id	sid	tid	token	lemma	pos
eurjchem-2534	1	1	exploring	explore	VERB
eurjchem-2534	1	2	medicinal	medicinal	ADJ
eurjchem-2534	1	3	potential	potential	ADJ
eurjchem-2534	1	4	and	and	CCONJ
eurjchem-2534	1	5	drug	drug	NOUN
eurjchem-2534	1	6	delivery	delivery	NOUN
eurjchem-2534	1	7	solutions	solution	NOUN
eurjchem-2534	1	8	of	of	ADP
eurjchem-2534	1	9	celastrol	celastrol	NOUN
eurjchem-2534	1	10	from	from	ADP
eurjchem-2534	1	11	the	the	DET
eurjchem-2534	1	12	chinese	chinese	ADJ
eurjchem-2534	1	13	"	"	PUNCT
eurjchem-2534	1	14	thunder	thunder	NOUN
eurjchem-2534	1	15	of	of	ADP
eurjchem-2534	1	16	god	god	PROPN
eurjchem-2534	1	17	vine	vine	NOUN
eurjchem-2534	1	18	"	"	PUNCT
eurjchem-2534	1	19	european	european	PROPN
eurjchem-2534	1	20	journal	journal	PROPN
eurjchem-2534	1	21	of	of	ADP
eurjchem-2534	1	22	chemistry	chemistry	NOUN
eurjchem-2534	1	23	15	15	NUM
eurjchem-2534	1	24	(	(	PUNCT
eurjchem-2534	1	25	2	2	NUM
eurjchem-2534	1	26	)	)	PUNCT
eurjchem-2534	1	27	(	(	PUNCT
eurjchem-2534	1	28	2024	2024	NUM
eurjchem-2534	1	29	)	)	PUNCT
eurjchem-2534	1	30	194	194	NUM
eurjchem-2534	1	31	-	-	SYM
eurjchem-2534	1	32	204	204	NUM
eurjchem-2534	1	33	european	european	ADJ
eurjchem-2534	1	34	journal	journal	NOUN
eurjchem-2534	1	35	of	of	ADP
eurjchem-2534	1	36	chemistry	chemistry	NOUN
eurjchem-2534	1	37	issn	issn	VERB
eurjchem-2534	1	38	2153	2153	NUM
eurjchem-2534	1	39	-	-	SYM
eurjchem-2534	1	40	2249	2249	NUM
eurjchem-2534	1	41	(	(	PUNCT
eurjchem-2534	1	42	print	print	NOUN
eurjchem-2534	1	43	)	)	PUNCT
eurjchem-2534	1	44	/	/	PUNCT
eurjchem-2534	1	45	issn	issn	PROPN
eurjchem-2534	1	46	2153	2153	NUM
eurjchem-2534	1	47	-	-	SYM
eurjchem-2534	1	48	2257	2257	NUM
eurjchem-2534	1	49	(	(	PUNCT
eurjchem-2534	1	50	online	online	ADJ
eurjchem-2534	1	51	)	)	PUNCT
eurjchem-2534	1	52	–	–	PUNCT
eurjchem-2534	1	53	copyright	copyright	NOUN
eurjchem-2534	1	54	©	©	PROPN
eurjchem-2534	1	55	2024	2024	NUM
eurjchem-2534	1	56	the	the	DET
eurjchem-2534	1	57	authors	author	NOUN
eurjchem-2534	1	58	–	–	PUNCT
eurjchem-2534	1	59	atlanta	atlanta	PROPN
eurjchem-2534	1	60	publishing	publishing	PROPN
eurjchem-2534	1	61	house	house	PROPN
eurjchem-2534	1	62	llc	llc	PROPN
eurjchem-2534	1	63	–	–	PUNCT
eurjchem-2534	1	64	printed	print	VERB
eurjchem-2534	1	65	in	in	ADP
eurjchem-2534	1	66	the	the	DET
eurjchem-2534	1	67	usa	usa	PROPN
eurjchem-2534	1	68	.	.	PUNCT
eurjchem-2534	2	1	this	this	DET
eurjchem-2534	2	2	work	work	NOUN
eurjchem-2534	2	3	is	be	AUX
eurjchem-2534	2	4	published	publish	VERB
eurjchem-2534	2	5	and	and	CCONJ
eurjchem-2534	2	6	licensed	license	VERB
eurjchem-2534	2	7	by	by	ADP
eurjchem-2534	2	8	atlanta	atlanta	PROPN
eurjchem-2534	2	9	publishing	publishing	PROPN
eurjchem-2534	2	10	house	house	PROPN
eurjchem-2534	2	11	llc	llc	PROPN
eurjchem-2534	2	12	–	–	PUNCT
eurjchem-2534	2	13	cc	cc	PROPN
eurjchem-2534	2	14	by	by	ADP
eurjchem-2534	2	15	nc	nc	PROPN
eurjchem-2534	2	16	–	–	PUNCT
eurjchem-2534	2	17	some	some	DET
eurjchem-2534	2	18	rights	right	NOUN
eurjchem-2534	2	19	reserved	reserve	VERB
eurjchem-2534	2	20	.	.	PUNCT
eurjchem-2534	3	1	https://dx.doi.org/10.5155/eurjchem.15.2.194-204.2534	https://dx.doi.org/10.5155/eurjchem.15.2.194-204.2534	ADJ
eurjchem-2534	3	2	european	european	ADJ
eurjchem-2534	3	3	journal	journal	PROPN
eurjchem-2534	3	4	of	of	ADP
eurjchem-2534	3	5	chemistry	chemistry	NOUN
eurjchem-2534	3	6	view	view	NOUN
eurjchem-2534	3	7	journal	journal	PROPN
eurjchem-2534	3	8	online	online	PROPN
eurjchem-2534	3	9	view	view	NOUN
eurjchem-2534	3	10	article	article	NOUN
eurjchem-2534	3	11	online	online	ADV
eurjchem-2534	3	12	exploring	explore	VERB
eurjchem-2534	3	13	medicinal	medicinal	ADJ
eurjchem-2534	3	14	potential	potential	ADJ
eurjchem-2534	3	15	and	and	CCONJ
eurjchem-2534	3	16	drug	drug	NOUN
eurjchem-2534	3	17	delivery	delivery	NOUN
eurjchem-2534	3	18	solutions	solution	NOUN
eurjchem-2534	3	19	of	of	ADP
eurjchem-2534	3	20	celastrol	celastrol	NOUN
eurjchem-2534	3	21	from	from	ADP
eurjchem-2534	3	22	the	the	DET
eurjchem-2534	3	23	chinese	chinese	ADJ
eurjchem-2534	3	24	"	"	PUNCT
eurjchem-2534	3	25	thunder	thunder	NOUN
eurjchem-2534	3	26	of	of	ADP
eurjchem-2534	3	27	god	god	PROPN
eurjchem-2534	3	28	vine	vine	NOUN
eurjchem-2534	3	29	"	"	PUNCT
eurjchem-2534	3	30	zimo	zimo	PROPN
eurjchem-2534	3	31	ren	ren	PROPN
eurjchem-2534	3	32	and	and	CCONJ
eurjchem-2534	3	33	paolo	paolo	PROPN
eurjchem-2534	3	34	coghi	coghi	PROPN
eurjchem-2534	3	35	*	*	PUNCT
eurjchem-2534	3	36	department	department	PROPN
eurjchem-2534	3	37	of	of	ADP
eurjchem-2534	3	38	medical	medical	ADJ
eurjchem-2534	3	39	division	division	NOUN
eurjchem-2534	3	40	,	,	PUNCT
eurjchem-2534	3	41	school	school	NOUN
eurjchem-2534	3	42	of	of	ADP
eurjchem-2534	3	43	pharmacy	pharmacy	NOUN
eurjchem-2534	3	44	,	,	PUNCT
eurjchem-2534	3	45	macau	macau	PROPN
eurjchem-2534	3	46	university	university	PROPN
eurjchem-2534	3	47	of	of	ADP
eurjchem-2534	3	48	science	science	NOUN
eurjchem-2534	3	49	and	and	CCONJ
eurjchem-2534	3	50	technology	technology	NOUN
eurjchem-2534	3	51	,	,	PUNCT
eurjchem-2534	3	52	macau	macau	PROPN
eurjchem-2534	3	53	,	,	PUNCT
eurjchem-2534	3	54	999078	999078	NUM
eurjchem-2534	3	55	,	,	PUNCT
eurjchem-2534	3	56	china	china	PROPN
eurjchem-2534	3	57	*	*	PUNCT
eurjchem-2534	3	58	corresponding	correspond	VERB
eurjchem-2534	3	59	author	author	NOUN
eurjchem-2534	3	60	at	at	ADP
eurjchem-2534	3	61	:	:	PUNCT
eurjchem-2534	3	62	department	department	NOUN
eurjchem-2534	3	63	of	of	ADP
eurjchem-2534	3	64	medical	medical	ADJ
eurjchem-2534	3	65	division	division	NOUN
eurjchem-2534	3	66	,	,	PUNCT
eurjchem-2534	3	67	school	school	NOUN
eurjchem-2534	3	68	of	of	ADP
eurjchem-2534	3	69	pharmacy	pharmacy	NOUN
eurjchem-2534	3	70	,	,	PUNCT
eurjchem-2534	3	71	macau	macau	PROPN
eurjchem-2534	3	72	university	university	PROPN
eurjchem-2534	3	73	of	of	ADP
eurjchem-2534	3	74	science	science	NOUN
eurjchem-2534	3	75	and	and	CCONJ
eurjchem-2534	3	76	technology	technology	NOUN
eurjchem-2534	3	77	,	,	PUNCT
eurjchem-2534	3	78	macau	macau	PROPN
eurjchem-2534	3	79	,	,	PUNCT
eurjchem-2534	3	80	999078	999078	NUM
eurjchem-2534	3	81	,	,	PUNCT
eurjchem-2534	3	82	china	china	PROPN
eurjchem-2534	3	83	.	.	PUNCT
eurjchem-2534	4	1	e	e	X
eurjchem-2534	4	2	-	-	NOUN
eurjchem-2534	4	3	mail	mail	NOUN
eurjchem-2534	4	4	:	:	PUNCT
eurjchem-2534	4	5	coghips@must.edu.mo	coghips@must.edu.mo	NOUN
eurjchem-2534	4	6	(	(	PUNCT
eurjchem-2534	4	7	p.	p.	PROPN
eurjchem-2534	4	8	coghi	coghi	PROPN
eurjchem-2534	4	9	)	)	PUNCT
eurjchem-2534	4	10	.	.	PUNCT
eurjchem-2534	5	1	10.5155	10.5155	NUM
eurjchem-2534	5	2	/	/	SYM
eurjchem-2534	5	3	eurjchem.15.2.194	eurjchem.15.2.194	NUM
eurjchem-2534	5	4	-	-	SYM
eurjchem-2534	5	5	204.2534	204.2534	NUM
eurjchem-2534	5	6	received	receive	VERB
eurjchem-2534	5	7	:	:	PUNCT
eurjchem-2534	5	8	27	27	NUM
eurjchem-2534	5	9	february	february	NOUN
eurjchem-2534	5	10	2024	2024	NUM
eurjchem-2534	5	11	received	receive	VERB
eurjchem-2534	5	12	in	in	ADP
eurjchem-2534	5	13	revised	revise	VERB
eurjchem-2534	5	14	form	form	NOUN
eurjchem-2534	5	15	:	:	PUNCT
eurjchem-2534	5	16	3	3	NUM
eurjchem-2534	5	17	may	may	PROPN
eurjchem-2534	5	18	2024	2024	NUM
eurjchem-2534	5	19	accepted	accept	VERB
eurjchem-2534	5	20	:	:	PUNCT
eurjchem-2534	5	21	11	11	NUM
eurjchem-2534	5	22	may	may	AUX
eurjchem-2534	5	23	2024	2024	NUM
eurjchem-2534	5	24	published	publish	VERB
eurjchem-2534	5	25	online	online	ADV
eurjchem-2534	5	26	:	:	PUNCT
eurjchem-2534	5	27	30	30	NUM
eurjchem-2534	5	28	june	june	PROPN
eurjchem-2534	5	29	2024	2024	NUM
eurjchem-2534	5	30	printed	print	VERB
eurjchem-2534	5	31	:	:	PUNCT
eurjchem-2534	5	32	30	30	NUM
eurjchem-2534	5	33	june	june	PROPN
eurjchem-2534	5	34	2024	2024	NUM
eurjchem-2534	5	35	tripterygium	tripterygium	NOUN
eurjchem-2534	5	36	wilfordii	wilfordii	NOUN
eurjchem-2534	5	37	(	(	PUNCT
eurjchem-2534	5	38	trwi	trwi	NOUN
eurjchem-2534	5	39	)	)	PUNCT
eurjchem-2534	5	40	,	,	PUNCT
eurjchem-2534	5	41	known	know	VERB
eurjchem-2534	5	42	as	as	ADP
eurjchem-2534	5	43	'	'	PUNCT
eurjchem-2534	5	44	thunder	thunder	NOUN
eurjchem-2534	5	45	of	of	ADP
eurjchem-2534	5	46	god	god	PROPN
eurjchem-2534	5	47	vine	vine	NOUN
eurjchem-2534	5	48	'	'	PUNCT
eurjchem-2534	5	49	or	or	CCONJ
eurjchem-2534	5	50	'	'	PUNCT
eurjchem-2534	5	51	lei	lei	X
eurjchem-2534	5	52	gong	gong	NOUN
eurjchem-2534	5	53	teng	teng	PROPN
eurjchem-2534	5	54	'	'	PUNCT
eurjchem-2534	5	55	in	in	ADP
eurjchem-2534	5	56	traditional	traditional	ADJ
eurjchem-2534	5	57	chinese	chinese	ADJ
eurjchem-2534	5	58	medicine	medicine	NOUN
eurjchem-2534	5	59	(	(	PUNCT
eurjchem-2534	5	60	tcm	tcm	PROPN
eurjchem-2534	5	61	)	)	PUNCT
eurjchem-2534	5	62	,	,	PUNCT
eurjchem-2534	5	63	is	be	AUX
eurjchem-2534	5	64	a	a	DET
eurjchem-2534	5	65	perennial	perennial	ADJ
eurjchem-2534	5	66	vine	vine	NOUN
eurjchem-2534	5	67	that	that	PRON
eurjchem-2534	5	68	has	have	AUX
eurjchem-2534	5	69	been	be	AUX
eurjchem-2534	5	70	used	use	VERB
eurjchem-2534	5	71	for	for	ADP
eurjchem-2534	5	72	centuries	century	NOUN
eurjchem-2534	5	73	for	for	ADP
eurjchem-2534	5	74	its	its	PRON
eurjchem-2534	5	75	potent	potent	ADJ
eurjchem-2534	5	76	therapeutic	therapeutic	ADJ
eurjchem-2534	5	77	properties	property	NOUN
eurjchem-2534	5	78	.	.	PUNCT
eurjchem-2534	6	1	this	this	DET
eurjchem-2534	6	2	plant	plant	NOUN
eurjchem-2534	6	3	,	,	PUNCT
eurjchem-2534	6	4	which	which	PRON
eurjchem-2534	6	5	belongs	belong	VERB
eurjchem-2534	6	6	to	to	ADP
eurjchem-2534	6	7	the	the	DET
eurjchem-2534	6	8	celastraceae	celastraceae	PROPN
eurjchem-2534	6	9	family	family	NOUN
eurjchem-2534	6	10	,	,	PUNCT
eurjchem-2534	6	11	has	have	AUX
eurjchem-2534	6	12	been	be	AUX
eurjchem-2534	6	13	documented	document	VERB
eurjchem-2534	6	14	in	in	ADP
eurjchem-2534	6	15	various	various	ADJ
eurjchem-2534	6	16	tcm	tcm	PROPN
eurjchem-2534	6	17	texts	text	NOUN
eurjchem-2534	6	18	,	,	PUNCT
eurjchem-2534	6	19	where	where	SCONJ
eurjchem-2534	6	20	it	it	PRON
eurjchem-2534	6	21	has	have	AUX
eurjchem-2534	6	22	been	be	AUX
eurjchem-2534	6	23	attributed	attribute	VERB
eurjchem-2534	6	24	with	with	ADP
eurjchem-2534	6	25	a	a	DET
eurjchem-2534	6	26	wide	wide	ADJ
eurjchem-2534	6	27	range	range	NOUN
eurjchem-2534	6	28	of	of	ADP
eurjchem-2534	6	29	benefits	benefit	NOUN
eurjchem-2534	6	30	,	,	PUNCT
eurjchem-2534	6	31	including	include	VERB
eurjchem-2534	6	32	anti	anti	ADJ
eurjchem-2534	6	33	-	-	ADJ
eurjchem-2534	6	34	inflammatory	inflammatory	ADJ
eurjchem-2534	6	35	,	,	PUNCT
eurjchem-2534	6	36	antirheumatic	antirheumatic	ADJ
eurjchem-2534	6	37	,	,	PUNCT
eurjchem-2534	6	38	and	and	CCONJ
eurjchem-2534	6	39	anti	anti	ADJ
eurjchem-2534	6	40	-	-	ADJ
eurjchem-2534	6	41	autoimmune	autoimmune	ADJ
eurjchem-2534	6	42	activities	activity	NOUN
eurjchem-2534	6	43	.	.	PUNCT
eurjchem-2534	7	1	central	central	ADJ
eurjchem-2534	7	2	to	to	ADP
eurjchem-2534	7	3	the	the	DET
eurjchem-2534	7	4	medicinal	medicinal	ADJ
eurjchem-2534	7	5	potential	potential	NOUN
eurjchem-2534	7	6	of	of	ADP
eurjchem-2534	7	7	trwi	trwi	NOUN
eurjchem-2534	7	8	is	be	AUX
eurjchem-2534	7	9	celastrol	celastrol	NOUN
eurjchem-2534	7	10	,	,	PUNCT
eurjchem-2534	7	11	a	a	DET
eurjchem-2534	7	12	triterpenoid	triterpenoid	NOUN
eurjchem-2534	7	13	with	with	ADP
eurjchem-2534	7	14	extensive	extensive	ADJ
eurjchem-2534	7	15	pharmacological	pharmacological	ADJ
eurjchem-2534	7	16	activities	activity	NOUN
eurjchem-2534	7	17	.	.	PUNCT
eurjchem-2534	8	1	research	research	NOUN
eurjchem-2534	8	2	on	on	ADP
eurjchem-2534	8	3	celastrol	celastrol	NOUN
eurjchem-2534	8	4	has	have	AUX
eurjchem-2534	8	5	revealed	reveal	VERB
eurjchem-2534	8	6	its	its	PRON
eurjchem-2534	8	7	effects	effect	NOUN
eurjchem-2534	8	8	on	on	ADP
eurjchem-2534	8	9	combating	combat	VERB
eurjchem-2534	8	10	inflammation	inflammation	NOUN
eurjchem-2534	8	11	,	,	PUNCT
eurjchem-2534	8	12	oxidative	oxidative	ADJ
eurjchem-2534	8	13	stress	stress	NOUN
eurjchem-2534	8	14	,	,	PUNCT
eurjchem-2534	8	15	cancer	cancer	NOUN
eurjchem-2534	8	16	proliferation	proliferation	NOUN
eurjchem-2534	8	17	,	,	PUNCT
eurjchem-2534	8	18	and	and	CCONJ
eurjchem-2534	8	19	neurological	neurological	ADJ
eurjchem-2534	8	20	disorders	disorder	NOUN
eurjchem-2534	8	21	.	.	PUNCT
eurjchem-2534	9	1	however	however	ADV
eurjchem-2534	9	2	,	,	PUNCT
eurjchem-2534	9	3	celastrol	celastrol	PROPN
eurjchem-2534	9	4	’s	’s	PART
eurjchem-2534	9	5	high	high	ADJ
eurjchem-2534	9	6	toxicity	toxicity	NOUN
eurjchem-2534	9	7	,	,	PUNCT
eurjchem-2534	9	8	low	low	ADJ
eurjchem-2534	9	9	water	water	NOUN
eurjchem-2534	9	10	solubility	solubility	NOUN
eurjchem-2534	9	11	,	,	PUNCT
eurjchem-2534	9	12	and	and	CCONJ
eurjchem-2534	9	13	limited	limited	ADJ
eurjchem-2534	9	14	stability	stability	NOUN
eurjchem-2534	9	15	pose	pose	VERB
eurjchem-2534	9	16	challenges	challenge	NOUN
eurjchem-2534	9	17	for	for	ADP
eurjchem-2534	9	18	its	its	PRON
eurjchem-2534	9	19	clinical	clinical	ADJ
eurjchem-2534	9	20	application	application	NOUN
eurjchem-2534	9	21	.	.	PUNCT
eurjchem-2534	10	1	in	in	ADP
eurjchem-2534	10	2	this	this	DET
eurjchem-2534	10	3	review	review	NOUN
eurjchem-2534	10	4	,	,	PUNCT
eurjchem-2534	10	5	we	we	PRON
eurjchem-2534	10	6	explore	explore	VERB
eurjchem-2534	10	7	the	the	DET
eurjchem-2534	10	8	chemical	chemical	ADJ
eurjchem-2534	10	9	structure	structure	NOUN
eurjchem-2534	10	10	of	of	ADP
eurjchem-2534	10	11	celastrol	celastrol	NOUN
eurjchem-2534	10	12	,	,	PUNCT
eurjchem-2534	10	13	emphasizing	emphasize	VERB
eurjchem-2534	10	14	its	its	PRON
eurjchem-2534	10	15	key	key	ADJ
eurjchem-2534	10	16	pharmacological	pharmacological	NOUN
eurjchem-2534	10	17	activities	activity	NOUN
eurjchem-2534	10	18	and	and	CCONJ
eurjchem-2534	10	19	the	the	DET
eurjchem-2534	10	20	structure	structure	NOUN
eurjchem-2534	10	21	-	-	PUNCT
eurjchem-2534	10	22	activity	activity	NOUN
eurjchem-2534	10	23	relationships	relationship	NOUN
eurjchem-2534	10	24	(	(	PUNCT
eurjchem-2534	10	25	sars	sar	NOUN
eurjchem-2534	10	26	)	)	PUNCT
eurjchem-2534	10	27	that	that	PRON
eurjchem-2534	10	28	influence	influence	VERB
eurjchem-2534	10	29	its	its	PRON
eurjchem-2534	10	30	efficacy	efficacy	NOUN
eurjchem-2534	10	31	and	and	CCONJ
eurjchem-2534	10	32	toxicity	toxicity	NOUN
eurjchem-2534	10	33	.	.	PUNCT
eurjchem-2534	11	1	various	various	ADJ
eurjchem-2534	11	2	studies	study	NOUN
eurjchem-2534	11	3	have	have	AUX
eurjchem-2534	11	4	demonstrated	demonstrate	VERB
eurjchem-2534	11	5	that	that	SCONJ
eurjchem-2534	11	6	modifications	modification	NOUN
eurjchem-2534	11	7	at	at	ADP
eurjchem-2534	11	8	specific	specific	ADJ
eurjchem-2534	11	9	sites	site	NOUN
eurjchem-2534	11	10	,	,	PUNCT
eurjchem-2534	11	11	such	such	ADJ
eurjchem-2534	11	12	as	as	ADP
eurjchem-2534	11	13	the	the	DET
eurjchem-2534	11	14	c-29	c-29	PUNCT
eurjchem-2534	11	15	carboxylic	carboxylic	ADJ
eurjchem-2534	11	16	group	group	NOUN
eurjchem-2534	11	17	,	,	PUNCT
eurjchem-2534	11	18	c-6	c-6	PROPN
eurjchem-2534	11	19	,	,	PUNCT
eurjchem-2534	11	20	and	and	CCONJ
eurjchem-2534	11	21	c-3	c-3	PROPN
eurjchem-2534	11	22	,	,	PUNCT
eurjchem-2534	11	23	can	can	AUX
eurjchem-2534	11	24	enhance	enhance	VERB
eurjchem-2534	11	25	celastrol	celastrol	PROPN
eurjchem-2534	11	26	’s	’s	PART
eurjchem-2534	11	27	therapeutic	therapeutic	ADJ
eurjchem-2534	11	28	potential	potential	NOUN
eurjchem-2534	11	29	while	while	SCONJ
eurjchem-2534	11	30	reducing	reduce	VERB
eurjchem-2534	11	31	adverse	adverse	ADJ
eurjchem-2534	11	32	effects	effect	NOUN
eurjchem-2534	11	33	.	.	PUNCT
eurjchem-2534	12	1	moreover	moreover	ADV
eurjchem-2534	12	2	,	,	PUNCT
eurjchem-2534	12	3	recent	recent	ADJ
eurjchem-2534	12	4	advances	advance	NOUN
eurjchem-2534	12	5	in	in	ADP
eurjchem-2534	12	6	drug	drug	NOUN
eurjchem-2534	12	7	delivery	delivery	NOUN
eurjchem-2534	12	8	systems	system	NOUN
eurjchem-2534	12	9	offer	offer	VERB
eurjchem-2534	12	10	promising	promise	VERB
eurjchem-2534	12	11	avenues	avenue	NOUN
eurjchem-2534	12	12	to	to	PART
eurjchem-2534	12	13	overcome	overcome	VERB
eurjchem-2534	12	14	the	the	DET
eurjchem-2534	12	15	inherent	inherent	ADJ
eurjchem-2534	12	16	limitations	limitation	NOUN
eurjchem-2534	12	17	of	of	ADP
eurjchem-2534	12	18	celastrol	celastrol	NOUN
eurjchem-2534	12	19	.	.	PUNCT
eurjchem-2534	13	1	these	these	PRON
eurjchem-2534	13	2	include	include	VERB
eurjchem-2534	13	3	direct	direct	ADJ
eurjchem-2534	13	4	modifications	modification	NOUN
eurjchem-2534	13	5	such	such	ADJ
eurjchem-2534	13	6	as	as	ADP
eurjchem-2534	13	7	pegylation	pegylation	NOUN
eurjchem-2534	13	8	and	and	CCONJ
eurjchem-2534	13	9	indirect	indirect	ADJ
eurjchem-2534	13	10	modifications	modification	NOUN
eurjchem-2534	13	11	through	through	ADP
eurjchem-2534	13	12	encapsulation	encapsulation	NOUN
eurjchem-2534	13	13	in	in	ADP
eurjchem-2534	13	14	dendritic	dendritic	ADJ
eurjchem-2534	13	15	polymers	polymer	NOUN
eurjchem-2534	13	16	,	,	PUNCT
eurjchem-2534	13	17	phytosomes	phytosome	NOUN
eurjchem-2534	13	18	,	,	PUNCT
eurjchem-2534	13	19	liposomes	liposome	NOUN
eurjchem-2534	13	20	,	,	PUNCT
eurjchem-2534	13	21	and	and	CCONJ
eurjchem-2534	13	22	exosomes	exosome	NOUN
eurjchem-2534	13	23	.	.	PUNCT
eurjchem-2534	14	1	each	each	DET
eurjchem-2534	14	2	method	method	NOUN
eurjchem-2534	14	3	seeks	seek	VERB
eurjchem-2534	14	4	to	to	PART
eurjchem-2534	14	5	improve	improve	VERB
eurjchem-2534	14	6	celastrol	celastrol	NOUN
eurjchem-2534	14	7	bioavailability	bioavailability	NOUN
eurjchem-2534	14	8	,	,	PUNCT
eurjchem-2534	14	9	water	water	NOUN
eurjchem-2534	14	10	solubility	solubility	NOUN
eurjchem-2534	14	11	,	,	PUNCT
eurjchem-2534	14	12	and	and	CCONJ
eurjchem-2534	14	13	target	target	VERB
eurjchem-2534	14	14	capabilities	capability	NOUN
eurjchem-2534	14	15	,	,	PUNCT
eurjchem-2534	14	16	thus	thus	ADV
eurjchem-2534	14	17	enhancing	enhance	VERB
eurjchem-2534	14	18	its	its	PRON
eurjchem-2534	14	19	clinical	clinical	ADJ
eurjchem-2534	14	20	viability	viability	NOUN
eurjchem-2534	14	21	.	.	PUNCT
eurjchem-2534	15	1	the	the	DET
eurjchem-2534	15	2	objective	objective	NOUN
eurjchem-2534	15	3	of	of	ADP
eurjchem-2534	15	4	this	this	DET
eurjchem-2534	15	5	review	review	NOUN
eurjchem-2534	15	6	is	be	AUX
eurjchem-2534	15	7	to	to	PART
eurjchem-2534	15	8	synthesize	synthesize	VERB
eurjchem-2534	15	9	current	current	ADJ
eurjchem-2534	15	10	knowledge	knowledge	NOUN
eurjchem-2534	15	11	about	about	ADP
eurjchem-2534	15	12	celastrol	celastrol	PROPN
eurjchem-2534	15	13	’s	’s	PART
eurjchem-2534	15	14	therapeutic	therapeutic	ADJ
eurjchem-2534	15	15	potential	potential	NOUN
eurjchem-2534	15	16	and	and	CCONJ
eurjchem-2534	15	17	discuss	discuss	VERB
eurjchem-2534	15	18	the	the	DET
eurjchem-2534	15	19	future	future	NOUN
eurjchem-2534	15	20	of	of	ADP
eurjchem-2534	15	21	its	its	PRON
eurjchem-2534	15	22	development	development	NOUN
eurjchem-2534	15	23	in	in	ADP
eurjchem-2534	15	24	drug	drug	NOUN
eurjchem-2534	15	25	delivery	delivery	NOUN
eurjchem-2534	15	26	and	and	CCONJ
eurjchem-2534	15	27	pharmaceutical	pharmaceutical	NOUN
eurjchem-2534	15	28	applications	application	NOUN
eurjchem-2534	15	29	.	.	PUNCT
eurjchem-2534	16	1	these	these	DET
eurjchem-2534	16	2	findings	finding	NOUN
eurjchem-2534	16	3	could	could	AUX
eurjchem-2534	16	4	open	open	VERB
eurjchem-2534	16	5	the	the	DET
eurjchem-2534	16	6	door	door	NOUN
eurjchem-2534	16	7	to	to	ADP
eurjchem-2534	16	8	new	new	ADJ
eurjchem-2534	16	9	treatment	treatment	NOUN
eurjchem-2534	16	10	methods	method	NOUN
eurjchem-2534	16	11	that	that	PRON
eurjchem-2534	16	12	combine	combine	VERB
eurjchem-2534	16	13	traditional	traditional	ADJ
eurjchem-2534	16	14	remedies	remedy	NOUN
eurjchem-2534	16	15	with	with	ADP
eurjchem-2534	16	16	modern	modern	ADJ
eurjchem-2534	16	17	pharmacology	pharmacology	NOUN
eurjchem-2534	16	18	,	,	PUNCT
eurjchem-2534	16	19	helping	help	VERB
eurjchem-2534	16	20	us	we	PRON
eurjchem-2534	16	21	unlock	unlock	VERB
eurjchem-2534	16	22	the	the	DET
eurjchem-2534	16	23	complete	complete	ADJ
eurjchem-2534	16	24	potential	potential	NOUN
eurjchem-2534	16	25	of	of	ADP
eurjchem-2534	16	26	celastrol	celastrol	NOUN
eurjchem-2534	16	27	in	in	ADP
eurjchem-2534	16	28	clinical	clinical	ADJ
eurjchem-2534	16	29	use	use	NOUN
eurjchem-2534	16	30	.	.	PUNCT
eurjchem-2534	17	1	celastrol	celastrol	NOUN
eurjchem-2534	17	2	antioxidant	antioxidant	PROPN
eurjchem-2534	17	3	triterpenoids	triterpenoids	PROPN
eurjchem-2534	17	4	drug	drug	NOUN
eurjchem-2534	17	5	discovery	discovery	PROPN
eurjchem-2534	17	6	medicinal	medicinal	ADJ
eurjchem-2534	17	7	chemistry	chemistry	PROPN
eurjchem-2534	17	8	traditional	traditional	ADJ
eurjchem-2534	17	9	chinese	chinese	ADJ
eurjchem-2534	17	10	medicine	medicine	NOUN
eurjchem-2534	17	11	(	(	PUNCT
eurjchem-2534	17	12	tcm	tcm	PROPN
eurjchem-2534	17	13	)	)	PUNCT
eurjchem-2534	17	14	cite	cite	VERB
eurjchem-2534	17	15	this	this	PRON
eurjchem-2534	17	16	:	:	PUNCT
eurjchem-2534	17	17	eur	eur	PROPN
eurjchem-2534	17	18	.	.	PUNCT
eurjchem-2534	18	1	j.	j.	PROPN
eurjchem-2534	18	2	chem	chem	PROPN
eurjchem-2534	18	3	.	.	PUNCT
eurjchem-2534	19	1	2024	2024	NUM
eurjchem-2534	19	2	,	,	PUNCT
eurjchem-2534	19	3	15(2	15(2	NUM
eurjchem-2534	19	4	)	)	PUNCT
eurjchem-2534	19	5	,	,	PUNCT
eurjchem-2534	19	6	194	194	NUM
eurjchem-2534	19	7	-	-	SYM
eurjchem-2534	19	8	204	204	NUM
eurjchem-2534	19	9	journal	journal	NOUN
eurjchem-2534	19	10	website	website	NOUN
eurjchem-2534	19	11	:	:	PUNCT
eurjchem-2534	19	12	www.eurjchem.com	www.eurjchem.com	X
eurjchem-2534	19	13	1	1	X
eurjchem-2534	19	14	.	.	PUNCT
eurjchem-2534	19	15	introduction	introduction	NOUN
eurjchem-2534	19	16	tripterygium	tripterygium	NOUN
eurjchem-2534	19	17	wilfordii	wilfordii	PROPN
eurjchem-2534	19	18	hook	hook	NOUN
eurjchem-2534	19	19	f.	f.	PROPN
eurjchem-2534	19	20	(	(	PUNCT
eurjchem-2534	19	21	ncbi	ncbi	NOUN
eurjchem-2534	19	22	:	:	PUNCT
eurjchem-2534	19	23	txid458696	txid458696	NOUN
eurjchem-2534	19	24	)	)	PUNCT
eurjchem-2534	19	25	(	(	PUNCT
eurjchem-2534	19	26	trwi	trwi	NOUN
eurjchem-2534	19	27	)	)	PUNCT
eurjchem-2534	19	28	,	,	PUNCT
eurjchem-2534	19	29	commonly	commonly	ADV
eurjchem-2534	19	30	known	know	VERB
eurjchem-2534	19	31	as	as	ADP
eurjchem-2534	19	32	'	'	PUNCT
eurjchem-2534	19	33	thunder	thunder	NOUN
eurjchem-2534	19	34	of	of	ADP
eurjchem-2534	19	35	god	god	PROPN
eurjchem-2534	19	36	vine	vine	NOUN
eurjchem-2534	19	37	'	'	PUNCT
eurjchem-2534	19	38	or	or	CCONJ
eurjchem-2534	19	39	'	'	PUNCT
eurjchem-2534	19	40	lei	lei	X
eurjchem-2534	19	41	gong	gong	NOUN
eurjchem-2534	19	42	teng	teng	PROPN
eurjchem-2534	19	43	'	'	PUNCT
eurjchem-2534	19	44	in	in	ADP
eurjchem-2534	19	45	chinese	chinese	PROPN
eurjchem-2534	19	46	,	,	PUNCT
eurjchem-2534	19	47	has	have	AUX
eurjchem-2534	19	48	long	long	ADV
eurjchem-2534	19	49	been	be	AUX
eurjchem-2534	19	50	valued	value	VERB
eurjchem-2534	19	51	in	in	ADP
eurjchem-2534	19	52	traditional	traditional	ADJ
eurjchem-2534	19	53	chinese	chinese	ADJ
eurjchem-2534	19	54	medicine	medicine	NOUN
eurjchem-2534	19	55	(	(	PUNCT
eurjchem-2534	19	56	tcm	tcm	PROPN
eurjchem-2534	19	57	)	)	PUNCT
eurjchem-2534	20	1	[	[	X
eurjchem-2534	20	2	1	1	NUM
eurjchem-2534	20	3	]	]	PUNCT
eurjchem-2534	20	4	.	.	PUNCT
eurjchem-2534	21	1	this	this	DET
eurjchem-2534	21	2	perennial	perennial	ADJ
eurjchem-2534	21	3	vine	vine	NOUN
eurjchem-2534	21	4	of	of	ADP
eurjchem-2534	21	5	the	the	DET
eurjchem-2534	21	6	genus	genus	ADJ
eurjchem-2534	21	7	tripterygium	tripterygium	NOUN
eurjchem-2534	21	8	of	of	ADP
eurjchem-2534	21	9	the	the	DET
eurjchem-2534	21	10	family	family	NOUN
eurjchem-2534	21	11	celastraceae	celastraceae	NOUN
eurjchem-2534	21	12	has	have	AUX
eurjchem-2534	21	13	been	be	AUX
eurjchem-2534	21	14	a	a	DET
eurjchem-2534	21	15	staple	staple	NOUN
eurjchem-2534	21	16	of	of	ADP
eurjchem-2534	21	17	traditional	traditional	ADJ
eurjchem-2534	21	18	chinese	chinese	ADJ
eurjchem-2534	21	19	medicine	medicine	NOUN
eurjchem-2534	21	20	practices	practice	NOUN
eurjchem-2534	21	21	for	for	ADP
eurjchem-2534	21	22	centuries	century	NOUN
eurjchem-2534	21	23	.	.	PUNCT
eurjchem-2534	22	1	its	its	PRON
eurjchem-2534	22	2	therapeutic	therapeutic	ADJ
eurjchem-2534	22	3	properties	property	NOUN
eurjchem-2534	22	4	,	,	PUNCT
eurjchem-2534	22	5	deeply	deeply	ADV
eurjchem-2534	22	6	rooted	root	VERB
eurjchem-2534	22	7	in	in	ADP
eurjchem-2534	22	8	ancient	ancient	ADJ
eurjchem-2534	22	9	wisdom	wisdom	NOUN
eurjchem-2534	22	10	,	,	PUNCT
eurjchem-2534	22	11	span	span	VERB
eurjchem-2534	22	12	a	a	DET
eurjchem-2534	22	13	wide	wide	ADJ
eurjchem-2534	22	14	spectrum	spectrum	NOUN
eurjchem-2534	22	15	of	of	ADP
eurjchem-2534	22	16	applications	application	NOUN
eurjchem-2534	22	17	.	.	PUNCT
eurjchem-2534	23	1	trwi	trwi	NOUN
eurjchem-2534	23	2	is	be	AUX
eurjchem-2534	23	3	traditionally	traditionally	ADV
eurjchem-2534	23	4	recognized	recognize	VERB
eurjchem-2534	23	5	for	for	ADP
eurjchem-2534	23	6	its	its	PRON
eurjchem-2534	23	7	antiinflammatory	antiinflammatory	NOUN
eurjchem-2534	23	8	and	and	CCONJ
eurjchem-2534	23	9	anti	anti	ADJ
eurjchem-2534	23	10	-	-	ADJ
eurjchem-2534	23	11	autoimmune	autoimmune	ADJ
eurjchem-2534	23	12	benefits	benefit	NOUN
eurjchem-2534	23	13	and	and	CCONJ
eurjchem-2534	23	14	its	its	PRON
eurjchem-2534	23	15	efficacy	efficacy	NOUN
eurjchem-2534	23	16	in	in	ADP
eurjchem-2534	23	17	the	the	DET
eurjchem-2534	23	18	treatment	treatment	NOUN
eurjchem-2534	23	19	of	of	ADP
eurjchem-2534	23	20	rheumatism	rheumatism	NOUN
eurjchem-2534	23	21	,	,	PUNCT
eurjchem-2534	23	22	cancer	cancer	NOUN
eurjchem-2534	23	23	,	,	PUNCT
eurjchem-2534	23	24	and	and	CCONJ
eurjchem-2534	23	25	skin	skin	NOUN
eurjchem-2534	23	26	disorders	disorder	NOUN
eurjchem-2534	23	27	.	.	PUNCT
eurjchem-2534	24	1	the	the	DET
eurjchem-2534	24	2	first	first	ADJ
eurjchem-2534	24	3	documented	document	VERB
eurjchem-2534	24	4	use	use	NOUN
eurjchem-2534	24	5	of	of	ADP
eurjchem-2534	24	6	trwi	trwi	NOUN
eurjchem-2534	24	7	dates	date	VERB
eurjchem-2534	24	8	to	to	ADP
eurjchem-2534	24	9	the	the	DET
eurjchem-2534	24	10	south	south	PROPN
eurjchem-2534	24	11	yunnan	yunnan	PROPN
eurjchem-2534	24	12	materia	materia	PROPN
eurjchem-2534	24	13	medica	medica	PROPN
eurjchem-2534	24	14	in	in	ADP
eurjchem-2534	24	15	the	the	DET
eurjchem-2534	24	16	ming	ming	PROPN
eurjchem-2534	24	17	dynasty	dynasty	NOUN
eurjchem-2534	24	18	[	[	X
eurjchem-2534	24	19	2	2	NUM
eurjchem-2534	24	20	]	]	PUNCT
eurjchem-2534	24	21	.	.	PUNCT
eurjchem-2534	25	1	it	it	PRON
eurjchem-2534	25	2	has	have	AUX
eurjchem-2534	25	3	been	be	AUX
eurjchem-2534	25	4	noted	note	VERB
eurjchem-2534	25	5	for	for	ADP
eurjchem-2534	25	6	its	its	PRON
eurjchem-2534	25	7	ability	ability	NOUN
eurjchem-2534	25	8	to	to	PART
eurjchem-2534	25	9	“	"	PUNCT
eurjchem-2534	25	10	dispel	dispel	VERB
eurjchem-2534	25	11	pathogenic	pathogenic	ADJ
eurjchem-2534	25	12	wind	wind	NOUN
eurjchem-2534	25	13	"	"	PUNCT
eurjchem-2534	25	14	,	,	PUNCT
eurjchem-2534	25	15	"	"	PUNCT
eurjchem-2534	25	16	remove	remove	VERB
eurjchem-2534	25	17	dampness	dampness	NOUN
eurjchem-2534	25	18	"	"	PUNCT
eurjchem-2534	25	19	,	,	PUNCT
eurjchem-2534	25	20	and	and	CCONJ
eurjchem-2534	25	21	"	"	PUNCT
eurjchem-2534	25	22	promote	promote	VERB
eurjchem-2534	25	23	blood	blood	NOUN
eurjchem-2534	25	24	circulation	circulation	NOUN
eurjchem-2534	25	25	"	"	PUNCT
eurjchem-2534	25	26	.	.	PUNCT
eurjchem-2534	26	1	over	over	ADP
eurjchem-2534	26	2	the	the	DET
eurjchem-2534	26	3	centuries	century	NOUN
eurjchem-2534	26	4	,	,	PUNCT
eurjchem-2534	26	5	trwi	trwi	NOUN
eurjchem-2534	26	6	has	have	AUX
eurjchem-2534	26	7	been	be	AUX
eurjchem-2534	26	8	used	use	VERB
eurjchem-2534	26	9	to	to	PART
eurjchem-2534	26	10	address	address	VERB
eurjchem-2534	26	11	various	various	ADJ
eurjchem-2534	26	12	health	health	NOUN
eurjchem-2534	26	13	issues	issue	NOUN
eurjchem-2534	26	14	,	,	PUNCT
eurjchem-2534	26	15	due	due	ADP
eurjchem-2534	26	16	to	to	ADP
eurjchem-2534	26	17	its	its	PRON
eurjchem-2534	26	18	unique	unique	ADJ
eurjchem-2534	26	19	chemical	chemical	NOUN
eurjchem-2534	26	20	composition	composition	NOUN
eurjchem-2534	26	21	,	,	PUNCT
eurjchem-2534	26	22	including	include	VERB
eurjchem-2534	26	23	diterpenoids	diterpenoid	NOUN
eurjchem-2534	26	24	,	,	PUNCT
eurjchem-2534	26	25	triterpenoids	triterpenoids	PROPN
eurjchem-2534	26	26	,	,	PUNCT
eurjchem-2534	26	27	alkaloids	alkaloid	NOUN
eurjchem-2534	26	28	,	,	PUNCT
eurjchem-2534	26	29	and	and	CCONJ
eurjchem-2534	26	30	glycosides	glycoside	NOUN
eurjchem-2534	26	31	.	.	PUNCT
eurjchem-2534	27	1	contemporary	contemporary	ADJ
eurjchem-2534	27	2	research	research	NOUN
eurjchem-2534	27	3	has	have	AUX
eurjchem-2534	27	4	explored	explore	VERB
eurjchem-2534	27	5	its	its	PRON
eurjchem-2534	27	6	pharmacological	pharmacological	ADJ
eurjchem-2534	27	7	properties	property	NOUN
eurjchem-2534	27	8	in	in	ADP
eurjchem-2534	27	9	depth	depth	NOUN
eurjchem-2534	27	10	,	,	PUNCT
eurjchem-2534	27	11	revealing	reveal	VERB
eurjchem-2534	27	12	celastrol	celastrol	NOUN
eurjchem-2534	27	13	,	,	PUNCT
eurjchem-2534	27	14	a	a	DET
eurjchem-2534	27	15	powerful	powerful	ADJ
eurjchem-2534	27	16	triterpenoid	triterpenoid	NOUN
eurjchem-2534	27	17	with	with	ADP
eurjchem-2534	27	18	a	a	DET
eurjchem-2534	27	19	diverse	diverse	ADJ
eurjchem-2534	27	20	array	array	NOUN
eurjchem-2534	27	21	of	of	ADP
eurjchem-2534	27	22	health	health	NOUN
eurjchem-2534	27	23	benefits	benefit	NOUN
eurjchem-2534	27	24	.	.	PUNCT
eurjchem-2534	28	1	in	in	ADP
eurjchem-2534	28	2	recent	recent	ADJ
eurjchem-2534	28	3	years	year	NOUN
eurjchem-2534	28	4	,	,	PUNCT
eurjchem-2534	28	5	researchers	researcher	NOUN
eurjchem-2534	28	6	have	have	AUX
eurjchem-2534	28	7	focused	focus	VERB
eurjchem-2534	28	8	on	on	ADP
eurjchem-2534	28	9	bridging	bridge	VERB
eurjchem-2534	28	10	the	the	DET
eurjchem-2534	28	11	traditional	traditional	ADJ
eurjchem-2534	28	12	and	and	CCONJ
eurjchem-2534	28	13	modern	modern	ADJ
eurjchem-2534	28	14	aspects	aspect	NOUN
eurjchem-2534	28	15	of	of	ADP
eurjchem-2534	28	16	trwi	trwi	NOUN
eurjchem-2534	28	17	,	,	PUNCT
eurjchem-2534	28	18	exploring	explore	VERB
eurjchem-2534	28	19	its	its	PRON
eurjchem-2534	28	20	applications	application	NOUN
eurjchem-2534	28	21	in	in	ADP
eurjchem-2534	28	22	contemporary	contemporary	ADJ
eurjchem-2534	28	23	pharmacology	pharmacology	NOUN
eurjchem-2534	28	24	.	.	PUNCT
eurjchem-2534	29	1	exploring	explore	VERB
eurjchem-2534	29	2	the	the	DET
eurjchem-2534	29	3	therapeutic	therapeutic	ADJ
eurjchem-2534	29	4	potential	potential	NOUN
eurjchem-2534	29	5	of	of	ADP
eurjchem-2534	29	6	trwi	trwi	NOUN
eurjchem-2534	29	7	and	and	CCONJ
eurjchem-2534	29	8	celastrol	celastrol	NOUN
eurjchem-2534	29	9	offers	offer	VERB
eurjchem-2534	29	10	a	a	DET
eurjchem-2534	29	11	unique	unique	ADJ
eurjchem-2534	29	12	opportunity	opportunity	NOUN
eurjchem-2534	29	13	to	to	PART
eurjchem-2534	29	14	connect	connect	VERB
eurjchem-2534	29	15	ancient	ancient	ADJ
eurjchem-2534	29	16	healing	healing	NOUN
eurjchem-2534	29	17	methods	method	NOUN
eurjchem-2534	29	18	with	with	ADP
eurjchem-2534	29	19	modern	modern	ADJ
eurjchem-2534	29	20	medical	medical	ADJ
eurjchem-2534	29	21	advancements	advancement	NOUN
eurjchem-2534	29	22	.	.	PUNCT
eurjchem-2534	30	1	by	by	ADP
eurjchem-2534	30	2	investigating	investigate	VERB
eurjchem-2534	30	3	its	its	PRON
eurjchem-2534	30	4	mechanisms	mechanism	NOUN
eurjchem-2534	30	5	,	,	PUNCT
eurjchem-2534	30	6	safety	safety	NOUN
eurjchem-2534	30	7	profiles	profile	NOUN
eurjchem-2534	30	8	,	,	PUNCT
eurjchem-2534	30	9	and	and	CCONJ
eurjchem-2534	30	10	potential	potential	ADJ
eurjchem-2534	30	11	drug	drug	NOUN
eurjchem-2534	30	12	delivery	delivery	NOUN
eurjchem-2534	30	13	systems	system	NOUN
eurjchem-2534	30	14	,	,	PUNCT
eurjchem-2534	30	15	scientists	scientist	NOUN
eurjchem-2534	30	16	aim	aim	VERB
eurjchem-2534	30	17	to	to	PART
eurjchem-2534	30	18	unlock	unlock	VERB
eurjchem-2534	30	19	trwi	trwi	NOUN
eurjchem-2534	30	20	’s	’s	PART
eurjchem-2534	30	21	potential	potential	NOUN
eurjchem-2534	30	22	for	for	ADP
eurjchem-2534	30	23	clinical	clinical	ADJ
eurjchem-2534	30	24	use	use	NOUN
eurjchem-2534	30	25	in	in	ADP
eurjchem-2534	30	26	diverse	diverse	ADJ
eurjchem-2534	30	27	disease	disease	NOUN
eurjchem-2534	30	28	conditions	condition	NOUN
eurjchem-2534	30	29	.	.	PUNCT
eurjchem-2534	31	1	this	this	DET
eurjchem-2534	31	2	convergence	convergence	NOUN
eurjchem-2534	31	3	of	of	ADP
eurjchem-2534	31	4	traditional	traditional	ADJ
eurjchem-2534	31	5	medicine	medicine	NOUN
eurjchem-2534	31	6	and	and	CCONJ
eurjchem-2534	31	7	modern	modern	ADJ
eurjchem-2534	31	8	research	research	NOUN
eurjchem-2534	31	9	highlights	highlight	NOUN
eurjchem-2534	31	10	the	the	DET
eurjchem-2534	31	11	enduring	endure	VERB
eurjchem-2534	31	12	importance	importance	NOUN
eurjchem-2534	31	13	of	of	ADP
eurjchem-2534	31	14	trwi	trwi	NOUN
eurjchem-2534	31	15	and	and	CCONJ
eurjchem-2534	31	16	celastrol	celastrol	NOUN
eurjchem-2534	31	17	in	in	ADP
eurjchem-2534	31	18	the	the	DET
eurjchem-2534	31	19	current	current	ADJ
eurjchem-2534	31	20	medical	medical	ADJ
eurjchem-2534	31	21	field	field	NOUN
eurjchem-2534	31	22	.	.	PUNCT
eurjchem-2534	32	1	2	2	X
eurjchem-2534	32	2	.	.	X
eurjchem-2534	32	3	background	background	NOUN
eurjchem-2534	32	4	chemical	chemical	NOUN
eurjchem-2534	32	5	investigations	investigation	NOUN
eurjchem-2534	32	6	have	have	AUX
eurjchem-2534	32	7	revealed	reveal	VERB
eurjchem-2534	32	8	that	that	SCONJ
eurjchem-2534	32	9	the	the	DET
eurjchem-2534	32	10	complex	complex	ADJ
eurjchem-2534	32	11	components	component	NOUN
eurjchem-2534	32	12	of	of	ADP
eurjchem-2534	32	13	trwi	trwi	NOUN
eurjchem-2534	32	14	include	include	VERB
eurjchem-2534	32	15	diterpenoids	diterpenoid	NOUN
eurjchem-2534	32	16	,	,	PUNCT
eurjchem-2534	32	17	triterpenoids	triterpenoids	PROPN
eurjchem-2534	32	18	,	,	PUNCT
eurjchem-2534	32	19	alkaloids	alkaloid	NOUN
eurjchem-2534	32	20	,	,	PUNCT
eurjchem-2534	32	21	and	and	CCONJ
eurjchem-2534	32	22	some	some	DET
eurjchem-2534	32	23	glycosides	glycoside	NOUN
eurjchem-2534	32	24	.	.	PUNCT
eurjchem-2534	33	1	of	of	ADP
eurjchem-2534	33	2	these	these	PRON
eurjchem-2534	33	3	,	,	PUNCT
eurjchem-2534	33	4	celastrol	celastrol	NOUN
eurjchem-2534	33	5	(	(	PUNCT
eurjchem-2534	33	6	cel	cel	PROPN
eurjchem-2534	33	7	,	,	PUNCT
eurjchem-2534	33	8	1	1	NUM
eurjchem-2534	33	9	,	,	PUNCT
eurjchem-2534	33	10	figure	figure	NOUN
eurjchem-2534	33	11	1	1	NUM
eurjchem-2534	33	12	)	)	PUNCT
eurjchem-2534	33	13	,	,	PUNCT
eurjchem-2534	33	14	also	also	ADV
eurjchem-2534	33	15	known	know	VERB
eurjchem-2534	33	16	as	as	ADP
eurjchem-2534	33	17	tripterine	tripterine	ADJ
eurjchem-2534	33	18	,	,	PUNCT
eurjchem-2534	33	19	is	be	AUX
eurjchem-2534	33	20	a	a	DET
eurjchem-2534	33	21	water	water	NOUN
eurjchem-2534	33	22	-	-	PUNCT
eurjchem-2534	33	23	insoluble	insoluble	ADJ
eurjchem-2534	33	24	triterpenoid	triterpenoid	NOUN
eurjchem-2534	33	25	quinone	quinone	NOUN
eurjchem-2534	33	26	methide	methide	NOUN
eurjchem-2534	33	27	triterpene	triterpene	NOUN
eurjchem-2534	33	28	and	and	CCONJ
eurjchem-2534	33	29	the	the	DET
eurjchem-2534	33	30	main	main	ADJ
eurjchem-2534	33	31	active	active	ADJ
eurjchem-2534	33	32	principle	principle	NOUN
eurjchem-2534	33	33	of	of	ADP
eurjchem-2534	33	34	tripterygium	tripterygium	NOUN
eurjchem-2534	33	35	wilfordii	wilfordii	ADJ
eurjchem-2534	33	36	hook	hook	NOUN
eurjchem-2534	33	37	f.	f.	PROPN
eurjchem-2534	33	38	abstract	abstract	PROPN
eurjchem-2534	33	39	review	review	NOUN
eurjchem-2534	33	40	article	article	NOUN
eurjchem-2534	33	41	keywords	keyword	VERB
eurjchem-2534	33	42	https://dx.doi.org/10.5155/eurjchem.15.2.194-204.2534	https://dx.doi.org/10.5155/eurjchem.15.2.194-204.2534	NOUN
eurjchem-2534	33	43	https://www.eurjchem.com/	https://www.eurjchem.com/	ADJ
eurjchem-2534	33	44	https://dx.doi.org/10.5155/eurjchem.15.2.194-204.2534	https://dx.doi.org/10.5155/eurjchem.15.2.194-204.2534	ADJ
eurjchem-2534	33	45	mailto:coghips@must.edu.mo	mailto:coghips@must.edu.mo	NOUN
eurjchem-2534	33	46	http://www.eurjchem.com/	http://www.eurjchem.com/	NOUN
eurjchem-2534	33	47	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.15.2.194-204.2534&domain=pdf&date_stamp=2024-06-30	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.15.2.194-204.2534&domain=pdf&date_stamp=2024-06-30	NOUN
eurjchem-2534	33	48	ren	ren	PROPN
eurjchem-2534	33	49	and	and	CCONJ
eurjchem-2534	33	50	coghi	coghi	PROPN
eurjchem-2534	33	51	/	/	SYM
eurjchem-2534	33	52	european	european	PROPN
eurjchem-2534	33	53	journal	journal	PROPN
eurjchem-2534	33	54	of	of	ADP
eurjchem-2534	33	55	chemistry	chemistry	NOUN
eurjchem-2534	33	56	15	15	NUM
eurjchem-2534	33	57	(	(	PUNCT
eurjchem-2534	33	58	2	2	NUM
eurjchem-2534	33	59	)	)	PUNCT
eurjchem-2534	33	60	(	(	PUNCT
eurjchem-2534	33	61	2024	2024	NUM
eurjchem-2534	33	62	)	)	PUNCT
eurjchem-2534	33	63	194	194	NUM
eurjchem-2534	33	64	-	-	SYM
eurjchem-2534	33	65	204	204	NUM
eurjchem-2534	33	66	195	195	NUM
eurjchem-2534	33	67	2024	2024	NUM
eurjchem-2534	33	68	–	–	PUNCT
eurjchem-2534	33	69	european	european	ADJ
eurjchem-2534	33	70	journal	journal	NOUN
eurjchem-2534	33	71	of	of	ADP
eurjchem-2534	33	72	chemistry	chemistry	NOUN
eurjchem-2534	33	73	–	–	PUNCT
eurjchem-2534	33	74	cc	cc	NOUN
eurjchem-2534	33	75	by	by	ADP
eurjchem-2534	33	76	nc	nc	PROPN
eurjchem-2534	33	77	–	–	PUNCT
eurjchem-2534	33	78	doi	doi	PROPN
eurjchem-2534	33	79	:	:	PUNCT
eurjchem-2534	33	80	10.5155	10.5155	NUM
eurjchem-2534	33	81	/	/	SYM
eurjchem-2534	33	82	eurjchem.15.2.194	eurjchem.15.2.194	NOUN
eurjchem-2534	33	83	-	-	SYM
eurjchem-2534	33	84	204.2534	204.2534	NUM
eurjchem-2534	33	85	o	o	NOUN
eurjchem-2534	33	86	ho	ho	PROPN
eurjchem-2534	33	87	h	h	PROPN
eurjchem-2534	33	88	celastrol	celastrol	NOUN
eurjchem-2534	33	89	(	(	PUNCT
eurjchem-2534	33	90	1)1	1)1	NUM
eurjchem-2534	33	91	4	4	NUM
eurjchem-2534	33	92	6	6	NUM
eurjchem-2534	33	93	8	8	NUM
eurjchem-2534	33	94	20	20	NUM
eurjchem-2534	33	95	2	2	NUM
eurjchem-2534	33	96	3	3	NUM
eurjchem-2534	33	97	a	a	DET
eurjchem-2534	33	98	b	b	NOUN
eurjchem-2534	33	99	c	c	NOUN
eurjchem-2534	33	100	d	d	X
eurjchem-2534	33	101	e	e	X
eurjchem-2534	33	102	29	29	NUM
eurjchem-2534	34	1	oh	oh	INTJ
eurjchem-2534	34	2	o	o	INTJ
eurjchem-2534	34	3	o	o	X
eurjchem-2534	34	4	ho	ho	X
eurjchem-2534	34	5	h1	h1	PROPN
eurjchem-2534	34	6	4	4	NUM
eurjchem-2534	34	7	6	6	NUM
eurjchem-2534	34	8	8	8	NUM
eurjchem-2534	34	9	20	20	NUM
eurjchem-2534	34	10	2	2	NUM
eurjchem-2534	34	11	3	3	NUM
eurjchem-2534	34	12	a	a	DET
eurjchem-2534	34	13	b	b	NOUN
eurjchem-2534	34	14	c	c	NOUN
eurjchem-2534	34	15	d	d	X
eurjchem-2534	34	16	e	e	X
eurjchem-2534	34	17	29	29	NUM
eurjchem-2534	35	1	oh	oh	INTJ
eurjchem-2534	35	2	o	o	INTJ
eurjchem-2534	35	3	o	o	X
eurjchem-2534	36	1	ho	ho	PROPN
eurjchem-2534	36	2	h	h	PROPN
eurjchem-2534	36	3	4	4	NUM
eurjchem-2534	36	4	6	6	NUM
eurjchem-2534	36	5	8	8	NUM
eurjchem-2534	36	6	20	20	NUM
eurjchem-2534	36	7	3	3	NUM
eurjchem-2534	36	8	a	a	DET
eurjchem-2534	36	9	b	b	NOUN
eurjchem-2534	36	10	c	c	NOUN
eurjchem-2534	36	11	d	d	X
eurjchem-2534	36	12	e	e	X
eurjchem-2534	36	13	29	29	NUM
eurjchem-2534	37	1	oh	oh	INTJ
eurjchem-2534	37	2	o	o	INTJ
eurjchem-2534	37	3	h	h	NOUN
eurjchem-2534	38	1	cys	cys	PROPN
eurjchem-2534	38	2	sh	sh	PROPN
eurjchem-2534	38	3	ho	ho	PROPN
eurjchem-2534	38	4	ho	ho	PROPN
eurjchem-2534	38	5	h	h	PROPN
eurjchem-2534	38	6	4	4	NUM
eurjchem-2534	38	7	6	6	NUM
eurjchem-2534	38	8	8	8	NUM
eurjchem-2534	38	9	20	20	NUM
eurjchem-2534	38	10	3	3	NUM
eurjchem-2534	38	11	a	a	DET
eurjchem-2534	38	12	b	b	NOUN
eurjchem-2534	38	13	c	c	NOUN
eurjchem-2534	38	14	d	d	X
eurjchem-2534	38	15	e	e	X
eurjchem-2534	38	16	29	29	NUM
eurjchem-2534	39	1	oh	oh	INTJ
eurjchem-2534	39	2	o	o	INTJ
eurjchem-2534	39	3	h	h	NOUN
eurjchem-2534	39	4	s	s	PROPN
eurjchem-2534	39	5	cys	cys	X
eurjchem-2534	39	6	(	(	PUNCT
eurjchem-2534	39	7	a	a	NOUN
eurjchem-2534	39	8	)	)	PUNCT
eurjchem-2534	39	9	(	(	PUNCT
eurjchem-2534	39	10	b	b	X
eurjchem-2534	39	11	)	)	PUNCT
eurjchem-2534	39	12	figure	figure	NOUN
eurjchem-2534	39	13	1	1	NUM
eurjchem-2534	39	14	.	.	PUNCT
eurjchem-2534	40	1	(	(	PUNCT
eurjchem-2534	40	2	a	a	X
eurjchem-2534	40	3	)	)	PUNCT
eurjchem-2534	40	4	molecular	molecular	ADJ
eurjchem-2534	40	5	structure	structure	NOUN
eurjchem-2534	40	6	of	of	ADP
eurjchem-2534	40	7	compound	compound	NOUN
eurjchem-2534	40	8	1	1	NUM
eurjchem-2534	40	9	and	and	CCONJ
eurjchem-2534	40	10	(	(	PUNCT
eurjchem-2534	40	11	b	b	X
eurjchem-2534	40	12	)	)	PUNCT
eurjchem-2534	40	13	michael	michael	PROPN
eurjchem-2534	40	14	adducts	adduct	VERB
eurjchem-2534	40	15	interact	interact	ADV
eurjchem-2534	40	16	with	with	ADP
eurjchem-2534	40	17	the	the	DET
eurjchem-2534	40	18	biological	biological	ADJ
eurjchem-2534	40	19	target	target	NOUN
eurjchem-2534	40	20	.	.	PUNCT
eurjchem-2534	41	1	the	the	DET
eurjchem-2534	41	2	natural	natural	ADJ
eurjchem-2534	41	3	product	product	NOUN
eurjchem-2534	41	4	has	have	VERB
eurjchem-2534	41	5	a	a	DET
eurjchem-2534	41	6	wide	wide	ADJ
eurjchem-2534	41	7	range	range	NOUN
eurjchem-2534	41	8	of	of	ADP
eurjchem-2534	41	9	promising	promise	VERB
eurjchem-2534	41	10	pharmacological	pharmacological	NOUN
eurjchem-2534	41	11	activities	activity	NOUN
eurjchem-2534	41	12	relevant	relevant	ADJ
eurjchem-2534	41	13	to	to	ADP
eurjchem-2534	41	14	inflammation	inflammation	NOUN
eurjchem-2534	41	15	[	[	X
eurjchem-2534	41	16	3	3	NUM
eurjchem-2534	41	17	]	]	PUNCT
eurjchem-2534	41	18	,	,	PUNCT
eurjchem-2534	41	19	antioxidant	antioxidant	ADJ
eurjchem-2534	41	20	[	[	X
eurjchem-2534	41	21	4	4	NUM
eurjchem-2534	41	22	]	]	PUNCT
eurjchem-2534	41	23	,	,	PUNCT
eurjchem-2534	41	24	anti	anti	ADJ
eurjchem-2534	41	25	-	-	NOUN
eurjchem-2534	41	26	allergy	allergy	NOUN
eurjchem-2534	41	27	[	[	X
eurjchem-2534	41	28	5	5	NUM
eurjchem-2534	41	29	]	]	PUNCT
eurjchem-2534	41	30	,	,	PUNCT
eurjchem-2534	41	31	anti	anti	ADJ
eurjchem-2534	41	32	-	-	ADJ
eurjchem-2534	41	33	osteoarthritis	osteoarthritis	ADJ
eurjchem-2534	41	34	[	[	X
eurjchem-2534	41	35	6	6	NUM
eurjchem-2534	41	36	]	]	PUNCT
eurjchem-2534	41	37	,	,	PUNCT
eurjchem-2534	41	38	cardiac	cardiac	ADJ
eurjchem-2534	41	39	protection	protection	NOUN
eurjchem-2534	42	1	[	[	X
eurjchem-2534	42	2	7	7	NUM
eurjchem-2534	42	3	]	]	PUNCT
eurjchem-2534	42	4	,	,	PUNCT
eurjchem-2534	42	5	neuronal	neuronal	ADJ
eurjchem-2534	42	6	degeneration	degeneration	NOUN
eurjchem-2534	42	7	[	[	X
eurjchem-2534	42	8	8	8	NUM
eurjchem-2534	42	9	]	]	PUNCT
eurjchem-2534	42	10	,	,	PUNCT
eurjchem-2534	42	11	infectious	infectious	ADJ
eurjchem-2534	42	12	disease	disease	NOUN
eurjchem-2534	43	1	[	[	X
eurjchem-2534	43	2	9	9	NUM
eurjchem-2534	43	3	]	]	PUNCT
eurjchem-2534	43	4	and	and	CCONJ
eurjchem-2534	43	5	obesity	obesity	NOUN
eurjchem-2534	44	1	[	[	X
eurjchem-2534	44	2	10	10	NUM
eurjchem-2534	44	3	]	]	PUNCT
eurjchem-2534	44	4	.	.	PUNCT
eurjchem-2534	45	1	it	it	PRON
eurjchem-2534	45	2	has	have	AUX
eurjchem-2534	45	3	also	also	ADV
eurjchem-2534	45	4	been	be	AUX
eurjchem-2534	45	5	reported	report	VERB
eurjchem-2534	45	6	to	to	PART
eurjchem-2534	45	7	inhibit	inhibit	VERB
eurjchem-2534	45	8	cancer	cancer	NOUN
eurjchem-2534	45	9	cell	cell	NOUN
eurjchem-2534	45	10	growth	growth	NOUN
eurjchem-2534	46	1	[	[	X
eurjchem-2534	46	2	11	11	NUM
eurjchem-2534	46	3	]	]	PUNCT
eurjchem-2534	46	4	,	,	PUNCT
eurjchem-2534	46	5	induce	induce	VERB
eurjchem-2534	46	6	apoptosis	apoptosis	NOUN
eurjchem-2534	46	7	[	[	X
eurjchem-2534	46	8	12,13	12,13	NUM
eurjchem-2534	46	9	]	]	PUNCT
eurjchem-2534	46	10	,	,	PUNCT
eurjchem-2534	46	11	and	and	CCONJ
eurjchem-2534	46	12	suppress	suppress	VERB
eurjchem-2534	46	13	invasion	invasion	NOUN
eurjchem-2534	46	14	and	and	CCONJ
eurjchem-2534	46	15	metastasis	metastasis	NOUN
eurjchem-2534	46	16	of	of	ADP
eurjchem-2534	46	17	tumor	tumor	NOUN
eurjchem-2534	46	18	cells	cell	NOUN
eurjchem-2534	46	19	[	[	X
eurjchem-2534	46	20	14	14	NUM
eurjchem-2534	46	21	]	]	PUNCT
eurjchem-2534	46	22	.	.	PUNCT
eurjchem-2534	47	1	recently	recently	ADV
eurjchem-2534	47	2	,	,	PUNCT
eurjchem-2534	47	3	extensive	extensive	ADJ
eurjchem-2534	47	4	research	research	NOUN
eurjchem-2534	47	5	has	have	AUX
eurjchem-2534	47	6	indicated	indicate	VERB
eurjchem-2534	47	7	that	that	SCONJ
eurjchem-2534	47	8	cel	cel	PROPN
eurjchem-2534	47	9	manifests	manifest	VERB
eurjchem-2534	47	10	its	its	PRON
eurjchem-2534	47	11	pharmacological	pharmacological	ADJ
eurjchem-2534	47	12	functions	function	NOUN
eurjchem-2534	47	13	through	through	ADP
eurjchem-2534	47	14	several	several	ADJ
eurjchem-2534	47	15	molecular	molecular	ADJ
eurjchem-2534	47	16	targets	target	NOUN
eurjchem-2534	47	17	[	[	X
eurjchem-2534	47	18	15	15	NUM
eurjchem-2534	47	19	]	]	X
eurjchem-2534	47	20	,	,	PUNCT
eurjchem-2534	47	21	such	such	ADJ
eurjchem-2534	47	22	as	as	ADP
eurjchem-2534	47	23	serca	serca	NOUN
eurjchem-2534	47	24	,	,	PUNCT
eurjchem-2534	47	25	hsp90cdc37	hsp90cdc37	X
eurjchem-2534	48	1	[	[	X
eurjchem-2534	48	2	16	16	NUM
eurjchem-2534	48	3	]	]	PUNCT
eurjchem-2534	48	4	,	,	PUNCT
eurjchem-2534	48	5	nf	nf	PROPN
eurjchem-2534	48	6	-	-	PUNCT
eurjchem-2534	48	7	kb	kb	NOUN
eurjchem-2534	48	8	/	/	SYM
eurjchem-2534	48	9	ikkb	ikkb	NOUN
eurjchem-2534	49	1	[	[	X
eurjchem-2534	49	2	17	17	NUM
eurjchem-2534	49	3	]	]	PUNCT
eurjchem-2534	49	4	,	,	PUNCT
eurjchem-2534	49	5	the	the	DET
eurjchem-2534	49	6	vegfr1	vegfr1	NOUN
eurjchem-2534	49	7	,	,	PUNCT
eurjchem-2534	49	8	vegfr2	vegfr2	NOUN
eurjchem-2534	49	9	and	and	CCONJ
eurjchem-2534	49	10	pi3k	pi3k	PROPN
eurjchem-2534	49	11	/	/	SYM
eurjchem-2534	49	12	akt	akt	PROPN
eurjchem-2534	49	13	signaling	signal	VERB
eurjchem-2534	49	14	pathway	pathway	NOUN
eurjchem-2534	49	15	.	.	PUNCT
eurjchem-2534	50	1	previous	previous	ADJ
eurjchem-2534	50	2	studies	study	NOUN
eurjchem-2534	50	3	suggested	suggest	VERB
eurjchem-2534	50	4	that	that	SCONJ
eurjchem-2534	50	5	the	the	DET
eurjchem-2534	50	6	quinone	quinone	NOUN
eurjchem-2534	50	7	methide	methide	NOUN
eurjchem-2534	50	8	moiety	moiety	NOUN
eurjchem-2534	50	9	of	of	ADP
eurjchem-2534	50	10	celastrol	celastrol	NOUN
eurjchem-2534	50	11	was	be	AUX
eurjchem-2534	50	12	crucial	crucial	ADJ
eurjchem-2534	50	13	for	for	ADP
eurjchem-2534	50	14	its	its	PRON
eurjchem-2534	50	15	cytotoxic	cytotoxic	ADJ
eurjchem-2534	50	16	activity	activity	NOUN
eurjchem-2534	50	17	in	in	ADP
eurjchem-2534	50	18	cancer	cancer	NOUN
eurjchem-2534	50	19	cell	cell	NOUN
eurjchem-2534	50	20	lines	line	NOUN
eurjchem-2534	50	21	[	[	X
eurjchem-2534	50	22	18	18	NUM
eurjchem-2534	50	23	]	]	PUNCT
eurjchem-2534	50	24	.	.	PUNCT
eurjchem-2534	51	1	celastrol	celastrol	NOUN
eurjchem-2534	51	2	has	have	VERB
eurjchem-2534	51	3	electrophilic	electrophilic	ADJ
eurjchem-2534	51	4	sites	site	NOUN
eurjchem-2534	51	5	within	within	ADP
eurjchem-2534	51	6	the	the	DET
eurjchem-2534	51	7	a	a	PRON
eurjchem-2534	51	8	and	and	CCONJ
eurjchem-2534	51	9	b	b	NOUN
eurjchem-2534	51	10	rings	ring	NOUN
eurjchem-2534	51	11	,	,	PUNCT
eurjchem-2534	51	12	where	where	SCONJ
eurjchem-2534	51	13	nucleophilic	nucleophilic	ADJ
eurjchem-2534	51	14	groups	group	NOUN
eurjchem-2534	51	15	of	of	ADP
eurjchem-2534	51	16	amino	amino	NOUN
eurjchem-2534	51	17	acid	acid	NOUN
eurjchem-2534	51	18	residues	residue	NOUN
eurjchem-2534	51	19	react	react	VERB
eurjchem-2534	51	20	to	to	PART
eurjchem-2534	51	21	form	form	VERB
eurjchem-2534	51	22	covalent	covalent	NOUN
eurjchem-2534	51	23	michael	michael	PROPN
eurjchem-2534	51	24	adducts	adduct	VERB
eurjchem-2534	51	25	(	(	PUNCT
eurjchem-2534	51	26	figure	figure	NOUN
eurjchem-2534	51	27	1	1	NUM
eurjchem-2534	51	28	)	)	PUNCT
eurjchem-2534	51	29	.	.	PUNCT
eurjchem-2534	52	1	intracellular	intracellular	ADJ
eurjchem-2534	52	2	calcium	calcium	NOUN
eurjchem-2534	52	3	(	(	PUNCT
eurjchem-2534	52	4	ca2	ca2	PROPN
eurjchem-2534	52	5	+	+	NOUN
eurjchem-2534	52	6	)	)	PUNCT
eurjchem-2534	52	7	acts	act	VERB
eurjchem-2534	52	8	as	as	ADP
eurjchem-2534	52	9	a	a	DET
eurjchem-2534	52	10	second	second	ADJ
eurjchem-2534	52	11	messenger	messenger	NOUN
eurjchem-2534	52	12	,	,	PUNCT
eurjchem-2534	52	13	playing	play	VERB
eurjchem-2534	52	14	a	a	DET
eurjchem-2534	52	15	critical	critical	ADJ
eurjchem-2534	52	16	role	role	NOUN
eurjchem-2534	52	17	in	in	ADP
eurjchem-2534	52	18	regulating	regulate	VERB
eurjchem-2534	52	19	a	a	DET
eurjchem-2534	52	20	variety	variety	NOUN
eurjchem-2534	52	21	of	of	ADP
eurjchem-2534	52	22	cellular	cellular	ADJ
eurjchem-2534	52	23	processes	process	NOUN
eurjchem-2534	52	24	such	such	ADJ
eurjchem-2534	52	25	as	as	ADP
eurjchem-2534	52	26	gene	gene	NOUN
eurjchem-2534	52	27	transcription	transcription	NOUN
eurjchem-2534	52	28	,	,	PUNCT
eurjchem-2534	52	29	cell	cell	NOUN
eurjchem-2534	52	30	morphology	morphology	NOUN
eurjchem-2534	52	31	,	,	PUNCT
eurjchem-2534	52	32	motility	motility	NOUN
eurjchem-2534	52	33	,	,	PUNCT
eurjchem-2534	52	34	proliferation	proliferation	NOUN
eurjchem-2534	52	35	,	,	PUNCT
eurjchem-2534	52	36	mitochondrial	mitochondrial	ADJ
eurjchem-2534	52	37	function	function	NOUN
eurjchem-2534	52	38	,	,	PUNCT
eurjchem-2534	52	39	apoptosis	apoptosis	NOUN
eurjchem-2534	52	40	,	,	PUNCT
eurjchem-2534	52	41	and	and	CCONJ
eurjchem-2534	52	42	immune	immune	ADJ
eurjchem-2534	52	43	responses	response	NOUN
eurjchem-2534	52	44	[	[	X
eurjchem-2534	52	45	19	19	NUM
eurjchem-2534	52	46	]	]	PUNCT
eurjchem-2534	52	47	.	.	PUNCT
eurjchem-2534	53	1	two	two	NUM
eurjchem-2534	53	2	decades	decade	NOUN
eurjchem-2534	53	3	ago	ago	ADV
eurjchem-2534	53	4	,	,	PUNCT
eurjchem-2534	53	5	researchers	researcher	NOUN
eurjchem-2534	53	6	recognized	recognize	VERB
eurjchem-2534	53	7	the	the	DET
eurjchem-2534	53	8	significant	significant	ADJ
eurjchem-2534	53	9	role	role	NOUN
eurjchem-2534	53	10	ca2	ca2	PROPN
eurjchem-2534	53	11	+	+	PROPN
eurjchem-2534	53	12	plays	play	NOUN
eurjchem-2534	53	13	in	in	ADP
eurjchem-2534	53	14	various	various	ADJ
eurjchem-2534	53	15	diseases	disease	NOUN
eurjchem-2534	53	16	,	,	PUNCT
eurjchem-2534	53	17	including	include	VERB
eurjchem-2534	53	18	cardiovascular	cardiovascular	ADJ
eurjchem-2534	53	19	disease	disease	NOUN
eurjchem-2534	53	20	,	,	PUNCT
eurjchem-2534	53	21	stroke	stroke	NOUN
eurjchem-2534	53	22	,	,	PUNCT
eurjchem-2534	53	23	diabetes	diabetes	NOUN
eurjchem-2534	53	24	,	,	PUNCT
eurjchem-2534	53	25	immune	immune	ADJ
eurjchem-2534	53	26	responses	response	NOUN
eurjchem-2534	53	27	(	(	PUNCT
eurjchem-2534	53	28	like	like	ADP
eurjchem-2534	53	29	inflammation	inflammation	NOUN
eurjchem-2534	53	30	)	)	PUNCT
eurjchem-2534	53	31	,	,	PUNCT
eurjchem-2534	53	32	and	and	CCONJ
eurjchem-2534	53	33	cancer	cancer	NOUN
eurjchem-2534	53	34	[	[	X
eurjchem-2534	53	35	20	20	NUM
eurjchem-2534	53	36	]	]	PUNCT
eurjchem-2534	53	37	.	.	PUNCT
eurjchem-2534	54	1	ca2	ca2	PROPN
eurjchem-2534	54	2	+	+	PROPN
eurjchem-2534	54	3	has	have	VERB
eurjchem-2534	54	4	a	a	DET
eurjchem-2534	54	5	crucial	crucial	ADJ
eurjchem-2534	54	6	role	role	NOUN
eurjchem-2534	54	7	in	in	ADP
eurjchem-2534	54	8	autoimmunity	autoimmunity	NOUN
eurjchem-2534	54	9	and	and	CCONJ
eurjchem-2534	54	10	inherited	inherit	VERB
eurjchem-2534	54	11	immunological	immunological	ADJ
eurjchem-2534	54	12	disorders	disorder	NOUN
eurjchem-2534	54	13	.	.	PUNCT
eurjchem-2534	55	1	recent	recent	ADJ
eurjchem-2534	55	2	studies	study	NOUN
eurjchem-2534	55	3	indicate	indicate	VERB
eurjchem-2534	55	4	that	that	SCONJ
eurjchem-2534	55	5	intracellular	intracellular	ADJ
eurjchem-2534	55	6	ca2	ca2	NOUN
eurjchem-2534	55	7	+	+	NOUN
eurjchem-2534	55	8	signaling	signaling	NOUN
eurjchem-2534	55	9	is	be	AUX
eurjchem-2534	55	10	involved	involve	VERB
eurjchem-2534	55	11	in	in	ADP
eurjchem-2534	55	12	the	the	DET
eurjchem-2534	55	13	development	development	NOUN
eurjchem-2534	55	14	of	of	ADP
eurjchem-2534	55	15	autoimmune	autoimmune	ADJ
eurjchem-2534	55	16	diseases	disease	NOUN
eurjchem-2534	55	17	such	such	ADJ
eurjchem-2534	55	18	as	as	ADP
eurjchem-2534	55	19	lupus	lupus	ADJ
eurjchem-2534	55	20	erythematosus	erythematosus	NOUN
eurjchem-2534	55	21	and	and	CCONJ
eurjchem-2534	55	22	rheumatoid	rheumatoid	VERB
eurjchem-2534	55	23	arthritis	arthritis	NOUN
eurjchem-2534	55	24	(	(	PUNCT
eurjchem-2534	55	25	ra	ra	NOUN
eurjchem-2534	55	26	)	)	PUNCT
eurjchem-2534	56	1	[	[	X
eurjchem-2534	56	2	21	21	NUM
eurjchem-2534	56	3	]	]	PUNCT
eurjchem-2534	56	4	.	.	PUNCT
eurjchem-2534	57	1	celastrol	celastrol	PROPN
eurjchem-2534	57	2	has	have	AUX
eurjchem-2534	57	3	shown	show	VERB
eurjchem-2534	57	4	antiarthritic	antiarthritic	ADJ
eurjchem-2534	57	5	properties	property	NOUN
eurjchem-2534	57	6	in	in	ADP
eurjchem-2534	57	7	rheumatoid	rheumatoid	NOUN
eurjchem-2534	57	8	arthritis	arthritis	NOUN
eurjchem-2534	57	9	(	(	PUNCT
eurjchem-2534	57	10	ra	ra	NOUN
eurjchem-2534	57	11	)	)	PUNCT
eurjchem-2534	57	12	,	,	PUNCT
eurjchem-2534	57	13	but	but	CCONJ
eurjchem-2534	57	14	its	its	PRON
eurjchem-2534	57	15	role	role	NOUN
eurjchem-2534	57	16	in	in	ADP
eurjchem-2534	57	17	ca2	ca2	PROPN
eurjchem-2534	57	18	+	+	PROPN
eurjchem-2534	57	19	mobilization	mobilization	NOUN
eurjchem-2534	57	20	in	in	ADP
eurjchem-2534	57	21	the	the	DET
eurjchem-2534	57	22	treatment	treatment	NOUN
eurjchem-2534	57	23	of	of	ADP
eurjchem-2534	57	24	ra	ra	PROPN
eurjchem-2534	57	25	is	be	AUX
eurjchem-2534	57	26	not	not	PART
eurjchem-2534	57	27	yet	yet	ADV
eurjchem-2534	57	28	fully	fully	ADV
eurjchem-2534	57	29	understood	understand	VERB
eurjchem-2534	57	30	.	.	PUNCT
eurjchem-2534	58	1	research	research	NOUN
eurjchem-2534	58	2	indicates	indicate	VERB
eurjchem-2534	58	3	that	that	SCONJ
eurjchem-2534	58	4	celastrol	celastrol	NOUN
eurjchem-2534	58	5	can	can	AUX
eurjchem-2534	58	6	induce	induce	VERB
eurjchem-2534	58	7	endoplasmic	endoplasmic	ADJ
