id	sid	tid	token	lemma	pos
eurjchem-2615	1	1	click	click	VERB
eurjchem-2615	1	2	chemistry	chemistry	NOUN
eurjchem-2615	1	3	in	in	ADP
eurjchem-2615	1	4	tuberculosis	tuberculosis	NOUN
eurjchem-2615	1	5	research	research	NOUN
eurjchem-2615	1	6	:	:	PUNCT
eurjchem-2615	1	7	from	from	ADP
eurjchem-2615	1	8	drug	drug	NOUN
eurjchem-2615	1	9	design	design	NOUN
eurjchem-2615	1	10	to	to	ADP
eurjchem-2615	1	11	therapeutic	therapeutic	ADJ
eurjchem-2615	1	12	delivery	delivery	NOUN
eurjchem-2615	1	13	a	a	DET
eurjchem-2615	1	14	systematic	systematic	ADJ
eurjchem-2615	1	15	review	review	NOUN
eurjchem-2615	1	16	european	european	PROPN
eurjchem-2615	1	17	journal	journal	PROPN
eurjchem-2615	1	18	of	of	ADP
eurjchem-2615	1	19	chemistry	chemistry	NOUN
eurjchem-2615	1	20	16	16	NUM
eurjchem-2615	1	21	(	(	PUNCT
eurjchem-2615	1	22	1	1	NUM
eurjchem-2615	1	23	)	)	PUNCT
eurjchem-2615	1	24	(	(	PUNCT
eurjchem-2615	1	25	2025	2025	NUM
eurjchem-2615	1	26	)	)	PUNCT
eurjchem-2615	1	27	83	83	NUM
eurjchem-2615	1	28	-	-	SYM
eurjchem-2615	1	29	96	96	NUM
eurjchem-2615	1	30	european	european	ADJ
eurjchem-2615	1	31	journal	journal	PROPN
eurjchem-2615	1	32	of	of	ADP
eurjchem-2615	1	33	chemistry	chemistry	NOUN
eurjchem-2615	1	34	issn	issn	VERB
eurjchem-2615	1	35	2153	2153	NUM
eurjchem-2615	1	36	-	-	SYM
eurjchem-2615	1	37	2249	2249	NUM
eurjchem-2615	1	38	(	(	PUNCT
eurjchem-2615	1	39	print	print	NOUN
eurjchem-2615	1	40	)	)	PUNCT
eurjchem-2615	1	41	/	/	PUNCT
eurjchem-2615	1	42	issn	issn	PROPN
eurjchem-2615	1	43	2153	2153	NUM
eurjchem-2615	1	44	-	-	SYM
eurjchem-2615	1	45	2257	2257	NUM
eurjchem-2615	1	46	(	(	PUNCT
eurjchem-2615	1	47	online	online	ADJ
eurjchem-2615	1	48	)	)	PUNCT
eurjchem-2615	1	49	–	–	PUNCT
eurjchem-2615	2	1	copyright	copyright	NOUN
eurjchem-2615	2	2	©	©	PROPN
eurjchem-2615	2	3	2025	2025	NUM
eurjchem-2615	2	4	the	the	DET
eurjchem-2615	2	5	authors	author	NOUN
eurjchem-2615	2	6	–	–	PUNCT
eurjchem-2615	2	7	atlanta	atlanta	PROPN
eurjchem-2615	2	8	publishing	publishing	PROPN
eurjchem-2615	2	9	house	house	PROPN
eurjchem-2615	2	10	llc	llc	PROPN
eurjchem-2615	2	11	–	–	PUNCT
eurjchem-2615	2	12	printed	print	VERB
eurjchem-2615	2	13	in	in	ADP
eurjchem-2615	2	14	the	the	DET
eurjchem-2615	2	15	usa	usa	PROPN
eurjchem-2615	2	16	.	.	PUNCT
eurjchem-2615	3	1	this	this	DET
eurjchem-2615	3	2	work	work	NOUN
eurjchem-2615	3	3	is	be	AUX
eurjchem-2615	3	4	published	publish	VERB
eurjchem-2615	3	5	and	and	CCONJ
eurjchem-2615	3	6	licensed	license	VERB
eurjchem-2615	3	7	by	by	ADP
eurjchem-2615	3	8	atlanta	atlanta	PROPN
eurjchem-2615	3	9	publishing	publishing	PROPN
eurjchem-2615	3	10	house	house	PROPN
eurjchem-2615	3	11	llc	llc	PROPN
eurjchem-2615	3	12	–	–	PUNCT
eurjchem-2615	3	13	cc	cc	PROPN
eurjchem-2615	3	14	by	by	ADP
eurjchem-2615	3	15	nc	nc	PROPN
eurjchem-2615	3	16	–	–	PUNCT
eurjchem-2615	3	17	some	some	DET
eurjchem-2615	3	18	rights	right	NOUN
eurjchem-2615	3	19	reserved	reserve	VERB
eurjchem-2615	3	20	.	.	PUNCT
eurjchem-2615	4	1	https://dx.doi.org/10.5155/eurjchem.16.1.83-96.2615	https://dx.doi.org/10.5155/eurjchem.16.1.83-96.2615	PROPN
eurjchem-2615	4	2	european	european	ADJ
eurjchem-2615	4	3	journal	journal	PROPN
eurjchem-2615	4	4	of	of	ADP
eurjchem-2615	4	5	chemistry	chemistry	NOUN
eurjchem-2615	4	6	view	view	NOUN
eurjchem-2615	4	7	journal	journal	PROPN
eurjchem-2615	4	8	online	online	PROPN
eurjchem-2615	4	9	view	view	NOUN
eurjchem-2615	4	10	article	article	NOUN
eurjchem-2615	4	11	online	online	ADV
eurjchem-2615	4	12	click	click	VERB
eurjchem-2615	4	13	chemistry	chemistry	NOUN
eurjchem-2615	4	14	in	in	ADP
eurjchem-2615	4	15	tuberculosis	tuberculosis	NOUN
eurjchem-2615	4	16	research	research	NOUN
eurjchem-2615	4	17	:	:	PUNCT
eurjchem-2615	4	18	from	from	ADP
eurjchem-2615	4	19	drug	drug	NOUN
eurjchem-2615	4	20	design	design	NOUN
eurjchem-2615	4	21	to	to	ADP
eurjchem-2615	4	22	therapeutic	therapeutic	ADJ
eurjchem-2615	4	23	delivery	delivery	NOUN
eurjchem-2615	4	24	a	a	DET
eurjchem-2615	4	25	systematic	systematic	ADJ
eurjchem-2615	4	26	review	review	NOUN
eurjchem-2615	4	27	ren	ren	PROPN
eurjchem-2615	4	28	zimo	zimo	PROPN
eurjchem-2615	4	29	and	and	CCONJ
eurjchem-2615	4	30	paolo	paolo	PROPN
eurjchem-2615	4	31	coghi	coghi	PROPN
eurjchem-2615	4	32	*	*	PUNCT
eurjchem-2615	4	33	department	department	PROPN
eurjchem-2615	4	34	of	of	ADP
eurjchem-2615	4	35	medical	medical	ADJ
eurjchem-2615	4	36	division	division	NOUN
eurjchem-2615	4	37	,	,	PUNCT
eurjchem-2615	4	38	school	school	NOUN
eurjchem-2615	4	39	of	of	ADP
eurjchem-2615	4	40	pharmacy	pharmacy	NOUN
eurjchem-2615	4	41	,	,	PUNCT
eurjchem-2615	4	42	macau	macau	PROPN
eurjchem-2615	4	43	university	university	PROPN
eurjchem-2615	4	44	of	of	ADP
eurjchem-2615	4	45	science	science	NOUN
eurjchem-2615	4	46	and	and	CCONJ
eurjchem-2615	4	47	technology	technology	NOUN
eurjchem-2615	4	48	,	,	PUNCT
eurjchem-2615	4	49	macau	macau	PROPN
eurjchem-2615	4	50	,	,	PUNCT
eurjchem-2615	4	51	999078	999078	NUM
eurjchem-2615	4	52	,	,	PUNCT
eurjchem-2615	4	53	china	china	PROPN
eurjchem-2615	4	54	*	*	PUNCT
eurjchem-2615	4	55	corresponding	correspond	VERB
eurjchem-2615	4	56	author	author	NOUN
eurjchem-2615	4	57	at	at	ADP
eurjchem-2615	4	58	:	:	PUNCT
eurjchem-2615	4	59	department	department	NOUN
eurjchem-2615	4	60	of	of	ADP
eurjchem-2615	4	61	medical	medical	ADJ
eurjchem-2615	4	62	division	division	NOUN
eurjchem-2615	4	63	,	,	PUNCT
eurjchem-2615	4	64	school	school	NOUN
eurjchem-2615	4	65	of	of	ADP
eurjchem-2615	4	66	pharmacy	pharmacy	NOUN
eurjchem-2615	4	67	,	,	PUNCT
eurjchem-2615	4	68	macau	macau	PROPN
eurjchem-2615	4	69	university	university	PROPN
eurjchem-2615	4	70	of	of	ADP
eurjchem-2615	4	71	science	science	NOUN
eurjchem-2615	4	72	and	and	CCONJ
eurjchem-2615	4	73	technology	technology	NOUN
eurjchem-2615	4	74	,	,	PUNCT
eurjchem-2615	4	75	macau	macau	PROPN
eurjchem-2615	4	76	,	,	PUNCT
eurjchem-2615	4	77	999078	999078	NUM
eurjchem-2615	4	78	,	,	PUNCT
eurjchem-2615	4	79	china	china	PROPN
eurjchem-2615	4	80	.	.	PUNCT
eurjchem-2615	5	1	e	e	X
eurjchem-2615	5	2	-	-	NOUN
eurjchem-2615	5	3	mail	mail	NOUN
eurjchem-2615	5	4	:	:	PUNCT
eurjchem-2615	5	5	coghips@must.edu.mo	coghips@must.edu.mo	NOUN
eurjchem-2615	5	6	(	(	PUNCT
eurjchem-2615	5	7	p.	p.	PROPN
eurjchem-2615	5	8	coghi	coghi	PROPN
eurjchem-2615	5	9	)	)	PUNCT
eurjchem-2615	5	10	.	.	PUNCT
eurjchem-2615	6	1	10.5155	10.5155	NUM
eurjchem-2615	6	2	/	/	SYM
eurjchem-2615	6	3	eurjchem.16.1.83	eurjchem.16.1.83	ADJ
eurjchem-2615	6	4	-	-	PUNCT
eurjchem-2615	6	5	96.2615	96.2615	NUM
eurjchem-2615	6	6	received	receive	VERB
eurjchem-2615	6	7	:	:	PUNCT
eurjchem-2615	6	8	4	4	NUM
eurjchem-2615	6	9	november	november	NOUN
eurjchem-2615	6	10	2024	2024	NUM
eurjchem-2615	6	11	received	receive	VERB
eurjchem-2615	6	12	in	in	ADP
eurjchem-2615	6	13	revised	revise	VERB
eurjchem-2615	6	14	form	form	NOUN
eurjchem-2615	6	15	:	:	PUNCT
eurjchem-2615	6	16	7	7	NUM
eurjchem-2615	6	17	january	january	NOUN
eurjchem-2615	6	18	2025	2025	NUM
eurjchem-2615	6	19	accepted	accept	VERB
eurjchem-2615	6	20	:	:	PUNCT
eurjchem-2615	6	21	20	20	NUM
eurjchem-2615	6	22	january	january	NOUN
eurjchem-2615	6	23	2025	2025	NUM
eurjchem-2615	6	24	published	publish	VERB
eurjchem-2615	6	25	online	online	ADV
eurjchem-2615	6	26	:	:	PUNCT
eurjchem-2615	6	27	31	31	NUM
eurjchem-2615	6	28	march	march	NOUN
eurjchem-2615	6	29	2025	2025	NUM
eurjchem-2615	6	30	printed	print	VERB
eurjchem-2615	6	31	:	:	PUNCT
eurjchem-2615	6	32	31	31	NUM
eurjchem-2615	6	33	march	march	NOUN
eurjchem-2615	6	34	2025	2025	NUM
eurjchem-2615	6	35	the	the	DET
eurjchem-2615	6	36	molecular	molecular	ADJ
eurjchem-2615	6	37	hybridization	hybridization	NOUN
eurjchem-2615	6	38	of	of	ADP
eurjchem-2615	6	39	1,2,3	1,2,3	NOUN
eurjchem-2615	6	40	-	-	NOUN
eurjchem-2615	6	41	triazoles	triazole	NOUN
eurjchem-2615	6	42	with	with	ADP
eurjchem-2615	6	43	various	various	ADJ
eurjchem-2615	6	44	bioactive	bioactive	ADJ
eurjchem-2615	6	45	scaffolds	scaffold	NOUN
eurjchem-2615	6	46	has	have	AUX
eurjchem-2615	6	47	become	become	VERB
eurjchem-2615	6	48	a	a	DET
eurjchem-2615	6	49	promising	promising	ADJ
eurjchem-2615	6	50	approach	approach	NOUN
eurjchem-2615	6	51	to	to	ADP
eurjchem-2615	6	52	the	the	DET
eurjchem-2615	6	53	development	development	NOUN
eurjchem-2615	6	54	of	of	ADP
eurjchem-2615	6	55	new	new	ADJ
eurjchem-2615	6	56	antitubercular	antitubercular	ADJ
eurjchem-2615	6	57	drugs	drug	NOUN
eurjchem-2615	6	58	,	,	PUNCT
eurjchem-2615	6	59	offering	offer	VERB
eurjchem-2615	6	60	a	a	DET
eurjchem-2615	6	61	versatile	versatile	ADJ
eurjchem-2615	6	62	platform	platform	NOUN
eurjchem-2615	6	63	for	for	ADP
eurjchem-2615	6	64	improving	improve	VERB
eurjchem-2615	6	65	drug	drug	NOUN
eurjchem-2615	6	66	efficacy	efficacy	NOUN
eurjchem-2615	6	67	and	and	CCONJ
eurjchem-2615	6	68	specificity	specificity	NOUN
eurjchem-2615	6	69	.	.	PUNCT
eurjchem-2615	7	1	this	this	DET
eurjchem-2615	7	2	review	review	NOUN
eurjchem-2615	7	3	covers	cover	VERB
eurjchem-2615	7	4	key	key	ADJ
eurjchem-2615	7	5	advancements	advancement	NOUN
eurjchem-2615	7	6	over	over	ADP
eurjchem-2615	7	7	the	the	DET
eurjchem-2615	7	8	past	past	ADJ
eurjchem-2615	7	9	decade	decade	NOUN
eurjchem-2615	7	10	in	in	ADP
eurjchem-2615	7	11	creating	create	VERB
eurjchem-2615	7	12	triazole	triazole	NOUN
eurjchem-2615	7	13	-	-	PUNCT
eurjchem-2615	7	14	based	base	VERB
eurjchem-2615	7	15	hybrids	hybrid	NOUN
eurjchem-2615	7	16	that	that	PRON
eurjchem-2615	7	17	integrate	integrate	VERB
eurjchem-2615	7	18	azoles	azole	NOUN
eurjchem-2615	7	19	,	,	PUNCT
eurjchem-2615	7	20	coumarin	coumarin	NOUN
eurjchem-2615	7	21	/	/	SYM
eurjchem-2615	7	22	chromene	chromene	ADJ
eurjchem-2615	7	23	,	,	PUNCT
eurjchem-2615	7	24	isoniazid	isoniazid	NOUN
eurjchem-2615	7	25	,	,	PUNCT
eurjchem-2615	7	26	quinoline	quinoline	NOUN
eurjchem-2615	7	27	/	/	SYM
eurjchem-2615	7	28	dihydroquinoline	dihydroquinoline	NOUN
eurjchem-2615	7	29	,	,	PUNCT
eurjchem-2615	7	30	quinolone	quinolone	NOUN
eurjchem-2615	7	31	,	,	PUNCT
eurjchem-2615	7	32	ferrocene	ferrocene	NOUN
eurjchem-2615	7	33	,	,	PUNCT
eurjchem-2615	7	34	isatin	isatin	PROPN
eurjchem-2615	7	35	,	,	PUNCT
eurjchem-2615	7	36	furan	furan	PROPN
eurjchem-2615	7	37	,	,	PUNCT
eurjchem-2615	7	38	and	and	CCONJ
eurjchem-2615	7	39	other	other	ADJ
eurjchem-2615	7	40	structures	structure	NOUN
eurjchem-2615	7	41	.	.	PUNCT
eurjchem-2615	8	1	these	these	DET
eurjchem-2615	8	2	hybrid	hybrid	ADJ
eurjchem-2615	8	3	molecules	molecule	NOUN
eurjchem-2615	8	4	generally	generally	ADV
eurjchem-2615	8	5	show	show	VERB
eurjchem-2615	8	6	improved	improved	ADJ
eurjchem-2615	8	7	potency	potency	NOUN
eurjchem-2615	8	8	against	against	ADP
eurjchem-2615	8	9	both	both	DET
eurjchem-2615	8	10	drug	drug	NOUN
eurjchem-2615	8	11	-	-	PUNCT
eurjchem-2615	8	12	sensitive	sensitive	ADJ
eurjchem-2615	8	13	and	and	CCONJ
eurjchem-2615	8	14	drug	drug	NOUN
eurjchem-2615	8	15	-	-	PUNCT
eurjchem-2615	8	16	resistant	resistant	ADJ
eurjchem-2615	8	17	mycobacterium	mycobacterium	NOUN
eurjchem-2615	8	18	tuberculosis	tuberculosis	NOUN
eurjchem-2615	8	19	strains	strain	NOUN
eurjchem-2615	8	20	while	while	SCONJ
eurjchem-2615	8	21	maintaining	maintain	VERB
eurjchem-2615	8	22	favorable	favorable	ADJ
eurjchem-2615	8	23	toxicity	toxicity	NOUN
eurjchem-2615	8	24	profiles	profile	NOUN
eurjchem-2615	8	25	,	,	PUNCT
eurjchem-2615	8	26	making	make	VERB
eurjchem-2615	8	27	them	they	PRON
eurjchem-2615	8	28	particularly	particularly	ADV
eurjchem-2615	8	29	valuable	valuable	ADJ
eurjchem-2615	8	30	in	in	ADP
eurjchem-2615	8	31	the	the	DET
eurjchem-2615	8	32	current	current	ADJ
eurjchem-2615	8	33	landscape	landscape	NOUN
eurjchem-2615	8	34	of	of	ADP
eurjchem-2615	8	35	rising	rise	VERB
eurjchem-2615	8	36	drug	drug	NOUN
eurjchem-2615	8	37	resistance	resistance	NOUN
eurjchem-2615	8	38	.	.	PUNCT
eurjchem-2615	9	1	structure	structure	NOUN
eurjchem-2615	9	2	-	-	PUNCT
eurjchem-2615	9	3	activity	activity	NOUN
eurjchem-2615	9	4	relationship	relationship	NOUN
eurjchem-2615	9	5	(	(	PUNCT
eurjchem-2615	9	6	sar	sar	PROPN
eurjchem-2615	9	7	)	)	PUNCT
eurjchem-2615	9	8	studies	study	NOUN
eurjchem-2615	9	9	highlight	highlight	VERB
eurjchem-2615	9	10	that	that	DET
eurjchem-2615	9	11	strategic	strategic	ADJ
eurjchem-2615	9	12	substituent	substituent	NOUN
eurjchem-2615	9	13	positioning	positioning	NOUN
eurjchem-2615	9	14	and	and	CCONJ
eurjchem-2615	9	15	optimal	optimal	ADJ
eurjchem-2615	9	16	linker	linker	NOUN
eurjchem-2615	9	17	selection	selection	NOUN
eurjchem-2615	9	18	are	be	AUX
eurjchem-2615	9	19	critical	critical	ADJ
eurjchem-2615	9	20	in	in	ADP
eurjchem-2615	9	21	enhancing	enhance	VERB
eurjchem-2615	9	22	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	9	23	efficacy	efficacy	NOUN
eurjchem-2615	9	24	.	.	PUNCT
eurjchem-2615	10	1	furthermore	furthermore	ADV
eurjchem-2615	10	2	,	,	PUNCT
eurjchem-2615	10	3	modifications	modification	NOUN
eurjchem-2615	10	4	to	to	ADP
eurjchem-2615	10	5	the	the	DET
eurjchem-2615	10	6	electronic	electronic	ADJ
eurjchem-2615	10	7	and	and	CCONJ
eurjchem-2615	10	8	steric	steric	ADJ
eurjchem-2615	10	9	properties	property	NOUN
eurjchem-2615	10	10	of	of	ADP
eurjchem-2615	10	11	the	the	DET
eurjchem-2615	10	12	hybrids	hybrid	NOUN
eurjchem-2615	10	13	have	have	AUX
eurjchem-2615	10	14	been	be	AUX
eurjchem-2615	10	15	shown	show	VERB
eurjchem-2615	10	16	to	to	PART
eurjchem-2615	10	17	influence	influence	VERB
eurjchem-2615	10	18	their	their	PRON
eurjchem-2615	10	19	ability	ability	NOUN
eurjchem-2615	10	20	to	to	PART
eurjchem-2615	10	21	bypass	bypass	VERB
eurjchem-2615	10	22	common	common	ADJ
eurjchem-2615	10	23	resistance	resistance	NOUN
eurjchem-2615	10	24	mechanisms	mechanism	NOUN
eurjchem-2615	10	25	,	,	PUNCT
eurjchem-2615	10	26	underscoring	underscore	VERB
eurjchem-2615	10	27	the	the	DET
eurjchem-2615	10	28	potential	potential	NOUN
eurjchem-2615	10	29	of	of	ADP
eurjchem-2615	10	30	these	these	DET
eurjchem-2615	10	31	compounds	compound	NOUN
eurjchem-2615	10	32	to	to	PART
eurjchem-2615	10	33	overcome	overcome	VERB
eurjchem-2615	10	34	treatment	treatment	NOUN
eurjchem-2615	10	35	barriers	barrier	NOUN
eurjchem-2615	10	36	.	.	PUNCT
eurjchem-2615	11	1	in	in	ADP
eurjchem-2615	11	2	particular	particular	ADJ
eurjchem-2615	11	3	,	,	PUNCT
eurjchem-2615	11	4	several	several	ADJ
eurjchem-2615	11	5	of	of	ADP
eurjchem-2615	11	6	these	these	DET
eurjchem-2615	11	7	hybrids	hybrid	NOUN
eurjchem-2615	11	8	demonstrate	demonstrate	VERB
eurjchem-2615	11	9	promising	promising	ADJ
eurjchem-2615	11	10	activity	activity	NOUN
eurjchem-2615	11	11	against	against	ADP
eurjchem-2615	11	12	mdr	mdr	PROPN
eurjchem-2615	11	13	-	-	PROPN
eurjchem-2615	11	14	tb	tb	PROPN
eurjchem-2615	11	15	and	and	CCONJ
eurjchem-2615	11	16	xdr	xdr	PROPN
eurjchem-2615	11	17	-	-	PUNCT
eurjchem-2615	11	18	tb	tb	NOUN
eurjchem-2615	11	19	strains	strain	NOUN
eurjchem-2615	11	20	,	,	PUNCT
eurjchem-2615	11	21	suggesting	suggest	VERB
eurjchem-2615	11	22	potential	potential	ADJ
eurjchem-2615	11	23	applications	application	NOUN
eurjchem-2615	11	24	for	for	ADP
eurjchem-2615	11	25	immunocompromised	immunocompromise	VERB
eurjchem-2615	11	26	patients	patient	NOUN
eurjchem-2615	11	27	,	,	PUNCT
eurjchem-2615	11	28	such	such	ADJ
eurjchem-2615	11	29	as	as	ADP
eurjchem-2615	11	30	those	those	PRON
eurjchem-2615	11	31	with	with	ADP
eurjchem-2615	11	32	hiv	hiv	PROPN
eurjchem-2615	11	33	co	co	NOUN
eurjchem-2615	11	34	-	-	NOUN
eurjchem-2615	11	35	infection	infection	NOUN
eurjchem-2615	11	36	.	.	PUNCT
eurjchem-2615	12	1	collectively	collectively	ADV
eurjchem-2615	12	2	,	,	PUNCT
eurjchem-2615	12	3	these	these	DET
eurjchem-2615	12	4	findings	finding	NOUN
eurjchem-2615	12	5	offer	offer	VERB
eurjchem-2615	12	6	valuable	valuable	ADJ
eurjchem-2615	12	7	insights	insight	NOUN
eurjchem-2615	12	8	for	for	ADP
eurjchem-2615	12	9	the	the	DET
eurjchem-2615	12	10	rational	rational	ADJ
eurjchem-2615	12	11	design	design	NOUN
eurjchem-2615	12	12	of	of	ADP
eurjchem-2615	12	13	next	next	ADJ
eurjchem-2615	12	14	-	-	PUNCT
eurjchem-2615	12	15	generation	generation	NOUN
eurjchem-2615	12	16	antituberculosis	antituberculosis	NOUN
eurjchem-2615	12	17	agents	agent	NOUN
eurjchem-2615	12	18	that	that	PRON
eurjchem-2615	12	19	could	could	AUX
eurjchem-2615	12	20	transform	transform	VERB
eurjchem-2615	12	21	tuberculosis	tuberculosis	NOUN
eurjchem-2615	12	22	(	(	PUNCT
eurjchem-2615	12	23	tb	tb	NOUN
eurjchem-2615	12	24	)	)	PUNCT
eurjchem-2615	12	25	treatment	treatment	NOUN
eurjchem-2615	12	26	paradigms	paradigm	NOUN
eurjchem-2615	12	27	in	in	ADP
eurjchem-2615	12	28	both	both	CCONJ
eurjchem-2615	12	29	resistant	resistant	ADJ
eurjchem-2615	12	30	and	and	CCONJ
eurjchem-2615	12	31	sensitive	sensitive	ADJ
eurjchem-2615	12	32	cases	case	NOUN
eurjchem-2615	12	33	of	of	ADP
eurjchem-2615	12	34	tb	tb	NOUN
eurjchem-2615	12	35	.	.	PUNCT
eurjchem-2615	12	36	cuaac	cuaac	VERB
eurjchem-2615	12	37	1,2,3	1,2,3	NUM
eurjchem-2615	12	38	-	-	PUNCT
eurjchem-2615	12	39	triazoles	triazole	NOUN
eurjchem-2615	12	40	click	click	VERB
eurjchem-2615	12	41	chemistry	chemistry	NOUN
eurjchem-2615	12	42	drug	drug	NOUN
eurjchem-2615	12	43	discovery	discovery	PROPN
eurjchem-2615	12	44	medicinal	medicinal	ADJ
eurjchem-2615	12	45	chemistry	chemistry	NOUN
eurjchem-2615	12	46	mycobacterium	mycobacterium	NOUN
eurjchem-2615	12	47	tuberculosis	tuberculosis	NOUN
eurjchem-2615	12	48	cite	cite	VERB
eurjchem-2615	12	49	this	this	PRON
eurjchem-2615	12	50	:	:	PUNCT
eurjchem-2615	12	51	eur	eur	PROPN
eurjchem-2615	12	52	.	.	PUNCT
eurjchem-2615	13	1	j.	j.	PROPN
eurjchem-2615	13	2	chem	chem	PROPN
eurjchem-2615	13	3	.	.	PUNCT
eurjchem-2615	14	1	2025	2025	NUM
eurjchem-2615	14	2	,	,	PUNCT
eurjchem-2615	14	3	16(1	16(1	NUM
eurjchem-2615	14	4	)	)	PUNCT
eurjchem-2615	14	5	,	,	PUNCT
eurjchem-2615	14	6	83	83	NUM
eurjchem-2615	14	7	-	-	SYM
eurjchem-2615	14	8	96	96	NUM
eurjchem-2615	14	9	journal	journal	NOUN
eurjchem-2615	14	10	website	website	NOUN
eurjchem-2615	14	11	:	:	PUNCT
eurjchem-2615	14	12	www.eurjchem.com	www.eurjchem.com	X
eurjchem-2615	14	13	1	1	X
eurjchem-2615	14	14	.	.	PUNCT
eurjchem-2615	14	15	introduction	introduction	NOUN
eurjchem-2615	14	16	tuberculosis	tuberculosis	NOUN
eurjchem-2615	14	17	,	,	PUNCT
eurjchem-2615	14	18	a	a	DET
eurjchem-2615	14	19	bacterial	bacterial	ADJ
eurjchem-2615	14	20	infection	infection	NOUN
eurjchem-2615	14	21	caused	cause	VERB
eurjchem-2615	14	22	by	by	ADP
eurjchem-2615	14	23	mycobacterium	mycobacterium	NOUN
eurjchem-2615	14	24	tuberculosis	tuberculosis	NOUN
eurjchem-2615	14	25	,	,	PUNCT
eurjchem-2615	14	26	is	be	AUX
eurjchem-2615	14	27	one	one	NUM
eurjchem-2615	14	28	of	of	ADP
eurjchem-2615	14	29	the	the	DET
eurjchem-2615	14	30	oldest	old	ADJ
eurjchem-2615	14	31	known	know	VERB
eurjchem-2615	14	32	diseases	disease	NOUN
eurjchem-2615	14	33	,	,	PUNCT
eurjchem-2615	14	34	with	with	ADP
eurjchem-2615	14	35	a	a	DET
eurjchem-2615	14	36	global	global	ADJ
eurjchem-2615	14	37	mortality	mortality	NOUN
eurjchem-2615	14	38	rate	rate	NOUN
eurjchem-2615	14	39	higher	high	ADJ
eurjchem-2615	14	40	than	than	ADP
eurjchem-2615	14	41	that	that	PRON
eurjchem-2615	14	42	of	of	ADP
eurjchem-2615	14	43	aids	aid	NOUN
eurjchem-2615	14	44	and	and	CCONJ
eurjchem-2615	14	45	a	a	DET
eurjchem-2615	14	46	high	high	ADJ
eurjchem-2615	14	47	prevalence	prevalence	NOUN
eurjchem-2615	14	48	among	among	ADP
eurjchem-2615	14	49	socioeconomically	socioeconomically	ADV
eurjchem-2615	14	50	disadvantaged	disadvantaged	ADJ
eurjchem-2615	14	51	and	and	CCONJ
eurjchem-2615	14	52	marginalized	marginalize	VERB
eurjchem-2615	14	53	groups	group	NOUN
eurjchem-2615	14	54	[	[	X
eurjchem-2615	14	55	1,2	1,2	NUM
eurjchem-2615	14	56	]	]	PUNCT
eurjchem-2615	14	57	.	.	PUNCT
eurjchem-2615	15	1	despite	despite	SCONJ
eurjchem-2615	15	2	decades	decade	NOUN
eurjchem-2615	15	3	of	of	ADP
eurjchem-2615	15	4	research	research	NOUN
eurjchem-2615	15	5	and	and	CCONJ
eurjchem-2615	15	6	intervention	intervention	NOUN
eurjchem-2615	15	7	programs	program	NOUN
eurjchem-2615	15	8	,	,	PUNCT
eurjchem-2615	15	9	tuberculosis	tuberculosis	NOUN
eurjchem-2615	15	10	remains	remain	VERB
eurjchem-2615	15	11	the	the	DET
eurjchem-2615	15	12	leading	lead	VERB
eurjchem-2615	15	13	cause	cause	NOUN
eurjchem-2615	15	14	of	of	ADP
eurjchem-2615	15	15	death	death	NOUN
eurjchem-2615	15	16	from	from	ADP
eurjchem-2615	15	17	a	a	DET
eurjchem-2615	15	18	single	single	ADJ
eurjchem-2615	15	19	infectious	infectious	ADJ
eurjchem-2615	15	20	agent	agent	NOUN
eurjchem-2615	15	21	.	.	PUNCT
eurjchem-2615	16	1	the	the	DET
eurjchem-2615	16	2	disease	disease	NOUN
eurjchem-2615	16	3	mainly	mainly	ADV
eurjchem-2615	16	4	affects	affect	VERB
eurjchem-2615	16	5	the	the	DET
eurjchem-2615	16	6	lungs	lung	NOUN
eurjchem-2615	16	7	(	(	PUNCT
eurjchem-2615	16	8	pulmonary	pulmonary	ADJ
eurjchem-2615	16	9	tuberculosis	tuberculosis	NOUN
eurjchem-2615	16	10	)	)	PUNCT
eurjchem-2615	16	11	but	but	CCONJ
eurjchem-2615	16	12	can	can	AUX
eurjchem-2615	16	13	also	also	ADV
eurjchem-2615	16	14	affect	affect	VERB
eurjchem-2615	16	15	other	other	ADJ
eurjchem-2615	16	16	organs	organ	NOUN
eurjchem-2615	16	17	(	(	PUNCT
eurjchem-2615	16	18	extrapulmonary	extrapulmonary	NOUN
eurjchem-2615	16	19	tuberculosis	tuberculosis	NOUN
eurjchem-2615	16	20	)	)	PUNCT
eurjchem-2615	17	1	[	[	X
eurjchem-2615	17	2	3	3	NUM
eurjchem-2615	17	3	]	]	PUNCT
eurjchem-2615	17	4	.	.	PUNCT
eurjchem-2615	18	1	the	the	DET
eurjchem-2615	18	2	emergence	emergence	NOUN
eurjchem-2615	18	3	of	of	ADP
eurjchem-2615	18	4	drug	drug	NOUN
eurjchem-2615	18	5	-	-	PUNCT
eurjchem-2615	18	6	resistant	resistant	ADJ
eurjchem-2615	18	7	strains	strain	NOUN
eurjchem-2615	18	8	,	,	PUNCT
eurjchem-2615	18	9	particularly	particularly	ADV
eurjchem-2615	18	10	multiple	multiple	ADJ
eurjchem-2615	18	11	drug	drug	NOUN
eurjchem-2615	18	12	-	-	PUNCT
eurjchem-2615	18	13	resistant	resistant	ADJ
eurjchem-2615	18	14	tb	tb	X
eurjchem-2615	18	15	(	(	PUNCT
eurjchem-2615	18	16	mdr	mdr	PROPN
eurjchem-2615	18	17	-	-	NOUN
eurjchem-2615	18	18	tb	tb	NOUN
eurjchem-2615	18	19	)	)	PUNCT
eurjchem-2615	18	20	and	and	CCONJ
eurjchem-2615	18	21	extensively	extensively	ADV
eurjchem-2615	18	22	drugresistant	drugresistant	NOUN
eurjchem-2615	18	23	tb	tb	X
eurjchem-2615	18	24	(	(	PUNCT
eurjchem-2615	18	25	xdr	xdr	PROPN
eurjchem-2615	18	26	-	-	PUNCT
eurjchem-2615	18	27	tb	tb	NOUN
eurjchem-2615	18	28	)	)	PUNCT
eurjchem-2615	18	29	,	,	PUNCT
eurjchem-2615	18	30	has	have	VERB
eurjchem-2615	18	31	complicated	complicate	VERB
eurjchem-2615	18	32	treatment	treatment	NOUN
eurjchem-2615	18	33	protocols	protocol	NOUN
eurjchem-2615	18	34	and	and	CCONJ
eurjchem-2615	18	35	reduced	reduce	VERB
eurjchem-2615	18	36	success	success	NOUN
eurjchem-2615	18	37	rates	rate	NOUN
eurjchem-2615	18	38	.	.	PUNCT
eurjchem-2615	19	1	in	in	ADP
eurjchem-2615	19	2	2024	2024	NUM
eurjchem-2615	19	3	,	,	PUNCT
eurjchem-2615	19	4	approximately	approximately	ADV
eurjchem-2615	19	5	484,000	484,000	NUM
eurjchem-2615	19	6	cases	case	NOUN
eurjchem-2615	19	7	of	of	ADP
eurjchem-2615	19	8	mdr	mdr	PROPN
eurjchem-2615	19	9	-	-	PROPN
eurjchem-2615	19	10	tb	tb	PROPN
eurjchem-2615	19	11	were	be	AUX
eurjchem-2615	19	12	reported	report	VERB
eurjchem-2615	19	13	worldwide	worldwide	ADV
eurjchem-2615	19	14	,	,	PUNCT
eurjchem-2615	19	15	highlighting	highlight	VERB
eurjchem-2615	19	16	the	the	DET
eurjchem-2615	19	17	urgent	urgent	ADJ
eurjchem-2615	19	18	need	need	NOUN
eurjchem-2615	19	19	for	for	ADP
eurjchem-2615	19	20	innovative	innovative	ADJ
eurjchem-2615	19	21	therapeutic	therapeutic	ADJ
eurjchem-2615	19	22	approaches	approach	NOUN
eurjchem-2615	19	23	[	[	X
eurjchem-2615	19	24	4	4	NUM
eurjchem-2615	19	25	]	]	PUNCT
eurjchem-2615	19	26	.	.	PUNCT
eurjchem-2615	20	1	the	the	DET
eurjchem-2615	20	2	who	who	PRON
eurjchem-2615	20	3	-	-	PUNCT
eurjchem-2615	20	4	recommended	recommend	VERB
eurjchem-2615	20	5	tb	tb	ADP
eurjchem-2615	20	6	treatment	treatment	NOUN
eurjchem-2615	20	7	regimens	regimen	NOUN
eurjchem-2615	20	8	face	face	VERB
eurjchem-2615	20	9	significant	significant	ADJ
eurjchem-2615	20	10	challenges	challenge	NOUN
eurjchem-2615	20	11	[	[	X
eurjchem-2615	20	12	5	5	NUM
eurjchem-2615	20	13	]	]	PUNCT
eurjchem-2615	20	14	.	.	PUNCT
eurjchem-2615	21	1	drug	drug	NOUN
eurjchem-2615	21	2	-	-	PUNCT
eurjchem-2615	21	3	sensitive	sensitive	ADJ
eurjchem-2615	21	4	tuberculosis	tuberculosis	NOUN
eurjchem-2615	21	5	requires	require	VERB
eurjchem-2615	21	6	6	6	NUM
eurjchem-2615	21	7	-	-	SYM
eurjchem-2615	21	8	8	8	NUM
eurjchem-2615	21	9	months	month	NOUN
eurjchem-2615	21	10	of	of	ADP
eurjchem-2615	21	11	first	first	ADJ
eurjchem-2615	21	12	-	-	PUNCT
eurjchem-2615	21	13	line	line	NOUN
eurjchem-2615	21	14	therapy	therapy	NOUN
eurjchem-2615	21	15	,	,	PUNCT
eurjchem-2615	21	16	leading	lead	VERB
eurjchem-2615	21	17	to	to	ADP
eurjchem-2615	21	18	poor	poor	ADJ
eurjchem-2615	21	19	patient	patient	ADJ
eurjchem-2615	21	20	compliance	compliance	NOUN
eurjchem-2615	21	21	and	and	CCONJ
eurjchem-2615	21	22	potential	potential	ADJ
eurjchem-2615	21	23	development	development	NOUN
eurjchem-2615	21	24	of	of	ADP
eurjchem-2615	21	25	mdr	mdr	PROPN
eurjchem-2615	21	26	tuberculosis	tuberculosis	NOUN
eurjchem-2615	21	27	.	.	PUNCT
eurjchem-2615	22	1	treatment	treatment	NOUN
eurjchem-2615	22	2	of	of	ADP
eurjchem-2615	22	3	mdrtb	mdrtb	NOUN
eurjchem-2615	22	4	and	and	CCONJ
eurjchem-2615	22	5	xdr	xdr	PROPN
eurjchem-2615	22	6	-	-	PUNCT
eurjchem-2615	22	7	tb	tb	NOUN
eurjchem-2615	22	8	requires	require	VERB
eurjchem-2615	22	9	more	more	ADV
eurjchem-2615	22	10	expensive	expensive	ADJ
eurjchem-2615	22	11	,	,	PUNCT
eurjchem-2615	22	12	more	more	ADV
eurjchem-2615	22	13	toxic	toxic	ADJ
eurjchem-2615	22	14	and	and	CCONJ
eurjchem-2615	22	15	less	less	ADV
eurjchem-2615	22	16	effective	effective	ADJ
eurjchem-2615	22	17	secondand	secondand	NOUN
eurjchem-2615	22	18	third	third	ADJ
eurjchem-2615	22	19	-	-	PUNCT
eurjchem-2615	22	20	line	line	NOUN
eurjchem-2615	22	21	drugs	drug	NOUN
eurjchem-2615	22	22	with	with	ADP
eurjchem-2615	22	23	extended	extended	ADJ
eurjchem-2615	22	24	treatment	treatment	NOUN
eurjchem-2615	22	25	durations	duration	NOUN
eurjchem-2615	22	26	.	.	PUNCT
eurjchem-2615	23	1	additional	additional	ADJ
eurjchem-2615	23	2	complications	complication	NOUN
eurjchem-2615	23	3	arise	arise	VERB
eurjchem-2615	23	4	from	from	ADP
eurjchem-2615	23	5	drug	drug	NOUN
eurjchem-2615	23	6	interactions	interaction	NOUN
eurjchem-2615	23	7	between	between	ADP
eurjchem-2615	23	8	tb	tb	ADP
eurjchem-2615	23	9	medications	medication	NOUN
eurjchem-2615	23	10	and	and	CCONJ
eurjchem-2615	23	11	antiretroviral	antiretroviral	ADJ
eurjchem-2615	23	12	therapy	therapy	NOUN
eurjchem-2615	23	13	in	in	ADP
eurjchem-2615	23	14	hiv	hiv	PROPN
eurjchem-2615	23	15	/	/	SYM
eurjchem-2615	23	16	aids	aids	PROPN
eurjchem-2615	23	17	patients	patient	NOUN
eurjchem-2615	23	18	,	,	PUNCT
eurjchem-2615	23	19	and	and	CCONJ
eurjchem-2615	23	20	the	the	DET
eurjchem-2615	23	21	difficulty	difficulty	NOUN
eurjchem-2615	23	22	in	in	ADP
eurjchem-2615	23	23	identifying	identify	VERB
eurjchem-2615	23	24	and	and	CCONJ
eurjchem-2615	23	25	treating	treat	VERB
eurjchem-2615	23	26	latent	latent	NOUN
eurjchem-2615	23	27	tb	tb	NOUN
eurjchem-2615	23	28	before	before	SCONJ
eurjchem-2615	23	29	an	an	DET
eurjchem-2615	23	30	active	active	ADJ
eurjchem-2615	23	31	disease	disease	NOUN
eurjchem-2615	23	32	develops	develop	VERB
eurjchem-2615	23	33	[	[	X
eurjchem-2615	23	34	6	6	NUM
eurjchem-2615	23	35	]	]	PUNCT
eurjchem-2615	23	36	.	.	PUNCT
eurjchem-2615	24	1	the	the	DET
eurjchem-2615	24	2	interplay	interplay	NOUN
eurjchem-2615	24	3	between	between	ADP
eurjchem-2615	24	4	tb	tb	NOUN
eurjchem-2615	24	5	and	and	CCONJ
eurjchem-2615	24	6	hiv	hiv	PROPN
eurjchem-2615	24	7	greatly	greatly	ADV
eurjchem-2615	24	8	intensifies	intensify	VERB
eurjchem-2615	24	9	the	the	DET
eurjchem-2615	24	10	public	public	ADJ
eurjchem-2615	24	11	health	health	NOUN
eurjchem-2615	24	12	challenge	challenge	NOUN
eurjchem-2615	24	13	,	,	PUNCT
eurjchem-2615	24	14	with	with	ADP
eurjchem-2615	24	15	hiv	hiv	PROPN
eurjchem-2615	24	16	-	-	PUNCT
eurjchem-2615	24	17	positive	positive	ADJ
eurjchem-2615	24	18	individuals	individual	NOUN
eurjchem-2615	24	19	facing	face	VERB
eurjchem-2615	24	20	an	an	DET
eurjchem-2615	24	21	18	18	NUM
eurjchem-2615	24	22	-	-	ADJ
eurjchem-2615	24	23	fold	fold	ADJ
eurjchem-2615	24	24	higher	high	ADJ
eurjchem-2615	24	25	risk	risk	NOUN
eurjchem-2615	24	26	of	of	ADP
eurjchem-2615	24	27	developing	develop	VERB
eurjchem-2615	24	28	active	active	ADJ
eurjchem-2615	24	29	tb	tb	NOUN
eurjchem-2615	24	30	.	.	PUNCT
eurjchem-2615	25	1	furthermore	furthermore	ADV
eurjchem-2615	25	2	,	,	PUNCT
eurjchem-2615	25	3	the	the	DET
eurjchem-2615	25	4	covid-19	covid-19	PROPN
eurjchem-2615	25	5	pandemic	pandemic	NOUN
eurjchem-2615	25	6	has	have	AUX
eurjchem-2615	25	7	severely	severely	ADV
eurjchem-2615	25	8	impacted	impact	VERB
eurjchem-2615	25	9	tb	tb	ADP
eurjchem-2615	25	10	services	service	NOUN
eurjchem-2615	25	11	globally	globally	ADV
eurjchem-2615	25	12	,	,	PUNCT
eurjchem-2615	25	13	undoing	undo	VERB
eurjchem-2615	25	14	years	year	NOUN
eurjchem-2615	25	15	of	of	ADP
eurjchem-2615	25	16	progress	progress	NOUN
eurjchem-2615	25	17	in	in	ADP
eurjchem-2615	25	18	tb	tb	ADP
eurjchem-2615	25	19	control	control	NOUN
eurjchem-2615	25	20	.	.	PUNCT
eurjchem-2615	26	1	the	the	DET
eurjchem-2615	26	2	world	world	PROPN
eurjchem-2615	26	3	health	health	PROPN
eurjchem-2615	26	4	organization	organization	NOUN
eurjchem-2615	26	5	estimates	estimate	VERB
eurjchem-2615	26	6	that	that	SCONJ
eurjchem-2615	26	7	disruptions	disruption	NOUN
eurjchem-2615	26	8	due	due	ADP
eurjchem-2615	26	9	to	to	ADP
eurjchem-2615	26	10	the	the	DET
eurjchem-2615	26	11	pandemic	pandemic	NOUN
eurjchem-2615	26	12	have	have	AUX
eurjchem-2615	26	13	resulted	result	VERB
eurjchem-2615	26	14	in	in	ADP
eurjchem-2615	26	15	a	a	DET
eurjchem-2615	26	16	20	20	NUM
eurjchem-2615	26	17	%	%	NOUN
eurjchem-2615	26	18	increase	increase	NOUN
eurjchem-2615	26	19	in	in	ADP
eurjchem-2615	26	20	tuberculosis	tuberculosis	NOUN
eurjchem-2615	26	21	deaths	death	NOUN
eurjchem-2615	26	22	from	from	ADP
eurjchem-2615	26	23	2020	2020	NUM
eurjchem-2615	26	24	to	to	ADP
eurjchem-2615	26	25	2024	2024	NUM
eurjchem-2615	26	26	[	[	X
eurjchem-2615	26	27	7,8	7,8	NUM
eurjchem-2615	26	28	]	]	PUNCT
eurjchem-2615	26	29	.	.	PUNCT
eurjchem-2615	27	1	click	click	VERB
eurjchem-2615	27	2	chemistry	chemistry	NOUN
eurjchem-2615	27	3	represents	represent	VERB
eurjchem-2615	27	4	a	a	DET
eurjchem-2615	27	5	groundbreaking	groundbreaking	ADJ
eurjchem-2615	27	6	paradigm	paradigm	NOUN
eurjchem-2615	27	7	in	in	ADP
eurjchem-2615	27	8	chemical	chemical	ADJ
eurjchem-2615	27	9	synthesis	synthesis	NOUN
eurjchem-2615	27	10	,	,	PUNCT
eurjchem-2615	27	11	comprising	comprise	VERB
eurjchem-2615	27	12	a	a	DET
eurjchem-2615	27	13	suite	suite	NOUN
eurjchem-2615	27	14	of	of	ADP
eurjchem-2615	27	15	highly	highly	ADV
eurjchem-2615	27	16	efficient	efficient	ADJ
eurjchem-2615	27	17	,	,	PUNCT
eurjchem-2615	27	18	selective	selective	ADJ
eurjchem-2615	27	19	,	,	PUNCT
eurjchem-2615	27	20	and	and	CCONJ
eurjchem-2615	27	21	modular	modular	ADJ
eurjchem-2615	27	22	reactions	reaction	NOUN
eurjchem-2615	27	23	that	that	PRON
eurjchem-2615	27	24	proceed	proceed	VERB
eurjchem-2615	27	25	rapidly	rapidly	ADV
eurjchem-2615	27	26	under	under	ADP
eurjchem-2615	27	27	mild	mild	ADJ
eurjchem-2615	27	28	conditions	condition	NOUN
eurjchem-2615	27	29	to	to	PART
eurjchem-2615	27	30	form	form	VERB
eurjchem-2615	27	31	covalent	covalent	ADJ
eurjchem-2615	27	32	bonds	bond	NOUN
eurjchem-2615	27	33	between	between	ADP
eurjchem-2615	27	34	molecular	molecular	ADJ
eurjchem-2615	27	35	building	building	NOUN
eurjchem-2615	27	36	blocks	block	NOUN
eurjchem-2615	28	1	[	[	X
eurjchem-2615	28	2	9	9	NUM
eurjchem-2615	28	3	-	-	SYM
eurjchem-2615	28	4	11	11	NUM
eurjchem-2615	28	5	]	]	PUNCT
eurjchem-2615	28	6	.	.	PUNCT
eurjchem-2615	29	1	the	the	DET
eurjchem-2615	29	2	copper(i)-catalyzed	copper(i)-catalyze	VERB
eurjchem-2615	29	3	azide	azide	NOUN
eurjchem-2615	29	4	-	-	PUNCT
eurjchem-2615	29	5	alkyne	alkyne	NOUN
eurjchem-2615	29	6	cycloaddition	cycloaddition	NOUN
eurjchem-2615	29	7	(	(	PUNCT
eurjchem-2615	29	8	cuaac	cuaac	NOUN
eurjchem-2615	29	9	)	)	PUNCT
eurjchem-2615	29	10	reaction	reaction	NOUN
eurjchem-2615	29	11	,	,	PUNCT
eurjchem-2615	29	12	the	the	DET
eurjchem-2615	29	13	quintessential	quintessential	ADJ
eurjchem-2615	29	14	example	example	NOUN
eurjchem-2615	29	15	of	of	ADP
eurjchem-2615	29	16	click	click	VERB
eurjchem-2615	29	17	chemistry	chemistry	NOUN
eurjchem-2615	29	18	,	,	PUNCT
eurjchem-2615	29	19	has	have	AUX
eurjchem-2615	29	20	revolutionized	revolutionize	VERB
eurjchem-2615	29	21	diverse	diverse	ADJ
eurjchem-2615	29	22	fields	field	NOUN
eurjchem-2615	29	23	,	,	PUNCT
eurjchem-2615	29	24	including	include	VERB
eurjchem-2615	29	25	drug	drug	NOUN
eurjchem-2615	29	26	discovery	discovery	NOUN
eurjchem-2615	30	1	[	[	X
eurjchem-2615	30	2	12	12	NUM
eurjchem-2615	30	3	-	-	SYM
eurjchem-2615	30	4	16	16	NUM
eurjchem-2615	30	5	]	]	PUNCT
eurjchem-2615	30	6	,	,	PUNCT
eurjchem-2615	30	7	materials	material	NOUN
eurjchem-2615	30	8	science	science	NOUN
eurjchem-2615	30	9	[	[	X
eurjchem-2615	30	10	17	17	NUM
eurjchem-2615	30	11	]	]	PUNCT
eurjchem-2615	30	12	,	,	PUNCT
eurjchem-2615	30	13	and	and	CCONJ
eurjchem-2615	30	14	bioconjugation	bioconjugation	NOUN
eurjchem-2615	31	1	[	[	X
eurjchem-2615	31	2	18	18	NUM
eurjchem-2615	31	3	-	-	SYM
eurjchem-2615	31	4	20	20	NUM
eurjchem-2615	31	5	]	]	PUNCT
eurjchem-2615	31	6	.	.	PUNCT
eurjchem-2615	32	1	this	this	DET
eurjchem-2615	32	2	methodology	methodology	NOUN
eurjchem-2615	32	3	,	,	PUNCT
eurjchem-2615	32	4	first	first	ADV
eurjchem-2615	32	5	conceptualized	conceptualize	VERB
eurjchem-2615	32	6	by	by	ADP
eurjchem-2615	32	7	sharpless	sharpless	NOUN
eurjchem-2615	32	8	and	and	CCONJ
eurjchem-2615	32	9	colleagues	colleague	NOUN
eurjchem-2615	32	10	,	,	PUNCT
eurjchem-2615	32	11	is	be	AUX
eurjchem-2615	32	12	characterized	characterize	VERB
eurjchem-2615	32	13	by	by	ADP
eurjchem-2615	32	14	stringent	stringent	ADJ
eurjchem-2615	32	15	criteria	criterion	NOUN
eurjchem-2615	32	16	:	:	PUNCT
eurjchem-2615	32	17	stereospecificity	stereospecificity	NOUN
eurjchem-2615	32	18	,	,	PUNCT
eurjchem-2615	32	19	high	high	ADJ
eurjchem-2615	32	20	yields	yield	NOUN
eurjchem-2615	32	21	,	,	PUNCT
eurjchem-2615	32	22	simple	simple	ADJ
eurjchem-2615	32	23	reaction	reaction	NOUN
eurjchem-2615	32	24	conditions	condition	NOUN
eurjchem-2615	32	25	,	,	PUNCT
eurjchem-2615	32	26	readily	readily	ADV
eurjchem-2615	32	27	available	available	ADJ
eurjchem-2615	32	28	starting	start	VERB
eurjchem-2615	32	29	materials	material	NOUN
eurjchem-2615	32	30	,	,	PUNCT
eurjchem-2615	32	31	and	and	CCONJ
eurjchem-2615	32	32	environmentally	environmentally	ADV
eurjchem-2615	32	33	benign	benign	ADJ
eurjchem-2615	32	34	solvents	solvent	NOUN
eurjchem-2615	32	35	.	.	PUNCT
eurjchem-2615	33	1	in	in	ADP
eurjchem-2615	33	2	the	the	DET
eurjchem-2615	33	3	context	context	NOUN
eurjchem-2615	33	4	of	of	ADP
eurjchem-2615	33	5	tuberculosis	tuberculosis	NOUN
eurjchem-2615	33	6	research	research	NOUN
eurjchem-2615	33	7	,	,	PUNCT
eurjchem-2615	33	8	click	click	VERB
eurjchem-2615	33	9	chemistry	chemistry	NOUN
eurjchem-2615	33	10	has	have	AUX
eurjchem-2615	33	11	emerged	emerge	VERB
eurjchem-2615	33	12	as	as	ADP
eurjchem-2615	33	13	an	an	DET
eurjchem-2615	33	14	invaluable	invaluable	ADJ
eurjchem-2615	33	15	tool	tool	NOUN
eurjchem-2615	33	16	for	for	ADP
eurjchem-2615	33	17	developing	develop	VERB
eurjchem-2615	33	18	novel	novel	ADJ
eurjchem-2615	33	19	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	33	20	agents	agent	NOUN
eurjchem-2615	33	21	,	,	PUNCT
eurjchem-2615	33	22	particularly	particularly	ADV
eurjchem-2615	33	23	in	in	ADP
eurjchem-2615	33	24	the	the	DET
eurjchem-2615	33	25	modification	modification	NOUN
eurjchem-2615	33	26	abstract	abstract	ADJ
eurjchem-2615	33	27	review	review	NOUN
eurjchem-2615	33	28	article	article	NOUN
eurjchem-2615	33	29	keywords	keyword	VERB
eurjchem-2615	33	30	https://dx.doi.org/10.5155/eurjchem.16.1.83-96.2615	https://dx.doi.org/10.5155/eurjchem.16.1.83-96.2615	PROPN
eurjchem-2615	33	31	https://www.eurjchem.com/	https://www.eurjchem.com/	ADJ
eurjchem-2615	33	32	https://dx.doi.org/10.5155/eurjchem.16.1.83-96.2615	https://dx.doi.org/10.5155/eurjchem.16.1.83-96.2615	PROPN
eurjchem-2615	33	33	mailto:coghips@must.edu.mo	mailto:coghips@must.edu.mo	NOUN
eurjchem-2615	33	34	http://www.eurjchem.com/	http://www.eurjchem.com/	NOUN
eurjchem-2615	33	35	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.16.1.83-96.2615&domain=pdf&date_stamp=2025-03-31	https://crossmark.crossref.org/dialog/?doi=10.5155/eurjchem.16.1.83-96.2615&domain=pdf&date_stamp=2025-03-31	VERB
eurjchem-2615	33	36	84	84	NUM
eurjchem-2615	33	37	zimo	zimo	ADJ
eurjchem-2615	33	38	and	and	CCONJ
eurjchem-2615	33	39	coghi	coghi	PROPN
eurjchem-2615	33	40	/	/	SYM
eurjchem-2615	33	41	european	european	PROPN
eurjchem-2615	33	42	journal	journal	PROPN
eurjchem-2615	33	43	of	of	ADP
eurjchem-2615	33	44	chemistry	chemistry	NOUN
eurjchem-2615	33	45	16	16	NUM
eurjchem-2615	33	46	(	(	PUNCT
eurjchem-2615	33	47	1	1	NUM
eurjchem-2615	33	48	)	)	PUNCT
eurjchem-2615	33	49	(	(	PUNCT
eurjchem-2615	33	50	2025	2025	NUM
eurjchem-2615	33	51	)	)	PUNCT
eurjchem-2615	33	52	83	83	NUM
eurjchem-2615	33	53	-	-	SYM
eurjchem-2615	33	54	96	96	NUM
eurjchem-2615	33	55	2025	2025	NUM
eurjchem-2615	33	56	–	–	PUNCT
eurjchem-2615	33	57	european	european	ADJ
eurjchem-2615	33	58	journal	journal	NOUN
eurjchem-2615	33	59	of	of	ADP
eurjchem-2615	33	60	chemistry	chemistry	NOUN
eurjchem-2615	33	61	–	–	PUNCT
eurjchem-2615	33	62	cc	cc	NOUN
eurjchem-2615	33	63	by	by	ADP
eurjchem-2615	33	64	nc	nc	PROPN
eurjchem-2615	33	65	–	–	PUNCT
eurjchem-2615	33	66	doi	doi	NOUN
eurjchem-2615	33	67	:	:	PUNCT
eurjchem-2615	33	68	10.5155	10.5155	NUM
eurjchem-2615	33	69	/	/	SYM
eurjchem-2615	33	70	eurjchem.16.1.83	eurjchem.16.1.83	ADJ
eurjchem-2615	33	71	-	-	PUNCT
eurjchem-2615	33	72	96.2615	96.2615	NUM
eurjchem-2615	33	73	n	n	CCONJ
eurjchem-2615	33	74	n	n	CCONJ
eurjchem-2615	33	75	n	n	PROPN
eurjchem-2615	33	76	+	+	CCONJ
eurjchem-2615	33	77	cu	cu	PROPN
eurjchem-2615	33	78	catalyst	catalyst	NOUN
eurjchem-2615	33	79	n	n	CCONJ
eurjchem-2615	33	80	n	n	CCONJ
eurjchem-2615	33	81	n	n	CCONJ
eurjchem-2615	33	82	n	n	CCONJ
eurjchem-2615	33	83	n	n	CCONJ
eurjchem-2615	33	84	n	n	NOUN
eurjchem-2615	33	85	+	+	CCONJ
eurjchem-2615	33	86	n	n	CCONJ
eurjchem-2615	33	87	n	n	CCONJ
eurjchem-2615	33	88	n	n	CCONJ
eurjchem-2615	33	89	(	(	PUNCT
eurjchem-2615	33	90	a	a	PRON
eurjchem-2615	33	91	)	)	PUNCT
eurjchem-2615	33	92	cuaac	cuaac	NOUN
eurjchem-2615	33	93	(	(	PUNCT
eurjchem-2615	33	94	b	b	NOUN
eurjchem-2615	33	95	)	)	PUNCT
eurjchem-2615	33	96	spaac	spaac	ADJ
eurjchem-2615	33	97	figure	figure	NOUN
eurjchem-2615	33	98	1	1	NUM
eurjchem-2615	33	99	.	.	PUNCT
eurjchem-2615	34	1	(	(	PUNCT
eurjchem-2615	34	2	a	a	X
eurjchem-2615	34	3	)	)	PUNCT
eurjchem-2615	34	4	cu	cu	NOUN
eurjchem-2615	34	5	-	-	PUNCT
eurjchem-2615	34	6	catalyzed	catalyze	VERB
eurjchem-2615	34	7	azide	azide	NOUN
eurjchem-2615	34	8	-	-	PUNCT
eurjchem-2615	34	9	alkyne	alkyne	NOUN
eurjchem-2615	34	10	cycloaddition	cycloaddition	NOUN
eurjchem-2615	34	11	(	(	PUNCT
eurjchem-2615	34	12	cuaac	cuaac	NOUN
eurjchem-2615	34	13	)	)	PUNCT
eurjchem-2615	34	14	and	and	CCONJ
eurjchem-2615	34	15	(	(	PUNCT
eurjchem-2615	34	16	b	b	NOUN
eurjchem-2615	34	17	)	)	PUNCT
eurjchem-2615	34	18	strain	strain	NOUN
eurjchem-2615	34	19	-	-	PUNCT
eurjchem-2615	34	20	promoted	promote	VERB
eurjchem-2615	34	21	azide	azide	NOUN
eurjchem-2615	34	22	-	-	PUNCT
eurjchem-2615	34	23	alkyne	alkyne	NOUN
eurjchem-2615	34	24	cycloaddition	cycloaddition	NOUN
eurjchem-2615	34	25	(	(	PUNCT
eurjchem-2615	34	26	spaac	spaac	NOUN
eurjchem-2615	34	27	)	)	PUNCT
eurjchem-2615	34	28	reactions	reaction	NOUN
eurjchem-2615	34	29	as	as	ADP
eurjchem-2615	34	30	powerful	powerful	ADJ
eurjchem-2615	34	31	tools	tool	NOUN
eurjchem-2615	34	32	for	for	ADP
eurjchem-2615	34	33	bioorthogonal	bioorthogonal	ADJ
eurjchem-2615	34	34	labeling	labeling	NOUN
eurjchem-2615	34	35	and	and	CCONJ
eurjchem-2615	34	36	efficient	efficient	ADJ
eurjchem-2615	34	37	molecular	molecular	ADJ
eurjchem-2615	34	38	assembly	assembly	NOUN
eurjchem-2615	34	39	.	.	PUNCT
eurjchem-2615	35	1	of	of	ADP
eurjchem-2615	35	2	existing	exist	VERB
eurjchem-2615	35	3	drug	drug	NOUN
eurjchem-2615	35	4	scaffolds	scaffold	NOUN
eurjchem-2615	35	5	and	and	CCONJ
eurjchem-2615	35	6	the	the	DET
eurjchem-2615	35	7	synthesis	synthesis	NOUN
eurjchem-2615	35	8	of	of	ADP
eurjchem-2615	35	9	targeted	target	VERB
eurjchem-2615	35	10	drug	drug	NOUN
eurjchem-2615	35	11	delivery	delivery	NOUN
eurjchem-2615	35	12	systems	system	NOUN
eurjchem-2615	35	13	against	against	ADP
eurjchem-2615	35	14	mycobacterium	mycobacterium	NOUN
eurjchem-2615	35	15	tuberculosis	tuberculosis	NOUN
eurjchem-2615	35	16	.	.	PUNCT
eurjchem-2615	36	1	the	the	DET
eurjchem-2615	36	2	bioorthogonal	bioorthogonal	ADJ
eurjchem-2615	36	3	nature	nature	NOUN
eurjchem-2615	36	4	of	of	ADP
eurjchem-2615	36	5	the	the	DET
eurjchem-2615	36	6	reaction	reaction	NOUN
eurjchem-2615	36	7	,	,	PUNCT
eurjchem-2615	36	8	coupled	couple	VERB
eurjchem-2615	36	9	with	with	ADP
eurjchem-2615	36	10	its	its	PRON
eurjchem-2615	36	11	compatibility	compatibility	NOUN
eurjchem-2615	36	12	with	with	ADP
eurjchem-2615	36	13	physiological	physiological	ADJ
eurjchem-2615	36	14	conditions	condition	NOUN
eurjchem-2615	36	15	,	,	PUNCT
eurjchem-2615	36	16	has	have	AUX
eurjchem-2615	36	17	facilitated	facilitate	VERB
eurjchem-2615	36	18	the	the	DET
eurjchem-2615	36	19	development	development	NOUN
eurjchem-2615	36	20	of	of	ADP
eurjchem-2615	36	21	fluorescent	fluorescent	ADJ
eurjchem-2615	36	22	probes	probe	NOUN
eurjchem-2615	36	23	to	to	PART
eurjchem-2615	36	24	study	study	VERB
eurjchem-2615	36	25	the	the	DET
eurjchem-2615	36	26	components	component	NOUN
eurjchem-2615	36	27	of	of	ADP
eurjchem-2615	36	28	the	the	DET
eurjchem-2615	36	29	mycobacterial	mycobacterial	ADJ
eurjchem-2615	36	30	cell	cell	NOUN
eurjchem-2615	36	31	wall	wall	NOUN
eurjchem-2615	36	32	and	and	CCONJ
eurjchem-2615	36	33	enabled	enable	VERB
eurjchem-2615	36	34	the	the	DET
eurjchem-2615	36	35	strategic	strategic	ADJ
eurjchem-2615	36	36	modification	modification	NOUN
eurjchem-2615	36	37	of	of	ADP
eurjchem-2615	36	38	lead	lead	ADJ
eurjchem-2615	36	39	anti	anti	ADJ
eurjchem-2615	36	40	-	-	ADJ
eurjchem-2615	36	41	tb	tb	ADJ
eurjchem-2615	36	42	compounds	compound	NOUN
eurjchem-2615	36	43	,	,	PUNCT
eurjchem-2615	36	44	including	include	VERB
eurjchem-2615	36	45	the	the	DET
eurjchem-2615	36	46	functionalization	functionalization	NOUN
eurjchem-2615	36	47	of	of	ADP
eurjchem-2615	36	48	the	the	DET
eurjchem-2615	36	49	isoniazid	isoniazid	NOUN
eurjchem-2615	36	50	and	and	CCONJ
eurjchem-2615	36	51	rifampicin	rifampicin	VERB
eurjchem-2615	36	52	derivatives	derivative	NOUN
eurjchem-2615	36	53	.	.	PUNCT
eurjchem-2615	37	1	the	the	DET
eurjchem-2615	37	2	versatility	versatility	NOUN
eurjchem-2615	37	3	of	of	ADP
eurjchem-2615	37	4	click	click	NOUN
eurjchem-2615	37	5	chemistry	chemistry	NOUN
eurjchem-2615	37	6	is	be	AUX
eurjchem-2615	37	7	further	far	ADV
eurjchem-2615	37	8	exemplified	exemplify	VERB
eurjchem-2615	37	9	by	by	ADP
eurjchem-2615	37	10	its	its	PRON
eurjchem-2615	37	11	expanding	expand	VERB
eurjchem-2615	37	12	repertoire	repertoire	NOUN
eurjchem-2615	37	13	,	,	PUNCT
eurjchem-2615	37	14	which	which	PRON
eurjchem-2615	37	15	now	now	ADV
eurjchem-2615	37	16	includes	include	VERB
eurjchem-2615	37	17	strain	strain	NOUN
eurjchem-2615	37	18	-	-	PUNCT
eurjchem-2615	37	19	promoted	promote	VERB
eurjchem-2615	37	20	azide	azide	NOUN
eurjchem-2615	37	21	-	-	PUNCT
eurjchem-2615	37	22	alkyne	alkyne	NOUN
eurjchem-2615	37	23	cycloaddition	cycloaddition	NOUN
eurjchem-2615	37	24	(	(	PUNCT
eurjchem-2615	37	25	spaac	spaac	NOUN
eurjchem-2615	37	26	)	)	PUNCT
eurjchem-2615	37	27	,	,	PUNCT
eurjchem-2615	37	28	thiol	thiol	ADJ
eurjchem-2615	37	29	-	-	PUNCT
eurjchem-2615	37	30	ene	ene	NOUN
eurjchem-2615	37	31	reactions	reaction	NOUN
eurjchem-2615	37	32	,	,	PUNCT
eurjchem-2615	37	33	and	and	CCONJ
eurjchem-2615	37	34	inverse	inverse	NOUN
eurjchem-2615	37	35	electron	electron	NOUN
eurjchem-2615	37	36	-	-	PUNCT
eurjchem-2615	37	37	demand	demand	NOUN
eurjchem-2615	37	38	diels	diel	NOUN
eurjchem-2615	37	39	-	-	PUNCT
eurjchem-2615	37	40	alder	alder	NOUN
eurjchem-2615	37	41	reactions	reaction	NOUN
eurjchem-2615	37	42	,	,	PUNCT
eurjchem-2615	37	43	collectively	collectively	ADV
eurjchem-2615	37	44	providing	provide	VERB
eurjchem-2615	37	45	a	a	DET
eurjchem-2615	37	46	robust	robust	ADJ
eurjchem-2615	37	47	toolkit	toolkit	NOUN
eurjchem-2615	37	48	for	for	ADP
eurjchem-2615	37	49	the	the	DET
eurjchem-2615	37	50	rational	rational	ADJ
eurjchem-2615	37	51	design	design	NOUN
eurjchem-2615	37	52	of	of	ADP
eurjchem-2615	37	53	novel	novel	ADJ
eurjchem-2615	37	54	antitb	antitb	NOUN
eurjchem-2615	37	55	therapeutics	therapeutic	NOUN
eurjchem-2615	37	56	and	and	CCONJ
eurjchem-2615	37	57	diagnostic	diagnostic	ADJ
eurjchem-2615	37	58	tools	tool	NOUN
eurjchem-2615	37	59	,	,	PUNCT
eurjchem-2615	37	60	particularly	particularly	ADV
eurjchem-2615	37	61	significant	significant	ADJ
eurjchem-2615	37	62	in	in	ADP
eurjchem-2615	37	63	addressing	address	VERB
eurjchem-2615	37	64	the	the	DET
eurjchem-2615	37	65	challenges	challenge	NOUN
eurjchem-2615	37	66	posed	pose	VERB
eurjchem-2615	37	67	by	by	ADP
eurjchem-2615	37	68	drug	drug	NOUN
eurjchem-2615	37	69	-	-	PUNCT
eurjchem-2615	37	70	resistant	resistant	ADJ
eurjchem-2615	37	71	tb	tb	ADP
eurjchem-2615	37	72	strains	strain	NOUN
eurjchem-2615	37	73	[	[	PUNCT
eurjchem-2615	37	74	21	21	NUM
eurjchem-2615	37	75	-	-	SYM
eurjchem-2615	37	76	24	24	NUM
eurjchem-2615	37	77	]	]	PUNCT
eurjchem-2615	37	78	.	.	PUNCT
eurjchem-2615	38	1	this	this	DET
eurjchem-2615	38	2	review	review	NOUN
eurjchem-2615	38	3	examines	examine	VERB
eurjchem-2615	38	4	the	the	DET
eurjchem-2615	38	5	transformative	transformative	ADJ
eurjchem-2615	38	6	role	role	NOUN
eurjchem-2615	38	7	of	of	ADP
eurjchem-2615	38	8	click	click	VERB
eurjchem-2615	38	9	chemistry	chemistry	NOUN
eurjchem-2615	38	10	in	in	ADP
eurjchem-2615	38	11	tuberculosis	tuberculosis	NOUN
eurjchem-2615	38	12	research	research	NOUN
eurjchem-2615	38	13	,	,	PUNCT
eurjchem-2615	38	14	focusing	focus	VERB
eurjchem-2615	38	15	on	on	ADP
eurjchem-2615	38	16	its	its	PRON
eurjchem-2615	38	17	use	use	NOUN
eurjchem-2615	38	18	in	in	ADP
eurjchem-2615	38	19	drug	drug	NOUN
eurjchem-2615	38	20	discovery	discovery	NOUN
eurjchem-2615	38	21	over	over	ADP
eurjchem-2615	38	22	the	the	DET
eurjchem-2615	38	23	past	past	ADJ
eurjchem-2615	38	24	decade	decade	NOUN
eurjchem-2615	38	25	.	.	PUNCT
eurjchem-2615	39	1	we	we	PRON
eurjchem-2615	39	2	critically	critically	ADV
eurjchem-2615	39	3	analyze	analyze	VERB
eurjchem-2615	39	4	how	how	SCONJ
eurjchem-2615	39	5	click	click	VERB
eurjchem-2615	39	6	chemistry	chemistry	NOUN
eurjchem-2615	39	7	methodologies	methodology	NOUN
eurjchem-2615	39	8	have	have	AUX
eurjchem-2615	39	9	advanced	advance	VERB
eurjchem-2615	39	10	our	our	PRON
eurjchem-2615	39	11	understanding	understanding	NOUN
eurjchem-2615	39	12	of	of	ADP
eurjchem-2615	39	13	tb	tb	ADP
eurjchem-2615	39	14	pathogenesis	pathogenesis	NOUN
eurjchem-2615	39	15	and	and	CCONJ
eurjchem-2615	39	16	contributed	contribute	VERB
eurjchem-2615	39	17	to	to	ADP
eurjchem-2615	39	18	the	the	DET
eurjchem-2615	39	19	development	development	NOUN
eurjchem-2615	39	20	of	of	ADP
eurjchem-2615	39	21	novel	novel	ADJ
eurjchem-2615	39	22	therapeutic	therapeutic	ADJ
eurjchem-2615	39	23	strategies	strategy	NOUN
eurjchem-2615	39	24	against	against	ADP
eurjchem-2615	39	25	drug	drug	NOUN
eurjchem-2615	39	26	-	-	PUNCT
eurjchem-2615	39	27	resistant	resistant	ADJ
eurjchem-2615	39	28	mycobacterium	mycobacterium	NOUN
eurjchem-2615	39	29	tuberculosis	tuberculosis	NOUN
eurjchem-2615	39	30	strains	strain	NOUN
eurjchem-2615	39	31	.	.	PUNCT
eurjchem-2615	40	1	special	special	ADJ
eurjchem-2615	40	2	emphasis	emphasis	NOUN
eurjchem-2615	40	3	is	be	AUX
eurjchem-2615	40	4	placed	place	VERB
eurjchem-2615	40	5	on	on	ADP
eurjchem-2615	40	6	copper(i)catalyzed	copper(i)catalyze	VERB
eurjchem-2615	40	7	azide	azide	NOUN
eurjchem-2615	40	8	-	-	PUNCT
eurjchem-2615	40	9	alkyne	alkyne	NOUN
eurjchem-2615	40	10	cycloaddition	cycloaddition	NOUN
eurjchem-2615	40	11	reactions	reaction	NOUN
eurjchem-2615	40	12	in	in	ADP
eurjchem-2615	40	13	anti	anti	ADJ
eurjchem-2615	40	14	-	-	ADJ
eurjchem-2615	40	15	tb	tb	ADJ
eurjchem-2615	40	16	drug	drug	NOUN
eurjchem-2615	40	17	development	development	NOUN
eurjchem-2615	40	18	,	,	PUNCT
eurjchem-2615	40	19	biomarker	biomarker	NOUN
eurjchem-2615	40	20	detection	detection	NOUN
eurjchem-2615	40	21	,	,	PUNCT
eurjchem-2615	40	22	and	and	CCONJ
eurjchem-2615	40	23	the	the	DET
eurjchem-2615	40	24	modification	modification	NOUN
eurjchem-2615	40	25	of	of	ADP
eurjchem-2615	40	26	existing	exist	VERB
eurjchem-2615	40	27	drug	drug	NOUN
eurjchem-2615	40	28	scaffolds	scaffold	NOUN
eurjchem-2615	40	29	.	.	PUNCT
eurjchem-2615	41	1	furthermore	furthermore	ADV
eurjchem-2615	41	2	,	,	PUNCT
eurjchem-2615	41	3	this	this	DET
eurjchem-2615	41	4	review	review	NOUN
eurjchem-2615	41	5	evaluates	evaluate	VERB
eurjchem-2615	41	6	emerging	emerge	VERB
eurjchem-2615	41	7	click	click	NOUN
eurjchem-2615	41	8	chemistry	chemistry	NOUN
eurjchem-2615	41	9	approaches	approach	NOUN
eurjchem-2615	41	10	that	that	PRON
eurjchem-2615	41	11	show	show	VERB
eurjchem-2615	41	12	promise	promise	NOUN
eurjchem-2615	41	13	in	in	ADP
eurjchem-2615	41	14	addressing	address	VERB
eurjchem-2615	41	15	current	current	ADJ
eurjchem-2615	41	16	challenges	challenge	NOUN
eurjchem-2615	41	17	in	in	ADP
eurjchem-2615	41	18	tb	tb	ADP
eurjchem-2615	41	19	treatment	treatment	NOUN
eurjchem-2615	41	20	and	and	CCONJ
eurjchem-2615	41	21	diagnosis	diagnosis	NOUN
eurjchem-2615	41	22	,	,	PUNCT
eurjchem-2615	41	23	providing	provide	VERB
eurjchem-2615	41	24	insight	insight	NOUN
eurjchem-2615	41	25	into	into	ADP
eurjchem-2615	41	26	future	future	ADJ
eurjchem-2615	41	27	directions	direction	NOUN
eurjchem-2615	41	28	for	for	ADP
eurjchem-2615	41	29	combating	combat	VERB
eurjchem-2615	41	30	this	this	DET
eurjchem-2615	41	31	persistent	persistent	ADJ
eurjchem-2615	41	32	global	global	ADJ
eurjchem-2615	41	33	health	health	NOUN
eurjchem-2615	41	34	threat	threat	NOUN
eurjchem-2615	41	35	.	.	PUNCT
eurjchem-2615	42	1	2	2	X
eurjchem-2615	42	2	.	.	X
eurjchem-2615	42	3	fundamentals	fundamental	NOUN
eurjchem-2615	42	4	of	of	ADP
eurjchem-2615	42	5	click	click	VERB
eurjchem-2615	42	6	chemistry	chemistry	NOUN
eurjchem-2615	42	7	in	in	ADP
eurjchem-2615	42	8	tb	tb	ADP
eurjchem-2615	42	9	research	research	NOUN
eurjchem-2615	42	10	2.1	2.1	NUM
eurjchem-2615	42	11	.	.	PUNCT
eurjchem-2615	42	12	conventional	conventional	ADJ
eurjchem-2615	42	13	tb	tb	X
eurjchem-2615	42	14	drug	drug	NOUN
eurjchem-2615	42	15	modification	modification	NOUN
eurjchem-2615	42	16	approaches	approach	NOUN
eurjchem-2615	42	17	face	face	VERB
eurjchem-2615	42	18	critical	critical	ADJ
eurjchem-2615	42	19	limitations	limitation	NOUN
eurjchem-2615	42	20	isoniazid	isoniazid	NOUN
eurjchem-2615	42	21	,	,	PUNCT
eurjchem-2615	42	22	the	the	DET
eurjchem-2615	42	23	most	most	ADV
eurjchem-2615	42	24	widely	widely	ADV
eurjchem-2615	42	25	prescribed	prescribe	VERB
eurjchem-2615	42	26	antituberculosis	antituberculosis	NOUN
eurjchem-2615	42	27	agent	agent	NOUN
eurjchem-2615	43	1	[	[	X
eurjchem-2615	43	2	23,25	23,25	NOUN
eurjchem-2615	43	3	]	]	PUNCT
eurjchem-2615	43	4	,	,	PUNCT
eurjchem-2615	43	5	requires	require	VERB
eurjchem-2615	43	6	katg	katg	PROPN
eurjchem-2615	43	7	-	-	PUNCT
eurjchem-2615	43	8	encoded	encode	VERB
eurjchem-2615	43	9	catalase	catalase	NOUN
eurjchem-2615	43	10	-	-	PUNCT
eurjchem-2615	43	11	peroxidase	peroxidase	NOUN
eurjchem-2615	43	12	activation	activation	NOUN
eurjchem-2615	43	13	to	to	PART
eurjchem-2615	43	14	form	form	VERB
eurjchem-2615	43	15	the	the	DET
eurjchem-2615	43	16	inhibitory	inhibitory	ADJ
eurjchem-2615	43	17	inh	inh	PROPN
eurjchem-2615	43	18	-	-	PUNCT
eurjchem-2615	43	19	nad	nad	PROPN
eurjchem-2615	43	20	adduct	adduct	NOUN
eurjchem-2615	43	21	,	,	PUNCT
eurjchem-2615	43	22	where	where	SCONJ
eurjchem-2615	43	23	specific	specific	ADJ
eurjchem-2615	43	24	molecular	molecular	ADJ
eurjchem-2615	43	25	geometry	geometry	NOUN
eurjchem-2615	43	26	and	and	CCONJ
eurjchem-2615	43	27	hydrogen	hydrogen	NOUN
eurjchem-2615	43	28	bonding	bonding	NOUN
eurjchem-2615	43	29	networks	network	NOUN
eurjchem-2615	43	30	are	be	AUX
eurjchem-2615	43	31	[	[	X
eurjchem-2615	43	32	16	16	NUM
eurjchem-2615	43	33	]	]	X
eurjchem-2615	43	34	synthetic	synthetic	ADJ
eurjchem-2615	43	35	methodologies	methodology	NOUN
eurjchem-2615	43	36	struggling	struggle	VERB
eurjchem-2615	43	37	to	to	PART
eurjchem-2615	43	38	maintain	maintain	VERB
eurjchem-2615	43	39	critical	critical	ADJ
eurjchem-2615	43	40	hydrogen	hydrogen	NOUN
eurjchem-2615	43	41	bonding	bonding	NOUN
eurjchem-2615	43	42	networks	network	NOUN
eurjchem-2615	43	43	while	while	SCONJ
eurjchem-2615	43	44	introducing	introduce	VERB
eurjchem-2615	43	45	novel	novel	ADJ
eurjchem-2615	43	46	functional	functional	ADJ
eurjchem-2615	43	47	groups	group	NOUN
eurjchem-2615	43	48	,	,	PUNCT
eurjchem-2615	43	49	given	give	VERB
eurjchem-2615	43	50	the	the	DET
eurjchem-2615	43	51	spatial	spatial	ADJ
eurjchem-2615	43	52	constraints	constraint	NOUN
eurjchem-2615	43	53	inherent	inherent	ADJ
eurjchem-2615	43	54	in	in	ADP
eurjchem-2615	43	55	the	the	DET
eurjchem-2615	43	56	mechanism	mechanism	NOUN
eurjchem-2615	43	57	of	of	ADP
eurjchem-2615	43	58	action	action	NOUN
eurjchem-2615	43	59	of	of	ADP
eurjchem-2615	43	60	the	the	DET
eurjchem-2615	43	61	drug	drug	NOUN
eurjchem-2615	43	62	and	and	CCONJ
eurjchem-2615	43	63	the	the	DET
eurjchem-2615	43	64	target	target	NOUN
eurjchem-2615	43	65	interaction	interaction	NOUN
eurjchem-2615	44	1	[	[	X
eurjchem-2615	44	2	26	26	NUM
eurjchem-2615	44	3	]	]	PUNCT
eurjchem-2615	44	4	.	.	PUNCT
eurjchem-2615	45	1	rifampicin	rifampicin	VERB
eurjchem-2615	45	2	exhibits	exhibit	VERB
eurjchem-2615	45	3	significant	significant	ADJ
eurjchem-2615	45	4	ph	ph	ADJ
eurjchem-2615	45	5	-	-	ADJ
eurjchem-2615	45	6	dependent	dependent	ADJ
eurjchem-2615	45	7	stability	stability	NOUN
eurjchem-2615	45	8	characteristics	characteristic	NOUN
eurjchem-2615	45	9	,	,	PUNCT
eurjchem-2615	45	10	demonstrating	demonstrate	VERB
eurjchem-2615	45	11	complex	complex	ADJ
eurjchem-2615	45	12	degradation	degradation	NOUN
eurjchem-2615	45	13	kinetics	kinetic	NOUN
eurjchem-2615	45	14	across	across	ADP
eurjchem-2615	45	15	physiologically	physiologically	ADV
eurjchem-2615	45	16	relevant	relevant	ADJ
eurjchem-2615	45	17	ph	ph	ADJ
eurjchem-2615	45	18	ranges	range	NOUN
eurjchem-2615	45	19	.	.	PUNCT
eurjchem-2615	46	1	studies	study	NOUN
eurjchem-2615	46	2	utilizing	utilize	VERB
eurjchem-2615	46	3	hplc	hplc	PROPN
eurjchem-2615	46	4	-	-	PUNCT
eurjchem-2615	46	5	ms	ms	PROPN
eurjchem-2615	46	6	/	/	SYM
eurjchem-2615	46	7	ms	ms	NOUN
eurjchem-2615	46	8	analysis	analysis	NOUN
eurjchem-2615	46	9	reveal	reveal	VERB
eurjchem-2615	46	10	that	that	SCONJ
eurjchem-2615	46	11	rifampicin	rifampicin	VERB
eurjchem-2615	46	12	undergoes	undergo	VERB
eurjchem-2615	46	13	rapid	rapid	ADJ
eurjchem-2615	46	14	degradation	degradation	NOUN
eurjchem-2615	46	15	under	under	ADP
eurjchem-2615	46	16	strongly	strongly	ADV
eurjchem-2615	46	17	acidic	acidic	ADJ
eurjchem-2615	46	18	conditions	condition	NOUN
eurjchem-2615	46	19	(	(	PUNCT
eurjchem-2615	46	20	ph	ph	NOUN
eurjchem-2615	46	21	=	=	NOUN
eurjchem-2615	46	22	1.2	1.2	NUM
eurjchem-2615	46	23	)	)	PUNCT
eurjchem-2615	46	24	,	,	PUNCT
eurjchem-2615	46	25	primarily	primarily	ADV
eurjchem-2615	46	26	through	through	ADP
eurjchem-2615	46	27	hydrolytic	hydrolytic	ADJ
eurjchem-2615	46	28	cleavage	cleavage	NOUN
eurjchem-2615	46	29	that	that	PRON
eurjchem-2615	46	30	leads	lead	VERB
eurjchem-2615	46	31	to	to	ADP
eurjchem-2615	46	32	the	the	DET
eurjchem-2615	46	33	formation	formation	NOUN
eurjchem-2615	46	34	of	of	ADP
eurjchem-2615	46	35	3	3	NUM
eurjchem-2615	46	36	-	-	PUNCT
eurjchem-2615	46	37	formyl	formyl	ADJ
eurjchem-2615	46	38	rifamycin	rifamycin	NOUN
eurjchem-2615	46	39	sv	sv	INTJ
eurjchem-2615	46	40	as	as	ADP
eurjchem-2615	46	41	the	the	DET
eurjchem-2615	46	42	predominant	predominant	ADJ
eurjchem-2615	46	43	degradation	degradation	NOUN
eurjchem-2615	46	44	product	product	NOUN
eurjchem-2615	46	45	.	.	PUNCT
eurjchem-2615	47	1	the	the	DET
eurjchem-2615	47	2	stability	stability	NOUN
eurjchem-2615	47	3	profile	profile	NOUN
eurjchem-2615	47	4	shows	show	VERB
eurjchem-2615	47	5	marked	mark	VERB
eurjchem-2615	47	6	improvement	improvement	NOUN
eurjchem-2615	47	7	at	at	ADP
eurjchem-2615	47	8	ph	ph	NOUN
eurjchem-2615	47	9	=	=	SYM
eurjchem-2615	47	10	4.5	4.5	NUM
eurjchem-2615	47	11	,	,	PUNCT
eurjchem-2615	47	12	with	with	ADP
eurjchem-2615	47	13	optimal	optimal	ADJ
eurjchem-2615	47	14	stability	stability	NOUN
eurjchem-2615	47	15	observed	observe	VERB
eurjchem-2615	47	16	at	at	ADP
eurjchem-2615	47	17	ph	ph	NOUN
eurjchem-2615	47	18	=	=	SYM
eurjchem-2615	47	19	6.8	6.8	NUM
eurjchem-2615	47	20	,	,	PUNCT
eurjchem-2615	47	21	while	while	SCONJ
eurjchem-2615	47	22	slightly	slightly	ADV
eurjchem-2615	47	23	alkaline	alkaline	NOUN
eurjchem-2615	47	24	conditions	condition	NOUN
eurjchem-2615	47	25	(	(	PUNCT
eurjchem-2615	47	26	ph	ph	NOUN
eurjchem-2615	47	27	=	=	NOUN
eurjchem-2615	47	28	7.4	7.4	NUM
eurjchem-2615	47	29	)	)	PUNCT
eurjchem-2615	47	30	initiate	initiate	VERB
eurjchem-2615	47	31	a	a	DET
eurjchem-2615	47	32	secondary	secondary	ADJ
eurjchem-2615	47	33	degradation	degradation	NOUN
eurjchem-2615	47	34	pathway	pathway	NOUN
eurjchem-2615	47	35	.	.	PUNCT
eurjchem-2615	48	1	this	this	DET
eurjchem-2615	48	2	ph	ph	VERB
eurjchem-2615	48	3	-	-	ADJ
eurjchem-2615	48	4	dependent	dependent	ADJ
eurjchem-2615	48	5	degradation	degradation	NOUN
eurjchem-2615	48	6	pattern	pattern	NOUN
eurjchem-2615	48	7	significantly	significantly	ADV
eurjchem-2615	48	8	influences	influence	VERB
eurjchem-2615	48	9	both	both	PRON
eurjchem-2615	48	10	pharmaceutical	pharmaceutical	ADJ
eurjchem-2615	48	11	formulation	formulation	NOUN
eurjchem-2615	48	12	strategies	strategy	NOUN
eurjchem-2615	48	13	and	and	CCONJ
eurjchem-2615	48	14	drug	drug	NOUN
eurjchem-2615	48	15	bioavailability	bioavailability	NOUN
eurjchem-2615	48	16	profile	profile	NOUN
eurjchem-2615	48	17	,	,	PUNCT
eurjchem-2615	48	18	necessitating	necessitate	VERB
eurjchem-2615	48	19	careful	careful	ADJ
eurjchem-2615	48	20	consideration	consideration	NOUN
eurjchem-2615	48	21	in	in	ADP
eurjchem-2615	48	22	drug	drug	NOUN
eurjchem-2615	48	23	delivery	delivery	NOUN
eurjchem-2615	48	24	system	system	NOUN
eurjchem-2615	48	25	design	design	NOUN
eurjchem-2615	48	26	and	and	CCONJ
eurjchem-2615	48	27	stability	stability	NOUN
eurjchem-2615	48	28	optimization	optimization	NOUN
eurjchem-2615	48	29	protocols	protocol	NOUN
eurjchem-2615	48	30	[	[	X
eurjchem-2615	48	31	27	27	NUM
eurjchem-2615	48	32	]	]	PUNCT
eurjchem-2615	48	33	.	.	PUNCT
eurjchem-2615	49	1	the	the	DET
eurjchem-2615	49	2	pronounced	pronounce	VERB
eurjchem-2615	49	3	thermal	thermal	ADJ
eurjchem-2615	49	4	sensitivity	sensitivity	NOUN
eurjchem-2615	49	5	of	of	ADP
eurjchem-2615	49	6	rifampicin	rifampicin	VERB
eurjchem-2615	49	7	presents	present	VERB
eurjchem-2615	49	8	significant	significant	ADJ
eurjchem-2615	49	9	constraints	constraint	NOUN
eurjchem-2615	49	10	for	for	ADP
eurjchem-2615	49	11	chemical	chemical	NOUN
eurjchem-2615	49	12	modification	modification	NOUN
eurjchem-2615	49	13	strategies	strategy	NOUN
eurjchem-2615	49	14	.	.	PUNCT
eurjchem-2615	50	1	the	the	DET
eurjchem-2615	50	2	drug	drug	NOUN
eurjchem-2615	50	3	exhibits	exhibit	VERB
eurjchem-2615	50	4	critical	critical	ADJ
eurjchem-2615	50	5	instability	instability	NOUN
eurjchem-2615	50	6	at	at	ADP
eurjchem-2615	50	7	temperatures	temperature	NOUN
eurjchem-2615	50	8	above	above	ADP
eurjchem-2615	50	9	40	40	NUM
eurjchem-2615	50	10	°	°	NOUN
eurjchem-2615	50	11	c	c	NOUN
eurjchem-2615	50	12	,	,	PUNCT
eurjchem-2615	50	13	undergoing	undergo	VERB
eurjchem-2615	50	14	oxidative	oxidative	ADJ
eurjchem-2615	50	15	degradation	degradation	NOUN
eurjchem-2615	50	16	that	that	PRON
eurjchem-2615	50	17	predominantly	predominantly	ADV
eurjchem-2615	50	18	produces	produce	VERB
eurjchem-2615	50	19	rifampicin	rifampicin	VERB
eurjchem-2615	50	20	quinone	quinone	NOUN
eurjchem-2615	50	21	,	,	PUNCT
eurjchem-2615	50	22	following	follow	VERB
eurjchem-2615	50	23	the	the	DET
eurjchem-2615	50	24	first	first	ADJ
eurjchem-2615	50	25	-	-	PUNCT
eurjchem-2615	50	26	order	order	NOUN
eurjchem-2615	50	27	degradation	degradation	NOUN
eurjchem-2615	50	28	kinetics	kinetic	NOUN
eurjchem-2615	50	29	[	[	X
eurjchem-2615	50	30	28	28	NUM
eurjchem-2615	50	31	]	]	PUNCT
eurjchem-2615	50	32	.	.	PUNCT
eurjchem-2615	51	1	this	this	DET
eurjchem-2615	51	2	thermal	thermal	ADJ
eurjchem-2615	51	3	liability	liability	NOUN
eurjchem-2615	51	4	poses	pose	VERB
eurjchem-2615	51	5	substantial	substantial	ADJ
eurjchem-2615	51	6	challenges	challenge	NOUN
eurjchem-2615	51	7	for	for	ADP
eurjchem-2615	51	8	conventional	conventional	ADJ
eurjchem-2615	51	9	synthetic	synthetic	ADJ
eurjchem-2615	51	10	methodologies	methodology	NOUN
eurjchem-2615	51	11	,	,	PUNCT
eurjchem-2615	51	12	which	which	PRON
eurjchem-2615	51	13	often	often	ADV
eurjchem-2615	51	14	require	require	VERB
eurjchem-2615	51	15	elevated	elevated	ADJ
eurjchem-2615	51	16	temperatures	temperature	NOUN
eurjchem-2615	51	17	for	for	ADP
eurjchem-2615	51	18	efficient	efficient	ADJ
eurjchem-2615	51	19	reactivity	reactivity	NOUN
eurjchem-2615	51	20	[	[	X
eurjchem-2615	51	21	28	28	NUM
eurjchem-2615	51	22	]	]	PUNCT
eurjchem-2615	51	23	.	.	PUNCT
eurjchem-2615	52	1	2.2	2.2	NUM
eurjchem-2615	52	2	.	.	PUNCT
eurjchem-2615	52	3	click	click	VERB
eurjchem-2615	52	4	chemistry	chemistry	NOUN
eurjchem-2615	52	5	’s	’s	PART
eurjchem-2615	52	6	unique	unique	ADJ
eurjchem-2615	52	7	synthetic	synthetic	ADJ
eurjchem-2615	52	8	advantages	advantage	NOUN
eurjchem-2615	52	9	in	in	ADP
eurjchem-2615	52	10	tb	tb	ADP
eurjchem-2615	52	11	drug	drug	NOUN
eurjchem-2615	52	12	development	development	NOUN
eurjchem-2615	52	13	2.2.1	2.2.1	NUM
eurjchem-2615	52	14	.	.	PUNCT
eurjchem-2615	53	1	mechanistic	mechanistic	ADJ
eurjchem-2615	53	2	insights	insight	NOUN
eurjchem-2615	53	3	into	into	AUX
eurjchem-2615	53	4	click	click	VERB
eurjchem-2615	53	5	chemistry	chemistry	NOUN
eurjchem-2615	53	6	click	click	VERB
eurjchem-2615	53	7	chemistry	chemistry	NOUN
eurjchem-2615	53	8	in	in	ADP
eurjchem-2615	53	9	the	the	DET
eurjchem-2615	53	10	development	development	NOUN
eurjchem-2615	53	11	of	of	ADP
eurjchem-2615	53	12	tb	tb	ADP
eurjchem-2615	53	13	drugs	drug	NOUN
eurjchem-2615	53	14	uses	use	VERB
eurjchem-2615	53	15	primarily	primarily	ADV
eurjchem-2615	53	16	two	two	NUM
eurjchem-2615	53	17	fundamental	fundamental	ADJ
eurjchem-2615	53	18	cycloaddition	cycloaddition	NOUN
eurjchem-2615	53	19	approaches	approach	NOUN
eurjchem-2615	53	20	(	(	PUNCT
eurjchem-2615	53	21	figure	figure	NOUN
eurjchem-2615	53	22	1	1	NUM
eurjchem-2615	53	23	)	)	PUNCT
eurjchem-2615	53	24	.	.	PUNCT
eurjchem-2615	54	1	copper	copper	NOUN
eurjchem-2615	54	2	-	-	PUNCT
eurjchem-2615	54	3	catalyzed	catalyze	VERB
eurjchem-2615	54	4	azide	azide	NOUN
eurjchem-2615	54	5	-	-	PUNCT
eurjchem-2615	54	6	alkyne	alkyne	NOUN
eurjchem-2615	54	7	cycloaddition	cycloaddition	NOUN
eurjchem-2615	54	8	(	(	PUNCT
eurjchem-2615	54	9	cuaac	cuaac	NOUN
eurjchem-2615	54	10	)	)	PUNCT
eurjchem-2615	54	11	and	and	CCONJ
eurjchem-2615	54	12	strain	strain	NOUN
eurjchem-2615	54	13	-	-	PUNCT
eurjchem-2615	54	14	promoted	promote	VERB
eurjchem-2615	54	15	azide	azide	NOUN
eurjchem-2615	54	16	-	-	PUNCT
eurjchem-2615	54	17	alkyne	alkyne	NOUN
eurjchem-2615	54	18	cycloaddition	cycloaddition	NOUN
eurjchem-2615	54	19	(	(	PUNCT
eurjchem-2615	54	20	spaac	spaac	NOUN
eurjchem-2615	54	21	)	)	PUNCT
eurjchem-2615	54	22	.	.	PUNCT
eurjchem-2615	55	1	the	the	DET
eurjchem-2615	55	2	copper(i)-catalyzed	copper(i)-catalyze	VERB
eurjchem-2615	55	3	azide	azide	NOUN
eurjchem-2615	55	4	-	-	PUNCT
eurjchem-2615	55	5	alkyne	alkyne	NOUN
eurjchem-2615	55	6	cycloaddition	cycloaddition	NOUN
eurjchem-2615	55	7	(	(	PUNCT
eurjchem-2615	55	8	cuaac	cuaac	NOUN
eurjchem-2615	55	9	)	)	PUNCT
eurjchem-2615	55	10	reaction	reaction	NOUN
eurjchem-2615	55	11	,	,	PUNCT
eurjchem-2615	55	12	representing	represent	VERB
eurjchem-2615	55	13	the	the	DET
eurjchem-2615	55	14	cornerstone	cornerstone	NOUN
eurjchem-2615	55	15	of	of	ADP
eurjchem-2615	55	16	click	click	VERB
eurjchem-2615	55	17	chemistry	chemistry	NOUN
eurjchem-2615	55	18	applications	application	NOUN
eurjchem-2615	55	19	in	in	ADP
eurjchem-2615	55	20	tb	tb	ADP
eurjchem-2615	55	21	research	research	NOUN
eurjchem-2615	55	22	,	,	PUNCT
eurjchem-2615	55	23	demonstrates	demonstrate	VERB
eurjchem-2615	55	24	remarkable	remarkable	ADJ
eurjchem-2615	55	25	efficacy	efficacy	NOUN
eurjchem-2615	55	26	under	under	ADP
eurjchem-2615	55	27	physiological	physiological	ADJ
eurjchem-2615	55	28	conditions	condition	NOUN
eurjchem-2615	55	29	,	,	PUNCT
eurjchem-2615	55	30	enabling	enable	VERB
eurjchem-2615	55	31	precise	precise	ADJ
eurjchem-2615	55	32	molecular	molecular	ADJ
eurjchem-2615	55	33	modifications	modification	NOUN
eurjchem-2615	55	34	of	of	ADP
eurjchem-2615	55	35	antitubercular	antitubercular	ADJ
eurjchem-2615	55	36	compounds	compound	NOUN
eurjchem-2615	55	37	.	.	PUNCT
eurjchem-2615	56	1	this	this	DET
eurjchem-2615	56	2	reaction	reaction	NOUN
eurjchem-2615	56	3	proceeds	proceed	VERB
eurjchem-2615	56	4	through	through	ADP
eurjchem-2615	56	5	a	a	DET
eurjchem-2615	56	6	stepwise	stepwise	ADJ
eurjchem-2615	56	7	mechanism	mechanism	NOUN
eurjchem-2615	56	8	involving	involve	VERB
eurjchem-2615	56	9	the	the	DET
eurjchem-2615	56	10	formation	formation	NOUN
eurjchem-2615	56	11	of	of	ADP
eurjchem-2615	56	12	copper(i	copper(i	NOUN
eurjchem-2615	56	13	)	)	PUNCT
eurjchem-2615	56	14	acetylide	acetylide	ADV
eurjchem-2615	56	15	,	,	PUNCT
eurjchem-2615	56	16	followed	follow	VERB
eurjchem-2615	56	17	by	by	ADP
eurjchem-2615	56	18	azide	azide	NOUN
eurjchem-2615	56	19	coordination	coordination	NOUN
eurjchem-2615	56	20	and	and	CCONJ
eurjchem-2615	56	21	metallocycle	metallocycle	NOUN
eurjchem-2615	56	22	formation	formation	NOUN
eurjchem-2615	56	23	,	,	PUNCT
eurjchem-2615	56	24	which	which	PRON
eurjchem-2615	56	25	ultimately	ultimately	ADV
eurjchem-2615	56	26	produces	produce	VERB
eurjchem-2615	56	27	1,2,3	1,2,3	NUM
eurjchem-2615	56	28	-	-	NOUN
eurjchem-2615	56	29	triazole	triazole	NOUN
eurjchem-2615	56	30	and	and	CCONJ
eurjchem-2615	56	31	1,2,4	1,2,4	NUM
eurjchem-2615	56	32	-	-	PUNCT
eurjchem-2615	56	33	triazole	triazole	NOUN
eurjchem-2615	56	34	products	product	NOUN
eurjchem-2615	56	35	with	with	ADP
eurjchem-2615	56	36	exceptional	exceptional	ADJ
eurjchem-2615	56	37	regioselectivity	regioselectivity	NOUN
eurjchem-2615	56	38	[	[	X
eurjchem-2615	56	39	29	29	NUM
eurjchem-2615	56	40	]	]	PUNCT
eurjchem-2615	56	41	(	(	PUNCT
eurjchem-2615	56	42	figure	figure	NOUN
eurjchem-2615	56	43	2	2	NUM
eurjchem-2615	56	44	)	)	PUNCT
eurjchem-2615	56	45	.	.	PUNCT
eurjchem-2615	57	1	the	the	DET
eurjchem-2615	57	2	catalytic	catalytic	ADJ
eurjchem-2615	57	3	system	system	NOUN
eurjchem-2615	57	4	,	,	PUNCT
eurjchem-2615	57	5	typically	typically	ADV
eurjchem-2615	57	6	employing	employ	VERB
eurjchem-2615	57	7	cuso4	cuso4	NOUN
eurjchem-2615	57	8	/	/	SYM
eurjchem-2615	57	9	sodium	sodium	NOUN
eurjchem-2615	57	10	ascorbate	ascorbate	NOUN
eurjchem-2615	57	11	or	or	CCONJ
eurjchem-2615	57	12	cu(i	cu(i	NOUN
eurjchem-2615	57	13	)	)	PUNCT
eurjchem-2615	57	14	salts	salt	NOUN
eurjchem-2615	57	15	with	with	ADP
eurjchem-2615	57	16	specialized	specialized	ADJ
eurjchem-2615	57	17	ligands	ligand	NOUN
eurjchem-2615	57	18	such	such	ADJ
eurjchem-2615	57	19	as	as	ADP
eurjchem-2615	57	20	tbta	tbta	NOUN
eurjchem-2615	57	21	,	,	PUNCT
eurjchem-2615	57	22	ensures	ensure	VERB
eurjchem-2615	57	23	rapid	rapid	ADJ
eurjchem-2615	57	24	reaction	reaction	NOUN
eurjchem-2615	57	25	kinetics	kinetic	NOUN
eurjchem-2615	57	26	while	while	SCONJ
eurjchem-2615	57	27	maintaining	maintain	VERB
