id	sid	tid	token	lemma	pos
eurjchem-701	1	1	untitled	untitle	VERB
eurjchem-701	1	2	european	european	PROPN
eurjchem-701	1	3	journal	journal	PROPN
eurjchem-701	1	4	of	of	ADP
eurjchem-701	1	5	chemistry	chemistry	NOUN
eurjchem-701	1	6	4	4	NUM
eurjchem-701	1	7	(	(	PUNCT
eurjchem-701	1	8	1	1	NUM
eurjchem-701	1	9	)	)	PUNCT
eurjchem-701	1	10	(	(	PUNCT
eurjchem-701	1	11	2013	2013	NUM
eurjchem-701	1	12	)	)	PUNCT
eurjchem-701	1	13	49‐52	49‐52	NUM
eurjchem-701	1	14	european	european	ADJ
eurjchem-701	1	15	journal	journal	PROPN
eurjchem-701	1	16	of	of	ADP
eurjchem-701	1	17	chemistry	chemistry	NOUN
eurjchem-701	1	18	issn	issn	PROPN
eurjchem-701	1	19	2153‐2249	2153‐2249	PROPN
eurjchem-701	1	20	(	(	PUNCT
eurjchem-701	1	21	print	print	NOUN
eurjchem-701	1	22	)	)	PUNCT
eurjchem-701	1	23	/	/	SYM
eurjchem-701	1	24	issn	issn	PROPN
eurjchem-701	1	25	2153‐2257	2153‐2257	NUM
eurjchem-701	1	26	(	(	PUNCT
eurjchem-701	1	27	online	online	ADJ
eurjchem-701	1	28	)	)	PUNCT
eurjchem-701	1	29			NOUN
eurjchem-701	1	30	2013	2013	NUM
eurjchem-701	1	31	eurjchem	eurjchem	PROPN
eurjchem-701	1	32	doi:10.5155	doi:10.5155	PROPN
eurjchem-701	1	33	/	/	SYM
eurjchem-701	1	34	eurjchem.4.1.49‐52.701	eurjchem.4.1.49‐52.701	NOUN
eurjchem-701	1	35	european	european	ADJ
eurjchem-701	1	36	journal	journal	PROPN
eurjchem-701	1	37	of	of	ADP
eurjchem-701	1	38	chemistry	chemistry	PROPN
eurjchem-701	1	39	journal	journal	PROPN
eurjchem-701	1	40	homepage	homepage	NOUN
eurjchem-701	1	41	:	:	PUNCT
eurjchem-701	1	42	www.eurjchem.com	www.eurjchem.com	X
eurjchem-701	2	1	urease	urease	VERB
eurjchem-701	2	2	inhibition	inhibition	NOUN
eurjchem-701	2	3	and	and	CCONJ
eurjchem-701	2	4	anticancer	anticancer	NOUN
eurjchem-701	2	5	activity	activity	NOUN
eurjchem-701	2	6	of	of	ADP
eurjchem-701	2	7	novel	novel	ADJ
eurjchem-701	2	8	polyfunctional	polyfunctional	ADJ
eurjchem-701	2	9	5,6‐dihydropyridine	5,6‐dihydropyridine	NUM
eurjchem-701	2	10	derivatives	derivative	NOUN
eurjchem-701	2	11	and	and	CCONJ
eurjchem-701	2	12	their	their	PRON
eurjchem-701	2	13	structure‐activity	structure‐activity	NOUN
eurjchem-701	2	14	relationship	relationship	NOUN
eurjchem-701	2	15	abdul	abdul	PROPN
eurjchem-701	2	16	hameed	hameed	PROPN
eurjchem-701	2	17	a	a	PROPN
eurjchem-701	2	18	,	,	PUNCT
eurjchem-701	2	19	*	*	PROPN
eurjchem-701	2	20	,	,	PUNCT
eurjchem-701	2	21	ayaz	ayaz	PROPN
eurjchem-701	2	22	anwar	anwar	PROPN
eurjchem-701	2	23	a	a	PRON
eurjchem-701	2	24	,	,	PUNCT
eurjchem-701	2	25	khalid	khalid	PROPN
eurjchem-701	2	26	mohammed	mohammed	PROPN
eurjchem-701	2	27	khan	khan	PROPN
eurjchem-701	2	28	b	b	PROPN
eurjchem-701	2	29	,	,	PUNCT
eurjchem-701	2	30	rizwana	rizwana	PROPN
eurjchem-701	2	31	malik	malik	PROPN
eurjchem-701	2	32	b	b	PROPN
eurjchem-701	2	33	,	,	PUNCT
eurjchem-701	2	34	fernaz	fernaz	PROPN
eurjchem-701	2	35	shahab	shahab	PROPN
eurjchem-701	2	36	b	b	PROPN
eurjchem-701	2	37	,	,	PUNCT
eurjchem-701	2	38	sadia	sadia	PROPN
eurjchem-701	2	39	siddiq	siddiq	PROPN
eurjchem-701	2	40	b	b	PROPN
eurjchem-701	2	41	,	,	PUNCT
eurjchem-701	2	42	fatima	fatima	PROPN
eurjchem-701	2	43	zahra	zahra	PROPN
eurjchem-701	2	44	basha	basha	PROPN
eurjchem-701	2	45	a	a	PROPN
eurjchem-701	2	46	and	and	CCONJ
eurjchem-701	2	47	muhammad	muhammad	PROPN
eurjchem-701	2	48	iqbal	iqbal	PROPN
eurjchem-701	2	49	choudhary	choudhary	PROPN
eurjchem-701	3	1	a	a	PROPN
eurjchem-701	3	2	,	,	PUNCT
eurjchem-701	3	3	b	b	PROPN
eurjchem-701	3	4	a	a	DET
eurjchem-701	3	5	third	third	ADJ
eurjchem-701	3	6	world	world	NOUN
eurjchem-701	3	7	labortary	labortary	ADJ
eurjchem-701	3	8	building	building	NOUN
eurjchem-701	3	9	,	,	PUNCT
eurjchem-701	3	10	international	international	ADJ
eurjchem-701	3	11	center	center	NOUN
eurjchem-701	3	12	for	for	ADP
eurjchem-701	3	13	chemical	chemical	NOUN
eurjchem-701	3	14	and	and	CCONJ
eurjchem-701	3	15	biological	biological	ADJ
eurjchem-701	3	16	sciences	science	NOUN
eurjchem-701	3	17	,	,	PUNCT
eurjchem-701	3	18	university	university	NOUN
eurjchem-701	3	19	karachi	karachi	PROPN
eurjchem-701	3	20	,	,	PUNCT
eurjchem-701	3	21	karachi‐75270	karachi‐75270	PROPN
eurjchem-701	3	22	,	,	PUNCT
eurjchem-701	3	23	pakistan	pakistan	PROPN
eurjchem-701	3	24	b	b	PROPN
eurjchem-701	3	25	husein	husein	PROPN
eurjchem-701	3	26	ebrahim	ebrahim	PROPN
eurjchem-701	3	27	jamal	jamal	PROPN
eurjchem-701	3	28	research	research	PROPN
eurjchem-701	3	29	institute	institute	PROPN
eurjchem-701	3	30	of	of	ADP
eurjchem-701	3	31	chemistry	chemistry	PROPN
eurjchem-701	3	32	,	,	PUNCT
eurjchem-701	3	33	international	international	ADJ
eurjchem-701	3	34	center	center	NOUN
eurjchem-701	3	35	for	for	ADP
eurjchem-701	3	36	chemical	chemical	NOUN
eurjchem-701	3	37	and	and	CCONJ
eurjchem-701	3	38	biological	biological	ADJ
eurjchem-701	3	39	sciences	science	NOUN
eurjchem-701	3	40	,	,	PUNCT
eurjchem-701	3	41	university	university	PROPN
eurjchem-701	3	42	of	of	ADP
eurjchem-701	3	43	karachi	karachi	PROPN
eurjchem-701	3	44	,	,	PUNCT
eurjchem-701	3	45	karachi‐75270	karachi‐75270	PROPN
eurjchem-701	3	46	,	,	PUNCT
eurjchem-701	3	47	pakistan	pakistan	PROPN
eurjchem-701	3	48	*	*	PUNCT
eurjchem-701	3	49	corresponding	correspond	VERB
eurjchem-701	3	50	author	author	NOUN
eurjchem-701	3	51	at	at	ADP
eurjchem-701	3	52	:	:	PUNCT
eurjchem-701	3	53	third	third	ADJ
eurjchem-701	3	54	world	world	NOUN
eurjchem-701	3	55	labortary	labortary	ADJ
eurjchem-701	3	56	building	building	NOUN
eurjchem-701	3	57	,	,	PUNCT
eurjchem-701	3	58	international	international	ADJ
eurjchem-701	3	59	center	center	NOUN
eurjchem-701	3	60	for	for	ADP
eurjchem-701	3	61	chemical	chemical	NOUN
eurjchem-701	3	62	and	and	CCONJ
eurjchem-701	3	63	biological	biological	ADJ
eurjchem-701	3	64	sciences	science	NOUN
eurjchem-701	3	65	,	,	PUNCT
eurjchem-701	3	66	university	university	NOUN
eurjchem-701	3	67	karachi	karachi	PROPN
eurjchem-701	3	68	,	,	PUNCT
eurjchem-701	3	69	karachi‐75270	karachi‐75270	PROPN
eurjchem-701	3	70	,	,	PUNCT
eurjchem-701	3	71	pakistan	pakistan	PROPN
eurjchem-701	3	72	.	.	PUNCT
eurjchem-701	4	1	tel	tel	PROPN
eurjchem-701	4	2	.	.	PUNCT
eurjchem-701	4	3	:	:	PUNCT
eurjchem-701	5	1	+92.219.9261701‐2	+92.219.9261701‐2	VERB
eurjchem-701	5	2	/	/	SYM
eurjchem-701	5	3	ext.240	ext.240	NOUN
eurjchem-701	5	4	;	;	PUNCT
eurjchem-701	5	5	fax	fax	NOUN
eurjchem-701	5	6	:	:	PUNCT
eurjchem-701	5	7	+92.213.4819018	+92.213.4819018	NUM
eurjchem-701	5	8	.	.	PUNCT
eurjchem-701	5	9	e‐mail	e‐mail	PUNCT
eurjchem-701	6	1	address	address	NOUN
eurjchem-701	6	2	:	:	PUNCT
eurjchem-701	6	3	abdul.hameed@iccs.edu	abdul.hameed@iccs.edu	PROPN
eurjchem-701	6	4	(	(	PUNCT
eurjchem-701	6	5	a.	a.	NOUN
eurjchem-701	6	6	hameed	hameed	PROPN
eurjchem-701	6	7	)	)	PUNCT
eurjchem-701	6	8	article	article	NOUN
eurjchem-701	6	9	information	information	NOUN
eurjchem-701	6	10	abstract	abstract	ADV
eurjchem-701	6	11	received	receive	VERB
eurjchem-701	6	12	:	:	PUNCT
eurjchem-701	6	13	07	07	NUM
eurjchem-701	6	14	november	november	PROPN
eurjchem-701	6	15	2012	2012	NUM
eurjchem-701	6	16	accepted	accept	VERB
eurjchem-701	6	17	:	:	PUNCT
eurjchem-701	6	18	27	27	NUM
eurjchem-701	6	19	november	november	PROPN
eurjchem-701	6	20	2012	2012	NUM
eurjchem-701	6	21	online	online	NOUN
eurjchem-701	6	22	:	:	PUNCT
eurjchem-701	6	23	31	31	NUM
eurjchem-701	6	24	march	march	NOUN
eurjchem-701	6	25	2013	2013	NUM
eurjchem-701	6	26	keywords	keyword	VERB
eurjchem-701	6	27	a	a	DET
eurjchem-701	6	28	novel	novel	ADJ
eurjchem-701	6	29	series	series	NOUN
eurjchem-701	6	30	of	of	ADP
eurjchem-701	6	31	tricyano	tricyano	PROPN
eurjchem-701	6	32	substituted	substitute	VERB
eurjchem-701	6	33	polyfunctional	polyfunctional	ADJ
eurjchem-701	6	34	5,6‐dihydropyridine	5,6‐dihydropyridine	NUM
eurjchem-701	6	35	8a‐n	8a‐n	NOUN
eurjchem-701	6	36	bearing	bear	VERB
eurjchem-701	6	37	functionalized	functionalize	VERB
eurjchem-701	6	38	aromatic	aromatic	ADJ
eurjchem-701	6	39	rings	ring	NOUN
eurjchem-701	6	40	at	at	ADP
eurjchem-701	6	41	c‐4	c‐4	PROPN
eurjchem-701	6	42	and	and	CCONJ
eurjchem-701	6	43	c‐6	c‐6	NOUN
eurjchem-701	6	44	position	position	NOUN
eurjchem-701	6	45	have	have	AUX
eurjchem-701	6	46	been	be	AUX
eurjchem-701	6	47	prepared	prepare	VERB
eurjchem-701	6	48	from	from	ADP
eurjchem-701	6	49	(	(	PUNCT
eurjchem-701	6	50	α‐	α‐	NUM
eurjchem-701	6	51	methylbenzylidene	methylbenzylidene	NOUN
eurjchem-701	6	52	)	)	PUNCT
eurjchem-701	6	53	malononitriles	malononitrile	NOUN
eurjchem-701	6	54	in	in	ADP
eurjchem-701	6	55	good	good	ADJ
eurjchem-701	6	56	to	to	ADP
eurjchem-701	6	57	excellent	excellent	ADJ
eurjchem-701	6	58	yields	yield	NOUN
eurjchem-701	6	59	(	(	PUNCT
eurjchem-701	6	60	52‐98	52‐98	NUM
eurjchem-701	6	61	%	%	NOUN
eurjchem-701	6	62	)	)	PUNCT
eurjchem-701	6	63	in	in	ADP
eurjchem-701	6	64	solvent	solvent	ADJ
eurjchem-701	6	65	free	free	ADJ
eurjchem-701	6	66	conditions	condition	NOUN
eurjchem-701	6	67	.	.	PUNCT
eurjchem-701	7	1	all	all	DET
eurjchem-701	7	2	the	the	DET
eurjchem-701	7	3	synthesized	synthesize	VERB
eurjchem-701	7	4	compounds	compound	NOUN
eurjchem-701	7	5	(	(	PUNCT
eurjchem-701	7	6	8a‐n	8a‐n	VERB
eurjchem-701	7	7	)	)	PUNCT
eurjchem-701	7	8	were	be	AUX
eurjchem-701	7	9	evaluated	evaluate	VERB
eurjchem-701	7	10	for	for	ADP
eurjchem-701	7	11	their	their	PRON
eurjchem-701	7	12	in	in	X
eurjchem-701	7	13	vitro	vitro	X
eurjchem-701	7	14	urease	urease	NOUN
eurjchem-701	7	15	inhibition	inhibition	NOUN
eurjchem-701	7	16	and	and	CCONJ
eurjchem-701	7	17	anticancer	anticancer	NOUN
eurjchem-701	7	18	activity	activity	NOUN
eurjchem-701	7	19	against	against	ADP
eurjchem-701	7	20	prostate	prostate	NOUN
eurjchem-701	7	21	cancer	cancer	NOUN
eurjchem-701	7	22	(	(	PUNCT
eurjchem-701	7	23	pc3	pc3	PROPN
eurjchem-701	7	24	)	)	PUNCT
eurjchem-701	7	25	and	and	CCONJ
eurjchem-701	7	26	hela	hela	PROPN
eurjchem-701	7	27	cell	cell	NOUN
eurjchem-701	7	28	lines	line	NOUN
eurjchem-701	7	29	.	.	PUNCT
eurjchem-701	8	1	compound	compound	NOUN
eurjchem-701	8	2	8k	8k	PROPN
eurjchem-701	8	3	(	(	PUNCT
eurjchem-701	8	4	4,6‐bis(4‐methoxyphenyl)‐5,6‐dihydropyridin	4,6‐bis(4‐methoxyphenyl)‐5,6‐dihydropyridin	NOUN
eurjchem-701	8	5	)	)	PUNCT
eurjchem-701	8	6	showed	show	VERB
eurjchem-701	8	7	slightly	slightly	ADV
eurjchem-701	8	8	better	well	ADJ
eurjchem-701	8	9	urease	urease	VERB
eurjchem-701	8	10	inhibitory	inhibitory	ADJ
eurjchem-701	8	11	potential	potential	NOUN
eurjchem-701	8	12	(	(	PUNCT
eurjchem-701	8	13	ic50	ic50	PROPN
eurjchem-701	8	14	=	=	PROPN
eurjchem-701	8	15	20.47	20.47	NUM
eurjchem-701	8	16	µm	µm	NOUN
eurjchem-701	8	17	)	)	PUNCT
eurjchem-701	8	18	as	as	ADP
eurjchem-701	8	19	compared	compare	VERB
eurjchem-701	8	20	to	to	ADP
eurjchem-701	8	21	standard	standard	ADJ
eurjchem-701	8	22	thiourea	thiourea	NOUN
eurjchem-701	8	23	(	(	PUNCT
eurjchem-701	8	24	ic50	ic50	PROPN
eurjchem-701	8	25	=	=	PROPN
eurjchem-701	8	26	21	21	NUM
eurjchem-701	8	27	µm	µm	NOUN
eurjchem-701	8	28	)	)	PUNCT
eurjchem-701	8	29	.	.	PUNCT
eurjchem-701	9	1	whilst	whilst	SCONJ
eurjchem-701	9	2	in	in	ADP
eurjchem-701	9	3	the	the	DET
eurjchem-701	9	4	case	case	NOUN
eurjchem-701	9	5	of	of	ADP
eurjchem-701	9	6	anticancer	anticancer	NOUN
eurjchem-701	9	7	studies	study	NOUN
eurjchem-701	9	8	the	the	DET
eurjchem-701	9	9	compound	compound	NOUN
eurjchem-701	9	10	8a	8a	PROPN
eurjchem-701	10	1	2‐(4,6‐bis(4‐bromophenyl)‐6‐methyl‐5,6‐	2‐(4,6‐bis(4‐bromophenyl)‐6‐methyl‐5,6‐	PROPN
eurjchem-701	10	2	dihydropyridin	dihydropyridin	VERB
eurjchem-701	10	3	found	find	VERB
eurjchem-701	10	4	to	to	PART
eurjchem-701	10	5	be	be	AUX
eurjchem-701	10	6	most	most	ADV
eurjchem-701	10	7	active	active	ADJ
eurjchem-701	10	8	(	(	PUNCT
eurjchem-701	10	9	ic50	ic50	PROPN
eurjchem-701	10	10	=	=	PROPN
eurjchem-701	10	11	4.40	4.40	NUM
eurjchem-701	10	12	and	and	CCONJ
eurjchem-701	10	13	8.80	8.80	NUM
eurjchem-701	10	14	µm	µm	NOUN
eurjchem-701	10	15	)	)	PUNCT
eurjchem-701	10	16	among	among	ADP
eurjchem-701	10	17	the	the	DET
eurjchem-701	10	18	series	series	NOUN
eurjchem-701	10	19	when	when	SCONJ
eurjchem-701	10	20	compared	compare	VERB
eurjchem-701	10	21	with	with	ADP
eurjchem-701	10	22	standard	standard	ADJ
eurjchem-701	10	23	doxorubicin	doxorubicin	PROPN
eurjchem-701	10	24	4	4	NUM
eurjchem-701	10	25	(	(	PUNCT
eurjchem-701	10	26	ic50	ic50	PROPN
eurjchem-701	10	27	=	=	PROPN
eurjchem-701	10	28	0.91	0.91	NUM
eurjchem-701	10	29	and	and	CCONJ
eurjchem-701	10	30	3.1	3.1	NUM
eurjchem-701	10	31	µm	µm	NOUN
eurjchem-701	10	32	)	)	PUNCT
eurjchem-701	10	33	in	in	ADP
eurjchem-701	10	34	both	both	DET
eurjchem-701	10	35	cell	cell	NOUN
eurjchem-701	10	36	lines	line	NOUN
eurjchem-701	10	37	respectively	respectively	ADV
eurjchem-701	10	38	.	.	PUNCT
eurjchem-701	11	1	a	a	DET
eurjchem-701	11	2	structure‐activity	structure‐activity	NOUN
eurjchem-701	11	3	relationship	relationship	NOUN
eurjchem-701	11	4	of	of	ADP
eurjchem-701	11	5	this	this	DET
eurjchem-701	11	6	series	series	NOUN
eurjchem-701	11	7	has	have	AUX
eurjchem-701	11	8	been	be	AUX
eurjchem-701	11	9	established	establish	VERB
eurjchem-701	11	10	on	on	ADP
eurjchem-701	11	11	the	the	DET
eurjchem-701	11	12	basis	basis	NOUN
eurjchem-701	11	13	of	of	ADP
eurjchem-701	11	14	electronic	electronic	ADJ
eurjchem-701	11	15	effects	effect	NOUN
eurjchem-701	11	16	and	and	CCONJ
eurjchem-701	11	17	position	position	NOUN
eurjchem-701	11	18	of	of	ADP
eurjchem-701	11	19	different	different	ADJ
eurjchem-701	11	20	substituents	substituent	NOUN
eurjchem-701	11	21	(	(	PUNCT
eurjchem-701	11	22	h	h	NOUN
eurjchem-701	11	23	,	,	PUNCT
eurjchem-701	11	24	br	br	PROPN
eurjchem-701	11	25	,	,	PUNCT
eurjchem-701	11	26	cl	cl	NOUN
eurjchem-701	11	27	,	,	PUNCT
eurjchem-701	11	28	i	i	PRON
eurjchem-701	11	29	,	,	PUNCT
eurjchem-701	11	30	f	f	PROPN
eurjchem-701	11	31	,	,	PUNCT
eurjchem-701	11	32	me	i	PRON
eurjchem-701	11	33	,	,	PUNCT
eurjchem-701	11	34	ome	ome	PROPN
eurjchem-701	11	35	,	,	PUNCT
eurjchem-701	11	36	oh	oh	INTJ
eurjchem-701	11	37	,	,	PUNCT
eurjchem-701	11	38	and	and	CCONJ
eurjchem-701	11	39	no2	no2	NOUN
eurjchem-701	11	40	)	)	PUNCT
eurjchem-701	11	41	present	present	ADJ
eurjchem-701	11	42	on	on	ADP
eurjchem-701	11	43	the	the	DET
eurjchem-701	11	44	c‐4	c‐4	PROPN
eurjchem-701	11	45	and	and	CCONJ
eurjchem-701	11	46	c‐6	c‐6	PROPN
eurjchem-701	11	47	phenyl	phenyl	NOUN
eurjchem-701	11	48	rings	ring	NOUN
eurjchem-701	11	49	.	.	PUNCT
eurjchem-701	12	1	the	the	DET
eurjchem-701	12	2	anticancer	anticancer	NOUN
eurjchem-701	12	3	activity	activity	NOUN
eurjchem-701	12	4	evaluation	evaluation	NOUN
eurjchem-701	12	5	of	of	ADP
eurjchem-701	12	6	these	these	DET
eurjchem-701	12	7	pyridine	pyridine	NOUN
eurjchem-701	12	8	derivatives	derivative	NOUN
eurjchem-701	12	9	envisage	envisage	VERB
eurjchem-701	12	10	that	that	SCONJ
eurjchem-701	12	11	the	the	DET
eurjchem-701	12	12	compound	compound	NOUN
eurjchem-701	12	13	8a	8a	NUM
eurjchem-701	12	14	could	could	AUX
eurjchem-701	12	15	be	be	AUX
eurjchem-701	12	16	putatively	putatively	ADV
eurjchem-701	12	17	linked	link	VERB
eurjchem-701	12	18	with	with	ADP
eurjchem-701	12	19	doxorubicin	doxorubicin	PROPN
eurjchem-701	12	20	iv	iv	PUNCT
eurjchem-701	12	21	to	to	PART
eurjchem-701	12	22	developed	develop	VERB
eurjchem-701	12	23	new	new	ADJ
eurjchem-701	12	24	anticancer	anticancer	NOUN
eurjchem-701	12	25	prodrugs	prodrug	NOUN
eurjchem-701	12	26	for	for	ADP
eurjchem-701	12	27	multidrug	multidrug	NOUN
eurjchem-701	12	28	resistant	resistant	ADJ
eurjchem-701	12	29	(	(	PUNCT
eurjchem-701	12	30	mdr	mdr	NOUN
eurjchem-701	12	31	)	)	PUNCT
eurjchem-701	12	32	cancer	cancer	NOUN
eurjchem-701	12	33	cells	cell	NOUN
eurjchem-701	12	34	.	.	PUNCT
eurjchem-701	13	1	all	all	DET
eurjchem-701	13	2	the	the	DET
eurjchem-701	13	3	synthesized	synthesize	VERB
eurjchem-701	13	4	compounds	compound	NOUN
eurjchem-701	13	5	were	be	AUX
eurjchem-701	13	6	characterized	characterize	VERB
eurjchem-701	13	7	by	by	ADP
eurjchem-701	13	8	spectroscopic	spectroscopic	ADJ
eurjchem-701	13	9	techniques	technique	NOUN
eurjchem-701	13	10	.	.	PUNCT
eurjchem-701	14	1	hela	hela	PROPN
eurjchem-701	14	2	cell	cell	NOUN
eurjchem-701	14	3	line	line	NOUN
eurjchem-701	14	4	ureases	urease	VERB
eurjchem-701	14	5	inhibition	inhibition	VERB
eurjchem-701	14	6	anticancer	anticancer	NOUN
eurjchem-701	14	7	activity	activity	NOUN
eurjchem-701	14	8	prostate	prostate	NOUN
eurjchem-701	14	9	cancer	cancer	NOUN
eurjchem-701	14	10	cell	cell	NOUN
eurjchem-701	14	11	line	line	NOUN
eurjchem-701	14	12	knoevenagel	knoevenagel	NOUN
eurjchem-701	14	13	condensation	condensation	NOUN
eurjchem-701	14	14	dihydropyridine	dihydropyridine	NOUN
eurjchem-701	14	15	derivatives	derivative	NOUN
eurjchem-701	14	16	1	1	NUM
eurjchem-701	14	17	.	.	PUNCT
eurjchem-701	15	1	introduction	introduction	NOUN
eurjchem-701	15	2	pyridine	pyridine	NOUN
eurjchem-701	15	3	derivatives	derivative	NOUN
eurjchem-701	15	4	are	be	AUX
eurjchem-701	15	5	important	important	ADJ
eurjchem-701	15	6	class	class	NOUN
eurjchem-701	15	7	of	of	ADP
eurjchem-701	15	8	n‐heterocyclic	n‐heterocyclic	NOUN
eurjchem-701	15	9	compounds	compound	NOUN
eurjchem-701	15	10	exhibiting	exhibit	VERB
eurjchem-701	15	11	a	a	DET
eurjchem-701	15	12	wide	wide	ADJ
eurjchem-701	15	13	range	range	NOUN
eurjchem-701	15	14	of	of	ADP
eurjchem-701	15	15	biological	biological	ADJ
eurjchem-701	15	16	activities	activity	NOUN
eurjchem-701	15	17	,	,	PUNCT
eurjchem-701	15	18	e.g.	e.g.	ADV
eurjchem-701	15	19	antifungal	antifungal	ADJ
eurjchem-701	16	1	[	[	X