eurjchem-2534	58	8	reticulum	reticulum	NOUN
eurjchem-2534	58	9	(	(	PUNCT
eurjchem-2534	58	10	er	er	INTJ
eurjchem-2534	58	11	)	)	PUNCT
eurjchem-2534	58	12	stress	stress	NOUN
eurjchem-2534	58	13	through	through	ADP
eurjchem-2534	58	14	the	the	DET
eurjchem-2534	58	15	mobilization	mobilization	NOUN
eurjchem-2534	58	16	of	of	ADP
eurjchem-2534	58	17	intracellular	intracellular	ADJ
eurjchem-2534	58	18	calcium	calcium	NOUN
eurjchem-2534	58	19	(	(	PUNCT
eurjchem-2534	58	20	ca2	ca2	PROPN
eurjchem-2534	58	21	+	+	PROPN
eurjchem-2534	58	22	)	)	PUNCT
eurjchem-2534	58	23	,	,	PUNCT
eurjchem-2534	58	24	suggesting	suggest	VERB
eurjchem-2534	58	25	a	a	DET
eurjchem-2534	58	26	potential	potential	ADJ
eurjchem-2534	58	27	pathway	pathway	NOUN
eurjchem-2534	58	28	for	for	ADP
eurjchem-2534	58	29	its	its	PRON
eurjchem-2534	58	30	therapeutic	therapeutic	ADJ
eurjchem-2534	58	31	effects	effect	NOUN
eurjchem-2534	58	32	.	.	PUNCT
eurjchem-2534	59	1	however	however	ADV
eurjchem-2534	59	2	,	,	PUNCT
eurjchem-2534	59	3	more	more	ADJ
eurjchem-2534	59	4	studies	study	NOUN
eurjchem-2534	59	5	are	be	AUX
eurjchem-2534	59	6	needed	need	VERB
eurjchem-2534	59	7	to	to	PART
eurjchem-2534	59	8	elucidate	elucidate	VERB
eurjchem-2534	59	9	the	the	DET
eurjchem-2534	59	10	exact	exact	ADJ
eurjchem-2534	59	11	mechanisms	mechanism	NOUN
eurjchem-2534	59	12	by	by	ADP
eurjchem-2534	59	13	which	which	PRON
eurjchem-2534	59	14	celastrol	celastrol	NOUN
eurjchem-2534	59	15	influences	influence	VERB
eurjchem-2534	59	16	ca2	ca2	PROPN
eurjchem-2534	59	17	+	+	PROPN
eurjchem-2534	59	18	dynamics	dynamic	NOUN
eurjchem-2534	59	19	in	in	ADP
eurjchem-2534	59	20	ra	ra	PROPN
eurjchem-2534	60	1	[	[	X
eurjchem-2534	60	2	22	22	NUM
eurjchem-2534	60	3	]	]	PUNCT
eurjchem-2534	60	4	.	.	PUNCT
eurjchem-2534	61	1	celastrol	celastrol	PROPN
eurjchem-2534	61	2	was	be	AUX
eurjchem-2534	61	3	used	use	VERB
eurjchem-2534	61	4	as	as	ADP
eurjchem-2534	61	5	a	a	DET
eurjchem-2534	61	6	molecular	molecular	ADJ
eurjchem-2534	61	7	tool	tool	NOUN
eurjchem-2534	61	8	to	to	PART
eurjchem-2534	61	9	examine	examine	VERB
eurjchem-2534	61	10	the	the	DET
eurjchem-2534	61	11	profile	profile	NOUN
eurjchem-2534	61	12	of	of	ADP
eurjchem-2534	61	13	inflammatory	inflammatory	ADJ
eurjchem-2534	61	14	gene	gene	NOUN
eurjchem-2534	61	15	expression	expression	NOUN
eurjchem-2534	61	16	regulated	regulate	VERB
eurjchem-2534	61	17	by	by	ADP
eurjchem-2534	61	18	ca2	ca2	PROPN
eurjchem-2534	61	19	+	+	PROPN
eurjchem-2534	61	20	.	.	PUNCT
eurjchem-2534	62	1	in	in	ADP
eurjchem-2534	62	2	a	a	DET
eurjchem-2534	62	3	previous	previous	ADJ
eurjchem-2534	62	4	study	study	NOUN
eurjchem-2534	62	5	,	,	PUNCT
eurjchem-2534	62	6	wong	wong	PROPN
eurjchem-2534	62	7	et	et	PROPN
eurjchem-2534	62	8	al	al	PROPN
eurjchem-2534	62	9	.	.	PROPN
eurjchem-2534	62	10	found	find	VERB
eurjchem-2534	62	11	that	that	SCONJ
eurjchem-2534	62	12	treatment	treatment	NOUN
eurjchem-2534	62	13	with	with	ADP
eurjchem-2534	62	14	celastrol	celastrol	NOUN
eurjchem-2534	62	15	led	lead	VERB
eurjchem-2534	62	16	to	to	ADP
eurjchem-2534	62	17	cytosolic	cytosolic	NOUN
eurjchem-2534	62	18	ca2	ca2	PROPN
eurjchem-2534	62	19	+	+	PROPN
eurjchem-2534	62	20	mobilization	mobilization	NOUN
eurjchem-2534	62	21	in	in	ADP
eurjchem-2534	62	22	rheumatoid	rheumatoid	NOUN
eurjchem-2534	62	23	arthritis	arthritis	NOUN
eurjchem-2534	62	24	synovial	synovial	ADJ
eurjchem-2534	62	25	fibroblasts	fibroblast	NOUN
eurjchem-2534	62	26	(	(	PUNCT
eurjchem-2534	62	27	rasf	rasf	NOUN
eurjchem-2534	62	28	)	)	PUNCT
eurjchem-2534	62	29	derived	derive	VERB
eurjchem-2534	62	30	from	from	ADP
eurjchem-2534	62	31	patients	patient	NOUN
eurjchem-2534	62	32	[	[	X
eurjchem-2534	62	33	23	23	NUM
eurjchem-2534	62	34	]	]	PUNCT
eurjchem-2534	62	35	.	.	PUNCT
eurjchem-2534	63	1	in	in	ADP
eurjchem-2534	63	2	their	their	PRON
eurjchem-2534	63	3	study	study	NOUN
eurjchem-2534	63	4	[	[	X
eurjchem-2534	63	5	24	24	NUM
eurjchem-2534	63	6	]	]	PUNCT
eurjchem-2534	63	7	,	,	PUNCT
eurjchem-2534	63	8	wong	wong	PROPN
eurjchem-2534	63	9	et	et	PROPN
eurjchem-2534	63	10	al	al	PROPN
eurjchem-2534	63	11	.	.	PROPN
eurjchem-2534	63	12	investigated	investigate	VERB
eurjchem-2534	63	13	the	the	DET
eurjchem-2534	63	14	regulatory	regulatory	ADJ
eurjchem-2534	63	15	role	role	NOUN
eurjchem-2534	63	16	of	of	ADP
eurjchem-2534	63	17	celastrol	celastrol	NOUN
eurjchem-2534	63	18	-	-	PUNCT
eurjchem-2534	63	19	induced	induce	VERB
eurjchem-2534	63	20	ca2	ca2	PROPN
eurjchem-2534	63	21	+	+	NOUN
eurjchem-2534	63	22	signaling	signal	VERB
eurjchem-2534	63	23	in	in	ADP
eurjchem-2534	63	24	synovial	synovial	ADJ
eurjchem-2534	63	25	fibroblasts	fibroblast	NOUN
eurjchem-2534	63	26	of	of	ADP
eurjchem-2534	63	27	rheumatoid	rheumatoid	VERB
eurjchem-2534	63	28	arthritis	arthritis	NOUN
eurjchem-2534	63	29	patients	patient	NOUN
eurjchem-2534	63	30	and	and	CCONJ
eurjchem-2534	63	31	adjuvant	adjuvant	NOUN
eurjchem-2534	63	32	-	-	PUNCT
eurjchem-2534	63	33	induced	induce	VERB
eurjchem-2534	63	34	arthritis	arthritis	NOUN
eurjchem-2534	63	35	(	(	PUNCT
eurjchem-2534	63	36	aia	aia	PROPN
eurjchem-2534	63	37	)	)	PUNCT
eurjchem-2534	63	38	in	in	ADP
eurjchem-2534	63	39	rats	rat	NOUN
eurjchem-2534	63	40	.	.	PUNCT
eurjchem-2534	64	1	they	they	PRON
eurjchem-2534	64	2	employed	employ	VERB
eurjchem-2534	64	3	computational	computational	ADJ
eurjchem-2534	64	4	docking	docking	NOUN
eurjchem-2534	64	5	,	,	PUNCT
eurjchem-2534	64	6	ca2	ca2	PROPN
eurjchem-2534	64	7	+	+	PROPN
eurjchem-2534	64	8	dynamics	dynamic	NOUN
eurjchem-2534	64	9	,	,	PUNCT
eurjchem-2534	64	10	and	and	CCONJ
eurjchem-2534	64	11	functional	functional	ADJ
eurjchem-2534	64	12	assays	assay	NOUN
eurjchem-2534	64	13	to	to	PART
eurjchem-2534	64	14	examine	examine	VERB
eurjchem-2534	64	15	the	the	DET
eurjchem-2534	64	16	activity	activity	NOUN
eurjchem-2534	64	17	of	of	ADP
eurjchem-2534	64	18	the	the	DET
eurjchem-2534	64	19	sarcoplasmic	sarcoplasmic	ADJ
eurjchem-2534	64	20	/	/	SYM
eurjchem-2534	64	21	endoplasmic	endoplasmic	ADJ
eurjchem-2534	64	22	reticulum	reticulum	NOUN
eurjchem-2534	64	23	ca2	ca2	PROPN
eurjchem-2534	64	24	+	+	PROPN
eurjchem-2534	64	25	atpase	atpase	PROPN
eurjchem-2534	64	26	pump	pump	NOUN
eurjchem-2534	64	27	(	(	PUNCT
eurjchem-2534	64	28	serca	serca	PROPN
eurjchem-2534	64	29	)	)	PUNCT
eurjchem-2534	64	30	.	.	PUNCT
eurjchem-2534	65	1	the	the	DET
eurjchem-2534	65	2	sarco	sarco	PROPN
eurjchem-2534	65	3	-	-	PUNCT
eurjchem-2534	65	4	endoplasmic	endoplasmic	ADJ
eurjchem-2534	65	5	reticulum	reticulum	NOUN
eurjchem-2534	65	6	(	(	PUNCT
eurjchem-2534	65	7	sr	sr	PROPN
eurjchem-2534	65	8	)	)	PUNCT
eurjchem-2534	65	9	ca2	ca2	PROPN
eurjchem-2534	65	10	+	+	PROPN
eurjchem-2534	65	11	transport	transport	PROPN
eurjchem-2534	65	12	atpase	atpase	PROPN
eurjchem-2534	65	13	(	(	PUNCT
eurjchem-2534	65	14	serca	serca	PROPN
eurjchem-2534	65	15	)	)	PUNCT
eurjchem-2534	65	16	is	be	AUX
eurjchem-2534	65	17	the	the	DET
eurjchem-2534	65	18	sole	sole	ADJ
eurjchem-2534	65	19	pump	pump	NOUN
eurjchem-2534	65	20	responsible	responsible	ADJ
eurjchem-2534	65	21	for	for	ADP
eurjchem-2534	65	22	transporting	transport	VERB
eurjchem-2534	65	23	calcium	calcium	NOUN
eurjchem-2534	65	24	ions	ion	NOUN
eurjchem-2534	65	25	from	from	ADP
eurjchem-2534	65	26	the	the	DET
eurjchem-2534	65	27	cytoplasm	cytoplasm	NOUN
eurjchem-2534	65	28	into	into	ADP
eurjchem-2534	65	29	the	the	DET
eurjchem-2534	65	30	sr	sr	PROPN
eurjchem-2534	65	31	.	.	PUNCT
eurjchem-2534	66	1	the	the	DET
eurjchem-2534	66	2	study	study	NOUN
eurjchem-2534	66	3	reported	report	VERB
eurjchem-2534	66	4	that	that	SCONJ
eurjchem-2534	66	5	celastrol	celastrol	NOUN
eurjchem-2534	66	6	inhibited	inhibit	VERB
eurjchem-2534	66	7	the	the	DET
eurjchem-2534	66	8	sarcoplasmic	sarcoplasmic	NOUN
eurjchem-2534	66	9	/	/	SYM
eurjchem-2534	66	10	endoplasmic	endoplasmic	ADJ
eurjchem-2534	66	11	reticulum	reticulum	NOUN
eurjchem-2534	66	12	ca2	ca2	PROPN
eurjchem-2534	66	13	+	+	PROPN
eurjchem-2534	66	14	atpase	atpase	PROPN
eurjchem-2534	66	15	(	(	PUNCT
eurjchem-2534	66	16	serca	serca	PROPN
eurjchem-2534	66	17	)	)	PUNCT
eurjchem-2534	66	18	,	,	PUNCT
eurjchem-2534	66	19	triggering	trigger	VERB
eurjchem-2534	66	20	autophagydependent	autophagydependent	NOUN
eurjchem-2534	66	21	cytotoxicity	cytotoxicity	NOUN
eurjchem-2534	66	22	in	in	ADP
eurjchem-2534	66	23	rheumatoid	rheumatoid	NOUN
eurjchem-2534	66	24	arthritis	arthritis	NOUN
eurjchem-2534	66	25	synovial	synovial	ADJ
eurjchem-2534	66	26	fibroblasts	fibroblast	NOUN
eurjchem-2534	66	27	via	via	ADP
eurjchem-2534	66	28	the	the	DET
eurjchem-2534	66	29	ca2+/calmodulin	ca2+/calmodulin	NOUN
eurjchem-2534	66	30	-	-	PUNCT
eurjchem-2534	66	31	dependent	dependent	ADJ
eurjchem-2534	66	32	kinase	kinase	PROPN
eurjchem-2534	66	33	kinase	kinase	PROPN
eurjchem-2534	66	34	-	-	PUNCT
eurjchem-2534	66	35	βamp	βamp	PROPN
eurjchem-2534	66	36	-	-	PUNCT
eurjchem-2534	66	37	activated	activate	VERB
eurjchem-2534	66	38	protein	protein	NOUN
eurjchem-2534	66	39	kinase	kinase	NOUN
eurjchem-2534	66	40	-	-	PUNCT
eurjchem-2534	66	41	mtor	mtor	NOUN
eurjchem-2534	66	42	pathway	pathway	NOUN
eurjchem-2534	66	43	.	.	PUNCT
eurjchem-2534	67	1	this	this	DET
eurjchem-2534	67	2	action	action	NOUN
eurjchem-2534	67	3	also	also	ADV
eurjchem-2534	67	4	led	lead	VERB
eurjchem-2534	67	5	to	to	ADP
eurjchem-2534	67	6	suppression	suppression	NOUN
eurjchem-2534	67	7	of	of	ADP
eurjchem-2534	67	8	arthritis	arthritis	NOUN
eurjchem-2534	67	9	symptoms	symptom	NOUN
eurjchem-2534	67	10	in	in	ADP
eurjchem-2534	67	11	adjuvant	adjuvant	NOUN
eurjchem-2534	67	12	-	-	PUNCT
eurjchem-2534	67	13	induced	induce	VERB
eurjchem-2534	67	14	arthritis	arthritis	NOUN
eurjchem-2534	67	15	(	(	PUNCT
eurjchem-2534	67	16	aia	aia	NOUN
eurjchem-2534	67	17	)	)	PUNCT
eurjchem-2534	67	18	rats	rat	NOUN
eurjchem-2534	67	19	.	.	PUNCT
eurjchem-2534	68	1	2.1	2.1	NUM
eurjchem-2534	68	2	.	.	PUNCT
eurjchem-2534	68	3	medicinal	medicinal	ADJ
eurjchem-2534	68	4	chemistry	chemistry	NOUN
eurjchem-2534	68	5	of	of	ADP
eurjchem-2534	68	6	celastrol	celastrol	NOUN
eurjchem-2534	68	7	despite	despite	SCONJ
eurjchem-2534	68	8	the	the	DET
eurjchem-2534	68	9	beneficial	beneficial	ADJ
eurjchem-2534	68	10	therapeutic	therapeutic	ADJ
eurjchem-2534	68	11	properties	property	NOUN
eurjchem-2534	68	12	currently	currently	ADV
eurjchem-2534	68	13	understood	understand	VERB
eurjchem-2534	68	14	,	,	PUNCT
eurjchem-2534	68	15	it	it	PRON
eurjchem-2534	68	16	has	have	VERB
eurjchem-2534	68	17	some	some	DET
eurjchem-2534	68	18	undesirable	undesirable	ADJ
eurjchem-2534	68	19	pharmacological	pharmacological	ADJ
eurjchem-2534	68	20	properties	property	NOUN
eurjchem-2534	68	21	,	,	PUNCT
eurjchem-2534	68	22	such	such	ADJ
eurjchem-2534	68	23	as	as	ADP
eurjchem-2534	68	24	high	high	ADJ
eurjchem-2534	68	25	toxicity	toxicity	NOUN
eurjchem-2534	68	26	,	,	PUNCT
eurjchem-2534	68	27	poor	poor	ADJ
eurjchem-2534	68	28	water	water	NOUN
eurjchem-2534	68	29	solubility	solubility	NOUN
eurjchem-2534	68	30	,	,	PUNCT
eurjchem-2534	68	31	and	and	CCONJ
eurjchem-2534	68	32	stability	stability	NOUN
eurjchem-2534	68	33	,	,	PUNCT
eurjchem-2534	68	34	which	which	PRON
eurjchem-2534	68	35	hinder	hinder	VERB
eurjchem-2534	68	36	its	its	PRON
eurjchem-2534	68	37	future	future	ADJ
eurjchem-2534	68	38	clinical	clinical	ADJ
eurjchem-2534	68	39	application	application	NOUN
eurjchem-2534	68	40	[	[	X
eurjchem-2534	68	41	25	25	NUM
eurjchem-2534	68	42	]	]	PUNCT
eurjchem-2534	68	43	.	.	PUNCT
eurjchem-2534	69	1	196	196	NUM
eurjchem-2534	69	2	ren	ren	PROPN
eurjchem-2534	69	3	and	and	CCONJ
eurjchem-2534	69	4	coghi	coghi	PROPN
eurjchem-2534	69	5	/	/	SYM
eurjchem-2534	69	6	european	european	PROPN
eurjchem-2534	69	7	journal	journal	PROPN
eurjchem-2534	69	8	of	of	ADP
eurjchem-2534	69	9	chemistry	chemistry	NOUN
eurjchem-2534	69	10	15	15	NUM
eurjchem-2534	69	11	(	(	PUNCT
eurjchem-2534	69	12	2	2	NUM
eurjchem-2534	69	13	)	)	PUNCT
eurjchem-2534	69	14	(	(	PUNCT
eurjchem-2534	69	15	2024	2024	NUM
eurjchem-2534	69	16	)	)	PUNCT
eurjchem-2534	69	17	194	194	NUM
eurjchem-2534	69	18	-	-	SYM
eurjchem-2534	69	19	204	204	NUM
eurjchem-2534	69	20	2024	2024	NUM
eurjchem-2534	69	21	–	–	PUNCT
eurjchem-2534	69	22	european	european	ADJ
eurjchem-2534	69	23	journal	journal	NOUN
eurjchem-2534	69	24	of	of	ADP
eurjchem-2534	69	25	chemistry	chemistry	NOUN
eurjchem-2534	69	26	–	–	PUNCT
eurjchem-2534	69	27	cc	cc	NOUN
eurjchem-2534	69	28	by	by	ADP
eurjchem-2534	69	29	nc	nc	PROPN
eurjchem-2534	69	30	–	–	PUNCT
eurjchem-2534	69	31	doi	doi	PROPN
eurjchem-2534	69	32	:	:	PUNCT
eurjchem-2534	69	33	10.5155	10.5155	NUM
eurjchem-2534	69	34	/	/	SYM
eurjchem-2534	69	35	eurjchem.15.2.194	eurjchem.15.2.194	NUM
eurjchem-2534	69	36	-	-	PUNCT
eurjchem-2534	69	37	204.2534	204.2534	NUM
eurjchem-2534	69	38	figure	figure	NOUN
eurjchem-2534	69	39	2	2	NUM
eurjchem-2534	69	40	.	.	NOUN
eurjchem-2534	69	41	number	number	NOUN
eurjchem-2534	69	42	of	of	ADP
eurjchem-2534	69	43	articles	article	NOUN
eurjchem-2534	69	44	published	publish	VERB
eurjchem-2534	69	45	between	between	ADP
eurjchem-2534	69	46	2005	2005	NUM
eurjchem-2534	69	47	and	and	CCONJ
eurjchem-2534	69	48	2024	2024	NUM
eurjchem-2534	69	49	containing	contain	VERB
eurjchem-2534	69	50	the	the	DET
eurjchem-2534	69	51	keyword	keyword	NOUN
eurjchem-2534	69	52	“	"	PUNCT
eurjchem-2534	69	53	celastrol	celastrol	NOUN
eurjchem-2534	69	54	”	"	PUNCT
eurjchem-2534	69	55	according	accord	VERB
eurjchem-2534	69	56	to	to	ADP
eurjchem-2534	69	57	the	the	DET
eurjchem-2534	69	58	science	science	NOUN
eurjchem-2534	69	59	finder	finder	PROPN
eurjchem-2534	69	60	database	database	PROPN
eurjchem-2534	69	61	.	.	PUNCT
eurjchem-2534	70	1	this	this	DET
eurjchem-2534	70	2	bar	bar	NOUN
eurjchem-2534	70	3	graph	graph	NOUN
eurjchem-2534	70	4	shows	show	VERB
eurjchem-2534	70	5	a	a	DET
eurjchem-2534	70	6	noticeable	noticeable	ADJ
eurjchem-2534	70	7	increase	increase	NOUN
eurjchem-2534	70	8	in	in	ADP
eurjchem-2534	70	9	publications	publication	NOUN
eurjchem-2534	70	10	over	over	ADP
eurjchem-2534	70	11	the	the	DET
eurjchem-2534	70	12	years	year	NOUN
eurjchem-2534	70	13	,	,	PUNCT
eurjchem-2534	70	14	indicating	indicate	VERB
eurjchem-2534	70	15	a	a	DET
eurjchem-2534	70	16	growing	grow	VERB
eurjchem-2534	70	17	interest	interest	NOUN
eurjchem-2534	70	18	in	in	ADP
eurjchem-2534	70	19	celastrol	celastrol	NOUN
eurjchem-2534	70	20	-	-	PUNCT
eurjchem-2534	70	21	related	relate	VERB
eurjchem-2534	70	22	research	research	NOUN
eurjchem-2534	70	23	.	.	PUNCT
eurjchem-2534	71	1	the	the	DET
eurjchem-2534	71	2	growing	grow	VERB
eurjchem-2534	71	3	trend	trend	NOUN
eurjchem-2534	71	4	reflects	reflect	VERB
eurjchem-2534	71	5	the	the	DET
eurjchem-2534	71	6	expanding	expand	VERB
eurjchem-2534	71	7	exploration	exploration	NOUN
eurjchem-2534	71	8	of	of	ADP
eurjchem-2534	71	9	celastrol	celastrol	NOUN
eurjchem-2534	71	10	’s	’s	PART
eurjchem-2534	71	11	pharmacological	pharmacological	ADJ
eurjchem-2534	71	12	properties	property	NOUN
eurjchem-2534	71	13	and	and	CCONJ
eurjchem-2534	71	14	its	its	PRON
eurjchem-2534	71	15	potential	potential	ADJ
eurjchem-2534	71	16	applications	application	NOUN
eurjchem-2534	71	17	in	in	ADP
eurjchem-2534	71	18	various	various	ADJ
eurjchem-2534	71	19	therapeutic	therapeutic	ADJ
eurjchem-2534	71	20	areas	area	NOUN
eurjchem-2534	71	21	.	.	PUNCT
eurjchem-2534	72	1	o	o	X
eurjchem-2534	72	2	ho	ho	PROPN
eurjchem-2534	72	3	h	h	PROPN
eurjchem-2534	72	4	celastrol	celastrol	NOUN
eurjchem-2534	72	5	(	(	PUNCT
eurjchem-2534	72	6	1	1	X
eurjchem-2534	72	7	)	)	PUNCT
eurjchem-2534	72	8	a	a	DET
eurjchem-2534	72	9	b	b	NOUN
eurjchem-2534	72	10	c	c	NOUN
eurjchem-2534	72	11	d	d	X
eurjchem-2534	72	12	e	e	NOUN
eurjchem-2534	73	1	oh	oh	INTJ
eurjchem-2534	73	2	o	o	NOUN
eurjchem-2534	73	3	a	a	DET
eurjchem-2534	73	4	/	/	SYM
eurjchem-2534	73	5	b	b	NOUN
eurjchem-2534	73	6	ring	ring	NOUN
eurjchem-2534	73	7	is	be	AUX
eurjchem-2534	73	8	connected	connect	VERB
eurjchem-2534	73	9	to	to	ADP
eurjchem-2534	73	10	activity	activity	NOUN
eurjchem-2534	73	11	(	(	PUNCT
eurjchem-2534	73	12	quinone	quinone	NOUN
eurjchem-2534	73	13	methide	methide	NOUN
eurjchem-2534	73	14	)	)	PUNCT
eurjchem-2534	73	15	,	,	PUNCT
eurjchem-2534	73	16	c-2	c-2	NOUN
eurjchem-2534	73	17	and	and	CCONJ
eurjchem-2534	73	18	c-3	c-3	PROPN
eurjchem-2534	73	19	can	can	AUX
eurjchem-2534	73	20	be	be	AUX
eurjchem-2534	73	21	modified	modify	VERB
eurjchem-2534	73	22	to	to	PART
eurjchem-2534	73	23	improve	improve	VERB
eurjchem-2534	73	24	activity	activity	NOUN
eurjchem-2534	73	25	;	;	PUNCT
eurjchem-2534	73	26	c-6	c-6	NOUN
eurjchem-2534	73	27	mainly	mainly	ADV
eurjchem-2534	73	28	introduced	introduce	VERB
eurjchem-2534	73	29	sulfonic	sulfonic	ADJ
eurjchem-2534	73	30	and	and	CCONJ
eurjchem-2534	73	31	indole	indole	NOUN
eurjchem-2534	73	32	through	through	ADP
eurjchem-2534	73	33	nucleophilic	nucleophilic	ADJ
eurjchem-2534	73	34	reaction	reaction	NOUN
eurjchem-2534	73	35	can	can	AUX
eurjchem-2534	73	36	generate	generate	VERB
eurjchem-2534	73	37	derivative	derivative	NOUN
eurjchem-2534	73	38	with	with	ADP
eurjchem-2534	73	39	increased	increase	VERB
eurjchem-2534	73	40	activity	activity	NOUN
eurjchem-2534	73	41	c-20	c-20	NOUN
eurjchem-2534	73	42	carboxyl	carboxyl	NOUN
eurjchem-2534	73	43	group	group	NOUN
eurjchem-2534	73	44	is	be	AUX
eurjchem-2534	73	45	the	the	DET
eurjchem-2534	73	46	main	main	ADJ
eurjchem-2534	73	47	modifying	modify	VERB
eurjchem-2534	73	48	group	group	NOUN
eurjchem-2534	73	49	,	,	PUNCT
eurjchem-2534	73	50	and	and	CCONJ
eurjchem-2534	73	51	its	its	PRON
eurjchem-2534	73	52	physicochemical	physicochemical	ADJ
eurjchem-2534	73	53	properties	property	NOUN
eurjchem-2534	73	54	can	can	AUX
eurjchem-2534	73	55	be	be	AUX
eurjchem-2534	73	56	improved	improve	VERB
eurjchem-2534	73	57	mainly	mainly	ADV
eurjchem-2534	73	58	through	through	ADP
eurjchem-2534	73	59	esterfication	esterfication	NOUN
eurjchem-2534	73	60	reaction	reaction	NOUN
eurjchem-2534	73	61	and	and	CCONJ
eurjchem-2534	73	62	amide	amide	NOUN
eurjchem-2534	73	63	reaction	reaction	NOUN
eurjchem-2534	73	64	modification	modification	NOUN
eurjchem-2534	73	65	of	of	ADP
eurjchem-2534	73	66	c-3	c-3	PROPN
eurjchem-2534	73	67	hydroxyl	hydroxyl	PROPN
eurjchem-2534	73	68	group	group	NOUN
eurjchem-2534	73	69	are	be	AUX
eurjchem-2534	73	70	important	important	ADJ
eurjchem-2534	73	71	factor	factor	NOUN
eurjchem-2534	73	72	for	for	ADP
eurjchem-2534	73	73	antiproliferative	antiproliferative	NOUN
eurjchem-2534	73	74	and	and	CCONJ
eurjchem-2534	73	75	neuroprotective	neuroprotective	ADJ
eurjchem-2534	73	76	activity	activity	NOUN
eurjchem-2534	73	77	1	1	NUM
eurjchem-2534	73	78	4	4	NUM
eurjchem-2534	73	79	6	6	NUM
eurjchem-2534	73	80	8	8	NUM
eurjchem-2534	73	81	20	20	NUM
eurjchem-2534	73	82	2	2	NUM
eurjchem-2534	73	83	3	3	NUM
eurjchem-2534	73	84	29	29	NUM
eurjchem-2534	73	85	figure	figure	NOUN
eurjchem-2534	73	86	3	3	NUM
eurjchem-2534	73	87	.	.	PUNCT
eurjchem-2534	74	1	the	the	DET
eurjchem-2534	74	2	structure	structure	NOUN
eurjchem-2534	74	3	-	-	PUNCT
eurjchem-2534	74	4	activity	activity	NOUN
eurjchem-2534	74	5	relationship	relationship	NOUN
eurjchem-2534	74	6	of	of	ADP
eurjchem-2534	74	7	celastrol	celastrol	NOUN
eurjchem-2534	74	8	.	.	PUNCT
eurjchem-2534	75	1	based	base	VERB
eurjchem-2534	75	2	on	on	ADP
eurjchem-2534	75	3	the	the	DET
eurjchem-2534	75	4	analysis	analysis	NOUN
eurjchem-2534	75	5	of	of	ADP
eurjchem-2534	75	6	the	the	DET
eurjchem-2534	75	7	structure	structure	NOUN
eurjchem-2534	75	8	of	of	ADP
eurjchem-2534	75	9	celastrol	celastrol	NOUN
eurjchem-2534	75	10	,	,	PUNCT
eurjchem-2534	75	11	it	it	PRON
eurjchem-2534	75	12	was	be	AUX
eurjchem-2534	75	13	found	find	VERB
eurjchem-2534	75	14	that	that	SCONJ
eurjchem-2534	75	15	the	the	DET
eurjchem-2534	75	16	quinone	quinone	NOUN
eurjchem-2534	75	17	methyl	methyl	NOUN
eurjchem-2534	75	18	of	of	ADP
eurjchem-2534	75	19	the	the	DET
eurjchem-2534	75	20	a	a	PROPN
eurjchem-2534	75	21	/	/	SYM
eurjchem-2534	75	22	b	b	NOUN
eurjchem-2534	75	23	rings	ring	NOUN
eurjchem-2534	75	24	,	,	PUNCT
eurjchem-2534	75	25	the	the	DET
eurjchem-2534	75	26	hydroxyl	hydroxyl	NOUN
eurjchem-2534	75	27	at	at	ADP
eurjchem-2534	75	28	the	the	DET
eurjchem-2534	75	29	c-3	c-3	PROPN
eurjchem-2534	75	30	position	position	NOUN
eurjchem-2534	75	31	,	,	PUNCT
eurjchem-2534	75	32	and	and	CCONJ
eurjchem-2534	75	33	the	the	DET
eurjchem-2534	75	34	carboxyl	carboxyl	NOUN
eurjchem-2534	75	35	group	group	NOUN
eurjchem-2534	75	36	at	at	ADP
eurjchem-2534	75	37	the	the	DET
eurjchem-2534	75	38	29	29	NUM
eurjchem-2534	75	39	-	-	PUNCT
eurjchem-2534	75	40	position	position	NOUN
eurjchem-2534	75	41	were	be	AUX
eurjchem-2534	75	42	the	the	DET
eurjchem-2534	75	43	main	main	ADJ
eurjchem-2534	75	44	pharmacodynamic	pharmacodynamic	ADJ
eurjchem-2534	75	45	groups	group	NOUN
eurjchem-2534	75	46	.	.	PUNCT
eurjchem-2534	76	1	among	among	ADP
eurjchem-2534	76	2	them	they	PRON
eurjchem-2534	76	3	,	,	PUNCT
eurjchem-2534	76	4	the	the	DET
eurjchem-2534	76	5	c-29	c-29	VERB
eurjchem-2534	76	6	carboxylic	carboxylic	ADJ
eurjchem-2534	76	7	group	group	NOUN
eurjchem-2534	76	8	is	be	AUX
eurjchem-2534	76	9	the	the	DET
eurjchem-2534	76	10	prime	prime	ADJ
eurjchem-2534	76	11	modification	modification	NOUN
eurjchem-2534	76	12	site	site	NOUN
eurjchem-2534	76	13	of	of	ADP
eurjchem-2534	76	14	celastrol	celastrol	NOUN
eurjchem-2534	76	15	(	(	PUNCT
eurjchem-2534	76	16	green	green	ADJ
eurjchem-2534	76	17	site	site	NOUN
eurjchem-2534	76	18	)	)	PUNCT
eurjchem-2534	76	19	,	,	PUNCT
eurjchem-2534	76	20	which	which	PRON
eurjchem-2534	76	21	can	can	AUX
eurjchem-2534	76	22	play	play	VERB
eurjchem-2534	76	23	a	a	DET
eurjchem-2534	76	24	key	key	ADJ
eurjchem-2534	76	25	role	role	NOUN
eurjchem-2534	76	26	in	in	ADP
eurjchem-2534	76	27	its	its	PRON
eurjchem-2534	76	28	chaperone	chaperone	NOUN
eurjchem-2534	76	29	activity	activity	NOUN
eurjchem-2534	76	30	(	(	PUNCT
eurjchem-2534	76	31	i	i	NOUN
eurjchem-2534	76	32	)	)	PUNCT
eurjchem-2534	76	33	;	;	PUNCT
eurjchem-2534	76	34	modification	modification	NOUN
eurjchem-2534	76	35	of	of	ADP
eurjchem-2534	76	36	c-6	c-6	NOUN
eurjchem-2534	76	37	with	with	ADP
eurjchem-2534	76	38	c‒s	c‒s	PROPN
eurjchem-2534	76	39	or	or	CCONJ
eurjchem-2534	76	40	c‒c	c‒c	ADJ
eurjchem-2534	76	41	bonds	bond	NOUN
eurjchem-2534	76	42	could	could	AUX
eurjchem-2534	76	43	generate	generate	VERB
eurjchem-2534	76	44	derivatives	derivative	NOUN
eurjchem-2534	76	45	with	with	ADP
eurjchem-2534	76	46	increased	increase	VERB
eurjchem-2534	76	47	antiproliferactive	antiproliferactive	ADJ
eurjchem-2534	76	48	activities	activity	NOUN
eurjchem-2534	76	49	(	(	PUNCT
eurjchem-2534	76	50	red	red	ADJ
eurjchem-2534	76	51	site	site	NOUN
eurjchem-2534	76	52	)	)	PUNCT
eurjchem-2534	76	53	(	(	PUNCT
eurjchem-2534	76	54	ii	ii	NOUN
eurjchem-2534	76	55	)	)	PUNCT
eurjchem-2534	76	56	;	;	PUNCT
eurjchem-2534	76	57	the	the	DET
eurjchem-2534	76	58	c-3	c-3	PROPN
eurjchem-2534	76	59	hydroxyl	hydroxyl	PROPN
eurjchem-2534	76	60	group	group	NOUN
eurjchem-2534	76	61	plays	play	VERB
eurjchem-2534	76	62	a	a	DET
eurjchem-2534	76	63	key	key	ADJ
eurjchem-2534	76	64	role	role	NOUN
eurjchem-2534	76	65	in	in	ADP
eurjchem-2534	76	66	its	its	PRON
eurjchem-2534	76	67	antiproliferative	antiproliferative	ADJ
eurjchem-2534	76	68	activity	activity	NOUN
eurjchem-2534	76	69	and	and	CCONJ
eurjchem-2534	76	70	neuroprotective	neuroprotective	ADJ
eurjchem-2534	76	71	activity	activity	NOUN
eurjchem-2534	76	72	(	(	PUNCT
eurjchem-2534	76	73	blue	blue	ADJ
eurjchem-2534	76	74	site	site	NOUN
eurjchem-2534	76	75	)	)	PUNCT
eurjchem-2534	76	76	(	(	PUNCT
eurjchem-2534	76	77	iii	iii	NOUN
eurjchem-2534	76	78	)	)	PUNCT
eurjchem-2534	76	79	.	.	PUNCT
eurjchem-2534	77	1	reviews	review	NOUN
eurjchem-2534	77	2	related	relate	VERB
eurjchem-2534	77	3	to	to	ADP
eurjchem-2534	77	4	its	its	PRON
eurjchem-2534	77	5	structural	structural	ADJ
eurjchem-2534	77	6	modifications	modification	NOUN
eurjchem-2534	77	7	,	,	PUNCT
eurjchem-2534	77	8	structureactivity	structureactivity	NOUN
eurjchem-2534	77	9	relationships	relationship	NOUN
eurjchem-2534	77	10	(	(	PUNCT
eurjchem-2534	77	11	sar	sar	NOUN
eurjchem-2534	77	12	)	)	PUNCT
eurjchem-2534	77	13	,	,	PUNCT
eurjchem-2534	77	14	pharmacology	pharmacology	NOUN
eurjchem-2534	77	15	,	,	PUNCT
eurjchem-2534	77	16	and	and	CCONJ
eurjchem-2534	77	17	toxicology	toxicology	NOUN
eurjchem-2534	77	18	have	have	AUX
eurjchem-2534	77	19	emerged	emerge	VERB
eurjchem-2534	77	20	recently	recently	ADV
eurjchem-2534	77	21	(	(	PUNCT
eurjchem-2534	77	22	figure	figure	NOUN
eurjchem-2534	77	23	2	2	NUM
eurjchem-2534	77	24	)	)	PUNCT
eurjchem-2534	77	25	.	.	PUNCT
eurjchem-2534	78	1	in	in	ADP
eurjchem-2534	78	2	recent	recent	ADJ
eurjchem-2534	78	3	years	year	NOUN
eurjchem-2534	78	4	,	,	PUNCT
eurjchem-2534	78	5	great	great	ADJ
eurjchem-2534	78	6	effort	effort	NOUN
eurjchem-2534	78	7	has	have	AUX
eurjchem-2534	78	8	been	be	AUX
eurjchem-2534	78	9	devoted	devote	VERB
eurjchem-2534	78	10	to	to	ADP
eurjchem-2534	78	11	the	the	DET
eurjchem-2534	78	12	study	study	NOUN
eurjchem-2534	78	13	of	of	ADP
eurjchem-2534	78	14	celastrol	celastrol	NOUN
eurjchem-2534	78	15	structure	structure	NOUN
eurjchem-2534	78	16	-	-	PUNCT
eurjchem-2534	78	17	activity	activity	NOUN
eurjchem-2534	78	18	relationships	relationship	NOUN
eurjchem-2534	78	19	(	(	PUNCT
eurjchem-2534	78	20	sars	sars	PROPN
eurjchem-2534	78	21	)	)	PUNCT
eurjchem-2534	78	22	(	(	PUNCT
eurjchem-2534	78	23	figure	figure	NOUN
eurjchem-2534	78	24	3	3	NUM
eurjchem-2534	78	25	)	)	PUNCT
eurjchem-2534	78	26	.	.	PUNCT
eurjchem-2534	79	1	many	many	ADJ
eurjchem-2534	79	2	studies	study	NOUN
eurjchem-2534	79	3	[	[	X
eurjchem-2534	79	4	26,27	26,27	NUM
eurjchem-2534	79	5	]	]	X
eurjchem-2534	79	6	on	on	ADP
eurjchem-2534	79	7	the	the	DET
eurjchem-2534	79	8	chemical	chemical	NOUN
eurjchem-2534	79	9	modification	modification	NOUN
eurjchem-2534	79	10	of	of	ADP
eurjchem-2534	79	11	celastrol	celastrol	NOUN
eurjchem-2534	79	12	have	have	AUX
eurjchem-2534	79	13	been	be	AUX
eurjchem-2534	79	14	carried	carry	VERB
eurjchem-2534	79	15	out	out	ADP
eurjchem-2534	79	16	at	at	ADP
eurjchem-2534	79	17	home	home	NOUN
eurjchem-2534	79	18	and	and	CCONJ
eurjchem-2534	79	19	abroad	abroad	ADV
eurjchem-2534	79	20	in	in	ADP
eurjchem-2534	79	21	the	the	DET
eurjchem-2534	79	22	last	last	ADJ
eurjchem-2534	79	23	decade	decade	NOUN
eurjchem-2534	79	24	,	,	PUNCT
eurjchem-2534	79	25	and	and	CCONJ
eurjchem-2534	79	26	the	the	DET
eurjchem-2534	79	27	preliminary	preliminary	ADJ
eurjchem-2534	79	28	sars	sar	NOUN
eurjchem-2534	79	29	are	be	AUX
eurjchem-2534	79	30	as	as	SCONJ
eurjchem-2534	79	31	follows	follow	VERB
eurjchem-2534	79	32	(	(	PUNCT
eurjchem-2534	79	33	figure	figure	NOUN
eurjchem-2534	79	34	3	3	NUM
eurjchem-2534	79	35	)	)	PUNCT
eurjchem-2534	79	36	.	.	PUNCT
eurjchem-2534	80	1	(	(	PUNCT
eurjchem-2534	80	2	i	i	NOUN
eurjchem-2534	80	3	)	)	PUNCT
eurjchem-2534	80	4	the	the	DET
eurjchem-2534	80	5	c-29	c-29	PUNCT
eurjchem-2534	80	6	carboxylic	carboxylic	ADJ
eurjchem-2534	80	7	group	group	NOUN
eurjchem-2534	80	8	stands	stand	VERB
eurjchem-2534	80	9	out	out	ADP
eurjchem-2534	80	10	as	as	ADP
eurjchem-2534	80	11	the	the	DET
eurjchem-2534	80	12	primary	primary	ADJ
eurjchem-2534	80	13	site	site	NOUN
eurjchem-2534	80	14	for	for	ADP
eurjchem-2534	80	15	modification	modification	NOUN
eurjchem-2534	80	16	in	in	ADP
eurjchem-2534	80	17	celastrol	celastrol	NOUN
eurjchem-2534	80	18	,	,	PUNCT
eurjchem-2534	80	19	potentially	potentially	ADV
eurjchem-2534	80	20	influencing	influence	VERB
eurjchem-2534	80	21	its	its	PRON
eurjchem-2534	80	22	chaperone	chaperone	NOUN
eurjchem-2534	80	23	activity	activity	NOUN
eurjchem-2534	80	24	significantly	significantly	ADV
eurjchem-2534	80	25	.	.	PUNCT
eurjchem-2534	81	1	typically	typically	ADV
eurjchem-2534	81	2	,	,	PUNCT
eurjchem-2534	81	3	structural	structural	ADJ
eurjchem-2534	81	4	modifications	modification	NOUN
eurjchem-2534	81	5	aim	aim	VERB
eurjchem-2534	81	6	to	to	PART
eurjchem-2534	81	7	introduce	introduce	VERB
eurjchem-2534	81	8	various	various	ADJ
eurjchem-2534	81	9	groups	group	NOUN
eurjchem-2534	81	10	through	through	ADP
eurjchem-2534	81	11	acylation	acylation	NOUN
eurjchem-2534	81	12	and	and	CCONJ
eurjchem-2534	81	13	esterification	esterification	NOUN
eurjchem-2534	81	14	,	,	PUNCT
eurjchem-2534	81	15	with	with	ADP
eurjchem-2534	81	16	the	the	DET
eurjchem-2534	81	17	goal	goal	NOUN
eurjchem-2534	81	18	of	of	ADP
eurjchem-2534	81	19	developing	develop	VERB
eurjchem-2534	81	20	potential	potential	ADJ
eurjchem-2534	81	21	drug	drug	NOUN
eurjchem-2534	81	22	candidates	candidate	NOUN
eurjchem-2534	81	23	exhibiting	exhibit	VERB
eurjchem-2534	81	24	enhanced	enhance	VERB
eurjchem-2534	81	25	pharmacological	pharmacological	ADJ
eurjchem-2534	81	26	profiles	profile	NOUN
eurjchem-2534	81	27	and	and	CCONJ
eurjchem-2534	81	28	minimal	minimal	ADJ
eurjchem-2534	81	29	toxicity	toxicity	NOUN
eurjchem-2534	81	30	[	[	X
eurjchem-2534	81	31	28	28	NUM
eurjchem-2534	81	32	]	]	PUNCT
eurjchem-2534	81	33	.	.	PUNCT
eurjchem-2534	82	1	the	the	DET
eurjchem-2534	82	2	addition	addition	NOUN
eurjchem-2534	82	3	of	of	ADP
eurjchem-2534	82	4	halogen	halogen	NOUN
eurjchem-2534	82	5	elements	element	NOUN
eurjchem-2534	82	6	,	,	PUNCT
eurjchem-2534	82	7	a	a	DET
eurjchem-2534	82	8	benzene	benzene	NOUN
eurjchem-2534	82	9	ring	ring	NOUN
eurjchem-2534	82	10	,	,	PUNCT
eurjchem-2534	82	11	and	and	CCONJ
eurjchem-2534	82	12	a	a	DET
eurjchem-2534	82	13	hydroxyl	hydroxyl	NOUN
eurjchem-2534	82	14	group	group	NOUN
eurjchem-2534	82	15	significantly	significantly	ADV
eurjchem-2534	82	16	improved	improve	VERB
eurjchem-2534	82	17	the	the	DET
eurjchem-2534	82	18	anticancer	anticancer	NOUN
eurjchem-2534	82	19	effectiveness	effectiveness	NOUN
eurjchem-2534	82	20	of	of	ADP
eurjchem-2534	82	21	the	the	DET
eurjchem-2534	82	22	compounds	compound	NOUN
eurjchem-2534	82	23	.	.	PUNCT
eurjchem-2534	83	1	however	however	ADV
eurjchem-2534	83	2	,	,	PUNCT
eurjchem-2534	83	3	the	the	DET
eurjchem-2534	83	4	efficacy	efficacy	NOUN
eurjchem-2534	83	5	of	of	ADP
eurjchem-2534	83	6	six	six	NUM
eurjchem-2534	83	7	-	-	PUNCT
eurjchem-2534	83	8	ring	ring	NOUN
eurjchem-2534	83	9	variants	variant	NOUN
eurjchem-2534	83	10	decreased	decrease	VERB
eurjchem-2534	83	11	markedly	markedly	ADV
eurjchem-2534	83	12	[	[	X
eurjchem-2534	83	13	25	25	NUM
eurjchem-2534	83	14	]	]	PUNCT
eurjchem-2534	83	15	.	.	PUNCT
eurjchem-2534	84	1	in	in	ADP
eurjchem-2534	84	2	particular	particular	ADJ
eurjchem-2534	84	3	,	,	PUNCT
eurjchem-2534	84	4	alterations	alteration	NOUN
eurjchem-2534	84	5	to	to	ADP
eurjchem-2534	84	6	the	the	DET
eurjchem-2534	84	7	carboxylic	carboxylic	ADJ
eurjchem-2534	84	8	acid	acid	NOUN
eurjchem-2534	84	9	group	group	NOUN
eurjchem-2534	84	10	of	of	ADP
eurjchem-2534	84	11	celastrol	celastrol	NOUN
eurjchem-2534	84	12	did	do	AUX
eurjchem-2534	84	13	not	not	PART
eurjchem-2534	84	14	substantially	substantially	ADV
eurjchem-2534	84	15	affect	affect	VERB
eurjchem-2534	84	16	its	its	PRON
eurjchem-2534	84	17	ability	ability	NOUN
eurjchem-2534	84	18	to	to	PART
eurjchem-2534	84	19	disrupt	disrupt	VERB
eurjchem-2534	84	20	hsp90	hsp90	ADJ
eurjchem-2534	84	21	/	/	SYM
eurjchem-2534	84	22	cdc37	cdc37	NOUN
eurjchem-2534	84	23	inhibition	inhibition	NOUN
eurjchem-2534	84	24	.	.	PUNCT
eurjchem-2534	85	1	however	however	ADV
eurjchem-2534	85	2	,	,	PUNCT
eurjchem-2534	85	3	derivatives	derivative	NOUN
eurjchem-2534	85	4	featuring	feature	VERB
eurjchem-2534	85	5	aromatic	aromatic	ADJ
eurjchem-2534	85	6	phenyl	phenyl	NOUN
eurjchem-2534	85	7	substituents	substituent	NOUN
eurjchem-2534	85	8	exhibited	exhibit	VERB
eurjchem-2534	85	9	potentially	potentially	ADV
eurjchem-2534	85	10	reduced	reduce	VERB
eurjchem-2534	85	11	toxicity	toxicity	NOUN
eurjchem-2534	85	12	to	to	ADP
eurjchem-2534	85	13	normal	normal	ADJ
eurjchem-2534	85	14	cells	cell	NOUN
eurjchem-2534	85	15	compared	compare	VERB
eurjchem-2534	85	16	to	to	ADP
eurjchem-2534	85	17	those	those	PRON
eurjchem-2534	85	18	with	with	ADP
eurjchem-2534	85	19	nonaromatic	nonaromatic	ADJ
eurjchem-2534	85	20	alkyl	alkyl	ADJ
eurjchem-2534	85	21	groups	group	NOUN
eurjchem-2534	85	22	.	.	PUNCT
eurjchem-2534	86	1	furthermore	furthermore	ADV
eurjchem-2534	86	2	,	,	PUNCT
eurjchem-2534	86	3	the	the	DET
eurjchem-2534	86	4	conjugation	conjugation	NOUN
eurjchem-2534	86	5	of	of	ADP
eurjchem-2534	86	6	celastrol	celastrol	NOUN
eurjchem-2534	86	7	with	with	ADP
eurjchem-2534	86	8	other	other	ADJ
eurjchem-2534	86	9	mechanistically	mechanistically	ADV
eurjchem-2534	86	10	distinct	distinct	ADJ
eurjchem-2534	86	11	anticancer	anticancer	NOUN
eurjchem-2534	86	12	agents	agent	NOUN
eurjchem-2534	86	13	,	,	PUNCT
eurjchem-2534	86	14	such	such	ADJ
eurjchem-2534	86	15	as	as	ADP
eurjchem-2534	86	16	ferulic	ferulic	ADJ
eurjchem-2534	86	17	acid	acid	NOUN
eurjchem-2534	86	18	and	and	CCONJ
eurjchem-2534	86	19	its	its	PRON
eurjchem-2534	86	20	derivatives	derivative	NOUN
eurjchem-2534	86	21	,	,	PUNCT
eurjchem-2534	86	22	or	or	CCONJ
eurjchem-2534	86	23	biotins	biotin	NOUN
eurjchem-2534	86	24	through	through	ADP
eurjchem-2534	86	25	the	the	DET
eurjchem-2534	86	26	c-29	c-29	PUNCT
eurjchem-2534	86	27	carboxylic	carboxylic	ADJ
eurjchem-2534	86	28	group	group	NOUN
eurjchem-2534	86	29	,	,	PUNCT
eurjchem-2534	86	30	has	have	VERB
eurjchem-2534	86	31	the	the	DET
eurjchem-2534	86	32	potential	potential	NOUN
eurjchem-2534	86	33	to	to	PART
eurjchem-2534	86	34	produce	produce	VERB
eurjchem-2534	86	35	hybrids	hybrid	NOUN
eurjchem-2534	86	36	with	with	ADP
eurjchem-2534	86	37	synergistic	synergistic	ADJ
eurjchem-2534	86	38	effects	effect	NOUN
eurjchem-2534	86	39	or	or	CCONJ
eurjchem-2534	86	40	targeted	target	VERB
eurjchem-2534	86	41	delivery	delivery	NOUN
eurjchem-2534	86	42	capabilities	capability	NOUN
eurjchem-2534	86	43	(	(	PUNCT
eurjchem-2534	86	44	figure	figure	NOUN
eurjchem-2534	86	45	4	4	NUM
eurjchem-2534	86	46	)	)	PUNCT
eurjchem-2534	87	1	[	[	X
eurjchem-2534	87	2	29	29	NUM
eurjchem-2534	87	3	-	-	SYM
eurjchem-2534	87	4	31	31	NUM
eurjchem-2534	87	5	]	]	PUNCT
eurjchem-2534	87	6	.	.	PUNCT
eurjchem-2534	88	1	we	we	PRON
eurjchem-2534	88	2	previously	previously	ADV
eurjchem-2534	88	3	designed	design	VERB
eurjchem-2534	88	4	,	,	PUNCT
eurjchem-2534	88	5	synthesized	synthesize	VERB
eurjchem-2534	88	6	,	,	PUNCT
eurjchem-2534	88	7	and	and	CCONJ
eurjchem-2534	88	8	evaluated	evaluate	VERB
eurjchem-2534	88	9	the	the	DET
eurjchem-2534	88	10	eleven	eleven	NUM
eurjchem-2534	88	11	celastrol	celastrol	NOUN
eurjchem-2534	88	12	derivatives	derivative	NOUN
eurjchem-2534	88	13	for	for	ADP
eurjchem-2534	88	14	their	their	PRON
eurjchem-2534	88	15	in	in	X
eurjchem-2534	88	16	vitro	vitro	X
eurjchem-2534	88	17	cytotoxic	cytotoxic	ADJ
eurjchem-2534	88	18	activities	activity	NOUN
eurjchem-2534	88	19	against	against	ADP
eurjchem-2534	88	20	human	human	ADJ
eurjchem-2534	88	21	cancer	cancer	NOUN
eurjchem-2534	88	22	cell	cell	NOUN
eurjchem-2534	88	23	lines	line	NOUN
eurjchem-2534	88	24	and	and	CCONJ
eurjchem-2534	88	25	normal	normal	ADJ
eurjchem-2534	88	26	cells	cell	NOUN
eurjchem-2534	88	27	[	[	X
eurjchem-2534	88	28	32	32	NUM
eurjchem-2534	88	29	]	]	PUNCT
eurjchem-2534	88	30	.	.	PUNCT
eurjchem-2534	89	1	(	(	PUNCT
eurjchem-2534	89	2	ii	ii	NOUN
eurjchem-2534	89	3	)	)	PUNCT
eurjchem-2534	89	4	introducing	introduce	VERB
eurjchem-2534	89	5	c‒s	c‒s	PROPN
eurjchem-2534	89	6	or	or	CCONJ
eurjchem-2534	89	7	c‒c	c‒c	ADJ
eurjchem-2534	89	8	bonds	bond	NOUN
eurjchem-2534	89	9	at	at	ADP
eurjchem-2534	89	10	the	the	DET
eurjchem-2534	89	11	c-6	c-6	NOUN
eurjchem-2534	89	12	position	position	NOUN
eurjchem-2534	89	13	has	have	VERB
eurjchem-2534	89	14	the	the	DET
eurjchem-2534	89	15	potential	potential	NOUN
eurjchem-2534	89	16	to	to	PART
eurjchem-2534	89	17	produce	produce	VERB
eurjchem-2534	89	18	derivatives	derivative	NOUN
eurjchem-2534	89	19	with	with	ADP
eurjchem-2534	89	20	enhanced	enhanced	ADJ
eurjchem-2534	89	21	antiproliferative	antiproliferative	ADJ
eurjchem-2534	89	22	properties	property	NOUN
eurjchem-2534	89	23	.	.	PUNCT
eurjchem-2534	90	1	sulfonation	sulfonation	NOUN
eurjchem-2534	90	2	and	and	CCONJ
eurjchem-2534	90	3	sulfidation	sulfidation	NOUN
eurjchem-2534	90	4	at	at	ADP
eurjchem-2534	90	5	c-6	c-6	NOUN
eurjchem-2534	90	6	may	may	AUX
eurjchem-2534	90	7	increase	increase	VERB
eurjchem-2534	90	8	cytotoxicity	cytotoxicity	NOUN
eurjchem-2534	90	9	,	,	PUNCT
eurjchem-2534	90	10	whereas	whereas	SCONJ
eurjchem-2534	90	11	carbonation	carbonation	NOUN
eurjchem-2534	90	12	significantly	significantly	ADV
eurjchem-2534	90	13	decreases	decrease	VERB
eurjchem-2534	90	14	cytotoxic	cytotoxic	ADJ
eurjchem-2534	90	15	effects	effect	NOUN
eurjchem-2534	90	16	.	.	PUNCT
eurjchem-2534	91	1	furthermore	furthermore	ADV
eurjchem-2534	91	2	,	,	PUNCT
eurjchem-2534	91	3	subsequent	subsequent	ADJ
eurjchem-2534	91	4	acetylation	acetylation	NOUN
eurjchem-2534	91	5	at	at	ADP
eurjchem-2534	91	6	c-2	c-2	NOUN
eurjchem-2534	91	7	and	and	CCONJ
eurjchem-2534	91	8	c-3	c-3	NOUN
eurjchem-2534	91	9	is	be	AUX
eurjchem-2534	91	10	shown	show	VERB
eurjchem-2534	91	11	to	to	PART
eurjchem-2534	91	12	be	be	AUX
eurjchem-2534	91	13	more	more	ADV
eurjchem-2534	91	14	effective	effective	ADJ
eurjchem-2534	91	15	than	than	ADP
eurjchem-2534	91	16	propionylation	propionylation	NOUN
eurjchem-2534	91	17	in	in	ADP
eurjchem-2534	91	18	terms	term	NOUN
eurjchem-2534	91	19	of	of	ADP
eurjchem-2534	91	20	cytotoxicity	cytotoxicity	NOUN
eurjchem-2534	91	21	.	.	PUNCT
eurjchem-2534	92	1	while	while	SCONJ
eurjchem-2534	92	2	the	the	DET
eurjchem-2534	92	3	anticancer	anticancer	NOUN
eurjchem-2534	92	4	efficacy	efficacy	NOUN
eurjchem-2534	92	5	of	of	ADP
eurjchem-2534	92	6	6substituted	6substitute	VERB
eurjchem-2534	92	7	indole	indole	NOUN
eurjchem-2534	92	8	(	(	PUNCT
eurjchem-2534	92	9	figure	figure	NOUN
eurjchem-2534	92	10	5a	5a	NUM
eurjchem-2534	92	11	)	)	PUNCT
eurjchem-2534	92	12	exhibited	exhibit	VERB
eurjchem-2534	92	13	a	a	DET
eurjchem-2534	92	14	decrease	decrease	NOUN
eurjchem-2534	92	15	,	,	PUNCT
eurjchem-2534	92	16	the	the	DET
eurjchem-2534	92	17	addition	addition	NOUN
eurjchem-2534	92	18	of	of	ADP
eurjchem-2534	92	19	an	an	DET
eurjchem-2534	92	20	exocyclic	exocyclic	ADJ
eurjchem-2534	92	21	c	c	NOUN
eurjchem-2534	92	22	–	–	PUNCT
eurjchem-2534	92	23	c	c	NOUN
eurjchem-2534	92	24	bond	bond	NOUN
eurjchem-2534	92	25	at	at	ADP
eurjchem-2534	92	26	the	the	DET
eurjchem-2534	92	27	c-6	c-6	NOUN
eurjchem-2534	92	28	position	position	NOUN
eurjchem-2534	92	29	led	lead	VERB
eurjchem-2534	92	30	to	to	ADP
eurjchem-2534	92	31	the	the	DET
eurjchem-2534	92	32	deactivation	deactivation	NOUN
eurjchem-2534	92	33	of	of	ADP
eurjchem-2534	92	34	the	the	DET
eurjchem-2534	92	35	michael	michael	PROPN
eurjchem-2534	92	36	acceptor	acceptor	NOUN
eurjchem-2534	92	37	system	system	NOUN
eurjchem-2534	92	38	within	within	ADP
eurjchem-2534	92	39	the	the	DET
eurjchem-2534	92	40	ring	ring	NOUN
eurjchem-2534	92	41	a	a	DET
eurjchem-2534	92	42	(	(	PUNCT
eurjchem-2534	92	43	see	see	VERB
eurjchem-2534	92	44	figure	figure	NOUN
eurjchem-2534	92	45	3	3	NUM
eurjchem-2534	92	46	,	,	PUNCT
eurjchem-2534	92	47	red	red	ADJ
eurjchem-2534	92	48	square	square	NOUN
eurjchem-2534	92	49	)	)	PUNCT
eurjchem-2534	92	50	.	.	PUNCT
eurjchem-2534	93	1	this	this	DET
eurjchem-2534	93	2	observation	observation	NOUN
eurjchem-2534	93	3	suggests	suggest	VERB
eurjchem-2534	93	4	that	that	SCONJ
eurjchem-2534	93	5	the	the	DET
eurjchem-2534	93	6	presence	presence	NOUN
eurjchem-2534	93	7	of	of	ADP
eurjchem-2534	93	8	the	the	DET
eurjchem-2534	93	9	michael	michael	PROPN
eurjchem-2534	93	10	acceptor	acceptor	NOUN
eurjchem-2534	93	11	is	be	AUX
eurjchem-2534	93	12	not	not	PART
eurjchem-2534	93	13	always	always	ADV
eurjchem-2534	93	14	essential	essential	ADJ
eurjchem-2534	93	15	for	for	ADP
eurjchem-2534	93	16	potent	potent	ADJ
eurjchem-2534	93	17	cytotoxic	cytotoxic	ADJ
eurjchem-2534	93	18	activity	activity	NOUN
eurjchem-2534	93	19	[	[	X
eurjchem-2534	93	20	33	33	NUM
eurjchem-2534	93	21	]	]	PUNCT
eurjchem-2534	93	22	.	.	PUNCT
eurjchem-2534	94	1	(	(	PUNCT
eurjchem-2534	94	2	iii	iii	X
eurjchem-2534	94	3	)	)	PUNCT
eurjchem-2534	94	4	the	the	DET
eurjchem-2534	94	5	presence	presence	NOUN
eurjchem-2534	94	6	of	of	ADP
eurjchem-2534	94	7	the	the	DET
eurjchem-2534	94	8	c-3	c-3	PROPN
eurjchem-2534	94	9	hydroxyl	hydroxyl	PROPN
eurjchem-2534	94	10	group	group	NOUN
eurjchem-2534	94	11	is	be	AUX
eurjchem-2534	94	12	critical	critical	ADJ
eurjchem-2534	94	13	for	for	ADP
eurjchem-2534	94	14	both	both	CCONJ
eurjchem-2534	94	15	the	the	DET
eurjchem-2534	94	16	antiproliferative	antiproliferative	NOUN
eurjchem-2534	94	17	and	and	CCONJ
eurjchem-2534	94	18	neuroprotective	neuroprotective	ADJ
eurjchem-2534	94	19	properties	property	NOUN
eurjchem-2534	94	20	of	of	ADP
eurjchem-2534	94	21	the	the	DET
eurjchem-2534	94	22	compound	compound	NOUN
eurjchem-2534	94	23	.	.	PUNCT
eurjchem-2534	95	1	the	the	DET
eurjchem-2534	95	2	specific	specific	ADJ
eurjchem-2534	95	3	type	type	NOUN
eurjchem-2534	95	4	and	and	CCONJ
eurjchem-2534	95	5	dimensions	dimension	NOUN
eurjchem-2534	95	6	of	of	ADP
eurjchem-2534	95	7	the	the	DET
eurjchem-2534	95	8	carbamate	carbamate	ADJ
eurjchem-2534	95	9	substituents	substituent	NOUN
eurjchem-2534	95	10	attached	attach	VERB
eurjchem-2534	95	11	to	to	ADP
eurjchem-2534	95	12	this	this	DET
eurjchem-2534	95	13	hydroxyl	hydroxyl	NOUN
eurjchem-2534	95	14	group	group	NOUN
eurjchem-2534	95	15	significantly	significantly	ADV
eurjchem-2534	95	16	influenced	influence	VERB
eurjchem-2534	95	17	its	its	PRON
eurjchem-2534	95	18	cytotoxic	cytotoxic	ADJ
eurjchem-2534	95	19	efficacy	efficacy	NOUN
eurjchem-2534	95	20	in	in	ADP
eurjchem-2534	95	21	vitro	vitro	VERB
eurjchem-2534	95	22	.	.	PUNCT
eurjchem-2534	96	1	although	although	SCONJ
eurjchem-2534	96	2	modifying	modify	VERB
eurjchem-2534	96	3	the	the	DET
eurjchem-2534	96	4	c-3	c-3	NOUN
eurjchem-2534	96	5	hydroxyl	hydroxyl	PROPN
eurjchem-2534	96	6	group	group	NOUN
eurjchem-2534	96	7	with	with	ADP
eurjchem-2534	96	8	size	size	NOUN
eurjchem-2534	96	9	-	-	PUNCT
eurjchem-2534	96	10	constrained	constrain	VERB
eurjchem-2534	96	11	groups	group	NOUN
eurjchem-2534	96	12	had	have	VERB
eurjchem-2534	96	13	minimal	minimal	ADJ
eurjchem-2534	96	14	impact	impact	NOUN
eurjchem-2534	96	15	on	on	ADP
eurjchem-2534	96	16	its	its	PRON
eurjchem-2534	96	17	antiproliferative	antiproliferative	ADJ
eurjchem-2534	96	18	potential	potential	NOUN
eurjchem-2534	96	19	,	,	PUNCT
eurjchem-2534	96	20	incorporating	incorporate	VERB
eurjchem-2534	96	21	hydrophilic	hydrophilic	ADJ
eurjchem-2534	96	22	moieties	moiety	NOUN
eurjchem-2534	96	23	like	like	ADP
eurjchem-2534	96	24	piperazine	piperazine	NOUN
eurjchem-2534	96	25	proved	prove	VERB
eurjchem-2534	96	26	beneficial	beneficial	ADJ
eurjchem-2534	96	27	in	in	ADP
eurjchem-2534	96	28	improving	improve	VERB
eurjchem-2534	96	29	solubility	solubility	NOUN
eurjchem-2534	96	30	(	(	PUNCT
eurjchem-2534	96	31	figure	figure	NOUN
eurjchem-2534	96	32	5b	5b	NOUN
eurjchem-2534	97	1	[	[	X
eurjchem-2534	97	2	34,35	34,35	NOUN
eurjchem-2534	97	3	]	]	PUNCT
eurjchem-2534	97	4	.	.	PUNCT
eurjchem-2534	98	1	furthermore	furthermore	ADV
eurjchem-2534	98	2	,	,	PUNCT
eurjchem-2534	98	3	derivatives	derivative	NOUN
eurjchem-2534	98	4	obtained	obtain	VERB
eurjchem-2534	98	5	from	from	ADP
eurjchem-2534	98	6	the	the	DET
eurjchem-2534	98	7	coupling	coupling	NOUN
eurjchem-2534	98	8	of	of	ADP
eurjchem-2534	98	9	tripterine	tripterine	NOUN
eurjchem-2534	98	10	with	with	ADP
eurjchem-2534	98	11	anticancer	anticancer	NOUN
eurjchem-2534	98	12	drugs	drug	NOUN
eurjchem-2534	98	13	(	(	PUNCT
eurjchem-2534	98	14	lipoic	lipoic	ADJ
eurjchem-2534	98	15	acid	acid	NOUN
eurjchem-2534	98	16	or	or	CCONJ
eurjchem-2534	98	17	ligustrazine	ligustrazine	NOUN
eurjchem-2534	98	18	)	)	PUNCT
eurjchem-2534	98	19	can	can	AUX
eurjchem-2534	98	20	show	show	VERB
eurjchem-2534	98	21	cytoprotective	cytoprotective	ADJ
eurjchem-2534	98	22	effects	effect	NOUN
eurjchem-2534	98	23	against	against	ADP
eurjchem-2534	98	24	various	various	ADJ
eurjchem-2534	98	25	stress	stress	NOUN
eurjchem-2534	98	26	-	-	PUNCT
eurjchem-2534	98	27	induced	induce	VERB
eurjchem-2534	98	28	nerve	nerve	NOUN
eurjchem-2534	98	29	injuries	injury	NOUN
eurjchem-2534	98	30	[	[	X
eurjchem-2534	98	31	8	8	NUM
eurjchem-2534	98	32	]	]	PUNCT
eurjchem-2534	98	33	.	.	PUNCT
eurjchem-2534	99	1	15	15	NUM
eurjchem-2534	99	2	12	12	NUM
eurjchem-2534	99	3	32	32	NUM
eurjchem-2534	99	4	45	45	NUM
eurjchem-2534	99	5	54	54	NUM
eurjchem-2534	99	6	74	74	NUM
eurjchem-2534	99	7	80	80	NUM
eurjchem-2534	99	8	93	93	NUM
eurjchem-2534	99	9	113	113	NUM
eurjchem-2534	99	10	118	118	NUM
eurjchem-2534	99	11	126	126	NUM
eurjchem-2534	99	12	109	109	NUM
eurjchem-2534	99	13	124	124	NUM
eurjchem-2534	99	14	159	159	NUM
eurjchem-2534	99	15	141	141	NUM
eurjchem-2534	99	16	149	149	NUM
eurjchem-2534	99	17	178	178	NUM
eurjchem-2534	99	18	206	206	NUM
eurjchem-2534	99	19	192	192	NUM
eurjchem-2534	99	20	25	25	NUM
eurjchem-2534	99	21	0	0	NUM
eurjchem-2534	99	22	50	50	NUM
eurjchem-2534	99	23	100	100	NUM
eurjchem-2534	99	24	150	150	NUM
eurjchem-2534	99	25	200	200	NUM
eurjchem-2534	99	26	250	250	NUM
eurjchem-2534	99	27	2005	2005	NUM
eurjchem-2534	99	28	2010	2010	NUM
eurjchem-2534	99	29	2015	2015	NUM
eurjchem-2534	99	30	2020	2020	NUM
eurjchem-2534	99	31	2024	2024	NUM
eurjchem-2534	99	32	nu	nu	PROPN
eurjchem-2534	99	33	m	m	VERB
eurjchem-2534	99	34	be	be	VERB
eurjchem-2534	99	35	r	r	NOUN
eurjchem-2534	99	36	of	of	ADP
eurjchem-2534	99	37	a	a	DET
eurjchem-2534	99	38	rti	rti	PROPN
eurjchem-2534	99	39	cl	cl	NOUN
eurjchem-2534	99	40	es	es	NOUN
eurjchem-2534	99	41	year	year	NOUN
eurjchem-2534	99	42	ren	ren	PROPN
eurjchem-2534	99	43	and	and	CCONJ
eurjchem-2534	99	44	coghi	coghi	PROPN
eurjchem-2534	99	45	/	/	SYM
eurjchem-2534	99	46	european	european	PROPN
eurjchem-2534	99	47	journal	journal	PROPN
eurjchem-2534	99	48	of	of	ADP
eurjchem-2534	99	49	chemistry	chemistry	NOUN
eurjchem-2534	99	50	15	15	NUM
eurjchem-2534	99	51	(	(	PUNCT
eurjchem-2534	99	52	2	2	NUM
eurjchem-2534	99	53	)	)	PUNCT
eurjchem-2534	99	54	(	(	PUNCT
eurjchem-2534	99	55	2024	2024	NUM
eurjchem-2534	99	56	)	)	PUNCT
eurjchem-2534	99	57	194	194	NUM
eurjchem-2534	99	58	-	-	SYM
eurjchem-2534	99	59	204	204	NUM
eurjchem-2534	99	60	197	197	NUM
eurjchem-2534	99	61	2024	2024	NUM
eurjchem-2534	99	62	–	–	PUNCT
eurjchem-2534	99	63	european	european	ADJ
eurjchem-2534	99	64	journal	journal	NOUN
eurjchem-2534	99	65	of	of	ADP
eurjchem-2534	99	66	chemistry	chemistry	NOUN
eurjchem-2534	99	67	–	–	PUNCT
eurjchem-2534	99	68	cc	cc	NOUN
eurjchem-2534	99	69	by	by	ADP
eurjchem-2534	99	70	nc	nc	PROPN
eurjchem-2534	99	71	–	–	PUNCT
eurjchem-2534	99	72	doi	doi	PROPN
eurjchem-2534	99	73	:	:	PUNCT
eurjchem-2534	99	74	10.5155	10.5155	NUM
eurjchem-2534	99	75	/	/	SYM
eurjchem-2534	99	76	eurjchem.15.2.194	eurjchem.15.2.194	NUM
eurjchem-2534	99	77	-	-	PUNCT
eurjchem-2534	99	78	204.2534	204.2534	NUM
eurjchem-2534	99	79	figure	figure	NOUN
eurjchem-2534	99	80	4	4	NUM
eurjchem-2534	99	81	.	.	PUNCT
eurjchem-2534	100	1	chemical	chemical	NOUN
eurjchem-2534	100	2	structures	structure	NOUN
eurjchem-2534	100	3	of	of	ADP
eurjchem-2534	100	4	celastrol	celastrol	NOUN
eurjchem-2534	100	5	derivatives	derivative	NOUN
eurjchem-2534	100	6	2–15	2–15	PROPN
eurjchem-2534	100	7	,	,	PUNCT
eurjchem-2534	100	8	which	which	PRON
eurjchem-2534	100	9	have	have	AUX
eurjchem-2534	100	10	been	be	AUX
eurjchem-2534	100	11	modified	modify	VERB
eurjchem-2534	100	12	at	at	ADP
eurjchem-2534	100	13	the	the	DET
eurjchem-2534	100	14	c-29	c-29	PUNCT
eurjchem-2534	100	15	carboxyl	carboxyl	NOUN
eurjchem-2534	100	16	group	group	NOUN
eurjchem-2534	100	17	.	.	PUNCT
eurjchem-2534	101	1	this	this	DET
eurjchem-2534	101	2	figure	figure	NOUN
eurjchem-2534	101	3	illustrates	illustrate	VERB
eurjchem-2534	101	4	the	the	DET
eurjchem-2534	101	5	various	various	ADJ
eurjchem-2534	101	6	modifications	modification	NOUN
eurjchem-2534	101	7	made	make	VERB
eurjchem-2534	101	8	to	to	ADP
eurjchem-2534	101	9	the	the	DET
eurjchem-2534	101	10	chemical	chemical	NOUN
eurjchem-2534	101	11	structure	structure	NOUN
eurjchem-2534	101	12	of	of	ADP
eurjchem-2534	101	13	celastrol	celastrol	NOUN
eurjchem-2534	101	14	to	to	PART
eurjchem-2534	101	15	explore	explore	VERB
eurjchem-2534	101	16	its	its	PRON
eurjchem-2534	101	17	impact	impact	NOUN
eurjchem-2534	101	18	on	on	ADP
eurjchem-2534	101	19	the	the	DET
eurjchem-2534	101	20	pharmacological	pharmacological	ADJ
eurjchem-2534	101	21	properties	property	NOUN
eurjchem-2534	101	22	(	(	PUNCT
eurjchem-2534	101	23	i	i	NOUN
eurjchem-2534	101	24	)	)	PUNCT
eurjchem-2534	102	1	[	[	X
eurjchem-2534	102	2	28	28	NUM
eurjchem-2534	102	3	-	-	SYM
eurjchem-2534	102	4	32,36	32,36	NUM
eurjchem-2534	102	5	]	]	PUNCT
eurjchem-2534	102	6	.	.	PUNCT
eurjchem-2534	103	1	(	(	PUNCT
eurjchem-2534	103	2	iv	iv	X
eurjchem-2534	103	3	)	)	PUNCT
eurjchem-2534	103	4	modification	modification	NOUN
eurjchem-2534	103	5	of	of	ADP
eurjchem-2534	103	6	ring	ring	NOUN
eurjchem-2534	103	7	a	a	PRON
eurjchem-2534	103	8	:	:	PUNCT
eurjchem-2534	103	9	during	during	ADP
eurjchem-2534	103	10	the	the	DET
eurjchem-2534	103	11	lead	lead	ADJ
eurjchem-2534	103	12	compound	compound	NOUN
eurjchem-2534	103	13	screening	screening	NOUN
eurjchem-2534	103	14	for	for	ADP
eurjchem-2534	103	15	potential	potential	ADJ
eurjchem-2534	103	16	treatments	treatment	NOUN
eurjchem-2534	103	17	targeting	target	VERB
eurjchem-2534	103	18	neurodegenerative	neurodegenerative	ADJ
eurjchem-2534	103	19	diseases	disease	NOUN
eurjchem-2534	103	20	,	,	PUNCT
eurjchem-2534	103	21	westerheide	westerheide	ADJ
eurjchem-2534	103	22	and	and	CCONJ
eurjchem-2534	103	23	colleagues	colleague	NOUN
eurjchem-2534	103	24	identified	identify	VERB
eurjchem-2534	103	25	celastrol	celastrol	NOUN
eurjchem-2534	103	26	as	as	ADP
eurjchem-2534	103	27	a	a	DET
eurjchem-2534	103	28	stimulator	stimulator	NOUN
eurjchem-2534	103	29	of	of	ADP
eurjchem-2534	103	30	the	the	DET
eurjchem-2534	103	31	human	human	ADJ
eurjchem-2534	103	32	heat	heat	NOUN
eurjchem-2534	103	33	shock	shock	NOUN
eurjchem-2534	103	34	response	response	NOUN
eurjchem-2534	104	1	[	[	X
eurjchem-2534	104	2	37	37	NUM
eurjchem-2534	104	3	]	]	PUNCT
eurjchem-2534	104	4	.	.	PUNCT
eurjchem-2534	105	1	to	to	PART
eurjchem-2534	105	2	elucidate	elucidate	VERB
eurjchem-2534	105	3	the	the	DET
eurjchem-2534	105	4	structural	structural	ADJ
eurjchem-2534	105	5	specificity	specificity	NOUN
eurjchem-2534	105	6	of	of	ADP
eurjchem-2534	105	7	celastrol	celastrol	NOUN
eurjchem-2534	105	8	,	,	PUNCT
eurjchem-2534	105	9	they	they	PRON
eurjchem-2534	105	10	conducted	conduct	VERB
eurjchem-2534	105	11	additional	additional	ADJ
eurjchem-2534	105	12	experiments	experiment	NOUN
eurjchem-2534	105	13	to	to	PART
eurjchem-2534	105	14	evaluate	evaluate	VERB
eurjchem-2534	105	15	the	the	DET
eurjchem-2534	105	16	efficacy	efficacy	NOUN
eurjchem-2534	105	17	of	of	ADP
eurjchem-2534	105	18	various	various	ADJ
eurjchem-2534	105	19	derivatives	derivative	NOUN
eurjchem-2534	105	20	(	(	PUNCT
eurjchem-2534	105	21	at	at	ADP
eurjchem-2534	105	22	concentrations	concentration	NOUN
eurjchem-2534	105	23	of	of	ADP
eurjchem-2534	105	24	3	3	NUM
eurjchem-2534	105	25	and	and	CCONJ
eurjchem-2534	105	26	8	8	NUM
eurjchem-2534	105	27	mm	mm	NOUN
eurjchem-2534	105	28	)	)	PUNCT
eurjchem-2534	105	29	in	in	ADP
eurjchem-2534	105	30	activating	activate	VERB
eurjchem-2534	105	31	the	the	DET
eurjchem-2534	105	32	heat	heat	NOUN
eurjchem-2534	105	33	shock	shock	NOUN
eurjchem-2534	105	34	promoter	promoter	NOUN
eurjchem-2534	105	35	reporter	reporter	NOUN
eurjchem-2534	105	36	,	,	PUNCT
eurjchem-2534	105	37	in	in	ADP
eurjchem-2534	105	38	particular	particular	ADJ
eurjchem-2534	105	39	the	the	DET
eurjchem-2534	105	40	results	result	NOUN
eurjchem-2534	105	41	indicated	indicate	VERB
eurjchem-2534	105	42	that	that	SCONJ
eurjchem-2534	105	43	1	1	NUM
eurjchem-2534	105	44	and	and	CCONJ
eurjchem-2534	105	45	dihydrocelastrol	dihydrocelastrol	VERB
eurjchem-2534	105	46	diacetate	diacetate	NOUN
eurjchem-2534	105	47	23	23	NUM
eurjchem-2534	105	48	are	be	AUX
eurjchem-2534	105	49	all	all	ADV
eurjchem-2534	105	50	active	active	ADJ
eurjchem-2534	105	51	at	at	ADP
eurjchem-2534	105	52	3	3	NUM
eurjchem-2534	105	53	mm	mm	NOUN
eurjchem-2534	105	54	(	(	PUNCT
eurjchem-2534	105	55	figure	figure	NOUN
eurjchem-2534	105	56	5b	5b	NUM
eurjchem-2534	105	57	)	)	PUNCT
eurjchem-2534	105	58	.	.	PUNCT
eurjchem-2534	106	1	to	to	PART
eurjchem-2534	106	2	identify	identify	VERB
eurjchem-2534	106	3	celastrol	celastrol	NOUN
eurjchem-2534	106	4	derivatives	derivative	NOUN
eurjchem-2534	106	5	possessing	possess	VERB
eurjchem-2534	106	6	robust	robust	ADJ
eurjchem-2534	106	7	neuroprotective	neuroprotective	ADJ
eurjchem-2534	106	8	properties	property	NOUN
eurjchem-2534	106	9	while	while	SCONJ
eurjchem-2534	106	10	exhibiting	exhibit	VERB
eurjchem-2534	106	11	reduced	reduced	ADJ
eurjchem-2534	106	12	toxicity	toxicity	NOUN
eurjchem-2534	106	13	,	,	PUNCT
eurjchem-2534	106	14	sun	sun	NOUN
eurjchem-2534	106	15	and	and	CCONJ
eurjchem-2534	106	16	collaborators	collaborator	NOUN
eurjchem-2534	106	17	synthesized	synthesize	VERB
eurjchem-2534	106	18	a	a	DET
eurjchem-2534	106	19	range	range	NOUN
eurjchem-2534	106	20	of	of	ADP
eurjchem-2534	106	21	derivatives	derivative	NOUN
eurjchem-2534	106	22	modified	modify	VERB
