	a.	NOUN
eurjchem-2350	464	21	anticancer	anticancer	NOUN
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eurjchem-2350	464	25	silico	silico	NOUN
eurjchem-2350	464	26	admet	admet	NOUN
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eurjchem-2350	464	30	-	-	PUNCT
eurjchem-2350	464	31	trisubstituted	trisubstitute	VERB
eurjchem-2350	464	32	thiazole	thiazole	NOUN
eurjchem-2350	464	33	derivatives	derivative	NOUN
eurjchem-2350	464	34	.	.	PUNCT
eurjchem-2350	465	1	curr	curr	PROPN
eurjchem-2350	465	2	.	.	PUNCT
eurjchem-2350	465	3	drug	drug	PROPN
eurjchem-2350	465	4	metab	metab	NOUN
eurjchem-2350	465	5	.	.	PUNCT
eurjchem-2350	466	1	2020	2020	NUM
eurjchem-2350	466	2	,	,	PUNCT
eurjchem-2350	466	3	21	21	NUM
eurjchem-2350	466	4	.	.	PUNCT
eurjchem-2350	467	1	https://doi.org/10.2174/1389200221666201217094602	https://doi.org/10.2174/1389200221666201217094602	X
eurjchem-2350	467	2	.	.	PUNCT
eurjchem-2350	468	1	copyright	copyright	NOUN
eurjchem-2350	468	2	©	©	ADP
eurjchem-2350	468	3	2023	2023	NUM
eurjchem-2350	468	4	by	by	ADP
eurjchem-2350	468	5	authors	author	NOUN
eurjchem-2350	468	6	.	.	PUNCT
eurjchem-2350	469	1	this	this	DET
eurjchem-2350	469	2	work	work	NOUN
eurjchem-2350	469	3	is	be	AUX
eurjchem-2350	469	4	published	publish	VERB
eurjchem-2350	469	5	and	and	CCONJ
eurjchem-2350	469	6	licensed	license	VERB
eurjchem-2350	469	7	by	by	ADP
eurjchem-2350	469	8	atlanta	atlanta	PROPN
eurjchem-2350	469	9	publishing	publishing	PROPN
eurjchem-2350	469	10	house	house	PROPN
eurjchem-2350	469	11	llc	llc	PROPN
eurjchem-2350	469	12	,	,	PUNCT
eurjchem-2350	469	13	atlanta	atlanta	PROPN
eurjchem-2350	469	14	,	,	PUNCT
eurjchem-2350	469	15	ga	ga	PROPN
eurjchem-2350	469	16	,	,	PUNCT
eurjchem-2350	469	17	usa	usa	PROPN
eurjchem-2350	469	18	.	.	PUNCT
eurjchem-2350	470	1	the	the	DET
eurjchem-2350	470	2	full	full	ADJ
eurjchem-2350	470	3	terms	term	NOUN
eurjchem-2350	470	4	of	of	ADP
eurjchem-2350	470	5	this	this	DET
eurjchem-2350	470	6	license	license	NOUN
eurjchem-2350	470	7	are	be	AUX
eurjchem-2350	470	8	available	available	ADJ
eurjchem-2350	470	9	at	at	ADP
eurjchem-2350	470	10	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	NOUN
eurjchem-2350	470	11	and	and	CCONJ
eurjchem-2350	470	12	incorporate	incorporate	VERB
eurjchem-2350	470	13	the	the	DET
eurjchem-2350	470	14	creative	creative	ADJ
eurjchem-2350	470	15	commons	common	NOUN
eurjchem-2350	470	16	attribution	attribution	NOUN
eurjchem-2350	470	17	-	-	PUNCT
eurjchem-2350	470	18	non	non	ADJ
eurjchem-2350	470	19	commercial	commercial	NOUN
eurjchem-2350	470	20	(	(	PUNCT