eurjchem-2615	57	28	biocompatibility	biocompatibility	NOUN
eurjchem-2615	57	29	[	[	X
eurjchem-2615	57	30	30	30	NUM
eurjchem-2615	57	31	]	]	PUNCT
eurjchem-2615	57	32	.	.	PUNCT
eurjchem-2615	58	1	2.2.2	2.2.2	X
eurjchem-2615	58	2	.	.	PUNCT
eurjchem-2615	59	1	click	click	VERB
eurjchem-2615	59	2	chemistry	chemistry	NOUN
eurjchem-2615	59	3	from	from	ADP
eurjchem-2615	59	4	structural	structural	ADJ
eurjchem-2615	59	5	modification	modification	NOUN
eurjchem-2615	59	6	to	to	ADP
eurjchem-2615	59	7	biological	biological	ADJ
eurjchem-2615	59	8	applications	application	NOUN
eurjchem-2615	59	9	structural	structural	ADJ
eurjchem-2615	59	10	modification	modification	NOUN
eurjchem-2615	59	11	of	of	ADP
eurjchem-2615	59	12	existing	exist	VERB
eurjchem-2615	59	13	tb	tb	ADP
eurjchem-2615	59	14	drugs	drug	NOUN
eurjchem-2615	59	15	,	,	PUNCT
eurjchem-2615	59	16	particularly	particularly	ADV
eurjchem-2615	59	17	isoniazid	isoniazid	NOUN
eurjchem-2615	59	18	and	and	CCONJ
eurjchem-2615	59	19	ethambutol	ethambutol	ADJ
eurjchem-2615	59	20	,	,	PUNCT
eurjchem-2615	59	21	where	where	SCONJ
eurjchem-2615	59	22	cuaac	cuaac	NOUN
eurjchem-2615	59	23	enables	enable	VERB
eurjchem-2615	59	24	the	the	DET
eurjchem-2615	59	25	precise	precise	ADJ
eurjchem-2615	59	26	integration	integration	NOUN
eurjchem-2615	59	27	of	of	ADP
eurjchem-2615	59	28	triazole	triazole	ADJ
eurjchem-2615	59	29	linkers	linker	NOUN
eurjchem-2615	59	30	.	.	PUNCT
eurjchem-2615	60	1	these	these	DET
eurjchem-2615	60	2	modifications	modification	NOUN
eurjchem-2615	60	3	serve	serve	VERB
eurjchem-2615	60	4	two	two	NUM
eurjchem-2615	60	5	purposes	purpose	NOUN
eurjchem-2615	60	6	:	:	PUNCT
eurjchem-2615	60	7	enhancing	enhance	VERB
eurjchem-2615	60	8	lipophilicity	lipophilicity	NOUN
eurjchem-2615	60	9	to	to	PART
eurjchem-2615	60	10	improve	improve	VERB
eurjchem-2615	60	11	mycobacterial	mycobacterial	ADJ
eurjchem-2615	60	12	cell	cell	NOUN
eurjchem-2615	60	13	wall	wall	NOUN
eurjchem-2615	60	14	penetration	penetration	NOUN
eurjchem-2615	60	15	and	and	CCONJ
eurjchem-2615	60	16	to	to	PART
eurjchem-2615	60	17	provide	provide	VERB
eurjchem-2615	60	18	new	new	ADJ
eurjchem-2615	60	19	pharmacophoric	pharmacophoric	ADJ
eurjchem-2615	60	20	elements	element	NOUN
eurjchem-2615	60	21	that	that	PRON
eurjchem-2615	60	22	often	often	ADV
eurjchem-2615	60	23	strengthen	strengthen	VERB
eurjchem-2615	60	24	binding	bind	VERB
eurjchem-2615	60	25	to	to	PART
eurjchem-2615	60	26	target	target	VERB
eurjchem-2615	60	27	enzymes	enzyme	NOUN
eurjchem-2615	60	28	[	[	X
eurjchem-2615	60	29	31	31	NUM
eurjchem-2615	60	30	]	]	PUNCT
eurjchem-2615	60	31	.	.	PUNCT
eurjchem-2615	61	1	the	the	DET
eurjchem-2615	61	2	hydrogen	hydrogen	NOUN
eurjchem-2615	61	3	bond	bond	NOUN
eurjchem-2615	61	4	capabilities	capability	NOUN
eurjchem-2615	61	5	of	of	ADP
eurjchem-2615	61	6	the	the	DET
eurjchem-2615	61	7	triazole	triazole	NOUN
eurjchem-2615	61	8	ring	ring	NOUN
eurjchem-2615	61	9	and	and	CCONJ
eurjchem-2615	61	10	rigid	rigid	ADJ
eurjchem-2615	61	11	geometry	geometry	NOUN
eurjchem-2615	61	12	have	have	AUX
eurjchem-2615	61	13	been	be	AUX
eurjchem-2615	61	14	proven	prove	VERB
eurjchem-2615	61	15	to	to	PART
eurjchem-2615	61	16	be	be	AUX
eurjchem-2615	61	17	particularly	particularly	ADV
eurjchem-2615	61	18	valuable	valuable	ADJ
eurjchem-2615	61	19	in	in	ADP
eurjchem-2615	61	20	optimizing	optimize	VERB
eurjchem-2615	61	21	drug	drug	NOUN
eurjchem-2615	61	22	-	-	PUNCT
eurjchem-2615	61	23	target	target	NOUN
eurjchem-2615	61	24	interactions	interaction	NOUN
eurjchem-2615	61	25	.	.	PUNCT
eurjchem-2615	62	1	zimo	zimo	VERB
eurjchem-2615	62	2	and	and	CCONJ
eurjchem-2615	62	3	coghi	coghi	PROPN
eurjchem-2615	62	4	/	/	SYM
eurjchem-2615	62	5	european	european	PROPN
eurjchem-2615	62	6	journal	journal	PROPN
eurjchem-2615	62	7	of	of	ADP
eurjchem-2615	62	8	chemistry	chemistry	NOUN
eurjchem-2615	62	9	16	16	NUM
eurjchem-2615	62	10	(	(	PUNCT
eurjchem-2615	62	11	1	1	NUM
eurjchem-2615	62	12	)	)	PUNCT
eurjchem-2615	62	13	(	(	PUNCT
eurjchem-2615	62	14	2025	2025	NUM
eurjchem-2615	62	15	)	)	PUNCT
eurjchem-2615	62	16	83	83	NUM
eurjchem-2615	62	17	-	-	SYM
eurjchem-2615	62	18	96	96	NUM
eurjchem-2615	62	19	85	85	NUM
eurjchem-2615	62	20	2025	2025	NUM
eurjchem-2615	62	21	–	–	PUNCT
eurjchem-2615	62	22	european	european	ADJ
eurjchem-2615	62	23	journal	journal	NOUN
eurjchem-2615	62	24	of	of	ADP
eurjchem-2615	62	25	chemistry	chemistry	NOUN
eurjchem-2615	62	26	–	–	PUNCT
eurjchem-2615	62	27	cc	cc	NOUN
eurjchem-2615	62	28	by	by	ADP
eurjchem-2615	62	29	nc	nc	PROPN
eurjchem-2615	62	30	–	–	PUNCT
eurjchem-2615	62	31	doi	doi	NOUN
eurjchem-2615	62	32	:	:	PUNCT
eurjchem-2615	62	33	10.5155	10.5155	NUM
eurjchem-2615	62	34	/	/	SYM
eurjchem-2615	62	35	eurjchem.16.1.83	eurjchem.16.1.83	ADJ
eurjchem-2615	62	36	-	-	PUNCT
eurjchem-2615	62	37	96.2615	96.2615	NUM
eurjchem-2615	62	38	n	n	CCONJ
eurjchem-2615	62	39	n	n	CCONJ
eurjchem-2615	62	40	n	n	ADV
eurjchem-2615	62	41	r	r	NOUN
eurjchem-2615	62	42	’	'	PUNCT
eurjchem-2615	62	43	r	r	NOUN
eurjchem-2615	62	44	[	[	X
eurjchem-2615	62	45	cu	cu	X
eurjchem-2615	62	46	]	]	X
eurjchem-2615	62	47	n	n	CCONJ
eurjchem-2615	62	48	n	n	CCONJ
eurjchem-2615	62	49	n	n	ADV
eurjchem-2615	62	50	r	r	NOUN
eurjchem-2615	62	51	’	'	PUNCT
eurjchem-2615	62	52	r	r	NOUN
eurjchem-2615	62	53	[	[	X
eurjchem-2615	62	54	cu	cu	X
eurjchem-2615	62	55	]	]	X
eurjchem-2615	62	56	h	h	NOUN
eurjchem-2615	62	57	’	'	PUNCT
eurjchem-2615	63	1	[	[	X
eurjchem-2615	63	2	cu	cu	X
eurjchem-2615	63	3	]	]	X
eurjchem-2615	63	4	r	r	NOUN
eurjchem-2615	63	5	h	h	NOUN
eurjchem-2615	63	6	r	r	NOUN
eurjchem-2615	63	7	h	h	NOUN
eurjchem-2615	64	1	[	[	X
eurjchem-2615	64	2	cu	cu	X
eurjchem-2615	64	3	]	]	X
eurjchem-2615	64	4	[	[	X
eurjchem-2615	64	5	cu	cu	X
eurjchem-2615	64	6	]	]	X
eurjchem-2615	64	7	h	h	NOUN
eurjchem-2615	64	8	’	'	PUNCT
eurjchem-2615	64	9	r	r	NOUN
eurjchem-2615	64	10	h	h	NOUN
eurjchem-2615	65	1	[	[	X
eurjchem-2615	65	2	cu	cu	X
eurjchem-2615	65	3	]	]	X
eurjchem-2615	65	4	n3	n3	PROPN
eurjchem-2615	65	5	r	r	NOUN
eurjchem-2615	65	6	’	'	PUNCT
eurjchem-2615	65	7	r	r	NOUN
eurjchem-2615	65	8	cu	cu	NOUN
eurjchem-2615	65	9	[	[	X
eurjchem-2615	65	10	cu	cu	X
eurjchem-2615	65	11	]	]	X
eurjchem-2615	65	12	n	n	PRON
eurjchem-2615	65	13	r	r	NOUN
eurjchem-2615	65	14	’	'	PUNCT
eurjchem-2615	65	15	n	n	CCONJ
eurjchem-2615	65	16	nn	nn	INTJ
eurjchem-2615	65	17	n	n	CCONJ
eurjchem-2615	65	18	r	r	NOUN
eurjchem-2615	65	19	[	[	X
eurjchem-2615	65	20	cu	cu	X
eurjchem-2615	65	21	]	]	X
eurjchem-2615	65	22	n	n	PROPN
eurjchem-2615	65	23	[	[	X
eurjchem-2615	65	24	cu	cu	X
eurjchem-2615	65	25	]	]	X
eurjchem-2615	65	26	r	r	AUX
eurjchem-2615	65	27	’	'	PUNCT
eurjchem-2615	65	28	[	[	X
eurjchem-2615	65	29	cu	cu	X
eurjchem-2615	65	30	]	]	X
eurjchem-2615	65	31	(	(	PUNCT
eurjchem-2615	65	32	a	a	NOUN
eurjchem-2615	65	33	)	)	PUNCT
eurjchem-2615	65	34	(	(	PUNCT
eurjchem-2615	65	35	b	b	X
eurjchem-2615	65	36	)	)	PUNCT
eurjchem-2615	65	37	+	+	CCONJ
eurjchem-2615	65	38	n3	n3	ADJ
eurjchem-2615	65	39	n	n	CCONJ
eurjchem-2615	65	40	n	n	CCONJ
eurjchem-2615	65	41	n	n	NOUN
eurjchem-2615	65	42	+	+	CCONJ
eurjchem-2615	65	43	n3	n3	ADJ
eurjchem-2615	65	44	n	n	CCONJ
eurjchem-2615	65	45	n	n	CCONJ
eurjchem-2615	65	46	n	n	PRON
eurjchem-2615	65	47	figure	figure	NOUN
eurjchem-2615	65	48	2	2	NUM
eurjchem-2615	65	49	.	.	PUNCT
eurjchem-2615	66	1	(	(	PUNCT
eurjchem-2615	66	2	a	a	PRON
eurjchem-2615	66	3	)	)	PUNCT
eurjchem-2615	66	4	mechanism	mechanism	NOUN
eurjchem-2615	66	5	of	of	ADP
eurjchem-2615	66	6	the	the	DET
eurjchem-2615	66	7	copper	copper	NOUN
eurjchem-2615	66	8	-	-	PUNCT
eurjchem-2615	66	9	catalyzed	catalyze	VERB
eurjchem-2615	66	10	azide	azide	NOUN
eurjchem-2615	66	11	-	-	PUNCT
eurjchem-2615	66	12	alkyne	alkyne	NOUN
eurjchem-2615	66	13	aycloaddition	aycloaddition	NOUN
eurjchem-2615	66	14	(	(	PUNCT
eurjchem-2615	66	15	cuaac	cuaac	NOUN
eurjchem-2615	66	16	)	)	PUNCT
eurjchem-2615	66	17	.	.	PUNCT
eurjchem-2615	67	1	the	the	DET
eurjchem-2615	67	2	diagram	diagram	NOUN
eurjchem-2615	67	3	illustrates	illustrate	VERB
eurjchem-2615	67	4	the	the	DET
eurjchem-2615	67	5	copper(i)-catalyzed	copper(i)-catalyzed	ADJ
eurjchem-2615	67	6	azide	azide	NOUN
eurjchem-2615	67	7	-	-	PUNCT
eurjchem-2615	67	8	alkyne	alkyne	NOUN
eurjchem-2615	67	9	cycloaddition	cycloaddition	NOUN
eurjchem-2615	67	10	(	(	PUNCT
eurjchem-2615	67	11	cuaac	cuaac	NOUN
eurjchem-2615	67	12	)	)	PUNCT
eurjchem-2615	67	13	process	process	NOUN
eurjchem-2615	67	14	,	,	PUNCT
eurjchem-2615	67	15	showing	show	VERB
eurjchem-2615	67	16	the	the	DET
eurjchem-2615	67	17	formation	formation	NOUN
eurjchem-2615	67	18	of	of	ADP
eurjchem-2615	67	19	1,2,3	1,2,3	NUM
eurjchem-2615	67	20	-	-	NOUN
eurjchem-2615	67	21	triazoles	triazole	NOUN
eurjchem-2615	67	22	from	from	ADP
eurjchem-2615	67	23	azide	azide	NOUN
eurjchem-2615	67	24	and	and	CCONJ
eurjchem-2615	67	25	alkyne	alkyne	NOUN
eurjchem-2615	67	26	reactants	reactant	NOUN
eurjchem-2615	67	27	.	.	PUNCT
eurjchem-2615	68	1	(	(	PUNCT
eurjchem-2615	68	2	b	b	NOUN
eurjchem-2615	68	3	)	)	PUNCT
eurjchem-2615	68	4	mechanism	mechanism	NOUN
eurjchem-2615	68	5	of	of	ADP
eurjchem-2615	68	6	the	the	DET
eurjchem-2615	68	7	strain	strain	NOUN
eurjchem-2615	68	8	-	-	PUNCT
eurjchem-2615	68	9	promoted	promote	VERB
eurjchem-2615	68	10	azide	azide	NOUN
eurjchem-2615	68	11	-	-	PUNCT
eurjchem-2615	68	12	alkyne	alkyne	NOUN
eurjchem-2615	68	13	cycloaddition	cycloaddition	NOUN
eurjchem-2615	68	14	.	.	PUNCT
eurjchem-2615	69	1	the	the	DET
eurjchem-2615	69	2	figure	figure	NOUN
eurjchem-2615	69	3	illustrates	illustrate	VERB
eurjchem-2615	69	4	the	the	DET
eurjchem-2615	69	5	use	use	NOUN
eurjchem-2615	69	6	of	of	ADP
eurjchem-2615	69	7	the	the	DET
eurjchem-2615	69	8	cyclooctyne	cyclooctyne	NOUN
eurjchem-2615	69	9	ring	ring	NOUN
eurjchem-2615	69	10	tension	tension	NOUN
eurjchem-2615	69	11	to	to	PART
eurjchem-2615	69	12	promote	promote	VERB
eurjchem-2615	69	13	1,3	1,3	NUM
eurjchem-2615	69	14	-	-	PUNCT
eurjchem-2615	69	15	dipole	dipole	NOUN
eurjchem-2615	69	16	cycloaddition	cycloaddition	NOUN
eurjchem-2615	69	17	with	with	ADP
eurjchem-2615	69	18	azide	azide	NOUN
eurjchem-2615	69	19	groups	group	NOUN
eurjchem-2615	69	20	.	.	PUNCT
eurjchem-2615	70	1	cuaac	cuaac	PROPN
eurjchem-2615	70	2	also	also	ADV
eurjchem-2615	70	3	facilitates	facilitate	VERB
eurjchem-2615	70	4	the	the	DET
eurjchem-2615	70	5	creation	creation	NOUN
eurjchem-2615	70	6	of	of	ADP
eurjchem-2615	70	7	hybrid	hybrid	ADJ
eurjchem-2615	70	8	molecules	molecule	NOUN
eurjchem-2615	70	9	,	,	PUNCT
eurjchem-2615	70	10	combining	combine	VERB
eurjchem-2615	70	11	tb	tb	ADP
eurjchem-2615	70	12	drugs	drug	NOUN
eurjchem-2615	70	13	with	with	ADP
eurjchem-2615	70	14	other	other	ADJ
eurjchem-2615	70	15	bioactive	bioactive	ADJ
eurjchem-2615	70	16	compounds	compound	NOUN
eurjchem-2615	70	17	[	[	X
eurjchem-2615	70	18	32	32	NUM
eurjchem-2615	70	19	]	]	PUNCT
eurjchem-2615	70	20	.	.	PUNCT
eurjchem-2615	71	1	this	this	DET
eurjchem-2615	71	2	approach	approach	NOUN
eurjchem-2615	71	3	has	have	AUX
eurjchem-2615	71	4	yielded	yield	VERB
eurjchem-2615	71	5	dual	dual	ADJ
eurjchem-2615	71	6	-	-	PUNCT
eurjchem-2615	71	7	action	action	NOUN
eurjchem-2615	71	8	compounds	compound	NOUN
eurjchem-2615	71	9	,	,	PUNCT
eurjchem-2615	71	10	where	where	SCONJ
eurjchem-2615	71	11	the	the	DET
eurjchem-2615	71	12	triazole	triazole	NOUN
eurjchem-2615	71	13	linker	linker	NOUN
eurjchem-2615	71	14	not	not	PART
eurjchem-2615	71	15	only	only	ADV
eurjchem-2615	71	16	connects	connect	VERB
eurjchem-2615	71	17	the	the	DET
eurjchem-2615	71	18	pharmacophores	pharmacophore	NOUN
eurjchem-2615	71	19	but	but	CCONJ
eurjchem-2615	71	20	also	also	ADV
eurjchem-2615	71	21	contributes	contribute	VERB
eurjchem-2615	71	22	to	to	ADP
eurjchem-2615	71	23	the	the	DET
eurjchem-2615	71	24	overall	overall	ADJ
eurjchem-2615	71	25	biological	biological	ADJ
eurjchem-2615	71	26	activity	activity	NOUN
eurjchem-2615	71	27	.	.	PUNCT
eurjchem-2615	72	1	the	the	DET
eurjchem-2615	72	2	synthetic	synthetic	ADJ
eurjchem-2615	72	3	flexibility	flexibility	NOUN
eurjchem-2615	72	4	of	of	ADP
eurjchem-2615	72	5	cuaac	cuaac	NOUN
eurjchem-2615	72	6	allows	allow	VERB
eurjchem-2615	72	7	systematic	systematic	ADJ
eurjchem-2615	72	8	exploration	exploration	NOUN
eurjchem-2615	72	9	of	of	ADP
eurjchem-2615	72	10	linker	linker	NOUN
eurjchem-2615	72	11	length	length	NOUN
eurjchem-2615	72	12	and	and	CCONJ
eurjchem-2615	72	13	positioning	positioning	NOUN
eurjchem-2615	72	14	,	,	PUNCT
eurjchem-2615	72	15	which	which	PRON
eurjchem-2615	72	16	are	be	AUX
eurjchem-2615	72	17	critical	critical	ADJ
eurjchem-2615	72	18	to	to	ADP
eurjchem-2615	72	19	optimizing	optimize	VERB
eurjchem-2615	72	20	the	the	DET
eurjchem-2615	72	21	efficacy	efficacy	NOUN
eurjchem-2615	72	22	of	of	ADP
eurjchem-2615	72	23	hybrid	hybrid	ADJ
eurjchem-2615	72	24	molecules	molecule	NOUN
eurjchem-2615	72	25	.	.	PUNCT
eurjchem-2615	73	1	the	the	DET
eurjchem-2615	73	2	reaction	reaction	NOUN
eurjchem-2615	73	3	enables	enable	VERB
eurjchem-2615	73	4	the	the	DET
eurjchem-2615	73	5	development	development	NOUN
eurjchem-2615	73	6	of	of	ADP
eurjchem-2615	73	7	conjugated	conjugated	ADJ
eurjchem-2615	73	8	delivery	delivery	NOUN
eurjchem-2615	73	9	systems	system	NOUN
eurjchem-2615	73	10	,	,	PUNCT
eurjchem-2615	73	11	particularly	particularly	ADV
eurjchem-2615	73	12	in	in	ADP
eurjchem-2615	73	13	the	the	DET
eurjchem-2615	73	14	creation	creation	NOUN
eurjchem-2615	73	15	of	of	ADP
eurjchem-2615	73	16	targeted	target	VERB
eurjchem-2615	73	17	nanocarriers	nanocarrier	NOUN
eurjchem-2615	73	18	[	[	X
eurjchem-2615	73	19	33	33	NUM
eurjchem-2615	73	20	]	]	PUNCT
eurjchem-2615	73	21	.	.	PUNCT
eurjchem-2615	74	1	here	here	ADV
eurjchem-2615	74	2	,	,	PUNCT
eurjchem-2615	74	3	the	the	DET
eurjchem-2615	74	4	efficiency	efficiency	NOUN
eurjchem-2615	74	5	of	of	ADP
eurjchem-2615	74	6	cuaac	cuaac	NOUN
eurjchem-2615	74	7	in	in	ADP
eurjchem-2615	74	8	aqueous	aqueous	ADJ
eurjchem-2615	74	9	conditions	condition	NOUN
eurjchem-2615	74	10	proves	prove	VERB
eurjchem-2615	74	11	crucial	crucial	ADJ
eurjchem-2615	74	12	for	for	ADP
eurjchem-2615	74	13	the	the	DET
eurjchem-2615	74	14	surface	surface	NOUN
eurjchem-2615	74	15	modification	modification	NOUN
eurjchem-2615	74	16	of	of	ADP
eurjchem-2615	74	17	delivery	delivery	NOUN
eurjchem-2615	74	18	vehicles	vehicle	NOUN
eurjchem-2615	74	19	,	,	PUNCT
eurjchem-2615	74	20	allowing	allow	VERB
eurjchem-2615	74	21	the	the	DET
eurjchem-2615	74	22	attachment	attachment	NOUN
eurjchem-2615	74	23	of	of	ADP
eurjchem-2615	74	24	targeting	target	VERB
eurjchem-2615	74	25	ligands	ligand	NOUN
eurjchem-2615	74	26	and	and	CCONJ
eurjchem-2615	74	27	drug	drug	NOUN
eurjchem-2615	74	28	molecules	molecule	NOUN
eurjchem-2615	74	29	while	while	SCONJ
eurjchem-2615	74	30	maintaining	maintain	VERB
eurjchem-2615	74	31	their	their	PRON
eurjchem-2615	74	32	biological	biological	ADJ
eurjchem-2615	74	33	activity	activity	NOUN
eurjchem-2615	74	34	.	.	PUNCT
eurjchem-2615	75	1	the	the	DET
eurjchem-2615	75	2	mubarak	mubarak	PROPN
eurjchem-2615	75	3	h.	h.	PROPN
eurjchem-2615	75	4	shaikh	shaikh	PROPN
eurjchem-2615	75	5	research	research	PROPN
eurjchem-2615	75	6	group	group	NOUN
eurjchem-2615	75	7	employed	employ	VERB
eurjchem-2615	75	8	cuaac	cuaac	NOUN
eurjchem-2615	75	9	methodology	methodology	NOUN
eurjchem-2615	75	10	to	to	PART
eurjchem-2615	75	11	design	design	VERB
eurjchem-2615	75	12	and	and	CCONJ
eurjchem-2615	75	13	synthesize	synthesize	VERB
eurjchem-2615	75	14	novel	novel	ADJ
eurjchem-2615	75	15	isoniazidcoumarin	isoniazidcoumarin	NOUN
eurjchem-2615	75	16	hybrid	hybrid	ADJ
eurjchem-2615	75	17	molecules	molecule	NOUN
eurjchem-2615	75	18	.	.	PUNCT
eurjchem-2615	76	1	the	the	DET
eurjchem-2615	76	2	synthesized	synthesize	VERB
eurjchem-2615	76	3	compounds	compound	NOUN
eurjchem-2615	76	4	demonstrated	demonstrate	VERB
eurjchem-2615	76	5	minimum	minimum	ADJ
eurjchem-2615	76	6	inhibitory	inhibitory	ADJ
eurjchem-2615	76	7	concentrations	concentration	NOUN
eurjchem-2615	76	8	(	(	PUNCT
eurjchem-2615	76	9	mic	mic	ADJ
eurjchem-2615	76	10	)	)	PUNCT
eurjchem-2615	76	11	as	as	ADV
eurjchem-2615	76	12	low	low	ADJ
eurjchem-2615	76	13	as	as	ADP
eurjchem-2615	76	14	0.12	0.12	NUM
eurjchem-2615	76	15	μg	μg	NOUN
eurjchem-2615	76	16	/	/	SYM
eurjchem-2615	76	17	ml	ml	X
eurjchem-2615	76	18	against	against	ADP
eurjchem-2615	76	19	m.	m.	NOUN
eurjchem-2615	76	20	tuberculosis	tuberculosis	NOUN
eurjchem-2615	76	21	h37rv	h37rv	PROPN
eurjchem-2615	76	22	strain	strain	NOUN
eurjchem-2615	76	23	.	.	PUNCT
eurjchem-2615	77	1	structureactivity	structureactivity	NOUN
eurjchem-2615	77	2	relationship	relationship	NOUN
eurjchem-2615	77	3	analysis	analysis	NOUN
eurjchem-2615	77	4	revealed	reveal	VERB
eurjchem-2615	77	5	that	that	SCONJ
eurjchem-2615	77	6	electron	electron	NOUN
eurjchem-2615	77	7	-	-	PUNCT
eurjchem-2615	77	8	withdrawing	withdraw	VERB
eurjchem-2615	77	9	substituents	substituent	NOUN
eurjchem-2615	77	10	on	on	ADP
eurjchem-2615	77	11	the	the	DET
eurjchem-2615	77	12	coumarin	coumarin	NOUN
eurjchem-2615	77	13	ring	ring	NOUN
eurjchem-2615	77	14	enhanced	enhance	VERB
eurjchem-2615	77	15	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	77	16	activity	activity	NOUN
eurjchem-2615	77	17	,	,	PUNCT
eurjchem-2615	77	18	while	while	SCONJ
eurjchem-2615	77	19	electron	electron	NOUN
eurjchem-2615	77	20	-	-	PUNCT
eurjchem-2615	77	21	donating	donate	VERB
eurjchem-2615	77	22	substituents	substituent	NOUN
eurjchem-2615	77	23	diminished	diminish	VERB
eurjchem-2615	77	24	potency	potency	NOUN
eurjchem-2615	77	25	.	.	PUNCT
eurjchem-2615	78	1	this	this	DET
eurjchem-2615	78	2	investigation	investigation	NOUN
eurjchem-2615	78	3	exemplifies	exemplify	VERB
eurjchem-2615	78	4	the	the	DET
eurjchem-2615	78	5	successful	successful	ADJ
eurjchem-2615	78	6	application	application	NOUN
eurjchem-2615	78	7	of	of	ADP
eurjchem-2615	78	8	click	click	VERB
eurjchem-2615	78	9	chemistry	chemistry	NOUN
eurjchem-2615	78	10	in	in	ADP
eurjchem-2615	78	11	the	the	DET
eurjchem-2615	78	12	development	development	NOUN
eurjchem-2615	78	13	of	of	ADP
eurjchem-2615	78	14	potential	potential	ADJ
eurjchem-2615	78	15	antituberculosis	antituberculosis	NOUN
eurjchem-2615	78	16	agents	agent	NOUN
eurjchem-2615	78	17	through	through	ADP
eurjchem-2615	78	18	the	the	DET
eurjchem-2615	78	19	strategic	strategic	ADJ
eurjchem-2615	78	20	integration	integration	NOUN
eurjchem-2615	78	21	of	of	ADP
eurjchem-2615	78	22	pharmacophoric	pharmacophoric	ADJ
eurjchem-2615	78	23	features	feature	NOUN
eurjchem-2615	78	24	of	of	ADP
eurjchem-2615	78	25	isoniazid	isoniazid	NOUN
eurjchem-2615	78	26	and	and	CCONJ
eurjchem-2615	78	27	coumarin	coumarin	NOUN
eurjchem-2615	78	28	scaffolds	scaffold	NOUN
eurjchem-2615	78	29	[	[	X
eurjchem-2615	78	30	34	34	NUM
eurjchem-2615	78	31	]	]	PUNCT
eurjchem-2615	78	32	.	.	PUNCT
eurjchem-2615	79	1	in	in	ADP
eurjchem-2615	79	2	mycobacterial	mycobacterial	ADJ
eurjchem-2615	79	3	systems	system	NOUN
eurjchem-2615	79	4	,	,	PUNCT
eurjchem-2615	79	5	the	the	DET
eurjchem-2615	79	6	application	application	NOUN
eurjchem-2615	79	7	of	of	ADP
eurjchem-2615	79	8	click	click	NOUN
eurjchem-2615	79	9	chemistry	chemistry	NOUN
eurjchem-2615	79	10	necessitates	necessitate	VERB
eurjchem-2615	79	11	careful	careful	ADJ
eurjchem-2615	79	12	consideration	consideration	NOUN
eurjchem-2615	79	13	of	of	ADP
eurjchem-2615	79	14	reaction	reaction	NOUN
eurjchem-2615	79	15	parameters	parameter	NOUN
eurjchem-2615	79	16	,	,	PUNCT
eurjchem-2615	79	17	including	include	VERB
eurjchem-2615	79	18	catalyst	catalyst	NOUN
eurjchem-2615	79	19	selection	selection	NOUN
eurjchem-2615	79	20	,	,	PUNCT
eurjchem-2615	79	21	ph	ph	ADJ
eurjchem-2615	79	22	optimization	optimization	NOUN
eurjchem-2615	79	23	,	,	PUNCT
eurjchem-2615	79	24	and	and	CCONJ
eurjchem-2615	79	25	solvent	solvent	ADJ
eurjchem-2615	79	26	compatibility	compatibility	NOUN
eurjchem-2615	79	27	.	.	PUNCT
eurjchem-2615	80	1	the	the	DET
eurjchem-2615	80	2	emergence	emergence	NOUN
eurjchem-2615	80	3	of	of	ADP
eurjchem-2615	80	4	copper	copper	NOUN
eurjchem-2615	80	5	-	-	PUNCT
eurjchem-2615	80	6	free	free	ADJ
eurjchem-2615	80	7	alternatives	alternative	NOUN
eurjchem-2615	80	8	,	,	PUNCT
eurjchem-2615	80	9	particularly	particularly	ADV
eurjchem-2615	80	10	strain	strain	NOUN
eurjchem-2615	80	11	-	-	PUNCT
eurjchem-2615	80	12	promoted	promote	VERB
eurjchem-2615	80	13	azide	azide	NOUN
eurjchem-2615	80	14	-	-	PUNCT
eurjchem-2615	80	15	alkyne	alkyne	NOUN
eurjchem-2615	80	16	cycloaddition	cycloaddition	NOUN
eurjchem-2615	80	17	(	(	PUNCT
eurjchem-2615	80	18	spaac	spaac	NOUN
eurjchem-2615	80	19	)	)	PUNCT
eurjchem-2615	80	20	(	(	PUNCT
eurjchem-2615	80	21	figure	figure	NOUN
eurjchem-2615	80	22	1	1	NUM
eurjchem-2615	80	23	)	)	PUNCT
eurjchem-2615	80	24	,	,	PUNCT
eurjchem-2615	80	25	has	have	AUX
eurjchem-2615	80	26	addressed	address	VERB
eurjchem-2615	80	27	concerns	concern	NOUN
eurjchem-2615	80	28	about	about	ADP
eurjchem-2615	80	29	copper	copper	NOUN
eurjchem-2615	80	30	toxicity	toxicity	NOUN
eurjchem-2615	80	31	in	in	ADP
eurjchem-2615	80	32	biological	biological	ADJ
eurjchem-2615	80	33	systems	system	NOUN
eurjchem-2615	80	34	,	,	PUNCT
eurjchem-2615	80	35	facilitating	facilitate	VERB
eurjchem-2615	80	36	live	live	ADJ
eurjchem-2615	80	37	-	-	PUNCT
eurjchem-2615	80	38	cell	cell	NOUN
eurjchem-2615	80	39	applications	application	NOUN
eurjchem-2615	80	40	and	and	CCONJ
eurjchem-2615	80	41	intracellular	intracellular	ADJ
eurjchem-2615	80	42	targeting	targeting	NOUN
eurjchem-2615	80	43	of	of	ADP
eurjchem-2615	80	44	mycobacterial	mycobacterial	ADJ
eurjchem-2615	80	45	components	component	NOUN
eurjchem-2615	80	46	.	.	PUNCT
eurjchem-2615	81	1	these	these	DET
eurjchem-2615	81	2	methodologies	methodology	NOUN
eurjchem-2615	81	3	have	have	AUX
eurjchem-2615	81	4	proven	prove	VERB
eurjchem-2615	81	5	instrumental	instrumental	ADJ
eurjchem-2615	81	6	in	in	ADP
eurjchem-2615	81	7	developing	develop	VERB
eurjchem-2615	81	8	fluorescent	fluorescent	ADJ
eurjchem-2615	81	9	probes	probe	NOUN
eurjchem-2615	81	10	to	to	PART
eurjchem-2615	81	11	study	study	VERB
eurjchem-2615	81	12	the	the	DET
eurjchem-2615	81	13	assembly	assembly	NOUN
eurjchem-2615	81	14	and	and	CCONJ
eurjchem-2615	81	15	metabolic	metabolic	NOUN
eurjchem-2615	81	16	processes	process	NOUN
eurjchem-2615	81	17	of	of	ADP
eurjchem-2615	81	18	mycobacterial	mycobacterial	ADJ
eurjchem-2615	81	19	cell	cell	NOUN
eurjchem-2615	81	20	walls	wall	NOUN
eurjchem-2615	81	21	[	[	X
eurjchem-2615	81	22	35	35	NUM
eurjchem-2615	81	23	]	]	SYM
eurjchem-2615	81	24	.	.	PUNCT
eurjchem-2615	82	1	anna	anna	PROPN
eurjchem-2615	82	2	krajczyk	krajczyk	PROPN
eurjchem-2615	82	3	’s	’s	PART
eurjchem-2615	82	4	team	team	NOUN
eurjchem-2615	82	5	engineered	engineer	VERB
eurjchem-2615	82	6	a	a	DET
eurjchem-2615	82	7	series	series	NOUN
eurjchem-2615	82	8	of	of	ADP
eurjchem-2615	82	9	5’-o-[n(salicylidene	5’-o-[n(salicylidene	NUM
eurjchem-2615	82	10	)	)	PUNCT
eurjchem-2615	82	11	aminosulfonyl]-2	aminosulfonyl]-2	PROPN
eurjchem-2615	82	12	-	-	PUNCT
eurjchem-2615	82	13	aryl-8	aryl-8	NOUN
eurjchem-2615	82	14	-	-	PUNCT
eurjchem-2615	82	15	azido-3	azido-3	NOUN
eurjchem-2615	82	16	-	-	PUNCT
eurjchem-2615	82	17	deazaadenosines	deazaadenosine	NOUN
eurjchem-2615	82	18	catalytically	catalytically	ADV
eurjchem-2615	82	19	catalyzed	catalyze	VERB
eurjchem-2615	82	20	by	by	ADP
eurjchem-2615	82	21	copper	copper	NOUN
eurjchem-2615	82	22	-	-	PUNCT
eurjchem-2615	82	23	free	free	ADJ
eurjchem-2615	82	24	palladium	palladium	NOUN
eurjchem-2615	82	25	to	to	PART
eurjchem-2615	82	26	block	block	VERB
eurjchem-2615	82	27	the	the	DET
eurjchem-2615	82	28	biosynthesis	biosynthesis	NOUN
eurjchem-2615	82	29	of	of	ADP
eurjchem-2615	82	30	mycobacteriocin	mycobacteriocin	NOUN
eurjchem-2615	82	31	in	in	ADP
eurjchem-2615	82	32	mycobacterium	mycobacterium	NOUN
eurjchem-2615	82	33	tuberculosis	tuberculosis	NOUN
eurjchem-2615	82	34	(	(	PUNCT
eurjchem-2615	82	35	mtb	mtb	NOUN
eurjchem-2615	82	36	)	)	PUNCT
eurjchem-2615	82	37	by	by	ADP
eurjchem-2615	82	38	inhibiting	inhibit	VERB
eurjchem-2615	82	39	the	the	DET
eurjchem-2615	82	40	essential	essential	ADJ
eurjchem-2615	82	41	adenylate	adenylate	ADJ
eurjchem-2615	82	42	lyase	lyase	NOUN
eurjchem-2615	82	43	mbta	mbta	NOUN
eurjchem-2615	82	44	.	.	PUNCT
eurjchem-2615	83	1	these	these	DET
eurjchem-2615	83	2	modified	modify	VERB
eurjchem-2615	83	3	nucleosides	nucleoside	NOUN
eurjchem-2615	83	4	were	be	AUX
eurjchem-2615	83	5	shown	show	VERB
eurjchem-2615	83	6	to	to	PART
eurjchem-2615	83	7	inhibit	inhibit	VERB
eurjchem-2615	83	8	mbta	mbta	ADV
eurjchem-2615	83	9	with	with	ADP
eurjchem-2615	83	10	apparent	apparent	ADJ
eurjchem-2615	83	11	ki	ki	PROPN
eurjchem-2615	83	12	values	value	NOUN
eurjchem-2615	83	13	ranging	range	VERB
eurjchem-2615	83	14	from	from	ADP
eurjchem-2615	83	15	6.1	6.1	NUM
eurjchem-2615	83	16	to	to	PART
eurjchem-2615	83	17	25	25	NUM
eurjchem-2615	83	18	nm	nm	NOUN
eurjchem-2615	83	19	and	and	CCONJ
eurjchem-2615	83	20	inhibit	inhibit	VERB
eurjchem-2615	83	21	mtb	mtb	NOUN
eurjchem-2615	83	22	growth	growth	NOUN
eurjchem-2615	83	23	under	under	ADP
eurjchem-2615	83	24	iron	iron	NOUN
eurjchem-2615	83	25	-	-	PUNCT
eurjchem-2615	83	26	deficient	deficient	ADJ
eurjchem-2615	83	27	conditions	condition	NOUN
eurjchem-2615	83	28	with	with	ADP
eurjchem-2615	83	29	minimum	minimum	ADJ
eurjchem-2615	83	30	inhibitory	inhibitory	ADJ
eurjchem-2615	83	31	concentrations	concentration	NOUN
eurjchem-2615	83	32	ranging	range	VERB
eurjchem-2615	83	33	from	from	ADP
eurjchem-2615	83	34	12.5	12.5	NUM
eurjchem-2615	83	35	to	to	ADP
eurjchem-2615	83	36	>	>	SYM
eurjchem-2615	83	37	50	50	NUM
eurjchem-2615	83	38	μm	μm	NOUN
eurjchem-2615	84	1	[	[	X
eurjchem-2615	84	2	36	36	NUM
eurjchem-2615	84	3	]	]	PUNCT
eurjchem-2615	84	4	.	.	PUNCT
eurjchem-2615	85	1	the	the	DET
eurjchem-2615	85	2	mechanistic	mechanistic	ADJ
eurjchem-2615	85	3	versatility	versatility	NOUN
eurjchem-2615	85	4	of	of	ADP
eurjchem-2615	85	5	click	click	NOUN
eurjchem-2615	85	6	reactions	reaction	NOUN
eurjchem-2615	85	7	extends	extend	VERB
eurjchem-2615	85	8	to	to	ADP
eurjchem-2615	85	9	thiol	thiol	NOUN
eurjchem-2615	85	10	-	-	PUNCT
eurjchem-2615	85	11	ene	ene	NOUN
eurjchem-2615	86	1	[	[	X
eurjchem-2615	86	2	37	37	NUM
eurjchem-2615	86	3	]	]	PUNCT
eurjchem-2615	86	4	and	and	CCONJ
eurjchem-2615	86	5	[	[	X
eurjchem-2615	86	6	38	38	NUM
eurjchem-2615	86	7	]	]	PUNCT
eurjchem-2615	86	8	chemistries	chemistry	NOUN
eurjchem-2615	86	9	,	,	PUNCT
eurjchem-2615	86	10	which	which	PRON
eurjchem-2615	86	11	have	have	VERB
eurjchem-2615	86	12	particular	particular	ADJ
eurjchem-2615	86	13	relevance	relevance	NOUN
eurjchem-2615	86	14	in	in	ADP
eurjchem-2615	86	15	targeting	target	VERB
eurjchem-2615	86	16	mycothiol	mycothiol	ADJ
eurjchem-2615	86	17	-	-	PUNCT
eurjchem-2615	86	18	dependent	dependent	ADJ
eurjchem-2615	86	19	processes	process	NOUN
eurjchem-2615	86	20	in	in	ADP
eurjchem-2615	86	21	m.	m.	NOUN
eurjchem-2615	86	22	tuberculosis	tuberculosis	NOUN
eurjchem-2615	86	23	.	.	PUNCT
eurjchem-2615	87	1	these	these	DET
eurjchem-2615	87	2	reactions	reaction	NOUN
eurjchem-2615	87	3	provide	provide	VERB
eurjchem-2615	87	4	complementary	complementary	ADJ
eurjchem-2615	87	5	approaches	approach	NOUN
eurjchem-2615	87	6	for	for	ADP
eurjchem-2615	87	7	drug	drug	NOUN
eurjchem-2615	87	8	modification	modification	NOUN
eurjchem-2615	87	9	and	and	CCONJ
eurjchem-2615	87	10	conjugation	conjugation	NOUN
eurjchem-2615	87	11	,	,	PUNCT
eurjchem-2615	87	12	expanding	expand	VERB
eurjchem-2615	87	13	the	the	DET
eurjchem-2615	87	14	synthetic	synthetic	ADJ
eurjchem-2615	87	15	toolkit	toolkit	NOUN
eurjchem-2615	87	16	available	available	ADJ
eurjchem-2615	87	17	for	for	ADP
eurjchem-2615	87	18	anti	anti	ADJ
eurjchem-2615	87	19	-	-	ADJ
eurjchem-2615	87	20	tb	tb	ADJ
eurjchem-2615	87	21	drug	drug	NOUN
eurjchem-2615	87	22	development	development	NOUN
eurjchem-2615	87	23	.	.	PUNCT
eurjchem-2615	88	1	the	the	DET
eurjchem-2615	88	2	optimization	optimization	NOUN
eurjchem-2615	88	3	of	of	ADP
eurjchem-2615	88	4	these	these	DET
eurjchem-2615	88	5	reactions	reaction	NOUN
eurjchem-2615	88	6	for	for	ADP
eurjchem-2615	88	7	mycobacterial	mycobacterial	ADJ
eurjchem-2615	88	8	applications	application	NOUN
eurjchem-2615	88	9	has	have	AUX
eurjchem-2615	88	10	required	require	VERB
eurjchem-2615	88	11	a	a	DET
eurjchem-2615	88	12	systematic	systematic	ADJ
eurjchem-2615	88	13	evaluation	evaluation	NOUN
eurjchem-2615	88	14	of	of	ADP
eurjchem-2615	88	15	reaction	reaction	NOUN
eurjchem-2615	88	16	kinetics	kinetic	NOUN
eurjchem-2615	88	17	,	,	PUNCT
eurjchem-2615	88	18	stability	stability	NOUN
eurjchem-2615	88	19	profiles	profile	NOUN
eurjchem-2615	88	20	,	,	PUNCT
eurjchem-2615	88	21	and	and	CCONJ
eurjchem-2615	88	22	biological	biological	ADJ
eurjchem-2615	88	23	compatibility	compatibility	NOUN
eurjchem-2615	88	24	,	,	PUNCT
eurjchem-2615	88	25	particularly	particularly	ADV
eurjchem-2615	88	26	regarding	regard	VERB
eurjchem-2615	88	27	cell	cell	NOUN
eurjchem-2615	88	28	wall	wall	NOUN
eurjchem-2615	88	29	penetration	penetration	NOUN
eurjchem-2615	88	30	and	and	CCONJ
eurjchem-2615	88	31	intracellular	intracellular	ADJ
eurjchem-2615	88	32	accessibility	accessibility	NOUN
eurjchem-2615	88	33	.	.	PUNCT
eurjchem-2615	89	1	the	the	DET
eurjchem-2615	89	2	analytical	analytical	ADJ
eurjchem-2615	89	3	validation	validation	NOUN
eurjchem-2615	89	4	of	of	ADP
eurjchem-2615	89	5	click	click	VERB
eurjchem-2615	89	6	chemistry	chemistry	NOUN
eurjchem-2615	89	7	applications	application	NOUN
eurjchem-2615	89	8	in	in	ADP
eurjchem-2615	89	9	tb	tb	ADP
eurjchem-2615	89	10	research	research	NOUN
eurjchem-2615	89	11	employs	employ	VERB
eurjchem-2615	89	12	sophisticated	sophisticated	ADJ
eurjchem-2615	89	13	instrumentation	instrumentation	NOUN
eurjchem-2615	89	14	,	,	PUNCT
eurjchem-2615	89	15	including	include	VERB
eurjchem-2615	89	16	[	[	X
eurjchem-2615	89	17	39	39	NUM
eurjchem-2615	89	18	]	]	PUNCT
eurjchem-2615	89	19	,	,	PUNCT
eurjchem-2615	89	20	advanced	advanced	ADJ
eurjchem-2615	89	21	nmr	nmr	NOUN
eurjchem-2615	89	22	techniques	technique	NOUN
eurjchem-2615	89	23	[	[	X
eurjchem-2615	89	24	40	40	NUM
eurjchem-2615	89	25	]	]	PUNCT
eurjchem-2615	89	26	,	,	PUNCT
eurjchem-2615	89	27	ultrasonic	ultrasonic	ADJ
eurjchem-2615	89	28	irradiationassisted	irradiationassiste	VERB
eurjchem-2615	89	29	method	method	NOUN
eurjchem-2615	89	30	[	[	X
eurjchem-2615	89	31	41	41	NUM
eurjchem-2615	89	32	]	]	PUNCT
eurjchem-2615	89	33	,	,	PUNCT
eurjchem-2615	89	34	and	and	CCONJ
eurjchem-2615	89	35	specialized	specialized	ADJ
eurjchem-2615	89	36	chromatographic	chromatographic	ADJ
eurjchem-2615	89	37	methods	method	NOUN
eurjchem-2615	89	38	[	[	X
eurjchem-2615	89	39	42	42	NUM
eurjchem-2615	89	40	]	]	PUNCT
eurjchem-2615	89	41	.	.	PUNCT
eurjchem-2615	90	1	these	these	DET
eurjchem-2615	90	2	analytical	analytical	ADJ
eurjchem-2615	90	3	approaches	approach	NOUN
eurjchem-2615	90	4	ensure	ensure	VERB
eurjchem-2615	90	5	precise	precise	ADJ
eurjchem-2615	90	6	86	86	NUM
eurjchem-2615	90	7	zimo	zimo	ADJ
eurjchem-2615	90	8	and	and	CCONJ
eurjchem-2615	90	9	coghi	coghi	PROPN
eurjchem-2615	90	10	/	/	SYM
eurjchem-2615	90	11	european	european	PROPN
eurjchem-2615	90	12	journal	journal	PROPN
eurjchem-2615	90	13	of	of	ADP
eurjchem-2615	90	14	chemistry	chemistry	NOUN
eurjchem-2615	90	15	16	16	NUM
eurjchem-2615	90	16	(	(	PUNCT
eurjchem-2615	90	17	1	1	NUM
eurjchem-2615	90	18	)	)	PUNCT
eurjchem-2615	90	19	(	(	PUNCT
eurjchem-2615	90	20	2025	2025	NUM
eurjchem-2615	90	21	)	)	PUNCT
eurjchem-2615	90	22	83	83	NUM
eurjchem-2615	90	23	-	-	SYM
eurjchem-2615	90	24	96	96	NUM
eurjchem-2615	90	25	2025	2025	NUM
eurjchem-2615	90	26	–	–	PUNCT
eurjchem-2615	90	27	european	european	ADJ
eurjchem-2615	90	28	journal	journal	NOUN
eurjchem-2615	90	29	of	of	ADP
eurjchem-2615	90	30	chemistry	chemistry	NOUN
eurjchem-2615	90	31	–	–	PUNCT
eurjchem-2615	90	32	cc	cc	NOUN
eurjchem-2615	90	33	by	by	ADP
eurjchem-2615	90	34	nc	nc	PROPN
eurjchem-2615	90	35	–	–	PUNCT
eurjchem-2615	90	36	doi	doi	NOUN
eurjchem-2615	90	37	:	:	PUNCT
eurjchem-2615	90	38	10.5155	10.5155	NUM
eurjchem-2615	90	39	/	/	SYM
eurjchem-2615	90	40	eurjchem.16.1.83	eurjchem.16.1.83	ADJ
eurjchem-2615	90	41	-	-	PUNCT
eurjchem-2615	90	42	96.2615	96.2615	NUM
eurjchem-2615	90	43	n	n	NUM
eurjchem-2615	90	44	nnh2n	nnh2n	NOUN
eurjchem-2615	90	45	o	o	NOUN
eurjchem-2615	90	46	h2n	h2n	PROPN
eurjchem-2615	90	47	cl	cl	NOUN
eurjchem-2615	90	48	o	o	NOUN
eurjchem-2615	90	49	cl	cl	NOUN
eurjchem-2615	90	50	cl	cl	NOUN
eurjchem-2615	90	51	carboxyamidotriazole	carboxyamidotriazole	NOUN
eurjchem-2615	90	52	(	(	PUNCT
eurjchem-2615	90	53	anticancer	anticancer	NOUN
eurjchem-2615	90	54	)	)	PUNCT
eurjchem-2615	90	55	s	s	PART
eurjchem-2615	90	56	o	o	NOUN
eurjchem-2615	90	57	o	o	X
eurjchem-2615	90	58	thbso	thbso	NOUN
eurjchem-2615	90	59	n	n	CCONJ
eurjchem-2615	90	60	n	n	CCONJ
eurjchem-2615	90	61	n	n	ADV
eurjchem-2615	90	62	nh2	nh2	NOUN
eurjchem-2615	91	1	o	o	NOUN
eurjchem-2615	92	1	o	o	X
eurjchem-2615	92	2	o	o	X
eurjchem-2615	92	3	otbs	otbs	NOUN
eurjchem-2615	92	4	tsao(anti	tsao(anti	PROPN
eurjchem-2615	92	5	-	-	PROPN
eurjchem-2615	92	6	hiv	hiv	PROPN
eurjchem-2615	92	7	)	)	PUNCT
eurjchem-2615	92	8	n	n	PROPN
eurjchem-2615	92	9	s	s	NOUN
eurjchem-2615	92	10	n	n	CCONJ
eurjchem-2615	92	11	n	n	CCONJ
eurjchem-2615	92	12	n	n	ADV
eurjchem-2615	92	13	o	o	NOUN
eurjchem-2615	93	1	oh	oh	INTJ
eurjchem-2615	93	2	o	o	INTJ
eurjchem-2615	93	3	o	o	INTJ
eurjchem-2615	93	4	oh	oh	INTJ
eurjchem-2615	93	5	tazobactum	tazobactum	NOUN
eurjchem-2615	93	6	(	(	PUNCT
eurjchem-2615	93	7	ß	ß	PRON
eurjchem-2615	93	8	-	-	ADJ
eurjchem-2615	93	9	lactum	lactum	NOUN
eurjchem-2615	93	10	antibiotic	antibiotic	ADJ
eurjchem-2615	93	11	)	)	PUNCT
eurjchem-2615	93	12	f	f	PROPN
eurjchem-2615	93	13	n	n	CCONJ
eurjchem-2615	93	14	n	n	CCONJ
eurjchem-2615	93	15	n	n	ADV
eurjchem-2615	93	16	o	o	NOUN
eurjchem-2615	93	17	nh2	nh2	PROPN
eurjchem-2615	93	18	f	f	PROPN
eurjchem-2615	93	19	rufinamide	rufinamide	PROPN
eurjchem-2615	93	20	(	(	PUNCT
eurjchem-2615	93	21	anticonvulsant	anticonvulsant	PROPN
eurjchem-2615	93	22	)	)	PUNCT
eurjchem-2615	93	23	n	n	NOUN
eurjchem-2615	93	24	nn	nn	NOUN
eurjchem-2615	94	1	f	f	X
eurjchem-2615	94	2	f	f	PROPN
eurjchem-2615	95	1	oh	oh	INTJ
eurjchem-2615	95	2	me	i	PRON
eurjchem-2615	95	3	s	s	VERB
eurjchem-2615	95	4	n	n	PRON
eurjchem-2615	95	5	cn	cn	PROPN
eurjchem-2615	95	6	ravucoazole	ravucoazole	PROPN
eurjchem-2615	95	7	(	(	PUNCT
eurjchem-2615	95	8	antifungal	antifungal	PROPN
eurjchem-2615	95	9	)	)	PUNCT
eurjchem-2615	95	10	n	n	CCONJ
eurjchem-2615	95	11	n	n	CCONJ
eurjchem-2615	95	12	n	n	CCONJ
eurjchem-2615	95	13	n	n	CCONJ
eurjchem-2615	95	14	n	n	PRON
eurjchem-2615	95	15	meme	meme	NOUN
eurjchem-2615	95	16	me	me	PROPN
eurjchem-2615	95	17	trapidil	trapidil	NOUN
eurjchem-2615	95	18	(	(	PUNCT
eurjchem-2615	95	19	antiplatelet	antiplatelet	NOUN
eurjchem-2615	95	20	)	)	PUNCT
eurjchem-2615	95	21	n	n	CCONJ
eurjchem-2615	95	22	n	n	CCONJ
eurjchem-2615	95	23	n	n	NOUN
eurjchem-2615	95	24	o	o	NOUN
eurjchem-2615	95	25	n	n	CCONJ
eurjchem-2615	95	26	n	n	PROPN
eurjchem-2615	95	27	cl	cl	NOUN
eurjchem-2615	95	28	trazodone	trazodone	NOUN
eurjchem-2615	95	29	(	(	PUNCT
eurjchem-2615	95	30	antidepressant	antidepressant	ADJ
eurjchem-2615	95	31	)	)	PUNCT
eurjchem-2615	96	1	n	n	NOUN
eurjchem-2615	96	2	h	h	NOUN
eurjchem-2615	96	3	n	n	ADP
eurjchem-2615	96	4	o	o	NOUN
eurjchem-2615	96	5	n	n	CCONJ
eurjchem-2615	96	6	o	o	NOUN
eurjchem-2615	96	7	n	n	CCONJ
eurjchem-2615	96	8	n	n	ADV
eurjchem-2615	96	9	o	o	NOUN
eurjchem-2615	97	1	oh	oh	INTJ
eurjchem-2615	97	2	oho	oho	INTJ
eurjchem-2615	98	1	i	i	PRON
eurjchem-2615	98	2	-	-	PUNCT
eurjchem-2615	98	3	a09	a09	PROPN
eurjchem-2615	98	4	(	(	PUNCT
eurjchem-2615	98	5	anti	anti	ADJ
eurjchem-2615	98	6	-	-	ADJ
eurjchem-2615	98	7	tb	tb	ADP
eurjchem-2615	98	8	agent	agent	NOUN
eurjchem-2615	98	9	,	,	PUNCT
eurjchem-2615	98	10	in	in	ADP
eurjchem-2615	98	11	clinical	clinical	ADJ
eurjchem-2615	98	12	evaluations	evaluation	NOUN
eurjchem-2615	98	13	)	)	PUNCT
eurjchem-2615	99	1	n	n	ADP
eurjchem-2615	99	2	o	o	NOUN
eurjchem-2615	99	3	o	o	NOUN
eurjchem-2615	99	4	n	n	CCONJ
eurjchem-2615	99	5	n	n	CCONJ
eurjchem-2615	99	6	n	n	ADV
eurjchem-2615	99	7	cl	cl	NOUN
eurjchem-2615	99	8	cl	cl	NOUN
eurjchem-2615	99	9	o	o	NOUN
eurjchem-2615	99	10	anticancer	anticancer	NOUN
eurjchem-2615	99	11	n	n	NOUN
eurjchem-2615	99	12	x	x	SYM
eurjchem-2615	99	13	n	n	CCONJ
eurjchem-2615	99	14	n	n	CCONJ
eurjchem-2615	99	15	cl	cl	NOUN
eurjchem-2615	99	16	anti	anti	ADJ
eurjchem-2615	99	17	-	-	ADJ
eurjchem-2615	99	18	bacterial	bacterial	ADJ
eurjchem-2615	99	19	n	n	NOUN
eurjchem-2615	99	20	o	o	NOUN
eurjchem-2615	99	21	o	o	NOUN
eurjchem-2615	99	22	n	n	CCONJ
eurjchem-2615	99	23	n	n	CCONJ
eurjchem-2615	99	24	n	n	CCONJ
eurjchem-2615	99	25	n	n	CCONJ
eurjchem-2615	99	26	n	n	CCONJ
eurjchem-2615	99	27	n	n	NOUN
eurjchem-2615	99	28	f	f	NOUN
eurjchem-2615	99	29	ff	ff	NOUN
eurjchem-2615	99	30	f	f	PROPN
eurjchem-2615	99	31	ff	ff	NOUN
eurjchem-2615	99	32	anticancer	anticancer	NOUN
eurjchem-2615	99	33	figure	figure	NOUN
eurjchem-2615	99	34	3	3	NUM
eurjchem-2615	99	35	.	.	PUNCT
eurjchem-2615	99	36	structure	structure	NOUN
eurjchem-2615	99	37	of	of	ADP
eurjchem-2615	99	38	various	various	ADJ
eurjchem-2615	99	39	triazole	triazole	NOUN
eurjchem-2615	99	40	-	-	PUNCT
eurjchem-2615	99	41	appended	append	VERB
eurjchem-2615	99	42	potent	potent	ADJ
eurjchem-2615	99	43	drug	drug	NOUN
eurjchem-2615	99	44	candidates	candidate	NOUN
eurjchem-2615	99	45	against	against	ADP
eurjchem-2615	99	46	various	various	ADJ
eurjchem-2615	99	47	diseases	disease	NOUN
eurjchem-2615	99	48	.	.	PUNCT
eurjchem-2615	100	1	characterization	characterization	NOUN
eurjchem-2615	100	2	of	of	ADP
eurjchem-2615	100	3	click	click	NOUN
eurjchem-2615	100	4	-	-	PUNCT
eurjchem-2615	100	5	chemistry	chemistry	NOUN
eurjchem-2615	100	6	products	product	NOUN
eurjchem-2615	100	7	and	and	CCONJ
eurjchem-2615	100	8	their	their	PRON
eurjchem-2615	100	9	biological	biological	ADJ
eurjchem-2615	100	10	effects	effect	NOUN
eurjchem-2615	100	11	on	on	ADP
eurjchem-2615	100	12	mycobacterial	mycobacterial	ADJ
eurjchem-2615	100	13	systems	system	NOUN
eurjchem-2615	100	14	,	,	PUNCT
eurjchem-2615	100	15	supporting	support	VERB
eurjchem-2615	100	16	both	both	CCONJ
eurjchem-2615	100	17	drug	drug	NOUN
eurjchem-2615	100	18	development	development	NOUN
eurjchem-2615	100	19	and	and	CCONJ
eurjchem-2615	100	20	mechanistic	mechanistic	ADJ
eurjchem-2615	100	21	studies	study	NOUN
eurjchem-2615	100	22	in	in	ADP
eurjchem-2615	100	23	tb	tb	ADP
eurjchem-2615	100	24	research	research	NOUN
eurjchem-2615	100	25	.	.	PUNCT
eurjchem-2615	101	1	3	3	X
eurjchem-2615	101	2	.	.	X
eurjchem-2615	101	3	triazole	triazole	NOUN
eurjchem-2615	101	4	heterocycle	heterocycle	NOUN
eurjchem-2615	101	5	as	as	ADP
eurjchem-2615	101	6	a	a	DET
eurjchem-2615	101	7	valuable	valuable	ADJ
eurjchem-2615	101	8	scaffold	scaffold	NOUN
eurjchem-2615	101	9	in	in	ADP
eurjchem-2615	101	10	drug	drug	NOUN
eurjchem-2615	101	11	discovery	discovery	NOUN
eurjchem-2615	101	12	triazole	triazole	NOUN
eurjchem-2615	101	13	,	,	PUNCT
eurjchem-2615	101	14	a	a	DET
eurjchem-2615	101	15	fundamental	fundamental	ADJ
eurjchem-2615	101	16	building	building	NOUN
eurjchem-2615	101	17	block	block	NOUN
eurjchem-2615	101	18	,	,	PUNCT
eurjchem-2615	101	19	is	be	AUX
eurjchem-2615	101	20	a	a	DET
eurjchem-2615	101	21	five	five	NUM
eurjchem-2615	101	22	-	-	PUNCT
eurjchem-2615	101	23	member	member	NOUN
eurjchem-2615	101	24	heterocyclic	heterocyclic	NOUN
eurjchem-2615	101	25	compound	compound	NOUN
eurjchem-2615	101	26	with	with	ADP
eurjchem-2615	101	27	three	three	NUM
eurjchem-2615	101	28	nitrogen	nitrogen	NOUN
eurjchem-2615	101	29	atoms	atom	NOUN
eurjchem-2615	101	30	and	and	CCONJ
eurjchem-2615	101	31	exists	exist	VERB
eurjchem-2615	101	32	in	in	ADP
eurjchem-2615	101	33	isomeric	isomeric	ADJ
eurjchem-2615	101	34	forms	form	NOUN
eurjchem-2615	101	35	known	know	VERB
eurjchem-2615	101	36	as	as	ADP
eurjchem-2615	101	37	1,2,3	1,2,3	NOUN
eurjchem-2615	101	38	-	-	NOUN
eurjchem-2615	101	39	triazole	triazole	NOUN
eurjchem-2615	101	40	and	and	CCONJ
eurjchem-2615	101	41	1,2,4	1,2,4	NUM
eurjchem-2615	101	42	-	-	PUNCT
eurjchem-2615	101	43	triazole	triazole	NOUN
eurjchem-2615	101	44	.	.	PUNCT
eurjchem-2615	102	1	natural	natural	ADJ
eurjchem-2615	102	2	and	and	CCONJ
eurjchem-2615	102	3	synthetic	synthetic	ADJ
eurjchem-2615	102	4	molecules	molecule	NOUN
eurjchem-2615	102	5	that	that	PRON
eurjchem-2615	102	6	have	have	VERB
eurjchem-2615	102	7	a	a	DET
eurjchem-2615	102	8	triazole	triazole	ADJ
eurjchem-2615	102	9	framework	framework	NOUN
eurjchem-2615	102	10	attract	attract	VERB
eurjchem-2615	102	11	medicinal	medicinal	ADJ
eurjchem-2615	102	12	chemists	chemist	NOUN
eurjchem-2615	102	13	due	due	ADP
eurjchem-2615	102	14	to	to	ADP
eurjchem-2615	102	15	their	their	PRON
eurjchem-2615	102	16	enormous	enormous	ADJ
eurjchem-2615	102	17	therapeutic	therapeutic	ADJ
eurjchem-2615	102	18	potential	potential	NOUN
eurjchem-2615	102	19	(	(	PUNCT
eurjchem-2615	102	20	figure	figure	NOUN
eurjchem-2615	102	21	3	3	NUM
eurjchem-2615	102	22	)	)	PUNCT
eurjchem-2615	102	23	such	such	ADJ
eurjchem-2615	102	24	as	as	ADP
eurjchem-2615	102	25	antifungal	antifungal	ADJ
eurjchem-2615	102	26	[	[	X
eurjchem-2615	102	27	43	43	NUM
eurjchem-2615	102	28	]	]	PUNCT
eurjchem-2615	102	29	,	,	PUNCT
eurjchem-2615	102	30	antivirus	antivirus	NOUN
eurjchem-2615	103	1	[	[	X
eurjchem-2615	103	2	10,23	10,23	X
eurjchem-2615	103	3	]	]	PUNCT
eurjchem-2615	103	4	,	,	PUNCT
eurjchem-2615	103	5	anticancer	anticancer	NOUN
eurjchem-2615	103	6	[	[	PUNCT
eurjchem-2615	103	7	44	44	NUM
eurjchem-2615	103	8	-	-	SYM
eurjchem-2615	103	9	46	46	NUM
eurjchem-2615	103	10	]	]	PUNCT
eurjchem-2615	103	11	,	,	PUNCT
eurjchem-2615	103	12	antitubercular	antitubercular	ADJ
eurjchem-2615	104	1	[	[	X
eurjchem-2615	104	2	47	47	NUM
eurjchem-2615	104	3	]	]	PUNCT
eurjchem-2615	104	4	,	,	PUNCT
eurjchem-2615	104	5	antibacterial	antibacterial	ADJ
eurjchem-2615	104	6	[	[	X
eurjchem-2615	104	7	48,49	48,49	X
eurjchem-2615	104	8	]	]	X
eurjchem-2615	104	9	,	,	PUNCT
eurjchem-2615	104	10	anticonvulsant	anticonvulsant	PROPN
eurjchem-2615	104	11	[	[	X
eurjchem-2615	104	12	50	50	NUM
eurjchem-2615	104	13	]	]	PUNCT
eurjchem-2615	104	14	and	and	CCONJ
eurjchem-2615	104	15	anti	anti	ADJ
eurjchem-2615	104	16	-	-	ADJ
eurjchem-2615	104	17	inflammatory	inflammatory	ADJ
eurjchem-2615	104	18	[	[	X
eurjchem-2615	104	19	51	51	NUM
eurjchem-2615	104	20	]	]	PUNCT
eurjchem-2615	104	21	.	.	PUNCT
eurjchem-2615	105	1	4	4	NUM
eurjchem-2615	105	2	.	.	X
eurjchem-2615	105	3	1,2,3	1,2,3	NUM
eurjchem-2615	105	4	-	-	ADJ
eurjchem-2615	105	5	triazole	triazole	ADJ
eurjchem-2615	105	6	hybrids	hybrid	NOUN
eurjchem-2615	105	7	as	as	ADP
eurjchem-2615	105	8	potent	potent	ADJ
eurjchem-2615	105	9	anti	anti	ADJ
eurjchem-2615	105	10	-	-	ADJ
eurjchem-2615	105	11	tb	tb	ADJ
eurjchem-2615	105	12	agents	agent	NOUN
eurjchem-2615	105	13	it	it	PRON
eurjchem-2615	105	14	is	be	AUX
eurjchem-2615	105	15	well	well	ADV
eurjchem-2615	105	16	known	know	VERB
eurjchem-2615	105	17	that	that	SCONJ
eurjchem-2615	105	18	1,2,3	1,2,3	NUM
eurjchem-2615	105	19	-	-	NOUN
eurjchem-2615	105	20	triazoles	triazole	NOUN
eurjchem-2615	105	21	and	and	CCONJ
eurjchem-2615	105	22	their	their	PRON
eurjchem-2615	105	23	derivatives	derivative	NOUN
eurjchem-2615	105	24	possess	possess	VERB
eurjchem-2615	105	25	a	a	DET
eurjchem-2615	105	26	wide	wide	ADJ
eurjchem-2615	105	27	range	range	NOUN
eurjchem-2615	105	28	of	of	ADP
eurjchem-2615	105	29	pharmacological	pharmacological	ADJ
eurjchem-2615	105	30	activities	activity	NOUN
eurjchem-2615	105	31	,	,	PUNCT
eurjchem-2615	105	32	including	include	VERB
eurjchem-2615	105	33	antituberculosis	antituberculosis	NOUN
eurjchem-2615	105	34	activity	activity	NOUN
eurjchem-2615	105	35	.	.	PUNCT
eurjchem-2615	106	1	molecular	molecular	ADJ
eurjchem-2615	106	2	hybridization	hybridization	NOUN
eurjchem-2615	106	3	of	of	ADP
eurjchem-2615	106	4	1,2,3triazoles	1,2,3triazoles	NUM
eurjchem-2615	106	5	with	with	ADP
eurjchem-2615	106	6	various	various	ADJ
eurjchem-2615	106	7	pharmacophores	pharmacophore	NOUN
eurjchem-2615	106	8	may	may	AUX
eurjchem-2615	106	9	provide	provide	VERB
eurjchem-2615	106	10	novel	novel	NOUN
eurjchem-2615	106	11	,	,	PUNCT
eurjchem-2615	106	12	effective	effective	ADJ
eurjchem-2615	106	13	,	,	PUNCT
eurjchem-2615	106	14	and	and	CCONJ
eurjchem-2615	106	15	safe	safe	ADJ
eurjchem-2615	106	16	drug	drug	NOUN
eurjchem-2615	106	17	candidates	candidate	NOUN
eurjchem-2615	106	18	to	to	PART
eurjchem-2615	106	19	combat	combat	NOUN
eurjchem-2615	106	20	tuberculosis	tuberculosis	NOUN
eurjchem-2615	106	21	.	.	PUNCT
eurjchem-2615	107	1	this	this	DET
eurjchem-2615	107	2	section	section	NOUN
eurjchem-2615	107	3	will	will	AUX
eurjchem-2615	107	4	introduce	introduce	VERB
eurjchem-2615	107	5	various	various	ADJ
eurjchem-2615	107	6	emerging	emerge	VERB
eurjchem-2615	107	7	1,2,3	1,2,3	NUM
eurjchem-2615	107	8	-	-	PUNCT
eurjchem-2615	107	9	triazole	triazole	NOUN
eurjchem-2615	107	10	compounds	compound	NOUN
eurjchem-2615	107	11	.	.	PUNCT
eurjchem-2615	108	1	4.1	4.1	NUM
eurjchem-2615	108	2	.	.	PUNCT
eurjchem-2615	108	3	azole-1,2,3	azole-1,2,3	ADJ
eurjchem-2615	108	4	-	-	PUNCT
eurjchem-2615	108	5	triazole	triazole	NOUN
eurjchem-2615	108	6	hybrids	hybrid	NOUN
eurjchem-2615	108	7	a	a	DET
eurjchem-2615	108	8	promising	promising	ADJ
eurjchem-2615	108	9	strategy	strategy	NOUN
eurjchem-2615	108	10	involves	involve	VERB
eurjchem-2615	108	11	the	the	DET
eurjchem-2615	108	12	combination	combination	NOUN
eurjchem-2615	108	13	of	of	ADP
eurjchem-2615	108	14	nitroimidazoles	nitroimidazole	NOUN
eurjchem-2615	108	15	with	with	ADP
eurjchem-2615	108	16	1,2,3	1,2,3	NUM
eurjchem-2615	108	17	-	-	PUNCT
eurjchem-2615	108	18	triazoles	triazole	NOUN
eurjchem-2615	108	19	,	,	PUNCT
eurjchem-2615	108	20	given	give	VERB
eurjchem-2615	108	21	that	that	DET
eurjchem-2615	108	22	nitroimidazoles	nitroimidazole	NOUN
eurjchem-2615	108	23	and	and	CCONJ
eurjchem-2615	108	24	related	related	ADJ
eurjchem-2615	108	25	compounds	compound	NOUN
eurjchem-2615	108	26	show	show	VERB
eurjchem-2615	108	27	broad	broad	ADJ
eurjchem-2615	108	28	antimicrobial	antimicrobial	ADJ
eurjchem-2615	108	29	activity	activity	NOUN
eurjchem-2615	108	30	against	against	ADP
eurjchem-2615	108	31	mycobacteria	mycobacterium	NOUN
eurjchem-2615	108	32	,	,	PUNCT
eurjchem-2615	108	33	parasites	parasite	NOUN
eurjchem-2615	108	34	,	,	PUNCT
eurjchem-2615	108	35	and	and	CCONJ
eurjchem-2615	108	36	both	both	DET
eurjchem-2615	108	37	gram	gram	NOUN
eurjchem-2615	108	38	-	-	PUNCT
eurjchem-2615	108	39	positive	positive	ADJ
eurjchem-2615	108	40	and	and	CCONJ
eurjchem-2615	108	41	gram	gram	NOUN
eurjchem-2615	108	42	-	-	PUNCT
eurjchem-2615	108	43	negative	negative	ADJ
eurjchem-2615	108	44	anaerobic	anaerobic	NOUN
eurjchem-2615	108	45	bacteria	bacteria	NOUN
eurjchem-2615	109	1	[	[	X
eurjchem-2615	109	2	52	52	NUM
eurjchem-2615	109	3	]	]	PUNCT
eurjchem-2615	109	4	(	(	PUNCT
eurjchem-2615	109	5	figure	figure	NOUN
eurjchem-2615	109	6	4	4	NUM
eurjchem-2615	109	7	)	)	PUNCT
eurjchem-2615	109	8	.	.	PUNCT
eurjchem-2615	110	1	following	follow	VERB
eurjchem-2615	110	2	this	this	DET
eurjchem-2615	110	3	approach	approach	NOUN
eurjchem-2615	110	4	,	,	PUNCT
eurjchem-2615	110	5	a	a	DET
eurjchem-2615	110	6	structural	structural	ADJ
eurjchem-2615	110	7	modification	modification	NOUN
eurjchem-2615	110	8	of	of	ADP
eurjchem-2615	110	9	the	the	DET
eurjchem-2615	110	10	delamanid	delamanid	NOUN
eurjchem-2615	110	11	was	be	AUX
eurjchem-2615	110	12	performed	perform	VERB
eurjchem-2615	110	13	where	where	SCONJ
eurjchem-2615	110	14	rings	ring	NOUN
eurjchem-2615	110	15	d	d	NOUN
eurjchem-2615	110	16	and	and	CCONJ
eurjchem-2615	110	17	e	e	PROPN
eurjchem-2615	110	18	were	be	AUX
eurjchem-2615	110	19	substituted	substitute	VERB
eurjchem-2615	110	20	with	with	ADP
eurjchem-2615	110	21	a	a	DET
eurjchem-2615	110	22	1,2,3triazole	1,2,3triazole	NUM
eurjchem-2615	110	23	and	and	CCONJ
eurjchem-2615	110	24	aryl	aryl	NOUN
eurjchem-2615	110	25	system	system	NOUN
eurjchem-2615	110	26	.	.	PUNCT
eurjchem-2615	111	1	the	the	DET
eurjchem-2615	111	2	resulting	result	VERB
eurjchem-2615	111	3	1,2,3	1,2,3	NUM
eurjchem-2615	111	4	-	-	ADJ
eurjchem-2615	111	5	triazole	triazole	ADJ
eurjchem-2615	111	6	-	-	PUNCT
eurjchem-2615	111	7	imidazooxazole	imidazooxazole	NOUN
eurjchem-2615	111	8	hybrid	hybrid	NOUN
eurjchem-2615	111	9	compound	compound	NOUN
eurjchem-2615	111	10	showed	show	VERB
eurjchem-2615	111	11	significant	significant	ADJ
eurjchem-2615	111	12	antitubercular	antitubercular	ADJ
eurjchem-2615	111	13	activity	activity	NOUN
eurjchem-2615	111	14	against	against	ADP
eurjchem-2615	111	15	mtb	mtb	NOUN
eurjchem-2615	111	16	h37rv	h37rv	PROPN
eurjchem-2615	111	17	with	with	ADP
eurjchem-2615	111	18	mic	mic	ADJ
eurjchem-2615	111	19	values	value	NOUN
eurjchem-2615	111	20	ranging	range	VERB
eurjchem-2615	111	21	from	from	ADP
eurjchem-2615	111	22	0.23	0.23	NUM
eurjchem-2615	111	23	to	to	ADP
eurjchem-2615	111	24	8.58	8.58	NUM
eurjchem-2615	111	25	μm	μm	NOUN
eurjchem-2615	112	1	[	[	X
eurjchem-2615	112	2	53	53	NUM
eurjchem-2615	112	3	]	]	PUNCT
eurjchem-2615	112	4	.	.	PUNCT
eurjchem-2615	113	1	similarly	similarly	ADV
eurjchem-2615	113	2	,	,	PUNCT
eurjchem-2615	113	3	the	the	DET
eurjchem-2615	113	4	1	1	NUM
eurjchem-2615	113	5	,	,	PUNCT
eurjchem-2615	113	6	2	2	NUM
eurjchem-2615	113	7	,	,	PUNCT
eurjchem-2615	113	8	3	3	NUM
eurjchem-2615	113	9	-	-	PUNCT
eurjchem-2615	113	10	triazole	triazole	NOUN
eurjchem-2615	113	11	-	-	PUNCT
eurjchem-2615	113	12	imidazo[2	imidazo[2	NOUN
eurjchem-2615	113	13	,	,	PUNCT
eurjchem-2615	113	14	1	1	NUM
eurjchem-2615	113	15	-	-	PUNCT
eurjchem-2615	113	16	b][1	b][1	NOUN
eurjchem-2615	113	17	,	,	PUNCT
eurjchem-2615	113	18	3	3	NUM
eurjchem-2615	113	19	,	,	PUNCT
eurjchem-2615	113	20	4]thiadiazole	4]thiadiazole	NOUN
eurjchem-2615	113	21	hybrids	hybrid	NOUN
eurjchem-2615	113	22	demonstrated	demonstrate	VERB
eurjchem-2615	113	23	notable	notable	ADJ
eurjchem-2615	113	24	antitubercular	antitubercular	ADJ
eurjchem-2615	113	25	activity	activity	NOUN
eurjchem-2615	113	26	against	against	ADP
eurjchem-2615	113	27	mtb	mtb	NOUN
eurjchem-2615	113	28	-	-	PUNCT
eurjchem-2615	113	29	h37rv	h37rv	PROPN
eurjchem-2615	113	30	(	(	PUNCT
eurjchem-2615	113	31	atcc27294	atcc27294	PROPN
eurjchem-2615	113	32	)	)	PUNCT
eurjchem-2615	113	33	,	,	PUNCT
eurjchem-2615	113	34	with	with	ADP
eurjchem-2615	113	35	mic	mic	ADJ
eurjchem-2615	113	36	values	value	NOUN
eurjchem-2615	113	37	ranging	range	VERB
eurjchem-2615	113	38	from	from	ADP
eurjchem-2615	113	39	3.12	3.12	NUM
eurjchem-2615	113	40	to	to	ADP
eurjchem-2615	113	41	50.0	50.0	NUM
eurjchem-2615	113	42	μg	μg	NOUN
eurjchem-2615	113	43	/	/	SYM
eurjchem-2615	113	44	ml	ml	PROPN
eurjchem-2615	113	45	.	.	PUNCT
eurjchem-2615	114	1	zimo	zimo	VERB
eurjchem-2615	114	2	and	and	CCONJ
eurjchem-2615	114	3	coghi	coghi	PROPN
eurjchem-2615	114	4	/	/	SYM
eurjchem-2615	114	5	european	european	PROPN
eurjchem-2615	114	6	journal	journal	PROPN
eurjchem-2615	114	7	of	of	ADP
eurjchem-2615	114	8	chemistry	chemistry	NOUN
eurjchem-2615	114	9	16	16	NUM
eurjchem-2615	114	10	(	(	PUNCT
eurjchem-2615	114	11	1	1	NUM
eurjchem-2615	114	12	)	)	PUNCT
eurjchem-2615	114	13	(	(	PUNCT
eurjchem-2615	114	14	2025	2025	NUM
eurjchem-2615	114	15	)	)	PUNCT
eurjchem-2615	114	16	83	83	NUM
eurjchem-2615	114	17	-	-	SYM
eurjchem-2615	114	18	96	96	NUM
eurjchem-2615	114	19	87	87	NUM
eurjchem-2615	114	20	2025	2025	NUM
eurjchem-2615	114	21	–	–	PUNCT
eurjchem-2615	114	22	european	european	ADJ
eurjchem-2615	114	23	journal	journal	NOUN
eurjchem-2615	114	24	of	of	ADP
eurjchem-2615	114	25	chemistry	chemistry	NOUN
eurjchem-2615	114	26	–	–	PUNCT
eurjchem-2615	114	27	cc	cc	NOUN
eurjchem-2615	114	28	by	by	ADP
eurjchem-2615	114	29	nc	nc	PROPN
eurjchem-2615	114	30	–	–	PUNCT
eurjchem-2615	114	31	doi	doi	NOUN
eurjchem-2615	114	32	:	:	PUNCT
eurjchem-2615	114	33	10.5155	10.5155	NUM
eurjchem-2615	114	34	/	/	SYM
eurjchem-2615	114	35	eurjchem.16.1.83	eurjchem.16.1.83	ADJ
eurjchem-2615	114	36	-	-	PUNCT
eurjchem-2615	114	37	96.2615	96.2615	NUM
eurjchem-2615	114	38	figure	figure	NOUN
eurjchem-2615	114	39	4	4	NUM
eurjchem-2615	114	40	.	.	PUNCT
eurjchem-2615	114	41	structure	structure	NOUN
eurjchem-2615	114	42	of	of	ADP
eurjchem-2615	114	43	some	some	DET
eurjchem-2615	114	44	1,2,3	1,2,3	NUM
eurjchem-2615	114	45	-	-	PUNCT
eurjchem-2615	114	46	triazole	triazole	ADJ
eurjchem-2615	114	47	-	-	PUNCT
eurjchem-2615	114	48	azole	azole	NOUN
eurjchem-2615	114	49	hybrids	hybrid	NOUN
eurjchem-2615	114	50	(	(	PUNCT
eurjchem-2615	114	51	1a	1a	X
eurjchem-2615	114	52	-	-	PUNCT
eurjchem-2615	114	53	g	g	NOUN
eurjchem-2615	114	54	)	)	PUNCT
eurjchem-2615	114	55	,	,	PUNCT
eurjchem-2615	114	56	2a	2a	NUM
eurjchem-2615	114	57	and	and	CCONJ
eurjchem-2615	114	58	2b	2b	NOUN
eurjchem-2615	114	59	,	,	PUNCT
eurjchem-2615	114	60	3	3	NUM
eurjchem-2615	114	61	and	and	CCONJ
eurjchem-2615	114	62	4	4	NUM
eurjchem-2615	114	63	with	with	ADP
eurjchem-2615	114	64	antitubercular	antitubercular	ADJ
eurjchem-2615	114	65	activity	activity	NOUN
eurjchem-2615	114	66	.	.	PUNCT
eurjchem-2615	115	1	o	o	NOUN
eurjchem-2615	116	1	oo	oo	INTJ
eurjchem-2615	116	2	n	n	CCONJ
eurjchem-2615	116	3	n	n	CCONJ
eurjchem-2615	116	4	n	n	NOUN
eurjchem-2615	116	5	o	o	NOUN
eurjchem-2615	116	6	o	o	X
eurjchem-2615	116	7	r	r	NOUN
eurjchem-2615	116	8	5	5	NUM
eurjchem-2615	116	9	5a	5a	NUM
eurjchem-2615	116	10	:	:	PUNCT
eurjchem-2615	116	11	r	r	NOUN
eurjchem-2615	116	12	=	=	SYM
eurjchem-2615	116	13	c6	c6	NOUN
eurjchem-2615	116	14	-	-	PUNCT
eurjchem-2615	116	15	cl	cl	NOUN
eurjchem-2615	116	16	5b	5b	NUM
eurjchem-2615	116	17	:	:	PUNCT
eurjchem-2615	117	1	r	r	X
eurjchem-2615	117	2	=	=	SYM
eurjchem-2615	117	3	c7	c7	NOUN
eurjchem-2615	117	4	-	-	PUNCT
eurjchem-2615	117	5	cl	cl	NOUN
eurjchem-2615	117	6	5c	5c	NOUN
eurjchem-2615	117	7	:	:	PUNCT
eurjchem-2615	117	8	r	r	X
eurjchem-2615	117	9	=	=	NOUN
eurjchem-2615	117	10	benzo	benzo	NOUN
eurjchem-2615	117	11	o	o	NOUN
eurjchem-2615	117	12	or1	or1	PROPN
eurjchem-2615	117	13	n	n	CCONJ
eurjchem-2615	117	14	n	n	CCONJ
eurjchem-2615	117	15	n	n	NOUN
eurjchem-2615	117	16	o	o	NOUN
eurjchem-2615	117	17	r	r	NOUN
eurjchem-2615	117	18	6	6	NUM
eurjchem-2615	117	19	6a	6a	NOUN
eurjchem-2615	117	20	:	:	PUNCT
eurjchem-2615	117	21	r=4	r=4	PROPN
eurjchem-2615	117	22	-	-	PUNCT
eurjchem-2615	117	23	br	br	ADP
eurjchem-2615	117	24	r1=7	r1=7	PROPN
eurjchem-2615	117	25	-	-	PUNCT
eurjchem-2615	117	26	ch3	ch3	PROPN
eurjchem-2615	117	27	6b	6b	NOUN
eurjchem-2615	117	28	:	:	PUNCT
eurjchem-2615	117	29	r=4	r=4	NOUN
eurjchem-2615	117	30	-	-	PUNCT
eurjchem-2615	117	31	br	br	ADP
eurjchem-2615	117	32	r1=6	r1=6	PROPN
eurjchem-2615	117	33	-	-	PUNCT
eurjchem-2615	117	34	ch3	ch3	PROPN
eurjchem-2615	117	35	o	o	NOUN
eurjchem-2615	117	36	o	o	NOUN
eurjchem-2615	117	37	r	r	NOUN
eurjchem-2615	117	38	n	n	CCONJ
eurjchem-2615	117	39	n	n	CCONJ
eurjchem-2615	117	40	n	n	NOUN
eurjchem-2615	117	41	o	o	NOUN
eurjchem-2615	118	1	o	o	X
eurjchem-2615	118	2	o	o	X
eurjchem-2615	118	3	r	r	NOUN
eurjchem-2615	118	4	n	n	NOUN
eurjchem-2615	118	5	nn	nn	NOUN
eurjchem-2615	118	6	o	o	NOUN
eurjchem-2615	118	7	7	7	NUM
eurjchem-2615	118	8	7a	7a	NUM
eurjchem-2615	118	9	:	:	PUNCT
eurjchem-2615	118	10	r=6	r=6	PROPN
eurjchem-2615	118	11	-	-	PUNCT
eurjchem-2615	118	12	ch3	ch3	PROPN
eurjchem-2615	118	13	7b	7b	PROPN
eurjchem-2615	118	14	:	:	PUNCT
eurjchem-2615	118	15	r=7	r=7	PROPN
eurjchem-2615	118	16	-	-	PUNCT
eurjchem-2615	118	17	ch3	ch3	ADJ
eurjchem-2615	118	18	figure	figure	NOUN
eurjchem-2615	118	19	5	5	NUM
eurjchem-2615	118	20	.	.	PUNCT
eurjchem-2615	118	21	structures	structure	NOUN
eurjchem-2615	118	22	of	of	ADP
eurjchem-2615	118	23	some	some	DET
eurjchem-2615	118	24	1,2,3	1,2,3	NUM
eurjchem-2615	118	25	-	-	PUNCT
eurjchem-2615	118	26	triazole	triazole	ADJ
eurjchem-2615	118	27	-	-	PUNCT
eurjchem-2615	118	28	coumarin	coumarin	NOUN
eurjchem-2615	118	29	hybrids	hybrid	NOUN
eurjchem-2615	118	30	(	(	PUNCT
eurjchem-2615	118	31	5a	5a	NUM
eurjchem-2615	118	32	-	-	SYM
eurjchem-2615	118	33	c	c	NOUN
eurjchem-2615	118	34	,	,	PUNCT
eurjchem-2615	118	35	6a	6a	NOUN
eurjchem-2615	118	36	-	-	PUNCT
eurjchem-2615	118	37	b	b	NOUN
eurjchem-2615	118	38	and	and	CCONJ
eurjchem-2615	118	39	7a	7a	NUM
eurjchem-2615	118	40	-	-	PUNCT
eurjchem-2615	118	41	b	b	NOUN
eurjchem-2615	118	42	)	)	PUNCT
eurjchem-2615	118	43	as	as	ADP
eurjchem-2615	118	44	potent	potent	ADJ
eurjchem-2615	118	45	antitubercular	antitubercular	ADJ
eurjchem-2615	118	46	agents	agent	NOUN
eurjchem-2615	118	47	.	.	PUNCT
eurjchem-2615	119	1	structural	structural	ADJ
eurjchem-2615	119	2	modification	modification	NOUN
eurjchem-2615	119	3	of	of	ADP
eurjchem-2615	119	4	the	the	DET
eurjchem-2615	119	5	delamanid	delamanid	NOUN
eurjchem-2615	119	6	,	,	PUNCT
eurjchem-2615	119	7	replacing	replace	VERB
eurjchem-2615	119	8	rings	ring	NOUN
eurjchem-2615	119	9	d	d	NOUN
eurjchem-2615	119	10	and	and	CCONJ
eurjchem-2615	119	11	e	e	NOUN
eurjchem-2615	119	12	with	with	ADP
eurjchem-2615	119	13	1,2,3	1,2,3	NOUN
eurjchem-2615	119	14	-	-	ADJ
eurjchem-2615	119	15	triazole	triazole	ADJ
eurjchem-2615	119	16	and	and	CCONJ
eurjchem-2615	119	17	aryl	aryl	NOUN
eurjchem-2615	119	18	systems	system	NOUN
eurjchem-2615	119	19	,	,	PUNCT
eurjchem-2615	119	20	yielded	yield	VERB
eurjchem-2615	119	21	active	active	ADJ
eurjchem-2615	119	22	hybrid	hybrid	ADJ
eurjchem-2615	119	23	1	1	NUM
eurjchem-2615	119	24	.	.	PUNCT
eurjchem-2615	120	1	the	the	DET
eurjchem-2615	120	2	triazole	triazole	ADJ
eurjchem-2615	120	3	group	group	NOUN
eurjchem-2615	120	4	showed	show	VERB
eurjchem-2615	120	5	optimal	optimal	ADJ
eurjchem-2615	120	6	activity	activity	NOUN
eurjchem-2615	120	7	at	at	ADP
eurjchem-2615	120	8	c	c	NOUN
eurjchem-2615	120	9	-	-	PUNCT
eurjchem-2615	120	10	ring	ring	NOUN
eurjchem-2615	120	11	positions	position	NOUN
eurjchem-2615	120	12	3	3	NUM
eurjchem-2615	120	13	or	or	CCONJ
eurjchem-2615	120	14	4	4	NUM
eurjchem-2615	120	15	,	,	PUNCT
eurjchem-2615	120	16	with	with	ADP
eurjchem-2615	120	17	-f	-f	NUM
eurjchem-2615	120	18	or	or	CCONJ
eurjchem-2615	120	19	-ocf3	-ocf3	PROPN
eurjchem-2615	120	20	substituents	substituent	NOUN
eurjchem-2615	120	21	enhancing	enhance	VERB
eurjchem-2615	120	22	potency	potency	NOUN
eurjchem-2615	120	23	.	.	PUNCT
eurjchem-2615	121	1	the	the	DET
eurjchem-2615	121	2	lead	lead	NOUN
eurjchem-2615	121	3	compound	compound	NOUN
eurjchem-2615	121	4	1a	1a	PROPN
eurjchem-2615	121	5	demonstrated	demonstrate	VERB
eurjchem-2615	121	6	strong	strong	ADJ
eurjchem-2615	121	7	in	in	ADP
eurjchem-2615	121	8	vivo	vivo	ADJ
eurjchem-2615	121	9	efficacy	efficacy	NOUN
eurjchem-2615	121	10	and	and	CCONJ
eurjchem-2615	121	11	synergy	synergy	NOUN
eurjchem-2615	121	12	with	with	ADP
eurjchem-2615	121	13	first	first	ADJ
eurjchem-2615	121	14	-	-	PUNCT
eurjchem-2615	121	15	line	line	NOUN
eurjchem-2615	121	16	tb	tb	ADP
eurjchem-2615	121	17	drugs	drug	NOUN
eurjchem-2615	121	18	[	[	X
eurjchem-2615	121	19	53	53	NUM
eurjchem-2615	121	20	]	]	PUNCT
eurjchem-2615	121	21	.	.	PUNCT
eurjchem-2615	122	1	two	two	NUM
eurjchem-2615	122	2	compounds	compound	NOUN
eurjchem-2615	122	3	in	in	ADP
eurjchem-2615	122	4	particular	particular	ADJ
eurjchem-2615	122	5	,	,	PUNCT
eurjchem-2615	122	6	hybrids	hybrid	NOUN
eurjchem-2615	122	7	2a	2a	NUM
eurjchem-2615	122	8	and	and	CCONJ
eurjchem-2615	122	9	2b	2b	NOUN
eurjchem-2615	122	10	,	,	PUNCT
eurjchem-2615	122	11	showed	show	VERB
eurjchem-2615	122	12	potency	potency	NOUN
eurjchem-2615	122	13	equivalent	equivalent	ADJ
eurjchem-2615	122	14	to	to	ADP
eurjchem-2615	122	15	the	the	DET
eurjchem-2615	122	16	first	first	ADJ
eurjchem-2615	122	17	-	-	PUNCT
eurjchem-2615	122	18	line	line	NOUN
eurjchem-2615	122	19	drug	drug	NOUN
eurjchem-2615	122	20	ethambutol	ethambutol	NOUN
eurjchem-2615	122	21	,	,	PUNCT
eurjchem-2615	122	22	all	all	PRON
eurjchem-2615	122	23	with	with	ADP
eurjchem-2615	122	24	mic	mic	ADJ
eurjchem-2615	122	25	values	value	NOUN
eurjchem-2615	122	26	of	of	ADP
eurjchem-2615	122	27	3.12	3.12	NUM
eurjchem-2615	122	28	μg	μg	NOUN
eurjchem-2615	122	29	/	/	SYM
eurjchem-2615	122	30	ml	ml	NOUN
eurjchem-2615	122	31	.	.	PUNCT
eurjchem-2615	122	32	structure	structure	NOUN
eurjchem-2615	122	33	-	-	PUNCT
eurjchem-2615	122	34	activity	activity	NOUN
eurjchem-2615	122	35	relationship	relationship	NOUN
eurjchem-2615	122	36	(	(	PUNCT
eurjchem-2615	122	37	sar	sar	PROPN
eurjchem-2615	122	38	)	)	PUNCT
eurjchem-2615	122	39	studies	study	NOUN
eurjchem-2615	122	40	revealed	reveal	VERB
eurjchem-2615	122	41	that	that	SCONJ
eurjchem-2615	122	42	biological	biological	ADJ
eurjchem-2615	122	43	activity	activity	NOUN
eurjchem-2615	122	44	could	could	AUX
eurjchem-2615	122	45	be	be	AUX
eurjchem-2615	122	46	optimized	optimize	VERB
eurjchem-2615	122	47	through	through	ADP
eurjchem-2615	122	48	appropriate	appropriate	ADJ
eurjchem-2615	122	49	modification	modification	NOUN
eurjchem-2615	122	50	of	of	ADP
eurjchem-2615	122	51	substituents	substituent	NOUN
eurjchem-2615	122	52	r1	r1	NOUN
eurjchem-2615	122	53	and	and	CCONJ
eurjchem-2615	122	54	r2	r2	PROPN
eurjchem-2615	122	55	on	on	ADP
eurjchem-2615	122	56	the	the	DET
eurjchem-2615	122	57	hybrid	hybrid	ADJ
eurjchem-2615	122	58	scaffold	scaffold	NOUN
eurjchem-2615	122	59	.	.	PUNCT
eurjchem-2615	123	1	importantly	importantly	ADV
eurjchem-2615	123	2	,	,	PUNCT
eurjchem-2615	123	3	cytotoxicity	cytotoxicity	NOUN
eurjchem-2615	123	4	studies	study	NOUN
eurjchem-2615	123	5	of	of	ADP
eurjchem-2615	123	6	hybrids	hybrid	NOUN
eurjchem-2615	123	7	2a	2a	NUM
eurjchem-2615	123	8	and	and	CCONJ
eurjchem-2615	123	9	2b	2b	NUM
eurjchem-2615	123	10	using	use	VERB
eurjchem-2615	123	11	nih	nih	PROPN
eurjchem-2615	123	12	3t3	3t3	NUM
eurjchem-2615	123	13	mouse	mouse	NOUN
eurjchem-2615	123	14	embryonic	embryonic	ADJ
eurjchem-2615	123	15	fibroblasts	fibroblast	NOUN
eurjchem-2615	123	16	demonstrated	demonstrate	VERB
eurjchem-2615	123	17	their	their	PRON
eurjchem-2615	123	18	safety	safety	NOUN
eurjchem-2615	123	19	profile	profile	NOUN
eurjchem-2615	123	20	,	,	PUNCT
eurjchem-2615	123	21	showing	show	VERB
eurjchem-2615	123	22	no	no	DET
eurjchem-2615	123	23	toxicity	toxicity	NOUN
eurjchem-2615	123	24	to	to	ADP
eurjchem-2615	123	25	normal	normal	ADJ
eurjchem-2615	123	26	cells	cell	NOUN
eurjchem-2615	123	27	[	[	X
eurjchem-2615	123	28	54	54	NUM
eurjchem-2615	123	29	]	]	PUNCT
eurjchem-2615	123	30	.	.	PUNCT
eurjchem-2615	124	1	the	the	DET
eurjchem-2615	124	2	modification	modification	NOUN
eurjchem-2615	124	3	of	of	ADP
eurjchem-2615	124	4	zolpidem	zolpidem	PROPN
eurjchem-2615	124	5	yielded	yield	VERB
eurjchem-2615	124	6	hybrid	hybrid	ADJ
eurjchem-2615	124	7	compounds	compound	NOUN
eurjchem-2615	124	8	3	3	NUM
eurjchem-2615	124	9	,	,	PUNCT
eurjchem-2615	124	10	incorporating	incorporate	VERB
eurjchem-2615	124	11	1,2,3	1,2,3	NUM
eurjchem-2615	124	12	-	-	NOUN
eurjchem-2615	124	13	triazole	triazole	ADJ
eurjchem-2615	124	14	and	and	CCONJ
eurjchem-2615	124	15	imidazo[1,2	imidazo[1,2	NOUN
eurjchem-2615	124	16	-	-	PUNCT
eurjchem-2615	124	17	a	a	NOUN
eurjchem-2615	124	18	]	]	X
eurjchem-2615	124	19	pyridine	pyridine	NOUN
eurjchem-2615	124	20	scaffolds	scaffold	NOUN
eurjchem-2615	124	21	.	.	PUNCT
eurjchem-2615	125	1	compounds	compound	NOUN
eurjchem-2615	125	2	3	3	NUM
eurjchem-2615	125	3	showed	show	VERB
eurjchem-2615	125	4	improved	improve	VERB
eurjchem-2615	125	5	anti	anti	ADJ
eurjchem-2615	125	6	-	-	ADJ
eurjchem-2615	125	7	tb	tb	ADJ
eurjchem-2615	125	8	activity	activity	NOUN
eurjchem-2615	125	9	(	(	PUNCT
eurjchem-2615	125	10	mic	mic	ADJ
eurjchem-2615	125	11	1.56	1.56	NUM
eurjchem-2615	125	12	μg	μg	NOUN
eurjchem-2615	125	13	/	/	SYM
eurjchem-2615	125	14	ml	ml	NOUN
eurjchem-2615	125	15	)	)	PUNCT
eurjchem-2615	125	16	versus	versus	ADP
eurjchem-2615	125	17	zolpidem	zolpidem	PROPN
eurjchem-2615	125	18	and	and	CCONJ
eurjchem-2615	125	19	pyrazinamide	pyrazinamide	NOUN
eurjchem-2615	125	20	(	(	PUNCT
eurjchem-2615	125	21	both	both	CCONJ
eurjchem-2615	125	22	mic	mic	ADJ
eurjchem-2615	125	23	3.12	3.12	NUM
eurjchem-2615	125	24	μg	μg	NOUN
eurjchem-2615	125	25	/	/	SYM
eurjchem-2615	125	26	ml	ml	NOUN
eurjchem-2615	125	27	)	)	PUNCT
eurjchem-2615	125	28	,	,	PUNCT
eurjchem-2615	125	29	with	with	ADP
eurjchem-2615	125	30	molecular	molecular	ADJ
eurjchem-2615	125	31	docking	docking	NOUN
eurjchem-2615	125	32	confirming	confirm	VERB
eurjchem-2615	125	33	inha	inha	NOUN
eurjchem-2615	125	34	binding	bind	VERB
eurjchem-2615	125	35	through	through	ADP
eurjchem-2615	125	36	tyr158	tyr158	PROPN
eurjchem-2615	125	37	[	[	X
eurjchem-2615	125	38	55	55	NUM
eurjchem-2615	125	39	]	]	PUNCT
eurjchem-2615	125	40	.	.	PUNCT
eurjchem-2615	126	1	pyrazolo[4,3	pyrazolo[4,3	ADJ
eurjchem-2615	126	2	-	-	ADJ
eurjchem-2615	126	3	c]pyridine5(4h)-carboxamide	c]pyridine5(4h)-carboxamide	ADJ
eurjchem-2615	126	4	hybrids	hybrid	NOUN
eurjchem-2615	126	5	4	4	NUM
eurjchem-2615	126	6	showed	show	VERB
eurjchem-2615	126	7	activity	activity	NOUN
eurjchem-2615	126	8	against	against	ADP
eurjchem-2615	126	9	mtb	mtb	NOUN
eurjchem-2615	126	10	strains	strain	NOUN
eurjchem-2615	126	11	(	(	PUNCT
eurjchem-2615	126	12	mic	mic	ADJ
eurjchem-2615	126	13	24.72	24.72	NUM
eurjchem-2615	126	14	-	-	SYM
eurjchem-2615	126	15	200	200	NUM
eurjchem-2615	126	16	μm	μm	NUM
eurjchem-2615	126	17	)	)	PUNCT
eurjchem-2615	126	18	,	,	PUNCT
eurjchem-2615	126	19	including	include	VERB
eurjchem-2615	126	20	drug	drug	NOUN
eurjchem-2615	126	21	resistant	resistant	ADJ
eurjchem-2615	126	22	spec	spec	NOUN
eurjchem-2615	126	23	.	.	PUNCT
eurjchem-2615	127	1	210	210	NUM
eurjchem-2615	127	2	and	and	CCONJ
eurjchem-2615	127	3	sensitive	sensitive	ADJ
eurjchem-2615	127	4	spec	spec	NOUN
eurjchem-2615	127	5	.	.	PUNCT
eurjchem-2615	128	1	192	192	NUM
eurjchem-2615	128	2	.	.	PUNCT
eurjchem-2615	129	1	the	the	DET
eurjchem-2615	129	2	lead	lead	NOUN
eurjchem-2615	129	3	compound	compound	NOUN
eurjchem-2615	129	4	4	4	NUM
eurjchem-2615	129	5	demonstrated	demonstrate	VERB
eurjchem-2615	129	6	88	88	NUM
eurjchem-2615	129	7	zimo	zimo	ADJ
eurjchem-2615	129	8	and	and	CCONJ
eurjchem-2615	129	9	coghi	coghi	PROPN
eurjchem-2615	129	10	/	/	SYM
eurjchem-2615	129	11	european	european	PROPN
eurjchem-2615	129	12	journal	journal	PROPN
eurjchem-2615	129	13	of	of	ADP
eurjchem-2615	129	14	chemistry	chemistry	NOUN
eurjchem-2615	129	15	16	16	NUM
eurjchem-2615	129	16	(	(	PUNCT
eurjchem-2615	129	17	1	1	NUM
eurjchem-2615	129	18	)	)	PUNCT
eurjchem-2615	129	19	(	(	PUNCT
eurjchem-2615	129	20	2025	2025	NUM
eurjchem-2615	129	21	)	)	PUNCT
eurjchem-2615	129	22	83	83	NUM
eurjchem-2615	129	23	-	-	SYM
eurjchem-2615	129	24	96	96	NUM
eurjchem-2615	129	25	2025	2025	NUM
eurjchem-2615	129	26	–	–	PUNCT
eurjchem-2615	129	27	european	european	ADJ
eurjchem-2615	129	28	journal	journal	NOUN
eurjchem-2615	129	29	of	of	ADP
eurjchem-2615	129	30	chemistry	chemistry	NOUN
eurjchem-2615	129	31	–	–	PUNCT
eurjchem-2615	129	32	cc	cc	NOUN
eurjchem-2615	129	33	by	by	ADP
eurjchem-2615	129	34	nc	nc	PROPN
eurjchem-2615	129	35	–	–	PUNCT
eurjchem-2615	129	36	doi	doi	NOUN
eurjchem-2615	129	37	:	:	PUNCT
eurjchem-2615	129	38	10.5155	10.5155	NUM
eurjchem-2615	129	39	/	/	SYM
eurjchem-2615	129	40	eurjchem.16.1.83	eurjchem.16.1.83	PROPN
eurjchem-2615	129	41	-	-	PUNCT
eurjchem-2615	129	42	96.2615	96.2615	NUM
eurjchem-2615	129	43	n	n	NUM
eurjchem-2615	129	44	o	o	PROPN
eurjchem-2615	129	45	nh	nh	PROPN
eurjchem-2615	129	46	n	n	CCONJ
eurjchem-2615	129	47	h	h	NOUN
eurjchem-2615	129	48	cl	cl	NOUN
eurjchem-2615	130	1	cl	cl	NOUN
eurjchem-2615	131	1	o	o	NOUN
eurjchem-2615	131	2	n	n	CCONJ
eurjchem-2615	131	3	nn	nn	INTJ
eurjchem-2615	131	4	cl	cl	NOUN
eurjchem-2615	131	5	8	8	NUM
eurjchem-2615	131	6	n	n	NUM
eurjchem-2615	131	7	n	n	NOUN
eurjchem-2615	131	8	h	h	NOUN
eurjchem-2615	131	9	o	o	NOUN
eurjchem-2615	131	10	n	n	CCONJ
eurjchem-2615	131	11	n	n	CCONJ
eurjchem-2615	131	12	nn	nn	NOUN
eurjchem-2615	131	13	r	r	NOUN
eurjchem-2615	131	14	9	9	NUM
eurjchem-2615	131	15	9a	9a	NOUN
eurjchem-2615	131	16	:	:	PUNCT
eurjchem-2615	131	17	r=4	r=4	NOUN
eurjchem-2615	131	18	-	-	NOUN
eurjchem-2615	131	19	cl	cl	ADJ
eurjchem-2615	131	20	;	;	PUNCT
eurjchem-2615	131	21	7b	7b	NUM
eurjchem-2615	131	22	:	:	PUNCT
eurjchem-2615	131	23	r=3	r=3	NOUN
