id	sid	tid	token	lemma	pos
eurjchem-2455	1	1	a	a	DET
eurjchem-2455	1	2	quantum	quantum	ADJ
eurjchem-2455	1	3	chemistry	chemistry	NOUN
eurjchem-2455	1	4	background	background	NOUN
eurjchem-2455	1	5	of	of	ADP
eurjchem-2455	1	6	sickle	sickle	PROPN
eurjchem-2455	1	7	cell	cell	NOUN
eurjchem-2455	1	8	anemia	anemia	NOUN
eurjchem-2455	1	9	and	and	CCONJ
eurjchem-2455	1	10	gaps	gap	NOUN
eurjchem-2455	1	11	in	in	ADP
eurjchem-2455	1	12	antisickling	antisickle	VERB
eurjchem-2455	1	13	drug	drug	NOUN
eurjchem-2455	1	14	development	development	PROPN
eurjchem-2455	1	15	european	european	PROPN
eurjchem-2455	1	16	journal	journal	PROPN
eurjchem-2455	1	17	of	of	ADP
eurjchem-2455	1	18	chemistry	chemistry	NOUN
eurjchem-2455	1	19	14	14	NUM
eurjchem-2455	1	20	(	(	PUNCT
eurjchem-2455	1	21	3	3	NUM
eurjchem-2455	1	22	)	)	PUNCT
eurjchem-2455	1	23	(	(	PUNCT
eurjchem-2455	1	24	2023	2023	NUM
eurjchem-2455	1	25	)	)	PUNCT
eurjchem-2455	1	26	370	370	NUM
eurjchem-2455	1	27	-	-	SYM
eurjchem-2455	1	28	375	375	NUM
eurjchem-2455	1	29	european	european	ADJ
eurjchem-2455	1	30	journal	journal	NOUN
eurjchem-2455	1	31	of	of	ADP
eurjchem-2455	1	32	chemistry	chemistry	NOUN
eurjchem-2455	1	33	issn	issn	VERB
eurjchem-2455	1	34	2153	2153	NUM
eurjchem-2455	1	35	-	-	SYM
eurjchem-2455	1	36	2249	2249	NUM
eurjchem-2455	1	37	(	(	PUNCT
eurjchem-2455	1	38	print	print	NOUN
eurjchem-2455	1	39	)	)	PUNCT
eurjchem-2455	1	40	/	/	PUNCT
eurjchem-2455	1	41	issn	issn	PROPN
eurjchem-2455	1	42	2153	2153	NUM
eurjchem-2455	1	43	-	-	SYM
eurjchem-2455	1	44	2257	2257	NUM
eurjchem-2455	1	45	(	(	PUNCT
eurjchem-2455	1	46	online	online	ADJ
eurjchem-2455	1	47	)	)	PUNCT
eurjchem-2455	1	48	–	–	PUNCT
eurjchem-2455	2	1	copyright	copyright	NOUN
eurjchem-2455	2	2	©	©	PROPN
eurjchem-2455	2	3	2023	2023	NUM
eurjchem-2455	2	4	the	the	DET
eurjchem-2455	2	5	authors	author	NOUN
eurjchem-2455	2	6	–	–	PUNCT
eurjchem-2455	2	7	atlanta	atlanta	PROPN
eurjchem-2455	2	8	publishing	publishing	PROPN
eurjchem-2455	2	9	house	house	PROPN
eurjchem-2455	2	10	llc	llc	PROPN
eurjchem-2455	2	11	–	–	PUNCT
eurjchem-2455	2	12	printed	print	VERB
eurjchem-2455	2	13	in	in	ADP
eurjchem-2455	2	14	the	the	DET
eurjchem-2455	2	15	usa	usa	PROPN
eurjchem-2455	2	16	.	.	PUNCT
eurjchem-2455	3	1	this	this	DET
eurjchem-2455	3	2	work	work	NOUN
eurjchem-2455	3	3	is	be	AUX
eurjchem-2455	3	4	published	publish	VERB
eurjchem-2455	3	5	and	and	CCONJ
eurjchem-2455	3	6	licensed	license	VERB
eurjchem-2455	3	7	by	by	ADP
eurjchem-2455	3	8	atlanta	atlanta	PROPN
eurjchem-2455	3	9	publishing	publishing	PROPN
eurjchem-2455	3	10	house	house	PROPN
eurjchem-2455	3	11	llc	llc	PROPN
eurjchem-2455	3	12	–	–	PUNCT
eurjchem-2455	3	13	cc	cc	PROPN
eurjchem-2455	3	14	by	by	ADP
eurjchem-2455	3	15	nc	nc	PROPN
eurjchem-2455	3	16	–	–	PUNCT
eurjchem-2455	3	17	some	some	DET
eurjchem-2455	3	18	rights	right	NOUN
eurjchem-2455	3	19	reserved	reserve	VERB
eurjchem-2455	3	20	.	.	PUNCT
eurjchem-2455	4	1	https://dx.doi.org/10.5155/eurjchem.14.3.370-375.2455	https://dx.doi.org/10.5155/eurjchem.14.3.370-375.2455	PROPN
eurjchem-2455	4	2	european	european	PROPN
eurjchem-2455	4	3	journal	journal	PROPN
eurjchem-2455	4	4	of	of	ADP
eurjchem-2455	4	5	chemistry	chemistry	NOUN
eurjchem-2455	4	6	view	view	NOUN
eurjchem-2455	4	7	journal	journal	PROPN
eurjchem-2455	4	8	online	online	PROPN
eurjchem-2455	4	9	view	view	NOUN
eurjchem-2455	4	10	article	article	NOUN
eurjchem-2455	4	11	online	online	VERB
eurjchem-2455	4	12	a	a	DET
eurjchem-2455	4	13	quantum	quantum	ADJ
eurjchem-2455	4	14	chemistry	chemistry	NOUN
eurjchem-2455	4	15	background	background	NOUN
eurjchem-2455	4	16	of	of	ADP
eurjchem-2455	4	17	sickle	sickle	PROPN
eurjchem-2455	4	18	cell	cell	NOUN
eurjchem-2455	4	19	anemia	anemia	NOUN
eurjchem-2455	4	20	and	and	CCONJ
eurjchem-2455	4	21	gaps	gap	NOUN
eurjchem-2455	4	22	in	in	ADP
eurjchem-2455	4	23	antisickling	antisickle	VERB
eurjchem-2455	4	24	drug	drug	NOUN
eurjchem-2455	4	25	development	development	NOUN
eurjchem-2455	4	26	mohammad	mohammad	PROPN
eurjchem-2455	4	27	suhail	suhail	PROPN
eurjchem-2455	4	28	1	1	NUM
eurjchem-2455	4	29	,	,	PUNCT
eurjchem-2455	4	30	*	*	PUNCT
eurjchem-2455	4	31	,	,	PUNCT
eurjchem-2455	4	32	safwana	safwana	PROPN
eurjchem-2455	4	33	usmani	usmani	ADJ
eurjchem-2455	4	34	2	2	NUM
eurjchem-2455	4	35	and	and	CCONJ
eurjchem-2455	4	36	mehmood	mehmood	PROPN
eurjchem-2455	4	37	ahmad	ahmad	PROPN
eurjchem-2455	4	38	3	3	NUM
eurjchem-2455	4	39	1	1	NUM
eurjchem-2455	4	40	department	department	NOUN
eurjchem-2455	4	41	of	of	ADP
eurjchem-2455	4	42	chemistry	chemistry	NOUN
eurjchem-2455	4	43	,	,	PUNCT
eurjchem-2455	4	44	siddhartha	siddhartha	PROPN
eurjchem-2455	4	45	(	(	PUNCT
eurjchem-2455	4	46	p.g	p.g	PROPN
eurjchem-2455	4	47	.	.	PROPN
eurjchem-2455	4	48	)	)	PUNCT
eurjchem-2455	5	1	college	college	NOUN
eurjchem-2455	5	2	,	,	PUNCT
eurjchem-2455	5	3	aakhlaur	aakhlaur	PROPN
eurjchem-2455	5	4	kheri	kheri	PROPN
eurjchem-2455	5	5	(	(	PUNCT
eurjchem-2455	5	6	saharanpur	saharanpur	NOUN
eurjchem-2455	5	7	)	)	PUNCT
eurjchem-2455	5	8	,	,	PUNCT
eurjchem-2455	5	9	uttar	uttar	PROPN
eurjchem-2455	5	10	pradesh-247554	pradesh-247554	PROPN
eurjchem-2455	5	11	,	,	PUNCT
eurjchem-2455	5	12	india	india	PROPN
eurjchem-2455	5	13	2	2	NUM
eurjchem-2455	5	14	department	department	NOUN
eurjchem-2455	5	15	of	of	ADP
eurjchem-2455	5	16	biosciences	bioscience	NOUN
eurjchem-2455	5	17	,	,	PUNCT
eurjchem-2455	5	18	jamia	jamia	PROPN
eurjchem-2455	5	19	millia	millia	PROPN
eurjchem-2455	5	20	islamia	islamia	PROPN
eurjchem-2455	5	21	(	(	PUNCT
eurjchem-2455	5	22	a	a	DET
eurjchem-2455	5	23	central	central	ADJ
eurjchem-2455	5	24	university	university	NOUN
eurjchem-2455	5	25	)	)	PUNCT
eurjchem-2455	5	26	,	,	PUNCT
eurjchem-2455	5	27	new	new	ADJ
eurjchem-2455	5	28	delhi-110025	delhi-110025	NOUN
eurjchem-2455	5	29	,	,	PUNCT
eurjchem-2455	5	30	india	india	PROPN
eurjchem-2455	5	31	3	3	NUM
eurjchem-2455	5	32	department	department	NOUN
eurjchem-2455	5	33	of	of	ADP
eurjchem-2455	5	34	chemistry	chemistry	NOUN
eurjchem-2455	5	35	,	,	PUNCT
eurjchem-2455	5	36	bhaila	bhaila	PROPN
eurjchem-2455	5	37	(	(	PUNCT
eurjchem-2455	5	38	p.g	p.g	PROPN
eurjchem-2455	5	39	.	.	PROPN
eurjchem-2455	5	40	)	)	PUNCT
eurjchem-2455	6	1	college	college	NOUN
eurjchem-2455	6	2	,	,	PUNCT
eurjchem-2455	6	3	deoband	deoband	ADJ
eurjchem-2455	6	4	(	(	PUNCT
eurjchem-2455	6	5	saharanpur	saharanpur	NOUN
eurjchem-2455	6	6	)	)	PUNCT
eurjchem-2455	6	7	,	,	PUNCT
eurjchem-2455	6	8	uttar	uttar	PROPN
eurjchem-2455	6	9	pradesh-247554	pradesh-247554	PROPN
eurjchem-2455	6	10	,	,	PUNCT
eurjchem-2455	6	11	india	india	PROPN
eurjchem-2455	6	12	*	*	PUNCT
eurjchem-2455	6	13	corresponding	correspond	VERB
eurjchem-2455	6	14	author	author	NOUN
eurjchem-2455	6	15	at	at	ADP
eurjchem-2455	6	16	:	:	PUNCT
eurjchem-2455	6	17	department	department	NOUN
eurjchem-2455	6	18	of	of	ADP
eurjchem-2455	6	19	chemistry	chemistry	PROPN
eurjchem-2455	6	20	,	,	PUNCT
eurjchem-2455	6	21	siddhartha	siddhartha	PROPN
eurjchem-2455	6	22	(	(	PUNCT
eurjchem-2455	6	23	p.g	p.g	PROPN
eurjchem-2455	6	24	.	.	PROPN
eurjchem-2455	6	25	)	)	PUNCT
eurjchem-2455	7	1	college	college	NOUN
eurjchem-2455	7	2	,	,	PUNCT
eurjchem-2455	7	3	aakhlaur	aakhlaur	PROPN
eurjchem-2455	7	4	kheri	kheri	PROPN
eurjchem-2455	7	5	(	(	PUNCT
eurjchem-2455	7	6	saharanpur	saharanpur	NOUN
eurjchem-2455	7	7	)	)	PUNCT
eurjchem-2455	7	8	,	,	PUNCT
eurjchem-2455	7	9	uttar	uttar	PROPN
eurjchem-2455	7	10	pradesh-247554	pradesh-247554	PROPN
eurjchem-2455	7	11	,	,	PUNCT
eurjchem-2455	7	12	india	india	PROPN
eurjchem-2455	7	13	.	.	PUNCT
eurjchem-2455	8	1	e	e	X
eurjchem-2455	8	2	-	-	NOUN
eurjchem-2455	8	3	mail	mail	NOUN
eurjchem-2455	8	4	:	:	PUNCT
eurjchem-2455	8	5	suhailchem.786@gmail.com	suhailchem.786@gmail.com	X
eurjchem-2455	8	6	(	(	PUNCT
eurjchem-2455	8	7	m.	m.	NOUN
eurjchem-2455	8	8	suhail	suhail	PROPN
eurjchem-2455	8	9	)	)	PUNCT
eurjchem-2455	8	10	.	.	PUNCT
eurjchem-2455	9	1	10.5155	10.5155	NUM
eurjchem-2455	9	2	/	/	SYM
eurjchem-2455	9	3	eurjchem.14.3.370	eurjchem.14.3.370	NUM
eurjchem-2455	9	4	-	-	PUNCT
eurjchem-2455	9	5	375.2455	375.2455	NUM
eurjchem-2455	9	6	received	receive	VERB
eurjchem-2455	9	7	:	:	PUNCT
eurjchem-2455	9	8	27	27	NUM
eurjchem-2455	9	9	may	may	AUX
eurjchem-2455	9	10	2023	2023	NUM
eurjchem-2455	9	11	received	receive	VERB
eurjchem-2455	9	12	in	in	ADP
eurjchem-2455	9	13	revised	revise	VERB
eurjchem-2455	9	14	form	form	NOUN
eurjchem-2455	9	15	:	:	PUNCT
eurjchem-2455	9	16	17	17	NUM
eurjchem-2455	9	17	july	july	PROPN
eurjchem-2455	9	18	2023	2023	NUM
eurjchem-2455	9	19	accepted	accept	VERB
eurjchem-2455	9	20	:	:	PUNCT
eurjchem-2455	9	21	26	26	NUM
eurjchem-2455	9	22	july	july	PROPN
eurjchem-2455	9	23	2023	2023	NUM
eurjchem-2455	9	24	published	publish	VERB
eurjchem-2455	9	25	online	online	NOUN
eurjchem-2455	9	26	:	:	PUNCT
eurjchem-2455	9	27	30	30	NUM
eurjchem-2455	9	28	september	september	PROPN
eurjchem-2455	9	29	2023	2023	NUM
eurjchem-2455	9	30	printed	print	VERB
eurjchem-2455	9	31	:	:	PUNCT
eurjchem-2455	9	32	30	30	NUM
eurjchem-2455	9	33	september	september	PROPN
eurjchem-2455	9	34	2023	2023	NUM
eurjchem-2455	9	35	sickle	sickle	NOUN
eurjchem-2455	9	36	cell	cell	NOUN
eurjchem-2455	9	37	anemia	anemia	NOUN
eurjchem-2455	9	38	disease	disease	NOUN
eurjchem-2455	9	39	has	have	AUX
eurjchem-2455	9	40	been	be	AUX
eurjchem-2455	9	41	a	a	DET
eurjchem-2455	9	42	great	great	ADJ
eurjchem-2455	9	43	challenge	challenge	NOUN
eurjchem-2455	9	44	for	for	ADP
eurjchem-2455	9	45	the	the	DET
eurjchem-2455	9	46	world	world	NOUN
eurjchem-2455	9	47	in	in	ADP
eurjchem-2455	9	48	the	the	DET
eurjchem-2455	9	49	present	present	ADJ
eurjchem-2455	9	50	situation	situation	NOUN
eurjchem-2455	9	51	.	.	PUNCT
eurjchem-2455	10	1	it	it	PRON
eurjchem-2455	10	2	occurs	occur	VERB
eurjchem-2455	10	3	only	only	ADV
eurjchem-2455	10	4	due	due	ADP
eurjchem-2455	10	5	to	to	ADP
eurjchem-2455	10	6	the	the	DET
eurjchem-2455	10	7	polymerization	polymerization	NOUN
eurjchem-2455	10	8	of	of	ADP
eurjchem-2455	10	9	sickle	sickle	PROPN
eurjchem-2455	10	10	hemoglobin	hemoglobin	NOUN
eurjchem-2455	10	11	(	(	PUNCT
eurjchem-2455	10	12	hbs	hbs	PROPN
eurjchem-2455	10	13	)	)	PUNCT
eurjchem-2455	10	14	having	have	VERB
eurjchem-2455	10	15	pro	pro	ADJ
eurjchem-2455	10	16	-	-	ADJ
eurjchem-2455	10	17	val	val	ADJ
eurjchem-2455	10	18	-	-	PUNCT
eurjchem-2455	10	19	glu	glu	NOUN
eurjchem-2455	10	20	(	(	PUNCT
eurjchem-2455	10	21	pvg	pvg	PROPN
eurjchem-2455	10	22	)	)	PUNCT
eurjchem-2455	10	23	typed	type	VERB
eurjchem-2455	10	24	mutation	mutation	NOUN
eurjchem-2455	10	25	,	,	PUNCT
eurjchem-2455	10	26	while	while	SCONJ
eurjchem-2455	10	27	the	the	DET
eurjchem-2455	10	28	polymerization	polymerization	NOUN
eurjchem-2455	10	29	does	do	AUX
eurjchem-2455	10	30	not	not	PART
eurjchem-2455	10	31	occur	occur	VERB
eurjchem-2455	10	32	in	in	ADP
eurjchem-2455	10	33	normal	normal	ADJ
eurjchem-2455	10	34	hemoglobin	hemoglobin	NOUN
eurjchem-2455	10	35	(	(	PUNCT
eurjchem-2455	10	36	hba	hba	NOUN
eurjchem-2455	10	37	)	)	PUNCT
eurjchem-2455	10	38	having	have	VERB
eurjchem-2455	10	39	pro	pro	ADJ
eurjchem-2455	10	40	-	-	ADJ
eurjchem-2455	10	41	glu	glu	ADJ
eurjchem-2455	10	42	-	-	PUNCT
eurjchem-2455	10	43	glu	glu	NOUN
eurjchem-2455	10	44	(	(	PUNCT
eurjchem-2455	10	45	pgg	pgg	NOUN
eurjchem-2455	10	46	)	)	PUNCT
eurjchem-2455	10	47	residues	residue	NOUN
eurjchem-2455	10	48	.	.	PUNCT
eurjchem-2455	11	1	according	accord	VERB
eurjchem-2455	11	2	to	to	ADP
eurjchem-2455	11	3	data	datum	NOUN
eurjchem-2455	11	4	from	from	ADP
eurjchem-2455	11	5	the	the	DET
eurjchem-2455	11	6	literature	literature	NOUN
eurjchem-2455	11	7	,	,	PUNCT
eurjchem-2455	11	8	val	val	PROPN
eurjchem-2455	11	9	-	-	PUNCT
eurjchem-2455	11	10	beta6	beta6	NOUN
eurjchem-2455	11	11	of	of	ADP
eurjchem-2455	11	12	proval	proval	NOUN
eurjchem-2455	11	13	-	-	PUNCT
eurjchem-2455	11	14	glu	glu	NOUN
eurjchem-2455	11	15	is	be	AUX
eurjchem-2455	11	16	hydrophobic	hydrophobic	NOUN
eurjchem-2455	11	17	in	in	ADP
eurjchem-2455	11	18	nature	nature	NOUN
eurjchem-2455	11	19	,	,	PUNCT
eurjchem-2455	11	20	which	which	PRON
eurjchem-2455	11	21	appears	appear	VERB
eurjchem-2455	11	22	to	to	PART
eurjchem-2455	11	23	fit	fit	VERB
eurjchem-2455	11	24	into	into	ADP
eurjchem-2455	11	25	a	a	DET
eurjchem-2455	11	26	hydrophobic	hydrophobic	NOUN
eurjchem-2455	11	27	pocket	pocket	NOUN
eurjchem-2455	11	28	in	in	ADP
eurjchem-2455	11	29	the	the	DET
eurjchem-2455	11	30	adjacent	adjacent	ADJ
eurjchem-2455	11	31	hbs	hbs	PROPN
eurjchem-2455	11	32	.	.	PUNCT
eurjchem-2455	12	1	after	after	ADP
eurjchem-2455	12	2	the	the	DET
eurjchem-2455	12	3	insertion	insertion	NOUN
eurjchem-2455	12	4	of	of	ADP
eurjchem-2455	12	5	pro	pro	ADJ
eurjchem-2455	12	6	-	-	ADJ
eurjchem-2455	12	7	val	val	ADJ
eurjchem-2455	12	8	-	-	PUNCT
eurjchem-2455	12	9	glu	glu	NOUN
eurjchem-2455	12	10	into	into	ADP
eurjchem-2455	12	11	a	a	DET
eurjchem-2455	12	12	hydrophobic	hydrophobic	NOUN
eurjchem-2455	12	13	pocket	pocket	NOUN
eurjchem-2455	12	14	on	on	ADP
eurjchem-2455	12	15	the	the	DET
eurjchem-2455	12	16	adjacent	adjacent	ADJ
eurjchem-2455	12	17	hbs	hbs	PROPN
eurjchem-2455	12	18	,	,	PUNCT
eurjchem-2455	12	19	the	the	DET
eurjchem-2455	12	20	polymerization	polymerization	NOUN
eurjchem-2455	12	21	is	be	AUX
eurjchem-2455	12	22	started	start	VERB
eurjchem-2455	12	23	.	.	PUNCT
eurjchem-2455	13	1	this	this	PRON
eurjchem-2455	13	2	is	be	AUX
eurjchem-2455	13	3	a	a	DET
eurjchem-2455	13	4	questionable	questionable	ADJ
eurjchem-2455	13	5	point	point	NOUN
eurjchem-2455	13	6	on	on	ADP
eurjchem-2455	13	7	how	how	SCONJ
eurjchem-2455	13	8	the	the	DET
eurjchem-2455	13	9	replacement	replacement	NOUN
eurjchem-2455	13	10	of	of	ADP
eurjchem-2455	13	11	glutamic	glutamic	ADJ
eurjchem-2455	13	12	acid	acid	NOUN
eurjchem-2455	13	13	with	with	ADP
eurjchem-2455	13	14	valine	valine	NOUN
eurjchem-2455	13	15	in	in	ADP
eurjchem-2455	13	16	hbs	hbs	PROPN
eurjchem-2455	13	17	makes	make	VERB
eurjchem-2455	13	18	it	it	PRON
eurjchem-2455	13	19	more	more	ADV
eurjchem-2455	13	20	reactive	reactive	ADJ
eurjchem-2455	13	21	to	to	PART
eurjchem-2455	13	22	fit	fit	VERB
eurjchem-2455	13	23	into	into	ADP
eurjchem-2455	13	24	a	a	DET
eurjchem-2455	13	25	hydrophobic	hydrophobic	NOUN
eurjchem-2455	13	26	pocket	pocket	NOUN
eurjchem-2455	13	27	on	on	ADP
eurjchem-2455	13	28	adjacent	adjacent	ADJ
eurjchem-2455	13	29	hbs	hbs	PROPN
eurjchem-2455	13	30	for	for	ADP
eurjchem-2455	13	31	polymerization	polymerization	NOUN
eurjchem-2455	13	32	.	.	PUNCT
eurjchem-2455	14	1	no	no	DET
eurjchem-2455	14	2	data	datum	NOUN
eurjchem-2455	14	3	from	from	ADP
eurjchem-2455	14	4	the	the	DET
eurjchem-2455	14	5	literature	literature	NOUN
eurjchem-2455	14	6	on	on	ADP
eurjchem-2455	14	7	the	the	DET
eurjchem-2455	14	8	reactivity	reactivity	NOUN
eurjchem-2455	14	9	of	of	ADP
eurjchem-2455	14	10	hbs	hbs	PROPN
eurjchem-2455	14	11	for	for	ADP
eurjchem-2455	14	12	polymerization	polymerization	NOUN
eurjchem-2455	14	13	was	be	AUX
eurjchem-2455	14	14	found	find	VERB
eurjchem-2455	14	15	yet	yet	ADV
eurjchem-2455	14	16	.	.	PUNCT
eurjchem-2455	15	1	this	this	PRON
eurjchem-2455	15	2	is	be	AUX
eurjchem-2455	15	3	the	the	DET
eurjchem-2455	15	4	first	first	ADJ
eurjchem-2455	15	5	time	time	NOUN
eurjchem-2455	15	6	that	that	SCONJ
eurjchem-2455	15	7	the	the	DET
eurjchem-2455	15	8	theoretical	theoretical	ADJ
eurjchem-2455	15	9	calculation	calculation	NOUN
eurjchem-2455	15	10	was	be	AUX
eurjchem-2455	15	11	done	do	VERB
eurjchem-2455	15	12	in	in	ADP
eurjchem-2455	15	13	both	both	DET
eurjchem-2455	15	14	hba	hba	NOUN
eurjchem-2455	15	15	and	and	CCONJ
eurjchem-2455	15	16	hbs	hbs	PROPN
eurjchem-2455	15	17	where	where	SCONJ
eurjchem-2455	15	18	they	they	PRON
eurjchem-2455	15	19	were	be	AUX
eurjchem-2455	15	20	structurally	structurally	ADV
eurjchem-2455	15	21	different	different	ADJ
eurjchem-2455	15	22	.	.	PUNCT
eurjchem-2455	16	1	after	after	ADP
eurjchem-2455	16	2	that	that	PRON
eurjchem-2455	16	3	,	,	PUNCT
eurjchem-2455	16	4	a	a	DET
eurjchem-2455	16	5	comparative	comparative	ADJ
eurjchem-2455	16	6	study	study	NOUN
eurjchem-2455	16	7	between	between	ADP
eurjchem-2455	16	8	pvg	pvg	PROPN
eurjchem-2455	16	9	and	and	CCONJ
eurjchem-2455	16	10	pgg	pgg	NOUN
eurjchem-2455	16	11	was	be	AUX
eurjchem-2455	16	12	done	do	VERB
eurjchem-2455	16	13	at	at	ADP
eurjchem-2455	16	14	quantum	quantum	ADJ
eurjchem-2455	16	15	level	level	NOUN
eurjchem-2455	16	16	for	for	ADP
eurjchem-2455	16	17	the	the	DET
eurjchem-2455	16	18	evaluation	evaluation	NOUN
eurjchem-2455	16	19	of	of	ADP
eurjchem-2455	16	20	the	the	DET
eurjchem-2455	16	21	reactivity	reactivity	NOUN
eurjchem-2455	16	22	to	to	PART
eurjchem-2455	16	23	fit	fit	VERB
eurjchem-2455	16	24	into	into	ADP
eurjchem-2455	16	25	a	a	DET
eurjchem-2455	16	26	hydrophobic	hydrophobic	NOUN
eurjchem-2455	16	27	pocket	pocket	NOUN
eurjchem-2455	16	28	on	on	ADP
eurjchem-2455	16	29	adjacent	adjacent	ADJ
eurjchem-2455	16	30	hbs	hbs	PROPN
eurjchem-2455	16	31	.	.	PUNCT
eurjchem-2455	17	1	at	at	ADP
eurjchem-2455	17	2	a	a	DET
eurjchem-2455	17	3	quantum	quantum	ADJ
eurjchem-2455	17	4	level	level	NOUN
eurjchem-2455	17	5	,	,	PUNCT
eurjchem-2455	17	6	it	it	PRON
eurjchem-2455	17	7	was	be	AUX
eurjchem-2455	17	8	found	find	VERB
eurjchem-2455	17	9	that	that	SCONJ
eurjchem-2455	17	10	the	the	DET
eurjchem-2455	17	11	homolumo	homolumo	ADJ
eurjchem-2455	17	12	gap	gap	NOUN
eurjchem-2455	17	13	of	of	ADP
eurjchem-2455	17	14	pro	pro	ADJ
eurjchem-2455	17	15	-	-	ADJ
eurjchem-2455	17	16	val	val	ADJ
eurjchem-2455	17	17	-	-	PUNCT
eurjchem-2455	17	18	glu	glu	NOUN
eurjchem-2455	17	19	was	be	AUX
eurjchem-2455	17	20	lower	low	ADJ
eurjchem-2455	17	21	than	than	ADP
eurjchem-2455	17	22	that	that	PRON
eurjchem-2455	17	23	of	of	ADP
eurjchem-2455	17	24	pro	pro	ADJ
eurjchem-2455	17	25	-	-	ADJ
eurjchem-2455	17	26	glu	glu	ADJ
eurjchem-2455	17	27	-	-	PUNCT
eurjchem-2455	17	28	glu	glu	NOUN
eurjchem-2455	17	29	.	.	PUNCT
eurjchem-2455	18	1	according	accord	VERB
eurjchem-2455	18	2	to	to	ADP
eurjchem-2455	18	3	the	the	DET
eurjchem-2455	18	4	data	datum	NOUN
eurjchem-2455	18	5	from	from	ADP
eurjchem-2455	18	6	the	the	DET
eurjchem-2455	18	7	literature	literature	NOUN
eurjchem-2455	18	8	,	,	PUNCT
eurjchem-2455	18	9	the	the	DET
eurjchem-2455	18	10	lesser	less	ADJ
eurjchem-2455	18	11	homo	homo	NOUN
eurjchem-2455	18	12	-	-	PUNCT
eurjchem-2455	18	13	lumo	lumo	NOUN
eurjchem-2455	18	14	gap	gap	NOUN
eurjchem-2455	18	15	promotes	promote	VERB
eurjchem-2455	18	16	the	the	DET
eurjchem-2455	18	17	initiation	initiation	NOUN
eurjchem-2455	18	18	of	of	ADP
eurjchem-2455	18	19	the	the	DET
eurjchem-2455	18	20	polymerization	polymerization	NOUN
eurjchem-2455	18	21	reaction	reaction	NOUN
eurjchem-2455	18	22	.	.	PUNCT
eurjchem-2455	19	1	on	on	ADP
eurjchem-2455	19	2	the	the	DET
eurjchem-2455	19	3	basis	basis	NOUN
eurjchem-2455	19	4	of	of	ADP
eurjchem-2455	19	5	the	the	DET
eurjchem-2455	19	6	results	result	NOUN
eurjchem-2455	19	7	,	,	PUNCT
eurjchem-2455	19	8	it	it	PRON
eurjchem-2455	19	9	was	be	AUX
eurjchem-2455	19	10	also	also	ADV
eurjchem-2455	19	11	shown	show	VERB
eurjchem-2455	19	12	how	how	SCONJ
eurjchem-2455	19	13	the	the	DET
eurjchem-2455	19	14	mutation	mutation	NOUN
eurjchem-2455	19	15	point	point	NOUN
eurjchem-2455	19	16	(	(	PUNCT
eurjchem-2455	19	17	pro	pro	ADJ
eurjchem-2455	19	18	-	-	ADJ
eurjchem-2455	19	19	val	val	ADJ
eurjchem-2455	19	20	-	-	PUNCT
eurjchem-2455	19	21	glu	glu	NOUN
eurjchem-2455	19	22	)	)	PUNCT
eurjchem-2455	19	23	in	in	ADP
eurjchem-2455	19	24	hbs	hbs	PROPN
eurjchem-2455	19	25	becomes	become	VERB
eurjchem-2455	19	26	more	more	ADV
eurjchem-2455	19	27	reactive	reactive	ADJ
eurjchem-2455	19	28	to	to	ADP
eurjchem-2455	19	29	polymerization	polymerization	NOUN
eurjchem-2455	19	30	,	,	PUNCT
eurjchem-2455	19	31	whereas	whereas	SCONJ
eurjchem-2455	19	32	pro	pro	ADJ
eurjchem-2455	19	33	-	-	ADJ
eurjchem-2455	19	34	glu	glu	ADJ
eurjchem-2455	19	35	-	-	PUNCT
eurjchem-2455	19	36	glu	glu	NOUN
eurjchem-2455	19	37	in	in	ADP
eurjchem-2455	19	38	hba	hba	NOUN
eurjchem-2455	19	39	does	do	VERB
eurjchem-2455	19	40	not	not	PART
eurjchem-2455	19	41	.	.	PUNCT
eurjchem-2455	20	1	the	the	DET
eurjchem-2455	20	2	computational	computational	ADJ
eurjchem-2455	20	3	method	method	NOUN
eurjchem-2455	20	4	developed	develop	VERB
eurjchem-2455	20	5	for	for	ADP
eurjchem-2455	20	6	the	the	DET
eurjchem-2455	20	7	first	first	ADJ
eurjchem-2455	20	8	time	time	NOUN
eurjchem-2455	20	9	will	will	AUX
eurjchem-2455	20	10	be	be	AUX
eurjchem-2455	20	11	very	very	ADV
eurjchem-2455	20	12	helpful	helpful	ADJ
eurjchem-2455	20	13	not	not	PART
eurjchem-2455	20	14	only	only	ADV
eurjchem-2455	20	15	for	for	ADP
eurjchem-2455	20	16	molecular	molecular	ADJ
eurjchem-2455	20	17	biologists	biologist	NOUN
eurjchem-2455	20	18	but	but	CCONJ
eurjchem-2455	20	19	also	also	ADV
eurjchem-2455	20	20	for	for	ADP
eurjchem-2455	20	21	computational	computational	ADJ
eurjchem-2455	20	22	and	and	CCONJ
eurjchem-2455	20	23	medicinal	medicinal	ADJ
eurjchem-2455	20	24	chemists	chemist	NOUN
eurjchem-2455	20	25	.	.	PUNCT
eurjchem-2455	21	1	additionally	additionally	ADV
eurjchem-2455	21	2	,	,	PUNCT
eurjchem-2455	21	3	the	the	DET
eurjchem-2455	21	4	required	require	VERB
eurjchem-2455	21	5	modifications	modification	NOUN
eurjchem-2455	21	6	based	base	VERB
eurjchem-2455	21	7	on	on	ADP
eurjchem-2455	21	8	gaps	gap	NOUN
eurjchem-2455	21	9	in	in	ADP
eurjchem-2455	21	10	anti	anti	ADJ
eurjchem-2455	21	11	-	-	ADJ
eurjchem-2455	21	12	sickling	sickling	ADJ
eurjchem-2455	21	13	drug	drug	NOUN
eurjchem-2455	21	14	development	development	NOUN
eurjchem-2455	21	15	are	be	AUX
eurjchem-2455	21	16	also	also	ADV
eurjchem-2455	21	17	suggested	suggest	VERB
eurjchem-2455	21	18	in	in	ADP
eurjchem-2455	21	19	the	the	DET
eurjchem-2455	21	20	presented	present	VERB
eurjchem-2455	21	21	article	article	NOUN
eurjchem-2455	21	22	.	.	PUNCT
eurjchem-2455	22	1	mutation	mutation	NOUN
eurjchem-2455	22	2	polymerization	polymerization	NOUN
eurjchem-2455	22	3	sickle	sickle	NOUN
eurjchem-2455	22	4	cell	cell	NOUN
eurjchem-2455	22	5	anemia	anemia	NOUN
eurjchem-2455	22	6	homo	homo	NOUN
eurjchem-2455	22	7	-	-	PUNCT
eurjchem-2455	22	8	lumo	lumo	NOUN
eurjchem-2455	22	9	gap	gap	NOUN
eurjchem-2455	22	10	theoretical	theoretical	ADJ
eurjchem-2455	22	11	calculation	calculation	NOUN
eurjchem-2455	22	12	drug	drug	NOUN
eurjchem-2455	22	13	development	development	NOUN
eurjchem-2455	22	14	and	and	CCONJ
eurjchem-2455	22	15	gaps	gap	NOUN
eurjchem-2455	22	16	cite	cite	VERB
eurjchem-2455	22	17	this	this	PRON
eurjchem-2455	22	18	:	:	PUNCT
eurjchem-2455	22	19	eur	eur	PROPN
eurjchem-2455	22	20	.	.	PUNCT
eurjchem-2455	23	1	j.	j.	PROPN
eurjchem-2455	23	2	chem	chem	PROPN
eurjchem-2455	23	3	.	.	PUNCT
eurjchem-2455	24	1	2023	2023	NUM
eurjchem-2455	24	2	,	,	PUNCT
eurjchem-2455	24	3	14(3	14(3	NUM
eurjchem-2455	24	4	)	)	PUNCT
eurjchem-2455	24	5	,	,	PUNCT
eurjchem-2455	24	6	370	370	NUM
eurjchem-2455	24	7	-	-	SYM
eurjchem-2455	24	8	375	375	NUM
eurjchem-2455	24	9	journal	journal	NOUN
eurjchem-2455	24	10	website	website	NOUN
eurjchem-2455	24	11	:	:	PUNCT
eurjchem-2455	24	12	www.eurjchem.com	www.eurjchem.com	X
eurjchem-2455	24	13	1	1	X
eurjchem-2455	24	14	.	.	PUNCT
eurjchem-2455	24	15	introduction	introduction	NOUN
eurjchem-2455	24	16	of	of	ADP
eurjchem-2455	24	17	course	course	NOUN
eurjchem-2455	24	18	,	,	PUNCT
eurjchem-2455	24	19	sickle	sickle	NOUN
eurjchem-2455	24	20	cell	cell	NOUN
eurjchem-2455	24	21	anemia	anemia	NOUN
eurjchem-2455	24	22	disease	disease	NOUN
eurjchem-2455	24	23	(	(	PUNCT
eurjchem-2455	24	24	scad	scad	NOUN
eurjchem-2455	24	25	)	)	PUNCT
eurjchem-2455	24	26	has	have	AUX
eurjchem-2455	24	27	been	be	AUX
eurjchem-2455	24	28	a	a	DET
eurjchem-2455	24	29	very	very	ADV
eurjchem-2455	24	30	old	old	ADJ
eurjchem-2455	24	31	one	one	NUM
eurjchem-2455	24	32	.	.	PUNCT
eurjchem-2455	25	1	therefore	therefore	ADV
eurjchem-2455	25	2	,	,	PUNCT
eurjchem-2455	25	3	many	many	ADJ
eurjchem-2455	25	4	studies	study	NOUN
eurjchem-2455	25	5	have	have	AUX
eurjchem-2455	25	6	been	be	AUX
eurjchem-2455	25	7	done	do	VERB
eurjchem-2455	25	8	to	to	PART
eurjchem-2455	25	9	evaluate	evaluate	VERB
eurjchem-2455	25	10	this	this	DET
eurjchem-2455	25	11	disease	disease	NOUN
eurjchem-2455	25	12	,	,	PUNCT
eurjchem-2455	25	13	but	but	CCONJ
eurjchem-2455	25	14	pauling	paule	VERB
eurjchem-2455	26	1	[	[	X
eurjchem-2455	26	2	1	1	X
eurjchem-2455	26	3	]	]	PUNCT
eurjchem-2455	26	4	noted	note	VERB
eurjchem-2455	26	5	the	the	DET
eurjchem-2455	26	6	main	main	ADJ
eurjchem-2455	26	7	point	point	NOUN
eurjchem-2455	26	8	for	for	ADP
eurjchem-2455	26	9	the	the	DET
eurjchem-2455	26	10	first	first	ADJ
eurjchem-2455	26	11	time	time	NOUN
eurjchem-2455	26	12	when	when	SCONJ
eurjchem-2455	26	13	he	he	PRON
eurjchem-2455	26	14	found	find	VERB
eurjchem-2455	26	15	that	that	SCONJ
eurjchem-2455	26	16	sickle	sickle	NOUN
eurjchem-2455	26	17	cell	cell	NOUN
eurjchem-2455	26	18	anemia	anemia	NOUN
eurjchem-2455	26	19	is	be	AUX
eurjchem-2455	26	20	a	a	DET
eurjchem-2455	26	21	molecular	molecular	ADJ
eurjchem-2455	26	22	disease	disease	NOUN
eurjchem-2455	26	23	.	.	PUNCT
eurjchem-2455	27	1	subsequently	subsequently	ADV
eurjchem-2455	27	2	,	,	PUNCT
eurjchem-2455	27	3	ingram	ingram	PROPN
eurjchem-2455	28	1	[	[	X
eurjchem-2455	28	2	2	2	NUM
eurjchem-2455	28	3	]	]	PUNCT
eurjchem-2455	28	4	studied	study	VERB
eurjchem-2455	28	5	the	the	DET
eurjchem-2455	28	6	structures	structure	NOUN
eurjchem-2455	28	7	of	of	ADP
eurjchem-2455	28	8	sickle	sickle	NOUN
eurjchem-2455	28	9	hemoglobin	hemoglobin	NOUN
eurjchem-2455	28	10	(	(	PUNCT
eurjchem-2455	28	11	hbs	hbs	PROPN
eurjchem-2455	28	12	)	)	PUNCT
eurjchem-2455	28	13	and	and	CCONJ
eurjchem-2455	28	14	normal	normal	ADJ
eurjchem-2455	28	15	hemoglobin	hemoglobin	NOUN
eurjchem-2455	28	16	(	(	PUNCT
eurjchem-2455	28	17	hba	hba	NOUN
eurjchem-2455	28	18	)	)	PUNCT
eurjchem-2455	28	19	to	to	PART
eurjchem-2455	28	20	confirm	confirm	VERB
eurjchem-2455	28	21	the	the	DET
eurjchem-2455	28	22	exact	exact	ADJ
eurjchem-2455	28	23	change	change	NOUN
eurjchem-2455	28	24	at	at	ADP
eurjchem-2455	28	25	the	the	DET
eurjchem-2455	28	26	gene	gene	NOUN
eurjchem-2455	28	27	mutation	mutation	NOUN
eurjchem-2455	28	28	point	point	NOUN
eurjchem-2455	28	29	.	.	PUNCT
eurjchem-2455	29	1	he	he	PRON
eurjchem-2455	29	2	reported	report	VERB
eurjchem-2455	29	3	[	[	X
eurjchem-2455	29	4	2	2	X
eurjchem-2455	29	5	]	]	PUNCT
eurjchem-2455	29	6	that	that	SCONJ
eurjchem-2455	29	7	one	one	NUM
eurjchem-2455	29	8	of	of	ADP
eurjchem-2455	29	9	the	the	DET
eurjchem-2455	29	10	glutamic	glutamic	ADJ
eurjchem-2455	29	11	acid	acid	NOUN
eurjchem-2455	29	12	residues	residue	NOUN
eurjchem-2455	29	13	of	of	ADP
eurjchem-2455	29	14	pro	pro	ADJ
eurjchem-2455	29	15	-	-	ADJ
eurjchem-2455	29	16	gluglu	gluglu	ADJ
eurjchem-2455	29	17	(	(	PUNCT
eurjchem-2455	29	18	pgg	pgg	NOUN
eurjchem-2455	29	19	)	)	PUNCT
eurjchem-2455	29	20	present	present	ADJ
eurjchem-2455	29	21	in	in	ADP
eurjchem-2455	29	22	normal	normal	ADJ
eurjchem-2455	29	23	hemoglobin	hemoglobin	NOUN
eurjchem-2455	29	24	(	(	PUNCT
eurjchem-2455	29	25	hba	hba	NOUN
eurjchem-2455	29	26	)	)	PUNCT
eurjchem-2455	29	27	,	,	PUNCT
eurjchem-2455	29	28	is	be	AUX
eurjchem-2455	29	29	replaced	replace	VERB
eurjchem-2455	29	30	by	by	ADP
eurjchem-2455	29	31	the	the	DET
eurjchem-2455	29	32	valine	valine	NOUN
eurjchem-2455	29	33	residue	residue	NOUN
eurjchem-2455	29	34	,	,	PUNCT
eurjchem-2455	29	35	that	that	ADV
eurjchem-2455	29	36	is	is	ADV
eurjchem-2455	29	37	,	,	PUNCT
eurjchem-2455	29	38	pro	pro	ADJ
eurjchem-2455	29	39	-	-	ADJ
eurjchem-2455	29	40	val	val	ADJ
eurjchem-2455	29	41	-	-	PUNCT
eurjchem-2455	29	42	glu	glu	NOUN
eurjchem-2455	29	43	(	(	PUNCT
eurjchem-2455	29	44	pvg	pvg	PROPN
eurjchem-2455	29	45	)	)	PUNCT
eurjchem-2455	29	46	in	in	ADP
eurjchem-2455	29	47	sickle	sickle	NOUN
eurjchem-2455	29	48	cell	cell	NOUN
eurjchem-2455	29	49	,	,	PUNCT
eurjchem-2455	29	50	also	also	ADV
eurjchem-2455	29	51	called	call	VERB
eurjchem-2455	29	52	the	the	DET
eurjchem-2455	29	53	e6v	e6v	PROPN
eurjchem-2455	29	54	mutation	mutation	NOUN
eurjchem-2455	29	55	.	.	PUNCT
eurjchem-2455	30	1	although	although	SCONJ
eurjchem-2455	30	2	sickle	sickle	NOUN
eurjchem-2455	30	3	hemoglobin	hemoglobin	NOUN
eurjchem-2455	30	4	(	(	PUNCT
eurjchem-2455	30	5	hbs	hbs	PROPN
eurjchem-2455	30	6	)	)	PUNCT
eurjchem-2455	30	7	has	have	VERB
eurjchem-2455	30	8	normal	normal	ADJ
eurjchem-2455	30	9	oxygen	oxygen	NOUN
eurjchem-2455	30	10	binding	bind	VERB
eurjchem-2455	30	11	affinity	affinity	NOUN
eurjchem-2455	30	12	,	,	PUNCT
eurjchem-2455	30	13	its	its	PRON
eurjchem-2455	30	14	polymerized	polymerized	ADJ
eurjchem-2455	30	15	form	form	NOUN
eurjchem-2455	30	16	does	do	AUX
eurjchem-2455	30	17	not	not	PART
eurjchem-2455	30	18	[	[	X
eurjchem-2455	30	19	3	3	NUM
eurjchem-2455	30	20	]	]	PUNCT
eurjchem-2455	30	21	.	.	PUNCT
eurjchem-2455	31	1	the	the	DET
eurjchem-2455	31	2	low	low	ADJ
eurjchem-2455	31	3	affinity	affinity	NOUN
eurjchem-2455	31	4	of	of	ADP
eurjchem-2455	31	5	a	a	DET
eurjchem-2455	31	6	hemoglobin	hemoglobin	NOUN
eurjchem-2455	31	7	mutant	mutant	NOUN
eurjchem-2455	31	8	is	be	AUX
eurjchem-2455	31	9	a	a	DET
eurjchem-2455	31	10	characteristic	characteristic	NOUN
eurjchem-2455	31	11	of	of	ADP
eurjchem-2455	31	12	sickle	sickle	NOUN
eurjchem-2455	31	13	cell	cell	NOUN
eurjchem-2455	31	14	anemia	anemia	NOUN
eurjchem-2455	31	15	disease	disease	NOUN
eurjchem-2455	31	16	that	that	PRON
eurjchem-2455	31	17	was	be	AUX
eurjchem-2455	31	18	confirmed	confirm	VERB
eurjchem-2455	31	19	in	in	ADP
eurjchem-2455	31	20	detail	detail	NOUN
eurjchem-2455	31	21	more	more	ADV
eurjchem-2455	31	22	recently	recently	ADV
eurjchem-2455	31	23	[	[	X
eurjchem-2455	31	24	4	4	NUM
eurjchem-2455	31	25	]	]	PUNCT
eurjchem-2455	31	26	.	.	PUNCT
eurjchem-2455	32	1	the	the	DET
eurjchem-2455	32	2	production	production	NOUN
eurjchem-2455	32	3	of	of	ADP
eurjchem-2455	32	4	abnormal	abnormal	ADJ
eurjchem-2455	32	5	red	red	ADJ
eurjchem-2455	32	6	blood	blood	NOUN
eurjchem-2455	32	7	cells	cell	NOUN
eurjchem-2455	32	8	(	(	PUNCT
eurjchem-2455	32	9	rbcs	rbc	NOUN
eurjchem-2455	32	10	)	)	PUNCT
eurjchem-2455	32	11	is	be	AUX
eurjchem-2455	32	12	also	also	ADV
eurjchem-2455	32	13	associated	associate	VERB
eurjchem-2455	32	14	with	with	ADP
eurjchem-2455	32	15	the	the	DET
eurjchem-2455	32	16	polymerization	polymerization	NOUN
eurjchem-2455	32	17	that	that	PRON
eurjchem-2455	32	18	occurs	occur	VERB
eurjchem-2455	32	19	under	under	ADP
eurjchem-2455	32	20	hypoxic	hypoxic	ADJ
eurjchem-2455	32	21	conditions	condition	NOUN
eurjchem-2455	32	22	[	[	X
eurjchem-2455	32	23	3,5	3,5	NUM
eurjchem-2455	32	24	]	]	PUNCT
eurjchem-2455	32	25	,	,	PUNCT
eurjchem-2455	32	26	that	that	ADV
eurjchem-2455	32	27	is	is	ADV
eurjchem-2455	32	28	,	,	PUNCT
eurjchem-2455	32	29	a	a	DET
eurjchem-2455	32	30	low	low	ADJ
eurjchem-2455	32	31	concentration	concentration	NOUN
eurjchem-2455	32	32	of	of	ADP
eurjchem-2455	32	33	oxygen	oxygen	NOUN
eurjchem-2455	32	34	.	.	PUNCT
eurjchem-2455	33	1	gill	gill	PROPN
eurjchem-2455	33	2	et	et	PROPN
eurjchem-2455	33	3	al	al	PROPN
eurjchem-2455	33	4	.	.	PUNCT
eurjchem-2455	34	1	[	[	X
eurjchem-2455	34	2	6	6	NUM
eurjchem-2455	34	3	]	]	PUNCT
eurjchem-2455	34	4	showed	show	VERB
eurjchem-2455	34	5	a	a	DET
eurjchem-2455	34	6	sharp	sharp	ADJ
eurjchem-2455	34	7	decrease	decrease	NOUN
eurjchem-2455	34	8	in	in	ADP
eurjchem-2455	34	9	oxygen	oxygen	NOUN
eurjchem-2455	34	10	affinity	affinity	NOUN
eurjchem-2455	34	11	just	just	ADV
eurjchem-2455	34	12	after	after	ADP
eurjchem-2455	34	13	partial	partial	ADJ
eurjchem-2455	34	14	deoxygenation	deoxygenation	NOUN
eurjchem-2455	34	15	.	.	PUNCT
eurjchem-2455	35	1	it	it	PRON
eurjchem-2455	35	2	proved	prove	VERB
eurjchem-2455	35	3	that	that	SCONJ
eurjchem-2455	35	4	the	the	DET
eurjchem-2455	35	5	deoxygenated	deoxygenate	VERB
eurjchem-2455	35	6	form	form	NOUN
eurjchem-2455	35	7	of	of	ADP
eurjchem-2455	35	8	hbs	hbs	PROPN
eurjchem-2455	35	9	(	(	PUNCT
eurjchem-2455	35	10	dhbs	dhbs	PROPN
eurjchem-2455	35	11	)	)	PUNCT
eurjchem-2455	35	12	takes	take	VERB
eurjchem-2455	35	13	part	part	NOUN
eurjchem-2455	35	14	in	in	ADP
eurjchem-2455	35	15	the	the	DET
eurjchem-2455	35	16	polymerization	polymerization	NOUN
eurjchem-2455	35	17	reaction	reaction	NOUN
eurjchem-2455	35	18	rapidly	rapidly	ADV
eurjchem-2455	35	19	while	while	SCONJ
eurjchem-2455	35	20	the	the	DET
eurjchem-2455	35	21	oxygenated	oxygenated	ADJ
eurjchem-2455	35	22	form	form	NOUN
eurjchem-2455	35	23	(	(	PUNCT
eurjchem-2455	35	24	ohbs	ohbs	ADJ
eurjchem-2455	35	25	)	)	PUNCT
eurjchem-2455	35	26	does	do	VERB
eurjchem-2455	35	27	not	not	PART
eurjchem-2455	35	28	.	.	PUNCT
eurjchem-2455	36	1	therefore	therefore	ADV
eurjchem-2455	36	2	,	,	PUNCT