eurjchem-2350	470	21	cc	cc	NOUN
eurjchem-2350	470	22	by	by	ADP
eurjchem-2350	470	23	nc	nc	PROPN
eurjchem-2350	470	24	)	)	PUNCT
eurjchem-2350	470	25	(	(	PUNCT
eurjchem-2350	470	26	international	international	ADJ
eurjchem-2350	470	27	,	,	PUNCT
eurjchem-2350	470	28	v4.0	v4.0	NOUN
eurjchem-2350	470	29	)	)	PUNCT
eurjchem-2350	470	30	license	license	NOUN
eurjchem-2350	470	31	(	(	PUNCT
eurjchem-2350	470	32	http://creativecommons.org/licenses/by-nc/4.0	http://creativecommons.org/licenses/by-nc/4.0	NOUN
eurjchem-2350	470	33	)	)	PUNCT
eurjchem-2350	470	34	.	.	PUNCT
eurjchem-2350	471	1	by	by	ADP
eurjchem-2350	471	2	accessing	access	VERB
eurjchem-2350	471	3	the	the	DET
eurjchem-2350	471	4	work	work	NOUN
eurjchem-2350	471	5	,	,	PUNCT
eurjchem-2350	471	6	you	you	PRON
eurjchem-2350	471	7	hereby	hereby	ADV
eurjchem-2350	471	8	accept	accept	VERB
eurjchem-2350	471	9	the	the	DET
eurjchem-2350	471	10	terms	term	NOUN
eurjchem-2350	471	11	.	.	PUNCT
eurjchem-2350	472	1	this	this	PRON
eurjchem-2350	472	2	is	be	AUX
eurjchem-2350	472	3	an	an	DET
eurjchem-2350	472	4	open	open	ADJ
eurjchem-2350	472	5	access	access	NOUN
eurjchem-2350	472	6	article	article	NOUN
eurjchem-2350	472	7	distributed	distribute	VERB
eurjchem-2350	472	8	under	under	ADP
eurjchem-2350	472	9	the	the	DET
eurjchem-2350	472	10	terms	term	NOUN
eurjchem-2350	472	11	and	and	CCONJ
eurjchem-2350	472	12	conditions	condition	NOUN
eurjchem-2350	472	13	of	of	ADP
eurjchem-2350	472	14	the	the	DET
eurjchem-2350	472	15	cc	cc	PROPN
eurjchem-2350	472	16	by	by	ADP
eurjchem-2350	472	17	nc	nc	PROPN
eurjchem-2350	472	18	license	license	PROPN
eurjchem-2350	472	19	,	,	PUNCT
eurjchem-2350	472	20	which	which	PRON
eurjchem-2350	472	21	permits	permit	VERB
eurjchem-2350	472	22	unrestricted	unrestricted	ADJ
eurjchem-2350	472	23	non	non	ADJ
eurjchem-2350	472	24	-	-	ADJ
eurjchem-2350	472	25	commercial	commercial	ADJ
eurjchem-2350	472	26	use	use	NOUN
eurjchem-2350	472	27	,	,	PUNCT
eurjchem-2350	472	28	distribution	distribution	NOUN
eurjchem-2350	472	29	,	,	PUNCT
eurjchem-2350	472	30	and	and	CCONJ
eurjchem-2350	472	31	reproduction	reproduction	NOUN
eurjchem-2350	472	32	in	in	ADP
eurjchem-2350	472	33	any	any	DET
eurjchem-2350	472	34	medium	medium	NOUN
eurjchem-2350	472	35	,	,	PUNCT
eurjchem-2350	472	36	provided	provide	VERB
eurjchem-2350	472	37	the	the	DET
eurjchem-2350	472	38	original	original	ADJ
eurjchem-2350	472	39	work	work	NOUN
eurjchem-2350	472	40	is	be	AUX
eurjchem-2350	472	41	properly	properly	ADV
eurjchem-2350	472	42	cited	cite	VERB
eurjchem-2350	472	43	without	without	ADP