eurjchem-701	16	2	1	1	NUM
eurjchem-701	16	3	]	]	PUNCT
eurjchem-701	16	4	,	,	PUNCT
eurjchem-701	16	5	antibacterial	antibacterial	ADJ
eurjchem-701	16	6	[	[	X
eurjchem-701	16	7	2	2	NUM
eurjchem-701	16	8	]	]	PUNCT
eurjchem-701	16	9	and	and	CCONJ
eurjchem-701	16	10	anticancer	anticancer	NOUN
eurjchem-701	16	11	[	[	X
eurjchem-701	16	12	3	3	NUM
eurjchem-701	16	13	]	]	PUNCT
eurjchem-701	16	14	,	,	PUNCT
eurjchem-701	16	15	etc	etc	X
eurjchem-701	16	16	..	..	X
eurjchem-701	16	17	in	in	ADP
eurjchem-701	16	18	this	this	DET
eurjchem-701	16	19	perspective	perspective	NOUN
eurjchem-701	16	20	,	,	PUNCT
eurjchem-701	16	21	a	a	DET
eurjchem-701	16	22	synthesized	synthesize	VERB
eurjchem-701	16	23	series	series	NOUN
eurjchem-701	16	24	5,6‐dihydropyridine	5,6‐dihydropyridine	NUM
eurjchem-701	16	25	derivatives	derivative	NOUN
eurjchem-701	16	26	8a‐n	8a‐n	PROPN
eurjchem-701	16	27	were	be	AUX
eurjchem-701	16	28	evaluated	evaluate	VERB
eurjchem-701	16	29	as	as	ADP
eurjchem-701	16	30	urease	urease	NOUN
eurjchem-701	16	31	inhibitor	inhibitor	NOUN
eurjchem-701	16	32	and	and	CCONJ
eurjchem-701	16	33	anticancer	anticancer	NOUN
eurjchem-701	16	34	agents	agent	NOUN
eurjchem-701	16	35	[	[	X
eurjchem-701	16	36	4	4	NUM
eurjchem-701	16	37	]	]	PUNCT
eurjchem-701	16	38	.	.	PUNCT
eurjchem-701	17	1	the	the	DET
eurjchem-701	17	2	development	development	NOUN
eurjchem-701	17	3	of	of	ADP
eurjchem-701	17	4	urease	urease	ADJ
eurjchem-701	17	5	inhibitors	inhibitor	NOUN
eurjchem-701	17	6	,	,	PUNCT
eurjchem-701	17	7	usually	usually	ADV
eurjchem-701	17	8	considered	consider	VERB
eurjchem-701	17	9	as	as	ADP
eurjchem-701	17	10	antiulcer	antiulcer	NOUN
eurjchem-701	17	11	agents	agent	NOUN
eurjchem-701	17	12	,	,	PUNCT
eurjchem-701	17	13	carry	carry	VERB
eurjchem-701	17	14	a	a	DET
eurjchem-701	17	15	significant	significant	ADJ
eurjchem-701	17	16	interest	interest	NOUN
eurjchem-701	17	17	for	for	ADP
eurjchem-701	17	18	medicinal	medicinal	ADJ
eurjchem-701	17	19	chemists	chemist	NOUN
eurjchem-701	17	20	.	.	PUNCT
eurjchem-701	18	1	urease	urease	NOUN
eurjchem-701	18	2	is	be	AUX
eurjchem-701	18	3	an	an	DET
eurjchem-701	18	4	enzyme	enzyme	NOUN
eurjchem-701	18	5	that	that	PRON
eurjchem-701	18	6	is	be	AUX
eurjchem-701	18	7	clinically	clinically	ADV
eurjchem-701	18	8	used	use	VERB
eurjchem-701	18	9	as	as	ADP
eurjchem-701	18	10	diagnostic	diagnostic	ADJ
eurjchem-701	18	11	to	to	PART
eurjchem-701	18	12	determine	determine	VERB
eurjchem-701	18	13	the	the	DET
eurjchem-701	18	14	presence	presence	NOUN
eurjchem-701	18	15	of	of	ADP
eurjchem-701	18	16	pathogens	pathogen	NOUN
eurjchem-701	18	17	in	in	ADP
eurjchem-701	18	18	the	the	DET
eurjchem-701	18	19	gastrointestinal	gastrointestinal	ADJ
eurjchem-701	18	20	and	and	CCONJ
eurjchem-701	18	21	urinary	urinary	ADJ
eurjchem-701	18	22	tracts	tract	NOUN
eurjchem-701	18	23	.	.	PUNCT
eurjchem-701	19	1	it	it	PRON
eurjchem-701	19	2	has	have	AUX
eurjchem-701	19	3	been	be	AUX
eurjchem-701	19	4	described	describe	VERB
eurjchem-701	19	5	that	that	SCONJ
eurjchem-701	19	6	the	the	DET
eurjchem-701	19	7	bacterial	bacterial	ADJ
eurjchem-701	19	8	urease	urease	NOUN
eurjchem-701	19	9	causes	cause	VERB
eurjchem-701	19	10	many	many	ADJ
eurjchem-701	19	11	clinically	clinically	ADV
eurjchem-701	19	12	harmful	harmful	ADJ
eurjchem-701	19	13	infections	infection	NOUN
eurjchem-701	19	14	,	,	PUNCT
eurjchem-701	19	15	like	like	ADP
eurjchem-701	19	16	stomach	stomach	NOUN
eurjchem-701	19	17	cancer	cancer	NOUN
eurjchem-701	19	18	,	,	PUNCT
eurjchem-701	19	19	infectious	infectious	ADJ
eurjchem-701	19	20	stones	stone	NOUN
eurjchem-701	19	21	and	and	CCONJ
eurjchem-701	19	22	peptic	peptic	ADJ
eurjchem-701	19	23	ulcer	ulcer	NOUN
eurjchem-701	19	24	formation	formation	NOUN
eurjchem-701	19	25	in	in	ADP
eurjchem-701	19	26	human	human	ADJ
eurjchem-701	19	27	and	and	CCONJ
eurjchem-701	19	28	animal	animal	NOUN
eurjchem-701	19	29	health	health	NOUN
eurjchem-701	20	1	[	[	X
eurjchem-701	20	2	5	5	NUM
eurjchem-701	20	3	]	]	PUNCT
eurjchem-701	20	4	.	.	PUNCT
eurjchem-701	21	1	urease	urease	NOUN
eurjchem-701	21	2	is	be	AUX
eurjchem-701	21	3	also	also	ADV
eurjchem-701	21	4	involved	involve	VERB
eurjchem-701	21	5	in	in	ADP
eurjchem-701	21	6	the	the	DET
eurjchem-701	21	7	other	other	ADJ
eurjchem-701	21	8	pathogenesis	pathogenesis	NOUN
eurjchem-701	21	9	like	like	ADP
eurjchem-701	21	10	hepatic	hepatic	NOUN
eurjchem-701	21	11	come	come	NOUN
eurjchem-701	21	12	,	,	PUNCT
eurjchem-701	21	13	urolithiasis	urolithiasis	NOUN
eurjchem-701	21	14	,	,	PUNCT
eurjchem-701	21	15	urinary	urinary	ADJ
eurjchem-701	21	16	catheter	catheter	NOUN
eurjchem-701	21	17	encrustation	encrustation	NOUN
eurjchem-701	21	18	and	and	CCONJ
eurjchem-701	21	19	oral	oral	ADJ
eurjchem-701	21	20	cavity	cavity	NOUN
eurjchem-701	21	21	infections	infection	NOUN
eurjchem-701	21	22	by	by	ADP
eurjchem-701	21	23	hydrolyzing	hydrolyze	VERB
eurjchem-701	21	24	the	the	DET
eurjchem-701	21	25	salivary	salivary	ADJ
eurjchem-701	21	26	urea	urea	NOUN
eurjchem-701	22	1	[	[	X
eurjchem-701	22	2	6	6	NUM
eurjchem-701	22	3	]	]	PUNCT
eurjchem-701	22	4	.	.	PUNCT
eurjchem-701	23	1	cancer	cancer	NOUN
eurjchem-701	23	2	,	,	PUNCT
eurjchem-701	23	3	an	an	DET
eurjchem-701	23	4	uncontrolled	uncontrolled	ADJ
eurjchem-701	23	5	aggregation	aggregation	NOUN
eurjchem-701	23	6	of	of	ADP
eurjchem-701	23	7	abnormal	abnormal	ADJ
eurjchem-701	23	8	cells	cell	NOUN
eurjchem-701	23	9	is	be	AUX
eurjchem-701	23	10	one	one	NUM
eurjchem-701	23	11	of	of	ADP
eurjchem-701	23	12	the	the	DET
eurjchem-701	23	13	prominent	prominent	ADJ
eurjchem-701	23	14	cause	cause	NOUN
eurjchem-701	23	15	of	of	ADP
eurjchem-701	23	16	human	human	ADJ
eurjchem-701	23	17	mortality	mortality	NOUN
eurjchem-701	23	18	in	in	ADP
eurjchem-701	23	19	the	the	DET
eurjchem-701	23	20	world	world	NOUN
eurjchem-701	23	21	.	.	PUNCT
eurjchem-701	24	1	currently	currently	ADV
eurjchem-701	24	2	available	available	ADJ
eurjchem-701	24	3	chemotherapies	chemotherapy	NOUN
eurjchem-701	24	4	i.e.	i.e.	X
eurjchem-701	24	5	doxorubicin	doxorubicin	PROPN
eurjchem-701	24	6	iv	iv	PROPN
eurjchem-701	24	7	and	and	CCONJ
eurjchem-701	24	8	related	related	ADJ
eurjchem-701	24	9	compounds	compound	NOUN
eurjchem-701	24	10	etc	etc	X
eurjchem-701	24	11	.	.	X
eurjchem-701	24	12	encounter	encounter	VERB
eurjchem-701	24	13	some	some	DET
eurjchem-701	24	14	major	major	ADJ
eurjchem-701	24	15	issues	issue	NOUN
eurjchem-701	24	16	such	such	ADJ
eurjchem-701	24	17	as	as	ADP
eurjchem-701	24	18	cardiotoxicity	cardiotoxicity	NOUN
eurjchem-701	24	19	[	[	X
eurjchem-701	24	20	7	7	NUM
eurjchem-701	24	21	]	]	PUNCT
eurjchem-701	24	22	and	and	CCONJ
eurjchem-701	24	23	multidrug‐resistant	multidrug‐resistant	ADJ
eurjchem-701	24	24	.	.	PUNCT
eurjchem-701	25	1	multiple	multiple	ADJ
eurjchem-701	25	2	drug	drug	NOUN
eurjchem-701	25	3	resistant	resistant	ADJ
eurjchem-701	25	4	(	(	PUNCT
eurjchem-701	25	5	mdr	mdr	NOUN
eurjchem-701	25	6	)	)	PUNCT
eurjchem-701	25	7	mainly	mainly	ADV
eurjchem-701	25	8	occurs	occur	VERB
eurjchem-701	25	9	due	due	ADP
eurjchem-701	25	10	to	to	ADP
eurjchem-701	25	11	the	the	DET
eurjchem-701	25	12	over	over	ADJ
eurjchem-701	25	13	expression	expression	NOUN
eurjchem-701	25	14	of	of	ADP
eurjchem-701	25	15	p‐	p‐	NOUN
eurjchem-701	25	16	glycoprotein	glycoprotein	NOUN
eurjchem-701	25	17	(	(	PUNCT
eurjchem-701	25	18	multidrug	multidrug	VERB
eurjchem-701	25	19	resistance	resistance	NOUN
eurjchem-701	25	20	protein	protein	NOUN
eurjchem-701	25	21	)	)	PUNCT
eurjchem-701	25	22	efflux	efflux	NOUN
eurjchem-701	25	23	pump	pump	NOUN
eurjchem-701	25	24	which	which	PRON
eurjchem-701	25	25	extrude	extrude	VERB
eurjchem-701	25	26	the	the	DET
eurjchem-701	25	27	drugs	drug	NOUN
eurjchem-701	25	28	from	from	ADP
eurjchem-701	25	29	the	the	DET
eurjchem-701	25	30	cell	cell	NOUN
eurjchem-701	25	31	[	[	X
eurjchem-701	25	32	8‐10	8‐10	NUM
eurjchem-701	25	33	]	]	X
eurjchem-701	25	34	.	.	PUNCT
eurjchem-701	26	1	toyota	toyota	PROPN
eurjchem-701	26	2	et	et	PROPN
eurjchem-701	26	3	.	.	PUNCT
eurjchem-701	27	1	al	al	PROPN
eurjchem-701	27	2	.	.	PUNCT
eurjchem-701	28	1	[	[	X
eurjchem-701	28	2	11	11	NUM
eurjchem-701	28	3	]	]	PUNCT
eurjchem-701	28	4	described	describe	VERB
eurjchem-701	28	5	that	that	SCONJ
eurjchem-701	28	6	the	the	DET
eurjchem-701	28	7	multiple	multiple	ADJ
eurjchem-701	28	8	resistant	resistant	ADJ
eurjchem-701	28	9	cells	cell	NOUN
eurjchem-701	28	10	accelerate	accelerate	VERB
eurjchem-701	28	11	the	the	DET
eurjchem-701	28	12	membrane	membrane	NOUN
eurjchem-701	28	13	transports	transport	NOUN
eurjchem-701	28	14	,	,	PUNCT
eurjchem-701	28	15	especially	especially	ADV
eurjchem-701	28	16	the	the	DET
eurjchem-701	28	17	excretion	excretion	NOUN
eurjchem-701	28	18	process	process	NOUN
eurjchem-701	28	19	which	which	PRON
eurjchem-701	28	20	lower	lower	VERB
eurjchem-701	28	21	the	the	DET
eurjchem-701	28	22	drug	drug	NOUN
eurjchem-701	28	23	concentration	concentration	NOUN
eurjchem-701	28	24	in	in	ADP
eurjchem-701	28	25	the	the	DET
eurjchem-701	28	26	cells	cell	NOUN
eurjchem-701	28	27	.	.	PUNCT
eurjchem-701	29	1	they	they	PRON
eurjchem-701	29	2	prepared	prepare	VERB
eurjchem-701	29	3	1,4‐	1,4‐	NUM
eurjchem-701	29	4	dihydropyridine	dihydropyridine	NOUN
eurjchem-701	29	5	,	,	PUNCT
eurjchem-701	29	6	calcium	calcium	NOUN
eurjchem-701	29	7	channel	channel	NOUN
eurjchem-701	29	8	antagonist	antagonist	NOUN
eurjchem-701	29	9	,	,	PUNCT
eurjchem-701	29	10	(	(	PUNCT
eurjchem-701	29	11	structure	structure	NOUN
eurjchem-701	29	12	1	1	NUM
eurjchem-701	29	13	,	,	PUNCT
eurjchem-701	29	14	figure	figure	NOUN
eurjchem-701	29	15	1	1	NUM
eurjchem-701	29	16	)	)	PUNCT
eurjchem-701	29	17	derivatives	derivative	NOUN
eurjchem-701	29	18	which	which	PRON
eurjchem-701	29	19	were	be	AUX
eurjchem-701	29	20	used	use	VERB
eurjchem-701	29	21	in	in	ADP
eurjchem-701	29	22	combination	combination	NOUN
eurjchem-701	29	23	with	with	ADP
eurjchem-701	29	24	commercially	commercially	ADV
eurjchem-701	29	25	available	available	ADJ
eurjchem-701	29	26	drugs	drug	NOUN
eurjchem-701	29	27	e.g.	e.g.	ADV
eurjchem-701	29	28	doxorubicin	doxorubicin	PROPN
eurjchem-701	29	29	iv	iv	NUM
eurjchem-701	29	30	etc	etc	X
eurjchem-701	29	31	.	.	X
eurjchem-701	29	32	to	to	PART
eurjchem-701	29	33	increase	increase	VERB
eurjchem-701	29	34	the	the	DET
eurjchem-701	29	35	anticancer	anticancer	NOUN
eurjchem-701	29	36	drug	drug	NOUN
eurjchem-701	29	37	concentration	concentration	NOUN
eurjchem-701	29	38	in	in	ADP
eurjchem-701	29	39	cancel	cancel	VERB
eurjchem-701	29	40	cells	cell	NOUN
eurjchem-701	29	41	by	by	ADP
eurjchem-701	29	42	inhibiting	inhibit	VERB
eurjchem-701	29	43	extracellular	extracellular	ADJ
eurjchem-701	29	44	excretion	excretion	NOUN
eurjchem-701	29	45	process	process	NOUN
eurjchem-701	29	46	of	of	ADP
eurjchem-701	29	47	cell	cell	NOUN
eurjchem-701	29	48	.	.	PUNCT
eurjchem-701	30	1	abadi	abadi	PROPN
eurjchem-701	30	2	a.	a.	PROPN
eurjchem-701	30	3	h.	h.	PROPN
eurjchem-701	30	4	et	et	PROPN
eurjchem-701	30	5	al	al	PROPN
eurjchem-701	30	6	.	.	PUNCT
eurjchem-701	31	1	[	[	X
eurjchem-701	31	2	12	12	NUM
eurjchem-701	31	3	]	]	PUNCT
eurjchem-701	31	4	reported	report	VERB
eurjchem-701	31	5	compound	compound	NOUN
eurjchem-701	31	6	2	2	NUM
eurjchem-701	31	7	as	as	ADP
eurjchem-701	31	8	inhibitor	inhibitor	NOUN
eurjchem-701	31	9	of	of	ADP
eurjchem-701	31	10	oncogene	oncogene	NOUN
eurjchem-701	31	11	serine	serine	NOUN
eurjchem-701	31	12	/	/	SYM
eurjchem-701	31	13	threonine	threonine	ADJ
eurjchem-701	31	14	kinase	kinase	PROPN
eurjchem-701	31	15	pim‐i	pim‐i	PROPN
eurjchem-701	31	16	,	,	PUNCT
eurjchem-701	31	17	an	an	DET
eurjchem-701	31	18	enzyme	enzyme	NOUN
eurjchem-701	31	19	over	over	ADV
eurjchem-701	31	20	expressed	express	VERB
eurjchem-701	31	21	in	in	ADP
eurjchem-701	31	22	many	many	ADJ
eurjchem-701	31	23	cancer	cancer	NOUN
eurjchem-701	31	24	cells	cell	NOUN
eurjchem-701	31	25	line	line	NOUN
eurjchem-701	31	26	.	.	PUNCT
eurjchem-701	32	1	in	in	ADP
eurjchem-701	32	2	the	the	DET
eurjchem-701	32	3	view	view	NOUN
eurjchem-701	32	4	of	of	ADP
eurjchem-701	32	5	these	these	DET
eurjchem-701	32	6	antitumor	antitumor	PROPN
eurjchem-701	32	7	investigations	investigation	NOUN
eurjchem-701	32	8	in	in	ADP
eurjchem-701	32	9	drug	drug	NOUN
eurjchem-701	32	10	resistant	resistant	ADJ
eurjchem-701	32	11	cancer	cancer	NOUN
eurjchem-701	32	12	cells	cell	NOUN
eurjchem-701	32	13	,	,	PUNCT
eurjchem-701	32	14	we	we	PRON
eurjchem-701	32	15	have	have	AUX
eurjchem-701	32	16	screened	screen	VERB
eurjchem-701	32	17	our	our	PRON
eurjchem-701	32	18	polyfunctional	polyfunctional	ADJ
eurjchem-701	32	19	dihydropydridine	dihydropydridine	NOUN
eurjchem-701	32	20	compounds	compound	NOUN
eurjchem-701	32	21	(	(	PUNCT
eurjchem-701	32	22	structure	structure	NOUN
eurjchem-701	32	23	3	3	NUM
eurjchem-701	32	24	)	)	PUNCT
eurjchem-701	32	25	for	for	ADP
eurjchem-701	32	26	anticancer	anticancer	NOUN
eurjchem-701	32	27	activity	activity	NOUN
eurjchem-701	32	28	(	(	PUNCT
eurjchem-701	32	29	figure	figure	NOUN
eurjchem-701	32	30	1	1	NUM
eurjchem-701	32	31	)	)	PUNCT
eurjchem-701	32	32	.	.	PUNCT
eurjchem-701	33	1	figure	figure	VERB
eurjchem-701	33	2	1	1	NUM
eurjchem-701	33	3	.	.	NOUN
eurjchem-701	33	4	5,6‐dihydropyridine	5,6‐dihydropyridine	NUM
eurjchem-701	33	5	,	,	PUNCT
eurjchem-701	33	6	1	1	NUM
eurjchem-701	33	7	,	,	PUNCT
eurjchem-701	33	8	and	and	CCONJ
eurjchem-701	33	9	its	its	PRON
eurjchem-701	33	10	related	related	ADJ
eurjchem-701	33	11	compounds	compound	NOUN
eurjchem-701	33	12	.	.	PUNCT
eurjchem-701	34	1	50	50	NUM
eurjchem-701	34	2	hameed	hameed	NOUN
eurjchem-701	34	3	et	et	PROPN
eurjchem-701	34	4	al	al	PROPN
eurjchem-701	34	5	.	.	PUNCT
eurjchem-701	34	6	/	/	SYM
eurjchem-701	34	7	european	european	PROPN
eurjchem-701	34	8	journal	journal	PROPN
eurjchem-701	34	9	of	of	ADP
eurjchem-701	34	10	chemistry	chemistry	NOUN
eurjchem-701	34	11	4	4	NUM
eurjchem-701	34	12	(	(	PUNCT
eurjchem-701	34	13	1	1	NUM
eurjchem-701	34	14	)	)	PUNCT
eurjchem-701	34	15	(	(	PUNCT
eurjchem-701	34	16	2013	2013	NUM
eurjchem-701	34	17	)	)	PUNCT
eurjchem-701	34	18	49‐52	49‐52	NUM
eurjchem-701	34	19	table	table	NOUN
eurjchem-701	34	20	1	1	NUM
eurjchem-701	34	21	.	.	PUNCT
eurjchem-701	34	22	different	different	ADJ
eurjchem-701	34	23	substituted	substitute	VERB
eurjchem-701	34	24	phenyl	phenyl	NOUN
eurjchem-701	34	25	groups	group	NOUN
eurjchem-701	34	26	on	on	ADP
eurjchem-701	34	27	core	core	NOUN
eurjchem-701	34	28	dihydropyridine	dihydropyridine	NOUN
eurjchem-701	34	29	ring	ring	NOUN
eurjchem-701	34	30	.	.	PUNCT
eurjchem-701	35	1	entry	entry	NOUN
eurjchem-701	35	2	aryl	aryl	NOUN
eurjchem-701	35	3	group	group	NOUN
eurjchem-701	35	4	(	(	PUNCT
eurjchem-701	35	5	ar‐	ar‐	NOUN
eurjchem-701	35	6	)	)	PUNCT
eurjchem-701	35	7	yield	yield	NOUN
eurjchem-701	35	8	(	(	PUNCT
eurjchem-701	35	9	%	%	NOUN
eurjchem-701	35	10	)	)	PUNCT
eurjchem-701	35	11	entry	entry	NOUN
eurjchem-701	35	12	aryl	aryl	NOUN
eurjchem-701	35	13	group	group	NOUN
eurjchem-701	35	14	(	(	PUNCT
eurjchem-701	35	15	ar‐	ar‐	NOUN
eurjchem-701	35	16	)	)	PUNCT
eurjchem-701	35	17	yield	yield	NOUN
eurjchem-701	35	18	(	(	PUNCT
eurjchem-701	35	19	%	%	NOUN
eurjchem-701	35	20	)	)	PUNCT
eurjchem-701	35	21	1	1	NUM
eurjchem-701	35	22	br	br	NOUN
eurjchem-701	35	23	8a	8a	NUM
eurjchem-701	35	24	90	90	NUM
eurjchem-701	35	25	8	8	NUM
eurjchem-701	35	26	80	80	NUM
eurjchem-701	35	27	2	2	NUM
eurjchem-701	35	28	90	90	NUM
eurjchem-701	35	29	9	9	NUM
eurjchem-701	35	30	75	75	NUM
eurjchem-701	35	31	3	3	NUM
eurjchem-701	35	32	98	98	NUM
eurjchem-701	35	33	10	10	NUM
eurjchem-701	35	34	75	75	NUM
eurjchem-701	35	35	4	4	NUM
eurjchem-701	35	36	65	65	NUM
eurjchem-701	35	37	11	11	NUM
eurjchem-701	35	38	meo	meo	X
eurjchem-701	35	39	8k	8k	NOUN
eurjchem-701	35	40	95	95	NUM
eurjchem-701	35	41	5	5	NUM
eurjchem-701	35	42	89	89	NUM
eurjchem-701	35	43	12	12	NUM
eurjchem-701	35	44	75	75	NUM
eurjchem-701	35	45	6	6	NUM
eurjchem-701	35	46	90	90	NUM
eurjchem-701	35	47	13	13	NUM
eurjchem-701	35	48	93	93	NUM
eurjchem-701	35	49	7	7	NUM
eurjchem-701	35	50	95	95	NUM
eurjchem-701	35	51	14	14	NUM
eurjchem-701	35	52	52	52	NUM
eurjchem-701	35	53	(	(	PUNCT
eurjchem-701	35	54	2:1	2:1	NUM
eurjchem-701	35	55	ratio	ratio	NOUN
eurjchem-701	35	56	)	)	PUNCT
eurjchem-701	35	57	ar	ar	NOUN
eurjchem-701	35	58	o	o	PROPN
eurjchem-701	35	59	h3c	h3c	PROPN
eurjchem-701	35	60	ar	ar	PROPN
eurjchem-701	35	61	h3c	h3c	PROPN
eurjchem-701	35	62	nc	nc	PROPN
eurjchem-701	35	63	cn	cn	PROPN
eurjchem-701	35	64	nh(tms)2	nh(tms)2	AUX
eurjchem-701	35	65	glacial	glacial	ADJ
eurjchem-701	35	66	acetic	acetic	ADJ
eurjchem-701	35	67	acid	acid	NOUN
eurjchem-701	35	68	toluene	toluene	NOUN
eurjchem-701	35	69	,	,	PUNCT
eurjchem-701	35	70	65	65	NUM
eurjchem-701	35	71	-	-	SYM
eurjchem-701	35	72	70	70	NUM
eurjchem-701	35	73	oc	oc	ADP
eurjchem-701	35	74	50	50	NUM
eurjchem-701	35	75	-	-	SYM
eurjchem-701	35	76	95	95	NUM
eurjchem-701	35	77	%	%	NOUN
eurjchem-701	35	78	tbaf	tbaf	ADJ
eurjchem-701	35	79	.	.	PUNCT
eurjchem-701	36	1	3h2o	3h2o	NUM
eurjchem-701	36	2	(	(	PUNCT
eurjchem-701	36	3	neat	neat	ADJ
eurjchem-701	36	4	)	)	PUNCT
eurjchem-701	36	5	80	80	NUM
eurjchem-701	36	6	-	-	SYM
eurjchem-701	36	7	85	85	NUM
eurjchem-701	36	8	oc	oc	NOUN
eurjchem-701	36	9	cn	cn	PROPN
eurjchem-701	37	1	cn	cn	PROPN
eurjchem-701	37	2	n	n	PROPN
eurjchem-701	37	3	h	h	NOUN
eurjchem-701	38	1	cn	cn	PROPN