eurjchem-2534	106	23	at	at	ADP
eurjchem-2534	106	24	the	the	DET
eurjchem-2534	106	25	c-2	c-2	NOUN
eurjchem-2534	106	26	,	,	PUNCT
eurjchem-2534	106	27	c-3	c-3	PROPN
eurjchem-2534	106	28	(	(	PUNCT
eurjchem-2534	106	29	figure	figure	NOUN
eurjchem-2534	106	30	5c	5c	NUM
eurjchem-2534	106	31	)	)	PUNCT
eurjchem-2534	107	1	[	[	X
eurjchem-2534	107	2	8	8	NUM
eurjchem-2534	107	3	]	]	PUNCT
eurjchem-2534	107	4	.	.	PUNCT
eurjchem-2534	108	1	2.2	2.2	NUM
eurjchem-2534	108	2	.	.	PUNCT
eurjchem-2534	109	1	triazole	triazole	ADJ
eurjchem-2534	109	2	derivatives	derivative	NOUN
eurjchem-2534	109	3	and	and	CCONJ
eurjchem-2534	109	4	click	click	VERB
eurjchem-2534	109	5	chemistry	chemistry	NOUN
eurjchem-2534	109	6	of	of	ADP
eurjchem-2534	109	7	celastrol	celastrol	NOUN
eurjchem-2534	109	8	triterpenoids	triterpenoids	PROPN
eurjchem-2534	109	9	,	,	PUNCT
eurjchem-2534	109	10	natural	natural	ADJ
eurjchem-2534	109	11	compounds	compound	NOUN
eurjchem-2534	109	12	renowned	renowne	VERB
eurjchem-2534	109	13	for	for	ADP
eurjchem-2534	109	14	their	their	PRON
eurjchem-2534	109	15	diverse	diverse	ADJ
eurjchem-2534	109	16	biological	biological	ADJ
eurjchem-2534	109	17	activities	activity	NOUN
eurjchem-2534	109	18	,	,	PUNCT
eurjchem-2534	109	19	exhibit	exhibit	VERB
eurjchem-2534	109	20	considerable	considerable	ADJ
eurjchem-2534	109	21	promise	promise	NOUN
eurjchem-2534	109	22	in	in	ADP
eurjchem-2534	109	23	therapeutic	therapeutic	ADJ
eurjchem-2534	109	24	applications	application	NOUN
eurjchem-2534	109	25	.	.	PUNCT
eurjchem-2534	110	1	despite	despite	SCONJ
eurjchem-2534	110	2	their	their	PRON
eurjchem-2534	110	3	advantageous	advantageous	ADJ
eurjchem-2534	110	4	low	low	ADJ
eurjchem-2534	110	5	toxicity	toxicity	NOUN
eurjchem-2534	110	6	and	and	CCONJ
eurjchem-2534	110	7	abundant	abundant	ADJ
eurjchem-2534	110	8	availability	availability	NOUN
eurjchem-2534	110	9	from	from	ADP
eurjchem-2534	110	10	natural	natural	ADJ
eurjchem-2534	110	11	sources	source	NOUN
eurjchem-2534	110	12	,	,	PUNCT
eurjchem-2534	110	13	their	their	PRON
eurjchem-2534	110	14	clinical	clinical	ADJ
eurjchem-2534	110	15	utility	utility	NOUN
eurjchem-2534	110	16	remains	remain	VERB
eurjchem-2534	110	17	restricted	restrict	VERB
eurjchem-2534	110	18	due	due	ADP
eurjchem-2534	110	19	to	to	ADP
eurjchem-2534	110	20	higher	high	ADJ
eurjchem-2534	110	21	ic50	ic50	PROPN
eurjchem-2534	110	22	values	value	NOUN
eurjchem-2534	110	23	and	and	CCONJ
eurjchem-2534	110	24	inferior	inferior	ADJ
eurjchem-2534	110	25	pharmacological	pharmacological	ADJ
eurjchem-2534	110	26	profiles	profile	NOUN
eurjchem-2534	110	27	compared	compare	VERB
eurjchem-2534	110	28	to	to	ADP
eurjchem-2534	110	29	established	establish	VERB
eurjchem-2534	110	30	therapeutics	therapeutic	NOUN
eurjchem-2534	110	31	.	.	PUNCT
eurjchem-2534	111	1	motivated	motivate	VERB
eurjchem-2534	111	2	by	by	ADP
eurjchem-2534	111	3	this	this	DET
eurjchem-2534	111	4	limitation	limitation	NOUN
eurjchem-2534	111	5	,	,	PUNCT
eurjchem-2534	111	6	numerous	numerous	ADJ
eurjchem-2534	111	7	researchhers	researchher	NOUN
eurjchem-2534	111	8	have	have	AUX
eurjchem-2534	111	9	embarked	embark	VERB
eurjchem-2534	111	10	on	on	ADP
eurjchem-2534	111	11	endeavors	endeavor	NOUN
eurjchem-2534	111	12	to	to	PART
eurjchem-2534	111	13	engineer	engineer	VERB
eurjchem-2534	111	14	novel	novel	ADJ
eurjchem-2534	111	15	terpenic	terpenic	ADJ
eurjchem-2534	111	16	derivatives	derivative	NOUN
eurjchem-2534	111	17	with	with	ADP
eurjchem-2534	111	18	enhanced	enhanced	ADJ
eurjchem-2534	111	19	pharmacological	pharmacological	ADJ
eurjchem-2534	111	20	properties	property	NOUN
eurjchem-2534	111	21	,	,	PUNCT
eurjchem-2534	111	22	aiming	aim	VERB
eurjchem-2534	111	23	to	to	PART
eurjchem-2534	111	24	unlock	unlock	VERB
eurjchem-2534	111	25	their	their	PRON
eurjchem-2534	111	26	full	full	ADJ
eurjchem-2534	111	27	potential	potential	NOUN
eurjchem-2534	111	28	for	for	ADP
eurjchem-2534	111	29	clinical	clinical	ADJ
eurjchem-2534	111	30	use	use	NOUN
eurjchem-2534	111	31	[	[	X
eurjchem-2534	111	32	38	38	NUM
eurjchem-2534	111	33	]	]	PUNCT
eurjchem-2534	111	34	.	.	PUNCT
eurjchem-2534	112	1	198	198	NUM
eurjchem-2534	112	2	ren	ren	NOUN
eurjchem-2534	112	3	and	and	CCONJ
eurjchem-2534	112	4	coghi	coghi	PROPN
eurjchem-2534	112	5	/	/	SYM
eurjchem-2534	112	6	european	european	PROPN
eurjchem-2534	112	7	journal	journal	PROPN
eurjchem-2534	112	8	of	of	ADP
eurjchem-2534	112	9	chemistry	chemistry	NOUN
eurjchem-2534	112	10	15	15	NUM
eurjchem-2534	112	11	(	(	PUNCT
eurjchem-2534	112	12	2	2	NUM
eurjchem-2534	112	13	)	)	PUNCT
eurjchem-2534	112	14	(	(	PUNCT
eurjchem-2534	112	15	2024	2024	NUM
eurjchem-2534	112	16	)	)	PUNCT
eurjchem-2534	112	17	194	194	NUM
eurjchem-2534	112	18	-	-	SYM
eurjchem-2534	112	19	204	204	NUM
eurjchem-2534	112	20	2024	2024	NUM
eurjchem-2534	112	21	–	–	PUNCT
eurjchem-2534	112	22	european	european	ADJ
eurjchem-2534	112	23	journal	journal	NOUN
eurjchem-2534	112	24	of	of	ADP
eurjchem-2534	112	25	chemistry	chemistry	NOUN
eurjchem-2534	112	26	–	–	PUNCT
eurjchem-2534	112	27	cc	cc	NOUN
eurjchem-2534	112	28	by	by	ADP
eurjchem-2534	112	29	nc	nc	PROPN
eurjchem-2534	112	30	–	–	PUNCT
eurjchem-2534	112	31	doi	doi	PROPN
eurjchem-2534	112	32	:	:	PUNCT
eurjchem-2534	112	33	10.5155	10.5155	NUM
eurjchem-2534	112	34	/	/	SYM
eurjchem-2534	112	35	eurjchem.15.2.194	eurjchem.15.2.194	NUM
eurjchem-2534	112	36	-	-	PUNCT
eurjchem-2534	112	37	204.2534	204.2534	NUM
eurjchem-2534	112	38	figure	figure	NOUN
eurjchem-2534	112	39	5	5	NUM
eurjchem-2534	112	40	.	.	PUNCT
eurjchem-2534	113	1	(	(	PUNCT
eurjchem-2534	113	2	a	a	X
eurjchem-2534	113	3	)	)	PUNCT
eurjchem-2534	113	4	celastrol	celastrol	NOUN
eurjchem-2534	113	5	derivatives	derivative	NOUN
eurjchem-2534	113	6	16,17	16,17	NUM
eurjchem-2534	113	7	chemically	chemically	ADV
eurjchem-2534	113	8	modified	modify	VERB
eurjchem-2534	113	9	by	by	ADP
eurjchem-2534	113	10	the	the	DET
eurjchem-2534	113	11	c-6	c-6	NOUN
eurjchem-2534	113	12	group	group	NOUN
eurjchem-2534	113	13	(	(	PUNCT
eurjchem-2534	113	14	ii	ii	NOUN
eurjchem-2534	113	15	)	)	PUNCT
eurjchem-2534	114	1	[	[	X
eurjchem-2534	114	2	33,35	33,35	NOUN
eurjchem-2534	114	3	]	]	X
eurjchem-2534	114	4	;	;	PUNCT
eurjchem-2534	114	5	(	(	PUNCT
eurjchem-2534	114	6	b	b	X
eurjchem-2534	114	7	)	)	PUNCT
eurjchem-2534	114	8	celastrol	celastrol	NOUN
eurjchem-2534	114	9	derivatives	derivative	NOUN
eurjchem-2534	114	10	chemically	chemically	ADV
eurjchem-2534	114	11	18–23	18–23	NUM
eurjchem-2534	114	12	modified	modify	VERB
eurjchem-2534	114	13	by	by	ADP
eurjchem-2534	114	14	the	the	DET
eurjchem-2534	114	15	c-3hydroxyl	c-3hydroxyl	PROPN
eurjchem-2534	114	16	group	group	NOUN
eurjchem-2534	115	1	[	[	X
eurjchem-2534	115	2	8,30	8,30	X
eurjchem-2534	115	3	]	]	X
eurjchem-2534	115	4	;	;	PUNCT
eurjchem-2534	115	5	(	(	PUNCT
eurjchem-2534	115	6	c	c	X
eurjchem-2534	115	7	)	)	PUNCT
eurjchem-2534	115	8	celastrol	celastrol	NOUN
eurjchem-2534	115	9	derivatives	derivative	NOUN
eurjchem-2534	115	10	chemically	chemically	ADV
eurjchem-2534	115	11	24	24	NUM
eurjchem-2534	115	12	,	,	PUNCT
eurjchem-2534	115	13	25	25	NUM
eurjchem-2534	115	14	modified	modify	VERB
eurjchem-2534	115	15	at	at	ADP
eurjchem-2534	115	16	ring	ring	NOUN
eurjchem-2534	115	17	a	a	PRON
eurjchem-2534	115	18	[	[	X
eurjchem-2534	115	19	37	37	NUM
eurjchem-2534	115	20	]	]	PUNCT
eurjchem-2534	115	21	.	.	PUNCT
eurjchem-2534	116	1	in	in	ADP
eurjchem-2534	116	2	recent	recent	ADJ
eurjchem-2534	116	3	years	year	NOUN
eurjchem-2534	116	4	,	,	PUNCT
eurjchem-2534	116	5	significant	significant	ADJ
eurjchem-2534	116	6	exploration	exploration	NOUN
eurjchem-2534	116	7	has	have	AUX
eurjchem-2534	116	8	been	be	AUX
eurjchem-2534	116	9	conducted	conduct	VERB
eurjchem-2534	116	10	in	in	ADP
eurjchem-2534	116	11	improving	improve	VERB
eurjchem-2534	116	12	the	the	DET
eurjchem-2534	116	13	activity	activity	NOUN
eurjchem-2534	116	14	and	and	CCONJ
eurjchem-2534	116	15	adme	adme	NOUN
eurjchem-2534	116	16	-	-	PUNCT
eurjchem-2534	116	17	tox	tox	NOUN
eurjchem-2534	116	18	properties	property	NOUN
eurjchem-2534	116	19	of	of	ADP
eurjchem-2534	116	20	terpenes	terpene	NOUN
eurjchem-2534	116	21	by	by	ADP
eurjchem-2534	116	22	linking	link	VERB
eurjchem-2534	116	23	them	they	PRON
eurjchem-2534	116	24	to	to	ADP
eurjchem-2534	116	25	modifying	modify	VERB
eurjchem-2534	116	26	molecules	molecule	NOUN
eurjchem-2534	116	27	through	through	ADP
eurjchem-2534	116	28	click	click	VERB
eurjchem-2534	116	29	reactions	reaction	NOUN
eurjchem-2534	116	30	.	.	PUNCT
eurjchem-2534	117	1	this	this	DET
eurjchem-2534	117	2	synthetic	synthetic	ADJ
eurjchem-2534	117	3	strategy	strategy	NOUN
eurjchem-2534	117	4	has	have	AUX
eurjchem-2534	117	5	shown	show	VERB
eurjchem-2534	117	6	promising	promising	ADJ
eurjchem-2534	117	7	advancements	advancement	NOUN
eurjchem-2534	117	8	,	,	PUNCT
eurjchem-2534	117	9	leading	lead	VERB
eurjchem-2534	117	10	to	to	ADP
eurjchem-2534	117	11	notable	notable	ADJ
eurjchem-2534	117	12	improvements	improvement	NOUN
eurjchem-2534	117	13	in	in	ADP
eurjchem-2534	117	14	the	the	DET
eurjchem-2534	117	15	parent	parent	NOUN
eurjchem-2534	117	16	compounds	compound	VERB
eurjchem-2534	117	17	.	.	PUNCT
eurjchem-2534	118	1	the	the	DET
eurjchem-2534	118	2	prominent	prominent	ADJ
eurjchem-2534	118	3	cu(i	cu(i	NOUN
eurjchem-2534	118	4	)	)	PUNCT
eurjchem-2534	118	5	(	(	PUNCT
eurjchem-2534	118	6	copper)-catalyzed	copper)-catalyze	VERB
eurjchem-2534	118	7	azide	azide	NOUN
eurjchem-2534	118	8	–	–	PUNCT
eurjchem-2534	118	9	alkyne	alkyne	NOUN
eurjchem-2534	118	10	cycloaddition	cycloaddition	NOUN
eurjchem-2534	118	11	(	(	PUNCT
eurjchem-2534	118	12	cuaac	cuaac	NOUN
eurjchem-2534	118	13	,	,	PUNCT
eurjchem-2534	118	14	click	click	VERB
eurjchem-2534	118	15	chemistry	chemistry	NOUN
eurjchem-2534	118	16	,	,	PUNCT
eurjchem-2534	118	17	figures	figure	VERB
eurjchem-2534	118	18	6a	6a	NOUN
eurjchem-2534	118	19	and	and	CCONJ
eurjchem-2534	118	20	6b	6b	NUM
eurjchem-2534	118	21	)	)	PUNCT
eurjchem-2534	118	22	,	,	PUNCT
eurjchem-2534	118	23	discovered	discover	VERB
eurjchem-2534	118	24	independently	independently	ADV
eurjchem-2534	118	25	by	by	ADP
eurjchem-2534	118	26	meldal	meldal	PROPN
eurjchem-2534	118	27	et	et	PROPN
eurjchem-2534	118	28	al	al	PROPN
eurjchem-2534	118	29	.	.	PUNCT
eurjchem-2534	119	1	[	[	X
eurjchem-2534	119	2	39	39	NUM
eurjchem-2534	119	3	]	]	PUNCT
eurjchem-2534	119	4	and	and	CCONJ
eurjchem-2534	119	5	sharpless	sharpless	NOUN
eurjchem-2534	119	6	et	et	PROPN
eurjchem-2534	119	7	al	al	PROPN
eurjchem-2534	119	8	.	.	PUNCT
eurjchem-2534	120	1	[	[	X
eurjchem-2534	120	2	40	40	NUM
eurjchem-2534	120	3	]	]	PUNCT
eurjchem-2534	120	4	,	,	PUNCT
eurjchem-2534	120	5	is	be	AUX
eurjchem-2534	120	6	the	the	DET
eurjchem-2534	120	7	most	most	ADV
eurjchem-2534	120	8	common	common	ADJ
eurjchem-2534	120	9	and	and	CCONJ
eurjchem-2534	120	10	promising	promising	ADJ
eurjchem-2534	120	11	approaches	approach	NOUN
eurjchem-2534	120	12	that	that	PRON
eurjchem-2534	120	13	are	be	AUX
eurjchem-2534	120	14	used	use	VERB
eurjchem-2534	120	15	to	to	PART
eurjchem-2534	120	16	produce	produce	VERB
eurjchem-2534	120	17	the	the	DET
eurjchem-2534	120	18	most	most	ADV
eurjchem-2534	120	19	efficiently	efficiently	ADV
eurjchem-2534	120	20	in	in	ADP
eurjchem-2534	120	21	the	the	DET
eurjchem-2534	120	22	synthesis	synthesis	NOUN
eurjchem-2534	120	23	of	of	ADP
eurjchem-2534	120	24	various	various	ADJ
eurjchem-2534	120	25	1,2,3	1,2,3	NUM
eurjchem-2534	120	26	-	-	PUNCT
eurjchem-2534	120	27	triazoles	triazole	NOUN
eurjchem-2534	120	28	[	[	X
eurjchem-2534	120	29	41	41	NUM
eurjchem-2534	120	30	]	]	PUNCT
eurjchem-2534	120	31	(	(	PUNCT
eurjchem-2534	120	32	figure	figure	VERB
eurjchem-2534	120	33	6a	6a	NOUN
eurjchem-2534	120	34	and	and	CCONJ
eurjchem-2534	120	35	6b	6b	NUM
eurjchem-2534	120	36	)	)	PUNCT
eurjchem-2534	120	37	.	.	PUNCT
eurjchem-2534	121	1	the	the	DET
eurjchem-2534	121	2	nobel	nobel	PROPN
eurjchem-2534	121	3	prize	prize	PROPN
eurjchem-2534	121	4	in	in	ADP
eurjchem-2534	121	5	chemistry	chemistry	NOUN
eurjchem-2534	121	6	2022	2022	NUM
eurjchem-2534	121	7	was	be	AUX
eurjchem-2534	121	8	awarded	award	VERB
eurjchem-2534	121	9	jointly	jointly	ADV
eurjchem-2534	121	10	to	to	ADP
eurjchem-2534	121	11	carolyn	carolyn	PROPN
eurjchem-2534	121	12	r.	r.	PROPN
eurjchem-2534	121	13	bertozzi	bertozzi	PROPN
eurjchem-2534	121	14	,	,	PUNCT
eurjchem-2534	121	15	morten	morten	PROPN
eurjchem-2534	121	16	meldal	meldal	NOUN
eurjchem-2534	121	17	,	,	PUNCT
eurjchem-2534	121	18	and	and	CCONJ
eurjchem-2534	121	19	k.	k.	PROPN
eurjchem-2534	121	20	barry	barry	PROPN
eurjchem-2534	121	21	sharpless	sharpless	PROPN
eurjchem-2534	121	22	for	for	ADP
eurjchem-2534	121	23	the	the	DET
eurjchem-2534	121	24	development	development	NOUN
eurjchem-2534	121	25	of	of	ADP
eurjchem-2534	121	26	click	click	VERB
eurjchem-2534	121	27	chemistry	chemistry	NOUN
eurjchem-2534	121	28	and	and	CCONJ
eurjchem-2534	121	29	bioorthogonal	bioorthogonal	ADJ
eurjchem-2534	121	30	chemistry	chemistry	NOUN
eurjchem-2534	121	31	[	[	X
eurjchem-2534	121	32	42	42	NUM
eurjchem-2534	121	33	]	]	PUNCT
eurjchem-2534	121	34	.	.	PUNCT
eurjchem-2534	122	1	the	the	DET
eurjchem-2534	122	2	1,2,3triazole	1,2,3triazole	NUM
eurjchem-2534	122	3	core	core	NOUN
eurjchem-2534	122	4	can	can	AUX
eurjchem-2534	122	5	form	form	VERB
eurjchem-2534	122	6	π	π	PROPN
eurjchem-2534	122	7	-	-	PUNCT
eurjchem-2534	122	8	π	π	ADJ
eurjchem-2534	122	9	interaction	interaction	NOUN
eurjchem-2534	122	10	with	with	ADP
eurjchem-2534	122	11	aromatic	aromatic	ADJ
eurjchem-2534	122	12	rings	ring	NOUN
eurjchem-2534	122	13	such	such	ADJ
eurjchem-2534	122	14	as	as	ADP
eurjchem-2534	122	15	the	the	DET
eurjchem-2534	122	16	phenyl	phenyl	NOUN
eurjchem-2534	122	17	ring	ring	NOUN
eurjchem-2534	122	18	of	of	ADP
eurjchem-2534	122	19	amino	amino	ADJ
eurjchem-2534	122	20	acids	acid	NOUN
eurjchem-2534	122	21	in	in	ADP
eurjchem-2534	122	22	targets	target	NOUN
eurjchem-2534	122	23	.	.	PUNCT
eurjchem-2534	123	1	their	their	PRON
eurjchem-2534	123	2	unique	unique	ADJ
eurjchem-2534	123	3	structural	structural	ADJ
eurjchem-2534	123	4	characteristics	characteristic	NOUN
eurjchem-2534	123	5	,	,	PUNCT
eurjchem-2534	123	6	including	include	VERB
eurjchem-2534	123	7	their	their	PRON
eurjchem-2534	123	8	polarity	polarity	NOUN
eurjchem-2534	123	9	,	,	PUNCT
eurjchem-2534	123	10	dipole	dipole	NOUN
eurjchem-2534	123	11	moment	moment	NOUN
eurjchem-2534	123	12	,	,	PUNCT
eurjchem-2534	123	13	rigidity	rigidity	NOUN
eurjchem-2534	123	14	,	,	PUNCT
eurjchem-2534	123	15	and	and	CCONJ
eurjchem-2534	123	16	ability	ability	NOUN
eurjchem-2534	123	17	to	to	PART
eurjchem-2534	123	18	function	function	VERB
eurjchem-2534	123	19	as	as	ADP
eurjchem-2534	123	20	both	both	DET
eurjchem-2534	123	21	hydrogen	hydrogen	NOUN
eurjchem-2534	123	22	bond	bond	NOUN
eurjchem-2534	123	23	donors	donor	NOUN
eurjchem-2534	123	24	(	(	PUNCT
eurjchem-2534	123	25	hbds	hbds	NOUN
eurjchem-2534	123	26	)	)	PUNCT
eurjchem-2534	123	27	and	and	CCONJ
eurjchem-2534	123	28	hydrogen	hydrogen	NOUN
eurjchem-2534	123	29	bond	bond	NOUN
eurjchem-2534	123	30	acceptors	acceptor	NOUN
eurjchem-2534	123	31	(	(	PUNCT
eurjchem-2534	123	32	hbas	hbas	PROPN
eurjchem-2534	123	33	)	)	PUNCT
eurjchem-2534	123	34	,	,	PUNCT
eurjchem-2534	123	35	allow	allow	VERB
eurjchem-2534	123	36	them	they	PRON
eurjchem-2534	123	37	to	to	PART
eurjchem-2534	123	38	mimic	mimic	VERB
eurjchem-2534	123	39	a	a	DET
eurjchem-2534	123	40	variety	variety	NOUN
eurjchem-2534	123	41	of	of	ADP
eurjchem-2534	123	42	functional	functional	ADJ
eurjchem-2534	123	43	groups	group	NOUN
eurjchem-2534	123	44	while	while	SCONJ
eurjchem-2534	123	45	offering	offer	VERB
eurjchem-2534	123	46	significant	significant	ADJ
eurjchem-2534	123	47	stability	stability	NOUN
eurjchem-2534	123	48	against	against	ADP
eurjchem-2534	123	49	hydrolytic	hydrolytic	ADJ
eurjchem-2534	123	50	,	,	PUNCT
eurjchem-2534	123	51	oxidative	oxidative	ADJ
eurjchem-2534	123	52	,	,	PUNCT
eurjchem-2534	123	53	and	and	CCONJ
eurjchem-2534	123	54	reductive	reductive	ADJ
eurjchem-2534	123	55	conditions	condition	NOUN
eurjchem-2534	123	56	.	.	PUNCT
eurjchem-2534	124	1	these	these	DET
eurjchem-2534	124	2	compounds	compound	NOUN
eurjchem-2534	124	3	generally	generally	ADV
eurjchem-2534	124	4	withstand	withstand	VERB
eurjchem-2534	124	5	hydrolysis	hydrolysis	NOUN
eurjchem-2534	124	6	in	in	ADP
eurjchem-2534	124	7	both	both	CCONJ
eurjchem-2534	124	8	acidic	acidic	ADJ
eurjchem-2534	124	9	and	and	CCONJ
eurjchem-2534	124	10	basic	basic	ADJ
eurjchem-2534	124	11	environments	environment	NOUN
eurjchem-2534	124	12	,	,	PUNCT
eurjchem-2534	124	13	as	as	ADV
eurjchem-2534	124	14	well	well	ADV
eurjchem-2534	124	15	as	as	ADP
eurjchem-2534	124	16	remain	remain	VERB
eurjchem-2534	124	17	stable	stable	ADJ
eurjchem-2534	124	18	in	in	ADP
eurjchem-2534	124	19	oxidative	oxidative	ADJ
eurjchem-2534	124	20	-	-	PUNCT
eurjchem-2534	124	21	reductive	reductive	ADJ
eurjchem-2534	124	22	conditions	condition	NOUN
eurjchem-2534	124	23	,	,	PUNCT
eurjchem-2534	124	24	indicating	indicate	VERB
eurjchem-2534	124	25	high	high	ADJ
eurjchem-2534	124	26	resistance	resistance	NOUN
eurjchem-2534	124	27	to	to	ADP
eurjchem-2534	124	28	metabolic	metabolic	NOUN
eurjchem-2534	124	29	degradation	degradation	NOUN
eurjchem-2534	124	30	and	and	CCONJ
eurjchem-2534	124	31	substantial	substantial	ADJ
eurjchem-2534	124	32	aromatic	aromatic	ADJ
eurjchem-2534	124	33	stabilization	stabilization	NOUN
eurjchem-2534	124	34	.	.	PUNCT
eurjchem-2534	125	1	in	in	ADP
eurjchem-2534	125	2	particular	particular	ADJ
eurjchem-2534	125	3	,	,	PUNCT
eurjchem-2534	125	4	1,2,3	1,2,3	NUM
eurjchem-2534	125	5	-	-	PUNCT
eurjchem-2534	125	6	triazoles	triazole	NOUN
eurjchem-2534	125	7	are	be	AUX
eurjchem-2534	125	8	among	among	ADP
eurjchem-2534	125	9	the	the	DET
eurjchem-2534	125	10	most	most	ADV
eurjchem-2534	125	11	prevalent	prevalent	ADJ
eurjchem-2534	125	12	amide	amide	NOUN
eurjchem-2534	125	13	/	/	SYM
eurjchem-2534	125	14	guanidine	guanidine	NOUN
eurjchem-2534	125	15	isosteres	isostere	NOUN
eurjchem-2534	125	16	.	.	PUNCT
eurjchem-2534	126	1	their	their	PRON
eurjchem-2534	126	2	structural	structural	ADJ
eurjchem-2534	126	3	attributes	attribute	NOUN
eurjchem-2534	126	4	allow	allow	VERB
eurjchem-2534	126	5	them	they	PRON
eurjchem-2534	126	6	to	to	PART
eurjchem-2534	126	7	closely	closely	ADV
eurjchem-2534	126	8	resemble	resemble	VERB
eurjchem-2534	126	9	amide	amide	NOUN
eurjchem-2534	126	10	-	-	PUNCT
eurjchem-2534	126	11	binding	bind	VERB
eurjchem-2534	126	12	groups	group	NOUN
eurjchem-2534	126	13	,	,	PUNCT
eurjchem-2534	126	14	facilitating	facilitate	VERB
eurjchem-2534	126	15	effective	effective	ADJ
eurjchem-2534	126	16	interaction	interaction	NOUN
eurjchem-2534	126	17	with	with	ADP
eurjchem-2534	126	18	various	various	ADJ
eurjchem-2534	126	19	targets	target	NOUN
eurjchem-2534	126	20	.	.	PUNCT
eurjchem-2534	127	1	the	the	DET
eurjchem-2534	127	2	click	click	NOUN
eurjchem-2534	127	3	chemistry	chemistry	NOUN
eurjchem-2534	127	4	strategy	strategy	NOUN
eurjchem-2534	127	5	was	be	AUX
eurjchem-2534	127	6	also	also	ADV
eurjchem-2534	127	7	adopted	adopt	VERB
eurjchem-2534	127	8	for	for	ADP
eurjchem-2534	127	9	the	the	DET
eurjchem-2534	127	10	structure	structure	NOUN
eurjchem-2534	127	11	modification	modification	NOUN
eurjchem-2534	127	12	of	of	ADP
eurjchem-2534	127	13	cel	cel	PROPN
eurjchem-2534	127	14	c-3	c-3	PROPN
eurjchem-2534	128	1	oh	oh	INTJ
eurjchem-2534	128	2	(	(	PUNCT
eurjchem-2534	128	3	figure	figure	NOUN
eurjchem-2534	128	4	7a	7a	NUM
eurjchem-2534	128	5	)	)	PUNCT
eurjchem-2534	128	6	.	.	PUNCT
eurjchem-2534	129	1	zhang	zhang	PROPN
eurjchem-2534	129	2	et	et	PROPN
eurjchem-2534	129	3	al	al	PROPN
eurjchem-2534	129	4	.	.	PROPN
eurjchem-2534	129	5	synthesized	synthesize	VERB
eurjchem-2534	129	6	by	by	ADP
eurjchem-2534	129	7	modifying	modify	VERB
eurjchem-2534	129	8	carboxylic	carboxylic	ADJ
eurjchem-2534	129	9	acid	acid	NOUN
eurjchem-2534	129	10	at	at	ADP
eurjchem-2534	129	11	the	the	DET
eurjchem-2534	129	12	20th	20th	ADJ
eurjchem-2534	129	13	position	position	NOUN
eurjchem-2534	129	14	with	with	ADP
eurjchem-2534	129	15	amino	amino	NOUN
eurjchem-2534	129	16	acid	acid	NOUN
eurjchem-2534	129	17	,	,	PUNCT
eurjchem-2534	129	18	amine	amine	NOUN
eurjchem-2534	129	19	,	,	PUNCT
eurjchem-2534	129	20	and	and	CCONJ
eurjchem-2534	129	21	triazole	triazole	NOUN
eurjchem-2534	129	22	derivatives	derivative	NOUN
eurjchem-2534	129	23	[	[	X
eurjchem-2534	129	24	43	43	NUM
eurjchem-2534	129	25	]	]	PUNCT
eurjchem-2534	129	26	.	.	PUNCT
eurjchem-2534	130	1	ren	ren	PROPN
eurjchem-2534	130	2	and	and	CCONJ
eurjchem-2534	130	3	coghi	coghi	PROPN
eurjchem-2534	130	4	/	/	SYM
eurjchem-2534	130	5	european	european	PROPN
eurjchem-2534	130	6	journal	journal	PROPN
eurjchem-2534	130	7	of	of	ADP
eurjchem-2534	130	8	chemistry	chemistry	NOUN
eurjchem-2534	130	9	15	15	NUM
eurjchem-2534	130	10	(	(	PUNCT
eurjchem-2534	130	11	2	2	NUM
eurjchem-2534	130	12	)	)	PUNCT
eurjchem-2534	130	13	(	(	PUNCT
eurjchem-2534	130	14	2024	2024	NUM
eurjchem-2534	130	15	)	)	PUNCT
eurjchem-2534	130	16	194	194	NUM
eurjchem-2534	130	17	-	-	SYM
eurjchem-2534	130	18	204	204	NUM
eurjchem-2534	130	19	199	199	NUM
eurjchem-2534	130	20	2024	2024	NUM
eurjchem-2534	130	21	–	–	PUNCT
eurjchem-2534	130	22	european	european	ADJ
eurjchem-2534	130	23	journal	journal	NOUN
eurjchem-2534	130	24	of	of	ADP
eurjchem-2534	130	25	chemistry	chemistry	NOUN
eurjchem-2534	130	26	–	–	PUNCT
eurjchem-2534	130	27	cc	cc	NOUN
eurjchem-2534	130	28	by	by	ADP
eurjchem-2534	130	29	nc	nc	PROPN
eurjchem-2534	130	30	–	–	PUNCT
eurjchem-2534	130	31	doi	doi	PROPN
eurjchem-2534	130	32	:	:	PUNCT
eurjchem-2534	130	33	10.5155	10.5155	NUM
eurjchem-2534	130	34	/	/	SYM
eurjchem-2534	130	35	eurjchem.15.2.194	eurjchem.15.2.194	NOUN
eurjchem-2534	130	36	-	-	PUNCT
eurjchem-2534	130	37	204.2534	204.2534	NUM
eurjchem-2534	130	38	n	n	CCONJ
eurjchem-2534	130	39	n	n	CCONJ
eurjchem-2534	130	40	n	n	CCONJ
eurjchem-2534	130	41	n	n	CCONJ
eurjchem-2534	130	42	n	n	PRON
eurjchem-2534	130	43	n(a	n(a	NUM
eurjchem-2534	130	44	)	)	PUNCT
eurjchem-2534	130	45	(	(	PUNCT
eurjchem-2534	130	46	b	b	X
eurjchem-2534	130	47	)	)	PUNCT
eurjchem-2534	130	48	r	r	NOUN
eurjchem-2534	130	49	h	h	NOUN
eurjchem-2534	131	1	[	[	X
eurjchem-2534	131	2	cu	cu	X
eurjchem-2534	131	3	]	]	X
eurjchem-2534	131	4	r	r	NOUN
eurjchem-2534	131	5	h	h	NOUN
eurjchem-2534	132	1	[	[	X
eurjchem-2534	132	2	cu	cu	X
eurjchem-2534	132	3	]	]	X
eurjchem-2534	132	4	r	r	NOUN
eurjchem-2534	132	5	cu	cu	PROPN
eurjchem-2534	133	1	[	[	X
eurjchem-2534	133	2	cu	cu	X
eurjchem-2534	133	3	]	]	X
eurjchem-2534	134	1	[	[	X
eurjchem-2534	134	2	cu	cu	X
eurjchem-2534	134	3	]	]	X
eurjchem-2534	134	4	h+	h+	X
eurjchem-2534	134	5	n3	n3	PROPN
eurjchem-2534	134	6	r	r	NOUN
eurjchem-2534	134	7	'	'	PUNCT
eurjchem-2534	134	8	r	r	NOUN
eurjchem-2534	134	9	cu	cu	NOUN
eurjchem-2534	134	10	[	[	X
eurjchem-2534	134	11	cu	cu	X
eurjchem-2534	134	12	]	]	X
eurjchem-2534	134	13	n	n	CCONJ
eurjchem-2534	134	14	n	n	CCONJ
eurjchem-2534	134	15	nh	nh	NOUN
eurjchem-2534	134	16	r	r	NOUN
eurjchem-2534	134	17	n	n	CCONJ
eurjchem-2534	134	18	n	n	CCONJ
eurjchem-2534	134	19	n	n	ADV
eurjchem-2534	134	20	r	r	NOUN
eurjchem-2534	134	21	'	'	PUNCT
eurjchem-2534	134	22	[	[	X
eurjchem-2534	134	23	cu	cu	X
eurjchem-2534	134	24	]	]	X
eurjchem-2534	135	1	[	[	X
eurjchem-2534	135	2	cu	cu	X
eurjchem-2534	135	3	]	]	X
eurjchem-2534	135	4	n	n	CCONJ
eurjchem-2534	135	5	n	n	CCONJ
eurjchem-2534	135	6	n	n	NOUN
eurjchem-2534	135	7	[	[	X
eurjchem-2534	135	8	cu	cu	X
eurjchem-2534	135	9	]	]	X
eurjchem-2534	135	10	r	r	NOUN
eurjchem-2534	135	11	r	r	NOUN
eurjchem-2534	135	12	'	'	PUNCT
eurjchem-2534	135	13	[	[	X
eurjchem-2534	135	14	cu	cu	X
eurjchem-2534	135	15	]	]	X
eurjchem-2534	135	16	r	r	X
eurjchem-2534	135	17	'	'	PUNCT
eurjchem-2534	135	18	h+	h+	PUNCT
eurjchem-2534	135	19	n	n	CCONJ
eurjchem-2534	135	20	n	n	CCONJ
eurjchem-2534	135	21	n	n	NOUN
eurjchem-2534	135	22	r	r	NOUN
eurjchem-2534	135	23	r	r	NOUN
eurjchem-2534	135	24	'	'	PUNCT
eurjchem-2534	135	25	h	h	NOUN
eurjchem-2534	135	26	figure	figure	NOUN
eurjchem-2534	135	27	6	6	NUM
eurjchem-2534	135	28	.	.	PUNCT
eurjchem-2534	136	1	(	(	PUNCT
eurjchem-2534	136	2	a	a	X
eurjchem-2534	136	3	)	)	PUNCT
eurjchem-2534	136	4	schematic	schematic	ADJ
eurjchem-2534	136	5	representation	representation	NOUN
eurjchem-2534	136	6	of	of	ADP
eurjchem-2534	136	7	click	click	VERB
eurjchem-2534	136	8	chemistry	chemistry	NOUN
eurjchem-2534	136	9	and	and	CCONJ
eurjchem-2534	136	10	(	(	PUNCT
eurjchem-2534	136	11	b	b	NOUN
eurjchem-2534	136	12	)	)	PUNCT
eurjchem-2534	136	13	mechanism	mechanism	NOUN
eurjchem-2534	136	14	of	of	ADP
eurjchem-2534	136	15	the	the	DET
eurjchem-2534	136	16	copper	copper	NOUN
eurjchem-2534	136	17	-	-	PUNCT
eurjchem-2534	136	18	catalyzed	catalyze	VERB
eurjchem-2534	136	19	azide	azide	NOUN
eurjchem-2534	136	20	-	-	PUNCT
eurjchem-2534	136	21	alkyne	alkyne	NOUN
eurjchem-2534	136	22	cycloaddition	cycloaddition	NOUN
eurjchem-2534	136	23	(	(	PUNCT
eurjchem-2534	136	24	cuaac	cuaac	NOUN
eurjchem-2534	136	25	)	)	PUNCT
eurjchem-2534	136	26	.	.	PUNCT
eurjchem-2534	137	1	the	the	DET
eurjchem-2534	137	2	diagram	diagram	NOUN
eurjchem-2534	137	3	shows	show	VERB
eurjchem-2534	137	4	the	the	DET
eurjchem-2534	137	5	copper(i)-catalyzed	copper(i)-catalyzed	ADJ
eurjchem-2534	137	6	azide	azide	NOUN
eurjchem-2534	137	7	-	-	PUNCT
eurjchem-2534	137	8	alkyne	alkyne	NOUN
eurjchem-2534	137	9	cycloaddition	cycloaddition	NOUN
eurjchem-2534	137	10	(	(	PUNCT
eurjchem-2534	137	11	cuaac	cuaac	NOUN
eurjchem-2534	137	12	)	)	PUNCT
eurjchem-2534	137	13	process	process	NOUN
eurjchem-2534	137	14	,	,	PUNCT
eurjchem-2534	137	15	demonstrating	demonstrate	VERB
eurjchem-2534	137	16	the	the	DET
eurjchem-2534	137	17	formation	formation	NOUN
eurjchem-2534	137	18	of	of	ADP
eurjchem-2534	137	19	1,2,3	1,2,3	NUM
eurjchem-2534	137	20	-	-	NOUN
eurjchem-2534	137	21	triazoles	triazole	NOUN
eurjchem-2534	137	22	from	from	ADP
eurjchem-2534	137	23	azide	azide	NOUN
eurjchem-2534	137	24	and	and	CCONJ
eurjchem-2534	137	25	alkyne	alkyne	NOUN
eurjchem-2534	137	26	reactants	reactant	NOUN
eurjchem-2534	137	27	.	.	PUNCT
eurjchem-2534	138	1	recently	recently	ADV
eurjchem-2534	138	2	,	,	PUNCT
eurjchem-2534	138	3	the	the	DET
eurjchem-2534	138	4	click	click	NOUN
eurjchem-2534	138	5	chemistry	chemistry	NOUN
eurjchem-2534	138	6	modification	modification	NOUN
eurjchem-2534	138	7	strategy	strategy	NOUN
eurjchem-2534	138	8	was	be	AUX
eurjchem-2534	138	9	successfully	successfully	ADV
eurjchem-2534	138	10	applied	apply	VERB
eurjchem-2534	138	11	to	to	ADP
eurjchem-2534	138	12	the	the	DET
eurjchem-2534	138	13	structure	structure	NOUN
eurjchem-2534	138	14	modification	modification	NOUN
eurjchem-2534	138	15	of	of	ADP
eurjchem-2534	138	16	the	the	DET
eurjchem-2534	138	17	c-28	c-28	ADJ
eurjchem-2534	138	18	carboxylic	carboxylic	ADJ
eurjchem-2534	138	19	group	group	NOUN
eurjchem-2534	138	20	of	of	ADP
eurjchem-2534	138	21	c-20	c-20	PROPN
eurjchem-2534	138	22	carboxylic	carboxylic	NOUN
eurjchem-2534	138	23	group	group	NOUN
eurjchem-2534	138	24	of	of	ADP
eurjchem-2534	138	25	compound	compound	NOUN
eurjchem-2534	138	26	1	1	NUM
eurjchem-2534	138	27	,	,	PUNCT
eurjchem-2534	138	28	and	and	CCONJ
eurjchem-2534	138	29	the	the	DET
eurjchem-2534	138	30	obtained	obtain	VERB
eurjchem-2534	138	31	celastrol-1,2,3	celastrol-1,2,3	NOUN
eurjchem-2534	138	32	-	-	PUNCT
eurjchem-2534	138	33	triazole	triazole	ADJ
eurjchem-2534	138	34	derivatives	derivative	NOUN
eurjchem-2534	138	35	that	that	PRON
eurjchem-2534	138	36	exhibited	exhibit	VERB
eurjchem-2534	138	37	potent	potent	ADJ
eurjchem-2534	138	38	anticancer	anticancer	NOUN
eurjchem-2534	138	39	activities	activity	NOUN
eurjchem-2534	138	40	(	(	PUNCT
eurjchem-2534	138	41	figure	figure	NOUN
eurjchem-2534	138	42	7b	7b	NUM
eurjchem-2534	138	43	)	)	PUNCT
eurjchem-2534	139	1	[	[	X
eurjchem-2534	139	2	44	44	NUM
eurjchem-2534	139	3	]	]	PUNCT
eurjchem-2534	139	4	.	.	PUNCT
eurjchem-2534	140	1	3	3	X
eurjchem-2534	140	2	.	.	X
eurjchem-2534	140	3	drug	drug	NOUN
eurjchem-2534	140	4	delivery	delivery	NOUN
eurjchem-2534	140	5	of	of	ADP
eurjchem-2534	140	6	celastrol	celastrol	NOUN
eurjchem-2534	140	7	celastrol	celastrol	NOUN
eurjchem-2534	140	8	,	,	PUNCT
eurjchem-2534	140	9	a	a	DET
eurjchem-2534	140	10	natural	natural	ADJ
eurjchem-2534	140	11	compound	compound	NOUN
eurjchem-2534	140	12	derived	derive	VERB
eurjchem-2534	140	13	from	from	ADP
eurjchem-2534	140	14	the	the	DET
eurjchem-2534	140	15	thunder	thunder	NOUN
eurjchem-2534	140	16	god	god	PROPN
eurjchem-2534	140	17	vine	vine	NOUN
eurjchem-2534	140	18	,	,	PUNCT
eurjchem-2534	140	19	has	have	AUX
eurjchem-2534	140	20	garnered	garner	VERB
eurjchem-2534	140	21	significant	significant	ADJ
eurjchem-2534	140	22	attention	attention	NOUN
eurjchem-2534	140	23	because	because	SCONJ
eurjchem-2534	140	24	of	of	ADP
eurjchem-2534	140	25	its	its	PRON
eurjchem-2534	140	26	potential	potential	NOUN
eurjchem-2534	140	27	to	to	PART
eurjchem-2534	140	28	treat	treat	VERB
eurjchem-2534	140	29	a	a	DET
eurjchem-2534	140	30	variety	variety	NOUN
eurjchem-2534	140	31	of	of	ADP
eurjchem-2534	140	32	diseases	disease	NOUN
eurjchem-2534	140	33	,	,	PUNCT
eurjchem-2534	140	34	such	such	ADJ
eurjchem-2534	140	35	as	as	ADP
eurjchem-2534	140	36	cancer	cancer	NOUN
eurjchem-2534	140	37	,	,	PUNCT
eurjchem-2534	140	38	obesity	obesity	NOUN
eurjchem-2534	140	39	,	,	PUNCT
eurjchem-2534	140	40	and	and	CCONJ
eurjchem-2534	140	41	neurodegenerative	neurodegenerative	ADJ
eurjchem-2534	140	42	disorders	disorder	NOUN
eurjchem-2534	140	43	.	.	PUNCT
eurjchem-2534	141	1	however	however	ADV
eurjchem-2534	141	2	,	,	PUNCT
eurjchem-2534	141	3	despite	despite	SCONJ
eurjchem-2534	141	4	its	its	PRON
eurjchem-2534	141	5	promising	promising	ADJ
eurjchem-2534	141	6	therapeutic	therapeutic	ADJ
eurjchem-2534	141	7	effects	effect	NOUN
eurjchem-2534	141	8	,	,	PUNCT
eurjchem-2534	141	9	celastrol	celastrol	NOUN
eurjchem-2534	141	10	’s	’s	PART
eurjchem-2534	141	11	clinical	clinical	ADJ
eurjchem-2534	141	12	application	application	NOUN
eurjchem-2534	141	13	is	be	AUX
eurjchem-2534	141	14	hampered	hamper	VERB
eurjchem-2534	141	15	by	by	ADP
eurjchem-2534	141	16	several	several	ADJ
eurjchem-2534	141	17	notable	notable	ADJ
eurjchem-2534	141	18	side	side	NOUN
eurjchem-2534	141	19	effects	effect	NOUN
eurjchem-2534	141	20	and	and	CCONJ
eurjchem-2534	141	21	limitations	limitation	NOUN
eurjchem-2534	141	22	.	.	PUNCT
eurjchem-2534	142	1	these	these	PRON
eurjchem-2534	142	2	include	include	VERB
eurjchem-2534	142	3	its	its	PRON
eurjchem-2534	142	4	low	low	ADJ
eurjchem-2534	142	5	bioavailability	bioavailability	NOUN
eurjchem-2534	142	6	,	,	PUNCT
eurjchem-2534	142	7	which	which	PRON
eurjchem-2534	142	8	indicates	indicate	VERB
eurjchem-2534	142	9	that	that	SCONJ
eurjchem-2534	142	10	only	only	ADV
eurjchem-2534	142	11	a	a	DET
eurjchem-2534	142	12	small	small	ADJ
eurjchem-2534	142	13	fraction	fraction	NOUN
eurjchem-2534	142	14	of	of	ADP
eurjchem-2534	142	15	the	the	DET
eurjchem-2534	142	16	drug	drug	NOUN
eurjchem-2534	142	17	reaches	reach	VERB
eurjchem-2534	142	18	the	the	DET
eurjchem-2534	142	19	systemic	systemic	ADJ
eurjchem-2534	142	20	circulation	circulation	NOUN
eurjchem-2534	142	21	;	;	PUNCT
eurjchem-2534	142	22	weak	weak	ADJ
eurjchem-2534	142	23	water	water	NOUN
eurjchem-2534	142	24	solubility	solubility	NOUN
eurjchem-2534	142	25	,	,	PUNCT
eurjchem-2534	142	26	making	make	VERB
eurjchem-2534	142	27	it	it	PRON
eurjchem-2534	142	28	difficult	difficult	ADJ
eurjchem-2534	142	29	to	to	PART
eurjchem-2534	142	30	dissolve	dissolve	VERB
eurjchem-2534	142	31	in	in	ADP
eurjchem-2534	142	32	biological	biological	ADJ
eurjchem-2534	142	33	fluids	fluid	NOUN
eurjchem-2534	142	34	;	;	PUNCT
eurjchem-2534	142	35	cytotoxicity	cytotoxicity	NOUN
eurjchem-2534	142	36	,	,	PUNCT
eurjchem-2534	142	37	which	which	PRON
eurjchem-2534	142	38	could	could	AUX
eurjchem-2534	142	39	harm	harm	VERB
eurjchem-2534	142	40	healthy	healthy	ADJ
eurjchem-2534	142	41	cells	cell	NOUN
eurjchem-2534	142	42	;	;	PUNCT
eurjchem-2534	142	43	and	and	CCONJ
eurjchem-2534	142	44	hepatotoxicity	hepatotoxicity	NOUN
eurjchem-2534	142	45	,	,	PUNCT
eurjchem-2534	142	46	which	which	PRON
eurjchem-2534	142	47	poses	pose	VERB
eurjchem-2534	142	48	risks	risk	NOUN
eurjchem-2534	142	49	to	to	PART
eurjchem-2534	142	50	liver	liver	NOUN
eurjchem-2534	142	51	health	health	NOUN
eurjchem-2534	142	52	[	[	X
eurjchem-2534	142	53	46	46	NUM
eurjchem-2534	142	54	]	]	PUNCT
eurjchem-2534	142	55	.	.	PUNCT
eurjchem-2534	143	1	given	give	VERB
eurjchem-2534	143	2	these	these	DET
eurjchem-2534	143	3	limitations	limitation	NOUN
eurjchem-2534	143	4	,	,	PUNCT
eurjchem-2534	143	5	researchers	researcher	NOUN
eurjchem-2534	143	6	have	have	AUX
eurjchem-2534	143	7	been	be	AUX
eurjchem-2534	143	8	exploring	explore	VERB
eurjchem-2534	143	9	innovative	innovative	ADJ
eurjchem-2534	143	10	approaches	approach	NOUN
eurjchem-2534	143	11	to	to	PART
eurjchem-2534	143	12	improve	improve	VERB
eurjchem-2534	143	13	the	the	DET
eurjchem-2534	143	14	safety	safety	NOUN
eurjchem-2534	143	15	and	and	CCONJ
eurjchem-2534	143	16	effectiveness	effectiveness	NOUN
eurjchem-2534	143	17	of	of	ADP
eurjchem-2534	143	18	celastrol	celastrol	NOUN
eurjchem-2534	143	19	in	in	ADP
eurjchem-2534	143	20	medical	medical	ADJ
eurjchem-2534	143	21	treatment	treatment	NOUN
eurjchem-2534	143	22	.	.	PUNCT
eurjchem-2534	144	1	one	one	NUM
eurjchem-2534	144	2	of	of	ADP
eurjchem-2534	144	3	the	the	DET
eurjchem-2534	144	4	key	key	ADJ
eurjchem-2534	144	5	strategies	strategy	NOUN
eurjchem-2534	144	6	involves	involve	VERB
eurjchem-2534	144	7	the	the	DET
eurjchem-2534	144	8	development	development	NOUN
eurjchem-2534	144	9	of	of	ADP
eurjchem-2534	144	10	specialized	specialized	ADJ
eurjchem-2534	144	11	drug	drug	NOUN
eurjchem-2534	144	12	delivery	delivery	NOUN
eurjchem-2534	144	13	systems	system	NOUN
eurjchem-2534	144	14	that	that	PRON
eurjchem-2534	144	15	can	can	AUX
eurjchem-2534	144	16	improve	improve	VERB
eurjchem-2534	144	17	the	the	DET
eurjchem-2534	144	18	transportation	transportation	NOUN
eurjchem-2534	144	19	of	of	ADP
eurjchem-2534	144	20	celastrol	celastrol	NOUN
eurjchem-2534	144	21	to	to	ADP
eurjchem-2534	144	22	targeted	target	VERB
eurjchem-2534	144	23	areas	area	NOUN
eurjchem-2534	144	24	within	within	ADP
eurjchem-2534	144	25	the	the	DET
eurjchem-2534	144	26	body	body	NOUN
eurjchem-2534	144	27	.	.	PUNCT
eurjchem-2534	145	1	by	by	ADP
eurjchem-2534	145	2	ensuring	ensure	VERB
eurjchem-2534	145	3	precise	precise	ADJ
eurjchem-2534	145	4	delivery	delivery	NOUN
eurjchem-2534	145	5	,	,	PUNCT
eurjchem-2534	145	6	these	these	DET
eurjchem-2534	145	7	systems	system	NOUN
eurjchem-2534	145	8	aim	aim	VERB
eurjchem-2534	145	9	to	to	PART
eurjchem-2534	145	10	maximize	maximize	VERB
eurjchem-2534	145	11	the	the	DET
eurjchem-2534	145	12	therapeutic	therapeutic	ADJ
eurjchem-2534	145	13	benefits	benefit	NOUN
eurjchem-2534	145	14	of	of	ADP
eurjchem-2534	145	15	the	the	DET
eurjchem-2534	145	16	drug	drug	NOUN
eurjchem-2534	145	17	while	while	SCONJ
eurjchem-2534	145	18	minimizing	minimize	VERB
eurjchem-2534	145	19	its	its	PRON
eurjchem-2534	145	20	adverse	adverse	ADJ
eurjchem-2534	145	21	effects	effect	NOUN
eurjchem-2534	145	22	[	[	X
eurjchem-2534	145	23	47	47	NUM
eurjchem-2534	145	24	]	]	PUNCT
eurjchem-2534	145	25	.	.	PUNCT
eurjchem-2534	146	1	current	current	ADJ
eurjchem-2534	146	2	celastrol	celastrol	NOUN
eurjchem-2534	146	3	drug	drug	NOUN
eurjchem-2534	146	4	delivery	delivery	NOUN
eurjchem-2534	146	5	methods	method	NOUN
eurjchem-2534	146	6	can	can	AUX
eurjchem-2534	146	7	be	be	AUX
eurjchem-2534	146	8	divided	divide	VERB
eurjchem-2534	146	9	into	into	ADP
eurjchem-2534	146	10	two	two	NUM
eurjchem-2534	146	11	categories	category	NOUN
eurjchem-2534	146	12	:	:	PUNCT
eurjchem-2534	146	13	direct	direct	ADJ
eurjchem-2534	146	14	and	and	CCONJ
eurjchem-2534	146	15	indirect	indirect	ADJ
eurjchem-2534	146	16	modification	modification	NOUN
eurjchem-2534	146	17	.	.	PUNCT
eurjchem-2534	147	1	3.1	3.1	NUM
eurjchem-2534	147	2	.	.	PUNCT
eurjchem-2534	147	3	direct	direct	ADJ
eurjchem-2534	147	4	modification	modification	NOUN
eurjchem-2534	147	5	direct	direct	ADJ
eurjchem-2534	147	6	modification	modification	NOUN
eurjchem-2534	147	7	delivery	delivery	NOUN
eurjchem-2534	147	8	methods	method	NOUN
eurjchem-2534	147	9	involve	involve	VERB
eurjchem-2534	147	10	direct	direct	ADJ
eurjchem-2534	147	11	chemical	chemical	NOUN
eurjchem-2534	147	12	modification	modification	NOUN
eurjchem-2534	147	13	of	of	ADP
eurjchem-2534	147	14	the	the	DET
eurjchem-2534	147	15	celastrol	celastrol	NOUN
eurjchem-2534	147	16	molecule	molecule	NOUN
eurjchem-2534	147	17	itself	itself	PRON
eurjchem-2534	147	18	to	to	PART
eurjchem-2534	147	19	improve	improve	VERB
eurjchem-2534	147	20	its	its	PRON
eurjchem-2534	147	21	bioavailability	bioavailability	NOUN
eurjchem-2534	147	22	,	,	PUNCT
eurjchem-2534	147	23	water	water	NOUN
eurjchem-2534	147	24	solubility	solubility	NOUN
eurjchem-2534	147	25	,	,	PUNCT
eurjchem-2534	147	26	targeting	targeting	NOUN
eurjchem-2534	147	27	,	,	PUNCT
eurjchem-2534	147	28	and	and	CCONJ
eurjchem-2534	147	29	reduced	reduced	ADJ
eurjchem-2534	147	30	toxicity	toxicity	NOUN
eurjchem-2534	147	31	.	.	PUNCT
eurjchem-2534	148	1	for	for	ADP
eurjchem-2534	148	2	example	example	NOUN
eurjchem-2534	148	3	,	,	PUNCT
eurjchem-2534	148	4	by	by	ADP
eurjchem-2534	148	5	attaching	attach	VERB
eurjchem-2534	148	6	durable	durable	ADJ
eurjchem-2534	148	7	,	,	PUNCT
eurjchem-2534	148	8	highly	highly	ADV
eurjchem-2534	148	9	water	water	NOUN
eurjchem-2534	148	10	-	-	PUNCT
eurjchem-2534	148	11	soluble	soluble	ADJ
eurjchem-2534	148	12	,	,	PUNCT
eurjchem-2534	148	13	and	and	CCONJ
eurjchem-2534	148	14	biocompatible	biocompatible	ADJ
eurjchem-2534	148	15	polyethylene	polyethylene	NOUN
eurjchem-2534	148	16	glycol	glycol	NOUN
eurjchem-2534	148	17	(	(	PUNCT
eurjchem-2534	148	18	peg	peg	NOUN
eurjchem-2534	148	19	)	)	PUNCT
eurjchem-2534	148	20	to	to	PART
eurjchem-2534	148	21	celastrol	celastrol	VERB
eurjchem-2534	148	22	in	in	ADP
eurjchem-2534	148	23	an	an	DET
eurjchem-2534	148	24	appropriate	appropriate	ADJ
eurjchem-2534	148	25	manner	manner	NOUN
eurjchem-2534	148	26	,	,	PUNCT
eurjchem-2534	148	27	its	its	PRON
eurjchem-2534	148	28	water	water	NOUN
eurjchem-2534	148	29	solubility	solubility	NOUN
eurjchem-2534	148	30	can	can	AUX
eurjchem-2534	148	31	be	be	AUX
eurjchem-2534	148	32	improved	improve	VERB
eurjchem-2534	148	33	.	.	PUNCT
eurjchem-2534	149	1	when	when	SCONJ
eurjchem-2534	149	2	fatty	fatty	NOUN
eurjchem-2534	149	3	acid	acid	NOUN
eurjchem-2534	149	4	chains	chain	NOUN
eurjchem-2534	149	5	are	be	AUX
eurjchem-2534	149	6	attached	attach	VERB
eurjchem-2534	149	7	to	to	PART
eurjchem-2534	149	8	celastrol	celastrol	VERB
eurjchem-2534	149	9	,	,	PUNCT
eurjchem-2534	149	10	you	you	PRON
eurjchem-2534	149	11	can	can	AUX
eurjchem-2534	149	12	increase	increase	VERB
eurjchem-2534	149	13	its	its	PRON
eurjchem-2534	149	14	lipophilicity	lipophilicity	NOUN
eurjchem-2534	149	15	and	and	CCONJ
eurjchem-2534	149	16	membrane	membrane	NOUN
eurjchem-2534	149	17	penetration	penetration	NOUN
eurjchem-2534	149	18	capabilities	capability	NOUN
eurjchem-2534	149	19	,	,	PUNCT
eurjchem-2534	149	20	which	which	PRON
eurjchem-2534	149	21	in	in	ADP
eurjchem-2534	149	22	turn	turn	NOUN
eurjchem-2534	149	23	increases	increase	VERB
eurjchem-2534	149	24	its	its	PRON
eurjchem-2534	149	25	bioavailability	bioavailability	NOUN
eurjchem-2534	149	26	and	and	CCONJ
eurjchem-2534	149	27	therapeutic	therapeutic	ADJ
eurjchem-2534	149	28	effectiveness	effectiveness	NOUN
eurjchem-2534	149	29	.	.	PUNCT
eurjchem-2534	150	1	the	the	DET
eurjchem-2534	150	2	introduction	introduction	NOUN
eurjchem-2534	150	3	of	of	ADP
eurjchem-2534	150	4	an	an	DET
eurjchem-2534	150	5	ester	ester	NOUN
eurjchem-2534	150	6	group	group	NOUN
eurjchem-2534	150	7	into	into	ADP
eurjchem-2534	150	8	the	the	DET
eurjchem-2534	150	9	molecule	molecule	NOUN
eurjchem-2534	150	10	can	can	AUX
eurjchem-2534	150	11	protect	protect	VERB
eurjchem-2534	150	12	the	the	DET
eurjchem-2534	150	13	active	active	ADJ
eurjchem-2534	150	14	part	part	NOUN
eurjchem-2534	150	15	through	through	ADP
eurjchem-2534	150	16	an	an	DET
eurjchem-2534	150	17	esterification	esterification	NOUN
eurjchem-2534	150	18	reaction	reaction	NOUN
eurjchem-2534	150	19	.	.	PUNCT
eurjchem-2534	151	1	upon	upon	SCONJ
eurjchem-2534	151	2	entering	enter	VERB
eurjchem-2534	151	3	the	the	DET
eurjchem-2534	151	4	body	body	NOUN
eurjchem-2534	151	5	,	,	PUNCT
eurjchem-2534	151	6	the	the	DET
eurjchem-2534	151	7	enzymatic	enzymatic	ADJ
eurjchem-2534	151	8	action	action	NOUN
eurjchem-2534	151	9	cleaves	cleave	VERB
eurjchem-2534	151	10	the	the	DET
eurjchem-2534	151	11	ester	ester	NOUN
eurjchem-2534	151	12	group	group	NOUN
eurjchem-2534	151	13	,	,	PUNCT
eurjchem-2534	151	14	releasing	release	VERB
eurjchem-2534	151	15	the	the	DET
eurjchem-2534	151	16	active	active	ADJ
eurjchem-2534	151	17	celastrol	celastrol	NOUN
eurjchem-2534	151	18	.	.	PUNCT
eurjchem-2534	152	1	such	such	ADJ
eurjchem-2534	152	2	modifications	modification	NOUN
eurjchem-2534	152	3	can	can	AUX
eurjchem-2534	152	4	significantly	significantly	ADV
eurjchem-2534	152	5	improve	improve	VERB
eurjchem-2534	152	6	the	the	DET
eurjchem-2534	152	7	physicochemical	physicochemical	ADJ
eurjchem-2534	152	8	characteristics	characteristic	NOUN
eurjchem-2534	152	9	of	of	ADP
eurjchem-2534	152	10	the	the	DET
eurjchem-2534	152	11	molecules	molecule	NOUN
eurjchem-2534	152	12	,	,	PUNCT
eurjchem-2534	152	13	thereby	thereby	ADV
eurjchem-2534	152	14	addressing	address	VERB
eurjchem-2534	152	15	common	common	ADJ
eurjchem-2534	152	16	obstacles	obstacle	NOUN
eurjchem-2534	152	17	in	in	ADP
eurjchem-2534	152	18	drug	drug	NOUN
eurjchem-2534	152	19	delivery	delivery	NOUN
eurjchem-2534	152	20	,	,	PUNCT
eurjchem-2534	152	21	such	such	ADJ
eurjchem-2534	152	22	as	as	ADP
eurjchem-2534	152	23	rapid	rapid	ADJ
eurjchem-2534	152	24	degradation	degradation	NOUN
eurjchem-2534	152	25	,	,	PUNCT
eurjchem-2534	152	26	recognition	recognition	NOUN
eurjchem-2534	152	27	by	by	ADP
eurjchem-2534	152	28	the	the	DET
eurjchem-2534	152	29	immune	immune	ADJ
eurjchem-2534	152	30	system	system	NOUN
eurjchem-2534	152	31	,	,	PUNCT
eurjchem-2534	152	32	and	and	CCONJ
eurjchem-2534	152	33	limited	limited	ADJ
eurjchem-2534	152	34	cellular	cellular	ADJ
eurjchem-2534	152	35	uptake	uptake	NOUN
eurjchem-2534	152	36	.	.	PUNCT
eurjchem-2534	153	1	pengjin	pengjin	VERB
eurjchem-2534	153	2	ge	ge	PROPN
eurjchem-2534	153	3	et	et	PROPN
eurjchem-2534	153	4	al	al	PROPN
eurjchem-2534	153	5	.	.	PROPN
eurjchem-2534	153	6	have	have	AUX
eurjchem-2534	153	7	proposed	propose	VERB
eurjchem-2534	153	8	a	a	DET
eurjchem-2534	153	9	collaborative	collaborative	ADJ
eurjchem-2534	153	10	design	design	NOUN
eurjchem-2534	153	11	strategy	strategy	NOUN
eurjchem-2534	153	12	using	use	VERB
eurjchem-2534	153	13	dendrimer	dendrimer	NOUN
eurjchem-2534	153	14	polymers	polymer	NOUN
eurjchem-2534	153	15	for	for	ADP
eurjchem-2534	153	16	targeted	target	VERB
eurjchem-2534	153	17	celastrol	celastrol	NOUN
eurjchem-2534	153	18	delivery	delivery	NOUN
eurjchem-2534	153	19	in	in	ADP
eurjchem-2534	153	20	both	both	CCONJ
eurjchem-2534	153	21	in	in	ADP
eurjchem-2534	153	22	vitro	vitro	X
eurjchem-2534	153	23	sw620	sw620	ADJ
eurjchem-2534	153	24	colon	colon	NOUN
eurjchem-2534	153	25	cancer	cancer	NOUN
eurjchem-2534	153	26	cell	cell	NOUN
eurjchem-2534	153	27	models	model	NOUN
eurjchem-2534	153	28	and	and	CCONJ
eurjchem-2534	153	29	in	in	ADP
eurjchem-2534	153	30	vivo	vivo	ADJ
eurjchem-2534	153	31	sw620	sw620	ADJ
eurjchem-2534	153	32	tumor	tumor	NOUN
eurjchem-2534	153	33	-	-	PUNCT
eurjchem-2534	153	34	bearing	bear	VERB
eurjchem-2534	153	35	nude	nude	ADJ
eurjchem-2534	153	36	mice	mouse	NOUN
eurjchem-2534	153	37	,	,	PUNCT
eurjchem-2534	153	38	demonstrating	demonstrate	VERB
eurjchem-2534	153	39	good	good	ADJ
eurjchem-2534	153	40	specificity	specificity	NOUN
eurjchem-2534	153	41	,	,	PUNCT
eurjchem-2534	153	42	efficiency	efficiency	NOUN
eurjchem-2534	153	43	and	and	CCONJ
eurjchem-2534	153	44	biosafety	biosafety	NOUN
eurjchem-2534	153	45	.	.	PUNCT
eurjchem-2534	154	1	successful	successful	ADJ
eurjchem-2534	154	2	design	design	NOUN
eurjchem-2534	154	3	can	can	AUX
eurjchem-2534	154	4	also	also	ADV
eurjchem-2534	154	5	be	be	AUX
eurjchem-2534	154	6	applied	apply	VERB
eurjchem-2534	154	7	to	to	ADP
eurjchem-2534	154	8	the	the	DET
eurjchem-2534	154	9	treatment	treatment	NOUN
eurjchem-2534	154	10	of	of	ADP
eurjchem-2534	154	11	liver	liver	NOUN
eurjchem-2534	154	12	cancer	cancer	NOUN
eurjchem-2534	154	13	,	,	PUNCT
eurjchem-2534	154	14	not	not	PART
eurjchem-2534	154	15	limited	limit	VERB
eurjchem-2534	154	16	to	to	ADP
eurjchem-2534	154	17	colon	colon	NOUN
eurjchem-2534	154	18	and	and	CCONJ
eurjchem-2534	154	19	liver	liver	NOUN
eurjchem-2534	154	20	cancer	cancer	NOUN
eurjchem-2534	154	21	[	[	X
eurjchem-2534	154	22	48	48	NUM
eurjchem-2534	154	23	]	]	PUNCT
eurjchem-2534	154	24	.	.	PUNCT
eurjchem-2534	155	1	yanan	yanan	PROPN
eurjchem-2534	155	2	tan	tan	PROPN
eurjchem-2534	155	3	et	et	PROPN
eurjchem-2534	155	4	al	al	PROPN
eurjchem-2534	155	5	.	.	PROPN
eurjchem-2534	155	6	utilized	utilize	VERB
eurjchem-2534	155	7	lipophilic	lipophilic	ADJ
eurjchem-2534	155	8	cationic	cationic	ADJ
eurjchem-2534	155	9	ctpp	ctpp	NOUN
eurjchem-2534	155	10	(	(	PUNCT
eurjchem-2534	155	11	a	a	DET
eurjchem-2534	155	12	type	type	NOUN
eurjchem-2534	155	13	of	of	ADP
eurjchem-2534	155	14	tpp	tpp	PROPN
eurjchem-2534	155	15	cation	cation	NOUN
eurjchem-2534	155	16	)	)	PUNCT
eurjchem-2534	155	17	to	to	PART
eurjchem-2534	155	18	modify	modify	VERB
eurjchem-2534	155	19	the	the	DET
eurjchem-2534	155	20	liposome	liposome	NOUN
eurjchem-2534	155	21	carrier	carrier	NOUN
eurjchem-2534	155	22	csosa	csosa	PROPN
eurjchem-2534	155	23	,	,	PUNCT
eurjchem-2534	155	24	preparing	prepare	VERB
eurjchem-2534	155	25	targeted	target	VERB
eurjchem-2534	155	26	mitochondrial	mitochondrial	ADJ
eurjchem-2534	155	27	nanoparticles	nanoparticle	NOUN
eurjchem-2534	155	28	loaded	load	VERB
eurjchem-2534	155	29	with	with	ADP
eurjchem-2534	155	30	celastrol	celastrol	NOUN
eurjchem-2534	155	31	,	,	PUNCT
eurjchem-2534	155	32	resulting	result	VERB
eurjchem-2534	155	33	in	in	ADP
eurjchem-2534	155	34	ctpp	ctpp	NOUN
eurjchem-2534	155	35	-	-	PUNCT
eurjchem-2534	155	36	csosa	csosa	NOUN
eurjchem-2534	155	37	/	/	SYM
eurjchem-2534	155	38	celastrol	celastrol	NOUN
eurjchem-2534	155	39	micelles	micelle	NOUN
eurjchem-2534	155	40	.	.	PUNCT
eurjchem-2534	156	1	in	in	ADP
eurjchem-2534	156	2	vivo	vivo	ADJ
eurjchem-2534	156	3	experiments	experiment	NOUN
eurjchem-2534	156	4	demonstrated	demonstrate	VERB
eurjchem-2534	156	5	that	that	SCONJ
eurjchem-2534	156	6	micelles	micelle	NOUN
eurjchem-2534	156	7	can	can	AUX
eurjchem-2534	156	8	facilitate	facilitate	VERB
eurjchem-2534	156	9	rapid	rapid	ADJ
eurjchem-2534	156	10	drug	drug	NOUN
eurjchem-2534	156	11	release	release	NOUN
eurjchem-2534	156	12	into	into	ADP
eurjchem-2534	156	13	the	the	DET
eurjchem-2534	156	14	mitochondria	mitochondria	NOUN
eurjchem-2534	156	15	,	,	PUNCT
eurjchem-2534	156	16	reducing	reduce	VERB
eurjchem-2534	156	17	drug	drug	NOUN
eurjchem-2534	156	18	leakage	leakage	NOUN
eurjchem-2534	156	19	into	into	ADP
eurjchem-2534	156	20	the	the	DET
eurjchem-2534	156	21	cytoplasm	cytoplasm	NOUN
eurjchem-2534	156	22	and	and	CCONJ
eurjchem-2534	156	23	lysosome	lysosome	ADJ
eurjchem-2534	156	24	,	,	PUNCT
eurjchem-2534	156	25	and	and	CCONJ
eurjchem-2534	156	26	significantly	significantly	ADV
eurjchem-2534	156	27	increasing	increase	VERB
eurjchem-2534	156	28	the	the	DET
eurjchem-2534	156	29	tumor	tumor	NOUN
eurjchem-2534	156	30	inhibition	inhibition	NOUN
eurjchem-2534	156	31	rate	rate	NOUN
eurjchem-2534	156	32	of	of	ADP
eurjchem-2534	156	33	celastrol	celastrol	NOUN
eurjchem-2534	156	34	from	from	ADP
eurjchem-2534	156	35	54.89	54.89	NUM
eurjchem-2534	156	36	to	to	ADP
eurjchem-2534	156	37	80.17	80.17	NUM
eurjchem-2534	156	38	%	%	NOUN
eurjchem-2534	157	1	[	[	X
eurjchem-2534	157	2	49	49	NUM
eurjchem-2534	157	3	]	]	PUNCT
eurjchem-2534	157	4	.	.	PUNCT
eurjchem-2534	158	1	3.2	3.2	NUM
eurjchem-2534	158	2	.	.	PUNCT
eurjchem-2534	159	1	indirect	indirect	ADJ
eurjchem-2534	159	2	modification	modification	NOUN
eurjchem-2534	159	3	indirect	indirect	ADJ
eurjchem-2534	159	4	modification	modification	NOUN
eurjchem-2534	159	5	drug	drug	NOUN
eurjchem-2534	159	6	delivery	delivery	NOUN
eurjchem-2534	159	7	systems	system	NOUN
eurjchem-2534	159	8	work	work	VERB
eurjchem-2534	159	9	by	by	ADP
eurjchem-2534	159	10	encapsulating	encapsulate	VERB
eurjchem-2534	159	11	or	or	CCONJ
eurjchem-2534	159	12	wrapping	wrap	VERB
eurjchem-2534	159	13	the	the	DET
eurjchem-2534	159	14	celastrol	celastrol	NOUN
eurjchem-2534	159	15	molecule	molecule	NOUN
eurjchem-2534	159	16	rather	rather	ADV
eurjchem-2534	159	17	than	than	ADP
eurjchem-2534	159	18	directly	directly	ADV
eurjchem-2534	159	19	altering	alter	VERB
eurjchem-2534	159	20	its	its	PRON
eurjchem-2534	159	21	chemical	chemical	NOUN
eurjchem-2534	159	22	structure	structure	NOUN
eurjchem-2534	159	23	.	.	PUNCT
eurjchem-2534	160	1	in	in	ADP
eurjchem-2534	160	2	this	this	DET
eurjchem-2534	160	3	system	system	NOUN
eurjchem-2534	160	4	,	,	PUNCT
eurjchem-2534	160	5	the	the	DET
eurjchem-2534	160	6	therapeutic	therapeutic	ADJ
eurjchem-2534	160	7	agent	agent	NOUN
eurjchem-2534	160	8	is	be	AUX
eurjchem-2534	160	9	encapsulated	encapsulate	VERB
eurjchem-2534	160	10	or	or	CCONJ
eurjchem-2534	160	11	embedded	embed	VERB
eurjchem-2534	160	12	within	within	ADP
eurjchem-2534	160	13	the	the	DET
eurjchem-2534	160	14	carrier	carrier	NOUN
eurjchem-2534	160	15	structure	structure	NOUN
eurjchem-2534	160	16	,	,	PUNCT
eurjchem-2534	160	17	thereby	thereby	ADV
eurjchem-2534	160	18	preventing	prevent	VERB
eurjchem-2534	160	19	degradation	degradation	NOUN
eurjchem-2534	160	20	,	,	PUNCT
eurjchem-2534	160	21	improving	improve	VERB
eurjchem-2534	160	22	solubility	solubility	NOUN
eurjchem-2534	160	23	,	,	PUNCT
eurjchem-2534	160	24	controlling	control	VERB
eurjchem-2534	160	25	release	release	NOUN
eurjchem-2534	160	26	,	,	PUNCT
eurjchem-2534	160	27	and	and	CCONJ
eurjchem-2534	160	28	enhancing	enhance	VERB
eurjchem-2534	160	29	bioavailability	bioavailability	NOUN
eurjchem-2534	160	30	.	.	PUNCT
eurjchem-2534	161	1	dendritic	dendritic	ADJ
eurjchem-2534	161	2	polymers	polymer	NOUN
eurjchem-2534	161	3	are	be	AUX
eurjchem-2534	161	4	highly	highly	ADV
eurjchem-2534	161	5	defined	define	VERB
eurjchem-2534	161	6	artificial	artificial	ADJ
eurjchem-2534	161	7	polymer	polymer	NOUN
eurjchem-2534	161	8	macromolecules	macromolecule	NOUN
eurjchem-2534	161	9	characterized	characterize	VERB
eurjchem-2534	161	10	by	by	ADP
eurjchem-2534	161	11	a	a	DET
eurjchem-2534	161	12	combination	combination	NOUN
eurjchem-2534	161	13	of	of	ADP
eurjchem-2534	161	14	numerous	numerous	ADJ
eurjchem-2534	161	15	functional	functional	ADJ
eurjchem-2534	161	16	groups	group	NOUN
eurjchem-2534	161	17	and	and	CCONJ
eurjchem-2534	161	18	a	a	DET
eurjchem-2534	161	19	compact	compact	ADJ
eurjchem-2534	161	20	molecular	molecular	ADJ
eurjchem-2534	161	21	structure	structure	NOUN
eurjchem-2534	161	22	.	.	PUNCT
eurjchem-2534	162	1	b.	b.	PROPN
eurjchem-2534	162	2	niu	niu	PROPN
eurjchem-2534	162	3	and	and	CCONJ
eurjchem-2534	162	4	colleagues	colleague	NOUN
eurjchem-2534	162	5	conjugated	conjugate	VERB
eurjchem-2534	162	6	1	1	NUM
eurjchem-2534	162	7	with	with	ADP
eurjchem-2534	162	8	pegylated	pegylated	ADJ
eurjchem-2534	162	9	epcam	epcam	NOUN
eurjchem-2534	162	10	aptamer	aptamer	NOUN
eurjchem-2534	162	11	or	or	CCONJ
eurjchem-2534	162	12	antibody	antibody	VERB
eurjchem-2534	162	13	dendritic	dendritic	ADJ
eurjchem-2534	162	14	macromolecules	macromolecule	NOUN
eurjchem-2534	162	15	,	,	PUNCT
eurjchem-2534	162	16	obtaining	obtain	VERB
eurjchem-2534	162	17	two	two	NUM
eurjchem-2534	162	18	types	type	NOUN
eurjchem-2534	162	19	of	of	ADP
eurjchem-2534	162	20	nanoconjugates	nanoconjugate	NOUN
eurjchem-2534	162	21	[	[	X
eurjchem-2534	162	22	50	50	NUM
eurjchem-2534	162	23	]	]	PUNCT
eurjchem-2534	162	24	.	.	PUNCT
eurjchem-2534	163	1	the	the	DET
eurjchem-2534	163	2	results	result	NOUN
eurjchem-2534	163	3	showed	show	VERB
eurjchem-2534	163	4	that	that	SCONJ
eurjchem-2534	163	5	,	,	PUNCT
eurjchem-2534	163	6	compared	compare	VERB
eurjchem-2534	163	7	to	to	ADP
eurjchem-2534	163	8	the	the	DET
eurjchem-2534	163	9	antibody	antibody	NOUN
eurjchem-2534	163	10	counterpart	counterpart	NOUN
eurjchem-2534	163	11	,	,	PUNCT
eurjchem-2534	163	12	the	the	DET
eurjchem-2534	163	13	pegylated	pegylated	ADJ
eurjchem-2534	163	14	aptamer	aptamer	NOUN
eurjchem-2534	163	15	nanoconjugate	nanoconjugate	NOUN
eurjchem-2534	163	16	demonstrated	demonstrate	VERB
eurjchem-2534	163	17	enhanced	enhanced	ADJ
eurjchem-2534	163	18	accumulation	accumulation	NOUN
eurjchem-2534	163	19	and	and	CCONJ
eurjchem-2534	163	20	specific	specific	ADJ
eurjchem-2534	163	21	retention	retention	NOUN
eurjchem-2534	163	22	at	at	ADP
eurjchem-2534	163	23	the	the	DET
eurjchem-2534	163	24	tumor	tumor	NOUN
eurjchem-2534	163	25	site	site	NOUN
eurjchem-2534	163	26	,	,	PUNCT
eurjchem-2534	163	27	as	as	ADV
eurjchem-2534	163	28	well	well	ADV
