id	sid	tid	token	lemma	pos
eurjchem-596	1	1	untitled	untitle	VERB
eurjchem-596	1	2	european	european	PROPN
eurjchem-596	1	3	journal	journal	PROPN
eurjchem-596	1	4	of	of	ADP
eurjchem-596	1	5	chemistry	chemistry	NOUN
eurjchem-596	1	6	3	3	NUM
eurjchem-596	1	7	(	(	PUNCT
eurjchem-596	1	8	2	2	NUM
eurjchem-596	1	9	)	)	PUNCT
eurjchem-596	1	10	(	(	PUNCT
eurjchem-596	1	11	2012	2012	NUM
eurjchem-596	1	12	)	)	PUNCT
eurjchem-596	1	13	228‐234	228‐234	PROPN
eurjchem-596	1	14	european	european	PROPN
eurjchem-596	1	15	journal	journal	PROPN
eurjchem-596	1	16	of	of	ADP
eurjchem-596	1	17	chemistry	chemistry	NOUN
eurjchem-596	1	18	issn	issn	PROPN
eurjchem-596	1	19	2153‐2249	2153‐2249	PROPN
eurjchem-596	1	20	(	(	PUNCT
eurjchem-596	1	21	print	print	NOUN
eurjchem-596	1	22	)	)	PUNCT
eurjchem-596	1	23	/	/	SYM
eurjchem-596	1	24	issn	issn	PROPN
eurjchem-596	1	25	2153‐2257	2153‐2257	NUM
eurjchem-596	1	26	(	(	PUNCT
eurjchem-596	1	27	online	online	ADJ
eurjchem-596	1	28	)	)	PUNCT
eurjchem-596	1	29			NOUN
eurjchem-596	1	30	2012	2012	NUM
eurjchem-596	1	31	eurjchem	eurjchem	PROPN
eurjchem-596	1	32	doi:10.5155	doi:10.5155	NOUN
eurjchem-596	1	33	/	/	SYM
eurjchem-596	1	34	eurjchem.3.2.228‐234.596	eurjchem.3.2.228‐234.596	ADJ
eurjchem-596	1	35	european	european	ADJ
eurjchem-596	1	36	journal	journal	PROPN
eurjchem-596	1	37	of	of	ADP
eurjchem-596	1	38	chemistry	chemistry	PROPN
eurjchem-596	1	39	journal	journal	PROPN
eurjchem-596	1	40	homepage	homepage	NOUN
eurjchem-596	1	41	:	:	PUNCT
eurjchem-596	1	42	www.eurjchem.com	www.eurjchem.com	X
eurjchem-596	1	43	in‐vitro	in‐vitro	VERB
eurjchem-596	1	44	cytotoxic	cytotoxic	ADJ
eurjchem-596	1	45	and	and	CCONJ
eurjchem-596	1	46	radiosensitizing	radiosensitize	VERB
eurjchem-596	1	47	evaluation	evaluation	NOUN
eurjchem-596	1	48	of	of	ADP
eurjchem-596	1	49	novel	novel	NOUN
eurjchem-596	1	50	2‐pyridone	2‐pyridone	NUM
eurjchem-596	1	51	,	,	PUNCT
eurjchem-596	1	52	isoquinoline	isoquinoline	ADJ
eurjchem-596	1	53	,	,	PUNCT
eurjchem-596	1	54	chromene	chromene	NOUN
eurjchem-596	1	55	and	and	CCONJ
eurjchem-596	1	56	chromenopyridone	chromenopyridone	NOUN
eurjchem-596	1	57	derivatives	derivative	NOUN
eurjchem-596	1	58	mansour	mansour	PROPN
eurjchem-596	1	59	sulaiman	sulaiman	PROPN
eurjchem-596	1	60	al‐saida	al‐saida	PROPN
eurjchem-596	1	61	,	,	PUNCT
eurjchem-596	1	62	marwa	marwa	PROPN
eurjchem-596	1	63	galal	galal	PROPN
eurjchem-596	1	64	el‐gazzarb	el‐gazzarb	PROPN
eurjchem-596	1	65	and	and	CCONJ
eurjchem-596	1	66	mostafa	mostafa	PROPN
eurjchem-596	1	67	mohammed	mohammed	PROPN
eurjchem-596	1	68	ghoraba	ghoraba	PROPN
eurjchem-596	1	69	,	,	PUNCT
eurjchem-596	1	70	*	*	PUNCT
eurjchem-596	1	71	a	a	DET
eurjchem-596	1	72	medicinal	medicinal	ADJ
eurjchem-596	1	73	,	,	PUNCT
eurjchem-596	1	74	aromatic	aromatic	ADJ
eurjchem-596	1	75	and	and	CCONJ
eurjchem-596	1	76	poisonous	poisonous	ADJ
eurjchem-596	1	77	plants	plant	NOUN
eurjchem-596	1	78	research	research	NOUN
eurjchem-596	1	79	center	center	NOUN
eurjchem-596	1	80	,	,	PUNCT
eurjchem-596	1	81	college	college	NOUN
eurjchem-596	1	82	of	of	ADP
eurjchem-596	1	83	pharmacy	pharmacy	NOUN
eurjchem-596	1	84	,	,	PUNCT
eurjchem-596	1	85	king	king	PROPN
eurjchem-596	1	86	saud	saud	PROPN
eurjchem-596	1	87	university	university	PROPN
eurjchem-596	1	88	,	,	PUNCT
eurjchem-596	1	89	riyadh	riyadh	PROPN
eurjchem-596	1	90	,	,	PUNCT
eurjchem-596	1	91	11451	11451	NUM
eurjchem-596	1	92	,	,	PUNCT
eurjchem-596	1	93	saudi	saudi	PROPN
eurjchem-596	1	94	arabia	arabia	PROPN
eurjchem-596	1	95	b	b	PROPN
eurjchem-596	1	96	department	department	PROPN
eurjchem-596	1	97	of	of	ADP
eurjchem-596	1	98	drug	drug	NOUN
eurjchem-596	1	99	radiation	radiation	NOUN
eurjchem-596	1	100	research	research	NOUN
eurjchem-596	1	101	,	,	PUNCT
eurjchem-596	1	102	national	national	ADJ
eurjchem-596	1	103	center	center	NOUN
eurjchem-596	1	104	for	for	ADP
eurjchem-596	1	105	radiation	radiation	NOUN
eurjchem-596	1	106	research	research	NOUN
eurjchem-596	1	107	and	and	CCONJ
eurjchem-596	1	108	technology	technology	NOUN
eurjchem-596	1	109	,	,	PUNCT
eurjchem-596	1	110	nasr	nasr	PROPN
eurjchem-596	1	111	city	city	PROPN
eurjchem-596	1	112	,	,	PUNCT
eurjchem-596	1	113	cairo	cairo	PROPN
eurjchem-596	1	114	,	,	PUNCT
eurjchem-596	1	115	11371	11371	NUM
eurjchem-596	1	116	,	,	PUNCT
eurjchem-596	1	117	egypt	egypt	PROPN
eurjchem-596	1	118	*	*	PUNCT
eurjchem-596	1	119	corresponding	correspond	VERB
eurjchem-596	1	120	author	author	NOUN
eurjchem-596	1	121	at	at	ADP
eurjchem-596	1	122	:	:	PUNCT
eurjchem-596	1	123	medicinal	medicinal	ADJ
eurjchem-596	1	124	,	,	PUNCT
eurjchem-596	1	125	aromatic	aromatic	ADJ
eurjchem-596	1	126	and	and	CCONJ
eurjchem-596	1	127	poisonous	poisonous	ADJ
eurjchem-596	1	128	plants	plant	NOUN
eurjchem-596	1	129	research	research	NOUN
eurjchem-596	1	130	center	center	NOUN
eurjchem-596	1	131	,	,	PUNCT
eurjchem-596	1	132	college	college	NOUN
eurjchem-596	1	133	of	of	ADP
eurjchem-596	1	134	pharmacy	pharmacy	NOUN
eurjchem-596	1	135	,	,	PUNCT
eurjchem-596	1	136	king	king	PROPN
eurjchem-596	1	137	saud	saud	PROPN
eurjchem-596	1	138	university	university	PROPN
eurjchem-596	1	139	,	,	PUNCT
eurjchem-596	1	140	riyadh	riyadh	PROPN
eurjchem-596	1	141	,	,	PUNCT
eurjchem-596	1	142	11451	11451	NUM
eurjchem-596	1	143	,	,	PUNCT
eurjchem-596	1	144	saudi	saudi	PROPN
eurjchem-596	1	145	arabia	arabia	PROPN
eurjchem-596	1	146	.	.	PUNCT
eurjchem-596	2	1	tel	tel	PROPN
eurjchem-596	2	2	.	.	PUNCT
eurjchem-596	2	3	:	:	PUNCT
eurjchem-596	3	1	+966.05.34292860	+966.05.34292860	NOUN
eurjchem-596	3	2	;	;	PUNCT
eurjchem-596	3	3	fax	fax	NOUN
eurjchem-596	3	4	:	:	PUNCT
eurjchem-596	3	5	+966.01.4670560	+966.01.4670560	PROPN
eurjchem-596	3	6	.	.	PUNCT
eurjchem-596	3	7	e‐mail	e‐mail	PUNCT
eurjchem-596	4	1	address	address	NOUN
eurjchem-596	4	2	:	:	PUNCT
eurjchem-596	4	3	mmsghorab@yahoo.com	mmsghorab@yahoo.com	X
eurjchem-596	4	4	(	(	PUNCT
eurjchem-596	4	5	m.m	m.m	PROPN
eurjchem-596	4	6	.	.	PROPN
eurjchem-596	4	7	ghorab	ghorab	PROPN
eurjchem-596	4	8	)	)	PUNCT
eurjchem-596	4	9	.	.	PUNCT
eurjchem-596	5	1	article	article	NOUN
eurjchem-596	5	2	information	information	PROPN
eurjchem-596	5	3	abstract	abstract	ADV
eurjchem-596	5	4	received	receive	VERB
eurjchem-596	5	5	:	:	PUNCT
eurjchem-596	5	6	10	10	NUM
eurjchem-596	5	7	february	february	NOUN
eurjchem-596	5	8	2012	2012	NUM
eurjchem-596	5	9	received	receive	VERB
eurjchem-596	5	10	in	in	ADP
eurjchem-596	5	11	revised	revise	VERB
eurjchem-596	5	12	form	form	NOUN
eurjchem-596	5	13	:	:	PUNCT
eurjchem-596	5	14	16	16	NUM
eurjchem-596	5	15	march	march	PROPN
eurjchem-596	5	16	2012	2012	NUM
eurjchem-596	5	17	accepted	accept	VERB
eurjchem-596	5	18	:	:	PUNCT
eurjchem-596	5	19	28	28	NUM
eurjchem-596	5	20	march	march	NOUN
eurjchem-596	5	21	2012	2012	NUM
eurjchem-596	5	22	online	online	NOUN
eurjchem-596	5	23	:	:	PUNCT
eurjchem-596	5	24	30	30	NUM
eurjchem-596	5	25	june	june	PROPN
eurjchem-596	5	26	2012	2012	NUM
eurjchem-596	5	27	keywords	keyword	NOUN
eurjchem-596	5	28	on	on	ADP
eurjchem-596	5	29	the	the	DET
eurjchem-596	5	30	account	account	NOUN
eurjchem-596	5	31	of	of	ADP
eurjchem-596	5	32	the	the	DET
eurjchem-596	5	33	reported	report	VERB
eurjchem-596	5	34	anticancer	anticancer	NOUN
eurjchem-596	5	35	activity	activity	NOUN
eurjchem-596	5	36	of	of	ADP
eurjchem-596	5	37	2‐pyridone	2‐pyridone	NUM
eurjchem-596	5	38	,	,	PUNCT
eurjchem-596	5	39	a	a	DET
eurjchem-596	5	40	new	new	ADJ
eurjchem-596	5	41	series	series	NOUN
eurjchem-596	5	42	of	of	ADP
eurjchem-596	5	43	ethyl‐1,6‐	ethyl‐1,6‐	PROPN
eurjchem-596	5	44	dihydropyridine‐3‐carboxylate	dihydropyridine‐3‐carboxylate	PROPN
eurjchem-596	5	45	(	(	PUNCT
eurjchem-596	5	46	4a‐j	4a‐j	NOUN
eurjchem-596	5	47	)	)	PUNCT
eurjchem-596	5	48	,	,	PUNCT
eurjchem-596	5	49	1‐oxo‐1,2‐dihydroisoquinoline‐7‐carbonitrile	1‐oxo‐1,2‐dihydroisoquinoline‐7‐carbonitrile	PROPN
eurjchem-596	5	50	(	(	PUNCT
eurjchem-596	5	51	6a‐h	6a‐h	NOUN
eurjchem-596	5	52	)	)	PUNCT
eurjchem-596	5	53	,	,	PUNCT
eurjchem-596	5	54	2h‐chromene	2h‐chromene	NUM
eurjchem-596	5	55	(	(	PUNCT
eurjchem-596	5	56	7,8	7,8	NUM
eurjchem-596	5	57	)	)	PUNCT
eurjchem-596	5	58	and	and	CCONJ
eurjchem-596	5	59	3h‐chromeno[3,4‐c]pyridone	3h‐chromeno[3,4‐c]pyridone	NUM
eurjchem-596	5	60	derivatives	derivative	NOUN
eurjchem-596	5	61	(	(	PUNCT
eurjchem-596	5	62	9,10	9,10	NUM
eurjchem-596	5	63	)	)	PUNCT
eurjchem-596	5	64	were	be	AUX
eurjchem-596	5	65	synthesized	synthesize	VERB
eurjchem-596	5	66	and	and	CCONJ
eurjchem-596	5	67	tested	test	VERB
eurjchem-596	5	68	for	for	ADP
eurjchem-596	5	69	in‐vitro	in‐vitro	NOUN
eurjchem-596	5	70	anticancer	anticancer	NOUN
eurjchem-596	5	71	activity	activity	NOUN
eurjchem-596	5	72	against	against	ADP
eurjchem-596	5	73	ehrlich	ehrlich	NOUN
eurjchem-596	5	74	ascites	ascite	NOUN
eurjchem-596	5	75	carcinoma	carcinoma	NOUN
eurjchem-596	5	76	(	(	PUNCT
eurjchem-596	5	77	eac	eac	PROPN
eurjchem-596	5	78	)	)	PUNCT
eurjchem-596	5	79	cell	cell	NOUN
eurjchem-596	5	80	line	line	NOUN
eurjchem-596	5	81	and	and	CCONJ
eurjchem-596	5	82	human	human	ADJ
eurjchem-596	5	83	liver	liver	NOUN
eurjchem-596	5	84	cell	cell	NOUN
eurjchem-596	5	85	line	line	NOUN
eurjchem-596	5	86	(	(	PUNCT
eurjchem-596	5	87	hepg2	hepg2	NOUN
eurjchem-596	5	88	)	)	PUNCT
eurjchem-596	5	89	.	.	PUNCT
eurjchem-596	6	1	the	the	DET
eurjchem-596	6	2	structures	structure	NOUN
eurjchem-596	6	3	of	of	ADP
eurjchem-596	6	4	the	the	DET
eurjchem-596	6	5	synthesized	synthesize	VERB
eurjchem-596	6	6	compounds	compound	NOUN
eurjchem-596	6	7	were	be	AUX
eurjchem-596	6	8	confirmed	confirm	VERB
eurjchem-596	6	9	by	by	ADP
eurjchem-596	6	10	analytical	analytical	ADJ
eurjchem-596	6	11	and	and	CCONJ
eurjchem-596	6	12	spectral	spectral	ADJ
eurjchem-596	6	13	data	datum	NOUN
eurjchem-596	6	14	.	.	PUNCT
eurjchem-596	7	1	furthermore	furthermore	ADV
eurjchem-596	7	2	,	,	PUNCT
eurjchem-596	7	3	radiosensitization	radiosensitization	NOUN
eurjchem-596	7	4	study	study	NOUN
eurjchem-596	7	5	was	be	AUX
eurjchem-596	7	6	performed	perform	VERB
eurjchem-596	7	7	for	for	ADP
eurjchem-596	7	8	the	the	DET
eurjchem-596	7	9	most	most	ADV
eurjchem-596	7	10	potent	potent	ADJ
eurjchem-596	7	11	compounds	compound	NOUN
eurjchem-596	7	12	(	(	PUNCT
eurjchem-596	7	13	4a	4a	NOUN
eurjchem-596	7	14	,	,	PUNCT
eurjchem-596	7	15	4d	4d	NUM
eurjchem-596	7	16	,	,	PUNCT
eurjchem-596	7	17	6a	6a	NOUN
eurjchem-596	7	18	,	,	PUNCT
eurjchem-596	7	19	6c	6c	NOUN
eurjchem-596	7	20	,	,	PUNCT
eurjchem-596	7	21	6e	6e	NUM
eurjchem-596	7	22	and	and	CCONJ
eurjchem-596	7	23	10	10	NUM
eurjchem-596	7	24	)	)	PUNCT
eurjchem-596	7	25	.	.	PUNCT
eurjchem-596	8	1	cytotoxic	cytotoxic	ADJ
eurjchem-596	8	2	chromene	chromene	NOUN
eurjchem-596	8	3	2‐pyridone	2‐pyridone	NUM
eurjchem-596	8	4	isoquinoline	isoquinoline	ADJ
eurjchem-596	8	5	radiosensitizing	radiosensitize	VERB
eurjchem-596	8	6	chromenopyridone	chromenopyridone	NOUN
eurjchem-596	8	7	1	1	NUM
eurjchem-596	8	8	.	.	PUNCT
eurjchem-596	9	1	introduction	introduction	NOUN
eurjchem-596	9	2	compounds	compound	NOUN
eurjchem-596	9	3	containing	contain	VERB
eurjchem-596	9	4	2‐pyridone	2‐pyridone	NUM
eurjchem-596	9	5	moiety	moiety	NOUN
eurjchem-596	9	6	i‐iv	i‐iv	NOUN
eurjchem-596	9	7	as	as	ADP
eurjchem-596	9	8	a	a	DET
eurjchem-596	9	9	precursor	precursor	NOUN
eurjchem-596	9	10	have	have	AUX
eurjchem-596	9	11	proven	prove	VERB
eurjchem-596	9	12	to	to	PART
eurjchem-596	9	13	possess	possess	VERB
eurjchem-596	9	14	several	several	ADJ
eurjchem-596	9	15	biologically	biologically	NOUN
eurjchem-596	9	16	properties	property	NOUN
eurjchem-596	9	17	(	(	PUNCT
eurjchem-596	9	18	scheme	scheme	NOUN
eurjchem-596	9	19	1	1	NUM
eurjchem-596	9	20	)	)	PUNCT
eurjchem-596	10	1	[	[	X
eurjchem-596	10	2	1‐6	1‐6	NOUN
eurjchem-596	10	3	]	]	PUNCT
eurjchem-596	10	4	.	.	PUNCT
eurjchem-596	11	1	in	in	ADP
eurjchem-596	11	2	addition	addition	NOUN
eurjchem-596	11	3	,	,	PUNCT
eurjchem-596	11	4	different	different	ADJ
eurjchem-596	11	5	series	series	NOUN
eurjchem-596	11	6	of	of	ADP
eurjchem-596	11	7	isoquinoline	isoquinoline	NOUN
eurjchem-596	11	8	containing	contain	VERB
eurjchem-596	11	9	compounds	compound	NOUN
eurjchem-596	11	10	v	v	NUM
eurjchem-596	11	11	were	be	AUX
eurjchem-596	11	12	reported	report	VERB
eurjchem-596	11	13	to	to	PART
eurjchem-596	11	14	possess	possess	VERB
eurjchem-596	11	15	substantial	substantial	ADJ
eurjchem-596	11	16	cytotoxicity	cytotoxicity	NOUN
eurjchem-596	11	17	[	[	X
eurjchem-596	11	18	7	7	NUM
eurjchem-596	11	19	]	]	PUNCT
eurjchem-596	11	20	.	.	PUNCT
eurjchem-596	12	1	furthermore	furthermore	ADV
eurjchem-596	12	2	,	,	PUNCT
eurjchem-596	12	3	novel	novel	ADJ
eurjchem-596	12	4	classes	class	NOUN
eurjchem-596	12	5	of	of	ADP
eurjchem-596	12	6	chromenes	chromene	NOUN
eurjchem-596	12	7	bearing	bear	VERB
eurjchem-596	12	8	dithiazole	dithiazole	NOUN
eurjchem-596	12	9	vi	vi	PROPN
eurjchem-596	12	10	or	or	CCONJ
eurjchem-596	12	11	phenylthioamide	phenylthioamide	NOUN
eurjchem-596	12	12	vii	vii	PROPN
eurjchem-596	12	13	moieties	moiety	NOUN
eurjchem-596	12	14	showed	show	VERB
eurjchem-596	12	15	potent	potent	ADJ
eurjchem-596	12	16	cytotoxicity	cytotoxicity	NOUN
eurjchem-596	12	17	[	[	X
eurjchem-596	12	18	8	8	NUM
eurjchem-596	12	19	]	]	PUNCT
eurjchem-596	12	20	,	,	PUNCT
eurjchem-596	12	21	while	while	SCONJ
eurjchem-596	12	22	chromene‐	chromene‐	NOUN
eurjchem-596	12	23	carboxamides	carboxamide	VERB
eurjchem-596	12	24	viii	viii	ADJ
eurjchem-596	12	25	and	and	CCONJ
eurjchem-596	12	26	carboxylates	carboxylate	NOUN
eurjchem-596	12	27	proved	prove	VERB
eurjchem-596	12	28	potent	potent	ADJ
eurjchem-596	12	29	anticancer	anticancer	NOUN
eurjchem-596	12	30	activity	activity	NOUN
eurjchem-596	12	31	on	on	ADP
eurjchem-596	12	32	different	different	ADJ
eurjchem-596	12	33	cell	cell	NOUN
eurjchem-596	12	34	lines	line	NOUN
eurjchem-596	12	35	and	and	CCONJ
eurjchem-596	12	36	as	as	ADP
eurjchem-596	12	37	inhibitors	inhibitor	NOUN
eurjchem-596	12	38	of	of	ADP
eurjchem-596	12	39	tumor	tumor	NOUN
eurjchem-596	12	40	markers	marker	NOUN
eurjchem-596	13	1	[	[	X
eurjchem-596	13	2	9,10	9,10	NUM
eurjchem-596	13	3	]	]	PUNCT
eurjchem-596	13	4	.	.	PUNCT
eurjchem-596	14	1	based	base	VERB
eurjchem-596	14	2	on	on	ADP
eurjchem-596	14	3	the	the	DET
eurjchem-596	14	4	above	above	ADJ
eurjchem-596	14	5	information	information	NOUN
eurjchem-596	14	6	and	and	CCONJ
eurjchem-596	14	7	as	as	ADP
eurjchem-596	14	8	a	a	DET
eurjchem-596	14	9	continuation	continuation	NOUN
eurjchem-596	14	10	of	of	ADP
eurjchem-596	14	11	a	a	DET
eurjchem-596	14	12	previous	previous	ADJ
eurjchem-596	14	13	work	work	NOUN
eurjchem-596	14	14	on	on	ADP
eurjchem-596	14	15	anticancer	anticancer	NOUN
eurjchem-596	14	16	agents	agent	NOUN
eurjchem-596	14	17	[	[	X
eurjchem-596	14	18	11‐16	11‐16	NUM
eurjchem-596	14	19	]	]	PUNCT
eurjchem-596	14	20	,	,	PUNCT
eurjchem-596	14	21	we	we	PRON
eurjchem-596	14	22	report	report	VERB
eurjchem-596	14	23	the	the	DET
eurjchem-596	14	24	synthesis	synthesis	NOUN
eurjchem-596	14	25	of	of	ADP
eurjchem-596	14	26	novel	novel	NOUN
eurjchem-596	14	27	2‐pyridone	2‐pyridone	NUM
eurjchem-596	14	28	,	,	PUNCT
eurjchem-596	14	29	isoquinoline	isoquinoline	ADJ
eurjchem-596	14	30	,	,	PUNCT
eurjchem-596	14	31	chromene	chromene	NOUN
eurjchem-596	14	32	and	and	CCONJ
eurjchem-596	14	33	chromenopyridone	chromenopyridone	NOUN
eurjchem-596	14	34	as	as	ADP
eurjchem-596	14	35	cytotoxic	cytotoxic	ADJ
eurjchem-596	14	36	and	and	CCONJ
eurjchem-596	14	37	radiosensitizing	radiosensitize	VERB
eurjchem-596	14	38	agents	agent	NOUN
eurjchem-596	14	39	.	.	PUNCT
eurjchem-596	15	1	2	2	X
eurjchem-596	15	2	.	.	X
eurjchem-596	15	3	experimental	experimental	ADJ
eurjchem-596	15	4	2.1	2.1	NUM
eurjchem-596	15	5	.	.	PUNCT
eurjchem-596	16	1	instrumentation	instrumentation	NOUN
eurjchem-596	16	2	chemicals	chemical	NOUN
eurjchem-596	16	3	were	be	AUX
eurjchem-596	16	4	purchased	purchase	VERB
eurjchem-596	16	5	from	from	ADP
eurjchem-596	16	6	merck	merck	PROPN
eurjchem-596	16	7	,	,	PUNCT
eurjchem-596	16	8	fluka	fluka	NOUN
eurjchem-596	16	9	and	and	CCONJ
eurjchem-596	16	10	aldrich	aldrich	PROPN
eurjchem-596	16	11	chemical	chemical	NOUN
eurjchem-596	16	12	companies	company	NOUN
eurjchem-596	16	13	.	.	PUNCT
eurjchem-596	17	1	all	all	DET
eurjchem-596	17	2	yields	yield	NOUN
eurjchem-596	17	3	refer	refer	VERB
eurjchem-596	17	4	to	to	ADP
eurjchem-596	17	5	isolated	isolated	ADJ
eurjchem-596	17	6	products	product	NOUN
eurjchem-596	17	7	.	.	PUNCT
eurjchem-596	18	1	melting	melt	VERB
eurjchem-596	18	2	points	point	NOUN
eurjchem-596	18	3	are	be	AUX
eurjchem-596	18	4	uncorrected	uncorrecte	VERB
eurjchem-596	18	5	and	and	CCONJ
eurjchem-596	18	6	were	be	AUX
eurjchem-596	18	7	determined	determine	VERB
eurjchem-596	18	8	on	on	ADP
eurjchem-596	18	9	a	a	DET
eurjchem-596	18	10	stuart	stuart	PROPN
eurjchem-596	18	11	melting	melting	NOUN
eurjchem-596	18	12	point	point	NOUN
eurjchem-596	18	13	apparatus	apparatus	NOUN
eurjchem-596	18	14	(	(	PUNCT
eurjchem-596	18	15	stuart	stuart	PROPN
eurjchem-596	18	16	scientific	scientific	PROPN
eurjchem-596	18	17	,	,	PUNCT
eurjchem-596	18	18	redhill	redhill	NOUN
eurjchem-596	18	19	,	,	PUNCT
eurjchem-596	18	20	uk	uk	PROPN
eurjchem-596	18	21	)	)	PUNCT
eurjchem-596	18	22	.	.	PUNCT
eurjchem-596	19	1	elemental	elemental	ADJ
eurjchem-596	19	2	analysis	analysis	NOUN
eurjchem-596	19	3	(	(	PUNCT
eurjchem-596	19	4	c	c	NOUN
eurjchem-596	19	5	,	,	PUNCT
eurjchem-596	19	6	h	h	NOUN
eurjchem-596	19	7	and	and	CCONJ
eurjchem-596	19	8	n	n	CCONJ
eurjchem-596	19	9	)	)	PUNCT
eurjchem-596	19	10	were	be	AUX
eurjchem-596	19	11	performed	perform	VERB
eurjchem-596	19	12	on	on	ADP
eurjchem-596	19	13	perkin‐	perkin‐	NOUN
eurjchem-596	19	14	elmer	elmer	PROPN
eurjchem-596	19	15	2400	2400	NUM
eurjchem-596	19	16	analyser	analyser	NOUN
eurjchem-596	19	17	(	(	PUNCT
eurjchem-596	19	18	perkin‐elmer	perkin‐elmer	PROPN
eurjchem-596	19	19	,	,	PUNCT
eurjchem-596	19	20	norwalk	norwalk	NOUN
eurjchem-596	19	21	,	,	PUNCT
eurjchem-596	19	22	ct	ct	PROPN
eurjchem-596	19	23	,	,	PUNCT
eurjchem-596	19	24	usa	usa	PROPN
eurjchem-596	19	25	)	)	PUNCT
eurjchem-596	19	26	at	at	ADP
eurjchem-596	19	27	the	the	DET
eurjchem-596	19	28	microanalytical	microanalytical	ADJ
eurjchem-596	19	29	laboratories	laboratory	NOUN
eurjchem-596	19	30	of	of	ADP
eurjchem-596	19	31	the	the	DET
eurjchem-596	19	32	faculty	faculty	NOUN
eurjchem-596	19	33	of	of	ADP
eurjchem-596	19	34	science	science	NOUN
eurjchem-596	19	35	,	,	PUNCT
eurjchem-596	19	36	cairo	cairo	PROPN
eurjchem-596	19	37	university	university	PROPN
eurjchem-596	19	38	.	.	PUNCT
eurjchem-596	20	1	all	all	DET
eurjchem-596	20	2	compounds	compound	NOUN
eurjchem-596	20	3	were	be	AUX
eurjchem-596	20	4	within	within	ADP
eurjchem-596	20	5	±0.4	±0.4	PROPN
eurjchem-596	20	6	%	%	NOUN
eurjchem-596	20	7	of	of	ADP
eurjchem-596	20	8	the	the	DET
eurjchem-596	20	9	theoretical	theoretical	ADJ
eurjchem-596	20	10	values	value	NOUN
eurjchem-596	20	11	.	.	PUNCT
eurjchem-596	21	1	the	the	DET
eurjchem-596	21	2	ir	ir	PROPN
eurjchem-596	21	3	spectra	spectra	PROPN
eurjchem-596	21	4	(	(	PUNCT
eurjchem-596	21	5	kbr	kbr	PROPN
eurjchem-596	21	6	)	)	PUNCT
eurjchem-596	21	7	were	be	AUX
eurjchem-596	21	8	measured	measure	VERB
eurjchem-596	21	9	on	on	ADP
eurjchem-596	21	10	shimadzu	shimadzu	PROPN
eurjchem-596	21	11	ir	ir	PROPN
eurjchem-596	21	12	110	110	NUM
eurjchem-596	21	13	spectrophotometer	spectrophotometer	NOUN
eurjchem-596	21	14	(	(	PUNCT
eurjchem-596	21	15	shimadzu	shimadzu	PROPN
eurjchem-596	21	16	,	,	PUNCT
eurjchem-596	21	17	koyoto	koyoto	NOUN
eurjchem-596	21	18	,	,	PUNCT
eurjchem-596	21	19	japan	japan	PROPN
eurjchem-596	21	20	)	)	PUNCT
eurjchem-596	21	21	.	.	PUNCT
eurjchem-596	22	1	1h	1h	NUM
eurjchem-596	22	2	nmr	nmr	PROPN
eurjchem-596	22	3	spectra	spectra	NOUN
eurjchem-596	22	4	were	be	AUX
eurjchem-596	22	5	obtained	obtain	VERB
eurjchem-596	22	6	on	on	ADP
eurjchem-596	22	7	a	a	DET
eurjchem-596	22	8	bruker	bruker	ADJ
eurjchem-596	22	9	proton	proton	NOUN
eurjchem-596	22	10	nmr‐avance	nmr‐avance	NOUN
eurjchem-596	22	11	300	300	NUM
eurjchem-596	22	12	(	(	PUNCT
eurjchem-596	22	13	300	300	NUM
eurjchem-596	22	14	mhz	mhz	NOUN
eurjchem-596	22	15	)	)	PUNCT
eurjchem-596	22	16	(	(	PUNCT
eurjchem-596	22	17	bruker	bruker	PROPN
eurjchem-596	22	18	,	,	PUNCT
eurjchem-596	22	19	munich	munich	PROPN
eurjchem-596	22	20	,	,	PUNCT
eurjchem-596	22	21	germany	germany	PROPN
eurjchem-596	22	22	)	)	PUNCT
eurjchem-596	22	23	,	,	PUNCT
eurjchem-596	22	24	in	in	ADP
eurjchem-596	22	25	dmso‐d6	dmso‐d6	PROPN
eurjchem-596	22	26	as	as	ADP
eurjchem-596	22	27	a	a	DET
eurjchem-596	22	28	solvent	solvent	NOUN
eurjchem-596	22	29	,	,	PUNCT
eurjchem-596	22	30	using	use	VERB
eurjchem-596	22	31	tetramethylsilane	tetramethylsilane	PROPN
eurjchem-596	22	32	(	(	PUNCT
eurjchem-596	22	33	tms	tms	PROPN
eurjchem-596	22	34	)	)	PUNCT
eurjchem-596	22	35	as	as	ADP
eurjchem-596	22	36	internal	internal	ADJ
eurjchem-596	22	37	standard	standard	NOUN
eurjchem-596	22	38	.	.	PUNCT
eurjchem-596	23	1	mass	mass	PROPN
eurjchem-596	23	2	spectra	spectra	PROPN
eurjchem-596	23	3	were	be	AUX
eurjchem-596	23	4	run	run	VERB
eurjchem-596	23	5	on	on	ADP
eurjchem-596	23	6	hp	hp	PROPN
eurjchem-596	23	7	model	model	NOUN
eurjchem-596	23	8	ms‐5988	ms‐5988	PROPN
eurjchem-596	23	9	(	(	PUNCT
eurjchem-596	23	10	hewlett	hewlett	PROPN
eurjchem-596	23	11	packard	packard	PROPN
eurjchem-596	23	12	,	,	PUNCT
eurjchem-596	23	13	palo	palo	PROPN
eurjchem-596	23	14	,	,	PUNCT
eurjchem-596	23	15	alto	alto	PROPN
eurjchem-596	23	16	,	,	PUNCT
eurjchem-596	23	17	california	california	PROPN
eurjchem-596	23	18	,	,	PUNCT
eurjchem-596	23	19	usa	usa	PROPN
eurjchem-596	23	20	)	)	PUNCT
eurjchem-596	23	21	.	.	PUNCT
eurjchem-596	24	1	all	all	DET
eurjchem-596	24	2	reactions	reaction	NOUN
eurjchem-596	24	3	were	be	AUX
eurjchem-596	24	4	monitored	monitor	VERB
eurjchem-596	24	5	by	by	ADP
eurjchem-596	24	6	thin	thin	ADJ
eurjchem-596	24	7	layer	layer	NOUN
eurjchem-596	24	8	chromatograph	chromatograph	NOUN
eurjchem-596	24	9	(	(	PUNCT
eurjchem-596	24	10	tlc	tlc	NOUN
eurjchem-596	24	11	)	)	PUNCT
eurjchem-596	24	12	using	use	VERB
eurjchem-596	24	13	precoated	precoate	VERB
eurjchem-596	24	14	aluminium	aluminium	NOUN
eurjchem-596	24	15	sheets	sheet	NOUN
eurjchem-596	24	16	silica	silica	NOUN
eurjchem-596	24	17	gel	gel	PROPN
eurjchem-596	24	18	merck	merck	PROPN
eurjchem-596	24	19	60f254	60f254	PROPN
eurjchem-596	24	20	and	and	CCONJ
eurjchem-596	24	21	were	be	AUX
eurjchem-596	24	22	visualized	visualize	VERB
eurjchem-596	24	23	by	by	ADP
eurjchem-596	24	24	uv	uv	NOUN
eurjchem-596	24	25	lamp	lamp	NOUN
eurjchem-596	24	26	(	(	PUNCT
eurjchem-596	24	27	merck	merck	PROPN
eurjchem-596	24	28	,	,	PUNCT
eurjchem-596	24	29	darmstadt	darmstadt	PROPN
eurjchem-596	24	30	,	,	PUNCT
eurjchem-596	24	31	germany	germany	PROPN
eurjchem-596	24	32	)	)	PUNCT
eurjchem-596	24	33	.	.	PUNCT
eurjchem-596	25	1	2.2	2.2	NUM
eurjchem-596	25	2	.	.	PUNCT
eurjchem-596	25	3	synthesis	synthesis	NOUN
eurjchem-596	25	4	2.2.1	2.2.1	NUM
eurjchem-596	25	5	.	.	PUNCT
eurjchem-596	25	6	2‐	2‐	NUM
eurjchem-596	25	7	cyano‐n‐(3‐ethylphenyl)acetamide	cyano‐n‐(3‐ethylphenyl)acetamide	NOUN
eurjchem-596	25	8	(	(	PUNCT
eurjchem-596	25	9	3	3	NUM
eurjchem-596	25	10	)	)	PUNCT
eurjchem-596	25	11	a	a	DET
eurjchem-596	25	12	mixture	mixture	NOUN
eurjchem-596	25	13	of	of	ADP
eurjchem-596	25	14	3‐ethylaniline	3‐ethylaniline	NUM
eurjchem-596	25	15	,	,	PUNCT
eurjchem-596	25	16	1	1	NUM
eurjchem-596	25	17	,	,	PUNCT
eurjchem-596	25	18	(	(	PUNCT
eurjchem-596	25	19	1.21	1.21	NUM
eurjchem-596	25	20	g	g	NOUN
eurjchem-596	25	21	,	,	PUNCT
eurjchem-596	25	22	0.01	0.01	NUM
eurjchem-596	25	23	mol	mol	NOUN
eurjchem-596	25	24	)	)	PUNCT
eurjchem-596	25	25	and	and	CCONJ
eurjchem-596	25	26	ethyl	ethyl	PROPN
eurjchem-596	25	27	cyanoacetate	cyanoacetate	NOUN
eurjchem-596	25	28	(	(	PUNCT
eurjchem-596	25	29	1.13	1.13	NUM
eurjchem-596	25	30	g	g	NOUN
eurjchem-596	25	31	,	,	PUNCT
eurjchem-596	25	32	0.01	0.01	NUM
eurjchem-596	25	33	mol	mol	NOUN
eurjchem-596	25	34	)	)	PUNCT
eurjchem-596	25	35	was	be	AUX
eurjchem-596	25	36	refluxed	refluxe	VERB
eurjchem-596	25	37	for	for	ADP
eurjchem-596	25	38	3	3	NUM
eurjchem-596	25	39	h.	h.	NOUN
eurjchem-596	25	40	the	the	DET
eurjchem-596	25	41	reaction	reaction	NOUN
eurjchem-596	25	42	mixture	mixture	NOUN
eurjchem-596	25	43	was	be	AUX
eurjchem-596	25	44	concentrated	concentrate	VERB
eurjchem-596	25	45	and	and	CCONJ
eurjchem-596	25	46	cooled	cool	VERB
eurjchem-596	25	47	.	.	PUNCT
eurjchem-596	26	1	the	the	DET
eurjchem-596	26	2	obtained	obtain	VERB
eurjchem-596	26	3	product	product	NOUN
eurjchem-596	26	4	was	be	AUX
eurjchem-596	26	5	crystallized	crystallize	VERB
eurjchem-596	26	6	from	from	ADP
eurjchem-596	26	7	ethanol	ethanol	NOUN
eurjchem-596	26	8	to	to	PART
eurjchem-596	26	9	give	give	VERB
eurjchem-596	26	10	compound	compound	NOUN
eurjchem-596	26	11	3	3	NUM
eurjchem-596	26	12	(	(	PUNCT
eurjchem-596	26	13	scheme	scheme	NOUN
eurjchem-596	26	14	2	2	NUM
eurjchem-596	26	15	)	)	PUNCT
eurjchem-596	26	16	.	.	PUNCT
eurjchem-596	27	1	yield	yield	NOUN
eurjchem-596	27	2	:	:	PUNCT
eurjchem-596	27	3	88	88	NUM
eurjchem-596	27	4	%	%	NOUN
eurjchem-596	27	5	.	.	PUNCT
eurjchem-596	28	1	m.p	m.p	PROPN
eurjchem-596	28	2	.	.	PROPN
eurjchem-596	28	3	:	:	PUNCT
eurjchem-596	28	4	86‐88	86‐88	NUM
eurjchem-596	28	5	c	c	ADJ
eurjchem-596	28	6	.	.	PUNCT
eurjchem-596	29	1	ir	ir	PROPN
eurjchem-596	29	2	(	(	PUNCT
eurjchem-596	29	3	kbr	kbr	PROPN
eurjchem-596	29	4	,	,	PUNCT
eurjchem-596	29	5	ν	ν	PROPN
eurjchem-596	29	6	,	,	PUNCT
eurjchem-596	29	7	cm–1	cm–1	PROPN
eurjchem-596	29	8	):	):	PUNCT
eurjchem-596	29	9	3317	3317	NUM
eurjchem-596	29	10	(	(	PUNCT
eurjchem-596	29	11	nh	nh	NOUN
eurjchem-596	29	12	)	)	PUNCT
eurjchem-596	29	13	,	,	PUNCT
eurjchem-596	29	14	3100	3100	NUM
eurjchem-596	29	15	(	(	PUNCT
eurjchem-596	29	16	ch	ch	NOUN
eurjchem-596	29	17	.	.	PUNCT
eurjchem-596	30	1	arom	arom	PROPN
eurjchem-596	30	2	.	.	PUNCT
eurjchem-596	30	3	)	)	PUNCT
eurjchem-596	31	1	,	,	PUNCT
eurjchem-596	32	1	2960	2960	NUM
eurjchem-596	32	2	,	,	PUNCT
eurjchem-596	32	3	2870	2870	NUM
eurjchem-596	32	4	(	(	PUNCT
eurjchem-596	32	5	ch	ch	NOUN
eurjchem-596	32	6	aliph	aliph	PROPN
eurjchem-596	32	7	.	.	PUNCT
eurjchem-596	32	8	)	)	PUNCT
eurjchem-596	32	9	,	,	PUNCT
eurjchem-596	32	10	2260	2260	NUM
eurjchem-596	32	11	(	(	PUNCT
eurjchem-596	32	12	c≡n	c≡n	PROPN
eurjchem-596	32	13	)	)	PUNCT
eurjchem-596	32	14	,	,	PUNCT
eurjchem-596	32	15	1670	1670	NUM
eurjchem-596	32	16	(	(	PUNCT
eurjchem-596	32	17	c	c	NOUN
eurjchem-596	32	18	=	=	NOUN
eurjchem-596	32	19	o	o	NOUN
eurjchem-596	32	20	)	)	PUNCT
eurjchem-596	32	21	.	.	PUNCT
eurjchem-596	33	1	1h	1h	NUM
eurjchem-596	33	2	nmr	nmr	NOUN
eurjchem-596	33	3	(	(	PUNCT
eurjchem-596	33	4	300	300	NUM
eurjchem-596	33	5	mhz	mhz	NOUN
eurjchem-596	33	6	,	,	PUNCT
eurjchem-596	33	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	33	8	,	,	PUNCT
eurjchem-596	33	9			NUM
eurjchem-596	33	10	,	,	PUNCT
eurjchem-596	33	11	ppm	ppm	NUM
eurjchem-596	33	12	):	):	PUNCT
eurjchem-596	33	13	1.2	1.2	NUM
eurjchem-596	33	14	(	(	PUNCT
eurjchem-596	33	15	t	t	PROPN
eurjchem-596	33	16	,	,	PUNCT
eurjchem-596	33	17	3h	3h	NUM
eurjchem-596	33	18	,	,	PUNCT
eurjchem-596	33	19	ch3	ch3	PROPN
eurjchem-596	33	20	,	,	PUNCT
eurjchem-596	33	21	j	j	PROPN
eurjchem-596	33	22	=	=	PROPN
eurjchem-596	33	23	0.66	0.66	NUM
eurjchem-596	33	24	hz	hz	NOUN
eurjchem-596	33	25	)	)	PUNCT
eurjchem-596	33	26	,	,	PUNCT
eurjchem-596	33	27	2.6	2.6	NUM
eurjchem-596	33	28	(	(	PUNCT
eurjchem-596	33	29	q	q	NOUN
eurjchem-596	33	30	,	,	PUNCT
eurjchem-596	33	31	2h	2h	NUM
eurjchem-596	33	32	,	,	PUNCT
eurjchem-596	33	33	ch2	ch2	PROPN
eurjchem-596	33	34	,	,	PUNCT
eurjchem-596	33	35	j	j	PROPN
eurjchem-596	33	36	=	=	PROPN
eurjchem-596	33	37	0.66	0.66	NUM
eurjchem-596	33	38	hz	hz	NOUN
eurjchem-596	33	39	)	)	PUNCT
eurjchem-596	33	40	,	,	PUNCT
eurjchem-596	33	41	3.6	3.6	NUM
eurjchem-596	33	42	(	(	PUNCT
eurjchem-596	33	43	s	s	PROPN
eurjchem-596	33	44	,	,	PUNCT
eurjchem-596	33	45	2h	2h	NUM
eurjchem-596	33	46	,	,	PUNCT
eurjchem-596	33	47	ch2	ch2	PROPN
eurjchem-596	33	48	)	)	PUNCT
eurjchem-596	33	49	,	,	PUNCT
eurjchem-596	33	50	4.2	4.2	NUM
eurjchem-596	33	51	(	(	PUNCT
eurjchem-596	33	52	s	s	PROPN
eurjchem-596	33	53	,	,	PUNCT
eurjchem-596	33	54	1h	1h	NUM
eurjchem-596	33	55	,	,	PUNCT
eurjchem-596	33	56	nh	nh	PROPN
eurjchem-596	33	57	,	,	PUNCT
eurjchem-596	33	58	exchangeable	exchangeable	ADJ
eurjchem-596	33	59	with	with	ADP
eurjchem-596	33	60	d2o	d2o	NOUN
eurjchem-596	33	61	)	)	PUNCT
eurjchem-596	33	62	,	,	PUNCT
eurjchem-596	33	63	7.0‐7.7	7.0‐7.7	NUM
eurjchem-596	33	64	(	(	PUNCT
eurjchem-596	33	65	m	m	PROPN
eurjchem-596	33	66	,	,	PUNCT
eurjchem-596	33	67	4h	4h	NOUN
eurjchem-596	33	68	,	,	PUNCT
eurjchem-596	33	69	ar‐h	ar‐h	PROPN
eurjchem-596	33	70	)	)	PUNCT
eurjchem-596	33	71	.	.	PUNCT
eurjchem-596	34	1	13c	13c	NOUN
eurjchem-596	34	2	nmr	nmr	NOUN
eurjchem-596	34	3	(	(	PUNCT
eurjchem-596	34	4	75	75	NUM
eurjchem-596	34	5	mhz	mhz	NOUN
eurjchem-596	34	6	,	,	PUNCT
eurjchem-596	34	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	34	8	,	,	PUNCT
eurjchem-596	34	9			NUM
eurjchem-596	34	10	,	,	PUNCT
eurjchem-596	34	11	ppm	ppm	NUM
eurjchem-596	34	12	):	):	PUNCT
eurjchem-596	34	13	13.6	13.6	NUM
eurjchem-596	34	14	,	,	PUNCT
eurjchem-596	34	15	26.1	26.1	NUM
eurjchem-596	34	16	,	,	PUNCT
eurjchem-596	34	17	32.9	32.9	NUM
eurjchem-596	34	18	,	,	PUNCT
eurjchem-596	34	19	117.4	117.4	NUM
eurjchem-596	34	20	,	,	PUNCT
eurjchem-596	34	21	119.2	119.2	NUM
eurjchem-596	34	22	,	,	PUNCT
eurjchem-596	34	23	122.0	122.0	NUM
eurjchem-596	34	24	,	,	PUNCT
eurjchem-596	34	25	125.6	125.6	NUM
eurjchem-596	34	26	,	,	PUNCT
eurjchem-596	34	27	129.7	129.7	NUM
eurjchem-596	34	28	,	,	PUNCT
eurjchem-596	34	29	140.8	140.8	NUM
eurjchem-596	34	30	,	,	PUNCT
eurjchem-596	34	31	142.5	142.5	NUM
eurjchem-596	34	32	,	,	PUNCT
eurjchem-596	34	33	169.6	169.6	NUM
eurjchem-596	34	34	.	.	PUNCT
eurjchem-596	35	1	anal	anal	ADJ
eurjchem-596	35	2	.	.	PUNCT
eurjchem-596	35	3	calcd	calcd	NOUN
eurjchem-596	35	4	.	.	PUNCT
eurjchem-596	36	1	for	for	ADP
eurjchem-596	36	2	c11h12n2o	c11h12n2o	ADJ
eurjchem-596	36	3	:	:	PUNCT
eurjchem-596	36	4	c	c	X
eurjchem-596	36	5	,	,	PUNCT
eurjchem-596	36	6	70.19	70.19	NUM
eurjchem-596	36	7	;	;	PUNCT
eurjchem-596	36	8	h	h	NOUN
eurjchem-596	36	9	,	,	PUNCT
eurjchem-596	36	10	6.38	6.38	NUM
eurjchem-596	36	11	,	,	PUNCT
eurjchem-596	36	12	14.88	14.88	NUM
eurjchem-596	36	13	.	.	PUNCT
eurjchem-596	36	14	found	find	VERB
eurjchem-596	36	15	:	:	PUNCT
eurjchem-596	37	1	c	c	X
eurjchem-596	37	2	,	,	PUNCT
eurjchem-596	37	3	70.50	70.50	NUM
eurjchem-596	37	4	;	;	PUNCT
eurjchem-596	37	5	h	h	NOUN
eurjchem-596	37	6	,	,	PUNCT
eurjchem-596	37	7	6.10	6.10	NUM
eurjchem-596	37	8	;	;	PUNCT
eurjchem-596	37	9	n	n	CCONJ
eurjchem-596	37	10	,	,	PUNCT
eurjchem-596	37	11	14.60	14.60	NUM
eurjchem-596	37	12	%	%	NOUN
eurjchem-596	37	13	.	.	PUNCT
eurjchem-596	38	1	2.2.2	2.2.2	X
eurjchem-596	38	2	.	.	PUNCT
eurjchem-596	39	1	ethyl	ethyl	PROPN
eurjchem-596	39	2	4‐substituted‐2‐amino‐5‐cyano‐1‐(3‐ethyl	4‐substituted‐2‐amino‐5‐cyano‐1‐(3‐ethyl	PROPN
eurjchem-596	40	1	phenyl)‐6‐oxo‐1,6‐dihydropyridine‐3‐carboxylate	phenyl)‐6‐oxo‐1,6‐dihydropyridine‐3‐carboxylate	PROPN
eurjchem-596	40	2	(	(	PUNCT
eurjchem-596	40	3	4a‐j	4a‐j	NOUN
eurjchem-596	40	4	)	)	PUNCT
eurjchem-596	40	5	general	general	ADJ
eurjchem-596	40	6	procedure	procedure	NOUN
eurjchem-596	40	7	:	:	PUNCT
eurjchem-596	40	8	a	a	DET
eurjchem-596	40	9	mixture	mixture	NOUN
eurjchem-596	40	10	of	of	ADP
eurjchem-596	40	11	compound	compound	NOUN
eurjchem-596	40	12	3	3	NUM
eurjchem-596	40	13	(	(	PUNCT
eurjchem-596	40	14	1.88	1.88	NUM
eurjchem-596	40	15	g	g	NOUN
eurjchem-596	40	16	,	,	PUNCT
eurjchem-596	40	17	0.01	0.01	NUM
eurjchem-596	40	18	mol	mol	NOUN
eurjchem-596	40	19	)	)	PUNCT
eurjchem-596	40	20	,	,	PUNCT
eurjchem-596	40	21	appropriate	appropriate	ADJ
eurjchem-596	40	22	aldehyde	aldehyde	NOUN
eurjchem-596	40	23	(	(	PUNCT
eurjchem-596	40	24	0.01	0.01	NUM
eurjchem-596	40	25	mol	mol	NOUN
eurjchem-596	40	26	)	)	PUNCT
eurjchem-596	40	27	and	and	CCONJ
eurjchem-596	40	28	ethyl	ethyl	PROPN
eurjchem-596	40	29	cyanoacetate	cyanoacetate	NOUN
eurjchem-596	40	30	(	(	PUNCT
eurjchem-596	40	31	0.113	0.113	NUM
eurjchem-596	40	32	g	g	NOUN
eurjchem-596	40	33	,	,	PUNCT
eurjchem-596	40	34	0.01	0.01	NUM
eurjchem-596	40	35	mol	mol	NOUN
eurjchem-596	40	36	)	)	PUNCT
eurjchem-596	40	37	in	in	ADP
eurjchem-596	40	38	ethanol	ethanol	NOUN
eurjchem-596	40	39	(	(	PUNCT
eurjchem-596	40	40	50	50	NUM
eurjchem-596	40	41	ml	ml	NOUN
eurjchem-596	40	42	)	)	PUNCT
eurjchem-596	40	43	containing	contain	VERB
eurjchem-596	40	44	a	a	DET
eurjchem-596	40	45	catalytic	catalytic	ADJ
eurjchem-596	40	46	amount	amount	NOUN
eurjchem-596	40	47	of	of	ADP
eurjchem-596	40	48	piperidine	piperidine	NOUN
eurjchem-596	40	49	was	be	AUX
eurjchem-596	40	50	refluxed	refluxe	VERB
eurjchem-596	40	51	for	for	ADP
eurjchem-596	40	52	4	4	NUM
eurjchem-596	40	53	h.	h.	NOUN
eurjchem-596	40	54	the	the	PRON
eurjchem-596	40	55	obtained	obtain	VERB
eurjchem-596	40	56	solid	solid	ADJ
eurjchem-596	40	57	was	be	AUX
eurjchem-596	40	58	recrystallized	recrystallize	VERB
eurjchem-596	40	59	from	from	ADP
eurjchem-596	40	60	dioxane	dioxane	NOUN
eurjchem-596	40	61	to	to	PART
eurjchem-596	40	62	give	give	VERB
eurjchem-596	40	63	4a‐j	4a‐j	NOUN
eurjchem-596	40	64	(	(	PUNCT
eurjchem-596	40	65	scheme	scheme	NOUN
eurjchem-596	40	66	2	2	NUM
eurjchem-596	40	67	)	)	PUNCT
eurjchem-596	40	68	,	,	PUNCT
eurjchem-596	40	69	respectively	respectively	ADV
eurjchem-596	40	70	.	.	PUNCT
eurjchem-596	41	1	al‐said	al‐said	PROPN
eurjchem-596	41	2	et	et	PROPN
eurjchem-596	41	3	al	al	PROPN
eurjchem-596	41	4	.	.	PUNCT
eurjchem-596	41	5	/	/	SYM
eurjchem-596	41	6	european	european	PROPN
eurjchem-596	41	7	journal	journal	PROPN
eurjchem-596	41	8	of	of	ADP
eurjchem-596	41	9	chemistry	chemistry	NOUN
eurjchem-596	41	10	3	3	NUM
eurjchem-596	41	11	(	(	PUNCT
eurjchem-596	41	12	2	2	NUM
eurjchem-596	41	13	)	)	PUNCT
eurjchem-596	41	14	(	(	PUNCT
eurjchem-596	41	15	2012	2012	NUM
eurjchem-596	41	16	)	)	PUNCT
eurjchem-596	41	17	228‐234	228‐234	PROPN
eurjchem-596	41	18	229	229	NUM
eurjchem-596	41	19	scheme	scheme	NOUN
eurjchem-596	41	20	1	1	NUM
eurjchem-596	41	21	ethyl	ethyl	PROPN
eurjchem-596	41	22	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐p‐tolyl‐1,6‐	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐p‐tolyl‐1,6‐	PROPN
eurjchem-596	41	23	dihydro‐pyridine‐3‐carboxylate	dihydro‐pyridine‐3‐carboxylate	PROPN
eurjchem-596	41	24	(	(	PUNCT
eurjchem-596	41	25	4a	4a	NUM
eurjchem-596	41	26	):	):	PUNCT
eurjchem-596	41	27	yield	yield	NOUN
eurjchem-596	41	28	:	:	PUNCT
eurjchem-596	41	29	71	71	NUM
eurjchem-596	41	30	%	%	NOUN
eurjchem-596	41	31	.	.	PUNCT
eurjchem-596	42	1	m.p	m.p	PROPN
eurjchem-596	42	2	.	.	PROPN
eurjchem-596	42	3	:	:	PUNCT
eurjchem-596	43	1	248‐250	248‐250	NUM
eurjchem-596	43	2	c	c	ADJ
eurjchem-596	43	3	.	.	PUNCT
eurjchem-596	44	1	ir	ir	PROPN
eurjchem-596	44	2	(	(	PUNCT
eurjchem-596	44	3	kbr	kbr	PROPN
eurjchem-596	44	4	,	,	PUNCT
eurjchem-596	44	5	ν	ν	PROPN
eurjchem-596	44	6	,	,	PUNCT
eurjchem-596	44	7	cm–1	cm–1	PROPN
eurjchem-596	44	8	):	):	PUNCT
eurjchem-596	44	9	3309	3309	NUM
eurjchem-596	44	10	,	,	PUNCT
eurjchem-596	44	11	3207	3207	NUM
eurjchem-596	44	12	(	(	PUNCT
eurjchem-596	44	13	nh2	nh2	PROPN
eurjchem-596	44	14	)	)	PUNCT
eurjchem-596	44	15	,	,	PUNCT
eurjchem-596	44	16	3059	3059	NUM
eurjchem-596	44	17	(	(	PUNCT
eurjchem-596	44	18	ch	ch	NOUN
eurjchem-596	44	19	arom	arom	NOUN
eurjchem-596	44	20	.	.	PUNCT
eurjchem-596	44	21	)	)	PUNCT
eurjchem-596	44	22	,	,	PUNCT
eurjchem-596	44	23	2966	2966	NUM
eurjchem-596	44	24	,	,	PUNCT
eurjchem-596	44	25	2875	2875	NUM
eurjchem-596	44	26	(	(	PUNCT
eurjchem-596	44	27	ch	ch	NOUN
eurjchem-596	44	28	aliph	aliph	PROPN
eurjchem-596	44	29	.	.	PUNCT
eurjchem-596	44	30	)	)	PUNCT
eurjchem-596	44	31	,	,	PUNCT
eurjchem-596	44	32	2214	2214	NUM
eurjchem-596	44	33	(	(	PUNCT
eurjchem-596	44	34	c≡n	c≡n	PROPN
eurjchem-596	44	35	)	)	PUNCT
eurjchem-596	44	36	,	,	PUNCT
eurjchem-596	44	37	1676	1676	NUM
eurjchem-596	44	38	,	,	PUNCT
eurjchem-596	44	39	1687	1687	NUM
eurjchem-596	44	40	(	(	PUNCT
eurjchem-596	44	41	2c	2c	NOUN
eurjchem-596	44	42	=	=	SYM
eurjchem-596	44	43	o	o	NOUN
eurjchem-596	44	44	)	)	PUNCT
eurjchem-596	44	45	.	.	PUNCT
eurjchem-596	45	1	1h	1h	NUM
eurjchem-596	45	2	nmr	nmr	NOUN
eurjchem-596	45	3	(	(	PUNCT
eurjchem-596	45	4	300	300	NUM
eurjchem-596	45	5	mhz	mhz	NOUN
eurjchem-596	45	6	,	,	PUNCT
eurjchem-596	45	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	45	8	,	,	PUNCT
eurjchem-596	45	9			NUM
eurjchem-596	45	10	,	,	PUNCT
eurjchem-596	45	11	ppm	ppm	NUM
eurjchem-596	45	12	):	):	PUNCT
eurjchem-596	45	13	1.1	1.1	NUM
eurjchem-596	45	14	(	(	PUNCT
eurjchem-596	45	15	t	t	PROPN
eurjchem-596	45	16	,	,	PUNCT
eurjchem-596	45	17	3h	3h	NUM
eurjchem-596	45	18	,	,	PUNCT
eurjchem-596	45	19	ch3	ch3	PROPN
eurjchem-596	45	20	,	,	PUNCT
eurjchem-596	45	21	j	j	PROPN
eurjchem-596	45	22	=	=	SYM
eurjchem-596	45	23	0.1	0.1	NUM
eurjchem-596	45	24	hz	hz	NOUN
eurjchem-596	45	25	)	)	PUNCT
eurjchem-596	45	26	,	,	PUNCT
eurjchem-596	45	27	1.3	1.3	NUM
eurjchem-596	45	28	(	(	PUNCT
eurjchem-596	45	29	t	t	PROPN
eurjchem-596	45	30	,	,	PUNCT
eurjchem-596	45	31	3h	3h	NUM
eurjchem-596	45	32	,	,	PUNCT
eurjchem-596	45	33	ch3	ch3	PROPN
eurjchem-596	45	34	,	,	PUNCT
eurjchem-596	45	35	j	j	PROPN
eurjchem-596	45	36	=	=	PROPN
eurjchem-596	45	37	0.66	0.66	NUM
eurjchem-596	45	38	hz	hz	NOUN
eurjchem-596	45	39	)	)	PUNCT
eurjchem-596	45	40	,	,	PUNCT
eurjchem-596	45	41	1.9	1.9	NUM
eurjchem-596	45	42	(	(	PUNCT
eurjchem-596	45	43	s	s	PROPN
eurjchem-596	45	44	,	,	PUNCT
eurjchem-596	45	45	3h	3h	NUM
eurjchem-596	45	46	,	,	PUNCT
eurjchem-596	45	47	ch3	ch3	PROPN
eurjchem-596	45	48	)	)	PUNCT
eurjchem-596	45	49	,	,	PUNCT
eurjchem-596	45	50	2.6	2.6	NUM
eurjchem-596	45	51	(	(	PUNCT
eurjchem-596	45	52	q	q	NOUN
eurjchem-596	45	53	,	,	PUNCT
eurjchem-596	45	54	2h	2h	NUM
eurjchem-596	45	55	,	,	PUNCT
eurjchem-596	45	56	ch2	ch2	PROPN
eurjchem-596	45	57	,	,	PUNCT
eurjchem-596	45	58	j	j	PROPN
eurjchem-596	45	59	=	=	SYM
eurjchem-596	45	60	0.1	0.1	NUM
eurjchem-596	45	61	hz	hz	NOUN
eurjchem-596	45	62	)	)	PUNCT
eurjchem-596	45	63	,	,	PUNCT
eurjchem-596	45	64	4.3	4.3	NUM
eurjchem-596	45	65	(	(	PUNCT
eurjchem-596	45	66	q	q	NOUN
eurjchem-596	45	67	,	,	PUNCT
eurjchem-596	45	68	2h	2h	NUM
eurjchem-596	45	69	,	,	PUNCT
eurjchem-596	45	70	ch2	ch2	PROPN
eurjchem-596	45	71	,	,	PUNCT
eurjchem-596	45	72	j	j	PROPN
eurjchem-596	45	73	=	=	PROPN
eurjchem-596	45	74	0.66	0.66	NUM
eurjchem-596	45	75	hz	hz	NOUN
eurjchem-596	45	76	)	)	PUNCT
eurjchem-596	45	77	,	,	PUNCT