eurjchem-701	38	2	cn	cn	PROPN
eurjchem-701	38	3	cn	cn	PROPN
eurjchem-701	38	4	ar	ar	PROPN
eurjchem-701	38	5	n	n	PROPN
eurjchem-701	38	6	h	h	NOUN
eurjchem-701	39	1	cn	cn	PROPN
eurjchem-701	39	2	cn	cn	PROPN
eurjchem-701	39	3	cn	cn	PROPN
eurjchem-701	39	4	ar	ar	PROPN
eurjchem-701	39	5	(	(	PUNCT
eurjchem-701	39	6	nbu)4n	nbu)4n	NOUN
eurjchem-701	39	7	b	b	NOUN
eurjchem-701	39	8	)	)	PUNCT
eurjchem-701	39	9	acidic	acidic	ADJ
eurjchem-701	39	10	work	work	NOUN
eurjchem-701	39	11	up	up	ADP
eurjchem-701	39	12	2n	2n	NUM
eurjchem-701	39	13	hcl	hcl	PROPN
eurjchem-701	39	14	(	(	PUNCT
eurjchem-701	39	15	aq	aq	NOUN
eurjchem-701	39	16	)	)	PUNCT
eurjchem-701	40	1	n	n	PRON
eurjchem-701	40	2	h	h	NOUN
eurjchem-701	41	1	cn	cn	PROPN
eurjchem-701	41	2	cn	cn	PROPN
eurjchem-701	41	3	cn	cn	PROPN
eurjchem-701	41	4	ar	ar	PROPN
eurjchem-701	41	5	a	a	PROPN
eurjchem-701	41	6	)	)	PUNCT
eurjchem-701	41	7	ar	ar	PROPN
eurjchem-701	41	8	h3c	h3c	PROPN
eurjchem-701	41	9	ar	ar	PROPN
eurjchem-701	41	10	h3c	h3c	PROPN
eurjchem-701	41	11	ar	ar	PROPN
eurjchem-701	41	12	h3c	h3c	VERB
eurjchem-701	41	13	5	5	NUM
eurjchem-701	41	14	6	6	NUM
eurjchem-701	41	15	7	7	NUM
eurjchem-701	41	16	8a-8n	8a-8n	NUM
eurjchem-701	41	17	9o	9o	NOUN
eurjchem-701	41	18	ar	ar	NOUN
eurjchem-701	41	19	=	=	NOUN
eurjchem-701	41	20	substituted	substitute	VERB
eurjchem-701	41	21	aromatic	aromatic	ADJ
eurjchem-701	41	22	ring	ring	NOUN
eurjchem-701	41	23	(	(	PUNCT
eurjchem-701	41	24	h	h	NOUN
eurjchem-701	41	25	,	,	PUNCT
eurjchem-701	41	26	ch3	ch3	PROPN
eurjchem-701	41	27	,	,	PUNCT
eurjchem-701	41	28	i	i	PROPN
eurjchem-701	41	29	,	,	PUNCT
eurjchem-701	41	30	br	br	PROPN
eurjchem-701	41	31	,	,	PUNCT
eurjchem-701	41	32	cl	cl	NOUN
eurjchem-701	41	33	,	,	PUNCT
eurjchem-701	41	34	f	f	PROPN
eurjchem-701	41	35	,	,	PUNCT
eurjchem-701	41	36	och3	och3	ADJ
eurjchem-701	41	37	,	,	PUNCT
eurjchem-701	41	38	oh	oh	INTJ
eurjchem-701	41	39	,	,	PUNCT
eurjchem-701	41	40	no2	no2	NOUN
eurjchem-701	41	41	)	)	PUNCT
eurjchem-701	41	42	1	1	NUM
eurjchem-701	41	43	2	2	NUM
eurjchem-701	41	44	3	3	NUM
eurjchem-701	41	45	4	4	NUM
eurjchem-701	41	46	5	5	NUM
eurjchem-701	41	47	6	6	NUM
eurjchem-701	41	48	1	1	NUM
eurjchem-701	41	49	2	2	NUM
eurjchem-701	41	50	3	3	NUM
eurjchem-701	41	51	4	4	NUM
eurjchem-701	41	52	5	5	NUM
eurjchem-701	41	53	6	6	NUM
eurjchem-701	41	54	scheme	scheme	NOUN
eurjchem-701	41	55	1	1	NUM
eurjchem-701	41	56	to	to	PART
eurjchem-701	41	57	pursue	pursue	VERB
eurjchem-701	41	58	the	the	DET
eurjchem-701	41	59	interest	interest	NOUN
eurjchem-701	41	60	,	,	PUNCT
eurjchem-701	41	61	we	we	PRON
eurjchem-701	41	62	have	have	AUX
eurjchem-701	41	63	developed	develop	VERB
eurjchem-701	41	64	a	a	DET
eurjchem-701	41	65	solvent‐free	solvent‐free	NOUN
eurjchem-701	41	66	,	,	PUNCT
eurjchem-701	41	67	cost‐effective	cost‐effective	ADJ
eurjchem-701	41	68	and	and	CCONJ
eurjchem-701	41	69	scalable	scalable	ADJ
eurjchem-701	41	70	method	method	NOUN
eurjchem-701	41	71	for	for	ADP
eurjchem-701	41	72	the	the	DET
eurjchem-701	41	73	preparation	preparation	NOUN
eurjchem-701	41	74	of	of	ADP
eurjchem-701	41	75	desired	desire	VERB
eurjchem-701	41	76	compounds	compound	NOUN
eurjchem-701	41	77	8a‐n	8a‐n	PROPN
eurjchem-701	41	78	(	(	PUNCT
eurjchem-701	41	79	scheme	scheme	NOUN
eurjchem-701	41	80	1	1	NUM
eurjchem-701	41	81	)	)	PUNCT
eurjchem-701	42	1	[	[	X
eurjchem-701	42	2	4	4	NUM
eurjchem-701	42	3	]	]	PUNCT
eurjchem-701	42	4	.	.	PUNCT
eurjchem-701	43	1	the	the	DET
eurjchem-701	43	2	highly	highly	ADV
eurjchem-701	43	3	functionalized	functionalize	VERB
eurjchem-701	43	4	5,6‐dihydropyridine	5,6‐dihydropyridine	NUM
eurjchem-701	43	5	derivatives	derivative	NOUN
eurjchem-701	43	6	8a‐n	8a‐n	NOUN
eurjchem-701	43	7	were	be	AUX
eurjchem-701	43	8	synthesized	synthesize	VERB
eurjchem-701	43	9	from	from	ADP
eurjchem-701	43	10	corresponding	correspond	VERB
eurjchem-701	43	11	alkylidenemalononitrile	alkylidenemalononitrile	ADJ
eurjchem-701	43	12	6	6	NUM
eurjchem-701	43	13	by	by	ADP
eurjchem-701	43	14	dimerization	dimerization	NOUN
eurjchem-701	43	15	in	in	ADP
eurjchem-701	43	16	good	good	ADJ
eurjchem-701	43	17	to	to	ADP
eurjchem-701	43	18	excellent	excellent	ADJ
eurjchem-701	43	19	yield	yield	NOUN
eurjchem-701	43	20	(	(	PUNCT
eurjchem-701	43	21	52‐95	52‐95	NUM
eurjchem-701	43	22	%	%	NOUN
eurjchem-701	43	23	)	)	PUNCT
eurjchem-701	43	24	.	.	PUNCT
eurjchem-701	44	1	the	the	DET
eurjchem-701	44	2	reaction	reaction	NOUN
eurjchem-701	44	3	was	be	AUX
eurjchem-701	44	4	promoted	promote	VERB
eurjchem-701	44	5	with	with	ADP
eurjchem-701	44	6	neat	neat	ADJ
eurjchem-701	44	7	tetrabutylammonium	tetrabutylammonium	NOUN
eurjchem-701	44	8	fluoride	fluoride	NOUN
eurjchem-701	44	9	trihydrate	trihydrate	NOUN
eurjchem-701	44	10	(	(	PUNCT
eurjchem-701	44	11	tbaf.3h2o	tbaf.3h2o	PROPN
eurjchem-701	44	12	)	)	PUNCT
eurjchem-701	44	13	under	under	ADP
eurjchem-701	44	14	solvent	solvent	ADJ
eurjchem-701	44	15	free	free	ADJ
eurjchem-701	44	16	conditions	condition	NOUN
eurjchem-701	44	17	to	to	PART
eurjchem-701	44	18	develop	develop	VERB
eurjchem-701	44	19	an	an	DET
eurjchem-701	44	20	ecofriendly	ecofriendly	ADJ
eurjchem-701	44	21	methodology	methodology	NOUN
eurjchem-701	44	22	.	.	PUNCT
eurjchem-701	45	1	the	the	DET
eurjchem-701	45	2	final	final	ADJ
eurjchem-701	45	3	compounds	compound	NOUN
eurjchem-701	45	4	(	(	PUNCT
eurjchem-701	45	5	8a‐	8a‐	NUM
eurjchem-701	45	6	n	n	CCONJ
eurjchem-701	45	7	)	)	PUNCT
eurjchem-701	45	8	were	be	AUX
eurjchem-701	45	9	evaluated	evaluate	VERB
eurjchem-701	45	10	for	for	ADP
eurjchem-701	45	11	antiurease	antiurease	NOUN
eurjchem-701	45	12	and	and	CCONJ
eurjchem-701	45	13	anticancer	anticancer	NOUN
eurjchem-701	45	14	activities	activity	NOUN
eurjchem-701	45	15	.	.	PUNCT
eurjchem-701	46	1	the	the	DET
eurjchem-701	46	2	results	result	NOUN
eurjchem-701	46	3	showed	show	VERB
eurjchem-701	46	4	a	a	DET
eurjchem-701	46	5	wide	wide	ADJ
eurjchem-701	46	6	range	range	NOUN
eurjchem-701	46	7	of	of	ADP
eurjchem-701	46	8	both	both	DET
eurjchem-701	46	9	activities	activity	NOUN
eurjchem-701	46	10	depending	depend	VERB
eurjchem-701	46	11	upon	upon	SCONJ
eurjchem-701	46	12	the	the	DET
eurjchem-701	46	13	substituents	substituent	NOUN
eurjchem-701	46	14	present	present	ADJ
eurjchem-701	46	15	on	on	ADP
eurjchem-701	46	16	the	the	DET
eurjchem-701	46	17	phenyl	phenyl	NOUN
eurjchem-701	46	18	rings	ring	NOUN
eurjchem-701	46	19	.	.	PUNCT
eurjchem-701	47	1	2	2	X
eurjchem-701	47	2	.	.	X
eurjchem-701	47	3	experimental	experimental	ADJ
eurjchem-701	47	4	2.1	2.1	NUM
eurjchem-701	47	5	.	.	PUNCT
eurjchem-701	47	6	general	general	ADJ
eurjchem-701	47	7	procedure	procedure	NOUN
eurjchem-701	47	8	for	for	ADP
eurjchem-701	47	9	5,6‐dihydropyridine	5,6‐dihydropyridine	NUM
eurjchem-701	47	10	derivatives	derivative	NOUN
eurjchem-701	47	11	synthesis	synthesis	NOUN
eurjchem-701	47	12	(	(	PUNCT
eurjchem-701	47	13	8a‐n	8a‐n	VERB
eurjchem-701	47	14	)	)	PUNCT
eurjchem-701	47	15	to	to	ADP
eurjchem-701	47	16	an	an	DET
eurjchem-701	47	17	oven	oven	NOUN
eurjchem-701	47	18	dried	dry	VERB
eurjchem-701	47	19	screw‐capped	screw‐cappe	VERB
eurjchem-701	47	20	vial	vial	ADJ
eurjchem-701	47	21	,	,	PUNCT
eurjchem-701	47	22	corresponding	correspond	VERB
eurjchem-701	47	23	alkylidenemalononitrile	alkylidenemalononitrile	ADJ
eurjchem-701	47	24	(	(	PUNCT
eurjchem-701	47	25	1.0	1.0	NUM
eurjchem-701	47	26	equiv	equiv	NOUN
eurjchem-701	47	27	)	)	PUNCT
eurjchem-701	47	28	and	and	CCONJ
eurjchem-701	47	29	neat	neat	ADJ
eurjchem-701	47	30	tbaf.3h2o	tbaf.3h2o	NOUN
eurjchem-701	47	31	(	(	PUNCT
eurjchem-701	47	32	1.0	1.0	NUM
eurjchem-701	47	33	equiv	equiv	NOUN
eurjchem-701	47	34	)	)	PUNCT
eurjchem-701	47	35	was	be	AUX
eurjchem-701	47	36	added	add	VERB
eurjchem-701	47	37	along	along	ADP
eurjchem-701	47	38	with	with	ADP
eurjchem-701	47	39	magnetic	magnetic	ADJ
eurjchem-701	47	40	stirrer	stirrer	ADJ
eurjchem-701	47	41	bar	bar	NOUN
eurjchem-701	47	42	.	.	PUNCT
eurjchem-701	48	1	the	the	DET
eurjchem-701	48	2	resulting	result	VERB
eurjchem-701	48	3	mixture	mixture	NOUN
eurjchem-701	48	4	was	be	AUX
eurjchem-701	48	5	heated	heat	VERB
eurjchem-701	48	6	at	at	ADP
eurjchem-701	48	7	85‐90	85‐90	NUM
eurjchem-701	48	8	oc	oc	NOUN
eurjchem-701	48	9	for	for	ADP
eurjchem-701	48	10	15	15	NUM
eurjchem-701	48	11	h.	h.	NOUN
eurjchem-701	48	12	then	then	ADV
eurjchem-701	48	13	,	,	PUNCT
eurjchem-701	48	14	the	the	DET
eurjchem-701	48	15	reaction	reaction	NOUN
eurjchem-701	48	16	mixture	mixture	NOUN
eurjchem-701	48	17	was	be	AUX
eurjchem-701	48	18	cooled	cool	VERB
eurjchem-701	48	19	to	to	ADP
eurjchem-701	48	20	room	room	NOUN
eurjchem-701	48	21	temperature	temperature	NOUN
eurjchem-701	48	22	and	and	CCONJ
eurjchem-701	48	23	further	far	ADV
eurjchem-701	48	24	diluted	dilute	VERB
eurjchem-701	48	25	with	with	ADP
eurjchem-701	48	26	dioxane	dioxane	NOUN
eurjchem-701	48	27	(	(	PUNCT
eurjchem-701	48	28	2‐3	2‐3	NUM
eurjchem-701	48	29	ml	ml	NOUN
eurjchem-701	48	30	)	)	PUNCT
eurjchem-701	48	31	.	.	PUNCT
eurjchem-701	49	1	1.0	1.0	NUM
eurjchem-701	49	2	m	m	PROPN
eurjchem-701	49	3	hcl	hcl	PROPN
eurjchem-701	49	4	(	(	PUNCT
eurjchem-701	49	5	100	100	NUM
eurjchem-701	49	6	ml	ml	NOUN
eurjchem-701	49	7	)	)	PUNCT
eurjchem-701	49	8	aqueous	aqueous	ADJ
eurjchem-701	49	9	solution	solution	NOUN
eurjchem-701	49	10	was	be	AUX
eurjchem-701	49	11	then	then	ADV
eurjchem-701	49	12	added	add	VERB
eurjchem-701	49	13	to	to	PART
eurjchem-701	49	14	remove	remove	VERB
eurjchem-701	49	15	excess	excess	ADJ
eurjchem-701	49	16	tbaf	tbaf	ADJ
eurjchem-701	49	17	reagent	reagent	NOUN
eurjchem-701	49	18	.	.	PUNCT
eurjchem-701	50	1	the	the	DET
eurjchem-701	50	2	resulting	result	VERB
eurjchem-701	50	3	suspension	suspension	NOUN
eurjchem-701	50	4	was	be	AUX
eurjchem-701	50	5	stirred	stir	VERB
eurjchem-701	50	6	for	for	ADP
eurjchem-701	50	7	additional	additional	ADJ
eurjchem-701	50	8	5	5	NUM
eurjchem-701	50	9	min	min	NOUN
eurjchem-701	50	10	for	for	ADP
eurjchem-701	50	11	complete	complete	ADJ
eurjchem-701	50	12	precipitation	precipitation	NOUN
eurjchem-701	50	13	.	.	PUNCT
eurjchem-701	51	1	the	the	DET
eurjchem-701	51	2	precipitate	precipitate	NOUN
eurjchem-701	51	3	was	be	AUX
eurjchem-701	51	4	filtered	filter	VERB
eurjchem-701	51	5	and	and	CCONJ
eurjchem-701	51	6	washed	wash	VERB
eurjchem-701	51	7	with	with	ADP
eurjchem-701	51	8	more	more	ADJ
eurjchem-701	51	9	1.0	1.0	NUM
eurjchem-701	51	10	m	m	NOUN
eurjchem-701	51	11	hcl	hcl	PROPN
eurjchem-701	51	12	to	to	PART
eurjchem-701	51	13	give	give	VERB
eurjchem-701	51	14	the	the	DET
eurjchem-701	51	15	pure	pure	ADJ
eurjchem-701	51	16	compounds	compound	NOUN
eurjchem-701	51	17	8a‐n	8a‐n	PRON
eurjchem-701	51	18	good	good	ADJ
eurjchem-701	51	19	to	to	ADP
eurjchem-701	51	20	excellent	excellent	ADJ
eurjchem-701	51	21	yield	yield	NOUN
eurjchem-701	51	22	(	(	PUNCT
eurjchem-701	51	23	52‐95	52‐95	NUM
eurjchem-701	51	24	%	%	NOUN
eurjchem-701	51	25	)	)	PUNCT
eurjchem-701	51	26	.	.	PUNCT
eurjchem-701	52	1	the	the	DET
eurjchem-701	52	2	structure	structure	NOUN
eurjchem-701	52	3	of	of	ADP
eurjchem-701	52	4	all	all	DET
eurjchem-701	52	5	dihydropyridine	dihydropyridine	NOUN
eurjchem-701	52	6	derivatives	derivative	NOUN
eurjchem-701	52	7	(	(	PUNCT
eurjchem-701	52	8	table	table	NOUN
eurjchem-701	52	9	1	1	NUM
eurjchem-701	52	10	)	)	PUNCT
eurjchem-701	52	11	was	be	AUX
eurjchem-701	52	12	confirmed	confirm	VERB
eurjchem-701	52	13	with	with	ADP
eurjchem-701	52	14	different	different	ADJ
eurjchem-701	52	15	spectroscopic	spectroscopic	ADJ
eurjchem-701	52	16	techniques	technique	NOUN
eurjchem-701	52	17	including	include	VERB
eurjchem-701	52	18	1h	1h	NUM
eurjchem-701	52	19	nmr	nmr	NOUN
eurjchem-701	52	20	,	,	PUNCT
eurjchem-701	52	21	13c	13c	NOUN
eurjchem-701	52	22	nmr	nmr	NOUN
eurjchem-701	52	23	,	,	PUNCT
eurjchem-701	52	24	ei‐hrms	ei‐hrm	NOUN
eurjchem-701	52	25	and	and	CCONJ
eurjchem-701	52	26	ir	ir	PROPN
eurjchem-701	52	27	spectroscopy	spectroscopy	VERB
eurjchem-701	52	28	[	[	X
eurjchem-701	52	29	4	4	NUM
eurjchem-701	52	30	]	]	PUNCT
eurjchem-701	52	31	.	.	PUNCT
eurjchem-701	53	1	all	all	DET
eurjchem-701	53	2	the	the	DET
eurjchem-701	53	3	synthesized	synthesize	VERB
eurjchem-701	53	4	compounds	compound	NOUN
eurjchem-701	53	5	were	be	AUX
eurjchem-701	53	6	then	then	ADV
eurjchem-701	53	7	subject	subject	ADJ
eurjchem-701	53	8	to	to	ADP
eurjchem-701	53	9	biological	biological	ADJ
eurjchem-701	53	10	evaluation	evaluation	NOUN
eurjchem-701	53	11	.	.	PUNCT
eurjchem-701	54	1	2.2	2.2	NUM
eurjchem-701	54	2	.	.	PUNCT
eurjchem-701	55	1	urease	urease	VERB
eurjchem-701	55	2	inhibition	inhibition	NOUN
eurjchem-701	55	3	assay	assay	VERB
eurjchem-701	55	4	(	(	PUNCT
eurjchem-701	55	5	in	in	ADP
eurjchem-701	55	6	vitro	vitro	X
eurjchem-701	55	7	)	)	PUNCT
eurjchem-701	55	8	the	the	DET
eurjchem-701	55	9	mixture	mixture	NOUN
eurjchem-701	55	10	consists	consist	VERB
eurjchem-701	55	11	of	of	ADP
eurjchem-701	55	12	the	the	DET
eurjchem-701	55	13	solution	solution	NOUN
eurjchem-701	55	14	of	of	ADP
eurjchem-701	55	15	25	25	NUM
eurjchem-701	55	16	μl	μl	PRON
eurjchem-701	55	17	enzyme	enzyme	NOUN
eurjchem-701	55	18	(	(	PUNCT
eurjchem-701	55	19	jack	jack	NOUN
eurjchem-701	55	20	bean	bean	PROPN
eurjchem-701	55	21	urease	urease	PROPN
eurjchem-701	55	22	)	)	PUNCT
eurjchem-701	55	23	and	and	CCONJ
eurjchem-701	55	24	55	55	NUM
eurjchem-701	55	25	μl	μl	NOUN
eurjchem-701	55	26	of	of	ADP
eurjchem-701	55	27	buffers	buffer	NOUN
eurjchem-701	55	28	having	have	VERB
eurjchem-701	55	29	100	100	NUM
eurjchem-701	55	30	mm	mm	NUM
eurjchem-701	55	31	urea	urea	NOUN
eurjchem-701	55	32	.	.	PUNCT
eurjchem-701	56	1	it	it	PRON
eurjchem-701	56	2	was	be	AUX
eurjchem-701	56	3	then	then	ADV
eurjchem-701	56	4	incubated	incubate	VERB
eurjchem-701	56	5	with	with	ADP
eurjchem-701	56	6	5	5	NUM
eurjchem-701	56	7	μl	μl	NOUN
eurjchem-701	56	8	of	of	ADP
eurjchem-701	56	9	test	test	NOUN
eurjchem-701	56	10	compounds	compound	NOUN
eurjchem-701	56	11	(	(	PUNCT
eurjchem-701	56	12	0.5	0.5	NUM
eurjchem-701	56	13	mm	mm	NOUN
eurjchem-701	56	14	concentration	concentration	NOUN
eurjchem-701	56	15	)	)	PUNCT
eurjchem-701	56	16	at	at	ADP
eurjchem-701	56	17	30	30	NUM
eurjchem-701	56	18	°	°	ADP
eurjchem-701	56	19	c	c	NOUN
eurjchem-701	56	20	for	for	ADP
eurjchem-701	56	21	15	15	NUM
eurjchem-701	56	22	min	min	NOUN
eurjchem-701	56	23	in	in	ADP
eurjchem-701	56	24	96‐well	96‐well	NUM
eurjchem-701	56	25	plates	plate	NOUN
eurjchem-701	56	26	.	.	PUNCT
eurjchem-701	57	1	the	the	DET
eurjchem-701	57	2	urease	urease	ADJ
eurjchem-701	57	3	inhibitory	inhibitory	ADJ
eurjchem-701	57	4	activity	activity	NOUN
eurjchem-701	57	5	was	be	AUX
eurjchem-701	57	6	determined	determine	VERB
eurjchem-701	57	7	by	by	ADP
eurjchem-701	57	8	determining	determine	VERB
eurjchem-701	57	9	ammonia	ammonia	ADJ
eurjchem-701	57	10	production	production	NOUN
eurjchem-701	57	11	by	by	ADP
eurjchem-701	57	12	utilizing	utilize	VERB
eurjchem-701	57	13	indophenol	indophenol	NOUN
eurjchem-701	57	14	method	method	NOUN
eurjchem-701	57	15	[	[	X
eurjchem-701	57	16	13	13	NUM
eurjchem-701	57	17	]	]	PUNCT
eurjchem-701	57	18	.	.	PUNCT
eurjchem-701	58	1	concisely	concisely	ADV
eurjchem-701	58	2	,	,	PUNCT
eurjchem-701	58	3	to	to	ADP
eurjchem-701	58	4	each	each	DET
eurjchem-701	58	5	well	well	NOUN
eurjchem-701	58	6	45	45	NUM
eurjchem-701	58	7	μl	μl	NUM
eurjchem-701	58	8	each	each	DET
eurjchem-701	58	9	phenol	phenol	ADJ
eurjchem-701	58	10	reagent	reagent	NOUN
eurjchem-701	58	11	(	(	PUNCT
eurjchem-701	58	12	1	1	NUM
eurjchem-701	58	13	%	%	NOUN
eurjchem-701	58	14	w	w	NOUN
eurjchem-701	58	15	/	/	SYM
eurjchem-701	58	16	v	v	NOUN
eurjchem-701	58	17	phenol	phenol	NOUN
eurjchem-701	58	18	and	and	CCONJ
eurjchem-701	58	19	0.005	0.005	NUM
eurjchem-701	58	20	%	%	NOUN
eurjchem-701	58	21	w	w	NOUN
eurjchem-701	58	22	/	/	SYM
eurjchem-701	58	23	v	v	NUM
eurjchem-701	58	24	sodium	sodium	NOUN
eurjchem-701	58	25	nitroprussside	nitroprussside	NOUN
eurjchem-701	58	26	)	)	PUNCT
eurjchem-701	58	27	and	and	CCONJ
eurjchem-701	58	28	70	70	NUM
eurjchem-701	58	29	μl	μl	ADP
eurjchem-701	58	30	of	of	ADP
eurjchem-701	58	31	alkali	alkali	ADJ
eurjchem-701	58	32	reagent	reagent	NOUN
eurjchem-701	58	33	(	(	PUNCT
eurjchem-701	58	34	0.5	0.5	NUM
eurjchem-701	58	35	%	%	NOUN
eurjchem-701	58	36	w	w	PROPN
eurjchem-701	58	37	/	/	SYM
eurjchem-701	58	38	v	v	NOUN
eurjchem-701	58	39	naoh	naoh	NOUN
eurjchem-701	58	40	and	and	CCONJ
eurjchem-701	58	41	0.1	0.1	NUM
eurjchem-701	58	42	%	%	NOUN
eurjchem-701	58	43	active	active	ADJ
eurjchem-701	58	44	chloride	chloride	NOUN
eurjchem-701	58	45	naocl	naocl	NOUN
eurjchem-701	58	46	)	)	PUNCT
eurjchem-701	58	47	were	be	AUX
eurjchem-701	58	48	added	add	VERB
eurjchem-701	58	49	.	.	PUNCT
eurjchem-701	59	1	hameed	hameed	PROPN
eurjchem-701	59	2	et	et	PROPN
eurjchem-701	59	3	al	al	PROPN
eurjchem-701	59	4	.	.	PUNCT
eurjchem-701	59	5	/	/	SYM
eurjchem-701	59	6	european	european	PROPN
eurjchem-701	59	7	journal	journal	PROPN
eurjchem-701	59	8	of	of	ADP
eurjchem-701	59	9	chemistry	chemistry	NOUN
eurjchem-701	59	10	4	4	NUM
eurjchem-701	59	11	(	(	PUNCT
eurjchem-701	59	12	1	1	NUM
eurjchem-701	59	13	)	)	PUNCT
eurjchem-701	59	14	(	(	PUNCT
eurjchem-701	59	15	2013	2013	NUM
eurjchem-701	59	16	)	)	PUNCT
eurjchem-701	59	17	49‐52	49‐52	NUM
eurjchem-701	59	18	51	51	NUM
eurjchem-701	60	1	the	the	DET
eurjchem-701	60	2	increasing	increase	VERB
eurjchem-701	60	3	absorbance	absorbance	NOUN