eurjchem-2534	163	29	as	as	ADP
eurjchem-2534	163	30	stronger	strong	ADJ
eurjchem-2534	163	31	intratumoral	intratumoral	ADJ
eurjchem-2534	163	32	penetration	penetration	NOUN
eurjchem-2534	163	33	ability	ability	NOUN
eurjchem-2534	163	34	by	by	ADP
eurjchem-2534	163	35	reducing	reduce	VERB
eurjchem-2534	163	36	the	the	DET
eurjchem-2534	163	37	macrophage	macrophage	ADJ
eurjchem-2534	163	38	reservoir	reservoir	NOUN
eurjchem-2534	163	39	effect	effect	NOUN
eurjchem-2534	163	40	in	in	ADP
eurjchem-2534	163	41	solid	solid	ADJ
eurjchem-2534	163	42	tumors	tumor	NOUN
eurjchem-2534	163	43	.	.	PUNCT
eurjchem-2534	164	1	when	when	SCONJ
eurjchem-2534	164	2	1	1	NUM
eurjchem-2534	164	3	was	be	AUX
eurjchem-2534	164	4	delivered	deliver	VERB
eurjchem-2534	164	5	to	to	ADP
eurjchem-2534	164	6	a	a	DET
eurjchem-2534	164	7	mouse	mouse	NOUN
eurjchem-2534	164	8	model	model	NOUN
eurjchem-2534	164	9	of	of	ADP
eurjchem-2534	164	10	colorectal	colorectal	ADJ
eurjchem-2534	164	11	heterograft	heterograft	NOUN
eurjchem-2534	164	12	tumor	tumor	NOUN
eurjchem-2534	164	13	through	through	ADP
eurjchem-2534	164	14	pegylated	pegylate	VERB
eurjchem-2534	164	15	aptamer	aptamer	NOUN
eurjchem-2534	164	16	dendritic	dendritic	ADJ
eurjchem-2534	164	17	polymers	polymer	NOUN
eurjchem-2534	164	18	,	,	PUNCT
eurjchem-2534	164	19	the	the	DET
eurjchem-2534	164	20	therapeutic	therapeutic	ADJ
eurjchem-2534	164	21	efficacy	efficacy	NOUN
eurjchem-2534	164	22	increased	increase	VERB
eurjchem-2534	164	23	by	by	ADP
eurjchem-2534	164	24	20	20	NUM
eurjchem-2534	164	25	%	%	NOUN
eurjchem-2534	164	26	compared	compare	VERB
eurjchem-2534	164	27	200	200	NUM
eurjchem-2534	164	28	ren	ren	NOUN
eurjchem-2534	164	29	and	and	CCONJ
eurjchem-2534	164	30	coghi	coghi	PROPN
eurjchem-2534	164	31	/	/	SYM
eurjchem-2534	164	32	european	european	PROPN
eurjchem-2534	164	33	journal	journal	PROPN
eurjchem-2534	164	34	of	of	ADP
eurjchem-2534	164	35	chemistry	chemistry	NOUN
eurjchem-2534	164	36	15	15	NUM
eurjchem-2534	164	37	(	(	PUNCT
eurjchem-2534	164	38	2	2	NUM
eurjchem-2534	164	39	)	)	PUNCT
eurjchem-2534	164	40	(	(	PUNCT
eurjchem-2534	164	41	2024	2024	NUM
eurjchem-2534	164	42	)	)	PUNCT
eurjchem-2534	164	43	194	194	NUM
eurjchem-2534	164	44	-	-	SYM
eurjchem-2534	164	45	204	204	NUM
eurjchem-2534	164	46	2024	2024	NUM
eurjchem-2534	164	47	–	–	PUNCT
eurjchem-2534	164	48	european	european	ADJ
eurjchem-2534	164	49	journal	journal	NOUN
eurjchem-2534	164	50	of	of	ADP
eurjchem-2534	164	51	chemistry	chemistry	NOUN
eurjchem-2534	164	52	–	–	PUNCT
eurjchem-2534	164	53	cc	cc	NOUN
eurjchem-2534	164	54	by	by	ADP
eurjchem-2534	164	55	nc	nc	PROPN
eurjchem-2534	164	56	–	–	PUNCT
eurjchem-2534	164	57	doi	doi	PROPN
eurjchem-2534	164	58	:	:	PUNCT
eurjchem-2534	164	59	10.5155	10.5155	NUM
eurjchem-2534	164	60	/	/	SYM
eurjchem-2534	164	61	eurjchem.15.2.194	eurjchem.15.2.194	NOUN
eurjchem-2534	164	62	-	-	SYM
eurjchem-2534	164	63	204.2534	204.2534	NUM
eurjchem-2534	164	64	o	o	NOUN
eurjchem-2534	164	65	ho	ho	ADJ
eurjchem-2534	164	66	h	h	NOUN
eurjchem-2534	165	1	o	o	NOUN
eurjchem-2534	165	2	o	o	NOUN
eurjchem-2534	165	3	n	n	CCONJ
eurjchem-2534	165	4	n	n	CCONJ
eurjchem-2534	165	5	n	n	ADV
eurjchem-2534	165	6	o	o	NOUN
eurjchem-2534	165	7	ho	ho	INTJ
eurjchem-2534	166	1	h	h	NOUN
eurjchem-2534	166	2	o	o	NOUN
eurjchem-2534	166	3	o	o	NOUN
eurjchem-2534	166	4	n	n	CCONJ
eurjchem-2534	166	5	n	n	CCONJ
eurjchem-2534	166	6	n	n	PROPN
eurjchem-2534	166	7	(	(	PUNCT
eurjchem-2534	166	8	b	b	NOUN
eurjchem-2534	166	9	)	)	PUNCT
eurjchem-2534	166	10	29	29	NUM
eurjchem-2534	166	11	30	30	NUM
eurjchem-2534	166	12	31	31	NUM
eurjchem-2534	166	13	o	o	NOUN
eurjchem-2534	166	14	ho	ho	PROPN
eurjchem-2534	167	1	h	h	NOUN
eurjchem-2534	167	2	o	o	NOUN
eurjchem-2534	167	3	o	o	NOUN
eurjchem-2534	167	4	n	n	CCONJ
eurjchem-2534	167	5	n	n	CCONJ
eurjchem-2534	167	6	n	n	ADV
eurjchem-2534	167	7	cl	cl	NOUN
eurjchem-2534	167	8	f	f	NOUN
eurjchem-2534	167	9	1	1	NUM
eurjchem-2534	167	10	4	4	NUM
eurjchem-2534	167	11	6	6	NUM
eurjchem-2534	167	12	8	8	NUM
eurjchem-2534	167	13	20	20	NUM
eurjchem-2534	167	14	2	2	NUM
eurjchem-2534	167	15	3	3	NUM
eurjchem-2534	167	16	29	29	NUM
eurjchem-2534	167	17	1	1	NUM
eurjchem-2534	167	18	4	4	NUM
eurjchem-2534	167	19	6	6	NUM
eurjchem-2534	167	20	8	8	NUM
eurjchem-2534	167	21	20	20	NUM
eurjchem-2534	167	22	2	2	NUM
eurjchem-2534	167	23	3	3	NUM
eurjchem-2534	167	24	29	29	NUM
eurjchem-2534	167	25	1	1	NUM
eurjchem-2534	167	26	4	4	NUM
eurjchem-2534	167	27	6	6	NUM
eurjchem-2534	167	28	8	8	NUM
eurjchem-2534	167	29	20	20	NUM
eurjchem-2534	167	30	2	2	NUM
eurjchem-2534	167	31	3	3	NUM
eurjchem-2534	167	32	29	29	NUM
eurjchem-2534	167	33	o	o	NOUN
eurjchem-2534	167	34	ho	ho	PROPN
eurjchem-2534	167	35	h1	h1	PROPN
eurjchem-2534	167	36	4	4	NUM
eurjchem-2534	167	37	6	6	NUM
eurjchem-2534	167	38	8	8	NUM
eurjchem-2534	167	39	20	20	NUM
eurjchem-2534	167	40	2	2	NUM
eurjchem-2534	167	41	3	3	NUM
eurjchem-2534	167	42	29	29	NUM
eurjchem-2534	167	43	o	o	NOUN
eurjchem-2534	167	44	o	o	NOUN
eurjchem-2534	167	45	h	h	NOUN
eurjchem-2534	167	46	n	n	ADP
eurjchem-2534	167	47	o	o	NOUN
eurjchem-2534	167	48	n	n	CCONJ
eurjchem-2534	167	49	n	n	CCONJ
eurjchem-2534	167	50	n	n	NOUN
eurjchem-2534	167	51	r	r	NOUN
eurjchem-2534	167	52	o	o	NOUN
eurjchem-2534	168	1	o	o	NOUN
eurjchem-2534	168	2	h	h	NOUN
eurjchem-2534	168	3	o	o	X
eurjchem-2534	168	4	o	o	NOUN
eurjchem-2534	168	5	on	on	ADP
eurjchem-2534	168	6	n	n	CCONJ
eurjchem-2534	169	1	n	n	ADV
eurjchem-2534	169	2	r	r	NOUN
eurjchem-2534	169	3	'	'	PUNCT
eurjchem-2534	169	4	r	r	NOUN
eurjchem-2534	169	5	'	'	PUNCT
eurjchem-2534	169	6	=	=	NOUN
eurjchem-2534	169	7	x	x	SYM
eurjchem-2534	169	8	x=	x=	PROPN
eurjchem-2534	170	1	f	f	X
eurjchem-2534	170	2	,	,	PUNCT
eurjchem-2534	170	3	br	br	PROPN
eurjchem-2534	170	4	,	,	PUNCT
eurjchem-2534	170	5	cl	cl	NOUN
eurjchem-2534	170	6	,	,	PUNCT
eurjchem-2534	170	7	me	i	PRON
eurjchem-2534	170	8	,	,	PUNCT
eurjchem-2534	170	9	och3	och3	ADJ
eurjchem-2534	170	10	,	,	PUNCT
eurjchem-2534	170	11	cn	cn	NOUN
eurjchem-2534	170	12	r	r	NOUN
eurjchem-2534	170	13	'	'	PUNCT
eurjchem-2534	170	14	=	=	NOUN
eurjchem-2534	170	15	,	,	PUNCT
eurjchem-2534	170	16	,	,	PUNCT
eurjchem-2534	170	17	,	,	PUNCT
eurjchem-2534	170	18	(	(	PUNCT
eurjchem-2534	170	19	a	a	X
eurjchem-2534	170	20	)	)	PUNCT
eurjchem-2534	170	21	26	26	NUM
eurjchem-2534	170	22	28	28	NUM
eurjchem-2534	170	23	1	1	NUM
eurjchem-2534	170	24	4	4	NUM
eurjchem-2534	170	25	6	6	NUM
eurjchem-2534	170	26	8	8	NUM
eurjchem-2534	170	27	20	20	NUM
eurjchem-2534	170	28	2	2	NUM
eurjchem-2534	170	29	3	3	NUM
eurjchem-2534	170	30	29	29	NUM
eurjchem-2534	170	31	(	(	PUNCT
eurjchem-2534	170	32	c	c	NOUN
eurjchem-2534	170	33	)	)	PUNCT
eurjchem-2534	170	34	o	o	NOUN
eurjchem-2534	170	35	ho	ho	PROPN
eurjchem-2534	170	36	h1	h1	PROPN
eurjchem-2534	170	37	4	4	NUM
eurjchem-2534	170	38	6	6	NUM
eurjchem-2534	170	39	8	8	NUM
eurjchem-2534	170	40	20	20	NUM
eurjchem-2534	170	41	2	2	NUM
eurjchem-2534	170	42	3	3	NUM
eurjchem-2534	170	43	29	29	NUM
eurjchem-2534	171	1	o	o	NOUN
eurjchem-2534	171	2	o	o	NOUN
eurjchem-2534	171	3	h	h	NOUN
eurjchem-2534	171	4	n	n	ADP
eurjchem-2534	171	5	o	o	NOUN
eurjchem-2534	171	6	n	n	CCONJ
eurjchem-2534	171	7	n	n	CCONJ
eurjchem-2534	171	8	n	n	NOUN
eurjchem-2534	171	9	r	r	NOUN
eurjchem-2534	171	10	32	32	NUM
eurjchem-2534	171	11	r=	r=	ADJ
eurjchem-2534	171	12	h	h	NOUN
eurjchem-2534	171	13	,	,	PUNCT
eurjchem-2534	171	14	4	4	NUM
eurjchem-2534	171	15	-	-	PUNCT
eurjchem-2534	171	16	ch3	ch3	ADJ
eurjchem-2534	171	17	,	,	PUNCT
eurjchem-2534	171	18	4	4	NUM
eurjchem-2534	171	19	-	-	PUNCT
eurjchem-2534	171	20	och3	och3	ADJ
eurjchem-2534	171	21	,	,	PUNCT
eurjchem-2534	171	22	4	4	NUM
eurjchem-2534	171	23	-	-	PUNCT
eurjchem-2534	171	24	cl	cl	NOUN
eurjchem-2534	171	25	,	,	PUNCT
eurjchem-2534	171	26	3,4	3,4	NUM
eurjchem-2534	171	27	-	-	PUNCT
eurjchem-2534	171	28	cl2	cl2	NOUN
eurjchem-2534	171	29	r=	r=	ADJ
eurjchem-2534	171	30	x	x	SYM
eurjchem-2534	171	31	x=	x=	X
eurjchem-2534	172	1	c(ch3)3	c(ch3)3	ADJ
eurjchem-2534	172	2	,	,	PUNCT
eurjchem-2534	172	3	och3	och3	ADJ
eurjchem-2534	172	4	,	,	PUNCT
eurjchem-2534	172	5	br	br	PROPN
eurjchem-2534	172	6	,	,	PUNCT
eurjchem-2534	172	7	cn	cn	PROPN
eurjchem-2534	172	8	,	,	PUNCT
eurjchem-2534	172	9	f	f	NOUN
eurjchem-2534	172	10	,	,	PUNCT
eurjchem-2534	172	11	cl	cl	INTJ
eurjchem-2534	172	12	,	,	PUNCT
eurjchem-2534	172	13	,	,	PUNCT
eurjchem-2534	172	14	o	o	NOUN
eurjchem-2534	172	15	ho	ho	PROPN
eurjchem-2534	172	16	h	h	PROPN
eurjchem-2534	172	17	n	n	NOUN
eurjchem-2534	172	18	h	h	NOUN
eurjchem-2534	172	19	o	o	NOUN
eurjchem-2534	172	20	n	n	CCONJ
eurjchem-2534	172	21	n	n	CCONJ
eurjchem-2534	172	22	n	n	NOUN
eurjchem-2534	172	23	r	r	NOUN
eurjchem-2534	172	24	27	27	NUM
eurjchem-2534	172	25	1	1	NUM
eurjchem-2534	172	26	4	4	NUM
eurjchem-2534	172	27	6	6	NUM
eurjchem-2534	172	28	8	8	NUM
eurjchem-2534	172	29	20	20	NUM
eurjchem-2534	172	30	2	2	NUM
eurjchem-2534	172	31	3	3	NUM
eurjchem-2534	172	32	29	29	NUM
eurjchem-2534	172	33	figure	figure	NOUN
eurjchem-2534	172	34	7	7	NUM
eurjchem-2534	172	35	.	.	PUNCT
eurjchem-2534	173	1	(	(	PUNCT
eurjchem-2534	173	2	a	a	X
eurjchem-2534	173	3	)	)	PUNCT
eurjchem-2534	173	4	1,2,3	1,2,3	NUM
eurjchem-2534	173	5	-	-	ADJ
eurjchem-2534	173	6	triazole	triazole	ADJ
eurjchem-2534	173	7	derivatives	derivative	NOUN
eurjchem-2534	173	8	26	26	NUM
eurjchem-2534	173	9	–	–	PUNCT
eurjchem-2534	173	10	28	28	NUM
eurjchem-2534	173	11	obtained	obtain	VERB
eurjchem-2534	173	12	by	by	ADP
eurjchem-2534	173	13	click	click	VERB
eurjchem-2534	173	14	chemistry	chemistry	NOUN
eurjchem-2534	173	15	[	[	X
eurjchem-2534	173	16	44	44	NUM
eurjchem-2534	173	17	]	]	PUNCT
eurjchem-2534	173	18	and	and	CCONJ
eurjchem-2534	173	19	(	(	PUNCT
eurjchem-2534	173	20	b	b	NOUN
eurjchem-2534	173	21	,	,	PUNCT
eurjchem-2534	173	22	c	c	NOUN
eurjchem-2534	173	23	)	)	PUNCT
eurjchem-2534	173	24	some	some	DET
eurjchem-2534	173	25	representative	representative	NOUN
eurjchem-2534	173	26	in	in	ADP
eurjchem-2534	173	27	the	the	DET
eurjchem-2534	173	28	literature	literature	NOUN
eurjchem-2534	173	29	of	of	ADP
eurjchem-2534	173	30	celastrol	celastrol	NOUN
eurjchem-2534	173	31	triazole	triazole	NOUN
eurjchem-2534	173	32	29–32	29–32	NUM
eurjchem-2534	174	1	[	[	X
eurjchem-2534	174	2	36,43,45	36,43,45	NUM
eurjchem-2534	174	3	]	]	PUNCT
eurjchem-2534	174	4	.	.	PUNCT
eurjchem-2534	175	1	ren	ren	PROPN
eurjchem-2534	175	2	and	and	CCONJ
eurjchem-2534	175	3	coghi	coghi	PROPN
eurjchem-2534	175	4	/	/	SYM
eurjchem-2534	175	5	european	european	PROPN
eurjchem-2534	175	6	journal	journal	PROPN
eurjchem-2534	175	7	of	of	ADP
eurjchem-2534	175	8	chemistry	chemistry	NOUN
eurjchem-2534	175	9	15	15	NUM
eurjchem-2534	175	10	(	(	PUNCT
eurjchem-2534	175	11	2	2	NUM
eurjchem-2534	175	12	)	)	PUNCT
eurjchem-2534	175	13	(	(	PUNCT
eurjchem-2534	175	14	2024	2024	NUM
eurjchem-2534	175	15	)	)	PUNCT
eurjchem-2534	175	16	194	194	NUM
eurjchem-2534	175	17	-	-	SYM
eurjchem-2534	175	18	204	204	NUM
eurjchem-2534	175	19	201	201	NUM
eurjchem-2534	175	20	2024	2024	NUM
eurjchem-2534	175	21	–	–	PUNCT
eurjchem-2534	175	22	european	european	ADJ
eurjchem-2534	175	23	journal	journal	NOUN
eurjchem-2534	175	24	of	of	ADP
eurjchem-2534	175	25	chemistry	chemistry	NOUN
eurjchem-2534	175	26	–	–	PUNCT
eurjchem-2534	175	27	cc	cc	NOUN
eurjchem-2534	175	28	by	by	ADP
eurjchem-2534	175	29	nc	nc	PROPN
eurjchem-2534	175	30	–	–	PUNCT
eurjchem-2534	175	31	doi	doi	PROPN
eurjchem-2534	175	32	:	:	PUNCT
eurjchem-2534	175	33	10.5155	10.5155	NUM
eurjchem-2534	175	34	/	/	SYM
eurjchem-2534	175	35	eurjchem.15.2.194	eurjchem.15.2.194	NUM
eurjchem-2534	175	36	-	-	PUNCT
eurjchem-2534	175	37	204.2534	204.2534	NUM
eurjchem-2534	175	38	table	table	NOUN
eurjchem-2534	175	39	1	1	NUM
eurjchem-2534	175	40	.	.	PUNCT
eurjchem-2534	176	1	different	different	ADJ
eurjchem-2534	176	2	drug	drug	NOUN
eurjchem-2534	176	3	delivery	delivery	NOUN
eurjchem-2534	176	4	for	for	ADP
eurjchem-2534	176	5	celastrol	celastrol	NOUN
eurjchem-2534	176	6	.	.	PUNCT
eurjchem-2534	177	1	drug	drug	NOUN
eurjchem-2534	177	2	delivery	delivery	NOUN
eurjchem-2534	177	3	type	type	NOUN
eurjchem-2534	177	4	advantages	advantage	NOUN
eurjchem-2534	177	5	disadvantages	disadvantage	VERB
eurjchem-2534	177	6	direct	direct	ADJ
eurjchem-2534	177	7	glucolipid	glucolipid	NOUN
eurjchem-2534	177	8	[	[	X
eurjchem-2534	177	9	56	56	NUM
eurjchem-2534	177	10	]	]	PUNCT
eurjchem-2534	177	11	improved	improved	ADJ
eurjchem-2534	177	12	water	water	NOUN
eurjchem-2534	177	13	solubility	solubility	NOUN
eurjchem-2534	177	14	:	:	PUNCT
eurjchem-2534	177	15	glucolipids	glucolipid	NOUN
eurjchem-2534	177	16	combine	combine	VERB
eurjchem-2534	177	17	sugar	sugar	NOUN
eurjchem-2534	177	18	and	and	CCONJ
eurjchem-2534	177	19	lipid	lipid	NOUN
eurjchem-2534	177	20	groups	group	NOUN
eurjchem-2534	177	21	,	,	PUNCT
eurjchem-2534	177	22	enhancing	enhance	VERB
eurjchem-2534	177	23	the	the	DET
eurjchem-2534	177	24	solubility	solubility	NOUN
eurjchem-2534	177	25	of	of	ADP
eurjchem-2534	177	26	lipophilic	lipophilic	ADJ
eurjchem-2534	177	27	drugs	drug	NOUN
eurjchem-2534	177	28	.	.	PUNCT
eurjchem-2534	178	1	biocompatibility	biocompatibility	NOUN
eurjchem-2534	178	2	:	:	PUNCT
eurjchem-2534	178	3	typically	typically	ADV
eurjchem-2534	178	4	derived	derive	VERB
eurjchem-2534	178	5	from	from	ADP
eurjchem-2534	178	6	natural	natural	ADJ
eurjchem-2534	178	7	sources	source	NOUN
eurjchem-2534	178	8	,	,	PUNCT
eurjchem-2534	178	9	glucolipids	glucolipid	NOUN
eurjchem-2534	178	10	are	be	AUX
eurjchem-2534	178	11	generally	generally	ADV
eurjchem-2534	178	12	biocompatible	biocompatible	ADJ
eurjchem-2534	178	13	.	.	PUNCT
eurjchem-2534	179	1	targeted	target	VERB
eurjchem-2534	179	2	delivery	delivery	NOUN
eurjchem-2534	179	3	:	:	PUNCT
eurjchem-2534	179	4	their	their	PRON
eurjchem-2534	179	5	amphiphilic	amphiphilic	ADJ
eurjchem-2534	179	6	nature	nature	NOUN
eurjchem-2534	179	7	allows	allow	VERB
eurjchem-2534	179	8	for	for	ADP
eurjchem-2534	179	9	better	well	ADJ
eurjchem-2534	179	10	cellular	cellular	ADJ
eurjchem-2534	179	11	uptake	uptake	NOUN
eurjchem-2534	179	12	and	and	CCONJ
eurjchem-2534	179	13	potentially	potentially	ADV
eurjchem-2534	179	14	targeted	target	VERB
eurjchem-2534	179	15	drug	drug	NOUN
eurjchem-2534	179	16	delivery	delivery	NOUN
eurjchem-2534	179	17	.	.	PUNCT
eurjchem-2534	180	1	stability	stability	NOUN
eurjchem-2534	180	2	:	:	PUNCT
eurjchem-2534	180	3	glucolipids	glucolipid	NOUN
eurjchem-2534	180	4	can	can	AUX
eurjchem-2534	180	5	be	be	AUX
eurjchem-2534	180	6	prone	prone	ADJ
eurjchem-2534	180	7	to	to	ADP
eurjchem-2534	180	8	degradation	degradation	NOUN
eurjchem-2534	180	9	under	under	ADP
eurjchem-2534	180	10	certain	certain	ADJ
eurjchem-2534	180	11	conditions	condition	NOUN
eurjchem-2534	180	12	.	.	PUNCT
eurjchem-2534	181	1	limited	limited	ADJ
eurjchem-2534	181	2	versatility	versatility	NOUN
eurjchem-2534	181	3	:	:	PUNCT
eurjchem-2534	181	4	they	they	PRON
eurjchem-2534	181	5	may	may	AUX
eurjchem-2534	181	6	not	not	PART
eurjchem-2534	181	7	be	be	AUX
eurjchem-2534	181	8	suitable	suitable	ADJ
eurjchem-2534	181	9	for	for	ADP
eurjchem-2534	181	10	all	all	DET
eurjchem-2534	181	11	drug	drug	NOUN
eurjchem-2534	181	12	types	type	NOUN
eurjchem-2534	181	13	.	.	PUNCT
eurjchem-2534	182	1	nucleic	nucleic	ADJ
eurjchem-2534	182	2	acid	acid	NOUN
eurjchem-2534	182	3	aptamer	aptamer	NOUN
eurjchem-2534	182	4	[	[	X
eurjchem-2534	182	5	47	47	NUM
eurjchem-2534	182	6	]	]	X
eurjchem-2534	182	7	high	high	ADJ
eurjchem-2534	182	8	specificity	specificity	NOUN
eurjchem-2534	182	9	:	:	PUNCT
eurjchem-2534	182	10	aptamers	aptamer	NOUN
eurjchem-2534	182	11	can	can	AUX
eurjchem-2534	182	12	be	be	AUX
eurjchem-2534	182	13	designed	design	VERB
eurjchem-2534	182	14	to	to	PART
eurjchem-2534	182	15	bind	bind	VERB
eurjchem-2534	182	16	specific	specific	ADJ
eurjchem-2534	182	17	molecular	molecular	ADJ
eurjchem-2534	182	18	targets	target	NOUN
eurjchem-2534	182	19	,	,	PUNCT
eurjchem-2534	182	20	leading	lead	VERB
eurjchem-2534	182	21	to	to	ADP
eurjchem-2534	182	22	precise	precise	ADJ
eurjchem-2534	182	23	drug	drug	NOUN
eurjchem-2534	182	24	delivery	delivery	NOUN
eurjchem-2534	182	25	.	.	PUNCT
eurjchem-2534	183	1	small	small	ADJ
eurjchem-2534	183	2	size	size	NOUN
eurjchem-2534	183	3	:	:	PUNCT
eurjchem-2534	183	4	this	this	PRON
eurjchem-2534	183	5	can	can	AUX
eurjchem-2534	183	6	facilitate	facilitate	VERB
eurjchem-2534	183	7	better	well	ADJ
eurjchem-2534	183	8	tissue	tissue	NOUN
eurjchem-2534	183	9	penetration	penetration	NOUN
eurjchem-2534	183	10	and	and	CCONJ
eurjchem-2534	183	11	cellular	cellular	ADJ
eurjchem-2534	183	12	uptake	uptake	NOUN
eurjchem-2534	183	13	.	.	PUNCT
eurjchem-2534	184	1	biodegradability	biodegradability	NOUN
eurjchem-2534	184	2	:	:	PUNCT
eurjchem-2534	184	3	aptamers	aptamer	NOUN
eurjchem-2534	184	4	are	be	AUX
eurjchem-2534	184	5	biodegradable	biodegradable	ADJ
eurjchem-2534	184	6	,	,	PUNCT
eurjchem-2534	184	7	reducing	reduce	VERB
eurjchem-2534	184	8	toxicity	toxicity	NOUN
eurjchem-2534	184	9	concerns	concern	NOUN
eurjchem-2534	184	10	.	.	PUNCT
eurjchem-2534	185	1	susceptibility	susceptibility	NOUN
eurjchem-2534	185	2	to	to	ADP
eurjchem-2534	185	3	degradation	degradation	NOUN
eurjchem-2534	185	4	:	:	PUNCT
eurjchem-2534	185	5	aptamers	aptamer	NOUN
eurjchem-2534	185	6	can	can	AUX
eurjchem-2534	185	7	be	be	AUX
eurjchem-2534	185	8	degraded	degrade	VERB
eurjchem-2534	185	9	by	by	ADP
eurjchem-2534	185	10	nucleases	nuclease	NOUN
eurjchem-2534	185	11	in	in	ADP
eurjchem-2534	185	12	the	the	DET
eurjchem-2534	185	13	body	body	NOUN
eurjchem-2534	185	14	.	.	PUNCT
eurjchem-2534	186	1	cost	cost	NOUN
eurjchem-2534	186	2	:	:	PUNCT
eurjchem-2534	186	3	custom	custom	NOUN
eurjchem-2534	186	4	synthesis	synthesis	NOUN
eurjchem-2534	186	5	of	of	ADP
eurjchem-2534	186	6	aptamers	aptamer	NOUN
eurjchem-2534	186	7	can	can	AUX
eurjchem-2534	186	8	be	be	AUX
eurjchem-2534	186	9	costly	costly	ADJ
eurjchem-2534	186	10	and	and	CCONJ
eurjchem-2534	186	11	time	time	NOUN
eurjchem-2534	186	12	-	-	PUNCT
eurjchem-2534	186	13	consuming	consume	VERB
eurjchem-2534	186	14	.	.	PUNCT
eurjchem-2534	187	1	nucleic	nucleic	ADJ
eurjchem-2534	187	2	acid	acid	PROPN
eurjchem-2534	187	3	aptamer	aptamer	NOUN
eurjchem-2534	187	4	-	-	PUNCT
eurjchem-2534	187	5	dendrimer	dendrimer	NOUN
eurjchem-2534	187	6	[	[	X
eurjchem-2534	187	7	48	48	NUM
eurjchem-2534	187	8	]	]	PUNCT
eurjchem-2534	187	9	enhanced	enhanced	ADJ
eurjchem-2534	187	10	stability	stability	NOUN
eurjchem-2534	187	11	:	:	PUNCT
eurjchem-2534	187	12	dendrimers	dendrimer	NOUN
eurjchem-2534	187	13	provide	provide	VERB
eurjchem-2534	187	14	structural	structural	ADJ
eurjchem-2534	187	15	stability	stability	NOUN
eurjchem-2534	187	16	to	to	ADP
eurjchem-2534	187	17	aptamers	aptamer	NOUN
eurjchem-2534	187	18	,	,	PUNCT
eurjchem-2534	187	19	improving	improve	VERB
eurjchem-2534	187	20	resistance	resistance	NOUN
eurjchem-2534	187	21	to	to	ADP
eurjchem-2534	187	22	degradation	degradation	NOUN
eurjchem-2534	187	23	.	.	PUNCT
eurjchem-2534	188	1	controlled	control	VERB
eurjchem-2534	188	2	release	release	NOUN
eurjchem-2534	188	3	:	:	PUNCT
eurjchem-2534	188	4	dendrimers	dendrimer	NOUN
eurjchem-2534	188	5	can	can	AUX
eurjchem-2534	188	6	enable	enable	VERB
eurjchem-2534	188	7	a	a	DET
eurjchem-2534	188	8	controlled	control	VERB
eurjchem-2534	188	9	release	release	NOUN
eurjchem-2534	188	10	of	of	ADP
eurjchem-2534	188	11	the	the	DET
eurjchem-2534	188	12	drug	drug	NOUN
eurjchem-2534	188	13	at	at	ADP
eurjchem-2534	188	14	the	the	DET
eurjchem-2534	188	15	target	target	NOUN
eurjchem-2534	188	16	site	site	NOUN
eurjchem-2534	188	17	.	.	PUNCT
eurjchem-2534	189	1	increased	increase	VERB
eurjchem-2534	189	2	loading	loading	NOUN
eurjchem-2534	189	3	capacity	capacity	NOUN
eurjchem-2534	189	4	:	:	PUNCT
eurjchem-2534	189	5	dendrimers	dendrimer	NOUN
eurjchem-2534	189	6	offer	offer	VERB
eurjchem-2534	189	7	high	high	ADJ
eurjchem-2534	189	8	loading	loading	NOUN
eurjchem-2534	189	9	capacity	capacity	NOUN
eurjchem-2534	189	10	due	due	ADP
eurjchem-2534	189	11	to	to	ADP
eurjchem-2534	189	12	their	their	PRON
eurjchem-2534	189	13	branched	branched	ADJ
eurjchem-2534	189	14	structure	structure	NOUN
eurjchem-2534	189	15	.	.	PUNCT
eurjchem-2534	190	1	complexity	complexity	NOUN
eurjchem-2534	190	2	:	:	PUNCT
eurjchem-2534	190	3	the	the	DET
eurjchem-2534	190	4	combination	combination	NOUN
eurjchem-2534	190	5	of	of	ADP
eurjchem-2534	190	6	dendrimers	dendrimer	NOUN
eurjchem-2534	190	7	and	and	CCONJ
eurjchem-2534	190	8	aptamers	aptamer	NOUN
eurjchem-2534	190	9	can	can	AUX
eurjchem-2534	190	10	lead	lead	VERB
eurjchem-2534	190	11	to	to	ADP
eurjchem-2534	190	12	more	more	ADV
eurjchem-2534	190	13	complex	complex	ADJ
eurjchem-2534	190	14	synthesis	synthesis	NOUN
eurjchem-2534	190	15	and	and	CCONJ
eurjchem-2534	190	16	manufacturing	manufacturing	NOUN
eurjchem-2534	190	17	processes	process	NOUN
eurjchem-2534	190	18	.	.	PUNCT
eurjchem-2534	191	1	potential	potential	ADJ
eurjchem-2534	191	2	toxicity	toxicity	NOUN
eurjchem-2534	191	3	:	:	PUNCT
eurjchem-2534	191	4	some	some	DET
eurjchem-2534	191	5	dendrimers	dendrimer	NOUN
eurjchem-2534	191	6	may	may	AUX
eurjchem-2534	191	7	be	be	AUX
eurjchem-2534	191	8	toxic	toxic	ADJ
eurjchem-2534	191	9	or	or	CCONJ
eurjchem-2534	191	10	trigger	trigger	NOUN
eurjchem-2534	191	11	immune	immune	ADJ
eurjchem-2534	191	12	responses	response	NOUN
eurjchem-2534	191	13	.	.	PUNCT
eurjchem-2534	192	1	indirect	indirect	ADJ
eurjchem-2534	192	2	polymer	polymer	NOUN
eurjchem-2534	192	3	[	[	X
eurjchem-2534	192	4	57,58	57,58	NUM
eurjchem-2534	192	5	]	]	X
eurjchem-2534	192	6	versatility	versatility	NOUN
eurjchem-2534	192	7	:	:	PUNCT
eurjchem-2534	192	8	polymers	polymer	NOUN
eurjchem-2534	192	9	can	can	AUX
eurjchem-2534	192	10	be	be	AUX
eurjchem-2534	192	11	customized	customize	VERB
eurjchem-2534	192	12	for	for	ADP
eurjchem-2534	192	13	various	various	ADJ
eurjchem-2534	192	14	drug	drug	NOUN
eurjchem-2534	192	15	types	type	NOUN
eurjchem-2534	192	16	and	and	CCONJ
eurjchem-2534	192	17	release	release	NOUN
eurjchem-2534	192	18	profiles	profile	NOUN
eurjchem-2534	192	19	.	.	PUNCT
eurjchem-2534	193	1	controlled	control	VERB
eurjchem-2534	193	2	release	release	NOUN
eurjchem-2534	193	3	:	:	PUNCT
eurjchem-2534	193	4	polymers	polymer	NOUN
eurjchem-2534	193	5	can	can	AUX
eurjchem-2534	193	6	offer	offer	VERB
eurjchem-2534	193	7	tailored	tailor	VERB
eurjchem-2534	193	8	drug	drug	NOUN
eurjchem-2534	193	9	release	release	NOUN
eurjchem-2534	193	10	rates	rate	NOUN
eurjchem-2534	193	11	.	.	PUNCT
eurjchem-2534	194	1	stability	stability	NOUN
eurjchem-2534	194	2	:	:	PUNCT
eurjchem-2534	194	3	polymers	polymer	NOUN
eurjchem-2534	194	4	generally	generally	ADV
eurjchem-2534	194	5	provide	provide	VERB
eurjchem-2534	194	6	good	good	ADJ
eurjchem-2534	194	7	stability	stability	NOUN
eurjchem-2534	194	8	and	and	CCONJ
eurjchem-2534	194	9	protection	protection	NOUN
eurjchem-2534	194	10	for	for	ADP
eurjchem-2534	194	11	the	the	DET
eurjchem-2534	194	12	drug	drug	NOUN
eurjchem-2534	194	13	.	.	PUNCT
eurjchem-2534	195	1	biocompatibility	biocompatibility	NOUN
eurjchem-2534	195	2	:	:	PUNCT
eurjchem-2534	195	3	some	some	DET
eurjchem-2534	195	4	polymers	polymer	NOUN
eurjchem-2534	195	5	can	can	AUX
eurjchem-2534	195	6	cause	cause	VERB
eurjchem-2534	195	7	adverse	adverse	ADJ
eurjchem-2534	195	8	reactions	reaction	NOUN
eurjchem-2534	195	9	or	or	CCONJ
eurjchem-2534	195	10	inflammation	inflammation	NOUN
eurjchem-2534	195	11	.	.	PUNCT
eurjchem-2534	196	1	complexity	complexity	NOUN
eurjchem-2534	196	2	:	:	PUNCT
eurjchem-2534	196	3	the	the	DET
eurjchem-2534	196	4	variety	variety	NOUN
eurjchem-2534	196	5	of	of	ADP
eurjchem-2534	196	6	polymers	polymer	NOUN
eurjchem-2534	196	7	can	can	AUX
eurjchem-2534	196	8	require	require	VERB
eurjchem-2534	196	9	more	more	ADV
eurjchem-2534	196	10	extensive	extensive	ADJ
eurjchem-2534	196	11	testing	testing	NOUN
eurjchem-2534	196	12	for	for	ADP
eurjchem-2534	196	13	biocompatibility	biocompatibility	NOUN
eurjchem-2534	196	14	.	.	PUNCT
eurjchem-2534	197	1	dendrimer	dendrimer	PROPN
eurjchem-2534	198	1	[	[	X
eurjchem-2534	198	2	48,59	48,59	X
eurjchem-2534	198	3	]	]	X
eurjchem-2534	198	4	high	high	ADJ
eurjchem-2534	198	5	loading	loading	NOUN
eurjchem-2534	198	6	capacity	capacity	NOUN
eurjchem-2534	198	7	:	:	PUNCT
eurjchem-2534	198	8	dendrimers	dendrimer	NOUN
eurjchem-2534	198	9	’	'	PUNCT
eurjchem-2534	198	10	branched	branched	ADJ
eurjchem-2534	198	11	structure	structure	NOUN
eurjchem-2534	198	12	allows	allow	VERB
eurjchem-2534	198	13	for	for	ADP
eurjchem-2534	198	14	a	a	DET
eurjchem-2534	198	15	high	high	ADJ
eurjchem-2534	198	16	drug	drug	NOUN
eurjchem-2534	198	17	loading	loading	NOUN
eurjchem-2534	198	18	capacity	capacity	NOUN
eurjchem-2534	198	19	.	.	PUNCT
eurjchem-2534	199	1	precise	precise	ADJ
eurjchem-2534	199	2	delivery	delivery	NOUN
eurjchem-2534	199	3	:	:	PUNCT
eurjchem-2534	199	4	their	their	PRON
eurjchem-2534	199	5	defined	define	VERB
eurjchem-2534	199	6	structure	structure	NOUN
eurjchem-2534	199	7	can	can	AUX
eurjchem-2534	199	8	offer	offer	VERB
eurjchem-2534	199	9	precise	precise	ADJ
eurjchem-2534	199	10	drug	drug	NOUN
eurjchem-2534	199	11	delivery	delivery	NOUN
eurjchem-2534	199	12	and	and	CCONJ
eurjchem-2534	199	13	controlled	control	VERB
eurjchem-2534	199	14	release	release	NOUN
eurjchem-2534	199	15	.	.	PUNCT
eurjchem-2534	200	1	potential	potential	ADJ
eurjchem-2534	200	2	toxicity	toxicity	NOUN
eurjchem-2534	200	3	:	:	PUNCT
eurjchem-2534	200	4	certain	certain	ADJ
eurjchem-2534	200	5	dendrimers	dendrimer	NOUN
eurjchem-2534	200	6	can	can	AUX
eurjchem-2534	200	7	be	be	AUX
eurjchem-2534	200	8	toxic	toxic	ADJ
eurjchem-2534	200	9	,	,	PUNCT
eurjchem-2534	200	10	depending	depend	VERB
eurjchem-2534	200	11	on	on	ADP
eurjchem-2534	200	12	their	their	PRON
eurjchem-2534	200	13	structure	structure	NOUN
eurjchem-2534	200	14	and	and	CCONJ
eurjchem-2534	200	15	terminal	terminal	ADJ
eurjchem-2534	200	16	groups	group	NOUN
eurjchem-2534	200	17	.	.	PUNCT
eurjchem-2534	201	1	complex	complex	ADJ
eurjchem-2534	201	2	synthesis	synthesis	NOUN
eurjchem-2534	201	3	:	:	PUNCT
eurjchem-2534	201	4	dendrimer	dendrimer	PROPN
eurjchem-2534	201	5	production	production	NOUN
eurjchem-2534	201	6	can	can	AUX
eurjchem-2534	201	7	be	be	AUX
eurjchem-2534	201	8	complex	complex	ADJ
eurjchem-2534	201	9	and	and	CCONJ
eurjchem-2534	201	10	expensive	expensive	ADJ
eurjchem-2534	201	11	.	.	PUNCT
eurjchem-2534	202	1	albumin	albumin	ADJ
eurjchem-2534	202	2	[	[	X
eurjchem-2534	202	3	60,61	60,61	NOUN
eurjchem-2534	202	4	]	]	X
eurjchem-2534	202	5	biocompatibility	biocompatibility	NOUN
eurjchem-2534	202	6	:	:	PUNCT
eurjchem-2534	202	7	albumin	albumin	NOUN
eurjchem-2534	202	8	is	be	AUX
eurjchem-2534	202	9	a	a	DET
eurjchem-2534	202	10	natural	natural	ADJ
eurjchem-2534	202	11	protein	protein	NOUN
eurjchem-2534	202	12	,	,	PUNCT
eurjchem-2534	202	13	reducing	reduce	VERB
eurjchem-2534	202	14	the	the	DET
eurjchem-2534	202	15	risk	risk	NOUN
eurjchem-2534	202	16	of	of	ADP
eurjchem-2534	202	17	immune	immune	ADJ
eurjchem-2534	202	18	reactions	reaction	NOUN
eurjchem-2534	202	19	.	.	PUNCT
eurjchem-2534	203	1	prolonged	prolonged	ADJ
eurjchem-2534	203	2	circulation	circulation	NOUN
eurjchem-2534	203	3	:	:	PUNCT
eurjchem-2534	203	4	albumin	albumin	NOUN
eurjchem-2534	203	5	-	-	PUNCT
eurjchem-2534	203	6	based	base	VERB
eurjchem-2534	203	7	carriers	carrier	NOUN
eurjchem-2534	203	8	can	can	AUX
eurjchem-2534	203	9	extend	extend	VERB
eurjchem-2534	203	10	drug	drug	NOUN
eurjchem-2534	203	11	circulation	circulation	NOUN
eurjchem-2534	203	12	time	time	NOUN
eurjchem-2534	203	13	.	.	PUNCT
eurjchem-2534	204	1	reduced	reduced	ADJ
eurjchem-2534	204	2	toxicity	toxicity	NOUN
eurjchem-2534	204	3	:	:	PUNCT
eurjchem-2534	204	4	albumin	albumin	NOUN
eurjchem-2534	204	5	generally	generally	ADV
eurjchem-2534	204	6	has	have	VERB
eurjchem-2534	204	7	a	a	DET
eurjchem-2534	204	8	lower	low	ADJ
eurjchem-2534	204	9	toxicity	toxicity	NOUN
eurjchem-2534	204	10	profile	profile	NOUN
eurjchem-2534	204	11	.	.	PUNCT
eurjchem-2534	205	1	limited	limited	ADJ
eurjchem-2534	205	2	customization	customization	NOUN
eurjchem-2534	205	3	:	:	PUNCT
eurjchem-2534	205	4	albumin	albumin	PROPN
eurjchem-2534	205	5	’s	’s	PART
eurjchem-2534	205	6	structure	structure	NOUN
eurjchem-2534	205	7	might	might	AUX
eurjchem-2534	205	8	limit	limit	VERB
eurjchem-2534	205	9	the	the	DET
eurjchem-2534	205	10	customization	customization	NOUN
eurjchem-2534	205	11	options	option	NOUN
eurjchem-2534	205	12	for	for	ADP
eurjchem-2534	205	13	drug	drug	NOUN
eurjchem-2534	205	14	delivery	delivery	NOUN
eurjchem-2534	205	15	.	.	PUNCT
eurjchem-2534	206	1	stability	stability	NOUN
eurjchem-2534	206	2	concerns	concern	NOUN
eurjchem-2534	206	3	:	:	PUNCT
eurjchem-2534	206	4	under	under	ADP
eurjchem-2534	206	5	certain	certain	ADJ
eurjchem-2534	206	6	conditions	condition	NOUN
eurjchem-2534	206	7	,	,	PUNCT
eurjchem-2534	206	8	albumin	albumin	NOUN
eurjchem-2534	206	9	can	can	AUX
eurjchem-2534	206	10	denature	denature	NOUN
eurjchem-2534	206	11	,	,	PUNCT
eurjchem-2534	206	12	impacting	impact	VERB
eurjchem-2534	206	13	drug	drug	NOUN
eurjchem-2534	206	14	stability	stability	NOUN
eurjchem-2534	206	15	.	.	PUNCT
eurjchem-2534	207	1	phytosomes	phytosome	NOUN
eurjchem-2534	208	1	[	[	X
eurjchem-2534	208	2	51,62,63	51,62,63	X
eurjchem-2534	208	3	]	]	X
eurjchem-2534	208	4	enhanced	enhanced	ADJ
eurjchem-2534	208	5	bioavailability	bioavailability	NOUN
eurjchem-2534	208	6	:	:	PUNCT
eurjchem-2534	208	7	phytosomes	phytosome	NOUN
eurjchem-2534	208	8	can	can	AUX
eurjchem-2534	208	9	improve	improve	VERB
eurjchem-2534	208	10	the	the	DET
eurjchem-2534	208	11	absorption	absorption	NOUN
eurjchem-2534	208	12	and	and	CCONJ
eurjchem-2534	208	13	bioavailability	bioavailability	NOUN
eurjchem-2534	208	14	of	of	ADP
eurjchem-2534	208	15	phytochemicals	phytochemical	NOUN
eurjchem-2534	208	16	.	.	PUNCT
eurjchem-2534	209	1	biocompatibility	biocompatibility	NOUN
eurjchem-2534	209	2	:	:	PUNCT
eurjchem-2534	209	3	phytosomes	phytosome	NOUN
eurjchem-2534	209	4	are	be	AUX
eurjchem-2534	209	5	generally	generally	ADV
eurjchem-2534	209	6	biocompatible	biocompatible	ADJ
eurjchem-2534	209	7	and	and	CCONJ
eurjchem-2534	209	8	derived	derive	VERB
eurjchem-2534	209	9	from	from	ADP
eurjchem-2534	209	10	plant	plant	NOUN
eurjchem-2534	209	11	-	-	PUNCT
eurjchem-2534	209	12	based	base	VERB
eurjchem-2534	209	13	materials	material	NOUN
eurjchem-2534	209	14	.	.	PUNCT
eurjchem-2534	210	1	improved	improve	VERB
eurjchem-2534	210	2	solubility	solubility	NOUN
eurjchem-2534	210	3	:	:	PUNCT
eurjchem-2534	210	4	they	they	PRON
eurjchem-2534	210	5	can	can	AUX
eurjchem-2534	210	6	increase	increase	VERB
eurjchem-2534	210	7	the	the	DET
eurjchem-2534	210	8	solubility	solubility	NOUN
eurjchem-2534	210	9	of	of	ADP
eurjchem-2534	210	10	certain	certain	ADJ
eurjchem-2534	210	11	drugs	drug	NOUN
eurjchem-2534	210	12	.	.	PUNCT
eurjchem-2534	211	1	limited	limited	ADJ
eurjchem-2534	211	2	application	application	NOUN
eurjchem-2534	211	3	:	:	PUNCT
eurjchem-2534	211	4	phytosomes	phytosome	NOUN
eurjchem-2534	211	5	may	may	AUX
eurjchem-2534	211	6	be	be	AUX
eurjchem-2534	211	7	more	more	ADV
eurjchem-2534	211	8	effective	effective	ADJ
eurjchem-2534	211	9	for	for	ADP
eurjchem-2534	211	10	specific	specific	ADJ
eurjchem-2534	211	11	compounds	compound	NOUN
eurjchem-2534	211	12	,	,	PUNCT
eurjchem-2534	211	13	limiting	limit	VERB
eurjchem-2534	211	14	their	their	PRON
eurjchem-2534	211	15	broader	broad	ADJ
eurjchem-2534	211	16	use	use	NOUN
eurjchem-2534	211	17	.	.	PUNCT
eurjchem-2534	212	1	stability	stability	NOUN
eurjchem-2534	212	2	:	:	PUNCT
eurjchem-2534	212	3	they	they	PRON
eurjchem-2534	212	4	might	might	AUX
eurjchem-2534	212	5	degrade	degrade	VERB
eurjchem-2534	212	6	under	under	ADP
eurjchem-2534	212	7	certain	certain	ADJ
eurjchem-2534	212	8	environmental	environmental	ADJ
eurjchem-2534	212	9	conditions	condition	NOUN
eurjchem-2534	212	10	.	.	PUNCT
eurjchem-2534	213	1	liposome	liposome	VERB
eurjchem-2534	213	2	[	[	X
eurjchem-2534	213	3	53,54,64	53,54,64	NUM
eurjchem-2534	213	4	]	]	PUNCT
eurjchem-2534	213	5	versatility	versatility	NOUN
eurjchem-2534	213	6	:	:	PUNCT
eurjchem-2534	213	7	liposomes	liposome	NOUN
eurjchem-2534	213	8	can	can	AUX
eurjchem-2534	213	9	encapsulate	encapsulate	VERB
eurjchem-2534	213	10	a	a	DET
eurjchem-2534	213	11	wide	wide	ADJ
eurjchem-2534	213	12	range	range	NOUN
eurjchem-2534	213	13	of	of	ADP
eurjchem-2534	213	14	drugs	drug	NOUN
eurjchem-2534	213	15	,	,	PUNCT
eurjchem-2534	213	16	including	include	VERB
eurjchem-2534	213	17	hydrophilic	hydrophilic	NOUN
eurjchem-2534	213	18	and	and	CCONJ
eurjchem-2534	213	19	hydrophobic	hydrophobic	NOUN
eurjchem-2534	213	20	.	.	PUNCT
eurjchem-2534	214	1	biocompatibility	biocompatibility	NOUN
eurjchem-2534	214	2	:	:	PUNCT
eurjchem-2534	214	3	liposomes	liposome	NOUN
eurjchem-2534	214	4	are	be	AUX
eurjchem-2534	214	5	biocompatible	biocompatible	ADJ
eurjchem-2534	214	6	and	and	CCONJ
eurjchem-2534	214	7	biodegradable	biodegradable	ADJ
eurjchem-2534	214	8	.	.	PUNCT
eurjchem-2534	215	1	controlled	control	VERB
eurjchem-2534	215	2	release	release	NOUN
eurjchem-2534	215	3	:	:	PUNCT
eurjchem-2534	215	4	liposomes	liposome	NOUN
eurjchem-2534	215	5	can	can	AUX
eurjchem-2534	215	6	be	be	AUX
eurjchem-2534	215	7	designed	design	VERB
eurjchem-2534	215	8	for	for	ADP
eurjchem-2534	215	9	targeted	target	VERB
eurjchem-2534	215	10	and	and	CCONJ
eurjchem-2534	215	11	controlled	control	VERB
eurjchem-2534	215	12	drug	drug	NOUN
eurjchem-2534	215	13	release	release	NOUN
eurjchem-2534	215	14	.	.	PUNCT
eurjchem-2534	216	1	stability	stability	NOUN
eurjchem-2534	216	2	issues	issue	NOUN
eurjchem-2534	216	3	:	:	PUNCT
eurjchem-2534	216	4	liposomes	liposome	NOUN
eurjchem-2534	216	5	can	can	AUX
eurjchem-2534	216	6	be	be	AUX
eurjchem-2534	216	7	prone	prone	ADJ
eurjchem-2534	216	8	to	to	ADP
eurjchem-2534	216	9	leakage	leakage	NOUN
eurjchem-2534	216	10	and	and	CCONJ
eurjchem-2534	216	11	instability	instability	NOUN
eurjchem-2534	216	12	under	under	ADP
eurjchem-2534	216	13	certain	certain	ADJ
eurjchem-2534	216	14	conditions	condition	NOUN
eurjchem-2534	216	15	.	.	PUNCT
eurjchem-2534	217	1	cost	cost	NOUN
eurjchem-2534	217	2	:	:	PUNCT
eurjchem-2534	217	3	liposome	liposome	VERB
eurjchem-2534	217	4	production	production	NOUN
eurjchem-2534	217	5	and	and	CCONJ
eurjchem-2534	217	6	stabilization	stabilization	NOUN
eurjchem-2534	217	7	can	can	AUX
eurjchem-2534	217	8	be	be	AUX
eurjchem-2534	217	9	costly	costly	ADJ
eurjchem-2534	217	10	.	.	PUNCT
eurjchem-2534	218	1	exosomes	exosome	NOUN
eurjchem-2534	219	1	[	[	X
eurjchem-2534	219	2	55,65	55,65	X
eurjchem-2534	219	3	]	]	X
eurjchem-2534	219	4	natural	natural	ADJ
eurjchem-2534	219	5	origin	origin	NOUN
eurjchem-2534	219	6	:	:	PUNCT
eurjchem-2534	219	7	exosomes	exosome	NOUN
eurjchem-2534	219	8	are	be	AUX
eurjchem-2534	219	9	derived	derive	VERB
eurjchem-2534	219	10	from	from	ADP
eurjchem-2534	219	11	cells	cell	NOUN
eurjchem-2534	219	12	,	,	PUNCT
eurjchem-2534	219	13	which	which	PRON
eurjchem-2534	219	14	reduces	reduce	VERB
eurjchem-2534	219	15	immune	immune	ADJ
eurjchem-2534	219	16	reactions	reaction	NOUN
eurjchem-2534	219	17	.	.	PUNCT
eurjchem-2534	220	1	targeted	target	VERB
eurjchem-2534	220	2	delivery	delivery	NOUN
eurjchem-2534	220	3	:	:	PUNCT
eurjchem-2534	220	4	exosomes	exosome	NOUN
eurjchem-2534	220	5	can	can	AUX
eurjchem-2534	220	6	inherently	inherently	ADV
eurjchem-2534	220	7	target	target	VERB
eurjchem-2534	220	8	specific	specific	ADJ
eurjchem-2534	220	9	cells	cell	NOUN
eurjchem-2534	220	10	or	or	CCONJ
eurjchem-2534	220	11	tissues	tissue	NOUN
eurjchem-2534	220	12	.	.	PUNCT
eurjchem-2534	221	1	low	low	ADJ
eurjchem-2534	221	2	toxicity	toxicity	NOUN
eurjchem-2534	221	3	:	:	PUNCT
eurjchem-2534	221	4	exosomes	exosome	NOUN
eurjchem-2534	221	5	generally	generally	ADV
eurjchem-2534	221	6	exhibit	exhibit	VERB
eurjchem-2534	221	7	low	low	ADJ
eurjchem-2534	221	8	toxicity	toxicity	NOUN
eurjchem-2534	221	9	due	due	ADP
eurjchem-2534	221	10	to	to	ADP
eurjchem-2534	221	11	their	their	PRON
eurjchem-2534	221	12	natural	natural	ADJ
eurjchem-2534	221	13	origin	origin	NOUN
eurjchem-2534	221	14	.	.	PUNCT
eurjchem-2534	222	1	scalability	scalability	NOUN
eurjchem-2534	222	2	:	:	PUNCT
eurjchem-2534	222	3	the	the	DET
eurjchem-2534	222	4	production	production	NOUN
eurjchem-2534	222	5	and	and	CCONJ
eurjchem-2534	222	6	isolation	isolation	NOUN
eurjchem-2534	222	7	of	of	ADP
eurjchem-2534	222	8	exosomes	exosome	NOUN
eurjchem-2534	222	9	on	on	ADP
eurjchem-2534	222	10	a	a	DET
eurjchem-2534	222	11	large	large	ADJ
eurjchem-2534	222	12	scale	scale	NOUN
eurjchem-2534	222	13	can	can	AUX
eurjchem-2534	222	14	be	be	AUX
eurjchem-2534	222	15	challenging	challenge	VERB
eurjchem-2534	222	16	.	.	PUNCT
eurjchem-2534	223	1	heterogeneity	heterogeneity	NOUN
eurjchem-2534	223	2	:	:	PUNCT
eurjchem-2534	223	3	exosomes	exosome	NOUN
eurjchem-2534	223	4	from	from	ADP
eurjchem-2534	223	5	different	different	ADJ
eurjchem-2534	223	6	sources	source	NOUN
eurjchem-2534	223	7	may	may	AUX
eurjchem-2534	223	8	vary	vary	VERB
eurjchem-2534	223	9	in	in	ADP
eurjchem-2534	223	10	composition	composition	NOUN
eurjchem-2534	223	11	and	and	CCONJ
eurjchem-2534	223	12	properties	property	NOUN
eurjchem-2534	223	13	,	,	PUNCT
eurjchem-2534	223	14	affecting	affect	VERB
eurjchem-2534	223	15	consistency	consistency	NOUN
eurjchem-2534	223	16	.	.	PUNCT
eurjchem-2534	224	1	to	to	PART
eurjchem-2534	224	2	antibody	antibody	VERB
eurjchem-2534	224	3	modification	modification	NOUN
eurjchem-2534	224	4	.	.	PUNCT
eurjchem-2534	225	1	furthermore	furthermore	ADV
eurjchem-2534	225	2	,	,	PUNCT
eurjchem-2534	225	3	2	2	NUM
eurjchem-2534	225	4	mg	mg	NUM
eurjchem-2534	225	5	/	/	SYM
eurjchem-2534	225	6	kg	kg	PROPN
eurjchem-2534	225	7	celastrol	celastrol	NOUN
eurjchem-2534	225	8	delivered	deliver	VERB
eurjchem-2534	225	9	by	by	ADP
eurjchem-2534	225	10	pegylated	pegylate	VERB
eurjchem-2534	225	11	aptamer	aptamer	NOUN
eurjchem-2534	225	12	dendritic	dendritic	ADJ
eurjchem-2534	225	13	polymer	polymer	NOUN
eurjchem-2534	225	14	exhibited	exhibit	VERB
eurjchem-2534	225	15	significant	significant	ADJ
eurjchem-2534	225	16	anticancer	anticancer	NOUN
eurjchem-2534	225	17	efficiency	efficiency	NOUN
eurjchem-2534	225	18	(	(	PUNCT
eurjchem-2534	225	19	nearly	nearly	ADV
eurjchem-2534	225	20	92	92	NUM
eurjchem-2534	225	21	%	%	NOUN
eurjchem-2534	225	22	)	)	PUNCT
eurjchem-2534	225	23	with	with	ADP
eurjchem-2534	225	24	no	no	DET
eurjchem-2534	225	25	apparent	apparent	ADJ
eurjchem-2534	225	26	side	side	NOUN
eurjchem-2534	225	27	effects	effect	NOUN
eurjchem-2534	225	28	[	[	X
eurjchem-2534	225	29	50	50	NUM
eurjchem-2534	225	30	]	]	PUNCT
eurjchem-2534	225	31	.	.	PUNCT
eurjchem-2534	226	1	phytosomes	phytosome	NOUN
eurjchem-2534	226	2	are	be	AUX
eurjchem-2534	226	3	a	a	DET
eurjchem-2534	226	4	class	class	NOUN
eurjchem-2534	226	5	of	of	ADP
eurjchem-2534	226	6	lipid	lipid	NOUN
eurjchem-2534	226	7	-	-	PUNCT
eurjchem-2534	226	8	based	base	VERB
eurjchem-2534	226	9	nanoparticles	nanoparticle	NOUN
eurjchem-2534	226	10	designed	design	VERB
eurjchem-2534	226	11	to	to	PART
eurjchem-2534	226	12	enhance	enhance	VERB
eurjchem-2534	226	13	the	the	DET
eurjchem-2534	226	14	solubility	solubility	NOUN
eurjchem-2534	226	15	,	,	PUNCT
eurjchem-2534	226	16	absorption	absorption	NOUN
eurjchem-2534	226	17	,	,	PUNCT
eurjchem-2534	226	18	and	and	CCONJ
eurjchem-2534	226	19	bioavailability	bioavailability	NOUN
eurjchem-2534	226	20	of	of	ADP
eurjchem-2534	226	21	poorly	poorly	ADV
eurjchem-2534	226	22	soluble	soluble	ADJ
eurjchem-2534	226	23	compounds	compound	NOUN
eurjchem-2534	226	24	such	such	ADJ
eurjchem-2534	226	25	as	as	ADP
eurjchem-2534	226	26	celastrol	celastrol	NOUN
eurjchem-2534	226	27	.	.	PUNCT
eurjchem-2534	227	1	freag	freag	NOUN
eurjchem-2534	227	2	et	et	PROPN
eurjchem-2534	227	3	al	al	PROPN
eurjchem-2534	227	4	.	.	PROPN
eurjchem-2534	227	5	,	,	PUNCT
eurjchem-2534	227	6	for	for	ADP
eurjchem-2534	227	7	the	the	DET
eurjchem-2534	227	8	first	first	ADJ
eurjchem-2534	227	9	time	time	NOUN
eurjchem-2534	227	10	,	,	PUNCT
eurjchem-2534	227	11	focused	focus	VERB
eurjchem-2534	227	12	on	on	ADP
eurjchem-2534	227	13	developing	develop	VERB
eurjchem-2534	227	14	selfassembled	selfassemble	VERB
eurjchem-2534	227	15	phytosome	phytosome	NOUN
eurjchem-2534	227	16	nanocarriers	nanocarrier	NOUN
eurjchem-2534	227	17	for	for	ADP
eurjchem-2534	227	18	celastrol	celastrol	NOUN
eurjchem-2534	227	19	to	to	PART
eurjchem-2534	227	20	enhance	enhance	VERB
eurjchem-2534	227	21	its	its	PRON
eurjchem-2534	227	22	solubility	solubility	NOUN
eurjchem-2534	227	23	and	and	CCONJ
eurjchem-2534	227	24	oral	oral	ADJ
eurjchem-2534	227	25	bioavailability	bioavailability	NOUN
eurjchem-2534	227	26	[	[	X
eurjchem-2534	227	27	51	51	NUM
eurjchem-2534	227	28	]	]	PUNCT
eurjchem-2534	227	29	.	.	PUNCT
eurjchem-2534	228	1	comparative	comparative	ADJ
eurjchem-2534	228	2	in	in	ADP
eurjchem-2534	228	3	vitro	vitro	X
eurjchem-2534	228	4	release	release	NOUN
eurjchem-2534	228	5	studies	study	NOUN
eurjchem-2534	228	6	showed	show	VERB
eurjchem-2534	228	7	that	that	SCONJ
eurjchem-2534	228	8	phytosomes	phytosome	NOUN
eurjchem-2534	228	9	significantly	significantly	ADV
eurjchem-2534	228	10	enhanced	enhance	VERB
eurjchem-2534	228	11	the	the	DET
eurjchem-2534	228	12	release	release	NOUN
eurjchem-2534	228	13	of	of	ADP
eurjchem-2534	228	14	celastrol	celastrol	NOUN
eurjchem-2534	228	15	.	.	PUNCT
eurjchem-2534	229	1	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-2534	229	2	studies	study	NOUN
eurjchem-2534	229	3	in	in	ADP
eurjchem-2534	229	4	rabbits	rabbit	NOUN
eurjchem-2534	229	5	demonstrated	demonstrate	VERB
eurjchem-2534	229	6	that	that	SCONJ
eurjchem-2534	229	7	the	the	DET
eurjchem-2534	229	8	oral	oral	ADJ
eurjchem-2534	229	9	bioavailability	bioavailability	NOUN
eurjchem-2534	229	10	of	of	ADP
eurjchem-2534	229	11	celastrol	celastrol	NOUN
eurjchem-2534	229	12	in	in	ADP
eurjchem-2534	229	13	selfassembled	selfassembled	ADJ
eurjchem-2534	229	14	phytosome	phytosome	NOUN
eurjchem-2534	229	15	nanocarriers	nanocarrier	NOUN
eurjchem-2534	229	16	improved	improve	VERB
eurjchem-2534	229	17	significantly	significantly	ADV
eurjchem-2534	229	18	compared	compare	VERB
eurjchem-2534	229	19	to	to	ADP
eurjchem-2534	229	20	crude	crude	ADJ
eurjchem-2534	229	21	celastrol	celastrol	NOUN
eurjchem-2534	229	22	,	,	PUNCT
eurjchem-2534	229	23	with	with	ADP
eurjchem-2534	229	24	a	a	DET
eurjchem-2534	229	25	four	four	NUM
eurjchem-2534	229	26	-	-	ADJ
eurjchem-2534	229	27	fold	fold	ADJ
eurjchem-2534	229	28	increase	increase	NOUN
eurjchem-2534	229	29	in	in	ADP
eurjchem-2534	229	30	auc(08	auc(08	NOUN
eurjchem-2534	229	31	)	)	PUNCT
eurjchem-2534	229	32	and	and	CCONJ
eurjchem-2534	229	33	a	a	DET
eurjchem-2534	229	34	five	five	NUM
eurjchem-2534	229	35	-	-	ADJ
eurjchem-2534	229	36	fold	fold	ADJ
eurjchem-2534	229	37	increase	increase	NOUN
eurjchem-2534	229	38	in	in	ADP
eurjchem-2534	229	39	c(max	c(max	PROPN
eurjchem-2534	229	40	)	)	PUNCT
eurjchem-2534	229	41	.	.	PUNCT
eurjchem-2534	230	1	ultimately	ultimately	ADV
eurjchem-2534	230	2	,	,	PUNCT
eurjchem-2534	230	3	the	the	DET
eurjchem-2534	230	4	results	result	NOUN
eurjchem-2534	230	5	confirmed	confirm	VERB
eurjchem-2534	230	6	the	the	DET
eurjchem-2534	230	7	potential	potential	NOUN
eurjchem-2534	230	8	of	of	ADP
eurjchem-2534	230	9	phytosome	phytosome	ADJ
eurjchem-2534	230	10	nanocarriers	nanocarrier	NOUN
eurjchem-2534	230	11	to	to	PART
eurjchem-2534	230	12	improve	improve	VERB
eurjchem-2534	230	13	oral	oral	ADJ
eurjchem-2534	230	14	administration	administration	NOUN
eurjchem-2534	230	15	of	of	ADP
eurjchem-2534	230	16	celastrol	celastrol	NOUN
eurjchem-2534	230	17	[	[	X
eurjchem-2534	230	18	51	51	NUM
eurjchem-2534	230	19	]	]	PUNCT
eurjchem-2534	230	20	.	.	PUNCT
eurjchem-2534	231	1	albumin	albumin	PROPN
eurjchem-2534	231	2	is	be	AUX
eurjchem-2534	231	3	an	an	DET
eurjchem-2534	231	4	attractive	attractive	ADJ
eurjchem-2534	231	5	carrier	carrier	NOUN
eurjchem-2534	231	6	for	for	ADP
eurjchem-2534	231	7	the	the	DET
eurjchem-2534	231	8	delivery	delivery	NOUN
eurjchem-2534	231	9	of	of	ADP
eurjchem-2534	231	10	poorly	poorly	ADV
eurjchem-2534	231	11	water	water	NOUN
eurjchem-2534	231	12	-	-	PUNCT
eurjchem-2534	231	13	soluble	soluble	ADJ
eurjchem-2534	231	14	drugs	drug	NOUN
eurjchem-2534	231	15	.	.	PUNCT
eurjchem-2534	232	1	fan	fan	PROPN
eurjchem-2534	232	2	n	n	PROPN
eurjchem-2534	232	3	et	et	PROPN
eurjchem-2534	232	4	al	al	PROPN
eurjchem-2534	232	5	.	.	PROPN
eurjchem-2534	232	6	developed	develop	VERB
eurjchem-2534	232	7	a	a	DET
eurjchem-2534	232	8	biocompatible	biocompatible	ADJ
eurjchem-2534	232	9	albumin	albumin	NOUN
eurjchem-2534	232	10	-	-	PUNCT
eurjchem-2534	232	11	based	base	VERB
eurjchem-2534	232	12	nanoparticle	nanoparticle	NOUN
eurjchem-2534	232	13	carrier	carrier	NOUN
eurjchem-2534	232	14	system	system	NOUN
eurjchem-2534	232	15	for	for	ADP
eurjchem-2534	232	16	the	the	DET
eurjchem-2534	232	17	controlled	control	VERB
eurjchem-2534	232	18	release	release	NOUN
eurjchem-2534	232	19	of	of	ADP
eurjchem-2534	232	20	celastrol	celastrol	NOUN
eurjchem-2534	232	21	in	in	ADP
eurjchem-2534	232	22	diet	diet	NOUN
eurjchem-2534	232	23	-	-	PUNCT
eurjchem-2534	232	24	induced	induce	VERB
eurjchem-2534	232	25	obese	obese	ADJ
eurjchem-2534	232	26	mice	mouse	NOUN
eurjchem-2534	233	1	[	[	X
eurjchem-2534	233	2	52	52	NUM
eurjchem-2534	233	3	]	]	PUNCT
eurjchem-2534	233	4	.	.	PUNCT
eurjchem-2534	234	1	celastrol	celastrol	PROPN
eurjchem-2534	234	2	was	be	AUX
eurjchem-2534	234	3	loaded	load	VERB
eurjchem-2534	234	4	into	into	ADP
eurjchem-2534	234	5	bovine	bovine	NOUN
eurjchem-2534	234	6	serum	serum	NOUN
eurjchem-2534	234	7	albumin	albumin	PROPN
eurjchem-2534	234	8	(	(	PUNCT
eurjchem-2534	234	9	bsa	bsa	PROPN
eurjchem-2534	234	10	)	)	PUNCT
eurjchem-2534	234	11	nanoparticles	nanoparticle	NOUN
eurjchem-2534	234	12	,	,	PUNCT
eurjchem-2534	234	13	forming	form	VERB
eurjchem-2534	234	14	celastrol	celastrol	NOUN
eurjchem-2534	234	15	-	-	PUNCT
eurjchem-2534	234	16	bsa	bsa	PROPN
eurjchem-2534	234	17	-	-	PUNCT
eurjchem-2534	234	18	nps	nps	PROPN
eurjchem-2534	234	19	through	through	ADP
eurjchem-2534	234	20	high	high	ADJ
eurjchem-2534	234	21	-	-	PUNCT
eurjchem-2534	234	22	pressure	pressure	NOUN
eurjchem-2534	234	23	homogenization	homogenization	NOUN
eurjchem-2534	234	24	.	.	PUNCT
eurjchem-2534	235	1	celastrol	celastrol	NOUN
eurjchem-2534	235	2	-	-	PUNCT
eurjchem-2534	235	3	bsa	bsa	PROPN
eurjchem-2534	235	4	-	-	PUNCT
eurjchem-2534	235	5	nps	nps	PROPN
eurjchem-2534	235	6	exhibited	exhibit	VERB
eurjchem-2534	235	7	better	well	ADJ
eurjchem-2534	235	8	bioavailability	bioavailability	NOUN
eurjchem-2534	235	9	and	and	CCONJ
eurjchem-2534	235	10	in	in	ADP
eurjchem-2534	235	11	vivo	vivo	ADJ
eurjchem-2534	235	12	efficacy	efficacy	NOUN
eurjchem-2534	235	13	in	in	ADP
eurjchem-2534	235	14	the	the	DET
eurjchem-2534	235	15	treatment	treatment	NOUN
eurjchem-2534	235	16	of	of	ADP
eurjchem-2534	235	17	diet	diet	NOUN
eurjchem-2534	235	18	-	-	PUNCT
eurjchem-2534	235	19	induced	induce	VERB
eurjchem-2534	235	20	obesity	obesity	NOUN
eurjchem-2534	235	21	.	.	PUNCT
eurjchem-2534	236	1	importantly	importantly	ADV
eurjchem-2534	236	2	,	,	PUNCT
eurjchem-2534	236	3	this	this	DET
eurjchem-2534	236	4	albumin	albumin	NOUN
eurjchem-2534	236	5	-	-	PUNCT
eurjchem-2534	236	6	based	base	VERB
eurjchem-2534	236	7	nanoparticle	nanoparticle	NOUN
eurjchem-2534	236	8	system	system	NOUN
eurjchem-2534	236	9	could	could	AUX
eurjchem-2534	236	10	potentially	potentially	ADV
eurjchem-2534	236	11	be	be	AUX
eurjchem-2534	236	12	a	a	DET
eurjchem-2534	236	13	general	general	ADJ
eurjchem-2534	236	14	biocompatible	biocompatible	ADJ
eurjchem-2534	236	15	drug	drug	NOUN
eurjchem-2534	236	16	carrier	carrier	NOUN
eurjchem-2534	236	17	system	system	NOUN
eurjchem-2534	236	18	used	use	VERB
eurjchem-2534	236	19	for	for	ADP
eurjchem-2534	236	20	the	the	DET
eurjchem-2534	236	21	controlled	control	VERB
eurjchem-2534	236	22	release	release	NOUN
eurjchem-2534	236	23	of	of	ADP
eurjchem-2534	236	24	hydrophobic	hydrophobic	NOUN
eurjchem-2534	236	25	compounds	compound	NOUN
eurjchem-2534	236	26	,	,	PUNCT
eurjchem-2534	236	27	such	such	ADJ
eurjchem-2534	236	28	as	as	ADP
eurjchem-2534	236	29	celastrol	celastrol	NOUN
eurjchem-2534	236	30	,	,	PUNCT
eurjchem-2534	236	31	for	for	ADP
eurjchem-2534	236	32	the	the	DET
eurjchem-2534	236	33	treatment	treatment	NOUN
eurjchem-2534	236	34	of	of	ADP
eurjchem-2534	236	35	obesity	obesity	NOUN
eurjchem-2534	236	36	and	and	CCONJ
eurjchem-2534	236	37	nonalcoholic	nonalcoholic	NOUN
eurjchem-2534	236	38	fatty	fatty	NOUN
eurjchem-2534	236	39	liver	liver	NOUN
eurjchem-2534	236	40	disease	disease	NOUN
eurjchem-2534	236	41	[	[	X
eurjchem-2534	236	42	52	52	NUM
eurjchem-2534	236	43	]	]	PUNCT
eurjchem-2534	236	44	.	.	PUNCT
eurjchem-2534	237	1	liposomes	liposome	NOUN
eurjchem-2534	237	2	are	be	AUX
eurjchem-2534	237	3	a	a	DET
eurjchem-2534	237	4	type	type	NOUN
eurjchem-2534	237	5	of	of	ADP
eurjchem-2534	237	6	vesicular	vesicular	ADJ
eurjchem-2534	237	7	nanocarrier	nanocarrier	NOUN
eurjchem-2534	237	8	,	,	PUNCT
eurjchem-2534	237	9	and	and	CCONJ
eurjchem-2534	237	10	vesicular	vesicular	ADJ
eurjchem-2534	237	11	nanocarrier	nanocarrier	NOUN
eurjchem-2534	237	12	delivery	delivery	NOUN
eurjchem-2534	237	13	systems	system	NOUN
eurjchem-2534	237	14	can	can	AUX
eurjchem-2534	237	15	transport	transport	VERB
eurjchem-2534	237	16	both	both	PRON
eurjchem-2534	237	17	hydrophilic	hydrophilic	ADJ
eurjchem-2534	237	18	and	and	CCONJ
eurjchem-2534	237	19	hydrophobic	hydrophobic	NOUN
eurjchem-2534	237	20	drugs	drug	NOUN
eurjchem-2534	237	21	with	with	ADP
eurjchem-2534	237	22	low	low	ADJ
eurjchem-2534	237	23	toxicity	toxicity	NOUN
eurjchem-2534	237	24	,	,	PUNCT
eurjchem-2534	237	25	prolong	prolong	VERB
eurjchem-2534	237	26	the	the	DET
eurjchem-2534	237	27	drug	drug	NOUN
eurjchem-2534	237	28	’s	’s	PART
eurjchem-2534	237	29	half	half	ADJ
eurjchem-2534	237	30	-	-	PUNCT
eurjchem-2534	237	31	life	life	NOUN
eurjchem-2534	237	32	,	,	PUNCT
eurjchem-2534	237	33	and	and	CCONJ
eurjchem-2534	237	34	control	control	NOUN
eurjchem-2534	237	35	drug	drug	NOUN
eurjchem-2534	237	36	release	release	NOUN
eurjchem-2534	237	37	[	[	X
eurjchem-2534	237	38	53	53	NUM
eurjchem-2534	237	39	]	]	PUNCT
eurjchem-2534	237	40	.	.	PUNCT
eurjchem-2534	238	1	liposome	liposome	NOUN
eurjchem-2534	238	2	technology	technology	NOUN
eurjchem-2534	238	3	was	be	AUX
eurjchem-2534	238	4	the	the	DET
eurjchem-2534	238	5	first	first	ADJ
eurjchem-2534	238	6	therapeutic	therapeutic	ADJ
eurjchem-2534	238	7	carrier	carrier	NOUN
eurjchem-2534	238	8	approved	approve	VERB
eurjchem-2534	238	9	by	by	ADP
eurjchem-2534	238	10	the	the	DET
eurjchem-2534	238	11	us	us	PROPN
eurjchem-2534	238	12	food	food	NOUN
eurjchem-2534	238	13	and	and	CCONJ
eurjchem-2534	238	14	drug	drug	PROPN
eurjchem-2534	238	15	administration	administration	PROPN
eurjchem-2534	238	16	(	(	PUNCT
eurjchem-2534	238	17	fda	fda	PROPN
eurjchem-2534	238	18	)	)	PUNCT
eurjchem-2534	238	19	for	for	ADP
eurjchem-2534	238	20	the	the	DET
eurjchem-2534	238	21	delivery	delivery	NOUN
eurjchem-2534	238	22	of	of	ADP
eurjchem-2534	238	23	anticancer	anticancer	NOUN
eurjchem-2534	238	24	drugs	drug	NOUN
eurjchem-2534	238	25	.	.	PUNCT
eurjchem-2534	239	1	xinyan	xinyan	PROPN
eurjchem-2534	239	2	chen	chen	PROPN
eurjchem-2534	239	3	and	and	CCONJ
eurjchem-2534	239	4	colleagues	colleague	NOUN
eurjchem-2534	239	5	developed	develop	VERB
eurjchem-2534	239	6	galactosylated	galactosylated	ADJ
eurjchem-2534	239	7	liposomes	liposome	NOUN
eurjchem-2534	239	8	for	for	ADP
eurjchem-2534	239	9	the	the	DET
eurjchem-2534	239	10	delivery	delivery	NOUN
eurjchem-2534	239	11	of	of	ADP
eurjchem-2534	239	12	celastrol	celastrol	NOUN
eurjchem-2534	239	13	(	(	PUNCT
eurjchem-2534	239	14	c	c	NOUN
eurjchem-2534	239	15	-	-	PUNCT
eurjchem-2534	239	16	gpl	gpl	NOUN
eurjchem-2534	239	17	)	)	PUNCT
eurjchem-2534	239	18	using	use	VERB
eurjchem-2534	239	19	galactosemodified	galactosemodifie	VERB
eurjchem-2534	239	20	1	1	NUM
eurjchem-2534	239	21	,	,	PUNCT
eurjchem-2534	239	22	2	2	NUM
eurjchem-2534	239	23	-	-	PUNCT
eurjchem-2534	239	24	distearoyl	distearoyl	NOUN
eurjchem-2534	239	25	-	-	PUNCT
eurjchem-2534	239	26	sn	sn	NOUN
eurjchem-2534	239	27	-	-	PUNCT
eurjchem-2534	239	28	glycero-3	glycero-3	NOUN
eurjchem-2534	239	29	-	-	PUNCT
eurjchem-2534	239	30	phosphoethanolamine202	phosphoethanolamine202	NOUN
eurjchem-2534	239	31	ren	ren	PROPN
eurjchem-2534	239	32	and	and	CCONJ
eurjchem-2534	239	33	coghi	coghi	PROPN
eurjchem-2534	239	34	/	/	SYM
eurjchem-2534	239	35	european	european	PROPN
eurjchem-2534	239	36	journal	journal	PROPN
eurjchem-2534	239	37	of	of	ADP
eurjchem-2534	239	38	chemistry	chemistry	NOUN
eurjchem-2534	239	39	15	15	NUM
eurjchem-2534	239	40	(	(	PUNCT
eurjchem-2534	239	41	2	2	NUM
eurjchem-2534	239	42	)	)	PUNCT
eurjchem-2534	239	43	(	(	PUNCT
eurjchem-2534	239	44	2024	2024	NUM
eurjchem-2534	239	45	)	)	PUNCT
eurjchem-2534	239	46	194	194	NUM
eurjchem-2534	239	47	-	-	SYM
eurjchem-2534	239	48	204	204	NUM
eurjchem-2534	239	49	2024	2024	NUM
eurjchem-2534	239	50	–	–	PUNCT
eurjchem-2534	239	51	european	european	ADJ
eurjchem-2534	239	52	journal	journal	NOUN
eurjchem-2534	239	53	of	of	ADP
