id	sid	tid	token	lemma	pos
eurjchem-371	1	1	untitled	untitle	VERB
eurjchem-371	1	2	european	european	PROPN
eurjchem-371	1	3	journal	journal	PROPN
eurjchem-371	1	4	of	of	ADP
eurjchem-371	1	5	chemistry	chemistry	NOUN
eurjchem-371	1	6	2	2	NUM
eurjchem-371	1	7	(	(	PUNCT
eurjchem-371	1	8	1	1	NUM
eurjchem-371	1	9	)	)	PUNCT
eurjchem-371	1	10	(	(	PUNCT
eurjchem-371	1	11	2011	2011	NUM
eurjchem-371	1	12	)	)	PUNCT
eurjchem-371	1	13	36‐46	36‐46	NUM
eurjchem-371	1	14	european	european	PROPN
eurjchem-371	1	15	journal	journal	PROPN
eurjchem-371	1	16	of	of	ADP
eurjchem-371	1	17	chemistry	chemistry	NOUN
eurjchem-371	1	18	issn	issn	PROPN
eurjchem-371	1	19	2153‐2249	2153‐2249	PROPN
eurjchem-371	1	20	(	(	PUNCT
eurjchem-371	1	21	print	print	NOUN
eurjchem-371	1	22	)	)	PUNCT
eurjchem-371	1	23	/	/	SYM
eurjchem-371	1	24	issn	issn	PROPN
eurjchem-371	1	25	2153‐2257	2153‐2257	NUM
eurjchem-371	1	26	(	(	PUNCT
eurjchem-371	1	27	online	online	ADJ
eurjchem-371	1	28	)	)	PUNCT
eurjchem-371	1	29			NOUN
eurjchem-371	1	30	2011	2011	NUM
eurjchem-371	1	31	eurjchem	eurjchem	PROPN
eurjchem-371	1	32	doi:10.5155	doi:10.5155	PROPN
eurjchem-371	1	33	/	/	SYM
eurjchem-371	1	34	eurjchem.2.1.36‐46.371	eurjchem.2.1.36‐46.371	PROPN
eurjchem-371	1	35	european	european	ADJ
eurjchem-371	1	36	journal	journal	PROPN
eurjchem-371	1	37	of	of	ADP
eurjchem-371	1	38	chemistry	chemistry	PROPN
eurjchem-371	1	39	journal	journal	PROPN
eurjchem-371	1	40	homepage	homepage	NOUN
eurjchem-371	1	41	:	:	PUNCT
eurjchem-371	1	42	www.eurjchem.com	www.eurjchem.com	X
eurjchem-371	1	43	physico‐chemical	physico‐chemical	ADJ
eurjchem-371	1	44	characterization	characterization	NOUN
eurjchem-371	1	45	of	of	ADP
eurjchem-371	1	46	some	some	DET
eurjchem-371	1	47	beta	beta	ADJ
eurjchem-371	1	48	blockers	blocker	NOUN
eurjchem-371	1	49	and	and	CCONJ
eurjchem-371	1	50	anti‐diabetic	anti‐diabetic	ADJ
eurjchem-371	1	51	drugs	drug	NOUN
eurjchem-371	1	52	‐	‐	ADV
eurjchem-371	1	53	potentiometric	potentiometric	ADJ
eurjchem-371	1	54	and	and	CCONJ
eurjchem-371	1	55	spectrophotometric	spectrophotometric	ADJ
eurjchem-371	1	56	pka	pka	PROPN
eurjchem-371	1	57	determination	determination	NOUN
eurjchem-371	1	58	in	in	ADP
eurjchem-371	1	59	different	different	ADJ
eurjchem-371	1	60	co‐solvents	co‐solvent	NOUN
eurjchem-371	1	61	lakshmi	lakshmi	NOUN
eurjchem-371	1	62	narasimham	narasimham	VERB
eurjchem-371	1	63	*	*	PUNCT
eurjchem-371	1	64	and	and	CCONJ
eurjchem-371	1	65	vasant	vasant	PROPN
eurjchem-371	1	66	dnyandeo	dnyandeo	PROPN
eurjchem-371	1	67	barhate	barhate	PROPN
eurjchem-371	1	68	department	department	NOUN
eurjchem-371	1	69	of	of	ADP
eurjchem-371	1	70	chemistry	chemistry	NOUN
eurjchem-371	1	71	,	,	PUNCT
eurjchem-371	1	72	vivekanand	vivekanand	NOUN
eurjchem-371	1	73	education	education	PROPN
eurjchem-371	1	74	society	society	NOUN
eurjchem-371	1	75	’s	’s	PART
eurjchem-371	1	76	college	college	PROPN
eurjchem-371	1	77	of	of	ADP
eurjchem-371	1	78	arts	art	NOUN
eurjchem-371	1	79	,	,	PUNCT
eurjchem-371	1	80	science	science	NOUN
eurjchem-371	1	81	and	and	CCONJ
eurjchem-371	1	82	commerce	commerce	PROPN
eurjchem-371	1	83	,	,	PUNCT
eurjchem-371	1	84	chembur	chembur	PROPN
eurjchem-371	1	85	,	,	PUNCT
eurjchem-371	1	86	mumbai	mumbai	PROPN
eurjchem-371	1	87	,	,	PUNCT
eurjchem-371	1	88	in‐400071	in‐400071	PROPN
eurjchem-371	1	89	,	,	PUNCT
eurjchem-371	1	90	india	india	PROPN
eurjchem-371	1	91	*	*	PUNCT
eurjchem-371	1	92	corresponding	correspond	VERB
eurjchem-371	1	93	author	author	NOUN
eurjchem-371	1	94	at	at	ADP
eurjchem-371	1	95	:	:	PUNCT
eurjchem-371	1	96	department	department	NOUN
eurjchem-371	1	97	of	of	ADP
eurjchem-371	1	98	chemistry	chemistry	NOUN
eurjchem-371	1	99	,	,	PUNCT
eurjchem-371	1	100	vivekanand	vivekanand	NOUN
eurjchem-371	1	101	education	education	PROPN
eurjchem-371	1	102	society	society	NOUN
eurjchem-371	1	103	’s	’s	PART
eurjchem-371	1	104	college	college	PROPN
eurjchem-371	1	105	of	of	ADP
eurjchem-371	1	106	arts	art	NOUN
eurjchem-371	1	107	,	,	PUNCT
eurjchem-371	1	108	science	science	NOUN
eurjchem-371	1	109	and	and	CCONJ
eurjchem-371	1	110	commerce	commerce	PROPN
eurjchem-371	1	111	,	,	PUNCT
eurjchem-371	1	112	chembur	chembur	PROPN
eurjchem-371	1	113	,	,	PUNCT
eurjchem-371	1	114	mumbai	mumbai	PROPN
eurjchem-371	1	115	,	,	PUNCT
eurjchem-371	1	116	in‐400071	in‐400071	PROPN
eurjchem-371	1	117	,	,	PUNCT
eurjchem-371	1	118	india	india	PROPN
eurjchem-371	1	119	.	.	PUNCT
eurjchem-371	2	1	tel	tel	PROPN
eurjchem-371	2	2	.	.	PUNCT
eurjchem-371	2	3	:	:	PUNCT
eurjchem-371	3	1	+91.9765800468	+91.9765800468	ADP
eurjchem-371	3	2	;	;	PUNCT
eurjchem-371	3	3	fax	fax	NOUN
eurjchem-371	3	4	:	:	PUNCT
eurjchem-371	3	5	+91.9823240411	+91.9823240411	PROPN
eurjchem-371	3	6	.	.	PUNCT
eurjchem-371	3	7	e‐mail	e‐mail	PUNCT
eurjchem-371	4	1	address	address	NOUN
eurjchem-371	4	2	:	:	PUNCT
eurjchem-371	4	3	lakshmi_n9@hotmail.com	lakshmi_n9@hotmail.com	X
eurjchem-371	4	4	(	(	PUNCT
eurjchem-371	4	5	l.	l.	PROPN
eurjchem-371	4	6	narasimham	narasimham	PROPN
eurjchem-371	4	7	)	)	PUNCT
eurjchem-371	4	8	.	.	PUNCT
eurjchem-371	5	1	article	article	NOUN
eurjchem-371	5	2	information	information	PROPN
eurjchem-371	5	3	abstract	abstract	ADV
eurjchem-371	5	4	received	receive	VERB
eurjchem-371	5	5	:	:	PUNCT
eurjchem-371	5	6	14	14	NUM
eurjchem-371	5	7	december	december	PROPN
eurjchem-371	5	8	2010	2010	NUM
eurjchem-371	5	9	received	receive	VERB
eurjchem-371	5	10	in	in	ADP
eurjchem-371	5	11	revised	revise	VERB
eurjchem-371	5	12	form	form	NOUN
eurjchem-371	5	13	:	:	PUNCT
eurjchem-371	5	14	21	21	NUM
eurjchem-371	5	15	january	january	NOUN
eurjchem-371	5	16	2011	2011	NUM
eurjchem-371	5	17	accepted	accept	VERB
eurjchem-371	5	18	:	:	PUNCT
eurjchem-371	5	19	21	21	NUM
eurjchem-371	5	20	january	january	PROPN
eurjchem-371	5	21	2011	2011	NUM
eurjchem-371	5	22	online	online	ADV
eurjchem-371	5	23	:	:	PUNCT
eurjchem-371	5	24	31	31	NUM
eurjchem-371	5	25	march	march	NOUN
eurjchem-371	5	26	2011	2011	NUM
eurjchem-371	5	27	keywords	keyword	NOUN
eurjchem-371	5	28	in	in	ADP
eurjchem-371	5	29	the	the	DET
eurjchem-371	5	30	present	present	ADJ
eurjchem-371	5	31	study	study	NOUN
eurjchem-371	5	32	we	we	PRON
eurjchem-371	5	33	have	have	AUX
eurjchem-371	5	34	determined	determine	VERB
eurjchem-371	5	35	the	the	DET
eurjchem-371	5	36	fundamental	fundamental	ADJ
eurjchem-371	5	37	physico‐chemical	physico‐chemical	ADJ
eurjchem-371	5	38	properties	property	NOUN
eurjchem-371	5	39	such	such	ADJ
eurjchem-371	5	40	as	as	ADP
eurjchem-371	5	41	,	,	PUNCT
eurjchem-371	5	42	ionization	ionization	NOUN
eurjchem-371	5	43	constant	constant	ADJ
eurjchem-371	5	44	(	(	PUNCT
eurjchem-371	5	45	pka	pka	NOUN
eurjchem-371	5	46	)	)	PUNCT
eurjchem-371	5	47	and	and	CCONJ
eurjchem-371	5	48	lipophilicity	lipophilicity	NOUN
eurjchem-371	5	49	(	(	PUNCT
eurjchem-371	5	50	log	log	VERB
eurjchem-371	5	51	p	p	NOUN
eurjchem-371	5	52	)	)	PUNCT
eurjchem-371	5	53	of	of	ADP
eurjchem-371	5	54	some	some	DET
eurjchem-371	5	55	‐blockers	‐blocker	NOUN
eurjchem-371	5	56	and	and	CCONJ
eurjchem-371	5	57	anti‐diabetic	anti‐diabetic	ADJ
eurjchem-371	5	58	drugs	drug	NOUN
eurjchem-371	5	59	.	.	PUNCT
eurjchem-371	6	1	the	the	DET
eurjchem-371	6	2	apparent	apparent	ADJ
eurjchem-371	6	3	ionization	ionization	NOUN
eurjchem-371	6	4	constant	constant	ADJ
eurjchem-371	6	5	(	(	PUNCT
eurjchem-371	6	6	pska	pska	NOUN
eurjchem-371	6	7	)	)	PUNCT
eurjchem-371	6	8	of	of	ADP
eurjchem-371	6	9	selected	select	VERB
eurjchem-371	6	10	drugs	drug	NOUN
eurjchem-371	6	11	were	be	AUX
eurjchem-371	6	12	determined	determine	VERB
eurjchem-371	6	13	using	use	VERB
eurjchem-371	6	14	potentiometric	potentiometric	ADJ
eurjchem-371	6	15	titration	titration	NOUN
eurjchem-371	6	16	in	in	ADP
eurjchem-371	6	17	various	various	ADJ
eurjchem-371	6	18	co	co	X
eurjchem-371	6	19	solvent‐water	solvent‐water	PROPN
eurjchem-371	6	20	mixtures	mixture	NOUN
eurjchem-371	6	21	(	(	PUNCT
eurjchem-371	6	22	methanol	methanol	NOUN
eurjchem-371	6	23	,	,	PUNCT
eurjchem-371	6	24	ethanol	ethanol	NOUN
eurjchem-371	6	25	,	,	PUNCT
eurjchem-371	6	26	acetonitrile	acetonitrile	NOUN
eurjchem-371	6	27	and	and	CCONJ
eurjchem-371	6	28	dioxane	dioxane	NOUN
eurjchem-371	6	29	)	)	PUNCT
eurjchem-371	6	30	at	at	ADP
eurjchem-371	6	31	different	different	ADJ
eurjchem-371	6	32	temperatures	temperature	NOUN
eurjchem-371	6	33	(	(	PUNCT
eurjchem-371	6	34	25	25	NUM
eurjchem-371	6	35	to	to	PART
eurjchem-371	6	36	45	45	NUM
eurjchem-371	6	37	°	°	NOUN
eurjchem-371	6	38	c	c	NOUN
eurjchem-371	6	39	)	)	PUNCT
eurjchem-371	6	40	and	and	CCONJ
eurjchem-371	6	41	ionic	ionic	ADJ
eurjchem-371	6	42	strengths	strength	NOUN
eurjchem-371	6	43	(	(	PUNCT
eurjchem-371	6	44	0.15	0.15	NUM
eurjchem-371	6	45	to	to	PART
eurjchem-371	6	46	0.5	0.5	NUM
eurjchem-371	6	47	m	m	NOUN
eurjchem-371	6	48	)	)	PUNCT
eurjchem-371	6	49	.	.	PUNCT
eurjchem-371	7	1	effect	effect	NOUN
eurjchem-371	7	2	of	of	ADP
eurjchem-371	7	3	temperature	temperature	NOUN
eurjchem-371	7	4	,	,	PUNCT
eurjchem-371	7	5	ionic	ionic	ADJ
eurjchem-371	7	6	strength	strength	NOUN
eurjchem-371	7	7	and	and	CCONJ
eurjchem-371	7	8	dielectric	dielectric	ADJ
eurjchem-371	7	9	constant	constant	ADJ
eurjchem-371	7	10	on	on	ADP
eurjchem-371	7	11	dissociation	dissociation	NOUN
eurjchem-371	7	12	constant	constant	ADJ
eurjchem-371	7	13	has	have	AUX
eurjchem-371	7	14	been	be	AUX
eurjchem-371	7	15	compared	compare	VERB
eurjchem-371	7	16	.	.	PUNCT
eurjchem-371	8	1	the	the	DET
eurjchem-371	8	2	aqueous	aqueous	ADJ
eurjchem-371	8	3	pka	pka	PROPN
eurjchem-371	8	4	values	value	NOUN
eurjchem-371	8	5	were	be	AUX
eurjchem-371	8	6	then	then	ADV
eurjchem-371	8	7	obtained	obtain	VERB
eurjchem-371	8	8	by	by	ADP
eurjchem-371	8	9	yasuda‐shedlovsky	yasuda‐shedlovsky	ADJ
eurjchem-371	8	10	extrapolation	extrapolation	NOUN
eurjchem-371	8	11	.	.	PUNCT
eurjchem-371	9	1	in	in	ADP
eurjchem-371	9	2	the	the	DET
eurjchem-371	9	3	case	case	NOUN
eurjchem-371	9	4	of	of	ADP
eurjchem-371	9	5	water‐soluble	water‐soluble	ADJ
eurjchem-371	9	6	drugs	drug	NOUN
eurjchem-371	9	7	(	(	PUNCT
eurjchem-371	9	8	amiloride	amiloride	ADJ
eurjchem-371	9	9	hydrochloride	hydrochloride	NOUN
eurjchem-371	9	10	,	,	PUNCT
eurjchem-371	9	11	metoprolol	metoprolol	NOUN
eurjchem-371	9	12	tartrate	tartrate	NOUN
eurjchem-371	9	13	and	and	CCONJ
eurjchem-371	9	14	propranolol	propranolol	NOUN
eurjchem-371	9	15	hydrochloride	hydrochloride	NOUN
eurjchem-371	9	16	)	)	PUNCT
eurjchem-371	9	17	,	,	PUNCT
eurjchem-371	9	18	the	the	DET
eurjchem-371	9	19	extrapolated	extrapolate	VERB
eurjchem-371	9	20	results	result	NOUN
eurjchem-371	9	21	were	be	AUX
eurjchem-371	9	22	in	in	ADP
eurjchem-371	9	23	good	good	ADJ
eurjchem-371	9	24	agreement	agreement	NOUN
eurjchem-371	9	25	with	with	ADP
eurjchem-371	9	26	that	that	PRON
eurjchem-371	9	27	of	of	ADP
eurjchem-371	9	28	pka	pka	PROPN
eurjchem-371	9	29	values	value	NOUN
eurjchem-371	9	30	measured	measure	VERB
eurjchem-371	9	31	in	in	ADP
eurjchem-371	9	32	aqueous	aqueous	ADJ
eurjchem-371	9	33	solutions	solution	NOUN
eurjchem-371	9	34	under	under	ADP
eurjchem-371	9	35	the	the	DET
eurjchem-371	9	36	same	same	ADJ
eurjchem-371	9	37	experimental	experimental	ADJ
eurjchem-371	9	38	conditions	condition	NOUN
eurjchem-371	9	39	,	,	PUNCT
eurjchem-371	9	40	while	while	SCONJ
eurjchem-371	9	41	for	for	ADP
eurjchem-371	9	42	the	the	DET
eurjchem-371	9	43	water	water	NOUN
eurjchem-371	9	44	insoluble	insoluble	ADJ
eurjchem-371	9	45	drugs	drug	NOUN
eurjchem-371	9	46	(	(	PUNCT
eurjchem-371	9	47	atenolol	atenolol	PROPN
eurjchem-371	9	48	,	,	PUNCT
eurjchem-371	9	49	amlodipine	amlodipine	NOUN
eurjchem-371	9	50	besylate	besylate	NOUN
eurjchem-371	9	51	,	,	PUNCT
eurjchem-371	9	52	gliclazide	gliclazide	NOUN
eurjchem-371	9	53	,	,	PUNCT
eurjchem-371	9	54	glipizide	glipizide	ADJ
eurjchem-371	9	55	,	,	PUNCT
eurjchem-371	9	56	glibenclamide	glibenclamide	NOUN
eurjchem-371	9	57	and	and	CCONJ
eurjchem-371	9	58	pioglitazone	pioglitazone	NOUN
eurjchem-371	9	59	)	)	PUNCT
eurjchem-371	9	60	,	,	PUNCT
eurjchem-371	9	61	the	the	DET
eurjchem-371	9	62	extrapolated	extrapolate	VERB
eurjchem-371	9	63	results	result	NOUN
eurjchem-371	9	64	were	be	AUX
eurjchem-371	9	65	in	in	ADP
eurjchem-371	9	66	good	good	ADJ
eurjchem-371	9	67	agreement	agreement	NOUN
eurjchem-371	9	68	with	with	ADP
eurjchem-371	9	69	the	the	DET
eurjchem-371	9	70	literature	literature	NOUN
eurjchem-371	9	71	values	value	NOUN
eurjchem-371	9	72	.	.	PUNCT
eurjchem-371	10	1	for	for	ADP
eurjchem-371	10	2	few	few	ADJ
eurjchem-371	10	3	of	of	ADP
eurjchem-371	10	4	the	the	DET
eurjchem-371	10	5	selected	select	VERB
eurjchem-371	10	6	drugs	drug	NOUN
eurjchem-371	10	7	,	,	PUNCT
eurjchem-371	10	8	the	the	DET
eurjchem-371	10	9	pska	pska	NOUN
eurjchem-371	10	10	was	be	AUX
eurjchem-371	10	11	determined	determine	VERB
eurjchem-371	10	12	spectrophotometrically	spectrophotometrically	ADV
eurjchem-371	10	13	and	and	CCONJ
eurjchem-371	10	14	the	the	DET
eurjchem-371	10	15	results	result	NOUN
eurjchem-371	10	16	were	be	AUX
eurjchem-371	10	17	compared	compare	VERB
eurjchem-371	10	18	with	with	ADP
eurjchem-371	10	19	that	that	PRON
eurjchem-371	10	20	of	of	ADP
eurjchem-371	10	21	potentiometry	potentiometry	NOUN
eurjchem-371	10	22	in	in	ADP
eurjchem-371	10	23	various	various	ADJ
eurjchem-371	10	24	co	co	ADJ
eurjchem-371	10	25	solvent	solvent	ADJ
eurjchem-371	10	26	mixtures	mixture	NOUN
eurjchem-371	10	27	.	.	PUNCT
eurjchem-371	11	1	the	the	DET
eurjchem-371	11	2	measured	measure	VERB
eurjchem-371	11	3	log	log	NOUN
eurjchem-371	11	4	p	p	NOUN
eurjchem-371	11	5	values	value	NOUN
eurjchem-371	11	6	of	of	ADP
eurjchem-371	11	7	selected	select	VERB
eurjchem-371	11	8	drugs	drug	NOUN
eurjchem-371	11	9	showed	show	VERB
eurjchem-371	11	10	acceptable	acceptable	ADJ
eurjchem-371	11	11	range	range	NOUN
eurjchem-371	11	12	to	to	ADP
eurjchem-371	11	13	that	that	PRON
eurjchem-371	11	14	of	of	ADP
eurjchem-371	11	15	literature	literature	NOUN
eurjchem-371	11	16	values	value	NOUN
eurjchem-371	11	17	.	.	PUNCT
eurjchem-371	12	1	pka	pka	PROPN
eurjchem-371	12	2	potentiometry	potentiometry	NOUN
eurjchem-371	12	3	co‐solvents	co‐solvent	NOUN
eurjchem-371	12	4	lipophilicity	lipophilicity	VERB
eurjchem-371	12	5	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	12	6	hplc	hplc	NOUN
eurjchem-371	12	7	1	1	NUM
eurjchem-371	12	8	.	.	PUNCT
eurjchem-371	13	1	introduction	introduction	NOUN
eurjchem-371	13	2	there	there	PRON
eurjchem-371	13	3	are	be	VERB
eurjchem-371	13	4	different	different	ADJ
eurjchem-371	13	5	methods	method	NOUN
eurjchem-371	13	6	by	by	ADP
eurjchem-371	13	7	which	which	PRON
eurjchem-371	13	8	dissociation	dissociation	NOUN
eurjchem-371	13	9	constant	constant	ADJ
eurjchem-371	13	10	of	of	ADP
eurjchem-371	13	11	weak	weak	ADJ
eurjchem-371	13	12	acids	acid	NOUN
eurjchem-371	13	13	and	and	CCONJ
eurjchem-371	13	14	bases	basis	NOUN
eurjchem-371	13	15	can	can	AUX
eurjchem-371	13	16	be	be	AUX
eurjchem-371	13	17	determined	determine	VERB
eurjchem-371	13	18	.	.	PUNCT
eurjchem-371	14	1	the	the	DET
eurjchem-371	14	2	potentiometric	potentiometric	ADJ
eurjchem-371	14	3	methods	method	NOUN
eurjchem-371	14	4	are	be	AUX
eurjchem-371	14	5	widely	widely	ADV
eurjchem-371	14	6	used	use	VERB
eurjchem-371	14	7	,	,	PUNCT
eurjchem-371	14	8	since	since	SCONJ
eurjchem-371	14	9	they	they	PRON
eurjchem-371	14	10	are	be	AUX
eurjchem-371	14	11	fast	fast	ADJ
eurjchem-371	14	12	and	and	CCONJ
eurjchem-371	14	13	easy	easy	ADJ
eurjchem-371	14	14	to	to	PART
eurjchem-371	14	15	study	study	VERB
eurjchem-371	14	16	ionic	ionic	ADJ
eurjchem-371	14	17	equilibria	equilibrium	NOUN
eurjchem-371	14	18	in	in	ADP
eurjchem-371	14	19	aqueous	aqueous	ADJ
eurjchem-371	14	20	and	and	CCONJ
eurjchem-371	14	21	non‐aqueous	non‐aqueous	ADJ
eurjchem-371	14	22	solvents	solvent	NOUN
eurjchem-371	14	23	,	,	PUNCT
eurjchem-371	14	24	while	while	SCONJ
eurjchem-371	14	25	other	other	ADJ
eurjchem-371	14	26	methods	method	NOUN
eurjchem-371	14	27	such	such	ADJ
eurjchem-371	14	28	as	as	ADP
eurjchem-371	14	29	spectrophotometric	spectrophotometric	ADJ
eurjchem-371	14	30	and	and	CCONJ
eurjchem-371	14	31	conductometric	conductometric	ADJ
eurjchem-371	14	32	are	be	AUX
eurjchem-371	14	33	laborious	laborious	ADJ
eurjchem-371	14	34	,	,	PUNCT
eurjchem-371	14	35	time	time	NOUN
eurjchem-371	14	36	consuming	consume	VERB
eurjchem-371	14	37	but	but	CCONJ
eurjchem-371	14	38	they	they	PRON
eurjchem-371	14	39	are	be	AUX
eurjchem-371	14	40	very	very	ADV
eurjchem-371	14	41	accurate	accurate	ADJ
eurjchem-371	15	1	[	[	X
eurjchem-371	15	2	1‐3	1‐3	NOUN
eurjchem-371	15	3	]	]	PUNCT
eurjchem-371	15	4	.	.	PUNCT
eurjchem-371	16	1	the	the	DET
eurjchem-371	16	2	pka	pka	PROPN
eurjchem-371	16	3	value	value	NOUN
eurjchem-371	16	4	is	be	AUX
eurjchem-371	16	5	a	a	DET
eurjchem-371	16	6	key	key	ADJ
eurjchem-371	16	7	parameter	parameter	NOUN
eurjchem-371	16	8	to	to	PART
eurjchem-371	16	9	predict	predict	VERB
eurjchem-371	16	10	the	the	DET
eurjchem-371	16	11	ionization	ionization	NOUN
eurjchem-371	16	12	state	state	NOUN
eurjchem-371	16	13	of	of	ADP
eurjchem-371	16	14	a	a	DET
eurjchem-371	16	15	molecule	molecule	NOUN
eurjchem-371	16	16	with	with	ADP
eurjchem-371	16	17	respect	respect	NOUN
eurjchem-371	16	18	to	to	ADP
eurjchem-371	16	19	ph	ph	PROPN
eurjchem-371	16	20	.	.	PUNCT
eurjchem-371	17	1	the	the	DET
eurjchem-371	17	2	pka	pka	NOUN
eurjchem-371	17	3	of	of	ADP
eurjchem-371	17	4	a	a	DET
eurjchem-371	17	5	molecule	molecule	NOUN
eurjchem-371	17	6	is	be	AUX
eurjchem-371	17	7	the	the	DET
eurjchem-371	17	8	ph	ph	NOUN
eurjchem-371	17	9	at	at	ADP
eurjchem-371	17	10	which	which	PRON
eurjchem-371	17	11	the	the	DET
eurjchem-371	17	12	molecule	molecule	NOUN
eurjchem-371	17	13	is	be	AUX
eurjchem-371	17	14	50	50	NUM
eurjchem-371	17	15	%	%	NOUN
eurjchem-371	17	16	protonated	protonate	VERB
eurjchem-371	17	17	.	.	PUNCT
eurjchem-371	18	1	the	the	DET
eurjchem-371	18	2	pka	pka	NOUN
eurjchem-371	18	3	of	of	ADP
eurjchem-371	18	4	a	a	DET
eurjchem-371	18	5	molecule	molecule	NOUN
eurjchem-371	18	6	predicts	predict	VERB
eurjchem-371	18	7	the	the	DET
eurjchem-371	18	8	degree	degree	NOUN
eurjchem-371	18	9	of	of	ADP
eurjchem-371	18	10	ionisation	ionisation	NOUN
eurjchem-371	18	11	the	the	DET
eurjchem-371	18	12	molecule	molecule	NOUN
eurjchem-371	18	13	will	will	AUX
eurjchem-371	18	14	have	have	VERB
eurjchem-371	18	15	at	at	ADP
eurjchem-371	18	16	a	a	DET
eurjchem-371	18	17	particular	particular	ADJ
eurjchem-371	18	18	ph	ph	NOUN
eurjchem-371	18	19	.	.	PUNCT
eurjchem-371	19	1	since	since	SCONJ
eurjchem-371	19	2	most	most	ADJ
eurjchem-371	19	3	of	of	ADP
eurjchem-371	19	4	the	the	DET
eurjchem-371	19	5	drug	drug	NOUN
eurjchem-371	19	6	compounds	compound	NOUN
eurjchem-371	19	7	have	have	VERB
eurjchem-371	19	8	acidic	acidic	ADJ
eurjchem-371	19	9	and/or	and/or	CCONJ
eurjchem-371	19	10	basic	basic	ADJ
eurjchem-371	19	11	functionalities	functionality	NOUN
eurjchem-371	19	12	,	,	PUNCT
eurjchem-371	19	13	their	their	PRON
eurjchem-371	19	14	ionization	ionization	NOUN
eurjchem-371	19	15	state	state	NOUN
eurjchem-371	19	16	is	be	AUX
eurjchem-371	19	17	controlled	control	VERB
eurjchem-371	19	18	by	by	ADP
eurjchem-371	19	19	both	both	DET
eurjchem-371	19	20	solution	solution	NOUN
eurjchem-371	19	21	ph	ph	ADJ
eurjchem-371	19	22	and	and	CCONJ
eurjchem-371	19	23	acidic	acidic	ADJ
eurjchem-371	19	24	dissociation	dissociation	NOUN
eurjchem-371	19	25	constants	constant	NOUN
eurjchem-371	19	26	(	(	PUNCT
eurjchem-371	19	27	i.e.	i.e.	X
eurjchem-371	19	28	pka	pka	PROPN
eurjchem-371	19	29	values	value	NOUN
eurjchem-371	19	30	)	)	PUNCT
eurjchem-371	19	31	.	.	PUNCT
eurjchem-371	20	1	these	these	DET
eurjchem-371	20	2	different	different	ADJ
eurjchem-371	20	3	chemical	chemical	NOUN
eurjchem-371	20	4	species	specie	NOUN
eurjchem-371	20	5	(	(	PUNCT
eurjchem-371	20	6	cationic	cationic	ADJ
eurjchem-371	20	7	,	,	PUNCT
eurjchem-371	20	8	neutral	neutral	ADJ
eurjchem-371	20	9	,	,	PUNCT
eurjchem-371	20	10	or	or	CCONJ
eurjchem-371	20	11	anionic	anionic	NOUN
eurjchem-371	20	12	)	)	PUNCT
eurjchem-371	20	13	often	often	ADV
eurjchem-371	20	14	have	have	VERB
eurjchem-371	20	15	vastly	vastly	ADV
eurjchem-371	20	16	different	different	ADJ
eurjchem-371	20	17	properties	property	NOUN
eurjchem-371	20	18	with	with	ADP
eurjchem-371	20	19	respect	respect	NOUN
eurjchem-371	20	20	to	to	ADP
eurjchem-371	20	21	water	water	NOUN
eurjchem-371	20	22	solubility	solubility	NOUN
eurjchem-371	20	23	,	,	PUNCT
eurjchem-371	20	24	volatility	volatility	NOUN
eurjchem-371	20	25	,	,	PUNCT
eurjchem-371	20	26	uv	uv	NOUN
eurjchem-371	20	27	absorption	absorption	NOUN
eurjchem-371	20	28	,	,	PUNCT
eurjchem-371	20	29	and	and	CCONJ
eurjchem-371	20	30	reactivity	reactivity	NOUN
eurjchem-371	20	31	with	with	ADP
eurjchem-371	20	32	chemical	chemical	ADJ
eurjchem-371	20	33	oxidants	oxidant	NOUN
eurjchem-371	20	34	.	.	PUNCT
eurjchem-371	21	1	the	the	DET
eurjchem-371	21	2	ionized	ionized	ADJ
eurjchem-371	21	3	form	form	NOUN
eurjchem-371	21	4	is	be	AUX
eurjchem-371	21	5	usually	usually	ADV
eurjchem-371	21	6	more	more	ADJ
eurjchem-371	21	7	water	water	NOUN
eurjchem-371	21	8	soluble	soluble	ADJ
eurjchem-371	21	9	,	,	PUNCT
eurjchem-371	21	10	while	while	SCONJ
eurjchem-371	21	11	the	the	DET
eurjchem-371	21	12	neutral	neutral	ADJ
eurjchem-371	21	13	form	form	NOUN
eurjchem-371	21	14	is	be	AUX
eurjchem-371	21	15	more	more	ADV
eurjchem-371	21	16	lipophilic	lipophilic	ADJ
eurjchem-371	21	17	and	and	CCONJ
eurjchem-371	21	18	has	have	VERB
eurjchem-371	21	19	higher	high	ADJ
eurjchem-371	21	20	membrane	membrane	NOUN
eurjchem-371	21	21	permeability	permeability	NOUN
eurjchem-371	21	22	.	.	PUNCT
eurjchem-371	22	1	the	the	DET
eurjchem-371	22	2	extent	extent	NOUN
eurjchem-371	22	3	of	of	ADP
eurjchem-371	22	4	ionization	ionization	NOUN
eurjchem-371	22	5	is	be	AUX
eurjchem-371	22	6	one	one	NUM
eurjchem-371	22	7	of	of	ADP
eurjchem-371	22	8	several	several	ADJ
eurjchem-371	22	9	cardinal	cardinal	ADJ
eurjchem-371	22	10	properties	property	NOUN
eurjchem-371	22	11	used	use	VERB
eurjchem-371	22	12	to	to	PART
eurjchem-371	22	13	estimate	estimate	VERB
eurjchem-371	22	14	the	the	DET
eurjchem-371	22	15	absorption	absorption	NOUN
eurjchem-371	22	16	,	,	PUNCT
eurjchem-371	22	17	distribution	distribution	NOUN
eurjchem-371	22	18	,	,	PUNCT
eurjchem-371	22	19	metabolism	metabolism	NOUN
eurjchem-371	22	20	and	and	CCONJ
eurjchem-371	22	21	excretion	excretion	NOUN
eurjchem-371	22	22	of	of	ADP
eurjchem-371	22	23	compounds	compound	NOUN
eurjchem-371	22	24	in	in	ADP
eurjchem-371	22	25	biological	biological	ADJ
eurjchem-371	22	26	systems	system	NOUN
eurjchem-371	22	27	and	and	CCONJ
eurjchem-371	22	28	the	the	DET
eurjchem-371	22	29	environment	environment	NOUN
eurjchem-371	22	30	.	.	PUNCT
eurjchem-371	23	1	from	from	ADP
eurjchem-371	23	2	dissociation	dissociation	NOUN
eurjchem-371	23	3	constants	constant	NOUN
eurjchem-371	23	4	,	,	PUNCT
eurjchem-371	23	5	the	the	DET
eurjchem-371	23	6	major	major	ADJ
eurjchem-371	23	7	species	specie	NOUN
eurjchem-371	23	8	of	of	ADP
eurjchem-371	23	9	pharmaceuticals	pharmaceutical	NOUN
eurjchem-371	23	10	present	present	ADJ
eurjchem-371	23	11	in	in	ADP
eurjchem-371	23	12	the	the	DET
eurjchem-371	23	13	environment	environment	NOUN
eurjchem-371	23	14	(	(	PUNCT
eurjchem-371	23	15	usually	usually	ADV
eurjchem-371	23	16	in	in	ADP
eurjchem-371	23	17	neutral	neutral	ADJ
eurjchem-371	23	18	ph	ph	ADJ
eurjchem-371	23	19	range	range	NOUN
eurjchem-371	23	20	)	)	PUNCT
eurjchem-371	23	21	can	can	AUX
eurjchem-371	23	22	be	be	AUX
eurjchem-371	23	23	estimated	estimate	VERB
eurjchem-371	23	24	[	[	X
eurjchem-371	23	25	4,5	4,5	NUM
eurjchem-371	23	26	]	]	PUNCT
eurjchem-371	23	27	.	.	PUNCT
eurjchem-371	24	1	knowledge	knowledge	NOUN
eurjchem-371	24	2	of	of	ADP
eurjchem-371	24	3	pka	pka	PROPN
eurjchem-371	24	4	values	value	NOUN
eurjchem-371	24	5	as	as	ADP
eurjchem-371	24	6	a	a	DET
eurjchem-371	24	7	function	function	NOUN
eurjchem-371	24	8	of	of	ADP
eurjchem-371	24	9	solvent	solvent	ADJ
eurjchem-371	24	10	composition	composition	NOUN
eurjchem-371	24	11	is	be	AUX
eurjchem-371	24	12	useful	useful	ADJ
eurjchem-371	24	13	in	in	ADP
eurjchem-371	24	14	liquid	liquid	ADJ
eurjchem-371	24	15	chromatography	chromatography	NOUN
eurjchem-371	24	16	(	(	PUNCT
eurjchem-371	24	17	lc	lc	PROPN
eurjchem-371	24	18	)	)	PUNCT
eurjchem-371	24	19	or	or	CCONJ
eurjchem-371	24	20	capillary	capillary	ADJ
eurjchem-371	24	21	electrophoresis	electrophoresis	NOUN
eurjchem-371	24	22	(	(	PUNCT
eurjchem-371	24	23	ce	ce	PROPN
eurjchem-371	24	24	)	)	PUNCT
eurjchem-371	24	25	for	for	ADP
eurjchem-371	24	26	the	the	DET
eurjchem-371	24	27	separation	separation	NOUN
eurjchem-371	24	28	of	of	ADP
eurjchem-371	24	29	ionizable	ionizable	ADJ
eurjchem-371	24	30	compounds	compound	NOUN
eurjchem-371	24	31	.	.	PUNCT
eurjchem-371	25	1	the	the	DET
eurjchem-371	25	2	chromatographic	chromatographic	ADJ
eurjchem-371	25	3	retention	retention	NOUN
eurjchem-371	25	4	and	and	CCONJ
eurjchem-371	25	5	electro‐	electro‐	NUM
eurjchem-371	25	6	phoretic	phoretic	ADJ
eurjchem-371	25	7	behavior	behavior	NOUN
eurjchem-371	25	8	of	of	ADP
eurjchem-371	25	9	ionizable	ionizable	ADJ
eurjchem-371	25	10	compounds	compound	NOUN
eurjchem-371	25	11	strongly	strongly	ADV
eurjchem-371	25	12	depend	depend	VERB
eurjchem-371	25	13	on	on	ADP
eurjchem-371	25	14	the	the	DET
eurjchem-371	25	15	pka	pka	NOUN
eurjchem-371	25	16	of	of	ADP
eurjchem-371	25	17	the	the	DET
eurjchem-371	25	18	compound	compound	NOUN
eurjchem-371	25	19	and	and	CCONJ
eurjchem-371	25	20	the	the	DET
eurjchem-371	25	21	mobile‐phase	mobile‐phase	ADJ
eurjchem-371	25	22	ph	ph	NOUN
eurjchem-371	26	1	[	[	X
eurjchem-371	26	2	6,7	6,7	NUM
eurjchem-371	26	3	]	]	PUNCT
eurjchem-371	26	4	.	.	PUNCT
eurjchem-371	27	1	satisfactory	satisfactory	ADJ
eurjchem-371	27	2	knowledge	knowledge	NOUN
eurjchem-371	27	3	of	of	ADP
eurjchem-371	27	4	the	the	DET
eurjchem-371	27	5	acid	acid	ADJ
eurjchem-371	27	6	–	–	PUNCT
eurjchem-371	27	7	base	base	NOUN
eurjchem-371	27	8	behavior	behavior	NOUN
eurjchem-371	27	9	of	of	ADP
eurjchem-371	27	10	substances	substance	NOUN
eurjchem-371	27	11	in	in	ADP
eurjchem-371	27	12	hydro‐organic	hydro‐organic	ADJ
eurjchem-371	27	13	media	medium	NOUN
eurjchem-371	27	14	is	be	AUX
eurjchem-371	27	15	therefore	therefore	ADV
eurjchem-371	27	16	essential	essential	ADJ
eurjchem-371	27	17	to	to	PART
eurjchem-371	27	18	optimize	optimize	VERB
eurjchem-371	27	19	analytical	analytical	ADJ
eurjchem-371	27	20	procedures	procedure	NOUN
eurjchem-371	27	21	for	for	ADP
eurjchem-371	27	22	the	the	DET
eurjchem-371	27	23	separation	separation	NOUN
eurjchem-371	27	24	of	of	ADP
eurjchem-371	27	25	ionizable	ionizable	ADJ
eurjchem-371	27	26	compounds	compound	NOUN
eurjchem-371	27	27	by	by	ADP
eurjchem-371	27	28	lc	lc	PROPN
eurjchem-371	28	1	[	[	X
eurjchem-371	28	2	8,9	8,9	NUM
eurjchem-371	28	3	]	]	PUNCT
eurjchem-371	28	4	and	and	CCONJ
eurjchem-371	28	5	ce	ce	X
eurjchem-371	29	1	[	[	X
eurjchem-371	29	2	10	10	NUM
eurjchem-371	29	3	]	]	PUNCT
eurjchem-371	29	4	.	.	PUNCT
eurjchem-371	30	1	moreover	moreover	ADV
eurjchem-371	30	2	,	,	PUNCT
eurjchem-371	30	3	the	the	DET
eurjchem-371	30	4	acid	acid	ADJ
eurjchem-371	30	5	–	–	PUNCT
eurjchem-371	30	6	base	base	NOUN
eurjchem-371	30	7	property	property	NOUN
eurjchem-371	30	8	of	of	ADP
eurjchem-371	30	9	a	a	DET
eurjchem-371	30	10	drug	drug	NOUN
eurjchem-371	30	11	molecule	molecule	NOUN
eurjchem-371	30	12	is	be	AUX
eurjchem-371	30	13	the	the	DET
eurjchem-371	30	14	key	key	ADJ
eurjchem-371	30	15	parameter	parameter	NOUN
eurjchem-371	30	16	for	for	ADP
eurjchem-371	30	17	drug	drug	NOUN
eurjchem-371	30	18	development	development	NOUN
eurjchem-371	30	19	because	because	SCONJ
eurjchem-371	30	20	it	it	PRON
eurjchem-371	30	21	governs	govern	VERB
eurjchem-371	30	22	the	the	DET
eurjchem-371	30	23	solubility	solubility	NOUN
eurjchem-371	30	24	,	,	PUNCT
eurjchem-371	30	25	absorption	absorption	NOUN
eurjchem-371	30	26	,	,	PUNCT
eurjchem-371	30	27	distribution	distribution	NOUN
eurjchem-371	30	28	,	,	PUNCT
eurjchem-371	30	29	metabolism	metabolism	NOUN
eurjchem-371	30	30	and	and	CCONJ
eurjchem-371	30	31	elimination	elimination	NOUN
eurjchem-371	30	32	,	,	PUNCT
eurjchem-371	30	33	particularly	particularly	ADV
eurjchem-371	30	34	for	for	ADP
eurjchem-371	30	35	developing	develop	VERB
eurjchem-371	30	36	new	new	ADJ
eurjchem-371	30	37	active	active	ADJ
eurjchem-371	30	38	pharmaceutical	pharmaceutical	ADJ
eurjchem-371	30	39	ingredients	ingredient	NOUN
eurjchem-371	30	40	.	.	PUNCT
eurjchem-371	31	1	the	the	DET
eurjchem-371	31	2	transport	transport	NOUN
eurjchem-371	31	3	of	of	ADP
eurjchem-371	31	4	drugs	drug	NOUN
eurjchem-371	31	5	into	into	ADP
eurjchem-371	31	6	cells	cell	NOUN
eurjchem-371	31	7	and	and	CCONJ
eurjchem-371	31	8	across	across	ADP
eurjchem-371	31	9	other	other	ADJ
eurjchem-371	31	10	membranes	membrane	NOUN
eurjchem-371	31	11	is	be	AUX
eurjchem-371	31	12	a	a	DET
eurjchem-371	31	13	function	function	NOUN
eurjchem-371	31	14	of	of	ADP
eurjchem-371	31	15	physicochemical	physicochemical	ADJ
eurjchem-371	31	16	properties	property	NOUN
eurjchem-371	31	17	,	,	PUNCT
eurjchem-371	31	18	pka	pka	NOUN
eurjchem-371	31	19	of	of	ADP
eurjchem-371	31	20	the	the	DET
eurjchem-371	31	21	drugs	drug	NOUN
eurjchem-371	31	22	[	[	X
eurjchem-371	31	23	11	11	NUM
eurjchem-371	31	24	]	]	PUNCT
eurjchem-371	31	25	.	.	PUNCT
eurjchem-371	32	1	the	the	DET
eurjchem-371	32	2	ionization	ionization	NOUN
eurjchem-371	32	3	constant	constant	ADJ
eurjchem-371	32	4	describes	describe	VERB
eurjchem-371	32	5	the	the	DET
eurjchem-371	32	6	proportion	proportion	NOUN
eurjchem-371	32	7	of	of	ADP
eurjchem-371	32	8	different	different	ADJ
eurjchem-371	32	9	ionic	ionic	ADJ
eurjchem-371	32	10	species	specie	NOUN
eurjchem-371	32	11	in	in	ADP
eurjchem-371	32	12	which	which	PRON
eurjchem-371	32	13	the	the	DET
eurjchem-371	32	14	substance	substance	NOUN
eurjchem-371	32	15	is	be	AUX
eurjchem-371	32	16	divided	divide	VERB
eurjchem-371	32	17	at	at	ADP
eurjchem-371	32	18	different	different	ADJ
eurjchem-371	32	19	ph	ph	NOUN
eurjchem-371	32	20	.	.	PUNCT
eurjchem-371	33	1	the	the	DET
eurjchem-371	33	2	ionic	ionic	ADJ
eurjchem-371	33	3	species	specie	NOUN
eurjchem-371	33	4	differ	differ	VERB
eurjchem-371	33	5	in	in	ADP
eurjchem-371	33	6	physical	physical	ADJ
eurjchem-371	33	7	and	and	CCONJ
eurjchem-371	33	8	biological	biological	ADJ
eurjchem-371	33	9	properties	property	NOUN
eurjchem-371	33	10	[	[	X
eurjchem-371	33	11	12	12	NUM
eurjchem-371	33	12	]	]	PUNCT
eurjchem-371	33	13	.	.	PUNCT
eurjchem-371	34	1	the	the	DET
eurjchem-371	34	2	survey	survey	NOUN
eurjchem-371	34	3	of	of	ADP
eurjchem-371	34	4	literature	literature	NOUN
eurjchem-371	34	5	shows	show	VERB
eurjchem-371	34	6	that	that	SCONJ
eurjchem-371	34	7	the	the	DET
eurjchem-371	34	8	ionization	ionization	NOUN
eurjchem-371	34	9	constant	constant	ADJ
eurjchem-371	34	10	data	datum	NOUN
eurjchem-371	34	11	in	in	ADP
eurjchem-371	34	12	aqueous	aqueous	ADJ
eurjchem-371	34	13	and	and	CCONJ
eurjchem-371	34	14	non‐aqueous	non‐aqueous	ADJ
eurjchem-371	34	15	solvents	solvent	NOUN
eurjchem-371	34	16	at	at	ADP
eurjchem-371	34	17	different	different	ADJ
eurjchem-371	34	18	temperatures	temperature	NOUN
eurjchem-371	34	19	are	be	AUX
eurjchem-371	34	20	not	not	PART
eurjchem-371	34	21	frequently	frequently	ADV
eurjchem-371	34	22	available	available	ADJ
eurjchem-371	34	23	[	[	X
eurjchem-371	34	24	13,14	13,14	NUM
eurjchem-371	34	25	]	]	PUNCT
eurjchem-371	34	26	.	.	PUNCT
eurjchem-371	35	1	the	the	DET
eurjchem-371	35	2	pka	pka	PROPN
eurjchem-371	35	3	values	value	NOUN
eurjchem-371	35	4	are	be	AUX
eurjchem-371	35	5	dependent	dependent	ADJ
eurjchem-371	35	6	on	on	ADP
eurjchem-371	35	7	temperature	temperature	NOUN
eurjchem-371	35	8	and	and	CCONJ
eurjchem-371	35	9	solvent	solvent	ADJ
eurjchem-371	35	10	concentration	concentration	NOUN
eurjchem-371	35	11	and	and	CCONJ
eurjchem-371	35	12	hence	hence	ADV
eurjchem-371	35	13	these	these	DET
eurjchem-371	35	14	results	result	NOUN
eurjchem-371	35	15	are	be	AUX
eurjchem-371	35	16	very	very	ADV
eurjchem-371	35	17	important	important	ADJ
eurjchem-371	35	18	in	in	ADP
eurjchem-371	35	19	pharmaceutical	pharmaceutical	ADJ
eurjchem-371	35	20	industries	industry	NOUN
eurjchem-371	35	21	,	,	PUNCT
eurjchem-371	35	22	in	in	ADP
eurjchem-371	35	23	spectroscopy	spectroscopy	NOUN
eurjchem-371	35	24	and	and	CCONJ
eurjchem-371	35	25	in	in	ADP
eurjchem-371	35	26	biology	biology	NOUN
eurjchem-371	35	27	[	[	X
eurjchem-371	35	28	15	15	NUM
eurjchem-371	35	29	]	]	PUNCT
eurjchem-371	35	30	.	.	PUNCT
eurjchem-371	36	1	remarkable	remarkable	ADJ
eurjchem-371	36	2	developments	development	NOUN
eurjchem-371	36	3	have	have	AUX
eurjchem-371	36	4	been	be	AUX
eurjchem-371	36	5	observed	observe	VERB
eurjchem-371	36	6	in	in	ADP
eurjchem-371	36	7	the	the	DET
eurjchem-371	36	8	automation	automation	NOUN
eurjchem-371	36	9	of	of	ADP
eurjchem-371	36	10	standard	standard	ADJ
eurjchem-371	36	11	pka	pka	PROPN
eurjchem-371	36	12	determination	determination	NOUN
eurjchem-371	36	13	methods	method	NOUN
eurjchem-371	36	14	using	use	VERB
eurjchem-371	36	15	both	both	PRON
eurjchem-371	36	16	potentiometry	potentiometry	NOUN
eurjchem-371	36	17	(	(	PUNCT
eurjchem-371	36	18	glpka	glpka	NOUN
eurjchem-371	36	19	)	)	PUNCT
eurjchem-371	36	20	and	and	CCONJ
eurjchem-371	36	21	spectroscopy	spectroscopy	NOUN
eurjchem-371	36	22	(	(	PUNCT
eurjchem-371	36	23	glpka	glpka	NOUN
eurjchem-371	36	24	+	+	X
eurjchem-371	36	25	d‐pas	d‐pas	PROPN
eurjchem-371	36	26	)	)	PUNCT
eurjchem-371	37	1	[	[	X
eurjchem-371	37	2	16,17	16,17	NUM
eurjchem-371	37	3	]	]	PUNCT
eurjchem-371	37	4	.	.	PUNCT
eurjchem-371	38	1	karl	karl	PROPN
eurjchem-371	38	2	et	et	PROPN
eurjchem-371	38	3	al	al	PROPN
eurjchem-371	38	4	.	.	PROPN
eurjchem-371	38	5	,	,	PUNCT
eurjchem-371	39	1	[	[	X
eurjchem-371	39	2	18	18	NUM
eurjchem-371	39	3	]	]	PUNCT
eurjchem-371	39	4	had	have	AUX
eurjchem-371	39	5	developed	develop	VERB
eurjchem-371	39	6	a	a	DET
eurjchem-371	39	7	new	new	ADJ
eurjchem-371	39	8	method	method	NOUN
eurjchem-371	39	9	and	and	CCONJ
eurjchem-371	39	10	instrument	instrument	NOUN
eurjchem-371	39	11	(	(	PUNCT
eurjchem-371	39	12	profilersga	profilersga	PROPN
eurjchem-371	39	13	)	)	PUNCT
eurjchem-371	39	14	to	to	PART
eurjchem-371	39	15	address	address	VERB
eurjchem-371	39	16	the	the	DET
eurjchem-371	39	17	need	need	NOUN
eurjchem-371	39	18	for	for	ADP
eurjchem-371	39	19	high	high	ADJ
eurjchem-371	39	20	throughput	throughput	NOUN
eurjchem-371	39	21	measurements	measurement	NOUN
eurjchem-371	39	22	of	of	ADP
eurjchem-371	39	23	pka	pka	PROPN
eurjchem-371	39	24	.	.	PUNCT
eurjchem-371	40	1	spectral	spectral	ADJ
eurjchem-371	40	2	gradient	gradient	ADJ
eurjchem-371	40	3	analysis	analysis	NOUN
eurjchem-371	40	4	narasimham	narasimham	PROPN
eurjchem-371	40	5	and	and	CCONJ
eurjchem-371	40	6	barhate	barhate	VERB
eurjchem-371	40	7	/	/	SYM
eurjchem-371	40	8	european	european	ADJ
eurjchem-371	40	9	journal	journal	PROPN
eurjchem-371	40	10	of	of	ADP
eurjchem-371	40	11	chemistry	chemistry	NOUN
eurjchem-371	40	12	2	2	NUM
eurjchem-371	40	13	(	(	PUNCT
eurjchem-371	40	14	1	1	NUM
eurjchem-371	40	15	)	)	PUNCT
eurjchem-371	40	16	(	(	PUNCT
eurjchem-371	40	17	2011	2011	NUM
eurjchem-371	40	18	)	)	PUNCT
eurjchem-371	40	19	36‐46	36‐46	NUM
eurjchem-371	40	20	37	37	NUM
eurjchem-371	40	21	(	(	PUNCT
eurjchem-371	40	22	sga	sga	PROPN
eurjchem-371	40	23	)	)	PUNCT
eurjchem-371	40	24	is	be	AUX
eurjchem-371	40	25	suitable	suitable	ADJ
eurjchem-371	40	26	for	for	ADP
eurjchem-371	40	27	measurements	measurement	NOUN
eurjchem-371	40	28	of	of	ADP
eurjchem-371	40	29	large	large	ADJ
eurjchem-371	40	30	number	number	NOUN
eurjchem-371	40	31	of	of	ADP
eurjchem-371	40	32	compounds	compound	NOUN
eurjchem-371	40	33	using	use	VERB
eurjchem-371	40	34	small	small	ADJ
eurjchem-371	40	35	amounts	amount	NOUN
eurjchem-371	40	36	of	of	ADP
eurjchem-371	40	37	samples	sample	NOUN
eurjchem-371	40	38	,	,	PUNCT
eurjchem-371	40	39	a	a	DET
eurjchem-371	40	40	typical	typical	ADJ
eurjchem-371	40	41	requirement	requirement	NOUN
eurjchem-371	40	42	of	of	ADP
eurjchem-371	40	43	early	early	ADJ
eurjchem-371	40	44	phase	phase	NOUN
eurjchem-371	40	45	drug	drug	NOUN
eurjchem-371	40	46	discovery	discovery	NOUN
eurjchem-371	40	47	.	.	PUNCT
eurjchem-371	41	1	evaluation	evaluation	NOUN
eurjchem-371	41	2	of	of	ADP
eurjchem-371	41	3	aqueous	aqueous	ADJ
eurjchem-371	41	4	dissociation	dissociation	NOUN
eurjchem-371	41	5	constants	constant	NOUN
eurjchem-371	41	6	is	be	AUX
eurjchem-371	41	7	an	an	DET
eurjchem-371	41	8	unavoidable	unavoidable	ADJ
eurjchem-371	41	9	requirement	requirement	NOUN
eurjchem-371	41	10	in	in	ADP
eurjchem-371	41	11	routine	routine	ADJ
eurjchem-371	41	12	drug	drug	NOUN
eurjchem-371	41	13	development	development	NOUN
eurjchem-371	41	14	.	.	PUNCT
eurjchem-371	42	1	however	however	ADV