eurjchem-596	45	78	7.03‐7.7	7.03‐7.7	NUM
eurjchem-596	45	79	(	(	PUNCT
eurjchem-596	45	80	m	m	PROPN
eurjchem-596	45	81	,	,	PUNCT
eurjchem-596	45	82	8h	8h	NUM
eurjchem-596	45	83	,	,	PUNCT
eurjchem-596	45	84	ar‐h	ar‐h	PROPN
eurjchem-596	45	85	)	)	PUNCT
eurjchem-596	45	86	,	,	PUNCT
eurjchem-596	45	87	8.2	8.2	NUM
eurjchem-596	45	88	(	(	PUNCT
eurjchem-596	45	89	s	s	PROPN
eurjchem-596	45	90	,	,	PUNCT
eurjchem-596	45	91	2h	2h	NUM
eurjchem-596	45	92	,	,	PUNCT
eurjchem-596	45	93	nh2	nh2	PROPN
eurjchem-596	45	94	,	,	PUNCT
eurjchem-596	45	95	exchangeable	exchangeable	ADJ
eurjchem-596	45	96	with	with	ADP
eurjchem-596	45	97	d2o	d2o	NOUN
eurjchem-596	45	98	)	)	PUNCT
eurjchem-596	45	99	.	.	PUNCT
eurjchem-596	46	1	13c	13c	NOUN
eurjchem-596	46	2	nmr	nmr	NOUN
eurjchem-596	46	3	(	(	PUNCT
eurjchem-596	46	4	75	75	NUM
eurjchem-596	46	5	mhz	mhz	NOUN
eurjchem-596	46	6	,	,	PUNCT
eurjchem-596	46	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	46	8	,	,	PUNCT
eurjchem-596	46	9			NUM
eurjchem-596	46	10	,	,	PUNCT
eurjchem-596	46	11	ppm	ppm	NUM
eurjchem-596	46	12	):	):	PUNCT
eurjchem-596	46	13	13.4	13.4	NUM
eurjchem-596	46	14	,	,	PUNCT
eurjchem-596	46	15	15.2	15.2	NUM
eurjchem-596	46	16	,	,	PUNCT
eurjchem-596	46	17	25.1	25.1	NUM
eurjchem-596	46	18	,	,	PUNCT
eurjchem-596	46	19	31.9	31.9	NUM
eurjchem-596	46	20	,	,	PUNCT
eurjchem-596	46	21	62.9	62.9	NUM
eurjchem-596	46	22	,	,	PUNCT
eurjchem-596	46	23	86.1	86.1	NUM
eurjchem-596	46	24	,	,	PUNCT
eurjchem-596	46	25	114.3	114.3	NUM
eurjchem-596	46	26	,	,	PUNCT
eurjchem-596	46	27	115.0	115.0	NUM
eurjchem-596	46	28	,	,	PUNCT
eurjchem-596	46	29	117.3	117.3	NUM
eurjchem-596	46	30	,	,	PUNCT
eurjchem-596	46	31	119.8	119.8	NUM
eurjchem-596	46	32	,	,	PUNCT
eurjchem-596	46	33	122.1	122.1	NUM
eurjchem-596	46	34	,	,	PUNCT
eurjchem-596	46	35	125.8	125.8	NUM
eurjchem-596	46	36	,	,	PUNCT
eurjchem-596	46	37	127.4	127.4	NUM
eurjchem-596	46	38	,	,	PUNCT
eurjchem-596	46	39	130.6	130.6	NUM
eurjchem-596	46	40	,	,	PUNCT
eurjchem-596	46	41	131.0	131.0	NUM
eurjchem-596	46	42	,	,	PUNCT
eurjchem-596	46	43	133.2	133.2	NUM
eurjchem-596	46	44	,	,	PUNCT
eurjchem-596	46	45	136.7	136.7	NUM
eurjchem-596	46	46	,	,	PUNCT
eurjchem-596	46	47	140.9	140.9	NUM
eurjchem-596	46	48	,	,	PUNCT
eurjchem-596	46	49	162.7	162.7	NUM
eurjchem-596	46	50	,	,	PUNCT
eurjchem-596	46	51	163.2	163.2	NUM
eurjchem-596	46	52	,	,	PUNCT
eurjchem-596	46	53	164.8	164.8	NUM
eurjchem-596	46	54	,	,	PUNCT
eurjchem-596	46	55	168.7	168.7	NUM
eurjchem-596	46	56	.	.	PUNCT
eurjchem-596	47	1	ms	ms	PROPN
eurjchem-596	47	2	(	(	PUNCT
eurjchem-596	47	3	m	m	PROPN
eurjchem-596	47	4	/	/	SYM
eurjchem-596	47	5	z	z	NOUN
eurjchem-596	47	6	,	,	PUNCT
eurjchem-596	47	7	%	%	INTJ
eurjchem-596	47	8	):	):	PUNCT
eurjchem-596	47	9	401	401	NUM
eurjchem-596	47	10	(	(	PUNCT
eurjchem-596	47	11	m+	m+	NUM
eurjchem-596	47	12	,	,	PUNCT
eurjchem-596	47	13	5.1	5.1	NUM
eurjchem-596	47	14	)	)	PUNCT
eurjchem-596	47	15	,	,	PUNCT
eurjchem-596	47	16	90	90	NUM
eurjchem-596	47	17	(	(	PUNCT
eurjchem-596	47	18	100	100	NUM
eurjchem-596	47	19	)	)	PUNCT
eurjchem-596	47	20	.	.	PUNCT
eurjchem-596	48	1	anal	anal	PROPN
eurjchem-596	48	2	.	.	PUNCT
eurjchem-596	48	3	calcd	calcd	NOUN
eurjchem-596	48	4	.	.	PUNCT
eurjchem-596	49	1	for	for	ADP
eurjchem-596	49	2	c24h23n3o3	c24h23n3o3	NOUN
eurjchem-596	49	3	:	:	PUNCT
eurjchem-596	49	4	c	c	X
eurjchem-596	49	5	,	,	PUNCT
eurjchem-596	49	6	71.80	71.80	NUM
eurjchem-596	49	7	;	;	PUNCT
eurjchem-596	49	8	h	h	NOUN
eurjchem-596	49	9	,	,	PUNCT
eurjchem-596	49	10	5.77	5.77	NUM
eurjchem-596	49	11	;	;	PUNCT
eurjchem-596	49	12	n	n	CCONJ
eurjchem-596	49	13	,	,	PUNCT
eurjchem-596	49	14	10.47	10.47	NUM
eurjchem-596	49	15	.	.	PUNCT
eurjchem-596	49	16	found	find	VERB
eurjchem-596	49	17	:	:	PUNCT
eurjchem-596	50	1	c	c	X
eurjchem-596	50	2	,	,	PUNCT
eurjchem-596	50	3	71.40	71.40	NUM
eurjchem-596	50	4	;	;	PUNCT
eurjchem-596	51	1	h	h	NOUN
eurjchem-596	51	2	,	,	PUNCT
eurjchem-596	51	3	5.30	5.30	NUM
eurjchem-596	51	4	;	;	PUNCT
eurjchem-596	51	5	n	n	CCONJ
eurjchem-596	51	6	,	,	PUNCT
eurjchem-596	51	7	10.70	10.70	NUM
eurjchem-596	51	8	%	%	NOUN
eurjchem-596	51	9	.	.	PUNCT
eurjchem-596	52	1	ethyl	ethyl	PROPN
eurjchem-596	52	2	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(4‐	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(4‐	NUM
eurjchem-596	52	3	methoxyphenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	methoxyphenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	NOUN
eurjchem-596	52	4	(	(	PUNCT
eurjchem-596	52	5	4b	4b	X
eurjchem-596	52	6	):	):	PUNCT
eurjchem-596	52	7	yield	yield	NOUN
eurjchem-596	52	8	:	:	PUNCT
eurjchem-596	52	9	89	89	NUM
eurjchem-596	52	10	%	%	NOUN
eurjchem-596	52	11	.	.	PUNCT
eurjchem-596	53	1	m.p	m.p	PROPN
eurjchem-596	53	2	.	.	PROPN
eurjchem-596	53	3	:	:	PUNCT
eurjchem-596	54	1	>	>	PUNCT
eurjchem-596	54	2	300	300	NUM
eurjchem-596	54	3	c	c	VERB
eurjchem-596	54	4	.	.	PUNCT
eurjchem-596	55	1	ir	ir	PROPN
eurjchem-596	55	2	(	(	PUNCT
eurjchem-596	55	3	kbr	kbr	PROPN
eurjchem-596	55	4	,	,	PUNCT
eurjchem-596	55	5	ν	ν	PROPN
eurjchem-596	55	6	,	,	PUNCT
eurjchem-596	55	7	cm–1	cm–1	PROPN
eurjchem-596	55	8	):	):	PUNCT
eurjchem-596	55	9	3309	3309	NUM
eurjchem-596	55	10	,	,	PUNCT
eurjchem-596	55	11	3207	3207	NUM
eurjchem-596	55	12	(	(	PUNCT
eurjchem-596	55	13	nh2	nh2	PROPN
eurjchem-596	55	14	)	)	PUNCT
eurjchem-596	55	15	,	,	PUNCT
eurjchem-596	55	16	3088	3088	NUM
eurjchem-596	55	17	(	(	PUNCT
eurjchem-596	55	18	charom	charom	NOUN
eurjchem-596	55	19	.	.	PUNCT
eurjchem-596	55	20	)	)	PUNCT
eurjchem-596	55	21	,	,	PUNCT
eurjchem-596	55	22	2966	2966	NUM
eurjchem-596	55	23	,	,	PUNCT
eurjchem-596	55	24	2839	2839	NUM
eurjchem-596	55	25	(	(	PUNCT
eurjchem-596	55	26	ch	ch	NOUN
eurjchem-596	55	27	aliph	aliph	PROPN
eurjchem-596	55	28	.	.	PUNCT
eurjchem-596	55	29	)	)	PUNCT
eurjchem-596	55	30	,	,	PUNCT
eurjchem-596	55	31	2214	2214	NUM
eurjchem-596	55	32	(	(	PUNCT
eurjchem-596	55	33	c≡n	c≡n	PROPN
eurjchem-596	55	34	)	)	PUNCT
eurjchem-596	55	35	,	,	PUNCT
eurjchem-596	55	36	1676	1676	NUM
eurjchem-596	55	37	,	,	PUNCT
eurjchem-596	55	38	1680	1680	NUM
eurjchem-596	55	39	(	(	PUNCT
eurjchem-596	55	40	2c	2c	NOUN
eurjchem-596	55	41	=	=	SYM
eurjchem-596	55	42	o	o	NOUN
eurjchem-596	55	43	)	)	PUNCT
eurjchem-596	55	44	.	.	PUNCT
eurjchem-596	56	1	1h	1h	NUM
eurjchem-596	56	2	nmr	nmr	NOUN
eurjchem-596	56	3	(	(	PUNCT
eurjchem-596	56	4	300	300	NUM
eurjchem-596	56	5	mhz	mhz	NOUN
eurjchem-596	56	6	,	,	PUNCT
eurjchem-596	56	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	56	8	,	,	PUNCT
eurjchem-596	56	9			NUM
eurjchem-596	56	10	,	,	PUNCT
eurjchem-596	56	11	ppm	ppm	NUM
eurjchem-596	56	12	):	):	PUNCT
eurjchem-596	56	13	1.1	1.1	NUM
eurjchem-596	56	14	(	(	PUNCT
eurjchem-596	56	15	t	t	PROPN
eurjchem-596	56	16	,	,	PUNCT
eurjchem-596	56	17	3h	3h	NUM
eurjchem-596	56	18	,	,	PUNCT
eurjchem-596	56	19	ch3	ch3	PROPN
eurjchem-596	56	20	,	,	PUNCT
eurjchem-596	56	21	j	j	PROPN
eurjchem-596	56	22	=	=	SYM
eurjchem-596	56	23	0.1	0.1	NUM
eurjchem-596	56	24	hz	hz	NOUN
eurjchem-596	56	25	)	)	PUNCT
eurjchem-596	56	26	,	,	PUNCT
eurjchem-596	56	27	1.3	1.3	NUM
eurjchem-596	56	28	(	(	PUNCT
eurjchem-596	56	29	t	t	PROPN
eurjchem-596	56	30	,	,	PUNCT
eurjchem-596	56	31	3h	3h	NUM
eurjchem-596	56	32	,	,	PUNCT
eurjchem-596	56	33	ch3	ch3	PROPN
eurjchem-596	56	34	,	,	PUNCT
eurjchem-596	56	35	j	j	PROPN
eurjchem-596	56	36	=	=	PROPN
eurjchem-596	56	37	0.66	0.66	NUM
eurjchem-596	56	38	hz	hz	NOUN
eurjchem-596	56	39	)	)	PUNCT
eurjchem-596	56	40	,	,	PUNCT
eurjchem-596	56	41	2.6	2.6	NUM
eurjchem-596	56	42	(	(	PUNCT
eurjchem-596	56	43	q	q	NOUN
eurjchem-596	56	44	,	,	PUNCT
eurjchem-596	56	45	2h	2h	NUM
eurjchem-596	56	46	,	,	PUNCT
eurjchem-596	56	47	ch2	ch2	PROPN
eurjchem-596	56	48	,	,	PUNCT
eurjchem-596	56	49	j	j	PROPN
eurjchem-596	56	50	=	=	SYM
eurjchem-596	56	51	0.1	0.1	NUM
eurjchem-596	56	52	hz	hz	NOUN
eurjchem-596	56	53	)	)	PUNCT
eurjchem-596	56	54	,	,	PUNCT
eurjchem-596	56	55	3.5	3.5	NUM
eurjchem-596	56	56	(	(	PUNCT
eurjchem-596	56	57	s	s	PROPN
eurjchem-596	56	58	,	,	PUNCT
eurjchem-596	56	59	3h	3h	NUM
eurjchem-596	56	60	,	,	PUNCT
eurjchem-596	56	61	och3	och3	ADJ
eurjchem-596	56	62	)	)	PUNCT
eurjchem-596	56	63	,	,	PUNCT
eurjchem-596	56	64	4.3	4.3	NUM
eurjchem-596	56	65	(	(	PUNCT
eurjchem-596	56	66	q	q	NOUN
eurjchem-596	56	67	,	,	PUNCT
eurjchem-596	56	68	2h	2h	NUM
eurjchem-596	56	69	,	,	PUNCT
eurjchem-596	56	70	ch2	ch2	PROPN
eurjchem-596	56	71	,	,	PUNCT
eurjchem-596	56	72	j	j	PROPN
eurjchem-596	56	73	=	=	PROPN
eurjchem-596	56	74	0.66	0.66	NUM
eurjchem-596	56	75	hz	hz	NOUN
eurjchem-596	56	76	)	)	PUNCT
eurjchem-596	56	77	,	,	PUNCT
eurjchem-596	56	78	7.0‐7.7	7.0‐7.7	NUM
eurjchem-596	56	79	(	(	PUNCT
eurjchem-596	56	80	m	m	PROPN
eurjchem-596	56	81	,	,	PUNCT
eurjchem-596	56	82	8h	8h	NUM
eurjchem-596	56	83	,	,	PUNCT
eurjchem-596	56	84	ar‐h	ar‐h	PROPN
eurjchem-596	56	85	)	)	PUNCT
eurjchem-596	56	86	,	,	PUNCT
eurjchem-596	56	87	8.1	8.1	NUM
eurjchem-596	56	88	(	(	PUNCT
eurjchem-596	56	89	s	s	PROPN
eurjchem-596	56	90	,	,	PUNCT
eurjchem-596	56	91	2h	2h	NUM
eurjchem-596	56	92	,	,	PUNCT
eurjchem-596	56	93	nh2	nh2	PROPN
eurjchem-596	56	94	,	,	PUNCT
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eurjchem-596	56	96	with	with	ADP
eurjchem-596	56	97	d2o	d2o	NOUN
eurjchem-596	56	98	)	)	PUNCT
eurjchem-596	56	99	.	.	PUNCT
eurjchem-596	57	1	ms	ms	NOUN
eurjchem-596	57	2	(	(	PUNCT
eurjchem-596	57	3	m	m	PROPN
eurjchem-596	57	4	/	/	SYM
eurjchem-596	57	5	z	z	NOUN
eurjchem-596	57	6	,	,	PUNCT
eurjchem-596	57	7	%	%	INTJ
eurjchem-596	57	8	):	):	PUNCT
eurjchem-596	57	9	417	417	NUM
eurjchem-596	57	10	(	(	PUNCT
eurjchem-596	57	11	m+	m+	NUM
eurjchem-596	57	12	,	,	PUNCT
eurjchem-596	57	13	7.4	7.4	NUM
eurjchem-596	57	14	)	)	PUNCT
eurjchem-596	57	15	,	,	PUNCT
eurjchem-596	57	16	167	167	NUM
eurjchem-596	57	17	(	(	PUNCT
eurjchem-596	57	18	100	100	NUM
eurjchem-596	57	19	)	)	PUNCT
eurjchem-596	57	20	.	.	PUNCT
eurjchem-596	58	1	anal	anal	PROPN
eurjchem-596	58	2	.	.	PUNCT
eurjchem-596	58	3	calcd	calcd	NOUN
eurjchem-596	58	4	.	.	PUNCT
eurjchem-596	59	1	for	for	ADP
eurjchem-596	59	2	c24h23n3o4	c24h23n3o4	PROPN
eurjchem-596	59	3	:	:	PUNCT
eurjchem-596	59	4	c	c	X
eurjchem-596	59	5	,	,	PUNCT
eurjchem-596	59	6	69.05	69.05	NUM
eurjchem-596	59	7	;	;	PUNCT
eurjchem-596	59	8	h	h	NOUN
eurjchem-596	59	9	,	,	PUNCT
eurjchem-596	59	10	5.55	5.55	NUM
eurjchem-596	59	11	;	;	PUNCT
eurjchem-596	59	12	n	n	CCONJ
eurjchem-596	59	13	,	,	PUNCT
eurjchem-596	59	14	10.07	10.07	NUM
eurjchem-596	59	15	.	.	PUNCT
eurjchem-596	59	16	found	find	VERB
eurjchem-596	59	17	:	:	PUNCT
eurjchem-596	60	1	c	c	X
eurjchem-596	60	2	,	,	PUNCT
eurjchem-596	60	3	69.43	69.43	NUM
eurjchem-596	60	4	;	;	PUNCT
eurjchem-596	60	5	h	h	NOUN
eurjchem-596	60	6	,	,	PUNCT
eurjchem-596	60	7	5.45	5.45	NUM
eurjchem-596	60	8	;	;	PUNCT
eurjchem-596	60	9	n	n	CCONJ
eurjchem-596	60	10	,	,	PUNCT
eurjchem-596	60	11	10.34	10.34	NUM
eurjchem-596	60	12	%	%	NOUN
eurjchem-596	60	13	.	.	PUNCT
eurjchem-596	61	1	ethyl	ethyl	PROPN
eurjchem-596	61	2	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(3‐nitro	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(3‐nitro	PROPN
eurjchem-596	61	3	phenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	phenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	NOUN
eurjchem-596	61	4	(	(	PUNCT
eurjchem-596	61	5	4c	4c	NOUN
eurjchem-596	61	6	):	):	PUNCT
eurjchem-596	61	7	yield	yield	NOUN
eurjchem-596	61	8	:	:	PUNCT
eurjchem-596	61	9	80	80	NUM
eurjchem-596	61	10	%	%	NOUN
eurjchem-596	61	11	.	.	PUNCT
eurjchem-596	62	1	m.p	m.p	PROPN
eurjchem-596	62	2	.	.	PROPN
eurjchem-596	62	3	:	:	PUNCT
eurjchem-596	62	4	145‐147	145‐147	PROPN
eurjchem-596	62	5	c	c	ADJ
eurjchem-596	62	6	.	.	PUNCT
eurjchem-596	63	1	ir	ir	PROPN
eurjchem-596	63	2	(	(	PUNCT
eurjchem-596	63	3	kbr	kbr	PROPN
eurjchem-596	63	4	,	,	PUNCT
eurjchem-596	63	5	ν	ν	PROPN
eurjchem-596	63	6	,	,	PUNCT
eurjchem-596	63	7	cm–1	cm–1	PROPN
eurjchem-596	63	8	):	):	PUNCT
eurjchem-596	63	9	3227	3227	NUM
eurjchem-596	63	10	,	,	PUNCT
eurjchem-596	63	11	3209	3209	NUM
eurjchem-596	63	12	(	(	PUNCT
eurjchem-596	63	13	nh2	nh2	PROPN
eurjchem-596	63	14	)	)	PUNCT
eurjchem-596	63	15	,	,	PUNCT
eurjchem-596	63	16	3082	3082	NUM
eurjchem-596	63	17	(	(	PUNCT
eurjchem-596	63	18	ch	ch	NOUN
eurjchem-596	63	19	arom	arom	NOUN
eurjchem-596	63	20	.	.	PUNCT
eurjchem-596	63	21	)	)	PUNCT
eurjchem-596	63	22	,	,	PUNCT
eurjchem-596	63	23	2964	2964	NUM
eurjchem-596	63	24	,	,	PUNCT
eurjchem-596	63	25	2931	2931	NUM
eurjchem-596	63	26	,	,	PUNCT
eurjchem-596	63	27	2872	2872	NUM
eurjchem-596	63	28	(	(	PUNCT
eurjchem-596	63	29	ch	ch	NOUN
eurjchem-596	63	30	aliph	aliph	PROPN
eurjchem-596	63	31	.	.	PUNCT
eurjchem-596	63	32	)	)	PUNCT
eurjchem-596	63	33	,	,	PUNCT
eurjchem-596	63	34	2194	2194	NUM
eurjchem-596	63	35	(	(	PUNCT
eurjchem-596	63	36	c≡n	c≡n	PROPN
eurjchem-596	63	37	)	)	PUNCT
eurjchem-596	63	38	,	,	PUNCT
eurjchem-596	63	39	1680	1680	NUM
eurjchem-596	63	40	,	,	PUNCT
eurjchem-596	63	41	1688	1688	NUM
eurjchem-596	63	42	(	(	PUNCT
eurjchem-596	63	43	2c	2c	NOUN
eurjchem-596	63	44	=	=	SYM
eurjchem-596	63	45	o	o	NOUN
eurjchem-596	63	46	)	)	PUNCT
eurjchem-596	63	47	.	.	PUNCT
eurjchem-596	64	1	1h	1h	NUM
eurjchem-596	64	2	nmr	nmr	NOUN
eurjchem-596	64	3	(	(	PUNCT
eurjchem-596	64	4	300	300	NUM
eurjchem-596	64	5	mhz	mhz	NOUN
eurjchem-596	64	6	,	,	PUNCT
eurjchem-596	64	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	64	8	,	,	PUNCT
eurjchem-596	64	9			NUM
eurjchem-596	64	10	,	,	PUNCT
eurjchem-596	64	11	ppm	ppm	NOUN
eurjchem-596	64	12	):	):	PUNCT
eurjchem-596	64	13	1.05	1.05	NUM
eurjchem-596	64	14	(	(	PUNCT
eurjchem-596	64	15	t	t	PROPN
eurjchem-596	64	16	,	,	PUNCT
eurjchem-596	64	17	3h	3h	NUM
eurjchem-596	64	18	,	,	PUNCT
eurjchem-596	64	19	ch3	ch3	PROPN
eurjchem-596	64	20	,	,	PUNCT
eurjchem-596	64	21	j	j	PROPN
eurjchem-596	64	22	=	=	PUNCT
eurjchem-596	64	23	0.2	0.2	NUM
eurjchem-596	64	24	hz	hz	NOUN
eurjchem-596	64	25	)	)	PUNCT
eurjchem-596	64	26	,	,	PUNCT
eurjchem-596	64	27	1.3	1.3	NUM
eurjchem-596	64	28	(	(	PUNCT
eurjchem-596	64	29	t	t	PROPN
eurjchem-596	64	30	,	,	PUNCT
eurjchem-596	64	31	3h	3h	NUM
eurjchem-596	64	32	,	,	PUNCT
eurjchem-596	64	33	ch3	ch3	PROPN
eurjchem-596	64	34	,	,	PUNCT
eurjchem-596	64	35	j	j	PROPN
eurjchem-596	64	36	=	=	PROPN
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eurjchem-596	64	38	hz	hz	NOUN
eurjchem-596	64	39	)	)	PUNCT
eurjchem-596	64	40	,	,	PUNCT
eurjchem-596	64	41	2,6	2,6	NUM
eurjchem-596	64	42	(	(	PUNCT
eurjchem-596	64	43	q	q	NOUN
eurjchem-596	64	44	,	,	PUNCT
eurjchem-596	64	45	2h	2h	NUM
eurjchem-596	64	46	,	,	PUNCT
eurjchem-596	64	47	ch2	ch2	PROPN
eurjchem-596	64	48	,	,	PUNCT
eurjchem-596	64	49	j	j	PROPN
eurjchem-596	64	50	=	=	PUNCT
eurjchem-596	64	51	0.2	0.2	NUM
eurjchem-596	64	52	hz	hz	NOUN
eurjchem-596	64	53	)	)	PUNCT
eurjchem-596	64	54	,	,	PUNCT
eurjchem-596	64	55	4.3	4.3	NUM
eurjchem-596	64	56	(	(	PUNCT
eurjchem-596	64	57	q	q	NOUN
eurjchem-596	64	58	,	,	PUNCT
eurjchem-596	64	59	2h	2h	NUM
eurjchem-596	64	60	,	,	PUNCT
eurjchem-596	64	61	ch2	ch2	PROPN
eurjchem-596	64	62	,	,	PUNCT
eurjchem-596	64	63	j	j	PROPN
eurjchem-596	64	64	=	=	PROPN
eurjchem-596	64	65	0.66	0.66	NUM
eurjchem-596	64	66	hz	hz	NOUN
eurjchem-596	64	67	)	)	PUNCT
eurjchem-596	64	68	,	,	PUNCT
eurjchem-596	64	69	7.2‐7.7	7.2‐7.7	NUM
eurjchem-596	64	70	(	(	PUNCT
eurjchem-596	64	71	m	m	PROPN
eurjchem-596	64	72	,	,	PUNCT
eurjchem-596	64	73	9h	9h	NUM
eurjchem-596	64	74	,	,	PUNCT
eurjchem-596	64	75	ar‐h	ar‐h	NOUN
eurjchem-596	64	76	)	)	PUNCT
eurjchem-596	64	77	,	,	PUNCT
eurjchem-596	64	78	8.3	8.3	NUM
eurjchem-596	64	79	(	(	PUNCT
eurjchem-596	64	80	s	s	PROPN
eurjchem-596	64	81	,	,	PUNCT
eurjchem-596	64	82	2h	2h	NUM
eurjchem-596	64	83	,	,	PUNCT
eurjchem-596	64	84	nh2	nh2	PROPN
eurjchem-596	64	85	,	,	PUNCT
eurjchem-596	64	86	exchangeable	exchangeable	ADJ
eurjchem-596	64	87	with	with	ADP
eurjchem-596	64	88	d2o	d2o	NOUN
eurjchem-596	64	89	)	)	PUNCT
eurjchem-596	64	90	.	.	PUNCT
eurjchem-596	65	1	ms	ms	NOUN
eurjchem-596	65	2	(	(	PUNCT
eurjchem-596	65	3	m	m	PROPN
eurjchem-596	65	4	/	/	SYM
eurjchem-596	65	5	z	z	NOUN
eurjchem-596	65	6	,	,	PUNCT
eurjchem-596	65	7	%	%	INTJ
eurjchem-596	65	8	):	):	PUNCT
eurjchem-596	65	9	432	432	NUM
eurjchem-596	65	10	(	(	PUNCT
eurjchem-596	65	11	m+	m+	NUM
eurjchem-596	65	12	,	,	PUNCT
eurjchem-596	65	13	5.7	5.7	NUM
eurjchem-596	65	14	)	)	PUNCT
eurjchem-596	65	15	,	,	PUNCT
eurjchem-596	65	16	74	74	NUM
eurjchem-596	65	17	(	(	PUNCT
eurjchem-596	65	18	100	100	NUM
eurjchem-596	65	19	)	)	PUNCT
eurjchem-596	65	20	.	.	PUNCT
eurjchem-596	66	1	anal	anal	PROPN
eurjchem-596	66	2	.	.	PUNCT
eurjchem-596	66	3	calcd	calcd	NOUN
eurjchem-596	66	4	.	.	PUNCT
eurjchem-596	67	1	for	for	SCONJ
eurjchem-596	67	2	c23h20n4o5	c23h20n4o5	PROPN
eurjchem-596	67	3	:	:	PUNCT
eurjchem-596	67	4	c	c	X
eurjchem-596	67	5	,	,	PUNCT
eurjchem-596	67	6	63.88	63.88	NUM
eurjchem-596	67	7	;	;	PUNCT
eurjchem-596	67	8	h	h	X
eurjchem-596	67	9	,	,	PUNCT
eurjchem-596	67	10	4.66	4.66	NUM
eurjchem-596	67	11	;	;	PUNCT
eurjchem-596	67	12	n	n	CCONJ
eurjchem-596	67	13	,	,	PUNCT
eurjchem-596	67	14	12.96	12.96	NUM
eurjchem-596	67	15	.	.	PUNCT
eurjchem-596	67	16	found	find	VERB
eurjchem-596	67	17	:	:	PUNCT
eurjchem-596	68	1	c	c	X
eurjchem-596	68	2	,	,	PUNCT
eurjchem-596	68	3	63.32	63.32	NUM
eurjchem-596	68	4	;	;	PUNCT
eurjchem-596	68	5	h	h	NOUN
eurjchem-596	68	6	,	,	PUNCT
eurjchem-596	68	7	4.21	4.21	NUM
eurjchem-596	68	8	;	;	PUNCT
eurjchem-596	68	9	n	n	CCONJ
eurjchem-596	68	10	,	,	PUNCT
eurjchem-596	68	11	13.12	13.12	NUM
eurjchem-596	68	12	%	%	NOUN
eurjchem-596	68	13	.	.	PUNCT
eurjchem-596	69	1	ethyl	ethyl	PROPN
eurjchem-596	69	2	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(4‐nitro	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(4‐nitro	NUM
eurjchem-596	69	3	phenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	phenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	NOUN
eurjchem-596	69	4	(	(	PUNCT
eurjchem-596	69	5	4d	4d	NUM
eurjchem-596	69	6	):	):	PUNCT
eurjchem-596	69	7	yield	yield	NOUN
eurjchem-596	69	8	:	:	PUNCT
eurjchem-596	69	9	78	78	NUM
eurjchem-596	69	10	%	%	NOUN
eurjchem-596	69	11	.	.	PUNCT
eurjchem-596	70	1	m.p	m.p	PROPN
eurjchem-596	70	2	.	.	PROPN
eurjchem-596	70	3	:	:	PUNCT
eurjchem-596	71	1	140‐142	140‐142	NUM
eurjchem-596	71	2	c	c	ADJ
eurjchem-596	71	3	.	.	PUNCT
eurjchem-596	72	1	ir	ir	PROPN
eurjchem-596	72	2	(	(	PUNCT
eurjchem-596	72	3	kbr	kbr	PROPN
eurjchem-596	72	4	,	,	PUNCT
eurjchem-596	72	5	ν	ν	PROPN
eurjchem-596	72	6	,	,	PUNCT
eurjchem-596	72	7	cm–1	cm–1	PROPN
eurjchem-596	72	8	):	):	PUNCT
eurjchem-596	72	9	3227	3227	NUM
eurjchem-596	72	10	,	,	PUNCT
eurjchem-596	72	11	3209	3209	NUM
eurjchem-596	72	12	(	(	PUNCT
eurjchem-596	72	13	nh2	nh2	PROPN
eurjchem-596	72	14	)	)	PUNCT
eurjchem-596	72	15	,	,	PUNCT
eurjchem-596	72	16	3082	3082	NUM
eurjchem-596	72	17	(	(	PUNCT
eurjchem-596	72	18	ch	ch	NOUN
eurjchem-596	72	19	arom	arom	NOUN
eurjchem-596	72	20	.	.	PUNCT
eurjchem-596	72	21	)	)	PUNCT
eurjchem-596	72	22	,	,	PUNCT
eurjchem-596	72	23	2964	2964	NUM
eurjchem-596	72	24	,	,	PUNCT
eurjchem-596	72	25	2872	2872	NUM
eurjchem-596	72	26	(	(	PUNCT
eurjchem-596	72	27	ch	ch	NOUN
eurjchem-596	72	28	aliph	aliph	PROPN
eurjchem-596	72	29	.	.	PUNCT
eurjchem-596	72	30	)	)	PUNCT
eurjchem-596	72	31	,	,	PUNCT
eurjchem-596	72	32	2194	2194	NUM
eurjchem-596	72	33	(	(	PUNCT
eurjchem-596	72	34	c≡n	c≡n	PROPN
eurjchem-596	72	35	)	)	PUNCT
eurjchem-596	72	36	,	,	PUNCT
eurjchem-596	72	37	1680	1680	NUM
eurjchem-596	72	38	,	,	PUNCT
eurjchem-596	72	39	1690	1690	NUM
eurjchem-596	72	40	(	(	PUNCT
eurjchem-596	72	41	2c	2c	NOUN
eurjchem-596	72	42	=	=	SYM
eurjchem-596	72	43	o	o	NOUN
eurjchem-596	72	44	)	)	PUNCT
eurjchem-596	72	45	.	.	PUNCT
eurjchem-596	73	1	1h	1h	NUM
eurjchem-596	73	2	nmr	nmr	NOUN
eurjchem-596	73	3	(	(	PUNCT
eurjchem-596	73	4	300	300	NUM
eurjchem-596	73	5	mhz	mhz	NOUN
eurjchem-596	73	6	,	,	PUNCT
eurjchem-596	73	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	73	8	,	,	PUNCT
eurjchem-596	73	9			NUM
eurjchem-596	73	10	,	,	PUNCT
eurjchem-596	73	11	ppm	ppm	NOUN
eurjchem-596	73	12	):	):	PUNCT
eurjchem-596	73	13	1.05	1.05	NUM
eurjchem-596	73	14	(	(	PUNCT
eurjchem-596	73	15	t	t	PROPN
eurjchem-596	73	16	,	,	PUNCT
eurjchem-596	73	17	3h	3h	NUM
eurjchem-596	73	18	,	,	PUNCT
eurjchem-596	73	19	ch3	ch3	PROPN
eurjchem-596	73	20	,	,	PUNCT
eurjchem-596	73	21	j	j	PROPN
eurjchem-596	73	22	=	=	PUNCT
eurjchem-596	73	23	0.2	0.2	NUM
eurjchem-596	73	24	hz	hz	NOUN
eurjchem-596	73	25	)	)	PUNCT
eurjchem-596	73	26	,	,	PUNCT
eurjchem-596	73	27	1.3	1.3	NUM
eurjchem-596	73	28	(	(	PUNCT
eurjchem-596	73	29	t	t	PROPN
eurjchem-596	73	30	,	,	PUNCT
eurjchem-596	73	31	3h	3h	NUM
eurjchem-596	73	32	,	,	PUNCT
eurjchem-596	73	33	ch3	ch3	PROPN
eurjchem-596	73	34	,	,	PUNCT
eurjchem-596	73	35	j	j	PROPN
eurjchem-596	73	36	=	=	PROPN
eurjchem-596	73	37	0.66	0.66	NUM
eurjchem-596	73	38	hz	hz	NOUN
eurjchem-596	73	39	)	)	PUNCT
eurjchem-596	73	40	,	,	PUNCT
eurjchem-596	73	41	2.6	2.6	NUM
eurjchem-596	73	42	(	(	PUNCT
eurjchem-596	73	43	q	q	NOUN
eurjchem-596	73	44	,	,	PUNCT
eurjchem-596	73	45	2h	2h	NUM
eurjchem-596	73	46	,	,	PUNCT
eurjchem-596	73	47	ch2	ch2	PROPN
eurjchem-596	73	48	,	,	PUNCT
eurjchem-596	73	49	j	j	PROPN
eurjchem-596	73	50	=	=	PUNCT
eurjchem-596	73	51	0.2	0.2	NUM
eurjchem-596	73	52	hz	hz	NOUN
eurjchem-596	73	53	)	)	PUNCT
eurjchem-596	73	54	,	,	PUNCT
eurjchem-596	73	55	4.3	4.3	NUM
eurjchem-596	73	56	(	(	PUNCT
eurjchem-596	73	57	q	q	NOUN
eurjchem-596	73	58	,	,	PUNCT
eurjchem-596	73	59	2h	2h	NUM
eurjchem-596	73	60	,	,	PUNCT
eurjchem-596	73	61	ch2	ch2	PROPN
eurjchem-596	73	62	,	,	PUNCT
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eurjchem-596	73	66	hz	hz	NOUN
eurjchem-596	73	67	)	)	PUNCT
eurjchem-596	73	68	,	,	PUNCT
eurjchem-596	73	69	7.2‐7.7	7.2‐7.7	NUM
eurjchem-596	73	70	(	(	PUNCT
eurjchem-596	73	71	m	m	PROPN
eurjchem-596	73	72	,	,	PUNCT
eurjchem-596	73	73	8h	8h	NUM
eurjchem-596	73	74	,	,	PUNCT
eurjchem-596	73	75	ar‐h	ar‐h	PROPN
eurjchem-596	73	76	)	)	PUNCT
eurjchem-596	73	77	,	,	PUNCT
eurjchem-596	73	78	8.3	8.3	NUM
eurjchem-596	73	79	(	(	PUNCT
eurjchem-596	73	80	s	s	PROPN
eurjchem-596	73	81	,	,	PUNCT
eurjchem-596	73	82	2h	2h	NUM
eurjchem-596	73	83	,	,	PUNCT
eurjchem-596	73	84	nh2	nh2	PROPN
eurjchem-596	73	85	,	,	PUNCT
eurjchem-596	73	86	exchangeable	exchangeable	ADJ
eurjchem-596	73	87	with	with	ADP
eurjchem-596	73	88	d2o	d2o	NOUN
eurjchem-596	73	89	)	)	PUNCT
eurjchem-596	73	90	.	.	PUNCT
eurjchem-596	74	1	ms	ms	NOUN
eurjchem-596	74	2	(	(	PUNCT
eurjchem-596	74	3	m	m	PROPN
eurjchem-596	74	4	/	/	SYM
eurjchem-596	74	5	z	z	NOUN
eurjchem-596	74	6	,	,	PUNCT
eurjchem-596	74	7	%	%	INTJ
eurjchem-596	74	8	):	):	PUNCT
eurjchem-596	74	9	432	432	NUM
eurjchem-596	74	10	(	(	PUNCT
eurjchem-596	74	11	m+	m+	NUM
eurjchem-596	74	12	,	,	PUNCT
eurjchem-596	74	13	6.9	6.9	NUM
eurjchem-596	74	14	)	)	PUNCT
eurjchem-596	74	15	,	,	PUNCT
eurjchem-596	74	16	90	90	NUM
eurjchem-596	74	17	(	(	PUNCT
eurjchem-596	74	18	100	100	NUM
eurjchem-596	74	19	)	)	PUNCT
eurjchem-596	74	20	.	.	PUNCT
eurjchem-596	75	1	anal	anal	PROPN
eurjchem-596	75	2	.	.	PUNCT
eurjchem-596	75	3	calcd	calcd	NOUN
eurjchem-596	75	4	.	.	PUNCT
eurjchem-596	76	1	for	for	SCONJ
eurjchem-596	76	2	c23h20n4o5	c23h20n4o5	PROPN
eurjchem-596	76	3	:	:	PUNCT
eurjchem-596	76	4	c	c	X
eurjchem-596	76	5	,	,	PUNCT
eurjchem-596	76	6	63.88	63.88	NUM
eurjchem-596	76	7	;	;	PUNCT
eurjchem-596	76	8	h	h	X
eurjchem-596	76	9	,	,	PUNCT
eurjchem-596	76	10	4.66	4.66	NUM
eurjchem-596	76	11	;	;	PUNCT
eurjchem-596	76	12	n	n	CCONJ
eurjchem-596	76	13	,	,	PUNCT
eurjchem-596	76	14	12.96	12.96	NUM
eurjchem-596	76	15	.	.	PUNCT
eurjchem-596	76	16	found	find	VERB
eurjchem-596	76	17	:	:	PUNCT
eurjchem-596	77	1	c	c	X
eurjchem-596	77	2	,	,	PUNCT
eurjchem-596	77	3	63.50	63.50	NUM
eurjchem-596	77	4	;	;	PUNCT
eurjchem-596	77	5	h	h	NOUN
eurjchem-596	77	6	,	,	PUNCT
eurjchem-596	77	7	4.90	4.90	NUM
eurjchem-596	77	8	;	;	PUNCT
eurjchem-596	77	9	n	n	CCONJ
eurjchem-596	77	10	,	,	PUNCT
eurjchem-596	77	11	13.12	13.12	NUM
eurjchem-596	77	12	%	%	NOUN
eurjchem-596	77	13	.	.	PUNCT
eurjchem-596	78	1	ethyl	ethyl	PROPN
eurjchem-596	78	2	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(4‐	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(4‐	NUM
eurjchem-596	78	3	pipronyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	pipronyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	NOUN
eurjchem-596	78	4	(	(	PUNCT
eurjchem-596	78	5	4e	4e	NOUN
eurjchem-596	78	6	):	):	PUNCT
eurjchem-596	78	7	yield	yield	NOUN
eurjchem-596	78	8	:	:	PUNCT
eurjchem-596	78	9	81	81	NUM
eurjchem-596	78	10	%	%	NOUN
eurjchem-596	78	11	.	.	PUNCT
eurjchem-596	79	1	m.p	m.p	PROPN
eurjchem-596	79	2	.	.	PROPN
eurjchem-596	79	3	:	:	PUNCT
eurjchem-596	80	1	160‐162	160‐162	NUM
eurjchem-596	80	2	c	c	ADJ
eurjchem-596	80	3	.	.	PUNCT
eurjchem-596	81	1	ir	ir	PROPN
eurjchem-596	81	2	(	(	PUNCT
eurjchem-596	81	3	kbr	kbr	PROPN
eurjchem-596	81	4	,	,	PUNCT
eurjchem-596	81	5	ν	ν	PROPN
eurjchem-596	81	6	,	,	PUNCT
eurjchem-596	81	7	cm–1	cm–1	PROPN
eurjchem-596	81	8	):	):	PUNCT
eurjchem-596	81	9	3238	3238	NUM
eurjchem-596	81	10	,	,	PUNCT
eurjchem-596	81	11	3209	3209	NUM
eurjchem-596	81	12	(	(	PUNCT
eurjchem-596	81	13	nh2	nh2	PROPN
eurjchem-596	81	14	)	)	PUNCT
eurjchem-596	81	15	,	,	PUNCT
eurjchem-596	81	16	3055	3055	NUM
eurjchem-596	81	17	(	(	PUNCT
eurjchem-596	81	18	ch	ch	NOUN
eurjchem-596	81	19	arom	arom	NOUN
eurjchem-596	81	20	.	.	PUNCT
eurjchem-596	81	21	)	)	PUNCT
eurjchem-596	81	22	,	,	PUNCT
eurjchem-596	81	23	2924	2924	NUM
eurjchem-596	81	24	,	,	PUNCT
eurjchem-596	81	25	2872	2872	NUM
eurjchem-596	81	26	(	(	PUNCT
eurjchem-596	81	27	ch	ch	NOUN
eurjchem-596	81	28	aliph	aliph	PROPN
eurjchem-596	81	29	.	.	PUNCT
eurjchem-596	81	30	)	)	PUNCT
eurjchem-596	81	31	,	,	PUNCT
eurjchem-596	81	32	2234	2234	NUM
eurjchem-596	81	33	(	(	PUNCT
eurjchem-596	81	34	c≡n	c≡n	PROPN
eurjchem-596	81	35	)	)	PUNCT
eurjchem-596	81	36	,	,	PUNCT
eurjchem-596	81	37	1678	1678	NUM
eurjchem-596	81	38	,	,	PUNCT
eurjchem-596	81	39	1689	1689	NUM
eurjchem-596	81	40	(	(	PUNCT
eurjchem-596	81	41	2c	2c	NOUN
eurjchem-596	81	42	=	=	SYM
eurjchem-596	81	43	o	o	NOUN
eurjchem-596	81	44	)	)	PUNCT
eurjchem-596	81	45	.	.	PUNCT
eurjchem-596	82	1	1h	1h	NUM
eurjchem-596	82	2	nmr	nmr	NOUN
eurjchem-596	82	3	(	(	PUNCT
eurjchem-596	82	4	300	300	NUM
eurjchem-596	82	5	mhz	mhz	NOUN
eurjchem-596	82	6	,	,	PUNCT
eurjchem-596	82	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	82	8	,	,	PUNCT
eurjchem-596	82	9			NUM
eurjchem-596	82	10	,	,	PUNCT
eurjchem-596	82	11	ppm	ppm	NOUN
eurjchem-596	82	12	):	):	PUNCT
eurjchem-596	82	13	1.05	1.05	NUM
eurjchem-596	82	14	(	(	PUNCT
eurjchem-596	82	15	t	t	PROPN
eurjchem-596	82	16	,	,	PUNCT
eurjchem-596	82	17	3h	3h	NUM
eurjchem-596	82	18	,	,	PUNCT
eurjchem-596	82	19	ch3	ch3	PROPN
eurjchem-596	82	20	,	,	PUNCT
eurjchem-596	82	21	j	j	PROPN
eurjchem-596	82	22	=	=	PUNCT
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eurjchem-596	82	24	hz	hz	NOUN
eurjchem-596	82	25	)	)	PUNCT
eurjchem-596	82	26	,	,	PUNCT
eurjchem-596	82	27	1.3	1.3	NUM
eurjchem-596	82	28	(	(	PUNCT
eurjchem-596	82	29	t	t	PROPN
eurjchem-596	82	30	,	,	PUNCT
eurjchem-596	82	31	3h	3h	NUM
eurjchem-596	82	32	,	,	PUNCT
eurjchem-596	82	33	ch3	ch3	PROPN
eurjchem-596	82	34	,	,	PUNCT
eurjchem-596	82	35	j	j	PROPN
eurjchem-596	82	36	=	=	PROPN
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eurjchem-596	82	38	hz	hz	NOUN
eurjchem-596	82	39	)	)	PUNCT
eurjchem-596	82	40	,	,	PUNCT
eurjchem-596	82	41	2.6	2.6	NUM
eurjchem-596	82	42	(	(	PUNCT
eurjchem-596	82	43	q	q	NOUN
eurjchem-596	82	44	,	,	PUNCT
eurjchem-596	82	45	2h	2h	NUM
eurjchem-596	82	46	,	,	PUNCT
eurjchem-596	82	47	ch2	ch2	PROPN
eurjchem-596	82	48	,	,	PUNCT
eurjchem-596	82	49	j	j	PROPN
eurjchem-596	82	50	=	=	PUNCT
eurjchem-596	82	51	0.2	0.2	NUM
eurjchem-596	82	52	hz	hz	NOUN
eurjchem-596	82	53	)	)	PUNCT
eurjchem-596	82	54	,	,	PUNCT
eurjchem-596	82	55	4.3	4.3	NUM
eurjchem-596	82	56	(	(	PUNCT
eurjchem-596	82	57	q	q	NOUN
eurjchem-596	82	58	,	,	PUNCT
eurjchem-596	82	59	2h	2h	NUM
eurjchem-596	82	60	,	,	PUNCT
eurjchem-596	82	61	ch2	ch2	PROPN
eurjchem-596	82	62	,	,	PUNCT
eurjchem-596	82	63	j	j	PROPN
eurjchem-596	82	64	=	=	PROPN
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eurjchem-596	82	66	hz	hz	NOUN
eurjchem-596	82	67	)	)	PUNCT
eurjchem-596	82	68	,	,	PUNCT
eurjchem-596	82	69	5.9	5.9	NUM
eurjchem-596	82	70	(	(	PUNCT
eurjchem-596	82	71	s	s	PROPN
eurjchem-596	82	72	,	,	PUNCT
eurjchem-596	82	73	2h	2h	NUM
eurjchem-596	82	74	,	,	PUNCT
eurjchem-596	82	75	ch2‐piperonyl	ch2‐piperonyl	PROPN
eurjchem-596	82	76	)	)	PUNCT
eurjchem-596	82	77	,	,	PUNCT
eurjchem-596	82	78	7.2‐7.7	7.2‐7.7	NUM
eurjchem-596	82	79	(	(	PUNCT
eurjchem-596	82	80	m	m	PROPN
eurjchem-596	82	81	,	,	PUNCT
eurjchem-596	82	82	7h	7h	PROPN
eurjchem-596	82	83	,	,	PUNCT
eurjchem-596	82	84	ar‐h	ar‐h	PROPN
eurjchem-596	82	85	)	)	PUNCT
eurjchem-596	82	86	,	,	PUNCT
eurjchem-596	82	87	8.3	8.3	NUM
eurjchem-596	82	88	(	(	PUNCT
eurjchem-596	82	89	s	s	PROPN
eurjchem-596	82	90	,	,	PUNCT
eurjchem-596	82	91	2h	2h	NUM
eurjchem-596	82	92	,	,	PUNCT
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eurjchem-596	82	94	,	,	PUNCT
eurjchem-596	82	95	exchangeable	exchangeable	ADJ
eurjchem-596	82	96	with	with	ADP
eurjchem-596	82	97	d2o	d2o	NOUN
eurjchem-596	82	98	)	)	PUNCT
eurjchem-596	82	99	.	.	PUNCT
eurjchem-596	83	1	anal	anal	PROPN
eurjchem-596	83	2	.	.	PUNCT
eurjchem-596	83	3	calcd	calcd	NOUN
eurjchem-596	83	4	.	.	PUNCT
eurjchem-596	84	1	for	for	ADP
eurjchem-596	84	2	c24h21n3o5	c24h21n3o5	NUM
eurjchem-596	84	3	:	:	PUNCT
eurjchem-596	84	4	c	c	X
eurjchem-596	84	5	,	,	PUNCT
eurjchem-596	84	6	66.81	66.81	NUM
eurjchem-596	84	7	;	;	PUNCT
eurjchem-596	84	8	h	h	X
eurjchem-596	84	9	,	,	PUNCT
eurjchem-596	84	10	4.91	4.91	NUM
eurjchem-596	84	11	;	;	PUNCT
eurjchem-596	84	12	n	n	CCONJ
eurjchem-596	84	13	,	,	PUNCT
eurjchem-596	84	14	9.74	9.74	NUM
eurjchem-596	84	15	.	.	PUNCT
eurjchem-596	84	16	found	find	VERB
eurjchem-596	84	17	:	:	PUNCT
eurjchem-596	85	1	c	c	X
eurjchem-596	85	2	,	,	PUNCT
eurjchem-596	85	3	66.50	66.50	NUM
eurjchem-596	85	4	;	;	PUNCT
eurjchem-596	85	5	h	h	NOUN
eurjchem-596	85	6	,	,	PUNCT
eurjchem-596	85	7	4.90	4.90	NUM
eurjchem-596	85	8	;	;	PUNCT
eurjchem-596	85	9	n	n	CCONJ
eurjchem-596	85	10	,	,	PUNCT
eurjchem-596	85	11	9.51	9.51	NUM
eurjchem-596	85	12	%	%	NOUN
eurjchem-596	85	13	.	.	PUNCT
eurjchem-596	86	1	ethyl	ethyl	PROPN
eurjchem-596	86	2	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(3‐ethoxy‐	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(3‐ethoxy‐	PROPN
eurjchem-596	86	3	4‐methoxy)‐1,6‐dihydro‐pyridine‐3‐carboxylate	4‐methoxy)‐1,6‐dihydro‐pyridine‐3‐carboxylate	PROPN
eurjchem-596	86	4	(	(	PUNCT
eurjchem-596	86	5	4f	4f	NUM
eurjchem-596	86	6	):	):	PUNCT
eurjchem-596	86	7	yield	yield	NOUN
eurjchem-596	86	8	:	:	PUNCT
eurjchem-596	86	9	76	76	NUM
eurjchem-596	86	10	%	%	NOUN
eurjchem-596	86	11	.	.	PUNCT
eurjchem-596	87	1	m.p	m.p	PROPN
eurjchem-596	87	2	.	.	PROPN
eurjchem-596	87	3	:	:	PUNCT
eurjchem-596	87	4	167‐169	167‐169	NUM
eurjchem-596	87	5	c	c	ADJ
eurjchem-596	87	6	.	.	PUNCT
eurjchem-596	88	1	ir	ir	PROPN
eurjchem-596	88	2	(	(	PUNCT
eurjchem-596	88	3	kbr	kbr	PROPN
eurjchem-596	88	4	,	,	PUNCT
eurjchem-596	88	5	ν	ν	PROPN
eurjchem-596	88	6	,	,	PUNCT
eurjchem-596	88	7	cm–1	cm–1	PROPN
eurjchem-596	88	8	):	):	PUNCT
eurjchem-596	88	9	3223	3223	NUM
eurjchem-596	88	10	,	,	PUNCT
eurjchem-596	88	11	3209	3209	NUM
eurjchem-596	88	12	(	(	PUNCT
eurjchem-596	88	13	nh2	nh2	PROPN
eurjchem-596	88	14	)	)	PUNCT
eurjchem-596	88	15	,	,	PUNCT
eurjchem-596	88	16	3055	3055	NUM
eurjchem-596	88	17	(	(	PUNCT
eurjchem-596	88	18	ch	ch	NOUN
eurjchem-596	88	19	arom	arom	NOUN
eurjchem-596	88	20	.	.	PUNCT
eurjchem-596	88	21	)	)	PUNCT
eurjchem-596	88	22	,	,	PUNCT
eurjchem-596	88	23	2924	2924	NUM
eurjchem-596	88	24	,	,	PUNCT
eurjchem-596	88	25	2872	2872	NUM
eurjchem-596	88	26	(	(	PUNCT
eurjchem-596	88	27	ch	ch	NOUN
eurjchem-596	88	28	aliph	aliph	PROPN
eurjchem-596	88	29	.	.	PUNCT
eurjchem-596	88	30	)	)	PUNCT
eurjchem-596	88	31	,	,	PUNCT
eurjchem-596	88	32	2264	2264	NUM
eurjchem-596	88	33	(	(	PUNCT
eurjchem-596	88	34	c≡n	c≡n	NOUN
eurjchem-596	88	35	)	)	PUNCT
eurjchem-596	88	36	,	,	PUNCT
eurjchem-596	88	37	1679	1679	NUM
eurjchem-596	88	38	,	,	PUNCT
eurjchem-596	88	39	1690	1690	NUM
eurjchem-596	88	40	(	(	PUNCT
eurjchem-596	88	41	2c	2c	NOUN
eurjchem-596	88	42	=	=	SYM
eurjchem-596	88	43	o	o	NOUN
eurjchem-596	88	44	)	)	PUNCT
eurjchem-596	88	45	.	.	PUNCT
eurjchem-596	89	1	1h	1h	NUM
eurjchem-596	89	2	nmr	nmr	NOUN
eurjchem-596	89	3	(	(	PUNCT
eurjchem-596	89	4	300	300	NUM
eurjchem-596	89	5	mhz	mhz	NOUN
eurjchem-596	89	6	,	,	PUNCT
eurjchem-596	89	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	89	8	,	,	PUNCT
eurjchem-596	89	9			NUM
eurjchem-596	89	10	,	,	PUNCT
eurjchem-596	89	11	ppm	ppm	NOUN
eurjchem-596	89	12	):	):	PUNCT
eurjchem-596	89	13	1.05	1.05	NUM
eurjchem-596	89	14	(	(	PUNCT
eurjchem-596	89	15	t	t	PROPN
eurjchem-596	89	16	,	,	PUNCT
eurjchem-596	89	17	3h	3h	NUM
eurjchem-596	89	18	,	,	PUNCT
eurjchem-596	89	19	ch3	ch3	PROPN
eurjchem-596	89	20	,	,	PUNCT
eurjchem-596	89	21	j	j	PROPN
eurjchem-596	89	22	=	=	PUNCT
eurjchem-596	89	23	0.2	0.2	NUM
eurjchem-596	89	24	hz	hz	NOUN
eurjchem-596	89	25	)	)	PUNCT
eurjchem-596	89	26	,	,	PUNCT
eurjchem-596	89	27	1.3	1.3	NUM
eurjchem-596	89	28	(	(	PUNCT
eurjchem-596	89	29	t	t	PROPN
eurjchem-596	89	30	,	,	PUNCT
eurjchem-596	89	31	6h	6h	NUM
eurjchem-596	89	32	,	,	PUNCT
eurjchem-596	89	33	2ch3	2ch3	NUM
eurjchem-596	89	34	,	,	PUNCT
eurjchem-596	89	35	j	j	PROPN
eurjchem-596	89	36	=	=	PROPN
eurjchem-596	89	37	0.66	0.66	NUM
eurjchem-596	89	38	hz	hz	NOUN
eurjchem-596	89	39	)	)	PUNCT
eurjchem-596	89	40	,	,	PUNCT
eurjchem-596	89	41	2.6	2.6	NUM
eurjchem-596	89	42	(	(	PUNCT
eurjchem-596	89	43	q	q	NOUN
eurjchem-596	89	44	,	,	PUNCT
eurjchem-596	89	45	2h	2h	NUM
eurjchem-596	89	46	,	,	PUNCT
eurjchem-596	89	47	ch2	ch2	PROPN
eurjchem-596	89	48	,	,	PUNCT
eurjchem-596	89	49	j	j	PROPN
eurjchem-596	89	50	=	=	PUNCT
eurjchem-596	89	51	0.2	0.2	NUM
eurjchem-596	89	52	hz	hz	NOUN
eurjchem-596	89	53	)	)	PUNCT
eurjchem-596	89	54	,	,	PUNCT
eurjchem-596	89	55	3.5	3.5	NUM
eurjchem-596	89	56	(	(	PUNCT
eurjchem-596	89	57	s	s	PROPN
eurjchem-596	89	58	,	,	PUNCT
eurjchem-596	89	59	3h	3h	NUM
eurjchem-596	89	60	,	,	PUNCT
eurjchem-596	89	61	och3	och3	ADJ
eurjchem-596	89	62	)	)	PUNCT
eurjchem-596	89	63	,	,	PUNCT
eurjchem-596	89	64	4.5	4.5	NUM
eurjchem-596	89	65	(	(	PUNCT
eurjchem-596	89	66	q	q	NOUN
eurjchem-596	89	67	,	,	PUNCT
eurjchem-596	89	68	4h	4h	NUM
eurjchem-596	89	69	,	,	PUNCT
eurjchem-596	89	70	2ch2	2ch2	NUM
eurjchem-596	89	71	,	,	PUNCT
eurjchem-596	89	72	j	j	PROPN
eurjchem-596	89	73	=	=	PROPN
eurjchem-596	89	74	0.66	0.66	NUM
eurjchem-596	89	75	hz	hz	NOUN
eurjchem-596	89	76	)	)	PUNCT
eurjchem-596	89	77	,	,	PUNCT
eurjchem-596	89	78	7.2‐7.7	7.2‐7.7	NUM
eurjchem-596	89	79	(	(	PUNCT
eurjchem-596	89	80	m	m	PROPN
eurjchem-596	89	81	,	,	PUNCT
eurjchem-596	89	82	7h	7h	PROPN
eurjchem-596	89	83	,	,	PUNCT
eurjchem-596	89	84	ar‐h	ar‐h	PROPN
eurjchem-596	89	85	)	)	PUNCT
eurjchem-596	89	86	,	,	PUNCT
eurjchem-596	89	87	8.3	8.3	NUM
eurjchem-596	89	88	(	(	PUNCT
eurjchem-596	89	89	s	s	PROPN
eurjchem-596	89	90	,	,	PUNCT
eurjchem-596	89	91	2h	2h	NUM
eurjchem-596	89	92	,	,	PUNCT
eurjchem-596	89	93	nh2	nh2	PROPN
eurjchem-596	89	94	,	,	PUNCT
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eurjchem-596	89	96	with	with	ADP
eurjchem-596	89	97	d2o	d2o	NOUN
eurjchem-596	89	98	)	)	PUNCT
eurjchem-596	89	99	.	.	PUNCT
eurjchem-596	90	1	ms	ms	NOUN
eurjchem-596	90	2	(	(	PUNCT
eurjchem-596	90	3	m	m	PROPN
eurjchem-596	90	4	/	/	SYM
eurjchem-596	90	5	z	z	NOUN
eurjchem-596	90	6	,	,	PUNCT
eurjchem-596	90	7	%	%	INTJ
eurjchem-596	90	8	):	):	PUNCT
eurjchem-596	90	9	461	461	NUM
eurjchem-596	90	10	(	(	PUNCT
eurjchem-596	90	11	m+	m+	NUM
eurjchem-596	90	12	,	,	PUNCT
eurjchem-596	90	13	10.5	10.5	NUM
eurjchem-596	90	14	)	)	PUNCT
eurjchem-596	90	15	,	,	PUNCT
eurjchem-596	90	16	167	167	NUM
eurjchem-596	90	17	(	(	PUNCT
eurjchem-596	90	18	100	100	NUM
eurjchem-596	90	19	)	)	PUNCT
eurjchem-596	90	20	.	.	PUNCT
eurjchem-596	91	1	anal	anal	PROPN
eurjchem-596	91	2	.	.	PUNCT
eurjchem-596	91	3	calcd	calcd	NOUN
eurjchem-596	91	4	.	.	PUNCT
eurjchem-596	92	1	for	for	ADP
eurjchem-596	92	2	c26h27n3o5	c26h27n3o5	PROPN
eurjchem-596	92	3	:	:	PUNCT
eurjchem-596	92	4	c	c	X
eurjchem-596	92	5	,	,	PUNCT
eurjchem-596	92	6	67.66	67.66	NUM
eurjchem-596	92	7	;	;	PUNCT
eurjchem-596	92	8	h	h	NOUN
eurjchem-596	92	9	,	,	PUNCT
eurjchem-596	92	10	5.90	5.90	NUM
eurjchem-596	92	11	;	;	PUNCT
eurjchem-596	92	12	n	n	CCONJ
eurjchem-596	92	13	,	,	PUNCT
eurjchem-596	92	14	9.10	9.10	NUM
eurjchem-596	92	15	.	.	PUNCT
eurjchem-596	92	16	found	find	VERB
eurjchem-596	92	17	:	:	PUNCT
eurjchem-596	93	1	c	c	X
eurjchem-596	93	2	,	,	PUNCT
eurjchem-596	93	3	67.32	67.32	NUM
eurjchem-596	93	4	;	;	PUNCT
eurjchem-596	93	5	h	h	NOUN
eurjchem-596	93	6	,	,	PUNCT
eurjchem-596	93	7	5.71	5.71	NUM
eurjchem-596	93	8	;	;	PUNCT
eurjchem-596	93	9	n	n	CCONJ
eurjchem-596	93	10	,	,	PUNCT
eurjchem-596	93	11	9.42	9.42	NUM
eurjchem-596	93	12	%	%	NOUN
eurjchem-596	93	13	.	.	PUNCT
eurjchem-596	94	1	ethyl	ethyl	PROPN
eurjchem-596	94	2	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(2,3,4‐	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(2,3,4‐	NUM
eurjchem-596	94	3	trimethoxyphenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	trimethoxyphenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	NOUN
eurjchem-596	94	4	(	(	PUNCT
eurjchem-596	94	5	4	4	NUM
eurjchem-596	94	6	g	g	NOUN
eurjchem-596	94	7	):	):	PUNCT
eurjchem-596	94	8	yield	yield	NOUN
eurjchem-596	94	9	:	:	PUNCT
eurjchem-596	94	10	87	87	NUM
eurjchem-596	94	11	%	%	NOUN
eurjchem-596	94	12	.	.	PUNCT
eurjchem-596	95	1	m.p	m.p	PROPN
eurjchem-596	95	2	.	.	PROPN
eurjchem-596	95	3	:	:	PUNCT
eurjchem-596	96	1	189‐190	189‐190	NUM
eurjchem-596	96	2	c	c	ADJ
eurjchem-596	96	3	.	.	PUNCT
eurjchem-596	97	1	ir	ir	PROPN
eurjchem-596	97	2	(	(	PUNCT
eurjchem-596	97	3	kbr	kbr	PROPN
eurjchem-596	97	4	,	,	PUNCT
eurjchem-596	97	5	ν	ν	PROPN
eurjchem-596	97	6	,	,	PUNCT
eurjchem-596	97	7	cm–1	cm–1	PROPN
eurjchem-596	97	8	):	):	PUNCT
eurjchem-596	97	9	3223	3223	NUM
eurjchem-596	97	10	,	,	PUNCT
eurjchem-596	97	11	3209	3209	NUM
eurjchem-596	97	12	(	(	PUNCT
eurjchem-596	97	13	nh2	nh2	PROPN
eurjchem-596	97	14	)	)	PUNCT
eurjchem-596	97	15	,	,	PUNCT
eurjchem-596	97	16	3055	3055	NUM
eurjchem-596	97	17	(	(	PUNCT
eurjchem-596	97	18	ch	ch	NOUN
eurjchem-596	97	19	arom	arom	NOUN
eurjchem-596	97	20	.	.	PUNCT
eurjchem-596	97	21	)	)	PUNCT
eurjchem-596	97	22	,	,	PUNCT