eurjchem-2534	239	54	chemistry	chemistry	NOUN
eurjchem-2534	239	55	–	–	PUNCT
eurjchem-2534	239	56	cc	cc	NOUN
eurjchem-2534	239	57	by	by	ADP
eurjchem-2534	239	58	nc	nc	PROPN
eurjchem-2534	239	59	–	–	PUNCT
eurjchem-2534	239	60	doi	doi	PROPN
eurjchem-2534	239	61	:	:	PUNCT
eurjchem-2534	239	62	10.5155	10.5155	NUM
eurjchem-2534	239	63	/	/	SYM
eurjchem-2534	239	64	eurjchem.15.2.194	eurjchem.15.2.194	NUM
eurjchem-2534	239	65	-	-	PUNCT
eurjchem-2534	239	66	204.2534	204.2534	NUM
eurjchem-2534	239	67	polyethylene	polyethylene	NOUN
eurjchem-2534	239	68	glycol	glycol	NOUN
eurjchem-2534	239	69	.	.	PUNCT
eurjchem-2534	240	1	c	c	X
eurjchem-2534	240	2	-	-	PUNCT
eurjchem-2534	240	3	gpl	gpl	NOUN
eurjchem-2534	240	4	increased	increase	VERB
eurjchem-2534	240	5	the	the	DET
eurjchem-2534	240	6	water	water	NOUN
eurjchem-2534	240	7	solubility	solubility	NOUN
eurjchem-2534	240	8	of	of	ADP
eurjchem-2534	240	9	celastrol	celastrol	NOUN
eurjchem-2534	240	10	and	and	CCONJ
eurjchem-2534	240	11	exhibited	exhibit	VERB
eurjchem-2534	240	12	a	a	DET
eurjchem-2534	240	13	high	high	ADJ
eurjchem-2534	240	14	encapsulation	encapsulation	NOUN
eurjchem-2534	240	15	rate	rate	NOUN
eurjchem-2534	240	16	,	,	PUNCT
eurjchem-2534	240	17	good	good	ADJ
eurjchem-2534	240	18	serum	serum	NOUN
eurjchem-2534	240	19	stability	stability	NOUN
eurjchem-2534	240	20	,	,	PUNCT
eurjchem-2534	240	21	and	and	CCONJ
eurjchem-2534	240	22	slow	slow	ADJ
eurjchem-2534	240	23	drug	drug	NOUN
eurjchem-2534	240	24	release	release	NOUN
eurjchem-2534	240	25	characteristics	characteristic	NOUN
eurjchem-2534	240	26	.	.	PUNCT
eurjchem-2534	241	1	in	in	ADP
eurjchem-2534	241	2	vitro	vitro	X
eurjchem-2534	241	3	studies	study	NOUN
eurjchem-2534	241	4	showed	show	VERB
eurjchem-2534	241	5	that	that	SCONJ
eurjchem-2534	241	6	c	c	NOUN
eurjchem-2534	241	7	-	-	PUNCT
eurjchem-2534	241	8	gpl	gpl	NOUN
eurjchem-2534	241	9	enhanced	enhance	VERB
eurjchem-2534	241	10	the	the	DET
eurjchem-2534	241	11	cellular	cellular	ADJ
eurjchem-2534	241	12	uptake	uptake	NOUN
eurjchem-2534	241	13	of	of	ADP
eurjchem-2534	241	14	celastrol	celastrol	NOUN
eurjchem-2534	241	15	through	through	ADP
eurjchem-2534	241	16	receptor	receptor	NOUN
eurjchem-2534	241	17	-	-	PUNCT
eurjchem-2534	241	18	mediated	mediate	VERB
eurjchem-2534	241	19	endocytosis	endocytosis	NOUN
eurjchem-2534	241	20	,	,	PUNCT
eurjchem-2534	241	21	thus	thus	ADV
eurjchem-2534	241	22	increasing	increase	VERB
eurjchem-2534	241	23	celastrol	celastrol	NOUN
eurjchem-2534	241	24	’s	’s	PART
eurjchem-2534	241	25	cytotoxicity	cytotoxicity	NOUN
eurjchem-2534	241	26	and	and	CCONJ
eurjchem-2534	241	27	cancer	cancer	NOUN
eurjchem-2534	241	28	cell	cell	NOUN
eurjchem-2534	241	29	apoptosis	apoptosis	NOUN
eurjchem-2534	241	30	.	.	PUNCT
eurjchem-2534	242	1	the	the	DET
eurjchem-2534	242	2	improved	improve	VERB
eurjchem-2534	242	3	therapeutic	therapeutic	ADJ
eurjchem-2534	242	4	effects	effect	NOUN
eurjchem-2534	242	5	of	of	ADP
eurjchem-2534	242	6	c	c	NOUN
eurjchem-2534	242	7	-	-	NOUN
eurjchem-2534	242	8	gpl	gpl	NOUN
eurjchem-2534	242	9	can	can	AUX
eurjchem-2534	242	10	be	be	AUX
eurjchem-2534	242	11	attributed	attribute	VERB
eurjchem-2534	242	12	to	to	ADP
eurjchem-2534	242	13	inhibition	inhibition	NOUN
eurjchem-2534	242	14	of	of	ADP
eurjchem-2534	242	15	akt	akt	PROPN
eurjchem-2534	242	16	activation	activation	NOUN
eurjchem-2534	242	17	,	,	PUNCT
eurjchem-2534	242	18	induction	induction	NOUN
eurjchem-2534	242	19	of	of	ADP
eurjchem-2534	242	20	cell	cell	NOUN
eurjchem-2534	242	21	apoptosis	apoptosis	NOUN
eurjchem-2534	242	22	,	,	PUNCT
eurjchem-2534	242	23	and	and	CCONJ
eurjchem-2534	242	24	delay	delay	NOUN
eurjchem-2534	242	25	of	of	ADP
eurjchem-2534	242	26	cell	cell	NOUN
eurjchem-2534	242	27	proliferation	proliferation	NOUN
eurjchem-2534	242	28	.	.	PUNCT
eurjchem-2534	243	1	importantly	importantly	ADV
eurjchem-2534	243	2	,	,	PUNCT
eurjchem-2534	243	3	c	c	X
eurjchem-2534	243	4	-	-	PUNCT
eurjchem-2534	243	5	gpl	gpl	NOUN
eurjchem-2534	243	6	exhibited	exhibit	VERB
eurjchem-2534	243	7	low	low	ADJ
eurjchem-2534	243	8	toxicity	toxicity	NOUN
eurjchem-2534	243	9	to	to	ADP
eurjchem-2534	243	10	normal	normal	ADJ
eurjchem-2534	243	11	tissues	tissue	NOUN
eurjchem-2534	243	12	and	and	CCONJ
eurjchem-2534	243	13	did	do	AUX
eurjchem-2534	243	14	not	not	PART
eurjchem-2534	243	15	cause	cause	VERB
eurjchem-2534	243	16	significant	significant	ADJ
eurjchem-2534	243	17	weight	weight	NOUN
eurjchem-2534	243	18	loss	loss	NOUN
eurjchem-2534	243	19	in	in	ADP
eurjchem-2534	243	20	mice	mouse	NOUN
eurjchem-2534	243	21	[	[	X
eurjchem-2534	243	22	54	54	NUM
eurjchem-2534	243	23	]	]	PUNCT
eurjchem-2534	243	24	.	.	PUNCT
eurjchem-2534	244	1	in	in	ADP
eurjchem-2534	244	2	addition	addition	NOUN
eurjchem-2534	244	3	to	to	ADP
eurjchem-2534	244	4	liposomes	liposome	NOUN
eurjchem-2534	244	5	,	,	PUNCT
eurjchem-2534	244	6	vesicular	vesicular	ADJ
eurjchem-2534	244	7	nanocarriers	nanocarrier	NOUN
eurjchem-2534	244	8	also	also	ADV
eurjchem-2534	244	9	include	include	VERB
eurjchem-2534	244	10	exosomes	exosome	NOUN
eurjchem-2534	244	11	.	.	PUNCT
eurjchem-2534	245	1	farrukh	farrukh	PROPN
eurjchem-2534	245	2	aqil	aqil	PROPN
eurjchem-2534	245	3	and	and	CCONJ
eurjchem-2534	245	4	colleagues	colleague	NOUN
eurjchem-2534	245	5	investigated	investigate	VERB
eurjchem-2534	245	6	the	the	DET
eurjchem-2534	245	7	effects	effect	NOUN
eurjchem-2534	245	8	of	of	ADP
eurjchem-2534	245	9	celastrol	celastrol	NOUN
eurjchem-2534	245	10	-	-	PUNCT
eurjchem-2534	245	11	loaded	load	VERB
eurjchem-2534	245	12	exosomes	exosome	NOUN
eurjchem-2534	245	13	on	on	ADP
eurjchem-2534	245	14	two	two	NUM
eurjchem-2534	245	15	nonsmall	nonsmall	NOUN
eurjchem-2534	245	16	cell	cell	NOUN
eurjchem-2534	245	17	lung	lung	NOUN
eurjchem-2534	245	18	cancer	cancer	NOUN
eurjchem-2534	245	19	(	(	PUNCT
eurjchem-2534	245	20	nsclc	nsclc	NOUN
eurjchem-2534	245	21	)	)	PUNCT
eurjchem-2534	245	22	cell	cell	NOUN
eurjchem-2534	245	23	lines	line	NOUN
eurjchem-2534	245	24	[	[	X
eurjchem-2534	245	25	55	55	NUM
eurjchem-2534	245	26	]	]	PUNCT
eurjchem-2534	245	27	.	.	PUNCT
eurjchem-2534	246	1	compared	compare	VERB
eurjchem-2534	246	2	to	to	ADP
eurjchem-2534	246	3	free	free	ADJ
eurjchem-2534	246	4	celastrol	celastrol	NOUN
eurjchem-2534	246	5	,	,	PUNCT
eurjchem-2534	246	6	celastrol	celastrol	NOUN
eurjchem-2534	246	7	-	-	PUNCT
eurjchem-2534	246	8	loaded	load	VERB
eurjchem-2534	246	9	exosomes	exosome	NOUN
eurjchem-2534	246	10	exhibited	exhibit	VERB
eurjchem-2534	246	11	enhanced	enhanced	ADJ
eurjchem-2534	246	12	antitumor	antitumor	PROPN
eurjchem-2534	246	13	efficacy	efficacy	NOUN
eurjchem-2534	246	14	in	in	ADP
eurjchem-2534	246	15	lung	lung	NOUN
eurjchem-2534	246	16	cancer	cancer	NOUN
eurjchem-2534	246	17	xenografts	xenograft	NOUN
eurjchem-2534	246	18	.	.	PUNCT
eurjchem-2534	247	1	the	the	DET
eurjchem-2534	247	2	data	datum	NOUN
eurjchem-2534	247	3	demonstrated	demonstrate	VERB
eurjchem-2534	247	4	the	the	DET
eurjchem-2534	247	5	chemotherapeutic	chemotherapeutic	ADJ
eurjchem-2534	247	6	potential	potential	NOUN
eurjchem-2534	247	7	of	of	ADP
eurjchem-2534	247	8	celastrol	celastrol	NOUN
eurjchem-2534	247	9	in	in	ADP
eurjchem-2534	247	10	lung	lung	NOUN
eurjchem-2534	247	11	cancer	cancer	NOUN
eurjchem-2534	247	12	,	,	PUNCT
eurjchem-2534	247	13	and	and	CCONJ
eurjchem-2534	247	14	the	the	DET
eurjchem-2534	247	15	exosome	exosome	PROPN
eurjchem-2534	247	16	formulation	formulation	NOUN
eurjchem-2534	247	17	enhanced	enhance	VERB
eurjchem-2534	247	18	its	its	PRON
eurjchem-2534	247	19	efficacy	efficacy	NOUN
eurjchem-2534	247	20	while	while	SCONJ
eurjchem-2534	247	21	reducing	reduce	VERB
eurjchem-2534	247	22	dose	dose	NOUN
eurjchem-2534	247	23	-	-	PUNCT
eurjchem-2534	247	24	related	relate	VERB
eurjchem-2534	247	25	toxicity	toxicity	NOUN
eurjchem-2534	247	26	[	[	X
eurjchem-2534	247	27	55	55	NUM
eurjchem-2534	247	28	]	]	PUNCT
eurjchem-2534	247	29	.	.	PUNCT
eurjchem-2534	248	1	4	4	X
eurjchem-2534	248	2	.	.	X
eurjchem-2534	248	3	future	future	ADJ
eurjchem-2534	248	4	directions	direction	NOUN
eurjchem-2534	248	5	and	and	CCONJ
eurjchem-2534	248	6	clinical	clinical	ADJ
eurjchem-2534	248	7	trials	trial	NOUN
eurjchem-2534	248	8	future	future	ADJ
eurjchem-2534	248	9	directions	direction	NOUN
eurjchem-2534	248	10	for	for	ADP
eurjchem-2534	248	11	celastrol	celastrol	NOUN
eurjchem-2534	248	12	research	research	NOUN
eurjchem-2534	248	13	are	be	AUX
eurjchem-2534	248	14	promising	promise	VERB
eurjchem-2534	248	15	,	,	PUNCT
eurjchem-2534	248	16	with	with	ADP
eurjchem-2534	248	17	several	several	ADJ
eurjchem-2534	248	18	key	key	ADJ
eurjchem-2534	248	19	areas	area	NOUN
eurjchem-2534	248	20	poised	poise	VERB
eurjchem-2534	248	21	for	for	ADP
eurjchem-2534	248	22	exploration	exploration	NOUN
eurjchem-2534	248	23	and	and	CCONJ
eurjchem-2534	248	24	innovation	innovation	NOUN
eurjchem-2534	248	25	.	.	PUNCT
eurjchem-2534	249	1	one	one	NUM
eurjchem-2534	249	2	of	of	ADP
eurjchem-2534	249	3	the	the	DET
eurjchem-2534	249	4	primary	primary	NOUN
eurjchem-2534	249	5	focuses	focus	NOUN
eurjchem-2534	249	6	will	will	AUX
eurjchem-2534	249	7	be	be	AUX
eurjchem-2534	249	8	on	on	ADP
eurjchem-2534	249	9	improving	improve	VERB
eurjchem-2534	249	10	the	the	DET
eurjchem-2534	249	11	drug	drug	NOUN
eurjchem-2534	249	12	’s	’s	PART
eurjchem-2534	249	13	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-2534	249	14	profile	profile	NOUN
eurjchem-2534	249	15	to	to	PART
eurjchem-2534	249	16	enhance	enhance	VERB
eurjchem-2534	249	17	its	its	PRON
eurjchem-2534	249	18	clinical	clinical	ADJ
eurjchem-2534	249	19	viability	viability	NOUN
eurjchem-2534	249	20	.	.	PUNCT
eurjchem-2534	250	1	this	this	PRON
eurjchem-2534	250	2	includes	include	VERB
eurjchem-2534	250	3	addressing	address	VERB
eurjchem-2534	250	4	challenges	challenge	NOUN
eurjchem-2534	250	5	such	such	ADJ
eurjchem-2534	250	6	as	as	ADP
eurjchem-2534	250	7	low	low	ADJ
eurjchem-2534	250	8	water	water	NOUN
eurjchem-2534	250	9	solubility	solubility	NOUN
eurjchem-2534	250	10	,	,	PUNCT
eurjchem-2534	250	11	toxicity	toxicity	NOUN
eurjchem-2534	250	12	,	,	PUNCT
eurjchem-2534	250	13	and	and	CCONJ
eurjchem-2534	250	14	stability	stability	NOUN
eurjchem-2534	250	15	,	,	PUNCT
eurjchem-2534	250	16	which	which	PRON
eurjchem-2534	250	17	have	have	AUX
eurjchem-2534	250	18	historically	historically	ADV
eurjchem-2534	250	19	hindered	hinder	VERB
eurjchem-2534	250	20	the	the	DET
eurjchem-2534	250	21	celastrol	celastrol	NOUN
eurjchem-2534	250	22	’s	’s	PART
eurjchem-2534	250	23	therapeutic	therapeutic	ADJ
eurjchem-2534	250	24	use	use	NOUN
eurjchem-2534	250	25	.	.	PUNCT
eurjchem-2534	251	1	additionally	additionally	ADV
eurjchem-2534	251	2	,	,	PUNCT
eurjchem-2534	251	3	the	the	DET
eurjchem-2534	251	4	integration	integration	NOUN
eurjchem-2534	251	5	of	of	ADP
eurjchem-2534	251	6	celastrol	celastrol	NOUN
eurjchem-2534	251	7	into	into	ADP
eurjchem-2534	251	8	combinatorial	combinatorial	ADJ
eurjchem-2534	251	9	therapies	therapy	NOUN
eurjchem-2534	251	10	with	with	ADP
eurjchem-2534	251	11	other	other	ADJ
eurjchem-2534	251	12	drugs	drug	NOUN
eurjchem-2534	251	13	has	have	VERB
eurjchem-2534	251	14	potential	potential	NOUN
eurjchem-2534	251	15	for	for	ADP
eurjchem-2534	251	16	synergistic	synergistic	ADJ
eurjchem-2534	251	17	effects	effect	NOUN
eurjchem-2534	251	18	,	,	PUNCT
eurjchem-2534	251	19	offering	offer	VERB
eurjchem-2534	251	20	more	more	ADV
eurjchem-2534	251	21	effective	effective	ADJ
eurjchem-2534	251	22	treatment	treatment	NOUN
eurjchem-2534	251	23	options	option	NOUN
eurjchem-2534	251	24	in	in	ADP
eurjchem-2534	251	25	antimalarial	antimalarial	ADJ
eurjchem-2534	251	26	therapy	therapy	NOUN
eurjchem-2534	251	27	[	[	X
eurjchem-2534	251	28	9,28	9,28	NUM
eurjchem-2534	251	29	]	]	PUNCT
eurjchem-2534	251	30	.	.	PUNCT
eurjchem-2534	252	1	in	in	ADP
eurjchem-2534	252	2	particular	particular	ADJ
eurjchem-2534	252	3	,	,	PUNCT
eurjchem-2534	252	4	celastrol	celastrol	NOUN
eurjchem-2534	252	5	exhibits	exhibit	VERB
eurjchem-2534	252	6	strong	strong	ADJ
eurjchem-2534	252	7	ic50	ic50	PROPN
eurjchem-2534	252	8	activity	activity	NOUN
eurjchem-2534	252	9	,	,	PUNCT
eurjchem-2534	252	10	with	with	ADP
eurjchem-2534	252	11	values	value	NOUN
eurjchem-2534	252	12	ranging	range	VERB
eurjchem-2534	252	13	from	from	ADP
eurjchem-2534	252	14	0.50	0.50	NUM
eurjchem-2534	252	15	to	to	ADP
eurjchem-2534	252	16	0.82	0.82	NUM
eurjchem-2534	252	17	µm	µm	NOUN
eurjchem-2534	252	18	against	against	ADP
eurjchem-2534	252	19	drugsensitive	drugsensitive	NOUN
eurjchem-2534	252	20	and	and	CCONJ
eurjchem-2534	252	21	drug	drug	NOUN
eurjchem-2534	252	22	-	-	PUNCT
eurjchem-2534	252	23	resistant	resistant	ADJ
eurjchem-2534	252	24	asexual	asexual	ADJ
eurjchem-2534	252	25	blood	blood	NOUN
eurjchem-2534	252	26	stage	stage	NOUN
eurjchem-2534	252	27	plasmodium	plasmodium	NOUN
eurjchem-2534	252	28	falciparum	falciparum	NOUN
eurjchem-2534	252	29	(	(	PUNCT
eurjchem-2534	252	30	pf	pf	NOUN
eurjchem-2534	252	31	)	)	PUNCT
eurjchem-2534	252	32	.	.	PUNCT
eurjchem-2534	253	1	it	it	PRON
eurjchem-2534	253	2	also	also	ADV
eurjchem-2534	253	3	shows	show	VERB
eurjchem-2534	253	4	ic50	ic50	PROPN
eurjchem-2534	253	5	levels	level	NOUN
eurjchem-2534	253	6	of	of	ADP
eurjchem-2534	253	7	1.16	1.16	NUM
eurjchem-2534	253	8	and	and	CCONJ
eurjchem-2534	253	9	0.28	0.28	NUM
eurjchem-2534	253	10	µm	µm	NOUN
eurjchem-2534	253	11	against	against	ADP
eurjchem-2534	253	12	immature	immature	ADJ
eurjchem-2534	253	13	and	and	CCONJ
eurjchem-2534	253	14	late	late	ADJ
eurjchem-2534	253	15	-	-	PUNCT
eurjchem-2534	253	16	stage	stage	NOUN
eurjchem-2534	253	17	pf	pf	ADP
eurjchem-2534	253	18	nf54	nf54	PROPN
eurjchem-2534	253	19	gametocytes	gametocyte	NOUN
eurjchem-2534	253	20	,	,	PUNCT
eurjchem-2534	253	21	respectively	respectively	ADV
eurjchem-2534	253	22	.	.	PUNCT
eurjchem-2534	254	1	when	when	SCONJ
eurjchem-2534	254	2	combined	combine	VERB
eurjchem-2534	254	3	with	with	ADP
eurjchem-2534	254	4	the	the	DET
eurjchem-2534	254	5	known	know	VERB
eurjchem-2534	254	6	antimalarial	antimalarial	ADJ
eurjchem-2534	254	7	drugs	drug	NOUN
eurjchem-2534	254	8	artemisone	artemisone	NOUN
eurjchem-2534	254	9	or	or	CCONJ
eurjchem-2534	254	10	methylene	methylene	NOUN
eurjchem-2534	254	11	blue	blue	NOUN
eurjchem-2534	254	12	,	,	PUNCT
eurjchem-2534	254	13	celastrol	celastrol	NOUN
eurjchem-2534	254	14	’s	’s	PART
eurjchem-2534	254	15	effects	effect	NOUN
eurjchem-2534	254	16	against	against	ADP
eurjchem-2534	254	17	asexual	asexual	ADJ
eurjchem-2534	254	18	blood	blood	NOUN
eurjchem-2534	254	19	stage	stage	NOUN
eurjchem-2534	254	20	pf	pf	PROPN
eurjchem-2534	254	21	are	be	AUX
eurjchem-2534	254	22	additive	additive	ADJ
eurjchem-2534	254	23	,	,	PUNCT
eurjchem-2534	254	24	suggesting	suggest	VERB
eurjchem-2534	254	25	the	the	DET
eurjchem-2534	254	26	potential	potential	NOUN
eurjchem-2534	254	27	for	for	ADP
eurjchem-2534	254	28	synergistic	synergistic	ADJ
eurjchem-2534	254	29	treatment	treatment	NOUN
eurjchem-2534	254	30	strategies	strategy	NOUN
eurjchem-2534	254	31	[	[	X
eurjchem-2534	254	32	9	9	NUM
eurjchem-2534	254	33	]	]	PUNCT
eurjchem-2534	254	34	.	.	PUNCT
eurjchem-2534	255	1	as	as	SCONJ
eurjchem-2534	255	2	research	research	NOUN
eurjchem-2534	255	3	progresses	progress	NOUN
eurjchem-2534	255	4	,	,	PUNCT
eurjchem-2534	255	5	understanding	understand	VERB
eurjchem-2534	255	6	the	the	DET
eurjchem-2534	255	7	molecular	molecular	ADJ
eurjchem-2534	255	8	mechanisms	mechanism	NOUN
eurjchem-2534	255	9	underlying	underlie	VERB
eurjchem-2534	255	10	celastrol	celastrol	NOUN
eurjchem-2534	255	11	’s	’s	PART
eurjchem-2534	255	12	action	action	NOUN
eurjchem-2534	255	13	will	will	AUX
eurjchem-2534	255	14	be	be	AUX
eurjchem-2534	255	15	vital	vital	ADJ
eurjchem-2534	255	16	,	,	PUNCT
eurjchem-2534	255	17	providing	provide	VERB
eurjchem-2534	255	18	insights	insight	NOUN
eurjchem-2534	255	19	that	that	PRON
eurjchem-2534	255	20	could	could	AUX
eurjchem-2534	255	21	lead	lead	VERB
eurjchem-2534	255	22	to	to	ADP
eurjchem-2534	255	23	new	new	ADJ
eurjchem-2534	255	24	therapeutic	therapeutic	ADJ
eurjchem-2534	255	25	targets	target	NOUN
eurjchem-2534	255	26	and	and	CCONJ
eurjchem-2534	255	27	strategies	strategy	NOUN
eurjchem-2534	255	28	.	.	PUNCT
eurjchem-2534	256	1	ultimately	ultimately	ADV
eurjchem-2534	256	2	,	,	PUNCT
eurjchem-2534	256	3	these	these	DET
eurjchem-2534	256	4	future	future	ADJ
eurjchem-2534	256	5	directions	direction	NOUN
eurjchem-2534	256	6	could	could	AUX
eurjchem-2534	256	7	significantly	significantly	ADV
eurjchem-2534	256	8	impact	impact	VERB
eurjchem-2534	256	9	the	the	DET
eurjchem-2534	256	10	field	field	NOUN
eurjchem-2534	256	11	of	of	ADP
eurjchem-2534	256	12	drug	drug	NOUN
eurjchem-2534	256	13	development	development	NOUN
eurjchem-2534	256	14	,	,	PUNCT
eurjchem-2534	256	15	bringing	bring	VERB
eurjchem-2534	256	16	celastrol	celastrol	NOUN
eurjchem-2534	256	17	-	-	PUNCT
eurjchem-2534	256	18	based	base	VERB
eurjchem-2534	256	19	treatments	treatment	NOUN
eurjchem-2534	256	20	closer	close	ADV
eurjchem-2534	256	21	to	to	ADP
eurjchem-2534	256	22	clinical	clinical	ADJ
eurjchem-2534	256	23	application	application	NOUN
eurjchem-2534	256	24	and	and	CCONJ
eurjchem-2534	256	25	offering	offer	VERB
eurjchem-2534	256	26	hope	hope	NOUN
eurjchem-2534	256	27	for	for	ADP
eurjchem-2534	256	28	patients	patient	NOUN
eurjchem-2534	256	29	with	with	ADP
eurjchem-2534	256	30	challenging	challenging	ADJ
eurjchem-2534	256	31	medical	medical	ADJ
eurjchem-2534	256	32	conditions	condition	NOUN
eurjchem-2534	256	33	.	.	PUNCT
eurjchem-2534	257	1	4.1	4.1	NUM
eurjchem-2534	257	2	.	.	PUNCT
eurjchem-2534	257	3	completed	complete	VERB
eurjchem-2534	257	4	and	and	CCONJ
eurjchem-2534	257	5	ongoing	ongoing	ADJ
eurjchem-2534	257	6	clinical	clinical	ADJ
eurjchem-2534	257	7	trials	trial	NOUN
eurjchem-2534	257	8	the	the	DET
eurjchem-2534	257	9	exploration	exploration	NOUN
eurjchem-2534	257	10	of	of	ADP
eurjchem-2534	257	11	celastrol	celastrol	NOUN
eurjchem-2534	257	12	in	in	ADP
eurjchem-2534	257	13	clinical	clinical	ADJ
eurjchem-2534	257	14	trials	trial	NOUN
eurjchem-2534	257	15	involves	involve	VERB
eurjchem-2534	257	16	testing	test	VERB
eurjchem-2534	257	17	its	its	PRON
eurjchem-2534	257	18	safety	safety	NOUN
eurjchem-2534	257	19	,	,	PUNCT
eurjchem-2534	257	20	efficacy	efficacy	NOUN
eurjchem-2534	257	21	,	,	PUNCT
eurjchem-2534	257	22	dosing	dosing	NOUN
eurjchem-2534	257	23	,	,	PUNCT
eurjchem-2534	257	24	and	and	CCONJ
eurjchem-2534	257	25	overall	overall	ADJ
eurjchem-2534	257	26	therapeutic	therapeutic	ADJ
eurjchem-2534	257	27	potential	potential	NOUN
eurjchem-2534	257	28	in	in	ADP
eurjchem-2534	257	29	humans	human	NOUN
eurjchem-2534	257	30	.	.	PUNCT
eurjchem-2534	258	1	despite	despite	SCONJ
eurjchem-2534	258	2	its	its	PRON
eurjchem-2534	258	3	promise	promise	NOUN
eurjchem-2534	258	4	,	,	PUNCT
eurjchem-2534	258	5	celastrol	celastrol	NOUN
eurjchem-2534	258	6	’s	’s	PART
eurjchem-2534	258	7	transition	transition	NOUN
eurjchem-2534	258	8	from	from	ADP
eurjchem-2534	258	9	preclinical	preclinical	ADJ
eurjchem-2534	258	10	studies	study	NOUN
eurjchem-2534	258	11	to	to	ADP
eurjchem-2534	258	12	human	human	ADJ
eurjchem-2534	258	13	trials	trial	NOUN
eurjchem-2534	258	14	has	have	AUX
eurjchem-2534	258	15	faced	face	VERB
eurjchem-2534	258	16	challenges	challenge	NOUN
eurjchem-2534	258	17	,	,	PUNCT
eurjchem-2534	258	18	mainly	mainly	ADV
eurjchem-2534	258	19	due	due	ADP
eurjchem-2534	258	20	to	to	ADP
eurjchem-2534	258	21	its	its	PRON
eurjchem-2534	258	22	potential	potential	ADJ
eurjchem-2534	258	23	side	side	NOUN
eurjchem-2534	258	24	effects	effect	NOUN
eurjchem-2534	258	25	and	and	CCONJ
eurjchem-2534	258	26	toxicity	toxicity	NOUN
eurjchem-2534	258	27	.	.	PUNCT
eurjchem-2534	259	1	the	the	DET
eurjchem-2534	259	2	clinical	clinical	ADJ
eurjchem-2534	259	3	trials	trial	NOUN
eurjchem-2534	259	4	with	with	ADP
eurjchem-2534	259	5	celastrol	celastrol	NOUN
eurjchem-2534	259	6	aim	aim	VERB
eurjchem-2534	259	7	to	to	PART
eurjchem-2534	259	8	assess	assess	VERB
eurjchem-2534	259	9	whether	whether	SCONJ
eurjchem-2534	259	10	these	these	DET
eurjchem-2534	259	11	risks	risk	NOUN
eurjchem-2534	259	12	can	can	AUX
eurjchem-2534	259	13	be	be	AUX
eurjchem-2534	259	14	mitigated	mitigate	VERB
eurjchem-2534	259	15	through	through	ADP
eurjchem-2534	259	16	innovative	innovative	ADJ
eurjchem-2534	259	17	drug	drug	NOUN
eurjchem-2534	259	18	delivery	delivery	NOUN
eurjchem-2534	259	19	systems	system	NOUN
eurjchem-2534	259	20	,	,	PUNCT
eurjchem-2534	259	21	dosage	dosage	NOUN
eurjchem-2534	259	22	adjustments	adjustment	NOUN
eurjchem-2534	259	23	,	,	PUNCT
eurjchem-2534	259	24	or	or	CCONJ
eurjchem-2534	259	25	other	other	ADJ
eurjchem-2534	259	26	methods	method	NOUN
eurjchem-2534	259	27	.	.	PUNCT
eurjchem-2534	260	1	there	there	PRON
eurjchem-2534	260	2	are	be	VERB
eurjchem-2534	260	3	ongoing	ongoing	ADJ
eurjchem-2534	260	4	clinical	clinical	ADJ
eurjchem-2534	260	5	trials	trial	NOUN
eurjchem-2534	260	6	investigating	investigate	VERB
eurjchem-2534	260	7	celastrol	celastrol	NOUN
eurjchem-2534	260	8	for	for	ADP
eurjchem-2534	260	9	various	various	ADJ
eurjchem-2534	260	10	applications	application	NOUN
eurjchem-2534	260	11	[	[	X
eurjchem-2534	260	12	66,67	66,67	ADP
eurjchem-2534	260	13	]	]	PUNCT
eurjchem-2534	260	14	.	.	PUNCT
eurjchem-2534	261	1	some	some	DET
eurjchem-2534	261	2	studies	study	NOUN
eurjchem-2534	261	3	focus	focus	VERB
eurjchem-2534	261	4	on	on	ADP
eurjchem-2534	261	5	its	its	PRON
eurjchem-2534	261	6	role	role	NOUN
eurjchem-2534	261	7	in	in	ADP
eurjchem-2534	261	8	the	the	DET
eurjchem-2534	261	9	management	management	NOUN
eurjchem-2534	261	10	of	of	ADP
eurjchem-2534	261	11	obesity	obesity	NOUN
eurjchem-2534	261	12	,	,	PUNCT
eurjchem-2534	261	13	where	where	SCONJ
eurjchem-2534	261	14	celastrol	celastrol	NOUN
eurjchem-2534	261	15	is	be	AUX
eurjchem-2534	261	16	believed	believe	VERB
eurjchem-2534	261	17	to	to	PART
eurjchem-2534	261	18	influence	influence	VERB
eurjchem-2534	261	19	satiety	satiety	NOUN
eurjchem-2534	261	20	and	and	CCONJ
eurjchem-2534	261	21	reduce	reduce	VERB
eurjchem-2534	261	22	body	body	NOUN
eurjchem-2534	261	23	weight	weight	NOUN
eurjchem-2534	261	24	[	[	X
eurjchem-2534	261	25	10	10	NUM
eurjchem-2534	261	26	]	]	PUNCT
eurjchem-2534	261	27	.	.	PUNCT
eurjchem-2534	262	1	other	other	ADJ
eurjchem-2534	262	2	trials	trial	NOUN
eurjchem-2534	262	3	examined	examine	VERB
eurjchem-2534	262	4	its	its	PRON
eurjchem-2534	262	5	anticancer	anticancer	NOUN
eurjchem-2534	262	6	properties	property	NOUN
eurjchem-2534	262	7	,	,	PUNCT
eurjchem-2534	262	8	looking	look	VERB
eurjchem-2534	262	9	at	at	ADP
eurjchem-2534	262	10	its	its	PRON
eurjchem-2534	262	11	ability	ability	NOUN
eurjchem-2534	262	12	to	to	PART
eurjchem-2534	262	13	inhibit	inhibit	VERB
eurjchem-2534	262	14	tumor	tumor	NOUN
eurjchem-2534	262	15	growth	growth	NOUN
eurjchem-2534	262	16	and	and	CCONJ
eurjchem-2534	262	17	promote	promote	VERB
eurjchem-2534	262	18	cancer	cancer	NOUN
eurjchem-2534	262	19	cell	cell	NOUN
eurjchem-2534	262	20	apoptosis	apoptosis	NOUN
eurjchem-2534	262	21	[	[	X
eurjchem-2534	262	22	68	68	NUM
eurjchem-2534	262	23	]	]	PUNCT
eurjchem-2534	262	24	and	and	CCONJ
eurjchem-2534	262	25	diabetes	diabete	VERB
eurjchem-2534	262	26	[	[	X
eurjchem-2534	262	27	69	69	NUM
eurjchem-2534	262	28	]	]	PUNCT
eurjchem-2534	262	29	.	.	PUNCT
eurjchem-2534	263	1	clinical	clinical	ADJ
eurjchem-2534	263	2	trials	trial	NOUN
eurjchem-2534	263	3	are	be	AUX
eurjchem-2534	263	4	also	also	ADV
eurjchem-2534	263	5	exploring	explore	VERB
eurjchem-2534	263	6	its	its	PRON
eurjchem-2534	263	7	effects	effect	NOUN
eurjchem-2534	263	8	on	on	ADP
eurjchem-2534	263	9	autoimmune	autoimmune	ADJ
eurjchem-2534	263	10	diseases	disease	NOUN
eurjchem-2534	263	11	,	,	PUNCT
eurjchem-2534	263	12	such	such	ADJ
eurjchem-2534	263	13	as	as	ADP
eurjchem-2534	263	14	crohn	crohn	PROPN
eurjchem-2534	263	15	’s	’s	PART
eurjchem-2534	263	16	disease	disease	NOUN
eurjchem-2534	263	17	[	[	X
eurjchem-2534	263	18	70	70	NUM
eurjchem-2534	263	19	]	]	PUNCT
eurjchem-2534	263	20	and	and	CCONJ
eurjchem-2534	263	21	rheumatoid	rheumatoid	VERB
eurjchem-2534	263	22	arthritis	arthritis	NOUN
eurjchem-2534	263	23	[	[	X
eurjchem-2534	263	24	65,71,72	65,71,72	NOUN
eurjchem-2534	263	25	]	]	PUNCT
eurjchem-2534	263	26	,	,	PUNCT
eurjchem-2534	263	27	to	to	PART
eurjchem-2534	263	28	determine	determine	VERB
eurjchem-2534	263	29	whether	whether	SCONJ
eurjchem-2534	263	30	celastrol	celastrol	NOUN
eurjchem-2534	263	31	can	can	AUX
eurjchem-2534	263	32	reduce	reduce	VERB
eurjchem-2534	263	33	inflammation	inflammation	NOUN
eurjchem-2534	263	34	and	and	CCONJ
eurjchem-2534	263	35	alleviate	alleviate	VERB
eurjchem-2534	263	36	symptoms	symptom	NOUN
eurjchem-2534	263	37	.	.	PUNCT
eurjchem-2534	264	1	clinical	clinical	ADJ
eurjchem-2534	264	2	trials	trial	NOUN
eurjchem-2534	264	3	with	with	ADP
eurjchem-2534	264	4	celastrol	celastrol	NOUN
eurjchem-2534	264	5	must	must	AUX
eurjchem-2534	264	6	address	address	VERB
eurjchem-2534	264	7	several	several	ADJ
eurjchem-2534	264	8	key	key	ADJ
eurjchem-2534	264	9	challenges	challenge	NOUN
eurjchem-2534	264	10	:	:	PUNCT
eurjchem-2534	264	11	(	(	PUNCT
eurjchem-2534	264	12	i	i	NOUN
eurjchem-2534	264	13	)	)	PUNCT
eurjchem-2534	264	14	toxicity	toxicity	NOUN
eurjchem-2534	264	15	and	and	CCONJ
eurjchem-2534	264	16	side	side	NOUN
eurjchem-2534	264	17	effects	effect	NOUN
eurjchem-2534	264	18	:	:	PUNCT
eurjchem-2534	264	19	celastrol	celastrol	PROPN
eurjchem-2534	264	20	’s	’s	PART
eurjchem-2534	264	21	hepatotoxicity	hepatotoxicity	NOUN
eurjchem-2534	264	22	,	,	PUNCT
eurjchem-2534	264	23	cytotoxicity	cytotoxicity	NOUN
eurjchem-2534	264	24	,	,	PUNCT
eurjchem-2534	264	25	and	and	CCONJ
eurjchem-2534	264	26	overall	overall	ADJ
eurjchem-2534	264	27	safety	safety	NOUN
eurjchem-2534	264	28	profile	profile	NOUN
eurjchem-2534	264	29	require	require	VERB
eurjchem-2534	264	30	careful	careful	ADJ
eurjchem-2534	264	31	monitoring	monitoring	NOUN
eurjchem-2534	264	32	and	and	CCONJ
eurjchem-2534	264	33	control	control	NOUN
eurjchem-2534	264	34	to	to	PART
eurjchem-2534	264	35	ensure	ensure	VERB
eurjchem-2534	264	36	patient	patient	ADJ
eurjchem-2534	264	37	safety	safety	NOUN
eurjchem-2534	264	38	;	;	PUNCT
eurjchem-2534	264	39	(	(	PUNCT
eurjchem-2534	264	40	ii	ii	NOUN
eurjchem-2534	264	41	)	)	PUNCT
eurjchem-2534	264	42	bioavailability	bioavailability	NOUN
eurjchem-2534	264	43	and	and	CCONJ
eurjchem-2534	264	44	solubility	solubility	NOUN
eurjchem-2534	264	45	:	:	PUNCT
eurjchem-2534	264	46	celastrol	celastrol	PROPN
eurjchem-2534	264	47	’s	’s	PART
eurjchem-2534	264	48	low	low	ADJ
eurjchem-2534	264	49	bioavailability	bioavailability	NOUN
eurjchem-2534	264	50	and	and	CCONJ
eurjchem-2534	264	51	poor	poor	ADJ
eurjchem-2534	264	52	water	water	NOUN
eurjchem-2534	264	53	solubility	solubility	NOUN
eurjchem-2534	264	54	can	can	AUX
eurjchem-2534	264	55	limit	limit	VERB
eurjchem-2534	264	56	its	its	PRON
eurjchem-2534	264	57	therapeutic	therapeutic	ADJ
eurjchem-2534	264	58	efficacy	efficacy	NOUN
eurjchem-2534	264	59	,	,	PUNCT
eurjchem-2534	264	60	necessitating	necessitate	VERB
eurjchem-2534	264	61	novel	novel	ADJ
eurjchem-2534	264	62	delivery	delivery	NOUN
eurjchem-2534	264	63	systems	system	NOUN
eurjchem-2534	264	64	and	and	CCONJ
eurjchem-2534	264	65	(	(	PUNCT
eurjchem-2534	264	66	iii	iii	NOUN
eurjchem-2534	264	67	)	)	PUNCT
eurjchem-2534	264	68	dosing	dosing	NOUN
eurjchem-2534	264	69	and	and	CCONJ
eurjchem-2534	264	70	administration	administration	NOUN
eurjchem-2534	264	71	:	:	PUNCT
eurjchem-2534	264	72	determining	determine	VERB
eurjchem-2534	264	73	the	the	DET
eurjchem-2534	264	74	optimal	optimal	ADJ
eurjchem-2534	264	75	dose	dose	NOUN
eurjchem-2534	264	76	and	and	CCONJ
eurjchem-2534	264	77	administration	administration	NOUN
eurjchem-2534	264	78	method	method	NOUN
eurjchem-2534	264	79	is	be	AUX
eurjchem-2534	264	80	critical	critical	ADJ
eurjchem-2534	264	81	to	to	PART
eurjchem-2534	264	82	minimize	minimize	VERB
eurjchem-2534	264	83	adverse	adverse	ADJ
eurjchem-2534	264	84	effects	effect	NOUN
eurjchem-2534	264	85	while	while	SCONJ
eurjchem-2534	264	86	maximizing	maximize	VERB
eurjchem-2534	264	87	therapeutic	therapeutic	ADJ
eurjchem-2534	264	88	results	result	NOUN
eurjchem-2534	264	89	.	.	PUNCT
eurjchem-2534	265	1	to	to	PART
eurjchem-2534	265	2	overcome	overcome	VERB
eurjchem-2534	265	3	these	these	DET
eurjchem-2534	265	4	challenges	challenge	NOUN
eurjchem-2534	265	5	,	,	PUNCT
eurjchem-2534	265	6	clinical	clinical	ADJ
eurjchem-2534	265	7	trials	trial	NOUN
eurjchem-2534	265	8	often	often	ADV
eurjchem-2534	265	9	explore	explore	VERB
eurjchem-2534	265	10	advanced	advanced	ADJ
eurjchem-2534	265	11	drug	drug	NOUN
eurjchem-2534	265	12	delivery	delivery	NOUN
eurjchem-2534	265	13	systems	system	NOUN
eurjchem-2534	265	14	such	such	ADJ
eurjchem-2534	265	15	as	as	ADP
eurjchem-2534	265	16	liposomes	liposome	NOUN
eurjchem-2534	265	17	,	,	PUNCT
eurjchem-2534	265	18	nanoparticles	nanoparticle	NOUN
eurjchem-2534	265	19	,	,	PUNCT
eurjchem-2534	265	20	and	and	CCONJ
eurjchem-2534	265	21	other	other	ADJ
eurjchem-2534	265	22	targeted	target	VERB
eurjchem-2534	265	23	delivery	delivery	NOUN
eurjchem-2534	265	24	methods	method	NOUN
eurjchem-2534	265	25	.	.	PUNCT
eurjchem-2534	266	1	these	these	DET
eurjchem-2534	266	2	systems	system	NOUN
eurjchem-2534	266	3	aim	aim	VERB
eurjchem-2534	266	4	to	to	PART
eurjchem-2534	266	5	improve	improve	VERB
eurjchem-2534	266	6	celastrol	celastrol	PROPN
eurjchem-2534	266	7	’s	’s	PART
eurjchem-2534	266	8	bioavailability	bioavailability	NOUN
eurjchem-2534	266	9	,	,	PUNCT
eurjchem-2534	266	10	stability	stability	NOUN
eurjchem-2534	266	11	,	,	PUNCT
eurjchem-2534	266	12	and	and	CCONJ
eurjchem-2534	266	13	targeted	target	VERB
eurjchem-2534	266	14	delivery	delivery	NOUN
eurjchem-2534	266	15	,	,	PUNCT
eurjchem-2534	266	16	thus	thus	ADV
eurjchem-2534	266	17	reducing	reduce	VERB
eurjchem-2534	266	18	side	side	NOUN
eurjchem-2534	266	19	effects	effect	NOUN
eurjchem-2534	266	20	and	and	CCONJ
eurjchem-2534	266	21	enhancing	enhance	VERB
eurjchem-2534	266	22	therapeutic	therapeutic	ADJ
eurjchem-2534	266	23	outcomes	outcome	NOUN
eurjchem-2534	266	24	.	.	PUNCT
eurjchem-2534	267	1	clinical	clinical	ADJ
eurjchem-2534	267	2	trials	trial	NOUN
eurjchem-2534	267	3	with	with	ADP
eurjchem-2534	267	4	celastrol	celastrol	NOUN
eurjchem-2534	267	5	hold	hold	NOUN
eurjchem-2534	267	6	promise	promise	NOUN
eurjchem-2534	267	7	,	,	PUNCT
eurjchem-2534	267	8	but	but	CCONJ
eurjchem-2534	267	9	require	require	VERB
eurjchem-2534	267	10	a	a	DET
eurjchem-2534	267	11	cautious	cautious	ADJ
eurjchem-2534	267	12	approach	approach	NOUN
eurjchem-2534	267	13	to	to	PART
eurjchem-2534	267	14	ensure	ensure	VERB
eurjchem-2534	267	15	safety	safety	NOUN
eurjchem-2534	267	16	and	and	CCONJ
eurjchem-2534	267	17	efficacy	efficacy	NOUN
eurjchem-2534	267	18	.	.	PUNCT
eurjchem-2534	268	1	as	as	SCONJ
eurjchem-2534	268	2	research	research	NOUN
eurjchem-2534	268	3	progresses	progress	NOUN
eurjchem-2534	268	4	,	,	PUNCT
eurjchem-2534	268	5	these	these	DET
eurjchem-2534	268	6	trials	trial	NOUN
eurjchem-2534	268	7	will	will	AUX
eurjchem-2534	268	8	provide	provide	VERB
eurjchem-2534	268	9	valuable	valuable	ADJ
eurjchem-2534	268	10	insights	insight	NOUN
eurjchem-2534	268	11	into	into	ADP
eurjchem-2534	268	12	how	how	SCONJ
eurjchem-2534	268	13	celastrol	celastrol	NOUN
eurjchem-2534	268	14	can	can	AUX
eurjchem-2534	268	15	be	be	AUX
eurjchem-2534	268	16	used	use	VERB
eurjchem-2534	268	17	effectively	effectively	ADV
eurjchem-2534	268	18	in	in	ADP
eurjchem-2534	268	19	clinical	clinical	ADJ
eurjchem-2534	268	20	settings	setting	NOUN
eurjchem-2534	268	21	,	,	PUNCT
eurjchem-2534	268	22	potentially	potentially	ADV
eurjchem-2534	268	23	offering	offer	VERB
eurjchem-2534	268	24	new	new	ADJ
eurjchem-2534	268	25	treatment	treatment	NOUN
eurjchem-2534	268	26	options	option	NOUN
eurjchem-2534	268	27	for	for	ADP
eurjchem-2534	268	28	a	a	DET
eurjchem-2534	268	29	variety	variety	NOUN
eurjchem-2534	268	30	of	of	ADP
eurjchem-2534	268	31	diseases	disease	NOUN
eurjchem-2534	268	32	.	.	PUNCT
eurjchem-2534	269	1	5	5	X
eurjchem-2534	269	2	.	.	X
eurjchem-2534	269	3	conclusions	conclusion	NOUN
eurjchem-2534	269	4	celastrol	celastrol	PROPN
eurjchem-2534	269	5	,	,	PUNCT
eurjchem-2534	269	6	a	a	DET
eurjchem-2534	269	7	key	key	ADJ
eurjchem-2534	269	8	compound	compound	NOUN
eurjchem-2534	269	9	derived	derive	VERB
eurjchem-2534	269	10	from	from	ADP
eurjchem-2534	269	11	tripterygium	tripterygium	NOUN
eurjchem-2534	269	12	wilfordii	wilfordii	NOUN
eurjchem-2534	269	13	hook	hook	NOUN
eurjchem-2534	269	14	f.	f.	PROPN
eurjchem-2534	269	15	,	,	PUNCT
eurjchem-2534	269	16	emerges	emerge	VERB
eurjchem-2534	269	17	as	as	ADP
eurjchem-2534	269	18	a	a	DET
eurjchem-2534	269	19	promising	promising	ADJ
eurjchem-2534	269	20	natural	natural	ADJ
eurjchem-2534	269	21	product	product	NOUN
eurjchem-2534	269	22	with	with	ADP
eurjchem-2534	269	23	a	a	DET
eurjchem-2534	269	24	diverse	diverse	ADJ
eurjchem-2534	269	25	range	range	NOUN
eurjchem-2534	269	26	of	of	ADP
eurjchem-2534	269	27	pharmacological	pharmacological	ADJ
eurjchem-2534	269	28	properties	property	NOUN
eurjchem-2534	269	29	.	.	PUNCT
eurjchem-2534	270	1	its	its	PRON
eurjchem-2534	270	2	potential	potential	ADJ
eurjchem-2534	270	3	therapeutic	therapeutic	ADJ
eurjchem-2534	270	4	applications	application	NOUN
eurjchem-2534	270	5	extend	extend	VERB
eurjchem-2534	270	6	across	across	ADP
eurjchem-2534	270	7	various	various	ADJ
eurjchem-2534	270	8	health	health	NOUN
eurjchem-2534	270	9	domains	domain	NOUN
eurjchem-2534	270	10	,	,	PUNCT
eurjchem-2534	270	11	including	include	VERB
eurjchem-2534	270	12	anti	anti	ADJ
eurjchem-2534	270	13	-	-	ADJ
eurjchem-2534	270	14	inflammatory	inflammatory	ADJ
eurjchem-2534	270	15	,	,	PUNCT
eurjchem-2534	270	16	anticancer	anticancer	NOUN
eurjchem-2534	270	17	,	,	PUNCT
eurjchem-2534	270	18	neuroprotective	neuroprotective	NOUN
eurjchem-2534	270	19	,	,	PUNCT
eurjchem-2534	270	20	and	and	CCONJ
eurjchem-2534	270	21	cardioprotective	cardioprotective	ADJ
eurjchem-2534	270	22	effects	effect	NOUN
eurjchem-2534	270	23	.	.	PUNCT
eurjchem-2534	271	1	however	however	ADV
eurjchem-2534	271	2	,	,	PUNCT
eurjchem-2534	271	3	despite	despite	SCONJ
eurjchem-2534	271	4	its	its	PRON
eurjchem-2534	271	5	promise	promise	NOUN
eurjchem-2534	271	6	,	,	PUNCT
eurjchem-2534	271	7	several	several	ADJ
eurjchem-2534	271	8	challenges	challenge	NOUN
eurjchem-2534	271	9	remain	remain	VERB
eurjchem-2534	271	10	,	,	PUNCT
eurjchem-2534	271	11	particularly	particularly	ADV
eurjchem-2534	271	12	regarding	regard	VERB
eurjchem-2534	271	13	celastrol	celastrol	NOUN
eurjchem-2534	271	14	’s	’s	PART
eurjchem-2534	271	15	high	high	ADJ
eurjchem-2534	271	16	toxicity	toxicity	NOUN
eurjchem-2534	271	17	,	,	PUNCT
eurjchem-2534	271	18	low	low	ADJ
eurjchem-2534	271	19	water	water	NOUN
eurjchem-2534	271	20	solubility	solubility	NOUN
eurjchem-2534	271	21	,	,	PUNCT
eurjchem-2534	271	22	and	and	CCONJ
eurjchem-2534	271	23	limited	limited	ADJ
eurjchem-2534	271	24	stability	stability	NOUN
eurjchem-2534	271	25	,	,	PUNCT
eurjchem-2534	271	26	which	which	PRON
eurjchem-2534	271	27	can	can	AUX
eurjchem-2534	271	28	hinder	hinder	VERB
eurjchem-2534	271	29	its	its	PRON
eurjchem-2534	271	30	widespread	widespread	ADJ
eurjchem-2534	271	31	clinical	clinical	ADJ
eurjchem-2534	271	32	use	use	NOUN
eurjchem-2534	271	33	.	.	PUNCT
eurjchem-2534	272	1	to	to	ADP
eurjchem-2534	272	2	fully	fully	ADV
eurjchem-2534	272	3	harness	harness	ADJ
eurjchem-2534	272	4	celastrol	celastrol	NOUN
eurjchem-2534	272	5	’s	’s	PART
eurjchem-2534	272	6	therapeutic	therapeutic	ADJ
eurjchem-2534	272	7	potential	potential	NOUN
eurjchem-2534	272	8	,	,	PUNCT
eurjchem-2534	272	9	ongoing	ongoing	ADJ
eurjchem-2534	272	10	research	research	NOUN
eurjchem-2534	272	11	must	must	AUX
eurjchem-2534	272	12	address	address	VERB
eurjchem-2534	272	13	these	these	DET
eurjchem-2534	272	14	challenges	challenge	NOUN
eurjchem-2534	272	15	through	through	ADP
eurjchem-2534	272	16	innovative	innovative	ADJ
eurjchem-2534	272	17	drug	drug	NOUN
eurjchem-2534	272	18	delivery	delivery	NOUN
eurjchem-2534	272	19	systems	system	NOUN
eurjchem-2534	272	20	and	and	CCONJ
eurjchem-2534	272	21	chemical	chemical	NOUN
eurjchem-2534	272	22	modifications	modification	NOUN
eurjchem-2534	272	23	that	that	PRON
eurjchem-2534	272	24	improve	improve	VERB
eurjchem-2534	272	25	bioavailability	bioavailability	NOUN
eurjchem-2534	272	26	and	and	CCONJ
eurjchem-2534	272	27	reduce	reduce	VERB
eurjchem-2534	272	28	toxicity	toxicity	NOUN
eurjchem-2534	272	29	.	.	PUNCT
eurjchem-2534	273	1	current	current	ADJ
eurjchem-2534	273	2	studies	study	NOUN
eurjchem-2534	273	3	have	have	AUX
eurjchem-2534	273	4	demonstrated	demonstrate	VERB
eurjchem-2534	273	5	promising	promising	ADJ
eurjchem-2534	273	6	approaches	approach	NOUN
eurjchem-2534	273	7	,	,	PUNCT
eurjchem-2534	273	8	such	such	ADJ
eurjchem-2534	273	9	as	as	ADP
eurjchem-2534	273	10	direct	direct	ADJ
eurjchem-2534	273	11	modifications	modification	NOUN
eurjchem-2534	273	12	to	to	ADP
eurjchem-2534	273	13	the	the	DET
eurjchem-2534	273	14	celastrol	celastrol	NOUN
eurjchem-2534	273	15	molecule	molecule	NOUN
eurjchem-2534	273	16	,	,	PUNCT
eurjchem-2534	273	17	including	include	VERB
eurjchem-2534	273	18	pegylation	pegylation	NOUN
eurjchem-2534	273	19	and	and	CCONJ
eurjchem-2534	273	20	fatty	fatty	NOUN
eurjchem-2534	273	21	acid	acid	NOUN
eurjchem-2534	273	22	conjugation	conjugation	NOUN
eurjchem-2534	273	23	,	,	PUNCT
eurjchem-2534	273	24	as	as	ADV
eurjchem-2534	273	25	well	well	ADV
eurjchem-2534	273	26	as	as	ADP
eurjchem-2534	273	27	indirect	indirect	ADJ
eurjchem-2534	273	28	modifications	modification	NOUN
eurjchem-2534	273	29	through	through	ADP
eurjchem-2534	273	30	encapsulation	encapsulation	NOUN
eurjchem-2534	273	31	in	in	ADP
eurjchem-2534	273	32	nanocarriers	nanocarrier	NOUN
eurjchem-2534	273	33	,	,	PUNCT
eurjchem-2534	273	34	liposomes	liposome	NOUN
eurjchem-2534	273	35	,	,	PUNCT
eurjchem-2534	273	36	and	and	CCONJ
eurjchem-2534	273	37	dendritic	dendritic	ADJ
eurjchem-2534	273	38	polymers	polymer	NOUN
eurjchem-2534	273	39	.	.	PUNCT
eurjchem-2534	274	1	these	these	DET
eurjchem-2534	274	2	developments	development	NOUN
eurjchem-2534	274	3	are	be	AUX
eurjchem-2534	274	4	crucial	crucial	ADJ
eurjchem-2534	274	5	for	for	ADP
eurjchem-2534	274	6	advancing	advance	VERB
eurjchem-2534	274	7	celastrol	celastrol	NOUN
eurjchem-2534	274	8	from	from	ADP
eurjchem-2534	274	9	a	a	DET
eurjchem-2534	274	10	promising	promising	ADJ
eurjchem-2534	274	11	natural	natural	ADJ
eurjchem-2534	274	12	compound	compound	NOUN
eurjchem-2534	274	13	to	to	ADP
eurjchem-2534	274	14	a	a	DET
eurjchem-2534	274	15	practical	practical	ADJ
eurjchem-2534	274	16	and	and	CCONJ
eurjchem-2534	274	17	effective	effective	ADJ
eurjchem-2534	274	18	therapeutic	therapeutic	ADJ
eurjchem-2534	274	19	agent	agent	NOUN
eurjchem-2534	274	20	in	in	ADP
eurjchem-2534	274	21	clinical	clinical	ADJ
eurjchem-2534	274	22	settings	setting	NOUN
eurjchem-2534	274	23	.	.	PUNCT
eurjchem-2534	275	1	given	give	VERB
eurjchem-2534	275	2	its	its	PRON
eurjchem-2534	275	3	broad	broad	ADJ
eurjchem-2534	275	4	therapeutic	therapeutic	ADJ
eurjchem-2534	275	5	scope	scope	NOUN
eurjchem-2534	275	6	,	,	PUNCT
eurjchem-2534	275	7	celastrol	celastrol	NOUN
eurjchem-2534	275	8	represents	represent	VERB
eurjchem-2534	275	9	a	a	DET
eurjchem-2534	275	10	compelling	compelling	ADJ
eurjchem-2534	275	11	target	target	NOUN
eurjchem-2534	275	12	for	for	ADP
eurjchem-2534	275	13	future	future	ADJ
eurjchem-2534	275	14	drug	drug	NOUN
eurjchem-2534	275	15	discovery	discovery	NOUN
eurjchem-2534	275	16	and	and	CCONJ
eurjchem-2534	275	17	development	development	NOUN
eurjchem-2534	275	18	.	.	PUNCT
eurjchem-2534	276	1	further	further	ADJ
eurjchem-2534	276	2	investigation	investigation	NOUN
eurjchem-2534	276	3	is	be	AUX
eurjchem-2534	276	4	required	require	VERB
eurjchem-2534	276	5	to	to	PART
eurjchem-2534	276	6	refine	refine	VERB
eurjchem-2534	276	7	its	its	PRON
eurjchem-2534	276	8	pharmacokinetic	pharmacokinetic	ADJ
eurjchem-2534	276	9	profile	profile	NOUN
eurjchem-2534	276	10	and	and	CCONJ
eurjchem-2534	276	11	explore	explore	VERB
eurjchem-2534	276	12	its	its	PRON
eurjchem-2534	276	13	applications	application	NOUN
eurjchem-2534	276	14	in	in	ADP
eurjchem-2534	276	15	the	the	DET
eurjchem-2534	276	16	treatment	treatment	NOUN
eurjchem-2534	276	17	of	of	ADP
eurjchem-2534	276	18	various	various	ADJ
eurjchem-2534	276	19	diseases	disease	NOUN
eurjchem-2534	276	20	.	.	PUNCT
eurjchem-2534	277	1	this	this	DET
eurjchem-2534	277	2	exploration	exploration	NOUN
eurjchem-2534	277	3	has	have	VERB
eurjchem-2534	277	4	significant	significant	ADJ
eurjchem-2534	277	5	potential	potential	NOUN
eurjchem-2534	277	6	to	to	PART
eurjchem-2534	277	7	develop	develop	VERB
eurjchem-2534	277	8	novel	novel	ADJ
eurjchem-2534	277	9	treatments	treatment	NOUN
eurjchem-2534	277	10	that	that	PRON
eurjchem-2534	277	11	incorporate	incorporate	VERB
eurjchem-2534	277	12	traditional	traditional	ADJ
eurjchem-2534	277	13	wisdom	wisdom	NOUN
eurjchem-2534	277	14	with	with	ADP
eurjchem-2534	277	15	modern	modern	ADJ
eurjchem-2534	277	16	pharmacology	pharmacology	NOUN
eurjchem-2534	277	17	,	,	PUNCT
eurjchem-2534	277	18	ultimately	ultimately	ADV
eurjchem-2534	277	19	contributing	contribute	VERB
eurjchem-2534	277	20	to	to	ADP
eurjchem-2534	277	21	improved	improve	VERB
eurjchem-2534	277	22	patient	patient	ADJ
eurjchem-2534	277	23	outcomes	outcome	NOUN
eurjchem-2534	277	24	and	and	CCONJ
eurjchem-2534	277	25	advancing	advance	VERB
eurjchem-2534	277	26	the	the	DET
eurjchem-2534	277	27	field	field	NOUN
eurjchem-2534	277	28	of	of	ADP
eurjchem-2534	277	29	medicine	medicine	NOUN
eurjchem-2534	277	30	.	.	PUNCT
eurjchem-2534	278	1	acknowledgements	acknowledgement	NOUN
eurjchem-2534	278	2	this	this	DET
eurjchem-2534	278	3	research	research	NOUN
eurjchem-2534	278	4	was	be	AUX
eurjchem-2534	278	5	supported	support	VERB
eurjchem-2534	278	6	by	by	ADP
eurjchem-2534	278	7	science	science	NOUN
eurjchem-2534	278	8	and	and	CCONJ
eurjchem-2534	278	9	technology	technology	NOUN
eurjchem-2534	278	10	development	development	NOUN
eurjchem-2534	278	11	fund	fund	PROPN
eurjchem-2534	278	12	fdct	fdct	NOUN
eurjchem-2534	278	13	grants	grant	NOUN
eurjchem-2534	278	14	from	from	ADP
eurjchem-2534	278	15	macau	macau	PROPN
eurjchem-2534	278	16	university	university	PROPN
eurjchem-2534	278	17	of	of	ADP
eurjchem-2534	278	18	science	science	NOUN
eurjchem-2534	278	19	and	and	CCONJ
eurjchem-2534	278	20	technology	technology	NOUN
eurjchem-2534	278	21	to	to	ADP
eurjchem-2534	278	22	pc	pc	NOUN
eurjchem-2534	278	23	(	(	PUNCT
eurjchem-2534	278	24	project	project	NOUN
eurjchem-2534	278	25	code	code	NOUN
eurjchem-2534	278	26	:	:	PUNCT
eurjchem-2534	278	27	0005	0005	NUM
eurjchem-2534	278	28	-	-	PUNCT
eurjchem-2534	278	29	2023	2023	NUM
eurjchem-2534	278	30	-	-	PUNCT
eurjchem-2534	278	31	ria1	ria1	NOUN
eurjchem-2534	278	32	)	)	PUNCT
eurjchem-2534	278	33	.	.	PUNCT
eurjchem-2534	279	1	abbreviations	abbreviation	NOUN
eurjchem-2534	279	2	serca	serca	NOUN
eurjchem-2534	279	3	=	=	SYM
eurjchem-2534	279	4	sarco	sarco	PROPN
eurjchem-2534	279	5	-	-	PUNCT
eurjchem-2534	279	6	endoplasmic	endoplasmic	ADJ
eurjchem-2534	279	7	reticulum	reticulum	NOUN
eurjchem-2534	279	8	calcium	calcium	NOUN
eurjchem-2534	279	9	atpase	atpase	NOUN
eurjchem-2534	279	10	;	;	PUNCT
eurjchem-2534	279	11	hsp90	hsp90	ADJ
eurjchem-2534	279	12	-	-	PUNCT
eurjchem-2534	279	13	cdc37	cdc37	NOUN
eurjchem-2534	279	14	=	=	NOUN
eurjchem-2534	279	15	heat	heat	NOUN
eurjchem-2534	279	16	shock	shock	NOUN
eurjchem-2534	279	17	protein	protein	NOUN
eurjchem-2534	279	18	90	90	NUM
eurjchem-2534	279	19	(	(	PUNCT
eurjchem-2534	279	20	cell	cell	NOUN
eurjchem-2534	279	21	division	division	NOUN
eurjchem-2534	279	22	cycle	cycle	NOUN
eurjchem-2534	279	23	37	37	NUM
eurjchem-2534	279	24	)	)	PUNCT
eurjchem-2534	279	25	;	;	PUNCT
eurjchem-2534	279	26	nf	nf	X
eurjchem-2534	279	27	-	-	PUNCT
eurjchem-2534	279	28	kb	kb	NOUN
eurjchem-2534	279	29	/	/	SYM
eurjchem-2534	279	30	ikkb	ikkb	NOUN
eurjchem-2534	279	31	=	=	NOUN
eurjchem-2534	279	32	nuclear	nuclear	ADJ
eurjchem-2534	279	33	factor	factor	NOUN
eurjchem-2534	279	34	kappa	kappa	ADJ
eurjchem-2534	279	35	-	-	ADJ
eurjchem-2534	279	36	light	light	ADJ
eurjchem-2534	279	37	-	-	PUNCT
eurjchem-2534	279	38	chain	chain	NOUN
eurjchem-2534	279	39	-	-	PUNCT
eurjchem-2534	279	40	enhancer	enhancer	NOUN
eurjchem-2534	279	41	of	of	ADP
eurjchem-2534	279	42	activated	activate	VERB
eurjchem-2534	279	43	b	b	PROPN
eurjchem-2534	279	44	cells	cell	NOUN
eurjchem-2534	279	45	inhibitor	inhibitor	NOUN
eurjchem-2534	279	46	of	of	ADP
eurjchem-2534	279	47	the	the	DET
eurjchem-2534	279	48	nuclear	nuclear	ADJ
eurjchem-2534	279	49	factor	factor	NOUN
eurjchem-2534	279	50	kappa	kappa	PROPN
eurjchem-2534	279	51	-	-	PROPN
eurjchem-2534	279	52	b	b	PROPN
eurjchem-2534	279	53	kinase	kinase	PROPN
eurjchem-2534	279	54	subunit	subunit	NOUN
eurjchem-2534	279	55	beta	beta	NOUN
eurjchem-2534	279	56	;	;	PUNCT
eurjchem-2534	279	57	vegfr1	vegfr1	NOUN
eurjchem-2534	279	58	=	=	SYM
eurjchem-2534	279	59	vascular	vascular	ADJ
eurjchem-2534	279	60	endothelial	endothelial	ADJ
eurjchem-2534	279	61	growth	growth	NOUN
eurjchem-2534	279	62	factor	factor	NOUN
eurjchem-2534	279	63	receptor	receptor	NOUN
eurjchem-2534	279	64	1	1	NUM
eurjchem-2534	279	65	;	;	PUNCT
eurjchem-2534	279	66	pi3k	pi3k	PROPN
eurjchem-2534	279	67	/	/	SYM
eurjchem-2534	279	68	akt	akt	PROPN
eurjchem-2534	279	69	=	=	NOUN
eurjchem-2534	279	70	phosphoinositide	phosphoinositide	PROPN
eurjchem-2534	279	71	3	3	NUM
eurjchem-2534	279	72	-	-	PUNCT
eurjchem-2534	279	73	kinase	kinase	NOUN
eurjchem-2534	279	74	(	(	PUNCT
eurjchem-2534	279	75	pi3k	pi3k	PROPN
eurjchem-2534	279	76	)	)	PUNCT
eurjchem-2534	279	77	and	and	CCONJ
eurjchem-2534	280	1	protein	protein	NOUN
eurjchem-2534	280	2	kinase	kinase	PROPN
eurjchem-2534	280	3	b	b	PROPN
eurjchem-2534	280	4	(	(	PUNCT
eurjchem-2534	280	5	akt	akt	PROPN
eurjchem-2534	280	6	)	)	PUNCT
eurjchem-2534	280	7	.	.	PUNCT
eurjchem-2534	281	1	disclosure	disclosure	NOUN
eurjchem-2534	281	2	statement	statement	NOUN
eurjchem-2534	281	3	conflict	conflict	NOUN
eurjchem-2534	281	4	of	of	ADP
eurjchem-2534	281	5	interest	interest	NOUN
eurjchem-2534	281	6	:	:	PUNCT
eurjchem-2534	281	7	the	the	DET
eurjchem-2534	281	8	authors	author	NOUN
eurjchem-2534	281	9	declare	declare	VERB
eurjchem-2534	281	10	that	that	SCONJ
eurjchem-2534	281	11	they	they	PRON
eurjchem-2534	281	12	have	have	VERB
eurjchem-2534	281	13	no	no	DET
eurjchem-2534	281	14	conflict	conflict	NOUN
eurjchem-2534	281	15	of	of	ADP
eurjchem-2534	281	16	interest	interest	NOUN
eurjchem-2534	281	17	.	.	PUNCT
eurjchem-2534	282	1	ren	ren	NOUN
eurjchem-2534	282	2	and	and	CCONJ
eurjchem-2534	282	3	coghi	coghi	PROPN
eurjchem-2534	282	4	/	/	SYM
eurjchem-2534	282	5	european	european	PROPN
eurjchem-2534	282	6	journal	journal	PROPN
eurjchem-2534	282	7	of	of	ADP
eurjchem-2534	282	8	chemistry	chemistry	NOUN
eurjchem-2534	282	9	15	15	NUM
eurjchem-2534	282	10	(	(	PUNCT
eurjchem-2534	282	11	2	2	NUM
eurjchem-2534	282	12	)	)	PUNCT
eurjchem-2534	282	13	(	(	PUNCT
eurjchem-2534	282	14	2024	2024	NUM
eurjchem-2534	282	15	)	)	PUNCT
eurjchem-2534	282	16	194	194	NUM
eurjchem-2534	282	17	-	-	SYM
eurjchem-2534	282	18	204	204	NUM
eurjchem-2534	282	19	203	203	NUM
eurjchem-2534	282	20	2024	2024	NUM
eurjchem-2534	282	21	–	–	PUNCT
eurjchem-2534	282	22	european	european	ADJ
eurjchem-2534	282	23	journal	journal	NOUN
eurjchem-2534	282	24	of	of	ADP
eurjchem-2534	282	25	chemistry	chemistry	NOUN
eurjchem-2534	282	26	–	–	PUNCT
eurjchem-2534	282	27	cc	cc	NOUN
eurjchem-2534	282	28	by	by	ADP
eurjchem-2534	282	29	nc	nc	PROPN
eurjchem-2534	282	30	–	–	PUNCT
eurjchem-2534	282	31	doi	doi	PROPN
eurjchem-2534	282	32	:	:	PUNCT
eurjchem-2534	282	33	10.5155	10.5155	NUM
eurjchem-2534	282	34	/	/	SYM
eurjchem-2534	282	35	eurjchem.15.2.194	eurjchem.15.2.194	NUM
eurjchem-2534	282	36	-	-	PUNCT
eurjchem-2534	282	37	204.2534	204.2534	NUM
eurjchem-2534	282	38	credit	credit	NOUN
eurjchem-2534	282	39	authorship	authorship	NOUN
eurjchem-2534	282	40	contribution	contribution	NOUN
eurjchem-2534	282	41	statement	statement	NOUN
eurjchem-2534	282	42	conceptualization	conceptualization	NOUN
eurjchem-2534	282	43	:	:	PUNCT
eurjchem-2534	282	44	paolo	paolo	PROPN
eurjchem-2534	282	45	coghi	coghi	PROPN
eurjchem-2534	282	46	;	;	PUNCT
eurjchem-2534	282	47	methodology	methodology	NOUN
eurjchem-2534	282	48	:	:	PUNCT
eurjchem-2534	282	49	zimo	zimo	PROPN
eurjchem-2534	282	50	ren	ren	PROPN
eurjchem-2534	282	51	;	;	PUNCT
eurjchem-2534	282	52	software	software	NOUN
eurjchem-2534	282	53	:	:	PUNCT
eurjchem-2534	282	54	zimo	zimo	PROPN
eurjchem-2534	282	55	ren	ren	PROPN
eurjchem-2534	282	56	;	;	PUNCT
eurjchem-2534	282	57	validation	validation	NOUN
eurjchem-2534	282	58	:	:	PUNCT
eurjchem-2534	282	59	zimo	zimo	PROPN
eurjchem-2534	282	60	ren	ren	PROPN
eurjchem-2534	282	61	;	;	PUNCT
eurjchem-2534	282	62	formal	formal	ADJ
eurjchem-2534	282	63	analysis	analysis	NOUN
eurjchem-2534	282	64	:	:	PUNCT
eurjchem-2534	282	65	zimo	zimo	PROPN
eurjchem-2534	282	66	ren	ren	PROPN
eurjchem-2534	282	67	;	;	PUNCT
eurjchem-2534	282	68	resources	resource	NOUN
eurjchem-2534	282	69	:	:	PUNCT
eurjchem-2534	282	70	zimo	zimo	PROPN
eurjchem-2534	282	71	ren	ren	PROPN
eurjchem-2534	282	72	;	;	PUNCT
eurjchem-2534	282	73	data	datum	NOUN
eurjchem-2534	282	74	curation	curation	NOUN
eurjchem-2534	282	75	:	:	PUNCT
eurjchem-2534	282	76	zimo	zimo	PROPN
eurjchem-2534	282	77	ren	ren	PROPN
eurjchem-2534	282	78	;	;	PUNCT
eurjchem-2534	282	79	writing	write	VERB
eurjchem-2534	282	80	original	original	ADJ
eurjchem-2534	282	81	draft	draft	NOUN
eurjchem-2534	282	82	:	:	PUNCT
eurjchem-2534	282	83	zimo	zimo	PROPN
eurjchem-2534	282	84	ren	ren	PROPN
eurjchem-2534	282	85	;	;	PUNCT
eurjchem-2534	282	86	writing	write	VERB
eurjchem-2534	282	87	review	review	NOUN
eurjchem-2534	282	88	and	and	CCONJ
eurjchem-2534	282	89	editing	editing	NOUN
eurjchem-2534	282	90	:	:	PUNCT
eurjchem-2534	282	91	zimo	zimo	PROPN
eurjchem-2534	282	92	ren	ren	PROPN
eurjchem-2534	282	93	,	,	PUNCT
eurjchem-2534	282	94	paolo	paolo	PROPN
eurjchem-2534	282	95	coghi	coghi	PROPN
eurjchem-2534	282	96	;	;	PUNCT
eurjchem-2534	282	97	visualization	visualization	NOUN
eurjchem-2534	282	98	:	:	PUNCT
eurjchem-2534	282	99	paolo	paolo	PROPN
eurjchem-2534	282	100	coghi	coghi	PROPN
eurjchem-2534	282	101	;	;	PUNCT
eurjchem-2534	282	102	funding	funding	NOUN
eurjchem-2534	282	103	acquisition	acquisition	NOUN
eurjchem-2534	282	104	:	:	PUNCT
eurjchem-2534	282	105	paolo	paolo	PROPN
eurjchem-2534	282	106	coghi	coghi	PROPN
eurjchem-2534	282	107	;	;	PUNCT
eurjchem-2534	282	108	supervision	supervision	NOUN
eurjchem-2534	282	109	:	:	PUNCT
eurjchem-2534	282	110	paolo	paolo	PROPN
eurjchem-2534	282	111	coghi	coghi	PROPN
eurjchem-2534	282	112	;	;	PUNCT
eurjchem-2534	282	113	project	project	NOUN
eurjchem-2534	282	114	administration	administration	NOUN
eurjchem-2534	282	115	:	:	PUNCT
eurjchem-2534	282	116	paolo	paolo	PROPN
eurjchem-2534	282	117	coghi	coghi	PROPN
eurjchem-2534	282	118	.	.	PUNCT
eurjchem-2534	283	1	funding	funding	NOUN
eurjchem-2534	283	2	science	science	NOUN
eurjchem-2534	283	3	and	and	CCONJ
eurjchem-2534	283	4	technology	technology	NOUN
eurjchem-2534	283	5	development	development	NOUN
eurjchem-2534	283	6	fund	fund	PROPN
eurjchem-2534	283	7	https://www.fdct.gov.mo/en	https://www.fdct.gov.mo/en	ADJ
eurjchem-2534	283	8	orcid	orcid	NOUN
eurjchem-2534	283	9	and	and	CCONJ
eurjchem-2534	283	10	email	email	NOUN
eurjchem-2534	284	1	zimo	zimo	PROPN
eurjchem-2534	284	2	ren	ren	PROPN
eurjchem-2534	284	3	2230028575@student.must.edu.mo	2230028575@student.must.edu.mo	PROPN
eurjchem-2534	284	4	https://orcid.org/0009-0007-2534-444x	https://orcid.org/0009-0007-2534-444x	PROPN
eurjchem-2534	284	5	paolo	paolo	PROPN
eurjchem-2534	284	6	coghi	coghi	PROPN
eurjchem-2534	284	7	coghips@must.edu.mo	coghips@must.edu.mo	PROPN
eurjchem-2534	284	8	https://orcid.org/0000-0002-0015-1453	https://orcid.org/0000-0002-0015-1453	NOUN
eurjchem-2534	284	9	references	reference	NOUN
eurjchem-2534	284	10	[	[	X
eurjchem-2534	284	11	1	1	NUM
eurjchem-2534	284	12	]	]	PUNCT
eurjchem-2534	284	13	.	.	PUNCT
eurjchem-2534	285	1	the	the	DET
eurjchem-2534	285	2	encyclopedia	encyclopedia	NOUN
eurjchem-2534	285	3	of	of	ADP
eurjchem-2534	285	4	traditional	traditional	ADJ
eurjchem-2534	285	5	chinese	chinese	ADJ
eurjchem-2534	285	6	medicine	medicine	NOUN
eurjchem-2534	285	7	2.0	2.0	NUM
eurjchem-2534	285	8	etcm2.0	etcm2.0	PROPN
eurjchem-2534	285	9	.	.	PUNCT
eurjchem-2534	286	1	http://www.tcmip.cn/etcm2/front/#/	http://www.tcmip.cn/etcm2/front/#/	PROPN
eurjchem-2534	286	2	(	(	PUNCT
eurjchem-2534	286	3	accessed	access	VERB
eurjchem-2534	286	4	jan	jan	PROPN
eurjchem-2534	286	5	11	11	NUM
eurjchem-2534	286	6	,	,	PUNCT
eurjchem-2534	286	7	2024	2024	NUM
eurjchem-2534	286	8	)	)	PUNCT
eurjchem-2534	286	9	.	.	PUNCT
eurjchem-2534	287	1	[	[	X
eurjchem-2534	287	2	2	2	NUM
eurjchem-2534	287	3	]	]	PUNCT
eurjchem-2534	287	4	.	.	PUNCT
eurjchem-2534	288	1	li	li	PROPN
eurjchem-2534	288	2	,	,	PUNCT
eurjchem-2534	288	3	m.	m.	NOUN