eurjchem-701	60	4	at	at	ADP
eurjchem-701	60	5	630	630	NUM
eurjchem-701	60	6	nm	nm	NOUN
eurjchem-701	60	7	was	be	AUX
eurjchem-701	60	8	measured	measure	VERB
eurjchem-701	60	9	after	after	ADP
eurjchem-701	60	10	50	50	NUM
eurjchem-701	60	11	min	min	NOUN
eurjchem-701	60	12	,	,	PUNCT
eurjchem-701	60	13	using	use	VERB
eurjchem-701	60	14	a	a	DET
eurjchem-701	60	15	microplate	microplate	NOUN
eurjchem-701	60	16	reader	reader	NOUN
eurjchem-701	60	17	(	(	PUNCT
eurjchem-701	60	18	molecular	molecular	ADJ
eurjchem-701	60	19	device	device	NOUN
eurjchem-701	60	20	,	,	PUNCT
eurjchem-701	60	21	usa	usa	PROPN
eurjchem-701	60	22	)	)	PUNCT
eurjchem-701	60	23	.	.	PUNCT
eurjchem-701	61	1	all	all	DET
eurjchem-701	61	2	the	the	DET
eurjchem-701	61	3	reactions	reaction	NOUN
eurjchem-701	61	4	were	be	AUX
eurjchem-701	61	5	performed	perform	VERB
eurjchem-701	61	6	in	in	ADP
eurjchem-701	61	7	triplicate	triplicate	NOUN
eurjchem-701	61	8	in	in	ADP
eurjchem-701	61	9	a	a	DET
eurjchem-701	61	10	final	final	ADJ
eurjchem-701	61	11	volume	volume	NOUN
eurjchem-701	61	12	of	of	ADP
eurjchem-701	61	13	200	200	NUM
eurjchem-701	61	14	μl	μl	NOUN
eurjchem-701	61	15	.	.	PUNCT
eurjchem-701	62	1	the	the	DET
eurjchem-701	62	2	results	result	NOUN
eurjchem-701	62	3	(	(	PUNCT
eurjchem-701	62	4	change	change	NOUN
eurjchem-701	62	5	in	in	ADP
eurjchem-701	62	6	absorbance	absorbance	NOUN
eurjchem-701	62	7	per	per	ADP
eurjchem-701	62	8	min	min	NOUN
eurjchem-701	62	9	)	)	PUNCT
eurjchem-701	62	10	were	be	AUX
eurjchem-701	62	11	processed	process	VERB
eurjchem-701	62	12	by	by	ADP
eurjchem-701	62	13	using	use	VERB
eurjchem-701	62	14	softmax	softmax	ADJ
eurjchem-701	62	15	pro	pro	X
eurjchem-701	62	16	software	software	NOUN
eurjchem-701	62	17	(	(	PUNCT
eurjchem-701	62	18	molecular	molecular	ADJ
eurjchem-701	62	19	device	device	NOUN
eurjchem-701	62	20	,	,	PUNCT
eurjchem-701	62	21	usa	usa	PROPN
eurjchem-701	62	22	)	)	PUNCT
eurjchem-701	62	23	.	.	PUNCT
eurjchem-701	63	1	the	the	DET
eurjchem-701	63	2	ph	ph	NOUN
eurjchem-701	63	3	was	be	AUX
eurjchem-701	63	4	maintained	maintain	VERB
eurjchem-701	63	5	6.8	6.8	NUM
eurjchem-701	63	6	in	in	ADP
eurjchem-701	63	7	all	all	DET
eurjchem-701	63	8	assays	assay	NOUN
eurjchem-701	63	9	.	.	PUNCT
eurjchem-701	64	1	percentage	percentage	NOUN
eurjchem-701	64	2	inhibitions	inhibition	NOUN
eurjchem-701	64	3	were	be	AUX
eurjchem-701	64	4	calculated	calculate	VERB
eurjchem-701	64	5	from	from	ADP
eurjchem-701	64	6	the	the	DET
eurjchem-701	64	7	formula	formula	NOUN
eurjchem-701	64	8	100‐(od	100‐(od	PROPN
eurjchem-701	64	9	test	test	VERB
eurjchem-701	65	1	well	well	ADV
eurjchem-701	65	2	/	/	SYM
eurjchem-701	65	3	od	od	PROPN
eurjchem-701	65	4	control)×100	control)×100	PROPN
eurjchem-701	65	5	.	.	PUNCT
eurjchem-701	65	6	thiourea	thiourea	NOUN
eurjchem-701	65	7	was	be	AUX
eurjchem-701	65	8	used	use	VERB
eurjchem-701	65	9	as	as	ADP
eurjchem-701	65	10	the	the	DET
eurjchem-701	65	11	standard	standard	ADJ
eurjchem-701	65	12	inhibitor	inhibitor	NOUN
eurjchem-701	65	13	of	of	ADP
eurjchem-701	65	14	urease	urease	NOUN
eurjchem-701	65	15	(	(	PUNCT
eurjchem-701	65	16	table	table	NOUN
eurjchem-701	65	17	2	2	NUM
eurjchem-701	65	18	)	)	PUNCT
eurjchem-701	65	19	.	.	PUNCT
eurjchem-701	66	1	table	table	NOUN
eurjchem-701	66	2	2	2	NUM
eurjchem-701	66	3	.	.	PUNCT
eurjchem-701	67	1	in	in	ADP
eurjchem-701	67	2	vitro	vitro	X
eurjchem-701	67	3	urease	urease	NOUN
eurjchem-701	67	4	activity	activity	NOUN
eurjchem-701	67	5	of	of	ADP
eurjchem-701	67	6	compounds	compound	NOUN
eurjchem-701	67	7	8a‐n	8a‐n	VERB
eurjchem-701	67	8	.	.	PUNCT
eurjchem-701	68	1	entry	entry	NOUN
eurjchem-701	68	2	compounds	compound	VERB
eurjchem-701	68	3	ic50	ic50	PROPN
eurjchem-701	68	4	(	(	PUNCT
eurjchem-701	68	5	μm	μm	NUM
eurjchem-701	68	6	±	±	NUM
eurjchem-701	68	7	sem	sem	NOUN
eurjchem-701	68	8	a	a	NOUN
eurjchem-701	68	9	)	)	PUNCT
eurjchem-701	68	10	1	1	NUM
eurjchem-701	68	11	8a	8a	NUM
eurjchem-701	68	12	na	na	PART
eurjchem-701	68	13	b	b	PROPN
eurjchem-701	68	14	2	2	NUM
eurjchem-701	68	15	8b	8b	NUM
eurjchem-701	68	16	na	na	PART
eurjchem-701	68	17	b	b	PROPN
eurjchem-701	68	18	3	3	NUM
eurjchem-701	68	19	8c	8c	NUM
eurjchem-701	68	20	na	na	ADP
eurjchem-701	68	21	b	b	SYM
eurjchem-701	68	22	4	4	NUM
eurjchem-701	68	23	8d	8d	NUM
eurjchem-701	68	24	na	na	NOUN
eurjchem-701	68	25	b	b	PROPN
eurjchem-701	68	26	5	5	NUM
eurjchem-701	68	27	8e	8e	NUM
eurjchem-701	68	28	na	na	NOUN
eurjchem-701	68	29	b	b	PROPN
eurjchem-701	68	30	6	6	NUM
eurjchem-701	68	31	8f	8f	NOUN
eurjchem-701	68	32	na	na	PART
eurjchem-701	68	33	b	b	SYM
eurjchem-701	68	34	7	7	NUM
eurjchem-701	68	35	8	8	NUM
eurjchem-701	68	36	g	g	PROPN
eurjchem-701	68	37	244.66	244.66	NUM
eurjchem-701	68	38	±	±	NUM
eurjchem-701	68	39	9.37	9.37	NUM
eurjchem-701	68	40	8	8	NUM
eurjchem-701	68	41	8h	8h	NUM
eurjchem-701	68	42	na	na	NOUN
eurjchem-701	68	43	b	b	PROPN
eurjchem-701	68	44	9	9	NUM
eurjchem-701	68	45	8i	8i	NUM
eurjchem-701	68	46	na	na	ADP
eurjchem-701	68	47	b	b	NUM
eurjchem-701	68	48	10	10	NUM
eurjchem-701	68	49	8j	8j	NUM
eurjchem-701	68	50	na	na	NOUN
eurjchem-701	68	51	b	b	PROPN
eurjchem-701	68	52	11	11	NUM
eurjchem-701	68	53	8k	8k	NUM
eurjchem-701	68	54	20.48	20.48	NUM
eurjchem-701	68	55	±	±	NUM
eurjchem-701	68	56	0.66	0.66	NUM
eurjchem-701	68	57	12	12	NUM
eurjchem-701	68	58	8l	8l	NOUN
eurjchem-701	68	59	84.87	84.87	NUM
eurjchem-701	68	60	±	±	NUM
eurjchem-701	68	61	6.99	6.99	NUM
eurjchem-701	68	62	13	13	NUM
eurjchem-701	68	63	8	8	NUM
eurjchem-701	68	64	m	m	NOUN
eurjchem-701	68	65	na	na	NOUN
eurjchem-701	68	66	b	b	PROPN
eurjchem-701	68	67	14	14	NUM
eurjchem-701	68	68	8n/9o	8n/9o	NUM
eurjchem-701	68	69	na	na	PROPN
eurjchem-701	68	70	b	b	NOUN
eurjchem-701	68	71	thiourea	thiourea	NOUN
eurjchem-701	68	72	c	c	PROPN
eurjchem-701	68	73	21.0	21.0	NUM
eurjchem-701	68	74	±	±	NOUN
eurjchem-701	68	75	0.01	0.01	NUM
eurjchem-701	68	76	a	a	DET
eurjchem-701	68	77	sem	sem	NOUN
eurjchem-701	68	78	is	be	AUX
eurjchem-701	68	79	the	the	DET
eurjchem-701	68	80	standard	standard	ADJ
eurjchem-701	68	81	error	error	NOUN
eurjchem-701	68	82	of	of	ADP
eurjchem-701	68	83	the	the	DET
eurjchem-701	68	84	mean	mean	NOUN
eurjchem-701	68	85	.	.	PUNCT
eurjchem-701	69	1	b	b	X
eurjchem-701	69	2	na	na	NOUN
eurjchem-701	69	3	:	:	PUNCT
eurjchem-701	69	4	not	not	PART
eurjchem-701	69	5	active	active	ADJ
eurjchem-701	69	6	.	.	PUNCT
eurjchem-701	70	1	c	c	NOUN
eurjchem-701	70	2	thiourea	thiourea	NOUN
eurjchem-701	70	3	.	.	PUNCT
eurjchem-701	71	1	2.3	2.3	NUM
eurjchem-701	71	2	.	.	PUNCT
eurjchem-701	71	3	anticancer	anticancer	NOUN
eurjchem-701	71	4	activity	activity	NOUN
eurjchem-701	71	5	assay	assay	VERB
eurjchem-701	71	6	(	(	PUNCT
eurjchem-701	71	7	in	in	ADP
eurjchem-701	71	8	vitro	vitro	X
eurjchem-701	71	9	)	)	PUNCT
eurjchem-701	71	10	the	the	DET
eurjchem-701	71	11	anticancer	anticancer	NOUN
eurjchem-701	71	12	activity	activity	NOUN
eurjchem-701	71	13	of	of	ADP
eurjchem-701	71	14	all	all	DET
eurjchem-701	71	15	the	the	DET
eurjchem-701	71	16	compounds	compound	NOUN
eurjchem-701	71	17	in	in	ADP
eurjchem-701	71	18	the	the	DET
eurjchem-701	71	19	series	series	NOUN
eurjchem-701	71	20	(	(	PUNCT
eurjchem-701	71	21	8a‐n	8a‐n	PROPN
eurjchem-701	71	22	)	)	PUNCT
eurjchem-701	71	23	was	be	AUX
eurjchem-701	71	24	estimated	estimate	VERB
eurjchem-701	71	25	in	in	ADP
eurjchem-701	71	26	96‐well	96‐well	NUM
eurjchem-701	71	27	flat‐bottomed	flat‐bottome	VERB
eurjchem-701	71	28	micro	micro	ADJ
eurjchem-701	71	29	plates	plate	NOUN
eurjchem-701	71	30	by	by	ADP
eurjchem-701	71	31	using	use	VERB
eurjchem-701	71	32	the	the	DET
eurjchem-701	71	33	standard	standard	ADJ
eurjchem-701	71	34	mtt	mtt	NOUN
eurjchem-701	71	35	(	(	PUNCT
eurjchem-701	71	36	3‐[4,5‐dimethylthiazole‐2‐yl]‐2,5‐	3‐[4,5‐dimethylthiazole‐2‐yl]‐2,5‐	NUM
eurjchem-701	71	37	diphenyl‐tetrazolium	diphenyl‐tetrazolium	NOUN
eurjchem-701	71	38	bromide	bromide	NOUN
eurjchem-701	71	39	)	)	PUNCT
eurjchem-701	71	40	colorimetric	colorimetric	ADJ
eurjchem-701	71	41	assay	assay	NOUN
eurjchem-701	71	42	[	[	X
eurjchem-701	71	43	14	14	NUM
eurjchem-701	71	44	]	]	PUNCT
eurjchem-701	71	45	.	.	PUNCT
eurjchem-701	72	1	cells	cell	NOUN
eurjchem-701	72	2	were	be	AUX
eurjchem-701	72	3	cultured	cultured	ADJ
eurjchem-701	72	4	in	in	ADP
eurjchem-701	72	5	dulbecco	dulbecco	NOUN
eurjchem-701	72	6	’s	’s	PART
eurjchem-701	72	7	modified	modify	VERB
eurjchem-701	72	8	eagle	eagle	PROPN
eurjchem-701	72	9	medium	medium	NOUN
eurjchem-701	72	10	,	,	PUNCT
eurjchem-701	72	11	supplemented	supplement	VERB
eurjchem-701	72	12	with	with	ADP
eurjchem-701	72	13	5	5	NUM
eurjchem-701	72	14	%	%	NOUN
eurjchem-701	72	15	of	of	ADP
eurjchem-701	72	16	fetal	fetal	ADJ
eurjchem-701	72	17	bovine	bovine	NOUN
eurjchem-701	72	18	serum	serum	NOUN
eurjchem-701	72	19	(	(	PUNCT
eurjchem-701	72	20	fbs	fbs	PROPN
eurjchem-701	72	21	)	)	PUNCT
eurjchem-701	72	22	,	,	PUNCT
eurjchem-701	72	23	100	100	NUM
eurjchem-701	72	24	iu	iu	ADV
eurjchem-701	72	25	/	/	SYM
eurjchem-701	72	26	ml	ml	NOUN
eurjchem-701	72	27	of	of	ADP
eurjchem-701	72	28	penicillin	penicillin	NOUN
eurjchem-701	72	29	and	and	CCONJ
eurjchem-701	72	30	100	100	NUM
eurjchem-701	72	31	µg	µg	ADJ
eurjchem-701	72	32	/	/	SYM
eurjchem-701	72	33	ml	ml	NOUN
eurjchem-701	72	34	of	of	ADP
eurjchem-701	72	35	streptomycin	streptomycin	PROPN
eurjchem-701	72	36	in	in	ADP
eurjchem-701	72	37	75	75	NUM
eurjchem-701	72	38	cm2	cm2	NOUN
eurjchem-701	72	39	flasks	flask	NOUN
eurjchem-701	72	40	,	,	PUNCT
eurjchem-701	72	41	and	and	CCONJ
eurjchem-701	72	42	kept	keep	VERB
eurjchem-701	72	43	in	in	ADP
eurjchem-701	72	44	5	5	NUM
eurjchem-701	72	45	%	%	NOUN
eurjchem-701	72	46	co2	co2	NOUN
eurjchem-701	72	47	incubator	incubator	NOUN
eurjchem-701	72	48	at	at	ADP
eurjchem-701	72	49	37	37	NUM
eurjchem-701	72	50	°	°	NOUN
eurjchem-701	72	51	c	c	NOUN
eurjchem-701	72	52	.	.	PUNCT
eurjchem-701	73	1	the	the	DET
eurjchem-701	73	2	rapidly	rapidly	ADV
eurjchem-701	73	3	growing	grow	VERB
eurjchem-701	73	4	cells	cell	NOUN
eurjchem-701	73	5	were	be	AUX
eurjchem-701	73	6	collected	collect	VERB
eurjchem-701	73	7	,	,	PUNCT
eurjchem-701	73	8	counted	count	VERB
eurjchem-701	73	9	with	with	ADP
eurjchem-701	73	10	haemocytometer	haemocytometer	NOUN
eurjchem-701	73	11	and	and	CCONJ
eurjchem-701	73	12	diluted	dilute	VERB
eurjchem-701	73	13	with	with	ADP
eurjchem-701	73	14	a	a	DET
eurjchem-701	73	15	particular	particular	ADJ
eurjchem-701	73	16	medium	medium	NOUN
eurjchem-701	73	17	.	.	PUNCT
eurjchem-701	74	1	cell	cell	NOUN
eurjchem-701	74	2	cultures	culture	NOUN
eurjchem-701	74	3	(	(	PUNCT
eurjchem-701	74	4	1x105	1x105	NUM
eurjchem-701	74	5	cells	cell	NOUN
eurjchem-701	74	6	/	/	SYM
eurjchem-701	74	7	ml	ml	NOUN
eurjchem-701	74	8	)	)	PUNCT
eurjchem-701	74	9	was	be	AUX
eurjchem-701	74	10	prepared	prepare	VERB
eurjchem-701	74	11	and	and	CCONJ
eurjchem-701	74	12	introduced	introduce	VERB
eurjchem-701	74	13	(	(	PUNCT
eurjchem-701	74	14	100	100	NUM
eurjchem-701	74	15	µl	µl	PART
eurjchem-701	74	16	/	/	SYM
eurjchem-701	74	17	well	well	NOUN
eurjchem-701	74	18	)	)	PUNCT
eurjchem-701	74	19	into	into	ADP
eurjchem-701	74	20	96‐well	96‐well	NUM
eurjchem-701	74	21	plates	plate	NOUN
eurjchem-701	74	22	.	.	PUNCT
eurjchem-701	75	1	the	the	DET
eurjchem-701	75	2	medium	medium	NOUN
eurjchem-701	75	3	was	be	AUX
eurjchem-701	75	4	removed	remove	VERB
eurjchem-701	75	5	after	after	ADP
eurjchem-701	75	6	overnight	overnight	ADJ
eurjchem-701	75	7	incubation	incubation	NOUN
eurjchem-701	75	8	and	and	CCONJ
eurjchem-701	75	9	200	200	NUM
eurjchem-701	75	10	µl	µl	NOUN
eurjchem-701	75	11	of	of	ADP
eurjchem-701	75	12	fresh	fresh	ADJ
eurjchem-701	75	13	medium	medium	NOUN
eurjchem-701	75	14	was	be	AUX
eurjchem-701	75	15	added	add	VERB
eurjchem-701	75	16	with	with	ADP
eurjchem-701	75	17	different	different	ADJ
eurjchem-701	75	18	concentrations	concentration	NOUN
eurjchem-701	75	19	of	of	ADP
eurjchem-701	75	20	compounds	compound	NOUN
eurjchem-701	75	21	(	(	PUNCT
eurjchem-701	75	22	5‐50	5‐50	NUM
eurjchem-701	75	23	µm	µm	NOUN
eurjchem-701	75	24	)	)	PUNCT
eurjchem-701	75	25	.	.	PUNCT
eurjchem-701	76	1	after	after	ADP
eurjchem-701	76	2	48	48	NUM
eurjchem-701	76	3	h	h	NOUN
eurjchem-701	76	4	,	,	PUNCT
eurjchem-701	76	5	200	200	NUM
eurjchem-701	76	6	µl	µl	ADP
eurjchem-701	76	7	mtt	mtt	NOUN
eurjchem-701	76	8	(	(	PUNCT
eurjchem-701	76	9	0.5	0.5	NUM
eurjchem-701	76	10	mg	mg	PROPN
eurjchem-701	76	11	/	/	SYM
eurjchem-701	76	12	ml	ml	NOUN
eurjchem-701	76	13	)	)	PUNCT
eurjchem-701	76	14	was	be	AUX
eurjchem-701	76	15	added	add	VERB
eurjchem-701	76	16	to	to	ADP
eurjchem-701	76	17	each	each	DET
eurjchem-701	76	18	well	well	ADV
eurjchem-701	76	19	and	and	CCONJ
eurjchem-701	76	20	incubated	incubate	VERB
eurjchem-701	76	21	further	far	ADV
eurjchem-701	76	22	for	for	ADP
eurjchem-701	76	23	4	4	NUM
eurjchem-701	76	24	h.	h.	NOUN
eurjchem-701	76	25	consequently	consequently	ADV
eurjchem-701	76	26	,	,	PUNCT
eurjchem-701	76	27	100	100	NUM
eurjchem-701	76	28	µl	µl	NOUN
eurjchem-701	76	29	of	of	ADP
eurjchem-701	76	30	dmso	dmso	NOUN
eurjchem-701	76	31	was	be	AUX
eurjchem-701	76	32	added	add	VERB
eurjchem-701	76	33	to	to	ADP
eurjchem-701	76	34	each	each	DET
eurjchem-701	76	35	well	well	ADV
eurjchem-701	76	36	.	.	PUNCT
eurjchem-701	77	1	the	the	DET
eurjchem-701	77	2	reduction	reduction	NOUN
eurjchem-701	77	3	in	in	ADP
eurjchem-701	77	4	mtt	mtt	NOUN
eurjchem-701	77	5	to	to	PART
eurjchem-701	77	6	formazan	formazan	VERB
eurjchem-701	77	7	within	within	ADP
eurjchem-701	77	8	cells	cell	NOUN
eurjchem-701	77	9	was	be	AUX
eurjchem-701	77	10	calculated	calculate	VERB
eurjchem-701	77	11	by	by	ADP
eurjchem-701	77	12	measuring	measure	VERB
eurjchem-701	77	13	the	the	DET
eurjchem-701	77	14	absorbance	absorbance	NOUN
eurjchem-701	77	15	at	at	ADP
eurjchem-701	77	16	570	570	NUM
eurjchem-701	77	17	nm	nm	NOUN
eurjchem-701	77	18	,	,	PUNCT
eurjchem-701	77	19	using	use	VERB
eurjchem-701	77	20	a	a	DET
eurjchem-701	77	21	micro	micro	ADJ
eurjchem-701	77	22	plate	plate	NOUN
eurjchem-701	77	23	reader	reader	NOUN
eurjchem-701	77	24	(	(	PUNCT
eurjchem-701	77	25	spectra	spectra	PROPN
eurjchem-701	77	26	max	max	PROPN
eurjchem-701	77	27	plus	plus	CCONJ
eurjchem-701	77	28	,	,	PUNCT
eurjchem-701	77	29	molecular	molecular	ADJ
eurjchem-701	77	30	devices	device	NOUN
eurjchem-701	77	31	,	,	PUNCT
eurjchem-701	77	32	ca	ca	PROPN
eurjchem-701	77	33	,	,	PUNCT
eurjchem-701	77	34	usa	usa	PROPN
eurjchem-701	77	35	)	)	PUNCT
eurjchem-701	77	36	.	.	PUNCT
eurjchem-701	78	1	the	the	DET
eurjchem-701	78	2	cytotoxicity	cytotoxicity	NOUN
eurjchem-701	78	3	was	be	AUX
eurjchem-701	78	4	recorded	record	VERB
eurjchem-701	78	5	as	as	ADP
eurjchem-701	78	6	concentration	concentration	NOUN
eurjchem-701	78	7	causing	cause	VERB
eurjchem-701	78	8	50	50	NUM
eurjchem-701	78	9	%	%	NOUN
eurjchem-701	78	10	growth	growth	NOUN
eurjchem-701	78	11	inhibition	inhibition	NOUN
eurjchem-701	78	12	(	(	PUNCT
eurjchem-701	78	13	ic50	ic50	PROPN
eurjchem-701	78	14	)	)	PUNCT
eurjchem-701	78	15	for	for	ADP
eurjchem-701	78	16	cell	cell	NOUN
eurjchem-701	78	17	lines	line	NOUN
eurjchem-701	78	18	.	.	PUNCT
eurjchem-701	79	1	the	the	DET
eurjchem-701	79	2	percent	percent	NOUN
eurjchem-701	79	3	inhibition	inhibition	NOUN
eurjchem-701	79	4	was	be	AUX
eurjchem-701	79	5	calculated	calculate	VERB
eurjchem-701	79	6	by	by	ADP
eurjchem-701	79	7	using	use	VERB
eurjchem-701	79	8	the	the	DET
eurjchem-701	79	9	following	follow	VERB
eurjchem-701	79	10	formula	formula	NOUN
eurjchem-701	79	11	:	:	PUNCT
eurjchem-701	79	12	%	%	NOUN
eurjchem-701	79	13	inhibition	inhibition	NOUN
eurjchem-701	79	14	=	=	SYM
eurjchem-701	79	15	100‐((mean	100‐((mean	NOUN
eurjchem-701	79	16	of	of	ADP
eurjchem-701	79	17	o.d	o.d	PROPN
eurjchem-701	79	18	of	of	ADP
eurjchem-701	79	19	test	test	NOUN
eurjchem-701	79	20	compound	compound	NOUN
eurjchem-701	79	21	–	–	PUNCT
eurjchem-701	79	22	mean	mean	NOUN
eurjchem-701	79	23	of	of	ADP
eurjchem-701	79	24	o.d	o.d	PROPN
eurjchem-701	79	25	of	of	ADP
eurjchem-701	79	26	negative	negative	ADJ
eurjchem-701	79	27	control)/	control)/	NOUN
eurjchem-701	79	28	(	(	PUNCT
eurjchem-701	79	29	mean	mean	NOUN
eurjchem-701	79	30	of	of	ADP
eurjchem-701	79	31	o.d	o.d	PROPN
eurjchem-701	79	32	of	of	ADP
eurjchem-701	79	33	positive	positive	ADJ
eurjchem-701	79	34	control‐mean	control‐mean	NOUN
eurjchem-701	79	35	of	of	ADP
eurjchem-701	79	36	o.d	o.d	PROPN
eurjchem-701	79	37	of	of	ADP
eurjchem-701	79	38	negative	negative	ADJ
eurjchem-701	79	39	control)*100	control)*100	NOUN
eurjchem-701	79	40	)	)	PUNCT
eurjchem-701	79	41	.	.	PUNCT
eurjchem-701	80	1	doxorubicin	doxorubicin	PROPN
eurjchem-701	80	2	was	be	AUX
eurjchem-701	80	3	used	use	VERB
eurjchem-701	80	4	as	as	ADP
eurjchem-701	80	5	the	the	DET
eurjchem-701	80	6	standard	standard	ADJ
eurjchem-701	80	7	anticancer	anticancer	NOUN
eurjchem-701	80	8	drugs	drug	NOUN
eurjchem-701	80	9	.	.	PUNCT
eurjchem-701	81	1	3	3	X
eurjchem-701	81	2	.	.	NOUN
eurjchem-701	81	3	results	result	NOUN
eurjchem-701	81	4	and	and	CCONJ
eurjchem-701	81	5	discussion	discussion	VERB
eurjchem-701	81	6	the	the	DET
eurjchem-701	81	7	synthesis	synthesis	NOUN
eurjchem-701	81	8	of	of	ADP
eurjchem-701	81	9	polyfunctional	polyfunctional	ADJ
eurjchem-701	81	10	5,6‐dihydropyridine	5,6‐dihydropyridine	NUM
eurjchem-701	81	11	derivatives	derivative	NOUN
eurjchem-701	81	12	8a‐n	8a‐n	NOUN
eurjchem-701	81	13	have	have	AUX
eurjchem-701	81	14	been	be	AUX