eurjchem-596	97	23	2924	2924	NUM
eurjchem-596	97	24	,	,	PUNCT
eurjchem-596	97	25	2872	2872	NUM
eurjchem-596	97	26	(	(	PUNCT
eurjchem-596	97	27	ch	ch	NOUN
eurjchem-596	97	28	aliph	aliph	PROPN
eurjchem-596	97	29	.	.	PUNCT
eurjchem-596	97	30	)	)	PUNCT
eurjchem-596	97	31	,	,	PUNCT
eurjchem-596	97	32	2264	2264	NUM
eurjchem-596	97	33	(	(	PUNCT
eurjchem-596	97	34	c≡n	c≡n	NOUN
eurjchem-596	97	35	)	)	PUNCT
eurjchem-596	97	36	,	,	PUNCT
eurjchem-596	97	37	1679	1679	NUM
eurjchem-596	97	38	,	,	PUNCT
eurjchem-596	97	39	1687	1687	NUM
eurjchem-596	97	40	(	(	PUNCT
eurjchem-596	97	41	2c	2c	NOUN
eurjchem-596	97	42	=	=	SYM
eurjchem-596	97	43	o	o	NOUN
eurjchem-596	97	44	)	)	PUNCT
eurjchem-596	97	45	.	.	PUNCT
eurjchem-596	98	1	1h	1h	NUM
eurjchem-596	98	2	nmr	nmr	NOUN
eurjchem-596	98	3	(	(	PUNCT
eurjchem-596	98	4	300	300	NUM
eurjchem-596	98	5	mhz	mhz	NOUN
eurjchem-596	98	6	,	,	PUNCT
eurjchem-596	98	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	98	8	,	,	PUNCT
eurjchem-596	98	9			NUM
eurjchem-596	98	10	,	,	PUNCT
eurjchem-596	98	11	ppm	ppm	NOUN
eurjchem-596	98	12	):	):	PUNCT
eurjchem-596	98	13	1.05	1.05	NUM
eurjchem-596	98	14	(	(	PUNCT
eurjchem-596	98	15	t	t	PROPN
eurjchem-596	98	16	,	,	PUNCT
eurjchem-596	98	17	3h	3h	NUM
eurjchem-596	98	18	,	,	PUNCT
eurjchem-596	98	19	ch3	ch3	PROPN
eurjchem-596	98	20	,	,	PUNCT
eurjchem-596	98	21	j	j	PROPN
eurjchem-596	98	22	=	=	PUNCT
eurjchem-596	98	23	0.2	0.2	NUM
eurjchem-596	98	24	hz	hz	NOUN
eurjchem-596	98	25	)	)	PUNCT
eurjchem-596	98	26	,	,	PUNCT
eurjchem-596	98	27	1.3	1.3	NUM
eurjchem-596	98	28	(	(	PUNCT
eurjchem-596	98	29	t	t	PROPN
eurjchem-596	98	30	,	,	PUNCT
eurjchem-596	98	31	3h	3h	NUM
eurjchem-596	98	32	,	,	PUNCT
eurjchem-596	98	33	ch3	ch3	PROPN
eurjchem-596	98	34	,	,	PUNCT
eurjchem-596	98	35	j	j	PROPN
eurjchem-596	98	36	=	=	PROPN
eurjchem-596	98	37	0.66	0.66	NUM
eurjchem-596	98	38	hz	hz	NOUN
eurjchem-596	98	39	)	)	PUNCT
eurjchem-596	98	40	,	,	PUNCT
eurjchem-596	98	41	2.6	2.6	NUM
eurjchem-596	98	42	(	(	PUNCT
eurjchem-596	98	43	q	q	NOUN
eurjchem-596	98	44	,	,	PUNCT
eurjchem-596	98	45	2h	2h	NUM
eurjchem-596	98	46	,	,	PUNCT
eurjchem-596	98	47	ch2	ch2	PROPN
eurjchem-596	98	48	,	,	PUNCT
eurjchem-596	98	49	j	j	PROPN
eurjchem-596	98	50	=	=	PUNCT
eurjchem-596	98	51	0.2	0.2	NUM
eurjchem-596	98	52	hz	hz	NOUN
eurjchem-596	98	53	)	)	PUNCT
eurjchem-596	98	54	,	,	PUNCT
eurjchem-596	98	55	3.8	3.8	NUM
eurjchem-596	98	56	(	(	PUNCT
eurjchem-596	98	57	s	s	PROPN
eurjchem-596	98	58	,	,	PUNCT
eurjchem-596	98	59	9h	9h	NUM
eurjchem-596	98	60	,	,	PUNCT
eurjchem-596	98	61	3och3	3och3	NUM
eurjchem-596	98	62	)	)	PUNCT
eurjchem-596	98	63	,	,	PUNCT
eurjchem-596	98	64	4.5	4.5	NUM
eurjchem-596	98	65	(	(	PUNCT
eurjchem-596	98	66	q	q	NOUN
eurjchem-596	98	67	,	,	PUNCT
eurjchem-596	98	68	4h	4h	NUM
eurjchem-596	98	69	,	,	PUNCT
eurjchem-596	98	70	2ch2	2ch2	NUM
eurjchem-596	98	71	,	,	PUNCT
eurjchem-596	98	72	j	j	PROPN
eurjchem-596	98	73	=	=	PROPN
eurjchem-596	98	74	0.66	0.66	NUM
eurjchem-596	98	75	hz	hz	NOUN
eurjchem-596	98	76	)	)	PUNCT
eurjchem-596	98	77	,	,	PUNCT
eurjchem-596	98	78	7.2‐7.7	7.2‐7.7	NUM
eurjchem-596	98	79	(	(	PUNCT
eurjchem-596	98	80	m	m	PROPN
eurjchem-596	98	81	,	,	PUNCT
eurjchem-596	98	82	6h	6h	NUM
eurjchem-596	98	83	,	,	PUNCT
eurjchem-596	98	84	ar‐h	ar‐h	PROPN
eurjchem-596	98	85	)	)	PUNCT
eurjchem-596	98	86	,	,	PUNCT
eurjchem-596	98	87	8.3	8.3	NUM
eurjchem-596	98	88	(	(	PUNCT
eurjchem-596	98	89	s	s	PROPN
eurjchem-596	98	90	,	,	PUNCT
eurjchem-596	98	91	2h	2h	NUM
eurjchem-596	98	92	,	,	PUNCT
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eurjchem-596	98	94	,	,	PUNCT
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eurjchem-596	98	97	d2o	d2o	NOUN
eurjchem-596	98	98	)	)	PUNCT
eurjchem-596	98	99	.	.	PUNCT
eurjchem-596	99	1	ms	ms	NOUN
eurjchem-596	99	2	(	(	PUNCT
eurjchem-596	99	3	m	m	PROPN
eurjchem-596	99	4	/	/	SYM
eurjchem-596	99	5	z	z	NOUN
eurjchem-596	99	6	,	,	PUNCT
eurjchem-596	99	7	%	%	INTJ
eurjchem-596	99	8	):	):	PUNCT
eurjchem-596	99	9	573	573	NUM
eurjchem-596	99	10	(	(	PUNCT
eurjchem-596	99	11	m+	m+	NUM
eurjchem-596	99	12	,	,	PUNCT
eurjchem-596	99	13	21	21	NUM
eurjchem-596	99	14	)	)	PUNCT
eurjchem-596	99	15	,	,	PUNCT
eurjchem-596	99	16	90	90	NUM
eurjchem-596	99	17	(	(	PUNCT
eurjchem-596	99	18	100	100	NUM
eurjchem-596	99	19	)	)	PUNCT
eurjchem-596	99	20	.	.	PUNCT
eurjchem-596	100	1	anal	anal	PROPN
eurjchem-596	100	2	.	.	PUNCT
eurjchem-596	100	3	calcd	calcd	NOUN
eurjchem-596	100	4	.	.	PUNCT
eurjchem-596	101	1	for	for	ADP
eurjchem-596	101	2	c26h27n3o6	c26h27n3o6	NOUN
eurjchem-596	101	3	:	:	PUNCT
eurjchem-596	101	4	c	c	X
eurjchem-596	101	5	,	,	PUNCT
eurjchem-596	101	6	65.40	65.40	NUM
eurjchem-596	101	7	;	;	PUNCT
eurjchem-596	101	8	h	h	NOUN
eurjchem-596	101	9	,	,	PUNCT
eurjchem-596	101	10	5.70	5.70	NUM
eurjchem-596	101	11	;	;	PUNCT
eurjchem-596	101	12	n	n	CCONJ
eurjchem-596	101	13	,	,	PUNCT
eurjchem-596	101	14	8.80	8.80	NUM
eurjchem-596	101	15	.	.	PUNCT
eurjchem-596	101	16	found	find	VERB
eurjchem-596	101	17	:	:	PUNCT
eurjchem-596	102	1	c	c	X
eurjchem-596	102	2	,	,	PUNCT
eurjchem-596	102	3	65.32	65.32	NUM
eurjchem-596	102	4	;	;	PUNCT
eurjchem-596	102	5	h	h	NOUN
eurjchem-596	102	6	,	,	PUNCT
eurjchem-596	102	7	5.50	5.50	NUM
eurjchem-596	102	8	;	;	PUNCT
eurjchem-596	102	9	n	n	CCONJ
eurjchem-596	102	10	,	,	PUNCT
eurjchem-596	102	11	8.65	8.65	NUM
eurjchem-596	102	12	%	%	NOUN
eurjchem-596	102	13	.	.	PUNCT
eurjchem-596	103	1	ethyl	ethyl	PROPN
eurjchem-596	103	2	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(2‐chloro	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(2‐chloro	NUM
eurjchem-596	103	3	phenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	phenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	NOUN
eurjchem-596	103	4	(	(	PUNCT
eurjchem-596	103	5	4h	4h	NOUN
eurjchem-596	103	6	):	):	PUNCT
eurjchem-596	103	7	yield	yield	NOUN
eurjchem-596	103	8	:	:	PUNCT
eurjchem-596	103	9	90	90	NUM
eurjchem-596	103	10	%	%	NOUN
eurjchem-596	103	11	.	.	PUNCT
eurjchem-596	104	1	m.p	m.p	PROPN
eurjchem-596	104	2	.	.	PROPN
eurjchem-596	104	3	:	:	PUNCT
eurjchem-596	105	1	200‐201	200‐201	NUM
eurjchem-596	105	2	c	c	NUM
eurjchem-596	105	3	.	.	PUNCT
eurjchem-596	106	1	ir	ir	PROPN
eurjchem-596	106	2	(	(	PUNCT
eurjchem-596	106	3	kbr	kbr	PROPN
eurjchem-596	106	4	,	,	PUNCT
eurjchem-596	106	5	ν	ν	PROPN
eurjchem-596	106	6	,	,	PUNCT
eurjchem-596	106	7	cm–1	cm–1	PROPN
eurjchem-596	106	8	):	):	PUNCT
eurjchem-596	106	9	3293	3293	NUM
eurjchem-596	106	10	,	,	PUNCT
eurjchem-596	106	11	3212	3212	NUM
eurjchem-596	106	12	(	(	PUNCT
eurjchem-596	106	13	nh2	nh2	PROPN
eurjchem-596	106	14	)	)	PUNCT
eurjchem-596	106	15	,	,	PUNCT
eurjchem-596	106	16	3085	3085	NUM
eurjchem-596	106	17	(	(	PUNCT
eurjchem-596	106	18	ch	ch	NOUN
eurjchem-596	106	19	arom	arom	NOUN
eurjchem-596	106	20	.	.	PUNCT
eurjchem-596	106	21	)	)	PUNCT
eurjchem-596	106	22	,	,	PUNCT
eurjchem-596	106	23	2935	2935	NUM
eurjchem-596	106	24	,	,	PUNCT
eurjchem-596	106	25	2872	2872	NUM
eurjchem-596	106	26	(	(	PUNCT
eurjchem-596	106	27	ch	ch	NOUN
eurjchem-596	106	28	aliph	aliph	PROPN
eurjchem-596	106	29	.	.	PUNCT
eurjchem-596	106	30	)	)	PUNCT
eurjchem-596	106	31	,	,	PUNCT
eurjchem-596	106	32	2234	2234	NUM
eurjchem-596	106	33	(	(	PUNCT
eurjchem-596	106	34	c≡n	c≡n	PROPN
eurjchem-596	106	35	)	)	PUNCT
eurjchem-596	106	36	,	,	PUNCT
eurjchem-596	106	37	1660	1660	NUM
eurjchem-596	106	38	,	,	PUNCT
eurjchem-596	106	39	1678	1678	NUM
eurjchem-596	106	40	(	(	PUNCT
eurjchem-596	106	41	2c	2c	NOUN
eurjchem-596	106	42	=	=	SYM
eurjchem-596	106	43	o	o	NOUN
eurjchem-596	106	44	)	)	PUNCT
eurjchem-596	106	45	.	.	PUNCT
eurjchem-596	107	1	1h	1h	NUM
eurjchem-596	107	2	nmr	nmr	NOUN
eurjchem-596	107	3	(	(	PUNCT
eurjchem-596	107	4	300	300	NUM
eurjchem-596	107	5	mhz	mhz	NOUN
eurjchem-596	107	6	,	,	PUNCT
eurjchem-596	107	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	107	8	,	,	PUNCT
eurjchem-596	107	9			NUM
eurjchem-596	107	10	,	,	PUNCT
eurjchem-596	107	11	ppm	ppm	NOUN
eurjchem-596	107	12	):	):	PUNCT
eurjchem-596	107	13	1.05	1.05	NUM
eurjchem-596	107	14	(	(	PUNCT
eurjchem-596	107	15	t	t	PROPN
eurjchem-596	107	16	,	,	PUNCT
eurjchem-596	107	17	3h	3h	NUM
eurjchem-596	107	18	,	,	PUNCT
eurjchem-596	107	19	ch3	ch3	PROPN
eurjchem-596	107	20	,	,	PUNCT
eurjchem-596	107	21	j	j	PROPN
eurjchem-596	107	22	=	=	PUNCT
eurjchem-596	107	23	0.2	0.2	NUM
eurjchem-596	107	24	hz	hz	NOUN
eurjchem-596	107	25	)	)	PUNCT
eurjchem-596	107	26	,	,	PUNCT
eurjchem-596	107	27	1.3	1.3	NUM
eurjchem-596	107	28	(	(	PUNCT
eurjchem-596	107	29	t	t	PROPN
eurjchem-596	107	30	,	,	PUNCT
eurjchem-596	107	31	3h	3h	NUM
eurjchem-596	107	32	,	,	PUNCT
eurjchem-596	107	33	ch3	ch3	PROPN
eurjchem-596	107	34	,	,	PUNCT
eurjchem-596	107	35	j	j	PROPN
eurjchem-596	107	36	=	=	PROPN
eurjchem-596	107	37	0.66	0.66	NUM
eurjchem-596	107	38	hz	hz	NOUN
eurjchem-596	107	39	)	)	PUNCT
eurjchem-596	107	40	,	,	PUNCT
eurjchem-596	107	41	2.6	2.6	NUM
eurjchem-596	107	42	(	(	PUNCT
eurjchem-596	107	43	q	q	NOUN
eurjchem-596	107	44	,	,	PUNCT
eurjchem-596	107	45	2h	2h	NUM
eurjchem-596	107	46	,	,	PUNCT
eurjchem-596	107	47	ch2	ch2	PROPN
eurjchem-596	107	48	,	,	PUNCT
eurjchem-596	107	49	j	j	PROPN
eurjchem-596	107	50	=	=	PUNCT
eurjchem-596	107	51	0.2	0.2	NUM
eurjchem-596	107	52	hz	hz	NOUN
eurjchem-596	107	53	)	)	PUNCT
eurjchem-596	107	54	,	,	PUNCT
eurjchem-596	107	55	4.5	4.5	NUM
eurjchem-596	107	56	(	(	PUNCT
eurjchem-596	107	57	q	q	NOUN
eurjchem-596	107	58	,	,	PUNCT
eurjchem-596	107	59	2h	2h	NUM
eurjchem-596	107	60	,	,	PUNCT
eurjchem-596	107	61	2ch2	2ch2	NUM
eurjchem-596	107	62	,	,	PUNCT
eurjchem-596	107	63	j	j	PROPN
eurjchem-596	107	64	=	=	PROPN
eurjchem-596	107	65	0.66	0.66	NUM
eurjchem-596	107	66	hz	hz	NOUN
eurjchem-596	107	67	)	)	PUNCT
eurjchem-596	107	68	,	,	PUNCT
eurjchem-596	107	69	7.2‐7.7	7.2‐7.7	NUM
eurjchem-596	107	70	(	(	PUNCT
eurjchem-596	107	71	m	m	PROPN
eurjchem-596	107	72	,	,	PUNCT
eurjchem-596	107	73	8h	8h	NUM
eurjchem-596	107	74	,	,	PUNCT
eurjchem-596	107	75	ar‐h	ar‐h	PROPN
eurjchem-596	107	76	)	)	PUNCT
eurjchem-596	107	77	,	,	PUNCT
eurjchem-596	107	78	8.3	8.3	NUM
eurjchem-596	107	79	(	(	PUNCT
eurjchem-596	107	80	s	s	PROPN
eurjchem-596	107	81	,	,	PUNCT
eurjchem-596	107	82	2h	2h	NUM
eurjchem-596	107	83	,	,	PUNCT
eurjchem-596	107	84	nh2	nh2	PROPN
eurjchem-596	107	85	,	,	PUNCT
eurjchem-596	107	86	exchangeable	exchangeable	ADJ
eurjchem-596	107	87	with	with	ADP
eurjchem-596	107	88	d2o	d2o	NOUN
eurjchem-596	107	89	)	)	PUNCT
eurjchem-596	107	90	.	.	PUNCT
eurjchem-596	108	1	13c	13c	NOUN
eurjchem-596	108	2	nmr	nmr	NOUN
eurjchem-596	108	3	(	(	PUNCT
eurjchem-596	108	4	75	75	NUM
eurjchem-596	108	5	mhz	mhz	NOUN
eurjchem-596	108	6	,	,	PUNCT
eurjchem-596	108	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	108	8	,	,	PUNCT
eurjchem-596	108	9			NUM
eurjchem-596	108	10	,	,	PUNCT
eurjchem-596	108	11	ppm	ppm	ADJ
eurjchem-596	108	12	):	):	PUNCT
eurjchem-596	108	13	13.8	13.8	NUM
eurjchem-596	108	14	,	,	PUNCT
eurjchem-596	108	15	15.5	15.5	NUM
eurjchem-596	108	16	,	,	PUNCT
eurjchem-596	108	17	31.2	31.2	NUM
eurjchem-596	108	18	,	,	PUNCT
eurjchem-596	108	19	63.4	63.4	NUM
eurjchem-596	108	20	,	,	PUNCT
eurjchem-596	108	21	86.1	86.1	NUM
eurjchem-596	108	22	,	,	PUNCT
eurjchem-596	108	23	116.9	116.9	NUM
eurjchem-596	108	24	,	,	PUNCT
eurjchem-596	108	25	117.3	117.3	NUM
eurjchem-596	108	26	,	,	PUNCT
eurjchem-596	108	27	118.1	118.1	NUM
eurjchem-596	108	28	,	,	PUNCT
eurjchem-596	108	29	119.8	119.8	NUM
eurjchem-596	108	30	,	,	PUNCT
eurjchem-596	108	31	125.6	125.6	NUM
eurjchem-596	108	32	,	,	PUNCT
eurjchem-596	108	33	128.0	128.0	NUM
eurjchem-596	108	34	,	,	PUNCT
eurjchem-596	108	35	128.2	128.2	NUM
eurjchem-596	108	36	,	,	PUNCT
eurjchem-596	108	37	129.0	129.0	NUM
eurjchem-596	108	38	,	,	PUNCT
eurjchem-596	108	39	129.6	129.6	NUM
eurjchem-596	108	40	,	,	PUNCT
eurjchem-596	108	41	130.7	130.7	NUM
eurjchem-596	108	42	,	,	PUNCT
eurjchem-596	108	43	133.8	133.8	NUM
eurjchem-596	108	44	,	,	PUNCT
eurjchem-596	108	45	135.3	135.3	NUM
eurjchem-596	108	46	,	,	PUNCT
eurjchem-596	108	47	136.1	136.1	NUM
eurjchem-596	108	48	,	,	PUNCT
eurjchem-596	108	49	142.6	142.6	NUM
eurjchem-596	108	50	,	,	PUNCT
eurjchem-596	108	51	160.2	160.2	NUM
eurjchem-596	108	52	,	,	PUNCT
eurjchem-596	108	53	162.3	162.3	NUM
eurjchem-596	108	54	,	,	PUNCT
eurjchem-596	108	55	166.9	166.9	NUM
eurjchem-596	108	56	,	,	PUNCT
eurjchem-596	108	57	172.3	172.3	NUM
eurjchem-596	108	58	.	.	PUNCT
eurjchem-596	109	1	anal	anal	PROPN
eurjchem-596	109	2	.	.	PUNCT
eurjchem-596	109	3	calcd	calcd	NOUN
eurjchem-596	109	4	.	.	PUNCT
eurjchem-596	110	1	for	for	ADP
eurjchem-596	110	2	c23h20cln3o3	c23h20cln3o3	NOUN
eurjchem-596	110	3	:	:	PUNCT
eurjchem-596	110	4	c	c	X
eurjchem-596	110	5	,	,	PUNCT
eurjchem-596	110	6	65.48	65.48	NUM
eurjchem-596	110	7	;	;	PUNCT
eurjchem-596	110	8	h	h	X
eurjchem-596	110	9	,	,	PUNCT
eurjchem-596	110	10	4.78	4.78	NUM
eurjchem-596	110	11	;	;	PUNCT
eurjchem-596	110	12	n	n	CCONJ
eurjchem-596	110	13	,	,	PUNCT
eurjchem-596	110	14	9.96	9.96	NUM
eurjchem-596	110	15	.	.	PUNCT
eurjchem-596	110	16	found	find	VERB
eurjchem-596	110	17	:	:	PUNCT
eurjchem-596	111	1	c	c	X
eurjchem-596	111	2	,	,	PUNCT
eurjchem-596	111	3	65.32	65.32	NUM
eurjchem-596	111	4	;	;	PUNCT
eurjchem-596	111	5	h	h	NOUN
eurjchem-596	111	6	,	,	PUNCT
eurjchem-596	111	7	4.71	4.71	NUM
eurjchem-596	111	8	;	;	PUNCT
eurjchem-596	111	9	n	n	CCONJ
eurjchem-596	111	10	,	,	PUNCT
eurjchem-596	111	11	9.65	9.65	NUM
eurjchem-596	111	12	%	%	NOUN
eurjchem-596	111	13	.	.	PUNCT
eurjchem-596	112	1	230	230	NUM
eurjchem-596	112	2	al‐said	al‐said	PROPN
eurjchem-596	112	3	et	et	PROPN
eurjchem-596	112	4	al	al	PROPN
eurjchem-596	112	5	.	.	PUNCT
eurjchem-596	112	6	/	/	SYM
eurjchem-596	112	7	european	european	PROPN
eurjchem-596	112	8	journal	journal	PROPN
eurjchem-596	112	9	of	of	ADP
eurjchem-596	112	10	chemistry	chemistry	NOUN
eurjchem-596	112	11	3	3	NUM
eurjchem-596	112	12	(	(	PUNCT
eurjchem-596	112	13	2	2	NUM
eurjchem-596	112	14	)	)	PUNCT
eurjchem-596	112	15	(	(	PUNCT
eurjchem-596	112	16	2012	2012	NUM
eurjchem-596	112	17	)	)	PUNCT
eurjchem-596	112	18	228‐234	228‐234	PROPN
eurjchem-596	112	19	scheme	scheme	NOUN
eurjchem-596	112	20	2	2	NUM
eurjchem-596	112	21	ethyl	ethyl	PROPN
eurjchem-596	112	22	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(3‐bromo	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(3‐bromo	NUM
eurjchem-596	112	23	phenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	phenyl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	NOUN
eurjchem-596	112	24	(	(	PUNCT
eurjchem-596	112	25	4i	4i	NUM
eurjchem-596	112	26	):	):	PUNCT
eurjchem-596	112	27	yield	yield	NOUN
eurjchem-596	112	28	:	:	PUNCT
eurjchem-596	112	29	62	62	NUM
eurjchem-596	112	30	%	%	NOUN
eurjchem-596	112	31	.	.	PUNCT
eurjchem-596	113	1	m.p	m.p	PROPN
eurjchem-596	113	2	.	.	PROPN
eurjchem-596	113	3	:	:	PUNCT
eurjchem-596	113	4	96‐98	96‐98	NUM
eurjchem-596	113	5	c	c	VERB
eurjchem-596	113	6	.	.	PUNCT
eurjchem-596	114	1	ir	ir	PROPN
eurjchem-596	114	2	(	(	PUNCT
eurjchem-596	114	3	kbr	kbr	PROPN
eurjchem-596	114	4	,	,	PUNCT
eurjchem-596	114	5	ν	ν	PROPN
eurjchem-596	114	6	,	,	PUNCT
eurjchem-596	114	7	cm–1	cm–1	PROPN
eurjchem-596	114	8	):	):	PUNCT
eurjchem-596	114	9	3334	3334	NUM
eurjchem-596	114	10	,	,	PUNCT
eurjchem-596	114	11	3246	3246	NUM
eurjchem-596	114	12	(	(	PUNCT
eurjchem-596	114	13	nh2	nh2	PROPN
eurjchem-596	114	14	)	)	PUNCT
eurjchem-596	114	15	,	,	PUNCT
eurjchem-596	114	16	3086	3086	NUM
eurjchem-596	114	17	(	(	PUNCT
eurjchem-596	114	18	ch	ch	NOUN
eurjchem-596	114	19	arom	arom	NOUN
eurjchem-596	114	20	.	.	PUNCT
eurjchem-596	114	21	)	)	PUNCT
eurjchem-596	114	22	,	,	PUNCT
eurjchem-596	114	23	2981	2981	NUM
eurjchem-596	114	24	,	,	PUNCT
eurjchem-596	114	25	2829	2829	NUM
eurjchem-596	114	26	(	(	PUNCT
eurjchem-596	114	27	ch	ch	NOUN
eurjchem-596	114	28	aliph	aliph	PROPN
eurjchem-596	114	29	.	.	PUNCT
eurjchem-596	114	30	)	)	PUNCT
eurjchem-596	114	31	,	,	PUNCT
eurjchem-596	114	32	2212	2212	NUM
eurjchem-596	114	33	(	(	PUNCT
eurjchem-596	114	34	c≡n	c≡n	PROPN
eurjchem-596	114	35	)	)	PUNCT
eurjchem-596	114	36	,	,	PUNCT
eurjchem-596	114	37	1649	1649	NUM
eurjchem-596	114	38	,	,	PUNCT
eurjchem-596	114	39	1966	1966	NUM
eurjchem-596	114	40	(	(	PUNCT
eurjchem-596	114	41	2c	2c	NOUN
eurjchem-596	114	42	=	=	SYM
eurjchem-596	114	43	o	o	NOUN
eurjchem-596	114	44	)	)	PUNCT
eurjchem-596	114	45	.	.	PUNCT
eurjchem-596	115	1	1h	1h	NUM
eurjchem-596	115	2	nmr	nmr	NOUN
eurjchem-596	115	3	(	(	PUNCT
eurjchem-596	115	4	300	300	NUM
eurjchem-596	115	5	mhz	mhz	NOUN
eurjchem-596	115	6	,	,	PUNCT
eurjchem-596	115	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	115	8	,	,	PUNCT
eurjchem-596	115	9			NUM
eurjchem-596	115	10	,	,	PUNCT
eurjchem-596	115	11	ppm	ppm	NUM
eurjchem-596	115	12	):	):	PUNCT
eurjchem-596	115	13	1.2	1.2	NUM
eurjchem-596	115	14	(	(	PUNCT
eurjchem-596	115	15	t	t	PROPN
eurjchem-596	115	16	,	,	PUNCT
eurjchem-596	115	17	3h	3h	NUM
eurjchem-596	115	18	,	,	PUNCT
eurjchem-596	115	19	ch3	ch3	PROPN
eurjchem-596	115	20	,	,	PUNCT
eurjchem-596	115	21	j	j	PROPN
eurjchem-596	115	22	=	=	PROPN
eurjchem-596	115	23	0.66	0.66	NUM
eurjchem-596	115	24	hz	hz	NOUN
eurjchem-596	115	25	)	)	PUNCT
eurjchem-596	115	26	,	,	PUNCT
eurjchem-596	115	27	1.9	1.9	NUM
eurjchem-596	115	28	(	(	PUNCT
eurjchem-596	115	29	t	t	PROPN
eurjchem-596	115	30	,	,	PUNCT
eurjchem-596	115	31	3h	3h	NUM
eurjchem-596	115	32	,	,	PUNCT
eurjchem-596	115	33	ch3	ch3	PROPN
eurjchem-596	115	34	,	,	PUNCT
eurjchem-596	115	35	j	j	PROPN
eurjchem-596	115	36	=	=	PROPN
eurjchem-596	115	37	0.66	0.66	NUM
eurjchem-596	115	38	hz	hz	NOUN
eurjchem-596	115	39	)	)	PUNCT
eurjchem-596	115	40	,	,	PUNCT
eurjchem-596	115	41	2.6	2.6	NUM
eurjchem-596	115	42	(	(	PUNCT
eurjchem-596	115	43	q	q	NOUN
eurjchem-596	115	44	,	,	PUNCT
eurjchem-596	115	45	2h	2h	NUM
eurjchem-596	115	46	,	,	PUNCT
eurjchem-596	115	47	ch2	ch2	PROPN
eurjchem-596	115	48	,	,	PUNCT
eurjchem-596	115	49	j	j	PROPN
eurjchem-596	115	50	=	=	PROPN
eurjchem-596	115	51	6.66	6.66	NUM
eurjchem-596	115	52	hz	hz	NOUN
eurjchem-596	115	53	)	)	PUNCT
eurjchem-596	115	54	,	,	PUNCT
eurjchem-596	115	55	4.5	4.5	NUM
eurjchem-596	115	56	(	(	PUNCT
eurjchem-596	115	57	q	q	NOUN
eurjchem-596	115	58	,	,	PUNCT
eurjchem-596	115	59	2h	2h	NUM
eurjchem-596	115	60	,	,	PUNCT
eurjchem-596	115	61	ch2	ch2	PROPN
eurjchem-596	115	62	,	,	PUNCT
eurjchem-596	115	63	j	j	PROPN
eurjchem-596	115	64	=	=	PROPN
eurjchem-596	115	65	0.66	0.66	NUM
eurjchem-596	115	66	hz	hz	NOUN
eurjchem-596	115	67	)	)	PUNCT
eurjchem-596	115	68	,	,	PUNCT
eurjchem-596	115	69	7.1‐7.9	7.1‐7.9	NUM
eurjchem-596	115	70	(	(	PUNCT
eurjchem-596	115	71	m	m	PROPN
eurjchem-596	115	72	,	,	PUNCT
eurjchem-596	115	73	8h	8h	NUM
eurjchem-596	115	74	,	,	PUNCT
eurjchem-596	115	75	ar‐h	ar‐h	PROPN
eurjchem-596	115	76	)	)	PUNCT
eurjchem-596	115	77	,	,	PUNCT
eurjchem-596	115	78	8.6	8.6	NUM
eurjchem-596	115	79	(	(	PUNCT
eurjchem-596	115	80	s	s	PROPN
eurjchem-596	115	81	,	,	PUNCT
eurjchem-596	115	82	2h	2h	NUM
eurjchem-596	115	83	,	,	PUNCT
eurjchem-596	115	84	nh2	nh2	PROPN
eurjchem-596	115	85	,	,	PUNCT
eurjchem-596	115	86	exchangeable	exchangeable	ADJ
eurjchem-596	115	87	with	with	ADP
eurjchem-596	115	88	d2o	d2o	NOUN
eurjchem-596	115	89	)	)	PUNCT
eurjchem-596	115	90	.	.	PUNCT
eurjchem-596	116	1	ms	ms	NOUN
eurjchem-596	116	2	(	(	PUNCT
eurjchem-596	116	3	m	m	PROPN
eurjchem-596	116	4	/	/	SYM
eurjchem-596	116	5	z	z	NOUN
eurjchem-596	116	6	,	,	PUNCT
eurjchem-596	116	7	%	%	INTJ
eurjchem-596	116	8	):	):	PUNCT
eurjchem-596	116	9	466	466	NUM
eurjchem-596	116	10	(	(	PUNCT
eurjchem-596	116	11	m+	m+	NUM
eurjchem-596	116	12	,	,	PUNCT
eurjchem-596	116	13	15.8	15.8	NUM
eurjchem-596	116	14	)	)	PUNCT
eurjchem-596	116	15	,	,	PUNCT
eurjchem-596	116	16	90	90	NUM
eurjchem-596	116	17	(	(	PUNCT
eurjchem-596	116	18	100	100	NUM
eurjchem-596	116	19	)	)	PUNCT
eurjchem-596	116	20	.	.	PUNCT
eurjchem-596	117	1	anal	anal	PROPN
eurjchem-596	117	2	.	.	PUNCT
eurjchem-596	117	3	calcd	calcd	NOUN
eurjchem-596	117	4	.	.	PUNCT
eurjchem-596	118	1	for	for	SCONJ
eurjchem-596	118	2	c23h20brn3o3	c23h20brn3o3	NOUN
eurjchem-596	118	3	:	:	PUNCT
eurjchem-596	118	4	c	c	X
eurjchem-596	118	5	,	,	PUNCT
eurjchem-596	118	6	59.24	59.24	NUM
eurjchem-596	118	7	;	;	PUNCT
eurjchem-596	118	8	h	h	NOUN
eurjchem-596	118	9	,	,	PUNCT
eurjchem-596	118	10	4.32	4.32	NUM
eurjchem-596	118	11	;	;	PUNCT
eurjchem-596	118	12	n	n	CCONJ
eurjchem-596	118	13	,	,	PUNCT
eurjchem-596	118	14	9.01	9.01	NUM
eurjchem-596	118	15	.	.	PUNCT
eurjchem-596	118	16	found	find	VERB
eurjchem-596	118	17	:	:	PUNCT
eurjchem-596	119	1	c	c	X
eurjchem-596	119	2	,	,	PUNCT
eurjchem-596	119	3	59.50	59.50	NUM
eurjchem-596	119	4	;	;	PUNCT
eurjchem-596	119	5	h	h	NOUN
eurjchem-596	119	6	,	,	PUNCT
eurjchem-596	119	7	4.20	4.20	NUM
eurjchem-596	119	8	;	;	PUNCT
eurjchem-596	119	9	n	n	CCONJ
eurjchem-596	119	10	,	,	PUNCT
eurjchem-596	119	11	9.20	9.20	NUM
eurjchem-596	119	12	%	%	NOUN
eurjchem-596	119	13	.	.	PUNCT
eurjchem-596	120	1	ethyl	ethyl	PROPN
eurjchem-596	120	2	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(thiophen‐	2‐amino‐5‐cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐4‐(thiophen‐	NUM
eurjchem-596	120	3	2‐yl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	2‐yl)‐1,6‐dihydro‐pyridine‐3‐carboxylate	PROPN
eurjchem-596	120	4	(	(	PUNCT
eurjchem-596	120	5	4j	4j	NOUN
eurjchem-596	120	6	):	):	PUNCT
eurjchem-596	120	7	yield	yield	NOUN
eurjchem-596	120	8	:	:	PUNCT
eurjchem-596	120	9	71	71	NUM
eurjchem-596	120	10	%	%	NOUN
eurjchem-596	120	11	.	.	PUNCT
eurjchem-596	121	1	m.p	m.p	PROPN
eurjchem-596	121	2	.	.	PROPN
eurjchem-596	121	3	:	:	PUNCT
eurjchem-596	122	1	105‐107	105‐107	NUM
eurjchem-596	122	2	c	c	ADJ
eurjchem-596	122	3	.	.	PUNCT
eurjchem-596	123	1	ir	ir	PROPN
eurjchem-596	123	2	(	(	PUNCT
eurjchem-596	123	3	kbr	kbr	PROPN
eurjchem-596	123	4	,	,	PUNCT
eurjchem-596	123	5	ν	ν	PROPN
eurjchem-596	123	6	,	,	PUNCT
eurjchem-596	123	7	cm–1	cm–1	PROPN
eurjchem-596	123	8	):	):	PUNCT
eurjchem-596	123	9	3325	3325	NUM
eurjchem-596	123	10	,	,	PUNCT
eurjchem-596	123	11	3209	3209	NUM
eurjchem-596	123	12	(	(	PUNCT
eurjchem-596	123	13	nh2	nh2	PROPN
eurjchem-596	123	14	)	)	PUNCT
eurjchem-596	123	15	,	,	PUNCT
eurjchem-596	123	16	3100	3100	NUM
eurjchem-596	123	17	(	(	PUNCT
eurjchem-596	123	18	ch	ch	NOUN
eurjchem-596	123	19	arom	arom	NOUN
eurjchem-596	123	20	.	.	PUNCT
eurjchem-596	123	21	)	)	PUNCT
eurjchem-596	123	22	,	,	PUNCT
eurjchem-596	123	23	2931	2931	NUM
eurjchem-596	123	24	,	,	PUNCT
eurjchem-596	123	25	2872	2872	NUM
eurjchem-596	123	26	(	(	PUNCT
eurjchem-596	123	27	ch	ch	NOUN
eurjchem-596	123	28	aliph	aliph	PROPN
eurjchem-596	123	29	.	.	PUNCT
eurjchem-596	123	30	)	)	PUNCT
eurjchem-596	123	31	,	,	PUNCT
eurjchem-596	123	32	2210	2210	NUM
eurjchem-596	123	33	(	(	PUNCT
eurjchem-596	123	34	c≡n	c≡n	PROPN
eurjchem-596	123	35	)	)	PUNCT
eurjchem-596	123	36	,	,	PUNCT
eurjchem-596	123	37	1658	1658	NUM
eurjchem-596	123	38	(	(	PUNCT
eurjchem-596	123	39	c	c	NOUN
eurjchem-596	123	40	=	=	NOUN
eurjchem-596	123	41	o	o	NOUN
eurjchem-596	123	42	)	)	PUNCT
eurjchem-596	123	43	.	.	PUNCT
eurjchem-596	124	1	1h	1h	NUM
eurjchem-596	124	2	nmr	nmr	NOUN
eurjchem-596	124	3	(	(	PUNCT
eurjchem-596	124	4	300	300	NUM
eurjchem-596	124	5	mhz	mhz	NOUN
eurjchem-596	124	6	,	,	PUNCT
eurjchem-596	124	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	124	8	,	,	PUNCT
eurjchem-596	124	9			NUM
eurjchem-596	124	10	,	,	PUNCT
eurjchem-596	124	11	ppm	ppm	NUM
eurjchem-596	124	12	):	):	PUNCT
eurjchem-596	124	13	1.2	1.2	NUM
eurjchem-596	124	14	(	(	PUNCT
eurjchem-596	124	15	t	t	PROPN
eurjchem-596	124	16	,	,	PUNCT
eurjchem-596	124	17	3h	3h	NUM
eurjchem-596	124	18	,	,	PUNCT
eurjchem-596	124	19	ch3	ch3	PROPN
eurjchem-596	124	20	,	,	PUNCT
eurjchem-596	124	21	j	j	PROPN
eurjchem-596	124	22	=	=	PROPN
eurjchem-596	124	23	0.66	0.66	NUM
eurjchem-596	124	24	hz	hz	NOUN
eurjchem-596	124	25	)	)	PUNCT
eurjchem-596	124	26	,	,	PUNCT
eurjchem-596	124	27	1.7	1.7	NUM
eurjchem-596	124	28	(	(	PUNCT
eurjchem-596	124	29	t	t	PROPN
eurjchem-596	124	30	,	,	PUNCT
eurjchem-596	124	31	3h	3h	NUM
eurjchem-596	124	32	,	,	PUNCT
eurjchem-596	124	33	ch3	ch3	PROPN
eurjchem-596	124	34	,	,	PUNCT
eurjchem-596	124	35	j	j	PROPN
eurjchem-596	124	36	=	=	PROPN
eurjchem-596	124	37	0.66	0.66	NUM
eurjchem-596	124	38	hz	hz	NOUN
eurjchem-596	124	39	)	)	PUNCT
eurjchem-596	124	40	,	,	PUNCT
eurjchem-596	124	41	2.6	2.6	NUM
eurjchem-596	124	42	(	(	PUNCT
eurjchem-596	124	43	q	q	NOUN
eurjchem-596	124	44	,	,	PUNCT
eurjchem-596	124	45	2h	2h	NUM
eurjchem-596	124	46	,	,	PUNCT
eurjchem-596	124	47	ch2	ch2	PROPN
eurjchem-596	124	48	,	,	PUNCT
eurjchem-596	124	49	j	j	PROPN
eurjchem-596	124	50	=	=	PROPN
eurjchem-596	124	51	6.66	6.66	NUM
eurjchem-596	124	52	hz	hz	NOUN
eurjchem-596	124	53	)	)	PUNCT
eurjchem-596	124	54	,	,	PUNCT
eurjchem-596	124	55	4.7	4.7	NUM
eurjchem-596	124	56	(	(	PUNCT
eurjchem-596	124	57	q	q	NOUN
eurjchem-596	124	58	,	,	PUNCT
eurjchem-596	124	59	2h	2h	NUM
eurjchem-596	124	60	,	,	PUNCT
eurjchem-596	124	61	ch2	ch2	PROPN
eurjchem-596	124	62	,	,	PUNCT
eurjchem-596	124	63	j	j	PROPN
eurjchem-596	124	64	=	=	PROPN
eurjchem-596	124	65	0.66	0.66	NUM
eurjchem-596	124	66	hz	hz	NOUN
eurjchem-596	124	67	)	)	PUNCT
eurjchem-596	124	68	,	,	PUNCT
eurjchem-596	124	69	7.2‐7.7	7.2‐7.7	NUM
eurjchem-596	124	70	(	(	PUNCT
eurjchem-596	124	71	m	m	PROPN
eurjchem-596	124	72	,	,	PUNCT
eurjchem-596	124	73	4h	4h	NUM
eurjchem-596	124	74	,	,	PUNCT
eurjchem-596	124	75	ar‐h	ar‐h	PROPN
eurjchem-596	124	76	)	)	PUNCT
eurjchem-596	124	77	,	,	PUNCT
eurjchem-596	124	78	7.5‐8.4	7.5‐8.4	NUM
eurjchem-596	124	79	(	(	PUNCT
eurjchem-596	124	80	m	m	PROPN
eurjchem-596	124	81	,	,	PUNCT
eurjchem-596	124	82	3h	3h	NUM
eurjchem-596	124	83	,	,	PUNCT
eurjchem-596	124	84	3ch	3ch	ADJ
eurjchem-596	124	85	thiophene	thiophene	NOUN
eurjchem-596	124	86	)	)	PUNCT
eurjchem-596	124	87	,	,	PUNCT
eurjchem-596	124	88	8.7	8.7	NUM
eurjchem-596	124	89	(	(	PUNCT
eurjchem-596	124	90	s	s	PROPN
eurjchem-596	124	91	,	,	PUNCT
eurjchem-596	124	92	2h	2h	NUM
eurjchem-596	124	93	,	,	PUNCT
eurjchem-596	124	94	nh2	nh2	PROPN
eurjchem-596	124	95	,	,	PUNCT
eurjchem-596	124	96	exchangeable	exchangeable	ADJ
eurjchem-596	124	97	with	with	ADP
eurjchem-596	124	98	d2o	d2o	NOUN
eurjchem-596	124	99	)	)	PUNCT
eurjchem-596	124	100	.	.	PUNCT
eurjchem-596	125	1	anal	anal	PROPN
eurjchem-596	125	2	.	.	PUNCT
eurjchem-596	125	3	calcd	calcd	NOUN
eurjchem-596	125	4	.	.	PUNCT
eurjchem-596	126	1	for	for	ADP
eurjchem-596	126	2	c21h19n3o3s	c21h19n3o3s	NUM
eurjchem-596	126	3	:	:	PUNCT
eurjchem-596	126	4	c	c	X
eurjchem-596	126	5	,	,	PUNCT
eurjchem-596	126	6	64.10	64.10	NUM
eurjchem-596	126	7	;	;	PUNCT
eurjchem-596	126	8	h	h	X
eurjchem-596	126	9	,	,	PUNCT
eurjchem-596	126	10	4.87	4.87	NUM
eurjchem-596	126	11	;	;	PUNCT
eurjchem-596	126	12	n	n	CCONJ
eurjchem-596	126	13	,	,	PUNCT
eurjchem-596	126	14	10.68	10.68	NUM
eurjchem-596	126	15	.	.	PUNCT
eurjchem-596	126	16	found	find	VERB
eurjchem-596	126	17	:	:	PUNCT
eurjchem-596	126	18	c	c	X
eurjchem-596	126	19	,	,	PUNCT
eurjchem-596	126	20	64.50	64.50	NUM
eurjchem-596	126	21	;	;	PUNCT
eurjchem-596	127	1	h	h	NOUN
eurjchem-596	127	2	,	,	PUNCT
eurjchem-596	127	3	4.70	4.70	NUM
eurjchem-596	127	4	;	;	PUNCT
eurjchem-596	127	5	n	n	CCONJ
eurjchem-596	127	6	,	,	PUNCT
eurjchem-596	127	7	10.40	10.40	NUM
eurjchem-596	127	8	%	%	NOUN
eurjchem-596	127	9	.	.	PUNCT
eurjchem-596	128	1	2.2.3	2.2.3	NUM
eurjchem-596	128	2	.	.	X
eurjchem-596	129	1	1‐(3‐ethylphenyl)‐4,6‐dimethyl‐2‐oxo‐1,2‐dihydro	1‐(3‐ethylphenyl)‐4,6‐dimethyl‐2‐oxo‐1,2‐dihydro	NUM
eurjchem-596	129	2	pyridine‐3‐carbonitrile	pyridine‐3‐carbonitrile	NUM
eurjchem-596	129	3	(	(	PUNCT
eurjchem-596	129	4	5	5	NUM
eurjchem-596	129	5	)	)	PUNCT
eurjchem-596	129	6	equimolar	equimolar	NOUN
eurjchem-596	129	7	amounts	amount	NOUN
eurjchem-596	129	8	of	of	ADP
eurjchem-596	129	9	compound	compound	NOUN
eurjchem-596	129	10	3	3	NUM
eurjchem-596	129	11	(	(	PUNCT
eurjchem-596	129	12	1.88	1.88	NUM
eurjchem-596	129	13	g	g	NOUN
eurjchem-596	129	14	,	,	PUNCT
eurjchem-596	129	15	0.01	0.01	NUM
eurjchem-596	129	16	mol	mol	NOUN
eurjchem-596	129	17	)	)	PUNCT
eurjchem-596	129	18	and	and	CCONJ
eurjchem-596	129	19	acetylacetone	acetylacetone	NOUN
eurjchem-596	129	20	(	(	PUNCT
eurjchem-596	129	21	1.00	1.00	NUM
eurjchem-596	129	22	g	g	NOUN
eurjchem-596	129	23	,	,	PUNCT
eurjchem-596	129	24	0.01	0.01	NUM
eurjchem-596	129	25	mol	mol	NOUN
eurjchem-596	129	26	)	)	PUNCT
eurjchem-596	129	27	were	be	AUX
eurjchem-596	129	28	refluxed	refluxe	VERB
eurjchem-596	129	29	in	in	ADP
eurjchem-596	129	30	ethanol	ethanol	NOUN
eurjchem-596	129	31	(	(	PUNCT
eurjchem-596	129	32	50	50	NUM
eurjchem-596	129	33	ml	ml	NOUN
eurjchem-596	129	34	)	)	PUNCT
eurjchem-596	129	35	containing	contain	VERB
eurjchem-596	129	36	piperidine	piperidine	NOUN
eurjchem-596	129	37	(	(	PUNCT
eurjchem-596	129	38	0.5	0.5	NUM
eurjchem-596	129	39	ml	ml	NOUN
eurjchem-596	129	40	)	)	PUNCT
eurjchem-596	129	41	for	for	ADP
eurjchem-596	129	42	5	5	NUM
eurjchem-596	129	43	h.	h.	NOUN
eurjchem-596	129	44	the	the	DET
eurjchem-596	129	45	reaction	reaction	NOUN
eurjchem-596	129	46	mixture	mixture	NOUN
eurjchem-596	129	47	was	be	AUX
eurjchem-596	129	48	triturated	triturate	VERB
eurjchem-596	129	49	with	with	ADP
eurjchem-596	129	50	ethanol	ethanol	NOUN
eurjchem-596	129	51	and	and	CCONJ
eurjchem-596	129	52	the	the	DET
eurjchem-596	129	53	solid	solid	ADJ
eurjchem-596	129	54	obtained	obtain	VERB
eurjchem-596	129	55	was	be	AUX
eurjchem-596	129	56	recrystallized	recrystallize	VERB
eurjchem-596	129	57	from	from	ADP
eurjchem-596	129	58	dioxane	dioxane	NOUN
eurjchem-596	129	59	to	to	PART
eurjchem-596	129	60	give	give	VERB
eurjchem-596	129	61	compound	compound	NOUN
eurjchem-596	129	62	5	5	NUM
eurjchem-596	129	63	(	(	PUNCT
eurjchem-596	129	64	scheme	scheme	NOUN
eurjchem-596	129	65	2	2	NUM
eurjchem-596	129	66	)	)	PUNCT
eurjchem-596	129	67	.	.	PUNCT
eurjchem-596	130	1	yield	yield	NOUN
eurjchem-596	130	2	:	:	PUNCT
eurjchem-596	130	3	86	86	NUM
eurjchem-596	130	4	%	%	NOUN
eurjchem-596	130	5	.	.	PUNCT
eurjchem-596	131	1	m.p	m.p	PROPN
eurjchem-596	131	2	.	.	PROPN
eurjchem-596	131	3	:	:	PUNCT
eurjchem-596	132	1	198‐200	198‐200	NUM
eurjchem-596	132	2	c	c	ADJ
eurjchem-596	132	3	.	.	PUNCT
eurjchem-596	133	1	ir	ir	PROPN
eurjchem-596	133	2	(	(	PUNCT
eurjchem-596	133	3	kbr	kbr	PROPN
eurjchem-596	133	4	,	,	PUNCT
eurjchem-596	133	5	ν	ν	PROPN
eurjchem-596	133	6	,	,	PUNCT
eurjchem-596	133	7	cm–1	cm–1	PROPN
eurjchem-596	133	8	):	):	PUNCT
eurjchem-596	133	9	3100	3100	NUM
eurjchem-596	133	10	(	(	PUNCT
eurjchem-596	133	11	ch	ch	NOUN
eurjchem-596	133	12	arom	arom	NOUN
eurjchem-596	133	13	.	.	PUNCT
eurjchem-596	133	14	)	)	PUNCT
eurjchem-596	133	15	,	,	PUNCT
eurjchem-596	133	16	2931	2931	NUM
eurjchem-596	133	17	,	,	PUNCT
eurjchem-596	133	18	2872	2872	NUM
eurjchem-596	133	19	(	(	PUNCT
eurjchem-596	133	20	ch	ch	NOUN
eurjchem-596	133	21	aliph	aliph	PROPN
eurjchem-596	133	22	.	.	PUNCT
eurjchem-596	133	23	)	)	PUNCT
eurjchem-596	133	24	,	,	PUNCT
eurjchem-596	133	25	2210	2210	NUM
eurjchem-596	133	26	(	(	PUNCT
eurjchem-596	133	27	c≡n	c≡n	PROPN
eurjchem-596	133	28	)	)	PUNCT
eurjchem-596	133	29	,	,	PUNCT
eurjchem-596	133	30	1660	1660	NUM
eurjchem-596	133	31	(	(	PUNCT
eurjchem-596	133	32	c	c	NOUN
eurjchem-596	133	33	=	=	NOUN
eurjchem-596	133	34	o	o	NOUN
eurjchem-596	133	35	)	)	PUNCT
eurjchem-596	133	36	.	.	PUNCT
eurjchem-596	134	1	1h	1h	NUM
eurjchem-596	134	2	nmr	nmr	NOUN
eurjchem-596	134	3	(	(	PUNCT
eurjchem-596	134	4	300	300	NUM
eurjchem-596	134	5	mhz	mhz	NOUN
eurjchem-596	134	6	,	,	PUNCT
eurjchem-596	134	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	134	8	,	,	PUNCT
eurjchem-596	134	9			NUM
eurjchem-596	134	10	,	,	PUNCT
eurjchem-596	134	11	ppm	ppm	NUM
eurjchem-596	134	12	):	):	PUNCT
eurjchem-596	134	13	1.2	1.2	NUM
eurjchem-596	134	14	(	(	PUNCT
eurjchem-596	134	15	t	t	PROPN
eurjchem-596	134	16	,	,	PUNCT
eurjchem-596	134	17	3h	3h	NUM
eurjchem-596	134	18	,	,	PUNCT
eurjchem-596	134	19	ch3	ch3	PROPN
eurjchem-596	134	20	,	,	PUNCT
eurjchem-596	134	21	j	j	PROPN
eurjchem-596	134	22	=	=	PROPN
eurjchem-596	134	23	0.66	0.66	NUM
eurjchem-596	134	24	hz	hz	NOUN
eurjchem-596	134	25	)	)	PUNCT
eurjchem-596	134	26	,	,	PUNCT
eurjchem-596	134	27	1.5	1.5	NUM
eurjchem-596	134	28	(	(	PUNCT
eurjchem-596	134	29	2s	2s	NUM
eurjchem-596	134	30	,	,	PUNCT
eurjchem-596	134	31	6h	6h	NUM
eurjchem-596	134	32	,	,	PUNCT
eurjchem-596	134	33	2ch3	2ch3	NUM
eurjchem-596	134	34	)	)	PUNCT
eurjchem-596	134	35	,	,	PUNCT
eurjchem-596	134	36	2.6	2.6	NUM
eurjchem-596	134	37	(	(	PUNCT
eurjchem-596	134	38	q	q	NOUN
eurjchem-596	134	39	,	,	PUNCT
eurjchem-596	134	40	2h	2h	NUM
eurjchem-596	134	41	,	,	PUNCT
eurjchem-596	134	42	ch2	ch2	PROPN
eurjchem-596	134	43	,	,	PUNCT
eurjchem-596	134	44	j	j	PROPN
eurjchem-596	134	45	=	=	PROPN
eurjchem-596	134	46	0.66	0.66	NUM
eurjchem-596	134	47	hz	hz	NOUN
eurjchem-596	134	48	)	)	PUNCT
eurjchem-596	134	49	,	,	PUNCT
eurjchem-596	134	50	5.6	5.6	NUM
eurjchem-596	134	51	(	(	PUNCT
eurjchem-596	134	52	s	s	PROPN
eurjchem-596	134	53	,	,	PUNCT
eurjchem-596	134	54	1h	1h	NUM
eurjchem-596	134	55	,	,	PUNCT
eurjchem-596	134	56	ch‐	ch‐	NOUN
eurjchem-596	134	57	pyridine	pyridine	NOUN
eurjchem-596	134	58	)	)	PUNCT
eurjchem-596	134	59	,	,	PUNCT
eurjchem-596	134	60	7.2‐7.7	7.2‐7.7	NUM
eurjchem-596	134	61	(	(	PUNCT
eurjchem-596	134	62	m	m	PROPN
eurjchem-596	134	63	,	,	PUNCT
eurjchem-596	134	64	4h	4h	NOUN
eurjchem-596	134	65	,	,	PUNCT
eurjchem-596	134	66	ar‐h	ar‐h	PROPN
eurjchem-596	134	67	)	)	PUNCT
eurjchem-596	134	68	.	.	PUNCT
eurjchem-596	135	1	anal	anal	PROPN
eurjchem-596	135	2	.	.	PUNCT
eurjchem-596	135	3	calcd	calcd	NOUN
eurjchem-596	135	4	.	.	PUNCT
eurjchem-596	136	1	for	for	ADP
eurjchem-596	136	2	c16h16n2o	c16h16n2o	NOUN
eurjchem-596	136	3	:	:	PUNCT
eurjchem-596	136	4	c	c	X
eurjchem-596	136	5	,	,	PUNCT
eurjchem-596	136	6	76.16	76.16	NUM
eurjchem-596	136	7	;	;	PUNCT
eurjchem-596	136	8	h	h	NOUN
eurjchem-596	136	9	,	,	PUNCT
eurjchem-596	136	10	6.39	6.39	NUM
eurjchem-596	136	11	;	;	PUNCT
eurjchem-596	136	12	n	n	CCONJ
eurjchem-596	136	13	,	,	PUNCT
eurjchem-596	136	14	11.10	11.10	NUM
eurjchem-596	136	15	.	.	PUNCT
eurjchem-596	136	16	found	find	VERB
eurjchem-596	136	17	:	:	PUNCT
eurjchem-596	137	1	c	c	X
eurjchem-596	137	2	,	,	PUNCT
eurjchem-596	137	3	76.50	76.50	NUM
eurjchem-596	137	4	;	;	PUNCT
eurjchem-596	137	5	h	h	NOUN
eurjchem-596	137	6	,	,	PUNCT
eurjchem-596	137	7	6.70	6.70	NUM
eurjchem-596	137	8	;	;	PUNCT
eurjchem-596	137	9	n	n	CCONJ
eurjchem-596	137	10	,	,	PUNCT
eurjchem-596	137	11	11.40	11.40	NUM
eurjchem-596	137	12	%	%	NOUN
eurjchem-596	137	13	.	.	PUNCT
eurjchem-596	138	1	2.2.4	2.2.4	X
eurjchem-596	138	2	.	.	X
eurjchem-596	138	3	6‐substituted‐	6‐substituted‐	NUM
eurjchem-596	138	4	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐	NOUN
eurjchem-596	138	5	oxo‐	oxo‐	NUM
eurjchem-596	138	6	1,2‐dihydro‐	1,2‐dihydro‐	NUM
eurjchem-596	138	7	isoquinoline‐7‐carbonitrile	isoquinoline‐7‐carbonitrile	NOUN
eurjchem-596	138	8	(	(	PUNCT
eurjchem-596	138	9	6a‐h	6a‐h	NOUN
eurjchem-596	138	10	)	)	PUNCT
eurjchem-596	138	11	general	general	ADJ
eurjchem-596	138	12	procedure	procedure	NOUN
eurjchem-596	138	13	:	:	PUNCT
eurjchem-596	138	14	a	a	DET
eurjchem-596	138	15	mixture	mixture	NOUN
eurjchem-596	138	16	of	of	ADP
eurjchem-596	138	17	compound	compound	NOUN
eurjchem-596	138	18	5	5	NUM
eurjchem-596	138	19	(	(	PUNCT
eurjchem-596	138	20	1.5	1.5	NUM
eurjchem-596	138	21	g	g	NOUN
eurjchem-596	138	22	,	,	PUNCT
eurjchem-596	138	23	0.01	0.01	NUM
eurjchem-596	138	24	mol	mol	NOUN
eurjchem-596	138	25	)	)	PUNCT
eurjchem-596	138	26	,	,	PUNCT
eurjchem-596	138	27	benzylidine‐malononitrile	benzylidine‐malononitrile	NOUN
eurjchem-596	138	28	(	(	PUNCT
eurjchem-596	138	29	0.01	0.01	NUM
eurjchem-596	138	30	mol	mol	NOUN
eurjchem-596	138	31	)	)	PUNCT
eurjchem-596	138	32	in	in	ADP
eurjchem-596	138	33	ethanol	ethanol	NOUN
eurjchem-596	138	34	(	(	PUNCT
eurjchem-596	138	35	50	50	NUM
eurjchem-596	138	36	ml	ml	NOUN
eurjchem-596	138	37	)	)	PUNCT
eurjchem-596	138	38	containing	contain	VERB
eurjchem-596	138	39	(	(	PUNCT
eurjchem-596	138	40	0.5	0.5	NUM
eurjchem-596	138	41	ml	ml	NOUN
eurjchem-596	138	42	)	)	PUNCT
eurjchem-596	138	43	piperidine	piperidine	NOUN
eurjchem-596	138	44	was	be	AUX
eurjchem-596	138	45	refluxed	refluxe	VERB
eurjchem-596	138	46	for	for	ADP
eurjchem-596	138	47	6	6	NUM
eurjchem-596	138	48	h.	h.	NOUN
eurjchem-596	138	49	the	the	DET
eurjchem-596	138	50	reaction	reaction	NOUN
eurjchem-596	138	51	mixture	mixture	NOUN
eurjchem-596	138	52	was	be	AUX
eurjchem-596	138	53	cooled	cool	VERB
eurjchem-596	138	54	and	and	CCONJ
eurjchem-596	138	55	poured	pour	VERB
eurjchem-596	138	56	onto	onto	ADP
eurjchem-596	138	57	ice	ice	NOUN
eurjchem-596	138	58	water	water	NOUN
eurjchem-596	138	59	acidified	acidify	VERB
eurjchem-596	138	60	with	with	ADP
eurjchem-596	138	61	dil	dil	PROPN
eurjchem-596	138	62	.	.	PUNCT
eurjchem-596	139	1	hcl	hcl	PROPN
eurjchem-596	139	2	.	.	PUNCT
eurjchem-596	140	1	the	the	DET
eurjchem-596	140	2	solid	solid	ADJ
eurjchem-596	140	3	obtained	obtain	VERB
eurjchem-596	140	4	was	be	AUX
eurjchem-596	140	5	recrystallized	recrystallize	VERB
eurjchem-596	140	6	from	from	ADP
eurjchem-596	140	7	dioxane	dioxane	NOUN
eurjchem-596	140	8	to	to	PART
eurjchem-596	140	9	give	give	VERB
eurjchem-596	140	10	compounds	compound	NOUN
eurjchem-596	140	11	6a‐h	6a‐h	NOUN
eurjchem-596	140	12	(	(	PUNCT
eurjchem-596	140	13	scheme	scheme	NOUN
eurjchem-596	140	14	2	2	NUM
eurjchem-596	140	15	)	)	PUNCT
eurjchem-596	140	16	.	.	PUNCT
eurjchem-596	141	1	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐p‐tolyl‐1,2‐	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐p‐tolyl‐1,2‐	NOUN
eurjchem-596	141	2	dihydro‐	dihydro‐	NOUN
eurjchem-596	141	3	isoquinoline‐7‐carbonitrile	isoquinoline‐7‐carbonitrile	NOUN
eurjchem-596	141	4	(	(	PUNCT
eurjchem-596	141	5	6a	6a	NOUN
eurjchem-596	141	6	):	):	PUNCT
eurjchem-596	141	7	yield	yield	NOUN
eurjchem-596	141	8	:	:	PUNCT
eurjchem-596	141	9	90	90	NUM
eurjchem-596	141	10	%	%	NOUN
eurjchem-596	141	11	.	.	PUNCT
eurjchem-596	142	1	m.p	m.p	PROPN
eurjchem-596	142	2	.	.	PROPN
eurjchem-596	142	3	:	:	PUNCT
eurjchem-596	143	1	108‐	108‐	NUM
eurjchem-596	143	2	109	109	NUM
eurjchem-596	143	3	c	c	NUM
eurjchem-596	143	4	.	.	PUNCT
eurjchem-596	144	1	ir	ir	PROPN
eurjchem-596	144	2	(	(	PUNCT
eurjchem-596	144	3	kbr	kbr	PROPN
eurjchem-596	144	4	,	,	PUNCT
eurjchem-596	144	5	ν	ν	PROPN
eurjchem-596	144	6	,	,	PUNCT
eurjchem-596	144	7	cm–1	cm–1	PROPN
eurjchem-596	144	8	):	):	PUNCT
eurjchem-596	144	9	3325	3325	NUM
eurjchem-596	144	10	,	,	PUNCT
eurjchem-596	144	11	3209	3209	NUM
eurjchem-596	144	12	(	(	PUNCT