eurjchem-2455	36	3	abnormal	abnormal	ADJ
eurjchem-2455	36	4	rbc	rbc	PROPN
eurjchem-2455	36	5	production	production	NOUN
eurjchem-2455	36	6	is	be	AUX
eurjchem-2455	36	7	caused	cause	VERB
eurjchem-2455	36	8	by	by	ADP
eurjchem-2455	36	9	the	the	DET
eurjchem-2455	36	10	polymerization	polymerization	NOUN
eurjchem-2455	36	11	of	of	ADP
eurjchem-2455	36	12	deoxygenated	deoxygenate	VERB
eurjchem-2455	36	13	sickle	sickle	NOUN
eurjchem-2455	36	14	hemoglobin	hemoglobin	NOUN
eurjchem-2455	36	15	under	under	ADP
eurjchem-2455	36	16	hypoxic	hypoxic	ADJ
eurjchem-2455	36	17	conditions	condition	NOUN
eurjchem-2455	36	18	.	.	PUNCT
eurjchem-2455	37	1	different	different	ADJ
eurjchem-2455	37	2	studies	study	NOUN
eurjchem-2455	37	3	were	be	AUX
eurjchem-2455	37	4	done	do	VERB
eurjchem-2455	37	5	to	to	PART
eurjchem-2455	37	6	understand	understand	VERB
eurjchem-2455	37	7	the	the	DET
eurjchem-2455	37	8	effect	effect	NOUN
eurjchem-2455	37	9	of	of	ADP
eurjchem-2455	37	10	ph	ph	ADJ
eurjchem-2455	37	11	,	,	PUNCT
eurjchem-2455	37	12	carbon	carbon	NOUN
eurjchem-2455	37	13	monoxide	monoxide	NOUN
eurjchem-2455	37	14	,	,	PUNCT
eurjchem-2455	37	15	and	and	CCONJ
eurjchem-2455	37	16	other	other	ADJ
eurjchem-2455	37	17	factors	factor	NOUN
eurjchem-2455	37	18	on	on	ADP
eurjchem-2455	37	19	polymerization	polymerization	NOUN
eurjchem-2455	37	20	.	.	PUNCT
eurjchem-2455	38	1	for	for	ADP
eurjchem-2455	38	2	example	example	NOUN
eurjchem-2455	38	3	,	,	PUNCT
eurjchem-2455	38	4	the	the	DET
eurjchem-2455	38	5	findings	finding	NOUN
eurjchem-2455	38	6	regarding	regard	VERB
eurjchem-2455	38	7	the	the	DET
eurjchem-2455	38	8	ph	ph	ADJ
eurjchem-2455	38	9	effect	effect	NOUN
eurjchem-2455	38	10	showed	show	VERB
eurjchem-2455	38	11	that	that	SCONJ
eurjchem-2455	38	12	lowered	lower	VERB
eurjchem-2455	38	13	ph	ph	NOUN
eurjchem-2455	38	14	over	over	ADP
eurjchem-2455	38	15	the	the	DET
eurjchem-2455	38	16	physiological	physiological	ADJ
eurjchem-2455	38	17	range	range	NOUN
eurjchem-2455	38	18	promotes	promote	VERB
eurjchem-2455	38	19	the	the	DET
eurjchem-2455	38	20	polymerization	polymerization	NOUN
eurjchem-2455	38	21	of	of	ADP
eurjchem-2455	38	22	hbs	hbs	PROPN
eurjchem-2455	38	23	,	,	PUNCT
eurjchem-2455	38	24	and	and	CCONJ
eurjchem-2455	38	25	it	it	PRON
eurjchem-2455	38	26	causes	cause	VERB
eurjchem-2455	38	27	sickling	sickle	VERB
eurjchem-2455	38	28	of	of	ADP
eurjchem-2455	38	29	red	red	ADJ
eurjchem-2455	38	30	cells	cell	NOUN
eurjchem-2455	38	31	[	[	X
eurjchem-2455	38	32	7	7	NUM
eurjchem-2455	38	33	]	]	PUNCT
eurjchem-2455	38	34	,	,	PUNCT
eurjchem-2455	38	35	but	but	CCONJ
eurjchem-2455	38	36	it	it	PRON
eurjchem-2455	38	37	was	be	AUX
eurjchem-2455	38	38	shown	show	VERB
eurjchem-2455	38	39	that	that	SCONJ
eurjchem-2455	38	40	none	none	NOUN
eurjchem-2455	38	41	of	of	ADP
eurjchem-2455	38	42	these	these	DET
eurjchem-2455	38	43	factors	factor	NOUN
eurjchem-2455	38	44	could	could	AUX
eurjchem-2455	38	45	be	be	AUX
eurjchem-2455	38	46	responsible	responsible	ADJ
eurjchem-2455	38	47	for	for	ADP
eurjchem-2455	38	48	the	the	DET
eurjchem-2455	38	49	different	different	ADJ
eurjchem-2455	38	50	behavior	behavior	NOUN
eurjchem-2455	38	51	of	of	ADP
eurjchem-2455	38	52	sickle	sickle	NOUN
eurjchem-2455	38	53	cell	cell	NOUN
eurjchem-2455	38	54	disease	disease	NOUN
eurjchem-2455	38	55	under	under	ADP
eurjchem-2455	38	56	hypoxic	hypoxic	ADJ
eurjchem-2455	38	57	conditions	condition	NOUN
eurjchem-2455	38	58	[	[	X
eurjchem-2455	38	59	8	8	NUM
eurjchem-2455	38	60	]	]	PUNCT
eurjchem-2455	38	61	.	.	PUNCT
eurjchem-2455	39	1	hence	hence	ADV
eurjchem-2455	39	2	,	,	PUNCT
eurjchem-2455	39	3	the	the	DET
eurjchem-2455	39	4	truth	truth	NOUN
eurjchem-2455	39	5	behind	behind	ADP
eurjchem-2455	39	6	the	the	DET
eurjchem-2455	39	7	actual	actual	ADJ
eurjchem-2455	39	8	reason	reason	NOUN
eurjchem-2455	39	9	for	for	ADP
eurjchem-2455	39	10	the	the	DET
eurjchem-2455	39	11	hbs	hbs	PROPN
eurjchem-2455	39	12	polymerization	polymerization	NOUN
eurjchem-2455	39	13	is	be	AUX
eurjchem-2455	39	14	yet	yet	ADV
eurjchem-2455	39	15	to	to	PART
eurjchem-2455	39	16	come	come	VERB
eurjchem-2455	39	17	.	.	PUNCT
eurjchem-2455	40	1	the	the	DET
eurjchem-2455	40	2	normal	normal	ADJ
eurjchem-2455	40	3	pro	pro	ADJ
eurjchem-2455	40	4	-	-	ADJ
eurjchem-2455	40	5	glu	glu	ADJ
eurjchem-2455	40	6	-	-	PUNCT
eurjchem-2455	40	7	glu	glu	NOUN
eurjchem-2455	40	8	link	link	NOUN
eurjchem-2455	40	9	in	in	ADP
eurjchem-2455	40	10	hba	hba	NOUN
eurjchem-2455	40	11	is	be	AUX
eurjchem-2455	40	12	hydrophilic	hydrophilic	ADJ
eurjchem-2455	40	13	in	in	ADP
eurjchem-2455	40	14	nature	nature	NOUN
eurjchem-2455	40	15	,	,	PUNCT
eurjchem-2455	40	16	while	while	SCONJ
eurjchem-2455	40	17	pro	pro	ADJ
eurjchem-2455	40	18	-	-	ADJ
eurjchem-2455	40	19	val	val	ADJ
eurjchem-2455	40	20	-	-	PUNCT
eurjchem-2455	40	21	glu	glu	NOUN
eurjchem-2455	40	22	is	be	AUX
eurjchem-2455	40	23	a	a	DET
eurjchem-2455	40	24	hydrophobic	hydrophobic	NOUN
eurjchem-2455	40	25	link	link	NOUN
eurjchem-2455	40	26	in	in	ADP
eurjchem-2455	40	27	hbs	hbs	PROPN
eurjchem-2455	40	28	due	due	ADP
eurjchem-2455	40	29	to	to	ADP
eurjchem-2455	40	30	the	the	DET
eurjchem-2455	40	31	presence	presence	NOUN
eurjchem-2455	40	32	of	of	ADP
eurjchem-2455	40	33	a	a	DET
eurjchem-2455	40	34	hydrophobic	hydrophobic	NOUN
eurjchem-2455	40	35	valine	valine	NOUN
eurjchem-2455	40	36	residue	residue	NOUN
eurjchem-2455	41	1	[	[	PUNCT
eurjchem-2455	41	2	7	7	NUM
eurjchem-2455	41	3	-	-	SYM
eurjchem-2455	41	4	9	9	NUM
eurjchem-2455	41	5	]	]	PUNCT
eurjchem-2455	41	6	.	.	PUNCT
eurjchem-2455	42	1	therefore	therefore	ADV
eurjchem-2455	42	2	,	,	PUNCT
eurjchem-2455	42	3	researchers	researcher	NOUN
eurjchem-2455	42	4	[	[	X
eurjchem-2455	42	5	7	7	NUM
eurjchem-2455	42	6	-	-	SYM
eurjchem-2455	42	7	9	9	NUM
eurjchem-2455	42	8	]	]	PUNCT
eurjchem-2455	42	9	have	have	AUX
eurjchem-2455	42	10	suggested	suggest	VERB
eurjchem-2455	42	11	that	that	SCONJ
eurjchem-2455	42	12	the	the	DET
eurjchem-2455	42	13	hydrophobic	hydrophobic	NOUN
eurjchem-2455	42	14	r	r	NOUN
eurjchem-2455	42	15	-	-	PUNCT
eurjchem-2455	42	16	group	group	NOUN
eurjchem-2455	42	17	of	of	ADP
eurjchem-2455	42	18	val	val	PROPN
eurjchem-2455	42	19	-	-	PUNCT
eurjchem-2455	42	20	beta6	beta6	NOUN
eurjchem-2455	42	21	(	(	PUNCT
eurjchem-2455	42	22	e6v	e6v	PRON
eurjchem-2455	42	23	)	)	PUNCT
eurjchem-2455	42	24	appears	appear	VERB
eurjchem-2455	42	25	to	to	PART
eurjchem-2455	42	26	fit	fit	VERB
eurjchem-2455	42	27	into	into	ADP
eurjchem-2455	42	28	a	a	DET
eurjchem-2455	42	29	hydrophobic	hydrophobic	NOUN
eurjchem-2455	42	30	pocket	pocket	NOUN
eurjchem-2455	42	31	constituted	constitute	VERB
eurjchem-2455	42	32	by	by	ADP
eurjchem-2455	42	33	β88	β88	PROPN
eurjchem-2455	42	34	leucine	leucine	NOUN
eurjchem-2455	42	35	(	(	PUNCT
eurjchem-2455	42	36	leu	leu	NOUN
eurjchem-2455	42	37	-	-	PUNCT
eurjchem-2455	42	38	beta88	beta88	NOUN
eurjchem-2455	42	39	)	)	PUNCT
eurjchem-2455	42	40	,	,	PUNCT
eurjchem-2455	42	41	β85phenylalanine	β85phenylalanine	X
eurjchem-2455	42	42	(	(	PUNCT
eurjchem-2455	42	43	phe	phe	NOUN
eurjchem-2455	42	44	-	-	PUNCT
eurjchem-2455	42	45	beta85	beta85	NOUN
eurjchem-2455	42	46	)	)	PUNCT
eurjchem-2455	42	47	,	,	PUNCT
eurjchem-2455	42	48	and	and	CCONJ
eurjchem-2455	42	49	β73	β73	NOUN
eurjchem-2455	42	50	aspartic	aspartic	ADJ
eurjchem-2455	42	51	acid	acid	NOUN
eurjchem-2455	42	52	(	(	PUNCT
eurjchem-2455	42	53	asp	asp	NOUN
eurjchem-2455	42	54	-	-	PUNCT
eurjchem-2455	42	55	beta73	beta73	NOUN
eurjchem-2455	42	56	)	)	PUNCT
eurjchem-2455	42	57	residues	residue	NOUN
eurjchem-2455	42	58	on	on	ADP
eurjchem-2455	42	59	adjacent	adjacent	ADJ
eurjchem-2455	42	60	deoxygenated	deoxygenate	VERB
eurjchem-2455	42	61	sickle	sickle	NOUN
eurjchem-2455	42	62	hemoglobin	hemoglobin	NOUN
eurjchem-2455	42	63	molecules	molecule	NOUN
eurjchem-2455	42	64	(	(	PUNCT
eurjchem-2455	42	65	dhbs	dhbs	PROPN
eurjchem-2455	42	66	-	-	PUNCT
eurjchem-2455	42	67	m	m	NOUN
eurjchem-2455	42	68	)	)	PUNCT
eurjchem-2455	42	69	.	.	PUNCT
eurjchem-2455	43	1	abstract	abstract	ADJ
eurjchem-2455	43	2	research	research	NOUN
eurjchem-2455	43	3	article	article	NOUN
eurjchem-2455	43	4	keywords	keyword	VERB
eurjchem-2455	43	5	https://dx.doi.org/10.5155/eurjchem.14.3.370-375.2455	https://dx.doi.org/10.5155/eurjchem.14.3.370-375.2455	PROPN
eurjchem-2455	43	6	https://www.eurjchem.com/	https://www.eurjchem.com/	ADJ
eurjchem-2455	43	7	https://dx.doi.org/10.5155/eurjchem.14.3.370-375.2455	https://dx.doi.org/10.5155/eurjchem.14.3.370-375.2455	PROPN
eurjchem-2455	43	8	mailto:suhailchem.786@gmail.com	mailto:suhailchem.786@gmail.com	PROPN
eurjchem-2455	43	9	http://www.eurjchem.com/	http://www.eurjchem.com/	PROPN
eurjchem-2455	43	10	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.14.3.370-375.2455&domain=pdf&date_stamp=2023-09-30	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.14.3.370-375.2455&domain=pdf&date_stamp=2023-09-30	PROPN
eurjchem-2455	43	11	suhail	suhail	PROPN
eurjchem-2455	43	12	et	et	PROPN
eurjchem-2455	43	13	al	al	PROPN
eurjchem-2455	43	14	.	.	PUNCT
eurjchem-2455	43	15	/	/	SYM
eurjchem-2455	43	16	european	european	PROPN
eurjchem-2455	43	17	journal	journal	PROPN
eurjchem-2455	43	18	of	of	ADP
eurjchem-2455	43	19	chemistry	chemistry	NOUN
eurjchem-2455	43	20	14	14	NUM
eurjchem-2455	43	21	(	(	PUNCT
eurjchem-2455	43	22	3	3	NUM
eurjchem-2455	43	23	)	)	PUNCT
eurjchem-2455	43	24	(	(	PUNCT
eurjchem-2455	43	25	2023	2023	NUM
eurjchem-2455	43	26	)	)	PUNCT
eurjchem-2455	43	27	370	370	NUM
eurjchem-2455	43	28	-	-	SYM
eurjchem-2455	43	29	375	375	NUM
eurjchem-2455	43	30	371	371	NUM
eurjchem-2455	43	31	2023	2023	NUM
eurjchem-2455	43	32	–	–	PUNCT
eurjchem-2455	43	33	european	european	ADJ
eurjchem-2455	43	34	journal	journal	NOUN
eurjchem-2455	43	35	of	of	ADP
eurjchem-2455	43	36	chemistry	chemistry	NOUN
eurjchem-2455	43	37	–	–	PUNCT
eurjchem-2455	43	38	cc	cc	NOUN
eurjchem-2455	43	39	by	by	ADP
eurjchem-2455	43	40	nc	nc	PROPN
eurjchem-2455	43	41	–	–	PUNCT
eurjchem-2455	43	42	doi	doi	NOUN
eurjchem-2455	43	43	:	:	PUNCT
eurjchem-2455	43	44	10.5155	10.5155	NUM
eurjchem-2455	43	45	/	/	SYM
eurjchem-2455	43	46	eurjchem.14.3.370	eurjchem.14.3.370	NOUN
eurjchem-2455	43	47	-	-	NUM
eurjchem-2455	43	48	375.2455	375.2455	NUM
eurjchem-2455	43	49	o	o	NOUN
eurjchem-2455	43	50	o	o	X
eurjchem-2455	43	51	n	n	CCONJ
eurjchem-2455	44	1	nn	nn	INTJ
eurjchem-2455	45	1	oh	oh	INTJ
eurjchem-2455	45	2	o	o	INTJ
eurjchem-2455	45	3	o	o	NOUN
eurjchem-2455	45	4	n	n	CCONJ
eurjchem-2455	46	1	oh	oh	INTJ
eurjchem-2455	47	1	oh	oh	INTJ
eurjchem-2455	47	2	o	o	INTJ
eurjchem-2455	47	3	o	o	NOUN
eurjchem-2455	47	4	n	n	INTJ
eurjchem-2455	48	1	o	o	NOUN
eurjchem-2455	48	2	o	o	X
eurjchem-2455	48	3	o	o	NOUN
eurjchem-2455	48	4	n	n	X
eurjchem-2455	49	1	o	o	NOUN
eurjchem-2455	49	2	o	o	X
eurjchem-2455	49	3	o	o	NOUN
eurjchem-2455	49	4	n	n	CCONJ
eurjchem-2455	49	5	o	o	NOUN
eurjchem-2455	49	6	ho	ho	X
eurjchem-2455	49	7	o	o	X
eurjchem-2455	49	8	o	o	PROPN
eurjchem-2455	49	9	vzhe-039	vzhe-039	VERB
eurjchem-2455	49	10	gbt-440	gbt-440	PROPN
eurjchem-2455	49	11	inn-312	inn-312	PROPN
eurjchem-2455	49	12	saj-310	saj-310	NOUN
eurjchem-2455	49	13	td-07	td-07	NUM
eurjchem-2455	49	14	vanilininn-298	vanilininn-298	ADJ
eurjchem-2455	49	15	o	o	NOUN
eurjchem-2455	50	1	n	n	PRON
eurjchem-2455	51	1	o	o	NOUN
eurjchem-2455	51	2	o	o	X
eurjchem-2455	52	1	oh	oh	INTJ
eurjchem-2455	52	2	(	(	PUNCT
eurjchem-2455	52	3	a	a	NOUN
eurjchem-2455	52	4	)	)	PUNCT
eurjchem-2455	52	5	h	h	PROPN
eurjchem-2455	52	6	ar	ar	PROPN
eurjchem-2455	52	7	c	c	NOUN
eurjchem-2455	53	1	o	o	PROPN
eurjchem-2455	53	2	hbs	hbs	PROPN
eurjchem-2455	53	3	c	c	PROPN
eurjchem-2455	53	4	n	n	PRON
eurjchem-2455	53	5	ch	ch	NOUN
eurjchem-2455	53	6	ch3ch	ch3ch	PROPN
eurjchem-2455	53	7	h3c	h3c	VERB
eurjchem-2455	53	8	o	o	X
eurjchem-2455	54	1	hbs	hbs	PROPN
eurjchem-2455	54	2	c	c	X
eurjchem-2455	54	3	h2n	h2n	PROPN
eurjchem-2455	54	4	ch	ch	PROPN
eurjchem-2455	54	5	ch3	ch3	PROPN
eurjchem-2455	54	6	ch	ch	PROPN
eurjchem-2455	54	7	h3c	h3c	VERB
eurjchem-2455	54	8	h	h	NOUN
eurjchem-2455	54	9	o	o	PROPN
eurjchem-2455	54	10	ar	ar	PROPN
eurjchem-2455	54	11	c	c	NOUN
eurjchem-2455	54	12	+	+	CCONJ
eurjchem-2455	54	13	aromatic	aromatic	ADJ
eurjchem-2455	54	14	aldehyde	aldehyde	NOUN
eurjchem-2455	54	15	hbs	hbs	PROPN
eurjchem-2455	54	16	αval1	αval1	PROPN
eurjchem-2455	54	17	amines	amine	NOUN
eurjchem-2455	54	18	schiff	schiff	NOUN
eurjchem-2455	54	19	base	base	NOUN
eurjchem-2455	54	20	adduct	adduct	NOUN
eurjchem-2455	54	21	(	(	PUNCT
eurjchem-2455	54	22	b	b	NOUN
eurjchem-2455	54	23	)	)	PUNCT
eurjchem-2455	54	24	figure	figure	NOUN
eurjchem-2455	54	25	1	1	NUM
eurjchem-2455	54	26	.	.	PUNCT
eurjchem-2455	55	1	(	(	PUNCT
eurjchem-2455	55	2	a	a	X
eurjchem-2455	55	3	)	)	PUNCT
eurjchem-2455	55	4	the	the	DET
eurjchem-2455	55	5	structure	structure	NOUN
eurjchem-2455	55	6	of	of	ADP
eurjchem-2455	55	7	anti	anti	ADJ
eurjchem-2455	55	8	-	-	ADJ
eurjchem-2455	55	9	sickling	sickling	ADJ
eurjchem-2455	55	10	drugs	drug	NOUN
eurjchem-2455	55	11	[	[	X
eurjchem-2455	55	12	13	13	NUM
eurjchem-2455	55	13	]	]	PUNCT
eurjchem-2455	55	14	,	,	PUNCT
eurjchem-2455	55	15	and	and	CCONJ
eurjchem-2455	55	16	(	(	PUNCT
eurjchem-2455	55	17	b	b	X
eurjchem-2455	55	18	)	)	PUNCT
eurjchem-2455	55	19	their	their	PRON
eurjchem-2455	55	20	literature	literature	NOUN
eurjchem-2455	55	21	data	data	NOUN
eurjchem-2455	55	22	-	-	PUNCT
eurjchem-2455	55	23	based	base	VERB
eurjchem-2455	55	24	mechanism	mechanism	NOUN
eurjchem-2455	55	25	[	[	X
eurjchem-2455	55	26	13	13	NUM
eurjchem-2455	55	27	-	-	SYM
eurjchem-2455	55	28	19	19	NUM
eurjchem-2455	55	29	]	]	PUNCT
eurjchem-2455	55	30	.	.	PUNCT
eurjchem-2455	56	1	due	due	ADP
eurjchem-2455	56	2	to	to	ADP
eurjchem-2455	56	3	this	this	PRON
eurjchem-2455	56	4	,	,	PUNCT
eurjchem-2455	56	5	the	the	DET
eurjchem-2455	56	6	hydrophobic	hydrophobic	NOUN
eurjchem-2455	56	7	β	β	X
eurjchem-2455	56	8	valine	valine	NOUN
eurjchem-2455	56	9	(	(	PUNCT
eurjchem-2455	56	10	valbeta6	valbeta6	NOUN
eurjchem-2455	56	11	)	)	PUNCT
eurjchem-2455	56	12	generates	generate	VERB
eurjchem-2455	56	13	a	a	DET
eurjchem-2455	56	14	‘	'	PUNCT
eurjchem-2455	56	15	sticky	sticky	ADJ
eurjchem-2455	56	16	patch	patch	NOUN
eurjchem-2455	56	17	’	'	PUNCT
eurjchem-2455	56	18	on	on	ADP
eurjchem-2455	56	19	the	the	DET
eurjchem-2455	56	20	β	β	NOUN
eurjchem-2455	56	21	-	-	ADJ
eurjchem-2455	56	22	globin	globin	ADJ
eurjchem-2455	56	23	chain	chain	NOUN
eurjchem-2455	56	24	of	of	ADP
eurjchem-2455	56	25	dhbs	dhbs	PROPN
eurjchem-2455	56	26	-	-	PUNCT
eurjchem-2455	56	27	m	m	NOUN
eurjchem-2455	56	28	[	[	X
eurjchem-2455	56	29	10,11	10,11	NOUN
eurjchem-2455	56	30	]	]	PUNCT
eurjchem-2455	56	31	.	.	PUNCT
eurjchem-2455	57	1	the	the	DET
eurjchem-2455	57	2	hydrophobic	hydrophobic	NOUN
eurjchem-2455	57	3	interaction	interaction	NOUN
eurjchem-2455	57	4	is	be	AUX
eurjchem-2455	57	5	stereospecific	stereospecific	ADJ
eurjchem-2455	57	6	to	to	ADP
eurjchem-2455	57	7	the	the	DET
eurjchem-2455	57	8	leu	leu	NOUN
eurjchem-2455	57	9	-	-	PUNCT
eurjchem-2455	57	10	beta88	beta88	NOUN
eurjchem-2455	57	11	side	side	NOUN
eurjchem-2455	57	12	chain	chain	NOUN
eurjchem-2455	57	13	in	in	ADP
eurjchem-2455	57	14	the	the	DET
eurjchem-2455	57	15	acceptor	acceptor	NOUN
eurjchem-2455	57	16	pocket	pocket	NOUN
eurjchem-2455	57	17	regions	region	NOUN
eurjchem-2455	57	18	on	on	ADP
eurjchem-2455	57	19	adjacent	adjacent	ADJ
eurjchem-2455	57	20	dhbs	dhb	NOUN
eurjchem-2455	57	21	-	-	PUNCT
eurjchem-2455	57	22	m	m	NOUN
eurjchem-2455	57	23	[	[	X
eurjchem-2455	57	24	7	7	NUM
eurjchem-2455	57	25	]	]	PUNCT
eurjchem-2455	57	26	.	.	PUNCT
eurjchem-2455	58	1	besides	besides	SCONJ
eurjchem-2455	58	2	,	,	PUNCT
eurjchem-2455	58	3	the	the	DET
eurjchem-2455	58	4	contact	contact	NOUN
eurjchem-2455	58	5	position	position	NOUN
eurjchem-2455	58	6	on	on	ADP
eurjchem-2455	58	7	dhbs	dhbs	PROPN
eurjchem-2455	58	8	-	-	PUNCT
eurjchem-2455	58	9	m	m	NOUN
eurjchem-2455	58	10	is	be	AUX
eurjchem-2455	58	11	also	also	ADV
eurjchem-2455	58	12	favourable	favourable	ADJ
eurjchem-2455	58	13	for	for	ADP
eurjchem-2455	58	14	the	the	DET
eurjchem-2455	58	15	introduction	introduction	NOUN
eurjchem-2455	58	16	of	of	ADP
eurjchem-2455	58	17	the	the	DET
eurjchem-2455	58	18	r	r	NOUN
eurjchem-2455	58	19	-	-	PUNCT
eurjchem-2455	58	20	group	group	NOUN
eurjchem-2455	58	21	of	of	ADP
eurjchem-2455	58	22	val	val	PROPN
eurjchem-2455	58	23	-	-	PUNCT
eurjchem-2455	58	24	beta6	beta6	NOUN
eurjchem-2455	58	25	in	in	ADP
eurjchem-2455	58	26	this	this	DET
eurjchem-2455	58	27	hydrophobic	hydrophobic	NOUN
eurjchem-2455	58	28	pocket	pocket	NOUN
eurjchem-2455	58	29	[	[	X
eurjchem-2455	58	30	7,10,11	7,10,11	NUM
eurjchem-2455	58	31	]	]	PUNCT
eurjchem-2455	58	32	.	.	PUNCT
eurjchem-2455	59	1	on	on	ADP
eurjchem-2455	59	2	the	the	DET
eurjchem-2455	59	3	other	other	ADJ
eurjchem-2455	59	4	hand	hand	NOUN
eurjchem-2455	59	5	,	,	PUNCT
eurjchem-2455	59	6	the	the	DET
eurjchem-2455	59	7	hydrophilic	hydrophilic	ADJ
eurjchem-2455	59	8	r	r	NOUN
eurjchem-2455	59	9	-	-	PUNCT
eurjchem-2455	59	10	group	group	NOUN
eurjchem-2455	59	11	of	of	ADP
eurjchem-2455	59	12	β	β	X
eurjchem-2455	59	13	glutamic	glutamic	ADJ
eurjchem-2455	59	14	acid	acid	NOUN
eurjchem-2455	59	15	(	(	PUNCT
eurjchem-2455	59	16	glubeta6	glubeta6	PROPN
eurjchem-2455	59	17	)	)	PUNCT
eurjchem-2455	59	18	does	do	AUX
eurjchem-2455	59	19	not	not	PART
eurjchem-2455	59	20	easily	easily	ADV
eurjchem-2455	59	21	fit	fit	VERB
eurjchem-2455	59	22	in	in	ADP
eurjchem-2455	59	23	the	the	DET
eurjchem-2455	59	24	hydrophobic	hydrophobic	NOUN
eurjchem-2455	59	25	pockets	pocket	NOUN
eurjchem-2455	59	26	,	,	PUNCT
eurjchem-2455	59	27	which	which	PRON
eurjchem-2455	59	28	is	be	AUX
eurjchem-2455	59	29	why	why	SCONJ
eurjchem-2455	59	30	polymerization	polymerization	NOUN
eurjchem-2455	59	31	does	do	AUX
eurjchem-2455	59	32	not	not	PART
eurjchem-2455	59	33	occur	occur	VERB
eurjchem-2455	59	34	in	in	ADP
eurjchem-2455	59	35	deoxyhba	deoxyhba	NOUN
eurjchem-2455	59	36	[	[	X
eurjchem-2455	59	37	12	12	NUM
eurjchem-2455	59	38	]	]	PUNCT
eurjchem-2455	59	39	.	.	PUNCT
eurjchem-2455	60	1	here	here	ADV
eurjchem-2455	60	2	,	,	PUNCT
eurjchem-2455	60	3	the	the	DET
eurjchem-2455	60	4	question	question	NOUN
eurjchem-2455	60	5	of	of	ADP
eurjchem-2455	60	6	why	why	SCONJ
eurjchem-2455	60	7	pro	pro	ADJ
eurjchem-2455	60	8	-	-	ADJ
eurjchem-2455	60	9	val	val	ADJ
eurjchem-2455	60	10	-	-	PUNCT
eurjchem-2455	60	11	glu	glu	NOUN
eurjchem-2455	60	12	is	be	AUX
eurjchem-2455	60	13	so	so	ADV
eurjchem-2455	60	14	reactive	reactive	ADJ
eurjchem-2455	60	15	that	that	SCONJ
eurjchem-2455	60	16	it	it	PRON
eurjchem-2455	60	17	attaches	attach	VERB
eurjchem-2455	60	18	to	to	ADP
eurjchem-2455	60	19	the	the	DET
eurjchem-2455	60	20	adjacent	adjacent	ADJ
eurjchem-2455	60	21	hydrophobic	hydrophobic	NOUN
eurjchem-2455	60	22	pocket	pocket	NOUN
eurjchem-2455	60	23	,	,	PUNCT
eurjchem-2455	60	24	while	while	SCONJ
eurjchem-2455	60	25	pgg	pgg	NOUN
eurjchem-2455	60	26	does	do	AUX
eurjchem-2455	60	27	not	not	PART
eurjchem-2455	60	28	arise	arise	VERB
eurjchem-2455	60	29	and	and	CCONJ
eurjchem-2455	60	30	remains	remain	VERB
eurjchem-2455	60	31	constant	constant	ADJ
eurjchem-2455	60	32	.	.	PUNCT
eurjchem-2455	61	1	consequently	consequently	ADV
eurjchem-2455	61	2	,	,	PUNCT
eurjchem-2455	61	3	no	no	DET
eurjchem-2455	61	4	research	research	NOUN
eurjchem-2455	61	5	explained	explain	VERB
eurjchem-2455	61	6	the	the	DET
eurjchem-2455	61	7	reactiveness	reactiveness	NOUN
eurjchem-2455	61	8	of	of	ADP
eurjchem-2455	61	9	β	β	NOUN
eurjchem-2455	61	10	-	-	NOUN
eurjchem-2455	61	11	valine	valine	NOUN
eurjchem-2455	61	12	(	(	PUNCT
eurjchem-2455	61	13	valbeta6	valbeta6	NOUN
eurjchem-2455	61	14	)	)	PUNCT
eurjchem-2455	61	15	of	of	ADP
eurjchem-2455	61	16	(	(	PUNCT
eurjchem-2455	61	17	pro	pro	ADJ
eurjchem-2455	61	18	-	-	ADJ
eurjchem-2455	61	19	val	val	ADJ
eurjchem-2455	61	20	-	-	PUNCT
eurjchem-2455	61	21	glu	glu	NOUN
eurjchem-2455	61	22	)	)	PUNCT
eurjchem-2455	61	23	to	to	PART
eurjchem-2455	61	24	fit	fit	VERB
eurjchem-2455	61	25	into	into	ADP
eurjchem-2455	61	26	hydrophobic	hydrophobic	NOUN
eurjchem-2455	61	27	pockets	pocket	NOUN
eurjchem-2455	61	28	on	on	ADP
eurjchem-2455	61	29	adjacent	adjacent	ADJ
eurjchem-2455	61	30	dhbsm	dhbsm	NOUN
eurjchem-2455	61	31	.	.	PUNCT
eurjchem-2455	62	1	the	the	DET
eurjchem-2455	62	2	us	us	PROPN
eurjchem-2455	62	3	fda	fda	PROPN
eurjchem-2455	62	4	has	have	AUX
eurjchem-2455	62	5	approved	approve	VERB
eurjchem-2455	62	6	gbt-440	gbt-440	NOUN
eurjchem-2455	62	7	(	(	PUNCT
eurjchem-2455	62	8	voxelotor	voxelotor	NOUN
eurjchem-2455	62	9	)	)	PUNCT
eurjchem-2455	62	10	as	as	ADP
eurjchem-2455	62	11	an	an	DET
eurjchem-2455	62	12	antisickling	antisickle	VERB
eurjchem-2455	62	13	agent	agent	NOUN
eurjchem-2455	62	14	[	[	X
eurjchem-2455	62	15	13	13	NUM
eurjchem-2455	62	16	]	]	PUNCT
eurjchem-2455	62	17	.	.	PUNCT
eurjchem-2455	63	1	in	in	ADP
eurjchem-2455	63	2	addition	addition	NOUN
eurjchem-2455	63	3	to	to	ADP
eurjchem-2455	63	4	gbt-440	gbt-440	NOUN
eurjchem-2455	63	5	,	,	PUNCT
eurjchem-2455	63	6	many	many	ADJ
eurjchem-2455	63	7	drugs	drug	NOUN
eurjchem-2455	63	8	[	[	X
eurjchem-2455	63	9	1319	1319	NUM
eurjchem-2455	63	10	]	]	PUNCT
eurjchem-2455	63	11	have	have	AUX
eurjchem-2455	63	12	also	also	ADV
eurjchem-2455	63	13	been	be	AUX
eurjchem-2455	63	14	synthesized	synthesize	VERB
eurjchem-2455	63	15	(	(	PUNCT
eurjchem-2455	63	16	figure	figure	NOUN
eurjchem-2455	63	17	1a	1a	NOUN
eurjchem-2455	63	18	)	)	PUNCT
eurjchem-2455	63	19	whose	whose	DET
eurjchem-2455	63	20	aldehyde	aldehyde	NOUN
eurjchem-2455	63	21	moieties	moiety	NOUN
eurjchem-2455	63	22	form	form	VERB
eurjchem-2455	63	23	the	the	DET
eurjchem-2455	63	24	schiff	schiff	NOUN
eurjchem-2455	63	25	base	base	NOUN
eurjchem-2455	63	26	adduct	adduct	NOUN
eurjchem-2455	63	27	with	with	ADP
eurjchem-2455	63	28	αval1	αval1	ADJ
eurjchem-2455	63	29	n	n	CCONJ
eurjchem-2455	63	30	-	-	PUNCT
eurjchem-2455	63	31	terminal	terminal	ADJ
eurjchem-2455	63	32	amines	amine	NOUN
eurjchem-2455	63	33	(	(	PUNCT
eurjchem-2455	63	34	figure	figure	NOUN
eurjchem-2455	63	35	1b	1b	NUM
eurjchem-2455	63	36	)	)	PUNCT
eurjchem-2455	63	37	.	.	PUNCT
eurjchem-2455	64	1	the	the	DET
eurjchem-2455	64	2	main	main	ADJ
eurjchem-2455	64	3	purpose	purpose	NOUN
eurjchem-2455	64	4	for	for	ADP
eurjchem-2455	64	5	the	the	DET
eurjchem-2455	64	6	synthesis	synthesis	NOUN
eurjchem-2455	64	7	of	of	ADP
eurjchem-2455	64	8	these	these	DET
eurjchem-2455	64	9	drugs	drug	NOUN
eurjchem-2455	64	10	was	be	AUX
eurjchem-2455	64	11	just	just	ADV
eurjchem-2455	64	12	to	to	PART
eurjchem-2455	64	13	increase	increase	VERB
eurjchem-2455	64	14	the	the	DET
eurjchem-2455	64	15	hbs	hbs	ADJ
eurjchem-2455	64	16	protein	protein	NOUN
eurjchem-2455	64	17	affinity	affinity	NOUN
eurjchem-2455	64	18	for	for	ADP
eurjchem-2455	64	19	oxygen	oxygen	NOUN
eurjchem-2455	64	20	.	.	PUNCT
eurjchem-2455	65	1	no	no	DET
eurjchem-2455	65	2	description	description	NOUN
eurjchem-2455	65	3	was	be	AUX
eurjchem-2455	65	4	found	find	VERB
eurjchem-2455	65	5	about	about	ADP
eurjchem-2455	65	6	that	that	DET
eurjchem-2455	65	7	drug	drug	NOUN
eurjchem-2455	65	8	,	,	PUNCT
eurjchem-2455	65	9	which	which	PRON
eurjchem-2455	65	10	may	may	AUX
eurjchem-2455	65	11	attach	attach	VERB
eurjchem-2455	65	12	with	with	ADP
eurjchem-2455	65	13	the	the	DET
eurjchem-2455	65	14	pro	pro	ADJ
eurjchem-2455	65	15	-	-	ADJ
eurjchem-2455	65	16	val	val	ADJ
eurjchem-2455	65	17	-	-	PUNCT
eurjchem-2455	65	18	glu	glu	NOUN
eurjchem-2455	65	19	mutation	mutation	NOUN
eurjchem-2455	65	20	point	point	NOUN
eurjchem-2455	65	21	so	so	SCONJ
eurjchem-2455	65	22	that	that	SCONJ
eurjchem-2455	65	23	the	the	DET
eurjchem-2455	65	24	changes	change	NOUN
eurjchem-2455	65	25	observed	observe	VERB
eurjchem-2455	65	26	due	due	ADP
eurjchem-2455	65	27	to	to	ADP
eurjchem-2455	65	28	the	the	DET
eurjchem-2455	65	29	replacement	replacement	NOUN
eurjchem-2455	65	30	of	of	ADP
eurjchem-2455	65	31	glutamic	glutamic	ADJ
eurjchem-2455	65	32	acid	acid	NOUN
eurjchem-2455	65	33	with	with	ADP
eurjchem-2455	65	34	valine	valine	NOUN
eurjchem-2455	65	35	could	could	AUX
eurjchem-2455	65	36	be	be	AUX
eurjchem-2455	65	37	nullified	nullify	VERB
eurjchem-2455	65	38	.	.	PUNCT
eurjchem-2455	66	1	the	the	DET
eurjchem-2455	66	2	presented	present	VERB
eurjchem-2455	66	3	article	article	NOUN
eurjchem-2455	66	4	suggests	suggest	VERB
eurjchem-2455	66	5	that	that	SCONJ
eurjchem-2455	66	6	it	it	PRON
eurjchem-2455	66	7	could	could	AUX
eurjchem-2455	66	8	be	be	AUX
eurjchem-2455	66	9	possible	possible	ADJ
eurjchem-2455	66	10	in	in	ADP
eurjchem-2455	66	11	the	the	DET
eurjchem-2455	66	12	future	future	NOUN
eurjchem-2455	66	13	if	if	SCONJ
eurjchem-2455	66	14	we	we	PRON
eurjchem-2455	66	15	notice	notice	VERB
eurjchem-2455	66	16	the	the	DET
eurjchem-2455	66	17	gap	gap	NOUN
eurjchem-2455	66	18	found	find	VERB
eurjchem-2455	66	19	in	in	ADP
eurjchem-2455	66	20	the	the	DET
eurjchem-2455	66	21	development	development	NOUN
eurjchem-2455	66	22	of	of	ADP
eurjchem-2455	66	23	antisickling	antisickle	VERB
eurjchem-2455	66	24	agents	agent	NOUN
eurjchem-2455	66	25	.	.	PUNCT
eurjchem-2455	67	1	2	2	X
eurjchem-2455	67	2	.	.	X
eurjchem-2455	67	3	experimental	experimental	ADJ
eurjchem-2455	67	4	2.1	2.1	NUM
eurjchem-2455	67	5	.	.	PUNCT
eurjchem-2455	67	6	software	software	NOUN
eurjchem-2455	67	7	and	and	CCONJ
eurjchem-2455	67	8	tools	tool	NOUN
eurjchem-2455	67	9	all	all	DET
eurjchem-2455	67	10	software	software	NOUN
eurjchem-2455	67	11	and	and	CCONJ
eurjchem-2455	67	12	tools	tool	NOUN
eurjchem-2455	67	13	used	use	VERB
eurjchem-2455	67	14	for	for	ADP
eurjchem-2455	67	15	the	the	DET
eurjchem-2455	67	16	current	current	ADJ
eurjchem-2455	67	17	study	study	NOUN
eurjchem-2455	67	18	are	be	AUX
eurjchem-2455	67	19	the	the	DET
eurjchem-2455	67	20	gaussian	gaussian	ADJ
eurjchem-2455	67	21	03	03	NUM
eurjchem-2455	67	22	program	program	NOUN
eurjchem-2455	67	23	[	[	X
eurjchem-2455	67	24	20	20	NUM
eurjchem-2455	67	25	]	]	PUNCT
eurjchem-2455	67	26	and	and	CCONJ
eurjchem-2455	67	27	gaussview	gaussview	VERB
eurjchem-2455	67	28	6.0	6.0	NUM
eurjchem-2455	67	29	[	[	X
eurjchem-2455	67	30	21	21	NUM
eurjchem-2455	67	31	]	]	PUNCT
eurjchem-2455	67	32	,	,	PUNCT
eurjchem-2455	67	33	discovery	discovery	NOUN
eurjchem-2455	67	34	studio	studio	NOUN
eurjchem-2455	67	35	visualizer	visualizer	PROPN
eurjchem-2455	67	36	2019	2019	NUM
eurjchem-2455	67	37	(	(	PUNCT
eurjchem-2455	67	38	v19.1.0.18287	v19.1.0.18287	NOUN
eurjchem-2455	67	39	)	)	PUNCT
eurjchem-2455	68	1	[	[	X
eurjchem-2455	68	2	22	22	NUM
eurjchem-2455	68	3	]	]	PUNCT
eurjchem-2455	68	4	,	,	PUNCT
eurjchem-2455	68	5	marvinsketch	marvinsketch	PROPN
eurjchem-2455	68	6	(	(	PUNCT
eurjchem-2455	68	7	16.9.12	16.9.12	NUM
eurjchem-2455	68	8	version	version	NOUN
eurjchem-2455	68	9	)	)	PUNCT
eurjchem-2455	68	10	,	,	PUNCT
eurjchem-2455	68	11	chemdraw	chemdraw	VERB
eurjchem-2455	68	12	ultra	ultra	ADJ
eurjchem-2455	68	13	(	(	PUNCT
eurjchem-2455	68	14	12.0.2	12.0.2	NUM
eurjchem-2455	68	15	version	version	NOUN
eurjchem-2455	68	16	)	)	PUNCT
eurjchem-2455	69	1	[	[	X
eurjchem-2455	69	2	23	23	NUM
eurjchem-2455	69	3	]	]	PUNCT
eurjchem-2455	69	4	,	,	PUNCT
eurjchem-2455	69	5	and	and	CCONJ
eurjchem-2455	69	6	protein	protein	NOUN
eurjchem-2455	69	7	data	datum	NOUN
eurjchem-2455	69	8	bank	bank	NOUN
eurjchem-2455	69	9	(	(	PUNCT
eurjchem-2455	69	10	https://www.rcsb.org/	https://www.rcsb.org/	ADJ
eurjchem-2455	69	11	)	)	PUNCT
eurjchem-2455	69	12	.	.	PUNCT
eurjchem-2455	70	1	2.2	2.2	NUM
eurjchem-2455	70	2	.	.	PUNCT
eurjchem-2455	70	3	simulation	simulation	NOUN
eurjchem-2455	70	4	method	method	NOUN
eurjchem-2455	70	5	of	of	ADP
eurjchem-2455	70	6	course	course	NOUN
eurjchem-2455	70	7	,	,	PUNCT
eurjchem-2455	70	8	the	the	DET
eurjchem-2455	70	9	simulation	simulation	NOUN
eurjchem-2455	70	10	study	study	NOUN
eurjchem-2455	70	11	has	have	AUX
eurjchem-2455	70	12	played	play	VERB
eurjchem-2455	70	13	an	an	DET
eurjchem-2455	70	14	important	important	ADJ
eurjchem-2455	70	15	role	role	NOUN
eurjchem-2455	70	16	in	in	ADP
eurjchem-2455	70	17	the	the	DET
eurjchem-2455	70	18	reaction	reaction	NOUN
eurjchem-2455	70	19	mechanism	mechanism	NOUN
eurjchem-2455	70	20	[	[	X
eurjchem-2455	70	21	24	24	NUM
eurjchem-2455	70	22	]	]	PUNCT
eurjchem-2455	70	23	,	,	PUNCT
eurjchem-2455	70	24	chiral	chiral	ADJ
eurjchem-2455	70	25	separation	separation	NOUN
eurjchem-2455	70	26	[	[	X
eurjchem-2455	70	27	25	25	NUM
eurjchem-2455	70	28	-	-	SYM
eurjchem-2455	70	29	28	28	NUM
eurjchem-2455	70	30	]	]	PUNCT
eurjchem-2455	70	31	,	,	PUNCT
eurjchem-2455	70	32	isolation	isolation	NOUN
eurjchem-2455	70	33	of	of	ADP
eurjchem-2455	70	34	the	the	DET
eurjchem-2455	70	35	most	most	ADV
eurjchem-2455	70	36	active	active	ADJ
eurjchem-2455	70	37	gradient	gradient	NOUN
eurjchem-2455	70	38	from	from	ADP
eurjchem-2455	70	39	the	the	DET
eurjchem-2455	70	40	plant	plant	NOUN
eurjchem-2455	70	41	[	[	X
eurjchem-2455	70	42	29	29	NUM
eurjchem-2455	70	43	]	]	PUNCT
eurjchem-2455	70	44	,	,	PUNCT
eurjchem-2455	70	45	and	and	CCONJ
eurjchem-2455	70	46	biological	biological	ADJ
eurjchem-2455	70	47	chemistry	chemistry	NOUN
eurjchem-2455	71	1	[	[	X
eurjchem-2455	71	2	30	30	NUM
eurjchem-2455	71	3	-	-	SYM
eurjchem-2455	71	4	34	34	NUM
eurjchem-2455	71	5	]	]	PUNCT
eurjchem-2455	71	6	,	,	PUNCT
eurjchem-2455	71	7	but	but	CCONJ
eurjchem-2455	71	8	this	this	PRON
eurjchem-2455	71	9	is	be	AUX
eurjchem-2455	71	10	the	the	DET
eurjchem-2455	71	11	first	first	ADJ
eurjchem-2455	71	12	time	time	NOUN
eurjchem-2455	71	13	the	the	DET
eurjchem-2455	71	14	computational	computational	ADJ
eurjchem-2455	71	15	method	method	NOUN
eurjchem-2455	71	16	has	have	AUX
eurjchem-2455	71	17	been	be	AUX
eurjchem-2455	71	18	applied	apply	VERB
eurjchem-2455	71	19	to	to	PART
eurjchem-2455	71	20	know	know	VERB
eurjchem-2455	71	21	the	the	DET
eurjchem-2455	71	22	quantum	quantum	NOUN
eurjchem-2455	71	23	background	background	NOUN
eurjchem-2455	71	24	of	of	ADP
eurjchem-2455	71	25	the	the	DET
eurjchem-2455	71	26	molecular	molecular	ADJ
eurjchem-2455	71	27	disease	disease	NOUN
eurjchem-2455	71	28	.	.	PUNCT
eurjchem-2455	72	1	for	for	ADP
eurjchem-2455	72	2	the	the	DET
eurjchem-2455	72	3	study	study	NOUN
eurjchem-2455	72	4	at	at	ADP
eurjchem-2455	72	5	the	the	DET
eurjchem-2455	72	6	quantum	quantum	ADJ
eurjchem-2455	72	7	level	level	NOUN
eurjchem-2455	72	8	,	,	PUNCT
eurjchem-2455	72	9	the	the	DET
eurjchem-2455	72	10	pdb	pdb	PROPN
eurjchem-2455	72	11	file	file	NOUN
eurjchem-2455	72	12	of	of	ADP
eurjchem-2455	72	13	deoxygenated	deoxygenate	VERB
eurjchem-2455	72	14	hemoglobin	hemoglobin	NOUN
eurjchem-2455	72	15	s	s	PART
eurjchem-2455	72	16	(	(	PUNCT
eurjchem-2455	72	17	βglu6	βglu6	NOUN
eurjchem-2455	72	18	→	→	SYM
eurjchem-2455	72	19	val	val	NOUN
eurjchem-2455	72	20	)	)	PUNCT
eurjchem-2455	72	21	with	with	ADP
eurjchem-2455	72	22	pdb	pdb	PROPN
eurjchem-2455	72	23	code	code	NOUN
eurjchem-2455	73	1	2hbs	2hbs	NUM
eurjchem-2455	74	1	[	[	X
eurjchem-2455	74	2	35	35	NUM
eurjchem-2455	74	3	]	]	PUNCT
eurjchem-2455	74	4	was	be	AUX
eurjchem-2455	74	5	obtained	obtain	VERB
eurjchem-2455	74	6	from	from	ADP
eurjchem-2455	74	7	the	the	DET
eurjchem-2455	74	8	protein	protein	NOUN
eurjchem-2455	74	9	data	datum	NOUN
eurjchem-2455	74	10	bank	bank	NOUN
eurjchem-2455	74	11	.	.	PUNCT
eurjchem-2455	75	1	all	all	DET
eurjchem-2455	75	2	amino	amino	ADJ
eurjchem-2455	75	3	acids	acid	NOUN
eurjchem-2455	75	4	were	be	AUX
eurjchem-2455	75	5	removed	remove	VERB
eurjchem-2455	75	6	except	except	SCONJ
eurjchem-2455	75	7	the	the	DET
eurjchem-2455	75	8	mutation	mutation	NOUN
eurjchem-2455	75	9	point	point	NOUN
eurjchem-2455	75	10	(	(	PUNCT
eurjchem-2455	75	11	pvg	pvg	NOUN
eurjchem-2455	75	12	)	)	PUNCT
eurjchem-2455	75	13	using	use	VERB
eurjchem-2455	75	14	discovery	discovery	NOUN
eurjchem-2455	75	15	studio	studio	NOUN
eurjchem-2455	75	16	(	(	PUNCT
eurjchem-2455	75	17	figure	figure	NOUN
eurjchem-2455	75	18	2	2	NUM
eurjchem-2455	75	19	)	)	PUNCT
eurjchem-2455	75	20	.	.	PUNCT
eurjchem-2455	76	1	the	the	DET
eurjchem-2455	76	2	obtained	obtain	VERB
eurjchem-2455	76	3	file	file	NOUN
eurjchem-2455	76	4	was	be	AUX
eurjchem-2455	76	5	saved	save	VERB
eurjchem-2455	76	6	in	in	ADP
eurjchem-2455	76	7	mol	mol	ADP
eurjchem-2455	76	8	file	file	NOUN
eurjchem-2455	76	9	format	format	NOUN
eurjchem-2455	76	10	.	.	PUNCT
eurjchem-2455	77	1	for	for	ADP
eurjchem-2455	77	2	the	the	DET
eurjchem-2455	77	3	preparation	preparation	NOUN
eurjchem-2455	77	4	of	of	ADP
eurjchem-2455	77	5	the	the	DET
eurjchem-2455	77	6	mol	mol	NOUN
eurjchem-2455	77	7	file	file	NOUN
eurjchem-2455	77	8	of	of	ADP
eurjchem-2455	77	9	pgg	pgg	NOUN
eurjchem-2455	77	10	,	,	PUNCT