eurjchem-701	81	15	shown	show	VERB
eurjchem-701	81	16	in	in	ADP
eurjchem-701	81	17	the	the	DET
eurjchem-701	81	18	scheme	scheme	NOUN
eurjchem-701	81	19	1	1	NUM
eurjchem-701	81	20	.	.	PUNCT
eurjchem-701	82	1	the	the	DET
eurjchem-701	82	2	structure	structure	NOUN
eurjchem-701	82	3	of	of	ADP
eurjchem-701	82	4	these	these	DET
eurjchem-701	82	5	compounds	compound	NOUN
eurjchem-701	82	6	8a‐n	8a‐n	PROPN
eurjchem-701	82	7	was	be	AUX
eurjchem-701	82	8	confirmed	confirm	VERB
eurjchem-701	82	9	by	by	ADP
eurjchem-701	82	10	using	use	VERB
eurjchem-701	82	11	different	different	ADJ
eurjchem-701	82	12	spectroscopic	spectroscopic	NOUN
eurjchem-701	82	13	techniques	technique	NOUN
eurjchem-701	82	14	[	[	X
eurjchem-701	82	15	4	4	NUM
eurjchem-701	82	16	]	]	PUNCT
eurjchem-701	82	17	.	.	PUNCT
eurjchem-701	83	1	1h‐nmr	1h‐nmr	NUM
eurjchem-701	83	2	spectra	spectra	NOUN
eurjchem-701	83	3	of	of	ADP
eurjchem-701	83	4	the	the	DET
eurjchem-701	83	5	synthesized	synthesize	VERB
eurjchem-701	83	6	dimers	dimer	NOUN
eurjchem-701	83	7	8a‐n	8a‐n	PROPN
eurjchem-701	83	8	showed	show	VERB
eurjchem-701	83	9	two	two	NUM
eurjchem-701	83	10	distinctive	distinctive	ADJ
eurjchem-701	83	11	doublets	doublet	NOUN
eurjchem-701	83	12	at	at	ADP
eurjchem-701	83	13	3.49	3.49	NUM
eurjchem-701	83	14	ppm	ppm	NOUN
eurjchem-701	83	15	and	and	CCONJ
eurjchem-701	83	16	3.15	3.15	NUM
eurjchem-701	83	17	ppm	ppm	NOUN
eurjchem-701	83	18	for	for	ADP
eurjchem-701	83	19	c‐5	c‐5	NOUN
eurjchem-701	83	20	methylene	methylene	NOUN
eurjchem-701	83	21	(	(	PUNCT
eurjchem-701	83	22	‐ch2‐	‐ch2‐	PROPN
eurjchem-701	83	23	)	)	PUNCT
eurjchem-701	83	24	group	group	NOUN
eurjchem-701	83	25	protons	proton	NOUN
eurjchem-701	83	26	.	.	PUNCT
eurjchem-701	84	1	the	the	DET
eurjchem-701	84	2	proton	proton	NOUN
eurjchem-701	84	3	signals	signal	NOUN
eurjchem-701	84	4	for	for	ADP
eurjchem-701	84	5	other	other	ADJ
eurjchem-701	84	6	groups	group	NOUN
eurjchem-701	84	7	such	such	ADJ
eurjchem-701	84	8	as	as	ADP
eurjchem-701	84	9	methyl	methyl	NOUN
eurjchem-701	84	10	,	,	PUNCT
eurjchem-701	84	11	methoxy	methoxy	ADJ
eurjchem-701	84	12	and	and	CCONJ
eurjchem-701	84	13	hydroxy	hydroxy	PROPN
eurjchem-701	84	14	group	group	NOUN
eurjchem-701	84	15	of	of	ADP
eurjchem-701	84	16	new	new	ADJ
eurjchem-701	84	17	derivatives	derivative	NOUN
eurjchem-701	84	18	were	be	AUX
eurjchem-701	84	19	also	also	ADV
eurjchem-701	84	20	observed	observe	VERB
eurjchem-701	84	21	within	within	ADP
eurjchem-701	84	22	the	the	DET
eurjchem-701	84	23	range	range	NOUN
eurjchem-701	84	24	.	.	PUNCT
eurjchem-701	85	1	infrared	infrared	ADJ
eurjchem-701	85	2	spectroscopy	spectroscopy	NOUN
eurjchem-701	85	3	of	of	ADP
eurjchem-701	85	4	phenyl	phenyl	NOUN
eurjchem-701	85	5	derivative	derivative	NOUN
eurjchem-701	85	6	8a	8a	NUM
eurjchem-701	85	7	showed	show	VERB
eurjchem-701	85	8	absorption	absorption	NOUN
eurjchem-701	85	9	bands	band	NOUN
eurjchem-701	85	10	for	for	ADP
eurjchem-701	85	11	characteristic	characteristic	ADJ
eurjchem-701	85	12	nh	nh	PROPN
eurjchem-701	85	13	group	group	NOUN
eurjchem-701	85	14	at	at	ADP
eurjchem-701	85	15	3448	3448	NUM
eurjchem-701	85	16	cm‐1	cm‐1	NOUN
eurjchem-701	85	17	of	of	ADP
eurjchem-701	85	18	dihydropyridine	dihydropyridine	PROPN
eurjchem-701	85	19	ring	ring	NOUN
eurjchem-701	85	20	.	.	PUNCT
eurjchem-701	86	1	characteristic	characteristic	ADJ
eurjchem-701	86	2	absorption	absorption	NOUN
eurjchem-701	86	3	bands	band	NOUN
eurjchem-701	86	4	for	for	ADP
eurjchem-701	86	5	bromo	bromo	NOUN
eurjchem-701	86	6	,	,	PUNCT
eurjchem-701	86	7	chloro	chloro	NOUN
eurjchem-701	86	8	,	,	PUNCT
eurjchem-701	86	9	iodo	iodo	NOUN
eurjchem-701	86	10	,	,	PUNCT
eurjchem-701	86	11	methyl	methyl	NOUN
eurjchem-701	86	12	,	,	PUNCT
eurjchem-701	86	13	methoxy	methoxy	NOUN
eurjchem-701	86	14	,	,	PUNCT
eurjchem-701	86	15	hydroxyl	hydroxyl	NOUN
eurjchem-701	86	16	and	and	CCONJ
eurjchem-701	86	17	nitro	nitro	NOUN
eurjchem-701	86	18	group	group	NOUN
eurjchem-701	86	19	of	of	ADP
eurjchem-701	86	20	the	the	DET
eurjchem-701	86	21	corresponding	corresponding	ADJ
eurjchem-701	86	22	synthesized	synthesize	VERB
eurjchem-701	86	23	compounds	compound	NOUN
eurjchem-701	86	24	8a‐n	8a‐n	PROPN
eurjchem-701	86	25	were	be	AUX
eurjchem-701	86	26	observed	observe	VERB
eurjchem-701	86	27	on	on	ADP
eurjchem-701	86	28	infrared	infrared	ADJ
eurjchem-701	86	29	spectrum	spectrum	NOUN
eurjchem-701	86	30	.	.	PUNCT
eurjchem-701	87	1	all	all	DET
eurjchem-701	87	2	synthetic	synthetic	ADJ
eurjchem-701	87	3	polyfunctional	polyfunctional	ADJ
eurjchem-701	87	4	5,6‐dihydropyridine	5,6‐dihydropyridine	NUM
eurjchem-701	87	5	derivatives	derivative	NOUN
eurjchem-701	87	6	8a‐n	8a‐n	NOUN
eurjchem-701	87	7	(	(	PUNCT
eurjchem-701	87	8	table	table	NOUN
eurjchem-701	87	9	1	1	NUM
eurjchem-701	87	10	)	)	PUNCT
eurjchem-701	87	11	were	be	AUX
eurjchem-701	87	12	screened	screen	VERB
eurjchem-701	87	13	for	for	ADP
eurjchem-701	87	14	their	their	PRON
eurjchem-701	87	15	urease	urease	ADJ
eurjchem-701	87	16	inhibitory	inhibitory	ADJ
eurjchem-701	87	17	potential	potential	NOUN
eurjchem-701	87	18	[	[	X
eurjchem-701	87	19	12	12	NUM
eurjchem-701	87	20	]	]	PUNCT
eurjchem-701	87	21	(	(	PUNCT
eurjchem-701	87	22	table	table	NOUN
eurjchem-701	87	23	2	2	NUM
eurjchem-701	87	24	)	)	PUNCT
eurjchem-701	87	25	and	and	CCONJ
eurjchem-701	87	26	anticancer	anticancer	NOUN
eurjchem-701	87	27	activity	activity	NOUN
eurjchem-701	87	28	against	against	ADP
eurjchem-701	87	29	prostate	prostate	NOUN
eurjchem-701	87	30	cancer	cancer	NOUN
eurjchem-701	87	31	(	(	PUNCT
eurjchem-701	87	32	pc3	pc3	PROPN
eurjchem-701	87	33	)	)	PUNCT
eurjchem-701	87	34	and	and	CCONJ
eurjchem-701	87	35	hela	hela	PROPN
eurjchem-701	87	36	cell	cell	NOUN
eurjchem-701	87	37	lines	line	NOUN
eurjchem-701	87	38	according	accord	VERB
eurjchem-701	87	39	to	to	ADP
eurjchem-701	87	40	literature	literature	NOUN
eurjchem-701	87	41	protocol	protocol	NOUN
eurjchem-701	87	42	[	[	X
eurjchem-701	87	43	14	14	NUM
eurjchem-701	87	44	]	]	X
eurjchem-701	87	45	(	(	PUNCT
eurjchem-701	87	46	table	table	NOUN
eurjchem-701	87	47	3	3	NUM
eurjchem-701	87	48	)	)	PUNCT
eurjchem-701	87	49	.	.	PUNCT
eurjchem-701	88	1	the	the	DET
eurjchem-701	88	2	urease	urease	NOUN
eurjchem-701	88	3	inhibitory	inhibitory	ADJ
eurjchem-701	88	4	analysis	analysis	NOUN
eurjchem-701	88	5	showed	show	VERB
eurjchem-701	88	6	that	that	SCONJ
eurjchem-701	88	7	most	most	ADJ
eurjchem-701	88	8	of	of	ADP
eurjchem-701	88	9	the	the	DET
eurjchem-701	88	10	dihydropyridine	dihydropyridine	NOUN
eurjchem-701	88	11	derivatives	derivative	NOUN
eurjchem-701	88	12	are	be	AUX
eurjchem-701	88	13	inactive	inactive	ADJ
eurjchem-701	88	14	in	in	ADP
eurjchem-701	88	15	the	the	DET
eurjchem-701	88	16	series	series	NOUN
eurjchem-701	88	17	.	.	PUNCT
eurjchem-701	89	1	however	however	ADV
eurjchem-701	89	2	,	,	PUNCT
eurjchem-701	89	3	the	the	DET
eurjchem-701	89	4	compound	compound	NOUN
eurjchem-701	89	5	8k	8k	PROPN
eurjchem-701	89	6	(	(	PUNCT
eurjchem-701	89	7	ic50	ic50	PROPN
eurjchem-701	89	8	=	=	PROPN
eurjchem-701	89	9	20.4	20.4	NUM
eurjchem-701	89	10	±	±	NUM
eurjchem-701	89	11	0.66	0.66	NUM
eurjchem-701	89	12	µm	µm	NOUN
eurjchem-701	89	13	)	)	PUNCT
eurjchem-701	89	14	showed	show	VERB
eurjchem-701	89	15	comparable	comparable	ADJ
eurjchem-701	89	16	urease	urease	NOUN
eurjchem-701	89	17	inhibitory	inhibitory	ADJ
eurjchem-701	89	18	potential	potential	NOUN
eurjchem-701	89	19	,	,	PUNCT
eurjchem-701	89	20	while	while	SCONJ
eurjchem-701	89	21	compounds	compound	VERB
eurjchem-701	89	22	8l	8l	NOUN
eurjchem-701	89	23	(	(	PUNCT
eurjchem-701	89	24	ic50	ic50	PROPN
eurjchem-701	89	25	=	=	PROPN
eurjchem-701	89	26	84.8	84.8	NUM
eurjchem-701	89	27	±	±	NUM
eurjchem-701	89	28	6.99	6.99	NUM
eurjchem-701	89	29	µm	µm	NOUN
eurjchem-701	89	30	)	)	PUNCT
eurjchem-701	89	31	,	,	PUNCT
eurjchem-701	89	32	demonstrated	demonstrate	VERB
eurjchem-701	89	33	moderate	moderate	ADJ
eurjchem-701	89	34	and	and	CCONJ
eurjchem-701	89	35	compounds	compound	VERB
eurjchem-701	89	36	8	8	NUM
eurjchem-701	89	37	g	g	NOUN
eurjchem-701	89	38	(	(	PUNCT
eurjchem-701	89	39	ic50	ic50	PROPN
eurjchem-701	89	40	=	=	PROPN
eurjchem-701	89	41	244.6	244.6	NUM
eurjchem-701	89	42	±	±	NUM
eurjchem-701	89	43	9.37	9.37	NUM
eurjchem-701	89	44	µm	µm	NOUN
eurjchem-701	89	45	)	)	PUNCT
eurjchem-701	89	46	weak	weak	ADJ
eurjchem-701	89	47	inhibition	inhibition	NOUN
eurjchem-701	89	48	potential	potential	NOUN
eurjchem-701	89	49	respectively	respectively	ADV
eurjchem-701	89	50	.	.	PUNCT
eurjchem-701	89	51	table	table	NOUN
eurjchem-701	89	52	3	3	NUM
eurjchem-701	89	53	.	.	PUNCT
eurjchem-701	90	1	in	in	ADP
eurjchem-701	90	2	vitro	vitro	X
eurjchem-701	90	3	anticancer	anticancer	NOUN
eurjchem-701	90	4	activity	activity	NOUN
eurjchem-701	90	5	of	of	ADP
eurjchem-701	90	6	compounds	compound	NOUN
eurjchem-701	90	7	8a‐n	8a‐n	VERB
eurjchem-701	90	8	against	against	ADP
eurjchem-701	90	9	pc3	pc3	PROPN
eurjchem-701	90	10	and	and	CCONJ
eurjchem-701	90	11	hela	hela	PROPN
eurjchem-701	90	12	cell	cell	NOUN
eurjchem-701	90	13	lines	line	NOUN
eurjchem-701	90	14	.	.	PUNCT
eurjchem-701	91	1	entry	entry	NOUN
eurjchem-701	91	2	compounds	compound	VERB
eurjchem-701	91	3	pc3	pc3	PROPN
eurjchem-701	91	4	cell	cell	NOUN
eurjchem-701	91	5	line	line	NOUN
eurjchem-701	91	6	hela	hela	PROPN
eurjchem-701	91	7	cell	cell	NOUN
eurjchem-701	91	8	line	line	NOUN
eurjchem-701	91	9	ic50	ic50	PROPN
eurjchem-701	91	10	(	(	PUNCT
eurjchem-701	91	11	μm	μm	NUM
eurjchem-701	91	12	±	±	NUM
eurjchem-701	91	13	sem	sem	NOUN
eurjchem-701	91	14	a	a	NOUN
eurjchem-701	91	15	)	)	PUNCT
eurjchem-701	91	16	ic50	ic50	PROPN
eurjchem-701	91	17	(	(	PUNCT
eurjchem-701	91	18	μm	μm	NUM
eurjchem-701	91	19	±	±	NUM
eurjchem-701	91	20	sem	sem	NOUN
eurjchem-701	91	21	a	a	NOUN
eurjchem-701	91	22	)	)	PUNCT
eurjchem-701	91	23	1	1	NUM
eurjchem-701	91	24	8a	8a	NUM
eurjchem-701	91	25	4.40	4.40	NUM
eurjchem-701	91	26	±	±	NUM
eurjchem-701	91	27	0.13	0.13	NUM
eurjchem-701	91	28	8.81	8.81	NUM
eurjchem-701	91	29	±	±	NUM
eurjchem-701	91	30	0.25	0.25	NUM
eurjchem-701	91	31	2	2	NUM
eurjchem-701	91	32	8b	8b	NUM
eurjchem-701	91	33	6.85	6.85	NUM
eurjchem-701	91	34	±	±	NUM
eurjchem-701	91	35	0.34	0.34	NUM
eurjchem-701	91	36	8.81	8.81	NUM
eurjchem-701	91	37	±	±	NUM
eurjchem-701	91	38	0.63	0.63	NUM
eurjchem-701	91	39	3	3	NUM
eurjchem-701	91	40	8c	8c	NUM
eurjchem-701	91	41	8.03	8.03	NUM
eurjchem-701	91	42	±	±	NUM
eurjchem-701	91	43	0.22	0.22	NUM
eurjchem-701	91	44	23.06	23.06	NUM
eurjchem-701	91	45	±	±	NUM
eurjchem-701	91	46	0.10	0.10	NUM
eurjchem-701	91	47	4	4	NUM
eurjchem-701	91	48	8d	8d	NUM
eurjchem-701	91	49	8.36	8.36	NUM
eurjchem-701	91	50	±	±	NUM
eurjchem-701	91	51	0.48	0.48	NUM
eurjchem-701	91	52	14.67	14.67	NUM
eurjchem-701	91	53	±	±	NUM
eurjchem-701	91	54	0.75	0.75	NUM
eurjchem-701	91	55	5	5	NUM
eurjchem-701	91	56	8e	8e	NUM
eurjchem-701	91	57	8.87	8.87	NUM
eurjchem-701	91	58	±	±	NUM
eurjchem-701	91	59	0.59	0.59	NUM
eurjchem-701	91	60	9.67	9.67	NUM
eurjchem-701	91	61	±	±	NUM
eurjchem-701	91	62	0.20	0.20	NUM
eurjchem-701	91	63	6	6	NUM
eurjchem-701	91	64	8f	8f	NOUN
eurjchem-701	91	65	9.62	9.62	NUM
eurjchem-701	91	66	±	±	NUM
eurjchem-701	91	67	0.55	0.55	NUM
eurjchem-701	91	68	11.26	11.26	NUM
eurjchem-701	91	69	±	±	NUM
eurjchem-701	91	70	0.85	0.85	NUM
eurjchem-701	91	71	7	7	NUM
eurjchem-701	91	72	8	8	NUM
eurjchem-701	91	73	g	g	ADP
eurjchem-701	91	74	10.48	10.48	NUM
eurjchem-701	91	75	±	±	NUM
eurjchem-701	91	76	0.24	0.24	NUM
eurjchem-701	91	77	18.84	18.84	NUM
eurjchem-701	91	78	±	±	NUM
eurjchem-701	91	79	0.87	0.87	NUM
eurjchem-701	91	80	8	8	NUM
eurjchem-701	91	81	8h	8h	NUM
eurjchem-701	91	82	11.51	11.51	NUM
eurjchem-701	91	83	±	±	NUM
eurjchem-701	91	84	0.45	0.45	NUM
eurjchem-701	91	85	20.18	20.18	NUM
eurjchem-701	91	86	±	±	NUM
eurjchem-701	91	87	0.39	0.39	NUM
eurjchem-701	91	88	9	9	NUM
eurjchem-701	91	89	8i	8i	NUM
eurjchem-701	91	90	13.10	13.10	NUM
eurjchem-701	91	91	±	±	NUM
eurjchem-701	91	92	0.62	0.62	NUM
eurjchem-701	91	93	23.09	23.09	NUM
eurjchem-701	91	94	±	±	NUM
eurjchem-701	91	95	0.03	0.03	NUM
eurjchem-701	91	96	10	10	NUM
eurjchem-701	91	97	8j	8j	NUM
eurjchem-701	91	98	14.02	14.02	NUM
eurjchem-701	91	99	±	±	NUM
eurjchem-701	91	100	0.42	0.42	NUM
eurjchem-701	91	101	26.41	26.41	NUM
eurjchem-701	91	102	±	±	NUM
eurjchem-701	91	103	1.97	1.97	NUM
eurjchem-701	91	104	11	11	NUM
eurjchem-701	91	105	8k	8k	NUM
eurjchem-701	91	106	14.55	14.55	NUM
eurjchem-701	91	107	±	±	NUM
eurjchem-701	91	108	0.38	0.38	NUM
eurjchem-701	91	109	14.73	14.73	NUM
eurjchem-701	91	110	±	±	NUM
eurjchem-701	91	111	0.14	0.14	NUM
eurjchem-701	91	112	12	12	NUM
eurjchem-701	91	113	8l	8l	NOUN
eurjchem-701	91	114	>	>	X
eurjchem-701	91	115	30	30	NUM
eurjchem-701	91	116	>	>	SYM
eurjchem-701	91	117	30	30	NUM
eurjchem-701	91	118	13	13	NUM
eurjchem-701	91	119	8	8	NUM
eurjchem-701	91	120	m	m	NOUN
eurjchem-701	91	121	>	>	X
eurjchem-701	91	122	30	30	NUM
eurjchem-701	91	123	>	>	SYM
eurjchem-701	91	124	30	30	NUM
eurjchem-701	91	125	14	14	NUM
eurjchem-701	91	126	8n/9o	8n/9o	NUM
eurjchem-701	91	127	>	>	SYM
eurjchem-701	91	128	30	30	NUM
eurjchem-701	91	129	>	>	SYM
eurjchem-701	91	130	30	30	NUM
eurjchem-701	91	131	doxorubicin	doxorubicin	PROPN
eurjchem-701	91	132	b	b	PROPN
eurjchem-701	91	133	‐	‐	ADV
eurjchem-701	91	134	0.91	0.91	NUM
eurjchem-701	91	135	±	±	NUM
eurjchem-701	91	136	0.12	0.12	NUM
eurjchem-701	91	137	3.1	3.1	NUM
eurjchem-701	91	138	±	±	NOUN
eurjchem-701	91	139	0.20	0.20	NUM
eurjchem-701	91	140	a	a	DET
eurjchem-701	91	141	sem	sem	NOUN
eurjchem-701	91	142	is	be	AUX
eurjchem-701	91	143	the	the	DET
eurjchem-701	91	144	standard	standard	ADJ
eurjchem-701	91	145	error	error	NOUN
eurjchem-701	91	146	of	of	ADP
eurjchem-701	91	147	the	the	DET
eurjchem-701	91	148	mean	mean	NOUN
eurjchem-701	91	149	.	.	PUNCT
eurjchem-701	92	1	b	b	PROPN
eurjchem-701	92	2	doxorubicin	doxorubicin	PROPN
eurjchem-701	92	3	standard	standard	ADJ
eurjchem-701	92	4	anticancer	anticancer	NOUN
eurjchem-701	92	5	drug	drug	NOUN
eurjchem-701	92	6	for	for	ADP
eurjchem-701	92	7	many	many	ADJ
eurjchem-701	92	8	type	type	NOUN
eurjchem-701	92	9	of	of	ADP
eurjchem-701	92	10	cancer	cancer	NOUN
eurjchem-701	92	11	cell	cell	NOUN
eurjchem-701	92	12	lines	line	NOUN
eurjchem-701	92	13	.	.	PUNCT
eurjchem-701	93	1	compound	compound	NOUN
eurjchem-701	93	2	8k	8k	PROPN
eurjchem-701	93	3	(	(	PUNCT
eurjchem-701	93	4	4,6‐dimethoxy‐5,6‐dihydropyridine	4,6‐dimethoxy‐5,6‐dihydropyridine	PROPN
eurjchem-701	93	5	derivative	derivative	NOUN
eurjchem-701	93	6	)	)	PUNCT
eurjchem-701	93	7	demonstrated	demonstrate	VERB
eurjchem-701	93	8	excellent	excellent	ADJ
eurjchem-701	93	9	inhibitory	inhibitory	ADJ
eurjchem-701	93	10	potential	potential	NOUN
eurjchem-701	93	11	among	among	ADP
eurjchem-701	93	12	the	the	DET
eurjchem-701	93	13	series	series	NOUN
eurjchem-701	93	14	with	with	ADP
eurjchem-701	93	15	ic50	ic50	PROPN
eurjchem-701	93	16	values	value	VERB
eurjchem-701	93	17	20.4	20.4	NUM
eurjchem-701	93	18	±	±	NUM
eurjchem-701	93	19	0.66	0.66	NUM
eurjchem-701	93	20	.	.	PUNCT
eurjchem-701	94	1	while	while	SCONJ
eurjchem-701	94	2	compound	compound	NOUN
eurjchem-701	94	3	8l	8l	NOUN
eurjchem-701	94	4	(	(	PUNCT
eurjchem-701	94	5	4,6‐dihydoxy‐5,6‐dihydropyridine	4,6‐dihydoxy‐5,6‐dihydropyridine	NOUN
eurjchem-701	94	6	derivative	derivative	NOUN
eurjchem-701	94	7	)	)	PUNCT
eurjchem-701	94	8	having	have	VERB
eurjchem-701	94	9	an	an	DET
eurjchem-701	94	10	ic50	ic50	PROPN
eurjchem-701	94	11	value	value	NOUN
eurjchem-701	94	12	84.8	84.8	NUM
eurjchem-701	94	13	±	±	NUM
eurjchem-701	94	14	6.99	6.99	NUM
eurjchem-701	94	15	µm	µm	NUM
eurjchem-701	94	16	showed	show	VERB
eurjchem-701	94	17	moderate	moderate	ADJ
eurjchem-701	94	18	activity	activity	NOUN
eurjchem-701	94	19	.	.	PUNCT
eurjchem-701	95	1	the	the	DET
eurjchem-701	95	2	activity	activity	NOUN
eurjchem-701	95	3	difference	difference	NOUN
eurjchem-701	95	4	between	between	ADP
eurjchem-701	95	5	these	these	DET
eurjchem-701	95	6	analogs	analog	NOUN
eurjchem-701	95	7	suggests	suggest	VERB
eurjchem-701	95	8	that	that	SCONJ
eurjchem-701	95	9	the	the	DET
eurjchem-701	95	10	electronic	electronic	ADJ
eurjchem-701	95	11	effects	effect	NOUN
eurjchem-701	95	12	and	and	CCONJ
eurjchem-701	95	13	substituents	substituent	NOUN
eurjchem-701	95	14	position	position	NOUN
eurjchem-701	95	15	on	on	ADP
eurjchem-701	95	16	phenyl	phenyl	NOUN
eurjchem-701	95	17	rings	ring	NOUN
eurjchem-701	95	18	affect	affect	VERB
eurjchem-701	95	19	the	the	DET
eurjchem-701	95	20	urease	urease	ADJ
eurjchem-701	95	21	inhibitory	inhibitory	ADJ
eurjchem-701	95	22	activity	activity	NOUN
eurjchem-701	95	23	.	.	PUNCT
eurjchem-701	96	1	the	the	DET
eurjchem-701	96	2	4,6‐dimethyl‐5,6‐dihydro‐	4,6‐dimethyl‐5,6‐dihydro‐	NUM
eurjchem-701	96	3	pyridine	pyridine	NOUN
eurjchem-701	96	4	derivative	derivative	ADJ
eurjchem-701	96	5	8	8	NUM
eurjchem-701	96	6	g	g	NOUN
eurjchem-701	96	7	with	with	ADP
eurjchem-701	96	8	also	also	ADV
eurjchem-701	96	9	ic50	ic50	PROPN
eurjchem-701	96	10	value	value	NOUN
eurjchem-701	96	11	244.66	244.66	NUM
eurjchem-701	96	12	±	±	NOUN
eurjchem-701	96	13	0.01	0.01	NUM
eurjchem-701	96	14	µm	µm	ADP
eurjchem-701	96	15	exhibit	exhibit	NOUN
eurjchem-701	96	16	week	week	NOUN
eurjchem-701	96	17	inhibition	inhibition	NOUN
eurjchem-701	96	18	due	due	ADJ
eurjchem-701	96	19	to	to	ADP
eurjchem-701	96	20	electron	electron	VERB