eurjchem-596	144	13	nh2	nh2	PROPN
eurjchem-596	144	14	)	)	PUNCT
eurjchem-596	144	15	,	,	PUNCT
eurjchem-596	144	16	3080	3080	NUM
eurjchem-596	144	17	(	(	PUNCT
eurjchem-596	144	18	ch	ch	NOUN
eurjchem-596	144	19	arom	arom	NOUN
eurjchem-596	144	20	.	.	PUNCT
eurjchem-596	144	21	)	)	PUNCT
eurjchem-596	144	22	,	,	PUNCT
eurjchem-596	144	23	2931	2931	NUM
eurjchem-596	144	24	,	,	PUNCT
eurjchem-596	144	25	2872	2872	NUM
eurjchem-596	144	26	(	(	PUNCT
eurjchem-596	144	27	ch	ch	NOUN
eurjchem-596	144	28	aliph	aliph	PROPN
eurjchem-596	144	29	.	.	PUNCT
eurjchem-596	144	30	)	)	PUNCT
eurjchem-596	144	31	,	,	PUNCT
eurjchem-596	144	32	2210	2210	NUM
eurjchem-596	144	33	(	(	PUNCT
eurjchem-596	144	34	c≡n	c≡n	PROPN
eurjchem-596	144	35	)	)	PUNCT
eurjchem-596	144	36	,	,	PUNCT
eurjchem-596	144	37	1658	1658	NUM
eurjchem-596	144	38	(	(	PUNCT
eurjchem-596	144	39	c	c	NOUN
eurjchem-596	144	40	=	=	NOUN
eurjchem-596	144	41	o	o	NOUN
eurjchem-596	144	42	)	)	PUNCT
eurjchem-596	144	43	.	.	PUNCT
eurjchem-596	145	1	1h	1h	NUM
eurjchem-596	145	2	nmr	nmr	NOUN
eurjchem-596	145	3	(	(	PUNCT
eurjchem-596	145	4	300	300	NUM
eurjchem-596	145	5	mhz	mhz	NOUN
eurjchem-596	145	6	,	,	PUNCT
eurjchem-596	145	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	145	8	,	,	PUNCT
eurjchem-596	145	9			NUM
eurjchem-596	145	10	,	,	PUNCT
eurjchem-596	145	11	ppm	ppm	NUM
eurjchem-596	145	12	):	):	PUNCT
eurjchem-596	145	13	1.2	1.2	NUM
eurjchem-596	145	14	(	(	PUNCT
eurjchem-596	145	15	t	t	PROPN
eurjchem-596	145	16	,	,	PUNCT
eurjchem-596	145	17	3h	3h	NUM
eurjchem-596	145	18	,	,	PUNCT
eurjchem-596	145	19	ch3	ch3	PROPN
eurjchem-596	145	20	,	,	PUNCT
eurjchem-596	145	21	j	j	PROPN
eurjchem-596	145	22	=	=	PROPN
eurjchem-596	145	23	0.66	0.66	NUM
eurjchem-596	145	24	hz	hz	NOUN
eurjchem-596	145	25	)	)	PUNCT
eurjchem-596	145	26	,	,	PUNCT
eurjchem-596	145	27	1.7	1.7	NUM
eurjchem-596	145	28	(	(	PUNCT
eurjchem-596	145	29	s	s	PROPN
eurjchem-596	145	30	,	,	PUNCT
eurjchem-596	145	31	3h	3h	NUM
eurjchem-596	145	32	,	,	PUNCT
eurjchem-596	145	33	ch3	ch3	PROPN
eurjchem-596	145	34	)	)	PUNCT
eurjchem-596	145	35	,	,	PUNCT
eurjchem-596	145	36	2.6	2.6	NUM
eurjchem-596	145	37	(	(	PUNCT
eurjchem-596	145	38	q	q	NOUN
eurjchem-596	145	39	,	,	PUNCT
eurjchem-596	145	40	2h	2h	NUM
eurjchem-596	145	41	,	,	PUNCT
eurjchem-596	145	42	ch2	ch2	PROPN
eurjchem-596	145	43	,	,	PUNCT
eurjchem-596	145	44	j	j	PROPN
eurjchem-596	145	45	=	=	PROPN
eurjchem-596	145	46	0.66	0.66	NUM
eurjchem-596	145	47	hz	hz	NOUN
eurjchem-596	145	48	)	)	PUNCT
eurjchem-596	145	49	,	,	PUNCT
eurjchem-596	145	50	5.7	5.7	NUM
eurjchem-596	145	51	(	(	PUNCT
eurjchem-596	145	52	s	s	PROPN
eurjchem-596	145	53	,	,	PUNCT
eurjchem-596	145	54	1h	1h	NUM
eurjchem-596	145	55	,	,	PUNCT
eurjchem-596	145	56	ch‐pyridine	ch‐pyridine	NOUN
eurjchem-596	145	57	)	)	PUNCT
eurjchem-596	145	58	,	,	PUNCT
eurjchem-596	145	59	6.9‐	6.9‐	NUM
eurjchem-596	145	60	7.5	7.5	NUM
eurjchem-596	145	61	(	(	PUNCT
eurjchem-596	145	62	m	m	PROPN
eurjchem-596	145	63	,	,	PUNCT
eurjchem-596	145	64	8h	8h	NUM
eurjchem-596	145	65	,	,	PUNCT
eurjchem-596	145	66	ar‐h	ar‐h	PROPN
eurjchem-596	145	67	)	)	PUNCT
eurjchem-596	145	68	,	,	PUNCT
eurjchem-596	145	69	8.7	8.7	NUM
eurjchem-596	145	70	(	(	PUNCT
eurjchem-596	145	71	s	s	PROPN
eurjchem-596	145	72	,	,	PUNCT
eurjchem-596	145	73	2h	2h	NUM
eurjchem-596	145	74	,	,	PUNCT
eurjchem-596	145	75	nh2	nh2	PROPN
eurjchem-596	145	76	,	,	PUNCT
eurjchem-596	145	77	exchangeable	exchangeable	ADJ
eurjchem-596	145	78	with	with	ADP
eurjchem-596	145	79	d2o	d2o	NOUN
eurjchem-596	145	80	)	)	PUNCT
eurjchem-596	145	81	.	.	PUNCT
eurjchem-596	146	1	13c	13c	NOUN
eurjchem-596	146	2	nmr	nmr	NOUN
eurjchem-596	146	3	(	(	PUNCT
eurjchem-596	146	4	75	75	NUM
eurjchem-596	146	5	mhz	mhz	NOUN
eurjchem-596	146	6	,	,	PUNCT
eurjchem-596	146	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	146	8	,	,	PUNCT
eurjchem-596	146	9			NUM
eurjchem-596	146	10	,	,	PUNCT
eurjchem-596	146	11	ppm	ppm	NUM
eurjchem-596	146	12	):	):	PUNCT
eurjchem-596	146	13	12.9	12.9	NUM
eurjchem-596	146	14	,	,	PUNCT
eurjchem-596	146	15	21.3	21.3	NUM
eurjchem-596	146	16	,	,	PUNCT
eurjchem-596	146	17	26.4	26.4	NUM
eurjchem-596	146	18	,	,	PUNCT
eurjchem-596	146	19	33.8	33.8	NUM
eurjchem-596	146	20	,	,	PUNCT
eurjchem-596	146	21	96.0	96.0	NUM
eurjchem-596	146	22	,	,	PUNCT
eurjchem-596	146	23	100.3	100.3	NUM
eurjchem-596	146	24	,	,	PUNCT
eurjchem-596	146	25	116.8	116.8	NUM
eurjchem-596	146	26	,	,	PUNCT
eurjchem-596	146	27	118.2	118.2	NUM
eurjchem-596	146	28	,	,	PUNCT
eurjchem-596	146	29	118.9	118.9	NUM
eurjchem-596	146	30	,	,	PUNCT
eurjchem-596	146	31	119.8	119.8	NUM
eurjchem-596	146	32	,	,	PUNCT
eurjchem-596	146	33	121.7	121.7	NUM
eurjchem-596	146	34	,	,	PUNCT
eurjchem-596	146	35	124.5	124.5	NUM
eurjchem-596	146	36	,	,	PUNCT
eurjchem-596	146	37	126.8	126.8	NUM
eurjchem-596	146	38	,	,	PUNCT
eurjchem-596	146	39	127.6	127.6	NUM
eurjchem-596	146	40	,	,	PUNCT
eurjchem-596	146	41	130.9	130.9	NUM
eurjchem-596	146	42	,	,	PUNCT
eurjchem-596	146	43	133.4	133.4	NUM
eurjchem-596	146	44	,	,	PUNCT
eurjchem-596	146	45	134.8	134.8	NUM
eurjchem-596	146	46	,	,	PUNCT
eurjchem-596	146	47	139.0	139.0	NUM
eurjchem-596	146	48	,	,	PUNCT
eurjchem-596	146	49	140.9	140.9	NUM
eurjchem-596	146	50	,	,	PUNCT
eurjchem-596	146	51	142.4	142.4	NUM
eurjchem-596	146	52	,	,	PUNCT
eurjchem-596	146	53	144.6	144.6	NUM
eurjchem-596	146	54	,	,	PUNCT
eurjchem-596	146	55	147.8	147.8	NUM
eurjchem-596	146	56	,	,	PUNCT
eurjchem-596	146	57	151.3	151.3	NUM
eurjchem-596	146	58	,	,	PUNCT
eurjchem-596	146	59	158.4	158.4	NUM
eurjchem-596	146	60	.	.	PUNCT
eurjchem-596	146	61	anal	anal	PROPN
eurjchem-596	146	62	.	.	PUNCT
eurjchem-596	146	63	calcd	calcd	NOUN
eurjchem-596	146	64	.	.	PUNCT
eurjchem-596	147	1	for	for	ADP
eurjchem-596	147	2	c26h23n3o	c26h23n3o	NOUN
eurjchem-596	147	3	:	:	PUNCT
eurjchem-596	147	4	c	c	X
eurjchem-596	147	5	,	,	PUNCT
eurjchem-596	147	6	79.36	79.36	NUM
eurjchem-596	147	7	;	;	PUNCT
eurjchem-596	147	8	h	h	NOUN
eurjchem-596	147	9	,	,	PUNCT
eurjchem-596	147	10	5.89	5.89	NUM
eurjchem-596	147	11	;	;	PUNCT
eurjchem-596	147	12	n	n	CCONJ
eurjchem-596	147	13	,	,	PUNCT
eurjchem-596	147	14	10.68	10.68	NUM
eurjchem-596	147	15	.	.	PUNCT
eurjchem-596	147	16	found	find	VERB
eurjchem-596	147	17	:	:	PUNCT
eurjchem-596	148	1	c	c	X
eurjchem-596	148	2	,	,	PUNCT
eurjchem-596	148	3	79.50	79.50	NUM
eurjchem-596	148	4	;	;	PUNCT
eurjchem-596	148	5	h	h	NOUN
eurjchem-596	148	6	,	,	PUNCT
eurjchem-596	148	7	5.70	5.70	NUM
eurjchem-596	148	8	;	;	PUNCT
eurjchem-596	148	9	n	n	CCONJ
eurjchem-596	148	10	,	,	PUNCT
eurjchem-596	148	11	10.40	10.40	NUM
eurjchem-596	148	12	%	%	NOUN
eurjchem-596	148	13	.	.	PUNCT
eurjchem-596	149	1	amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(2‐methoxy	amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(2‐methoxy	INTJ
eurjchem-596	150	1	phenyl)‐1,2‐dihydro‐	phenyl)‐1,2‐dihydro‐	PROPN
eurjchem-596	150	2	isoquinoline‐7‐carbonitrile	isoquinoline‐7‐carbonitrile	PROPN
eurjchem-596	150	3	(	(	PUNCT
eurjchem-596	150	4	6b	6b	NOUN
eurjchem-596	150	5	):	):	PUNCT
eurjchem-596	150	6	yield	yield	NOUN
eurjchem-596	150	7	:	:	PUNCT
eurjchem-596	150	8	92	92	NUM
eurjchem-596	150	9	%	%	NOUN
eurjchem-596	150	10	.	.	PUNCT
eurjchem-596	151	1	m.p	m.p	PROPN
eurjchem-596	151	2	.	.	PROPN
eurjchem-596	151	3	:	:	PUNCT
eurjchem-596	152	1	114‐116	114‐116	NUM
eurjchem-596	152	2	c	c	ADJ
eurjchem-596	152	3	.	.	PUNCT
eurjchem-596	153	1	ir	ir	PROPN
eurjchem-596	153	2	(	(	PUNCT
eurjchem-596	153	3	kbr	kbr	PROPN
eurjchem-596	153	4	,	,	PUNCT
eurjchem-596	153	5	ν	ν	PROPN
eurjchem-596	153	6	,	,	PUNCT
eurjchem-596	153	7	cm–1	cm–1	PROPN
eurjchem-596	153	8	):	):	PUNCT
eurjchem-596	153	9	3325	3325	NUM
eurjchem-596	153	10	,	,	PUNCT
eurjchem-596	153	11	3209	3209	NUM
eurjchem-596	153	12	(	(	PUNCT
eurjchem-596	153	13	nh2	nh2	PROPN
eurjchem-596	153	14	)	)	PUNCT
eurjchem-596	153	15	,	,	PUNCT
eurjchem-596	153	16	3080	3080	NUM
eurjchem-596	153	17	(	(	PUNCT
eurjchem-596	153	18	ch	ch	NOUN
eurjchem-596	153	19	arom	arom	NOUN
eurjchem-596	153	20	.	.	PUNCT
eurjchem-596	153	21	)	)	PUNCT
eurjchem-596	153	22	,	,	PUNCT
eurjchem-596	153	23	2931	2931	NUM
eurjchem-596	153	24	,	,	PUNCT
eurjchem-596	153	25	2872	2872	NUM
eurjchem-596	153	26	(	(	PUNCT
eurjchem-596	153	27	ch	ch	NOUN
eurjchem-596	153	28	aliph	aliph	PROPN
eurjchem-596	153	29	.	.	PUNCT
eurjchem-596	153	30	)	)	PUNCT
eurjchem-596	153	31	,	,	PUNCT
eurjchem-596	153	32	2212	2212	NUM
eurjchem-596	153	33	(	(	PUNCT
eurjchem-596	153	34	c≡n	c≡n	PROPN
eurjchem-596	153	35	)	)	PUNCT
eurjchem-596	153	36	,	,	PUNCT
eurjchem-596	153	37	1658	1658	NUM
eurjchem-596	153	38	(	(	PUNCT
eurjchem-596	153	39	c	c	NOUN
eurjchem-596	153	40	=	=	NOUN
eurjchem-596	153	41	o	o	NOUN
eurjchem-596	153	42	)	)	PUNCT
eurjchem-596	153	43	.	.	PUNCT
eurjchem-596	154	1	1h	1h	NUM
eurjchem-596	154	2	nmr	nmr	NOUN
eurjchem-596	154	3	(	(	PUNCT
eurjchem-596	154	4	300	300	NUM
eurjchem-596	154	5	mhz	mhz	NOUN
eurjchem-596	154	6	,	,	PUNCT
eurjchem-596	154	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	154	8	,	,	PUNCT
eurjchem-596	154	9			NUM
eurjchem-596	154	10	,	,	PUNCT
eurjchem-596	154	11	ppm	ppm	NUM
eurjchem-596	154	12	):	):	PUNCT
eurjchem-596	154	13	1.2	1.2	NUM
eurjchem-596	154	14	(	(	PUNCT
eurjchem-596	154	15	t	t	PROPN
eurjchem-596	154	16	,	,	PUNCT
eurjchem-596	154	17	3h	3h	NUM
eurjchem-596	154	18	,	,	PUNCT
eurjchem-596	154	19	ch3	ch3	PROPN
eurjchem-596	154	20	,	,	PUNCT
eurjchem-596	154	21	j	j	PROPN
eurjchem-596	154	22	=	=	PROPN
eurjchem-596	154	23	0.66	0.66	NUM
eurjchem-596	154	24	hz	hz	NOUN
eurjchem-596	154	25	)	)	PUNCT
eurjchem-596	154	26	,	,	PUNCT
eurjchem-596	154	27	2.6	2.6	NUM
eurjchem-596	154	28	(	(	PUNCT
eurjchem-596	154	29	q	q	NOUN
eurjchem-596	154	30	,	,	PUNCT
eurjchem-596	154	31	2h	2h	NUM
eurjchem-596	154	32	,	,	PUNCT
eurjchem-596	154	33	ch2	ch2	PROPN
eurjchem-596	154	34	,	,	PUNCT
eurjchem-596	154	35	j	j	PROPN
eurjchem-596	154	36	=	=	PROPN
eurjchem-596	154	37	0.66	0.66	NUM
eurjchem-596	154	38	hz	hz	NOUN
eurjchem-596	154	39	)	)	PUNCT
eurjchem-596	154	40	,	,	PUNCT
eurjchem-596	154	41	3.8	3.8	NUM
eurjchem-596	154	42	(	(	PUNCT
eurjchem-596	154	43	s	s	PROPN
eurjchem-596	154	44	,	,	PUNCT
eurjchem-596	154	45	3h	3h	NUM
eurjchem-596	154	46	,	,	PUNCT
eurjchem-596	154	47	och3	och3	ADJ
eurjchem-596	154	48	)	)	PUNCT
eurjchem-596	154	49	,	,	PUNCT
eurjchem-596	154	50	5.7	5.7	NUM
eurjchem-596	154	51	(	(	PUNCT
eurjchem-596	154	52	s	s	PROPN
eurjchem-596	154	53	,	,	PUNCT
eurjchem-596	154	54	1h	1h	NUM
eurjchem-596	154	55	,	,	PUNCT
eurjchem-596	154	56	ch‐pyridine	ch‐pyridine	NOUN
eurjchem-596	154	57	)	)	PUNCT
eurjchem-596	154	58	,	,	PUNCT
eurjchem-596	154	59	6.9‐7.9	6.9‐7.9	NUM
eurjchem-596	154	60	(	(	PUNCT
eurjchem-596	154	61	m	m	PROPN
eurjchem-596	154	62	,	,	PUNCT
eurjchem-596	154	63	8h	8h	NUM
eurjchem-596	154	64	,	,	PUNCT
eurjchem-596	154	65	ar‐h	ar‐h	PROPN
eurjchem-596	154	66	)	)	PUNCT
eurjchem-596	154	67	,	,	PUNCT
eurjchem-596	154	68	8.7	8.7	NUM
eurjchem-596	154	69	(	(	PUNCT
eurjchem-596	154	70	s	s	PROPN
eurjchem-596	154	71	,	,	PUNCT
eurjchem-596	154	72	2h	2h	NUM
eurjchem-596	154	73	,	,	PUNCT
eurjchem-596	154	74	nh2	nh2	PROPN
eurjchem-596	154	75	,	,	PUNCT
eurjchem-596	154	76	exchangeable	exchangeable	ADJ
eurjchem-596	154	77	with	with	ADP
eurjchem-596	154	78	d2o	d2o	NOUN
eurjchem-596	154	79	)	)	PUNCT
eurjchem-596	154	80	.	.	PUNCT
eurjchem-596	155	1	ms	ms	NOUN
eurjchem-596	155	2	(	(	PUNCT
eurjchem-596	155	3	m	m	PROPN
eurjchem-596	155	4	/	/	SYM
eurjchem-596	155	5	z	z	NOUN
eurjchem-596	155	6	,	,	PUNCT
eurjchem-596	155	7	%	%	INTJ
eurjchem-596	155	8	):	):	PUNCT
eurjchem-596	155	9	409	409	NUM
eurjchem-596	155	10	(	(	PUNCT
eurjchem-596	155	11	m+	m+	NUM
eurjchem-596	155	12	,	,	PUNCT
eurjchem-596	155	13	5.12	5.12	NUM
eurjchem-596	155	14	)	)	PUNCT
eurjchem-596	155	15	,	,	PUNCT
eurjchem-596	155	16	105	105	NUM
eurjchem-596	155	17	(	(	PUNCT
eurjchem-596	155	18	100	100	NUM
eurjchem-596	155	19	)	)	PUNCT
eurjchem-596	155	20	.	.	PUNCT
eurjchem-596	156	1	anal	anal	PROPN
eurjchem-596	156	2	.	.	PUNCT
eurjchem-596	156	3	calcd	calcd	NOUN
eurjchem-596	156	4	.	.	PUNCT
eurjchem-596	157	1	for	for	SCONJ
eurjchem-596	157	2	c26h23n3o2	c26h23n3o2	NOUN
eurjchem-596	157	3	:	:	PUNCT
eurjchem-596	157	4	c	c	X
eurjchem-596	157	5	,	,	PUNCT
eurjchem-596	157	6	76.26	76.26	NUM
eurjchem-596	157	7	;	;	PUNCT
eurjchem-596	157	8	h	h	NOUN
eurjchem-596	157	9	,	,	PUNCT
eurjchem-596	157	10	5.66	5.66	NUM
eurjchem-596	157	11	;	;	PUNCT
eurjchem-596	157	12	n	n	CCONJ
eurjchem-596	157	13	,	,	PUNCT
eurjchem-596	157	14	10.26	10.26	NUM
eurjchem-596	157	15	.	.	PUNCT
eurjchem-596	157	16	found	find	VERB
eurjchem-596	157	17	:	:	PUNCT
eurjchem-596	158	1	c	c	X
eurjchem-596	158	2	,	,	PUNCT
eurjchem-596	158	3	76.50	76.50	NUM
eurjchem-596	158	4	;	;	PUNCT
eurjchem-596	158	5	h	h	NOUN
eurjchem-596	158	6	,	,	PUNCT
eurjchem-596	158	7	5.70	5.70	NUM
eurjchem-596	158	8	;	;	PUNCT
eurjchem-596	158	9	n	n	CCONJ
eurjchem-596	158	10	,	,	PUNCT
eurjchem-596	158	11	10.50	10.50	NUM
eurjchem-596	158	12	%	%	NOUN
eurjchem-596	158	13	.	.	PUNCT
eurjchem-596	159	1	al‐said	al‐said	PROPN
eurjchem-596	159	2	et	et	PROPN
eurjchem-596	159	3	al	al	PROPN
eurjchem-596	159	4	.	.	PUNCT
eurjchem-596	159	5	/	/	SYM
eurjchem-596	159	6	european	european	PROPN
eurjchem-596	159	7	journal	journal	PROPN
eurjchem-596	159	8	of	of	ADP
eurjchem-596	159	9	chemistry	chemistry	NOUN
eurjchem-596	159	10	3	3	NUM
eurjchem-596	159	11	(	(	PUNCT
eurjchem-596	159	12	2	2	NUM
eurjchem-596	159	13	)	)	PUNCT
eurjchem-596	159	14	(	(	PUNCT
eurjchem-596	159	15	2012	2012	NUM
eurjchem-596	159	16	)	)	PUNCT
eurjchem-596	159	17	228‐234	228‐234	PROPN
eurjchem-596	159	18	231	231	NUM
eurjchem-596	159	19	scheme	scheme	NOUN
eurjchem-596	159	20	3	3	NUM
eurjchem-596	159	21	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(4‐methoxy	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(4‐methoxy	NUM
eurjchem-596	159	22	phenyl)‐1,2‐dihydro‐isoquinoline‐7‐carbonitrile	phenyl)‐1,2‐dihydro‐isoquinoline‐7‐carbonitrile	NOUN
eurjchem-596	159	23	(	(	PUNCT
eurjchem-596	159	24	6c	6c	NOUN
eurjchem-596	159	25	):	):	PUNCT
eurjchem-596	159	26	yield	yield	NOUN
eurjchem-596	159	27	:	:	PUNCT
eurjchem-596	159	28	97	97	NUM
eurjchem-596	159	29	%	%	NOUN
eurjchem-596	159	30	.	.	PUNCT
eurjchem-596	160	1	m.p	m.p	PROPN
eurjchem-596	160	2	.	.	PROPN
eurjchem-596	160	3	:	:	PUNCT
eurjchem-596	161	1	122‐124	122‐124	NUM
eurjchem-596	161	2	c	c	ADJ
eurjchem-596	161	3	.	.	PUNCT
eurjchem-596	162	1	ir	ir	PROPN
eurjchem-596	162	2	(	(	PUNCT
eurjchem-596	162	3	kbr	kbr	PROPN
eurjchem-596	162	4	,	,	PUNCT
eurjchem-596	162	5	ν	ν	PROPN
eurjchem-596	162	6	,	,	PUNCT
eurjchem-596	162	7	cm–1	cm–1	PROPN
eurjchem-596	162	8	):	):	PUNCT
eurjchem-596	162	9	3325	3325	NUM
eurjchem-596	162	10	,	,	PUNCT
eurjchem-596	162	11	3209	3209	NUM
eurjchem-596	162	12	(	(	PUNCT
eurjchem-596	162	13	nh2	nh2	PROPN
eurjchem-596	162	14	)	)	PUNCT
eurjchem-596	162	15	,	,	PUNCT
eurjchem-596	162	16	3080	3080	NUM
eurjchem-596	162	17	(	(	PUNCT
eurjchem-596	162	18	ch	ch	NOUN
eurjchem-596	162	19	arom	arom	NOUN
eurjchem-596	162	20	.	.	PUNCT
eurjchem-596	162	21	)	)	PUNCT
eurjchem-596	162	22	,	,	PUNCT
eurjchem-596	162	23	2931	2931	NUM
eurjchem-596	162	24	,	,	PUNCT
eurjchem-596	162	25	2860	2860	NUM
eurjchem-596	162	26	(	(	PUNCT
eurjchem-596	162	27	ch	ch	NOUN
eurjchem-596	162	28	aliph	aliph	PROPN
eurjchem-596	162	29	.	.	PUNCT
eurjchem-596	162	30	)	)	PUNCT
eurjchem-596	162	31	,	,	PUNCT
eurjchem-596	162	32	2200	2200	NUM
eurjchem-596	162	33	(	(	PUNCT
eurjchem-596	162	34	c≡n	c≡n	PROPN
eurjchem-596	162	35	)	)	PUNCT
eurjchem-596	162	36	,	,	PUNCT
eurjchem-596	162	37	1658	1658	NUM
eurjchem-596	162	38	(	(	PUNCT
eurjchem-596	162	39	c	c	NOUN
eurjchem-596	162	40	=	=	NOUN
eurjchem-596	162	41	o	o	NOUN
eurjchem-596	162	42	)	)	PUNCT
eurjchem-596	162	43	.	.	PUNCT
eurjchem-596	163	1	1h	1h	NUM
eurjchem-596	163	2	nmr	nmr	NOUN
eurjchem-596	163	3	(	(	PUNCT
eurjchem-596	163	4	300	300	NUM
eurjchem-596	163	5	mhz	mhz	NOUN
eurjchem-596	163	6	,	,	PUNCT
eurjchem-596	163	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	163	8	,	,	PUNCT
eurjchem-596	163	9			NUM
eurjchem-596	163	10	,	,	PUNCT
eurjchem-596	163	11	ppm	ppm	NUM
eurjchem-596	163	12	):	):	PUNCT
eurjchem-596	163	13	1.2	1.2	NUM
eurjchem-596	163	14	(	(	PUNCT
eurjchem-596	163	15	t	t	PROPN
eurjchem-596	163	16	,	,	PUNCT
eurjchem-596	163	17	3h	3h	NUM
eurjchem-596	163	18	,	,	PUNCT
eurjchem-596	163	19	ch3	ch3	PROPN
eurjchem-596	163	20	,	,	PUNCT
eurjchem-596	163	21	j	j	PROPN
eurjchem-596	163	22	=	=	PROPN
eurjchem-596	163	23	0.66	0.66	NUM
eurjchem-596	163	24	hz	hz	NOUN
eurjchem-596	163	25	)	)	PUNCT
eurjchem-596	163	26	,	,	PUNCT
eurjchem-596	163	27	2.6	2.6	NUM
eurjchem-596	163	28	(	(	PUNCT
eurjchem-596	163	29	q	q	NOUN
eurjchem-596	163	30	,	,	PUNCT
eurjchem-596	163	31	2h	2h	NUM
eurjchem-596	163	32	,	,	PUNCT
eurjchem-596	163	33	ch2	ch2	PROPN
eurjchem-596	163	34	,	,	PUNCT
eurjchem-596	163	35	j	j	PROPN
eurjchem-596	163	36	=	=	PROPN
eurjchem-596	163	37	0.66	0.66	NUM
eurjchem-596	163	38	hz	hz	NOUN
eurjchem-596	163	39	)	)	PUNCT
eurjchem-596	163	40	,	,	PUNCT
eurjchem-596	163	41	3.7	3.7	NUM
eurjchem-596	163	42	(	(	PUNCT
eurjchem-596	163	43	s	s	PROPN
eurjchem-596	163	44	,	,	PUNCT
eurjchem-596	163	45	3h	3h	NUM
eurjchem-596	163	46	,	,	PUNCT
eurjchem-596	163	47	och3	och3	ADJ
eurjchem-596	163	48	)	)	PUNCT
eurjchem-596	163	49	,	,	PUNCT
eurjchem-596	163	50	5.7	5.7	NUM
eurjchem-596	163	51	(	(	PUNCT
eurjchem-596	163	52	s	s	PROPN
eurjchem-596	163	53	,	,	PUNCT
eurjchem-596	163	54	1h	1h	NUM
eurjchem-596	163	55	,	,	PUNCT
eurjchem-596	163	56	ch‐	ch‐	NOUN
eurjchem-596	163	57	pyridine	pyridine	NOUN
eurjchem-596	163	58	)	)	PUNCT
eurjchem-596	163	59	,	,	PUNCT
eurjchem-596	163	60	6.9‐7.8	6.9‐7.8	PROPN
eurjchem-596	163	61	(	(	PUNCT
eurjchem-596	163	62	m	m	PROPN
eurjchem-596	163	63	,	,	PUNCT
eurjchem-596	163	64	8h	8h	NUM
eurjchem-596	163	65	,	,	PUNCT
eurjchem-596	163	66	ar‐h	ar‐h	PROPN
eurjchem-596	163	67	)	)	PUNCT
eurjchem-596	163	68	,	,	PUNCT
eurjchem-596	163	69	8.7	8.7	NUM
eurjchem-596	163	70	(	(	PUNCT
eurjchem-596	163	71	s	s	PROPN
eurjchem-596	163	72	,	,	PUNCT
eurjchem-596	163	73	2h	2h	NUM
eurjchem-596	163	74	,	,	PUNCT
eurjchem-596	163	75	nh2	nh2	PROPN
eurjchem-596	163	76	,	,	PUNCT
eurjchem-596	163	77	exchangeable	exchangeable	ADJ
eurjchem-596	163	78	with	with	ADP
eurjchem-596	163	79	d2o	d2o	NOUN
eurjchem-596	163	80	)	)	PUNCT
eurjchem-596	163	81	.	.	PUNCT
eurjchem-596	164	1	ms	ms	NOUN
eurjchem-596	164	2	(	(	PUNCT
eurjchem-596	164	3	m	m	PROPN
eurjchem-596	164	4	/	/	SYM
eurjchem-596	164	5	z	z	NOUN
eurjchem-596	164	6	,	,	PUNCT
eurjchem-596	164	7	%	%	INTJ
eurjchem-596	164	8	):	):	PUNCT
eurjchem-596	164	9	409	409	NUM
eurjchem-596	164	10	(	(	PUNCT
eurjchem-596	164	11	m+	m+	NUM
eurjchem-596	164	12	,	,	PUNCT
eurjchem-596	164	13	12.1	12.1	NUM
eurjchem-596	164	14	)	)	PUNCT
eurjchem-596	164	15	,	,	PUNCT
eurjchem-596	164	16	90	90	NUM
eurjchem-596	164	17	(	(	PUNCT
eurjchem-596	164	18	100	100	NUM
eurjchem-596	164	19	)	)	PUNCT
eurjchem-596	164	20	.	.	PUNCT
eurjchem-596	165	1	anal	anal	PROPN
eurjchem-596	165	2	.	.	PUNCT
eurjchem-596	165	3	calcd	calcd	NOUN
eurjchem-596	165	4	.	.	PUNCT
eurjchem-596	166	1	for	for	SCONJ
eurjchem-596	166	2	c26h23n3o2	c26h23n3o2	NOUN
eurjchem-596	166	3	:	:	PUNCT
eurjchem-596	166	4	c	c	X
eurjchem-596	166	5	,	,	PUNCT
eurjchem-596	166	6	76.26	76.26	NUM
eurjchem-596	166	7	;	;	PUNCT
eurjchem-596	166	8	h	h	NOUN
eurjchem-596	166	9	,	,	PUNCT
eurjchem-596	166	10	5.66	5.66	NUM
eurjchem-596	166	11	;	;	PUNCT
eurjchem-596	166	12	n	n	CCONJ
eurjchem-596	166	13	,	,	PUNCT
eurjchem-596	166	14	10.26	10.26	NUM
eurjchem-596	166	15	.	.	PUNCT
eurjchem-596	166	16	found	find	VERB
eurjchem-596	166	17	:	:	PUNCT
eurjchem-596	167	1	c	c	X
eurjchem-596	167	2	,	,	PUNCT
eurjchem-596	167	3	76.60	76.60	NUM
eurjchem-596	167	4	;	;	PUNCT
eurjchem-596	167	5	h	h	NOUN
eurjchem-596	167	6	,	,	PUNCT
eurjchem-596	167	7	5.70	5.70	NUM
eurjchem-596	167	8	;	;	PUNCT
eurjchem-596	167	9	n	n	CCONJ
eurjchem-596	167	10	,	,	PUNCT
eurjchem-596	167	11	10.10	10.10	NUM
eurjchem-596	167	12	%	%	NOUN
eurjchem-596	167	13	.	.	PUNCT
eurjchem-596	168	1	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(3‐nitro	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(3‐nitro	NUM
eurjchem-596	168	2	phenyl)‐1,2‐dihydro‐isoquinoline‐7‐carbonitrile	phenyl)‐1,2‐dihydro‐isoquinoline‐7‐carbonitrile	ADJ
eurjchem-596	168	3	(	(	PUNCT
eurjchem-596	168	4	6d	6d	NUM
eurjchem-596	168	5	):	):	PUNCT
eurjchem-596	168	6	yield	yield	NOUN
eurjchem-596	168	7	:	:	PUNCT
eurjchem-596	168	8	89	89	NUM
eurjchem-596	168	9	%	%	NOUN
eurjchem-596	168	10	.	.	PUNCT
eurjchem-596	169	1	m.p	m.p	PROPN
eurjchem-596	169	2	.	.	PROPN
eurjchem-596	169	3	:	:	PUNCT
eurjchem-596	170	1	98‐100	98‐100	NUM
eurjchem-596	170	2	c	c	ADJ
eurjchem-596	170	3	.	.	PUNCT
eurjchem-596	171	1	ir	ir	PROPN
eurjchem-596	171	2	(	(	PUNCT
eurjchem-596	171	3	kbr	kbr	PROPN
eurjchem-596	171	4	,	,	PUNCT
eurjchem-596	171	5	ν	ν	PROPN
eurjchem-596	171	6	,	,	PUNCT
eurjchem-596	171	7	cm–1	cm–1	PROPN
eurjchem-596	171	8	):	):	PUNCT
eurjchem-596	171	9	3325	3325	NUM
eurjchem-596	171	10	,	,	PUNCT
eurjchem-596	171	11	3220	3220	NUM
eurjchem-596	171	12	(	(	PUNCT
eurjchem-596	171	13	nh2	nh2	PROPN
eurjchem-596	171	14	)	)	PUNCT
eurjchem-596	171	15	,	,	PUNCT
eurjchem-596	171	16	3080	3080	NUM
eurjchem-596	171	17	(	(	PUNCT
eurjchem-596	171	18	ch	ch	NOUN
eurjchem-596	171	19	arom	arom	NOUN
eurjchem-596	171	20	.	.	PUNCT
eurjchem-596	171	21	)	)	PUNCT
eurjchem-596	171	22	,	,	PUNCT
eurjchem-596	171	23	2931	2931	NUM
eurjchem-596	171	24	,	,	PUNCT
eurjchem-596	171	25	2850(ch	2850(ch	NUM
eurjchem-596	171	26	aliph	aliph	VERB
eurjchem-596	171	27	.	.	PUNCT
eurjchem-596	171	28	)	)	PUNCT
eurjchem-596	171	29	,	,	PUNCT
eurjchem-596	171	30	2208	2208	NUM
eurjchem-596	171	31	(	(	PUNCT
eurjchem-596	171	32	c≡n	c≡n	PROPN
eurjchem-596	171	33	)	)	PUNCT
eurjchem-596	171	34	,	,	PUNCT
eurjchem-596	171	35	1658	1658	NUM
eurjchem-596	171	36	(	(	PUNCT
eurjchem-596	171	37	c	c	NOUN
eurjchem-596	171	38	=	=	NOUN
eurjchem-596	171	39	o	o	NOUN
eurjchem-596	171	40	)	)	PUNCT
eurjchem-596	171	41	.	.	PUNCT
eurjchem-596	172	1	1h	1h	NUM
eurjchem-596	172	2	nmr	nmr	NOUN
eurjchem-596	172	3	(	(	PUNCT
eurjchem-596	172	4	300	300	NUM
eurjchem-596	172	5	mhz	mhz	NOUN
eurjchem-596	172	6	,	,	PUNCT
eurjchem-596	172	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	172	8	,	,	PUNCT
eurjchem-596	172	9			NUM
eurjchem-596	172	10	,	,	PUNCT
eurjchem-596	172	11	ppm	ppm	NUM
eurjchem-596	172	12	):	):	PUNCT
eurjchem-596	172	13	1.2	1.2	NUM
eurjchem-596	172	14	(	(	PUNCT
eurjchem-596	172	15	t	t	PROPN
eurjchem-596	172	16	,	,	PUNCT
eurjchem-596	172	17	3h	3h	NUM
eurjchem-596	172	18	,	,	PUNCT
eurjchem-596	172	19	ch3	ch3	PROPN
eurjchem-596	172	20	,	,	PUNCT
eurjchem-596	172	21	j	j	PROPN
eurjchem-596	172	22	=	=	PROPN
eurjchem-596	172	23	0.66	0.66	NUM
eurjchem-596	172	24	hz	hz	NOUN
eurjchem-596	172	25	)	)	PUNCT
eurjchem-596	172	26	,	,	PUNCT
eurjchem-596	172	27	2.6	2.6	NUM
eurjchem-596	172	28	(	(	PUNCT
eurjchem-596	172	29	q	q	NOUN
eurjchem-596	172	30	,	,	PUNCT
eurjchem-596	172	31	2h	2h	NUM
eurjchem-596	172	32	,	,	PUNCT
eurjchem-596	172	33	ch2	ch2	PROPN
eurjchem-596	172	34	,	,	PUNCT
eurjchem-596	172	35	j	j	PROPN
eurjchem-596	172	36	=	=	PROPN
eurjchem-596	172	37	0.66	0.66	NUM
eurjchem-596	172	38	hz	hz	NOUN
eurjchem-596	172	39	)	)	PUNCT
eurjchem-596	172	40	,	,	PUNCT
eurjchem-596	172	41	5.7	5.7	NUM
eurjchem-596	172	42	(	(	PUNCT
eurjchem-596	172	43	s	s	PROPN
eurjchem-596	172	44	,	,	PUNCT
eurjchem-596	172	45	1h	1h	NUM
eurjchem-596	172	46	,	,	PUNCT
eurjchem-596	172	47	ch‐pyridine	ch‐pyridine	NOUN
eurjchem-596	172	48	)	)	PUNCT
eurjchem-596	172	49	,	,	PUNCT
eurjchem-596	172	50	6.9‐7.5	6.9‐7.5	NUM
eurjchem-596	172	51	(	(	PUNCT
eurjchem-596	172	52	m	m	PROPN
eurjchem-596	172	53	,	,	PUNCT
eurjchem-596	172	54	8h	8h	NUM
eurjchem-596	172	55	,	,	PUNCT
eurjchem-596	172	56	ar‐h	ar‐h	PROPN
eurjchem-596	172	57	)	)	PUNCT
eurjchem-596	172	58	,	,	PUNCT
eurjchem-596	172	59	8.7	8.7	NUM
eurjchem-596	172	60	(	(	PUNCT
eurjchem-596	172	61	s	s	PROPN
eurjchem-596	172	62	,	,	PUNCT
eurjchem-596	172	63	2h	2h	NUM
eurjchem-596	172	64	,	,	PUNCT
eurjchem-596	172	65	nh2	nh2	PROPN
eurjchem-596	172	66	,	,	PUNCT
eurjchem-596	172	67	exchangeable	exchangeable	ADJ
eurjchem-596	172	68	with	with	ADP
eurjchem-596	172	69	d2o	d2o	NOUN
eurjchem-596	172	70	)	)	PUNCT
eurjchem-596	172	71	.	.	PUNCT
eurjchem-596	173	1	ms	ms	NOUN
eurjchem-596	173	2	(	(	PUNCT
eurjchem-596	173	3	m	m	PROPN
eurjchem-596	173	4	/	/	SYM
eurjchem-596	173	5	z	z	NOUN
eurjchem-596	173	6	,	,	PUNCT
eurjchem-596	173	7	%	%	INTJ
eurjchem-596	173	8	):	):	PUNCT
eurjchem-596	173	9	424	424	NUM
eurjchem-596	173	10	(	(	PUNCT
eurjchem-596	173	11	m+	m+	NUM
eurjchem-596	173	12	,	,	PUNCT
eurjchem-596	173	13	18.2	18.2	NUM
eurjchem-596	173	14	)	)	PUNCT
eurjchem-596	173	15	,	,	PUNCT
eurjchem-596	173	16	90	90	NUM
eurjchem-596	173	17	(	(	PUNCT
eurjchem-596	173	18	100	100	NUM
eurjchem-596	173	19	)	)	PUNCT
eurjchem-596	173	20	.	.	PUNCT
eurjchem-596	174	1	anal	anal	PROPN
eurjchem-596	174	2	.	.	PUNCT
eurjchem-596	174	3	calcd	calcd	NOUN
eurjchem-596	174	4	.	.	PUNCT
eurjchem-596	175	1	for	for	ADP
eurjchem-596	175	2	c25h20n4o3	c25h20n4o3	PROPN
eurjchem-596	175	3	:	:	PUNCT
eurjchem-596	175	4	c	c	X
eurjchem-596	175	5	,	,	PUNCT
eurjchem-596	175	6	70.74	70.74	NUM
eurjchem-596	175	7	;	;	PUNCT
eurjchem-596	175	8	h	h	X
eurjchem-596	175	9	,	,	PUNCT
eurjchem-596	175	10	4.75	4.75	NUM
eurjchem-596	175	11	;	;	PUNCT
eurjchem-596	175	12	n	n	CCONJ
eurjchem-596	175	13	,	,	PUNCT
eurjchem-596	175	14	13.20	13.20	NUM
eurjchem-596	175	15	.	.	PUNCT
eurjchem-596	175	16	found	find	VERB
eurjchem-596	175	17	:	:	PUNCT
eurjchem-596	176	1	c	c	X
eurjchem-596	176	2	,	,	PUNCT
eurjchem-596	176	3	70.50	70.50	NUM
eurjchem-596	176	4	;	;	PUNCT
eurjchem-596	176	5	h	h	NOUN
eurjchem-596	176	6	,	,	PUNCT
eurjchem-596	176	7	4.70	4.70	NUM
eurjchem-596	176	8	;	;	PUNCT
eurjchem-596	176	9	n	n	CCONJ
eurjchem-596	176	10	,	,	PUNCT
eurjchem-596	176	11	13.40	13.40	NUM
eurjchem-596	176	12	.	.	PUNCT
eurjchem-596	176	13	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(4‐nitro	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(4‐nitro	NUM
eurjchem-596	176	14	phenyl)‐1,2‐dihydro‐isoquinoline‐7‐carbonitrile	phenyl)‐1,2‐dihydro‐isoquinoline‐7‐carbonitrile	ADJ
eurjchem-596	176	15	(	(	PUNCT
eurjchem-596	176	16	6e	6e	NOUN
eurjchem-596	176	17	):	):	PUNCT
eurjchem-596	176	18	yield	yield	NOUN
eurjchem-596	176	19	:	:	PUNCT
eurjchem-596	176	20	85	85	NUM
eurjchem-596	176	21	%	%	NOUN
eurjchem-596	176	22	.	.	PUNCT
eurjchem-596	177	1	m.p	m.p	PROPN
eurjchem-596	177	2	.	.	PROPN
eurjchem-596	177	3	:	:	PUNCT
eurjchem-596	178	1	106‐108	106‐108	NUM
eurjchem-596	178	2	c	c	ADJ
eurjchem-596	178	3	.	.	PUNCT
eurjchem-596	179	1	ir	ir	PROPN
eurjchem-596	179	2	(	(	PUNCT
eurjchem-596	179	3	kbr	kbr	PROPN
eurjchem-596	179	4	,	,	PUNCT
eurjchem-596	179	5	ν	ν	PROPN
eurjchem-596	179	6	,	,	PUNCT
eurjchem-596	179	7	cm–1	cm–1	PROPN
eurjchem-596	179	8	):	):	PUNCT
eurjchem-596	179	9	3340	3340	NUM
eurjchem-596	179	10	,	,	PUNCT
eurjchem-596	179	11	3218	3218	NUM
eurjchem-596	179	12	(	(	PUNCT
eurjchem-596	179	13	nh2	nh2	PROPN
eurjchem-596	179	14	)	)	PUNCT
eurjchem-596	179	15	,	,	PUNCT
eurjchem-596	179	16	3080	3080	NUM
eurjchem-596	179	17	(	(	PUNCT
eurjchem-596	179	18	ch	ch	NOUN
eurjchem-596	179	19	arom	arom	NOUN
eurjchem-596	179	20	.	.	PUNCT
eurjchem-596	179	21	)	)	PUNCT
eurjchem-596	179	22	,	,	PUNCT
eurjchem-596	179	23	2940	2940	NUM
eurjchem-596	179	24	,	,	PUNCT
eurjchem-596	179	25	2872	2872	NUM
eurjchem-596	179	26	(	(	PUNCT
eurjchem-596	179	27	ch	ch	NOUN
eurjchem-596	179	28	aliph	aliph	PROPN
eurjchem-596	179	29	.	.	PUNCT
eurjchem-596	179	30	)	)	PUNCT
eurjchem-596	179	31	,	,	PUNCT
eurjchem-596	179	32	2218	2218	NUM
eurjchem-596	179	33	(	(	PUNCT
eurjchem-596	179	34	c≡n	c≡n	PROPN
eurjchem-596	179	35	)	)	PUNCT
eurjchem-596	179	36	,	,	PUNCT
eurjchem-596	179	37	1658	1658	NUM
eurjchem-596	179	38	(	(	PUNCT
eurjchem-596	179	39	c	c	NOUN
eurjchem-596	179	40	=	=	NOUN
eurjchem-596	179	41	o	o	NOUN
eurjchem-596	179	42	)	)	PUNCT
eurjchem-596	179	43	.	.	PUNCT
eurjchem-596	180	1	1h	1h	NUM
eurjchem-596	180	2	nmr	nmr	NOUN
eurjchem-596	180	3	(	(	PUNCT
eurjchem-596	180	4	300	300	NUM
eurjchem-596	180	5	mhz	mhz	NOUN
eurjchem-596	180	6	,	,	PUNCT
eurjchem-596	180	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	180	8	,	,	PUNCT
eurjchem-596	180	9			NUM
eurjchem-596	180	10	,	,	PUNCT
eurjchem-596	180	11	ppm	ppm	NUM
eurjchem-596	180	12	):	):	PUNCT
eurjchem-596	180	13	1.2	1.2	NUM
eurjchem-596	180	14	(	(	PUNCT
eurjchem-596	180	15	t	t	PROPN
eurjchem-596	180	16	,	,	PUNCT
eurjchem-596	180	17	3h	3h	NUM
eurjchem-596	180	18	,	,	PUNCT
eurjchem-596	180	19	ch3	ch3	PROPN
eurjchem-596	180	20	,	,	PUNCT
eurjchem-596	180	21	j	j	PROPN
eurjchem-596	180	22	=	=	PROPN
eurjchem-596	180	23	0.66	0.66	NUM
eurjchem-596	180	24	hz	hz	NOUN
eurjchem-596	180	25	)	)	PUNCT
eurjchem-596	180	26	,	,	PUNCT
eurjchem-596	180	27	2.6	2.6	NUM
eurjchem-596	180	28	(	(	PUNCT
eurjchem-596	180	29	q	q	NOUN
eurjchem-596	180	30	,	,	PUNCT
eurjchem-596	180	31	2h	2h	NUM
eurjchem-596	180	32	,	,	PUNCT
eurjchem-596	180	33	ch2	ch2	PROPN
eurjchem-596	180	34	,	,	PUNCT
eurjchem-596	180	35	j	j	PROPN
eurjchem-596	180	36	=	=	PROPN
eurjchem-596	180	37	0.66	0.66	NUM
eurjchem-596	180	38	hz	hz	NOUN
eurjchem-596	180	39	)	)	PUNCT
eurjchem-596	180	40	,	,	PUNCT
eurjchem-596	180	41	5.7	5.7	NUM
eurjchem-596	180	42	(	(	PUNCT
eurjchem-596	180	43	s	s	PROPN
eurjchem-596	180	44	,	,	PUNCT
eurjchem-596	180	45	1h	1h	NUM
eurjchem-596	180	46	,	,	PUNCT
eurjchem-596	180	47	ch‐pyridine	ch‐pyridine	NOUN
eurjchem-596	180	48	)	)	PUNCT
eurjchem-596	180	49	,	,	PUNCT
eurjchem-596	180	50	6.9‐7.5	6.9‐7.5	NUM
eurjchem-596	180	51	(	(	PUNCT
eurjchem-596	180	52	m	m	PROPN
eurjchem-596	180	53	,	,	PUNCT
eurjchem-596	180	54	8h	8h	NUM
eurjchem-596	180	55	,	,	PUNCT
eurjchem-596	180	56	ar‐h	ar‐h	PROPN
eurjchem-596	180	57	)	)	PUNCT
eurjchem-596	180	58	,	,	PUNCT
eurjchem-596	180	59	8.7	8.7	NUM
eurjchem-596	180	60	(	(	PUNCT
eurjchem-596	180	61	s	s	PROPN
eurjchem-596	180	62	,	,	PUNCT
eurjchem-596	180	63	2h	2h	NUM
eurjchem-596	180	64	,	,	PUNCT
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eurjchem-596	180	66	,	,	PUNCT
eurjchem-596	180	67	exchangeable	exchangeable	ADJ
eurjchem-596	180	68	with	with	ADP
eurjchem-596	180	69	d2o	d2o	NOUN
eurjchem-596	180	70	)	)	PUNCT
eurjchem-596	180	71	.	.	PUNCT
eurjchem-596	181	1	ms	ms	NOUN
eurjchem-596	181	2	(	(	PUNCT
eurjchem-596	181	3	m	m	PROPN
eurjchem-596	181	4	/	/	SYM
eurjchem-596	181	5	z	z	NOUN
eurjchem-596	181	6	,	,	PUNCT
eurjchem-596	181	7	%	%	INTJ
eurjchem-596	181	8	):	):	PUNCT
eurjchem-596	181	9	424	424	NUM
eurjchem-596	181	10	(	(	PUNCT
eurjchem-596	181	11	m+	m+	NUM
eurjchem-596	181	12	,	,	PUNCT
eurjchem-596	181	13	20.3	20.3	NUM
eurjchem-596	181	14	)	)	PUNCT
eurjchem-596	181	15	,	,	PUNCT
eurjchem-596	181	16	141	141	NUM
eurjchem-596	181	17	(	(	PUNCT
eurjchem-596	181	18	100	100	NUM
eurjchem-596	181	19	)	)	PUNCT
eurjchem-596	181	20	.	.	PUNCT
eurjchem-596	182	1	anal	anal	PROPN
eurjchem-596	182	2	.	.	PUNCT
eurjchem-596	182	3	calcd	calcd	NOUN
eurjchem-596	182	4	.	.	PUNCT
eurjchem-596	183	1	for	for	SCONJ
eurjchem-596	183	2	c25h20n4o3	c25h20n4o3	PROPN
eurjchem-596	183	3	:	:	PUNCT
eurjchem-596	183	4	c	c	X
eurjchem-596	183	5	,	,	PUNCT
eurjchem-596	183	6	70.74	70.74	NUM
eurjchem-596	183	7	;	;	PUNCT
eurjchem-596	183	8	h	h	X
eurjchem-596	183	9	,	,	PUNCT
eurjchem-596	183	10	4.75	4.75	NUM
eurjchem-596	183	11	;	;	PUNCT
eurjchem-596	183	12	n	n	CCONJ
eurjchem-596	183	13	,	,	PUNCT
eurjchem-596	183	14	13.20	13.20	NUM
eurjchem-596	183	15	.	.	PUNCT
eurjchem-596	183	16	found	find	VERB
eurjchem-596	183	17	:	:	PUNCT
eurjchem-596	184	1	c	c	X
eurjchem-596	184	2	,	,	PUNCT
eurjchem-596	184	3	70.50	70.50	NUM
eurjchem-596	184	4	;	;	PUNCT
eurjchem-596	184	5	h	h	NOUN
eurjchem-596	184	6	,	,	PUNCT
eurjchem-596	184	7	4.50	4.50	NUM
eurjchem-596	184	8	;	;	PUNCT
eurjchem-596	184	9	n	n	CCONJ
eurjchem-596	184	10	,	,	PUNCT
eurjchem-596	184	11	13.60	13.60	NUM
eurjchem-596	184	12	%	%	NOUN
eurjchem-596	184	13	.	.	PUNCT
eurjchem-596	185	1	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(2	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(2	NUM
eurjchem-596	185	2	,	,	PUNCT
eurjchem-596	185	3	4	4	NUM
eurjchem-596	185	4	,	,	PUNCT
eurjchem-596	185	5	5‐trimet‐	5‐trimet‐	NUM
eurjchem-596	185	6	hoxyphenyl)‐1,2‐dihydro‐	hoxyphenyl)‐1,2‐dihydro‐	PROPN
eurjchem-596	185	7	isoquinoline‐7‐carbonitrile	isoquinoline‐7‐carbonitrile	NOUN
eurjchem-596	185	8	(	(	PUNCT
eurjchem-596	185	9	6f	6f	NUM
eurjchem-596	185	10	):	):	PUNCT
eurjchem-596	185	11	yield	yield	NOUN
eurjchem-596	185	12	:	:	PUNCT
eurjchem-596	185	13	79	79	NUM
eurjchem-596	185	14	%	%	NOUN
eurjchem-596	185	15	.	.	PUNCT
eurjchem-596	186	1	m.p	m.p	PROPN
eurjchem-596	186	2	.	.	PROPN
eurjchem-596	186	3	:	:	PUNCT
eurjchem-596	186	4	117‐119	117‐119	NUM
eurjchem-596	186	5	c	c	X
eurjchem-596	186	6	.	.	PUNCT
eurjchem-596	187	1	ir	ir	PROPN
eurjchem-596	187	2	(	(	PUNCT
eurjchem-596	187	3	kbr	kbr	PROPN
eurjchem-596	187	4	,	,	PUNCT
eurjchem-596	187	5	ν	ν	PROPN
eurjchem-596	187	6	,	,	PUNCT
eurjchem-596	187	7	cm–1	cm–1	PROPN
eurjchem-596	187	8	):	):	PUNCT
eurjchem-596	187	9	3364	3364	NUM
eurjchem-596	187	10	,	,	PUNCT
eurjchem-596	187	11	3209	3209	NUM
eurjchem-596	187	12	(	(	PUNCT
eurjchem-596	187	13	nh2	nh2	PROPN
eurjchem-596	187	14	)	)	PUNCT
eurjchem-596	187	15	,	,	PUNCT
eurjchem-596	187	16	3080	3080	NUM
eurjchem-596	187	17	(	(	PUNCT
eurjchem-596	187	18	ch	ch	NOUN
eurjchem-596	187	19	arom	arom	NOUN
eurjchem-596	187	20	.	.	PUNCT
eurjchem-596	187	21	)	)	PUNCT
eurjchem-596	187	22	,	,	PUNCT
eurjchem-596	187	23	2931	2931	NUM
eurjchem-596	187	24	,	,	PUNCT
eurjchem-596	187	25	2836	2836	NUM
eurjchem-596	187	26	(	(	PUNCT
eurjchem-596	187	27	ch	ch	NOUN
eurjchem-596	187	28	aliph	aliph	PROPN
eurjchem-596	187	29	.	.	PUNCT
eurjchem-596	187	30	)	)	PUNCT
eurjchem-596	187	31	,	,	PUNCT
eurjchem-596	187	32	2213	2213	NUM
eurjchem-596	187	33	(	(	PUNCT
eurjchem-596	187	34	c≡n	c≡n	PROPN
eurjchem-596	187	35	)	)	PUNCT
eurjchem-596	187	36	,	,	PUNCT
eurjchem-596	187	37	1658	1658	NUM
eurjchem-596	187	38	(	(	PUNCT
eurjchem-596	187	39	c	c	NOUN
eurjchem-596	187	40	=	=	NOUN
eurjchem-596	187	41	o	o	NOUN
eurjchem-596	187	42	)	)	PUNCT
eurjchem-596	187	43	.	.	PUNCT
eurjchem-596	188	1	1h	1h	NUM
eurjchem-596	188	2	nmr	nmr	NOUN
eurjchem-596	188	3	(	(	PUNCT
eurjchem-596	188	4	300	300	NUM
eurjchem-596	188	5	mhz	mhz	NOUN
eurjchem-596	188	6	,	,	PUNCT
eurjchem-596	188	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	188	8	,	,	PUNCT
eurjchem-596	188	9			NUM
eurjchem-596	188	10	,	,	PUNCT
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eurjchem-596	188	12	):	):	PUNCT
eurjchem-596	188	13	1.2	1.2	NUM
eurjchem-596	188	14	(	(	PUNCT
eurjchem-596	188	15	t	t	PROPN
eurjchem-596	188	16	,	,	PUNCT
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eurjchem-596	188	18	,	,	PUNCT
eurjchem-596	188	19	ch3	ch3	PROPN
eurjchem-596	188	20	,	,	PUNCT
eurjchem-596	188	21	j	j	PROPN
eurjchem-596	188	22	=	=	PROPN
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eurjchem-596	188	24	hz	hz	NOUN
eurjchem-596	188	25	)	)	PUNCT
eurjchem-596	188	26	,	,	PUNCT
eurjchem-596	188	27	2.6	2.6	NUM
eurjchem-596	188	28	(	(	PUNCT
eurjchem-596	188	29	q	q	NOUN
eurjchem-596	188	30	,	,	PUNCT
eurjchem-596	188	31	2h	2h	NUM
eurjchem-596	188	32	,	,	PUNCT
eurjchem-596	188	33	ch2	ch2	PROPN
eurjchem-596	188	34	,	,	PUNCT
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eurjchem-596	188	36	=	=	PROPN
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eurjchem-596	188	39	)	)	PUNCT
eurjchem-596	188	40	,	,	PUNCT
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eurjchem-596	188	42	(	(	PUNCT
eurjchem-596	188	43	3s	3s	NOUN
eurjchem-596	188	44	,	,	PUNCT
eurjchem-596	188	45	9h	9h	NUM
eurjchem-596	188	46	,	,	PUNCT
eurjchem-596	188	47	3och3	3och3	NUM
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eurjchem-596	188	49	,	,	PUNCT
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eurjchem-596	188	58	,	,	PUNCT
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eurjchem-596	189	2	(	(	PUNCT
eurjchem-596	189	3	m	m	PROPN
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eurjchem-596	189	6	,	,	PUNCT
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eurjchem-596	189	11	m+	m+	NUM
eurjchem-596	189	12	,	,	PUNCT
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eurjchem-596	189	15	,	,	PUNCT
eurjchem-596	189	16	90	90	NUM
eurjchem-596	189	17	(	(	PUNCT
eurjchem-596	189	18	100	100	NUM
eurjchem-596	189	19	)	)	PUNCT
eurjchem-596	189	20	.	.	PUNCT
eurjchem-596	190	1	anal	anal	PROPN
eurjchem-596	190	2	.	.	PUNCT
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eurjchem-596	190	4	.	.	PUNCT
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eurjchem-596	191	2	c28h27n3o4	c28h27n3o4	PROPN
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eurjchem-596	191	4	c	c	X
eurjchem-596	191	5	,	,	PUNCT
eurjchem-596	191	6	71.62	71.62	NUM
eurjchem-596	191	7	;	;	PUNCT
eurjchem-596	191	8	h	h	NOUN
eurjchem-596	191	9	,	,	PUNCT
eurjchem-596	191	10	5.80	5.80	NUM
eurjchem-596	191	11	;	;	PUNCT
eurjchem-596	191	12	n	n	CCONJ
eurjchem-596	191	13	,	,	PUNCT
eurjchem-596	191	14	8.95	8.95	NUM
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eurjchem-596	191	17	:	:	PUNCT
eurjchem-596	192	1	c	c	X
eurjchem-596	192	2	,	,	PUNCT
eurjchem-596	192	3	71.30	71.30	NUM
eurjchem-596	192	4	;	;	PUNCT
eurjchem-596	192	5	h	h	NOUN
eurjchem-596	192	6	,	,	PUNCT
eurjchem-596	192	7	5.40	5.40	NUM
eurjchem-596	192	8	;	;	PUNCT
eurjchem-596	192	9	n	n	CCONJ
eurjchem-596	192	10	,	,	PUNCT
eurjchem-596	192	11	9.10	9.10	NUM
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eurjchem-596	192	13	.	.	PUNCT
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eurjchem-596	194	1	1,2‐dihydro‐	1,2‐dihydro‐	NUM
eurjchem-596	194	2	isoquinoline‐7‐carbonitrile	isoquinoline‐7‐carbonitrile	NOUN
eurjchem-596	194	3	(	(	PUNCT
eurjchem-596	194	4	6	6	NUM
eurjchem-596	194	5	g	g	NOUN
eurjchem-596	194	6	):	):	PUNCT
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eurjchem-596	194	8	:	:	PUNCT
eurjchem-596	194	9	80	80	NUM
eurjchem-596	194	10	%	%	NOUN
eurjchem-596	194	11	.	.	PUNCT
eurjchem-596	195	1	m.p	m.p	PROPN
eurjchem-596	195	2	.	.	PROPN
eurjchem-596	195	3	:	:	PUNCT
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eurjchem-596	196	3	.	.	PUNCT
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eurjchem-596	197	8	):	):	PUNCT
eurjchem-596	197	9	3370	3370	NUM
eurjchem-596	197	10	,	,	PUNCT
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eurjchem-596	197	12	(	(	PUNCT