eurjchem-2455	77	11	the	the	DET
eurjchem-2455	77	12	mol	mol	ADP
eurjchem-2455	77	13	formatted	formatted	ADJ
eurjchem-2455	77	14	file	file	NOUN
eurjchem-2455	77	15	of	of	ADP
eurjchem-2455	77	16	pvg	pvg	NOUN
eurjchem-2455	77	17	was	be	AUX
eurjchem-2455	77	18	opened	open	VERB
eurjchem-2455	77	19	again	again	ADV
eurjchem-2455	77	20	,	,	PUNCT
eurjchem-2455	77	21	and	and	CCONJ
eurjchem-2455	77	22	valine	valine	NOUN
eurjchem-2455	77	23	was	be	AUX
eurjchem-2455	77	24	replaced	replace	VERB
eurjchem-2455	77	25	with	with	ADP
eurjchem-2455	77	26	glutamic	glutamic	ADJ
eurjchem-2455	77	27	acid	acid	NOUN
eurjchem-2455	77	28	with	with	ADP
eurjchem-2455	77	29	the	the	DET
eurjchem-2455	77	30	help	help	NOUN
eurjchem-2455	77	31	of	of	ADP
eurjchem-2455	77	32	a	a	DET
eurjchem-2455	77	33	marvin	marvin	PROPN
eurjchem-2455	77	34	sketch	sketch	PROPN
eurjchem-2455	77	35	and	and	CCONJ
eurjchem-2455	77	36	saved	save	VERB
eurjchem-2455	77	37	in	in	ADP
eurjchem-2455	77	38	the	the	DET
eurjchem-2455	77	39	same	same	ADJ
eurjchem-2455	77	40	format	format	NOUN
eurjchem-2455	77	41	,	,	PUNCT
eurjchem-2455	77	42	that	that	ADV
eurjchem-2455	77	43	is	is	ADV
eurjchem-2455	77	44	,	,	PUNCT
eurjchem-2455	77	45	the	the	DET
eurjchem-2455	77	46	mol	mol	NOUN
eurjchem-2455	77	47	file	file	NOUN
eurjchem-2455	77	48	format	format	NOUN
eurjchem-2455	77	49	(	(	PUNCT
eurjchem-2455	77	50	figure	figure	NOUN
eurjchem-2455	77	51	2	2	NUM
eurjchem-2455	77	52	)	)	PUNCT
eurjchem-2455	77	53	.	.	PUNCT
eurjchem-2455	78	1	after	after	ADP
eurjchem-2455	78	2	that	that	PRON
eurjchem-2455	78	3	,	,	PUNCT
eurjchem-2455	78	4	both	both	DET
eurjchem-2455	78	5	files	file	NOUN
eurjchem-2455	78	6	were	be	AUX
eurjchem-2455	78	7	used	use	VERB
eurjchem-2455	78	8	for	for	ADP
eurjchem-2455	78	9	theoretical	theoretical	ADJ
eurjchem-2455	78	10	calculation	calculation	NOUN
eurjchem-2455	78	11	in	in	ADP
eurjchem-2455	78	12	the	the	DET
eurjchem-2455	78	13	gaussian(r	gaussian(r	NOUN
eurjchem-2455	78	14	)	)	PUNCT
eurjchem-2455	78	15	03	03	NUM
eurjchem-2455	78	16	program	program	NOUN
eurjchem-2455	79	1	[	[	X
eurjchem-2455	79	2	20	20	NUM
eurjchem-2455	79	3	]	]	PUNCT
eurjchem-2455	79	4	.	.	PUNCT
eurjchem-2455	80	1	three	three	NUM
eurjchem-2455	80	2	basis	basis	NOUN
eurjchem-2455	80	3	sets	set	NOUN
eurjchem-2455	80	4	oniom(rhf/6	oniom(rhf/6	PROPN
eurjchem-2455	80	5	-	-	PUNCT
eurjchem-2455	80	6	31	31	NUM
eurjchem-2455	80	7	g	g	NOUN
eurjchem-2455	80	8	)	)	PUNCT
eurjchem-2455	81	1	[	[	X
eurjchem-2455	81	2	36	36	NUM
eurjchem-2455	81	3	]	]	PUNCT
eurjchem-2455	81	4	,	,	PUNCT
eurjchem-2455	81	5	hf/3	hf/3	PROPN
eurjchem-2455	81	6	-	-	PUNCT
eurjchem-2455	81	7	21+g	21+g	NUM
eurjchem-2455	81	8	*	*	PUNCT
eurjchem-2455	82	1	[	[	X
eurjchem-2455	82	2	37	37	NUM
eurjchem-2455	82	3	]	]	PUNCT
eurjchem-2455	82	4	,	,	PUNCT
eurjchem-2455	82	5	and	and	CCONJ
eurjchem-2455	82	6	b3lyp/3	b3lyp/3	PROPN
eurjchem-2455	82	7	-	-	PUNCT
eurjchem-2455	82	8	21+g	21+g	PROPN
eurjchem-2455	82	9	*	*	PUNCT
eurjchem-2455	83	1	[	[	X
eurjchem-2455	83	2	38,39	38,39	NOUN
eurjchem-2455	83	3	]	]	PUNCT
eurjchem-2455	83	4	were	be	AUX
eurjchem-2455	83	5	used	use	VERB
eurjchem-2455	83	6	in	in	ADP
eurjchem-2455	83	7	the	the	DET
eurjchem-2455	83	8	oniom	oniom	NOUN
eurjchem-2455	83	9	method	method	NOUN
eurjchem-2455	83	10	,	,	PUNCT
eurjchem-2455	83	11	hatree	hatree	ADV
eurjchem-2455	83	12	-	-	PUNCT
eurjchem-2455	83	13	fock	fock	ADJ
eurjchem-2455	83	14	method	method	NOUN
eurjchem-2455	83	15	and	and	CCONJ
eurjchem-2455	83	16	dft	dft	PROPN
eurjchem-2455	83	17	method	method	NOUN
eurjchem-2455	83	18	,	,	PUNCT
eurjchem-2455	83	19	respectively	respectively	ADV
eurjchem-2455	83	20	.	.	PUNCT
eurjchem-2455	84	1	the	the	DET
eurjchem-2455	84	2	results	result	NOUN
eurjchem-2455	84	3	obtained	obtain	VERB
eurjchem-2455	84	4	were	be	AUX
eurjchem-2455	84	5	analyzed	analyze	VERB
eurjchem-2455	84	6	by	by	ADP
eurjchem-2455	84	7	gaussview	gaussview	NOUN
eurjchem-2455	84	8	6.0	6.0	NUM
eurjchem-2455	84	9	[	[	X
eurjchem-2455	84	10	21	21	NUM
eurjchem-2455	84	11	]	]	PUNCT
eurjchem-2455	84	12	.	.	PUNCT
eurjchem-2455	85	1	the	the	DET
eurjchem-2455	85	2	dft	dft	PROPN
eurjchem-2455	85	3	method	method	NOUN
eurjchem-2455	85	4	with	with	ADP
eurjchem-2455	85	5	the	the	DET
eurjchem-2455	85	6	basis	basis	NOUN
eurjchem-2455	85	7	set	set	VERB
eurjchem-2455	85	8	b3lyp/3	b3lyp/3	PROPN
eurjchem-2455	85	9	-	-	PUNCT
eurjchem-2455	85	10	21+g	21+g	PROPN
eurjchem-2455	85	11	*	*	PROPN
eurjchem-2455	85	12	was	be	AUX
eurjchem-2455	85	13	used	use	VERB
eurjchem-2455	85	14	to	to	PART
eurjchem-2455	85	15	reduce	reduce	VERB
eurjchem-2455	85	16	the	the	DET
eurjchem-2455	85	17	approximation	approximation	NOUN
eurjchem-2455	85	18	in	in	ADP
eurjchem-2455	85	19	the	the	DET
eurjchem-2455	85	20	results	result	NOUN
eurjchem-2455	85	21	of	of	ADP
eurjchem-2455	85	22	the	the	DET
eurjchem-2455	85	23	other	other	ADJ
eurjchem-2455	85	24	two	two	NUM
eurjchem-2455	85	25	methods	method	NOUN
eurjchem-2455	85	26	.	.	PUNCT
eurjchem-2455	86	1	in	in	ADP
eurjchem-2455	86	2	the	the	DET
eurjchem-2455	86	3	presented	present	VERB
eurjchem-2455	86	4	study	study	NOUN
eurjchem-2455	86	5	,	,	PUNCT
eurjchem-2455	86	6	the	the	DET
eurjchem-2455	86	7	homo	homo	NOUN
eurjchem-2455	86	8	-	-	PUNCT
eurjchem-2455	86	9	lumo	lumo	NOUN
eurjchem-2455	86	10	energy	energy	NOUN
eurjchem-2455	86	11	gap	gap	NOUN
eurjchem-2455	86	12	in	in	ADP
eurjchem-2455	86	13	both	both	DET
eurjchem-2455	86	14	structures	structure	NOUN
eurjchem-2455	86	15	was	be	AUX
eurjchem-2455	86	16	studied	study	VERB
eurjchem-2455	86	17	in	in	ADP
eurjchem-2455	86	18	depth	depth	NOUN
eurjchem-2455	86	19	.	.	PUNCT
eurjchem-2455	87	1	the	the	DET
eurjchem-2455	87	2	interpretation	interpretation	NOUN
eurjchem-2455	87	3	of	of	ADP
eurjchem-2455	87	4	the	the	DET
eurjchem-2455	87	5	results	result	NOUN
eurjchem-2455	87	6	removed	remove	VERB
eurjchem-2455	87	7	the	the	DET
eurjchem-2455	87	8	curtain	curtain	NOUN
eurjchem-2455	87	9	from	from	ADP
eurjchem-2455	87	10	the	the	DET
eurjchem-2455	87	11	unsolved	unsolved	ADJ
eurjchem-2455	87	12	question	question	NOUN
eurjchem-2455	87	13	regarding	regard	VERB
eurjchem-2455	87	14	the	the	DET
eurjchem-2455	87	15	more	more	ADJ
eurjchem-2455	87	16	reactiveness	reactiveness	NOUN
eurjchem-2455	87	17	of	of	ADP
eurjchem-2455	87	18	the	the	DET
eurjchem-2455	87	19	mutation	mutation	NOUN
eurjchem-2455	87	20	point	point	NOUN
eurjchem-2455	87	21	pvg	pvg	NOUN
eurjchem-2455	87	22	in	in	ADP
eurjchem-2455	87	23	hbs	hbs	PROPN
eurjchem-2455	87	24	as	as	SCONJ
eurjchem-2455	87	25	compared	compare	VERB
eurjchem-2455	87	26	to	to	ADP
eurjchem-2455	87	27	pgg	pgg	PROPN
eurjchem-2455	87	28	in	in	ADP
eurjchem-2455	87	29	hba	hba	NOUN
eurjchem-2455	87	30	.	.	PUNCT
eurjchem-2455	88	1	due	due	ADP
eurjchem-2455	88	2	to	to	ADP
eurjchem-2455	88	3	its	its	PRON
eurjchem-2455	88	4	more	more	ADJ
eurjchem-2455	88	5	reactivity	reactivity	NOUN
eurjchem-2455	88	6	to	to	PART
eurjchem-2455	88	7	fit	fit	VERB
eurjchem-2455	88	8	into	into	ADP
eurjchem-2455	88	9	a	a	DET
eurjchem-2455	88	10	hydrophobic	hydrophobic	ADJ
eurjchem-2455	88	11	residue	residue	NOUN
eurjchem-2455	88	12	on	on	ADP
eurjchem-2455	88	13	adjacent	adjacent	ADJ
eurjchem-2455	88	14	dhbs	dhbs	ADJ
eurjchem-2455	88	15	-	-	PUNCT
eurjchem-2455	88	16	m	m	PROPN
eurjchem-2455	88	17	,	,	PUNCT
eurjchem-2455	88	18	pvg	pvg	PROPN
eurjchem-2455	88	19	generates	generate	VERB
eurjchem-2455	88	20	a	a	DET
eurjchem-2455	88	21	‘	'	PUNCT
eurjchem-2455	88	22	sticky	sticky	ADJ
eurjchem-2455	88	23	patch	patch	NOUN
eurjchem-2455	88	24	’	'	PUNCT
eurjchem-2455	88	25	on	on	ADP
eurjchem-2455	88	26	the	the	DET
eurjchem-2455	88	27	β	β	NOUN
eurjchem-2455	88	28	-	-	ADJ
eurjchem-2455	88	29	globin	globin	ADJ
eurjchem-2455	88	30	chains	chain	NOUN
eurjchem-2455	88	31	of	of	ADP
eurjchem-2455	88	32	dhbs	dhbs	ADJ
eurjchem-2455	88	33	-	-	PUNCT
eurjchem-2455	88	34	m	m	NOUN
eurjchem-2455	88	35	[	[	X
eurjchem-2455	88	36	10,11	10,11	NOUN
eurjchem-2455	88	37	]	]	X
eurjchem-2455	88	38	.	.	PUNCT
eurjchem-2455	89	1	however	however	ADV
eurjchem-2455	89	2	,	,	PUNCT
eurjchem-2455	89	3	the	the	DET
eurjchem-2455	89	4	hydrophobic	hydrophobic	ADJ
eurjchem-2455	89	5	nature	nature	NOUN
eurjchem-2455	89	6	of	of	ADP
eurjchem-2455	89	7	both	both	DET
eurjchem-2455	89	8	links	link	NOUN
eurjchem-2455	89	9	(	(	PUNCT
eurjchem-2455	89	10	pgg	pgg	NOUN
eurjchem-2455	89	11	and	and	CCONJ
eurjchem-2455	89	12	pvg	pvg	PROPN
eurjchem-2455	89	13	)	)	PUNCT
eurjchem-2455	89	14	was	be	AUX
eurjchem-2455	89	15	also	also	ADV
eurjchem-2455	89	16	valued	value	VERB
eurjchem-2455	89	17	so	so	SCONJ
eurjchem-2455	89	18	that	that	SCONJ
eurjchem-2455	89	19	the	the	DET
eurjchem-2455	89	20	hydrophobicity	hydrophobicity	NOUN
eurjchem-2455	89	21	-	-	PUNCT
eurjchem-2455	89	22	based	base	VERB
eurjchem-2455	89	23	difference	difference	NOUN
eurjchem-2455	89	24	between	between	ADP
eurjchem-2455	89	25	pgg	pgg	PROPN
eurjchem-2455	89	26	and	and	CCONJ
eurjchem-2455	89	27	pvg	pvg	NOUN
eurjchem-2455	89	28	could	could	AUX
eurjchem-2455	89	29	be	be	AUX
eurjchem-2455	89	30	evaluated	evaluate	VERB
eurjchem-2455	89	31	.	.	PUNCT
eurjchem-2455	90	1	for	for	ADP
eurjchem-2455	90	2	this	this	DET
eurjchem-2455	90	3	purpose	purpose	NOUN
eurjchem-2455	90	4	,	,	PUNCT
eurjchem-2455	90	5	all	all	DET
eurjchem-2455	90	6	parameters	parameter	NOUN
eurjchem-2455	90	7	related	relate	VERB
eurjchem-2455	90	8	to	to	ADP
eurjchem-2455	90	9	hydrophobicity	hydrophobicity	NOUN
eurjchem-2455	90	10	were	be	AUX
eurjchem-2455	90	11	studied	study	VERB
eurjchem-2455	90	12	computationally	computationally	ADV
eurjchem-2455	90	13	.	.	PUNCT
eurjchem-2455	91	1	for	for	ADP
eurjchem-2455	91	2	instance	instance	NOUN
eurjchem-2455	91	3	,	,	PUNCT
eurjchem-2455	91	4	the	the	DET
eurjchem-2455	91	5	hydrophobicity	hydrophobicity	NOUN
eurjchem-2455	91	6	-	-	PUNCT
eurjchem-2455	91	7	related	relate	VERB
eurjchem-2455	91	8	log	log	NOUN
eurjchem-2455	91	9	p	p	NOUN
eurjchem-2455	91	10	(	(	PUNCT
eurjchem-2455	91	11	partition	partition	NOUN
eurjchem-2455	91	12	coefficient	coefficient	NOUN
eurjchem-2455	91	13	)	)	PUNCT
eurjchem-2455	91	14	,	,	PUNCT
eurjchem-2455	91	15	cmr	cmr	PROPN
eurjchem-2455	91	16	(	(	PUNCT
eurjchem-2455	91	17	calculated	calculate	VERB
eurjchem-2455	91	18	molar	molar	ADJ
eurjchem-2455	91	19	refractivity	refractivity	NOUN
eurjchem-2455	91	20	)	)	PUNCT
eurjchem-2455	91	21	,	,	PUNCT
eurjchem-2455	91	22	mr	mr	PROPN
eurjchem-2455	91	23	https://www.rcsb.org/	https://www.rcsb.org/	VERB
eurjchem-2455	91	24	372	372	NUM
eurjchem-2455	91	25	suhail	suhail	NOUN
eurjchem-2455	91	26	et	et	PROPN
eurjchem-2455	91	27	al	al	PROPN
eurjchem-2455	91	28	.	.	PUNCT
eurjchem-2455	91	29	/	/	SYM
eurjchem-2455	91	30	european	european	PROPN
eurjchem-2455	91	31	journal	journal	PROPN
eurjchem-2455	91	32	of	of	ADP
eurjchem-2455	91	33	chemistry	chemistry	NOUN
eurjchem-2455	91	34	14	14	NUM
eurjchem-2455	91	35	(	(	PUNCT
eurjchem-2455	91	36	3	3	NUM
eurjchem-2455	91	37	)	)	PUNCT
eurjchem-2455	91	38	(	(	PUNCT
eurjchem-2455	91	39	2023	2023	NUM
eurjchem-2455	91	40	)	)	PUNCT
eurjchem-2455	91	41	370	370	NUM
eurjchem-2455	91	42	-	-	SYM
eurjchem-2455	91	43	375	375	NUM
eurjchem-2455	91	44	2023	2023	NUM
eurjchem-2455	91	45	–	–	PUNCT
eurjchem-2455	91	46	european	european	ADJ
eurjchem-2455	91	47	journal	journal	NOUN
eurjchem-2455	91	48	of	of	ADP
eurjchem-2455	91	49	chemistry	chemistry	NOUN
eurjchem-2455	91	50	–	–	PUNCT
eurjchem-2455	91	51	cc	cc	NOUN
eurjchem-2455	91	52	by	by	ADP
eurjchem-2455	91	53	nc	nc	PROPN
eurjchem-2455	91	54	–	–	PUNCT
eurjchem-2455	91	55	doi	doi	NOUN
eurjchem-2455	91	56	:	:	PUNCT
eurjchem-2455	91	57	10.5155	10.5155	NUM
eurjchem-2455	91	58	/	/	SYM
eurjchem-2455	91	59	eurjchem.14.3.370	eurjchem.14.3.370	NOUN
eurjchem-2455	91	60	-	-	PUNCT
eurjchem-2455	91	61	375.2455	375.2455	NUM
eurjchem-2455	91	62	table	table	NOUN
eurjchem-2455	91	63	1	1	NUM
eurjchem-2455	91	64	.	.	PUNCT
eurjchem-2455	91	65	egap	egap	PROPN
eurjchem-2455	91	66	variation	variation	NOUN
eurjchem-2455	91	67	in	in	ADP
eurjchem-2455	91	68	pgg	pgg	PROPN
eurjchem-2455	91	69	and	and	CCONJ
eurjchem-2455	91	70	pvg	pvg	PROPN
eurjchem-2455	91	71	.	.	PROPN
eurjchem-2455	92	1	method	method	PROPN
eurjchem-2455	92	2	basis	basis	NOUN
eurjchem-2455	92	3	set	set	NOUN
eurjchem-2455	92	4	link	link	NOUN
eurjchem-2455	92	5	homo	homo	NOUN
eurjchem-2455	92	6	(	(	PUNCT
eurjchem-2455	92	7	ev	ev	NOUN
eurjchem-2455	92	8	)	)	PUNCT
eurjchem-2455	92	9	lumo	lumo	NOUN
eurjchem-2455	92	10	(	(	PUNCT
eurjchem-2455	92	11	ev	ev	INTJ
eurjchem-2455	92	12	)	)	PUNCT
eurjchem-2455	92	13	egap	egap	NOUN
eurjchem-2455	92	14	(	(	PUNCT
eurjchem-2455	92	15	ev	ev	NOUN
eurjchem-2455	92	16	)	)	PUNCT
eurjchem-2455	92	17	reactivity	reactivity	NOUN
eurjchem-2455	92	18	result	result	NOUN
eurjchem-2455	92	19	dft	dft	PROPN
eurjchem-2455	92	20	b3lyp/3	b3lyp/3	PROPN
eurjchem-2455	92	21	-	-	PUNCT
eurjchem-2455	92	22	21+g	21+g	PROPN
eurjchem-2455	92	23	*	*	PROPN
eurjchem-2455	92	24	pgg	pgg	PROPN
eurjchem-2455	92	25	-6.79300	-6.79300	PROPN
eurjchem-2455	92	26	-1.61036	-1.61036	PROPN
eurjchem-2455	93	1	5.18264	5.18264	NUM
eurjchem-2455	93	2	pvg	pvg	X
eurjchem-2455	93	3	>	>	X
eurjchem-2455	93	4	pgg	pgg	PROPN
eurjchem-2455	93	5	pvg	pvg	PROPN
eurjchem-2455	93	6	-6.62323	-6.62323	PROPN
eurjchem-2455	93	7	-1.64192	-1.64192	X
eurjchem-2455	93	8	4.98131	4.98131	NUM
eurjchem-2455	93	9	hartree	hartree	ADJ
eurjchem-2455	93	10	fock	fock	ADJ
eurjchem-2455	93	11	hf/3	hf/3	PROPN
eurjchem-2455	93	12	-	-	PUNCT
eurjchem-2455	93	13	21+g	21+g	PROPN
eurjchem-2455	93	14	*	*	NOUN
eurjchem-2455	93	15	pgg	pgg	NOUN
eurjchem-2455	93	16	-10.6388	-10.6388	NUM
eurjchem-2455	93	17	1.19185	1.19185	NUM
eurjchem-2455	93	18	11.83065	11.83065	NUM
eurjchem-2455	93	19	pvg	pvg	NOUN
eurjchem-2455	93	20	-10.3748	-10.3748	PUNCT
eurjchem-2455	93	21	1.23321	1.23321	NUM
eurjchem-2455	93	22	11.60801	11.60801	NUM
eurjchem-2455	93	23	hartree	hartree	ADJ
eurjchem-2455	93	24	fock	fock	ADJ
eurjchem-2455	93	25	oniom	oniom	NOUN
eurjchem-2455	93	26	(	(	PUNCT
eurjchem-2455	93	27	rhf/6	rhf/6	NOUN
eurjchem-2455	93	28	-	-	PUNCT
eurjchem-2455	93	29	31	31	NUM
eurjchem-2455	93	30	g	g	NOUN
eurjchem-2455	93	31	)	)	PUNCT
eurjchem-2455	93	32	pgg	pgg	NOUN
eurjchem-2455	93	33	-10.9637	-10.9637	NUM
eurjchem-2455	93	34	2.71024	2.71024	NUM
eurjchem-2455	93	35	13.67394	13.67394	NUM
eurjchem-2455	93	36	pvg	pvg	NOUN
eurjchem-2455	93	37	-10.18872	-10.18872	PUNCT
eurjchem-2455	93	38	2.88222	2.88222	NUM
eurjchem-2455	93	39	13.07094	13.07094	NUM
eurjchem-2455	93	40	figure	figure	NOUN
eurjchem-2455	93	41	2	2	NUM
eurjchem-2455	93	42	.	.	PUNCT
eurjchem-2455	93	43	the	the	DET
eurjchem-2455	93	44	protocol	protocol	NOUN
eurjchem-2455	93	45	for	for	ADP
eurjchem-2455	93	46	the	the	DET
eurjchem-2455	93	47	quantum	quantum	ADJ
eurjchem-2455	93	48	level	level	NOUN
eurjchem-2455	93	49	study	study	NOUN
eurjchem-2455	93	50	(	(	PUNCT
eurjchem-2455	93	51	egap	egap	PROPN
eurjchem-2455	93	52	=	=	SYM
eurjchem-2455	93	53	homo	homo	ADJ
eurjchem-2455	93	54	-	-	PUNCT
eurjchem-2455	93	55	lumo	lumo	NOUN
eurjchem-2455	93	56	energy	energy	NOUN
eurjchem-2455	93	57	gap	gap	NOUN
eurjchem-2455	93	58	)	)	PUNCT
eurjchem-2455	93	59	.	.	PUNCT
eurjchem-2455	94	1	(	(	PUNCT
eurjchem-2455	94	2	remanent	remanent	NOUN
eurjchem-2455	94	3	magnetization	magnetization	NOUN
eurjchem-2455	94	4	)	)	PUNCT
eurjchem-2455	94	5	and	and	CCONJ
eurjchem-2455	94	6	tpsa	tpsa	NOUN
eurjchem-2455	94	7	(	(	PUNCT
eurjchem-2455	94	8	topological	topological	ADJ
eurjchem-2455	94	9	polar	polar	ADJ
eurjchem-2455	94	10	surface	surface	NOUN
eurjchem-2455	94	11	area	area	NOUN
eurjchem-2455	94	12	)	)	PUNCT
eurjchem-2455	94	13	of	of	ADP
eurjchem-2455	94	14	pgg	pgg	PROPN
eurjchem-2455	94	15	and	and	CCONJ
eurjchem-2455	94	16	pvg	pvg	PROPN
eurjchem-2455	94	17	were	be	AUX
eurjchem-2455	94	18	observed	observe	VERB
eurjchem-2455	94	19	using	use	VERB
eurjchem-2455	94	20	chemdraw	chemdraw	NOUN
eurjchem-2455	94	21	.	.	PUNCT
eurjchem-2455	95	1	the	the	DET
eurjchem-2455	95	2	logp	logp	NOUN
eurjchem-2455	95	3	is	be	AUX
eurjchem-2455	95	4	a	a	DET
eurjchem-2455	95	5	negative	negative	ADJ
eurjchem-2455	95	6	value	value	NOUN
eurjchem-2455	95	7	for	for	ADP
eurjchem-2455	95	8	hydrophilic	hydrophilic	ADJ
eurjchem-2455	95	9	compounds	compound	NOUN
eurjchem-2455	95	10	(	(	PUNCT
eurjchem-2455	95	11	higher	high	ADJ
eurjchem-2455	95	12	affinity	affinity	NOUN
eurjchem-2455	95	13	for	for	ADP
eurjchem-2455	95	14	the	the	DET
eurjchem-2455	95	15	aqueous	aqueous	ADJ
eurjchem-2455	95	16	phase	phase	NOUN
eurjchem-2455	95	17	)	)	PUNCT
eurjchem-2455	95	18	,	,	PUNCT
eurjchem-2455	95	19	and	and	CCONJ
eurjchem-2455	95	20	a	a	DET
eurjchem-2455	95	21	positive	positive	ADJ
eurjchem-2455	95	22	value	value	NOUN
eurjchem-2455	95	23	for	for	ADP
eurjchem-2455	95	24	hydrophilic	hydrophilic	ADJ
eurjchem-2455	95	25	compounds	compound	NOUN
eurjchem-2455	95	26	[	[	X
eurjchem-2455	95	27	40	40	NUM
eurjchem-2455	95	28	]	]	PUNCT
eurjchem-2455	95	29	;	;	PUNCT
eurjchem-2455	95	30	cmr	cmr	NOUN
eurjchem-2455	95	31	is	be	AUX
eurjchem-2455	95	32	a	a	DET
eurjchem-2455	95	33	calculated	calculated	ADJ
eurjchem-2455	95	34	molar	molar	ADJ
eurjchem-2455	95	35	refractivity	refractivity	NOUN
eurjchem-2455	95	36	of	of	ADP
eurjchem-2455	95	37	one	one	NUM
eurjchem-2455	95	38	mole	mole	NOUN
eurjchem-2455	95	39	of	of	ADP
eurjchem-2455	95	40	a	a	DET
eurjchem-2455	95	41	substance	substance	NOUN
eurjchem-2455	95	42	[	[	X
eurjchem-2455	95	43	41	41	NUM
eurjchem-2455	95	44	]	]	PUNCT
eurjchem-2455	95	45	;	;	PUNCT
eurjchem-2455	95	46	mr	mr	PROPN
eurjchem-2455	95	47	is	be	AUX
eurjchem-2455	95	48	the	the	DET
eurjchem-2455	95	49	magnetization	magnetization	NOUN
eurjchem-2455	95	50	that	that	PRON
eurjchem-2455	95	51	remains	remain	VERB
eurjchem-2455	95	52	after	after	ADP
eurjchem-2455	95	53	removal	removal	NOUN
eurjchem-2455	95	54	a	a	DET
eurjchem-2455	95	55	sufficiently	sufficiently	ADV
eurjchem-2455	95	56	large	large	ADJ
eurjchem-2455	95	57	field	field	NOUN
eurjchem-2455	95	58	to	to	PART
eurjchem-2455	95	59	reach	reach	VERB
eurjchem-2455	95	60	the	the	DET
eurjchem-2455	95	61	saturation	saturation	NOUN
eurjchem-2455	95	62	magnetization	magnetization	NOUN
eurjchem-2455	95	63	[	[	X
eurjchem-2455	95	64	42	42	NUM
eurjchem-2455	95	65	]	]	PUNCT
eurjchem-2455	95	66	and	and	CCONJ
eurjchem-2455	95	67	tpsa	tpsa	NOUN
eurjchem-2455	95	68	is	be	AUX
eurjchem-2455	95	69	the	the	DET
eurjchem-2455	95	70	surface	surface	NOUN
eurjchem-2455	95	71	sum	sum	NOUN
eurjchem-2455	95	72	over	over	ADP
eurjchem-2455	95	73	all	all	DET
eurjchem-2455	95	74	polar	polar	ADJ
eurjchem-2455	95	75	atoms	atom	NOUN
eurjchem-2455	95	76	or	or	CCONJ
eurjchem-2455	95	77	molecules	molecule	NOUN
eurjchem-2455	95	78	,	,	PUNCT
eurjchem-2455	95	79	primarily	primarily	ADV
eurjchem-2455	95	80	oxygen	oxygen	NOUN
eurjchem-2455	95	81	and	and	CCONJ
eurjchem-2455	95	82	nitrogen	nitrogen	NOUN
eurjchem-2455	95	83	,	,	PUNCT
eurjchem-2455	95	84	also	also	ADV
eurjchem-2455	95	85	including	include	VERB
eurjchem-2455	95	86	their	their	PRON
eurjchem-2455	95	87	attached	attach	VERB
eurjchem-2455	95	88	hydrogen	hydrogen	NOUN
eurjchem-2455	95	89	atoms	atom	NOUN
eurjchem-2455	95	90	[	[	X
eurjchem-2455	95	91	43	43	NUM
eurjchem-2455	95	92	]	]	PUNCT
eurjchem-2455	95	93	.	.	PUNCT
eurjchem-2455	96	1	in	in	ADP
eurjchem-2455	96	2	addition	addition	NOUN
eurjchem-2455	96	3	to	to	ADP
eurjchem-2455	96	4	these	these	DET
eurjchem-2455	96	5	things	thing	NOUN
eurjchem-2455	96	6	,	,	PUNCT
eurjchem-2455	96	7	the	the	DET
eurjchem-2455	96	8	values	value	NOUN
eurjchem-2455	96	9	of	of	ADP
eurjchem-2455	96	10	henry	henry	PROPN
eurjchem-2455	96	11	’s	’s	PART
eurjchem-2455	96	12	law	law	NOUN
eurjchem-2455	96	13	,	,	PUNCT
eurjchem-2455	96	14	heat	heat	NOUN
eurjchem-2455	96	15	of	of	ADP
eurjchem-2455	96	16	form	form	NOUN
eurjchem-2455	96	17	,	,	PUNCT
eurjchem-2455	96	18	dipole	dipole	NOUN
eurjchem-2455	96	19	moment	moment	NOUN
eurjchem-2455	96	20	,	,	PUNCT
eurjchem-2455	96	21	clogp	clogp	ADJ
eurjchem-2455	96	22	,	,	PUNCT
eurjchem-2455	96	23	and	and	CCONJ
eurjchem-2455	96	24	other	other	ADJ
eurjchem-2455	96	25	important	important	ADJ
eurjchem-2455	96	26	parameters	parameter	NOUN
eurjchem-2455	96	27	were	be	AUX
eurjchem-2455	96	28	also	also	ADV
eurjchem-2455	96	29	renowned	renowned	ADJ
eurjchem-2455	96	30	.	.	PUNCT
eurjchem-2455	97	1	3	3	X
eurjchem-2455	97	2	.	.	NOUN
eurjchem-2455	97	3	results	result	NOUN
eurjchem-2455	97	4	and	and	CCONJ
eurjchem-2455	97	5	discussion	discussion	NOUN
eurjchem-2455	97	6	after	after	ADP
eurjchem-2455	97	7	hartree	hartree	NOUN
eurjchem-2455	97	8	-	-	PUNCT
eurjchem-2455	97	9	fock	fock	ADJ
eurjchem-2455	97	10	,	,	PUNCT
eurjchem-2455	97	11	dft	dft	PROPN
eurjchem-2455	97	12	,	,	PUNCT
eurjchem-2455	97	13	and	and	CCONJ
eurjchem-2455	97	14	oniom	oniom	PROPN
eurjchem-2455	97	15	calculations	calculation	NOUN
eurjchem-2455	97	16	,	,	PUNCT
eurjchem-2455	97	17	both	both	DET
eurjchem-2455	97	18	structures	structure	NOUN
eurjchem-2455	97	19	were	be	AUX
eurjchem-2455	97	20	found	find	VERB
eurjchem-2455	97	21	to	to	PART
eurjchem-2455	97	22	be	be	AUX
eurjchem-2455	97	23	different	different	ADJ
eurjchem-2455	97	24	in	in	ADP
eurjchem-2455	97	25	their	their	PRON
eurjchem-2455	97	26	homo	homo	ADJ
eurjchem-2455	97	27	-	-	PUNCT
eurjchem-2455	97	28	lumo	lumo	NOUN
eurjchem-2455	97	29	energy	energy	NOUN
eurjchem-2455	97	30	gaps	gap	NOUN
eurjchem-2455	97	31	(	(	PUNCT
eurjchem-2455	97	32	egap	egap	NOUN
eurjchem-2455	97	33	)	)	PUNCT
eurjchem-2455	97	34	.	.	PUNCT
eurjchem-2455	98	1	three	three	NUM
eurjchem-2455	98	2	basis	basis	NOUN
eurjchem-2455	98	3	sets	set	NOUN
eurjchem-2455	98	4	used	use	VERB
eurjchem-2455	98	5	for	for	ADP
eurjchem-2455	98	6	the	the	DET
eurjchem-2455	98	7	quantum	quantum	ADJ
eurjchem-2455	98	8	calculation	calculation	NOUN
eurjchem-2455	98	9	gave	give	VERB
eurjchem-2455	98	10	the	the	DET
eurjchem-2455	98	11	same	same	ADJ
eurjchem-2455	98	12	results	result	NOUN
eurjchem-2455	98	13	,	,	PUNCT
eurjchem-2455	98	14	i.e.	i.e.	X
eurjchem-2455	98	15	,	,	PUNCT
eurjchem-2455	98	16	egap	egap	NOUN
eurjchem-2455	98	17	of	of	ADP
eurjchem-2455	98	18	pgg	pgg	PROPN
eurjchem-2455	98	19	was	be	AUX
eurjchem-2455	98	20	found	find	VERB
eurjchem-2455	98	21	to	to	PART
eurjchem-2455	98	22	be	be	AUX
eurjchem-2455	98	23	higher	high	ADJ
eurjchem-2455	98	24	than	than	ADP
eurjchem-2455	98	25	that	that	PRON
eurjchem-2455	98	26	of	of	ADP
eurjchem-2455	98	27	pvg	pvg	PROPN
eurjchem-2455	98	28	(	(	PUNCT
eurjchem-2455	98	29	table	table	NOUN
eurjchem-2455	98	30	1	1	NUM
eurjchem-2455	98	31	)	)	PUNCT
eurjchem-2455	98	32	.	.	PUNCT
eurjchem-2455	99	1	figure	figure	NOUN
eurjchem-2455	99	2	3	3	NUM
eurjchem-2455	99	3	shows	show	VERB
eurjchem-2455	99	4	a	a	DET
eurjchem-2455	99	5	3d	3d	NUM
eurjchem-2455	99	6	pose	pose	NOUN
eurjchem-2455	99	7	of	of	ADP
eurjchem-2455	99	8	homo	homo	NOUN
eurjchem-2455	99	9	-	-	PUNCT
eurjchem-2455	99	10	lumo	lumo	NOUN
eurjchem-2455	99	11	of	of	ADP
eurjchem-2455	99	12	both	both	DET
eurjchem-2455	99	13	structures	structure	NOUN
eurjchem-2455	99	14	,	,	PUNCT
eurjchem-2455	99	15	i.e.	i.e.	X
eurjchem-2455	99	16	,	,	PUNCT
eurjchem-2455	99	17	pgg	pgg	NOUN
eurjchem-2455	99	18	of	of	ADP
eurjchem-2455	99	19	hba	hba	PROPN
eurjchem-2455	99	20	and	and	CCONJ
eurjchem-2455	99	21	pvg	pvg	NOUN
eurjchem-2455	99	22	of	of	ADP
eurjchem-2455	99	23	hbs	hbs	PROPN
eurjchem-2455	99	24	.	.	PUNCT
eurjchem-2455	100	1	according	accord	VERB
eurjchem-2455	100	2	to	to	ADP
eurjchem-2455	100	3	data	datum	NOUN
eurjchem-2455	100	4	from	from	ADP
eurjchem-2455	100	5	the	the	DET
eurjchem-2455	100	6	literature	literature	NOUN
eurjchem-2455	100	7	[	[	X
eurjchem-2455	100	8	44	44	NUM
eurjchem-2455	100	9	-	-	SYM
eurjchem-2455	100	10	47	47	NUM
eurjchem-2455	100	11	]	]	PUNCT
eurjchem-2455	100	12	,	,	PUNCT
eurjchem-2455	100	13	a	a	DET
eurjchem-2455	100	14	molecule	molecule	NOUN
eurjchem-2455	100	15	with	with	ADP
eurjchem-2455	100	16	a	a	DET
eurjchem-2455	100	17	higher	high	ADJ
eurjchem-2455	100	18	frontier	frontier	NOUN
eurjchem-2455	100	19	orbital	orbital	ADJ
eurjchem-2455	100	20	gap	gap	NOUN
eurjchem-2455	100	21	(	(	PUNCT
eurjchem-2455	100	22	homo	homo	NOUN
eurjchem-2455	100	23	-	-	PUNCT
eurjchem-2455	100	24	lumo	lumo	NOUN
eurjchem-2455	100	25	energy	energy	NOUN
eurjchem-2455	100	26	gap	gap	NOUN
eurjchem-2455	100	27	)	)	PUNCT
eurjchem-2455	100	28	has	have	VERB
eurjchem-2455	100	29	low	low	ADJ
eurjchem-2455	100	30	chemical	chemical	NOUN
eurjchem-2455	100	31	reactivity	reactivity	NOUN
eurjchem-2455	100	32	and	and	CCONJ
eurjchem-2455	100	33	high	high	ADJ
eurjchem-2455	100	34	kinetic	kinetic	ADJ
eurjchem-2455	100	35	stability	stability	NOUN
eurjchem-2455	100	36	because	because	SCONJ
eurjchem-2455	100	37	it	it	PRON
eurjchem-2455	100	38	is	be	AUX
eurjchem-2455	100	39	energetically	energetically	ADV
eurjchem-2455	100	40	unfavorable	unfavorable	ADJ
eurjchem-2455	100	41	to	to	PART
eurjchem-2455	100	42	add	add	VERB
eurjchem-2455	100	43	an	an	DET
eurjchem-2455	100	44	electron	electron	NOUN
eurjchem-2455	100	45	to	to	ADP
eurjchem-2455	100	46	the	the	DET
eurjchem-2455	100	47	high	high	ADV
eurjchem-2455	100	48	-	-	PUNCT
eurjchem-2455	100	49	lying	lie	VERB
eurjchem-2455	100	50	lumo	lumo	NOUN
eurjchem-2455	100	51	in	in	ADP
eurjchem-2455	100	52	order	order	NOUN
eurjchem-2455	100	53	to	to	PART
eurjchem-2455	100	54	remove	remove	VERB
eurjchem-2455	100	55	electrons	electron	NOUN
eurjchem-2455	100	56	from	from	ADP
eurjchem-2455	100	57	the	the	DET
eurjchem-2455	100	58	low	low	ADV
eurjchem-2455	100	59	-	-	PUNCT
eurjchem-2455	100	60	lying	lie	VERB
eurjchem-2455	100	61	homo	homo	NOUN
eurjchem-2455	100	62	.	.	PUNCT
eurjchem-2455	101	1	if	if	SCONJ
eurjchem-2455	101	2	egap	egap	PROPN
eurjchem-2455	101	3	is	be	AUX
eurjchem-2455	101	4	higher	high	ADJ
eurjchem-2455	101	5	,	,	PUNCT
eurjchem-2455	101	6	it	it	PRON
eurjchem-2455	101	7	becomes	become	VERB
eurjchem-2455	101	8	energetically	energetically	ADV
eurjchem-2455	101	9	unfavorable	unfavorable	ADJ
eurjchem-2455	101	10	for	for	SCONJ
eurjchem-2455	101	11	an	an	DET
eurjchem-2455	101	12	electron	electron	NOUN
eurjchem-2455	101	13	to	to	PART
eurjchem-2455	101	14	jump	jump	VERB
eurjchem-2455	101	15	from	from	ADP
eurjchem-2455	101	16	homo	homo	NOUN
eurjchem-2455	101	17	to	to	ADP
eurjchem-2455	101	18	lumo	lumo	NOUN
eurjchem-2455	101	19	[	[	X
eurjchem-2455	101	20	24,48	24,48	NOUN
eurjchem-2455	101	21	]	]	PUNCT
eurjchem-2455	101	22	,	,	PUNCT
eurjchem-2455	101	23	which	which	PRON
eurjchem-2455	101	24	is	be	AUX
eurjchem-2455	101	25	why	why	SCONJ
eurjchem-2455	101	26	conditions	condition	NOUN
eurjchem-2455	101	27	become	become	VERB
eurjchem-2455	101	28	very	very	ADV
eurjchem-2455	101	29	difficult	difficult	ADJ
eurjchem-2455	101	30	for	for	SCONJ
eurjchem-2455	101	31	a	a	DET
eurjchem-2455	101	32	molecule	molecule	NOUN
eurjchem-2455	101	33	to	to	PART
eurjchem-2455	101	34	take	take	VERB
eurjchem-2455	101	35	part	part	NOUN
eurjchem-2455	101	36	in	in	ADP
eurjchem-2455	101	37	a	a	DET
eurjchem-2455	101	38	chemical	chemical	NOUN
eurjchem-2455	101	39	reaction	reaction	NOUN
eurjchem-2455	101	40	.	.	PUNCT
eurjchem-2455	102	1	on	on	ADP
eurjchem-2455	102	2	the	the	DET
eurjchem-2455	102	3	other	other	ADJ
eurjchem-2455	102	4	hand	hand	NOUN
eurjchem-2455	102	5	,	,	PUNCT
eurjchem-2455	102	6	it	it	PRON
eurjchem-2455	102	7	becomes	become	VERB
eurjchem-2455	102	8	very	very	ADV
eurjchem-2455	102	9	easy	easy	ADJ
eurjchem-2455	102	10	for	for	SCONJ
eurjchem-2455	102	11	an	an	DET
eurjchem-2455	102	12	electron	electron	NOUN
eurjchem-2455	102	13	to	to	PART
eurjchem-2455	102	14	jump	jump	VERB
eurjchem-2455	102	15	from	from	ADP
eurjchem-2455	102	16	homo	homo	NOUN
eurjchem-2455	102	17	to	to	ADP
eurjchem-2455	102	18	lumo	lumo	NOUN
eurjchem-2455	102	19	,	,	PUNCT
eurjchem-2455	102	20	if	if	SCONJ
eurjchem-2455	102	21	egap	egap	NOUN
eurjchem-2455	102	22	is	be	AUX
eurjchem-2455	102	23	smaller	small	ADJ
eurjchem-2455	102	24	;	;	PUNCT
eurjchem-2455	102	25	therefore	therefore	ADV
eurjchem-2455	102	26	,	,	PUNCT
eurjchem-2455	102	27	the	the	DET
eurjchem-2455	102	28	conditions	condition	NOUN
eurjchem-2455	102	29	become	become	VERB
eurjchem-2455	102	30	very	very	ADV
eurjchem-2455	102	31	easy	easy	ADJ
eurjchem-2455	102	32	for	for	SCONJ
eurjchem-2455	102	33	a	a	DET
eurjchem-2455	102	34	molecule	molecule	NOUN
eurjchem-2455	102	35	to	to	PART
eurjchem-2455	102	36	participate	participate	VERB
eurjchem-2455	102	37	in	in	ADP
eurjchem-2455	102	38	a	a	DET
eurjchem-2455	102	39	chemical	chemical	NOUN
eurjchem-2455	102	40	reaction	reaction	NOUN
eurjchem-2455	102	41	[	[	X
eurjchem-2455	102	42	24	24	NUM
eurjchem-2455	102	43	]	]	PUNCT
eurjchem-2455	102	44	.	.	PUNCT
eurjchem-2455	103	1	based	base	VERB
eurjchem-2455	103	2	on	on	ADP
eurjchem-2455	103	3	these	these	DET
eurjchem-2455	103	4	facts	fact	NOUN
eurjchem-2455	103	5	,	,	PUNCT
eurjchem-2455	103	6	pro	pro	ADJ
eurjchem-2455	103	7	-	-	ADJ
eurjchem-2455	103	8	glu	glu	ADJ
eurjchem-2455	103	9	-	-	PUNCT
eurjchem-2455	103	10	glu	glu	NOUN
eurjchem-2455	103	11	in	in	ADP
eurjchem-2455	103	12	hba	hba	NOUN
eurjchem-2455	103	13	must	must	AUX
eurjchem-2455	103	14	be	be	AUX
eurjchem-2455	103	15	less	less	ADV
eurjchem-2455	103	16	reactive	reactive	ADJ
eurjchem-2455	103	17	to	to	PART
eurjchem-2455	103	18	fit	fit	VERB
eurjchem-2455	103	19	into	into	ADP
eurjchem-2455	103	20	a	a	DET
eurjchem-2455	103	21	hydrophobic	hydrophobic	NOUN
eurjchem-2455	103	22	pocket	pocket	NOUN
eurjchem-2455	103	23	constituted	constitute	VERB
eurjchem-2455	103	24	by	by	ADP
eurjchem-2455	103	25	β88	β88	PROPN
eurjchem-2455	103	26	leucine	leucine	NOUN
eurjchem-2455	103	27	(	(	PUNCT
eurjchem-2455	103	28	leu	leu	NOUN
eurjchem-2455	103	29	-	-	PUNCT
eurjchem-2455	103	30	beta88	beta88	NOUN
eurjchem-2455	103	31	)	)	PUNCT
eurjchem-2455	103	32	,	,	PUNCT
eurjchem-2455	103	33	β85phenylalanine	β85phenylalanine	X
eurjchem-2455	103	34	(	(	PUNCT
eurjchem-2455	103	35	phe	phe	NOUN
eurjchem-2455	103	36	-	-	PUNCT
eurjchem-2455	103	37	beta85	beta85	NOUN
eurjchem-2455	103	38	)	)	PUNCT
eurjchem-2455	103	39	,	,	PUNCT
eurjchem-2455	103	40	and	and	CCONJ
eurjchem-2455	103	41	β73	β73	NOUN
eurjchem-2455	103	42	aspartic	aspartic	ADJ
eurjchem-2455	103	43	acid	acid	NOUN
eurjchem-2455	103	44	(	(	PUNCT
eurjchem-2455	103	45	aspbeta73	aspbeta73	NOUN
eurjchem-2455	103	46	)	)	PUNCT
eurjchem-2455	103	47	residues	residue	NOUN
eurjchem-2455	103	48	on	on	ADP
eurjchem-2455	103	49	adjacent	adjacent	ADJ
eurjchem-2455	103	50	dhbs	dhbs	ADJ
eurjchem-2455	103	51	-	-	PUNCT
eurjchem-2455	103	52	m.	m.	NOUN
eurjchem-2455	103	53	it	it	PRON
eurjchem-2455	103	54	is	be	AUX
eurjchem-2455	103	55	because	because	SCONJ
eurjchem-2455	103	56	its	its	PRON
eurjchem-2455	103	57	homolumo	homolumo	ADJ
eurjchem-2455	103	58	energy	energy	NOUN
eurjchem-2455	103	59	gap	gap	NOUN
eurjchem-2455	103	60	is	be	AUX
eurjchem-2455	103	61	greater	great	ADJ
eurjchem-2455	103	62	compared	compare	VERB
eurjchem-2455	103	63	to	to	ADP
eurjchem-2455	103	64	pro	pro	ADJ
eurjchem-2455	103	65	-	-	ADJ
eurjchem-2455	103	66	val	val	ADJ
eurjchem-2455	103	67	-	-	PUNCT
eurjchem-2455	103	68	glu	glu	NOUN
eurjchem-2455	103	69	(	(	PUNCT
eurjchem-2455	103	70	table	table	NOUN
eurjchem-2455	103	71	1	1	NUM
eurjchem-2455	103	72	)	)	PUNCT
eurjchem-2455	103	73	.	.	PUNCT
eurjchem-2455	104	1	on	on	ADP
eurjchem-2455	104	2	the	the	DET
eurjchem-2455	104	3	other	other	ADJ
eurjchem-2455	104	4	hand	hand	NOUN
eurjchem-2455	104	5	,	,	PUNCT
eurjchem-2455	104	6	the	the	DET
eurjchem-2455	104	7	homo	homo	NOUN
eurjchem-2455	104	8	-	-	PUNCT
eurjchem-2455	104	9	lumo	lumo	NOUN
eurjchem-2455	104	10	energy	energy	NOUN
eurjchem-2455	104	11	gap	gap	NOUN
eurjchem-2455	104	12	of	of	ADP
eurjchem-2455	104	13	pro	pro	ADJ
eurjchem-2455	104	14	-	-	ADJ
eurjchem-2455	104	15	val	val	ADJ
eurjchem-2455	104	16	-	-	PUNCT
eurjchem-2455	104	17	glu	glu	NOUN
eurjchem-2455	104	18	is	be	AUX
eurjchem-2455	104	19	lesser	less	ADJ
eurjchem-2455	104	20	than	than	ADP
eurjchem-2455	104	21	that	that	PRON
eurjchem-2455	104	22	of	of	ADP
eurjchem-2455	104	23	pro	pro	ADJ
eurjchem-2455	104	24	-	-	ADJ
eurjchem-2455	104	25	glu	glu	ADJ
eurjchem-2455	104	26	-	-	PUNCT
eurjchem-2455	104	27	glu	glu	NOUN
eurjchem-2455	104	28	(	(	PUNCT
eurjchem-2455	104	29	table	table	NOUN
eurjchem-2455	104	30	1	1	NUM
eurjchem-2455	104	31	)	)	PUNCT
eurjchem-2455	104	32	.	.	PUNCT
eurjchem-2455	105	1	therefore	therefore	ADV
eurjchem-2455	105	2	,	,	PUNCT
eurjchem-2455	105	3	pro	pro	ADJ
eurjchem-2455	105	4	-	-	ADJ
eurjchem-2455	105	5	valglu	valglu	NOUN
eurjchem-2455	105	6	in	in	ADP
eurjchem-2455	105	7	hbs	hbs	PROPN
eurjchem-2455	105	8	must	must	AUX
eurjchem-2455	105	9	be	be	AUX