eurjchem-371	42	2	,	,	PUNCT
eurjchem-371	42	3	many	many	ADJ
eurjchem-371	42	4	drugs	drug	NOUN
eurjchem-371	42	5	are	be	AUX
eurjchem-371	42	6	sparingly	sparingly	ADV
eurjchem-371	42	7	soluble	soluble	ADJ
eurjchem-371	42	8	in	in	ADP
eurjchem-371	42	9	water	water	NOUN
eurjchem-371	42	10	and	and	CCONJ
eurjchem-371	42	11	any	any	DET
eurjchem-371	42	12	experimental	experimental	ADJ
eurjchem-371	42	13	pka	pka	PROPN
eurjchem-371	42	14	determination	determination	NOUN
eurjchem-371	42	15	requires	require	VERB
eurjchem-371	42	16	the	the	DET
eurjchem-371	42	17	use	use	NOUN
eurjchem-371	42	18	of	of	ADP
eurjchem-371	42	19	an	an	DET
eurjchem-371	42	20	organic	organic	ADJ
eurjchem-371	42	21	or	or	CCONJ
eurjchem-371	42	22	hydro	hydro	NOUN
eurjchem-371	42	23	organic	organic	ADJ
eurjchem-371	42	24	solvent	solvent	NOUN
eurjchem-371	42	25	.	.	PUNCT
eurjchem-371	43	1	the	the	DET
eurjchem-371	43	2	mixed‐solvent	mixed‐solvent	NOUN
eurjchem-371	43	3	procedure	procedure	NOUN
eurjchem-371	43	4	mainly	mainly	ADV
eurjchem-371	43	5	using	use	VERB
eurjchem-371	43	6	methanol	methanol	NOUN
eurjchem-371	43	7	–	–	PUNCT
eurjchem-371	43	8	water	water	NOUN
eurjchem-371	43	9	mixtures	mixture	NOUN
eurjchem-371	43	10	provides	provide	VERB
eurjchem-371	43	11	a	a	DET
eurjchem-371	43	12	good	good	ADJ
eurjchem-371	43	13	alternative	alternative	NOUN
eurjchem-371	43	14	for	for	ADP
eurjchem-371	43	15	sparingly	sparingly	ADV
eurjchem-371	43	16	soluble	soluble	ADJ
eurjchem-371	43	17	compounds	compound	NOUN
eurjchem-371	43	18	[	[	X
eurjchem-371	43	19	19‐21	19‐21	NUM
eurjchem-371	43	20	]	]	PUNCT
eurjchem-371	43	21	.	.	PUNCT
eurjchem-371	44	1	here	here	ADV
eurjchem-371	44	2	,	,	PUNCT
eurjchem-371	44	3	the	the	DET
eurjchem-371	44	4	cosolvent	cosolvent	ADJ
eurjchem-371	44	5	ionization	ionization	NOUN
eurjchem-371	44	6	constants	constant	NOUN
eurjchem-371	44	7	(	(	PUNCT
eurjchem-371	44	8	pska	pska	NOUN
eurjchem-371	44	9	)	)	PUNCT
eurjchem-371	44	10	in	in	ADP
eurjchem-371	44	11	different	different	ADJ
eurjchem-371	44	12	ratios	ratio	NOUN
eurjchem-371	44	13	of	of	ADP
eurjchem-371	44	14	methanol	methanol	NOUN
eurjchem-371	44	15	–	–	PUNCT
eurjchem-371	44	16	water	water	NOUN
eurjchem-371	44	17	mixtures	mixture	NOUN
eurjchem-371	44	18	are	be	AUX
eurjchem-371	44	19	measured	measure	VERB
eurjchem-371	44	20	and	and	CCONJ
eurjchem-371	44	21	the	the	DET
eurjchem-371	44	22	aqueous	aqueous	ADJ
eurjchem-371	44	23	pka	pka	PROPN
eurjchem-371	44	24	is	be	AUX
eurjchem-371	44	25	obtained	obtain	VERB
eurjchem-371	44	26	by	by	ADP
eurjchem-371	44	27	extrapolation	extrapolation	NOUN
eurjchem-371	44	28	.	.	PUNCT
eurjchem-371	45	1	a	a	DET
eurjchem-371	45	2	critical	critical	ADJ
eurjchem-371	45	3	evaluation	evaluation	NOUN
eurjchem-371	45	4	of	of	ADP
eurjchem-371	45	5	different	different	ADJ
eurjchem-371	45	6	extrapolation	extrapolation	NOUN
eurjchem-371	45	7	approaches	approach	NOUN
eurjchem-371	45	8	for	for	ADP
eurjchem-371	45	9	compounds	compound	NOUN
eurjchem-371	45	10	poorly	poorly	ADV
eurjchem-371	45	11	soluble	soluble	ADJ
eurjchem-371	45	12	in	in	ADP
eurjchem-371	45	13	water	water	NOUN
eurjchem-371	45	14	should	should	AUX
eurjchem-371	45	15	be	be	AUX
eurjchem-371	45	16	very	very	ADV
eurjchem-371	45	17	useful	useful	ADJ
eurjchem-371	45	18	in	in	ADP
eurjchem-371	45	19	drug	drug	NOUN
eurjchem-371	45	20	screening	screen	VERB
eurjchem-371	45	21	technology	technology	NOUN
eurjchem-371	45	22	.	.	PUNCT
eurjchem-371	46	1	to	to	PART
eurjchem-371	46	2	overcome	overcome	VERB
eurjchem-371	46	3	the	the	DET
eurjchem-371	46	4	difficulty	difficulty	NOUN
eurjchem-371	46	5	and	and	CCONJ
eurjchem-371	46	6	improve	improve	VERB
eurjchem-371	46	7	the	the	DET
eurjchem-371	46	8	solubility	solubility	NOUN
eurjchem-371	46	9	of	of	ADP
eurjchem-371	46	10	drug	drug	NOUN
eurjchem-371	46	11	compounds	compound	NOUN
eurjchem-371	46	12	,	,	PUNCT
eurjchem-371	46	13	g.	g.	PROPN
eurjchem-371	46	14	volgyi	volgyi	PROPN
eurjchem-371	46	15	et	et	PROPN
eurjchem-371	46	16	al	al	PROPN
eurjchem-371	46	17	.	.	PUNCT
eurjchem-371	47	1	[	[	X
eurjchem-371	47	2	22	22	NUM
eurjchem-371	47	3	]	]	PUNCT
eurjchem-371	47	4	have	have	AUX
eurjchem-371	47	5	developed	develop	VERB
eurjchem-371	47	6	and	and	CCONJ
eurjchem-371	47	7	validated	validate	VERB
eurjchem-371	47	8	a	a	DET
eurjchem-371	47	9	new	new	ADJ
eurjchem-371	47	10	single	single	ADJ
eurjchem-371	47	11	,	,	PUNCT
eurjchem-371	47	12	multicomponent	multicomponent	ADJ
eurjchem-371	47	13	cosolvent	cosolvent	ADJ
eurjchem-371	47	14	mixture	mixture	NOUN
eurjchem-371	47	15	consisting	consist	VERB
eurjchem-371	47	16	of	of	ADP
eurjchem-371	47	17	equal	equal	ADJ
eurjchem-371	47	18	volumes	volume	NOUN
eurjchem-371	47	19	of	of	ADP
eurjchem-371	47	20	methanol	methanol	NOUN
eurjchem-371	47	21	,	,	PUNCT
eurjchem-371	47	22	acetonitrile	acetonitrile	NOUN
eurjchem-371	47	23	and	and	CCONJ
eurjchem-371	47	24	dioxane	dioxane	NOUN
eurjchem-371	47	25	for	for	ADP
eurjchem-371	47	26	an	an	DET
eurjchem-371	47	27	efficient	efficient	ADJ
eurjchem-371	47	28	pka	pka	PROPN
eurjchem-371	47	29	measurement	measurement	NOUN
eurjchem-371	47	30	.	.	PUNCT
eurjchem-371	48	1	however	however	ADV
eurjchem-371	48	2	,	,	PUNCT
eurjchem-371	48	3	none	none	NOUN
eurjchem-371	48	4	of	of	ADP
eurjchem-371	48	5	these	these	DET
eurjchem-371	48	6	literature	literature	NOUN
eurjchem-371	48	7	surveys	survey	NOUN
eurjchem-371	48	8	have	have	AUX
eurjchem-371	48	9	shown	show	VERB
eurjchem-371	48	10	any	any	DET
eurjchem-371	48	11	systematic	systematic	ADJ
eurjchem-371	48	12	study	study	NOUN
eurjchem-371	48	13	of	of	ADP
eurjchem-371	48	14	temperature	temperature	NOUN
eurjchem-371	48	15	,	,	PUNCT
eurjchem-371	48	16	ionic	ionic	ADJ
eurjchem-371	48	17	strength	strength	NOUN
eurjchem-371	48	18	and	and	CCONJ
eurjchem-371	48	19	dielectric	dielectric	ADJ
eurjchem-371	48	20	constant	constant	ADJ
eurjchem-371	48	21	effect	effect	NOUN
eurjchem-371	48	22	on	on	ADP
eurjchem-371	48	23	the	the	DET
eurjchem-371	48	24	dissociation	dissociation	NOUN
eurjchem-371	48	25	constant	constant	ADJ
eurjchem-371	48	26	of	of	ADP
eurjchem-371	48	27	drug	drug	NOUN
eurjchem-371	48	28	compounds	compound	NOUN
eurjchem-371	48	29	.	.	PUNCT
eurjchem-371	49	1	in	in	ADP
eurjchem-371	49	2	this	this	DET
eurjchem-371	49	3	work	work	NOUN
eurjchem-371	49	4	,	,	PUNCT
eurjchem-371	49	5	we	we	PRON
eurjchem-371	49	6	performed	perform	VERB
eurjchem-371	49	7	a	a	DET
eurjchem-371	49	8	systematic	systematic	ADJ
eurjchem-371	49	9	validation	validation	NOUN
eurjchem-371	49	10	to	to	PART
eurjchem-371	49	11	evaluate	evaluate	VERB
eurjchem-371	49	12	the	the	DET
eurjchem-371	49	13	pka	pka	PROPN
eurjchem-371	49	14	values	value	NOUN
eurjchem-371	49	15	to	to	PART
eurjchem-371	49	16	understand	understand	VERB
eurjchem-371	49	17	the	the	DET
eurjchem-371	49	18	effect	effect	NOUN
eurjchem-371	49	19	of	of	ADP
eurjchem-371	49	20	dielectric	dielectric	ADJ
eurjchem-371	49	21	constant	constant	ADJ
eurjchem-371	49	22	in	in	ADP
eurjchem-371	49	23	different	different	ADJ
eurjchem-371	49	24	co‐solvents	co‐solvent	NOUN
eurjchem-371	49	25	(	(	PUNCT
eurjchem-371	49	26	methanol	methanol	NOUN
eurjchem-371	49	27	,	,	PUNCT
eurjchem-371	49	28	ethanol	ethanol	NOUN
eurjchem-371	49	29	,	,	PUNCT
eurjchem-371	49	30	1,4‐	1,4‐	NUM
eurjchem-371	49	31	dioxane	dioxane	NOUN
eurjchem-371	49	32	and	and	CCONJ
eurjchem-371	49	33	acetonitrile	acetonitrile	NOUN
eurjchem-371	49	34	)	)	PUNCT
eurjchem-371	49	35	,	,	PUNCT
eurjchem-371	49	36	temperature	temperature	NOUN
eurjchem-371	49	37	and	and	CCONJ
eurjchem-371	49	38	ionic	ionic	ADJ
eurjchem-371	49	39	strength	strength	NOUN
eurjchem-371	49	40	using	use	VERB
eurjchem-371	49	41	some	some	PRON
eurjchem-371	49	42	of	of	ADP
eurjchem-371	49	43	beta‐blockers	beta‐blocker	NOUN
eurjchem-371	49	44	and	and	CCONJ
eurjchem-371	49	45	antidiabetic	antidiabetic	ADJ
eurjchem-371	49	46	drug	drug	NOUN
eurjchem-371	49	47	compounds	compound	NOUN
eurjchem-371	49	48	.	.	PUNCT
eurjchem-371	50	1	the	the	DET
eurjchem-371	50	2	pka	pka	PROPN
eurjchem-371	50	3	of	of	ADP
eurjchem-371	50	4	selected	select	VERB
eurjchem-371	50	5	drugs	drug	NOUN
eurjchem-371	50	6	were	be	AUX
eurjchem-371	50	7	determined	determine	VERB
eurjchem-371	50	8	by	by	ADP
eurjchem-371	50	9	potentiometric	potentiometric	ADJ
eurjchem-371	50	10	titration	titration	NOUN
eurjchem-371	50	11	between	between	ADP
eurjchem-371	50	12	6	6	NUM
eurjchem-371	50	13	and	and	CCONJ
eurjchem-371	50	14	60	60	NUM
eurjchem-371	50	15	%	%	NOUN
eurjchem-371	50	16	of	of	ADP
eurjchem-371	50	17	selected	select	VERB
eurjchem-371	50	18	solvents	solvent	NOUN
eurjchem-371	50	19	at	at	ADP
eurjchem-371	50	20	25	25	NUM
eurjchem-371	50	21	oc	oc	NOUN
eurjchem-371	50	22	and	and	CCONJ
eurjchem-371	50	23	in	in	ADP
eurjchem-371	50	24	0.15	0.15	NUM
eurjchem-371	50	25	m	m	NOUN
eurjchem-371	50	26	ionic	ionic	ADJ
eurjchem-371	50	27	strength	strength	NOUN
eurjchem-371	50	28	using	use	VERB
eurjchem-371	50	29	kcl	kcl	PROPN
eurjchem-371	50	30	.	.	PUNCT
eurjchem-371	51	1	temperature	temperature	NOUN
eurjchem-371	51	2	effect	effect	NOUN
eurjchem-371	51	3	on	on	ADP
eurjchem-371	51	4	selected	select	VERB
eurjchem-371	51	5	drugs	drug	NOUN
eurjchem-371	51	6	is	be	AUX
eurjchem-371	51	7	studied	study	VERB
eurjchem-371	51	8	between	between	ADP
eurjchem-371	51	9	25	25	NUM
eurjchem-371	51	10	oc	oc	NOUN
eurjchem-371	51	11	and	and	CCONJ
eurjchem-371	51	12	45	45	NUM
eurjchem-371	51	13	oc	oc	NOUN
eurjchem-371	51	14	while	while	SCONJ
eurjchem-371	51	15	ionic	ionic	ADJ
eurjchem-371	51	16	strength	strength	NOUN
eurjchem-371	51	17	effect	effect	NOUN
eurjchem-371	51	18	is	be	AUX
eurjchem-371	51	19	studied	study	VERB
eurjchem-371	51	20	between	between	ADP
eurjchem-371	51	21	0.15	0.15	NUM
eurjchem-371	51	22	m	m	NOUN
eurjchem-371	51	23	and	and	CCONJ
eurjchem-371	51	24	0.50	0.50	NUM
eurjchem-371	51	25	m.	m.	NOUN
eurjchem-371	51	26	spectrophotometric	spectrophotometric	ADJ
eurjchem-371	51	27	technique	technique	NOUN
eurjchem-371	51	28	was	be	AUX
eurjchem-371	51	29	also	also	ADV
eurjchem-371	51	30	applied	apply	VERB
eurjchem-371	51	31	under	under	ADP
eurjchem-371	51	32	similar	similar	ADJ
eurjchem-371	51	33	conditions	condition	NOUN
eurjchem-371	51	34	on	on	ADP
eurjchem-371	51	35	those	those	DET
eurjchem-371	51	36	compounds	compound	NOUN
eurjchem-371	51	37	which	which	PRON
eurjchem-371	51	38	has	have	VERB
eurjchem-371	51	39	a	a	DET
eurjchem-371	51	40	ph‐dependent	ph‐dependent	NOUN
eurjchem-371	51	41	uv	uv	NOUN
eurjchem-371	51	42	spectrum	spectrum	NOUN
eurjchem-371	51	43	(	(	PUNCT
eurjchem-371	51	44	amiloride	amiloride	ADJ
eurjchem-371	51	45	hydrochloride	hydrochloride	NOUN
eurjchem-371	51	46	,	,	PUNCT
eurjchem-371	51	47	atenolol	atenolol	PROPN
eurjchem-371	51	48	,	,	PUNCT
eurjchem-371	51	49	propranolol	propranolol	NOUN
eurjchem-371	51	50	hydrochloride	hydrochloride	NOUN
eurjchem-371	51	51	and	and	CCONJ
eurjchem-371	51	52	gliclazide	gliclazide	NOUN
eurjchem-371	51	53	)	)	PUNCT
eurjchem-371	51	54	.	.	PUNCT
eurjchem-371	52	1	the	the	DET
eurjchem-371	52	2	main	main	ADJ
eurjchem-371	52	3	objective	objective	NOUN
eurjchem-371	52	4	of	of	ADP
eurjchem-371	52	5	our	our	PRON
eurjchem-371	52	6	present	present	ADJ
eurjchem-371	52	7	work	work	NOUN
eurjchem-371	52	8	was	be	AUX
eurjchem-371	52	9	to	to	PART
eurjchem-371	52	10	study	study	VERB
eurjchem-371	52	11	the	the	DET
eurjchem-371	52	12	effect	effect	NOUN
eurjchem-371	52	13	of	of	ADP
eurjchem-371	52	14	co‐solvents	co‐solvent	NOUN
eurjchem-371	52	15	at	at	ADP
eurjchem-371	52	16	various	various	ADJ
eurjchem-371	52	17	temperatures	temperature	NOUN
eurjchem-371	52	18	and	and	CCONJ
eurjchem-371	52	19	ionic	ionic	ADJ
eurjchem-371	52	20	strength	strength	NOUN
eurjchem-371	52	21	on	on	ADP
eurjchem-371	52	22	some	some	PRON
eurjchem-371	52	23	of	of	ADP
eurjchem-371	52	24	beta	beta	ADJ
eurjchem-371	52	25	blockers	blocker	NOUN
eurjchem-371	52	26	(	(	PUNCT
eurjchem-371	52	27	amiloride	amiloride	ADV
eurjchem-371	52	28	,	,	PUNCT
eurjchem-371	52	29	propranolol	propranolol	PROPN
eurjchem-371	52	30	,	,	PUNCT
eurjchem-371	52	31	atenolol	atenolol	PROPN
eurjchem-371	52	32	,	,	PUNCT
eurjchem-371	52	33	metoprolol	metoprolol	NOUN
eurjchem-371	52	34	and	and	CCONJ
eurjchem-371	52	35	amlodipine	amlodipine	NOUN
eurjchem-371	52	36	)	)	PUNCT
eurjchem-371	52	37	and	and	CCONJ
eurjchem-371	52	38	anti‐diabetic	anti‐diabetic	ADJ
eurjchem-371	52	39	drugs	drug	NOUN
eurjchem-371	52	40	(	(	PUNCT
eurjchem-371	52	41	gliclazide	gliclazide	NOUN
eurjchem-371	52	42	,	,	PUNCT
eurjchem-371	52	43	glipizide	glipizide	ADJ
eurjchem-371	52	44	and	and	CCONJ
eurjchem-371	52	45	pioglitazone	pioglitazone	NOUN
eurjchem-371	52	46	)	)	PUNCT
eurjchem-371	52	47	and	and	CCONJ
eurjchem-371	52	48	compare	compare	VERB
eurjchem-371	52	49	the	the	DET
eurjchem-371	52	50	extrapolated	extrapolated	ADJ
eurjchem-371	52	51	dissociation	dissociation	NOUN
eurjchem-371	52	52	constants	constant	NOUN
eurjchem-371	52	53	(	(	PUNCT
eurjchem-371	52	54	pka	pka	NOUN
eurjchem-371	52	55	)	)	PUNCT
eurjchem-371	52	56	results	result	VERB
eurjchem-371	52	57	with	with	ADP
eurjchem-371	52	58	those	those	PRON
eurjchem-371	52	59	determined	determine	VERB
eurjchem-371	52	60	in	in	ADP
eurjchem-371	52	61	aqueous	aqueous	ADJ
eurjchem-371	52	62	medium	medium	NOUN
eurjchem-371	52	63	or	or	CCONJ
eurjchem-371	52	64	with	with	ADP
eurjchem-371	52	65	literature	literature	NOUN
eurjchem-371	52	66	values	value	NOUN
eurjchem-371	52	67	.	.	PUNCT
eurjchem-371	53	1	the	the	DET
eurjchem-371	53	2	present	present	ADJ
eurjchem-371	53	3	study	study	NOUN
eurjchem-371	53	4	also	also	ADV
eurjchem-371	53	5	includes	include	VERB
eurjchem-371	53	6	the	the	DET
eurjchem-371	53	7	determination	determination	NOUN
eurjchem-371	53	8	of	of	ADP
eurjchem-371	53	9	partition	partition	NOUN
eurjchem-371	53	10	co‐efficient	co‐efficient	NOUN
eurjchem-371	53	11	(	(	PUNCT
eurjchem-371	53	12	log	log	VERB
eurjchem-371	53	13	p	p	NOUN
eurjchem-371	53	14	)	)	PUNCT
eurjchem-371	53	15	of	of	ADP
eurjchem-371	53	16	all	all	DET
eurjchem-371	53	17	the	the	DET
eurjchem-371	53	18	selected	select	VERB
eurjchem-371	53	19	drugs	drug	NOUN
eurjchem-371	53	20	(	(	PUNCT
eurjchem-371	53	21	except	except	SCONJ
eurjchem-371	53	22	that	that	DET
eurjchem-371	53	23	pioglitazone	pioglitazone	NOUN
eurjchem-371	53	24	was	be	AUX
eurjchem-371	53	25	replaced	replace	VERB
eurjchem-371	53	26	with	with	ADP
eurjchem-371	53	27	glibenclamide	glibenclamide	NOUN
eurjchem-371	53	28	)	)	PUNCT
eurjchem-371	53	29	in	in	ADP
eurjchem-371	53	30	octanol	octanol	NOUN
eurjchem-371	53	31	/	/	SYM
eurjchem-371	53	32	water	water	NOUN
eurjchem-371	53	33	system	system	NOUN
eurjchem-371	53	34	of	of	ADP
eurjchem-371	53	35	all	all	DET
eurjchem-371	53	36	the	the	DET
eurjchem-371	53	37	selected	select	VERB
eurjchem-371	53	38	drugs	drug	NOUN
eurjchem-371	53	39	using	use	VERB
eurjchem-371	53	40	automated	automate	VERB
eurjchem-371	53	41	potentiometric	potentiometric	ADJ
eurjchem-371	53	42	titrator	titrator	NOUN
eurjchem-371	53	43	(	(	PUNCT
eurjchem-371	53	44	glpka	glpka	NOUN
eurjchem-371	53	45	)	)	PUNCT
eurjchem-371	53	46	and	and	CCONJ
eurjchem-371	53	47	compares	compare	VERB
eurjchem-371	53	48	the	the	DET
eurjchem-371	53	49	available	available	ADJ
eurjchem-371	53	50	percentage	percentage	NOUN
eurjchem-371	53	51	species	specie	NOUN
eurjchem-371	53	52	at	at	ADP
eurjchem-371	53	53	physiological	physiological	ADJ
eurjchem-371	53	54	ph	ph	NOUN
eurjchem-371	53	55	.	.	PUNCT
eurjchem-371	54	1	this	this	DET
eurjchem-371	54	2	paper	paper	NOUN
eurjchem-371	54	3	deals	deal	NOUN
eurjchem-371	54	4	with	with	ADP
eurjchem-371	54	5	the	the	DET
eurjchem-371	54	6	comparison	comparison	NOUN
eurjchem-371	54	7	of	of	ADP
eurjchem-371	54	8	pska	pska	NOUN
eurjchem-371	54	9	of	of	ADP
eurjchem-371	54	10	drug	drug	NOUN
eurjchem-371	54	11	compounds	compound	NOUN
eurjchem-371	54	12	determined	determine	VERB
eurjchem-371	54	13	by	by	ADP
eurjchem-371	54	14	ph	ph	ADJ
eurjchem-371	54	15	metry	metry	NOUN
eurjchem-371	54	16	and	and	CCONJ
eurjchem-371	54	17	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	54	18	methods	method	NOUN
eurjchem-371	54	19	.	.	PUNCT
eurjchem-371	55	1	2	2	X
eurjchem-371	55	2	.	.	X
eurjchem-371	55	3	experimental	experimental	ADJ
eurjchem-371	55	4	2.1	2.1	NUM
eurjchem-371	55	5	.	.	PUNCT
eurjchem-371	55	6	instrumentation	instrumentation	NOUN
eurjchem-371	55	7	2.1.1	2.1.1	NUM
eurjchem-371	55	8	.	.	PUNCT
eurjchem-371	56	1	potentiometric	potentiometric	PROPN
eurjchem-371	56	2	pka	pka	PROPN
eurjchem-371	56	3	determination	determination	NOUN
eurjchem-371	56	4	glpka	glpka	PROPN
eurjchem-371	56	5	automated	automate	VERB
eurjchem-371	56	6	pka	pka	PROPN
eurjchem-371	56	7	analyser	analyser	NOUN
eurjchem-371	56	8	(	(	PUNCT
eurjchem-371	56	9	sirius	sirius	PROPN
eurjchem-371	56	10	analytical	analytical	PROPN
eurjchem-371	56	11	instruments	instruments	PROPN
eurjchem-371	56	12	ltd	ltd	PROPN
eurjchem-371	56	13	.	.	PROPN
eurjchem-371	56	14	,	,	PUNCT
eurjchem-371	56	15	forest	forest	NOUN
eurjchem-371	56	16	row	row	NOUN
eurjchem-371	56	17	,	,	PUNCT
eurjchem-371	56	18	uk	uk	PROPN
eurjchem-371	56	19	)	)	PUNCT
eurjchem-371	56	20	fitted	fit	VERB
eurjchem-371	56	21	with	with	ADP
eurjchem-371	56	22	combination	combination	NOUN
eurjchem-371	56	23	ag	ag	PROPN
eurjchem-371	56	24	/	/	SYM
eurjchem-371	56	25	agcl	agcl	NOUN
eurjchem-371	56	26	ph	ph	NOUN
eurjchem-371	56	27	electrode	electrode	NOUN
eurjchem-371	56	28	was	be	AUX
eurjchem-371	56	29	used	use	VERB
eurjchem-371	56	30	for	for	ADP
eurjchem-371	56	31	determination	determination	NOUN
eurjchem-371	56	32	of	of	ADP
eurjchem-371	56	33	dissociation	dissociation	NOUN
eurjchem-371	56	34	constants	constant	NOUN
eurjchem-371	56	35	.	.	PUNCT
eurjchem-371	57	1	the	the	DET
eurjchem-371	57	2	pka	pka	PROPN
eurjchem-371	57	3	and	and	CCONJ
eurjchem-371	57	4	pska	pska	NOUN
eurjchem-371	57	5	values	value	NOUN
eurjchem-371	57	6	were	be	AUX
eurjchem-371	57	7	calculated	calculate	VERB
eurjchem-371	57	8	by	by	ADP
eurjchem-371	57	9	refinementprotm	refinementprotm	ADJ
eurjchem-371	57	10	software	software	NOUN
eurjchem-371	57	11	(	(	PUNCT
eurjchem-371	57	12	sirius	sirius	PROPN
eurjchem-371	57	13	analytical	analytical	PROPN
eurjchem-371	57	14	instruments	instruments	PROPN
eurjchem-371	57	15	ltd	ltd	PROPN
eurjchem-371	57	16	.	.	PROPN
eurjchem-371	57	17	,	,	PUNCT
eurjchem-371	57	18	forest	forest	NOUN
eurjchem-371	57	19	row	row	NOUN
eurjchem-371	57	20	,	,	PUNCT
eurjchem-371	57	21	uk	uk	PROPN
eurjchem-371	57	22	)	)	PUNCT
eurjchem-371	57	23	.	.	PUNCT
eurjchem-371	58	1	2.1.2	2.1.2	X
eurjchem-371	58	2	.	.	PUNCT
eurjchem-371	58	3	electrode	electrode	NOUN
eurjchem-371	58	4	calibration	calibration	NOUN
eurjchem-371	58	5	the	the	DET
eurjchem-371	58	6	four‐plus	four‐plus	ADJ
eurjchem-371	58	7	parameter	parameter	NOUN
eurjchem-371	58	8	technique	technique	NOUN
eurjchem-371	59	1	[	[	X
eurjchem-371	59	2	19,23,25	19,23,25	NUM
eurjchem-371	59	3	]	]	PUNCT
eurjchem-371	59	4	was	be	AUX
eurjchem-371	59	5	used	use	VERB
eurjchem-371	59	6	for	for	ADP
eurjchem-371	59	7	electrode	electrode	ADJ
eurjchem-371	59	8	calibration	calibration	NOUN
eurjchem-371	59	9	in	in	ADP
eurjchem-371	59	10	both	both	CCONJ
eurjchem-371	59	11	aqueous	aqueous	ADJ
eurjchem-371	59	12	medium	medium	NOUN
eurjchem-371	59	13	and	and	CCONJ
eurjchem-371	59	14	co	co	ADJ
eurjchem-371	59	15	solvent	solvent	ADJ
eurjchem-371	59	16	mixtures	mixture	NOUN
eurjchem-371	59	17	.	.	PUNCT
eurjchem-371	60	1	hcl	hcl	PROPN
eurjchem-371	60	2	solutions	solution	NOUN
eurjchem-371	60	3	of	of	ADP
eurjchem-371	60	4	known	know	VERB
eurjchem-371	60	5	concentration	concentration	NOUN
eurjchem-371	60	6	,	,	PUNCT
eurjchem-371	60	7	containing	contain	VERB
eurjchem-371	60	8	6	6	NUM
eurjchem-371	60	9	–	–	SYM
eurjchem-371	60	10	60	60	NUM
eurjchem-371	60	11	wt%	wt%	VERB
eurjchem-371	60	12	selected	select	VERB
eurjchem-371	60	13	co	co	NOUN
eurjchem-371	60	14	solvents‐water	solvents‐water	PROPN
eurjchem-371	60	15	mixtures	mixture	NOUN
eurjchem-371	60	16	were	be	AUX
eurjchem-371	60	17	titrated	titrate	VERB
eurjchem-371	60	18	with	with	ADP
eurjchem-371	60	19	standardized	standardized	ADJ
eurjchem-371	60	20	koh	koh	PROPN
eurjchem-371	60	21	at	at	ADP
eurjchem-371	60	22	constant	constant	ADJ
eurjchem-371	60	23	ionic	ionic	ADJ
eurjchem-371	60	24	strength	strength	NOUN
eurjchem-371	60	25	(	(	PUNCT
eurjchem-371	60	26	i	i	NOUN
eurjchem-371	60	27	=	=	NOUN
eurjchem-371	60	28	0.15	0.15	NUM
eurjchem-371	60	29	m	m	AUX
eurjchem-371	60	30	using	use	VERB
eurjchem-371	60	31	kcl	kcl	NOUN
eurjchem-371	60	32	)	)	PUNCT
eurjchem-371	60	33	and	and	CCONJ
eurjchem-371	60	34	temperature	temperature	NOUN
eurjchem-371	60	35	(	(	PUNCT
eurjchem-371	60	36	25.0±0.5	25.0±0.5	NUM
eurjchem-371	60	37	°	°	NOUN
eurjchem-371	60	38	c	c	NOUN
eurjchem-371	60	39	)	)	PUNCT
eurjchem-371	60	40	,	,	PUNCT
eurjchem-371	60	41	under	under	ADP
eurjchem-371	60	42	argon	argon	NOUN
eurjchem-371	60	43	atmosphere	atmosphere	NOUN
eurjchem-371	60	44	,	,	PUNCT
eurjchem-371	60	45	from	from	ADP
eurjchem-371	60	46	ph	ph	PROPN
eurjchem-371	60	47	1.8	1.8	NUM
eurjchem-371	60	48	to	to	PART
eurjchem-371	60	49	12.0	12.0	NUM
eurjchem-371	60	50	without	without	ADP
eurjchem-371	60	51	any	any	DET
eurjchem-371	60	52	sample	sample	NOUN
eurjchem-371	60	53	present	present	ADJ
eurjchem-371	60	54	(	(	PUNCT
eurjchem-371	60	55	“	"	PUNCT
eurjchem-371	60	56	blank	blank	ADJ
eurjchem-371	60	57	”	"	PUNCT
eurjchem-371	60	58	titration	titration	NOUN
eurjchem-371	60	59	)	)	PUNCT
eurjchem-371	60	60	.	.	PUNCT
eurjchem-371	61	1	the	the	DET
eurjchem-371	61	2	operational	operational	ADJ
eurjchem-371	61	3	ph	ph	ADJ
eurjchem-371	61	4	reading	reading	NOUN
eurjchem-371	61	5	was	be	AUX
eurjchem-371	61	6	related	relate	VERB
eurjchem-371	61	7	to	to	ADP
eurjchem-371	61	8	the	the	DET
eurjchem-371	61	9	concentration	concentration	NOUN
eurjchem-371	61	10	pch	pch	ADJ
eurjchem-371	61	11	values	value	NOUN
eurjchem-371	61	12	by	by	ADP
eurjchem-371	61	13	a	a	DET
eurjchem-371	61	14	multi	multi	ADJ
eurjchem-371	61	15	parametric	parametric	ADJ
eurjchem-371	61	16	equation	equation	NOUN
eurjchem-371	61	17	.	.	PUNCT
eurjchem-371	62	1	ph	ph	PROPN
eurjchem-371	62	2	p	p	PROPN
eurjchem-371	62	3	h	h	NOUN
eurjchem-371	62	4	h	h	NOUN
eurjchem-371	63	1	oh	oh	INTJ
eurjchem-371	63	2	(	(	PUNCT
eurjchem-371	63	3	1	1	X
eurjchem-371	63	4	)	)	PUNCT
eurjchem-371	63	5	the	the	DET
eurjchem-371	63	6	parameters	parameter	NOUN
eurjchem-371	63	7	are	be	AUX
eurjchem-371	63	8	determined	determine	VERB
eurjchem-371	63	9	by	by	ADP
eurjchem-371	63	10	a	a	DET
eurjchem-371	63	11	weighted	weighted	ADJ
eurjchem-371	63	12	nonlinear	nonlinear	ADJ
eurjchem-371	63	13	least	least	ADJ
eurjchem-371	63	14	squares	square	NOUN
eurjchem-371	63	15	procedure	procedure	NOUN
eurjchem-371	63	16	.	.	PUNCT
eurjchem-371	64	1	the	the	DET
eurjchem-371	64	2	intercept	intercept	NOUN
eurjchem-371	64	3	parameter	parameter	NOUN
eurjchem-371	64	4	‘	'	PUNCT
eurjchem-371	64	5	α	α	NOUN
eurjchem-371	64	6	’	'	PUNCT
eurjchem-371	64	7	corresponds	correspond	NOUN
eurjchem-371	64	8	to	to	ADP
eurjchem-371	64	9	‘	'	PUNCT
eurjchem-371	64	10	–	–	PUNCT
eurjchem-371	64	11	logah+	logah+	X
eurjchem-371	64	12	’	'	PUNCT
eurjchem-371	64	13	at	at	ADP
eurjchem-371	64	14	the	the	DET
eurjchem-371	64	15	working	work	VERB
eurjchem-371	64	16	temperature	temperature	NOUN
eurjchem-371	64	17	and	and	CCONJ
eurjchem-371	64	18	ionic	ionic	ADJ
eurjchem-371	64	19	strength	strength	NOUN
eurjchem-371	64	20	.	.	PUNCT
eurjchem-371	65	1	the	the	DET
eurjchem-371	65	2	jh	jh	PROPN
eurjchem-371	65	3	term	term	NOUN
eurjchem-371	65	4	corrects	correct	VERB
eurjchem-371	65	5	ph	ph	ADJ
eurjchem-371	65	6	readings	reading	NOUN
eurjchem-371	65	7	for	for	ADP
eurjchem-371	65	8	the	the	DET
eurjchem-371	65	9	nonlinear	nonlinear	ADJ
eurjchem-371	65	10	ph	ph	ADJ
eurjchem-371	65	11	response	response	NOUN
eurjchem-371	65	12	due	due	ADP
eurjchem-371	65	13	to	to	ADP
eurjchem-371	65	14	liquid	liquid	ADJ
eurjchem-371	65	15	junction	junction	NOUN
eurjchem-371	65	16	and	and	CCONJ
eurjchem-371	65	17	asymmetry	asymmetry	NOUN
eurjchem-371	65	18	potentials	potential	NOUN
eurjchem-371	65	19	in	in	ADP
eurjchem-371	65	20	moderately	moderately	ADV
eurjchem-371	65	21	acidic	acidic	ADJ
eurjchem-371	65	22	solutions	solution	NOUN
eurjchem-371	65	23	,	,	PUNCT
eurjchem-371	65	24	while	while	SCONJ
eurjchem-371	65	25	the	the	DET
eurjchem-371	65	26	joh	joh	PROPN
eurjchem-371	65	27	term	term	NOUN
eurjchem-371	65	28	corrects	correct	NOUN
eurjchem-371	65	29	for	for	ADP
eurjchem-371	65	30	high‐ph	high‐ph	PROPN
eurjchem-371	65	31	nonlinear	nonlinear	ADJ
eurjchem-371	65	32	effect	effect	NOUN
eurjchem-371	65	33	.	.	PUNCT
eurjchem-371	66	1	factor	factor	NOUN
eurjchem-371	66	2	‘s	‘s	PART
eurjchem-371	66	3	’	'	PUNCT
eurjchem-371	66	4	accounts	account	VERB
eurjchem-371	66	5	that	that	SCONJ
eurjchem-371	66	6	a	a	DET
eurjchem-371	66	7	particular	particular	ADJ
eurjchem-371	66	8	electrode	electrode	NOUN
eurjchem-371	66	9	may	may	AUX
eurjchem-371	66	10	not	not	PART
eurjchem-371	66	11	have	have	VERB
eurjchem-371	66	12	100	100	NUM
eurjchem-371	66	13	%	%	NOUN
eurjchem-371	66	14	nernstian	nernstian	ADJ
eurjchem-371	66	15	slope	slope	NOUN
eurjchem-371	66	16	,	,	PUNCT
eurjchem-371	66	17	‘	'	PUNCT
eurjchem-371	66	18	kw	kw	X
eurjchem-371	66	19	’	'	PUNCT
eurjchem-371	66	20	is	be	AUX
eurjchem-371	66	21	the	the	DET
eurjchem-371	66	22	ionisation	ionisation	NOUN
eurjchem-371	66	23	constant	constant	ADJ
eurjchem-371	66	24	of	of	ADP
eurjchem-371	66	25	water	water	NOUN
eurjchem-371	66	26	.	.	PUNCT
eurjchem-371	67	1	these	these	DET
eurjchem-371	67	2	values	value	NOUN
eurjchem-371	67	3	were	be	AUX
eurjchem-371	67	4	obtained	obtain	VERB
eurjchem-371	67	5	from	from	ADP
eurjchem-371	67	6	three	three	NUM
eurjchem-371	67	7	parallel	parallel	ADJ
eurjchem-371	67	8	“	"	PUNCT
eurjchem-371	67	9	blank	blank	ADJ
eurjchem-371	67	10	”	"	PUNCT
eurjchem-371	67	11	titrations	titration	NOUN
eurjchem-371	67	12	.	.	PUNCT
eurjchem-371	68	1	the	the	DET
eurjchem-371	68	2	“	"	PUNCT
eurjchem-371	68	3	goodness‐of‐fit	goodness‐of‐fit	PROPN
eurjchem-371	68	4	”	"	PUNCT
eurjchem-371	68	5	(	(	PUNCT
eurjchem-371	68	6	gof	gof	ADJ
eurjchem-371	68	7	)	)	PUNCT
eurjchem-371	68	8	value	value	NOUN
eurjchem-371	68	9	of	of	ADP
eurjchem-371	68	10	less	less	ADJ
eurjchem-371	68	11	than	than	ADP
eurjchem-371	68	12	1.5	1.5	NUM
eurjchem-371	68	13	was	be	AUX
eurjchem-371	68	14	observed	observe	VERB
eurjchem-371	68	15	for	for	ADP
eurjchem-371	68	16	all	all	DET
eurjchem-371	68	17	the	the	DET
eurjchem-371	68	18	blank	blank	ADJ
eurjchem-371	68	19	titrations	titration	NOUN
eurjchem-371	68	20	,	,	PUNCT
eurjchem-371	68	21	indicating	indicate	VERB
eurjchem-371	68	22	the	the	DET
eurjchem-371	68	23	statistical	statistical	ADJ
eurjchem-371	68	24	significance	significance	NOUN
eurjchem-371	68	25	of	of	ADP
eurjchem-371	68	26	the	the	DET
eurjchem-371	68	27	data	datum	NOUN
eurjchem-371	68	28	.	.	PUNCT
eurjchem-371	69	1	these	these	DET
eurjchem-371	69	2	parameters	parameter	NOUN
eurjchem-371	69	3	were	be	AUX
eurjchem-371	69	4	used	use	VERB
eurjchem-371	69	5	to	to	PART
eurjchem-371	69	6	calculate	calculate	VERB
eurjchem-371	69	7	the	the	DET
eurjchem-371	69	8	pka	pka	NOUN
eurjchem-371	69	9	and	and	CCONJ
eurjchem-371	69	10	pska	pska	NOUN
eurjchem-371	69	11	values	value	NOUN
eurjchem-371	69	12	.	.	PUNCT
eurjchem-371	70	1	2.2	2.2	NUM
eurjchem-371	70	2	.	.	PUNCT
eurjchem-371	70	3	methods	method	NOUN
eurjchem-371	70	4	2.2.1	2.2.1	NUM
eurjchem-371	70	5	.	.	PUNCT
eurjchem-371	70	6	reagents	reagent	NOUN
eurjchem-371	70	7	the	the	DET
eurjchem-371	70	8	following	follow	VERB
eurjchem-371	70	9	drugs	drug	NOUN
eurjchem-371	70	10	viz	viz	NOUN
eurjchem-371	70	11	;	;	PUNCT
eurjchem-371	70	12	amiloride	amiloride	ADJ
eurjchem-371	70	13	hydrochloride	hydrochloride	NOUN
eurjchem-371	70	14	(	(	PUNCT
eurjchem-371	70	15	aml	aml	PROPN
eurjchem-371	70	16	)	)	PUNCT
eurjchem-371	70	17	,	,	PUNCT
eurjchem-371	70	18	propranolol	propranolol	NOUN
eurjchem-371	70	19	hydrochloride	hydrochloride	NOUN
eurjchem-371	70	20	(	(	PUNCT
eurjchem-371	70	21	pro	pro	ADJ
eurjchem-371	70	22	)	)	PUNCT
eurjchem-371	70	23	,	,	PUNCT
eurjchem-371	70	24	atenolol	atenolol	PROPN
eurjchem-371	70	25	(	(	PUNCT
eurjchem-371	70	26	atn	atn	PROPN
eurjchem-371	70	27	)	)	PUNCT
eurjchem-371	70	28	,	,	PUNCT
eurjchem-371	70	29	metoprolol	metoprolol	PROPN
eurjchem-371	70	30	tartrate	tartrate	PROPN
eurjchem-371	70	31	(	(	PUNCT
eurjchem-371	70	32	mt	mt	PROPN
eurjchem-371	70	33	)	)	PUNCT
eurjchem-371	70	34	,	,	PUNCT
eurjchem-371	70	35	amlodipine	amlodipine	NOUN
eurjchem-371	70	36	besylate	besylate	NOUN
eurjchem-371	70	37	(	(	PUNCT
eurjchem-371	70	38	ab	ab	PROPN
eurjchem-371	70	39	)	)	PUNCT
eurjchem-371	70	40	belonging	belong	VERB
eurjchem-371	70	41	to	to	ADP
eurjchem-371	70	42	betablockers	betablocker	NOUN
eurjchem-371	70	43	and	and	CCONJ
eurjchem-371	70	44	gliclazide	gliclazide	NOUN
eurjchem-371	70	45	(	(	PUNCT
eurjchem-371	70	46	glc	glc	PROPN
eurjchem-371	70	47	)	)	PUNCT
eurjchem-371	70	48	,	,	PUNCT
eurjchem-371	70	49	pioglitazone	pioglitazone	NOUN
eurjchem-371	70	50	(	(	PUNCT
eurjchem-371	70	51	pgl	pgl	NOUN
eurjchem-371	70	52	)	)	PUNCT
eurjchem-371	70	53	,	,	PUNCT
eurjchem-371	70	54	glipizide	glipizide	INTJ
eurjchem-371	70	55	(	(	PUNCT
eurjchem-371	70	56	glz	glz	NOUN
eurjchem-371	70	57	)	)	PUNCT
eurjchem-371	70	58	,	,	PUNCT
eurjchem-371	70	59	glibenclamide	glibenclamide	NOUN
eurjchem-371	70	60	(	(	PUNCT
eurjchem-371	70	61	glb	glb	NOUN
eurjchem-371	70	62	)	)	PUNCT
eurjchem-371	70	63	,	,	PUNCT
eurjchem-371	70	64	belonging	belong	VERB
eurjchem-371	70	65	to	to	ADP
eurjchem-371	70	66	anti‐diabetic	anti‐diabetic	ADJ
eurjchem-371	70	67	drugs	drug	NOUN
eurjchem-371	70	68	were	be	AUX
eurjchem-371	70	69	selected	select	VERB
eurjchem-371	70	70	for	for	ADP
eurjchem-371	70	71	the	the	DET
eurjchem-371	70	72	present	present	ADJ
eurjchem-371	70	73	investigation	investigation	NOUN
eurjchem-371	70	74	.	.	PUNCT
eurjchem-371	71	1	pro	pro	ADJ
eurjchem-371	71	2	,	,	PUNCT
eurjchem-371	71	3	atn	atn	PROPN
eurjchem-371	71	4	,	,	PUNCT
eurjchem-371	71	5	mt	mt	PROPN
eurjchem-371	71	6	,	,	PUNCT
eurjchem-371	71	7	ab	ab	PROPN
eurjchem-371	71	8	,	,	PUNCT
eurjchem-371	71	9	and	and	CCONJ
eurjchem-371	71	10	pgl	pgl	NOUN
eurjchem-371	71	11	were	be	AUX
eurjchem-371	71	12	obtained	obtain	VERB
eurjchem-371	71	13	from	from	ADP
eurjchem-371	71	14	ipca	ipca	PROPN
eurjchem-371	71	15	laboratories	laboratory	NOUN
eurjchem-371	71	16	limited	limit	VERB
eurjchem-371	71	17	,	,	PUNCT
eurjchem-371	71	18	mumbai	mumbai	PROPN
eurjchem-371	71	19	;	;	PUNCT
eurjchem-371	71	20	aml	aml	PROPN
eurjchem-371	71	21	,	,	PUNCT
eurjchem-371	71	22	glc	glc	PROPN
eurjchem-371	71	23	and	and	CCONJ
eurjchem-371	71	24	glz	glz	PROPN
eurjchem-371	71	25	were	be	AUX
eurjchem-371	71	26	obtained	obtain	VERB
eurjchem-371	71	27	as	as	ADP
eurjchem-371	71	28	gift	gift	NOUN
eurjchem-371	71	29	samples	sample	NOUN
eurjchem-371	71	30	from	from	ADP
eurjchem-371	71	31	bal	bal	PROPN
eurjchem-371	71	32	pharma	pharma	PROPN
eurjchem-371	71	33	limited	limit	VERB
eurjchem-371	71	34	,	,	PUNCT
eurjchem-371	71	35	bangalore	bangalore	NOUN
eurjchem-371	71	36	.	.	PUNCT
eurjchem-371	72	1	glb	glb	PROPN
eurjchem-371	72	2	was	be	AUX
eurjchem-371	72	3	obtained	obtain	VERB
eurjchem-371	72	4	from	from	ADP
eurjchem-371	72	5	sigma	sigma	PROPN
eurjchem-371	72	6	.	.	PUNCT
eurjchem-371	73	1	all	all	DET
eurjchem-371	73	2	the	the	DET
eurjchem-371	73	3	drug	drug	NOUN
eurjchem-371	73	4	compounds	compound	NOUN
eurjchem-371	73	5	used	use	VERB
eurjchem-371	73	6	were	be	AUX
eurjchem-371	73	7	of	of	ADP
eurjchem-371	73	8	pharmaceutical	pharmaceutical	ADJ
eurjchem-371	73	9	grade	grade	NOUN
eurjchem-371	73	10	.	.	PUNCT
eurjchem-371	74	1	of	of	ADP
eurjchem-371	74	2	the	the	DET
eurjchem-371	74	3	chemicals	chemical	NOUN
eurjchem-371	74	4	used	use	VERB
eurjchem-371	74	5	for	for	ADP
eurjchem-371	74	6	pka	pka	PROPN
eurjchem-371	74	7	determination	determination	NOUN
eurjchem-371	74	8	,	,	PUNCT
eurjchem-371	74	9	methanol	methanol	NOUN
eurjchem-371	74	10	,	,	PUNCT
eurjchem-371	74	11	ethanol	ethanol	NOUN
eurjchem-371	74	12	,	,	PUNCT
eurjchem-371	74	13	1,4‐dioxane	1,4‐dioxane	NUM
eurjchem-371	74	14	and	and	CCONJ
eurjchem-371	74	15	acetonitrile	acetonitrile	NOUN
eurjchem-371	74	16	were	be	AUX
eurjchem-371	74	17	of	of	ADP
eurjchem-371	74	18	hplc	hplc	NOUN
eurjchem-371	74	19	grade	grade	NOUN
eurjchem-371	74	20	from	from	ADP
eurjchem-371	74	21	merck	merck	PROPN
eurjchem-371	74	22	.	.	PUNCT
eurjchem-371	75	1	solutions	solution	NOUN
eurjchem-371	75	2	and	and	CCONJ
eurjchem-371	75	3	solvent	solvent	NOUN
eurjchem-371	75	4	mixtures	mixture	NOUN
eurjchem-371	75	5	were	be	AUX
eurjchem-371	75	6	made	make	VERB
eurjchem-371	75	7	up	up	ADP
eurjchem-371	75	8	of	of	ADP
eurjchem-371	75	9	distilled	distil	VERB
eurjchem-371	75	10	water	water	NOUN
eurjchem-371	75	11	obtained	obtain	VERB
eurjchem-371	75	12	from	from	ADP
eurjchem-371	75	13	millipore	millipore	PROPN
eurjchem-371	75	14	,	,	PUNCT
eurjchem-371	75	15	milli‐q	milli‐q	PROPN
eurjchem-371	75	16	(	(	PUNCT
eurjchem-371	75	17	bedford	bedford	PROPN
eurjchem-371	75	18	,	,	PUNCT
eurjchem-371	75	19	ma	ma	PROPN
eurjchem-371	75	20	,	,	PUNCT
eurjchem-371	75	21	usa	usa	PROPN
eurjchem-371	75	22	)	)	PUNCT
eurjchem-371	75	23	purification	purification	NOUN
eurjchem-371	75	24	system	system	NOUN
eurjchem-371	75	25	.	.	PUNCT
eurjchem-371	76	1	readymade	readymade	NOUN
eurjchem-371	76	2	0.5	0.5	NUM
eurjchem-371	76	3	m	m	PROPN
eurjchem-371	76	4	solutions	solution	NOUN
eurjchem-371	76	5	of	of	ADP
eurjchem-371	76	6	potassium	potassium	NOUN
eurjchem-371	76	7	hydroxide	hydroxide	NOUN
eurjchem-371	76	8	and	and	CCONJ
eurjchem-371	76	9	hydrochloric	hydrochloric	ADJ
eurjchem-371	76	10	acid	acid	NOUN
eurjchem-371	76	11	were	be	AUX
eurjchem-371	76	12	obtained	obtain	VERB
eurjchem-371	76	13	from	from	ADP
eurjchem-371	76	14	merck	merck	PROPN
eurjchem-371	76	15	.	.	PUNCT
eurjchem-371	77	1	potassium	potassium	NOUN
eurjchem-371	77	2	hydroxide	hydroxide	NOUN
eurjchem-371	77	3	is	be	AUX
eurjchem-371	77	4	standardized	standardize	VERB
eurjchem-371	77	5	against	against	ADP
eurjchem-371	77	6	primary	primary	ADJ
eurjchem-371	77	7	standard	standard	NOUN
eurjchem-371	77	8	using	use	VERB
eurjchem-371	77	9	potassium	potassium	NOUN
eurjchem-371	77	10	hydrogen	hydrogen	NOUN
eurjchem-371	77	11	phthalate	phthalate	NOUN
eurjchem-371	77	12	.	.	PUNCT
eurjchem-371	78	1	potassium	potassium	NOUN
eurjchem-371	78	2	hydrogen	hydrogen	NOUN
eurjchem-371	78	3	phthalate	phthalate	NOUN
eurjchem-371	78	4	is	be	AUX
eurjchem-371	78	5	purchased	purchase	VERB
eurjchem-371	78	6	from	from	ADP
eurjchem-371	78	7	sigma	sigma	PROPN
eurjchem-371	78	8	.	.	PUNCT
eurjchem-371	79	1	di‐	di‐	NOUN
eurjchem-371	79	2	potassium	potassium	NOUN
eurjchem-371	79	3	hydrogen	hydrogen	NOUN
eurjchem-371	79	4	phosphate	phosphate	NOUN
eurjchem-371	79	5	and	and	CCONJ
eurjchem-371	79	6	potassium	potassium	NOUN
eurjchem-371	79	7	chloride	chloride	NOUN
eurjchem-371	79	8	were	be	AUX
eurjchem-371	79	9	of	of	ADP
eurjchem-371	79	10	analytical	analytical	ADJ
eurjchem-371	79	11	grade	grade	NOUN
eurjchem-371	79	12	from	from	ADP
eurjchem-371	79	13	sigma	sigma	PROPN
eurjchem-371	79	14	.	.	PUNCT
eurjchem-371	80	1	standards	standard	NOUN
eurjchem-371	80	2	for	for	ADP
eurjchem-371	80	3	hplc	hplc	NOUN
eurjchem-371	80	4	log	log	NOUN
eurjchem-371	80	5	p	p	NOUN
eurjchem-371	80	6	measurements	measurement	NOUN
eurjchem-371	80	7	were	be	AUX
eurjchem-371	80	8	procured	procure	VERB
eurjchem-371	80	9	from	from	ADP
eurjchem-371	80	10	sigma	sigma	PROPN
eurjchem-371	80	11	.	.	PUNCT
eurjchem-371	81	1	2.2.2	2.2.2	NUM
eurjchem-371	81	2	.	.	PUNCT
eurjchem-371	82	1	preparation	preparation	NOUN
eurjchem-371	82	2	of	of	ADP
eurjchem-371	82	3	co‐solvent	co‐solvent	ADJ
eurjchem-371	82	4	mixtures	mixture	NOUN
eurjchem-371	82	5	for	for	ADP
eurjchem-371	82	6	pska	pska	NOUN
eurjchem-371	82	7	determination	determination	NOUN
eurjchem-371	82	8	of	of	ADP
eurjchem-371	82	9	selected	select	VERB
eurjchem-371	82	10	drugs	drug	NOUN
eurjchem-371	82	11	,	,	PUNCT
eurjchem-371	82	12	a	a	DET
eurjchem-371	82	13	80	80	NUM
eurjchem-371	82	14	%	%	NOUN
eurjchem-371	82	15	(	(	PUNCT
eurjchem-371	82	16	v	v	NOUN
eurjchem-371	82	17	/	/	SYM
eurjchem-371	82	18	v	v	NOUN
eurjchem-371	82	19	)	)	PUNCT
eurjchem-371	82	20	methanol	methanol	NOUN
eurjchem-371	82	21	,	,	PUNCT
eurjchem-371	82	22	60	60	NUM
eurjchem-371	82	23	%	%	NOUN
eurjchem-371	82	24	(	(	PUNCT
eurjchem-371	82	25	v	v	NOUN
eurjchem-371	82	26	/	/	SYM
eurjchem-371	82	27	v	v	NOUN
eurjchem-371	82	28	)	)	PUNCT
eurjchem-371	82	29	ethanol	ethanol	NOUN
eurjchem-371	82	30	,	,	PUNCT
eurjchem-371	82	31	1,4‐dioxane	1,4‐dioxane	NUM
eurjchem-371	82	32	and	and	CCONJ
eurjchem-371	82	33	50	50	NUM
eurjchem-371	82	34	%	%	NOUN