eurjchem-2534	288	4	;	;	PUNCT
eurjchem-2534	288	5	liang	liang	PROPN
eurjchem-2534	288	6	,	,	PUNCT
eurjchem-2534	288	7	y.	y.	PROPN
eurjchem-2534	288	8	li	li	PROPN
eurjchem-2534	289	1	shizhen	shizhen	ADV
eurjchem-2534	289	2	and	and	CCONJ
eurjchem-2534	289	3	the	the	DET
eurjchem-2534	289	4	grand	grand	ADJ
eurjchem-2534	289	5	compendium	compendium	NOUN
eurjchem-2534	289	6	of	of	ADP
eurjchem-2534	289	7	materia	materia	PROPN
eurjchem-2534	289	8	medica	medica	PROPN
eurjchem-2534	289	9	.	.	PUNCT
eurjchem-2534	290	1	j.	j.	PROPN
eurjchem-2534	290	2	tradit	tradit	PROPN
eurjchem-2534	290	3	.	.	PUNCT
eurjchem-2534	291	1	chin	chin	PROPN
eurjchem-2534	291	2	.	.	PUNCT
eurjchem-2534	291	3	med	med	PROPN
eurjchem-2534	291	4	.	.	PUNCT
eurjchem-2534	292	1	sci	sci	PROPN
eurjchem-2534	292	2	.	.	PROPN
eurjchem-2534	292	3	2015	2015	NUM
eurjchem-2534	292	4	,	,	PUNCT
eurjchem-2534	292	5	2	2	NUM
eurjchem-2534	292	6	,	,	PUNCT
eurjchem-2534	292	7	215–216	215–216	NUM
eurjchem-2534	292	8	.	.	PUNCT
eurjchem-2534	293	1	[	[	X
eurjchem-2534	293	2	3	3	NUM
eurjchem-2534	293	3	]	]	PUNCT
eurjchem-2534	293	4	.	.	PUNCT
eurjchem-2534	294	1	kannaiyan	kannaiyan	PROPN
eurjchem-2534	294	2	,	,	PUNCT
eurjchem-2534	294	3	r.	r.	PROPN
eurjchem-2534	294	4	;	;	PUNCT
eurjchem-2534	294	5	shanmugam	shanmugam	NOUN
eurjchem-2534	294	6	,	,	PUNCT
eurjchem-2534	294	7	m.	m.	PROPN
eurjchem-2534	294	8	k.	k.	PROPN
eurjchem-2534	294	9	;	;	PUNCT
eurjchem-2534	294	10	sethi	sethi	PROPN
eurjchem-2534	294	11	,	,	PUNCT
eurjchem-2534	294	12	g.	g.	PROPN
eurjchem-2534	294	13	molecular	molecular	ADJ
eurjchem-2534	294	14	targets	target	NOUN
eurjchem-2534	294	15	of	of	ADP
eurjchem-2534	294	16	celastrol	celastrol	NOUN
eurjchem-2534	294	17	derived	derive	VERB
eurjchem-2534	294	18	from	from	ADP
eurjchem-2534	294	19	thunder	thunder	NOUN
eurjchem-2534	294	20	of	of	ADP
eurjchem-2534	294	21	god	god	PROPN
eurjchem-2534	294	22	vine	vine	PROPN
eurjchem-2534	294	23	:	:	PUNCT
eurjchem-2534	294	24	potential	potential	ADJ
eurjchem-2534	294	25	role	role	NOUN
eurjchem-2534	294	26	in	in	ADP
eurjchem-2534	294	27	the	the	DET
eurjchem-2534	294	28	treatment	treatment	NOUN
eurjchem-2534	294	29	of	of	ADP
eurjchem-2534	294	30	inflammatory	inflammatory	ADJ
eurjchem-2534	294	31	disorders	disorder	NOUN
eurjchem-2534	294	32	and	and	CCONJ
eurjchem-2534	294	33	cancer	cancer	NOUN
eurjchem-2534	294	34	.	.	PUNCT
eurjchem-2534	295	1	cancer	cancer	PROPN
eurjchem-2534	295	2	lett	lett	PROPN
eurjchem-2534	295	3	.	.	PUNCT
eurjchem-2534	296	1	2011	2011	NUM
eurjchem-2534	296	2	,	,	PUNCT
eurjchem-2534	296	3	303	303	NUM
eurjchem-2534	296	4	,	,	PUNCT
eurjchem-2534	296	5	9–20	9–20	NOUN
eurjchem-2534	296	6	.	.	PUNCT
eurjchem-2534	297	1	[	[	X
eurjchem-2534	297	2	4	4	NUM
eurjchem-2534	297	3	]	]	PUNCT
eurjchem-2534	297	4	.	.	PUNCT
eurjchem-2534	298	1	allison	allison	PROPN
eurjchem-2534	298	2	,	,	PUNCT
eurjchem-2534	298	3	a.	a.	PROPN
eurjchem-2534	298	4	c.	c.	PROPN
eurjchem-2534	298	5	;	;	PUNCT
eurjchem-2534	298	6	cacabelos	cacabelos	PROPN
eurjchem-2534	298	7	,	,	PUNCT
eurjchem-2534	298	8	r.	r.	PROPN
eurjchem-2534	298	9	;	;	PUNCT
eurjchem-2534	298	10	lombardi	lombardi	PROPN
eurjchem-2534	298	11	,	,	PUNCT
eurjchem-2534	298	12	v.	v.	PROPN
eurjchem-2534	298	13	r.	r.	PROPN
eurjchem-2534	298	14	m.	m.	PROPN
eurjchem-2534	298	15	;	;	PUNCT
eurjchem-2534	298	16	álvarez	álvarez	PROPN
eurjchem-2534	298	17	,	,	PUNCT
eurjchem-2534	298	18	x.	x.	NOUN
eurjchem-2534	298	19	a.	a.	PROPN
eurjchem-2534	298	20	;	;	PUNCT
eurjchem-2534	298	21	vigo	vigo	PROPN
eurjchem-2534	298	22	,	,	PUNCT
eurjchem-2534	298	23	c.	c.	PROPN
eurjchem-2534	298	24	central	central	ADJ
eurjchem-2534	298	25	nervous	nervous	ADJ
eurjchem-2534	298	26	system	system	NOUN
eurjchem-2534	298	27	effects	effect	NOUN
eurjchem-2534	298	28	of	of	ADP
eurjchem-2534	298	29	celastrol	celastrol	NOUN
eurjchem-2534	298	30	,	,	PUNCT
eurjchem-2534	298	31	a	a	DET
eurjchem-2534	298	32	potent	potent	ADJ
eurjchem-2534	298	33	antioxidant	antioxidant	NOUN
eurjchem-2534	298	34	and	and	CCONJ
eurjchem-2534	298	35	antiinflammatory	antiinflammatory	NOUN
eurjchem-2534	298	36	agent	agent	NOUN
eurjchem-2534	298	37	.	.	PUNCT
eurjchem-2534	299	1	cns	cns	PROPN
eurjchem-2534	299	2	drug	drug	PROPN
eurjchem-2534	299	3	rev	rev	PROPN
eurjchem-2534	299	4	.	.	PROPN
eurjchem-2534	299	5	2000	2000	NUM
eurjchem-2534	299	6	,	,	PUNCT
eurjchem-2534	299	7	6	6	NUM
eurjchem-2534	299	8	,	,	PUNCT
eurjchem-2534	299	9	45–62	45–62	NUM
eurjchem-2534	299	10	.	.	PUNCT
eurjchem-2534	300	1	[	[	X
eurjchem-2534	300	2	5	5	NUM
eurjchem-2534	300	3	]	]	PUNCT
eurjchem-2534	300	4	.	.	PUNCT
eurjchem-2534	301	1	kim	kim	PROPN
eurjchem-2534	301	2	,	,	PUNCT
eurjchem-2534	301	3	y.	y.	PROPN
eurjchem-2534	301	4	;	;	PUNCT
eurjchem-2534	301	5	kim	kim	PROPN
eurjchem-2534	301	6	,	,	PUNCT
eurjchem-2534	301	7	k.	k.	PROPN
eurjchem-2534	301	8	;	;	PUNCT
eurjchem-2534	301	9	lee	lee	PROPN
eurjchem-2534	301	10	,	,	PUNCT
eurjchem-2534	301	11	h.	h.	PROPN
eurjchem-2534	301	12	;	;	PUNCT
eurjchem-2534	301	13	han	han	PROPN
eurjchem-2534	301	14	,	,	PUNCT
eurjchem-2534	301	15	s.	s.	PROPN
eurjchem-2534	301	16	;	;	PUNCT
eurjchem-2534	301	17	lee	lee	PROPN
eurjchem-2534	301	18	,	,	PUNCT
eurjchem-2534	301	19	y.-s	y.-	NOUN
eurjchem-2534	301	20	.	.	PUNCT
eurjchem-2534	301	21	;	;	PUNCT
eurjchem-2534	301	22	choe	choe	PROPN
eurjchem-2534	301	23	,	,	PUNCT
eurjchem-2534	301	24	j.	j.	PROPN
eurjchem-2534	301	25	;	;	PUNCT
eurjchem-2534	301	26	kim	kim	PROPN
eurjchem-2534	301	27	,	,	PUNCT
eurjchem-2534	301	28	y.-m	y.-m	PROPN
eurjchem-2534	301	29	.	.	PUNCT
eurjchem-2534	301	30	;	;	PUNCT
eurjchem-2534	301	31	hahn	hahn	PROPN
eurjchem-2534	301	32	,	,	PUNCT
eurjchem-2534	301	33	j.h	j.h	PROPN
eurjchem-2534	301	34	.	.	PROPN
eurjchem-2534	301	35	;	;	PUNCT
eurjchem-2534	301	36	ro	ro	PROPN
eurjchem-2534	301	37	,	,	PUNCT
eurjchem-2534	301	38	j.	j.	PROPN
eurjchem-2534	301	39	y.	y.	PROPN
eurjchem-2534	301	40	;	;	PUNCT
eurjchem-2534	301	41	jeoung	jeoung	PROPN
eurjchem-2534	301	42	,	,	PUNCT
eurjchem-2534	301	43	d.	d.	PROPN
eurjchem-2534	301	44	celastrol	celastrol	PROPN
eurjchem-2534	301	45	binds	bind	VERB
eurjchem-2534	301	46	to	to	ADP
eurjchem-2534	301	47	erk	erk	NOUN
eurjchem-2534	301	48	and	and	CCONJ
eurjchem-2534	301	49	inhibits	inhibit	VERB
eurjchem-2534	301	50	fcεri	fcεri	ADJ
eurjchem-2534	301	51	signaling	signal	VERB
eurjchem-2534	301	52	to	to	PART
eurjchem-2534	301	53	exert	exert	VERB
eurjchem-2534	301	54	an	an	DET
eurjchem-2534	301	55	anti	anti	ADJ
eurjchem-2534	301	56	-	-	ADJ
eurjchem-2534	301	57	allergic	allergic	ADJ
eurjchem-2534	301	58	effect	effect	NOUN
eurjchem-2534	301	59	.	.	PUNCT
eurjchem-2534	302	1	eur	eur	PROPN
eurjchem-2534	302	2	.	.	PUNCT
eurjchem-2534	303	1	j.	j.	PROPN
eurjchem-2534	303	2	pharmacol	pharmacol	PROPN
eurjchem-2534	303	3	.	.	PUNCT
eurjchem-2534	303	4	2009	2009	NUM
eurjchem-2534	303	5	,	,	PUNCT
eurjchem-2534	303	6	612	612	NUM
eurjchem-2534	303	7	,	,	PUNCT
eurjchem-2534	303	8	131–142	131–142	NUM
eurjchem-2534	303	9	.	.	PUNCT
eurjchem-2534	304	1	[	[	X
eurjchem-2534	304	2	6	6	NUM
eurjchem-2534	304	3	]	]	PUNCT
eurjchem-2534	304	4	.	.	PUNCT
eurjchem-2534	305	1	yang	yang	PROPN
eurjchem-2534	305	2	,	,	PUNCT
eurjchem-2534	305	3	g.	g.	PROPN
eurjchem-2534	305	4	;	;	PUNCT
eurjchem-2534	305	5	wang	wang	PROPN
eurjchem-2534	305	6	,	,	PUNCT
eurjchem-2534	305	7	k.	k.	PROPN
eurjchem-2534	305	8	;	;	PUNCT
eurjchem-2534	305	9	song	song	PROPN
eurjchem-2534	305	10	,	,	PUNCT
eurjchem-2534	305	11	h.	h.	PROPN
eurjchem-2534	305	12	;	;	PUNCT
eurjchem-2534	305	13	zhu	zhu	PROPN
eurjchem-2534	305	14	,	,	PUNCT
eurjchem-2534	305	15	r.	r.	PROPN
eurjchem-2534	305	16	;	;	PUNCT
eurjchem-2534	305	17	ding	ding	NOUN
eurjchem-2534	305	18	,	,	PUNCT
eurjchem-2534	305	19	s.	s.	PROPN
eurjchem-2534	305	20	;	;	PUNCT
eurjchem-2534	305	21	yang	yang	PROPN
eurjchem-2534	305	22	,	,	PUNCT
eurjchem-2534	305	23	h.	h.	PROPN
eurjchem-2534	305	24	;	;	PUNCT
eurjchem-2534	305	25	sun	sun	PROPN
eurjchem-2534	305	26	,	,	PUNCT
eurjchem-2534	305	27	j.	j.	PROPN
eurjchem-2534	305	28	;	;	PUNCT
eurjchem-2534	305	29	wen	wen	PROPN
eurjchem-2534	305	30	,	,	PUNCT
eurjchem-2534	305	31	x.	x.	PROPN
eurjchem-2534	305	32	;	;	PUNCT
eurjchem-2534	305	33	sun	sun	PROPN
eurjchem-2534	305	34	,	,	PUNCT
eurjchem-2534	305	35	l.	l.	PROPN
eurjchem-2534	305	36	celastrol	celastrol	PROPN
eurjchem-2534	305	37	ameliorates	ameliorate	VERB
eurjchem-2534	305	38	osteoarthritis	osteoarthritis	NOUN
eurjchem-2534	305	39	via	via	ADP
eurjchem-2534	305	40	regulating	regulate	VERB
eurjchem-2534	305	41	tlr2	tlr2	PROPN
eurjchem-2534	305	42	/	/	SYM
eurjchem-2534	305	43	nf	nf	NOUN
eurjchem-2534	305	44	-	-	PUNCT
eurjchem-2534	305	45	κb	κb	NOUN
eurjchem-2534	305	46	signaling	signal	VERB
eurjchem-2534	305	47	pathway	pathway	NOUN
eurjchem-2534	305	48	.	.	PUNCT
eurjchem-2534	306	1	front	front	ADJ
eurjchem-2534	306	2	.	.	PUNCT
eurjchem-2534	307	1	pharmacol	pharmacol	PROPN
eurjchem-2534	307	2	.	.	PUNCT
eurjchem-2534	308	1	2022	2022	NUM
eurjchem-2534	308	2	,	,	PUNCT
eurjchem-2534	308	3	13	13	NUM
eurjchem-2534	308	4	,	,	PUNCT
eurjchem-2534	308	5	963506	963506	NUM
eurjchem-2534	308	6	.	.	PUNCT
eurjchem-2534	309	1	[	[	X
eurjchem-2534	309	2	7	7	NUM
eurjchem-2534	309	3	]	]	PUNCT
eurjchem-2534	309	4	.	.	PUNCT
eurjchem-2534	310	1	der	der	PROPN
eurjchem-2534	310	2	sarkissian	sarkissian	PROPN
eurjchem-2534	310	3	,	,	PUNCT
eurjchem-2534	310	4	s.	s.	PROPN
eurjchem-2534	310	5	;	;	PUNCT
eurjchem-2534	310	6	cailhier	cailhier	ADV
eurjchem-2534	310	7	,	,	PUNCT
eurjchem-2534	310	8	j.	j.	PROPN
eurjchem-2534	310	9	;	;	PUNCT
eurjchem-2534	310	10	borie	borie	ADJ
eurjchem-2534	310	11	,	,	PUNCT
eurjchem-2534	310	12	m.	m.	NOUN
eurjchem-2534	310	13	;	;	PUNCT
eurjchem-2534	310	14	mansour	mansour	PROPN
eurjchem-2534	310	15	,	,	PUNCT
eurjchem-2534	310	16	s.	s.	PROPN
eurjchem-2534	310	17	;	;	PUNCT
eurjchem-2534	310	18	hamet	hamet	PROPN
eurjchem-2534	310	19	,	,	PUNCT
eurjchem-2534	310	20	p.	p.	PROPN
eurjchem-2534	310	21	;	;	PUNCT
eurjchem-2534	310	22	stevens	stevens	PROPN
eurjchem-2534	310	23	,	,	PUNCT
eurjchem-2534	310	24	l.	l.	PROPN
eurjchem-2534	310	25	;	;	PUNCT
eurjchem-2534	310	26	noiseux	noiseux	PROPN
eurjchem-2534	310	27	,	,	PUNCT
eurjchem-2534	310	28	n.	n.	NOUN
eurjchem-2534	310	29	celastrol	celastrol	NOUN
eurjchem-2534	310	30	as	as	ADP
eurjchem-2534	310	31	a	a	DET
eurjchem-2534	310	32	novel	novel	ADJ
eurjchem-2534	310	33	cardioprotective	cardioprotective	ADJ
eurjchem-2534	310	34	drug	drug	NOUN
eurjchem-2534	310	35	.	.	PUNCT
eurjchem-2534	311	1	can	can	AUX
eurjchem-2534	311	2	.	.	PUNCT
eurjchem-2534	312	1	j.	j.	PROPN
eurjchem-2534	312	2	cardiol	cardiol	PROPN
eurjchem-2534	312	3	.	.	PUNCT
eurjchem-2534	313	1	2013	2013	NUM
eurjchem-2534	313	2	,	,	PUNCT
eurjchem-2534	313	3	29	29	NUM
eurjchem-2534	313	4	,	,	PUNCT
eurjchem-2534	313	5	s331	s331	NUM
eurjchem-2534	313	6	.	.	PUNCT
eurjchem-2534	314	1	[	[	X
eurjchem-2534	314	2	8	8	NUM
eurjchem-2534	314	3	]	]	PUNCT
eurjchem-2534	314	4	.	.	PUNCT
eurjchem-2534	314	5	sun	sun	PROPN
eurjchem-2534	314	6	,	,	PUNCT
eurjchem-2534	314	7	h.	h.	PROPN
eurjchem-2534	314	8	;	;	PUNCT
eurjchem-2534	314	9	xu	xu	PROPN
eurjchem-2534	314	10	,	,	PUNCT
eurjchem-2534	314	11	l.	l.	PROPN
eurjchem-2534	314	12	;	;	PUNCT
eurjchem-2534	314	13	yu	yu	PROPN
eurjchem-2534	314	14	,	,	PUNCT
eurjchem-2534	314	15	p.	p.	PROPN
eurjchem-2534	314	16	;	;	PUNCT
eurjchem-2534	314	17	jiang	jiang	PROPN
eurjchem-2534	314	18	,	,	PUNCT
eurjchem-2534	314	19	j.	j.	PROPN
eurjchem-2534	314	20	;	;	PUNCT
eurjchem-2534	314	21	zhang	zhang	PROPN
eurjchem-2534	314	22	,	,	PUNCT
eurjchem-2534	314	23	g.	g.	PROPN
eurjchem-2534	314	24	;	;	PUNCT
eurjchem-2534	314	25	wang	wang	PROPN
eurjchem-2534	314	26	,	,	PUNCT
eurjchem-2534	314	27	y.	y.	NOUN
eurjchem-2534	314	28	synthesis	synthesis	NOUN
eurjchem-2534	314	29	and	and	CCONJ
eurjchem-2534	314	30	preliminary	preliminary	ADJ
eurjchem-2534	314	31	evaluation	evaluation	NOUN
eurjchem-2534	314	32	of	of	ADP
eurjchem-2534	314	33	neuroprotection	neuroprotection	NOUN
eurjchem-2534	314	34	of	of	ADP
eurjchem-2534	314	35	celastrol	celastrol	NOUN
eurjchem-2534	314	36	analogues	analogue	NOUN
eurjchem-2534	314	37	in	in	ADP
eurjchem-2534	314	38	pc12	pc12	PROPN
eurjchem-2534	314	39	cells	cell	NOUN
eurjchem-2534	314	40	.	.	PUNCT
eurjchem-2534	315	1	bioorg	bioorg	PROPN
eurjchem-2534	315	2	.	.	PUNCT
eurjchem-2534	316	1	med	med	PROPN
eurjchem-2534	316	2	.	.	PROPN
eurjchem-2534	316	3	chem	chem	PROPN
eurjchem-2534	316	4	.	.	PUNCT
eurjchem-2534	317	1	lett	lett	PROPN
eurjchem-2534	317	2	.	.	PUNCT
eurjchem-2534	318	1	2010	2010	NUM
eurjchem-2534	318	2	,	,	PUNCT
eurjchem-2534	318	3	20	20	NUM
eurjchem-2534	318	4	,	,	PUNCT
eurjchem-2534	318	5	3844–3847	3844–3847	NUM
eurjchem-2534	318	6	.	.	PUNCT
eurjchem-2534	319	1	[	[	X
eurjchem-2534	319	2	9	9	NUM
eurjchem-2534	319	3	]	]	PUNCT
eurjchem-2534	319	4	.	.	PUNCT
eurjchem-2534	320	1	ng	ng	PROPN
eurjchem-2534	320	2	,	,	PUNCT
eurjchem-2534	320	3	j.	j.	PROPN
eurjchem-2534	320	4	p.	p.	PROPN
eurjchem-2534	320	5	l.	l.	PROPN
eurjchem-2534	320	6	;	;	PUNCT
eurjchem-2534	320	7	han	han	PROPN
eurjchem-2534	320	8	,	,	PUNCT
eurjchem-2534	320	9	y.	y.	PROPN
eurjchem-2534	320	10	;	;	PUNCT
eurjchem-2534	320	11	yang	yang	PROPN
eurjchem-2534	320	12	,	,	PUNCT
eurjchem-2534	320	13	l.	l.	PROPN
eurjchem-2534	320	14	j.	j.	PROPN
eurjchem-2534	320	15	;	;	PUNCT
eurjchem-2534	320	16	birkholtz	birkholtz	PROPN
eurjchem-2534	320	17	,	,	PUNCT
eurjchem-2534	320	18	l.-m	l.-m	PROPN
eurjchem-2534	320	19	.	.	PUNCT
eurjchem-2534	320	20	;	;	PUNCT
eurjchem-2534	320	21	coertzen	coertzen	PROPN
eurjchem-2534	320	22	,	,	PUNCT
eurjchem-2534	320	23	d.	d.	PROPN
eurjchem-2534	320	24	;	;	PUNCT
eurjchem-2534	320	25	wong	wong	PROPN
eurjchem-2534	320	26	,	,	PUNCT
eurjchem-2534	320	27	h.	h.	PROPN
eurjchem-2534	320	28	n.	n.	PROPN
eurjchem-2534	320	29	;	;	PUNCT
eurjchem-2534	320	30	haynes	haynes	PROPN
eurjchem-2534	320	31	,	,	PUNCT
eurjchem-2534	320	32	r.	r.	PROPN
eurjchem-2534	320	33	k.	k.	PROPN
eurjchem-2534	320	34	;	;	PUNCT
eurjchem-2534	320	35	coghi	coghi	PROPN
eurjchem-2534	320	36	,	,	PUNCT
eurjchem-2534	320	37	p.	p.	NOUN
eurjchem-2534	320	38	;	;	PUNCT
eurjchem-2534	320	39	wong	wong	PROPN
eurjchem-2534	320	40	,	,	PUNCT
eurjchem-2534	320	41	v.	v.	PROPN
eurjchem-2534	320	42	k.	k.	PROPN
eurjchem-2534	320	43	w.	w.	PROPN
eurjchem-2534	320	44	antimalarial	antimalarial	PROPN
eurjchem-2534	320	45	and	and	CCONJ
eurjchem-2534	320	46	antitumour	antitumour	NOUN
eurjchem-2534	320	47	activities	activity	NOUN
eurjchem-2534	320	48	of	of	ADP
eurjchem-2534	320	49	the	the	DET
eurjchem-2534	320	50	steroidal	steroidal	NOUN
eurjchem-2534	320	51	quinone	quinone	NOUN
eurjchem-2534	320	52	-	-	PUNCT
eurjchem-2534	320	53	methide	methide	NOUN
eurjchem-2534	320	54	celastrol	celastrol	NOUN
eurjchem-2534	320	55	and	and	CCONJ
eurjchem-2534	320	56	its	its	PRON
eurjchem-2534	320	57	combinations	combination	NOUN
eurjchem-2534	320	58	with	with	ADP
eurjchem-2534	320	59	artemiside	artemiside	NOUN
eurjchem-2534	320	60	,	,	PUNCT
eurjchem-2534	320	61	artemisone	artemisone	NOUN
eurjchem-2534	320	62	and	and	CCONJ
eurjchem-2534	320	63	methylene	methylene	NOUN
eurjchem-2534	320	64	blue	blue	NOUN
eurjchem-2534	320	65	.	.	PUNCT
eurjchem-2534	321	1	front	front	NOUN
eurjchem-2534	321	2	.	.	PUNCT
eurjchem-2534	322	1	pharmacol	pharmacol	PROPN
eurjchem-2534	322	2	.	.	PUNCT
eurjchem-2534	323	1	2022	2022	NUM
eurjchem-2534	323	2	,	,	PUNCT
eurjchem-2534	323	3	13	13	NUM
eurjchem-2534	323	4	,	,	PUNCT
eurjchem-2534	323	5	988748	988748	NUM
eurjchem-2534	323	6	.	.	PUNCT
eurjchem-2534	324	1	[	[	X
eurjchem-2534	324	2	10	10	NUM
eurjchem-2534	324	3	]	]	PUNCT
eurjchem-2534	324	4	.	.	PUNCT
eurjchem-2534	325	1	liu	liu	PROPN
eurjchem-2534	325	2	,	,	PUNCT
eurjchem-2534	325	3	j.	j.	PROPN
eurjchem-2534	325	4	;	;	PUNCT
eurjchem-2534	325	5	lee	lee	PROPN
eurjchem-2534	325	6	,	,	PUNCT
eurjchem-2534	325	7	j.	j.	PROPN
eurjchem-2534	325	8	;	;	PUNCT
eurjchem-2534	325	9	salazar	salazar	PROPN
eurjchem-2534	325	10	hernandez	hernandez	PROPN
eurjchem-2534	325	11	,	,	PUNCT
eurjchem-2534	325	12	m.	m.	NOUN
eurjchem-2534	325	13	a.	a.	PROPN
eurjchem-2534	325	14	;	;	PUNCT
eurjchem-2534	325	15	mazitschek	mazitschek	PROPN
eurjchem-2534	325	16	,	,	PUNCT
eurjchem-2534	325	17	r.	r.	PROPN
eurjchem-2534	325	18	;	;	PUNCT
eurjchem-2534	325	19	ozcan	ozcan	ADV
eurjchem-2534	325	20	,	,	PUNCT
eurjchem-2534	325	21	u.	u.	NOUN
eurjchem-2534	325	22	treatment	treatment	NOUN
eurjchem-2534	325	23	of	of	ADP
eurjchem-2534	325	24	obesity	obesity	NOUN
eurjchem-2534	325	25	with	with	ADP
eurjchem-2534	325	26	celastrol	celastrol	NOUN
eurjchem-2534	325	27	.	.	PUNCT
eurjchem-2534	326	1	cell	cell	NOUN
eurjchem-2534	326	2	2015	2015	NUM
eurjchem-2534	326	3	,	,	PUNCT
eurjchem-2534	326	4	161	161	NUM
eurjchem-2534	326	5	,	,	PUNCT
eurjchem-2534	326	6	999–1011	999–1011	NUM
eurjchem-2534	326	7	.	.	PUNCT
eurjchem-2534	327	1	[	[	X
eurjchem-2534	327	2	11	11	NUM
eurjchem-2534	327	3	]	]	PUNCT
eurjchem-2534	327	4	.	.	PUNCT
eurjchem-2534	328	1	jang	jang	PROPN
eurjchem-2534	328	2	,	,	PUNCT
eurjchem-2534	328	3	s.	s.	PROPN
eurjchem-2534	328	4	y.	y.	PROPN
eurjchem-2534	328	5	;	;	PUNCT
eurjchem-2534	328	6	jang	jang	PROPN
eurjchem-2534	328	7	,	,	PUNCT
eurjchem-2534	328	8	s.-w	s.-w	PROPN
eurjchem-2534	328	9	.	.	PUNCT
eurjchem-2534	328	10	;	;	PUNCT
eurjchem-2534	328	11	ko	ko	PROPN
eurjchem-2534	328	12	,	,	PUNCT
eurjchem-2534	328	13	j.	j.	PROPN
eurjchem-2534	328	14	celastrol	celastrol	PROPN
eurjchem-2534	328	15	inhibits	inhibit	VERB
eurjchem-2534	328	16	the	the	DET
eurjchem-2534	328	17	growth	growth	NOUN
eurjchem-2534	328	18	of	of	ADP
eurjchem-2534	328	19	estrogen	estrogen	NOUN
eurjchem-2534	328	20	positive	positive	ADJ
eurjchem-2534	328	21	human	human	ADJ
eurjchem-2534	328	22	breast	breast	NOUN
eurjchem-2534	328	23	cancer	cancer	NOUN
eurjchem-2534	328	24	cells	cell	NOUN
eurjchem-2534	328	25	through	through	ADP
eurjchem-2534	328	26	modulation	modulation	NOUN
eurjchem-2534	328	27	of	of	ADP
eurjchem-2534	328	28	estrogen	estrogen	NOUN
eurjchem-2534	328	29	receptor	receptor	NOUN
eurjchem-2534	328	30	α	α	NOUN
eurjchem-2534	328	31	.	.	PUNCT
eurjchem-2534	329	1	cancer	cancer	PROPN
eurjchem-2534	329	2	lett	lett	PROPN
eurjchem-2534	329	3	.	.	PUNCT
eurjchem-2534	330	1	2011	2011	NUM
eurjchem-2534	330	2	,	,	PUNCT
eurjchem-2534	330	3	300	300	NUM
eurjchem-2534	330	4	,	,	PUNCT
eurjchem-2534	330	5	57–65	57–65	NUM
eurjchem-2534	330	6	.	.	PUNCT
eurjchem-2534	331	1	[	[	X
eurjchem-2534	331	2	12	12	NUM
eurjchem-2534	331	3	]	]	PUNCT
eurjchem-2534	331	4	.	.	PUNCT
eurjchem-2534	332	1	mi	mi	PROPN
eurjchem-2534	332	2	,	,	PUNCT
eurjchem-2534	332	3	c.	c.	PROPN
eurjchem-2534	332	4	;	;	PUNCT
eurjchem-2534	332	5	shi	shi	PROPN
eurjchem-2534	332	6	,	,	PUNCT
eurjchem-2534	332	7	h.	h.	PROPN
eurjchem-2534	332	8	;	;	PUNCT
eurjchem-2534	332	9	ma	ma	PROPN
eurjchem-2534	332	10	,	,	PUNCT
eurjchem-2534	332	11	j.	j.	PROPN
eurjchem-2534	332	12	;	;	PUNCT
eurjchem-2534	332	13	han	han	PROPN
eurjchem-2534	332	14	,	,	PUNCT
eurjchem-2534	332	15	l.	l.	PROPN
eurjchem-2534	332	16	i.	i.	PROPN
eurjchem-2534	332	17	z.	z.	PROPN
eurjchem-2534	332	18	;	;	PUNCT
eurjchem-2534	332	19	lee	lee	PROPN
eurjchem-2534	332	20	,	,	PUNCT
eurjchem-2534	332	21	j.	j.	PROPN
eurjchem-2534	332	22	j.	j.	PROPN
eurjchem-2534	332	23	;	;	PUNCT
eurjchem-2534	332	24	jin	jin	PROPN
eurjchem-2534	332	25	,	,	PUNCT
eurjchem-2534	332	26	x.	x.	NOUN
eurjchem-2534	332	27	celastrol	celastrol	PROPN
eurjchem-2534	332	28	induces	induce	VERB
eurjchem-2534	332	29	the	the	DET
eurjchem-2534	332	30	apoptosis	apoptosis	NOUN
eurjchem-2534	332	31	of	of	ADP
eurjchem-2534	332	32	breast	breast	NOUN
eurjchem-2534	332	33	cancer	cancer	NOUN
eurjchem-2534	332	34	cells	cell	NOUN
eurjchem-2534	332	35	and	and	CCONJ
eurjchem-2534	332	36	inhibits	inhibit	VERB
eurjchem-2534	332	37	their	their	PRON
eurjchem-2534	332	38	invasion	invasion	NOUN
eurjchem-2534	332	39	via	via	ADP
eurjchem-2534	332	40	downregulation	downregulation	NOUN
eurjchem-2534	332	41	of	of	ADP
eurjchem-2534	332	42	mmp-9	mmp-9	NOUN
eurjchem-2534	332	43	.	.	PUNCT
eurjchem-2534	333	1	oncol	oncol	PROPN
eurjchem-2534	333	2	.	.	PUNCT
eurjchem-2534	334	1	rep	rep	PROPN
eurjchem-2534	334	2	.	.	PROPN
eurjchem-2534	334	3	2014	2014	NUM
eurjchem-2534	334	4	,	,	PUNCT
eurjchem-2534	334	5	32	32	NUM
eurjchem-2534	334	6	,	,	PUNCT
eurjchem-2534	334	7	2527–2532	2527–2532	NUM
eurjchem-2534	334	8	.	.	PUNCT
eurjchem-2534	335	1	[	[	X
eurjchem-2534	335	2	13	13	NUM
eurjchem-2534	335	3	]	]	PUNCT
eurjchem-2534	335	4	.	.	PUNCT
eurjchem-2534	336	1	li	li	PROPN
eurjchem-2534	336	2	,	,	PUNCT
eurjchem-2534	336	3	x.	x.	PROPN
eurjchem-2534	336	4	;	;	PUNCT
eurjchem-2534	336	5	ding	ding	PROPN
eurjchem-2534	336	6	,	,	PUNCT
eurjchem-2534	336	7	j.	j.	PROPN
eurjchem-2534	336	8	;	;	PUNCT
eurjchem-2534	336	9	li	li	PROPN
eurjchem-2534	336	10	,	,	PUNCT
eurjchem-2534	336	11	n.	n.	PROPN
eurjchem-2534	336	12	;	;	PUNCT
eurjchem-2534	336	13	liu	liu	PROPN
eurjchem-2534	336	14	,	,	PUNCT
eurjchem-2534	336	15	w.	w.	PROPN
eurjchem-2534	336	16	;	;	PUNCT
eurjchem-2534	336	17	ding	ding	PROPN
eurjchem-2534	336	18	,	,	PUNCT
eurjchem-2534	336	19	f.	f.	PROPN
eurjchem-2534	336	20	;	;	PUNCT
eurjchem-2534	336	21	zheng	zheng	PROPN
eurjchem-2534	336	22	,	,	PUNCT
eurjchem-2534	336	23	h.	h.	PROPN
eurjchem-2534	336	24	;	;	PUNCT
eurjchem-2534	336	25	ning	ning	PROPN
eurjchem-2534	336	26	,	,	PUNCT
eurjchem-2534	336	27	y.	y.	PROPN
eurjchem-2534	336	28	;	;	PUNCT
eurjchem-2534	336	29	wang	wang	PROPN
eurjchem-2534	336	30	,	,	PUNCT
eurjchem-2534	336	31	h.	h.	PROPN
eurjchem-2534	336	32	;	;	PUNCT
eurjchem-2534	336	33	liu	liu	PROPN
eurjchem-2534	336	34	,	,	PUNCT
eurjchem-2534	336	35	r.	r.	PROPN
eurjchem-2534	336	36	;	;	PUNCT
eurjchem-2534	336	37	ren	ren	PROPN
eurjchem-2534	336	38	,	,	PUNCT
eurjchem-2534	336	39	s.	s.	PROPN
eurjchem-2534	336	40	synthesis	synthesis	NOUN
eurjchem-2534	336	41	and	and	CCONJ
eurjchem-2534	336	42	biological	biological	ADJ
eurjchem-2534	336	43	evaluation	evaluation	NOUN
eurjchem-2534	336	44	of	of	ADP
eurjchem-2534	336	45	celastrol	celastrol	NOUN
eurjchem-2534	336	46	derivatives	derivative	NOUN
eurjchem-2534	336	47	as	as	ADP
eurjchem-2534	336	48	anti	anti	ADJ
eurjchem-2534	336	49	-	-	ADJ
eurjchem-2534	336	50	ovarian	ovarian	ADJ
eurjchem-2534	336	51	cancer	cancer	NOUN
eurjchem-2534	336	52	stem	stem	NOUN
eurjchem-2534	336	53	cell	cell	NOUN
eurjchem-2534	336	54	agents	agent	NOUN
eurjchem-2534	336	55	.	.	PUNCT
eurjchem-2534	337	1	eur	eur	PROPN
eurjchem-2534	337	2	.	.	PUNCT
eurjchem-2534	338	1	j.	j.	PROPN
eurjchem-2534	338	2	med	med	PROPN
eurjchem-2534	338	3	.	.	PROPN
eurjchem-2534	338	4	chem	chem	PROPN
eurjchem-2534	338	5	.	.	PUNCT
eurjchem-2534	339	1	2019	2019	NUM
eurjchem-2534	339	2	,	,	PUNCT
eurjchem-2534	339	3	179	179	NUM
eurjchem-2534	339	4	,	,	PUNCT
eurjchem-2534	339	5	667–679	667–679	NUM
eurjchem-2534	339	6	.	.	PUNCT
eurjchem-2534	340	1	[	[	X
eurjchem-2534	340	2	14	14	NUM
eurjchem-2534	340	3	]	]	PUNCT
eurjchem-2534	340	4	.	.	PUNCT
eurjchem-2534	341	1	yadav	yadav	PROPN
eurjchem-2534	341	2	,	,	PUNCT
eurjchem-2534	341	3	v.	v.	PROPN
eurjchem-2534	341	4	r.	r.	PROPN
eurjchem-2534	341	5	;	;	PUNCT
eurjchem-2534	341	6	sung	sung	PROPN
eurjchem-2534	341	7	,	,	PUNCT
eurjchem-2534	341	8	b.	b.	PROPN
eurjchem-2534	341	9	;	;	PUNCT
eurjchem-2534	341	10	prasad	prasad	PROPN
eurjchem-2534	341	11	,	,	PUNCT
eurjchem-2534	341	12	s.	s.	PROPN
eurjchem-2534	341	13	;	;	PUNCT
eurjchem-2534	341	14	kannappan	kannappan	NOUN
eurjchem-2534	341	15	,	,	PUNCT
eurjchem-2534	341	16	r.	r.	PROPN
eurjchem-2534	341	17	;	;	PUNCT
eurjchem-2534	341	18	cho	cho	PROPN
eurjchem-2534	341	19	,	,	PUNCT
eurjchem-2534	341	20	s.-g	s.-g	PROPN
eurjchem-2534	341	21	.	.	PUNCT
eurjchem-2534	341	22	;	;	PUNCT
eurjchem-2534	342	1	liu	liu	PROPN
eurjchem-2534	342	2	,	,	PUNCT
eurjchem-2534	342	3	m.	m.	NOUN
eurjchem-2534	342	4	;	;	PUNCT
eurjchem-2534	342	5	chaturvedi	chaturvedi	PROPN
eurjchem-2534	342	6	,	,	PUNCT
eurjchem-2534	342	7	m.	m.	NOUN
eurjchem-2534	342	8	m.	m.	NOUN
eurjchem-2534	342	9	;	;	PUNCT
eurjchem-2534	342	10	aggarwal	aggarwal	PROPN
eurjchem-2534	342	11	,	,	PUNCT
eurjchem-2534	342	12	b.	b.	PROPN
eurjchem-2534	342	13	b.	b.	PROPN
eurjchem-2534	342	14	celastrol	celastrol	PROPN
eurjchem-2534	342	15	suppresses	suppress	VERB
eurjchem-2534	342	16	invasion	invasion	NOUN
eurjchem-2534	342	17	of	of	ADP
eurjchem-2534	342	18	colon	colon	NOUN
eurjchem-2534	342	19	and	and	CCONJ
eurjchem-2534	342	20	pancreatic	pancreatic	ADJ
eurjchem-2534	342	21	cancer	cancer	NOUN
eurjchem-2534	342	22	cells	cell	NOUN
eurjchem-2534	342	23	through	through	ADP
eurjchem-2534	342	24	the	the	DET
eurjchem-2534	342	25	downregulation	downregulation	NOUN
eurjchem-2534	342	26	of	of	ADP
eurjchem-2534	342	27	expression	expression	NOUN
eurjchem-2534	342	28	of	of	ADP
eurjchem-2534	342	29	cxcr4	cxcr4	NOUN
eurjchem-2534	342	30	chemokine	chemokine	ADJ
eurjchem-2534	342	31	receptor	receptor	NOUN
eurjchem-2534	342	32	.	.	PUNCT
eurjchem-2534	343	1	j.	j.	PROPN
eurjchem-2534	343	2	mol	mol	PROPN
eurjchem-2534	343	3	.	.	PROPN
eurjchem-2534	343	4	med	med	PROPN
eurjchem-2534	343	5	.	.	PROPN
eurjchem-2534	344	1	2010	2010	NUM
eurjchem-2534	344	2	,	,	PUNCT
eurjchem-2534	344	3	88	88	NUM
eurjchem-2534	344	4	,	,	PUNCT
eurjchem-2534	344	5	1243	1243	NUM
eurjchem-2534	344	6	–	–	PUNCT
eurjchem-2534	344	7	1253	1253	NUM
eurjchem-2534	344	8	.	.	PUNCT
eurjchem-2534	345	1	[	[	X
eurjchem-2534	345	2	15	15	NUM
eurjchem-2534	345	3	]	]	PUNCT
eurjchem-2534	345	4	.	.	PUNCT
eurjchem-2534	345	5	song	song	PROPN
eurjchem-2534	345	6	,	,	PUNCT
eurjchem-2534	345	7	j.	j.	PROPN
eurjchem-2534	345	8	;	;	PUNCT
eurjchem-2534	345	9	he	he	PRON
eurjchem-2534	345	10	,	,	PUNCT
eurjchem-2534	345	11	g.-n	g.-n	PROPN
eurjchem-2534	345	12	.	.	PUNCT
eurjchem-2534	345	13	;	;	PUNCT
eurjchem-2534	345	14	dai	dai	PROPN
eurjchem-2534	345	15	,	,	PUNCT
eurjchem-2534	345	16	l.	l.	PROPN
eurjchem-2534	345	17	a	a	DET
eurjchem-2534	345	18	comprehensive	comprehensive	ADJ
eurjchem-2534	345	19	review	review	NOUN
eurjchem-2534	345	20	on	on	ADP
eurjchem-2534	345	21	celastrol	celastrol	NOUN
eurjchem-2534	345	22	,	,	PUNCT
eurjchem-2534	345	23	triptolide	triptolide	NOUN
eurjchem-2534	345	24	and	and	CCONJ
eurjchem-2534	345	25	triptonide	triptonide	ADV
eurjchem-2534	345	26	:	:	PUNCT
eurjchem-2534	345	27	insights	insight	NOUN
eurjchem-2534	345	28	on	on	ADP
eurjchem-2534	345	29	their	their	PRON
eurjchem-2534	345	30	pharmacological	pharmacological	ADJ
eurjchem-2534	345	31	activity	activity	NOUN
eurjchem-2534	345	32	,	,	PUNCT
eurjchem-2534	345	33	toxicity	toxicity	NOUN
eurjchem-2534	345	34	,	,	PUNCT
eurjchem-2534	345	35	combination	combination	NOUN
eurjchem-2534	345	36	therapy	therapy	NOUN
eurjchem-2534	345	37	,	,	PUNCT
eurjchem-2534	345	38	new	new	ADJ
eurjchem-2534	345	39	dosage	dosage	NOUN
eurjchem-2534	345	40	form	form	NOUN
eurjchem-2534	345	41	and	and	CCONJ
eurjchem-2534	345	42	novel	novel	ADJ
eurjchem-2534	345	43	drug	drug	NOUN
eurjchem-2534	345	44	delivery	delivery	NOUN
eurjchem-2534	345	45	routes	route	NOUN
eurjchem-2534	345	46	.	.	PUNCT
eurjchem-2534	345	47	biomed	biome	VERB
eurjchem-2534	345	48	.	.	PUNCT
eurjchem-2534	346	1	pharmacother	pharmacother	ADJ
eurjchem-2534	346	2	.	.	PUNCT
eurjchem-2534	347	1	2023	2023	NUM
eurjchem-2534	347	2	,	,	PUNCT
eurjchem-2534	347	3	162	162	NUM
eurjchem-2534	347	4	,	,	PUNCT
eurjchem-2534	347	5	114705	114705	NUM
eurjchem-2534	347	6	.	.	PUNCT
eurjchem-2534	348	1	[	[	X
eurjchem-2534	348	2	16	16	NUM
eurjchem-2534	348	3	]	]	PUNCT
eurjchem-2534	348	4	.	.	PUNCT
eurjchem-2534	349	1	zhang	zhang	PROPN
eurjchem-2534	349	2	,	,	PUNCT
eurjchem-2534	349	3	t.	t.	PROPN
eurjchem-2534	349	4	;	;	PUNCT
eurjchem-2534	349	5	li	li	PROPN
eurjchem-2534	349	6	,	,	PUNCT
eurjchem-2534	349	7	y.	y.	PROPN
eurjchem-2534	349	8	;	;	PUNCT
eurjchem-2534	349	9	yu	yu	PROPN
eurjchem-2534	349	10	,	,	PUNCT
eurjchem-2534	349	11	y.	y.	PROPN
eurjchem-2534	349	12	;	;	PUNCT
eurjchem-2534	349	13	zou	zou	PROPN
eurjchem-2534	349	14	,	,	PUNCT
eurjchem-2534	349	15	p.	p.	PROPN
eurjchem-2534	349	16	;	;	PUNCT
eurjchem-2534	349	17	jiang	jiang	PROPN
eurjchem-2534	349	18	,	,	PUNCT
eurjchem-2534	349	19	y.	y.	PROPN
eurjchem-2534	349	20	;	;	PUNCT
eurjchem-2534	349	21	sun	sun	PROPN
eurjchem-2534	349	22	,	,	PUNCT
eurjchem-2534	349	23	d.	d.	PROPN
eurjchem-2534	349	24	characterization	characterization	NOUN
eurjchem-2534	349	25	of	of	ADP
eurjchem-2534	349	26	celastrol	celastrol	NOUN
eurjchem-2534	349	27	to	to	PART
eurjchem-2534	349	28	inhibit	inhibit	VERB
eurjchem-2534	349	29	hsp90	hsp90	ADJ
eurjchem-2534	349	30	and	and	CCONJ
eurjchem-2534	349	31	cdc37	cdc37	NOUN
eurjchem-2534	349	32	interaction	interaction	NOUN
eurjchem-2534	349	33	.	.	PUNCT
eurjchem-2534	350	1	j.	j.	PROPN
eurjchem-2534	350	2	biol	biol	PROPN
eurjchem-2534	350	3	.	.	PUNCT
eurjchem-2534	351	1	chem	chem	PROPN
eurjchem-2534	351	2	.	.	PUNCT
eurjchem-2534	352	1	2009	2009	NUM
eurjchem-2534	352	2	,	,	PUNCT
eurjchem-2534	352	3	284	284	NUM
eurjchem-2534	352	4	,	,	PUNCT
eurjchem-2534	352	5	35381–35389	35381–35389	NUM
eurjchem-2534	352	6	.	.	PUNCT
eurjchem-2534	353	1	[	[	X
eurjchem-2534	353	2	17	17	NUM
eurjchem-2534	353	3	]	]	PUNCT
eurjchem-2534	353	4	.	.	PUNCT
eurjchem-2534	354	1	jin	jin	PROPN
eurjchem-2534	354	2	,	,	PUNCT
eurjchem-2534	354	3	h.	h.	PROPN
eurjchem-2534	354	4	z.	z.	PROPN
eurjchem-2534	354	5	;	;	PUNCT
eurjchem-2534	354	6	hwang	hwang	PROPN
eurjchem-2534	354	7	,	,	PUNCT
eurjchem-2534	354	8	b.	b.	PROPN
eurjchem-2534	354	9	y.	y.	PROPN
eurjchem-2534	354	10	;	;	PUNCT
eurjchem-2534	354	11	kim	kim	PROPN
eurjchem-2534	354	12	,	,	PUNCT
eurjchem-2534	354	13	h.	h.	PROPN
eurjchem-2534	354	14	s.	s.	PROPN
eurjchem-2534	354	15	;	;	PUNCT
eurjchem-2534	354	16	lee	lee	PROPN
eurjchem-2534	354	17	,	,	PUNCT
eurjchem-2534	354	18	j.	j.	PROPN
eurjchem-2534	354	19	h.	h.	PROPN
eurjchem-2534	354	20	;	;	PUNCT
eurjchem-2534	354	21	kim	kim	PROPN
eurjchem-2534	354	22	,	,	PUNCT
eurjchem-2534	354	23	y.	y.	PROPN
eurjchem-2534	354	24	h.	h.	PROPN
eurjchem-2534	354	25	;	;	PUNCT
eurjchem-2534	354	26	lee	lee	PROPN
eurjchem-2534	354	27	,	,	PUNCT
eurjchem-2534	354	28	j.	j.	PROPN
eurjchem-2534	354	29	j.	j.	PROPN
eurjchem-2534	354	30	antiinflammatory	antiinflammatory	PROPN
eurjchem-2534	354	31	constituents	constituent	NOUN
eurjchem-2534	354	32	of	of	ADP
eurjchem-2534	354	33	celastrus	celastrus	NOUN
eurjchem-2534	354	34	orbiculatus	orbiculatus	NOUN
eurjchem-2534	354	35	inhibit	inhibit	VERB
eurjchem-2534	354	36	the	the	DET
eurjchem-2534	354	37	nfκb	nfκb	ADJ
eurjchem-2534	354	38	activation	activation	NOUN
eurjchem-2534	354	39	and	and	CCONJ
eurjchem-2534	354	40	no	no	DET
eurjchem-2534	354	41	production	production	NOUN
eurjchem-2534	354	42	.	.	PUNCT
eurjchem-2534	355	1	j.	j.	PROPN
eurjchem-2534	355	2	nat	nat	PROPN
eurjchem-2534	355	3	.	.	PUNCT
eurjchem-2534	356	1	prod	prod	PROPN
eurjchem-2534	356	2	.	.	PUNCT
eurjchem-2534	357	1	2002	2002	NUM
eurjchem-2534	357	2	,	,	PUNCT
eurjchem-2534	357	3	65	65	NUM
eurjchem-2534	357	4	,	,	PUNCT
eurjchem-2534	357	5	89–91	89–91	NUM
eurjchem-2534	357	6	.	.	PUNCT
eurjchem-2534	358	1	[	[	X
eurjchem-2534	358	2	18	18	NUM
eurjchem-2534	358	3	]	]	PUNCT
eurjchem-2534	358	4	.	.	PUNCT
eurjchem-2534	359	1	sreeramulu	sreeramulu	PROPN
eurjchem-2534	359	2	,	,	PUNCT
eurjchem-2534	359	3	s.	s.	PROPN
eurjchem-2534	359	4	;	;	PUNCT
eurjchem-2534	359	5	gande	gande	PROPN
eurjchem-2534	359	6	,	,	PUNCT
eurjchem-2534	359	7	s.	s.	PROPN
eurjchem-2534	359	8	l.	l.	PROPN
eurjchem-2534	359	9	;	;	PUNCT
eurjchem-2534	359	10	göbel	göbel	NOUN
eurjchem-2534	359	11	,	,	PUNCT
eurjchem-2534	359	12	m.	m.	NOUN
eurjchem-2534	359	13	;	;	PUNCT
eurjchem-2534	359	14	schwalbe	schwalbe	NOUN
eurjchem-2534	359	15	,	,	PUNCT
eurjchem-2534	359	16	h.	h.	PROPN
eurjchem-2534	359	17	molecular	molecular	ADJ
eurjchem-2534	359	18	mechanism	mechanism	NOUN
eurjchem-2534	359	19	of	of	ADP
eurjchem-2534	359	20	inhibition	inhibition	NOUN
eurjchem-2534	359	21	of	of	ADP
eurjchem-2534	359	22	the	the	DET
eurjchem-2534	359	23	human	human	ADJ
eurjchem-2534	359	24	protein	protein	NOUN
eurjchem-2534	359	25	complex	complex	ADJ
eurjchem-2534	359	26	hsp90	hsp90	ADJ
eurjchem-2534	359	27	–	–	PUNCT
eurjchem-2534	359	28	cdc37	cdc37	NOUN
eurjchem-2534	359	29	,	,	PUNCT
eurjchem-2534	359	30	a	a	DET
eurjchem-2534	359	31	kinome	kinome	NOUN
eurjchem-2534	359	32	chaperone	chaperone	NOUN
eurjchem-2534	359	33	–	–	PUNCT
eurjchem-2534	359	34	cochaperone	cochaperone	NOUN
eurjchem-2534	359	35	,	,	PUNCT
eurjchem-2534	359	36	by	by	ADP
eurjchem-2534	359	37	triterpene	triterpene	ADJ
eurjchem-2534	359	38	celastrol	celastrol	NOUN
eurjchem-2534	359	39	.	.	PUNCT
eurjchem-2534	360	1	angew	angew	PROPN
eurjchem-2534	360	2	.	.	PUNCT
eurjchem-2534	361	1	chem	chem	PROPN
eurjchem-2534	361	2	.	.	PUNCT
eurjchem-2534	362	1	int	int	NOUN
eurjchem-2534	362	2	.	.	PUNCT
eurjchem-2534	363	1	ed	ed	PROPN
eurjchem-2534	363	2	engl	engl	PROPN
eurjchem-2534	363	3	.	.	PROPN
eurjchem-2534	363	4	2009	2009	NUM
eurjchem-2534	363	5	,	,	PUNCT
eurjchem-2534	363	6	48	48	NUM
eurjchem-2534	363	7	,	,	PUNCT
eurjchem-2534	363	8	5853–5855	5853–5855	NUM
eurjchem-2534	363	9	.	.	PUNCT
eurjchem-2534	364	1	[	[	X
eurjchem-2534	364	2	19	19	NUM
eurjchem-2534	364	3	]	]	PUNCT
eurjchem-2534	364	4	.	.	PUNCT
eurjchem-2534	365	1	clapham	clapham	PROPN
eurjchem-2534	365	2	,	,	PUNCT
eurjchem-2534	365	3	d.	d.	PROPN
eurjchem-2534	365	4	e.	e.	PROPN
eurjchem-2534	365	5	calcium	calcium	PROPN
eurjchem-2534	365	6	signaling	signal	VERB
eurjchem-2534	365	7	.	.	PUNCT
eurjchem-2534	366	1	cell	cell	NOUN
eurjchem-2534	366	2	2007	2007	NUM
eurjchem-2534	366	3	,	,	PUNCT
eurjchem-2534	366	4	131	131	NUM
eurjchem-2534	366	5	,	,	PUNCT
eurjchem-2534	366	6	1047–1058	1047–1058	NUM
eurjchem-2534	366	7	.	.	PUNCT
eurjchem-2534	367	1	[	[	X
eurjchem-2534	367	2	20	20	NUM
eurjchem-2534	367	3	]	]	PUNCT
eurjchem-2534	367	4	.	.	PUNCT
eurjchem-2534	368	1	mooren	mooren	PROPN
eurjchem-2534	368	2	,	,	PUNCT
eurjchem-2534	368	3	f.	f.	PROPN
eurjchem-2534	368	4	c.	c.	PROPN
eurjchem-2534	368	5	;	;	PUNCT
eurjchem-2534	368	6	kinne	kinne	PROPN
eurjchem-2534	368	7	,	,	PUNCT
eurjchem-2534	368	8	r.	r.	PROPN
eurjchem-2534	368	9	k.	k.	PROPN
eurjchem-2534	368	10	h.	h.	PROPN
eurjchem-2534	368	11	cellular	cellular	ADJ
eurjchem-2534	368	12	calcium	calcium	NOUN
eurjchem-2534	368	13	in	in	ADP
eurjchem-2534	368	14	health	health	NOUN
eurjchem-2534	368	15	and	and	CCONJ
eurjchem-2534	368	16	disease	disease	NOUN
eurjchem-2534	368	17	.	.	PUNCT
eurjchem-2534	369	1	biochim	biochim	PROPN
eurjchem-2534	369	2	.	.	PUNCT
eurjchem-2534	370	1	biophys	biophy	NOUN
eurjchem-2534	370	2	.	.	PUNCT
eurjchem-2534	371	1	acta	acta	PROPN
eurjchem-2534	371	2	mol	mol	PROPN
eurjchem-2534	371	3	.	.	PROPN
eurjchem-2534	372	1	basis	basis	NOUN
eurjchem-2534	372	2	dis	dis	PROPN
eurjchem-2534	372	3	.	.	PUNCT
eurjchem-2534	373	1	1998	1998	NUM
eurjchem-2534	373	2	,	,	PUNCT
eurjchem-2534	373	3	1406	1406	NUM
eurjchem-2534	373	4	,	,	PUNCT
eurjchem-2534	373	5	127–151	127–151	NUM
eurjchem-2534	373	6	.	.	PUNCT
eurjchem-2534	374	1	[	[	X
eurjchem-2534	374	2	21	21	NUM
eurjchem-2534	374	3	]	]	PUNCT
eurjchem-2534	374	4	.	.	PUNCT
eurjchem-2534	375	1	izquierdo	izquierdo	PROPN
eurjchem-2534	375	2	,	,	PUNCT
eurjchem-2534	375	3	j.-h	j.-h	PROPN
eurjchem-2534	375	4	.	.	PUNCT
eurjchem-2534	375	5	;	;	PUNCT
eurjchem-2534	375	6	bonilla	bonilla	NOUN
eurjchem-2534	375	7	-	-	PUNCT
eurjchem-2534	375	8	abadía	abadía	PROPN
eurjchem-2534	375	9	,	,	PUNCT
eurjchem-2534	375	10	f.	f.	PROPN
eurjchem-2534	375	11	;	;	PUNCT
eurjchem-2534	375	12	cañas	cañas	PROPN
eurjchem-2534	375	13	,	,	PUNCT
eurjchem-2534	375	14	c.	c.	PROPN
eurjchem-2534	375	15	a.	a.	PROPN
eurjchem-2534	375	16	;	;	PUNCT
eurjchem-2534	375	17	tobón	tobón	NOUN
eurjchem-2534	375	18	,	,	PUNCT
eurjchem-2534	375	19	g.	g.	PROPN
eurjchem-2534	375	20	j.	j.	PROPN
eurjchem-2534	375	21	calcio	calcio	PROPN
eurjchem-2534	375	22	,	,	PUNCT
eurjchem-2534	375	23	canales	canale	NOUN
eurjchem-2534	375	24	,	,	PUNCT
eurjchem-2534	375	25	señalización	señalización	VERB
eurjchem-2534	375	26	intracelular	intracelular	ADJ
eurjchem-2534	375	27	y	y	PROPN
eurjchem-2534	375	28	autoinmunidad	autoinmunidad	PROPN
eurjchem-2534	375	29	.	.	PUNCT
eurjchem-2534	376	1	reumatol	reumatol	ADJ
eurjchem-2534	376	2	.	.	PUNCT
eurjchem-2534	377	1	clin	clin	PROPN
eurjchem-2534	377	2	.	.	PUNCT
eurjchem-2534	378	1	2014	2014	NUM
eurjchem-2534	378	2	,	,	PUNCT
eurjchem-2534	378	3	10	10	NUM
eurjchem-2534	378	4	,	,	PUNCT
eurjchem-2534	378	5	43–47	43–47	NUM
eurjchem-2534	378	6	.	.	PUNCT
eurjchem-2534	379	1	[	[	X
eurjchem-2534	379	2	22	22	NUM
eurjchem-2534	379	3	]	]	PUNCT
eurjchem-2534	379	4	.	.	PUNCT
eurjchem-2534	380	1	yoon	yoon	PROPN
eurjchem-2534	380	2	,	,	PUNCT
eurjchem-2534	380	3	m.	m.	PROPN
eurjchem-2534	380	4	j.	j.	PROPN
eurjchem-2534	380	5	;	;	PUNCT
eurjchem-2534	380	6	lee	lee	PROPN
eurjchem-2534	380	7	,	,	PUNCT
eurjchem-2534	380	8	a.	a.	PROPN
eurjchem-2534	380	9	r.	r.	PROPN
eurjchem-2534	380	10	;	;	PUNCT
eurjchem-2534	380	11	jeong	jeong	PROPN
eurjchem-2534	380	12	,	,	PUNCT
eurjchem-2534	380	13	s.	s.	PROPN
eurjchem-2534	380	14	a.	a.	PROPN
eurjchem-2534	380	15	;	;	PUNCT
eurjchem-2534	380	16	kim	kim	PROPN
eurjchem-2534	380	17	,	,	PUNCT
eurjchem-2534	380	18	y.-s	y.-	NOUN
eurjchem-2534	380	19	.	.	PUNCT
eurjchem-2534	380	20	;	;	PUNCT
eurjchem-2534	380	21	kim	kim	PROPN
eurjchem-2534	380	22	,	,	PUNCT
eurjchem-2534	380	23	j.	j.	PROPN
eurjchem-2534	380	24	y.	y.	PROPN
eurjchem-2534	380	25	;	;	PUNCT
eurjchem-2534	380	26	kwon	kwon	PROPN
eurjchem-2534	380	27	,	,	PUNCT
eurjchem-2534	380	28	y.-j	y.-j	PROPN
eurjchem-2534	380	29	.	.	PROPN
eurjchem-2534	380	30	;	;	PUNCT
eurjchem-2534	381	1	choi	choi	NOUN
eurjchem-2534	381	2	,	,	PUNCT
eurjchem-2534	381	3	k.	k.	PROPN
eurjchem-2534	381	4	s.	s.	PROPN
eurjchem-2534	381	5	release	release	PROPN
eurjchem-2534	381	6	of	of	ADP
eurjchem-2534	381	7	ca2	ca2	PROPN
eurjchem-2534	381	8	+	+	X
eurjchem-2534	381	9	from	from	ADP
eurjchem-2534	381	10	the	the	DET
eurjchem-2534	381	11	endoplasmic	endoplasmic	ADJ
eurjchem-2534	381	12	reticulum	reticulum	NOUN
eurjchem-2534	381	13	and	and	CCONJ
eurjchem-2534	381	14	its	its	PRON
eurjchem-2534	381	15	subsequent	subsequent	ADJ
eurjchem-2534	381	16	influx	influx	NOUN
eurjchem-2534	381	17	into	into	ADP
eurjchem-2534	381	18	mitochondria	mitochondria	NOUN
eurjchem-2534	381	19	trigger	trigger	NOUN
eurjchem-2534	381	20	celastrol	celastrol	NOUN
eurjchem-2534	381	21	-	-	PUNCT
eurjchem-2534	381	22	induced	induce	VERB
eurjchem-2534	381	23	paraptosis	paraptosis	NOUN
eurjchem-2534	381	24	in	in	ADP
eurjchem-2534	381	25	cancer	cancer	NOUN
eurjchem-2534	381	26	cells	cell	NOUN
eurjchem-2534	381	27	.	.	PUNCT
eurjchem-2534	382	1	oncotarget	oncotarget	NOUN
eurjchem-2534	382	2	2014	2014	NUM
eurjchem-2534	382	3	,	,	PUNCT
eurjchem-2534	382	4	5	5	NUM
eurjchem-2534	382	5	,	,	PUNCT
eurjchem-2534	382	6	6816–6831	6816–6831	NUM
eurjchem-2534	382	7	.	.	PUNCT
eurjchem-2534	383	1	[	[	X
eurjchem-2534	383	2	23	23	NUM
eurjchem-2534	383	3	]	]	PUNCT
eurjchem-2534	383	4	.	.	PUNCT
eurjchem-2534	384	1	de	de	X
eurjchem-2534	384	2	seabra	seabra	VERB
eurjchem-2534	384	3	rodrigues	rodrigues	PROPN
eurjchem-2534	384	4	dias	dias	PROPN
eurjchem-2534	384	5	,	,	PUNCT
eurjchem-2534	384	6	i.	i.	PROPN
eurjchem-2534	384	7	r.	r.	PROPN
eurjchem-2534	384	8	;	;	PUNCT
eurjchem-2534	384	9	mok	mok	PROPN
eurjchem-2534	384	10	,	,	PUNCT
eurjchem-2534	384	11	s.	s.	PROPN
eurjchem-2534	384	12	w.	w.	PROPN
eurjchem-2534	384	13	f.	f.	PROPN
eurjchem-2534	384	14	;	;	PUNCT
eurjchem-2534	384	15	gordillo	gordillo	PROPN
eurjchem-2534	384	16	-	-	PUNCT
eurjchem-2534	384	17	martínez	martínez	PROPN
eurjchem-2534	384	18	,	,	PUNCT
eurjchem-2534	384	19	f.	f.	PROPN
eurjchem-2534	384	20	;	;	PUNCT
eurjchem-2534	384	21	khan	khan	PROPN
eurjchem-2534	384	22	,	,	PUNCT
eurjchem-2534	384	23	i.	i.	PROPN
eurjchem-2534	384	24	;	;	PUNCT
eurjchem-2534	384	25	hsiao	hsiao	PROPN
eurjchem-2534	384	26	,	,	PUNCT
eurjchem-2534	384	27	w.	w.	PROPN
eurjchem-2534	384	28	w.	w.	PROPN
eurjchem-2534	384	29	l.	l.	PROPN
eurjchem-2534	384	30	;	;	PUNCT
eurjchem-2534	384	31	law	law	PROPN
eurjchem-2534	384	32	,	,	PUNCT
eurjchem-2534	384	33	b.	b.	PROPN
eurjchem-2534	384	34	y.	y.	PROPN
eurjchem-2534	384	35	k.	k.	PROPN
eurjchem-2534	384	36	;	;	PUNCT
eurjchem-2534	384	37	wong	wong	PROPN
eurjchem-2534	384	38	,	,	PUNCT
eurjchem-2534	384	39	v.	v.	PROPN
eurjchem-2534	384	40	k.	k.	PROPN
eurjchem-2534	384	41	w.	w.	PROPN
eurjchem-2534	384	42	;	;	PUNCT
eurjchem-2534	384	43	liu	liu	PROPN
eurjchem-2534	384	44	,	,	PUNCT
eurjchem-2534	384	45	l.	l.	PROPN
eurjchem-2534	384	46	the	the	DET
eurjchem-2534	384	47	calcium	calcium	NOUN
eurjchem-2534	384	48	-	-	PUNCT
eurjchem-2534	384	49	induced	induce	VERB
eurjchem-2534	384	50	regulation	regulation	NOUN
eurjchem-2534	384	51	in	in	ADP
eurjchem-2534	384	52	the	the	DET
eurjchem-2534	384	53	molecular	molecular	ADJ
eurjchem-2534	384	54	and	and	CCONJ
eurjchem-2534	384	55	transcriptional	transcriptional	ADJ
eurjchem-2534	384	56	circuitry	circuitry	NOUN
eurjchem-2534	384	57	of	of	ADP
eurjchem-2534	384	58	human	human	ADJ
eurjchem-2534	384	59	inflammatory	inflammatory	ADJ
eurjchem-2534	384	60	response	response	NOUN
eurjchem-2534	384	61	and	and	CCONJ
eurjchem-2534	384	62	autoimmunity	autoimmunity	NOUN
eurjchem-2534	384	63	.	.	PUNCT
eurjchem-2534	385	1	front	front	NOUN
eurjchem-2534	385	2	.	.	PUNCT
eurjchem-2534	386	1	pharmacol	pharmacol	NOUN
eurjchem-2534	386	2	.	.	PROPN
eurjchem-2534	387	1	2018	2018	NUM
eurjchem-2534	387	2	,	,	PUNCT
eurjchem-2534	387	3	8	8	NUM
eurjchem-2534	387	4	,	,	PUNCT
eurjchem-2534	387	5	962	962	NUM
eurjchem-2534	387	6	.	.	PUNCT
eurjchem-2534	388	1	[	[	X
eurjchem-2534	388	2	24	24	NUM
eurjchem-2534	388	3	]	]	PUNCT
eurjchem-2534	388	4	.	.	PUNCT
eurjchem-2534	389	1	wong	wong	PROPN
eurjchem-2534	389	2	,	,	PUNCT
eurjchem-2534	389	3	v.	v.	PROPN
eurjchem-2534	389	4	k.	k.	PROPN
eurjchem-2534	389	5	w.	w.	PROPN
eurjchem-2534	389	6	;	;	PUNCT
eurjchem-2534	389	7	qiu	qiu	PROPN
eurjchem-2534	389	8	,	,	PUNCT
eurjchem-2534	389	9	c.	c.	PROPN
eurjchem-2534	389	10	;	;	PUNCT
eurjchem-2534	389	11	xu	xu	PROPN
eurjchem-2534	389	12	,	,	PUNCT
eurjchem-2534	389	13	s.-w	s.-w	PROPN
eurjchem-2534	389	14	.	.	PUNCT
eurjchem-2534	389	15	;	;	PUNCT
eurjchem-2534	390	1	law	law	NOUN
eurjchem-2534	390	2	,	,	PUNCT
eurjchem-2534	390	3	b.	b.	PROPN
eurjchem-2534	390	4	y.	y.	PROPN
eurjchem-2534	390	5	k.	k.	PROPN
eurjchem-2534	390	6	;	;	PUNCT
eurjchem-2534	390	7	zeng	zeng	PROPN
eurjchem-2534	390	8	,	,	PUNCT
eurjchem-2534	390	9	w.	w.	PROPN
eurjchem-2534	390	10	;	;	PUNCT
eurjchem-2534	390	11	wang	wang	PROPN
eurjchem-2534	390	12	,	,	PUNCT
eurjchem-2534	390	13	h.	h.	PROPN
eurjchem-2534	390	14	;	;	PUNCT
eurjchem-2534	390	15	michelangeli	michelangeli	PROPN
eurjchem-2534	390	16	,	,	PUNCT
eurjchem-2534	390	17	f.	f.	PROPN
eurjchem-2534	390	18	;	;	PUNCT
eurjchem-2534	390	19	dias	dias	PROPN
eurjchem-2534	390	20	,	,	PUNCT
eurjchem-2534	390	21	i.	i.	PROPN
eurjchem-2534	390	22	r.	r.	PROPN
eurjchem-2534	390	23	d.	d.	PROPN
eurjchem-2534	390	24	s.	s.	PROPN
eurjchem-2534	390	25	r.	r.	PROPN
eurjchem-2534	390	26	;	;	PUNCT
eurjchem-2534	390	27	qu	qu	PROPN
eurjchem-2534	390	28	,	,	PUNCT
eurjchem-2534	390	29	y.	y.	PROPN
eurjchem-2534	390	30	q.	q.	PROPN
eurjchem-2534	390	31	;	;	PUNCT
eurjchem-2534	390	32	chan	chan	PROPN
eurjchem-2534	390	33	,	,	PUNCT
eurjchem-2534	390	34	t.	t.	PROPN
eurjchem-2534	390	35	w.	w.	PROPN
eurjchem-2534	390	36	;	;	PUNCT
eurjchem-2534	390	37	han	han	PROPN
eurjchem-2534	390	38	,	,	PUNCT
eurjchem-2534	390	39	y.	y.	PROPN
eurjchem-2534	390	40	;	;	PUNCT
eurjchem-2534	390	41	zhang	zhang	PROPN
eurjchem-2534	390	42	,	,	PUNCT
eurjchem-2534	390	43	n.	n.	PROPN
eurjchem-2534	390	44	;	;	PUNCT
eurjchem-2534	390	45	mok	mok	PROPN
eurjchem-2534	390	46	,	,	PUNCT
eurjchem-2534	390	47	s.	s.	PROPN
eurjchem-2534	390	48	w.	w.	PROPN
eurjchem-2534	390	49	f.	f.	PROPN
eurjchem-2534	390	50	;	;	PUNCT
eurjchem-2534	390	51	chen	chen	PROPN
eurjchem-2534	390	52	,	,	PUNCT
eurjchem-2534	390	53	x.	x.	PROPN
eurjchem-2534	390	54	;	;	PUNCT
eurjchem-2534	390	55	yu	yu	PROPN
eurjchem-2534	390	56	,	,	PUNCT
eurjchem-2534	390	57	l.	l.	PROPN
eurjchem-2534	390	58	;	;	PUNCT
eurjchem-2534	390	59	pan	pan	PROPN
eurjchem-2534	390	60	,	,	PUNCT
eurjchem-2534	390	61	h.	h.	PROPN
eurjchem-2534	390	62	;	;	PUNCT
eurjchem-2534	390	63	hamdoun	hamdoun	PROPN
eurjchem-2534	390	64	,	,	PUNCT
eurjchem-2534	390	65	s.	s.	PROPN
eurjchem-2534	390	66	;	;	PUNCT
eurjchem-2534	390	67	efferth	efferth	ADJ
eurjchem-2534	390	68	,	,	PUNCT
eurjchem-2534	390	69	t.	t.	PROPN
eurjchem-2534	390	70	;	;	PUNCT
eurjchem-2534	390	71	yu	yu	PROPN
eurjchem-2534	390	72	,	,	PUNCT
eurjchem-2534	390	73	w.	w.	PROPN
eurjchem-2534	390	74	j.	j.	PROPN
eurjchem-2534	390	75	;	;	PUNCT
eurjchem-2534	390	76	zhang	zhang	PROPN
eurjchem-2534	390	77	,	,	PUNCT
eurjchem-2534	390	78	w.	w.	PROPN
eurjchem-2534	390	79	;	;	PUNCT
eurjchem-2534	390	80	li	li	PROPN
eurjchem-2534	390	81	,	,	PUNCT
eurjchem-2534	390	82	z.	z.	PROPN
eurjchem-2534	390	83	;	;	PUNCT
eurjchem-2534	390	84	xie	xie	PROPN
eurjchem-2534	390	85	,	,	PUNCT
eurjchem-2534	390	86	y.	y.	PROPN
eurjchem-2534	390	87	;	;	PUNCT
eurjchem-2534	390	88	luo	luo	PROPN
eurjchem-2534	390	89	,	,	PUNCT
eurjchem-2534	390	90	r.	r.	PROPN
eurjchem-2534	390	91	;	;	PUNCT
eurjchem-2534	390	92	jiang	jiang	PROPN
eurjchem-2534	390	93	,	,	PUNCT
eurjchem-2534	390	94	q.	q.	PROPN
eurjchem-2534	390	95	;	;	PUNCT
eurjchem-2534	390	96	liu	liu	PROPN
eurjchem-2534	390	97	,	,	PUNCT
eurjchem-2534	390	98	l.	l.	PROPN
eurjchem-2534	390	99	ca2	ca2	PROPN
eurjchem-2534	390	100	+	+	PROPN
eurjchem-2534	390	101	signalling	signal	VERB
eurjchem-2534	390	102	plays	play	VERB
eurjchem-2534	390	103	a	a	DET
eurjchem-2534	390	104	role	role	NOUN
eurjchem-2534	390	105	in	in	ADP
eurjchem-2534	390	106	celastrol	celastrol	NOUN
eurjchem-2534	390	107	-	-	PUNCT
eurjchem-2534	390	108	mediated	mediate	VERB
eurjchem-2534	390	109	suppression	suppression	NOUN
eurjchem-2534	390	110	of	of	ADP
eurjchem-2534	390	111	synovial	synovial	ADJ
eurjchem-2534	390	112	fibroblasts	fibroblast	NOUN
eurjchem-2534	390	113	of	of	ADP
eurjchem-2534	390	114	rheumatoid	rheumatoid	VERB
eurjchem-2534	390	115	arthritis	arthritis	NOUN
eurjchem-2534	390	116	patients	patient	NOUN
eurjchem-2534	390	117	and	and	CCONJ
eurjchem-2534	390	118	experimental	experimental	ADJ
eurjchem-2534	390	119	arthritis	arthritis	NOUN
eurjchem-2534	390	120	in	in	ADP
eurjchem-2534	390	121	rats	rat	NOUN
eurjchem-2534	390	122	.	.	PUNCT
eurjchem-2534	391	1	br	br	X
eurjchem-2534	391	2	.	.	PUNCT
eurjchem-2534	392	1	j.	j.	PROPN
eurjchem-2534	392	2	pharmacol	pharmacol	PROPN
eurjchem-2534	392	3	.	.	PROPN
eurjchem-2534	393	1	2019	2019	NUM
eurjchem-2534	393	2	,	,	PUNCT
eurjchem-2534	393	3	176	176	NUM
eurjchem-2534	393	4	,	,	PUNCT
eurjchem-2534	393	5	2922–2944	2922–2944	NUM
eurjchem-2534	393	6	.	.	PUNCT
eurjchem-2534	394	1	[	[	X
eurjchem-2534	394	2	25	25	NUM
eurjchem-2534	394	3	]	]	PUNCT
eurjchem-2534	394	4	.	.	PUNCT
eurjchem-2534	395	1	bai	bai	PROPN
eurjchem-2534	395	2	,	,	PUNCT
eurjchem-2534	395	3	x.	x.	NOUN
eurjchem-2534	395	4	;	;	PUNCT
eurjchem-2534	395	5	fu	fu	NOUN
eurjchem-2534	395	6	,	,	PUNCT
eurjchem-2534	395	7	r.-j	r.-j	PROPN
eurjchem-2534	395	8	.	.	PUNCT
eurjchem-2534	395	9	;	;	PUNCT
eurjchem-2534	395	10	zhang	zhang	PROPN
eurjchem-2534	395	11	,	,	PUNCT
eurjchem-2534	395	12	s.	s.	PROPN
eurjchem-2534	395	13	;	;	PUNCT
eurjchem-2534	395	14	yue	yue	PROPN
eurjchem-2534	395	15	,	,	PUNCT
eurjchem-2534	395	16	s.-j	s.-j	PROPN
eurjchem-2534	395	17	.	.	PUNCT
eurjchem-2534	395	18	;	;	PUNCT
eurjchem-2534	396	1	chen	chen	PROPN
eurjchem-2534	396	2	,	,	PUNCT
eurjchem-2534	396	3	y.-y	y.-y	PROPN
eurjchem-2534	396	4	.	.	PUNCT
eurjchem-2534	396	5	;	;	PUNCT
eurjchem-2534	396	6	xu	xu	INTJ
eurjchem-2534	396	7	,	,	PUNCT
eurjchem-2534	396	8	d.-q	d.-q	PROPN
eurjchem-2534	396	9	.	.	PUNCT
eurjchem-2534	396	10	;	;	PUNCT
eurjchem-2534	396	11	tang	tang	PROPN
eurjchem-2534	396	12	,	,	PUNCT
eurjchem-2534	396	13	y.-p	y.-p	PROPN
eurjchem-2534	396	14	.	.	PUNCT
eurjchem-2534	397	1	potential	potential	ADJ
eurjchem-2534	397	2	medicinal	medicinal	ADJ
eurjchem-2534	397	3	value	value	NOUN
eurjchem-2534	397	4	of	of	ADP
eurjchem-2534	397	5	celastrol	celastrol	NOUN
eurjchem-2534	397	6	and	and	CCONJ
eurjchem-2534	397	7	its	its	PRON
eurjchem-2534	397	8	synthesized	synthesize	VERB
eurjchem-2534	397	9	analogues	analogue	NOUN
eurjchem-2534	397	10	for	for	ADP
eurjchem-2534	397	11	central	central	ADJ
eurjchem-2534	397	12	nervous	nervous	ADJ
eurjchem-2534	397	13	system	system	NOUN
eurjchem-2534	397	14	diseases	disease	NOUN
eurjchem-2534	397	15	.	.	PUNCT
eurjchem-2534	397	16	biomed	biome	VERB
eurjchem-2534	397	17	.	.	PUNCT
eurjchem-2534	398	1	pharmacother	pharmacother	ADJ
eurjchem-2534	398	2	.	.	PUNCT
eurjchem-2534	399	1	2021	2021	NUM
eurjchem-2534	399	2	,	,	PUNCT
eurjchem-2534	399	3	139	139	NUM
eurjchem-2534	399	4	,	,	PUNCT
eurjchem-2534	399	5	111551	111551	NUM
eurjchem-2534	399	6	.	.	PUNCT
eurjchem-2534	400	1	[	[	X
eurjchem-2534	400	2	26	26	NUM
eurjchem-2534	400	3	]	]	PUNCT
eurjchem-2534	400	4	.	.	PUNCT
eurjchem-2534	401	1	hou	hou	PROPN
eurjchem-2534	401	2	,	,	PUNCT
eurjchem-2534	401	3	w.	w.	PROPN
eurjchem-2534	401	4	;	;	PUNCT
eurjchem-2534	401	5	liu	liu	PROPN
eurjchem-2534	401	6	,	,	PUNCT
eurjchem-2534	401	7	b.	b.	PROPN
eurjchem-2534	401	8	;	;	PUNCT
eurjchem-2534	401	9	xu	xu	PROPN
eurjchem-2534	401	10	,	,	PUNCT
eurjchem-2534	401	11	h.	h.	PROPN
eurjchem-2534	401	12	celastrol	celastrol	PROPN
eurjchem-2534	401	13	:	:	PUNCT
eurjchem-2534	401	14	progresses	progress	NOUN
eurjchem-2534	401	15	in	in	ADP
eurjchem-2534	401	16	structuremodifications	structuremodification	NOUN
eurjchem-2534	401	17	,	,	PUNCT
eurjchem-2534	401	18	structure	structure	NOUN
eurjchem-2534	401	19	-	-	PUNCT
eurjchem-2534	401	20	activity	activity	NOUN
eurjchem-2534	401	21	relationships	relationship	NOUN
eurjchem-2534	401	22	,	,	PUNCT
eurjchem-2534	401	23	pharmacology	pharmacology	NOUN
eurjchem-2534	401	24	and	and	CCONJ
eurjchem-2534	401	25	toxicology	toxicology	NOUN
eurjchem-2534	401	26	.	.	PUNCT
eurjchem-2534	402	1	eur	eur	PROPN
eurjchem-2534	402	2	.	.	PUNCT
eurjchem-2534	403	1	j.	j.	PROPN
eurjchem-2534	403	2	med	med	PROPN
eurjchem-2534	403	3	.	.	PROPN
eurjchem-2534	403	4	chem	chem	PROPN
eurjchem-2534	403	5	.	.	PUNCT
eurjchem-2534	404	1	2020	2020	NUM
eurjchem-2534	404	2	,	,	PUNCT
eurjchem-2534	404	3	189	189	NUM
eurjchem-2534	404	4	,	,	PUNCT
eurjchem-2534	404	5	112081	112081	NUM
eurjchem-2534	404	6	.	.	PUNCT
eurjchem-2534	405	1	[	[	X
eurjchem-2534	405	2	27	27	NUM
eurjchem-2534	405	3	]	]	PUNCT
eurjchem-2534	405	4	.	.	PUNCT
eurjchem-2534	406	1	lu	lu	PROPN
eurjchem-2534	406	2	,	,	PUNCT
eurjchem-2534	406	3	y.	y.	PROPN
eurjchem-2534	406	4	;	;	PUNCT
eurjchem-2534	406	5	liu	liu	PROPN
eurjchem-2534	406	6	,	,	PUNCT
eurjchem-2534	406	7	y.	y.	PROPN
eurjchem-2534	406	8	;	;	PUNCT
eurjchem-2534	406	9	zhou	zhou	PROPN
eurjchem-2534	406	10	,	,	PUNCT
eurjchem-2534	406	11	j.	j.	PROPN
eurjchem-2534	406	12	;	;	PUNCT
eurjchem-2534	406	13	li	li	PROPN
eurjchem-2534	406	14	,	,	PUNCT
eurjchem-2534	406	15	d.	d.	PROPN
eurjchem-2534	406	16	;	;	PUNCT
eurjchem-2534	406	17	gao	gao	PROPN
eurjchem-2534	406	18	,	,	PUNCT
eurjchem-2534	406	19	w.	w.	PROPN
eurjchem-2534	406	20	biosynthesis	biosynthesis	NOUN
eurjchem-2534	406	21	,	,	PUNCT
eurjchem-2534	406	22	total	total	ADJ
eurjchem-2534	406	23	synthesis	synthesis	NOUN
eurjchem-2534	406	24	,	,	PUNCT
eurjchem-2534	406	25	structural	structural	ADJ
eurjchem-2534	406	26	modifications	modification	NOUN
eurjchem-2534	406	27	,	,	PUNCT
eurjchem-2534	406	28	bioactivity	bioactivity	NOUN
eurjchem-2534	406	29	,	,	PUNCT
eurjchem-2534	406	30	and	and	CCONJ
eurjchem-2534	406	31	mechanism	mechanism	NOUN
eurjchem-2534	406	32	of	of	ADP
eurjchem-2534	406	33	action	action	NOUN
eurjchem-2534	406	34	of	of	ADP
eurjchem-2534	406	35	the	the	DET
eurjchem-2534	406	36	quinone	quinone	NOUN
eurjchem-2534	406	37	-	-	PUNCT
eurjchem-2534	406	38	methide	methide	NOUN
eurjchem-2534	406	39	triterpenoid	triterpenoid	NOUN
eurjchem-2534	406	40	celastrol	celastrol	NOUN
eurjchem-2534	406	41	.	.	PUNCT
eurjchem-2534	407	1	med	med	PROPN
eurjchem-2534	407	2	.	.	PUNCT
eurjchem-2534	408	1	res	re	NOUN
eurjchem-2534	408	2	.	.	PUNCT
eurjchem-2534	409	1	rev	rev	PROPN
eurjchem-2534	409	2	.	.	PROPN
eurjchem-2534	409	3	2021	2021	NUM
eurjchem-2534	409	4	,	,	PUNCT
eurjchem-2534	409	5	41	41	NUM
eurjchem-2534	409	6	,	,	PUNCT
eurjchem-2534	409	7	1022–1060	1022–1060	NUM
eurjchem-2534	409	8	.	.	PUNCT
eurjchem-2534	410	1	[	[	X
eurjchem-2534	410	2	28	28	NUM
eurjchem-2534	410	3	]	]	PUNCT
eurjchem-2534	410	4	.	.	PUNCT
eurjchem-2534	411	1	xie	xie	PROPN
eurjchem-2534	411	2	,	,	PUNCT
eurjchem-2534	411	3	y.	y.	PROPN
eurjchem-2534	411	4	;	;	PUNCT
eurjchem-2534	411	5	kuan	kuan	PROPN
eurjchem-2534	411	6	,	,	PUNCT
eurjchem-2534	411	7	h.	h.	PROPN
eurjchem-2534	411	8	;	;	PUNCT
eurjchem-2534	411	9	wei	wei	PROPN
eurjchem-2534	411	10	,	,	PUNCT
eurjchem-2534	411	11	q.	q.	PROPN
eurjchem-2534	411	12	;	;	PUNCT
eurjchem-2534	411	13	gianoncelli	gianoncelli	PROPN
eurjchem-2534	411	14	,	,	PUNCT
eurjchem-2534	411	15	a.	a.	NOUN
eurjchem-2534	411	16	;	;	PUNCT
eurjchem-2534	411	17	ribaudo	ribaudo	NOUN
eurjchem-2534	411	18	,	,	PUNCT
eurjchem-2534	411	19	g.	g.	PROPN
eurjchem-2534	411	20	;	;	PUNCT
eurjchem-2534	411	21	coghi	coghi	PROPN