eurjchem-596	197	13	nh2	nh2	PROPN
eurjchem-596	197	14	)	)	PUNCT
eurjchem-596	197	15	,	,	PUNCT
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eurjchem-596	197	17	(	(	PUNCT
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eurjchem-596	197	19	arom	arom	NOUN
eurjchem-596	197	20	.	.	PUNCT
eurjchem-596	197	21	)	)	PUNCT
eurjchem-596	197	22	,	,	PUNCT
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eurjchem-596	197	24	,	,	PUNCT
eurjchem-596	197	25	2860	2860	NUM
eurjchem-596	197	26	(	(	PUNCT
eurjchem-596	197	27	ch	ch	NOUN
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eurjchem-596	197	29	.	.	PUNCT
eurjchem-596	197	30	)	)	PUNCT
eurjchem-596	197	31	,	,	PUNCT
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eurjchem-596	197	34	c≡n	c≡n	PROPN
eurjchem-596	197	35	)	)	PUNCT
eurjchem-596	197	36	,	,	PUNCT
eurjchem-596	197	37	1658	1658	NUM
eurjchem-596	197	38	(	(	PUNCT
eurjchem-596	197	39	c	c	NOUN
eurjchem-596	197	40	=	=	NOUN
eurjchem-596	197	41	o	o	NOUN
eurjchem-596	197	42	)	)	PUNCT
eurjchem-596	197	43	.	.	PUNCT
eurjchem-596	198	1	1h	1h	NUM
eurjchem-596	198	2	nmr	nmr	NOUN
eurjchem-596	198	3	(	(	PUNCT
eurjchem-596	198	4	300	300	NUM
eurjchem-596	198	5	mhz	mhz	NOUN
eurjchem-596	198	6	,	,	PUNCT
eurjchem-596	198	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	198	8	,	,	PUNCT
eurjchem-596	198	9			NUM
eurjchem-596	198	10	,	,	PUNCT
eurjchem-596	198	11	ppm	ppm	NUM
eurjchem-596	198	12	):	):	PUNCT
eurjchem-596	198	13	1.2	1.2	NUM
eurjchem-596	198	14	(	(	PUNCT
eurjchem-596	198	15	t	t	PROPN
eurjchem-596	198	16	,	,	PUNCT
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eurjchem-596	198	18	,	,	PUNCT
eurjchem-596	198	19	ch3	ch3	PROPN
eurjchem-596	198	20	,	,	PUNCT
eurjchem-596	198	21	j	j	PROPN
eurjchem-596	198	22	=	=	PROPN
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eurjchem-596	198	24	hz	hz	NOUN
eurjchem-596	198	25	)	)	PUNCT
eurjchem-596	198	26	,	,	PUNCT
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eurjchem-596	198	30	,	,	PUNCT
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eurjchem-596	198	34	,	,	PUNCT
eurjchem-596	198	35	j	j	PROPN
eurjchem-596	198	36	=	=	PROPN
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eurjchem-596	198	39	)	)	PUNCT
eurjchem-596	198	40	,	,	PUNCT
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eurjchem-596	198	46	,	,	PUNCT
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eurjchem-596	198	49	,	,	PUNCT
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eurjchem-596	198	62	,	,	PUNCT
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eurjchem-596	198	71	.	.	PUNCT
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eurjchem-596	199	2	(	(	PUNCT
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eurjchem-596	199	6	,	,	PUNCT
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eurjchem-596	199	8	):	):	PUNCT
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eurjchem-596	199	17	(	(	PUNCT
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eurjchem-596	199	19	)	)	PUNCT
eurjchem-596	199	20	.	.	PUNCT
eurjchem-596	200	1	anal	anal	PROPN
eurjchem-596	200	2	.	.	PUNCT
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eurjchem-596	200	4	.	.	PUNCT
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eurjchem-596	201	4	c	c	X
eurjchem-596	201	5	,	,	PUNCT
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eurjchem-596	201	8	h	h	NOUN
eurjchem-596	201	9	,	,	PUNCT
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eurjchem-596	201	13	,	,	PUNCT
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eurjchem-596	201	15	.	.	PUNCT
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eurjchem-596	202	2	:	:	PUNCT
eurjchem-596	203	1	c	c	X
eurjchem-596	203	2	,	,	PUNCT
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eurjchem-596	203	5	h	h	NOUN
eurjchem-596	203	6	,	,	PUNCT
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eurjchem-596	203	8	;	;	PUNCT
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eurjchem-596	203	10	,	,	PUNCT
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eurjchem-596	203	13	.	.	PUNCT
eurjchem-596	204	1	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(2,4‐dichloro	8‐amino‐2‐(3‐ethylphenyl)‐3‐methyl‐1‐oxo‐6‐(2,4‐dichloro	NUM
eurjchem-596	205	1	phenyl)‐1,2‐dihydro‐	phenyl)‐1,2‐dihydro‐	PROPN
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eurjchem-596	205	4	6h	6h	NUM
eurjchem-596	205	5	):	):	PUNCT
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eurjchem-596	205	7	:	:	PUNCT
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eurjchem-596	206	6	.	.	PUNCT
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eurjchem-596	207	3	kbr	kbr	PROPN
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eurjchem-596	207	8	):	):	PUNCT
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eurjchem-596	207	11	3209	3209	NUM
eurjchem-596	207	12	(	(	PUNCT
eurjchem-596	207	13	nh2	nh2	PROPN
eurjchem-596	207	14	)	)	PUNCT
eurjchem-596	207	15	,	,	PUNCT
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eurjchem-596	207	18	ch	ch	NOUN
eurjchem-596	207	19	arom	arom	NOUN
eurjchem-596	207	20	.	.	PUNCT
eurjchem-596	207	21	)	)	PUNCT
eurjchem-596	207	22	,	,	PUNCT
eurjchem-596	207	23	2930	2930	NUM
eurjchem-596	207	24	,	,	PUNCT
eurjchem-596	207	25	2856(ch	2856(ch	NUM
eurjchem-596	207	26	aliph	aliph	VERB
eurjchem-596	207	27	.	.	PUNCT
eurjchem-596	207	28	)	)	PUNCT
eurjchem-596	207	29	,	,	PUNCT
eurjchem-596	207	30	2198	2198	NUM
eurjchem-596	207	31	(	(	PUNCT
eurjchem-596	207	32	c≡n	c≡n	PROPN
eurjchem-596	207	33	)	)	PUNCT
eurjchem-596	207	34	,	,	PUNCT
eurjchem-596	207	35	1658	1658	NUM
eurjchem-596	207	36	(	(	PUNCT
eurjchem-596	207	37	c	c	NOUN
eurjchem-596	207	38	=	=	NOUN
eurjchem-596	207	39	o	o	NOUN
eurjchem-596	207	40	)	)	PUNCT
eurjchem-596	207	41	.	.	PUNCT
eurjchem-596	208	1	1h	1h	NUM
eurjchem-596	208	2	nmr	nmr	NOUN
eurjchem-596	208	3	(	(	PUNCT
eurjchem-596	208	4	300	300	NUM
eurjchem-596	208	5	mhz	mhz	NOUN
eurjchem-596	208	6	,	,	PUNCT
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eurjchem-596	208	10	,	,	PUNCT
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eurjchem-596	208	12	):	):	PUNCT
eurjchem-596	208	13	1.2	1.2	NUM
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eurjchem-596	208	15	t	t	PROPN
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eurjchem-596	208	18	,	,	PUNCT
eurjchem-596	208	19	ch3	ch3	PROPN
eurjchem-596	208	20	,	,	PUNCT
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eurjchem-596	208	22	=	=	PROPN
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eurjchem-596	208	26	,	,	PUNCT
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eurjchem-596	208	30	,	,	PUNCT
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eurjchem-596	208	36	=	=	PROPN
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eurjchem-596	208	40	,	,	PUNCT
eurjchem-596	208	41	5.7	5.7	NUM
eurjchem-596	208	42	(	(	PUNCT
eurjchem-596	208	43	s	s	PROPN
eurjchem-596	208	44	,	,	PUNCT
eurjchem-596	208	45	1h	1h	NUM
eurjchem-596	208	46	,	,	PUNCT
eurjchem-596	208	47	ch‐pyridine	ch‐pyridine	NOUN
eurjchem-596	208	48	)	)	PUNCT
eurjchem-596	208	49	,	,	PUNCT
eurjchem-596	208	50	6.9‐7.9	6.9‐7.9	NUM
eurjchem-596	208	51	(	(	PUNCT
eurjchem-596	208	52	m	m	PROPN
eurjchem-596	208	53	,	,	PUNCT
eurjchem-596	208	54	7h	7h	PROPN
eurjchem-596	208	55	,	,	PUNCT
eurjchem-596	208	56	ar‐h	ar‐h	PROPN
eurjchem-596	208	57	)	)	PUNCT
eurjchem-596	208	58	,	,	PUNCT
eurjchem-596	208	59	8.7	8.7	NUM
eurjchem-596	208	60	(	(	PUNCT
eurjchem-596	208	61	s	s	PROPN
eurjchem-596	208	62	,	,	PUNCT
eurjchem-596	208	63	2h	2h	NUM
eurjchem-596	208	64	,	,	PUNCT
eurjchem-596	208	65	nh2	nh2	PROPN
eurjchem-596	208	66	,	,	PUNCT
eurjchem-596	208	67	exchangeable	exchangeable	ADJ
eurjchem-596	208	68	with	with	ADP
eurjchem-596	208	69	d2o	d2o	NOUN
eurjchem-596	208	70	)	)	PUNCT
eurjchem-596	208	71	.	.	PUNCT
eurjchem-596	209	1	ms	ms	NOUN
eurjchem-596	209	2	(	(	PUNCT
eurjchem-596	209	3	m	m	PROPN
eurjchem-596	209	4	/	/	SYM
eurjchem-596	209	5	z	z	NOUN
eurjchem-596	209	6	,	,	PUNCT
eurjchem-596	209	7	%	%	INTJ
eurjchem-596	209	8	):	):	PUNCT
eurjchem-596	209	9	448	448	NUM
eurjchem-596	209	10	(	(	PUNCT
eurjchem-596	209	11	m+	m+	NUM
eurjchem-596	209	12	,	,	PUNCT
eurjchem-596	209	13	5.9	5.9	NUM
eurjchem-596	209	14	)	)	PUNCT
eurjchem-596	209	15	,	,	PUNCT
eurjchem-596	209	16	141	141	NUM
eurjchem-596	209	17	(	(	PUNCT
eurjchem-596	209	18	100	100	NUM
eurjchem-596	209	19	)	)	PUNCT
eurjchem-596	209	20	.	.	PUNCT
eurjchem-596	210	1	anal	anal	PROPN
eurjchem-596	210	2	.	.	PUNCT
eurjchem-596	210	3	calcd	calcd	NOUN
eurjchem-596	210	4	.	.	PUNCT
eurjchem-596	211	1	for	for	ADP
eurjchem-596	211	2	c25h20cl2n3o	c25h20cl2n3o	NOUN
eurjchem-596	211	3	:	:	PUNCT
eurjchem-596	211	4	c	c	X
eurjchem-596	211	5	,	,	PUNCT
eurjchem-596	211	6	66.97	66.97	NUM
eurjchem-596	211	7	;	;	PUNCT
eurjchem-596	211	8	h	h	X
eurjchem-596	211	9	,	,	PUNCT
eurjchem-596	211	10	4.27	4.27	NUM
eurjchem-596	211	11	;	;	PUNCT
eurjchem-596	211	12	n	n	CCONJ
eurjchem-596	211	13	,	,	PUNCT
eurjchem-596	211	14	9.37	9.37	NUM
eurjchem-596	211	15	.	.	PUNCT
eurjchem-596	211	16	found	find	VERB
eurjchem-596	211	17	:	:	PUNCT
eurjchem-596	212	1	c	c	X
eurjchem-596	212	2	,	,	PUNCT
eurjchem-596	212	3	66.60	66.60	NUM
eurjchem-596	212	4	;	;	PUNCT
eurjchem-596	212	5	h	h	NOUN
eurjchem-596	212	6	,	,	PUNCT
eurjchem-596	212	7	4.60	4.60	NUM
eurjchem-596	212	8	;	;	PUNCT
eurjchem-596	212	9	n	n	CCONJ
eurjchem-596	212	10	,	,	PUNCT
eurjchem-596	212	11	9.60	9.60	NUM
eurjchem-596	212	12	%	%	NOUN
eurjchem-596	212	13	.	.	PUNCT
eurjchem-596	213	1	2.2.5	2.2.5	X
eurjchem-596	213	2	.	.	X
eurjchem-596	213	3	n‐(3‐ethylphenyl)‐2‐oxo‐2h‐chromene‐3‐carboxamide	n‐(3‐ethylphenyl)‐2‐oxo‐2h‐chromene‐3‐carboxamide	NOUN
eurjchem-596	213	4	(	(	PUNCT
eurjchem-596	213	5	7	7	NUM
eurjchem-596	213	6	)	)	PUNCT
eurjchem-596	213	7	to	to	ADP
eurjchem-596	213	8	a	a	DET
eurjchem-596	213	9	solution	solution	NOUN
eurjchem-596	213	10	of	of	ADP
eurjchem-596	213	11	compound	compound	NOUN
eurjchem-596	213	12	3	3	NUM
eurjchem-596	213	13	(	(	PUNCT
eurjchem-596	213	14	1.88	1.88	NUM
eurjchem-596	213	15	g	g	NOUN
eurjchem-596	213	16	,	,	PUNCT
eurjchem-596	213	17	0.01	0.01	NUM
eurjchem-596	213	18	mol	mol	NOUN
eurjchem-596	213	19	)	)	PUNCT
eurjchem-596	213	20	in	in	ADP
eurjchem-596	213	21	acetic	acetic	ADJ
eurjchem-596	213	22	anhydride	anhydride	NOUN
eurjchem-596	213	23	(	(	PUNCT
eurjchem-596	213	24	20	20	NUM
eurjchem-596	213	25	ml	ml	NOUN
eurjchem-596	213	26	)	)	PUNCT
eurjchem-596	213	27	,	,	PUNCT
eurjchem-596	213	28	salicyladehyde	salicyladehyde	NOUN
eurjchem-596	213	29	(	(	PUNCT
eurjchem-596	213	30	1.22	1.22	NUM
eurjchem-596	213	31	g	g	NOUN
eurjchem-596	213	32	,	,	PUNCT
eurjchem-596	213	33	0.01	0.01	NUM
eurjchem-596	213	34	mol	mol	NOUN
eurjchem-596	213	35	)	)	PUNCT
eurjchem-596	213	36	and	and	CCONJ
eurjchem-596	213	37	fused	fuse	VERB
eurjchem-596	213	38	sodium	sodium	NOUN
eurjchem-596	213	39	acetate	acetate	NOUN
eurjchem-596	213	40	(	(	PUNCT
eurjchem-596	213	41	0.8	0.8	NUM
eurjchem-596	213	42	g	g	NOUN
eurjchem-596	213	43	,	,	PUNCT
eurjchem-596	213	44	0.01	0.01	NUM
eurjchem-596	213	45	mo	mo	NOUN
eurjchem-596	213	46	)	)	PUNCT
eurjchem-596	213	47	was	be	AUX
eurjchem-596	213	48	added	add	VERB
eurjchem-596	213	49	.	.	PUNCT
eurjchem-596	214	1	the	the	DET
eurjchem-596	214	2	reaction	reaction	NOUN
eurjchem-596	214	3	mixture	mixture	NOUN
eurjchem-596	214	4	was	be	AUX
eurjchem-596	214	5	refluxed	refluxe	VERB
eurjchem-596	214	6	for	for	ADP
eurjchem-596	214	7	2	2	NUM
eurjchem-596	214	8	h	h	NOUN
eurjchem-596	214	9	,	,	PUNCT
eurjchem-596	214	10	cooled	cool	VERB
eurjchem-596	214	11	and	and	CCONJ
eurjchem-596	214	12	the	the	DET
eurjchem-596	214	13	solid	solid	ADJ
eurjchem-596	214	14	obtained	obtain	VERB
eurjchem-596	214	15	was	be	AUX
eurjchem-596	214	16	crystallized	crystallize	VERB
eurjchem-596	214	17	from	from	ADP
eurjchem-596	214	18	ethanol	ethanol	NOUN
eurjchem-596	214	19	to	to	PART
eurjchem-596	214	20	give	give	VERB
eurjchem-596	214	21	compound	compound	NOUN
eurjchem-596	214	22	7	7	NUM
eurjchem-596	214	23	(	(	PUNCT
eurjchem-596	214	24	scheme	scheme	NOUN
eurjchem-596	214	25	3	3	NUM
eurjchem-596	214	26	)	)	PUNCT
eurjchem-596	214	27	.	.	PUNCT
eurjchem-596	215	1	yield	yield	NOUN
eurjchem-596	215	2	:	:	PUNCT
eurjchem-596	215	3	69	69	NUM
eurjchem-596	215	4	%	%	NOUN
eurjchem-596	215	5	.	.	PUNCT
eurjchem-596	216	1	m.p	m.p	PROPN
eurjchem-596	216	2	.	.	PROPN
eurjchem-596	216	3	:	:	PUNCT
eurjchem-596	216	4	117‐119	117‐119	NUM
eurjchem-596	216	5	c	c	X
eurjchem-596	216	6	.	.	PUNCT
eurjchem-596	217	1	ir	ir	PROPN
eurjchem-596	217	2	(	(	PUNCT
eurjchem-596	217	3	kbr	kbr	PROPN
eurjchem-596	217	4	,	,	PUNCT
eurjchem-596	217	5	ν	ν	PROPN
eurjchem-596	217	6	,	,	PUNCT
eurjchem-596	217	7	cm–1	cm–1	PROPN
eurjchem-596	217	8	):	):	PUNCT
eurjchem-596	217	9	3417(nh	3417(nh	NUM
eurjchem-596	217	10	)	)	PUNCT
eurjchem-596	217	11	,	,	PUNCT
eurjchem-596	217	12	1766	1766	NUM
eurjchem-596	217	13	(	(	PUNCT
eurjchem-596	217	14	2c	2c	NOUN
eurjchem-596	217	15	=	=	SYM
eurjchem-596	217	16	o	o	NOUN
eurjchem-596	217	17	)	)	PUNCT
eurjchem-596	217	18	.	.	PUNCT
eurjchem-596	218	1	1h	1h	NUM
eurjchem-596	218	2	nmr	nmr	NOUN
eurjchem-596	218	3	(	(	PUNCT
eurjchem-596	218	4	300	300	NUM
eurjchem-596	218	5	mhz	mhz	NOUN
eurjchem-596	218	6	,	,	PUNCT
eurjchem-596	218	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	218	8	,	,	PUNCT
eurjchem-596	218	9			NUM
eurjchem-596	218	10	,	,	PUNCT
eurjchem-596	218	11	ppm	ppm	NUM
eurjchem-596	218	12	):	):	PUNCT
eurjchem-596	218	13	1.3	1.3	NUM
eurjchem-596	218	14	(	(	PUNCT
eurjchem-596	218	15	t	t	PROPN
eurjchem-596	218	16	,	,	PUNCT
eurjchem-596	218	17	3h	3h	NUM
eurjchem-596	218	18	,	,	PUNCT
eurjchem-596	218	19	ch3	ch3	PROPN
eurjchem-596	218	20	,	,	PUNCT
eurjchem-596	218	21	j	j	PROPN
eurjchem-596	218	22	=	=	NOUN
eurjchem-596	218	23	0.2	0.2	NUM
eurjchem-596	218	24	hz	hz	NOUN
eurjchem-596	218	25	)	)	PUNCT
eurjchem-596	218	26	2.6	2.6	NUM
eurjchem-596	218	27	(	(	PUNCT
eurjchem-596	218	28	q	q	NOUN
eurjchem-596	218	29	,	,	PUNCT
eurjchem-596	218	30	2h	2h	NUM
eurjchem-596	218	31	,	,	PUNCT
eurjchem-596	218	32	ch2	ch2	PROPN
eurjchem-596	218	33	,	,	PUNCT
eurjchem-596	218	34	j	j	PROPN
eurjchem-596	219	1	=	=	PUNCT
eurjchem-596	219	2	0.2	0.2	NUM
eurjchem-596	219	3	hz	hz	NOUN
eurjchem-596	219	4	)	)	PUNCT
eurjchem-596	219	5	,	,	PUNCT
eurjchem-596	219	6	7.3‐8.0	7.3‐8.0	X
eurjchem-596	219	7	(	(	PUNCT
eurjchem-596	219	8	m	m	PROPN
eurjchem-596	219	9	,	,	PUNCT
eurjchem-596	219	10	8h	8h	NUM
eurjchem-596	219	11	,	,	PUNCT
eurjchem-596	219	12	ar‐h	ar‐h	PROPN
eurjchem-596	219	13	)	)	PUNCT
eurjchem-596	219	14	,	,	PUNCT
eurjchem-596	219	15	8.35	8.35	NUM
eurjchem-596	219	16	(	(	PUNCT
eurjchem-596	219	17	s	s	PROPN
eurjchem-596	219	18	,	,	PUNCT
eurjchem-596	219	19	1h	1h	NUM
eurjchem-596	219	20	,	,	PUNCT
eurjchem-596	219	21	ch	ch	NOUN
eurjchem-596	219	22	)	)	PUNCT
eurjchem-596	219	23	,	,	PUNCT
eurjchem-596	219	24	8.42	8.42	NUM
eurjchem-596	219	25	(	(	PUNCT
eurjchem-596	219	26	s	s	PROPN
eurjchem-596	219	27	,	,	PUNCT
eurjchem-596	219	28	1h	1h	NUM
eurjchem-596	219	29	,	,	PUNCT
eurjchem-596	219	30	nh	nh	PROPN
eurjchem-596	219	31	,	,	PUNCT
eurjchem-596	219	32	exchangeable	exchangeable	ADJ
eurjchem-596	219	33	with	with	ADP
eurjchem-596	219	34	d2o	d2o	NOUN
eurjchem-596	219	35	)	)	PUNCT
eurjchem-596	219	36	.	.	PUNCT
eurjchem-596	220	1	13c	13c	NOUN
eurjchem-596	220	2	nmr	nmr	NOUN
eurjchem-596	220	3	(	(	PUNCT
eurjchem-596	220	4	75	75	NUM
eurjchem-596	220	5	mhz	mhz	NOUN
eurjchem-596	220	6	,	,	PUNCT
eurjchem-596	220	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	220	8	,	,	PUNCT
eurjchem-596	220	9			NUM
eurjchem-596	220	10	,	,	PUNCT
eurjchem-596	220	11	ppm	ppm	NUM
eurjchem-596	220	12	):	):	PUNCT
eurjchem-596	220	13	14.1	14.1	NUM
eurjchem-596	220	14	,	,	PUNCT
eurjchem-596	220	15	30.2	30.2	NUM
eurjchem-596	220	16	,	,	PUNCT
eurjchem-596	220	17	113.6	113.6	NUM
eurjchem-596	220	18	,	,	PUNCT
eurjchem-596	220	19	117.5	117.5	NUM
eurjchem-596	220	20	,	,	PUNCT
eurjchem-596	220	21	119.8	119.8	NUM
eurjchem-596	220	22	,	,	PUNCT
eurjchem-596	220	23	122.7	122.7	NUM
eurjchem-596	220	24	,	,	PUNCT
eurjchem-596	220	25	124.2	124.2	NUM
eurjchem-596	220	26	,	,	PUNCT
eurjchem-596	220	27	125.6	125.6	NUM
eurjchem-596	220	28	,	,	PUNCT
eurjchem-596	220	29	127.0	127.0	NUM
eurjchem-596	220	30	,	,	PUNCT
eurjchem-596	220	31	127.9	127.9	NUM
eurjchem-596	220	32	,	,	PUNCT
eurjchem-596	220	33	129.6	129.6	NUM
eurjchem-596	220	34	,	,	PUNCT
eurjchem-596	220	35	130.2	130.2	NUM
eurjchem-596	220	36	,	,	PUNCT
eurjchem-596	220	37	133.5	133.5	NUM
eurjchem-596	220	38	,	,	PUNCT
eurjchem-596	220	39	136.1	136.1	NUM
eurjchem-596	220	40	,	,	PUNCT
eurjchem-596	220	41	140.2	140.2	NUM
eurjchem-596	220	42	,	,	PUNCT
eurjchem-596	220	43	153.6	153.6	NUM
eurjchem-596	220	44	,	,	PUNCT
eurjchem-596	220	45	161.2	161.2	NUM
eurjchem-596	220	46	,	,	PUNCT
eurjchem-596	220	47	164.3	164.3	NUM
eurjchem-596	220	48	.	.	PUNCT
eurjchem-596	220	49	anal	anal	PROPN
eurjchem-596	220	50	.	.	PUNCT
eurjchem-596	220	51	calcd	calcd	NOUN
eurjchem-596	220	52	.	.	PUNCT
eurjchem-596	221	1	for	for	ADP
eurjchem-596	221	2	c18h15no3	c18h15no3	PROPN
eurjchem-596	221	3	:	:	PUNCT
eurjchem-596	221	4	c	c	X
eurjchem-596	221	5	,	,	PUNCT
eurjchem-596	221	6	73.71	73.71	NUM
eurjchem-596	221	7	;	;	PUNCT
eurjchem-596	221	8	h	h	NOUN
eurjchem-596	221	9	,	,	PUNCT
eurjchem-596	221	10	5.15	5.15	NUM
eurjchem-596	221	11	;	;	PUNCT
eurjchem-596	221	12	n	n	CCONJ
eurjchem-596	221	13	,	,	PUNCT
eurjchem-596	221	14	4.78	4.78	NUM
eurjchem-596	221	15	.	.	PUNCT
eurjchem-596	221	16	found	find	VERB
eurjchem-596	221	17	:	:	PUNCT
eurjchem-596	222	1	c	c	X
eurjchem-596	222	2	,	,	PUNCT
eurjchem-596	222	3	73.60	73.60	NUM
eurjchem-596	222	4	;	;	PUNCT
eurjchem-596	222	5	h	h	NOUN
eurjchem-596	222	6	,	,	PUNCT
eurjchem-596	222	7	5.70	5.70	NUM
eurjchem-596	222	8	;	;	PUNCT
eurjchem-596	222	9	n	n	CCONJ
eurjchem-596	222	10	,	,	PUNCT
eurjchem-596	222	11	4.50	4.50	NUM
eurjchem-596	222	12	%	%	NOUN
eurjchem-596	222	13	.	.	PUNCT
eurjchem-596	223	1	2.2.6	2.2.6	X
eurjchem-596	223	2	.	.	PUNCT
eurjchem-596	223	3	n‐(3‐ethylphenyl)‐2‐imino‐2h‐chromene‐3‐	n‐(3‐ethylphenyl)‐2‐imino‐2h‐chromene‐3‐	VERB
eurjchem-596	223	4	carboxamide	carboxamide	NOUN
eurjchem-596	223	5	(	(	PUNCT
eurjchem-596	223	6	8)	8)	NUM
eurjchem-596	223	7	a	a	DET
eurjchem-596	223	8	mixture	mixture	NOUN
eurjchem-596	223	9	of	of	ADP
eurjchem-596	223	10	compound	compound	NOUN
eurjchem-596	223	11	3	3	NUM
eurjchem-596	223	12	(	(	PUNCT
eurjchem-596	223	13	1.88	1.88	NUM
eurjchem-596	223	14	g	g	NOUN
eurjchem-596	223	15	,	,	PUNCT
eurjchem-596	223	16	0.01	0.01	NUM
eurjchem-596	223	17	mol	mol	NOUN
eurjchem-596	223	18	)	)	PUNCT
eurjchem-596	223	19	,	,	PUNCT
eurjchem-596	223	20	salicyladehyde	salicyladehyde	NOUN
eurjchem-596	223	21	(	(	PUNCT
eurjchem-596	223	22	1.22	1.22	NUM
eurjchem-596	223	23	g	g	NOUN
eurjchem-596	223	24	,	,	PUNCT
eurjchem-596	223	25	0.01	0.01	NUM
eurjchem-596	223	26	mol	mol	NOUN
eurjchem-596	223	27	)	)	PUNCT
eurjchem-596	223	28	and	and	CCONJ
eurjchem-596	223	29	anhydrous	anhydrous	ADJ
eurjchem-596	223	30	ammonium	ammonium	NOUN
eurjchem-596	223	31	acetate	acetate	NOUN
eurjchem-596	223	32	(	(	PUNCT
eurjchem-596	223	33	1.15	1.15	NUM
eurjchem-596	223	34	g	g	NOUN
eurjchem-596	223	35	,	,	PUNCT
eurjchem-596	223	36	0.15	0.15	NUM
eurjchem-596	223	37	mol	mol	NOUN
eurjchem-596	223	38	)	)	PUNCT
eurjchem-596	223	39	in	in	ADP
eurjchem-596	223	40	ethanol	ethanol	NOUN
eurjchem-596	223	41	(	(	PUNCT
eurjchem-596	223	42	20	20	NUM
eurjchem-596	223	43	ml	ml	NOUN
eurjchem-596	223	44	)	)	PUNCT
eurjchem-596	223	45	was	be	AUX
eurjchem-596	223	46	refluxed	refluxe	VERB
eurjchem-596	223	47	for	for	ADP
eurjchem-596	223	48	2	2	NUM
eurjchem-596	223	49	h.	h.	NOUN
eurjchem-596	223	50	the	the	DET
eurjchem-596	223	51	solid	solid	ADJ
eurjchem-596	223	52	obtained	obtain	VERB
eurjchem-596	223	53	was	be	AUX
eurjchem-596	223	54	recrystallized	recrystallize	VERB
eurjchem-596	223	55	from	from	ADP
eurjchem-596	223	56	ethanol	ethanol	NOUN
eurjchem-596	223	57	to	to	PART
eurjchem-596	223	58	give	give	VERB
eurjchem-596	223	59	compound	compound	NOUN
eurjchem-596	223	60	8	8	NUM
eurjchem-596	223	61	(	(	PUNCT
eurjchem-596	223	62	scheme	scheme	NOUN
eurjchem-596	223	63	3	3	NUM
eurjchem-596	223	64	)	)	PUNCT
eurjchem-596	223	65	.	.	PUNCT
eurjchem-596	224	1	yield	yield	NOUN
eurjchem-596	224	2	:	:	PUNCT
eurjchem-596	224	3	59	59	NUM
eurjchem-596	224	4	%	%	NOUN
eurjchem-596	224	5	.	.	PUNCT
eurjchem-596	225	1	m.p	m.p	PROPN
eurjchem-596	225	2	.	.	PROPN
eurjchem-596	225	3	:	:	PUNCT
eurjchem-596	226	1	>	>	PUNCT
eurjchem-596	226	2	300	300	NUM
eurjchem-596	226	3	c	c	VERB
eurjchem-596	226	4	.	.	PUNCT
eurjchem-596	227	1	ir	ir	PROPN
eurjchem-596	227	2	(	(	PUNCT
eurjchem-596	227	3	kbr	kbr	PROPN
eurjchem-596	227	4	,	,	PUNCT
eurjchem-596	227	5	ν	ν	PROPN
eurjchem-596	227	6	,	,	PUNCT
eurjchem-596	227	7	cm–1	cm–1	PROPN
eurjchem-596	227	8	):	):	PUNCT
eurjchem-596	227	9	3344	3344	NUM
eurjchem-596	227	10	,	,	PUNCT
eurjchem-596	227	11	3166	3166	NUM
eurjchem-596	227	12	(	(	PUNCT
eurjchem-596	227	13	2nh	2nh	NOUN
eurjchem-596	227	14	)	)	PUNCT
eurjchem-596	227	15	,	,	PUNCT
eurjchem-596	227	16	1720	1720	NUM
eurjchem-596	227	17	(	(	PUNCT
eurjchem-596	227	18	c	c	NOUN
eurjchem-596	227	19	=	=	NOUN
eurjchem-596	227	20	o	o	NOUN
eurjchem-596	227	21	)	)	PUNCT
eurjchem-596	227	22	,	,	PUNCT
eurjchem-596	227	23	1570	1570	NUM
eurjchem-596	227	24	(	(	PUNCT
eurjchem-596	227	25	c	c	NOUN
eurjchem-596	227	26	=	=	SYM
eurjchem-596	227	27	n	n	NUM
eurjchem-596	227	28	)	)	PUNCT
eurjchem-596	227	29	.	.	PUNCT
eurjchem-596	228	1	1h	1h	NUM
eurjchem-596	228	2	nmr	nmr	NOUN
eurjchem-596	228	3	(	(	PUNCT
eurjchem-596	228	4	300	300	NUM
eurjchem-596	228	5	mhz	mhz	NOUN
eurjchem-596	228	6	,	,	PUNCT
eurjchem-596	228	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	228	8	,	,	PUNCT
eurjchem-596	228	9			NUM
eurjchem-596	228	10	,	,	PUNCT
eurjchem-596	228	11	ppm	ppm	NUM
eurjchem-596	228	12	):	):	PUNCT
eurjchem-596	228	13	1.1	1.1	NUM
eurjchem-596	228	14	(	(	PUNCT
eurjchem-596	228	15	t	t	PROPN
eurjchem-596	228	16	,	,	PUNCT
eurjchem-596	228	17	3h	3h	NUM
eurjchem-596	228	18	,	,	PUNCT
eurjchem-596	228	19	ch3	ch3	PROPN
eurjchem-596	228	20	,	,	PUNCT
eurjchem-596	228	21	j	j	PROPN
eurjchem-596	228	22	=	=	NOUN
eurjchem-596	228	23	0.2	0.2	NUM
eurjchem-596	228	24	hz	hz	NOUN
eurjchem-596	228	25	)	)	PUNCT
eurjchem-596	228	26	2.7	2.7	NUM
eurjchem-596	228	27	(	(	PUNCT
eurjchem-596	228	28	q	q	NOUN
eurjchem-596	228	29	,	,	PUNCT
eurjchem-596	228	30	2h	2h	NUM
eurjchem-596	228	31	,	,	PUNCT
eurjchem-596	228	32	ch2	ch2	PROPN
eurjchem-596	228	33	,	,	PUNCT
eurjchem-596	228	34	j	j	PROPN
eurjchem-596	228	35	=	=	PUNCT
eurjchem-596	228	36	0.2	0.2	NUM
eurjchem-596	228	37	hz	hz	NOUN
eurjchem-596	228	38	)	)	PUNCT
eurjchem-596	228	39	,	,	PUNCT
eurjchem-596	228	40	6.9‐8.3	6.9‐8.3	NUM
eurjchem-596	228	41	(	(	PUNCT
eurjchem-596	228	42	m	m	PROPN
eurjchem-596	228	43	,	,	PUNCT
eurjchem-596	228	44	8h	8h	NUM
eurjchem-596	228	45	,	,	PUNCT
eurjchem-596	228	46	ar‐h	ar‐h	PROPN
eurjchem-596	228	47	)	)	PUNCT
eurjchem-596	228	48	,	,	PUNCT
eurjchem-596	228	49	8.7	8.7	NUM
eurjchem-596	228	50	(	(	PUNCT
eurjchem-596	228	51	s	s	PROPN
eurjchem-596	228	52	,	,	PUNCT
eurjchem-596	228	53	1h	1h	NUM
eurjchem-596	228	54	,	,	PUNCT
eurjchem-596	228	55	ch‐4	ch‐4	NOUN
eurjchem-596	228	56	)	)	PUNCT
eurjchem-596	228	57	,	,	PUNCT
eurjchem-596	228	58	9.5	9.5	NUM
eurjchem-596	228	59	(	(	PUNCT
eurjchem-596	228	60	s	s	PROPN
eurjchem-596	228	61	,	,	PUNCT
eurjchem-596	228	62	1h	1h	NUM
eurjchem-596	228	63	,	,	PUNCT
eurjchem-596	228	64	nh	nh	NOUN
eurjchem-596	228	65	imino	imino	NOUN
eurjchem-596	228	66	,	,	PUNCT
eurjchem-596	228	67	exchangeable	exchangeable	ADJ
eurjchem-596	228	68	with	with	ADP
eurjchem-596	228	69	d2o	d2o	NOUN
eurjchem-596	228	70	)	)	PUNCT
eurjchem-596	228	71	,	,	PUNCT
eurjchem-596	228	72	12.5	12.5	NUM
eurjchem-596	228	73	(	(	PUNCT
eurjchem-596	228	74	s	s	PROPN
eurjchem-596	228	75	,	,	PUNCT
eurjchem-596	228	76	1h	1h	NUM
eurjchem-596	228	77	,	,	PUNCT
eurjchem-596	228	78	nhco	nhco	ADJ
eurjchem-596	228	79	,	,	PUNCT
eurjchem-596	228	80	exchangeable	exchangeable	ADJ
eurjchem-596	228	81	with	with	ADP
eurjchem-596	228	82	d2o	d2o	NOUN
eurjchem-596	228	83	)	)	PUNCT
eurjchem-596	228	84	.	.	PUNCT
eurjchem-596	229	1	13c	13c	NOUN
eurjchem-596	229	2	nmr	nmr	NOUN
eurjchem-596	229	3	(	(	PUNCT
eurjchem-596	229	4	75	75	NUM
eurjchem-596	229	5	mhz	mhz	NOUN
eurjchem-596	229	6	,	,	PUNCT
eurjchem-596	229	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	229	8	,	,	PUNCT
eurjchem-596	229	9			NUM
eurjchem-596	229	10	,	,	PUNCT
eurjchem-596	229	11	ppm	ppm	NUM
eurjchem-596	229	12	):	):	PUNCT
eurjchem-596	229	13	13.4	13.4	NUM
eurjchem-596	229	14	,	,	PUNCT
eurjchem-596	229	15	31.2	31.2	NUM
eurjchem-596	229	16	,	,	PUNCT
eurjchem-596	229	17	114.6	114.6	NUM
eurjchem-596	229	18	,	,	PUNCT
eurjchem-596	229	19	115.8	115.8	NUM
eurjchem-596	229	20	,	,	PUNCT
eurjchem-596	229	21	117.1	117.1	NUM
eurjchem-596	229	22	,	,	PUNCT
eurjchem-596	229	23	119.8	119.8	NUM
eurjchem-596	229	24	,	,	PUNCT
eurjchem-596	229	25	122.6	122.6	NUM
eurjchem-596	229	26	,	,	PUNCT
eurjchem-596	229	27	123.3	123.3	NUM
eurjchem-596	229	28	,	,	PUNCT
eurjchem-596	229	29	124.7	124.7	NUM
eurjchem-596	229	30	,	,	PUNCT
eurjchem-596	229	31	126.2	126.2	NUM
eurjchem-596	229	32	,	,	PUNCT
eurjchem-596	229	33	127.5	127.5	NUM
eurjchem-596	229	34	,	,	PUNCT
eurjchem-596	229	35	128.7	128.7	NUM
eurjchem-596	229	36	,	,	PUNCT
eurjchem-596	229	37	130.6	130.6	NUM
eurjchem-596	229	38	,	,	PUNCT
eurjchem-596	229	39	133.8	133.8	NUM
eurjchem-596	229	40	,	,	PUNCT
eurjchem-596	229	41	137.1	137.1	NUM
eurjchem-596	229	42	,	,	PUNCT
eurjchem-596	229	43	152.9	152.9	NUM
eurjchem-596	229	44	,	,	PUNCT
eurjchem-596	229	45	162.7	162.7	NUM
eurjchem-596	229	46	,	,	PUNCT
eurjchem-596	229	47	171.3	171.3	NUM
eurjchem-596	229	48	.	.	PUNCT
eurjchem-596	229	49	anal	anal	PROPN
eurjchem-596	229	50	.	.	PUNCT
eurjchem-596	229	51	calcd	calcd	NOUN
eurjchem-596	229	52	.	.	PUNCT
eurjchem-596	230	1	for	for	ADP
eurjchem-596	230	2	c18h16n2o2	c18h16n2o2	NOUN
eurjchem-596	230	3	:	:	PUNCT
eurjchem-596	230	4	c	c	X
eurjchem-596	230	5	,	,	PUNCT
eurjchem-596	230	6	73.95	73.95	NUM
eurjchem-596	230	7	;	;	PUNCT
eurjchem-596	230	8	h	h	NOUN
eurjchem-596	230	9	,	,	PUNCT
eurjchem-596	230	10	5.52	5.52	NUM
eurjchem-596	230	11	,	,	PUNCT
eurjchem-596	230	12	n	n	CCONJ
eurjchem-596	230	13	,	,	PUNCT
eurjchem-596	230	14	9.58	9.58	NUM
eurjchem-596	230	15	.	.	PUNCT
eurjchem-596	230	16	found	find	VERB
eurjchem-596	230	17	:	:	PUNCT
eurjchem-596	231	1	c	c	X
eurjchem-596	231	2	,	,	PUNCT
eurjchem-596	231	3	73.60	73.60	NUM
eurjchem-596	231	4	;	;	PUNCT
eurjchem-596	231	5	h	h	NOUN
eurjchem-596	231	6	,	,	PUNCT
eurjchem-596	231	7	5.20	5.20	NUM
eurjchem-596	231	8	;	;	PUNCT
eurjchem-596	231	9	n	n	CCONJ
eurjchem-596	231	10	,	,	PUNCT
eurjchem-596	231	11	9.30	9.30	NUM
eurjchem-596	231	12	%	%	NOUN
eurjchem-596	231	13	.	.	PUNCT
eurjchem-596	232	1	232	232	NUM
eurjchem-596	232	2	al‐said	al‐said	PROPN
eurjchem-596	232	3	et	et	PROPN
eurjchem-596	232	4	al	al	PROPN
eurjchem-596	232	5	.	.	PUNCT
eurjchem-596	232	6	/	/	SYM
eurjchem-596	232	7	european	european	PROPN
eurjchem-596	232	8	journal	journal	PROPN
eurjchem-596	232	9	of	of	ADP
eurjchem-596	232	10	chemistry	chemistry	NOUN
eurjchem-596	232	11	3	3	NUM
eurjchem-596	232	12	(	(	PUNCT
eurjchem-596	232	13	2	2	NUM
eurjchem-596	232	14	)	)	PUNCT
eurjchem-596	232	15	(	(	PUNCT
eurjchem-596	232	16	2012	2012	NUM
eurjchem-596	232	17	)	)	PUNCT
eurjchem-596	232	18	228‐234	228‐234	PROPN
eurjchem-596	232	19	2.2.7	2.2.7	NUM
eurjchem-596	232	20	.	.	PUNCT
eurjchem-596	233	1	2‐amino‐3‐(3‐ethylphenyl)‐4,5‐dioxo‐4,5‐dihydro‐3h‐	2‐amino‐3‐(3‐ethylphenyl)‐4,5‐dioxo‐4,5‐dihydro‐3h‐	NUM
eurjchem-596	233	2	chromeno(3,4‐c)pyridine‐1‐carbonitrile	chromeno(3,4‐c)pyridine‐1‐carbonitrile	ADJ
eurjchem-596	233	3	(	(	PUNCT
eurjchem-596	233	4	9	9	NUM
eurjchem-596	233	5	)	)	PUNCT
eurjchem-596	233	6	and	and	CCONJ
eurjchem-596	233	7	2‐amino‐3‐	2‐amino‐3‐	NUM
eurjchem-596	233	8	(	(	PUNCT
eurjchem-596	233	9	3‐ethylphenyl)‐5‐imino‐4‐oxo‐4,5‐dihydro‐3h‐chromeno	3‐ethylphenyl)‐5‐imino‐4‐oxo‐4,5‐dihydro‐3h‐chromeno	NUM
eurjchem-596	233	10	(	(	PUNCT
eurjchem-596	233	11	3,4‐c)pyridine‐1‐carbonitrile	3,4‐c)pyridine‐1‐carbonitrile	NUM
eurjchem-596	233	12	(	(	PUNCT
eurjchem-596	233	13	10	10	NUM
eurjchem-596	233	14	)	)	PUNCT
eurjchem-596	233	15	equimolar	equimolar	NOUN
eurjchem-596	233	16	amounts	amount	NOUN
eurjchem-596	233	17	of	of	ADP
eurjchem-596	233	18	compounds	compound	NOUN
eurjchem-596	233	19	7	7	NUM
eurjchem-596	233	20	or	or	CCONJ
eurjchem-596	233	21	8	8	NUM
eurjchem-596	233	22	,	,	PUNCT
eurjchem-596	233	23	malononitrile	malononitrile	NOUN
eurjchem-596	233	24	(	(	PUNCT
eurjchem-596	233	25	0.66	0.66	NUM
eurjchem-596	233	26	g	g	NOUN
eurjchem-596	233	27	,	,	PUNCT
eurjchem-596	233	28	0.01mol	0.01mol	NUM
eurjchem-596	233	29	)	)	PUNCT
eurjchem-596	233	30	anhydrous	anhydrous	ADJ
eurjchem-596	233	31	ammonium	ammonium	NOUN
eurjchem-596	233	32	acetate	acetate	NOUN
eurjchem-596	233	33	(	(	PUNCT
eurjchem-596	233	34	1.115	1.115	NUM
eurjchem-596	233	35	g	g	NOUN
eurjchem-596	233	36	,	,	PUNCT
eurjchem-596	233	37	0.01	0.01	NUM
eurjchem-596	233	38	mol	mol	NOUN
eurjchem-596	233	39	)	)	PUNCT
eurjchem-596	233	40	in	in	ADP
eurjchem-596	233	41	ethanol	ethanol	NOUN
eurjchem-596	233	42	were	be	AUX
eurjchem-596	233	43	refluxed	refluxe	VERB
eurjchem-596	233	44	for	for	ADP
eurjchem-596	233	45	4	4	NUM
eurjchem-596	233	46	h.	h.	NOUN
eurjchem-596	233	47	the	the	DET
eurjchem-596	233	48	solid	solid	ADJ
eurjchem-596	233	49	obtained	obtain	VERB
eurjchem-596	233	50	by	by	ADP
eurjchem-596	233	51	filtration	filtration	NOUN
eurjchem-596	233	52	was	be	AUX
eurjchem-596	233	53	recrystallized	recrystallize	VERB
eurjchem-596	233	54	from	from	ADP
eurjchem-596	233	55	dioxane	dioxane	NOUN
eurjchem-596	233	56	to	to	PART
eurjchem-596	233	57	give	give	VERB
eurjchem-596	233	58	compound	compound	NOUN
eurjchem-596	233	59	9	9	NUM
eurjchem-596	233	60	and	and	CCONJ
eurjchem-596	233	61	10	10	NUM
eurjchem-596	233	62	,	,	PUNCT
eurjchem-596	233	63	(	(	PUNCT
eurjchem-596	233	64	scheme	scheme	NOUN
eurjchem-596	233	65	3	3	NUM
eurjchem-596	233	66	)	)	PUNCT
eurjchem-596	233	67	respectively	respectively	ADV
eurjchem-596	233	68	.	.	PUNCT
eurjchem-596	234	1	2‐amino‐3‐(3‐ethylphenyl)‐4,5‐dioxo‐4,5‐dihydro‐3h‐	2‐amino‐3‐(3‐ethylphenyl)‐4,5‐dioxo‐4,5‐dihydro‐3h‐	NUM
eurjchem-596	234	2	chromeno(3,4‐c)pyridine‐1‐carbonitrile	chromeno(3,4‐c)pyridine‐1‐carbonitrile	ADJ
eurjchem-596	234	3	(	(	PUNCT
eurjchem-596	234	4	9	9	NUM
eurjchem-596	234	5	):	):	PUNCT
eurjchem-596	234	6	yield	yield	NOUN
eurjchem-596	234	7	:	:	PUNCT
eurjchem-596	234	8	61	61	NUM
eurjchem-596	234	9	%	%	NOUN
eurjchem-596	234	10	.	.	PUNCT
eurjchem-596	235	1	m.p	m.p	PROPN
eurjchem-596	235	2	.	.	PROPN
eurjchem-596	235	3	:	:	PUNCT
eurjchem-596	236	1	>	>	PUNCT
eurjchem-596	236	2	300	300	NUM
eurjchem-596	236	3	c	c	VERB
eurjchem-596	236	4	.	.	PUNCT
eurjchem-596	237	1	ir	ir	PROPN
eurjchem-596	237	2	(	(	PUNCT
eurjchem-596	237	3	kbr	kbr	PROPN
eurjchem-596	237	4	,	,	PUNCT
eurjchem-596	237	5	ν	ν	PROPN
eurjchem-596	237	6	,	,	PUNCT
eurjchem-596	237	7	cm–1	cm–1	PROPN
eurjchem-596	237	8	):	):	PUNCT
eurjchem-596	237	9	3090	3090	NUM
eurjchem-596	237	10	(	(	PUNCT
eurjchem-596	237	11	ch	ch	NOUN
eurjchem-596	237	12	arom	arom	NOUN
eurjchem-596	237	13	.	.	PUNCT
eurjchem-596	237	14	)	)	PUNCT
eurjchem-596	237	15	,	,	PUNCT
eurjchem-596	237	16	2976	2976	NUM
eurjchem-596	237	17	,	,	PUNCT
eurjchem-596	237	18	2865	2865	NUM
eurjchem-596	237	19	(	(	PUNCT
eurjchem-596	237	20	ch	ch	NOUN
eurjchem-596	237	21	aliph	aliph	PROPN
eurjchem-596	237	22	.	.	PUNCT
eurjchem-596	237	23	)	)	PUNCT
eurjchem-596	237	24	,	,	PUNCT
eurjchem-596	237	25	1684	1684	NUM
eurjchem-596	237	26	,	,	PUNCT
eurjchem-596	237	27	1654	1654	NUM
eurjchem-596	237	28	(	(	PUNCT
eurjchem-596	237	29	2c	2c	NOUN
eurjchem-596	237	30	=	=	SYM
eurjchem-596	237	31	o	o	NOUN
eurjchem-596	237	32	)	)	PUNCT
eurjchem-596	237	33	.	.	PUNCT
eurjchem-596	238	1	1h	1h	NUM
eurjchem-596	238	2	nmr	nmr	NOUN
eurjchem-596	238	3	(	(	PUNCT
eurjchem-596	238	4	300	300	NUM
eurjchem-596	238	5	mhz	mhz	NOUN
eurjchem-596	238	6	,	,	PUNCT
eurjchem-596	238	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	238	8	,	,	PUNCT
eurjchem-596	238	9			NUM
eurjchem-596	238	10	,	,	PUNCT
eurjchem-596	238	11	ppm	ppm	NUM
eurjchem-596	238	12	):	):	PUNCT
eurjchem-596	238	13	1.2	1.2	NUM
eurjchem-596	238	14	(	(	PUNCT
eurjchem-596	238	15	t	t	PROPN
eurjchem-596	238	16	,	,	PUNCT
eurjchem-596	238	17	3h	3h	NUM
eurjchem-596	238	18	,	,	PUNCT
eurjchem-596	238	19	ch3	ch3	PROPN
eurjchem-596	238	20	,	,	PUNCT
eurjchem-596	238	21	j	j	PROPN
eurjchem-596	238	22	=	=	PROPN
eurjchem-596	238	23	0.66	0.66	NUM
eurjchem-596	238	24	hz	hz	NOUN
eurjchem-596	238	25	)	)	PUNCT
eurjchem-596	238	26	,	,	PUNCT
eurjchem-596	238	27	2.6	2.6	NUM
eurjchem-596	238	28	(	(	PUNCT
eurjchem-596	238	29	q	q	NOUN
eurjchem-596	238	30	,	,	PUNCT
eurjchem-596	238	31	2h	2h	NUM
eurjchem-596	238	32	,	,	PUNCT
eurjchem-596	238	33	ch2	ch2	PROPN
eurjchem-596	238	34	,	,	PUNCT
eurjchem-596	238	35	j	j	PROPN
eurjchem-596	238	36	=	=	PROPN
eurjchem-596	238	37	0.66	0.66	NUM
eurjchem-596	238	38	hz	hz	NOUN
eurjchem-596	238	39	)	)	PUNCT
eurjchem-596	238	40	,	,	PUNCT
eurjchem-596	238	41	6.9‐7.5	6.9‐7.5	NUM
eurjchem-596	238	42	(	(	PUNCT
eurjchem-596	238	43	m	m	PROPN
eurjchem-596	238	44	,	,	PUNCT
eurjchem-596	238	45	8h	8h	NUM
eurjchem-596	238	46	,	,	PUNCT
eurjchem-596	238	47	ar‐h	ar‐h	PROPN
eurjchem-596	238	48	)	)	PUNCT
eurjchem-596	238	49	.	.	PUNCT
eurjchem-596	239	1	13c	13c	NOUN
eurjchem-596	239	2	nmr	nmr	NOUN
eurjchem-596	239	3	(	(	PUNCT
eurjchem-596	239	4	75	75	NUM
eurjchem-596	239	5	mhz	mhz	NOUN
eurjchem-596	239	6	,	,	PUNCT
eurjchem-596	239	7	dmso‐d6	dmso‐d6	NOUN
eurjchem-596	239	8	,	,	PUNCT
eurjchem-596	239	9			NUM
eurjchem-596	239	10	,	,	PUNCT
eurjchem-596	239	11	ppm	ppm	NUM
eurjchem-596	239	12	):	):	PUNCT
eurjchem-596	239	13	15.8	15.8	NUM
eurjchem-596	239	14	,	,	PUNCT
eurjchem-596	239	15	34.3	34.3	NUM
eurjchem-596	239	16	,	,	PUNCT
eurjchem-596	239	17	73.9	73.9	NUM
eurjchem-596	239	18	,	,	PUNCT
eurjchem-596	239	19	116.5	116.5	NUM
eurjchem-596	239	20	,	,	PUNCT
eurjchem-596	239	21	117.9	117.9	NUM
eurjchem-596	239	22	,	,	PUNCT
eurjchem-596	239	23	118.0	118.0	NUM
eurjchem-596	239	24	,	,	PUNCT
eurjchem-596	239	25	119.2	119.2	NUM
eurjchem-596	239	26	,	,	PUNCT
eurjchem-596	239	27	122.6	122.6	NUM
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eurjchem-596	240	19	)	)	PUNCT
eurjchem-596	240	20	.	.	PUNCT
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eurjchem-596	241	4	.	.	PUNCT
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eurjchem-596	242	4	c	c	X
eurjchem-596	242	5	,	,	PUNCT
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eurjchem-596	242	8	h	h	X
eurjchem-596	242	9	,	,	PUNCT
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eurjchem-596	242	11	;	;	PUNCT
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eurjchem-596	242	13	,	,	PUNCT
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eurjchem-596	242	17	:	:	PUNCT
eurjchem-596	243	1	c	c	X
eurjchem-596	243	2	,	,	PUNCT
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eurjchem-596	243	5	h	h	NOUN
eurjchem-596	243	6	,	,	PUNCT
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eurjchem-596	243	8	;	;	PUNCT
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eurjchem-596	243	12	.	.	NOUN
eurjchem-596	243	13	2‐amino‐3‐(3‐ethylphenyl)‐5‐imino‐4‐oxo‐4,5‐dihydro‐3h‐	2‐amino‐3‐(3‐ethylphenyl)‐5‐imino‐4‐oxo‐4,5‐dihydro‐3h‐	NUM
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eurjchem-596	243	16	10	10	NUM
eurjchem-596	243	17	):	):	PUNCT
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eurjchem-596	243	19	:	:	PUNCT
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eurjchem-596	243	22	.	.	PUNCT
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eurjchem-596	245	1	>	>	PUNCT
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eurjchem-596	245	4	.	.	PUNCT
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eurjchem-596	246	3	kbr	kbr	PROPN
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eurjchem-596	246	12	,	,	PUNCT
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eurjchem-596	246	14	(	(	PUNCT
eurjchem-596	246	15	nh	nh	PROPN
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eurjchem-596	246	17	nh2	nh2	PROPN
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eurjchem-596	246	19	,	,	PUNCT
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eurjchem-596	246	22	.	.	PUNCT
eurjchem-596	246	23	)	)	PUNCT
eurjchem-596	246	24	,	,	PUNCT
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eurjchem-596	246	26	,	,	PUNCT
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eurjchem-596	246	31	.	.	PUNCT
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eurjchem-596	246	35	=	=	SYM
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eurjchem-596	246	38	.	.	PUNCT
eurjchem-596	247	1	1h	1h	NUM
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eurjchem-596	247	3	(	(	PUNCT
eurjchem-596	247	4	300	300	NUM
eurjchem-596	247	5	mhz	mhz	NOUN
eurjchem-596	247	6	,	,	PUNCT
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eurjchem-596	247	8	,	,	PUNCT
eurjchem-596	247	9			NUM
eurjchem-596	247	10	,	,	PUNCT
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eurjchem-596	247	12	):	):	PUNCT
eurjchem-596	247	13	1.2[t	1.2[t	NUM
eurjchem-596	247	14	,	,	PUNCT
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eurjchem-596	247	16	,	,	PUNCT
eurjchem-596	247	17	ch3	ch3	PROPN
eurjchem-596	247	18	,	,	PUNCT
eurjchem-596	247	19	j	j	PROPN
eurjchem-596	247	20	=	=	PROPN
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eurjchem-596	247	22	hz	hz	NOUN
eurjchem-596	247	23	)	)	PUNCT
eurjchem-596	247	24	,	,	PUNCT
eurjchem-596	247	25	2.6	2.6	NUM
eurjchem-596	247	26	(	(	PUNCT
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eurjchem-596	247	28	,	,	PUNCT
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eurjchem-596	247	30	,	,	PUNCT
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eurjchem-596	247	32	,	,	PUNCT
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eurjchem-596	247	34	=	=	PROPN
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eurjchem-596	247	36	hz	hz	NOUN
eurjchem-596	247	37	)	)	PUNCT
eurjchem-596	247	38	,	,	PUNCT
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eurjchem-596	247	40	(	(	PUNCT
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eurjchem-596	247	42	,	,	PUNCT