eurjchem-371	82	35	(	(	PUNCT
eurjchem-371	82	36	v	v	NOUN
eurjchem-371	82	37	/	/	SYM
eurjchem-371	82	38	v	v	NOUN
eurjchem-371	82	39	)	)	PUNCT
eurjchem-371	82	40	of	of	ADP
eurjchem-371	82	41	acetonitrile	acetonitrile	NOUN
eurjchem-371	82	42	in	in	ADP
eurjchem-371	82	43	0.15	0.15	NUM
eurjchem-371	82	44	m	m	NOUN
eurjchem-371	82	45	kcl	kcl	PROPN
eurjchem-371	82	46	adjusted	adjust	VERB
eurjchem-371	82	47	water	water	NOUN
eurjchem-371	82	48	is	be	AUX
eurjchem-371	82	49	prepared	prepare	VERB
eurjchem-371	82	50	and	and	CCONJ
eurjchem-371	82	51	used	use	VERB
eurjchem-371	82	52	throughout	throughout	ADP
eurjchem-371	82	53	our	our	PRON
eurjchem-371	82	54	investigation	investigation	NOUN
eurjchem-371	82	55	.	.	PUNCT
eurjchem-371	83	1	2.2.3	2.2.3	X
eurjchem-371	83	2	.	.	PUNCT
eurjchem-371	83	3	titration	titration	NOUN
eurjchem-371	83	4	in	in	ADP
eurjchem-371	83	5	aqueous	aqueous	ADJ
eurjchem-371	83	6	medium	medium	NOUN
eurjchem-371	83	7	for	for	ADP
eurjchem-371	83	8	bases	basis	NOUN
eurjchem-371	83	9	,	,	PUNCT
eurjchem-371	83	10	in	in	ADP
eurjchem-371	83	11	each	each	DET
eurjchem-371	83	12	experiment	experiment	NOUN
eurjchem-371	83	13	,	,	PUNCT
eurjchem-371	83	14	about	about	ADV
eurjchem-371	83	15	2	2	NUM
eurjchem-371	83	16	mg	mg	NOUN
eurjchem-371	83	17	of	of	ADP
eurjchem-371	83	18	sample	sample	NOUN
eurjchem-371	83	19	,	,	PUNCT
eurjchem-371	83	20	containing	contain	VERB
eurjchem-371	83	21	10	10	NUM
eurjchem-371	83	22	ml	ml	NOUN
eurjchem-371	83	23	of	of	ADP
eurjchem-371	83	24	0.15	0.15	NUM
eurjchem-371	83	25	m	m	NOUN
eurjchem-371	83	26	ionic	ionic	ADJ
eurjchem-371	83	27	strength	strength	NOUN
eurjchem-371	83	28	water	water	NOUN
eurjchem-371	83	29	,	,	PUNCT
eurjchem-371	83	30	was	be	AUX
eurjchem-371	83	31	pre	pre	AUX
eurjchem-371	83	32	acidified	acidify	VERB
eurjchem-371	83	33	to	to	ADP
eurjchem-371	83	34	ph	ph	PROPN
eurjchem-371	83	35	1.8–2.0	1.8–2.0	NUM
eurjchem-371	83	36	with	with	ADP
eurjchem-371	83	37	0.5	0.5	NUM
eurjchem-371	83	38	m	m	NOUN
eurjchem-371	83	39	hcl	hcl	PROPN
eurjchem-371	83	40	and	and	CCONJ
eurjchem-371	83	41	then	then	ADV
eurjchem-371	83	42	titrated	titrate	VERB
eurjchem-371	83	43	with	with	ADP
eurjchem-371	83	44	0.5	0.5	NUM
eurjchem-371	83	45	m	m	NOUN
eurjchem-371	83	46	koh	koh	NOUN
eurjchem-371	83	47	to	to	ADP
eurjchem-371	83	48	an	an	DET
eurjchem-371	83	49	appropriately	appropriately	ADV
eurjchem-371	83	50	high	high	ADJ
eurjchem-371	83	51	ph	ph	VERB
eurjchem-371	83	52	,	,	PUNCT
eurjchem-371	83	53	usually	usually	ADV
eurjchem-371	83	54	12	12	NUM
eurjchem-371	83	55	.	.	PUNCT
eurjchem-371	84	1	in	in	ADP
eurjchem-371	84	2	the	the	DET
eurjchem-371	84	3	case	case	NOUN
eurjchem-371	84	4	of	of	ADP
eurjchem-371	84	5	acids	acid	NOUN
eurjchem-371	84	6	,	,	PUNCT
eurjchem-371	84	7	the	the	DET
eurjchem-371	84	8	titration	titration	NOUN
eurjchem-371	84	9	was	be	AUX
eurjchem-371	84	10	performed	perform	VERB
eurjchem-371	84	11	in	in	ADP
eurjchem-371	84	12	the	the	DET
eurjchem-371	84	13	opposite	opposite	ADJ
eurjchem-371	84	14	direction	direction	NOUN
eurjchem-371	84	15	.	.	PUNCT
eurjchem-371	85	1	38	38	NUM
eurjchem-371	85	2	narasimham	narasimham	PROPN
eurjchem-371	85	3	and	and	CCONJ
eurjchem-371	85	4	barhate	barhate	VERB
eurjchem-371	85	5	/	/	SYM
eurjchem-371	85	6	european	european	ADJ
eurjchem-371	85	7	journal	journal	PROPN
eurjchem-371	85	8	of	of	ADP
eurjchem-371	85	9	chemistry	chemistry	NOUN
eurjchem-371	85	10	2	2	NUM
eurjchem-371	85	11	(	(	PUNCT
eurjchem-371	85	12	1	1	NUM
eurjchem-371	85	13	)	)	PUNCT
eurjchem-371	85	14	(	(	PUNCT
eurjchem-371	85	15	2011	2011	NUM
eurjchem-371	85	16	)	)	PUNCT
eurjchem-371	85	17	36‐46	36‐46	NOUN
eurjchem-371	85	18	the	the	DET
eurjchem-371	85	19	titrations	titration	NOUN
eurjchem-371	85	20	were	be	AUX
eurjchem-371	85	21	performed	perform	VERB
eurjchem-371	85	22	at	at	ADP
eurjchem-371	85	23	25.0	25.0	NUM
eurjchem-371	85	24	±	±	NUM
eurjchem-371	85	25	0.5	0.5	NUM
eurjchem-371	85	26	°	°	ADP
eurjchem-371	85	27	c	c	NOUN
eurjchem-371	85	28	,	,	PUNCT
eurjchem-371	85	29	under	under	ADP
eurjchem-371	85	30	argon	argon	NOUN
eurjchem-371	85	31	atmosphere	atmosphere	NOUN
eurjchem-371	85	32	,	,	PUNCT
eurjchem-371	85	33	at	at	ADP
eurjchem-371	85	34	i	i	X
eurjchem-371	85	35	=	=	PUNCT
eurjchem-371	85	36	0.15	0.15	NUM
eurjchem-371	85	37	m	m	NOUN
eurjchem-371	85	38	ionic	ionic	ADJ
eurjchem-371	85	39	strength	strength	NOUN
eurjchem-371	85	40	using	use	VERB
eurjchem-371	85	41	kcl	kcl	PROPN
eurjchem-371	85	42	.	.	PUNCT
eurjchem-371	86	1	a	a	DET
eurjchem-371	86	2	minimum	minimum	NOUN
eurjchem-371	86	3	of	of	ADP
eurjchem-371	86	4	three	three	NUM
eurjchem-371	86	5	parallel	parallel	ADJ
eurjchem-371	86	6	measurements	measurement	NOUN
eurjchem-371	86	7	were	be	AUX
eurjchem-371	86	8	carried	carry	VERB
eurjchem-371	86	9	out	out	ADP
eurjchem-371	86	10	and	and	CCONJ
eurjchem-371	86	11	the	the	DET
eurjchem-371	86	12	pka	pka	PROPN
eurjchem-371	86	13	values	value	NOUN
eurjchem-371	86	14	of	of	ADP
eurjchem-371	86	15	samples	sample	NOUN
eurjchem-371	86	16	were	be	AUX
eurjchem-371	86	17	calculated	calculate	VERB
eurjchem-371	86	18	using	use	VERB
eurjchem-371	86	19	refinementprotm	refinementprotm	ADJ
eurjchem-371	86	20	software	software	NOUN
eurjchem-371	86	21	.	.	PUNCT
eurjchem-371	87	1	2.2.4	2.2.4	NUM
eurjchem-371	87	2	.	.	X
eurjchem-371	87	3	titration	titration	NOUN
eurjchem-371	87	4	in	in	ADP
eurjchem-371	87	5	co	co	NOUN
eurjchem-371	87	6	solvent	solvent	ADJ
eurjchem-371	87	7	–	–	PUNCT
eurjchem-371	87	8	water	water	NOUN
eurjchem-371	87	9	mixtures	mixture	NOUN
eurjchem-371	87	10	about	about	ADV
eurjchem-371	87	11	2	2	NUM
eurjchem-371	87	12	mg	mg	NOUN
eurjchem-371	87	13	each	each	PRON
eurjchem-371	87	14	of	of	ADP
eurjchem-371	87	15	selected	select	VERB
eurjchem-371	87	16	drug	drug	NOUN
eurjchem-371	87	17	compound	compound	NOUN
eurjchem-371	87	18	,	,	PUNCT
eurjchem-371	87	19	containing	contain	VERB
eurjchem-371	87	20	6‐	6‐	PRON
eurjchem-371	87	21	10	10	NUM
eurjchem-371	87	22	ml	ml	NOUN
eurjchem-371	87	23	of	of	ADP
eurjchem-371	87	24	0.15	0.15	NUM
eurjchem-371	87	25	m	m	PROPN
eurjchem-371	87	26	semi‐aqueous	semi‐aqueous	ADJ
eurjchem-371	87	27	solutions	solution	NOUN
eurjchem-371	87	28	,	,	PUNCT
eurjchem-371	87	29	was	be	AUX
eurjchem-371	87	30	titrated	titrate	VERB
eurjchem-371	87	31	under	under	ADP
eurjchem-371	87	32	the	the	DET
eurjchem-371	87	33	same	same	ADJ
eurjchem-371	87	34	conditions	condition	NOUN
eurjchem-371	87	35	as	as	ADP
eurjchem-371	87	36	in	in	ADP
eurjchem-371	87	37	aqueous	aqueous	ADJ
eurjchem-371	87	38	titration	titration	NOUN
eurjchem-371	87	39	(	(	PUNCT
eurjchem-371	87	40	section	section	NOUN
eurjchem-371	87	41	2.2.3	2.2.3	NUM
eurjchem-371	87	42	)	)	PUNCT
eurjchem-371	87	43	but	but	CCONJ
eurjchem-371	87	44	in	in	ADP
eurjchem-371	87	45	the	the	DET
eurjchem-371	87	46	presence	presence	NOUN
eurjchem-371	87	47	of	of	ADP
eurjchem-371	87	48	co‐solvents	co‐solvent	NOUN
eurjchem-371	87	49	containing	contain	VERB
eurjchem-371	87	50	6	6	NUM
eurjchem-371	87	51	and	and	CCONJ
eurjchem-371	87	52	60	60	NUM
eurjchem-371	87	53	wt%	wt%	ADJ
eurjchem-371	87	54	of	of	ADP
eurjchem-371	87	55	methanol	methanol	NOUN
eurjchem-371	87	56	,	,	PUNCT
eurjchem-371	87	57	ethanol	ethanol	NOUN
eurjchem-371	87	58	,	,	PUNCT
eurjchem-371	87	59	acetonitrile	acetonitrile	NOUN
eurjchem-371	87	60	and	and	CCONJ
eurjchem-371	87	61	1,4‐dioxane	1,4‐dioxane	NUM
eurjchem-371	87	62	.	.	PUNCT
eurjchem-371	88	1	each	each	DET
eurjchem-371	88	2	sample	sample	NOUN
eurjchem-371	88	3	was	be	AUX
eurjchem-371	88	4	measured	measure	VERB
eurjchem-371	88	5	in	in	ADP
eurjchem-371	88	6	all	all	DET
eurjchem-371	88	7	the	the	DET
eurjchem-371	88	8	four	four	NUM
eurjchem-371	88	9	selected	select	VERB
eurjchem-371	88	10	co‐solvents	co‐solvent	NOUN
eurjchem-371	88	11	inde‐	inde‐	ADP
eurjchem-371	88	12	pendently	pendently	ADV
eurjchem-371	88	13	.	.	PUNCT
eurjchem-371	89	1	at	at	ADP
eurjchem-371	89	2	each	each	DET
eurjchem-371	89	3	selected	select	VERB
eurjchem-371	89	4	co‐solvent	co‐solvent	ADJ
eurjchem-371	89	5	mixture	mixture	NOUN
eurjchem-371	89	6	,	,	PUNCT
eurjchem-371	89	7	measurements	measurement	NOUN
eurjchem-371	89	8	were	be	AUX
eurjchem-371	89	9	carried	carry	VERB
eurjchem-371	89	10	out	out	ADP
eurjchem-371	89	11	in	in	ADP
eurjchem-371	89	12	at	at	ADP
eurjchem-371	89	13	least	least	ADJ
eurjchem-371	89	14	in	in	ADP
eurjchem-371	89	15	three	three	NUM
eurjchem-371	89	16	different	different	ADJ
eurjchem-371	89	17	wt%	wt%	ADJ
eurjchem-371	89	18	at	at	ADP
eurjchem-371	89	19	constant	constant	ADJ
eurjchem-371	89	20	ionic	ionic	ADJ
eurjchem-371	89	21	strength	strength	NOUN
eurjchem-371	89	22	(	(	PUNCT
eurjchem-371	89	23	i	i	NOUN
eurjchem-371	89	24	=	=	NOUN
eurjchem-371	89	25	0.15	0.15	NUM
eurjchem-371	89	26	m	m	AUX
eurjchem-371	89	27	using	use	VERB
eurjchem-371	89	28	kcl	kcl	NOUN
eurjchem-371	89	29	)	)	PUNCT
eurjchem-371	89	30	and	and	CCONJ
eurjchem-371	89	31	temperature	temperature	NOUN
eurjchem-371	89	32	(	(	PUNCT
eurjchem-371	89	33	25.0±0.5	25.0±0.5	NUM
eurjchem-371	89	34	°	°	NOUN
eurjchem-371	89	35	c	c	NOUN
eurjchem-371	89	36	)	)	PUNCT
eurjchem-371	89	37	under	under	ADP
eurjchem-371	89	38	argon	argon	NOUN
eurjchem-371	89	39	atmosphere	atmosphere	NOUN
eurjchem-371	89	40	.	.	PUNCT
eurjchem-371	90	1	the	the	DET
eurjchem-371	90	2	effect	effect	NOUN
eurjchem-371	90	3	of	of	ADP
eurjchem-371	90	4	ionic	ionic	ADJ
eurjchem-371	90	5	strength	strength	NOUN
eurjchem-371	90	6	(	(	PUNCT
eurjchem-371	90	7	i	i	NOUN
eurjchem-371	90	8	=	=	PUNCT
eurjchem-371	90	9	0.15	0.15	NUM
eurjchem-371	90	10	m	m	PROPN
eurjchem-371	90	11	,	,	PUNCT
eurjchem-371	90	12	0.3	0.3	NUM
eurjchem-371	90	13	m	m	NOUN
eurjchem-371	90	14	and	and	CCONJ
eurjchem-371	90	15	0.5	0.5	NUM
eurjchem-371	90	16	m	m	VERB
eurjchem-371	90	17	using	use	VERB
eurjchem-371	90	18	kcl	kcl	NOUN
eurjchem-371	90	19	)	)	PUNCT
eurjchem-371	90	20	at	at	ADP
eurjchem-371	90	21	constant	constant	ADJ
eurjchem-371	90	22	temperature	temperature	NOUN
eurjchem-371	90	23	(	(	PUNCT
eurjchem-371	90	24	25.0±0.5	25.0±0.5	NUM
eurjchem-371	90	25	°	°	NOUN
eurjchem-371	90	26	c	c	NOUN
eurjchem-371	90	27	)	)	PUNCT
eurjchem-371	90	28	and	and	CCONJ
eurjchem-371	90	29	the	the	DET
eurjchem-371	90	30	effect	effect	NOUN
eurjchem-371	90	31	of	of	ADP
eurjchem-371	90	32	temperature	temperature	NOUN
eurjchem-371	90	33	(	(	PUNCT
eurjchem-371	90	34	25	25	NUM
eurjchem-371	90	35	,	,	PUNCT
eurjchem-371	90	36	35	35	NUM
eurjchem-371	90	37	and	and	CCONJ
eurjchem-371	90	38	45	45	NUM
eurjchem-371	90	39	°	°	NOUN
eurjchem-371	90	40	c	c	NOUN
eurjchem-371	90	41	)	)	PUNCT
eurjchem-371	90	42	at	at	ADP
eurjchem-371	90	43	constant	constant	ADJ
eurjchem-371	90	44	ionic	ionic	ADJ
eurjchem-371	90	45	strength	strength	NOUN
eurjchem-371	90	46	(	(	PUNCT
eurjchem-371	90	47	i	i	NOUN
eurjchem-371	90	48	=	=	NOUN
eurjchem-371	90	49	0.15	0.15	NUM
eurjchem-371	90	50	m	m	NOUN
eurjchem-371	90	51	kcl	kcl	NOUN
eurjchem-371	90	52	)	)	PUNCT
eurjchem-371	90	53	using	use	VERB
eurjchem-371	90	54	methanol	methanol	NOUN
eurjchem-371	90	55	as	as	SCONJ
eurjchem-371	90	56	co	co	NOUN
eurjchem-371	90	57	solvent	solvent	PROPN
eurjchem-371	90	58	were	be	AUX
eurjchem-371	90	59	carried	carry	VERB
eurjchem-371	90	60	out	out	ADP
eurjchem-371	90	61	under	under	ADP
eurjchem-371	90	62	argon	argon	NOUN
eurjchem-371	90	63	atmosphere	atmosphere	NOUN
eurjchem-371	90	64	.	.	PUNCT
eurjchem-371	91	1	the	the	DET
eurjchem-371	91	2	apparent	apparent	ADJ
eurjchem-371	91	3	ionization	ionization	NOUN
eurjchem-371	91	4	constants	constant	NOUN
eurjchem-371	91	5	in	in	ADP
eurjchem-371	91	6	the	the	DET
eurjchem-371	91	7	mixed	mixed	ADJ
eurjchem-371	91	8	solvent	solvent	NOUN
eurjchem-371	91	9	(	(	PUNCT
eurjchem-371	91	10	pska	pska	NOUN
eurjchem-371	91	11	)	)	PUNCT
eurjchem-371	91	12	were	be	AUX
eurjchem-371	91	13	calculated	calculate	VERB
eurjchem-371	91	14	from	from	ADP
eurjchem-371	91	15	the	the	DET
eurjchem-371	91	16	difference	difference	NOUN
eurjchem-371	91	17	(	(	PUNCT
eurjchem-371	91	18	bjerrum	bjerrum	NOUN
eurjchem-371	91	19	)	)	PUNCT
eurjchem-371	91	20	plot	plot	NOUN
eurjchem-371	91	21	.	.	PUNCT
eurjchem-371	92	1	the	the	DET
eurjchem-371	92	2	results	result	NOUN
eurjchem-371	92	3	obtained	obtain	VERB
eurjchem-371	92	4	through	through	ADP
eurjchem-371	92	5	this	this	DET
eurjchem-371	92	6	difference	difference	NOUN
eurjchem-371	92	7	plot	plot	NOUN
eurjchem-371	92	8	is	be	AUX
eurjchem-371	92	9	often	often	ADV
eurjchem-371	92	10	found	find	VERB
eurjchem-371	92	11	suitable	suitable	ADJ
eurjchem-371	92	12	for	for	ADP
eurjchem-371	92	13	detecting	detect	VERB
eurjchem-371	92	14	small	small	ADJ
eurjchem-371	92	15	errors	error	NOUN
eurjchem-371	92	16	in	in	ADP
eurjchem-371	92	17	titration	titration	NOUN
eurjchem-371	92	18	such	such	ADJ
eurjchem-371	92	19	as	as	ADP
eurjchem-371	92	20	acidity	acidity	NOUN
eurjchem-371	92	21	error	error	NOUN
eurjchem-371	92	22	,	,	PUNCT
eurjchem-371	92	23	concentration	concentration	NOUN
eurjchem-371	92	24	error	error	NOUN
eurjchem-371	92	25	and	and	CCONJ
eurjchem-371	92	26	corrections	correction	NOUN
eurjchem-371	92	27	to	to	ADP
eurjchem-371	92	28	these	these	DET
eurjchem-371	92	29	errors	error	NOUN
eurjchem-371	92	30	has	have	AUX
eurjchem-371	92	31	become	become	VERB
eurjchem-371	92	32	necessary	necessary	ADJ
eurjchem-371	92	33	to	to	PART
eurjchem-371	92	34	achieve	achieve	VERB
eurjchem-371	92	35	the	the	DET
eurjchem-371	92	36	best	good	ADJ
eurjchem-371	92	37	fit	fit	ADJ
eurjchem-371	92	38	.	.	PUNCT
eurjchem-371	93	1	difference	difference	NOUN
eurjchem-371	93	2	plots	plot	NOUN
eurjchem-371	93	3	allow	allow	VERB
eurjchem-371	93	4	the	the	DET
eurjchem-371	93	5	pka	pka	PROPN
eurjchem-371	93	6	values	value	NOUN
eurjchem-371	93	7	of	of	ADP
eurjchem-371	93	8	monoprotic	monoprotic	ADJ
eurjchem-371	93	9	and	and	CCONJ
eurjchem-371	93	10	multiprotic	multiprotic	ADJ
eurjchem-371	93	11	weak	weak	ADJ
eurjchem-371	93	12	acids	acid	NOUN
eurjchem-371	93	13	to	to	PART
eurjchem-371	93	14	be	be	AUX
eurjchem-371	93	15	determined	determine	VERB
eurjchem-371	93	16	rapidly	rapidly	ADV
eurjchem-371	93	17	and	and	CCONJ
eurjchem-371	93	18	with	with	ADP
eurjchem-371	93	19	good	good	ADJ
eurjchem-371	93	20	precision	precision	NOUN
eurjchem-371	93	21	[	[	X
eurjchem-371	93	22	24‐25	24‐25	NUM
eurjchem-371	93	23	]	]	PUNCT
eurjchem-371	93	24	.	.	PUNCT
eurjchem-371	94	1	to	to	PART
eurjchem-371	94	2	obtain	obtain	VERB
eurjchem-371	94	3	the	the	DET
eurjchem-371	94	4	best	good	ADJ
eurjchem-371	94	5	aqueous	aqueous	ADJ
eurjchem-371	94	6	pka	pka	NOUN
eurjchem-371	94	7	value	value	NOUN
eurjchem-371	94	8	from	from	ADP
eurjchem-371	94	9	pska	pska	NOUN
eurjchem-371	94	10	data	datum	NOUN
eurjchem-371	94	11	the	the	DET
eurjchem-371	94	12	yasuda‐	yasuda‐	NOUN
eurjchem-371	94	13	shedlovsky	shedlovsky	NOUN
eurjchem-371	94	14	(	(	PUNCT
eurjchem-371	94	15	ys	ys	NOUN
eurjchem-371	94	16	)	)	PUNCT
eurjchem-371	94	17	procedure	procedure	NOUN
eurjchem-371	94	18	was	be	AUX
eurjchem-371	94	19	applied	apply	VERB
eurjchem-371	94	20	to	to	PART
eurjchem-371	94	21	estimate	estimate	VERB
eurjchem-371	94	22	the	the	DET
eurjchem-371	94	23	aqueous	aqueous	ADJ
eurjchem-371	94	24	pka	pka	NOUN
eurjchem-371	94	25	value	value	NOUN
eurjchem-371	94	26	.	.	PUNCT
eurjchem-371	95	1	the	the	DET
eurjchem-371	95	2	following	follow	VERB
eurjchem-371	95	3	equation	equation	NOUN
eurjchem-371	95	4	has	have	AUX
eurjchem-371	95	5	been	be	AUX
eurjchem-371	95	6	adopted	adopt	VERB
eurjchem-371	95	7	.	.	PUNCT
eurjchem-371	96	1	p	p	X
eurjchem-371	96	2	a	a	DET
eurjchem-371	96	3	log	log	NOUN
eurjchem-371	96	4	h2o	h2o	PROPN
eurjchem-371	96	5	(	(	PUNCT
eurjchem-371	96	6	2	2	NUM
eurjchem-371	96	7	)	)	PUNCT
eurjchem-371	96	8	where	where	SCONJ
eurjchem-371	96	9	log	log	NOUN
eurjchem-371	96	10	[	[	X
eurjchem-371	96	11	h2o	h2o	X
eurjchem-371	96	12	]	]	PUNCT
eurjchem-371	96	13	is	be	AUX
eurjchem-371	96	14	the	the	DET
eurjchem-371	96	15	molar	molar	ADJ
eurjchem-371	96	16	water	water	NOUN
eurjchem-371	96	17	concentration	concentration	NOUN
eurjchem-371	96	18	of	of	ADP
eurjchem-371	96	19	the	the	DET
eurjchem-371	96	20	given	give	VERB
eurjchem-371	96	21	solvent	solvent	NOUN
eurjchem-371	96	22	mixture	mixture	NOUN
eurjchem-371	96	23	,	,	PUNCT
eurjchem-371	96	24	‘	'	PUNCT
eurjchem-371	96	25	ε	ε	X
eurjchem-371	96	26	’	'	PUNCT
eurjchem-371	96	27	is	be	AUX
eurjchem-371	96	28	the	the	DET
eurjchem-371	96	29	dielectric	dielectric	ADJ
eurjchem-371	96	30	constant	constant	ADJ
eurjchem-371	96	31	of	of	ADP
eurjchem-371	96	32	the	the	DET
eurjchem-371	96	33	mixture	mixture	NOUN
eurjchem-371	96	34	and	and	CCONJ
eurjchem-371	96	35	‘	'	PUNCT
eurjchem-371	96	36	a	a	PRON
eurjchem-371	96	37	’	'	PUNCT
eurjchem-371	96	38	and	and	CCONJ
eurjchem-371	96	39	‘	'	PUNCT
eurjchem-371	96	40	b	b	X
eurjchem-371	96	41	’	'	PUNCT
eurjchem-371	96	42	are	be	AUX
eurjchem-371	96	43	the	the	DET
eurjchem-371	96	44	slope	slope	NOUN
eurjchem-371	96	45	and	and	CCONJ
eurjchem-371	96	46	intercept	intercept	NOUN
eurjchem-371	96	47	,	,	PUNCT
eurjchem-371	96	48	respectively	respectively	ADV
eurjchem-371	96	49	.	.	PUNCT
eurjchem-371	97	1	this	this	DET
eurjchem-371	97	2	method	method	NOUN
eurjchem-371	97	3	is	be	AUX
eurjchem-371	97	4	the	the	DET
eurjchem-371	97	5	most	most	ADV
eurjchem-371	97	6	widely	widely	ADV
eurjchem-371	97	7	used	use	VERB
eurjchem-371	97	8	procedure	procedure	NOUN
eurjchem-371	97	9	in	in	ADP
eurjchem-371	97	10	co‐solvent	co‐solvent	ADJ
eurjchem-371	97	11	techniques	technique	NOUN
eurjchem-371	97	12	[	[	X
eurjchem-371	97	13	20,21	20,21	NUM
eurjchem-371	97	14	]	]	PUNCT
eurjchem-371	97	15	.	.	PUNCT
eurjchem-371	98	1	2.2.5	2.2.5	NUM
eurjchem-371	98	2	.	.	PUNCT
eurjchem-371	98	3	uv‐ph	uv‐ph	ADJ
eurjchem-371	98	4	titration	titration	NOUN
eurjchem-371	98	5	in	in	ADP
eurjchem-371	98	6	aqueous	aqueous	ADJ
eurjchem-371	98	7	medium	medium	NOUN
eurjchem-371	98	8	and	and	CCONJ
eurjchem-371	98	9	in	in	ADP
eurjchem-371	98	10	co‐solvent	co‐solvent	ADJ
eurjchem-371	98	11	–	–	PUNCT
eurjchem-371	98	12	water	water	NOUN
eurjchem-371	98	13	mixtures	mixture	VERB
eurjchem-371	98	14	the	the	DET
eurjchem-371	98	15	uv	uv	NOUN
eurjchem-371	98	16	/	/	SYM
eurjchem-371	98	17	ph	ph	ADJ
eurjchem-371	98	18	titrations	titration	NOUN
eurjchem-371	98	19	were	be	AUX
eurjchem-371	98	20	performed	perform	VERB
eurjchem-371	98	21	using	use	VERB
eurjchem-371	98	22	d‐pas	d‐pas	PROPN
eurjchem-371	98	23	technique	technique	NOUN
eurjchem-371	98	24	(	(	PUNCT
eurjchem-371	98	25	sirius	sirius	PROPN
eurjchem-371	98	26	analytical	analytical	PROPN
eurjchem-371	98	27	instruments	instruments	PROPN
eurjchem-371	98	28	ltd	ltd	PROPN
eurjchem-371	98	29	.	.	PROPN
eurjchem-371	98	30	,	,	PUNCT
eurjchem-371	98	31	forest	forest	NOUN
eurjchem-371	98	32	row	row	NOUN
eurjchem-371	98	33	,	,	PUNCT
eurjchem-371	98	34	uk	uk	PROPN
eurjchem-371	98	35	)	)	PUNCT
eurjchem-371	98	36	attached	attach	VERB
eurjchem-371	98	37	to	to	ADP
eurjchem-371	98	38	a	a	DET
eurjchem-371	98	39	glpka	glpka	NOUN
eurjchem-371	99	1	[	[	X
eurjchem-371	99	2	26	26	NUM
eurjchem-371	99	3	]	]	PUNCT
eurjchem-371	99	4	.	.	PUNCT
eurjchem-371	100	1	the	the	DET
eurjchem-371	100	2	pka	pka	PROPN
eurjchem-371	100	3	and	and	CCONJ
eurjchem-371	100	4	pska	pska	NOUN
eurjchem-371	100	5	values	value	NOUN
eurjchem-371	100	6	were	be	AUX
eurjchem-371	100	7	calculated	calculate	VERB
eurjchem-371	100	8	using	use	VERB
eurjchem-371	100	9	refinementprotm	refinementprotm	ADJ
eurjchem-371	100	10	software	software	NOUN
eurjchem-371	100	11	.	.	PUNCT
eurjchem-371	101	1	spectrophoto‐	spectrophoto‐	PROPN
eurjchem-371	101	2	metric	metric	ADJ
eurjchem-371	101	3	method	method	NOUN
eurjchem-371	101	4	can	can	AUX
eurjchem-371	101	5	only	only	ADV
eurjchem-371	101	6	be	be	AUX
eurjchem-371	101	7	applied	apply	VERB
eurjchem-371	101	8	,	,	PUNCT
eurjchem-371	101	9	for	for	ADP
eurjchem-371	101	10	pka	pka	PROPN
eurjchem-371	101	11	/	/	SYM
eurjchem-371	101	12	pska	pska	NOUN
eurjchem-371	101	13	measure‐	measure‐	NOUN
eurjchem-371	101	14	ment	ment	NOUN
eurjchem-371	101	15	,	,	PUNCT
eurjchem-371	101	16	to	to	ADP
eurjchem-371	101	17	those	those	DET
eurjchem-371	101	18	compounds	compound	NOUN
eurjchem-371	101	19	which	which	PRON
eurjchem-371	101	20	has	have	VERB
eurjchem-371	101	21	a	a	DET
eurjchem-371	101	22	chromophore	chromophore	NOUN
eurjchem-371	101	23	at	at	ADP
eurjchem-371	101	24	close	close	ADJ
eurjchem-371	101	25	proximity	proximity	NOUN
eurjchem-371	101	26	of	of	ADP
eurjchem-371	101	27	the	the	DET
eurjchem-371	101	28	ionization	ionization	NOUN
eurjchem-371	101	29	centre	centre	NOUN
eurjchem-371	101	30	.	.	PUNCT
eurjchem-371	102	1	this	this	PRON
eurjchem-371	102	2	would	would	AUX
eurjchem-371	102	3	help	help	VERB
eurjchem-371	102	4	to	to	PART
eurjchem-371	102	5	have	have	VERB
eurjchem-371	102	6	a	a	DET
eurjchem-371	102	7	sufficient	sufficient	ADJ
eurjchem-371	102	8	change	change	NOUN
eurjchem-371	102	9	in	in	ADP
eurjchem-371	102	10	absorbance	absorbance	NOUN
eurjchem-371	102	11	as	as	ADP
eurjchem-371	102	12	a	a	DET
eurjchem-371	102	13	function	function	NOUN
eurjchem-371	102	14	of	of	ADP
eurjchem-371	102	15	ph	ph	PROPN
eurjchem-371	102	16	.	.	PROPN
eurjchem-371	102	17	of	of	ADP
eurjchem-371	102	18	all	all	DET
eurjchem-371	102	19	the	the	DET
eurjchem-371	102	20	selected	select	VERB
eurjchem-371	102	21	drugs	drug	NOUN
eurjchem-371	102	22	in	in	ADP
eurjchem-371	102	23	the	the	DET
eurjchem-371	102	24	present	present	ADJ
eurjchem-371	102	25	investigation	investigation	NOUN
eurjchem-371	102	26	,	,	PUNCT
eurjchem-371	102	27	only	only	ADV
eurjchem-371	102	28	aml	aml	PROPN
eurjchem-371	102	29	,	,	PUNCT
eurjchem-371	102	30	pro	pro	ADJ
eurjchem-371	102	31	,	,	PUNCT
eurjchem-371	102	32	glc	glc	PROPN
eurjchem-371	102	33	and	and	CCONJ
eurjchem-371	102	34	atn	atn	PROPN
eurjchem-371	102	35	is	be	AUX
eurjchem-371	102	36	found	find	VERB
eurjchem-371	102	37	to	to	PART
eurjchem-371	102	38	have	have	VERB
eurjchem-371	102	39	chromophores	chromophore	NOUN
eurjchem-371	102	40	in	in	ADP
eurjchem-371	102	41	which	which	PRON
eurjchem-371	102	42	ionisation	ionisation	NOUN
eurjchem-371	102	43	groups	group	NOUN
eurjchem-371	102	44	were	be	AUX
eurjchem-371	102	45	part	part	NOUN
eurjchem-371	102	46	of	of	ADP
eurjchem-371	102	47	the	the	DET
eurjchem-371	102	48	conjugation	conjugation	NOUN
eurjchem-371	102	49	and	and	CCONJ
eurjchem-371	102	50	produced	produce	VERB
eurjchem-371	102	51	enough	enough	ADJ
eurjchem-371	102	52	changes	change	NOUN
eurjchem-371	102	53	in	in	ADP
eurjchem-371	102	54	the	the	DET
eurjchem-371	102	55	absorbance	absorbance	NOUN
eurjchem-371	102	56	with	with	ADP
eurjchem-371	102	57	change	change	NOUN
eurjchem-371	102	58	in	in	ADP
eurjchem-371	102	59	the	the	DET
eurjchem-371	102	60	ph	ph	NOUN
eurjchem-371	102	61	.	.	PROPN
eurjchem-371	102	62	in	in	ADP
eurjchem-371	102	63	each	each	DET
eurjchem-371	102	64	experiment	experiment	NOUN
eurjchem-371	102	65	,	,	PUNCT
eurjchem-371	102	66	a	a	DET
eurjchem-371	102	67	10.0	10.0	NUM
eurjchem-371	102	68	mm	mm	NOUN
eurjchem-371	102	69	stock	stock	NOUN
eurjchem-371	102	70	solution	solution	NOUN
eurjchem-371	102	71	of	of	ADP
eurjchem-371	102	72	the	the	DET
eurjchem-371	102	73	sample	sample	NOUN
eurjchem-371	102	74	was	be	AUX
eurjchem-371	102	75	prepared	prepare	VERB
eurjchem-371	102	76	in	in	ADP
eurjchem-371	102	77	dmso	dmso	NOUN
eurjchem-371	102	78	.	.	PUNCT
eurjchem-371	103	1	50	50	NUM
eurjchem-371	103	2	µl	µl	ADP
eurjchem-371	103	3	aliquot	aliquot	NOUN
eurjchem-371	103	4	of	of	ADP
eurjchem-371	103	5	the	the	DET
eurjchem-371	103	6	stock	stock	NOUN
eurjchem-371	103	7	solution	solution	NOUN
eurjchem-371	103	8	was	be	AUX
eurjchem-371	103	9	then	then	ADV
eurjchem-371	103	10	diluted	dilute	VERB
eurjchem-371	103	11	to	to	ADP
eurjchem-371	103	12	10	10	NUM
eurjchem-371	103	13	ml	ml	NOUN
eurjchem-371	103	14	with	with	ADP
eurjchem-371	103	15	0.15	0.15	NUM
eurjchem-371	103	16	m	m	NOUN
eurjchem-371	103	17	kcl	kcl	NOUN
eurjchem-371	103	18	solution	solution	NOUN
eurjchem-371	103	19	containing	contain	VERB
eurjchem-371	103	20	0.25	0.25	NUM
eurjchem-371	103	21	ml	ml	NOUN
eurjchem-371	103	22	of	of	ADP
eurjchem-371	103	23	phosphate	phosphate	ADJ
eurjchem-371	103	24	buffer	buffer	NOUN
eurjchem-371	103	25	(	(	PUNCT
eurjchem-371	103	26	di‐potassium	di‐potassium	NOUN
eurjchem-371	103	27	hydrogen	hydrogen	NOUN
eurjchem-371	103	28	phosphate	phosphate	NOUN
eurjchem-371	103	29	)	)	PUNCT
eurjchem-371	103	30	to	to	PART
eurjchem-371	103	31	produce	produce	VERB
eurjchem-371	103	32	the	the	DET
eurjchem-371	103	33	required	require	VERB
eurjchem-371	103	34	sample	sample	NOUN
eurjchem-371	103	35	concentration	concentration	NOUN
eurjchem-371	103	36	.	.	PUNCT
eurjchem-371	104	1	blank	blank	ADJ
eurjchem-371	104	2	spectra	spectra	PROPN
eurjchem-371	104	3	are	be	AUX
eurjchem-371	104	4	collected	collect	VERB
eurjchem-371	104	5	from	from	ADP
eurjchem-371	104	6	reference	reference	NOUN
eurjchem-371	104	7	vial	vial	ADJ
eurjchem-371	104	8	without	without	ADP
eurjchem-371	104	9	sample	sample	NOUN
eurjchem-371	104	10	but	but	CCONJ
eurjchem-371	104	11	with	with	ADP
eurjchem-371	104	12	50	50	NUM
eurjchem-371	104	13	µl	µl	NOUN
eurjchem-371	104	14	of	of	ADP
eurjchem-371	104	15	dmso	dmso	NOUN
eurjchem-371	104	16	.	.	PUNCT
eurjchem-371	105	1	for	for	ADP
eurjchem-371	105	2	bases	basis	NOUN
eurjchem-371	105	3	,	,	PUNCT
eurjchem-371	105	4	in	in	ADP
eurjchem-371	105	5	each	each	DET
eurjchem-371	105	6	experiment	experiment	NOUN
eurjchem-371	105	7	,	,	PUNCT
eurjchem-371	105	8	the	the	DET
eurjchem-371	105	9	ph	ph	NOUN
eurjchem-371	105	10	of	of	ADP
eurjchem-371	105	11	the	the	DET
eurjchem-371	105	12	sample	sample	NOUN
eurjchem-371	105	13	solution	solution	NOUN
eurjchem-371	105	14	was	be	AUX
eurjchem-371	105	15	adjusted	adjust	VERB
eurjchem-371	105	16	to	to	ADP
eurjchem-371	105	17	ph=2	ph=2	NOUN
eurjchem-371	105	18	using	use	VERB
eurjchem-371	105	19	0.5	0.5	NUM
eurjchem-371	105	20	m	m	NOUN
eurjchem-371	105	21	hcl	hcl	PROPN
eurjchem-371	105	22	and	and	CCONJ
eurjchem-371	105	23	then	then	ADV
eurjchem-371	105	24	titrated	titrate	VERB
eurjchem-371	105	25	with	with	ADP
eurjchem-371	105	26	0.5	0.5	NUM
eurjchem-371	105	27	m	m	NOUN
eurjchem-371	105	28	koh	koh	PROPN
eurjchem-371	105	29	to	to	PART
eurjchem-371	105	30	ph=12	ph=12	PROPN
eurjchem-371	105	31	.	.	PROPN
eurjchem-371	106	1	for	for	ADP
eurjchem-371	106	2	acids	acid	NOUN
eurjchem-371	106	3	,	,	PUNCT
eurjchem-371	106	4	titration	titration	NOUN
eurjchem-371	106	5	is	be	AUX
eurjchem-371	106	6	started	start	VERB
eurjchem-371	106	7	from	from	ADP
eurjchem-371	106	8	high	high	ADJ
eurjchem-371	106	9	to	to	ADP
eurjchem-371	106	10	low	low	ADJ
eurjchem-371	106	11	ph	ph	PROPN
eurjchem-371	106	12	.	.	PROPN
eurjchem-371	106	13	spectral	spectral	ADJ
eurjchem-371	106	14	data	datum	NOUN
eurjchem-371	106	15	were	be	AUX
eurjchem-371	106	16	recorded	record	VERB
eurjchem-371	106	17	in	in	ADP
eurjchem-371	106	18	the	the	DET
eurjchem-371	106	19	region	region	NOUN
eurjchem-371	106	20	of	of	ADP
eurjchem-371	106	21	200–700	200–700	NUM
eurjchem-371	106	22	nm	nm	NOUN
eurjchem-371	106	23	after	after	ADP
eurjchem-371	106	24	each	each	DET
eurjchem-371	106	25	ph	ph	ADJ
eurjchem-371	106	26	measurement	measurement	NOUN
eurjchem-371	106	27	.	.	PUNCT
eurjchem-371	107	1	all	all	DET
eurjchem-371	107	2	measurements	measurement	NOUN
eurjchem-371	107	3	were	be	AUX
eurjchem-371	107	4	performed	perform	VERB
eurjchem-371	107	5	in	in	ADP
eurjchem-371	107	6	all	all	DET
eurjchem-371	107	7	the	the	DET
eurjchem-371	107	8	four	four	NUM
eurjchem-371	107	9	selected	select	VERB
eurjchem-371	107	10	co‐solvents	co‐solvent	NOUN
eurjchem-371	107	11	at	at	ADP
eurjchem-371	107	12	least	least	ADJ
eurjchem-371	107	13	in	in	ADP
eurjchem-371	107	14	three	three	NUM
eurjchem-371	107	15	different	different	ADJ
eurjchem-371	107	16	wt%	wt%	ADJ
eurjchem-371	107	17	,	,	PUNCT
eurjchem-371	107	18	at	at	ADP
eurjchem-371	107	19	constant	constant	ADJ
eurjchem-371	107	20	ionic	ionic	ADJ
eurjchem-371	107	21	strength	strength	NOUN
eurjchem-371	107	22	(	(	PUNCT
eurjchem-371	107	23	i	i	NOUN
eurjchem-371	107	24	=	=	NOUN
eurjchem-371	107	25	0.15	0.15	NUM
eurjchem-371	107	26	m	m	NOUN
eurjchem-371	107	27	kcl	kcl	NOUN
eurjchem-371	107	28	)	)	PUNCT
eurjchem-371	107	29	and	and	CCONJ
eurjchem-371	107	30	temperature	temperature	NOUN
eurjchem-371	107	31	(	(	PUNCT
eurjchem-371	107	32	25.0±0.5	25.0±0.5	NUM
eurjchem-371	107	33	oc	oc	NOUN
eurjchem-371	107	34	)	)	PUNCT
eurjchem-371	107	35	under	under	ADP
eurjchem-371	107	36	argon	argon	NOUN
eurjchem-371	107	37	atmosphere	atmosphere	NOUN
eurjchem-371	107	38	.	.	PUNCT
eurjchem-371	108	1	three	three	NUM
eurjchem-371	108	2	parallel	parallel	ADJ
eurjchem-371	108	3	measurements	measurement	NOUN
eurjchem-371	108	4	were	be	AUX
eurjchem-371	108	5	carried	carry	VERB
eurjchem-371	108	6	out	out	ADP
eurjchem-371	108	7	.	.	PUNCT
eurjchem-371	109	1	sample	sample	NOUN
eurjchem-371	109	2	concent‐	concent‐	NOUN
eurjchem-371	109	3	rations	ration	NOUN
eurjchem-371	109	4	of	of	ADP
eurjchem-371	109	5	5–100	5–100	NUM
eurjchem-371	109	6	µm	µm	NUM
eurjchem-371	109	7	were	be	AUX
eurjchem-371	109	8	used	use	VERB
eurjchem-371	109	9	for	for	ADP
eurjchem-371	109	10	uv	uv	NOUN
eurjchem-371	109	11	/	/	SYM
eurjchem-371	109	12	ph	ph	NOUN
eurjchem-371	109	13	titration	titration	NOUN
eurjchem-371	109	14	.	.	PUNCT
eurjchem-371	110	1	the	the	DET
eurjchem-371	110	2	pka	pka	PROPN
eurjchem-371	110	3	values	value	NOUN
eurjchem-371	110	4	of	of	ADP
eurjchem-371	110	5	samples	sample	NOUN
eurjchem-371	110	6	were	be	AUX
eurjchem-371	110	7	calculated	calculate	VERB
eurjchem-371	110	8	by	by	ADP
eurjchem-371	110	9	target	target	NOUN
eurjchem-371	110	10	factor	factor	NOUN
eurjchem-371	110	11	analysis	analysis	NOUN
eurjchem-371	110	12	[	[	X
eurjchem-371	110	13	27	27	NUM
eurjchem-371	110	14	]	]	PUNCT
eurjchem-371	110	15	.	.	PUNCT
eurjchem-371	111	1	2.2.6	2.2.6	X
eurjchem-371	111	2	.	.	PUNCT
eurjchem-371	112	1	potentiometric	potentiometric	PROPN
eurjchem-371	112	2	log	log	VERB
eurjchem-371	112	3	p	p	NOUN
eurjchem-371	112	4	determination	determination	NOUN
eurjchem-371	112	5	(	(	PUNCT
eurjchem-371	112	6	octanol	octanol	NOUN
eurjchem-371	112	7	/	/	SYM
eurjchem-371	112	8	water	water	NOUN
eurjchem-371	112	9	system	system	NOUN
eurjchem-371	112	10	)	)	PUNCT
eurjchem-371	112	11	the	the	DET
eurjchem-371	112	12	logarithm	logarithm	NOUN
eurjchem-371	112	13	of	of	ADP
eurjchem-371	112	14	octanol	octanol	NOUN
eurjchem-371	112	15	/	/	SYM
eurjchem-371	112	16	water	water	NOUN
eurjchem-371	112	17	partition	partition	NOUN
eurjchem-371	112	18	coefficient	coefficient	NOUN
eurjchem-371	112	19	(	(	PUNCT
eurjchem-371	112	20	log	log	PROPN
eurjchem-371	112	21	poct	poct	PROPN
eurjchem-371	112	22	)	)	PUNCT
eurjchem-371	112	23	was	be	AUX
eurjchem-371	112	24	determined	determine	VERB
eurjchem-371	112	25	by	by	ADP
eurjchem-371	112	26	the	the	DET
eurjchem-371	112	27	dual‐phase	dual‐phase	NOUN
eurjchem-371	112	28	potentiometric	potentiometric	ADJ
eurjchem-371	112	29	titration	titration	NOUN
eurjchem-371	112	30	[	[	X
eurjchem-371	112	31	28,29	28,29	X
eurjchem-371	112	32	]	]	PUNCT
eurjchem-371	112	33	.	.	PUNCT
eurjchem-371	113	1	log	log	VERB
eurjchem-371	113	2	p	p	NOUN
eurjchem-371	113	3	(	(	PUNCT
eurjchem-371	113	4	partition	partition	NOUN
eurjchem-371	113	5	coefficient	coefficient	NOUN
eurjchem-371	113	6	)	)	PUNCT
eurjchem-371	113	7	is	be	AUX
eurjchem-371	113	8	a	a	DET
eurjchem-371	113	9	measure	measure	NOUN
eurjchem-371	113	10	of	of	ADP
eurjchem-371	113	11	the	the	DET
eurjchem-371	113	12	lipophilicity	lipophilicity	NOUN
eurjchem-371	113	13	of	of	ADP
eurjchem-371	113	14	a	a	DET
eurjchem-371	113	15	compound	compound	NOUN
eurjchem-371	113	16	.	.	PUNCT
eurjchem-371	114	1	a	a	DET
eurjchem-371	114	2	blank	blank	ADJ
eurjchem-371	114	3	acid‐base	acid‐base	NOUN
eurjchem-371	114	4	titration	titration	NOUN
eurjchem-371	114	5	is	be	AUX
eurjchem-371	114	6	compared	compare	VERB
eurjchem-371	114	7	to	to	ADP
eurjchem-371	114	8	a	a	DET
eurjchem-371	114	9	titration	titration	NOUN
eurjchem-371	114	10	in	in	ADP
eurjchem-371	114	11	the	the	DET
eurjchem-371	114	12	presence	presence	NOUN
eurjchem-371	114	13	of	of	ADP
eurjchem-371	114	14	the	the	DET
eurjchem-371	114	15	compound	compound	NOUN
eurjchem-371	114	16	.	.	PUNCT
eurjchem-371	115	1	a	a	DET
eurjchem-371	115	2	difference	difference	NOUN
eurjchem-371	115	3	curve	curve	NOUN
eurjchem-371	115	4	is	be	AUX
eurjchem-371	115	5	produced	produce	VERB
eurjchem-371	115	6	from	from	ADP
eurjchem-371	115	7	the	the	DET
eurjchem-371	115	8	volume	volume	NOUN
eurjchem-371	115	9	of	of	ADP
eurjchem-371	115	10	koh	koh	PROPN
eurjchem-371	115	11	required	require	VERB
eurjchem-371	115	12	to	to	PART
eurjchem-371	115	13	reach	reach	VERB
eurjchem-371	115	14	a	a	DET
eurjchem-371	115	15	given	give	VERB
eurjchem-371	115	16	ph	ph	NOUN
eurjchem-371	115	17	with	with	ADP
eurjchem-371	115	18	and	and	CCONJ
eurjchem-371	115	19	without	without	ADP
eurjchem-371	115	20	the	the	DET
eurjchem-371	115	21	compound	compound	NOUN
eurjchem-371	115	22	.	.	PUNCT
eurjchem-371	116	1	the	the	DET
eurjchem-371	116	2	difference	difference	NOUN
eurjchem-371	116	3	curve	curve	NOUN
eurjchem-371	116	4	is	be	AUX
eurjchem-371	116	5	converted	convert	VERB
eurjchem-371	116	6	to	to	ADP
eurjchem-371	116	7	a	a	DET
eurjchem-371	116	8	bjerrum	bjerrum	NOUN
eurjchem-371	116	9	plot	plot	NOUN
eurjchem-371	116	10	.	.	PUNCT
eurjchem-371	117	1	the	the	DET
eurjchem-371	117	2	axes	axis	NOUN
eurjchem-371	117	3	are	be	AUX
eurjchem-371	117	4	reversed	reverse	VERB
eurjchem-371	117	5	and	and	CCONJ
eurjchem-371	117	6	the	the	DET
eurjchem-371	117	7	volume	volume	NOUN
eurjchem-371	117	8	difference	difference	NOUN
eurjchem-371	117	9	is	be	AUX
eurjchem-371	117	10	converted	convert	VERB
eurjchem-371	117	11	to	to	ADP
eurjchem-371	117	12	the	the	DET
eurjchem-371	117	13	average	average	ADJ
eurjchem-371	117	14	number	number	NOUN
eurjchem-371	117	15	of	of	ADP
eurjchem-371	117	16	bound	bind	VERB
eurjchem-371	117	17	protons	proton	NOUN
eurjchem-371	117	18	per	per	ADP
eurjchem-371	117	19	molecule	molecule	NOUN
eurjchem-371	117	20	(	(	PUNCT
eurjchem-371	117	21	½á	½á	NOUN
eurjchem-371	117	22	)	)	PUNCT
eurjchem-371	117	23	(	(	PUNCT
eurjchem-371	117	24	figure	figure	NOUN
eurjchem-371	117	25	1	1	NUM
eurjchem-371	117	26	)	)	PUNCT
eurjchem-371	117	27	.	.	PUNCT
eurjchem-371	118	1	titrations	titration	NOUN
eurjchem-371	118	2	are	be	AUX
eurjchem-371	118	3	then	then	ADV
eurjchem-371	118	4	performed	perform	VERB
eurjchem-371	118	5	in	in	ADP
eurjchem-371	118	6	the	the	DET
eurjchem-371	118	7	presence	presence	NOUN
eurjchem-371	118	8	of	of	ADP
eurjchem-371	118	9	varying	vary	VERB
eurjchem-371	118	10	amounts	amount	NOUN
eurjchem-371	118	11	of	of	ADP
eurjchem-371	118	12	partition	partition	NOUN
eurjchem-371	118	13	solvent	solvent	NOUN
eurjchem-371	118	14	,	,	PUNCT
eurjchem-371	118	15	octanol	octanol	NOUN
eurjchem-371	118	16	.	.	PUNCT
eurjchem-371	119	1	from	from	ADP
eurjchem-371	119	2	the	the	DET
eurjchem-371	119	3	octanol‐	octanol‐	NOUN
eurjchem-371	119	4	containing	contain	VERB
eurjchem-371	119	5	titrations	titration	NOUN
eurjchem-371	119	6	the	the	DET
eurjchem-371	119	7	apparent	apparent	ADJ
eurjchem-371	119	8	ionization	ionization	NOUN
eurjchem-371	119	9	constants	constant	NOUN
eurjchem-371	119	10	(	(	PUNCT
eurjchem-371	119	11	poka	poka	NOUN
eurjchem-371	119	12	)	)	PUNCT
eurjchem-371	119	13	and	and	CCONJ
eurjchem-371	119	14	then	then	ADV
eurjchem-371	119	15	the	the	DET
eurjchem-371	119	16	log	log	NOUN
eurjchem-371	119	17	p	p	NOUN
eurjchem-371	119	18	values	value	NOUN
eurjchem-371	119	19	were	be	AUX
eurjchem-371	119	20	estimated	estimate	VERB
eurjchem-371	119	21	and	and	CCONJ
eurjchem-371	119	22	refined	refine	VERB
eurjchem-371	119	23	by	by	ADP
eurjchem-371	119	24	a	a	DET
eurjchem-371	119	25	weighted	weight	VERB
eurjchem-371	119	26	non‐linear	non‐linear	ADJ
eurjchem-371	119	27	least	least	ADJ
eurjchem-371	119	28	squares	square	NOUN
eurjchem-371	119	29	procedure	procedure	NOUN
eurjchem-371	119	30	where	where	SCONJ
eurjchem-371	119	31	the	the	DET
eurjchem-371	119	32	pka	pka	PROPN
eurjchem-371	119	33	values	value	NOUN
eurjchem-371	119	34	were	be	AUX
eurjchem-371	119	35	used	use	VERB
eurjchem-371	119	36	as	as	ADP
eurjchem-371	119	37	unrefined	unrefined	ADJ
eurjchem-371	119	38	contributions	contribution	NOUN
eurjchem-371	119	39	.	.	PUNCT
eurjchem-371	120	1	(	(	PUNCT
eurjchem-371	120	2	a	a	X
eurjchem-371	120	3	)	)	PUNCT
eurjchem-371	120	4	(	(	PUNCT
eurjchem-371	120	5	b	b	X
eurjchem-371	120	6	)	)	PUNCT
eurjchem-371	120	7	(	(	PUNCT
eurjchem-371	120	8	c	c	X
eurjchem-371	120	9	)	)	PUNCT
eurjchem-371	120	10	(	(	PUNCT
eurjchem-371	120	11	d	d	X
eurjchem-371	120	12	)	)	PUNCT
eurjchem-371	120	13	figure	figure	NOUN
eurjchem-371	120	14	1	1	NUM
eurjchem-371	120	15	.	.	PUNCT