eurjchem-2455	105	10	more	more	ADV
eurjchem-2455	105	11	reactive	reactive	ADJ
eurjchem-2455	105	12	to	to	PART
eurjchem-2455	105	13	fit	fit	VERB
eurjchem-2455	105	14	into	into	ADP
eurjchem-2455	105	15	a	a	DET
eurjchem-2455	105	16	hydrophobic	hydrophobic	NOUN
eurjchem-2455	105	17	pocket	pocket	NOUN
eurjchem-2455	105	18	constituted	constitute	VERB
eurjchem-2455	105	19	by	by	ADP
eurjchem-2455	105	20	β88	β88	PROPN
eurjchem-2455	105	21	leucine	leucine	NOUN
eurjchem-2455	105	22	(	(	PUNCT
eurjchem-2455	105	23	leu	leu	NOUN
eurjchem-2455	105	24	-	-	PUNCT
eurjchem-2455	105	25	beta88	beta88	NOUN
eurjchem-2455	105	26	)	)	PUNCT
eurjchem-2455	105	27	,	,	PUNCT
eurjchem-2455	105	28	β85phenylalanine	β85phenylalanine	X
eurjchem-2455	105	29	(	(	PUNCT
eurjchem-2455	105	30	phe	phe	NOUN
eurjchem-2455	105	31	-	-	PUNCT
eurjchem-2455	105	32	beta85	beta85	NOUN
eurjchem-2455	105	33	)	)	PUNCT
eurjchem-2455	105	34	,	,	PUNCT
eurjchem-2455	105	35	and	and	CCONJ
eurjchem-2455	105	36	β73	β73	NOUN
eurjchem-2455	105	37	aspartic	aspartic	ADJ
eurjchem-2455	105	38	acid	acid	NOUN
eurjchem-2455	105	39	(	(	PUNCT
eurjchem-2455	105	40	asp	asp	NOUN
eurjchem-2455	105	41	-	-	PUNCT
eurjchem-2455	105	42	beta73	beta73	NOUN
eurjchem-2455	105	43	)	)	PUNCT
eurjchem-2455	105	44	residues	residue	NOUN
eurjchem-2455	105	45	on	on	ADP
eurjchem-2455	105	46	adjacent	adjacent	ADJ
eurjchem-2455	105	47	dhbs	dhbs	ADJ
eurjchem-2455	105	48	-	-	PUNCT
eurjchem-2455	105	49	m.	m.	NOUN
eurjchem-2455	105	50	moreover	moreover	ADV
eurjchem-2455	105	51	,	,	PUNCT
eurjchem-2455	105	52	the	the	DET
eurjchem-2455	105	53	homo	homo	NOUN
eurjchem-2455	105	54	-	-	PUNCT
eurjchem-2455	105	55	lumo	lumo	NOUN
eurjchem-2455	105	56	gap	gap	NOUN
eurjchem-2455	105	57	of	of	ADP
eurjchem-2455	105	58	the	the	DET
eurjchem-2455	105	59	hydrophobic	hydrophobic	NOUN
eurjchem-2455	105	60	compound	compound	NOUN
eurjchem-2455	105	61	should	should	AUX
eurjchem-2455	105	62	be	be	AUX
eurjchem-2455	105	63	lower	low	ADJ
eurjchem-2455	105	64	for	for	ADP
eurjchem-2455	105	65	the	the	DET
eurjchem-2455	105	66	initiation	initiation	NOUN
eurjchem-2455	105	67	of	of	ADP
eurjchem-2455	105	68	the	the	DET
eurjchem-2455	105	69	polymerization	polymerization	NOUN
eurjchem-2455	105	70	reaction	reaction	NOUN
eurjchem-2455	105	71	[	[	X
eurjchem-2455	105	72	49	49	NUM
eurjchem-2455	105	73	]	]	PUNCT
eurjchem-2455	105	74	.	.	PUNCT
eurjchem-2455	106	1	therefore	therefore	ADV
eurjchem-2455	106	2	,	,	PUNCT
eurjchem-2455	106	3	the	the	DET
eurjchem-2455	106	4	reactivity	reactivity	NOUN
eurjchem-2455	106	5	of	of	ADP
eurjchem-2455	106	6	pro	pro	ADJ
eurjchem-2455	106	7	-	-	ADJ
eurjchem-2455	106	8	val	val	ADJ
eurjchem-2455	106	9	-	-	PUNCT
eurjchem-2455	106	10	glu	glu	NOUN
eurjchem-2455	106	11	to	to	PART
eurjchem-2455	106	12	fit	fit	VERB
eurjchem-2455	106	13	into	into	ADP
eurjchem-2455	106	14	the	the	DET
eurjchem-2455	106	15	hydrophobic	hydrophobic	NOUN
eurjchem-2455	106	16	pockets	pocket	NOUN
eurjchem-2455	106	17	is	be	AUX
eurjchem-2455	106	18	more	more	ADJ
eurjchem-2455	106	19	.	.	PUNCT
eurjchem-2455	107	1	now	now	ADV
eurjchem-2455	107	2	,	,	PUNCT
eurjchem-2455	107	3	the	the	DET
eurjchem-2455	107	4	reactiveness	reactiveness	NOUN
eurjchem-2455	107	5	regarding	regard	VERB
eurjchem-2455	107	6	the	the	DET
eurjchem-2455	107	7	point	point	NOUN
eurjchem-2455	107	8	between	between	ADP
eurjchem-2455	107	9	the	the	DET
eurjchem-2455	107	10	pro	pro	ADJ
eurjchem-2455	107	11	-	-	ADJ
eurjchem-2455	107	12	glu	glu	ADJ
eurjchem-2455	107	13	-	-	PUNCT
eurjchem-2455	107	14	glu	glu	NOUN
eurjchem-2455	107	15	of	of	ADP
eurjchem-2455	107	16	hba	hba	NOUN
eurjchem-2455	107	17	and	and	CCONJ
eurjchem-2455	107	18	the	the	DET
eurjchem-2455	107	19	pro	pro	ADJ
eurjchem-2455	107	20	-	-	ADJ
eurjchem-2455	107	21	val	val	ADJ
eurjchem-2455	107	22	-	-	PUNCT
eurjchem-2455	107	23	glu	glu	NOUN
eurjchem-2455	107	24	of	of	ADP
eurjchem-2455	107	25	hbs	hbs	PROPN
eurjchem-2455	107	26	to	to	PART
eurjchem-2455	107	27	fit	fit	VERB
eurjchem-2455	107	28	into	into	ADP
eurjchem-2455	107	29	hydrophobic	hydrophobic	NOUN
eurjchem-2455	107	30	points	point	NOUN
eurjchem-2455	107	31	for	for	ADP
eurjchem-2455	107	32	polymerization	polymerization	NOUN
eurjchem-2455	107	33	is	be	AUX
eurjchem-2455	107	34	resolved	resolve	VERB
eurjchem-2455	107	35	.	.	PUNCT
eurjchem-2455	108	1	another	another	DET
eurjchem-2455	108	2	reason	reason	NOUN
eurjchem-2455	108	3	for	for	ADP
eurjchem-2455	108	4	the	the	DET
eurjchem-2455	108	5	same	same	ADJ
eurjchem-2455	108	6	thing	thing	NOUN
eurjchem-2455	108	7	is	be	AUX
eurjchem-2455	108	8	the	the	DET
eurjchem-2455	108	9	hydrophobic	hydrophobic	ADJ
eurjchem-2455	108	10	nature	nature	NOUN
eurjchem-2455	108	11	of	of	ADP
eurjchem-2455	108	12	the	the	DET
eurjchem-2455	108	13	mutant	mutant	ADJ
eurjchem-2455	108	14	link	link	NOUN
eurjchem-2455	108	15	,	,	PUNCT
eurjchem-2455	108	16	i.e.	i.e.	X
eurjchem-2455	108	17	pro	pro	ADJ
eurjchem-2455	108	18	-	-	ADJ
eurjchem-2455	108	19	val	val	ADJ
eurjchem-2455	108	20	-	-	PUNCT
eurjchem-2455	108	21	glu	glu	NOUN
eurjchem-2455	108	22	.	.	PUNCT
eurjchem-2455	109	1	the	the	DET
eurjchem-2455	109	2	computationally	computationally	ADV
eurjchem-2455	109	3	evaluated	evaluate	VERB
eurjchem-2455	109	4	hydrophobicity	hydrophobicity	NOUN
eurjchem-2455	109	5	of	of	ADP
eurjchem-2455	109	6	pgg	pgg	PROPN
eurjchem-2455	109	7	and	and	CCONJ
eurjchem-2455	109	8	pvg	pvg	PROPN
eurjchem-2455	109	9	showed	show	VERB
eurjchem-2455	109	10	that	that	SCONJ
eurjchem-2455	109	11	the	the	DET
eurjchem-2455	109	12	hydrophobic	hydrophobic	ADJ
eurjchem-2455	109	13	nature	nature	NOUN
eurjchem-2455	109	14	of	of	ADP
eurjchem-2455	109	15	pvg	pvg	PROPN
eurjchem-2455	109	16	is	be	AUX
eurjchem-2455	109	17	greater	great	ADJ
eurjchem-2455	109	18	than	than	ADP
eurjchem-2455	109	19	that	that	PRON
eurjchem-2455	109	20	of	of	ADP
eurjchem-2455	109	21	pgg	pgg	PROPN
eurjchem-2455	109	22	.	.	PUNCT
eurjchem-2455	110	1	in	in	ADP
eurjchem-2455	110	2	the	the	DET
eurjchem-2455	110	3	case	case	NOUN
eurjchem-2455	110	4	of	of	ADP
eurjchem-2455	110	5	pgg	pgg	NOUN
eurjchem-2455	110	6	,	,	PUNCT
eurjchem-2455	110	7	the	the	DET
eurjchem-2455	110	8	values	value	NOUN
eurjchem-2455	110	9	of	of	ADP
eurjchem-2455	110	10	logp	logp	NOUN
eurjchem-2455	110	11	and	and	CCONJ
eurjchem-2455	110	12	clogp	clogp	ADJ
eurjchem-2455	110	13	were	be	AUX
eurjchem-2455	110	14	less	less	ADJ
eurjchem-2455	110	15	than	than	ADP
eurjchem-2455	110	16	those	those	PRON
eurjchem-2455	110	17	of	of	ADP
eurjchem-2455	110	18	pvg	pvg	PROPN
eurjchem-2455	110	19	,	,	PUNCT
eurjchem-2455	110	20	which	which	PRON
eurjchem-2455	110	21	clearly	clearly	ADV
eurjchem-2455	110	22	showed	show	VERB
eurjchem-2455	110	23	that	that	SCONJ
eurjchem-2455	110	24	pvg	pvg	NOUN
eurjchem-2455	110	25	is	be	AUX
eurjchem-2455	110	26	more	more	ADV
eurjchem-2455	110	27	hydrophobic	hydrophobic	NOUN
eurjchem-2455	110	28	than	than	ADP
eurjchem-2455	110	29	pgg	pgg	NOUN
eurjchem-2455	110	30	.	.	PUNCT
eurjchem-2455	111	1	on	on	ADP
eurjchem-2455	111	2	the	the	DET
eurjchem-2455	111	3	other	other	ADJ
eurjchem-2455	111	4	hand	hand	NOUN
eurjchem-2455	111	5	,	,	PUNCT
eurjchem-2455	111	6	the	the	DET
eurjchem-2455	111	7	values	value	NOUN
eurjchem-2455	111	8	of	of	ADP
eurjchem-2455	111	9	tpsa	tpsa	NOUN
eurjchem-2455	111	10	,	,	PUNCT
eurjchem-2455	111	11	mr	mr	PROPN
eurjchem-2455	111	12	,	,	PUNCT
eurjchem-2455	111	13	and	and	CCONJ
eurjchem-2455	111	14	cmr	cmr	NOUN
eurjchem-2455	111	15	were	be	AUX
eurjchem-2455	111	16	lower	low	ADJ
eurjchem-2455	111	17	in	in	ADP
eurjchem-2455	111	18	the	the	DET
eurjchem-2455	111	19	case	case	NOUN
eurjchem-2455	111	20	of	of	ADP
eurjchem-2455	111	21	pvg	pvg	NOUN
eurjchem-2455	111	22	than	than	ADP
eurjchem-2455	111	23	those	those	PRON
eurjchem-2455	111	24	of	of	ADP
eurjchem-2455	111	25	pgg	pgg	NOUN
eurjchem-2455	111	26	,	,	PUNCT
eurjchem-2455	111	27	and	and	CCONJ
eurjchem-2455	111	28	this	this	PRON
eurjchem-2455	111	29	also	also	ADV
eurjchem-2455	111	30	showed	show	VERB
eurjchem-2455	111	31	that	that	SCONJ
eurjchem-2455	111	32	the	the	DET
eurjchem-2455	111	33	hydrophobic	hydrophobic	ADJ
eurjchem-2455	111	34	nature	nature	NOUN
eurjchem-2455	111	35	of	of	ADP
eurjchem-2455	111	36	pvg	pvg	PROPN
eurjchem-2455	111	37	is	be	AUX
eurjchem-2455	111	38	greater	great	ADJ
eurjchem-2455	111	39	than	than	ADP
eurjchem-2455	111	40	that	that	PRON
eurjchem-2455	111	41	of	of	ADP
eurjchem-2455	111	42	pgg	pgg	PROPN
eurjchem-2455	111	43	.	.	PUNCT
eurjchem-2455	112	1	besides	besides	SCONJ
eurjchem-2455	112	2	these	these	DET
eurjchem-2455	112	3	hydrophobicity	hydrophobicity	NOUN
eurjchem-2455	112	4	-	-	PUNCT
eurjchem-2455	112	5	based	base	VERB
eurjchem-2455	112	6	things	thing	NOUN
eurjchem-2455	112	7	,	,	PUNCT
eurjchem-2455	112	8	the	the	DET
eurjchem-2455	112	9	values	value	NOUN
eurjchem-2455	112	10	of	of	ADP
eurjchem-2455	112	11	henry	henry	PROPN
eurjchem-2455	112	12	’s	’s	PART
eurjchem-2455	112	13	law	law	NOUN
eurjchem-2455	112	14	,	,	PUNCT
eurjchem-2455	112	15	the	the	DET
eurjchem-2455	112	16	heat	heat	NOUN
eurjchem-2455	112	17	of	of	ADP
eurjchem-2455	112	18	formation	formation	NOUN
eurjchem-2455	112	19	,	,	PUNCT
eurjchem-2455	112	20	clogp	clogp	ADJ
eurjchem-2455	112	21	,	,	PUNCT
eurjchem-2455	112	22	dipole	dipole	NOUN
eurjchem-2455	112	23	moment	moment	NOUN
eurjchem-2455	112	24	,	,	PUNCT
eurjchem-2455	112	25	and	and	CCONJ
eurjchem-2455	112	26	other	other	ADJ
eurjchem-2455	112	27	belongings	belonging	NOUN
eurjchem-2455	112	28	are	be	AUX
eurjchem-2455	112	29	also	also	ADV
eurjchem-2455	112	30	mentioned	mention	VERB
eurjchem-2455	112	31	in	in	ADP
eurjchem-2455	112	32	table	table	NOUN
eurjchem-2455	112	33	2	2	NUM
eurjchem-2455	112	34	.	.	PUNCT
eurjchem-2455	113	1	the	the	DET
eurjchem-2455	113	2	dipole	dipole	NOUN
eurjchem-2455	113	3	moment	moment	NOUN
eurjchem-2455	113	4	value	value	NOUN
eurjchem-2455	113	5	(	(	PUNCT
eurjchem-2455	113	6	table	table	NOUN
eurjchem-2455	113	7	2	2	NUM
eurjchem-2455	113	8	)	)	PUNCT
eurjchem-2455	113	9	of	of	ADP
eurjchem-2455	113	10	pvg	pvg	PROPN
eurjchem-2455	113	11	and	and	CCONJ
eurjchem-2455	113	12	pgg	pgg	PROPN
eurjchem-2455	113	13	clearly	clearly	ADV
eurjchem-2455	113	14	shows	show	VERB
eurjchem-2455	113	15	that	that	SCONJ
eurjchem-2455	113	16	pgg	pgg	NOUN
eurjchem-2455	113	17	is	be	AUX
eurjchem-2455	113	18	more	more	ADV
eurjchem-2455	113	19	polar	polar	ADJ
eurjchem-2455	113	20	compared	compare	VERB
eurjchem-2455	113	21	to	to	ADP
eurjchem-2455	113	22	pvg	pvg	PROPN
eurjchem-2455	113	23	.	.	PUNCT
eurjchem-2455	114	1	it	it	PRON
eurjchem-2455	114	2	is	be	AUX
eurjchem-2455	114	3	just	just	ADV
eurjchem-2455	114	4	because	because	SCONJ
eurjchem-2455	114	5	of	of	ADP
eurjchem-2455	114	6	the	the	DET
eurjchem-2455	114	7	presence	presence	NOUN
eurjchem-2455	114	8	of	of	ADP
eurjchem-2455	114	9	proline	proline	NOUN
eurjchem-2455	114	10	and	and	CCONJ
eurjchem-2455	114	11	valine	valine	NOUN
eurjchem-2455	114	12	residues	residue	NOUN
eurjchem-2455	114	13	which	which	PRON
eurjchem-2455	114	14	are	be	AUX
eurjchem-2455	114	15	nonpolar	nonpolar	ADJ
eurjchem-2455	114	16	or	or	CCONJ
eurjchem-2455	114	17	hydrophobic	hydrophobic	NOUN
eurjchem-2455	114	18	groups	group	NOUN
eurjchem-2455	114	19	[	[	X
eurjchem-2455	114	20	50	50	NUM
eurjchem-2455	114	21	]	]	PUNCT
eurjchem-2455	114	22	in	in	ADP
eurjchem-2455	114	23	pvg	pvg	PROPN
eurjchem-2455	114	24	,	,	PUNCT
eurjchem-2455	114	25	while	while	SCONJ
eurjchem-2455	114	26	glutamic	glutamic	ADJ
eurjchem-2455	114	27	acid	acid	NOUN
eurjchem-2455	114	28	is	be	AUX
eurjchem-2455	114	29	hydrophilic	hydrophilic	ADJ
eurjchem-2455	114	30	in	in	ADP
eurjchem-2455	114	31	nature	nature	NOUN
eurjchem-2455	115	1	[	[	X
eurjchem-2455	115	2	50	50	NUM
eurjchem-2455	115	3	]	]	PUNCT
eurjchem-2455	115	4	.	.	PUNCT
eurjchem-2455	116	1	on	on	ADP
eurjchem-2455	116	2	the	the	DET
eurjchem-2455	116	3	other	other	ADJ
eurjchem-2455	116	4	hand	hand	NOUN
eurjchem-2455	116	5	,	,	PUNCT
eurjchem-2455	116	6	there	there	PRON
eurjchem-2455	116	7	are	be	VERB
eurjchem-2455	116	8	two	two	NUM
eurjchem-2455	116	9	hydrophilic	hydrophilic	ADJ
eurjchem-2455	116	10	groups	group	NOUN
eurjchem-2455	116	11	(	(	PUNCT
eurjchem-2455	116	12	glutamic	glutamic	ADJ
eurjchem-2455	116	13	acid	acid	NOUN
eurjchem-2455	116	14	)	)	PUNCT
eurjchem-2455	116	15	and	and	CCONJ
eurjchem-2455	116	16	only	only	ADV
eurjchem-2455	116	17	one	one	NUM
eurjchem-2455	116	18	hydrophobic	hydrophobic	NOUN
eurjchem-2455	116	19	group	group	NOUN
eurjchem-2455	116	20	(	(	PUNCT
eurjchem-2455	116	21	proline	proline	NOUN
eurjchem-2455	116	22	)	)	PUNCT
eurjchem-2455	116	23	in	in	ADP
eurjchem-2455	116	24	the	the	DET
eurjchem-2455	116	25	pro	pro	ADJ
eurjchem-2455	116	26	-	-	ADJ
eurjchem-2455	116	27	glu	glu	ADJ
eurjchem-2455	116	28	-	-	PUNCT
eurjchem-2455	116	29	glu	glu	NOUN
eurjchem-2455	116	30	link	link	NOUN
eurjchem-2455	116	31	.	.	PUNCT
eurjchem-2455	117	1	therefore	therefore	ADV
eurjchem-2455	117	2	,	,	PUNCT
eurjchem-2455	117	3	the	the	DET
eurjchem-2455	117	4	presence	presence	NOUN
eurjchem-2455	117	5	of	of	ADP
eurjchem-2455	117	6	two	two	NUM
eurjchem-2455	117	7	hydrophobic	hydrophobic	NOUN
eurjchem-2455	117	8	amino	amino	NOUN
eurjchem-2455	117	9	acids	acid	NOUN
eurjchem-2455	117	10	in	in	ADP
eurjchem-2455	117	11	the	the	DET
eurjchem-2455	117	12	structure	structure	NOUN
eurjchem-2455	117	13	of	of	ADP
eurjchem-2455	117	14	pro	pro	ADJ
eurjchem-2455	117	15	-	-	ADJ
eurjchem-2455	117	16	val	val	ADJ
eurjchem-2455	117	17	-	-	PUNCT
eurjchem-2455	117	18	glu	glu	NOUN
eurjchem-2455	117	19	makes	make	VERB
eurjchem-2455	117	20	it	it	PRON
eurjchem-2455	117	21	hydrophobic	hydrophobic	VERB
eurjchem-2455	117	22	.	.	PUNCT
eurjchem-2455	118	1	suhail	suhail	PROPN
eurjchem-2455	118	2	et	et	PROPN
eurjchem-2455	118	3	al	al	PROPN
eurjchem-2455	118	4	.	.	PUNCT
eurjchem-2455	118	5	/	/	SYM
eurjchem-2455	118	6	european	european	PROPN
eurjchem-2455	118	7	journal	journal	PROPN
eurjchem-2455	118	8	of	of	ADP
eurjchem-2455	118	9	chemistry	chemistry	NOUN
eurjchem-2455	118	10	14	14	NUM
eurjchem-2455	118	11	(	(	PUNCT
eurjchem-2455	118	12	3	3	NUM
eurjchem-2455	118	13	)	)	PUNCT
eurjchem-2455	118	14	(	(	PUNCT
eurjchem-2455	118	15	2023	2023	NUM
eurjchem-2455	118	16	)	)	PUNCT
eurjchem-2455	118	17	370	370	NUM
eurjchem-2455	118	18	-	-	SYM
eurjchem-2455	118	19	375	375	NUM
eurjchem-2455	118	20	373	373	NUM
eurjchem-2455	118	21	2023	2023	NUM
eurjchem-2455	118	22	–	–	PUNCT
eurjchem-2455	118	23	european	european	ADJ
eurjchem-2455	118	24	journal	journal	NOUN
eurjchem-2455	118	25	of	of	ADP
eurjchem-2455	118	26	chemistry	chemistry	NOUN
eurjchem-2455	118	27	–	–	PUNCT
eurjchem-2455	118	28	cc	cc	NOUN
eurjchem-2455	118	29	by	by	ADP
eurjchem-2455	118	30	nc	nc	PROPN
eurjchem-2455	118	31	–	–	PUNCT
eurjchem-2455	118	32	doi	doi	NOUN
eurjchem-2455	118	33	:	:	PUNCT
eurjchem-2455	118	34	10.5155	10.5155	NUM
eurjchem-2455	118	35	/	/	SYM
eurjchem-2455	118	36	eurjchem.14.3.370	eurjchem.14.3.370	NOUN
eurjchem-2455	118	37	-	-	PUNCT
eurjchem-2455	118	38	375.2455	375.2455	NUM
eurjchem-2455	118	39	table	table	NOUN
eurjchem-2455	118	40	2	2	NUM
eurjchem-2455	118	41	.	.	PUNCT
eurjchem-2455	119	1	parameters	parameter	NOUN
eurjchem-2455	119	2	computed	compute	VERB
eurjchem-2455	119	3	to	to	PART
eurjchem-2455	119	4	distinguish	distinguish	VERB
eurjchem-2455	119	5	the	the	DET
eurjchem-2455	119	6	nature	nature	NOUN
eurjchem-2455	119	7	of	of	ADP
eurjchem-2455	119	8	pgg	pgg	PROPN
eurjchem-2455	119	9	and	and	CCONJ
eurjchem-2455	119	10	pvg	pvg	PROPN
eurjchem-2455	119	11	.	.	PUNCT
eurjchem-2455	120	1	software	software	NOUN
eurjchem-2455	120	2	parameters	parameter	NOUN
eurjchem-2455	120	3	pgg	pgg	PROPN
eurjchem-2455	120	4	pvg	pvg	PROPN
eurjchem-2455	120	5	chemdraw	chemdraw	PROPN
eurjchem-2455	120	6	gibbs	gibbs	PROPN
eurjchem-2455	120	7	energy	energy	PROPN
eurjchem-2455	120	8	,	,	PUNCT
eurjchem-2455	120	9	kj	kj	PROPN
eurjchem-2455	120	10	/	/	SYM
eurjchem-2455	120	11	mol	mol	ADP
eurjchem-2455	121	1	-955.09	-955.09	PROPN
eurjchem-2455	122	1	-613.62	-613.62	PROPN
eurjchem-2455	123	1	henry	henry	PROPN
eurjchem-2455	123	2	’s	’s	PART
eurjchem-2455	123	3	law	law	NOUN
eurjchem-2455	123	4	31.12	31.12	NUM
eurjchem-2455	123	5	25.87	25.87	NUM
eurjchem-2455	123	6	heat	heat	NOUN
eurjchem-2455	123	7	of	of	ADP
eurjchem-2455	123	8	form	form	NOUN
eurjchem-2455	123	9	,	,	PUNCT
eurjchem-2455	123	10	kj	kj	PROPN
eurjchem-2455	123	11	/	/	SYM
eurjchem-2455	123	12	mol	mol	ADP
eurjchem-2455	123	13	-1540.43	-1540.43	PROPN
eurjchem-2455	123	14	-1195.44	-1195.44	PROPN
eurjchem-2455	123	15	tpsa	tpsa	NOUN
eurjchem-2455	123	16	182.13	182.13	NUM
eurjchem-2455	123	17	144.83	144.83	NUM
eurjchem-2455	123	18	log	log	NOUN
eurjchem-2455	123	19	p	p	NOUN
eurjchem-2455	123	20	-2.71	-2.71	NUM
eurjchem-2455	123	21	-1.32	-1.32	ADJ
eurjchem-2455	123	22	clogp	clogp	ADJ
eurjchem-2455	123	23	-4.4154	-4.4154	NOUN
eurjchem-2455	123	24	-2.5994	-2.5994	X
eurjchem-2455	124	1	mr	mr	PROPN
eurjchem-2455	124	2	,	,	PUNCT
eurjchem-2455	124	3	cm3	cm3	PROPN
eurjchem-2455	124	4	/	/	SYM
eurjchem-2455	124	5	mol	mol	ADP
eurjchem-2455	124	6	83.69	83.69	NUM
eurjchem-2455	124	7	83.24	83.24	NUM
eurjchem-2455	124	8	cmr	cmr	PROPN
eurjchem-2455	124	9	8.7009	8.7009	NUM
eurjchem-2455	124	10	8.5121	8.5121	NUM
eurjchem-2455	124	11	gaussian	gaussian	NOUN
eurjchem-2455	124	12	03	03	NUM
eurjchem-2455	124	13	electronic	electronic	ADJ
eurjchem-2455	124	14	energy	energy	NOUN
eurjchem-2455	124	15	,	,	PUNCT
eurjchem-2455	124	16	a.u	a.u	PROPN
eurjchem-2455	124	17	.	.	PROPN
eurjchem-2455	124	18	-1344.39	-1344.39	NUM
eurjchem-2455	124	19	-1195.92	-1195.92	PROPN
eurjchem-2455	124	20	dipole	dipole	NOUN
eurjchem-2455	124	21	moment	moment	NOUN
eurjchem-2455	124	22	,	,	PUNCT
eurjchem-2455	124	23	debye	debye	ADJ
eurjchem-2455	124	24	9.5386	9.5386	NUM
eurjchem-2455	124	25	8.2611	8.2611	NUM
eurjchem-2455	124	26	lumo	lumo	NOUN
eurjchem-2455	124	27	lumo	lumo	NOUN
eurjchem-2455	124	28	homo	homo	NOUN
eurjchem-2455	124	29	homo	homo	NOUN
eurjchem-2455	124	30	(	(	PUNCT
eurjchem-2455	124	31	a	a	NOUN
eurjchem-2455	124	32	)	)	PUNCT
eurjchem-2455	124	33	(	(	PUNCT
eurjchem-2455	124	34	b	b	X
eurjchem-2455	124	35	)	)	PUNCT
eurjchem-2455	124	36	figure	figure	NOUN
eurjchem-2455	124	37	3	3	NUM
eurjchem-2455	124	38	.	.	PUNCT
eurjchem-2455	125	1	homo	homo	NOUN
eurjchem-2455	125	2	-	-	PUNCT
eurjchem-2455	125	3	lumo	lumo	NOUN
eurjchem-2455	125	4	of	of	ADP
eurjchem-2455	125	5	(	(	PUNCT
eurjchem-2455	125	6	a	a	PRON
eurjchem-2455	125	7	)	)	PUNCT
eurjchem-2455	125	8	pgg	pgg	NOUN
eurjchem-2455	125	9	(	(	PUNCT
eurjchem-2455	125	10	hba	hba	PROPN
eurjchem-2455	125	11	)	)	PUNCT
eurjchem-2455	125	12	and	and	CCONJ
eurjchem-2455	125	13	(	(	PUNCT
eurjchem-2455	125	14	b	b	X
eurjchem-2455	125	15	)	)	PUNCT
eurjchem-2455	125	16	pvg	pvg	NOUN
eurjchem-2455	125	17	(	(	PUNCT
eurjchem-2455	125	18	hbs	hbs	PROPN
eurjchem-2455	125	19	)	)	PUNCT
eurjchem-2455	125	20	after	after	ADP
eurjchem-2455	125	21	dft	dft	NOUN
eurjchem-2455	125	22	and	and	CCONJ
eurjchem-2455	125	23	hartree	hartree	ADJ
eurjchem-2455	125	24	fock	fock	ADJ
eurjchem-2455	125	25	calculation	calculation	NOUN
eurjchem-2455	125	26	.	.	PUNCT
eurjchem-2455	126	1	on	on	ADP
eurjchem-2455	126	2	the	the	DET
eurjchem-2455	126	3	other	other	ADJ
eurjchem-2455	126	4	hand	hand	NOUN
eurjchem-2455	126	5	,	,	PUNCT
eurjchem-2455	126	6	the	the	DET
eurjchem-2455	126	7	binding	bind	VERB
eurjchem-2455	126	8	sites	site	NOUN
eurjchem-2455	126	9	i.e.	i.e.	X
eurjchem-2455	126	10	β88	β88	PROPN
eurjchem-2455	126	11	leucine	leucine	NOUN
eurjchem-2455	126	12	(	(	PUNCT
eurjchem-2455	126	13	leubeta88	leubeta88	NOUN
eurjchem-2455	126	14	)	)	PUNCT
eurjchem-2455	126	15	,	,	PUNCT
eurjchem-2455	126	16	β85phenylalanine	β85phenylalanine	X
eurjchem-2455	126	17	(	(	PUNCT
eurjchem-2455	126	18	phe	phe	NOUN
eurjchem-2455	126	19	-	-	PUNCT
eurjchem-2455	126	20	beta85	beta85	NOUN
eurjchem-2455	126	21	)	)	PUNCT
eurjchem-2455	126	22	,	,	PUNCT
eurjchem-2455	126	23	and	and	CCONJ
eurjchem-2455	126	24	β73	β73	NOUN
eurjchem-2455	126	25	aspartic	aspartic	ADJ
eurjchem-2455	126	26	acid	acid	NOUN
eurjchem-2455	126	27	(	(	PUNCT
eurjchem-2455	126	28	asp	asp	NOUN
eurjchem-2455	126	29	-	-	PUNCT
eurjchem-2455	126	30	beta73	beta73	NOUN
eurjchem-2455	126	31	)	)	PUNCT
eurjchem-2455	126	32	residues	residue	NOUN
eurjchem-2455	126	33	on	on	ADP
eurjchem-2455	126	34	the	the	DET
eurjchem-2455	126	35	adjacent	adjacent	ADJ
eurjchem-2455	126	36	dhbs	dhb	NOUN
eurjchem-2455	126	37	-	-	PUNCT
eurjchem-2455	126	38	m	m	NOUN
eurjchem-2455	126	39	are	be	AUX
eurjchem-2455	126	40	also	also	ADV
eurjchem-2455	126	41	hydrophobic	hydrophobic	ADJ
eurjchem-2455	126	42	[	[	X
eurjchem-2455	126	43	7,10,11	7,10,11	NUM
eurjchem-2455	126	44	]	]	PUNCT
eurjchem-2455	126	45	.	.	PUNCT
eurjchem-2455	127	1	hence	hence	ADV
eurjchem-2455	127	2	,	,	PUNCT
eurjchem-2455	127	3	the	the	DET
eurjchem-2455	127	4	attachment	attachment	NOUN
eurjchem-2455	127	5	of	of	ADP
eurjchem-2455	127	6	hydrophobic	hydrophobic	ADJ
eurjchem-2455	127	7	pro	pro	ADJ
eurjchem-2455	127	8	-	-	ADJ
eurjchem-2455	127	9	val	val	ADJ
eurjchem-2455	127	10	-	-	PUNCT
eurjchem-2455	127	11	glu	glu	NOUN
eurjchem-2455	127	12	of	of	ADP
eurjchem-2455	127	13	hbs	hbs	PROPN
eurjchem-2455	127	14	with	with	ADP
eurjchem-2455	127	15	the	the	DET
eurjchem-2455	127	16	hydrophobic	hydrophobic	NOUN
eurjchem-2455	127	17	residues	residue	NOUN
eurjchem-2455	127	18	of	of	ADP
eurjchem-2455	127	19	the	the	DET
eurjchem-2455	127	20	adjacent	adjacent	ADJ
eurjchem-2455	127	21	dhbs	dhb	NOUN
eurjchem-2455	127	22	-	-	PUNCT
eurjchem-2455	127	23	m	m	NOUN
eurjchem-2455	127	24	is	be	AUX
eurjchem-2455	127	25	stronger	strong	ADJ
eurjchem-2455	127	26	compared	compare	VERB
eurjchem-2455	127	27	to	to	ADP
eurjchem-2455	127	28	that	that	PRON
eurjchem-2455	127	29	of	of	ADP
eurjchem-2455	127	30	hydrophilic	hydrophilic	ADJ
eurjchem-2455	127	31	pro	pro	ADJ
eurjchem-2455	127	32	-	-	ADJ
eurjchem-2455	127	33	glu	glu	ADJ
eurjchem-2455	127	34	-	-	PUNCT
eurjchem-2455	127	35	glu	glu	NOUN
eurjchem-2455	127	36	of	of	ADP
eurjchem-2455	127	37	hba	hba	NOUN
eurjchem-2455	127	38	.	.	PUNCT
eurjchem-2455	128	1	it	it	PRON
eurjchem-2455	128	2	is	be	AUX
eurjchem-2455	128	3	because	because	SCONJ
eurjchem-2455	128	4	the	the	DET
eurjchem-2455	128	5	hydrophilic	hydrophilic	ADJ
eurjchem-2455	128	6	compound	compound	NOUN
eurjchem-2455	128	7	does	do	AUX
eurjchem-2455	128	8	not	not	PART
eurjchem-2455	128	9	have	have	VERB
eurjchem-2455	128	10	a	a	DET
eurjchem-2455	128	11	greater	great	ADJ
eurjchem-2455	128	12	affinity	affinity	NOUN
eurjchem-2455	128	13	towards	towards	ADP
eurjchem-2455	128	14	the	the	DET
eurjchem-2455	128	15	hydrophobic	hydrophobic	NOUN
eurjchem-2455	128	16	complex	complex	NOUN
eurjchem-2455	128	17	,	,	PUNCT
eurjchem-2455	128	18	but	but	CCONJ
eurjchem-2455	128	19	the	the	DET
eurjchem-2455	128	20	hydrophobic	hydrophobic	NOUN
eurjchem-2455	128	21	compound	compound	NOUN
eurjchem-2455	128	22	does	do	AUX
eurjchem-2455	128	23	according	accord	VERB
eurjchem-2455	128	24	to	to	ADP
eurjchem-2455	128	25	the	the	DET
eurjchem-2455	128	26	universal	universal	ADJ
eurjchem-2455	128	27	truth	truth	NOUN
eurjchem-2455	128	28	.	.	PUNCT
eurjchem-2455	129	1	hence	hence	ADV
eurjchem-2455	129	2	,	,	PUNCT
eurjchem-2455	129	3	there	there	PRON
eurjchem-2455	129	4	are	be	VERB
eurjchem-2455	129	5	two	two	NUM
eurjchem-2455	129	6	factors	factor	NOUN
eurjchem-2455	129	7	associated	associate	VERB
eurjchem-2455	129	8	with	with	ADP
eurjchem-2455	129	9	pro	pro	ADJ
eurjchem-2455	129	10	-	-	ADJ
eurjchem-2455	129	11	val	val	ADJ
eurjchem-2455	129	12	-	-	PUNCT
eurjchem-2455	129	13	glu	glu	NOUN
eurjchem-2455	129	14	before	before	ADP
eurjchem-2455	129	15	polymerization	polymerization	NOUN
eurjchem-2455	129	16	under	under	ADP
eurjchem-2455	129	17	hypoxia	hypoxia	NOUN
eurjchem-2455	129	18	conditions	condition	NOUN
eurjchem-2455	129	19	:	:	PUNCT
eurjchem-2455	129	20	(	(	PUNCT
eurjchem-2455	129	21	i	i	NOUN
eurjchem-2455	129	22	)	)	PUNCT
eurjchem-2455	129	23	the	the	DET
eurjchem-2455	129	24	decreased	decrease	VERB
eurjchem-2455	129	25	egap	egap	NOUN
eurjchem-2455	129	26	value	value	NOUN
eurjchem-2455	129	27	of	of	ADP
eurjchem-2455	129	28	pro	pro	ADJ
eurjchem-2455	129	29	-	-	ADJ
eurjchem-2455	129	30	val	val	ADJ
eurjchem-2455	129	31	-	-	PUNCT
eurjchem-2455	129	32	glu	glu	NOUN
eurjchem-2455	129	33	for	for	ADP
eurjchem-2455	129	34	its	its	PRON
eurjchem-2455	129	35	quick	quick	ADJ
eurjchem-2455	129	36	participation	participation	NOUN
eurjchem-2455	129	37	in	in	ADP
eurjchem-2455	129	38	the	the	DET
eurjchem-2455	129	39	reaction	reaction	NOUN
eurjchem-2455	129	40	,	,	PUNCT
eurjchem-2455	129	41	and	and	CCONJ
eurjchem-2455	129	42	(	(	PUNCT
eurjchem-2455	129	43	ii	ii	NOUN
eurjchem-2455	129	44	)	)	PUNCT
eurjchem-2455	129	45	its	its	PRON
eurjchem-2455	129	46	hydrophobic	hydrophobic	NOUN
eurjchem-2455	129	47	nature	nature	NOUN
eurjchem-2455	129	48	.	.	PUNCT
eurjchem-2455	130	1	these	these	DET
eurjchem-2455	130	2	two	two	NUM
eurjchem-2455	130	3	factors	factor	NOUN
eurjchem-2455	130	4	are	be	AUX
eurjchem-2455	130	5	responsible	responsible	ADJ
eurjchem-2455	130	6	for	for	ADP
eurjchem-2455	130	7	the	the	DET
eurjchem-2455	130	8	generation	generation	NOUN
eurjchem-2455	130	9	of	of	ADP
eurjchem-2455	130	10	a	a	DET
eurjchem-2455	130	11	‘	'	PUNCT
eurjchem-2455	130	12	sticky	sticky	ADJ
eurjchem-2455	130	13	patch	patch	NOUN
eurjchem-2455	130	14	’	'	PUNCT
eurjchem-2455	130	15	on	on	ADP
eurjchem-2455	130	16	the	the	DET
eurjchem-2455	130	17	β	β	NOUN
eurjchem-2455	130	18	-	-	ADJ
eurjchem-2455	130	19	globin	globin	ADJ
eurjchem-2455	130	20	chains	chain	NOUN
eurjchem-2455	130	21	of	of	ADP
eurjchem-2455	130	22	dhbs	dhbs	ADJ
eurjchem-2455	130	23	-	-	PUNCT
eurjchem-2455	130	24	m	m	NOUN
eurjchem-2455	130	25	[	[	X
eurjchem-2455	130	26	7,10,11	7,10,11	NUM
eurjchem-2455	130	27	]	]	PUNCT
eurjchem-2455	130	28	.	.	PUNCT
eurjchem-2455	131	1	4	4	X
eurjchem-2455	131	2	.	.	X
eurjchem-2455	131	3	gaps	gap	NOUN
eurjchem-2455	131	4	in	in	ADP
eurjchem-2455	131	5	the	the	DET
eurjchem-2455	131	6	development	development	NOUN
eurjchem-2455	131	7	of	of	ADP
eurjchem-2455	131	8	anti	anti	ADJ
eurjchem-2455	131	9	-	-	ADJ
eurjchem-2455	131	10	sickling	sickling	ADJ
eurjchem-2455	131	11	agents	agent	NOUN
eurjchem-2455	131	12	after	after	ADP
eurjchem-2455	131	13	a	a	DET
eurjchem-2455	131	14	literature	literature	NOUN
eurjchem-2455	131	15	survey	survey	NOUN
eurjchem-2455	131	16	,	,	PUNCT
eurjchem-2455	131	17	it	it	PRON
eurjchem-2455	131	18	was	be	AUX
eurjchem-2455	131	19	found	find	VERB
eurjchem-2455	131	20	that	that	SCONJ
eurjchem-2455	131	21	the	the	DET
eurjchem-2455	131	22	development	development	NOUN
eurjchem-2455	131	23	of	of	ADP
eurjchem-2455	131	24	antisickling	antisickle	VERB
eurjchem-2455	131	25	agents	agent	NOUN
eurjchem-2455	131	26	has	have	VERB
eurjchem-2455	131	27	a	a	DET
eurjchem-2455	131	28	large	large	ADJ
eurjchem-2455	131	29	gap	gap	NOUN
eurjchem-2455	131	30	to	to	PART
eurjchem-2455	131	31	be	be	AUX
eurjchem-2455	131	32	more	more	ADV
eurjchem-2455	131	33	potent	potent	ADJ
eurjchem-2455	131	34	.	.	PUNCT
eurjchem-2455	132	1	here	here	ADV
eurjchem-2455	132	2	are	be	AUX
eurjchem-2455	132	3	some	some	DET
eurjchem-2455	132	4	important	important	ADJ
eurjchem-2455	132	5	gaps	gap	NOUN
eurjchem-2455	132	6	observed	observe	VERB
eurjchem-2455	132	7	during	during	ADP
eurjchem-2455	132	8	the	the	DET
eurjchem-2455	132	9	literature	literature	NOUN
eurjchem-2455	132	10	survey	survey	NOUN
eurjchem-2455	132	11	,	,	PUNCT
eurjchem-2455	132	12	as	as	SCONJ
eurjchem-2455	132	13	follows	follow	VERB
eurjchem-2455	132	14	:	:	PUNCT
eurjchem-2455	132	15	i.	i.	PROPN
eurjchem-2455	132	16	according	accord	VERB
eurjchem-2455	132	17	to	to	ADP
eurjchem-2455	132	18	data	datum	NOUN
eurjchem-2455	132	19	from	from	ADP
eurjchem-2455	132	20	the	the	DET
eurjchem-2455	132	21	literature	literature	NOUN
eurjchem-2455	132	22	,	,	PUNCT
eurjchem-2455	132	23	polymerization	polymerization	NOUN
eurjchem-2455	132	24	occurs	occur	VERB
eurjchem-2455	132	25	under	under	ADP
eurjchem-2455	132	26	hypoxia	hypoxia	NOUN
eurjchem-2455	132	27	conditions	condition	NOUN
eurjchem-2455	132	28	[	[	X
eurjchem-2455	132	29	3,5	3,5	NUM
eurjchem-2455	132	30	]	]	PUNCT
eurjchem-2455	132	31	,	,	PUNCT
eurjchem-2455	132	32	so	so	ADV
eurjchem-2455	132	33	most	most	ADJ
eurjchem-2455	132	34	scientists	scientist	NOUN
eurjchem-2455	132	35	synthesize	synthesize	VERB
eurjchem-2455	132	36	only	only	ADV
eurjchem-2455	132	37	those	those	DET
eurjchem-2455	132	38	drugs	drug	NOUN
eurjchem-2455	132	39	or	or	CCONJ
eurjchem-2455	132	40	their	their	PRON
eurjchem-2455	132	41	derivatives	derivative	NOUN
eurjchem-2455	132	42	that	that	PRON
eurjchem-2455	132	43	could	could	AUX
eurjchem-2455	132	44	stabilize	stabilize	VERB
eurjchem-2455	132	45	oxy	oxy	PROPN
eurjchem-2455	132	46	hbs	hbs	PROPN
eurjchem-2455	133	1	[	[	X
eurjchem-2455	133	2	13	13	NUM
eurjchem-2455	133	3	-	-	SYM
eurjchem-2455	133	4	18	18	NUM
eurjchem-2455	133	5	]	]	PUNCT
eurjchem-2455	133	6	,	,	PUNCT
eurjchem-2455	133	7	so	so	SCONJ
eurjchem-2455	133	8	that	that	DET
eurjchem-2455	133	9	polymerization	polymerization	NOUN
eurjchem-2455	133	10	could	could	AUX
eurjchem-2455	133	11	be	be	AUX
eurjchem-2455	133	12	stopped	stop	VERB
eurjchem-2455	133	13	.	.	PUNCT
eurjchem-2455	134	1	for	for	ADP
eurjchem-2455	134	2	example	example	NOUN
eurjchem-2455	134	3	,	,	PUNCT
eurjchem-2455	134	4	vanillin	vanillin	PROPN
eurjchem-2455	134	5	stabilizes	stabilize	VERB
eurjchem-2455	134	6	oxy	oxy	PROPN
eurjchem-2455	134	7	hbs	hbs	PROPN
eurjchem-2455	134	8	and	and	CCONJ
eurjchem-2455	134	9	stops	stop	VERB
eurjchem-2455	134	10	the	the	DET
eurjchem-2455	134	11	polymerization	polymerization	NOUN
eurjchem-2455	134	12	of	of	ADP
eurjchem-2455	134	13	hbs	hbs	PROPN
eurjchem-2455	134	14	to	to	ADP
eurjchem-2455	134	15	some	some	DET
eurjchem-2455	134	16	extent	extent	NOUN
eurjchem-2455	134	17	,	,	PUNCT
eurjchem-2455	134	18	but	but	CCONJ
eurjchem-2455	134	19	not	not	PART
eurjchem-2455	134	20	100	100	NUM
eurjchem-2455	134	21	%	%	NOUN
eurjchem-2455	134	22	.	.	PUNCT
eurjchem-2455	135	1	although	although	SCONJ
eurjchem-2455	135	2	other	other	ADJ
eurjchem-2455	135	3	drugs	drug	NOUN
eurjchem-2455	135	4	having	have	VERB
eurjchem-2455	135	5	structural	structural	ADJ
eurjchem-2455	135	6	differences	difference	NOUN
eurjchem-2455	135	7	with	with	ADP
eurjchem-2455	135	8	vanillin	vanillin	NOUN
eurjchem-2455	135	9	were	be	AUX
eurjchem-2455	135	10	also	also	ADV
eurjchem-2455	135	11	suggested	suggest	VERB
eurjchem-2455	135	12	[	[	X
eurjchem-2455	135	13	51	51	NUM
eurjchem-2455	135	14	]	]	PUNCT
eurjchem-2455	135	15	,	,	PUNCT
eurjchem-2455	135	16	those	those	DET
eurjchem-2455	135	17	drugs	drug	NOUN
eurjchem-2455	135	18	were	be	AUX
eurjchem-2455	135	19	also	also	ADV
eurjchem-2455	135	20	used	use	VERB
eurjchem-2455	135	21	just	just	ADV
eurjchem-2455	135	22	to	to	PART
eurjchem-2455	135	23	increase	increase	VERB
eurjchem-2455	135	24	the	the	DET
eurjchem-2455	135	25	stability	stability	NOUN
eurjchem-2455	135	26	of	of	ADP
eurjchem-2455	135	27	oxy	oxy	PROPN
eurjchem-2455	135	28	hbs	hbs	PROPN
eurjchem-2455	135	29	.	.	PUNCT
eurjchem-2455	136	1	no	no	DET
eurjchem-2455	136	2	one	one	NOUN
eurjchem-2455	136	3	focused	focus	VERB
eurjchem-2455	136	4	on	on	ADP
eurjchem-2455	136	5	the	the	DET
eurjchem-2455	136	6	synthesis	synthesis	NOUN
eurjchem-2455	136	7	of	of	ADP
eurjchem-2455	136	8	such	such	DET
eurjchem-2455	136	9	a	a	DET
eurjchem-2455	136	10	drug	drug	NOUN
eurjchem-2455	136	11	that	that	PRON
eurjchem-2455	136	12	could	could	AUX
eurjchem-2455	136	13	work	work	VERB
eurjchem-2455	136	14	under	under	ADP
eurjchem-2455	136	15	hypoxia	hypoxia	NOUN
eurjchem-2455	136	16	conditions	condition	NOUN
eurjchem-2455	136	17	.	.	PUNCT
eurjchem-2455	137	1	ii	ii	X
eurjchem-2455	137	2	.	.	PUNCT
eurjchem-2455	138	1	antisickling	antisickle	VERB
eurjchem-2455	138	2	drugs	drug	NOUN
eurjchem-2455	138	3	synthesized	synthesize	VERB
eurjchem-2455	138	4	[	[	PUNCT
eurjchem-2455	138	5	13	13	NUM
eurjchem-2455	138	6	-	-	SYM
eurjchem-2455	138	7	18	18	NUM
eurjchem-2455	138	8	]	]	PUNCT
eurjchem-2455	138	9	or	or	CCONJ
eurjchem-2455	138	10	available	available	ADJ
eurjchem-2455	138	11	on	on	ADP
eurjchem-2455	138	12	the	the	DET
eurjchem-2455	138	13	market	market	NOUN
eurjchem-2455	138	14	(	(	PUNCT
eurjchem-2455	138	15	figure	figure	NOUN
eurjchem-2455	138	16	1a	1a	NOUN
eurjchem-2455	138	17	)	)	PUNCT
eurjchem-2455	138	18	attack	attack	NOUN
eurjchem-2455	138	19	only	only	ADV
eurjchem-2455	138	20	the	the	DET
eurjchem-2455	138	21	alpha	alpha	NOUN
eurjchem-2455	138	22	chain	chain	NOUN