eurjchem-2615	131	24	-	-	PUNCT
eurjchem-2615	131	25	cl	cl	NOUN
eurjchem-2615	131	26	;	;	PUNCT
eurjchem-2615	131	27	9c	9c	NUM
eurjchem-2615	131	28	:	:	PUNCT
eurjchem-2615	131	29	r=3	r=3	VERB
eurjchem-2615	131	30	-	-	PUNCT
eurjchem-2615	131	31	me	i	PRON
eurjchem-2615	131	32	;	;	PUNCT
eurjchem-2615	131	33	7d	7d	NUM
eurjchem-2615	131	34	:	:	PUNCT
eurjchem-2615	131	35	r=4	r=4	PROPN
eurjchem-2615	131	36	-	-	NOUN
eurjchem-2615	131	37	no2	no2	NOUN
eurjchem-2615	131	38	9e	9e	NOUN
eurjchem-2615	131	39	:	:	PUNCT
eurjchem-2615	131	40	r=2	r=2	VERB
eurjchem-2615	131	41	-	-	PUNCT
eurjchem-2615	131	42	ome	ome	NOUN
eurjchem-2615	131	43	o2n	o2n	NOUN
eurjchem-2615	131	44	o	o	NOUN
eurjchem-2615	131	45	n	n	CCONJ
eurjchem-2615	131	46	n	n	CCONJ
eurjchem-2615	131	47	n	n	CCONJ
eurjchem-2615	131	48	n	n	ADP
eurjchem-2615	131	49	r	r	NOUN
eurjchem-2615	131	50	n	n	NUM
eurjchem-2615	131	51	h	h	NOUN
eurjchem-2615	131	52	o	o	NOUN
eurjchem-2615	131	53	n	n	CCONJ
eurjchem-2615	131	54	10	10	NUM
eurjchem-2615	131	55	n	n	NUM
eurjchem-2615	131	56	o	o	NOUN
eurjchem-2615	131	57	h	h	NOUN
eurjchem-2615	131	58	n	n	CCONJ
eurjchem-2615	131	59	n	n	NOUN
eurjchem-2615	131	60	o	o	NOUN
eurjchem-2615	131	61	n	n	CCONJ
eurjchem-2615	131	62	n	n	CCONJ
eurjchem-2615	131	63	n	n	NOUN
eurjchem-2615	131	64	r	r	NOUN
eurjchem-2615	131	65	r	r	NOUN
eurjchem-2615	131	66	=	=	PUNCT
eurjchem-2615	131	67	n	n	CCONJ
eurjchem-2615	131	68	-	-	PUNCT
eurjchem-2615	131	69	pr	pr	NOUN
eurjchem-2615	131	70	,	,	PUNCT
eurjchem-2615	131	71	i	i	PRON
eurjchem-2615	131	72	-	-	PUNCT
eurjchem-2615	131	73	pr	pr	NOUN
eurjchem-2615	131	74	,	,	PUNCT
eurjchem-2615	131	75	n	n	CCONJ
eurjchem-2615	131	76	-	-	PUNCT
eurjchem-2615	131	77	bu	bu	ADJ
eurjchem-2615	131	78	11	11	NUM
eurjchem-2615	131	79	figure	figure	NOUN
eurjchem-2615	131	80	6	6	NUM
eurjchem-2615	131	81	.	.	PUNCT
eurjchem-2615	131	82	structures	structure	NOUN
eurjchem-2615	131	83	of	of	ADP
eurjchem-2615	131	84	inh-1,2,3	inh-1,2,3	ADJ
eurjchem-2615	131	85	-	-	ADJ
eurjchem-2615	131	86	triazole	triazole	ADJ
eurjchem-2615	131	87	hybrids	hybrid	NOUN
eurjchem-2615	131	88	8	8	NUM
eurjchem-2615	131	89	,	,	PUNCT
eurjchem-2615	131	90	9	9	NUM
eurjchem-2615	131	91	,	,	PUNCT
eurjchem-2615	131	92	10	10	NUM
eurjchem-2615	131	93	and	and	CCONJ
eurjchem-2615	131	94	11	11	NUM
eurjchem-2615	131	95	as	as	ADP
eurjchem-2615	131	96	potential	potential	ADJ
eurjchem-2615	131	97	antitubercular	antitubercular	ADJ
eurjchem-2615	131	98	agents	agent	NOUN
eurjchem-2615	131	99	.	.	PUNCT
eurjchem-2615	132	1	potent	potent	ADJ
eurjchem-2615	132	2	mtb	mtb	NOUN
eurjchem-2615	132	3	-	-	PUNCT
eurjchem-2615	132	4	ps	ps	NOUN
eurjchem-2615	132	5	inhibition	inhibition	NOUN
eurjchem-2615	132	6	(	(	PUNCT
eurjchem-2615	132	7	ic50	ic50	PROPN
eurjchem-2615	132	8	1.01	1.01	NUM
eurjchem-2615	132	9	μm	μm	NOUN
eurjchem-2615	132	10	)	)	PUNCT
eurjchem-2615	132	11	,	,	PUNCT
eurjchem-2615	132	12	good	good	ADJ
eurjchem-2615	132	13	anti	anti	ADJ
eurjchem-2615	132	14	-	-	ADJ
eurjchem-2615	132	15	tb	tb	ADJ
eurjchem-2615	132	16	activity	activity	NOUN
eurjchem-2615	132	17	(	(	PUNCT
eurjchem-2615	132	18	mic	mic	ADJ
eurjchem-2615	132	19	24.72	24.72	NUM
eurjchem-2615	132	20	μm	μm	NOUN
eurjchem-2615	132	21	)	)	PUNCT
eurjchem-2615	132	22	,	,	PUNCT
eurjchem-2615	132	23	and	and	CCONJ
eurjchem-2615	132	24	low	low	ADJ
eurjchem-2615	132	25	toxicity	toxicity	NOUN
eurjchem-2615	132	26	to	to	ADP
eurjchem-2615	132	27	raw	raw	ADJ
eurjchem-2615	132	28	264.7	264.7	NUM
eurjchem-2615	132	29	cells	cell	NOUN
eurjchem-2615	132	30	[	[	X
eurjchem-2615	132	31	56	56	NUM
eurjchem-2615	132	32	]	]	PUNCT
eurjchem-2615	132	33	.	.	PUNCT
eurjchem-2615	133	1	4.2	4.2	NUM
eurjchem-2615	133	2	.	.	PUNCT
eurjchem-2615	133	3	coumarin	coumarin	NOUN
eurjchem-2615	133	4	/	/	SYM
eurjchem-2615	133	5	chromene-1,2,3	chromene-1,2,3	NOUN
eurjchem-2615	133	6	-	-	PUNCT
eurjchem-2615	133	7	triazole	triazole	ADJ
eurjchem-2615	133	8	hybrids	hybrid	NOUN
eurjchem-2615	133	9	coumarin	coumarin	NOUN
eurjchem-2615	133	10	,	,	PUNCT
eurjchem-2615	133	11	structurally	structurally	ADV
eurjchem-2615	133	12	known	know	VERB
eurjchem-2615	133	13	as	as	ADP
eurjchem-2615	133	14	2h-1	2h-1	NUM
eurjchem-2615	133	15	-	-	PUNCT
eurjchem-2615	133	16	benzopyran-2	benzopyran-2	NOUN
eurjchem-2615	133	17	-	-	PUNCT
eurjchem-2615	133	18	one	one	NUM
eurjchem-2615	133	19	,	,	PUNCT
eurjchem-2615	133	20	represents	represent	VERB
eurjchem-2615	133	21	a	a	DET
eurjchem-2615	133	22	key	key	ADJ
eurjchem-2615	133	23	scaffold	scaffold	NOUN
eurjchem-2615	133	24	found	find	VERB
eurjchem-2615	133	25	in	in	ADP
eurjchem-2615	133	26	numerous	numerous	ADJ
eurjchem-2615	133	27	complex	complex	ADJ
eurjchem-2615	133	28	natural	natural	ADJ
eurjchem-2615	133	29	products	product	NOUN
eurjchem-2615	133	30	that	that	PRON
eurjchem-2615	133	31	exhibit	exhibit	VERB
eurjchem-2615	133	32	various	various	ADJ
eurjchem-2615	133	33	biological	biological	ADJ
eurjchem-2615	133	34	activities	activity	NOUN
eurjchem-2615	133	35	[	[	X
eurjchem-2615	133	36	57	57	NUM
eurjchem-2615	133	37	]	]	PUNCT
eurjchem-2615	133	38	.	.	PUNCT
eurjchem-2615	134	1	the	the	DET
eurjchem-2615	134	2	strategy	strategy	NOUN
eurjchem-2615	134	3	of	of	ADP
eurjchem-2615	134	4	combining	combine	VERB
eurjchem-2615	134	5	the	the	DET
eurjchem-2615	134	6	coumarin	coumarin	NOUN
eurjchem-2615	134	7	framework	framework	NOUN
eurjchem-2615	134	8	with	with	ADP
eurjchem-2615	134	9	1,2,3triazole	1,2,3triazole	NUM
eurjchem-2615	134	10	heterocycles	heterocycle	NOUN
eurjchem-2615	134	11	through	through	ADP
eurjchem-2615	134	12	molecular	molecular	ADJ
eurjchem-2615	134	13	hybridization	hybridization	NOUN
eurjchem-2615	134	14	offers	offer	VERB
eurjchem-2615	134	15	the	the	DET
eurjchem-2615	134	16	potential	potential	NOUN
eurjchem-2615	134	17	to	to	PART
eurjchem-2615	134	18	develop	develop	VERB
eurjchem-2615	134	19	new	new	ADJ
eurjchem-2615	134	20	anti	anti	ADJ
eurjchem-2615	134	21	-	-	ADJ
eurjchem-2615	134	22	tb	tb	ADJ
eurjchem-2615	134	23	agents	agent	NOUN
eurjchem-2615	134	24	with	with	ADP
eurjchem-2615	134	25	enhanced	enhanced	ADJ
eurjchem-2615	134	26	efficacy	efficacy	NOUN
eurjchem-2615	134	27	and	and	CCONJ
eurjchem-2615	134	28	safety	safety	NOUN
eurjchem-2615	134	29	profiles	profile	NOUN
eurjchem-2615	134	30	(	(	PUNCT
eurjchem-2615	134	31	figure	figure	NOUN
eurjchem-2615	134	32	5	5	NUM
eurjchem-2615	134	33	)	)	PUNCT
eurjchem-2615	134	34	.	.	PUNCT
eurjchem-2615	135	1	for	for	ADP
eurjchem-2615	135	2	example	example	NOUN
eurjchem-2615	135	3	,	,	PUNCT
eurjchem-2615	135	4	1,4disubstituted	1,4disubstituted	NUM
eurjchem-2615	135	5	bis	bis	ADJ
eurjchem-2615	135	6	-	-	ADJ
eurjchem-2615	135	7	chromene-1,2,3	chromene-1,2,3	ADJ
eurjchem-2615	135	8	-	-	PUNCT
eurjchem-2615	135	9	triazole	triazole	NOUN
eurjchem-2615	135	10	hybrids	hybrid	NOUN
eurjchem-2615	135	11	5a	5a	NUM
eurjchem-2615	135	12	,	,	PUNCT
eurjchem-2615	135	13	5b	5b	NUM
eurjchem-2615	135	14	,	,	PUNCT
eurjchem-2615	135	15	and	and	CCONJ
eurjchem-2615	135	16	5c	5c	NUM
eurjchem-2615	135	17	(	(	PUNCT
eurjchem-2615	135	18	figure	figure	NOUN
eurjchem-2615	135	19	4	4	NUM
eurjchem-2615	135	20	)	)	PUNCT
eurjchem-2615	135	21	showed	show	VERB
eurjchem-2615	135	22	promising	promising	ADJ
eurjchem-2615	135	23	in	in	ADP
eurjchem-2615	135	24	vitro	vitro	X
eurjchem-2615	135	25	potency	potency	NOUN
eurjchem-2615	135	26	against	against	ADP
eurjchem-2615	135	27	the	the	DET
eurjchem-2615	135	28	mycobacterium	mycobacterium	NOUN
eurjchem-2615	135	29	tuberculosis	tuberculosis	NOUN
eurjchem-2615	135	30	h37rv	h37rv	PROPN
eurjchem-2615	135	31	strain	strain	NOUN
eurjchem-2615	135	32	with	with	ADP
eurjchem-2615	135	33	mic	mic	ADJ
eurjchem-2615	135	34	values	value	NOUN
eurjchem-2615	135	35	of	of	ADP
eurjchem-2615	135	36	6.25	6.25	NUM
eurjchem-2615	135	37	μg	μg	NOUN
eurjchem-2615	135	38	/	/	SYM
eurjchem-2615	135	39	ml	ml	NOUN
eurjchem-2615	135	40	,	,	PUNCT
eurjchem-2615	135	41	comparable	comparable	ADJ
eurjchem-2615	135	42	to	to	ADP
eurjchem-2615	135	43	the	the	DET
eurjchem-2615	135	44	reference	reference	NOUN
eurjchem-2615	135	45	drug	drug	NOUN
eurjchem-2615	135	46	streptomycin	streptomycin	PROPN
eurjchem-2615	135	47	(	(	PUNCT
eurjchem-2615	135	48	mic	mic	NOUN
eurjchem-2615	135	49	:	:	PUNCT
eurjchem-2615	135	50	6.25	6.25	NUM
eurjchem-2615	135	51	μg	μg	NOUN
eurjchem-2615	135	52	/	/	SYM
eurjchem-2615	135	53	ml	ml	NOUN
eurjchem-2615	135	54	)	)	PUNCT
eurjchem-2615	136	1	[	[	X
eurjchem-2615	136	2	58	58	NUM
eurjchem-2615	136	3	]	]	PUNCT
eurjchem-2615	136	4	.	.	PUNCT
eurjchem-2615	137	1	the	the	DET
eurjchem-2615	137	2	introduction	introduction	NOUN
eurjchem-2615	137	3	of	of	ADP
eurjchem-2615	137	4	benzo	benzo	PROPN
eurjchem-2615	137	5	and	and	CCONJ
eurjchem-2615	137	6	chloro	chloro	NOUN
eurjchem-2615	137	7	substituents	substituent	NOUN
eurjchem-2615	137	8	demonstrated	demonstrate	VERB
eurjchem-2615	137	9	enhanced	enhance	VERB
eurjchem-2615	137	10	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	137	11	activity	activity	NOUN
eurjchem-2615	137	12	.	.	PUNCT
eurjchem-2615	138	1	comparative	comparative	ADJ
eurjchem-2615	138	2	analysis	analysis	NOUN
eurjchem-2615	138	3	revealed	reveal	VERB
eurjchem-2615	138	4	that	that	SCONJ
eurjchem-2615	138	5	these	these	DET
eurjchem-2615	138	6	hybrids	hybrid	NOUN
eurjchem-2615	138	7	showed	show	VERB
eurjchem-2615	138	8	superior	superior	ADJ
eurjchem-2615	138	9	activity	activity	NOUN
eurjchem-2615	138	10	compared	compare	VERB
eurjchem-2615	138	11	to	to	ADP
eurjchem-2615	138	12	2h	2h	NUM
eurjchem-2615	138	13	-	-	PUNCT
eurjchem-2615	138	14	chromen-2	chromen-2	NUM
eurjchem-2615	138	15	-	-	PUNCT
eurjchem-2615	138	16	one	one	NUM
eurjchem-2615	138	17	compounds	compound	NOUN
eurjchem-2615	138	18	containing	contain	VERB
eurjchem-2615	138	19	hydrazone	hydrazone	NOUN
eurjchem-2615	138	20	units	unit	NOUN
eurjchem-2615	138	21	(	(	PUNCT
eurjchem-2615	138	22	mic	mic	ADJ
eurjchem-2615	138	23	:	:	PUNCT
eurjchem-2615	138	24	50	50	NUM
eurjchem-2615	138	25	-	-	SYM
eurjchem-2615	138	26	100	100	NUM
eurjchem-2615	138	27	μg	μg	NOUN
eurjchem-2615	138	28	/	/	SYM
eurjchem-2615	138	29	ml	ml	NOUN
eurjchem-2615	138	30	)	)	PUNCT
eurjchem-2615	138	31	and	and	CCONJ
eurjchem-2615	138	32	benzyl	benzyl	NOUN
eurjchem-2615	138	33	triazoles	triazole	NOUN
eurjchem-2615	138	34	(	(	PUNCT
eurjchem-2615	138	35	mic	mic	ADJ
eurjchem-2615	138	36	:	:	PUNCT
eurjchem-2615	138	37	16	16	NUM
eurjchem-2615	138	38	μg	μg	PROPN
eurjchem-2615	138	39	/	/	SYM
eurjchem-2615	138	40	ml	ml	NOUN
eurjchem-2615	138	41	)	)	PUNCT
eurjchem-2615	138	42	,	,	PUNCT
eurjchem-2615	138	43	validating	validate	VERB
eurjchem-2615	138	44	the	the	DET
eurjchem-2615	138	45	effectiveness	effectiveness	NOUN
eurjchem-2615	138	46	of	of	ADP
eurjchem-2615	138	47	this	this	DET
eurjchem-2615	138	48	molecular	molecular	ADJ
eurjchem-2615	138	49	hybridization	hybridization	NOUN
eurjchem-2615	138	50	strategy	strategy	NOUN
eurjchem-2615	138	51	for	for	ADP
eurjchem-2615	138	52	developing	develop	VERB
eurjchem-2615	138	53	potent	potent	ADJ
eurjchem-2615	138	54	anti	anti	ADJ
eurjchem-2615	138	55	-	-	ADJ
eurjchem-2615	138	56	tb	tb	ADJ
eurjchem-2615	138	57	agents	agent	NOUN
eurjchem-2615	138	58	.	.	PUNCT
eurjchem-2615	139	1	in	in	ADP
eurjchem-2615	139	2	particular	particular	ADJ
eurjchem-2615	139	3	,	,	PUNCT
eurjchem-2615	139	4	bis	bis	ADJ
eurjchem-2615	139	5	-	-	ADJ
eurjchem-2615	139	6	chromenyl	chromenyl	ADJ
eurjchem-2615	139	7	triazole	triazole	NOUN
eurjchem-2615	139	8	hybrids	hybrid	NOUN
eurjchem-2615	139	9	exhibited	exhibit	VERB
eurjchem-2615	139	10	significantly	significantly	ADV
eurjchem-2615	139	11	higher	high	ADJ
eurjchem-2615	139	12	potency	potency	NOUN
eurjchem-2615	139	13	(	(	PUNCT
eurjchem-2615	139	14	mic	mic	ADJ
eurjchem-2615	139	15	:	:	PUNCT
eurjchem-2615	139	16	0.2	0.2	NUM
eurjchem-2615	139	17	-	-	SYM
eurjchem-2615	139	18	12.5	12.5	NUM
eurjchem-2615	139	19	μg	μg	NOUN
eurjchem-2615	139	20	/	/	SYM
eurjchem-2615	139	21	ml	ml	NOUN
eurjchem-2615	139	22	)	)	PUNCT
eurjchem-2615	139	23	against	against	ADP
eurjchem-2615	139	24	mtb	mtb	NOUN
eurjchem-2615	139	25	h37rv	h37rv	PROPN
eurjchem-2615	139	26	compared	compare	VERB
eurjchem-2615	139	27	to	to	ADP
eurjchem-2615	139	28	their	their	PRON
eurjchem-2615	139	29	monochromenyl	monochromenyl	NOUN
eurjchem-2615	139	30	triazole	triazole	NOUN
eurjchem-2615	139	31	counterparts	counterpart	NOUN
eurjchem-2615	139	32	(	(	PUNCT
eurjchem-2615	139	33	mic	mic	ADJ
eurjchem-2615	139	34	:	:	PUNCT
eurjchem-2615	139	35	50	50	NUM
eurjchem-2615	139	36	-	-	SYM
eurjchem-2615	139	37	100	100	NUM
eurjchem-2615	139	38	μg	μg	NOUN
eurjchem-2615	139	39	/	/	SYM
eurjchem-2615	139	40	ml	ml	NOUN
eurjchem-2615	139	41	)	)	PUNCT
eurjchem-2615	139	42	,	,	PUNCT
eurjchem-2615	139	43	highlighting	highlight	VERB
eurjchem-2615	139	44	the	the	DET
eurjchem-2615	139	45	beneficial	beneficial	ADJ
eurjchem-2615	139	46	effect	effect	NOUN
eurjchem-2615	139	47	of	of	ADP
eurjchem-2615	139	48	incorporating	incorporate	VERB
eurjchem-2615	139	49	two	two	NUM
eurjchem-2615	139	50	triazole	triazole	ADJ
eurjchem-2615	139	51	units	unit	NOUN
eurjchem-2615	139	52	along	along	ADP
eurjchem-2615	139	53	with	with	ADP
eurjchem-2615	139	54	the	the	DET
eurjchem-2615	139	55	coumarin	coumarin	NOUN
eurjchem-2615	139	56	core	core	NOUN
eurjchem-2615	139	57	for	for	ADP
eurjchem-2615	139	58	improved	improved	ADJ
eurjchem-2615	139	59	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	139	60	activity	activity	NOUN
eurjchem-2615	139	61	(	(	PUNCT
eurjchem-2615	139	62	6a	6a	NOUN
eurjchem-2615	139	63	,	,	PUNCT
eurjchem-2615	139	64	6b	6b	NOUN
eurjchem-2615	139	65	,	,	PUNCT
eurjchem-2615	139	66	7a	7a	NUM
eurjchem-2615	139	67	,	,	PUNCT
eurjchem-2615	139	68	7b	7b	NUM
eurjchem-2615	139	69	)	)	PUNCT
eurjchem-2615	140	1	[	[	X
eurjchem-2615	140	2	59	59	NUM
eurjchem-2615	140	3	]	]	PUNCT
eurjchem-2615	140	4	.	.	PUNCT
eurjchem-2615	141	1	4.3	4.3	NUM
eurjchem-2615	141	2	.	.	PUNCT
eurjchem-2615	142	1	isoniazid-1,2,3	isoniazid-1,2,3	ADJ
eurjchem-2615	142	2	-	-	ADJ
eurjchem-2615	142	3	triazole	triazole	ADJ
eurjchem-2615	142	4	hybrids	hybrid	NOUN
eurjchem-2615	142	5	isoniazid	isoniazid	NOUN
eurjchem-2615	142	6	(	(	PUNCT
eurjchem-2615	142	7	inh	inh	PROPN
eurjchem-2615	142	8	)	)	PUNCT
eurjchem-2615	142	9	and	and	CCONJ
eurjchem-2615	142	10	1,2,3	1,2,3	NUM
eurjchem-2615	142	11	-	-	ADJ
eurjchem-2615	142	12	triazole	triazole	ADJ
eurjchem-2615	142	13	compounds	compound	NOUN
eurjchem-2615	142	14	share	share	VERB
eurjchem-2615	142	15	a	a	DET
eurjchem-2615	142	16	similar	similar	ADJ
eurjchem-2615	142	17	mechanism	mechanism	NOUN
eurjchem-2615	142	18	of	of	ADP
eurjchem-2615	142	19	action	action	NOUN
eurjchem-2615	142	20	through	through	ADP
eurjchem-2615	142	21	inhibition	inhibition	NOUN
eurjchem-2615	142	22	of	of	ADP
eurjchem-2615	142	23	the	the	DET
eurjchem-2615	142	24	bacterial	bacterial	ADJ
eurjchem-2615	142	25	cell	cell	NOUN
eurjchem-2615	142	26	wall	wall	NOUN
eurjchem-2615	142	27	.	.	PUNCT
eurjchem-2615	143	1	therefore	therefore	ADV
eurjchem-2615	143	2	,	,	PUNCT
eurjchem-2615	143	3	the	the	DET
eurjchem-2615	143	4	combination	combination	NOUN
eurjchem-2615	143	5	of	of	ADP
eurjchem-2615	143	6	these	these	DET
eurjchem-2615	143	7	pharmacophores	pharmacophore	NOUN
eurjchem-2615	143	8	into	into	ADP
eurjchem-2615	143	9	hybrid	hybrid	ADJ
eurjchem-2615	143	10	molecules	molecule	NOUN
eurjchem-2615	143	11	presents	present	VERB
eurjchem-2615	143	12	an	an	DET
eurjchem-2615	143	13	opportunity	opportunity	NOUN
eurjchem-2615	143	14	to	to	PART
eurjchem-2615	143	15	develop	develop	VERB
eurjchem-2615	143	16	novel	novel	ADJ
eurjchem-2615	143	17	antitubercular	antitubercular	ADJ
eurjchem-2615	143	18	agents	agent	NOUN
eurjchem-2615	143	19	with	with	ADP
eurjchem-2615	143	20	enhanced	enhanced	ADJ
eurjchem-2615	143	21	activity	activity	NOUN
eurjchem-2615	143	22	[	[	X
eurjchem-2615	143	23	60	60	NUM
eurjchem-2615	143	24	]	]	PUNCT
eurjchem-2615	143	25	.	.	PUNCT
eurjchem-2615	144	1	the	the	DET
eurjchem-2615	144	2	isoniazid-1,2,3	isoniazid-1,2,3	ADJ
eurjchem-2615	144	3	-	-	ADJ
eurjchem-2615	144	4	triazole	triazole	ADJ
eurjchem-2615	144	5	hybrid	hybrid	NOUN
eurjchem-2615	144	6	6	6	NUM
eurjchem-2615	144	7	(	(	PUNCT
eurjchem-2615	144	8	figure	figure	NOUN
eurjchem-2615	144	9	6	6	NUM
eurjchem-2615	144	10	)	)	PUNCT
eurjchem-2615	144	11	exhibited	exhibit	VERB
eurjchem-2615	144	12	antitubercular	antitubercular	ADJ
eurjchem-2615	144	13	activity	activity	NOUN
eurjchem-2615	144	14	against	against	ADP
eurjchem-2615	144	15	the	the	DET
eurjchem-2615	144	16	mtb	mtb	NOUN
eurjchem-2615	144	17	-	-	PUNCT
eurjchem-2615	144	18	h37rv	h37rv	NOUN
eurjchem-2615	144	19	strain	strain	NOUN
eurjchem-2615	144	20	with	with	ADP
eurjchem-2615	144	21	an	an	DET
eurjchem-2615	144	22	mic	mic	ADJ
eurjchem-2615	144	23	value	value	NOUN
eurjchem-2615	144	24	of	of	ADP
eurjchem-2615	144	25	1.56	1.56	NUM
eurjchem-2615	144	26	,	,	PUNCT
eurjchem-2615	144	27	while	while	SCONJ
eurjchem-2615	144	28	showing	show	VERB
eurjchem-2615	144	29	minimal	minimal	ADJ
eurjchem-2615	144	30	toxicity	toxicity	NOUN
eurjchem-2615	144	31	towards	towards	ADP
eurjchem-2615	144	32	raw	raw	ADJ
eurjchem-2615	144	33	264.7	264.7	NUM
eurjchem-2615	144	34	macrophages	macrophage	NOUN
eurjchem-2615	144	35	.	.	PUNCT
eurjchem-2615	145	1	two	two	NUM
eurjchem-2615	145	2	key	key	ADJ
eurjchem-2615	145	3	enzymes	enzyme	NOUN
eurjchem-2615	145	4	involved	involve	VERB
eurjchem-2615	145	5	in	in	ADP
eurjchem-2615	145	6	mycobacterial	mycobacterial	ADJ
eurjchem-2615	145	7	cell	cell	NOUN
eurjchem-2615	145	8	wall	wall	NOUN
eurjchem-2615	145	9	synthesis	synthesis	NOUN
eurjchem-2615	145	10	and	and	CCONJ
eurjchem-2615	145	11	bacterial	bacterial	ADJ
eurjchem-2615	145	12	growth	growth	NOUN
eurjchem-2615	145	13	are	be	AUX
eurjchem-2615	145	14	enoyl	enoyl	NOUN
eurjchem-2615	145	15	-	-	PUNCT
eurjchem-2615	145	16	acp	acp	PROPN
eurjchem-2615	145	17	reductase	reductase	NOUN
eurjchem-2615	145	18	(	(	PUNCT
eurjchem-2615	145	19	inha	inha	NOUN
eurjchem-2615	145	20	)	)	PUNCT
eurjchem-2615	145	21	and	and	CCONJ
eurjchem-2615	145	22	dna	dna	PROPN
eurjchem-2615	145	23	gyrase	gyrase	NOUN
eurjchem-2615	145	24	.	.	PUNCT
eurjchem-2615	146	1	molecular	molecular	ADJ
eurjchem-2615	146	2	docking	docking	NOUN
eurjchem-2615	146	3	studies	study	NOUN
eurjchem-2615	146	4	revealed	reveal	VERB
eurjchem-2615	146	5	that	that	SCONJ
eurjchem-2615	146	6	compound	compound	NOUN
eurjchem-2615	146	7	8	8	NUM
eurjchem-2615	146	8	demonstrates	demonstrate	VERB
eurjchem-2615	146	9	a	a	DET
eurjchem-2615	146	10	strong	strong	ADJ
eurjchem-2615	146	11	binding	bind	VERB
eurjchem-2615	146	12	affinity	affinity	NOUN
eurjchem-2615	146	13	for	for	ADP
eurjchem-2615	146	14	dna	dna	PROPN
eurjchem-2615	146	15	gyrase	gyrase	NOUN
eurjchem-2615	146	16	and	and	CCONJ
eurjchem-2615	146	17	inha	inha	NOUN
eurjchem-2615	146	18	,	,	PUNCT
eurjchem-2615	146	19	suggesting	suggest	VERB
eurjchem-2615	146	20	its	its	PRON
eurjchem-2615	146	21	potential	potential	NOUN
eurjchem-2615	146	22	as	as	ADP
eurjchem-2615	146	23	a	a	DET
eurjchem-2615	146	24	promising	promising	ADJ
eurjchem-2615	146	25	lead	lead	NOUN
eurjchem-2615	146	26	compound	compound	NOUN
eurjchem-2615	146	27	for	for	ADP
eurjchem-2615	146	28	the	the	DET
eurjchem-2615	146	29	development	development	NOUN
eurjchem-2615	146	30	of	of	ADP
eurjchem-2615	146	31	mechanismbased	mechanismbase	VERB
eurjchem-2615	146	32	antituberculosis	antituberculosis	NOUN
eurjchem-2615	146	33	agents	agent	NOUN
eurjchem-2615	146	34	[	[	X
eurjchem-2615	146	35	61	61	NUM
eurjchem-2615	146	36	]	]	PUNCT
eurjchem-2615	146	37	.	.	PUNCT
eurjchem-2615	147	1	hybrids	hybrid	NOUN
eurjchem-2615	147	2	9a	9a	NOUN
eurjchem-2615	147	3	-	-	PUNCT
eurjchem-2615	147	4	e	e	NOUN
eurjchem-2615	147	5	demonstrated	demonstrate	VERB
eurjchem-2615	147	6	favorable	favorable	ADJ
eurjchem-2615	147	7	safety	safety	NOUN
eurjchem-2615	147	8	profiles	profile	NOUN
eurjchem-2615	147	9	with	with	ADP
eurjchem-2615	147	10	low	low	ADJ
eurjchem-2615	147	11	cytotoxicity	cytotoxicity	NOUN
eurjchem-2615	147	12	(	(	PUNCT
eurjchem-2615	147	13	mdl50	mdl50	NOUN
eurjchem-2615	147	14	>	>	X
eurjchem-2615	147	15	1000	1000	NUM
eurjchem-2615	147	16	μg	μg	NOUN
eurjchem-2615	147	17	/	/	SYM
eurjchem-2615	147	18	ml	ml	NOUN
eurjchem-2615	147	19	)	)	PUNCT
eurjchem-2615	147	20	when	when	SCONJ
eurjchem-2615	147	21	tested	test	VERB
eurjchem-2615	147	22	against	against	ADP
eurjchem-2615	147	23	both	both	DET
eurjchem-2615	147	24	hepatoma	hepatoma	NOUN
eurjchem-2615	147	25	hepg2	hepg2	VERB
eurjchem-2615	147	26	liver	liver	NOUN
eurjchem-2615	147	27	cells	cell	NOUN
eurjchem-2615	147	28	and	and	CCONJ
eurjchem-2615	147	29	bgm	bgm	NOUN
eurjchem-2615	147	30	kidney	kidney	NOUN
eurjchem-2615	147	31	cells	cell	NOUN
eurjchem-2615	147	32	.	.	PUNCT
eurjchem-2615	148	1	their	their	PRON
eurjchem-2615	148	2	high	high	ADJ
eurjchem-2615	148	3	selectivity	selectivity	NOUN
eurjchem-2615	148	4	index	index	NOUN
eurjchem-2615	148	5	suggests	suggest	VERB
eurjchem-2615	148	6	that	that	SCONJ
eurjchem-2615	148	7	these	these	DET
eurjchem-2615	148	8	compounds	compound	NOUN
eurjchem-2615	148	9	could	could	AUX
eurjchem-2615	148	10	be	be	AUX
eurjchem-2615	148	11	promising	promise	VERB
eurjchem-2615	148	12	candidates	candidate	NOUN
eurjchem-2615	148	13	for	for	ADP
eurjchem-2615	148	14	the	the	DET
eurjchem-2615	148	15	development	development	NOUN
eurjchem-2615	148	16	of	of	ADP
eurjchem-2615	148	17	safe	safe	ADJ
eurjchem-2615	148	18	and	and	CCONJ
eurjchem-2615	148	19	effective	effective	ADJ
eurjchem-2615	148	20	antitubercular	antitubercular	ADJ
eurjchem-2615	148	21	agents	agent	NOUN
eurjchem-2615	148	22	[	[	X
eurjchem-2615	148	23	62	62	NUM
eurjchem-2615	148	24	]	]	PUNCT
eurjchem-2615	148	25	.	.	PUNCT
eurjchem-2615	149	1	similarly	similarly	ADV
eurjchem-2615	149	2	,	,	PUNCT
eurjchem-2615	149	3	inh	inh	PROPN
eurjchem-2615	149	4	-	-	PUNCT
eurjchem-2615	149	5	incorporated	incorporate	VERB
eurjchem-2615	149	6	triazole	triazole	NOUN
eurjchem-2615	149	7	compounds	compound	NOUN
eurjchem-2615	149	8	8	8	NUM
eurjchem-2615	149	9	showed	show	VERB
eurjchem-2615	149	10	notable	notable	ADJ
eurjchem-2615	149	11	antitubercular	antitubercular	ADJ
eurjchem-2615	149	12	activity	activity	NOUN
eurjchem-2615	149	13	against	against	ADP
eurjchem-2615	149	14	m.	m.	NOUN
eurjchem-2615	149	15	tuberculosis	tuberculosis	NOUN
eurjchem-2615	149	16	h37rv	h37rv	PROPN
eurjchem-2615	149	17	strain	strain	NOUN
eurjchem-2615	149	18	(	(	PUNCT
eurjchem-2615	149	19	mic	mic	ADJ
eurjchem-2615	149	20	:	:	PUNCT
eurjchem-2615	149	21	0.78	0.78	NUM
eurjchem-2615	149	22	-	-	PUNCT
eurjchem-2615	149	23	3.125	3.125	NUM
eurjchem-2615	149	24	μg	μg	NOUN
eurjchem-2615	149	25	/	/	SYM
eurjchem-2615	149	26	ml	ml	NOUN
eurjchem-2615	149	27	)	)	PUNCT
eurjchem-2615	149	28	while	while	SCONJ
eurjchem-2615	149	29	demonstrating	demonstrate	VERB
eurjchem-2615	149	30	no	no	DET
eurjchem-2615	149	31	toxicity	toxicity	NOUN
eurjchem-2615	149	32	to	to	ADP
eurjchem-2615	149	33	raw	raw	ADJ
eurjchem-2615	149	34	264.7	264.7	NUM
eurjchem-2615	149	35	macrophages	macrophage	NOUN
eurjchem-2615	149	36	at	at	ADP
eurjchem-2615	149	37	concentrations	concentration	NOUN
eurjchem-2615	149	38	up	up	ADP
eurjchem-2615	149	39	to	to	PART
eurjchem-2615	149	40	25	25	NUM
eurjchem-2615	149	41	μg	μg	NOUN
eurjchem-2615	149	42	/	/	SYM
eurjchem-2615	149	43	ml	ml	NOUN
eurjchem-2615	149	44	.	.	PUNCT
eurjchem-2615	150	1	molecular	molecular	ADJ
eurjchem-2615	150	2	modeling	modeling	NOUN
eurjchem-2615	150	3	analysis	analysis	NOUN
eurjchem-2615	150	4	revealed	reveal	VERB
eurjchem-2615	150	5	that	that	SCONJ
eurjchem-2615	150	6	these	these	DET
eurjchem-2615	150	7	hybrids	hybrid	NOUN
eurjchem-2615	150	8	10	10	NUM
eurjchem-2615	150	9	interact	interact	NOUN
eurjchem-2615	150	10	with	with	ADP
eurjchem-2615	150	11	inha	inha	NOUN
eurjchem-2615	150	12	’s	’s	PART
eurjchem-2615	150	13	active	active	ADJ
eurjchem-2615	150	14	sites	site	NOUN
eurjchem-2615	150	15	through	through	ADP
eurjchem-2615	150	16	a	a	DET
eurjchem-2615	150	17	complex	complex	ADJ
eurjchem-2615	150	18	network	network	NOUN
eurjchem-2615	150	19	of	of	ADP
eurjchem-2615	150	20	bonded	bond	VERB
eurjchem-2615	150	21	and	and	CCONJ
eurjchem-2615	150	22	non	non	ADJ
eurjchem-2615	150	23	-	-	ADJ
eurjchem-2615	150	24	bonded	bond	VERB
eurjchem-2615	150	25	interactions	interaction	NOUN
eurjchem-2615	150	26	.	.	PUNCT
eurjchem-2615	151	1	further	further	ADJ
eurjchem-2615	151	2	optimization	optimization	NOUN
eurjchem-2615	151	3	of	of	ADP
eurjchem-2615	151	4	these	these	DET
eurjchem-2615	151	5	compounds	compound	NOUN
eurjchem-2615	151	6	could	could	AUX
eurjchem-2615	151	7	provide	provide	VERB
eurjchem-2615	151	8	a	a	DET
eurjchem-2615	151	9	foundation	foundation	NOUN
eurjchem-2615	151	10	for	for	ADP
eurjchem-2615	151	11	the	the	DET
eurjchem-2615	151	12	development	development	NOUN
eurjchem-2615	151	13	of	of	ADP
eurjchem-2615	151	14	inha	inha	NOUN
eurjchem-2615	151	15	-	-	PUNCT
eurjchem-2615	151	16	specific	specific	ADJ
eurjchem-2615	151	17	antitubercular	antitubercular	ADJ
eurjchem-2615	151	18	agents	agent	NOUN
eurjchem-2615	151	19	[	[	X
eurjchem-2615	151	20	63	63	NUM
eurjchem-2615	151	21	]	]	PUNCT
eurjchem-2615	151	22	.	.	PUNCT
eurjchem-2615	152	1	hybrid	hybrid	ADJ
eurjchem-2615	152	2	11	11	NUM
eurjchem-2615	152	3	showed	show	VERB
eurjchem-2615	152	4	potent	potent	ADJ
eurjchem-2615	152	5	anti	anti	ADJ
eurjchem-2615	152	6	-	-	ADJ
eurjchem-2615	152	7	tb	tb	ADJ
eurjchem-2615	152	8	activity	activity	NOUN
eurjchem-2615	152	9	(	(	PUNCT
eurjchem-2615	152	10	mic99	mic99	PROPN
eurjchem-2615	152	11	0.39	0.39	NUM
eurjchem-2615	152	12	-	-	SYM
eurjchem-2615	152	13	0.78	0.78	NUM
eurjchem-2615	152	14	μm	μm	NUM
eurjchem-2615	152	15	)	)	PUNCT
eurjchem-2615	152	16	against	against	ADP
eurjchem-2615	152	17	the	the	DET
eurjchem-2615	152	18	h37rv	h37rv	PROPN
eurjchem-2615	152	19	strain	strain	NOUN
eurjchem-2615	152	20	with	with	ADP
eurjchem-2615	152	21	no	no	DET
eurjchem-2615	152	22	toxicity	toxicity	NOUN
eurjchem-2615	152	23	to	to	ADP
eurjchem-2615	152	24	thp-1	thp-1	SYM
eurjchem-2615	152	25	cells	cell	NOUN
eurjchem-2615	152	26	at	at	ADP
eurjchem-2615	152	27	50	50	NUM
eurjchem-2615	152	28	μm	μm	NOUN
eurjchem-2615	152	29	[	[	X
eurjchem-2615	152	30	64	64	NUM
eurjchem-2615	152	31	]	]	PUNCT
eurjchem-2615	152	32	.	.	PUNCT
eurjchem-2615	153	1	4.4	4.4	NUM
eurjchem-2615	153	2	.	.	PUNCT
eurjchem-2615	154	1	1,2,3	1,2,3	NUM
eurjchem-2615	154	2	-	-	ADJ
eurjchem-2615	154	3	triazole	triazole	ADJ
eurjchem-2615	154	4	-	-	PUNCT
eurjchem-2615	154	5	quinoline	quinoline	NOUN
eurjchem-2615	154	6	/	/	SYM
eurjchem-2615	154	7	dihydroquinoline	dihydroquinoline	NOUN
eurjchem-2615	154	8	hybrids	hybrid	NOUN
eurjchem-2615	154	9	quinoline	quinoline	NOUN
eurjchem-2615	154	10	serves	serve	VERB
eurjchem-2615	154	11	as	as	ADP
eurjchem-2615	154	12	a	a	DET
eurjchem-2615	154	13	core	core	NOUN
eurjchem-2615	154	14	scaffold	scaffold	NOUN
eurjchem-2615	154	15	in	in	ADP
eurjchem-2615	154	16	medicinal	medicinal	ADJ
eurjchem-2615	154	17	chemistry	chemistry	NOUN
eurjchem-2615	154	18	[	[	X
eurjchem-2615	154	19	65	65	NUM
eurjchem-2615	154	20	]	]	PUNCT
eurjchem-2615	154	21	.	.	PUNCT
eurjchem-2615	155	1	a	a	DET
eurjchem-2615	155	2	significant	significant	ADJ
eurjchem-2615	155	3	breakthrough	breakthrough	NOUN
eurjchem-2615	155	4	occurred	occur	VERB
eurjchem-2615	155	5	in	in	ADP
eurjchem-2615	155	6	2013	2013	NUM
eurjchem-2615	155	7	when	when	SCONJ
eurjchem-2615	155	8	bedaquiline	bedaquiline	NOUN
eurjchem-2615	155	9	,	,	PUNCT
eurjchem-2615	155	10	the	the	DET
eurjchem-2615	155	11	first	first	ADJ
eurjchem-2615	155	12	drug	drug	NOUN
eurjchem-2615	155	13	based	base	VERB
eurjchem-2615	155	14	on	on	ADP
eurjchem-2615	155	15	diarylquinoline	diarylquinoline	PROPN
eurjchem-2615	155	16	,	,	PUNCT
eurjchem-2615	155	17	received	receive	VERB
eurjchem-2615	155	18	fda	fda	PROPN
eurjchem-2615	155	19	approval	approval	NOUN
eurjchem-2615	155	20	to	to	PART
eurjchem-2615	155	21	treat	treat	VERB
eurjchem-2615	155	22	pulmonary	pulmonary	ADJ
eurjchem-2615	155	23	mdr	mdr	PROPN
eurjchem-2615	155	24	-	-	PROPN
eurjchem-2615	155	25	tb	tb	PROPN
eurjchem-2615	155	26	.	.	PUNCT
eurjchem-2615	155	27	bedaquiline	bedaquiline	PROPN
eurjchem-2615	155	28	works	work	NOUN
eurjchem-2615	155	29	by	by	ADP
eurjchem-2615	155	30	inhibiting	inhibit	VERB
eurjchem-2615	155	31	mycobacterial	mycobacterial	ADJ
eurjchem-2615	155	32	atp	atp	NOUN
eurjchem-2615	155	33	synthase	synthase	NOUN
eurjchem-2615	155	34	,	,	PUNCT
eurjchem-2615	155	35	preventing	prevent	VERB
eurjchem-2615	155	36	m.	m.	NOUN
eurjchem-2615	155	37	tuberculosis	tuberculosis	PRON
eurjchem-2615	155	38	growth	growth	NOUN
eurjchem-2615	155	39	[	[	X
eurjchem-2615	155	40	66	66	NUM
eurjchem-2615	155	41	]	]	PUNCT
eurjchem-2615	155	42	.	.	PUNCT
eurjchem-2615	156	1	however	however	ADV
eurjchem-2615	156	2	,	,	PUNCT
eurjchem-2615	156	3	it	it	PRON
eurjchem-2615	156	4	has	have	VERB
eurjchem-2615	156	5	several	several	ADJ
eurjchem-2615	156	6	limitations	limitation	NOUN
eurjchem-2615	156	7	,	,	PUNCT
eurjchem-2615	156	8	including	include	VERB
eurjchem-2615	156	9	side	side	NOUN
eurjchem-2615	156	10	effects	effect	NOUN
eurjchem-2615	156	11	(	(	PUNCT
eurjchem-2615	156	12	nausea	nausea	NOUN
eurjchem-2615	156	13	,	,	PUNCT
eurjchem-2615	156	14	chest	chest	NOUN
eurjchem-2615	156	15	pain	pain	NOUN
eurjchem-2615	156	16	,	,	PUNCT
eurjchem-2615	156	17	joint	joint	ADJ
eurjchem-2615	156	18	pain	pain	NOUN
eurjchem-2615	156	19	,	,	PUNCT
eurjchem-2615	156	20	headache	headache	NOUN
eurjchem-2615	156	21	)	)	PUNCT
eurjchem-2615	156	22	and	and	CCONJ
eurjchem-2615	156	23	stereochemical	stereochemical	ADJ
eurjchem-2615	156	24	constraints	constraint	NOUN
eurjchem-2615	156	25	,	,	PUNCT
eurjchem-2615	156	26	since	since	SCONJ
eurjchem-2615	156	27	only	only	ADV
eurjchem-2615	156	28	the	the	DET
eurjchem-2615	156	29	1r,2s	1r,2s	NUM
eurjchem-2615	156	30	isomer	isomer	PROPN
eurjchem-2615	156	31	shows	show	VERB
eurjchem-2615	156	32	activity	activity	NOUN
eurjchem-2615	156	33	.	.	PUNCT
eurjchem-2615	157	1	to	to	PART
eurjchem-2615	157	2	address	address	VERB
eurjchem-2615	157	3	these	these	DET
eurjchem-2615	157	4	limitations	limitation	NOUN
eurjchem-2615	157	5	,	,	PUNCT
eurjchem-2615	157	6	the	the	DET
eurjchem-2615	157	7	molecular	molecular	ADJ
eurjchem-2615	157	8	hybridization	hybridization	NOUN
eurjchem-2615	157	9	strategy	strategy	NOUN
eurjchem-2615	157	10	combining	combine	VERB
eurjchem-2615	157	11	quinoline	quinoline	NOUN
eurjchem-2615	157	12	with	with	ADP
eurjchem-2615	157	13	1,2,3	1,2,3	NOUN
eurjchem-2615	157	14	-	-	ADJ
eurjchem-2615	157	15	triazole	triazole	ADJ
eurjchem-2615	157	16	scaffolds	scaffold	NOUN
eurjchem-2615	157	17	was	be	AUX
eurjchem-2615	157	18	used	use	VERB
eurjchem-2615	157	19	to	to	PART
eurjchem-2615	157	20	develop	develop	VERB
eurjchem-2615	157	21	more	more	ADV
eurjchem-2615	157	22	potent	potent	ADJ
eurjchem-2615	157	23	and	and	CCONJ
eurjchem-2615	157	24	selective	selective	ADJ
eurjchem-2615	157	25	analogues	analogue	NOUN
eurjchem-2615	157	26	(	(	PUNCT
eurjchem-2615	157	27	figure	figure	NOUN
eurjchem-2615	157	28	7	7	NUM
eurjchem-2615	157	29	)	)	PUNCT
eurjchem-2615	157	30	.	.	PUNCT
eurjchem-2615	158	1	quinoline-4	quinoline-4	PROPN
eurjchem-2615	158	2	-	-	PUNCT
eurjchem-2615	158	3	yl-1,2,3	yl-1,2,3	NOUN
eurjchem-2615	158	4	-	-	PUNCT
eurjchem-2615	158	5	triazole	triazole	NOUN
eurjchem-2615	158	6	derivatives	derivative	NOUN
eurjchem-2615	158	7	containing	contain	VERB
eurjchem-2615	158	8	amide	amide	NOUN
eurjchem-2615	158	9	12	12	NUM
eurjchem-2615	158	10	,	,	PUNCT
eurjchem-2615	158	11	sulfonamide	sulfonamide	NOUN
eurjchem-2615	158	12	13	13	NUM
eurjchem-2615	158	13	,	,	PUNCT
eurjchem-2615	158	14	and	and	CCONJ
eurjchem-2615	158	15	amidopiperazine	amidopiperazine	VERB
eurjchem-2615	158	16	14	14	NUM
eurjchem-2615	158	17	moieties	moiety	NOUN
eurjchem-2615	158	18	demonstrated	demonstrate	VERB
eurjchem-2615	158	19	significant	significant	ADJ
eurjchem-2615	158	20	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	158	21	activity	activity	NOUN
eurjchem-2615	158	22	in	in	ADP
eurjchem-2615	158	23	vitro	vitro	NOUN
eurjchem-2615	158	24	.	.	PUNCT
eurjchem-2615	159	1	these	these	DET
eurjchem-2615	159	2	compounds	compound	NOUN
eurjchem-2615	159	3	were	be	AUX
eurjchem-2615	159	4	effective	effective	ADJ
eurjchem-2615	159	5	against	against	ADP
eurjchem-2615	159	6	multiple	multiple	ADJ
eurjchem-2615	159	7	mycobacterial	mycobacterial	ADJ
eurjchem-2615	159	8	strains	strain	NOUN
eurjchem-2615	159	9	,	,	PUNCT
eurjchem-2615	159	10	including	include	VERB
eurjchem-2615	159	11	m.	m.	NOUN
eurjchem-2615	159	12	tuberculosis	tuberculosis	NOUN
eurjchem-2615	159	13	h37rv	h37rv	PROPN
eurjchem-2615	159	14	,	,	PUNCT
eurjchem-2615	159	15	m.	m.	NOUN
eurjchem-2615	159	16	smegmatis	smegmatis	PROPN
eurjchem-2615	159	17	,	,	PUNCT
eurjchem-2615	159	18	and	and	CCONJ
eurjchem-2615	159	19	m.	m.	NOUN
eurjchem-2615	159	20	fortuitum	fortuitum	PROPN
eurjchem-2615	159	21	,	,	PUNCT
eurjchem-2615	159	22	with	with	ADP
eurjchem-2615	159	23	mic	mic	ADJ
eurjchem-2615	159	24	values	value	NOUN
eurjchem-2615	159	25	in	in	ADP
eurjchem-2615	159	26	the	the	DET
eurjchem-2615	159	27	range	range	NOUN
eurjchem-2615	159	28	of	of	ADP
eurjchem-2615	159	29	0.625	0.625	NUM
eurjchem-2615	159	30	to	to	PART
eurjchem-2615	159	31	10	10	NUM
eurjchem-2615	159	32	μg	μg	NOUN
eurjchem-2615	159	33	/	/	SYM
eurjchem-2615	159	34	ml	ml	PROPN
eurjchem-2615	160	1	[	[	X
eurjchem-2615	160	2	67	67	NUM
eurjchem-2615	160	3	]	]	PUNCT
eurjchem-2615	160	4	.	.	PUNCT
eurjchem-2615	161	1	sar	sar	PROPN
eurjchem-2615	161	2	analysis	analysis	NOUN
eurjchem-2615	161	3	of	of	ADP
eurjchem-2615	161	4	1,2,3	1,2,3	NUM
eurjchem-2615	161	5	-	-	ADJ
eurjchem-2615	161	6	triazole	triazole	ADJ
eurjchem-2615	161	7	-	-	PUNCT
eurjchem-2615	161	8	dihydroquinoline	dihydroquinoline	NOUN
eurjchem-2615	161	9	hybrids	hybrid	NOUN
eurjchem-2615	161	10	12	12	NUM
eurjchem-2615	161	11	(	(	PUNCT
eurjchem-2615	161	12	mic	mic	ADJ
eurjchem-2615	161	13	:	:	PUNCT
eurjchem-2615	161	14	1.56	1.56	NUM
eurjchem-2615	161	15	-	-	SYM
eurjchem-2615	161	16	25	25	NUM
eurjchem-2615	161	17	μg	μg	PROPN
eurjchem-2615	161	18	/	/	SYM
eurjchem-2615	161	19	ml	ml	NOUN
eurjchem-2615	161	20	)	)	PUNCT
eurjchem-2615	161	21	confirmed	confirm	VERB
eurjchem-2615	161	22	the	the	DET
eurjchem-2615	161	23	importance	importance	NOUN
eurjchem-2615	161	24	of	of	ADP
eurjchem-2615	161	25	substituents	substituent	NOUN
eurjchem-2615	161	26	attached	attach	VERB
eurjchem-2615	161	27	to	to	ADP
eurjchem-2615	161	28	the	the	DET
eurjchem-2615	161	29	1,2,3	1,2,3	NUM
eurjchem-2615	161	30	-	-	ADJ
eurjchem-2615	161	31	triazole	triazole	ADJ
eurjchem-2615	161	32	ring	ring	NOUN
eurjchem-2615	161	33	.	.	PUNCT
eurjchem-2615	162	1	zimo	zimo	VERB
eurjchem-2615	162	2	and	and	CCONJ
eurjchem-2615	162	3	coghi	coghi	PROPN
eurjchem-2615	162	4	/	/	SYM
eurjchem-2615	162	5	european	european	PROPN
eurjchem-2615	162	6	journal	journal	PROPN
eurjchem-2615	162	7	of	of	ADP
eurjchem-2615	162	8	chemistry	chemistry	NOUN
eurjchem-2615	162	9	16	16	NUM
eurjchem-2615	162	10	(	(	PUNCT
eurjchem-2615	162	11	1	1	NUM
eurjchem-2615	162	12	)	)	PUNCT
eurjchem-2615	162	13	(	(	PUNCT
eurjchem-2615	162	14	2025	2025	NUM
eurjchem-2615	162	15	)	)	PUNCT
eurjchem-2615	162	16	83	83	NUM
eurjchem-2615	162	17	-	-	SYM
eurjchem-2615	162	18	96	96	NUM
eurjchem-2615	162	19	89	89	NUM
eurjchem-2615	162	20	2025	2025	NUM
eurjchem-2615	162	21	–	–	PUNCT
eurjchem-2615	162	22	european	european	ADJ
eurjchem-2615	162	23	journal	journal	NOUN
eurjchem-2615	162	24	of	of	ADP
eurjchem-2615	162	25	chemistry	chemistry	NOUN
eurjchem-2615	162	26	–	–	PUNCT
eurjchem-2615	162	27	cc	cc	NOUN
eurjchem-2615	162	28	by	by	ADP
eurjchem-2615	162	29	nc	nc	PROPN
eurjchem-2615	162	30	–	–	PUNCT
eurjchem-2615	162	31	doi	doi	NOUN
eurjchem-2615	162	32	:	:	PUNCT
eurjchem-2615	162	33	10.5155	10.5155	NUM
eurjchem-2615	162	34	/	/	SYM
eurjchem-2615	162	35	eurjchem.16.1.83	eurjchem.16.1.83	ADJ
eurjchem-2615	162	36	-	-	PUNCT
eurjchem-2615	162	37	96.2615	96.2615	NUM
eurjchem-2615	162	38	figure	figure	NOUN
eurjchem-2615	162	39	7	7	NUM
eurjchem-2615	162	40	.	.	PUNCT
eurjchem-2615	163	1	1,2,3	1,2,3	NUM
eurjchem-2615	163	2	-	-	ADJ
eurjchem-2615	163	3	triazole	triazole	ADJ
eurjchem-2615	163	4	-	-	PUNCT
eurjchem-2615	163	5	quinoline	quinoline	NOUN
eurjchem-2615	163	6	/	/	SYM
eurjchem-2615	163	7	dihydroquinoline	dihydroquinoline	NOUN
eurjchem-2615	163	8	hybrids	hybrid	NOUN
eurjchem-2615	163	9	12	12	NUM
eurjchem-2615	163	10	-	-	SYM
eurjchem-2615	163	11	18	18	NUM
eurjchem-2615	163	12	as	as	ADP
eurjchem-2615	163	13	potent	potent	ADJ
eurjchem-2615	163	14	antitubercular	antitubercular	ADJ
eurjchem-2615	163	15	agents	agent	NOUN
eurjchem-2615	163	16	.	.	PUNCT
eurjchem-2615	164	1	hybrid	hybrid	ADJ
eurjchem-2615	164	2	15a	15a	NOUN
eurjchem-2615	164	3	(	(	PUNCT
eurjchem-2615	164	4	mic	mic	NOUN
eurjchem-2615	164	5	:	:	PUNCT
eurjchem-2615	164	6	1.56	1.56	NUM
eurjchem-2615	164	7	μg	μg	NOUN
eurjchem-2615	164	8	/	/	SYM
eurjchem-2615	164	9	ml	ml	NOUN
eurjchem-2615	164	10	)	)	PUNCT
eurjchem-2615	164	11	emerged	emerge	VERB
eurjchem-2615	164	12	as	as	ADP
eurjchem-2615	164	13	a	a	DET
eurjchem-2615	164	14	significant	significant	ADJ
eurjchem-2615	164	15	compound	compound	NOUN
eurjchem-2615	164	16	in	in	ADP
eurjchem-2615	164	17	this	this	DET
eurjchem-2615	164	18	series	series	NOUN
eurjchem-2615	164	19	with	with	ADP
eurjchem-2615	164	20	low	low	ADJ
eurjchem-2615	164	21	cytotoxicity	cytotoxicity	NOUN
eurjchem-2615	164	22	against	against	ADP
eurjchem-2615	164	23	hek293	hek293	PROPN
eurjchem-2615	164	24	t	t	NOUN
eurjchem-2615	164	25	cell	cell	NOUN
eurjchem-2615	164	26	lines	line	NOUN
eurjchem-2615	164	27	[	[	X
eurjchem-2615	164	28	68	68	NUM
eurjchem-2615	164	29	]	]	PUNCT
eurjchem-2615	164	30	.	.	PUNCT
eurjchem-2615	165	1	related	relate	VERB
eurjchem-2615	165	2	spiro	spiro	NOUN
eurjchem-2615	165	3	-	-	PUNCT
eurjchem-2615	165	4	hybrid	hybrid	NOUN
eurjchem-2615	165	5	systems	system	NOUN
eurjchem-2615	165	6	16	16	NUM
eurjchem-2615	165	7	(	(	PUNCT
eurjchem-2615	165	8	mic	mic	ADJ
eurjchem-2615	165	9	:	:	PUNCT
eurjchem-2615	165	10	1.13	1.13	NUM
eurjchem-2615	165	11	-	-	SYM
eurjchem-2615	165	12	25.0	25.0	NUM
eurjchem-2615	165	13	μm	μm	NOUN
eurjchem-2615	165	14	)	)	PUNCT
eurjchem-2615	165	15	showed	show	VERB
eurjchem-2615	165	16	promising	promise	VERB
eurjchem-2615	165	17	antitubercular	antitubercular	ADJ
eurjchem-2615	165	18	activity	activity	NOUN
eurjchem-2615	165	19	against	against	ADP
eurjchem-2615	165	20	m.	m.	NOUN
eurjchem-2615	165	21	tuberculosis	tuberculosis	NOUN
eurjchem-2615	165	22	h37rv	h37rv	PROPN
eurjchem-2615	165	23	(	(	PUNCT
eurjchem-2615	165	24	atcc27294	atcc27294	PROPN
eurjchem-2615	165	25	)	)	PUNCT
eurjchem-2615	165	26	compared	compare	VERB
eurjchem-2615	165	27	to	to	ADP
eurjchem-2615	165	28	the	the	DET
eurjchem-2615	165	29	standard	standard	ADJ
eurjchem-2615	165	30	drug	drug	NOUN
eurjchem-2615	165	31	ethambutol	ethambutol	NOUN
eurjchem-2615	165	32	(	(	PUNCT
eurjchem-2615	165	33	mic	mic	NOUN
eurjchem-2615	165	34	:	:	PUNCT
eurjchem-2615	165	35	7.64	7.64	NUM
eurjchem-2615	165	36	μm	μm	NUM
eurjchem-2615	165	37	)	)	PUNCT
eurjchem-2615	165	38	,	,	PUNCT
eurjchem-2615	165	39	while	while	SCONJ
eurjchem-2615	165	40	maintaining	maintain	VERB
eurjchem-2615	165	41	low	low	ADJ
eurjchem-2615	165	42	toxicity	toxicity	NOUN
eurjchem-2615	165	43	against	against	ADP
eurjchem-2615	165	44	raw-264.7	raw-264.7	NOUN
eurjchem-2615	165	45	cell	cell	NOUN
eurjchem-2615	165	46	lines	line	NOUN
eurjchem-2615	165	47	.	.	PUNCT
eurjchem-2615	166	1	the	the	DET
eurjchem-2615	166	2	presence	presence	NOUN
eurjchem-2615	166	3	of	of	ADP
eurjchem-2615	166	4	electron	electron	NOUN
eurjchem-2615	166	5	-	-	PUNCT
eurjchem-2615	166	6	withdrawing	withdraw	VERB
eurjchem-2615	166	7	groups	group	NOUN
eurjchem-2615	166	8	(	(	PUNCT
eurjchem-2615	166	9	-f	-f	NUM
eurjchem-2615	166	10	,	,	PUNCT
eurjchem-2615	166	11	-cl	-cl	INTJ
eurjchem-2615	166	12	,	,	PUNCT
eurjchem-2615	166	13	-br	-br	NOUN
eurjchem-2615	166	14	)	)	PUNCT
eurjchem-2615	166	15	at	at	ADP
eurjchem-2615	166	16	the	the	DET
eurjchem-2615	166	17	4th	4th	ADJ
eurjchem-2615	166	18	position	position	NOUN
eurjchem-2615	166	19	of	of	ADP
eurjchem-2615	166	20	the	the	DET
eurjchem-2615	166	21	benzoyl	benzoyl	NOUN
eurjchem-2615	166	22	system	system	NOUN
eurjchem-2615	166	23	in	in	ADP
eurjchem-2615	166	24	hybrid	hybrid	ADJ
eurjchem-2615	166	25	16	16	NUM
eurjchem-2615	166	26	proved	prove	VERB
eurjchem-2615	166	27	crucial	crucial	ADJ
eurjchem-2615	166	28	for	for	ADP
eurjchem-2615	166	29	activity	activity	NOUN
eurjchem-2615	166	30	.	.	PUNCT
eurjchem-2615	167	1	additionally	additionally	ADV
eurjchem-2615	167	2	,	,	PUNCT
eurjchem-2615	167	3	substitution	substitution	NOUN
eurjchem-2615	167	4	at	at	ADP
eurjchem-2615	167	5	the	the	DET
eurjchem-2615	167	6	fifth	fifth	ADJ
eurjchem-2615	167	7	position	position	NOUN
eurjchem-2615	167	8	of	of	ADP
eurjchem-2615	167	9	the	the	DET
eurjchem-2615	167	10	isatin	isatin	ADJ
eurjchem-2615	167	11	moiety	moiety	NOUN
eurjchem-2615	167	12	in	in	ADP
eurjchem-2615	167	13	16	16	NUM
eurjchem-2615	167	14	also	also	ADV
eurjchem-2615	167	15	influences	influence	VERB
eurjchem-2615	167	16	its	its	PRON
eurjchem-2615	167	17	biological	biological	ADJ
eurjchem-2615	167	18	activity	activity	NOUN
eurjchem-2615	167	19	[	[	X
eurjchem-2615	167	20	69	69	NUM
eurjchem-2615	167	21	]	]	PUNCT
eurjchem-2615	167	22	.	.	PUNCT
eurjchem-2615	168	1	the	the	DET
eurjchem-2615	168	2	derivative	derivative	ADJ
eurjchem-2615	168	3	17	17	NUM
eurjchem-2615	168	4	has	have	AUX
eurjchem-2615	168	5	been	be	AUX
eurjchem-2615	168	6	tested	test	VERB
eurjchem-2615	168	7	for	for	ADP
eurjchem-2615	168	8	in	in	ADP
eurjchem-2615	168	9	vitro	vitro	X
eurjchem-2615	168	10	antibacterial	antibacterial	ADJ
eurjchem-2615	168	11	activity	activity	NOUN
eurjchem-2615	168	12	against	against	ADP
eurjchem-2615	168	13	mycobacterium	mycobacterium	NOUN
eurjchem-2615	168	14	tuberculosis	tuberculosis	NOUN
eurjchem-2615	168	15	h37rv	h37rv	NOUN
eurjchem-2615	168	16	,	,	PUNCT
eurjchem-2615	168	17	escherichia	escherichia	NOUN
eurjchem-2615	168	18	coli	coli	NOUN
eurjchem-2615	168	19	,	,	PUNCT
eurjchem-2615	168	20	proteus	proteus	NOUN
eurjchem-2615	168	21	mirabilis	mirabilis	PROPN
eurjchem-2615	168	22	,	,	PUNCT
eurjchem-2615	168	23	bacillus	bacillus	NOUN
eurjchem-2615	168	24	subtilis	subtili	NOUN
eurjchem-2615	168	25	and	and	CCONJ
eurjchem-2615	168	26	corynebacterium	corynebacterium	NOUN
eurjchem-2615	168	27	diphtheriae	diphtheriae	NOUN
eurjchem-2615	168	28	,	,	PUNCT
eurjchem-2615	168	29	showing	show	VERB
eurjchem-2615	168	30	good	good	ADJ
eurjchem-2615	168	31	antibacterial	antibacterial	ADJ
eurjchem-2615	168	32	activity	activity	NOUN
eurjchem-2615	168	33	and	and	CCONJ
eurjchem-2615	168	34	excellent	excellent	ADJ
eurjchem-2615	168	35	to	to	ADP
eurjchem-2615	168	36	good	good	ADJ
eurjchem-2615	168	37	antituberculosis	antituberculosis	NOUN
eurjchem-2615	168	38	activity	activity	NOUN
eurjchem-2615	168	39	,	,	PUNCT
eurjchem-2615	168	40	with	with	ADP
eurjchem-2615	168	41	mic	mic	ADJ
eurjchem-2615	168	42	values	value	NOUN
eurjchem-2615	168	43	of	of	ADP
eurjchem-2615	168	44	62.5	62.5	NUM
eurjchem-2615	168	45	and	and	CCONJ
eurjchem-2615	168	46	3.33	3.33	NUM
eurjchem-2615	168	47	μm	μm	NOUN
eurjchem-2615	168	48	,	,	PUNCT
eurjchem-2615	168	49	respectively	respectively	ADV
eurjchem-2615	168	50	.	.	PUNCT
eurjchem-2615	169	1	the	the	DET
eurjchem-2615	169	2	compound	compound	NOUN
eurjchem-2615	169	3	also	also	ADV
eurjchem-2615	169	4	achieved	achieve	VERB
eurjchem-2615	169	5	high	high	ADJ
eurjchem-2615	169	6	docking	docking	NOUN
eurjchem-2615	169	7	scores	score	NOUN
eurjchem-2615	169	8	in	in	ADP
eurjchem-2615	169	9	two	two	NUM
eurjchem-2615	169	10	targets	target	NOUN
eurjchem-2615	169	11	,	,	PUNCT
eurjchem-2615	169	12	8.291	8.291	NUM
eurjchem-2615	169	13	and	and	CCONJ
eurjchem-2615	169	14	8.885	8.885	NUM
eurjchem-2615	169	15	kcal	kcal	NOUN
eurjchem-2615	169	16	/	/	SYM
eurjchem-2615	169	17	mol	mol	NOUN
eurjchem-2615	169	18	.	.	PUNCT
eurjchem-2615	170	1	molecular	molecular	ADJ
eurjchem-2615	170	2	dynamics	dynamic	NOUN
eurjchem-2615	170	3	studies	study	NOUN
eurjchem-2615	170	4	investigated	investigate	VERB
eurjchem-2615	170	5	the	the	DET
eurjchem-2615	170	6	structural	structural	ADJ
eurjchem-2615	170	7	and	and	CCONJ
eurjchem-2615	170	8	dynamic	dynamic	ADJ
eurjchem-2615	170	9	transitions	transition	NOUN
eurjchem-2615	170	10	of	of	ADP
eurjchem-2615	170	11	staphylococcus	staphylococcus	NOUN
eurjchem-2615	170	12	aureus	aureus	NOUN
eurjchem-2615	170	13	dna	dna	PROPN
eurjchem-2615	170	14	gyrase	gyrase	NOUN
eurjchem-2615	170	15	(	(	PUNCT
eurjchem-2615	170	16	pdb	pdb	PROPN
eurjchem-2615	170	17	code	code	PROPN
eurjchem-2615	170	18	2xct	2xct	PROPN
eurjchem-2615	170	19	)	)	PUNCT
eurjchem-2615	170	20	and	and	CCONJ
eurjchem-2615	170	21	mycobacterium	mycobacterium	NOUN
eurjchem-2615	170	22	tuberculosis	tuberculosis	NOUN
eurjchem-2615	170	23	dna	dna	NOUN
eurjchem-2615	170	24	gyrase	gyrase	NOUN
eurjchem-2615	170	25	(	(	PUNCT
eurjchem-2615	170	26	pdb	pdb	PROPN
eurjchem-2615	170	27	code	code	PROPN
eurjchem-2615	170	28	5bs8	5bs8	PROPN
eurjchem-2615	170	29	)	)	PUNCT
eurjchem-2615	170	30	at	at	ADP
eurjchem-2615	170	31	the	the	DET
eurjchem-2615	170	32	atomic	atomic	ADJ
eurjchem-2615	170	33	level	level	NOUN
eurjchem-2615	170	34	.	.	PUNCT
eurjchem-2615	171	1	the	the	DET
eurjchem-2615	171	2	results	result	NOUN
eurjchem-2615	171	3	indicated	indicate	VERB
eurjchem-2615	171	4	that	that	SCONJ
eurjchem-2615	171	5	throughout	throughout	ADP
eurjchem-2615	171	6	the	the	DET
eurjchem-2615	171	7	md	md	PROPN
eurjchem-2615	171	8	simulation	simulation	PROPN
eurjchem-2615	171	9	,	,	PUNCT
eurjchem-2615	171	10	the	the	DET
eurjchem-2615	171	11	residues	residue	NOUN
eurjchem-2615	171	12	in	in	ADP
eurjchem-2615	171	13	the	the	DET
eurjchem-2615	171	14	active	active	ADJ
eurjchem-2615	171	15	binding	bind	VERB
eurjchem-2615	171	16	pockets	pocket	NOUN
eurjchem-2615	171	17	of	of	ADP
eurjchem-2615	171	18	the	the	DET
eurjchem-2615	171	19	staphylococcus	staphylococcus	NOUN
eurjchem-2615	171	20	aureus	aureus	NOUN
eurjchem-2615	171	21	and	and	CCONJ
eurjchem-2615	171	22	mycobacterium	mycobacterium	NOUN
eurjchem-2615	171	23	tuberculosis	tuberculosis	NOUN
eurjchem-2615	171	24	dna	dna	NOUN
eurjchem-2615	171	25	gyrase	gyrase	NOUN
eurjchem-2615	171	26	proteins	protein	NOUN
eurjchem-2615	171	27	that	that	PRON
eurjchem-2615	171	28	interacted	interact	VERB
eurjchem-2615	171	29	with	with	ADP
eurjchem-2615	171	30	compound	compound	NOUN
eurjchem-2615	171	31	17	17	NUM
eurjchem-2615	171	32	remained	remain	VERB
eurjchem-2615	171	33	relatively	relatively	ADV
eurjchem-2615	171	34	consistent	consistent	ADJ
eurjchem-2615	171	35	,	,	PUNCT
eurjchem-2615	171	36	reflecting	reflect	VERB
eurjchem-2615	171	37	the	the	DET
eurjchem-2615	171	38	conformational	conformational	ADJ
eurjchem-2615	171	39	stability	stability	NOUN
eurjchem-2615	171	40	of	of	ADP
eurjchem-2615	171	41	the	the	DET
eurjchem-2615	171	42	respective	respective	ADJ
eurjchem-2615	171	43	complexes	complex	NOUN
eurjchem-2615	171	44	[	[	X
eurjchem-2615	171	45	70	70	NUM
eurjchem-2615	171	46	]	]	PUNCT
eurjchem-2615	171	47	.	.	PUNCT
eurjchem-2615	172	1	compound	compound	NOUN
eurjchem-2615	172	2	18	18	NUM
eurjchem-2615	172	3	has	have	AUX
eurjchem-2615	172	4	been	be	AUX
eurjchem-2615	172	5	tested	test	VERB
eurjchem-2615	172	6	for	for	ADP
eurjchem-2615	172	7	in	in	ADP
eurjchem-2615	172	8	vitro	vitro	X
eurjchem-2615	172	9	antibacterial	antibacterial	ADJ
eurjchem-2615	172	10	activity	activity	NOUN
eurjchem-2615	172	11	against	against	ADP
eurjchem-2615	172	12	mycobacterium	mycobacterium	NOUN
eurjchem-2615	172	13	tuberculosis	tuberculosis	NOUN
eurjchem-2615	172	14	h37rv	h37rv	PROPN
eurjchem-2615	172	15	,	,	PUNCT
eurjchem-2615	172	16	which	which	PRON
eurjchem-2615	172	17	shows	show	VERB
eurjchem-2615	172	18	excellent	excellent	ADJ
eurjchem-2615	172	19	antituberculosis	antituberculosis	NOUN
eurjchem-2615	172	20	activity	activity	NOUN
eurjchem-2615	172	21	with	with	ADP
eurjchem-2615	172	22	an	an	DET
eurjchem-2615	172	23	mic	mic	ADJ
eurjchem-2615	172	24	value	value	NOUN
eurjchem-2615	172	25	of	of	ADP
eurjchem-2615	172	26	6.24	6.24	NUM
eurjchem-2615	172	27	μg	μg	NOUN
eurjchem-2615	172	28	/	/	SYM
eurjchem-2615	172	29	ml	ml	PROPN
eurjchem-2615	172	30	.	.	PUNCT
eurjchem-2615	173	1	this	this	DET
eurjchem-2615	173	2	compound	compound	NOUN
eurjchem-2615	173	3	also	also	ADV
eurjchem-2615	173	4	showed	show	VERB
eurjchem-2615	173	5	promising	promise	VERB
eurjchem-2615	173	6	antibacterial	antibacterial	ADJ
eurjchem-2615	173	7	activity	activity	NOUN
eurjchem-2615	173	8	against	against	ADP
eurjchem-2615	173	9	escherichia	escherichia	NOUN
eurjchem-2615	173	10	coli	coli	NOUN
eurjchem-2615	173	11	and	and	CCONJ
eurjchem-2615	173	12	other	other	ADJ
eurjchem-2615	173	13	grampositive	grampositive	ADJ
eurjchem-2615	173	14	bacteria	bacteria	NOUN
eurjchem-2615	173	15	,	,	PUNCT
eurjchem-2615	173	16	with	with	ADP
eurjchem-2615	173	17	mic	mic	ADJ
eurjchem-2615	173	18	values	value	NOUN
eurjchem-2615	173	19	in	in	ADP
eurjchem-2615	173	20	the	the	DET
eurjchem-2615	173	21	low	low	ADJ
eurjchem-2615	173	22	micromolar	micromolar	ADJ
eurjchem-2615	173	23	range	range	NOUN
eurjchem-2615	173	24	.	.	PUNCT
eurjchem-2615	174	1	18	18	NUM
eurjchem-2615	174	2	achieved	achieve	VERB
eurjchem-2615	174	3	high	high	ADJ
eurjchem-2615	174	4	docking	docking	NOUN
eurjchem-2615	174	5	scores	score	NOUN
eurjchem-2615	174	6	on	on	ADP
eurjchem-2615	174	7	two	two	NUM
eurjchem-2615	174	8	targets	target	NOUN
eurjchem-2615	174	9	,	,	PUNCT
eurjchem-2615	174	10	8.291	8.291	NUM
eurjchem-2615	174	11	and	and	CCONJ
eurjchem-2615	174	12	8.885	8.885	NUM
eurjchem-2615	174	13	kcal	kcal	NOUN
eurjchem-2615	174	14	/	/	SYM
eurjchem-2615	174	15	mol	mol	PROPN
eurjchem-2615	174	16	,	,	PUNCT
eurjchem-2615	174	17	indicating	indicate	VERB
eurjchem-2615	174	18	a	a	DET
eurjchem-2615	174	19	strong	strong	ADJ
eurjchem-2615	174	20	affinity	affinity	NOUN
eurjchem-2615	174	21	for	for	ADP
eurjchem-2615	174	22	the	the	DET
eurjchem-2615	174	23	active	active	ADJ
eurjchem-2615	174	24	sites	site	NOUN
eurjchem-2615	174	25	of	of	ADP
eurjchem-2615	174	26	the	the	DET
eurjchem-2615	174	27	enzymes	enzyme	NOUN
eurjchem-2615	174	28	.	.	PUNCT
eurjchem-2615	175	1	molecular	molecular	ADJ
eurjchem-2615	175	2	dynamics	dynamic	NOUN
eurjchem-2615	175	3	studies	study	NOUN
eurjchem-2615	175	4	revealed	reveal	VERB
eurjchem-2615	175	5	that	that	SCONJ
eurjchem-2615	175	6	throughout	throughout	ADP
eurjchem-2615	175	7	the	the	DET
eurjchem-2615	175	8	md	md	PROPN
eurjchem-2615	175	9	simulation	simulation	PROPN
eurjchem-2615	175	10	,	,	PUNCT
eurjchem-2615	175	11	the	the	DET
eurjchem-2615	175	12	residues	residue	NOUN
eurjchem-2615	175	13	in	in	ADP
eurjchem-2615	175	14	the	the	DET
eurjchem-2615	175	15	active	active	ADJ
eurjchem-2615	175	16	binding	bind	VERB
eurjchem-2615	175	17	pockets	pocket	NOUN
eurjchem-2615	175	18	of	of	ADP
eurjchem-2615	175	19	staphylococcus	staphylococcus	NOUN
eurjchem-2615	175	20	aureus	aureus	PROPN
eurjchem-2615	175	21	dna	dna	PROPN
eurjchem-2615	175	22	gyrase	gyrase	NOUN
eurjchem-2615	175	23	(	(	PUNCT
eurjchem-2615	175	24	pdb	pdb	PROPN
eurjchem-2615	175	25	code	code	PROPN
eurjchem-2615	175	26	2xct	2xct	PROPN
eurjchem-2615	175	27	)	)	PUNCT
eurjchem-2615	175	28	and	and	CCONJ
eurjchem-2615	175	29	mycobacterium	mycobacterium	NOUN
eurjchem-2615	175	30	tuberculosis	tuberculosis	NOUN
eurjchem-2615	175	31	dna	dna	NOUN
eurjchem-2615	175	32	gyrase	gyrase	NOUN
eurjchem-2615	175	33	(	(	PUNCT
eurjchem-2615	175	34	pdb	pdb	PROPN
eurjchem-2615	175	35	code	code	PROPN
eurjchem-2615	175	36	5bs8	5bs8	PROPN
eurjchem-2615	175	37	)	)	PUNCT
eurjchem-2615	175	38	that	that	PRON
eurjchem-2615	175	39	interacted	interact	VERB
eurjchem-2615	175	40	with	with	ADP
eurjchem-2615	175	41	compound	compound	NOUN
eurjchem-2615	175	42	18	18	NUM
eurjchem-2615	175	43	remained	remain	VERB
eurjchem-2615	175	44	relatively	relatively	ADV
eurjchem-2615	175	45	consistent	consistent	ADJ
eurjchem-2615	175	46	,	,	PUNCT
eurjchem-2615	175	47	reflecting	reflect	VERB
eurjchem-2615	175	48	the	the	DET
eurjchem-2615	175	49	conformational	conformational	ADJ
eurjchem-2615	175	50	stability	stability	NOUN
eurjchem-2615	175	51	of	of	ADP
eurjchem-2615	175	52	the	the	DET
eurjchem-2615	175	53	respective	respective	ADJ
eurjchem-2615	175	54	complexes	complex	NOUN
eurjchem-2615	175	55	,	,	PUNCT
eurjchem-2615	175	56	which	which	PRON
eurjchem-2615	175	57	underscores	underscore	VERB
eurjchem-2615	175	58	/	/	SYM
eurjchem-2615	175	59	highlighting	highlighting	NOUN
eurjchem-2615	175	60	?	?	PUNCT
eurjchem-2615	176	1	its	its	PRON
eurjchem-2615	176	2	potential	potential	NOUN
eurjchem-2615	176	3	as	as	ADP
eurjchem-2615	176	4	a	a	DET
eurjchem-2615	176	5	leading	lead	VERB
eurjchem-2615	176	6	candidate	candidate	NOUN
eurjchem-2615	176	7	for	for	ADP
eurjchem-2615	176	8	further	further	ADJ
eurjchem-2615	176	9	development	development	NOUN
eurjchem-2615	176	10	in	in	ADP
eurjchem-2615	176	11	tuberculosis	tuberculosis	NOUN
eurjchem-2615	176	12	therapeutics	therapeutic	NOUN
eurjchem-2615	176	13	[	[	X
eurjchem-2615	176	14	71	71	NUM
eurjchem-2615	176	15	]	]	PUNCT
eurjchem-2615	176	16	.	.	PUNCT
eurjchem-2615	177	1	4.5	4.5	NUM
eurjchem-2615	177	2	.	.	PUNCT
eurjchem-2615	178	1	1,2,3	1,2,3	NUM
eurjchem-2615	178	2	-	-	ADJ
eurjchem-2615	178	3	triazole	triazole	ADJ
eurjchem-2615	178	4	-	-	PUNCT
eurjchem-2615	178	5	quinolone	quinolone	NOUN
eurjchem-2615	178	6	hybrids	hybrid	NOUN
eurjchem-2615	178	7	quinolones	quinolone	NOUN
eurjchem-2615	178	8	represent	represent	VERB
eurjchem-2615	178	9	a	a	DET
eurjchem-2615	178	10	significant	significant	ADJ
eurjchem-2615	178	11	and	and	CCONJ
eurjchem-2615	178	12	widely	widely	ADV
eurjchem-2615	178	13	studied	study	VERB
eurjchem-2615	178	14	class	class	NOUN
eurjchem-2615	178	15	of	of	ADP
eurjchem-2615	178	16	traditional	traditional	ADJ
eurjchem-2615	178	17	antibiotics	antibiotic	NOUN
eurjchem-2615	178	18	known	know	VERB
eurjchem-2615	178	19	for	for	ADP
eurjchem-2615	178	20	their	their	PRON
eurjchem-2615	178	21	broad	broad	ADJ
eurjchem-2615	178	22	-	-	PUNCT
eurjchem-2615	178	23	spectrum	spectrum	NOUN
eurjchem-2615	178	24	antibacterial	antibacterial	ADJ
eurjchem-2615	178	25	activity	activity	NOUN
eurjchem-2615	178	26	.	.	PUNCT
eurjchem-2615	179	1	these	these	DET
eurjchem-2615	179	2	compounds	compound	NOUN
eurjchem-2615	179	3	are	be	AUX
eurjchem-2615	179	4	particularly	particularly	ADV
eurjchem-2615	179	5	effective	effective	ADJ
eurjchem-2615	179	6	against	against	ADP
eurjchem-2615	179	7	a	a	DET
eurjchem-2615	179	8	variety	variety	NOUN
eurjchem-2615	179	9	of	of	ADP
eurjchem-2615	179	10	bacterial	bacterial	ADJ
eurjchem-2615	179	11	infections	infection	NOUN
eurjchem-2615	179	12	due	due	ADP
eurjchem-2615	179	13	to	to	ADP
eurjchem-2615	179	14	their	their	PRON
eurjchem-2615	179	15	mechanism	mechanism	NOUN
eurjchem-2615	179	16	of	of	ADP
eurjchem-2615	179	17	action	action	NOUN
eurjchem-2615	179	18	,	,	PUNCT
eurjchem-2615	179	19	which	which	PRON
eurjchem-2615	179	20	involves	involve	VERB
eurjchem-2615	179	21	inhibiting	inhibit	VERB
eurjchem-2615	179	22	bacterial	bacterial	ADJ
eurjchem-2615	179	23	dna	dna	NOUN
eurjchem-2615	179	24	gyrase	gyrase	NOUN
eurjchem-2615	179	25	and	and	CCONJ
eurjchem-2615	179	26	topoisomerase	topoisomerase	NOUN
eurjchem-2615	179	27	iv	iv	NUM
eurjchem-2615	179	28	enzymes	enzyme	NOUN
eurjchem-2615	179	29	essential	essential	ADJ
eurjchem-2615	179	30	for	for	ADP
eurjchem-2615	179	31	dna	dna	NOUN
eurjchem-2615	179	32	replication	replication	NOUN
eurjchem-2615	179	33	and	and	CCONJ
eurjchem-2615	179	34	repair	repair	NOUN
eurjchem-2615	179	35	.	.	PUNCT
eurjchem-2615	180	1	over	over	ADP
eurjchem-2615	180	2	the	the	DET
eurjchem-2615	180	3	years	year	NOUN
eurjchem-2615	180	4	,	,	PUNCT
eurjchem-2615	180	5	quinolones	quinolone	NOUN
eurjchem-2615	180	6	have	have	AUX
eurjchem-2615	180	7	been	be	AUX
eurjchem-2615	180	8	extensively	extensively	ADV
eurjchem-2615	180	9	developed	develop	VERB
eurjchem-2615	180	10	and	and	CCONJ
eurjchem-2615	180	11	optimized	optimize	VERB
eurjchem-2615	180	12	,	,	PUNCT
eurjchem-2615	180	13	resulting	result	VERB
eurjchem-2615	180	14	in	in	ADP
eurjchem-2615	180	15	various	various	ADJ
eurjchem-2615	180	16	90	90	NUM
eurjchem-2615	180	17	zimo	zimo	ADJ
eurjchem-2615	180	18	and	and	CCONJ
eurjchem-2615	180	19	coghi	coghi	PROPN
eurjchem-2615	180	20	/	/	SYM
eurjchem-2615	180	21	european	european	PROPN
eurjchem-2615	180	22	journal	journal	PROPN
eurjchem-2615	180	23	of	of	ADP
eurjchem-2615	180	24	chemistry	chemistry	NOUN
eurjchem-2615	180	25	16	16	NUM
eurjchem-2615	180	26	(	(	PUNCT
eurjchem-2615	180	27	1	1	NUM
eurjchem-2615	180	28	)	)	PUNCT
eurjchem-2615	180	29	(	(	PUNCT
eurjchem-2615	180	30	2025	2025	NUM
eurjchem-2615	180	31	)	)	PUNCT
eurjchem-2615	180	32	83	83	NUM
eurjchem-2615	180	33	-	-	SYM
eurjchem-2615	180	34	96	96	NUM
eurjchem-2615	180	35	2025	2025	NUM
eurjchem-2615	180	36	–	–	PUNCT
eurjchem-2615	180	37	european	european	ADJ
eurjchem-2615	180	38	journal	journal	NOUN
eurjchem-2615	180	39	of	of	ADP
eurjchem-2615	180	40	chemistry	chemistry	NOUN
eurjchem-2615	180	41	–	–	PUNCT
eurjchem-2615	180	42	cc	cc	NOUN
eurjchem-2615	180	43	by	by	ADP
eurjchem-2615	180	44	nc	nc	PROPN
eurjchem-2615	180	45	–	–	PUNCT
eurjchem-2615	180	46	doi	doi	NOUN
eurjchem-2615	180	47	:	:	PUNCT
eurjchem-2615	180	48	10.5155	10.5155	NUM
eurjchem-2615	180	49	/	/	SYM
eurjchem-2615	180	50	eurjchem.16.1.83	eurjchem.16.1.83	ADJ
eurjchem-2615	180	51	-	-	PUNCT
eurjchem-2615	180	52	96.2615	96.2615	NUM
eurjchem-2615	180	53	figure	figure	NOUN
eurjchem-2615	180	54	8	8	NUM
eurjchem-2615	180	55	.	.	PUNCT
eurjchem-2615	181	1	structure	structure	NOUN
eurjchem-2615	181	2	of	of	ADP
eurjchem-2615	181	3	some	some	DET
eurjchem-2615	181	4	1,2,3	1,2,3	NUM
eurjchem-2615	181	5	-	-	PUNCT
eurjchem-2615	181	6	triazole	triazole	ADJ
eurjchem-2615	181	7	-	-	PUNCT
eurjchem-2615	181	8	quinolone	quinolone	NOUN
eurjchem-2615	181	9	hybrids	hybrid	NOUN
eurjchem-2615	181	10	17	17	NUM
eurjchem-2615	181	11	-	-	SYM
eurjchem-2615	181	12	22	22	NUM
eurjchem-2615	181	13	as	as	ADP
eurjchem-2615	181	14	potential	potential	ADJ
eurjchem-2615	181	15	anti	anti	ADJ
eurjchem-2615	181	16	-	-	ADJ
eurjchem-2615	181	17	tb	tb	ADP
eurjchem-2615	181	18	activity	activity	NOUN
eurjchem-2615	181	19	.	.	PUNCT
eurjchem-2615	182	1	n	n	CCONJ
eurjchem-2615	183	1	r	r	NOUN
eurjchem-2615	183	2	n	n	NOUN
eurjchem-2615	183	3	o	o	NOUN
eurjchem-2615	183	4	o	o	X
eurjchem-2615	183	5	nn	nn	INTJ
eurjchem-2615	183	6	1	1	NUM
eurjchem-2615	183	7	25	25	NUM
eurjchem-2615	183	8	n	n	NOUN
eurjchem-2615	183	9	r	r	NOUN
eurjchem-2615	183	10	n	n	NOUN
eurjchem-2615	183	11	o	o	NOUN
eurjchem-2615	183	12	o	o	X
eurjchem-2615	183	13	nn	nn	INTJ
eurjchem-2615	183	14	1	1	NUM
eurjchem-2615	183	15	o	o	PROPN
eurjchem-2615	183	16	fe	fe	X
eurjchem-2615	183	17	fe	fe	X
eurjchem-2615	183	18	o26	o26	PROPN
eurjchem-2615	183	19	n	n	CCONJ
eurjchem-2615	183	20	n	n	CCONJ
eurjchem-2615	183	21	nn	nn	PROPN
eurjchem-2615	183	22	1	1	NUM
eurjchem-2615	183	23	27	27	NUM
eurjchem-2615	183	24	fehn	fehn	NOUN
eurjchem-2615	183	25	o	o	NOUN
eurjchem-2615	183	26	o	o	NOUN
eurjchem-2615	183	27	r	r	NOUN
eurjchem-2615	183	28	n	n	NOUN
eurjchem-2615	183	29	=	=	SYM
eurjchem-2615	183	30	2,3,4,5,6,8	2,3,4,5,6,8	NUM
eurjchem-2615	183	31	27a	27a	NUM
eurjchem-2615	183	32	:	:	PUNCT
eurjchem-2615	183	33	r	r	X
eurjchem-2615	183	34	=	=	SYM
eurjchem-2615	183	35	br	br	NOUN
eurjchem-2615	183	36	,	,	PUNCT
eurjchem-2615	183	37	n=2	n=2	PART
eurjchem-2615	183	38	27b	27b	NUM
eurjchem-2615	183	39	:	:	PUNCT
eurjchem-2615	184	1	r	r	X
eurjchem-2615	184	2	=	=	SYM
eurjchem-2615	184	3	br	br	NOUN
eurjchem-2615	184	4	,	,	PUNCT
eurjchem-2615	184	5	n=6	n=6	NOUN
eurjchem-2615	184	6	n	n	CCONJ
eurjchem-2615	184	7	nn	nn	PROPN
eurjchem-2615	184	8	1	1	NUM
eurjchem-2615	184	9	o	o	NOUN
eurjchem-2615	184	10	fe	fe	X
eurjchem-2615	184	11	o	o	NOUN
eurjchem-2615	184	12	28	28	NUM
eurjchem-2615	184	13	n	n	PROPN
eurjchem-2615	184	14	=	=	SYM
eurjchem-2615	184	15	2,3,4,5,6,8	2,3,4,5,6,8	NUM
eurjchem-2615	184	16	h	h	NOUN
eurjchem-2615	184	17	n	n	NOUN
eurjchem-2615	185	1	hn	hn	NOUN
eurjchem-2615	185	2	o	o	X
eurjchem-2615	185	3	o	o	NOUN
eurjchem-2615	185	4	r	r	NOUN
eurjchem-2615	185	5	figure	figure	NOUN
eurjchem-2615	185	6	9	9	NUM
eurjchem-2615	185	7	.	.	PUNCT
eurjchem-2615	185	8	structure	structure	NOUN
eurjchem-2615	185	9	of	of	ADP
eurjchem-2615	185	10	some	some	DET
eurjchem-2615	185	11	antitubercular	antitubercular	ADJ
eurjchem-2615	185	12	active	active	ADJ
eurjchem-2615	185	13	1,2,3	1,2,3	NUM
eurjchem-2615	185	14	-	-	ADJ
eurjchem-2615	185	15	triazole	triazole	ADJ
eurjchem-2615	185	16	-	-	PUNCT
eurjchem-2615	185	17	ferrocene	ferrocene	NOUN
eurjchem-2615	185	18	hybrids	hybrid	NOUN
eurjchem-2615	185	19	25	25	NUM
eurjchem-2615	185	20	-	-	SYM
eurjchem-2615	185	21	28	28	NUM
eurjchem-2615	185	22	.	.	PUNCT
eurjchem-2615	186	1	generations	generation	NOUN
eurjchem-2615	186	2	that	that	PRON
eurjchem-2615	186	3	address	address	VERB
eurjchem-2615	186	4	gram	gram	NOUN
eurjchem-2615	186	5	-	-	PUNCT
eurjchem-2615	186	6	positive	positive	ADJ
eurjchem-2615	186	7	and	and	CCONJ
eurjchem-2615	186	8	gram	gram	NOUN
eurjchem-2615	186	9	-	-	PUNCT
eurjchem-2615	186	10	negative	negative	ADJ
eurjchem-2615	186	11	bacteria	bacteria	NOUN
eurjchem-2615	186	12	[	[	X
eurjchem-2615	186	13	72	72	NUM
eurjchem-2615	186	14	]	]	PUNCT
eurjchem-2615	186	15	.	.	PUNCT
eurjchem-2615	187	1	their	their	PRON
eurjchem-2615	187	2	versatility	versatility	NOUN
eurjchem-2615	187	3	and	and	CCONJ
eurjchem-2615	187	4	effectiveness	effectiveness	NOUN
eurjchem-2615	187	5	have	have	AUX
eurjchem-2615	187	6	established	establish	VERB
eurjchem-2615	187	7	quinolones	quinolone	NOUN
eurjchem-2615	187	8	as	as	ADP
eurjchem-2615	187	9	valuable	valuable	ADJ
eurjchem-2615	187	10	agents	agent	NOUN
eurjchem-2615	187	11	in	in	ADP
eurjchem-2615	187	12	the	the	DET
eurjchem-2615	187	13	treatment	treatment	NOUN
eurjchem-2615	187	14	of	of	ADP
eurjchem-2615	187	15	respiratory	respiratory	ADJ
eurjchem-2615	187	16	,	,	PUNCT
eurjchem-2615	187	17	urinary	urinary	ADJ
eurjchem-2615	187	18	tract	tract	NOUN
eurjchem-2615	187	19	,	,	PUNCT
eurjchem-2615	187	20	gastrointestinal	gastrointestinal	ADJ
eurjchem-2615	187	21	,	,	PUNCT
eurjchem-2615	187	22	and	and	CCONJ
eurjchem-2615	187	23	skin	skin	NOUN
eurjchem-2615	187	24	infections	infection	NOUN
eurjchem-2615	187	25	,	,	PUNCT
eurjchem-2615	187	26	making	make	VERB
eurjchem-2615	187	27	them	they	PRON
eurjchem-2615	187	28	indispensable	indispensable	ADJ
eurjchem-2615	187	29	in	in	ADP
eurjchem-2615	187	30	modern	modern	ADJ
eurjchem-2615	187	31	antibiotic	antibiotic	ADJ
eurjchem-2615	187	32	therapy	therapy	NOUN
eurjchem-2615	187	33	.	.	PUNCT
eurjchem-2615	188	1	several	several	ADJ
eurjchem-2615	188	2	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2615	188	3	,	,	PUNCT
eurjchem-2615	188	4	including	include	VERB
eurjchem-2615	188	5	ciprofloxacin	ciprofloxacin	NOUN
eurjchem-2615	188	6	(	(	PUNCT
eurjchem-2615	188	7	cpfx	cpfx	NOUN
eurjchem-2615	188	8	)	)	PUNCT
eurjchem-2615	188	9	,	,	PUNCT
eurjchem-2615	188	10	ofloxacin	ofloxacin	NOUN
eurjchem-2615	188	11	,	,	PUNCT
eurjchem-2615	188	12	gatifloxacin	gatifloxacin	PROPN
eurjchem-2615	188	13	(	(	PUNCT
eurjchem-2615	188	14	gtfx	gtfx	PROPN
eurjchem-2615	188	15	)	)	PUNCT
eurjchem-2615	188	16	,	,	PUNCT
eurjchem-2615	188	17	moxifloxacin	moxifloxacin	NUM
eurjchem-2615	188	18	(	(	PUNCT
eurjchem-2615	188	19	mxfx	mxfx	NOUN
eurjchem-2615	188	20	)	)	PUNCT
eurjchem-2615	188	21	,	,	PUNCT
eurjchem-2615	188	22	and	and	CCONJ
eurjchem-2615	188	23	levofloxacin	levofloxacin	PROPN
eurjchem-2615	188	24	,	,	PUNCT
eurjchem-2615	188	25	have	have	AUX
eurjchem-2615	188	26	demonstrated	demonstrate	VERB
eurjchem-2615	188	27	exceptional	exceptional	ADJ
eurjchem-2615	188	28	activity	activity	NOUN
eurjchem-2615	188	29	profiles	profile	NOUN
eurjchem-2615	188	30	.	.	PUNCT
eurjchem-2615	189	1	some	some	PRON
eurjchem-2615	189	2	of	of	ADP
eurjchem-2615	189	3	these	these	DET
eurjchem-2615	189	4	compounds	compound	NOUN
eurjchem-2615	189	5	have	have	AUX
eurjchem-2615	189	6	been	be	AUX
eurjchem-2615	189	7	designated	designate	VERB
eurjchem-2615	189	8	by	by	ADP
eurjchem-2615	189	9	the	the	DET
eurjchem-2615	189	10	who	who	PRON
eurjchem-2615	189	11	as	as	ADP
eurjchem-2615	189	12	second	second	ADJ
eurjchem-2615	189	13	-	-	PUNCT
eurjchem-2615	189	14	line	line	NOUN
eurjchem-2615	189	15	treatments	treatment	NOUN
eurjchem-2615	189	16	for	for	ADP
eurjchem-2615	189	17	tuberculosis	tuberculosis	NOUN
eurjchem-2615	189	18	[	[	X
eurjchem-2615	189	19	73	73	NUM
eurjchem-2615	189	20	]	]	PUNCT
eurjchem-2615	189	21	.	.	PUNCT
eurjchem-2615	190	1	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2615	190	2	function	function	VERB
eurjchem-2615	190	3	by	by	ADP
eurjchem-2615	190	4	inhibiting	inhibit	VERB
eurjchem-2615	190	5	type	type	NOUN
eurjchem-2615	190	6	ii	ii	NOUN
eurjchem-2615	190	7	topoisomerases	topoisomerase	NOUN
eurjchem-2615	190	8	(	(	PUNCT
eurjchem-2615	190	9	specifically	specifically	ADV
eurjchem-2615	190	10	topoisomerase	topoisomerase	VERB
eurjchem-2615	190	11	iv	iv	NUM
eurjchem-2615	190	12	and	and	CCONJ
eurjchem-2615	190	13	dna	dna	PROPN
eurjchem-2615	190	14	gyrase	gyrase	NOUN
eurjchem-2615	190	15	)	)	PUNCT
eurjchem-2615	190	16	in	in	ADP
eurjchem-2615	190	17	bacteria	bacteria	NOUN
eurjchem-2615	190	18	,	,	PUNCT
eurjchem-2615	190	19	making	make	VERB
eurjchem-2615	190	20	them	they	PRON
eurjchem-2615	190	21	attractive	attractive	ADJ
eurjchem-2615	190	22	candidates	candidate	NOUN
eurjchem-2615	190	23	for	for	ADP
eurjchem-2615	190	24	antitubercular	antitubercular	ADJ
eurjchem-2615	190	25	drug	drug	NOUN
eurjchem-2615	190	26	development	development	NOUN
eurjchem-2615	190	27	[	[	X
eurjchem-2615	190	28	74	74	NUM
eurjchem-2615	190	29	]	]	PUNCT
eurjchem-2615	190	30	.	.	PUNCT
eurjchem-2615	191	1	since	since	SCONJ
eurjchem-2615	191	2	the	the	DET
eurjchem-2615	191	3	penetration	penetration	NOUN
eurjchem-2615	191	4	of	of	ADP
eurjchem-2615	191	5	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2615	191	6	in	in	ADP
eurjchem-2615	191	7	the	the	DET
eurjchem-2615	191	8	bacterial	bacterial	ADJ
eurjchem-2615	191	9	cell	cell	NOUN
eurjchem-2615	191	10	wall	wall	NOUN
eurjchem-2615	191	11	depends	depend	VERB
eurjchem-2615	191	12	on	on	ADP
eurjchem-2615	191	13	lipophilicity	lipophilicity	NOUN
eurjchem-2615	191	14	,	,	PUNCT
eurjchem-2615	191	15	enhancing	enhance	VERB
eurjchem-2615	191	16	the	the	DET
eurjchem-2615	191	17	lipophilic	lipophilic	ADJ
eurjchem-2615	191	18	character	character	NOUN
eurjchem-2615	191	19	in	in	ADP
eurjchem-2615	191	20	position	position	NOUN
eurjchem-2615	191	21	c-7	c-7	NOUN
eurjchem-2615	191	22	can	can	AUX
eurjchem-2615	191	23	lead	lead	VERB
eurjchem-2615	191	24	to	to	ADP
eurjchem-2615	191	25	improved	improve	VERB
eurjchem-2615	191	26	antitubercular	antitubercular	ADJ
eurjchem-2615	191	27	activity	activity	NOUN
eurjchem-2615	191	28	[	[	X
eurjchem-2615	191	29	75	75	NUM
eurjchem-2615	191	30	]	]	PUNCT
eurjchem-2615	191	31	.	.	PUNCT
eurjchem-2615	192	1	given	give	VERB
eurjchem-2615	192	2	the	the	DET
eurjchem-2615	192	3	notable	notable	ADJ
eurjchem-2615	192	4	characteristics	characteristic	NOUN
eurjchem-2615	192	5	of	of	ADP
eurjchem-2615	192	6	1,2,3	1,2,3	NUM
eurjchem-2615	192	7	-	-	ADJ
eurjchem-2615	192	8	triazole	triazole	NOUN
eurjchem-2615	192	9	rings	ring	NOUN
eurjchem-2615	192	10	under	under	ADP
eurjchem-2615	192	11	physiological	physiological	ADJ
eurjchem-2615	192	12	conditions	condition	NOUN
eurjchem-2615	192	13	,	,	PUNCT
eurjchem-2615	192	14	combining	combine	VERB
eurjchem-2615	192	15	this	this	DET
eurjchem-2615	192	16	framework	framework	NOUN
eurjchem-2615	192	17	with	with	ADP
eurjchem-2615	192	18	quinolones	quinolone	NOUN
eurjchem-2615	192	19	offers	offer	VERB
eurjchem-2615	192	20	potential	potential	NOUN
eurjchem-2615	192	21	for	for	ADP
eurjchem-2615	192	22	the	the	DET
eurjchem-2615	192	23	development	development	NOUN
eurjchem-2615	192	24	of	of	ADP
eurjchem-2615	192	25	antitubercular	antitubercular	ADJ