eurjchem-701	96	21	denoting	denote	VERB
eurjchem-701	96	22	effects	effect	NOUN
eurjchem-701	96	23	.	.	PUNCT
eurjchem-701	97	1	in	in	ADP
eurjchem-701	97	2	this	this	DET
eurjchem-701	97	3	series	series	NOUN
eurjchem-701	97	4	,	,	PUNCT
eurjchem-701	97	5	it	it	PRON
eurjchem-701	97	6	has	have	AUX
eurjchem-701	97	7	been	be	AUX
eurjchem-701	97	8	observed	observe	VERB
eurjchem-701	97	9	that	that	SCONJ
eurjchem-701	97	10	most	most	ADJ
eurjchem-701	97	11	of	of	ADP
eurjchem-701	97	12	the	the	DET
eurjchem-701	97	13	compounds	compound	NOUN
eurjchem-701	97	14	are	be	AUX
eurjchem-701	97	15	inactive	inactive	ADJ
eurjchem-701	97	16	due	due	ADP
eurjchem-701	97	17	to	to	ADP
eurjchem-701	97	18	electron	electron	NOUN
eurjchem-701	97	19	withdrawing	withdraw	VERB
eurjchem-701	97	20	effect	effect	NOUN
eurjchem-701	97	21	of	of	ADP
eurjchem-701	97	22	substituents	substituent	NOUN
eurjchem-701	97	23	and	and	CCONJ
eurjchem-701	97	24	position	position	NOUN
eurjchem-701	97	25	of	of	ADP
eurjchem-701	97	26	electron	electron	NOUN
eurjchem-701	97	27	denoting	denote	VERB
eurjchem-701	97	28	groups	group	NOUN
eurjchem-701	97	29	in	in	ADP
eurjchem-701	97	30	the	the	DET
eurjchem-701	97	31	series	series	NOUN
eurjchem-701	97	32	8a‐n	8a‐n	PROPN
eurjchem-701	97	33	.	.	PUNCT
eurjchem-701	98	1	thus	thus	ADV
eurjchem-701	98	2	,	,	PUNCT
eurjchem-701	98	3	it	it	PRON
eurjchem-701	98	4	has	have	AUX
eurjchem-701	98	5	been	be	AUX
eurjchem-701	98	6	concluded	conclude	VERB
eurjchem-701	98	7	that	that	SCONJ
eurjchem-701	98	8	position	position	NOUN
eurjchem-701	98	9	and	and	CCONJ
eurjchem-701	98	10	electronic	electronic	ADJ
eurjchem-701	98	11	effects	effect	NOUN
eurjchem-701	98	12	of	of	ADP
eurjchem-701	98	13	functional	functional	ADJ
eurjchem-701	98	14	group	group	NOUN
eurjchem-701	98	15	on	on	ADP
eurjchem-701	98	16	phenyl	phenyl	NOUN
eurjchem-701	98	17	ring	ring	NOUN
eurjchem-701	98	18	significantly	significantly	ADV
eurjchem-701	98	19	affect	affect	VERB
eurjchem-701	98	20	the	the	DET
eurjchem-701	98	21	urease	urease	ADJ
eurjchem-701	98	22	inhibitory	inhibitory	ADJ
eurjchem-701	98	23	activity	activity	NOUN
eurjchem-701	98	24	.	.	PUNCT
eurjchem-701	99	1	this	this	DET
eurjchem-701	99	2	study	study	NOUN
eurjchem-701	99	3	identifies	identify	VERB
eurjchem-701	99	4	compound	compound	NOUN
eurjchem-701	99	5	8k	8k	PROPN
eurjchem-701	99	6	as	as	SCONJ
eurjchem-701	99	7	lead	lead	NOUN
eurjchem-701	99	8	compound	compound	NOUN
eurjchem-701	99	9	for	for	ADP
eurjchem-701	99	10	further	further	ADJ
eurjchem-701	99	11	development	development	NOUN
eurjchem-701	99	12	.	.	PUNCT
eurjchem-701	100	1	we	we	PRON
eurjchem-701	100	2	have	have	AUX
eurjchem-701	100	3	also	also	ADV
eurjchem-701	100	4	explored	explore	VERB
eurjchem-701	100	5	our	our	PRON
eurjchem-701	100	6	dihydropyridine	dihydropyridine	NOUN
eurjchem-701	100	7	series	series	NOUN
eurjchem-701	100	8	(	(	PUNCT
eurjchem-701	100	9	8a‐n	8a‐n	PROPN
eurjchem-701	100	10	)	)	PUNCT
eurjchem-701	100	11	against	against	ADP
eurjchem-701	100	12	prostate	prostate	NOUN
eurjchem-701	100	13	cancer	cancer	NOUN
eurjchem-701	100	14	cell	cell	NOUN
eurjchem-701	100	15	line	line	NOUN
eurjchem-701	100	16	and	and	CCONJ
eurjchem-701	100	17	hela	hela	ADJ
eurjchem-701	100	18	cell	cell	NOUN
eurjchem-701	100	19	line	line	NOUN
eurjchem-701	100	20	.	.	PUNCT
eurjchem-701	101	1	the	the	DET
eurjchem-701	101	2	anticancer	anticancer	NOUN
eurjchem-701	101	3	activity	activity	NOUN
eurjchem-701	101	4	results	result	VERB
eurjchem-701	101	5	on	on	ADP
eurjchem-701	101	6	both	both	DET
eurjchem-701	101	7	cell	cell	NOUN
eurjchem-701	101	8	lines	line	NOUN
eurjchem-701	101	9	showed	show	VERB
eurjchem-701	101	10	that	that	SCONJ
eurjchem-701	101	11	most	most	ADJ
eurjchem-701	101	12	of	of	ADP
eurjchem-701	101	13	the	the	DET
eurjchem-701	101	14	compounds	compound	NOUN
eurjchem-701	101	15	8a‐n	8a‐n	PROPN
eurjchem-701	101	16	are	be	AUX
eurjchem-701	101	17	active	active	ADJ
eurjchem-701	101	18	and	and	CCONJ
eurjchem-701	101	19	have	have	VERB
eurjchem-701	101	20	a	a	DET
eurjchem-701	101	21	varying	vary	VERB
eurjchem-701	101	22	degree	degree	NOUN
eurjchem-701	101	23	of	of	ADP
eurjchem-701	101	24	anticancer	anticancer	NOUN
eurjchem-701	101	25	potential	potential	NOUN
eurjchem-701	101	26	having	have	VERB
eurjchem-701	101	27	ic50	ic50	PROPN
eurjchem-701	101	28	values	value	NOUN
eurjchem-701	101	29	ranging	range	VERB
eurjchem-701	101	30	between	between	ADP
eurjchem-701	101	31	4.40	4.40	NUM
eurjchem-701	101	32	±	±	NUM
eurjchem-701	101	33	0.12	0.12	NUM
eurjchem-701	101	34	and	and	CCONJ
eurjchem-701	101	35	8.80	8.80	NUM
eurjchem-701	101	36	±	±	NUM
eurjchem-701	101	37	0.25	0.25	NUM
eurjchem-701	101	38	to	to	ADP
eurjchem-701	101	39	>	>	X
eurjchem-701	101	40	30	30	NUM
eurjchem-701	101	41	µm	µm	NUM
eurjchem-701	101	42	,	,	PUNCT
eurjchem-701	101	43	if	if	SCONJ
eurjchem-701	101	44	compared	compare	VERB
eurjchem-701	101	45	with	with	ADP
eurjchem-701	101	46	standard	standard	ADJ
eurjchem-701	101	47	doxorubicin	doxorubicin	PROPN
eurjchem-701	101	48	(	(	PUNCT
eurjchem-701	101	49	ic50	ic50	PROPN
eurjchem-701	101	50	value	value	NOUN
eurjchem-701	101	51	0.91	0.91	NUM
eurjchem-701	101	52	±	±	NUM
eurjchem-701	101	53	0.12	0.12	NUM
eurjchem-701	101	54	and	and	CCONJ
eurjchem-701	101	55	3.1	3.1	NUM
eurjchem-701	101	56	±	±	NUM
eurjchem-701	101	57	0.20	0.20	NUM
eurjchem-701	101	58	µm	µm	NOUN
eurjchem-701	101	59	)	)	PUNCT
eurjchem-701	101	60	.	.	PUNCT
eurjchem-701	102	1	compounds	compound	VERB
eurjchem-701	102	2	8a	8a	NUM
eurjchem-701	102	3	(	(	PUNCT
eurjchem-701	102	4	ic50	ic50	PROPN
eurjchem-701	102	5	=	=	PROPN
eurjchem-701	102	6	4.40	4.40	NUM
eurjchem-701	102	7	±	±	NUM
eurjchem-701	102	8	0.13	0.13	NUM
eurjchem-701	102	9	and	and	CCONJ
eurjchem-701	102	10	8.80	8.80	NUM
eurjchem-701	102	11	±	±	NUM
eurjchem-701	102	12	0.25	0.25	NUM
eurjchem-701	102	13	µm	µm	NOUN
eurjchem-701	102	14	)	)	PUNCT
eurjchem-701	102	15	,	,	PUNCT
eurjchem-701	102	16	8b	8b	NUM
eurjchem-701	102	17	(	(	PUNCT
eurjchem-701	102	18	ic50	ic50	PROPN
eurjchem-701	102	19	=	=	PROPN
eurjchem-701	102	20	6.85	6.85	NUM
eurjchem-701	102	21	±	±	NUM
eurjchem-701	102	22	0.34	0.34	NUM
eurjchem-701	102	23	and	and	CCONJ
eurjchem-701	102	24	8.81	8.81	NUM
eurjchem-701	102	25	±	±	NUM
eurjchem-701	102	26	0.63	0.63	NUM
eurjchem-701	102	27	µm	µm	NOUN
eurjchem-701	102	28	)	)	PUNCT
eurjchem-701	102	29	showed	show	VERB
eurjchem-701	102	30	highest	high	ADJ
eurjchem-701	102	31	cytoxicity	cytoxicity	NOUN
eurjchem-701	102	32	among	among	ADP
eurjchem-701	102	33	the	the	DET
eurjchem-701	102	34	series	series	NOUN
eurjchem-701	102	35	in	in	ADP
eurjchem-701	102	36	both	both	DET
eurjchem-701	102	37	cell	cell	NOUN
eurjchem-701	102	38	lines	line	NOUN
eurjchem-701	102	39	as	as	SCONJ
eurjchem-701	102	40	compared	compare	VERB
eurjchem-701	102	41	to	to	ADP
eurjchem-701	102	42	doxorubicin	doxorubicin	PROPN
eurjchem-701	102	43	.	.	PUNCT
eurjchem-701	103	1	the	the	DET
eurjchem-701	103	2	compounds	compound	NOUN
eurjchem-701	103	3	8c	8c	NOUN
eurjchem-701	103	4	(	(	PUNCT
eurjchem-701	103	5	ic50	ic50	PROPN
eurjchem-701	103	6	=	=	PROPN
eurjchem-701	103	7	8.03	8.03	NUM
eurjchem-701	103	8	±	±	NUM
eurjchem-701	103	9	0.22	0.22	NUM
eurjchem-701	103	10	µm	µm	NOUN
eurjchem-701	103	11	)	)	PUNCT
eurjchem-701	103	12	,	,	PUNCT
eurjchem-701	103	13	8d	8d	NUM
eurjchem-701	103	14	(	(	PUNCT
eurjchem-701	103	15	ic50	ic50	PROPN
eurjchem-701	103	16	=	=	PROPN
eurjchem-701	103	17	8.36	8.36	NUM
eurjchem-701	103	18	±	±	NUM
eurjchem-701	103	19	0.48	0.48	NUM
eurjchem-701	103	20	µm	µm	NOUN
eurjchem-701	103	21	)	)	PUNCT
eurjchem-701	103	22	,	,	PUNCT
eurjchem-701	103	23	8e	8e	NUM
eurjchem-701	103	24	(	(	PUNCT
eurjchem-701	103	25	ic50	ic50	PROPN
eurjchem-701	103	26	=	=	PROPN
eurjchem-701	103	27	8.87	8.87	NUM
eurjchem-701	103	28	±	±	NUM
eurjchem-701	103	29	0.59	0.59	NUM
eurjchem-701	103	30	µm	µm	NOUN
eurjchem-701	103	31	)	)	PUNCT
eurjchem-701	103	32	,	,	PUNCT
eurjchem-701	103	33	8f	8f	NOUN
eurjchem-701	103	34	(	(	PUNCT
eurjchem-701	103	35	ic50	ic50	PROPN
eurjchem-701	103	36	=	=	PROPN
eurjchem-701	103	37	9.62	9.62	NUM
eurjchem-701	103	38	±	±	NUM
eurjchem-701	103	39	0.55	0.55	NUM
eurjchem-701	103	40	µm	µm	NOUN
eurjchem-701	103	41	)	)	PUNCT
eurjchem-701	103	42	and	and	CCONJ
eurjchem-701	103	43	8	8	NUM
eurjchem-701	103	44	g	g	NOUN
eurjchem-701	103	45	(	(	PUNCT
eurjchem-701	103	46	ic50	ic50	PROPN
eurjchem-701	103	47	=	=	PROPN
eurjchem-701	103	48	10.48	10.48	NUM
eurjchem-701	103	49	±	±	NUM
eurjchem-701	103	50	0.240	0.240	NUM
eurjchem-701	103	51	µm	µm	NOUN
eurjchem-701	103	52	)	)	PUNCT
eurjchem-701	103	53	,	,	PUNCT
eurjchem-701	103	54	8h	8h	PROPN
eurjchem-701	103	55	(	(	PUNCT
eurjchem-701	103	56	ic50	ic50	PROPN
eurjchem-701	103	57	=	=	PROPN
eurjchem-701	103	58	11.51	11.51	NUM
eurjchem-701	103	59	±	±	NUM
eurjchem-701	103	60	0.45	0.45	NUM
eurjchem-701	103	61	µm	µm	NOUN
eurjchem-701	103	62	)	)	PUNCT
eurjchem-701	103	63	,	,	PUNCT
eurjchem-701	103	64	8i	8i	NUM
eurjchem-701	103	65	(	(	PUNCT
eurjchem-701	103	66	ic50	ic50	PROPN
eurjchem-701	103	67	=	=	PROPN
eurjchem-701	103	68	13.1	13.1	NUM
eurjchem-701	103	69	±	±	NUM
eurjchem-701	103	70	0.62	0.62	NUM
eurjchem-701	103	71	µm	µm	NOUN
eurjchem-701	103	72	)	)	PUNCT
eurjchem-701	103	73	,	,	PUNCT
eurjchem-701	103	74	8j	8j	NUM
eurjchem-701	103	75	(	(	PUNCT
eurjchem-701	103	76	ic50	ic50	PROPN
eurjchem-701	103	77	=	=	PROPN
eurjchem-701	103	78	14.0	14.0	NUM
eurjchem-701	103	79	±	±	NUM
eurjchem-701	103	80	0.42	0.42	NUM
eurjchem-701	103	81	µm	µm	NOUN
eurjchem-701	103	82	)	)	PUNCT
eurjchem-701	103	83	and	and	CCONJ
eurjchem-701	103	84	8k	8k	NUM
eurjchem-701	103	85	(	(	PUNCT
eurjchem-701	103	86	ic50	ic50	PROPN
eurjchem-701	103	87	=	=	PUNCT
eurjchem-701	103	88	14.5	14.5	NUM
eurjchem-701	103	89	±	±	NOUN
eurjchem-701	103	90	0.38	0.38	NUM
eurjchem-701	103	91	µm	µm	NOUN
eurjchem-701	103	92	)	)	PUNCT
eurjchem-701	103	93	demonstrated	demonstrate	VERB
eurjchem-701	103	94	moderate	moderate	ADJ
eurjchem-701	103	95	cytoxicity	cytoxicity	NOUN
eurjchem-701	103	96	,	,	PUNCT
eurjchem-701	103	97	while	while	SCONJ
eurjchem-701	103	98	compounds	compound	NOUN
eurjchem-701	103	99	8i	8i	NUM
eurjchem-701	103	100	,	,	PUNCT
eurjchem-701	103	101	8j	8j	NUM
eurjchem-701	103	102	and	and	CCONJ
eurjchem-701	103	103	mixture	mixture	NOUN
eurjchem-701	103	104	of	of	ADP
eurjchem-701	103	105	compounds	compound	NOUN
eurjchem-701	103	106	8n/9o	8n/9o	NUM
eurjchem-701	103	107	(	(	PUNCT
eurjchem-701	103	108	ic50	ic50	PROPN
eurjchem-701	103	109	>	>	SYM
eurjchem-701	103	110	30	30	NUM
eurjchem-701	103	111	)	)	PUNCT
eurjchem-701	103	112	exhibited	exhibit	VERB
eurjchem-701	103	113	a	a	DET
eurjchem-701	103	114	weak	weak	ADJ
eurjchem-701	103	115	activity	activity	NOUN
eurjchem-701	103	116	towards	towards	ADP
eurjchem-701	103	117	pc3	pc3	PROPN
eurjchem-701	103	118	cells	cell	NOUN
eurjchem-701	103	119	line	line	NOUN
eurjchem-701	103	120	.	.	PUNCT
eurjchem-701	104	1	however	however	ADV
eurjchem-701	104	2	,	,	PUNCT
eurjchem-701	104	3	in	in	ADP
eurjchem-701	104	4	the	the	DET
eurjchem-701	104	5	case	case	NOUN
eurjchem-701	104	6	of	of	ADP
eurjchem-701	104	7	hela	hela	PROPN
eurjchem-701	104	8	cell	cell	NOUN
eurjchem-701	104	9	line	line	NOUN
eurjchem-701	104	10	the	the	DET
eurjchem-701	104	11	compounds	compound	NOUN
eurjchem-701	104	12	8e	8e	X
eurjchem-701	104	13	(	(	PUNCT
eurjchem-701	104	14	ic50	ic50	PROPN
eurjchem-701	104	15	=	=	PROPN
eurjchem-701	104	16	9.67	9.67	NUM
eurjchem-701	104	17	±	±	NUM
eurjchem-701	104	18	0.20	0.20	NUM
eurjchem-701	104	19	µm	µm	NOUN
eurjchem-701	104	20	)	)	PUNCT
eurjchem-701	104	21	,	,	PUNCT
eurjchem-701	104	22	8f	8f	NOUN
eurjchem-701	104	23	(	(	PUNCT
eurjchem-701	104	24	ic50	ic50	PROPN
eurjchem-701	104	25	=	=	PROPN
eurjchem-701	104	26	11.26	11.26	NUM
eurjchem-701	104	27	±	±	NUM
eurjchem-701	104	28	0.85	0.85	NUM
eurjchem-701	104	29	µm	µm	NOUN
eurjchem-701	104	30	)	)	PUNCT
eurjchem-701	104	31	,	,	PUNCT
eurjchem-701	104	32	8k	8k	PROPN
eurjchem-701	104	33	(	(	PUNCT
eurjchem-701	104	34	ic50	ic50	PROPN
eurjchem-701	104	35	=	=	PROPN
eurjchem-701	104	36	14.73	14.73	NUM
eurjchem-701	104	37	±	±	NUM
eurjchem-701	104	38	52	52	NUM
eurjchem-701	104	39	hameed	hameed	NOUN
eurjchem-701	104	40	et	et	PROPN
eurjchem-701	104	41	al	al	PROPN
eurjchem-701	104	42	.	.	PUNCT
eurjchem-701	104	43	/	/	SYM
eurjchem-701	104	44	european	european	PROPN
eurjchem-701	104	45	journal	journal	PROPN
eurjchem-701	104	46	of	of	ADP
eurjchem-701	104	47	chemistry	chemistry	NOUN
eurjchem-701	104	48	4	4	NUM
eurjchem-701	104	49	(	(	PUNCT
eurjchem-701	104	50	1	1	NUM
eurjchem-701	104	51	)	)	PUNCT
eurjchem-701	104	52	(	(	PUNCT
eurjchem-701	104	53	2013	2013	NUM
eurjchem-701	104	54	)	)	PUNCT
eurjchem-701	104	55	49‐52	49‐52	NUM
eurjchem-701	104	56	0.14	0.14	NUM
eurjchem-701	104	57	µm	µm	NOUN
eurjchem-701	104	58	)	)	PUNCT
eurjchem-701	104	59	,	,	PUNCT
eurjchem-701	104	60	8d	8d	NUM
eurjchem-701	104	61	(	(	PUNCT
eurjchem-701	104	62	ic50	ic50	PROPN
eurjchem-701	104	63	=	=	SYM
eurjchem-701	104	64	14.67	14.67	NUM
eurjchem-701	104	65	±	±	NUM
eurjchem-701	104	66	0.75	0.75	NUM
eurjchem-701	104	67	µm	µm	NOUN
eurjchem-701	104	68	)	)	PUNCT
eurjchem-701	104	69	demonstrated	demonstrate	VERB
eurjchem-701	104	70	moderate	moderate	ADJ
eurjchem-701	104	71	cytoxicity	cytoxicity	NOUN
eurjchem-701	104	72	,	,	PUNCT
eurjchem-701	104	73	while	while	SCONJ
eurjchem-701	104	74	the	the	DET
eurjchem-701	104	75	compound	compound	NOUN
eurjchem-701	104	76	,	,	PUNCT
eurjchem-701	104	77	8c	8c	NUM
eurjchem-701	104	78	,	,	PUNCT
eurjchem-701	104	79	8	8	NUM
eurjchem-701	104	80	g	g	NOUN
eurjchem-701	104	81	,	,	PUNCT
eurjchem-701	104	82	8h	8h	NUM
eurjchem-701	104	83	,	,	PUNCT
eurjchem-701	104	84	8i	8i	NUM
eurjchem-701	104	85	,	,	PUNCT
eurjchem-701	104	86	8j	8j	NUM
eurjchem-701	104	87	,	,	PUNCT
eurjchem-701	104	88	8k	8k	NUM
eurjchem-701	104	89	,	,	PUNCT
eurjchem-701	104	90	8l	8l	NOUN
eurjchem-701	104	91	,	,	PUNCT
eurjchem-701	104	92	8	8	NUM
eurjchem-701	104	93	m	m	NOUN
eurjchem-701	104	94	,	,	PUNCT
eurjchem-701	104	95	8n/9o	8n/9o	NUM
eurjchem-701	104	96	exhibit	exhibit	VERB
eurjchem-701	104	97	very	very	ADV
eurjchem-701	104	98	low	low	ADJ
eurjchem-701	104	99	anticancer	anticancer	NOUN
eurjchem-701	104	100	activity	activity	NOUN
eurjchem-701	104	101	(	(	PUNCT
eurjchem-701	104	102	ic50	ic50	PROPN
eurjchem-701	104	103	=	=	PROPN
eurjchem-701	104	104	20.18	20.18	NUM
eurjchem-701	104	105	±	±	NUM
eurjchem-701	104	106	0.14	0.14	NUM
eurjchem-701	104	107	to	to	ADP
eurjchem-701	104	108	>	>	X
eurjchem-701	104	109	30	30	NUM
eurjchem-701	104	110	µm	µm	NOUN
eurjchem-701	104	111	)	)	PUNCT
eurjchem-701	104	112	against	against	ADP
eurjchem-701	104	113	hela	hela	PROPN
eurjchem-701	104	114	cell	cell	NOUN
eurjchem-701	104	115	line	line	NOUN
eurjchem-701	104	116	(	(	PUNCT
eurjchem-701	104	117	table	table	NOUN
eurjchem-701	104	118	3	3	NUM
eurjchem-701	104	119	)	)	PUNCT
eurjchem-701	104	120	.	.	PUNCT
eurjchem-701	105	1	the	the	DET
eurjchem-701	105	2	structure	structure	NOUN
eurjchem-701	105	3	activity	activity	NOUN
eurjchem-701	105	4	relationship	relationship	NOUN
eurjchem-701	105	5	showed	show	VERB
eurjchem-701	105	6	that	that	SCONJ
eurjchem-701	105	7	varying	vary	VERB
eurjchem-701	105	8	in	in	ADP
eurjchem-701	105	9	the	the	DET
eurjchem-701	105	10	anticancer	anticancer	NOUN
eurjchem-701	105	11	activity	activity	NOUN
eurjchem-701	105	12	in	in	ADP
eurjchem-701	105	13	both	both	DET
eurjchem-701	105	14	cell	cell	NOUN
eurjchem-701	105	15	lines	line	NOUN
eurjchem-701	105	16	again	again	ADV
eurjchem-701	105	17	depends	depend	VERB
eurjchem-701	105	18	upon	upon	SCONJ
eurjchem-701	105	19	position	position	NOUN
eurjchem-701	105	20	and	and	CCONJ
eurjchem-701	105	21	nature	nature	NOUN
eurjchem-701	105	22	of	of	ADP
eurjchem-701	105	23	the	the	DET
eurjchem-701	105	24	substituents	substituent	NOUN
eurjchem-701	105	25	on	on	ADP
eurjchem-701	105	26	the	the	DET
eurjchem-701	105	27	phenyl	phenyl	NOUN
eurjchem-701	105	28	ring	ring	NOUN
eurjchem-701	105	29	.	.	PUNCT
eurjchem-701	106	1	it	it	PRON
eurjchem-701	106	2	has	have	AUX
eurjchem-701	106	3	been	be	AUX
eurjchem-701	106	4	found	find	VERB
eurjchem-701	106	5	that	that	SCONJ
eurjchem-701	106	6	the	the	DET
eurjchem-701	106	7	4‐bromo	4‐bromo	NUM
eurjchem-701	106	8	derivative	derivative	ADJ
eurjchem-701	106	9	8a	8a	NUM
eurjchem-701	106	10	(	(	PUNCT
eurjchem-701	106	11	ic50	ic50	PROPN
eurjchem-701	106	12	=	=	PROPN
eurjchem-701	106	13	4.40	4.40	NUM
eurjchem-701	106	14	±	±	NUM
eurjchem-701	106	15	0.13	0.13	NUM
eurjchem-701	106	16	µm	µm	ADP
eurjchem-701	106	17	and	and	CCONJ
eurjchem-701	106	18	8.80	8.80	NUM
eurjchem-701	106	19	±	±	NUM
eurjchem-701	106	20	0.25	0.25	NUM
eurjchem-701	106	21	µm	µm	NOUN
eurjchem-701	106	22	)	)	PUNCT
eurjchem-701	106	23	and	and	CCONJ
eurjchem-701	106	24	4‐chloro	4‐chloro	NUM
eurjchem-701	106	25	derivative	derivative	ADJ
eurjchem-701	106	26	8b	8b	PROPN
eurjchem-701	106	27	(	(	PUNCT
eurjchem-701	106	28	ic50	ic50	PROPN
eurjchem-701	106	29	=	=	PROPN
eurjchem-701	106	30	6.85	6.85	NUM
eurjchem-701	106	31	±	±	NUM
eurjchem-701	106	32	0.34	0.34	NUM
eurjchem-701	106	33	µm	µm	NOUN
eurjchem-701	106	34	and	and	CCONJ
eurjchem-701	106	35	8.81	8.81	NUM
eurjchem-701	106	36	±	±	NUM
eurjchem-701	106	37	0.63	0.63	NUM
eurjchem-701	106	38	µm	µm	NOUN
eurjchem-701	106	39	)	)	PUNCT
eurjchem-701	106	40	are	be	AUX
eurjchem-701	106	41	most	most	ADV