eurjchem-2455	138	23	of	of	ADP
eurjchem-2455	138	24	hemoglobin	hemoglobin	NOUN
eurjchem-2455	138	25	(	(	PUNCT
eurjchem-2455	138	26	figure	figure	NOUN
eurjchem-2455	138	27	1b	1b	NUM
eurjchem-2455	138	28	)	)	PUNCT
eurjchem-2455	138	29	,	,	PUNCT
eurjchem-2455	138	30	while	while	SCONJ
eurjchem-2455	138	31	the	the	DET
eurjchem-2455	138	32	mutation	mutation	NOUN
eurjchem-2455	138	33	-	-	PUNCT
eurjchem-2455	138	34	causing	cause	VERB
eurjchem-2455	138	35	residue	residue	NOUN
eurjchem-2455	138	36	is	be	AUX
eurjchem-2455	138	37	present	present	ADJ
eurjchem-2455	138	38	on	on	ADP
eurjchem-2455	138	39	the	the	DET
eurjchem-2455	138	40	beta	beta	NOUN
eurjchem-2455	138	41	chain	chain	NOUN
eurjchem-2455	138	42	of	of	ADP
eurjchem-2455	138	43	hemoglobin	hemoglobin	NOUN
eurjchem-2455	138	44	.	.	PUNCT
eurjchem-2455	139	1	hence	hence	ADV
eurjchem-2455	139	2	,	,	PUNCT
eurjchem-2455	139	3	no	no	DET
eurjchem-2455	139	4	such	such	ADJ
eurjchem-2455	139	5	drug	drug	NOUN
eurjchem-2455	139	6	has	have	AUX
eurjchem-2455	139	7	been	be	AUX
eurjchem-2455	139	8	found	find	VERB
eurjchem-2455	139	9	/	/	PUNCT
eurjchem-2455	139	10	synthesized	synthesize	VERB
eurjchem-2455	139	11	yet	yet	ADV
eurjchem-2455	139	12	that	that	PRON
eurjchem-2455	139	13	could	could	AUX
eurjchem-2455	139	14	show	show	VERB
eurjchem-2455	139	15	affinity	affinity	NOUN
eurjchem-2455	139	16	to	to	PART
eurjchem-2455	139	17	attach	attach	VERB
eurjchem-2455	139	18	to	to	ADP
eurjchem-2455	139	19	the	the	DET
eurjchem-2455	139	20	β	β	NOUN
eurjchem-2455	139	21	-	-	NOUN
eurjchem-2455	139	22	chain	chain	NOUN
eurjchem-2455	139	23	of	of	ADP
eurjchem-2455	139	24	hemoglobin	hemoglobin	NOUN
eurjchem-2455	139	25	.	.	PUNCT
eurjchem-2455	140	1	iii	iii	X
eurjchem-2455	140	2	.	.	PUNCT
eurjchem-2455	141	1	antisickling	antisickle	VERB
eurjchem-2455	141	2	drugs	drug	NOUN
eurjchem-2455	141	3	synthesized	synthesize	VERB
eurjchem-2455	141	4	[	[	PUNCT
eurjchem-2455	141	5	13	13	NUM
eurjchem-2455	141	6	-	-	SYM
eurjchem-2455	141	7	18	18	NUM
eurjchem-2455	141	8	]	]	PUNCT
eurjchem-2455	141	9	or	or	CCONJ
eurjchem-2455	141	10	available	available	ADJ
eurjchem-2455	141	11	on	on	ADP
eurjchem-2455	141	12	the	the	DET
eurjchem-2455	141	13	market	market	NOUN
eurjchem-2455	141	14	(	(	PUNCT
eurjchem-2455	141	15	figure	figure	NOUN
eurjchem-2455	141	16	1a	1a	NOUN
eurjchem-2455	141	17	)	)	PUNCT
eurjchem-2455	141	18	react	react	VERB
eurjchem-2455	141	19	with	with	ADP
eurjchem-2455	141	20	only	only	ADV
eurjchem-2455	141	21	hb	hb	NOUN
eurjchem-2455	141	22	αval1	αval1	ADJ
eurjchem-2455	141	23	amines	amine	NOUN
eurjchem-2455	141	24	to	to	PART
eurjchem-2455	141	25	form	form	VERB
eurjchem-2455	141	26	schiff	schiff	NOUN
eurjchem-2455	141	27	base	base	NOUN
eurjchem-2455	141	28	adducts	adduct	NOUN
eurjchem-2455	141	29	(	(	PUNCT
eurjchem-2455	141	30	figure	figure	NOUN
eurjchem-2455	141	31	1b	1b	NUM
eurjchem-2455	141	32	)	)	PUNCT
eurjchem-2455	141	33	,	,	PUNCT
eurjchem-2455	141	34	but	but	CCONJ
eurjchem-2455	141	35	what	what	PRON
eurjchem-2455	141	36	about	about	ADP
eurjchem-2455	141	37	β	β	X
eurjchem-2455	141	38	valine	valine	X
eurjchem-2455	141	39	(	(	PUNCT
eurjchem-2455	141	40	valbeta6	valbeta6	NOUN
eurjchem-2455	141	41	)	)	PUNCT
eurjchem-2455	141	42	whose	whose	DET
eurjchem-2455	141	43	presence	presence	NOUN
eurjchem-2455	141	44	causes	cause	VERB
eurjchem-2455	141	45	polymerization	polymerization	NOUN
eurjchem-2455	141	46	?	?	PUNCT
eurjchem-2455	142	1	therefore	therefore	ADV
eurjchem-2455	142	2	,	,	PUNCT
eurjchem-2455	142	3	no	no	DET
eurjchem-2455	142	4	such	such	ADJ
eurjchem-2455	142	5	drug	drug	NOUN
eurjchem-2455	142	6	has	have	AUX
eurjchem-2455	142	7	yet	yet	ADV
eurjchem-2455	142	8	been	be	AUX
eurjchem-2455	142	9	found	find	VERB
eurjchem-2455	142	10	/	/	PUNCT
eurjchem-2455	142	11	synthesized	synthesize	VERB
eurjchem-2455	142	12	that	that	PRON
eurjchem-2455	142	13	could	could	AUX
eurjchem-2455	142	14	attack	attack	VERB
eurjchem-2455	142	15	β	β	X
eurjchem-2455	142	16	valine	valine	NOUN
eurjchem-2455	142	17	(	(	PUNCT
eurjchem-2455	142	18	valbeta6	valbeta6	NOUN
eurjchem-2455	142	19	)	)	PUNCT
eurjchem-2455	142	20	of	of	ADP
eurjchem-2455	142	21	proval	proval	NOUN
eurjchem-2455	142	22	-	-	PUNCT
eurjchem-2455	142	23	glu	glu	NOUN
eurjchem-2455	142	24	to	to	PART
eurjchem-2455	142	25	make	make	VERB
eurjchem-2455	142	26	the	the	DET
eurjchem-2455	142	27	behavior	behavior	NOUN
eurjchem-2455	142	28	of	of	ADP
eurjchem-2455	142	29	hbs	hbs	PROPN
eurjchem-2455	142	30	like	like	ADP
eurjchem-2455	142	31	hba	hba	PROPN
eurjchem-2455	142	32	.	.	PUNCT
eurjchem-2455	143	1	iv	iv	X
eurjchem-2455	143	2	.	.	PUNCT
eurjchem-2455	144	1	all	all	DET
eurjchem-2455	144	2	antisickling	antisickle	VERB
eurjchem-2455	144	3	agents	agent	NOUN
eurjchem-2455	144	4	are	be	AUX
eurjchem-2455	144	5	aromatic	aromatic	ADJ
eurjchem-2455	144	6	aldehydes	aldehyde	NOUN
eurjchem-2455	144	7	[	[	PUNCT
eurjchem-2455	144	8	13	13	NUM
eurjchem-2455	144	9	-	-	SYM
eurjchem-2455	144	10	19	19	NUM
eurjchem-2455	144	11	]	]	PUNCT
eurjchem-2455	144	12	that	that	PRON
eurjchem-2455	144	13	react	react	VERB
eurjchem-2455	144	14	with	with	ADP
eurjchem-2455	144	15	hb	hb	NOUN
eurjchem-2455	144	16	αval1	αval1	ADJ
eurjchem-2455	144	17	amines	amine	NOUN
eurjchem-2455	144	18	to	to	PART
eurjchem-2455	144	19	form	form	VERB
eurjchem-2455	144	20	the	the	DET
eurjchem-2455	144	21	schiff	schiff	NOUN
eurjchem-2455	144	22	base	base	NOUN
eurjchem-2455	144	23	adduct	adduct	NOUN
eurjchem-2455	144	24	,	,	PUNCT
eurjchem-2455	144	25	but	but	CCONJ
eurjchem-2455	144	26	what	what	PRON
eurjchem-2455	144	27	about	about	ADP
eurjchem-2455	144	28	the	the	DET
eurjchem-2455	144	29	effect	effect	NOUN
eurjchem-2455	144	30	of	of	ADP
eurjchem-2455	144	31	ph	ph	NOUN
eurjchem-2455	144	32	on	on	ADP
eurjchem-2455	144	33	it	it	PRON
eurjchem-2455	144	34	?	?	PUNCT
eurjchem-2455	145	1	as	as	SCONJ
eurjchem-2455	145	2	schiff	schiff	NOUN
eurjchem-2455	145	3	base	base	NOUN
eurjchem-2455	145	4	adduct	adduct	NOUN
eurjchem-2455	145	5	formation	formation	NOUN
eurjchem-2455	145	6	is	be	AUX
eurjchem-2455	145	7	a	a	DET
eurjchem-2455	145	8	ph	ph	ADJ
eurjchem-2455	145	9	-	-	ADJ
eurjchem-2455	145	10	dependent	dependent	ADJ
eurjchem-2455	145	11	condensation	condensation	NOUN
eurjchem-2455	145	12	reaction	reaction	NOUN
eurjchem-2455	145	13	[	[	X
eurjchem-2455	145	14	52	52	NUM
eurjchem-2455	145	15	]	]	PUNCT
eurjchem-2455	145	16	that	that	PRON
eurjchem-2455	145	17	occurs	occur	VERB
eurjchem-2455	145	18	between	between	ADP
eurjchem-2455	145	19	carbonyl	carbonyl	NOUN
eurjchem-2455	145	20	compounds	compound	NOUN
eurjchem-2455	145	21	(	(	PUNCT
eurjchem-2455	145	22	aldehydes	aldehyde	NOUN
eurjchem-2455	145	23	/	/	SYM
eurjchem-2455	145	24	ketones	ketone	NOUN
eurjchem-2455	145	25	)	)	PUNCT
eurjchem-2455	145	26	and	and	CCONJ
eurjchem-2455	145	27	ammonia	ammonia	NOUN
eurjchem-2455	145	28	derivatives	derivative	NOUN
eurjchem-2455	145	29	(	(	PUNCT
eurjchem-2455	145	30	amine	amine	NOUN
eurjchem-2455	145	31	)	)	PUNCT
eurjchem-2455	145	32	,	,	PUNCT
eurjchem-2455	145	33	374	374	NUM
eurjchem-2455	145	34	suhail	suhail	NOUN
eurjchem-2455	145	35	et	et	PROPN
eurjchem-2455	145	36	al	al	PROPN
eurjchem-2455	145	37	.	.	PUNCT
eurjchem-2455	145	38	/	/	SYM
eurjchem-2455	145	39	european	european	PROPN
eurjchem-2455	145	40	journal	journal	PROPN
eurjchem-2455	145	41	of	of	ADP
eurjchem-2455	145	42	chemistry	chemistry	NOUN
eurjchem-2455	145	43	14	14	NUM
eurjchem-2455	145	44	(	(	PUNCT
eurjchem-2455	145	45	3	3	NUM
eurjchem-2455	145	46	)	)	PUNCT
eurjchem-2455	145	47	(	(	PUNCT
eurjchem-2455	145	48	2023	2023	NUM
eurjchem-2455	145	49	)	)	PUNCT
eurjchem-2455	145	50	370	370	NUM
eurjchem-2455	145	51	-	-	SYM
eurjchem-2455	145	52	375	375	NUM
eurjchem-2455	145	53	2023	2023	NUM
eurjchem-2455	145	54	–	–	PUNCT
eurjchem-2455	145	55	european	european	ADJ
eurjchem-2455	145	56	journal	journal	NOUN
eurjchem-2455	145	57	of	of	ADP
eurjchem-2455	145	58	chemistry	chemistry	NOUN
eurjchem-2455	145	59	–	–	PUNCT
eurjchem-2455	145	60	cc	cc	NOUN
eurjchem-2455	145	61	by	by	ADP
eurjchem-2455	145	62	nc	nc	PROPN
eurjchem-2455	145	63	–	–	PUNCT
eurjchem-2455	145	64	doi	doi	NOUN
eurjchem-2455	145	65	:	:	PUNCT
eurjchem-2455	145	66	10.5155	10.5155	NUM
eurjchem-2455	145	67	/	/	SYM
eurjchem-2455	145	68	eurjchem.14.3.370	eurjchem.14.3.370	NOUN
eurjchem-2455	145	69	-	-	SYM
eurjchem-2455	145	70	375.2455	375.2455	NUM
eurjchem-2455	145	71	no	no	DET
eurjchem-2455	145	72	ph	ph	ADJ
eurjchem-2455	145	73	effect	effect	NOUN
eurjchem-2455	145	74	was	be	AUX
eurjchem-2455	145	75	studied	study	VERB
eurjchem-2455	145	76	in	in	ADP
eurjchem-2455	145	77	the	the	DET
eurjchem-2455	145	78	formation	formation	NOUN
eurjchem-2455	145	79	of	of	ADP
eurjchem-2455	145	80	schiff	schiff	NOUN
eurjchem-2455	145	81	base	base	NOUN
eurjchem-2455	145	82	adducts	adduct	VERB
eurjchem-2455	145	83	.	.	PUNCT
eurjchem-2455	146	1	in	in	ADP
eurjchem-2455	146	2	the	the	DET
eurjchem-2455	146	3	future	future	NOUN
eurjchem-2455	146	4	,	,	PUNCT
eurjchem-2455	146	5	if	if	SCONJ
eurjchem-2455	146	6	it	it	PRON
eurjchem-2455	146	7	is	be	AUX
eurjchem-2455	146	8	done	do	VERB
eurjchem-2455	146	9	,	,	PUNCT
eurjchem-2455	146	10	it	it	PRON
eurjchem-2455	146	11	will	will	AUX
eurjchem-2455	146	12	be	be	AUX
eurjchem-2455	146	13	very	very	ADV
eurjchem-2455	146	14	helpful	helpful	ADJ
eurjchem-2455	146	15	in	in	ADP
eurjchem-2455	146	16	increasing	increase	VERB
eurjchem-2455	146	17	the	the	DET
eurjchem-2455	146	18	potency	potency	NOUN
eurjchem-2455	146	19	of	of	ADP
eurjchem-2455	146	20	the	the	DET
eurjchem-2455	146	21	available	available	ADJ
eurjchem-2455	146	22	antisickling	antisickle	VERB
eurjchem-2455	146	23	agent	agent	NOUN
eurjchem-2455	146	24	.	.	PUNCT
eurjchem-2455	147	1	v.	v.	ADP
eurjchem-2455	147	2	of	of	ADP
eurjchem-2455	147	3	course	course	NOUN
eurjchem-2455	147	4	,	,	PUNCT
eurjchem-2455	147	5	benzenoid	benzenoid	NOUN
eurjchem-2455	147	6	aromatic	aromatic	ADJ
eurjchem-2455	147	7	aldehydes	aldehyde	NOUN
eurjchem-2455	147	8	and	and	CCONJ
eurjchem-2455	147	9	their	their	PRON
eurjchem-2455	147	10	derivatives	derivative	NOUN
eurjchem-2455	147	11	[	[	PUNCT
eurjchem-2455	147	12	13	13	NUM
eurjchem-2455	147	13	-	-	SYM
eurjchem-2455	147	14	18	18	NUM
eurjchem-2455	147	15	]	]	PUNCT
eurjchem-2455	147	16	are	be	AUX
eurjchem-2455	147	17	found	find	VERB
eurjchem-2455	147	18	promising	promise	VERB
eurjchem-2455	147	19	drugs	drug	NOUN
eurjchem-2455	147	20	in	in	ADP
eurjchem-2455	147	21	the	the	DET
eurjchem-2455	147	22	treatment	treatment	NOUN
eurjchem-2455	147	23	of	of	ADP
eurjchem-2455	147	24	sickle	sickle	NOUN
eurjchem-2455	147	25	cell	cell	NOUN
eurjchem-2455	147	26	anemia	anemia	NOUN
eurjchem-2455	147	27	,	,	PUNCT
eurjchem-2455	147	28	but	but	CCONJ
eurjchem-2455	147	29	what	what	PRON
eurjchem-2455	147	30	about	about	ADP
eurjchem-2455	147	31	nonbenzenoid	nonbenzenoid	ADJ
eurjchem-2455	147	32	aromatic	aromatic	ADJ
eurjchem-2455	147	33	aldehydes	aldehyde	NOUN
eurjchem-2455	147	34	e.g.	e.g.	ADV
eurjchem-2455	147	35	5	5	NUM
eurjchem-2455	147	36	-	-	PUNCT
eurjchem-2455	147	37	hmf	hmf	NOUN
eurjchem-2455	148	1	[	[	X
eurjchem-2455	148	2	19	19	NUM
eurjchem-2455	148	3	]	]	PUNCT
eurjchem-2455	148	4	?	?	PUNCT
eurjchem-2455	149	1	therefore	therefore	ADV
eurjchem-2455	149	2	,	,	PUNCT
eurjchem-2455	149	3	non	non	NOUN
eurjchem-2455	149	4	-	-	NOUN
eurjchem-2455	149	5	benzenoids	benzenoid	NOUN
eurjchem-2455	149	6	,	,	PUNCT
eurjchem-2455	149	7	aromatic	aromatic	ADJ
eurjchem-2455	149	8	aldehydes	aldehyde	NOUN
eurjchem-2455	149	9	,	,	PUNCT
eurjchem-2455	149	10	and	and	CCONJ
eurjchem-2455	149	11	their	their	PRON
eurjchem-2455	149	12	derivatives	derivative	NOUN
eurjchem-2455	149	13	should	should	AUX
eurjchem-2455	149	14	also	also	ADV
eurjchem-2455	149	15	be	be	AUX
eurjchem-2455	149	16	taken	take	VERB
eurjchem-2455	149	17	under	under	ADP
eurjchem-2455	149	18	trial	trial	NOUN
eurjchem-2455	149	19	.	.	PUNCT
eurjchem-2455	150	1	it	it	PRON
eurjchem-2455	150	2	will	will	AUX
eurjchem-2455	150	3	also	also	ADV
eurjchem-2455	150	4	be	be	AUX
eurjchem-2455	150	5	very	very	ADV
eurjchem-2455	150	6	helpful	helpful	ADJ
eurjchem-2455	150	7	in	in	ADP
eurjchem-2455	150	8	the	the	DET
eurjchem-2455	150	9	development	development	NOUN
eurjchem-2455	150	10	of	of	ADP
eurjchem-2455	150	11	a	a	DET
eurjchem-2455	150	12	more	more	ADV
eurjchem-2455	150	13	potent	potent	ADJ
eurjchem-2455	150	14	antisickling	antisickle	VERB
eurjchem-2455	150	15	agent	agent	NOUN
eurjchem-2455	150	16	.	.	PUNCT
eurjchem-2455	151	1	5	5	X
eurjchem-2455	151	2	.	.	PUNCT
eurjchem-2455	151	3	the	the	DET
eurjchem-2455	151	4	tactic	tactic	NOUN
eurjchem-2455	151	5	for	for	ADP
eurjchem-2455	151	6	the	the	DET
eurjchem-2455	151	7	selection	selection	NOUN
eurjchem-2455	151	8	of	of	ADP
eurjchem-2455	151	9	a	a	DET
eurjchem-2455	151	10	more	more	ADV
eurjchem-2455	151	11	potent	potent	ADJ
eurjchem-2455	151	12	antisickling	antisickle	VERB
eurjchem-2455	151	13	drug	drug	NOUN
eurjchem-2455	151	14	before	before	ADP
eurjchem-2455	151	15	synthesis	synthesis	NOUN
eurjchem-2455	151	16	for	for	ADP
eurjchem-2455	151	17	the	the	DET
eurjchem-2455	151	18	selection	selection	NOUN
eurjchem-2455	151	19	of	of	ADP
eurjchem-2455	151	20	the	the	DET
eurjchem-2455	151	21	anti	anti	ADJ
eurjchem-2455	151	22	-	-	ADJ
eurjchem-2455	151	23	sickling	sickling	ADJ
eurjchem-2455	151	24	drug	drug	NOUN
eurjchem-2455	151	25	before	before	ADP
eurjchem-2455	151	26	its	its	PRON
eurjchem-2455	151	27	synthesis	synthesis	NOUN
eurjchem-2455	151	28	,	,	PUNCT
eurjchem-2455	151	29	first	first	ADV
eurjchem-2455	151	30	,	,	PUNCT
eurjchem-2455	151	31	the	the	DET
eurjchem-2455	151	32	binding	bind	VERB
eurjchem-2455	151	33	affinity	affinity	NOUN
eurjchem-2455	151	34	or	or	CCONJ
eurjchem-2455	151	35	docking	docking	NOUN
eurjchem-2455	151	36	study	study	NOUN
eurjchem-2455	151	37	of	of	ADP
eurjchem-2455	151	38	different	different	ADJ
eurjchem-2455	151	39	compounds	compound	NOUN
eurjchem-2455	151	40	with	with	ADP
eurjchem-2455	151	41	the	the	DET
eurjchem-2455	151	42	β	β	NOUN
eurjchem-2455	151	43	-	-	PUNCT
eurjchem-2455	151	44	valine	valine	NOUN
eurjchem-2455	151	45	residue	residue	NOUN
eurjchem-2455	151	46	of	of	ADP
eurjchem-2455	151	47	pro	pro	ADJ
eurjchem-2455	151	48	-	-	ADJ
eurjchem-2455	151	49	val	val	ADJ
eurjchem-2455	151	50	-	-	PUNCT
eurjchem-2455	151	51	glu	glu	NOUN
eurjchem-2455	151	52	must	must	AUX
eurjchem-2455	151	53	be	be	AUX
eurjchem-2455	151	54	done	do	VERB
eurjchem-2455	151	55	computationally	computationally	ADV
eurjchem-2455	151	56	.	.	PUNCT
eurjchem-2455	152	1	among	among	ADP
eurjchem-2455	152	2	the	the	DET
eurjchem-2455	152	3	studied	study	VERB
eurjchem-2455	152	4	compounds	compound	NOUN
eurjchem-2455	152	5	,	,	PUNCT
eurjchem-2455	152	6	only	only	ADV
eurjchem-2455	152	7	that	that	SCONJ
eurjchem-2455	152	8	compound	compound	NOUN
eurjchem-2455	152	9	must	must	AUX
eurjchem-2455	152	10	be	be	AUX
eurjchem-2455	152	11	selected	select	VERB
eurjchem-2455	152	12	which	which	PRON
eurjchem-2455	152	13	will	will	AUX
eurjchem-2455	152	14	show	show	VERB
eurjchem-2455	152	15	the	the	DET
eurjchem-2455	152	16	highest	high	ADJ
eurjchem-2455	152	17	binding	bind	VERB
eurjchem-2455	152	18	affinity	affinity	NOUN
eurjchem-2455	152	19	with	with	ADP
eurjchem-2455	152	20	the	the	DET
eurjchem-2455	152	21	β	β	NOUN
eurjchem-2455	152	22	-	-	PUNCT
eurjchem-2455	152	23	valine	valine	NOUN
eurjchem-2455	152	24	residue	residue	NOUN
eurjchem-2455	152	25	of	of	ADP
eurjchem-2455	152	26	pro	pro	ADJ
eurjchem-2455	152	27	-	-	ADJ
eurjchem-2455	152	28	val	val	ADJ
eurjchem-2455	152	29	-	-	PUNCT
eurjchem-2455	152	30	glu	glu	NOUN
eurjchem-2455	152	31	.	.	PUNCT
eurjchem-2455	153	1	after	after	ADP
eurjchem-2455	153	2	this	this	PRON
eurjchem-2455	153	3	,	,	PUNCT
eurjchem-2455	153	4	the	the	DET
eurjchem-2455	153	5	binding	bind	VERB
eurjchem-2455	153	6	affinity	affinity	NOUN
eurjchem-2455	153	7	study	study	NOUN
eurjchem-2455	153	8	of	of	ADP
eurjchem-2455	153	9	the	the	DET
eurjchem-2455	153	10	selected	select	VERB
eurjchem-2455	153	11	compound	compound	NOUN
eurjchem-2455	153	12	with	with	ADP
eurjchem-2455	153	13	βvaline	βvaline	NOUN
eurjchem-2455	153	14	residue	residue	NOUN
eurjchem-2455	153	15	should	should	AUX
eurjchem-2455	153	16	be	be	AUX
eurjchem-2455	153	17	done	do	VERB
eurjchem-2455	153	18	in	in	ADP
eurjchem-2455	153	19	a	a	DET
eurjchem-2455	153	20	polypeptide	polypeptide	ADJ
eurjchem-2455	153	21	chain	chain	NOUN
eurjchem-2455	153	22	of	of	ADP
eurjchem-2455	153	23	hbs	hbs	PROPN
eurjchem-2455	153	24	.	.	PUNCT
eurjchem-2455	154	1	if	if	SCONJ
eurjchem-2455	154	2	the	the	DET
eurjchem-2455	154	3	drug	drug	NOUN
eurjchem-2455	154	4	shows	show	VERB
eurjchem-2455	154	5	the	the	DET
eurjchem-2455	154	6	same	same	ADJ
eurjchem-2455	154	7	result	result	NOUN
eurjchem-2455	154	8	in	in	ADP
eurjchem-2455	154	9	a	a	DET
eurjchem-2455	154	10	polypeptide	polypeptide	ADJ
eurjchem-2455	154	11	chain	chain	NOUN
eurjchem-2455	154	12	,	,	PUNCT
eurjchem-2455	154	13	then	then	ADV
eurjchem-2455	154	14	we	we	PRON
eurjchem-2455	154	15	also	also	ADV
eurjchem-2455	154	16	have	have	VERB
eurjchem-2455	154	17	to	to	PART
eurjchem-2455	154	18	go	go	VERB
eurjchem-2455	154	19	for	for	ADP
eurjchem-2455	154	20	its	its	PRON
eurjchem-2455	154	21	synthesis	synthesis	NOUN
eurjchem-2455	154	22	and	and	CCONJ
eurjchem-2455	154	23	then	then	ADV
eurjchem-2455	154	24	for	for	ADP
eurjchem-2455	154	25	its	its	PRON
eurjchem-2455	154	26	derivatization	derivatization	NOUN
eurjchem-2455	154	27	to	to	PART
eurjchem-2455	154	28	increase	increase	VERB
eurjchem-2455	154	29	its	its	PRON
eurjchem-2455	154	30	potency	potency	NOUN
eurjchem-2455	154	31	.	.	PUNCT
eurjchem-2455	155	1	in	in	ADP
eurjchem-2455	155	2	the	the	DET
eurjchem-2455	155	3	future	future	NOUN
eurjchem-2455	155	4	,	,	PUNCT
eurjchem-2455	155	5	if	if	SCONJ
eurjchem-2455	155	6	the	the	DET
eurjchem-2455	155	7	drug	drug	NOUN
eurjchem-2455	155	8	attached	attach	VERB
eurjchem-2455	155	9	to	to	ADP
eurjchem-2455	155	10	β	β	PROPN
eurjchem-2455	155	11	valine	valine	NOUN
eurjchem-2455	155	12	(	(	PUNCT
eurjchem-2455	155	13	valbeta6	valbeta6	NOUN
eurjchem-2455	155	14	)	)	PUNCT
eurjchem-2455	155	15	of	of	ADP
eurjchem-2455	155	16	pro	pro	ADJ
eurjchem-2455	155	17	-	-	ADJ
eurjchem-2455	155	18	val	val	ADJ
eurjchem-2455	155	19	-	-	PUNCT
eurjchem-2455	155	20	glu	glu	NOUN
eurjchem-2455	155	21	is	be	AUX
eurjchem-2455	155	22	synthesized	synthesize	VERB
eurjchem-2455	155	23	,	,	PUNCT
eurjchem-2455	155	24	there	there	PRON
eurjchem-2455	155	25	would	would	AUX
eurjchem-2455	155	26	be	be	AUX
eurjchem-2455	155	27	two	two	NUM
eurjchem-2455	155	28	main	main	ADJ
eurjchem-2455	155	29	things	thing	NOUN
eurjchem-2455	155	30	associated	associate	VERB
eurjchem-2455	155	31	with	with	ADP
eurjchem-2455	155	32	its	its	PRON
eurjchem-2455	155	33	mechanism	mechanism	NOUN
eurjchem-2455	155	34	of	of	ADP
eurjchem-2455	155	35	action	action	NOUN
eurjchem-2455	155	36	which	which	PRON
eurjchem-2455	155	37	are	be	AUX
eurjchem-2455	155	38	as	as	SCONJ
eurjchem-2455	155	39	follows	follow	VERB
eurjchem-2455	155	40	:	:	PUNCT
eurjchem-2455	155	41	i.	i.	NOUN
eurjchem-2455	155	42	it	it	PRON
eurjchem-2455	155	43	will	will	AUX
eurjchem-2455	155	44	not	not	PART
eurjchem-2455	155	45	form	form	VERB
eurjchem-2455	155	46	schiff	schiff	NOUN
eurjchem-2455	155	47	base	base	NOUN
eurjchem-2455	155	48	adducts	adduct	NOUN
eurjchem-2455	155	49	with	with	ADP
eurjchem-2455	155	50	β	β	X
eurjchem-2455	155	51	valine	valine	X
eurjchem-2455	155	52	(	(	PUNCT
eurjchem-2455	155	53	valbeta6	valbeta6	NOUN
eurjchem-2455	155	54	)	)	PUNCT
eurjchem-2455	155	55	of	of	ADP
eurjchem-2455	155	56	pro	pro	ADJ
eurjchem-2455	155	57	-	-	ADJ
eurjchem-2455	155	58	val	val	ADJ
eurjchem-2455	155	59	-	-	PUNCT
eurjchem-2455	155	60	glu	glu	NOUN
eurjchem-2455	155	61	as	as	SCONJ
eurjchem-2455	155	62	other	other	ADJ
eurjchem-2455	155	63	available	available	ADJ
eurjchem-2455	155	64	antisickling	antisickle	VERB
eurjchem-2455	155	65	agents	agent	NOUN
eurjchem-2455	155	66	do	do	VERB
eurjchem-2455	155	67	.	.	PUNCT
eurjchem-2455	156	1	it	it	PRON
eurjchem-2455	156	2	is	be	AUX
eurjchem-2455	156	3	because	because	SCONJ
eurjchem-2455	156	4	β	β	X
eurjchem-2455	156	5	valine	valine	NOUN
eurjchem-2455	156	6	(	(	PUNCT
eurjchem-2455	156	7	valbeta6	valbeta6	NOUN
eurjchem-2455	156	8	)	)	PUNCT
eurjchem-2455	156	9	amine	amine	NOUN
eurjchem-2455	156	10	group	group	NOUN
eurjchem-2455	156	11	is	be	AUX
eurjchem-2455	156	12	used	use	VERB
eurjchem-2455	156	13	in	in	ADP
eurjchem-2455	156	14	the	the	DET
eurjchem-2455	156	15	formation	formation	NOUN
eurjchem-2455	156	16	of	of	ADP
eurjchem-2455	156	17	a	a	DET
eurjchem-2455	156	18	peptide	peptide	NOUN
eurjchem-2455	156	19	bond	bond	NOUN
eurjchem-2455	156	20	.	.	PUNCT
eurjchem-2455	157	1	hence	hence	ADV
eurjchem-2455	157	2	,	,	PUNCT
eurjchem-2455	157	3	there	there	PRON
eurjchem-2455	157	4	will	will	AUX
eurjchem-2455	157	5	be	be	AUX
eurjchem-2455	157	6	no	no	DET
eurjchem-2455	157	7	chance	chance	NOUN
eurjchem-2455	157	8	to	to	PART
eurjchem-2455	157	9	build	build	VERB
eurjchem-2455	157	10	a	a	DET
eurjchem-2455	157	11	schiff	schiff	NOUN
eurjchem-2455	157	12	base	base	NOUN
eurjchem-2455	157	13	adduct	adduct	NOUN
eurjchem-2455	157	14	.	.	PUNCT
eurjchem-2455	158	1	therefore	therefore	ADV
eurjchem-2455	158	2	,	,	PUNCT
eurjchem-2455	158	3	the	the	DET
eurjchem-2455	158	4	mechanism	mechanism	NOUN
eurjchem-2455	158	5	of	of	ADP
eurjchem-2455	158	6	the	the	DET
eurjchem-2455	158	7	β	β	X
eurjchem-2455	158	8	valine	valine	NOUN
eurjchem-2455	158	9	(	(	PUNCT
eurjchem-2455	158	10	valbeta6	valbeta6	NOUN
eurjchem-2455	158	11	)	)	PUNCT
eurjchem-2455	158	12	attacking	attack	VERB
eurjchem-2455	158	13	the	the	DET
eurjchem-2455	158	14	drug	drug	NOUN
eurjchem-2455	158	15	would	would	AUX
eurjchem-2455	158	16	be	be	AUX
eurjchem-2455	158	17	different	different	ADJ
eurjchem-2455	158	18	from	from	ADP
eurjchem-2455	158	19	the	the	DET
eurjchem-2455	158	20	mechanism	mechanism	NOUN
eurjchem-2455	158	21	of	of	ADP
eurjchem-2455	158	22	action	action	NOUN
eurjchem-2455	158	23	of	of	ADP
eurjchem-2455	158	24	the	the	DET
eurjchem-2455	158	25	available	available	ADJ
eurjchem-2455	158	26	/	/	SYM
eurjchem-2455	158	27	known	know	VERB
eurjchem-2455	158	28	antisickling	antisickle	VERB
eurjchem-2455	158	29	drug	drug	NOUN
eurjchem-2455	158	30	.	.	PUNCT
eurjchem-2455	159	1	ii	ii	PROPN
eurjchem-2455	159	2	.	.	PUNCT
eurjchem-2455	160	1	it	it	PRON
eurjchem-2455	160	2	will	will	AUX
eurjchem-2455	160	3	increase	increase	VERB
eurjchem-2455	160	4	the	the	DET
eurjchem-2455	160	5	egap	egap	NOUN
eurjchem-2455	160	6	of	of	ADP
eurjchem-2455	160	7	pro	pro	ADJ
eurjchem-2455	160	8	-	-	ADJ
eurjchem-2455	160	9	val	val	ADJ
eurjchem-2455	160	10	-	-	PUNCT
eurjchem-2455	160	11	glu	glu	NOUN
eurjchem-2455	160	12	of	of	ADP
eurjchem-2455	160	13	hbs	hbs	PROPN
eurjchem-2455	160	14	to	to	PART
eurjchem-2455	160	15	make	make	VERB
eurjchem-2455	160	16	it	it	PRON
eurjchem-2455	160	17	less	less	ADJ
eurjchem-2455	160	18	or	or	CCONJ
eurjchem-2455	160	19	equally	equally	ADV
eurjchem-2455	160	20	reactive	reactive	ADJ
eurjchem-2455	160	21	to	to	ADP
eurjchem-2455	160	22	hba	hba	NOUN
eurjchem-2455	160	23	,	,	PUNCT
eurjchem-2455	160	24	so	so	SCONJ
eurjchem-2455	160	25	that	that	SCONJ
eurjchem-2455	160	26	hbs	hbs	PROPN
eurjchem-2455	160	27	could	could	AUX
eurjchem-2455	160	28	behave	behave	VERB
eurjchem-2455	160	29	as	as	ADP
eurjchem-2455	160	30	hba	hba	NOUN
eurjchem-2455	160	31	.	.	PUNCT
eurjchem-2455	161	1	for	for	ADP
eurjchem-2455	161	2	this	this	DET
eurjchem-2455	161	3	purpose	purpose	NOUN
eurjchem-2455	161	4	,	,	PUNCT
eurjchem-2455	161	5	the	the	DET
eurjchem-2455	161	6	drug	drug	NOUN
eurjchem-2455	161	7	having	have	VERB
eurjchem-2455	161	8	a	a	DET
eurjchem-2455	161	9	greater	great	ADJ
eurjchem-2455	161	10	affinity	affinity	NOUN
eurjchem-2455	161	11	for	for	ADP
eurjchem-2455	161	12	β	β	X
eurjchem-2455	161	13	valine	valine	NOUN
eurjchem-2455	161	14	(	(	PUNCT
eurjchem-2455	161	15	valbeta6	valbeta6	NOUN
eurjchem-2455	161	16	)	)	PUNCT
eurjchem-2455	161	17	in	in	ADP
eurjchem-2455	161	18	a	a	DET
eurjchem-2455	161	19	polypeptide	polypeptide	ADJ
eurjchem-2455	161	20	chain	chain	NOUN
eurjchem-2455	161	21	would	would	AUX
eurjchem-2455	161	22	first	first	ADV
eurjchem-2455	161	23	be	be	AUX
eurjchem-2455	161	24	synthesized	synthesize	VERB
eurjchem-2455	161	25	as	as	SCONJ
eurjchem-2455	161	26	described	describe	VERB
eurjchem-2455	161	27	above	above	ADV
eurjchem-2455	161	28	.	.	PUNCT
eurjchem-2455	162	1	before	before	ADP
eurjchem-2455	162	2	its	its	PRON
eurjchem-2455	162	3	derivatization	derivatization	NOUN
eurjchem-2455	162	4	,	,	PUNCT
eurjchem-2455	162	5	the	the	DET
eurjchem-2455	162	6	binding	bind	VERB
eurjchem-2455	162	7	site	site	NOUN
eurjchem-2455	162	8	variation	variation	NOUN
eurjchem-2455	162	9	of	of	ADP
eurjchem-2455	162	10	β	β	X
eurjchem-2455	162	11	valine	valine	X
eurjchem-2455	162	12	(	(	PUNCT
eurjchem-2455	162	13	valbeta6	valbeta6	NOUN
eurjchem-2455	162	14	)	)	PUNCT
eurjchem-2455	162	15	with	with	ADP
eurjchem-2455	162	16	respect	respect	NOUN
eurjchem-2455	162	17	to	to	ADP
eurjchem-2455	162	18	the	the	DET
eurjchem-2455	162	19	introduction	introduction	NOUN
eurjchem-2455	162	20	of	of	ADP
eurjchem-2455	162	21	different	different	ADJ
eurjchem-2455	162	22	groups	group	NOUN
eurjchem-2455	162	23	in	in	ADP
eurjchem-2455	162	24	the	the	DET
eurjchem-2455	162	25	synthesized	synthesize	VERB
eurjchem-2455	162	26	drug	drug	NOUN
eurjchem-2455	162	27	would	would	AUX
eurjchem-2455	162	28	be	be	AUX
eurjchem-2455	162	29	computationally	computationally	ADV
eurjchem-2455	162	30	studied	study	VERB
eurjchem-2455	162	31	.	.	PUNCT
eurjchem-2455	163	1	only	only	ADV
eurjchem-2455	163	2	those	those	DET
eurjchem-2455	163	3	binding	bind	VERB
eurjchem-2455	163	4	sites	site	NOUN
eurjchem-2455	163	5	of	of	ADP
eurjchem-2455	163	6	β	β	X
eurjchem-2455	163	7	valine	valine	NOUN
eurjchem-2455	163	8	(	(	PUNCT
eurjchem-2455	163	9	valbeta6	valbeta6	NOUN
eurjchem-2455	163	10	)	)	PUNCT
eurjchem-2455	163	11	would	would	AUX
eurjchem-2455	163	12	be	be	AUX
eurjchem-2455	163	13	considered	consider	VERB
eurjchem-2455	163	14	better	well	ADV
eurjchem-2455	163	15	where	where	SCONJ
eurjchem-2455	163	16	the	the	DET
eurjchem-2455	163	17	attachment	attachment	NOUN
eurjchem-2455	163	18	of	of	ADP
eurjchem-2455	163	19	the	the	DET
eurjchem-2455	163	20	synthesized	synthesize	VERB
eurjchem-2455	163	21	drug	drug	NOUN
eurjchem-2455	163	22	would	would	AUX
eurjchem-2455	163	23	cause	cause	VERB
eurjchem-2455	163	24	an	an	DET
eurjchem-2455	163	25	increase	increase	NOUN
eurjchem-2455	163	26	in	in	ADP
eurjchem-2455	163	27	the	the	DET
eurjchem-2455	163	28	egap	egap	NOUN
eurjchem-2455	163	29	of	of	ADP
eurjchem-2455	163	30	pro	pro	ADJ
eurjchem-2455	163	31	-	-	ADJ
eurjchem-2455	163	32	val	val	ADJ
eurjchem-2455	163	33	-	-	PUNCT
eurjchem-2455	163	34	glu	glu	NOUN
eurjchem-2455	163	35	of	of	ADP
eurjchem-2455	163	36	hbs	hbs	PROPN
eurjchem-2455	163	37	.	.	PROPN
eurjchem-2455	164	1	6	6	NUM
eurjchem-2455	164	2	.	.	X
eurjchem-2455	164	3	conclusion	conclusion	NOUN
eurjchem-2455	164	4	the	the	DET
eurjchem-2455	164	5	above	above	ADJ
eurjchem-2455	164	6	sections	section	NOUN
eurjchem-2455	164	7	have	have	AUX
eurjchem-2455	164	8	left	leave	VERB
eurjchem-2455	164	9	a	a	DET
eurjchem-2455	164	10	large	large	ADJ
eurjchem-2455	164	11	amount	amount	NOUN
eurjchem-2455	164	12	of	of	ADP
eurjchem-2455	164	13	work	work	NOUN
eurjchem-2455	164	14	for	for	ADP
eurjchem-2455	164	15	scientists	scientist	NOUN
eurjchem-2455	164	16	working	work	VERB
eurjchem-2455	164	17	in	in	ADP
eurjchem-2455	164	18	the	the	DET
eurjchem-2455	164	19	fields	field	NOUN
eurjchem-2455	164	20	of	of	ADP
eurjchem-2455	164	21	computational	computational	ADJ
eurjchem-2455	164	22	chemistry	chemistry	NOUN
eurjchem-2455	164	23	,	,	PUNCT
eurjchem-2455	164	24	molecular	molecular	ADJ
eurjchem-2455	164	25	biology	biology	NOUN
eurjchem-2455	164	26	,	,	PUNCT
eurjchem-2455	164	27	and	and	CCONJ
eurjchem-2455	164	28	medicinal	medicinal	ADJ
eurjchem-2455	164	29	chemistry	chemistry	NOUN
eurjchem-2455	164	30	.	.	PUNCT
eurjchem-2455	165	1	the	the	DET
eurjchem-2455	165	2	presented	present	VERB
eurjchem-2455	165	3	paper	paper	NOUN
eurjchem-2455	165	4	also	also	ADV
eurjchem-2455	165	5	describes	describe	VERB
eurjchem-2455	165	6	how	how	SCONJ
eurjchem-2455	165	7	antisickling	antisickle	VERB
eurjchem-2455	165	8	drug	drug	NOUN
eurjchem-2455	165	9	development	development	NOUN
eurjchem-2455	165	10	can	can	AUX
eurjchem-2455	165	11	be	be	AUX
eurjchem-2455	165	12	improved	improve	VERB
eurjchem-2455	165	13	.	.	PUNCT
eurjchem-2455	166	1	of	of	ADP
eurjchem-2455	166	2	course	course	NOUN
eurjchem-2455	166	3	,	,	PUNCT
eurjchem-2455	166	4	many	many	ADJ
eurjchem-2455	166	5	computationally	computationally	ADV
eurjchem-2455	166	6	evaluated	evaluate	VERB
eurjchem-2455	166	7	antisickling	antisickle	VERB
eurjchem-2455	166	8	drugs	drug	NOUN
eurjchem-2455	166	9	were	be	AUX
eurjchem-2455	166	10	found	find	VERB
eurjchem-2455	166	11	during	during	ADP
eurjchem-2455	166	12	the	the	DET
eurjchem-2455	166	13	literature	literature	NOUN
eurjchem-2455	166	14	survey	survey	NOUN
eurjchem-2455	166	15	,	,	PUNCT
eurjchem-2455	166	16	but	but	CCONJ
eurjchem-2455	166	17	the	the	DET
eurjchem-2455	166	18	gaps	gap	NOUN
eurjchem-2455	166	19	found	find	VERB
eurjchem-2455	166	20	in	in	ADP
eurjchem-2455	166	21	the	the	DET
eurjchem-2455	166	22	development	development	NOUN
eurjchem-2455	166	23	of	of	ADP
eurjchem-2455	166	24	such	such	ADJ
eurjchem-2455	166	25	drugs	drug	NOUN
eurjchem-2455	166	26	can	can	AUX
eurjchem-2455	166	27	not	not	PART
eurjchem-2455	166	28	be	be	AUX
eurjchem-2455	166	29	ignored	ignore	VERB
eurjchem-2455	166	30	.	.	PUNCT
eurjchem-2455	167	1	keeping	keep	VERB
eurjchem-2455	167	2	gaps	gap	NOUN
eurjchem-2455	167	3	in	in	ADP
eurjchem-2455	167	4	the	the	DET
eurjchem-2455	167	5	development	development	NOUN
eurjchem-2455	167	6	of	of	ADP
eurjchem-2455	167	7	antisickling	antisickle	VERB
eurjchem-2455	167	8	drugs	drug	NOUN
eurjchem-2455	167	9	into	into	ADP
eurjchem-2455	167	10	consideration	consideration	NOUN
eurjchem-2455	167	11	,	,	PUNCT
eurjchem-2455	167	12	not	not	PART
eurjchem-2455	167	13	only	only	ADV
eurjchem-2455	167	14	the	the	DET
eurjchem-2455	167	15	potency	potency	NOUN
eurjchem-2455	167	16	of	of	ADP
eurjchem-2455	167	17	anti	anti	ADJ
eurjchem-2455	167	18	-	-	ADJ
eurjchem-2455	167	19	sickling	sickling	ADJ
eurjchem-2455	167	20	agents	agent	NOUN
eurjchem-2455	167	21	can	can	AUX
eurjchem-2455	167	22	be	be	AUX
eurjchem-2455	167	23	increased	increase	VERB
eurjchem-2455	167	24	but	but	CCONJ
eurjchem-2455	167	25	also	also	ADV
eurjchem-2455	167	26	new	new	ADJ
eurjchem-2455	167	27	/	/	SYM
eurjchem-2455	167	28	different	different	ADJ
eurjchem-2455	167	29	drugs	drug	NOUN
eurjchem-2455	167	30	with	with	ADP
eurjchem-2455	167	31	more	more	ADJ
eurjchem-2455	167	32	potency	potency	NOUN
eurjchem-2455	167	33	can	can	AUX
eurjchem-2455	167	34	be	be	AUX
eurjchem-2455	167	35	synthesized	synthesize	VERB
eurjchem-2455	167	36	.	.	PUNCT
eurjchem-2455	168	1	supporting	support	VERB
eurjchem-2455	168	2	information	information	NOUN
eurjchem-2455	168	3	the	the	DET
eurjchem-2455	168	4	supporting	support	VERB
eurjchem-2455	168	5	data	datum	NOUN
eurjchem-2455	168	6	of	of	ADP
eurjchem-2455	168	7	the	the	DET
eurjchem-2455	168	8	presented	present	VERB
eurjchem-2455	168	9	work	work	NOUN
eurjchem-2455	168	10	are	be	AUX
eurjchem-2455	168	11	publicly	publicly	ADV
eurjchem-2455	168	12	available	available	ADJ
eurjchem-2455	168	13	on	on	ADP
eurjchem-2455	168	14	mohd	mohd	PROPN
eurjchem-2455	168	15	suhail	suhail	PROPN
eurjchem-2455	168	16	.	.	PUNCT
eurjchem-2455	169	1	(	(	PUNCT
eurjchem-2455	169	2	2023	2023	NUM
eurjchem-2455	169	3	)	)	PUNCT
eurjchem-2455	169	4	.	.	PUNCT
eurjchem-2455	170	1	output	output	NOUN
eurjchem-2455	170	2	files	file	NOUN
eurjchem-2455	170	3	of	of	ADP
eurjchem-2455	170	4	the	the	DET
eurjchem-2455	170	5	theoretical	theoretical	ADJ
eurjchem-2455	170	6	calculations	calculation	NOUN
eurjchem-2455	170	7	done	do	VERB
eurjchem-2455	170	8	for	for	ADP
eurjchem-2455	170	9	pro	pro	ADJ
eurjchem-2455	170	10	-	-	ADJ
eurjchem-2455	170	11	gluglu	gluglu	ADJ
eurjchem-2455	170	12	and	and	CCONJ
eurjchem-2455	170	13	pro	pro	ADJ
eurjchem-2455	170	14	-	-	ADJ
eurjchem-2455	170	15	val	val	ADJ
eurjchem-2455	170	16	-	-	PUNCT
eurjchem-2455	170	17	glu	glu	NOUN
eurjchem-2455	170	18	(	(	PUNCT
eurjchem-2455	170	19	gaussian(r	gaussian(r	NOUN
eurjchem-2455	170	20	)	)	PUNCT
eurjchem-2455	170	21	03	03	NUM
eurjchem-2455	170	22	program	program	NOUN