eurjchem-371	121	1	graphs	graph	NOUN
eurjchem-371	121	2	showing	show	VERB
eurjchem-371	121	3	(	(	PUNCT
eurjchem-371	121	4	a	a	NOUN
eurjchem-371	121	5	)	)	PUNCT
eurjchem-371	121	6	blank	blank	ADJ
eurjchem-371	121	7	titration	titration	NOUN
eurjchem-371	121	8	curve	curve	NOUN
eurjchem-371	121	9	,	,	PUNCT
eurjchem-371	121	10	(	(	PUNCT
eurjchem-371	121	11	b	b	NOUN
eurjchem-371	121	12	)	)	PUNCT
eurjchem-371	121	13	with	with	ADP
eurjchem-371	121	14	sample	sample	NOUN
eurjchem-371	121	15	,	,	PUNCT
eurjchem-371	121	16	(	(	PUNCT
eurjchem-371	121	17	c	c	NOUN
eurjchem-371	121	18	)	)	PUNCT
eurjchem-371	121	19	volume	volume	NOUN
eurjchem-371	121	20	difference	difference	NOUN
eurjchem-371	121	21	curve	curve	NOUN
eurjchem-371	121	22	and	and	CCONJ
eurjchem-371	121	23	(	(	PUNCT
eurjchem-371	121	24	d	d	NOUN
eurjchem-371	121	25	)	)	PUNCT
eurjchem-371	121	26	bjerrum	bjerrum	NOUN
eurjchem-371	121	27	plot	plot	NOUN
eurjchem-371	121	28	.	.	PUNCT
eurjchem-371	122	1	about	about	ADP
eurjchem-371	122	2	1‐2	1‐2	PROPN
eurjchem-371	122	3	mg	mg	NUM
eurjchem-371	122	4	of	of	ADP
eurjchem-371	122	5	sample	sample	NOUN
eurjchem-371	122	6	having	have	VERB
eurjchem-371	122	7	10	10	NUM
eurjchem-371	122	8	ml	ml	NOUN
eurjchem-371	122	9	of	of	ADP
eurjchem-371	122	10	0.15	0.15	NUM
eurjchem-371	122	11	m	m	NOUN
eurjchem-371	122	12	kcl	kcl	PROPN
eurjchem-371	122	13	was	be	AUX
eurjchem-371	122	14	titrated	titrate	VERB
eurjchem-371	122	15	under	under	ADP
eurjchem-371	122	16	the	the	DET
eurjchem-371	122	17	same	same	ADJ
eurjchem-371	122	18	conditions	condition	NOUN
eurjchem-371	122	19	as	as	ADP
eurjchem-371	122	20	in	in	ADP
eurjchem-371	122	21	pka	pka	NOUN
eurjchem-371	122	22	determinations	determination	NOUN
eurjchem-371	122	23	but	but	CCONJ
eurjchem-371	122	24	in	in	ADP
eurjchem-371	122	25	the	the	DET
eurjchem-371	122	26	presence	presence	NOUN
eurjchem-371	122	27	of	of	ADP
eurjchem-371	122	28	a	a	DET
eurjchem-371	122	29	partitioning	partitioning	ADJ
eurjchem-371	122	30	solvent	solvent	NOUN
eurjchem-371	122	31	,	,	PUNCT
eurjchem-371	122	32	water‐saturated	water‐saturate	VERB
eurjchem-371	122	33	octanol	octanol	NOUN
eurjchem-371	122	34	.	.	PUNCT
eurjchem-371	123	1	each	each	DET
eurjchem-371	123	2	sample	sample	NOUN
eurjchem-371	123	3	was	be	AUX
eurjchem-371	123	4	analysed	analyse	VERB
eurjchem-371	123	5	in	in	ADP
eurjchem-371	123	6	triplicate	triplicate	NOUN
eurjchem-371	123	7	,	,	PUNCT
eurjchem-371	123	8	with	with	ADP
eurjchem-371	123	9	three	three	NUM
eurjchem-371	123	10	titrations	titration	NOUN
eurjchem-371	123	11	in	in	ADP
eurjchem-371	123	12	each	each	DET
eurjchem-371	123	13	experiment	experiment	NOUN
eurjchem-371	123	14	(	(	PUNCT
eurjchem-371	123	15	beaker	beaker	NOUN
eurjchem-371	123	16	)	)	PUNCT
eurjchem-371	123	17	.	.	PUNCT
eurjchem-371	124	1	solid	solid	ADJ
eurjchem-371	124	2	sample	sample	NOUN
eurjchem-371	124	3	was	be	AUX
eurjchem-371	124	4	weighed	weigh	VERB
eurjchem-371	124	5	into	into	ADP
eurjchem-371	124	6	each	each	DET
eurjchem-371	124	7	beaker	beaker	NOUN
eurjchem-371	124	8	and	and	CCONJ
eurjchem-371	124	9	specified	specify	VERB
eurjchem-371	124	10	volume	volume	NOUN
eurjchem-371	124	11	of	of	ADP
eurjchem-371	124	12	octanol	octanol	NOUN
eurjchem-371	124	13	(	(	PUNCT
eurjchem-371	124	14	table	table	NOUN
eurjchem-371	124	15	1	1	NUM
eurjchem-371	124	16	)	)	PUNCT
eurjchem-371	124	17	is	be	AUX
eurjchem-371	124	18	added	add	VERB
eurjchem-371	124	19	manually	manually	ADV
eurjchem-371	124	20	at	at	ADP
eurjchem-371	124	21	the	the	DET
eurjchem-371	124	22	beginning	beginning	NOUN
eurjchem-371	124	23	of	of	ADP
eurjchem-371	124	24	first	first	ADJ
eurjchem-371	124	25	titration	titration	NOUN
eurjchem-371	124	26	and	and	CCONJ
eurjchem-371	124	27	sonicated	sonicate	VERB
eurjchem-371	124	28	for	for	ADP
eurjchem-371	124	29	30	30	NUM
eurjchem-371	124	30	to	to	PART
eurjchem-371	124	31	45	45	NUM
eurjchem-371	124	32	minutes	minute	NOUN
eurjchem-371	124	33	for	for	ADP
eurjchem-371	124	34	its	its	PRON
eurjchem-371	124	35	dissolution	dissolution	NOUN
eurjchem-371	124	36	.	.	PUNCT
eurjchem-371	125	1	titration	titration	NOUN
eurjchem-371	125	2	is	be	AUX
eurjchem-371	125	3	then	then	ADV
eurjchem-371	125	4	carried	carry	VERB
eurjchem-371	125	5	out	out	ADP
eurjchem-371	125	6	as	as	ADP
eurjchem-371	125	7	per	per	ADP
eurjchem-371	125	8	section	section	NOUN
eurjchem-371	125	9	2.2.3	2.2.3	NUM
eurjchem-371	125	10	.	.	PUNCT
eurjchem-371	126	1	in	in	ADP
eurjchem-371	126	2	second	second	ADJ
eurjchem-371	126	3	and	and	CCONJ
eurjchem-371	126	4	third	third	ADJ
eurjchem-371	126	5	titration	titration	NOUN
eurjchem-371	126	6	,	,	PUNCT
eurjchem-371	126	7	octanol	octanol	NOUN
eurjchem-371	126	8	was	be	AUX
eurjchem-371	126	9	added	add	VERB
eurjchem-371	126	10	automatically	automatically	ADV
eurjchem-371	126	11	by	by	ADP
eurjchem-371	126	12	the	the	DET
eurjchem-371	126	13	instrument	instrument	NOUN
eurjchem-371	126	14	through	through	ADP
eurjchem-371	126	15	the	the	DET
eurjchem-371	126	16	dispenser	dispenser	NOUN
eurjchem-371	126	17	.	.	PUNCT
eurjchem-371	127	1	the	the	DET
eurjchem-371	127	2	total	total	ADJ
eurjchem-371	127	3	volume	volume	NOUN
eurjchem-371	127	4	of	of	ADP
eurjchem-371	127	5	the	the	DET
eurjchem-371	127	6	beaker	beaker	NOUN
eurjchem-371	127	7	is	be	AUX
eurjchem-371	127	8	always	always	ADV
eurjchem-371	127	9	maintained	maintain	VERB
eurjchem-371	127	10	less	less	ADJ
eurjchem-371	127	11	than	than	ADP
eurjchem-371	127	12	15	15	NUM
eurjchem-371	127	13	ml	ml	NOUN
eurjchem-371	127	14	(	(	PUNCT
eurjchem-371	127	15	working	work	VERB
eurjchem-371	127	16	capacity	capacity	NOUN
eurjchem-371	127	17	of	of	ADP
eurjchem-371	127	18	each	each	DET
eurjchem-371	127	19	titration	titration	NOUN
eurjchem-371	127	20	vessel	vessel	NOUN
eurjchem-371	127	21	)	)	PUNCT
eurjchem-371	127	22	.	.	PUNCT
eurjchem-371	128	1	2.2.7	2.2.7	X
eurjchem-371	128	2	.	.	PUNCT
eurjchem-371	129	1	hplc	hplc	NOUN
eurjchem-371	129	2	log	log	VERB
eurjchem-371	129	3	p	p	NOUN
eurjchem-371	129	4	determination	determination	NOUN
eurjchem-371	129	5	the	the	DET
eurjchem-371	129	6	distribution	distribution	NOUN
eurjchem-371	129	7	coefficient	coefficient	NOUN
eurjchem-371	129	8	(	(	PUNCT
eurjchem-371	129	9	log	log	NOUN
eurjchem-371	129	10	d	d	NOUN
eurjchem-371	129	11	)	)	PUNCT
eurjchem-371	129	12	is	be	AUX
eurjchem-371	129	13	determined	determine	VERB
eurjchem-371	129	14	by	by	ADP
eurjchem-371	129	15	correlation	correlation	NOUN
eurjchem-371	129	16	of	of	ADP
eurjchem-371	129	17	the	the	DET
eurjchem-371	129	18	hplc	hplc	NOUN
eurjchem-371	129	19	retention	retention	NOUN
eurjchem-371	129	20	time	time	NOUN
eurjchem-371	129	21	of	of	ADP
eurjchem-371	129	22	compound	compound	NOUN
eurjchem-371	129	23	under	under	ADP
eurjchem-371	129	24	investigation	investigation	NOUN
eurjchem-371	129	25	to	to	ADP
eurjchem-371	129	26	a	a	DET
eurjchem-371	129	27	calibration	calibration	NOUN
eurjchem-371	129	28	curve	curve	NOUN
eurjchem-371	129	29	calculated	calculate	VERB
eurjchem-371	129	30	by	by	ADP
eurjchem-371	129	31	linear	linear	ADJ
eurjchem-371	129	32	regression	regression	NOUN
eurjchem-371	129	33	of	of	ADP
eurjchem-371	129	34	the	the	DET
eurjchem-371	129	35	retention	retention	NOUN
eurjchem-371	129	36	times	time	NOUN
eurjchem-371	129	37	of	of	ADP
eurjchem-371	129	38	the	the	DET
eurjchem-371	129	39	known	know	VERB
eurjchem-371	129	40	log	log	NOUN
eurjchem-371	130	1	d	d	NOUN
eurjchem-371	130	2	values	value	NOUN
eurjchem-371	130	3	at	at	ADP
eurjchem-371	130	4	ph=7.4	ph=7.4	NOUN
eurjchem-371	130	5	of	of	ADP
eurjchem-371	130	6	selected	select	VERB
eurjchem-371	130	7	substances	substance	NOUN
eurjchem-371	130	8	.	.	PUNCT
eurjchem-371	131	1	calibration	calibration	NOUN
eurjchem-371	131	2	of	of	ADP
eurjchem-371	131	3	the	the	DET
eurjchem-371	131	4	system	system	NOUN
eurjchem-371	131	5	is	be	AUX
eurjchem-371	131	6	carried	carry	VERB
eurjchem-371	131	7	out	out	ADP
eurjchem-371	131	8	by	by	ADP
eurjchem-371	131	9	injecting	inject	VERB
eurjchem-371	131	10	dilute	dilute	NOUN
eurjchem-371	131	11	solutions	solution	NOUN
eurjchem-371	131	12	of	of	ADP
eurjchem-371	131	13	a	a	DET
eurjchem-371	131	14	mixture	mixture	NOUN
eurjchem-371	131	15	of	of	ADP
eurjchem-371	131	16	seven	seven	NUM
eurjchem-371	131	17	accurately	accurately	ADV
eurjchem-371	131	18	known	know	VERB
eurjchem-371	131	19	log	log	NOUN
eurjchem-371	131	20	p	p	NOUN
eurjchem-371	131	21	”	"	PUNCT
eurjchem-371	131	22	standards	standard	NOUN
eurjchem-371	131	23	”	"	PUNCT
eurjchem-371	131	24	of	of	ADP
eurjchem-371	131	25	mixed	mixed	ADJ
eurjchem-371	131	26	hydrogen‐bond‐	hydrogen‐bond‐	CCONJ
eurjchem-371	131	27	donor	donor	NOUN
eurjchem-371	131	28	and	and	CCONJ
eurjchem-371	131	29	‐acceptor	‐acceptor	PROPN
eurjchem-371	131	30	strengths	strength	NOUN
eurjchem-371	131	31	.	.	PUNCT
eurjchem-371	132	1	the	the	DET
eurjchem-371	132	2	compounds	compound	NOUN
eurjchem-371	132	3	used	use	VERB
eurjchem-371	132	4	,	,	PUNCT
eurjchem-371	132	5	together	together	ADV
eurjchem-371	132	6	narasimham	narasimham	PROPN
eurjchem-371	132	7	and	and	CCONJ
eurjchem-371	132	8	barhate	barhate	VERB
eurjchem-371	132	9	/	/	SYM
eurjchem-371	132	10	european	european	ADJ
eurjchem-371	132	11	journal	journal	PROPN
eurjchem-371	132	12	of	of	ADP
eurjchem-371	132	13	chemistry	chemistry	NOUN
eurjchem-371	132	14	2	2	NUM
eurjchem-371	132	15	(	(	PUNCT
eurjchem-371	132	16	1	1	NUM
eurjchem-371	132	17	)	)	PUNCT
eurjchem-371	132	18	(	(	PUNCT
eurjchem-371	132	19	2011	2011	NUM
eurjchem-371	132	20	)	)	PUNCT
eurjchem-371	132	21	36‐46	36‐46	NOUN
eurjchem-371	132	22	39	39	NUM
eurjchem-371	132	23	with	with	ADP
eurjchem-371	132	24	their	their	PRON
eurjchem-371	132	25	corresponding	correspond	VERB
eurjchem-371	132	26	log	log	NOUN
eurjchem-371	132	27	p	p	NOUN
eurjchem-371	132	28	values	value	NOUN
eurjchem-371	132	29	in	in	ADP
eurjchem-371	132	30	parentheses	parenthesis	NOUN
eurjchem-371	132	31	,	,	PUNCT
eurjchem-371	132	32	are	be	AUX
eurjchem-371	132	33	n‐methyl	n‐methyl	X
eurjchem-371	132	34	aniline	aniline	NOUN
eurjchem-371	132	35	(	(	PUNCT
eurjchem-371	132	36	1.66	1.66	NUM
eurjchem-371	132	37	)	)	PUNCT
eurjchem-371	132	38	,	,	PUNCT
eurjchem-371	132	39	sulphinide	sulphinide	PROPN
eurjchem-371	132	40	(	(	PUNCT
eurjchem-371	132	41	2.07	2.07	NUM
eurjchem-371	132	42	)	)	PUNCT
eurjchem-371	132	43	,	,	PUNCT
eurjchem-371	132	44	labetolol	labetolol	PROPN
eurjchem-371	132	45	(	(	PUNCT
eurjchem-371	132	46	2.65	2.65	NUM
eurjchem-371	132	47	)	)	PUNCT
eurjchem-371	132	48	,	,	PUNCT
eurjchem-371	132	49	4‐iodophenol	4‐iodophenol	NOUN
eurjchem-371	132	50	(	(	PUNCT
eurjchem-371	132	51	2.91	2.91	NUM
eurjchem-371	132	52	)	)	PUNCT
eurjchem-371	132	53	,	,	PUNCT
eurjchem-371	132	54	diltiazem	diltiazem	NOUN
eurjchem-371	132	55	(	(	PUNCT
eurjchem-371	132	56	3.38	3.38	NUM
eurjchem-371	132	57	)	)	PUNCT
eurjchem-371	132	58	,	,	PUNCT
eurjchem-371	132	59	triphenylene	triphenylene	NOUN
eurjchem-371	132	60	(	(	PUNCT
eurjchem-371	132	61	4.37	4.37	NUM
eurjchem-371	132	62	)	)	PUNCT
eurjchem-371	132	63	,	,	PUNCT
eurjchem-371	132	64	and	and	CCONJ
eurjchem-371	132	65	chloropromazine	chloropromazine	NOUN
eurjchem-371	132	66	(	(	PUNCT
eurjchem-371	132	67	5.35	5.35	NUM
eurjchem-371	132	68	)	)	PUNCT
eurjchem-371	132	69	.	.	PUNCT
eurjchem-371	133	1	table	table	NOUN
eurjchem-371	133	2	1	1	NUM
eurjchem-371	133	3	.	.	PUNCT
eurjchem-371	134	1	different	different	ADJ
eurjchem-371	134	2	octanol‐water	octanol‐water	NOUN
eurjchem-371	134	3	phase	phase	NOUN
eurjchem-371	134	4	ratio	ratio	NOUN
eurjchem-371	134	5	for	for	ADP
eurjchem-371	134	6	log	log	NOUN
eurjchem-371	134	7	p	p	PROPN
eurjchem-371	134	8	experimental	experimental	ADJ
eurjchem-371	134	9	design	design	NOUN
eurjchem-371	134	10	.	.	PUNCT
eurjchem-371	135	1	beaker	beaker	NOUN
eurjchem-371	135	2	octanol	octanol	PROPN
eurjchem-371	135	3	volume	volume	NOUN
eurjchem-371	135	4	(	(	PUNCT
eurjchem-371	135	5	first	first	ADJ
eurjchem-371	135	6	addition	addition	NOUN
eurjchem-371	135	7	is	be	AUX
eurjchem-371	135	8	always	always	ADV
eurjchem-371	135	9	manual	manual	ADJ
eurjchem-371	135	10	in	in	ADP
eurjchem-371	135	11	advance	advance	NOUN
eurjchem-371	135	12	and	and	CCONJ
eurjchem-371	135	13	sonicate	sonicate	VERB
eurjchem-371	135	14	for	for	ADP
eurjchem-371	135	15	30	30	NUM
eurjchem-371	135	16	to	to	PART
eurjchem-371	135	17	45	45	NUM
eurjchem-371	135	18	minutes	minute	NOUN
eurjchem-371	135	19	)	)	PUNCT
eurjchem-371	135	20	aqueous	aqueous	ADJ
eurjchem-371	135	21	volume	volume	NOUN
eurjchem-371	135	22	(	(	PUNCT
eurjchem-371	135	23	ml	ml	NOUN
eurjchem-371	135	24	)	)	PUNCT
eurjchem-371	135	25	1st	1st	ADJ
eurjchem-371	135	26	beaker	beaker	NOUN
eurjchem-371	135	27	0.5	0.5	NUM
eurjchem-371	135	28	1.0	1.0	NUM
eurjchem-371	135	29	3.5	3.5	NUM
eurjchem-371	135	30	10	10	NUM
eurjchem-371	135	31	2nd	2nd	ADJ
eurjchem-371	135	32	beaker	beaker	NOUN
eurjchem-371	135	33	0.25	0.25	NUM
eurjchem-371	135	34	0.25	0.25	NUM
eurjchem-371	135	35	0.25	0.25	NUM
eurjchem-371	135	36	10	10	NUM
eurjchem-371	135	37	3rd	3rd	ADJ
eurjchem-371	135	38	beaker	beaker	NOUN
eurjchem-371	135	39	0.5	0.5	NUM
eurjchem-371	135	40	0.5	0.5	NUM
eurjchem-371	135	41	1.0	1.0	NUM
eurjchem-371	135	42	10	10	NUM
eurjchem-371	135	43	a	a	DET
eurjchem-371	135	44	serveyor	serveyor	NOUN
eurjchem-371	135	45	hplc	hplc	NOUN
eurjchem-371	135	46	system	system	NOUN
eurjchem-371	135	47	(	(	PUNCT
eurjchem-371	135	48	thermo	thermo	NOUN
eurjchem-371	135	49	fisher	fisher	PROPN
eurjchem-371	135	50	,	,	PUNCT
eurjchem-371	135	51	usa	usa	PROPN
eurjchem-371	135	52	)	)	PUNCT
eurjchem-371	135	53	equipped	equip	VERB
eurjchem-371	135	54	with	with	ADP
eurjchem-371	135	55	quaternary	quaternary	ADJ
eurjchem-371	135	56	gradient	gradient	NOUN
eurjchem-371	135	57	pump	pump	NOUN
eurjchem-371	135	58	,	,	PUNCT
eurjchem-371	135	59	auto	auto	NOUN
eurjchem-371	135	60	sampler	sampler	NOUN
eurjchem-371	135	61	,	,	PUNCT
eurjchem-371	135	62	column	column	NOUN
eurjchem-371	135	63	oven	oven	NOUN
eurjchem-371	135	64	and	and	CCONJ
eurjchem-371	135	65	photodiode	photodiode	NOUN
eurjchem-371	135	66	array	array	NOUN
eurjchem-371	135	67	detector	detector	NOUN
eurjchem-371	135	68	(	(	PUNCT
eurjchem-371	135	69	pda	pda	NOUN
eurjchem-371	135	70	)	)	PUNCT
eurjchem-371	135	71	was	be	AUX
eurjchem-371	135	72	employed	employ	VERB
eurjchem-371	135	73	for	for	ADP
eurjchem-371	135	74	analysis	analysis	NOUN
eurjchem-371	135	75	.	.	PUNCT
eurjchem-371	136	1	chromatographic	chromatographic	ADJ
eurjchem-371	136	2	data	datum	NOUN
eurjchem-371	136	3	was	be	AUX
eurjchem-371	136	4	acquired	acquire	VERB
eurjchem-371	136	5	using	use	VERB
eurjchem-371	136	6	chromquest	chromqu	ADJ
eurjchem-371	136	7	4.2	4.2	NUM
eurjchem-371	136	8	software	software	NOUN
eurjchem-371	136	9	.	.	PUNCT
eurjchem-371	137	1	an	an	DET
eurjchem-371	137	2	x‐terra	x‐terra	PUNCT
eurjchem-371	137	3	c18	c18	NOUN
eurjchem-371	137	4	,	,	PUNCT
eurjchem-371	137	5	100×2.1	100×2.1	NUM
eurjchem-371	137	6	mm	mm	NOUN
eurjchem-371	137	7	,	,	PUNCT
eurjchem-371	137	8	5	5	NUM
eurjchem-371	137	9	µm	µm	NOUN
eurjchem-371	137	10	column	column	NOUN
eurjchem-371	137	11	was	be	AUX
eurjchem-371	137	12	used	use	VERB
eurjchem-371	137	13	for	for	ADP
eurjchem-371	137	14	separation	separation	NOUN
eurjchem-371	137	15	.	.	PUNCT
eurjchem-371	138	1	the	the	DET
eurjchem-371	138	2	mobile	mobile	ADJ
eurjchem-371	138	3	phase	phase	NOUN
eurjchem-371	138	4	consisting	consist	VERB
eurjchem-371	138	5	of	of	ADP
eurjchem-371	138	6	a	a	DET
eurjchem-371	138	7	:	:	PUNCT
eurjchem-371	138	8	buffer	buffer	NOUN
eurjchem-371	138	9	(	(	PUNCT
eurjchem-371	138	10	10	10	NUM
eurjchem-371	138	11	mm	mm	NOUN
eurjchem-371	138	12	ammonium	ammonium	NOUN
eurjchem-371	138	13	acetate	acetate	PROPN
eurjchem-371	138	14	ph=7.4	ph=7.4	PROPN
eurjchem-371	138	15	adjusted	adjust	VERB
eurjchem-371	138	16	with	with	ADP
eurjchem-371	138	17	ammonium	ammonium	NOUN
eurjchem-371	138	18	hydroxide	hydroxide	NOUN
eurjchem-371	138	19	)	)	PUNCT
eurjchem-371	138	20	and	and	CCONJ
eurjchem-371	138	21	b	b	X
eurjchem-371	138	22	:	:	PUNCT
eurjchem-371	138	23	a	a	DET
eurjchem-371	138	24	mixture	mixture	NOUN
eurjchem-371	138	25	of	of	ADP
eurjchem-371	138	26	90	90	NUM
eurjchem-371	138	27	%	%	NOUN
eurjchem-371	138	28	acetonitrile	acetonitrile	NOUN
eurjchem-371	138	29	and	and	CCONJ
eurjchem-371	138	30	10	10	NUM
eurjchem-371	138	31	%	%	NOUN
eurjchem-371	138	32	buffer	buffer	NOUN
eurjchem-371	138	33	with	with	ADP
eurjchem-371	138	34	a	a	DET
eurjchem-371	138	35	timed	time	VERB
eurjchem-371	138	36	gradient	gradient	NOUN
eurjchem-371	138	37	programme	programme	NOUN
eurjchem-371	138	38	was	be	AUX
eurjchem-371	138	39	used	use	VERB
eurjchem-371	138	40	.	.	PUNCT
eurjchem-371	139	1	the	the	DET
eurjchem-371	139	2	gradient	gradient	ADJ
eurjchem-371	139	3	condition	condition	NOUN
eurjchem-371	139	4	of	of	ADP
eurjchem-371	139	5	the	the	DET
eurjchem-371	139	6	mobile	mobile	ADJ
eurjchem-371	139	7	phase	phase	NOUN
eurjchem-371	139	8	was	be	AUX
eurjchem-371	139	9	:	:	PUNCT
eurjchem-371	139	10	0	0	NUM
eurjchem-371	139	11	min	min	NOUN
eurjchem-371	139	12	4	4	NUM
eurjchem-371	139	13	%	%	NOUN
eurjchem-371	139	14	solvent	solvent	PROPN
eurjchem-371	139	15	b	b	PROPN
eurjchem-371	139	16	,	,	PUNCT
eurjchem-371	139	17	16.0	16.0	NUM
eurjchem-371	139	18	min	min	NOUN
eurjchem-371	139	19	90	90	NUM
eurjchem-371	139	20	%	%	NOUN
eurjchem-371	139	21	solvent	solvent	PROPN
eurjchem-371	139	22	b	b	PROPN
eurjchem-371	139	23	,	,	PUNCT
eurjchem-371	139	24	18.2	18.2	NUM
eurjchem-371	139	25	min	min	NOUN
eurjchem-371	139	26	90	90	NUM
eurjchem-371	139	27	%	%	NOUN
eurjchem-371	139	28	solvent	solvent	PROPN
eurjchem-371	139	29	b	b	PROPN
eurjchem-371	139	30	,	,	PUNCT
eurjchem-371	139	31	18.9	18.9	NUM
eurjchem-371	139	32	min	min	NOUN
eurjchem-371	139	33	4	4	NUM
eurjchem-371	139	34	%	%	NOUN
eurjchem-371	139	35	solvent	solvent	NOUN
eurjchem-371	139	36	b	b	PROPN
eurjchem-371	139	37	and	and	CCONJ
eurjchem-371	139	38	25	25	NUM
eurjchem-371	139	39	min	min	NOUN
eurjchem-371	139	40	4	4	NUM
eurjchem-371	139	41	%	%	NOUN
eurjchem-371	139	42	solvent	solvent	NOUN
eurjchem-371	139	43	b.	b.	NOUN
eurjchem-371	140	1	the	the	DET
eurjchem-371	140	2	flow	flow	NOUN
eurjchem-371	140	3	rate	rate	NOUN
eurjchem-371	140	4	of	of	ADP
eurjchem-371	140	5	the	the	DET
eurjchem-371	140	6	mobile	mobile	ADJ
eurjchem-371	140	7	phase	phase	NOUN
eurjchem-371	140	8	was	be	AUX
eurjchem-371	140	9	0.5	0.5	NUM
eurjchem-371	140	10	ml	ml	NOUN
eurjchem-371	140	11	/	/	SYM
eurjchem-371	140	12	min	min	NOUN
eurjchem-371	140	13	with	with	ADP
eurjchem-371	140	14	detection	detection	NOUN
eurjchem-371	140	15	at	at	ADP
eurjchem-371	140	16	220	220	NUM
eurjchem-371	140	17	nm	nm	NOUN
eurjchem-371	140	18	.	.	PUNCT
eurjchem-371	141	1	the	the	DET
eurjchem-371	141	2	column	column	NOUN
eurjchem-371	141	3	temperature	temperature	NOUN
eurjchem-371	141	4	was	be	AUX
eurjchem-371	141	5	kept	keep	VERB
eurjchem-371	141	6	at	at	ADP
eurjchem-371	141	7	37	37	NUM
eurjchem-371	141	8	°	°	ADP
eurjchem-371	141	9	c	c	NOUN
eurjchem-371	141	10	and	and	CCONJ
eurjchem-371	141	11	the	the	DET
eurjchem-371	141	12	injection	injection	NOUN
eurjchem-371	141	13	volume	volume	NOUN
eurjchem-371	141	14	was	be	AUX
eurjchem-371	141	15	10	10	NUM
eurjchem-371	141	16	µl	µl	NOUN
eurjchem-371	141	17	.	.	PUNCT
eurjchem-371	142	1	this	this	DET
eurjchem-371	142	2	method	method	NOUN
eurjchem-371	142	3	is	be	AUX
eurjchem-371	142	4	applied	apply	VERB
eurjchem-371	142	5	for	for	ADP
eurjchem-371	142	6	the	the	DET
eurjchem-371	142	7	log	log	NOUN
eurjchem-371	142	8	p	p	NOUN
eurjchem-371	142	9	determination	determination	NOUN
eurjchem-371	142	10	of	of	ADP
eurjchem-371	142	11	all	all	DET
eurjchem-371	142	12	the	the	DET
eurjchem-371	142	13	selected	select	VERB
eurjchem-371	142	14	drugs	drug	NOUN
eurjchem-371	142	15	by	by	ADP
eurjchem-371	142	16	hplc	hplc	NOUN
eurjchem-371	142	17	.	.	PUNCT
eurjchem-371	143	1	six	six	NUM
eurjchem-371	143	2	replicate	replicate	ADJ
eurjchem-371	143	3	injections	injection	NOUN
eurjchem-371	143	4	were	be	AUX
eurjchem-371	143	5	made	make	VERB
eurjchem-371	143	6	for	for	SCONJ
eurjchem-371	143	7	standard	standard	ADJ
eurjchem-371	143	8	and	and	CCONJ
eurjchem-371	143	9	samples	sample	NOUN
eurjchem-371	143	10	were	be	AUX
eurjchem-371	143	11	injected	inject	VERB
eurjchem-371	143	12	in	in	ADP
eurjchem-371	143	13	duplicate	duplicate	NOUN
eurjchem-371	143	14	.	.	PUNCT
eurjchem-371	144	1	3	3	X
eurjchem-371	144	2	.	.	NOUN
eurjchem-371	144	3	results	result	NOUN
eurjchem-371	144	4	and	and	CCONJ
eurjchem-371	144	5	discussion	discussion	NOUN
eurjchem-371	144	6	3.1	3.1	NUM
eurjchem-371	144	7	.	.	PUNCT
eurjchem-371	145	1	dissociation	dissociation	NOUN
eurjchem-371	145	2	constant	constant	ADJ
eurjchem-371	145	3	3.1.1	3.1.1	NUM
eurjchem-371	145	4	.	.	PUNCT
eurjchem-371	146	1	potentiometry	potentiometry	VERB
eurjchem-371	146	2	the	the	DET
eurjchem-371	146	3	selected	select	VERB
eurjchem-371	146	4	compounds	compound	NOUN
eurjchem-371	146	5	(	(	PUNCT
eurjchem-371	146	6	figure	figure	NOUN
eurjchem-371	146	7	2	2	NUM
eurjchem-371	146	8	)	)	PUNCT
eurjchem-371	146	9	in	in	ADP
eurjchem-371	146	10	the	the	DET
eurjchem-371	146	11	present	present	ADJ
eurjchem-371	146	12	investigation	investigation	NOUN
eurjchem-371	146	13	differ	differ	VERB
eurjchem-371	146	14	in	in	ADP
eurjchem-371	146	15	acid	acid	ADJ
eurjchem-371	146	16	–	–	PUNCT
eurjchem-371	146	17	base	base	NOUN
eurjchem-371	146	18	properties	property	NOUN
eurjchem-371	146	19	representing	represent	VERB
eurjchem-371	146	20	a	a	DET
eurjchem-371	146	21	variety	variety	NOUN
eurjchem-371	146	22	of	of	ADP
eurjchem-371	146	23	proton‐binding	proton‐binde	VERB
eurjchem-371	146	24	sites	site	NOUN
eurjchem-371	146	25	in	in	ADP
eurjchem-371	146	26	both	both	CCONJ
eurjchem-371	146	27	the	the	DET
eurjchem-371	146	28	type	type	NOUN
eurjchem-371	146	29	and	and	CCONJ
eurjchem-371	146	30	the	the	DET
eurjchem-371	146	31	strength	strength	NOUN
eurjchem-371	146	32	.	.	PUNCT
eurjchem-371	147	1	there	there	PRON
eurjchem-371	147	2	are	be	VERB
eurjchem-371	147	3	monovalent	monovalent	NOUN
eurjchem-371	147	4	bases	basis	NOUN
eurjchem-371	147	5	(	(	PUNCT
eurjchem-371	147	6	all	all	DET
eurjchem-371	147	7	beta‐blockers	beta‐blocker	NOUN
eurjchem-371	147	8	and	and	CCONJ
eurjchem-371	147	9	pgl	pgl	NOUN
eurjchem-371	147	10	)	)	PUNCT
eurjchem-371	147	11	with	with	ADP
eurjchem-371	147	12	guanidine	guanidine	NOUN
eurjchem-371	147	13	(	(	PUNCT
eurjchem-371	147	14	aml	aml	PROPN
eurjchem-371	147	15	)	)	PUNCT
eurjchem-371	147	16	,	,	PUNCT
eurjchem-371	147	17	isopropyl	isopropyl	NOUN
eurjchem-371	147	18	amine	amine	NOUN
eurjchem-371	147	19	(	(	PUNCT
eurjchem-371	147	20	pro	pro	ADJ
eurjchem-371	147	21	,	,	PUNCT
eurjchem-371	147	22	atn	atn	PROPN
eurjchem-371	147	23	and	and	CCONJ
eurjchem-371	147	24	mt	mt	PROPN
eurjchem-371	147	25	)	)	PUNCT
eurjchem-371	147	26	,	,	PUNCT
eurjchem-371	147	27	primary	primary	ADJ
eurjchem-371	147	28	amine	amine	ADJ
eurjchem-371	147	29	(	(	PUNCT
eurjchem-371	147	30	ab	ab	NOUN
eurjchem-371	147	31	)	)	PUNCT
eurjchem-371	147	32	and	and	CCONJ
eurjchem-371	147	33	pyridine	pyridine	NOUN
eurjchem-371	147	34	nitrogen	nitrogen	NOUN
eurjchem-371	147	35	atom(s	atom(s	NOUN
eurjchem-371	147	36	)	)	PUNCT
eurjchem-371	147	37	(	(	PUNCT
eurjchem-371	147	38	pgl	pgl	NOUN
eurjchem-371	147	39	)	)	PUNCT
eurjchem-371	147	40	.	.	PUNCT
eurjchem-371	148	1	compounds	compound	VERB
eurjchem-371	148	2	glc	glc	PROPN
eurjchem-371	148	3	and	and	CCONJ
eurjchem-371	148	4	glz	glz	NOUN
eurjchem-371	148	5	are	be	AUX
eurjchem-371	148	6	acids	acid	NOUN
eurjchem-371	148	7	due	due	ADP
eurjchem-371	148	8	to	to	ADP
eurjchem-371	148	9	the	the	DET
eurjchem-371	148	10	‘	'	PUNCT
eurjchem-371	148	11	nh	nh	NOUN
eurjchem-371	148	12	group	group	NOUN
eurjchem-371	148	13	of	of	ADP
eurjchem-371	148	14	sulfonyl	sulfonyl	NOUN
eurjchem-371	148	15	urea	urea	NOUN
eurjchem-371	148	16	.	.	PUNCT
eurjchem-371	149	1	generally	generally	ADV
eurjchem-371	149	2	,	,	PUNCT
eurjchem-371	149	3	potentiometry	potentiometry	NOUN
eurjchem-371	149	4	in	in	ADP
eurjchem-371	149	5	aqueous	aqueous	ADJ
eurjchem-371	149	6	medium	medium	NOUN
eurjchem-371	149	7	is	be	AUX
eurjchem-371	149	8	the	the	DET
eurjchem-371	149	9	method	method	NOUN
eurjchem-371	149	10	of	of	ADP
eurjchem-371	149	11	choice	choice	NOUN
eurjchem-371	149	12	for	for	ADP
eurjchem-371	149	13	the	the	DET
eurjchem-371	149	14	pka	pka	PROPN
eurjchem-371	149	15	determination	determination	NOUN
eurjchem-371	149	16	for	for	ADP
eurjchem-371	149	17	molecules	molecule	NOUN
eurjchem-371	149	18	having	have	VERB
eurjchem-371	149	19	solubility	solubility	NOUN
eurjchem-371	149	20	higher	high	ADJ
eurjchem-371	149	21	than	than	ADP
eurjchem-371	149	22	0.8	0.8	NUM
eurjchem-371	149	23	mm	mm	NOUN
eurjchem-371	149	24	concentration	concentration	NOUN
eurjchem-371	149	25	in	in	ADP
eurjchem-371	149	26	the	the	DET
eurjchem-371	149	27	whole	whole	ADJ
eurjchem-371	149	28	ph	ph	ADJ
eurjchem-371	149	29	interval	interval	NOUN
eurjchem-371	149	30	of	of	ADP
eurjchem-371	149	31	the	the	DET
eurjchem-371	149	32	titration	titration	NOUN
eurjchem-371	149	33	.	.	PUNCT
eurjchem-371	150	1	out	out	ADP
eurjchem-371	150	2	of	of	ADP
eurjchem-371	150	3	all	all	DET
eurjchem-371	150	4	selected	select	VERB
eurjchem-371	150	5	compounds	compound	NOUN
eurjchem-371	150	6	,	,	PUNCT
eurjchem-371	150	7	only	only	ADV
eurjchem-371	150	8	3	3	NUM
eurjchem-371	150	9	compounds	compound	NOUN
eurjchem-371	150	10	whose	whose	DET
eurjchem-371	150	11	pka	pka	PROPN
eurjchem-371	150	12	values	value	NOUN
eurjchem-371	150	13	could	could	AUX
eurjchem-371	150	14	be	be	AUX
eurjchem-371	150	15	measured	measure	VERB
eurjchem-371	150	16	in	in	ADP
eurjchem-371	150	17	aqueous	aqueous	ADJ
eurjchem-371	150	18	medium	medium	NOUN
eurjchem-371	150	19	either	either	CCONJ
eurjchem-371	150	20	by	by	ADP
eurjchem-371	150	21	potentiometry	potentiometry	NOUN
eurjchem-371	150	22	(	(	PUNCT
eurjchem-371	150	23	pro	pro	X
eurjchem-371	150	24	and	and	CCONJ
eurjchem-371	150	25	mt	mt	PROPN
eurjchem-371	150	26	)	)	PUNCT
eurjchem-371	150	27	or	or	CCONJ
eurjchem-371	150	28	spectrophotometric	spectrophotometric	ADJ
eurjchem-371	150	29	titration	titration	NOUN
eurjchem-371	150	30	(	(	PUNCT
eurjchem-371	150	31	aml	aml	PROPN
eurjchem-371	150	32	)	)	PUNCT
eurjchem-371	150	33	.	.	PUNCT
eurjchem-371	151	1	these	these	DET
eurjchem-371	151	2	molecules	molecule	NOUN
eurjchem-371	151	3	are	be	AUX
eurjchem-371	151	4	considered	consider	VERB
eurjchem-371	151	5	“	"	PUNCT
eurjchem-371	151	6	water‐soluble	water‐soluble	ADJ
eurjchem-371	151	7	”	"	PUNCT
eurjchem-371	151	8	and	and	CCONJ
eurjchem-371	151	9	its	its	PRON
eurjchem-371	151	10	results	result	NOUN
eurjchem-371	151	11	are	be	AUX
eurjchem-371	151	12	utilised	utilise	VERB
eurjchem-371	151	13	to	to	PART
eurjchem-371	151	14	evaluate	evaluate	VERB
eurjchem-371	151	15	the	the	DET
eurjchem-371	151	16	accuracy	accuracy	NOUN
eurjchem-371	151	17	of	of	ADP
eurjchem-371	151	18	the	the	DET
eurjchem-371	151	19	results	result	NOUN
eurjchem-371	151	20	obtained	obtain	VERB
eurjchem-371	151	21	in	in	ADP
eurjchem-371	151	22	various	various	ADJ
eurjchem-371	151	23	co	co	NOUN
eurjchem-371	151	24	solvents	solvent	NOUN
eurjchem-371	151	25	by	by	ADP
eurjchem-371	151	26	extrapolation	extrapolation	NOUN
eurjchem-371	151	27	method	method	NOUN
eurjchem-371	151	28	.	.	PUNCT
eurjchem-371	152	1	all	all	DET
eurjchem-371	152	2	other	other	ADJ
eurjchem-371	152	3	compounds	compound	NOUN
eurjchem-371	152	4	selected	select	VERB
eurjchem-371	152	5	in	in	ADP
eurjchem-371	152	6	this	this	DET
eurjchem-371	152	7	study	study	NOUN
eurjchem-371	152	8	did	do	AUX
eurjchem-371	152	9	not	not	PART
eurjchem-371	152	10	fulfil	fulfil	VERB
eurjchem-371	152	11	the	the	DET
eurjchem-371	152	12	solubility	solubility	NOUN
eurjchem-371	152	13	criterion	criterion	NOUN
eurjchem-371	152	14	(	(	PUNCT
eurjchem-371	152	15	less	less	ADJ
eurjchem-371	152	16	than	than	ADP
eurjchem-371	152	17	0.8	0.8	NUM
eurjchem-371	152	18	µm	µm	NOUN
eurjchem-371	152	19	)	)	PUNCT
eurjchem-371	152	20	and	and	CCONJ
eurjchem-371	152	21	hence	hence	ADV
eurjchem-371	152	22	,	,	PUNCT
eurjchem-371	152	23	the	the	DET
eurjchem-371	152	24	apparent	apparent	ADJ
eurjchem-371	152	25	dissociation	dissociation	NOUN
eurjchem-371	152	26	constants	constant	NOUN
eurjchem-371	152	27	,	,	PUNCT
eurjchem-371	152	28	pska	pska	NOUN
eurjchem-371	152	29	values	value	NOUN
eurjchem-371	152	30	were	be	AUX
eurjchem-371	152	31	measured	measure	VERB
eurjchem-371	152	32	in	in	ADP
eurjchem-371	152	33	different	different	ADJ
eurjchem-371	152	34	methanol	methanol	NOUN
eurjchem-371	152	35	–	–	PUNCT
eurjchem-371	152	36	water	water	NOUN
eurjchem-371	152	37	,	,	PUNCT
eurjchem-371	152	38	ethanol‐water	ethanol‐water	NOUN
eurjchem-371	152	39	,	,	PUNCT
eurjchem-371	152	40	acetonitrile‐water	acetonitrile‐water	NOUN
eurjchem-371	152	41	and	and	CCONJ
eurjchem-371	152	42	1,4‐	1,4‐	NUM
eurjchem-371	152	43	dioxane‐water	dioxane‐water	NOUN
eurjchem-371	152	44	mixtures	mixture	NOUN
eurjchem-371	152	45	and	and	CCONJ
eurjchem-371	152	46	the	the	DET
eurjchem-371	152	47	corresponding	corresponding	ADJ
eurjchem-371	152	48	extrapolated	extrapolate	VERB
eurjchem-371	152	49	pka	pka	PROPN
eurjchem-371	152	50	value	value	NOUN
eurjchem-371	152	51	were	be	AUX
eurjchem-371	152	52	obtained	obtain	VERB
eurjchem-371	152	53	by	by	ADP
eurjchem-371	152	54	yasuda‐shedlovsky	yasuda‐shedlovsky	PROPN
eurjchem-371	152	55	(	(	PUNCT
eurjchem-371	152	56	ys	ys	NOUN
eurjchem-371	152	57	)	)	PUNCT
eurjchem-371	152	58	extrapolation	extrapolation	NOUN
eurjchem-371	152	59	to	to	ADP
eurjchem-371	152	60	zero	zero	NUM
eurjchem-371	152	61	co‐solvent	co‐solvent	ADJ
eurjchem-371	152	62	content	content	NOUN
eurjchem-371	152	63	.	.	PUNCT
eurjchem-371	153	1	the	the	DET
eurjchem-371	153	2	average	average	ADJ
eurjchem-371	153	3	pska	pska	NOUN
eurjchem-371	153	4	values	value	NOUN
eurjchem-371	153	5	and	and	CCONJ
eurjchem-371	153	6	the	the	DET
eurjchem-371	153	7	standard	standard	ADJ
eurjchem-371	153	8	deviations	deviation	NOUN
eurjchem-371	153	9	were	be	AUX
eurjchem-371	153	10	calculated	calculate	VERB
eurjchem-371	153	11	from	from	ADP
eurjchem-371	153	12	three	three	NUM
eurjchem-371	153	13	parallel	parallel	ADJ
eurjchem-371	153	14	titrations	titration	NOUN
eurjchem-371	153	15	at	at	ADP
eurjchem-371	153	16	each	each	DET
eurjchem-371	153	17	r‐value	r‐value	NOUN
eurjchem-371	153	18	.	.	PUNCT
eurjchem-371	154	1	the	the	DET
eurjchem-371	154	2	ionization	ionization	NOUN
eurjchem-371	154	3	ability	ability	NOUN
eurjchem-371	154	4	of	of	ADP
eurjchem-371	154	5	the	the	DET
eurjchem-371	154	6	molecules	molecule	NOUN
eurjchem-371	154	7	is	be	AUX
eurjchem-371	154	8	characterized	characterize	VERB
eurjchem-371	154	9	here	here	ADV
eurjchem-371	154	10	by	by	ADP
eurjchem-371	154	11	the	the	DET
eurjchem-371	154	12	dissociation	dissociation	NOUN
eurjchem-371	154	13	constant	constant	ADJ
eurjchem-371	154	14	(	(	PUNCT
eurjchem-371	154	15	pka	pka	NOUN
eurjchem-371	154	16	)	)	PUNCT
eurjchem-371	154	17	measured	measure	VERB
eurjchem-371	154	18	by	by	ADP
eurjchem-371	154	19	potentiometric	potentiometric	ADJ
eurjchem-371	154	20	and	and	CCONJ
eurjchem-371	154	21	spectrophotometric	spectrophotometric	ADJ
eurjchem-371	154	22	techniques	technique	NOUN
eurjchem-371	154	23	in	in	ADP
eurjchem-371	154	24	different	different	ADJ
eurjchem-371	154	25	co‐solvents	co‐solvent	NOUN
eurjchem-371	154	26	‐	‐	ADJ
eurjchem-371	154	27	water	water	NOUN
eurjchem-371	154	28	mixtures	mixture	NOUN
eurjchem-371	154	29	.	.	PUNCT
eurjchem-371	155	1	the	the	DET
eurjchem-371	155	2	obtained	obtain	VERB
eurjchem-371	155	3	results	result	NOUN
eurjchem-371	155	4	show	show	VERB
eurjchem-371	155	5	the	the	DET
eurjchem-371	155	6	good	good	ADJ
eurjchem-371	155	7	reproducibility	reproducibility	NOUN
eurjchem-371	155	8	of	of	ADP
eurjchem-371	155	9	potentiometric	potentiometric	ADJ
eurjchem-371	155	10	and	and	CCONJ
eurjchem-371	155	11	spectrophotometric	spectrophotometric	ADJ
eurjchem-371	155	12	pka	pka	PROPN
eurjchem-371	155	13	determination	determination	NOUN
eurjchem-371	155	14	in	in	ADP
eurjchem-371	155	15	all	all	DET
eurjchem-371	155	16	the	the	DET
eurjchem-371	155	17	selected	select	VERB
eurjchem-371	155	18	co	co	X
eurjchem-371	155	19	solvent‐water	solvent‐water	PROPN
eurjchem-371	155	20	mixtures	mixture	NOUN
eurjchem-371	155	21	.	.	PUNCT
eurjchem-371	156	1	the	the	DET
eurjchem-371	156	2	standard	standard	ADJ
eurjchem-371	156	3	deviation	deviation	NOUN
eurjchem-371	156	4	values	value	NOUN
eurjchem-371	156	5	varied	vary	VERB
eurjchem-371	156	6	between	between	ADP
eurjchem-371	156	7	0.01	0.01	NUM
eurjchem-371	156	8	and	and	CCONJ
eurjchem-371	156	9	0.15	0.15	NUM
eurjchem-371	156	10	.	.	PUNCT
eurjchem-371	157	1	from	from	ADP
eurjchem-371	157	2	the	the	DET
eurjchem-371	157	3	measured	measure	VERB
eurjchem-371	157	4	pska	pska	NOUN
eurjchem-371	157	5	values	value	NOUN
eurjchem-371	157	6	the	the	DET
eurjchem-371	157	7	aqueous	aqueous	ADJ
eurjchem-371	157	8	pka	pka	PROPN
eurjchem-371	157	9	can	can	AUX
eurjchem-371	157	10	be	be	AUX
eurjchem-371	157	11	obtained	obtain	VERB
eurjchem-371	157	12	by	by	ADP
eurjchem-371	157	13	extrapolation	extrapolation	NOUN
eurjchem-371	157	14	.	.	PUNCT
eurjchem-371	158	1	in	in	ADP
eurjchem-371	158	2	order	order	NOUN
eurjchem-371	158	3	to	to	PART
eurjchem-371	158	4	select	select	VERB
eurjchem-371	158	5	the	the	DET
eurjchem-371	158	6	best	good	ADJ
eurjchem-371	158	7	extrapolation	extrapolation	NOUN
eurjchem-371	158	8	procedure	procedure	NOUN
eurjchem-371	158	9	in	in	ADP
eurjchem-371	158	10	different	different	ADJ
eurjchem-371	158	11	co	co	NOUN
eurjchem-371	158	12	solvents	solvent	NOUN
eurjchem-371	158	13	,	,	PUNCT
eurjchem-371	158	14	we	we	PRON
eurjchem-371	158	15	compared	compare	VERB
eurjchem-371	158	16	the	the	DET
eurjchem-371	158	17	yasuda	yasuda	NOUN
eurjchem-371	158	18	–	–	PUNCT
eurjchem-371	158	19	shedlovsky	shedlovsky	ADV
eurjchem-371	158	20	(	(	PUNCT
eurjchem-371	158	21	ys	ys	NOUN
eurjchem-371	158	22	)	)	PUNCT
eurjchem-371	158	23	linear	linear	ADJ
eurjchem-371	158	24	relationships	relationship	NOUN
eurjchem-371	158	25	using	use	VERB
eurjchem-371	158	26	eq	eq	ADP
eurjchem-371	158	27	.	.	PROPN
eurjchem-371	158	28	2	2	X
eurjchem-371	158	29	.	.	X
eurjchem-371	158	30	results	result	NOUN
eurjchem-371	158	31	indicate	indicate	VERB
eurjchem-371	158	32	that	that	SCONJ
eurjchem-371	158	33	this	this	DET
eurjchem-371	158	34	method	method	NOUN
eurjchem-371	158	35	provide	provide	VERB
eurjchem-371	158	36	appropriate	appropriate	ADJ
eurjchem-371	158	37	pka	pka	PROPN
eurjchem-371	158	38	values	value	NOUN
eurjchem-371	158	39	in	in	ADP
eurjchem-371	158	40	the	the	DET
eurjchem-371	158	41	cases	case	NOUN
eurjchem-371	158	42	of	of	ADP
eurjchem-371	158	43	both	both	CCONJ
eurjchem-371	158	44	potentiometric	potentiometric	ADJ
eurjchem-371	158	45	and	and	CCONJ
eurjchem-371	158	46	uv	uv	NOUN
eurjchem-371	158	47	/	/	SYM
eurjchem-371	158	48	ph	ph	NOUN
eurjchem-371	158	49	techniques	technique	NOUN
eurjchem-371	158	50	.	.	PUNCT
eurjchem-371	159	1	table	table	NOUN
eurjchem-371	159	2	3	3	NUM
eurjchem-371	159	3	summarizes	summarize	NOUN
eurjchem-371	159	4	the	the	DET
eurjchem-371	159	5	different	different	ADJ
eurjchem-371	159	6	solvent	solvent	ADJ
eurjchem-371	159	7	weight	weight	NOUN
eurjchem-371	159	8	percent	percent	NOUN
eurjchem-371	159	9	range	range	NOUN
eurjchem-371	159	10	used	use	VERB
eurjchem-371	159	11	for	for	ADP
eurjchem-371	159	12	the	the	DET
eurjchem-371	159	13	titration	titration	NOUN
eurjchem-371	159	14	,	,	PUNCT
eurjchem-371	159	15	dielectric	dielectric	ADJ
eurjchem-371	159	16	constant	constant	ADJ
eurjchem-371	159	17	(	(	PUNCT
eurjchem-371	159	18	ε	ε	PROPN
eurjchem-371	159	19	)	)	PUNCT
eurjchem-371	159	20	,	,	PUNCT
eurjchem-371	159	21	regression	regression	NOUN
eurjchem-371	159	22	coefficient	coefficient	NOUN
eurjchem-371	159	23	(	(	PUNCT
eurjchem-371	159	24	r2	r2	PROPN
eurjchem-371	159	25	)	)	PUNCT
eurjchem-371	159	26	,	,	PUNCT
eurjchem-371	159	27	the	the	DET
eurjchem-371	159	28	number	number	NOUN
eurjchem-371	159	29	of	of	ADP
eurjchem-371	159	30	titrations	titration	NOUN
eurjchem-371	159	31	(	(	PUNCT
eurjchem-371	159	32	n	n	CCONJ
eurjchem-371	159	33	)	)	PUNCT
eurjchem-371	159	34	,	,	PUNCT
eurjchem-371	159	35	extrapolated	extrapolate	VERB
eurjchem-371	159	36	aqueous	aqueous	ADJ
eurjchem-371	159	37	pka	pka	PROPN
eurjchem-371	159	38	values	value	NOUN
eurjchem-371	159	39	and	and	CCONJ
eurjchem-371	159	40	the	the	DET
eurjchem-371	159	41	method	method	NOUN
eurjchem-371	159	42	of	of	ADP
eurjchem-371	159	43	titration	titration	NOUN
eurjchem-371	159	44	.	.	PUNCT
eurjchem-371	160	1	figure	figure	NOUN
eurjchem-371	160	2	2	2	NUM
eurjchem-371	160	3	.	.	PUNCT
eurjchem-371	161	1	(	(	PUNCT
eurjchem-371	161	2	a	a	X
eurjchem-371	161	3	)	)	PUNCT