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eurjchem-596	247	44	,	,	PUNCT
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eurjchem-596	247	46	)	)	PUNCT
eurjchem-596	247	47	,	,	PUNCT
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eurjchem-596	247	49	(	(	PUNCT
eurjchem-596	247	50	s	s	PROPN
eurjchem-596	247	51	,	,	PUNCT
eurjchem-596	247	52	1h	1h	NUM
eurjchem-596	247	53	,	,	PUNCT
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eurjchem-596	247	55	,	,	PUNCT
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eurjchem-596	247	57	with	with	ADP
eurjchem-596	247	58	d2o	d2o	NOUN
eurjchem-596	247	59	)	)	PUNCT
eurjchem-596	247	60	,	,	PUNCT
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eurjchem-596	247	72	)	)	PUNCT
eurjchem-596	247	73	.	.	PUNCT
eurjchem-596	248	1	ms	ms	NOUN
eurjchem-596	248	2	(	(	PUNCT
eurjchem-596	248	3	m	m	PROPN
eurjchem-596	248	4	/	/	SYM
eurjchem-596	248	5	z	z	NOUN
eurjchem-596	248	6	,	,	PUNCT
eurjchem-596	248	7	%	%	INTJ
eurjchem-596	248	8	):	):	PUNCT
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eurjchem-596	248	11	m+	m+	NUM
eurjchem-596	248	12	,	,	PUNCT
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eurjchem-596	248	15	,	,	PUNCT
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eurjchem-596	248	17	(	(	PUNCT
eurjchem-596	248	18	100	100	NUM
eurjchem-596	248	19	)	)	PUNCT
eurjchem-596	248	20	.	.	PUNCT
eurjchem-596	249	1	anal	anal	PROPN
eurjchem-596	249	2	.	.	PUNCT
eurjchem-596	249	3	calcd	calcd	NOUN
eurjchem-596	249	4	.	.	PUNCT
eurjchem-596	250	1	for	for	ADP
eurjchem-596	250	2	c21h16n4o2	c21h16n4o2	PROPN
eurjchem-596	250	3	:	:	PUNCT
eurjchem-596	250	4	c	c	X
eurjchem-596	250	5	,	,	PUNCT
eurjchem-596	250	6	70.77	70.77	NUM
eurjchem-596	250	7	;	;	PUNCT
eurjchem-596	250	8	h	h	NOUN
eurjchem-596	250	9	,	,	PUNCT
eurjchem-596	250	10	4.53	4.53	NUM
eurjchem-596	250	11	;	;	PUNCT
eurjchem-596	250	12	n	n	CCONJ
eurjchem-596	250	13	,	,	PUNCT
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eurjchem-596	250	15	.	.	PUNCT
eurjchem-596	250	16	found	find	VERB
eurjchem-596	250	17	:	:	PUNCT
eurjchem-596	251	1	c	c	X
eurjchem-596	251	2	,	,	PUNCT
eurjchem-596	251	3	75.50	75.50	NUM
eurjchem-596	251	4	;	;	PUNCT
eurjchem-596	251	5	h	h	NOUN
eurjchem-596	251	6	,	,	PUNCT
eurjchem-596	251	7	5.43	5.43	NUM
eurjchem-596	251	8	;	;	PUNCT
eurjchem-596	251	9	n	n	CCONJ
eurjchem-596	251	10	,	,	PUNCT
eurjchem-596	251	11	8.40	8.40	NUM
eurjchem-596	251	12	.	.	NOUN
eurjchem-596	251	13	2.3	2.3	NUM
eurjchem-596	251	14	.	.	PUNCT
eurjchem-596	252	1	in‐vitro	in‐vitro	NOUN
eurjchem-596	252	2	anticancer	anticancer	NOUN
eurjchem-596	252	3	screening	screen	VERB
eurjchem-596	252	4	2.3.1	2.3.1	NUM
eurjchem-596	252	5	.	.	PUNCT
eurjchem-596	252	6	animals	animal	NOUN
eurjchem-596	252	7	,	,	PUNCT
eurjchem-596	252	8	chemicals	chemical	NOUN
eurjchem-596	252	9	and	and	CCONJ
eurjchem-596	252	10	facilities	facility	NOUN
eurjchem-596	252	11	ehrlich	ehrlich	NOUN
eurjchem-596	252	12	ascites	ascite	VERB
eurjchem-596	252	13	carcinoma	carcinoma	NOUN
eurjchem-596	252	14	cells	cell	NOUN
eurjchem-596	252	15	(	(	PUNCT
eurjchem-596	252	16	eac	eac	PROPN
eurjchem-596	252	17	)	)	PUNCT
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eurjchem-596	252	20	in	in	ADP
eurjchem-596	252	21	female	female	ADJ
eurjchem-596	252	22	swiss	swiss	ADJ
eurjchem-596	252	23	albino	albino	NOUN
eurjchem-596	252	24	mice	mouse	NOUN
eurjchem-596	252	25	weighing	weigh	VERB
eurjchem-596	252	26	25‐30	25‐30	NOUN
eurjchem-596	252	27	g	g	PROPN
eurjchem-596	252	28	(	(	PUNCT
eurjchem-596	252	29	the	the	DET
eurjchem-596	252	30	holding	hold	VERB
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eurjchem-596	252	32	for	for	ADP
eurjchem-596	252	33	biological	biological	ADJ
eurjchem-596	252	34	products	product	NOUN
eurjchem-596	252	35	and	and	CCONJ
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eurjchem-596	252	37	,	,	PUNCT
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eurjchem-596	252	39	,	,	PUNCT
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eurjchem-596	252	41	,	,	PUNCT
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eurjchem-596	252	43	)	)	PUNCT
eurjchem-596	252	44	were	be	AUX
eurjchem-596	252	45	housed	house	VERB
eurjchem-596	252	46	at	at	ADP
eurjchem-596	252	47	a	a	DET
eurjchem-596	252	48	constant	constant	ADJ
eurjchem-596	252	49	temperature	temperature	NOUN
eurjchem-596	252	50	(	(	PUNCT
eurjchem-596	252	51	24	24	NUM
eurjchem-596	252	52	°	°	NOUN
eurjchem-596	252	53	c	c	NOUN
eurjchem-596	252	54	)	)	PUNCT
eurjchem-596	252	55	with	with	ADP
eurjchem-596	252	56	alternating	alternate	VERB
eurjchem-596	252	57	12	12	NUM
eurjchem-596	252	58	h	h	NOUN
eurjchem-596	252	59	light	light	NOUN
eurjchem-596	252	60	and	and	CCONJ
eurjchem-596	252	61	dark	dark	ADJ
eurjchem-596	252	62	cycles	cycle	NOUN
eurjchem-596	252	63	and	and	CCONJ
eurjchem-596	252	64	fed	feed	VERB
eurjchem-596	252	65	standard	standard	ADJ
eurjchem-596	252	66	laboratory	laboratory	NOUN
eurjchem-596	252	67	food	food	NOUN
eurjchem-596	252	68	(	(	PUNCT
eurjchem-596	252	69	milad	milad	PROPN
eurjchem-596	252	70	co.	co.	PROPN
eurjchem-596	252	71	,	,	PUNCT
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eurjchem-596	252	75	)	)	PUNCT
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eurjchem-596	252	78	ad	ad	NOUN
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eurjchem-596	252	80	.	.	PUNCT
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eurjchem-596	253	2	chemicals	chemical	NOUN
eurjchem-596	253	3	and	and	CCONJ
eurjchem-596	253	4	reagents	reagent	NOUN
eurjchem-596	253	5	were	be	AUX
eurjchem-596	253	6	of	of	ADP
eurjchem-596	253	7	the	the	DET
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eurjchem-596	253	9	grade	grade	NOUN
eurjchem-596	253	10	commercially	commercially	ADV
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eurjchem-596	253	12	.	.	PUNCT
eurjchem-596	254	1	facilities	facility	NOUN
eurjchem-596	254	2	including	include	VERB
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eurjchem-596	254	5	,	,	PUNCT
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eurjchem-596	254	10	made	make	VERB
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eurjchem-596	254	21	(	(	PUNCT
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eurjchem-596	254	23	)	)	PUNCT
eurjchem-596	254	24	,	,	PUNCT
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eurjchem-596	254	30	)	)	PUNCT
eurjchem-596	254	31	,	,	PUNCT
eurjchem-596	254	32	cairo	cairo	PROPN
eurjchem-596	254	33	,	,	PUNCT
eurjchem-596	254	34	egypt	egypt	PROPN
eurjchem-596	254	35	.	.	PUNCT
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eurjchem-596	255	2	care	care	NOUN
eurjchem-596	255	3	and	and	CCONJ
eurjchem-596	255	4	handling	handling	NOUN
eurjchem-596	255	5	was	be	AUX
eurjchem-596	255	6	done	do	VERB
eurjchem-596	255	7	according	accord	VERB
eurjchem-596	255	8	to	to	ADP
eurjchem-596	255	9	the	the	DET
eurjchem-596	255	10	guidelines	guideline	NOUN
eurjchem-596	255	11	set	set	VERB
eurjchem-596	255	12	by	by	ADP
eurjchem-596	255	13	the	the	DET
eurjchem-596	255	14	world	world	PROPN
eurjchem-596	255	15	health	health	PROPN
eurjchem-596	255	16	organization	organization	PROPN
eurjchem-596	255	17	,	,	PUNCT
eurjchem-596	255	18	geneva	geneva	PROPN
eurjchem-596	255	19	,	,	PUNCT
eurjchem-596	255	20	switzerland	switzerland	PROPN
eurjchem-596	255	21	and	and	CCONJ
eurjchem-596	255	22	approved	approve	VERB
eurjchem-596	255	23	from	from	ADP
eurjchem-596	255	24	the	the	DET
eurjchem-596	255	25	committee	committee	NOUN
eurjchem-596	255	26	for	for	ADP
eurjchem-596	255	27	animals	animal	NOUN
eurjchem-596	255	28	care	care	VERB
eurjchem-596	255	29	at	at	ADP
eurjchem-596	255	30	ncrrt	ncrrt	NOUN
eurjchem-596	255	31	.	.	PUNCT
eurjchem-596	256	1	2.3.4	2.3.4	X
eurjchem-596	256	2	.	.	NOUN
eurjchem-596	256	3	in‐vitro	in‐vitro	NOUN
eurjchem-596	256	4	anticancer	anticancer	NOUN
eurjchem-596	256	5	activity	activity	NOUN
eurjchem-596	256	6	using	use	VERB
eurjchem-596	256	7	ehrlich	ehrlich	PROPN
eurjchem-596	256	8	ascites	ascite	NOUN
eurjchem-596	256	9	carcinoma	carcinoma	NOUN
eurjchem-596	256	10	(	(	PUNCT
eurjchem-596	256	11	eac	eac	PROPN
eurjchem-596	256	12	)	)	PUNCT
eurjchem-596	256	13	cells	cells	PROPN
eurjchem-596	256	14	ehrlich	ehrlich	NOUN
eurjchem-596	256	15	ascites	ascite	VERB
eurjchem-596	256	16	carcinoma	carcinoma	NOUN
eurjchem-596	256	17	cells	cell	NOUN
eurjchem-596	256	18	(	(	PUNCT
eurjchem-596	256	19	eac	eac	PROPN
eurjchem-596	256	20	)	)	PUNCT
eurjchem-596	256	21	were	be	AUX
eurjchem-596	256	22	obtained	obtain	VERB
eurjchem-596	256	23	by	by	ADP
eurjchem-596	256	24	needle	needle	NOUN
eurjchem-596	256	25	aspiration	aspiration	NOUN
eurjchem-596	256	26	of	of	ADP
eurjchem-596	256	27	aseptic	aseptic	ADJ
eurjchem-596	256	28	fluid	fluid	NOUN
eurjchem-596	256	29	from	from	ADP
eurjchem-596	256	30	preinoculated	preinoculate	VERB
eurjchem-596	256	31	mice	mouse	NOUN
eurjchem-596	256	32	;	;	PUNCT
eurjchem-596	256	33	under	under	ADP
eurjchem-596	256	34	aseptic	aseptic	ADJ
eurjchem-596	256	35	conditions	condition	NOUN
eurjchem-596	256	36	.	.	PUNCT
eurjchem-596	257	1	tumor	tumor	NOUN
eurjchem-596	257	2	cells	cell	NOUN
eurjchem-596	257	3	suspension	suspension	NOUN
eurjchem-596	257	4	(	(	PUNCT
eurjchem-596	257	5	2.5x106	2.5x106	NOUN
eurjchem-596	257	6	per	per	ADP
eurjchem-596	257	7	ml	ml	NOUN
eurjchem-596	257	8	)	)	PUNCT
eurjchem-596	257	9	was	be	AUX
eurjchem-596	257	10	prepared	prepare	VERB
eurjchem-596	257	11	in	in	ADP
eurjchem-596	257	12	rpmi‐1640	rpmi‐1640	ADJ
eurjchem-596	257	13	media	medium	NOUN
eurjchem-596	257	14	.	.	PUNCT
eurjchem-596	258	1	tested	test	VERB
eurjchem-596	258	2	compounds	compound	NOUN
eurjchem-596	258	3	were	be	AUX
eurjchem-596	258	4	prepared	prepare	VERB
eurjchem-596	258	5	with	with	ADP
eurjchem-596	258	6	various	various	ADJ
eurjchem-596	258	7	dilutions	dilution	NOUN
eurjchem-596	258	8	by	by	ADP
eurjchem-596	258	9	dissolving	dissolve	VERB
eurjchem-596	258	10	:	:	PUNCT
eurjchem-596	258	11	100	100	NUM
eurjchem-596	258	12	,	,	PUNCT
eurjchem-596	258	13	50	50	NUM
eurjchem-596	258	14	,	,	PUNCT
eurjchem-596	258	15	25	25	NUM
eurjchem-596	258	16	and	and	CCONJ
eurjchem-596	258	17	10	10	NUM
eurjchem-596	258	18	mg	mg	NOUN
eurjchem-596	258	19	of	of	ADP
eurjchem-596	258	20	the	the	DET
eurjchem-596	258	21	tested	test	VERB
eurjchem-596	258	22	compounds	compound	NOUN
eurjchem-596	258	23	in	in	ADP
eurjchem-596	258	24	dmso	dmso	NOUN
eurjchem-596	258	25	(	(	PUNCT
eurjchem-596	258	26	1	1	NUM
eurjchem-596	258	27	ml	ml	NOUN
eurjchem-596	258	28	)	)	PUNCT
eurjchem-596	258	29	.	.	PUNCT
eurjchem-596	259	1	in	in	ADP
eurjchem-596	259	2	a	a	DET
eurjchem-596	259	3	set	set	NOUN
eurjchem-596	259	4	of	of	ADP
eurjchem-596	259	5	sterile	sterile	ADJ
eurjchem-596	259	6	test	test	NOUN
eurjchem-596	259	7	tubes	tube	NOUN
eurjchem-596	259	8	0.8	0.8	NUM
eurjchem-596	259	9	ml	ml	NOUN
eurjchem-596	259	10	rpmi‐1640	rpmi‐1640	PROPN
eurjchem-596	259	11	media	medium	NOUN
eurjchem-596	259	12	containing	contain	VERB
eurjchem-596	259	13	(	(	PUNCT
eurjchem-596	259	14	glutamine	glutamine	NOUN
eurjchem-596	259	15	,	,	PUNCT
eurjchem-596	259	16	fetal	fetal	ADJ
eurjchem-596	259	17	calf	calf	NOUN
eurjchem-596	259	18	serum	serum	NOUN
eurjchem-596	259	19	as	as	ADP
eurjchem-596	259	20	nutrient	nutrient	NOUN
eurjchem-596	259	21	,	,	PUNCT
eurjchem-596	259	22	streptomycin	streptomycin	PROPN
eurjchem-596	259	23	and	and	CCONJ
eurjchem-596	259	24	penicillin	penicillin	PROPN
eurjchem-596	259	25	)	)	PUNCT
eurjchem-596	259	26	,	,	PUNCT
eurjchem-596	259	27	0.1	0.1	NUM
eurjchem-596	259	28	ml	ml	NOUN
eurjchem-596	259	29	of	of	ADP
eurjchem-596	259	30	each	each	PRON
eurjchem-596	259	31	of	of	ADP
eurjchem-596	259	32	the	the	DET
eurjchem-596	259	33	tested	test	VERB
eurjchem-596	259	34	compounds	compound	NOUN
eurjchem-596	259	35	(	(	PUNCT
eurjchem-596	259	36	corresponding	correspond	VERB
eurjchem-596	259	37	to	to	ADP
eurjchem-596	259	38	100	100	NUM
eurjchem-596	259	39	,	,	PUNCT
eurjchem-596	259	40	50	50	NUM
eurjchem-596	259	41	,	,	PUNCT
eurjchem-596	259	42	25	25	NUM
eurjchem-596	259	43	and	and	CCONJ
eurjchem-596	259	44	10	10	NUM
eurjchem-596	259	45	mg	mg	NUM
eurjchem-596	259	46	)	)	PUNCT
eurjchem-596	259	47	were	be	AUX
eurjchem-596	259	48	mixed	mix	VERB
eurjchem-596	259	49	then	then	ADV
eurjchem-596	259	50	0.1	0.1	NUM
eurjchem-596	259	51	ml	ml	NOUN
eurjchem-596	259	52	of	of	ADP
eurjchem-596	259	53	tumor	tumor	NOUN
eurjchem-596	259	54	cell	cell	NOUN
eurjchem-596	259	55	suspension	suspension	NOUN
eurjchem-596	259	56	(	(	PUNCT
eurjchem-596	259	57	2x106	2x106	NUM
eurjchem-596	259	58	)	)	PUNCT
eurjchem-596	259	59	was	be	AUX
eurjchem-596	259	60	added	add	VERB
eurjchem-596	259	61	.	.	PUNCT
eurjchem-596	260	1	the	the	DET
eurjchem-596	260	2	test	test	NOUN
eurjchem-596	260	3	tubes	tube	NOUN
eurjchem-596	260	4	were	be	AUX
eurjchem-596	260	5	incubated	incubate	VERB
eurjchem-596	260	6	at	at	ADP
eurjchem-596	260	7	37	37	NUM
eurjchem-596	260	8	°	°	NOUN
eurjchem-596	260	9	c	c	NOUN
eurjchem-596	260	10	for	for	ADP
eurjchem-596	260	11	2	2	NUM
eurjchem-596	260	12	h.	h.	NOUN
eurjchem-596	260	13	trypan	trypan	NOUN
eurjchem-596	260	14	blue	blue	ADJ
eurjchem-596	260	15	exclusion	exclusion	NOUN
eurjchem-596	260	16	test	test	NOUN
eurjchem-596	260	17	was	be	AUX
eurjchem-596	260	18	carried	carry	VERB
eurjchem-596	260	19	out	out	ADP
eurjchem-596	260	20	to	to	PART
eurjchem-596	260	21	calculate	calculate	VERB
eurjchem-596	260	22	the	the	DET
eurjchem-596	260	23	percentage	percentage	NOUN
eurjchem-596	260	24	of	of	ADP
eurjchem-596	260	25	non‐viable	non‐viable	ADJ
eurjchem-596	260	26	cells	cell	NOUN
eurjchem-596	260	27	after	after	ADP
eurjchem-596	260	28	2	2	NUM
eurjchem-596	260	29	h	h	NOUN
eurjchem-596	260	30	of	of	ADP
eurjchem-596	260	31	incubation	incubation	NOUN
eurjchem-596	261	1	[	[	X
eurjchem-596	261	2	17	17	NUM
eurjchem-596	261	3	]	]	PUNCT
eurjchem-596	261	4	.	.	PUNCT
eurjchem-596	262	1	the	the	DET
eurjchem-596	262	2	total	total	ADJ
eurjchem-596	262	3	number	number	NOUN
eurjchem-596	262	4	of	of	ADP
eurjchem-596	262	5	cells	cell	NOUN
eurjchem-596	262	6	/	/	SYM
eurjchem-596	262	7	ml	ml	NOUN
eurjchem-596	262	8	will	will	AUX
eurjchem-596	262	9	be	be	AUX
eurjchem-596	262	10	determined	determine	VERB
eurjchem-596	262	11	using	use	VERB
eurjchem-596	262	12	the	the	DET
eurjchem-596	262	13	following	follow	VERB
eurjchem-596	262	14	calculations	calculation	NOUN
eurjchem-596	262	15	:	:	PUNCT
eurjchem-596	262	16	cells	cell	NOUN
eurjchem-596	262	17	/	/	SYM
eurjchem-596	262	18	ml	ml	NOUN
eurjchem-596	263	1	=	=	SYM
eurjchem-596	263	2	average	average	ADJ
eurjchem-596	263	3	cells	cell	NOUN
eurjchem-596	263	4	count	count	VERB
eurjchem-596	263	5	per	per	ADP
eurjchem-596	263	6	5	5	NUM
eurjchem-596	263	7	squares	square	NOUN
eurjchem-596	263	8	x	x	NOUN
eurjchem-596	263	9	dilution	dilution	NOUN
eurjchem-596	263	10	factor	factor	NOUN
eurjchem-596	263	11	x	x	NOUN
eurjchem-596	263	12	104	104	NUM
eurjchem-596	263	13	(	(	PUNCT
eurjchem-596	263	14	1	1	NUM
eurjchem-596	263	15	)	)	PUNCT
eurjchem-596	263	16	total	total	ADJ
eurjchem-596	263	17	cells	cell	NOUN
eurjchem-596	263	18	=	=	PUNCT
eurjchem-596	263	19	cells	cell	NOUN
eurjchem-596	263	20	/	/	SYM
eurjchem-596	263	21	ml	ml	ADP
eurjchem-596	263	22	x	x	NOUN
eurjchem-596	263	23	the	the	DET
eurjchem-596	263	24	original	original	ADJ
eurjchem-596	263	25	volume	volume	NOUN
eurjchem-596	263	26	of	of	ADP
eurjchem-596	263	27	fluid	fluid	NOUN
eurjchem-596	263	28	from	from	ADP
eurjchem-596	263	29	which	which	PRON
eurjchem-596	263	30	the	the	DET
eurjchem-596	263	31	cell	cell	NOUN
eurjchem-596	263	32	sample	sample	NOUN
eurjchem-596	263	33	was	be	AUX
eurjchem-596	263	34	removed	remove	VERB
eurjchem-596	263	35	(	(	PUNCT
eurjchem-596	263	36	2	2	NUM
eurjchem-596	263	37	)	)	PUNCT
eurjchem-596	263	38	%	%	NOUN
eurjchem-596	263	39	cell	cell	NOUN
eurjchem-596	263	40	non‐viability	non‐viability	NOUN
eurjchem-596	263	41	=	=	PUNCT
eurjchem-596	263	42	total	total	ADJ
eurjchem-596	263	43	non‐viable	non‐viable	ADJ
eurjchem-596	263	44	cells	cell	NOUN
eurjchem-596	263	45	(	(	PUNCT
eurjchem-596	263	46	stained	stain	VERB
eurjchem-596	263	47	)	)	PUNCT
eurjchem-596	263	48	/	/	SYM
eurjchem-596	263	49	total	total	ADJ
eurjchem-596	263	50	cells	cell	NOUN
eurjchem-596	263	51	x	x	SYM
eurjchem-596	263	52	100	100	NUM
eurjchem-596	263	53	(	(	PUNCT
eurjchem-596	263	54	3	3	X
eurjchem-596	263	55	)	)	PUNCT
eurjchem-596	263	56	the	the	DET
eurjchem-596	263	57	results	result	NOUN
eurjchem-596	263	58	of	of	ADP
eurjchem-596	263	59	in‐vitro	in‐vitro	ADJ
eurjchem-596	263	60	anticancer	anticancer	NOUN
eurjchem-596	263	61	activity	activity	NOUN
eurjchem-596	263	62	experiments	experiment	NOUN
eurjchem-596	263	63	are	be	AUX
eurjchem-596	263	64	presented	present	VERB
eurjchem-596	263	65	in	in	ADP
eurjchem-596	263	66	(	(	PUNCT
eurjchem-596	263	67	table	table	NOUN
eurjchem-596	263	68	1	1	NUM
eurjchem-596	263	69	)	)	PUNCT
eurjchem-596	263	70	.	.	PUNCT
eurjchem-596	264	1	table	table	NOUN
eurjchem-596	264	2	1	1	NUM
eurjchem-596	264	3	.	.	PUNCT
eurjchem-596	264	4	in‐vitro	in‐vitro	NOUN
eurjchem-596	264	5	anticancer	anticancer	NOUN
eurjchem-596	264	6	screening	screening	NOUN
eurjchem-596	264	7	of	of	ADP
eurjchem-596	264	8	the	the	DET
eurjchem-596	264	9	newly	newly	ADV
eurjchem-596	264	10	synthesized	synthesize	VERB
eurjchem-596	264	11	compounds	compound	NOUN
eurjchem-596	264	12	against	against	ADP
eurjchem-596	264	13	ehrlich	ehrlich	NOUN
eurjchem-596	264	14	ascites	ascite	NOUN
eurjchem-596	264	15	carcinoma	carcinoma	ADJ
eurjchem-596	264	16	tumor	tumor	NOUN
eurjchem-596	264	17	cells	cell	NOUN
eurjchem-596	264	18	(	(	PUNCT
eurjchem-596	264	19	eac	eac	PROPN
eurjchem-596	264	20	)	)	PUNCT
eurjchem-596	264	21	.	.	PUNCT
eurjchem-596	265	1	compound	compound	VERB
eurjchem-596	265	2	no	no	DET
eurjchem-596	265	3	non‐viable	non‐viable	ADJ
eurjchem-596	265	4	cells	cell	NOUN
eurjchem-596	265	5	(	(	PUNCT
eurjchem-596	265	6	%	%	INTJ
eurjchem-596	265	7	)	)	PUNCT
eurjchem-596	266	1	ic50	ic50	PROPN
eurjchem-596	266	2	a	a	DET
eurjchem-596	266	3	(	(	PUNCT
eurjchem-596	266	4	µg	µg	NOUN
eurjchem-596	266	5	/	/	SYM
eurjchem-596	266	6	ml	ml	NOUN
eurjchem-596	266	7	)	)	PUNCT
eurjchem-596	266	8	ic50	ic50	PROPN
eurjchem-596	266	9	a	a	PRON
eurjchem-596	266	10	(	(	PUNCT
eurjchem-596	266	11	µm	µm	NOUN
eurjchem-596	266	12	)	)	PUNCT
eurjchem-596	266	13	concentration	concentration	NOUN
eurjchem-596	266	14	(	(	PUNCT
eurjchem-596	266	15	µg	µg	NOUN
eurjchem-596	266	16	/	/	SYM
eurjchem-596	266	17	ml	ml	NOUN
eurjchem-596	266	18	)	)	PUNCT
eurjchem-596	266	19	100	100	NUM
eurjchem-596	266	20	50	50	NUM
eurjchem-596	266	21	25	25	NUM
eurjchem-596	266	22	10	10	NUM
eurjchem-596	266	23	4a	4a	NOUN
eurjchem-596	266	24	100	100	NUM
eurjchem-596	266	25	50	50	NUM
eurjchem-596	266	26	25	25	NUM
eurjchem-596	266	27	10	10	NUM
eurjchem-596	266	28	25	25	NUM
eurjchem-596	266	29	62.34	62.34	NUM
eurjchem-596	266	30	4b	4b	NOUN
eurjchem-596	266	31	100	100	NUM
eurjchem-596	266	32	50	50	NUM
eurjchem-596	266	33	25	25	NUM
eurjchem-596	266	34	10	10	NUM
eurjchem-596	266	35	50	50	NUM
eurjchem-596	266	36	119.9	119.9	NUM
eurjchem-596	266	37	4c	4c	NOUN
eurjchem-596	266	38	100	100	NUM
eurjchem-596	266	39	60	60	NUM
eurjchem-596	266	40	40	40	NUM
eurjchem-596	266	41	10	10	NUM
eurjchem-596	266	42	46	46	NUM
eurjchem-596	266	43	106.48	106.48	NUM
eurjchem-596	266	44	4d	4d	NOUN
eurjchem-596	266	45	60	60	NUM
eurjchem-596	266	46	75	75	NUM
eurjchem-596	266	47	50	50	NUM
eurjchem-596	266	48	20	20	NUM
eurjchem-596	266	49	25	25	NUM
eurjchem-596	266	50	57.87	57.87	NUM
eurjchem-596	266	51	4e	4e	NOUN
eurjchem-596	266	52	100	100	NUM
eurjchem-596	266	53	90	90	NUM
eurjchem-596	266	54	70	70	NUM
eurjchem-596	266	55	10	10	NUM
eurjchem-596	266	56	45	45	NUM
eurjchem-596	266	57	104.4	104.4	NUM
eurjchem-596	266	58	4f	4f	NUM
eurjchem-596	266	59	100	100	NUM
eurjchem-596	266	60	50	50	NUM
eurjchem-596	266	61	25	25	NUM
eurjchem-596	266	62	10	10	NUM
eurjchem-596	266	63	50	50	NUM
eurjchem-596	266	64	108.45	108.45	NUM
eurjchem-596	266	65	4	4	NUM
eurjchem-596	266	66	g	g	NOUN
eurjchem-596	266	67	95	95	NUM
eurjchem-596	266	68	55	55	NUM
eurjchem-596	266	69	40	40	NUM
eurjchem-596	266	70	5	5	NUM
eurjchem-596	266	71	48	48	NUM
eurjchem-596	266	72	83.76	83.76	NUM
eurjchem-596	266	73	4h	4h	NUM
eurjchem-596	266	74	90	90	NUM
eurjchem-596	266	75	70	70	NUM
eurjchem-596	266	76	30	30	NUM
eurjchem-596	266	77	10	10	NUM
eurjchem-596	266	78	49	49	NUM
eurjchem-596	266	79	116.38	116.38	NUM
eurjchem-596	266	80	4i	4i	NOUN
eurjchem-596	266	81	95	95	NUM
eurjchem-596	266	82	60	60	NUM
eurjchem-596	266	83	30	30	NUM
eurjchem-596	266	84	10	10	NUM
eurjchem-596	266	85	49	49	NUM
eurjchem-596	266	86	105.15	105.15	NUM
eurjchem-596	266	87	4j	4j	NOUN
eurjchem-596	266	88	95	95	NUM
eurjchem-596	266	89	65	65	NUM
eurjchem-596	266	90	20	20	NUM
eurjchem-596	266	91	5	5	NUM
eurjchem-596	266	92	47	47	NUM
eurjchem-596	266	93	119.59	119.59	NUM
eurjchem-596	266	94	6a	6a	NOUN
eurjchem-596	266	95	95	95	NUM
eurjchem-596	266	96	80	80	NUM
eurjchem-596	266	97	60	60	NUM
eurjchem-596	266	98	10	10	NUM
eurjchem-596	266	99	23	23	NUM
eurjchem-596	266	100	58.52	58.52	NUM
eurjchem-596	266	101	6b	6b	NUM
eurjchem-596	266	102	50	50	NUM
eurjchem-596	266	103	10	10	NUM
eurjchem-596	266	104	0	0	NUM
eurjchem-596	266	105	0	0	NUM
eurjchem-596	266	106	100	100	NUM
eurjchem-596	266	107	244.5	244.5	NUM
eurjchem-596	266	108	6c	6c	NOUN
eurjchem-596	266	109	100	100	NUM
eurjchem-596	266	110	100	100	NUM
eurjchem-596	266	111	60	60	NUM
eurjchem-596	266	112	30	30	NUM
eurjchem-596	266	113	15	15	NUM
eurjchem-596	266	114	36.67	36.67	NUM
eurjchem-596	266	115	6d	6d	NUM
eurjchem-596	266	116	100	100	NUM
eurjchem-596	266	117	60	60	NUM
eurjchem-596	266	118	40	40	NUM
eurjchem-596	266	119	5	5	NUM
eurjchem-596	266	120	46	46	NUM
eurjchem-596	266	121	108.49	108.49	NUM
eurjchem-596	266	122	6e	6e	NUM
eurjchem-596	266	123	100	100	NUM
eurjchem-596	266	124	90	90	NUM
eurjchem-596	266	125	50	50	NUM
eurjchem-596	266	126	20	20	NUM
eurjchem-596	266	127	25	25	NUM
eurjchem-596	266	128	58.96	58.96	NUM
eurjchem-596	266	129	6f	6f	NUM
eurjchem-596	266	130	100	100	NUM
eurjchem-596	266	131	70	70	NUM
eurjchem-596	266	132	40	40	NUM
eurjchem-596	266	133	10	10	NUM
eurjchem-596	266	134	43	43	NUM
eurjchem-596	266	135	91.68	91.68	NUM
eurjchem-596	266	136	6	6	NUM
eurjchem-596	266	137	g	g	PROPN
eurjchem-596	266	138	100	100	NUM
eurjchem-596	266	139	50	50	NUM
eurjchem-596	266	140	25	25	NUM
eurjchem-596	266	141	10	10	NUM
eurjchem-596	266	142	50	50	NUM
eurjchem-596	266	143	121.06	121.06	NUM
eurjchem-596	266	144	6h	6h	NOUN
eurjchem-596	266	145	100	100	NUM
eurjchem-596	266	146	60	60	NUM
eurjchem-596	266	147	30	30	NUM
eurjchem-596	266	148	5	5	NUM
eurjchem-596	266	149	48	48	NUM
eurjchem-596	266	150	107.14	107.14	NUM
eurjchem-596	266	151	7	7	NUM
eurjchem-596	266	152	30	30	NUM
eurjchem-596	266	153	0	0	NUM
eurjchem-596	266	154	0	0	NUM
eurjchem-596	266	155	0	0	NUM
eurjchem-596	266	156	>	>	PUNCT
eurjchem-596	266	157	100b	100b	NUM
eurjchem-596	266	158	‐	‐	VERB
eurjchem-596	266	159	8	8	NUM
eurjchem-596	266	160	20	20	NUM
eurjchem-596	266	161	0	0	NUM
eurjchem-596	266	162	0	0	NUM
eurjchem-596	266	163	0	0	NUM
eurjchem-596	266	164	>	>	PUNCT
eurjchem-596	266	165	100b	100b	NUM
eurjchem-596	266	166	‐	‐	NOUN
eurjchem-596	266	167	9	9	NUM
eurjchem-596	266	168	100	100	NUM
eurjchem-596	266	169	80	80	NUM
eurjchem-596	266	170	25	25	NUM
eurjchem-596	266	171	10	10	NUM
eurjchem-596	266	172	44	44	NUM
eurjchem-596	266	173	123.24	123.24	NUM
eurjchem-596	266	174	10	10	NUM
eurjchem-596	266	175	100	100	NUM
eurjchem-596	266	176	90	90	NUM
eurjchem-596	266	177	60	60	NUM
eurjchem-596	266	178	30	30	NUM
eurjchem-596	266	179	21	21	NUM
eurjchem-596	266	180	58.98	58.98	NUM
eurjchem-596	266	181	doxorubicin	doxorubicin	PROPN
eurjchem-596	266	182	100	100	NUM
eurjchem-596	266	183	68	68	NUM
eurjchem-596	266	184	30	30	NUM
eurjchem-596	266	185	24	24	NUM
eurjchem-596	266	186	37	37	NUM
eurjchem-596	266	187	68.13	68.13	NUM
eurjchem-596	266	188	a	a	DET
eurjchem-596	266	189	ic50	ic50	PROPN
eurjchem-596	266	190	value	value	NOUN
eurjchem-596	266	191	:	:	PUNCT
eurjchem-596	266	192	corresponds	correspond	VERB
eurjchem-596	266	193	to	to	ADP
eurjchem-596	266	194	the	the	DET
eurjchem-596	266	195	compound	compound	NOUN
eurjchem-596	266	196	concentration	concentration	NOUN
eurjchem-596	266	197	causing	cause	VERB
eurjchem-596	266	198	50	50	NUM
eurjchem-596	266	199	%	%	NOUN
eurjchem-596	266	200	mortality	mortality	NOUN
eurjchem-596	266	201	in	in	ADP
eurjchem-596	266	202	net	net	ADJ
eurjchem-596	266	203	cells	cell	NOUN
eurjchem-596	266	204	.	.	PUNCT
eurjchem-596	267	1	b	b	NOUN
eurjchem-596	267	2	compounds	compound	NOUN
eurjchem-596	267	3	with	with	ADP
eurjchem-596	267	4	ic50	ic50	PROPN
eurjchem-596	267	5	>	>	PROPN
eurjchem-596	267	6	100	100	NUM
eurjchem-596	267	7	lg	lg	NOUN
eurjchem-596	267	8	/	/	SYM
eurjchem-596	267	9	ml	ml	NOUN
eurjchem-596	267	10	are	be	AUX
eurjchem-596	267	11	considered	consider	VERB
eurjchem-596	267	12	to	to	PART
eurjchem-596	267	13	be	be	AUX
eurjchem-596	267	14	inactive	inactive	ADJ
eurjchem-596	267	15	.	.	PUNCT
eurjchem-596	268	1	2.3.5	2.3.5	NUM
eurjchem-596	268	2	.	.	PUNCT
eurjchem-596	268	3	in‐vitro	in‐vitro	NOUN
eurjchem-596	268	4	anticancer	anticancer	NOUN
eurjchem-596	268	5	activity	activity	NOUN
eurjchem-596	268	6	using	use	VERB
eurjchem-596	268	7	liver	liver	NOUN
eurjchem-596	268	8	human	human	ADJ
eurjchem-596	268	9	tumor	tumor	NOUN
eurjchem-596	268	10	cell	cell	NOUN
eurjchem-596	268	11	lines	line	NOUN
eurjchem-596	268	12	(	(	PUNCT
eurjchem-596	268	13	hepg2	hepg2	VERB
eurjchem-596	268	14	)	)	PUNCT
eurjchem-596	268	15	the	the	DET
eurjchem-596	268	16	human	human	ADJ
eurjchem-596	268	17	tumor	tumor	NOUN
eurjchem-596	268	18	cell	cell	NOUN
eurjchem-596	268	19	line	line	NOUN
eurjchem-596	268	20	(	(	PUNCT
eurjchem-596	268	21	hepg2	hepg2	VERB
eurjchem-596	268	22	)	)	PUNCT
eurjchem-596	268	23	was	be	AUX
eurjchem-596	268	24	available	available	ADJ
eurjchem-596	268	25	at	at	ADP
eurjchem-596	268	26	the	the	DET
eurjchem-596	268	27	national	national	PROPN
eurjchem-596	268	28	cancer	cancer	PROPN
eurjchem-596	268	29	institute	institute	PROPN
eurjchem-596	268	30	,	,	PUNCT
eurjchem-596	268	31	cairo	cairo	PROPN
eurjchem-596	268	32	,	,	PUNCT
eurjchem-596	268	33	egypt	egypt	PROPN
eurjchem-596	268	34	.	.	PUNCT
eurjchem-596	269	1	irradiation	irradiation	NOUN
eurjchem-596	269	2	was	be	AUX
eurjchem-596	269	3	performed	perform	VERB
eurjchem-596	269	4	in	in	ADP
eurjchem-596	269	5	the	the	DET
eurjchem-596	269	6	national	national	PROPN
eurjchem-596	269	7	cancer	cancer	PROPN
eurjchem-596	269	8	institute	institute	PROPN
eurjchem-596	269	9	,	,	PUNCT
eurjchem-596	269	10	cairo	cairo	PROPN
eurjchem-596	269	11	,	,	PUNCT
eurjchem-596	269	12	egypt	egypt	PROPN
eurjchem-596	269	13	using	use	VERB
eurjchem-596	269	14	gamma	gamma	PROPN
eurjchem-596	269	15	cell‐40	cell‐40	PROPN
eurjchem-596	269	16	(	(	PUNCT
eurjchem-596	269	17	60co	60co	NOUN
eurjchem-596	269	18	)	)	PUNCT
eurjchem-596	269	19	source	source	NOUN
eurjchem-596	269	20	.	.	PUNCT
eurjchem-596	270	1	the	the	DET
eurjchem-596	270	2	anticancer	anticancer	NOUN
eurjchem-596	270	3	activity	activity	NOUN
eurjchem-596	270	4	of	of	ADP
eurjchem-596	270	5	the	the	DET
eurjchem-596	270	6	newly	newly	ADV
eurjchem-596	270	7	synthesized	synthesize	VERB
eurjchem-596	270	8	compounds	compound	NOUN
eurjchem-596	270	9	was	be	AUX
eurjchem-596	270	10	mesured	mesure	VERB
eurjchem-596	270	11	using	use	VERB
eurjchem-596	270	12	the	the	DET
eurjchem-596	270	13	sulfo‐	sulfo‐	PROPN
eurjchem-596	270	14	rhodamine‐b	rhodamine‐b	ADJ
eurjchem-596	270	15	stain	stain	NOUN
eurjchem-596	270	16	(	(	PUNCT
eurjchem-596	270	17	srb	srb	PROPN
eurjchem-596	270	18	)	)	PUNCT
eurjchem-596	270	19	assay	assay	VERB
eurjchem-596	270	20	by	by	ADP
eurjchem-596	270	21	the	the	DET
eurjchem-596	270	22	method	method	NOUN
eurjchem-596	270	23	of	of	ADP
eurjchem-596	270	24	skehan	skehan	PROPN
eurjchem-596	270	25	et	et	PROPN
eurjchem-596	270	26	al	al	PROPN
eurjchem-596	270	27	.	.	PUNCT
eurjchem-596	271	1	[	[	X
eurjchem-596	271	2	18	18	NUM
eurjchem-596	271	3	]	]	PUNCT
eurjchem-596	271	4	.	.	PUNCT
eurjchem-596	272	1	cells	cell	NOUN
eurjchem-596	272	2	were	be	AUX
eurjchem-596	272	3	plated	plate	VERB
eurjchem-596	272	4	in	in	ADP
eurjchem-596	272	5	96‐multiwell	96‐multiwell	NUM
eurjchem-596	272	6	plate	plate	NOUN
eurjchem-596	272	7	(	(	PUNCT
eurjchem-596	272	8	104	104	NUM
eurjchem-596	272	9	cells	cell	NOUN
eurjchem-596	272	10	/	/	SYM
eurjchem-596	272	11	well	well	INTJ
eurjchem-596	272	12	)	)	PUNCT
eurjchem-596	272	13	for	for	ADP
eurjchem-596	272	14	24	24	NUM
eurjchem-596	272	15	h	h	NOUN
eurjchem-596	272	16	before	before	ADP
eurjchem-596	272	17	treatment	treatment	NOUN
eurjchem-596	272	18	with	with	ADP
eurjchem-596	272	19	the	the	DET
eurjchem-596	272	20	compounds	compound	NOUN
eurjchem-596	272	21	to	to	PART
eurjchem-596	272	22	allow	allow	VERB
eurjchem-596	272	23	attachment	attachment	NOUN
eurjchem-596	272	24	of	of	ADP
eurjchem-596	272	25	cell	cell	NOUN
eurjchem-596	272	26	to	to	ADP
eurjchem-596	272	27	the	the	DET
eurjchem-596	272	28	wall	wall	NOUN
eurjchem-596	272	29	of	of	ADP
eurjchem-596	272	30	the	the	DET
eurjchem-596	272	31	plate	plate	NOUN
eurjchem-596	272	32	.	.	PUNCT
eurjchem-596	273	1	tested	test	VERB
eurjchem-596	273	2	compounds	compound	NOUN
eurjchem-596	273	3	were	be	AUX
eurjchem-596	273	4	dissolved	dissolve	VERB
eurjchem-596	273	5	in	in	ADP
eurjchem-596	273	6	dmso	dmso	NOUN
eurjchem-596	273	7	and	and	CCONJ
eurjchem-596	273	8	diluted	dilute	VERB
eurjchem-596	273	9	with	with	ADP
eurjchem-596	273	10	saline	saline	NOUN
eurjchem-596	273	11	to	to	ADP
eurjchem-596	273	12	the	the	DET
eurjchem-596	273	13	appropriate	appropriate	ADJ
eurjchem-596	273	14	volume	volume	NOUN
eurjchem-596	273	15	.	.	PUNCT
eurjchem-596	274	1	different	different	ADJ
eurjchem-596	274	2	concentrations	concentration	NOUN
eurjchem-596	274	3	of	of	ADP
eurjchem-596	274	4	the	the	DET
eurjchem-596	274	5	compounds	compound	NOUN
eurjchem-596	274	6	under	under	ADP
eurjchem-596	274	7	test	test	NOUN
eurjchem-596	274	8	(	(	PUNCT
eurjchem-596	274	9	5.0	5.0	NUM
eurjchem-596	274	10	,	,	PUNCT
eurjchem-596	274	11	12.5	12.5	NUM
eurjchem-596	274	12	,	,	PUNCT
eurjchem-596	274	13	25.0	25.0	NUM
eurjchem-596	274	14	and	and	CCONJ
eurjchem-596	274	15	50.0	50.0	NUM
eurjchem-596	274	16	μm	μm	NUM
eurjchem-596	274	17	)	)	PUNCT
eurjchem-596	274	18	were	be	AUX
eurjchem-596	274	19	added	add	VERB
eurjchem-596	274	20	to	to	ADP
eurjchem-596	274	21	the	the	DET
eurjchem-596	274	22	cell	cell	NOUN
eurjchem-596	274	23	monolayer	monolayer	NOUN
eurjchem-596	274	24	.	.	PUNCT
eurjchem-596	275	1	triplicate	triplicate	VERB
eurjchem-596	275	2	wells	well	NOUN
eurjchem-596	275	3	were	be	AUX
eurjchem-596	275	4	prepared	prepare	VERB
eurjchem-596	275	5	for	for	ADP
eurjchem-596	275	6	each	each	DET
eurjchem-596	275	7	individual	individual	ADJ
eurjchem-596	275	8	dose	dose	PROPN
eurjchem-596	275	9	.	.	PUNCT
eurjchem-596	276	1	monolayer	monolayer	NOUN
eurjchem-596	276	2	cells	cell	NOUN
eurjchem-596	276	3	were	be	AUX
eurjchem-596	276	4	incubated	incubate	VERB
eurjchem-596	276	5	with	with	ADP
eurjchem-596	276	6	the	the	DET
eurjchem-596	276	7	compounds	compound	NOUN
eurjchem-596	276	8	for	for	ADP
eurjchem-596	276	9	48	48	NUM
eurjchem-596	276	10	h	h	NOUN
eurjchem-596	276	11	at	at	ADP
eurjchem-596	276	12	37	37	NUM
eurjchem-596	276	13	oc	oc	NOUN
eurjchem-596	276	14	and	and	CCONJ
eurjchem-596	276	15	in	in	ADP
eurjchem-596	276	16	atmosphere	atmosphere	NOUN
eurjchem-596	276	17	of	of	ADP
eurjchem-596	276	18	5	5	NUM
eurjchem-596	276	19	%	%	NOUN
eurjchem-596	276	20	co2	co2	NOUN
eurjchem-596	276	21	.	.	PUNCT
eurjchem-596	277	1	after	after	ADP
eurjchem-596	277	2	48	48	NUM
eurjchem-596	277	3	h	h	NOUN
eurjchem-596	277	4	,	,	PUNCT
eurjchem-596	277	5	cells	cell	NOUN
eurjchem-596	277	6	were	be	AUX
eurjchem-596	277	7	fixed	fix	VERB
eurjchem-596	277	8	,	,	PUNCT
eurjchem-596	277	9	washed	wash	VERB
eurjchem-596	277	10	and	and	CCONJ
eurjchem-596	277	11	stained	stain	VERB
eurjchem-596	277	12	for	for	ADP
eurjchem-596	277	13	30	30	NUM
eurjchem-596	277	14	min	min	NOUN
eurjchem-596	277	15	.	.	PROPN
eurjchem-596	277	16	with	with	ADP
eurjchem-596	277	17	0.4	0.4	NUM
eurjchem-596	277	18	%	%	NOUN
eurjchem-596	277	19	(	(	PUNCT
eurjchem-596	277	20	wt	wt	NOUN
eurjchem-596	277	21	/	/	SYM
eurjchem-596	277	22	vol	vol	NOUN
eurjchem-596	277	23	)	)	PUNCT
eurjchem-596	277	24	with	with	SCONJ
eurjchem-596	277	25	srb	srb	NOUN
eurjchem-596	277	26	dissolved	dissolve	VERB
eurjchem-596	277	27	in	in	ADP
eurjchem-596	277	28	1	1	NUM
eurjchem-596	277	29	%	%	NOUN
eurjchem-596	277	30	acetic	acetic	ADJ
eurjchem-596	277	31	acid	acid	NOUN
eurjchem-596	277	32	.	.	PUNCT
eurjchem-596	278	1	unbounded	unbounded	ADJ
eurjchem-596	278	2	dye	dye	NOUN
eurjchem-596	278	3	was	be	AUX
eurjchem-596	278	4	removed	remove	VERB
eurjchem-596	278	5	by	by	ADP
eurjchem-596	278	6	four	four	NUM
eurjchem-596	278	7	washes	wash	NOUN
eurjchem-596	278	8	with	with	ADP
eurjchem-596	278	9	1	1	NUM
eurjchem-596	278	10	%	%	NOUN
eurjchem-596	278	11	acetic	acetic	ADJ
eurjchem-596	278	12	acid	acid	NOUN
eurjchem-596	278	13	,	,	PUNCT
eurjchem-596	278	14	and	and	CCONJ
eurjchem-596	278	15	attached	attach	VERB
eurjchem-596	278	16	stain	stain	NOUN
eurjchem-596	278	17	was	be	AUX
eurjchem-596	278	18	recovered	recover	VERB
eurjchem-596	278	19	with	with	ADP
eurjchem-596	278	20	tris‐edta	tris‐edta	NOUN
eurjchem-596	278	21	buffer	buffer	NOUN
eurjchem-596	278	22	.	.	PUNCT
eurjchem-596	279	1	color	color	NOUN
eurjchem-596	279	2	intensity	intensity	NOUN
eurjchem-596	279	3	was	be	AUX
eurjchem-596	279	4	measured	measure	VERB
eurjchem-596	279	5	in	in	ADP
eurjchem-596	279	6	an	an	DET
eurjchem-596	279	7	elisa	elisa	NOUN
eurjchem-596	279	8	reader	reader	NOUN
eurjchem-596	279	9	.	.	PUNCT
eurjchem-596	280	1	the	the	DET
eurjchem-596	280	2	relation	relation	NOUN
eurjchem-596	280	3	between	between	ADP
eurjchem-596	280	4	surviving	survive	VERB
eurjchem-596	280	5	fraction	fraction	NOUN
eurjchem-596	280	6	and	and	CCONJ
eurjchem-596	280	7	drug	drug	NOUN
eurjchem-596	280	8	concentration	concentration	NOUN
eurjchem-596	280	9	was	be	AUX
eurjchem-596	280	10	plotted	plot	VERB
eurjchem-596	280	11	to	to	PART
eurjchem-596	280	12	get	get	VERB
eurjchem-596	280	13	the	the	DET
eurjchem-596	280	14	survival	survival	NOUN
eurjchem-596	280	15	curve	curve	NOUN
eurjchem-596	280	16	of	of	ADP
eurjchem-596	280	17	each	each	DET
eurjchem-596	280	18	tumor	tumor	NOUN
eurjchem-596	280	19	cell	cell	NOUN
eurjchem-596	280	20	line	line	NOUN
eurjchem-596	280	21	after	after	ADP
eurjchem-596	280	22	the	the	DET
eurjchem-596	280	23	specified	specified	ADJ
eurjchem-596	280	24	time	time	NOUN
eurjchem-596	280	25	.	.	PUNCT
eurjchem-596	281	1	the	the	DET
eurjchem-596	281	2	concentration	concentration	NOUN
eurjchem-596	281	3	required	require	VERB
eurjchem-596	281	4	for	for	ADP
eurjchem-596	281	5	50	50	NUM
eurjchem-596	281	6	%	%	NOUN
eurjchem-596	281	7	inhibition	inhibition	NOUN
eurjchem-596	281	8	of	of	ADP
eurjchem-596	281	9	cell	cell	NOUN
eurjchem-596	281	10	viability	viability	NOUN
eurjchem-596	281	11	(	(	PUNCT
eurjchem-596	281	12	ic50	ic50	PROPN
eurjchem-596	281	13	)	)	PUNCT
eurjchem-596	281	14	was	be	AUX
eurjchem-596	281	15	calculated	calculate	VERB
eurjchem-596	281	16	and	and	CCONJ
eurjchem-596	281	17	compared	compare	VERB
eurjchem-596	281	18	with	with	ADP
eurjchem-596	281	19	the	the	DET
eurjchem-596	281	20	reference	reference	NOUN
eurjchem-596	281	21	drug	drug	NOUN
eurjchem-596	281	22	doxorubicin	doxorubicin	PROPN
eurjchem-596	281	23	and	and	CCONJ
eurjchem-596	281	24	the	the	DET
eurjchem-596	281	25	results	result	NOUN
eurjchem-596	281	26	are	be	AUX
eurjchem-596	281	27	given	give	VERB
eurjchem-596	281	28	in	in	ADP
eurjchem-596	281	29	table	table	NOUN
eurjchem-596	281	30	2	2	NUM
eurjchem-596	281	31	.	.	PUNCT
eurjchem-596	282	1	al‐said	al‐said	PROPN
eurjchem-596	282	2	et	et	PROPN
eurjchem-596	282	3	al	al	PROPN
eurjchem-596	282	4	.	.	PUNCT
eurjchem-596	282	5	/	/	SYM
eurjchem-596	282	6	european	european	PROPN
eurjchem-596	282	7	journal	journal	PROPN
eurjchem-596	282	8	of	of	ADP
eurjchem-596	282	9	chemistry	chemistry	NOUN
eurjchem-596	282	10	3	3	NUM
eurjchem-596	282	11	(	(	PUNCT
eurjchem-596	282	12	2	2	NUM
eurjchem-596	282	13	)	)	PUNCT
eurjchem-596	282	14	(	(	PUNCT
eurjchem-596	282	15	2012	2012	NUM
eurjchem-596	282	16	)	)	PUNCT
eurjchem-596	282	17	228‐234	228‐234	PROPN
eurjchem-596	282	18	233	233	NUM
eurjchem-596	282	19	table	table	NOUN
eurjchem-596	282	20	2	2	NUM
eurjchem-596	282	21	.	.	PUNCT
eurjchem-596	282	22	in‐vitro	in‐vitro	VERB
eurjchem-596	282	23	anticancer	anticancer	NOUN
eurjchem-596	282	24	evaluation	evaluation	NOUN
eurjchem-596	282	25	of	of	ADP
eurjchem-596	282	26	compounds	compound	NOUN
eurjchem-596	282	27	4a	4a	NUM
eurjchem-596	282	28	,	,	PUNCT
eurjchem-596	282	29	4d	4d	NUM
eurjchem-596	282	30	,	,	PUNCT
eurjchem-596	282	31	6a	6a	NOUN
eurjchem-596	282	32	,	,	PUNCT
eurjchem-596	282	33	6c	6c	NOUN
eurjchem-596	282	34	,	,	PUNCT
eurjchem-596	282	35	6e	6e	NUM
eurjchem-596	282	36	and	and	CCONJ
eurjchem-596	282	37	10	10	NUM
eurjchem-596	282	38	against	against	ADP
eurjchem-596	282	39	human	human	ADJ
eurjchem-596	282	40	liver	liver	NOUN
eurjchem-596	282	41	cell	cell	NOUN
eurjchem-596	282	42	line	line	NOUN
eurjchem-596	282	43	(	(	PUNCT
eurjchem-596	282	44	hepg2	hepg2	NOUN
eurjchem-596	282	45	)	)	PUNCT
eurjchem-596	282	46	.	.	PUNCT
eurjchem-596	283	1	compound	compound	VERB
eurjchem-596	283	2	no	no	DET
eurjchem-596	283	3	compound	compound	NOUN
eurjchem-596	283	4	concentration	concentration	NOUN
eurjchem-596	283	5	(	(	PUNCT
eurjchem-596	283	6	µm	µm	NOUN
eurjchem-596	283	7	)	)	PUNCT
eurjchem-596	283	8	ic50	ic50	PROPN
eurjchem-596	283	9	(	(	PUNCT
eurjchem-596	283	10	µm	µm	NOUN
eurjchem-596	283	11	)	)	PUNCT
eurjchem-596	283	12	5.0	5.0	NUM
eurjchem-596	283	13	12.5	12.5	NUM
eurjchem-596	283	14	25.0	25.0	NUM
eurjchem-596	283	15	50.0	50.0	NUM
eurjchem-596	283	16	surviving	survive	VERB
eurjchem-596	283	17	fraction	fraction	NOUN
eurjchem-596	283	18	(	(	PUNCT
eurjchem-596	283	19	mean	mean	NOUN
eurjchem-596	283	20	±	±	NUM
eurjchem-596	283	21	se)a	se)a	NOUN
eurjchem-596	283	22	doxorubicin	doxorubicin	VERB
eurjchem-596	283	23	0.921	0.921	NUM
eurjchem-596	283	24	±	±	NUM
eurjchem-596	283	25	0.020	0.020	NUM
eurjchem-596	283	26	0.846	0.846	NUM
eurjchem-596	283	27	±	±	NUM
eurjchem-596	283	28	0.020	0.020	NUM
eurjchem-596	283	29	0.761	0.761	NUM
eurjchem-596	283	30	±	±	NUM