eurjchem-2455	170	23	and	and	CCONJ
eurjchem-2455	170	24	gaussview	gaussview	NOUN
eurjchem-2455	170	25	6.0	6.0	NUM
eurjchem-2455	170	26	)	)	PUNCT
eurjchem-2455	171	1	[	[	X
eurjchem-2455	171	2	data	datum	NOUN
eurjchem-2455	171	3	set	set	VERB
eurjchem-2455	171	4	]	]	PUNCT
eurjchem-2455	171	5	.	.	PUNCT
eurjchem-2455	172	1	zenodo	zenodo	NOUN
eurjchem-2455	172	2	.	.	PUNCT
eurjchem-2455	173	1	https://doi.org/10.5281/zenodo.7729828	https://doi.org/10.5281/zenodo.7729828	X
eurjchem-2455	173	2	.	.	PUNCT
eurjchem-2455	174	1	acknowledgements	acknowledgement	NOUN
eurjchem-2455	174	2	i	i	PRON
eurjchem-2455	174	3	am	be	AUX
eurjchem-2455	174	4	very	very	ADV
eurjchem-2455	174	5	grateful	grateful	ADJ
eurjchem-2455	174	6	to	to	ADP
eurjchem-2455	174	7	siddhartha	siddhartha	PROPN
eurjchem-2455	174	8	(	(	PUNCT
eurjchem-2455	174	9	pg	pg	NOUN
eurjchem-2455	174	10	)	)	PUNCT
eurjchem-2455	174	11	college	college	NOUN
eurjchem-2455	174	12	for	for	ADP
eurjchem-2455	174	13	providing	provide	VERB
eurjchem-2455	174	14	me	i	PRON
eurjchem-2455	174	15	an	an	DET
eurjchem-2455	174	16	additional	additional	ADJ
eurjchem-2455	174	17	time	time	NOUN
eurjchem-2455	174	18	to	to	PART
eurjchem-2455	174	19	do	do	VERB
eurjchem-2455	174	20	this	this	DET
eurjchem-2455	174	21	computational	computational	ADJ
eurjchem-2455	174	22	study	study	NOUN
eurjchem-2455	174	23	.	.	PUNCT
eurjchem-2455	175	1	disclosure	disclosure	NOUN
eurjchem-2455	175	2	statement	statement	NOUN
eurjchem-2455	175	3	conflict	conflict	NOUN
eurjchem-2455	175	4	of	of	ADP
eurjchem-2455	175	5	interest	interest	NOUN
eurjchem-2455	175	6	:	:	PUNCT
eurjchem-2455	175	7	the	the	DET
eurjchem-2455	175	8	authors	author	NOUN
eurjchem-2455	175	9	declare	declare	VERB
eurjchem-2455	175	10	that	that	SCONJ
eurjchem-2455	175	11	they	they	PRON
eurjchem-2455	175	12	have	have	VERB
eurjchem-2455	175	13	no	no	DET
eurjchem-2455	175	14	conflict	conflict	NOUN
eurjchem-2455	175	15	of	of	ADP
eurjchem-2455	175	16	interest	interest	NOUN
eurjchem-2455	175	17	.	.	PUNCT
eurjchem-2455	176	1	ethical	ethical	ADJ
eurjchem-2455	176	2	approval	approval	NOUN
eurjchem-2455	176	3	:	:	PUNCT
eurjchem-2455	177	1	all	all	DET
eurjchem-2455	177	2	ethical	ethical	ADJ
eurjchem-2455	177	3	guidelines	guideline	NOUN
eurjchem-2455	177	4	have	have	AUX
eurjchem-2455	177	5	been	be	AUX
eurjchem-2455	177	6	adhered	adhere	VERB
eurjchem-2455	177	7	to	to	ADP
eurjchem-2455	177	8	.	.	PUNCT
eurjchem-2455	178	1	credit	credit	NOUN
eurjchem-2455	178	2	authorship	authorship	NOUN
eurjchem-2455	178	3	contribution	contribution	NOUN
eurjchem-2455	178	4	statement	statement	NOUN
eurjchem-2455	178	5	conceptualization	conceptualization	NOUN
eurjchem-2455	178	6	:	:	PUNCT
eurjchem-2455	178	7	mohammad	mohammad	PROPN
eurjchem-2455	178	8	suhail	suhail	PROPN
eurjchem-2455	178	9	;	;	PUNCT
eurjchem-2455	178	10	methodology	methodology	NOUN
eurjchem-2455	178	11	:	:	PUNCT
eurjchem-2455	178	12	safwana	safwana	PROPN
eurjchem-2455	178	13	usmani	usmani	PROPN
eurjchem-2455	178	14	;	;	PUNCT
eurjchem-2455	178	15	software	software	NOUN
eurjchem-2455	178	16	:	:	PUNCT
eurjchem-2455	178	17	mohammad	mohammad	PROPN
eurjchem-2455	178	18	suhail	suhail	PROPN
eurjchem-2455	178	19	;	;	PUNCT
eurjchem-2455	178	20	validation	validation	NOUN
eurjchem-2455	178	21	:	:	PUNCT
eurjchem-2455	178	22	mehmood	mehmood	PROPN
eurjchem-2455	178	23	ahmad	ahmad	PROPN
eurjchem-2455	178	24	;	;	PUNCT
eurjchem-2455	178	25	formal	formal	ADJ
eurjchem-2455	178	26	analysis	analysis	NOUN
eurjchem-2455	178	27	:	:	PUNCT
eurjchem-2455	178	28	safwana	safwana	PROPN
eurjchem-2455	178	29	usmani	usmani	PROPN
eurjchem-2455	178	30	;	;	PUNCT
eurjchem-2455	178	31	investigation	investigation	NOUN
eurjchem-2455	178	32	:	:	PUNCT
eurjchem-2455	178	33	mohammad	mohammad	PROPN
eurjchem-2455	178	34	suhail	suhail	PROPN
eurjchem-2455	178	35	;	;	PUNCT
eurjchem-2455	178	36	resources	resource	NOUN
eurjchem-2455	178	37	:	:	PUNCT
eurjchem-2455	178	38	mohammad	mohammad	PROPN
eurjchem-2455	178	39	suhail	suhail	PROPN
eurjchem-2455	178	40	;	;	PUNCT
eurjchem-2455	178	41	data	datum	NOUN
eurjchem-2455	178	42	curation	curation	NOUN
eurjchem-2455	178	43	:	:	PUNCT
eurjchem-2455	178	44	mohammad	mohammad	PROPN
eurjchem-2455	178	45	suhail	suhail	PROPN
eurjchem-2455	178	46	;	;	PUNCT
eurjchem-2455	178	47	writing	write	VERB
eurjchem-2455	178	48	–	–	PUNCT
eurjchem-2455	178	49	original	original	ADJ
eurjchem-2455	178	50	draft	draft	NOUN
eurjchem-2455	178	51	:	:	PUNCT
eurjchem-2455	178	52	mohammad	mohammad	PROPN
eurjchem-2455	178	53	suhail	suhail	PROPN
eurjchem-2455	178	54	;	;	PUNCT
eurjchem-2455	178	55	writing	write	VERB
eurjchem-2455	178	56	review	review	NOUN
eurjchem-2455	178	57	and	and	CCONJ
eurjchem-2455	178	58	editing	editing	NOUN
eurjchem-2455	178	59	:	:	PUNCT
eurjchem-2455	178	60	mohammad	mohammad	PROPN
eurjchem-2455	178	61	suhail	suhail	PROPN
eurjchem-2455	178	62	;	;	PUNCT
eurjchem-2455	178	63	visualization	visualization	NOUN
eurjchem-2455	178	64	:	:	PUNCT
eurjchem-2455	178	65	mehmood	mehmood	PROPN
eurjchem-2455	178	66	ahmad	ahmad	PROPN
eurjchem-2455	178	67	;	;	PUNCT
eurjchem-2455	178	68	funding	funding	NOUN
eurjchem-2455	178	69	acquisition	acquisition	NOUN
eurjchem-2455	178	70	:	:	PUNCT
eurjchem-2455	178	71	mohammad	mohammad	PROPN
eurjchem-2455	178	72	suhail	suhail	PROPN
eurjchem-2455	178	73	;	;	PUNCT
eurjchem-2455	178	74	supervision	supervision	NOUN
eurjchem-2455	178	75	:	:	PUNCT
eurjchem-2455	178	76	mohammad	mohammad	PROPN
eurjchem-2455	178	77	suhail	suhail	PROPN
eurjchem-2455	178	78	;	;	PUNCT
eurjchem-2455	178	79	project	project	NOUN
eurjchem-2455	178	80	administration	administration	NOUN
eurjchem-2455	178	81	:	:	PUNCT
eurjchem-2455	178	82	mohammad	mohammad	PROPN
eurjchem-2455	178	83	suhail	suhail	PROPN
eurjchem-2455	178	84	.	.	PUNCT
eurjchem-2455	179	1	orcid	orcid	NOUN
eurjchem-2455	179	2	and	and	CCONJ
eurjchem-2455	179	3	email	email	NOUN
eurjchem-2455	179	4	mohd	mohd	PROPN
eurjchem-2455	179	5	suhail	suhail	PROPN
eurjchem-2455	179	6	suhailchem.786@gmail.com	suhailchem.786@gmail.com	PROPN
eurjchem-2455	180	1	https://orcid.org/0000-0003-1836-6951	https://orcid.org/0000-0003-1836-6951	PROPN
eurjchem-2455	180	2	safwana	safwana	PROPN
eurjchem-2455	180	3	usmani	usmani	PROPN
eurjchem-2455	180	4	usmanisafwana@gmail.com	usmanisafwana@gmail.com	PROPN
eurjchem-2455	181	1	https://orcid.org/0009-0006-6648-3799	https://orcid.org/0009-0006-6648-3799	PROPN
eurjchem-2455	181	2	mehmood	mehmood	PROPN
eurjchem-2455	181	3	ahmad	ahmad	PROPN
eurjchem-2455	181	4	ahmadchem123@gmail.com	ahmadchem123@gmail.com	PROPN
eurjchem-2455	182	1	https://orcid.org/0009-0001-9029-9274	https://orcid.org/0009-0001-9029-9274	PROPN
eurjchem-2455	182	2	references	reference	NOUN
eurjchem-2455	182	3	[	[	X
eurjchem-2455	182	4	1	1	NUM
eurjchem-2455	182	5	]	]	PUNCT
eurjchem-2455	182	6	.	.	PUNCT
eurjchem-2455	183	1	pauling	pauling	PROPN
eurjchem-2455	183	2	,	,	PUNCT
eurjchem-2455	183	3	l.	l.	PROPN
eurjchem-2455	183	4	;	;	PUNCT
eurjchem-2455	183	5	itano	itano	PROPN
eurjchem-2455	183	6	,	,	PUNCT
eurjchem-2455	183	7	h.	h.	PROPN
eurjchem-2455	183	8	a.	a.	PROPN
eurjchem-2455	183	9	;	;	PUNCT
eurjchem-2455	183	10	singer	singer	NOUN
eurjchem-2455	183	11	,	,	PUNCT
eurjchem-2455	183	12	s.	s.	PROPN
eurjchem-2455	183	13	j.	j.	PROPN
eurjchem-2455	183	14	;	;	PUNCT
eurjchem-2455	183	15	wells	wells	PROPN
eurjchem-2455	183	16	,	,	PUNCT
eurjchem-2455	183	17	i.	i.	PROPN
eurjchem-2455	183	18	c.	c.	PROPN
eurjchem-2455	183	19	sickle	sickle	PROPN
eurjchem-2455	183	20	cell	cell	PROPN
eurjchem-2455	183	21	anemia	anemia	NOUN
eurjchem-2455	183	22	,	,	PUNCT
eurjchem-2455	183	23	a	a	DET
eurjchem-2455	183	24	molecular	molecular	ADJ
eurjchem-2455	183	25	disease	disease	NOUN
eurjchem-2455	183	26	.	.	PUNCT
eurjchem-2455	184	1	science	science	NOUN
eurjchem-2455	184	2	1949	1949	NUM
eurjchem-2455	184	3	,	,	PUNCT
eurjchem-2455	184	4	110	110	NUM
eurjchem-2455	184	5	,	,	PUNCT
eurjchem-2455	184	6	543–548	543–548	NUM
eurjchem-2455	184	7	.	.	PUNCT
eurjchem-2455	185	1	[	[	X
eurjchem-2455	185	2	2	2	NUM
eurjchem-2455	185	3	]	]	PUNCT
eurjchem-2455	185	4	.	.	PUNCT
eurjchem-2455	186	1	ingram	ingram	PROPN
eurjchem-2455	186	2	,	,	PUNCT
eurjchem-2455	186	3	v.	v.	ADP
eurjchem-2455	186	4	m.	m.	NOUN
eurjchem-2455	186	5	gene	gene	NOUN
eurjchem-2455	186	6	mutations	mutation	NOUN
eurjchem-2455	186	7	in	in	ADP
eurjchem-2455	186	8	human	human	ADJ
eurjchem-2455	186	9	hæmoglobin	hæmoglobin	PROPN
eurjchem-2455	186	10	:	:	PUNCT
eurjchem-2455	186	11	the	the	DET
eurjchem-2455	186	12	chemical	chemical	ADJ
eurjchem-2455	186	13	difference	difference	NOUN
eurjchem-2455	186	14	between	between	ADP
eurjchem-2455	186	15	normal	normal	ADJ
eurjchem-2455	186	16	and	and	CCONJ
eurjchem-2455	186	17	sickle	sickle	PROPN
eurjchem-2455	186	18	cell	cell	NOUN
eurjchem-2455	186	19	hæmoglobin	hæmoglobin	PROPN
eurjchem-2455	186	20	.	.	PUNCT
eurjchem-2455	187	1	nature	nature	NOUN
eurjchem-2455	187	2	1957	1957	NUM
eurjchem-2455	187	3	,	,	PUNCT
eurjchem-2455	187	4	180	180	NUM
eurjchem-2455	187	5	,	,	PUNCT
eurjchem-2455	187	6	326–328	326–328	NUM
eurjchem-2455	187	7	.	.	PUNCT
eurjchem-2455	188	1	[	[	X
eurjchem-2455	188	2	3	3	NUM
eurjchem-2455	188	3	]	]	PUNCT
eurjchem-2455	188	4	.	.	PUNCT
eurjchem-2455	189	1	may	may	AUX
eurjchem-2455	189	2	,	,	PUNCT
eurjchem-2455	189	3	a.	a.	NOUN
eurjchem-2455	189	4	;	;	PUNCT
eurjchem-2455	189	5	huehns	huehns	PROPN
eurjchem-2455	189	6	,	,	PUNCT
eurjchem-2455	189	7	e.	e.	PROPN
eurjchem-2455	189	8	r.	r.	PROPN
eurjchem-2455	189	9	the	the	DET
eurjchem-2455	189	10	mechanism	mechanism	NOUN
eurjchem-2455	189	11	of	of	ADP
eurjchem-2455	189	12	the	the	DET
eurjchem-2455	189	13	low	low	ADJ
eurjchem-2455	189	14	oxygen	oxygen	NOUN
eurjchem-2455	189	15	affinity	affinity	NOUN
eurjchem-2455	189	16	of	of	ADP
eurjchem-2455	189	17	red	red	ADJ
eurjchem-2455	189	18	cells	cell	NOUN
eurjchem-2455	189	19	in	in	ADP
eurjchem-2455	189	20	sickle	sickle	NOUN
eurjchem-2455	189	21	cell	cell	NOUN
eurjchem-2455	189	22	disease	disease	NOUN
eurjchem-2455	189	23	.	.	PUNCT
eurjchem-2455	190	1	hamatol	hamatol	NOUN
eurjchem-2455	190	2	.	.	PUNCT
eurjchem-2455	191	1	bluttransfus	bluttransfus	NOUN
eurjchem-2455	191	2	.	.	PUNCT
eurjchem-2455	192	1	1972	1972	NUM
eurjchem-2455	192	2	,	,	PUNCT
eurjchem-2455	192	3	10	10	NUM
eurjchem-2455	192	4	,	,	PUNCT
eurjchem-2455	192	5	279–283	279–283	NUM
eurjchem-2455	192	6	.	.	PUNCT
eurjchem-2455	193	1	[	[	X
eurjchem-2455	193	2	4	4	NUM
eurjchem-2455	193	3	]	]	PUNCT
eurjchem-2455	193	4	.	.	PUNCT
eurjchem-2455	193	5	becklake	becklake	PROPN
eurjchem-2455	193	6	,	,	PUNCT
eurjchem-2455	193	7	m.	m.	NOUN
eurjchem-2455	193	8	r.	r.	PROPN
eurjchem-2455	193	9	;	;	PUNCT
eurjchem-2455	193	10	griffiths	griffiths	PROPN
eurjchem-2455	193	11	,	,	PUNCT
eurjchem-2455	193	12	s.	s.	PROPN
eurjchem-2455	193	13	b.	b.	PROPN
eurjchem-2455	193	14	;	;	PUNCT
eurjchem-2455	193	15	mcgregor	mcgregor	PROPN
eurjchem-2455	193	16	,	,	PUNCT
eurjchem-2455	193	17	m.	m.	NOUN
eurjchem-2455	193	18	;	;	PUNCT
eurjchem-2455	193	19	goldman	goldman	PROPN
eurjchem-2455	193	20	,	,	PUNCT
eurjchem-2455	193	21	h.	h.	PROPN
eurjchem-2455	193	22	i.	i.	PROPN
eurjchem-2455	193	23	;	;	PUNCT
eurjchem-2455	193	24	schreve	schreve	PROPN
eurjchem-2455	193	25	,	,	PUNCT
eurjchem-2455	193	26	j.	j.	PROPN
eurjchem-2455	193	27	p.	p.	NOUN
eurjchem-2455	193	28	oxygen	oxygen	NOUN
eurjchem-2455	193	29	dissociation	dissociation	NOUN
eurjchem-2455	193	30	curves	curve	NOUN
eurjchem-2455	193	31	in	in	ADP
eurjchem-2455	193	32	sickle	sickle	NOUN
eurjchem-2455	193	33	cell	cell	NOUN
eurjchem-2455	193	34	anemia	anemia	NOUN
eurjchem-2455	193	35	and	and	CCONJ
eurjchem-2455	193	36	in	in	ADP
eurjchem-2455	193	37	subjects	subject	NOUN
eurjchem-2455	193	38	with	with	ADP
eurjchem-2455	193	39	the	the	DET
eurjchem-2455	193	40	sickle	sickle	NOUN
eurjchem-2455	193	41	cell	cell	NOUN
eurjchem-2455	193	42	trait	trait	NOUN
eurjchem-2455	193	43	.	.	PUNCT
eurjchem-2455	194	1	j.	j.	PROPN
eurjchem-2455	194	2	clin	clin	PROPN
eurjchem-2455	194	3	.	.	PUNCT
eurjchem-2455	195	1	invest	invest	PROPN
eurjchem-2455	195	2	.	.	PUNCT
eurjchem-2455	196	1	1955	1955	NUM
eurjchem-2455	196	2	,	,	PUNCT
eurjchem-2455	196	3	34	34	NUM
eurjchem-2455	196	4	,	,	PUNCT
eurjchem-2455	196	5	751–755	751–755	NUM
eurjchem-2455	196	6	.	.	PUNCT
eurjchem-2455	197	1	[	[	X
eurjchem-2455	197	2	5	5	NUM
eurjchem-2455	197	3	]	]	PUNCT
eurjchem-2455	197	4	.	.	PUNCT
eurjchem-2455	197	5	fabry	fabry	PROPN
eurjchem-2455	197	6	,	,	PUNCT
eurjchem-2455	197	7	m.	m.	PROPN
eurjchem-2455	197	8	e.	e.	PROPN
eurjchem-2455	197	9	;	;	PUNCT
eurjchem-2455	197	10	desrosiers	desrosier	NOUN
eurjchem-2455	197	11	,	,	PUNCT
eurjchem-2455	197	12	l.	l.	PROPN
eurjchem-2455	197	13	;	;	PUNCT
eurjchem-2455	197	14	suzuka	suzuka	PROPN
eurjchem-2455	197	15	,	,	PUNCT
eurjchem-2455	197	16	s.	s.	PROPN
eurjchem-2455	197	17	m.	m.	PROPN
eurjchem-2455	197	18	direct	direct	ADJ
eurjchem-2455	197	19	intracellular	intracellular	ADJ
eurjchem-2455	197	20	measurement	measurement	NOUN
eurjchem-2455	197	21	of	of	ADP
eurjchem-2455	197	22	deoxygenated	deoxygenate	VERB
eurjchem-2455	197	23	hemoglobin	hemoglobin	NOUN
eurjchem-2455	197	24	s	s	PART
eurjchem-2455	197	25	solubility	solubility	NOUN
eurjchem-2455	197	26	.	.	PUNCT
eurjchem-2455	198	1	blood	blood	NOUN
eurjchem-2455	198	2	2001	2001	NUM
eurjchem-2455	198	3	,	,	PUNCT
eurjchem-2455	198	4	98	98	NUM
eurjchem-2455	198	5	,	,	PUNCT
eurjchem-2455	198	6	883–884	883–884	NUM
eurjchem-2455	198	7	.	.	PUNCT
eurjchem-2455	199	1	[	[	X
eurjchem-2455	199	2	6	6	NUM
eurjchem-2455	199	3	]	]	PUNCT
eurjchem-2455	199	4	.	.	PUNCT
eurjchem-2455	200	1	gill	gill	PROPN
eurjchem-2455	200	2	,	,	PUNCT
eurjchem-2455	200	3	s.	s.	PROPN
eurjchem-2455	200	4	j.	j.	PROPN
eurjchem-2455	200	5	;	;	PUNCT
eurjchem-2455	200	6	sköld	sköld	NOUN
eurjchem-2455	200	7	,	,	PUNCT
eurjchem-2455	200	8	r.	r.	PROPN
eurjchem-2455	200	9	;	;	PUNCT
eurjchem-2455	200	10	fall	fall	NOUN
eurjchem-2455	200	11	,	,	PUNCT
eurjchem-2455	200	12	l.	l.	PROPN
eurjchem-2455	200	13	;	;	PUNCT
eurjchem-2455	200	14	shaeffer	shaeffer	NOUN
eurjchem-2455	200	15	,	,	PUNCT
eurjchem-2455	200	16	t.	t.	PROPN
eurjchem-2455	200	17	;	;	PUNCT
eurjchem-2455	200	18	spokane	spokane	PROPN
eurjchem-2455	200	19	,	,	PUNCT
eurjchem-2455	200	20	p.	p.	PROPN
eurjchem-2455	200	21	;	;	PUNCT
eurjchem-2455	200	22	wyman	wyman	NOUN
eurjchem-2455	200	23	,	,	PUNCT
eurjchem-2455	200	24	j.	j.	PROPN
eurjchem-2455	200	25	aggregation	aggregation	NOUN
eurjchem-2455	200	26	effects	effect	NOUN
eurjchem-2455	200	27	on	on	ADP
eurjchem-2455	200	28	oxygen	oxygen	NOUN
eurjchem-2455	200	29	binding	binding	NOUN
eurjchem-2455	200	30	of	of	ADP
eurjchem-2455	200	31	sickle	sickle	PROPN
eurjchem-2455	200	32	cell	cell	NOUN
eurjchem-2455	200	33	hemoglobin	hemoglobin	NOUN
eurjchem-2455	200	34	.	.	PUNCT
eurjchem-2455	201	1	science	science	NOUN
eurjchem-2455	201	2	1978	1978	NUM
eurjchem-2455	201	3	,	,	PUNCT
eurjchem-2455	201	4	201	201	NUM
eurjchem-2455	201	5	,	,	PUNCT
eurjchem-2455	201	6	362–364	362–364	NUM
eurjchem-2455	201	7	.	.	PUNCT
eurjchem-2455	202	1	[	[	X
eurjchem-2455	202	2	7	7	NUM
eurjchem-2455	202	3	]	]	PUNCT
eurjchem-2455	202	4	.	.	PUNCT
eurjchem-2455	203	1	adachi	adachi	PROPN
eurjchem-2455	203	2	,	,	PUNCT
eurjchem-2455	203	3	k.	k.	PROPN
eurjchem-2455	203	4	;	;	PUNCT
eurjchem-2455	203	5	konitzer	konitzer	PROPN
eurjchem-2455	203	6	,	,	PUNCT
eurjchem-2455	203	7	p.	p.	NOUN
eurjchem-2455	203	8	;	;	PUNCT
eurjchem-2455	203	9	paulraj	paulraj	PROPN
eurjchem-2455	203	10	,	,	PUNCT
eurjchem-2455	203	11	c.	c.	PROPN
eurjchem-2455	203	12	g.	g.	PROPN
eurjchem-2455	203	13	;	;	PUNCT
eurjchem-2455	203	14	surrey	surrey	PROPN
eurjchem-2455	203	15	,	,	PUNCT
eurjchem-2455	203	16	s.	s.	PROPN
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eurjchem-2455	203	20	-	-	PROPN
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eurjchem-2455	203	22	88	88	NUM
eurjchem-2455	203	23	in	in	ADP
eurjchem-2455	203	24	the	the	DET
eurjchem-2455	203	25	hydrophobic	hydrophobic	NOUN
eurjchem-2455	203	26	acceptor	acceptor	NOUN
eurjchem-2455	203	27	pocket	pocket	NOUN
eurjchem-2455	203	28	for	for	ADP
eurjchem-2455	203	29	val	val	NOUN
eurjchem-2455	203	30	-	-	PUNCT
eurjchem-2455	203	31	beta	beta	ADJ
eurjchem-2455	203	32	6	6	NUM
eurjchem-2455	203	33	during	during	ADP
eurjchem-2455	203	34	hemoglobin	hemoglobin	NOUN
eurjchem-2455	203	35	s	s	PART
eurjchem-2455	203	36	polymerization	polymerization	NOUN
eurjchem-2455	203	37	.	.	PUNCT
eurjchem-2455	204	1	j.	j.	PROPN
eurjchem-2455	204	2	biol	biol	PROPN
eurjchem-2455	204	3	.	.	PUNCT
eurjchem-2455	205	1	chem	chem	PROPN
eurjchem-2455	205	2	.	.	PUNCT
eurjchem-2455	206	1	1994	1994	NUM
eurjchem-2455	206	2	,	,	PUNCT
eurjchem-2455	206	3	269	269	NUM
eurjchem-2455	206	4	,	,	PUNCT
eurjchem-2455	206	5	17477–17480	17477–17480	NUM
eurjchem-2455	206	6	.	.	PUNCT
eurjchem-2455	207	1	[	[	X
eurjchem-2455	207	2	8	8	NUM
eurjchem-2455	207	3	]	]	PUNCT
eurjchem-2455	207	4	.	.	PUNCT
eurjchem-2455	208	1	ferrone	ferrone	NOUN
eurjchem-2455	208	2	,	,	PUNCT
eurjchem-2455	208	3	f.	f.	PROPN
eurjchem-2455	208	4	a.	a.	PROPN
eurjchem-2455	208	5	;	;	PUNCT
eurjchem-2455	208	6	ivanova	ivanova	PROPN
eurjchem-2455	208	7	,	,	PUNCT
eurjchem-2455	208	8	m.	m.	NOUN
eurjchem-2455	208	9	;	;	PUNCT
eurjchem-2455	208	10	jasuja	jasuja	PROPN
eurjchem-2455	208	11	,	,	PUNCT
eurjchem-2455	208	12	r.	r.	PROPN
eurjchem-2455	208	13	heterogeneous	heterogeneous	ADJ
eurjchem-2455	208	14	nucleation	nucleation	NOUN
eurjchem-2455	208	15	and	and	CCONJ
eurjchem-2455	208	16	crowding	crowd	VERB
eurjchem-2455	208	17	in	in	ADP
eurjchem-2455	208	18	sickle	sickle	NOUN
eurjchem-2455	208	19	hemoglobin	hemoglobin	NOUN
eurjchem-2455	208	20	:	:	PUNCT
eurjchem-2455	208	21	an	an	DET
eurjchem-2455	208	22	analytic	analytic	ADJ
eurjchem-2455	208	23	approach	approach	NOUN
eurjchem-2455	208	24	.	.	PUNCT
eurjchem-2455	209	1	biophys	biophy	NOUN
eurjchem-2455	209	2	.	.	PUNCT
eurjchem-2455	210	1	j.	j.	PROPN
eurjchem-2455	210	2	2002	2002	PROPN
eurjchem-2455	210	3	,	,	PUNCT
eurjchem-2455	210	4	82	82	NUM
eurjchem-2455	210	5	,	,	PUNCT
eurjchem-2455	210	6	399–406	399–406	NUM
eurjchem-2455	210	7	.	.	PUNCT
eurjchem-2455	211	1	[	[	X
eurjchem-2455	211	2	9	9	NUM
eurjchem-2455	211	3	]	]	PUNCT
eurjchem-2455	211	4	.	.	PUNCT
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eurjchem-2455	211	6	,	,	PUNCT
eurjchem-2455	211	7	b.	b.	PROPN
eurjchem-2455	211	8	;	;	PUNCT
eurjchem-2455	211	9	archana	archana	PROPN
eurjchem-2455	211	10	,	,	PUNCT
eurjchem-2455	211	11	y.	y.	PROPN
eurjchem-2455	211	12	;	;	PUNCT
eurjchem-2455	211	13	satapathy	satapathy	ADJ
eurjchem-2455	211	14	,	,	PUNCT
eurjchem-2455	211	15	n.	n.	NOUN
eurjchem-2455	211	16	;	;	PUNCT
eurjchem-2455	211	17	naik	naik	PROPN
eurjchem-2455	211	18	,	,	PUNCT
eurjchem-2455	211	19	s.	s.	PROPN
eurjchem-2455	211	20	search	search	VERB
eurjchem-2455	211	21	for	for	ADP
eurjchem-2455	211	22	antisickling	antisickle	VERB
eurjchem-2455	211	23	agents	agent	NOUN
eurjchem-2455	211	24	from	from	ADP
eurjchem-2455	211	25	plants	plant	NOUN
eurjchem-2455	211	26	.	.	PUNCT
eurjchem-2455	212	1	pharmacogn	pharmacogn	PROPN
eurjchem-2455	212	2	.	.	PUNCT
eurjchem-2455	213	1	rev	rev	PROPN
eurjchem-2455	213	2	.	.	PROPN
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eurjchem-2455	213	4	,	,	PUNCT
eurjchem-2455	213	5	7	7	NUM
eurjchem-2455	213	6	,	,	PUNCT
eurjchem-2455	213	7	53	53	NUM
eurjchem-2455	213	8	.	.	PUNCT
eurjchem-2455	214	1	[	[	X
eurjchem-2455	214	2	10	10	NUM
eurjchem-2455	214	3	]	]	PUNCT
eurjchem-2455	214	4	.	.	PUNCT
eurjchem-2455	215	1	marengo	marengo	PROPN
eurjchem-2455	215	2	-	-	PUNCT
eurjchem-2455	215	3	rowe	rowe	PROPN
eurjchem-2455	215	4	,	,	PUNCT
eurjchem-2455	215	5	a.	a.	PROPN
eurjchem-2455	215	6	j.	j.	PROPN
eurjchem-2455	215	7	structure	structure	NOUN
eurjchem-2455	215	8	-	-	PUNCT
eurjchem-2455	215	9	function	function	NOUN
eurjchem-2455	215	10	relations	relation	NOUN
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eurjchem-2455	215	13	hemoglobins	hemoglobin	NOUN
eurjchem-2455	215	14	.	.	PUNCT
eurjchem-2455	216	1	proc	proc	NOUN
eurjchem-2455	216	2	.	.	PUNCT
eurjchem-2455	217	1	(	(	PUNCT
eurjchem-2455	217	2	bayl	bayl	NOUN
eurjchem-2455	217	3	.	.	PUNCT
eurjchem-2455	218	1	univ	univ	AUX
eurjchem-2455	218	2	.	.	PUNCT
eurjchem-2455	218	3	med	med	PROPN
eurjchem-2455	218	4	.	.	PUNCT
eurjchem-2455	218	5	cent	cent	NOUN
eurjchem-2455	218	6	.	.	PUNCT
eurjchem-2455	218	7	)	)	PUNCT
eurjchem-2455	219	1	2006	2006	NUM
eurjchem-2455	219	2	,	,	PUNCT
eurjchem-2455	219	3	19	19	NUM
eurjchem-2455	219	4	,	,	PUNCT
eurjchem-2455	219	5	239–245	239–245	NUM
eurjchem-2455	219	6	.	.	PUNCT
eurjchem-2455	220	1	[	[	X
eurjchem-2455	220	2	11	11	NUM
eurjchem-2455	220	3	]	]	PUNCT
eurjchem-2455	220	4	.	.	PUNCT
eurjchem-2455	221	1	rotter	rotter	NOUN
eurjchem-2455	221	2	,	,	PUNCT
eurjchem-2455	221	3	m.	m.	NOUN
eurjchem-2455	221	4	a.	a.	PROPN
eurjchem-2455	221	5	;	;	PUNCT
eurjchem-2455	221	6	kwong	kwong	PROPN
eurjchem-2455	221	7	,	,	PUNCT
eurjchem-2455	221	8	s.	s.	PROPN
eurjchem-2455	221	9	;	;	PUNCT
eurjchem-2455	221	10	briehl	briehl	PROPN
eurjchem-2455	221	11	,	,	PUNCT
eurjchem-2455	221	12	r.	r.	PROPN
eurjchem-2455	221	13	w.	w.	PROPN
eurjchem-2455	221	14	;	;	PUNCT
eurjchem-2455	221	15	ferrone	ferrone	NOUN
eurjchem-2455	221	16	,	,	PUNCT
eurjchem-2455	221	17	f.	f.	PROPN
eurjchem-2455	221	18	a.	a.	PROPN
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eurjchem-2455	221	20	nucleation	nucleation	NOUN
eurjchem-2455	221	21	in	in	ADP
eurjchem-2455	221	22	sickle	sickle	NOUN
eurjchem-2455	221	23	hemoglobin	hemoglobin	NOUN
eurjchem-2455	221	24	:	:	PUNCT
eurjchem-2455	221	25	experimental	experimental	ADJ
eurjchem-2455	221	26	validation	validation	NOUN
eurjchem-2455	221	27	of	of	ADP
eurjchem-2455	221	28	a	a	DET
eurjchem-2455	221	29	structural	structural	ADJ
eurjchem-2455	221	30	mechanism	mechanism	NOUN
eurjchem-2455	221	31	.	.	PUNCT
eurjchem-2455	222	1	biophys	biophy	NOUN
eurjchem-2455	222	2	.	.	PUNCT
eurjchem-2455	223	1	j.	j.	PROPN
eurjchem-2455	223	2	2005	2005	NUM
eurjchem-2455	223	3	,	,	PUNCT
eurjchem-2455	223	4	89	89	NUM
eurjchem-2455	223	5	,	,	PUNCT
eurjchem-2455	223	6	2677–2684	2677–2684	NUM
eurjchem-2455	223	7	.	.	PUNCT
eurjchem-2455	224	1	[	[	X
eurjchem-2455	224	2	12	12	NUM
eurjchem-2455	224	3	]	]	PUNCT
eurjchem-2455	224	4	.	.	PUNCT
eurjchem-2455	225	1	martin	martin	PROPN
eurjchem-2455	225	2	,	,	PUNCT
eurjchem-2455	225	3	d.	d.	PROPN
eurjchem-2455	225	4	w.	w.	PROPN
eurjchem-2455	225	5	;	;	PUNCT
eurjchem-2455	225	6	mayes	mayes	PROPN
eurjchem-2455	225	7	,	,	PUNCT
eurjchem-2455	225	8	p.	p.	NOUN
eurjchem-2455	225	9	a.	a.	NOUN
eurjchem-2455	225	10	;	;	PUNCT
eurjchem-2455	225	11	rodwell	rodwell	PROPN
eurjchem-2455	225	12	,	,	PUNCT
eurjchem-2455	225	13	v.	v.	PROPN
eurjchem-2455	225	14	w.	w.	PROPN
eurjchem-2455	225	15	harper	harper	PROPN
eurjchem-2455	225	16	’s	’s	PART
eurjchem-2455	225	17	review	review	NOUN
eurjchem-2455	225	18	of	of	ADP
eurjchem-2455	225	19	biochemistry	biochemistry	NOUN
eurjchem-2455	225	20	;	;	PUNCT
eurjchem-2455	225	21	lange	lange	PROPN
eurjchem-2455	225	22	medical	medical	ADJ
eurjchem-2455	225	23	publications	publication	NOUN
eurjchem-2455	225	24	:	:	PUNCT
eurjchem-2455	225	25	california	california	PROPN
eurjchem-2455	225	26	,	,	PUNCT
eurjchem-2455	225	27	1981	1981	NUM
eurjchem-2455	225	28	.	.	PUNCT
eurjchem-2455	226	1	[	[	X
eurjchem-2455	226	2	13	13	NUM
eurjchem-2455	226	3	]	]	PUNCT
eurjchem-2455	226	4	.	.	PUNCT
eurjchem-2455	227	1	abdulmalik	abdulmalik	PROPN
eurjchem-2455	227	2	,	,	PUNCT
eurjchem-2455	227	3	o.	o.	PROPN
eurjchem-2455	227	4	;	;	PUNCT
eurjchem-2455	227	5	pagare	pagare	PROPN
eurjchem-2455	227	6	,	,	PUNCT
eurjchem-2455	227	7	p.	p.	PROPN
eurjchem-2455	227	8	p.	p.	PROPN
eurjchem-2455	227	9	;	;	PUNCT
eurjchem-2455	227	10	huang	huang	PROPN
eurjchem-2455	227	11	,	,	PUNCT
eurjchem-2455	227	12	b.	b.	PROPN
eurjchem-2455	227	13	;	;	PUNCT
eurjchem-2455	227	14	xu	xu	PROPN
eurjchem-2455	227	15	,	,	PUNCT
eurjchem-2455	227	16	g.	g.	PROPN
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eurjchem-2455	227	18	;	;	PUNCT
eurjchem-2455	227	19	ghatge	ghatge	VERB
eurjchem-2455	227	20	,	,	PUNCT
eurjchem-2455	227	21	m.	m.	NOUN
eurjchem-2455	227	22	s.	s.	PROPN
eurjchem-2455	227	23	;	;	PUNCT
eurjchem-2455	227	24	xu	xu	PROPN
eurjchem-2455	227	25	,	,	PUNCT
eurjchem-2455	227	26	x.	x.	PROPN
eurjchem-2455	227	27	;	;	PUNCT
eurjchem-2455	228	1	chen	chen	PROPN
eurjchem-2455	228	2	,	,	PUNCT
eurjchem-2455	228	3	q.	q.	PROPN
eurjchem-2455	228	4	;	;	PUNCT
eurjchem-2455	228	5	anabaraonye	anabaraonye	NOUN
eurjchem-2455	228	6	,	,	PUNCT
eurjchem-2455	228	7	n.	n.	NOUN
eurjchem-2455	228	8	;	;	PUNCT
eurjchem-2455	228	9	musayev	musayev	PROPN
eurjchem-2455	228	10	,	,	PUNCT
eurjchem-2455	228	11	f.	f.	PROPN
eurjchem-2455	228	12	n.	n.	PROPN
eurjchem-2455	228	13	;	;	PUNCT
eurjchem-2455	228	14	omar	omar	PROPN
eurjchem-2455	228	15	,	,	PUNCT
eurjchem-2455	228	16	a.	a.	NOUN
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eurjchem-2455	228	18	;	;	PUNCT
eurjchem-2455	228	19	venitz	venitz	PROPN
eurjchem-2455	228	20	,	,	PUNCT
eurjchem-2455	228	21	j.	j.	PROPN
eurjchem-2455	228	22	;	;	PUNCT
eurjchem-2455	228	23	zhang	zhang	PROPN
eurjchem-2455	228	24	,	,	PUNCT
eurjchem-2455	228	25	y.	y.	PROPN
eurjchem-2455	228	26	;	;	PUNCT
eurjchem-2455	228	27	safo	safo	PROPN
eurjchem-2455	228	28	,	,	PUNCT
eurjchem-2455	228	29	m.	m.	PROPN
eurjchem-2455	228	30	k.	k.	PROPN
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eurjchem-2455	228	36	agent	agent	NOUN
eurjchem-2455	228	37	that	that	PRON
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eurjchem-2455	228	39	erythrocyte	erythrocyte	NOUN
eurjchem-2455	228	40	sickling	sickle	VERB
eurjchem-2455	228	41	under	under	ADP
eurjchem-2455	228	42	both	both	CCONJ
eurjchem-2455	228	43	hypoxic	hypoxic	ADJ
eurjchem-2455	228	44	and	and	CCONJ
eurjchem-2455	228	45	anoxic	anoxic	ADJ
eurjchem-2455	228	46	conditions	condition	NOUN
eurjchem-2455	228	47	.	.	PUNCT
eurjchem-2455	229	1	sci	sci	PROPN
eurjchem-2455	229	2	.	.	PROPN
eurjchem-2455	229	3	rep	rep	PROPN
eurjchem-2455	229	4	.	.	PROPN
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eurjchem-2455	229	6	,	,	PUNCT
eurjchem-2455	229	7	10	10	NUM
eurjchem-2455	229	8	,	,	PUNCT
eurjchem-2455	229	9	20277	20277	NUM
eurjchem-2455	229	10	.	.	PUNCT
eurjchem-2455	230	1	[	[	X
eurjchem-2455	230	2	14	14	NUM
eurjchem-2455	230	3	]	]	SYM
eurjchem-2455	230	4	.	.	PUNCT
eurjchem-2455	231	1	zaugg	zaugg	NOUN
eurjchem-2455	231	2	,	,	PUNCT
eurjchem-2455	231	3	r.	r.	PROPN
eurjchem-2455	231	4	h.	h.	PROPN
eurjchem-2455	231	5	;	;	PUNCT
eurjchem-2455	231	6	walder	walder	NOUN
eurjchem-2455	231	7	,	,	PUNCT
eurjchem-2455	231	8	j.	j.	PROPN
eurjchem-2455	231	9	a.	a.	PROPN
eurjchem-2455	231	10	;	;	PUNCT
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eurjchem-2455	235	6	.	.	PUNCT
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eurjchem-2455	244	12	(	(	PUNCT
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eurjchem-2455	244	15	(	(	PUNCT
eurjchem-2455	244	16	2023	2023	NUM
eurjchem-2455	244	17	)	)	PUNCT
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eurjchem-2455	244	23	–	–	PUNCT
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eurjchem-2455	245	3	]	]	PUNCT
eurjchem-2455	245	4	.	.	PUNCT
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eurjchem-2455	248	1	[	[	X
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eurjchem-2455	249	28	;	;	PUNCT
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eurjchem-2455	253	6	.	.	PUNCT
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eurjchem-2455	259	7	d.	d.	PROPN
eurjchem-2455	259	8	;	;	PUNCT
eurjchem-2455	259	9	mckew	mckew	NOUN
eurjchem-2455	259	10	,	,	PUNCT
eurjchem-2455	259	11	j.	j.	PROPN
eurjchem-2455	259	12	;	;	PUNCT
eurjchem-2455	259	13	shen	shen	PROPN
eurjchem-2455	259	14	,	,	PUNCT
eurjchem-2455	259	15	x.	x.	PROPN
eurjchem-2455	259	16	;	;	PUNCT
eurjchem-2455	259	17	kato	kato	PROPN
eurjchem-2455	259	18	,	,	PUNCT
eurjchem-2455	259	19	g.	g.	PROPN
eurjchem-2455	259	20	j.	j.	PROPN
eurjchem-2455	260	1	a	a	DET
eurjchem-2455	260	2	phase	phase	NOUN
eurjchem-2455	260	3	1	1	NUM
eurjchem-2455	260	4	,	,	PUNCT
eurjchem-2455	260	5	firstin	firstin	NOUN
eurjchem-2455	260	6	-	-	PUNCT
eurjchem-2455	260	7	man	man	NOUN
eurjchem-2455	260	8	,	,	PUNCT
eurjchem-2455	260	9	dose	dose	NOUN
eurjchem-2455	260	10	-	-	PUNCT
eurjchem-2455	260	11	response	response	NOUN
eurjchem-2455	260	12	study	study	NOUN
eurjchem-2455	260	13	of	of	ADP
eurjchem-2455	260	14	aes-103	aes-103	ADJ
eurjchem-2455	260	15	(	(	PUNCT
eurjchem-2455	260	16	5	5	NUM
eurjchem-2455	260	17	-	-	PUNCT
eurjchem-2455	260	18	hmf	hmf	NOUN
eurjchem-2455	260	19	)	)	PUNCT
eurjchem-2455	260	20	,	,	PUNCT
eurjchem-2455	260	21	an	an	DET
eurjchem-2455	260	22	anti	anti	ADJ
eurjchem-2455	260	23	-	-	ADJ
eurjchem-2455	260	24	sickling	sickling	ADJ
eurjchem-2455	260	25	,	,	PUNCT
eurjchem-2455	260	26	allosteric	allosteric	ADJ
eurjchem-2455	260	27	modifier	modifier	NOUN
eurjchem-2455	260	28	of	of	ADP
eurjchem-2455	260	29	hemoglobin	hemoglobin	NOUN
eurjchem-2455	260	30	oxygen	oxygen	NOUN
eurjchem-2455	260	31	affinity	affinity	NOUN
eurjchem-2455	260	32	in	in	ADP
eurjchem-2455	260	33	healthy	healthy	ADJ
eurjchem-2455	260	34	norman	norman	PROPN
eurjchem-2455	260	35	volunteers	volunteers	PROPN
eurjchem-2455	260	36	.	.	PUNCT
eurjchem-2455	261	1	blood	blood	NOUN
eurjchem-2455	261	2	2012	2012	NUM
eurjchem-2455	261	3	,	,	PUNCT
eurjchem-2455	261	4	120	120	NUM
eurjchem-2455	261	5	,	,	PUNCT
eurjchem-2455	261	6	3210–3210	3210–3210	NUM
eurjchem-2455	261	7	.	.	PUNCT
eurjchem-2455	262	1	[	[	X
eurjchem-2455	262	2	20	20	NUM
eurjchem-2455	262	3	]	]	PUNCT
eurjchem-2455	262	4	.	.	PUNCT
eurjchem-2455	262	5	frisch	frisch	PROPN
eurjchem-2455	262	6	,	,	PUNCT
eurjchem-2455	262	7	m.	m.	NOUN
eurjchem-2455	262	8	j.	j.	PROPN
eurjchem-2455	262	9	;	;	PUNCT
eurjchem-2455	262	10	trucks	truck	NOUN
eurjchem-2455	262	11	,	,	PUNCT
eurjchem-2455	262	12	g.	g.	PROPN
eurjchem-2455	262	13	w.	w.	PROPN
eurjchem-2455	262	14	;	;	PUNCT
eurjchem-2455	262	15	schlegel	schlegel	PROPN
eurjchem-2455	262	16	,	,	PUNCT
eurjchem-2455	262	17	h.	h.	PROPN
eurjchem-2455	262	18	b.	b.	PROPN
eurjchem-2455	262	19	;	;	PUNCT
eurjchem-2455	262	20	scuseria	scuseria	PROPN
eurjchem-2455	262	21	,	,	PUNCT
eurjchem-2455	262	22	g.	g.	PROPN
eurjchem-2455	262	23	e.	e.	PROPN
eurjchem-2455	262	24	;	;	PUNCT
eurjchem-2455	262	25	robb	robb	NOUN
eurjchem-2455	262	26	,	,	PUNCT
eurjchem-2455	262	27	m.	m.	NOUN
eurjchem-2455	262	28	a.	a.	PROPN
eurjchem-2455	262	29	;	;	PUNCT
eurjchem-2455	262	30	cheeseman	cheeseman	PROPN
eurjchem-2455	262	31	,	,	PUNCT
eurjchem-2455	262	32	j.	j.	PROPN
eurjchem-2455	262	33	r.	r.	PROPN
eurjchem-2455	262	34	;	;	PUNCT
eurjchem-2455	262	35	montgomery	montgomery	PROPN
eurjchem-2455	262	36	,	,	PUNCT
eurjchem-2455	262	37	j.	j.	PROPN
eurjchem-2455	262	38	a.	a.	PROPN
eurjchem-2455	262	39	;	;	PUNCT
eurjchem-2455	262	40	vreven	vreven	VERB
eurjchem-2455	262	41	,	,	PUNCT
eurjchem-2455	262	42	t.	t.	PROPN
eurjchem-2455	262	43	;	;	PUNCT
eurjchem-2455	262	44	kudin	kudin	PROPN
eurjchem-2455	262	45	,	,	PUNCT
eurjchem-2455	262	46	k.	k.	PROPN
eurjchem-2455	262	47	n.	n.	PROPN
eurjchem-2455	262	48	;	;	PUNCT
eurjchem-2455	262	49	burant	burant	PROPN
eurjchem-2455	262	50	,	,	PUNCT
eurjchem-2455	262	51	j.	j.	PROPN
eurjchem-2455	262	52	c.	c.	PROPN
eurjchem-2455	262	53	;	;	PUNCT
eurjchem-2455	262	54	millam	millam	PROPN
eurjchem-2455	262	55	,	,	PUNCT
eurjchem-2455	262	56	j.	j.	PROPN
eurjchem-2455	262	57	m.	m.	PROPN
eurjchem-2455	262	58	;	;	PUNCT
eurjchem-2455	262	59	iyengar	iyengar	PROPN
eurjchem-2455	262	60	,	,	PUNCT
eurjchem-2455	262	61	s.	s.	PROPN
eurjchem-2455	262	62	s.	s.	PROPN
eurjchem-2455	262	63	;	;	PUNCT
eurjchem-2455	262	64	tomasi	tomasi	PROPN
eurjchem-2455	262	65	,	,	PUNCT
eurjchem-2455	262	66	j.	j.	PROPN
eurjchem-2455	262	67	;	;	PUNCT
eurjchem-2455	262	68	barone	barone	PROPN
eurjchem-2455	262	69	,	,	PUNCT
eurjchem-2455	262	70	v.	v.	PROPN
eurjchem-2455	262	71	;	;	PUNCT
eurjchem-2455	262	72	mennucci	mennucci	PROPN
eurjchem-2455	262	73	,	,	PUNCT
eurjchem-2455	262	74	b.	b.	PROPN
eurjchem-2455	262	75	;	;	PUNCT
eurjchem-2455	262	76	cossi	cossi	PROPN
eurjchem-2455	262	77	,	,	PUNCT
eurjchem-2455	262	78	m.	m.	NOUN
eurjchem-2455	262	79	;	;	PUNCT
eurjchem-2455	262	80	scalmani	scalmani	PROPN
eurjchem-2455	262	81	,	,	PUNCT
eurjchem-2455	262	82	g.	g.	PROPN
eurjchem-2455	262	83	;	;	PUNCT
eurjchem-2455	262	84	rega	rega	PROPN
eurjchem-2455	262	85	,	,	PUNCT
eurjchem-2455	262	86	n.	n.	NOUN
eurjchem-2455	262	87	;	;	PUNCT
eurjchem-2455	262	88	petersson	petersson	PROPN
eurjchem-2455	262	89	,	,	PUNCT