eurjchem-371	161	4	amiloride	amiloride	ADJ
eurjchem-371	161	5	hydrochloride	hydrochloride	NOUN
eurjchem-371	161	6	(	(	PUNCT
eurjchem-371	161	7	aml	aml	PROPN
eurjchem-371	161	8	)	)	PUNCT
eurjchem-371	161	9	;	;	PUNCT
eurjchem-371	161	10	(	(	PUNCT
eurjchem-371	161	11	b	b	X
eurjchem-371	161	12	)	)	PUNCT
eurjchem-371	161	13	propranolol	propranolol	NOUN
eurjchem-371	161	14	hydrochloride	hydrochloride	NOUN
eurjchem-371	161	15	(	(	PUNCT
eurjchem-371	161	16	pro	pro	ADJ
eurjchem-371	161	17	)	)	PUNCT
eurjchem-371	161	18	;	;	PUNCT
eurjchem-371	161	19	(	(	PUNCT
eurjchem-371	161	20	c	c	X
eurjchem-371	161	21	)	)	PUNCT
eurjchem-371	161	22	atenolol	atenolol	PROPN
eurjchem-371	161	23	(	(	PUNCT
eurjchem-371	161	24	atn	atn	PROPN
eurjchem-371	161	25	)	)	PUNCT
eurjchem-371	161	26	;	;	PUNCT
eurjchem-371	161	27	(	(	PUNCT
eurjchem-371	161	28	d	d	X
eurjchem-371	161	29	)	)	PUNCT
eurjchem-371	161	30	metoprolol	metoprolol	PROPN
eurjchem-371	161	31	tartrate	tartrate	NOUN
eurjchem-371	161	32	(	(	PUNCT
eurjchem-371	161	33	mt	mt	PROPN
eurjchem-371	161	34	)	)	PUNCT
eurjchem-371	161	35	;	;	PUNCT
eurjchem-371	161	36	(	(	PUNCT
eurjchem-371	161	37	e	e	X
eurjchem-371	161	38	)	)	PUNCT
eurjchem-371	161	39	amlodipine	amlodipine	ADJ
eurjchem-371	161	40	besylate	besylate	NOUN
eurjchem-371	161	41	(	(	PUNCT
eurjchem-371	161	42	ab	ab	PROPN
eurjchem-371	161	43	)	)	PUNCT
eurjchem-371	161	44	;	;	PUNCT
eurjchem-371	161	45	(	(	PUNCT
eurjchem-371	161	46	f	f	X
eurjchem-371	161	47	)	)	PUNCT
eurjchem-371	161	48	gliclazide	gliclazide	NOUN
eurjchem-371	161	49	(	(	PUNCT
eurjchem-371	161	50	glc	glc	PROPN
eurjchem-371	161	51	)	)	PUNCT
eurjchem-371	161	52	;	;	PUNCT
eurjchem-371	161	53	(	(	PUNCT
eurjchem-371	161	54	g	g	NOUN
eurjchem-371	161	55	)	)	PUNCT
eurjchem-371	161	56	pioglitazone	pioglitazone	NOUN
eurjchem-371	161	57	(	(	PUNCT
eurjchem-371	161	58	pgl	pgl	NOUN
eurjchem-371	161	59	)	)	PUNCT
eurjchem-371	161	60	;	;	PUNCT
eurjchem-371	161	61	(	(	PUNCT
eurjchem-371	161	62	h	h	NOUN
eurjchem-371	161	63	)	)	PUNCT
eurjchem-371	161	64	glipizide	glipizide	NOUN
eurjchem-371	161	65	(	(	PUNCT
eurjchem-371	161	66	glz	glz	PROPN
eurjchem-371	161	67	)	)	PUNCT
eurjchem-371	161	68	and	and	CCONJ
eurjchem-371	161	69	(	(	PUNCT
eurjchem-371	161	70	i	i	NOUN
eurjchem-371	161	71	)	)	PUNCT
eurjchem-371	161	72	glibenclamide	glibenclamide	NOUN
eurjchem-371	161	73	(	(	PUNCT
eurjchem-371	161	74	glb	glb	NOUN
eurjchem-371	161	75	)	)	PUNCT
eurjchem-371	161	76	.	.	PUNCT
eurjchem-371	162	1	figure	figure	NOUN
eurjchem-371	162	2	3	3	NUM
eurjchem-371	162	3	and	and	CCONJ
eurjchem-371	162	4	4	4	NUM
eurjchem-371	162	5	represents	represent	VERB
eurjchem-371	162	6	the	the	DET
eurjchem-371	162	7	yasuda‐shedlovsky	yasuda‐shedlovsky	ADJ
eurjchem-371	162	8	trend	trend	NOUN
eurjchem-371	162	9	charts	chart	NOUN
eurjchem-371	162	10	for	for	ADP
eurjchem-371	162	11	beta	beta	ADJ
eurjchem-371	162	12	blockers	blocker	NOUN
eurjchem-371	162	13	and	and	CCONJ
eurjchem-371	162	14	anti‐diabetic	anti‐diabetic	ADJ
eurjchem-371	162	15	compounds	compound	NOUN
eurjchem-371	162	16	selected	select	VERB
eurjchem-371	162	17	in	in	ADP
eurjchem-371	162	18	this	this	DET
eurjchem-371	162	19	study	study	NOUN
eurjchem-371	162	20	.	.	PUNCT
eurjchem-371	163	1	it	it	PRON
eurjchem-371	163	2	can	can	AUX
eurjchem-371	163	3	be	be	AUX
eurjchem-371	163	4	seen	see	VERB
eurjchem-371	163	5	that	that	SCONJ
eurjchem-371	163	6	basic	basic	ADJ
eurjchem-371	163	7	functional	functional	ADJ
eurjchem-371	163	8	groups	group	NOUN
eurjchem-371	163	9	have	have	VERB
eurjchem-371	163	10	negative	negative	ADJ
eurjchem-371	163	11	slopes	slope	NOUN
eurjchem-371	163	12	and	and	CCONJ
eurjchem-371	163	13	produce	produce	VERB
eurjchem-371	163	14	straight	straight	ADJ
eurjchem-371	163	15	lines	line	NOUN
eurjchem-371	163	16	in	in	ADP
eurjchem-371	163	17	the	the	DET
eurjchem-371	163	18	total	total	ADJ
eurjchem-371	163	19	interval	interval	NOUN
eurjchem-371	163	20	.	.	PUNCT
eurjchem-371	164	1	the	the	DET
eurjchem-371	164	2	acids	acid	NOUN
eurjchem-371	164	3	have	have	VERB
eurjchem-371	164	4	positive	positive	ADJ
eurjchem-371	164	5	slopes	slope	NOUN
eurjchem-371	164	6	.	.	PUNCT
eurjchem-371	165	1	the	the	DET
eurjchem-371	165	2	linearity	linearity	NOUN
eurjchem-371	165	3	of	of	ADP
eurjchem-371	165	4	the	the	DET
eurjchem-371	165	5	plots	plot	NOUN
eurjchem-371	165	6	is	be	AUX
eurjchem-371	165	7	characterized	characterize	VERB
eurjchem-371	165	8	by	by	ADP
eurjchem-371	165	9	the	the	DET
eurjchem-371	165	10	regression	regression	NOUN
eurjchem-371	165	11	coefficients	coefficient	VERB
eurjchem-371	165	12	values	value	NOUN
eurjchem-371	165	13	which	which	PRON
eurjchem-371	165	14	indicate	indicate	VERB
eurjchem-371	165	15	significant	significant	ADJ
eurjchem-371	165	16	linear	linear	ADJ
eurjchem-371	165	17	correlation	correlation	NOUN
eurjchem-371	165	18	for	for	ADP
eurjchem-371	165	19	the	the	DET
eurjchem-371	165	20	molecules	molecule	NOUN
eurjchem-371	165	21	examined	examine	VERB
eurjchem-371	165	22	.	.	PUNCT
eurjchem-371	166	1	the	the	DET
eurjchem-371	166	2	average	average	NOUN
eurjchem-371	166	3	of	of	ADP
eurjchem-371	166	4	the	the	DET
eurjchem-371	166	5	r2	r2	PROPN
eurjchem-371	166	6	values	value	NOUN
eurjchem-371	166	7	is	be	AUX
eurjchem-371	166	8	0.9945	0.9945	NUM
eurjchem-371	166	9	.	.	PUNCT
eurjchem-371	167	1	the	the	DET
eurjchem-371	167	2	pka	pka	PROPN
eurjchem-371	167	3	results	result	VERB
eurjchem-371	167	4	in	in	ADP
eurjchem-371	167	5	table	table	NOUN
eurjchem-371	167	6	2	2	NUM
eurjchem-371	167	7	allow	allow	VERB
eurjchem-371	167	8	interpretation	interpretation	NOUN
eurjchem-371	167	9	of	of	ADP
eurjchem-371	167	10	the	the	DET
eurjchem-371	167	11	structure	structure	NOUN
eurjchem-371	167	12	–	–	PUNCT
eurjchem-371	167	13	property	property	NOUN
eurjchem-371	167	14	relationships	relationship	NOUN
eurjchem-371	167	15	(	(	PUNCT
eurjchem-371	167	16	spr	spr	INTJ
eurjchem-371	167	17	)	)	PUNCT
eurjchem-371	167	18	between	between	ADP
eurjchem-371	167	19	the	the	DET
eurjchem-371	167	20	basicity	basicity	NOUN
eurjchem-371	167	21	and	and	CCONJ
eurjchem-371	167	22	the	the	DET
eurjchem-371	167	23	chemical	chemical	NOUN
eurjchem-371	167	24	structure	structure	NOUN
eurjchem-371	167	25	of	of	ADP
eurjchem-371	167	26	the	the	DET
eurjchem-371	167	27	molecules	molecule	NOUN
eurjchem-371	167	28	.	.	PUNCT
eurjchem-371	168	1	in	in	ADP
eurjchem-371	168	2	compound	compound	NOUN
eurjchem-371	168	3	aml	aml	PROPN
eurjchem-371	168	4	,	,	PUNCT
eurjchem-371	168	5	the	the	DET
eurjchem-371	168	6	central	central	ADJ
eurjchem-371	168	7	element	element	NOUN
eurjchem-371	168	8	of	of	ADP
eurjchem-371	168	9	the	the	DET
eurjchem-371	168	10	structure	structure	NOUN
eurjchem-371	168	11	is	be	AUX
eurjchem-371	168	12	a	a	DET
eurjchem-371	168	13	guanidine	guanidine	NOUN
eurjchem-371	168	14	,	,	PUNCT
eurjchem-371	168	15	the	the	DET
eurjchem-371	168	16	n	n	PRON
eurjchem-371	168	17	atom	atom	NOUN
eurjchem-371	168	18	of	of	ADP
eurjchem-371	168	19	which	which	PRON
eurjchem-371	168	20	is	be	AUX
eurjchem-371	168	21	the	the	DET
eurjchem-371	168	22	proton‐binding	proton‐binde	VERB
eurjchem-371	168	23	site	site	NOUN
eurjchem-371	168	24	which	which	PRON
eurjchem-371	168	25	is	be	AUX
eurjchem-371	168	26	an	an	DET
eurjchem-371	168	27	integral	integral	ADJ
eurjchem-371	168	28	part	part	NOUN
eurjchem-371	168	29	of	of	ADP
eurjchem-371	168	30	the	the	DET
eurjchem-371	168	31	conjugated	conjugated	ADJ
eurjchem-371	168	32	double	double	ADJ
eurjchem-371	168	33	bond	bond	NOUN
eurjchem-371	168	34	,	,	PUNCT
eurjchem-371	168	35	while	while	SCONJ
eurjchem-371	168	36	in	in	ADP
eurjchem-371	168	37	compounds	compound	NOUN
eurjchem-371	168	38	pro	pro	ADJ
eurjchem-371	168	39	,	,	PUNCT
eurjchem-371	168	40	atn	atn	PROPN
eurjchem-371	168	41	and	and	CCONJ
eurjchem-371	168	42	mt	mt	PROPN
eurjchem-371	168	43	,	,	PUNCT
eurjchem-371	168	44	the	the	DET
eurjchem-371	168	45	n	n	PRON
eurjchem-371	168	46	atom	atom	NOUN
eurjchem-371	168	47	of	of	ADP
eurjchem-371	168	48	isopropyl	isopropyl	NOUN
eurjchem-371	168	49	amino	amino	NOUN
eurjchem-371	168	50	group	group	NOUN
eurjchem-371	168	51	is	be	AUX
eurjchem-371	168	52	the	the	DET
eurjchem-371	168	53	proton‐binding	proton‐binde	VERB
eurjchem-371	168	54	site	site	NOUN
eurjchem-371	168	55	which	which	PRON
eurjchem-371	168	56	is	be	AUX
eurjchem-371	168	57	not	not	PART
eurjchem-371	168	58	a	a	DET
eurjchem-371	168	59	part	part	NOUN
eurjchem-371	168	60	of	of	ADP
eurjchem-371	168	61	conjugation	conjugation	NOUN
eurjchem-371	168	62	.	.	PUNCT
eurjchem-371	169	1	isopropyl	isopropyl	PROPN
eurjchem-371	169	2	group	group	NOUN
eurjchem-371	169	3	increases	increase	VERB
eurjchem-371	169	4	electron	electron	NOUN
eurjchem-371	169	5	density	density	NOUN
eurjchem-371	169	6	on	on	ADP
eurjchem-371	169	7	n	n	DET
eurjchem-371	169	8	atom	atom	NOUN
eurjchem-371	169	9	due	due	ADP
eurjchem-371	169	10	to	to	ADP
eurjchem-371	169	11	+	+	PROPN
eurjchem-371	169	12	i	i	PRON
eurjchem-371	169	13	(	(	PUNCT
eurjchem-371	169	14	inductive	inductive	ADJ
eurjchem-371	169	15	)	)	PUNCT
eurjchem-371	169	16	effect	effect	NOUN
eurjchem-371	169	17	and	and	CCONJ
eurjchem-371	169	18	hence	hence	ADV
eurjchem-371	169	19	imparts	impart	VERB
eurjchem-371	169	20	the	the	DET
eurjchem-371	169	21	basicity	basicity	NOUN
eurjchem-371	169	22	.	.	PUNCT
eurjchem-371	170	1	in	in	ADP
eurjchem-371	170	2	case	case	NOUN
eurjchem-371	170	3	of	of	ADP
eurjchem-371	170	4	compounds	compound	NOUN
eurjchem-371	170	5	‘	'	PUNCT
eurjchem-371	170	6	ab	ab	NOUN
eurjchem-371	170	7	’	'	PUNCT
eurjchem-371	170	8	and	and	CCONJ
eurjchem-371	170	9	‘	'	PUNCT
eurjchem-371	170	10	pio	pio	ADJ
eurjchem-371	170	11	’	'	PUNCT
eurjchem-371	170	12	,	,	PUNCT
eurjchem-371	170	13	primary	primary	ADJ
eurjchem-371	170	14	amine	amine	NOUN
eurjchem-371	170	15	and	and	CCONJ
eurjchem-371	170	16	pyridine	pyridine	NOUN
eurjchem-371	170	17	group	group	NOUN
eurjchem-371	170	18	,	,	PUNCT
eurjchem-371	170	19	respectively	respectively	ADV
eurjchem-371	170	20	,	,	PUNCT
eurjchem-371	170	21	makes	make	VERB
eurjchem-371	170	22	the	the	DET
eurjchem-371	170	23	molecule	molecule	NOUN
eurjchem-371	170	24	comparatively	comparatively	ADV
eurjchem-371	170	25	weak	weak	ADJ
eurjchem-371	170	26	base	base	NOUN
eurjchem-371	170	27	.	.	PUNCT
eurjchem-371	171	1	40	40	NUM
eurjchem-371	171	2	narasimham	narasimham	PROPN
eurjchem-371	171	3	and	and	CCONJ
eurjchem-371	171	4	barhate	barhate	VERB
eurjchem-371	171	5	/	/	SYM
eurjchem-371	171	6	european	european	ADJ
eurjchem-371	171	7	journal	journal	PROPN
eurjchem-371	171	8	of	of	ADP
eurjchem-371	171	9	chemistry	chemistry	NOUN
eurjchem-371	171	10	2	2	NUM
eurjchem-371	171	11	(	(	PUNCT
eurjchem-371	171	12	1	1	NUM
eurjchem-371	171	13	)	)	PUNCT
eurjchem-371	171	14	(	(	PUNCT
eurjchem-371	171	15	2011	2011	NUM
eurjchem-371	171	16	)	)	PUNCT
eurjchem-371	171	17	36‐46	36‐46	NUM
eurjchem-371	171	18	table	table	NOUN
eurjchem-371	171	19	2	2	NUM
eurjchem-371	171	20	.	.	PUNCT
eurjchem-371	172	1	pka	pka	PROPN
eurjchem-371	172	2	values	value	NOUN
eurjchem-371	172	3	by	by	ADP
eurjchem-371	172	4	yasuda‐shedlovsky	yasuda‐shedlovsky	ADJ
eurjchem-371	172	5	extrapolation	extrapolation	NOUN
eurjchem-371	172	6	in	in	ADP
eurjchem-371	172	7	different	different	ADJ
eurjchem-371	172	8	co‐solvents	co‐solvent	NOUN
eurjchem-371	172	9	.	.	PUNCT
eurjchem-371	173	1	compound	compound	NOUN
eurjchem-371	173	2	co‐solvent	co‐solvent	ADJ
eurjchem-371	173	3	wt	wt	NUM
eurjchem-371	173	4	%	%	NOUN
eurjchem-371	173	5	ε	ε	PROPN
eurjchem-371	173	6	pska	pska	NOUN
eurjchem-371	173	7	+	+	CCONJ
eurjchem-371	173	8	log	log	NOUN
eurjchem-371	173	9	[	[	X
eurjchem-371	173	10	h2o	h2o	X
eurjchem-371	173	11	]	]	X
eurjchem-371	173	12	=	=	SYM
eurjchem-371	173	13	a	a	X
eurjchem-371	173	14	/	/	SYM
eurjchem-371	173	15	ε	ε	PROPN
eurjchem-371	173	16	+	+	CCONJ
eurjchem-371	173	17	b	b	PROPN
eurjchem-371	173	18	r2	r2	PROPN
eurjchem-371	173	19	n	n	PROPN
eurjchem-371	173	20	pka	pka	PROPN
eurjchem-371	173	21	±	±	PROPN
eurjchem-371	173	22	s.d	s.d	PROPN
eurjchem-371	173	23	.	.	PUNCT
eurjchem-371	174	1	(	(	PUNCT
eurjchem-371	174	2	ys	ys	NOUN
eurjchem-371	174	3	)	)	PUNCT
eurjchem-371	174	4	literature	literature	NOUN
eurjchem-371	174	5	valuesa	valuesa	NOUN
eurjchem-371	174	6	method	method	VERB
eurjchem-371	174	7	a	a	DET
eurjchem-371	174	8	b	b	PROPN
eurjchem-371	174	9	amiloride	amiloride	ADJ
eurjchem-371	174	10	hydrochloride	hydrochloride	NOUN
eurjchem-371	174	11	methanol	methanol	NOUN
eurjchem-371	174	12	20‐50	20‐50	NUM
eurjchem-371	174	13	56‐70	56‐70	NUM
eurjchem-371	174	14	‐20.7	‐20.7	NOUN
eurjchem-371	175	1	10.7	10.7	NUM
eurjchem-371	175	2	0.9989	0.9989	NUM
eurjchem-371	175	3	4	4	NUM
eurjchem-371	175	4	8.72	8.72	NUM
eurjchem-371	175	5	±	±	NUM
eurjchem-371	175	6	0.05	0.05	NUM
eurjchem-371	175	7	8.7±0.1	8.7±0.1	NUM
eurjchem-371	175	8	potentiometric	potentiometric	ADJ
eurjchem-371	175	9	20‐50	20‐50	NUM
eurjchem-371	175	10	56‐70	56‐70	NUM
eurjchem-371	175	11	‐61.1	‐61.1	NUM
eurjchem-371	175	12	11.4	11.4	NUM
eurjchem-371	175	13	0.9883	0.9883	NUM
eurjchem-371	175	14	4	4	NUM
eurjchem-371	175	15	8.82	8.82	NUM
eurjchem-371	175	16	±	±	NUM
eurjchem-371	175	17	0.02	0.02	NUM
eurjchem-371	175	18	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	175	19	ethanol	ethanol	NOUN
eurjchem-371	175	20	30‐60	30‐60	NUM
eurjchem-371	175	21	43‐60	43‐60	NUM
eurjchem-371	175	22	‐25.8	‐25.8	ADP
eurjchem-371	175	23	10.5	10.5	NUM
eurjchem-371	175	24	0.9797	0.9797	NUM
eurjchem-371	175	25	4	4	NUM
eurjchem-371	175	26	8.47	8.47	NUM
eurjchem-371	175	27	±	±	NUM
eurjchem-371	175	28	0.05	0.05	NUM
eurjchem-371	175	29	potentiometric	potentiometric	ADJ
eurjchem-371	175	30	30‐60	30‐60	NUM
eurjchem-371	175	31	43‐60	43‐60	NUM
eurjchem-371	175	32	‐21.1	‐21.1	NUM
eurjchem-371	175	33	10.6	10.6	NUM
eurjchem-371	175	34	0.9836	0.9836	NUM
eurjchem-371	175	35	4	4	NUM
eurjchem-371	175	36	8.55	8.55	NUM
eurjchem-371	175	37	±	±	NUM
eurjchem-371	175	38	0.01	0.01	NUM
eurjchem-371	175	39	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	175	40	acetonitrile	acetonitrile	ADJ
eurjchem-371	175	41	20‐60	20‐60	NUM
eurjchem-371	175	42	51‐70	51‐70	NUM
eurjchem-371	175	43	41.9	41.9	NUM
eurjchem-371	175	44	9.7	9.7	NUM
eurjchem-371	175	45	0.9999	0.9999	NUM
eurjchem-371	175	46	3	3	NUM
eurjchem-371	175	47	8.51	8.51	NUM
eurjchem-371	175	48	±	±	NUM
eurjchem-371	175	49	0.07	0.07	NUM
eurjchem-371	175	50	potentiometric	potentiometric	ADJ
eurjchem-371	175	51	10‐60	10‐60	NUM
eurjchem-371	175	52	51‐74	51‐74	NOUN
eurjchem-371	175	53	69.2	69.2	NUM
eurjchem-371	175	54	9.4	9.4	NUM
eurjchem-371	175	55	0.9835	0.9835	NUM
eurjchem-371	175	56	4	4	NUM
eurjchem-371	175	57	8.55	8.55	NUM
eurjchem-371	175	58	±	±	NUM
eurjchem-371	175	59	0.03	0.03	NUM
eurjchem-371	175	60	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	175	61	1,4‐dioxane	1,4‐dioxane	NOUN
eurjchem-371	175	62	30‐50	30‐50	NUM
eurjchem-371	175	63	34‐52	34‐52	NUM
eurjchem-371	175	64	10.2	10.2	NUM
eurjchem-371	175	65	10.2	10.2	NUM
eurjchem-371	175	66	0.9880	0.9880	NUM
eurjchem-371	175	67	3	3	NUM
eurjchem-371	175	68	8.64	8.64	NUM
eurjchem-371	175	69	±	±	NUM
eurjchem-371	175	70	0.02	0.02	NUM
eurjchem-371	175	71	potentiometric	potentiometric	ADJ
eurjchem-371	175	72	10‐50	10‐50	NUM
eurjchem-371	175	73	34‐70	34‐70	PROPN
eurjchem-371	175	74	19.3	19.3	NUM
eurjchem-371	175	75	10.2	10.2	NUM
eurjchem-371	175	76	0.9920	0.9920	NUM
eurjchem-371	175	77	4	4	NUM
eurjchem-371	175	78	8.70	8.70	NUM
eurjchem-371	175	79	±	±	NUM
eurjchem-371	175	80	0.03	0.03	NUM
eurjchem-371	175	81	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	175	82	3	3	NUM
eurjchem-371	175	83	8.71	8.71	NUM
eurjchem-371	175	84	±	±	NUM
eurjchem-371	175	85	0.004	0.004	NUM
eurjchem-371	175	86	uv‐ph	uv‐ph	ADJ
eurjchem-371	175	87	(	(	PUNCT
eurjchem-371	175	88	aqueous	aqueous	ADJ
eurjchem-371	175	89	)	)	PUNCT
eurjchem-371	175	90	proopranolol	proopranolol	PROPN
eurjchem-371	175	91	hydrochloride	hydrochloride	NOUN
eurjchem-371	175	92	methanol	methanol	NOUN
eurjchem-371	175	93	10‐50	10‐50	NUM
eurjchem-371	175	94	56‐74	56‐74	NOUN
eurjchem-371	175	95	‐146.3	‐146.3	NOUN
eurjchem-371	175	96	12.9	12.9	NUM
eurjchem-371	175	97	0.9982	0.9982	NUM
eurjchem-371	175	98	5	5	NUM
eurjchem-371	175	99	9.31	9.31	NUM
eurjchem-371	175	100	±	±	NUM
eurjchem-371	175	101	0.05	0.05	NUM
eurjchem-371	175	102	9.53±0.1	9.53±0.1	NOUN
eurjchem-371	175	103	potentiometric	potentiometric	NOUN
eurjchem-371	175	104	10‐48	10‐48	NUM
eurjchem-371	175	105	57‐74	57‐74	NUM
eurjchem-371	175	106	‐188.1	‐188.1	NOUN
eurjchem-371	175	107	13.6	13.6	NUM
eurjchem-371	175	108	0.9919	0.9919	NUM
eurjchem-371	175	109	5	5	NUM
eurjchem-371	175	110	9.41	9.41	NUM
eurjchem-371	175	111	±	±	NUM
eurjchem-371	175	112	0.03	0.03	NUM
eurjchem-371	175	113	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	175	114	ethanol	ethanol	NOUN
eurjchem-371	175	115	10‐50	10‐50	NUM
eurjchem-371	175	116	49‐73	49‐73	NUM
eurjchem-371	175	117	‐179.9	‐179.9	VERB
eurjchem-371	175	118	13.5	13.5	NUM
eurjchem-371	175	119	0.9985	0.9985	NUM
eurjchem-371	175	120	5	5	NUM
eurjchem-371	175	121	9.45	9.45	NUM
eurjchem-371	175	122	±	±	NUM
eurjchem-371	175	123	0.08	0.08	NUM
eurjchem-371	175	124	potentiometric	potentiometric	ADJ
eurjchem-371	175	125	10‐60	10‐60	NUM
eurjchem-371	175	126	43‐72	43‐72	NOUN
eurjchem-371	175	127	‐115.4	‐115.4	NOUN
eurjchem-371	175	128	12.5	12.5	NUM
eurjchem-371	175	129	0.9999	0.9999	NUM
eurjchem-371	175	130	3	3	NUM
eurjchem-371	175	131	9.28	9.28	NUM
eurjchem-371	175	132	±	±	NUM
eurjchem-371	175	133	0.20	0.20	NUM
eurjchem-371	175	134	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	175	135	acetonitrile	acetonitrile	NOUN
eurjchem-371	175	136	10‐35	10‐35	NUM
eurjchem-371	175	137	63‐75	63‐75	NUM
eurjchem-371	175	138	‐223.7	‐223.7	NOUN
eurjchem-371	175	139	14.0	14.0	NUM
eurjchem-371	175	140	0.9993	0.9993	NUM
eurjchem-371	175	141	4	4	NUM
eurjchem-371	175	142	9.42	9.42	NUM
eurjchem-371	175	143	±	±	NUM
eurjchem-371	175	144	0.03	0.03	NUM
eurjchem-371	175	145	potentiometric	potentiometric	ADJ
eurjchem-371	175	146	10‐49	10‐49	NUM
eurjchem-371	175	147	55‐74	55‐74	NUM
eurjchem-371	175	148	‐107.1	‐107.1	NOUN
eurjchem-371	175	149	12.4	12.4	NUM
eurjchem-371	175	150	0.9960	0.9960	NUM
eurjchem-371	175	151	3	3	NUM
eurjchem-371	175	152	9.26	9.26	NUM
eurjchem-371	175	153	±	±	NUM
eurjchem-371	175	154	0.12	0.12	NUM
eurjchem-371	175	155	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	175	156	1,4‐dioxane	1,4‐dioxane	NOUN
eurjchem-371	175	157	10‐45	10‐45	NUM
eurjchem-371	175	158	38‐70	38‐70	NUM
eurjchem-371	175	159	‐41.1	‐41.1	NOUN
eurjchem-371	175	160	11.7	11.7	NUM
eurjchem-371	175	161	0.9968	0.9968	NUM
eurjchem-371	175	162	4	4	NUM
eurjchem-371	175	163	9.44	9.44	NUM
eurjchem-371	175	164	±	±	NUM
eurjchem-371	175	165	0.04	0.04	NUM
eurjchem-371	175	166	potentiometric	potentiometric	ADJ
eurjchem-371	175	167	10‐60	10‐60	NUM
eurjchem-371	175	168	25‐69	25‐69	NUM
eurjchem-371	175	169	‐12.7	‐12.7	NUM
eurjchem-371	175	170	11.2	11.2	NUM
eurjchem-371	175	171	0.9891	0.9891	NUM
eurjchem-371	175	172	5	5	NUM
eurjchem-371	175	173	9.30	9.30	NUM
eurjchem-371	175	174	±	±	NUM
eurjchem-371	175	175	0.03	0.03	NUM
eurjchem-371	175	176	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	175	177	3	3	NUM
eurjchem-371	175	178	9.46	9.46	NUM
eurjchem-371	175	179	±	±	NUM
eurjchem-371	175	180	0.02	0.02	NUM
eurjchem-371	175	181	ph	ph	NOUN
eurjchem-371	175	182	metry	metry	NOUN
eurjchem-371	175	183	‐	‐	ADJ
eurjchem-371	175	184	aqueous	aqueous	ADJ
eurjchem-371	175	185	atenolol	atenolol	NOUN
eurjchem-371	175	186	methanol	methanol	NOUN
eurjchem-371	175	187	20‐60	20‐60	NUM
eurjchem-371	175	188	52‐70	52‐70	NUM
eurjchem-371	175	189	‐138.6	‐138.6	NOUN
eurjchem-371	175	190	12.9	12.9	NUM
eurjchem-371	175	191	0.9990	0.9990	NUM
eurjchem-371	175	192	5	5	NUM
eurjchem-371	175	193	9.37	9.37	NUM
eurjchem-371	175	194	±	±	NUM
eurjchem-371	175	195	0.04	0.04	NUM
eurjchem-371	175	196	9.48±0.1	9.48±0.1	NUM
eurjchem-371	175	197	potentiometric	potentiometric	ADJ
eurjchem-371	175	198	20‐60	20‐60	NUM
eurjchem-371	175	199	52‐70	52‐70	X
eurjchem-371	175	200	‐184.8	‐184.8	VERB
eurjchem-371	175	201	13.6	13.6	NUM
eurjchem-371	175	202	0.9970	0.9970	NUM
eurjchem-371	175	203	5	5	NUM
eurjchem-371	175	204	9.51	9.51	NUM
eurjchem-371	175	205	±	±	NUM
eurjchem-371	175	206	0.07	0.07	NUM
eurjchem-371	175	207	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	175	208	ethanol	ethanol	NOUN
eurjchem-371	175	209	20‐43	20‐43	NUM
eurjchem-371	176	1	53‐67	53‐67	NUM
eurjchem-371	176	2	‐207.1	‐207.1	NOUN
eurjchem-371	176	3	14.0	14.0	NUM
eurjchem-371	176	4	0.9996	0.9996	NUM
eurjchem-371	176	5	5	5	NUM
eurjchem-371	176	6	9.63	9.63	NUM
eurjchem-371	176	7	±	±	NUM
eurjchem-371	176	8	0.06	0.06	NUM
eurjchem-371	176	9	potentiometric	potentiometric	ADJ
eurjchem-371	176	10	10‐49	10‐49	NUM
eurjchem-371	176	11	50‐73	50‐73	NOUN
eurjchem-371	176	12	‐114.4	‐114.4	NOUN
eurjchem-371	176	13	12.6	12.6	NUM
eurjchem-371	176	14	0.9808	0.9808	NUM
eurjchem-371	176	15	4	4	NUM
eurjchem-371	176	16	9.41	9.41	NUM
eurjchem-371	176	17	±	±	NUM
eurjchem-371	176	18	0.05	0.05	NUM
eurjchem-371	176	19	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	176	20	acetonitrile	acetonitrile	NOUN
eurjchem-371	176	21	20‐35	20‐35	NUM
eurjchem-371	176	22	63‐71	63‐71	NOUN
eurjchem-371	176	23	‐222.5	‐222.5	VERB
eurjchem-371	176	24	14.1	14.1	NUM
eurjchem-371	176	25	0.9948	0.9948	NUM
eurjchem-371	176	26	4	4	NUM
eurjchem-371	176	27	9.50	9.50	NUM
eurjchem-371	176	28	±	±	NUM
eurjchem-371	176	29	0.03	0.03	NUM
eurjchem-371	176	30	potentiometric	potentiometric	ADJ
eurjchem-371	176	31	10‐60	10‐60	NUM
eurjchem-371	176	32	51‐75	51‐75	X
eurjchem-371	176	33	‐57.7	‐57.7	NUM
eurjchem-371	176	34	12.0	12.0	NUM
eurjchem-371	176	35	0.9745	0.9745	NUM
eurjchem-371	176	36	4	4	NUM
eurjchem-371	176	37	9.52	9.52	NUM
eurjchem-371	176	38	±	±	NUM
eurjchem-371	176	39	0.03	0.03	NUM
eurjchem-371	176	40	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	176	41	1,4‐dioxane	1,4‐dioxane	NOUN
eurjchem-371	176	42	20‐50	20‐50	NUM
eurjchem-371	176	43	34‐61	34‐61	NUM
eurjchem-371	176	44	‐30.3	‐30.3	ADP
eurjchem-371	176	45	11.6	11.6	NUM
eurjchem-371	176	46	0.9996	0.9996	NUM
eurjchem-371	176	47	5	5	NUM
eurjchem-371	176	48	9.43	9.43	NUM
eurjchem-371	176	49	±	±	NUM
eurjchem-371	176	50	0.04	0.04	NUM
eurjchem-371	176	51	potentiometric	potentiometric	ADJ
eurjchem-371	176	52	10‐60	10‐60	NUM
eurjchem-371	176	53	26‐70	26‐70	NUM
eurjchem-371	176	54	‐13.3	‐13.3	VERB
eurjchem-371	176	55	11.4	11.4	NUM
eurjchem-371	176	56	0.9815	0.9815	NUM
eurjchem-371	176	57	5	5	NUM
eurjchem-371	176	58	9.53	9.53	NUM
eurjchem-371	176	59	±	±	NUM
eurjchem-371	176	60	0.02	0.02	NUM
eurjchem-371	176	61	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	176	62	metoprolol	metoprolol	NOUN
eurjchem-371	176	63	tartrate	tartrate	NOUN
eurjchem-371	176	64	methanol	methanol	NOUN
eurjchem-371	176	65	10‐40	10‐40	PROPN
eurjchem-371	176	66	61‐74	61‐74	PROPN
eurjchem-371	176	67	‐163.2	‐163.2	PROPN
eurjchem-371	176	68	13.2	13.2	NUM
eurjchem-371	176	69	0.9986	0.9986	NUM
eurjchem-371	176	70	4	4	NUM
eurjchem-371	176	71	9.35	9.35	NUM
eurjchem-371	176	72	±	±	NUM
eurjchem-371	176	73	0.04	0.04	NUM
eurjchem-371	176	74	9.51±0.1	9.51±0.1	NOUN
eurjchem-371	176	75	potentiometric	potentiometric	ADJ
eurjchem-371	176	76	ethanol	ethanol	NOUN
eurjchem-371	176	77	7‐50	7‐50	NUM
eurjchem-371	176	78	49‐74	49‐74	NUM
eurjchem-371	176	79	‐183.7	‐183.7	NOUN
eurjchem-371	176	80	13.6	13.6	NUM
eurjchem-371	176	81	0.9994	0.9994	NUM
eurjchem-371	176	82	5	5	NUM
eurjchem-371	176	83	9.53	9.53	NUM
eurjchem-371	176	84	±	±	NUM
eurjchem-371	176	85	0.09	0.09	NUM
eurjchem-371	176	86	potentiometric	potentiometric	ADJ
eurjchem-371	176	87	acetonitrile	acetonitrile	NOUN
eurjchem-371	176	88	6‐35	6‐35	NUM
eurjchem-371	176	89	63‐76	63‐76	NOUN
eurjchem-371	176	90	‐216.6	‐216.6	PROPN
eurjchem-371	176	91	13.9	13.9	NUM
eurjchem-371	176	92	0.9989	0.9989	NUM
eurjchem-371	176	93	4	4	NUM
eurjchem-371	176	94	9.43	9.43	NUM
eurjchem-371	176	95	±	±	NUM
eurjchem-371	176	96	0.01	0.01	NUM
eurjchem-371	176	97	potentiometric	potentiometric	ADJ
eurjchem-371	176	98	1,4‐dioxane	1,4‐dioxane	NOUN
eurjchem-371	176	99	10‐45	10‐45	NUM
eurjchem-371	176	100	38‐70	38‐70	PROPN
eurjchem-371	176	101	‐7.7	‐7.7	PROPN
eurjchem-371	176	102	11.2	11.2	NUM
eurjchem-371	176	103	0.9637	0.9637	NUM
eurjchem-371	176	104	4	4	NUM
eurjchem-371	176	105	9.36	9.36	NUM
eurjchem-371	176	106	±	±	NUM
eurjchem-371	176	107	0.01	0.01	NUM
eurjchem-371	176	108	potentiometric	potentiometric	ADJ
eurjchem-371	176	109	3	3	NUM
eurjchem-371	176	110	9.51	9.51	NUM
eurjchem-371	176	111	±	±	NUM
eurjchem-371	176	112	0.02	0.02	NUM
eurjchem-371	176	113	ph	ph	NOUN
eurjchem-371	176	114	metry	metry	NOUN
eurjchem-371	176	115	‐	‐	ADJ
eurjchem-371	176	116	aqueous	aqueous	ADJ
eurjchem-371	176	117	amlodipine	amlodipine	NOUN
eurjchem-371	176	118	besylate	besylate	ADJ
eurjchem-371	176	119	methanol	methanol	NOUN
eurjchem-371	176	120	21‐62	21‐62	NUM
eurjchem-371	176	121	50‐70	50‐70	NUM
eurjchem-371	176	122	‐108.7	‐108.7	NOUN
eurjchem-371	176	123	12.3	12.3	NUM
eurjchem-371	176	124	0.9993	0.9993	NUM
eurjchem-371	176	125	5	5	NUM
eurjchem-371	176	126	9.13	9.13	NUM
eurjchem-371	176	127	±	±	NUM
eurjchem-371	176	128	0.02	0.02	NUM
eurjchem-371	176	129	9.2±0.2	9.2±0.2	NUM
eurjchem-371	176	130	potentiometric	potentiometric	ADJ
eurjchem-371	176	131	ethanol	ethanol	NOUN
eurjchem-371	176	132	21‐39	21‐39	NOUN
eurjchem-371	176	133	55‐66	55‐66	NOUN
eurjchem-371	176	134	‐199.4	‐199.4	VERB
eurjchem-371	176	135	13.6	13.6	NUM
eurjchem-371	176	136	0.9988	0.9988	NUM
eurjchem-371	176	137	3	3	NUM
eurjchem-371	176	138	9.29	9.29	NUM
eurjchem-371	176	139	±	±	NUM
eurjchem-371	176	140	0.03	0.03	NUM
eurjchem-371	176	141	potentiometric	potentiometric	ADJ
eurjchem-371	176	142	acetonitrile	acetonitrile	NOUN
eurjchem-371	176	143	21‐31	21‐31	X
eurjchem-371	176	144	65‐70	65‐70	NUM
eurjchem-371	176	145	‐387.7	‐387.7	PROPN
eurjchem-371	176	146	16.2	16.2	NUM
eurjchem-371	176	147	0.9914	0.9914	NUM
eurjchem-371	176	148	3	3	NUM
eurjchem-371	176	149	9.48	9.48	NUM
eurjchem-371	176	150	±	±	NUM
eurjchem-371	176	151	0.01	0.01	NUM
eurjchem-371	176	152	potentiometric	potentiometric	ADJ
eurjchem-371	176	153	1,4‐dioxane	1,4‐dioxane	NUM
eurjchem-371	176	154	21‐51	21‐51	NUM
eurjchem-371	176	155	32‐60	32‐60	NUM
eurjchem-371	176	156	‐34.6	‐34.6	NUM
eurjchem-371	176	157	11.5	11.5	NUM
eurjchem-371	176	158	0.9993	0.9993	NUM
eurjchem-371	176	159	4	4	NUM
eurjchem-371	176	160	9.30	9.30	NUM
eurjchem-371	176	161	±	±	NUM
eurjchem-371	176	162	0.03	0.03	NUM
eurjchem-371	176	163	potentiometric	potentiometric	ADJ
eurjchem-371	176	164	pioglitazone	pioglitazone	NOUN
eurjchem-371	176	165	methanol	methanol	NOUN
eurjchem-371	176	166	37‐59	37‐59	PUNCT
eurjchem-371	176	167	53‐63	53‐63	NUM
eurjchem-371	176	168	‐174.7	‐174.7	NOUN
eurjchem-371	176	169	9.3	9.3	NUM
eurjchem-371	176	170	0.9981	0.9981	NUM
eurjchem-371	176	171	4	4	NUM
eurjchem-371	176	172	5.37	5.37	NUM
eurjchem-371	176	173	±	±	NUM
eurjchem-371	176	174	0.04	0.04	NUM
eurjchem-371	176	175	5.59±0.2	5.59±0.2	NUM
eurjchem-371	176	176	potentiometric	potentiometric	ADJ
eurjchem-371	176	177	ethanol	ethanol	NOUN
eurjchem-371	176	178	34‐56	34‐56	NOUN
eurjchem-371	176	179	46‐59	46‐59	NOUN
eurjchem-371	177	1	‐192.1	‐192.1	ADJ
eurjchem-371	177	2	9.7	9.7	NUM
eurjchem-371	177	3	0.9989	0.9989	NUM
eurjchem-371	177	4	3	3	NUM
eurjchem-371	177	5	5.56	5.56	NUM
eurjchem-371	177	6	±	±	NUM
eurjchem-371	177	7	0.05	0.05	NUM
eurjchem-371	177	8	potentiometric	potentiometric	ADJ
eurjchem-371	177	9	acetonitrile	acetonitrile	NOUN
eurjchem-371	177	10	31‐52	31‐52	NUM
eurjchem-371	177	11	55‐66	55‐66	NOUN
eurjchem-371	177	12	‐131.0	‐131.0	PROPN
eurjchem-371	177	13	8.8	8.8	NUM
eurjchem-371	177	14	0.9949	0.9949	NUM
eurjchem-371	177	15	3	3	NUM
eurjchem-371	177	16	5.38	5.38	NUM
eurjchem-371	177	17	±	±	NUM
eurjchem-371	177	18	0.04	0.04	NUM
eurjchem-371	177	19	potentiometric	potentiometric	ADJ
eurjchem-371	177	20	1,4‐dioxane	1,4‐dioxane	NOUN
eurjchem-371	177	21	30‐50	30‐50	NUM
eurjchem-371	177	22	34‐52	34‐52	NUM
eurjchem-371	177	23	‐19.4	‐19.4	ADP
eurjchem-371	177	24	6.6	6.6	NUM
eurjchem-371	177	25	0.9971	0.9971	NUM
eurjchem-371	177	26	3	3	NUM
eurjchem-371	177	27	4.74	4.74	NUM
eurjchem-371	177	28	±	±	NUM
eurjchem-371	177	29	0.06	0.06	NUM
eurjchem-371	177	30	potentiometric	potentiometric	ADJ
eurjchem-371	177	31	gliclazide	gliclazide	NOUN
eurjchem-371	177	32	methanol	methanol	NOUN
eurjchem-371	177	33	20‐60	20‐60	NUM
eurjchem-371	177	34	52‐70	52‐70	NUM
eurjchem-371	177	35	25.8	25.8	NUM
eurjchem-371	177	36	7.0	7.0	NUM
eurjchem-371	177	37	0.9996	0.9996	NUM
eurjchem-371	177	38	4	4	NUM
eurjchem-371	177	39	5.58	5.58	NUM
eurjchem-371	177	40	±	±	NUM
eurjchem-371	177	41	0.01	0.01	NUM
eurjchem-371	177	42	5.54±0.2	5.54±0.2	NUM
eurjchem-371	177	43	potentiometric	potentiometric	ADJ
eurjchem-371	177	44	10‐53	10‐53	NOUN
eurjchem-371	177	45	56‐75	56‐75	NUM
eurjchem-371	178	1	32.8	32.8	NUM
eurjchem-371	178	2	7.0	7.0	NUM
eurjchem-371	178	3	0.9909	0.9909	NUM
eurjchem-371	178	4	5	5	NUM
eurjchem-371	178	5	5.63	5.63	NUM
eurjchem-371	178	6	±	±	NUM
eurjchem-371	178	7	0.01	0.01	NUM
eurjchem-371	178	8	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	178	9	ethanol	ethanol	NOUN
eurjchem-371	178	10	20‐60	20‐60	NOUN
eurjchem-371	178	11	43‐67	43‐67	NOUN
eurjchem-371	178	12	11.8	11.8	NUM
eurjchem-371	178	13	7.2	7.2	NUM
eurjchem-371	178	14	0.9996	0.9996	NUM
eurjchem-371	178	15	4	4	NUM
eurjchem-371	178	16	5.63	5.63	NUM
eurjchem-371	178	17	±	±	NUM
eurjchem-371	178	18	0.01	0.01	NUM
eurjchem-371	178	19	potentiometric	potentiometric	ADJ
eurjchem-371	178	20	10‐53	10‐53	PROPN
eurjchem-371	178	21	48‐73	48‐73	PROPN
eurjchem-371	178	22	28.3	28.3	NUM
eurjchem-371	178	23	7.1	7.1	NUM
eurjchem-371	178	24	0.9997	0.9997	NUM
eurjchem-371	178	25	3	3	NUM
eurjchem-371	178	26	5.70	5.70	NUM
eurjchem-371	178	27	±	±	NUM
eurjchem-371	178	28	0.01	0.01	NUM
eurjchem-371	178	29	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	178	30	acetonitrile	acetonitrile	NOUN
eurjchem-371	178	31	11‐60	11‐60	NUM
eurjchem-371	178	32	51‐74	51‐74	NUM
eurjchem-371	178	33	177.8	177.8	NUM
eurjchem-371	178	34	5.0	5.0	NUM
eurjchem-371	178	35	0.9980	0.9980	NUM
eurjchem-371	178	36	4	4	NUM
eurjchem-371	178	37	5.58	5.58	NUM
eurjchem-371	178	38	±	±	NUM
eurjchem-371	178	39	0.06	0.06	NUM
eurjchem-371	178	40	potentiometric	potentiometric	ADJ
eurjchem-371	178	41	21‐53	21‐53	NOUN
eurjchem-371	178	42	54‐70	54‐70	NUM
eurjchem-371	178	43	111.3	111.3	NUM
eurjchem-371	178	44	6.0	6.0	NUM
eurjchem-371	178	45	0.9728	0.9728	NUM
eurjchem-371	178	46	3	3	NUM
eurjchem-371	178	47	5.64	5.64	NUM
eurjchem-371	178	48	±	±	NUM
eurjchem-371	178	49	0.08	0.08	NUM
eurjchem-371	178	50	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	178	51	1,4‐dioxane	1,4‐dioxane	NUM
eurjchem-371	178	52	20‐60	20‐60	NUM
eurjchem-371	178	53	25‐61	25‐61	NUM
eurjchem-371	178	54	50.6	50.6	NUM
eurjchem-371	178	55	6.6	6.6	NUM
eurjchem-371	178	56	0.9882	0.9882	NUM
eurjchem-371	178	57	5	5	NUM
eurjchem-371	178	58	5.48	5.48	NUM
eurjchem-371	178	59	±	±	NUM
eurjchem-371	178	60	0.05	0.05	NUM
eurjchem-371	178	61	potentiometric	potentiometric	ADJ
eurjchem-371	178	62	10‐52	10‐52	NUM
eurjchem-371	178	63	32‐70	32‐70	NUM
eurjchem-371	178	64	69.9	69.9	NUM
eurjchem-371	178	65	6.4	6.4	NUM
eurjchem-371	178	66	0.9956	0.9956	NUM
eurjchem-371	178	67	5	5	NUM
eurjchem-371	178	68	5.58	5.58	NUM
eurjchem-371	178	69	±	±	NUM
eurjchem-371	178	70	0.07	0.07	NUM
eurjchem-371	178	71	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	178	72	glipizide	glipizide	NOUN
eurjchem-371	178	73	methanol	methanol	NOUN
eurjchem-371	178	74	20‐60	20‐60	NUM
eurjchem-371	178	75	52‐70	52‐70	NUM
eurjchem-371	178	76	110.2	110.2	NUM
eurjchem-371	178	77	5.5	5.5	NUM
eurjchem-371	178	78	0.9985	0.9985	NUM
eurjchem-371	178	79	4	4	NUM
eurjchem-371	178	80	5.19	5.19	NUM
eurjchem-371	178	81	±	±	NUM
eurjchem-371	178	82	0.01	0.01	NUM
eurjchem-371	178	83	5.16±0.3	5.16±0.3	NUM
eurjchem-371	178	84	potentiometric	potentiometric	ADJ
eurjchem-371	178	85	ethanol	ethanol	NOUN
eurjchem-371	178	86	30‐60	30‐60	NUM
eurjchem-371	178	87	43‐60	43‐60	NUM
eurjchem-371	178	88	36.3	36.3	NUM
eurjchem-371	178	89	6.8	6.8	NUM
eurjchem-371	178	90	0.9961	0.9961	NUM
eurjchem-371	178	91	3	3	NUM
eurjchem-371	178	92	5.49	5.49	NUM
eurjchem-371	178	93	±	±	NUM
eurjchem-371	178	94	0.05	0.05	NUM
eurjchem-371	178	95	potentiometric	potentiometric	ADJ
eurjchem-371	178	96	acetonitrile	acetonitrile	NOUN
eurjchem-371	178	97	12‐50	12‐50	NUM
eurjchem-371	178	98	55‐74	55‐74	NUM
eurjchem-371	178	99	110.0	110.0	NUM
eurjchem-371	178	100	5.7	5.7	NUM
eurjchem-371	178	101	0.9853	0.9853	NUM
eurjchem-371	178	102	4	4	NUM
eurjchem-371	178	103	5.42	5.42	NUM
eurjchem-371	178	104	±	±	NUM
eurjchem-371	178	105	0.03	0.03	NUM
eurjchem-371	178	106	potentiometric	potentiometric	NOUN
eurjchem-371	178	107	1,4‐dioxane	1,4‐dioxane	NUM
eurjchem-371	178	108	27‐50	27‐50	NUM
eurjchem-371	178	109	34‐55	34‐55	NUM
eurjchem-371	178	110	94.3	94.3	NUM
eurjchem-371	178	111	5.4	5.4	NUM
eurjchem-371	178	112	0.9988	0.9988	NUM
eurjchem-371	178	113	4	4	NUM
eurjchem-371	178	114	4.89	4.89	NUM
eurjchem-371	178	115	±	±	NUM
eurjchem-371	178	116	0.15	0.15	NUM
eurjchem-371	178	117	potentiometric	potentiometric	ADJ
eurjchem-371	178	118	a	a	DET
eurjchem-371	178	119	ref	ref	NOUN
eurjchem-371	178	120	[	[	X
eurjchem-371	178	121	30	30	NUM
eurjchem-371	178	122	]	]	PUNCT
eurjchem-371	178	123	.	.	PUNCT
eurjchem-371	179	1	in	in	ADP
eurjchem-371	179	2	case	case	NOUN
eurjchem-371	179	3	of	of	ADP
eurjchem-371	179	4	glc	glc	PROPN
eurjchem-371	179	5	and	and	CCONJ
eurjchem-371	179	6	glz	glz	PROPN
eurjchem-371	179	7	,	,	PUNCT
eurjchem-371	179	8	the	the	DET
eurjchem-371	179	9	ionisable	ionisable	ADJ
eurjchem-371	179	10	‘	'	PUNCT
eurjchem-371	179	11	‐nh	‐nh	NOUN
eurjchem-371	179	12	’	'	PUNCT
eurjchem-371	179	13	of	of	ADP
eurjchem-371	179	14	sulfonyl	sulfonyl	ADJ
eurjchem-371	179	15	urea	urea	NOUN
eurjchem-371	179	16	moiety	moiety	NOUN
eurjchem-371	179	17	makes	make	VERB
eurjchem-371	179	18	the	the	DET
eurjchem-371	179	19	molecule	molecule	NOUN
eurjchem-371	179	20	acidic	acidic	ADJ
eurjchem-371	179	21	due	due	ADP
eurjchem-371	179	22	to	to	ADP
eurjchem-371	179	23	–	–	PUNCT
eurjchem-371	179	24	e	e	X
eurjchem-371	179	25	(	(	PUNCT
eurjchem-371	179	26	electron	electron	NOUN
eurjchem-371	179	27	with	with	ADP
eurjchem-371	179	28	drawing	drawing	NOUN
eurjchem-371	179	29	)	)	PUNCT
eurjchem-371	179	30	effect	effect	NOUN
eurjchem-371	179	31	of	of	ADP
eurjchem-371	179	32	sulfonyl	sulfonyl	NOUN
eurjchem-371	179	33	group	group	NOUN
eurjchem-371	179	34	attached	attach	VERB
eurjchem-371	179	35	to	to	ADP
eurjchem-371	179	36	‘	'	PUNCT
eurjchem-371	179	37	‐nh	‐nh	NOUN
eurjchem-371	179	38	’	'	PUNCT
eurjchem-371	179	39	of	of	ADP
eurjchem-371	179	40	urea	urea	PROPN
eurjchem-371	179	41	group	group	NOUN
eurjchem-371	179	42	.	.	PUNCT
eurjchem-371	180	1	a	a	DET
eurjchem-371	180	2	donor	donor	NOUN
eurjchem-371	180	3	number	number	NOUN
eurjchem-371	180	4	or	or	CCONJ
eurjchem-371	180	5	dn	dn	NOUN
eurjchem-371	180	6	is	be	AUX
eurjchem-371	180	7	a	a	DET
eurjchem-371	180	8	qualitative	qualitative	ADJ
eurjchem-371	180	9	measure	measure	NOUN
eurjchem-371	180	10	of	of	ADP
eurjchem-371	180	11	lewis	lewis	PROPN
eurjchem-371	180	12	basicity	basicity	PROPN
eurjchem-371	180	13	.	.	PUNCT
eurjchem-371	181	1	a	a	DET
eurjchem-371	181	2	donor	donor	NOUN
eurjchem-371	181	3	number	number	NOUN
eurjchem-371	181	4	is	be	AUX
eurjchem-371	181	5	defined	define	VERB
eurjchem-371	181	6	as	as	ADP
eurjchem-371	181	7	the	the	DET
eurjchem-371	181	8	negative	negative	ADJ
eurjchem-371	181	9	enthalpy	enthalpy	NOUN
eurjchem-371	181	10	value	value	NOUN
eurjchem-371	181	11	for	for	ADP
eurjchem-371	181	12	the	the	DET
eurjchem-371	181	13	1:1	1:1	NUM
eurjchem-371	181	14	adduct	adduct	NOUN
eurjchem-371	181	15	formation	formation	NOUN
eurjchem-371	181	16	between	between	ADP
eurjchem-371	181	17	a	a	DET
eurjchem-371	181	18	lewis	lewis	NOUN
eurjchem-371	181	19	base	base	NOUN
eurjchem-371	181	20	and	and	CCONJ
eurjchem-371	181	21	the	the	DET
eurjchem-371	181	22	standard	standard	PROPN
eurjchem-371	181	23	lewis	lewis	PROPN
eurjchem-371	181	24	acid	acid	PROPN
eurjchem-371	181	25	.	.	PUNCT
eurjchem-371	182	1	the	the	DET
eurjchem-371	182	2	units	unit	NOUN
eurjchem-371	182	3	are	be	AUX
eurjchem-371	182	4	kilocalories	kilocalorie	NOUN
eurjchem-371	182	5	per	per	ADP
eurjchem-371	182	6	mole	mole	NOUN
eurjchem-371	182	7	for	for	ADP
eurjchem-371	182	8	historical	historical	ADJ
eurjchem-371	182	9	reasons	reason	NOUN
eurjchem-371	182	10	[	[	X
eurjchem-371	182	11	31	31	NUM
eurjchem-371	182	12	]	]	PUNCT
eurjchem-371	182	13	.	.	PUNCT
eurjchem-371	183	1	the	the	DET
eurjchem-371	183	2	donor	donor	NOUN