eurjchem-2615	192	26	drug	drug	NOUN
eurjchem-2615	192	27	candidates	candidate	NOUN
eurjchem-2615	192	28	with	with	ADP
eurjchem-2615	192	29	improved	improved	ADJ
eurjchem-2615	192	30	therapeutic	therapeutic	ADJ
eurjchem-2615	192	31	efficacy	efficacy	NOUN
eurjchem-2615	192	32	(	(	PUNCT
eurjchem-2615	192	33	figure	figure	NOUN
eurjchem-2615	192	34	8)	8)	NUM
eurjchem-2615	192	35	.	.	PUNCT
eurjchem-2615	193	1	for	for	ADP
eurjchem-2615	193	2	example	example	NOUN
eurjchem-2615	193	3	,	,	PUNCT
eurjchem-2615	193	4	compound	compound	NOUN
eurjchem-2615	193	5	19	19	NUM
eurjchem-2615	193	6	,	,	PUNCT
eurjchem-2615	193	7	which	which	PRON
eurjchem-2615	193	8	features	feature	VERB
eurjchem-2615	193	9	a	a	DET
eurjchem-2615	193	10	methyl	methyl	NOUN
eurjchem-2615	193	11	group	group	NOUN
eurjchem-2615	193	12	at	at	ADP
eurjchem-2615	193	13	the	the	DET
eurjchem-2615	193	14	n-9	n-9	PROPN
eurjchem-2615	193	15	position	position	NOUN
eurjchem-2615	193	16	,	,	PUNCT
eurjchem-2615	193	17	demonstrated	demonstrate	VERB
eurjchem-2615	193	18	significant	significant	ADJ
eurjchem-2615	193	19	in	in	ADP
eurjchem-2615	193	20	vitro	vitro	X
eurjchem-2615	193	21	antituberculosis	antituberculosis	NOUN
eurjchem-2615	193	22	activity	activity	NOUN
eurjchem-2615	193	23	(	(	PUNCT
eurjchem-2615	193	24	mic	mic	ADJ
eurjchem-2615	193	25	:	:	PUNCT
eurjchem-2615	193	26	0.5	0.5	NUM
eurjchem-2615	193	27	μg	μg	NOUN
eurjchem-2615	193	28	/	/	SYM
eurjchem-2615	193	29	ml	ml	NOUN
eurjchem-2615	193	30	)	)	PUNCT
eurjchem-2615	193	31	against	against	ADP
eurjchem-2615	193	32	both	both	DET
eurjchem-2615	193	33	m.	m.	NOUN
eurjchem-2615	193	34	tuberculosis	tuberculosis	ADP
eurjchem-2615	193	35	h37rv	h37rv	PROPN
eurjchem-2615	193	36	and	and	CCONJ
eurjchem-2615	193	37	h37ra	h37ra	PROPN
eurjchem-2615	193	38	strains	strain	NOUN
eurjchem-2615	193	39	,	,	PUNCT
eurjchem-2615	193	40	while	while	SCONJ
eurjchem-2615	193	41	showing	show	VERB
eurjchem-2615	193	42	a	a	DET
eurjchem-2615	193	43	favorable	favorable	ADJ
eurjchem-2615	193	44	cytotoxicity	cytotoxicity	NOUN
eurjchem-2615	193	45	profile	profile	NOUN
eurjchem-2615	193	46	against	against	ADP
eurjchem-2615	193	47	mt4	mt4	NOUN
eurjchem-2615	193	48	cells	cell	NOUN
eurjchem-2615	193	49	(	(	PUNCT
eurjchem-2615	193	50	cc50	cc50	PROPN
eurjchem-2615	193	51	>	>	X
eurjchem-2615	193	52	100	100	NUM
eurjchem-2615	193	53	μg	μg	NOUN
eurjchem-2615	193	54	/	/	SYM
eurjchem-2615	193	55	ml	ml	NOUN
eurjchem-2615	193	56	)	)	PUNCT
eurjchem-2615	193	57	.	.	PUNCT
eurjchem-2615	194	1	1h-1,2,3	1h-1,2,3	NUM
eurjchem-2615	194	2	-	-	PUNCT
eurjchem-2615	194	3	triazole	triazole	NOUN
eurjchem-2615	194	4	-	-	PUNCT
eurjchem-2615	194	5	linked	link	VERB
eurjchem-2615	194	6	8	8	NUM
eurjchem-2615	194	7	-	-	PUNCT
eurjchem-2615	194	8	ome	ome	NOUN
eurjchem-2615	194	9	-	-	PUNCT
eurjchem-2615	194	10	cpfx	cpfx	NOUN
eurjchem-2615	194	11	-	-	PUNCT
eurjchem-2615	194	12	isatin	isatin	NOUN
eurjchem-2615	194	13	hybrids	hybrid	NOUN
eurjchem-2615	194	14	20	20	NUM
eurjchem-2615	194	15	showed	show	VERB
eurjchem-2615	194	16	enhanced	enhanced	ADJ
eurjchem-2615	194	17	activity	activity	NOUN
eurjchem-2615	194	18	against	against	ADP
eurjchem-2615	194	19	both	both	PRON
eurjchem-2615	194	20	mtb	mtb	NOUN
eurjchem-2615	194	21	-	-	PUNCT
eurjchem-2615	194	22	h37rv	h37rv	NOUN
eurjchem-2615	194	23	and	and	CCONJ
eurjchem-2615	194	24	mdrtb	mdrtb	NOUN
eurjchem-2615	194	25	compared	compare	VERB
eurjchem-2615	194	26	to	to	ADP
eurjchem-2615	194	27	ciprofloxacin	ciprofloxacin	PROPN
eurjchem-2615	194	28	(	(	PUNCT
eurjchem-2615	194	29	cpfx	cpfx	NOUN
eurjchem-2615	194	30	)	)	PUNCT
eurjchem-2615	194	31	,	,	PUNCT
eurjchem-2615	194	32	8	8	NUM
eurjchem-2615	194	33	-	-	PUNCT
eurjchem-2615	194	34	ome	ome	NOUN
eurjchem-2615	194	35	-	-	PUNCT
eurjchem-2615	194	36	cpfx	cpfx	NOUN
eurjchem-2615	194	37	and	and	CCONJ
eurjchem-2615	194	38	rifampicin	rifampicin	VERB
eurjchem-2615	194	39	(	(	PUNCT
eurjchem-2615	194	40	rif	rif	PROPN
eurjchem-2615	194	41	)	)	PUNCT
eurjchem-2615	194	42	.	.	PUNCT
eurjchem-2615	195	1	sar	sar	PROPN
eurjchem-2615	195	2	studies	study	NOUN
eurjchem-2615	195	3	revealed	reveal	VERB
eurjchem-2615	195	4	that	that	SCONJ
eurjchem-2615	195	5	the	the	DET
eurjchem-2615	195	6	c-5	c-5	NOUN
eurjchem-2615	195	7	substituents	substituent	NOUN
eurjchem-2615	195	8	on	on	ADP
eurjchem-2615	195	9	isatin	isatin	PROPN
eurjchem-2615	195	10	followed	follow	VERB
eurjchem-2615	195	11	the	the	DET
eurjchem-2615	195	12	potency	potency	NOUN
eurjchem-2615	195	13	order	order	NOUN
eurjchem-2615	195	14	-f	-f	NUM
eurjchem-2615	195	15	>	>	PUNCT
eurjchem-2615	195	16	-h	-h	PUNCT
eurjchem-2615	195	17	>	>	X
eurjchem-2615	195	18	-me	-me	PROPN
eurjchem-2615	195	19	>	>	X
eurjchem-2615	195	20	-ome	-ome	PUNCT
eurjchem-2615	195	21	,	,	PUNCT
eurjchem-2615	195	22	while	while	SCONJ
eurjchem-2615	195	23	for	for	ADP
eurjchem-2615	195	24	the	the	DET
eurjchem-2615	195	25	imine	imine	NOUN
eurjchem-2615	195	26	/	/	SYM
eurjchem-2615	195	27	carbonyl	carbonyl	NOUN
eurjchem-2615	195	28	position	position	NOUN
eurjchem-2615	195	29	,	,	PUNCT
eurjchem-2615	195	30	methyloxime	methyloxime	PROPN
eurjchem-2615	195	31	≥	≥	PROPN
eurjchem-2615	195	32	ethyloxime	ethyloxime	PROPN
eurjchem-2615	195	33	>	>	X
eurjchem-2615	195	34	carbonyl	carbonyl	NOUN
eurjchem-2615	195	35	group	group	NOUN
eurjchem-2615	195	36	.	.	PUNCT
eurjchem-2615	196	1	hybrid	hybrid	NOUN
eurjchem-2615	196	2	21	21	NUM
eurjchem-2615	196	3	demonstrated	demonstrate	VERB
eurjchem-2615	196	4	significantly	significantly	ADV
eurjchem-2615	196	5	higher	high	ADJ
eurjchem-2615	196	6	activity	activity	NOUN
eurjchem-2615	196	7	than	than	ADP
eurjchem-2615	196	8	cpfx	cpfx	NOUN
eurjchem-2615	196	9	and	and	CCONJ
eurjchem-2615	196	10	8	8	NUM
eurjchem-2615	196	11	-	-	PUNCT
eurjchem-2615	196	12	ome	ome	NOUN
eurjchem-2615	196	13	-	-	PUNCT
eurjchem-2615	196	14	cpfx	cpfx	NOUN
eurjchem-2615	196	15	,	,	PUNCT
eurjchem-2615	196	16	matching	match	VERB
eurjchem-2615	196	17	rif	rif	PROPN
eurjchem-2615	196	18	’s	’s	PART
eurjchem-2615	196	19	potency	potency	NOUN
eurjchem-2615	196	20	.	.	PUNCT
eurjchem-2615	197	1	zimo	zimo	VERB
eurjchem-2615	197	2	and	and	CCONJ
eurjchem-2615	197	3	coghi	coghi	PROPN
eurjchem-2615	197	4	/	/	SYM
eurjchem-2615	197	5	european	european	PROPN
eurjchem-2615	197	6	journal	journal	PROPN
eurjchem-2615	197	7	of	of	ADP
eurjchem-2615	197	8	chemistry	chemistry	NOUN
eurjchem-2615	197	9	16	16	NUM
eurjchem-2615	197	10	(	(	PUNCT
eurjchem-2615	197	11	1	1	NUM
eurjchem-2615	197	12	)	)	PUNCT
eurjchem-2615	197	13	(	(	PUNCT
eurjchem-2615	197	14	2025	2025	NUM
eurjchem-2615	197	15	)	)	PUNCT
eurjchem-2615	197	16	83	83	NUM
eurjchem-2615	197	17	-	-	SYM
eurjchem-2615	197	18	96	96	NUM
eurjchem-2615	197	19	91	91	NUM
eurjchem-2615	197	20	2025	2025	NUM
eurjchem-2615	197	21	–	–	PUNCT
eurjchem-2615	197	22	european	european	ADJ
eurjchem-2615	197	23	journal	journal	NOUN
eurjchem-2615	197	24	of	of	ADP
eurjchem-2615	197	25	chemistry	chemistry	NOUN
eurjchem-2615	197	26	–	–	PUNCT
eurjchem-2615	197	27	cc	cc	NOUN
eurjchem-2615	197	28	by	by	ADP
eurjchem-2615	197	29	nc	nc	PROPN
eurjchem-2615	197	30	–	–	PUNCT
eurjchem-2615	197	31	doi	doi	NOUN
eurjchem-2615	197	32	:	:	PUNCT
eurjchem-2615	197	33	10.5155	10.5155	NUM
eurjchem-2615	197	34	/	/	SYM
eurjchem-2615	197	35	eurjchem.16.1.83	eurjchem.16.1.83	ADJ
eurjchem-2615	197	36	-	-	PUNCT
eurjchem-2615	197	37	96.2615	96.2615	NUM
eurjchem-2615	197	38	n	n	NUM
eurjchem-2615	197	39	h	h	NOUN
eurjchem-2615	197	40	n	n	ADP
eurjchem-2615	197	41	o	o	NOUN
eurjchem-2615	197	42	o	o	X
eurjchem-2615	197	43	n	n	CCONJ
eurjchem-2615	197	44	n	n	CCONJ
eurjchem-2615	197	45	n	n	NOUN
eurjchem-2615	197	46	r	r	NOUN
eurjchem-2615	197	47	29	29	NUM
eurjchem-2615	197	48	29a	29a	NUM
eurjchem-2615	197	49	:	:	PUNCT
eurjchem-2615	197	50	r=4	r=4	PROPN
eurjchem-2615	197	51	-	-	ADJ
eurjchem-2615	197	52	f	f	NOUN
eurjchem-2615	197	53	-	-	PUNCT
eurjchem-2615	197	54	c6h4	c6h4	NOUN
eurjchem-2615	197	55	29b	29b	NOUN
eurjchem-2615	197	56	:	:	PUNCT
eurjchem-2615	197	57	r=4	r=4	PROPN
eurjchem-2615	197	58	-	-	NOUN
eurjchem-2615	197	59	cl	cl	NOUN
eurjchem-2615	197	60	-	-	PUNCT
eurjchem-2615	197	61	c6h4	c6h4	NOUN
eurjchem-2615	197	62	29c	29c	NOUN
eurjchem-2615	197	63	:	:	PUNCT
eurjchem-2615	197	64	r=4	r=4	PROPN
eurjchem-2615	197	65	-	-	NOUN
eurjchem-2615	197	66	cf3	cf3	NOUN
eurjchem-2615	197	67	-	-	PUNCT
eurjchem-2615	197	68	c6h4	c6h4	NOUN
eurjchem-2615	197	69	29d	29d	NUM
eurjchem-2615	197	70	:	:	PUNCT
eurjchem-2615	197	71	r=3	r=3	PROPN
eurjchem-2615	197	72	-	-	PUNCT
eurjchem-2615	197	73	cf3	cf3	NOUN
eurjchem-2615	197	74	-	-	PUNCT
eurjchem-2615	197	75	c6h4	c6h4	NOUN
eurjchem-2615	197	76	n	n	NOUN
eurjchem-2615	197	77	r	r	NOUN
eurjchem-2615	197	78	o	o	X
eurjchem-2615	197	79	x	x	X
eurjchem-2615	197	80	n	n	CCONJ
eurjchem-2615	197	81	n	n	CCONJ
eurjchem-2615	197	82	n	n	NOUN
eurjchem-2615	197	83	x	x	SYM
eurjchem-2615	197	84	30	30	NUM
eurjchem-2615	197	85	30a	30a	NUM
eurjchem-2615	197	86	:	:	PUNCT
eurjchem-2615	197	87	x	x	X
eurjchem-2615	197	88	=	=	NOUN
eurjchem-2615	197	89	inh	inh	NOUN
eurjchem-2615	197	90	,	,	PUNCT
eurjchem-2615	197	91	r	r	NOUN
eurjchem-2615	197	92	=	=	NOUN
eurjchem-2615	197	93	cl	cl	NOUN
eurjchem-2615	197	94	30b	30b	NOUN
eurjchem-2615	197	95	:	:	PUNCT
eurjchem-2615	197	96	x	x	X
eurjchem-2615	197	97	=	=	NOUN
eurjchem-2615	197	98	inh	inh	NOUN
eurjchem-2615	197	99	,	,	PUNCT
eurjchem-2615	197	100	r	r	NOUN
eurjchem-2615	197	101	=	=	SYM
eurjchem-2615	197	102	ome	ome	NOUN
eurjchem-2615	197	103	n	n	NUM
eurjchem-2615	197	104	o	o	NOUN
eurjchem-2615	197	105	o	o	X
eurjchem-2615	197	106	n	n	CCONJ
eurjchem-2615	197	107	n	n	CCONJ
eurjchem-2615	197	108	n	n	ADV
eurjchem-2615	197	109	r1	r1	PROPN
eurjchem-2615	197	110	r2	r2	PROPN
eurjchem-2615	197	111	r3	r3	PROPN
eurjchem-2615	197	112	31	31	NUM
eurjchem-2615	197	113	31a	31a	NUM
eurjchem-2615	197	114	:	:	PUNCT
eurjchem-2615	197	115	r1	r1	PROPN
eurjchem-2615	197	116	=	=	SYM
eurjchem-2615	197	117	h	h	PROPN
eurjchem-2615	197	118	,	,	PUNCT
eurjchem-2615	197	119	r2	r2	PROPN
eurjchem-2615	197	120	=	=	SYM
eurjchem-2615	197	121	no2	no2	PROPN
eurjchem-2615	197	122	,	,	PUNCT
eurjchem-2615	197	123	r3	r3	PROPN
eurjchem-2615	197	124	=	=	NOUN
eurjchem-2615	197	125	no2	no2	NOUN
eurjchem-2615	197	126	31b	31b	NUM
eurjchem-2615	197	127	:	:	PUNCT
eurjchem-2615	197	128	r1	r1	PROPN
eurjchem-2615	197	129	=	=	SYM
eurjchem-2615	197	130	h	h	PROPN
eurjchem-2615	197	131	,	,	PUNCT
eurjchem-2615	197	132	r2	r2	PROPN
eurjchem-2615	197	133	=	=	SYM
eurjchem-2615	197	134	h	h	NOUN
eurjchem-2615	197	135	,	,	PUNCT
eurjchem-2615	197	136	r3	r3	PROPN
eurjchem-2615	197	137	=	=	NOUN
eurjchem-2615	197	138	br	br	NOUN
eurjchem-2615	197	139	n	n	ADV
eurjchem-2615	197	140	o	o	NOUN
eurjchem-2615	197	141	o	o	X
eurjchem-2615	197	142	n	n	CCONJ
eurjchem-2615	197	143	n	n	CCONJ
eurjchem-2615	197	144	n	n	NOUN
eurjchem-2615	198	1	o	o	NOUN
eurjchem-2615	199	1	o	o	X
eurjchem-2615	199	2	o	o	X
eurjchem-2615	199	3	o	o	X
eurjchem-2615	199	4	nome	nome	PROPN
eurjchem-2615	199	5	f	f	PROPN
eurjchem-2615	199	6	32	32	NUM
eurjchem-2615	199	7	figure	figure	NOUN
eurjchem-2615	199	8	10	10	NUM
eurjchem-2615	199	9	.	.	PUNCT
eurjchem-2615	200	1	1,2,3	1,2,3	NUM
eurjchem-2615	200	2	-	-	ADJ
eurjchem-2615	200	3	triazole	triazole	NOUN
eurjchem-2615	200	4	-	-	PUNCT
eurjchem-2615	200	5	isatin	isatin	NOUN
eurjchem-2615	200	6	hybrids	hybrid	NOUN
eurjchem-2615	200	7	as	as	ADP
eurjchem-2615	200	8	a	a	DET
eurjchem-2615	200	9	potent	potent	ADJ
eurjchem-2615	200	10	antitubercular	antitubercular	ADJ
eurjchem-2615	200	11	agent	agent	NOUN
eurjchem-2615	200	12	29	29	NUM
eurjchem-2615	200	13	-	-	SYM
eurjchem-2615	200	14	32	32	NUM
eurjchem-2615	200	15	.	.	PUNCT
eurjchem-2615	201	1	the	the	DET
eurjchem-2615	201	2	derivative	derivative	ADJ
eurjchem-2615	201	3	22	22	NUM
eurjchem-2615	201	4	showed	show	VERB
eurjchem-2615	201	5	that	that	SCONJ
eurjchem-2615	201	6	replacing	replace	VERB
eurjchem-2615	201	7	8	8	NUM
eurjchem-2615	201	8	-	-	PUNCT
eurjchem-2615	201	9	ome	ome	NOUN
eurjchem-2615	201	10	with	with	ADP
eurjchem-2615	201	11	h	h	NOUN
eurjchem-2615	201	12	on	on	ADP
eurjchem-2615	201	13	the	the	DET
eurjchem-2615	201	14	cpfx	cpfx	NOUN
eurjchem-2615	201	15	moiety	moiety	NOUN
eurjchem-2615	201	16	maintained	maintain	VERB
eurjchem-2615	201	17	similar	similar	ADJ
eurjchem-2615	201	18	activity	activity	NOUN
eurjchem-2615	201	19	levels	level	NOUN
eurjchem-2615	201	20	[	[	X
eurjchem-2615	201	21	76	76	NUM
eurjchem-2615	201	22	-	-	SYM
eurjchem-2615	201	23	78	78	NUM
eurjchem-2615	201	24	]	]	PUNCT
eurjchem-2615	201	25	.	.	PUNCT
eurjchem-2615	202	1	compound	compound	NOUN
eurjchem-2615	202	2	23	23	NUM
eurjchem-2615	202	3	showed	show	VERB
eurjchem-2615	202	4	comparable	comparable	ADJ
eurjchem-2615	202	5	potency	potency	NOUN
eurjchem-2615	202	6	to	to	ADP
eurjchem-2615	202	7	first	first	ADJ
eurjchem-2615	202	8	-	-	PUNCT
eurjchem-2615	202	9	line	line	NOUN
eurjchem-2615	202	10	anti	anti	ADJ
eurjchem-2615	202	11	-	-	ADJ
eurjchem-2615	202	12	tb	tb	ADJ
eurjchem-2615	202	13	drugs	drug	NOUN
eurjchem-2615	202	14	against	against	ADP
eurjchem-2615	202	15	mtb	mtb	NOUN
eurjchem-2615	202	16	-	-	PUNCT
eurjchem-2615	202	17	h37rv	h37rv	PROPN
eurjchem-2615	202	18	and	and	CCONJ
eurjchem-2615	202	19	demonstrated	demonstrate	VERB
eurjchem-2615	202	20	significantly	significantly	ADV
eurjchem-2615	202	21	higher	high	ADJ
eurjchem-2615	202	22	activity	activity	NOUN
eurjchem-2615	202	23	against	against	ADP
eurjchem-2615	202	24	mdr	mdr	PROPN
eurjchem-2615	202	25	-	-	PROPN
eurjchem-2615	202	26	tb	tb	PROPN
eurjchem-2615	202	27	,	,	PUNCT
eurjchem-2615	202	28	suggesting	suggest	VERB
eurjchem-2615	202	29	a	a	DET
eurjchem-2615	202	30	novel	novel	ADJ
eurjchem-2615	202	31	mechanism	mechanism	NOUN
eurjchem-2615	202	32	for	for	ADP
eurjchem-2615	202	33	treating	treat	VERB
eurjchem-2615	202	34	drug	drug	NOUN
eurjchem-2615	202	35	-	-	PUNCT
eurjchem-2615	202	36	resistant	resistant	ADJ
eurjchem-2615	202	37	tb	tb	NOUN
eurjchem-2615	202	38	.	.	PUNCT
eurjchem-2615	203	1	while	while	SCONJ
eurjchem-2615	203	2	these	these	DET
eurjchem-2615	203	3	hybrids	hybrid	NOUN
eurjchem-2615	203	4	maintained	maintain	VERB
eurjchem-2615	203	5	acceptable	acceptable	ADJ
eurjchem-2615	203	6	cytotoxicity	cytotoxicity	NOUN
eurjchem-2615	203	7	profiles	profile	NOUN
eurjchem-2615	203	8	,	,	PUNCT
eurjchem-2615	203	9	their	their	PRON
eurjchem-2615	203	10	toxicity	toxicity	NOUN
eurjchem-2615	203	11	was	be	AUX
eurjchem-2615	203	12	somewhat	somewhat	ADV
eurjchem-2615	203	13	higher	high	ADJ
eurjchem-2615	203	14	than	than	ADP
eurjchem-2615	203	15	that	that	PRON
eurjchem-2615	203	16	of	of	ADP
eurjchem-2615	203	17	ciprofloxacin	ciprofloxacin	PRON
eurjchem-2615	203	18	[	[	X
eurjchem-2615	203	19	79	79	NUM
eurjchem-2615	203	20	]	]	PUNCT
eurjchem-2615	203	21	.	.	PUNCT
eurjchem-2615	204	1	acetyl	acetyl	NOUN
eurjchem-2615	204	2	-	-	PUNCT
eurjchem-2615	204	3	linked	link	VERB
eurjchem-2615	204	4	gatifloxacin-1,2,3	gatifloxacin-1,2,3	NOUN
eurjchem-2615	204	5	-	-	PUNCT
eurjchem-2615	204	6	triazole	triazole	NOUN
eurjchem-2615	204	7	-	-	PUNCT
eurjchem-2615	204	8	isatin	isatin	NOUN
eurjchem-2615	204	9	hybrids	hybrid	NOUN
eurjchem-2615	204	10	24	24	NUM
eurjchem-2615	204	11	demonstrated	demonstrate	VERB
eurjchem-2615	204	12	strong	strong	ADJ
eurjchem-2615	204	13	activity	activity	NOUN
eurjchem-2615	204	14	against	against	ADP
eurjchem-2615	204	15	h37rv	h37rv	PROPN
eurjchem-2615	204	16	and	and	CCONJ
eurjchem-2615	204	17	two	two	NUM
eurjchem-2615	204	18	mdr	mdr	PROPN
eurjchem-2615	204	19	-	-	PUNCT
eurjchem-2615	204	20	mtb	mtb	ADJ
eurjchem-2615	204	21	strains	strain	NOUN
eurjchem-2615	204	22	:	:	PUNCT
eurjchem-2615	204	23	mdrmtb1	mdrmtb1	PROPN
eurjchem-2615	204	24	and	and	CCONJ
eurjchem-2615	204	25	mdr	mdr	PROPN
eurjchem-2615	204	26	-	-	PROPN
eurjchem-2615	204	27	mtb2	mtb2	PROPN
eurjchem-2615	204	28	,	,	PUNCT
eurjchem-2615	204	29	showing	show	VERB
eurjchem-2615	204	30	favorable	favorable	ADJ
eurjchem-2615	204	31	activity	activity	NOUN
eurjchem-2615	204	32	profiles	profile	NOUN
eurjchem-2615	204	33	compared	compare	VERB
eurjchem-2615	204	34	to	to	ADP
eurjchem-2615	204	35	the	the	DET
eurjchem-2615	204	36	reference	reference	NOUN
eurjchem-2615	204	37	compounds	compound	VERB
eurjchem-2615	204	38	gatifloxacin	gatifloxacin	PROPN
eurjchem-2615	204	39	(	(	PUNCT
eurjchem-2615	204	40	gtfx	gtfx	PROPN
eurjchem-2615	204	41	)	)	PUNCT
eurjchem-2615	204	42	,	,	PUNCT
eurjchem-2615	204	43	rifampicin	rifampicin	VERB
eurjchem-2615	204	44	(	(	PUNCT
eurjchem-2615	204	45	rif	rif	PROPN
eurjchem-2615	204	46	)	)	PUNCT
eurjchem-2615	204	47	,	,	PUNCT
eurjchem-2615	204	48	and	and	CCONJ
eurjchem-2615	204	49	isoniazid	isoniazid	NOUN
eurjchem-2615	204	50	(	(	PUNCT
eurjchem-2615	204	51	inh	inh	PROPN
eurjchem-2615	204	52	)	)	PUNCT
eurjchem-2615	205	1	[	[	X
eurjchem-2615	205	2	80	80	NUM
eurjchem-2615	205	3	]	]	PUNCT
eurjchem-2615	205	4	.	.	PUNCT
eurjchem-2615	206	1	4.6	4.6	NUM
eurjchem-2615	206	2	.	.	PUNCT
eurjchem-2615	207	1	1,2,3	1,2,3	NUM
eurjchem-2615	207	2	-	-	ADJ
eurjchem-2615	207	3	triazole	triazole	ADJ
eurjchem-2615	207	4	-	-	PUNCT
eurjchem-2615	207	5	ferrocene	ferrocene	NOUN
eurjchem-2615	207	6	hybrids	hybrid	NOUN
eurjchem-2615	207	7	ferrocene-1,2,3	ferrocene-1,2,3	ADJ
eurjchem-2615	207	8	-	-	ADJ
eurjchem-2615	207	9	triazole	triazole	ADJ
eurjchem-2615	207	10	hybrids	hybrid	NOUN
eurjchem-2615	207	11	offer	offer	VERB
eurjchem-2615	207	12	a	a	DET
eurjchem-2615	207	13	highly	highly	ADV
eurjchem-2615	207	14	promising	promising	ADJ
eurjchem-2615	207	15	approach	approach	NOUN
eurjchem-2615	207	16	to	to	ADP
eurjchem-2615	207	17	the	the	DET
eurjchem-2615	207	18	development	development	NOUN
eurjchem-2615	207	19	of	of	ADP
eurjchem-2615	207	20	new	new	ADJ
eurjchem-2615	207	21	antitubercular	antitubercular	ADJ
eurjchem-2615	207	22	drug	drug	NOUN
eurjchem-2615	207	23	candidates	candidate	NOUN
eurjchem-2615	207	24	.	.	PUNCT
eurjchem-2615	208	1	these	these	DET
eurjchem-2615	208	2	hybrid	hybrid	ADJ
eurjchem-2615	208	3	compounds	compound	NOUN
eurjchem-2615	208	4	leverage	leverage	VERB
eurjchem-2615	208	5	the	the	DET
eurjchem-2615	208	6	unique	unique	ADJ
eurjchem-2615	208	7	redox	redox	ADJ
eurjchem-2615	208	8	properties	property	NOUN
eurjchem-2615	208	9	of	of	ADP
eurjchem-2615	208	10	ferrocene	ferrocene	NOUN
eurjchem-2615	208	11	alongside	alongside	ADP
eurjchem-2615	208	12	the	the	DET
eurjchem-2615	208	13	bioactivity	bioactivity	NOUN
eurjchem-2615	208	14	of	of	ADP
eurjchem-2615	208	15	the	the	DET
eurjchem-2615	208	16	1,2,3triazole	1,2,3triazole	NUM
eurjchem-2615	208	17	ring	ring	NOUN
eurjchem-2615	208	18	,	,	PUNCT
eurjchem-2615	208	19	creating	create	VERB
eurjchem-2615	208	20	a	a	DET
eurjchem-2615	208	21	potent	potent	ADJ
eurjchem-2615	208	22	framework	framework	NOUN
eurjchem-2615	208	23	to	to	PART
eurjchem-2615	208	24	target	target	VERB
eurjchem-2615	208	25	mycobacterium	mycobacterium	NOUN
eurjchem-2615	208	26	tuberculosis	tuberculosis	NOUN
eurjchem-2615	208	27	.	.	PUNCT
eurjchem-2615	209	1	by	by	ADP
eurjchem-2615	209	2	combining	combine	VERB
eurjchem-2615	209	3	these	these	DET
eurjchem-2615	209	4	distinct	distinct	ADJ
eurjchem-2615	209	5	molecular	molecular	ADJ
eurjchem-2615	209	6	characteristics	characteristic	NOUN
eurjchem-2615	209	7	,	,	PUNCT
eurjchem-2615	209	8	ferrocene-1,2,3	ferrocene-1,2,3	ADJ
eurjchem-2615	209	9	-	-	ADJ
eurjchem-2615	209	10	triazole	triazole	ADJ
eurjchem-2615	209	11	hybrids	hybrid	NOUN
eurjchem-2615	209	12	have	have	AUX
eurjchem-2615	209	13	shown	show	VERB
eurjchem-2615	209	14	significant	significant	ADJ
eurjchem-2615	209	15	potential	potential	NOUN
eurjchem-2615	209	16	to	to	PART
eurjchem-2615	209	17	enhance	enhance	VERB
eurjchem-2615	209	18	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	209	19	activity	activity	NOUN
eurjchem-2615	209	20	,	,	PUNCT
eurjchem-2615	209	21	making	make	VERB
eurjchem-2615	209	22	them	they	PRON
eurjchem-2615	209	23	a	a	DET
eurjchem-2615	209	24	valuable	valuable	ADJ
eurjchem-2615	209	25	focus	focus	NOUN
eurjchem-2615	209	26	in	in	ADP
eurjchem-2615	209	27	the	the	DET
eurjchem-2615	209	28	search	search	NOUN
eurjchem-2615	209	29	for	for	ADP
eurjchem-2615	209	30	effective	effective	ADJ
eurjchem-2615	209	31	treatments	treatment	NOUN
eurjchem-2615	209	32	against	against	ADP
eurjchem-2615	209	33	tuberculosis	tuberculosis	NOUN
eurjchem-2615	209	34	,	,	PUNCT
eurjchem-2615	209	35	including	include	VERB
eurjchem-2615	209	36	drug	drug	NOUN
eurjchem-2615	209	37	resistant	resistant	ADJ
eurjchem-2615	209	38	strains	strain	NOUN
eurjchem-2615	209	39	(	(	PUNCT
eurjchem-2615	209	40	figure	figure	NOUN
eurjchem-2615	209	41	9	9	NUM
eurjchem-2615	209	42	)	)	PUNCT
eurjchem-2615	209	43	.	.	PUNCT
eurjchem-2615	210	1	compounds	compound	VERB
eurjchem-2615	210	2	25	25	NUM
eurjchem-2615	210	3	and	and	CCONJ
eurjchem-2615	210	4	26	26	NUM
eurjchem-2615	210	5	(	(	PUNCT
eurjchem-2615	210	6	mic	mic	ADJ
eurjchem-2615	210	7	:	:	PUNCT
eurjchem-2615	210	8	107	107	NUM
eurjchem-2615	210	9	-	-	SYM
eurjchem-2615	210	10	463	463	NUM
eurjchem-2615	210	11	μm	μm	NOUN
eurjchem-2615	210	12	)	)	PUNCT
eurjchem-2615	210	13	showed	show	VERB
eurjchem-2615	210	14	moderate	moderate	ADJ
eurjchem-2615	210	15	to	to	PART
eurjchem-2615	210	16	significant	significant	ADJ
eurjchem-2615	210	17	antitubercular	antitubercular	ADJ
eurjchem-2615	210	18	activity	activity	NOUN
eurjchem-2615	210	19	against	against	ADP
eurjchem-2615	210	20	m.	m.	NOUN
eurjchem-2615	210	21	tuberculosis	tuberculosis	NOUN
eurjchem-2615	210	22	mc2	mc2	PROPN
eurjchem-2615	210	23	7000	7000	NUM
eurjchem-2615	210	24	,	,	PUNCT
eurjchem-2615	210	25	compared	compare	VERB
eurjchem-2615	210	26	to	to	ADP
eurjchem-2615	210	27	the	the	DET
eurjchem-2615	210	28	standards	standard	NOUN
eurjchem-2615	210	29	ampicillin	ampicillin	NOUN
eurjchem-2615	210	30	,	,	PUNCT
eurjchem-2615	210	31	ethambutol	ethambutol	ADJ
eurjchem-2615	210	32	,	,	PUNCT
eurjchem-2615	210	33	isoniazid	isoniazid	NOUN
eurjchem-2615	210	34	,	,	PUNCT
eurjchem-2615	210	35	and	and	CCONJ
eurjchem-2615	210	36	rifampicin	rifampicin	VERB
eurjchem-2615	210	37	(	(	PUNCT
eurjchem-2615	210	38	mic	mic	ADJ
eurjchem-2615	210	39	:	:	PUNCT
eurjchem-2615	210	40	72	72	NUM
eurjchem-2615	210	41	-	-	SYM
eurjchem-2615	210	42	144	144	NUM
eurjchem-2615	210	43	,	,	PUNCT
eurjchem-2615	210	44	90.36	90.36	NUM
eurjchem-2615	210	45	,	,	PUNCT
eurjchem-2615	210	46	2.92	2.92	NUM
eurjchem-2615	210	47	,	,	PUNCT
eurjchem-2615	210	48	and	and	CCONJ
eurjchem-2615	210	49	0.12	0.12	NUM
eurjchem-2615	210	50	μm	μm	NUM
eurjchem-2615	210	51	,	,	PUNCT
eurjchem-2615	210	52	respectively	respectively	ADV
eurjchem-2615	210	53	)	)	PUNCT
eurjchem-2615	210	54	.	.	PUNCT
eurjchem-2615	211	1	the	the	DET
eurjchem-2615	211	2	studies	study	NOUN
eurjchem-2615	211	3	confirmed	confirm	VERB
eurjchem-2615	211	4	that	that	SCONJ
eurjchem-2615	211	5	isatin	isatin	PROPN
eurjchem-2615	211	6	moieties	moiety	NOUN
eurjchem-2615	211	7	contributed	contribute	VERB
eurjchem-2615	211	8	more	more	ADV
eurjchem-2615	211	9	positively	positively	ADV
eurjchem-2615	211	10	to	to	ADP
eurjchem-2615	211	11	activity	activity	NOUN
eurjchem-2615	211	12	than	than	ADP
eurjchem-2615	211	13	β	β	NOUN
eurjchem-2615	211	14	-	-	NOUN
eurjchem-2615	211	15	lactam	lactam	NOUN
eurjchem-2615	211	16	groups	group	NOUN
eurjchem-2615	211	17	[	[	X
eurjchem-2615	211	18	81	81	NUM
eurjchem-2615	211	19	]	]	PUNCT
eurjchem-2615	211	20	.	.	PUNCT
eurjchem-2615	212	1	the	the	DET
eurjchem-2615	212	2	1,2,3	1,2,3	NUM
eurjchem-2615	212	3	-	-	PUNCT
eurjchem-2615	212	4	triazole	triazole	NOUN
eurjchem-2615	212	5	-	-	PUNCT
eurjchem-2615	212	6	linked	link	VERB
eurjchem-2615	212	7	uracil	uracil	ADJ
eurjchem-2615	212	8	-	-	PUNCT
eurjchem-2615	212	9	ferrocene	ferrocene	NOUN
eurjchem-2615	212	10	hybrids	hybrid	NOUN
eurjchem-2615	212	11	27	27	NUM
eurjchem-2615	212	12	and	and	CCONJ
eurjchem-2615	212	13	28	28	NUM
eurjchem-2615	212	14	were	be	AUX
eurjchem-2615	212	15	generally	generally	ADV
eurjchem-2615	212	16	inactive	inactive	ADJ
eurjchem-2615	212	17	at	at	ADP
eurjchem-2615	212	18	50	50	NUM
eurjchem-2615	212	19	μg	μg	NOUN
eurjchem-2615	212	20	/	/	SYM
eurjchem-2615	212	21	ml	ml	NOUN
eurjchem-2615	212	22	,	,	PUNCT
eurjchem-2615	212	23	although	although	SCONJ
eurjchem-2615	212	24	ferrocene	ferrocene	NOUN
eurjchem-2615	212	25	improved	improved	ADJ
eurjchem-2615	212	26	activity	activity	NOUN
eurjchem-2615	212	27	compared	compare	VERB
eurjchem-2615	212	28	to	to	ADP
eurjchem-2615	212	29	nalkylazido	nalkylazido	NOUN
eurjchem-2615	212	30	-	-	PUNCT
eurjchem-2615	212	31	uracils	uracil	NOUN
eurjchem-2615	212	32	,	,	PUNCT
eurjchem-2615	212	33	while	while	SCONJ
eurjchem-2615	212	34	ferrocenyl	ferrocenyl	NOUN
eurjchem-2615	212	35	-	-	PUNCT
eurjchem-2615	212	36	chalcone	chalcone	NOUN
eurjchem-2615	212	37	decreased	decrease	VERB
eurjchem-2615	212	38	it	it	PRON
eurjchem-2615	212	39	.	.	PUNCT
eurjchem-2615	213	1	the	the	DET
eurjchem-2615	213	2	sar	sar	NOUN
eurjchem-2615	213	3	showed	show	VERB
eurjchem-2615	213	4	that	that	SCONJ
eurjchem-2615	213	5	activity	activity	NOUN
eurjchem-2615	213	6	depends	depend	VERB
eurjchem-2615	213	7	on	on	ADP
eurjchem-2615	213	8	c-5	c-5	NOUN
eurjchem-2615	213	9	substituents	substituent	NOUN
eurjchem-2615	213	10	and	and	CCONJ
eurjchem-2615	213	11	spacer	spacer	NOUN
eurjchem-2615	213	12	length	length	NOUN
eurjchem-2615	213	13	.	.	PUNCT
eurjchem-2615	214	1	compounds	compound	VERB
eurjchem-2615	214	2	25a	25a	NUM
eurjchem-2615	214	3	,	,	PUNCT
eurjchem-2615	214	4	b	b	NOUN
eurjchem-2615	214	5	,	,	PUNCT
eurjchem-2615	214	6	with	with	ADP
eurjchem-2615	214	7	c-5	c-5	NOUN
eurjchem-2615	214	8	bromine	bromine	NOUN
eurjchem-2615	214	9	and	and	CCONJ
eurjchem-2615	214	10	spacer	spacer	NOUN
eurjchem-2615	214	11	lengths	length	NOUN
eurjchem-2615	214	12	n	n	NOUN
eurjchem-2615	214	13	=	=	SYM
eurjchem-2615	214	14	2	2	NUM
eurjchem-2615	214	15	or	or	CCONJ
eurjchem-2615	214	16	6	6	NUM
eurjchem-2615	214	17	,	,	PUNCT
eurjchem-2615	214	18	were	be	AUX
eurjchem-2615	214	19	most	most	ADV
eurjchem-2615	214	20	active	active	ADJ
eurjchem-2615	214	21	(	(	PUNCT
eurjchem-2615	214	22	mic	mic	ADJ
eurjchem-2615	214	23	27	27	NUM
eurjchem-2615	214	24	μg	μg	NOUN
eurjchem-2615	214	25	/	/	SYM
eurjchem-2615	214	26	ml	ml	NOUN
eurjchem-2615	214	27	)	)	PUNCT
eurjchem-2615	214	28	and	and	CCONJ
eurjchem-2615	214	29	showed	show	VERB
eurjchem-2615	214	30	no	no	DET
eurjchem-2615	214	31	toxicity	toxicity	NOUN
eurjchem-2615	214	32	to	to	ADP
eurjchem-2615	214	33	hela	hela	VERB
eurjchem-2615	214	34	cells	cell	NOUN
eurjchem-2615	214	35	at	at	ADP
eurjchem-2615	214	36	100	100	NUM
eurjchem-2615	214	37	μg	μg	NOUN
eurjchem-2615	214	38	/	/	SYM
eurjchem-2615	214	39	ml	ml	PROPN
eurjchem-2615	215	1	[	[	X
eurjchem-2615	215	2	82	82	NUM
eurjchem-2615	215	3	]	]	PUNCT
eurjchem-2615	215	4	.	.	PUNCT
eurjchem-2615	216	1	4.7	4.7	NUM
eurjchem-2615	216	2	.	.	PUNCT
eurjchem-2615	217	1	1,2,3	1,2,3	NUM
eurjchem-2615	217	2	-	-	ADJ
eurjchem-2615	217	3	triazole	triazole	NOUN
eurjchem-2615	217	4	-	-	PUNCT
eurjchem-2615	217	5	isatin	isatin	NOUN
eurjchem-2615	217	6	hybrids	hybrid	NOUN
eurjchem-2615	217	7	1h	1h	NUM
eurjchem-2615	217	8	-	-	PUNCT
eurjchem-2615	217	9	indole-2,3	indole-2,3	NOUN
eurjchem-2615	217	10	-	-	PUNCT
eurjchem-2615	217	11	dione	dione	NOUN
eurjchem-2615	217	12	(	(	PUNCT
eurjchem-2615	217	13	isatin	isatin	PROPN
eurjchem-2615	217	14	)	)	PUNCT
eurjchem-2615	217	15	represents	represent	VERB
eurjchem-2615	217	16	a	a	DET
eurjchem-2615	217	17	privileged	privileged	ADJ
eurjchem-2615	217	18	scaffold	scaffold	NOUN
eurjchem-2615	217	19	,	,	PUNCT
eurjchem-2615	217	20	and	and	CCONJ
eurjchem-2615	217	21	its	its	PRON
eurjchem-2615	217	22	hybrids	hybrid	NOUN
eurjchem-2615	217	23	with	with	ADP
eurjchem-2615	217	24	1,2,3	1,2,3	NOUN
eurjchem-2615	217	25	-	-	PUNCT
eurjchem-2615	217	26	triazoles	triazole	NOUN
eurjchem-2615	217	27	have	have	AUX
eurjchem-2615	217	28	shown	show	VERB
eurjchem-2615	217	29	promise	promise	NOUN
eurjchem-2615	217	30	as	as	ADP
eurjchem-2615	217	31	new	new	ADJ
eurjchem-2615	217	32	antitubercular	antitubercular	ADJ
eurjchem-2615	217	33	agents	agent	NOUN
eurjchem-2615	217	34	(	(	PUNCT
eurjchem-2615	217	35	figure	figure	NOUN
eurjchem-2615	217	36	10	10	NUM
eurjchem-2615	217	37	)	)	PUNCT
eurjchem-2615	217	38	.	.	PUNCT
eurjchem-2615	218	1	isatin	isatin	PROPN
eurjchem-2615	218	2	-	-	PUNCT
eurjchem-2615	218	3	oxime	oxime	ADJ
eurjchem-2615	218	4	ether	ether	NOUN
eurjchem-2615	218	5	-	-	PUNCT
eurjchem-2615	218	6	triazole	triazole	NOUN
eurjchem-2615	218	7	hybrids	hybrid	NOUN
eurjchem-2615	218	8	that	that	PRON
eurjchem-2615	218	9	met	meet	VERB
eurjchem-2615	218	10	drug	drug	NOUN
eurjchem-2615	218	11	-	-	PUNCT
eurjchem-2615	218	12	likeness	likeness	NOUN
eurjchem-2615	218	13	criteria	criterion	NOUN
eurjchem-2615	218	14	demonstrated	demonstrate	VERB
eurjchem-2615	218	15	significant	significant	ADJ
eurjchem-2615	218	16	activity	activity	NOUN
eurjchem-2615	218	17	against	against	ADP
eurjchem-2615	218	18	m.	m.	NOUN
eurjchem-2615	218	19	tuberculosis	tuberculosis	NOUN
eurjchem-2615	218	20	h37rv	h37rv	PROPN
eurjchem-2615	218	21	strain	strain	NOUN
eurjchem-2615	218	22	,	,	PUNCT
eurjchem-2615	218	23	with	with	ADP
eurjchem-2615	218	24	compounds	compound	NOUN
eurjchem-2615	218	25	29a	29a	NOUN
eurjchem-2615	218	26	-	-	SYM
eurjchem-2615	218	27	d	d	NOUN
eurjchem-2615	218	28	showing	show	VERB
eurjchem-2615	218	29	promising	promising	ADJ
eurjchem-2615	218	30	mic	mic	ADJ
eurjchem-2615	218	31	values	value	NOUN
eurjchem-2615	218	32	and	and	CCONJ
eurjchem-2615	218	33	good	good	ADJ
eurjchem-2615	218	34	selectivity	selectivity	NOUN
eurjchem-2615	218	35	indices	index	NOUN
eurjchem-2615	218	36	[	[	X
eurjchem-2615	218	37	83	83	NUM
eurjchem-2615	218	38	]	]	PUNCT
eurjchem-2615	218	39	.	.	PUNCT
eurjchem-2615	219	1	hybrids	hybrid	NOUN
eurjchem-2615	219	2	containing	contain	VERB
eurjchem-2615	219	3	an	an	DET
eurjchem-2615	219	4	isoniazid	isoniazid	NOUN
eurjchem-2615	219	5	core	core	NOUN
eurjchem-2615	219	6	showed	show	VERB
eurjchem-2615	219	7	superior	superior	ADJ
eurjchem-2615	219	8	activity	activity	NOUN
eurjchem-2615	219	9	against	against	ADP
eurjchem-2615	219	10	m.	m.	NOUN
eurjchem-2615	219	11	tuberculosis	tuberculosis	NOUN
eurjchem-2615	219	12	mc2	mc2	PROPN
eurjchem-2615	219	13	6230	6230	NUM
eurjchem-2615	219	14	compared	compare	VERB
eurjchem-2615	219	15	to	to	ADP
eurjchem-2615	219	16	those	those	PRON
eurjchem-2615	219	17	with	with	ADP
eurjchem-2615	219	18	semicarbazide	semicarbazide	NOUN
eurjchem-2615	219	19	or	or	CCONJ
eurjchem-2615	219	20	pyrazine-2	pyrazine-2	NUM
eurjchem-2615	219	21	-	-	PUNCT
eurjchem-2615	219	22	carbohydrazide	carbohydrazide	NOUN
eurjchem-2615	219	23	units	unit	NOUN
eurjchem-2615	219	24	,	,	PUNCT
eurjchem-2615	219	25	while	while	SCONJ
eurjchem-2615	219	26	maintaining	maintain	VERB
eurjchem-2615	219	27	low	low	ADJ
eurjchem-2615	219	28	cytotoxicity	cytotoxicity	NOUN
eurjchem-2615	219	29	.	.	PUNCT
eurjchem-2615	220	1	notably	notably	ADV
eurjchem-2615	220	2	,	,	PUNCT
eurjchem-2615	220	3	hybrids	hybrid	NOUN
eurjchem-2615	220	4	30a	30a	NUM
eurjchem-2615	220	5	-	-	SYM
eurjchem-2615	220	6	b	b	NOUN
eurjchem-2615	220	7	,	,	PUNCT
eurjchem-2615	220	8	featuring	feature	VERB
eurjchem-2615	220	9	isoniazid	isoniazid	NOUN
eurjchem-2615	220	10	units	unit	NOUN
eurjchem-2615	220	11	and	and	CCONJ
eurjchem-2615	220	12	electron	electron	NOUN
eurjchem-2615	220	13	-	-	PUNCT
eurjchem-2615	220	14	donating	donate	VERB
eurjchem-2615	220	15	groups	group	NOUN
eurjchem-2615	220	16	at	at	ADP
eurjchem-2615	220	17	isatin	isatin	PROPN
eurjchem-2615	220	18	’s	’s	PART
eurjchem-2615	220	19	c-5	c-5	NOUN
eurjchem-2615	220	20	position	position	NOUN
eurjchem-2615	220	21	,	,	PUNCT
eurjchem-2615	220	22	emerged	emerge	VERB
eurjchem-2615	220	23	as	as	ADP
eurjchem-2615	220	24	the	the	DET
eurjchem-2615	220	25	most	most	ADV
eurjchem-2615	220	26	potent	potent	ADJ
eurjchem-2615	220	27	compounds	compound	NOUN
eurjchem-2615	220	28	,	,	PUNCT
eurjchem-2615	220	29	although	although	SCONJ
eurjchem-2615	220	30	further	further	ADJ
eurjchem-2615	220	31	optimization	optimization	NOUN
eurjchem-2615	220	32	is	be	AUX
eurjchem-2615	220	33	needed	need	VERB
eurjchem-2615	220	34	for	for	ADP
eurjchem-2615	220	35	inh	inh	NOUN
eurjchem-2615	220	36	-	-	PUNCT
eurjchem-2615	220	37	resistant	resistant	ADJ
eurjchem-2615	220	38	strains	strain	NOUN
eurjchem-2615	220	39	[	[	X
eurjchem-2615	220	40	84	84	NUM
eurjchem-2615	220	41	]	]	PUNCT
eurjchem-2615	220	42	.	.	PUNCT
eurjchem-2615	221	1	isatin-1,2,3	isatin-1,2,3	ADJ
eurjchem-2615	221	2	-	-	PUNCT
eurjchem-2615	221	3	triazole	triazole	NOUN
eurjchem-2615	221	4	hybrids	hybrid	NOUN
eurjchem-2615	221	5	31	31	NUM
eurjchem-2615	221	6	showed	show	VERB
eurjchem-2615	221	7	activity	activity	NOUN
eurjchem-2615	221	8	against	against	ADP
eurjchem-2615	221	9	mtb	mtb	NOUN
eurjchem-2615	221	10	h37rv	h37rv	NOUN
eurjchem-2615	221	11	,	,	PUNCT
eurjchem-2615	221	12	with	with	ADP
eurjchem-2615	221	13	activity	activity	NOUN
eurjchem-2615	221	14	influenced	influence	VERB
eurjchem-2615	221	15	by	by	ADP
eurjchem-2615	221	16	phenyl	phenyl	NOUN
eurjchem-2615	221	17	ring	ring	NOUN
eurjchem-2615	221	18	substitution	substitution	NOUN
eurjchem-2615	221	19	patterns	pattern	NOUN
eurjchem-2615	221	20	.	.	PUNCT
eurjchem-2615	222	1	compounds	compound	NOUN
eurjchem-2615	222	2	31a	31a	NUM
eurjchem-2615	222	3	and	and	CCONJ
eurjchem-2615	222	4	31b	31b	NOUN
eurjchem-2615	222	5	(	(	PUNCT
eurjchem-2615	222	6	ic90	ic90	PROPN
eurjchem-2615	222	7	:	:	PUNCT
eurjchem-2615	222	8	7.56	7.56	NUM
eurjchem-2615	222	9	and	and	CCONJ
eurjchem-2615	222	10	8.09	8.09	NUM
eurjchem-2615	222	11	μg	μg	NOUN
eurjchem-2615	222	12	/	/	SYM
eurjchem-2615	222	13	ml	ml	NOUN
eurjchem-2615	222	14	)	)	PUNCT
eurjchem-2615	222	15	were	be	AUX
eurjchem-2615	222	16	most	most	ADV
eurjchem-2615	222	17	active	active	ADJ
eurjchem-2615	222	18	,	,	PUNCT
eurjchem-2615	222	19	although	although	SCONJ
eurjchem-2615	222	20	less	less	ADV
eurjchem-2615	222	21	potent	potent	ADJ
eurjchem-2615	222	22	than	than	ADP
eurjchem-2615	222	23	rifampicin	rifampicin	NOUN
eurjchem-2615	222	24	(	(	PUNCT
eurjchem-2615	222	25	ic90	ic90	PROPN
eurjchem-2615	222	26	:	:	PUNCT
eurjchem-2615	222	27	0.043	0.043	NUM
eurjchem-2615	222	28	μg	μg	NOUN
eurjchem-2615	222	29	/	/	SYM
eurjchem-2615	222	30	ml	ml	NOUN
eurjchem-2615	222	31	)	)	PUNCT
eurjchem-2615	222	32	and	and	CCONJ
eurjchem-2615	222	33	isoniazid	isoniazid	NOUN
eurjchem-2615	222	34	(	(	PUNCT
eurjchem-2615	222	35	ic90	ic90	PROPN
eurjchem-2615	222	36	:	:	PUNCT
eurjchem-2615	222	37	0.075	0.075	NUM
eurjchem-2615	222	38	μg	μg	NOUN
eurjchem-2615	222	39	/	/	SYM
eurjchem-2615	222	40	ml	ml	NOUN
eurjchem-2615	222	41	)	)	PUNCT
eurjchem-2615	223	1	[	[	X
eurjchem-2615	223	2	85	85	NUM
eurjchem-2615	223	3	]	]	PUNCT
eurjchem-2615	223	4	.	.	PUNCT
eurjchem-2615	224	1	1,2,3triazole	1,2,3triazole	NUM
eurjchem-2615	224	2	-	-	PUNCT
eurjchem-2615	224	3	isatin	isatin	ADJ
eurjchem-2615	224	4	32	32	NUM
eurjchem-2615	224	5	,	,	PUNCT
eurjchem-2615	224	6	connected	connect	VERB
eurjchem-2615	224	7	to	to	ADP
eurjchem-2615	224	8	isatin	isatin	PROPN
eurjchem-2615	224	9	through	through	ADP
eurjchem-2615	224	10	tetraethylene	tetraethylene	ADJ
eurjchem-2615	224	11	glycol	glycol	NOUN
eurjchem-2615	224	12	,	,	PUNCT
eurjchem-2615	224	13	showed	show	VERB
eurjchem-2615	224	14	activity	activity	NOUN
eurjchem-2615	224	15	against	against	ADP
eurjchem-2615	224	16	h37rv	h37rv	PROPN
eurjchem-2615	224	17	and	and	CCONJ
eurjchem-2615	224	18	mdr	mdr	PROPN
eurjchem-2615	224	19	-	-	PROPN
eurjchem-2615	224	20	tb	tb	X
eurjchem-2615	224	21	(	(	PUNCT
eurjchem-2615	224	22	mic	mic	ADJ
eurjchem-2615	224	23	:	:	PUNCT
eurjchem-2615	224	24	64512	64512	NUM
eurjchem-2615	224	25	μg	μg	NOUN
eurjchem-2615	224	26	/	/	SYM
eurjchem-2615	224	27	ml	ml	PROPN
eurjchem-2615	224	28	)	)	PUNCT
eurjchem-2615	224	29	.	.	PUNCT
eurjchem-2615	225	1	n-1	n-1	PROPN
eurjchem-2615	225	2	aryl	aryl	NOUN
eurjchem-2615	225	3	substitution	substitution	NOUN
eurjchem-2615	225	4	-	-	PUNCT
eurjchem-2615	225	5	controlled	control	VERB
eurjchem-2615	225	6	lipophilicity	lipophilicity	NOUN
eurjchem-2615	225	7	,	,	PUNCT
eurjchem-2615	225	8	while	while	SCONJ
eurjchem-2615	225	9	c-5	c-5	NOUN
eurjchem-2615	225	10	fluorination	fluorination	NOUN
eurjchem-2615	225	11	enhanced	enhanced	ADJ
eurjchem-2615	225	12	activity	activity	NOUN
eurjchem-2615	225	13	.	.	PUNCT
eurjchem-2615	226	1	the	the	DET
eurjchem-2615	226	2	activity	activity	NOUN
eurjchem-2615	226	3	of	of	ADP
eurjchem-2615	226	4	the	the	DET
eurjchem-2615	226	5	c-3	c-3	NOUN
eurjchem-2615	226	6	substituent	substituent	NOUN
eurjchem-2615	226	7	was	be	AUX
eurjchem-2615	226	8	classified	classify	VERB
eurjchem-2615	226	9	as	as	ADP
eurjchem-2615	226	10	:	:	PUNCT
eurjchem-2615	226	11	-nome	-nome	ADJ
eurjchem-2615	226	12	>	>	X
eurjchem-2615	226	13	-noet	-noet	PROPN
eurjchem-2615	226	14	>	>	X
eurjchem-2615	226	15	-nnhconh2	-nnhconh2	PROPN
eurjchem-2615	226	16	>	>	PUNCT
eurjchem-2615	226	17	–	–	PUNCT
eurjchem-2615	226	18	o	o	X
eurjchem-2615	226	19	>	>	X
eurjchem-2615	226	20	–	–	PUNCT
eurjchem-2615	226	21	noh	noh	PROPN
eurjchem-2615	226	22	.	.	PROPN
eurjchem-2615	226	23	hybrid	hybrid	NOUN
eurjchem-2615	226	24	30	30	NUM
eurjchem-2615	226	25	(	(	PUNCT
eurjchem-2615	226	26	mic	mic	NOUN
eurjchem-2615	226	27	:	:	PUNCT
eurjchem-2615	226	28	128	128	NUM
eurjchem-2615	226	29	μg	μg	NOUN
eurjchem-2615	226	30	/	/	SYM
eurjchem-2615	226	31	ml	ml	NOUN
eurjchem-2615	226	32	h37rv	h37rv	NOUN
eurjchem-2615	226	33	,	,	PUNCT
eurjchem-2615	226	34	64	64	NUM
eurjchem-2615	226	35	μg	μg	NOUN
eurjchem-2615	226	36	/	/	SYM
eurjchem-2615	226	37	ml	ml	NOUN
eurjchem-2615	226	38	mdrtb	mdrtb	NOUN
eurjchem-2615	226	39	)	)	PUNCT
eurjchem-2615	226	40	was	be	AUX
eurjchem-2615	226	41	8	8	NUM
eurjchem-2615	226	42	times	time	NOUN
eurjchem-2615	226	43	more	more	ADV
eurjchem-2615	226	44	potent	potent	ADJ
eurjchem-2615	226	45	than	than	ADP
eurjchem-2615	226	46	isoniazid	isoniazid	NOUN
eurjchem-2615	226	47	against	against	ADP
eurjchem-2615	226	48	mdr	mdr	PROPN
eurjchem-2615	226	49	-	-	PROPN
eurjchem-2615	226	50	tb	tb	PROPN
eurjchem-2615	227	1	[	[	X
eurjchem-2615	227	2	86	86	NUM
eurjchem-2615	227	3	]	]	PUNCT
eurjchem-2615	227	4	.	.	PUNCT
eurjchem-2615	228	1	4.8	4.8	NUM
eurjchem-2615	228	2	.	.	PUNCT
eurjchem-2615	229	1	1,2,3	1,2,3	NUM
eurjchem-2615	229	2	-	-	ADJ
eurjchem-2615	229	3	triazole	triazole	ADJ
eurjchem-2615	229	4	-	-	PUNCT
eurjchem-2615	229	5	furan	furan	NOUN
eurjchem-2615	229	6	hybrids	hybrid	NOUN
eurjchem-2615	229	7	furans	furan	NOUN
eurjchem-2615	229	8	,	,	PUNCT
eurjchem-2615	229	9	particularly	particularly	ADV
eurjchem-2615	229	10	nitrofurans	nitrofuran	NOUN
eurjchem-2615	229	11	,	,	PUNCT
eurjchem-2615	229	12	represent	represent	VERB
eurjchem-2615	229	13	significant	significant	ADJ
eurjchem-2615	229	14	antimicrobial	antimicrobial	ADJ
eurjchem-2615	229	15	pharmacophores	pharmacophore	NOUN
eurjchem-2615	229	16	due	due	ADP
eurjchem-2615	229	17	to	to	ADP
eurjchem-2615	229	18	their	their	PRON
eurjchem-2615	229	19	activation	activation	NOUN
eurjchem-2615	229	20	by	by	ADP
eurjchem-2615	229	21	nitroreductase	nitroreductase	NOUN
eurjchem-2615	229	22	enzymes	enzyme	NOUN
eurjchem-2615	229	23	in	in	ADP
eurjchem-2615	229	24	microorganisms	microorganism	NOUN
eurjchem-2615	229	25	.	.	PUNCT
eurjchem-2615	230	1	therefore	therefore	ADV
eurjchem-2615	230	2	,	,	PUNCT
eurjchem-2615	230	3	the	the	DET
eurjchem-2615	230	4	combination	combination	NOUN
eurjchem-2615	230	5	of	of	ADP
eurjchem-2615	230	6	nitrofuran	nitrofuran	NOUN
eurjchem-2615	230	7	scaffolds	scaffold	NOUN
eurjchem-2615	230	8	with	with	ADP
eurjchem-2615	230	9	1,2,3	1,2,3	NOUN
eurjchem-2615	230	10	-	-	PUNCT
eurjchem-2615	230	11	triazoles	triazole	NOUN
eurjchem-2615	230	12	could	could	AUX
eurjchem-2615	230	13	yield	yield	VERB
eurjchem-2615	230	14	promising	promise	VERB
eurjchem-2615	230	15	new	new	ADJ
eurjchem-2615	230	16	antitubercular	antitubercular	ADJ
eurjchem-2615	230	17	candidates	candidate	NOUN
eurjchem-2615	230	18	[	[	X
eurjchem-2615	230	19	87	87	NUM
eurjchem-2615	230	20	]	]	PUNCT
eurjchem-2615	230	21	(	(	PUNCT
eurjchem-2615	230	22	figure	figure	NOUN
eurjchem-2615	230	23	11	11	NUM
eurjchem-2615	230	24	)	)	PUNCT
eurjchem-2615	230	25	.	.	PUNCT
eurjchem-2615	231	1	the	the	DET
eurjchem-2615	231	2	furan	furan	PROPN
eurjchem-2615	231	3	/	/	SYM
eurjchem-2615	231	4	nitrofuran-1,2,3	nitrofuran-1,2,3	NOUN
eurjchem-2615	231	5	-	-	PUNCT
eurjchem-2615	231	6	triazole	triazole	NOUN
eurjchem-2615	231	7	hybrids	hybrid	NOUN
eurjchem-2615	231	8	33	33	NUM
eurjchem-2615	231	9	showed	show	VERB
eurjchem-2615	231	10	effective	effective	ADJ
eurjchem-2615	231	11	activity	activity	NOUN
eurjchem-2615	231	12	against	against	ADP
eurjchem-2615	231	13	m.	m.	NOUN
eurjchem-2615	231	14	tuberculosis	tuberculosis	NOUN
eurjchem-2615	231	15	h37rv	h37rv	PROPN
eurjchem-2615	231	16	,	,	PUNCT
eurjchem-2615	231	17	comparable	comparable	ADJ
eurjchem-2615	231	18	to	to	AUX
eurjchem-2615	231	19	ethambutol	ethambutol	VERB
eurjchem-2615	231	20	.	.	PUNCT
eurjchem-2615	232	1	92	92	NUM
eurjchem-2615	232	2	zimo	zimo	ADJ
eurjchem-2615	232	3	and	and	CCONJ
eurjchem-2615	232	4	coghi	coghi	PROPN
eurjchem-2615	232	5	/	/	SYM
eurjchem-2615	232	6	european	european	PROPN
eurjchem-2615	232	7	journal	journal	PROPN
eurjchem-2615	232	8	of	of	ADP
eurjchem-2615	232	9	chemistry	chemistry	NOUN
eurjchem-2615	232	10	16	16	NUM
eurjchem-2615	232	11	(	(	PUNCT
eurjchem-2615	232	12	1	1	NUM
eurjchem-2615	232	13	)	)	PUNCT
eurjchem-2615	232	14	(	(	PUNCT
eurjchem-2615	232	15	2025	2025	NUM
eurjchem-2615	232	16	)	)	PUNCT
eurjchem-2615	232	17	83	83	NUM
eurjchem-2615	232	18	-	-	SYM
eurjchem-2615	232	19	96	96	NUM
eurjchem-2615	232	20	2025	2025	NUM
eurjchem-2615	232	21	–	–	PUNCT
eurjchem-2615	232	22	european	european	ADJ
eurjchem-2615	232	23	journal	journal	NOUN
eurjchem-2615	232	24	of	of	ADP
eurjchem-2615	232	25	chemistry	chemistry	NOUN
eurjchem-2615	232	26	–	–	PUNCT
eurjchem-2615	232	27	cc	cc	NOUN
eurjchem-2615	232	28	by	by	ADP
eurjchem-2615	232	29	nc	nc	PROPN
eurjchem-2615	232	30	–	–	PUNCT
eurjchem-2615	232	31	doi	doi	NOUN
eurjchem-2615	232	32	:	:	PUNCT
eurjchem-2615	232	33	10.5155	10.5155	NUM
eurjchem-2615	232	34	/	/	SYM
eurjchem-2615	232	35	eurjchem.16.1.83	eurjchem.16.1.83	ADJ
eurjchem-2615	232	36	-	-	PUNCT
eurjchem-2615	232	37	96.2615	96.2615	NUM
eurjchem-2615	232	38	o	o	NOUN
eurjchem-2615	232	39	r1	r1	PROPN
eurjchem-2615	232	40	n	n	PROPN
eurjchem-2615	232	41	nh	nh	NOUN
eurjchem-2615	232	42	o	o	PROPN
eurjchem-2615	232	43	n	n	CCONJ
eurjchem-2615	232	44	n	n	PROPN
eurjchem-2615	232	45	n	n	ADV
eurjchem-2615	232	46	me	i	PRON
eurjchem-2615	232	47	nh	nh	PROPN
eurjchem-2615	232	48	r2	r2	PROPN
eurjchem-2615	232	49	33	33	NUM
eurjchem-2615	232	50	r1	r1	PROPN
eurjchem-2615	232	51	=	=	PROPN
eurjchem-2615	232	52	h;no2;br	h;no2;br	ADJ
eurjchem-2615	232	53	r2	r2	NOUN
eurjchem-2615	232	54	=	=	PROPN
eurjchem-2615	232	55	h;cl;br;f	h;cl;br;f	NOUN
eurjchem-2615	232	56	o	o	NOUN
eurjchem-2615	232	57	n	n	CCONJ
eurjchem-2615	232	58	nn	nn	INTJ
eurjchem-2615	232	59	r	r	NOUN
eurjchem-2615	232	60	34	34	NUM
eurjchem-2615	232	61	34a	34a	NUM
eurjchem-2615	232	62	:	:	PUNCT
eurjchem-2615	232	63	r=4	r=4	PROPN
eurjchem-2615	232	64	-	-	NOUN
eurjchem-2615	232	65	b	b	NOUN
eurjchem-2615	232	66	34b	34b	NUM
eurjchem-2615	232	67	:	:	PUNCT
eurjchem-2615	232	68	r=3	r=3	PROPN
eurjchem-2615	232	69	-	-	PUNCT
eurjchem-2615	232	70	ome	ome	NOUN
eurjchem-2615	232	71	o	o	NOUN
eurjchem-2615	232	72	ho	ho	X
eurjchem-2615	233	1	o	o	INTJ
eurjchem-2615	234	1	oh	oh	INTJ
eurjchem-2615	234	2	o	o	INTJ
eurjchem-2615	235	1	n	n	PRON
eurjchem-2615	235	2	h	h	NOUN
eurjchem-2615	236	1	o	o	NOUN
eurjchem-2615	236	2	n	n	CCONJ
eurjchem-2615	236	3	n	n	CCONJ
eurjchem-2615	236	4	n	n	CCONJ
eurjchem-2615	236	5	n	n	NOUN
eurjchem-2615	236	6	s	s	PART
eurjchem-2615	236	7	o	o	NOUN
eurjchem-2615	236	8	o	o	X
eurjchem-2615	236	9	o	o	NOUN
eurjchem-2615	236	10	35	35	NUM
eurjchem-2615	236	11	figure	figure	NOUN
eurjchem-2615	236	12	11	11	NUM
eurjchem-2615	236	13	.	.	PUNCT
eurjchem-2615	237	1	chemical	chemical	NOUN
eurjchem-2615	237	2	structures	structure	NOUN
eurjchem-2615	237	3	of	of	ADP
eurjchem-2615	237	4	1,2,3	1,2,3	NUM
eurjchem-2615	237	5	-	-	ADJ
eurjchem-2615	237	6	triazole	triazole	ADJ
eurjchem-2615	237	7	-	-	PUNCT
eurjchem-2615	237	8	furan	furan	NOUN
eurjchem-2615	237	9	hybrids	hybrid	NOUN
eurjchem-2615	237	10	33	33	NUM
eurjchem-2615	237	11	-	-	SYM
eurjchem-2615	237	12	35	35	NUM
eurjchem-2615	237	13	.	.	PUNCT
eurjchem-2615	238	1	sar	sar	PROPN
eurjchem-2615	238	2	studies	studies	PROPN
eurjchem-2615	238	3	demonstrated	demonstrate	VERB
eurjchem-2615	238	4	that	that	SCONJ
eurjchem-2615	238	5	nitrofuran	nitrofuran	NOUN
eurjchem-2615	238	6	variants	variant	NOUN
eurjchem-2615	238	7	were	be	AUX
eurjchem-2615	238	8	more	more	ADV
eurjchem-2615	238	9	potent	potent	ADJ
eurjchem-2615	238	10	than	than	ADP
eurjchem-2615	238	11	furan	furan	PROPN
eurjchem-2615	238	12	hybrids	hybrid	NOUN
eurjchem-2615	238	13	,	,	PUNCT
eurjchem-2615	238	14	with	with	ADP
eurjchem-2615	238	15	increased	increase	VERB
eurjchem-2615	238	16	activity	activity	NOUN
eurjchem-2615	238	17	observed	observe	VERB
eurjchem-2615	238	18	in	in	ADP
eurjchem-2615	238	19	compounds	compound	NOUN
eurjchem-2615	238	20	with	with	ADP
eurjchem-2615	238	21	lower	low	ADJ
eurjchem-2615	238	22	lipophilicity	lipophilicity	NOUN
eurjchem-2615	238	23	and	and	CCONJ
eurjchem-2615	238	24	smaller	small	ADJ
eurjchem-2615	238	25	r1	r1	NOUN
eurjchem-2615	238	26	substituents	substituent	NOUN
eurjchem-2615	238	27	[	[	X
eurjchem-2615	238	28	88	88	NUM
eurjchem-2615	238	29	]	]	PUNCT
eurjchem-2615	238	30	.	.	PUNCT
eurjchem-2615	239	1	hybrids	hybrid	NOUN
eurjchem-2615	239	2	34a	34a	PROPN
eurjchem-2615	239	3	,	,	PUNCT
eurjchem-2615	239	4	b	b	NUM
eurjchem-2615	239	5	emerged	emerge	VERB
eurjchem-2615	239	6	as	as	ADP
eurjchem-2615	239	7	the	the	DET
eurjchem-2615	239	8	most	most	ADV
eurjchem-2615	239	9	effective	effective	ADJ
eurjchem-2615	239	10	compounds	compound	NOUN
eurjchem-2615	239	11	in	in	ADP
eurjchem-2615	239	12	the	the	DET
eurjchem-2615	239	13	series	series	NOUN
eurjchem-2615	239	14	,	,	PUNCT
eurjchem-2615	239	15	demonstrating	demonstrate	VERB
eurjchem-2615	239	16	high	high	ADJ
eurjchem-2615	239	17	potency	potency	NOUN
eurjchem-2615	239	18	and	and	CCONJ
eurjchem-2615	239	19	low	low	ADJ
eurjchem-2615	239	20	cytotoxicity	cytotoxicity	NOUN
eurjchem-2615	239	21	[	[	X
eurjchem-2615	239	22	89	89	NUM
eurjchem-2615	239	23	]	]	PUNCT
eurjchem-2615	239	24	.	.	PUNCT
eurjchem-2615	240	1	the	the	DET
eurjchem-2615	240	2	sar	sar	NOUN
eurjchem-2615	240	3	analysis	analysis	NOUN
eurjchem-2615	240	4	of	of	ADP
eurjchem-2615	240	5	hybrid	hybrid	ADJ
eurjchem-2615	240	6	32	32	NUM
eurjchem-2615	240	7	showed	show	VERB
eurjchem-2615	240	8	that	that	SCONJ
eurjchem-2615	240	9	the	the	DET
eurjchem-2615	240	10	electron	electron	NOUN
eurjchem-2615	240	11	-	-	PUNCT
eurjchem-2615	240	12	donating	donate	VERB
eurjchem-2615	240	13	groups	group	NOUN
eurjchem-2615	240	14	(	(	PUNCT
eurjchem-2615	240	15	like	like	ADP
eurjchem-2615	240	16	-ome	-ome	ADV
eurjchem-2615	240	17	)	)	PUNCT
eurjchem-2615	240	18	provided	provide	VERB
eurjchem-2615	240	19	better	well	ADJ
eurjchem-2615	240	20	activity	activity	NOUN
eurjchem-2615	240	21	compared	compare	VERB
eurjchem-2615	240	22	to	to	ADP
eurjchem-2615	240	23	the	the	DET
eurjchem-2615	240	24	electron	electron	NOUN
eurjchem-2615	240	25	-	-	PUNCT
eurjchem-2615	240	26	withdrawing	withdraw	VERB
eurjchem-2615	240	27	groups	group	NOUN
eurjchem-2615	240	28	(	(	PUNCT
eurjchem-2615	240	29	such	such	ADJ
eurjchem-2615	240	30	as	as	ADP
eurjchem-2615	240	31	-no2	-no2	PROPN
eurjchem-2615	240	32	,	,	PUNCT
eurjchem-2615	240	33	coome	coome	NOUN
eurjchem-2615	240	34	)	)	PUNCT
eurjchem-2615	240	35	.	.	PUNCT
eurjchem-2615	241	1	(	(	PUNCT
eurjchem-2615	241	2	+	+	ADJ
eurjchem-2615	241	3	)	)	PUNCT
eurjchem-2615	241	4	ustic	ustic	ADJ
eurjchem-2615	241	5	acid	acid	NOUN
eurjchem-2615	241	6	,	,	PUNCT
eurjchem-2615	241	7	a	a	DET
eurjchem-2615	241	8	lichen	lichen	NOUN
eurjchem-2615	241	9	metabolite	metabolite	NOUN
eurjchem-2615	241	10	,	,	PUNCT
eurjchem-2615	241	11	shows	show	VERB
eurjchem-2615	241	12	anti	anti	ADJ
eurjchem-2615	241	13	-	-	ADJ
eurjchem-2615	241	14	tb	tb	ADP
eurjchem-2615	241	15	activity	activity	NOUN
eurjchem-2615	241	16	.	.	PUNCT
eurjchem-2615	242	1	ustic	ustic	ADJ
eurjchem-2615	242	2	acid	acid	NOUN
eurjchem-2615	242	3	35	35	NUM
eurjchem-2615	242	4	(	(	PUNCT
eurjchem-2615	242	5	mic	mic	NOUN
eurjchem-2615	242	6	:	:	PUNCT
eurjchem-2615	242	7	2.5	2.5	NUM
eurjchem-2615	242	8	μm	μm	NOUN
eurjchem-2615	242	9	)	)	PUNCT
eurjchem-2615	242	10	demonstrated	demonstrate	VERB
eurjchem-2615	242	11	enhanced	enhanced	ADJ
eurjchem-2615	242	12	potency	potency	NOUN
eurjchem-2615	242	13	through	through	ADP
eurjchem-2615	242	14	the	the	DET
eurjchem-2615	242	15	substitution	substitution	NOUN
eurjchem-2615	242	16	of	of	ADP
eurjchem-2615	242	17	fluorine	fluorine	NOUN
eurjchem-2615	242	18	and	and	CCONJ
eurjchem-2615	242	19	the	the	DET
eurjchem-2615	242	20	incorporation	incorporation	NOUN
eurjchem-2615	242	21	of	of	ADP
eurjchem-2615	242	22	cyclic	cyclic	ADJ
eurjchem-2615	242	23	sulfonamide	sulfonamide	NOUN
eurjchem-2615	242	24	in	in	ADP
eurjchem-2615	242	25	the	the	DET
eurjchem-2615	242	26	usnic	usnic	ADJ
eurjchem-2615	242	27	acid	acid	NOUN
eurjchem-2615	242	28	scaffold	scaffold	NOUN
eurjchem-2615	242	29	,	,	PUNCT
eurjchem-2615	242	30	suggesting	suggest	VERB
eurjchem-2615	242	31	potential	potential	ADJ
eurjchem-2615	242	32	as	as	ADP
eurjchem-2615	242	33	a	a	DET
eurjchem-2615	242	34	lead	lead	NOUN
eurjchem-2615	242	35	compound	compound	NOUN
eurjchem-2615	243	1	[	[	X
eurjchem-2615	243	2	82	82	NUM
eurjchem-2615	243	3	]	]	PUNCT
eurjchem-2615	243	4	.	.	PUNCT
eurjchem-2615	244	1	4.9	4.9	NUM
eurjchem-2615	244	2	.	.	PUNCT
eurjchem-2615	245	1	miscellaneous	miscellaneous	ADJ
eurjchem-2615	245	2	1,2,3	1,2,3	NUM
eurjchem-2615	245	3	-	-	PUNCT
eurjchem-2615	245	4	triazoles	triazole	NOUN
eurjchem-2615	245	5	triclosan	triclosan	NOUN
eurjchem-2615	245	6	functions	function	NOUN
eurjchem-2615	245	7	as	as	ADP
eurjchem-2615	245	8	an	an	DET
eurjchem-2615	245	9	antibacterial	antibacterial	ADJ
eurjchem-2615	245	10	and	and	CCONJ
eurjchem-2615	245	11	antifungal	antifungal	ADJ
eurjchem-2615	245	12	agent	agent	NOUN
eurjchem-2615	245	13	commonly	commonly	ADV
eurjchem-2615	245	14	found	find	VERB
eurjchem-2615	245	15	in	in	ADP
eurjchem-2615	245	16	various	various	ADJ
eurjchem-2615	245	17	consumer	consumer	NOUN
eurjchem-2615	245	18	and	and	CCONJ
eurjchem-2615	245	19	medical	medical	ADJ
eurjchem-2615	245	20	products	product	NOUN
eurjchem-2615	245	21	.	.	PUNCT
eurjchem-2615	246	1	as	as	ADP
eurjchem-2615	246	2	an	an	DET
eurjchem-2615	246	3	antitubercular	antitubercular	ADJ
eurjchem-2615	246	4	compound	compound	NOUN
eurjchem-2615	246	5	,	,	PUNCT
eurjchem-2615	246	6	it	it	PRON
eurjchem-2615	246	7	directly	directly	ADV
eurjchem-2615	246	8	inhibits	inhibit	VERB
eurjchem-2615	246	9	the	the	DET
eurjchem-2615	246	10	inha	inha	NOUN
eurjchem-2615	246	11	enzyme	enzyme	NOUN
eurjchem-2615	246	12	without	without	ADP
eurjchem-2615	246	13	requiring	require	VERB
eurjchem-2615	246	14	katg	katg	NOUN
eurjchem-2615	246	15	activation	activation	NOUN
eurjchem-2615	246	16	,	,	PUNCT
eurjchem-2615	246	17	distinguishing	distinguish	VERB
eurjchem-2615	246	18	it	it	PRON
eurjchem-2615	246	19	from	from	ADP
eurjchem-2615	246	20	some	some	DET
eurjchem-2615	246	21	other	other	ADJ
eurjchem-2615	246	22	tb	tb	ADP
eurjchem-2615	246	23	drugs	drug	NOUN
eurjchem-2615	246	24	[	[	X
eurjchem-2615	246	25	90	90	NUM
eurjchem-2615	246	26	]	]	PUNCT
eurjchem-2615	246	27	.	.	PUNCT
eurjchem-2615	247	1	poor	poor	ADJ
eurjchem-2615	247	2	bioavailability	bioavailability	NOUN
eurjchem-2615	247	3	limits	limit	VERB
eurjchem-2615	247	4	the	the	DET
eurjchem-2615	247	5	use	use	NOUN
eurjchem-2615	247	6	of	of	ADP
eurjchem-2615	247	7	triclosan	triclosan	NOUN
eurjchem-2615	247	8	as	as	ADP
eurjchem-2615	247	9	an	an	DET
eurjchem-2615	247	10	antitubercular	antitubercular	ADJ
eurjchem-2615	247	11	agent	agent	NOUN
eurjchem-2615	247	12	.	.	PUNCT
eurjchem-2615	248	1	molecular	molecular	ADJ
eurjchem-2615	248	2	hybriddization	hybriddization	NOUN
eurjchem-2615	248	3	with	with	ADP
eurjchem-2615	248	4	pharmacophores	pharmacophore	NOUN
eurjchem-2615	248	5	such	such	ADJ
eurjchem-2615	248	6	as	as	ADP
eurjchem-2615	248	7	1,2,3	1,2,3	NOUN
eurjchem-2615	248	8	-	-	NOUN
eurjchem-2615	248	9	triazoles	triazole	NOUN
eurjchem-2615	248	10	can	can	AUX
eurjchem-2615	248	11	enhance	enhance	VERB
eurjchem-2615	248	12	its	its	PRON
eurjchem-2615	248	13	biological	biological	ADJ
eurjchem-2615	248	14	activity	activity	NOUN
eurjchem-2615	248	15	.	.	PUNCT
eurjchem-2615	249	1	researchers	researcher	NOUN
eurjchem-2615	249	2	have	have	AUX
eurjchem-2615	249	3	explored	explore	VERB
eurjchem-2615	249	4	various	various	ADJ
eurjchem-2615	249	5	modifications	modification	NOUN
eurjchem-2615	249	6	of	of	ADP
eurjchem-2615	249	7	these	these	DET
eurjchem-2615	249	8	hybrids	hybrid	NOUN
eurjchem-2615	249	9	to	to	PART
eurjchem-2615	249	10	study	study	VERB
eurjchem-2615	249	11	how	how	SCONJ
eurjchem-2615	249	12	substituent	substituent	NOUN
eurjchem-2615	249	13	properties	property	NOUN
eurjchem-2615	249	14	,	,	PUNCT
eurjchem-2615	249	15	phenyl	phenyl	NOUN
eurjchem-2615	249	16	groups	group	NOUN
eurjchem-2615	249	17	,	,	PUNCT
eurjchem-2615	249	18	alkyl	alkyl	NOUN
eurjchem-2615	249	19	chain	chain	NOUN
eurjchem-2615	249	20	length	length	NOUN
eurjchem-2615	249	21	,	,	PUNCT
eurjchem-2615	249	22	and	and	CCONJ
eurjchem-2615	249	23	triazole	triazole	NOUN
eurjchem-2615	249	24	link	link	NOUN
eurjchem-2615	249	25	positions	position	NOUN
eurjchem-2615	249	26	affect	affect	VERB
eurjchem-2615	249	27	their	their	PRON
eurjchem-2615	249	28	efficacy	efficacy	NOUN
eurjchem-2615	249	29	[	[	X
eurjchem-2615	249	30	91	91	NUM
eurjchem-2615	249	31	]	]	PUNCT
eurjchem-2615	249	32	(	(	PUNCT
eurjchem-2615	249	33	figure	figure	NOUN
eurjchem-2615	249	34	12	12	NUM
eurjchem-2615	249	35	)	)	PUNCT
eurjchem-2615	249	36	.	.	PUNCT
eurjchem-2615	250	1	the	the	DET
eurjchem-2615	250	2	sar	sar	PROPN
eurjchem-2615	250	3	analysis	analysis	NOUN
eurjchem-2615	250	4	revealed	reveal	VERB
eurjchem-2615	250	5	that	that	SCONJ
eurjchem-2615	250	6	the	the	DET
eurjchem-2615	250	7	methylenic	methylenic	ADJ
eurjchem-2615	250	8	links	link	NOUN
eurjchem-2615	250	9	between	between	ADP
eurjchem-2615	250	10	the	the	DET
eurjchem-2615	250	11	triazole	triazole	ADJ
eurjchem-2615	250	12	and	and	CCONJ
eurjchem-2615	250	13	aromatic	aromatic	ADJ
eurjchem-2615	250	14	frameworks	framework	NOUN
eurjchem-2615	250	15	reduced	reduce	VERB
eurjchem-2615	250	16	the	the	DET
eurjchem-2615	250	17	activity	activity	NOUN
eurjchem-2615	250	18	.	.	PUNCT
eurjchem-2615	251	1	on	on	ADP
eurjchem-2615	251	2	the	the	DET
eurjchem-2615	251	3	contrary	contrary	NOUN
eurjchem-2615	251	4	,	,	PUNCT
eurjchem-2615	251	5	increasing	increase	VERB
eurjchem-2615	251	6	the	the	DET
eurjchem-2615	251	7	length	length	NOUN
eurjchem-2615	251	8	of	of	ADP
eurjchem-2615	251	9	the	the	DET
eurjchem-2615	251	10	alkyl	alkyl	NOUN
eurjchem-2615	251	11	chain	chain	NOUN
eurjchem-2615	251	12	increased	increase	VERB
eurjchem-2615	251	13	the	the	DET
eurjchem-2615	251	14	potency	potency	NOUN
eurjchem-2615	251	15	,	,	PUNCT
eurjchem-2615	251	16	with	with	ADP
eurjchem-2615	251	17	optimal	optimal	ADJ
eurjchem-2615	251	18	activity	activity	NOUN
eurjchem-2615	251	19	observed	observe	VERB
eurjchem-2615	251	20	in	in	ADP
eurjchem-2615	251	21	compounds	compound	NOUN
eurjchem-2615	251	22	containing	contain	VERB
eurjchem-2615	251	23	a	a	DET
eurjchem-2615	251	24	12	12	NUM
eurjchem-2615	251	25	-	-	PUNCT
eurjchem-2615	251	26	carbon	carbon	NOUN
eurjchem-2615	251	27	chain	chain	NOUN
eurjchem-2615	251	28	(	(	PUNCT
eurjchem-2615	251	29	36	36	NUM
eurjchem-2615	251	30	,	,	PUNCT
eurjchem-2615	251	31	mic	mic	ADJ
eurjchem-2615	251	32	:	:	PUNCT
eurjchem-2615	251	33	0.25	0.25	NUM
eurjchem-2615	251	34	μg	μg	PROPN
eurjchem-2615	251	35	/	/	SYM
eurjchem-2615	251	36	ml	ml	NOUN
eurjchem-2615	251	37	)	)	PUNCT
eurjchem-2615	252	1	[	[	X
eurjchem-2615	252	2	92	92	NUM
eurjchem-2615	252	3	]	]	PUNCT
eurjchem-2615	252	4	.	.	PUNCT
eurjchem-2615	253	1	1,2,3	1,2,3	NUM
eurjchem-2615	253	2	-	-	NOUN
eurjchem-2615	253	3	triazoles	triazole	NOUN
eurjchem-2615	253	4	combined	combine	VERB
eurjchem-2615	253	5	with	with	ADP
eurjchem-2615	253	6	tricyclic	tricyclic	ADJ
eurjchem-2615	253	7	frameworks	framework	NOUN
eurjchem-2615	253	8	showed	show	VERB
eurjchem-2615	253	9	promising	promise	VERB
eurjchem-2615	253	10	anti	anti	ADJ
eurjchem-2615	253	11	-	-	ADJ
eurjchem-2615	253	12	tb	tb	ADP
eurjchem-2615	253	13	activity	activity	NOUN
eurjchem-2615	253	14	,	,	PUNCT
eurjchem-2615	253	15	with	with	ADP
eurjchem-2615	253	16	potency	potency	NOUN
eurjchem-2615	253	17	following	follow	VERB
eurjchem-2615	253	18	the	the	DET
eurjchem-2615	253	19	order	order	NOUN
eurjchem-2615	253	20	:	:	PUNCT
eurjchem-2615	253	21	dibenzo[b	dibenzo[b	ADJ
eurjchem-2615	253	22	,	,	PUNCT
eurjchem-2615	253	23	d]thiophene	d]thiophene	PROPN
eurjchem-2615	253	24	>	>	X
eurjchem-2615	253	25	dibenzo[b	dibenzo[b	PROPN
eurjchem-2615	253	26	,	,	PUNCT
eurjchem-2615	253	27	d	d	X
eurjchem-2615	253	28	]	]	X
eurjchem-2615	253	29	furan	furan	PROPN
eurjchem-2615	253	30	>	>	X
eurjchem-2615	253	31	9	9	NUM
eurjchem-2615	253	32	-	-	PUNCT
eurjchem-2615	253	33	methyl-9h	methyl-9h	NOUN
eurjchem-2615	253	34	-	-	PUNCT
eurjchem-2615	253	35	carbazole	carbazole	NOUN
eurjchem-2615	253	36	.	.	PUNCT
eurjchem-2615	254	1	hybrids	hybrid	NOUN
eurjchem-2615	254	2	37a	37a	NOUN
eurjchem-2615	254	3	-	-	SYM
eurjchem-2615	254	4	b	b	NOUN
eurjchem-2615	254	5	demonstrated	demonstrate	VERB
eurjchem-2615	254	6	high	high	ADJ
eurjchem-2615	254	7	potency	potency	NOUN
eurjchem-2615	254	8	with	with	ADP
eurjchem-2615	254	9	minimal	minimal	ADJ
eurjchem-2615	254	10	cytotoxicity	cytotoxicity	NOUN
eurjchem-2615	254	11	against	against	ADP
eurjchem-2615	254	12	multiple	multiple	ADJ
eurjchem-2615	254	13	cell	cell	NOUN
eurjchem-2615	254	14	lines	line	NOUN
eurjchem-2615	254	15	,	,	PUNCT
eurjchem-2615	254	16	showing	show	VERB
eurjchem-2615	254	17	superior	superior	ADJ
eurjchem-2615	254	18	activity	activity	NOUN
eurjchem-2615	254	19	compared	compare	VERB
eurjchem-2615	254	20	to	to	PART
eurjchem-2615	254	21	pyrazinamide	pyrazinamide	VERB
eurjchem-2615	254	22	and	and	CCONJ
eurjchem-2615	254	23	ethambutol	ethambutol	X
eurjchem-2615	255	1	[	[	X
eurjchem-2615	255	2	93,94	93,94	NUM
eurjchem-2615	255	3	]	]	PUNCT
eurjchem-2615	255	4	.	.	PUNCT
eurjchem-2615	256	1	phenanthridine	phenanthridine	NOUN
eurjchem-2615	256	2	-	-	PUNCT
eurjchem-2615	256	3	triazole	triazole	NOUN
eurjchem-2615	256	4	hybrids	hybrid	NOUN
eurjchem-2615	256	5	38	38	NUM
eurjchem-2615	256	6	showed	show	VERB
eurjchem-2615	256	7	notable	notable	ADJ
eurjchem-2615	256	8	activity	activity	NOUN
eurjchem-2615	256	9	against	against	ADP
eurjchem-2615	256	10	m.	m.	NOUN
eurjchem-2615	256	11	tuberculosis	tuberculosis	NOUN
eurjchem-2615	256	12	h37rv	h37rv	PROPN
eurjchem-2615	256	13	.	.	PUNCT
eurjchem-2615	257	1	sar	sar	PROPN
eurjchem-2615	257	2	studies	studies	PROPN
eurjchem-2615	257	3	revealed	reveal	VERB
eurjchem-2615	257	4	that	that	SCONJ
eurjchem-2615	257	5	para	para	NOUN
eurjchem-2615	257	6	-	-	PUNCT
eurjchem-2615	257	7	ome	ome	NOUN
eurjchem-2615	257	8	substituents	substituent	NOUN
eurjchem-2615	257	9	enhanced	enhance	VERB
eurjchem-2615	257	10	activity	activity	NOUN
eurjchem-2615	257	11	15	15	NUM
eurjchem-2615	257	12	times	time	NOUN
eurjchem-2615	257	13	compared	compare	VERB
eurjchem-2615	257	14	to	to	ADP
eurjchem-2615	257	15	meta	meta	ADJ
eurjchem-2615	257	16	-	-	PUNCT
eurjchem-2615	257	17	substitution	substitution	NOUN
eurjchem-2615	257	18	.	.	PUNCT
eurjchem-2615	258	1	the	the	DET
eurjchem-2615	258	2	introduction	introduction	NOUN
eurjchem-2615	258	3	of	of	ADP
eurjchem-2615	258	4	a	a	DET
eurjchem-2615	258	5	sulfonyl	sulfonyl	NOUN
eurjchem-2615	258	6	group	group	NOUN
eurjchem-2615	258	7	between	between	ADP
eurjchem-2615	258	8	triazole	triazole	NOUN
eurjchem-2615	258	9	and	and	CCONJ
eurjchem-2615	258	10	phenyl	phenyl	NOUN
eurjchem-2615	258	11	rings	ring	NOUN
eurjchem-2615	258	12	significantly	significantly	ADV
eurjchem-2615	258	13	improved	improve	VERB
eurjchem-2615	258	14	activity	activity	NOUN
eurjchem-2615	258	15	,	,	PUNCT
eurjchem-2615	258	16	likely	likely	ADJ
eurjchem-2615	258	17	because	because	SCONJ
eurjchem-2615	258	18	of	of	ADP
eurjchem-2615	258	19	hydrogen	hydrogen	NOUN
eurjchem-2615	258	20	bond	bond	NOUN
eurjchem-2615	258	21	acceptability	acceptability	NOUN
eurjchem-2615	258	22	.	.	PUNCT
eurjchem-2615	259	1	compound	compound	NOUN
eurjchem-2615	259	2	38a	38a	PROPN
eurjchem-2615	259	3	demonstrated	demonstrate	VERB
eurjchem-2615	259	4	superior	superior	ADJ
eurjchem-2615	259	5	potency	potency	NOUN
eurjchem-2615	259	6	compared	compare	VERB
eurjchem-2615	259	7	to	to	ADP
eurjchem-2615	259	8	hybrids	hybrid	NOUN
eurjchem-2615	259	9	38b	38b	NOUN
eurjchem-2615	259	10	,	,	PUNCT
eurjchem-2615	259	11	c	c	PROPN
eurjchem-2615	260	1	[	[	X
eurjchem-2615	260	2	95	95	NUM
eurjchem-2615	260	3	]	]	PUNCT
eurjchem-2615	260	4	.	.	PUNCT
eurjchem-2615	261	1	linezolid	linezolid	PROPN
eurjchem-2615	261	2	,	,	PUNCT
eurjchem-2615	261	3	an	an	DET
eurjchem-2615	261	4	oxazolidinone	oxazolidinone	NUM
eurjchem-2615	261	5	-	-	PUNCT
eurjchem-2615	261	6	class	class	NOUN
eurjchem-2615	261	7	antibiotic	antibiotic	NOUN
eurjchem-2615	261	8	with	with	ADP
eurjchem-2615	261	9	a	a	DET
eurjchem-2615	261	10	mic	mic	NOUN
eurjchem-2615	261	11	of	of	ADP
eurjchem-2615	261	12	1.0	1.0	NUM
eurjchem-2615	261	13	μg	μg	NOUN
eurjchem-2615	261	14	/	/	SYM
eurjchem-2615	261	15	ml	ml	PROPN
eurjchem-2615	261	16	,	,	PUNCT
eurjchem-2615	261	17	is	be	AUX
eurjchem-2615	261	18	recognized	recognize	VERB
eurjchem-2615	261	19	for	for	ADP
eurjchem-2615	261	20	its	its	PRON
eurjchem-2615	261	21	role	role	NOUN
eurjchem-2615	261	22	in	in	ADP
eurjchem-2615	261	23	inhibiting	inhibit	VERB
eurjchem-2615	261	24	protein	protein	NOUN
eurjchem-2615	261	25	synthesis	synthesis	NOUN
eurjchem-2615	261	26	and	and	CCONJ
eurjchem-2615	261	27	has	have	AUX
eurjchem-2615	261	28	been	be	AUX
eurjchem-2615	261	29	endorsed	endorse	VERB
eurjchem-2615	261	30	by	by	ADP
eurjchem-2615	261	31	the	the	DET
eurjchem-2615	261	32	who	who	PRON
eurjchem-2615	261	33	for	for	ADP
eurjchem-2615	261	34	the	the	DET
eurjchem-2615	261	35	treatment	treatment	NOUN
eurjchem-2615	261	36	of	of	ADP
eurjchem-2615	261	37	multidrug	multidrug	NOUN
eurjchem-2615	261	38	-	-	PUNCT
eurjchem-2615	261	39	resistant	resistant	ADJ
eurjchem-2615	261	40	(	(	PUNCT
eurjchem-2615	261	41	mdr	mdr	NOUN
eurjchem-2615	261	42	)	)	PUNCT
eurjchem-2615	261	43	and	and	CCONJ
eurjchem-2615	261	44	extensively	extensively	ADV
eurjchem-2615	261	45	drug	drug	NOUN
eurjchem-2615	261	46	-	-	PUNCT
eurjchem-2615	261	47	resistant	resistant	ADJ
eurjchem-2615	261	48	(	(	PUNCT
eurjchem-2615	261	49	xdr	xdr	PROPN
eurjchem-2615	261	50	)	)	PUNCT
eurjchem-2615	262	1	tuberculosis	tuberculosis	NOUN
eurjchem-2615	263	1	[	[	X
eurjchem-2615	263	2	96	96	NUM
eurjchem-2615	263	3	]	]	PUNCT
eurjchem-2615	263	4	.	.	PUNCT
eurjchem-2615	264	1	however	however	ADV
eurjchem-2615	264	2	,	,	PUNCT
eurjchem-2615	264	3	the	the	DET
eurjchem-2615	264	4	prolonged	prolonged	ADJ
eurjchem-2615	264	5	use	use	NOUN
eurjchem-2615	264	6	of	of	ADP
eurjchem-2615	264	7	oxazolidinones	oxazolidinone	NOUN
eurjchem-2615	264	8	is	be	AUX
eurjchem-2615	264	9	associated	associate	VERB
eurjchem-2615	264	10	with	with	ADP
eurjchem-2615	264	11	adverse	adverse	ADJ
eurjchem-2615	264	12	effects	effect	NOUN
eurjchem-2615	264	13	,	,	PUNCT
eurjchem-2615	264	14	underscoring	underscore	VERB
eurjchem-2615	264	15	the	the	DET
eurjchem-2615	264	16	urgent	urgent	ADJ
eurjchem-2615	264	17	need	need	NOUN
eurjchem-2615	264	18	to	to	PART
eurjchem-2615	264	19	develop	develop	VERB
eurjchem-2615	264	20	novel	novel	ADJ
eurjchem-2615	264	21	compounds	compound	NOUN
eurjchem-2615	264	22	within	within	ADP
eurjchem-2615	264	23	this	this	DET
eurjchem-2615	264	24	class	class	NOUN
eurjchem-2615	264	25	that	that	PRON
eurjchem-2615	264	26	exhibit	exhibit	VERB
eurjchem-2615	264	27	improved	improved	ADJ
eurjchem-2615	264	28	efficacy	efficacy	NOUN
eurjchem-2615	264	29	.	.	PUNCT
eurjchem-2615	265	1	in	in	ADP
eurjchem-2615	265	2	this	this	DET
eurjchem-2615	265	3	context	context	NOUN
eurjchem-2615	265	4	,	,	PUNCT
eurjchem-2615	265	5	a	a	DET
eurjchem-2615	265	6	1,2,3	1,2,3	NUM
eurjchem-2615	265	7	-	-	ADJ
eurjchem-2615	265	8	triazole	triazole	ADJ
eurjchem-2615	265	9	oxazolidinone	oxazolidinone	NOUN
eurjchem-2615	265	10	hybrid	hybrid	NOUN
eurjchem-2615	265	11	,	,	PUNCT
eurjchem-2615	265	12	designated	designate	VERB
eurjchem-2615	265	13	as	as	ADP
eurjchem-2615	265	14	compound	compound	NOUN
eurjchem-2615	265	15	39	39	NUM
eurjchem-2615	265	16	,	,	PUNCT
eurjchem-2615	265	17	has	have	AUX
eurjchem-2615	265	18	been	be	AUX
eurjchem-2615	265	19	synthesized	synthesize	VERB
eurjchem-2615	265	20	by	by	ADP
eurjchem-2615	265	21	modifying	modify	VERB
eurjchem-2615	265	22	the	the	DET
eurjchem-2615	265	23	morpholine	morpholine	ADJ
eurjchem-2615	265	24	ring	ring	NOUN
eurjchem-2615	265	25	of	of	ADP
eurjchem-2615	265	26	linezolid	linezolid	NOUN
eurjchem-2615	265	27	and	and	CCONJ
eurjchem-2615	265	28	replacing	replace	VERB
eurjchem-2615	265	29	the	the	DET
eurjchem-2615	265	30	amide	amide	NOUN
eurjchem-2615	265	31	group	group	NOUN
eurjchem-2615	265	32	with	with	ADP
eurjchem-2615	265	33	its	its	PRON
eurjchem-2615	265	34	bioisosteric	bioisosteric	ADJ
eurjchem-2615	265	35	1,2,3	1,2,3	NUM
eurjchem-2615	265	36	-	-	NOUN
eurjchem-2615	265	37	triazole	triazole	NOUN
eurjchem-2615	265	38	.	.	PUNCT
eurjchem-2615	266	1	this	this	DET
eurjchem-2615	266	2	modification	modification	NOUN
eurjchem-2615	266	3	resulted	result	VERB
eurjchem-2615	266	4	in	in	ADP
eurjchem-2615	266	5	a	a	DET
eurjchem-2615	266	6	compound	compound	NOUN
eurjchem-2615	266	7	exhibiting	exhibit	VERB
eurjchem-2615	266	8	potent	potent	ADJ
eurjchem-2615	266	9	activity	activity	NOUN
eurjchem-2615	266	10	against	against	ADP
eurjchem-2615	266	11	the	the	DET
eurjchem-2615	266	12	m.	m.	NOUN
eurjchem-2615	266	13	tuberculosis	tuberculosis	NOUN
eurjchem-2615	266	14	h37rv	h37rv	PROPN
eurjchem-2615	266	15	strain	strain	NOUN
eurjchem-2615	266	16	,	,	PUNCT
eurjchem-2615	266	17	with	with	ADP
eurjchem-2615	266	18	a	a	DET
eurjchem-2615	266	19	reduced	reduced	ADJ
eurjchem-2615	266	20	mic	mic	NOUN
eurjchem-2615	266	21	of	of	ADP
eurjchem-2615	266	22	0.5	0.5	NUM
eurjchem-2615	266	23	μg	μg	NOUN
eurjchem-2615	266	24	/	/	SYM
eurjchem-2615	266	25	ml	ml	PROPN
eurjchem-2615	267	1	[	[	X
eurjchem-2615	267	2	97	97	NUM
eurjchem-2615	267	3	]	]	PUNCT
eurjchem-2615	267	4	.	.	PUNCT
eurjchem-2615	268	1	furthermore	furthermore	ADV
eurjchem-2615	268	2	,	,	PUNCT
eurjchem-2615	268	3	a	a	DET
eurjchem-2615	268	4	diarylpyrroleoxazolidinone-1,2,3	diarylpyrroleoxazolidinone-1,2,3	ADJ
eurjchem-2615	268	5	-	-	PUNCT
eurjchem-2615	268	6	triazole	triazole	NOUN
eurjchem-2615	268	7	hybrid	hybrid	NOUN
eurjchem-2615	268	8	,	,	PUNCT
eurjchem-2615	268	9	known	know	VERB
eurjchem-2615	268	10	as	as	ADP
eurjchem-2615	268	11	compound	compound	NOUN
eurjchem-2615	268	12	40	40	NUM
eurjchem-2615	268	13	,	,	PUNCT
eurjchem-2615	268	14	has	have	AUX
eurjchem-2615	268	15	demonstrated	demonstrate	VERB
eurjchem-2615	268	16	significant	significant	ADJ
eurjchem-2615	268	17	antibacterial	antibacterial	ADJ
eurjchem-2615	268	18	activity	activity	NOUN
eurjchem-2615	268	19	against	against	ADP
eurjchem-2615	268	20	m.	m.	NOUN
eurjchem-2615	268	21	tuberculosis	tuberculosis	NOUN
eurjchem-2615	268	22	h37rv	h37rv	NOUN
eurjchem-2615	268	23	,	,	PUNCT
eurjchem-2615	268	24	m.	m.	NOUN
eurjchem-2615	268	25	tuberculosis	tuberculosis	NOUN
eurjchem-2615	268	26	rifr	rifr	NOUN
eurjchem-2615	268	27	,	,	PUNCT
eurjchem-2615	268	28	and	and	CCONJ
eurjchem-2615	268	29	m.	m.	NOUN
eurjchem-2615	268	30	tuberculosis	tuberculosis	PROPN
eurjchem-2615	268	31	xdr	xdr	PROPN
eurjchem-2615	268	32	,	,	PUNCT
eurjchem-2615	268	33	with	with	ADP
eurjchem-2615	268	34	mic	mic	ADJ
eurjchem-2615	268	35	values	value	NOUN