eurjchem-701	106	42	cytotoxic	cytotoxic	ADJ
eurjchem-701	106	43	compounds	compound	NOUN
eurjchem-701	106	44	in	in	ADP
eurjchem-701	106	45	both	both	DET
eurjchem-701	106	46	cell	cell	NOUN
eurjchem-701	106	47	lines	line	NOUN
eurjchem-701	106	48	when	when	SCONJ
eurjchem-701	106	49	compared	compare	VERB
eurjchem-701	106	50	with	with	ADP
eurjchem-701	106	51	doxorubicin	doxorubicin	PROPN
eurjchem-701	106	52	value	value	NOUN
eurjchem-701	106	53	(	(	PUNCT
eurjchem-701	106	54	ic50	ic50	PROPN
eurjchem-701	106	55	=	=	PROPN
eurjchem-701	106	56	0.91	0.91	NUM
eurjchem-701	106	57	±	±	NUM
eurjchem-701	106	58	0.12	0.12	NUM
eurjchem-701	106	59	µm	µm	ADP
eurjchem-701	106	60	and	and	CCONJ
eurjchem-701	106	61	3.1	3.1	NUM
eurjchem-701	106	62	±	±	NUM
eurjchem-701	106	63	0.20	0.20	NUM
eurjchem-701	106	64	µm	µm	NOUN
eurjchem-701	106	65	)	)	PUNCT
eurjchem-701	106	66	.	.	PUNCT
eurjchem-701	107	1	the	the	DET
eurjchem-701	107	2	higher	high	ADJ
eurjchem-701	107	3	cytoxicity	cytoxicity	NOUN
eurjchem-701	107	4	of	of	ADP
eurjchem-701	107	5	these	these	DET
eurjchem-701	107	6	compounds	compound	NOUN
eurjchem-701	107	7	8a	8a	NUM
eurjchem-701	107	8	and	and	CCONJ
eurjchem-701	107	9	8b	8b	NUM
eurjchem-701	107	10	,	,	PUNCT
eurjchem-701	107	11	as	as	SCONJ
eurjchem-701	107	12	compared	compare	VERB
eurjchem-701	107	13	to	to	ADP
eurjchem-701	107	14	other	other	ADJ
eurjchem-701	107	15	compounds	compound	NOUN
eurjchem-701	107	16	in	in	ADP
eurjchem-701	107	17	the	the	DET
eurjchem-701	107	18	series	series	NOUN
eurjchem-701	107	19	(	(	PUNCT
eurjchem-701	107	20	8a‐n	8a‐n	PROPN
eurjchem-701	107	21	)	)	PUNCT
eurjchem-701	107	22	,	,	PUNCT
eurjchem-701	107	23	can	can	AUX
eurjchem-701	107	24	be	be	AUX
eurjchem-701	107	25	explained	explain	VERB
eurjchem-701	107	26	on	on	ADP
eurjchem-701	107	27	the	the	DET
eurjchem-701	107	28	basis	basis	NOUN
eurjchem-701	107	29	of	of	ADP
eurjchem-701	107	30	electronic	electronic	ADJ
eurjchem-701	107	31	effect	effect	NOUN
eurjchem-701	107	32	and	and	CCONJ
eurjchem-701	107	33	leaving	leave	VERB
eurjchem-701	107	34	group	group	NOUN
eurjchem-701	107	35	ability	ability	NOUN
eurjchem-701	107	36	of	of	ADP
eurjchem-701	107	37	substituents	substituent	NOUN
eurjchem-701	107	38	on	on	ADP
eurjchem-701	107	39	the	the	DET
eurjchem-701	107	40	aromatic	aromatic	ADJ
eurjchem-701	107	41	ring	ring	NOUN
eurjchem-701	107	42	.	.	PUNCT
eurjchem-701	108	1	the	the	DET
eurjchem-701	108	2	derivatives	derivative	NOUN
eurjchem-701	108	3	8a	8a	NUM
eurjchem-701	108	4	and	and	CCONJ
eurjchem-701	108	5	8b	8b	PROPN
eurjchem-701	108	6	bears	bear	NOUN
eurjchem-701	108	7	electron	electron	NOUN
eurjchem-701	108	8	withdrawing	withdraw	VERB
eurjchem-701	108	9	substituents	substituent	NOUN
eurjchem-701	108	10	at	at	ADP
eurjchem-701	108	11	4‐position	4‐position	PROPN
eurjchem-701	108	12	of	of	ADP
eurjchem-701	108	13	the	the	DET
eurjchem-701	108	14	aromatic	aromatic	ADJ
eurjchem-701	108	15	ring	ring	NOUN
eurjchem-701	108	16	,	,	PUNCT
eurjchem-701	108	17	so	so	CCONJ
eurjchem-701	108	18	if	if	SCONJ
eurjchem-701	108	19	this	this	PRON
eurjchem-701	108	20	is	be	AUX
eurjchem-701	108	21	only	only	ADJ
eurjchem-701	108	22	factor	factor	NOUN
eurjchem-701	108	23	of	of	ADP
eurjchem-701	108	24	cytotoxicity	cytotoxicity	NOUN
eurjchem-701	108	25	then	then	ADV
eurjchem-701	108	26	4‐nitro	4‐nitro	NUM
eurjchem-701	108	27	8n/9o	8n/9o	NUM
eurjchem-701	108	28	(	(	PUNCT
eurjchem-701	108	29	ic50	ic50	PROPN
eurjchem-701	108	30	>	>	SYM
eurjchem-701	108	31	30	30	NUM
eurjchem-701	108	32	µm	µm	NOUN
eurjchem-701	108	33	)	)	PUNCT
eurjchem-701	108	34	would	would	AUX
eurjchem-701	108	35	be	be	AUX
eurjchem-701	108	36	most	most	ADV
eurjchem-701	108	37	active	active	ADJ
eurjchem-701	108	38	than	than	ADP
eurjchem-701	108	39	the	the	DET
eurjchem-701	108	40	former	former	ADJ
eurjchem-701	108	41	derivatives	derivative	NOUN
eurjchem-701	108	42	in	in	ADP
eurjchem-701	108	43	the	the	DET
eurjchem-701	108	44	activity	activity	NOUN
eurjchem-701	108	45	table	table	NOUN
eurjchem-701	108	46	2	2	NUM
eurjchem-701	108	47	.	.	PUNCT
eurjchem-701	109	1	the	the	DET
eurjchem-701	109	2	lower	low	ADJ
eurjchem-701	109	3	activity	activity	NOUN
eurjchem-701	109	4	of	of	ADP
eurjchem-701	109	5	this	this	DET
eurjchem-701	109	6	compound	compound	NOUN
eurjchem-701	109	7	can	can	AUX
eurjchem-701	109	8	be	be	AUX
eurjchem-701	109	9	explained	explain	VERB
eurjchem-701	109	10	on	on	ADP
eurjchem-701	109	11	the	the	DET
eurjchem-701	109	12	basis	basis	NOUN
eurjchem-701	109	13	of	of	ADP
eurjchem-701	109	14	poor	poor	ADJ
eurjchem-701	109	15	leaving	leaving	NOUN
eurjchem-701	109	16	group	group	NOUN
eurjchem-701	109	17	ability	ability	NOUN
eurjchem-701	109	18	of	of	ADP
eurjchem-701	109	19	nitro	nitro	NOUN
eurjchem-701	109	20	group	group	NOUN
eurjchem-701	109	21	as	as	ADP
eurjchem-701	109	22	compared	compare	VERB
eurjchem-701	109	23	to	to	ADP
eurjchem-701	109	24	bromo	bromo	NOUN
eurjchem-701	109	25	and	and	CCONJ
eurjchem-701	109	26	chloro	chloro	NOUN
eurjchem-701	109	27	group	group	NOUN
eurjchem-701	109	28	.	.	PUNCT
eurjchem-701	110	1	the	the	DET
eurjchem-701	110	2	position	position	NOUN
eurjchem-701	110	3	of	of	ADP
eurjchem-701	110	4	the	the	DET
eurjchem-701	110	5	substituent	substituent	NOUN
eurjchem-701	110	6	is	be	AUX
eurjchem-701	110	7	also	also	ADV
eurjchem-701	110	8	play	play	VERB
eurjchem-701	110	9	a	a	DET
eurjchem-701	110	10	significant	significant	ADJ
eurjchem-701	110	11	role	role	NOUN
eurjchem-701	110	12	in	in	ADP
eurjchem-701	110	13	the	the	DET
eurjchem-701	110	14	anticancer	anticancer	NOUN
eurjchem-701	110	15	activity	activity	NOUN
eurjchem-701	110	16	.	.	PUNCT
eurjchem-701	111	1	the	the	DET
eurjchem-701	111	2	activity	activity	NOUN
eurjchem-701	111	3	of	of	ADP
eurjchem-701	111	4	3‐bromo	3‐bromo	NUM
eurjchem-701	111	5	derivative	derivative	ADJ
eurjchem-701	111	6	8f	8f	NOUN
eurjchem-701	111	7	(	(	PUNCT
eurjchem-701	111	8	ic50	ic50	PROPN
eurjchem-701	111	9	=	=	PROPN
eurjchem-701	111	10	9.62	9.62	NUM
eurjchem-701	111	11	±	±	NUM
eurjchem-701	111	12	0.55	0.55	NUM
eurjchem-701	111	13	and	and	CCONJ
eurjchem-701	111	14	11.26	11.26	NUM
eurjchem-701	111	15	±	±	NUM
eurjchem-701	111	16	0.85	0.85	NUM
eurjchem-701	111	17	µm	µm	NOUN
eurjchem-701	111	18	)	)	PUNCT
eurjchem-701	111	19	is	be	AUX
eurjchem-701	111	20	lower	low	ADJ
eurjchem-701	111	21	than	than	ADP
eurjchem-701	111	22	activity	activity	NOUN
eurjchem-701	111	23	of	of	ADP
eurjchem-701	111	24	4‐bromo	4‐bromo	NUM
eurjchem-701	111	25	derivative	derivative	ADJ
eurjchem-701	111	26	8a	8a	NUM
eurjchem-701	111	27	(	(	PUNCT
eurjchem-701	111	28	ic50	ic50	PROPN
eurjchem-701	111	29	=	=	PROPN
eurjchem-701	111	30	4.40	4.40	NUM
eurjchem-701	111	31	±	±	NUM
eurjchem-701	111	32	0.13	0.13	NUM
eurjchem-701	111	33	and	and	CCONJ
eurjchem-701	111	34	8.80	8.80	NUM
eurjchem-701	111	35	±	±	NUM
eurjchem-701	111	36	0.25	0.25	NUM
eurjchem-701	111	37	µm	µm	NOUN
eurjchem-701	111	38	)	)	PUNCT
eurjchem-701	111	39	,	,	PUNCT
eurjchem-701	111	40	whilst	whilst	SCONJ
eurjchem-701	111	41	in	in	ADP
eurjchem-701	111	42	the	the	DET
eurjchem-701	111	43	case	case	NOUN
eurjchem-701	111	44	of	of	ADP
eurjchem-701	111	45	3‐methoxy	3‐methoxy	NUM
eurjchem-701	111	46	derivative	derivative	ADJ
eurjchem-701	111	47	8h	8h	NOUN
eurjchem-701	111	48	(	(	PUNCT
eurjchem-701	111	49	ic50	ic50	PROPN
eurjchem-701	111	50	=	=	PROPN
eurjchem-701	111	51	11.51	11.51	NUM
eurjchem-701	111	52	±	±	NUM
eurjchem-701	111	53	0.45	0.45	NUM
eurjchem-701	111	54	and	and	CCONJ
eurjchem-701	111	55	20.19	20.19	NUM
eurjchem-701	111	56	±	±	NUM
eurjchem-701	111	57	0.39	0.39	NUM
eurjchem-701	111	58	µm	µm	NOUN
eurjchem-701	111	59	)	)	PUNCT
eurjchem-701	111	60	activity	activity	NOUN
eurjchem-701	111	61	is	be	AUX
eurjchem-701	111	62	slightly	slightly	ADV
eurjchem-701	111	63	higher	high	ADJ
eurjchem-701	111	64	than	than	ADP
eurjchem-701	111	65	4‐methoxy	4‐methoxy	NUM
eurjchem-701	111	66	derivative	derivative	ADJ
eurjchem-701	111	67	8k	8k	NOUN
eurjchem-701	111	68	(	(	PUNCT
eurjchem-701	111	69	ic50	ic50	PROPN
eurjchem-701	111	70	=	=	PROPN
eurjchem-701	111	71	14.55	14.55	NUM
eurjchem-701	111	72	±	±	NUM
eurjchem-701	111	73	0.38	0.38	NUM
eurjchem-701	111	74	and	and	CCONJ
eurjchem-701	111	75	14.73	14.73	NUM
eurjchem-701	111	76	±	±	NUM
eurjchem-701	111	77	0.14	0.14	NUM
eurjchem-701	111	78	µm	µm	NOUN
eurjchem-701	111	79	)	)	PUNCT
eurjchem-701	111	80	.	.	PUNCT
eurjchem-701	112	1	an	an	DET
eurjchem-701	112	2	addition	addition	NOUN
eurjchem-701	112	3	of	of	ADP
eurjchem-701	112	4	phenyl	phenyl	NOUN
eurjchem-701	112	5	ring	ring	NOUN
eurjchem-701	112	6	i.e.	i.e.	X
eurjchem-701	112	7	6‐	6‐	NUM
eurjchem-701	112	8	methoxynaphthalene	methoxynaphthalene	NOUN
eurjchem-701	112	9	dihydropyridine	dihydropyridine	NOUN
eurjchem-701	112	10	derivative	derivative	ADJ
eurjchem-701	112	11	8d	8d	NOUN
eurjchem-701	112	12	also	also	ADV
eurjchem-701	112	13	showed	show	VERB
eurjchem-701	112	14	significant	significant	ADJ
eurjchem-701	112	15	sensitivity	sensitivity	NOUN
eurjchem-701	112	16	(	(	PUNCT
eurjchem-701	112	17	ic50	ic50	PROPN
eurjchem-701	112	18	=	=	PROPN
eurjchem-701	112	19	8.36	8.36	NUM
eurjchem-701	112	20	±	±	NUM
eurjchem-701	112	21	0.48	0.48	NUM
eurjchem-701	112	22	and	and	CCONJ
eurjchem-701	112	23	14.67	14.67	NUM
eurjchem-701	112	24	±	±	NUM
eurjchem-701	112	25	0.75	0.75	NUM
eurjchem-701	112	26	µm	µm	NOUN
eurjchem-701	112	27	)	)	PUNCT
eurjchem-701	112	28	towards	towards	ADP
eurjchem-701	112	29	pc3	pc3	PROPN
eurjchem-701	112	30	cell	cell	NOUN
eurjchem-701	112	31	line	line	NOUN
eurjchem-701	112	32	and	and	CCONJ
eurjchem-701	112	33	hela	hela	ADJ
eurjchem-701	112	34	cell	cell	NOUN
eurjchem-701	112	35	line	line	NOUN
eurjchem-701	112	36	respectively	respectively	ADV
eurjchem-701	112	37	.	.	PUNCT
eurjchem-701	113	1	a	a	DET
eurjchem-701	113	2	future	future	ADJ
eurjchem-701	113	3	study	study	NOUN
eurjchem-701	113	4	on	on	ADP
eurjchem-701	113	5	such	such	ADJ
eurjchem-701	113	6	naphthalene	naphthalene	NOUN
eurjchem-701	113	7	derivatives	derivative	NOUN
eurjchem-701	113	8	will	will	AUX
eurjchem-701	113	9	carry	carry	VERB
eurjchem-701	113	10	out	out	ADP
eurjchem-701	113	11	to	to	PART
eurjchem-701	113	12	explore	explore	VERB
eurjchem-701	113	13	their	their	PRON
eurjchem-701	113	14	anticancer	anticancer	NOUN
eurjchem-701	113	15	potential	potential	NOUN
eurjchem-701	113	16	.	.	PUNCT
eurjchem-701	114	1	these	these	DET
eurjchem-701	114	2	anticancer	anticancer	NOUN
eurjchem-701	114	3	results	result	NOUN
eurjchem-701	114	4	concluded	conclude	VERB
eurjchem-701	114	5	that	that	SCONJ
eurjchem-701	114	6	electron	electron	NOUN
eurjchem-701	114	7	withdrawing	withdraw	VERB
eurjchem-701	114	8	group	group	NOUN
eurjchem-701	114	9	as	as	ADV
eurjchem-701	114	10	well	well	ADV
eurjchem-701	114	11	as	as	ADP
eurjchem-701	114	12	their	their	PRON
eurjchem-701	114	13	position	position	NOUN
eurjchem-701	114	14	on	on	ADP
eurjchem-701	114	15	the	the	DET
eurjchem-701	114	16	phenyl	phenyl	NOUN
eurjchem-701	114	17	ring	ring	NOUN
eurjchem-701	114	18	significantly	significantly	ADV
eurjchem-701	114	19	enhanced	enhance	VERB
eurjchem-701	114	20	the	the	DET
eurjchem-701	114	21	anticancer	anticancer	NOUN
eurjchem-701	114	22	activity	activity	NOUN
eurjchem-701	114	23	of	of	ADP
eurjchem-701	114	24	compounds	compound	NOUN
eurjchem-701	114	25	.	.	PUNCT
eurjchem-701	115	1	this	this	DET
eurjchem-701	115	2	study	study	NOUN
eurjchem-701	115	3	identifies	identify	VERB
eurjchem-701	115	4	compounds	compound	VERB
eurjchem-701	115	5	8a	8a	NUM
eurjchem-701	115	6	and	and	CCONJ
eurjchem-701	115	7	8b	8b	NUM
eurjchem-701	115	8	which	which	PRON
eurjchem-701	115	9	may	may	AUX
eurjchem-701	115	10	serve	serve	VERB
eurjchem-701	115	11	as	as	ADP
eurjchem-701	115	12	lead	lead	NOUN
eurjchem-701	115	13	compounds	compound	NOUN
eurjchem-701	115	14	for	for	ADP
eurjchem-701	115	15	the	the	DET
eurjchem-701	115	16	further	further	ADJ
eurjchem-701	115	17	research	research	NOUN
eurjchem-701	115	18	towards	towards	ADP
eurjchem-701	115	19	to	to	ADP
eurjchem-701	115	20	new	new	ADJ
eurjchem-701	115	21	therapeutic	therapeutic	ADJ
eurjchem-701	115	22	agents	agent	NOUN
eurjchem-701	115	23	or	or	CCONJ
eurjchem-701	115	24	linked	link	VERB
eurjchem-701	115	25	with	with	ADP
eurjchem-701	115	26	available	available	ADJ
eurjchem-701	115	27	drugs	drug	NOUN
eurjchem-701	115	28	to	to	PART
eurjchem-701	115	29	increase	increase	VERB
eurjchem-701	115	30	their	their	PRON
eurjchem-701	115	31	cytotoxic	cytotoxic	ADJ
eurjchem-701	115	32	effects	effect	NOUN
eurjchem-701	115	33	in	in	ADP
eurjchem-701	115	34	cancer	cancer	NOUN
eurjchem-701	115	35	resistance	resistance	NOUN
eurjchem-701	115	36	cells	cell	NOUN
eurjchem-701	115	37	.	.	PUNCT
eurjchem-701	116	1	4	4	X
eurjchem-701	116	2	.	.	X
eurjchem-701	116	3	conclusion	conclusion	VERB
eurjchem-701	116	4	a	a	DET
eurjchem-701	116	5	series	series	NOUN
eurjchem-701	116	6	of	of	ADP
eurjchem-701	116	7	5,6‐dihydropyridine	5,6‐dihydropyridine	NUM
eurjchem-701	116	8	derivatives	derivative	NOUN
eurjchem-701	116	9	have	have	AUX
eurjchem-701	116	10	been	be	AUX
eurjchem-701	116	11	prepared	prepare	VERB
eurjchem-701	116	12	under	under	ADP
eurjchem-701	116	13	solvent	solvent	ADJ
eurjchem-701	116	14	free	free	ADJ
eurjchem-701	116	15	conditions	condition	NOUN
eurjchem-701	116	16	in	in	ADP
eurjchem-701	116	17	good	good	ADJ
eurjchem-701	116	18	to	to	ADP
eurjchem-701	116	19	excellent	excellent	ADJ
eurjchem-701	116	20	yields	yield	NOUN
eurjchem-701	116	21	(	(	PUNCT
eurjchem-701	116	22	52‐95	52‐95	NUM
eurjchem-701	116	23	%	%	NOUN
eurjchem-701	116	24	)	)	PUNCT
eurjchem-701	116	25	.	.	PUNCT
eurjchem-701	117	1	this	this	DET
eurjchem-701	117	2	series	series	NOUN
eurjchem-701	117	3	has	have	AUX
eurjchem-701	117	4	been	be	AUX
eurjchem-701	117	5	tested	test	VERB
eurjchem-701	117	6	for	for	ADP
eurjchem-701	117	7	urease	urease	VERB
eurjchem-701	117	8	inhibitory	inhibitory	ADJ
eurjchem-701	117	9	activity	activity	NOUN
eurjchem-701	117	10	and	and	CCONJ
eurjchem-701	117	11	anticancer	anticancer	NOUN
eurjchem-701	117	12	activity	activity	NOUN
eurjchem-701	117	13	against	against	ADP
eurjchem-701	117	14	pc3	pc3	PROPN
eurjchem-701	117	15	and	and	CCONJ
eurjchem-701	117	16	hela	hela	PROPN
eurjchem-701	117	17	cell	cell	NOUN
eurjchem-701	117	18	lines	line	NOUN
eurjchem-701	117	19	.	.	PUNCT
eurjchem-701	118	1	the	the	DET
eurjchem-701	118	2	results	result	NOUN
eurjchem-701	118	3	of	of	ADP
eurjchem-701	118	4	these	these	DET
eurjchem-701	118	5	biological	biological	ADJ
eurjchem-701	118	6	assays	assay	NOUN
eurjchem-701	118	7	have	have	AUX
eurjchem-701	118	8	been	be	AUX
eurjchem-701	118	9	present	present	ADJ
eurjchem-701	118	10	in	in	ADP
eurjchem-701	118	11	table	table	NOUN
eurjchem-701	118	12	2	2	NUM
eurjchem-701	118	13	and	and	CCONJ
eurjchem-701	118	14	3	3	NUM
eurjchem-701	118	15	.	.	PUNCT
eurjchem-701	119	1	the	the	DET
eurjchem-701	119	2	compound	compound	NOUN
eurjchem-701	119	3	8k	8k	PROPN
eurjchem-701	119	4	was	be	AUX
eurjchem-701	119	5	found	find	VERB
eurjchem-701	119	6	to	to	PART
eurjchem-701	119	7	be	be	AUX
eurjchem-701	119	8	most	most	ADV
eurjchem-701	119	9	active	active	ADJ
eurjchem-701	119	10	ureases	urease	NOUN
eurjchem-701	119	11	inhibitor	inhibitor	NOUN
eurjchem-701	119	12	among	among	ADP
eurjchem-701	119	13	the	the	DET
eurjchem-701	119	14	series	series	NOUN
eurjchem-701	119	15	which	which	PRON
eurjchem-701	119	16	could	could	AUX
eurjchem-701	119	17	potentially	potentially	ADV
eurjchem-701	119	18	be	be	AUX
eurjchem-701	119	19	used	use	VERB
eurjchem-701	119	20	as	as	ADP
eurjchem-701	119	21	lead	lead	NOUN
eurjchem-701	119	22	for	for	ADP
eurjchem-701	119	23	further	further	ADJ
eurjchem-701	119	24	development	development	NOUN
eurjchem-701	119	25	of	of	ADP
eurjchem-701	119	26	drug	drug	NOUN
eurjchem-701	119	27	.	.	PUNCT
eurjchem-701	120	1	the	the	DET
eurjchem-701	120	2	anticancer	anticancer	NOUN
eurjchem-701	120	3	assays	assay	NOUN
eurjchem-701	120	4	explored	explore	VERB
eurjchem-701	120	5	that	that	SCONJ
eurjchem-701	120	6	compounds	compound	VERB
eurjchem-701	120	7	8a	8a	NUM
eurjchem-701	120	8	and	and	CCONJ
eurjchem-701	120	9	8b	8b	NUM
eurjchem-701	120	10	are	be	AUX
eurjchem-701	120	11	most	most	ADV
eurjchem-701	120	12	active	active	ADJ
eurjchem-701	120	13	cytotoxic	cytotoxic	ADJ
eurjchem-701	120	14	agents	agent	NOUN
eurjchem-701	120	15	in	in	ADP
eurjchem-701	120	16	the	the	DET
eurjchem-701	120	17	series	series	NOUN
eurjchem-701	120	18	.	.	PUNCT
eurjchem-701	121	1	these	these	DET
eurjchem-701	121	2	compounds	compound	NOUN
eurjchem-701	121	3	could	could	AUX
eurjchem-701	121	4	be	be	AUX
eurjchem-701	121	5	possibly	possibly	ADV
eurjchem-701	121	6	linked	link	VERB
eurjchem-701	121	7	with	with	ADP
eurjchem-701	121	8	doxorubicin	doxorubicin	PROPN
eurjchem-701	121	9	chemically	chemically	ADV
eurjchem-701	121	10	to	to	PART
eurjchem-701	121	11	overcome	overcome	VERB
eurjchem-701	121	12	drug	drug	NOUN
eurjchem-701	121	13	resistance	resistance	NOUN
eurjchem-701	121	14	offered	offer	VERB
eurjchem-701	121	15	by	by	ADP
eurjchem-701	121	16	over	over	ADP
eurjchem-701	121	17	expression	expression	NOUN
eurjchem-701	121	18	of	of	ADP
eurjchem-701	121	19	p‐	p‐	NOUN
eurjchem-701	121	20	glycoprotein	glycoprotein	NOUN
eurjchem-701	121	21	in	in	ADP
eurjchem-701	121	22	cancer	cancer	NOUN
eurjchem-701	121	23	cells	cell	NOUN
eurjchem-701	121	24	.	.	PUNCT