eurjchem-371	183	3	number	number	NOUN
eurjchem-371	183	4	is	be	AUX
eurjchem-371	183	5	a	a	DET
eurjchem-371	183	6	measure	measure	NOUN
eurjchem-371	183	7	of	of	ADP
eurjchem-371	183	8	the	the	DET
eurjchem-371	183	9	ability	ability	NOUN
eurjchem-371	183	10	of	of	ADP
eurjchem-371	183	11	a	a	DET
eurjchem-371	183	12	solvent	solvent	NOUN
eurjchem-371	183	13	to	to	AUX
eurjchem-371	183	14	solvate	solvate	VERB
eurjchem-371	183	15	cations	cation	NOUN
eurjchem-371	183	16	and	and	CCONJ
eurjchem-371	183	17	lewis	lewis	PROPN
eurjchem-371	183	18	acids	acid	NOUN
eurjchem-371	183	19	.	.	PUNCT
eurjchem-371	184	1	the	the	DET
eurjchem-371	184	2	method	method	NOUN
eurjchem-371	184	3	was	be	AUX
eurjchem-371	184	4	developed	develop	VERB
eurjchem-371	184	5	by	by	ADP
eurjchem-371	184	6	v.	v.	ADP
eurjchem-371	184	7	gutmann	gutmann	PROPN
eurjchem-371	185	1	[	[	X
eurjchem-371	185	2	32	32	NUM
eurjchem-371	185	3	]	]	PUNCT
eurjchem-371	185	4	.	.	PUNCT
eurjchem-371	186	1	likewise	likewise	ADV
eurjchem-371	186	2	lewis	lewis	PROPN
eurjchem-371	186	3	acids	acid	NOUN
eurjchem-371	186	4	are	be	AUX
eurjchem-371	186	5	characterized	characterize	VERB
eurjchem-371	186	6	by	by	ADP
eurjchem-371	186	7	acceptor	acceptor	NOUN
eurjchem-371	186	8	numbers	number	NOUN
eurjchem-371	186	9	.	.	PUNCT
eurjchem-371	187	1	the	the	DET
eurjchem-371	187	2	dielectric	dielectric	ADJ
eurjchem-371	187	3	constants	constant	NOUN
eurjchem-371	187	4	of	of	ADP
eurjchem-371	187	5	all	all	DET
eurjchem-371	187	6	the	the	DET
eurjchem-371	187	7	selected	select	VERB
eurjchem-371	187	8	co	co	NOUN
eurjchem-371	187	9	solvents	solvent	NOUN
eurjchem-371	187	10	in	in	ADP
eurjchem-371	187	11	the	the	DET
eurjchem-371	187	12	present	present	ADJ
eurjchem-371	187	13	study	study	NOUN
eurjchem-371	187	14	are	be	AUX
eurjchem-371	187	15	lower	low	ADJ
eurjchem-371	187	16	than	than	ADP
eurjchem-371	187	17	that	that	PRON
eurjchem-371	187	18	of	of	ADP
eurjchem-371	187	19	water	water	NOUN
eurjchem-371	187	20	,	,	PUNCT
eurjchem-371	187	21	which	which	PRON
eurjchem-371	187	22	affects	affect	VERB
eurjchem-371	187	23	the	the	DET
eurjchem-371	187	24	ionization	ionization	NOUN
eurjchem-371	187	25	equilibria	equilibrium	NOUN
eurjchem-371	187	26	.	.	PUNCT
eurjchem-371	188	1	a	a	DET
eurjchem-371	188	2	solvent	solvent	NOUN
eurjchem-371	188	3	will	will	AUX
eurjchem-371	188	4	be	be	AUX
eurjchem-371	188	5	more	more	ADV
eurjchem-371	188	6	likely	likely	ADJ
eurjchem-371	188	7	to	to	PART
eurjchem-371	188	8	promote	promote	VERB
eurjchem-371	188	9	ionization	ionization	NOUN
eurjchem-371	188	10	of	of	ADP
eurjchem-371	188	11	a	a	DET
eurjchem-371	188	12	dissolved	dissolve	VERB
eurjchem-371	188	13	acidic	acidic	ADJ
eurjchem-371	188	14	molecule	molecule	NOUN
eurjchem-371	188	15	in	in	ADP
eurjchem-371	188	16	the	the	DET
eurjchem-371	188	17	following	follow	VERB
eurjchem-371	188	18	circumstances	circumstance	NOUN
eurjchem-371	188	19	[	[	X
eurjchem-371	188	20	33	33	NUM
eurjchem-371	188	21	]	]	PUNCT
eurjchem-371	188	22	.	.	PUNCT
eurjchem-371	189	1			X
eurjchem-371	189	2	a	a	DET
eurjchem-371	189	3	protic	protic	ADJ
eurjchem-371	189	4	solvent	solvent	NOUN
eurjchem-371	189	5	can	can	AUX
eurjchem-371	189	6	form	form	VERB
eurjchem-371	189	7	hydrogen	hydrogen	NOUN
eurjchem-371	189	8	bonds	bond	NOUN
eurjchem-371	189	9	and	and	CCONJ
eurjchem-371	189	10	will	will	AUX
eurjchem-371	189	11	promote	promote	VERB
eurjchem-371	189	12	ionisation	ionisation	NOUN
eurjchem-371	189	13	.	.	PUNCT
eurjchem-371	190	1			X
eurjchem-371	190	2	a	a	DET
eurjchem-371	190	3	solvent	solvent	NOUN
eurjchem-371	190	4	with	with	ADP
eurjchem-371	190	5	a	a	DET
eurjchem-371	190	6	high	high	ADJ
eurjchem-371	190	7	donor	donor	NOUN
eurjchem-371	190	8	number	number	NOUN
eurjchem-371	190	9	is	be	AUX
eurjchem-371	190	10	a	a	DET
eurjchem-371	190	11	strong	strong	ADJ
eurjchem-371	190	12	lewis	lewis	PROPN
eurjchem-371	190	13	base	base	NOUN
eurjchem-371	190	14	.	.	PUNCT
eurjchem-371	191	1			X
eurjchem-371	191	2	a	a	DET
eurjchem-371	191	3	solvent	solvent	NOUN
eurjchem-371	191	4	with	with	ADP
eurjchem-371	191	5	a	a	DET
eurjchem-371	191	6	high	high	ADJ
eurjchem-371	191	7	dielectric	dielectric	ADJ
eurjchem-371	191	8	constant	constant	ADJ
eurjchem-371	191	9	will	will	AUX
eurjchem-371	191	10	promote	promote	VERB
eurjchem-371	191	11	ionisation	ionisation	NOUN
eurjchem-371	191	12	.	.	PUNCT
eurjchem-371	192	1	for	for	ADP
eurjchem-371	192	2	a	a	DET
eurjchem-371	192	3	given	give	VERB
eurjchem-371	192	4	acid	acid	NOUN
eurjchem-371	192	5	,	,	PUNCT
eurjchem-371	192	6	pka	pka	PROPN
eurjchem-371	192	7	values	value	NOUN
eurjchem-371	192	8	will	will	AUX
eurjchem-371	192	9	vary	vary	VERB
eurjchem-371	192	10	depending	depend	VERB
eurjchem-371	192	11	on	on	ADP
eurjchem-371	192	12	the	the	DET
eurjchem-371	192	13	solvent	solvent	NOUN
eurjchem-371	192	14	.	.	PUNCT
eurjchem-371	193	1	the	the	DET
eurjchem-371	193	2	degree	degree	NOUN
eurjchem-371	193	3	of	of	ADP
eurjchem-371	193	4	dissociation	dissociation	NOUN
eurjchem-371	193	5	of	of	ADP
eurjchem-371	193	6	an	an	DET
eurjchem-371	193	7	acid	acid	NOUN
eurjchem-371	193	8	increases	increase	NOUN
eurjchem-371	193	9	with	with	ADP
eurjchem-371	193	10	increase	increase	NOUN
eurjchem-371	193	11	of	of	ADP
eurjchem-371	193	12	solvent	solvent	ADJ
eurjchem-371	193	13	basicity	basicity	NOUN
eurjchem-371	193	14	.	.	PUNCT
eurjchem-371	194	1	on	on	ADP
eurjchem-371	194	2	the	the	DET
eurjchem-371	194	3	other	other	ADJ
eurjchem-371	194	4	hand	hand	NOUN
eurjchem-371	194	5	,	,	PUNCT
eurjchem-371	194	6	dissociation	dissociation	NOUN
eurjchem-371	194	7	is	be	AUX
eurjchem-371	194	8	relatively	relatively	ADV
eurjchem-371	194	9	less	less	ADJ
eurjchem-371	194	10	for	for	ADP
eurjchem-371	194	11	solvents	solvent	NOUN
eurjchem-371	194	12	having	have	VERB
eurjchem-371	194	13	low	low	ADJ
eurjchem-371	194	14	dielectric	dielectric	ADJ
eurjchem-371	194	15	constant	constant	ADJ
eurjchem-371	194	16	.	.	PUNCT
eurjchem-371	195	1	co‐	co‐	NOUN
eurjchem-371	195	2	solvent	solvent	NOUN
eurjchem-371	195	3	properties	property	NOUN
eurjchem-371	195	4	used	use	VERB
eurjchem-371	195	5	in	in	ADP
eurjchem-371	195	6	the	the	DET
eurjchem-371	195	7	present	present	ADJ
eurjchem-371	195	8	studies	study	NOUN
eurjchem-371	195	9	are	be	AUX
eurjchem-371	195	10	provided	provide	VERB
eurjchem-371	195	11	in	in	ADP
eurjchem-371	195	12	table	table	NOUN
eurjchem-371	195	13	3	3	NUM
eurjchem-371	195	14	.	.	PUNCT
eurjchem-371	196	1	it	it	PRON
eurjchem-371	196	2	can	can	AUX
eurjchem-371	196	3	be	be	AUX
eurjchem-371	196	4	seen	see	VERB
eurjchem-371	196	5	from	from	ADP
eurjchem-371	196	6	the	the	DET
eurjchem-371	196	7	table	table	NOUN
eurjchem-371	196	8	that	that	SCONJ
eurjchem-371	196	9	methanol	methanol	NOUN
eurjchem-371	196	10	and	and	CCONJ
eurjchem-371	196	11	ethanol	ethanol	NOUN
eurjchem-371	196	12	is	be	AUX
eurjchem-371	196	13	more	more	ADV
eurjchem-371	196	14	basic	basic	ADJ
eurjchem-371	196	15	than	than	ADP
eurjchem-371	196	16	water	water	NOUN
eurjchem-371	196	17	,	,	PUNCT
eurjchem-371	196	18	but	but	CCONJ
eurjchem-371	196	19	its	its	PRON
eurjchem-371	196	20	dielectric	dielectric	ADJ
eurjchem-371	196	21	constant	constant	ADJ
eurjchem-371	196	22	is	be	AUX
eurjchem-371	196	23	less	less	ADJ
eurjchem-371	196	24	.	.	PUNCT
eurjchem-371	197	1	acetonitrile	acetonitrile	NOUN
eurjchem-371	197	2	is	be	AUX
eurjchem-371	197	3	less	less	ADV
eurjchem-371	197	4	basic	basic	ADJ
eurjchem-371	197	5	than	than	ADP
eurjchem-371	197	6	water	water	NOUN
eurjchem-371	197	7	,	,	PUNCT
eurjchem-371	197	8	methanol	methanol	NOUN
eurjchem-371	197	9	or	or	CCONJ
eurjchem-371	197	10	ethanol	ethanol	NOUN
eurjchem-371	197	11	,	,	PUNCT
eurjchem-371	197	12	but	but	CCONJ
eurjchem-371	197	13	its	its	PRON
eurjchem-371	197	14	dielectric	dielectric	ADJ
eurjchem-371	197	15	constant	constant	ADJ
eurjchem-371	197	16	is	be	AUX
eurjchem-371	197	17	more	more	ADJ
eurjchem-371	197	18	than	than	ADP
eurjchem-371	197	19	methanol	methanol	NOUN
eurjchem-371	197	20	or	or	CCONJ
eurjchem-371	197	21	ethanol	ethanol	NOUN
eurjchem-371	197	22	.	.	PUNCT
eurjchem-371	198	1	hence	hence	ADV
eurjchem-371	198	2	,	,	PUNCT
eurjchem-371	198	3	in	in	ADP
eurjchem-371	198	4	general	general	ADJ
eurjchem-371	198	5	,	,	PUNCT
eurjchem-371	198	6	acids	acid	NOUN
eurjchem-371	198	7	are	be	AUX
eurjchem-371	198	8	weaker	weak	ADJ
eurjchem-371	198	9	and	and	CCONJ
eurjchem-371	198	10	bases	basis	NOUN
eurjchem-371	198	11	are	be	AUX
eurjchem-371	198	12	stronger	strong	ADJ
eurjchem-371	198	13	in	in	ADP
eurjchem-371	198	14	this	this	DET
eurjchem-371	198	15	solvent	solvent	NOUN
eurjchem-371	198	16	.	.	PUNCT
eurjchem-371	199	1	narasimham	narasimham	PROPN
eurjchem-371	199	2	and	and	CCONJ
eurjchem-371	199	3	barhate	barhate	VERB
eurjchem-371	199	4	/	/	SYM
eurjchem-371	199	5	european	european	ADJ
eurjchem-371	199	6	journal	journal	PROPN
eurjchem-371	199	7	of	of	ADP
eurjchem-371	199	8	chemistry	chemistry	NOUN
eurjchem-371	199	9	2	2	NUM
eurjchem-371	199	10	(	(	PUNCT
eurjchem-371	199	11	1	1	NUM
eurjchem-371	199	12	)	)	PUNCT
eurjchem-371	199	13	(	(	PUNCT
eurjchem-371	199	14	2011	2011	NUM
eurjchem-371	199	15	)	)	PUNCT
eurjchem-371	199	16	36‐46	36‐46	NOUN
eurjchem-371	199	17	41	41	NUM
eurjchem-371	199	18	table	table	NOUN
eurjchem-371	199	19	3	3	NUM
eurjchem-371	199	20	.	.	PUNCT
eurjchem-371	199	21	solvent	solvent	ADJ
eurjchem-371	199	22	properties	property	NOUN
eurjchem-371	199	23	at	at	ADP
eurjchem-371	199	24	25	25	NUM
eurjchem-371	199	25	°	°	NOUN
eurjchem-371	199	26	c	c	NOUN
eurjchem-371	199	27	.	.	PUNCT
eurjchem-371	200	1	solvent	solvent	ADJ
eurjchem-371	200	2	dielectric	dielectric	ADJ
eurjchem-371	200	3	constant	constant	ADJ
eurjchem-371	200	4	donor	donor	NOUN
eurjchem-371	200	5	number	number	NOUN
eurjchem-371	200	6	(	(	PUNCT
eurjchem-371	200	7	kcal	kcal	NOUN
eurjchem-371	200	8	/	/	SYM
eurjchem-371	200	9	mol	mol	NOUN
eurjchem-371	200	10	)	)	PUNCT
eurjchem-371	200	11	water	water	NOUN
eurjchem-371	200	12	80	80	NUM
eurjchem-371	200	13	18	18	NUM
eurjchem-371	200	14	acetonitrile	acetonitrile	NOUN
eurjchem-371	200	15	37.5	37.5	NUM
eurjchem-371	200	16	14.1	14.1	NUM
eurjchem-371	200	17	methanol	methanol	NOUN
eurjchem-371	200	18	33	33	NUM
eurjchem-371	200	19	19	19	NUM
eurjchem-371	200	20	ethanol	ethanol	NOUN
eurjchem-371	200	21	24.3	24.3	NUM
eurjchem-371	200	22	31.5	31.5	NUM
eurjchem-371	200	23	1,4	1,4	NUM
eurjchem-371	200	24	‐	‐	ADJ
eurjchem-371	200	25	dioxane	dioxane	NOUN
eurjchem-371	200	26	2.3	2.3	NUM
eurjchem-371	200	27	14.8	14.8	NUM
eurjchem-371	200	28	figure	figure	NOUN
eurjchem-371	200	29	3	3	NUM
eurjchem-371	200	30	.	.	PUNCT
eurjchem-371	201	1	beta	beta	ADJ
eurjchem-371	201	2	blockers	blocker	NOUN
eurjchem-371	201	3	–	–	PUNCT
eurjchem-371	201	4	pska	pska	NOUN
eurjchem-371	201	5	trend	trend	NOUN
eurjchem-371	201	6	charts	chart	NOUN
eurjchem-371	201	7	by	by	ADP
eurjchem-371	201	8	potentiometry	potentiometry	PROPN
eurjchem-371	201	9	.	.	PUNCT
eurjchem-371	202	1	figure	figure	NOUN
eurjchem-371	202	2	4	4	NUM
eurjchem-371	202	3	.	.	PUNCT
eurjchem-371	202	4	anti‐diabetic	anti‐diabetic	ADJ
eurjchem-371	202	5	–	–	PUNCT
eurjchem-371	202	6	pska	pska	NOUN
eurjchem-371	202	7	trend	trend	NOUN
eurjchem-371	202	8	charts	chart	NOUN
eurjchem-371	202	9	by	by	ADP
eurjchem-371	202	10	potentiometry	potentiometry	NOUN
eurjchem-371	202	11	.	.	PUNCT
eurjchem-371	203	1	42	42	NUM
eurjchem-371	203	2	narasimham	narasimham	PROPN
eurjchem-371	203	3	and	and	CCONJ
eurjchem-371	203	4	barhate	barhate	VERB
eurjchem-371	203	5	/	/	SYM
eurjchem-371	203	6	european	european	ADJ
eurjchem-371	203	7	journal	journal	PROPN
eurjchem-371	203	8	of	of	ADP
eurjchem-371	203	9	chemistry	chemistry	NOUN
eurjchem-371	203	10	2	2	NUM
eurjchem-371	203	11	(	(	PUNCT
eurjchem-371	203	12	1	1	NUM
eurjchem-371	203	13	)	)	PUNCT
eurjchem-371	203	14	(	(	PUNCT
eurjchem-371	203	15	2011	2011	NUM
eurjchem-371	203	16	)	)	PUNCT
eurjchem-371	203	17	36‐46	36‐46	NUM
eurjchem-371	203	18	table	table	NOUN
eurjchem-371	203	19	4	4	NUM
eurjchem-371	203	20	.	.	PUNCT
eurjchem-371	203	21	effect	effect	NOUN
eurjchem-371	203	22	of	of	ADP
eurjchem-371	203	23	temperature	temperature	NOUN
eurjchem-371	203	24	on	on	ADP
eurjchem-371	203	25	the	the	DET
eurjchem-371	203	26	pska	pska	NOUN
eurjchem-371	203	27	values	value	NOUN
eurjchem-371	203	28	.	.	PUNCT
eurjchem-371	204	1	therapeutical	therapeutical	ADJ
eurjchem-371	204	2	class	class	NOUN
eurjchem-371	204	3	compound	compound	NOUN
eurjchem-371	204	4	co‐solvent	co‐solvent	ADJ
eurjchem-371	204	5	wt	wt	NOUN
eurjchem-371	204	6	%	%	NOUN
eurjchem-371	204	7	pska	pska	NOUN
eurjchem-371	204	8	i	i	PRON
eurjchem-371	204	9	(	(	PUNCT
eurjchem-371	204	10	m	m	NOUN
eurjchem-371	204	11	)	)	PUNCT
eurjchem-371	204	12	method	method	NOUN
eurjchem-371	204	13	25	25	NUM
eurjchem-371	204	14	°	°	SYM
eurjchem-371	204	15	c	c	PROPN
eurjchem-371	204	16	35	35	NUM
eurjchem-371	204	17	°	°	SYM
eurjchem-371	204	18	c	c	PROPN
eurjchem-371	204	19	45	45	NUM
eurjchem-371	204	20	°	°	NOUN
eurjchem-371	204	21	c	c	NOUN
eurjchem-371	204	22	beta	beta	ADJ
eurjchem-371	204	23	blockers	blocker	NOUN
eurjchem-371	204	24	aml	aml	PROPN
eurjchem-371	204	25	methanol	methanol	PROPN
eurjchem-371	204	26	40	40	NUM
eurjchem-371	204	27	8.91	8.91	NUM
eurjchem-371	204	28	8.74	8.74	NUM
eurjchem-371	204	29	8.57	8.57	NUM
eurjchem-371	204	30	0.15	0.15	NUM
eurjchem-371	204	31	potentiometric	potentiometric	ADJ
eurjchem-371	204	32	pro	pro	ADJ
eurjchem-371	204	33	9.04	9.04	NUM
eurjchem-371	204	34	8.88	8.88	NUM
eurjchem-371	204	35	8.73	8.73	NUM
eurjchem-371	205	1	potentiometric	potentiometric	ADJ
eurjchem-371	206	1	atn	atn	PROPN
eurjchem-371	206	2	9.13	9.13	NUM
eurjchem-371	206	3	8.84	8.84	NUM
eurjchem-371	206	4	8.57	8.57	NUM
eurjchem-371	206	5	potentiometric	potentiometric	PROPN
eurjchem-371	206	6	mt	mt	PROPN
eurjchem-371	206	7	9.10	9.10	NUM
eurjchem-371	206	8	8.88	8.88	NUM
eurjchem-371	206	9	8.68	8.68	NUM
eurjchem-371	206	10	potentiometric	potentiometric	NOUN
eurjchem-371	206	11	ab	ab	PROPN
eurjchem-371	206	12	8.99	8.99	NUM
eurjchem-371	206	13	8.73	8.73	NUM
eurjchem-371	206	14	8.50	8.50	NUM
eurjchem-371	206	15	potentiometric	potentiometric	ADJ
eurjchem-371	206	16	anti‐diabetics	anti‐diabetic	NOUN
eurjchem-371	206	17	glc	glc	PROPN
eurjchem-371	206	18	5.94	5.94	NUM
eurjchem-371	206	19	5.86	5.86	NUM
eurjchem-371	206	20	5.81	5.81	NUM
eurjchem-371	206	21	potentiometric	potentiometric	NOUN
eurjchem-371	206	22	pio	pio	PROPN
eurjchem-371	206	23	5.01	5.01	NUM
eurjchem-371	206	24	4.86	4.86	NUM
eurjchem-371	206	25	4.67	4.67	NUM
eurjchem-371	206	26	potentiometric	potentiometric	NOUN
eurjchem-371	206	27	glz	glz	ADV
eurjchem-371	206	28	5.86	5.86	NUM
eurjchem-371	206	29	5.81	5.81	NUM
eurjchem-371	206	30	5.76	5.76	NUM
eurjchem-371	206	31	potentiometric	potentiometric	ADJ
eurjchem-371	206	32	table	table	NOUN
eurjchem-371	206	33	5	5	NUM
eurjchem-371	206	34	.	.	PUNCT
eurjchem-371	206	35	effect	effect	NOUN
eurjchem-371	206	36	of	of	ADP
eurjchem-371	206	37	ionic	ionic	ADJ
eurjchem-371	206	38	strength	strength	NOUN
eurjchem-371	206	39	on	on	ADP
eurjchem-371	206	40	the	the	DET
eurjchem-371	206	41	pska	pska	NOUN
eurjchem-371	206	42	values	value	NOUN
eurjchem-371	206	43	.	.	PUNCT
eurjchem-371	207	1	therapeutical	therapeutical	ADJ
eurjchem-371	207	2	class	class	NOUN
eurjchem-371	207	3	compound	compound	NOUN
eurjchem-371	207	4	co‐solvent	co‐solvent	ADJ
eurjchem-371	207	5	wt	wt	NOUN
eurjchem-371	207	6	%	%	NOUN
eurjchem-371	207	7	pska	pska	NOUN
eurjchem-371	207	8	temp	temp	NOUN
eurjchem-371	207	9	°	°	PROPN
eurjchem-371	207	10	c	c	NOUN
eurjchem-371	207	11	method	method	NOUN
eurjchem-371	207	12	0.15	0.15	NUM
eurjchem-371	207	13	m	m	NOUN
eurjchem-371	207	14	0.3	0.3	NUM
eurjchem-371	207	15	m	m	NUM
eurjchem-371	207	16	0.5	0.5	NUM
eurjchem-371	207	17	m	m	NOUN
eurjchem-371	207	18	beta	beta	NOUN
eurjchem-371	207	19	blockers	blocker	NOUN
eurjchem-371	207	20	aml	aml	PROPN
eurjchem-371	207	21	methanol	methanol	PROPN
eurjchem-371	207	22	40	40	NUM
eurjchem-371	207	23	8.91	8.91	NUM
eurjchem-371	207	24	8.96	8.96	NUM
eurjchem-371	207	25	9.01	9.01	NUM
eurjchem-371	207	26	25	25	NUM
eurjchem-371	207	27	potentiometric	potentiometric	ADJ
eurjchem-371	207	28	pro	pro	X
eurjchem-371	207	29	9.04	9.04	NUM
eurjchem-371	207	30	9.08	9.08	NUM
eurjchem-371	207	31	9.15	9.15	NUM
eurjchem-371	207	32	potentiometric	potentiometric	NOUN
eurjchem-371	207	33	atn	atn	PROPN
eurjchem-371	207	34	9.13	9.13	NUM
eurjchem-371	207	35	9.18	9.18	NUM
eurjchem-371	207	36	9.25	9.25	NUM
eurjchem-371	207	37	potentiometric	potentiometric	ADJ
eurjchem-371	207	38	mt	mt	PROPN
eurjchem-371	207	39	9.10	9.10	NUM
eurjchem-371	207	40	9.12	9.12	NUM
eurjchem-371	207	41	9.15	9.15	NUM
eurjchem-371	207	42	potentiometric	potentiometric	NOUN
eurjchem-371	207	43	ab	ab	PROPN
eurjchem-371	207	44	8.99	8.99	NUM
eurjchem-371	207	45	9.04	9.04	NUM
eurjchem-371	207	46	9.09	9.09	NUM
eurjchem-371	207	47	potentiometric	potentiometric	ADJ
eurjchem-371	207	48	anti‐diabetics	anti‐diabetics	PROPN
eurjchem-371	207	49	glc	glc	PROPN
eurjchem-371	207	50	5.94	5.94	NUM
eurjchem-371	207	51	5.96	5.96	NUM
eurjchem-371	207	52	5.98	5.98	NUM
eurjchem-371	207	53	potentiometric	potentiometric	ADJ
eurjchem-371	207	54	pio	pio	PROPN
eurjchem-371	207	55	5.01	5.01	NUM
eurjchem-371	207	56	5.06	5.06	NUM
eurjchem-371	207	57	5.14	5.14	NUM
eurjchem-371	207	58	potentiometric	potentiometric	NOUN
eurjchem-371	207	59	glz	glz	ADV
eurjchem-371	207	60	5.86	5.86	NUM
eurjchem-371	207	61	5.90	5.90	NUM
eurjchem-371	207	62	5.94	5.94	NUM
eurjchem-371	207	63	potentiometric	potentiometric	ADJ
eurjchem-371	207	64	figure	figure	NOUN
eurjchem-371	207	65	5	5	NUM
eurjchem-371	207	66	.	.	PUNCT
eurjchem-371	207	67	effect	effect	NOUN
eurjchem-371	207	68	of	of	ADP
eurjchem-371	207	69	temperature	temperature	NOUN
eurjchem-371	207	70	on	on	ADP
eurjchem-371	207	71	ionization	ionization	NOUN
eurjchem-371	207	72	constant	constant	ADJ
eurjchem-371	207	73	.	.	PUNCT
eurjchem-371	208	1	figure	figure	NOUN
eurjchem-371	208	2	6	6	NUM
eurjchem-371	208	3	.	.	PUNCT
eurjchem-371	209	1	effect	effect	NOUN
eurjchem-371	209	2	of	of	ADP
eurjchem-371	209	3	ionic	ionic	ADJ
eurjchem-371	209	4	strength	strength	NOUN
eurjchem-371	209	5	on	on	ADP
eurjchem-371	209	6	ionization	ionization	NOUN
eurjchem-371	209	7	constant	constant	ADJ
eurjchem-371	209	8	.	.	PUNCT
eurjchem-371	210	1	figure	figure	NOUN
eurjchem-371	210	2	5	5	NUM
eurjchem-371	210	3	and	and	CCONJ
eurjchem-371	210	4	6	6	NUM
eurjchem-371	210	5	represent	represent	VERB
eurjchem-371	210	6	the	the	DET
eurjchem-371	210	7	pska	pska	NOUN
eurjchem-371	210	8	value	value	NOUN
eurjchem-371	210	9	trend	trend	NOUN
eurjchem-371	210	10	charts	chart	NOUN
eurjchem-371	210	11	of	of	ADP
eurjchem-371	210	12	selected	select	VERB
eurjchem-371	210	13	compounds	compound	NOUN
eurjchem-371	210	14	due	due	ADP
eurjchem-371	210	15	to	to	ADP
eurjchem-371	210	16	temperature	temperature	NOUN
eurjchem-371	210	17	and	and	CCONJ
eurjchem-371	210	18	ionic	ionic	ADJ
eurjchem-371	210	19	strength	strength	NOUN
eurjchem-371	210	20	effect	effect	NOUN
eurjchem-371	210	21	,	,	PUNCT
eurjchem-371	210	22	respectively	respectively	ADV
eurjchem-371	210	23	.	.	PUNCT
eurjchem-371	211	1	it	it	PRON
eurjchem-371	211	2	is	be	AUX
eurjchem-371	211	3	evident	evident	ADJ
eurjchem-371	211	4	from	from	ADP
eurjchem-371	211	5	these	these	DET
eurjchem-371	211	6	trend	trend	NOUN
eurjchem-371	211	7	charts	chart	NOUN
eurjchem-371	211	8	that	that	SCONJ
eurjchem-371	211	9	the	the	DET
eurjchem-371	211	10	dissociation	dissociation	NOUN
eurjchem-371	211	11	constants	constant	NOUN
eurjchem-371	211	12	of	of	ADP
eurjchem-371	211	13	all	all	DET
eurjchem-371	211	14	the	the	DET
eurjchem-371	211	15	drugs	drug	NOUN
eurjchem-371	211	16	decreased	decrease	VERB
eurjchem-371	211	17	with	with	ADP
eurjchem-371	211	18	increasing	increase	VERB
eurjchem-371	211	19	temperature	temperature	NOUN
eurjchem-371	211	20	,	,	PUNCT
eurjchem-371	211	21	while	while	SCONJ
eurjchem-371	211	22	same	same	ADJ
eurjchem-371	211	23	compounds	compound	NOUN
eurjchem-371	211	24	showed	show	VERB
eurjchem-371	211	25	increasing	increase	VERB
eurjchem-371	211	26	trend	trend	NOUN
eurjchem-371	211	27	with	with	ADP
eurjchem-371	211	28	increasing	increase	VERB
eurjchem-371	211	29	ionic	ionic	ADJ
eurjchem-371	211	30	strength	strength	NOUN
eurjchem-371	211	31	.	.	PUNCT
eurjchem-371	212	1	this	this	PRON
eurjchem-371	212	2	is	be	AUX
eurjchem-371	212	3	in	in	ADP
eurjchem-371	212	4	good	good	ADJ
eurjchem-371	212	5	agreement	agreement	NOUN
eurjchem-371	212	6	with	with	ADP
eurjchem-371	212	7	the	the	DET
eurjchem-371	212	8	literature	literature	NOUN
eurjchem-371	212	9	findings	finding	NOUN
eurjchem-371	212	10	.	.	PUNCT
eurjchem-371	213	1	the	the	DET
eurjchem-371	213	2	results	result	NOUN
eurjchem-371	213	3	are	be	AUX
eurjchem-371	213	4	presented	present	VERB
eurjchem-371	213	5	in	in	ADP
eurjchem-371	213	6	table	table	NOUN
eurjchem-371	213	7	4	4	NUM
eurjchem-371	213	8	and	and	CCONJ
eurjchem-371	213	9	5	5	NUM
eurjchem-371	213	10	.	.	X
eurjchem-371	213	11	analysis	analysis	NOUN
eurjchem-371	213	12	of	of	ADP
eurjchem-371	213	13	the	the	DET
eurjchem-371	213	14	slope	slope	NOUN
eurjchem-371	213	15	of	of	ADP
eurjchem-371	213	16	ys	ys	PROPN
eurjchem-371	213	17	equations	equation	NOUN
eurjchem-371	213	18	allows	allow	VERB
eurjchem-371	213	19	us	we	PRON
eurjchem-371	213	20	to	to	PART
eurjchem-371	213	21	have	have	VERB
eurjchem-371	213	22	a	a	DET
eurjchem-371	213	23	better	well	ADJ
eurjchem-371	213	24	insight	insight	NOUN
eurjchem-371	213	25	into	into	ADP
eurjchem-371	213	26	the	the	DET
eurjchem-371	213	27	solvation	solvation	NOUN
eurjchem-371	213	28	effect	effect	NOUN
eurjchem-371	213	29	of	of	ADP
eurjchem-371	213	30	the	the	DET
eurjchem-371	213	31	different	different	ADJ
eurjchem-371	213	32	co	co	ADJ
eurjchem-371	213	33	solvent	solvent	ADJ
eurjchem-371	213	34	mixtures	mixture	NOUN
eurjchem-371	213	35	upon	upon	SCONJ
eurjchem-371	213	36	the	the	DET
eurjchem-371	213	37	ionization	ionization	NOUN
eurjchem-371	213	38	of	of	ADP
eurjchem-371	213	39	different	different	ADJ
eurjchem-371	213	40	functional	functional	ADJ
eurjchem-371	213	41	groups	group	NOUN
eurjchem-371	213	42	.	.	PUNCT
eurjchem-371	214	1	this	this	PRON
eurjchem-371	214	2	can	can	AUX
eurjchem-371	214	3	be	be	AUX
eurjchem-371	214	4	better	well	ADV
eurjchem-371	214	5	explained	explain	VERB
eurjchem-371	214	6	in	in	ADP
eurjchem-371	214	7	case	case	NOUN
eurjchem-371	214	8	of	of	ADP
eurjchem-371	214	9	aml	aml	PROPN
eurjchem-371	214	10	,	,	PUNCT
eurjchem-371	214	11	where	where	SCONJ
eurjchem-371	214	12	it	it	PRON
eurjchem-371	214	13	being	be	AUX
eurjchem-371	214	14	a	a	DET
eurjchem-371	214	15	base	base	NOUN
eurjchem-371	214	16	,	,	PUNCT
eurjchem-371	214	17	positive	positive	ADJ
eurjchem-371	214	18	slope	slope	NOUN
eurjchem-371	214	19	was	be	AUX
eurjchem-371	214	20	observed	observe	VERB
eurjchem-371	214	21	for	for	ADP
eurjchem-371	214	22	both	both	CCONJ
eurjchem-371	214	23	acetonitrile	acetonitrile	NOUN
eurjchem-371	214	24	and	and	CCONJ
eurjchem-371	214	25	dioxane	dioxane	NOUN
eurjchem-371	214	26	solvent	solvent	NOUN
eurjchem-371	214	27	.	.	PUNCT
eurjchem-371	215	1	this	this	PRON
eurjchem-371	215	2	has	have	AUX
eurjchem-371	215	3	been	be	AUX
eurjchem-371	215	4	validated	validate	VERB
eurjchem-371	215	5	by	by	ADP
eurjchem-371	215	6	both	both	DET
eurjchem-371	215	7	potentiometry	potentiometry	NOUN
eurjchem-371	215	8	and	and	CCONJ
eurjchem-371	215	9	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	215	10	methods	method	NOUN
eurjchem-371	215	11	.	.	PUNCT
eurjchem-371	216	1	comparatively	comparatively	ADV
eurjchem-371	216	2	,	,	PUNCT
eurjchem-371	216	3	significant	significant	ADJ
eurjchem-371	216	4	lower	low	ADJ
eurjchem-371	216	5	slope	slope	NOUN
eurjchem-371	216	6	values	value	NOUN
eurjchem-371	216	7	in	in	ADP
eurjchem-371	216	8	1,4‐dioxane	1,4‐dioxane	NUM
eurjchem-371	216	9	in	in	ADP
eurjchem-371	216	10	almost	almost	ADV
eurjchem-371	216	11	all	all	DET
eurjchem-371	216	12	the	the	DET
eurjchem-371	216	13	selected	select	VERB
eurjchem-371	216	14	compounds	compound	NOUN
eurjchem-371	216	15	,	,	PUNCT
eurjchem-371	216	16	with	with	ADP
eurjchem-371	216	17	the	the	DET
eurjchem-371	216	18	exception	exception	NOUN
eurjchem-371	216	19	of	of	ADP
eurjchem-371	216	20	glz	glz	NOUN
eurjchem-371	216	21	,	,	PUNCT
eurjchem-371	216	22	indicate	indicate	VERB
eurjchem-371	216	23	higher	high	ADJ
eurjchem-371	216	24	ionic	ionic	ADJ
eurjchem-371	216	25	diameters	diameter	NOUN
eurjchem-371	216	26	of	of	ADP
eurjchem-371	216	27	the	the	DET
eurjchem-371	216	28	solvated	solvate	VERB
eurjchem-371	216	29	molecules	molecule	NOUN
eurjchem-371	216	30	in	in	ADP
eurjchem-371	216	31	the	the	DET
eurjchem-371	216	32	four‐component	four‐component	ADJ
eurjchem-371	216	33	solvent	solvent	NOUN
eurjchem-371	216	34	system	system	NOUN
eurjchem-371	216	35	.	.	PUNCT
eurjchem-371	217	1	in	in	ADP
eurjchem-371	217	2	solvents	solvent	NOUN
eurjchem-371	217	3	having	have	VERB
eurjchem-371	217	4	low	low	ADJ
eurjchem-371	217	5	dielectric	dielectric	ADJ
eurjchem-371	217	6	constant	constant	ADJ
eurjchem-371	217	7	,	,	PUNCT
eurjchem-371	217	8	ions	ion	NOUN
eurjchem-371	217	9	tend	tend	VERB
eurjchem-371	217	10	to	to	PART
eurjchem-371	217	11	associate	associate	VERB
eurjchem-371	217	12	,	,	PUNCT
eurjchem-371	217	13	which	which	PRON
eurjchem-371	217	14	complicates	complicate	VERB
eurjchem-371	217	15	the	the	DET
eurjchem-371	217	16	interpretation	interpretation	NOUN
eurjchem-371	217	17	of	of	ADP
eurjchem-371	217	18	pkas	pkas	NOUN
eurjchem-371	217	19	.	.	PUNCT
eurjchem-371	218	1	in	in	ADP
eurjchem-371	218	2	particular	particular	ADJ
eurjchem-371	218	3	,	,	PUNCT
eurjchem-371	218	4	in	in	ADP
eurjchem-371	218	5	aprotic	aprotic	ADJ
eurjchem-371	218	6	solvents	solvent	NOUN
eurjchem-371	218	7	the	the	DET
eurjchem-371	218	8	process	process	NOUN
eurjchem-371	218	9	of	of	ADP
eurjchem-371	218	10	homo‐	homo‐	PROPN
eurjchem-371	218	11	conjugation	conjugation	PROPN
eurjchem-371	218	12	occurs	occur	VERB
eurjchem-371	218	13	when	when	SCONJ
eurjchem-371	218	14	the	the	DET
eurjchem-371	218	15	conjugate	conjugate	ADJ
eurjchem-371	218	16	base	base	NOUN
eurjchem-371	218	17	forms	form	VERB
eurjchem-371	218	18	a	a	DET
eurjchem-371	218	19	hydrogen	hydrogen	NOUN
eurjchem-371	218	20	bond	bond	NOUN
eurjchem-371	218	21	with	with	ADP
eurjchem-371	218	22	the	the	DET
eurjchem-371	218	23	parent	parent	NOUN
eurjchem-371	218	24	acid	acid	NOUN
eurjchem-371	219	1	[	[	X
eurjchem-371	219	2	34].the	34].the	DET
eurjchem-371	219	3	slope	slope	NOUN
eurjchem-371	219	4	values	value	NOUN
eurjchem-371	219	5	of	of	ADP
eurjchem-371	219	6	all	all	DET
eurjchem-371	219	7	the	the	DET
eurjchem-371	219	8	compounds	compound	NOUN
eurjchem-371	219	9	in	in	ADP
eurjchem-371	219	10	different	different	ADJ
eurjchem-371	219	11	co	co	NOUN
eurjchem-371	219	12	solvents	solvent	NOUN
eurjchem-371	219	13	chosen	choose	VERB
eurjchem-371	219	14	in	in	ADP
eurjchem-371	219	15	the	the	DET
eurjchem-371	219	16	present	present	ADJ
eurjchem-371	219	17	study	study	NOUN
eurjchem-371	219	18	having	have	VERB
eurjchem-371	219	19	the	the	DET
eurjchem-371	219	20	same	same	ADJ
eurjchem-371	219	21	ionisation	ionisation	NOUN
eurjchem-371	219	22	groups	group	NOUN
eurjchem-371	219	23	are	be	AUX
eurjchem-371	219	24	presented	present	VERB
eurjchem-371	219	25	in	in	ADP
eurjchem-371	219	26	table	table	NOUN
eurjchem-371	219	27	6	6	NUM
eurjchem-371	219	28	.	.	PUNCT
eurjchem-371	220	1	narasimham	narasimham	PROPN
eurjchem-371	220	2	and	and	CCONJ
eurjchem-371	220	3	barhate	barhate	VERB
eurjchem-371	220	4	/	/	SYM
eurjchem-371	220	5	european	european	ADJ
eurjchem-371	220	6	journal	journal	PROPN
eurjchem-371	220	7	of	of	ADP
eurjchem-371	220	8	chemistry	chemistry	NOUN
eurjchem-371	220	9	2	2	NUM
eurjchem-371	220	10	(	(	PUNCT
eurjchem-371	220	11	1	1	NUM
eurjchem-371	220	12	)	)	PUNCT
eurjchem-371	220	13	(	(	PUNCT
eurjchem-371	220	14	2011	2011	NUM
eurjchem-371	220	15	)	)	PUNCT
eurjchem-371	220	16	36‐46	36‐46	NOUN
eurjchem-371	220	17	43	43	NUM
eurjchem-371	220	18	table	table	NOUN
eurjchem-371	220	19	6	6	NUM
eurjchem-371	220	20	.	.	PUNCT
eurjchem-371	220	21	comparison	comparison	NOUN
eurjchem-371	220	22	of	of	ADP
eurjchem-371	220	23	slope	slope	NOUN
eurjchem-371	220	24	for	for	ADP
eurjchem-371	220	25	the	the	DET
eurjchem-371	220	26	compounds	compound	NOUN
eurjchem-371	220	27	having	have	VERB
eurjchem-371	220	28	isopropyl	isopropyl	NOUN
eurjchem-371	220	29	amine	amine	ADJ
eurjchem-371	220	30	groups	group	NOUN
eurjchem-371	220	31	.	.	PUNCT
eurjchem-371	221	1	compound	compound	NOUN
eurjchem-371	221	2	ionisation	ionisation	NOUN
eurjchem-371	221	3	group	group	NOUN
eurjchem-371	221	4	slope	slope	NOUN
eurjchem-371	221	5	methanol	methanol	NOUN
eurjchem-371	221	6	ethanol	ethanol	NOUN
eurjchem-371	221	7	acetonitrile	acetonitrile	NOUN
eurjchem-371	221	8	1,4	1,4	NUM
eurjchem-371	221	9	‐	‐	NOUN
eurjchem-371	221	10	dioxane	dioxane	NOUN
eurjchem-371	221	11	ph	ph	NOUN
eurjchem-371	221	12	metry	metry	NOUN
eurjchem-371	221	13	uv	uv	NOUN
eurjchem-371	221	14	/	/	SYM
eurjchem-371	221	15	ph	ph	ADJ
eurjchem-371	221	16	ph	ph	NOUN
eurjchem-371	221	17	metry	metry	NOUN
eurjchem-371	221	18	uv	uv	NOUN
eurjchem-371	221	19	/	/	SYM
eurjchem-371	221	20	ph	ph	ADJ
eurjchem-371	221	21	ph	ph	NOUN
eurjchem-371	221	22	metry	metry	NOUN
eurjchem-371	221	23	uv	uv	NOUN
eurjchem-371	221	24	/	/	SYM
eurjchem-371	221	25	ph	ph	ADJ
eurjchem-371	221	26	ph	ph	NOUN
eurjchem-371	221	27	metry	metry	NOUN
eurjchem-371	221	28	uv	uv	NOUN
eurjchem-371	221	29	/	/	SYM
eurjchem-371	221	30	ph	ph	ADJ
eurjchem-371	221	31	aml	aml	PROPN
eurjchem-371	221	32	guanidine	guanidine	NOUN
eurjchem-371	221	33	‐20.7	‐20.7	PROPN
eurjchem-371	221	34	‐61.1	‐61.1	NUM
eurjchem-371	221	35	‐25.8	‐25.8	ADP
eurjchem-371	221	36	‐21.1	‐21.1	NUM
eurjchem-371	221	37	41.9	41.9	NUM
eurjchem-371	221	38	69.2	69.2	NUM
eurjchem-371	221	39	10.2	10.2	NUM
eurjchem-371	221	40	19.3	19.3	NUM
eurjchem-371	221	41	pro	pro	ADJ
eurjchem-371	221	42	iso	iso	NOUN
eurjchem-371	221	43	propyl	propyl	ADJ
eurjchem-371	221	44	amine	amine	ADJ
eurjchem-371	221	45	‐146.3	‐146.3	NOUN
eurjchem-371	221	46	‐188.1	‐188.1	PROPN
eurjchem-371	221	47	‐179.9	‐179.9	VERB
eurjchem-371	221	48	‐115.4	‐115.4	NOUN
eurjchem-371	221	49	‐223.7	‐223.7	NOUN
eurjchem-371	221	50	‐107.1	‐107.1	NOUN
eurjchem-371	221	51	‐41.1	‐41.1	NOUN
eurjchem-371	221	52	‐12.7	‐12.7	NUM
eurjchem-371	221	53	atn	atn	PROPN
eurjchem-371	221	54	‐138.6	‐138.6	PROPN
eurjchem-371	221	55	‐184.8	‐184.8	VERB
eurjchem-371	221	56	‐207.1	‐207.1	NOUN
eurjchem-371	221	57	‐114.4	‐114.4	NOUN
eurjchem-371	221	58	‐222.5	‐222.5	NOUN
eurjchem-371	221	59	‐57.7	‐57.7	NUM
eurjchem-371	221	60	‐30.3	‐30.3	PROPN
eurjchem-371	221	61	‐13.3	‐13.3	PROPN
eurjchem-371	221	62	mt	mt	PROPN
eurjchem-371	221	63	‐163.2	‐163.2	PROPN
eurjchem-371	221	64	na	na	ADP
eurjchem-371	221	65	‐183.7	‐183.7	NOUN
eurjchem-371	221	66	na	na	ADP
eurjchem-371	221	67	‐216.6	‐216.6	NOUN
eurjchem-371	221	68	na	na	PART
eurjchem-371	221	69	‐7.7	‐7.7	NOUN
eurjchem-371	221	70	na	na	ADP
eurjchem-371	221	71	ab	ab	PROPN
eurjchem-371	221	72	primary	primary	ADJ
eurjchem-371	221	73	amine	amine	PROPN
eurjchem-371	221	74	‐108.7	‐108.7	NOUN
eurjchem-371	221	75	na	na	ADP
eurjchem-371	221	76	‐199.4	‐199.4	NOUN
eurjchem-371	221	77	na	na	ADP
eurjchem-371	221	78	‐387.7	‐387.7	PROPN
eurjchem-371	221	79	na	na	NOUN
eurjchem-371	221	80	‐34.6	‐34.6	NOUN
eurjchem-371	221	81	na	na	ADP
eurjchem-371	221	82	pio	pio	PROPN
eurjchem-371	221	83	pyridine	pyridine	NOUN
eurjchem-371	221	84	‐174.7	‐174.7	PROPN
eurjchem-371	221	85	na	na	PART
eurjchem-371	221	86	‐192.1	‐192.1	VERB
eurjchem-371	221	87	na	na	ADP
eurjchem-371	221	88	‐131.0	‐131.0	PROPN
eurjchem-371	221	89	na	na	ADP
eurjchem-371	221	90	‐19.4	‐19.4	PROPN
eurjchem-371	221	91	na	na	PART
eurjchem-371	221	92	glc	glc	PROPN
eurjchem-371	221	93	sulfonyl	sulfonyl	PROPN
eurjchem-371	221	94	urea	urea	PROPN
eurjchem-371	221	95	25.8	25.8	NUM
eurjchem-371	221	96	32.8	32.8	NUM
eurjchem-371	221	97	11.8	11.8	NUM
eurjchem-371	221	98	28.3	28.3	NUM
eurjchem-371	221	99	177.8	177.8	NUM
eurjchem-371	221	100	111.3	111.3	NUM
eurjchem-371	221	101	50.6	50.6	NUM
eurjchem-371	221	102	69.9	69.9	NUM
eurjchem-371	221	103	glz	glz	NOUN
eurjchem-371	221	104	110.2	110.2	NUM
eurjchem-371	221	105	na	na	PART
eurjchem-371	221	106	36.3	36.3	NUM
eurjchem-371	221	107	na	na	PART
eurjchem-371	221	108	110	110	NUM
eurjchem-371	221	109	na	na	PART
eurjchem-371	221	110	94.3	94.3	NUM
eurjchem-371	221	111	na	na	ADP
eurjchem-371	221	112	table	table	NOUN
eurjchem-371	221	113	7	7	NUM
eurjchem-371	221	114	.	.	PUNCT
eurjchem-371	222	1	the	the	DET
eurjchem-371	222	2	percentage	percentage	NOUN
eurjchem-371	222	3	of	of	ADP
eurjchem-371	222	4	the	the	DET
eurjchem-371	222	5	species	specie	NOUN
eurjchem-371	222	6	in	in	ADP
eurjchem-371	222	7	stomach	stomach	NOUN
eurjchem-371	222	8	,	,	PUNCT
eurjchem-371	222	9	gastrointestinal	gastrointestinal	ADJ
eurjchem-371	222	10	tract	tract	NOUN
eurjchem-371	222	11	and	and	CCONJ
eurjchem-371	222	12	plasma	plasma	NOUN
eurjchem-371	222	13	.	.	PUNCT
eurjchem-371	223	1	compound	compound	NOUN
eurjchem-371	223	2	percentage	percentage	NOUN
eurjchem-371	223	3	concentration	concentration	NOUN
eurjchem-371	223	4	stomach	stomach	NOUN
eurjchem-371	223	5	ph	ph	VERB
eurjchem-371	223	6	1.5	1.5	NUM
eurjchem-371	223	7	small	small	ADJ
eurjchem-371	223	8	intestine	intestine	NOUN
eurjchem-371	223	9	(	(	PUNCT
eurjchem-371	223	10	jejunum	jejunum	ADJ
eurjchem-371	223	11	)	)	PUNCT
eurjchem-371	223	12	ph	ph	PROPN
eurjchem-371	223	13	6.5	6.5	NUM
eurjchem-371	223	14	plasma	plasma	NOUN
eurjchem-371	223	15	ph	ph	NOUN
eurjchem-371	223	16	7.4	7.4	NUM
eurjchem-371	223	17	ba	ba	NOUN
eurjchem-371	223	18	bh+a	bh+a	PROPN
eurjchem-371	223	19	ba	ba	PROPN
eurjchem-371	224	1	bh+a	bh+a	PROPN
eurjchem-371	224	2	ba	ba	PROPN
eurjchem-371	224	3	bh+a	bh+a	PROPN
eurjchem-371	224	4	aml	aml	PROPN
eurjchem-371	224	5	0	0	NUM
eurjchem-371	224	6	100	100	NUM
eurjchem-371	224	7	1.21	1.21	NUM
eurjchem-371	224	8	98.79	98.79	NUM
eurjchem-371	224	9	8.89	8.89	NUM
eurjchem-371	224	10	91.11	91.11	NUM
eurjchem-371	224	11	pro	pro	X
eurjchem-371	224	12	0	0	NUM
eurjchem-371	224	13	100	100	NUM
eurjchem-371	224	14	38.01	38.01	NUM
eurjchem-371	224	15	61.99	61.99	NUM
eurjchem-371	224	16	17.03	17.03	NUM
eurjchem-371	224	17	82.97	82.97	NUM
eurjchem-371	224	18	atn	atn	NOUN
eurjchem-371	224	19	0	0	NUM
eurjchem-371	224	20	100	100	NUM
eurjchem-371	224	21	0.29	0.29	NUM
eurjchem-371	224	22	99.71	99.71	NUM
eurjchem-371	224	23	2.26	2.26	NUM
eurjchem-371	224	24	97.74	97.74	NUM
eurjchem-371	224	25	mt	mt	PROPN
eurjchem-371	224	26	0	0	NUM
eurjchem-371	224	27	100	100	NUM
eurjchem-371	224	28	8.20	8.20	NUM
eurjchem-371	224	29	91.80	91.80	NUM
eurjchem-371	224	30	58.49	58.49	NUM
eurjchem-371	224	31	41.51	41.51	NUM
eurjchem-371	224	32	ab	ab	NOUN
eurjchem-371	224	33	0	0	NUM
eurjchem-371	224	34	100	100	NUM
eurjchem-371	224	35	15.16	15.16	NUM
eurjchem-371	224	36	84.84	84.84	NUM
eurjchem-371	224	37	58.68	58.68	NUM
eurjchem-371	224	38	41.32	41.32	NUM
eurjchem-371	224	39	compound	compound	NOUN
eurjchem-371	224	40	percentage	percentage	NOUN
eurjchem-371	224	41	concentration	concentration	NOUN
eurjchem-371	224	42	stomach	stomach	NOUN
eurjchem-371	224	43	ph	ph	VERB
eurjchem-371	224	44	1.5	1.5	NUM
eurjchem-371	224	45	small	small	ADJ
eurjchem-371	224	46	intestine	intestine	NOUN
eurjchem-371	224	47	(	(	PUNCT
eurjchem-371	224	48	jejunum	jejunum	ADJ
eurjchem-371	224	49	)	)	PUNCT
eurjchem-371	224	50	ph	ph	PROPN
eurjchem-371	224	51	6.5	6.5	NUM
eurjchem-371	224	52	plasma	plasma	NOUN
eurjchem-371	224	53	ph	ph	NOUN
eurjchem-371	224	54	7.4	7.4	NUM
eurjchem-371	224	55	a‐b	a‐b	ADP
eurjchem-371	224	56	ahb	ahb	NOUN
eurjchem-371	224	57	a‐b	a‐b	ADP
eurjchem-371	224	58	ahb	ahb	NOUN
eurjchem-371	224	59	a‐	a‐	NOUN
eurjchem-371	224	60	b	b	NUM
eurjchem-371	225	1	ahb	ahb	PROPN
eurjchem-371	225	2	glc	glc	PROPN
eurjchem-371	225	3	0	0	NUM
eurjchem-371	225	4	100	100	NUM
eurjchem-371	225	5	8.20	8.20	NUM
eurjchem-371	225	6	91.80	91.80	NUM
eurjchem-371	225	7	41.52	41.52	NUM
eurjchem-371	225	8	58.48	58.48	NUM
eurjchem-371	225	9	glb	glb	NOUN
eurjchem-371	225	10	0	0	NUM
eurjchem-371	225	11	100	100	NUM
eurjchem-371	225	12	1.41	1.41	NUM
eurjchem-371	225	13	98.59	98.59	NUM
eurjchem-371	225	14	10.21	10.21	NUM
eurjchem-371	225	15	89.79	89.79	NUM
eurjchem-371	225	16	glz	glz	NOUN
eurjchem-371	225	17	0	0	NUM
eurjchem-371	225	18	100	100	NUM
eurjchem-371	225	19	6.59	6.59	NUM
eurjchem-371	225	20	93.41	93.41	NUM
eurjchem-371	225	21	35.93	35.93	NUM
eurjchem-371	225	22	64.07	64.07	NUM
eurjchem-371	225	23	amonovalent	amonovalent	NOUN
eurjchem-371	225	24	bases	basis	NOUN
eurjchem-371	225	25	.	.	PUNCT
eurjchem-371	226	1	bacid	bacid	NOUN