eurjchem-2534	411	22	,	,	PUNCT
eurjchem-2534	411	23	p.	p.	NOUN
eurjchem-2534	411	24	(	(	PUNCT
eurjchem-2534	411	25	2r,4as,6as,12br,14as,14br)10	2r,4as,6as,12br,14as,14br)10	NUM
eurjchem-2534	411	26	-	-	PUNCT
eurjchem-2534	411	27	hydroxy	hydroxy	VERB
eurjchem-2534	411	28	-	-	PUNCT
eurjchem-2534	411	29	n-(4-((6	n-(4-((6	NOUN
eurjchem-2534	411	30	-	-	PUNCT
eurjchem-2534	411	31	methoxy	methoxy	ADJ
eurjchem-2534	411	32	quinolin-8	quinolin-8	PROPN
eurjchem-2534	411	33	-	-	PUNCT
eurjchem-2534	411	34	yl)amino)pentyl)-2,4a,6a,9,12b,14a	yl)amino)pentyl)-2,4a,6a,9,12b,14a	NOUN
eurjchem-2534	411	35	-	-	PUNCT
eurjchem-2534	411	36	hexamethyl-11	hexamethyl-11	PROPN
eurjchem-2534	411	37	-	-	PUNCT
eurjchem-2534	411	38	oxo1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b	oxo1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b	NOUN
eurjchem-2534	411	39	-	-	PUNCT
eurjchem-2534	411	40	tetradecahydropicene-2carboxamide	tetradecahydropicene-2carboxamide	NOUN
eurjchem-2534	411	41	.	.	PUNCT
eurjchem-2534	412	1	molbank	molbank	PROPN
eurjchem-2534	412	2	2023	2023	NUM
eurjchem-2534	412	3	,	,	PUNCT
eurjchem-2534	412	4	2023	2023	NUM
eurjchem-2534	412	5	,	,	PUNCT
eurjchem-2534	412	6	m1716	m1716	PROPN
eurjchem-2534	412	7	.	.	PUNCT
eurjchem-2534	413	1	[	[	X
eurjchem-2534	413	2	29	29	NUM
eurjchem-2534	413	3	]	]	PUNCT
eurjchem-2534	413	4	.	.	PUNCT
eurjchem-2534	414	1	klaić	klaić	PROPN
eurjchem-2534	414	2	,	,	PUNCT
eurjchem-2534	414	3	l.	l.	PROPN
eurjchem-2534	414	4	;	;	PUNCT
eurjchem-2534	414	5	morimoto	morimoto	PROPN
eurjchem-2534	414	6	,	,	PUNCT
eurjchem-2534	414	7	r.	r.	PROPN
eurjchem-2534	414	8	i.	i.	PROPN
eurjchem-2534	414	9	;	;	PUNCT
eurjchem-2534	414	10	silverman	silverman	PROPN
eurjchem-2534	414	11	,	,	PUNCT
eurjchem-2534	414	12	r.	r.	PROPN
eurjchem-2534	414	13	b.	b.	PROPN
eurjchem-2534	414	14	celastrol	celastrol	PROPN
eurjchem-2534	414	15	analogues	analogue	NOUN
eurjchem-2534	414	16	as	as	ADP
eurjchem-2534	414	17	inducers	inducer	NOUN
eurjchem-2534	414	18	of	of	ADP
eurjchem-2534	414	19	the	the	DET
eurjchem-2534	414	20	heat	heat	NOUN
eurjchem-2534	414	21	shock	shock	NOUN
eurjchem-2534	414	22	response	response	NOUN
eurjchem-2534	414	23	.	.	PUNCT
eurjchem-2534	415	1	design	design	NOUN
eurjchem-2534	415	2	and	and	CCONJ
eurjchem-2534	415	3	synthesis	synthesis	NOUN
eurjchem-2534	415	4	of	of	ADP
eurjchem-2534	415	5	affinity	affinity	NOUN
eurjchem-2534	415	6	probes	probe	NOUN
eurjchem-2534	415	7	for	for	ADP
eurjchem-2534	415	8	the	the	DET
eurjchem-2534	415	9	identification	identification	NOUN
eurjchem-2534	415	10	of	of	ADP
eurjchem-2534	415	11	protein	protein	NOUN
eurjchem-2534	415	12	targets	target	NOUN
eurjchem-2534	415	13	.	.	PUNCT
eurjchem-2534	416	1	acs	acs	PROPN
eurjchem-2534	416	2	chem	chem	NOUN
eurjchem-2534	416	3	.	.	PUNCT
eurjchem-2534	417	1	biol	biol	PROPN
eurjchem-2534	417	2	.	.	PUNCT
eurjchem-2534	418	1	2012	2012	NUM
eurjchem-2534	418	2	,	,	PUNCT
eurjchem-2534	418	3	7	7	NUM
eurjchem-2534	418	4	,	,	PUNCT
eurjchem-2534	418	5	928–937	928–937	NUM
eurjchem-2534	418	6	.	.	PUNCT
eurjchem-2534	419	1	[	[	X
eurjchem-2534	419	2	30	30	NUM
eurjchem-2534	419	3	]	]	SYM
eurjchem-2534	419	4	.	.	PUNCT
eurjchem-2534	420	1	shan	shan	PROPN
eurjchem-2534	420	2	,	,	PUNCT
eurjchem-2534	420	3	w.-g	w.-g	PROPN
eurjchem-2534	420	4	.	.	PUNCT
eurjchem-2534	421	1	;	;	PUNCT
eurjchem-2534	421	2	wang	wang	PROPN
eurjchem-2534	421	3	,	,	PUNCT
eurjchem-2534	421	4	h.-g	h.-g	PROPN
eurjchem-2534	421	5	.	.	PUNCT
eurjchem-2534	421	6	;	;	PUNCT
eurjchem-2534	421	7	chen	chen	PROPN
eurjchem-2534	421	8	,	,	PUNCT
eurjchem-2534	421	9	y.	y.	PROPN
eurjchem-2534	421	10	;	;	PUNCT
eurjchem-2534	421	11	wu	wu	PROPN
eurjchem-2534	421	12	,	,	PUNCT
eurjchem-2534	421	13	r.	r.	PROPN
eurjchem-2534	421	14	;	;	PUNCT
eurjchem-2534	421	15	wen	wen	PROPN
eurjchem-2534	421	16	,	,	PUNCT
eurjchem-2534	421	17	y.-t	y.-t	NOUN
eurjchem-2534	421	18	.	.	PUNCT
eurjchem-2534	421	19	;	;	PUNCT
eurjchem-2534	421	20	zhang	zhang	PROPN
eurjchem-2534	421	21	,	,	PUNCT
eurjchem-2534	421	22	l.-w	l.-w	PROPN
eurjchem-2534	421	23	.	.	PUNCT
eurjchem-2534	421	24	;	;	PUNCT
eurjchem-2534	421	25	ying	ying	PROPN
eurjchem-2534	421	26	,	,	PUNCT
eurjchem-2534	421	27	y.-m	y.-m	PROPN
eurjchem-2534	421	28	.	.	PUNCT
eurjchem-2534	421	29	;	;	PUNCT
eurjchem-2534	421	30	wang	wang	PROPN
eurjchem-2534	421	31	,	,	PUNCT
eurjchem-2534	421	32	j.-w	j.-w	PROPN
eurjchem-2534	421	33	.	.	PUNCT
eurjchem-2534	421	34	;	;	PUNCT
eurjchem-2534	421	35	zhan	zhan	PROPN
eurjchem-2534	421	36	,	,	PUNCT
eurjchem-2534	421	37	z.-j	z.-j	PROPN
eurjchem-2534	421	38	.	.	PUNCT
eurjchem-2534	422	1	synthesis	synthesis	NOUN
eurjchem-2534	422	2	of	of	ADP
eurjchem-2534	422	3	3and	3and	NUM
eurjchem-2534	422	4	29	29	NUM
eurjchem-2534	422	5	-	-	PUNCT
eurjchem-2534	422	6	substituted	substitute	VERB
eurjchem-2534	422	7	celastrol	celastrol	NOUN
eurjchem-2534	422	8	derivatives	derivative	NOUN
eurjchem-2534	422	9	and	and	CCONJ
eurjchem-2534	422	10	structure	structure	NOUN
eurjchem-2534	422	11	-	-	PUNCT
eurjchem-2534	422	12	activity	activity	NOUN
eurjchem-2534	422	13	relationship	relationship	NOUN
eurjchem-2534	422	14	studies	study	NOUN
eurjchem-2534	422	15	of	of	ADP
eurjchem-2534	422	16	their	their	PRON
eurjchem-2534	422	17	cytotoxic	cytotoxic	ADJ
eurjchem-2534	422	18	activities	activity	NOUN
eurjchem-2534	422	19	.	.	PUNCT
eurjchem-2534	423	1	bioorg	bioorg	VERB
eurjchem-2534	423	2	.	.	PUNCT
eurjchem-2534	424	1	med	med	PROPN
eurjchem-2534	424	2	.	.	PROPN
eurjchem-2534	424	3	chem	chem	PROPN
eurjchem-2534	424	4	.	.	PUNCT
eurjchem-2534	425	1	lett	lett	PROPN
eurjchem-2534	425	2	.	.	PROPN
eurjchem-2534	426	1	2017	2017	NUM
eurjchem-2534	426	2	,	,	PUNCT
eurjchem-2534	426	3	27	27	NUM
eurjchem-2534	426	4	,	,	PUNCT
eurjchem-2534	426	5	3450	3450	NUM
eurjchem-2534	426	6	–	–	PUNCT
eurjchem-2534	426	7	3453	3453	NUM
eurjchem-2534	426	8	.	.	PUNCT
eurjchem-2534	427	1	[	[	X
eurjchem-2534	427	2	31	31	NUM
eurjchem-2534	427	3	]	]	PUNCT
eurjchem-2534	427	4	.	.	PUNCT
eurjchem-2534	428	1	pang	pang	NOUN
eurjchem-2534	428	2	,	,	PUNCT
eurjchem-2534	428	3	c.	c.	PROPN
eurjchem-2534	428	4	;	;	PUNCT
eurjchem-2534	428	5	luo	luo	PROPN
eurjchem-2534	428	6	,	,	PUNCT
eurjchem-2534	428	7	j.	j.	PROPN
eurjchem-2534	428	8	;	;	PUNCT
eurjchem-2534	428	9	liu	liu	PROPN
eurjchem-2534	428	10	,	,	PUNCT
eurjchem-2534	428	11	c.	c.	PROPN
eurjchem-2534	428	12	;	;	PUNCT
eurjchem-2534	428	13	wu	wu	PROPN
eurjchem-2534	428	14	,	,	PUNCT
eurjchem-2534	428	15	x.	x.	PROPN
eurjchem-2534	428	16	;	;	PUNCT
eurjchem-2534	428	17	wang	wang	PROPN
eurjchem-2534	428	18	,	,	PUNCT
eurjchem-2534	428	19	d.	d.	NOUN
eurjchem-2534	428	20	synthesis	synthesis	NOUN
eurjchem-2534	428	21	and	and	CCONJ
eurjchem-2534	428	22	biological	biological	ADJ
eurjchem-2534	428	23	evaluation	evaluation	NOUN
eurjchem-2534	428	24	of	of	ADP
eurjchem-2534	428	25	a	a	DET
eurjchem-2534	428	26	series	series	NOUN
eurjchem-2534	428	27	of	of	ADP
eurjchem-2534	428	28	novel	novel	ADJ
eurjchem-2534	428	29	celastrol	celastrol	NOUN
eurjchem-2534	428	30	derivatives	derivative	NOUN
eurjchem-2534	428	31	with	with	ADP
eurjchem-2534	428	32	amino	amino	NOUN
eurjchem-2534	428	33	acid	acid	NOUN
eurjchem-2534	428	34	chain	chain	NOUN
eurjchem-2534	428	35	.	.	PUNCT
eurjchem-2534	429	1	chem	chem	NOUN
eurjchem-2534	429	2	.	.	PUNCT
eurjchem-2534	430	1	biodivers	biodiver	NOUN
eurjchem-2534	430	2	.	.	PUNCT
eurjchem-2534	431	1	2018	2018	NUM
eurjchem-2534	431	2	,	,	PUNCT
eurjchem-2534	431	3	15	15	NUM
eurjchem-2534	431	4	,	,	PUNCT
eurjchem-2534	431	5	e1800059	e1800059	X
eurjchem-2534	431	6	.	.	PUNCT
eurjchem-2534	432	1	[	[	X
eurjchem-2534	432	2	32	32	NUM
eurjchem-2534	432	3	]	]	PUNCT
eurjchem-2534	432	4	.	.	PUNCT
eurjchem-2534	433	1	coghi	coghi	PROPN
eurjchem-2534	433	2	,	,	PUNCT
eurjchem-2534	433	3	p.	p.	NOUN
eurjchem-2534	433	4	;	;	PUNCT
eurjchem-2534	433	5	ng	ng	PROPN
eurjchem-2534	433	6	,	,	PUNCT
eurjchem-2534	433	7	j.	j.	PROPN
eurjchem-2534	433	8	p.	p.	PROPN
eurjchem-2534	433	9	l.	l.	PROPN
eurjchem-2534	433	10	;	;	PUNCT
eurjchem-2534	433	11	kadioglu	kadioglu	PROPN
eurjchem-2534	433	12	,	,	PUNCT
eurjchem-2534	433	13	o.	o.	PROPN
eurjchem-2534	433	14	;	;	PUNCT
eurjchem-2534	433	15	law	law	NOUN
eurjchem-2534	433	16	,	,	PUNCT
eurjchem-2534	433	17	b.	b.	PROPN
eurjchem-2534	433	18	y.	y.	PROPN
eurjchem-2534	433	19	k.	k.	PROPN
eurjchem-2534	433	20	;	;	PUNCT
eurjchem-2534	433	21	qiu	qiu	PROPN
eurjchem-2534	433	22	,	,	PUNCT
eurjchem-2534	433	23	a.	a.	PROPN
eurjchem-2534	433	24	c.	c.	PROPN
eurjchem-2534	433	25	;	;	PUNCT
eurjchem-2534	433	26	saeed	saeed	PROPN
eurjchem-2534	433	27	,	,	PUNCT
eurjchem-2534	433	28	m.	m.	PROPN
eurjchem-2534	433	29	e.	e.	PROPN
eurjchem-2534	433	30	m.	m.	PROPN
eurjchem-2534	433	31	;	;	PUNCT
eurjchem-2534	433	32	chen	chen	PROPN
eurjchem-2534	433	33	,	,	PUNCT
eurjchem-2534	433	34	x.	x.	NOUN
eurjchem-2534	433	35	;	;	PUNCT
eurjchem-2534	433	36	ip	ip	PROPN
eurjchem-2534	433	37	,	,	PUNCT
eurjchem-2534	433	38	c.	c.	PROPN
eurjchem-2534	433	39	k.	k.	PROPN
eurjchem-2534	433	40	;	;	PUNCT
eurjchem-2534	433	41	efferth	efferth	ADJ
eurjchem-2534	433	42	,	,	PUNCT
eurjchem-2534	433	43	t.	t.	PROPN
eurjchem-2534	433	44	;	;	PUNCT
eurjchem-2534	433	45	liu	liu	PROPN
eurjchem-2534	433	46	,	,	PUNCT
eurjchem-2534	433	47	l.	l.	PROPN
eurjchem-2534	433	48	;	;	PUNCT
eurjchem-2534	433	49	wong	wong	PROPN
eurjchem-2534	433	50	,	,	PUNCT
eurjchem-2534	433	51	v.	v.	PROPN
eurjchem-2534	433	52	k.	k.	PROPN
eurjchem-2534	433	53	w.	w.	PROPN
eurjchem-2534	433	54	synthesis	synthesis	PROPN
eurjchem-2534	433	55	,	,	PUNCT
eurjchem-2534	433	56	computational	computational	ADJ
eurjchem-2534	433	57	docking	docking	NOUN
eurjchem-2534	433	58	and	and	CCONJ
eurjchem-2534	433	59	biological	biological	ADJ
eurjchem-2534	433	60	evaluation	evaluation	NOUN
eurjchem-2534	433	61	of	of	ADP
eurjchem-2534	433	62	celastrol	celastrol	NOUN
eurjchem-2534	433	63	derivatives	derivative	NOUN
eurjchem-2534	433	64	as	as	ADP
eurjchem-2534	433	65	dual	dual	ADJ
eurjchem-2534	433	66	inhibitors	inhibitor	NOUN
eurjchem-2534	433	67	of	of	ADP
eurjchem-2534	433	68	serca	serca	NOUN
eurjchem-2534	433	69	and	and	CCONJ
eurjchem-2534	433	70	p	p	NOUN
eurjchem-2534	433	71	-	-	PUNCT
eurjchem-2534	433	72	glycoprotein	glycoprotein	NOUN
eurjchem-2534	433	73	in	in	ADP
eurjchem-2534	433	74	cancer	cancer	NOUN
eurjchem-2534	433	75	therapy	therapy	NOUN
eurjchem-2534	433	76	.	.	PUNCT
eurjchem-2534	434	1	eur	eur	PROPN
eurjchem-2534	434	2	.	.	PUNCT
eurjchem-2534	435	1	j.	j.	PROPN
eurjchem-2534	435	2	med	med	PROPN
eurjchem-2534	435	3	.	.	PROPN
eurjchem-2534	435	4	chem	chem	PROPN
eurjchem-2534	435	5	.	.	PUNCT
eurjchem-2534	436	1	2021	2021	NUM
eurjchem-2534	436	2	,	,	PUNCT
eurjchem-2534	436	3	224	224	NUM
eurjchem-2534	436	4	,	,	PUNCT
eurjchem-2534	436	5	113676	113676	NUM
eurjchem-2534	436	6	.	.	PUNCT
eurjchem-2534	437	1	[	[	X
eurjchem-2534	437	2	33	33	NUM
eurjchem-2534	437	3	]	]	SYM
eurjchem-2534	437	4	.	.	PUNCT
eurjchem-2534	437	5	tang	tang	PROPN
eurjchem-2534	437	6	,	,	PUNCT
eurjchem-2534	437	7	k.	k.	PROPN
eurjchem-2534	437	8	;	;	PUNCT
eurjchem-2534	437	9	huang	huang	PROPN
eurjchem-2534	437	10	,	,	PUNCT
eurjchem-2534	437	11	q.	q.	PROPN
eurjchem-2534	437	12	;	;	PUNCT
eurjchem-2534	437	13	zeng	zeng	PROPN
eurjchem-2534	437	14	,	,	PUNCT
eurjchem-2534	437	15	j.	j.	PROPN
eurjchem-2534	437	16	;	;	PUNCT
eurjchem-2534	437	17	wu	wu	PROPN
eurjchem-2534	437	18	,	,	PUNCT
eurjchem-2534	437	19	g.	g.	PROPN
eurjchem-2534	437	20	;	;	PUNCT
eurjchem-2534	437	21	huang	huang	PROPN
eurjchem-2534	437	22	,	,	PUNCT
eurjchem-2534	437	23	j.	j.	PROPN
eurjchem-2534	437	24	;	;	PUNCT
eurjchem-2534	437	25	pan	pan	PROPN
eurjchem-2534	437	26	,	,	PUNCT
eurjchem-2534	437	27	j.	j.	PROPN
eurjchem-2534	437	28	;	;	PUNCT
eurjchem-2534	437	29	lu	lu	PROPN
eurjchem-2534	437	30	,	,	PUNCT
eurjchem-2534	437	31	w.	w.	PROPN
eurjchem-2534	437	32	design	design	PROPN
eurjchem-2534	437	33	,	,	PUNCT
eurjchem-2534	437	34	synthesis	synthesis	NOUN
eurjchem-2534	437	35	and	and	CCONJ
eurjchem-2534	437	36	biological	biological	ADJ
eurjchem-2534	437	37	evaluation	evaluation	NOUN
eurjchem-2534	437	38	of	of	ADP
eurjchem-2534	437	39	c(6)-modified	c(6)-modifie	VERB
eurjchem-2534	437	40	celastrol	celastrol	NOUN
eurjchem-2534	437	41	derivatives	derivative	NOUN
eurjchem-2534	437	42	as	as	ADP
eurjchem-2534	437	43	potential	potential	ADJ
eurjchem-2534	437	44	antitumor	antitumor	PROPN
eurjchem-2534	437	45	agents	agent	NOUN
eurjchem-2534	437	46	.	.	PUNCT
eurjchem-2534	438	1	molecules	molecule	NOUN
eurjchem-2534	438	2	2014	2014	NUM
eurjchem-2534	438	3	,	,	PUNCT
eurjchem-2534	438	4	19	19	NUM
eurjchem-2534	438	5	,	,	PUNCT
eurjchem-2534	438	6	10177	10177	NUM
eurjchem-2534	438	7	–	–	PUNCT
eurjchem-2534	438	8	10188	10188	NUM
eurjchem-2534	438	9	.	.	PUNCT
eurjchem-2534	439	1	[	[	X
eurjchem-2534	439	2	34	34	NUM
eurjchem-2534	439	3	]	]	PUNCT
eurjchem-2534	439	4	.	.	PUNCT
eurjchem-2534	440	1	zhu	zhu	PROPN
eurjchem-2534	440	2	,	,	PUNCT
eurjchem-2534	440	3	y.	y.	PROPN
eurjchem-2534	440	4	;	;	PUNCT
eurjchem-2534	440	5	chen	chen	PROPN
eurjchem-2534	440	6	,	,	PUNCT
eurjchem-2534	440	7	z.	z.	PROPN
eurjchem-2534	440	8	;	;	PUNCT
eurjchem-2534	440	9	huang	huang	PROPN
eurjchem-2534	440	10	,	,	PUNCT
eurjchem-2534	440	11	z.	z.	PROPN
eurjchem-2534	440	12	;	;	PUNCT
eurjchem-2534	440	13	yan	yan	PROPN
eurjchem-2534	440	14	,	,	PUNCT
eurjchem-2534	440	15	s.	s.	PROPN
eurjchem-2534	440	16	;	;	PUNCT
eurjchem-2534	440	17	li	li	PROPN
eurjchem-2534	440	18	,	,	PUNCT
eurjchem-2534	440	19	z.	z.	PROPN
eurjchem-2534	440	20	;	;	PUNCT
eurjchem-2534	440	21	zhou	zhou	PROPN
eurjchem-2534	440	22	,	,	PUNCT
eurjchem-2534	440	23	h.	h.	PROPN
eurjchem-2534	440	24	;	;	PUNCT
eurjchem-2534	440	25	zhang	zhang	PROPN
eurjchem-2534	440	26	,	,	PUNCT
eurjchem-2534	440	27	x.	x.	PROPN
eurjchem-2534	440	28	;	;	PUNCT
eurjchem-2534	440	29	su	su	PROPN
eurjchem-2534	440	30	,	,	PUNCT
eurjchem-2534	440	31	y.	y.	PROPN
eurjchem-2534	440	32	;	;	PUNCT
eurjchem-2534	440	33	zeng	zeng	PROPN
eurjchem-2534	440	34	,	,	PUNCT
eurjchem-2534	440	35	z.	z.	PROPN
eurjchem-2534	440	36	alcl3·6h2o	alcl3·6h2o	PROPN
eurjchem-2534	440	37	-	-	PUNCT
eurjchem-2534	440	38	catalyzed	catalyze	VERB
eurjchem-2534	440	39	friedel	friedel	PROPN
eurjchem-2534	440	40	-	-	PUNCT
eurjchem-2534	440	41	crafts	craft	NOUN
eurjchem-2534	440	42	alkylation	alkylation	NOUN
eurjchem-2534	440	43	of	of	ADP
eurjchem-2534	440	44	indoles	indole	NOUN
eurjchem-2534	440	45	by	by	ADP
eurjchem-2534	440	46	the	the	DET
eurjchem-2534	440	47	para	para	NOUN
eurjchem-2534	440	48	-	-	PUNCT
eurjchem-2534	440	49	quinone	quinone	NOUN
eurjchem-2534	440	50	methide	methide	NOUN
eurjchem-2534	440	51	moiety	moiety	NOUN
eurjchem-2534	440	52	of	of	ADP
eurjchem-2534	440	53	celastrol	celastrol	NOUN
eurjchem-2534	440	54	.	.	PUNCT
eurjchem-2534	441	1	molecules	molecule	NOUN
eurjchem-2534	441	2	2017	2017	NUM
eurjchem-2534	441	3	,	,	PUNCT
eurjchem-2534	441	4	22	22	NUM
eurjchem-2534	441	5	,	,	PUNCT
eurjchem-2534	441	6	742	742	NUM
eurjchem-2534	441	7	.	.	PUNCT
eurjchem-2534	442	1	[	[	X
eurjchem-2534	442	2	35	35	NUM
eurjchem-2534	442	3	]	]	SYM
eurjchem-2534	442	4	.	.	PUNCT
eurjchem-2534	442	5	tang	tang	PROPN
eurjchem-2534	442	6	,	,	PUNCT
eurjchem-2534	442	7	k.	k.	PROPN
eurjchem-2534	442	8	;	;	PUNCT
eurjchem-2534	442	9	huang	huang	PROPN
eurjchem-2534	442	10	,	,	PUNCT
eurjchem-2534	442	11	j.	j.	PROPN
eurjchem-2534	442	12	;	;	PUNCT
eurjchem-2534	442	13	pan	pan	PROPN
eurjchem-2534	442	14	,	,	PUNCT
eurjchem-2534	442	15	j.	j.	PROPN
eurjchem-2534	442	16	;	;	PUNCT
eurjchem-2534	442	17	zhang	zhang	PROPN
eurjchem-2534	442	18	,	,	PUNCT
eurjchem-2534	442	19	x.	x.	PROPN
eurjchem-2534	442	20	;	;	PUNCT
eurjchem-2534	442	21	lu	lu	PROPN
eurjchem-2534	442	22	,	,	PUNCT
eurjchem-2534	442	23	w.	w.	PROPN
eurjchem-2534	442	24	design	design	PROPN
eurjchem-2534	442	25	,	,	PUNCT
eurjchem-2534	442	26	synthesis	synthesis	NOUN
eurjchem-2534	442	27	and	and	CCONJ
eurjchem-2534	442	28	biological	biological	ADJ
eurjchem-2534	442	29	evaluation	evaluation	NOUN
eurjchem-2534	442	30	of	of	ADP
eurjchem-2534	442	31	c(6)-indole	c(6)-indole	NOUN
eurjchem-2534	442	32	celastrol	celastrol	NOUN
eurjchem-2534	442	33	derivatives	derivative	NOUN
eurjchem-2534	442	34	as	as	ADP
eurjchem-2534	442	35	potential	potential	ADJ
eurjchem-2534	442	36	antitumor	antitumor	PROPN
eurjchem-2534	442	37	agents	agent	NOUN
eurjchem-2534	442	38	.	.	PUNCT
eurjchem-2534	443	1	rsc	rsc	PROPN
eurjchem-2534	443	2	adv	adv	PROPN
eurjchem-2534	443	3	.	.	PROPN
eurjchem-2534	443	4	2015	2015	NUM
eurjchem-2534	443	5	,	,	PUNCT
eurjchem-2534	443	6	5	5	NUM
eurjchem-2534	443	7	,	,	PUNCT
eurjchem-2534	443	8	19620–19623	19620–19623	NUM
eurjchem-2534	443	9	.	.	PUNCT
eurjchem-2534	444	1	[	[	X
eurjchem-2534	444	2	36	36	NUM
eurjchem-2534	444	3	]	]	PUNCT
eurjchem-2534	444	4	.	.	PUNCT
eurjchem-2534	445	1	he	he	PRON
eurjchem-2534	445	2	,	,	PUNCT
eurjchem-2534	445	3	q.-w	q.-w	PROPN
eurjchem-2534	445	4	.	.	PUNCT
eurjchem-2534	445	5	;	;	PUNCT
eurjchem-2534	445	6	feng	feng	PROPN
eurjchem-2534	445	7	,	,	PUNCT
eurjchem-2534	445	8	j.-h	j.-h	PROPN
eurjchem-2534	445	9	.	.	PUNCT
eurjchem-2534	445	10	;	;	PUNCT
eurjchem-2534	445	11	hu	hu	PROPN
eurjchem-2534	445	12	,	,	PUNCT
eurjchem-2534	445	13	x.-l	x.-l	PROPN
eurjchem-2534	445	14	.	.	PUNCT
eurjchem-2534	445	15	;	;	PUNCT
eurjchem-2534	445	16	long	long	ADV
eurjchem-2534	445	17	,	,	PUNCT
eurjchem-2534	445	18	h.	h.	PROPN
eurjchem-2534	445	19	;	;	PUNCT
eurjchem-2534	445	20	huang	huang	PROPN
eurjchem-2534	445	21	,	,	PUNCT
eurjchem-2534	445	22	x.-f	x.-f	NOUN
eurjchem-2534	445	23	.	.	PUNCT
eurjchem-2534	445	24	;	;	PUNCT
eurjchem-2534	445	25	jiang	jiang	PROPN
eurjchem-2534	445	26	,	,	PUNCT
eurjchem-2534	445	27	z.-z	z.-z	PROPN
eurjchem-2534	445	28	.	.	PUNCT
eurjchem-2534	445	29	;	;	PUNCT
eurjchem-2534	445	30	zhang	zhang	PROPN
eurjchem-2534	445	31	,	,	PUNCT
eurjchem-2534	445	32	x.-q	x.-q	PROPN
eurjchem-2534	445	33	.	.	PROPN
eurjchem-2534	445	34	;	;	PUNCT
eurjchem-2534	445	35	ye	ye	NOUN
eurjchem-2534	445	36	,	,	PUNCT
eurjchem-2534	445	37	w.-c	w.-c	NOUN
eurjchem-2534	445	38	.	.	PUNCT
eurjchem-2534	445	39	;	;	PUNCT
eurjchem-2534	445	40	wang	wang	PROPN
eurjchem-2534	445	41	,	,	PUNCT
eurjchem-2534	445	42	h.	h.	NOUN
eurjchem-2534	445	43	synthesis	synthesis	NOUN
eurjchem-2534	445	44	and	and	CCONJ
eurjchem-2534	445	45	biological	biological	ADJ
eurjchem-2534	445	46	evaluation	evaluation	NOUN
eurjchem-2534	445	47	of	of	ADP
eurjchem-2534	445	48	celastrol	celastrol	NOUN
eurjchem-2534	445	49	derivatives	derivative	NOUN
eurjchem-2534	445	50	as	as	ADP
eurjchem-2534	445	51	potential	potential	ADJ
eurjchem-2534	445	52	immunosuppressive	immunosuppressive	ADJ
eurjchem-2534	445	53	agents	agent	NOUN
eurjchem-2534	445	54	.	.	PUNCT
eurjchem-2534	446	1	j.	j.	PROPN
eurjchem-2534	446	2	nat	nat	PROPN
eurjchem-2534	446	3	.	.	PUNCT
eurjchem-2534	447	1	prod	prod	PROPN
eurjchem-2534	447	2	.	.	PUNCT
eurjchem-2534	448	1	2020	2020	NUM
eurjchem-2534	448	2	,	,	PUNCT
eurjchem-2534	448	3	83	83	NUM
eurjchem-2534	448	4	,	,	PUNCT
eurjchem-2534	448	5	2578–2586	2578–2586	NUM
eurjchem-2534	448	6	.	.	PUNCT
eurjchem-2534	449	1	[	[	X
eurjchem-2534	449	2	37	37	NUM
eurjchem-2534	449	3	]	]	PUNCT
eurjchem-2534	449	4	.	.	PUNCT
eurjchem-2534	449	5	westerheide	westerheide	PROPN
eurjchem-2534	449	6	,	,	PUNCT
eurjchem-2534	449	7	s.	s.	PROPN
eurjchem-2534	449	8	d.	d.	PROPN
eurjchem-2534	449	9	;	;	PUNCT
eurjchem-2534	449	10	bosman	bosman	PROPN
eurjchem-2534	449	11	,	,	PUNCT
eurjchem-2534	449	12	j.	j.	PROPN
eurjchem-2534	449	13	d.	d.	PROPN
eurjchem-2534	449	14	;	;	PUNCT
eurjchem-2534	449	15	mbadugha	mbadugha	PROPN
eurjchem-2534	449	16	,	,	PUNCT
eurjchem-2534	449	17	b.	b.	PROPN
eurjchem-2534	449	18	n.	n.	PROPN
eurjchem-2534	449	19	a.	a.	PROPN
eurjchem-2534	449	20	;	;	PUNCT
eurjchem-2534	449	21	kawahara	kawahara	PROPN
eurjchem-2534	449	22	,	,	PUNCT
eurjchem-2534	449	23	t.	t.	PROPN
eurjchem-2534	449	24	l.	l.	PROPN
eurjchem-2534	449	25	a.	a.	PROPN
eurjchem-2534	449	26	;	;	PUNCT
eurjchem-2534	449	27	matsumoto	matsumoto	PROPN
eurjchem-2534	449	28	,	,	PUNCT
eurjchem-2534	449	29	g.	g.	PROPN
eurjchem-2534	449	30	;	;	PUNCT
eurjchem-2534	449	31	kim	kim	PROPN
eurjchem-2534	449	32	,	,	PUNCT
eurjchem-2534	449	33	s.	s.	PROPN
eurjchem-2534	449	34	;	;	PUNCT
eurjchem-2534	449	35	gu	gu	PROPN
eurjchem-2534	449	36	,	,	PUNCT
eurjchem-2534	449	37	w.	w.	PROPN
eurjchem-2534	449	38	;	;	PUNCT
eurjchem-2534	449	39	devlin	devlin	PROPN
eurjchem-2534	449	40	,	,	PUNCT
eurjchem-2534	449	41	j.	j.	PROPN
eurjchem-2534	449	42	p.	p.	PROPN
eurjchem-2534	449	43	;	;	PUNCT
eurjchem-2534	449	44	silverman	silverman	PROPN
eurjchem-2534	449	45	,	,	PUNCT
eurjchem-2534	449	46	r.	r.	PROPN
eurjchem-2534	449	47	b.	b.	PROPN
eurjchem-2534	449	48	;	;	PUNCT
eurjchem-2534	449	49	morimoto	morimoto	PROPN
eurjchem-2534	449	50	,	,	PUNCT
eurjchem-2534	449	51	r.	r.	PROPN
eurjchem-2534	449	52	i.	i.	PROPN
eurjchem-2534	449	53	celastrols	celastrols	PROPN
eurjchem-2534	449	54	as	as	ADP
eurjchem-2534	449	55	inducers	inducer	NOUN
eurjchem-2534	449	56	of	of	ADP
eurjchem-2534	449	57	the	the	DET
eurjchem-2534	449	58	heat	heat	NOUN
eurjchem-2534	449	59	shock	shock	NOUN
eurjchem-2534	449	60	response	response	NOUN
eurjchem-2534	449	61	and	and	CCONJ
eurjchem-2534	449	62	cytoprotection	cytoprotection	NOUN
eurjchem-2534	449	63	.	.	PUNCT
eurjchem-2534	450	1	j.	j.	PROPN
eurjchem-2534	450	2	biol	biol	PROPN
eurjchem-2534	450	3	.	.	PUNCT
eurjchem-2534	451	1	chem	chem	PROPN
eurjchem-2534	451	2	.	.	PUNCT
eurjchem-2534	452	1	2004	2004	NUM
eurjchem-2534	452	2	,	,	PUNCT
eurjchem-2534	452	3	279	279	NUM
eurjchem-2534	452	4	,	,	PUNCT
eurjchem-2534	452	5	56053–56060	56053–56060	NOUN
eurjchem-2534	452	6	.	.	PUNCT
eurjchem-2534	453	1	[	[	X
eurjchem-2534	453	2	38	38	NUM
eurjchem-2534	453	3	]	]	PUNCT
eurjchem-2534	453	4	.	.	PUNCT
eurjchem-2534	454	1	pokorny	pokorny	PROPN
eurjchem-2534	454	2	,	,	PUNCT
eurjchem-2534	454	3	j.	j.	PROPN
eurjchem-2534	454	4	;	;	PUNCT
eurjchem-2534	454	5	borkova	borkova	VERB
eurjchem-2534	454	6	,	,	PUNCT
eurjchem-2534	454	7	l.	l.	PROPN
eurjchem-2534	454	8	;	;	PUNCT
eurjchem-2534	454	9	urban	urban	ADJ
eurjchem-2534	454	10	,	,	PUNCT
eurjchem-2534	454	11	m.	m.	NOUN
eurjchem-2534	454	12	click	click	VERB
eurjchem-2534	454	13	reactions	reaction	NOUN
eurjchem-2534	454	14	in	in	ADP
eurjchem-2534	454	15	chemistry	chemistry	NOUN
eurjchem-2534	454	16	of	of	ADP
eurjchem-2534	454	17	triterpenes	triterpene	NOUN
eurjchem-2534	454	18	advances	advance	NOUN
eurjchem-2534	454	19	towards	towards	ADP
eurjchem-2534	454	20	development	development	NOUN
eurjchem-2534	454	21	of	of	ADP
eurjchem-2534	454	22	potential	potential	ADJ
eurjchem-2534	454	23	therapeutics	therapeutic	NOUN
eurjchem-2534	454	24	.	.	PUNCT
eurjchem-2534	455	1	curr	curr	AUX
eurjchem-2534	455	2	.	.	PUNCT
eurjchem-2534	455	3	med	med	PROPN
eurjchem-2534	455	4	.	.	PROPN
eurjchem-2534	455	5	chem	chem	PROPN
eurjchem-2534	455	6	.	.	PUNCT
eurjchem-2534	456	1	2018	2018	NUM
eurjchem-2534	456	2	,	,	PUNCT
eurjchem-2534	456	3	25	25	NUM
eurjchem-2534	456	4	,	,	PUNCT
eurjchem-2534	456	5	636–658	636–658	NUM
eurjchem-2534	456	6	.	.	PUNCT
eurjchem-2534	457	1	[	[	X
eurjchem-2534	457	2	39	39	NUM
eurjchem-2534	457	3	]	]	PUNCT
eurjchem-2534	457	4	.	.	PUNCT
eurjchem-2534	457	5	tornøe	tornøe	PROPN
eurjchem-2534	457	6	,	,	PUNCT
eurjchem-2534	457	7	c.	c.	PROPN
eurjchem-2534	457	8	w.	w.	PROPN
eurjchem-2534	457	9	;	;	PUNCT
eurjchem-2534	457	10	christensen	christensen	PROPN
eurjchem-2534	457	11	,	,	PUNCT
eurjchem-2534	457	12	c.	c.	PROPN
eurjchem-2534	457	13	;	;	PUNCT
eurjchem-2534	457	14	meldal	meldal	NOUN
eurjchem-2534	457	15	,	,	PUNCT
eurjchem-2534	457	16	m.	m.	NOUN
eurjchem-2534	457	17	peptidotriazoles	peptidotriazole	NOUN
eurjchem-2534	457	18	on	on	ADP
eurjchem-2534	457	19	solid	solid	ADJ
eurjchem-2534	457	20	phase	phase	NOUN
eurjchem-2534	457	21	:	:	PUNCT
eurjchem-2534	457	22	[	[	X
eurjchem-2534	457	23	1,2,3]-triazoles	1,2,3]-triazoles	NUM
eurjchem-2534	457	24	by	by	ADP
eurjchem-2534	457	25	regiospecific	regiospecific	NOUN
eurjchem-2534	457	26	copper(i)-catalyzed	copper(i)-catalyze	VERB
eurjchem-2534	457	27	1,3dipolar	1,3dipolar	NUM
eurjchem-2534	457	28	cycloadditions	cycloaddition	NOUN
eurjchem-2534	457	29	of	of	ADP
eurjchem-2534	457	30	terminal	terminal	ADJ
eurjchem-2534	457	31	alkynes	alkyne	NOUN
eurjchem-2534	457	32	to	to	ADP
eurjchem-2534	457	33	azides	azides	PROPN
eurjchem-2534	457	34	.	.	PUNCT
eurjchem-2534	458	1	j.	j.	PROPN
eurjchem-2534	458	2	org	org	PROPN
eurjchem-2534	458	3	.	.	PUNCT
eurjchem-2534	458	4	chem	chem	PROPN
eurjchem-2534	458	5	.	.	PUNCT
eurjchem-2534	459	1	2002	2002	NUM
eurjchem-2534	459	2	,	,	PUNCT
eurjchem-2534	459	3	67	67	NUM
eurjchem-2534	459	4	,	,	PUNCT
eurjchem-2534	459	5	3057–3064	3057–3064	NUM
eurjchem-2534	459	6	.	.	PUNCT
eurjchem-2534	460	1	https://www.fdct.gov.mo/en	https://www.fdct.gov.mo/en	NOUN
eurjchem-2534	460	2	mailto:2230028575@student.must.edu.mo	mailto:2230028575@student.must.edu.mo	PROPN
eurjchem-2534	460	3	https://orcid.org/0009-0007-2534-444x	https://orcid.org/0009-0007-2534-444x	PROPN
eurjchem-2534	460	4	mailto:coghips@must.edu.mo	mailto:coghips@must.edu.mo	NOUN
eurjchem-2534	460	5	https://orcid.org/0000-0002-0015-1453	https://orcid.org/0000-0002-0015-1453	NOUN
eurjchem-2534	460	6	http://www.tcmip.cn/etcm2/front/#/	http://www.tcmip.cn/etcm2/front/#/	PROPN
eurjchem-2534	460	7	204	204	NUM
eurjchem-2534	460	8	ren	ren	NOUN
eurjchem-2534	460	9	and	and	CCONJ
eurjchem-2534	460	10	coghi	coghi	PROPN
eurjchem-2534	460	11	/	/	SYM
eurjchem-2534	460	12	european	european	PROPN
eurjchem-2534	460	13	journal	journal	PROPN
eurjchem-2534	460	14	of	of	ADP
eurjchem-2534	460	15	chemistry	chemistry	NOUN
eurjchem-2534	460	16	15	15	NUM
eurjchem-2534	460	17	(	(	PUNCT
eurjchem-2534	460	18	2	2	NUM
eurjchem-2534	460	19	)	)	PUNCT
eurjchem-2534	460	20	(	(	PUNCT
eurjchem-2534	460	21	2024	2024	NUM
eurjchem-2534	460	22	)	)	PUNCT
eurjchem-2534	460	23	194	194	NUM
eurjchem-2534	460	24	-	-	SYM
eurjchem-2534	460	25	204	204	NUM
eurjchem-2534	460	26	2024	2024	NUM
eurjchem-2534	460	27	–	–	PUNCT
eurjchem-2534	460	28	european	european	ADJ
eurjchem-2534	460	29	journal	journal	NOUN
eurjchem-2534	460	30	of	of	ADP
eurjchem-2534	460	31	chemistry	chemistry	NOUN
eurjchem-2534	460	32	–	–	PUNCT
eurjchem-2534	460	33	cc	cc	NOUN
eurjchem-2534	460	34	by	by	ADP
eurjchem-2534	460	35	nc	nc	PROPN
eurjchem-2534	460	36	–	–	PUNCT
eurjchem-2534	460	37	doi	doi	PROPN
eurjchem-2534	460	38	:	:	PUNCT
eurjchem-2534	460	39	10.5155	10.5155	NUM
eurjchem-2534	460	40	/	/	SYM
eurjchem-2534	460	41	eurjchem.15.2.194	eurjchem.15.2.194	NOUN
eurjchem-2534	460	42	-	-	SYM
eurjchem-2534	460	43	204.2534	204.2534	NUM
eurjchem-2534	460	44	[	[	X
eurjchem-2534	460	45	40	40	NUM
eurjchem-2534	460	46	]	]	PUNCT
eurjchem-2534	460	47	.	.	PUNCT
eurjchem-2534	461	1	rostovtsev	rostovtsev	PROPN
eurjchem-2534	461	2	,	,	PUNCT
eurjchem-2534	461	3	v.	v.	PROPN
eurjchem-2534	462	1	v.	v.	ADP
eurjchem-2534	462	2	;	;	PUNCT
eurjchem-2534	462	3	green	green	ADJ
eurjchem-2534	462	4	,	,	PUNCT
eurjchem-2534	462	5	l.	l.	PROPN
eurjchem-2534	462	6	g.	g.	PROPN
eurjchem-2534	462	7	;	;	PUNCT
eurjchem-2534	463	1	fokin	fokin	PROPN
eurjchem-2534	463	2	,	,	PUNCT
eurjchem-2534	463	3	v.	v.	PROPN
eurjchem-2534	463	4	v.	v.	ADP
eurjchem-2534	463	5	;	;	PUNCT
eurjchem-2534	463	6	sharpless	sharpless	NOUN
eurjchem-2534	463	7	,	,	PUNCT
eurjchem-2534	463	8	k.	k.	PROPN
eurjchem-2534	463	9	b.	b.	PROPN
eurjchem-2534	464	1	a	a	DET
eurjchem-2534	464	2	stepwise	stepwise	PROPN
eurjchem-2534	464	3	huisgen	huisgen	PROPN
eurjchem-2534	464	4	cycloaddition	cycloaddition	NOUN
eurjchem-2534	464	5	process	process	NOUN
eurjchem-2534	464	6	:	:	PUNCT
eurjchem-2534	464	7	copper(i)-catalyzed	copper(i)-catalyzed	ADJ
eurjchem-2534	464	8	regioselective	regioselective	ADJ
eurjchem-2534	464	9	“	"	PUNCT
eurjchem-2534	464	10	ligation	ligation	NOUN
eurjchem-2534	464	11	”	"	PUNCT
eurjchem-2534	464	12	of	of	ADP
eurjchem-2534	464	13	azides	azide	NOUN
eurjchem-2534	464	14	and	and	CCONJ
eurjchem-2534	464	15	terminal	terminal	ADJ
eurjchem-2534	464	16	alkynes	alkyne	NOUN
eurjchem-2534	464	17	.	.	PUNCT
eurjchem-2534	465	1	angew	angew	PROPN
eurjchem-2534	465	2	.	.	PUNCT
eurjchem-2534	466	1	chem	chem	PROPN
eurjchem-2534	466	2	.	.	PUNCT
eurjchem-2534	467	1	int	int	NOUN
eurjchem-2534	467	2	.	.	PUNCT
eurjchem-2534	468	1	ed	ed	PROPN
eurjchem-2534	468	2	engl	engl	PROPN
eurjchem-2534	468	3	.	.	PROPN
eurjchem-2534	469	1	2002	2002	NUM
eurjchem-2534	469	2	,	,	PUNCT
eurjchem-2534	469	3	41	41	NUM
eurjchem-2534	469	4	,	,	PUNCT
eurjchem-2534	469	5	2596–2599	2596–2599	NUM
eurjchem-2534	469	6	.	.	PUNCT
eurjchem-2534	470	1	[	[	X
eurjchem-2534	470	2	41	41	NUM
eurjchem-2534	470	3	]	]	PUNCT
eurjchem-2534	470	4	.	.	PUNCT
eurjchem-2534	471	1	bozorov	bozorov	PROPN
eurjchem-2534	471	2	,	,	PUNCT
eurjchem-2534	471	3	k.	k.	PROPN
eurjchem-2534	471	4	;	;	PUNCT
eurjchem-2534	471	5	zhao	zhao	PROPN
eurjchem-2534	471	6	,	,	PUNCT
eurjchem-2534	471	7	j.	j.	PROPN
eurjchem-2534	471	8	;	;	PUNCT
eurjchem-2534	471	9	aisa	aisa	PROPN
eurjchem-2534	471	10	,	,	PUNCT
eurjchem-2534	472	1	h.	h.	PROPN
eurjchem-2534	472	2	a.	a.	NOUN
eurjchem-2534	472	3	1,2,3	1,2,3	NUM
eurjchem-2534	472	4	-	-	PUNCT
eurjchem-2534	472	5	triazole	triazole	NOUN
eurjchem-2534	472	6	-	-	PUNCT
eurjchem-2534	472	7	containing	contain	VERB
eurjchem-2534	472	8	hybrids	hybrid	NOUN
eurjchem-2534	472	9	as	as	ADP
eurjchem-2534	472	10	leads	lead	NOUN
eurjchem-2534	472	11	in	in	ADP
eurjchem-2534	472	12	medicinal	medicinal	ADJ
eurjchem-2534	472	13	chemistry	chemistry	NOUN
eurjchem-2534	472	14	:	:	PUNCT
eurjchem-2534	472	15	a	a	DET
eurjchem-2534	472	16	recent	recent	ADJ
eurjchem-2534	472	17	overview	overview	NOUN
eurjchem-2534	472	18	.	.	PUNCT
eurjchem-2534	473	1	bioorg	bioorg	VERB
eurjchem-2534	473	2	.	.	PUNCT
eurjchem-2534	474	1	med	med	PROPN
eurjchem-2534	474	2	.	.	PUNCT
eurjchem-2534	474	3	chem	chem	PROPN
eurjchem-2534	474	4	.	.	PUNCT
eurjchem-2534	475	1	2019	2019	NUM
eurjchem-2534	475	2	,	,	PUNCT
eurjchem-2534	475	3	27	27	NUM
eurjchem-2534	475	4	,	,	PUNCT
eurjchem-2534	475	5	3511–3531	3511–3531	NUM
eurjchem-2534	475	6	.	.	PUNCT
eurjchem-2534	476	1	[	[	X
eurjchem-2534	476	2	42	42	NUM
eurjchem-2534	476	3	]	]	PUNCT
eurjchem-2534	476	4	.	.	PUNCT
eurjchem-2534	477	1	wu	wu	PROPN
eurjchem-2534	477	2	,	,	PUNCT
eurjchem-2534	478	1	p.	p.	PROPN
eurjchem-2534	478	2	the	the	DET
eurjchem-2534	478	3	nobel	nobel	PROPN
eurjchem-2534	478	4	prize	prize	PROPN
eurjchem-2534	478	5	in	in	ADP
eurjchem-2534	478	6	chemistry	chemistry	NOUN
eurjchem-2534	478	7	2022	2022	NUM
eurjchem-2534	478	8	:	:	PUNCT
eurjchem-2534	478	9	fulfilling	fulfil	VERB
eurjchem-2534	478	10	demanding	demand	VERB
eurjchem-2534	478	11	applications	application	NOUN
eurjchem-2534	478	12	with	with	ADP
eurjchem-2534	478	13	simple	simple	ADJ
eurjchem-2534	478	14	reactions	reaction	NOUN
eurjchem-2534	478	15	.	.	PUNCT
eurjchem-2534	479	1	acs	acs	PROPN
eurjchem-2534	479	2	chem	chem	PROPN
eurjchem-2534	479	3	.	.	PUNCT
eurjchem-2534	480	1	biol	biol	PROPN
eurjchem-2534	480	2	.	.	PUNCT
eurjchem-2534	481	1	2022	2022	NUM
eurjchem-2534	481	2	,	,	PUNCT
eurjchem-2534	481	3	17	17	NUM
eurjchem-2534	481	4	,	,	PUNCT
eurjchem-2534	481	5	2959	2959	NUM
eurjchem-2534	481	6	–	–	PUNCT
eurjchem-2534	481	7	2961	2961	NUM
eurjchem-2534	481	8	.	.	PUNCT
eurjchem-2534	482	1	[	[	X
eurjchem-2534	482	2	43	43	NUM
eurjchem-2534	482	3	]	]	PUNCT
eurjchem-2534	482	4	.	.	PUNCT
eurjchem-2534	483	1	zhang	zhang	PROPN
eurjchem-2534	483	2	,	,	PUNCT
eurjchem-2534	483	3	h.-j	h.-j	PROPN
eurjchem-2534	483	4	.	.	PUNCT
eurjchem-2534	483	5	;	;	PUNCT
eurjchem-2534	483	6	zhang	zhang	PROPN
eurjchem-2534	483	7	,	,	PUNCT
eurjchem-2534	483	8	g.-r	g.-r	PROPN
eurjchem-2534	483	9	.	.	PROPN
eurjchem-2534	483	10	;	;	PUNCT
eurjchem-2534	483	11	piao	piao	NOUN
eurjchem-2534	483	12	,	,	PUNCT
eurjchem-2534	483	13	h.-r	h.-r	NOUN
eurjchem-2534	483	14	.	.	PUNCT
eurjchem-2534	483	15	;	;	PUNCT
eurjchem-2534	483	16	quan	quan	PROPN
eurjchem-2534	483	17	,	,	PUNCT
eurjchem-2534	483	18	z.-s	z.-	NOUN
eurjchem-2534	483	19	.	.	PUNCT
eurjchem-2534	484	1	synthesis	synthesis	NOUN
eurjchem-2534	484	2	and	and	CCONJ
eurjchem-2534	484	3	characterisation	characterisation	NOUN
eurjchem-2534	484	4	of	of	ADP
eurjchem-2534	484	5	celastrol	celastrol	NOUN
eurjchem-2534	484	6	derivatives	derivative	NOUN
eurjchem-2534	484	7	as	as	ADP
eurjchem-2534	484	8	potential	potential	ADJ
eurjchem-2534	484	9	anticancer	anticancer	NOUN
eurjchem-2534	484	10	agents	agent	NOUN
eurjchem-2534	484	11	.	.	PUNCT
eurjchem-2534	485	1	j.	j.	PROPN
eurjchem-2534	485	2	enzyme	enzyme	NOUN
eurjchem-2534	485	3	inhib	inhib	NOUN
eurjchem-2534	485	4	.	.	PUNCT
eurjchem-2534	486	1	med	med	PROPN
eurjchem-2534	486	2	.	.	PUNCT
eurjchem-2534	486	3	chem	chem	PROPN
eurjchem-2534	486	4	.	.	PUNCT
eurjchem-2534	487	1	2018	2018	NUM
eurjchem-2534	487	2	,	,	PUNCT
eurjchem-2534	487	3	33	33	NUM
eurjchem-2534	487	4	,	,	PUNCT
eurjchem-2534	487	5	190–198	190–198	NUM
eurjchem-2534	487	6	.	.	PUNCT
eurjchem-2534	488	1	[	[	X
eurjchem-2534	488	2	44	44	NUM
eurjchem-2534	488	3	]	]	PUNCT
eurjchem-2534	488	4	.	.	PUNCT
eurjchem-2534	489	1	feng	feng	PROPN
eurjchem-2534	489	2	,	,	PUNCT
eurjchem-2534	489	3	y.	y.	PROPN
eurjchem-2534	489	4	;	;	PUNCT
eurjchem-2534	489	5	wang	wang	PROPN
eurjchem-2534	489	6	,	,	PUNCT
eurjchem-2534	489	7	w.	w.	PROPN
eurjchem-2534	489	8	;	;	PUNCT
eurjchem-2534	489	9	zhang	zhang	PROPN
eurjchem-2534	489	10	,	,	PUNCT
eurjchem-2534	489	11	y.	y.	PROPN
eurjchem-2534	489	12	;	;	PUNCT
eurjchem-2534	489	13	fu	fu	PROPN
eurjchem-2534	489	14	,	,	PUNCT
eurjchem-2534	489	15	x.	x.	NOUN
eurjchem-2534	489	16	;	;	PUNCT
eurjchem-2534	489	17	ping	ping	PROPN
eurjchem-2534	489	18	,	,	PUNCT
eurjchem-2534	489	19	k.	k.	PROPN
eurjchem-2534	489	20	;	;	PUNCT
eurjchem-2534	489	21	zhao	zhao	PROPN
eurjchem-2534	489	22	,	,	PUNCT
eurjchem-2534	489	23	j.	j.	PROPN
eurjchem-2534	489	24	;	;	PUNCT
eurjchem-2534	489	25	lei	lei	PROPN
eurjchem-2534	489	26	,	,	PUNCT
eurjchem-2534	489	27	y.	y.	PROPN
eurjchem-2534	489	28	;	;	PUNCT
eurjchem-2534	489	29	mou	mou	PROPN
eurjchem-2534	489	30	,	,	PUNCT
eurjchem-2534	489	31	y.	y.	PROPN
eurjchem-2534	489	32	;	;	PUNCT
eurjchem-2534	489	33	wang	wang	PROPN
eurjchem-2534	489	34	,	,	PUNCT
eurjchem-2534	489	35	s.	s.	PROPN
eurjchem-2534	489	36	synthesis	synthesis	NOUN
eurjchem-2534	489	37	and	and	CCONJ
eurjchem-2534	489	38	biological	biological	ADJ
eurjchem-2534	489	39	evaluation	evaluation	NOUN
eurjchem-2534	489	40	of	of	ADP
eurjchem-2534	489	41	celastrol	celastrol	NOUN
eurjchem-2534	489	42	derivatives	derivative	NOUN
eurjchem-2534	489	43	as	as	ADP
eurjchem-2534	489	44	potential	potential	ADJ
eurjchem-2534	489	45	anti	anti	ADJ
eurjchem-2534	489	46	-	-	ADJ
eurjchem-2534	489	47	glioma	glioma	ADJ
eurjchem-2534	489	48	agents	agent	NOUN
eurjchem-2534	489	49	by	by	ADP
eurjchem-2534	489	50	activating	activate	VERB
eurjchem-2534	489	51	rip1	rip1	PROPN
eurjchem-2534	489	52	/	/	SYM
eurjchem-2534	489	53	rip3	rip3	PROPN
eurjchem-2534	489	54	/	/	SYM
eurjchem-2534	489	55	mlkl	mlkl	VERB
eurjchem-2534	489	56	pathway	pathway	NOUN
eurjchem-2534	489	57	to	to	PART
eurjchem-2534	489	58	induce	induce	VERB
eurjchem-2534	489	59	necroptosis	necroptosis	NOUN
eurjchem-2534	489	60	.	.	PUNCT
eurjchem-2534	490	1	eur	eur	PROPN
eurjchem-2534	490	2	.	.	PUNCT
eurjchem-2534	491	1	j.	j.	PROPN
eurjchem-2534	491	2	med	med	PROPN
eurjchem-2534	491	3	.	.	PROPN
eurjchem-2534	491	4	chem	chem	PROPN
eurjchem-2534	491	5	.	.	PUNCT
eurjchem-2534	492	1	2022	2022	NUM
eurjchem-2534	492	2	,	,	PUNCT
eurjchem-2534	492	3	229	229	NUM
eurjchem-2534	492	4	,	,	PUNCT
eurjchem-2534	492	5	114070	114070	NUM
eurjchem-2534	492	6	.	.	PUNCT
eurjchem-2534	493	1	[	[	X
eurjchem-2534	493	2	45	45	NUM
eurjchem-2534	493	3	]	]	PUNCT
eurjchem-2534	493	4	.	.	PUNCT
eurjchem-2534	494	1	shang	shang	PROPN
eurjchem-2534	494	2	,	,	PUNCT
eurjchem-2534	494	3	f.-f	f.-f	PROPN
eurjchem-2534	494	4	.	.	PUNCT
eurjchem-2534	494	5	;	;	PUNCT
eurjchem-2534	494	6	wang	wang	PROPN
eurjchem-2534	494	7	,	,	PUNCT
eurjchem-2534	494	8	j.	j.	PROPN
eurjchem-2534	494	9	y.	y.	PROPN
eurjchem-2534	494	10	;	;	PUNCT
eurjchem-2534	494	11	xu	xu	PROPN
eurjchem-2534	494	12	,	,	PUNCT
eurjchem-2534	494	13	q.	q.	PROPN
eurjchem-2534	494	14	;	;	PUNCT
eurjchem-2534	494	15	deng	deng	PROPN
eurjchem-2534	494	16	,	,	PUNCT
eurjchem-2534	494	17	h.	h.	PROPN
eurjchem-2534	494	18	;	;	PUNCT
eurjchem-2534	494	19	guo	guo	PROPN
eurjchem-2534	494	20	,	,	PUNCT
eurjchem-2534	494	21	h.-y	h.-y	NOUN
eurjchem-2534	494	22	.	.	PUNCT
eurjchem-2534	494	23	;	;	PUNCT
eurjchem-2534	494	24	jin	jin	NOUN
eurjchem-2534	494	25	,	,	PUNCT
eurjchem-2534	494	26	x.	x.	PROPN
eurjchem-2534	494	27	;	;	PUNCT
eurjchem-2534	494	28	li	li	PROPN
eurjchem-2534	494	29	,	,	PUNCT
eurjchem-2534	494	30	x.	x.	PROPN
eurjchem-2534	494	31	;	;	PUNCT
eurjchem-2534	494	32	shen	shen	PROPN
eurjchem-2534	494	33	,	,	PUNCT
eurjchem-2534	494	34	q.-k	q.-k	PROPN
eurjchem-2534	494	35	.	.	PUNCT
eurjchem-2534	494	36	;	;	PUNCT
eurjchem-2534	494	37	quan	quan	PROPN
eurjchem-2534	494	38	,	,	PUNCT
eurjchem-2534	494	39	z.-s	z.-s	PROPN
eurjchem-2534	494	40	.	.	PUNCT
eurjchem-2534	495	1	design	design	NOUN
eurjchem-2534	495	2	,	,	PUNCT
eurjchem-2534	495	3	synthesis	synthesis	NOUN
eurjchem-2534	495	4	of	of	ADP
eurjchem-2534	495	5	novel	novel	ADJ
eurjchem-2534	495	6	celastrol	celastrol	NOUN
eurjchem-2534	495	7	derivatives	derivative	NOUN
eurjchem-2534	495	8	and	and	CCONJ
eurjchem-2534	495	9	study	study	NOUN
eurjchem-2534	495	10	on	on	ADP
eurjchem-2534	495	11	their	their	PRON
eurjchem-2534	495	12	antitumor	antitumor	PROPN
eurjchem-2534	495	13	growth	growth	NOUN
eurjchem-2534	495	14	through	through	ADP
eurjchem-2534	495	15	hif-1α	hif-1α	NOUN
eurjchem-2534	495	16	pathway	pathway	NOUN
eurjchem-2534	495	17	.	.	PUNCT
eurjchem-2534	496	1	eur	eur	PROPN
eurjchem-2534	496	2	.	.	PUNCT
eurjchem-2534	497	1	j.	j.	PROPN
eurjchem-2534	497	2	med	med	PROPN
eurjchem-2534	497	3	.	.	PROPN
eurjchem-2534	497	4	chem	chem	PROPN
eurjchem-2534	497	5	.	.	PUNCT
eurjchem-2534	498	1	2021	2021	NUM
eurjchem-2534	498	2	,	,	PUNCT
eurjchem-2534	498	3	220	220	NUM
eurjchem-2534	498	4	,	,	PUNCT
eurjchem-2534	498	5	113474	113474	NUM
eurjchem-2534	498	6	.	.	PUNCT
eurjchem-2534	499	1	[	[	X
eurjchem-2534	499	2	46	46	NUM
eurjchem-2534	499	3	]	]	SYM
eurjchem-2534	499	4	.	.	PUNCT
eurjchem-2534	499	5	fang	fang	PROPN
eurjchem-2534	499	6	,	,	PUNCT
eurjchem-2534	499	7	g.	g.	PROPN
eurjchem-2534	499	8	;	;	PUNCT
eurjchem-2534	499	9	tang	tang	PROPN
eurjchem-2534	499	10	,	,	PUNCT
eurjchem-2534	499	11	b.	b.	PROPN
eurjchem-2534	499	12	current	current	PROPN
eurjchem-2534	499	13	advances	advance	NOUN
eurjchem-2534	499	14	in	in	ADP
eurjchem-2534	499	15	the	the	DET
eurjchem-2534	499	16	nano	nano	NOUN
eurjchem-2534	499	17	-	-	PUNCT
eurjchem-2534	499	18	delivery	delivery	NOUN
eurjchem-2534	499	19	of	of	ADP
eurjchem-2534	499	20	celastrol	celastrol	NOUN
eurjchem-2534	499	21	for	for	ADP
eurjchem-2534	499	22	treating	treat	VERB
eurjchem-2534	499	23	inflammation	inflammation	NOUN
eurjchem-2534	499	24	-	-	PUNCT
eurjchem-2534	499	25	associated	associate	VERB
eurjchem-2534	499	26	diseases	disease	NOUN
eurjchem-2534	499	27	.	.	PUNCT
eurjchem-2534	500	1	j.	j.	PROPN
eurjchem-2534	500	2	mater	mater	PROPN
eurjchem-2534	500	3	.	.	PUNCT
eurjchem-2534	501	1	chem	chem	PROPN
eurjchem-2534	501	2	.	.	PUNCT
eurjchem-2534	502	1	b	b	NOUN
eurjchem-2534	502	2	mater	mater	NOUN
eurjchem-2534	502	3	.	.	PUNCT
eurjchem-2534	503	1	biol	biol	PROPN
eurjchem-2534	503	2	.	.	PUNCT
eurjchem-2534	504	1	med	med	PROPN
eurjchem-2534	504	2	.	.	PUNCT
eurjchem-2534	505	1	2020	2020	NUM
eurjchem-2534	505	2	,	,	PUNCT
eurjchem-2534	505	3	8	8	NUM
eurjchem-2534	505	4	,	,	PUNCT
eurjchem-2534	505	5	10954–10965	10954–10965	NUM
eurjchem-2534	505	6	.	.	PUNCT
eurjchem-2534	506	1	[	[	X
eurjchem-2534	506	2	47	47	NUM
eurjchem-2534	506	3	]	]	PUNCT
eurjchem-2534	506	4	.	.	PUNCT
eurjchem-2534	507	1	sun	sun	PROPN
eurjchem-2534	507	2	,	,	PUNCT
eurjchem-2534	507	3	y.	y.	PROPN
eurjchem-2534	507	4	;	;	PUNCT
eurjchem-2534	507	5	wang	wang	PROPN
eurjchem-2534	507	6	,	,	PUNCT
eurjchem-2534	507	7	c.	c.	PROPN
eurjchem-2534	507	8	;	;	PUNCT
eurjchem-2534	507	9	li	li	PROPN
eurjchem-2534	507	10	,	,	PUNCT
eurjchem-2534	507	11	x.	x.	PROPN
eurjchem-2534	507	12	;	;	PUNCT
eurjchem-2534	507	13	lu	lu	PROPN
eurjchem-2534	507	14	,	,	PUNCT
eurjchem-2534	507	15	j.	j.	PROPN
eurjchem-2534	507	16	;	;	PUNCT
eurjchem-2534	507	17	wang	wang	PROPN
eurjchem-2534	507	18	,	,	PUNCT
eurjchem-2534	507	19	m.	m.	NOUN
eurjchem-2534	507	20	recent	recent	ADJ
eurjchem-2534	507	21	advances	advance	NOUN
eurjchem-2534	507	22	in	in	ADP
eurjchem-2534	507	23	drug	drug	NOUN
eurjchem-2534	507	24	delivery	delivery	NOUN
eurjchem-2534	507	25	of	of	ADP
eurjchem-2534	507	26	celastrol	celastrol	NOUN
eurjchem-2534	507	27	for	for	ADP
eurjchem-2534	507	28	enhancing	enhance	VERB
eurjchem-2534	507	29	efficiency	efficiency	NOUN
eurjchem-2534	507	30	and	and	CCONJ
eurjchem-2534	507	31	reducing	reduce	VERB
eurjchem-2534	507	32	the	the	DET
eurjchem-2534	507	33	toxicity	toxicity	NOUN
eurjchem-2534	507	34	.	.	PUNCT
eurjchem-2534	508	1	front	front	NOUN
eurjchem-2534	508	2	.	.	PUNCT
eurjchem-2534	509	1	pharmacol	pharmacol	PROPN
eurjchem-2534	509	2	.	.	PUNCT
eurjchem-2534	510	1	2024	2024	NUM
eurjchem-2534	510	2	,	,	PUNCT
eurjchem-2534	510	3	15	15	NUM
eurjchem-2534	510	4	,	,	PUNCT
eurjchem-2534	510	5	1137289	1137289	NUM
eurjchem-2534	510	6	.	.	PUNCT
eurjchem-2534	511	1	[	[	X
eurjchem-2534	511	2	48	48	NUM
eurjchem-2534	511	3	]	]	PUNCT
eurjchem-2534	511	4	.	.	PUNCT
eurjchem-2534	512	1	ge	ge	PROPN
eurjchem-2534	512	2	,	,	PUNCT
eurjchem-2534	512	3	p.	p.	PROPN
eurjchem-2534	512	4	;	;	PUNCT
eurjchem-2534	512	5	niu	niu	PROPN
eurjchem-2534	512	6	,	,	PUNCT
eurjchem-2534	512	7	b.	b.	PROPN
eurjchem-2534	512	8	;	;	PUNCT
eurjchem-2534	512	9	wu	wu	PROPN
eurjchem-2534	512	10	,	,	PUNCT
eurjchem-2534	512	11	y.	y.	PROPN
eurjchem-2534	512	12	;	;	PUNCT
eurjchem-2534	512	13	xu	xu	PROPN
eurjchem-2534	512	14	,	,	PUNCT
eurjchem-2534	512	15	w.	w.	PROPN
eurjchem-2534	512	16	;	;	PUNCT
eurjchem-2534	512	17	li	li	PROPN
eurjchem-2534	512	18	,	,	PUNCT
eurjchem-2534	512	19	m.	m.	NOUN
eurjchem-2534	512	20	;	;	PUNCT
eurjchem-2534	512	21	sun	sun	PROPN
eurjchem-2534	512	22	,	,	PUNCT
eurjchem-2534	512	23	h.	h.	PROPN
eurjchem-2534	512	24	;	;	PUNCT
eurjchem-2534	512	25	zhou	zhou	PROPN
eurjchem-2534	512	26	,	,	PUNCT
eurjchem-2534	512	27	h.	h.	PROPN
eurjchem-2534	512	28	;	;	PUNCT
eurjchem-2534	512	29	zhang	zhang	PROPN
eurjchem-2534	512	30	,	,	PUNCT
eurjchem-2534	512	31	x.	x.	PROPN
eurjchem-2534	512	32	;	;	PUNCT
eurjchem-2534	512	33	xie	xie	PROPN
eurjchem-2534	512	34	,	,	PUNCT
eurjchem-2534	512	35	j.	j.	PROPN
eurjchem-2534	512	36	enhanced	enhance	VERB
eurjchem-2534	512	37	cancer	cancer	NOUN
eurjchem-2534	512	38	therapy	therapy	NOUN
eurjchem-2534	512	39	of	of	ADP
eurjchem-2534	512	40	celastrol	celastrol	NOUN
eurjchem-2534	512	41	in	in	ADP
eurjchem-2534	512	42	vitro	vitro	X
eurjchem-2534	512	43	and	and	CCONJ
eurjchem-2534	512	44	in	in	ADP
eurjchem-2534	512	45	vivo	vivo	NOUN
eurjchem-2534	512	46	by	by	ADP
eurjchem-2534	512	47	smart	smart	ADJ
eurjchem-2534	512	48	dendrimers	dendrimer	NOUN
eurjchem-2534	512	49	delivery	delivery	NOUN
eurjchem-2534	512	50	with	with	ADP
eurjchem-2534	512	51	specificity	specificity	NOUN
eurjchem-2534	512	52	and	and	CCONJ
eurjchem-2534	512	53	biosafety	biosafety	NOUN
eurjchem-2534	512	54	.	.	PUNCT
eurjchem-2534	513	1	chem	chem	NOUN
eurjchem-2534	513	2	.	.	PUNCT
eurjchem-2534	514	1	eng	eng	PROPN
eurjchem-2534	514	2	.	.	PUNCT
eurjchem-2534	515	1	j.	j.	PROPN
eurjchem-2534	515	2	2020	2020	PROPN
eurjchem-2534	515	3	,	,	PUNCT
eurjchem-2534	515	4	383	383	NUM
eurjchem-2534	515	5	,	,	PUNCT
eurjchem-2534	515	6	123228	123228	NUM
eurjchem-2534	515	7	.	.	PUNCT
eurjchem-2534	516	1	[	[	X
eurjchem-2534	516	2	49	49	NUM
eurjchem-2534	516	3	]	]	PUNCT
eurjchem-2534	516	4	.	.	PUNCT
eurjchem-2534	517	1	tan	tan	PROPN
eurjchem-2534	517	2	,	,	PUNCT
eurjchem-2534	517	3	y.	y.	PROPN
eurjchem-2534	517	4	;	;	PUNCT
eurjchem-2534	517	5	zhu	zhu	PROPN
eurjchem-2534	517	6	,	,	PUNCT
eurjchem-2534	517	7	y.	y.	PROPN
eurjchem-2534	517	8	;	;	PUNCT
eurjchem-2534	517	9	zhao	zhao	PROPN
eurjchem-2534	517	10	,	,	PUNCT
eurjchem-2534	517	11	y.	y.	PROPN
eurjchem-2534	517	12	;	;	PUNCT
eurjchem-2534	517	13	wen	wen	PROPN
eurjchem-2534	517	14	,	,	PUNCT
eurjchem-2534	517	15	l.	l.	PROPN
eurjchem-2534	517	16	;	;	PUNCT
eurjchem-2534	517	17	meng	meng	PROPN
eurjchem-2534	517	18	,	,	PUNCT
eurjchem-2534	517	19	t.	t.	PROPN
eurjchem-2534	517	20	;	;	PUNCT
eurjchem-2534	517	21	liu	liu	PROPN
eurjchem-2534	517	22	,	,	PUNCT
eurjchem-2534	517	23	x.	x.	PROPN
eurjchem-2534	517	24	;	;	PUNCT
eurjchem-2534	517	25	yang	yang	PROPN
eurjchem-2534	517	26	,	,	PUNCT
eurjchem-2534	517	27	x.	x.	PROPN
eurjchem-2534	517	28	;	;	PUNCT
eurjchem-2534	517	29	dai	dai	PROPN
eurjchem-2534	517	30	,	,	PUNCT
eurjchem-2534	517	31	s.	s.	PROPN
eurjchem-2534	517	32	;	;	PUNCT
eurjchem-2534	517	33	yuan	yuan	PROPN
eurjchem-2534	517	34	,	,	PUNCT
eurjchem-2534	517	35	h.	h.	PROPN
eurjchem-2534	517	36	;	;	PUNCT
eurjchem-2534	517	37	hu	hu	PROPN
eurjchem-2534	517	38	,	,	PUNCT
eurjchem-2534	517	39	f.	f.	PROPN
eurjchem-2534	517	40	mitochondrial	mitochondrial	ADJ
eurjchem-2534	517	41	alkaline	alkaline	NOUN
eurjchem-2534	517	42	ph	ph	ADJ
eurjchem-2534	517	43	-	-	PUNCT
eurjchem-2534	517	44	responsive	responsive	ADJ
eurjchem-2534	517	45	drug	drug	NOUN
eurjchem-2534	517	46	release	release	NOUN
eurjchem-2534	517	47	mediated	mediate	VERB
eurjchem-2534	517	48	by	by	ADP
eurjchem-2534	517	49	celastrol	celastrol	NOUN
eurjchem-2534	517	50	loaded	load	VERB
eurjchem-2534	517	51	glycolipid	glycolipid	ADJ
eurjchem-2534	517	52	-	-	PUNCT
eurjchem-2534	517	53	like	like	ADJ
eurjchem-2534	517	54	micelles	micelle	NOUN
eurjchem-2534	517	55	for	for	ADP
eurjchem-2534	517	56	cancer	cancer	NOUN
eurjchem-2534	517	57	therapy	therapy	NOUN
eurjchem-2534	517	58	.	.	PUNCT
eurjchem-2534	518	1	biomaterials	biomaterial	NOUN
eurjchem-2534	518	2	2018	2018	NUM
eurjchem-2534	518	3	,	,	PUNCT
eurjchem-2534	518	4	154	154	NUM
eurjchem-2534	518	5	,	,	PUNCT
eurjchem-2534	518	6	169–181	169–181	NUM
eurjchem-2534	518	7	.	.	PUNCT
eurjchem-2534	519	1	[	[	X
eurjchem-2534	519	2	50	50	NUM
eurjchem-2534	519	3	]	]	PUNCT
eurjchem-2534	519	4	.	.	PUNCT
eurjchem-2534	520	1	niu	niu	PROPN
eurjchem-2534	520	2	,	,	PUNCT
eurjchem-2534	520	3	b.	b.	PROPN
eurjchem-2534	520	4	;	;	PUNCT
eurjchem-2534	520	5	wu	wu	PROPN
eurjchem-2534	520	6	,	,	PUNCT
eurjchem-2534	520	7	y.	y.	PROPN
eurjchem-2534	520	8	;	;	PUNCT
eurjchem-2534	520	9	zhou	zhou	PROPN
eurjchem-2534	520	10	,	,	PUNCT
eurjchem-2534	520	11	m.	m.	NOUN
eurjchem-2534	520	12	;	;	PUNCT
eurjchem-2534	520	13	lin	lin	PROPN
eurjchem-2534	520	14	,	,	PUNCT
eurjchem-2534	520	15	r.	r.	PROPN
eurjchem-2534	520	16	;	;	PUNCT
eurjchem-2534	520	17	ge	ge	PROPN
eurjchem-2534	520	18	,	,	PUNCT
eurjchem-2534	520	19	p.	p.	PROPN
eurjchem-2534	520	20	;	;	PUNCT
eurjchem-2534	520	21	chen	chen	PROPN
eurjchem-2534	520	22	,	,	PUNCT
eurjchem-2534	520	23	x.	x.	PROPN
eurjchem-2534	520	24	;	;	PUNCT
eurjchem-2534	520	25	zhou	zhou	PROPN
eurjchem-2534	520	26	,	,	PUNCT
eurjchem-2534	520	27	h.	h.	PROPN
eurjchem-2534	520	28	;	;	PUNCT
eurjchem-2534	520	29	zhang	zhang	PROPN
eurjchem-2534	520	30	,	,	PUNCT
eurjchem-2534	520	31	x.	x.	PROPN
eurjchem-2534	520	32	;	;	PUNCT
eurjchem-2534	520	33	xie	xie	PROPN
eurjchem-2534	520	34	,	,	PUNCT
eurjchem-2534	520	35	j.	j.	PROPN
eurjchem-2534	520	36	precise	precise	PROPN
eurjchem-2534	520	37	delivery	delivery	NOUN
eurjchem-2534	520	38	of	of	ADP
eurjchem-2534	520	39	celastrol	celastrol	NOUN
eurjchem-2534	520	40	by	by	ADP
eurjchem-2534	520	41	pegylated	pegylate	VERB
eurjchem-2534	520	42	aptamer	aptamer	NOUN
eurjchem-2534	520	43	dendrimer	dendrimer	NOUN
eurjchem-2534	520	44	nanoconjugates	nanoconjugate	NOUN
eurjchem-2534	520	45	for	for	ADP
eurjchem-2534	520	46	enormous	enormous	ADJ
eurjchem-2534	520	47	therapeutic	therapeutic	ADJ
eurjchem-2534	520	48	effect	effect	NOUN
eurjchem-2534	520	49	via	via	ADP
eurjchem-2534	520	50	superior	superior	ADJ
eurjchem-2534	520	51	intratumor	intratumor	ADJ
eurjchem-2534	520	52	penetration	penetration	NOUN
eurjchem-2534	520	53	over	over	ADP
eurjchem-2534	520	54	antibody	antibody	NOUN
eurjchem-2534	520	55	counterparts	counterpart	NOUN
eurjchem-2534	520	56	.	.	PUNCT
eurjchem-2534	521	1	cancer	cancer	NOUN
eurjchem-2534	521	2	lett	lett	PROPN
eurjchem-2534	521	3	.	.	PUNCT
eurjchem-2534	522	1	2023	2023	NUM
eurjchem-2534	522	2	,	,	PUNCT
eurjchem-2534	522	3	579	579	NUM
eurjchem-2534	522	4	,	,	PUNCT
eurjchem-2534	522	5	216461	216461	NUM
eurjchem-2534	522	6	.	.	PUNCT
eurjchem-2534	523	1	[	[	X
eurjchem-2534	523	2	51	51	NUM
eurjchem-2534	523	3	]	]	PUNCT
eurjchem-2534	523	4	.	.	PUNCT
eurjchem-2534	524	1	freag	freag	PROPN
eurjchem-2534	524	2	,	,	PUNCT
eurjchem-2534	524	3	m.	m.	NOUN
eurjchem-2534	524	4	s.	s.	PROPN
eurjchem-2534	524	5	;	;	PUNCT
eurjchem-2534	524	6	saleh	saleh	PROPN
eurjchem-2534	524	7	,	,	PUNCT
eurjchem-2534	524	8	w.	w.	PROPN
eurjchem-2534	524	9	m.	m.	PROPN
eurjchem-2534	524	10	;	;	PUNCT
eurjchem-2534	524	11	abdallah	abdallah	PROPN
eurjchem-2534	524	12	,	,	PUNCT
eurjchem-2534	524	13	o.	o.	PROPN
eurjchem-2534	524	14	y.	y.	PROPN
eurjchem-2534	524	15	self	self	NOUN
eurjchem-2534	524	16	-	-	PUNCT
eurjchem-2534	524	17	assembled	assemble	VERB
eurjchem-2534	524	18	phospholipidbased	phospholipidbase	VERB
eurjchem-2534	524	19	phytosomal	phytosomal	ADJ
eurjchem-2534	524	20	nanocarriers	nanocarrier	NOUN
eurjchem-2534	524	21	as	as	ADP
eurjchem-2534	524	22	promising	promise	VERB
eurjchem-2534	524	23	platforms	platform	NOUN
eurjchem-2534	524	24	for	for	ADP
eurjchem-2534	524	25	improving	improve	VERB
eurjchem-2534	524	26	oral	oral	ADJ
eurjchem-2534	524	27	bioavailability	bioavailability	NOUN
eurjchem-2534	524	28	of	of	ADP
eurjchem-2534	524	29	the	the	DET
eurjchem-2534	524	30	anticancer	anticancer	NOUN
eurjchem-2534	524	31	celastrol	celastrol	NOUN
eurjchem-2534	524	32	.	.	PUNCT
eurjchem-2534	525	1	int	int	NOUN
eurjchem-2534	525	2	.	.	PUNCT
eurjchem-2534	526	1	j.	j.	PROPN
eurjchem-2534	526	2	pharm	pharm	PROPN
eurjchem-2534	526	3	.	.	PUNCT
eurjchem-2534	527	1	2018	2018	NUM
eurjchem-2534	527	2	,	,	PUNCT
eurjchem-2534	527	3	535	535	NUM
eurjchem-2534	527	4	,	,	PUNCT
eurjchem-2534	527	5	18–26	18–26	NUM
eurjchem-2534	527	6	.	.	PUNCT
eurjchem-2534	528	1	[	[	X
eurjchem-2534	528	2	52	52	NUM
eurjchem-2534	528	3	]	]	PUNCT
eurjchem-2534	528	4	.	.	PUNCT
eurjchem-2534	529	1	fan	fan	PROPN
eurjchem-2534	529	2	,	,	PUNCT
eurjchem-2534	529	3	n.	n.	PROPN
eurjchem-2534	529	4	;	;	PUNCT
eurjchem-2534	529	5	zhao	zhao	PROPN
eurjchem-2534	529	6	,	,	PUNCT
eurjchem-2534	529	7	j.	j.	PROPN
eurjchem-2534	529	8	;	;	PUNCT
eurjchem-2534	529	9	zhao	zhao	PROPN
eurjchem-2534	529	10	,	,	PUNCT
eurjchem-2534	529	11	w.	w.	PROPN
eurjchem-2534	529	12	;	;	PUNCT
eurjchem-2534	529	13	shen	shen	PROPN
eurjchem-2534	529	14	,	,	PUNCT
eurjchem-2534	529	15	y.	y.	PROPN
eurjchem-2534	529	16	;	;	PUNCT
eurjchem-2534	529	17	song	song	PROPN
eurjchem-2534	529	18	,	,	PUNCT
eurjchem-2534	529	19	q.	q.	PROPN
eurjchem-2534	529	20	;	;	PUNCT
eurjchem-2534	529	21	shum	shum	X
eurjchem-2534	529	22	,	,	PUNCT
eurjchem-2534	529	23	h.	h.	PROPN
eurjchem-2534	529	24	c.	c.	PROPN
eurjchem-2534	529	25	;	;	PUNCT
eurjchem-2534	529	26	wang	wang	PROPN
eurjchem-2534	529	27	,	,	PUNCT
eurjchem-2534	529	28	y.	y.	PROPN
eurjchem-2534	529	29	;	;	PUNCT
eurjchem-2534	529	30	rong	rong	PROPN
eurjchem-2534	529	31	,	,	PUNCT
eurjchem-2534	529	32	j.	j.	PROPN
eurjchem-2534	529	33	biodegradable	biodegradable	ADJ
eurjchem-2534	529	34	celastrol	celastrol	NOUN
eurjchem-2534	529	35	-	-	PUNCT
eurjchem-2534	529	36	loaded	load	VERB
eurjchem-2534	529	37	albumin	albumin	ADJ
eurjchem-2534	529	38	nanoparticles	nanoparticle	NOUN
eurjchem-2534	529	39	ameliorate	ameliorate	VERB
eurjchem-2534	529	40	inflammation	inflammation	NOUN
eurjchem-2534	529	41	and	and	CCONJ
eurjchem-2534	529	42	lipid	lipid	NOUN
eurjchem-2534	529	43	accumulation	accumulation	NOUN
eurjchem-2534	529	44	in	in	ADP
eurjchem-2534	529	45	diet	diet	NOUN
eurjchem-2534	529	46	-	-	PUNCT
eurjchem-2534	529	47	induced	induce	VERB
eurjchem-2534	529	48	obese	obese	ADJ
eurjchem-2534	529	49	mice	mouse	NOUN
eurjchem-2534	529	50	.	.	PUNCT
eurjchem-2534	530	1	biomater	biomater	VERB
eurjchem-2534	530	2	.	.	PUNCT
eurjchem-2534	531	1	sci	sci	PROPN
eurjchem-2534	531	2	.	.	PROPN
eurjchem-2534	531	3	2022	2022	NUM
eurjchem-2534	531	4	,	,	PUNCT
eurjchem-2534	531	5	10	10	NUM
eurjchem-2534	531	6	,	,	PUNCT
eurjchem-2534	531	7	984–996	984–996	NUM
eurjchem-2534	531	8	.	.	PUNCT
eurjchem-2534	532	1	[	[	X
eurjchem-2534	532	2	53	53	NUM
eurjchem-2534	532	3	]	]	PUNCT
eurjchem-2534	532	4	.	.	PUNCT
eurjchem-2534	532	5	ozpolat	ozpolat	PROPN
eurjchem-2534	532	6	,	,	PUNCT
eurjchem-2534	532	7	b.	b.	PROPN
eurjchem-2534	532	8	;	;	PUNCT
eurjchem-2534	532	9	sood	sood	PROPN
eurjchem-2534	532	10	,	,	PUNCT
eurjchem-2534	532	11	a.	a.	PROPN
eurjchem-2534	532	12	k.	k.	PROPN
eurjchem-2534	532	13	;	;	PUNCT
eurjchem-2534	532	14	lopez	lopez	NOUN
eurjchem-2534	532	15	-	-	PUNCT
eurjchem-2534	532	16	berestein	berestein	PROPN
eurjchem-2534	532	17	,	,	PUNCT
eurjchem-2534	532	18	g.	g.	PROPN
eurjchem-2534	532	19	liposomal	liposomal	PROPN
eurjchem-2534	532	20	sirna	sirna	PROPN