eurjchem-596	283	31	0.010	0.010	NUM
eurjchem-596	283	32	0.494	0.494	NUM
eurjchem-596	283	33	±	±	NUM
eurjchem-596	283	34	0.030	0.030	NUM
eurjchem-596	283	35	38.46	38.46	NUM
eurjchem-596	283	36	4a	4a	NOUN
eurjchem-596	283	37	0.845	0.845	NUM
eurjchem-596	283	38	±	±	NUM
eurjchem-596	283	39	0.002	0.002	NUM
eurjchem-596	283	40	0.724	0.724	NUM
eurjchem-596	283	41	±	±	NUM
eurjchem-596	283	42	0.009	0.009	NUM
eurjchem-596	283	43	0.576	0.576	NUM
eurjchem-596	283	44	±	±	NUM
eurjchem-596	283	45	0.028	0.028	NUM
eurjchem-596	283	46	0.376	0.376	NUM
eurjchem-596	283	47	±	±	NUM
eurjchem-596	283	48	0.047	0.047	NUM
eurjchem-596	283	49	31.2	31.2	NUM
eurjchem-596	283	50	4d	4d	NUM
eurjchem-596	283	51	0.623	0.623	NUM
eurjchem-596	283	52	±	±	NUM
eurjchem-596	283	53	0.018	0.018	NUM
eurjchem-596	283	54	0.523	0.523	NUM
eurjchem-596	283	55	±	±	NUM
eurjchem-596	283	56	0.031	0.031	NUM
eurjchem-596	283	57	0.367	0.367	NUM
eurjchem-596	283	58	±	±	NUM
eurjchem-596	283	59	0.022	0.022	NUM
eurjchem-596	283	60	0.271	0.271	NUM
eurjchem-596	283	61	±	±	NUM
eurjchem-596	283	62	0.012	0.012	NUM
eurjchem-596	283	63	11.7	11.7	NUM
eurjchem-596	283	64	6a	6a	NOUN
eurjchem-596	283	65	0.723	0.723	NUM
eurjchem-596	283	66	±	±	NUM
eurjchem-596	283	67	0.012	0.012	NUM
eurjchem-596	283	68	0.635	0.635	NUM
eurjchem-596	283	69	±	±	NUM
eurjchem-596	283	70	0.041	0.041	NUM
eurjchem-596	283	71	0.523	0.523	NUM
eurjchem-596	284	1	±0.047	±0.047	ADP
eurjchem-596	284	2	0.244	0.244	NUM
eurjchem-596	284	3	±	±	NUM
eurjchem-596	284	4	0.022	0.022	NUM
eurjchem-596	284	5	21.81	21.81	NUM
eurjchem-596	284	6	6c	6c	NOUN
eurjchem-596	284	7	0.922	0.922	NUM
eurjchem-596	284	8	±	±	NUM
eurjchem-596	284	9	0.064	0.064	NUM
eurjchem-596	284	10	0.744	0.744	NUM
eurjchem-596	284	11	±	±	NUM
eurjchem-596	284	12	0.014	0.014	NUM
eurjchem-596	284	13	0.630	0.630	NUM
eurjchem-596	284	14	±	±	NUM
eurjchem-596	284	15	0.016	0.016	NUM
eurjchem-596	284	16	0.436	0.436	NUM
eurjchem-596	284	17	±	±	NUM
eurjchem-596	284	18	0.012	0.012	NUM
eurjchem-596	284	19	38.9	38.9	NUM
eurjchem-596	284	20	6e	6e	NOUN
eurjchem-596	284	21	0.876	0.876	NUM
eurjchem-596	284	22	±	±	NUM
eurjchem-596	284	23	0.064	0.064	NUM
eurjchem-596	284	24	0.744	0.744	NUM
eurjchem-596	284	25	±	±	NUM
eurjchem-596	284	26	0.014	0.014	NUM
eurjchem-596	284	27	0.509	0.509	NUM
eurjchem-596	284	28	±	±	NUM
eurjchem-596	284	29	0.016	0.016	NUM
eurjchem-596	284	30	0.312	0.312	NUM
eurjchem-596	284	31	±	±	NUM
eurjchem-596	284	32	0.012	0.012	NUM
eurjchem-596	284	33	25.83	25.83	NUM
eurjchem-596	284	34	10	10	NUM
eurjchem-596	284	35	0.910	0.910	NUM
eurjchem-596	284	36	±	±	NUM
eurjchem-596	284	37	0.064	0.064	NUM
eurjchem-596	284	38	0.789	0.789	NUM
eurjchem-596	284	39	±	±	NUM
eurjchem-596	284	40	0.014	0.014	NUM
eurjchem-596	284	41	0.598	0.598	NUM
eurjchem-596	284	42	±	±	NUM
eurjchem-596	284	43	0.016	0.016	NUM
eurjchem-596	284	44	0.309	0.309	NUM
eurjchem-596	284	45	±	±	NUM
eurjchem-596	284	46	0.012	0.012	NUM
eurjchem-596	284	47	32.2	32.2	NUM
eurjchem-596	284	48	a	a	DET
eurjchem-596	284	49	each	each	DET
eurjchem-596	284	50	value	value	NOUN
eurjchem-596	284	51	is	be	AUX
eurjchem-596	284	52	the	the	DET
eurjchem-596	284	53	mean	mean	NOUN
eurjchem-596	284	54	of	of	ADP
eurjchem-596	284	55	three	three	NUM
eurjchem-596	284	56	experiments	experiment	NOUN
eurjchem-596	284	57	±	±	NOUN
eurjchem-596	284	58	standard	standard	ADJ
eurjchem-596	284	59	error	error	NOUN
eurjchem-596	284	60	.	.	PUNCT
eurjchem-596	284	61	table	table	NOUN
eurjchem-596	284	62	3	3	NUM
eurjchem-596	284	63	.	.	PUNCT
eurjchem-596	284	64	in‐vitro	in‐vitro	VERB
eurjchem-596	284	65	anticancer	anticancer	NOUN
eurjchem-596	284	66	evaluation	evaluation	NOUN
eurjchem-596	284	67	of	of	ADP
eurjchem-596	284	68	compounds	compound	NOUN
eurjchem-596	284	69	4a	4a	NUM
eurjchem-596	284	70	,	,	PUNCT
eurjchem-596	284	71	4d	4d	NUM
eurjchem-596	284	72	,	,	PUNCT
eurjchem-596	284	73	6a	6a	NOUN
eurjchem-596	284	74	,	,	PUNCT
eurjchem-596	284	75	6c	6c	NOUN
eurjchem-596	284	76	,	,	PUNCT
eurjchem-596	284	77	6e	6e	NUM
eurjchem-596	284	78	and	and	CCONJ
eurjchem-596	284	79	10	10	NUM
eurjchem-596	284	80	against	against	ADP
eurjchem-596	284	81	human	human	ADJ
eurjchem-596	284	82	liver	liver	NOUN
eurjchem-596	284	83	cell	cell	NOUN
eurjchem-596	284	84	line	line	NOUN
eurjchem-596	284	85	(	(	PUNCT
eurjchem-596	284	86	hepg2	hepg2	NOUN
eurjchem-596	284	87	)	)	PUNCT
eurjchem-596	284	88	after	after	ADP
eurjchem-596	284	89	subjection	subjection	NOUN
eurjchem-596	284	90	to	to	ADP
eurjchem-596	284	91	radiation	radiation	NOUN
eurjchem-596	284	92	.	.	PUNCT
eurjchem-596	285	1	compound	compound	VERB
eurjchem-596	285	2	no	no	DET
eurjchem-596	285	3	compound	compound	NOUN
eurjchem-596	285	4	concentration	concentration	NOUN
eurjchem-596	285	5	(	(	PUNCT
eurjchem-596	285	6	µm	µm	NOUN
eurjchem-596	285	7	)	)	PUNCT
eurjchem-596	286	1	+	+	NUM
eurjchem-596	286	2	irradiation	irradiation	NOUN
eurjchem-596	286	3	(	(	PUNCT
eurjchem-596	286	4	8	8	NUM
eurjchem-596	286	5	gy	gy	NOUN
eurjchem-596	286	6	)	)	PUNCT
eurjchem-596	286	7	surviving	survive	VERB
eurjchem-596	286	8	fraction	fraction	NOUN
eurjchem-596	286	9	(	(	PUNCT
eurjchem-596	286	10	mean	mean	NOUN
eurjchem-596	286	11	±	±	NUM
eurjchem-596	286	12	se	se	X
eurjchem-596	286	13	)	)	PUNCT
eurjchem-596	286	14	a	a	DET
eurjchem-596	286	15	ic50	ic50	PROPN
eurjchem-596	286	16	(	(	PUNCT
eurjchem-596	286	17	µm	µm	NOUN
eurjchem-596	286	18	)	)	PUNCT
eurjchem-596	286	19	5.0	5.0	NUM
eurjchem-596	286	20	12.5	12.5	NUM
eurjchem-596	286	21	25.0	25.0	NUM
eurjchem-596	286	22	50.0	50.0	NUM
eurjchem-596	286	23	4a	4a	NOUN
eurjchem-596	286	24	0.587	0.587	NUM
eurjchem-596	286	25	±	±	NOUN
eurjchem-596	286	26	0.01	0.01	NUM
eurjchem-596	286	27	0.376	0.376	NUM
eurjchem-596	286	28	±	±	NUM
eurjchem-596	286	29	0.02	0.02	NUM
eurjchem-596	286	30	0.329	0.329	NUM
eurjchem-596	286	31	±	±	NUM
eurjchem-596	286	32	0.05	0.05	NUM
eurjchem-596	286	33	0.198	0.198	NUM
eurjchem-596	286	34	±	±	NUM
eurjchem-596	286	35	0.06	0.06	NUM
eurjchem-596	286	36	5.03	5.03	NUM
eurjchem-596	286	37	4d	4d	NUM
eurjchem-596	286	38	0.487	0.487	NUM
eurjchem-596	286	39	±	±	NOUN
eurjchem-596	286	40	0.07	0.07	NUM
eurjchem-596	286	41	0.398	0.398	NUM
eurjchem-596	286	42	±	±	NUM
eurjchem-596	286	43	0.01	0.01	NUM
eurjchem-596	286	44	0.198	0.198	NUM
eurjchem-596	286	45	±	±	NUM
eurjchem-596	286	46	0.01	0.01	NUM
eurjchem-596	286	47	0.100	0.100	NUM
eurjchem-596	286	48	±	±	NUM
eurjchem-596	286	49	0.08	0.08	NUM
eurjchem-596	286	50	6.37	6.37	NUM
eurjchem-596	286	51	6a	6a	NOUN
eurjchem-596	286	52	0.355	0.355	NUM
eurjchem-596	286	53	±	±	NOUN
eurjchem-596	286	54	0.01	0.01	NUM
eurjchem-596	286	55	0.276	0.276	NUM
eurjchem-596	286	56	±	±	NUM
eurjchem-596	286	57	0.01	0.01	NUM
eurjchem-596	286	58	0.245	0.245	NUM
eurjchem-596	286	59	±	±	NUM
eurjchem-596	286	60	0.01	0.01	NUM
eurjchem-596	286	61	0.187	0.187	NUM
eurjchem-596	286	62	±	±	NUM
eurjchem-596	286	63	0.07	0.07	NUM
eurjchem-596	286	64	2.68	2.68	NUM
eurjchem-596	286	65	6c	6c	NOUN
eurjchem-596	286	66	0.535	0.535	NUM
eurjchem-596	286	67	±	±	NUM
eurjchem-596	286	68	0.04	0.04	NUM
eurjchem-596	286	69	0.498	0.498	NUM
eurjchem-596	286	70	±	±	NUM
eurjchem-596	286	71	0.01	0.01	NUM
eurjchem-596	286	72	0.287	0.287	NUM
eurjchem-596	286	73	±	±	NUM
eurjchem-596	286	74	0.01	0.01	NUM
eurjchem-596	286	75	0.198	0.198	NUM
eurjchem-596	286	76	±	±	NUM
eurjchem-596	286	77	0.06	0.06	NUM
eurjchem-596	286	78	8.38	8.38	NUM
eurjchem-596	286	79	6e	6e	NUM
eurjchem-596	286	80	0.589	0.589	NUM
eurjchem-596	286	81	±	±	NUM
eurjchem-596	286	82	0.04	0.04	NUM
eurjchem-596	286	83	0.234	0.234	NUM
eurjchem-596	286	84	±	±	NUM
eurjchem-596	286	85	0.01	0.01	NUM
eurjchem-596	286	86	0.218	0.218	NUM
eurjchem-596	286	87	±	±	NUM
eurjchem-596	286	88	0.01	0.01	NUM
eurjchem-596	286	89	0.156	0.156	NUM
eurjchem-596	286	90	±	±	NUM
eurjchem-596	286	91	0.06	0.06	NUM
eurjchem-596	286	92	6.04	6.04	NUM
eurjchem-596	286	93	10	10	NUM
eurjchem-596	286	94	0.398	0.398	NUM
eurjchem-596	286	95	±	±	NUM
eurjchem-596	286	96	0.04	0.04	NUM
eurjchem-596	286	97	0.212	0.212	NUM
eurjchem-596	286	98	±	±	NUM
eurjchem-596	286	99	0.01	0.01	NUM
eurjchem-596	286	100	0.200	0.200	NUM
eurjchem-596	286	101	±	±	NUM
eurjchem-596	286	102	0.01	0.01	NUM
eurjchem-596	286	103	0.189	0.189	NUM
eurjchem-596	286	104	±	±	NUM
eurjchem-596	286	105	0.06	0.06	NUM
eurjchem-596	286	106	3.35	3.35	NUM
eurjchem-596	286	107	a	a	DET
eurjchem-596	286	108	each	each	DET
eurjchem-596	286	109	value	value	NOUN
eurjchem-596	286	110	is	be	AUX
eurjchem-596	286	111	the	the	DET
eurjchem-596	286	112	mean	mean	NOUN
eurjchem-596	286	113	of	of	ADP
eurjchem-596	286	114	three	three	NUM
eurjchem-596	286	115	experiments	experiment	NOUN
eurjchem-596	286	116	±	±	NOUN
eurjchem-596	286	117	standard	standard	ADJ
eurjchem-596	286	118	error	error	NOUN
eurjchem-596	286	119	.	.	PUNCT
eurjchem-596	287	1	2.4	2.4	NUM
eurjchem-596	287	2	.	.	PUNCT
eurjchem-596	288	1	radiosensitizing	radiosensitize	VERB
eurjchem-596	288	2	evaluation	evaluation	NOUN
eurjchem-596	288	3	the	the	DET
eurjchem-596	288	4	most	most	ADV
eurjchem-596	288	5	potent	potent	ADJ
eurjchem-596	288	6	compounds	compound	NOUN
eurjchem-596	288	7	resulted	result	VERB
eurjchem-596	288	8	from	from	ADP
eurjchem-596	288	9	the	the	DET
eurjchem-596	288	10	in	in	ADV
eurjchem-596	288	11	vitro	vitro	X
eurjchem-596	288	12	anticancer	anticancer	NOUN
eurjchem-596	288	13	screening	screening	NOUN
eurjchem-596	288	14	;	;	PUNCT
eurjchem-596	288	15	compounds	compound	NOUN
eurjchem-596	288	16	4a	4a	NOUN
eurjchem-596	288	17	,	,	PUNCT
eurjchem-596	288	18	4d	4d	NUM
eurjchem-596	288	19	,	,	PUNCT
eurjchem-596	288	20	6a	6a	NOUN
eurjchem-596	288	21	,	,	PUNCT
eurjchem-596	288	22	6c	6c	NOUN
eurjchem-596	288	23	,	,	PUNCT
eurjchem-596	288	24	6e	6e	NUM
eurjchem-596	288	25	and	and	CCONJ
eurjchem-596	288	26	10	10	NUM
eurjchem-596	288	27	,	,	PUNCT
eurjchem-596	288	28	were	be	AUX
eurjchem-596	288	29	selected	select	VERB
eurjchem-596	288	30	to	to	PART
eurjchem-596	288	31	be	be	AUX
eurjchem-596	288	32	evaluated	evaluate	VERB
eurjchem-596	288	33	again	again	ADV
eurjchem-596	288	34	for	for	ADP
eurjchem-596	288	35	their	their	PRON
eurjchem-596	288	36	in	in	ADP
eurjchem-596	288	37	vitro	vitro	X
eurjchem-596	288	38	anticancer	anticancer	NOUN
eurjchem-596	288	39	activity	activity	NOUN
eurjchem-596	288	40	alone	alone	ADJ
eurjchem-596	288	41	and	and	CCONJ
eurjchem-596	288	42	in	in	ADP
eurjchem-596	288	43	combination	combination	NOUN
eurjchem-596	288	44	with	with	ADP
eurjchem-596	288	45	γ‐radiation	γ‐radiation	NOUN
eurjchem-596	288	46	.	.	PUNCT
eurjchem-596	289	1	this	this	DET
eurjchem-596	289	2	study	study	NOUN
eurjchem-596	289	3	was	be	AUX
eurjchem-596	289	4	conducted	conduct	VERB
eurjchem-596	289	5	to	to	PART
eurjchem-596	289	6	evaluate	evaluate	VERB
eurjchem-596	289	7	the	the	DET
eurjchem-596	289	8	ability	ability	NOUN
eurjchem-596	289	9	of	of	ADP
eurjchem-596	289	10	these	these	DET
eurjchem-596	289	11	compounds	compound	NOUN
eurjchem-596	289	12	to	to	PART
eurjchem-596	289	13	enhance	enhance	VERB
eurjchem-596	289	14	the	the	DET
eurjchem-596	289	15	cell	cell	NOUN
eurjchem-596	289	16	killing	killing	NOUN
eurjchem-596	289	17	effect	effect	NOUN
eurjchem-596	289	18	of	of	ADP
eurjchem-596	289	19	γ‐radiation	γ‐radiation	PROPN
eurjchem-596	289	20	.	.	PUNCT
eurjchem-596	290	1	cells	cell	NOUN
eurjchem-596	290	2	were	be	AUX
eurjchem-596	290	3	subjected	subject	VERB
eurjchem-596	290	4	to	to	ADP
eurjchem-596	290	5	a	a	DET
eurjchem-596	290	6	single	single	ADJ
eurjchem-596	290	7	dose	dose	NOUN
eurjchem-596	290	8	of	of	ADP
eurjchem-596	290	9	γ‐radiation	γ‐radiation	PUNCT
eurjchem-596	290	10	at	at	ADP
eurjchem-596	290	11	a	a	DET
eurjchem-596	290	12	dose	dose	ADJ
eurjchem-596	290	13	level	level	NOUN
eurjchem-596	290	14	of	of	ADP
eurjchem-596	290	15	8	8	NUM
eurjchem-596	290	16	gy	gy	NOUN
eurjchem-596	290	17	with	with	ADP
eurjchem-596	290	18	a	a	DET
eurjchem-596	290	19	dose	dose	NOUN
eurjchem-596	290	20	rate	rate	NOUN
eurjchem-596	290	21	of	of	ADP
eurjchem-596	290	22	2	2	NUM
eurjchem-596	290	23	gy	gy	NOUN
eurjchem-596	290	24	/	/	SYM
eurjchem-596	290	25	min	min	PROPN
eurjchem-596	290	26	.	.	PROPN
eurjchem-596	290	27	irradition	irradition	NOUN
eurjchem-596	290	28	was	be	AUX
eurjchem-596	290	29	performed	perform	VERB
eurjchem-596	290	30	in	in	ADP
eurjchem-596	290	31	the	the	DET
eurjchem-596	290	32	national	national	PROPN
eurjchem-596	290	33	cancer	cancer	PROPN
eurjchem-596	290	34	institute	institute	PROPN
eurjchem-596	290	35	,	,	PUNCT
eurjchem-596	290	36	cairo	cairo	PROPN
eurjchem-596	290	37	university	university	PROPN
eurjchem-596	290	38	,	,	PUNCT
eurjchem-596	290	39	using	use	VERB
eurjchem-596	290	40	gamma	gamma	PROPN
eurjchem-596	290	41	cell‐	cell‐	PROPN
eurjchem-596	290	42	40	40	NUM
eurjchem-596	290	43	(	(	PUNCT
eurjchem-596	290	44	60co	60co	NOUN
eurjchem-596	290	45	)	)	PUNCT
eurjchem-596	290	46	source	source	NOUN
eurjchem-596	290	47	.	.	PUNCT
eurjchem-596	291	1	the	the	DET
eurjchem-596	291	2	surviving	survive	VERB
eurjchem-596	291	3	fractions	fraction	NOUN
eurjchem-596	291	4	were	be	AUX
eurjchem-596	291	5	expressed	express	VERB
eurjchem-596	291	6	as	as	SCONJ
eurjchem-596	291	7	means	mean	VERB
eurjchem-596	291	8	±	±	NUM
eurjchem-596	291	9	standard	standard	ADJ
eurjchem-596	291	10	error	error	NOUN
eurjchem-596	291	11	.	.	PUNCT
eurjchem-596	292	1	the	the	DET
eurjchem-596	292	2	results	result	NOUN
eurjchem-596	292	3	were	be	AUX
eurjchem-596	292	4	given	give	VERB
eurjchem-596	292	5	in	in	ADP
eurjchem-596	292	6	table	table	NOUN
eurjchem-596	292	7	3	3	NUM
eurjchem-596	292	8	.	.	NOUN
eurjchem-596	292	9	3	3	NUM
eurjchem-596	292	10	.	.	NOUN
eurjchem-596	292	11	results	result	NOUN
eurjchem-596	292	12	and	and	CCONJ
eurjchem-596	292	13	discussion	discussion	NOUN
eurjchem-596	292	14	3.1	3.1	NUM
eurjchem-596	292	15	.	.	PUNCT
eurjchem-596	293	1	chemistry	chemistry	NOUN
eurjchem-596	293	2	schemes	scheme	NOUN
eurjchem-596	293	3	1	1	NUM
eurjchem-596	293	4	and	and	CCONJ
eurjchem-596	293	5	2	2	NUM
eurjchem-596	293	6	outline	outline	NOUN
eurjchem-596	293	7	the	the	DET
eurjchem-596	293	8	synthetic	synthetic	ADJ
eurjchem-596	293	9	pathway	pathway	NOUN
eurjchem-596	293	10	used	use	VERB
eurjchem-596	293	11	to	to	PART
eurjchem-596	293	12	obtain	obtain	VERB
eurjchem-596	293	13	1,6‐dihydropyridines	1,6‐dihydropyridines	NUM
eurjchem-596	293	14	(	(	PUNCT
eurjchem-596	293	15	4a‐j	4a‐j	PROPN
eurjchem-596	293	16	)	)	PUNCT
eurjchem-596	293	17	,	,	PUNCT
eurjchem-596	293	18	1,2‐dihydroisoquinolines	1,2‐dihydroisoquinolines	NUM
eurjchem-596	293	19	(	(	PUNCT
eurjchem-596	293	20	6a‐h	6a‐h	NOUN
eurjchem-596	293	21	)	)	PUNCT
eurjchem-596	293	22	,	,	PUNCT
eurjchem-596	293	23	2h‐chromenes	2h‐chromenes	NUM
eurjchem-596	293	24	(	(	PUNCT
eurjchem-596	293	25	7	7	NUM
eurjchem-596	293	26	and	and	CCONJ
eurjchem-596	293	27	8)	8)	NUM
eurjchem-596	293	28	and	and	CCONJ
eurjchem-596	293	29	3h‐chromeno[3,4‐	3h‐chromeno[3,4‐	NUM
eurjchem-596	293	30	c]pyridines	c]pyridine	NOUN
eurjchem-596	293	31	(	(	PUNCT
eurjchem-596	293	32	9	9	NUM
eurjchem-596	293	33	and	and	CCONJ
eurjchem-596	293	34	10	10	NUM
eurjchem-596	293	35	)	)	PUNCT
eurjchem-596	293	36	.	.	PUNCT
eurjchem-596	294	1	the	the	DET
eurjchem-596	294	2	starting	starting	NOUN
eurjchem-596	294	3	material	material	NOUN
eurjchem-596	294	4	,	,	PUNCT
eurjchem-596	294	5	3‐cyano‐n‐(3‐	3‐cyano‐n‐(3‐	PRON
eurjchem-596	294	6	ethylphenyl	ethylphenyl	ADJ
eurjchem-596	294	7	)	)	PUNCT
eurjchem-596	294	8	acetamide	acetamide	NOUN
eurjchem-596	294	9	,	,	PUNCT
eurjchem-596	294	10	3	3	NUM
eurjchem-596	294	11	,	,	PUNCT
eurjchem-596	294	12	was	be	AUX
eurjchem-596	294	13	prepared	prepare	VERB
eurjchem-596	294	14	via	via	ADP
eurjchem-596	294	15	reaction	reaction	NOUN
eurjchem-596	294	16	of	of	ADP
eurjchem-596	294	17	3‐	3‐	NUM
eurjchem-596	294	18	ethylaniline	ethylaniline	NOUN
eurjchem-596	294	19	1	1	NUM
eurjchem-596	294	20	with	with	ADP
eurjchem-596	294	21	ethyl	ethyl	PROPN
eurjchem-596	294	22	cyanoacetate	cyanoacetate	NOUN
eurjchem-596	294	23	2	2	NUM
eurjchem-596	294	24	.	.	PUNCT
eurjchem-596	295	1	compound	compound	NOUN
eurjchem-596	295	2	3	3	NUM
eurjchem-596	295	3	was	be	AUX
eurjchem-596	295	4	confirmed	confirm	VERB
eurjchem-596	295	5	by	by	ADP
eurjchem-596	295	6	elemental	elemental	ADJ
eurjchem-596	295	7	analysis	analysis	NOUN
eurjchem-596	295	8	,	,	PUNCT
eurjchem-596	295	9	ir	ir	INTJ
eurjchem-596	295	10	,	,	PUNCT
eurjchem-596	295	11	1h	1h	NUM
eurjchem-596	295	12	nmr	nmr	NOUN
eurjchem-596	295	13	and	and	CCONJ
eurjchem-596	295	14	mass	mass	ADJ
eurjchem-596	295	15	spectral	spectral	ADJ
eurjchem-596	295	16	data	datum	NOUN
eurjchem-596	295	17	(	(	PUNCT
eurjchem-596	295	18	scheme	scheme	NOUN
eurjchem-596	295	19	1	1	NUM
eurjchem-596	295	20	)	)	PUNCT
eurjchem-596	295	21	.	.	PUNCT
eurjchem-596	296	1	upon	upon	SCONJ
eurjchem-596	296	2	treatment	treatment	NOUN
eurjchem-596	296	3	of	of	ADP
eurjchem-596	296	4	compound	compound	NOUN
eurjchem-596	296	5	3	3	NUM
eurjchem-596	296	6	with	with	ADP
eurjchem-596	296	7	required	require	VERB
eurjchem-596	296	8	aldehyde	aldehyde	NOUN
eurjchem-596	296	9	and	and	CCONJ
eurjchem-596	296	10	ethyl	ethyl	PROPN
eurjchem-596	296	11	cyanoacetate	cyanoacetate	NOUN
eurjchem-596	296	12	in	in	ADP
eurjchem-596	296	13	the	the	DET
eurjchem-596	296	14	presence	presence	NOUN
eurjchem-596	296	15	of	of	ADP
eurjchem-596	296	16	catalytic	catalytic	ADJ
eurjchem-596	296	17	amount	amount	NOUN
eurjchem-596	296	18	of	of	ADP
eurjchem-596	296	19	piperidine	piperidine	NOUN
eurjchem-596	296	20	furnished	furnish	VERB
eurjchem-596	296	21	ethyl	ethyl	PROPN
eurjchem-596	296	22	4‐substituted‐2‐amino‐5‐	4‐substituted‐2‐amino‐5‐	PROPN
eurjchem-596	296	23	cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐1,6‐dihydropyridine‐3‐	cyano‐1‐(3‐ethylphenyl)‐6‐oxo‐1,6‐dihydropyridine‐3‐	NOUN
eurjchem-596	296	24	carboxylate	carboxylate	NOUN
eurjchem-596	296	25	,	,	PUNCT
eurjchem-596	296	26	4a‐j	4a‐j	PROPN
eurjchem-596	296	27	.	.	PUNCT
eurjchem-596	297	1	the	the	DET
eurjchem-596	297	2	structure	structure	NOUN
eurjchem-596	297	3	of	of	ADP
eurjchem-596	297	4	compounds	compound	NOUN
eurjchem-596	297	5	4a‐j	4a‐j	PROPN
eurjchem-596	297	6	was	be	AUX
eurjchem-596	297	7	deduced	deduce	VERB
eurjchem-596	297	8	from	from	ADP
eurjchem-596	297	9	elemental	elemental	ADJ
eurjchem-596	297	10	analyses	analysis	NOUN
eurjchem-596	297	11	and	and	CCONJ
eurjchem-596	297	12	spectral	spectral	ADJ
eurjchem-596	297	13	data	datum	NOUN
eurjchem-596	297	14	(	(	PUNCT
eurjchem-596	297	15	scheme	scheme	NOUN
eurjchem-596	297	16	1	1	NUM
eurjchem-596	297	17	)	)	PUNCT
eurjchem-596	297	18	.	.	PUNCT
eurjchem-596	298	1	cycloaddition	cycloaddition	NOUN
eurjchem-596	298	2	occurred	occur	VERB
eurjchem-596	298	3	upon	upon	SCONJ
eurjchem-596	298	4	treatment	treatment	NOUN
eurjchem-596	298	5	of	of	ADP
eurjchem-596	298	6	compound	compound	NOUN
eurjchem-596	298	7	3	3	NUM
eurjchem-596	298	8	with	with	ADP
eurjchem-596	298	9	acetylacetone	acetylacetone	NOUN
eurjchem-596	298	10	to	to	PART
eurjchem-596	298	11	furnish	furnish	VERB
eurjchem-596	298	12	2‐pyridone	2‐pyridone	NUM
eurjchem-596	298	13	derivative	derivative	NOUN
eurjchem-596	298	14	5	5	NUM
eurjchem-596	298	15	which	which	PRON
eurjchem-596	298	16	upon	upon	SCONJ
eurjchem-596	298	17	reaction	reaction	NOUN
eurjchem-596	298	18	with	with	ADP
eurjchem-596	298	19	the	the	DET
eurjchem-596	298	20	corresponding	corresponding	ADJ
eurjchem-596	298	21	arylidinemalononitriles	arylidinemalononitrile	NOUN
eurjchem-596	298	22	yielded	yield	VERB
eurjchem-596	298	23	the	the	DET
eurjchem-596	298	24	correspondingisoquinoline	correspondingisoquinoline	NOUN
eurjchem-596	298	25	derivatives	derivative	NOUN
eurjchem-596	298	26	6a‐h	6a‐h	NOUN
eurjchem-596	298	27	(	(	PUNCT
eurjchem-596	298	28	scheme	scheme	NOUN
eurjchem-596	298	29	2	2	NUM
eurjchem-596	298	30	)	)	PUNCT
eurjchem-596	298	31	.	.	PUNCT
eurjchem-596	299	1	furthermore	furthermore	ADV
eurjchem-596	299	2	,	,	PUNCT
eurjchem-596	299	3	perkin	perkin	PROPN
eurjchem-596	299	4	reaction	reaction	NOUN
eurjchem-596	299	5	was	be	AUX
eurjchem-596	299	6	carried	carry	VERB
eurjchem-596	299	7	when	when	SCONJ
eurjchem-596	299	8	compound	compound	NOUN
eurjchem-596	299	9	3	3	NUM
eurjchem-596	299	10	was	be	AUX
eurjchem-596	299	11	reacted	react	VERB
eurjchem-596	299	12	with	with	ADP
eurjchem-596	299	13	salicyaldehyde	salicyaldehyde	NOUN
eurjchem-596	299	14	in	in	ADP
eurjchem-596	299	15	the	the	DET
eurjchem-596	299	16	presence	presence	NOUN
eurjchem-596	299	17	ofacetic	ofacetic	ADJ
eurjchem-596	299	18	anhydride	anhydride	NOUN
eurjchem-596	299	19	containing	contain	VERB
eurjchem-596	299	20	sodium	sodium	NOUN
eurjchem-596	299	21	acetate	acetate	NOUN
eurjchem-596	299	22	to	to	PART
eurjchem-596	299	23	give	give	VERB
eurjchem-596	299	24	the	the	DET
eurjchem-596	299	25	corresponding	correspond	VERB
eurjchem-596	299	26	2‐oxochromene	2‐oxochromene	ADJ
eurjchem-596	299	27	derivative	derivative	ADJ
eurjchem-596	299	28	7	7	NUM
eurjchem-596	299	29	,	,	PUNCT
eurjchem-596	299	30	while	while	SCONJ
eurjchem-596	299	31	reaction	reaction	NOUN
eurjchem-596	299	32	of	of	ADP
eurjchem-596	299	33	compound	compound	NOUN
eurjchem-596	299	34	3	3	NUM
eurjchem-596	299	35	with	with	ADP
eurjchem-596	299	36	saliclyaldehyde	saliclyaldehyde	NOUN
eurjchem-596	299	37	in	in	ADP
eurjchem-596	299	38	ammonium	ammonium	NOUN
eurjchem-596	299	39	acetate	acetate	NOUN
eurjchem-596	299	40	furnished	furnish	VERB
eurjchem-596	299	41	2‐	2‐	NUM
eurjchem-596	299	42	iminochromene	iminochromene	ADJ
eurjchem-596	299	43	8	8	NUM
eurjchem-596	299	44	.	.	PUNCT
eurjchem-596	300	1	the	the	DET
eurjchem-596	300	2	structure	structure	NOUN
eurjchem-596	300	3	of	of	ADP
eurjchem-596	300	4	compound	compound	NOUN
eurjchem-596	300	5	7	7	NUM
eurjchem-596	300	6	and	and	CCONJ
eurjchem-596	300	7	8	8	NUM
eurjchem-596	300	8	was	be	AUX
eurjchem-596	300	9	supported	support	VERB
eurjchem-596	300	10	in	in	ADP
eurjchem-596	300	11	the	the	DET
eurjchem-596	300	12	basis	basis	NOUN
eurjchem-596	300	13	of	of	ADP
eurjchem-596	300	14	elemental	elemental	ADJ
eurjchem-596	300	15	analyses	analysis	NOUN
eurjchem-596	300	16	,	,	PUNCT
eurjchem-596	300	17	ir	ir	INTJ
eurjchem-596	300	18	,	,	PUNCT
eurjchem-596	300	19	1h	1h	NUM
eurjchem-596	300	20	nmr	nmr	NOUN
eurjchem-596	300	21	and	and	CCONJ
eurjchem-596	300	22	mass	mass	ADJ
eurjchem-596	300	23	spectral	spectral	ADJ
eurjchem-596	300	24	data	datum	NOUN
eurjchem-596	300	25	.	.	PUNCT
eurjchem-596	301	1	the	the	DET
eurjchem-596	301	2	chromene	chromene	NOUN
eurjchem-596	301	3	derivative	derivative	ADJ
eurjchem-596	301	4	7	7	NUM
eurjchem-596	301	5	and	and	CCONJ
eurjchem-596	301	6	8	8	NUM
eurjchem-596	301	7	were	be	AUX
eurjchem-596	301	8	further	far	ADV
eurjchem-596	301	9	reacted	react	VERB
eurjchem-596	301	10	with	with	ADP
eurjchem-596	301	11	malononitrile	malononitrile	NOUN
eurjchem-596	301	12	in	in	ADP
eurjchem-596	301	13	the	the	DET
eurjchem-596	301	14	presence	presence	NOUN
eurjchem-596	301	15	of	of	ADP
eurjchem-596	301	16	ammonium	ammonium	NOUN
eurjchem-596	301	17	acetate	acetate	NOUN
eurjchem-596	301	18	to	to	PART
eurjchem-596	301	19	give	give	VERB
eurjchem-596	301	20	the	the	DET
eurjchem-596	301	21	corresponding	correspond	VERB
eurjchem-596	301	22	chromeno	chromeno	ADJ
eurjchem-596	301	23	pyridine	pyridine	NOUN
eurjchem-596	301	24	derivatives	derivative	NOUN
eurjchem-596	301	25	9	9	NUM
eurjchem-596	301	26	and	and	CCONJ
eurjchem-596	301	27	10	10	NUM
eurjchem-596	301	28	,	,	PUNCT
eurjchem-596	301	29	respectively	respectively	ADV
eurjchem-596	301	30	(	(	PUNCT
eurjchem-596	301	31	scheme	scheme	NOUN
eurjchem-596	301	32	3	3	NUM
eurjchem-596	301	33	)	)	PUNCT
eurjchem-596	301	34	.	.	PUNCT
eurjchem-596	302	1	the	the	DET
eurjchem-596	302	2	structure	structure	NOUN
eurjchem-596	302	3	of	of	ADP
eurjchem-596	302	4	compounds	compound	NOUN
eurjchem-596	302	5	9	9	NUM
eurjchem-596	302	6	and	and	CCONJ
eurjchem-596	302	7	10	10	NUM
eurjchem-596	302	8	was	be	AUX
eurjchem-596	302	9	elucidated	elucidate	VERB
eurjchem-596	302	10	from	from	ADP
eurjchem-596	302	11	elemental	elemental	ADJ
eurjchem-596	302	12	analyses	analysis	NOUN
eurjchem-596	302	13	and	and	CCONJ
eurjchem-596	302	14	spectral	spectral	ADJ
eurjchem-596	302	15	data	datum	NOUN
eurjchem-596	302	16	.	.	PUNCT
eurjchem-596	303	1	3.2	3.2	NUM
eurjchem-596	303	2	.	.	PUNCT
eurjchem-596	303	3	in‐vitro	in‐vitro	NOUN
eurjchem-596	303	4	anticancer	anticancer	NOUN
eurjchem-596	303	5	screening	screen	VERB
eurjchem-596	303	6	3.2.1	3.2.1	NUM
eurjchem-596	303	7	.	.	PUNCT
eurjchem-596	303	8	in‐vitro	in‐vitro	NOUN
eurjchem-596	303	9	anticancer	anticancer	NOUN
eurjchem-596	303	10	activity	activity	NOUN
eurjchem-596	303	11	using	use	VERB
eurjchem-596	303	12	ehrlich	ehrlich	PROPN
eurjchem-596	303	13	ascites	ascite	NOUN
eurjchem-596	303	14	carcinoma	carcinoma	NOUN
eurjchem-596	303	15	(	(	PUNCT
eurjchem-596	303	16	eac	eac	PROPN
eurjchem-596	303	17	)	)	PUNCT
eurjchem-596	303	18	cells	cell	NOUN
eurjchem-596	303	19	doxorubicin	doxorubicin	PROPN
eurjchem-596	303	20	,	,	PUNCT
eurjchem-596	303	21	the	the	DET
eurjchem-596	303	22	reference	reference	NOUN
eurjchem-596	303	23	drug	drug	NOUN
eurjchem-596	303	24	used	use	VERB
eurjchem-596	303	25	in	in	ADP
eurjchem-596	303	26	this	this	DET
eurjchem-596	303	27	study	study	NOUN
eurjchem-596	303	28	is	be	AUX
eurjchem-596	303	29	one	one	NUM
eurjchem-596	303	30	of	of	ADP
eurjchem-596	303	31	the	the	DET
eurjchem-596	303	32	most	most	ADV
eurjchem-596	303	33	effective	effective	ADJ
eurjchem-596	303	34	antitumor	antitumor	PROPN
eurjchem-596	303	35	agents	agent	NOUN
eurjchem-596	303	36	used	use	VERB
eurjchem-596	303	37	to	to	PART
eurjchem-596	303	38	produce	produce	VERB
eurjchem-596	303	39	regressions	regression	NOUN
eurjchem-596	303	40	in	in	ADP
eurjchem-596	303	41	acute	acute	ADJ
eurjchem-596	303	42	leukemia	leukemia	NOUN
eurjchem-596	303	43	’s	’s	PART
eurjchem-596	303	44	,	,	PUNCT
eurjchem-596	303	45	hodgkin	hodgkin	PROPN
eurjchem-596	303	46	’s	’s	PART
eurjchem-596	303	47	disease	disease	NOUN
eurjchem-596	303	48	,	,	PUNCT
eurjchem-596	303	49	and	and	CCONJ
eurjchem-596	303	50	other	other	ADJ
eurjchem-596	303	51	lymphomas	lymphoma	NOUN
eurjchem-596	303	52	.	.	PUNCT
eurjchem-596	304	1	the	the	DET
eurjchem-596	304	2	relationship	relationship	NOUN
eurjchem-596	304	3	between	between	ADP
eurjchem-596	304	4	survival	survival	NOUN
eurjchem-596	304	5	ratio	ratio	NOUN
eurjchem-596	304	6	and	and	CCONJ
eurjchem-596	304	7	drug	drug	NOUN
eurjchem-596	304	8	concentration	concentration	NOUN
eurjchem-596	304	9	was	be	AUX
eurjchem-596	304	10	plotted	plot	VERB
eurjchem-596	304	11	to	to	PART
eurjchem-596	304	12	obtain	obtain	VERB
eurjchem-596	304	13	the	the	DET
eurjchem-596	304	14	survival	survival	NOUN
eurjchem-596	304	15	curve	curve	NOUN
eurjchem-596	304	16	of	of	ADP
eurjchem-596	304	17	ehrlich	ehrlich	NOUN
eurjchem-596	304	18	ascites	ascite	NOUN
eurjchem-596	304	19	carcinoma	carcinoma	NOUN
eurjchem-596	304	20	(	(	PUNCT
eurjchem-596	304	21	eac	eac	PROPN
eurjchem-596	304	22	)	)	PUNCT
eurjchem-596	304	23	cells	cell	NOUN
eurjchem-596	304	24	and	and	CCONJ
eurjchem-596	304	25	human	human	ADJ
eurjchem-596	304	26	liver	liver	NOUN
eurjchem-596	304	27	cell	cell	NOUN
eurjchem-596	304	28	line	line	NOUN
eurjchem-596	304	29	(	(	PUNCT
eurjchem-596	304	30	hepg2	hepg2	NOUN
eurjchem-596	304	31	)	)	PUNCT
eurjchem-596	304	32	.	.	PUNCT
eurjchem-596	305	1	the	the	DET
eurjchem-596	305	2	response	response	NOUN
eurjchem-596	305	3	parameter	parameter	NOUN
eurjchem-596	305	4	calculated	calculate	VERB
eurjchem-596	305	5	was	be	AUX
eurjchem-596	305	6	ic50	ic50	PROPN
eurjchem-596	305	7	value	value	NOUN
eurjchem-596	305	8	(	(	PUNCT
eurjchem-596	305	9	tables	table	NOUN
eurjchem-596	305	10	1	1	NUM
eurjchem-596	305	11	and	and	CCONJ
eurjchem-596	305	12	2	2	NUM
eurjchem-596	305	13	)	)	PUNCT
eurjchem-596	305	14	,	,	PUNCT
eurjchem-596	305	15	which	which	PRON
eurjchem-596	305	16	corresponds	correspond	VERB
eurjchem-596	305	17	to	to	ADP
eurjchem-596	305	18	the	the	DET
eurjchem-596	305	19	compound	compound	NOUN
eurjchem-596	305	20	concentration	concentration	NOUN
eurjchem-596	305	21	causing	cause	VERB
eurjchem-596	305	22	50	50	NUM
eurjchem-596	305	23	%	%	NOUN
eurjchem-596	305	24	mortality	mortality	NOUN
eurjchem-596	305	25	in	in	ADP
eurjchem-596	305	26	net	net	ADJ
eurjchem-596	305	27	cells	cell	NOUN
eurjchem-596	305	28	.	.	PUNCT
eurjchem-596	306	1	3.2.2	3.2.2	NUM
eurjchem-596	306	2	.	.	PUNCT
eurjchem-596	306	3	structure	structure	NOUN
eurjchem-596	306	4	activity	activity	NOUN
eurjchem-596	306	5	relationship	relationship	NOUN
eurjchem-596	306	6	(	(	PUNCT
eurjchem-596	306	7	sar	sar	PROPN
eurjchem-596	306	8	)	)	PUNCT
eurjchem-596	306	9	the	the	DET
eurjchem-596	306	10	cytotoxicity	cytotoxicity	NOUN
eurjchem-596	306	11	of	of	ADP
eurjchem-596	306	12	twenty‐two	twenty‐two	NUM
eurjchem-596	306	13	compounds	compound	NOUN
eurjchem-596	306	14	was	be	AUX
eurjchem-596	306	15	examined	examine	VERB
eurjchem-596	306	16	on	on	ADP
eurjchem-596	306	17	ehrlich	ehrlich	PROPN
eurjchem-596	306	18	ascites	ascite	NOUN
eurjchem-596	306	19	carcinoma	carcinoma	NOUN
eurjchem-596	306	20	(	(	PUNCT
eurjchem-596	306	21	eac	eac	PROPN
eurjchem-596	306	22	)	)	PUNCT
eurjchem-596	306	23	cells	cell	NOUN
eurjchem-596	306	24	.	.	PUNCT
eurjchem-596	307	1	it	it	PRON
eurjchem-596	307	2	is	be	AUX
eurjchem-596	307	3	clear	clear	ADJ
eurjchem-596	307	4	from	from	ADP
eurjchem-596	307	5	the	the	DET
eurjchem-596	307	6	results	result	NOUN
eurjchem-596	307	7	in	in	ADP
eurjchem-596	307	8	(	(	PUNCT
eurjchem-596	307	9	table	table	NOUN
eurjchem-596	307	10	1	1	NUM
eurjchem-596	307	11	)	)	PUNCT
eurjchem-596	307	12	that	that	SCONJ
eurjchem-596	307	13	in	in	ADP
eurjchem-596	307	14	the	the	DET
eurjchem-596	307	15	series	series	NOUN
eurjchem-596	307	16	of	of	ADP
eurjchem-596	307	17	1,6‐dihydropyridine	1,6‐dihydropyridine	NUM
eurjchem-596	307	18	4a‐	4a‐	NUM
eurjchem-596	307	19	j	j	NOUN
eurjchem-596	307	20	,	,	PUNCT
eurjchem-596	307	21	the	the	DET
eurjchem-596	307	22	most	most	ADV
eurjchem-596	307	23	potent	potent	ADJ
eurjchem-596	307	24	in	in	ADP
eurjchem-596	307	25	this	this	DET
eurjchem-596	307	26	series	series	NOUN
eurjchem-596	307	27	is	be	AUX
eurjchem-596	307	28	the	the	DET
eurjchem-596	307	29	4‐methyl	4‐methyl	ADJ
eurjchem-596	307	30	derivative	derivative	ADJ
eurjchem-596	307	31	4a	4a	NOUN
eurjchem-596	307	32	(	(	PUNCT
eurjchem-596	307	33	ic50	ic50	PROPN
eurjchem-596	307	34	=	=	PROPN
eurjchem-596	307	35	62.34	62.34	NUM
eurjchem-596	307	36	µm	µm	NOUN
eurjchem-596	307	37	)	)	PUNCT
eurjchem-596	307	38	which	which	PRON
eurjchem-596	307	39	was	be	AUX
eurjchem-596	307	40	found	find	VERB
eurjchem-596	307	41	to	to	PART
eurjchem-596	307	42	be	be	AUX
eurjchem-596	307	43	more	more	ADV
eurjchem-596	307	44	potent	potent	ADJ
eurjchem-596	307	45	than	than	ADP
eurjchem-596	307	46	the	the	DET
eurjchem-596	307	47	reference	reference	NOUN
eurjchem-596	307	48	drug	drug	NOUN
eurjchem-596	307	49	(	(	PUNCT
eurjchem-596	307	50	ic50	ic50	PROPN
eurjchem-596	307	51	=	=	PROPN
eurjchem-596	307	52	68.13	68.13	NUM
eurjchem-596	307	53	µm	µm	NOUN
eurjchem-596	307	54	)	)	PUNCT
eurjchem-596	307	55	and	and	CCONJ
eurjchem-596	307	56	also	also	ADV
eurjchem-596	307	57	more	more	ADV
eurjchem-596	307	58	potent	potent	ADJ
eurjchem-596	307	59	than	than	ADP
eurjchem-596	307	60	the	the	DET
eurjchem-596	307	61	corresponding	correspond	VERB
eurjchem-596	307	62	4‐methoxy	4‐methoxy	ADJ
eurjchem-596	307	63	derivative	derivative	ADJ
eurjchem-596	307	64	4b	4b	NOUN
eurjchem-596	307	65	(	(	PUNCT
eurjchem-596	307	66	ic50	ic50	PROPN
eurjchem-596	307	67	=	=	PROPN
eurjchem-596	307	68	119.9	119.9	NUM
eurjchem-596	307	69	µm	µm	NOUN
eurjchem-596	307	70	)	)	PUNCT
eurjchem-596	307	71	and	and	CCONJ
eurjchem-596	307	72	the	the	DET
eurjchem-596	307	73	3‐ethoxy‐4‐methoxy	3‐ethoxy‐4‐methoxy	PROPN
eurjchem-596	307	74	derivative	derivative	ADJ
eurjchem-596	307	75	4f	4f	NUM
eurjchem-596	307	76	(	(	PUNCT
eurjchem-596	307	77	ic50	ic50	PROPN
eurjchem-596	307	78	=	=	PROPN
eurjchem-596	307	79	108.45	108.45	NUM
eurjchem-596	307	80	µm	µm	NOUN
eurjchem-596	307	81	)	)	PUNCT
eurjchem-596	307	82	and	and	CCONJ
eurjchem-596	307	83	is	be	AUX
eurjchem-596	307	84	nearly	nearly	ADV
eurjchem-596	307	85	as	as	ADV
eurjchem-596	307	86	potent	potent	ADJ
eurjchem-596	307	87	as	as	ADP
eurjchem-596	307	88	the	the	DET
eurjchem-596	307	89	trimethoxy	trimethoxy	PROPN
eurjchem-596	307	90	derivative	derivative	ADJ
eurjchem-596	307	91	4	4	NUM
eurjchem-596	307	92	g	g	NOUN
eurjchem-596	307	93	(	(	PUNCT
eurjchem-596	307	94	ic50	ic50	PROPN
eurjchem-596	307	95	=	=	PROPN
eurjchem-596	307	96	83.76	83.76	NUM
eurjchem-596	307	97	µm	µm	NOUN
eurjchem-596	307	98	)	)	PUNCT
eurjchem-596	307	99	.	.	PUNCT
eurjchem-596	308	1	on	on	ADP
eurjchem-596	308	2	the	the	DET
eurjchem-596	308	3	other	other	ADJ
eurjchem-596	308	4	hand	hand	NOUN
eurjchem-596	308	5	,	,	PUNCT
eurjchem-596	308	6	the	the	DET
eurjchem-596	308	7	4‐nitro	4‐nitro	NUM
eurjchem-596	308	8	derivative	derivative	ADJ
eurjchem-596	308	9	4d	4d	NOUN
eurjchem-596	308	10	(	(	PUNCT
eurjchem-596	308	11	ic50	ic50	PROPN
eurjchem-596	308	12	=	=	PROPN
eurjchem-596	308	13	57.87	57.87	NUM
eurjchem-596	308	14	µm	µm	NOUN
eurjchem-596	308	15	)	)	PUNCT
eurjchem-596	308	16	was	be	AUX
eurjchem-596	308	17	found	find	VERB
eurjchem-596	308	18	to	to	PART
eurjchem-596	308	19	be	be	AUX
eurjchem-596	308	20	more	more	ADV
eurjchem-596	308	21	potent	potent	ADJ
eurjchem-596	308	22	than	than	ADP
eurjchem-596	308	23	the	the	DET
eurjchem-596	308	24	corresponding	correspond	VERB
eurjchem-596	308	25	3‐nitro	3‐nitro	NUM
eurjchem-596	308	26	derivative	derivative	ADJ
eurjchem-596	308	27	4c	4c	NOUN
eurjchem-596	308	28	(	(	PUNCT
eurjchem-596	308	29	ic50	ic50	PROPN
eurjchem-596	308	30	=	=	PROPN
eurjchem-596	308	31	106.48	106.48	NUM
eurjchem-596	308	32	µm	µm	NOUN
eurjchem-596	308	33	)	)	PUNCT
eurjchem-596	308	34	,	,	PUNCT
eurjchem-596	308	35	finally	finally	ADV
eurjchem-596	308	36	,	,	PUNCT
eurjchem-596	308	37	the	the	DET
eurjchem-596	308	38	least	least	ADJ
eurjchem-596	308	39	potent	potent	ADJ
eurjchem-596	308	40	in	in	ADP
eurjchem-596	308	41	this	this	DET
eurjchem-596	308	42	series	series	NOUN
eurjchem-596	308	43	was	be	AUX
eurjchem-596	308	44	the	the	DET
eurjchem-596	308	45	halogenated	halogenated	ADJ
eurjchem-596	308	46	derivatives	derivative	NOUN
eurjchem-596	308	47	4h	4h	NOUN
eurjchem-596	308	48	and	and	CCONJ
eurjchem-596	308	49	4i	4i	NUM
eurjchem-596	308	50	(	(	PUNCT
eurjchem-596	308	51	ic50	ic50	PROPN
eurjchem-596	308	52	=	=	PROPN
eurjchem-596	308	53	116.38	116.38	NUM
eurjchem-596	308	54	and	and	CCONJ
eurjchem-596	308	55	105.15	105.15	NUM
eurjchem-596	308	56	µm	µm	NOUN
eurjchem-596	308	57	)	)	PUNCT
eurjchem-596	308	58	.	.	PUNCT
eurjchem-596	309	1	concerning	concern	VERB
eurjchem-596	309	2	the	the	DET
eurjchem-596	309	3	series	series	NOUN
eurjchem-596	309	4	of	of	ADP
eurjchem-596	309	5	1,2‐	1,2‐	NUM
eurjchem-596	309	6	dihydroisoquinoline	dihydroisoquinoline	NOUN
eurjchem-596	309	7	6a‐h	6a‐h	NOUN
eurjchem-596	309	8	,	,	PUNCT
eurjchem-596	309	9	the	the	DET
eurjchem-596	309	10	most	most	ADV
eurjchem-596	309	11	potent	potent	ADJ
eurjchem-596	309	12	in	in	ADP
eurjchem-596	309	13	this	this	DET
eurjchem-596	309	14	series	series	NOUN
eurjchem-596	309	15	is	be	AUX
eurjchem-596	309	16	the	the	DET
eurjchem-596	309	17	4‐methoxy	4‐methoxy	ADJ
eurjchem-596	309	18	derivative	derivative	ADJ
eurjchem-596	309	19	6c	6c	NOUN
eurjchem-596	309	20	(	(	PUNCT
eurjchem-596	309	21	ic50	ic50	PROPN
eurjchem-596	309	22	=	=	PROPN
eurjchem-596	309	23	36.67	36.67	NUM
eurjchem-596	309	24	µm	µm	NOUN
eurjchem-596	309	25	)	)	PUNCT
eurjchem-596	309	26	which	which	PRON
eurjchem-596	309	27	was	be	AUX
eurjchem-596	309	28	found	find	VERB
eurjchem-596	309	29	to	to	PART
eurjchem-596	309	30	be	be	AUX
eurjchem-596	309	31	more	more	ADV
eurjchem-596	309	32	potent	potent	ADJ
eurjchem-596	309	33	than	than	ADP
eurjchem-596	309	34	the	the	DET
eurjchem-596	309	35	reference	reference	NOUN
eurjchem-596	309	36	drug	drug	NOUN
eurjchem-596	309	37	(	(	PUNCT
eurjchem-596	309	38	ic50	ic50	PROPN
eurjchem-596	309	39	=	=	PROPN
eurjchem-596	309	40	68.13	68.13	NUM
eurjchem-596	309	41	µm	µm	NOUN
eurjchem-596	309	42	)	)	PUNCT
eurjchem-596	309	43	and	and	CCONJ
eurjchem-596	309	44	the	the	DET
eurjchem-596	309	45	corresponding	correspond	VERB
eurjchem-596	309	46	4‐methyl	4‐methyl	ADJ
eurjchem-596	309	47	derivative	derivative	ADJ
eurjchem-596	309	48	6a	6a	NOUN
eurjchem-596	309	49	(	(	PUNCT
eurjchem-596	309	50	ic50	ic50	PROPN
eurjchem-596	309	51	=	=	PROPN
eurjchem-596	309	52	58.52	58.52	NUM
eurjchem-596	309	53	µm	µm	NOUN
eurjchem-596	309	54	)	)	PUNCT
eurjchem-596	309	55	,	,	PUNCT
eurjchem-596	309	56	the	the	DET
eurjchem-596	309	57	trimethoxy	trimethoxy	PROPN
eurjchem-596	309	58	derivative	derivative	ADJ
eurjchem-596	309	59	6f	6f	NOUN
eurjchem-596	309	60	(	(	PUNCT
eurjchem-596	309	61	ic50	ic50	PROPN
eurjchem-596	309	62	=	=	PROPN
eurjchem-596	309	63	91.68	91.68	NUM
eurjchem-596	309	64	µm	µm	NOUN
eurjchem-596	309	65	)	)	PUNCT
eurjchem-596	309	66	and	and	CCONJ
eurjchem-596	309	67	the	the	DET
eurjchem-596	309	68	2‐methoxy	2‐methoxy	NUM
eurjchem-596	309	69	derivative	derivative	ADJ
eurjchem-596	309	70	6b	6b	NOUN
eurjchem-596	309	71	(	(	PUNCT
eurjchem-596	309	72	ic50	ic50	PROPN
eurjchem-596	309	73	=	=	PUNCT
eurjchem-596	309	74	244.5	244.5	NUM
eurjchem-596	309	75	µm	µm	NOUN
eurjchem-596	309	76	)	)	PUNCT
eurjchem-596	309	77	which	which	PRON
eurjchem-596	309	78	is	be	AUX
eurjchem-596	309	79	the	the	DET
eurjchem-596	309	80	least	least	ADJ
eurjchem-596	309	81	potent	potent	ADJ
eurjchem-596	309	82	in	in	ADP
eurjchem-596	309	83	this	this	DET
eurjchem-596	309	84	series	series	NOUN
eurjchem-596	309	85	.	.	PUNCT
eurjchem-596	310	1	on	on	ADP
eurjchem-596	310	2	the	the	DET
eurjchem-596	310	3	other	other	ADJ
eurjchem-596	310	4	hand	hand	NOUN
eurjchem-596	310	5	,	,	PUNCT
eurjchem-596	310	6	the	the	DET
eurjchem-596	310	7	4‐nitro	4‐nitro	NUM
eurjchem-596	310	8	derivative	derivative	ADJ
eurjchem-596	310	9	6e	6e	NOUN
eurjchem-596	310	10	(	(	PUNCT
eurjchem-596	310	11	ic50	ic50	PROPN
eurjchem-596	310	12	=	=	PROPN
eurjchem-596	310	13	58.96	58.96	NUM
eurjchem-596	310	14	µm	µm	NOUN
eurjchem-596	310	15	)	)	PUNCT
eurjchem-596	310	16	was	be	AUX
eurjchem-596	310	17	found	find	VERB
eurjchem-596	310	18	to	to	PART
eurjchem-596	310	19	be	be	AUX
eurjchem-596	310	20	more	more	ADV
eurjchem-596	310	21	potent	potent	ADJ
eurjchem-596	310	22	than	than	ADP
eurjchem-596	310	23	the	the	DET
eurjchem-596	310	24	corresponding	correspond	VERB