eurjchem-2350	472	44	any	any	DET
eurjchem-2350	472	45	further	further	ADJ
eurjchem-2350	472	46	permission	permission	NOUN
eurjchem-2350	472	47	from	from	ADP
eurjchem-2350	472	48	atlanta	atlanta	PROPN
eurjchem-2350	472	49	publishing	publishing	PROPN
eurjchem-2350	472	50	house	house	PROPN
eurjchem-2350	472	51	llc	llc	PROPN
eurjchem-2350	472	52	(	(	PUNCT
eurjchem-2350	472	53	european	european	PROPN
eurjchem-2350	472	54	journal	journal	PROPN
eurjchem-2350	472	55	of	of	ADP
eurjchem-2350	472	56	chemistry	chemistry	NOUN
eurjchem-2350	472	57	)	)	PUNCT
eurjchem-2350	472	58	.	.	PUNCT
eurjchem-2350	473	1	no	no	DET
eurjchem-2350	473	2	use	use	NOUN
eurjchem-2350	473	3	,	,	PUNCT
eurjchem-2350	473	4	distribution	distribution	NOUN
eurjchem-2350	473	5	,	,	PUNCT
eurjchem-2350	473	6	or	or	CCONJ
eurjchem-2350	473	7	reproduction	reproduction	NOUN
eurjchem-2350	473	8	is	be	AUX
eurjchem-2350	473	9	permitted	permit	VERB
eurjchem-2350	473	10	which	which	PRON
eurjchem-2350	473	11	does	do	AUX
eurjchem-2350	473	12	not	not	PART
eurjchem-2350	473	13	comply	comply	VERB
eurjchem-2350	473	14	with	with	ADP
eurjchem-2350	473	15	these	these	DET
eurjchem-2350	473	16	terms	term	NOUN
eurjchem-2350	473	17	.	.	PUNCT
eurjchem-2350	474	1	permissions	permission	NOUN
eurjchem-2350	474	2	for	for	ADP
eurjchem-2350	474	3	commercial	commercial	ADJ
eurjchem-2350	474	4	use	use	NOUN
eurjchem-2350	474	5	of	of	ADP
eurjchem-2350	474	6	this	this	DET
eurjchem-2350	474	7	work	work	NOUN
eurjchem-2350	474	8	beyond	beyond	ADP
eurjchem-2350	474	9	the	the	DET
eurjchem-2350	474	10	scope	scope	NOUN
eurjchem-2350	474	11	of	of	ADP
eurjchem-2350	474	12	the	the	DET
eurjchem-2350	474	13	license	license	NOUN
eurjchem-2350	474	14	(	(	PUNCT
eurjchem-2350	474	15	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	NOUN
eurjchem-2350	474	16	)	)	PUNCT
eurjchem-2350	474	17	are	be	AUX
eurjchem-2350	474	18	administered	administer	VERB
eurjchem-2350	474	19	by	by	ADP
eurjchem-2350	474	20	atlanta	atlanta	PROPN
eurjchem-2350	474	21	publishing	publishing	PROPN
eurjchem-2350	474	22	house	house	PROPN
eurjchem-2350	474	23	llc	llc	PROPN
eurjchem-2350	474	24	(	(	PUNCT
eurjchem-2350	474	25	european	european	PROPN
eurjchem-2350	474	26	journal	journal	PROPN
eurjchem-2350	474	27	of	of	ADP
eurjchem-2350	474	28	chemistry	chemistry	NOUN
eurjchem-2350	474	29	)	)	PUNCT
eurjchem-2350	474	30	.	.	PUNCT
eurjchem-2350	474	31	https://doi.org/10.2174/1389200221666201217094602	https://doi.org/10.2174/1389200221666201217094602	PUNCT
eurjchem-2350	475	1	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	NOUN