eurjchem-2534	532	21	nanocarriers	nanocarrier	VERB
eurjchem-2534	532	22	for	for	ADP
eurjchem-2534	532	23	cancer	cancer	NOUN
eurjchem-2534	532	24	therapy	therapy	NOUN
eurjchem-2534	532	25	.	.	PUNCT
eurjchem-2534	533	1	adv	adv	PROPN
eurjchem-2534	533	2	.	.	PUNCT
eurjchem-2534	533	3	drug	drug	PROPN
eurjchem-2534	533	4	deliv	deliv	PROPN
eurjchem-2534	533	5	.	.	PUNCT
eurjchem-2534	534	1	rev	rev	PROPN
eurjchem-2534	534	2	.	.	PROPN
eurjchem-2534	534	3	2014	2014	NUM
eurjchem-2534	534	4	,	,	PUNCT
eurjchem-2534	534	5	66	66	NUM
eurjchem-2534	534	6	,	,	PUNCT
eurjchem-2534	534	7	110	110	NUM
eurjchem-2534	534	8	–	–	PUNCT
eurjchem-2534	534	9	116	116	NUM
eurjchem-2534	534	10	.	.	PUNCT
eurjchem-2534	535	1	[	[	X
eurjchem-2534	535	2	54	54	NUM
eurjchem-2534	535	3	]	]	PUNCT
eurjchem-2534	535	4	.	.	PUNCT
eurjchem-2534	536	1	chen	chen	PROPN
eurjchem-2534	536	2	,	,	PUNCT
eurjchem-2534	536	3	x.	x.	PROPN
eurjchem-2534	536	4	;	;	PUNCT
eurjchem-2534	536	5	hu	hu	PROPN
eurjchem-2534	536	6	,	,	PUNCT
eurjchem-2534	536	7	x.	x.	PROPN
eurjchem-2534	536	8	;	;	PUNCT
eurjchem-2534	536	9	hu	hu	PROPN
eurjchem-2534	536	10	,	,	PUNCT
eurjchem-2534	536	11	j.	j.	PROPN
eurjchem-2534	536	12	;	;	PUNCT
eurjchem-2534	536	13	qiu	qiu	PROPN
eurjchem-2534	536	14	,	,	PUNCT
eurjchem-2534	536	15	z.	z.	PROPN
eurjchem-2534	536	16	;	;	PUNCT
eurjchem-2534	536	17	yuan	yuan	NOUN
eurjchem-2534	536	18	,	,	PUNCT
eurjchem-2534	536	19	m.	m.	NOUN
eurjchem-2534	536	20	;	;	PUNCT
eurjchem-2534	536	21	zheng	zheng	PROPN
eurjchem-2534	536	22	,	,	PUNCT
eurjchem-2534	536	23	g.	g.	PROPN
eurjchem-2534	536	24	celastrol	celastrol	PROPN
eurjchem-2534	536	25	-	-	PUNCT
eurjchem-2534	536	26	loaded	load	VERB
eurjchem-2534	536	27	galactosylated	galactosylate	VERB
eurjchem-2534	536	28	liposomes	liposome	NOUN
eurjchem-2534	536	29	effectively	effectively	ADV
eurjchem-2534	536	30	inhibit	inhibit	VERB
eurjchem-2534	536	31	akt	akt	PROPN
eurjchem-2534	536	32	/	/	SYM
eurjchem-2534	536	33	c	c	X
eurjchem-2534	536	34	-	-	PUNCT
eurjchem-2534	536	35	met	meet	VERB
eurjchem-2534	536	36	-	-	PUNCT
eurjchem-2534	536	37	triggered	trigger	VERB
eurjchem-2534	536	38	rapid	rapid	ADJ
eurjchem-2534	536	39	hepatocarcinogenesis	hepatocarcinogenesis	NOUN
eurjchem-2534	536	40	in	in	ADP
eurjchem-2534	536	41	mice	mouse	NOUN
eurjchem-2534	536	42	.	.	PUNCT
eurjchem-2534	537	1	mol	mol	PROPN
eurjchem-2534	537	2	.	.	PUNCT
eurjchem-2534	537	3	pharm	pharm	PROPN
eurjchem-2534	537	4	.	.	PUNCT
eurjchem-2534	538	1	2020	2020	NUM
eurjchem-2534	538	2	,	,	PUNCT
eurjchem-2534	538	3	17	17	NUM
eurjchem-2534	538	4	,	,	PUNCT
eurjchem-2534	538	5	738–747	738–747	NUM
eurjchem-2534	538	6	.	.	PUNCT
eurjchem-2534	539	1	[	[	X
eurjchem-2534	539	2	55	55	NUM
eurjchem-2534	539	3	]	]	PUNCT
eurjchem-2534	539	4	.	.	PUNCT
eurjchem-2534	540	1	aqil	aqil	PROPN
eurjchem-2534	540	2	,	,	PUNCT
eurjchem-2534	540	3	f.	f.	PROPN
eurjchem-2534	540	4	;	;	PUNCT
eurjchem-2534	540	5	kausar	kausar	PROPN
eurjchem-2534	540	6	,	,	PUNCT
eurjchem-2534	540	7	h.	h.	PROPN
eurjchem-2534	540	8	;	;	PUNCT
eurjchem-2534	540	9	agrawal	agrawal	PROPN
eurjchem-2534	540	10	,	,	PUNCT
eurjchem-2534	540	11	a.	a.	PROPN
eurjchem-2534	540	12	k.	k.	PROPN
eurjchem-2534	540	13	;	;	PUNCT
eurjchem-2534	540	14	jeyabalan	jeyabalan	PROPN
eurjchem-2534	540	15	,	,	PUNCT
eurjchem-2534	540	16	j.	j.	PROPN
eurjchem-2534	540	17	;	;	PUNCT
eurjchem-2534	540	18	kyakulaga	kyakulaga	PROPN
eurjchem-2534	540	19	,	,	PUNCT
eurjchem-2534	540	20	a.-h	a.-h	PROPN
eurjchem-2534	540	21	.	.	PUNCT
eurjchem-2534	540	22	;	;	PUNCT
eurjchem-2534	540	23	munagala	munagala	PROPN
eurjchem-2534	540	24	,	,	PUNCT
eurjchem-2534	540	25	r.	r.	PROPN
eurjchem-2534	540	26	;	;	PUNCT
eurjchem-2534	540	27	gupta	gupta	PROPN
eurjchem-2534	540	28	,	,	PUNCT
eurjchem-2534	540	29	r.	r.	PROPN
eurjchem-2534	540	30	exosomal	exosomal	ADJ
eurjchem-2534	540	31	formulation	formulation	NOUN
eurjchem-2534	540	32	enhances	enhance	VERB
eurjchem-2534	540	33	therapeutic	therapeutic	ADJ
eurjchem-2534	540	34	response	response	NOUN
eurjchem-2534	540	35	of	of	ADP
eurjchem-2534	540	36	celastrol	celastrol	NOUN
eurjchem-2534	540	37	against	against	ADP
eurjchem-2534	540	38	lung	lung	NOUN
eurjchem-2534	540	39	cancer	cancer	NOUN
eurjchem-2534	540	40	.	.	PUNCT
eurjchem-2534	541	1	exp	exp	PROPN
eurjchem-2534	541	2	.	.	PROPN
eurjchem-2534	541	3	mol	mol	PROPN
eurjchem-2534	541	4	.	.	PROPN
eurjchem-2534	541	5	pathol	pathol	NOUN
eurjchem-2534	541	6	.	.	PUNCT
eurjchem-2534	542	1	2016	2016	NUM
eurjchem-2534	542	2	,	,	PUNCT
eurjchem-2534	542	3	101	101	NUM
eurjchem-2534	542	4	,	,	PUNCT
eurjchem-2534	542	5	12–21	12–21	NUM
eurjchem-2534	542	6	.	.	PUNCT
eurjchem-2534	543	1	[	[	X
eurjchem-2534	543	2	56	56	NUM
eurjchem-2534	543	3	]	]	PUNCT
eurjchem-2534	543	4	.	.	PUNCT
eurjchem-2534	544	1	zhao	zhao	PROPN
eurjchem-2534	544	2	,	,	PUNCT
eurjchem-2534	544	3	y.	y.	PROPN
eurjchem-2534	544	4	;	;	PUNCT
eurjchem-2534	544	5	tan	tan	PROPN
eurjchem-2534	544	6	,	,	PUNCT
eurjchem-2534	544	7	y.	y.	PROPN
eurjchem-2534	544	8	;	;	PUNCT
eurjchem-2534	544	9	meng	meng	PROPN
eurjchem-2534	544	10	,	,	PUNCT
eurjchem-2534	544	11	t.	t.	PROPN
eurjchem-2534	544	12	;	;	PUNCT
eurjchem-2534	544	13	liu	liu	PROPN
eurjchem-2534	544	14	,	,	PUNCT
eurjchem-2534	544	15	x.	x.	PROPN
eurjchem-2534	544	16	;	;	PUNCT
eurjchem-2534	544	17	zhu	zhu	PROPN
eurjchem-2534	544	18	,	,	PUNCT
eurjchem-2534	544	19	y.	y.	PROPN
eurjchem-2534	544	20	;	;	PUNCT
eurjchem-2534	544	21	hong	hong	PROPN
eurjchem-2534	544	22	,	,	PUNCT
eurjchem-2534	544	23	y.	y.	PROPN
eurjchem-2534	544	24	;	;	PUNCT
eurjchem-2534	544	25	yang	yang	PROPN
eurjchem-2534	544	26	,	,	PUNCT
eurjchem-2534	544	27	x.	x.	PROPN
eurjchem-2534	544	28	;	;	PUNCT
eurjchem-2534	544	29	yuan	yuan	PROPN
eurjchem-2534	544	30	,	,	PUNCT
eurjchem-2534	544	31	h.	h.	PROPN
eurjchem-2534	544	32	;	;	PUNCT
eurjchem-2534	544	33	huang	huang	PROPN
eurjchem-2534	544	34	,	,	PUNCT
eurjchem-2534	544	35	x.	x.	PROPN
eurjchem-2534	544	36	;	;	PUNCT
eurjchem-2534	544	37	hu	hu	PROPN
eurjchem-2534	544	38	,	,	PUNCT
eurjchem-2534	544	39	f.	f.	PROPN
eurjchem-2534	544	40	simultaneous	simultaneous	ADJ
eurjchem-2534	544	41	targeting	targeting	NOUN
eurjchem-2534	544	42	therapy	therapy	NOUN
eurjchem-2534	544	43	for	for	ADP
eurjchem-2534	544	44	lung	lung	NOUN
eurjchem-2534	544	45	metastasis	metastasis	NOUN
eurjchem-2534	544	46	and	and	CCONJ
eurjchem-2534	544	47	breast	breast	NOUN
eurjchem-2534	544	48	tumor	tumor	NOUN
eurjchem-2534	544	49	by	by	ADP
eurjchem-2534	544	50	blocking	block	VERB
eurjchem-2534	544	51	the	the	DET
eurjchem-2534	544	52	nf	nf	ADJ
eurjchem-2534	544	53	-	-	PUNCT
eurjchem-2534	544	54	κb	κb	NOUN
eurjchem-2534	544	55	signaling	signal	VERB
eurjchem-2534	544	56	pathway	pathway	NOUN
eurjchem-2534	544	57	using	use	VERB
eurjchem-2534	544	58	celastrol	celastrol	NOUN
eurjchem-2534	544	59	-	-	PUNCT
eurjchem-2534	544	60	loaded	load	VERB
eurjchem-2534	544	61	micelles	micelle	NOUN
eurjchem-2534	544	62	.	.	PUNCT
eurjchem-2534	545	1	drug	drug	NOUN
eurjchem-2534	545	2	deliv	deliv	NOUN
eurjchem-2534	545	3	.	.	PUNCT
eurjchem-2534	546	1	2018	2018	NUM
eurjchem-2534	546	2	,	,	PUNCT
eurjchem-2534	546	3	25	25	NUM
eurjchem-2534	546	4	,	,	PUNCT
eurjchem-2534	546	5	341–352	341–352	NUM
eurjchem-2534	546	6	.	.	PUNCT
eurjchem-2534	547	1	[	[	X
eurjchem-2534	547	2	57	57	NUM
eurjchem-2534	547	3	]	]	PUNCT
eurjchem-2534	547	4	.	.	PUNCT
eurjchem-2534	548	1	sanna	sanna	PROPN
eurjchem-2534	548	2	,	,	PUNCT
eurjchem-2534	548	3	v.	v.	ADV
eurjchem-2534	548	4	;	;	PUNCT
eurjchem-2534	548	5	chamcheu	chamcheu	PROPN
eurjchem-2534	548	6	,	,	PUNCT
eurjchem-2534	548	7	j.	j.	PROPN
eurjchem-2534	548	8	c.	c.	PROPN
eurjchem-2534	548	9	;	;	PUNCT
eurjchem-2534	548	10	pala	pala	PROPN
eurjchem-2534	548	11	,	,	PUNCT
eurjchem-2534	548	12	n.	n.	NOUN
eurjchem-2534	548	13	;	;	PUNCT
eurjchem-2534	548	14	mukhtar	mukhtar	PROPN
eurjchem-2534	548	15	,	,	PUNCT
eurjchem-2534	548	16	h.	h.	PROPN
eurjchem-2534	548	17	;	;	PUNCT
eurjchem-2534	548	18	sechi	sechi	PROPN
eurjchem-2534	548	19	,	,	PUNCT
eurjchem-2534	548	20	m.	m.	NOUN
eurjchem-2534	548	21	;	;	PUNCT
eurjchem-2534	548	22	siddiqui	siddiqui	NOUN
eurjchem-2534	548	23	,	,	PUNCT
eurjchem-2534	548	24	i.	i.	PROPN
eurjchem-2534	548	25	a.	a.	NOUN
eurjchem-2534	548	26	nanoencapsulation	nanoencapsulation	NOUN
eurjchem-2534	548	27	of	of	ADP
eurjchem-2534	548	28	natural	natural	ADJ
eurjchem-2534	548	29	triterpenoid	triterpenoid	NOUN
eurjchem-2534	548	30	celastrol	celastrol	NOUN
eurjchem-2534	548	31	for	for	ADP
eurjchem-2534	548	32	prostate	prostate	NOUN
eurjchem-2534	548	33	cancer	cancer	NOUN
eurjchem-2534	548	34	treatment	treatment	NOUN
eurjchem-2534	548	35	.	.	PUNCT
eurjchem-2534	549	1	int	int	NOUN
eurjchem-2534	549	2	.	.	PUNCT
eurjchem-2534	550	1	j.	j.	PROPN
eurjchem-2534	550	2	nanomedicine	nanomedicine	PROPN
eurjchem-2534	550	3	2015	2015	NUM
eurjchem-2534	550	4	,	,	PUNCT
eurjchem-2534	550	5	6835–6846	6835–6846	NUM
eurjchem-2534	550	6	.	.	PUNCT
eurjchem-2534	551	1	[	[	X
eurjchem-2534	551	2	58	58	NUM
eurjchem-2534	551	3	]	]	PUNCT
eurjchem-2534	551	4	.	.	PUNCT
eurjchem-2534	552	1	tian	tian	PROPN
eurjchem-2534	552	2	,	,	PUNCT
eurjchem-2534	552	3	q.	q.	PROPN
eurjchem-2534	552	4	;	;	PUNCT
eurjchem-2534	552	5	han	han	PROPN
eurjchem-2534	552	6	,	,	PUNCT
eurjchem-2534	552	7	q.	q.	PROPN
eurjchem-2534	552	8	;	;	PUNCT
eurjchem-2534	552	9	zhu	zhu	PROPN
eurjchem-2534	552	10	,	,	PUNCT
eurjchem-2534	552	11	x.	x.	PROPN
eurjchem-2534	552	12	;	;	PUNCT
eurjchem-2534	552	13	zhang	zhang	PROPN
eurjchem-2534	552	14	,	,	PUNCT
eurjchem-2534	552	15	l.	l.	PROPN
eurjchem-2534	552	16	;	;	PUNCT
eurjchem-2534	552	17	chen	chen	PROPN
eurjchem-2534	552	18	,	,	PUNCT
eurjchem-2534	552	19	k.	k.	PROPN
eurjchem-2534	552	20	;	;	PUNCT
eurjchem-2534	552	21	xie	xie	PROPN
eurjchem-2534	552	22	,	,	PUNCT
eurjchem-2534	552	23	z.	z.	PROPN
eurjchem-2534	552	24	;	;	PUNCT
eurjchem-2534	552	25	wang	wang	PROPN
eurjchem-2534	552	26	,	,	PUNCT
eurjchem-2534	552	27	p.	p.	PROPN
eurjchem-2534	552	28	;	;	PUNCT
eurjchem-2534	552	29	wu	wu	PROPN
eurjchem-2534	552	30	,	,	PUNCT
eurjchem-2534	552	31	x.	x.	PROPN
eurjchem-2534	552	32	;	;	PUNCT
eurjchem-2534	552	33	zhang	zhang	PROPN
eurjchem-2534	552	34	,	,	PUNCT
eurjchem-2534	552	35	z.	z.	PROPN
eurjchem-2534	552	36	;	;	PUNCT
eurjchem-2534	552	37	zeng	zeng	PROPN
eurjchem-2534	552	38	,	,	PUNCT
eurjchem-2534	552	39	h.	h.	PROPN
eurjchem-2534	552	40	celastrol	celastrol	PROPN
eurjchem-2534	552	41	-	-	PUNCT
eurjchem-2534	552	42	conjugated	conjugate	VERB
eurjchem-2534	552	43	carboxylmethyl	carboxylmethyl	PROPN
eurjchem-2534	552	44	chitosan	chitosan	PROPN
eurjchem-2534	552	45	for	for	ADP
eurjchem-2534	552	46	oral	oral	ADJ
eurjchem-2534	552	47	treatment	treatment	NOUN
eurjchem-2534	552	48	of	of	ADP
eurjchem-2534	552	49	diet	diet	NOUN
eurjchem-2534	552	50	-	-	PUNCT
eurjchem-2534	552	51	induced	induce	VERB
eurjchem-2534	552	52	obesity	obesity	NOUN
eurjchem-2534	552	53	.	.	PUNCT
eurjchem-2534	553	1	j.	j.	PROPN
eurjchem-2534	553	2	drug	drug	PROPN
eurjchem-2534	553	3	deliv	deliv	PROPN
eurjchem-2534	553	4	.	.	PUNCT
eurjchem-2534	554	1	sci	sci	PROPN
eurjchem-2534	554	2	.	.	PROPN
eurjchem-2534	554	3	technol	technol	PROPN
eurjchem-2534	554	4	.	.	PROPN
eurjchem-2534	554	5	2021	2021	NUM
eurjchem-2534	554	6	,	,	PUNCT
eurjchem-2534	554	7	62	62	NUM
eurjchem-2534	554	8	,	,	PUNCT
eurjchem-2534	554	9	102408	102408	NUM
eurjchem-2534	554	10	.	.	PUNCT
eurjchem-2534	555	1	[	[	X
eurjchem-2534	555	2	59	59	NUM
eurjchem-2534	555	3	]	]	PUNCT
eurjchem-2534	555	4	.	.	PUNCT
eurjchem-2534	555	5	boridy	boridy	PROPN
eurjchem-2534	555	6	,	,	PUNCT
eurjchem-2534	555	7	s.	s.	PROPN
eurjchem-2534	555	8	;	;	PUNCT
eurjchem-2534	555	9	soliman	soliman	PROPN
eurjchem-2534	555	10	,	,	PUNCT
eurjchem-2534	555	11	g.	g.	PROPN
eurjchem-2534	555	12	m.	m.	PROPN
eurjchem-2534	555	13	;	;	PUNCT
eurjchem-2534	555	14	maysinger	maysinger	NOUN
eurjchem-2534	555	15	,	,	PUNCT
eurjchem-2534	555	16	d.	d.	PROPN
eurjchem-2534	555	17	modulation	modulation	NOUN
eurjchem-2534	555	18	of	of	ADP
eurjchem-2534	555	19	inflammatory	inflammatory	ADJ
eurjchem-2534	555	20	signaling	signal	VERB
eurjchem-2534	555	21	and	and	CCONJ
eurjchem-2534	555	22	cytokine	cytokine	ADJ
eurjchem-2534	555	23	release	release	NOUN
eurjchem-2534	555	24	from	from	ADP
eurjchem-2534	555	25	microglia	microglia	NOUN
eurjchem-2534	555	26	by	by	ADP
eurjchem-2534	555	27	celastrol	celastrol	NOUN
eurjchem-2534	555	28	incorporated	incorporate	VERB
eurjchem-2534	555	29	into	into	ADP
eurjchem-2534	555	30	dendrimer	dendrimer	NOUN
eurjchem-2534	555	31	nanocarriers	nanocarrier	NOUN
eurjchem-2534	555	32	.	.	PUNCT
eurjchem-2534	556	1	nanomedicine	nanomedicine	NOUN
eurjchem-2534	556	2	(	(	PUNCT
eurjchem-2534	556	3	lond	lond	PROPN
eurjchem-2534	556	4	.	.	PUNCT
eurjchem-2534	556	5	)	)	PUNCT
eurjchem-2534	556	6	2012	2012	NUM
eurjchem-2534	556	7	,	,	PUNCT
eurjchem-2534	556	8	7	7	NUM
eurjchem-2534	556	9	,	,	PUNCT
eurjchem-2534	556	10	1149–1165	1149–1165	NUM
eurjchem-2534	556	11	.	.	PUNCT
eurjchem-2534	557	1	[	[	X
eurjchem-2534	557	2	60	60	NUM
eurjchem-2534	557	3	]	]	PUNCT
eurjchem-2534	557	4	.	.	PUNCT
eurjchem-2534	558	1	gong	gong	PROPN
eurjchem-2534	558	2	,	,	PUNCT
eurjchem-2534	558	3	t.	t.	PROPN
eurjchem-2534	558	4	;	;	PUNCT
eurjchem-2534	558	5	zhang	zhang	PROPN
eurjchem-2534	558	6	,	,	PUNCT
eurjchem-2534	558	7	p.	p.	PROPN
eurjchem-2534	558	8	;	;	PUNCT
eurjchem-2534	558	9	deng	deng	PROPN
eurjchem-2534	558	10	,	,	PUNCT
eurjchem-2534	558	11	c.	c.	PROPN
eurjchem-2534	558	12	;	;	PUNCT
eurjchem-2534	558	13	xiao	xiao	PROPN
eurjchem-2534	558	14	,	,	PUNCT
eurjchem-2534	558	15	y.	y.	PROPN
eurjchem-2534	558	16	;	;	PUNCT
eurjchem-2534	558	17	gong	gong	NOUN
eurjchem-2534	558	18	,	,	PUNCT
eurjchem-2534	558	19	t.	t.	PROPN
eurjchem-2534	558	20	;	;	PUNCT
eurjchem-2534	558	21	zhang	zhang	PROPN
eurjchem-2534	558	22	,	,	PUNCT
eurjchem-2534	558	23	z.	z.	PROPN
eurjchem-2534	559	1	an	an	DET
eurjchem-2534	559	2	effective	effective	ADJ
eurjchem-2534	559	3	and	and	CCONJ
eurjchem-2534	559	4	safe	safe	ADJ
eurjchem-2534	559	5	treatment	treatment	NOUN
eurjchem-2534	559	6	strategy	strategy	NOUN
eurjchem-2534	559	7	for	for	ADP
eurjchem-2534	559	8	rheumatoid	rheumatoid	NOUN
eurjchem-2534	559	9	arthritis	arthritis	NOUN
eurjchem-2534	559	10	based	base	VERB
eurjchem-2534	559	11	on	on	ADP
eurjchem-2534	559	12	human	human	ADJ
eurjchem-2534	559	13	serum	serum	NOUN
eurjchem-2534	559	14	albumin	albumin	PROPN
eurjchem-2534	559	15	and	and	CCONJ
eurjchem-2534	559	16	kolliphor	kolliphor	PROPN
eurjchem-2534	559	17	®	®	NOUN
eurjchem-2534	559	18	hs	hs	PROPN
eurjchem-2534	559	19	15	15	NUM
eurjchem-2534	559	20	.	.	PUNCT
eurjchem-2534	560	1	nanomedicine	nanomedicine	NOUN
eurjchem-2534	560	2	(	(	PUNCT
eurjchem-2534	560	3	lond	lond	PROPN
eurjchem-2534	560	4	.	.	PUNCT
eurjchem-2534	560	5	)	)	PUNCT
eurjchem-2534	560	6	2019	2019	NUM
eurjchem-2534	560	7	,	,	PUNCT
eurjchem-2534	560	8	14	14	NUM
eurjchem-2534	560	9	,	,	PUNCT
eurjchem-2534	560	10	2169–2187	2169–2187	NUM
eurjchem-2534	560	11	.	.	PUNCT
eurjchem-2534	561	1	[	[	X
eurjchem-2534	561	2	61	61	NUM
eurjchem-2534	561	3	]	]	PUNCT
eurjchem-2534	561	4	.	.	PUNCT
eurjchem-2534	562	1	fan	fan	PROPN
eurjchem-2534	562	2	,	,	PUNCT
eurjchem-2534	562	3	n.	n.	PROPN
eurjchem-2534	562	4	;	;	PUNCT
eurjchem-2534	562	5	zhao	zhao	PROPN
eurjchem-2534	562	6	,	,	PUNCT
eurjchem-2534	562	7	j.	j.	PROPN
eurjchem-2534	562	8	;	;	PUNCT
eurjchem-2534	562	9	zhao	zhao	PROPN
eurjchem-2534	562	10	,	,	PUNCT
eurjchem-2534	562	11	w.	w.	PROPN
eurjchem-2534	562	12	;	;	PUNCT
eurjchem-2534	562	13	zhang	zhang	PROPN
eurjchem-2534	562	14	,	,	PUNCT
eurjchem-2534	562	15	x.	x.	PROPN
eurjchem-2534	562	16	;	;	PUNCT
eurjchem-2534	562	17	song	song	PROPN
eurjchem-2534	562	18	,	,	PUNCT
eurjchem-2534	562	19	q.	q.	PROPN
eurjchem-2534	562	20	;	;	PUNCT
eurjchem-2534	562	21	shen	shen	PROPN
eurjchem-2534	562	22	,	,	PUNCT
eurjchem-2534	562	23	y.	y.	PROPN
eurjchem-2534	562	24	;	;	PUNCT
eurjchem-2534	562	25	shum	shum	X
eurjchem-2534	562	26	,	,	PUNCT
eurjchem-2534	562	27	h.	h.	PROPN
eurjchem-2534	562	28	c.	c.	PROPN
eurjchem-2534	562	29	;	;	PUNCT
eurjchem-2534	562	30	wang	wang	PROPN
eurjchem-2534	562	31	,	,	PUNCT
eurjchem-2534	562	32	y.	y.	PROPN
eurjchem-2534	562	33	;	;	PUNCT
eurjchem-2534	562	34	rong	rong	PROPN
eurjchem-2534	562	35	,	,	PUNCT
eurjchem-2534	562	36	j.	j.	PROPN
eurjchem-2534	562	37	celastrol	celastrol	PROPN
eurjchem-2534	562	38	-	-	PUNCT
eurjchem-2534	562	39	loaded	load	VERB
eurjchem-2534	562	40	lactosylated	lactosylate	VERB
eurjchem-2534	562	41	albumin	albumin	ADJ
eurjchem-2534	562	42	nanoparticles	nanoparticle	NOUN
eurjchem-2534	562	43	attenuate	attenuate	VERB
eurjchem-2534	562	44	hepatic	hepatic	ADJ
eurjchem-2534	562	45	steatosis	steatosis	NOUN
eurjchem-2534	562	46	in	in	ADP
eurjchem-2534	562	47	non	non	ADJ
eurjchem-2534	562	48	-	-	ADJ
eurjchem-2534	562	49	alcoholic	alcoholic	ADJ
eurjchem-2534	562	50	fatty	fatty	NOUN
eurjchem-2534	562	51	liver	liver	NOUN
eurjchem-2534	562	52	disease	disease	NOUN
eurjchem-2534	562	53	.	.	PUNCT
eurjchem-2534	563	1	j.	j.	PROPN
eurjchem-2534	563	2	control	control	PROPN
eurjchem-2534	563	3	.	.	PUNCT
eurjchem-2534	564	1	release	release	VERB
eurjchem-2534	564	2	2022	2022	NUM
eurjchem-2534	564	3	,	,	PUNCT
eurjchem-2534	564	4	347	347	NUM
eurjchem-2534	564	5	,	,	PUNCT
eurjchem-2534	564	6	44–54	44–54	NUM
eurjchem-2534	564	7	.	.	PUNCT
eurjchem-2534	565	1	[	[	X
eurjchem-2534	565	2	62	62	NUM
eurjchem-2534	565	3	]	]	PUNCT
eurjchem-2534	565	4	.	.	PUNCT
eurjchem-2534	566	1	zhu	zhu	PROPN
eurjchem-2534	566	2	,	,	PUNCT
eurjchem-2534	566	3	s.	s.	PROPN
eurjchem-2534	566	4	;	;	PUNCT
eurjchem-2534	566	5	luo	luo	PROPN
eurjchem-2534	566	6	,	,	PUNCT
eurjchem-2534	566	7	c.	c.	PROPN
eurjchem-2534	566	8	;	;	PUNCT
eurjchem-2534	566	9	feng	feng	PROPN
eurjchem-2534	566	10	,	,	PUNCT
eurjchem-2534	566	11	w.	w.	PROPN
eurjchem-2534	566	12	;	;	PUNCT
eurjchem-2534	566	13	li	li	PROPN
eurjchem-2534	566	14	,	,	PUNCT
eurjchem-2534	566	15	y.	y.	PROPN
eurjchem-2534	566	16	;	;	PUNCT
eurjchem-2534	566	17	zhu	zhu	PROPN
eurjchem-2534	566	18	,	,	PUNCT
eurjchem-2534	566	19	m.	m.	NOUN
eurjchem-2534	566	20	;	;	PUNCT
eurjchem-2534	566	21	sun	sun	NOUN
eurjchem-2534	566	22	,	,	PUNCT
eurjchem-2534	566	23	s.	s.	PROPN
eurjchem-2534	566	24	;	;	PUNCT
eurjchem-2534	566	25	zhang	zhang	PROPN
eurjchem-2534	566	26	,	,	PUNCT
eurjchem-2534	566	27	x.	x.	PROPN
eurjchem-2534	566	28	seleniumdeposited	seleniumdeposite	VERB
eurjchem-2534	566	29	tripterine	tripterine	ADJ
eurjchem-2534	566	30	phytosomes	phytosome	NOUN
eurjchem-2534	566	31	ameliorate	ameliorate	VERB
eurjchem-2534	566	32	the	the	DET
eurjchem-2534	566	33	antiarthritic	antiarthritic	ADJ
eurjchem-2534	566	34	efficacy	efficacy	NOUN
eurjchem-2534	566	35	of	of	ADP
eurjchem-2534	566	36	the	the	DET
eurjchem-2534	566	37	phytomedicine	phytomedicine	NOUN
eurjchem-2534	566	38	via	via	ADP
eurjchem-2534	566	39	a	a	DET
eurjchem-2534	566	40	synergistic	synergistic	ADJ
eurjchem-2534	566	41	sensitization	sensitization	NOUN
eurjchem-2534	566	42	.	.	PUNCT
eurjchem-2534	567	1	int	int	NOUN
eurjchem-2534	567	2	.	.	PUNCT
eurjchem-2534	568	1	j.	j.	PROPN
eurjchem-2534	568	2	pharm	pharm	PROPN
eurjchem-2534	568	3	.	.	PUNCT
eurjchem-2534	569	1	2020	2020	NUM
eurjchem-2534	569	2	,	,	PUNCT
eurjchem-2534	569	3	578	578	NUM
eurjchem-2534	569	4	,	,	PUNCT
eurjchem-2534	569	5	119104	119104	NUM
eurjchem-2534	569	6	.	.	PUNCT
eurjchem-2534	570	1	[	[	X
eurjchem-2534	570	2	63	63	NUM
eurjchem-2534	570	3	]	]	PUNCT
eurjchem-2534	570	4	.	.	PUNCT
eurjchem-2534	571	1	liu	liu	PROPN
eurjchem-2534	571	2	,	,	PUNCT
eurjchem-2534	571	3	s.	s.	PROPN
eurjchem-2534	571	4	;	;	PUNCT
eurjchem-2534	571	5	chen	chen	PROPN
eurjchem-2534	571	6	,	,	PUNCT
eurjchem-2534	571	7	q.	q.	PROPN
eurjchem-2534	571	8	;	;	PUNCT
eurjchem-2534	571	9	yan	yan	PROPN
eurjchem-2534	571	10	,	,	PUNCT
eurjchem-2534	571	11	l.	l.	PROPN
eurjchem-2534	571	12	;	;	PUNCT
eurjchem-2534	571	13	ren	ren	PROPN
eurjchem-2534	571	14	,	,	PUNCT
eurjchem-2534	571	15	y.	y.	PROPN
eurjchem-2534	571	16	;	;	PUNCT
eurjchem-2534	571	17	fan	fan	PROPN
eurjchem-2534	571	18	,	,	PUNCT
eurjchem-2534	571	19	j.	j.	PROPN
eurjchem-2534	571	20	;	;	PUNCT
eurjchem-2534	571	21	zhang	zhang	PROPN
eurjchem-2534	571	22	,	,	PUNCT
eurjchem-2534	571	23	x.	x.	PROPN
eurjchem-2534	571	24	;	;	PUNCT
eurjchem-2534	571	25	zhu	zhu	PROPN
eurjchem-2534	571	26	,	,	PUNCT
eurjchem-2534	571	27	s.	s.	PROPN
eurjchem-2534	571	28	phytosomal	phytosomal	PROPN
eurjchem-2534	571	29	tripterine	tripterine	VERB
eurjchem-2534	571	30	with	with	ADP
eurjchem-2534	571	31	selenium	selenium	NOUN
eurjchem-2534	571	32	modification	modification	NOUN
eurjchem-2534	571	33	attenuates	attenuate	VERB
eurjchem-2534	571	34	the	the	DET
eurjchem-2534	571	35	cytotoxicity	cytotoxicity	NOUN
eurjchem-2534	571	36	and	and	CCONJ
eurjchem-2534	571	37	restrains	restrain	VERB
eurjchem-2534	571	38	the	the	DET
eurjchem-2534	571	39	inflammatory	inflammatory	ADJ
eurjchem-2534	571	40	evolution	evolution	NOUN
eurjchem-2534	571	41	via	via	ADP
eurjchem-2534	571	42	inhibiting	inhibit	VERB
eurjchem-2534	571	43	nlrp3	nlrp3	NOUN
eurjchem-2534	571	44	inflammasome	inflammasome	NOUN
eurjchem-2534	571	45	activation	activation	NOUN
eurjchem-2534	571	46	and	and	CCONJ
eurjchem-2534	571	47	pyroptosis	pyroptosis	NOUN
eurjchem-2534	571	48	.	.	PUNCT
eurjchem-2534	572	1	int	int	NOUN
eurjchem-2534	572	2	.	.	PUNCT
eurjchem-2534	573	1	immunopharmacol	immunopharmacol	PROPN
eurjchem-2534	573	2	.	.	PROPN
eurjchem-2534	573	3	2022	2022	NUM
eurjchem-2534	573	4	,	,	PUNCT
eurjchem-2534	573	5	108	108	NUM
eurjchem-2534	573	6	,	,	PUNCT
eurjchem-2534	573	7	108871	108871	NUM
eurjchem-2534	573	8	.	.	PUNCT
eurjchem-2534	574	1	[	[	X
eurjchem-2534	574	2	64	64	NUM
eurjchem-2534	574	3	]	]	PUNCT
eurjchem-2534	574	4	.	.	PUNCT
eurjchem-2534	575	1	luo	luo	PROPN
eurjchem-2534	575	2	,	,	PUNCT
eurjchem-2534	575	3	p.	p.	PROPN
eurjchem-2534	575	4	;	;	PUNCT
eurjchem-2534	575	5	zhang	zhang	PROPN
eurjchem-2534	575	6	,	,	PUNCT
eurjchem-2534	575	7	q.	q.	PROPN
eurjchem-2534	575	8	;	;	PUNCT
eurjchem-2534	575	9	shen	shen	PROPN
eurjchem-2534	575	10	,	,	PUNCT
eurjchem-2534	575	11	s.	s.	PROPN
eurjchem-2534	575	12	;	;	PUNCT
eurjchem-2534	575	13	an	an	PRON
eurjchem-2534	575	14	,	,	PUNCT
eurjchem-2534	575	15	y.	y.	PROPN
eurjchem-2534	575	16	;	;	PUNCT
eurjchem-2534	575	17	yuan	yuan	PROPN
eurjchem-2534	575	18	,	,	PUNCT
eurjchem-2534	575	19	l.	l.	PROPN
eurjchem-2534	575	20	;	;	PUNCT
eurjchem-2534	575	21	wong	wong	PROPN
eurjchem-2534	575	22	,	,	PUNCT
eurjchem-2534	575	23	y.-k	y.-k	PROPN
eurjchem-2534	575	24	.	.	PUNCT
eurjchem-2534	575	25	;	;	PUNCT
eurjchem-2534	575	26	huang	huang	PROPN
eurjchem-2534	575	27	,	,	PUNCT
eurjchem-2534	575	28	s.	s.	PROPN
eurjchem-2534	575	29	;	;	PUNCT
eurjchem-2534	575	30	huang	huang	PROPN
eurjchem-2534	575	31	,	,	PUNCT
eurjchem-2534	575	32	s.	s.	PROPN
eurjchem-2534	575	33	;	;	PUNCT
eurjchem-2534	575	34	huang	huang	PROPN
eurjchem-2534	575	35	,	,	PUNCT
eurjchem-2534	575	36	j.	j.	PROPN
eurjchem-2534	575	37	;	;	PUNCT
eurjchem-2534	575	38	cheng	cheng	PROPN
eurjchem-2534	575	39	,	,	PUNCT
eurjchem-2534	575	40	g.	g.	PROPN
eurjchem-2534	575	41	;	;	PUNCT
eurjchem-2534	575	42	tian	tian	PROPN
eurjchem-2534	575	43	,	,	PUNCT
eurjchem-2534	575	44	j.	j.	PROPN
eurjchem-2534	575	45	;	;	PUNCT
eurjchem-2534	575	46	chen	chen	PROPN
eurjchem-2534	575	47	,	,	PUNCT
eurjchem-2534	575	48	y.	y.	PROPN
eurjchem-2534	575	49	;	;	PUNCT
eurjchem-2534	575	50	zhang	zhang	PROPN
eurjchem-2534	575	51	,	,	PUNCT
eurjchem-2534	575	52	x.	x.	PROPN
eurjchem-2534	575	53	;	;	PUNCT
eurjchem-2534	575	54	li	li	PROPN
eurjchem-2534	575	55	,	,	PUNCT
eurjchem-2534	575	56	w.	w.	PROPN
eurjchem-2534	575	57	;	;	PUNCT
eurjchem-2534	575	58	he	he	PRON
eurjchem-2534	575	59	,	,	PUNCT
eurjchem-2534	575	60	s.	s.	PROPN
eurjchem-2534	575	61	;	;	PUNCT
eurjchem-2534	575	62	wang	wang	PROPN
eurjchem-2534	575	63	,	,	PUNCT
eurjchem-2534	575	64	j.	j.	PROPN
eurjchem-2534	575	65	;	;	PUNCT
eurjchem-2534	575	66	du	du	PROPN
eurjchem-2534	575	67	,	,	PUNCT
eurjchem-2534	575	68	q.	q.	PROPN
eurjchem-2534	575	69	mechanistic	mechanistic	ADJ
eurjchem-2534	575	70	engineering	engineering	NOUN
eurjchem-2534	575	71	of	of	ADP
eurjchem-2534	575	72	celastrol	celastrol	NOUN
eurjchem-2534	575	73	liposomes	liposome	NOUN
eurjchem-2534	575	74	induces	induce	VERB
eurjchem-2534	575	75	ferroptosis	ferroptosis	NOUN
eurjchem-2534	575	76	and	and	CCONJ
eurjchem-2534	575	77	apoptosis	apoptosis	NOUN
eurjchem-2534	575	78	by	by	ADP
eurjchem-2534	575	79	directly	directly	ADV
eurjchem-2534	575	80	targeting	target	VERB
eurjchem-2534	575	81	vdac2	vdac2	NOUN
eurjchem-2534	575	82	in	in	ADP
eurjchem-2534	575	83	hepatocellular	hepatocellular	ADJ
eurjchem-2534	575	84	carcinoma	carcinoma	NOUN
eurjchem-2534	575	85	.	.	PUNCT
eurjchem-2534	576	1	asian	asian	PROPN
eurjchem-2534	576	2	j.	j.	PROPN
eurjchem-2534	576	3	pharm	pharm	PROPN
eurjchem-2534	576	4	.	.	PUNCT
eurjchem-2534	577	1	sci	sci	PROPN
eurjchem-2534	577	2	.	.	PROPN
eurjchem-2534	577	3	2023	2023	NUM
eurjchem-2534	577	4	,	,	PUNCT
eurjchem-2534	577	5	18	18	NUM
eurjchem-2534	577	6	,	,	PUNCT
eurjchem-2534	577	7	100874	100874	NUM
eurjchem-2534	577	8	.	.	PUNCT
eurjchem-2534	578	1	[	[	X
eurjchem-2534	578	2	65	65	NUM
eurjchem-2534	578	3	]	]	PUNCT
eurjchem-2534	578	4	.	.	PUNCT
eurjchem-2534	579	1	zheng	zheng	PROPN
eurjchem-2534	579	2	,	,	PUNCT
eurjchem-2534	579	3	x.	x.	PROPN
eurjchem-2534	579	4	;	;	PUNCT
eurjchem-2534	579	5	xing	xing	PROPN
eurjchem-2534	579	6	,	,	PUNCT
eurjchem-2534	579	7	y.	y.	PROPN
eurjchem-2534	579	8	;	;	PUNCT
eurjchem-2534	579	9	sun	sun	PROPN
eurjchem-2534	579	10	,	,	PUNCT
eurjchem-2534	579	11	k.	k.	PROPN
eurjchem-2534	579	12	;	;	PUNCT
eurjchem-2534	579	13	jin	jin	PROPN
eurjchem-2534	579	14	,	,	PUNCT
eurjchem-2534	579	15	h.	h.	PROPN
eurjchem-2534	579	16	;	;	PUNCT
eurjchem-2534	579	17	zhao	zhao	PROPN
eurjchem-2534	579	18	,	,	PUNCT
eurjchem-2534	579	19	w.	w.	PROPN
eurjchem-2534	579	20	;	;	PUNCT
eurjchem-2534	579	21	yu	yu	PROPN
eurjchem-2534	579	22	,	,	PUNCT
eurjchem-2534	579	23	f.	f.	PROPN
eurjchem-2534	579	24	combination	combination	NOUN
eurjchem-2534	579	25	therapy	therapy	NOUN
eurjchem-2534	579	26	with	with	ADP
eurjchem-2534	579	27	resveratrol	resveratrol	NOUN
eurjchem-2534	579	28	and	and	CCONJ
eurjchem-2534	579	29	celastrol	celastrol	NOUN
eurjchem-2534	579	30	using	use	VERB
eurjchem-2534	579	31	folic	folic	ADJ
eurjchem-2534	579	32	acid	acid	NOUN
eurjchem-2534	579	33	-	-	PUNCT
eurjchem-2534	579	34	functionalized	functionalize	VERB
eurjchem-2534	579	35	exosomes	exosome	NOUN
eurjchem-2534	579	36	enhances	enhance	VERB
eurjchem-2534	579	37	the	the	DET
eurjchem-2534	579	38	therapeutic	therapeutic	ADJ
eurjchem-2534	579	39	efficacy	efficacy	NOUN
eurjchem-2534	579	40	of	of	ADP
eurjchem-2534	579	41	sepsis	sepsis	NOUN
eurjchem-2534	579	42	.	.	PUNCT
eurjchem-2534	580	1	adv	adv	PROPN
eurjchem-2534	580	2	.	.	PUNCT
eurjchem-2534	580	3	healthc	healthc	PROPN
eurjchem-2534	580	4	.	.	PUNCT
eurjchem-2534	581	1	mater	mater	PROPN
eurjchem-2534	581	2	.	.	PUNCT
eurjchem-2534	582	1	2023	2023	NUM
eurjchem-2534	582	2	,	,	PUNCT
eurjchem-2534	582	3	12	12	NUM
eurjchem-2534	582	4	,	,	PUNCT
eurjchem-2534	582	5	e2301325	e2301325	PROPN
eurjchem-2534	582	6	.	.	PUNCT
eurjchem-2534	583	1	[	[	X
eurjchem-2534	583	2	66	66	NUM
eurjchem-2534	583	3	]	]	PUNCT
eurjchem-2534	583	4	.	.	PUNCT
eurjchem-2534	584	1	effect	effect	NOUN
eurjchem-2534	584	2	of	of	ADP
eurjchem-2534	584	3	different	different	ADJ
eurjchem-2534	584	4	ingestion	ingestion	NOUN
eurjchem-2534	584	5	doses	dose	NOUN
eurjchem-2534	584	6	of	of	ADP
eurjchem-2534	584	7	celastrol	celastrol	NOUN
eurjchem-2534	584	8	on	on	ADP
eurjchem-2534	584	9	human	human	ADJ
eurjchem-2534	584	10	sperm	sperm	NOUN
eurjchem-2534	584	11	motility	motility	NOUN
eurjchem-2534	584	12	clinicaltrials.gov	clinicaltrials.gov	PROPN
eurjchem-2534	584	13	.	.	X
eurjchem-2534	585	1	https://clinicaltrials.gov/study/	https://clinicaltrials.gov/study/	X
eurjchem-2534	585	2	nct05413226	nct05413226	PROPN
eurjchem-2534	585	3	(	(	PUNCT
eurjchem-2534	585	4	accessed	access	VERB
eurjchem-2534	585	5	jan	jan	PROPN
eurjchem-2534	585	6	11	11	NUM
eurjchem-2534	585	7	,	,	PUNCT
eurjchem-2534	585	8	2024	2024	NUM
eurjchem-2534	585	9	)	)	PUNCT
eurjchem-2534	585	10	.	.	PUNCT
eurjchem-2534	586	1	[	[	X
eurjchem-2534	586	2	67	67	NUM
eurjchem-2534	586	3	]	]	PUNCT
eurjchem-2534	586	4	.	.	PUNCT
eurjchem-2534	587	1	a	a	DET
eurjchem-2534	587	2	sub	sub	ADJ
eurjchem-2534	587	3	-	-	ADJ
eurjchem-2534	587	4	chronic	chronic	ADJ
eurjchem-2534	587	5	evaluation	evaluation	NOUN
eurjchem-2534	587	6	of	of	ADP
eurjchem-2534	587	7	the	the	DET
eurjchem-2534	587	8	safety	safety	NOUN
eurjchem-2534	587	9	of	of	ADP
eurjchem-2534	587	10	celastrol	celastrol	NOUN
eurjchem-2534	587	11	in	in	ADP
eurjchem-2534	587	12	human	human	ADJ
eurjchem-2534	587	13	subjects	subject	NOUN
eurjchem-2534	587	14	clinicaltrials.gov	clinicaltrials.gov	X
eurjchem-2534	587	15	.	.	PUNCT
eurjchem-2534	588	1	https://clinicaltrials.gov/study/nct05494112	https://clinicaltrials.gov/study/nct05494112	PROPN
eurjchem-2534	588	2	(	(	PUNCT
eurjchem-2534	588	3	accessed	access	VERB
eurjchem-2534	588	4	jan	jan	PROPN
eurjchem-2534	588	5	11	11	NUM
eurjchem-2534	588	6	,	,	PUNCT
eurjchem-2534	588	7	2024	2024	NUM
eurjchem-2534	588	8	)	)	PUNCT
eurjchem-2534	588	9	.	.	PUNCT
eurjchem-2534	589	1	[	[	X
eurjchem-2534	589	2	68	68	NUM
eurjchem-2534	589	3	]	]	PUNCT
eurjchem-2534	589	4	.	.	PUNCT
eurjchem-2534	589	5	kitzen	kitzen	PROPN
eurjchem-2534	589	6	,	,	PUNCT
eurjchem-2534	589	7	j.	j.	PROPN
eurjchem-2534	589	8	j.	j.	PROPN
eurjchem-2534	589	9	e.	e.	PROPN
eurjchem-2534	589	10	m.	m.	PROPN
eurjchem-2534	589	11	;	;	PUNCT
eurjchem-2534	589	12	de	de	PROPN
eurjchem-2534	589	13	jonge	jonge	PROPN
eurjchem-2534	589	14	,	,	PUNCT
eurjchem-2534	589	15	m.	m.	PROPN
eurjchem-2534	589	16	j.	j.	PROPN
eurjchem-2534	589	17	a.	a.	PROPN
eurjchem-2534	589	18	;	;	PUNCT
eurjchem-2534	589	19	lamers	lamer	NOUN
eurjchem-2534	589	20	,	,	PUNCT
eurjchem-2534	589	21	c.	c.	PROPN
eurjchem-2534	589	22	h.	h.	PROPN
eurjchem-2534	589	23	j.	j.	PROPN
eurjchem-2534	589	24	;	;	PUNCT
eurjchem-2534	589	25	eskens	eskens	PROPN
eurjchem-2534	589	26	,	,	PUNCT
eurjchem-2534	589	27	f.	f.	PROPN
eurjchem-2534	589	28	a.	a.	PROPN
eurjchem-2534	589	29	l.	l.	PROPN
eurjchem-2534	589	30	m.	m.	PROPN
eurjchem-2534	589	31	;	;	PUNCT
eurjchem-2534	589	32	van	van	PROPN
eurjchem-2534	589	33	der	der	NOUN
eurjchem-2534	589	34	biessen	biessen	PROPN
eurjchem-2534	589	35	,	,	PUNCT
eurjchem-2534	589	36	d.	d.	PROPN
eurjchem-2534	589	37	;	;	PUNCT
eurjchem-2534	589	38	van	van	PROPN
eurjchem-2534	589	39	doorn	doorn	PROPN
eurjchem-2534	589	40	,	,	PUNCT
eurjchem-2534	589	41	l.	l.	PROPN
eurjchem-2534	589	42	;	;	PUNCT
eurjchem-2534	589	43	ter	ter	NOUN
eurjchem-2534	589	44	steeg	steeg	NOUN
eurjchem-2534	589	45	,	,	PUNCT
eurjchem-2534	589	46	j.	j.	PROPN
eurjchem-2534	589	47	;	;	PUNCT
eurjchem-2534	589	48	brandely	brandely	ADV
eurjchem-2534	589	49	,	,	PUNCT
eurjchem-2534	589	50	m.	m.	NOUN
eurjchem-2534	589	51	;	;	PUNCT
eurjchem-2534	589	52	puozzo	puozzo	PROPN
eurjchem-2534	589	53	,	,	PUNCT
eurjchem-2534	589	54	c.	c.	PROPN
eurjchem-2534	589	55	;	;	PUNCT
eurjchem-2534	589	56	verweij	verweij	PROPN
eurjchem-2534	589	57	,	,	PUNCT
eurjchem-2534	589	58	j.	j.	PROPN
eurjchem-2534	589	59	phase	phase	PROPN
eurjchem-2534	589	60	i	i	PRON
eurjchem-2534	589	61	dose	dose	NOUN
eurjchem-2534	589	62	-	-	PUNCT
eurjchem-2534	589	63	escalation	escalation	NOUN
eurjchem-2534	589	64	study	study	NOUN
eurjchem-2534	589	65	of	of	ADP
eurjchem-2534	589	66	f60008	f60008	PROPN
eurjchem-2534	589	67	,	,	PUNCT
eurjchem-2534	589	68	a	a	DET
eurjchem-2534	589	69	novel	novel	ADJ
eurjchem-2534	589	70	apoptosis	apoptosis	NOUN
eurjchem-2534	589	71	inducer	inducer	NOUN
eurjchem-2534	589	72	,	,	PUNCT
eurjchem-2534	589	73	in	in	ADP
eurjchem-2534	589	74	patients	patient	NOUN
eurjchem-2534	589	75	with	with	ADP
eurjchem-2534	589	76	advanced	advanced	ADJ
eurjchem-2534	589	77	solid	solid	ADJ
eurjchem-2534	589	78	tumours	tumour	NOUN
eurjchem-2534	589	79	.	.	PUNCT
eurjchem-2534	590	1	eur	eur	PROPN
eurjchem-2534	590	2	.	.	PUNCT
eurjchem-2534	591	1	j.	j.	PROPN
eurjchem-2534	591	2	cancer	cancer	PROPN
eurjchem-2534	591	3	2009	2009	NUM
eurjchem-2534	591	4	,	,	PUNCT
eurjchem-2534	591	5	45	45	NUM
eurjchem-2534	591	6	,	,	PUNCT
eurjchem-2534	591	7	1764–1772	1764–1772	NUM
eurjchem-2534	591	8	.	.	PUNCT
eurjchem-2534	592	1	[	[	X
eurjchem-2534	592	2	69	69	NUM
eurjchem-2534	592	3	]	]	PUNCT
eurjchem-2534	592	4	.	.	PUNCT
eurjchem-2534	593	1	ge	ge	PROPN
eurjchem-2534	593	2	,	,	PUNCT
eurjchem-2534	593	3	y.	y.	PROPN
eurjchem-2534	593	4	;	;	PUNCT
eurjchem-2534	593	5	xie	xie	PROPN
eurjchem-2534	593	6	,	,	PUNCT
eurjchem-2534	593	7	h.	h.	PROPN
eurjchem-2534	593	8	;	;	PUNCT
eurjchem-2534	593	9	li	li	PROPN
eurjchem-2534	593	10	,	,	PUNCT
eurjchem-2534	593	11	s.	s.	PROPN
eurjchem-2534	593	12	;	;	PUNCT
eurjchem-2534	593	13	jin	jin	PROPN
eurjchem-2534	593	14	,	,	PUNCT
eurjchem-2534	593	15	b.	b.	PROPN
eurjchem-2534	593	16	;	;	PUNCT
eurjchem-2534	593	17	hou	hou	PROPN
eurjchem-2534	593	18	,	,	PUNCT
eurjchem-2534	593	19	j.	j.	PROPN
eurjchem-2534	593	20	;	;	PUNCT
eurjchem-2534	593	21	zhang	zhang	PROPN
eurjchem-2534	593	22	,	,	PUNCT
eurjchem-2534	593	23	h.	h.	PROPN
eurjchem-2534	593	24	;	;	PUNCT
eurjchem-2534	593	25	shi	shi	PROPN
eurjchem-2534	593	26	,	,	PUNCT
eurjchem-2534	593	27	m.	m.	NOUN
eurjchem-2534	593	28	;	;	PUNCT
eurjchem-2534	593	29	liu	liu	PROPN
eurjchem-2534	593	30	,	,	PUNCT
eurjchem-2534	593	31	z.	z.	PROPN
eurjchem-2534	593	32	treatment	treatment	NOUN
eurjchem-2534	593	33	of	of	ADP
eurjchem-2534	593	34	diabetic	diabetic	ADJ
eurjchem-2534	593	35	nephropathy	nephropathy	NOUN
eurjchem-2534	593	36	with	with	ADP
eurjchem-2534	593	37	tripterygium	tripterygium	NOUN
eurjchem-2534	593	38	wilfordii	wilfordii	ADJ
eurjchem-2534	593	39	hook	hook	NOUN
eurjchem-2534	593	40	f	f	PROPN
eurjchem-2534	593	41	extract	extract	VERB
eurjchem-2534	593	42	:	:	PUNCT
eurjchem-2534	593	43	a	a	DET
eurjchem-2534	593	44	prospective	prospective	ADJ
eurjchem-2534	593	45	,	,	PUNCT
eurjchem-2534	593	46	randomized	randomize	VERB
eurjchem-2534	593	47	,	,	PUNCT
eurjchem-2534	593	48	controlled	control	VERB
eurjchem-2534	593	49	clinical	clinical	ADJ
eurjchem-2534	593	50	trial	trial	NOUN
eurjchem-2534	593	51	.	.	PUNCT
eurjchem-2534	594	1	j.	j.	PROPN
eurjchem-2534	594	2	transl	transl	PROPN
eurjchem-2534	594	3	.	.	PUNCT
eurjchem-2534	595	1	med	med	PROPN
eurjchem-2534	595	2	.	.	PROPN
eurjchem-2534	596	1	2013	2013	NUM
eurjchem-2534	596	2	,	,	PUNCT
eurjchem-2534	596	3	11	11	NUM
eurjchem-2534	596	4	,	,	PUNCT
eurjchem-2534	596	5	134	134	NUM
eurjchem-2534	596	6	.	.	PUNCT
eurjchem-2534	597	1	[	[	X
eurjchem-2534	597	2	70	70	NUM
eurjchem-2534	597	3	]	]	PUNCT
eurjchem-2534	597	4	.	.	PUNCT
eurjchem-2534	598	1	zhu	zhu	PROPN
eurjchem-2534	598	2	,	,	PUNCT
eurjchem-2534	598	3	w.	w.	PROPN
eurjchem-2534	598	4	;	;	PUNCT
eurjchem-2534	598	5	li	li	PROPN
eurjchem-2534	598	6	,	,	PUNCT
eurjchem-2534	598	7	y.	y.	PROPN
eurjchem-2534	598	8	;	;	PUNCT
eurjchem-2534	598	9	gong	gong	PROPN
eurjchem-2534	598	10	,	,	PUNCT
eurjchem-2534	598	11	j.	j.	PROPN
eurjchem-2534	598	12	;	;	PUNCT
eurjchem-2534	598	13	zuo	zuo	PROPN
eurjchem-2534	598	14	,	,	PUNCT
eurjchem-2534	598	15	l.	l.	PROPN
eurjchem-2534	598	16	;	;	PUNCT
eurjchem-2534	598	17	zhang	zhang	PROPN
eurjchem-2534	598	18	,	,	PUNCT
eurjchem-2534	598	19	w.	w.	PROPN
eurjchem-2534	598	20	;	;	PUNCT
eurjchem-2534	598	21	cao	cao	PROPN
eurjchem-2534	598	22	,	,	PUNCT
eurjchem-2534	598	23	l.	l.	PROPN
eurjchem-2534	598	24	;	;	PUNCT
eurjchem-2534	598	25	gu	gu	PROPN
eurjchem-2534	598	26	,	,	PUNCT
eurjchem-2534	598	27	l.	l.	PROPN
eurjchem-2534	598	28	;	;	PUNCT
eurjchem-2534	598	29	guo	guo	PROPN
eurjchem-2534	598	30	,	,	PUNCT
eurjchem-2534	598	31	z.	z.	PROPN
eurjchem-2534	598	32	;	;	PUNCT
eurjchem-2534	598	33	li	li	PROPN
eurjchem-2534	598	34	,	,	PUNCT
eurjchem-2534	598	35	n.	n.	PROPN
eurjchem-2534	598	36	;	;	PUNCT
eurjchem-2534	598	37	li	li	PROPN
eurjchem-2534	598	38	,	,	PUNCT
eurjchem-2534	598	39	j.	j.	PROPN
eurjchem-2534	598	40	tripterygium	tripterygium	PROPN
eurjchem-2534	598	41	wilfordii	wilfordii	ADJ
eurjchem-2534	598	42	hook	hook	NOUN
eurjchem-2534	598	43	.	.	PUNCT
eurjchem-2534	599	1	f.	f.	PROPN
eurjchem-2534	599	2	versus	versus	ADP
eurjchem-2534	599	3	azathioprine	azathioprine	PROPN
eurjchem-2534	599	4	for	for	ADP
eurjchem-2534	599	5	prevention	prevention	NOUN
eurjchem-2534	599	6	of	of	ADP
eurjchem-2534	599	7	postoperative	postoperative	ADJ
eurjchem-2534	599	8	recurrence	recurrence	NOUN
eurjchem-2534	599	9	in	in	ADP
eurjchem-2534	599	10	patients	patient	NOUN
eurjchem-2534	599	11	with	with	ADP
eurjchem-2534	599	12	crohn	crohn	PROPN
eurjchem-2534	599	13	’s	’s	PART
eurjchem-2534	599	14	disease	disease	NOUN
eurjchem-2534	599	15	:	:	PUNCT
eurjchem-2534	599	16	a	a	DET
eurjchem-2534	599	17	randomized	randomized	ADJ
eurjchem-2534	599	18	clinical	clinical	ADJ
eurjchem-2534	599	19	trial	trial	NOUN
eurjchem-2534	599	20	.	.	PUNCT
eurjchem-2534	600	1	dig	dig	NOUN
eurjchem-2534	600	2	.	.	PUNCT
eurjchem-2534	601	1	liver	liver	PROPN
eurjchem-2534	601	2	dis	dis	PROPN
eurjchem-2534	601	3	.	.	PROPN
eurjchem-2534	602	1	2015	2015	NUM
eurjchem-2534	602	2	,	,	PUNCT
eurjchem-2534	602	3	47	47	NUM
eurjchem-2534	602	4	,	,	PUNCT
eurjchem-2534	602	5	14–19	14–19	NUM
eurjchem-2534	602	6	.	.	PUNCT
eurjchem-2534	603	1	[	[	X
eurjchem-2534	603	2	71	71	NUM
eurjchem-2534	603	3	]	]	PUNCT
eurjchem-2534	603	4	.	.	PUNCT
eurjchem-2534	604	1	goldbach	goldbach	NOUN
eurjchem-2534	604	2	-	-	PUNCT
eurjchem-2534	604	3	mansky	mansky	NOUN
eurjchem-2534	604	4	,	,	PUNCT
eurjchem-2534	604	5	r.	r.	PROPN
eurjchem-2534	604	6	comparison	comparison	NOUN
eurjchem-2534	604	7	of	of	ADP
eurjchem-2534	604	8	tripterygium	tripterygium	NOUN
eurjchem-2534	604	9	wilfordii	wilfordii	NOUN
eurjchem-2534	604	10	hook	hook	NOUN
eurjchem-2534	604	11	f	f	PROPN
eurjchem-2534	604	12	versus	versus	ADP
eurjchem-2534	604	13	sulfasalazine	sulfasalazine	NOUN
eurjchem-2534	604	14	in	in	ADP
eurjchem-2534	604	15	the	the	DET
eurjchem-2534	604	16	treatment	treatment	NOUN
eurjchem-2534	604	17	of	of	ADP
eurjchem-2534	604	18	rheumatoid	rheumatoid	NOUN
eurjchem-2534	604	19	arthritis	arthritis	NOUN
eurjchem-2534	604	20	:	:	PUNCT
eurjchem-2534	604	21	a	a	DET
eurjchem-2534	604	22	randomized	randomized	ADJ
eurjchem-2534	604	23	trial	trial	NOUN
eurjchem-2534	604	24	.	.	PUNCT
eurjchem-2534	605	1	ann	ann	PROPN
eurjchem-2534	605	2	.	.	PUNCT
eurjchem-2534	605	3	intern	intern	PROPN
eurjchem-2534	605	4	.	.	PUNCT
eurjchem-2534	606	1	med	med	PROPN
eurjchem-2534	606	2	.	.	PROPN
eurjchem-2534	606	3	2009	2009	NUM
eurjchem-2534	606	4	,	,	PUNCT
eurjchem-2534	606	5	151	151	NUM
eurjchem-2534	606	6	,	,	PUNCT
eurjchem-2534	606	7	229–240	229–240	NUM
eurjchem-2534	606	8	.	.	PUNCT
eurjchem-2534	607	1	[	[	X
eurjchem-2534	607	2	72	72	NUM
eurjchem-2534	607	3	]	]	PUNCT
eurjchem-2534	607	4	.	.	PUNCT
eurjchem-2534	608	1	liu	liu	PROPN
eurjchem-2534	608	2	,	,	PUNCT
eurjchem-2534	608	3	y.	y.	PROPN
eurjchem-2534	608	4	;	;	PUNCT
eurjchem-2534	608	5	tu	tu	PROPN
eurjchem-2534	608	6	,	,	PUNCT
eurjchem-2534	608	7	s.	s.	PROPN
eurjchem-2534	608	8	;	;	PUNCT
eurjchem-2534	608	9	gao	gao	PROPN
eurjchem-2534	608	10	,	,	PUNCT
eurjchem-2534	608	11	w.	w.	PROPN
eurjchem-2534	608	12	;	;	PUNCT
eurjchem-2534	608	13	wang	wang	PROPN
eurjchem-2534	608	14	,	,	PUNCT
eurjchem-2534	608	15	y.	y.	PROPN
eurjchem-2534	608	16	;	;	PUNCT
eurjchem-2534	608	17	liu	liu	PROPN
eurjchem-2534	608	18	,	,	PUNCT
eurjchem-2534	608	19	p.	p.	PROPN
eurjchem-2534	608	20	;	;	PUNCT
eurjchem-2534	608	21	hu	hu	PROPN
eurjchem-2534	608	22	,	,	PUNCT
eurjchem-2534	608	23	y.	y.	PROPN
eurjchem-2534	608	24	;	;	PUNCT
eurjchem-2534	608	25	dong	dong	PROPN
eurjchem-2534	608	26	,	,	PUNCT
eurjchem-2534	608	27	h.	h.	NOUN
eurjchem-2534	608	28	extracts	extract	NOUN
eurjchem-2534	608	29	of	of	ADP
eurjchem-2534	608	30	tripterygium	tripterygium	NOUN
eurjchem-2534	608	31	wilfordii	wilfordii	NOUN
eurjchem-2534	608	32	hook	hook	NOUN
eurjchem-2534	608	33	f	f	NOUN
eurjchem-2534	608	34	in	in	ADP
eurjchem-2534	608	35	the	the	DET
eurjchem-2534	608	36	treatment	treatment	NOUN
eurjchem-2534	608	37	of	of	ADP
eurjchem-2534	608	38	rheumatoid	rheumatoid	NOUN
eurjchem-2534	608	39	arthritis	arthritis	NOUN
eurjchem-2534	608	40	:	:	PUNCT
eurjchem-2534	608	41	a	a	DET
eurjchem-2534	608	42	systemic	systemic	ADJ
eurjchem-2534	608	43	review	review	NOUN
eurjchem-2534	608	44	and	and	CCONJ
eurjchem-2534	608	45	meta	meta	NOUN
eurjchem-2534	608	46	-	-	PUNCT
eurjchem-2534	608	47	analysis	analysis	NOUN
eurjchem-2534	608	48	of	of	ADP
eurjchem-2534	608	49	randomised	randomised	ADJ
eurjchem-2534	608	50	controlled	control	VERB
eurjchem-2534	608	51	trials	trial	NOUN
eurjchem-2534	608	52	.	.	PUNCT
eurjchem-2534	609	1	evid	evid	PROPN
eurjchem-2534	609	2	.	.	PUNCT
eurjchem-2534	610	1	based	base	VERB
eurjchem-2534	610	2	.	.	PUNCT
eurjchem-2534	611	1	complement	complement	NOUN
eurjchem-2534	611	2	.	.	PUNCT
eurjchem-2534	612	1	alternat	alternat	NOUN
eurjchem-2534	612	2	.	.	PUNCT
eurjchem-2534	613	1	med	med	PROPN
eurjchem-2534	613	2	.	.	PROPN
eurjchem-2534	614	1	2013	2013	NUM
eurjchem-2534	614	2	,	,	PUNCT
eurjchem-2534	614	3	2013	2013	NUM
eurjchem-2534	614	4	,	,	PUNCT
eurjchem-2534	614	5	1–11	1–11	PROPN
eurjchem-2534	614	6	,	,	PUNCT
eurjchem-2534	614	7	410793	410793	NUM
eurjchem-2534	614	8	.	.	PUNCT
eurjchem-2534	615	1	copyright	copyright	NOUN
eurjchem-2534	615	2	©	©	ADP
eurjchem-2534	615	3	2024	2024	NUM
eurjchem-2534	615	4	by	by	ADP
eurjchem-2534	615	5	authors	author	NOUN
eurjchem-2534	615	6	.	.	PUNCT
eurjchem-2534	616	1	this	this	DET
eurjchem-2534	616	2	work	work	NOUN
eurjchem-2534	616	3	is	be	AUX
eurjchem-2534	616	4	published	publish	VERB
eurjchem-2534	616	5	and	and	CCONJ
eurjchem-2534	616	6	licensed	license	VERB
eurjchem-2534	616	7	by	by	ADP
eurjchem-2534	616	8	atlanta	atlanta	PROPN
eurjchem-2534	616	9	publishing	publishing	PROPN
eurjchem-2534	616	10	house	house	PROPN
eurjchem-2534	616	11	llc	llc	PROPN
eurjchem-2534	616	12	,	,	PUNCT
eurjchem-2534	616	13	atlanta	atlanta	PROPN
eurjchem-2534	616	14	,	,	PUNCT
eurjchem-2534	616	15	ga	ga	PROPN
eurjchem-2534	616	16	,	,	PUNCT
eurjchem-2534	616	17	usa	usa	PROPN
eurjchem-2534	616	18	.	.	PUNCT
eurjchem-2534	617	1	the	the	DET
eurjchem-2534	617	2	full	full	ADJ
eurjchem-2534	617	3	terms	term	NOUN
eurjchem-2534	617	4	of	of	ADP
eurjchem-2534	617	5	this	this	DET
eurjchem-2534	617	6	license	license	NOUN
eurjchem-2534	617	7	are	be	AUX
eurjchem-2534	617	8	available	available	ADJ
eurjchem-2534	617	9	at	at	ADP
eurjchem-2534	617	10	https://www.eurjchem.com/index.php/eurjchem/terms	https://www.eurjchem.com/index.php/eurjchem/term	NOUN
eurjchem-2534	617	11	and	and	CCONJ
eurjchem-2534	617	12	incorporate	incorporate	VERB
eurjchem-2534	617	13	the	the	DET
eurjchem-2534	617	14	creative	creative	ADJ
eurjchem-2534	617	15	commons	common	NOUN
eurjchem-2534	617	16	attribution	attribution	NOUN
eurjchem-2534	617	17	-	-	PUNCT
eurjchem-2534	617	18	non	non	ADJ
eurjchem-2534	617	19	commercial	commercial	NOUN
eurjchem-2534	617	20	(	(	PUNCT
eurjchem-2534	617	21	cc	cc	NOUN
eurjchem-2534	617	22	by	by	ADP
eurjchem-2534	617	23	nc	nc	PROPN
eurjchem-2534	617	24	)	)	PUNCT
eurjchem-2534	617	25	(	(	PUNCT
eurjchem-2534	617	26	international	international	ADJ
eurjchem-2534	617	27	,	,	PUNCT
eurjchem-2534	617	28	v4.0	v4.0	NOUN
eurjchem-2534	617	29	)	)	PUNCT
eurjchem-2534	617	30	license	license	NOUN
eurjchem-2534	617	31	(	(	PUNCT
eurjchem-2534	617	32	http://creativecommons.org/licenses/by-nc/4.0	http://creativecommons.org/licenses/by-nc/4.0	NOUN
eurjchem-2534	617	33	)	)	PUNCT
eurjchem-2534	617	34	.	.	PUNCT
eurjchem-2534	618	1	by	by	ADP
eurjchem-2534	618	2	accessing	access	VERB
eurjchem-2534	618	3	the	the	DET
eurjchem-2534	618	4	work	work	NOUN
eurjchem-2534	618	5	,	,	PUNCT
eurjchem-2534	618	6	you	you	PRON
eurjchem-2534	618	7	hereby	hereby	ADV
eurjchem-2534	618	8	accept	accept	VERB
eurjchem-2534	618	9	the	the	DET
eurjchem-2534	618	10	terms	term	NOUN
eurjchem-2534	618	11	.	.	PUNCT
eurjchem-2534	619	1	this	this	PRON
eurjchem-2534	619	2	is	be	AUX
eurjchem-2534	619	3	an	an	DET
eurjchem-2534	619	4	open	open	ADJ
eurjchem-2534	619	5	access	access	NOUN
eurjchem-2534	619	6	article	article	NOUN
eurjchem-2534	619	7	distributed	distribute	VERB
eurjchem-2534	619	8	under	under	ADP
eurjchem-2534	619	9	the	the	DET
eurjchem-2534	619	10	terms	term	NOUN
eurjchem-2534	619	11	and	and	CCONJ
eurjchem-2534	619	12	conditions	condition	NOUN
eurjchem-2534	619	13	of	of	ADP
eurjchem-2534	619	14	the	the	DET
eurjchem-2534	619	15	cc	cc	PROPN
eurjchem-2534	619	16	by	by	ADP
eurjchem-2534	619	17	nc	nc	PROPN
eurjchem-2534	619	18	license	license	PROPN
eurjchem-2534	619	19	,	,	PUNCT
eurjchem-2534	619	20	which	which	PRON
eurjchem-2534	619	21	permits	permit	VERB
eurjchem-2534	619	22	unrestricted	unrestricted	ADJ
eurjchem-2534	619	23	non	non	ADJ
eurjchem-2534	619	24	-	-	ADJ
eurjchem-2534	619	25	commercial	commercial	ADJ
eurjchem-2534	619	26	use	use	NOUN
eurjchem-2534	619	27	,	,	PUNCT
eurjchem-2534	619	28	distribution	distribution	NOUN
eurjchem-2534	619	29	,	,	PUNCT
eurjchem-2534	619	30	and	and	CCONJ
eurjchem-2534	619	31	reproduction	reproduction	NOUN
eurjchem-2534	619	32	in	in	ADP
eurjchem-2534	619	33	any	any	DET
eurjchem-2534	619	34	medium	medium	NOUN
eurjchem-2534	619	35	,	,	PUNCT
eurjchem-2534	619	36	provided	provide	VERB
eurjchem-2534	619	37	the	the	DET
eurjchem-2534	619	38	original	original	ADJ
eurjchem-2534	619	39	work	work	NOUN
eurjchem-2534	619	40	is	be	AUX
eurjchem-2534	619	41	properly	properly	ADV
eurjchem-2534	619	42	cited	cite	VERB
eurjchem-2534	619	43	without	without	ADP
eurjchem-2534	619	44	any	any	DET
eurjchem-2534	619	45	further	further	ADJ
eurjchem-2534	619	46	permission	permission	NOUN
eurjchem-2534	619	47	from	from	ADP
eurjchem-2534	619	48	atlanta	atlanta	PROPN
eurjchem-2534	619	49	publishing	publishing	PROPN
eurjchem-2534	619	50	house	house	PROPN
eurjchem-2534	619	51	llc	llc	PROPN
eurjchem-2534	619	52	(	(	PUNCT
eurjchem-2534	619	53	european	european	PROPN
eurjchem-2534	619	54	journal	journal	PROPN
eurjchem-2534	619	55	of	of	ADP
eurjchem-2534	619	56	chemistry	chemistry	NOUN
eurjchem-2534	619	57	)	)	PUNCT
eurjchem-2534	619	58	.	.	PUNCT
eurjchem-2534	620	1	no	no	DET
eurjchem-2534	620	2	use	use	NOUN
eurjchem-2534	620	3	,	,	PUNCT
eurjchem-2534	620	4	distribution	distribution	NOUN
eurjchem-2534	620	5	,	,	PUNCT
eurjchem-2534	620	6	or	or	CCONJ
eurjchem-2534	620	7	reproduction	reproduction	NOUN
eurjchem-2534	620	8	is	be	AUX
eurjchem-2534	620	9	permitted	permit	VERB
eurjchem-2534	620	10	which	which	PRON
eurjchem-2534	620	11	does	do	AUX
eurjchem-2534	620	12	not	not	PART
eurjchem-2534	620	13	comply	comply	VERB
eurjchem-2534	620	14	with	with	ADP
eurjchem-2534	620	15	these	these	DET
eurjchem-2534	620	16	terms	term	NOUN
eurjchem-2534	620	17	.	.	PUNCT
eurjchem-2534	621	1	permissions	permission	NOUN
eurjchem-2534	621	2	for	for	ADP
eurjchem-2534	621	3	commercial	commercial	ADJ
eurjchem-2534	621	4	use	use	NOUN
eurjchem-2534	621	5	of	of	ADP
eurjchem-2534	621	6	this	this	DET
eurjchem-2534	621	7	work	work	NOUN
eurjchem-2534	621	8	beyond	beyond	ADP
eurjchem-2534	621	9	the	the	DET
eurjchem-2534	621	10	scope	scope	NOUN
eurjchem-2534	621	11	of	of	ADP
eurjchem-2534	621	12	the	the	DET
eurjchem-2534	621	13	license	license	NOUN
eurjchem-2534	621	14	(	(	PUNCT
eurjchem-2534	621	15	https://www.eurjchem.com/index.php/eurjchem/terms	https://www.eurjchem.com/index.php/eurjchem/term	NOUN
eurjchem-2534	621	16	)	)	PUNCT
eurjchem-2534	621	17	are	be	AUX
eurjchem-2534	621	18	administered	administer	VERB
eurjchem-2534	621	19	by	by	ADP
eurjchem-2534	621	20	atlanta	atlanta	PROPN
eurjchem-2534	621	21	publishing	publishing	PROPN
eurjchem-2534	621	22	house	house	PROPN
eurjchem-2534	621	23	llc	llc	PROPN
eurjchem-2534	621	24	(	(	PUNCT
eurjchem-2534	621	25	european	european	PROPN
eurjchem-2534	621	26	journal	journal	PROPN
eurjchem-2534	621	27	of	of	ADP
eurjchem-2534	621	28	chemistry	chemistry	NOUN
eurjchem-2534	621	29	)	)	PUNCT
eurjchem-2534	621	30	.	.	PUNCT
eurjchem-2534	622	1	https://clinicaltrials.gov/study/%20nct05413226	https://clinicaltrials.gov/study/%20nct05413226	PUNCT
eurjchem-2534	623	1	https://clinicaltrials.gov/study/%20nct05413226	https://clinicaltrials.gov/study/%20nct05413226	PUNCT
eurjchem-2534	624	1	https://clinicaltrials.gov/study/nct05494112	https://clinicaltrials.gov/study/nct05494112	PROPN
eurjchem-2534	624	2	https://www.eurjchem.com/index.php/eurjchem/terms	https://www.eurjchem.com/index.php/eurjchem/term	VERB
eurjchem-2534	624	3	http://creativecommons.org/licenses/by-nc/4.0	http://creativecommons.org/licenses/by-nc/4.0	PROPN
eurjchem-2534	624	4	https://www.eurjchem.com/index.php/eurjchem/terms	https://www.eurjchem.com/index.php/eurjchem/term	NOUN
eurjchem-2534	624	5	1	1	NUM
eurjchem-2534	624	6	.	.	PUNCT
eurjchem-2534	624	7	introduction	introduction	NOUN
eurjchem-2534	624	8	2	2	NUM
eurjchem-2534	624	9	.	.	PUNCT
eurjchem-2534	624	10	background	background	NOUN
eurjchem-2534	624	11	2.1	2.1	NUM
eurjchem-2534	624	12	.	.	PUNCT
eurjchem-2534	625	1	medicinal	medicinal	ADJ
eurjchem-2534	625	2	chemistry	chemistry	NOUN
eurjchem-2534	625	3	of	of	ADP
eurjchem-2534	625	4	celastrol	celastrol	NOUN
eurjchem-2534	625	5	2.2	2.2	NUM
eurjchem-2534	625	6	.	.	PUNCT
eurjchem-2534	626	1	triazole	triazole	ADJ
eurjchem-2534	626	2	derivatives	derivative	NOUN
eurjchem-2534	626	3	and	and	CCONJ
eurjchem-2534	626	4	click	click	VERB
eurjchem-2534	626	5	chemistry	chemistry	NOUN
eurjchem-2534	626	6	of	of	ADP
eurjchem-2534	626	7	celastrol	celastrol	NOUN
eurjchem-2534	626	8	3	3	NUM
eurjchem-2534	626	9	.	.	PUNCT
eurjchem-2534	626	10	drug	drug	NOUN
eurjchem-2534	626	11	delivery	delivery	NOUN
eurjchem-2534	626	12	of	of	ADP
eurjchem-2534	626	13	celastrol	celastrol	NOUN
eurjchem-2534	626	14	3.1	3.1	NUM
eurjchem-2534	626	15	.	.	PUNCT
eurjchem-2534	627	1	direct	direct	ADJ
eurjchem-2534	627	2	modification	modification	NOUN
eurjchem-2534	627	3	3.2	3.2	NUM
eurjchem-2534	627	4	.	.	PUNCT
eurjchem-2534	628	1	indirect	indirect	ADJ
eurjchem-2534	628	2	modification	modification	NOUN
eurjchem-2534	628	3	4	4	NUM
eurjchem-2534	628	4	.	.	PUNCT
eurjchem-2534	628	5	future	future	ADJ
eurjchem-2534	628	6	directions	direction	NOUN
eurjchem-2534	628	7	and	and	CCONJ
eurjchem-2534	628	8	clinical	clinical	ADJ
eurjchem-2534	628	9	trials	trial	NOUN
eurjchem-2534	628	10	4.1	4.1	NUM
eurjchem-2534	628	11	.	.	PUNCT
eurjchem-2534	628	12	completed	complete	VERB
eurjchem-2534	628	13	and	and	CCONJ
eurjchem-2534	628	14	ongoing	ongoing	ADJ
eurjchem-2534	628	15	clinical	clinical	ADJ
eurjchem-2534	628	16	trials	trial	NOUN
eurjchem-2534	628	17	5	5	NUM
eurjchem-2534	628	18	.	.	PUNCT
eurjchem-2534	629	1	conclusions	conclusion	NOUN
eurjchem-2534	629	2	acknowledgements	acknowledgement	VERB
eurjchem-2534	629	3	abbreviations	abbreviation	NOUN
eurjchem-2534	629	4	disclosure	disclosure	NOUN
eurjchem-2534	629	5	statement	statement	NOUN
eurjchem-2534	629	6	credit	credit	NOUN
eurjchem-2534	629	7	authorship	authorship	NOUN
eurjchem-2534	629	8	contribution	contribution	NOUN
eurjchem-2534	629	9	statement	statement	NOUN
eurjchem-2534	629	10	funding	fund	VERB
eurjchem-2534	629	11	orcid	orcid	NOUN
eurjchem-2534	629	12	and	and	CCONJ
eurjchem-2534	629	13	email	email	NOUN
eurjchem-2534	629	14	references	reference	NOUN
eurjchem-2534	629	15	printfield10	printfield10	PROPN
eurjchem-2534	629	16	:	:	PUNCT
eurjchem-2534	629	17	printfield11	printfield11	NOUN
eurjchem-2534	629	18	:	:	PUNCT
eurjchem-2534	629	19	printfield12	printfield12	PROPN
eurjchem-2534	629	20	:	:	PUNCT
eurjchem-2534	629	21	printfield13	printfield13	VERB
eurjchem-2534	629	22	:	:	PUNCT
eurjchem-2534	629	23	printfield14	printfield14	NOUN
eurjchem-2534	629	24	:	:	PUNCT
eurjchem-2534	629	25	printfield15	printfield15	NOUN
eurjchem-2534	629	26	:	:	PUNCT
eurjchem-2534	629	27	printfield16	printfield16	ADJ
eurjchem-2534	629	28	:	:	PUNCT
eurjchem-2534	629	29	printfield17	printfield17	NOUN
eurjchem-2534	629	30	:	:	PUNCT
eurjchem-2534	629	31	printfield18	printfield18	NOUN
eurjchem-2534	629	32	:	:	PUNCT
eurjchem-2534	629	33	printfield19	printfield19	NOUN
eurjchem-2534	629	34	:	:	PUNCT
eurjchem-2534	629	35	printfield110	printfield110	PROPN
eurjchem-2534	629	36	:	:	PUNCT
eurjchem-2534	629	37	printfield20	printfield20	PROPN
eurjchem-2534	629	38	:	:	PUNCT
eurjchem-2534	629	39	printfield21	printfield21	ADJ
eurjchem-2534	629	40	:	:	PUNCT
eurjchem-2534	629	41	printfield22	printfield22	NOUN
eurjchem-2534	629	42	:	:	PUNCT
eurjchem-2534	629	43	printfield23	printfield23	NOUN
eurjchem-2534	629	44	:	:	PUNCT
eurjchem-2534	629	45	printfield24	printfield24	NOUN
eurjchem-2534	629	46	:	:	PUNCT
eurjchem-2534	629	47	printfield25	printfield25	NOUN
eurjchem-2534	629	48	:	:	PUNCT
eurjchem-2534	629	49	printfield26	printfield26	ADJ
eurjchem-2534	629	50	:	:	PUNCT
eurjchem-2534	629	51	printfield27	printfield27	NOUN
eurjchem-2534	629	52	:	:	PUNCT
eurjchem-2534	629	53	printfield28	printfield28	NOUN
eurjchem-2534	629	54	:	:	PUNCT
eurjchem-2534	629	55	printfield29	printfield29	ADV
eurjchem-2534	629	56	:	:	PUNCT
eurjchem-2534	629	57	printfield210	printfield210	PROPN
eurjchem-2534	629	58	:	:	PUNCT