eurjchem-596	310	25	3‐nitro	3‐nitro	NUM
eurjchem-596	310	26	derivative	derivative	ADJ
eurjchem-596	310	27	6d	6d	NOUN
eurjchem-596	310	28	(	(	PUNCT
eurjchem-596	310	29	ic50	ic50	PROPN
eurjchem-596	310	30	=	=	PROPN
eurjchem-596	310	31	108.49	108.49	NUM
eurjchem-596	310	32	µm	µm	NOUN
eurjchem-596	310	33	)	)	PUNCT
eurjchem-596	310	34	,	,	PUNCT
eurjchem-596	310	35	while	while	SCONJ
eurjchem-596	310	36	,	,	PUNCT
eurjchem-596	310	37	the	the	DET
eurjchem-596	310	38	chloro	chloro	NOUN
eurjchem-596	310	39	derivatives	derivative	VERB
eurjchem-596	310	40	6	6	NUM
eurjchem-596	310	41	g	g	NOUN
eurjchem-596	310	42	and	and	CCONJ
eurjchem-596	310	43	6h	6h	NUM
eurjchem-596	310	44	showed	show	VERB
eurjchem-596	310	45	nearly	nearly	ADV
eurjchem-596	310	46	equipotent	equipotent	NOUN
eurjchem-596	310	47	activity	activity	NOUN
eurjchem-596	310	48	(	(	PUNCT
eurjchem-596	310	49	ic50	ic50	PROPN
eurjchem-596	310	50	=	=	PROPN
eurjchem-596	310	51	121.06	121.06	NUM
eurjchem-596	310	52	and	and	CCONJ
eurjchem-596	310	53	107.14	107.14	NUM
eurjchem-596	310	54	µm	µm	NOUN
eurjchem-596	310	55	)	)	PUNCT
eurjchem-596	310	56	.	.	PUNCT
eurjchem-596	311	1	finally	finally	ADV
eurjchem-596	311	2	,	,	PUNCT
eurjchem-596	311	3	the	the	DET
eurjchem-596	311	4	chromeno[3,4‐c]pyridone	chromeno[3,4‐c]pyridone	NOUN
eurjchem-596	311	5	derivatives	derivative	NOUN
eurjchem-596	311	6	9	9	NUM
eurjchem-596	311	7	and	and	CCONJ
eurjchem-596	311	8	10	10	NUM
eurjchem-596	311	9	(	(	PUNCT
eurjchem-596	311	10	ic50	ic50	PROPN
eurjchem-596	311	11	=	=	PROPN
eurjchem-596	311	12	123.24	123.24	NUM
eurjchem-596	311	13	and	and	CCONJ
eurjchem-596	311	14	58.98	58.98	NUM
eurjchem-596	311	15	µm	µm	NOUN
eurjchem-596	311	16	)	)	PUNCT
eurjchem-596	311	17	showed	show	VERB
eurjchem-596	311	18	more	more	ADV
eurjchem-596	311	19	potent	potent	ADJ
eurjchem-596	311	20	activity	activity	NOUN
eurjchem-596	311	21	than	than	ADP
eurjchem-596	311	22	the	the	DET
eurjchem-596	311	23	corresponding	corresponding	ADJ
eurjchem-596	311	24	chromene	chromene	NOUN
eurjchem-596	311	25	derivatives	derivative	NOUN
eurjchem-596	311	26	7	7	NUM
eurjchem-596	311	27	and	and	CCONJ
eurjchem-596	311	28	8	8	NUM
eurjchem-596	311	29	which	which	PRON
eurjchem-596	311	30	showed	show	VERB
eurjchem-596	311	31	no	no	DET
eurjchem-596	311	32	ic50	ic50	PROPN
eurjchem-596	311	33	.	.	PUNCT
eurjchem-596	312	1	234	234	NUM
eurjchem-596	312	2	al‐said	al‐said	VERB
eurjchem-596	312	3	et	et	PROPN
eurjchem-596	312	4	al	al	PROPN
eurjchem-596	312	5	.	.	PUNCT
eurjchem-596	312	6	/	/	SYM
eurjchem-596	312	7	european	european	PROPN
eurjchem-596	312	8	journal	journal	PROPN
eurjchem-596	312	9	of	of	ADP
eurjchem-596	312	10	chemistry	chemistry	NOUN
eurjchem-596	312	11	3	3	NUM
eurjchem-596	312	12	(	(	PUNCT
eurjchem-596	312	13	2	2	NUM
eurjchem-596	312	14	)	)	PUNCT
eurjchem-596	312	15	(	(	PUNCT
eurjchem-596	312	16	2012	2012	NUM
eurjchem-596	312	17	)	)	PUNCT
eurjchem-596	312	18	228‐234	228‐234	PROPN
eurjchem-596	312	19	3.2.3	3.2.3	NUM
eurjchem-596	312	20	.	.	PUNCT
eurjchem-596	312	21	in‐vitro	in‐vitro	NOUN
eurjchem-596	312	22	anticancer	anticancer	NOUN
eurjchem-596	312	23	activity	activity	NOUN
eurjchem-596	312	24	using	use	VERB
eurjchem-596	312	25	liver	liver	NOUN
eurjchem-596	312	26	human	human	ADJ
eurjchem-596	312	27	tumor	tumor	NOUN
eurjchem-596	312	28	cell	cell	NOUN
eurjchem-596	312	29	lines	line	NOUN
eurjchem-596	312	30	(	(	PUNCT
eurjchem-596	312	31	hepg2	hepg2	VERB
eurjchem-596	312	32	)	)	PUNCT
eurjchem-596	312	33	this	this	DET
eurjchem-596	312	34	study	study	NOUN
eurjchem-596	312	35	was	be	AUX
eurjchem-596	312	36	performed	perform	VERB
eurjchem-596	312	37	to	to	PART
eurjchem-596	312	38	evaluate	evaluate	VERB
eurjchem-596	312	39	the	the	DET
eurjchem-596	312	40	cytotoxic	cytotoxic	ADJ
eurjchem-596	312	41	activity	activity	NOUN
eurjchem-596	312	42	of	of	ADP
eurjchem-596	312	43	the	the	DET
eurjchem-596	312	44	most	most	ADV
eurjchem-596	312	45	potent	potent	ADJ
eurjchem-596	312	46	six	six	NUM
eurjchem-596	312	47	compounds	compound	NOUN
eurjchem-596	312	48	resulted	result	VERB
eurjchem-596	312	49	from	from	ADP
eurjchem-596	312	50	eac	eac	PROPN
eurjchem-596	312	51	assay	assay	PROPN
eurjchem-596	312	52	(	(	PUNCT
eurjchem-596	312	53	compounds	compound	NOUN
eurjchem-596	312	54	4a	4a	NUM
eurjchem-596	312	55	,	,	PUNCT
eurjchem-596	312	56	4d	4d	NUM
eurjchem-596	312	57	,	,	PUNCT
eurjchem-596	312	58	6a	6a	NOUN
eurjchem-596	312	59	,	,	PUNCT
eurjchem-596	312	60	6c	6c	NOUN
eurjchem-596	312	61	,	,	PUNCT
eurjchem-596	312	62	6e	6e	NUM
eurjchem-596	312	63	and	and	CCONJ
eurjchem-596	312	64	10	10	NUM
eurjchem-596	312	65	)	)	PUNCT
eurjchem-596	312	66	.	.	PUNCT
eurjchem-596	313	1	we	we	PRON
eurjchem-596	313	2	can	can	AUX
eurjchem-596	313	3	conclude	conclude	VERB
eurjchem-596	313	4	from	from	ADP
eurjchem-596	313	5	the	the	DET
eurjchem-596	313	6	results	result	NOUN
eurjchem-596	313	7	obtained	obtain	VERB
eurjchem-596	313	8	from	from	ADP
eurjchem-596	313	9	(	(	PUNCT
eurjchem-596	313	10	table	table	NOUN
eurjchem-596	313	11	2	2	NUM
eurjchem-596	313	12	)	)	PUNCT
eurjchem-596	313	13	that	that	SCONJ
eurjchem-596	313	14	indeed	indeed	ADV
eurjchem-596	313	15	these	these	DET
eurjchem-596	313	16	compounds	compound	NOUN
eurjchem-596	313	17	showed	show	VERB
eurjchem-596	313	18	potent	potent	ADJ
eurjchem-596	313	19	activity	activity	NOUN
eurjchem-596	313	20	on	on	ADP
eurjchem-596	313	21	hepg2	hepg2	NOUN
eurjchem-596	313	22	cell	cell	NOUN
eurjchem-596	313	23	line	line	NOUN
eurjchem-596	313	24	.	.	PUNCT
eurjchem-596	314	1	the	the	DET
eurjchem-596	314	2	most	most	ADV
eurjchem-596	314	3	potent	potent	ADJ
eurjchem-596	314	4	was	be	AUX
eurjchem-596	314	5	the	the	DET
eurjchem-596	314	6	4‐nitro	4‐nitro	NUM
eurjchem-596	314	7	dihydropyridone	dihydropyridone	NOUN
eurjchem-596	314	8	derivative	derivative	ADJ
eurjchem-596	314	9	4d	4d	NOUN
eurjchem-596	314	10	(	(	PUNCT
eurjchem-596	314	11	ic50	ic50	PROPN
eurjchem-596	314	12	=	=	PROPN
eurjchem-596	314	13	11.7	11.7	NUM
eurjchem-596	314	14	µm	µm	NOUN
eurjchem-596	314	15	)	)	PUNCT
eurjchem-596	314	16	which	which	PRON
eurjchem-596	314	17	is	be	AUX
eurjchem-596	314	18	more	more	ADV
eurjchem-596	314	19	potent	potent	ADJ
eurjchem-596	314	20	than	than	ADP
eurjchem-596	314	21	doxorubicin	doxorubicin	PROPN
eurjchem-596	314	22	(	(	PUNCT
eurjchem-596	314	23	ic50	ic50	PROPN
eurjchem-596	314	24	=	=	PROPN
eurjchem-596	314	25	38.46	38.46	NUM
eurjchem-596	314	26	µm	µm	NOUN
eurjchem-596	314	27	)	)	PUNCT
eurjchem-596	314	28	,	,	PUNCT
eurjchem-596	314	29	while	while	SCONJ
eurjchem-596	314	30	,	,	PUNCT
eurjchem-596	314	31	the	the	DET
eurjchem-596	314	32	increasing	increase	VERB
eurjchem-596	314	33	order	order	NOUN
eurjchem-596	314	34	of	of	ADP
eurjchem-596	314	35	the	the	DET
eurjchem-596	314	36	rest	rest	NOUN
eurjchem-596	314	37	of	of	ADP
eurjchem-596	314	38	the	the	DET
eurjchem-596	314	39	compounds	compound	NOUN
eurjchem-596	314	40	was	be	AUX
eurjchem-596	314	41	as	as	SCONJ
eurjchem-596	314	42	follows	follow	VERB
eurjchem-596	314	43	:	:	PUNCT
eurjchem-596	314	44	4‐methyl	4‐methyl	ADV
eurjchem-596	314	45	isoquinoline	isoquinoline	VERB
eurjchem-596	314	46	derivative	derivative	ADJ
eurjchem-596	314	47	6a	6a	NOUN
eurjchem-596	314	48	(	(	PUNCT
eurjchem-596	314	49	ic50	ic50	PROPN
eurjchem-596	314	50	=	=	PROPN
eurjchem-596	314	51	21.81	21.81	NUM
eurjchem-596	314	52	µm	µm	NOUN
eurjchem-596	314	53	)	)	PUNCT
eurjchem-596	314	54	,	,	PUNCT
eurjchem-596	314	55	the	the	DET
eurjchem-596	314	56	4‐nitro	4‐nitro	NUM
eurjchem-596	314	57	isoquinoline	isoquinoline	ADJ
eurjchem-596	314	58	derivative	derivative	ADJ
eurjchem-596	314	59	6e	6e	NOUN
eurjchem-596	314	60	(	(	PUNCT
eurjchem-596	314	61	ic50	ic50	PROPN
eurjchem-596	314	62	=	=	PROPN
eurjchem-596	314	63	25.83	25.83	NUM
eurjchem-596	314	64	µm	µm	NOUN
eurjchem-596	314	65	)	)	PUNCT
eurjchem-596	314	66	,	,	PUNCT
eurjchem-596	314	67	the	the	DET
eurjchem-596	314	68	4‐methyl	4‐methyl	PROPN
eurjchem-596	314	69	dihydropyridone	dihydropyridone	NOUN
eurjchem-596	314	70	derivative	derivative	ADJ
eurjchem-596	314	71	4a	4a	NOUN
eurjchem-596	314	72	(	(	PUNCT
eurjchem-596	314	73	ic50	ic50	PROPN
eurjchem-596	314	74	=	=	PROPN
eurjchem-596	314	75	31.2	31.2	NUM
eurjchem-596	314	76	µm	µm	NUM
eurjchem-596	314	77	)	)	PUNCT
eurjchem-596	314	78	,	,	PUNCT
eurjchem-596	314	79	the	the	DET
eurjchem-596	314	80	chromeno[3,4‐c]pyridine	chromeno[3,4‐c]pyridine	NOUN
eurjchem-596	314	81	10	10	NUM
eurjchem-596	314	82	(	(	PUNCT
eurjchem-596	314	83	ic50	ic50	PROPN
eurjchem-596	314	84	=	=	PROPN
eurjchem-596	314	85	32.2	32.2	NUM
eurjchem-596	314	86	µm	µm	NOUN
eurjchem-596	314	87	)	)	PUNCT
eurjchem-596	314	88	and	and	CCONJ
eurjchem-596	314	89	the	the	DET
eurjchem-596	314	90	4‐methoxy	4‐methoxy	PROPN
eurjchem-596	314	91	isoquinoline	isoquinoline	ADJ
eurjchem-596	314	92	6c	6c	NOUN
eurjchem-596	314	93	(	(	PUNCT
eurjchem-596	314	94	ic50	ic50	PROPN
eurjchem-596	314	95	=	=	PROPN
eurjchem-596	314	96	38.9	38.9	NUM
eurjchem-596	314	97	µm	µm	NOUN
eurjchem-596	314	98	)	)	PUNCT
eurjchem-596	314	99	.	.	PUNCT
eurjchem-596	315	1	3.3	3.3	NUM
eurjchem-596	315	2	.	.	PUNCT
eurjchem-596	316	1	radiosensitizing	radiosensitize	VERB
eurjchem-596	316	2	evaluation	evaluation	NOUN
eurjchem-596	316	3	the	the	DET
eurjchem-596	316	4	rationale	rationale	NOUN
eurjchem-596	316	5	for	for	ADP
eurjchem-596	316	6	combining	combine	VERB
eurjchem-596	316	7	chemotherapy	chemotherapy	NOUN
eurjchem-596	316	8	and	and	CCONJ
eurjchem-596	316	9	radiotherapy	radiotherapy	NOUN
eurjchem-596	316	10	is	be	AUX
eurjchem-596	316	11	based	base	VERB
eurjchem-596	316	12	mainly	mainly	ADV
eurjchem-596	316	13	on	on	ADP
eurjchem-596	316	14	two	two	NUM
eurjchem-596	316	15	ideas	idea	NOUN
eurjchem-596	316	16	,	,	PUNCT
eurjchem-596	316	17	one	one	NUM
eurjchem-596	316	18	being	be	AUX
eurjchem-596	316	19	spatial	spatial	ADJ
eurjchem-596	316	20	cooperation	cooperation	NOUN
eurjchem-596	316	21	,	,	PUNCT
eurjchem-596	316	22	which	which	PRON
eurjchem-596	316	23	is	be	AUX
eurjchem-596	316	24	effective	effective	ADJ
eurjchem-596	316	25	if	if	SCONJ
eurjchem-596	316	26	chemotherapy	chemotherapy	NOUN
eurjchem-596	316	27	is	be	AUX
eurjchem-596	316	28	sufficient	sufficient	ADJ
eurjchem-596	316	29	to	to	PART
eurjchem-596	316	30	eradicate	eradicate	VERB
eurjchem-596	316	31	subclinical	subclinical	ADJ
eurjchem-596	316	32	metastases	metastasis	NOUN
eurjchem-596	316	33	and	and	CCONJ
eurjchem-596	316	34	if	if	SCONJ
eurjchem-596	316	35	the	the	DET
eurjchem-596	316	36	primary	primary	ADJ
eurjchem-596	316	37	local	local	ADJ
eurjchem-596	316	38	tumor	tumor	NOUN
eurjchem-596	316	39	is	be	AUX
eurjchem-596	316	40	effectively	effectively	ADV
eurjchem-596	316	41	treated	treat	VERB
eurjchem-596	316	42	by	by	ADP
eurjchem-596	316	43	radiotherapy	radiotherapy	NOUN
eurjchem-596	316	44	.	.	PUNCT
eurjchem-596	317	1	in	in	ADP
eurjchem-596	317	2	this	this	DET
eurjchem-596	317	3	regard	regard	NOUN
eurjchem-596	317	4	,	,	PUNCT
eurjchem-596	317	5	no	no	DET
eurjchem-596	317	6	interaction	interaction	NOUN
eurjchem-596	317	7	between	between	ADP
eurjchem-596	317	8	radiotherapy	radiotherapy	NOUN
eurjchem-596	317	9	and	and	CCONJ
eurjchem-596	317	10	chemotherapy	chemotherapy	NOUN
eurjchem-596	317	11	is	be	AUX
eurjchem-596	317	12	required	require	VERB
eurjchem-596	317	13	.	.	PUNCT
eurjchem-596	318	1	the	the	DET
eurjchem-596	318	2	other	other	ADJ
eurjchem-596	318	3	idea	idea	NOUN
eurjchem-596	318	4	is	be	AUX
eurjchem-596	318	5	the	the	DET
eurjchem-596	318	6	enhancement	enhancement	NOUN
eurjchem-596	318	7	of	of	ADP
eurjchem-596	318	8	radiation	radiation	NOUN
eurjchem-596	318	9	effects	effect	NOUN
eurjchem-596	318	10	.	.	PUNCT
eurjchem-596	319	1	cytotoxic	cytotoxic	ADJ
eurjchem-596	319	2	agents	agent	NOUN
eurjchem-596	319	3	can	can	AUX
eurjchem-596	319	4	enhance	enhance	VERB
eurjchem-596	319	5	radiation	radiation	NOUN
eurjchem-596	319	6	effects	effect	NOUN
eurjchem-596	319	7	by	by	ADP
eurjchem-596	319	8	direct	direct	ADJ
eurjchem-596	319	9	enhancement	enhancement	NOUN
eurjchem-596	319	10	of	of	ADP
eurjchem-596	319	11	the	the	DET
eurjchem-596	319	12	initial	initial	ADJ
eurjchem-596	319	13	radiation	radiation	NOUN
eurjchem-596	319	14	damage	damage	NOUN
eurjchem-596	319	15	by	by	ADP
eurjchem-596	319	16	incorporating	incorporate	VERB
eurjchem-596	319	17	drugs	drug	NOUN
eurjchem-596	319	18	into	into	ADP
eurjchem-596	319	19	dna	dna	PROPN
eurjchem-596	319	20	,	,	PUNCT
eurjchem-596	319	21	inhibiting	inhibit	VERB
eurjchem-596	319	22	cellular	cellular	ADJ
eurjchem-596	319	23	repair	repair	NOUN
eurjchem-596	319	24	,	,	PUNCT
eurjchem-596	319	25	accumulating	accumulate	VERB
eurjchem-596	319	26	cells	cell	NOUN
eurjchem-596	319	27	in	in	ADP
eurjchem-596	319	28	a	a	DET
eurjchem-596	319	29	radiosensitive	radiosensitive	ADJ
eurjchem-596	319	30	phase	phase	NOUN
eurjchem-596	319	31	or	or	CCONJ
eurjchem-596	319	32	eliminating	eliminate	VERB
eurjchem-596	319	33	radioresistant	radioresistant	ADJ
eurjchem-596	319	34	phase	phase	NOUN
eurjchem-596	319	35	cells	cell	NOUN
eurjchem-596	319	36	,	,	PUNCT
eurjchem-596	319	37	eliminating	eliminate	VERB
eurjchem-596	319	38	hypoxic	hypoxic	ADJ
eurjchem-596	319	39	cells	cell	NOUN
eurjchem-596	319	40	or	or	CCONJ
eurjchem-596	319	41	inhibiting	inhibit	VERB
eurjchem-596	319	42	the	the	DET
eurjchem-596	319	43	accelerated	accelerated	ADJ
eurjchem-596	319	44	repopulation	repopulation	NOUN
eurjchem-596	319	45	of	of	ADP
eurjchem-596	319	46	tumor	tumor	NOUN
eurjchem-596	319	47	cells	cell	NOUN
eurjchem-596	319	48	[	[	X
eurjchem-596	319	49	17	17	NUM
eurjchem-596	319	50	]	]	PUNCT
eurjchem-596	319	51	.	.	PUNCT
eurjchem-596	320	1	consequently	consequently	ADV
eurjchem-596	320	2	,	,	PUNCT
eurjchem-596	320	3	the	the	DET
eurjchem-596	320	4	ability	ability	NOUN
eurjchem-596	320	5	of	of	ADP
eurjchem-596	320	6	the	the	DET
eurjchem-596	320	7	most	most	ADV
eurjchem-596	320	8	six	six	NUM
eurjchem-596	320	9	active	active	ADJ
eurjchem-596	320	10	compounds	compound	NOUN
eurjchem-596	320	11	4a	4a	NOUN
eurjchem-596	320	12	,	,	PUNCT
eurjchem-596	320	13	4d	4d	NUM
eurjchem-596	320	14	,	,	PUNCT
eurjchem-596	320	15	6a	6a	NOUN
eurjchem-596	320	16	,	,	PUNCT
eurjchem-596	320	17	6c	6c	NOUN
eurjchem-596	320	18	,	,	PUNCT
eurjchem-596	320	19	6e	6e	NUM
eurjchem-596	320	20	and	and	CCONJ
eurjchem-596	320	21	10	10	NUM
eurjchem-596	320	22	,	,	PUNCT
eurjchem-596	320	23	to	to	PART
eurjchem-596	320	24	enhance	enhance	VERB
eurjchem-596	320	25	the	the	DET
eurjchem-596	320	26	cell	cell	NOUN
eurjchem-596	320	27	killing	killing	NOUN
eurjchem-596	320	28	effect	effect	NOUN
eurjchem-596	320	29	of	of	ADP
eurjchem-596	320	30	γ‐irradiation	γ‐irradiation	NUM
eurjchem-596	320	31	was	be	AUX
eurjchem-596	320	32	studied	study	VERB
eurjchem-596	320	33	.	.	PUNCT
eurjchem-596	321	1	from	from	ADP
eurjchem-596	321	2	the	the	DET
eurjchem-596	321	3	results	result	NOUN
eurjchem-596	321	4	obtained	obtain	VERB
eurjchem-596	321	5	in	in	ADP
eurjchem-596	321	6	(	(	PUNCT
eurjchem-596	321	7	table	table	NOUN
eurjchem-596	321	8	2	2	NUM
eurjchem-596	321	9	)	)	PUNCT
eurjchem-596	321	10	,	,	PUNCT
eurjchem-596	321	11	compound	compound	NOUN
eurjchem-596	321	12	4a	4a	NOUN
eurjchem-596	321	13	showed	show	VERB
eurjchem-596	321	14	an	an	DET
eurjchem-596	321	15	in	in	X
eurjchem-596	321	16	vitro	vitro	X
eurjchem-596	321	17	cytotoxic	cytotoxic	ADJ
eurjchem-596	321	18	activity	activity	NOUN
eurjchem-596	321	19	with	with	ADP
eurjchem-596	321	20	ic50	ic50	PROPN
eurjchem-596	321	21	value	value	NOUN
eurjchem-596	321	22	of	of	ADP
eurjchem-596	321	23	31.2	31.2	NUM
eurjchem-596	321	24	μm	μm	NOUN
eurjchem-596	321	25	,	,	PUNCT
eurjchem-596	321	26	when	when	SCONJ
eurjchem-596	321	27	the	the	DET
eurjchem-596	321	28	cells	cell	NOUN
eurjchem-596	321	29	were	be	AUX
eurjchem-596	321	30	subjected	subject	VERB
eurjchem-596	321	31	to	to	ADP
eurjchem-596	321	32	different	different	ADJ
eurjchem-596	321	33	concentrations	concentration	NOUN
eurjchem-596	321	34	of	of	ADP
eurjchem-596	321	35	the	the	DET
eurjchem-596	321	36	compound	compound	NOUN
eurjchem-596	321	37	alone	alone	ADV
eurjchem-596	321	38	.	.	PUNCT
eurjchem-596	322	1	while	while	SCONJ
eurjchem-596	322	2	,	,	PUNCT
eurjchem-596	322	3	when	when	SCONJ
eurjchem-596	322	4	the	the	DET
eurjchem-596	322	5	cells	cell	NOUN
eurjchem-596	322	6	were	be	AUX
eurjchem-596	322	7	subjected	subject	VERB
eurjchem-596	322	8	to	to	ADP
eurjchem-596	322	9	the	the	DET
eurjchem-596	322	10	same	same	ADJ
eurjchem-596	322	11	concentrations	concentration	NOUN
eurjchem-596	322	12	of	of	ADP
eurjchem-596	322	13	compound	compound	NOUN
eurjchem-596	322	14	4a	4a	NOUN
eurjchem-596	322	15	,	,	PUNCT
eurjchem-596	322	16	and	and	CCONJ
eurjchem-596	322	17	irradiated	irradiate	VERB
eurjchem-596	322	18	with	with	ADP
eurjchem-596	322	19	a	a	DET
eurjchem-596	322	20	single	single	ADJ
eurjchem-596	322	21	dose	dose	NOUN
eurjchem-596	322	22	of	of	ADP
eurjchem-596	322	23	γ‐radiation	γ‐radiation	PUNCT
eurjchem-596	322	24	at	at	ADP
eurjchem-596	322	25	a	a	DET
eurjchem-596	322	26	dose	dose	ADJ
eurjchem-596	322	27	level	level	NOUN
eurjchem-596	322	28	of	of	ADP
eurjchem-596	322	29	8	8	NUM
eurjchem-596	322	30	gy	gy	NOUN
eurjchem-596	322	31	,	,	PUNCT
eurjchem-596	322	32	as	as	SCONJ
eurjchem-596	322	33	shown	show	VERB
eurjchem-596	322	34	in	in	ADP
eurjchem-596	322	35	(	(	PUNCT
eurjchem-596	322	36	table	table	NOUN
eurjchem-596	322	37	3	3	NUM
eurjchem-596	322	38	)	)	PUNCT
eurjchem-596	322	39	,	,	PUNCT
eurjchem-596	322	40	the	the	DET
eurjchem-596	322	41	ic50	ic50	PROPN
eurjchem-596	322	42	value	value	NOUN
eurjchem-596	322	43	was	be	AUX
eurjchem-596	322	44	synergistically	synergistically	ADV
eurjchem-596	322	45	decreased	decrease	VERB
eurjchem-596	322	46	to	to	ADP
eurjchem-596	322	47	5.03	5.03	NUM
eurjchem-596	322	48	μm	μm	NOUN
eurjchem-596	322	49	.	.	PUNCT
eurjchem-596	323	1	similarly	similarly	ADV
eurjchem-596	323	2	,	,	PUNCT
eurjchem-596	323	3	compounds	compound	VERB
eurjchem-596	323	4	4d	4d	NUM
eurjchem-596	323	5	,	,	PUNCT
eurjchem-596	323	6	6a	6a	NOUN
eurjchem-596	323	7	,	,	PUNCT
eurjchem-596	323	8	6c	6c	NOUN
eurjchem-596	323	9	,	,	PUNCT
eurjchem-596	323	10	6e	6e	NUM
eurjchem-596	323	11	and	and	CCONJ
eurjchem-596	323	12	10	10	NUM
eurjchem-596	323	13	showed	show	VERB
eurjchem-596	323	14	ic50	ic50	PROPN
eurjchem-596	323	15	values	value	NOUN
eurjchem-596	323	16	of	of	ADP
eurjchem-596	323	17	11.7	11.7	NUM
eurjchem-596	323	18	,	,	PUNCT
eurjchem-596	323	19	21.81	21.81	NUM
eurjchem-596	323	20	,	,	PUNCT
eurjchem-596	323	21	38.9	38.9	NUM
eurjchem-596	323	22	,	,	PUNCT
eurjchem-596	323	23	25.83	25.83	NUM
eurjchem-596	323	24	and	and	CCONJ
eurjchem-596	323	25	32.2	32.2	NUM
eurjchem-596	323	26	μm	μm	NUM
eurjchem-596	323	27	,	,	PUNCT
eurjchem-596	323	28	respectively	respectively	ADV
eurjchem-596	323	29	,	,	PUNCT
eurjchem-596	323	30	when	when	SCONJ
eurjchem-596	323	31	used	use	VERB
eurjchem-596	323	32	alone	alone	ADV
eurjchem-596	323	33	,	,	PUNCT
eurjchem-596	323	34	as	as	SCONJ
eurjchem-596	323	35	shown	show	VERB
eurjchem-596	323	36	in	in	ADP
eurjchem-596	323	37	(	(	PUNCT
eurjchem-596	323	38	table	table	NOUN
eurjchem-596	323	39	2	2	NUM
eurjchem-596	323	40	)	)	PUNCT
eurjchem-596	323	41	.	.	PUNCT
eurjchem-596	324	1	the	the	DET
eurjchem-596	324	2	ic50	ic50	PROPN
eurjchem-596	324	3	value	value	NOUN
eurjchem-596	324	4	was	be	AUX
eurjchem-596	324	5	decreased	decrease	VERB
eurjchem-596	324	6	to	to	ADP
eurjchem-596	324	7	6.37	6.37	NUM
eurjchem-596	324	8	,	,	PUNCT
eurjchem-596	324	9	2.68	2.68	NUM
eurjchem-596	324	10	,	,	PUNCT
eurjchem-596	324	11	8.38	8.38	NUM
eurjchem-596	324	12	,	,	PUNCT
eurjchem-596	324	13	6.04	6.04	NUM
eurjchem-596	324	14	and	and	CCONJ
eurjchem-596	324	15	3.35	3.35	NUM
eurjchem-596	324	16	μm	μm	NOUN
eurjchem-596	324	17	,	,	PUNCT
eurjchem-596	324	18	respectively	respectively	ADV
eurjchem-596	324	19	,	,	PUNCT
eurjchem-596	324	20	when	when	SCONJ
eurjchem-596	324	21	the	the	DET
eurjchem-596	324	22	cells	cell	NOUN
eurjchem-596	324	23	were	be	AUX
eurjchem-596	324	24	treated	treat	VERB
eurjchem-596	324	25	with	with	ADP
eurjchem-596	324	26	compounds	compound	NOUN
eurjchem-596	324	27	4d	4d	NUM
eurjchem-596	324	28	,	,	PUNCT
eurjchem-596	324	29	6a	6a	NOUN
eurjchem-596	324	30	,	,	PUNCT
eurjchem-596	324	31	6c	6c	NOUN
eurjchem-596	324	32	,	,	PUNCT
eurjchem-596	324	33	6e	6e	NOUN
eurjchem-596	324	34	,	,	PUNCT
eurjchem-596	324	35	and	and	CCONJ
eurjchem-596	324	36	10	10	NUM
eurjchem-596	324	37	in	in	ADP
eurjchem-596	324	38	combination	combination	NOUN
eurjchem-596	324	39	with	with	ADP
eurjchem-596	324	40	γ‐radiation	γ‐radiation	NOUN
eurjchem-596	324	41	.	.	PUNCT
eurjchem-596	325	1	from	from	ADP
eurjchem-596	325	2	these	these	DET
eurjchem-596	325	3	results	result	NOUN
eurjchem-596	325	4	,	,	PUNCT
eurjchem-596	325	5	we	we	PRON
eurjchem-596	325	6	can	can	AUX
eurjchem-596	325	7	conclude	conclude	VERB
eurjchem-596	325	8	that	that	SCONJ
eurjchem-596	325	9	the	the	DET
eurjchem-596	325	10	combination	combination	NOUN
eurjchem-596	325	11	of	of	ADP
eurjchem-596	325	12	compounds	compound	NOUN
eurjchem-596	325	13	4a	4a	NUM
eurjchem-596	325	14	,	,	PUNCT
eurjchem-596	325	15	4d	4d	NUM
eurjchem-596	325	16	,	,	PUNCT
eurjchem-596	325	17	6a	6a	NOUN
eurjchem-596	325	18	,	,	PUNCT
eurjchem-596	325	19	6c	6c	NOUN
eurjchem-596	325	20	,	,	PUNCT
eurjchem-596	325	21	6e	6e	NUM
eurjchem-596	325	22	and	and	CCONJ
eurjchem-596	325	23	10	10	NUM
eurjchem-596	325	24	and	and	CCONJ
eurjchem-596	325	25	ionizing	ionize	VERB
eurjchem-596	325	26	radiation	radiation	NOUN
eurjchem-596	325	27	synergistically	synergistically	ADV
eurjchem-596	325	28	enhanced	enhance	VERB
eurjchem-596	325	29	growth	growth	NOUN
eurjchem-596	325	30	inhibition	inhibition	NOUN
eurjchem-596	325	31	on	on	ADP
eurjchem-596	325	32	liver	liver	NOUN
eurjchem-596	325	33	cancer	cancer	NOUN
eurjchem-596	325	34	cells	cell	NOUN
eurjchem-596	325	35	,	,	PUNCT
eurjchem-596	325	36	compared	compare	VERB
eurjchem-596	325	37	with	with	ADP
eurjchem-596	325	38	each	each	DET
eurjchem-596	325	39	agent	agent	NOUN
eurjchem-596	325	40	alone	alone	ADV
eurjchem-596	325	41	.	.	PUNCT
eurjchem-596	326	1	4	4	X
eurjchem-596	326	2	.	.	X
eurjchem-596	326	3	conclusion	conclusion	NOUN
eurjchem-596	326	4	we	we	PRON
eurjchem-596	326	5	report	report	VERB
eurjchem-596	326	6	in	in	ADP
eurjchem-596	326	7	this	this	DET
eurjchem-596	326	8	work	work	NOUN
eurjchem-596	326	9	the	the	DET
eurjchem-596	326	10	synthesis	synthesis	NOUN
eurjchem-596	326	11	of	of	ADP
eurjchem-596	326	12	new	new	ADJ
eurjchem-596	326	13	2‐pyridone	2‐pyridone	NUM
eurjchem-596	326	14	,	,	PUNCT
eurjchem-596	326	15	isoquinoline	isoquinoline	ADJ
eurjchem-596	326	16	,	,	PUNCT
eurjchem-596	326	17	chromene	chromene	NOUN
eurjchem-596	326	18	and	and	CCONJ
eurjchem-596	326	19	chromenopyridone	chromenopyridone	NOUN
eurjchem-596	326	20	derivatives	derivative	NOUN
eurjchem-596	326	21	.	.	PUNCT
eurjchem-596	327	1	it	it	PRON
eurjchem-596	327	2	was	be	AUX
eurjchem-596	327	3	clearly	clearly	ADV
eurjchem-596	327	4	observed	observe	VERB
eurjchem-596	327	5	from	from	ADP
eurjchem-596	327	6	the	the	DET
eurjchem-596	327	7	results	result	NOUN
eurjchem-596	327	8	of	of	ADP
eurjchem-596	327	9	in‐vitro	in‐vitro	VERB
eurjchem-596	327	10	cytotoxic	cytotoxic	ADJ
eurjchem-596	327	11	screening	screen	VERB
eurjchem-596	327	12	that	that	SCONJ
eurjchem-596	327	13	some	some	PRON
eurjchem-596	327	14	of	of	ADP
eurjchem-596	327	15	the	the	DET
eurjchem-596	327	16	synthesized	synthesize	VERB
eurjchem-596	327	17	compounds	compound	NOUN
eurjchem-596	327	18	exhibited	exhibit	VERB
eurjchem-596	327	19	significant	significant	ADJ
eurjchem-596	327	20	anticancer	anticancer	NOUN
eurjchem-596	327	21	activity	activity	NOUN
eurjchem-596	327	22	on	on	ADP
eurjchem-596	327	23	ehrlich	ehrlich	NOUN
eurjchem-596	327	24	ascites	ascite	NOUN
eurjchem-596	327	25	carcinoma	carcinoma	NOUN
eurjchem-596	327	26	(	(	PUNCT
eurjchem-596	327	27	eac	eac	PROPN
eurjchem-596	327	28	)	)	PUNCT
eurjchem-596	327	29	and	and	CCONJ
eurjchem-596	327	30	human	human	ADJ
eurjchem-596	327	31	liver	liver	NOUN
eurjchem-596	327	32	tumor	tumor	NOUN
eurjchem-596	327	33	cell	cell	NOUN
eurjchem-596	327	34	line	line	NOUN
eurjchem-596	327	35	(	(	PUNCT
eurjchem-596	327	36	hepg2	hepg2	NOUN
eurjchem-596	327	37	)	)	PUNCT
eurjchem-596	327	38	.	.	PUNCT
eurjchem-596	328	1	while	while	SCONJ
eurjchem-596	328	2	,	,	PUNCT
eurjchem-596	328	3	combining	combine	VERB
eurjchem-596	328	4	these	these	DET
eurjchem-596	328	5	compounds	compound	NOUN
eurjchem-596	328	6	with	with	ADP
eurjchem-596	328	7	radiation	radiation	NOUN
eurjchem-596	328	8	at	at	ADP
eurjchem-596	328	9	the	the	DET
eurjchem-596	328	10	same	same	ADJ
eurjchem-596	328	11	concentrations	concentration	NOUN
eurjchem-596	328	12	enhances	enhance	VERB
eurjchem-596	328	13	their	their	PRON
eurjchem-596	328	14	activity	activity	NOUN
eurjchem-596	328	15	which	which	PRON
eurjchem-596	328	16	demonstrates	demonstrate	VERB
eurjchem-596	328	17	the	the	DET
eurjchem-596	328	18	importance	importance	NOUN
eurjchem-596	328	19	of	of	ADP
eurjchem-596	328	20	the	the	DET
eurjchem-596	328	21	combination	combination	NOUN
eurjchem-596	328	22	therapy	therapy	NOUN
eurjchem-596	328	23	for	for	ADP
eurjchem-596	328	24	the	the	DET
eurjchem-596	328	25	patients	patient	NOUN
eurjchem-596	328	26	with	with	ADP
eurjchem-596	328	27	cancer	cancer	NOUN
eurjchem-596	328	28	to	to	PART
eurjchem-596	328	29	decrease	decrease	VERB
eurjchem-596	328	30	the	the	DET
eurjchem-596	328	31	side	side	NOUN
eurjchem-596	328	32	effects	effect	NOUN
eurjchem-596	328	33	of	of	ADP
eurjchem-596	328	34	both	both	DET
eurjchem-596	328	35	drugs	drug	NOUN
eurjchem-596	328	36	and	and	CCONJ
eurjchem-596	328	37	radiation	radiation	NOUN
eurjchem-596	328	38	.	.	PUNCT
eurjchem-596	329	1	acknowledgements	acknowledgement	NOUN
eurjchem-596	329	2	the	the	DET
eurjchem-596	329	3	authors	author	NOUN
eurjchem-596	329	4	are	be	AUX
eurjchem-596	329	5	grateful	grateful	ADJ
eurjchem-596	329	6	to	to	ADP
eurjchem-596	329	7	the	the	DET
eurjchem-596	329	8	sponsorship	sponsorship	NOUN
eurjchem-596	329	9	of	of	ADP
eurjchem-596	329	10	the	the	DET
eurjchem-596	329	11	research	research	NOUN
eurjchem-596	329	12	center	center	NOUN
eurjchem-596	329	13	,	,	PUNCT
eurjchem-596	329	14	college	college	NOUN
eurjchem-596	329	15	of	of	ADP
eurjchem-596	329	16	pharmacy	pharmacy	NOUN
eurjchem-596	329	17	and	and	CCONJ
eurjchem-596	329	18	the	the	DET
eurjchem-596	329	19	deanship	deanship	NOUN
eurjchem-596	329	20	of	of	ADP
eurjchem-596	329	21	scientific	scientific	ADJ
eurjchem-596	329	22	research	research	NOUN
eurjchem-596	329	23	,	,	PUNCT
eurjchem-596	329	24	king	king	PROPN
eurjchem-596	329	25	saud	saud	PROPN
eurjchem-596	329	26	university	university	PROPN
eurjchem-596	329	27	,	,	PUNCT
eurjchem-596	329	28	riyadh	riyadh	PROPN
eurjchem-596	329	29	,	,	PUNCT
eurjchem-596	329	30	saudi	saudi	PROPN
eurjchem-596	329	31	arabia	arabia	PROPN
eurjchem-596	329	32	.	.	PUNCT
eurjchem-596	330	1	references	reference	NOUN
eurjchem-596	330	2	[	[	X
eurjchem-596	330	3	1	1	NUM
eurjchem-596	330	4	]	]	PUNCT
eurjchem-596	330	5	.	.	PUNCT
eurjchem-596	331	1	abadi	abadi	PROPN
eurjchem-596	331	2	,	,	PUNCT
eurjchem-596	331	3	a.	a.	PROPN
eurjchem-596	331	4	h.	h.	PROPN
eurjchem-596	331	5	;	;	PUNCT
eurjchem-596	331	6	ibrahim	ibrahim	PROPN
eurjchem-596	331	7	,	,	PUNCT
eurjchem-596	331	8	t.	t.	NOUN
eurjchem-596	331	9	m.	m.	NOUN
eurjchem-596	331	10	;	;	PUNCT
eurjchem-596	331	11	abouzid	abouzid	PROPN
eurjchem-596	331	12	,	,	PUNCT
eurjchem-596	331	13	k.	k.	PROPN
eurjchem-596	331	14	m.	m.	PROPN
eurjchem-596	331	15	;	;	PUNCT
eurjchem-596	331	16	lehmann	lehmann	PROPN
eurjchem-596	331	17	.	.	PUNCT
eurjchem-596	332	1	j.	j.	PROPN
eurjchem-596	332	2	;	;	PUNCT
eurjchem-596	332	3	tinsley	tinsley	PROPN
eurjchem-596	332	4	,	,	PUNCT
eurjchem-596	332	5	h.	h.	PROPN
eurjchem-596	332	6	n.	n.	PROPN
eurjchem-596	332	7	;	;	PUNCT
eurjchem-596	332	8	gary	gary	PROPN
eurjchem-596	332	9	,	,	PUNCT
eurjchem-596	332	10	b.	b.	PROPN
eurjchem-596	332	11	d.	d.	PROPN
eurjchem-596	332	12	;	;	PUNCT
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eurjchem-596	332	14	,	,	PUNCT
eurjchem-596	332	15	g.	g.	PROPN
eurjchem-596	332	16	a.	a.	NOUN
eurjchem-596	332	17	bioorg	bioorg	PROPN
eurjchem-596	332	18	.	.	PUNCT
eurjchem-596	333	1	med	med	PROPN
eurjchem-596	333	2	.	.	PUNCT
eurjchem-596	333	3	chem	chem	PROPN
eurjchem-596	333	4	.	.	PUNCT
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eurjchem-596	334	2	,	,	PUNCT
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eurjchem-596	334	4	,	,	PUNCT
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eurjchem-596	334	6	.	.	PUNCT
eurjchem-596	335	1	[	[	X
eurjchem-596	335	2	2	2	NUM
eurjchem-596	335	3	]	]	PUNCT
eurjchem-596	335	4	.	.	PUNCT
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eurjchem-596	336	3	i.	i.	PROPN
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eurjchem-596	336	9	;	;	PUNCT
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eurjchem-596	336	13	;	;	PUNCT
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eurjchem-596	336	25	;	;	PUNCT
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eurjchem-596	336	27	,	,	PUNCT
eurjchem-596	336	28	r.	r.	PROPN
eurjchem-596	336	29	;	;	PUNCT
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eurjchem-596	336	31	,	,	PUNCT
eurjchem-596	336	32	z.	z.	PROPN
eurjchem-596	336	33	;	;	PUNCT
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eurjchem-596	336	35	,	,	PUNCT
eurjchem-596	336	36	j.	j.	PROPN
eurjchem-596	336	37	z.	z.	PROPN
eurjchem-596	336	38	bioorg	bioorg	PROPN
eurjchem-596	336	39	.	.	PUNCT
eurjchem-596	337	1	med	med	PROPN
eurjchem-596	337	2	.	.	PROPN
eurjchem-596	337	3	chem	chem	PROPN
eurjchem-596	337	4	.	.	PUNCT
eurjchem-596	338	1	lett	lett	PROPN
eurjchem-596	338	2	.	.	PUNCT
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eurjchem-596	339	2	,	,	PUNCT
eurjchem-596	339	3	17	17	NUM
eurjchem-596	339	4	,	,	PUNCT
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eurjchem-596	339	6	.	.	PUNCT
eurjchem-596	340	1	[	[	X
eurjchem-596	340	2	3	3	NUM
eurjchem-596	340	3	]	]	PUNCT
eurjchem-596	340	4	.	.	PUNCT
eurjchem-596	341	1	wendt	wendt	PROPN
eurjchem-596	341	2	,	,	PUNCT
eurjchem-596	341	3	m.	m.	PROPN
eurjchem-596	341	4	d.	d.	PROPN
eurjchem-596	341	5	;	;	PUNCT
eurjchem-596	341	6	sun	sun	PROPN
eurjchem-596	341	7	,	,	PUNCT
eurjchem-596	341	8	c.	c.	PROPN
eurjchem-596	341	9	;	;	PUNCT
eurjchem-596	341	10	kunzer	kunzer	PROPN
eurjchem-596	341	11	,	,	PUNCT
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eurjchem-596	341	13	;	;	PUNCT
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eurjchem-596	341	17	;	;	PUNCT
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eurjchem-596	341	20	k.	k.	PROPN
eurjchem-596	341	21	;	;	PUNCT
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eurjchem-596	341	24	e.	e.	PROPN
eurjchem-596	341	25	;	;	PUNCT
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eurjchem-596	341	29	;	;	PUNCT
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eurjchem-596	341	37	j.	j.	PROPN
eurjchem-596	341	38	;	;	PUNCT
eurjchem-596	341	39	jin	jin	PROPN
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eurjchem-596	341	41	s.	s.	PROPN
eurjchem-596	341	42	;	;	PUNCT
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eurjchem-596	343	2	.	.	PUNCT
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eurjchem-596	344	6	.	.	PUNCT
eurjchem-596	345	1	[	[	X
eurjchem-596	345	2	4	4	NUM
eurjchem-596	345	3	]	]	PUNCT
eurjchem-596	345	4	.	.	PUNCT
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eurjchem-596	348	6	.	.	PUNCT
eurjchem-596	349	1	[	[	X
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eurjchem-596	349	3	]	]	PUNCT
eurjchem-596	349	4	.	.	PUNCT
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eurjchem-596	349	8	;	;	PUNCT
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eurjchem-596	349	12	;	;	PUNCT
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eurjchem-596	350	1	med	med	PROPN
eurjchem-596	350	2	.	.	PUNCT
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eurjchem-596	351	2	,	,	PUNCT
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eurjchem-596	351	4	,	,	PUNCT
eurjchem-596	351	5	917‐921	917‐921	NUM
eurjchem-596	351	6	.	.	PUNCT
eurjchem-596	352	1	[	[	X
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eurjchem-596	352	3	]	]	PUNCT
eurjchem-596	352	4	.	.	PUNCT
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eurjchem-596	353	4	;	;	PUNCT
eurjchem-596	353	5	soh	soh	PROPN
eurjchem-596	353	6	,	,	PUNCT
eurjchem-596	353	7	j.	j.	PROPN
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eurjchem-596	353	9	;	;	PUNCT
eurjchem-596	353	10	mao	mao	PROPN
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eurjchem-596	353	13	;	;	PUNCT
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eurjchem-596	355	3	]	]	PUNCT
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eurjchem-596	358	1	[	[	X
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eurjchem-596	358	3	]	]	PUNCT
eurjchem-596	358	4	.	.	PUNCT
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eurjchem-596	362	1	[	[	X
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eurjchem-596	362	3	]	]	PUNCT
eurjchem-596	362	4	.	.	PUNCT
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eurjchem-596	363	25	;	;	PUNCT
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eurjchem-596	363	30	.	.	PUNCT
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eurjchem-596	364	4	.	.	PUNCT
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eurjchem-596	365	2	,	,	PUNCT
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eurjchem-596	365	4	,	,	PUNCT
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eurjchem-596	365	6	.	.	PUNCT
eurjchem-596	366	1	[	[	X
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eurjchem-596	366	3	]	]	PUNCT
eurjchem-596	366	4	.	.	PUNCT
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eurjchem-596	367	20	;	;	PUNCT
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eurjchem-596	367	25	;	;	PUNCT
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eurjchem-596	368	1	j.	j.	PROPN
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eurjchem-596	368	5	.	.	PUNCT
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eurjchem-596	369	2	,	,	PUNCT
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eurjchem-596	370	3	]	]	PUNCT
eurjchem-596	370	4	.	.	PUNCT
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eurjchem-596	371	5	;	;	PUNCT
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eurjchem-596	372	5	.	.	PUNCT
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eurjchem-596	373	2	,	,	PUNCT
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eurjchem-596	373	6	.	.	PUNCT
eurjchem-596	374	1	[	[	X
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eurjchem-596	374	3	]	]	PUNCT
eurjchem-596	374	4	.	.	PUNCT
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eurjchem-596	375	20	;	;	PUNCT
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eurjchem-596	376	5	.	.	PUNCT
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eurjchem-596	377	6	.	.	PUNCT
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eurjchem-596	378	3	]	]	PUNCT
eurjchem-596	378	4	.	.	PUNCT
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eurjchem-596	379	5	;	;	PUNCT
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eurjchem-596	379	23	e.	e.	PROPN
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eurjchem-596	379	25	.	.	PUNCT
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eurjchem-596	380	4	.	.	PUNCT
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eurjchem-596	381	2	.	.	PUNCT
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eurjchem-596	382	2	,	,	PUNCT
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eurjchem-596	382	4	,	,	PUNCT
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eurjchem-596	382	6	.	.	PUNCT
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eurjchem-596	383	4	.	.	PUNCT
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eurjchem-596	386	4	.	.	PUNCT
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eurjchem-596	387	5	;	;	PUNCT
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eurjchem-596	388	1	j.	j.	PROPN
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eurjchem-596	388	5	.	.	PUNCT
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eurjchem-596	389	4	,	,	PUNCT
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eurjchem-596	389	6	.	.	PUNCT
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eurjchem-596	390	4	.	.	PUNCT
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eurjchem-596	391	5	;	;	PUNCT
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eurjchem-596	391	10	;	;	PUNCT
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eurjchem-596	391	25	.	.	PUNCT
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eurjchem-596	392	5	.	.	PUNCT
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eurjchem-596	393	2	,	,	PUNCT
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eurjchem-596	393	4	,	,	PUNCT
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eurjchem-596	393	6	.	.	PUNCT
eurjchem-596	394	1	[	[	X
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eurjchem-596	394	4	.	.	PUNCT
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eurjchem-596	395	5	;	;	PUNCT
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eurjchem-596	395	8	f.	f.	PROPN
eurjchem-596	395	9	e.	e.	PROPN
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eurjchem-596	395	14	c.	c.	PROPN
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eurjchem-596	397	3	37(3	37(3	NUM
eurjchem-596	397	4	)	)	PUNCT
eurjchem-596	397	5	,	,	PUNCT
eurjchem-596	397	6	231‐	231‐	NUM
eurjchem-596	397	7	236	236	NUM
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eurjchem-596	398	1	[	[	X
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eurjchem-596	399	4	;	;	PUNCT
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eurjchem-596	401	6	.	.	PUNCT
eurjchem-596	402	1	[	[	X
eurjchem-596	402	2	19	19	NUM
eurjchem-596	402	3	]	]	PUNCT
eurjchem-596	402	4	.	.	PUNCT
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eurjchem-596	403	2	,	,	PUNCT
eurjchem-596	403	3	y.	y.	PROPN
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eurjchem-596	403	5	.	.	PUNCT
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eurjchem-596	405	2	.	.	PUNCT
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eurjchem-596	406	2	,	,	PUNCT
eurjchem-596	406	3	9	9	NUM
eurjchem-596	406	4	,	,	PUNCT
eurjchem-596	406	5	414‐420	414‐420	NUM
eurjchem-596	406	6	.	.	PUNCT