eurjchem-371	226	2	.	.	PUNCT
eurjchem-371	227	1	further	far	ADV
eurjchem-371	227	2	,	,	PUNCT
eurjchem-371	227	3	we	we	PRON
eurjchem-371	227	4	used	use	VERB
eurjchem-371	227	5	the	the	DET
eurjchem-371	227	6	pka	pka	PROPN
eurjchem-371	227	7	values	value	NOUN
eurjchem-371	227	8	to	to	PART
eurjchem-371	227	9	calculate	calculate	VERB
eurjchem-371	227	10	the	the	DET
eurjchem-371	227	11	percentage	percentage	NOUN
eurjchem-371	227	12	concentration	concentration	NOUN
eurjchem-371	227	13	of	of	ADP
eurjchem-371	227	14	protonated	protonate	VERB
eurjchem-371	227	15	species	specie	NOUN
eurjchem-371	227	16	at	at	ADP
eurjchem-371	227	17	three	three	NUM
eurjchem-371	227	18	relevant	relevant	ADJ
eurjchem-371	227	19	ph	ph	ADJ
eurjchem-371	227	20	values	value	NOUN
eurjchem-371	227	21	in	in	ADP
eurjchem-371	227	22	the	the	DET
eurjchem-371	227	23	body	body	NOUN
eurjchem-371	227	24	.	.	PUNCT
eurjchem-371	228	1	the	the	DET
eurjchem-371	228	2	ph	ph	ADJ
eurjchem-371	228	3	partition	partition	NOUN
eurjchem-371	228	4	hypothesis	hypothesis	NOUN
eurjchem-371	228	5	considers	consider	VERB
eurjchem-371	228	6	the	the	DET
eurjchem-371	228	7	non‐	non‐	NOUN
eurjchem-371	228	8	ionized	ionized	ADJ
eurjchem-371	228	9	,	,	PUNCT
eurjchem-371	228	10	neutral	neutral	ADJ
eurjchem-371	228	11	species	specie	NOUN
eurjchem-371	228	12	(	(	PUNCT
eurjchem-371	228	13	at	at	ADP
eurjchem-371	228	14	base	base	NOUN
eurjchem-371	228	15	:	:	PUNCT
eurjchem-371	228	16	b	b	X
eurjchem-371	228	17	,	,	PUNCT
eurjchem-371	228	18	at	at	ADP
eurjchem-371	228	19	acid	acid	NOUN
eurjchem-371	228	20	:	:	PUNCT
eurjchem-371	228	21	ah	ah	INTJ
eurjchem-371	228	22	)	)	PUNCT
eurjchem-371	228	23	to	to	PART
eurjchem-371	228	24	be	be	AUX
eurjchem-371	228	25	favourable	favourable	ADJ
eurjchem-371	228	26	for	for	SCONJ
eurjchem-371	228	27	the	the	DET
eurjchem-371	228	28	absorption	absorption	NOUN
eurjchem-371	228	29	using	use	VERB
eurjchem-371	228	30	passive	passive	ADJ
eurjchem-371	228	31	transport	transport	NOUN
eurjchem-371	228	32	through	through	ADP
eurjchem-371	228	33	the	the	DET
eurjchem-371	228	34	lipoid	lipoid	ADJ
eurjchem-371	228	35	membranes	membrane	NOUN
eurjchem-371	228	36	.	.	PUNCT
eurjchem-371	229	1	though	though	SCONJ
eurjchem-371	229	2	all	all	DET
eurjchem-371	229	3	the	the	DET
eurjchem-371	229	4	basic	basic	ADJ
eurjchem-371	229	5	compounds	compound	NOUN
eurjchem-371	229	6	are	be	AUX
eurjchem-371	229	7	predominantly	predominantly	ADV
eurjchem-371	229	8	present	present	ADJ
eurjchem-371	229	9	in	in	ADP
eurjchem-371	229	10	ionized	ionized	ADJ
eurjchem-371	229	11	(	(	PUNCT
eurjchem-371	229	12	bh+	bh+	NOUN
eurjchem-371	229	13	)	)	PUNCT
eurjchem-371	229	14	form	form	NOUN
eurjchem-371	229	15	in	in	ADP
eurjchem-371	229	16	different	different	ADJ
eurjchem-371	229	17	compartments	compartment	NOUN
eurjchem-371	229	18	,	,	PUNCT
eurjchem-371	229	19	38	38	NUM
eurjchem-371	229	20	%	%	NOUN
eurjchem-371	229	21	,	,	PUNCT
eurjchem-371	229	22	8.2	8.2	NUM
eurjchem-371	229	23	%	%	NOUN
eurjchem-371	229	24	and	and	CCONJ
eurjchem-371	229	25	15.16	15.16	NUM
eurjchem-371	229	26	%	%	NOUN
eurjchem-371	229	27	of	of	ADP
eurjchem-371	229	28	pro	pro	ADJ
eurjchem-371	229	29	,	,	PUNCT
eurjchem-371	229	30	mt	mt	PROPN
eurjchem-371	229	31	and	and	CCONJ
eurjchem-371	229	32	ab	ab	PROPN
eurjchem-371	229	33	neutral	neutral	ADJ
eurjchem-371	229	34	form	form	NOUN
eurjchem-371	229	35	(	(	PUNCT
eurjchem-371	229	36	b	b	NOUN
eurjchem-371	229	37	)	)	PUNCT
eurjchem-371	229	38	is	be	AUX
eurjchem-371	229	39	present	present	ADJ
eurjchem-371	229	40	in	in	ADP
eurjchem-371	229	41	the	the	DET
eurjchem-371	229	42	jejunum	jejunum	NOUN
eurjchem-371	229	43	.	.	PUNCT
eurjchem-371	230	1	however	however	ADV
eurjchem-371	230	2	,	,	PUNCT
eurjchem-371	230	3	all	all	DET
eurjchem-371	230	4	the	the	DET
eurjchem-371	230	5	basic	basic	ADJ
eurjchem-371	230	6	compounds	compound	NOUN
eurjchem-371	230	7	selected	select	VERB
eurjchem-371	230	8	in	in	ADP
eurjchem-371	230	9	the	the	DET
eurjchem-371	230	10	present	present	ADJ
eurjchem-371	230	11	study	study	NOUN
eurjchem-371	230	12	,	,	PUNCT
eurjchem-371	230	13	neutral	neutral	ADJ
eurjchem-371	230	14	form	form	NOUN
eurjchem-371	230	15	ranging	range	VERB
eurjchem-371	230	16	between	between	ADP
eurjchem-371	230	17	2.2	2.2	NUM
eurjchem-371	230	18	%	%	NOUN
eurjchem-371	230	19	and	and	CCONJ
eurjchem-371	230	20	58.5	58.5	NUM
eurjchem-371	230	21	%	%	NOUN
eurjchem-371	230	22	is	be	AUX
eurjchem-371	230	23	found	find	VERB
eurjchem-371	230	24	to	to	PART
eurjchem-371	230	25	be	be	AUX
eurjchem-371	230	26	present	present	ADJ
eurjchem-371	230	27	in	in	ADP
eurjchem-371	230	28	the	the	DET
eurjchem-371	230	29	plasma	plasma	NOUN
eurjchem-371	230	30	.	.	PUNCT
eurjchem-371	231	1	the	the	DET
eurjchem-371	231	2	acid	acid	PROPN
eurjchem-371	231	3	compounds	compound	NOUN
eurjchem-371	231	4	are	be	AUX
eurjchem-371	231	5	exceptional	exceptional	ADJ
eurjchem-371	231	6	within	within	ADP
eurjchem-371	231	7	the	the	DET
eurjchem-371	231	8	selected	select	VERB
eurjchem-371	231	9	compounds	compound	NOUN
eurjchem-371	231	10	because	because	SCONJ
eurjchem-371	231	11	its	its	PRON
eurjchem-371	231	12	neutral	neutral	ADJ
eurjchem-371	231	13	form	form	NOUN
eurjchem-371	231	14	(	(	PUNCT
eurjchem-371	231	15	ah	ah	INTJ
eurjchem-371	231	16	)	)	PUNCT
eurjchem-371	231	17	is	be	AUX
eurjchem-371	231	18	dominant	dominant	ADJ
eurjchem-371	231	19	in	in	ADP
eurjchem-371	231	20	all	all	DET
eurjchem-371	231	21	three	three	NUM
eurjchem-371	231	22	compartments	compartment	NOUN
eurjchem-371	231	23	of	of	ADP
eurjchem-371	231	24	the	the	DET
eurjchem-371	231	25	human	human	ADJ
eurjchem-371	231	26	body	body	NOUN
eurjchem-371	231	27	,	,	PUNCT
eurjchem-371	231	28	although	although	SCONJ
eurjchem-371	231	29	up	up	ADP
eurjchem-371	231	30	to	to	PART
eurjchem-371	231	31	41	41	NUM
eurjchem-371	231	32	%	%	NOUN
eurjchem-371	231	33	of	of	ADP
eurjchem-371	231	34	ionized	ionized	ADJ
eurjchem-371	231	35	species	specie	NOUN
eurjchem-371	231	36	is	be	AUX
eurjchem-371	231	37	found	find	VERB
eurjchem-371	231	38	to	to	PART
eurjchem-371	231	39	be	be	AUX
eurjchem-371	231	40	present	present	ADJ
eurjchem-371	231	41	in	in	ADP
eurjchem-371	231	42	plasma	plasma	NOUN
eurjchem-371	231	43	.	.	PUNCT
eurjchem-371	232	1	results	result	NOUN
eurjchem-371	232	2	are	be	AUX
eurjchem-371	232	3	summarized	summarize	VERB
eurjchem-371	232	4	in	in	ADP
eurjchem-371	232	5	table	table	NOUN
eurjchem-371	232	6	7	7	NUM
eurjchem-371	232	7	.	.	PUNCT
eurjchem-371	233	1	3.1.2	3.1.2	NUM
eurjchem-371	233	2	.	.	PUNCT
eurjchem-371	233	3	spectrophotometry	spectrophotometry	NOUN
eurjchem-371	233	4	out	out	ADP
eurjchem-371	233	5	of	of	ADP
eurjchem-371	233	6	all	all	DET
eurjchem-371	233	7	the	the	DET
eurjchem-371	233	8	selected	select	VERB
eurjchem-371	233	9	drugs	drug	NOUN
eurjchem-371	233	10	of	of	ADP
eurjchem-371	233	11	the	the	DET
eurjchem-371	233	12	present	present	ADJ
eurjchem-371	233	13	study	study	NOUN
eurjchem-371	233	14	,	,	PUNCT
eurjchem-371	233	15	only	only	ADV
eurjchem-371	233	16	aml	aml	PROPN
eurjchem-371	233	17	,	,	PUNCT
eurjchem-371	233	18	pro	pro	ADJ
eurjchem-371	233	19	,	,	PUNCT
eurjchem-371	233	20	atn	atn	PROPN
eurjchem-371	233	21	and	and	CCONJ
eurjchem-371	233	22	glc	glc	PROPN
eurjchem-371	233	23	is	be	AUX
eurjchem-371	233	24	found	find	VERB
eurjchem-371	233	25	to	to	PART
eurjchem-371	233	26	produce	produce	VERB
eurjchem-371	233	27	reasonable	reasonable	ADJ
eurjchem-371	233	28	absorption	absorption	NOUN
eurjchem-371	233	29	spectra	spectra	NOUN
eurjchem-371	233	30	with	with	ADP
eurjchem-371	233	31	the	the	DET
eurjchem-371	233	32	change	change	NOUN
eurjchem-371	233	33	in	in	ADP
eurjchem-371	233	34	ph	ph	PROPN
eurjchem-371	233	35	.	.	PROPN
eurjchem-371	233	36	among	among	ADP
eurjchem-371	233	37	the	the	DET
eurjchem-371	233	38	selected	select	VERB
eurjchem-371	233	39	drugs	drug	NOUN
eurjchem-371	233	40	for	for	ADP
eurjchem-371	233	41	the	the	DET
eurjchem-371	233	42	spectrophotometric	spectrophotometric	ADJ
eurjchem-371	233	43	study	study	NOUN
eurjchem-371	233	44	,	,	PUNCT
eurjchem-371	233	45	aml	aml	PROPN
eurjchem-371	233	46	has	have	AUX
eurjchem-371	233	47	exhibited	exhibit	VERB
eurjchem-371	233	48	excellent	excellent	ADJ
eurjchem-371	233	49	absorption	absorption	NOUN
eurjchem-371	233	50	spectra	spectra	NOUN
eurjchem-371	233	51	with	with	ADP
eurjchem-371	233	52	the	the	DET
eurjchem-371	233	53	changes	change	NOUN
eurjchem-371	233	54	in	in	ADP
eurjchem-371	233	55	ph	ph	NOUN
eurjchem-371	233	56	,	,	PUNCT
eurjchem-371	233	57	as	as	SCONJ
eurjchem-371	233	58	shown	show	VERB
eurjchem-371	233	59	in	in	ADP
eurjchem-371	233	60	figure	figure	NOUN
eurjchem-371	233	61	7	7	NUM
eurjchem-371	233	62	.	.	PUNCT
eurjchem-371	234	1	this	this	PRON
eurjchem-371	234	2	can	can	AUX
eurjchem-371	234	3	be	be	AUX
eurjchem-371	234	4	explained	explain	VERB
eurjchem-371	234	5	by	by	ADP
eurjchem-371	234	6	the	the	DET
eurjchem-371	234	7	fact	fact	NOUN
eurjchem-371	234	8	that	that	SCONJ
eurjchem-371	234	9	,	,	PUNCT
eurjchem-371	234	10	in	in	ADP
eurjchem-371	234	11	case	case	NOUN
eurjchem-371	234	12	of	of	ADP
eurjchem-371	234	13	aml	aml	NOUN
eurjchem-371	234	14	,	,	PUNCT
eurjchem-371	234	15	ionisable	ionisable	ADJ
eurjchem-371	234	16	–	–	PUNCT
eurjchem-371	234	17	nh	nh	NOUN
eurjchem-371	234	18	group	group	NOUN
eurjchem-371	234	19	of	of	ADP
eurjchem-371	234	20	guanidine	guanidine	ADJ
eurjchem-371	234	21	moiety	moiety	NOUN
eurjchem-371	234	22	is	be	AUX
eurjchem-371	234	23	part	part	NOUN
eurjchem-371	234	24	of	of	ADP
eurjchem-371	234	25	the	the	DET
eurjchem-371	234	26	system	system	NOUN
eurjchem-371	234	27	of	of	ADP
eurjchem-371	234	28	conjugated	conjugated	ADJ
eurjchem-371	234	29	double	double	ADJ
eurjchem-371	234	30	bond	bond	NOUN
eurjchem-371	234	31	.	.	PUNCT
eurjchem-371	235	1	target	target	NOUN
eurjchem-371	235	2	factor	factor	NOUN
eurjchem-371	235	3	analysis	analysis	NOUN
eurjchem-371	235	4	(	(	PUNCT
eurjchem-371	235	5	tfa	tfa	NOUN
eurjchem-371	235	6	)	)	PUNCT
eurjchem-371	235	7	has	have	AUX
eurjchem-371	235	8	been	be	AUX
eurjchem-371	235	9	applied	apply	VERB
eurjchem-371	235	10	to	to	PART
eurjchem-371	235	11	deduce	deduce	VERB
eurjchem-371	235	12	the	the	DET
eurjchem-371	235	13	pka	pka	PROPN
eurjchem-371	235	14	values	value	NOUN
eurjchem-371	235	15	from	from	ADP
eurjchem-371	235	16	the	the	DET
eurjchem-371	235	17	multi	multi	ADJ
eurjchem-371	235	18	wavelength	wavelength	NOUN
eurjchem-371	235	19	uv	uv	NOUN
eurjchem-371	235	20	absorption	absorption	NOUN
eurjchem-371	235	21	data	datum	NOUN
eurjchem-371	235	22	recorded	record	VERB
eurjchem-371	235	23	at	at	ADP
eurjchem-371	235	24	different	different	ADJ
eurjchem-371	235	25	ph	ph	ADJ
eurjchem-371	235	26	values	value	NOUN
eurjchem-371	235	27	.	.	PUNCT
eurjchem-371	236	1	results	result	NOUN
eurjchem-371	236	2	are	be	AUX
eurjchem-371	236	3	shown	show	VERB
eurjchem-371	236	4	in	in	ADP
eurjchem-371	236	5	table	table	NOUN
eurjchem-371	236	6	2	2	NUM
eurjchem-371	236	7	.	.	PUNCT
eurjchem-371	236	8	results	result	NOUN
eurjchem-371	236	9	indicate	indicate	VERB
eurjchem-371	236	10	that	that	SCONJ
eurjchem-371	236	11	the	the	DET
eurjchem-371	236	12	extrapolated	extrapolated	ADJ
eurjchem-371	236	13	pka	pka	PROPN
eurjchem-371	236	14	values	value	NOUN
eurjchem-371	236	15	by	by	ADP
eurjchem-371	236	16	ys	ys	NOUN
eurjchem-371	236	17	method	method	NOUN
eurjchem-371	236	18	is	be	AUX
eurjchem-371	236	19	in	in	ADP
eurjchem-371	236	20	good	good	ADJ
eurjchem-371	236	21	agreement	agreement	NOUN
eurjchem-371	236	22	with	with	ADP
eurjchem-371	236	23	the	the	DET
eurjchem-371	236	24	ph	ph	ADJ
eurjchem-371	236	25	metry‐aqueous	metry‐aqueous	ADJ
eurjchem-371	236	26	pka	pka	PROPN
eurjchem-371	236	27	values	value	NOUN
eurjchem-371	236	28	.	.	PUNCT
eurjchem-371	237	1	the	the	DET
eurjchem-371	237	2	spectrophoto‐	spectrophoto‐	PROPN
eurjchem-371	237	3	metric	metric	ADJ
eurjchem-371	237	4	results	result	NOUN
eurjchem-371	237	5	containing	contain	VERB
eurjchem-371	237	6	distribution	distribution	NOUN
eurjchem-371	237	7	of	of	ADP
eurjchem-371	237	8	species	specie	NOUN
eurjchem-371	237	9	and	and	CCONJ
eurjchem-371	237	10	spectral	spectral	ADJ
eurjchem-371	237	11	absorbance	absorbance	NOUN
eurjchem-371	237	12	change	change	VERB
eurjchem-371	237	13	with	with	ADP
eurjchem-371	237	14	ph	ph	NOUN
eurjchem-371	237	15	for	for	ADP
eurjchem-371	237	16	aml	aml	NOUN
eurjchem-371	237	17	,	,	PUNCT
eurjchem-371	237	18	pro	pro	ADJ
eurjchem-371	237	19	,	,	PUNCT
eurjchem-371	237	20	atn	atn	PROPN
eurjchem-371	237	21	and	and	CCONJ
eurjchem-371	237	22	glc	glc	PROPN
eurjchem-371	237	23	are	be	AUX
eurjchem-371	237	24	presented	present	VERB
eurjchem-371	237	25	in	in	ADP
eurjchem-371	237	26	figure	figure	NOUN
eurjchem-371	237	27	8a	8a	NUM
eurjchem-371	237	28	to	to	ADP
eurjchem-371	237	29	8h	8h	PROPN
eurjchem-371	237	30	.	.	PROPN
eurjchem-371	238	1	3.2	3.2	NUM
eurjchem-371	238	2	.	.	PUNCT
eurjchem-371	238	3	lipophilicity	lipophilicity	NOUN
eurjchem-371	238	4	the	the	DET
eurjchem-371	238	5	log	log	NOUN
eurjchem-371	238	6	poct	poct	NOUN
eurjchem-371	238	7	values	value	NOUN
eurjchem-371	238	8	were	be	AUX
eurjchem-371	238	9	measured	measure	VERB
eurjchem-371	238	10	by	by	ADP
eurjchem-371	238	11	dual	dual	ADJ
eurjchem-371	238	12	phase	phase	NOUN
eurjchem-371	238	13	potentiometric	potentiometric	ADJ
eurjchem-371	238	14	titration	titration	NOUN
eurjchem-371	238	15	.	.	PUNCT
eurjchem-371	239	1	this	this	DET
eurjchem-371	239	2	method	method	NOUN
eurjchem-371	239	3	,	,	PUNCT
eurjchem-371	239	4	being	be	AUX
eurjchem-371	239	5	fast	fast	ADJ
eurjchem-371	239	6	,	,	PUNCT
eurjchem-371	239	7	precise	precise	ADJ
eurjchem-371	239	8	and	and	CCONJ
eurjchem-371	239	9	automated	automate	VERB
eurjchem-371	239	10	,	,	PUNCT
eurjchem-371	239	11	is	be	AUX
eurjchem-371	239	12	considered	consider	VERB
eurjchem-371	239	13	as	as	ADP
eurjchem-371	239	14	the	the	DET
eurjchem-371	239	15	“	"	PUNCT
eurjchem-371	239	16	gold	gold	NOUN
eurjchem-371	239	17	standard	standard	NOUN
eurjchem-371	239	18	”	"	PUNCT
eurjchem-371	239	19	of	of	ADP
eurjchem-371	239	20	log	log	NOUN
eurjchem-371	239	21	p	p	NOUN
eurjchem-371	239	22	determination	determination	NOUN
eurjchem-371	239	23	[	[	X
eurjchem-371	239	24	35	35	NUM
eurjchem-371	239	25	]	]	PUNCT
eurjchem-371	239	26	,	,	PUNCT
eurjchem-371	239	27	and	and	CCONJ
eurjchem-371	239	28	it	it	PRON
eurjchem-371	239	29	can	can	AUX
eurjchem-371	239	30	be	be	AUX
eurjchem-371	239	31	used	use	VERB
eurjchem-371	239	32	for	for	ADP
eurjchem-371	239	33	log	log	NOUN
eurjchem-371	239	34	p	p	NOUN
eurjchem-371	239	35	measurements	measurement	NOUN
eurjchem-371	239	36	even	even	ADV
eurjchem-371	239	37	for	for	ADP
eurjchem-371	239	38	compounds	compound	NOUN
eurjchem-371	239	39	of	of	ADP
eurjchem-371	239	40	high	high	ADJ
eurjchem-371	239	41	lipophilicity	lipophilicity	NOUN
eurjchem-371	239	42	.	.	PUNCT
eurjchem-371	240	1	typically	typically	ADV
eurjchem-371	240	2	compounds	compound	VERB
eurjchem-371	240	3	partition	partition	NOUN
eurjchem-371	240	4	to	to	ADP
eurjchem-371	240	5	a	a	DET
eurjchem-371	240	6	much	much	ADV
eurjchem-371	240	7	greater	great	ADJ
eurjchem-371	240	8	extent	extent	NOUN
eurjchem-371	240	9	in	in	ADP
eurjchem-371	240	10	their	their	PRON
eurjchem-371	240	11	neutral	neutral	ADJ
eurjchem-371	240	12	form	form	NOUN
eurjchem-371	240	13	than	than	ADP
eurjchem-371	240	14	their	their	PRON
eurjchem-371	240	15	ionized	ionized	ADJ
eurjchem-371	240	16	form	form	NOUN
eurjchem-371	240	17	,	,	PUNCT
eurjchem-371	240	18	hence	hence	ADV
eurjchem-371	240	19	a	a	DET
eurjchem-371	240	20	larger	large	ADJ
eurjchem-371	240	21	portion	portion	NOUN
eurjchem-371	240	22	of	of	ADP
eurjchem-371	240	23	the	the	DET
eurjchem-371	240	24	neutral	neutral	ADJ
eurjchem-371	240	25	species	specie	NOUN
eurjchem-371	240	26	will	will	AUX
eurjchem-371	240	27	disappear	disappear	VERB
eurjchem-371	240	28	into	into	ADP
eurjchem-371	240	29	the	the	DET
eurjchem-371	240	30	octanol	octanol	NOUN
eurjchem-371	240	31	phase	phase	NOUN
eurjchem-371	240	32	.	.	PUNCT
eurjchem-371	241	1	since	since	SCONJ
eurjchem-371	241	2	high	high	ADJ
eurjchem-371	241	3	log	log	NOUN
eurjchem-371	241	4	poct	poct	NOUN
eurjchem-371	241	5	values	value	NOUN
eurjchem-371	241	6	were	be	AUX
eurjchem-371	241	7	expected	expect	VERB
eurjchem-371	241	8	,	,	PUNCT
eurjchem-371	241	9	especially	especially	ADV
eurjchem-371	241	10	for	for	ADP
eurjchem-371	241	11	glb	glb	NOUN
eurjchem-371	241	12	and	and	CCONJ
eurjchem-371	241	13	pro	pro	ADJ
eurjchem-371	241	14	,	,	PUNCT
eurjchem-371	241	15	small	small	ADJ
eurjchem-371	241	16	amounts	amount	NOUN
eurjchem-371	241	17	of	of	ADP
eurjchem-371	241	18	octanol	octanol	NOUN
eurjchem-371	241	19	was	be	AUX
eurjchem-371	241	20	applied	apply	VERB
eurjchem-371	241	21	during	during	ADP
eurjchem-371	241	22	the	the	DET
eurjchem-371	241	23	titration	titration	NOUN
eurjchem-371	241	24	.	.	PUNCT
eurjchem-371	242	1	figure	figure	NOUN
eurjchem-371	242	2	9	9	NUM
eurjchem-371	242	3	represents	represent	VERB
eurjchem-371	242	4	the	the	DET
eurjchem-371	242	5	typical	typical	ADJ
eurjchem-371	242	6	shift	shift	NOUN
eurjchem-371	242	7	of	of	ADP
eurjchem-371	242	8	bjerrum	bjerrum	NOUN
eurjchem-371	242	9	curve	curve	NOUN
eurjchem-371	242	10	during	during	ADP
eurjchem-371	242	11	the	the	DET
eurjchem-371	242	12	course	course	NOUN
eurjchem-371	242	13	of	of	ADP
eurjchem-371	242	14	titration	titration	NOUN
eurjchem-371	242	15	in	in	ADP
eurjchem-371	242	16	presence	presence	NOUN
eurjchem-371	242	17	of	of	ADP
eurjchem-371	242	18	octanol	octanol	NOUN
eurjchem-371	242	19	for	for	ADP
eurjchem-371	242	20	all	all	DET
eurjchem-371	242	21	the	the	DET
eurjchem-371	242	22	compounds	compound	NOUN
eurjchem-371	242	23	studied	study	VERB
eurjchem-371	242	24	in	in	ADP
eurjchem-371	242	25	the	the	DET
eurjchem-371	242	26	present	present	ADJ
eurjchem-371	242	27	investigation	investigation	NOUN
eurjchem-371	242	28	.	.	PUNCT
eurjchem-371	243	1	from	from	ADP
eurjchem-371	243	2	these	these	DET
eurjchem-371	243	3	titrations	titration	NOUN
eurjchem-371	243	4	,	,	PUNCT
eurjchem-371	243	5	the	the	DET
eurjchem-371	243	6	apparent	apparent	ADJ
eurjchem-371	243	7	ionization	ionization	NOUN
eurjchem-371	243	8	constants	constant	NOUN
eurjchem-371	243	9	(	(	PUNCT
eurjchem-371	243	10	poka	poka	NOUN
eurjchem-371	243	11	)	)	PUNCT
eurjchem-371	243	12	were	be	AUX
eurjchem-371	243	13	calculated	calculate	VERB
eurjchem-371	243	14	.	.	PUNCT
eurjchem-371	244	1	the	the	DET
eurjchem-371	244	2	log	log	NOUN
eurjchem-371	244	3	p	p	NOUN
eurjchem-371	244	4	values	value	NOUN
eurjchem-371	244	5	for	for	ADP
eurjchem-371	244	6	acids	acid	NOUN
eurjchem-371	244	7	and	and	CCONJ
eurjchem-371	244	8	bases	basis	NOUN
eurjchem-371	244	9	were	be	AUX
eurjchem-371	244	10	then	then	ADV
eurjchem-371	244	11	calculated	calculate	VERB
eurjchem-371	244	12	using	use	VERB
eurjchem-371	244	13	eq	eq	ADP
eurjchem-371	244	14	.	.	PROPN
eurjchem-371	244	15	3	3	NUM
eurjchem-371	244	16	and	and	CCONJ
eurjchem-371	244	17	4	4	NUM
eurjchem-371	244	18	,	,	PUNCT
eurjchem-371	244	19	respectively	respectively	ADV
eurjchem-371	244	20	.	.	PUNCT
eurjchem-371	245	1	acid	acid	NOUN
eurjchem-371	245	2	with	with	ADP
eurjchem-371	245	3	one	one	NUM
eurjchem-371	245	4	pka	pka	PROPN
eurjchem-371	245	5	∶	∶	NOUN
eurjchem-371	245	6	p	p	ADJ
eurjchem-371	245	7	10	10	NUM
eurjchem-371	245	8	pka	pka	NOUN
eurjchem-371	245	9	poka	poka	NOUN
eurjchem-371	245	10	1	1	NUM
eurjchem-371	245	11	(	(	PUNCT
eurjchem-371	245	12	3	3	NUM
eurjchem-371	245	13	)	)	PUNCT
eurjchem-371	245	14	base	base	NOUN
eurjchem-371	245	15	with	with	ADP
eurjchem-371	245	16	one	one	NUM
eurjchem-371	245	17	pka	pka	PROPN
eurjchem-371	245	18	∶	∶	NOUN
eurjchem-371	245	19	p	p	ADJ
eurjchem-371	245	20	10	10	NUM
eurjchem-371	245	21	poka	poka	NOUN
eurjchem-371	245	22	pka	pka	PROPN
eurjchem-371	245	23	1	1	NUM
eurjchem-371	245	24	(	(	PUNCT
eurjchem-371	245	25	4	4	NUM
eurjchem-371	245	26	)	)	PUNCT
eurjchem-371	245	27	where	where	SCONJ
eurjchem-371	245	28	r	r	NOUN
eurjchem-371	245	29	is	be	AUX
eurjchem-371	245	30	the	the	DET
eurjchem-371	245	31	volume	volume	NOUN
eurjchem-371	245	32	ratio	ratio	NOUN
eurjchem-371	245	33	of	of	ADP
eurjchem-371	245	34	octanol	octanol	NOUN
eurjchem-371	245	35	to	to	AUX
eurjchem-371	245	36	water	water	NOUN
eurjchem-371	245	37	.	.	PUNCT
eurjchem-371	246	1	the	the	DET
eurjchem-371	246	2	experimental	experimental	ADJ
eurjchem-371	246	3	log	log	NOUN
eurjchem-371	246	4	p	p	NOUN
eurjchem-371	246	5	values	value	NOUN
eurjchem-371	246	6	obtained	obtain	VERB
eurjchem-371	246	7	by	by	ADP
eurjchem-371	246	8	potentiometric	potentiometric	NOUN
eurjchem-371	246	9	and	and	CCONJ
eurjchem-371	246	10	hplc	hplc	NOUN
eurjchem-371	246	11	methods	method	NOUN
eurjchem-371	246	12	are	be	AUX
eurjchem-371	246	13	given	give	VERB
eurjchem-371	246	14	in	in	ADP
eurjchem-371	246	15	table	table	NOUN
eurjchem-371	246	16	8	8	NUM
eurjchem-371	246	17	.	.	PUNCT
eurjchem-371	247	1	on	on	ADP
eurjchem-371	247	2	the	the	DET
eurjchem-371	247	3	close	close	ADJ
eurjchem-371	247	4	examination	examination	NOUN
eurjchem-371	247	5	of	of	ADP
eurjchem-371	247	6	bjerrum	bjerrum	NOUN
eurjchem-371	247	7	curves	curve	NOUN
eurjchem-371	247	8	of	of	ADP
eurjchem-371	247	9	all	all	DET
eurjchem-371	247	10	the	the	DET
eurjchem-371	247	11	compounds	compound	NOUN
eurjchem-371	247	12	,	,	PUNCT
eurjchem-371	247	13	it	it	PRON
eurjchem-371	247	14	is	be	AUX
eurjchem-371	247	15	evident	evident	ADJ
eurjchem-371	247	16	that	that	SCONJ
eurjchem-371	247	17	all	all	DET
eurjchem-371	247	18	the	the	DET
eurjchem-371	247	19	compounds	compound	NOUN
eurjchem-371	247	20	belonging	belong	VERB
eurjchem-371	247	21	to	to	ADP
eurjchem-371	247	22	beta	beta	NOUN
eurjchem-371	247	23	blocker	blocker	NOUN
eurjchem-371	247	24	class	class	NOUN
eurjchem-371	247	25	(	(	PUNCT
eurjchem-371	247	26	aml	aml	PROPN
eurjchem-371	247	27	,	,	PUNCT
eurjchem-371	247	28	pro	pro	ADJ
eurjchem-371	247	29	,	,	PUNCT
eurjchem-371	247	30	atn	atn	PROPN
eurjchem-371	247	31	,	,	PUNCT
eurjchem-371	247	32	mt	mt	PROPN
eurjchem-371	247	33	and	and	CCONJ
eurjchem-371	247	34	ab	ab	PROPN
eurjchem-371	247	35	)	)	PUNCT
eurjchem-371	247	36	is	be	AUX
eurjchem-371	247	37	bases	basis	NOUN
eurjchem-371	247	38	as	as	ADV
eurjchem-371	247	39	all	all	DET
eurjchem-371	247	40	the	the	DET
eurjchem-371	247	41	measured	measured	ADJ
eurjchem-371	247	42	apparent	apparent	ADJ
eurjchem-371	247	43	pka	pka	NOUN
eurjchem-371	247	44	(	(	PUNCT
eurjchem-371	247	45	poka	poka	NOUN
eurjchem-371	247	46	)	)	PUNCT
eurjchem-371	247	47	values	value	NOUN
eurjchem-371	247	48	shifted	shift	VERB
eurjchem-371	247	49	to	to	ADP
eurjchem-371	247	50	lower	low	ADJ
eurjchem-371	247	51	ph	ph	ADJ
eurjchem-371	247	52	values	value	NOUN
eurjchem-371	247	53	from	from	ADP
eurjchem-371	247	54	their	their	PRON
eurjchem-371	247	55	aqueous	aqueous	ADJ
eurjchem-371	247	56	pka	pka	NOUN
eurjchem-371	247	57	values	value	NOUN
eurjchem-371	247	58	.	.	PUNCT
eurjchem-371	248	1	in	in	ADP
eurjchem-371	248	2	the	the	DET
eurjchem-371	248	3	case	case	NOUN
eurjchem-371	248	4	of	of	ADP
eurjchem-371	248	5	glc	glc	PROPN
eurjchem-371	248	6	,	,	PUNCT
eurjchem-371	248	7	glb	glb	NOUN
eurjchem-371	248	8	and	and	CCONJ
eurjchem-371	248	9	glz	glz	PROPN
eurjchem-371	248	10	(	(	PUNCT
eurjchem-371	248	11	all	all	DET
eurjchem-371	248	12	anti‐diabetics	anti‐diabetic	NOUN
eurjchem-371	248	13	)	)	PUNCT
eurjchem-371	248	14	,	,	PUNCT
eurjchem-371	248	15	the	the	DET
eurjchem-371	248	16	poka	poka	NOUN
eurjchem-371	248	17	values	value	NOUN
eurjchem-371	248	18	shifted	shift	VERB
eurjchem-371	248	19	to	to	ADP
eurjchem-371	248	20	higher	high	ADJ
eurjchem-371	248	21	ph	ph	ADJ
eurjchem-371	248	22	values	value	NOUN
eurjchem-371	248	23	from	from	ADP
eurjchem-371	248	24	their	their	PRON
eurjchem-371	248	25	aqueous	aqueous	ADJ
eurjchem-371	248	26	pka	pka	NOUN
eurjchem-371	248	27	suggesting	suggest	VERB
eurjchem-371	248	28	that	that	SCONJ
eurjchem-371	248	29	these	these	DET
eurjchem-371	248	30	compounds	compound	NOUN
eurjchem-371	248	31	are	be	AUX
eurjchem-371	248	32	acids	acid	NOUN
eurjchem-371	248	33	.	.	PUNCT
eurjchem-371	249	1	figure	figure	NOUN
eurjchem-371	249	2	7	7	NUM
eurjchem-371	249	3	.	.	PUNCT
eurjchem-371	250	1	aml	aml	PROPN
eurjchem-371	250	2	–	–	PUNCT
eurjchem-371	250	3	spectral	spectral	ADJ
eurjchem-371	250	4	data	datum	NOUN
eurjchem-371	250	5	with	with	ADP
eurjchem-371	250	6	change	change	NOUN
eurjchem-371	250	7	in	in	ADP
eurjchem-371	250	8	ph	ph	PROPN
eurjchem-371	250	9	.	.	PROPN
eurjchem-371	250	10	44	44	NUM
eurjchem-371	250	11	narasimham	narasimham	PROPN
eurjchem-371	250	12	and	and	CCONJ
eurjchem-371	250	13	barhate	barhate	VERB
eurjchem-371	250	14	/	/	SYM
eurjchem-371	250	15	european	european	ADJ
eurjchem-371	250	16	journal	journal	PROPN
eurjchem-371	250	17	of	of	ADP
eurjchem-371	250	18	chemistry	chemistry	NOUN
eurjchem-371	250	19	2	2	NUM
eurjchem-371	250	20	(	(	PUNCT
eurjchem-371	250	21	1	1	NUM
eurjchem-371	250	22	)	)	PUNCT
eurjchem-371	250	23	(	(	PUNCT
eurjchem-371	250	24	2011	2011	NUM
eurjchem-371	250	25	)	)	PUNCT
eurjchem-371	250	26	36‐46	36‐46	NUM
eurjchem-371	250	27	figure	figure	NOUN
eurjchem-371	250	28	8	8	NUM
eurjchem-371	250	29	.	.	PUNCT
eurjchem-371	251	1	distribution	distribution	NOUN
eurjchem-371	251	2	of	of	ADP
eurjchem-371	251	3	species	specie	NOUN
eurjchem-371	251	4	and	and	CCONJ
eurjchem-371	251	5	spectral	spectral	ADJ
eurjchem-371	251	6	data	datum	NOUN
eurjchem-371	251	7	of	of	ADP
eurjchem-371	251	8	selected	select	VERB
eurjchem-371	251	9	drugs	drug	NOUN
eurjchem-371	251	10	.	.	PUNCT
eurjchem-371	252	1	table	table	NOUN
eurjchem-371	252	2	8	8	NUM
eurjchem-371	252	3	.	.	PUNCT
eurjchem-371	253	1	log	log	NOUN
eurjchem-371	253	2	p	p	NOUN
eurjchem-371	253	3	values	value	NOUN
eurjchem-371	253	4	obtained	obtain	VERB
eurjchem-371	253	5	by	by	ADP
eurjchem-371	253	6	potentiometric	potentiometric	NOUN
eurjchem-371	253	7	and	and	CCONJ
eurjchem-371	253	8	hplc	hplc	NOUN
eurjchem-371	253	9	methods	method	NOUN
eurjchem-371	253	10	.	.	PUNCT
eurjchem-371	254	1	therapeutical	therapeutical	ADJ
eurjchem-371	254	2	class	class	NOUN
eurjchem-371	254	3	compound	compound	PROPN
eurjchem-371	254	4	potentiometric	potentiometric	PROPN
eurjchem-371	254	5	hplc	hplc	PROPN
eurjchem-371	254	6	log	log	VERB
eurjchem-371	254	7	d	d	NOUN
eurjchem-371	254	8	7.4	7.4	NUM
eurjchem-371	254	9	literature	literature	NOUN
eurjchem-371	254	10	log	log	NOUN
eurjchem-371	254	11	pa	pa	PROPN
eurjchem-371	254	12	log	log	PROPN
eurjchem-371	254	13	p	p	PROPN
eurjchem-371	254	14	±	±	NOUN
eurjchem-371	254	15	rmsd	rmsd	NOUN
eurjchem-371	254	16	beta	beta	NOUN
eurjchem-371	254	17	blockers	blocker	NOUN
eurjchem-371	254	18	aml	aml	PROPN
eurjchem-371	254	19	0.04	0.04	NUM
eurjchem-371	254	20	±	±	NUM
eurjchem-371	254	21	0.18	0.18	NUM
eurjchem-371	254	22	0.16	0.16	NUM
eurjchem-371	254	23	0.09b	0.09b	NUM
eurjchem-371	254	24	pro	pro	NOUN
eurjchem-371	254	25	3.48	3.48	NUM
eurjchem-371	254	26	±	±	NUM
eurjchem-371	254	27	0.09	0.09	NUM
eurjchem-371	254	28	3.34	3.34	NUM
eurjchem-371	254	29	3.00	3.00	NUM
eurjchem-371	254	30	atn	atn	NOUN
eurjchem-371	254	31	0.28	0.28	NUM
eurjchem-371	254	32	±	±	NUM
eurjchem-371	254	33	0.07	0.07	NUM
eurjchem-371	254	34	0.32	0.32	NUM
eurjchem-371	254	35	0.50	0.50	NUM
eurjchem-371	254	36	mt	mt	PROPN
eurjchem-371	254	37	1.95	1.95	NUM
eurjchem-371	254	38	±	±	NUM
eurjchem-371	254	39	0.07	0.07	NUM
eurjchem-371	254	40	1.79	1.79	NUM
eurjchem-371	254	41	1.60	1.60	NUM
eurjchem-371	254	42	ab	ab	PROPN
eurjchem-371	254	43	3.39	3.39	NUM
eurjchem-371	254	44	±	±	NUM
eurjchem-371	254	45	0.07	0.07	NUM
eurjchem-371	254	46	3.28	3.28	NUM
eurjchem-371	254	47	1.90	1.90	NUM
eurjchem-371	254	48	anti‐diabetics	anti‐diabetic	NOUN
eurjchem-371	254	49	glc	glc	PROPN
eurjchem-371	254	50	2.07	2.07	NUM
eurjchem-371	254	51	±	±	NUM
eurjchem-371	254	52	0.07	0.07	NUM
eurjchem-371	254	53	2.18	2.18	NUM
eurjchem-371	254	54	2.60	2.60	NUM
eurjchem-371	254	55	glb	glb	NOUN
eurjchem-371	254	56	4.20	4.20	NUM
eurjchem-371	254	57	±	±	NUM
eurjchem-371	254	58	0.11	0.11	NUM
eurjchem-371	254	59	4.05	4.05	NUM
eurjchem-371	254	60	3.80	3.80	NUM
eurjchem-371	254	61	glz	glz	NOUN
eurjchem-371	254	62	2.35	2.35	NUM
eurjchem-371	254	63	±	±	NUM
eurjchem-371	254	64	0.16	0.16	NUM
eurjchem-371	254	65	2.27	2.27	NUM
eurjchem-371	254	66	2.50	2.50	NUM
eurjchem-371	254	67	a	a	DET
eurjchem-371	254	68	ref	ref	NOUN
eurjchem-371	254	69	.	.	PUNCT
eurjchem-371	255	1	[	[	X
eurjchem-371	255	2	30	30	NUM
eurjchem-371	255	3	]	]	SYM
eurjchem-371	255	4	.	.	PUNCT
eurjchem-371	256	1	b	b	X
eurjchem-371	256	2	phenomenex	phenomenex	ADV
eurjchem-371	256	3	dmpk	dmpk	NOUN
eurjchem-371	256	4	guide	guide	NOUN
eurjchem-371	256	5	.	.	PUNCT
eurjchem-371	257	1	narasimham	narasimham	PROPN
eurjchem-371	257	2	and	and	CCONJ
eurjchem-371	257	3	barhate	barhate	VERB
eurjchem-371	257	4	/	/	SYM
eurjchem-371	257	5	european	european	ADJ
eurjchem-371	257	6	journal	journal	PROPN
eurjchem-371	257	7	of	of	ADP
eurjchem-371	257	8	chemistry	chemistry	NOUN
eurjchem-371	257	9	2	2	NUM
eurjchem-371	257	10	(	(	PUNCT
eurjchem-371	257	11	1	1	NUM
eurjchem-371	257	12	)	)	PUNCT
eurjchem-371	257	13	(	(	PUNCT
eurjchem-371	257	14	2011	2011	NUM
eurjchem-371	257	15	)	)	PUNCT
eurjchem-371	257	16	36‐46	36‐46	NOUN
eurjchem-371	257	17	45	45	NUM
eurjchem-371	257	18	figure	figure	NOUN
eurjchem-371	257	19	9	9	NUM
eurjchem-371	257	20	.	.	PUNCT
eurjchem-371	258	1	log	log	VERB
eurjchem-371	258	2	p	p	NOUN
eurjchem-371	258	3	‐	‐	ADJ
eurjchem-371	258	4	bjerrum	bjerrum	NOUN
eurjchem-371	258	5	curves	curve	NOUN
eurjchem-371	258	6	for	for	ADP
eurjchem-371	258	7	selected	select	VERB
eurjchem-371	258	8	compounds	compound	NOUN
eurjchem-371	258	9	.	.	PUNCT
eurjchem-371	259	1	a	a	DET
eurjchem-371	259	2	plot	plot	NOUN
eurjchem-371	259	3	of	of	ADP
eurjchem-371	259	4	log	log	NOUN
eurjchem-371	259	5	k	k	NOUN
eurjchem-371	259	6	’	'	PUNCT
eurjchem-371	259	7	,	,	PUNCT
eurjchem-371	259	8	the	the	DET
eurjchem-371	259	9	chromatographic	chromatographic	ADJ
eurjchem-371	259	10	capacity	capacity	NOUN
eurjchem-371	259	11	factor	factor	NOUN
eurjchem-371	259	12	,	,	PUNCT
eurjchem-371	259	13	against	against	ADP
eurjchem-371	259	14	log	log	NOUN
eurjchem-371	259	15	p	p	NOUN
eurjchem-371	259	16	is	be	AUX
eurjchem-371	259	17	linear	linear	ADJ
eurjchem-371	259	18	and	and	CCONJ
eurjchem-371	259	19	the	the	DET
eurjchem-371	259	20	correlation	correlation	NOUN
eurjchem-371	259	21	co‐efficient	co‐efficient	NOUN
eurjchem-371	259	22	for	for	ADP
eurjchem-371	259	23	hplc	hplc	NOUN
eurjchem-371	259	24	log	log	NOUN
eurjchem-371	259	25	p	p	NOUN
eurjchem-371	259	26	measurement	measurement	NOUN
eurjchem-371	259	27	is	be	AUX
eurjchem-371	259	28	found	find	VERB
eurjchem-371	259	29	to	to	PART
eurjchem-371	259	30	be	be	AUX
eurjchem-371	259	31	0.9973	0.9973	NUM
eurjchem-371	259	32	.	.	PUNCT
eurjchem-371	260	1	close	close	ADJ
eurjchem-371	260	2	look	look	NOUN
eurjchem-371	260	3	at	at	ADP
eurjchem-371	260	4	the	the	DET
eurjchem-371	260	5	log	log	NOUN
eurjchem-371	260	6	p	p	NOUN
eurjchem-371	260	7	results	result	NOUN
eurjchem-371	260	8	between	between	ADP
eurjchem-371	260	9	potentiometry	potentiometry	NOUN
eurjchem-371	260	10	and	and	CCONJ
eurjchem-371	260	11	partition	partition	NOUN
eurjchem-371	260	12	hplc	hplc	NOUN
eurjchem-371	260	13	,	,	PUNCT
eurjchem-371	260	14	reveals	reveal	VERB
eurjchem-371	260	15	that	that	SCONJ
eurjchem-371	260	16	the	the	DET
eurjchem-371	260	17	values	value	NOUN
eurjchem-371	260	18	with	with	ADP
eurjchem-371	260	19	each	each	DET
eurjchem-371	260	20	technique	technique	NOUN
eurjchem-371	260	21	differ	differ	VERB
eurjchem-371	260	22	by	by	ADP
eurjchem-371	260	23	only	only	ADV
eurjchem-371	260	24	0.2	0.2	NUM
eurjchem-371	260	25	.	.	PUNCT
eurjchem-371	261	1	since	since	ADV
eurjchem-371	261	2	,	,	PUNCT
eurjchem-371	261	3	method	method	NOUN
eurjchem-371	261	4	adopted	adopt	VERB
eurjchem-371	261	5	for	for	ADP
eurjchem-371	261	6	the	the	DET
eurjchem-371	261	7	literature	literature	NOUN
eurjchem-371	261	8	values	value	NOUN
eurjchem-371	261	9	are	be	AUX
eurjchem-371	261	10	unknown	unknown	ADJ
eurjchem-371	261	11	,	,	PUNCT
eurjchem-371	261	12	it	it	PRON
eurjchem-371	261	13	is	be	AUX
eurjchem-371	261	14	obvious	obvious	ADJ
eurjchem-371	261	15	that	that	SCONJ
eurjchem-371	261	16	the	the	DET
eurjchem-371	261	17	values	value	NOUN
eurjchem-371	261	18	differ	differ	VERB
eurjchem-371	261	19	considerably	considerably	ADV
eurjchem-371	261	20	with	with	ADP
eurjchem-371	261	21	our	our	PRON
eurjchem-371	261	22	experimental	experimental	ADJ
eurjchem-371	261	23	values	value	NOUN
eurjchem-371	261	24	.	.	PUNCT
eurjchem-371	262	1	hence	hence	ADV
eurjchem-371	262	2	our	our	PRON
eurjchem-371	262	3	present	present	ADJ
eurjchem-371	262	4	work	work	NOUN
eurjchem-371	262	5	is	be	AUX
eurjchem-371	262	6	limited	limit	VERB
eurjchem-371	262	7	only	only	ADV
eurjchem-371	262	8	till	till	SCONJ
eurjchem-371	262	9	to	to	ADP
eurjchem-371	262	10	the	the	DET
eurjchem-371	262	11	comparison	comparison	NOUN
eurjchem-371	262	12	between	between	ADP
eurjchem-371	262	13	potentiometry	potentiometry	NOUN
eurjchem-371	262	14	and	and	CCONJ
eurjchem-371	262	15	hplc	hplc	NOUN
eurjchem-371	262	16	methods	method	NOUN
eurjchem-371	262	17	.	.	PUNCT
eurjchem-371	263	1	4	4	X
eurjchem-371	263	2	.	.	X
eurjchem-371	263	3	conclusion	conclusion	VERB
eurjchem-371	263	4	the	the	DET
eurjchem-371	263	5	application	application	NOUN
eurjchem-371	263	6	of	of	ADP
eurjchem-371	263	7	co	co	ADJ
eurjchem-371	263	8	solvent	solvent	PROPN
eurjchem-371	263	9	–	–	PUNCT
eurjchem-371	263	10	water	water	NOUN
eurjchem-371	263	11	mixtures	mixture	NOUN
eurjchem-371	263	12	improves	improve	VERB
eurjchem-371	263	13	the	the	DET
eurjchem-371	263	14	solubility	solubility	NOUN
eurjchem-371	263	15	of	of	ADP
eurjchem-371	263	16	poorly	poorly	ADV
eurjchem-371	263	17	water	water	NOUN
eurjchem-371	263	18	soluble	soluble	ADJ
eurjchem-371	263	19	drugs	drug	NOUN
eurjchem-371	263	20	thus	thus	ADV
eurjchem-371	263	21	their	their	PRON
eurjchem-371	263	22	pska	pska	NOUN
eurjchem-371	263	23	values	value	NOUN
eurjchem-371	263	24	can	can	AUX
eurjchem-371	263	25	be	be	AUX
eurjchem-371	263	26	measured	measure	VERB
eurjchem-371	263	27	in	in	ADP
eurjchem-371	263	28	lower	low	ADJ
eurjchem-371	263	29	proportion	proportion	NOUN
eurjchem-371	263	30	of	of	ADP
eurjchem-371	263	31	organic	organic	ADJ
eurjchem-371	263	32	solvent	solvent	NOUN
eurjchem-371	263	33	.	.	PUNCT
eurjchem-371	264	1	the	the	DET
eurjchem-371	264	2	co	co	X
eurjchem-371	264	3	solvent	solvent	PROPN
eurjchem-371	264	4	dissociation	dissociation	NOUN
eurjchem-371	264	5	constants	constant	NOUN
eurjchem-371	264	6	(	(	PUNCT
eurjchem-371	264	7	pska	pska	NOUN
eurjchem-371	264	8	)	)	PUNCT
eurjchem-371	264	9	of	of	ADP
eurjchem-371	264	10	selected	select	VERB
eurjchem-371	264	11	compounds	compound	NOUN
eurjchem-371	264	12	were	be	AUX
eurjchem-371	264	13	determined	determine	VERB
eurjchem-371	264	14	in	in	ADP
eurjchem-371	264	15	different	different	ADJ
eurjchem-371	264	16	co	co	NOUN
eurjchem-371	264	17	solvent	solvent	ADJ
eurjchem-371	264	18	–	–	PUNCT
eurjchem-371	264	19	water	water	NOUN
eurjchem-371	264	20	mixtures	mixture	NOUN
eurjchem-371	264	21	by	by	ADP
eurjchem-371	264	22	potentiometric	potentiometric	ADJ
eurjchem-371	264	23	and	and	CCONJ
eurjchem-371	264	24	spectrophotometric	spectrophotometric	ADJ
eurjchem-371	264	25	methods	method	NOUN
eurjchem-371	264	26	.	.	PUNCT
eurjchem-371	265	1	the	the	DET
eurjchem-371	265	2	co	co	X
eurjchem-371	265	3	solvent	solvent	PROPN
eurjchem-371	265	4	–	–	PUNCT
eurjchem-371	265	5	water	water	NOUN
eurjchem-371	265	6	mixtures	mixture	NOUN
eurjchem-371	265	7	did	do	AUX
eurjchem-371	265	8	not	not	PART
eurjchem-371	265	9	cause	cause	VERB
eurjchem-371	265	10	large	large	ADJ
eurjchem-371	265	11	shifts	shift	NOUN
eurjchem-371	265	12	in	in	ADP
eurjchem-371	265	13	pska	pska	NOUN
eurjchem-371	265	14	values	value	NOUN
eurjchem-371	265	15	and	and	CCONJ
eurjchem-371	265	16	the	the	DET
eurjchem-371	265	17	yasuda	yasuda	NOUN
eurjchem-371	265	18	–	–	PUNCT
eurjchem-371	265	19	shedlovsky	shedlovsky	ADJ
eurjchem-371	265	20	extrapolation	extrapolation	NOUN
eurjchem-371	265	21	procedure	procedure	NOUN
eurjchem-371	265	22	was	be	AUX
eurjchem-371	265	23	proposed	propose	VERB
eurjchem-371	265	24	to	to	PART
eurjchem-371	265	25	obtain	obtain	VERB
eurjchem-371	265	26	the	the	DET
eurjchem-371	265	27	aqueous	aqueous	ADJ
eurjchem-371	265	28	pka	pka	PROPN
eurjchem-371	265	29	values	value	NOUN
eurjchem-371	265	30	.	.	PUNCT
eurjchem-371	266	1	the	the	DET
eurjchem-371	266	2	extrapolated	extrapolated	ADJ
eurjchem-371	266	3	data	datum	NOUN
eurjchem-371	266	4	are	be	AUX
eurjchem-371	266	5	in	in	ADP
eurjchem-371	266	6	good	good	ADJ
eurjchem-371	266	7	agreement	agreement	NOUN
eurjchem-371	266	8	with	with	ADP