eurjchem-2350	475	2	http://creativecommons.org/licenses/by-nc/4.0	http://creativecommons.org/licenses/by-nc/4.0	PROPN
eurjchem-2350	475	3	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	NOUN
eurjchem-2350	475	4	1	1	NUM
eurjchem-2350	475	5	.	.	PUNCT
eurjchem-2350	475	6	introduction	introduction	NOUN
eurjchem-2350	475	7	2	2	NUM
eurjchem-2350	475	8	.	.	PUNCT
eurjchem-2350	475	9	experimental	experimental	ADJ
eurjchem-2350	475	10	2.1	2.1	NUM
eurjchem-2350	475	11	.	.	PUNCT
eurjchem-2350	476	1	quinolines	quinoline	NOUN
eurjchem-2350	476	2	as	as	ADP
eurjchem-2350	476	3	potential	potential	ADJ
eurjchem-2350	476	4	drug	drug	NOUN
eurjchem-2350	476	5	molecules	molecule	NOUN
eurjchem-2350	476	6	2.2	2.2	NUM
eurjchem-2350	476	7	.	.	PUNCT
eurjchem-2350	476	8	ligand	ligand	ADJ
eurjchem-2350	476	9	preparation	preparation	NOUN
eurjchem-2350	476	10	and	and	CCONJ
eurjchem-2350	476	11	analysis	analysis	NOUN
eurjchem-2350	476	12	2.3	2.3	NUM
eurjchem-2350	476	13	.	.	PUNCT
eurjchem-2350	477	1	protein	protein	NOUN
eurjchem-2350	477	2	preparation	preparation	NOUN
eurjchem-2350	477	3	2.4	2.4	NUM
eurjchem-2350	477	4	.	.	PUNCT
eurjchem-2350	478	1	prediction	prediction	NOUN
eurjchem-2350	478	2	of	of	ADP
eurjchem-2350	478	3	active	active	ADJ
eurjchem-2350	478	4	sites	site	NOUN
eurjchem-2350	478	5	2.5	2.5	NUM
eurjchem-2350	478	6	.	.	PUNCT
eurjchem-2350	479	1	molecular	molecular	ADJ
eurjchem-2350	479	2	docking	docking	NOUN
eurjchem-2350	479	3	and	and	CCONJ
eurjchem-2350	479	4	analysis	analysis	NOUN
eurjchem-2350	479	5	2.6	2.6	NUM
eurjchem-2350	479	6	.	.	PUNCT
eurjchem-2350	480	1	prediction	prediction	NOUN
eurjchem-2350	480	2	of	of	ADP
eurjchem-2350	480	3	adme	adme	NOUN
eurjchem-2350	480	4	descriptors	descriptor	NOUN
eurjchem-2350	480	5	and	and	CCONJ
eurjchem-2350	480	6	toxicity	toxicity	NOUN
eurjchem-2350	480	7	of	of	ADP
eurjchem-2350	480	8	quinoline	quinoline	NOUN
eurjchem-2350	480	9	derivatives	derivative	NOUN
eurjchem-2350	480	10	.	.	PUNCT
eurjchem-2350	481	1	2.7	2.7	NUM
eurjchem-2350	481	2	.	.	X
eurjchem-2350	482	1	molecular	molecular	ADJ
eurjchem-2350	482	2	dynamic	dynamic	ADJ
eurjchem-2350	482	3	simulation	simulation	NOUN
eurjchem-2350	482	4	3	3	NUM
eurjchem-2350	482	5	.	.	NOUN
eurjchem-2350	482	6	results	result	NOUN
eurjchem-2350	482	7	and	and	CCONJ
eurjchem-2350	482	8	discussion	discussion	NOUN
eurjchem-2350	482	9	3.1	3.1	NUM
eurjchem-2350	482	10	.	.	PUNCT
eurjchem-2350	483	1	adme	adme	NOUN
eurjchem-2350	483	2	and	and	CCONJ
eurjchem-2350	483	3	toxicity	toxicity	NOUN