eurjchem-2455	262	90	g.	g.	PROPN
eurjchem-2455	262	91	a.	a.	PROPN
eurjchem-2455	262	92	;	;	PUNCT
eurjchem-2455	262	93	nakatsuji	nakatsuji	PROPN
eurjchem-2455	262	94	,	,	PUNCT
eurjchem-2455	262	95	h.	h.	PROPN
eurjchem-2455	262	96	;	;	PUNCT
eurjchem-2455	262	97	hada	hada	PROPN
eurjchem-2455	262	98	,	,	PUNCT
eurjchem-2455	262	99	m.	m.	NOUN
eurjchem-2455	262	100	;	;	PUNCT
eurjchem-2455	262	101	ehara	ehara	PROPN
eurjchem-2455	262	102	,	,	PUNCT
eurjchem-2455	262	103	m.	m.	NOUN
eurjchem-2455	262	104	;	;	PUNCT
eurjchem-2455	262	105	toyota	toyota	PROPN
eurjchem-2455	262	106	,	,	PUNCT
eurjchem-2455	262	107	k.	k.	PROPN
eurjchem-2455	262	108	;	;	PUNCT
eurjchem-2455	262	109	fukuda	fukuda	PROPN
eurjchem-2455	262	110	,	,	PUNCT
eurjchem-2455	262	111	r.	r.	PROPN
eurjchem-2455	262	112	;	;	PUNCT
eurjchem-2455	262	113	hasegawa	hasegawa	PROPN
eurjchem-2455	262	114	,	,	PUNCT
eurjchem-2455	262	115	j.	j.	PROPN
eurjchem-2455	262	116	;	;	PUNCT
eurjchem-2455	262	117	ishida	ishida	PROPN
eurjchem-2455	262	118	,	,	PUNCT
eurjchem-2455	262	119	m.	m.	NOUN
eurjchem-2455	262	120	;	;	PUNCT
eurjchem-2455	262	121	nakajima	nakajima	PROPN
eurjchem-2455	262	122	,	,	PUNCT
eurjchem-2455	262	123	t.	t.	PROPN
eurjchem-2455	262	124	;	;	PUNCT
eurjchem-2455	262	125	honda	honda	NOUN
eurjchem-2455	262	126	,	,	PUNCT
eurjchem-2455	262	127	y.	y.	PROPN
eurjchem-2455	262	128	;	;	PUNCT
eurjchem-2455	262	129	kitao	kitao	PROPN
eurjchem-2455	262	130	,	,	PUNCT
eurjchem-2455	262	131	o.	o.	PROPN
eurjchem-2455	262	132	;	;	PUNCT
eurjchem-2455	262	133	nakai	nakai	PROPN
eurjchem-2455	262	134	,	,	PUNCT
eurjchem-2455	262	135	h.	h.	PROPN
eurjchem-2455	262	136	;	;	PUNCT
eurjchem-2455	262	137	klene	klene	PROPN
eurjchem-2455	262	138	,	,	PUNCT
eurjchem-2455	262	139	m.	m.	NOUN
eurjchem-2455	262	140	;	;	PUNCT
eurjchem-2455	262	141	li	li	PROPN
eurjchem-2455	262	142	,	,	PUNCT
eurjchem-2455	262	143	x.	x.	PROPN
eurjchem-2455	262	144	;	;	PUNCT
eurjchem-2455	262	145	knox	knox	PROPN
eurjchem-2455	262	146	,	,	PUNCT
eurjchem-2455	262	147	j.	j.	PROPN
eurjchem-2455	262	148	e.	e.	PROPN
eurjchem-2455	262	149	;	;	PUNCT
eurjchem-2455	262	150	hratchian	hratchian	PROPN
eurjchem-2455	262	151	,	,	PUNCT
eurjchem-2455	262	152	h.	h.	PROPN
eurjchem-2455	262	153	p.	p.	PROPN
eurjchem-2455	262	154	;	;	PUNCT
eurjchem-2455	262	155	cross	cross	PROPN
eurjchem-2455	262	156	,	,	PUNCT
eurjchem-2455	262	157	j.	j.	PROPN
eurjchem-2455	262	158	b.	b.	PROPN
eurjchem-2455	262	159	;	;	PUNCT
eurjchem-2455	262	160	adamo	adamo	PROPN
eurjchem-2455	262	161	,	,	PUNCT
eurjchem-2455	262	162	c.	c.	PROPN
eurjchem-2455	262	163	;	;	PUNCT
eurjchem-2455	262	164	jaramillo	jaramillo	PROPN
eurjchem-2455	262	165	,	,	PUNCT
eurjchem-2455	262	166	j.	j.	PROPN
eurjchem-2455	262	167	;	;	PUNCT
eurjchem-2455	262	168	gomperts	gomperts	PROPN
eurjchem-2455	262	169	,	,	PUNCT
eurjchem-2455	262	170	r.	r.	PROPN
eurjchem-2455	262	171	;	;	PUNCT
eurjchem-2455	262	172	stratmann	stratmann	PROPN
eurjchem-2455	262	173	,	,	PUNCT
eurjchem-2455	262	174	r.	r.	PROPN
eurjchem-2455	262	175	e.	e.	PROPN
eurjchem-2455	262	176	;	;	PUNCT
eurjchem-2455	262	177	yazyev	yazyev	PROPN
eurjchem-2455	262	178	,	,	PUNCT
eurjchem-2455	262	179	o.	o.	PROPN
eurjchem-2455	262	180	;	;	PUNCT
eurjchem-2455	262	181	austin	austin	PROPN
eurjchem-2455	262	182	,	,	PUNCT
eurjchem-2455	262	183	a.	a.	PROPN
eurjchem-2455	262	184	j.	j.	PROPN
eurjchem-2455	262	185	;	;	PUNCT
eurjchem-2455	262	186	cammi	cammi	PROPN
eurjchem-2455	262	187	,	,	PUNCT
eurjchem-2455	262	188	r.	r.	PROPN
eurjchem-2455	262	189	;	;	PUNCT
eurjchem-2455	262	190	pomelli	pomelli	PROPN
eurjchem-2455	262	191	,	,	PUNCT
eurjchem-2455	262	192	c.	c.	NOUN
eurjchem-2455	262	193	;	;	PUNCT
eurjchem-2455	262	194	ochterski	ochterski	PROPN
eurjchem-2455	262	195	,	,	PUNCT
eurjchem-2455	262	196	j.	j.	PROPN
eurjchem-2455	262	197	w.	w.	PROPN
eurjchem-2455	262	198	;	;	PUNCT
eurjchem-2455	262	199	ayala	ayala	PROPN
eurjchem-2455	262	200	,	,	PUNCT
eurjchem-2455	262	201	p.	p.	PROPN
eurjchem-2455	262	202	y.	y.	PROPN
eurjchem-2455	262	203	;	;	PUNCT
eurjchem-2455	262	204	morokuma	morokuma	PROPN
eurjchem-2455	262	205	,	,	PUNCT
eurjchem-2455	262	206	k.	k.	PROPN
eurjchem-2455	262	207	;	;	PUNCT
eurjchem-2455	262	208	voth	voth	PROPN
eurjchem-2455	262	209	,	,	PUNCT
eurjchem-2455	262	210	g.	g.	PROPN
eurjchem-2455	262	211	a.	a.	PROPN
eurjchem-2455	262	212	;	;	PUNCT
eurjchem-2455	262	213	salvador	salvador	PROPN
eurjchem-2455	262	214	,	,	PUNCT
eurjchem-2455	262	215	p.	p.	PROPN
eurjchem-2455	262	216	;	;	PUNCT
eurjchem-2455	262	217	dannenberg	dannenberg	PROPN
eurjchem-2455	262	218	,	,	PUNCT
eurjchem-2455	262	219	j.	j.	PROPN
eurjchem-2455	262	220	j.	j.	PROPN
eurjchem-2455	262	221	;	;	PUNCT
eurjchem-2455	262	222	zakrzewski	zakrzewski	PROPN
eurjchem-2455	262	223	,	,	PUNCT
eurjchem-2455	262	224	v.	v.	PROPN
eurjchem-2455	262	225	g.	g.	PROPN
eurjchem-2455	262	226	;	;	PUNCT
eurjchem-2455	262	227	dapprich	dapprich	PROPN
eurjchem-2455	262	228	,	,	PUNCT
eurjchem-2455	262	229	s.	s.	PROPN
eurjchem-2455	262	230	;	;	PUNCT
eurjchem-2455	262	231	daniels	daniels	PROPN
eurjchem-2455	262	232	,	,	PUNCT
eurjchem-2455	262	233	a.	a.	PROPN
eurjchem-2455	262	234	d.	d.	PROPN
eurjchem-2455	262	235	;	;	PUNCT
eurjchem-2455	262	236	strain	strain	NOUN
eurjchem-2455	262	237	,	,	PUNCT
eurjchem-2455	262	238	m.	m.	NOUN
eurjchem-2455	262	239	c.	c.	PROPN
eurjchem-2455	262	240	;	;	PUNCT
eurjchem-2455	262	241	farkas	farkas	PROPN
eurjchem-2455	262	242	,	,	PUNCT
eurjchem-2455	262	243	o.	o.	PROPN
eurjchem-2455	262	244	;	;	PUNCT
eurjchem-2455	262	245	malick	malick	PROPN
eurjchem-2455	262	246	,	,	PUNCT
eurjchem-2455	262	247	d.	d.	PROPN
eurjchem-2455	262	248	k.	k.	PROPN
eurjchem-2455	262	249	;	;	PUNCT
eurjchem-2455	262	250	rabuck	rabuck	VERB
eurjchem-2455	262	251	,	,	PUNCT
eurjchem-2455	262	252	a.	a.	PROPN
eurjchem-2455	262	253	d.	d.	PROPN
eurjchem-2455	262	254	;	;	PUNCT
eurjchem-2455	262	255	raghavachari	raghavachari	PROPN
eurjchem-2455	262	256	,	,	PUNCT
eurjchem-2455	262	257	k	k	PROPN
eurjchem-2455	262	258	;	;	PUNCT
eurjchem-2455	262	259	foresman	foresman	PROPN
eurjchem-2455	262	260	,	,	PUNCT
eurjchem-2455	262	261	j.	j.	PROPN
eurjchem-2455	262	262	b.	b.	PROPN
eurjchem-2455	262	263	;	;	PUNCT
eurjchem-2455	262	264	ortiz	ortiz	PROPN
eurjchem-2455	262	265	,	,	PUNCT
eurjchem-2455	262	266	j.	j.	PROPN
eurjchem-2455	262	267	v.	v.	PROPN
eurjchem-2455	262	268	;	;	PUNCT
eurjchem-2455	262	269	cui	cui	PROPN
eurjchem-2455	262	270	,	,	PUNCT
eurjchem-2455	262	271	q.	q.	PROPN
eurjchem-2455	262	272	;	;	PUNCT
eurjchem-2455	262	273	baboul	baboul	ADJ
eurjchem-2455	262	274	,	,	PUNCT
eurjchem-2455	262	275	a.	a.	NOUN
eurjchem-2455	262	276	g.	g.	PROPN
eurjchem-2455	262	277	;	;	PUNCT
eurjchem-2455	262	278	clifford	clifford	PROPN
eurjchem-2455	262	279	,	,	PUNCT
eurjchem-2455	262	280	s.	s.	PROPN
eurjchem-2455	262	281	;	;	PUNCT
eurjchem-2455	262	282	cioslowski	cioslowski	PROPN
eurjchem-2455	262	283	,	,	PUNCT
eurjchem-2455	262	284	j.	j.	PROPN
eurjchem-2455	262	285	;	;	PUNCT
eurjchem-2455	262	286	stefanov	stefanov	PROPN
eurjchem-2455	262	287	,	,	PUNCT
eurjchem-2455	262	288	b.	b.	PROPN
eurjchem-2455	262	289	b.	b.	PROPN
eurjchem-2455	262	290	;	;	PUNCT
eurjchem-2455	263	1	liu	liu	PROPN
eurjchem-2455	263	2	,	,	PUNCT
eurjchem-2455	263	3	g.	g.	PROPN
eurjchem-2455	263	4	;	;	PUNCT
eurjchem-2455	263	5	liashenko	liashenko	PROPN
eurjchem-2455	263	6	,	,	PUNCT
eurjchem-2455	263	7	a.	a.	NOUN
eurjchem-2455	263	8	;	;	PUNCT
eurjchem-2455	263	9	piskorz	piskorz	PROPN
eurjchem-2455	263	10	,	,	PUNCT
eurjchem-2455	263	11	p.	p.	NOUN
eurjchem-2455	263	12	;	;	PUNCT
eurjchem-2455	263	13	komaromi	komaromi	NOUN
eurjchem-2455	263	14	,	,	PUNCT
eurjchem-2455	263	15	i.	i.	NOUN
eurjchem-2455	263	16	;	;	PUNCT
eurjchem-2455	263	17	martin	martin	PROPN
eurjchem-2455	263	18	,	,	PUNCT
eurjchem-2455	263	19	r.	r.	PROPN
eurjchem-2455	263	20	l.	l.	PROPN
eurjchem-2455	263	21	;	;	PUNCT
eurjchem-2455	263	22	fox	fox	PROPN
eurjchem-2455	263	23	,	,	PUNCT
eurjchem-2455	263	24	d.	d.	PROPN
eurjchem-2455	263	25	j.	j.	PROPN
eurjchem-2455	263	26	;	;	PUNCT
eurjchem-2455	263	27	keith	keith	PROPN
eurjchem-2455	263	28	,	,	PUNCT
eurjchem-2455	263	29	t.	t.	PROPN
eurjchem-2455	263	30	;	;	PUNCT
eurjchem-2455	263	31	al	al	PROPN
eurjchem-2455	263	32	-	-	PUNCT
eurjchem-2455	263	33	laham	laham	PROPN
eurjchem-2455	263	34	,	,	PUNCT
eurjchem-2455	263	35	m.	m.	NOUN
eurjchem-2455	263	36	a.	a.	PROPN
eurjchem-2455	263	37	;	;	PUNCT
eurjchem-2455	263	38	peng	peng	PROPN
eurjchem-2455	263	39	,	,	PUNCT
eurjchem-2455	263	40	c.	c.	PROPN
eurjchem-2455	263	41	y.	y.	PROPN
eurjchem-2455	263	42	;	;	PUNCT
eurjchem-2455	263	43	nanayakkara	nanayakkara	PROPN
eurjchem-2455	263	44	,	,	PUNCT
eurjchem-2455	263	45	a.	a.	NOUN
eurjchem-2455	263	46	;	;	PUNCT
eurjchem-2455	263	47	challacombe	challacombe	ADJ
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eurjchem-2455	263	49	m.	m.	NOUN
eurjchem-2455	263	50	;	;	PUNCT
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eurjchem-2455	263	54	m.	m.	PROPN
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eurjchem-2455	263	58	,	,	PUNCT
eurjchem-2455	263	59	b.	b.	PROPN
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eurjchem-2455	263	66	,	,	PUNCT
eurjchem-2455	263	67	m.	m.	PROPN
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eurjchem-2455	263	71	,	,	PUNCT
eurjchem-2455	263	72	c.	c.	PROPN
eurjchem-2455	263	73	;	;	PUNCT
eurjchem-2455	263	74	pople	pople	PROPN
eurjchem-2455	263	75	,	,	PUNCT
eurjchem-2455	263	76	j.	j.	PROPN
eurjchem-2455	263	77	a.	a.	PROPN
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eurjchem-2455	263	80	,	,	PUNCT
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eurjchem-2455	263	82	inc	inc	PROPN
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eurjchem-2455	263	84	,	,	PUNCT
eurjchem-2455	263	85	wallingford	wallingford	PROPN
eurjchem-2455	263	86	ct	ct	PROPN
eurjchem-2455	263	87	,	,	PUNCT
eurjchem-2455	263	88	2004	2004	NUM
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eurjchem-2455	264	1	[	[	X
eurjchem-2455	264	2	21	21	NUM
eurjchem-2455	264	3	]	]	PUNCT
eurjchem-2455	264	4	.	.	PUNCT
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eurjchem-2455	265	2	,	,	PUNCT
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eurjchem-2455	265	4	;	;	PUNCT
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eurjchem-2455	265	6	,	,	PUNCT
eurjchem-2455	265	7	t.	t.	PROPN
eurjchem-2455	265	8	a.	a.	NOUN
eurjchem-2455	265	9	;	;	PUNCT
eurjchem-2455	265	10	millam	millam	PROPN
eurjchem-2455	265	11	,	,	PUNCT
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eurjchem-2455	265	13	m.	m.	PROPN
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eurjchem-2455	265	15	,	,	PUNCT
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eurjchem-2455	265	18	,	,	PUNCT
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eurjchem-2455	265	21	.	.	PROPN
eurjchem-2455	265	22	;	;	PUNCT
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eurjchem-2455	265	25	,	,	PUNCT
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eurjchem-2455	265	27	,	,	PUNCT
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eurjchem-2455	266	1	[	[	X
eurjchem-2455	266	2	22	22	NUM
eurjchem-2455	266	3	]	]	PUNCT
eurjchem-2455	266	4	.	.	PUNCT
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eurjchem-2455	267	4	,	,	PUNCT
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eurjchem-2455	267	10	;	;	PUNCT
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eurjchem-2455	267	12	ds	ds	ADJ
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eurjchem-2455	267	14	,	,	PUNCT
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eurjchem-2455	267	17	,	,	PUNCT
eurjchem-2455	267	18	san	san	PROPN
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eurjchem-2455	267	20	:	:	PUNCT
eurjchem-2455	267	21	dassault	dassault	NOUN
eurjchem-2455	267	22	systѐmes	systѐme	NOUN
eurjchem-2455	267	23	,	,	PUNCT
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eurjchem-2455	267	25	.	.	PUNCT
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eurjchem-2455	268	5	-	-	SYM
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eurjchem-2455	268	7	-	-	PUNCT
eurjchem-2455	268	8	10	10	NUM
eurjchem-2455	268	9	)	)	PUNCT
eurjchem-2455	268	10	.	.	PUNCT
eurjchem-2455	269	1	[	[	X
eurjchem-2455	269	2	23	23	NUM
eurjchem-2455	269	3	]	]	PUNCT
eurjchem-2455	269	4	.	.	PUNCT
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eurjchem-2455	269	6	,	,	PUNCT
eurjchem-2455	269	7	k.	k.	PROPN
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eurjchem-2455	269	13	ultra	ultra	ADJ
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eurjchem-2455	269	15	.	.	PUNCT
eurjchem-2455	269	16	j.	j.	PROPN
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eurjchem-2455	269	18	.	.	PUNCT
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eurjchem-2455	270	2	.	.	PUNCT
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eurjchem-2455	271	2	.	.	PUNCT
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eurjchem-2455	272	2	,	,	PUNCT
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eurjchem-2455	272	4	,	,	PUNCT
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eurjchem-2455	272	6	.	.	PUNCT
eurjchem-2455	273	1	[	[	X
eurjchem-2455	273	2	24	24	NUM
eurjchem-2455	273	3	]	]	PUNCT
eurjchem-2455	273	4	.	.	PUNCT
eurjchem-2455	274	1	suhail	suhail	PROPN
eurjchem-2455	274	2	,	,	PUNCT
eurjchem-2455	274	3	m.	m.	NOUN
eurjchem-2455	274	4	;	;	PUNCT
eurjchem-2455	274	5	mukhtar	mukhtar	PROPN
eurjchem-2455	274	6	,	,	PUNCT
eurjchem-2455	274	7	s.	s.	PROPN
eurjchem-2455	274	8	d.	d.	PROPN
eurjchem-2455	274	9	;	;	PUNCT
eurjchem-2455	274	10	ali	ali	PROPN
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eurjchem-2455	274	13	;	;	PUNCT
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eurjchem-2455	274	17	;	;	PUNCT
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eurjchem-2455	274	28	:	:	PUNCT
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eurjchem-2455	274	32	.	.	PUNCT
eurjchem-2455	275	1	eur	eur	PROPN
eurjchem-2455	275	2	.	.	PUNCT
eurjchem-2455	276	1	j.	j.	PROPN
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eurjchem-2455	276	3	.	.	PUNCT
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eurjchem-2455	277	2	,	,	PUNCT
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eurjchem-2455	277	4	,	,	PUNCT
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eurjchem-2455	277	6	.	.	PUNCT
eurjchem-2455	278	1	[	[	X
eurjchem-2455	278	2	25	25	NUM
eurjchem-2455	278	3	]	]	PUNCT
eurjchem-2455	278	4	.	.	PUNCT
eurjchem-2455	279	1	ali	ali	PROPN
eurjchem-2455	279	2	,	,	PUNCT
eurjchem-2455	279	3	i.	i.	PROPN
eurjchem-2455	279	4	;	;	PUNCT
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eurjchem-2455	279	6	,	,	PUNCT
eurjchem-2455	279	7	m.	m.	NOUN
eurjchem-2455	279	8	;	;	PUNCT
eurjchem-2455	279	9	asnin	asnin	ADJ
eurjchem-2455	279	10	,	,	PUNCT
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eurjchem-2455	279	27	,	,	PUNCT
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eurjchem-2455	279	29	,	,	PUNCT
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eurjchem-2455	279	31	.	.	PUNCT
eurjchem-2455	280	1	[	[	X
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eurjchem-2455	280	3	]	]	PUNCT
eurjchem-2455	280	4	.	.	PUNCT
eurjchem-2455	281	1	ali	ali	PROPN
eurjchem-2455	281	2	,	,	PUNCT
eurjchem-2455	281	3	i.	i.	PROPN
eurjchem-2455	281	4	;	;	PUNCT
eurjchem-2455	281	5	suhail	suhail	NOUN
eurjchem-2455	281	6	,	,	PUNCT
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eurjchem-2455	281	8	;	;	PUNCT
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eurjchem-2455	281	13	;	;	PUNCT
eurjchem-2455	281	14	al	al	PROPN
eurjchem-2455	281	15	-	-	PUNCT
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eurjchem-2455	281	17	,	,	PUNCT
eurjchem-2455	281	18	a.	a.	NOUN
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eurjchem-2455	282	2	.	.	PUNCT
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eurjchem-2455	283	2	.	.	PUNCT
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eurjchem-2455	284	2	.	.	PUNCT
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eurjchem-2455	284	4	,	,	PUNCT
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eurjchem-2455	284	8	.	.	PUNCT
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eurjchem-2455	285	3	]	]	PUNCT
eurjchem-2455	285	4	.	.	PUNCT
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eurjchem-2455	286	3	z.	z.	PROPN
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eurjchem-2455	286	5	;	;	PUNCT
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eurjchem-2455	286	9	g.	g.	PROPN
eurjchem-2455	286	10	;	;	PUNCT
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eurjchem-2455	286	12	,	,	PUNCT
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eurjchem-2455	286	14	;	;	PUNCT
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eurjchem-2455	286	17	i.	i.	PROPN
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eurjchem-2455	286	29	.	.	PROPN
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eurjchem-2455	286	32	.	.	PUNCT
eurjchem-2455	287	1	b	b	PROPN
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eurjchem-2455	287	3	.	.	PUNCT
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eurjchem-2455	290	3	]	]	PUNCT
eurjchem-2455	290	4	.	.	PUNCT
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eurjchem-2455	291	2	,	,	PUNCT
eurjchem-2455	291	3	z.	z.	PROPN
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eurjchem-2455	291	5	;	;	PUNCT
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eurjchem-2455	291	7	,	,	PUNCT
eurjchem-2455	291	8	a.	a.	NOUN
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eurjchem-2455	291	10	;	;	PUNCT
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eurjchem-2455	291	13	k.	k.	PROPN
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eurjchem-2455	291	15	;	;	PUNCT
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eurjchem-2455	294	4	.	.	PUNCT
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eurjchem-2455	295	3	.	.	PROPN
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eurjchem-2455	295	7	,	,	PUNCT
eurjchem-2455	295	8	122550	122550	NUM
eurjchem-2455	295	9	.	.	PUNCT
eurjchem-2455	296	1	[	[	X
eurjchem-2455	296	2	29	29	NUM
eurjchem-2455	296	3	]	]	PUNCT
eurjchem-2455	296	4	.	.	PUNCT
eurjchem-2455	297	1	suhail	suhail	NOUN
eurjchem-2455	297	2	,	,	PUNCT
eurjchem-2455	297	3	m.	m.	NOUN
eurjchem-2455	297	4	in	in	ADP
eurjchem-2455	297	5	vitro	vitro	X
eurjchem-2455	297	6	anticancer	anticancer	NOUN
eurjchem-2455	297	7	,	,	PUNCT
eurjchem-2455	297	8	antioxidant	antioxidant	ADJ
eurjchem-2455	297	9	and	and	CCONJ
eurjchem-2455	297	10	dna	dna	NOUN
eurjchem-2455	297	11	-	-	PUNCT
eurjchem-2455	297	12	binding	bind	VERB
eurjchem-2455	297	13	study	study	NOUN
eurjchem-2455	297	14	of	of	ADP
eurjchem-2455	297	15	the	the	DET
eurjchem-2455	297	16	bioactive	bioactive	ADJ
eurjchem-2455	297	17	ingredient	ingredient	NOUN
eurjchem-2455	297	18	of	of	ADP
eurjchem-2455	297	19	clove	clove	NOUN
eurjchem-2455	297	20	and	and	CCONJ
eurjchem-2455	297	21	its	its	PRON
eurjchem-2455	297	22	isolation	isolation	NOUN
eurjchem-2455	297	23	.	.	PUNCT
eurjchem-2455	298	1	eur	eur	PROPN
eurjchem-2455	298	2	.	.	PUNCT
eurjchem-2455	299	1	j.	j.	PROPN
eurjchem-2455	299	2	chem	chem	PROPN
eurjchem-2455	299	3	.	.	PUNCT
eurjchem-2455	300	1	2022	2022	NUM
eurjchem-2455	300	2	,	,	PUNCT
eurjchem-2455	300	3	13	13	NUM
eurjchem-2455	300	4	,	,	PUNCT
eurjchem-2455	300	5	33–40	33–40	NUM
eurjchem-2455	300	6	.	.	PUNCT
eurjchem-2455	301	1	[	[	X
eurjchem-2455	301	2	30	30	NUM
eurjchem-2455	301	3	]	]	PUNCT
eurjchem-2455	301	4	.	.	PUNCT
eurjchem-2455	302	1	suhail	suhail	PROPN
eurjchem-2455	302	2	,	,	PUNCT
eurjchem-2455	302	3	m.	m.	NOUN
eurjchem-2455	302	4	;	;	PUNCT
eurjchem-2455	302	5	ali	ali	PROPN
eurjchem-2455	302	6	,	,	PUNCT
eurjchem-2455	302	7	i.	i.	PROPN
eurjchem-2455	302	8	an	an	DET
eurjchem-2455	302	9	advanced	advanced	ADJ
eurjchem-2455	302	10	computational	computational	ADJ
eurjchem-2455	302	11	evaluation	evaluation	NOUN
eurjchem-2455	302	12	for	for	ADP
eurjchem-2455	302	13	the	the	DET
eurjchem-2455	302	14	most	most	ADV
eurjchem-2455	302	15	biologically	biologically	ADV
eurjchem-2455	302	16	active	active	ADJ
eurjchem-2455	302	17	enantiomers	enantiomer	NOUN
eurjchem-2455	302	18	of	of	ADP
eurjchem-2455	302	19	chiral	chiral	ADJ
eurjchem-2455	302	20	anti	anti	ADJ
eurjchem-2455	302	21	-	-	ADJ
eurjchem-2455	302	22	cancer	cancer	ADJ
eurjchem-2455	302	23	agents	agent	NOUN
eurjchem-2455	302	24	.	.	PUNCT
eurjchem-2455	303	1	anticancer	anticancer	NOUN
eurjchem-2455	303	2	agents	agent	NOUN
eurjchem-2455	303	3	med	me	VERB
eurjchem-2455	303	4	.	.	PUNCT
eurjchem-2455	303	5	chem	chem	PROPN
eurjchem-2455	303	6	.	.	PUNCT
eurjchem-2455	304	1	2021	2021	NUM
eurjchem-2455	304	2	,	,	PUNCT
eurjchem-2455	304	3	21	21	NUM
eurjchem-2455	304	4	,	,	PUNCT
eurjchem-2455	304	5	2075–2081	2075–2081	NUM
eurjchem-2455	304	6	.	.	PUNCT
eurjchem-2455	305	1	[	[	X
eurjchem-2455	305	2	31	31	NUM
eurjchem-2455	305	3	]	]	PUNCT
eurjchem-2455	305	4	.	.	PUNCT
eurjchem-2455	306	1	suhail	suhail	PROPN
eurjchem-2455	306	2	,	,	PUNCT
eurjchem-2455	306	3	m.	m.	NOUN
eurjchem-2455	306	4	a	a	DET
eurjchem-2455	306	5	computational	computational	ADJ
eurjchem-2455	306	6	and	and	CCONJ
eurjchem-2455	306	7	literature	literature	NOUN
eurjchem-2455	306	8	-	-	PUNCT
eurjchem-2455	306	9	based	base	VERB
eurjchem-2455	306	10	evaluation	evaluation	NOUN
eurjchem-2455	306	11	for	for	ADP
eurjchem-2455	306	12	a	a	DET
eurjchem-2455	306	13	combination	combination	NOUN
eurjchem-2455	306	14	of	of	ADP
eurjchem-2455	306	15	chiral	chiral	ADJ
eurjchem-2455	306	16	anti	anti	ADJ
eurjchem-2455	306	17	-	-	ADJ
eurjchem-2455	306	18	cov	cov	ADJ
eurjchem-2455	306	19	drugs	drug	NOUN
eurjchem-2455	306	20	to	to	PART
eurjchem-2455	306	21	block	block	VERB
eurjchem-2455	306	22	and	and	CCONJ
eurjchem-2455	306	23	eliminate	eliminate	VERB
eurjchem-2455	306	24	sarscov-2	sarscov-2	NUM
eurjchem-2455	306	25	safely	safely	ADV
eurjchem-2455	306	26	.	.	PUNCT
eurjchem-2455	307	1	j.	j.	PROPN
eurjchem-2455	307	2	comput	comput	PROPN
eurjchem-2455	307	3	.	.	PUNCT
eurjchem-2455	308	1	biophys	biophy	NOUN
eurjchem-2455	308	2	.	.	PUNCT
eurjchem-2455	309	1	chem	chem	NOUN
eurjchem-2455	309	2	.	.	PUNCT
eurjchem-2455	310	1	2021	2021	NUM
eurjchem-2455	310	2	,	,	PUNCT
eurjchem-2455	310	3	20	20	NUM
eurjchem-2455	310	4	,	,	PUNCT
eurjchem-2455	310	5	417–432	417–432	NUM
eurjchem-2455	310	6	.	.	PUNCT
eurjchem-2455	311	1	[	[	X
eurjchem-2455	311	2	32	32	NUM
eurjchem-2455	311	3	]	]	PUNCT
eurjchem-2455	311	4	.	.	PUNCT
eurjchem-2455	312	1	suhail	suhail	PROPN
eurjchem-2455	312	2	,	,	PUNCT
eurjchem-2455	312	3	m.	m.	NOUN
eurjchem-2455	312	4	the	the	DET
eurjchem-2455	312	5	target	target	NOUN
eurjchem-2455	312	6	determination	determination	NOUN
eurjchem-2455	312	7	and	and	CCONJ
eurjchem-2455	312	8	the	the	DET
eurjchem-2455	312	9	mechanism	mechanism	NOUN
eurjchem-2455	312	10	of	of	ADP
eurjchem-2455	312	11	action	action	NOUN
eurjchem-2455	312	12	of	of	ADP
eurjchem-2455	312	13	chiral	chiral	ADJ
eurjchem-2455	312	14	-	-	PUNCT
eurjchem-2455	312	15	antimalarial	antimalarial	ADJ
eurjchem-2455	312	16	drugs	drug	NOUN
eurjchem-2455	312	17	:	:	PUNCT
eurjchem-2455	312	18	a	a	DET
eurjchem-2455	312	19	docking	docking	NOUN
eurjchem-2455	312	20	approach	approach	NOUN
eurjchem-2455	312	21	.	.	PUNCT
eurjchem-2455	313	1	j.	j.	PROPN
eurjchem-2455	313	2	comput	comput	PROPN
eurjchem-2455	313	3	.	.	PUNCT
eurjchem-2455	314	1	biophys	biophy	NOUN
eurjchem-2455	314	2	.	.	PUNCT
eurjchem-2455	315	1	chem	chem	NOUN
eurjchem-2455	315	2	.	.	PUNCT
eurjchem-2455	316	1	2021	2021	NUM
eurjchem-2455	316	2	,	,	PUNCT
eurjchem-2455	316	3	20	20	NUM
eurjchem-2455	316	4	,	,	PUNCT
eurjchem-2455	316	5	501–516	501–516	NUM
eurjchem-2455	316	6	.	.	PUNCT
eurjchem-2455	317	1	[	[	X
eurjchem-2455	317	2	33	33	NUM
eurjchem-2455	317	3	]	]	PUNCT
eurjchem-2455	317	4	.	.	PUNCT
eurjchem-2455	318	1	suhail	suhail	PROPN
eurjchem-2455	318	2	,	,	PUNCT
eurjchem-2455	318	3	m.	m.	NOUN
eurjchem-2455	318	4	the	the	DET
eurjchem-2455	318	5	mystery	mystery	NOUN
eurjchem-2455	318	6	of	of	ADP
eurjchem-2455	318	7	chemistry	chemistry	NOUN
eurjchem-2455	318	8	behind	behind	ADP
eurjchem-2455	318	9	the	the	DET
eurjchem-2455	318	10	mechanism	mechanism	NOUN
eurjchem-2455	318	11	of	of	ADP
eurjchem-2455	318	12	action	action	NOUN
eurjchem-2455	318	13	of	of	ADP
eurjchem-2455	318	14	anti	anti	ADJ
eurjchem-2455	318	15	-	-	ADJ
eurjchem-2455	318	16	hiv	hiv	ADJ
eurjchem-2455	318	17	drugs	drug	NOUN
eurjchem-2455	318	18	:	:	PUNCT
eurjchem-2455	318	19	a	a	DET
eurjchem-2455	318	20	docking	docking	NOUN
eurjchem-2455	318	21	approach	approach	NOUN
eurjchem-2455	318	22	at	at	ADP
eurjchem-2455	318	23	an	an	DET
eurjchem-2455	318	24	atomic	atomic	ADJ
eurjchem-2455	318	25	level	level	NOUN
eurjchem-2455	318	26	.	.	PUNCT
eurjchem-2455	319	1	eur	eur	PROPN
eurjchem-2455	319	2	.	.	PUNCT
eurjchem-2455	320	1	j.	j.	PROPN
eurjchem-2455	320	2	chem	chem	PROPN
eurjchem-2455	320	3	.	.	PUNCT
eurjchem-2455	321	1	2021	2021	NUM
eurjchem-2455	321	2	,	,	PUNCT
eurjchem-2455	321	3	12	12	NUM
eurjchem-2455	321	4	,	,	PUNCT
eurjchem-2455	321	5	432–438	432–438	NUM
eurjchem-2455	321	6	.	.	PUNCT
eurjchem-2455	322	1	[	[	X
eurjchem-2455	322	2	34	34	NUM
eurjchem-2455	322	3	]	]	SYM
eurjchem-2455	322	4	.	.	PUNCT
eurjchem-2455	322	5	rengasamy	rengasamy	NOUN
eurjchem-2455	322	6	,	,	PUNCT
eurjchem-2455	322	7	v.	v.	PROPN
eurjchem-2455	322	8	;	;	PUNCT
eurjchem-2455	322	9	suhail	suhail	NOUN
eurjchem-2455	322	10	,	,	PUNCT
eurjchem-2455	322	11	m.	m.	NOUN
eurjchem-2455	322	12	;	;	PUNCT
eurjchem-2455	322	13	jain	jain	PROPN
eurjchem-2455	322	14	,	,	PUNCT
eurjchem-2455	322	15	a.	a.	NOUN
eurjchem-2455	322	16	green	green	ADJ
eurjchem-2455	322	17	synthesis	synthesis	NOUN
eurjchem-2455	322	18	of	of	ADP
eurjchem-2455	322	19	uracil	uracil	ADJ
eurjchem-2455	322	20	derivatives	derivative	NOUN
eurjchem-2455	322	21	,	,	PUNCT
eurjchem-2455	322	22	dna	dna	NOUN
eurjchem-2455	322	23	binding	bind	VERB
eurjchem-2455	322	24	study	study	NOUN
eurjchem-2455	322	25	and	and	CCONJ
eurjchem-2455	322	26	docking	docking	NOUN
eurjchem-2455	322	27	-	-	PUNCT
eurjchem-2455	322	28	based	base	VERB
eurjchem-2455	322	29	evaluation	evaluation	NOUN
eurjchem-2455	322	30	of	of	ADP
eurjchem-2455	322	31	their	their	PRON
eurjchem-2455	322	32	anti	anti	ADJ
eurjchem-2455	322	33	-	-	NOUN
eurjchem-2455	322	34	cancer	cancer	ADJ
eurjchem-2455	322	35	and	and	CCONJ
eurjchem-2455	322	36	anti	anti	ADJ
eurjchem-2455	322	37	-	-	ADJ
eurjchem-2455	322	38	viral	viral	ADJ
eurjchem-2455	322	39	potencies	potency	NOUN
eurjchem-2455	322	40	.	.	PUNCT
eurjchem-2455	323	1	act	act	PROPN
eurjchem-2455	323	2	scie	scie	PROPN
eurjchem-2455	323	3	pharma	pharma	PROPN
eurjchem-2455	323	4	2022	2022	NUM
eurjchem-2455	323	5	,	,	PUNCT
eurjchem-2455	323	6	116–133	116–133	NUM
eurjchem-2455	323	7	.	.	PUNCT
eurjchem-2455	324	1	[	[	X
eurjchem-2455	324	2	35	35	NUM
eurjchem-2455	324	3	]	]	SYM
eurjchem-2455	324	4	.	.	PUNCT
eurjchem-2455	324	5	harrington	harrington	PROPN
eurjchem-2455	324	6	,	,	PUNCT
eurjchem-2455	324	7	d.	d.	PROPN
eurjchem-2455	324	8	j.	j.	PROPN
eurjchem-2455	324	9	;	;	PUNCT
eurjchem-2455	324	10	adachi	adachi	PROPN
eurjchem-2455	324	11	,	,	PUNCT
eurjchem-2455	324	12	k.	k.	PROPN
eurjchem-2455	324	13	;	;	PUNCT
eurjchem-2455	324	14	royer	royer	PROPN
eurjchem-2455	324	15	,	,	PUNCT
eurjchem-2455	324	16	w.	w.	PROPN
eurjchem-2455	324	17	e.	e.	PROPN
eurjchem-2455	324	18	,	,	PUNCT
eurjchem-2455	324	19	jr	jr	PROPN
eurjchem-2455	324	20	the	the	DET
eurjchem-2455	324	21	high	high	ADJ
eurjchem-2455	324	22	resolution	resolution	NOUN
eurjchem-2455	324	23	crystal	crystal	NOUN
eurjchem-2455	324	24	structure	structure	NOUN
eurjchem-2455	324	25	of	of	ADP
eurjchem-2455	324	26	deoxyhemoglobin	deoxyhemoglobin	PROPN
eurjchem-2455	324	27	s.	s.	PROPN
eurjchem-2455	324	28	j.	j.	PROPN
eurjchem-2455	324	29	mol	mol	PROPN
eurjchem-2455	324	30	.	.	PUNCT
eurjchem-2455	324	31	biol	biol	PROPN
eurjchem-2455	324	32	.	.	PUNCT
eurjchem-2455	325	1	1997	1997	NUM
eurjchem-2455	325	2	,	,	PUNCT
eurjchem-2455	325	3	272	272	NUM
eurjchem-2455	325	4	,	,	PUNCT
eurjchem-2455	325	5	398–407	398–407	NUM
eurjchem-2455	325	6	.	.	PUNCT
eurjchem-2455	326	1	[	[	X
eurjchem-2455	326	2	36	36	NUM
eurjchem-2455	326	3	]	]	PUNCT
eurjchem-2455	326	4	.	.	PUNCT
eurjchem-2455	327	1	dapprich	dapprich	PROPN
eurjchem-2455	327	2	,	,	PUNCT
eurjchem-2455	327	3	s.	s.	PROPN
eurjchem-2455	327	4	;	;	PUNCT
eurjchem-2455	327	5	komáromi	komáromi	PROPN
eurjchem-2455	327	6	,	,	PUNCT
eurjchem-2455	327	7	i.	i.	PROPN
eurjchem-2455	327	8	;	;	PUNCT
eurjchem-2455	327	9	byun	byun	NOUN
eurjchem-2455	327	10	,	,	PUNCT
eurjchem-2455	327	11	k.	k.	PROPN
eurjchem-2455	327	12	s.	s.	PROPN
eurjchem-2455	327	13	;	;	PUNCT
eurjchem-2455	327	14	morokuma	morokuma	PROPN
eurjchem-2455	327	15	,	,	PUNCT
eurjchem-2455	327	16	k.	k.	PROPN
eurjchem-2455	327	17	;	;	PUNCT
eurjchem-2455	327	18	frisch	frisch	PROPN
eurjchem-2455	327	19	,	,	PUNCT
eurjchem-2455	327	20	m.	m.	NOUN
eurjchem-2455	327	21	j.	j.	PROPN
eurjchem-2455	328	1	a	a	DET
eurjchem-2455	328	2	new	new	ADJ
eurjchem-2455	328	3	oniom	oniom	NOUN
eurjchem-2455	328	4	implementation	implementation	NOUN
eurjchem-2455	328	5	in	in	ADP
eurjchem-2455	328	6	gaussian98	gaussian98	NOUN
eurjchem-2455	328	7	.	.	PUNCT
eurjchem-2455	329	1	part	part	NOUN
eurjchem-2455	329	2	i.	i.	PROPN
eurjchem-2455	329	3	the	the	DET
eurjchem-2455	329	4	calculation	calculation	NOUN
eurjchem-2455	329	5	of	of	ADP
eurjchem-2455	329	6	energies	energy	NOUN
eurjchem-2455	329	7	,	,	PUNCT
eurjchem-2455	329	8	gradients	gradient	NOUN
eurjchem-2455	329	9	,	,	PUNCT
eurjchem-2455	329	10	vibrational	vibrational	ADJ
eurjchem-2455	329	11	frequencies	frequency	NOUN
eurjchem-2455	329	12	and	and	CCONJ
eurjchem-2455	329	13	electric	electric	ADJ
eurjchem-2455	329	14	field	field	NOUN
eurjchem-2455	329	15	derivatives	derivative	NOUN
eurjchem-2455	329	16	.	.	PUNCT
eurjchem-2455	330	1	theochem	theochem	NOUN
eurjchem-2455	330	2	1999	1999	NUM
eurjchem-2455	330	3	,	,	PUNCT
eurjchem-2455	330	4	461–462	461–462	NUM
eurjchem-2455	330	5	,	,	PUNCT
eurjchem-2455	330	6	1–21	1–21	PROPN
eurjchem-2455	330	7	.	.	PUNCT
eurjchem-2455	331	1	[	[	X
eurjchem-2455	331	2	37	37	NUM
eurjchem-2455	331	3	]	]	PUNCT
eurjchem-2455	331	4	.	.	PUNCT
eurjchem-2455	332	1	čársky	čársky	NOUN
eurjchem-2455	332	2	,	,	PUNCT
eurjchem-2455	332	3	p.	p.	PROPN
eurjchem-2455	332	4	;	;	PUNCT
eurjchem-2455	332	5	hubač	hubač	PROPN
eurjchem-2455	332	6	,	,	PUNCT
eurjchem-2455	332	7	i.	i.	PROPN
eurjchem-2455	332	8	restricted	restrict	VERB
eurjchem-2455	332	9	hartree	hartree	ADV
eurjchem-2455	332	10	-	-	PUNCT
eurjchem-2455	332	11	fock	fock	ADJ
eurjchem-2455	332	12	and	and	CCONJ
eurjchem-2455	332	13	unrestricted	unrestricted	ADJ
eurjchem-2455	332	14	hartreefock	hartreefock	NOUN
eurjchem-2455	332	15	as	as	ADP
eurjchem-2455	332	16	reference	reference	NOUN
eurjchem-2455	332	17	states	state	NOUN
eurjchem-2455	332	18	in	in	ADP
eurjchem-2455	332	19	many	many	ADJ
eurjchem-2455	332	20	-	-	PUNCT
eurjchem-2455	332	21	body	body	NOUN
eurjchem-2455	332	22	perturbation	perturbation	NOUN
eurjchem-2455	332	23	theory	theory	NOUN
eurjchem-2455	332	24	:	:	PUNCT
eurjchem-2455	332	25	a	a	DET
eurjchem-2455	332	26	critical	critical	ADJ
eurjchem-2455	332	27	comparison	comparison	NOUN
eurjchem-2455	332	28	of	of	ADP
eurjchem-2455	332	29	the	the	DET
eurjchem-2455	332	30	two	two	NUM
eurjchem-2455	332	31	approaches	approach	NOUN
eurjchem-2455	332	32	.	.	PUNCT
eurjchem-2455	333	1	theoret	theoret	ADJ
eurjchem-2455	333	2	.	.	PUNCT
eurjchem-2455	334	1	chim	chim	PROPN
eurjchem-2455	334	2	.	.	PUNCT
eurjchem-2455	335	1	acta	acta	PROPN
eurjchem-2455	335	2	1991	1991	NUM
eurjchem-2455	335	3	,	,	PUNCT
eurjchem-2455	335	4	80	80	NUM
eurjchem-2455	335	5	,	,	PUNCT
eurjchem-2455	335	6	407	407	NUM
eurjchem-2455	335	7	–	–	PUNCT
eurjchem-2455	335	8	425	425	NUM
eurjchem-2455	335	9	.	.	PUNCT
eurjchem-2455	336	1	[	[	X
eurjchem-2455	336	2	38	38	NUM
eurjchem-2455	336	3	]	]	PUNCT
eurjchem-2455	336	4	.	.	PUNCT
eurjchem-2455	337	1	becke	becke	NOUN
eurjchem-2455	337	2	,	,	PUNCT
eurjchem-2455	337	3	a.	a.	PROPN
eurjchem-2455	337	4	d.	d.	PROPN
eurjchem-2455	337	5	density	density	PROPN
eurjchem-2455	337	6	-	-	PUNCT
eurjchem-2455	337	7	functional	functional	ADJ
eurjchem-2455	337	8	thermochemistry	thermochemistry	NOUN
eurjchem-2455	337	9	.	.	PUNCT
eurjchem-2455	338	1	iii	iii	X
eurjchem-2455	338	2	.	.	PUNCT
eurjchem-2455	339	1	the	the	DET
eurjchem-2455	339	2	role	role	NOUN
eurjchem-2455	339	3	of	of	ADP