eurjchem-2615	268	36	of	of	ADP
eurjchem-2615	268	37	2.0	2.0	NUM
eurjchem-2615	268	38	,	,	PUNCT
eurjchem-2615	268	39	4.0	4.0	NUM
eurjchem-2615	268	40	,	,	PUNCT
eurjchem-2615	268	41	and	and	CCONJ
eurjchem-2615	268	42	8.0	8.0	NUM
eurjchem-2615	268	43	μg	μg	NOUN
eurjchem-2615	268	44	/	/	SYM
eurjchem-2615	268	45	ml	ml	PROPN
eurjchem-2615	268	46	,	,	PUNCT
eurjchem-2615	268	47	respectively	respectively	ADV
eurjchem-2615	268	48	[	[	X
eurjchem-2615	268	49	98	98	NUM
eurjchem-2615	268	50	]	]	PUNCT
eurjchem-2615	268	51	.	.	PUNCT
eurjchem-2615	269	1	these	these	DET
eurjchem-2615	269	2	hybrid	hybrid	ADJ
eurjchem-2615	269	3	compounds	compound	NOUN
eurjchem-2615	269	4	have	have	AUX
eurjchem-2615	269	5	also	also	ADV
eurjchem-2615	269	6	shown	show	VERB
eurjchem-2615	269	7	nontoxicity	nontoxicity	NOUN
eurjchem-2615	269	8	against	against	ADP
eurjchem-2615	269	9	mouse	mouse	NOUN
eurjchem-2615	269	10	macrophage	macrophage	ADJ
eurjchem-2615	269	11	cells	cell	NOUN
eurjchem-2615	269	12	(	(	PUNCT
eurjchem-2615	269	13	j-774a	j-774a	PROPN
eurjchem-2615	269	14	)	)	PUNCT
eurjchem-2615	269	15	,	,	PUNCT
eurjchem-2615	269	16	with	with	ADP
eurjchem-2615	269	17	a	a	DET
eurjchem-2615	269	18	selectivity	selectivity	NOUN
eurjchem-2615	269	19	index	index	NOUN
eurjchem-2615	269	20	(	(	PUNCT
eurjchem-2615	269	21	si	si	NOUN
eurjchem-2615	269	22	)	)	PUNCT
eurjchem-2615	269	23	greater	great	ADJ
eurjchem-2615	269	24	than	than	ADP
eurjchem-2615	269	25	10	10	NUM
eurjchem-2615	269	26	,	,	PUNCT
eurjchem-2615	269	27	suggesting	suggest	VERB
eurjchem-2615	269	28	their	their	PRON
eurjchem-2615	269	29	potential	potential	NOUN
eurjchem-2615	269	30	as	as	SCONJ
eurjchem-2615	269	31	leads	lead	NOUN
eurjchem-2615	269	32	for	for	ADP
eurjchem-2615	269	33	the	the	DET
eurjchem-2615	269	34	optimization	optimization	NOUN
eurjchem-2615	269	35	of	of	ADP
eurjchem-2615	269	36	new	new	ADJ
eurjchem-2615	269	37	antitubercular	antitubercular	ADJ
eurjchem-2615	269	38	drugs	drug	NOUN
eurjchem-2615	269	39	.	.	PUNCT
eurjchem-2615	270	1	additionally	additionally	ADV
eurjchem-2615	270	2	,	,	PUNCT
eurjchem-2615	270	3	a	a	DET
eurjchem-2615	270	4	simple	simple	ADJ
eurjchem-2615	270	5	1,2,3	1,2,3	NUM
eurjchem-2615	270	6	-	-	ADJ
eurjchem-2615	270	7	triazole	triazole	ADJ
eurjchem-2615	270	8	derivative	derivative	NOUN
eurjchem-2615	270	9	,	,	PUNCT
eurjchem-2615	270	10	compound	compound	NOUN
eurjchem-2615	270	11	41	41	NUM
eurjchem-2615	270	12	,	,	PUNCT
eurjchem-2615	270	13	has	have	AUX
eurjchem-2615	270	14	shown	show	VERB
eurjchem-2615	270	15	notable	notable	ADJ
eurjchem-2615	270	16	activity	activity	NOUN
eurjchem-2615	270	17	against	against	ADP
eurjchem-2615	270	18	the	the	DET
eurjchem-2615	270	19	m.	m.	NOUN
eurjchem-2615	270	20	tuberculosis	tuberculosis	NOUN
eurjchem-2615	270	21	h37rv	h37rv	PROPN
eurjchem-2615	270	22	strain	strain	NOUN
eurjchem-2615	270	23	,	,	PUNCT
eurjchem-2615	270	24	with	with	ADP
eurjchem-2615	270	25	a	a	DET
eurjchem-2615	270	26	mic	mic	NOUN
eurjchem-2615	270	27	of	of	ADP
eurjchem-2615	270	28	3.75	3.75	NUM
eurjchem-2615	270	29	μg	μg	PROPN
eurjchem-2615	270	30	/	/	SYM
eurjchem-2615	270	31	ml	ml	NOUN
eurjchem-2615	270	32	,	,	PUNCT
eurjchem-2615	270	33	which	which	PRON
eurjchem-2615	270	34	is	be	AUX
eurjchem-2615	270	35	comparable	comparable	ADJ
eurjchem-2615	270	36	to	to	ADP
eurjchem-2615	270	37	the	the	DET
eurjchem-2615	270	38	activity	activity	NOUN
eurjchem-2615	270	39	of	of	ADP
eurjchem-2615	270	40	the	the	DET
eurjchem-2615	270	41	standard	standard	ADJ
eurjchem-2615	270	42	anti	anti	ADJ
eurjchem-2615	270	43	-	-	ADJ
eurjchem-2615	270	44	tb	tb	ADJ
eurjchem-2615	270	45	drug	drug	NOUN
eurjchem-2615	270	46	,	,	PUNCT
eurjchem-2615	270	47	isoniazid	isoniazid	NOUN
eurjchem-2615	270	48	[	[	X
eurjchem-2615	270	49	99	99	NUM
eurjchem-2615	270	50	]	]	PUNCT
eurjchem-2615	270	51	.	.	PUNCT
eurjchem-2615	271	1	this	this	DET
eurjchem-2615	271	2	finding	finding	NOUN
eurjchem-2615	271	3	underscores	underscore	VERB
eurjchem-2615	271	4	the	the	DET
eurjchem-2615	271	5	potential	potential	NOUN
eurjchem-2615	271	6	of	of	ADP
eurjchem-2615	271	7	these	these	DET
eurjchem-2615	271	8	chemical	chemical	ADJ
eurjchem-2615	271	9	modifications	modification	NOUN
eurjchem-2615	271	10	to	to	PART
eurjchem-2615	271	11	improve	improve	VERB
eurjchem-2615	271	12	the	the	DET
eurjchem-2615	271	13	efficacy	efficacy	NOUN
eurjchem-2615	271	14	of	of	ADP
eurjchem-2615	271	15	antitubercular	antitubercular	ADJ
eurjchem-2615	271	16	agents	agent	NOUN
eurjchem-2615	271	17	and	and	CCONJ
eurjchem-2615	271	18	warrants	warrant	NOUN
eurjchem-2615	271	19	further	further	ADJ
eurjchem-2615	271	20	exploration	exploration	NOUN
eurjchem-2615	271	21	for	for	ADP
eurjchem-2615	271	22	the	the	DET
eurjchem-2615	271	23	development	development	NOUN
eurjchem-2615	271	24	of	of	ADP
eurjchem-2615	271	25	more	more	ADV
eurjchem-2615	271	26	effective	effective	ADJ
eurjchem-2615	271	27	tuberculosis	tuberculosis	NOUN
eurjchem-2615	271	28	therapies	therapy	NOUN
eurjchem-2615	271	29	.	.	PUNCT
eurjchem-2615	272	1	the	the	DET
eurjchem-2615	272	2	1,4	1,4	NUM
eurjchem-2615	272	3	-	-	PUNCT
eurjchem-2615	272	4	disubstituted-1,2,3	disubstituted-1,2,3	ADJ
eurjchem-2615	272	5	-	-	PUNCT
eurjchem-2615	272	6	triazolyl	triazolyl	ADJ
eurjchem-2615	272	7	fatty	fatty	NOUN
eurjchem-2615	272	8	esters	ester	NOUN
eurjchem-2615	272	9	,	,	PUNCT
eurjchem-2615	272	10	specifically	specifically	ADV
eurjchem-2615	272	11	compounds	compound	VERB
eurjchem-2615	272	12	42a	42a	NOUN
eurjchem-2615	272	13	and	and	CCONJ
eurjchem-2615	272	14	42b	42b	NOUN
eurjchem-2615	272	15	,	,	PUNCT
eurjchem-2615	272	16	with	with	ADP
eurjchem-2615	272	17	mic	mic	ADJ
eurjchem-2615	272	18	values	value	NOUN
eurjchem-2615	272	19	of	of	ADP
eurjchem-2615	272	20	1.9	1.9	NUM
eurjchem-2615	272	21	and	and	CCONJ
eurjchem-2615	272	22	1.7	1.7	NUM
eurjchem-2615	272	23	μm	μm	NOUN
eurjchem-2615	272	24	respectively	respectively	ADV
eurjchem-2615	272	25	,	,	PUNCT
eurjchem-2615	272	26	have	have	AUX
eurjchem-2615	272	27	demonstrated	demonstrate	VERB
eurjchem-2615	272	28	significant	significant	ADJ
eurjchem-2615	272	29	antituberculosis	antituberculosis	NOUN
eurjchem-2615	272	30	activity	activity	NOUN
eurjchem-2615	272	31	against	against	ADP
eurjchem-2615	272	32	the	the	DET
eurjchem-2615	272	33	m.	m.	NOUN
eurjchem-2615	272	34	tuberculosis	tuberculosis	NOUN
eurjchem-2615	272	35	h37rv	h37rv	PROPN
eurjchem-2615	272	36	strain	strain	NOUN
eurjchem-2615	272	37	,	,	PUNCT
eurjchem-2615	272	38	as	as	SCONJ
eurjchem-2615	272	39	reported	report	VERB
eurjchem-2615	272	40	in	in	ADP
eurjchem-2615	272	41	reference	reference	NOUN
eurjchem-2615	272	42	[	[	X
eurjchem-2615	272	43	100	100	NUM
eurjchem-2615	272	44	]	]	PUNCT
eurjchem-2615	272	45	.	.	PUNCT
eurjchem-2615	273	1	structure	structure	NOUN
eurjchem-2615	273	2	-	-	PUNCT
eurjchem-2615	273	3	activity	activity	NOUN
eurjchem-2615	273	4	relationship	relationship	NOUN
eurjchem-2615	273	5	(	(	PUNCT
eurjchem-2615	273	6	sar	sar	PROPN
eurjchem-2615	273	7	)	)	PUNCT
eurjchem-2615	273	8	analysis	analysis	NOUN
eurjchem-2615	273	9	has	have	AUX
eurjchem-2615	273	10	indicated	indicate	VERB
eurjchem-2615	273	11	that	that	SCONJ
eurjchem-2615	273	12	the	the	DET
eurjchem-2615	273	13	length	length	NOUN
eurjchem-2615	273	14	of	of	ADP
eurjchem-2615	273	15	the	the	DET
eurjchem-2615	273	16	alkyl	alkyl	NOUN
eurjchem-2615	273	17	chain	chain	NOUN
eurjchem-2615	273	18	attached	attach	VERB
eurjchem-2615	273	19	at	at	ADP
eurjchem-2615	273	20	the	the	DET
eurjchem-2615	273	21	fourth	fourth	ADJ
eurjchem-2615	273	22	position	position	NOUN
eurjchem-2615	273	23	of	of	ADP
eurjchem-2615	273	24	the	the	DET
eurjchem-2615	273	25	triazole	triazole	NOUN
eurjchem-2615	273	26	ring	ring	NOUN
eurjchem-2615	273	27	plays	play	VERB
eurjchem-2615	273	28	a	a	DET
eurjchem-2615	273	29	key	key	ADJ
eurjchem-2615	273	30	role	role	NOUN
eurjchem-2615	273	31	in	in	ADP
eurjchem-2615	273	32	determining	determine	VERB
eurjchem-2615	273	33	the	the	DET
eurjchem-2615	273	34	activity	activity	NOUN
eurjchem-2615	273	35	of	of	ADP
eurjchem-2615	273	36	the	the	DET
eurjchem-2615	273	37	compounds	compound	NOUN
eurjchem-2615	273	38	.	.	PUNCT
eurjchem-2615	274	1	additionally	additionally	ADV
eurjchem-2615	274	2	,	,	PUNCT
eurjchem-2615	274	3	ester	ester	NOUN
eurjchem-2615	274	4	derivatives	derivative	NOUN
eurjchem-2615	274	5	have	have	AUX
eurjchem-2615	274	6	been	be	AUX
eurjchem-2615	274	7	observed	observe	VERB
eurjchem-2615	274	8	to	to	PART
eurjchem-2615	274	9	exhibit	exhibit	VERB
eurjchem-2615	274	10	higher	high	ADJ
eurjchem-2615	274	11	potency	potency	NOUN
eurjchem-2615	274	12	compared	compare	VERB
eurjchem-2615	274	13	to	to	ADP
eurjchem-2615	274	14	those	those	PRON
eurjchem-2615	274	15	of	of	ADP
eurjchem-2615	274	16	their	their	PRON
eurjchem-2615	274	17	corresponding	correspond	VERB
eurjchem-2615	274	18	acid	acid	NOUN
eurjchem-2615	274	19	or	or	CCONJ
eurjchem-2615	274	20	alcohol	alcohol	NOUN
eurjchem-2615	274	21	forms	form	NOUN
eurjchem-2615	274	22	.	.	PUNCT
eurjchem-2615	275	1	furthermore	furthermore	ADV
eurjchem-2615	275	2	,	,	PUNCT
eurjchem-2615	275	3	the	the	DET
eurjchem-2615	275	4	study	study	NOUN
eurjchem-2615	275	5	has	have	AUX
eurjchem-2615	275	6	shown	show	VERB
eurjchem-2615	275	7	that	that	SCONJ
eurjchem-2615	275	8	1,4	1,4	ADV
eurjchem-2615	275	9	-	-	PUNCT
eurjchem-2615	275	10	substituted	substitute	VERB
eurjchem-2615	275	11	triazoles	triazole	NOUN
eurjchem-2615	275	12	possess	possess	VERB
eurjchem-2615	275	13	a	a	DET
eurjchem-2615	275	14	superior	superior	ADJ
eurjchem-2615	275	15	antituberculosis	antituberculosis	NOUN
eurjchem-2615	275	16	potency	potency	NOUN
eurjchem-2615	275	17	over	over	ADP
eurjchem-2615	275	18	their	their	PRON
eurjchem-2615	275	19	1,5	1,5	NUM
eurjchem-2615	275	20	-	-	PUNCT
eurjchem-2615	275	21	substituted	substitute	VERB
eurjchem-2615	275	22	counterparts	counterpart	NOUN
eurjchem-2615	275	23	.	.	PUNCT
eurjchem-2615	276	1	these	these	DET
eurjchem-2615	276	2	findings	finding	NOUN
eurjchem-2615	276	3	underscore	underscore	VERB
eurjchem-2615	276	4	the	the	DET
eurjchem-2615	276	5	importance	importance	NOUN
eurjchem-2615	276	6	of	of	ADP
eurjchem-2615	276	7	structural	structural	ADJ
eurjchem-2615	276	8	modifications	modification	NOUN
eurjchem-2615	276	9	in	in	ADP
eurjchem-2615	276	10	enhancing	enhance	VERB
eurjchem-2615	276	11	the	the	DET
eurjchem-2615	276	12	efficacy	efficacy	NOUN
eurjchem-2615	276	13	of	of	ADP
eurjchem-2615	276	14	antituberculosis	antituberculosis	NOUN
eurjchem-2615	276	15	agents	agent	NOUN
eurjchem-2615	276	16	.	.	PUNCT
eurjchem-2615	277	1	zimo	zimo	VERB
eurjchem-2615	277	2	and	and	CCONJ
eurjchem-2615	277	3	coghi	coghi	PROPN
eurjchem-2615	277	4	/	/	SYM
eurjchem-2615	277	5	european	european	PROPN
eurjchem-2615	277	6	journal	journal	PROPN
eurjchem-2615	277	7	of	of	ADP
eurjchem-2615	277	8	chemistry	chemistry	NOUN
eurjchem-2615	277	9	16	16	NUM
eurjchem-2615	277	10	(	(	PUNCT
eurjchem-2615	277	11	1	1	NUM
eurjchem-2615	277	12	)	)	PUNCT
eurjchem-2615	277	13	(	(	PUNCT
eurjchem-2615	277	14	2025	2025	NUM
eurjchem-2615	277	15	)	)	PUNCT
eurjchem-2615	277	16	83	83	NUM
eurjchem-2615	277	17	-	-	SYM
eurjchem-2615	277	18	96	96	NUM
eurjchem-2615	277	19	93	93	NUM
eurjchem-2615	277	20	2025	2025	NUM
eurjchem-2615	277	21	–	–	PUNCT
eurjchem-2615	277	22	european	european	ADJ
eurjchem-2615	277	23	journal	journal	NOUN
eurjchem-2615	277	24	of	of	ADP
eurjchem-2615	277	25	chemistry	chemistry	NOUN
eurjchem-2615	277	26	–	–	PUNCT
eurjchem-2615	277	27	cc	cc	NOUN
eurjchem-2615	277	28	by	by	ADP
eurjchem-2615	277	29	nc	nc	PROPN
eurjchem-2615	277	30	–	–	PUNCT
eurjchem-2615	277	31	doi	doi	NOUN
eurjchem-2615	277	32	:	:	PUNCT
eurjchem-2615	277	33	10.5155	10.5155	NUM
eurjchem-2615	277	34	/	/	SYM
eurjchem-2615	277	35	eurjchem.16.1.83	eurjchem.16.1.83	ADJ
eurjchem-2615	277	36	-	-	PUNCT
eurjchem-2615	277	37	96.2615	96.2615	NUM
eurjchem-2615	277	38	figure	figure	NOUN
eurjchem-2615	277	39	12	12	NUM
eurjchem-2615	277	40	.	.	PUNCT
eurjchem-2615	278	1	structure	structure	NOUN
eurjchem-2615	278	2	of	of	ADP
eurjchem-2615	278	3	some	some	DET
eurjchem-2615	278	4	miscellaneous	miscellaneous	ADJ
eurjchem-2615	278	5	1,2,3	1,2,3	NUM
eurjchem-2615	278	6	-	-	PUNCT
eurjchem-2615	278	7	triazole	triazole	ADJ
eurjchem-2615	278	8	hybrids	hybrid	NOUN
eurjchem-2615	278	9	36	36	NUM
eurjchem-2615	278	10	-	-	SYM
eurjchem-2615	278	11	44	44	NUM
eurjchem-2615	278	12	as	as	ADP
eurjchem-2615	278	13	potential	potential	ADJ
eurjchem-2615	278	14	antitubercular	antitubercular	ADJ
eurjchem-2615	278	15	activity	activity	NOUN
eurjchem-2615	278	16	.	.	PUNCT
eurjchem-2615	279	1	compounds	compound	VERB
eurjchem-2615	279	2	43a	43a	NOUN
eurjchem-2615	279	3	and	and	CCONJ
eurjchem-2615	279	4	43b	43b	NOUN
eurjchem-2615	279	5	,	,	PUNCT
eurjchem-2615	279	6	which	which	PRON
eurjchem-2615	279	7	are	be	AUX
eurjchem-2615	279	8	1,2,3	1,2,3	NUM
eurjchem-2615	279	9	-	-	PUNCT
eurjchem-2615	279	10	triazolyl	triazolyl	ADJ
eurjchem-2615	279	11	xanthenones	xanthenone	NOUN
eurjchem-2615	279	12	,	,	PUNCT
eurjchem-2615	279	13	have	have	AUX
eurjchem-2615	279	14	shown	show	VERB
eurjchem-2615	279	15	a	a	DET
eurjchem-2615	279	16	range	range	NOUN
eurjchem-2615	279	17	of	of	ADP
eurjchem-2615	279	18	modest	modest	ADJ
eurjchem-2615	279	19	to	to	ADP
eurjchem-2615	279	20	significant	significant	ADJ
eurjchem-2615	279	21	antituberculosis	antituberculosis	NOUN
eurjchem-2615	279	22	activity	activity	NOUN
eurjchem-2615	279	23	against	against	ADP
eurjchem-2615	279	24	the	the	DET
eurjchem-2615	279	25	m.	m.	NOUN
eurjchem-2615	279	26	tuberculosis	tuberculosis	NOUN
eurjchem-2615	279	27	h37rv	h37rv	PROPN
eurjchem-2615	279	28	strain	strain	NOUN
eurjchem-2615	279	29	,	,	PUNCT
eurjchem-2615	279	30	with	with	ADP
eurjchem-2615	279	31	minimum	minimum	ADJ
eurjchem-2615	279	32	inhibitory	inhibitory	ADJ
eurjchem-2615	279	33	concentrations	concentration	NOUN
eurjchem-2615	279	34	(	(	PUNCT
eurjchem-2615	279	35	mics	mic	NOUN
eurjchem-2615	279	36	)	)	PUNCT
eurjchem-2615	279	37	ranging	range	VERB
eurjchem-2615	279	38	from	from	ADP
eurjchem-2615	279	39	3.125	3.125	NUM
eurjchem-2615	279	40	μg	μg	NOUN
eurjchem-2615	279	41	/	/	SYM
eurjchem-2615	279	42	ml	ml	NOUN
eurjchem-2615	279	43	to	to	ADP
eurjchem-2615	279	44	≥25	≥25	PROPN
eurjchem-2615	279	45	μg	μg	PROPN
eurjchem-2615	279	46	/	/	SYM
eurjchem-2615	279	47	ml	ml	PROPN
eurjchem-2615	279	48	,	,	PUNCT
eurjchem-2615	279	49	and	and	CCONJ
eurjchem-2615	279	50	have	have	AUX
eurjchem-2615	279	51	been	be	AUX
eurjchem-2615	279	52	found	find	VERB
eurjchem-2615	279	53	to	to	PART
eurjchem-2615	279	54	be	be	AUX
eurjchem-2615	279	55	cytotoxic	cytotoxic	ADJ
eurjchem-2615	279	56	against	against	ADP
eurjchem-2615	279	57	hek	hek	PROPN
eurjchem-2615	279	58	cell	cell	NOUN
eurjchem-2615	279	59	lines	line	NOUN
eurjchem-2615	279	60	,	,	PUNCT
eurjchem-2615	279	61	as	as	SCONJ
eurjchem-2615	279	62	documented	document	VERB
eurjchem-2615	279	63	in	in	ADP
eurjchem-2615	279	64	reference	reference	NOUN
eurjchem-2615	279	65	[	[	X
eurjchem-2615	279	66	101	101	NUM
eurjchem-2615	279	67	]	]	PUNCT
eurjchem-2615	279	68	.	.	PUNCT
eurjchem-2615	280	1	structure	structure	NOUN
eurjchem-2615	280	2	-	-	PUNCT
eurjchem-2615	280	3	activity	activity	NOUN
eurjchem-2615	280	4	relationship	relationship	NOUN
eurjchem-2615	280	5	(	(	PUNCT
eurjchem-2615	280	6	sar	sar	PROPN
eurjchem-2615	280	7	)	)	PUNCT
eurjchem-2615	280	8	studies	study	NOUN
eurjchem-2615	280	9	have	have	AUX
eurjchem-2615	280	10	highlighted	highlight	VERB
eurjchem-2615	280	11	that	that	DET
eurjchem-2615	280	12	substitution	substitution	NOUN
eurjchem-2615	280	13	at	at	ADP
eurjchem-2615	280	14	the	the	DET
eurjchem-2615	280	15	4	4	NUM
eurjchem-2615	280	16	-	-	PUNCT
eurjchem-2615	280	17	position	position	NOUN
eurjchem-2615	280	18	(	(	PUNCT
eurjchem-2615	280	19	specifically	specifically	ADV
eurjchem-2615	280	20	4	4	NUM
eurjchem-2615	280	21	-	-	PUNCT
eurjchem-2615	280	22	cl	cl	NOUN
eurjchem-2615	280	23	and	and	CCONJ
eurjchem-2615	280	24	4	4	NUM
eurjchem-2615	280	25	-	-	PUNCT
eurjchem-2615	280	26	ome	ome	NOUN
eurjchem-2615	280	27	)	)	PUNCT
eurjchem-2615	280	28	on	on	ADP
eurjchem-2615	280	29	the	the	DET
eurjchem-2615	280	30	triazole	triazole	NOUN
eurjchem-2615	280	31	ring	ring	NOUN
eurjchem-2615	280	32	(	(	PUNCT
eurjchem-2615	280	33	designated	designate	VERB
eurjchem-2615	280	34	as	as	ADP
eurjchem-2615	280	35	the	the	DET
eurjchem-2615	280	36	r1	r1	PROPN
eurjchem-2615	280	37	position	position	NOUN
eurjchem-2615	280	38	)	)	PUNCT
eurjchem-2615	280	39	significantly	significantly	ADV
eurjchem-2615	280	40	influences	influence	VERB
eurjchem-2615	280	41	the	the	DET
eurjchem-2615	280	42	potency	potency	NOUN
eurjchem-2615	280	43	of	of	ADP
eurjchem-2615	280	44	the	the	DET
eurjchem-2615	280	45	compounds	compound	NOUN
eurjchem-2615	280	46	.	.	PUNCT
eurjchem-2615	281	1	the	the	DET
eurjchem-2615	281	2	mic	mic	ADJ
eurjchem-2615	281	3	values	value	NOUN
eurjchem-2615	281	4	of	of	ADP
eurjchem-2615	281	5	the	the	DET
eurjchem-2615	281	6	hybrid	hybrid	ADJ
eurjchem-2615	281	7	compounds	compound	NOUN
eurjchem-2615	281	8	43a	43a	NOUN
eurjchem-2615	281	9	and	and	CCONJ
eurjchem-2615	281	10	43b	43b	NOUN
eurjchem-2615	281	11	,	,	PUNCT
eurjchem-2615	281	12	both	both	PRON
eurjchem-2615	281	13	at	at	ADP
eurjchem-2615	281	14	3.125	3.125	NUM
eurjchem-2615	281	15	μg	μg	NOUN
eurjchem-2615	281	16	/	/	SYM
eurjchem-2615	281	17	ml	ml	PROPN
eurjchem-2615	281	18	,	,	PUNCT
eurjchem-2615	281	19	have	have	AUX
eurjchem-2615	281	20	confirmed	confirm	VERB
eurjchem-2615	281	21	that	that	SCONJ
eurjchem-2615	281	22	an	an	DET
eurjchem-2615	281	23	r1	r1	NOUN
eurjchem-2615	281	24	substitution	substitution	NOUN
eurjchem-2615	281	25	of	of	ADP
eurjchem-2615	281	26	4	4	NUM
eurjchem-2615	281	27	-	-	PUNCT
eurjchem-2615	281	28	cl	cl	NOUN
eurjchem-2615	281	29	is	be	AUX
eurjchem-2615	281	30	optimal	optimal	ADJ
eurjchem-2615	281	31	for	for	ADP
eurjchem-2615	281	32	activity	activity	NOUN
eurjchem-2615	281	33	.	.	PUNCT
eurjchem-2615	282	1	furthermore	furthermore	ADV
eurjchem-2615	282	2	,	,	PUNCT
eurjchem-2615	282	3	it	it	PRON
eurjchem-2615	282	4	has	have	AUX
eurjchem-2615	282	5	been	be	AUX
eurjchem-2615	282	6	observed	observe	VERB
eurjchem-2615	282	7	that	that	SCONJ
eurjchem-2615	282	8	the	the	DET
eurjchem-2615	282	9	presence	presence	NOUN
eurjchem-2615	282	10	of	of	ADP
eurjchem-2615	282	11	methyl	methyl	NOUN
eurjchem-2615	282	12	groups	group	NOUN
eurjchem-2615	282	13	on	on	ADP
eurjchem-2615	282	14	the	the	DET
eurjchem-2615	282	15	1,3	1,3	NUM
eurjchem-2615	282	16	-	-	PUNCT
eurjchem-2615	282	17	cyclodione	cyclodione	VERB
eurjchem-2615	282	18	moiety	moiety	NOUN
eurjchem-2615	282	19	does	do	AUX
eurjchem-2615	282	20	not	not	PART
eurjchem-2615	282	21	affect	affect	VERB
eurjchem-2615	282	22	the	the	DET
eurjchem-2615	282	23	potency	potency	NOUN
eurjchem-2615	282	24	of	of	ADP
eurjchem-2615	282	25	these	these	DET
eurjchem-2615	282	26	compounds	compound	NOUN
eurjchem-2615	282	27	.	.	PUNCT
eurjchem-2615	283	1	these	these	DET
eurjchem-2615	283	2	insights	insight	NOUN
eurjchem-2615	283	3	into	into	ADP
eurjchem-2615	283	4	the	the	DET
eurjchem-2615	283	5	structure	structure	NOUN
eurjchem-2615	283	6	-	-	PUNCT
eurjchem-2615	283	7	activity	activity	NOUN
eurjchem-2615	283	8	relationship	relationship	NOUN
eurjchem-2615	283	9	are	be	AUX
eurjchem-2615	283	10	crucial	crucial	ADJ
eurjchem-2615	283	11	for	for	ADP
eurjchem-2615	283	12	the	the	DET
eurjchem-2615	283	13	design	design	NOUN
eurjchem-2615	283	14	of	of	ADP
eurjchem-2615	283	15	more	more	ADV
eurjchem-2615	283	16	effective	effective	ADJ
eurjchem-2615	283	17	antituberculosis	antituberculosis	NOUN
eurjchem-2615	283	18	agents	agent	NOUN
eurjchem-2615	283	19	.	.	PUNCT
eurjchem-2615	284	1	the	the	DET
eurjchem-2615	284	2	1,2,3	1,2,3	NUM
eurjchem-2615	284	3	-	-	PUNCT
eurjchem-2615	284	4	triazole	triazole	NOUN
eurjchem-2615	284	5	-	-	PUNCT
eurjchem-2615	284	6	linked	link	VERB
eurjchem-2615	284	7	diindolylmethane	diindolylmethane	NOUN
eurjchem-2615	284	8	derivative	derivative	NOUN
eurjchem-2615	284	9	,	,	PUNCT
eurjchem-2615	284	10	compound	compound	NOUN
eurjchem-2615	284	11	44	44	NUM
eurjchem-2615	284	12	,	,	PUNCT
eurjchem-2615	284	13	has	have	AUX
eurjchem-2615	284	14	exhibited	exhibit	VERB
eurjchem-2615	284	15	moderate	moderate	ADJ
eurjchem-2615	284	16	to	to	ADP
eurjchem-2615	284	17	significant	significant	ADJ
eurjchem-2615	284	18	activity	activity	NOUN
eurjchem-2615	284	19	against	against	ADP
eurjchem-2615	284	20	mycobacterium	mycobacterium	NOUN
eurjchem-2615	284	21	tuberculosis	tuberculosis	NOUN
eurjchem-2615	284	22	h37rv	h37rv	NOUN
eurjchem-2615	284	23	,	,	PUNCT
eurjchem-2615	284	24	affecting	affect	VERB
eurjchem-2615	284	25	both	both	CCONJ
eurjchem-2615	284	26	the	the	DET
eurjchem-2615	284	27	dormant	dormant	ADJ
eurjchem-2615	284	28	and	and	CCONJ
eurjchem-2615	284	29	active	active	ADJ
eurjchem-2615	284	30	stages	stage	NOUN
eurjchem-2615	284	31	of	of	ADP
eurjchem-2615	284	32	the	the	DET
eurjchem-2615	284	33	bacteria	bacteria	NOUN
eurjchem-2615	284	34	with	with	ADP
eurjchem-2615	284	35	an	an	DET
eurjchem-2615	284	36	ic50	ic50	PROPN
eurjchem-2615	284	37	of	of	ADP
eurjchem-2615	284	38	up	up	ADP
eurjchem-2615	284	39	to	to	PART
eurjchem-2615	284	40	1.0	1.0	NUM
eurjchem-2615	284	41	μg	μg	NOUN
eurjchem-2615	284	42	/	/	SYM
eurjchem-2615	284	43	ml	ml	NOUN
eurjchem-2615	284	44	,	,	PUNCT
eurjchem-2615	284	45	as	as	SCONJ
eurjchem-2615	284	46	reported	report	VERB
eurjchem-2615	284	47	in	in	ADP
eurjchem-2615	284	48	the	the	DET
eurjchem-2615	284	49	reference	reference	NOUN
eurjchem-2615	284	50	[	[	X
eurjchem-2615	284	51	102	102	NUM
eurjchem-2615	284	52	]	]	PUNCT
eurjchem-2615	284	53	.	.	PUNCT
eurjchem-2615	285	1	this	this	DET
eurjchem-2615	285	2	hybrid	hybrid	ADJ
eurjchem-2615	285	3	compound	compound	NOUN
eurjchem-2615	285	4	was	be	AUX
eurjchem-2615	285	5	particularly	particularly	ADV
eurjchem-2615	285	6	potent	potent	ADJ
eurjchem-2615	285	7	,	,	PUNCT
eurjchem-2615	285	8	with	with	ADP
eurjchem-2615	285	9	ic50	ic50	PROPN
eurjchem-2615	285	10	values	value	NOUN
eurjchem-2615	285	11	of	of	ADP
eurjchem-2615	285	12	1.0	1.0	NUM
eurjchem-2615	285	13	μg	μg	NOUN
eurjchem-2615	285	14	/	/	SYM
eurjchem-2615	285	15	ml	ml	X
eurjchem-2615	285	16	against	against	ADP
eurjchem-2615	285	17	the	the	DET
eurjchem-2615	285	18	active	active	ADJ
eurjchem-2615	285	19	state	state	NOUN
eurjchem-2615	285	20	and	and	CCONJ
eurjchem-2615	285	21	3.0	3.0	NUM
eurjchem-2615	285	22	μg	μg	NOUN
eurjchem-2615	285	23	/	/	SYM
eurjchem-2615	285	24	ml	ml	X
eurjchem-2615	285	25	against	against	ADP
eurjchem-2615	285	26	the	the	DET
eurjchem-2615	285	27	dormant	dormant	ADJ
eurjchem-2615	285	28	state	state	NOUN
eurjchem-2615	285	29	of	of	ADP
eurjchem-2615	285	30	tuberculosis	tuberculosis	NOUN
eurjchem-2615	285	31	.	.	PUNCT
eurjchem-2615	286	1	structure	structure	NOUN
eurjchem-2615	286	2	-	-	PUNCT
eurjchem-2615	286	3	activity	activity	NOUN
eurjchem-2615	286	4	relationship	relationship	NOUN
eurjchem-2615	286	5	(	(	PUNCT
eurjchem-2615	286	6	sar	sar	NOUN
eurjchem-2615	286	7	)	)	PUNCT
eurjchem-2615	286	8	analysis	analysis	NOUN
eurjchem-2615	286	9	of	of	ADP
eurjchem-2615	286	10	these	these	DET
eurjchem-2615	286	11	hybrid	hybrid	ADJ
eurjchem-2615	286	12	compounds	compound	NOUN
eurjchem-2615	286	13	has	have	AUX
eurjchem-2615	286	14	indicated	indicate	VERB
eurjchem-2615	286	15	that	that	SCONJ
eurjchem-2615	286	16	electron	electron	NOUN
eurjchem-2615	286	17	-	-	PUNCT
eurjchem-2615	286	18	withdrawing	withdraw	VERB
eurjchem-2615	286	19	groups	group	NOUN
eurjchem-2615	286	20	(	(	PUNCT
eurjchem-2615	286	21	ewgs	ewgs	ADJ
eurjchem-2615	286	22	)	)	PUNCT
eurjchem-2615	286	23	,	,	PUNCT
eurjchem-2615	286	24	such	such	ADJ
eurjchem-2615	286	25	as	as	ADP
eurjchem-2615	286	26	-no2	-no2	PROPN
eurjchem-2615	286	27	or	or	CCONJ
eurjchem-2615	286	28	halogen	halogen	NOUN
eurjchem-2615	286	29	atoms	atom	NOUN
eurjchem-2615	286	30	(	(	PUNCT
eurjchem-2615	286	31	-x	-x	X
eurjchem-2615	286	32	)	)	PUNCT
eurjchem-2615	286	33	,	,	PUNCT
eurjchem-2615	286	34	generally	generally	ADV
eurjchem-2615	286	35	enhance	enhance	VERB
eurjchem-2615	286	36	activity	activity	NOUN
eurjchem-2615	286	37	,	,	PUNCT
eurjchem-2615	286	38	while	while	SCONJ
eurjchem-2615	286	39	electron	electron	NOUN
eurjchem-2615	286	40	-	-	PUNCT
eurjchem-2615	286	41	donating	donate	VERB
eurjchem-2615	286	42	groups	group	NOUN
eurjchem-2615	286	43	(	(	PUNCT
eurjchem-2615	286	44	edgs	edgs	NOUN
eurjchem-2615	286	45	)	)	PUNCT
eurjchem-2615	286	46	,	,	PUNCT
eurjchem-2615	286	47	such	such	ADJ
eurjchem-2615	286	48	as	as	ADP
eurjchem-2615	286	49	-me	-me	NUM
eurjchem-2615	286	50	or	or	CCONJ
eurjchem-2615	286	51	-ome	-ome	NUM
eurjchem-2615	286	52	,	,	PUNCT
eurjchem-2615	286	53	tend	tend	VERB
eurjchem-2615	286	54	to	to	PART
eurjchem-2615	286	55	reduce	reduce	VERB
eurjchem-2615	286	56	the	the	DET
eurjchem-2615	286	57	bioactivity	bioactivity	NOUN
eurjchem-2615	286	58	.	.	PUNCT
eurjchem-2615	287	1	furthermore	furthermore	ADV
eurjchem-2615	287	2	,	,	PUNCT
eurjchem-2615	287	3	the	the	DET
eurjchem-2615	287	4	position	position	NOUN
eurjchem-2615	287	5	of	of	ADP
eurjchem-2615	287	6	the	the	DET
eurjchem-2615	287	7	substituents	substituent	NOUN
eurjchem-2615	287	8	on	on	ADP
eurjchem-2615	287	9	the	the	DET
eurjchem-2615	287	10	triazole	triazole	NOUN
eurjchem-2615	287	11	ring	ring	NOUN
eurjchem-2615	287	12	significantly	significantly	ADV
eurjchem-2615	287	13	influences	influence	VERB
eurjchem-2615	287	14	the	the	DET
eurjchem-2615	287	15	potency	potency	NOUN
eurjchem-2615	287	16	,	,	PUNCT
eurjchem-2615	287	17	with	with	ADP
eurjchem-2615	287	18	the	the	DET
eurjchem-2615	287	19	order	order	NOUN
eurjchem-2615	287	20	of	of	ADP
eurjchem-2615	287	21	activity	activity	NOUN
eurjchem-2615	287	22	being	be	AUX
eurjchem-2615	287	23	2	2	NUM
eurjchem-2615	287	24	-	-	PUNCT
eurjchem-2615	287	25	no2	no2	NOUN
eurjchem-2615	287	26	>	>	X
eurjchem-2615	287	27	3	3	NUM
eurjchem-2615	287	28	-	-	PUNCT
eurjchem-2615	287	29	no2	no2	NOUN
eurjchem-2615	287	30	>	>	X
eurjchem-2615	287	31	4	4	NUM
eurjchem-2615	287	32	-	-	PUNCT
eurjchem-2615	287	33	no2	no2	NOUN
eurjchem-2615	287	34	versus	versus	ADP
eurjchem-2615	287	35	both	both	CCONJ
eurjchem-2615	287	36	the	the	DET
eurjchem-2615	287	37	active	active	ADJ
eurjchem-2615	287	38	and	and	CCONJ
eurjchem-2615	287	39	dormant	dormant	VERB
eurjchem-2615	287	40	forms	form	NOUN
eurjchem-2615	287	41	of	of	ADP
eurjchem-2615	287	42	m.	m.	NOUN
eurjchem-2615	287	43	tuberculosis	tuberculosis	NOUN
eurjchem-2615	287	44	h37rv	h37rv	PROPN
eurjchem-2615	287	45	.	.	PUNCT
eurjchem-2615	288	1	these	these	DET
eurjchem-2615	288	2	findings	finding	NOUN
eurjchem-2615	288	3	provide	provide	VERB
eurjchem-2615	288	4	valuable	valuable	ADJ
eurjchem-2615	288	5	insights	insight	NOUN
eurjchem-2615	288	6	for	for	ADP
eurjchem-2615	288	7	the	the	DET
eurjchem-2615	288	8	optimization	optimization	NOUN
eurjchem-2615	288	9	of	of	ADP
eurjchem-2615	288	10	antituberculosis	antituberculosis	NOUN
eurjchem-2615	288	11	agents	agent	NOUN
eurjchem-2615	288	12	.	.	PUNCT
eurjchem-2615	289	1	94	94	NUM
eurjchem-2615	289	2	zimo	zimo	ADJ
eurjchem-2615	289	3	and	and	CCONJ
eurjchem-2615	289	4	coghi	coghi	PROPN
eurjchem-2615	289	5	/	/	SYM
eurjchem-2615	289	6	european	european	PROPN
eurjchem-2615	289	7	journal	journal	PROPN
eurjchem-2615	289	8	of	of	ADP
eurjchem-2615	289	9	chemistry	chemistry	NOUN
eurjchem-2615	289	10	16	16	NUM
eurjchem-2615	289	11	(	(	PUNCT
eurjchem-2615	289	12	1	1	NUM
eurjchem-2615	289	13	)	)	PUNCT
eurjchem-2615	289	14	(	(	PUNCT
eurjchem-2615	289	15	2025	2025	NUM
eurjchem-2615	289	16	)	)	PUNCT
eurjchem-2615	289	17	83	83	NUM
eurjchem-2615	289	18	-	-	SYM
eurjchem-2615	289	19	96	96	NUM
eurjchem-2615	289	20	2025	2025	NUM
eurjchem-2615	289	21	–	–	PUNCT
eurjchem-2615	289	22	european	european	ADJ
eurjchem-2615	289	23	journal	journal	NOUN
eurjchem-2615	289	24	of	of	ADP
eurjchem-2615	289	25	chemistry	chemistry	NOUN
eurjchem-2615	289	26	–	–	PUNCT
eurjchem-2615	289	27	cc	cc	NOUN
eurjchem-2615	289	28	by	by	ADP
eurjchem-2615	289	29	nc	nc	PROPN
eurjchem-2615	289	30	–	–	PUNCT
eurjchem-2615	289	31	doi	doi	NOUN
eurjchem-2615	289	32	:	:	PUNCT
eurjchem-2615	289	33	10.5155	10.5155	NUM
eurjchem-2615	289	34	/	/	SYM
eurjchem-2615	289	35	eurjchem.16.1.83	eurjchem.16.1.83	PROPN
eurjchem-2615	289	36	-	-	PUNCT
eurjchem-2615	289	37	96.2615	96.2615	NUM
eurjchem-2615	289	38	5	5	NUM
eurjchem-2615	289	39	.	.	PUNCT
eurjchem-2615	290	1	conclusions	conclusion	NOUN
eurjchem-2615	290	2	molecular	molecular	ADJ
eurjchem-2615	290	3	hybridization	hybridization	NOUN
eurjchem-2615	290	4	of	of	ADP
eurjchem-2615	290	5	1,2,3	1,2,3	NOUN
eurjchem-2615	290	6	-	-	NOUN
eurjchem-2615	290	7	triazoles	triazole	NOUN
eurjchem-2615	290	8	with	with	ADP
eurjchem-2615	290	9	bioactive	bioactive	ADJ
eurjchem-2615	290	10	scaffolds	scaffold	NOUN
eurjchem-2615	290	11	represents	represent	VERB
eurjchem-2615	290	12	a	a	DET
eurjchem-2615	290	13	crucial	crucial	ADJ
eurjchem-2615	290	14	strategy	strategy	NOUN
eurjchem-2615	290	15	for	for	ADP
eurjchem-2615	290	16	developing	develop	VERB
eurjchem-2615	290	17	novel	novel	ADJ
eurjchem-2615	290	18	antitubercular	antitubercular	ADJ
eurjchem-2615	290	19	agents	agent	NOUN
eurjchem-2615	290	20	.	.	PUNCT
eurjchem-2615	291	1	the	the	DET
eurjchem-2615	291	2	incorporation	incorporation	NOUN
eurjchem-2615	291	3	of	of	ADP
eurjchem-2615	291	4	triazoles	triazole	NOUN
eurjchem-2615	291	5	with	with	ADP
eurjchem-2615	291	6	pharmaceutically	pharmaceutically	ADV
eurjchem-2615	291	7	active	active	ADJ
eurjchem-2615	291	8	frameworks	framework	NOUN
eurjchem-2615	291	9	such	such	ADJ
eurjchem-2615	291	10	as	as	ADP
eurjchem-2615	291	11	azoles	azole	NOUN
eurjchem-2615	291	12	,	,	PUNCT
eurjchem-2615	291	13	coumarin	coumarin	NOUN
eurjchem-2615	291	14	/	/	SYM
eurjchem-2615	291	15	chromene	chromene	ADJ
eurjchem-2615	291	16	,	,	PUNCT
eurjchem-2615	291	17	isoniazid	isoniazid	NOUN
eurjchem-2615	291	18	,	,	PUNCT
eurjchem-2615	291	19	quinoline	quinoline	NOUN
eurjchem-2615	291	20	/	/	SYM
eurjchem-2615	291	21	dihydroquinoline	dihydroquinoline	NOUN
eurjchem-2615	291	22	,	,	PUNCT
eurjchem-2615	291	23	quinolone	quinolone	NOUN
eurjchem-2615	291	24	,	,	PUNCT
eurjchem-2615	291	25	ferrocene	ferrocene	NOUN
eurjchem-2615	291	26	,	,	PUNCT
eurjchem-2615	291	27	isatin	isatin	PROPN
eurjchem-2615	291	28	,	,	PUNCT
eurjchem-2615	291	29	furan	furan	PROPN
eurjchem-2615	291	30	,	,	PUNCT
eurjchem-2615	291	31	and	and	CCONJ
eurjchem-2615	291	32	others	other	NOUN
eurjchem-2615	291	33	has	have	AUX
eurjchem-2615	291	34	yielded	yield	VERB
eurjchem-2615	291	35	compounds	compound	NOUN
eurjchem-2615	291	36	with	with	ADP
eurjchem-2615	291	37	enhanced	enhanced	ADJ
eurjchem-2615	291	38	efficacy	efficacy	NOUN
eurjchem-2615	291	39	and	and	CCONJ
eurjchem-2615	291	40	improved	improve	VERB
eurjchem-2615	291	41	safety	safety	NOUN
eurjchem-2615	291	42	profiles	profile	NOUN
eurjchem-2615	291	43	compared	compare	VERB
eurjchem-2615	291	44	to	to	ADP
eurjchem-2615	291	45	those	those	PRON
eurjchem-2615	291	46	of	of	ADP
eurjchem-2615	291	47	parent	parent	NOUN
eurjchem-2615	291	48	molecules	molecule	NOUN
eurjchem-2615	291	49	.	.	PUNCT
eurjchem-2615	292	1	this	this	DET
eurjchem-2615	292	2	review	review	NOUN
eurjchem-2615	292	3	covers	cover	VERB
eurjchem-2615	292	4	the	the	DET
eurjchem-2615	292	5	innovations	innovation	NOUN
eurjchem-2615	292	6	of	of	ADP
eurjchem-2615	292	7	the	the	DET
eurjchem-2615	292	8	last	last	ADJ
eurjchem-2615	292	9	decade	decade	NOUN
eurjchem-2615	292	10	in	in	ADP
eurjchem-2615	292	11	triazole	triazole	NOUN
eurjchem-2615	292	12	-	-	PUNCT
eurjchem-2615	292	13	based	base	VERB
eurjchem-2615	292	14	antitubercular	antitubercular	ADJ
eurjchem-2615	292	15	drug	drug	NOUN
eurjchem-2615	292	16	development	development	NOUN
eurjchem-2615	292	17	,	,	PUNCT
eurjchem-2615	292	18	highlighting	highlight	VERB
eurjchem-2615	292	19	significant	significant	ADJ
eurjchem-2615	292	20	advances	advance	NOUN
eurjchem-2615	292	21	in	in	ADP
eurjchem-2615	292	22	both	both	PRON
eurjchem-2615	292	23	in	in	ADP
eurjchem-2615	292	24	vitro	vitro	X
eurjchem-2615	292	25	and	and	CCONJ
eurjchem-2615	292	26	in	in	ADP
eurjchem-2615	292	27	vivo	vivo	ADJ
eurjchem-2615	292	28	studies	study	NOUN
eurjchem-2615	292	29	.	.	PUNCT
eurjchem-2615	293	1	the	the	DET
eurjchem-2615	293	2	hybridization	hybridization	NOUN
eurjchem-2615	293	3	approach	approach	NOUN
eurjchem-2615	293	4	has	have	AUX
eurjchem-2615	293	5	successfully	successfully	ADV
eurjchem-2615	293	6	opened	open	VERB
eurjchem-2615	293	7	new	new	ADJ
eurjchem-2615	293	8	avenues	avenue	NOUN
eurjchem-2615	293	9	for	for	ADP
eurjchem-2615	293	10	the	the	DET
eurjchem-2615	293	11	development	development	NOUN
eurjchem-2615	293	12	of	of	ADP
eurjchem-2615	293	13	potent	potent	ADJ
eurjchem-2615	293	14	antitubercular	antitubercular	ADJ
eurjchem-2615	293	15	agents	agent	NOUN
eurjchem-2615	293	16	,	,	PUNCT
eurjchem-2615	293	17	providing	provide	VERB
eurjchem-2615	293	18	medicinal	medicinal	ADJ
eurjchem-2615	293	19	chemists	chemist	NOUN
eurjchem-2615	293	20	with	with	ADP
eurjchem-2615	293	21	valuable	valuable	ADJ
eurjchem-2615	293	22	insights	insight	NOUN
eurjchem-2615	293	23	for	for	ADP
eurjchem-2615	293	24	rational	rational	ADJ
eurjchem-2615	293	25	drug	drug	NOUN
eurjchem-2615	293	26	design	design	NOUN
eurjchem-2615	293	27	.	.	PUNCT
eurjchem-2615	294	1	comprehensive	comprehensive	PROPN
eurjchem-2615	294	2	sar	sar	PROPN
eurjchem-2615	294	3	studies	study	NOUN
eurjchem-2615	294	4	have	have	AUX
eurjchem-2615	294	5	illuminated	illuminate	VERB
eurjchem-2615	294	6	the	the	DET
eurjchem-2615	294	7	optimal	optimal	ADJ
eurjchem-2615	294	8	structural	structural	ADJ
eurjchem-2615	294	9	features	feature	NOUN
eurjchem-2615	294	10	,	,	PUNCT
eurjchem-2615	294	11	guiding	guide	VERB
eurjchem-2615	294	12	the	the	DET
eurjchem-2615	294	13	selection	selection	NOUN
eurjchem-2615	294	14	of	of	ADP
eurjchem-2615	294	15	substituents	substituent	NOUN
eurjchem-2615	294	16	and	and	CCONJ
eurjchem-2615	294	17	scaffolds	scaffold	NOUN
eurjchem-2615	294	18	to	to	PART
eurjchem-2615	294	19	maximize	maximize	VERB
eurjchem-2615	294	20	therapeutic	therapeutic	ADJ
eurjchem-2615	294	21	potential	potential	NOUN
eurjchem-2615	294	22	.	.	PUNCT
eurjchem-2615	295	1	these	these	DET
eurjchem-2615	295	2	insights	insight	NOUN
eurjchem-2615	295	3	facilitate	facilitate	VERB
eurjchem-2615	295	4	the	the	DET
eurjchem-2615	295	5	development	development	NOUN
eurjchem-2615	295	6	of	of	ADP
eurjchem-2615	295	7	compounds	compound	NOUN
eurjchem-2615	295	8	targeting	target	VERB
eurjchem-2615	295	9	both	both	CCONJ
eurjchem-2615	295	10	drugsensitive	drugsensitive	ADJ
eurjchem-2615	295	11	and	and	CCONJ
eurjchem-2615	295	12	resistant	resistant	ADJ
eurjchem-2615	295	13	tuberculosis	tuberculosis	NOUN
eurjchem-2615	295	14	strains	strain	NOUN
eurjchem-2615	295	15	(	(	PUNCT
eurjchem-2615	295	16	mdr	mdr	PROPN
eurjchem-2615	295	17	and	and	CCONJ
eurjchem-2615	295	18	xdr	xdr	PROPN
eurjchem-2615	295	19	-	-	PUNCT
eurjchem-2615	295	20	tb	tb	NOUN
eurjchem-2615	295	21	)	)	PUNCT
eurjchem-2615	295	22	,	,	PUNCT
eurjchem-2615	295	23	including	include	VERB
eurjchem-2615	295	24	cases	case	NOUN
eurjchem-2615	295	25	complicated	complicate	VERB
eurjchem-2615	295	26	by	by	ADP
eurjchem-2615	295	27	immunosuppressive	immunosuppressive	ADJ
eurjchem-2615	295	28	conditions	condition	NOUN
eurjchem-2615	295	29	.	.	PUNCT
eurjchem-2615	296	1	acknowledgements	acknowledgement	NOUN
eurjchem-2615	296	2	this	this	DET
eurjchem-2615	296	3	research	research	NOUN
eurjchem-2615	296	4	was	be	AUX
eurjchem-2615	296	5	supported	support	VERB
eurjchem-2615	296	6	by	by	ADP
eurjchem-2615	296	7	science	science	NOUN
eurjchem-2615	296	8	and	and	CCONJ
eurjchem-2615	296	9	technology	technology	NOUN
eurjchem-2615	296	10	development	development	NOUN
eurjchem-2615	296	11	fund	fund	NOUN
eurjchem-2615	296	12	fdct	fdct	NOUN
eurjchem-2615	296	13	grants	grant	NOUN
eurjchem-2615	296	14	of	of	ADP
eurjchem-2615	296	15	macau	macau	PROPN
eurjchem-2615	296	16	university	university	PROPN
eurjchem-2615	296	17	of	of	ADP
eurjchem-2615	296	18	science	science	NOUN
eurjchem-2615	296	19	and	and	CCONJ
eurjchem-2615	296	20	technology	technology	NOUN
eurjchem-2615	296	21	to	to	ADP
eurjchem-2615	296	22	pc	pc	NOUN
eurjchem-2615	296	23	(	(	PUNCT
eurjchem-2615	296	24	project	project	NOUN
eurjchem-2615	296	25	code	code	NOUN
eurjchem-2615	296	26	:	:	PUNCT
eurjchem-2615	296	27	0005	0005	NUM
eurjchem-2615	296	28	2023	2023	NUM
eurjchem-2615	296	29	-	-	PUNCT
eurjchem-2615	296	30	ria1	ria1	NOUN
eurjchem-2615	296	31	)	)	PUNCT
eurjchem-2615	296	32	.	.	PUNCT
eurjchem-2615	297	1	disclosure	disclosure	NOUN
eurjchem-2615	297	2	statement	statement	NOUN
eurjchem-2615	297	3	conflict	conflict	NOUN
eurjchem-2615	297	4	of	of	ADP
eurjchem-2615	297	5	interests	interest	NOUN
eurjchem-2615	297	6	:	:	PUNCT
eurjchem-2615	297	7	the	the	DET
eurjchem-2615	297	8	authors	author	NOUN
eurjchem-2615	297	9	declare	declare	VERB
eurjchem-2615	297	10	that	that	SCONJ
eurjchem-2615	297	11	they	they	PRON
eurjchem-2615	297	12	have	have	VERB
eurjchem-2615	297	13	no	no	DET
eurjchem-2615	297	14	conflict	conflict	NOUN
eurjchem-2615	297	15	of	of	ADP
eurjchem-2615	297	16	interest	interest	NOUN
eurjchem-2615	297	17	.	.	PUNCT
eurjchem-2615	298	1	ethical	ethical	ADJ
eurjchem-2615	298	2	approval	approval	NOUN
eurjchem-2615	298	3	:	:	PUNCT
eurjchem-2615	299	1	all	all	DET
eurjchem-2615	299	2	ethical	ethical	ADJ
eurjchem-2615	299	3	guidelines	guideline	NOUN
eurjchem-2615	299	4	have	have	AUX
eurjchem-2615	299	5	been	be	AUX
eurjchem-2615	299	6	adhered	adhere	VERB
eurjchem-2615	299	7	to	to	ADP
eurjchem-2615	299	8	.	.	PUNCT
eurjchem-2615	300	1	funding	fund	VERB
eurjchem-2615	300	2	fdct	fdct	PROPN
eurjchem-2615	300	3	http://dx.doi.org/10.13039/100006770	http://dx.doi.org/10.13039/100006770	PROPN
eurjchem-2615	300	4	abbreviations	abbreviation	NOUN
eurjchem-2615	300	5	sar	sar	NOUN
eurjchem-2615	300	6	:	:	PUNCT
eurjchem-2615	300	7	structure	structure	NOUN
eurjchem-2615	300	8	-	-	PUNCT
eurjchem-2615	300	9	activity	activity	NOUN
eurjchem-2615	300	10	relationship	relationship	NOUN
eurjchem-2615	300	11	;	;	PUNCT
eurjchem-2615	300	12	mdr	mdr	PROPN
eurjchem-2615	300	13	-	-	PROPN
eurjchem-2615	300	14	tb	tb	NOUN
eurjchem-2615	300	15	:	:	PUNCT
eurjchem-2615	300	16	multiple	multiple	ADJ
eurjchem-2615	300	17	-	-	PUNCT
eurjchem-2615	300	18	drug	drug	NOUN
eurjchem-2615	300	19	-	-	PUNCT
eurjchem-2615	300	20	resistant	resistant	ADJ
eurjchem-2615	300	21	tuberculosis	tuberculosis	NOUN
eurjchem-2615	300	22	;	;	PUNCT
eurjchem-2615	300	23	xdr	xdr	PROPN
eurjchem-2615	300	24	-	-	PUNCT
eurjchem-2615	300	25	tb	tb	PROPN
eurjchem-2615	300	26	:	:	PUNCT
eurjchem-2615	300	27	stands	stand	VERB
eurjchem-2615	300	28	for	for	ADP
eurjchem-2615	300	29	extensively	extensively	ADV
eurjchem-2615	300	30	drug	drug	NOUN
eurjchem-2615	300	31	-	-	PUNCT
eurjchem-2615	300	32	resistant	resistant	ADJ
eurjchem-2615	300	33	tuberculosis	tuberculosis	NOUN
eurjchem-2615	300	34	;	;	PUNCT
eurjchem-2615	300	35	cuaac	cuaac	NOUN
eurjchem-2615	300	36	:	:	PUNCT
eurjchem-2615	300	37	copper(i)-catalyzed	copper(i)-catalyze	VERB
eurjchem-2615	300	38	azide	azide	NOUN
eurjchem-2615	300	39	-	-	PUNCT
eurjchem-2615	300	40	alkyne	alkyne	NOUN
eurjchem-2615	300	41	cycloaddition	cycloaddition	NOUN
eurjchem-2615	300	42	;	;	PUNCT
eurjchem-2615	300	43	spaac	spaac	NOUN
eurjchem-2615	300	44	:	:	PUNCT
eurjchem-2615	300	45	strainpromoted	strainpromote	VERB
eurjchem-2615	300	46	azide	azide	NOUN
eurjchem-2615	300	47	-	-	PUNCT
eurjchem-2615	300	48	alkyne	alkyne	NOUN
eurjchem-2615	300	49	cycloaddition	cycloaddition	NOUN
eurjchem-2615	300	50	;	;	PUNCT
eurjchem-2615	300	51	inh	inh	PROPN
eurjchem-2615	300	52	:	:	PUNCT
eurjchem-2615	300	53	isonicotinic	isonicotinic	ADJ
eurjchem-2615	300	54	acid	acid	PROPN
eurjchem-2615	300	55	hydrazide	hydrazide	ADV
eurjchem-2615	300	56	;	;	PUNCT
eurjchem-2615	300	57	nad	nad	ADJ
eurjchem-2615	300	58	:	:	PUNCT
eurjchem-2615	300	59	nicotinamide	nicotinamide	NOUN
eurjchem-2615	300	60	adenine	adenine	ADJ
eurjchem-2615	300	61	dinucleotide	dinucleotide	NOUN
eurjchem-2615	300	62	;	;	PUNCT
eurjchem-2615	300	63	mic	mic	ADJ
eurjchem-2615	300	64	:	:	PUNCT
eurjchem-2615	300	65	minimum	minimum	ADJ
eurjchem-2615	300	66	inhibitory	inhibitory	ADJ
eurjchem-2615	300	67	concentrations	concentration	NOUN
eurjchem-2615	300	68	;	;	PUNCT
eurjchem-2615	300	69	mtb	mtb	NOUN
eurjchem-2615	300	70	:	:	PUNCT
eurjchem-2615	300	71	mycobacterium	mycobacterium	NOUN
eurjchem-2615	300	72	tuberculosis	tuberculosis	NOUN
eurjchem-2615	300	73	;	;	PUNCT
eurjchem-2615	300	74	mbta	mbta	PROPN
eurjchem-2615	300	75	:	:	PUNCT
eurjchem-2615	300	76	mycobactin	mycobactin	NOUN
eurjchem-2615	300	77	biosynthesis	biosynthesis	VERB
eurjchem-2615	300	78	protein	protein	NOUN
eurjchem-2615	300	79	a	a	PRON
eurjchem-2615	300	80	;	;	PUNCT
eurjchem-2615	300	81	mtb	mtb	NOUN
eurjchem-2615	300	82	-	-	PUNCT
eurjchem-2615	300	83	ps	ps	NOUN
eurjchem-2615	300	84	:	:	PUNCT
eurjchem-2615	300	85	mycobacterium	mycobacterium	NOUN
eurjchem-2615	300	86	tuberculosis	tuberculosis	NOUN
eurjchem-2615	300	87	pantothenate	pantothenate	NOUN
eurjchem-2615	300	88	synthetase	synthetase	NOUN
eurjchem-2615	300	89	;	;	PUNCT
eurjchem-2615	300	90	inha	inha	NOUN
eurjchem-2615	300	91	:	:	PUNCT
eurjchem-2615	300	92	enoyl	enoyl	PROPN
eurjchem-2615	300	93	-	-	PUNCT
eurjchem-2615	300	94	acp	acp	PROPN
eurjchem-2615	300	95	reductase	reductase	NOUN
eurjchem-2615	300	96	;	;	PUNCT
eurjchem-2615	300	97	ic50	ic50	PROPN
eurjchem-2615	300	98	:	:	PUNCT
eurjchem-2615	300	99	half	half	NOUN
eurjchem-2615	300	100	maximal	maximal	ADJ
eurjchem-2615	300	101	inhibitory	inhibitory	ADJ
eurjchem-2615	300	102	concentration	concentration	NOUN
eurjchem-2615	300	103	;	;	PUNCT
eurjchem-2615	300	104	mdl50	mdl50	NOUN
eurjchem-2615	300	105	:	:	PUNCT
eurjchem-2615	300	106	median	median	ADJ
eurjchem-2615	300	107	lethal	lethal	ADJ
eurjchem-2615	300	108	dose	dose	NOUN
eurjchem-2615	300	109	;	;	PUNCT
eurjchem-2615	300	110	cpfx	cpfx	NOUN
eurjchem-2615	300	111	:	:	PUNCT
eurjchem-2615	300	112	ciprofloxacin	ciprofloxacin	PROPN
eurjchem-2615	300	113	;	;	PUNCT
eurjchem-2615	300	114	gtfx	gtfx	PROPN
eurjchem-2615	300	115	:	:	PUNCT
eurjchem-2615	300	116	gatifloxacin	gatifloxacin	PROPN
eurjchem-2615	300	117	;	;	PUNCT
eurjchem-2615	300	118	mxfx	mxfx	NOUN
eurjchem-2615	300	119	:	:	PUNCT
eurjchem-2615	300	120	moxifloxacin	moxifloxacin	ADJ
eurjchem-2615	300	121	;	;	PUNCT
eurjchem-2615	300	122	rif	rif	PROPN
eurjchem-2615	300	123	:	:	PUNCT
eurjchem-2615	300	124	rifampicin	rifampicin	VERB
eurjchem-2615	300	125	;	;	PUNCT
eurjchem-2615	300	126	ic90	ic90	PROPN
eurjchem-2615	300	127	:	:	PUNCT
eurjchem-2615	300	128	90	90	NUM
eurjchem-2615	300	129	%	%	NOUN
eurjchem-2615	300	130	inhibitory	inhibitory	ADJ
eurjchem-2615	300	131	concentration	concentration	NOUN
eurjchem-2615	300	132	;	;	PUNCT
eurjchem-2615	300	133	katg	katg	PROPN
eurjchem-2615	300	134	:	:	PUNCT
eurjchem-2615	300	135	catalase	catalase	NOUN
eurjchem-2615	300	136	-	-	PUNCT
eurjchem-2615	300	137	peroxidase	peroxidase	NOUN
eurjchem-2615	300	138	.	.	PUNCT
eurjchem-2615	301	1	credit	credit	NOUN
eurjchem-2615	301	2	authorship	authorship	NOUN
eurjchem-2615	301	3	contribution	contribution	NOUN
eurjchem-2615	301	4	statement	statement	NOUN
eurjchem-2615	301	5	conceptualization	conceptualization	NOUN
eurjchem-2615	301	6	:	:	PUNCT
eurjchem-2615	301	7	paolo	paolo	PROPN
eurjchem-2615	301	8	coghi	coghi	PROPN
eurjchem-2615	301	9	;	;	PUNCT
eurjchem-2615	301	10	methodology	methodology	NOUN
eurjchem-2615	301	11	:	:	PUNCT
eurjchem-2615	301	12	ren	ren	PROPN
eurjchem-2615	301	13	zimo	zimo	PROPN
eurjchem-2615	301	14	;	;	PUNCT
eurjchem-2615	301	15	software	software	NOUN
eurjchem-2615	301	16	:	:	PUNCT
eurjchem-2615	301	17	ren	ren	PROPN
eurjchem-2615	301	18	zimo	zimo	PROPN
eurjchem-2615	301	19	;	;	PUNCT
eurjchem-2615	301	20	validation	validation	NOUN
eurjchem-2615	301	21	:	:	PUNCT
eurjchem-2615	302	1	ren	ren	PROPN
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eurjchem-2615	302	7	ren	ren	PROPN
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eurjchem-2615	302	9	;	;	PUNCT
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eurjchem-2615	302	12	ren	ren	PROPN
eurjchem-2615	302	13	zimo	zimo	PROPN
eurjchem-2615	302	14	;	;	PUNCT
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eurjchem-2615	302	18	ren	ren	PROPN
eurjchem-2615	302	19	zimo	zimo	PROPN
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eurjchem-2615	302	40	:	:	PUNCT
eurjchem-2615	302	41	paolo	paolo	PROPN
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eurjchem-2615	302	46	:	:	PUNCT
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eurjchem-2615	302	51	:	:	PUNCT
eurjchem-2615	302	52	paolo	paolo	PROPN
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eurjchem-2615	302	54	;	;	PUNCT
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eurjchem-2615	302	57	:	:	PUNCT
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eurjchem-2615	303	4	ren	ren	PROPN
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eurjchem-2615	306	3	coghi	coghi	PROPN
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eurjchem-2615	306	8	1	1	NUM
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eurjchem-2615	307	5	;	;	PUNCT
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eurjchem-2615	307	9	;	;	PUNCT
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eurjchem-2615	307	13	;	;	PUNCT
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eurjchem-2615	310	7	1	1	NUM
eurjchem-2615	310	8	)	)	PUNCT
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eurjchem-2615	312	2	2	2	NUM
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eurjchem-2615	316	2	3	3	NUM
eurjchem-2615	316	3	]	]	PUNCT
eurjchem-2615	316	4	.	.	PUNCT
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eurjchem-2615	318	1	lancet	lancet	PROPN
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eurjchem-2615	319	2	4	4	NUM
eurjchem-2615	319	3	]	]	PUNCT
eurjchem-2615	319	4	.	.	PUNCT
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eurjchem-2615	319	59	;	;	PUNCT
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eurjchem-2615	319	132	;	;	PUNCT
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eurjchem-2615	319	145	d.	d.	PROPN
eurjchem-2615	319	146	;	;	PUNCT
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eurjchem-2615	319	167	e.	e.	PROPN
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eurjchem-2615	319	208	-	-	PUNCT
eurjchem-2615	319	209	resistant	resistant	ADJ
eurjchem-2615	319	210	,	,	PUNCT
eurjchem-2615	319	211	and	and	CCONJ
eurjchem-2615	319	212	incurable	incurable	ADJ
eurjchem-2615	319	213	tuberculosis	tuberculosis	NOUN
eurjchem-2615	319	214	.	.	PUNCT
eurjchem-2615	320	1	lancet	lancet	PROPN
eurjchem-2615	320	2	respir	respir	PROPN
eurjchem-2615	320	3	.	.	PUNCT
eurjchem-2615	321	1	med	med	PROPN
eurjchem-2615	321	2	.	.	PROPN
eurjchem-2615	322	1	2017	2017	NUM
eurjchem-2615	322	2	,	,	PUNCT
eurjchem-2615	322	3	5	5	NUM
eurjchem-2615	322	4	(	(	PUNCT
eurjchem-2615	322	5	4	4	NUM
eurjchem-2615	322	6	)	)	PUNCT
eurjchem-2615	322	7	,	,	PUNCT
eurjchem-2615	322	8	291–360	291–360	NUM
eurjchem-2615	322	9	.	.	PUNCT
eurjchem-2615	323	1	[	[	X
eurjchem-2615	323	2	5	5	NUM
eurjchem-2615	323	3	]	]	PUNCT
eurjchem-2615	323	4	.	.	PUNCT
eurjchem-2615	323	5	falzon	falzon	NOUN
eurjchem-2615	323	6	,	,	PUNCT
eurjchem-2615	323	7	d.	d.	PROPN
eurjchem-2615	323	8	;	;	PUNCT
eurjchem-2615	323	9	jaramillo	jaramillo	PROPN
eurjchem-2615	323	10	,	,	PUNCT
eurjchem-2615	323	11	e.	e.	PROPN
eurjchem-2615	323	12	;	;	PUNCT
eurjchem-2615	323	13	schünemann	schünemann	PROPN
eurjchem-2615	323	14	,	,	PUNCT
eurjchem-2615	323	15	h.	h.	PROPN
eurjchem-2615	323	16	;	;	PUNCT
eurjchem-2615	323	17	arentz	arentz	PROPN
eurjchem-2615	323	18	,	,	PUNCT
eurjchem-2615	323	19	m.	m.	NOUN
eurjchem-2615	323	20	;	;	PUNCT
eurjchem-2615	323	21	bauer	bauer	PROPN
eurjchem-2615	323	22	,	,	PUNCT
eurjchem-2615	323	23	m.	m.	NOUN
eurjchem-2615	323	24	;	;	PUNCT
eurjchem-2615	323	25	bayona	bayona	PROPN
eurjchem-2615	323	26	,	,	PUNCT
eurjchem-2615	323	27	j.	j.	PROPN
eurjchem-2615	323	28	;	;	PUNCT
eurjchem-2615	323	29	blanc	blanc	PROPN
eurjchem-2615	323	30	,	,	PUNCT
eurjchem-2615	323	31	l.	l.	PROPN
eurjchem-2615	323	32	;	;	PUNCT
eurjchem-2615	323	33	caminero	caminero	NOUN
eurjchem-2615	323	34	,	,	PUNCT
eurjchem-2615	323	35	j.	j.	PROPN
eurjchem-2615	323	36	;	;	PUNCT
eurjchem-2615	323	37	daley	daley	PROPN
eurjchem-2615	323	38	,	,	PUNCT
eurjchem-2615	323	39	c.	c.	PROPN
eurjchem-2615	323	40	;	;	PUNCT
eurjchem-2615	323	41	duncombe	duncombe	NOUN
eurjchem-2615	323	42	,	,	PUNCT
eurjchem-2615	323	43	c.	c.	PROPN
eurjchem-2615	323	44	;	;	PUNCT
eurjchem-2615	323	45	fitzpatrick	fitzpatrick	PROPN
eurjchem-2615	323	46	,	,	PUNCT
eurjchem-2615	323	47	c.	c.	PROPN
eurjchem-2615	323	48	;	;	PUNCT
eurjchem-2615	323	49	gebhard	gebhard	NOUN
eurjchem-2615	323	50	,	,	PUNCT
eurjchem-2615	323	51	a.	a.	NOUN
eurjchem-2615	323	52	;	;	PUNCT
eurjchem-2615	323	53	getahun	getahun	PROPN
eurjchem-2615	323	54	,	,	PUNCT
eurjchem-2615	323	55	h.	h.	PROPN
eurjchem-2615	323	56	;	;	PUNCT
eurjchem-2615	323	57	henkens	henken	NOUN
eurjchem-2615	323	58	,	,	PUNCT
eurjchem-2615	323	59	m.	m.	NOUN
eurjchem-2615	323	60	;	;	PUNCT
eurjchem-2615	323	61	holtz	holtz	NOUN
eurjchem-2615	323	62	,	,	PUNCT
eurjchem-2615	323	63	t.	t.	PROPN
eurjchem-2615	323	64	;	;	PUNCT
eurjchem-2615	323	65	keravec	keravec	PROPN
eurjchem-2615	323	66	,	,	PUNCT
eurjchem-2615	323	67	j.	j.	PROPN
eurjchem-2615	323	68	;	;	PUNCT
eurjchem-2615	323	69	keshavjee	keshavjee	PROPN
eurjchem-2615	323	70	,	,	PUNCT
eurjchem-2615	323	71	s.	s.	PROPN
eurjchem-2615	323	72	;	;	PUNCT
eurjchem-2615	323	73	khan	khan	PROPN
eurjchem-2615	323	74	,	,	PUNCT
eurjchem-2615	323	75	a.	a.	NOUN
eurjchem-2615	323	76	;	;	PUNCT
eurjchem-2615	323	77	kulier	kulier	PROPN
eurjchem-2615	323	78	,	,	PUNCT
eurjchem-2615	323	79	r.	r.	PROPN
eurjchem-2615	323	80	;	;	PUNCT
eurjchem-2615	323	81	leimane	leimane	NOUN
eurjchem-2615	323	82	,	,	PUNCT
eurjchem-2615	323	83	v.	v.	ADV
eurjchem-2615	323	84	;	;	PUNCT
eurjchem-2615	323	85	lienhardt	lienhardt	ADJ
eurjchem-2615	323	86	,	,	PUNCT
eurjchem-2615	323	87	c.	c.	PROPN
eurjchem-2615	323	88	;	;	PUNCT
eurjchem-2615	323	89	lu	lu	PROPN
eurjchem-2615	323	90	,	,	PUNCT
eurjchem-2615	323	91	c.	c.	PROPN
eurjchem-2615	323	92	;	;	PUNCT
eurjchem-2615	323	93	mariandyshev	mariandyshev	PROPN
eurjchem-2615	323	94	,	,	PUNCT
eurjchem-2615	323	95	a.	a.	PROPN
eurjchem-2615	323	96	;	;	PUNCT
eurjchem-2615	323	97	migliori	migliori	PROPN
eurjchem-2615	323	98	,	,	PUNCT
eurjchem-2615	323	99	g.	g.	PROPN
eurjchem-2615	323	100	;	;	PUNCT
eurjchem-2615	323	101	mirzayev	mirzayev	PROPN
eurjchem-2615	323	102	,	,	PUNCT
eurjchem-2615	323	103	f.	f.	PROPN
eurjchem-2615	323	104	;	;	PUNCT
eurjchem-2615	323	105	mitnick	mitnick	PROPN
eurjchem-2615	323	106	,	,	PUNCT
eurjchem-2615	323	107	c.	c.	PROPN
eurjchem-2615	323	108	;	;	PUNCT
eurjchem-2615	323	109	nunn	nunn	PROPN
eurjchem-2615	323	110	,	,	PUNCT
eurjchem-2615	323	111	p.	p.	PROPN
eurjchem-2615	323	112	;	;	PUNCT
eurjchem-2615	323	113	nwagboniwe	nwagboniwe	NOUN
eurjchem-2615	323	114	,	,	PUNCT
eurjchem-2615	323	115	g.	g.	PROPN
eurjchem-2615	323	116	;	;	PUNCT
eurjchem-2615	323	117	oxlade	oxlade	NOUN
eurjchem-2615	323	118	,	,	PUNCT
eurjchem-2615	323	119	o.	o.	PROPN
eurjchem-2615	323	120	;	;	PUNCT
eurjchem-2615	323	121	palmero	palmero	PROPN
eurjchem-2615	323	122	,	,	PUNCT
eurjchem-2615	323	123	d.	d.	PROPN
eurjchem-2615	323	124	;	;	PUNCT
eurjchem-2615	323	125	pavlinac	pavlinac	ADJ
eurjchem-2615	323	126	,	,	PUNCT
eurjchem-2615	323	127	p.	p.	NOUN
eurjchem-2615	323	128	;	;	PUNCT
eurjchem-2615	323	129	quelapio	quelapio	PROPN
eurjchem-2615	323	130	,	,	PUNCT
eurjchem-2615	323	131	m.	m.	NOUN
eurjchem-2615	323	132	;	;	PUNCT
eurjchem-2615	323	133	raviglione	raviglione	NOUN
eurjchem-2615	323	134	,	,	PUNCT
eurjchem-2615	323	135	m.	m.	NOUN
eurjchem-2615	323	136	;	;	PUNCT
eurjchem-2615	323	137	rich	rich	ADJ
eurjchem-2615	323	138	,	,	PUNCT
eurjchem-2615	323	139	m.	m.	NOUN
eurjchem-2615	323	140	;	;	PUNCT
eurjchem-2615	323	141	royce	royce	PROPN
eurjchem-2615	323	142	,	,	PUNCT
eurjchem-2615	323	143	s.	s.	PROPN
eurjchem-2615	323	144	;	;	PUNCT
eurjchem-2615	323	145	rüsch	rüsch	NOUN
eurjchem-2615	323	146	-	-	PUNCT
eurjchem-2615	323	147	gerdes	gerde	NOUN
eurjchem-2615	323	148	,	,	PUNCT
eurjchem-2615	323	149	s.	s.	PROPN
eurjchem-2615	323	150	;	;	PUNCT
eurjchem-2615	323	151	salakaia	salakaia	PROPN
eurjchem-2615	323	152	,	,	PUNCT
eurjchem-2615	323	153	a.	a.	NOUN
eurjchem-2615	323	154	;	;	PUNCT
eurjchem-2615	323	155	sarin	sarin	NOUN
eurjchem-2615	323	156	,	,	PUNCT
eurjchem-2615	323	157	r.	r.	PROPN
eurjchem-2615	323	158	;	;	PUNCT
eurjchem-2615	323	159	sculier	sculier	PROPN
eurjchem-2615	323	160	,	,	PUNCT
eurjchem-2615	323	161	d.	d.	PROPN
eurjchem-2615	323	162	;	;	PUNCT
eurjchem-2615	323	163	varaine	varaine	NOUN
eurjchem-2615	323	164	,	,	PUNCT
eurjchem-2615	323	165	f.	f.	PROPN
eurjchem-2615	323	166	;	;	PUNCT
eurjchem-2615	323	167	vitoria	vitoria	PROPN
eurjchem-2615	323	168	,	,	PUNCT
eurjchem-2615	323	169	m.	m.	NOUN
eurjchem-2615	323	170	;	;	PUNCT
eurjchem-2615	323	171	walson	walson	NOUN
eurjchem-2615	323	172	,	,	PUNCT
eurjchem-2615	323	173	j.	j.	PROPN
eurjchem-2615	323	174	;	;	PUNCT
eurjchem-2615	323	175	wares	ware	NOUN
eurjchem-2615	323	176	,	,	PUNCT
eurjchem-2615	323	177	f.	f.	PROPN
eurjchem-2615	323	178	;	;	PUNCT
eurjchem-2615	323	179	weyer	weyer	PROPN
eurjchem-2615	323	180	,	,	PUNCT
eurjchem-2615	323	181	k.	k.	PROPN
eurjchem-2615	323	182	;	;	PUNCT
eurjchem-2615	323	183	white	white	PROPN
eurjchem-2615	323	184	,	,	PUNCT
eurjchem-2615	323	185	r.	r.	PROPN
eurjchem-2615	323	186	;	;	PUNCT
eurjchem-2615	323	187	zignol	zignol	NOUN
eurjchem-2615	323	188	,	,	PUNCT
eurjchem-2615	323	189	m.	m.	NOUN
eurjchem-2615	323	190	who	who	PRON
eurjchem-2615	323	191	guidelines	guideline	VERB
eurjchem-2615	323	192	for	for	ADP
eurjchem-2615	323	193	the	the	DET
eurjchem-2615	323	194	programmatic	programmatic	ADJ
eurjchem-2615	323	195	management	management	NOUN
eurjchem-2615	323	196	of	of	ADP
eurjchem-2615	323	197	drug	drug	NOUN
eurjchem-2615	323	198	-	-	PUNCT
eurjchem-2615	323	199	resistant	resistant	ADJ
eurjchem-2615	323	200	tuberculosis	tuberculosis	NOUN
eurjchem-2615	323	201	:	:	PUNCT
eurjchem-2615	323	202	2011	2011	NUM
eurjchem-2615	323	203	update	update	NOUN
eurjchem-2615	323	204	.	.	PUNCT
eurjchem-2615	324	1	eur	eur	PROPN
eurjchem-2615	324	2	.	.	PUNCT
eurjchem-2615	324	3	respir	respir	PROPN
eurjchem-2615	324	4	.	.	PUNCT
eurjchem-2615	325	1	j.	j.	PROPN
eurjchem-2615	325	2	2011	2011	PROPN
eurjchem-2615	325	3	,	,	PUNCT
eurjchem-2615	325	4	38	38	NUM
eurjchem-2615	325	5	(	(	PUNCT
eurjchem-2615	325	6	3	3	NUM
eurjchem-2615	325	7	)	)	PUNCT
eurjchem-2615	325	8	,	,	PUNCT
eurjchem-2615	325	9	516–528	516–528	NUM
eurjchem-2615	325	10	.	.	PUNCT
eurjchem-2615	326	1	[	[	X
eurjchem-2615	326	2	6	6	NUM
eurjchem-2615	326	3	]	]	PUNCT
eurjchem-2615	326	4	.	.	PUNCT
eurjchem-2615	327	1	zumla	zumla	NOUN
eurjchem-2615	327	2	,	,	PUNCT
eurjchem-2615	327	3	a.	a.	NOUN
eurjchem-2615	327	4	i.	i.	PROPN
eurjchem-2615	327	5	;	;	PUNCT
eurjchem-2615	327	6	gillespie	gillespie	PROPN
eurjchem-2615	327	7	,	,	PUNCT
eurjchem-2615	327	8	s.	s.	PROPN
eurjchem-2615	327	9	h.	h.	PROPN
eurjchem-2615	327	10	;	;	PUNCT
eurjchem-2615	327	11	hoelscher	hoelscher	ADV
eurjchem-2615	327	12	,	,	PUNCT
eurjchem-2615	327	13	m.	m.	NOUN
eurjchem-2615	327	14	;	;	PUNCT
eurjchem-2615	327	15	philips	philip	NOUN
eurjchem-2615	327	16	,	,	PUNCT
eurjchem-2615	327	17	p.	p.	NOUN
eurjchem-2615	327	18	p.	p.	PROPN
eurjchem-2615	327	19	;	;	PUNCT
eurjchem-2615	327	20	cole	cole	PROPN
eurjchem-2615	327	21	,	,	PUNCT
eurjchem-2615	327	22	s.	s.	PROPN
eurjchem-2615	327	23	t.	t.	PROPN
eurjchem-2615	327	24	;	;	PUNCT
eurjchem-2615	327	25	abubakar	abubakar	PROPN
eurjchem-2615	327	26	,	,	PUNCT
eurjchem-2615	327	27	i.	i.	PROPN
eurjchem-2615	327	28	;	;	PUNCT
eurjchem-2615	327	29	mchugh	mchugh	PROPN
eurjchem-2615	327	30	,	,	PUNCT
eurjchem-2615	327	31	t.	t.	PROPN
eurjchem-2615	327	32	d.	d.	PROPN
eurjchem-2615	327	33	;	;	PUNCT
eurjchem-2615	327	34	schito	schito	PROPN
eurjchem-2615	327	35	,	,	PUNCT
eurjchem-2615	327	36	m.	m.	NOUN
eurjchem-2615	327	37	;	;	PUNCT
eurjchem-2615	327	38	maeurer	maeurer	NOUN
eurjchem-2615	327	39	,	,	PUNCT
eurjchem-2615	327	40	m.	m.	NOUN
eurjchem-2615	327	41	;	;	PUNCT
eurjchem-2615	327	42	nunn	nunn	PROPN
eurjchem-2615	327	43	,	,	PUNCT
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eurjchem-2615	327	45	j.	j.	PROPN
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eurjchem-2615	327	48	drugs	drug	NOUN
eurjchem-2615	327	49	,	,	PUNCT
eurjchem-2615	327	50	regimens	regimen	NOUN
eurjchem-2615	327	51	,	,	PUNCT
eurjchem-2615	327	52	and	and	CCONJ
eurjchem-2615	327	53	adjunct	adjunct	ADJ
eurjchem-2615	327	54	therapies	therapy	NOUN
eurjchem-2615	327	55	:	:	PUNCT
eurjchem-2615	327	56	needs	need	NOUN
eurjchem-2615	327	57	,	,	PUNCT
eurjchem-2615	327	58	advances	advance	NOUN
eurjchem-2615	327	59	,	,	PUNCT
eurjchem-2615	327	60	and	and	CCONJ
eurjchem-2615	327	61	future	future	ADJ
eurjchem-2615	327	62	prospects	prospect	NOUN
eurjchem-2615	327	63	.	.	PUNCT
eurjchem-2615	328	1	lancet	lancet	NOUN
eurjchem-2615	328	2	infect	infect	PROPN
eurjchem-2615	328	3	.	.	PUNCT
eurjchem-2615	329	1	dis	dis	PROPN
eurjchem-2615	329	2	.	.	PROPN
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eurjchem-2615	330	2	,	,	PUNCT
eurjchem-2615	330	3	14	14	NUM
eurjchem-2615	330	4	(	(	PUNCT
eurjchem-2615	330	5	4	4	NUM
eurjchem-2615	330	6	)	)	PUNCT
eurjchem-2615	330	7	,	,	PUNCT
eurjchem-2615	330	8	327	327	NUM
eurjchem-2615	330	9	–	–	PUNCT
eurjchem-2615	330	10	340	340	NUM
eurjchem-2615	330	11	.	.	PUNCT
eurjchem-2615	331	1	[	[	X
eurjchem-2615	331	2	7	7	NUM
eurjchem-2615	331	3	]	]	PUNCT
eurjchem-2615	331	4	.	.	PUNCT
eurjchem-2615	332	1	getahun	getahun	PROPN
eurjchem-2615	332	2	,	,	PUNCT
eurjchem-2615	332	3	h.	h.	PROPN
eurjchem-2615	332	4	;	;	PUNCT
eurjchem-2615	332	5	matteelli	matteelli	PROPN
eurjchem-2615	332	6	,	,	PUNCT
eurjchem-2615	332	7	a.	a.	NOUN
eurjchem-2615	332	8	;	;	PUNCT
eurjchem-2615	332	9	chaisson	chaisson	PROPN
eurjchem-2615	332	10	,	,	PUNCT
eurjchem-2615	332	11	r.	r.	PROPN
eurjchem-2615	332	12	e.	e.	PROPN
eurjchem-2615	332	13	;	;	PUNCT
eurjchem-2615	332	14	raviglione	raviglione	VERB
eurjchem-2615	332	15	,	,	PUNCT
eurjchem-2615	332	16	m.	m.	NOUN
eurjchem-2615	332	17	latentmycobacterium	latentmycobacterium	NOUN
eurjchem-2615	332	18	tuberculosisinfection	tuberculosisinfection	NOUN
eurjchem-2615	332	19	.	.	PUNCT
eurjchem-2615	333	1	n.	n.	PROPN
eurjchem-2615	333	2	engl	engl	PROPN
eurjchem-2615	333	3	.	.	PUNCT
eurjchem-2615	334	1	j.	j.	PROPN
eurjchem-2615	334	2	med	med	PROPN
eurjchem-2615	334	3	.	.	PROPN
eurjchem-2615	335	1	2015	2015	NUM
eurjchem-2615	335	2	,	,	PUNCT
eurjchem-2615	335	3	372	372	NUM
eurjchem-2615	335	4	(	(	PUNCT
eurjchem-2615	335	5	22	22	NUM
eurjchem-2615	335	6	)	)	PUNCT
eurjchem-2615	335	7	,	,	PUNCT
eurjchem-2615	335	8	2127–2135	2127–2135	NUM
eurjchem-2615	335	9	.	.	PUNCT
eurjchem-2615	336	1	[	[	X
eurjchem-2615	336	2	8	8	NUM
eurjchem-2615	336	3	]	]	PUNCT
eurjchem-2615	336	4	.	.	PUNCT
eurjchem-2615	337	1	nathavitharana	nathavitharana	PROPN
eurjchem-2615	337	2	,	,	PUNCT
eurjchem-2615	337	3	r.	r.	PROPN
eurjchem-2615	337	4	r.	r.	PROPN
eurjchem-2615	337	5	;	;	PUNCT
eurjchem-2615	337	6	friedland	friedland	PROPN
eurjchem-2615	337	7	,	,	PUNCT
eurjchem-2615	337	8	j.	j.	PROPN
eurjchem-2615	337	9	s.	s.	PROPN
eurjchem-2615	338	1	a	a	DET
eurjchem-2615	338	2	tale	tale	NOUN
eurjchem-2615	338	3	of	of	ADP
eurjchem-2615	338	4	two	two	NUM
eurjchem-2615	338	5	global	global	ADJ
eurjchem-2615	338	6	emergencies	emergency	NOUN
eurjchem-2615	338	7	:	:	PUNCT
eurjchem-2615	338	8	tuberculosis	tuberculosis	NOUN
eurjchem-2615	338	9	control	control	NOUN
eurjchem-2615	338	10	efforts	effort	NOUN
eurjchem-2615	338	11	can	can	AUX
eurjchem-2615	338	12	learn	learn	VERB
eurjchem-2615	338	13	from	from	ADP
eurjchem-2615	338	14	the	the	DET
eurjchem-2615	338	15	ebola	ebola	PROPN
eurjchem-2615	338	16	outbreak	outbreak	NOUN
eurjchem-2615	338	17	.	.	PUNCT
eurjchem-2615	339	1	eur	eur	PROPN
eurjchem-2615	339	2	.	.	PUNCT
eurjchem-2615	339	3	respir	respir	PROPN
eurjchem-2615	339	4	.	.	PUNCT
eurjchem-2615	340	1	j.	j.	PROPN
eurjchem-2615	340	2	2015	2015	NUM
eurjchem-2615	340	3	,	,	PUNCT
eurjchem-2615	340	4	46	46	NUM
eurjchem-2615	340	5	(	(	PUNCT
eurjchem-2615	340	6	2	2	NUM
eurjchem-2615	340	7	)	)	PUNCT
eurjchem-2615	340	8	,	,	PUNCT
eurjchem-2615	340	9	293–296	293–296	NUM
eurjchem-2615	340	10	.	.	PUNCT
eurjchem-2615	341	1	[	[	X
eurjchem-2615	341	2	9	9	NUM
eurjchem-2615	341	3	]	]	PUNCT
eurjchem-2615	341	4	.	.	PUNCT
eurjchem-2615	342	1	zhao	zhao	PROPN
eurjchem-2615	342	2	,	,	PUNCT
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eurjchem-2615	342	4	;	;	PUNCT
eurjchem-2615	342	5	li	li	PROPN
eurjchem-2615	342	6	,	,	PUNCT
eurjchem-2615	342	7	z.	z.	PROPN
eurjchem-2615	342	8	;	;	PUNCT
eurjchem-2615	342	9	zhang	zhang	PROPN
eurjchem-2615	342	10	,	,	PUNCT
eurjchem-2615	342	11	r.	r.	PROPN
eurjchem-2615	342	12	;	;	PUNCT
eurjchem-2615	342	13	zhou	zhou	PROPN
eurjchem-2615	342	14	,	,	PUNCT
eurjchem-2615	342	15	l.	l.	PROPN
eurjchem-2615	342	16	;	;	PUNCT
eurjchem-2615	342	17	zhao	zhao	PROPN
eurjchem-2615	342	18	,	,	PUNCT
eurjchem-2615	342	19	h.	h.	PROPN
eurjchem-2615	342	20	;	;	PUNCT
eurjchem-2615	342	21	jiang	jiang	PROPN
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eurjchem-2615	342	23	h.	h.	PROPN
eurjchem-2615	342	24	tetrazine	tetrazine	PROPN
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eurjchem-2615	342	26	chemistry	chemistry	NOUN
eurjchem-2615	342	27	derived	derive	VERB
eurjchem-2615	342	28	in	in	ADP
eurjchem-2615	342	29	vivo	vivo	ADJ
eurjchem-2615	342	30	imaging	imaging	NOUN
eurjchem-2615	342	31	.	.	PUNCT
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eurjchem-2615	344	2	.	.	PUNCT
eurjchem-2615	345	1	biosci	biosci	PROPN
eurjchem-2615	345	2	.	.	PUNCT
eurjchem-2615	346	1	2022	2022	NUM
eurjchem-2615	346	2	,	,	PUNCT
eurjchem-2615	346	3	9	9	NUM
eurjchem-2615	346	4	,	,	PUNCT
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eurjchem-2615	348	1	[	[	X
eurjchem-2615	348	2	10	10	NUM
eurjchem-2615	348	3	]	]	PUNCT
eurjchem-2615	348	4	.	.	PUNCT
eurjchem-2615	349	1	kuan	kuan	PROPN
eurjchem-2615	349	2	,	,	PUNCT
eurjchem-2615	349	3	h.	h.	PROPN
eurjchem-2615	349	4	;	;	PUNCT
eurjchem-2615	349	5	xie	xie	PROPN
eurjchem-2615	349	6	,	,	PUNCT
eurjchem-2615	349	7	y.	y.	PROPN
eurjchem-2615	349	8	;	;	PUNCT
eurjchem-2615	349	9	guo	guo	PROPN
eurjchem-2615	349	10	,	,	PUNCT
eurjchem-2615	349	11	y.	y.	PROPN
eurjchem-2615	349	12	;	;	PUNCT
eurjchem-2615	349	13	gianoncelli	gianoncelli	PROPN
eurjchem-2615	349	14	,	,	PUNCT
eurjchem-2615	349	15	a.	a.	NOUN
eurjchem-2615	349	16	;	;	PUNCT
eurjchem-2615	349	17	ribaudo	ribaudo	NOUN
eurjchem-2615	349	18	,	,	PUNCT
eurjchem-2615	349	19	g.	g.	PROPN
eurjchem-2615	349	20	;	;	PUNCT
eurjchem-2615	349	21	coghi	coghi	PROPN
eurjchem-2615	349	22	,	,	PUNCT
eurjchem-2615	349	23	p.	p.	NOUN
eurjchem-2615	349	24	(	(	PUNCT
eurjchem-2615	349	25	2r	2r	NUM
eurjchem-2615	349	26	,	,	PUNCT
eurjchem-2615	349	27	4s	4s	NUM
eurjchem-2615	349	28	,	,	PUNCT
eurjchem-2615	349	29	5s	5s	NUM
eurjchem-2615	349	30	)	)	PUNCT
eurjchem-2615	349	31	1-(4-(4-(((7	1-(4-(4-(((7	NUM
eurjchem-2615	349	32	-	-	PUNCT
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eurjchem-2615	349	34	-	-	PUNCT
eurjchem-2615	349	35	yl)amino)methyl)-1h-1,2,3	yl)amino)methyl)-1h-1,2,3	ADJ
eurjchem-2615	349	36	-	-	PUNCT
eurjchem-2615	349	37	triazol	triazol	ADJ
eurjchem-2615	349	38	-1	-1	ADJ
eurjchem-2615	349	39	-	-	PUNCT
eurjchem-2615	349	40	yl)-5-(hydroxymethyl)tetrahydrofuran-2	yl)-5-(hydroxymethyl)tetrahydrofuran-2	NOUN
eurjchem-2615	349	41	-	-	PUNCT
eurjchem-2615	349	42	yl)-5	yl)-5	NOUN
eurjchem-2615	349	43	-	-	PUNCT
eurjchem-2615	349	44	methylpyrimidine2,4(1h,3h)-dione	methylpyrimidine2,4(1h,3h)-dione	PROPN
eurjchem-2615	349	45	.	.	PUNCT
eurjchem-2615	349	46	molbank	molbank	PROPN
eurjchem-2615	349	47	2023	2023	NUM
eurjchem-2615	349	48	,	,	PUNCT
eurjchem-2615	349	49	2023	2023	NUM
eurjchem-2615	349	50	(	(	PUNCT
eurjchem-2615	349	51	3	3	NUM
eurjchem-2615	349	52	)	)	PUNCT
eurjchem-2615	349	53	,	,	PUNCT
eurjchem-2615	349	54	m1681	m1681	X
eurjchem-2615	349	55	.	.	PUNCT
eurjchem-2615	350	1	[	[	X
eurjchem-2615	350	2	11	11	NUM
eurjchem-2615	350	3	]	]	PUNCT
eurjchem-2615	350	4	.	.	PUNCT
eurjchem-2615	351	1	fai	fai	PROPN
eurjchem-2615	351	2	,	,	PUNCT
eurjchem-2615	351	3	l.	l.	PROPN
eurjchem-2615	351	4	k.	k.	PROPN
eurjchem-2615	351	5	;	;	PUNCT
eurjchem-2615	351	6	anyanwu	anyanwu	PROPN
eurjchem-2615	351	7	,	,	PUNCT
eurjchem-2615	351	8	m.	m.	NOUN
eurjchem-2615	351	9	;	;	PUNCT
eurjchem-2615	351	10	ai	ai	VERB
eurjchem-2615	351	11	,	,	PUNCT
eurjchem-2615	351	12	j.	j.	PROPN
eurjchem-2615	351	13	;	;	PUNCT
eurjchem-2615	351	14	xie	xie	PROPN
eurjchem-2615	351	15	,	,	PUNCT
eurjchem-2615	351	16	y.	y.	PROPN
eurjchem-2615	351	17	;	;	PUNCT
eurjchem-2615	351	18	gianoncelli	gianoncelli	PROPN
eurjchem-2615	351	19	,	,	PUNCT
eurjchem-2615	351	20	a.	a.	NOUN
eurjchem-2615	351	21	;	;	PUNCT
eurjchem-2615	351	22	ribaudo	ribaudo	NOUN
eurjchem-2615	351	23	,	,	PUNCT
eurjchem-2615	351	24	g.	g.	PROPN
eurjchem-2615	351	25	;	;	PUNCT
eurjchem-2615	351	26	coghi	coghi	PROPN
eurjchem-2615	351	27	,	,	PUNCT
eurjchem-2615	351	28	p.	p.	NOUN
eurjchem-2615	352	1	4-(4-(((1h	4-(4-(((1h	PROPN
eurjchem-2615	353	1	-	-	PUNCT
eurjchem-2615	353	2	benzo[d][1,2,3]triazol-1	benzo[d][1,2,3]triazol-1	NUM
eurjchem-2615	353	3	-	-	PUNCT
eurjchem-2615	353	4	yl)oxy)methyl)-1h-1,2,3	yl)oxy)methyl)-1h-1,2,3	NOUN
eurjchem-2615	354	1	-	-	NOUN
eurjchem-2615	354	2	triaz	triaz	NOUN
eurjchem-2615	354	3	ol-1	ol-1	NUM
eurjchem-2615	354	4	-	-	PUNCT
eurjchem-2615	354	5	yl)-7	yl)-7	NOUN
eurjchem-2615	354	6	-	-	PUNCT
eurjchem-2615	354	7	chloroquinoline	chloroquinoline	NOUN
eurjchem-2615	354	8	.	.	PUNCT
eurjchem-2615	355	1	molbank	molbank	PROPN
eurjchem-2615	355	2	2022	2022	NUM
eurjchem-2615	355	3	,	,	PUNCT
eurjchem-2615	355	4	2022	2022	NUM
eurjchem-2615	355	5	(	(	PUNCT
eurjchem-2615	355	6	3	3	NUM
eurjchem-2615	355	7	)	)	PUNCT
eurjchem-2615	355	8	,	,	PUNCT
eurjchem-2615	355	9	m1404	m1404	PROPN
eurjchem-2615	355	10	.	.	PUNCT
eurjchem-2615	356	1	[	[	X
eurjchem-2615	356	2	12	12	NUM
eurjchem-2615	356	3	]	]	PUNCT
eurjchem-2615	356	4	.	.	PUNCT
eurjchem-2615	357	1	jiang	jiang	PROPN
eurjchem-2615	357	2	,	,	PUNCT
eurjchem-2615	357	3	x.	x.	PROPN
eurjchem-2615	357	4	;	;	PUNCT
eurjchem-2615	357	5	hao	hao	PROPN
eurjchem-2615	357	6	,	,	PUNCT
eurjchem-2615	357	7	x.	x.	PROPN
eurjchem-2615	357	8	;	;	PUNCT
eurjchem-2615	357	9	jing	jing	PROPN
eurjchem-2615	357	10	,	,	PUNCT
eurjchem-2615	357	11	l.	l.	PROPN
eurjchem-2615	357	12	;	;	PUNCT
eurjchem-2615	357	13	wu	wu	PROPN
eurjchem-2615	357	14	,	,	PUNCT
eurjchem-2615	357	15	g.	g.	PROPN
eurjchem-2615	357	16	;	;	PUNCT
eurjchem-2615	357	17	kang	kang	PROPN
eurjchem-2615	357	18	,	,	PUNCT
eurjchem-2615	357	19	d.	d.	PROPN
eurjchem-2615	357	20	;	;	PUNCT
eurjchem-2615	357	21	liu	liu	PROPN
eurjchem-2615	357	22	,	,	PUNCT
eurjchem-2615	357	23	x.	x.	PROPN
eurjchem-2615	357	24	;	;	PUNCT
eurjchem-2615	357	25	zhan	zhan	NUM
eurjchem-2615	357	26	,	,	PUNCT
eurjchem-2615	357	27	p.	p.	NOUN
eurjchem-2615	357	28	recent	recent	ADJ
eurjchem-2615	357	29	applications	application	NOUN
eurjchem-2615	357	30	of	of	ADP
eurjchem-2615	357	31	click	click	VERB
eurjchem-2615	357	32	chemistry	chemistry	NOUN
eurjchem-2615	357	33	in	in	ADP
eurjchem-2615	357	34	drug	drug	NOUN
eurjchem-2615	357	35	discovery	discovery	NOUN
eurjchem-2615	357	36	.	.	PUNCT
eurjchem-2615	358	1	expert	expert	NOUN
eurjchem-2615	358	2	opin	opin	NOUN
eurjchem-2615	358	3	.	.	PUNCT
eurjchem-2615	359	1	drug	drug	NOUN
eurjchem-2615	359	2	discov	discov	NOUN
eurjchem-2615	359	3	.	.	PUNCT
eurjchem-2615	360	1	2019	2019	NUM
eurjchem-2615	360	2	,	,	PUNCT
eurjchem-2615	360	3	14	14	NUM
eurjchem-2615	360	4	(	(	PUNCT
eurjchem-2615	360	5	8)	8)	NUM
eurjchem-2615	360	6	,	,	PUNCT
eurjchem-2615	360	7	779–789	779–789	NUM
eurjchem-2615	360	8	.	.	PUNCT
eurjchem-2615	361	1	[	[	X
eurjchem-2615	361	2	13	13	NUM