eurjchem-371	266	9	pka	pka	PROPN
eurjchem-371	266	10	values	value	NOUN
eurjchem-371	266	11	measured	measure	VERB
eurjchem-371	266	12	in	in	ADP
eurjchem-371	266	13	water	water	NOUN
eurjchem-371	266	14	.	.	PUNCT
eurjchem-371	267	1	the	the	DET
eurjchem-371	267	2	average	average	ADJ
eurjchem-371	267	3	deviation	deviation	NOUN
eurjchem-371	267	4	is	be	AUX
eurjchem-371	267	5	pka	pka	NOUN
eurjchem-371	267	6	=	=	NOUN
eurjchem-371	267	7	0.2	0.2	NUM
eurjchem-371	267	8	.	.	PUNCT
eurjchem-371	268	1	in	in	ADP
eurjchem-371	268	2	this	this	DET
eurjchem-371	268	3	way	way	NOUN
eurjchem-371	268	4	the	the	DET
eurjchem-371	268	5	proposed	propose	VERB
eurjchem-371	268	6	different	different	ADJ
eurjchem-371	268	7	co	co	NOUN
eurjchem-371	268	8	solvents	solvent	NOUN
eurjchem-371	268	9	can	can	AUX
eurjchem-371	268	10	be	be	AUX
eurjchem-371	268	11	applied	apply	VERB
eurjchem-371	268	12	to	to	ADP
eurjchem-371	268	13	those	those	DET
eurjchem-371	268	14	compounds	compound	NOUN
eurjchem-371	268	15	which	which	PRON
eurjchem-371	268	16	are	be	AUX
eurjchem-371	268	17	not	not	PART
eurjchem-371	268	18	soluble	soluble	ADJ
eurjchem-371	268	19	in	in	ADP
eurjchem-371	268	20	aqueous	aqueous	ADJ
eurjchem-371	268	21	solutions	solution	NOUN
eurjchem-371	268	22	and	and	CCONJ
eurjchem-371	268	23	can	can	AUX
eurjchem-371	268	24	be	be	AUX
eurjchem-371	268	25	easily	easily	ADV
eurjchem-371	268	26	adopted	adopt	VERB
eurjchem-371	268	27	in	in	ADP
eurjchem-371	268	28	drug	drug	NOUN
eurjchem-371	268	29	discovery	discovery	NOUN
eurjchem-371	268	30	laboratory	laboratory	NOUN
eurjchem-371	268	31	for	for	ADP
eurjchem-371	268	32	the	the	DET
eurjchem-371	268	33	determination	determination	NOUN
eurjchem-371	268	34	of	of	ADP
eurjchem-371	268	35	dissociation	dissociation	NOUN
eurjchem-371	268	36	constant	constant	ADJ
eurjchem-371	268	37	in	in	ADP
eurjchem-371	268	38	a	a	DET
eurjchem-371	268	39	high	high	ADJ
eurjchem-371	268	40	throughput	throughput	NOUN
eurjchem-371	268	41	manner	manner	NOUN
eurjchem-371	268	42	.	.	PUNCT
eurjchem-371	269	1	the	the	DET
eurjchem-371	269	2	knowledge	knowledge	NOUN
eurjchem-371	269	3	of	of	ADP
eurjchem-371	269	4	the	the	DET
eurjchem-371	269	5	acid	acid	ADJ
eurjchem-371	269	6	–	–	PUNCT
eurjchem-371	269	7	base	base	NOUN
eurjchem-371	269	8	behaviour	behaviour	NOUN
eurjchem-371	269	9	of	of	ADP
eurjchem-371	269	10	the	the	DET
eurjchem-371	269	11	drug	drug	NOUN
eurjchem-371	269	12	compounds	compound	NOUN
eurjchem-371	269	13	,	,	PUNCT
eurjchem-371	269	14	in	in	ADP
eurjchem-371	269	15	different	different	ADJ
eurjchem-371	269	16	hydro‐organic	hydro‐organic	ADJ
eurjchem-371	269	17	media	medium	NOUN
eurjchem-371	269	18	is	be	AUX
eurjchem-371	269	19	therefore	therefore	ADV
eurjchem-371	269	20	a	a	DET
eurjchem-371	269	21	useful	useful	ADJ
eurjchem-371	269	22	parameter	parameter	NOUN
eurjchem-371	269	23	to	to	PART
eurjchem-371	269	24	optimize	optimize	VERB
eurjchem-371	269	25	analytical	analytical	ADJ
eurjchem-371	269	26	procedures	procedure	NOUN
eurjchem-371	269	27	for	for	ADP
eurjchem-371	269	28	the	the	DET
eurjchem-371	269	29	separation	separation	NOUN
eurjchem-371	269	30	of	of	ADP
eurjchem-371	269	31	ionizable	ionizable	ADJ
eurjchem-371	269	32	compounds	compound	NOUN
eurjchem-371	269	33	by	by	ADP
eurjchem-371	269	34	liquid	liquid	ADJ
eurjchem-371	269	35	chromatography	chromatography	NOUN
eurjchem-371	269	36	,	,	PUNCT
eurjchem-371	269	37	especially	especially	ADV
eurjchem-371	269	38	when	when	SCONJ
eurjchem-371	269	39	these	these	DET
eurjchem-371	269	40	drugs	drug	NOUN
eurjchem-371	269	41	are	be	AUX
eurjchem-371	269	42	present	present	ADJ
eurjchem-371	269	43	in	in	ADP
eurjchem-371	269	44	combination	combination	NOUN
eurjchem-371	269	45	with	with	ADP
eurjchem-371	269	46	other	other	ADJ
eurjchem-371	269	47	drugs	drug	NOUN
eurjchem-371	269	48	.	.	PUNCT
eurjchem-371	270	1	acknowledgement	acknowledgement	NOUN
eurjchem-371	270	2	the	the	DET
eurjchem-371	270	3	authors	author	NOUN
eurjchem-371	270	4	wish	wish	VERB
eurjchem-371	270	5	to	to	PART
eurjchem-371	270	6	thank	thank	VERB
eurjchem-371	270	7	the	the	DET
eurjchem-371	270	8	management	management	NOUN
eurjchem-371	270	9	of	of	ADP
eurjchem-371	270	10	nycomed	nycome	VERB
eurjchem-371	270	11	pharma	pharma	PROPN
eurjchem-371	270	12	pvt	pvt	PROPN
eurjchem-371	270	13	ltd	ltd	PROPN
eurjchem-371	270	14	.	.	PROPN
eurjchem-371	271	1	(	(	PUNCT
eurjchem-371	271	2	mumbai	mumbai	PROPN
eurjchem-371	271	3	,	,	PUNCT
eurjchem-371	271	4	india	india	PROPN
eurjchem-371	271	5	)	)	PUNCT
eurjchem-371	271	6	for	for	ADP
eurjchem-371	271	7	providing	provide	VERB
eurjchem-371	271	8	necessary	necessary	ADJ
eurjchem-371	271	9	facilities	facility	NOUN
eurjchem-371	271	10	and	and	CCONJ
eurjchem-371	271	11	technical	technical	ADJ
eurjchem-371	271	12	support	support	NOUN
eurjchem-371	271	13	.	.	PUNCT
eurjchem-371	272	1	references	reference	NOUN
eurjchem-371	272	2	[	[	X
eurjchem-371	272	3	1	1	NUM
eurjchem-371	272	4	]	]	PUNCT
eurjchem-371	272	5	.	.	PUNCT
eurjchem-371	273	1	albert	albert	PROPN
eurjchem-371	273	2	,	,	PUNCT
eurjchem-371	273	3	a.	a.	NOUN
eurjchem-371	273	4	and	and	CCONJ
eurjchem-371	273	5	serjeant	serjeant	NOUN
eurjchem-371	273	6	,	,	PUNCT
eurjchem-371	273	7	e.	e.	PROPN
eurjchem-371	273	8	p.	p.	PROPN
eurjchem-371	274	1	a	a	DET
eurjchem-371	274	2	laboratory	laboratory	NOUN
eurjchem-371	274	3	manual	manual	NOUN
eurjchem-371	274	4	,	,	PUNCT
eurjchem-371	274	5	3rd	3rd	ADJ
eurjchem-371	274	6	edition	edition	NOUN
eurjchem-371	274	7	,	,	PUNCT
eurjchem-371	274	8	chapman	chapman	NOUN
eurjchem-371	274	9	and	and	CCONJ
eurjchem-371	274	10	hall	hall	PROPN
eurjchem-371	274	11	london	london	PROPN
eurjchem-371	274	12	.	.	PUNCT
eurjchem-371	274	13	1984	1984	NUM
eurjchem-371	274	14	.	.	PUNCT
eurjchem-371	275	1	[	[	X
eurjchem-371	275	2	2	2	NUM
eurjchem-371	275	3	]	]	PUNCT
eurjchem-371	275	4	.	.	PUNCT
eurjchem-371	276	1	ramette	ramette	PROPN
eurjchem-371	276	2	r.	r.	PROPN
eurjchem-371	276	3	w.	w.	PROPN
eurjchem-371	276	4	j.	j.	PROPN
eurjchem-371	276	5	chem	chem	PROPN
eurjchem-371	276	6	.	.	PUNCT
eurjchem-371	277	1	educ	educ	PROPN
eurjchem-371	277	2	.	.	PUNCT
eurjchem-371	278	1	1967	1967	NUM
eurjchem-371	278	2	,	,	PUNCT
eurjchem-371	278	3	44	44	NUM
eurjchem-371	278	4	,	,	PUNCT
eurjchem-371	278	5	647‐654	647‐654	NUM
eurjchem-371	278	6	.	.	PUNCT
eurjchem-371	279	1	[	[	X
eurjchem-371	279	2	3	3	NUM
eurjchem-371	279	3	]	]	PUNCT
eurjchem-371	279	4	.	.	PUNCT
eurjchem-371	280	1	serjeant	serjeant	PROPN
eurjchem-371	280	2	e.	e.	PROPN
eurjchem-371	280	3	p.	p.	PROPN
eurjchem-371	280	4	john	john	PROPN
eurjchem-371	280	5	&	&	CCONJ
eurjchem-371	280	6	wiley	wiley	PROPN
eurjchem-371	280	7	and	and	CCONJ
eurjchem-371	280	8	sons	son	NOUN
eurjchem-371	280	9	,	,	PUNCT
eurjchem-371	280	10	new	new	PROPN
eurjchem-371	280	11	york	york	PROPN
eurjchem-371	280	12	,	,	PUNCT
eurjchem-371	280	13	1984	1984	NUM
eurjchem-371	280	14	.	.	PUNCT
eurjchem-371	281	1	[	[	X
eurjchem-371	281	2	4	4	NUM
eurjchem-371	281	3	]	]	PUNCT
eurjchem-371	281	4	.	.	PUNCT
eurjchem-371	282	1	qiang	qiang	PROPN
eurjchem-371	282	2	,	,	PUNCT
eurjchem-371	282	3	z.	z.	PROPN
eurjchem-371	282	4	;	;	PUNCT
eurjchem-371	282	5	adams	adams	PROPN
eurjchem-371	282	6	,	,	PUNCT
eurjchem-371	282	7	c.	c.	PROPN
eurjchem-371	282	8	water	water	NOUN
eurjchem-371	282	9	res	re	NOUN
eurjchem-371	282	10	.	.	PUNCT
eurjchem-371	282	11	2004	2004	NUM
eurjchem-371	282	12	,	,	PUNCT
eurjchem-371	282	13	38	38	NUM
eurjchem-371	282	14	,	,	PUNCT
eurjchem-371	282	15	2874‐2890	2874‐2890	ADJ
eurjchem-371	282	16	.	.	PUNCT
eurjchem-371	283	1	[	[	X
eurjchem-371	283	2	5	5	NUM
eurjchem-371	283	3	]	]	PUNCT
eurjchem-371	283	4	.	.	PUNCT
eurjchem-371	284	1	pool	pool	NOUN
eurjchem-371	284	2	,	,	PUNCT
eurjchem-371	284	3	s.	s.	PROPN
eurjchem-371	284	4	k.	k.	PROPN
eurjchem-371	284	5	;	;	PUNCT
eurjchem-371	284	6	patel	patel	PROPN
eurjchem-371	284	7	,	,	PUNCT
eurjchem-371	284	8	s.	s.	PROPN
eurjchem-371	284	9	;	;	PUNCT
eurjchem-371	284	10	dehring	dehre	VERB
eurjchem-371	284	11	,	,	PUNCT
eurjchem-371	284	12	k.	k.	PROPN
eurjchem-371	284	13	;	;	PUNCT
eurjchem-371	284	14	workman	workman	PROPN
eurjchem-371	284	15	,	,	PUNCT
eurjchem-371	284	16	h.	h.	PROPN
eurjchem-371	284	17	;	;	PUNCT
eurjchem-371	284	18	pool	pool	NOUN
eurjchem-371	284	19	,	,	PUNCT
eurjchem-371	284	20	c.	c.	PROPN
eurjchem-371	284	21	f.	f.	PROPN
eurjchem-371	284	22	j.	j.	PROPN
eurjchem-371	284	23	chromatogr	chromatogr	PROPN
eurjchem-371	284	24	.	.	PUNCT
eurjchem-371	285	1	a	a	DET
eurjchem-371	285	2	2004	2004	NUM
eurjchem-371	285	3	,	,	PUNCT
eurjchem-371	285	4	1037	1037	NUM
eurjchem-371	285	5	,	,	PUNCT
eurjchem-371	285	6	445‐454	445‐454	NOUN
eurjchem-371	285	7	.	.	PUNCT
eurjchem-371	286	1	[	[	X
eurjchem-371	286	2	6	6	NUM
eurjchem-371	286	3	]	]	PUNCT
eurjchem-371	286	4	.	.	PUNCT
eurjchem-371	286	5	erdemgil	erdemgil	PROPN
eurjchem-371	286	6	,	,	PUNCT
eurjchem-371	286	7	f.	f.	PROPN
eurjchem-371	286	8	z.	z.	PROPN
eurjchem-371	286	9	;	;	PUNCT
eurjchem-371	286	10	sanli	sanli	PROPN
eurjchem-371	286	11	,	,	PUNCT
eurjchem-371	286	12	s.	s.	PROPN
eurjchem-371	286	13	;	;	PUNCT
eurjchem-371	286	14	sanli	sanli	NOUN
eurjchem-371	286	15	,	,	PUNCT
eurjchem-371	286	16	n.	n.	NOUN
eurjchem-371	286	17	;	;	PUNCT
eurjchem-371	286	18	ozkan	ozkan	PROPN
eurjchem-371	286	19	,	,	PUNCT
eurjchem-371	286	20	g.	g.	PROPN
eurjchem-371	286	21	;	;	PUNCT
eurjchem-371	286	22	barbosa	barbosa	PROPN
eurjchem-371	286	23	,	,	PUNCT
eurjchem-371	286	24	j.	j.	PROPN
eurjchem-371	286	25	;	;	PUNCT
eurjchem-371	286	26	guiteras	guiteras	PROPN
eurjchem-371	286	27	,	,	PUNCT
eurjchem-371	286	28	j.	j.	PROPN
eurjchem-371	286	29	;	;	PUNCT
eurjchem-371	286	30	beltran	beltran	PROPN
eurjchem-371	286	31	,	,	PUNCT
eurjchem-371	286	32	j.	j.	PROPN
eurjchem-371	286	33	l.	l.	PROPN
eurjchem-371	286	34	talanta	talanta	PROPN
eurjchem-371	286	35	2007	2007	NUM
eurjchem-371	286	36	,	,	PUNCT
eurjchem-371	286	37	72	72	NUM
eurjchem-371	286	38	,	,	PUNCT
eurjchem-371	286	39	489‐496	489‐496	NOUN
eurjchem-371	286	40	.	.	PUNCT
eurjchem-371	287	1	46	46	NUM
eurjchem-371	287	2	narasimham	narasimham	PROPN
eurjchem-371	287	3	and	and	CCONJ
eurjchem-371	287	4	barhate	barhate	VERB
eurjchem-371	287	5	/	/	SYM
eurjchem-371	287	6	european	european	ADJ
eurjchem-371	287	7	journal	journal	PROPN
eurjchem-371	287	8	of	of	ADP
eurjchem-371	287	9	chemistry	chemistry	NOUN
eurjchem-371	287	10	2	2	NUM
eurjchem-371	287	11	(	(	PUNCT
eurjchem-371	287	12	1	1	NUM
eurjchem-371	287	13	)	)	PUNCT
eurjchem-371	287	14	(	(	PUNCT
eurjchem-371	287	15	2011	2011	NUM
eurjchem-371	287	16	)	)	PUNCT
eurjchem-371	287	17	36‐46	36‐46	NUM
eurjchem-371	288	1	[	[	X
eurjchem-371	288	2	7	7	NUM
eurjchem-371	288	3	]	]	PUNCT
eurjchem-371	288	4	.	.	PUNCT
eurjchem-371	289	1	evagelou	evagelou	ADJ
eurjchem-371	289	2	,	,	PUNCT
eurjchem-371	289	3	v.	v.	ADV
eurjchem-371	289	4	;	;	PUNCT
eurjchem-371	289	5	tsantili‐kakoulidou	tsantili‐kakoulidou	X
eurjchem-371	289	6	,	,	PUNCT
eurjchem-371	289	7	a.	a.	NOUN
eurjchem-371	289	8	;	;	PUNCT
eurjchem-371	289	9	koupparis	koupparis	PROPN
eurjchem-371	289	10	,	,	PUNCT
eurjchem-371	289	11	m.	m.	PROPN
eurjchem-371	289	12	j.	j.	PROPN
eurjchem-371	289	13	pharm	pharm	PROPN
eurjchem-371	289	14	.	.	PUNCT
eurjchem-371	289	15	biomed	biome	VERB
eurjchem-371	289	16	.	.	PUNCT
eurjchem-371	290	1	anal	anal	PROPN
eurjchem-371	290	2	.	.	PUNCT
eurjchem-371	291	1	2003	2003	NUM
eurjchem-371	291	2	,	,	PUNCT
eurjchem-371	291	3	31	31	NUM
eurjchem-371	291	4	,	,	PUNCT
eurjchem-371	291	5	1119‐1128	1119‐1128	NUM
eurjchem-371	291	6	.	.	PUNCT
eurjchem-371	292	1	[	[	X
eurjchem-371	292	2	8	8	NUM
eurjchem-371	292	3	]	]	PUNCT
eurjchem-371	292	4	.	.	PUNCT
eurjchem-371	293	1	jimenez‐lozano	jimenez‐lozano	PROPN
eurjchem-371	293	2	,	,	PUNCT
eurjchem-371	293	3	e.	e.	PROPN
eurjchem-371	293	4	;	;	PUNCT
eurjchem-371	293	5	marques	marques	PROPN
eurjchem-371	293	6	,	,	PUNCT
eurjchem-371	293	7	i.	i.	PROPN
eurjchem-371	293	8	;	;	PUNCT
eurjchem-371	293	9	barron	barron	PROPN
eurjchem-371	293	10	,	,	PUNCT
eurjchem-371	293	11	d.	d.	PROPN
eurjchem-371	293	12	;	;	PUNCT
eurjchem-371	293	13	beltran	beltran	PROPN
eurjchem-371	293	14	,	,	PUNCT
eurjchem-371	293	15	j.	j.	PROPN
eurjchem-371	293	16	l.	l.	PROPN
eurjchem-371	293	17	;	;	PUNCT
eurjchem-371	293	18	barbosa	barbosa	PROPN
eurjchem-371	293	19	,	,	PUNCT
eurjchem-371	293	20	j.	j.	PROPN
eurjchem-371	293	21	anal	anal	PROPN
eurjchem-371	293	22	.	.	PUNCT
eurjchem-371	294	1	chim	chim	PROPN
eurjchem-371	294	2	.	.	PUNCT
eurjchem-371	295	1	acta	acta	PROPN
eurjchem-371	295	2	2002	2002	NUM
eurjchem-371	295	3	,	,	PUNCT
eurjchem-371	295	4	464	464	NUM
eurjchem-371	295	5	,	,	PUNCT
eurjchem-371	295	6	37‐45	37‐45	NUM
eurjchem-371	295	7	.	.	PUNCT
eurjchem-371	296	1	[	[	X
eurjchem-371	296	2	9	9	NUM
eurjchem-371	296	3	]	]	PUNCT
eurjchem-371	296	4	.	.	PUNCT
eurjchem-371	297	1	janos	janos	PROPN
eurjchem-371	297	2	p.	p.	PROPN
eurjchem-371	297	3	j.	j.	PROPN
eurjchem-371	297	4	chromatogr	chromatogr	PROPN
eurjchem-371	297	5	.	.	PUNCT
eurjchem-371	298	1	a	a	DET
eurjchem-371	298	2	2004	2004	NUM
eurjchem-371	298	3	,	,	PUNCT
eurjchem-371	298	4	1037	1037	NUM
eurjchem-371	298	5	,	,	PUNCT
eurjchem-371	298	6	15‐28	15‐28	NUM
eurjchem-371	298	7	.	.	PUNCT
eurjchem-371	299	1	[	[	X
eurjchem-371	299	2	10	10	NUM
eurjchem-371	299	3	]	]	PUNCT
eurjchem-371	299	4	.	.	PUNCT
eurjchem-371	299	5	andrasi	andrasi	PROPN
eurjchem-371	299	6	,	,	PUNCT
eurjchem-371	299	7	m.	m.	NOUN
eurjchem-371	299	8	;	;	PUNCT
eurjchem-371	299	9	buglyo	buglyo	NOUN
eurjchem-371	299	10	,	,	PUNCT
eurjchem-371	299	11	p.	p.	NOUN
eurjchem-371	299	12	;	;	PUNCT
eurjchem-371	299	13	zekany	zekany	NUM
eurjchem-371	299	14	,	,	PUNCT
eurjchem-371	299	15	l.	l.	PROPN
eurjchem-371	299	16	;	;	PUNCT
eurjchem-371	299	17	gaspar	gaspar	PROPN
eurjchem-371	299	18	,	,	PUNCT
eurjchem-371	299	19	a.	a.	PROPN
eurjchem-371	299	20	j.	j.	PROPN
eurjchem-371	299	21	pharm	pharm	PROPN
eurjchem-371	299	22	.	.	PUNCT
eurjchem-371	299	23	biomed	biome	VERB
eurjchem-371	299	24	.	.	PUNCT
eurjchem-371	300	1	anal	anal	PROPN
eurjchem-371	300	2	.	.	PUNCT
eurjchem-371	301	1	2007	2007	NUM
eurjchem-371	301	2	,	,	PUNCT
eurjchem-371	301	3	44	44	NUM
eurjchem-371	301	4	,	,	PUNCT
eurjchem-371	301	5	1040‐1047	1040‐1047	NUM
eurjchem-371	301	6	.	.	PUNCT
eurjchem-371	302	1	[	[	X
eurjchem-371	302	2	11	11	NUM
eurjchem-371	302	3	]	]	PUNCT
eurjchem-371	302	4	.	.	PUNCT
eurjchem-371	303	1	wrobel	wrobel	PROPN
eurjchem-371	303	2	,	,	PUNCT
eurjchem-371	303	3	r.	r.	PROPN
eurjchem-371	303	4	;	;	PUNCT
eurjchem-371	303	5	chmurzynski	chmurzynski	ADJ
eurjchem-371	303	6	,	,	PUNCT
eurjchem-371	303	7	l.	l.	PROPN
eurjchem-371	303	8	anal	anal	PROPN
eurjchem-371	303	9	.	.	PUNCT
eurjchem-371	304	1	chim	chim	PROPN
eurjchem-371	304	2	.	.	PUNCT
eurjchem-371	305	1	acta	acta	PROPN
eurjchem-371	305	2	2000	2000	NUM
eurjchem-371	305	3	,	,	PUNCT
eurjchem-371	305	4	405	405	NUM
eurjchem-371	305	5	,	,	PUNCT
eurjchem-371	305	6	303‐308	303‐308	NUM
eurjchem-371	305	7	.	.	PUNCT
eurjchem-371	306	1	[	[	X
eurjchem-371	306	2	12	12	NUM
eurjchem-371	306	3	]	]	PUNCT
eurjchem-371	306	4	.	.	PUNCT
eurjchem-371	307	1	meloun	meloun	ADJ
eurjchem-371	307	2	,	,	PUNCT
eurjchem-371	307	3	m.	m.	NOUN
eurjchem-371	307	4	;	;	PUNCT
eurjchem-371	307	5	havel	havel	PROPN
eurjchem-371	307	6	,	,	PUNCT
eurjchem-371	307	7	j.	j.	PROPN
eurjchem-371	307	8	;	;	PUNCT
eurjchem-371	307	9	högfeldt	högfeldt	PROPN
eurjchem-371	307	10	,	,	PUNCT
eurjchem-371	307	11	e.	e.	PROPN
eurjchem-371	307	12	computation	computation	PROPN
eurjchem-371	307	13	of	of	ADP
eurjchem-371	307	14	solution	solution	NOUN
eurjchem-371	307	15	equilibria	equilibrium	NOUN
eurjchem-371	307	16	,	,	PUNCT
eurjchem-371	307	17	ellis	ellis	PROPN
eurjchem-371	307	18	horwood	horwood	PROPN
eurjchem-371	307	19	,	,	PUNCT
eurjchem-371	307	20	chichester	chichester	PROPN
eurjchem-371	307	21	,	,	PUNCT
eurjchem-371	307	22	1988	1988	NUM
eurjchem-371	307	23	.	.	PUNCT
eurjchem-371	308	1	[	[	X
eurjchem-371	308	2	13	13	NUM
eurjchem-371	308	3	]	]	PUNCT
eurjchem-371	308	4	.	.	PUNCT
eurjchem-371	309	1	ying‐sing	ying‐sing	PROPN
eurjchem-371	309	2	,	,	PUNCT
eurjchem-371	309	3	f.	f.	PROPN
eurjchem-371	309	4	;	;	PUNCT
eurjchem-371	309	5	shiu‐fai	shiu‐fai	NOUN
eurjchem-371	309	6	,	,	PUNCT
eurjchem-371	309	7	l.	l.	PROPN
eurjchem-371	309	8	analyst	analyst	PROPN
eurjchem-371	309	9	1985	1985	NUM
eurjchem-371	309	10	,	,	PUNCT
eurjchem-371	309	11	110	110	NUM
eurjchem-371	309	12	,	,	PUNCT
eurjchem-371	309	13	1439‐1444	1439‐1444	NUM
eurjchem-371	309	14	.	.	PUNCT
eurjchem-371	310	1	[	[	X
eurjchem-371	310	2	14	14	NUM
eurjchem-371	310	3	]	]	PUNCT
eurjchem-371	310	4	.	.	PUNCT
eurjchem-371	310	5	papanastasiou	papanastasiou	NOUN
eurjchem-371	310	6	,	,	PUNCT
eurjchem-371	310	7	g.	g.	PROPN
eurjchem-371	310	8	;	;	PUNCT
eurjchem-371	310	9	ziogas	ziogas	NOUN
eurjchem-371	310	10	,	,	PUNCT
eurjchem-371	310	11	i.	i.	PROPN
eurjchem-371	310	12	talanta	talanta	PROPN
eurjchem-371	310	13	1989	1989	NUM
eurjchem-371	310	14	,	,	PUNCT
eurjchem-371	310	15	36	36	NUM
eurjchem-371	310	16	,	,	PUNCT
eurjchem-371	310	17	977‐983	977‐983	NUM
eurjchem-371	310	18	.	.	PUNCT
eurjchem-371	311	1	[	[	X
eurjchem-371	311	2	15	15	NUM
eurjchem-371	311	3	]	]	PUNCT
eurjchem-371	311	4	.	.	PUNCT
eurjchem-371	311	5	guillén	guillén	PROPN
eurjchem-371	311	6	,	,	PUNCT
eurjchem-371	311	7	s.	s.	PROPN
eurjchem-371	311	8	r.	r.	PROPN
eurjchem-371	311	9	;	;	PUNCT
eurjchem-371	311	10	guzmán	guzmán	PROPN
eurjchem-371	311	11	,	,	PUNCT
eurjchem-371	311	12	c.	c.	PROPN
eurjchem-371	311	13	m.	m.	PROPN
eurjchem-371	311	14	microchem	microchem	PROPN
eurjchem-371	311	15	.	.	PUNCT
eurjchem-371	312	1	j.	j.	PROPN
eurjchem-371	312	2	1988	1988	NUM
eurjchem-371	312	3	,	,	PUNCT
eurjchem-371	312	4	37	37	NUM
eurjchem-371	312	5	,	,	PUNCT
eurjchem-371	312	6	40‐50	40‐50	NUM
eurjchem-371	312	7	.	.	PUNCT
eurjchem-371	313	1	[	[	X
eurjchem-371	313	2	16	16	NUM
eurjchem-371	313	3	]	]	PUNCT
eurjchem-371	313	4	.	.	PUNCT
eurjchem-371	314	1	avdeef	avdeef	PROPN
eurjchem-371	314	2	,	,	PUNCT
eurjchem-371	314	3	a.	a.	PROPN
eurjchem-371	314	4	anal	anal	PROPN
eurjchem-371	314	5	.	.	PUNCT
eurjchem-371	315	1	chim	chim	PROPN
eurjchem-371	315	2	.	.	PUNCT
eurjchem-371	316	1	acta	acta	PROPN
eurjchem-371	316	2	1983	1983	NUM
eurjchem-371	316	3	,	,	PUNCT
eurjchem-371	316	4	148	148	NUM
eurjchem-371	316	5	,	,	PUNCT
eurjchem-371	316	6	237‐244	237‐244	NUM
eurjchem-371	316	7	.	.	PUNCT
eurjchem-371	317	1	[	[	X
eurjchem-371	317	2	17	17	NUM
eurjchem-371	317	3	]	]	PUNCT
eurjchem-371	317	4	.	.	PUNCT
eurjchem-371	318	1	kin	kin	PROPN
eurjchem-371	318	2	,	,	PUNCT
eurjchem-371	318	3	t.	t.	PROPN
eurjchem-371	318	4	y.	y.	PROPN
eurjchem-371	318	5	;	;	PUNCT
eurjchem-371	318	6	krisztina	krisztina	PROPN
eurjchem-371	318	7	,	,	PUNCT
eurjchem-371	318	8	t.	t.	PROPN
eurjchem-371	318	9	n.	n.	PROPN
eurjchem-371	318	10	anal	anal	PROPN
eurjchem-371	318	11	.	.	PUNCT
eurjchem-371	319	1	chim	chim	PROPN
eurjchem-371	319	2	.	.	PUNCT
eurjchem-371	320	1	acta	acta	PROPN
eurjchem-371	320	2	2001	2001	NUM
eurjchem-371	320	3	,	,	PUNCT
eurjchem-371	320	4	434	434	NUM
eurjchem-371	320	5	,	,	PUNCT
eurjchem-371	320	6	157‐167	157‐167	NUM
eurjchem-371	320	7	.	.	PUNCT
eurjchem-371	321	1	[	[	X
eurjchem-371	321	2	18	18	NUM
eurjchem-371	321	3	]	]	PUNCT
eurjchem-371	321	4	.	.	PUNCT
eurjchem-371	322	1	karl	karl	PROPN
eurjchem-371	322	2	,	,	PUNCT
eurjchem-371	322	3	b.	b.	PROPN
eurjchem-371	322	4	;	;	PUNCT
eurjchem-371	322	5	christopher	christopher	PROPN
eurjchem-371	322	6	,	,	PUNCT
eurjchem-371	322	7	b.	b.	PROPN
eurjchem-371	322	8	;	;	PUNCT
eurjchem-371	322	9	john	john	PROPN
eurjchem-371	322	10	,	,	PUNCT
eurjchem-371	322	11	c.	c.	PROPN
eurjchem-371	322	12	;	;	PUNCT
eurjchem-371	322	13	alan	alan	PROPN
eurjchem-371	322	14	,	,	PUNCT
eurjchem-371	322	15	h.	h.	PROPN
eurjchem-371	322	16	;	;	PUNCT
eurjchem-371	322	17	ruth	ruth	PROPN
eurjchem-371	322	18	,	,	PUNCT
eurjchem-371	322	19	a.	a.	NOUN
eurjchem-371	322	20	;	;	PUNCT
eurjchem-371	322	21	derek	derek	PROPN
eurjchem-371	322	22	,	,	PUNCT
eurjchem-371	322	23	r.	r.	PROPN
eurjchem-371	322	24	anal	anal	PROPN
eurjchem-371	322	25	.	.	PUNCT
eurjchem-371	323	1	chem	chem	PROPN
eurjchem-371	323	2	.	.	PUNCT
eurjchem-371	324	1	2003	2003	NUM
eurjchem-371	324	2	,	,	PUNCT
eurjchem-371	324	3	75	75	NUM
eurjchem-371	324	4	,	,	PUNCT
eurjchem-371	324	5	883‐892	883‐892	PROPN
eurjchem-371	324	6	.	.	PUNCT
eurjchem-371	325	1	[	[	X
eurjchem-371	325	2	19	19	NUM
eurjchem-371	325	3	]	]	PUNCT
eurjchem-371	325	4	.	.	PUNCT
eurjchem-371	326	1	avdeef	avdeef	PROPN
eurjchem-371	326	2	,	,	PUNCT
eurjchem-371	326	3	a.	a.	PROPN
eurjchem-371	326	4	;	;	PUNCT
eurjchem-371	326	5	john	john	PROPN
eurjchem-371	326	6	,	,	PUNCT
eurjchem-371	326	7	e.	e.	PROPN
eurjchem-371	326	8	a.	a.	PROPN
eurjchem-371	326	9	c.	c.	PROPN
eurjchem-371	326	10	;	;	PUNCT
eurjchem-371	326	11	simon	simon	PROPN
eurjchem-371	326	12	,	,	PUNCT
eurjchem-371	326	13	j.	j.	PROPN
eurjchem-371	326	14	t.	t.	PROPN
eurjchem-371	326	15	anal	anal	PROPN
eurjchem-371	326	16	.	.	PUNCT
eurjchem-371	326	17	chem	chem	PROPN
eurjchem-371	326	18	.	.	PUNCT
eurjchem-371	327	1	1993	1993	NUM
eurjchem-371	327	2	,	,	PUNCT
eurjchem-371	327	3	65	65	NUM
eurjchem-371	327	4	,	,	PUNCT
eurjchem-371	327	5	42‐49	42‐49	NUM
eurjchem-371	327	6	.	.	PUNCT
eurjchem-371	328	1	[	[	X
eurjchem-371	328	2	20	20	NUM
eurjchem-371	328	3	]	]	PUNCT
eurjchem-371	328	4	.	.	PUNCT
eurjchem-371	329	1	krisztina	krisztina	PROPN
eurjchem-371	329	2	,	,	PUNCT
eurjchem-371	329	3	t.	t.	PROPN
eurjchem-371	329	4	n.	n.	PROPN
eurjchem-371	329	5	;	;	PUNCT
eurjchem-371	329	6	karl	karl	PROPN
eurjchem-371	329	7	,	,	PUNCT
eurjchem-371	329	8	b.	b.	PROPN
eurjchem-371	329	9	;	;	PUNCT
eurjchem-371	329	10	avdeef	avdeef	PROPN
eurjchem-371	329	11	,	,	PUNCT
eurjchem-371	329	12	a.	a.	NOUN
eurjchem-371	329	13	int	int	PROPN
eurjchem-371	329	14	.	.	PUNCT
eurjchem-371	330	1	j.	j.	PROPN
eurjchem-371	330	2	pharm	pharm	PROPN
eurjchem-371	330	3	.	.	PUNCT
eurjchem-371	331	1	1997	1997	NUM
eurjchem-371	331	2	,	,	PUNCT
eurjchem-371	331	3	151	151	NUM
eurjchem-371	331	4	,	,	PUNCT
eurjchem-371	331	5	235‐248	235‐248	NUM
eurjchem-371	331	6	.	.	PUNCT
eurjchem-371	332	1	[	[	X
eurjchem-371	332	2	21	21	NUM
eurjchem-371	332	3	]	]	PUNCT
eurjchem-371	332	4	.	.	PUNCT
eurjchem-371	332	5	avdeef	avdeef	PROPN
eurjchem-371	332	6	,	,	PUNCT
eurjchem-371	332	7	a.	a.	PROPN
eurjchem-371	332	8	;	;	PUNCT
eurjchem-371	332	9	karl	karl	PROPN
eurjchem-371	332	10	,	,	PUNCT
eurjchem-371	332	11	j.	j.	PROPN
eurjchem-371	332	12	b.	b.	PROPN
eurjchem-371	332	13	;	;	PUNCT
eurjchem-371	332	14	john	john	PROPN
eurjchem-371	332	15	,	,	PUNCT
eurjchem-371	332	16	e.	e.	PROPN
eurjchem-371	332	17	a.	a.	PROPN
eurjchem-371	332	18	c.	c.	PROPN
eurjchem-371	332	19	;	;	PUNCT
eurjchem-371	332	20	gilges	gilge	NOUN
eurjchem-371	332	21	,	,	PUNCT
eurjchem-371	332	22	m.	m.	NOUN
eurjchem-371	332	23	;	;	PUNCT
eurjchem-371	332	24	hadley	hadley	PROPN
eurjchem-371	332	25	,	,	PUNCT
eurjchem-371	332	26	m.	m.	NOUN
eurjchem-371	332	27	;	;	PUNCT
eurjchem-371	332	28	hibbert	hibbert	PROPN
eurjchem-371	332	29	,	,	PUNCT
eurjchem-371	332	30	c.	c.	PROPN
eurjchem-371	332	31	;	;	PUNCT
eurjchem-371	332	32	patterson	patterson	PROPN
eurjchem-371	332	33	,	,	PUNCT
eurjchem-371	332	34	w.	w.	PROPN
eurjchem-371	332	35	;	;	PUNCT
eurjchem-371	332	36	tam	tam	PROPN
eurjchem-371	332	37	,	,	PUNCT
eurjchem-371	332	38	k.	k.	PROPN
eurjchem-371	332	39	y.	y.	PROPN
eurjchem-371	332	40	j.	j.	PROPN
eurjchem-371	332	41	pharm	pharm	PROPN
eurjchem-371	332	42	.	.	PUNCT
eurjchem-371	332	43	biomed	biome	VERB
eurjchem-371	332	44	.	.	PUNCT
eurjchem-371	333	1	anal	anal	PROPN
eurjchem-371	333	2	.	.	PUNCT
eurjchem-371	334	1	1999	1999	NUM
eurjchem-371	334	2	,	,	PUNCT
eurjchem-371	334	3	20	20	NUM
eurjchem-371	334	4	,	,	PUNCT
eurjchem-371	334	5	631‐641	631‐641	NUM
eurjchem-371	334	6	.	.	PUNCT
eurjchem-371	335	1	[	[	X
eurjchem-371	335	2	22	22	NUM
eurjchem-371	335	3	]	]	PUNCT
eurjchem-371	335	4	.	.	PUNCT
eurjchem-371	336	1	gergely	gergely	ADV
eurjchem-371	336	2	,	,	PUNCT
eurjchem-371	336	3	v.	v.	PROPN
eurjchem-371	336	4	;	;	PUNCT
eurjchem-371	336	5	rebeca	rebeca	PROPN
eurjchem-371	336	6	,	,	PUNCT
eurjchem-371	336	7	r.	r.	PROPN
eurjchem-371	336	8	;	;	PUNCT
eurjchem-371	336	9	karl	karl	PROPN
eurjchem-371	336	10	,	,	PUNCT
eurjchem-371	336	11	b.	b.	PROPN
eurjchem-371	336	12	;	;	PUNCT
eurjchem-371	336	13	john	john	PROPN
eurjchem-371	336	14	,	,	PUNCT
eurjchem-371	336	15	c.	c.	PROPN
eurjchem-371	336	16	;	;	PUNCT
eurjchem-371	336	17	elisabeth	elisabeth	PROPN
eurjchem-371	336	18	,	,	PUNCT
eurjchem-371	336	19	b.	b.	PROPN
eurjchem-371	336	20	;	;	PUNCT
eurjchem-371	336	21	krisztina	krisztina	PROPN
eurjchem-371	336	22	,	,	PUNCT
eurjchem-371	336	23	t.	t.	PROPN
eurjchem-371	336	24	n.	n.	PROPN
eurjchem-371	336	25	anal	anal	PROPN
eurjchem-371	336	26	.	.	PUNCT
eurjchem-371	337	1	chim	chim	PROPN
eurjchem-371	337	2	.	.	PUNCT
eurjchem-371	338	1	acta	acta	PROPN
eurjchem-371	338	2	2007	2007	NUM
eurjchem-371	338	3	,	,	PUNCT
eurjchem-371	338	4	583	583	NUM
eurjchem-371	338	5	,	,	PUNCT
eurjchem-371	338	6	418–428	418–428	NUM
eurjchem-371	338	7	.	.	PUNCT
eurjchem-371	339	1	[	[	X
eurjchem-371	339	2	23	23	NUM
eurjchem-371	339	3	]	]	PUNCT
eurjchem-371	339	4	.	.	PUNCT
eurjchem-371	339	5	avdeef	avdeef	PROPN
eurjchem-371	339	6	a.	a.	PROPN
eurjchem-371	339	7	j.	j.	PROPN
eurjchem-371	339	8	pharm	pharm	PROPN
eurjchem-371	339	9	.	.	PUNCT
eurjchem-371	340	1	sci	sci	PROPN
eurjchem-371	340	2	.	.	PROPN
eurjchem-371	340	3	1993	1993	NUM
eurjchem-371	340	4	,	,	PUNCT
eurjchem-371	340	5	82	82	NUM
eurjchem-371	340	6	,	,	PUNCT
eurjchem-371	340	7	183‐190	183‐190	NUM
eurjchem-371	340	8	.	.	PUNCT
eurjchem-371	341	1	[	[	X
eurjchem-371	341	2	24	24	NUM
eurjchem-371	341	3	]	]	PUNCT
eurjchem-371	341	4	.	.	PUNCT
eurjchem-371	342	1	kraft	kraft	PROPN
eurjchem-371	342	2	,	,	PUNCT
eurjchem-371	342	3	a.	a.	PROPN
eurjchem-371	342	4	j.	j.	PROPN
eurjchem-371	342	5	chem	chem	PROPN
eurjchem-371	342	6	.	.	PUNCT
eurjchem-371	343	1	educ	educ	PROPN
eurjchem-371	343	2	.	.	PUNCT
eurjchem-371	344	1	2003	2003	NUM
eurjchem-371	344	2	,	,	PUNCT
eurjchem-371	344	3	80	80	NUM
eurjchem-371	344	4	,	,	PUNCT
eurjchem-371	344	5	554‐559	554‐559	NUM
eurjchem-371	344	6	.	.	PUNCT
eurjchem-371	345	1	[	[	X
eurjchem-371	345	2	25	25	NUM
eurjchem-371	345	3	]	]	PUNCT
eurjchem-371	345	4	.	.	PUNCT
eurjchem-371	346	1	avdeef	avdeef	PROPN
eurjchem-371	346	2	,	,	PUNCT
eurjchem-371	346	3	a.	a.	PROPN
eurjchem-371	346	4	;	;	PUNCT
eurjchem-371	346	5	kearney	kearney	PROPN
eurjchem-371	346	6	,	,	PUNCT
eurjchem-371	346	7	d.	d.	PROPN
eurjchem-371	346	8	l.	l.	PROPN
eurjchem-371	346	9	;	;	PUNCT
eurjchem-371	346	10	brown	brown	PROPN
eurjchem-371	346	11	,	,	PUNCT
eurjchem-371	346	12	j.	j.	PROPN
eurjchem-371	346	13	a.	a.	PROPN
eurjchem-371	346	14	;	;	PUNCT
eurjchem-371	346	15	chemotti	chemotti	PROPN
eurjchem-371	346	16	jr	jr	PROPN
eurjchem-371	346	17	.	.	PROPN
eurjchem-371	346	18	,	,	PUNCT
eurjchem-371	346	19	a.	a.	PROPN
eurjchem-371	346	20	r.	r.	PROPN
eurjchem-371	346	21	anal	anal	PROPN
eurjchem-371	346	22	.	.	PUNCT
eurjchem-371	347	1	chem	chem	PROPN
eurjchem-371	347	2	.	.	PUNCT
eurjchem-371	348	1	1982	1982	NUM
eurjchem-371	348	2	,	,	PUNCT
eurjchem-371	348	3	54	54	NUM
eurjchem-371	348	4	,	,	PUNCT
eurjchem-371	348	5	2322–2326	2322–2326	NUM
eurjchem-371	348	6	.	.	PUNCT
eurjchem-371	349	1	[	[	X
eurjchem-371	349	2	26	26	NUM
eurjchem-371	349	3	]	]	PUNCT
eurjchem-371	349	4	.	.	PUNCT
eurjchem-371	350	1	tam	tam	PROPN
eurjchem-371	350	2	,	,	PUNCT
eurjchem-371	350	3	k.	k.	PROPN
eurjchem-371	350	4	y.	y.	PROPN
eurjchem-371	350	5	;	;	PUNCT
eurjchem-371	350	6	krisztina	krisztina	PROPN
eurjchem-371	350	7	,	,	PUNCT
eurjchem-371	350	8	t.	t.	PROPN
eurjchem-371	350	9	n.	n.	PROPN
eurjchem-371	350	10	anal	anal	PROPN
eurjchem-371	350	11	.	.	PUNCT
eurjchem-371	351	1	chim	chim	PROPN
eurjchem-371	351	2	.	.	PUNCT
eurjchem-371	352	1	acta	acta	PROPN
eurjchem-371	352	2	2001	2001	NUM
eurjchem-371	352	3	,	,	PUNCT
eurjchem-371	352	4	434	434	NUM
eurjchem-371	352	5	,	,	PUNCT
eurjchem-371	352	6	157‐167	157‐167	NUM
eurjchem-371	352	7	.	.	PUNCT
eurjchem-371	353	1	[	[	X
eurjchem-371	353	2	27	27	NUM
eurjchem-371	353	3	]	]	PUNCT
eurjchem-371	353	4	.	.	PUNCT
eurjchem-371	354	1	ruth	ruth	PROPN
eurjchem-371	354	2	,	,	PUNCT
eurjchem-371	354	3	a.	a.	NOUN
eurjchem-371	354	4	;	;	PUNCT
eurjchem-371	354	5	karl	karl	PROPN
eurjchem-371	354	6	,	,	PUNCT
eurjchem-371	354	7	b.	b.	PROPN
eurjchem-371	354	8	;	;	PUNCT
eurjchem-371	354	9	john	john	PROPN
eurjchem-371	354	10	,	,	PUNCT
eurjchem-371	354	11	c.	c.	PROPN
eurjchem-371	354	12	;	;	PUNCT
eurjchem-371	354	13	peake	peake	PROPN
eurjchem-371	354	14	c.	c.	PROPN
eurjchem-371	354	15	;	;	PUNCT
eurjchem-371	354	16	tam	tam	PROPN
eurjchem-371	354	17	k.	k.	PROPN
eurjchem-371	354	18	y.	y.	PROPN
eurjchem-371	354	19	j.	j.	PROPN
eurjchem-371	354	20	pharm	pharm	PROPN
eurjchem-371	354	21	.	.	PUNCT
eurjchem-371	355	1	biomed	biome	VERB
eurjchem-371	355	2	.	.	PUNCT
eurjchem-371	356	1	anal	anal	ADJ
eurjchem-371	356	2	.	.	PUNCT
eurjchem-371	357	1	1998	1998	NUM
eurjchem-371	357	2	,	,	PUNCT
eurjchem-371	357	3	17	17	NUM
eurjchem-371	357	4	,	,	PUNCT
eurjchem-371	357	5	699–712	699–712	NUM
eurjchem-371	357	6	.	.	PUNCT
eurjchem-371	358	1	[	[	X
eurjchem-371	358	2	28	28	NUM
eurjchem-371	358	3	]	]	PUNCT
eurjchem-371	358	4	.	.	PUNCT
eurjchem-371	359	1	krisztina	krisztina	PROPN
eurjchem-371	359	2	,	,	PUNCT
eurjchem-371	359	3	t.	t.	PROPN
eurjchem-371	359	4	n.	n.	PROPN
eurjchem-371	359	5	;	;	PUNCT
eurjchem-371	359	6	avdeef	avdeef	PROPN
eurjchem-371	359	7	,	,	PUNCT
eurjchem-371	359	8	a.	a.	PROPN
eurjchem-371	359	9	j.	j.	PROPN
eurjchem-371	359	10	pharm	pharm	PROPN
eurjchem-371	359	11	.	.	PUNCT
eurjchem-371	359	12	biomed	biome	VERB
eurjchem-371	359	13	.	.	PUNCT
eurjchem-371	360	1	anal	anal	ADJ
eurjchem-371	360	2	.	.	PUNCT
eurjchem-371	361	1	1996	1996	NUM
eurjchem-371	361	2	,	,	PUNCT
eurjchem-371	361	3	14	14	NUM
eurjchem-371	361	4	,	,	PUNCT
eurjchem-371	361	5	1405	1405	NUM
eurjchem-371	361	6	–	–	PUNCT
eurjchem-371	361	7	1413	1413	NUM
eurjchem-371	361	8	.	.	PUNCT
eurjchem-371	362	1	[	[	X
eurjchem-371	362	2	29	29	NUM
eurjchem-371	362	3	]	]	PUNCT
eurjchem-371	362	4	.	.	PUNCT
eurjchem-371	363	1	krisztina	krisztina	PROPN
eurjchem-371	363	2	,	,	PUNCT
eurjchem-371	363	3	t.	t.	PROPN
eurjchem-371	363	4	n.	n.	PROPN
eurjchem-371	363	5	;	;	PUNCT
eurjchem-371	363	6	avdeef	avdeef	PROPN
eurjchem-371	363	7	,	,	PUNCT
eurjchem-371	363	8	a.	a.	PROPN
eurjchem-371	363	9	;	;	PUNCT
eurjchem-371	363	10	karl	karl	PROPN
eurjchem-371	363	11	,	,	PUNCT
eurjchem-371	363	12	b.	b.	PROPN
eurjchem-371	363	13	;	;	PUNCT
eurjchem-371	363	14	podanyi	podanyi	PROPN
eurjchem-371	363	15	,	,	PUNCT
eurjchem-371	363	16	b.	b.	PROPN
eurjchem-371	363	17	;	;	PUNCT
eurjchem-371	363	18	szasz	szasz	NOUN
eurjchem-371	363	19	,	,	PUNCT
eurjchem-371	363	20	g.	g.	PROPN
eurjchem-371	363	21	j.	j.	PROPN
eurjchem-371	363	22	pharm	pharm	PROPN
eurjchem-371	363	23	.	.	PUNCT
eurjchem-371	364	1	biomed	biome	VERB
eurjchem-371	364	2	.	.	PUNCT
eurjchem-371	365	1	anal	anal	PROPN
eurjchem-371	365	2	.	.	PUNCT
eurjchem-371	365	3	1994	1994	NUM
eurjchem-371	365	4	,	,	PUNCT
eurjchem-371	365	5	12	12	NUM
eurjchem-371	365	6	,	,	PUNCT
eurjchem-371	365	7	1369–1377	1369–1377	NUM
eurjchem-371	365	8	.	.	PUNCT
eurjchem-371	366	1	[	[	X
eurjchem-371	366	2	30	30	NUM
eurjchem-371	366	3	]	]	PUNCT
eurjchem-371	366	4	.	.	PUNCT
eurjchem-371	367	1	wishart	wishart	PROPN
eurjchem-371	367	2	,	,	PUNCT
eurjchem-371	367	3	d.	d.	PROPN
eurjchem-371	367	4	s.	s.	PROPN
eurjchem-371	367	5	;	;	PUNCT
eurjchem-371	367	6	knox	knox	PROPN
eurjchem-371	367	7	,	,	PUNCT
eurjchem-371	367	8	c.	c.	PROPN
eurjchem-371	367	9	;	;	PUNCT
eurjchem-371	367	10	guo	guo	PROPN
eurjchem-371	367	11	,	,	PUNCT
eurjchem-371	367	12	a.	a.	PROPN
eurjchem-371	367	13	c.	c.	PROPN
eurjchem-371	367	14	;	;	PUNCT
eurjchem-371	367	15	cheng	cheng	PROPN
eurjchem-371	367	16	,	,	PUNCT
eurjchem-371	367	17	d.	d.	PROPN
eurjchem-371	367	18	;	;	PUNCT
eurjchem-371	367	19	shrivastava	shrivastava	PROPN
eurjchem-371	367	20	,	,	PUNCT
eurjchem-371	367	21	s.	s.	PROPN
eurjchem-371	367	22	;	;	PUNCT
eurjchem-371	367	23	tzur	tzur	VERB
eurjchem-371	367	24	,	,	PUNCT
eurjchem-371	367	25	d.	d.	PROPN
eurjchem-371	367	26	;	;	PUNCT
eurjchem-371	367	27	gautam	gautam	PROPN
eurjchem-371	367	28	,	,	PUNCT
eurjchem-371	367	29	b.	b.	PROPN
eurjchem-371	367	30	;	;	PUNCT
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eurjchem-371	367	32	,	,	PUNCT
eurjchem-371	367	33	m.	m.	NOUN
eurjchem-371	367	34	;	;	PUNCT
eurjchem-371	367	35	drugbank	drugbank	NOUN
eurjchem-371	367	36	:	:	PUNCT
eurjchem-371	367	37	nucleic	nucleic	ADJ
eurjchem-371	367	38	acids	acid	NOUN
eurjchem-371	367	39	res	re	NOUN
eurjchem-371	367	40	.	.	PUNCT
eurjchem-371	367	41	2008	2008	NUM
eurjchem-371	367	42	,	,	PUNCT
eurjchem-371	367	43	36	36	NUM
eurjchem-371	367	44	(	(	PUNCT
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eurjchem-371	367	47	.	.	PUNCT
eurjchem-371	368	1	[	[	X
eurjchem-371	368	2	31	31	NUM
eurjchem-371	368	3	]	]	PUNCT
eurjchem-371	368	4	.	.	PUNCT
eurjchem-371	369	1	arnaud‐neu	arnaud‐neu	PROPN
eurjchem-371	369	2	,	,	PUNCT
eurjchem-371	369	3	f.	f.	PROPN
eurjchem-371	369	4	;	;	PUNCT
eurjchem-371	369	5	delgado	delgado	PROPN
eurjchem-371	369	6	,	,	PUNCT
eurjchem-371	369	7	r.	r.	PROPN
eurjchem-371	369	8	;	;	PUNCT
eurjchem-371	369	9	chaves	chave	NOUN
eurjchem-371	369	10	,	,	PUNCT
eurjchem-371	369	11	s.	s.	PROPN
eurjchem-371	369	12	pure	pure	PROPN
eurjchem-371	369	13	appl	appl	PROPN
eurjchem-371	369	14	.	.	PUNCT
eurjchem-371	369	15	chem	chem	PROPN
eurjchem-371	369	16	.	.	PUNCT
eurjchem-371	370	1	2003	2003	NUM
eurjchem-371	370	2	,	,	PUNCT
eurjchem-371	370	3	75	75	NUM
eurjchem-371	370	4	,	,	PUNCT
eurjchem-371	370	5	71	71	NUM
eurjchem-371	370	6	–	–	PUNCT
eurjchem-371	370	7	102	102	NUM
eurjchem-371	370	8	.	.	PUNCT
eurjchem-371	371	1	[	[	X
eurjchem-371	371	2	32	32	NUM
eurjchem-371	371	3	]	]	PUNCT
eurjchem-371	371	4	.	.	PUNCT
eurjchem-371	372	1	gutmann	gutmann	PROPN
eurjchem-371	372	2	,	,	PUNCT
eurjchem-371	372	3	v.	v.	ADP
eurjchem-371	372	4	coord	coord	NOUN
eurjchem-371	372	5	.	.	PUNCT
eurjchem-371	373	1	chem	chem	PROPN
eurjchem-371	373	2	.	.	PUNCT
eurjchem-371	374	1	rev	rev	PROPN
eurjchem-371	374	2	.	.	PROPN
eurjchem-371	374	3	1976	1976	NUM
eurjchem-371	374	4	,	,	PUNCT
eurjchem-371	374	5	18	18	NUM
eurjchem-371	374	6	,	,	PUNCT
eurjchem-371	374	7	225‐255	225‐255	NUM
eurjchem-371	374	8	.	.	PUNCT
eurjchem-371	375	1	[	[	X
eurjchem-371	375	2	33	33	NUM
eurjchem-371	375	3	]	]	PUNCT
eurjchem-371	375	4	.	.	PUNCT
eurjchem-371	376	1	loudon	loudon	PROPN
eurjchem-371	376	2	,	,	PUNCT
eurjchem-371	376	3	g.	g.	PROPN
eurjchem-371	376	4	m.	m.	PROPN
eurjchem-371	376	5	organic	organic	ADJ
eurjchem-371	376	6	chemistry	chemistry	NOUN
eurjchem-371	376	7	,	,	PUNCT
eurjchem-371	376	8	4th	4th	ADJ
eurjchem-371	376	9	edition	edition	NOUN
eurjchem-371	376	10	,	,	PUNCT
eurjchem-371	376	11	oxford	oxford	PROPN
eurjchem-371	376	12	university	university	PROPN
eurjchem-371	376	13	press	press	NOUN
eurjchem-371	376	14	,	,	PUNCT
eurjchem-371	376	15	2005	2005	NUM
eurjchem-371	376	16	.	.	PUNCT
eurjchem-371	377	1	[	[	X
eurjchem-371	377	2	34	34	NUM
eurjchem-371	377	3	]	]	PUNCT
eurjchem-371	377	4	.	.	PUNCT
eurjchem-371	378	1	coetzee	coetzee	PROPN
eurjchem-371	378	2	,	,	PUNCT
eurjchem-371	378	3	j.	j.	PROPN
eurjchem-371	378	4	f.	f.	PROPN
eurjchem-371	378	5	;	;	PUNCT
eurjchem-371	378	6	padmanabhan	padmanabhan	PROPN
eurjchem-371	378	7	,	,	PUNCT
eurjchem-371	378	8	g.	g.	PROPN
eurjchem-371	378	9	r.	r.	PROPN
eurjchem-371	378	10	j.	j.	PROPN
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eurjchem-371	378	12	.	.	PROPN
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eurjchem-371	378	14	.	.	PUNCT
eurjchem-371	379	1	soc	soc	PROPN
eurjchem-371	379	2	.	.	PUNCT
eurjchem-371	380	1	1965	1965	NUM
eurjchem-371	380	2	,	,	PUNCT
eurjchem-371	380	3	87	87	NUM
eurjchem-371	380	4	,	,	PUNCT
eurjchem-371	380	5	5005‐	5005‐	NUM
eurjchem-371	380	6	5010	5010	NUM
eurjchem-371	380	7	.	.	PUNCT
eurjchem-371	381	1	[	[	X
eurjchem-371	381	2	35	35	NUM
eurjchem-371	381	3	]	]	PUNCT
eurjchem-371	381	4	.	.	PUNCT
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eurjchem-371	381	10	development	development	NOUN
eurjchem-371	381	11	.	.	PUNCT
eurjchem-371	382	1	solubility	solubility	NOUN
eurjchem-371	382	2	,	,	PUNCT
eurjchem-371	382	3	permeability	permeability	NOUN
eurjchem-371	382	4	and	and	CCONJ
eurjchem-371	382	5	charge	charge	NOUN
eurjchem-371	382	6	state	state	NOUN
eurjchem-371	382	7	,	,	PUNCT
eurjchem-371	382	8	wiley	wiley	PROPN
eurjchem-371	382	9	&	&	CCONJ
eurjchem-371	382	10	sons	son	NOUN
eurjchem-371	382	11	,	,	PUNCT
eurjchem-371	382	12	new	new	PROPN
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eurjchem-371	382	14	,	,	PUNCT
eurjchem-371	382	15	2003	2003	NUM
eurjchem-371	382	16	.	.	PUNCT