eurjchem-2455	339	4	exact	exact	ADJ
eurjchem-2455	339	5	exchange	exchange	NOUN
eurjchem-2455	339	6	.	.	PUNCT
eurjchem-2455	340	1	j.	j.	PROPN
eurjchem-2455	340	2	chem	chem	PROPN
eurjchem-2455	340	3	.	.	PUNCT
eurjchem-2455	341	1	phys	phy	NOUN
eurjchem-2455	341	2	.	.	PUNCT
eurjchem-2455	342	1	1993	1993	NUM
eurjchem-2455	342	2	,	,	PUNCT
eurjchem-2455	342	3	98	98	NUM
eurjchem-2455	342	4	,	,	PUNCT
eurjchem-2455	342	5	5648–5652	5648–5652	NUM
eurjchem-2455	342	6	.	.	PUNCT
eurjchem-2455	343	1	[	[	X
eurjchem-2455	343	2	39	39	NUM
eurjchem-2455	343	3	]	]	PUNCT
eurjchem-2455	343	4	.	.	PUNCT
eurjchem-2455	344	1	clark	clark	PROPN
eurjchem-2455	344	2	,	,	PUNCT
eurjchem-2455	344	3	t.	t.	PROPN
eurjchem-2455	344	4	;	;	PUNCT
eurjchem-2455	344	5	chandrasekhar	chandrasekhar	PROPN
eurjchem-2455	344	6	,	,	PUNCT
eurjchem-2455	344	7	j.	j.	PROPN
eurjchem-2455	344	8	;	;	PUNCT
eurjchem-2455	344	9	spitznagel	spitznagel	NOUN
eurjchem-2455	344	10	,	,	PUNCT
eurjchem-2455	344	11	g.	g.	PROPN
eurjchem-2455	344	12	w.	w.	PROPN
eurjchem-2455	344	13	;	;	PUNCT
eurjchem-2455	344	14	schleyer	schleyer	PROPN
eurjchem-2455	344	15	,	,	PUNCT
eurjchem-2455	344	16	p.	p.	NOUN
eurjchem-2455	344	17	v.	v.	PROPN
eurjchem-2455	345	1	r.	r.	PROPN
eurjchem-2455	345	2	efficient	efficient	PROPN
eurjchem-2455	345	3	diffuse	diffuse	PROPN
eurjchem-2455	345	4	function	function	NOUN
eurjchem-2455	345	5	-	-	PUNCT
eurjchem-2455	345	6	augmented	augment	VERB
eurjchem-2455	345	7	basis	basis	NOUN
eurjchem-2455	345	8	sets	set	NOUN
eurjchem-2455	345	9	for	for	ADP
eurjchem-2455	345	10	anion	anion	NOUN
eurjchem-2455	345	11	calculations	calculation	NOUN
eurjchem-2455	345	12	.	.	PUNCT
eurjchem-2455	346	1	iii	iii	X
eurjchem-2455	346	2	.	.	PUNCT
eurjchem-2455	347	1	the	the	DET
eurjchem-2455	347	2	3	3	NUM
eurjchem-2455	347	3	-	-	SYM
eurjchem-2455	347	4	21+g	21+g	NUM
eurjchem-2455	347	5	basis	basis	NOUN
eurjchem-2455	347	6	set	set	NOUN
eurjchem-2455	347	7	for	for	ADP
eurjchem-2455	347	8	first	first	ADJ
eurjchem-2455	347	9	-	-	PUNCT
eurjchem-2455	347	10	row	row	NOUN
eurjchem-2455	347	11	elements	element	NOUN
eurjchem-2455	347	12	,	,	PUNCT
eurjchem-2455	347	13	li	li	PROPN
eurjchem-2455	347	14	-	-	PROPN
eurjchem-2455	347	15	f.	f.	PROPN
eurjchem-2455	347	16	j.	j.	PROPN
eurjchem-2455	347	17	comput	comput	PROPN
eurjchem-2455	347	18	.	.	PUNCT
eurjchem-2455	348	1	chem	chem	PROPN
eurjchem-2455	348	2	.	.	PUNCT
eurjchem-2455	349	1	1983	1983	NUM
eurjchem-2455	349	2	,	,	PUNCT
eurjchem-2455	349	3	4	4	NUM
eurjchem-2455	349	4	,	,	PUNCT
eurjchem-2455	349	5	294–301	294–301	NUM
eurjchem-2455	349	6	.	.	PUNCT
eurjchem-2455	350	1	[	[	X
eurjchem-2455	350	2	40	40	NUM
eurjchem-2455	350	3	]	]	PUNCT
eurjchem-2455	350	4	.	.	PUNCT
eurjchem-2455	351	1	berger	berger	PROPN
eurjchem-2455	351	2	,	,	PUNCT
eurjchem-2455	351	3	t.	t.	PROPN
eurjchem-2455	351	4	a.	a.	PROPN
eurjchem-2455	351	5	;	;	PUNCT
eurjchem-2455	351	6	berger	berger	PROPN
eurjchem-2455	351	7	,	,	PUNCT
eurjchem-2455	351	8	b.	b.	PROPN
eurjchem-2455	351	9	k.	k.	PROPN
eurjchem-2455	351	10	;	;	PUNCT
eurjchem-2455	351	11	kogelman	kogelman	PROPN
eurjchem-2455	351	12	,	,	PUNCT
eurjchem-2455	351	13	k.	k.	PROPN
eurjchem-2455	351	14	supercritical	supercritical	ADJ
eurjchem-2455	351	15	fluid	fluid	NOUN
eurjchem-2455	351	16	chromatography	chromatography	NOUN
eurjchem-2455	351	17	for	for	ADP
eurjchem-2455	351	18	chiral	chiral	ADJ
eurjchem-2455	351	19	analysis	analysis	NOUN
eurjchem-2455	351	20	and	and	CCONJ
eurjchem-2455	351	21	semi	semi	ADJ
eurjchem-2455	351	22	-	-	ADJ
eurjchem-2455	351	23	preparative	preparative	ADJ
eurjchem-2455	351	24	purification	purification	NOUN
eurjchem-2455	351	25	.	.	PUNCT
eurjchem-2455	352	1	in	in	ADP
eurjchem-2455	352	2	reference	reference	NOUN
eurjchem-2455	352	3	module	module	NOUN
eurjchem-2455	352	4	in	in	ADP
eurjchem-2455	352	5	chemistry	chemistry	NOUN
eurjchem-2455	352	6	,	,	PUNCT
eurjchem-2455	352	7	molecular	molecular	ADJ
eurjchem-2455	352	8	sciences	science	NOUN
eurjchem-2455	352	9	and	and	CCONJ
eurjchem-2455	352	10	chemical	chemical	PROPN
eurjchem-2455	352	11	engineering	engineering	NOUN
eurjchem-2455	352	12	;	;	PUNCT
eurjchem-2455	352	13	elsevier	elsevier	NOUN
eurjchem-2455	352	14	,	,	PUNCT
eurjchem-2455	352	15	2022	2022	NUM
eurjchem-2455	352	16	.	.	PUNCT
eurjchem-2455	353	1	[	[	X
eurjchem-2455	353	2	41	41	NUM
eurjchem-2455	353	3	]	]	PUNCT
eurjchem-2455	353	4	.	.	PUNCT
eurjchem-2455	354	1	berinde	berinde	PROPN
eurjchem-2455	354	2	,	,	PUNCT
eurjchem-2455	354	3	z.	z.	PROPN
eurjchem-2455	354	4	m.	m.	PROPN
eurjchem-2455	354	5	qspr	qspr	PROPN
eurjchem-2455	354	6	models	model	NOUN
eurjchem-2455	354	7	for	for	ADP
eurjchem-2455	354	8	the	the	DET
eurjchem-2455	354	9	molar	molar	ADJ
eurjchem-2455	354	10	refraction	refraction	NOUN
eurjchem-2455	354	11	,	,	PUNCT
eurjchem-2455	354	12	polarizability	polarizability	NOUN
eurjchem-2455	354	13	and	and	CCONJ
eurjchem-2455	354	14	refractive	refractive	ADJ
eurjchem-2455	354	15	index	index	NOUN
eurjchem-2455	354	16	of	of	ADP
eurjchem-2455	354	17	aliphatic	aliphatic	ADJ
eurjchem-2455	354	18	carboxylic	carboxylic	ADJ
eurjchem-2455	354	19	acids	acid	NOUN
eurjchem-2455	354	20	using	use	VERB
eurjchem-2455	354	21	the	the	DET
eurjchem-2455	354	22	zep	zep	PROPN
eurjchem-2455	354	23	topological	topological	PROPN
eurjchem-2455	354	24	index	index	PROPN
eurjchem-2455	354	25	.	.	PUNCT
eurjchem-2455	355	1	symmetry	symmetry	NOUN
eurjchem-2455	355	2	(	(	PUNCT
eurjchem-2455	355	3	basel	basel	PROPN
eurjchem-2455	355	4	)	)	PUNCT
eurjchem-2455	355	5	2021	2021	NUM
eurjchem-2455	355	6	,	,	PUNCT
eurjchem-2455	355	7	13	13	NUM
eurjchem-2455	355	8	,	,	PUNCT
eurjchem-2455	355	9	2359	2359	NUM
eurjchem-2455	355	10	.	.	PUNCT
eurjchem-2455	356	1	[	[	X
eurjchem-2455	356	2	42	42	NUM
eurjchem-2455	356	3	]	]	PUNCT
eurjchem-2455	356	4	.	.	PUNCT
eurjchem-2455	357	1	huang	huang	PROPN
eurjchem-2455	357	2	,	,	PUNCT
eurjchem-2455	357	3	g.	g.	PROPN
eurjchem-2455	357	4	;	;	PUNCT
eurjchem-2455	357	5	lu	lu	PROPN
eurjchem-2455	357	6	,	,	PUNCT
eurjchem-2455	357	7	c.-h	c.-h	PROPN
eurjchem-2455	357	8	.	.	PUNCT
eurjchem-2455	357	9	;	;	PUNCT
eurjchem-2455	357	10	yang	yang	PROPN
eurjchem-2455	357	11	,	,	PUNCT
eurjchem-2455	357	12	h.-h	h.-h	PROPN
eurjchem-2455	357	13	.	.	PUNCT
eurjchem-2455	358	1	magnetic	magnetic	ADJ
eurjchem-2455	358	2	nanomaterials	nanomaterial	NOUN
eurjchem-2455	358	3	for	for	ADP
eurjchem-2455	358	4	magnetic	magnetic	ADJ
eurjchem-2455	358	5	bioanalysis	bioanalysis	NOUN
eurjchem-2455	358	6	.	.	PUNCT
eurjchem-2455	359	1	in	in	ADP
eurjchem-2455	359	2	novel	novel	ADJ
eurjchem-2455	359	3	nanomaterials	nanomaterial	NOUN
eurjchem-2455	359	4	for	for	ADP
eurjchem-2455	359	5	biomedical	biomedical	ADJ
eurjchem-2455	359	6	,	,	PUNCT
eurjchem-2455	359	7	environmental	environmental	ADJ
eurjchem-2455	359	8	and	and	CCONJ
eurjchem-2455	359	9	energy	energy	NOUN
eurjchem-2455	359	10	applications	application	NOUN
eurjchem-2455	359	11	;	;	PUNCT
eurjchem-2455	359	12	elsevier	elsevier	NOUN
eurjchem-2455	359	13	,	,	PUNCT
eurjchem-2455	359	14	2019	2019	NUM
eurjchem-2455	359	15	;	;	PUNCT
eurjchem-2455	359	16	pp	pp	ADP
eurjchem-2455	359	17	.	.	PUNCT
eurjchem-2455	360	1	89–109	89–109	VERB
eurjchem-2455	360	2	.	.	PUNCT
eurjchem-2455	361	1	[	[	X
eurjchem-2455	361	2	43	43	NUM
eurjchem-2455	361	3	]	]	PUNCT
eurjchem-2455	361	4	.	.	PUNCT
eurjchem-2455	362	1	vistoli	vistoli	PROPN
eurjchem-2455	362	2	,	,	PUNCT
eurjchem-2455	362	3	g.	g.	PROPN
eurjchem-2455	362	4	;	;	PUNCT
eurjchem-2455	362	5	pedretti	pedretti	PROPN
eurjchem-2455	362	6	,	,	PUNCT
eurjchem-2455	362	7	a.	a.	NOUN
eurjchem-2455	362	8	molecular	molecular	ADJ
eurjchem-2455	362	9	fields	field	NOUN
eurjchem-2455	362	10	to	to	PART
eurjchem-2455	362	11	assess	assess	VERB
eurjchem-2455	362	12	recognition	recognition	NOUN
eurjchem-2455	362	13	forces	force	NOUN
eurjchem-2455	362	14	and	and	CCONJ
eurjchem-2455	362	15	property	property	NOUN
eurjchem-2455	362	16	spaces	space	NOUN
eurjchem-2455	362	17	.	.	PUNCT
eurjchem-2455	363	1	in	in	ADP
eurjchem-2455	363	2	comprehensive	comprehensive	ADJ
eurjchem-2455	363	3	medicinal	medicinal	ADJ
eurjchem-2455	363	4	chemistry	chemistry	PROPN
eurjchem-2455	363	5	ii	ii	PROPN
eurjchem-2455	363	6	;	;	PUNCT
eurjchem-2455	363	7	elsevier	elsevier	NOUN
eurjchem-2455	363	8	,	,	PUNCT
eurjchem-2455	363	9	2007	2007	NUM
eurjchem-2455	363	10	;	;	PUNCT
eurjchem-2455	363	11	pp	pp	ADP
eurjchem-2455	363	12	.	.	PUNCT
eurjchem-2455	364	1	577–602	577–602	NUM
eurjchem-2455	364	2	.	.	PUNCT
eurjchem-2455	365	1	[	[	X
eurjchem-2455	365	2	44	44	NUM
eurjchem-2455	365	3	]	]	PUNCT
eurjchem-2455	365	4	.	.	PUNCT
eurjchem-2455	366	1	aihara	aihara	PROPN
eurjchem-2455	366	2	,	,	PUNCT
eurjchem-2455	366	3	j.-i	j.-i	PROPN
eurjchem-2455	366	4	.	.	PUNCT
eurjchem-2455	367	1	reduced	reduce	VERB
eurjchem-2455	367	2	homo−lumo	homo−lumo	PROPN
eurjchem-2455	367	3	gap	gap	NOUN
eurjchem-2455	367	4	as	as	ADP
eurjchem-2455	367	5	an	an	DET
eurjchem-2455	367	6	index	index	NOUN
eurjchem-2455	367	7	of	of	ADP
eurjchem-2455	367	8	kinetic	kinetic	ADJ
eurjchem-2455	367	9	stability	stability	NOUN
eurjchem-2455	367	10	for	for	ADP
eurjchem-2455	367	11	polycyclic	polycyclic	ADJ
eurjchem-2455	367	12	aromatic	aromatic	ADJ
eurjchem-2455	367	13	hydrocarbons	hydrocarbon	NOUN
eurjchem-2455	367	14	.	.	PUNCT
eurjchem-2455	368	1	j.	j.	PROPN
eurjchem-2455	368	2	phys	phys	PROPN
eurjchem-2455	368	3	.	.	PUNCT
eurjchem-2455	369	1	chem	chem	PROPN
eurjchem-2455	369	2	.	.	PUNCT
eurjchem-2455	370	1	a	a	DET
eurjchem-2455	370	2	1999	1999	NUM
eurjchem-2455	370	3	,	,	PUNCT
eurjchem-2455	370	4	103	103	NUM
eurjchem-2455	370	5	,	,	PUNCT
eurjchem-2455	370	6	7487–7495	7487–7495	NUM
eurjchem-2455	370	7	.	.	PUNCT
eurjchem-2455	371	1	[	[	X
eurjchem-2455	371	2	45	45	NUM
eurjchem-2455	371	3	]	]	PUNCT
eurjchem-2455	371	4	.	.	PUNCT
eurjchem-2455	372	1	manolopoulos	manolopoulos	PROPN
eurjchem-2455	372	2	,	,	PUNCT
eurjchem-2455	372	3	d.	d.	PROPN
eurjchem-2455	372	4	e.	e.	PROPN
eurjchem-2455	372	5	;	;	PUNCT
eurjchem-2455	372	6	may	may	PROPN
eurjchem-2455	372	7	,	,	PUNCT
eurjchem-2455	372	8	j.	j.	PROPN
eurjchem-2455	372	9	c.	c.	PROPN
eurjchem-2455	372	10	;	;	PUNCT
eurjchem-2455	372	11	down	down	ADV
eurjchem-2455	372	12	,	,	PUNCT
eurjchem-2455	372	13	s.	s.	PROPN
eurjchem-2455	372	14	e.	e.	PROPN
eurjchem-2455	372	15	theoretical	theoretical	PROPN
eurjchem-2455	372	16	studies	study	NOUN
eurjchem-2455	372	17	of	of	ADP
eurjchem-2455	372	18	the	the	DET
eurjchem-2455	372	19	fullerenes	fullerene	NOUN
eurjchem-2455	372	20	:	:	PUNCT
eurjchem-2455	372	21	c34	c34	NOUN
eurjchem-2455	372	22	to	to	ADP
eurjchem-2455	372	23	c70	c70	PROPN
eurjchem-2455	372	24	.	.	PROPN
eurjchem-2455	372	25	chem	chem	PROPN
eurjchem-2455	372	26	.	.	PUNCT
eurjchem-2455	373	1	phys	phy	NOUN
eurjchem-2455	373	2	.	.	PUNCT
eurjchem-2455	374	1	lett	lett	PROPN
eurjchem-2455	374	2	.	.	PROPN
eurjchem-2455	374	3	1991	1991	NUM
eurjchem-2455	374	4	,	,	PUNCT
eurjchem-2455	374	5	181	181	NUM
eurjchem-2455	374	6	,	,	PUNCT
eurjchem-2455	374	7	105–111	105–111	NUM
eurjchem-2455	374	8	.	.	PUNCT
eurjchem-2455	375	1	[	[	X
eurjchem-2455	375	2	46	46	NUM
eurjchem-2455	375	3	]	]	PUNCT
eurjchem-2455	375	4	.	.	PUNCT
eurjchem-2455	376	1	ruiz	ruiz	NOUN
eurjchem-2455	376	2	-	-	PUNCT
eurjchem-2455	376	3	morales	morale	NOUN
eurjchem-2455	376	4	,	,	PUNCT
eurjchem-2455	376	5	y.	y.	PROPN
eurjchem-2455	376	6	homo−lumo	homo−lumo	PROPN
eurjchem-2455	376	7	gap	gap	NOUN
eurjchem-2455	376	8	as	as	ADP
eurjchem-2455	376	9	an	an	DET
eurjchem-2455	376	10	index	index	NOUN
eurjchem-2455	376	11	of	of	ADP
eurjchem-2455	376	12	molecular	molecular	ADJ
eurjchem-2455	376	13	size	size	NOUN
eurjchem-2455	376	14	and	and	CCONJ
eurjchem-2455	376	15	structure	structure	NOUN
eurjchem-2455	376	16	for	for	ADP
eurjchem-2455	376	17	polycyclic	polycyclic	ADJ
eurjchem-2455	376	18	aromatic	aromatic	ADJ
eurjchem-2455	376	19	hydrocarbons	hydrocarbon	NOUN
eurjchem-2455	376	20	(	(	PUNCT
eurjchem-2455	376	21	pahs	pahs	PROPN
eurjchem-2455	376	22	)	)	PUNCT
eurjchem-2455	376	23	and	and	CCONJ
eurjchem-2455	376	24	asphaltenes	asphaltene	NOUN
eurjchem-2455	376	25	:	:	PUNCT
eurjchem-2455	376	26	a	a	DET
eurjchem-2455	376	27	theoretical	theoretical	ADJ
eurjchem-2455	376	28	study	study	NOUN
eurjchem-2455	376	29	.	.	PUNCT
eurjchem-2455	377	1	i.	i.	PROPN
eurjchem-2455	377	2	j.	j.	PROPN
eurjchem-2455	377	3	phys	phys	PROPN
eurjchem-2455	377	4	.	.	PUNCT
eurjchem-2455	378	1	chem	chem	PROPN
eurjchem-2455	378	2	.	.	PUNCT
eurjchem-2455	379	1	a	a	DET
eurjchem-2455	379	2	2002	2002	NUM
eurjchem-2455	379	3	,	,	PUNCT
eurjchem-2455	379	4	106	106	NUM
eurjchem-2455	379	5	,	,	PUNCT
eurjchem-2455	379	6	11283	11283	NUM
eurjchem-2455	379	7	–	–	PUNCT
eurjchem-2455	379	8	11308	11308	NUM
eurjchem-2455	379	9	.	.	PUNCT
eurjchem-2455	380	1	[	[	X
eurjchem-2455	380	2	47	47	NUM
eurjchem-2455	380	3	]	]	PUNCT
eurjchem-2455	380	4	.	.	PUNCT
eurjchem-2455	380	5	mumit	mumit	NOUN
eurjchem-2455	380	6	,	,	PUNCT
eurjchem-2455	380	7	m.	m.	NOUN
eurjchem-2455	380	8	a.	a.	NOUN
eurjchem-2455	380	9	;	;	PUNCT
eurjchem-2455	380	10	pal	pal	NOUN
eurjchem-2455	380	11	,	,	PUNCT
eurjchem-2455	380	12	t.	t.	PROPN
eurjchem-2455	380	13	k.	k.	PROPN
eurjchem-2455	380	14	;	;	PUNCT
eurjchem-2455	380	15	alam	alam	PROPN
eurjchem-2455	380	16	,	,	PUNCT
eurjchem-2455	380	17	m.	m.	NOUN
eurjchem-2455	380	18	a.	a.	PROPN
eurjchem-2455	380	19	;	;	PUNCT
eurjchem-2455	380	20	islam	islam	PROPN
eurjchem-2455	380	21	,	,	PUNCT
eurjchem-2455	380	22	m.	m.	NOUN
eurjchem-2455	380	23	a.-a.-a.-a	a.-a.-a.-a	PROPN
eurjchem-2455	380	24	.	.	PUNCT
eurjchem-2455	380	25	;	;	PUNCT
eurjchem-2455	380	26	paul	paul	PROPN
eurjchem-2455	380	27	,	,	PUNCT
eurjchem-2455	380	28	s.	s.	PROPN
eurjchem-2455	380	29	;	;	PUNCT
eurjchem-2455	380	30	sheikh	sheikh	PROPN
eurjchem-2455	380	31	,	,	PUNCT
eurjchem-2455	380	32	m.	m.	PROPN
eurjchem-2455	380	33	c.	c.	PROPN
eurjchem-2455	380	34	dft	dft	PROPN
eurjchem-2455	380	35	studies	study	NOUN
eurjchem-2455	380	36	on	on	ADP
eurjchem-2455	380	37	vibrational	vibrational	ADJ
eurjchem-2455	380	38	and	and	CCONJ
eurjchem-2455	380	39	electronic	electronic	ADJ
eurjchem-2455	380	40	spectra	spectra	NOUN
eurjchem-2455	380	41	,	,	PUNCT
eurjchem-2455	380	42	homo	homo	NOUN
eurjchem-2455	380	43	–	–	PUNCT
eurjchem-2455	380	44	lumo	lumo	NOUN
eurjchem-2455	380	45	,	,	PUNCT
eurjchem-2455	380	46	mep	mep	PROPN
eurjchem-2455	380	47	,	,	PUNCT
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eurjchem-2455	380	49	,	,	PUNCT
eurjchem-2455	380	50	nbo	nbo	PROPN
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eurjchem-2455	380	56	benzyl-3	benzyl-3	PROPN
eurjchem-2455	380	57	-	-	PUNCT
eurjchem-2455	380	58	n-(2,4,5trimethoxyphenylmethylene)hydrazinecarbodithioate	n-(2,4,5trimethoxyphenylmethylene)hydrazinecarbodithioate	PROPN
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eurjchem-2455	381	1	j.	j.	PROPN
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eurjchem-2455	382	2	,	,	PUNCT
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eurjchem-2455	382	4	,	,	PUNCT
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eurjchem-2455	382	6	.	.	PUNCT
eurjchem-2455	383	1	[	[	X
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eurjchem-2455	383	3	]	]	PUNCT
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eurjchem-2455	383	23	.	.	PUNCT
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eurjchem-2455	386	2	,	,	PUNCT
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eurjchem-2455	387	1	[	[	X
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eurjchem-2455	387	3	]	]	PUNCT
eurjchem-2455	387	4	.	.	PUNCT
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eurjchem-2455	388	21	)	)	PUNCT
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eurjchem-2455	388	29	.	.	PUNCT
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eurjchem-2455	389	2	.	.	PUNCT
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eurjchem-2455	390	2	.	.	PUNCT
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eurjchem-2455	391	4	,	,	PUNCT
eurjchem-2455	391	5	16–21	16–21	NUM
eurjchem-2455	391	6	.	.	PUNCT
eurjchem-2455	392	1	[	[	X
eurjchem-2455	392	2	50	50	NUM
eurjchem-2455	392	3	]	]	PUNCT
eurjchem-2455	392	4	.	.	PUNCT
eurjchem-2455	393	1	volkenstein	volkenstein	PROPN
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eurjchem-2455	393	9	non	non	ADJ
eurjchem-2455	393	10	-	-	ADJ
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eurjchem-2455	393	12	amino	amino	NOUN
eurjchem-2455	393	13	-	-	PUNCT
eurjchem-2455	393	14	acids	acid	NOUN
eurjchem-2455	393	15	.	.	PUNCT
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eurjchem-2455	394	3	,	,	PUNCT
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eurjchem-2455	394	5	,	,	PUNCT
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eurjchem-2455	395	1	[	[	X
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eurjchem-2455	395	3	]	]	PUNCT
eurjchem-2455	395	4	.	.	PUNCT
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eurjchem-2455	396	4	;	;	PUNCT
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eurjchem-2455	396	7	a.	a.	PROPN
eurjchem-2455	396	8	e.	e.	PROPN
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eurjchem-2455	397	1	barakat	barakat	PROPN
eurjchem-2455	397	2	,	,	PUNCT
eurjchem-2455	397	3	a.	a.	PROPN
eurjchem-2455	397	4	;	;	PUNCT
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eurjchem-2455	397	9	;	;	PUNCT
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eurjchem-2455	397	18	;	;	PUNCT
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eurjchem-2455	397	39	dow	dow	PROPN
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eurjchem-2455	397	45	,	,	PUNCT
eurjchem-2455	397	46	o.	o.	PROPN
eurjchem-2455	397	47	o.	o.	PROPN
eurjchem-2455	397	48	;	;	PUNCT
eurjchem-2455	397	49	feng	feng	PROPN
eurjchem-2455	397	50	,	,	PUNCT
eurjchem-2455	397	51	x.	x.	PROPN
eurjchem-2455	397	52	;	;	PUNCT
eurjchem-2455	397	53	france	france	PROPN
eurjchem-2455	397	54	,	,	PUNCT
eurjchem-2455	397	55	s.	s.	PROPN
eurjchem-2455	397	56	p.	p.	PROPN
eurjchem-2455	397	57	;	;	PUNCT
eurjchem-2455	398	1	howard	howard	PROPN
eurjchem-2455	398	2	,	,	PUNCT
eurjchem-2455	398	3	r.	r.	PROPN
eurjchem-2455	398	4	m.	m.	PROPN
eurjchem-2455	398	5	;	;	PUNCT
eurjchem-2455	398	6	janz	janz	PROPN
eurjchem-2455	398	7	,	,	PUNCT
eurjchem-2455	398	8	j.	j.	PROPN
eurjchem-2455	398	9	m.	m.	PROPN
eurjchem-2455	398	10	;	;	PUNCT
eurjchem-2455	398	11	jasti	jasti	PROPN
eurjchem-2455	398	12	,	,	PUNCT
eurjchem-2455	398	13	j.	j.	PROPN
eurjchem-2455	398	14	;	;	PUNCT
eurjchem-2455	398	15	jasuja	jasuja	PROPN
eurjchem-2455	398	16	,	,	PUNCT
eurjchem-2455	398	17	r.	r.	PROPN
eurjchem-2455	398	18	;	;	PUNCT
eurjchem-2455	398	19	jones	jones	PROPN
eurjchem-2455	398	20	,	,	PUNCT
eurjchem-2455	398	21	l.	l.	PROPN
eurjchem-2455	398	22	h.	h.	PROPN
eurjchem-2455	398	23	;	;	PUNCT
eurjchem-2455	398	24	king	king	NOUN
eurjchem-2455	398	25	-	-	PUNCT
eurjchem-2455	398	26	ahmad	ahmad	PROPN
eurjchem-2455	398	27	,	,	PUNCT
eurjchem-2455	398	28	a.	a.	NOUN
eurjchem-2455	398	29	;	;	PUNCT
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eurjchem-2455	398	39	;	;	PUNCT
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eurjchem-2455	398	43	;	;	PUNCT
eurjchem-2455	398	44	liras	liras	PROPN
eurjchem-2455	398	45	,	,	PUNCT
eurjchem-2455	398	46	s.	s.	PROPN
eurjchem-2455	398	47	;	;	PUNCT
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eurjchem-2455	398	50	c.	c.	PROPN
eurjchem-2455	398	51	a.	a.	PROPN
eurjchem-2455	398	52	;	;	PUNCT
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eurjchem-2455	398	54	,	,	PUNCT
eurjchem-2455	398	55	k.	k.	PROPN
eurjchem-2455	398	56	f.	f.	PROPN
eurjchem-2455	398	57	;	;	PUNCT
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eurjchem-2455	398	59	,	,	PUNCT
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eurjchem-2455	398	61	;	;	PUNCT
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eurjchem-2455	398	83	d.	d.	PROPN
eurjchem-2455	398	84	w.	w.	PROPN
eurjchem-2455	398	85	;	;	PUNCT
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eurjchem-2455	398	87	,	,	PUNCT
eurjchem-2455	398	88	o.	o.	PROPN
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eurjchem-2455	398	94	;	;	PUNCT
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eurjchem-2455	398	99	;	;	PUNCT
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eurjchem-2455	398	103	;	;	PUNCT
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eurjchem-2455	398	105	,	,	PUNCT
eurjchem-2455	398	106	b.	b.	PROPN
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eurjchem-2455	398	108	;	;	PUNCT
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eurjchem-2455	398	111	d.	d.	PROPN
eurjchem-2455	398	112	;	;	PUNCT
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eurjchem-2455	398	125	m.	m.	PROPN
eurjchem-2455	398	126	;	;	PUNCT
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eurjchem-2455	398	129	j.	j.	PROPN
eurjchem-2455	398	130	;	;	PUNCT
eurjchem-2455	398	131	yayla	yayla	PROPN
eurjchem-2455	398	132	,	,	PUNCT
eurjchem-2455	398	133	h.	h.	PROPN
eurjchem-2455	398	134	g.	g.	PROPN
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eurjchem-2455	398	146	cell	cell	NOUN
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eurjchem-2455	399	1	j.	j.	PROPN
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eurjchem-2455	401	1	[	[	X
eurjchem-2455	401	2	52	52	NUM
eurjchem-2455	401	3	]	]	PUNCT
eurjchem-2455	401	4	.	.	PUNCT
eurjchem-2455	402	1	moioli	moioli	PROPN
eurjchem-2455	402	2	,	,	PUNCT
eurjchem-2455	402	3	e.	e.	PROPN
eurjchem-2455	402	4	;	;	PUNCT
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eurjchem-2455	402	7	l.	l.	PROPN
eurjchem-2455	402	8	;	;	PUNCT
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eurjchem-2455	402	12	;	;	PUNCT
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eurjchem-2455	402	21	–	–	PUNCT
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eurjchem-2455	403	1	react	react	VERB
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eurjchem-2455	405	8	.	.	PUNCT
eurjchem-2455	406	1	copyright	copyright	NOUN
eurjchem-2455	406	2	©	©	PROPN
eurjchem-2455	406	3	2023	2023	NUM
eurjchem-2455	406	4	by	by	ADP
eurjchem-2455	406	5	authors	author	NOUN
eurjchem-2455	406	6	.	.	PUNCT
eurjchem-2455	407	1	this	this	DET
eurjchem-2455	407	2	work	work	NOUN
eurjchem-2455	407	3	is	be	AUX
eurjchem-2455	407	4	published	publish	VERB
eurjchem-2455	407	5	and	and	CCONJ
eurjchem-2455	407	6	licensed	license	VERB
eurjchem-2455	407	7	by	by	ADP
eurjchem-2455	407	8	atlanta	atlanta	PROPN
eurjchem-2455	407	9	publishing	publishing	PROPN
eurjchem-2455	407	10	house	house	PROPN
eurjchem-2455	407	11	llc	llc	PROPN
eurjchem-2455	407	12	,	,	PUNCT
eurjchem-2455	407	13	atlanta	atlanta	PROPN
eurjchem-2455	407	14	,	,	PUNCT
eurjchem-2455	407	15	ga	ga	PROPN
eurjchem-2455	407	16	,	,	PUNCT
eurjchem-2455	407	17	usa	usa	PROPN
eurjchem-2455	407	18	.	.	PUNCT
eurjchem-2455	408	1	the	the	DET
eurjchem-2455	408	2	full	full	ADJ
eurjchem-2455	408	3	terms	term	NOUN
eurjchem-2455	408	4	of	of	ADP
eurjchem-2455	408	5	this	this	DET
eurjchem-2455	408	6	license	license	NOUN
eurjchem-2455	408	7	are	be	AUX
eurjchem-2455	408	8	available	available	ADJ
eurjchem-2455	408	9	at	at	ADP
eurjchem-2455	408	10	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	NOUN
eurjchem-2455	408	11	and	and	CCONJ
eurjchem-2455	408	12	incorporate	incorporate	VERB
eurjchem-2455	408	13	the	the	DET
eurjchem-2455	408	14	creative	creative	ADJ
eurjchem-2455	408	15	commons	common	NOUN
eurjchem-2455	408	16	attribution	attribution	NOUN
eurjchem-2455	408	17	-	-	PUNCT
eurjchem-2455	408	18	non	non	ADJ
eurjchem-2455	408	19	commercial	commercial	NOUN
eurjchem-2455	408	20	(	(	PUNCT
eurjchem-2455	408	21	cc	cc	NOUN
eurjchem-2455	408	22	by	by	ADP
eurjchem-2455	408	23	nc	nc	PROPN
eurjchem-2455	408	24	)	)	PUNCT
eurjchem-2455	408	25	(	(	PUNCT
eurjchem-2455	408	26	international	international	ADJ
eurjchem-2455	408	27	,	,	PUNCT
eurjchem-2455	408	28	v4.0	v4.0	NOUN
eurjchem-2455	408	29	)	)	PUNCT
eurjchem-2455	408	30	license	license	NOUN
eurjchem-2455	408	31	(	(	PUNCT
eurjchem-2455	408	32	http://creativecommons.org/licenses/by-nc/4.0	http://creativecommons.org/licenses/by-nc/4.0	NOUN
eurjchem-2455	408	33	)	)	PUNCT
eurjchem-2455	408	34	.	.	PUNCT
eurjchem-2455	409	1	by	by	ADP
eurjchem-2455	409	2	accessing	access	VERB
eurjchem-2455	409	3	the	the	DET
eurjchem-2455	409	4	work	work	NOUN
eurjchem-2455	409	5	,	,	PUNCT
eurjchem-2455	409	6	you	you	PRON
eurjchem-2455	409	7	hereby	hereby	ADV
eurjchem-2455	409	8	accept	accept	VERB
eurjchem-2455	409	9	the	the	DET
eurjchem-2455	409	10	terms	term	NOUN
eurjchem-2455	409	11	.	.	PUNCT
eurjchem-2455	410	1	this	this	PRON
eurjchem-2455	410	2	is	be	AUX
eurjchem-2455	410	3	an	an	DET
eurjchem-2455	410	4	open	open	ADJ
eurjchem-2455	410	5	access	access	NOUN
eurjchem-2455	410	6	article	article	NOUN
eurjchem-2455	410	7	distributed	distribute	VERB
eurjchem-2455	410	8	under	under	ADP
eurjchem-2455	410	9	the	the	DET
eurjchem-2455	410	10	terms	term	NOUN
eurjchem-2455	410	11	and	and	CCONJ
eurjchem-2455	410	12	conditions	condition	NOUN
eurjchem-2455	410	13	of	of	ADP
eurjchem-2455	410	14	the	the	DET
eurjchem-2455	410	15	cc	cc	PROPN
eurjchem-2455	410	16	by	by	ADP
eurjchem-2455	410	17	nc	nc	PROPN
eurjchem-2455	410	18	license	license	PROPN
eurjchem-2455	410	19	,	,	PUNCT
eurjchem-2455	410	20	which	which	PRON
eurjchem-2455	410	21	permits	permit	VERB
eurjchem-2455	410	22	unrestricted	unrestricted	ADJ
eurjchem-2455	410	23	non	non	ADJ
eurjchem-2455	410	24	-	-	ADJ
eurjchem-2455	410	25	commercial	commercial	ADJ
eurjchem-2455	410	26	use	use	NOUN
eurjchem-2455	410	27	,	,	PUNCT
eurjchem-2455	410	28	distribution	distribution	NOUN
eurjchem-2455	410	29	,	,	PUNCT
eurjchem-2455	410	30	and	and	CCONJ
eurjchem-2455	410	31	reproduction	reproduction	NOUN
eurjchem-2455	410	32	in	in	ADP
eurjchem-2455	410	33	any	any	DET
eurjchem-2455	410	34	medium	medium	NOUN
eurjchem-2455	410	35	,	,	PUNCT
eurjchem-2455	410	36	provided	provide	VERB
eurjchem-2455	410	37	the	the	DET
eurjchem-2455	410	38	original	original	ADJ
eurjchem-2455	410	39	work	work	NOUN
eurjchem-2455	410	40	is	be	AUX
eurjchem-2455	410	41	properly	properly	ADV
eurjchem-2455	410	42	cited	cite	VERB
eurjchem-2455	410	43	without	without	ADP
eurjchem-2455	410	44	any	any	DET
eurjchem-2455	410	45	further	further	ADJ
eurjchem-2455	410	46	permission	permission	NOUN
eurjchem-2455	410	47	from	from	ADP
eurjchem-2455	410	48	atlanta	atlanta	PROPN
eurjchem-2455	410	49	publishing	publishing	PROPN
eurjchem-2455	410	50	house	house	PROPN
eurjchem-2455	410	51	llc	llc	PROPN
eurjchem-2455	410	52	(	(	PUNCT
eurjchem-2455	410	53	european	european	PROPN
eurjchem-2455	410	54	journal	journal	PROPN
eurjchem-2455	410	55	of	of	ADP
eurjchem-2455	410	56	chemistry	chemistry	NOUN
eurjchem-2455	410	57	)	)	PUNCT
eurjchem-2455	410	58	.	.	PUNCT
eurjchem-2455	411	1	no	no	DET
eurjchem-2455	411	2	use	use	NOUN
eurjchem-2455	411	3	,	,	PUNCT
eurjchem-2455	411	4	distribution	distribution	NOUN
eurjchem-2455	411	5	,	,	PUNCT
eurjchem-2455	411	6	or	or	CCONJ
eurjchem-2455	411	7	reproduction	reproduction	NOUN
eurjchem-2455	411	8	is	be	AUX
eurjchem-2455	411	9	permitted	permit	VERB
eurjchem-2455	411	10	which	which	PRON
eurjchem-2455	411	11	does	do	AUX
eurjchem-2455	411	12	not	not	PART
eurjchem-2455	411	13	comply	comply	VERB
eurjchem-2455	411	14	with	with	ADP
eurjchem-2455	411	15	these	these	DET
eurjchem-2455	411	16	terms	term	NOUN
eurjchem-2455	411	17	.	.	PUNCT
eurjchem-2455	412	1	permissions	permission	NOUN
eurjchem-2455	412	2	for	for	ADP
eurjchem-2455	412	3	commercial	commercial	ADJ
eurjchem-2455	412	4	use	use	NOUN
eurjchem-2455	412	5	of	of	ADP
eurjchem-2455	412	6	this	this	DET
eurjchem-2455	412	7	work	work	NOUN
eurjchem-2455	412	8	beyond	beyond	ADP
eurjchem-2455	412	9	the	the	DET
eurjchem-2455	412	10	scope	scope	NOUN
eurjchem-2455	412	11	of	of	ADP
eurjchem-2455	412	12	the	the	DET
eurjchem-2455	412	13	license	license	NOUN
eurjchem-2455	412	14	(	(	PUNCT
eurjchem-2455	412	15	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	NOUN
eurjchem-2455	412	16	)	)	PUNCT
eurjchem-2455	412	17	are	be	AUX
eurjchem-2455	412	18	administered	administer	VERB
eurjchem-2455	412	19	by	by	ADP
eurjchem-2455	412	20	atlanta	atlanta	PROPN
eurjchem-2455	412	21	publishing	publishing	PROPN
eurjchem-2455	412	22	house	house	PROPN
eurjchem-2455	412	23	llc	llc	PROPN
eurjchem-2455	412	24	(	(	PUNCT
eurjchem-2455	412	25	european	european	PROPN
eurjchem-2455	412	26	journal	journal	PROPN
eurjchem-2455	412	27	of	of	ADP
eurjchem-2455	412	28	chemistry	chemistry	NOUN
eurjchem-2455	412	29	)	)	PUNCT
eurjchem-2455	412	30	.	.	PUNCT
eurjchem-2455	413	1	https://discover.3ds.com/discovery-studio-visualizer-download	https://discover.3ds.com/discovery-studio-visualizer-download	PROPN
eurjchem-2455	414	1	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	PROPN
eurjchem-2455	414	2	http://creativecommons.org/licenses/by-nc/4.0	http://creativecommons.org/licenses/by-nc/4.0	PROPN
eurjchem-2455	414	3	http://www.eurjchem.com/index.php/eurjchem/pages/view/terms	http://www.eurjchem.com/index.php/eurjchem/pages/view/term	NOUN
eurjchem-2455	414	4	1	1	NUM
eurjchem-2455	414	5	.	.	PUNCT
eurjchem-2455	414	6	introduction	introduction	NOUN
eurjchem-2455	414	7	2	2	NUM
eurjchem-2455	414	8	.	.	PUNCT
eurjchem-2455	414	9	experimental	experimental	ADJ
eurjchem-2455	414	10	2.1	2.1	NUM
eurjchem-2455	414	11	.	.	PUNCT
eurjchem-2455	414	12	software	software	NOUN
eurjchem-2455	414	13	and	and	CCONJ
eurjchem-2455	414	14	tools	tool	NOUN
eurjchem-2455	414	15	2.2	2.2	NUM
eurjchem-2455	414	16	.	.	PUNCT
eurjchem-2455	415	1	simulation	simulation	NOUN
eurjchem-2455	415	2	method	method	PROPN
eurjchem-2455	415	3	3	3	NUM
eurjchem-2455	415	4	.	.	NOUN
eurjchem-2455	415	5	results	result	NOUN
eurjchem-2455	415	6	and	and	CCONJ
eurjchem-2455	415	7	discussion	discussion	NOUN
eurjchem-2455	415	8	4	4	NUM
eurjchem-2455	415	9	.	.	PUNCT
eurjchem-2455	416	1	gaps	gap	NOUN
eurjchem-2455	416	2	in	in	ADP
eurjchem-2455	416	3	the	the	DET
eurjchem-2455	416	4	development	development	NOUN
eurjchem-2455	416	5	of	of	ADP
eurjchem-2455	416	6	anti	anti	ADJ
eurjchem-2455	416	7	-	-	ADJ
eurjchem-2455	416	8	sickling	sickling	ADJ
eurjchem-2455	416	9	agents	agent	NOUN
eurjchem-2455	416	10	5	5	NUM
eurjchem-2455	416	11	.	.	PUNCT
eurjchem-2455	417	1	the	the	DET
eurjchem-2455	417	2	tactic	tactic	NOUN
eurjchem-2455	417	3	for	for	ADP
eurjchem-2455	417	4	the	the	DET
eurjchem-2455	417	5	selection	selection	NOUN
eurjchem-2455	417	6	of	of	ADP
eurjchem-2455	417	7	a	a	DET
eurjchem-2455	417	8	more	more	ADV
eurjchem-2455	417	9	potent	potent	ADJ
eurjchem-2455	417	10	anti	anti	ADJ
eurjchem-2455	417	11	-	-	ADJ
eurjchem-2455	417	12	sickling	sickling	ADJ
eurjchem-2455	417	13	drug	drug	NOUN
eurjchem-2455	417	14	before	before	ADP
eurjchem-2455	417	15	synthesis	synthesis	NOUN
eurjchem-2455	417	16	6	6	NUM
eurjchem-2455	417	17	.	.	PUNCT
eurjchem-2455	418	1	conclusion	conclusion	NOUN
eurjchem-2455	418	2	supporting	support	VERB
eurjchem-2455	418	3	information	information	NOUN
eurjchem-2455	418	4	acknowledgements	acknowledgement	NOUN
eurjchem-2455	418	5	disclosure	disclosure	NOUN
eurjchem-2455	418	6	statement	statement	NOUN
eurjchem-2455	418	7	credit	credit	NOUN
eurjchem-2455	418	8	authorship	authorship	NOUN
eurjchem-2455	418	9	contribution	contribution	NOUN
eurjchem-2455	418	10	statement	statement	NOUN
eurjchem-2455	418	11	orcid	orcid	NOUN
eurjchem-2455	418	12	and	and	CCONJ
eurjchem-2455	418	13	email	email	NOUN
eurjchem-2455	418	14	references	reference	NOUN
eurjchem-2455	418	15	printfield10	printfield10	PROPN
eurjchem-2455	418	16	:	:	PUNCT
eurjchem-2455	418	17	printfield11	printfield11	NOUN
eurjchem-2455	418	18	:	:	PUNCT
eurjchem-2455	418	19	printfield12	printfield12	PROPN
eurjchem-2455	418	20	:	:	PUNCT
eurjchem-2455	418	21	printfield13	printfield13	VERB
eurjchem-2455	418	22	:	:	PUNCT
eurjchem-2455	418	23	printfield14	printfield14	NOUN
eurjchem-2455	418	24	:	:	PUNCT
eurjchem-2455	418	25	printfield15	printfield15	NOUN
eurjchem-2455	418	26	:	:	PUNCT
eurjchem-2455	418	27	printfield20	printfield20	PROPN
eurjchem-2455	418	28	:	:	PUNCT
eurjchem-2455	418	29	printfield21	printfield21	ADJ
eurjchem-2455	418	30	:	:	PUNCT
eurjchem-2455	418	31	printfield22	printfield22	NOUN
eurjchem-2455	418	32	:	:	PUNCT
eurjchem-2455	418	33	printfield23	printfield23	NOUN
eurjchem-2455	418	34	:	:	PUNCT
eurjchem-2455	418	35	printfield24	printfield24	NOUN
eurjchem-2455	418	36	:	:	PUNCT
eurjchem-2455	418	37	printfield25	printfield25	NOUN
eurjchem-2455	418	38	:	:	PUNCT