eurjchem-2615	361	3	]	]	PUNCT
eurjchem-2615	361	4	.	.	PUNCT
eurjchem-2615	361	5	yun	yun	PROPN
eurjchem-2615	361	6	,	,	PUNCT
eurjchem-2615	361	7	x.	x.	PROPN
eurjchem-2615	361	8	;	;	PUNCT
eurjchem-2615	361	9	xie	xie	PROPN
eurjchem-2615	361	10	,	,	PUNCT
eurjchem-2615	361	11	y.	y.	PROPN
eurjchem-2615	361	12	;	;	PUNCT
eurjchem-2615	361	13	ng	ng	PROPN
eurjchem-2615	361	14	,	,	PUNCT
eurjchem-2615	361	15	j.	j.	PROPN
eurjchem-2615	361	16	p.	p.	PROPN
eurjchem-2615	361	17	;	;	PUNCT
eurjchem-2615	361	18	law	law	NOUN
eurjchem-2615	361	19	,	,	PUNCT
eurjchem-2615	361	20	b.	b.	PROPN
eurjchem-2615	361	21	y.	y.	PROPN
eurjchem-2615	361	22	;	;	PUNCT
eurjchem-2615	361	23	wong	wong	PROPN
eurjchem-2615	361	24	,	,	PUNCT
eurjchem-2615	361	25	v.	v.	PROPN
eurjchem-2615	361	26	k.	k.	PROPN
eurjchem-2615	361	27	;	;	PUNCT
eurjchem-2615	361	28	coghi	coghi	PROPN
eurjchem-2615	361	29	,	,	PUNCT
eurjchem-2615	361	30	p.	p.	NOUN
eurjchem-2615	361	31	2	2	NUM
eurjchem-2615	361	32	-	-	PUNCT
eurjchem-2615	361	33	bromo-3((1-(7	bromo-3((1-(7	NUM
eurjchem-2615	361	34	-	-	PUNCT
eurjchem-2615	361	35	chloroquinolin-4	chloroquinolin-4	NOUN
eurjchem-2615	361	36	-	-	NOUN
eurjchem-2615	361	37	yl)-1h-1,2,3	yl)-1h-1,2,3	NOUN
eurjchem-2615	361	38	-	-	PUNCT
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eurjchem-2615	361	40	-	-	PUNCT
eurjchem-2615	361	41	yl)-methoxy)-benz	yl)-methoxy)-benz	NOUN
eurjchem-2615	361	42	aldehyde	aldehyde	NOUN
eurjchem-2615	361	43	.	.	PUNCT
eurjchem-2615	362	1	molbank	molbank	PROPN
eurjchem-2615	362	2	2022	2022	NUM
eurjchem-2615	362	3	,	,	PUNCT
eurjchem-2615	362	4	2022	2022	NUM
eurjchem-2615	362	5	(	(	PUNCT
eurjchem-2615	362	6	1	1	NUM
eurjchem-2615	362	7	)	)	PUNCT
eurjchem-2615	362	8	,	,	PUNCT
eurjchem-2615	362	9	m1351	m1351	NOUN
eurjchem-2615	362	10	.	.	PUNCT
eurjchem-2615	363	1	[	[	X
eurjchem-2615	363	2	14	14	NUM
eurjchem-2615	363	3	]	]	SYM
eurjchem-2615	363	4	.	.	PUNCT
eurjchem-2615	364	1	ng	ng	PROPN
eurjchem-2615	364	2	,	,	PUNCT
eurjchem-2615	364	3	j.	j.	PROPN
eurjchem-2615	364	4	p.	p.	PROPN
eurjchem-2615	364	5	;	;	PUNCT
eurjchem-2615	364	6	xiao	xiao	PROPN
eurjchem-2615	364	7	yun	yun	PROPN
eurjchem-2615	364	8	,	,	PUNCT
eurjchem-2615	364	9	y.	y.	PROPN
eurjchem-2615	364	10	;	;	PUNCT
eurjchem-2615	364	11	adnan	adnan	PROPN
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eurjchem-2615	364	13	,	,	PUNCT
eurjchem-2615	364	14	a.	a.	NOUN
eurjchem-2615	364	15	;	;	PUNCT
eurjchem-2615	364	16	gianoncelli	gianoncelli	PROPN
eurjchem-2615	364	17	,	,	PUNCT
eurjchem-2615	364	18	a.	a.	NOUN
eurjchem-2615	364	19	;	;	PUNCT
eurjchem-2615	364	20	yuan	yuan	PROPN
eurjchem-2615	364	21	kwan	kwan	PROPN
eurjchem-2615	364	22	law	law	PROPN
eurjchem-2615	364	23	,	,	PUNCT
eurjchem-2615	364	24	b.	b.	PROPN
eurjchem-2615	364	25	;	;	PUNCT
eurjchem-2615	364	26	ribaudo	ribaudo	PROPN
eurjchem-2615	364	27	,	,	PUNCT
eurjchem-2615	364	28	g.	g.	PROPN
eurjchem-2615	364	29	;	;	PUNCT
eurjchem-2615	364	30	kam	kam	PROPN
eurjchem-2615	364	31	wai	wai	PROPN
eurjchem-2615	364	32	wong	wong	PROPN
eurjchem-2615	364	33	,	,	PUNCT
eurjchem-2615	364	34	v.	v.	PROPN
eurjchem-2615	364	35	;	;	PUNCT
eurjchem-2615	364	36	coghi	coghi	NOUN
eurjchem-2615	364	37	,	,	PUNCT
eurjchem-2615	364	38	p.	p.	NOUN
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eurjchem-2615	364	40	,	,	PUNCT
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eurjchem-2615	364	42	studies	study	NOUN
eurjchem-2615	364	43	and	and	CCONJ
eurjchem-2615	364	44	biological	biological	ADJ
eurjchem-2615	364	45	evaluation	evaluation	NOUN
eurjchem-2615	364	46	of	of	ADP
eurjchem-2615	364	47	1h-1,2,3	1h-1,2,3	NUM
eurjchem-2615	364	48	-	-	PUNCT
eurjchem-2615	364	49	triazole-7	triazole-7	NUM
eurjchem-2615	364	50	-	-	PUNCT
eurjchem-2615	364	51	chloroquinoline	chloroquinoline	ADJ
eurjchem-2615	364	52	derivatives	derivative	NOUN
eurjchem-2615	364	53	against	against	ADP
eurjchem-2615	364	54	sars	sar	NOUN
eurjchem-2615	364	55	-	-	PUNCT
eurjchem-2615	364	56	cov-2	cov-2	NOUN
eurjchem-2615	364	57	.	.	PUNCT
eurjchem-2615	364	58	bioorg	bioorg	PROPN
eurjchem-2615	364	59	.	.	PUNCT
eurjchem-2615	365	1	chem	chem	NOUN
eurjchem-2615	365	2	.	.	PUNCT
eurjchem-2615	366	1	2023	2023	NUM
eurjchem-2615	366	2	,	,	PUNCT
eurjchem-2615	366	3	141	141	NUM
eurjchem-2615	366	4	,	,	PUNCT
eurjchem-2615	366	5	106882	106882	NUM
eurjchem-2615	366	6	.	.	PUNCT
eurjchem-2615	367	1	[	[	X
eurjchem-2615	367	2	15	15	NUM
eurjchem-2615	367	3	]	]	PUNCT
eurjchem-2615	367	4	.	.	PUNCT
eurjchem-2615	368	1	ren	ren	PROPN
eurjchem-2615	368	2	,	,	PUNCT
eurjchem-2615	368	3	z.	z.	PROPN
eurjchem-2615	368	4	;	;	PUNCT
eurjchem-2615	368	5	coghi	coghi	PROPN
eurjchem-2615	368	6	,	,	PUNCT
eurjchem-2615	368	7	p.	p.	NOUN
eurjchem-2615	368	8	exploring	explore	VERB
eurjchem-2615	368	9	medicinal	medicinal	ADJ
eurjchem-2615	368	10	potential	potential	ADJ
eurjchem-2615	368	11	and	and	CCONJ
eurjchem-2615	368	12	drug	drug	NOUN
eurjchem-2615	368	13	delivery	delivery	NOUN
eurjchem-2615	368	14	solutions	solution	NOUN
eurjchem-2615	368	15	of	of	ADP
eurjchem-2615	368	16	celastrol	celastrol	NOUN
eurjchem-2615	368	17	from	from	ADP
eurjchem-2615	368	18	the	the	DET
eurjchem-2615	368	19	chinese	chinese	ADJ
eurjchem-2615	368	20	"	"	PUNCT
eurjchem-2615	368	21	thunder	thunder	NOUN
eurjchem-2615	368	22	of	of	ADP
eurjchem-2615	368	23	god	god	PROPN
eurjchem-2615	368	24	vine	vine	PROPN
eurjchem-2615	368	25	"	"	PUNCT
eurjchem-2615	368	26	.	.	PUNCT
eurjchem-2615	369	1	eur	eur	PROPN
eurjchem-2615	369	2	.	.	PUNCT
eurjchem-2615	370	1	j.	j.	PROPN
eurjchem-2615	370	2	chem	chem	PROPN
eurjchem-2615	370	3	.	.	PUNCT
eurjchem-2615	371	1	2024	2024	NUM
eurjchem-2615	371	2	,	,	PUNCT
eurjchem-2615	371	3	15	15	NUM
eurjchem-2615	371	4	(	(	PUNCT
eurjchem-2615	371	5	2	2	NUM
eurjchem-2615	371	6	)	)	PUNCT
eurjchem-2615	371	7	,	,	PUNCT
eurjchem-2615	371	8	194–204	194–204	NUM
eurjchem-2615	371	9	.	.	PUNCT
eurjchem-2615	372	1	[	[	X
eurjchem-2615	372	2	16	16	NUM
eurjchem-2615	372	3	]	]	PUNCT
eurjchem-2615	372	4	.	.	PUNCT
eurjchem-2615	373	1	bandi	bandi	PROPN
eurjchem-2615	373	2	,	,	PUNCT
eurjchem-2615	373	3	s.	s.	PROPN
eurjchem-2615	373	4	r.	r.	PROPN
eurjchem-2615	373	5	;	;	PUNCT
eurjchem-2615	373	6	kavitha	kavitha	PROPN
eurjchem-2615	373	7	,	,	PUNCT
eurjchem-2615	373	8	n.	n.	PROPN
eurjchem-2615	373	9	;	;	PUNCT
eurjchem-2615	373	10	nukala	nukala	PROPN
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eurjchem-2615	373	12	s.	s.	PROPN
eurjchem-2615	373	13	k.	k.	PROPN
eurjchem-2615	373	14	;	;	PUNCT
eurjchem-2615	373	15	thirukovela	thirukovela	PROPN
eurjchem-2615	373	16	,	,	PUNCT
eurjchem-2615	373	17	n.	n.	PROPN
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eurjchem-2615	373	21	,	,	PUNCT
eurjchem-2615	373	22	r.	r.	PROPN
eurjchem-2615	373	23	;	;	PUNCT
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eurjchem-2615	373	25	,	,	PUNCT
eurjchem-2615	373	26	r.	r.	PROPN
eurjchem-2615	373	27	;	;	PUNCT
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eurjchem-2615	373	30	s.	s.	PROPN
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eurjchem-2615	373	39	-	-	PUNCT
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eurjchem-2615	373	41	-	-	PUNCT
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eurjchem-2615	373	43	-	-	PUNCT
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eurjchem-2615	373	46	egfr	egfr	ADJ
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eurjchem-2615	373	49	agents	agent	NOUN
eurjchem-2615	373	50	.	.	PUNCT
eurjchem-2615	374	1	j.	j.	PROPN
eurjchem-2615	374	2	mol	mol	PROPN
eurjchem-2615	374	3	.	.	PROPN
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eurjchem-2615	374	5	.	.	PUNCT
eurjchem-2615	375	1	2023	2023	NUM
eurjchem-2615	375	2	,	,	PUNCT
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eurjchem-2615	375	4	,	,	PUNCT
eurjchem-2615	375	5	134378	134378	NUM
eurjchem-2615	375	6	.	.	PUNCT
eurjchem-2615	376	1	[	[	X
eurjchem-2615	376	2	17	17	NUM
eurjchem-2615	376	3	]	]	PUNCT
eurjchem-2615	376	4	.	.	PUNCT
eurjchem-2615	377	1	jamagne	jamagne	PROPN
eurjchem-2615	377	2	,	,	PUNCT
eurjchem-2615	377	3	r.	r.	PROPN
eurjchem-2615	377	4	;	;	PUNCT
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eurjchem-2615	377	6	,	,	PUNCT
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eurjchem-2615	377	8	j.	j.	PROPN
eurjchem-2615	377	9	;	;	PUNCT
eurjchem-2615	377	10	zhang	zhang	PROPN
eurjchem-2615	377	11	,	,	PUNCT
eurjchem-2615	377	12	z.	z.	PROPN
eurjchem-2615	377	13	;	;	PUNCT
eurjchem-2615	377	14	zango	zango	PROPN
eurjchem-2615	377	15	,	,	PUNCT
eurjchem-2615	377	16	g.	g.	PROPN
eurjchem-2615	377	17	;	;	PUNCT
eurjchem-2615	377	18	gibber	gibber	PROPN
eurjchem-2615	377	19	,	,	PUNCT
eurjchem-2615	377	20	b.	b.	PROPN
eurjchem-2615	377	21	;	;	PUNCT
eurjchem-2615	377	22	leigh	leigh	PROPN
eurjchem-2615	377	23	,	,	PUNCT
eurjchem-2615	377	24	d.	d.	PROPN
eurjchem-2615	377	25	a.	a.	PROPN
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eurjchem-2615	377	27	template	template	NOUN
eurjchem-2615	377	28	synthesis	synthesis	NOUN
eurjchem-2615	377	29	.	.	PUNCT
eurjchem-2615	378	1	chem	chem	NOUN
eurjchem-2615	378	2	.	.	PUNCT
eurjchem-2615	379	1	soc	soc	PROPN
eurjchem-2615	379	2	.	.	PUNCT
eurjchem-2615	380	1	rev	rev	PROPN
eurjchem-2615	380	2	.	.	PROPN
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eurjchem-2615	380	4	,	,	PUNCT
eurjchem-2615	380	5	53	53	NUM
eurjchem-2615	380	6	(	(	PUNCT
eurjchem-2615	380	7	20	20	NUM
eurjchem-2615	380	8	)	)	PUNCT
eurjchem-2615	380	9	,	,	PUNCT
eurjchem-2615	380	10	10216	10216	NUM
eurjchem-2615	380	11	–	–	PUNCT
eurjchem-2615	380	12	10252	10252	NUM
eurjchem-2615	380	13	.	.	PUNCT
eurjchem-2615	381	1	[	[	X
eurjchem-2615	381	2	18	18	NUM
eurjchem-2615	381	3	]	]	PUNCT
eurjchem-2615	381	4	.	.	PUNCT
eurjchem-2615	381	5	saraiva	saraiva	PROPN
eurjchem-2615	381	6	,	,	PUNCT
eurjchem-2615	381	7	n.	n.	PROPN
eurjchem-2615	381	8	m.	m.	NOUN
eurjchem-2615	381	9	;	;	PUNCT
eurjchem-2615	381	10	alves	alves	PROPN
eurjchem-2615	381	11	,	,	PUNCT
eurjchem-2615	381	12	a.	a.	NOUN
eurjchem-2615	381	13	;	;	PUNCT
eurjchem-2615	381	14	costa	costa	PROPN
eurjchem-2615	381	15	,	,	PUNCT
eurjchem-2615	381	16	p.	p.	PROPN
eurjchem-2615	381	17	c.	c.	PROPN
eurjchem-2615	381	18	;	;	PUNCT
eurjchem-2615	381	19	correia	correia	PROPN
eurjchem-2615	381	20	-	-	PUNCT
eurjchem-2615	381	21	da	da	PROPN
eurjchem-2615	381	22	-	-	PUNCT
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eurjchem-2615	381	24	,	,	PUNCT
eurjchem-2615	381	25	m.	m.	NOUN
eurjchem-2615	381	26	click	click	VERB
eurjchem-2615	381	27	chemistry	chemistry	NOUN
eurjchem-2615	381	28	in	in	ADP
eurjchem-2615	381	29	polymersome	polymersome	NOUN
eurjchem-2615	381	30	technology	technology	NOUN
eurjchem-2615	381	31	.	.	PUNCT
eurjchem-2615	382	1	pharmaceuticals	pharmaceutical	NOUN
eurjchem-2615	382	2	2024	2024	NUM
eurjchem-2615	382	3	,	,	PUNCT
eurjchem-2615	382	4	17	17	NUM
eurjchem-2615	382	5	(	(	PUNCT
eurjchem-2615	382	6	6	6	NUM
eurjchem-2615	382	7	)	)	PUNCT
eurjchem-2615	382	8	,	,	PUNCT
eurjchem-2615	382	9	747	747	NUM
eurjchem-2615	382	10	.	.	PUNCT
eurjchem-2615	383	1	[	[	X
eurjchem-2615	383	2	19	19	NUM
eurjchem-2615	383	3	]	]	PUNCT
eurjchem-2615	383	4	.	.	PUNCT
eurjchem-2615	384	1	agrahari	agrahari	PROPN
eurjchem-2615	384	2	,	,	PUNCT
eurjchem-2615	384	3	a.	a.	PROPN
eurjchem-2615	384	4	k.	k.	PROPN
eurjchem-2615	384	5	;	;	PUNCT
eurjchem-2615	384	6	bose	bose	PROPN
eurjchem-2615	384	7	,	,	PUNCT
eurjchem-2615	384	8	p.	p.	PROPN
eurjchem-2615	384	9	;	;	PUNCT
eurjchem-2615	384	10	jaiswal	jaiswal	PROPN
eurjchem-2615	384	11	,	,	PUNCT
eurjchem-2615	384	12	m.	m.	PROPN
eurjchem-2615	384	13	k.	k.	PROPN
eurjchem-2615	384	14	;	;	PUNCT
eurjchem-2615	384	15	rajkhowa	rajkhowa	ADJ
eurjchem-2615	384	16	,	,	PUNCT
eurjchem-2615	384	17	s.	s.	PROPN
eurjchem-2615	384	18	;	;	PUNCT
eurjchem-2615	384	19	singh	singh	PROPN
eurjchem-2615	384	20	,	,	PUNCT
eurjchem-2615	384	21	a.	a.	PROPN
eurjchem-2615	384	22	s.	s.	PROPN
eurjchem-2615	384	23	;	;	PUNCT
eurjchem-2615	384	24	hotha	hotha	NOUN
eurjchem-2615	384	25	,	,	PUNCT
eurjchem-2615	384	26	s.	s.	PROPN
eurjchem-2615	384	27	;	;	PUNCT
eurjchem-2615	384	28	mishra	mishra	PROPN
eurjchem-2615	384	29	,	,	PUNCT
eurjchem-2615	384	30	n.	n.	PROPN
eurjchem-2615	384	31	;	;	PUNCT
eurjchem-2615	384	32	tiwari	tiwari	PROPN
eurjchem-2615	384	33	,	,	PUNCT
eurjchem-2615	384	34	v.	v.	PROPN
eurjchem-2615	384	35	k.	k.	PROPN
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eurjchem-2615	384	37	click	click	VERB
eurjchem-2615	384	38	chemistry	chemistry	NOUN
eurjchem-2615	384	39	in	in	ADP
eurjchem-2615	384	40	glycoscience	glycoscience	NOUN
eurjchem-2615	384	41	and	and	CCONJ
eurjchem-2615	384	42	their	their	PRON
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eurjchem-2615	384	45	.	.	PUNCT
eurjchem-2615	385	1	chem	chem	PROPN
eurjchem-2615	385	2	.	.	PUNCT
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eurjchem-2615	386	2	.	.	PROPN
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eurjchem-2615	386	4	,	,	PUNCT
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eurjchem-2615	386	6	(	(	PUNCT
eurjchem-2615	386	7	13	13	NUM
eurjchem-2615	386	8	)	)	PUNCT
eurjchem-2615	386	9	,	,	PUNCT
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eurjchem-2615	386	11	.	.	PUNCT
eurjchem-2615	387	1	[	[	X
eurjchem-2615	387	2	20	20	NUM
eurjchem-2615	387	3	]	]	PUNCT
eurjchem-2615	387	4	.	.	PUNCT
eurjchem-2615	388	1	mamidyala	mamidyala	PROPN
eurjchem-2615	388	2	,	,	PUNCT
eurjchem-2615	388	3	s.	s.	PROPN
eurjchem-2615	388	4	k.	k.	PROPN
eurjchem-2615	388	5	;	;	PUNCT
eurjchem-2615	388	6	finn	finn	PROPN
eurjchem-2615	388	7	,	,	PUNCT
eurjchem-2615	388	8	m.	m.	NOUN
eurjchem-2615	388	9	g.	g.	PROPN
eurjchem-2615	388	10	in	in	ADP
eurjchem-2615	388	11	situ	situ	PROPN
eurjchem-2615	388	12	click	click	NOUN
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eurjchem-2615	388	14	:	:	PUNCT
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eurjchem-2615	388	17	binding	bind	VERB
eurjchem-2615	388	18	landscapes	landscape	NOUN
eurjchem-2615	388	19	of	of	ADP
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eurjchem-2615	388	21	molecules	molecule	NOUN
eurjchem-2615	388	22	.	.	PUNCT
eurjchem-2615	389	1	chem	chem	NOUN
eurjchem-2615	389	2	.	.	PUNCT
eurjchem-2615	390	1	soc	soc	PROPN
eurjchem-2615	390	2	.	.	PUNCT
eurjchem-2615	391	1	rev	rev	PROPN
eurjchem-2615	391	2	.	.	PROPN
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eurjchem-2615	391	4	,	,	PUNCT
eurjchem-2615	391	5	39	39	NUM
eurjchem-2615	391	6	(	(	PUNCT
eurjchem-2615	391	7	4	4	NUM
eurjchem-2615	391	8	)	)	PUNCT
eurjchem-2615	391	9	,	,	PUNCT
eurjchem-2615	391	10	1252	1252	NUM
eurjchem-2615	391	11	.	.	PUNCT
eurjchem-2615	392	1	http://dx.doi.org/10.13039/100006770	http://dx.doi.org/10.13039/100006770	NOUN
eurjchem-2615	392	2	mailto:2230028575@student.must.edu.mo	mailto:2230028575@student.must.edu.mo	PROPN
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eurjchem-2615	392	10	/	/	SYM
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eurjchem-2615	392	12	journal	journal	PROPN
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eurjchem-2615	392	15	16	16	NUM
eurjchem-2615	392	16	(	(	PUNCT
eurjchem-2615	392	17	1	1	NUM
eurjchem-2615	392	18	)	)	PUNCT
eurjchem-2615	392	19	(	(	PUNCT
eurjchem-2615	392	20	2025	2025	NUM
eurjchem-2615	392	21	)	)	PUNCT
eurjchem-2615	392	22	83	83	NUM
eurjchem-2615	392	23	-	-	SYM
eurjchem-2615	392	24	96	96	NUM
eurjchem-2615	392	25	95	95	NUM
eurjchem-2615	392	26	2025	2025	NUM
eurjchem-2615	392	27	–	–	PUNCT
eurjchem-2615	392	28	european	european	ADJ
eurjchem-2615	392	29	journal	journal	NOUN
eurjchem-2615	392	30	of	of	ADP
eurjchem-2615	392	31	chemistry	chemistry	NOUN
eurjchem-2615	392	32	–	–	PUNCT
eurjchem-2615	392	33	cc	cc	NOUN
eurjchem-2615	392	34	by	by	ADP
eurjchem-2615	392	35	nc	nc	PROPN
eurjchem-2615	392	36	–	–	PUNCT
eurjchem-2615	392	37	doi	doi	NOUN
eurjchem-2615	392	38	:	:	PUNCT
eurjchem-2615	392	39	10.5155	10.5155	NUM
eurjchem-2615	392	40	/	/	SYM
eurjchem-2615	392	41	eurjchem.16.1.83	eurjchem.16.1.83	PROPN
eurjchem-2615	392	42	-	-	PUNCT
eurjchem-2615	392	43	96.2615	96.2615	NUM
eurjchem-2615	392	44	[	[	X
eurjchem-2615	392	45	21	21	NUM
eurjchem-2615	392	46	]	]	PUNCT
eurjchem-2615	392	47	.	.	PUNCT
eurjchem-2615	393	1	kolb	kolb	PROPN
eurjchem-2615	393	2	,	,	PUNCT
eurjchem-2615	393	3	h.	h.	PROPN
eurjchem-2615	393	4	c.	c.	PROPN
eurjchem-2615	393	5	;	;	PUNCT
eurjchem-2615	393	6	finn	finn	PROPN
eurjchem-2615	393	7	,	,	PUNCT
eurjchem-2615	393	8	m.	m.	NOUN
eurjchem-2615	393	9	g.	g.	PROPN
eurjchem-2615	393	10	;	;	PUNCT
eurjchem-2615	393	11	sharpless	sharpless	PROPN
eurjchem-2615	393	12	,	,	PUNCT
eurjchem-2615	393	13	k.	k.	PROPN
eurjchem-2615	393	14	b.	b.	PROPN
eurjchem-2615	393	15	click	click	VERB
eurjchem-2615	393	16	chemistry	chemistry	NOUN
eurjchem-2615	393	17	:	:	PUNCT
eurjchem-2615	393	18	diverse	diverse	ADJ
eurjchem-2615	393	19	chemical	chemical	NOUN
eurjchem-2615	393	20	function	function	NOUN
eurjchem-2615	393	21	from	from	ADP
eurjchem-2615	393	22	a	a	DET
eurjchem-2615	393	23	few	few	ADJ
eurjchem-2615	393	24	good	good	ADJ
eurjchem-2615	393	25	reactions	reaction	NOUN
eurjchem-2615	393	26	.	.	PUNCT
eurjchem-2615	394	1	angew	angew	PROPN
eurjchem-2615	394	2	.	.	PUNCT
eurjchem-2615	395	1	chem	chem	PROPN
eurjchem-2615	395	2	.	.	PUNCT
eurjchem-2615	396	1	int	int	NOUN
eurjchem-2615	396	2	.	.	PUNCT
eurjchem-2615	397	1	ed	ed	NOUN
eurjchem-2615	397	2	.	.	PROPN
eurjchem-2615	398	1	2001	2001	NUM
eurjchem-2615	398	2	,	,	PUNCT
eurjchem-2615	398	3	40	40	NUM
eurjchem-2615	398	4	(	(	PUNCT
eurjchem-2615	398	5	11	11	NUM
eurjchem-2615	398	6	)	)	PUNCT
eurjchem-2615	398	7	,	,	PUNCT
eurjchem-2615	398	8	2004–2021	2004–2021	NUM
eurjchem-2615	398	9	.	.	PUNCT
eurjchem-2615	399	1	[	[	X
eurjchem-2615	399	2	22	22	NUM
eurjchem-2615	399	3	]	]	PUNCT
eurjchem-2615	399	4	.	.	PUNCT
eurjchem-2615	400	1	agalave	agalave	PROPN
eurjchem-2615	400	2	,	,	PUNCT
eurjchem-2615	400	3	s.	s.	PROPN
eurjchem-2615	400	4	g.	g.	PROPN
eurjchem-2615	400	5	;	;	PUNCT
eurjchem-2615	400	6	maujan	maujan	PROPN
eurjchem-2615	400	7	,	,	PUNCT
eurjchem-2615	400	8	s.	s.	PROPN
eurjchem-2615	400	9	r.	r.	PROPN
eurjchem-2615	400	10	;	;	PUNCT
eurjchem-2615	400	11	pore	pore	VERB
eurjchem-2615	400	12	,	,	PUNCT
eurjchem-2615	400	13	v.	v.	CCONJ
eurjchem-2615	400	14	s.	s.	PROPN
eurjchem-2615	400	15	click	click	VERB
eurjchem-2615	400	16	chemistry	chemistry	NOUN
eurjchem-2615	400	17	:	:	PUNCT
eurjchem-2615	401	1	1,2,3	1,2,3	NUM
eurjchem-2615	401	2	-	-	NOUN
eurjchem-2615	401	3	triazoles	triazole	NOUN
eurjchem-2615	401	4	as	as	ADP
eurjchem-2615	401	5	pharmacophores	pharmacophore	NOUN
eurjchem-2615	401	6	.	.	PUNCT
eurjchem-2615	402	1	chemistry	chemistry	NOUN
eurjchem-2615	402	2	an	an	DET
eurjchem-2615	402	3	asian	asian	ADJ
eurjchem-2615	402	4	journal	journal	NOUN
eurjchem-2615	402	5	2011	2011	NUM
eurjchem-2615	402	6	,	,	PUNCT
eurjchem-2615	402	7	6	6	NUM
eurjchem-2615	402	8	(	(	PUNCT
eurjchem-2615	402	9	10	10	NUM
eurjchem-2615	402	10	)	)	PUNCT
eurjchem-2615	402	11	,	,	PUNCT
eurjchem-2615	402	12	2696	2696	NUM
eurjchem-2615	402	13	–	–	PUNCT
eurjchem-2615	402	14	2718	2718	NUM
eurjchem-2615	402	15	.	.	PUNCT
eurjchem-2615	403	1	[	[	X
eurjchem-2615	403	2	23	23	NUM
eurjchem-2615	403	3	]	]	PUNCT
eurjchem-2615	403	4	.	.	PUNCT
eurjchem-2615	404	1	teneva	teneva	PROPN
eurjchem-2615	404	2	,	,	PUNCT
eurjchem-2615	404	3	y.	y.	PROPN
eurjchem-2615	404	4	;	;	PUNCT
eurjchem-2615	404	5	simeonova	simeonova	PROPN
eurjchem-2615	404	6	,	,	PUNCT
eurjchem-2615	404	7	r.	r.	PROPN
eurjchem-2615	404	8	;	;	PUNCT
eurjchem-2615	404	9	valcheva	valcheva	PROPN
eurjchem-2615	404	10	,	,	PUNCT
eurjchem-2615	404	11	v.	v.	PROPN
eurjchem-2615	404	12	;	;	PUNCT
eurjchem-2615	404	13	angelova	angelova	PROPN
eurjchem-2615	404	14	,	,	PUNCT
eurjchem-2615	404	15	v.	v.	ADP
eurjchem-2615	404	16	t.	t.	PROPN
eurjchem-2615	404	17	recent	recent	ADJ
eurjchem-2615	404	18	advances	advance	NOUN
eurjchem-2615	404	19	in	in	ADP
eurjchem-2615	404	20	anti	anti	ADJ
eurjchem-2615	404	21	-	-	ADJ
eurjchem-2615	404	22	tuberculosis	tuberculosis	ADJ
eurjchem-2615	404	23	drug	drug	NOUN
eurjchem-2615	404	24	discovery	discovery	NOUN
eurjchem-2615	404	25	based	base	VERB
eurjchem-2615	404	26	on	on	ADP
eurjchem-2615	404	27	hydrazide	hydrazide	ADJ
eurjchem-2615	404	28	–	–	PUNCT
eurjchem-2615	404	29	hydrazone	hydrazone	NOUN
eurjchem-2615	404	30	and	and	CCONJ
eurjchem-2615	404	31	thiadiazole	thiadiazole	NOUN
eurjchem-2615	404	32	derivatives	derivative	NOUN
eurjchem-2615	404	33	targeting	target	VERB
eurjchem-2615	404	34	inha	inha	NOUN
eurjchem-2615	404	35	.	.	PUNCT
eurjchem-2615	405	1	pharmaceuticals	pharmaceutical	NOUN
eurjchem-2615	405	2	2023	2023	NUM
eurjchem-2615	405	3	,	,	PUNCT
eurjchem-2615	405	4	16	16	NUM
eurjchem-2615	405	5	(	(	PUNCT
eurjchem-2615	405	6	4	4	NUM
eurjchem-2615	405	7	)	)	PUNCT
eurjchem-2615	405	8	,	,	PUNCT
eurjchem-2615	405	9	484	484	NUM
eurjchem-2615	405	10	.	.	PUNCT
eurjchem-2615	406	1	[	[	X
eurjchem-2615	406	2	24	24	NUM
eurjchem-2615	406	3	]	]	PUNCT
eurjchem-2615	406	4	.	.	PUNCT
eurjchem-2615	407	1	palomino	palomino	PROPN
eurjchem-2615	407	2	,	,	PUNCT
eurjchem-2615	407	3	j.	j.	PROPN
eurjchem-2615	407	4	c.	c.	PROPN
eurjchem-2615	407	5	current	current	ADJ
eurjchem-2615	407	6	developments	development	NOUN
eurjchem-2615	407	7	and	and	CCONJ
eurjchem-2615	407	8	future	future	ADJ
eurjchem-2615	407	9	perspectives	perspective	NOUN
eurjchem-2615	407	10	for	for	ADP
eurjchem-2615	407	11	tb	tb	ADP
eurjchem-2615	407	12	diagnostics	diagnostic	NOUN
eurjchem-2615	407	13	.	.	PUNCT
eurjchem-2615	408	1	future	future	ADJ
eurjchem-2615	408	2	microbiol	microbiol	PROPN
eurjchem-2615	408	3	.	.	PUNCT
eurjchem-2615	409	1	2011	2011	NUM
eurjchem-2615	409	2	,	,	PUNCT
eurjchem-2615	409	3	7	7	NUM
eurjchem-2615	409	4	(	(	PUNCT
eurjchem-2615	409	5	1	1	NUM
eurjchem-2615	409	6	)	)	PUNCT
eurjchem-2615	409	7	,	,	PUNCT
eurjchem-2615	409	8	59–71	59–71	NUM
eurjchem-2615	409	9	.	.	PUNCT
eurjchem-2615	410	1	[	[	X
eurjchem-2615	410	2	25	25	NUM
eurjchem-2615	410	3	]	]	PUNCT
eurjchem-2615	410	4	.	.	PUNCT
eurjchem-2615	410	5	peloquin	peloquin	PROPN
eurjchem-2615	410	6	,	,	PUNCT
eurjchem-2615	410	7	c.	c.	PROPN
eurjchem-2615	410	8	a.	a.	PROPN
eurjchem-2615	410	9	;	;	PUNCT
eurjchem-2615	410	10	davies	davy	NOUN
eurjchem-2615	410	11	,	,	PUNCT
eurjchem-2615	410	12	g.	g.	PROPN
eurjchem-2615	410	13	r.	r.	PROPN
eurjchem-2615	411	1	the	the	DET
eurjchem-2615	411	2	treatment	treatment	NOUN
eurjchem-2615	411	3	of	of	ADP
eurjchem-2615	411	4	tuberculosis	tuberculosis	NOUN
eurjchem-2615	411	5	.	.	PUNCT
eurjchem-2615	412	1	clin	clin	PROPN
eurjchem-2615	412	2	.	.	PUNCT
eurjchem-2615	413	1	pharma	pharma	PROPN
eurjchem-2615	413	2	therapeutics	therapeutic	NOUN
eurjchem-2615	413	3	2021	2021	NUM
eurjchem-2615	413	4	,	,	PUNCT
eurjchem-2615	413	5	110	110	NUM
eurjchem-2615	413	6	(	(	PUNCT
eurjchem-2615	413	7	6	6	NUM
eurjchem-2615	413	8	)	)	PUNCT
eurjchem-2615	413	9	,	,	PUNCT
eurjchem-2615	413	10	1455–1466	1455–1466	NUM
eurjchem-2615	413	11	.	.	PUNCT
eurjchem-2615	414	1	[	[	X
eurjchem-2615	414	2	26	26	NUM
eurjchem-2615	414	3	]	]	SYM
eurjchem-2615	414	4	.	.	PUNCT
eurjchem-2615	415	1	inturi	inturi	PROPN
eurjchem-2615	415	2	,	,	PUNCT
eurjchem-2615	415	3	b.	b.	PROPN
eurjchem-2615	415	4	;	;	PUNCT
eurjchem-2615	415	5	pujar	pujar	NOUN
eurjchem-2615	415	6	,	,	PUNCT
eurjchem-2615	415	7	g.	g.	PROPN
eurjchem-2615	415	8	v.	v.	PROPN
eurjchem-2615	415	9	;	;	PUNCT
eurjchem-2615	415	10	purohit	purohit	PROPN
eurjchem-2615	415	11	,	,	PUNCT
eurjchem-2615	415	12	m.	m.	NOUN
eurjchem-2615	415	13	n.	n.	PROPN
eurjchem-2615	416	1	recent	recent	ADJ
eurjchem-2615	416	2	advances	advance	NOUN
eurjchem-2615	416	3	and	and	CCONJ
eurjchem-2615	416	4	structural	structural	ADJ
eurjchem-2615	416	5	features	feature	NOUN
eurjchem-2615	416	6	of	of	ADP
eurjchem-2615	416	7	enoyl	enoyl	NOUN
eurjchem-2615	416	8	-	-	PUNCT
eurjchem-2615	416	9	acp	acp	PROPN
eurjchem-2615	416	10	reductase	reductase	NOUN
eurjchem-2615	416	11	inhibitors	inhibitor	NOUN
eurjchem-2615	416	12	of	of	ADP
eurjchem-2615	416	13	mycobacterium	mycobacterium	NOUN
eurjchem-2615	416	14	tuberculosis	tuberculosis	NOUN
eurjchem-2615	416	15	.	.	PUNCT
eurjchem-2615	417	1	arch	arch	NOUN
eurjchem-2615	417	2	.	.	PUNCT
eurjchem-2615	418	1	pharm	pharm	NOUN
eurjchem-2615	418	2	.	.	PUNCT
eurjchem-2615	419	1	2016	2016	NUM
eurjchem-2615	419	2	,	,	PUNCT
eurjchem-2615	419	3	349	349	NUM
eurjchem-2615	419	4	(	(	PUNCT
eurjchem-2615	419	5	11	11	NUM
eurjchem-2615	419	6	)	)	PUNCT
eurjchem-2615	419	7	,	,	PUNCT
eurjchem-2615	419	8	817–826	817–826	NUM
eurjchem-2615	419	9	.	.	PUNCT
eurjchem-2615	420	1	[	[	X
eurjchem-2615	420	2	27	27	NUM
eurjchem-2615	420	3	]	]	PUNCT
eurjchem-2615	420	4	.	.	PUNCT
eurjchem-2615	421	1	karaźniewicz	karaźniewicz	PROPN
eurjchem-2615	421	2	-	-	PUNCT
eurjchem-2615	421	3	łada	łada	PROPN
eurjchem-2615	421	4	,	,	PUNCT
eurjchem-2615	421	5	m.	m.	NOUN
eurjchem-2615	421	6	;	;	PUNCT
eurjchem-2615	421	7	kosicka	kosicka	NOUN
eurjchem-2615	421	8	-	-	PUNCT
eurjchem-2615	421	9	noworzyń	noworzyń	PROPN
eurjchem-2615	421	10	,	,	PUNCT
eurjchem-2615	421	11	k.	k.	PROPN
eurjchem-2615	421	12	;	;	PUNCT
eurjchem-2615	421	13	rao	rao	PROPN
eurjchem-2615	421	14	,	,	PUNCT
eurjchem-2615	421	15	p.	p.	PROPN
eurjchem-2615	421	16	;	;	PUNCT
eurjchem-2615	421	17	modi	modi	PROPN
eurjchem-2615	421	18	,	,	PUNCT
eurjchem-2615	421	19	n.	n.	PROPN
eurjchem-2615	421	20	;	;	PUNCT
eurjchem-2615	421	21	xie	xie	PROPN
eurjchem-2615	421	22	,	,	PUNCT
eurjchem-2615	421	23	y.	y.	PROPN
eurjchem-2615	421	24	l.	l.	PROPN
eurjchem-2615	421	25	;	;	PUNCT
eurjchem-2615	421	26	heysell	heysell	PROPN
eurjchem-2615	421	27	,	,	PUNCT
eurjchem-2615	421	28	s.	s.	PROPN
eurjchem-2615	421	29	k.	k.	PROPN
eurjchem-2615	421	30	;	;	PUNCT
eurjchem-2615	421	31	kagan	kagan	PROPN
eurjchem-2615	421	32	,	,	PUNCT
eurjchem-2615	421	33	l.	l.	PROPN
eurjchem-2615	421	34	new	new	ADJ
eurjchem-2615	421	35	approach	approach	NOUN
eurjchem-2615	421	36	to	to	AUX
eurjchem-2615	421	37	rifampicin	rifampicin	VERB
eurjchem-2615	421	38	stability	stability	NOUN
eurjchem-2615	421	39	and	and	CCONJ
eurjchem-2615	421	40	first	first	ADJ
eurjchem-2615	421	41	-	-	PUNCT
eurjchem-2615	421	42	line	line	NOUN
eurjchem-2615	421	43	anti	anti	ADJ
eurjchem-2615	421	44	-	-	ADJ
eurjchem-2615	421	45	tubercular	tubercular	ADJ
eurjchem-2615	421	46	drug	drug	NOUN
eurjchem-2615	421	47	pharmacokinetics	pharmacokinetic	NOUN
eurjchem-2615	421	48	by	by	ADP
eurjchem-2615	421	49	uplc	uplc	ADJ
eurjchem-2615	421	50	-	-	PUNCT
eurjchem-2615	421	51	ms	ms	PROPN
eurjchem-2615	421	52	/	/	SYM
eurjchem-2615	421	53	ms	ms	PROPN
eurjchem-2615	421	54	.	.	PROPN
eurjchem-2615	421	55	j.	j.	PROPN
eurjchem-2615	421	56	pharm	pharm	PROPN
eurjchem-2615	421	57	.	.	PUNCT
eurjchem-2615	421	58	biomed	biome	VERB
eurjchem-2615	421	59	.	.	PUNCT
eurjchem-2615	422	1	anal	anal	ADJ
eurjchem-2615	422	2	.	.	PUNCT
eurjchem-2615	423	1	2023	2023	NUM
eurjchem-2615	423	2	,	,	PUNCT
eurjchem-2615	423	3	235	235	NUM
eurjchem-2615	423	4	,	,	PUNCT
eurjchem-2615	423	5	115650	115650	NUM
eurjchem-2615	423	6	.	.	PUNCT
eurjchem-2615	424	1	[	[	X
eurjchem-2615	424	2	28	28	NUM
eurjchem-2615	424	3	]	]	PUNCT
eurjchem-2615	424	4	.	.	PUNCT
eurjchem-2615	425	1	sutradhar	sutradhar	PROPN
eurjchem-2615	425	2	,	,	PUNCT
eurjchem-2615	425	3	i.	i.	PROPN
eurjchem-2615	425	4	;	;	PUNCT
eurjchem-2615	425	5	zaman	zaman	PROPN
eurjchem-2615	425	6	,	,	PUNCT
eurjchem-2615	425	7	m.	m.	NOUN
eurjchem-2615	425	8	h.	h.	PROPN
eurjchem-2615	425	9	evaluation	evaluation	NOUN
eurjchem-2615	425	10	of	of	ADP
eurjchem-2615	425	11	the	the	DET
eurjchem-2615	425	12	effect	effect	NOUN
eurjchem-2615	425	13	of	of	ADP
eurjchem-2615	425	14	temperature	temperature	NOUN
eurjchem-2615	425	15	on	on	ADP
eurjchem-2615	425	16	the	the	DET
eurjchem-2615	425	17	stability	stability	NOUN
eurjchem-2615	425	18	and	and	CCONJ
eurjchem-2615	425	19	antimicrobial	antimicrobial	ADJ
eurjchem-2615	425	20	activity	activity	NOUN
eurjchem-2615	425	21	of	of	ADP
eurjchem-2615	425	22	rifampicin	rifampicin	VERB
eurjchem-2615	425	23	quinone	quinone	NOUN
eurjchem-2615	425	24	.	.	PUNCT
eurjchem-2615	426	1	j.	j.	PROPN
eurjchem-2615	426	2	pharm	pharm	PROPN
eurjchem-2615	426	3	.	.	PUNCT
eurjchem-2615	426	4	biomed	biome	VERB
eurjchem-2615	426	5	.	.	PUNCT
eurjchem-2615	427	1	anal	anal	ADJ
eurjchem-2615	427	2	.	.	PUNCT
eurjchem-2615	427	3	2021	2021	NUM
eurjchem-2615	427	4	,	,	PUNCT
eurjchem-2615	427	5	197	197	NUM
eurjchem-2615	427	6	,	,	PUNCT
eurjchem-2615	427	7	113941	113941	NUM
eurjchem-2615	427	8	.	.	PUNCT
eurjchem-2615	428	1	[	[	X
eurjchem-2615	428	2	29	29	NUM
eurjchem-2615	428	3	]	]	PUNCT
eurjchem-2615	428	4	.	.	PUNCT
eurjchem-2615	429	1	thirumurugan	thirumurugan	PROPN
eurjchem-2615	429	2	,	,	PUNCT
eurjchem-2615	429	3	p.	p.	NOUN
eurjchem-2615	429	4	;	;	PUNCT
eurjchem-2615	429	5	matosiuk	matosiuk	NOUN
eurjchem-2615	429	6	,	,	PUNCT
eurjchem-2615	429	7	d.	d.	PROPN
eurjchem-2615	429	8	;	;	PUNCT
eurjchem-2615	429	9	jozwiak	jozwiak	PROPN
eurjchem-2615	429	10	,	,	PUNCT
eurjchem-2615	429	11	k.	k.	PROPN
eurjchem-2615	429	12	click	click	VERB
eurjchem-2615	429	13	chemistry	chemistry	NOUN
eurjchem-2615	429	14	for	for	ADP
eurjchem-2615	429	15	drug	drug	NOUN
eurjchem-2615	429	16	development	development	NOUN
eurjchem-2615	429	17	and	and	CCONJ
eurjchem-2615	429	18	diverse	diverse	ADJ
eurjchem-2615	429	19	chemical	chemical	ADJ
eurjchem-2615	429	20	–	–	PUNCT
eurjchem-2615	429	21	biology	biology	NOUN
eurjchem-2615	429	22	applications	application	NOUN
eurjchem-2615	429	23	.	.	PUNCT
eurjchem-2615	430	1	chem	chem	PROPN
eurjchem-2615	430	2	.	.	PUNCT
eurjchem-2615	431	1	rev	rev	PROPN
eurjchem-2615	431	2	.	.	PROPN
eurjchem-2615	431	3	2013	2013	NUM
eurjchem-2615	431	4	,	,	PUNCT
eurjchem-2615	431	5	113	113	NUM
eurjchem-2615	431	6	(	(	PUNCT
eurjchem-2615	431	7	7	7	NUM
eurjchem-2615	431	8	)	)	PUNCT
eurjchem-2615	431	9	,	,	PUNCT
eurjchem-2615	431	10	4905–4979	4905–4979	NOUN
eurjchem-2615	431	11	.	.	PUNCT
eurjchem-2615	432	1	[	[	X
eurjchem-2615	432	2	30	30	NUM
eurjchem-2615	432	3	]	]	PUNCT
eurjchem-2615	432	4	.	.	PUNCT
eurjchem-2615	433	1	li	li	PROPN
eurjchem-2615	433	2	,	,	PUNCT
eurjchem-2615	433	3	l.	l.	PROPN
eurjchem-2615	433	4	;	;	PUNCT
eurjchem-2615	433	5	zhang	zhang	PROPN
eurjchem-2615	433	6	,	,	PUNCT
eurjchem-2615	433	7	z.	z.	PROPN
eurjchem-2615	433	8	development	development	PROPN
eurjchem-2615	433	9	and	and	CCONJ
eurjchem-2615	433	10	applications	application	NOUN
eurjchem-2615	433	11	of	of	ADP
eurjchem-2615	433	12	the	the	DET
eurjchem-2615	433	13	coppercatalyzed	coppercatalyze	VERB
eurjchem-2615	433	14	azide	azide	NOUN
eurjchem-2615	433	15	-	-	PUNCT
eurjchem-2615	433	16	alkyne	alkyne	NOUN
eurjchem-2615	433	17	cycloaddition	cycloaddition	NOUN
eurjchem-2615	433	18	(	(	PUNCT
eurjchem-2615	433	19	cuaac	cuaac	NOUN
eurjchem-2615	433	20	)	)	PUNCT
eurjchem-2615	433	21	as	as	ADP
eurjchem-2615	433	22	a	a	DET
eurjchem-2615	433	23	bioorthogonal	bioorthogonal	ADJ
eurjchem-2615	433	24	reaction	reaction	NOUN
eurjchem-2615	433	25	.	.	PUNCT
eurjchem-2615	434	1	molecules	molecule	NOUN
eurjchem-2615	434	2	2016	2016	NUM
eurjchem-2615	434	3	,	,	PUNCT
eurjchem-2615	434	4	21	21	NUM
eurjchem-2615	434	5	(	(	PUNCT
eurjchem-2615	434	6	10	10	NUM
eurjchem-2615	434	7	)	)	PUNCT
eurjchem-2615	434	8	,	,	PUNCT
eurjchem-2615	434	9	1393	1393	NUM
eurjchem-2615	434	10	.	.	PUNCT
eurjchem-2615	435	1	[	[	X
eurjchem-2615	435	2	31	31	NUM
eurjchem-2615	435	3	]	]	PUNCT
eurjchem-2615	435	4	.	.	PUNCT
eurjchem-2615	436	1	sharma	sharma	PROPN
eurjchem-2615	436	2	,	,	PUNCT
eurjchem-2615	436	3	a.	a.	NOUN
eurjchem-2615	436	4	;	;	PUNCT
eurjchem-2615	436	5	agrahari	agrahari	PROPN
eurjchem-2615	436	6	,	,	PUNCT
eurjchem-2615	436	7	a.	a.	PROPN
eurjchem-2615	436	8	k.	k.	PROPN
eurjchem-2615	436	9	;	;	PUNCT
eurjchem-2615	436	10	rajkhowa	rajkhowa	ADJ
eurjchem-2615	436	11	,	,	PUNCT
eurjchem-2615	436	12	s.	s.	PROPN
eurjchem-2615	436	13	;	;	PUNCT
eurjchem-2615	436	14	tiwari	tiwari	PROPN
eurjchem-2615	436	15	,	,	PUNCT
eurjchem-2615	436	16	v.	v.	PROPN
eurjchem-2615	436	17	k.	k.	NOUN
eurjchem-2615	436	18	emerging	emerge	VERB
eurjchem-2615	436	19	impact	impact	NOUN
eurjchem-2615	436	20	of	of	ADP
eurjchem-2615	436	21	triazoles	triazole	NOUN
eurjchem-2615	436	22	as	as	ADP
eurjchem-2615	436	23	anti	anti	ADJ
eurjchem-2615	436	24	-	-	ADJ
eurjchem-2615	436	25	tubercular	tubercular	ADJ
eurjchem-2615	436	26	agent	agent	NOUN
eurjchem-2615	436	27	.	.	PUNCT
eurjchem-2615	437	1	eur	eur	PROPN
eurjchem-2615	437	2	.	.	PUNCT
eurjchem-2615	438	1	j.	j.	PROPN
eurjchem-2615	438	2	med	med	PROPN
eurjchem-2615	438	3	.	.	PROPN
eurjchem-2615	438	4	chem	chem	PROPN
eurjchem-2615	438	5	.	.	PUNCT
eurjchem-2615	439	1	2022	2022	NUM
eurjchem-2615	439	2	,	,	PUNCT
eurjchem-2615	439	3	238	238	NUM
eurjchem-2615	439	4	,	,	PUNCT
eurjchem-2615	439	5	114454	114454	NUM
eurjchem-2615	439	6	.	.	PUNCT
eurjchem-2615	440	1	[	[	X
eurjchem-2615	440	2	32	32	NUM
eurjchem-2615	440	3	]	]	PUNCT
eurjchem-2615	440	4	.	.	PUNCT
eurjchem-2615	440	5	bonandi	bonandi	PROPN
eurjchem-2615	440	6	,	,	PUNCT
eurjchem-2615	440	7	e.	e.	PROPN
eurjchem-2615	440	8	;	;	PUNCT
eurjchem-2615	440	9	christodoulou	christodoulou	PROPN
eurjchem-2615	440	10	,	,	PUNCT
eurjchem-2615	440	11	m.	m.	NOUN
eurjchem-2615	440	12	s.	s.	PROPN
eurjchem-2615	440	13	;	;	PUNCT
eurjchem-2615	440	14	fumagalli	fumagalli	PROPN
eurjchem-2615	440	15	,	,	PUNCT
eurjchem-2615	440	16	g.	g.	NOUN
eurjchem-2615	440	17	;	;	PUNCT
eurjchem-2615	440	18	perdicchia	perdicchia	VERB
eurjchem-2615	440	19	,	,	PUNCT
eurjchem-2615	440	20	d.	d.	PROPN
eurjchem-2615	440	21	;	;	PUNCT
eurjchem-2615	440	22	rastelli	rastelli	PROPN
eurjchem-2615	440	23	,	,	PUNCT
eurjchem-2615	440	24	g.	g.	PROPN
eurjchem-2615	440	25	;	;	PUNCT
eurjchem-2615	440	26	passarella	passarella	PROPN
eurjchem-2615	440	27	,	,	PUNCT
eurjchem-2615	440	28	d.	d.	NOUN
eurjchem-2615	440	29	the	the	DET
eurjchem-2615	440	30	1,2,3	1,2,3	NUM
eurjchem-2615	440	31	-	-	ADJ
eurjchem-2615	440	32	triazole	triazole	ADJ
eurjchem-2615	440	33	ring	ring	NOUN
eurjchem-2615	440	34	as	as	ADP
eurjchem-2615	440	35	a	a	DET
eurjchem-2615	440	36	bioisostere	bioisostere	NOUN
eurjchem-2615	440	37	in	in	ADP
eurjchem-2615	440	38	medicinal	medicinal	ADJ
eurjchem-2615	440	39	chemistry	chemistry	NOUN
eurjchem-2615	440	40	.	.	PUNCT
eurjchem-2615	441	1	drug	drug	NOUN
eurjchem-2615	441	2	discov	discov	NOUN
eurjchem-2615	441	3	.	.	PUNCT
eurjchem-2615	442	1	today	today	NOUN
eurjchem-2615	442	2	2017	2017	NUM
eurjchem-2615	442	3	,	,	PUNCT
eurjchem-2615	442	4	22	22	NUM
eurjchem-2615	442	5	(	(	PUNCT
eurjchem-2615	442	6	10	10	NUM
eurjchem-2615	442	7	)	)	PUNCT
eurjchem-2615	442	8	,	,	PUNCT
eurjchem-2615	442	9	1572–1581	1572–1581	NUM
eurjchem-2615	442	10	.	.	PUNCT
eurjchem-2615	443	1	[	[	X
eurjchem-2615	443	2	33	33	NUM
eurjchem-2615	443	3	]	]	PUNCT
eurjchem-2615	443	4	.	.	PUNCT
eurjchem-2615	444	1	voigt	voigt	PROPN
eurjchem-2615	444	2	,	,	PUNCT
eurjchem-2615	444	3	m.	m.	NOUN
eurjchem-2615	444	4	;	;	PUNCT
eurjchem-2615	444	5	fritz	fritz	PROPN
eurjchem-2615	444	6	,	,	PUNCT
eurjchem-2615	444	7	t.	t.	PROPN
eurjchem-2615	444	8	;	;	PUNCT
eurjchem-2615	444	9	worm	worm	NOUN
eurjchem-2615	444	10	,	,	PUNCT
eurjchem-2615	444	11	m.	m.	NOUN
eurjchem-2615	444	12	;	;	PUNCT
eurjchem-2615	444	13	frey	frey	PROPN
eurjchem-2615	444	14	,	,	PUNCT
eurjchem-2615	444	15	h.	h.	PROPN
eurjchem-2615	444	16	;	;	PUNCT
eurjchem-2615	444	17	helm	helm	NOUN
eurjchem-2615	444	18	,	,	PUNCT
eurjchem-2615	444	19	m.	m.	NOUN
eurjchem-2615	444	20	surface	surface	NOUN
eurjchem-2615	444	21	modification	modification	NOUN
eurjchem-2615	444	22	of	of	ADP
eurjchem-2615	444	23	nanoparticles	nanoparticle	NOUN
eurjchem-2615	444	24	and	and	CCONJ
eurjchem-2615	444	25	nanovesicles	nanovesicle	NOUN
eurjchem-2615	444	26	via	via	ADP
eurjchem-2615	444	27	click	click	NOUN
eurjchem-2615	444	28	-	-	PUNCT
eurjchem-2615	444	29	chemistry	chemistry	NOUN
eurjchem-2615	444	30	.	.	PUNCT
eurjchem-2615	445	1	methods	method	NOUN
eurjchem-2615	445	2	mol	mol	PROPN
eurjchem-2615	445	3	.	.	PUNCT
eurjchem-2615	446	1	biol	biol	PROPN
eurjchem-2615	446	2	.	.	PUNCT
eurjchem-2615	447	1	2019	2019	NUM
eurjchem-2615	447	2	,	,	PUNCT
eurjchem-2615	447	3	235–245	235–245	NUM
eurjchem-2615	447	4	.	.	PUNCT
eurjchem-2615	448	1	[	[	X
eurjchem-2615	448	2	34	34	NUM
eurjchem-2615	448	3	]	]	PUNCT
eurjchem-2615	448	4	.	.	PUNCT
eurjchem-2615	448	5	shaikh	shaikh	PROPN
eurjchem-2615	448	6	,	,	PUNCT
eurjchem-2615	448	7	m.	m.	PROPN
eurjchem-2615	448	8	h.	h.	PROPN
eurjchem-2615	448	9	;	;	PUNCT
eurjchem-2615	448	10	subhedar	subhedar	ADV
eurjchem-2615	448	11	,	,	PUNCT
eurjchem-2615	448	12	d.	d.	PROPN
eurjchem-2615	448	13	d.	d.	PROPN
eurjchem-2615	448	14	;	;	PUNCT
eurjchem-2615	448	15	arkile	arkile	NOUN
eurjchem-2615	448	16	,	,	PUNCT
eurjchem-2615	448	17	m.	m.	NOUN
eurjchem-2615	448	18	;	;	PUNCT
eurjchem-2615	448	19	khedkar	khedkar	PROPN
eurjchem-2615	448	20	,	,	PUNCT
eurjchem-2615	448	21	v.	v.	ADP
eurjchem-2615	448	22	m.	m.	NOUN
eurjchem-2615	448	23	;	;	PUNCT
eurjchem-2615	448	24	jadhav	jadhav	PROPN
eurjchem-2615	448	25	,	,	PUNCT
eurjchem-2615	448	26	n.	n.	PROPN
eurjchem-2615	448	27	;	;	PUNCT
eurjchem-2615	448	28	sarkar	sarkar	PROPN
eurjchem-2615	448	29	,	,	PUNCT
eurjchem-2615	448	30	d.	d.	PROPN
eurjchem-2615	448	31	;	;	PUNCT
eurjchem-2615	448	32	shingate	shingate	VERB
eurjchem-2615	448	33	,	,	PUNCT
eurjchem-2615	448	34	b.	b.	PROPN
eurjchem-2615	448	35	b.	b.	PROPN
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eurjchem-2615	448	38	bioactivity	bioactivity	NOUN
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eurjchem-2615	448	40	novel	novel	ADJ
eurjchem-2615	448	41	triazole	triazole	NOUN
eurjchem-2615	448	42	incorporated	incorporate	VERB
eurjchem-2615	448	43	benzothiazinone	benzothiazinone	NOUN
eurjchem-2615	448	44	derivatives	derivative	NOUN
eurjchem-2615	448	45	as	as	ADP
eurjchem-2615	448	46	antitubercular	antitubercular	ADJ
eurjchem-2615	448	47	and	and	CCONJ
eurjchem-2615	448	48	antioxidant	antioxidant	ADJ
eurjchem-2615	448	49	agent	agent	NOUN
eurjchem-2615	448	50	.	.	PUNCT
eurjchem-2615	449	1	bioorg	bioorg	PROPN
eurjchem-2615	449	2	.	.	PUNCT
eurjchem-2615	450	1	med	med	PROPN
eurjchem-2615	450	2	.	.	PROPN
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eurjchem-2615	450	4	.	.	PUNCT
eurjchem-2615	451	1	lett	lett	PROPN
eurjchem-2615	451	2	.	.	PROPN
eurjchem-2615	452	1	2016	2016	NUM
eurjchem-2615	452	2	,	,	PUNCT
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eurjchem-2615	452	4	(	(	PUNCT
eurjchem-2615	452	5	2	2	NUM
eurjchem-2615	452	6	)	)	PUNCT
eurjchem-2615	452	7	,	,	PUNCT
eurjchem-2615	452	8	561–569	561–569	NUM
eurjchem-2615	452	9	.	.	PUNCT
eurjchem-2615	453	1	[	[	X
eurjchem-2615	453	2	35	35	NUM
eurjchem-2615	453	3	]	]	PUNCT
eurjchem-2615	453	4	.	.	PUNCT
eurjchem-2615	454	1	jewett	jewett	PROPN
eurjchem-2615	454	2	,	,	PUNCT
eurjchem-2615	454	3	j.	j.	PROPN
eurjchem-2615	454	4	c.	c.	PROPN
eurjchem-2615	454	5	;	;	PUNCT
eurjchem-2615	454	6	bertozzi	bertozzi	NOUN
eurjchem-2615	454	7	,	,	PUNCT
eurjchem-2615	454	8	c.	c.	PROPN
eurjchem-2615	454	9	r.	r.	PROPN
eurjchem-2615	454	10	cu	cu	PROPN
eurjchem-2615	454	11	-	-	PUNCT
eurjchem-2615	454	12	free	free	ADJ
eurjchem-2615	454	13	click	click	NOUN
eurjchem-2615	454	14	cycloaddition	cycloaddition	NOUN
eurjchem-2615	454	15	reactions	reaction	NOUN
eurjchem-2615	454	16	in	in	ADP
eurjchem-2615	454	17	chemical	chemical	ADJ
eurjchem-2615	454	18	biology	biology	NOUN
eurjchem-2615	454	19	.	.	PUNCT
eurjchem-2615	455	1	chem	chem	NOUN
eurjchem-2615	455	2	.	.	PUNCT
eurjchem-2615	456	1	soc	soc	PROPN
eurjchem-2615	456	2	.	.	PUNCT
eurjchem-2615	457	1	rev	rev	PROPN
eurjchem-2615	457	2	.	.	PROPN
eurjchem-2615	457	3	2010	2010	NUM
eurjchem-2615	457	4	,	,	PUNCT
eurjchem-2615	457	5	39	39	NUM
eurjchem-2615	457	6	(	(	PUNCT
eurjchem-2615	457	7	4	4	NUM
eurjchem-2615	457	8	)	)	PUNCT
eurjchem-2615	457	9	,	,	PUNCT
eurjchem-2615	457	10	1272	1272	NUM
eurjchem-2615	457	11	.	.	PUNCT
eurjchem-2615	458	1	[	[	X
eurjchem-2615	458	2	36	36	NUM
eurjchem-2615	458	3	]	]	PUNCT
eurjchem-2615	458	4	.	.	PUNCT
eurjchem-2615	459	1	krajczyk	krajczyk	PROPN
eurjchem-2615	459	2	,	,	PUNCT
eurjchem-2615	459	3	a.	a.	NOUN
eurjchem-2615	459	4	;	;	PUNCT
eurjchem-2615	459	5	zeidler	zeidler	NOUN
eurjchem-2615	459	6	,	,	PUNCT
eurjchem-2615	459	7	j.	j.	PROPN
eurjchem-2615	459	8	;	;	PUNCT
eurjchem-2615	459	9	januszczyk	januszczyk	PROPN
eurjchem-2615	459	10	,	,	PUNCT
eurjchem-2615	459	11	p.	p.	NOUN
eurjchem-2615	459	12	;	;	PUNCT
eurjchem-2615	459	13	dawadi	dawadi	PROPN
eurjchem-2615	459	14	,	,	PUNCT
eurjchem-2615	459	15	s.	s.	PROPN
eurjchem-2615	459	16	;	;	PUNCT
eurjchem-2615	459	17	boshoff	boshoff	PROPN
eurjchem-2615	459	18	,	,	PUNCT
eurjchem-2615	459	19	h.	h.	PROPN
eurjchem-2615	459	20	i.	i.	PROPN
eurjchem-2615	459	21	;	;	PUNCT
eurjchem-2615	459	22	barry	barry	PROPN
eurjchem-2615	459	23	,	,	PUNCT
eurjchem-2615	459	24	c.	c.	PROPN
eurjchem-2615	459	25	e.	e.	PROPN
eurjchem-2615	459	26	;	;	PUNCT
eurjchem-2615	459	27	ostrowski	ostrowski	NOUN
eurjchem-2615	459	28	,	,	PUNCT
eurjchem-2615	459	29	t.	t.	PROPN
eurjchem-2615	459	30	;	;	PUNCT
eurjchem-2615	459	31	aldrich	aldrich	PROPN
eurjchem-2615	459	32	,	,	PUNCT
eurjchem-2615	459	33	c.	c.	PROPN
eurjchem-2615	459	34	c.	c.	PROPN
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eurjchem-2615	459	36	-	-	PUNCT
eurjchem-2615	459	37	aryl-8	aryl-8	NUM
eurjchem-2615	459	38	-	-	PUNCT
eurjchem-2615	459	39	aza-3	aza-3	ADJ
eurjchem-2615	459	40	-	-	PUNCT
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eurjchem-2615	459	42	analogues	analogue	NOUN
eurjchem-2615	459	43	of	of	ADP
eurjchem-2615	459	44	5′-o-[n-(salicyl)sulfamoyl]adenosine	5′-o-[n-(salicyl)sulfamoyl]adenosine	NUM
eurjchem-2615	459	45	:	:	PUNCT
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eurjchem-2615	459	47	antibiotics	antibiotic	NOUN
eurjchem-2615	459	48	that	that	PRON
eurjchem-2615	459	49	block	block	VERB
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eurjchem-2615	459	51	biosynthesis	biosynthesis	VERB
eurjchem-2615	459	52	in	in	ADP
eurjchem-2615	459	53	mycobacterium	mycobacterium	NOUN
eurjchem-2615	459	54	tuberculosis	tuberculosis	NOUN
eurjchem-2615	459	55	.	.	PUNCT
eurjchem-2615	460	1	bioorg	bioorg	PROPN
eurjchem-2615	460	2	.	.	PUNCT
eurjchem-2615	461	1	amp	amp	PROPN
eurjchem-2615	461	2	;	;	PUNCT
eurjchem-2615	461	3	med	med	PROPN
eurjchem-2615	461	4	.	.	PROPN
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eurjchem-2615	461	6	.	.	PUNCT
eurjchem-2615	462	1	2016	2016	NUM
eurjchem-2615	462	2	,	,	PUNCT
eurjchem-2615	462	3	24	24	NUM
eurjchem-2615	462	4	(	(	PUNCT
eurjchem-2615	462	5	14	14	NUM
eurjchem-2615	462	6	)	)	PUNCT
eurjchem-2615	462	7	,	,	PUNCT
eurjchem-2615	462	8	3133–3143	3133–3143	NOUN
eurjchem-2615	462	9	.	.	PUNCT
eurjchem-2615	463	1	[	[	X
eurjchem-2615	463	2	37	37	NUM
eurjchem-2615	463	3	]	]	PUNCT
eurjchem-2615	463	4	.	.	PUNCT
eurjchem-2615	463	5	hoyle	hoyle	PROPN
eurjchem-2615	463	6	,	,	PUNCT
eurjchem-2615	463	7	c.	c.	PROPN
eurjchem-2615	463	8	;	;	PUNCT
eurjchem-2615	463	9	bowman	bowman	PROPN
eurjchem-2615	463	10	,	,	PUNCT
eurjchem-2615	463	11	c.	c.	PROPN
eurjchem-2615	463	12	thiol	thiol	PROPN
eurjchem-2615	463	13	–	–	PUNCT
eurjchem-2615	463	14	ene	ene	NOUN
eurjchem-2615	463	15	click	click	VERB
eurjchem-2615	463	16	chemistry	chemistry	NOUN
eurjchem-2615	463	17	.	.	PUNCT
eurjchem-2615	464	1	angew	angew	PROPN
eurjchem-2615	464	2	.	.	PUNCT
eurjchem-2615	465	1	chem	chem	PROPN
eurjchem-2615	465	2	.	.	PUNCT
eurjchem-2615	466	1	int	int	NOUN
eurjchem-2615	466	2	.	.	PUNCT
eurjchem-2615	467	1	ed	ed	NOUN
eurjchem-2615	467	2	.	.	PROPN
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eurjchem-2615	468	2	,	,	PUNCT
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eurjchem-2615	468	4	(	(	PUNCT
eurjchem-2615	468	5	9	9	NUM
eurjchem-2615	468	6	)	)	PUNCT
eurjchem-2615	468	7	,	,	PUNCT
eurjchem-2615	468	8	1540–1573	1540–1573	NUM
eurjchem-2615	468	9	.	.	PUNCT
eurjchem-2615	469	1	[	[	X
eurjchem-2615	469	2	38	38	NUM
eurjchem-2615	469	3	]	]	PUNCT
eurjchem-2615	469	4	.	.	PUNCT
eurjchem-2615	470	1	lü	lü	PROPN
eurjchem-2615	470	2	,	,	PUNCT
eurjchem-2615	470	3	s.	s.	PROPN
eurjchem-2615	470	4	;	;	PUNCT
eurjchem-2615	470	5	wang	wang	PROPN
eurjchem-2615	470	6	,	,	PUNCT
eurjchem-2615	470	7	z.	z.	PROPN
eurjchem-2615	470	8	;	;	PUNCT
eurjchem-2615	470	9	zhu	zhu	PROPN
eurjchem-2615	470	10	,	,	PUNCT
eurjchem-2615	470	11	s.	s.	PROPN
eurjchem-2615	470	12	thiol	thiol	PROPN
eurjchem-2615	470	13	-	-	PUNCT
eurjchem-2615	470	14	yne	yne	PROPN
eurjchem-2615	470	15	click	click	VERB
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eurjchem-2615	470	18	acetylene	acetylene	NOUN
eurjchem-2615	470	19	-	-	PUNCT
eurjchem-2615	470	20	enabled	enable	VERB
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eurjchem-2615	470	22	.	.	PUNCT
eurjchem-2615	471	1	nat	nat	PROPN
eurjchem-2615	471	2	.	.	PUNCT
eurjchem-2615	472	1	commun	commun	PROPN
eurjchem-2615	472	2	.	.	PUNCT
eurjchem-2615	473	1	2022	2022	NUM
eurjchem-2615	473	2	,	,	PUNCT
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eurjchem-2615	473	4	(	(	PUNCT
eurjchem-2615	473	5	1	1	NUM
eurjchem-2615	473	6	)	)	PUNCT
eurjchem-2615	473	7	,	,	PUNCT
eurjchem-2615	473	8	https://doi.org/10.1038/s41467–022–32723–0	https://doi.org/10.1038/s41467–022–32723–0	PROPN
eurjchem-2615	473	9	.	.	PUNCT
eurjchem-2615	474	1	[	[	X
eurjchem-2615	474	2	39	39	NUM
eurjchem-2615	474	3	]	]	PUNCT
eurjchem-2615	474	4	.	.	PUNCT
eurjchem-2615	474	5	bajaj	bajaj	PROPN
eurjchem-2615	474	6	,	,	PUNCT
eurjchem-2615	474	7	a.	a.	PROPN
eurjchem-2615	474	8	o.	o.	PROPN
eurjchem-2615	474	9	;	;	PUNCT
eurjchem-2615	474	10	saraswat	saraswat	PROPN
eurjchem-2615	474	11	,	,	PUNCT
eurjchem-2615	474	12	s.	s.	PROPN
eurjchem-2615	474	13	;	;	PUNCT
eurjchem-2615	474	14	knuuttila	knuuttila	PROPN
eurjchem-2615	474	15	,	,	PUNCT
eurjchem-2615	474	16	j.	j.	PROPN
eurjchem-2615	474	17	e.	e.	PROPN
eurjchem-2615	474	18	;	;	PUNCT
eurjchem-2615	474	19	freeke	freeke	PROPN
eurjchem-2615	474	20	,	,	PUNCT
eurjchem-2615	474	21	j.	j.	PROPN
eurjchem-2615	474	22	;	;	PUNCT
eurjchem-2615	474	23	stielow	stielow	PROPN
eurjchem-2615	474	24	,	,	PUNCT
eurjchem-2615	474	25	j.	j.	PROPN
eurjchem-2615	474	26	b.	b.	PROPN
eurjchem-2615	474	27	;	;	PUNCT
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eurjchem-2615	474	38	tuberculosis	tuberculosis	NOUN
eurjchem-2615	474	39	complex	complex	ADJ
eurjchem-2615	474	40	species	specie	NOUN
eurjchem-2615	474	41	by	by	ADP
eurjchem-2615	474	42	high	high	ADJ
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eurjchem-2615	474	44	tandem	tandem	PROPN
eurjchem-2615	474	45	mass	mass	PROPN
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eurjchem-2615	474	47	.	.	PUNCT
eurjchem-2615	475	1	front	front	NOUN
eurjchem-2615	475	2	.	.	PUNCT
eurjchem-2615	476	1	cell	cell	NOUN
eurjchem-2615	476	2	.	.	PUNCT
eurjchem-2615	477	1	infect	infect	VERB
eurjchem-2615	477	2	.	.	PUNCT
eurjchem-2615	478	1	microbiol	microbiol	PROPN
eurjchem-2615	478	2	.	.	PUNCT
eurjchem-2615	479	1	2021	2021	NUM
eurjchem-2615	479	2	,	,	PUNCT
eurjchem-2615	479	3	11	11	NUM
eurjchem-2615	479	4	,	,	PUNCT
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eurjchem-2615	479	6	.	.	PUNCT
eurjchem-2615	480	1	[	[	X
eurjchem-2615	480	2	40	40	NUM
eurjchem-2615	480	3	]	]	PUNCT
eurjchem-2615	480	4	.	.	PUNCT
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eurjchem-2615	481	2	,	,	PUNCT
eurjchem-2615	481	3	r.	r.	PROPN
eurjchem-2615	481	4	s.	s.	PROPN
eurjchem-2615	481	5	;	;	PUNCT
eurjchem-2615	481	6	mariasina	mariasina	PROPN
eurjchem-2615	481	7	,	,	PUNCT
eurjchem-2615	481	8	s.	s.	PROPN
eurjchem-2615	481	9	s.	s.	PROPN
eurjchem-2615	481	10	;	;	PUNCT
eurjchem-2615	481	11	efimov	efimov	PROPN
eurjchem-2615	481	12	,	,	PUNCT
eurjchem-2615	481	13	s.	s.	PROPN
eurjchem-2615	481	14	v.	v.	PROPN
eurjchem-2615	481	15	;	;	PUNCT
eurjchem-2615	481	16	klochkov	klochkov	PROPN
eurjchem-2615	481	17	,	,	PUNCT
eurjchem-2615	481	18	v.	v.	PROPN
eurjchem-2615	481	19	v.	v.	ADP
eurjchem-2615	481	20	;	;	PUNCT
eurjchem-2615	481	21	rodina	rodina	PROPN
eurjchem-2615	481	22	,	,	PUNCT
eurjchem-2615	481	23	e.	e.	PROPN
eurjchem-2615	481	24	v.	v.	PROPN
eurjchem-2615	481	25	;	;	PUNCT
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eurjchem-2615	481	27	,	,	PUNCT
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eurjchem-2615	481	29	i.	i.	PROPN
eurjchem-2615	481	30	backbone	backbone	PROPN
eurjchem-2615	481	31	resonance	resonance	NOUN
eurjchem-2615	481	32	assignment	assignment	NOUN
eurjchem-2615	481	33	and	and	CCONJ
eurjchem-2615	481	34	dynamics	dynamic	NOUN
eurjchem-2615	481	35	of	of	ADP
eurjchem-2615	481	36	110	110	NUM
eurjchem-2615	481	37	kda	kda	NOUN
eurjchem-2615	481	38	hexameric	hexameric	PROPN
eurjchem-2615	481	39	inorganic	inorganic	ADJ
eurjchem-2615	481	40	pyrophosphatase	pyrophosphatase	NOUN
eurjchem-2615	481	41	from	from	ADP
eurjchem-2615	481	42	mycobacterium	mycobacterium	NOUN
eurjchem-2615	481	43	tuberculosis	tuberculosis	NOUN
eurjchem-2615	481	44	.	.	PUNCT
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eurjchem-2615	482	2	nmr	nmr	PROPN
eurjchem-2615	482	3	.	.	PUNCT
eurjchem-2615	483	1	assign	assign	PROPN
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eurjchem-2615	483	3	,	,	PUNCT
eurjchem-2615	483	4	14	14	NUM
eurjchem-2615	483	5	(	(	PUNCT
eurjchem-2615	483	6	2	2	NUM
eurjchem-2615	483	7	)	)	PUNCT
eurjchem-2615	483	8	,	,	PUNCT
eurjchem-2615	483	9	281	281	NUM
eurjchem-2615	483	10	–	–	PUNCT
eurjchem-2615	483	11	287	287	NUM
eurjchem-2615	483	12	.	.	PUNCT
eurjchem-2615	484	1	[	[	X
eurjchem-2615	484	2	41	41	NUM
eurjchem-2615	484	3	]	]	PUNCT
eurjchem-2615	484	4	.	.	PUNCT
eurjchem-2615	485	1	johnpasha	johnpasha	PROPN
eurjchem-2615	485	2	,	,	PUNCT
eurjchem-2615	485	3	s.	s.	PROPN
eurjchem-2615	485	4	;	;	PUNCT
eurjchem-2615	485	5	palabindela	palabindela	PROPN
eurjchem-2615	485	6	,	,	PUNCT
eurjchem-2615	485	7	r.	r.	PROPN
eurjchem-2615	485	8	;	;	PUNCT
eurjchem-2615	485	9	azam	azam	PROPN
eurjchem-2615	485	10	,	,	PUNCT
eurjchem-2615	485	11	m.	m.	NOUN
eurjchem-2615	485	12	;	;	PUNCT
eurjchem-2615	485	13	kapavarapu	kapavarapu	PROPN
eurjchem-2615	485	14	,	,	PUNCT
eurjchem-2615	485	15	r.	r.	PROPN
eurjchem-2615	485	16	;	;	PUNCT
eurjchem-2615	485	17	nasipireddy	nasipireddy	PROPN
eurjchem-2615	485	18	,	,	PUNCT
eurjchem-2615	485	19	v.	v.	PROPN
eurjchem-2615	485	20	;	;	PUNCT
eurjchem-2615	485	21	al	al	PROPN
eurjchem-2615	485	22	-	-	PUNCT
eurjchem-2615	485	23	resayes	resayes	PROPN
eurjchem-2615	485	24	,	,	PUNCT
eurjchem-2615	485	25	s.	s.	PROPN
eurjchem-2615	485	26	i.	i.	PROPN
eurjchem-2615	485	27	;	;	PUNCT
eurjchem-2615	485	28	narsimha	narsimha	NOUN
eurjchem-2615	485	29	,	,	PUNCT
eurjchem-2615	485	30	s.	s.	PROPN
eurjchem-2615	485	31	synthesis	synthesis	NOUN
eurjchem-2615	485	32	and	and	CCONJ
eurjchem-2615	485	33	anti	anti	ADJ
eurjchem-2615	485	34	-	-	ADJ
eurjchem-2615	485	35	breast	breast	ADJ
eurjchem-2615	485	36	cancer	cancer	NOUN
eurjchem-2615	485	37	evaluation	evaluation	NOUN
eurjchem-2615	485	38	of	of	ADP
eurjchem-2615	485	39	fused	fuse	VERB
eurjchem-2615	485	40	imidazole	imidazole	NOUN
eurjchem-2615	485	41	-	-	PUNCT
eurjchem-2615	485	42	imidazo[1,2	imidazo[1,2	NOUN
eurjchem-2615	485	43	-	-	PUNCT
eurjchem-2615	485	44	c][1,2,3]triazoles	c][1,2,3]triazole	NOUN
eurjchem-2615	485	45	:	:	PUNCT
eurjchem-2615	485	46	peg-400	peg-400	NOUN
eurjchem-2615	485	47	mediated	mediate	VERB
eurjchem-2615	485	48	one	one	NUM
eurjchem-2615	485	49	-	-	PUNCT
eurjchem-2615	485	50	pot	pot	NOUN
eurjchem-2615	485	51	reaction	reaction	NOUN
eurjchem-2615	485	52	under	under	ADP
eurjchem-2615	485	53	ultrasonic	ultrasonic	ADJ
eurjchem-2615	485	54	irradiation	irradiation	NOUN
eurjchem-2615	485	55	.	.	PUNCT
eurjchem-2615	486	1	j.	j.	PROPN
eurjchem-2615	486	2	mol	mol	PROPN
eurjchem-2615	486	3	.	.	PROPN
eurjchem-2615	486	4	struct	struct	NOUN
eurjchem-2615	486	5	.	.	PUNCT
eurjchem-2615	487	1	2024	2024	NUM
eurjchem-2615	487	2	,	,	PUNCT
eurjchem-2615	487	3	1312	1312	NUM
eurjchem-2615	487	4	,	,	PUNCT
eurjchem-2615	487	5	138440	138440	NUM
eurjchem-2615	487	6	.	.	PUNCT
eurjchem-2615	488	1	[	[	X
eurjchem-2615	488	2	42	42	NUM
eurjchem-2615	488	3	]	]	PUNCT
eurjchem-2615	488	4	.	.	PUNCT
eurjchem-2615	489	1	brozyna	brozyna	PROPN
eurjchem-2615	489	2	-	-	PUNCT
eurjchem-2615	489	3	heredia	heredia	PROPN
eurjchem-2615	489	4	,	,	PUNCT
eurjchem-2615	489	5	i.	i.	PROPN
eurjchem-2615	489	6	y.	y.	PROPN
eurjchem-2615	489	7	;	;	PUNCT
eurjchem-2615	489	8	ganoza	ganoza	NOUN
eurjchem-2615	489	9	-	-	PUNCT
eurjchem-2615	489	10	yupanqui	yupanqui	NOUN
eurjchem-2615	489	11	,	,	PUNCT
eurjchem-2615	489	12	m.	m.	NOUN
eurjchem-2615	489	13	l.	l.	PROPN
eurjchem-2615	489	14	;	;	PUNCT
eurjchem-2615	489	15	moreno	moreno	PROPN
eurjchem-2615	489	16	-	-	PUNCT
eurjchem-2615	489	17	exebio	exebio	PROPN
eurjchem-2615	489	18	,	,	PUNCT
eurjchem-2615	489	19	l.	l.	PROPN
eurjchem-2615	489	20	;	;	PUNCT
eurjchem-2615	489	21	dos	dos	PROPN
eurjchem-2615	489	22	santos	santos	PROPN
eurjchem-2615	489	23	,	,	PUNCT
eurjchem-2615	489	24	j.	j.	PROPN
eurjchem-2615	489	25	l.	l.	PROPN
eurjchem-2615	489	26	chromatographic	chromatographic	ADJ
eurjchem-2615	489	27	methods	method	NOUN
eurjchem-2615	489	28	for	for	ADP
eurjchem-2615	489	29	the	the	DET
eurjchem-2615	489	30	determination	determination	NOUN
eurjchem-2615	489	31	of	of	ADP
eurjchem-2615	489	32	rifampicin	rifampicin	NOUN
eurjchem-2615	489	33	,	,	PUNCT
eurjchem-2615	489	34	isoniazid	isoniazid	NOUN
eurjchem-2615	489	35	,	,	PUNCT
eurjchem-2615	489	36	pyrazinamide	pyrazinamide	NOUN
eurjchem-2615	489	37	,	,	PUNCT
eurjchem-2615	489	38	ethambutol	ethambutol	ADJ
eurjchem-2615	489	39	,	,	PUNCT
eurjchem-2615	489	40	and	and	CCONJ
eurjchem-2615	489	41	main	main	ADJ
eurjchem-2615	489	42	metabolites	metabolite	NOUN
eurjchem-2615	489	43	in	in	ADP
eurjchem-2615	489	44	biological	biological	ADJ
eurjchem-2615	489	45	samples	sample	NOUN
eurjchem-2615	489	46	:	:	PUNCT
eurjchem-2615	489	47	a	a	DET
eurjchem-2615	489	48	review	review	NOUN
eurjchem-2615	489	49	.	.	PUNCT
eurjchem-2615	490	1	crit	crit	PROPN
eurjchem-2615	490	2	.	.	PUNCT
eurjchem-2615	491	1	rev	rev	PROPN
eurjchem-2615	491	2	.	.	PROPN
eurjchem-2615	491	3	anal	anal	PROPN
eurjchem-2615	491	4	.	.	PUNCT
eurjchem-2615	491	5	chem	chem	PROPN
eurjchem-2615	491	6	.	.	PUNCT
eurjchem-2615	492	1	2022	2022	NUM
eurjchem-2615	492	2	,	,	PUNCT
eurjchem-2615	492	3	54	54	NUM
eurjchem-2615	492	4	(	(	PUNCT
eurjchem-2615	492	5	7	7	NUM
eurjchem-2615	492	6	)	)	PUNCT
eurjchem-2615	492	7	,	,	PUNCT
eurjchem-2615	492	8	1971–1986	1971–1986	NUM
eurjchem-2615	492	9	.	.	PUNCT
eurjchem-2615	493	1	[	[	X
eurjchem-2615	493	2	43	43	NUM
eurjchem-2615	493	3	]	]	PUNCT
eurjchem-2615	493	4	.	.	PUNCT
eurjchem-2615	494	1	peyton	peyton	PROPN
eurjchem-2615	494	2	,	,	PUNCT
eurjchem-2615	494	3	l.	l.	PROPN
eurjchem-2615	494	4	;	;	PUNCT
eurjchem-2615	494	5	gallagher	gallagher	PROPN
eurjchem-2615	494	6	,	,	PUNCT
eurjchem-2615	494	7	s.	s.	PROPN
eurjchem-2615	494	8	;	;	PUNCT
eurjchem-2615	494	9	hashemzadeh	hashemzadeh	NOUN
eurjchem-2615	494	10	,	,	PUNCT
eurjchem-2615	494	11	m.	m.	NOUN
eurjchem-2615	494	12	triazole	triazole	NOUN
eurjchem-2615	494	13	antifungals	antifungal	NOUN
eurjchem-2615	494	14	:	:	PUNCT
eurjchem-2615	494	15	a	a	DET
eurjchem-2615	494	16	review	review	NOUN
eurjchem-2615	494	17	.	.	PUNCT
eurjchem-2615	495	1	drugs	drug	NOUN
eurjchem-2615	495	2	today	today	NOUN
eurjchem-2615	495	3	2015	2015	NUM
eurjchem-2615	495	4	,	,	PUNCT
eurjchem-2615	495	5	51	51	NUM
eurjchem-2615	495	6	(	(	PUNCT
eurjchem-2615	495	7	12	12	NUM
eurjchem-2615	495	8	)	)	PUNCT
eurjchem-2615	495	9	,	,	PUNCT
eurjchem-2615	495	10	705	705	NUM
eurjchem-2615	495	11	.	.	PUNCT
eurjchem-2615	496	1	[	[	X
eurjchem-2615	496	2	44	44	NUM
eurjchem-2615	496	3	]	]	PUNCT
eurjchem-2615	496	4	.	.	PUNCT
eurjchem-2615	497	1	kaur	kaur	PROPN
eurjchem-2615	497	2	,	,	PUNCT
eurjchem-2615	497	3	r.	r.	PROPN
eurjchem-2615	497	4	;	;	PUNCT
eurjchem-2615	497	5	ranjan	ranjan	PROPN
eurjchem-2615	497	6	dwivedi	dwivedi	PROPN
eurjchem-2615	497	7	,	,	PUNCT
eurjchem-2615	497	8	a.	a.	PROPN
eurjchem-2615	497	9	;	;	PUNCT
eurjchem-2615	497	10	kumar	kumar	PROPN
eurjchem-2615	497	11	,	,	PUNCT
eurjchem-2615	497	12	b.	b.	PROPN
eurjchem-2615	497	13	;	;	PUNCT
eurjchem-2615	497	14	kumar	kumar	PROPN
eurjchem-2615	497	15	,	,	PUNCT
eurjchem-2615	497	16	v.	v.	ADP
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eurjchem-2615	497	18	developments	development	NOUN
eurjchem-2615	497	19	on	on	ADP
eurjchem-2615	497	20	1,2,4	1,2,4	NUM
eurjchem-2615	497	21	-	-	PUNCT
eurjchem-2615	497	22	triazole	triazole	NOUN
eurjchem-2615	497	23	nucleus	nucleus	NOUN
eurjchem-2615	497	24	in	in	ADP
eurjchem-2615	497	25	anticancer	anticancer	NOUN
eurjchem-2615	497	26	compounds	compound	VERB
eurjchem-2615	497	27	:	:	PUNCT
eurjchem-2615	497	28	a	a	DET
eurjchem-2615	497	29	review	review	NOUN
eurjchem-2615	497	30	.	.	PUNCT
eurjchem-2615	498	1	acamc	acamc	PROPN
eurjchem-2615	498	2	.	.	PROPN
eurjchem-2615	499	1	2016	2016	NUM
eurjchem-2615	499	2	,	,	PUNCT
eurjchem-2615	499	3	16	16	NUM
eurjchem-2615	499	4	(	(	PUNCT
eurjchem-2615	499	5	4	4	NUM
eurjchem-2615	499	6	)	)	PUNCT
eurjchem-2615	499	7	,	,	PUNCT
eurjchem-2615	499	8	465–489	465–489	NUM
eurjchem-2615	499	9	.	.	PUNCT
eurjchem-2615	500	1	[	[	X
eurjchem-2615	500	2	45	45	NUM
eurjchem-2615	500	3	]	]	PUNCT
eurjchem-2615	500	4	.	.	PUNCT
eurjchem-2615	501	1	nagavelli	nagavelli	PROPN
eurjchem-2615	501	2	,	,	PUNCT
eurjchem-2615	501	3	v.	v.	PROPN
eurjchem-2615	501	4	r.	r.	PROPN
eurjchem-2615	501	5	;	;	PUNCT
eurjchem-2615	501	6	nukala	nukala	PROPN
eurjchem-2615	501	7	,	,	PUNCT
eurjchem-2615	501	8	s.	s.	PROPN
eurjchem-2615	501	9	k.	k.	PROPN
eurjchem-2615	501	10	;	;	PUNCT
eurjchem-2615	501	11	narsimha	narsimha	NOUN
eurjchem-2615	501	12	,	,	PUNCT
eurjchem-2615	501	13	s.	s.	PROPN
eurjchem-2615	501	14	;	;	PUNCT
eurjchem-2615	501	15	battula	battula	PROPN
eurjchem-2615	501	16	,	,	PUNCT
eurjchem-2615	501	17	k.	k.	PROPN
eurjchem-2615	501	18	s.	s.	PROPN
eurjchem-2615	501	19	;	;	PUNCT
eurjchem-2615	501	20	tangeda	tangeda	PROPN
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eurjchem-2615	501	22	s.	s.	PROPN
eurjchem-2615	501	23	j.	j.	PROPN
eurjchem-2615	501	24	;	;	PUNCT
eurjchem-2615	501	25	reddy	reddy	PROPN
eurjchem-2615	501	26	,	,	PUNCT
eurjchem-2615	501	27	y.	y.	PROPN
eurjchem-2615	501	28	n.	n.	PROPN
eurjchem-2615	501	29	synthesis	synthesis	NOUN
eurjchem-2615	501	30	,	,	PUNCT
eurjchem-2615	501	31	characterization	characterization	NOUN
eurjchem-2615	501	32	and	and	CCONJ
eurjchem-2615	501	33	biological	biological	ADJ
eurjchem-2615	501	34	evaluation	evaluation	NOUN
eurjchem-2615	501	35	of	of	ADP
eurjchem-2615	501	36	7substituted4-((1	7substituted4-((1	NUM
eurjchem-2615	501	37	-	-	PUNCT
eurjchem-2615	501	38	aryl-1h-1,2,3	aryl-1h-1,2,3	ADJ
eurjchem-2615	501	39	-	-	PUNCT
eurjchem-2615	501	40	triazol-4	triazol-4	NUM
eurjchem-2615	501	41	-	-	PUNCT
eurjchem-2615	501	42	yl	yl	NOUN
eurjchem-2615	501	43	)	)	PUNCT
eurjchem-2615	501	44	methyl)-2h	methyl)-2h	NOUN
eurjchem-2615	501	45	-	-	PUNCT
eurjchem-2615	501	46	benzo[b	benzo[b	NOUN
eurjchem-2615	501	47	]	]	PUNCT
eurjchem-2615	502	1	[	[	X
eurjchem-2615	502	2	1,4]oxazin3(4h)-ones	1,4]oxazin3(4h)-ones	NUM
eurjchem-2615	502	3	as	as	ADP
eurjchem-2615	502	4	anticancer	anticancer	NOUN
eurjchem-2615	502	5	agents	agent	NOUN
eurjchem-2615	502	6	.	.	PUNCT
eurjchem-2615	503	1	med	med	PROPN
eurjchem-2615	503	2	.	.	PROPN
eurjchem-2615	503	3	chem	chem	PROPN
eurjchem-2615	503	4	.	.	PUNCT
eurjchem-2615	504	1	res	re	NOUN
eurjchem-2615	504	2	.	.	PROPN
eurjchem-2615	504	3	2016	2016	NUM
eurjchem-2615	504	4	,	,	PUNCT
eurjchem-2615	504	5	25	25	NUM
eurjchem-2615	504	6	(	(	PUNCT
eurjchem-2615	504	7	9	9	NUM
eurjchem-2615	504	8	)	)	PUNCT
eurjchem-2615	504	9	,	,	PUNCT
eurjchem-2615	504	10	1781–1793	1781–1793	NUM
eurjchem-2615	504	11	.	.	PUNCT
eurjchem-2615	505	1	[	[	X
eurjchem-2615	505	2	46	46	NUM
eurjchem-2615	505	3	]	]	PUNCT
eurjchem-2615	505	4	.	.	PUNCT
eurjchem-2615	506	1	narsimha	narsimha	NOUN
eurjchem-2615	506	2	,	,	PUNCT
eurjchem-2615	506	3	s.	s.	PROPN
eurjchem-2615	506	4	;	;	PUNCT
eurjchem-2615	506	5	satheesh	satheesh	PROPN
eurjchem-2615	506	6	kumar	kumar	PROPN
eurjchem-2615	506	7	,	,	PUNCT
eurjchem-2615	506	8	n.	n.	PROPN
eurjchem-2615	506	9	;	;	PUNCT
eurjchem-2615	506	10	kumara	kumara	PROPN
eurjchem-2615	506	11	swamy	swamy	PROPN
eurjchem-2615	506	12	,	,	PUNCT
eurjchem-2615	506	13	b.	b.	PROPN
eurjchem-2615	506	14	;	;	PUNCT
eurjchem-2615	506	15	vasudeva	vasudeva	PROPN
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eurjchem-2615	506	17	,	,	PUNCT
eurjchem-2615	506	18	n.	n.	PROPN
eurjchem-2615	506	19	;	;	PUNCT
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eurjchem-2615	506	22	,	,	PUNCT
eurjchem-2615	506	23	s.	s.	PROPN
eurjchem-2615	506	24	;	;	PUNCT
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eurjchem-2615	506	28	m.	m.	NOUN
eurjchem-2615	506	29	indole-2	indole-2	NUM
eurjchem-2615	506	30	-	-	PUNCT
eurjchem-2615	506	31	carboxylic	carboxylic	ADJ
eurjchem-2615	506	32	acid	acid	NOUN
eurjchem-2615	506	33	derived	derive	VERB
eurjchem-2615	506	34	mono	mono	NOUN
eurjchem-2615	506	35	and	and	CCONJ
eurjchem-2615	506	36	bis	bis	ADJ
eurjchem-2615	506	37	1,4	1,4	ADV
eurjchem-2615	506	38	-	-	PUNCT
eurjchem-2615	506	39	disubstituted	disubstitute	VERB
eurjchem-2615	506	40	1,2,3	1,2,3	NUM
eurjchem-2615	506	41	-	-	PUNCT
eurjchem-2615	506	42	triazoles	triazole	NOUN
eurjchem-2615	506	43	:	:	PUNCT
eurjchem-2615	506	44	synthesis	synthesis	NOUN
eurjchem-2615	506	45	,	,	PUNCT
eurjchem-2615	506	46	characterization	characterization	NOUN
eurjchem-2615	506	47	and	and	CCONJ
eurjchem-2615	506	48	evaluation	evaluation	NOUN
eurjchem-2615	506	49	of	of	ADP
eurjchem-2615	506	50	anticancer	anticancer	NOUN
eurjchem-2615	506	51	,	,	PUNCT
eurjchem-2615	506	52	antibacterial	antibacterial	ADJ
eurjchem-2615	506	53	,	,	PUNCT
eurjchem-2615	506	54	and	and	CCONJ
eurjchem-2615	506	55	dnacleavage	dnacleavage	NOUN
eurjchem-2615	506	56	activities	activity	NOUN
eurjchem-2615	506	57	.	.	PUNCT
eurjchem-2615	507	1	bioorg	bioorg	PROPN
eurjchem-2615	507	2	.	.	PUNCT
eurjchem-2615	508	1	amp	amp	PROPN
eurjchem-2615	508	2	;	;	PUNCT
eurjchem-2615	508	3	med	med	PROPN
eurjchem-2615	508	4	.	.	PROPN
eurjchem-2615	508	5	chem	chem	PROPN
eurjchem-2615	508	6	.	.	PUNCT
eurjchem-2615	509	1	lett	lett	PROPN
eurjchem-2615	509	2	.	.	PROPN
eurjchem-2615	510	1	2016	2016	NUM
eurjchem-2615	510	2	,	,	PUNCT
eurjchem-2615	510	3	26	26	NUM
eurjchem-2615	510	4	(	(	PUNCT
eurjchem-2615	510	5	6	6	NUM
eurjchem-2615	510	6	)	)	PUNCT
eurjchem-2615	510	7	,	,	PUNCT
eurjchem-2615	510	8	1639	1639	NUM
eurjchem-2615	510	9	–	–	PUNCT
eurjchem-2615	510	10	1644	1644	NUM
eurjchem-2615	510	11	.	.	PUNCT
eurjchem-2615	511	1	[	[	X
eurjchem-2615	511	2	47	47	NUM
eurjchem-2615	511	3	]	]	PUNCT
eurjchem-2615	511	4	.	.	PUNCT
eurjchem-2615	512	1	zhang	zhang	PROPN
eurjchem-2615	512	2	,	,	PUNCT
eurjchem-2615	512	3	s.	s.	PROPN
eurjchem-2615	512	4	;	;	PUNCT
eurjchem-2615	512	5	xu	xu	PROPN
eurjchem-2615	512	6	,	,	PUNCT
eurjchem-2615	512	7	z.	z.	PROPN
eurjchem-2615	512	8	;	;	PUNCT
eurjchem-2615	512	9	gao	gao	PROPN
eurjchem-2615	512	10	,	,	PUNCT
eurjchem-2615	512	11	c.	c.	PROPN
eurjchem-2615	512	12	;	;	PUNCT
eurjchem-2615	512	13	ren	ren	PROPN
eurjchem-2615	512	14	,	,	PUNCT
eurjchem-2615	512	15	q.	q.	PROPN
eurjchem-2615	512	16	;	;	PUNCT
eurjchem-2615	512	17	chang	chang	PROPN
eurjchem-2615	512	18	,	,	PUNCT
eurjchem-2615	512	19	l.	l.	PROPN
eurjchem-2615	512	20	;	;	PUNCT
eurjchem-2615	512	21	lv	lv	PROPN
eurjchem-2615	512	22	,	,	PUNCT
eurjchem-2615	512	23	z.	z.	PROPN
eurjchem-2615	512	24	;	;	PUNCT
eurjchem-2615	512	25	feng	feng	PROPN
eurjchem-2615	512	26	,	,	PUNCT
eurjchem-2615	512	27	l.	l.	PROPN
eurjchem-2615	512	28	triazole	triazole	PROPN
eurjchem-2615	512	29	derivatives	derivative	NOUN
eurjchem-2615	512	30	and	and	CCONJ
eurjchem-2615	512	31	their	their	PRON
eurjchem-2615	512	32	anti	anti	ADJ
eurjchem-2615	512	33	-	-	ADJ
eurjchem-2615	512	34	tubercular	tubercular	ADJ
eurjchem-2615	512	35	activity	activity	NOUN
eurjchem-2615	512	36	.	.	PUNCT
eurjchem-2615	513	1	eur	eur	PROPN
eurjchem-2615	513	2	.	.	PUNCT
eurjchem-2615	514	1	j.	j.	PROPN
eurjchem-2615	514	2	med	med	PROPN
eurjchem-2615	514	3	.	.	PROPN
eurjchem-2615	514	4	chem	chem	PROPN
eurjchem-2615	514	5	.	.	PUNCT
eurjchem-2615	515	1	2017	2017	NUM
eurjchem-2615	515	2	,	,	PUNCT
eurjchem-2615	515	3	138	138	NUM
eurjchem-2615	515	4	,	,	PUNCT
eurjchem-2615	515	5	501–513	501–513	NUM
eurjchem-2615	515	6	.	.	PUNCT
eurjchem-2615	516	1	[	[	X
eurjchem-2615	516	2	48	48	NUM
eurjchem-2615	516	3	]	]	PUNCT
eurjchem-2615	516	4	.	.	PUNCT
eurjchem-2615	517	1	zhang	zhang	PROPN
eurjchem-2615	517	2	,	,	PUNCT
eurjchem-2615	517	3	b.	b.	PROPN
eurjchem-2615	517	4	comprehensive	comprehensive	PROPN
eurjchem-2615	517	5	review	review	NOUN
eurjchem-2615	517	6	on	on	ADP
eurjchem-2615	517	7	the	the	DET
eurjchem-2615	517	8	anti	anti	ADJ
eurjchem-2615	517	9	-	-	ADJ
eurjchem-2615	517	10	bacterial	bacterial	ADJ
eurjchem-2615	517	11	activity	activity	NOUN
eurjchem-2615	517	12	of	of	ADP
eurjchem-2615	517	13	1,2,3triazole	1,2,3triazole	NUM
eurjchem-2615	517	14	hybrids	hybrid	NOUN
eurjchem-2615	517	15	.	.	PUNCT
eurjchem-2615	518	1	eur	eur	PROPN
eurjchem-2615	518	2	.	.	PUNCT
eurjchem-2615	519	1	j.	j.	PROPN
eurjchem-2615	519	2	med	med	PROPN
eurjchem-2615	519	3	.	.	PROPN
eurjchem-2615	519	4	chem	chem	PROPN
eurjchem-2615	519	5	.	.	PUNCT
eurjchem-2615	520	1	2019	2019	NUM
eurjchem-2615	520	2	,	,	PUNCT
eurjchem-2615	520	3	168	168	NUM
eurjchem-2615	520	4	,	,	PUNCT
eurjchem-2615	520	5	357–372	357–372	NUM
eurjchem-2615	520	6	.	.	PUNCT
eurjchem-2615	521	1	[	[	X
eurjchem-2615	521	2	49	49	NUM
eurjchem-2615	521	3	]	]	PUNCT
eurjchem-2615	521	4	.	.	PUNCT
eurjchem-2615	522	1	ramya	ramya	PROPN
eurjchem-2615	522	2	sucharitha	sucharitha	PROPN
eurjchem-2615	522	3	,	,	PUNCT
eurjchem-2615	522	4	e.	e.	PROPN
eurjchem-2615	522	5	;	;	PUNCT
eurjchem-2615	522	6	krishna	krishna	PROPN
eurjchem-2615	522	7	,	,	PUNCT
eurjchem-2615	522	8	t.	t.	NOUN
eurjchem-2615	522	9	m.	m.	NOUN
eurjchem-2615	522	10	;	;	PUNCT
eurjchem-2615	522	11	manchal	manchal	ADV
eurjchem-2615	522	12	,	,	PUNCT
eurjchem-2615	522	13	r.	r.	PROPN
eurjchem-2615	522	14	;	;	PUNCT
eurjchem-2615	522	15	ramesh	ramesh	PROPN
eurjchem-2615	522	16	,	,	PUNCT
eurjchem-2615	522	17	g.	g.	PROPN
eurjchem-2615	522	18	;	;	PUNCT
eurjchem-2615	522	19	narsimha	narsimha	NOUN
eurjchem-2615	522	20	,	,	PUNCT
eurjchem-2615	522	21	s.	s.	PROPN
eurjchem-2615	522	22	fused	fuse	VERB
eurjchem-2615	522	23	benzo[1,3]thiazine-1,2,3	benzo[1,3]thiazine-1,2,3	ADJ
eurjchem-2615	522	24	-	-	PUNCT
eurjchem-2615	522	25	triazole	triazole	NOUN
eurjchem-2615	522	26	hybrids	hybrid	NOUN
eurjchem-2615	522	27	:	:	PUNCT
eurjchem-2615	522	28	microwave	microwave	NOUN
eurjchem-2615	522	29	-	-	PUNCT
eurjchem-2615	522	30	assisted	assist	VERB
eurjchem-2615	522	31	one	one	NUM
eurjchem-2615	522	32	-	-	PUNCT
eurjchem-2615	522	33	pot	pot	NOUN
eurjchem-2615	522	34	synthesis	synthesis	NOUN
eurjchem-2615	522	35	,	,	PUNCT
eurjchem-2615	522	36	in	in	ADP
eurjchem-2615	522	37	vitro	vitro	X
eurjchem-2615	522	38	antibacterial	antibacterial	ADJ
eurjchem-2615	522	39	,	,	PUNCT
eurjchem-2615	522	40	antibiofilm	antibiofilm	NOUN
eurjchem-2615	522	41	,	,	PUNCT
eurjchem-2615	522	42	and	and	CCONJ
eurjchem-2615	522	43	in	in	ADP
eurjchem-2615	522	44	silico	silico	NOUN
eurjchem-2615	522	45	adme	adme	VERB
eurjchem-2615	522	46	studies	study	NOUN
eurjchem-2615	522	47	.	.	PUNCT
eurjchem-2615	523	1	bioorg	bioorg	PROPN
eurjchem-2615	523	2	.	.	PUNCT
eurjchem-2615	524	1	med	med	PROPN
eurjchem-2615	524	2	.	.	PROPN
eurjchem-2615	524	3	chem	chem	PROPN
eurjchem-2615	524	4	.	.	PUNCT
eurjchem-2615	525	1	lett	lett	PROPN
eurjchem-2615	525	2	.	.	PROPN
eurjchem-2615	525	3	2021	2021	NUM
eurjchem-2615	525	4	,	,	PUNCT
eurjchem-2615	525	5	47	47	NUM
eurjchem-2615	525	6	,	,	PUNCT
eurjchem-2615	525	7	128201	128201	NUM
eurjchem-2615	525	8	.	.	PUNCT
eurjchem-2615	526	1	[	[	X
eurjchem-2615	526	2	50	50	NUM
eurjchem-2615	526	3	]	]	PUNCT
eurjchem-2615	526	4	.	.	PUNCT
eurjchem-2615	527	1	song	song	PROPN
eurjchem-2615	527	2	,	,	PUNCT
eurjchem-2615	527	3	m.	m.	NOUN
eurjchem-2615	527	4	;	;	PUNCT
eurjchem-2615	527	5	deng	deng	PROPN
eurjchem-2615	527	6	,	,	PUNCT
eurjchem-2615	527	7	x.	x.	NOUN