eurjchem-2350	483	4	studies	study	NOUN
eurjchem-2350	483	5	3.2	3.2	NUM
eurjchem-2350	483	6	.	.	PUNCT
eurjchem-2350	484	1	molecular	molecular	ADJ
eurjchem-2350	484	2	docking	docking	NOUN
eurjchem-2350	484	3	studies	study	NOUN
eurjchem-2350	484	4	of	of	ADP
eurjchem-2350	484	5	quinolines	quinoline	NOUN
eurjchem-2350	484	6	3.3	3.3	NUM
eurjchem-2350	484	7	.	.	PUNCT
eurjchem-2350	485	1	molecular	molecular	ADJ
eurjchem-2350	485	2	dynamic	dynamic	ADJ
eurjchem-2350	485	3	simulation	simulation	NOUN
eurjchem-2350	485	4	studies	study	NOUN
eurjchem-2350	485	5	4	4	NUM
eurjchem-2350	485	6	.	.	PUNCT
eurjchem-2350	486	1	conclusions	conclusion	NOUN
eurjchem-2350	486	2	disclosure	disclosure	NOUN
eurjchem-2350	486	3	statement	statement	NOUN
eurjchem-2350	486	4	credit	credit	NOUN
eurjchem-2350	486	5	authorship	authorship	NOUN
eurjchem-2350	486	6	contribution	contribution	NOUN
eurjchem-2350	486	7	statement	statement	NOUN
eurjchem-2350	486	8	orcid	orcid	NOUN
eurjchem-2350	486	9	and	and	CCONJ
eurjchem-2350	486	10	email	email	NOUN
eurjchem-2350	486	11	references	reference	NOUN
eurjchem-2350	486	12	printfield10	printfield10	PROPN
eurjchem-2350	486	13	:	:	PUNCT
eurjchem-2350	486	14	printfield11	printfield11	NOUN
eurjchem-2350	486	15	:	:	PUNCT
eurjchem-2350	486	16	printfield12	printfield12	PROPN
eurjchem-2350	486	17	:	:	PUNCT
eurjchem-2350	486	18	printfield13	printfield13	VERB
eurjchem-2350	486	19	:	:	PUNCT
eurjchem-2350	486	20	printfield14	printfield14	NOUN
eurjchem-2350	486	21	:	:	PUNCT
eurjchem-2350	486	22	printfield15	printfield15	NOUN
eurjchem-2350	486	23	:	:	PUNCT
eurjchem-2350	486	24	printfield16	printfield16	ADJ
eurjchem-2350	486	25	:	:	PUNCT
eurjchem-2350	486	26	printfield17	printfield17	NOUN
eurjchem-2350	486	27	:	:	PUNCT
eurjchem-2350	486	28	printfield18	printfield18	NOUN
eurjchem-2350	486	29	:	:	PUNCT
eurjchem-2350	486	30	printfield20	printfield20	PROPN
eurjchem-2350	486	31	:	:	PUNCT
eurjchem-2350	487	1	printfield21	printfield21	ADJ
eurjchem-2350	487	2	:	:	PUNCT
eurjchem-2350	487	3	printfield22	printfield22	NOUN
eurjchem-2350	487	4	:	:	PUNCT
eurjchem-2350	487	5	printfield23	printfield23	NOUN
eurjchem-2350	487	6	:	:	PUNCT
eurjchem-2350	487	7	printfield24	printfield24	NOUN
eurjchem-2350	487	8	:	:	PUNCT
eurjchem-2350	487	9	printfield25	printfield25	NOUN
eurjchem-2350	487	10	:	:	PUNCT
eurjchem-2350	487	11	printfield26	printfield26	ADJ
eurjchem-2350	487	12	:	:	PUNCT
eurjchem-2350	487	13	printfield27	printfield27	NOUN
eurjchem-2350	487	14	:	:	PUNCT
eurjchem-2350	487	15	printfield28	printfield28	NOUN
eurjchem-2350	487	16	:	:	PUNCT