eurjchem-2615	527	8	recent	recent	ADJ
eurjchem-2615	527	9	developments	development	NOUN
eurjchem-2615	527	10	on	on	ADP
eurjchem-2615	527	11	triazole	triazole	ADJ
eurjchem-2615	527	12	nucleus	nucleus	NOUN
eurjchem-2615	527	13	in	in	ADP
eurjchem-2615	527	14	anticonvulsant	anticonvulsant	ADJ
eurjchem-2615	527	15	compounds	compound	NOUN
eurjchem-2615	527	16	:	:	PUNCT
eurjchem-2615	527	17	a	a	DET
eurjchem-2615	527	18	review	review	NOUN
eurjchem-2615	527	19	.	.	PUNCT
eurjchem-2615	528	1	j.	j.	PROPN
eurjchem-2615	528	2	enzyme	enzyme	NOUN
eurjchem-2615	528	3	inhib	inhib	NOUN
eurjchem-2615	528	4	.	.	PUNCT
eurjchem-2615	529	1	med	med	PROPN
eurjchem-2615	529	2	.	.	PUNCT
eurjchem-2615	529	3	chem	chem	PROPN
eurjchem-2615	529	4	.	.	PUNCT
eurjchem-2615	530	1	2018	2018	NUM
eurjchem-2615	530	2	,	,	PUNCT
eurjchem-2615	530	3	33	33	NUM
eurjchem-2615	530	4	(	(	PUNCT
eurjchem-2615	530	5	1	1	NUM
eurjchem-2615	530	6	)	)	PUNCT
eurjchem-2615	530	7	,	,	PUNCT
eurjchem-2615	530	8	453–478	453–478	NUM
eurjchem-2615	530	9	.	.	PUNCT
eurjchem-2615	531	1	[	[	X
eurjchem-2615	531	2	51	51	NUM
eurjchem-2615	531	3	]	]	PUNCT
eurjchem-2615	531	4	.	.	PUNCT
eurjchem-2615	532	1	sambasiva	sambasiva	PROPN
eurjchem-2615	532	2	rao	rao	PROPN
eurjchem-2615	532	3	,	,	PUNCT
eurjchem-2615	532	4	p.	p.	PROPN
eurjchem-2615	532	5	;	;	PUNCT
eurjchem-2615	532	6	kurumurthy	kurumurthy	PROPN
eurjchem-2615	532	7	,	,	PUNCT
eurjchem-2615	532	8	c.	c.	NOUN
eurjchem-2615	532	9	;	;	PUNCT
eurjchem-2615	532	10	veeraswamy	veeraswamy	NOUN
eurjchem-2615	532	11	,	,	PUNCT
eurjchem-2615	532	12	b.	b.	PROPN
eurjchem-2615	532	13	;	;	PUNCT
eurjchem-2615	532	14	santhosh	santhosh	PROPN
eurjchem-2615	532	15	kumar	kumar	PROPN
eurjchem-2615	532	16	,	,	PUNCT
eurjchem-2615	532	17	g.	g.	PROPN
eurjchem-2615	532	18	;	;	PUNCT
eurjchem-2615	532	19	poornachandra	poornachandra	NOUN
eurjchem-2615	532	20	,	,	PUNCT
eurjchem-2615	532	21	y.	y.	PROPN
eurjchem-2615	532	22	;	;	PUNCT
eurjchem-2615	532	23	ganesh	ganesh	PROPN
eurjchem-2615	532	24	kumar	kumar	PROPN
eurjchem-2615	532	25	,	,	PUNCT
eurjchem-2615	532	26	c.	c.	PROPN
eurjchem-2615	532	27	;	;	PUNCT
eurjchem-2615	532	28	vasamsetti	vasamsetti	PROPN
eurjchem-2615	532	29	,	,	PUNCT
eurjchem-2615	532	30	s.	s.	PROPN
eurjchem-2615	532	31	b.	b.	PROPN
eurjchem-2615	532	32	;	;	PUNCT
eurjchem-2615	532	33	kotamraju	kotamraju	PROPN
eurjchem-2615	532	34	,	,	PUNCT
eurjchem-2615	532	35	s.	s.	PROPN
eurjchem-2615	532	36	;	;	PUNCT
eurjchem-2615	532	37	narsaiah	narsaiah	PROPN
eurjchem-2615	532	38	,	,	PUNCT
eurjchem-2615	532	39	b.	b.	NOUN
eurjchem-2615	532	40	synthesis	synthesis	NOUN
eurjchem-2615	532	41	of	of	ADP
eurjchem-2615	532	42	novel	novel	ADJ
eurjchem-2615	532	43	1,2,3	1,2,3	NUM
eurjchem-2615	532	44	-	-	PUNCT
eurjchem-2615	532	45	triazole	triazole	ADJ
eurjchem-2615	532	46	substituted	substitute	VERB
eurjchem-2615	532	47	-	-	PUNCT
eurjchem-2615	532	48	nalkyl	nalkyl	ADJ
eurjchem-2615	532	49	/	/	SYM
eurjchem-2615	532	50	aryl	aryl	NOUN
eurjchem-2615	532	51	nitrone	nitrone	NOUN
eurjchem-2615	532	52	derivatives	derivative	NOUN
eurjchem-2615	532	53	,	,	PUNCT
eurjchem-2615	532	54	their	their	PRON
eurjchem-2615	532	55	anti	anti	ADJ
eurjchem-2615	532	56	-	-	ADJ
eurjchem-2615	532	57	inflammatory	inflammatory	ADJ
eurjchem-2615	532	58	and	and	CCONJ
eurjchem-2615	532	59	anticancer	anticancer	NOUN
eurjchem-2615	532	60	activity	activity	NOUN
eurjchem-2615	532	61	.	.	PUNCT
eurjchem-2615	533	1	eur	eur	PROPN
eurjchem-2615	533	2	.	.	PUNCT
eurjchem-2615	534	1	j.	j.	PROPN
eurjchem-2615	534	2	med	med	PROPN
eurjchem-2615	534	3	.	.	PROPN
eurjchem-2615	534	4	chem	chem	PROPN
eurjchem-2615	534	5	.	.	PUNCT
eurjchem-2615	535	1	2014	2014	NUM
eurjchem-2615	535	2	,	,	PUNCT
eurjchem-2615	535	3	80	80	NUM
eurjchem-2615	535	4	,	,	PUNCT
eurjchem-2615	535	5	184–191	184–191	NUM
eurjchem-2615	535	6	.	.	PUNCT
eurjchem-2615	536	1	[	[	X
eurjchem-2615	536	2	52	52	NUM
eurjchem-2615	536	3	]	]	PUNCT
eurjchem-2615	536	4	.	.	PUNCT
eurjchem-2615	537	1	ang	ang	PROPN
eurjchem-2615	537	2	,	,	PUNCT
eurjchem-2615	537	3	c.	c.	PROPN
eurjchem-2615	537	4	w.	w.	PROPN
eurjchem-2615	537	5	;	;	PUNCT
eurjchem-2615	537	6	jarrad	jarrad	PROPN
eurjchem-2615	537	7	,	,	PUNCT
eurjchem-2615	537	8	a.	a.	NOUN
eurjchem-2615	537	9	m.	m.	NOUN
eurjchem-2615	537	10	;	;	PUNCT
eurjchem-2615	537	11	cooper	cooper	NOUN
eurjchem-2615	537	12	,	,	PUNCT
eurjchem-2615	537	13	m.	m.	NOUN
eurjchem-2615	537	14	a.	a.	PROPN
eurjchem-2615	537	15	;	;	PUNCT
eurjchem-2615	537	16	blaskovich	blaskovich	NOUN
eurjchem-2615	537	17	,	,	PUNCT
eurjchem-2615	537	18	m.	m.	NOUN
eurjchem-2615	537	19	a.	a.	NOUN
eurjchem-2615	537	20	nitroimidazoles	nitroimidazole	VERB
eurjchem-2615	537	21	:	:	PUNCT
eurjchem-2615	537	22	molecular	molecular	ADJ
eurjchem-2615	537	23	fireworks	firework	NOUN
eurjchem-2615	537	24	that	that	PRON
eurjchem-2615	537	25	combat	combat	VERB
eurjchem-2615	537	26	a	a	DET
eurjchem-2615	537	27	broad	broad	ADJ
eurjchem-2615	537	28	spectrum	spectrum	NOUN
eurjchem-2615	537	29	of	of	ADP
eurjchem-2615	537	30	infectious	infectious	ADJ
eurjchem-2615	537	31	diseases	disease	NOUN
eurjchem-2615	537	32	.	.	PUNCT
eurjchem-2615	538	1	j.	j.	PROPN
eurjchem-2615	538	2	med	med	PROPN
eurjchem-2615	538	3	.	.	PROPN
eurjchem-2615	538	4	chem	chem	PROPN
eurjchem-2615	538	5	.	.	PUNCT
eurjchem-2615	539	1	2017	2017	NUM
eurjchem-2615	539	2	,	,	PUNCT
eurjchem-2615	539	3	60	60	NUM
eurjchem-2615	539	4	(	(	PUNCT
eurjchem-2615	539	5	18	18	NUM
eurjchem-2615	539	6	)	)	PUNCT
eurjchem-2615	539	7	,	,	PUNCT
eurjchem-2615	539	8	7636–7657	7636–7657	NUM
eurjchem-2615	539	9	.	.	PUNCT
eurjchem-2615	540	1	[	[	X
eurjchem-2615	540	2	53	53	NUM
eurjchem-2615	540	3	]	]	PUNCT
eurjchem-2615	540	4	.	.	PUNCT
eurjchem-2615	541	1	munagala	munagala	PROPN
eurjchem-2615	541	2	,	,	PUNCT
eurjchem-2615	541	3	g.	g.	PROPN
eurjchem-2615	541	4	;	;	PUNCT
eurjchem-2615	541	5	yempalla	yempalla	PROPN
eurjchem-2615	541	6	,	,	PUNCT
eurjchem-2615	541	7	k.	k.	PROPN
eurjchem-2615	541	8	r.	r.	PROPN
eurjchem-2615	541	9	;	;	PUNCT
eurjchem-2615	541	10	singh	singh	PROPN
eurjchem-2615	541	11	,	,	PUNCT
eurjchem-2615	541	12	s.	s.	PROPN
eurjchem-2615	541	13	;	;	PUNCT
eurjchem-2615	541	14	sharma	sharma	PROPN
eurjchem-2615	541	15	,	,	PUNCT
eurjchem-2615	541	16	s.	s.	PROPN
eurjchem-2615	541	17	;	;	PUNCT
eurjchem-2615	541	18	kalia	kalia	NOUN
eurjchem-2615	541	19	,	,	PUNCT
eurjchem-2615	541	20	n.	n.	PROPN
eurjchem-2615	541	21	p.	p.	PROPN
eurjchem-2615	541	22	;	;	PUNCT
eurjchem-2615	541	23	rajput	rajput	PROPN
eurjchem-2615	541	24	,	,	PUNCT
eurjchem-2615	541	25	v.	v.	PROPN
eurjchem-2615	541	26	s.	s.	PROPN
eurjchem-2615	541	27	;	;	PUNCT
eurjchem-2615	541	28	kumar	kumar	PROPN
eurjchem-2615	541	29	,	,	PUNCT
eurjchem-2615	541	30	s.	s.	PROPN
eurjchem-2615	541	31	;	;	PUNCT
eurjchem-2615	541	32	sawant	sawant	PROPN
eurjchem-2615	541	33	,	,	PUNCT
eurjchem-2615	541	34	s.	s.	PROPN
eurjchem-2615	541	35	d.	d.	PROPN
eurjchem-2615	541	36	;	;	PUNCT
eurjchem-2615	541	37	khan	khan	PROPN
eurjchem-2615	541	38	,	,	PUNCT
eurjchem-2615	541	39	i.	i.	PROPN
eurjchem-2615	541	40	a.	a.	PROPN
eurjchem-2615	541	41	;	;	PUNCT
eurjchem-2615	541	42	vishwakarma	vishwakarma	PROPN
eurjchem-2615	541	43	,	,	PUNCT
eurjchem-2615	541	44	r.	r.	PROPN
eurjchem-2615	541	45	a.	a.	PROPN
eurjchem-2615	541	46	;	;	PUNCT
eurjchem-2615	541	47	singh	singh	PROPN
eurjchem-2615	541	48	,	,	PUNCT
eurjchem-2615	542	1	p.	p.	NOUN
eurjchem-2615	542	2	p.	p.	NOUN
eurjchem-2615	542	3	synthesis	synthesis	NOUN
eurjchem-2615	542	4	of	of	ADP
eurjchem-2615	542	5	new	new	ADJ
eurjchem-2615	542	6	generation	generation	NOUN
eurjchem-2615	542	7	triazolyland	triazolyland	ADJ
eurjchem-2615	542	8	isoxazolyl	isoxazolyl	ADJ
eurjchem-2615	542	9	-	-	PUNCT
eurjchem-2615	542	10	containing	contain	VERB
eurjchem-2615	542	11	6nitro-2,3	6nitro-2,3	NUM
eurjchem-2615	542	12	-	-	PUNCT
eurjchem-2615	542	13	dihydroimidazooxazoles	dihydroimidazooxazole	NOUN
eurjchem-2615	542	14	as	as	ADP
eurjchem-2615	542	15	anti	anti	ADJ
eurjchem-2615	542	16	-	-	ADJ
eurjchem-2615	542	17	tb	tb	ADJ
eurjchem-2615	542	18	agents	agent	NOUN
eurjchem-2615	542	19	:	:	PUNCT
eurjchem-2615	542	20	in	in	ADP
eurjchem-2615	542	21	vitro	vitro	X
eurjchem-2615	542	22	,	,	PUNCT
eurjchem-2615	542	23	structure	structure	NOUN
eurjchem-2615	542	24	–	–	PUNCT
eurjchem-2615	542	25	activity	activity	NOUN
eurjchem-2615	542	26	relationship	relationship	NOUN
eurjchem-2615	542	27	,	,	PUNCT
eurjchem-2615	542	28	pharmacokinetics	pharmacokinetic	NOUN
eurjchem-2615	542	29	and	and	CCONJ
eurjchem-2615	542	30	in	in	ADP
eurjchem-2615	542	31	vivo	vivo	ADJ
eurjchem-2615	542	32	evaluation	evaluation	NOUN
eurjchem-2615	542	33	.	.	PUNCT
eurjchem-2615	543	1	org	org	PROPN
eurjchem-2615	543	2	.	.	PUNCT
eurjchem-2615	543	3	biomol	biomol	PROPN
eurjchem-2615	543	4	.	.	PUNCT
eurjchem-2615	544	1	chem	chem	PROPN
eurjchem-2615	544	2	.	.	PUNCT
eurjchem-2615	545	1	2015	2015	NUM
eurjchem-2615	545	2	,	,	PUNCT
eurjchem-2615	545	3	13	13	NUM
eurjchem-2615	545	4	(	(	PUNCT
eurjchem-2615	545	5	12	12	NUM
eurjchem-2615	545	6	)	)	PUNCT
eurjchem-2615	545	7	,	,	PUNCT
eurjchem-2615	545	8	3610–3624	3610–3624	NUM
eurjchem-2615	545	9	.	.	PUNCT
eurjchem-2615	546	1	[	[	X
eurjchem-2615	546	2	54	54	NUM
eurjchem-2615	546	3	]	]	PUNCT
eurjchem-2615	546	4	.	.	PUNCT
eurjchem-2615	547	1	ramprasad	ramprasad	ADJ
eurjchem-2615	547	2	,	,	PUNCT
eurjchem-2615	547	3	j.	j.	PROPN
eurjchem-2615	547	4	;	;	PUNCT
eurjchem-2615	547	5	nayak	nayak	PROPN
eurjchem-2615	547	6	,	,	PUNCT
eurjchem-2615	547	7	n.	n.	NOUN
eurjchem-2615	547	8	;	;	PUNCT
eurjchem-2615	547	9	dalimba	dalimba	NOUN
eurjchem-2615	547	10	,	,	PUNCT
eurjchem-2615	547	11	u.	u.	PROPN
eurjchem-2615	547	12	;	;	PUNCT
eurjchem-2615	547	13	yogeeswari	yogeeswari	PROPN
eurjchem-2615	547	14	,	,	PUNCT
eurjchem-2615	547	15	p.	p.	PROPN
eurjchem-2615	547	16	;	;	PUNCT
eurjchem-2615	547	17	sriram	sriram	PROPN
eurjchem-2615	547	18	,	,	PUNCT
eurjchem-2615	547	19	d.	d.	PROPN
eurjchem-2615	547	20	onepot	onepot	VERB
eurjchem-2615	547	21	synthesis	synthesis	NOUN
eurjchem-2615	547	22	of	of	ADP
eurjchem-2615	547	23	new	new	ADJ
eurjchem-2615	547	24	triazole	triazole	NOUN
eurjchem-2615	547	25	—	—	PUNCT
eurjchem-2615	547	26	imidazo[2,1	imidazo[2,1	NOUN
eurjchem-2615	547	27	-	-	PUNCT
eurjchem-2615	547	28	b][1,3,4]thiadiazole	b][1,3,4]thiadiazole	NOUN
eurjchem-2615	547	29	hybrids	hybrid	NOUN
eurjchem-2615	547	30	via	via	ADP
eurjchem-2615	547	31	click	click	VERB
eurjchem-2615	547	32	chemistry	chemistry	NOUN
eurjchem-2615	547	33	and	and	CCONJ
eurjchem-2615	547	34	evaluation	evaluation	NOUN
eurjchem-2615	547	35	of	of	ADP
eurjchem-2615	547	36	their	their	PRON
eurjchem-2615	547	37	antitubercular	antitubercular	ADJ
eurjchem-2615	547	38	activity	activity	NOUN
eurjchem-2615	547	39	.	.	PUNCT
eurjchem-2615	548	1	bioorg	bioorg	PROPN
eurjchem-2615	548	2	.	.	PUNCT
eurjchem-2615	549	1	amp	amp	PROPN
eurjchem-2615	549	2	;	;	PUNCT
eurjchem-2615	549	3	med	med	PROPN
eurjchem-2615	549	4	.	.	PROPN
eurjchem-2615	549	5	chem	chem	PROPN
eurjchem-2615	549	6	.	.	PUNCT
eurjchem-2615	550	1	lett	lett	PROPN
eurjchem-2615	550	2	.	.	PROPN
eurjchem-2615	551	1	2015	2015	NUM
eurjchem-2615	551	2	,	,	PUNCT
eurjchem-2615	551	3	25	25	NUM
eurjchem-2615	551	4	(	(	PUNCT
eurjchem-2615	551	5	19	19	NUM
eurjchem-2615	551	6	)	)	PUNCT
eurjchem-2615	551	7	,	,	PUNCT
eurjchem-2615	551	8	4169–4173	4169–4173	NUM
eurjchem-2615	551	9	.	.	PUNCT
eurjchem-2615	552	1	[	[	X
eurjchem-2615	552	2	55	55	NUM
eurjchem-2615	552	3	]	]	PUNCT
eurjchem-2615	552	4	.	.	PUNCT
eurjchem-2615	553	1	reddyrajula	reddyrajula	NOUN
eurjchem-2615	553	2	,	,	PUNCT
eurjchem-2615	553	3	r.	r.	PROPN
eurjchem-2615	553	4	;	;	PUNCT
eurjchem-2615	553	5	dalimba	dalimba	NOUN
eurjchem-2615	553	6	,	,	PUNCT
eurjchem-2615	553	7	u.	u.	PROPN
eurjchem-2615	553	8	k.	k.	PROPN
eurjchem-2615	554	1	structural	structural	ADJ
eurjchem-2615	554	2	modification	modification	NOUN
eurjchem-2615	554	3	of	of	ADP
eurjchem-2615	554	4	zolpidem	zolpidem	PROPN
eurjchem-2615	554	5	led	lead	VERB
eurjchem-2615	554	6	to	to	PART
eurjchem-2615	554	7	potent	potent	VERB
eurjchem-2615	554	8	antimicrobial	antimicrobial	ADJ
eurjchem-2615	554	9	activity	activity	NOUN
eurjchem-2615	554	10	in	in	ADP
eurjchem-2615	554	11	imidazo[1,2	imidazo[1,2	NOUN
eurjchem-2615	554	12	-	-	PUNCT
eurjchem-2615	554	13	a]pyridine/	a]pyridine/	NOUN
eurjchem-2615	554	14	pyrimidine-1,2,3	pyrimidine-1,2,3	NOUN
eurjchem-2615	554	15	-	-	PUNCT
eurjchem-2615	554	16	triazoles	triazole	NOUN
eurjchem-2615	554	17	.	.	PUNCT
eurjchem-2615	555	1	new	new	ADJ
eurjchem-2615	555	2	j.	j.	PROPN
eurjchem-2615	555	3	chem	chem	PROPN
eurjchem-2615	555	4	.	.	PUNCT
eurjchem-2615	556	1	2019	2019	NUM
eurjchem-2615	556	2	,	,	PUNCT
eurjchem-2615	556	3	43	43	NUM
eurjchem-2615	556	4	(	(	PUNCT
eurjchem-2615	556	5	41	41	NUM
eurjchem-2615	556	6	)	)	PUNCT
eurjchem-2615	556	7	,	,	PUNCT
eurjchem-2615	556	8	16281–16299	16281–16299	NUM
eurjchem-2615	556	9	.	.	PUNCT
eurjchem-2615	557	1	[	[	X
eurjchem-2615	557	2	56	56	NUM
eurjchem-2615	557	3	]	]	PUNCT
eurjchem-2615	557	4	.	.	PUNCT
eurjchem-2615	558	1	amaroju	amaroju	PROPN
eurjchem-2615	558	2	,	,	PUNCT
eurjchem-2615	558	3	s.	s.	PROPN
eurjchem-2615	558	4	;	;	PUNCT
eurjchem-2615	558	5	kalaga	kalaga	NOUN
eurjchem-2615	558	6	,	,	PUNCT
eurjchem-2615	558	7	m.	m.	NOUN
eurjchem-2615	558	8	n.	n.	NOUN
eurjchem-2615	558	9	;	;	PUNCT
eurjchem-2615	558	10	srinivasarao	srinivasarao	PROPN
eurjchem-2615	558	11	,	,	PUNCT
eurjchem-2615	558	12	s.	s.	PROPN
eurjchem-2615	558	13	;	;	PUNCT
eurjchem-2615	558	14	napiórkowska	napiórkowska	PROPN
eurjchem-2615	558	15	,	,	PUNCT
eurjchem-2615	558	16	a.	a.	NOUN
eurjchem-2615	558	17	;	;	PUNCT
eurjchem-2615	558	18	augustynowicz	augustynowicz	NOUN
eurjchem-2615	558	19	-	-	PUNCT
eurjchem-2615	558	20	kopeć	kopeć	PROPN
eurjchem-2615	558	21	,	,	PUNCT
eurjchem-2615	558	22	e.	e.	PROPN
eurjchem-2615	558	23	;	;	PUNCT
eurjchem-2615	558	24	murugesan	murugesan	PROPN
eurjchem-2615	558	25	,	,	PUNCT
eurjchem-2615	558	26	s.	s.	PROPN
eurjchem-2615	558	27	;	;	PUNCT
eurjchem-2615	558	28	chander	chander	PROPN
eurjchem-2615	558	29	,	,	PUNCT
eurjchem-2615	558	30	s.	s.	PROPN
eurjchem-2615	558	31	;	;	PUNCT
eurjchem-2615	558	32	krishnan	krishnan	PROPN
eurjchem-2615	558	33	,	,	PUNCT
eurjchem-2615	558	34	r.	r.	PROPN
eurjchem-2615	558	35	;	;	PUNCT
eurjchem-2615	558	36	chandra	chandra	PROPN
eurjchem-2615	558	37	sekhar	sekhar	PROPN
eurjchem-2615	558	38	,	,	PUNCT
eurjchem-2615	558	39	k.	k.	PROPN
eurjchem-2615	558	40	v.	v.	ADP
eurjchem-2615	558	41	identification	identification	NOUN
eurjchem-2615	558	42	and	and	CCONJ
eurjchem-2615	558	43	development	development	NOUN
eurjchem-2615	558	44	of	of	ADP
eurjchem-2615	558	45	pyrazolo[4,3c]pyridine	pyrazolo[4,3c]pyridine	PROPN
eurjchem-2615	558	46	carboxamides	carboxamide	VERB
eurjchem-2615	558	47	as	as	ADP
eurjchem-2615	558	48	mycobacterium	mycobacterium	NOUN
eurjchem-2615	558	49	tuberculosis	tuberculosis	NOUN
eurjchem-2615	558	50	pantothenate	pantothenate	NOUN
eurjchem-2615	558	51	synthetase	synthetase	NOUN
eurjchem-2615	558	52	inhibitors	inhibitor	NOUN
eurjchem-2615	558	53	.	.	PUNCT
eurjchem-2615	559	1	new	new	ADJ
eurjchem-2615	559	2	j.	j.	PROPN
eurjchem-2615	559	3	chem	chem	PROPN
eurjchem-2615	559	4	.	.	PUNCT
eurjchem-2615	560	1	2017	2017	NUM
eurjchem-2615	560	2	,	,	PUNCT
eurjchem-2615	560	3	41	41	NUM
eurjchem-2615	560	4	(	(	PUNCT
eurjchem-2615	560	5	1	1	NUM
eurjchem-2615	560	6	)	)	PUNCT
eurjchem-2615	560	7	,	,	PUNCT
eurjchem-2615	560	8	347	347	NUM
eurjchem-2615	560	9	–	–	PUNCT
eurjchem-2615	560	10	357	357	NUM
eurjchem-2615	560	11	.	.	PUNCT
eurjchem-2615	561	1	[	[	X
eurjchem-2615	561	2	57	57	NUM
eurjchem-2615	561	3	]	]	PUNCT
eurjchem-2615	561	4	.	.	PUNCT
eurjchem-2615	562	1	bouhaoui	bouhaoui	NOUN
eurjchem-2615	562	2	,	,	PUNCT
eurjchem-2615	562	3	a.	a.	NOUN
eurjchem-2615	562	4	;	;	PUNCT
eurjchem-2615	562	5	eddahmi	eddahmi	NOUN
eurjchem-2615	562	6	,	,	PUNCT
eurjchem-2615	562	7	m.	m.	NOUN
eurjchem-2615	562	8	;	;	PUNCT
eurjchem-2615	562	9	dib	dib	NOUN
eurjchem-2615	562	10	,	,	PUNCT
eurjchem-2615	562	11	m.	m.	NOUN
eurjchem-2615	562	12	;	;	PUNCT
eurjchem-2615	562	13	khouili	khouili	NOUN
eurjchem-2615	562	14	,	,	PUNCT
eurjchem-2615	562	15	m.	m.	NOUN
eurjchem-2615	562	16	;	;	PUNCT
eurjchem-2615	562	17	aires	aires	PROPN
eurjchem-2615	562	18	,	,	PUNCT
eurjchem-2615	562	19	a.	a.	NOUN
eurjchem-2615	562	20	;	;	PUNCT
eurjchem-2615	562	21	catto	catto	NOUN
eurjchem-2615	562	22	,	,	PUNCT
eurjchem-2615	562	23	m.	m.	NOUN
eurjchem-2615	562	24	;	;	PUNCT
eurjchem-2615	562	25	bouissane	bouissane	NOUN
eurjchem-2615	562	26	,	,	PUNCT
eurjchem-2615	562	27	l.	l.	NOUN
eurjchem-2615	562	28	synthesis	synthesis	NOUN
eurjchem-2615	562	29	and	and	CCONJ
eurjchem-2615	562	30	biological	biological	ADJ
eurjchem-2615	562	31	properties	property	NOUN
eurjchem-2615	562	32	of	of	ADP
eurjchem-2615	562	33	coumarin	coumarin	NOUN
eurjchem-2615	562	34	derivatives	derivative	NOUN
eurjchem-2615	562	35	.	.	PUNCT
eurjchem-2615	563	1	a	a	DET
eurjchem-2615	563	2	review	review	NOUN
eurjchem-2615	563	3	.	.	PUNCT
eurjchem-2615	564	1	chemistry	chemistry	NOUN
eurjchem-2615	564	2	select	select	VERB
eurjchem-2615	564	3	2021	2021	NUM
eurjchem-2615	564	4	,	,	PUNCT
eurjchem-2615	564	5	6	6	NUM
eurjchem-2615	564	6	(	(	PUNCT
eurjchem-2615	564	7	24	24	NUM
eurjchem-2615	564	8	)	)	PUNCT
eurjchem-2615	564	9	,	,	PUNCT
eurjchem-2615	564	10	5848–5870	5848–5870	NUM
eurjchem-2615	564	11	.	.	PUNCT
eurjchem-2615	565	1	[	[	X
eurjchem-2615	565	2	58	58	NUM
eurjchem-2615	565	3	]	]	PUNCT
eurjchem-2615	565	4	.	.	PUNCT
eurjchem-2615	566	1	naik	naik	PROPN
eurjchem-2615	566	2	,	,	PUNCT
eurjchem-2615	566	3	r.	r.	PROPN
eurjchem-2615	566	4	j.	j.	PROPN
eurjchem-2615	566	5	;	;	PUNCT
eurjchem-2615	566	6	kulkarni	kulkarni	PROPN
eurjchem-2615	566	7	,	,	PUNCT
eurjchem-2615	566	8	m.	m.	NOUN
eurjchem-2615	566	9	v.	v.	NOUN
eurjchem-2615	566	10	;	;	PUNCT
eurjchem-2615	566	11	sreedhara	sreedhara	PROPN
eurjchem-2615	566	12	ranganath	ranganath	NOUN
eurjchem-2615	566	13	pai	pai	PROPN
eurjchem-2615	566	14	,	,	PUNCT
eurjchem-2615	566	15	k.	k.	PROPN
eurjchem-2615	566	16	;	;	PUNCT
eurjchem-2615	566	17	nayak	nayak	PROPN
eurjchem-2615	566	18	,	,	PUNCT
eurjchem-2615	566	19	p.	p.	NOUN
eurjchem-2615	566	20	g.	g.	PROPN
eurjchem-2615	566	21	click	click	VERB
eurjchem-2615	566	22	chemistry	chemistry	NOUN
eurjchem-2615	566	23	approach	approach	NOUN
eurjchem-2615	566	24	for	for	ADP
eurjchem-2615	566	25	bis	bis	ADJ
eurjchem-2615	566	26	-	-	ADJ
eurjchem-2615	566	27	chromenyl	chromenyl	ADJ
eurjchem-2615	566	28	triazole	triazole	NOUN
eurjchem-2615	566	29	hybrids	hybrid	NOUN
eurjchem-2615	566	30	and	and	CCONJ
eurjchem-2615	566	31	their	their	PRON
eurjchem-2615	566	32	antitubercular	antitubercular	ADJ
eurjchem-2615	566	33	activity	activity	NOUN
eurjchem-2615	566	34	.	.	PUNCT
eurjchem-2615	567	1	chem	chem	NOUN
eurjchem-2615	567	2	.	.	PUNCT
eurjchem-2615	568	1	biol	biol	PROPN
eurjchem-2615	568	2	.	.	PUNCT
eurjchem-2615	569	1	drug	drug	NOUN
eurjchem-2615	569	2	.	.	PUNCT
eurjchem-2615	570	1	des	des	PROPN
eurjchem-2615	570	2	.	.	PROPN
eurjchem-2615	570	3	2012	2012	NUM
eurjchem-2615	570	4	,	,	PUNCT
eurjchem-2615	570	5	80	80	NUM
eurjchem-2615	570	6	(	(	PUNCT
eurjchem-2615	570	7	4	4	NUM
eurjchem-2615	570	8	)	)	PUNCT
eurjchem-2615	570	9	,	,	PUNCT
eurjchem-2615	570	10	516	516	NUM
eurjchem-2615	570	11	–	–	PUNCT
eurjchem-2615	570	12	523	523	NUM
eurjchem-2615	570	13	.	.	PUNCT
eurjchem-2615	571	1	[	[	X
eurjchem-2615	571	2	59	59	NUM
eurjchem-2615	571	3	]	]	PUNCT
eurjchem-2615	571	4	.	.	PUNCT
eurjchem-2615	572	1	anand	anand	PROPN
eurjchem-2615	572	2	,	,	PUNCT
eurjchem-2615	572	3	a.	a.	PROPN
eurjchem-2615	572	4	;	;	PUNCT
eurjchem-2615	572	5	naik	naik	PROPN
eurjchem-2615	572	6	,	,	PUNCT
eurjchem-2615	572	7	r.	r.	PROPN
eurjchem-2615	572	8	j.	j.	PROPN
eurjchem-2615	572	9	;	;	PUNCT
eurjchem-2615	572	10	revankar	revankar	PROPN
eurjchem-2615	572	11	,	,	PUNCT
eurjchem-2615	572	12	h.	h.	PROPN
eurjchem-2615	572	13	m.	m.	PROPN
eurjchem-2615	572	14	;	;	PUNCT
eurjchem-2615	572	15	kulkarni	kulkarni	PROPN
eurjchem-2615	572	16	,	,	PUNCT
eurjchem-2615	572	17	m.	m.	NOUN
eurjchem-2615	572	18	v.	v.	PROPN
eurjchem-2615	572	19	;	;	PUNCT
eurjchem-2615	572	20	dixit	dixit	PROPN
eurjchem-2615	572	21	,	,	PUNCT
eurjchem-2615	572	22	s.	s.	PROPN
eurjchem-2615	572	23	r.	r.	PROPN
eurjchem-2615	572	24	;	;	PUNCT
eurjchem-2615	572	25	joshi	joshi	PROPN
eurjchem-2615	572	26	,	,	PUNCT
eurjchem-2615	572	27	s.	s.	PROPN
eurjchem-2615	572	28	d.	d.	PROPN
eurjchem-2615	572	29	a	a	DET
eurjchem-2615	572	30	click	click	VERB
eurjchem-2615	572	31	chemistry	chemistry	NOUN
eurjchem-2615	572	32	approach	approach	NOUN
eurjchem-2615	572	33	for	for	ADP
eurjchem-2615	572	34	the	the	DET
eurjchem-2615	572	35	synthesis	synthesis	NOUN
eurjchem-2615	572	36	of	of	ADP
eurjchem-2615	572	37	mono	mono	PROPN
eurjchem-2615	572	38	and	and	CCONJ
eurjchem-2615	572	39	bis	bis	ADJ
eurjchem-2615	572	40	aryloxy	aryloxy	PROPN
eurjchem-2615	572	41	linked	link	VERB
eurjchem-2615	572	42	coumarinyl	coumarinyl	NOUN
eurjchem-2615	572	43	triazoles	triazole	NOUN
eurjchem-2615	572	44	as	as	ADP
eurjchem-2615	572	45	anti	anti	ADJ
eurjchem-2615	572	46	-	-	ADJ
eurjchem-2615	572	47	tubercular	tubercular	ADJ
eurjchem-2615	572	48	agents	agent	NOUN
eurjchem-2615	572	49	.	.	PUNCT
eurjchem-2615	573	1	eur	eur	PROPN
eurjchem-2615	573	2	.	.	PUNCT
eurjchem-2615	574	1	j.	j.	PROPN
eurjchem-2615	574	2	med	med	PROPN
eurjchem-2615	574	3	.	.	PROPN
eurjchem-2615	574	4	chem	chem	PROPN
eurjchem-2615	574	5	.	.	PUNCT
eurjchem-2615	575	1	2015	2015	NUM
eurjchem-2615	575	2	,	,	PUNCT
eurjchem-2615	575	3	105	105	NUM
eurjchem-2615	575	4	,	,	PUNCT
eurjchem-2615	575	5	194–207	194–207	NUM
eurjchem-2615	575	6	.	.	PUNCT
eurjchem-2615	576	1	[	[	X
eurjchem-2615	576	2	60	60	NUM
eurjchem-2615	576	3	]	]	PUNCT
eurjchem-2615	576	4	.	.	PUNCT
eurjchem-2615	577	1	hu	hu	PROPN
eurjchem-2615	577	2	,	,	PUNCT
eurjchem-2615	577	3	y.	y.	PROPN
eurjchem-2615	577	4	;	;	PUNCT
eurjchem-2615	577	5	zhang	zhang	PROPN
eurjchem-2615	577	6	,	,	PUNCT
eurjchem-2615	577	7	s.	s.	PROPN
eurjchem-2615	577	8	;	;	PUNCT
eurjchem-2615	577	9	zhao	zhao	PROPN
eurjchem-2615	577	10	,	,	PUNCT
eurjchem-2615	577	11	f.	f.	PROPN
eurjchem-2615	577	12	;	;	PUNCT
eurjchem-2615	577	13	gao	gao	PROPN
eurjchem-2615	577	14	,	,	PUNCT
eurjchem-2615	577	15	c.	c.	PROPN
eurjchem-2615	577	16	;	;	PUNCT
eurjchem-2615	577	17	feng	feng	PROPN
eurjchem-2615	577	18	,	,	PUNCT
eurjchem-2615	577	19	l.	l.	PROPN
eurjchem-2615	577	20	;	;	PUNCT
eurjchem-2615	577	21	lv	lv	PROPN
eurjchem-2615	577	22	,	,	PUNCT
eurjchem-2615	577	23	z.	z.	PROPN
eurjchem-2615	577	24	;	;	PUNCT
eurjchem-2615	577	25	xu	xu	PROPN
eurjchem-2615	577	26	,	,	PUNCT
eurjchem-2615	577	27	z.	z.	PROPN
eurjchem-2615	577	28	;	;	PUNCT
eurjchem-2615	577	29	wu	wu	PROPN
eurjchem-2615	577	30	,	,	PUNCT
eurjchem-2615	577	31	x.	x.	NOUN
eurjchem-2615	577	32	isoniazid	isoniazid	PROPN
eurjchem-2615	577	33	derivatives	derivative	NOUN
eurjchem-2615	577	34	and	and	CCONJ
eurjchem-2615	577	35	their	their	PRON
eurjchem-2615	577	36	anti	anti	ADJ
eurjchem-2615	577	37	-	-	ADJ
eurjchem-2615	577	38	tubercular	tubercular	ADJ
eurjchem-2615	577	39	activity	activity	NOUN
eurjchem-2615	577	40	.	.	PUNCT
eurjchem-2615	578	1	eur	eur	PROPN
eurjchem-2615	578	2	.	.	PUNCT
eurjchem-2615	579	1	j.	j.	PROPN
eurjchem-2615	579	2	med	med	PROPN
eurjchem-2615	579	3	.	.	PROPN
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eurjchem-2615	579	5	.	.	PUNCT
eurjchem-2615	580	1	2017	2017	NUM
eurjchem-2615	580	2	,	,	PUNCT
eurjchem-2615	580	3	133	133	NUM
eurjchem-2615	580	4	,	,	PUNCT
eurjchem-2615	580	5	255–267	255–267	NUM
eurjchem-2615	580	6	.	.	PUNCT
eurjchem-2615	581	1	[	[	X
eurjchem-2615	581	2	61	61	NUM
eurjchem-2615	581	3	]	]	PUNCT
eurjchem-2615	581	4	.	.	PUNCT
eurjchem-2615	582	1	badar	badar	PROPN
eurjchem-2615	582	2	,	,	PUNCT
eurjchem-2615	582	3	a.	a.	PROPN
eurjchem-2615	582	4	d.	d.	PROPN
eurjchem-2615	582	5	;	;	PUNCT
eurjchem-2615	582	6	sulakhe	sulakhe	PROPN
eurjchem-2615	582	7	,	,	PUNCT
eurjchem-2615	582	8	s.	s.	PROPN
eurjchem-2615	582	9	m.	m.	PROPN
eurjchem-2615	582	10	;	;	PUNCT
eurjchem-2615	582	11	muluk	muluk	PROPN
eurjchem-2615	582	12	,	,	PUNCT
eurjchem-2615	582	13	m.	m.	PROPN
eurjchem-2615	582	14	b.	b.	PROPN
eurjchem-2615	582	15	;	;	PUNCT
eurjchem-2615	582	16	rehman	rehman	PROPN
eurjchem-2615	582	17	,	,	PUNCT
eurjchem-2615	582	18	n.	n.	PROPN
eurjchem-2615	582	19	n.	n.	PROPN
eurjchem-2615	582	20	;	;	PUNCT
eurjchem-2615	582	21	dixit	dixit	PROPN
eurjchem-2615	582	22	,	,	PUNCT
eurjchem-2615	582	23	p.	p.	PROPN
eurjchem-2615	582	24	p.	p.	NOUN
eurjchem-2615	582	25	;	;	PUNCT
eurjchem-2615	582	26	choudhari	choudhari	PROPN
eurjchem-2615	582	27	,	,	PUNCT
eurjchem-2615	582	28	p.	p.	PROPN
eurjchem-2615	582	29	b.	b.	PROPN
eurjchem-2615	582	30	;	;	PUNCT
eurjchem-2615	582	31	rekha	rekha	PROPN
eurjchem-2615	582	32	,	,	PUNCT
eurjchem-2615	582	33	e.	e.	PROPN
eurjchem-2615	582	34	m.	m.	PROPN
eurjchem-2615	582	35	;	;	PUNCT
eurjchem-2615	582	36	sriram	sriram	PROPN
eurjchem-2615	582	37	,	,	PUNCT
eurjchem-2615	582	38	d.	d.	PROPN
eurjchem-2615	582	39	;	;	PUNCT
eurjchem-2615	582	40	haval	haval	PROPN
eurjchem-2615	582	41	,	,	PUNCT
eurjchem-2615	582	42	k.	k.	PROPN
eurjchem-2615	583	1	p.	p.	NOUN
eurjchem-2615	583	2	synthesis	synthesis	NOUN
eurjchem-2615	583	3	of	of	ADP
eurjchem-2615	583	4	isoniazid-1,2,3	isoniazid-1,2,3	ADJ
eurjchem-2615	583	5	-	-	ADJ
eurjchem-2615	583	6	triazole	triazole	ADJ
eurjchem-2615	583	7	conjugates	conjugate	NOUN
eurjchem-2615	583	8	:	:	PUNCT
eurjchem-2615	583	9	antitubercular	antitubercular	ADJ
eurjchem-2615	583	10	,	,	PUNCT
eurjchem-2615	583	11	antimicrobial	antimicrobial	ADJ
eurjchem-2615	583	12	evaluation	evaluation	NOUN
eurjchem-2615	583	13	and	and	CCONJ
eurjchem-2615	583	14	molecular	molecular	ADJ
eurjchem-2615	583	15	docking	docking	NOUN
eurjchem-2615	583	16	study	study	NOUN
eurjchem-2615	583	17	.	.	PUNCT
eurjchem-2615	584	1	j.	j.	PROPN
eurjchem-2615	584	2	heterocyclic	heterocyclic	PROPN
eurjchem-2615	584	3	chem	chem	PROPN
eurjchem-2615	584	4	.	.	PUNCT
eurjchem-2615	585	1	2020	2020	NUM
eurjchem-2615	585	2	,	,	PUNCT
eurjchem-2615	585	3	57	57	NUM
eurjchem-2615	585	4	(	(	PUNCT
eurjchem-2615	585	5	10	10	NUM
eurjchem-2615	585	6	)	)	PUNCT
eurjchem-2615	585	7	,	,	PUNCT
eurjchem-2615	585	8	3544–3557	3544–3557	NUM
eurjchem-2615	585	9	.	.	PUNCT
eurjchem-2615	586	1	[	[	X
eurjchem-2615	586	2	62	62	NUM
eurjchem-2615	586	3	]	]	PUNCT
eurjchem-2615	586	4	.	.	PUNCT
eurjchem-2615	587	1	boechat	boechat	NOUN
eurjchem-2615	587	2	,	,	PUNCT
eurjchem-2615	587	3	n.	n.	PROPN
eurjchem-2615	587	4	;	;	PUNCT
eurjchem-2615	587	5	ferreira	ferreira	PROPN
eurjchem-2615	587	6	,	,	PUNCT
eurjchem-2615	587	7	v.	v.	PROPN
eurjchem-2615	587	8	f.	f.	PROPN
eurjchem-2615	587	9	;	;	PUNCT
eurjchem-2615	587	10	ferreira	ferreira	PROPN
eurjchem-2615	587	11	,	,	PUNCT
eurjchem-2615	587	12	s.	s.	PROPN
eurjchem-2615	587	13	b.	b.	PROPN
eurjchem-2615	587	14	;	;	PUNCT
eurjchem-2615	587	15	ferreira	ferreira	PROPN
eurjchem-2615	587	16	,	,	PUNCT
eurjchem-2615	587	17	m.	m.	PROPN
eurjchem-2615	587	18	d.	d.	PROPN
eurjchem-2615	587	19	;	;	PUNCT
eurjchem-2615	587	20	da	da	PROPN
eurjchem-2615	587	21	silva	silva	PROPN
eurjchem-2615	587	22	,	,	PUNCT
eurjchem-2615	587	23	f.	f.	PROPN
eurjchem-2615	587	24	d.	d.	PROPN
eurjchem-2615	587	25	;	;	PUNCT
eurjchem-2615	587	26	bastos	basto	NOUN
eurjchem-2615	587	27	,	,	PUNCT
eurjchem-2615	587	28	m.	m.	NOUN
eurjchem-2615	587	29	m.	m.	NOUN
eurjchem-2615	587	30	;	;	PUNCT
eurjchem-2615	587	31	costa	costa	PROPN
eurjchem-2615	587	32	,	,	PUNCT
eurjchem-2615	587	33	m.	m.	NOUN
eurjchem-2615	587	34	d.	d.	PROPN
eurjchem-2615	587	35	;	;	PUNCT
eurjchem-2615	587	36	lourenço	lourenço	PROPN
eurjchem-2615	587	37	,	,	PUNCT
eurjchem-2615	587	38	m.	m.	NOUN
eurjchem-2615	587	39	c.	c.	PROPN
eurjchem-2615	587	40	;	;	PUNCT
eurjchem-2615	587	41	pinto	pinto	NOUN
eurjchem-2615	587	42	,	,	PUNCT
eurjchem-2615	587	43	a.	a.	PROPN
eurjchem-2615	587	44	c.	c.	PROPN
eurjchem-2615	587	45	;	;	PUNCT
eurjchem-2615	587	46	krettli	krettli	PROPN
eurjchem-2615	587	47	,	,	PUNCT
eurjchem-2615	587	48	a.	a.	PROPN
eurjchem-2615	587	49	u.	u.	PROPN
eurjchem-2615	587	50	;	;	PUNCT
eurjchem-2615	587	51	aguiar	aguiar	NOUN
eurjchem-2615	587	52	,	,	PUNCT
eurjchem-2615	587	53	a.	a.	NOUN
eurjchem-2615	587	54	c.	c.	PROPN
eurjchem-2615	587	55	;	;	PUNCT
eurjchem-2615	587	56	teixeira	teixeira	PROPN
eurjchem-2615	587	57	,	,	PUNCT
eurjchem-2615	587	58	b.	b.	PROPN
eurjchem-2615	587	59	m.	m.	PROPN
eurjchem-2615	587	60	;	;	PUNCT
eurjchem-2615	587	61	da	da	PROPN
eurjchem-2615	587	62	silva	silva	PROPN
eurjchem-2615	587	63	,	,	PUNCT
eurjchem-2615	587	64	n.	n.	PROPN
eurjchem-2615	587	65	v.	v.	PROPN
eurjchem-2615	587	66	;	;	PUNCT
eurjchem-2615	587	67	martins	martin	NOUN
eurjchem-2615	587	68	,	,	PUNCT
eurjchem-2615	587	69	p.	p.	PROPN
eurjchem-2615	587	70	r.	r.	PROPN
eurjchem-2615	587	71	;	;	PUNCT
eurjchem-2615	587	72	bezerra	bezerra	PROPN
eurjchem-2615	587	73	,	,	PUNCT
eurjchem-2615	587	74	f.	f.	PROPN
eurjchem-2615	587	75	a.	a.	PROPN
eurjchem-2615	587	76	;	;	PUNCT
eurjchem-2615	587	77	camilo	camilo	PROPN
eurjchem-2615	587	78	,	,	PUNCT
eurjchem-2615	587	79	a.	a.	PROPN
eurjchem-2615	587	80	l.	l.	PROPN
eurjchem-2615	587	81	;	;	PUNCT
eurjchem-2615	587	82	da	da	PROPN
eurjchem-2615	587	83	silva	silva	PROPN
eurjchem-2615	587	84	,	,	PUNCT
eurjchem-2615	587	85	g.	g.	PROPN
eurjchem-2615	587	86	p.	p.	PROPN
eurjchem-2615	587	87	;	;	PUNCT
eurjchem-2615	587	88	costa	costa	PROPN
eurjchem-2615	587	89	,	,	PUNCT
eurjchem-2615	587	90	c.	c.	PROPN
eurjchem-2615	587	91	c.	c.	PROPN
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eurjchem-2615	587	93	1,2,3	1,2,3	NUM
eurjchem-2615	587	94	-	-	PUNCT
eurjchem-2615	587	95	triazole	triazole	ADJ
eurjchem-2615	587	96	derivatives	derivative	NOUN
eurjchem-2615	587	97	for	for	ADP
eurjchem-2615	587	98	use	use	NOUN
eurjchem-2615	587	99	against	against	ADP
eurjchem-2615	587	100	mycobacterium	mycobacterium	NOUN
eurjchem-2615	587	101	tuberculosis	tuberculosis	NOUN
eurjchem-2615	587	102	h37rv	h37rv	PROPN
eurjchem-2615	587	103	(	(	PUNCT
eurjchem-2615	587	104	atcc	atcc	NOUN
eurjchem-2615	587	105	27294	27294	NUM
eurjchem-2615	587	106	)	)	PUNCT
eurjchem-2615	587	107	strain	strain	NOUN
eurjchem-2615	587	108	.	.	PUNCT
eurjchem-2615	588	1	j.	j.	PROPN
eurjchem-2615	588	2	med	med	PROPN
eurjchem-2615	588	3	.	.	PROPN
eurjchem-2615	588	4	chem	chem	PROPN
eurjchem-2615	588	5	.	.	PUNCT
eurjchem-2615	589	1	2011	2011	NUM
eurjchem-2615	589	2	,	,	PUNCT
eurjchem-2615	589	3	54	54	NUM
eurjchem-2615	589	4	(	(	PUNCT
eurjchem-2615	589	5	17	17	NUM
eurjchem-2615	589	6	)	)	PUNCT
eurjchem-2615	589	7	,	,	PUNCT
eurjchem-2615	589	8	5988–5999	5988–5999	NUM
eurjchem-2615	589	9	.	.	PUNCT
eurjchem-2615	590	1	[	[	X
eurjchem-2615	590	2	63	63	NUM
eurjchem-2615	590	3	]	]	PUNCT
eurjchem-2615	590	4	.	.	PUNCT
eurjchem-2615	591	1	patil	patil	PROPN
eurjchem-2615	591	2	,	,	PUNCT
eurjchem-2615	591	3	p.	p.	PROPN
eurjchem-2615	591	4	s.	s.	PROPN
eurjchem-2615	591	5	;	;	PUNCT
eurjchem-2615	591	6	kasare	kasare	PROPN
eurjchem-2615	591	7	,	,	PUNCT
eurjchem-2615	591	8	s.	s.	PROPN
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eurjchem-2615	591	10	;	;	PUNCT
eurjchem-2615	591	11	haval	haval	PROPN
eurjchem-2615	591	12	,	,	PUNCT
eurjchem-2615	591	13	n.	n.	PROPN
eurjchem-2615	591	14	b.	b.	PROPN
eurjchem-2615	591	15	;	;	PUNCT
eurjchem-2615	591	16	khedkar	khedkar	PROPN
eurjchem-2615	591	17	,	,	PUNCT
eurjchem-2615	591	18	v.	v.	ADP
eurjchem-2615	591	19	m.	m.	NOUN
eurjchem-2615	591	20	;	;	PUNCT
eurjchem-2615	591	21	dixit	dixit	PROPN
eurjchem-2615	591	22	,	,	PUNCT
eurjchem-2615	591	23	p.	p.	PROPN
eurjchem-2615	591	24	p.	p.	PROPN
eurjchem-2615	591	25	;	;	PUNCT
eurjchem-2615	591	26	rekha	rekha	PROPN
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eurjchem-2615	591	30	;	;	PUNCT
eurjchem-2615	591	31	sriram	sriram	PROPN
eurjchem-2615	591	32	,	,	PUNCT
eurjchem-2615	591	33	d.	d.	PROPN
eurjchem-2615	591	34	;	;	PUNCT
eurjchem-2615	591	35	haval	haval	PROPN
eurjchem-2615	591	36	,	,	PUNCT
eurjchem-2615	591	37	k.	k.	PROPN
eurjchem-2615	592	1	p.	p.	PROPN
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eurjchem-2615	592	3	isoniazid	isoniazid	NOUN
eurjchem-2615	592	4	embedded	embed	VERB
eurjchem-2615	592	5	triazole	triazole	ADJ
eurjchem-2615	592	6	derivatives	derivative	NOUN
eurjchem-2615	592	7	:	:	PUNCT
eurjchem-2615	592	8	synthesis	synthesis	NOUN
eurjchem-2615	592	9	,	,	PUNCT
eurjchem-2615	592	10	antitubercular	antitubercular	ADJ
eurjchem-2615	592	11	and	and	CCONJ
eurjchem-2615	592	12	antimicrobial	antimicrobial	ADJ
eurjchem-2615	592	13	activity	activity	NOUN
eurjchem-2615	592	14	evaluation	evaluation	NOUN
eurjchem-2615	592	15	.	.	PUNCT
eurjchem-2615	593	1	bioorg	bioorg	PROPN
eurjchem-2615	593	2	.	.	PUNCT
eurjchem-2615	594	1	amp	amp	PROPN
eurjchem-2615	594	2	;	;	PUNCT
eurjchem-2615	594	3	med	med	PROPN
eurjchem-2615	594	4	.	.	PROPN
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eurjchem-2615	594	6	.	.	PUNCT
eurjchem-2615	595	1	lett	lett	PROPN
eurjchem-2615	595	2	.	.	PUNCT
eurjchem-2615	596	1	2020	2020	NUM
eurjchem-2615	596	2	,	,	PUNCT
eurjchem-2615	596	3	30	30	NUM
eurjchem-2615	596	4	(	(	PUNCT
eurjchem-2615	596	5	19	19	NUM
eurjchem-2615	596	6	)	)	PUNCT
eurjchem-2615	596	7	,	,	PUNCT
eurjchem-2615	596	8	127434	127434	NUM
eurjchem-2615	596	9	.	.	PUNCT
eurjchem-2615	597	1	[	[	X
eurjchem-2615	597	2	64	64	NUM
eurjchem-2615	597	3	]	]	PUNCT
eurjchem-2615	597	4	.	.	PUNCT
eurjchem-2615	598	1	kumar	kumar	PROPN
eurjchem-2615	598	2	,	,	PUNCT
eurjchem-2615	598	3	d.	d.	PROPN
eurjchem-2615	598	4	;	;	PUNCT
eurjchem-2615	598	5	beena	beena	PROPN
eurjchem-2615	598	6	;	;	PUNCT
eurjchem-2615	598	7	khare	khare	PROPN
eurjchem-2615	598	8	,	,	PUNCT
eurjchem-2615	598	9	g.	g.	PROPN
eurjchem-2615	598	10	;	;	PUNCT
eurjchem-2615	598	11	kidwai	kidwai	PROPN
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eurjchem-2615	598	13	s.	s.	PROPN
eurjchem-2615	598	14	;	;	PUNCT
eurjchem-2615	598	15	tyagi	tyagi	PROPN
eurjchem-2615	598	16	,	,	PUNCT
eurjchem-2615	598	17	a.	a.	PROPN
eurjchem-2615	598	18	k.	k.	PROPN
eurjchem-2615	598	19	;	;	PUNCT
eurjchem-2615	598	20	singh	singh	PROPN
eurjchem-2615	598	21	,	,	PUNCT
eurjchem-2615	598	22	r.	r.	PROPN
eurjchem-2615	598	23	;	;	PUNCT
eurjchem-2615	598	24	rawat	rawat	PROPN
eurjchem-2615	598	25	,	,	PUNCT
eurjchem-2615	598	26	d.	d.	PROPN
eurjchem-2615	598	27	s.	s.	PROPN
eurjchem-2615	598	28	synthesis	synthesis	NOUN
eurjchem-2615	598	29	of	of	ADP
eurjchem-2615	598	30	novel	novel	ADJ
eurjchem-2615	598	31	1,2,3	1,2,3	NUM
eurjchem-2615	598	32	-	-	PUNCT
eurjchem-2615	598	33	triazole	triazole	ADJ
eurjchem-2615	598	34	derivatives	derivative	NOUN
eurjchem-2615	598	35	of	of	ADP
eurjchem-2615	598	36	isoniazid	isoniazid	NOUN
eurjchem-2615	598	37	and	and	CCONJ
eurjchem-2615	598	38	their	their	PRON
eurjchem-2615	598	39	in	in	ADP
eurjchem-2615	598	40	vitro	vitro	X
eurjchem-2615	598	41	and	and	CCONJ
eurjchem-2615	598	42	in	in	ADP
eurjchem-2615	598	43	vivo	vivo	ADJ
eurjchem-2615	598	44	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	598	45	activity	activity	NOUN
eurjchem-2615	598	46	evaluation	evaluation	NOUN
eurjchem-2615	598	47	.	.	PUNCT
eurjchem-2615	599	1	eur	eur	PROPN
eurjchem-2615	599	2	.	.	PUNCT
eurjchem-2615	600	1	j.	j.	PROPN
eurjchem-2615	600	2	med	med	PROPN
eurjchem-2615	600	3	.	.	PROPN
eurjchem-2615	600	4	chem	chem	PROPN
eurjchem-2615	600	5	.	.	PUNCT
eurjchem-2615	601	1	2014	2014	NUM
eurjchem-2615	601	2	,	,	PUNCT
eurjchem-2615	601	3	81	81	NUM
eurjchem-2615	601	4	,	,	PUNCT
eurjchem-2615	601	5	301–313	301–313	NUM
eurjchem-2615	601	6	.	.	PUNCT
eurjchem-2615	602	1	[	[	X
eurjchem-2615	602	2	65	65	NUM
eurjchem-2615	602	3	]	]	PUNCT
eurjchem-2615	602	4	.	.	PUNCT
eurjchem-2615	603	1	ajani	ajani	PROPN
eurjchem-2615	603	2	,	,	PUNCT
eurjchem-2615	603	3	o.	o.	PROPN
eurjchem-2615	603	4	o.	o.	PROPN
eurjchem-2615	603	5	;	;	PUNCT
eurjchem-2615	603	6	iyaye	iyaye	NOUN
eurjchem-2615	603	7	,	,	PUNCT
eurjchem-2615	603	8	k.	k.	PROPN
eurjchem-2615	603	9	t.	t.	PROPN
eurjchem-2615	603	10	;	;	PUNCT
eurjchem-2615	603	11	ademosun	ademosun	PROPN
eurjchem-2615	603	12	,	,	PUNCT
eurjchem-2615	603	13	o.	o.	NOUN
eurjchem-2615	603	14	t.	t.	PROPN
eurjchem-2615	604	1	recent	recent	ADJ
eurjchem-2615	604	2	advances	advance	NOUN
eurjchem-2615	604	3	in	in	ADP
eurjchem-2615	604	4	chemistry	chemistry	NOUN
eurjchem-2615	604	5	and	and	CCONJ
eurjchem-2615	604	6	therapeutic	therapeutic	ADJ
eurjchem-2615	604	7	potential	potential	NOUN
eurjchem-2615	604	8	of	of	ADP
eurjchem-2615	604	9	functionalized	functionalized	ADJ
eurjchem-2615	604	10	quinoline	quinoline	NOUN
eurjchem-2615	604	11	motifs	motif	NOUN
eurjchem-2615	604	12	–	–	PUNCT
eurjchem-2615	604	13	a	a	DET
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eurjchem-2615	604	15	.	.	PUNCT
eurjchem-2615	605	1	rsc	rsc	PROPN
eurjchem-2615	605	2	adv	adv	PROPN
eurjchem-2615	605	3	.	.	PROPN
eurjchem-2615	605	4	2022	2022	NUM
eurjchem-2615	605	5	,	,	PUNCT
eurjchem-2615	605	6	12	12	NUM
eurjchem-2615	605	7	,	,	PUNCT
eurjchem-2615	605	8	18594–18614	18594–18614	NUM
eurjchem-2615	605	9	.	.	PUNCT
eurjchem-2615	606	1	[	[	X
eurjchem-2615	606	2	66	66	NUM
eurjchem-2615	606	3	]	]	PUNCT
eurjchem-2615	606	4	.	.	PUNCT
eurjchem-2615	607	1	worley	worley	PROPN
eurjchem-2615	607	2	,	,	PUNCT
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eurjchem-2615	607	4	v.	v.	PROPN
eurjchem-2615	607	5	;	;	PUNCT
eurjchem-2615	607	6	estrada	estrada	PROPN
eurjchem-2615	607	7	,	,	PUNCT
eurjchem-2615	607	8	s.	s.	PROPN
eurjchem-2615	607	9	j.	j.	PROPN
eurjchem-2615	607	10	bedaquiline	bedaquiline	PROPN
eurjchem-2615	607	11	:	:	PUNCT
eurjchem-2615	607	12	a	a	DET
eurjchem-2615	607	13	novel	novel	ADJ
eurjchem-2615	607	14	antitubercular	antitubercular	ADJ
eurjchem-2615	607	15	agent	agent	NOUN
eurjchem-2615	607	16	for	for	ADP
eurjchem-2615	607	17	the	the	DET
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eurjchem-2615	607	19	of	of	ADP
eurjchem-2615	607	20	multidrug	multidrug	NOUN
eurjchem-2615	607	21	-	-	PUNCT
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eurjchem-2615	607	23	tuberculosis	tuberculosis	NOUN
eurjchem-2615	607	24	.	.	PUNCT
eurjchem-2615	608	1	pharmacotherapy	pharmacotherapy	NOUN
eurjchem-2615	608	2	2014	2014	NUM
eurjchem-2615	608	3	,	,	PUNCT
eurjchem-2615	608	4	34	34	NUM
eurjchem-2615	608	5	(	(	PUNCT
eurjchem-2615	608	6	11	11	NUM
eurjchem-2615	608	7	)	)	PUNCT
eurjchem-2615	608	8	,	,	PUNCT
eurjchem-2615	608	9	1187–1197	1187–1197	NUM
eurjchem-2615	608	10	.	.	PUNCT
eurjchem-2615	609	1	https://doi.org/10.1038/s41467%e2%80%93022%e2%80%9332723%e2%80%930	https://doi.org/10.1038/s41467%e2%80%93022%e2%80%9332723%e2%80%930	NUM
eurjchem-2615	610	1	https://doi.org/10.3389/fcimb.2021.656880	https://doi.org/10.3389/fcimb.2021.656880	PROPN
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eurjchem-2615	610	6	/	/	SYM
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eurjchem-2615	610	11	16	16	NUM
eurjchem-2615	610	12	(	(	PUNCT
eurjchem-2615	610	13	1	1	NUM
eurjchem-2615	610	14	)	)	PUNCT
eurjchem-2615	610	15	(	(	PUNCT
eurjchem-2615	610	16	2025	2025	NUM
eurjchem-2615	610	17	)	)	PUNCT
eurjchem-2615	610	18	83	83	NUM
eurjchem-2615	610	19	-	-	SYM
eurjchem-2615	610	20	96	96	NUM
eurjchem-2615	610	21	2025	2025	NUM
eurjchem-2615	610	22	–	–	PUNCT
eurjchem-2615	610	23	european	european	ADJ
eurjchem-2615	610	24	journal	journal	NOUN
eurjchem-2615	610	25	of	of	ADP
eurjchem-2615	610	26	chemistry	chemistry	NOUN
eurjchem-2615	610	27	–	–	PUNCT
eurjchem-2615	610	28	cc	cc	NOUN
eurjchem-2615	610	29	by	by	ADP
eurjchem-2615	610	30	nc	nc	PROPN
eurjchem-2615	610	31	–	–	PUNCT
eurjchem-2615	610	32	doi	doi	NOUN
eurjchem-2615	610	33	:	:	PUNCT
eurjchem-2615	610	34	10.5155	10.5155	NUM
eurjchem-2615	610	35	/	/	SYM
eurjchem-2615	610	36	eurjchem.16.1.83	eurjchem.16.1.83	PROPN
eurjchem-2615	610	37	-	-	PUNCT
eurjchem-2615	610	38	96.2615	96.2615	NUM
eurjchem-2615	611	1	[	[	X
eurjchem-2615	611	2	67	67	NUM
eurjchem-2615	611	3	]	]	PUNCT
eurjchem-2615	611	4	.	.	PUNCT
eurjchem-2615	612	1	thomas	thomas	PROPN
eurjchem-2615	612	2	,	,	PUNCT
eurjchem-2615	612	3	k.	k.	PROPN
eurjchem-2615	612	4	;	;	PUNCT
eurjchem-2615	612	5	adhikari	adhikari	PROPN
eurjchem-2615	612	6	,	,	PUNCT
eurjchem-2615	612	7	a.	a.	NOUN
eurjchem-2615	612	8	v.	v.	PROPN
eurjchem-2615	612	9	;	;	PUNCT
eurjchem-2615	612	10	chowdhury	chowdhury	PROPN
eurjchem-2615	612	11	,	,	PUNCT
eurjchem-2615	612	12	i.	i.	PROPN
eurjchem-2615	612	13	h.	h.	PROPN
eurjchem-2615	612	14	;	;	PUNCT
eurjchem-2615	612	15	sumesh	sumesh	PROPN
eurjchem-2615	612	16	,	,	PUNCT
eurjchem-2615	612	17	e.	e.	PROPN
eurjchem-2615	612	18	;	;	PUNCT
eurjchem-2615	612	19	pal	pal	NOUN
eurjchem-2615	612	20	,	,	PUNCT
eurjchem-2615	612	21	n.	n.	PROPN
eurjchem-2615	612	22	k.	k.	PROPN
eurjchem-2615	613	1	new	new	PROPN
eurjchem-2615	613	2	quinolin-4	quinolin-4	PROPN
eurjchem-2615	613	3	-	-	PUNCT
eurjchem-2615	613	4	yl-1,2,3	yl-1,2,3	ADJ
eurjchem-2615	613	5	-	-	PUNCT
eurjchem-2615	613	6	triazoles	triazoles	NOUN
eurjchem-2615	613	7	carrying	carrying	NOUN
eurjchem-2615	613	8	amides	amide	NOUN
eurjchem-2615	613	9	,	,	PUNCT
eurjchem-2615	613	10	sulphonamides	sulphonamide	NOUN
eurjchem-2615	613	11	and	and	CCONJ
eurjchem-2615	613	12	amidopiperazines	amidopiperazine	NOUN
eurjchem-2615	613	13	as	as	ADP
eurjchem-2615	613	14	potential	potential	ADJ
eurjchem-2615	613	15	antitubercular	antitubercular	ADJ
eurjchem-2615	613	16	agents	agent	NOUN
eurjchem-2615	613	17	.	.	PUNCT
eurjchem-2615	614	1	eur	eur	PROPN
eurjchem-2615	614	2	.	.	PUNCT
eurjchem-2615	615	1	j.	j.	PROPN
eurjchem-2615	615	2	med	med	PROPN
eurjchem-2615	615	3	.	.	PROPN
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eurjchem-2615	615	5	.	.	PUNCT
eurjchem-2615	616	1	2011	2011	NUM
eurjchem-2615	616	2	,	,	PUNCT
eurjchem-2615	616	3	46	46	NUM
eurjchem-2615	616	4	(	(	PUNCT
eurjchem-2615	616	5	6	6	NUM
eurjchem-2615	616	6	)	)	PUNCT
eurjchem-2615	616	7	,	,	PUNCT
eurjchem-2615	616	8	2503–2512	2503–2512	NUM
eurjchem-2615	616	9	.	.	PUNCT
eurjchem-2615	617	1	[	[	X
eurjchem-2615	617	2	68	68	NUM
eurjchem-2615	617	3	]	]	SYM
eurjchem-2615	617	4	.	.	PUNCT
eurjchem-2615	618	1	marvadi	marvadi	PROPN
eurjchem-2615	618	2	,	,	PUNCT
eurjchem-2615	618	3	s.	s.	PROPN
eurjchem-2615	618	4	k.	k.	PROPN
eurjchem-2615	618	5	;	;	PUNCT
eurjchem-2615	618	6	krishna	krishna	PROPN
eurjchem-2615	618	7	,	,	PUNCT
eurjchem-2615	618	8	v.	v.	PROPN
eurjchem-2615	618	9	s.	s.	PROPN
eurjchem-2615	618	10	;	;	PUNCT
eurjchem-2615	618	11	sriram	sriram	PROPN
eurjchem-2615	618	12	,	,	PUNCT
eurjchem-2615	618	13	d.	d.	PROPN
eurjchem-2615	618	14	;	;	PUNCT
eurjchem-2615	618	15	kantevari	kantevari	PROPN
eurjchem-2615	618	16	,	,	PUNCT
eurjchem-2615	618	17	s.	s.	PROPN
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eurjchem-2615	618	19	and	and	CCONJ
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eurjchem-2615	618	24	1,2,3	1,2,3	NUM
eurjchem-2615	618	25	-	-	NOUN
eurjchem-2615	618	26	triazolyldihydroquinolines	triazolyldihydroquinoline	NOUN
eurjchem-2615	618	27	as	as	ADP
eurjchem-2615	618	28	promising	promise	VERB
eurjchem-2615	618	29	antitubercular	antitubercular	ADJ
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eurjchem-2615	618	31	.	.	PUNCT
eurjchem-2615	619	1	bioorg	bioorg	PROPN
eurjchem-2615	619	2	.	.	PUNCT
eurjchem-2615	620	1	amp	amp	PROPN
eurjchem-2615	620	2	;	;	PUNCT
eurjchem-2615	620	3	med	med	PROPN
eurjchem-2615	620	4	.	.	PROPN
eurjchem-2615	620	5	chem	chem	PROPN
eurjchem-2615	620	6	.	.	PUNCT
eurjchem-2615	621	1	lett	lett	PROPN
eurjchem-2615	621	2	.	.	PROPN
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eurjchem-2615	622	2	,	,	PUNCT
eurjchem-2615	622	3	29	29	NUM
eurjchem-2615	622	4	(	(	PUNCT
eurjchem-2615	622	5	4	4	NUM
eurjchem-2615	622	6	)	)	PUNCT
eurjchem-2615	622	7	,	,	PUNCT
eurjchem-2615	622	8	529–533	529–533	NUM
eurjchem-2615	622	9	.	.	PUNCT
eurjchem-2615	623	1	[	[	X
eurjchem-2615	623	2	69	69	NUM
eurjchem-2615	623	3	]	]	SYM
eurjchem-2615	623	4	.	.	PUNCT
eurjchem-2615	624	1	pogaku	pogaku	PROPN
eurjchem-2615	624	2	,	,	PUNCT
eurjchem-2615	624	3	v.	v.	ADV
eurjchem-2615	624	4	;	;	PUNCT
eurjchem-2615	624	5	krishna	krishna	PROPN
eurjchem-2615	624	6	,	,	PUNCT
eurjchem-2615	624	7	v.	v.	PROPN
eurjchem-2615	624	8	s.	s.	PROPN
eurjchem-2615	624	9	;	;	PUNCT
eurjchem-2615	624	10	balachandran	balachandran	NOUN
eurjchem-2615	624	11	,	,	PUNCT
eurjchem-2615	624	12	c.	c.	PROPN
eurjchem-2615	624	13	;	;	PUNCT
eurjchem-2615	624	14	rangan	rangan	VERB
eurjchem-2615	624	15	,	,	PUNCT
eurjchem-2615	624	16	k.	k.	PROPN
eurjchem-2615	624	17	;	;	PUNCT
eurjchem-2615	624	18	sriram	sriram	PROPN
eurjchem-2615	624	19	,	,	PUNCT
eurjchem-2615	624	20	d.	d.	PROPN
eurjchem-2615	624	21	;	;	PUNCT
eurjchem-2615	624	22	aoki	aoki	PROPN
eurjchem-2615	624	23	,	,	PUNCT
eurjchem-2615	624	24	s.	s.	PROPN
eurjchem-2615	624	25	;	;	PUNCT
eurjchem-2615	624	26	basavoju	basavoju	PROPN
eurjchem-2615	624	27	,	,	PUNCT
eurjchem-2615	624	28	s.	s.	PROPN
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eurjchem-2615	624	30	design	design	PROPN
eurjchem-2615	624	31	and	and	CCONJ
eurjchem-2615	624	32	green	green	ADJ
eurjchem-2615	624	33	synthesis	synthesis	NOUN
eurjchem-2615	624	34	of	of	ADP
eurjchem-2615	624	35	novel	novel	ADJ
eurjchem-2615	624	36	benzotriazoloquinolinyl	benzotriazoloquinolinyl	NOUN
eurjchem-2615	624	37	spirooxindolopyrrolizidines	spirooxindolopyrrolizidine	NOUN
eurjchem-2615	624	38	:	:	PUNCT
eurjchem-2615	624	39	antimyco	antimyco	ADJ
eurjchem-2615	624	40	bacterial	bacterial	ADJ
eurjchem-2615	624	41	and	and	CCONJ
eurjchem-2615	624	42	antiproliferative	antiproliferative	ADJ
eurjchem-2615	624	43	studies	study	NOUN
eurjchem-2615	624	44	.	.	PUNCT
eurjchem-2615	625	1	new	new	ADJ
eurjchem-2615	625	2	j.	j.	PROPN
eurjchem-2615	625	3	chem	chem	PROPN
eurjchem-2615	625	4	.	.	PUNCT
eurjchem-2615	626	1	2019	2019	NUM
eurjchem-2615	626	2	,	,	PUNCT
eurjchem-2615	626	3	43	43	NUM
eurjchem-2615	626	4	(	(	PUNCT
eurjchem-2615	626	5	44	44	NUM
eurjchem-2615	626	6	)	)	PUNCT
eurjchem-2615	626	7	,	,	PUNCT
eurjchem-2615	626	8	17511–17520	17511–17520	NUM
eurjchem-2615	626	9	.	.	PUNCT
eurjchem-2615	627	1	[	[	X
eurjchem-2615	627	2	70	70	NUM
eurjchem-2615	627	3	]	]	PUNCT
eurjchem-2615	627	4	.	.	PUNCT
eurjchem-2615	628	1	shinde	shinde	PROPN
eurjchem-2615	628	2	,	,	PUNCT
eurjchem-2615	628	3	a.	a.	PROPN
eurjchem-2615	628	4	d.	d.	PROPN
eurjchem-2615	628	5	;	;	PUNCT
eurjchem-2615	628	6	nandurkar	nandurkar	PROPN
eurjchem-2615	628	7	,	,	PUNCT
eurjchem-2615	628	8	y.	y.	PROPN
eurjchem-2615	628	9	m.	m.	PROPN
eurjchem-2615	628	10	;	;	PUNCT
eurjchem-2615	628	11	bhalekar	bhalekar	PROPN
eurjchem-2615	628	12	,	,	PUNCT
eurjchem-2615	628	13	s.	s.	PROPN
eurjchem-2615	628	14	;	;	PUNCT
eurjchem-2615	628	15	walunj	walunj	PROPN
eurjchem-2615	628	16	,	,	PUNCT
eurjchem-2615	628	17	y.	y.	PROPN
eurjchem-2615	628	18	s.	s.	PROPN
eurjchem-2615	628	19	;	;	PUNCT
eurjchem-2615	628	20	ugale	ugale	PROPN
eurjchem-2615	628	21	,	,	PUNCT
eurjchem-2615	628	22	s.	s.	PROPN
eurjchem-2615	628	23	;	;	PUNCT
eurjchem-2615	628	24	ahmad	ahmad	PROPN
eurjchem-2615	628	25	,	,	PUNCT
eurjchem-2615	628	26	i.	i.	PROPN
eurjchem-2615	628	27	;	;	PUNCT
eurjchem-2615	628	28	patel	patel	PROPN
eurjchem-2615	628	29	,	,	PUNCT
eurjchem-2615	628	30	h.	h.	PROPN
eurjchem-2615	628	31	;	;	PUNCT
eurjchem-2615	628	32	chavan	chavan	PROPN
eurjchem-2615	628	33	,	,	PUNCT
eurjchem-2615	628	34	a.	a.	NOUN
eurjchem-2615	628	35	p.	p.	NOUN
eurjchem-2615	628	36	;	;	PUNCT
eurjchem-2615	628	37	mhaske	mhaske	PROPN
eurjchem-2615	628	38	,	,	PUNCT
eurjchem-2615	628	39	p.	p.	PROPN
eurjchem-2615	628	40	c.	c.	PROPN
eurjchem-2615	628	41	investigation	investigation	NOUN
eurjchem-2615	628	42	of	of	ADP
eurjchem-2615	628	43	new	new	ADJ
eurjchem-2615	628	44	1,2,3	1,2,3	NUM
eurjchem-2615	628	45	-	-	ADJ
eurjchem-2615	628	46	triazolyl	triazolyl	ADJ
eurjchem-2615	628	47	-	-	PUNCT
eurjchem-2615	628	48	quinolinyl	quinolinyl	NOUN
eurjchem-2615	628	49	-	-	PUNCT
eurjchem-2615	628	50	propan-2	propan-2	NOUN
eurjchem-2615	628	51	-	-	PUNCT
eurjchem-2615	628	52	ol	ol	ADJ
eurjchem-2615	628	53	derivatives	derivative	NOUN
eurjchem-2615	628	54	as	as	ADP
eurjchem-2615	628	55	potential	potential	ADJ
eurjchem-2615	628	56	antimicrobial	antimicrobial	ADJ
eurjchem-2615	628	57	agents	agent	NOUN
eurjchem-2615	628	58	:	:	PUNCT
eurjchem-2615	628	59	in	in	ADP
eurjchem-2615	628	60	vitro	vitro	X
eurjchem-2615	628	61	and	and	CCONJ
eurjchem-2615	628	62	in	in	ADP
eurjchem-2615	628	63	silico	silico	NOUN
eurjchem-2615	628	64	approach	approach	NOUN
eurjchem-2615	628	65	.	.	PUNCT
eurjchem-2615	629	1	j.	j.	PROPN
eurjchem-2615	629	2	biomol	biomol	PROPN
eurjchem-2615	629	3	.	.	PUNCT
eurjchem-2615	629	4	struct	struct	NOUN
eurjchem-2615	629	5	.	.	PUNCT
eurjchem-2615	630	1	dyn	dyn	NOUN
eurjchem-2615	630	2	.	.	PUNCT
eurjchem-2615	631	1	2023	2023	NUM
eurjchem-2615	631	2	,	,	PUNCT
eurjchem-2615	631	3	42	42	NUM
eurjchem-2615	631	4	(	(	PUNCT
eurjchem-2615	631	5	3	3	NUM
eurjchem-2615	631	6	)	)	PUNCT
eurjchem-2615	631	7	,	,	PUNCT
eurjchem-2615	631	8	1191–1207	1191–1207	NUM
eurjchem-2615	631	9	.	.	PUNCT
eurjchem-2615	632	1	[	[	X
eurjchem-2615	632	2	71	71	NUM
eurjchem-2615	632	3	]	]	SYM
eurjchem-2615	632	4	.	.	PUNCT
eurjchem-2615	632	5	kushawaha	kushawaha	PROPN
eurjchem-2615	632	6	,	,	PUNCT
eurjchem-2615	632	7	a.	a.	PROPN
eurjchem-2615	632	8	k.	k.	PROPN
eurjchem-2615	632	9	;	;	PUNCT
eurjchem-2615	632	10	jaiswal	jaiswal	PROPN
eurjchem-2615	632	11	,	,	PUNCT
eurjchem-2615	632	12	a.	a.	PROPN
eurjchem-2615	632	13	k.	k.	PROPN
eurjchem-2615	632	14	;	;	PUNCT
eurjchem-2615	632	15	gupta	gupta	PROPN
eurjchem-2615	632	16	,	,	PUNCT
eurjchem-2615	632	17	j.	j.	PROPN
eurjchem-2615	632	18	;	;	PUNCT
eurjchem-2615	632	19	katiyar	katiyar	PROPN
eurjchem-2615	632	20	,	,	PUNCT
eurjchem-2615	632	21	s.	s.	PROPN
eurjchem-2615	632	22	;	;	PUNCT
eurjchem-2615	632	23	ansari	ansari	PROPN
eurjchem-2615	632	24	,	,	PUNCT
eurjchem-2615	632	25	a.	a.	NOUN
eurjchem-2615	632	26	;	;	PUNCT
eurjchem-2615	632	27	bhatt	bhatt	PROPN
eurjchem-2615	632	28	,	,	PUNCT
eurjchem-2615	632	29	h.	h.	PROPN
eurjchem-2615	632	30	;	;	PUNCT
eurjchem-2615	632	31	sharma	sharma	PROPN
eurjchem-2615	632	32	,	,	PUNCT
eurjchem-2615	632	33	s.	s.	PROPN
eurjchem-2615	632	34	k.	k.	PROPN
eurjchem-2615	632	35	;	;	PUNCT
eurjchem-2615	632	36	choudhury	choudhury	PROPN
eurjchem-2615	632	37	,	,	PUNCT
eurjchem-2615	632	38	a.	a.	PROPN
eurjchem-2615	632	39	d.	d.	PROPN
eurjchem-2615	632	40	;	;	PUNCT
eurjchem-2615	632	41	bhatta	bhatta	PROPN
eurjchem-2615	632	42	,	,	PUNCT
eurjchem-2615	632	43	r.	r.	PROPN
eurjchem-2615	632	44	s.	s.	PROPN
eurjchem-2615	632	45	;	;	PUNCT
eurjchem-2615	632	46	singh	singh	PROPN
eurjchem-2615	632	47	,	,	PUNCT
eurjchem-2615	632	48	b.	b.	PROPN
eurjchem-2615	632	49	n.	n.	PROPN
eurjchem-2615	632	50	;	;	PUNCT
eurjchem-2615	632	51	sashidhara	sashidhara	NOUN
eurjchem-2615	632	52	,	,	PUNCT
eurjchem-2615	632	53	k.	k.	NOUN
eurjchem-2615	632	54	v.	v.	CCONJ
eurjchem-2615	632	55	antitubercular	antitubercular	ADJ
eurjchem-2615	632	56	evaluation	evaluation	NOUN
eurjchem-2615	632	57	of	of	ADP
eurjchem-2615	632	58	dihydropyridine	dihydropyridine	NOUN
eurjchem-2615	632	59	–	–	PUNCT
eurjchem-2615	632	60	triazole	triazole	NOUN
eurjchem-2615	632	61	conjugates	conjugate	NOUN
eurjchem-2615	632	62	:	:	PUNCT
eurjchem-2615	632	63	design	design	NOUN
eurjchem-2615	632	64	,	,	PUNCT
eurjchem-2615	632	65	synthesis	synthesis	NOUN
eurjchem-2615	632	66	,	,	PUNCT
eurjchem-2615	632	67	in	in	ADP
eurjchem-2615	632	68	vitro	vitro	X
eurjchem-2615	632	69	screening	screen	VERB
eurjchem-2615	632	70	,	,	PUNCT
eurjchem-2615	632	71	sar	sar	NOUN
eurjchem-2615	632	72	and	and	CCONJ
eurjchem-2615	632	73	in	in	ADP
eurjchem-2615	632	74	silico	silico	NOUN
eurjchem-2615	632	75	adme	adme	NOUN
eurjchem-2615	632	76	predictions	prediction	NOUN
eurjchem-2615	632	77	.	.	PUNCT
eurjchem-2615	633	1	rsc	rsc	PROPN
eurjchem-2615	633	2	.	.	PUNCT
eurjchem-2615	634	1	med	med	PROPN
eurjchem-2615	634	2	.	.	PROPN
eurjchem-2615	634	3	chem	chem	PROPN
eurjchem-2615	634	4	.	.	PUNCT
eurjchem-2615	635	1	2024	2024	NUM
eurjchem-2615	635	2	,	,	PUNCT
eurjchem-2615	635	3	15	15	NUM
eurjchem-2615	635	4	(	(	PUNCT
eurjchem-2615	635	5	8)	8)	NUM
eurjchem-2615	635	6	,	,	PUNCT
eurjchem-2615	635	7	2867–2881	2867–2881	NUM
eurjchem-2615	635	8	.	.	PUNCT
eurjchem-2615	636	1	[	[	X
eurjchem-2615	636	2	72	72	NUM
eurjchem-2615	636	3	]	]	PUNCT
eurjchem-2615	636	4	.	.	PUNCT
eurjchem-2615	637	1	lungu	lungu	PROPN
eurjchem-2615	637	2	,	,	PUNCT
eurjchem-2615	637	3	i.	i.	PROPN
eurjchem-2615	637	4	;	;	PUNCT
eurjchem-2615	637	5	moldovan	moldovan	PROPN
eurjchem-2615	637	6	,	,	PUNCT
eurjchem-2615	637	7	o.	o.	PROPN
eurjchem-2615	637	8	;	;	PUNCT
eurjchem-2615	637	9	biriș	biriș	NOUN
eurjchem-2615	637	10	,	,	PUNCT
eurjchem-2615	637	11	v.	v.	ADV
eurjchem-2615	637	12	;	;	PUNCT
eurjchem-2615	637	13	rusu	rusu	PROPN
eurjchem-2615	637	14	,	,	PUNCT
eurjchem-2615	637	15	a.	a.	NOUN
eurjchem-2615	637	16	fluoroquinolones	fluoroquinolone	NOUN
eurjchem-2615	637	17	hybrid	hybrid	ADJ
eurjchem-2615	637	18	molecules	molecule	NOUN
eurjchem-2615	637	19	as	as	ADP
eurjchem-2615	637	20	promising	promise	VERB
eurjchem-2615	637	21	antibacterial	antibacterial	ADJ
eurjchem-2615	637	22	agents	agent	NOUN
eurjchem-2615	637	23	in	in	ADP
eurjchem-2615	637	24	the	the	DET
eurjchem-2615	637	25	fight	fight	NOUN
eurjchem-2615	637	26	against	against	ADP
eurjchem-2615	637	27	antibacterial	antibacterial	ADJ
eurjchem-2615	637	28	resistance	resistance	NOUN
eurjchem-2615	637	29	.	.	PUNCT
eurjchem-2615	638	1	pharmaceutics	pharmaceutic	NOUN
eurjchem-2615	638	2	2022	2022	NUM
eurjchem-2615	638	3	,	,	PUNCT
eurjchem-2615	638	4	14	14	NUM
eurjchem-2615	638	5	(	(	PUNCT
eurjchem-2615	638	6	8)	8)	NUM
eurjchem-2615	638	7	,	,	PUNCT
eurjchem-2615	638	8	1749	1749	NUM
eurjchem-2615	638	9	.	.	PUNCT
eurjchem-2615	639	1	[	[	X
eurjchem-2615	639	2	73	73	NUM
eurjchem-2615	639	3	]	]	PUNCT
eurjchem-2615	639	4	.	.	PUNCT
eurjchem-2615	640	1	ramachandran	ramachandran	PROPN
eurjchem-2615	640	2	,	,	PUNCT
eurjchem-2615	640	3	g.	g.	PROPN
eurjchem-2615	640	4	;	;	PUNCT
eurjchem-2615	640	5	swaminathan	swaminathan	ADV
eurjchem-2615	640	6	,	,	PUNCT
eurjchem-2615	640	7	s.	s.	PROPN
eurjchem-2615	640	8	safety	safety	PROPN
eurjchem-2615	640	9	and	and	CCONJ
eurjchem-2615	640	10	tolerability	tolerability	NOUN
eurjchem-2615	640	11	profile	profile	NOUN
eurjchem-2615	640	12	of	of	ADP
eurjchem-2615	640	13	second	second	ADJ
eurjchem-2615	640	14	-	-	PUNCT
eurjchem-2615	640	15	line	line	NOUN
eurjchem-2615	640	16	anti	anti	ADJ
eurjchem-2615	640	17	-	-	ADJ
eurjchem-2615	640	18	tuberculosis	tuberculosis	ADJ
eurjchem-2615	640	19	medications	medication	NOUN
eurjchem-2615	640	20	.	.	PUNCT
eurjchem-2615	641	1	drug	drug	PROPN
eurjchem-2615	641	2	saf	saf	PROPN
eurjchem-2615	641	3	.	.	PROPN
eurjchem-2615	641	4	2015	2015	NUM
eurjchem-2615	641	5	,	,	PUNCT
eurjchem-2615	641	6	38	38	NUM
eurjchem-2615	641	7	(	(	PUNCT
eurjchem-2615	641	8	3	3	NUM
eurjchem-2615	641	9	)	)	PUNCT
eurjchem-2615	641	10	,	,	PUNCT
eurjchem-2615	641	11	253–269	253–269	NUM
eurjchem-2615	641	12	.	.	PUNCT
eurjchem-2615	642	1	[	[	X
eurjchem-2615	642	2	74	74	NUM
eurjchem-2615	642	3	]	]	PUNCT
eurjchem-2615	642	4	.	.	PUNCT
eurjchem-2615	643	1	de	de	PROPN
eurjchem-2615	643	2	souza	souza	PROPN
eurjchem-2615	643	3	,	,	PUNCT
eurjchem-2615	643	4	m.	m.	NOUN
eurjchem-2615	643	5	;	;	PUNCT
eurjchem-2615	643	6	vasconcelos	vasconcelos	PROPN
eurjchem-2615	643	7	,	,	PUNCT
eurjchem-2615	643	8	t.	t.	PROPN
eurjchem-2615	643	9	;	;	PUNCT
eurjchem-2615	643	10	almeida	almeida	PROPN
eurjchem-2615	643	11	,	,	PUNCT
eurjchem-2615	643	12	m.	m.	NOUN
eurjchem-2615	643	13	;	;	PUNCT
eurjchem-2615	643	14	cardoso	cardoso	PROPN
eurjchem-2615	643	15	,	,	PUNCT
eurjchem-2615	643	16	s.	s.	PROPN
eurjchem-2615	643	17	fluoroquinolones	fluoroquinolones	PROPN
eurjchem-2615	643	18	:	:	PUNCT
eurjchem-2615	643	19	an	an	DET
eurjchem-2615	643	20	important	important	ADJ
eurjchem-2615	643	21	class	class	NOUN
eurjchem-2615	643	22	of	of	ADP
eurjchem-2615	643	23	antibiotics	antibiotic	NOUN
eurjchem-2615	643	24	against	against	ADP
eurjchem-2615	643	25	tuberculosis	tuberculosis	NOUN
eurjchem-2615	643	26	.	.	PUNCT
eurjchem-2615	644	1	cmc	cmc	PROPN
eurjchem-2615	644	2	.	.	PROPN
eurjchem-2615	645	1	2006	2006	NUM
eurjchem-2615	645	2	,	,	PUNCT
eurjchem-2615	645	3	13	13	NUM
eurjchem-2615	645	4	(	(	PUNCT
eurjchem-2615	645	5	4	4	NUM
eurjchem-2615	645	6	)	)	PUNCT
eurjchem-2615	645	7	,	,	PUNCT
eurjchem-2615	645	8	455–463	455–463	NUM
eurjchem-2615	645	9	.	.	PUNCT
eurjchem-2615	646	1	[	[	X
eurjchem-2615	646	2	75	75	NUM
eurjchem-2615	646	3	]	]	PUNCT
eurjchem-2615	646	4	.	.	PUNCT
eurjchem-2615	647	1	sriram	sriram	PROPN
eurjchem-2615	647	2	,	,	PUNCT
eurjchem-2615	647	3	d.	d.	PROPN
eurjchem-2615	647	4	;	;	PUNCT
eurjchem-2615	647	5	aubry	aubry	PROPN
eurjchem-2615	647	6	,	,	PUNCT
eurjchem-2615	647	7	a.	a.	PROPN
eurjchem-2615	647	8	;	;	PUNCT
eurjchem-2615	647	9	yogeeswari	yogeeswari	PROPN
eurjchem-2615	647	10	,	,	PUNCT
eurjchem-2615	647	11	p.	p.	NOUN
eurjchem-2615	647	12	;	;	PUNCT
eurjchem-2615	647	13	fisher	fisher	PROPN
eurjchem-2615	647	14	,	,	PUNCT
eurjchem-2615	647	15	l.	l.	PROPN
eurjchem-2615	647	16	gatifloxacin	gatifloxacin	PROPN
eurjchem-2615	647	17	derivatives	derivative	NOUN
eurjchem-2615	647	18	:	:	PUNCT
eurjchem-2615	647	19	synthesis	synthesis	NOUN
eurjchem-2615	647	20	,	,	PUNCT
eurjchem-2615	647	21	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	647	22	activities	activity	NOUN
eurjchem-2615	647	23	,	,	PUNCT
eurjchem-2615	647	24	and	and	CCONJ
eurjchem-2615	647	25	inhibition	inhibition	NOUN
eurjchem-2615	647	26	of	of	ADP
eurjchem-2615	647	27	mycobacterium	mycobacterium	NOUN
eurjchem-2615	647	28	tuberculosis	tuberculosis	NOUN
eurjchem-2615	647	29	dna	dna	PROPN
eurjchem-2615	647	30	gyrase	gyrase	NOUN
eurjchem-2615	647	31	.	.	PUNCT
eurjchem-2615	648	1	bioorg	bioorg	PROPN
eurjchem-2615	648	2	.	.	PUNCT
eurjchem-2615	649	1	med	med	PROPN
eurjchem-2615	649	2	.	.	PROPN
eurjchem-2615	649	3	chem	chem	PROPN
eurjchem-2615	649	4	.	.	PUNCT
eurjchem-2615	650	1	lett	lett	PROPN
eurjchem-2615	650	2	.	.	PUNCT
eurjchem-2615	651	1	2006	2006	NUM
eurjchem-2615	651	2	,	,	PUNCT
eurjchem-2615	651	3	16	16	NUM
eurjchem-2615	651	4	(	(	PUNCT
eurjchem-2615	651	5	11	11	NUM
eurjchem-2615	651	6	)	)	PUNCT
eurjchem-2615	651	7	,	,	PUNCT
eurjchem-2615	651	8	2982–2985	2982–2985	NUM
eurjchem-2615	651	9	.	.	PUNCT
eurjchem-2615	652	1	[	[	X
eurjchem-2615	652	2	76	76	NUM
eurjchem-2615	652	3	]	]	PUNCT
eurjchem-2615	652	4	.	.	PUNCT
eurjchem-2615	653	1	xu	xu	PROPN
eurjchem-2615	653	2	,	,	PUNCT
eurjchem-2615	653	3	z.	z.	PROPN
eurjchem-2615	653	4	;	;	PUNCT
eurjchem-2615	653	5	song	song	PROPN
eurjchem-2615	653	6	,	,	PUNCT
eurjchem-2615	653	7	x.	x.	PROPN
eurjchem-2615	653	8	;	;	PUNCT
eurjchem-2615	653	9	qiang	qiang	PROPN
eurjchem-2615	653	10	,	,	PUNCT
eurjchem-2615	653	11	m.	m.	NOUN
eurjchem-2615	653	12	;	;	PUNCT
eurjchem-2615	653	13	lv	lv	PROPN
eurjchem-2615	653	14	,	,	PUNCT
eurjchem-2615	653	15	z.	z.	PROPN
eurjchem-2615	653	16	1h-1,2,3	1h-1,2,3	PROPN
eurjchem-2615	653	17	-	-	PUNCT
eurjchem-2615	653	18	triazole	triazole	NOUN
eurjchem-2615	653	19	-	-	PUNCT
eurjchem-2615	653	20	tethered	tethered	ADJ
eurjchem-2615	653	21	8	8	NUM
eurjchem-2615	653	22	-	-	PUNCT
eurjchem-2615	653	23	ome	ome	NOUN
eurjchem-2615	653	24	ciprofloxacin	ciprofloxacin	NOUN
eurjchem-2615	653	25	and	and	CCONJ
eurjchem-2615	653	26	isatin	isatin	PROPN
eurjchem-2615	653	27	hybrids	hybrid	NOUN
eurjchem-2615	653	28	:	:	PUNCT
eurjchem-2615	653	29	design	design	NOUN
eurjchem-2615	653	30	,	,	PUNCT
eurjchem-2615	653	31	synthesis	synthesis	NOUN
eurjchem-2615	653	32	and	and	CCONJ
eurjchem-2615	653	33	in	in	ADP
eurjchem-2615	653	34	vitro	vitro	X
eurjchem-2615	653	35	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	653	36	activities	activity	NOUN
eurjchem-2615	653	37	.	.	PUNCT
eurjchem-2615	654	1	j.	j.	PROPN
eurjchem-2615	654	2	heterocyclic	heterocyclic	PROPN
eurjchem-2615	654	3	chem	chem	PROPN
eurjchem-2615	654	4	.	.	PUNCT
eurjchem-2615	655	1	2017	2017	NUM
eurjchem-2615	655	2	,	,	PUNCT
eurjchem-2615	655	3	54	54	NUM
eurjchem-2615	655	4	(	(	PUNCT
eurjchem-2615	655	5	6	6	NUM
eurjchem-2615	655	6	)	)	PUNCT
eurjchem-2615	655	7	,	,	PUNCT
eurjchem-2615	655	8	3735	3735	NUM
eurjchem-2615	655	9	–	–	PUNCT
eurjchem-2615	655	10	3741	3741	NUM
eurjchem-2615	655	11	.	.	PUNCT
eurjchem-2615	656	1	[	[	X
eurjchem-2615	656	2	77	77	NUM
eurjchem-2615	656	3	]	]	PUNCT
eurjchem-2615	656	4	.	.	PUNCT
eurjchem-2615	657	1	xu	xu	PROPN
eurjchem-2615	657	2	,	,	PUNCT
eurjchem-2615	657	3	z.	z.	PROPN
eurjchem-2615	657	4	;	;	PUNCT
eurjchem-2615	657	5	song	song	PROPN
eurjchem-2615	657	6	,	,	PUNCT
eurjchem-2615	657	7	x.	x.	PROPN
eurjchem-2615	657	8	;	;	PUNCT
eurjchem-2615	657	9	hu	hu	PROPN
eurjchem-2615	657	10	,	,	PUNCT
eurjchem-2615	657	11	y.	y.	PROPN
eurjchem-2615	657	12	;	;	PUNCT
eurjchem-2615	657	13	qiang	qiang	PROPN
eurjchem-2615	657	14	,	,	PUNCT
eurjchem-2615	657	15	m.	m.	NOUN
eurjchem-2615	657	16	;	;	PUNCT
eurjchem-2615	657	17	lv	lv	PROPN
eurjchem-2615	657	18	,	,	PUNCT
eurjchem-2615	657	19	z.	z.	PROPN
eurjchem-2615	657	20	design	design	PROPN
eurjchem-2615	657	21	,	,	PUNCT
eurjchem-2615	657	22	synthesis	synthesis	NOUN
eurjchem-2615	657	23	and	and	CCONJ
eurjchem-2615	657	24	in	in	ADP
eurjchem-2615	657	25	vitro	vitro	X
eurjchem-2615	657	26	anti	anti	ADJ
eurjchem-2615	657	27	-	-	ADJ
eurjchem-2615	657	28	mycobacterial	mycobacterial	ADJ
eurjchem-2615	657	29	activities	activity	NOUN
eurjchem-2615	657	30	of	of	ADP
eurjchem-2615	657	31	8	8	NUM
eurjchem-2615	657	32	-	-	PUNCT
eurjchem-2615	657	33	ome	ome	NOUN
eurjchem-2615	657	34	ciprofloxacin-1h-1,2,3triazole	ciprofloxacin-1h-1,2,3triazole	NOUN
eurjchem-2615	657	35	-	-	PUNCT
eurjchem-2615	657	36	isatin-(thio	isatin-(thio	ADJ
eurjchem-2615	657	37	)	)	PUNCT
eurjchem-2615	657	38	semicarbazide	semicarbazide	ADJ
eurjchem-2615	657	39	/	/	SYM
eurjchem-2615	657	40	oxime	oxime	NOUN
eurjchem-2615	657	41	hybrids	hybrid	NOUN
eurjchem-2615	657	42	.	.	PUNCT
eurjchem-2615	658	1	j.	j.	PROPN
eurjchem-2615	658	2	heterocyclic	heterocyclic	PROPN
eurjchem-2615	658	3	chem	chem	PROPN
eurjchem-2615	658	4	.	.	PUNCT
eurjchem-2615	659	1	2017	2017	NUM
eurjchem-2615	659	2	,	,	PUNCT
eurjchem-2615	659	3	55	55	NUM
eurjchem-2615	659	4	(	(	PUNCT
eurjchem-2615	659	5	1	1	NUM
eurjchem-2615	659	6	)	)	PUNCT
eurjchem-2615	659	7	,	,	PUNCT
eurjchem-2615	659	8	192–198	192–198	NUM
eurjchem-2615	659	9	.	.	PUNCT
eurjchem-2615	660	1	[	[	X
eurjchem-2615	660	2	78	78	NUM
eurjchem-2615	660	3	]	]	PUNCT
eurjchem-2615	660	4	.	.	PUNCT
eurjchem-2615	661	1	xu	xu	PROPN
eurjchem-2615	661	2	,	,	PUNCT
eurjchem-2615	661	3	z.	z.	PROPN
eurjchem-2615	661	4	;	;	PUNCT
eurjchem-2615	661	5	lv	lv	PROPN
eurjchem-2615	661	6	,	,	PUNCT
eurjchem-2615	661	7	z.	z.	PROPN
eurjchem-2615	661	8	;	;	PUNCT
eurjchem-2615	661	9	song	song	PROPN
eurjchem-2615	661	10	,	,	PUNCT
eurjchem-2615	661	11	x.	x.	PROPN
eurjchem-2615	661	12	;	;	PUNCT
eurjchem-2615	661	13	qiang	qiang	PROPN
eurjchem-2615	661	14	,	,	PUNCT
eurjchem-2615	661	15	m.	m.	NOUN
eurjchem-2615	661	16	ciprofloxacin	ciprofloxacin	PROPN
eurjchem-2615	661	17	-	-	PUNCT
eurjchem-2615	661	18	isatin-1h-1,2,3	isatin-1h-1,2,3	VERB
eurjchem-2615	661	19	-	-	PUNCT
eurjchem-2615	661	20	triazole	triazole	ADJ
eurjchem-2615	661	21	hybrids	hybrid	NOUN
eurjchem-2615	661	22	:	:	PUNCT
eurjchem-2615	661	23	design	design	NOUN
eurjchem-2615	661	24	,	,	PUNCT
eurjchem-2615	661	25	synthesis	synthesis	NOUN
eurjchem-2615	661	26	,	,	PUNCT
eurjchem-2615	661	27	and	and	CCONJ
eurjchem-2615	661	28	in	in	ADP
eurjchem-2615	661	29	vitro	vitro	X
eurjchem-2615	661	30	anti	anti	ADJ
eurjchem-2615	661	31	-	-	ADJ
eurjchem-2615	661	32	tubercular	tubercular	ADJ
eurjchem-2615	661	33	activity	activity	NOUN
eurjchem-2615	661	34	against	against	ADP
eurjchem-2615	661	35	m.	m.	NOUN
eurjchem-2615	661	36	tuberculosis	tuberculosis	NOUN
eurjchem-2615	661	37	.	.	PUNCT
eurjchem-2615	662	1	j.	j.	PROPN
eurjchem-2615	662	2	heterocyclic	heterocyclic	PROPN
eurjchem-2615	662	3	chem	chem	PROPN
eurjchem-2615	662	4	.	.	PUNCT
eurjchem-2615	663	1	2017	2017	NUM
eurjchem-2615	663	2	,	,	PUNCT
eurjchem-2615	663	3	55	55	NUM
eurjchem-2615	663	4	(	(	PUNCT
eurjchem-2615	663	5	1	1	NUM
eurjchem-2615	663	6	)	)	PUNCT
eurjchem-2615	663	7	,	,	PUNCT
eurjchem-2615	663	8	97–102	97–102	NUM
eurjchem-2615	663	9	.	.	PUNCT
eurjchem-2615	664	1	[	[	X
eurjchem-2615	664	2	79	79	NUM
eurjchem-2615	664	3	]	]	PUNCT
eurjchem-2615	664	4	.	.	PUNCT
eurjchem-2615	665	1	chen	chen	PROPN
eurjchem-2615	665	2	,	,	PUNCT
eurjchem-2615	665	3	r.	r.	PROPN
eurjchem-2615	665	4	;	;	PUNCT
eurjchem-2615	665	5	zhang	zhang	PROPN
eurjchem-2615	665	6	,	,	PUNCT
eurjchem-2615	665	7	h.	h.	PROPN
eurjchem-2615	665	8	;	;	PUNCT
eurjchem-2615	665	9	ma	ma	PROPN
eurjchem-2615	665	10	,	,	PUNCT
eurjchem-2615	665	11	t.	t.	PROPN
eurjchem-2615	665	12	;	;	PUNCT
eurjchem-2615	665	13	xue	xue	PROPN
eurjchem-2615	665	14	,	,	PUNCT
eurjchem-2615	665	15	h.	h.	PROPN
eurjchem-2615	665	16	;	;	PUNCT
eurjchem-2615	665	17	miao	miao	PROPN
eurjchem-2615	665	18	,	,	PUNCT
eurjchem-2615	665	19	z.	z.	PROPN
eurjchem-2615	665	20	;	;	PUNCT
eurjchem-2615	665	21	chen	chen	PROPN
eurjchem-2615	665	22	,	,	PUNCT
eurjchem-2615	665	23	l.	l.	PROPN
eurjchem-2615	665	24	;	;	PUNCT
eurjchem-2615	665	25	shi	shi	PROPN
eurjchem-2615	665	26	,	,	PUNCT
eurjchem-2615	665	27	x.	x.	NOUN
eurjchem-2615	665	28	ciprofloxacin-1,2,3	ciprofloxacin-1,2,3	PROPN
eurjchem-2615	665	29	-	-	PUNCT
eurjchem-2615	665	30	triazole	triazole	NOUN
eurjchem-2615	665	31	-	-	PUNCT
eurjchem-2615	665	32	isatin	isatin	NOUN
eurjchem-2615	665	33	hybrids	hybrid	NOUN
eurjchem-2615	665	34	tethered	tether	VERB
eurjchem-2615	665	35	via	via	ADP
eurjchem-2615	665	36	amide	amide	NOUN
eurjchem-2615	665	37	:	:	PUNCT
eurjchem-2615	665	38	design	design	NOUN
eurjchem-2615	665	39	,	,	PUNCT
eurjchem-2615	665	40	synthesis	synthesis	NOUN
eurjchem-2615	665	41	,	,	PUNCT
eurjchem-2615	665	42	and	and	CCONJ
eurjchem-2615	665	43	in	in	ADP
eurjchem-2615	665	44	vitro	vitro	X
eurjchem-2615	665	45	anti	anti	ADJ
eurjchem-2615	665	46	-	-	ADJ
eurjchem-2615	665	47	mycobacterial	mycobacterial	ADJ
eurjchem-2615	665	48	activity	activity	NOUN
eurjchem-2615	665	49	evaluation	evaluation	NOUN
eurjchem-2615	665	50	.	.	PUNCT
eurjchem-2615	666	1	bioorg	bioorg	PROPN
eurjchem-2615	666	2	.	.	PUNCT
eurjchem-2615	667	1	med	med	PROPN
eurjchem-2615	667	2	.	.	PROPN
eurjchem-2615	667	3	chem	chem	PROPN
eurjchem-2615	667	4	.	.	PUNCT
eurjchem-2615	668	1	lett	lett	PROPN
eurjchem-2615	668	2	.	.	PROPN
eurjchem-2615	669	1	2019	2019	NUM
eurjchem-2615	669	2	,	,	PUNCT
eurjchem-2615	669	3	29	29	NUM
eurjchem-2615	669	4	(	(	PUNCT
eurjchem-2615	669	5	18	18	NUM
eurjchem-2615	669	6	)	)	PUNCT
eurjchem-2615	669	7	,	,	PUNCT
eurjchem-2615	669	8	2635–2637	2635–2637	NUM
eurjchem-2615	669	9	.	.	PUNCT
eurjchem-2615	670	1	[	[	X
eurjchem-2615	670	2	80	80	NUM
eurjchem-2615	670	3	]	]	PUNCT
eurjchem-2615	670	4	.	.	PUNCT
eurjchem-2615	671	1	ding	ding	PROPN
eurjchem-2615	671	2	,	,	PUNCT
eurjchem-2615	671	3	z.	z.	PROPN
eurjchem-2615	671	4	;	;	PUNCT
eurjchem-2615	671	5	hou	hou	PROPN
eurjchem-2615	671	6	,	,	PUNCT
eurjchem-2615	671	7	p.	p.	PROPN
eurjchem-2615	671	8	;	;	PUNCT
eurjchem-2615	672	1	liu	liu	PROPN
eurjchem-2615	672	2	,	,	PUNCT
eurjchem-2615	672	3	b.	b.	PROPN
eurjchem-2615	672	4	gatifloxacin-1,2,3	gatifloxacin-1,2,3	PROPN
eurjchem-2615	672	5	-	-	PUNCT
eurjchem-2615	672	6	triazole	triazole	NOUN
eurjchem-2615	672	7	-	-	PUNCT
eurjchem-2615	672	8	isatin	isatin	NOUN
eurjchem-2615	672	9	hybrids	hybrid	NOUN
eurjchem-2615	672	10	and	and	CCONJ
eurjchem-2615	672	11	their	their	PRON
eurjchem-2615	672	12	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	672	13	activities	activity	NOUN
eurjchem-2615	672	14	.	.	PUNCT
eurjchem-2615	673	1	arch	arch	NOUN
eurjchem-2615	673	2	.	.	PUNCT
eurjchem-2615	674	1	pharm	pharm	NOUN
eurjchem-2615	674	2	.	.	PUNCT
eurjchem-2615	675	1	2019	2019	NUM
eurjchem-2615	675	2	,	,	PUNCT
eurjchem-2615	675	3	352	352	NUM
eurjchem-2615	675	4	(	(	PUNCT
eurjchem-2615	675	5	10	10	NUM
eurjchem-2615	675	6	)	)	PUNCT
eurjchem-2615	675	7	,	,	PUNCT
eurjchem-2615	675	8	https://doi.org/10.1002/ardp.201900135	https://doi.org/10.1002/ardp.201900135	NOUN
eurjchem-2615	675	9	.	.	PUNCT
eurjchem-2615	676	1	[	[	X
eurjchem-2615	676	2	81	81	NUM
eurjchem-2615	676	3	]	]	PUNCT
eurjchem-2615	676	4	.	.	PUNCT
eurjchem-2615	677	1	kumar	kumar	PROPN
eurjchem-2615	677	2	,	,	PUNCT
eurjchem-2615	677	3	k.	k.	PROPN
eurjchem-2615	677	4	;	;	PUNCT
eurjchem-2615	677	5	carrère	carrère	NOUN
eurjchem-2615	677	6	-	-	PUNCT
eurjchem-2615	677	7	kremer	kremer	PROPN
eurjchem-2615	677	8	,	,	PUNCT
eurjchem-2615	677	9	s.	s.	PROPN
eurjchem-2615	677	10	;	;	PUNCT
eurjchem-2615	677	11	kremer	kremer	PROPN
eurjchem-2615	677	12	,	,	PUNCT
eurjchem-2615	677	13	l.	l.	PROPN
eurjchem-2615	677	14	;	;	PUNCT
eurjchem-2615	677	15	guérardel	guérardel	NOUN
eurjchem-2615	677	16	,	,	PUNCT
eurjchem-2615	677	17	y.	y.	PROPN
eurjchem-2615	677	18	;	;	PUNCT
eurjchem-2615	677	19	biot	biot	PROPN
eurjchem-2615	677	20	,	,	PUNCT
eurjchem-2615	677	21	c.	c.	PROPN
eurjchem-2615	677	22	;	;	PUNCT
eurjchem-2615	677	23	kumar	kumar	PROPN
eurjchem-2615	677	24	,	,	PUNCT
eurjchem-2615	677	25	v.	v.	PROPN
eurjchem-2615	677	26	1h-1,2,3	1h-1,2,3	NUM
eurjchem-2615	677	27	-	-	PUNCT
eurjchem-2615	677	28	triazole	triazole	NOUN
eurjchem-2615	677	29	-	-	PUNCT
eurjchem-2615	677	30	tethered	tethered	ADJ
eurjchem-2615	677	31	isatin	isatin	NOUN
eurjchem-2615	677	32	–	–	PUNCT
eurjchem-2615	677	33	ferrocene	ferrocene	NOUN
eurjchem-2615	677	34	and	and	CCONJ
eurjchem-2615	677	35	isatin	isatin	PROPN
eurjchem-2615	677	36	–	–	PUNCT
eurjchem-2615	677	37	ferrocenylchalcone	ferrocenylchalcone	NOUN
eurjchem-2615	677	38	conjugates	conjugate	NOUN
eurjchem-2615	677	39	:	:	PUNCT
eurjchem-2615	677	40	synthesis	synthesis	NOUN
eurjchem-2615	677	41	and	and	CCONJ
eurjchem-2615	677	42	in	in	ADP
eurjchem-2615	677	43	vitro	vitro	X
eurjchem-2615	677	44	antitubercular	antitubercular	ADJ
eurjchem-2615	677	45	evaluation	evaluation	NOUN
eurjchem-2615	677	46	.	.	PUNCT
eurjchem-2615	678	1	organometallics	organometallic	NOUN
eurjchem-2615	678	2	2013	2013	NUM
eurjchem-2615	678	3	,	,	PUNCT
eurjchem-2615	678	4	32	32	NUM
eurjchem-2615	678	5	(	(	PUNCT
eurjchem-2615	678	6	20	20	NUM
eurjchem-2615	678	7	)	)	PUNCT
eurjchem-2615	678	8	,	,	PUNCT
eurjchem-2615	678	9	5713–5719	5713–5719	NUM
eurjchem-2615	678	10	.	.	PUNCT
eurjchem-2615	679	1	[	[	X
eurjchem-2615	679	2	82	82	NUM
eurjchem-2615	679	3	]	]	PUNCT
eurjchem-2615	679	4	.	.	PUNCT
eurjchem-2615	680	1	singh	singh	PROPN
eurjchem-2615	680	2	,	,	PUNCT
eurjchem-2615	680	3	a.	a.	NOUN
eurjchem-2615	680	4	;	;	PUNCT
eurjchem-2615	680	5	biot	biot	PROPN
eurjchem-2615	680	6	,	,	PUNCT
eurjchem-2615	680	7	c.	c.	PROPN
eurjchem-2615	680	8	;	;	PUNCT
eurjchem-2615	680	9	viljoen	viljoen	X
eurjchem-2615	680	10	,	,	PUNCT
eurjchem-2615	680	11	a.	a.	NOUN
eurjchem-2615	680	12	;	;	PUNCT
eurjchem-2615	680	13	dupont	dupont	PROPN
eurjchem-2615	680	14	,	,	PUNCT
eurjchem-2615	680	15	c.	c.	PROPN
eurjchem-2615	680	16	;	;	PUNCT
eurjchem-2615	680	17	kremer	kremer	PROPN
eurjchem-2615	680	18	,	,	PUNCT
eurjchem-2615	680	19	l.	l.	PROPN
eurjchem-2615	680	20	;	;	PUNCT
eurjchem-2615	680	21	kumar	kumar	PROPN
eurjchem-2615	680	22	,	,	PUNCT
eurjchem-2615	680	23	k.	k.	PROPN
eurjchem-2615	680	24	;	;	PUNCT
eurjchem-2615	680	25	kumar	kumar	PROPN
eurjchem-2615	680	26	,	,	PUNCT
eurjchem-2615	680	27	v.	v.	PROPN
eurjchem-2615	680	28	1h-1,2,3	1h-1,2,3	NUM
eurjchem-2615	680	29	-	-	PUNCT
eurjchem-2615	680	30	triazole	triazole	NOUN
eurjchem-2615	680	31	-	-	PUNCT
eurjchem-2615	680	32	tethered	tethered	ADJ
eurjchem-2615	680	33	uracil	uracil	NOUN
eurjchem-2615	680	34	-	-	PUNCT
eurjchem-2615	680	35	ferrocene	ferrocene	NOUN
eurjchem-2615	680	36	and	and	CCONJ
eurjchem-2615	680	37	uracilferrocenylchalcone	uracilferrocenylchalcone	ADJ
eurjchem-2615	680	38	conjugates	conjugate	NOUN
eurjchem-2615	680	39	:	:	PUNCT
eurjchem-2615	680	40	synthesis	synthesis	NOUN
eurjchem-2615	680	41	and	and	CCONJ
eurjchem-2615	680	42	antitubercular	antitubercular	ADJ
eurjchem-2615	680	43	evaluation	evaluation	NOUN
eurjchem-2615	680	44	.	.	PUNCT
eurjchem-2615	681	1	chem	chem	NOUN
eurjchem-2615	681	2	.	.	PUNCT
eurjchem-2615	682	1	biol	biol	PROPN
eurjchem-2615	682	2	.	.	PUNCT
eurjchem-2615	683	1	drug	drug	NOUN
eurjchem-2615	683	2	.	.	PUNCT
eurjchem-2615	684	1	des	des	PROPN
eurjchem-2615	684	2	.	.	PROPN
eurjchem-2615	684	3	2016	2016	NUM
eurjchem-2615	684	4	,	,	PUNCT
eurjchem-2615	684	5	89	89	NUM
eurjchem-2615	684	6	(	(	PUNCT
eurjchem-2615	684	7	6	6	NUM
eurjchem-2615	684	8	)	)	PUNCT
eurjchem-2615	684	9	,	,	PUNCT
eurjchem-2615	684	10	856–861	856–861	NUM
eurjchem-2615	684	11	.	.	PUNCT
eurjchem-2615	685	1	[	[	X
eurjchem-2615	685	2	83	83	NUM
eurjchem-2615	685	3	]	]	PUNCT
eurjchem-2615	685	4	.	.	PUNCT
eurjchem-2615	686	1	kancharla	kancharla	PROPN
eurjchem-2615	686	2	,	,	PUNCT
eurjchem-2615	686	3	s.	s.	PROPN
eurjchem-2615	686	4	k.	k.	PROPN
eurjchem-2615	686	5	;	;	PUNCT
eurjchem-2615	686	6	birudaraju	birudaraju	PROPN
eurjchem-2615	686	7	,	,	PUNCT
eurjchem-2615	686	8	s.	s.	PROPN
eurjchem-2615	686	9	;	;	PUNCT
eurjchem-2615	686	10	pal	pal	NOUN
eurjchem-2615	686	11	,	,	PUNCT
eurjchem-2615	686	12	a.	a.	NOUN
eurjchem-2615	686	13	;	;	PUNCT
eurjchem-2615	686	14	krishnakanth	krishnakanth	PROPN
eurjchem-2615	686	15	reddy	reddy	PROPN
eurjchem-2615	686	16	,	,	PUNCT
eurjchem-2615	686	17	l.	l.	PROPN
eurjchem-2615	686	18	;	;	PUNCT
eurjchem-2615	686	19	reddy	reddy	PROPN
eurjchem-2615	686	20	,	,	PUNCT
eurjchem-2615	686	21	e.	e.	PROPN
eurjchem-2615	686	22	r.	r.	PROPN
eurjchem-2615	686	23	;	;	PUNCT
eurjchem-2615	686	24	vagolu	vagolu	PROPN
eurjchem-2615	686	25	,	,	PUNCT
eurjchem-2615	686	26	s.	s.	PROPN
eurjchem-2615	686	27	k.	k.	PROPN
eurjchem-2615	686	28	;	;	PUNCT
eurjchem-2615	686	29	sriram	sriram	PROPN
eurjchem-2615	686	30	,	,	PUNCT
eurjchem-2615	686	31	d.	d.	PROPN
eurjchem-2615	686	32	;	;	PUNCT
eurjchem-2615	686	33	bonige	bonige	PROPN
eurjchem-2615	686	34	,	,	PUNCT
eurjchem-2615	686	35	k.	k.	PROPN
eurjchem-2615	686	36	b.	b.	PROPN
eurjchem-2615	686	37	;	;	PUNCT
eurjchem-2615	686	38	korupolu	korupolu	PROPN
eurjchem-2615	686	39	,	,	PUNCT
eurjchem-2615	686	40	r.	r.	PROPN
eurjchem-2615	686	41	b.	b.	PROPN
eurjchem-2615	686	42	synthesis	synthesis	PROPN
eurjchem-2615	686	43	and	and	CCONJ
eurjchem-2615	686	44	biological	biological	ADJ
eurjchem-2615	686	45	evaluation	evaluation	NOUN
eurjchem-2615	686	46	of	of	ADP
eurjchem-2615	686	47	isatin	isatin	PROPN
eurjchem-2615	686	48	oxime	oxime	PROPN
eurjchem-2615	686	49	ether	ether	NOUN
eurjchem-2615	686	50	-	-	PUNCT
eurjchem-2615	686	51	tethered	tethered	ADJ
eurjchem-2615	686	52	aryl	aryl	NOUN
eurjchem-2615	686	53	1h-1,2,3triazoles	1h-1,2,3triazole	NOUN
eurjchem-2615	686	54	as	as	ADP
eurjchem-2615	686	55	inhibitors	inhibitor	NOUN
eurjchem-2615	686	56	of	of	ADP
eurjchem-2615	686	57	mycobacterium	mycobacterium	NOUN
eurjchem-2615	686	58	tuberculosis	tuberculosis	NOUN
eurjchem-2615	686	59	.	.	PUNCT
eurjchem-2615	687	1	new	new	ADJ
eurjchem-2615	687	2	j.	j.	PROPN
eurjchem-2615	687	3	chem	chem	PROPN
eurjchem-2615	687	4	.	.	PUNCT
eurjchem-2615	688	1	2022	2022	NUM
eurjchem-2615	688	2	,	,	PUNCT
eurjchem-2615	688	3	46	46	NUM
eurjchem-2615	688	4	(	(	PUNCT
eurjchem-2615	688	5	6	6	NUM
eurjchem-2615	688	6	)	)	PUNCT
eurjchem-2615	688	7	,	,	PUNCT
eurjchem-2615	688	8	2863–2874	2863–2874	NUM
eurjchem-2615	688	9	.	.	PUNCT
eurjchem-2615	689	1	[	[	X
eurjchem-2615	689	2	84	84	NUM
eurjchem-2615	689	3	]	]	PUNCT
eurjchem-2615	689	4	.	.	PUNCT
eurjchem-2615	689	5	sharma	sharma	PROPN
eurjchem-2615	689	6	,	,	PUNCT
eurjchem-2615	689	7	b.	b.	PROPN
eurjchem-2615	689	8	;	;	PUNCT
eurjchem-2615	689	9	kumar	kumar	PROPN
eurjchem-2615	689	10	,	,	PUNCT
eurjchem-2615	689	11	s.	s.	PROPN
eurjchem-2615	689	12	;	;	PUNCT
eurjchem-2615	689	13	preeti	preeti	PROPN
eurjchem-2615	689	14	;	;	PUNCT
eurjchem-2615	689	15	johansen	johansen	PROPN
eurjchem-2615	689	16	,	,	PUNCT
eurjchem-2615	689	17	m.	m.	PROPN
eurjchem-2615	689	18	d.	d.	PROPN
eurjchem-2615	689	19	;	;	PUNCT
eurjchem-2615	689	20	kremer	kremer	PROPN
eurjchem-2615	689	21	,	,	PUNCT
eurjchem-2615	689	22	l.	l.	PROPN
eurjchem-2615	689	23	;	;	PUNCT
eurjchem-2615	689	24	kumar	kumar	PROPN
eurjchem-2615	689	25	,	,	PUNCT
eurjchem-2615	689	26	v.	v.	PROPN
eurjchem-2615	689	27	1h-1,2,3	1h-1,2,3	NOUN
eurjchem-2615	689	28	-	-	PUNCT
eurjchem-2615	689	29	triazole	triazole	NOUN
eurjchem-2615	689	30	embedded	embed	VERB
eurjchem-2615	689	31	isatin	isatin	PROPN
eurjchem-2615	689	32	-	-	PUNCT
eurjchem-2615	689	33	benzaldehyde	benzaldehyde	NOUN
eurjchem-2615	689	34	-	-	PUNCT
eurjchem-2615	689	35	bis(heteronuclear	bis(heteronuclear	NOUN
eurjchem-2615	689	36	hydrazones	hydrazone	NOUN
eurjchem-2615	689	37	):	):	PUNCT
eurjchem-2615	689	38	design	design	NOUN
eurjchem-2615	689	39	,	,	PUNCT
eurjchem-2615	689	40	synthesis	synthesis	NOUN
eurjchem-2615	689	41	,	,	PUNCT
eurjchem-2615	689	42	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	689	43	,	,	PUNCT
eurjchem-2615	689	44	and	and	CCONJ
eurjchem-2615	689	45	cytotoxic	cytotoxic	ADJ
eurjchem-2615	689	46	evaluation	evaluation	NOUN
eurjchem-2615	689	47	.	.	PUNCT
eurjchem-2615	690	1	chem	chem	NOUN
eurjchem-2615	690	2	.	.	PUNCT
eurjchem-2615	691	1	biol	biol	PROPN
eurjchem-2615	691	2	.	.	PUNCT
eurjchem-2615	692	1	drug	drug	NOUN
eurjchem-2615	692	2	.	.	PUNCT
eurjchem-2615	693	1	des	des	PROPN
eurjchem-2615	693	2	.	.	PROPN
eurjchem-2615	693	3	2021	2021	NUM
eurjchem-2615	693	4	,	,	PUNCT
eurjchem-2615	693	5	99	99	NUM
eurjchem-2615	693	6	(	(	PUNCT
eurjchem-2615	693	7	2	2	NUM
eurjchem-2615	693	8	)	)	PUNCT
eurjchem-2615	693	9	,	,	PUNCT
eurjchem-2615	693	10	301–307	301–307	NUM
eurjchem-2615	693	11	.	.	PUNCT
eurjchem-2615	694	1	[	[	X
eurjchem-2615	694	2	85	85	NUM
eurjchem-2615	694	3	]	]	PUNCT
eurjchem-2615	694	4	.	.	PUNCT
eurjchem-2615	695	1	shaikh	shaikh	PROPN
eurjchem-2615	695	2	,	,	PUNCT
eurjchem-2615	695	3	m.	m.	PROPN
eurjchem-2615	695	4	h.	h.	PROPN
eurjchem-2615	695	5	;	;	PUNCT
eurjchem-2615	695	6	subhedar	subhedar	ADV
eurjchem-2615	695	7	,	,	PUNCT
eurjchem-2615	695	8	d.	d.	PROPN
eurjchem-2615	695	9	d.	d.	PROPN
eurjchem-2615	695	10	;	;	PUNCT
eurjchem-2615	695	11	khan	khan	PROPN
eurjchem-2615	695	12	,	,	PUNCT
eurjchem-2615	695	13	f.	f.	PROPN
eurjchem-2615	695	14	a.	a.	PROPN
eurjchem-2615	695	15	;	;	PUNCT
eurjchem-2615	695	16	sangshetti	sangshetti	PROPN
eurjchem-2615	695	17	,	,	PUNCT
eurjchem-2615	695	18	j.	j.	PROPN
eurjchem-2615	695	19	n.	n.	PROPN
eurjchem-2615	695	20	;	;	PUNCT
eurjchem-2615	695	21	nawale	nawale	PROPN
eurjchem-2615	695	22	,	,	PUNCT
eurjchem-2615	695	23	l.	l.	PROPN
eurjchem-2615	695	24	;	;	PUNCT
eurjchem-2615	695	25	arkile	arkile	NOUN
eurjchem-2615	695	26	,	,	PUNCT
eurjchem-2615	695	27	m.	m.	NOUN
eurjchem-2615	695	28	;	;	PUNCT
eurjchem-2615	695	29	sarkar	sarkar	PROPN
eurjchem-2615	695	30	,	,	PUNCT
eurjchem-2615	695	31	d.	d.	PROPN
eurjchem-2615	695	32	;	;	PUNCT
eurjchem-2615	695	33	shingate	shingate	VERB
eurjchem-2615	695	34	,	,	PUNCT
eurjchem-2615	695	35	b.	b.	PROPN
eurjchem-2615	695	36	b.	b.	PROPN
eurjchem-2615	695	37	synthesis	synthesis	NOUN
eurjchem-2615	695	38	of	of	ADP
eurjchem-2615	695	39	novel	novel	NOUN
eurjchem-2615	695	40	triazoleincorporated	triazoleincorporate	VERB
eurjchem-2615	695	41	isatin	isatin	ADJ
eurjchem-2615	695	42	derivatives	derivative	NOUN
eurjchem-2615	695	43	as	as	ADP
eurjchem-2615	695	44	antifungal	antifungal	ADJ
eurjchem-2615	695	45	,	,	PUNCT
eurjchem-2615	695	46	antitubercular	antitubercular	ADJ
eurjchem-2615	695	47	,	,	PUNCT
eurjchem-2615	695	48	and	and	CCONJ
eurjchem-2615	695	49	antioxidant	antioxidant	ADJ
eurjchem-2615	695	50	agents	agent	NOUN
eurjchem-2615	695	51	and	and	CCONJ
eurjchem-2615	695	52	molecular	molecular	ADJ
eurjchem-2615	695	53	docking	docking	NOUN
eurjchem-2615	695	54	study	study	NOUN
eurjchem-2615	695	55	.	.	PUNCT
eurjchem-2615	696	1	j.	j.	PROPN
eurjchem-2615	696	2	heterocyclic	heterocyclic	PROPN
eurjchem-2615	696	3	chem	chem	PROPN
eurjchem-2615	696	4	.	.	PUNCT
eurjchem-2615	697	1	2016	2016	NUM
eurjchem-2615	697	2	,	,	PUNCT
eurjchem-2615	697	3	54	54	NUM
eurjchem-2615	697	4	(	(	PUNCT
eurjchem-2615	697	5	1	1	NUM
eurjchem-2615	697	6	)	)	PUNCT
eurjchem-2615	697	7	,	,	PUNCT
eurjchem-2615	697	8	413–421	413–421	NUM
eurjchem-2615	697	9	.	.	PUNCT
eurjchem-2615	698	1	[	[	X
eurjchem-2615	698	2	86	86	NUM
eurjchem-2615	698	3	]	]	PUNCT
eurjchem-2615	698	4	.	.	PUNCT
eurjchem-2615	699	1	zhao	zhao	PROPN
eurjchem-2615	699	2	,	,	PUNCT
eurjchem-2615	699	3	s.	s.	PROPN
eurjchem-2615	699	4	;	;	PUNCT
eurjchem-2615	699	5	lv	lv	PROPN
eurjchem-2615	699	6	,	,	PUNCT
eurjchem-2615	699	7	z.	z.	PROPN
eurjchem-2615	699	8	;	;	PUNCT
eurjchem-2615	699	9	deng	deng	PROPN
eurjchem-2615	699	10	,	,	PUNCT
eurjchem-2615	699	11	j.	j.	PROPN
eurjchem-2615	699	12	;	;	PUNCT
eurjchem-2615	699	13	gao	gao	PROPN
eurjchem-2615	699	14	,	,	PUNCT
eurjchem-2615	699	15	f.	f.	PROPN
eurjchem-2615	699	16	;	;	PUNCT
eurjchem-2615	699	17	zhang	zhang	PROPN
eurjchem-2615	699	18	,	,	PUNCT
eurjchem-2615	699	19	g.	g.	PROPN
eurjchem-2615	699	20	;	;	PUNCT
eurjchem-2615	699	21	xu	xu	PROPN
eurjchem-2615	699	22	,	,	PUNCT
eurjchem-2615	699	23	z.	z.	PROPN
eurjchem-2615	699	24	design	design	PROPN
eurjchem-2615	699	25	,	,	PUNCT
eurjchem-2615	699	26	synthesis	synthesis	NOUN
eurjchem-2615	699	27	,	,	PUNCT
eurjchem-2615	699	28	and	and	CCONJ
eurjchem-2615	699	29	in	in	ADP
eurjchem-2615	699	30	vitro	vitro	X
eurjchem-2615	699	31	anti	anti	ADJ
eurjchem-2615	699	32	-	-	ADJ
eurjchem-2615	699	33	mycobacterial	mycobacterial	ADJ
eurjchem-2615	699	34	activities	activity	NOUN
eurjchem-2615	699	35	of	of	ADP
eurjchem-2615	699	36	1,2,3	1,2,3	NUM
eurjchem-2615	699	37	-	-	ADJ
eurjchem-2615	699	38	triazole	triazole	ADJ
eurjchem-2615	699	39	-	-	PUNCT
eurjchem-2615	699	40	tetraethylene	tetraethylene	NOUN
eurjchem-2615	699	41	glycol	glycol	NOUN
eurjchem-2615	699	42	tethered	tether	VERB
eurjchem-2615	699	43	isatin	isatin	PROPN
eurjchem-2615	699	44	dimers	dimers	PROPN
eurjchem-2615	699	45	.	.	PUNCT
eurjchem-2615	700	1	j.	j.	PROPN
eurjchem-2615	700	2	heterocyclic	heterocyclic	PROPN
eurjchem-2615	700	3	chem	chem	PROPN
eurjchem-2615	700	4	.	.	PUNCT
eurjchem-2615	701	1	2018	2018	NUM
eurjchem-2615	701	2	,	,	PUNCT
eurjchem-2615	701	3	55	55	NUM
eurjchem-2615	701	4	(	(	PUNCT
eurjchem-2615	701	5	12	12	NUM
eurjchem-2615	701	6	)	)	PUNCT
eurjchem-2615	701	7	,	,	PUNCT
eurjchem-2615	701	8	3006–3010	3006–3010	NUM
eurjchem-2615	701	9	.	.	PUNCT
eurjchem-2615	702	1	[	[	X
eurjchem-2615	702	2	87	87	NUM
eurjchem-2615	702	3	]	]	PUNCT
eurjchem-2615	702	4	.	.	PUNCT
eurjchem-2615	703	1	kedderis	kedderis	PROPN
eurjchem-2615	703	2	,	,	PUNCT
eurjchem-2615	703	3	g.	g.	PROPN
eurjchem-2615	703	4	l.	l.	PROPN
eurjchem-2615	703	5	;	;	PUNCT
eurjchem-2615	703	6	miwa	miwa	PROPN
eurjchem-2615	703	7	,	,	PUNCT
eurjchem-2615	703	8	g.	g.	PROPN
eurjchem-2615	703	9	t.	t.	PROPN
eurjchem-2615	704	1	the	the	DET
eurjchem-2615	704	2	metabolic	metabolic	NOUN
eurjchem-2615	704	3	activation	activation	NOUN
eurjchem-2615	704	4	of	of	ADP
eurjchem-2615	704	5	nitroheterocyclic	nitroheterocyclic	ADJ
eurjchem-2615	704	6	therapeutic	therapeutic	ADJ
eurjchem-2615	704	7	agents	agent	NOUN
eurjchem-2615	704	8	.	.	PUNCT
eurjchem-2615	705	1	drug	drug	NOUN
eurjchem-2615	705	2	metab	metab	PROPN
eurjchem-2615	705	3	.	.	PUNCT
eurjchem-2615	706	1	rev	rev	PROPN
eurjchem-2615	706	2	.	.	PROPN
eurjchem-2615	706	3	1988	1988	NUM
eurjchem-2615	706	4	,	,	PUNCT
eurjchem-2615	706	5	19	19	NUM
eurjchem-2615	706	6	(	(	PUNCT
eurjchem-2615	706	7	1	1	NUM
eurjchem-2615	706	8	)	)	PUNCT
eurjchem-2615	706	9	,	,	PUNCT
eurjchem-2615	706	10	33–62	33–62	NUM
eurjchem-2615	706	11	.	.	PUNCT
eurjchem-2615	707	1	[	[	X
eurjchem-2615	707	2	88	88	NUM
eurjchem-2615	707	3	]	]	PUNCT
eurjchem-2615	707	4	.	.	PUNCT
eurjchem-2615	708	1	jordão	jordão	PROPN
eurjchem-2615	708	2	,	,	PUNCT
eurjchem-2615	708	3	a.	a.	PROPN
eurjchem-2615	708	4	k.	k.	PROPN
eurjchem-2615	708	5	;	;	PUNCT
eurjchem-2615	708	6	sathler	sathler	NOUN
eurjchem-2615	708	7	,	,	PUNCT
eurjchem-2615	708	8	p.	p.	PROPN
eurjchem-2615	708	9	c.	c.	PROPN
eurjchem-2615	708	10	;	;	PUNCT
eurjchem-2615	708	11	ferreira	ferreira	PROPN
eurjchem-2615	708	12	,	,	PUNCT
eurjchem-2615	708	13	v.	v.	PROPN
eurjchem-2615	708	14	f.	f.	PROPN
eurjchem-2615	708	15	;	;	PUNCT
eurjchem-2615	708	16	campos	campos	PROPN
eurjchem-2615	708	17	,	,	PUNCT
eurjchem-2615	708	18	v.	v.	PROPN
eurjchem-2615	708	19	r.	r.	PROPN
eurjchem-2615	708	20	;	;	PUNCT
eurjchem-2615	708	21	de	de	PROPN
eurjchem-2615	708	22	souza	souza	PROPN
eurjchem-2615	708	23	,	,	PUNCT
eurjchem-2615	708	24	m.	m.	PROPN
eurjchem-2615	708	25	c.	c.	PROPN
eurjchem-2615	708	26	;	;	PUNCT
eurjchem-2615	708	27	castro	castro	PROPN
eurjchem-2615	708	28	,	,	PUNCT
eurjchem-2615	708	29	h.	h.	PROPN
eurjchem-2615	708	30	c.	c.	PROPN
eurjchem-2615	708	31	;	;	PUNCT
eurjchem-2615	708	32	lannes	lanne	NOUN
eurjchem-2615	708	33	,	,	PUNCT
eurjchem-2615	708	34	a.	a.	NOUN
eurjchem-2615	708	35	;	;	PUNCT
eurjchem-2615	708	36	lourenco	lourenco	PROPN
eurjchem-2615	708	37	,	,	PUNCT
eurjchem-2615	708	38	a.	a.	NOUN
eurjchem-2615	708	39	;	;	PUNCT
eurjchem-2615	708	40	rodrigues	rodrigues	PROPN
eurjchem-2615	708	41	,	,	PUNCT
eurjchem-2615	708	42	c.	c.	PROPN
eurjchem-2615	708	43	r.	r.	PROPN
eurjchem-2615	708	44	;	;	PUNCT
eurjchem-2615	708	45	bello	bello	PROPN
eurjchem-2615	708	46	,	,	PUNCT
eurjchem-2615	708	47	m.	m.	PROPN
eurjchem-2615	708	48	l.	l.	PROPN
eurjchem-2615	708	49	;	;	PUNCT
eurjchem-2615	708	50	lourenco	lourenco	PROPN
eurjchem-2615	708	51	,	,	PUNCT
eurjchem-2615	708	52	m.	m.	PROPN
eurjchem-2615	708	53	c.	c.	PROPN
eurjchem-2615	708	54	;	;	PUNCT
eurjchem-2615	708	55	carvalho	carvalho	PROPN
eurjchem-2615	708	56	,	,	PUNCT
eurjchem-2615	708	57	g.	g.	PROPN
eurjchem-2615	708	58	s.	s.	PROPN
eurjchem-2615	708	59	;	;	PUNCT
eurjchem-2615	708	60	almeida	almeida	PROPN
eurjchem-2615	708	61	,	,	PUNCT
eurjchem-2615	708	62	m.	m.	PROPN
eurjchem-2615	708	63	c.	c.	PROPN
eurjchem-2615	708	64	;	;	PUNCT
eurjchem-2615	708	65	cunha	cunha	NOUN
eurjchem-2615	708	66	,	,	PUNCT
eurjchem-2615	708	67	a.	a.	PROPN
eurjchem-2615	708	68	c.	c.	PROPN
eurjchem-2615	708	69	synthesis	synthesis	PROPN
eurjchem-2615	708	70	,	,	PUNCT
eurjchem-2615	708	71	antitubercular	antitubercular	ADJ
eurjchem-2615	708	72	activity	activity	NOUN
eurjchem-2615	708	73	,	,	PUNCT
eurjchem-2615	708	74	and	and	CCONJ
eurjchem-2615	708	75	sar	sar	PROPN
eurjchem-2615	708	76	study	study	PROPN
eurjchem-2615	708	77	of	of	ADP
eurjchem-2615	708	78	n	n	CCONJ
eurjchem-2615	708	79	-	-	PUNCT
eurjchem-2615	708	80	substituted	substitute	VERB
eurjchem-2615	708	81	-	-	PUNCT
eurjchem-2615	708	82	phenylamino5	phenylamino5	NOUN
eurjchem-2615	708	83	-	-	PUNCT
eurjchem-2615	708	84	methyl-1h-1,2,3	methyl-1h-1,2,3	NOUN
eurjchem-2615	708	85	-	-	PUNCT
eurjchem-2615	708	86	triazole-4	triazole-4	NOUN
eurjchem-2615	708	87	-	-	PUNCT
eurjchem-2615	708	88	carbohydrazides	carbohydrazide	NOUN
eurjchem-2615	708	89	.	.	PUNCT
eurjchem-2615	709	1	bioorg	bioorg	PROPN
eurjchem-2615	709	2	.	.	PUNCT
eurjchem-2615	710	1	med	med	PROPN
eurjchem-2615	710	2	.	.	PROPN
eurjchem-2615	710	3	chem	chem	PROPN
eurjchem-2615	710	4	.	.	PUNCT
eurjchem-2615	711	1	2011	2011	NUM
eurjchem-2615	711	2	,	,	PUNCT
eurjchem-2615	711	3	19	19	NUM
eurjchem-2615	711	4	(	(	PUNCT
eurjchem-2615	711	5	18	18	NUM
eurjchem-2615	711	6	)	)	PUNCT
eurjchem-2615	711	7	,	,	PUNCT
eurjchem-2615	711	8	5605–5611	5605–5611	NUM
eurjchem-2615	711	9	.	.	PUNCT
eurjchem-2615	712	1	[	[	X
eurjchem-2615	712	2	89	89	NUM
eurjchem-2615	712	3	]	]	PUNCT
eurjchem-2615	712	4	.	.	PUNCT
eurjchem-2615	713	1	yempala	yempala	NOUN
eurjchem-2615	713	2	,	,	PUNCT
eurjchem-2615	713	3	t.	t.	PROPN
eurjchem-2615	713	4	;	;	PUNCT
eurjchem-2615	713	5	sridevi	sridevi	PROPN
eurjchem-2615	713	6	,	,	PUNCT
eurjchem-2615	713	7	j.	j.	PROPN
eurjchem-2615	713	8	p.	p.	PROPN
eurjchem-2615	713	9	;	;	PUNCT
eurjchem-2615	713	10	yogeeswari	yogeeswari	PROPN
eurjchem-2615	713	11	,	,	PUNCT
eurjchem-2615	713	12	p.	p.	PROPN
eurjchem-2615	713	13	;	;	PUNCT
eurjchem-2615	713	14	sriram	sriram	PROPN
eurjchem-2615	713	15	,	,	PUNCT
eurjchem-2615	713	16	d.	d.	PROPN
eurjchem-2615	713	17	;	;	PUNCT
eurjchem-2615	713	18	kantevari	kantevari	PROPN
eurjchem-2615	713	19	,	,	PUNCT
eurjchem-2615	713	20	s.	s.	PROPN
eurjchem-2615	713	21	rational	rational	ADJ
eurjchem-2615	713	22	design	design	NOUN
eurjchem-2615	713	23	and	and	CCONJ
eurjchem-2615	713	24	synthesis	synthesis	NOUN
eurjchem-2615	713	25	of	of	ADP
eurjchem-2615	713	26	novel	novel	ADJ
eurjchem-2615	713	27	dibenzo[b	dibenzo[b	NOUN
eurjchem-2615	713	28	,	,	PUNCT
eurjchem-2615	713	29	d]furan-1,2,3triazole	d]furan-1,2,3triazole	ADJ
eurjchem-2615	713	30	conjugates	conjugate	NOUN
eurjchem-2615	713	31	as	as	ADP
eurjchem-2615	713	32	potent	potent	ADJ
eurjchem-2615	713	33	inhibitors	inhibitor	NOUN
eurjchem-2615	713	34	of	of	ADP
eurjchem-2615	713	35	mycobacterium	mycobacterium	NOUN
eurjchem-2615	713	36	tuberculosis	tuberculosis	NOUN
eurjchem-2615	713	37	.	.	PUNCT
eurjchem-2615	714	1	eur	eur	PROPN
eurjchem-2615	714	2	.	.	PUNCT
eurjchem-2615	715	1	j.	j.	PROPN
eurjchem-2615	715	2	med	med	PROPN
eurjchem-2615	715	3	.	.	PROPN
eurjchem-2615	715	4	chem	chem	PROPN
eurjchem-2615	715	5	.	.	PUNCT
eurjchem-2615	716	1	2014	2014	NUM
eurjchem-2615	716	2	,	,	PUNCT
eurjchem-2615	716	3	71	71	NUM
eurjchem-2615	716	4	,	,	PUNCT
eurjchem-2615	716	5	160–167	160–167	NUM
eurjchem-2615	716	6	.	.	PUNCT
eurjchem-2615	717	1	[	[	X
eurjchem-2615	717	2	90	90	NUM
eurjchem-2615	717	3	]	]	PUNCT
eurjchem-2615	717	4	.	.	PUNCT
eurjchem-2615	718	1	mcmurry	mcmurry	PROPN
eurjchem-2615	718	2	,	,	PUNCT
eurjchem-2615	718	3	l.	l.	PROPN
eurjchem-2615	718	4	m.	m.	PROPN
eurjchem-2615	718	5	;	;	PUNCT
eurjchem-2615	718	6	mcdermott	mcdermott	PROPN
eurjchem-2615	718	7	,	,	PUNCT
eurjchem-2615	718	8	p.	p.	PROPN
eurjchem-2615	718	9	f.	f.	PROPN
eurjchem-2615	718	10	;	;	PUNCT
eurjchem-2615	718	11	levy	levy	NOUN
eurjchem-2615	718	12	,	,	PUNCT
eurjchem-2615	718	13	s.	s.	PROPN
eurjchem-2615	718	14	b.	b.	PROPN
eurjchem-2615	719	1	genetic	genetic	ADJ
eurjchem-2615	719	2	evidence	evidence	NOUN
eurjchem-2615	719	3	that	that	SCONJ
eurjchem-2615	719	4	inha	inha	NOUN
eurjchem-2615	719	5	of	of	ADP
eurjchem-2615	719	6	mycobacterium	mycobacterium	PROPN
eurjchem-2615	719	7	smegmatis	smegmatis	PROPN
eurjchem-2615	719	8	is	be	AUX
eurjchem-2615	719	9	a	a	DET
eurjchem-2615	719	10	target	target	NOUN
eurjchem-2615	719	11	for	for	ADP
eurjchem-2615	719	12	triclosan	triclosan	NOUN
eurjchem-2615	719	13	.	.	PUNCT
eurjchem-2615	720	1	antimicrob	antimicrob	PROPN
eurjchem-2615	720	2	.	.	PUNCT
eurjchem-2615	721	1	agents	agents	PROPN
eurjchem-2615	721	2	chemother	chemother	PROPN
eurjchem-2615	721	3	.	.	PUNCT
eurjchem-2615	722	1	1999	1999	NUM
eurjchem-2615	722	2	,	,	PUNCT
eurjchem-2615	722	3	43	43	NUM
eurjchem-2615	722	4	(	(	PUNCT
eurjchem-2615	722	5	3	3	NUM
eurjchem-2615	722	6	)	)	PUNCT
eurjchem-2615	722	7	,	,	PUNCT
eurjchem-2615	722	8	711–713	711–713	NUM
eurjchem-2615	722	9	.	.	PUNCT
eurjchem-2615	723	1	[	[	X
eurjchem-2615	723	2	91	91	NUM
eurjchem-2615	723	3	]	]	PUNCT
eurjchem-2615	723	4	.	.	PUNCT
eurjchem-2615	724	1	menendez	menendez	PROPN
eurjchem-2615	724	2	,	,	PUNCT
eurjchem-2615	724	3	c.	c.	PROPN
eurjchem-2615	724	4	;	;	PUNCT
eurjchem-2615	724	5	chollet	chollet	NOUN
eurjchem-2615	724	6	,	,	PUNCT
eurjchem-2615	724	7	a.	a.	NOUN
eurjchem-2615	724	8	;	;	PUNCT
eurjchem-2615	724	9	rodriguez	rodriguez	PROPN
eurjchem-2615	724	10	,	,	PUNCT
eurjchem-2615	724	11	f.	f.	PROPN
eurjchem-2615	724	12	;	;	PUNCT
eurjchem-2615	724	13	inard	inard	ADV
eurjchem-2615	724	14	,	,	PUNCT
eurjchem-2615	724	15	c.	c.	NOUN
eurjchem-2615	724	16	;	;	PUNCT
eurjchem-2615	724	17	pasca	pasca	NOUN
eurjchem-2615	724	18	,	,	PUNCT
eurjchem-2615	724	19	m.	m.	NOUN
eurjchem-2615	724	20	r.	r.	PROPN
eurjchem-2615	724	21	;	;	PUNCT
eurjchem-2615	724	22	lherbet	lherbet	PROPN
eurjchem-2615	724	23	,	,	PUNCT
eurjchem-2615	724	24	c.	c.	PROPN
eurjchem-2615	724	25	;	;	PUNCT
eurjchem-2615	724	26	baltas	balta	NOUN
eurjchem-2615	724	27	,	,	PUNCT
eurjchem-2615	724	28	m.	m.	NOUN
eurjchem-2615	724	29	chemical	chemical	NOUN
eurjchem-2615	724	30	synthesis	synthesis	NOUN
eurjchem-2615	724	31	and	and	CCONJ
eurjchem-2615	724	32	biological	biological	ADJ
eurjchem-2615	724	33	evaluation	evaluation	NOUN
eurjchem-2615	724	34	of	of	ADP
eurjchem-2615	724	35	triazole	triazole	NOUN
eurjchem-2615	724	36	derivatives	derivative	NOUN
eurjchem-2615	724	37	as	as	ADP
eurjchem-2615	724	38	inhibitors	inhibitor	NOUN
eurjchem-2615	724	39	of	of	ADP
eurjchem-2615	724	40	inha	inha	NOUN
eurjchem-2615	724	41	and	and	CCONJ
eurjchem-2615	724	42	antituberculosis	antituberculosis	PROPN
eurjchem-2615	724	43	agents	agent	NOUN
eurjchem-2615	724	44	.	.	PUNCT
eurjchem-2615	725	1	eur	eur	PROPN
eurjchem-2615	725	2	.	.	PUNCT
eurjchem-2615	726	1	j.	j.	PROPN
eurjchem-2615	726	2	med	med	PROPN
eurjchem-2615	726	3	.	.	PROPN
eurjchem-2615	726	4	chem	chem	PROPN
eurjchem-2615	726	5	.	.	PUNCT
eurjchem-2615	727	1	2012	2012	NUM
eurjchem-2615	727	2	,	,	PUNCT
eurjchem-2615	727	3	52	52	NUM
eurjchem-2615	727	4	,	,	PUNCT
eurjchem-2615	727	5	275–283	275–283	NUM
eurjchem-2615	727	6	.	.	PUNCT
eurjchem-2615	728	1	[	[	X
eurjchem-2615	728	2	92	92	NUM
eurjchem-2615	728	3	]	]	PUNCT
eurjchem-2615	728	4	.	.	PUNCT
eurjchem-2615	729	1	shanmugavelan	shanmugavelan	PROPN
eurjchem-2615	729	2	,	,	PUNCT
eurjchem-2615	729	3	p.	p.	NOUN
eurjchem-2615	729	4	;	;	PUNCT
eurjchem-2615	729	5	nagarajan	nagarajan	PROPN
eurjchem-2615	729	6	,	,	PUNCT
eurjchem-2615	729	7	s.	s.	PROPN
eurjchem-2615	729	8	;	;	PUNCT
eurjchem-2615	729	9	sathishkumar	sathishkumar	PROPN
eurjchem-2615	729	10	,	,	PUNCT
eurjchem-2615	729	11	m.	m.	NOUN
eurjchem-2615	729	12	;	;	PUNCT
eurjchem-2615	729	13	ponnuswamy	ponnuswamy	NOUN
eurjchem-2615	729	14	,	,	PUNCT
eurjchem-2615	729	15	a.	a.	NOUN
eurjchem-2615	729	16	;	;	PUNCT
eurjchem-2615	729	17	yogeeswari	yogeeswari	PROPN
eurjchem-2615	729	18	,	,	PUNCT
eurjchem-2615	729	19	p.	p.	PROPN
eurjchem-2615	729	20	;	;	PUNCT
eurjchem-2615	729	21	sriram	sriram	PROPN
eurjchem-2615	729	22	,	,	PUNCT
eurjchem-2615	729	23	d.	d.	PROPN
eurjchem-2615	729	24	efficient	efficient	ADJ
eurjchem-2615	729	25	synthesis	synthesis	NOUN
eurjchem-2615	729	26	and	and	CCONJ
eurjchem-2615	729	27	in	in	ADP
eurjchem-2615	729	28	vitro	vitro	X
eurjchem-2615	729	29	antitubercular	antitubercular	ADJ
eurjchem-2615	729	30	activity	activity	NOUN
eurjchem-2615	729	31	of	of	ADP
eurjchem-2615	729	32	1,2,3	1,2,3	NUM
eurjchem-2615	729	33	-	-	PUNCT
eurjchem-2615	729	34	triazoles	triazole	NOUN
eurjchem-2615	729	35	as	as	ADP
eurjchem-2615	729	36	inhibitors	inhibitor	NOUN
eurjchem-2615	729	37	of	of	ADP
eurjchem-2615	729	38	mycobacterium	mycobacterium	NOUN
eurjchem-2615	729	39	tuberculosis	tuberculosis	NOUN
eurjchem-2615	729	40	.	.	PUNCT
eurjchem-2615	730	1	bioorg	bioorg	PROPN
eurjchem-2615	730	2	.	.	PUNCT
eurjchem-2615	731	1	amp	amp	PROPN
eurjchem-2615	731	2	;	;	PUNCT
eurjchem-2615	731	3	med	med	PROPN
eurjchem-2615	731	4	.	.	PROPN
eurjchem-2615	731	5	chem	chem	PROPN
eurjchem-2615	731	6	.	.	PUNCT
eurjchem-2615	732	1	lett	lett	PROPN
eurjchem-2615	732	2	.	.	PUNCT
eurjchem-2615	733	1	2011	2011	NUM
eurjchem-2615	733	2	,	,	PUNCT
eurjchem-2615	733	3	21	21	NUM
eurjchem-2615	733	4	(	(	PUNCT
eurjchem-2615	733	5	24	24	NUM
eurjchem-2615	733	6	)	)	PUNCT
eurjchem-2615	733	7	,	,	PUNCT
eurjchem-2615	733	8	7273–7276	7273–7276	NOUN
eurjchem-2615	733	9	.	.	PUNCT
eurjchem-2615	734	1	[	[	X
eurjchem-2615	734	2	93	93	NUM
eurjchem-2615	734	3	]	]	PUNCT
eurjchem-2615	734	4	.	.	PUNCT
eurjchem-2615	734	5	patpi	patpi	NOUN
eurjchem-2615	734	6	,	,	PUNCT
eurjchem-2615	734	7	s.	s.	PROPN
eurjchem-2615	734	8	r.	r.	PROPN
eurjchem-2615	734	9	;	;	PUNCT
eurjchem-2615	734	10	pulipati	pulipati	PROPN
eurjchem-2615	734	11	,	,	PUNCT
eurjchem-2615	734	12	l.	l.	PROPN
eurjchem-2615	734	13	;	;	PUNCT
eurjchem-2615	734	14	yogeeswari	yogeeswari	PROPN
eurjchem-2615	734	15	,	,	PUNCT
eurjchem-2615	734	16	p.	p.	PROPN
eurjchem-2615	734	17	;	;	PUNCT
eurjchem-2615	734	18	sriram	sriram	PROPN
eurjchem-2615	734	19	,	,	PUNCT
eurjchem-2615	734	20	d.	d.	PROPN
eurjchem-2615	734	21	;	;	PUNCT
eurjchem-2615	734	22	jain	jain	PROPN
eurjchem-2615	734	23	,	,	PUNCT
eurjchem-2615	734	24	n.	n.	PROPN
eurjchem-2615	734	25	;	;	PUNCT
eurjchem-2615	734	26	sridhar	sridhar	PROPN
eurjchem-2615	734	27	,	,	PUNCT
eurjchem-2615	734	28	b.	b.	PROPN
eurjchem-2615	734	29	;	;	PUNCT
eurjchem-2615	734	30	murthy	murthy	PROPN
eurjchem-2615	734	31	,	,	PUNCT
eurjchem-2615	734	32	r.	r.	PROPN
eurjchem-2615	734	33	;	;	PUNCT
eurjchem-2615	734	34	t	t	PROPN
eurjchem-2615	734	35	,	,	PUNCT
eurjchem-2615	734	36	a.	a.	PROPN
eurjchem-2615	734	37	d.	d.	PROPN
eurjchem-2615	734	38	;	;	PUNCT
eurjchem-2615	734	39	kalivendi	kalivendi	PROPN
eurjchem-2615	734	40	,	,	PUNCT
eurjchem-2615	734	41	s.	s.	PROPN
eurjchem-2615	734	42	v.	v.	PROPN
eurjchem-2615	734	43	;	;	PUNCT
eurjchem-2615	734	44	kantevari	kantevari	PROPN
eurjchem-2615	734	45	,	,	PUNCT
eurjchem-2615	734	46	s.	s.	PROPN
eurjchem-2615	734	47	design	design	PROPN
eurjchem-2615	734	48	,	,	PUNCT
eurjchem-2615	734	49	synthesis	synthesis	NOUN
eurjchem-2615	734	50	,	,	PUNCT
eurjchem-2615	734	51	and	and	CCONJ
eurjchem-2615	734	52	structure	structure	NOUN
eurjchem-2615	734	53	–	–	PUNCT
eurjchem-2615	734	54	activity	activity	NOUN
eurjchem-2615	734	55	correlations	correlation	NOUN
eurjchem-2615	734	56	of	of	ADP
eurjchem-2615	734	57	novel	novel	ADJ
eurjchem-2615	734	58	dibenzo[b	dibenzo[b	NOUN
eurjchem-2615	734	59	,	,	PUNCT
eurjchem-2615	734	60	d]furan	d]furan	PROPN
eurjchem-2615	734	61	,	,	PUNCT
eurjchem-2615	734	62	dibenzo[b	dibenzo[b	NOUN
eurjchem-2615	734	63	,	,	PUNCT
eurjchem-2615	734	64	d]thiophene	d]thiophene	ADJ
eurjchem-2615	734	65	,	,	PUNCT
eurjchem-2615	734	66	and	and	CCONJ
eurjchem-2615	734	67	n	n	CCONJ
eurjchem-2615	734	68	-	-	PUNCT
eurjchem-2615	734	69	methylcarbazole	methylcarbazole	NOUN
eurjchem-2615	734	70	clubbed	club	VERB
eurjchem-2615	734	71	1,2,3triazoles	1,2,3triazoles	NUM
eurjchem-2615	734	72	as	as	ADP
eurjchem-2615	734	73	potent	potent	ADJ
eurjchem-2615	734	74	inhibitors	inhibitor	NOUN
eurjchem-2615	734	75	of	of	ADP
eurjchem-2615	734	76	mycobacterium	mycobacterium	NOUN
eurjchem-2615	734	77	tuberculosis	tuberculosis	NOUN
eurjchem-2615	734	78	.	.	PUNCT
eurjchem-2615	735	1	j.	j.	PROPN
eurjchem-2615	735	2	med	med	PROPN
eurjchem-2615	735	3	.	.	PROPN
eurjchem-2615	735	4	chem	chem	PROPN
eurjchem-2615	735	5	.	.	PUNCT
eurjchem-2615	736	1	2012	2012	NUM
eurjchem-2615	736	2	,	,	PUNCT
eurjchem-2615	736	3	55	55	NUM
eurjchem-2615	736	4	(	(	PUNCT
eurjchem-2615	736	5	8)	8)	NUM
eurjchem-2615	736	6	,	,	PUNCT
eurjchem-2615	736	7	3911–3922	3911–3922	NUM
eurjchem-2615	736	8	.	.	PUNCT
eurjchem-2615	737	1	[	[	X
eurjchem-2615	737	2	94	94	NUM
eurjchem-2615	737	3	]	]	PUNCT
eurjchem-2615	737	4	.	.	PUNCT
eurjchem-2615	738	1	pulipati	pulipati	PROPN
eurjchem-2615	738	2	,	,	PUNCT
eurjchem-2615	738	3	l.	l.	PROPN
eurjchem-2615	738	4	;	;	PUNCT
eurjchem-2615	738	5	yogeeswari	yogeeswari	PROPN
eurjchem-2615	738	6	,	,	PUNCT
eurjchem-2615	738	7	p.	p.	PROPN
eurjchem-2615	738	8	;	;	PUNCT
eurjchem-2615	738	9	sriram	sriram	PROPN
eurjchem-2615	738	10	,	,	PUNCT
eurjchem-2615	738	11	d.	d.	PROPN
eurjchem-2615	738	12	;	;	PUNCT
eurjchem-2615	738	13	kantevari	kantevari	PROPN
eurjchem-2615	738	14	,	,	PUNCT
eurjchem-2615	738	15	s.	s.	PROPN
eurjchem-2615	738	16	click	click	PROPN
eurjchem-2615	738	17	-	-	PUNCT
eurjchem-2615	738	18	based	base	VERB
eurjchem-2615	738	19	synthesis	synthesis	NOUN
eurjchem-2615	738	20	and	and	CCONJ
eurjchem-2615	738	21	antitubercular	antitubercular	ADJ
eurjchem-2615	738	22	evaluation	evaluation	NOUN
eurjchem-2615	738	23	of	of	ADP
eurjchem-2615	738	24	novel	novel	ADJ
eurjchem-2615	738	25	dibenzo	dibenzo	NOUN
eurjchem-2615	738	26	[	[	PUNCT
eurjchem-2615	738	27	b	b	NOUN
eurjchem-2615	738	28	,	,	PUNCT
eurjchem-2615	738	29	d	d	X
eurjchem-2615	738	30	]	]	X
eurjchem-2615	738	31	thiophene-1,2,3	thiophene-1,2,3	NOUN
eurjchem-2615	738	32	-	-	PUNCT
eurjchem-2615	738	33	triazoles	triazole	NOUN
eurjchem-2615	738	34	with	with	ADP
eurjchem-2615	738	35	piperidine	piperidine	NOUN
eurjchem-2615	738	36	,	,	PUNCT
eurjchem-2615	738	37	piperazine	piperazine	NOUN
eurjchem-2615	738	38	,	,	PUNCT
eurjchem-2615	738	39	morpholine	morpholine	ADJ
eurjchem-2615	738	40	and	and	CCONJ
eurjchem-2615	738	41	thiomorpholine	thiomorpholine	NOUN
eurjchem-2615	738	42	appendages	appendage	NOUN
eurjchem-2615	738	43	.	.	PUNCT
eurjchem-2615	739	1	bioorg	bioorg	VERB
eurjchem-2615	739	2	.	.	PUNCT
eurjchem-2615	740	1	med	med	PROPN
eurjchem-2615	740	2	.	.	PROPN
eurjchem-2615	740	3	chem	chem	PROPN
eurjchem-2615	740	4	.	.	PUNCT
eurjchem-2615	741	1	lett	lett	PROPN
eurjchem-2615	741	2	.	.	PROPN
eurjchem-2615	742	1	2016	2016	NUM
eurjchem-2615	742	2	,	,	PUNCT
eurjchem-2615	742	3	26	26	NUM
eurjchem-2615	742	4	(	(	PUNCT
eurjchem-2615	742	5	11	11	NUM
eurjchem-2615	742	6	)	)	PUNCT
eurjchem-2615	742	7	,	,	PUNCT
eurjchem-2615	742	8	2649–2654	2649–2654	NUM
eurjchem-2615	742	9	.	.	PUNCT
eurjchem-2615	743	1	[	[	X
eurjchem-2615	743	2	95	95	NUM
eurjchem-2615	743	3	]	]	PUNCT
eurjchem-2615	743	4	.	.	PUNCT
eurjchem-2615	744	1	shaikh	shaikh	PROPN
eurjchem-2615	744	2	,	,	PUNCT
eurjchem-2615	744	3	m.	m.	PROPN
eurjchem-2615	744	4	h.	h.	PROPN
eurjchem-2615	744	5	;	;	PUNCT
eurjchem-2615	744	6	subhedar	subhedar	ADV
eurjchem-2615	744	7	,	,	PUNCT
eurjchem-2615	744	8	d.	d.	PROPN
eurjchem-2615	744	9	d.	d.	PROPN
eurjchem-2615	744	10	;	;	PUNCT
eurjchem-2615	744	11	nawale	nawale	PROPN
eurjchem-2615	744	12	,	,	PUNCT
eurjchem-2615	744	13	l.	l.	PROPN
eurjchem-2615	744	14	;	;	PUNCT
eurjchem-2615	744	15	sarkar	sarkar	PROPN
eurjchem-2615	744	16	,	,	PUNCT
eurjchem-2615	744	17	d.	d.	PROPN
eurjchem-2615	744	18	;	;	PUNCT
eurjchem-2615	744	19	kalam	kalam	PROPN
eurjchem-2615	744	20	khan	khan	PROPN
eurjchem-2615	744	21	,	,	PUNCT
eurjchem-2615	744	22	f.	f.	PROPN
eurjchem-2615	744	23	a.	a.	PROPN
eurjchem-2615	744	24	;	;	PUNCT
eurjchem-2615	744	25	sangshetti	sangshetti	PROPN
eurjchem-2615	744	26	,	,	PUNCT
eurjchem-2615	744	27	j.	j.	PROPN
eurjchem-2615	744	28	n.	n.	PROPN
eurjchem-2615	744	29	;	;	PUNCT
eurjchem-2615	744	30	shingate	shingate	VERB
eurjchem-2615	744	31	,	,	PUNCT
eurjchem-2615	744	32	b.	b.	PROPN
eurjchem-2615	744	33	b.	b.	PROPN
eurjchem-2615	745	1	1,2,3	1,2,3	NUM
eurjchem-2615	745	2	-	-	ADJ
eurjchem-2615	745	3	triazole	triazole	ADJ
eurjchem-2615	745	4	derivatives	derivative	NOUN
eurjchem-2615	745	5	as	as	ADP
eurjchem-2615	745	6	antitubercular	antitubercular	ADJ
eurjchem-2615	745	7	agents	agent	NOUN
eurjchem-2615	745	8	:	:	PUNCT
eurjchem-2615	745	9	synthesis	synthesis	NOUN
eurjchem-2615	745	10	,	,	PUNCT
eurjchem-2615	745	11	biological	biological	ADJ
eurjchem-2615	745	12	evaluation	evaluation	NOUN
eurjchem-2615	745	13	and	and	CCONJ
eurjchem-2615	745	14	molecular	molecular	ADJ
eurjchem-2615	745	15	docking	docking	NOUN
eurjchem-2615	745	16	study	study	NOUN
eurjchem-2615	745	17	.	.	PUNCT
eurjchem-2615	746	1	med	med	PROPN
eurjchem-2615	746	2	.	.	PROPN
eurjchem-2615	746	3	chem	chem	PROPN
eurjchem-2615	746	4	.	.	PUNCT
eurjchem-2615	747	1	commun	commun	PROPN
eurjchem-2615	747	2	.	.	PROPN
eurjchem-2615	748	1	2015	2015	NUM
eurjchem-2615	748	2	,	,	PUNCT
eurjchem-2615	748	3	6	6	NUM
eurjchem-2615	748	4	(	(	PUNCT
eurjchem-2615	748	5	6	6	NUM
eurjchem-2615	748	6	)	)	PUNCT
eurjchem-2615	748	7	,	,	PUNCT
eurjchem-2615	748	8	1104–1116	1104–1116	NUM
eurjchem-2615	748	9	.	.	PUNCT
eurjchem-2615	749	1	[	[	X
eurjchem-2615	749	2	96	96	NUM
eurjchem-2615	749	3	]	]	SYM
eurjchem-2615	749	4	.	.	PUNCT
eurjchem-2615	750	1	alghamdi	alghamdi	PROPN
eurjchem-2615	750	2	,	,	PUNCT
eurjchem-2615	750	3	w.	w.	PROPN
eurjchem-2615	750	4	a.	a.	PROPN
eurjchem-2615	750	5	;	;	PUNCT
eurjchem-2615	750	6	al	al	PROPN
eurjchem-2615	750	7	-	-	PUNCT
eurjchem-2615	750	8	shaer	shaer	PROPN
eurjchem-2615	750	9	,	,	PUNCT
eurjchem-2615	750	10	m.	m.	PROPN
eurjchem-2615	750	11	h.	h.	PROPN
eurjchem-2615	750	12	;	;	PUNCT
eurjchem-2615	750	13	an	an	DET
eurjchem-2615	750	14	,	,	PUNCT
eurjchem-2615	750	15	g.	g.	PROPN
eurjchem-2615	750	16	;	;	PUNCT
eurjchem-2615	750	17	alsultan	alsultan	PROPN
eurjchem-2615	750	18	,	,	PUNCT
eurjchem-2615	750	19	a.	a.	NOUN
eurjchem-2615	750	20	;	;	PUNCT
eurjchem-2615	750	21	kipiani	kipiani	PROPN
eurjchem-2615	750	22	,	,	PUNCT
eurjchem-2615	750	23	m.	m.	NOUN
eurjchem-2615	750	24	;	;	PUNCT
eurjchem-2615	750	25	barbakadze	barbakadze	PROPN
eurjchem-2615	750	26	,	,	PUNCT
eurjchem-2615	750	27	k.	k.	PROPN
eurjchem-2615	750	28	;	;	PUNCT
eurjchem-2615	750	29	mikiashvili	mikiashvili	NOUN
eurjchem-2615	750	30	,	,	PUNCT
eurjchem-2615	750	31	l.	l.	PROPN
eurjchem-2615	750	32	;	;	PUNCT
eurjchem-2615	750	33	ashkin	ashkin	PROPN
eurjchem-2615	750	34	,	,	PUNCT
eurjchem-2615	750	35	d.	d.	PROPN
eurjchem-2615	750	36	;	;	PUNCT
eurjchem-2615	750	37	griffith	griffith	PROPN
eurjchem-2615	750	38	,	,	PUNCT
eurjchem-2615	750	39	d.	d.	PROPN
eurjchem-2615	750	40	e.	e.	PROPN
eurjchem-2615	750	41	;	;	PUNCT
eurjchem-2615	750	42	cegielski	cegielski	PROPN
eurjchem-2615	750	43	,	,	PUNCT
eurjchem-2615	750	44	j.	j.	PROPN
eurjchem-2615	750	45	p.	p.	PROPN
eurjchem-2615	750	46	;	;	PUNCT
eurjchem-2615	750	47	kempker	kempker	PROPN
eurjchem-2615	750	48	,	,	PUNCT
eurjchem-2615	750	49	r.	r.	PROPN
eurjchem-2615	750	50	r.	r.	PROPN
eurjchem-2615	750	51	;	;	PUNCT
eurjchem-2615	750	52	peloquin	peloquin	NOUN
eurjchem-2615	750	53	,	,	PUNCT
eurjchem-2615	750	54	c.	c.	PROPN
eurjchem-2615	750	55	a.	a.	NOUN
eurjchem-2615	750	56	population	population	NOUN
eurjchem-2615	750	57	pharmacokinetics	pharmacokinetic	NOUN
eurjchem-2615	750	58	of	of	ADP
eurjchem-2615	750	59	linezolid	linezolid	NOUN
eurjchem-2615	750	60	in	in	ADP
eurjchem-2615	750	61	tuberculosis	tuberculosis	NOUN
eurjchem-2615	750	62	patients	patient	NOUN
eurjchem-2615	750	63	:	:	PUNCT
eurjchem-2615	750	64	dosing	dose	VERB
eurjchem-2615	750	65	regimen	regimen	NOUN
eurjchem-2615	750	66	simulation	simulation	NOUN
eurjchem-2615	750	67	and	and	CCONJ
eurjchem-2615	750	68	target	target	VERB
eurjchem-2615	750	69	attainment	attainment	ADJ
eurjchem-2615	750	70	analysis	analysis	NOUN
eurjchem-2615	750	71	.	.	PUNCT
eurjchem-2615	751	1	antimicrob	antimicrob	PROPN
eurjchem-2615	751	2	.	.	PUNCT
eurjchem-2615	752	1	agents	agents	PROPN
eurjchem-2615	752	2	chemother	chemother	PROPN
eurjchem-2615	752	3	.	.	PUNCT
eurjchem-2615	753	1	2020	2020	NUM
eurjchem-2615	753	2	,	,	PUNCT
eurjchem-2615	753	3	64	64	NUM
eurjchem-2615	753	4	(	(	PUNCT
eurjchem-2615	753	5	10	10	NUM
eurjchem-2615	753	6	)	)	PUNCT
eurjchem-2615	753	7	,	,	PUNCT
eurjchem-2615	753	8	https://doi.org/10.1128/aac.01174–20	https://doi.org/10.1128/aac.01174–20	ADJ
eurjchem-2615	753	9	.	.	PUNCT
eurjchem-2615	754	1	[	[	X
eurjchem-2615	754	2	97	97	NUM
eurjchem-2615	754	3	]	]	PUNCT
eurjchem-2615	754	4	.	.	PUNCT
eurjchem-2615	755	1	bhattarai	bhattarai	PROPN
eurjchem-2615	755	2	,	,	PUNCT
eurjchem-2615	755	3	d.	d.	PROPN
eurjchem-2615	755	4	;	;	PUNCT
eurjchem-2615	755	5	lee	lee	PROPN
eurjchem-2615	755	6	,	,	PUNCT
eurjchem-2615	755	7	s.	s.	PROPN
eurjchem-2615	755	8	h.	h.	PROPN
eurjchem-2615	755	9	;	;	PUNCT
eurjchem-2615	755	10	seo	seo	PROPN
eurjchem-2615	755	11	,	,	PUNCT
eurjchem-2615	755	12	s.	s.	PROPN
eurjchem-2615	755	13	h.	h.	PROPN
eurjchem-2615	755	14	;	;	PUNCT
eurjchem-2615	755	15	nam	nam	PROPN
eurjchem-2615	755	16	,	,	PUNCT
eurjchem-2615	755	17	g.	g.	PROPN
eurjchem-2615	755	18	;	;	PUNCT
eurjchem-2615	755	19	kang	kang	PROPN
eurjchem-2615	755	20	,	,	PUNCT
eurjchem-2615	755	21	s.	s.	PROPN
eurjchem-2615	755	22	b.	b.	PROPN
eurjchem-2615	755	23	;	;	PUNCT
eurjchem-2615	755	24	pae	pae	PROPN
eurjchem-2615	755	25	,	,	PUNCT
eurjchem-2615	755	26	a.	a.	NOUN
eurjchem-2615	755	27	n.	n.	PROPN
eurjchem-2615	755	28	;	;	PUNCT
eurjchem-2615	755	29	kim	kim	PROPN
eurjchem-2615	755	30	,	,	PUNCT
eurjchem-2615	755	31	e.	e.	PROPN
eurjchem-2615	755	32	e.	e.	PROPN
eurjchem-2615	755	33	;	;	PUNCT
eurjchem-2615	755	34	oh	oh	INTJ
eurjchem-2615	755	35	,	,	PUNCT
eurjchem-2615	755	36	t.	t.	PROPN
eurjchem-2615	755	37	;	;	PUNCT
eurjchem-2615	755	38	cho	cho	PROPN
eurjchem-2615	755	39	,	,	PUNCT
eurjchem-2615	755	40	s.	s.	PROPN
eurjchem-2615	755	41	;	;	PUNCT
eurjchem-2615	755	42	keum	keum	PROPN
eurjchem-2615	755	43	,	,	PUNCT
eurjchem-2615	755	44	g.	g.	NOUN
eurjchem-2615	755	45	synthesis	synthesis	NOUN
eurjchem-2615	755	46	and	and	CCONJ
eurjchem-2615	755	47	in	in	ADP
eurjchem-2615	755	48	vitro	vitro	X
eurjchem-2615	755	49	antibacterial	antibacterial	ADJ
eurjchem-2615	755	50	activity	activity	NOUN
eurjchem-2615	755	51	of	of	ADP
eurjchem-2615	755	52	novel	novel	ADJ
eurjchem-2615	755	53	3	3	NUM
eurjchem-2615	755	54	-	-	PUNCT
eurjchem-2615	755	55	azabicyclo[3.3.0]octanyl	azabicyclo[3.3.0]octanyl	ADJ
eurjchem-2615	755	56	oxazolidinones	oxazolidinone	NOUN
eurjchem-2615	755	57	.	.	PUNCT
eurjchem-2615	756	1	chem	chem	NOUN
eurjchem-2615	756	2	.	.	PUNCT
eurjchem-2615	757	1	biol	biol	PROPN
eurjchem-2615	757	2	.	.	PUNCT
eurjchem-2615	758	1	drug	drug	NOUN
eurjchem-2615	758	2	.	.	PUNCT
eurjchem-2615	759	1	des	des	PROPN
eurjchem-2615	759	2	.	.	PROPN
eurjchem-2615	759	3	2012	2012	NUM
eurjchem-2615	759	4	,	,	PUNCT
eurjchem-2615	759	5	80	80	NUM
eurjchem-2615	759	6	(	(	PUNCT
eurjchem-2615	759	7	3	3	NUM
eurjchem-2615	759	8	)	)	PUNCT
eurjchem-2615	759	9	,	,	PUNCT
eurjchem-2615	759	10	388–397	388–397	NUM
eurjchem-2615	759	11	.	.	PUNCT
eurjchem-2615	760	1	[	[	X
eurjchem-2615	760	2	98	98	NUM
eurjchem-2615	760	3	]	]	SYM
eurjchem-2615	760	4	.	.	PUNCT
eurjchem-2615	761	1	kamal	kamal	PROPN
eurjchem-2615	761	2	,	,	PUNCT
eurjchem-2615	761	3	a.	a.	NOUN
eurjchem-2615	761	4	;	;	PUNCT
eurjchem-2615	761	5	swapna	swapna	PROPN
eurjchem-2615	761	6	,	,	PUNCT
eurjchem-2615	761	7	p.	p.	NOUN
eurjchem-2615	761	8	;	;	PUNCT
eurjchem-2615	761	9	shetti	shetti	PROPN
eurjchem-2615	761	10	,	,	PUNCT
eurjchem-2615	761	11	r.	r.	PROPN
eurjchem-2615	761	12	v.	v.	PROPN
eurjchem-2615	761	13	;	;	PUNCT
eurjchem-2615	761	14	shaik	shaik	PROPN
eurjchem-2615	761	15	,	,	PUNCT
eurjchem-2615	761	16	a.	a.	PROPN
eurjchem-2615	761	17	b.	b.	PROPN
eurjchem-2615	761	18	;	;	PUNCT
eurjchem-2615	761	19	narasimha	narasimha	PROPN
eurjchem-2615	761	20	rao	rao	PROPN
eurjchem-2615	761	21	,	,	PUNCT
eurjchem-2615	761	22	m.	m.	NOUN
eurjchem-2615	761	23	;	;	PUNCT
eurjchem-2615	761	24	sultana	sultana	NOUN
eurjchem-2615	761	25	,	,	PUNCT
eurjchem-2615	761	26	f.	f.	PROPN
eurjchem-2615	761	27	;	;	PUNCT
eurjchem-2615	761	28	khan	khan	PROPN
eurjchem-2615	761	29	,	,	PUNCT
eurjchem-2615	761	30	i.	i.	PROPN
eurjchem-2615	761	31	a.	a.	PROPN
eurjchem-2615	761	32	;	;	PUNCT
eurjchem-2615	761	33	sharma	sharma	PROPN
eurjchem-2615	761	34	,	,	PUNCT
eurjchem-2615	761	35	s.	s.	PROPN
eurjchem-2615	761	36	;	;	PUNCT
eurjchem-2615	761	37	kalia	kalia	NOUN
eurjchem-2615	761	38	,	,	PUNCT
eurjchem-2615	761	39	n.	n.	PROPN
eurjchem-2615	761	40	p.	p.	PROPN
eurjchem-2615	761	41	;	;	PUNCT
eurjchem-2615	761	42	kumar	kumar	PROPN
eurjchem-2615	761	43	,	,	PUNCT
eurjchem-2615	761	44	s.	s.	PROPN
eurjchem-2615	761	45	;	;	PUNCT
eurjchem-2615	761	46	chandrakant	chandrakant	PROPN
eurjchem-2615	761	47	,	,	PUNCT
eurjchem-2615	761	48	b.	b.	PROPN
eurjchem-2615	761	49	anti	anti	ADJ
eurjchem-2615	761	50	-	-	ADJ
eurjchem-2615	761	51	tubercular	tubercular	ADJ
eurjchem-2615	761	52	agents	agent	NOUN
eurjchem-2615	761	53	.	.	PUNCT
eurjchem-2615	762	1	part	part	NOUN
eurjchem-2615	762	2	7	7	NUM
eurjchem-2615	762	3	:	:	PUNCT
eurjchem-2615	762	4	a	a	DET
eurjchem-2615	762	5	new	new	ADJ
eurjchem-2615	762	6	class	class	NOUN
eurjchem-2615	762	7	of	of	ADP
eurjchem-2615	762	8	diarylpyrrole	diarylpyrrole	ADJ
eurjchem-2615	762	9	–	–	PUNCT
eurjchem-2615	762	10	oxazolidinone	oxazolidinone	NOUN
eurjchem-2615	762	11	conjugates	conjugate	NOUN
eurjchem-2615	762	12	as	as	ADP
eurjchem-2615	762	13	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	762	14	agents	agent	NOUN
eurjchem-2615	762	15	.	.	PUNCT
eurjchem-2615	763	1	eur	eur	PROPN
eurjchem-2615	763	2	.	.	PUNCT
eurjchem-2615	764	1	j.	j.	PROPN
eurjchem-2615	764	2	med	med	PROPN
eurjchem-2615	764	3	.	.	PROPN
eurjchem-2615	764	4	chem	chem	PROPN
eurjchem-2615	764	5	.	.	PUNCT
eurjchem-2615	765	1	2013	2013	NUM
eurjchem-2615	765	2	,	,	PUNCT
eurjchem-2615	765	3	64	64	NUM
eurjchem-2615	765	4	,	,	PUNCT
eurjchem-2615	765	5	239–251	239–251	NUM
eurjchem-2615	765	6	.	.	PUNCT
eurjchem-2615	766	1	[	[	X
eurjchem-2615	766	2	99	99	NUM
eurjchem-2615	766	3	]	]	PUNCT
eurjchem-2615	766	4	.	.	PUNCT
eurjchem-2615	767	1	kaushik	kaushik	PROPN
eurjchem-2615	767	2	,	,	PUNCT
eurjchem-2615	767	3	c.	c.	PROPN
eurjchem-2615	767	4	;	;	PUNCT
eurjchem-2615	767	5	kumar	kumar	PROPN
eurjchem-2615	767	6	,	,	PUNCT
eurjchem-2615	767	7	k.	k.	PROPN
eurjchem-2615	767	8	;	;	PUNCT
eurjchem-2615	767	9	singh	singh	PROPN
eurjchem-2615	767	10	,	,	PUNCT
eurjchem-2615	767	11	s.	s.	PROPN
eurjchem-2615	767	12	;	;	PUNCT
eurjchem-2615	767	13	singh	singh	PROPN
eurjchem-2615	767	14	,	,	PUNCT
eurjchem-2615	767	15	d.	d.	PROPN
eurjchem-2615	767	16	;	;	PUNCT
eurjchem-2615	767	17	saini	saini	PROPN
eurjchem-2615	767	18	,	,	PUNCT
eurjchem-2615	767	19	s.	s.	PROPN
eurjchem-2615	767	20	synthesis	synthesis	NOUN
eurjchem-2615	767	21	and	and	CCONJ
eurjchem-2615	767	22	antimicrobial	antimicrobial	ADJ
eurjchem-2615	767	23	evaluation	evaluation	NOUN
eurjchem-2615	767	24	of	of	ADP
eurjchem-2615	767	25	1,4	1,4	ADV
eurjchem-2615	767	26	-	-	PUNCT
eurjchem-2615	767	27	disubstituted	disubstitute	VERB
eurjchem-2615	767	28	1,2,3	1,2,3	NUM
eurjchem-2615	767	29	-	-	NOUN
eurjchem-2615	767	30	triazoles	triazole	NOUN
eurjchem-2615	767	31	with	with	ADP
eurjchem-2615	767	32	aromatic	aromatic	ADJ
eurjchem-2615	767	33	ester	ester	NOUN
eurjchem-2615	767	34	functionality	functionality	NOUN
eurjchem-2615	767	35	.	.	PUNCT
eurjchem-2615	768	1	arab	arab	PROPN
eurjchem-2615	768	2	.	.	PUNCT
eurjchem-2615	769	1	j.	j.	PROPN
eurjchem-2615	769	2	chem	chem	PROPN
eurjchem-2615	769	3	.	.	PUNCT
eurjchem-2615	770	1	2016	2016	NUM
eurjchem-2615	770	2	,	,	PUNCT
eurjchem-2615	770	3	9	9	NUM
eurjchem-2615	770	4	(	(	PUNCT
eurjchem-2615	770	5	6	6	NUM
eurjchem-2615	770	6	)	)	PUNCT
eurjchem-2615	770	7	,	,	PUNCT
eurjchem-2615	770	8	865–871	865–871	NUM
eurjchem-2615	770	9	.	.	PUNCT
eurjchem-2615	771	1	[	[	X
eurjchem-2615	771	2	100	100	NUM
eurjchem-2615	771	3	]	]	PUNCT
eurjchem-2615	771	4	.	.	PUNCT
eurjchem-2615	772	1	ghiano	ghiano	PROPN
eurjchem-2615	772	2	,	,	PUNCT
eurjchem-2615	772	3	d.	d.	PROPN
eurjchem-2615	772	4	g.	g.	PROPN
eurjchem-2615	772	5	;	;	PUNCT
eurjchem-2615	772	6	de	de	PROPN
eurjchem-2615	772	7	la	la	PROPN
eurjchem-2615	772	8	iglesia	iglesia	PROPN
eurjchem-2615	772	9	,	,	PUNCT
eurjchem-2615	772	10	a.	a.	PROPN
eurjchem-2615	772	11	;	;	PUNCT
eurjchem-2615	772	12	liu	liu	PROPN
eurjchem-2615	772	13	,	,	PUNCT
eurjchem-2615	772	14	n.	n.	PROPN
eurjchem-2615	772	15	;	;	PUNCT
eurjchem-2615	772	16	tonge	tonge	ADJ
eurjchem-2615	772	17	,	,	PUNCT
eurjchem-2615	772	18	p.	p.	PROPN
eurjchem-2615	772	19	j.	j.	PROPN
eurjchem-2615	772	20	;	;	PUNCT
eurjchem-2615	772	21	morbidoni	morbidoni	PROPN
eurjchem-2615	772	22	,	,	PUNCT
eurjchem-2615	772	23	h.	h.	PROPN
eurjchem-2615	772	24	r.	r.	PROPN
eurjchem-2615	772	25	;	;	PUNCT
eurjchem-2615	772	26	labadie	labadie	PROPN
eurjchem-2615	772	27	,	,	PUNCT
eurjchem-2615	772	28	g.	g.	PROPN
eurjchem-2615	772	29	r.	r.	PROPN
eurjchem-2615	772	30	antitubercular	antitubercular	ADJ
eurjchem-2615	772	31	activity	activity	NOUN
eurjchem-2615	772	32	of	of	ADP
eurjchem-2615	772	33	1,2,3	1,2,3	NUM
eurjchem-2615	772	34	-	-	PUNCT
eurjchem-2615	772	35	triazolyl	triazolyl	ADJ
eurjchem-2615	772	36	fatty	fatty	NOUN
eurjchem-2615	772	37	acid	acid	NOUN
eurjchem-2615	772	38	derivatives	derivative	NOUN
eurjchem-2615	772	39	.	.	PUNCT
eurjchem-2615	773	1	eur	eur	PROPN
eurjchem-2615	773	2	.	.	PUNCT
eurjchem-2615	774	1	j.	j.	PROPN
eurjchem-2615	774	2	med	med	PROPN
eurjchem-2615	774	3	.	.	PROPN
eurjchem-2615	774	4	chem	chem	PROPN
eurjchem-2615	774	5	.	.	PUNCT
eurjchem-2615	775	1	2017	2017	NUM
eurjchem-2615	775	2	,	,	PUNCT
eurjchem-2615	775	3	125	125	NUM
eurjchem-2615	775	4	,	,	PUNCT
eurjchem-2615	775	5	842–852	842–852	NUM
eurjchem-2615	775	6	.	.	PUNCT
eurjchem-2615	776	1	[	[	X
eurjchem-2615	776	2	101	101	NUM
eurjchem-2615	776	3	]	]	PUNCT
eurjchem-2615	776	4	.	.	PUNCT
eurjchem-2615	777	1	goud	goud	PROPN
eurjchem-2615	777	2	,	,	PUNCT
eurjchem-2615	777	3	g.	g.	PROPN
eurjchem-2615	777	4	l.	l.	PROPN
eurjchem-2615	777	5	;	;	PUNCT
eurjchem-2615	777	6	ramesh	ramesh	PROPN
eurjchem-2615	777	7	,	,	PUNCT
eurjchem-2615	777	8	s.	s.	PROPN
eurjchem-2615	777	9	;	;	PUNCT
eurjchem-2615	777	10	ashok	ashok	PROPN
eurjchem-2615	777	11	,	,	PUNCT
eurjchem-2615	777	12	d.	d.	PROPN
eurjchem-2615	777	13	;	;	PUNCT
eurjchem-2615	777	14	reddy	reddy	PROPN
eurjchem-2615	777	15	,	,	PUNCT
eurjchem-2615	777	16	v.	v.	PROPN
eurjchem-2615	777	17	p.	p.	PROPN
eurjchem-2615	777	18	;	;	PUNCT
eurjchem-2615	777	19	yogeeswari	yogeeswari	PROPN
eurjchem-2615	777	20	,	,	PUNCT
eurjchem-2615	777	21	p.	p.	PROPN
eurjchem-2615	777	22	;	;	PUNCT
eurjchem-2615	777	23	sriram	sriram	PROPN
eurjchem-2615	777	24	,	,	PUNCT
eurjchem-2615	777	25	d.	d.	PROPN
eurjchem-2615	777	26	;	;	PUNCT
eurjchem-2615	777	27	saikrishna	saikrishna	PROPN
eurjchem-2615	777	28	,	,	PUNCT
eurjchem-2615	777	29	b.	b.	PROPN
eurjchem-2615	777	30	;	;	PUNCT
eurjchem-2615	777	31	manga	manga	PROPN
eurjchem-2615	777	32	,	,	PUNCT
eurjchem-2615	777	33	v.	v.	ADP
eurjchem-2615	777	34	design	design	NOUN
eurjchem-2615	777	35	,	,	PUNCT
eurjchem-2615	777	36	synthesis	synthesis	NOUN
eurjchem-2615	777	37	,	,	PUNCT
eurjchem-2615	777	38	molecular	molecular	NOUN
eurjchem-2615	777	39	-	-	PUNCT
eurjchem-2615	777	40	docking	docking	ADJ
eurjchem-2615	777	41	and	and	CCONJ
eurjchem-2615	777	42	antimycobacterial	antimycobacterial	ADJ
eurjchem-2615	777	43	evaluation	evaluation	NOUN
eurjchem-2615	777	44	of	of	ADP
eurjchem-2615	777	45	some	some	DET
eurjchem-2615	777	46	novel	novel	ADJ
eurjchem-2615	777	47	1,2,3	1,2,3	NUM
eurjchem-2615	777	48	-	-	PUNCT
eurjchem-2615	777	49	triazolyl	triazolyl	ADJ
eurjchem-2615	777	50	xanthenones	xanthenone	NOUN
eurjchem-2615	777	51	.	.	PUNCT
eurjchem-2615	778	1	med	med	PROPN
eurjchem-2615	778	2	.	.	PROPN
eurjchem-2615	778	3	chem	chem	PROPN
eurjchem-2615	778	4	.	.	PUNCT
eurjchem-2615	779	1	commun	commun	PROPN
eurjchem-2615	779	2	.	.	PROPN
eurjchem-2615	780	1	2017	2017	NUM
eurjchem-2615	780	2	,	,	PUNCT
eurjchem-2615	780	3	8	8	NUM
eurjchem-2615	780	4	(	(	PUNCT
eurjchem-2615	780	5	3	3	NUM
eurjchem-2615	780	6	)	)	PUNCT
eurjchem-2615	780	7	,	,	PUNCT
eurjchem-2615	780	8	559–570	559–570	NUM
eurjchem-2615	780	9	.	.	PUNCT
eurjchem-2615	781	1	[	[	X
eurjchem-2615	781	2	102	102	NUM
eurjchem-2615	781	3	]	]	PUNCT
eurjchem-2615	781	4	.	.	PUNCT
eurjchem-2615	782	1	danne	danne	PROPN
eurjchem-2615	782	2	,	,	PUNCT
eurjchem-2615	782	3	a.	a.	PROPN
eurjchem-2615	782	4	b.	b.	PROPN
eurjchem-2615	782	5	;	;	PUNCT
eurjchem-2615	782	6	choudhari	choudhari	PROPN
eurjchem-2615	782	7	,	,	PUNCT
eurjchem-2615	782	8	a.	a.	PROPN
eurjchem-2615	782	9	s.	s.	PROPN
eurjchem-2615	782	10	;	;	PUNCT
eurjchem-2615	782	11	chakraborty	chakraborty	PROPN
eurjchem-2615	782	12	,	,	PUNCT
eurjchem-2615	782	13	s.	s.	PROPN
eurjchem-2615	782	14	;	;	PUNCT
eurjchem-2615	782	15	sarkar	sarkar	PROPN
eurjchem-2615	782	16	,	,	PUNCT
eurjchem-2615	782	17	d.	d.	PROPN
eurjchem-2615	782	18	;	;	PUNCT
eurjchem-2615	782	19	khedkar	khedkar	PROPN
eurjchem-2615	782	20	,	,	PUNCT
eurjchem-2615	782	21	v.	v.	ADP
eurjchem-2615	782	22	m.	m.	NOUN
eurjchem-2615	782	23	;	;	PUNCT
eurjchem-2615	782	24	shingate	shingate	VERB
eurjchem-2615	782	25	,	,	PUNCT
eurjchem-2615	782	26	b.	b.	PROPN
eurjchem-2615	782	27	b.	b.	PROPN
eurjchem-2615	782	28	triazole	triazole	PROPN
eurjchem-2615	782	29	–	–	PUNCT
eurjchem-2615	782	30	diindolylmethane	diindolylmethane	NOUN
eurjchem-2615	782	31	conjugates	conjugate	NOUN
eurjchem-2615	782	32	as	as	ADP
eurjchem-2615	782	33	new	new	ADJ
eurjchem-2615	782	34	antitubercular	antitubercular	ADJ
eurjchem-2615	782	35	agents	agent	NOUN
eurjchem-2615	782	36	:	:	PUNCT
eurjchem-2615	782	37	synthesis	synthesis	NOUN
eurjchem-2615	782	38	,	,	PUNCT
eurjchem-2615	782	39	bioevaluation	bioevaluation	NOUN
eurjchem-2615	782	40	,	,	PUNCT
eurjchem-2615	782	41	and	and	CCONJ
eurjchem-2615	782	42	molecular	molecular	ADJ
eurjchem-2615	782	43	docking	docking	NOUN
eurjchem-2615	782	44	.	.	PUNCT
eurjchem-2615	783	1	med	med	PROPN
eurjchem-2615	783	2	.	.	PROPN
eurjchem-2615	783	3	chem	chem	PROPN
eurjchem-2615	783	4	.	.	PUNCT
eurjchem-2615	784	1	commun	commun	PROPN
eurjchem-2615	784	2	.	.	PUNCT
eurjchem-2615	785	1	2018	2018	NUM
eurjchem-2615	785	2	,	,	PUNCT
eurjchem-2615	785	3	9	9	NUM
eurjchem-2615	785	4	(	(	PUNCT
eurjchem-2615	785	5	7	7	NUM
eurjchem-2615	785	6	)	)	PUNCT
eurjchem-2615	785	7	,	,	PUNCT
eurjchem-2615	785	8	1114–1130	1114–1130	NUM
eurjchem-2615	785	9	.	.	PUNCT
eurjchem-2615	786	1	copyright	copyright	NOUN
eurjchem-2615	786	2	©	©	PROPN
eurjchem-2615	786	3	2025	2025	NUM
eurjchem-2615	786	4	by	by	ADP
eurjchem-2615	786	5	authors	author	NOUN
eurjchem-2615	786	6	.	.	PUNCT
eurjchem-2615	787	1	this	this	DET
eurjchem-2615	787	2	work	work	NOUN
eurjchem-2615	787	3	is	be	AUX
eurjchem-2615	787	4	published	publish	VERB
eurjchem-2615	787	5	and	and	CCONJ
eurjchem-2615	787	6	licensed	license	VERB
eurjchem-2615	787	7	by	by	ADP
eurjchem-2615	787	8	atlanta	atlanta	PROPN
eurjchem-2615	787	9	publishing	publishing	PROPN
eurjchem-2615	787	10	house	house	PROPN
eurjchem-2615	787	11	llc	llc	PROPN
eurjchem-2615	787	12	,	,	PUNCT
eurjchem-2615	787	13	atlanta	atlanta	PROPN
eurjchem-2615	787	14	,	,	PUNCT
eurjchem-2615	787	15	ga	ga	PROPN
eurjchem-2615	787	16	,	,	PUNCT
eurjchem-2615	787	17	usa	usa	PROPN
eurjchem-2615	787	18	.	.	PUNCT
eurjchem-2615	788	1	the	the	DET
eurjchem-2615	788	2	full	full	ADJ
eurjchem-2615	788	3	terms	term	NOUN
eurjchem-2615	788	4	of	of	ADP
eurjchem-2615	788	5	this	this	DET
eurjchem-2615	788	6	license	license	NOUN
eurjchem-2615	788	7	are	be	AUX
eurjchem-2615	788	8	available	available	ADJ
eurjchem-2615	788	9	at	at	ADP
eurjchem-2615	788	10	https://www.eurjchem.com/index.php/eurjchem/terms	https://www.eurjchem.com/index.php/eurjchem/term	NOUN
eurjchem-2615	788	11	and	and	CCONJ
eurjchem-2615	788	12	incorporate	incorporate	VERB
eurjchem-2615	788	13	the	the	DET
eurjchem-2615	788	14	creative	creative	ADJ
eurjchem-2615	788	15	commons	common	NOUN
eurjchem-2615	788	16	attribution	attribution	NOUN
eurjchem-2615	788	17	-	-	PUNCT
eurjchem-2615	788	18	non	non	ADJ
eurjchem-2615	788	19	commercial	commercial	NOUN
eurjchem-2615	788	20	(	(	PUNCT
eurjchem-2615	788	21	cc	cc	NOUN
eurjchem-2615	788	22	by	by	ADP
eurjchem-2615	788	23	nc	nc	PROPN
eurjchem-2615	788	24	)	)	PUNCT
eurjchem-2615	788	25	(	(	PUNCT
eurjchem-2615	788	26	international	international	ADJ
eurjchem-2615	788	27	,	,	PUNCT
eurjchem-2615	788	28	v4.0	v4.0	NOUN
eurjchem-2615	788	29	)	)	PUNCT
eurjchem-2615	788	30	license	license	NOUN
eurjchem-2615	788	31	(	(	PUNCT
eurjchem-2615	788	32	http://creativecommons.org/licenses/by-nc/4.0	http://creativecommons.org/licenses/by-nc/4.0	NOUN
eurjchem-2615	788	33	)	)	PUNCT
eurjchem-2615	788	34	.	.	PUNCT
eurjchem-2615	789	1	by	by	ADP
eurjchem-2615	789	2	accessing	access	VERB
eurjchem-2615	789	3	the	the	DET
eurjchem-2615	789	4	work	work	NOUN
eurjchem-2615	789	5	,	,	PUNCT
eurjchem-2615	789	6	you	you	PRON
eurjchem-2615	789	7	hereby	hereby	ADV
eurjchem-2615	789	8	accept	accept	VERB
eurjchem-2615	789	9	the	the	DET
eurjchem-2615	789	10	terms	term	NOUN
eurjchem-2615	789	11	.	.	PUNCT
eurjchem-2615	790	1	this	this	PRON
eurjchem-2615	790	2	is	be	AUX
eurjchem-2615	790	3	an	an	DET
eurjchem-2615	790	4	open	open	ADJ
eurjchem-2615	790	5	access	access	NOUN
eurjchem-2615	790	6	article	article	NOUN
eurjchem-2615	790	7	distributed	distribute	VERB
eurjchem-2615	790	8	under	under	ADP
eurjchem-2615	790	9	the	the	DET
eurjchem-2615	790	10	terms	term	NOUN
eurjchem-2615	790	11	and	and	CCONJ
eurjchem-2615	790	12	conditions	condition	NOUN
eurjchem-2615	790	13	of	of	ADP
eurjchem-2615	790	14	the	the	DET
eurjchem-2615	790	15	cc	cc	PROPN
eurjchem-2615	790	16	by	by	ADP
eurjchem-2615	790	17	nc	nc	PROPN
eurjchem-2615	790	18	license	license	PROPN
eurjchem-2615	790	19	,	,	PUNCT
eurjchem-2615	790	20	which	which	PRON
eurjchem-2615	790	21	permits	permit	VERB
eurjchem-2615	790	22	unrestricted	unrestricted	ADJ
eurjchem-2615	790	23	non	non	ADJ
eurjchem-2615	790	24	-	-	ADJ
eurjchem-2615	790	25	commercial	commercial	ADJ
eurjchem-2615	790	26	use	use	NOUN
eurjchem-2615	790	27	,	,	PUNCT
eurjchem-2615	790	28	distribution	distribution	NOUN
eurjchem-2615	790	29	,	,	PUNCT
eurjchem-2615	790	30	and	and	CCONJ
eurjchem-2615	790	31	reproduction	reproduction	NOUN
eurjchem-2615	790	32	in	in	ADP
eurjchem-2615	790	33	any	any	DET
eurjchem-2615	790	34	medium	medium	NOUN
eurjchem-2615	790	35	,	,	PUNCT
eurjchem-2615	790	36	provided	provide	VERB
eurjchem-2615	790	37	the	the	DET
eurjchem-2615	790	38	original	original	ADJ
eurjchem-2615	790	39	work	work	NOUN
eurjchem-2615	790	40	is	be	AUX
eurjchem-2615	790	41	properly	properly	ADV
eurjchem-2615	790	42	cited	cite	VERB
eurjchem-2615	790	43	without	without	ADP
eurjchem-2615	790	44	any	any	DET
eurjchem-2615	790	45	further	further	ADJ
eurjchem-2615	790	46	permission	permission	NOUN
eurjchem-2615	790	47	from	from	ADP
eurjchem-2615	790	48	atlanta	atlanta	PROPN
eurjchem-2615	790	49	publishing	publishing	PROPN
eurjchem-2615	790	50	house	house	PROPN
eurjchem-2615	790	51	llc	llc	PROPN
eurjchem-2615	790	52	(	(	PUNCT
eurjchem-2615	790	53	european	european	PROPN
eurjchem-2615	790	54	journal	journal	PROPN
eurjchem-2615	790	55	of	of	ADP
eurjchem-2615	790	56	chemistry	chemistry	NOUN
eurjchem-2615	790	57	)	)	PUNCT
eurjchem-2615	790	58	.	.	PUNCT
eurjchem-2615	791	1	no	no	DET
eurjchem-2615	791	2	use	use	NOUN
eurjchem-2615	791	3	,	,	PUNCT
eurjchem-2615	791	4	distribution	distribution	NOUN
eurjchem-2615	791	5	,	,	PUNCT
eurjchem-2615	791	6	or	or	CCONJ
eurjchem-2615	791	7	reproduction	reproduction	NOUN
eurjchem-2615	791	8	is	be	AUX
eurjchem-2615	791	9	permitted	permit	VERB
eurjchem-2615	791	10	which	which	PRON
eurjchem-2615	791	11	does	do	AUX
eurjchem-2615	791	12	not	not	PART
eurjchem-2615	791	13	comply	comply	VERB
eurjchem-2615	791	14	with	with	ADP
eurjchem-2615	791	15	these	these	DET
eurjchem-2615	791	16	terms	term	NOUN
eurjchem-2615	791	17	.	.	PUNCT
eurjchem-2615	792	1	permissions	permission	NOUN
eurjchem-2615	792	2	for	for	ADP
eurjchem-2615	792	3	commercial	commercial	ADJ
eurjchem-2615	792	4	use	use	NOUN
eurjchem-2615	792	5	of	of	ADP
eurjchem-2615	792	6	this	this	DET
eurjchem-2615	792	7	work	work	NOUN
eurjchem-2615	792	8	beyond	beyond	ADP
eurjchem-2615	792	9	the	the	DET
eurjchem-2615	792	10	scope	scope	NOUN
eurjchem-2615	792	11	of	of	ADP
eurjchem-2615	792	12	the	the	DET
eurjchem-2615	792	13	license	license	NOUN
eurjchem-2615	792	14	(	(	PUNCT
eurjchem-2615	792	15	https://www.eurjchem.com/index.php/eurjchem/terms	https://www.eurjchem.com/index.php/eurjchem/term	NOUN
eurjchem-2615	792	16	)	)	PUNCT
eurjchem-2615	792	17	are	be	AUX
eurjchem-2615	792	18	administered	administer	VERB
eurjchem-2615	792	19	by	by	ADP
eurjchem-2615	792	20	atlanta	atlanta	PROPN
eurjchem-2615	792	21	publishing	publishing	PROPN
eurjchem-2615	792	22	house	house	PROPN
eurjchem-2615	792	23	llc	llc	PROPN
eurjchem-2615	792	24	(	(	PUNCT
eurjchem-2615	792	25	european	european	PROPN
eurjchem-2615	792	26	journal	journal	PROPN
eurjchem-2615	792	27	of	of	ADP
eurjchem-2615	792	28	chemistry	chemistry	NOUN
eurjchem-2615	792	29	)	)	PUNCT
eurjchem-2615	792	30	.	.	PUNCT
eurjchem-2615	793	1	https://doi.org/10.1002/ardp.201900135	https://doi.org/10.1002/ardp.201900135	NOUN
eurjchem-2615	793	2	https://doi.org/10.1128/aac.01174%e2%80%9320	https://doi.org/10.1128/aac.01174%e2%80%9320	X
eurjchem-2615	793	3	https://www.eurjchem.com/index.php/eurjchem/terms	https://www.eurjchem.com/index.php/eurjchem/term	VERB
eurjchem-2615	793	4	http://creativecommons.org/licenses/by-nc/4.0	http://creativecommons.org/licenses/by-nc/4.0	PROPN
eurjchem-2615	793	5	https://www.eurjchem.com/index.php/eurjchem/terms	https://www.eurjchem.com/index.php/eurjchem/term	NOUN
eurjchem-2615	793	6	1	1	NUM
eurjchem-2615	793	7	.	.	PUNCT
eurjchem-2615	794	1	introduction	introduction	NOUN
eurjchem-2615	794	2	2	2	NUM
eurjchem-2615	794	3	.	.	PUNCT
eurjchem-2615	794	4	fundamentals	fundamental	NOUN
eurjchem-2615	794	5	of	of	ADP
eurjchem-2615	794	6	click	click	VERB
eurjchem-2615	794	7	chemistry	chemistry	NOUN
eurjchem-2615	794	8	in	in	ADP
eurjchem-2615	794	9	tb	tb	ADP
eurjchem-2615	794	10	research	research	NOUN
eurjchem-2615	794	11	2.1	2.1	NUM
eurjchem-2615	794	12	.	.	PUNCT
eurjchem-2615	795	1	conventional	conventional	ADJ
eurjchem-2615	795	2	tb	tb	X
eurjchem-2615	795	3	drug	drug	NOUN
eurjchem-2615	795	4	modification	modification	NOUN
eurjchem-2615	795	5	approaches	approach	NOUN
eurjchem-2615	795	6	face	face	VERB
eurjchem-2615	795	7	critical	critical	ADJ
eurjchem-2615	795	8	limitations	limitation	NOUN
eurjchem-2615	795	9	2.2	2.2	NUM
eurjchem-2615	795	10	.	.	PUNCT
eurjchem-2615	796	1	click	click	VERB
eurjchem-2615	796	2	chemistry	chemistry	NOUN
eurjchem-2615	796	3	’s	’s	PART
eurjchem-2615	796	4	unique	unique	ADJ
eurjchem-2615	796	5	synthetic	synthetic	ADJ
eurjchem-2615	796	6	advantages	advantage	NOUN
eurjchem-2615	796	7	in	in	ADP
eurjchem-2615	796	8	tb	tb	ADP
eurjchem-2615	796	9	drug	drug	NOUN
eurjchem-2615	796	10	development	development	NOUN
eurjchem-2615	796	11	2.2.1	2.2.1	NUM
eurjchem-2615	796	12	.	.	PUNCT
eurjchem-2615	797	1	mechanistic	mechanistic	ADJ
eurjchem-2615	797	2	insights	insight	NOUN
eurjchem-2615	797	3	into	into	AUX
eurjchem-2615	797	4	click	click	VERB
eurjchem-2615	797	5	chemistry	chemistry	NOUN
eurjchem-2615	797	6	2.2.2	2.2.2	NUM
eurjchem-2615	797	7	.	.	PUNCT
eurjchem-2615	798	1	click	click	VERB
eurjchem-2615	798	2	chemistry	chemistry	NOUN
eurjchem-2615	798	3	from	from	ADP
eurjchem-2615	798	4	structural	structural	ADJ
eurjchem-2615	798	5	modification	modification	NOUN
eurjchem-2615	798	6	to	to	ADP
eurjchem-2615	798	7	biological	biological	ADJ
eurjchem-2615	798	8	applications	application	NOUN
eurjchem-2615	798	9	3	3	NUM
eurjchem-2615	798	10	.	.	PUNCT
eurjchem-2615	798	11	triazole	triazole	NOUN
eurjchem-2615	798	12	heterocycle	heterocycle	NOUN
eurjchem-2615	798	13	as	as	ADP
eurjchem-2615	798	14	a	a	DET
eurjchem-2615	798	15	valuable	valuable	ADJ
eurjchem-2615	798	16	scaffold	scaffold	NOUN
eurjchem-2615	798	17	in	in	ADP
eurjchem-2615	798	18	drug	drug	NOUN
eurjchem-2615	798	19	discovery	discovery	NOUN
eurjchem-2615	798	20	4	4	NUM
eurjchem-2615	798	21	.	.	PUNCT
eurjchem-2615	799	1	1,2,3	1,2,3	NUM
eurjchem-2615	799	2	-	-	ADJ
eurjchem-2615	799	3	triazole	triazole	ADJ
eurjchem-2615	799	4	hybrids	hybrid	NOUN
eurjchem-2615	799	5	as	as	ADP
eurjchem-2615	799	6	potent	potent	ADJ
eurjchem-2615	799	7	anti	anti	ADJ
eurjchem-2615	799	8	-	-	ADJ
eurjchem-2615	799	9	tb	tb	ADJ
eurjchem-2615	799	10	agents	agent	NOUN
eurjchem-2615	799	11	4.1	4.1	NUM
eurjchem-2615	799	12	.	.	PUNCT
eurjchem-2615	800	1	azole-1,2,3	azole-1,2,3	ADJ
eurjchem-2615	800	2	-	-	PUNCT
eurjchem-2615	800	3	triazole	triazole	ADJ
eurjchem-2615	800	4	hybrids	hybrid	NOUN
eurjchem-2615	800	5	4.2	4.2	NUM
eurjchem-2615	800	6	.	.	PUNCT
eurjchem-2615	801	1	coumarin	coumarin	NOUN
eurjchem-2615	801	2	/	/	SYM
eurjchem-2615	801	3	chromene-1,2,3	chromene-1,2,3	NOUN
eurjchem-2615	801	4	-	-	PUNCT
eurjchem-2615	801	5	triazole	triazole	NOUN
eurjchem-2615	801	6	hybrids	hybrid	NOUN
eurjchem-2615	801	7	4.3	4.3	NUM
eurjchem-2615	801	8	.	.	PUNCT
eurjchem-2615	802	1	isoniazid-1,2,3	isoniazid-1,2,3	ADJ
eurjchem-2615	802	2	-	-	ADJ
eurjchem-2615	802	3	triazole	triazole	ADJ
eurjchem-2615	802	4	hybrids	hybrid	NOUN
eurjchem-2615	802	5	4.4	4.4	NUM
eurjchem-2615	802	6	.	.	PUNCT
eurjchem-2615	803	1	1,2,3	1,2,3	NUM
eurjchem-2615	803	2	-	-	ADJ
eurjchem-2615	803	3	triazole	triazole	ADJ
eurjchem-2615	803	4	-	-	PUNCT
eurjchem-2615	803	5	quinoline	quinoline	NOUN
eurjchem-2615	803	6	/	/	SYM
eurjchem-2615	803	7	dihydroquinoline	dihydroquinoline	NOUN
eurjchem-2615	803	8	hybrids	hybrid	NOUN
eurjchem-2615	803	9	4.5	4.5	NUM
eurjchem-2615	803	10	.	.	PUNCT
eurjchem-2615	804	1	1,2,3	1,2,3	NUM
eurjchem-2615	804	2	-	-	ADJ
eurjchem-2615	804	3	triazole	triazole	ADJ
eurjchem-2615	804	4	-	-	PUNCT
eurjchem-2615	804	5	quinolone	quinolone	NOUN
eurjchem-2615	804	6	hybrids	hybrid	NOUN
eurjchem-2615	804	7	4.6	4.6	NUM
eurjchem-2615	804	8	.	.	PUNCT
eurjchem-2615	805	1	1,2,3	1,2,3	NUM
eurjchem-2615	805	2	-	-	ADJ
eurjchem-2615	805	3	triazole	triazole	ADJ
eurjchem-2615	805	4	-	-	PUNCT
eurjchem-2615	805	5	ferrocene	ferrocene	NOUN
eurjchem-2615	805	6	hybrids	hybrid	NOUN
eurjchem-2615	805	7	4.7	4.7	NUM
eurjchem-2615	805	8	.	.	PUNCT
eurjchem-2615	806	1	1,2,3	1,2,3	NUM
eurjchem-2615	806	2	-	-	ADJ
eurjchem-2615	806	3	triazole	triazole	NOUN
eurjchem-2615	806	4	-	-	PUNCT
eurjchem-2615	806	5	isatin	isatin	NOUN
eurjchem-2615	806	6	hybrids	hybrid	NOUN
eurjchem-2615	806	7	4.8	4.8	NUM
eurjchem-2615	806	8	.	.	PUNCT
eurjchem-2615	807	1	1,2,3	1,2,3	NUM
eurjchem-2615	807	2	-	-	ADJ
eurjchem-2615	807	3	triazole	triazole	ADJ
eurjchem-2615	807	4	-	-	PUNCT
eurjchem-2615	807	5	furan	furan	NOUN
eurjchem-2615	807	6	hybrids	hybrid	NOUN
eurjchem-2615	807	7	4.9	4.9	NUM
eurjchem-2615	807	8	.	.	PUNCT
eurjchem-2615	808	1	miscellaneous	miscellaneous	ADJ
eurjchem-2615	808	2	1,2,3	1,2,3	NUM
eurjchem-2615	808	3	-	-	PUNCT
eurjchem-2615	808	4	triazoles	triazole	NOUN
eurjchem-2615	808	5	5	5	NUM
eurjchem-2615	808	6	.	.	PUNCT
eurjchem-2615	808	7	conclusions	conclusion	NOUN
eurjchem-2615	808	8	acknowledgements	acknowledgement	VERB
eurjchem-2615	808	9	disclosure	disclosure	NOUN
eurjchem-2615	808	10	statement	statement	NOUN
eurjchem-2615	808	11	funding	fund	VERB
eurjchem-2615	808	12	credit	credit	NOUN
eurjchem-2615	808	13	authorship	authorship	NOUN
eurjchem-2615	808	14	contribution	contribution	NOUN
eurjchem-2615	808	15	statement	statement	NOUN
eurjchem-2615	808	16	orcid	orcid	NOUN
eurjchem-2615	808	17	and	and	CCONJ
eurjchem-2615	808	18	email	email	NOUN
eurjchem-2615	808	19	references	reference	NOUN
eurjchem-2615	808	20	printfield10	printfield10	PROPN
eurjchem-2615	808	21	:	:	PUNCT
eurjchem-2615	808	22	printfield11	printfield11	NOUN
eurjchem-2615	808	23	:	:	PUNCT
eurjchem-2615	808	24	printfield12	printfield12	PROPN
eurjchem-2615	808	25	:	:	PUNCT
eurjchem-2615	808	26	printfield13	printfield13	VERB
eurjchem-2615	808	27	:	:	PUNCT
eurjchem-2615	808	28	printfield14	printfield14	NOUN
eurjchem-2615	808	29	:	:	PUNCT
eurjchem-2615	808	30	printfield15	printfield15	NOUN
eurjchem-2615	808	31	:	:	PUNCT
eurjchem-2615	808	32	printfield16	printfield16	ADJ
eurjchem-2615	808	33	:	:	PUNCT
eurjchem-2615	808	34	printfield17	printfield17	NOUN
eurjchem-2615	808	35	:	:	PUNCT
eurjchem-2615	808	36	printfield18	printfield18	NOUN
eurjchem-2615	808	37	:	:	PUNCT
eurjchem-2615	808	38	printfield19	printfield19	NOUN
eurjchem-2615	808	39	:	:	PUNCT
eurjchem-2615	808	40	printfield110	printfield110	PROPN
eurjchem-2615	808	41	:	:	PUNCT
eurjchem-2615	808	42	printfield111	printfield111	PROPN
eurjchem-2615	808	43	:	:	PUNCT
eurjchem-2615	808	44	printfield112	printfield112	PROPN
eurjchem-2615	808	45	:	:	PUNCT
eurjchem-2615	808	46	printfield113	printfield113	ADJ
eurjchem-2615	808	47	:	:	PUNCT
eurjchem-2615	808	48	printfield20	printfield20	PROPN
eurjchem-2615	808	49	:	:	PUNCT
eurjchem-2615	808	50	printfield21	printfield21	ADJ
eurjchem-2615	808	51	:	:	PUNCT
eurjchem-2615	808	52	printfield22	printfield22	NOUN
eurjchem-2615	808	53	:	:	PUNCT
eurjchem-2615	808	54	printfield23	printfield23	NOUN
eurjchem-2615	808	55	:	:	PUNCT
eurjchem-2615	808	56	printfield24	printfield24	NOUN
eurjchem-2615	808	57	:	:	PUNCT
eurjchem-2615	808	58	printfield25	printfield25	NOUN
eurjchem-2615	808	59	:	:	PUNCT
eurjchem-2615	808	60	printfield26	printfield26	ADJ
eurjchem-2615	808	61	:	:	PUNCT
eurjchem-2615	808	62	printfield27	printfield27	NOUN
eurjchem-2615	808	63	:	:	PUNCT
eurjchem-2615	808	64	printfield28	printfield28	NOUN
eurjchem-2615	808	65	:	:	PUNCT
eurjchem-2615	808	66	printfield29	printfield29	ADV
eurjchem-2615	808	67	:	:	PUNCT
eurjchem-2615	808	68	printfield210	printfield210	PROPN
eurjchem-2615	808	69	:	:	PUNCT
eurjchem-2615	808	70	printfield211	printfield211	PROPN
eurjchem-2615	808	71	:	:	PUNCT
eurjchem-2615	808	72	printfield212	printfield212	PROPN
eurjchem-2615	808	73	:	:	PUNCT
eurjchem-2615	808	74	printfield213	printfield213	PROPN
eurjchem-2615	808	75	:	:	PUNCT