eurjchem-701	122	1	these	these	PRON
eurjchem-701	122	2	compounds	compound	VERB
eurjchem-701	122	3	8a	8a	NUM
eurjchem-701	122	4	and	and	CCONJ
eurjchem-701	122	5	8b	8b	PROPN
eurjchem-701	122	6	can	can	AUX
eurjchem-701	122	7	also	also	ADV
eurjchem-701	122	8	be	be	AUX
eurjchem-701	122	9	used	use	VERB
eurjchem-701	122	10	as	as	ADP
eurjchem-701	122	11	lead	lead	NOUN
eurjchem-701	122	12	compounds	compound	NOUN
eurjchem-701	122	13	for	for	ADP
eurjchem-701	122	14	further	further	ADJ
eurjchem-701	122	15	development	development	NOUN
eurjchem-701	122	16	of	of	ADP
eurjchem-701	122	17	drugs	drug	NOUN
eurjchem-701	122	18	.	.	PUNCT
eurjchem-701	123	1	acknowledgements	acknowledgement	NOUN
eurjchem-701	123	2	we	we	PRON
eurjchem-701	123	3	are	be	AUX
eurjchem-701	123	4	thankful	thankful	ADJ
eurjchem-701	123	5	to	to	ADP
eurjchem-701	123	6	higher	high	ADJ
eurjchem-701	123	7	education	education	NOUN
eurjchem-701	123	8	commission	commission	NOUN
eurjchem-701	123	9	(	(	PUNCT
eurjchem-701	123	10	hec	hec	PROPN
eurjchem-701	123	11	)	)	PUNCT
eurjchem-701	123	12	,	,	PUNCT
eurjchem-701	123	13	pakistan	pakistan	PROPN
eurjchem-701	123	14	and	and	CCONJ
eurjchem-701	123	15	husein	husein	PROPN
eurjchem-701	123	16	ebrahim	ebrahim	PROPN
eurjchem-701	123	17	jamal	jamal	PROPN
eurjchem-701	123	18	research	research	PROPN
eurjchem-701	123	19	institute	institute	PROPN
eurjchem-701	123	20	of	of	ADP
eurjchem-701	123	21	chemistry	chemistry	PROPN
eurjchem-701	123	22	,	,	PUNCT
eurjchem-701	123	23	international	international	ADJ
eurjchem-701	123	24	center	center	NOUN
eurjchem-701	123	25	for	for	ADP
eurjchem-701	123	26	chemical	chemical	NOUN
eurjchem-701	123	27	and	and	CCONJ
eurjchem-701	123	28	biological	biological	ADJ
eurjchem-701	123	29	sciences	science	NOUN
eurjchem-701	123	30	,	,	PUNCT
eurjchem-701	123	31	university	university	PROPN
eurjchem-701	123	32	of	of	ADP
eurjchem-701	123	33	karachi	karachi	PROPN
eurjchem-701	123	34	,	,	PUNCT
eurjchem-701	123	35	karachi‐75270	karachi‐75270	PROPN
eurjchem-701	123	36	,	,	PUNCT
eurjchem-701	123	37	pakistan	pakistan	PROPN
eurjchem-701	123	38	for	for	ADP
eurjchem-701	123	39	providing	provide	VERB
eurjchem-701	123	40	financial	financial	ADJ
eurjchem-701	123	41	support	support	NOUN
eurjchem-701	123	42	.	.	PUNCT
eurjchem-701	124	1	references	reference	NOUN
eurjchem-701	124	2	[	[	X
eurjchem-701	124	3	1	1	NUM
eurjchem-701	124	4	]	]	PUNCT
eurjchem-701	124	5	.	.	PUNCT
eurjchem-701	125	1	hargreaves	hargreaves	PROPN
eurjchem-701	125	2	,	,	PUNCT
eurjchem-701	125	3	s.	s.	PROPN
eurjchem-701	125	4	l.	l.	PROPN
eurjchem-701	125	5	;	;	PUNCT
eurjchem-701	125	6	pilkington	pilkington	PROPN
eurjchem-701	125	7	,	,	PUNCT
eurjchem-701	125	8	b.	b.	PROPN
eurjchem-701	125	9	l.	l.	PROPN
eurjchem-701	125	10	;	;	PUNCT
eurjchem-701	125	11	russell	russell	PROPN
eurjchem-701	125	12	,	,	PUNCT
eurjchem-701	125	13	s.	s.	PROPN
eurjchem-701	125	14	e.	e.	PROPN
eurjchem-701	125	15	;	;	PUNCT
eurjchem-701	125	16	worthington	worthington	PROPN
eurjchem-701	125	17	,	,	PUNCT
eurjchem-701	125	18	p.	p.	NOUN
eurjchem-701	125	19	a.	a.	NOUN
eurjchem-701	125	20	tetrahedron	tetrahedron	PROPN
eurjchem-701	125	21	lett	lett	PROPN
eurjchem-701	125	22	.	.	PROPN
eurjchem-701	126	1	2000	2000	NUM
eurjchem-701	126	2	,	,	PUNCT
eurjchem-701	126	3	41	41	NUM
eurjchem-701	126	4	,	,	PUNCT
eurjchem-701	126	5	1653‐1656	1653‐1656	NUM
eurjchem-701	126	6	.	.	PUNCT
eurjchem-701	127	1	[	[	X
eurjchem-701	127	2	2	2	NUM
eurjchem-701	127	3	]	]	PUNCT
eurjchem-701	127	4	.	.	PUNCT
eurjchem-701	128	1	malicorne	malicorne	VERB
eurjchem-701	128	2	,	,	PUNCT
eurjchem-701	128	3	g.	g.	PROPN
eurjchem-701	128	4	;	;	PUNCT
eurjchem-701	128	5	bompart	bompart	PROPN
eurjchem-701	128	6	,	,	PUNCT
eurjchem-701	128	7	j.	j.	PROPN
eurjchem-701	128	8	;	;	PUNCT
eurjchem-701	128	9	giral	giral	ADJ
eurjchem-701	128	10	,	,	PUNCT
eurjchem-701	128	11	l.	l.	PROPN
eurjchem-701	128	12	;	;	PUNCT
eurjchem-701	128	13	despaux	despaux	PROPN
eurjchem-701	128	14	,	,	PUNCT
eurjchem-701	128	15	e.	e.	PROPN
eurjchem-701	128	16	eur	eur	PROPN
eurjchem-701	128	17	.	.	PUNCT
eurjchem-701	129	1	j.	j.	PROPN
eurjchem-701	129	2	med	med	PROPN
eurjchem-701	129	3	.	.	PROPN
eurjchem-701	129	4	chem	chem	PROPN
eurjchem-701	129	5	.	.	PUNCT
eurjchem-701	130	1	1991	1991	NUM
eurjchem-701	130	2	,	,	PUNCT
eurjchem-701	130	3	26	26	NUM
eurjchem-701	130	4	,	,	PUNCT
eurjchem-701	130	5	3‐11	3‐11	NUM
eurjchem-701	130	6	.	.	PUNCT
eurjchem-701	131	1	[	[	X
eurjchem-701	131	2	3	3	NUM
eurjchem-701	131	3	]	]	PUNCT
eurjchem-701	131	4	.	.	PUNCT
eurjchem-701	132	1	szoko	szoko	PROPN
eurjchem-701	132	2	,	,	PUNCT
eurjchem-701	132	3	e.	e.	PROPN
eurjchem-701	132	4	;	;	PUNCT
eurjchem-701	132	5	tabi	tabi	PROPN
eurjchem-701	132	6	,	,	PUNCT
eurjchem-701	132	7	t.	t.	PROPN
eurjchem-701	132	8	j.	j.	PROPN
eurjchem-701	132	9	pharm	pharm	PROPN
eurjchem-701	132	10	,	,	PUNCT
eurjchem-701	132	11	biomed	biome	VERB
eurjchem-701	132	12	.	.	PUNCT
eurjchem-701	133	1	anal	anal	PROPN
eurjchem-701	133	2	.	.	PUNCT
eurjchem-701	134	1	2010	2010	NUM
eurjchem-701	134	2	,	,	PUNCT
eurjchem-701	134	3	53	53	NUM
eurjchem-701	134	4	,	,	PUNCT
eurjchem-701	134	5	1180‐1192	1180‐1192	X
eurjchem-701	134	6	.	.	PUNCT
eurjchem-701	135	1	[	[	X
eurjchem-701	135	2	4	4	NUM
eurjchem-701	135	3	]	]	PUNCT
eurjchem-701	135	4	.	.	PUNCT
eurjchem-701	136	1	hameed	hameed	PROPN
eurjchem-701	136	2	,	,	PUNCT
eurjchem-701	136	3	a.	a.	PROPN
eurjchem-701	136	4	;	;	PUNCT
eurjchem-701	136	5	anwar	anwar	PROPN
eurjchem-701	136	6	,	,	PUNCT
eurjchem-701	136	7	a.	a.	PROPN
eurjchem-701	136	8	;	;	PUNCT
eurjchem-701	136	9	yousaf	yousaf	PROPN
eurjchem-701	136	10	,	,	PUNCT
eurjchem-701	136	11	s.	s.	PROPN
eurjchem-701	136	12	;	;	PUNCT
eurjchem-701	136	13	khan	khan	PROPN
eurjchem-701	136	14	,	,	PUNCT
eurjchem-701	136	15	k.	k.	PROPN
eurjchem-701	136	16	m.	m.	PROPN
eurjchem-701	136	17	;	;	PUNCT
eurjchem-701	136	18	basha	basha	PROPN
eurjchem-701	136	19	,	,	PUNCT
eurjchem-701	136	20	f.	f.	PROPN
eurjchem-701	136	21	z.	z.	PROPN
eurjchem-701	136	22	eur	eur	PROPN
eurjchem-701	136	23	.	.	PUNCT
eurjchem-701	137	1	j.	j.	PROPN
eurjchem-701	137	2	chem	chem	PROPN
eurjchem-701	137	3	.	.	PUNCT
eurjchem-701	138	1	2012	2012	NUM
eurjchem-701	138	2	,	,	PUNCT
eurjchem-701	138	3	3	3	NUM
eurjchem-701	138	4	,	,	PUNCT
eurjchem-701	138	5	179‐185	179‐185	NUM
eurjchem-701	138	6	.	.	PUNCT
eurjchem-701	139	1	[	[	X
eurjchem-701	139	2	5	5	NUM
eurjchem-701	139	3	]	]	PUNCT
eurjchem-701	139	4	.	.	PUNCT
eurjchem-701	140	1	burne	burne	PROPN
eurjchem-701	140	2	,	,	PUNCT
eurjchem-701	140	3	r.	r.	PROPN
eurjchem-701	140	4	a.	a.	PROPN
eurjchem-701	140	5	;	;	PUNCT
eurjchem-701	140	6	chen	chen	PROPN
eurjchem-701	140	7	,	,	PUNCT
eurjchem-701	140	8	y.‐y	y.‐y	PROPN
eurjchem-701	140	9	.	.	PUNCT
eurjchem-701	141	1	m.	m.	NOUN
eurjchem-701	141	2	microbes	microbe	NOUN
eurjchem-701	141	3	and	and	CCONJ
eurjchem-701	141	4	infect	infect	VERB
eurjchem-701	141	5	.	.	PUNCT
eurjchem-701	142	1	2000	2000	NUM
eurjchem-701	142	2	,	,	PUNCT
eurjchem-701	142	3	2	2	NUM
eurjchem-701	142	4	,	,	PUNCT
eurjchem-701	142	5	533‐542	533‐542	NUM
eurjchem-701	142	6	.	.	PUNCT
eurjchem-701	143	1	[	[	X
eurjchem-701	143	2	6	6	NUM
eurjchem-701	143	3	]	]	PUNCT
eurjchem-701	143	4	.	.	PUNCT
eurjchem-701	144	1	mobley	mobley	PROPN
eurjchem-701	144	2	,	,	PUNCT
eurjchem-701	144	3	h.	h.	PROPN
eurjchem-701	144	4	l.	l.	PROPN
eurjchem-701	144	5	t.	t.	PROPN
eurjchem-701	144	6	;	;	PUNCT
eurjchem-701	144	7	hausinger	hausinger	NOUN
eurjchem-701	144	8	,	,	PUNCT
eurjchem-701	144	9	r.	r.	PROPN
eurjchem-701	144	10	p.	p.	PROPN
eurjchem-701	144	11	microbiol	microbiol	PROPN
eurjchem-701	144	12	.	.	PUNCT
eurjchem-701	145	1	rev	rev	PROPN
eurjchem-701	145	2	.	.	PROPN
eurjchem-701	145	3	1989	1989	NUM
eurjchem-701	145	4	,	,	PUNCT
eurjchem-701	145	5	53	53	NUM
eurjchem-701	145	6	,	,	PUNCT
eurjchem-701	145	7	85‐100	85‐100	NUM
eurjchem-701	145	8	.	.	PUNCT
eurjchem-701	146	1	[	[	X
eurjchem-701	146	2	7	7	NUM
eurjchem-701	146	3	]	]	PUNCT
eurjchem-701	146	4	.	.	PUNCT
eurjchem-701	147	1	menna	menna	PROPN
eurjchem-701	147	2	,	,	PUNCT
eurjchem-701	147	3	p.	p.	PROPN
eurjchem-701	147	4	;	;	PUNCT
eurjchem-701	147	5	gonzalez	gonzalez	PROPN
eurjchem-701	147	6	paz	paz	PROPN
eurjchem-701	147	7	,	,	PUNCT
eurjchem-701	147	8	o.	o.	PROPN
eurjchem-701	147	9	;	;	PUNCT
eurjchem-701	147	10	chello	chello	PROPN
eurjchem-701	147	11	,	,	PUNCT
eurjchem-701	147	12	m.	m.	NOUN
eurjchem-701	147	13	;	;	PUNCT
eurjchem-701	147	14	covino	covino	PROPN
eurjchem-701	147	15	,	,	PUNCT
eurjchem-701	147	16	e.	e.	PROPN
eurjchem-701	147	17	;	;	PUNCT
eurjchem-701	147	18	salvatorelli	salvatorelli	PROPN
eurjchem-701	147	19	,	,	PUNCT
eurjchem-701	147	20	e.	e.	PROPN
eurjchem-701	147	21	;	;	PUNCT
eurjchem-701	147	22	minotti	minotti	PROPN
eurjchem-701	147	23	,	,	PUNCT
eurjchem-701	147	24	g.	g.	PROPN
eurjchem-701	147	25	expet	expet	PROPN
eurjchem-701	147	26	.	.	PUNCT
eurjchem-701	148	1	opin	opin	NOUN
eurjchem-701	148	2	.	.	PUNCT
eurjchem-701	149	1	drug	drug	PROPN
eurjchem-701	149	2	saf	saf	PROPN
eurjchem-701	149	3	.	.	PROPN
eurjchem-701	149	4	2012	2012	NUM
eurjchem-701	149	5	,	,	PUNCT
eurjchem-701	149	6	11	11	NUM
eurjchem-701	149	7	,	,	PUNCT
eurjchem-701	149	8	s21‐s36	s21‐s36	PROPN
eurjchem-701	149	9	.	.	PUNCT
eurjchem-701	150	1	[	[	X
eurjchem-701	150	2	8	8	NUM
eurjchem-701	150	3	]	]	PUNCT
eurjchem-701	150	4	.	.	PUNCT
eurjchem-701	151	1	koch	koch	PROPN
eurjchem-701	151	2	,	,	PUNCT
eurjchem-701	151	3	t.	t.	PROPN
eurjchem-701	151	4	;	;	PUNCT
eurjchem-701	151	5	barthel	barthel	PROPN
eurjchem-701	151	6	,	,	PUNCT
eurjchem-701	151	7	b.	b.	PROPN
eurjchem-701	151	8	;	;	PUNCT
eurjchem-701	151	9	kalet	kalet	PROPN
eurjchem-701	151	10	,	,	PUNCT
eurjchem-701	151	11	b.	b.	PROPN
eurjchem-701	151	12	;	;	PUNCT
eurjchem-701	151	13	rudnicki	rudnicki	PROPN
eurjchem-701	151	14	,	,	PUNCT
eurjchem-701	151	15	d.	d.	PROPN
eurjchem-701	151	16	;	;	PUNCT
eurjchem-701	151	17	post	post	PROPN
eurjchem-701	151	18	,	,	PUNCT
eurjchem-701	151	19	g.	g.	PROPN
eurjchem-701	151	20	;	;	PUNCT
eurjchem-701	151	21	burkhart	burkhart	PROPN
eurjchem-701	151	22	,	,	PUNCT
eurjchem-701	151	23	d.	d.	PROPN
eurjchem-701	151	24	:	:	PUNCT
eurjchem-701	151	25	anthracycline‐formaldehyde	anthracycline‐formaldehyde	NOUN
eurjchem-701	151	26	conjugates	conjugate	NOUN
eurjchem-701	151	27	and	and	CCONJ
eurjchem-701	151	28	their	their	PRON
eurjchem-701	151	29	targeted	target	VERB
eurjchem-701	151	30	prodrugs	prodrug	NOUN
eurjchem-701	151	31	anthracycline	anthracycline	VERB
eurjchem-701	151	32	chemistry	chemistry	NOUN
eurjchem-701	151	33	and	and	CCONJ
eurjchem-701	151	34	biology	biology	PROPN
eurjchem-701	151	35	ii	ii	PROPN
eurjchem-701	151	36	.	.	PUNCT
eurjchem-701	152	1	krohn	krohn	PROPN
eurjchem-701	152	2	,	,	PUNCT
eurjchem-701	152	3	k.	k.	PROPN
eurjchem-701	152	4	,	,	PUNCT
eurjchem-701	152	5	ed	ed	NOUN
eurjchem-701	152	6	.	.	PUNCT
eurjchem-701	152	7	;	;	PUNCT
eurjchem-701	152	8	springer	springer	PROPN
eurjchem-701	152	9	berlin	berlin	PROPN
eurjchem-701	152	10	/	/	SYM
eurjchem-701	152	11	heidelberg	heidelberg	PROPN
eurjchem-701	152	12	,	,	PUNCT
eurjchem-701	152	13	2008	2008	NUM
eurjchem-701	152	14	,	,	PUNCT
eurjchem-701	152	15	283	283	NUM
eurjchem-701	152	16	,	,	PUNCT
eurjchem-701	152	17	141‐170	141‐170	NUM
eurjchem-701	152	18	.	.	PUNCT
eurjchem-701	153	1	[	[	X
eurjchem-701	153	2	9	9	NUM
eurjchem-701	153	3	]	]	PUNCT
eurjchem-701	153	4	.	.	PUNCT
eurjchem-701	153	5	talelli	talelli	PROPN
eurjchem-701	153	6	,	,	PUNCT
eurjchem-701	153	7	m.	m.	NOUN
eurjchem-701	153	8	;	;	PUNCT
eurjchem-701	153	9	morita	morita	PROPN
eurjchem-701	153	10	,	,	PUNCT
eurjchem-701	153	11	k.	k.	PROPN
eurjchem-701	153	12	;	;	PUNCT
eurjchem-701	153	13	rijcken	rijcken	VERB
eurjchem-701	153	14	,	,	PUNCT
eurjchem-701	153	15	c.	c.	PROPN
eurjchem-701	153	16	j.	j.	PROPN
eurjchem-701	153	17	;	;	PUNCT
eurjchem-701	153	18	aben	aben	PROPN
eurjchem-701	153	19	,	,	PUNCT
eurjchem-701	153	20	r.	r.	PROPN
eurjchem-701	153	21	w.	w.	PROPN
eurjchem-701	153	22	;	;	PUNCT
eurjchem-701	153	23	lammers	lammer	NOUN
eurjchem-701	153	24	,	,	PUNCT
eurjchem-701	153	25	t.	t.	PROPN
eurjchem-701	153	26	;	;	PUNCT
eurjchem-701	153	27	scheeren	scheeren	PROPN
eurjchem-701	153	28	,	,	PUNCT
eurjchem-701	153	29	h.	h.	PROPN
eurjchem-701	153	30	w.	w.	PROPN
eurjchem-701	153	31	;	;	PUNCT
eurjchem-701	153	32	van	van	PROPN
eurjchem-701	153	33	nostrum	nostrum	NOUN
eurjchem-701	153	34	,	,	PUNCT
eurjchem-701	153	35	c.	c.	PROPN
eurjchem-701	153	36	f.	f.	PROPN
eurjchem-701	153	37	;	;	PUNCT
eurjchem-701	153	38	storm	storm	NOUN
eurjchem-701	153	39	,	,	PUNCT
eurjchem-701	153	40	g.	g.	PROPN
eurjchem-701	153	41	;	;	PUNCT
eurjchem-701	153	42	hennink	hennink	VERB
eurjchem-701	153	43	,	,	PUNCT
eurjchem-701	153	44	w.	w.	PROPN
eurjchem-701	153	45	e.	e.	PROPN
eurjchem-701	153	46	bioconjug	bioconjug	PROPN
eurjchem-701	153	47	.	.	PUNCT
eurjchem-701	154	1	chem	chem	PROPN
eurjchem-701	154	2	.	.	PUNCT
eurjchem-701	155	1	2011	2011	NUM
eurjchem-701	155	2	,	,	PUNCT
eurjchem-701	155	3	22	22	NUM
eurjchem-701	155	4	,	,	PUNCT
eurjchem-701	155	5	2519‐2530	2519‐2530	NOUN
eurjchem-701	155	6	.	.	PUNCT
eurjchem-701	156	1	[	[	X
eurjchem-701	156	2	10	10	NUM
eurjchem-701	156	3	]	]	PUNCT
eurjchem-701	156	4	.	.	PUNCT
eurjchem-701	157	1	volm	volm	NOUN
eurjchem-701	157	2	,	,	PUNCT
eurjchem-701	157	3	m.	m.	NOUN
eurjchem-701	157	4	;	;	PUNCT
eurjchem-701	157	5	mattern	mattern	PROPN
eurjchem-701	157	6	,	,	PUNCT
eurjchem-701	157	7	j.	j.	PROPN
eurjchem-701	157	8	;	;	PUNCT
eurjchem-701	157	9	samsel	samsel	PROPN
eurjchem-701	157	10	,	,	PUNCT
eurjchem-701	157	11	b.	b.	PROPN
eurjchem-701	157	12	br	br	PROPN
eurjchem-701	157	13	.	.	PUNCT
eurjchem-701	158	1	j.	j.	PROPN
eurjchem-701	158	2	cancer	cancer	PROPN
eurjchem-701	158	3	1991	1991	NUM
eurjchem-701	158	4	,	,	PUNCT
eurjchem-701	158	5	64	64	NUM
eurjchem-701	158	6	,	,	PUNCT
eurjchem-701	158	7	700‐704	700‐704	NUM
eurjchem-701	158	8	.	.	PUNCT
eurjchem-701	159	1	[	[	X
eurjchem-701	159	2	11	11	NUM
eurjchem-701	159	3	]	]	PUNCT
eurjchem-701	159	4	.	.	PUNCT
eurjchem-701	159	5	toyota	toyota	PROPN
eurjchem-701	159	6	,	,	PUNCT
eurjchem-701	159	7	k.	k.	PROPN
eurjchem-701	159	8	;	;	PUNCT
eurjchem-701	159	9	shinkai	shinkai	PROPN
eurjchem-701	159	10	,	,	PUNCT
eurjchem-701	159	11	h.	h.	PROPN
eurjchem-701	159	12	;	;	PUNCT
eurjchem-701	159	13	eto	eto	PROPN
eurjchem-701	159	14	,	,	PUNCT
eurjchem-701	159	15	h.	h.	PROPN
eurjchem-701	159	16	;	;	PUNCT
eurjchem-701	159	17	kamimura	kamimura	ADV
eurjchem-701	159	18	,	,	PUNCT
eurjchem-701	159	19	a.	a.	NOUN
eurjchem-701	159	20	;	;	PUNCT
eurjchem-701	159	21	eguchi	eguchi	NOUN
eurjchem-701	159	22	,	,	PUNCT
eurjchem-701	159	23	c.	c.	NOUN
eurjchem-701	159	24	;	;	PUNCT
eurjchem-701	159	25	ohsumi	ohsumi	PROPN
eurjchem-701	159	26	,	,	PUNCT
eurjchem-701	159	27	k.	k.	PROPN
eurjchem-701	159	28	;	;	PUNCT
eurjchem-701	159	29	tsuruo	tsuruo	ADV
eurjchem-701	159	30	,	,	PUNCT
eurjchem-701	159	31	t.	t.	PROPN
eurjchem-701	159	32	u.s	u.s	PROPN
eurjchem-701	159	33	.	.	PROPN
eurjchem-701	159	34	patent	patent	NOUN
eurjchem-701	159	35	application	application	NOUN
eurjchem-701	159	36	5216172	5216172	NUM
eurjchem-701	159	37	,	,	PUNCT
eurjchem-701	159	38	1993	1993	NUM
eurjchem-701	159	39	.	.	PUNCT
eurjchem-701	160	1	01.07	01.07	NUM
eurjchem-701	160	2	.	.	PUNCT
eurjchem-701	161	1	[	[	X
eurjchem-701	161	2	12	12	NUM
eurjchem-701	161	3	]	]	PUNCT
eurjchem-701	161	4	.	.	PUNCT
eurjchem-701	162	1	abadi	abadi	PROPN
eurjchem-701	162	2	,	,	PUNCT
eurjchem-701	162	3	a.	a.	PROPN
eurjchem-701	162	4	h.	h.	PROPN
eurjchem-701	162	5	;	;	PUNCT
eurjchem-701	162	6	ibrahim	ibrahim	PROPN
eurjchem-701	162	7	,	,	PUNCT
eurjchem-701	162	8	t.	t.	NOUN
eurjchem-701	162	9	m.	m.	NOUN
eurjchem-701	162	10	;	;	PUNCT
eurjchem-701	162	11	abouzid	abouzid	PROPN
eurjchem-701	162	12	,	,	PUNCT
eurjchem-701	162	13	k.	k.	PROPN
eurjchem-701	162	14	m.	m.	PROPN
eurjchem-701	162	15	;	;	PUNCT
eurjchem-701	162	16	lehmann	lehmann	PROPN
eurjchem-701	162	17	,	,	PUNCT
eurjchem-701	162	18	j.	j.	PROPN
eurjchem-701	162	19	;	;	PUNCT
eurjchem-701	162	20	tinsley	tinsley	PROPN
eurjchem-701	162	21	,	,	PUNCT
eurjchem-701	162	22	h.	h.	PROPN
eurjchem-701	162	23	n.	n.	PROPN
eurjchem-701	162	24	;	;	PUNCT
eurjchem-701	162	25	gary	gary	PROPN
eurjchem-701	162	26	,	,	PUNCT
eurjchem-701	162	27	b.	b.	PROPN
eurjchem-701	162	28	d.	d.	PROPN
eurjchem-701	162	29	;	;	PUNCT
eurjchem-701	162	30	piazza	piazza	NOUN
eurjchem-701	162	31	,	,	PUNCT
eurjchem-701	162	32	g.	g.	PROPN
eurjchem-701	162	33	a.	a.	NOUN
eurjchem-701	162	34	bioorg	bioorg	PROPN
eurjchem-701	162	35	.	.	PUNCT
eurjchem-701	163	1	med	med	PROPN
eurjchem-701	163	2	.	.	PUNCT
eurjchem-701	163	3	chem	chem	PROPN
eurjchem-701	163	4	.	.	PUNCT
eurjchem-701	164	1	2009	2009	NUM
eurjchem-701	164	2	,	,	PUNCT
eurjchem-701	164	3	17	17	NUM
eurjchem-701	164	4	,	,	PUNCT
eurjchem-701	164	5	5974‐5982	5974‐5982	NUM
eurjchem-701	164	6	.	.	PUNCT
eurjchem-701	165	1	[	[	X
eurjchem-701	165	2	13	13	NUM
eurjchem-701	165	3	]	]	PUNCT
eurjchem-701	165	4	.	.	PUNCT
eurjchem-701	166	1	weatherburn	weatherburn	NOUN
eurjchem-701	166	2	,	,	PUNCT
eurjchem-701	166	3	m.	m.	NOUN
eurjchem-701	166	4	w.	w.	PROPN
eurjchem-701	166	5	anal	anal	PROPN
eurjchem-701	166	6	.	.	PUNCT
eurjchem-701	167	1	chem	chem	PROPN
eurjchem-701	167	2	.	.	PUNCT
eurjchem-701	168	1	1967	1967	NUM
eurjchem-701	168	2	,	,	PUNCT
eurjchem-701	168	3	39	39	NUM
eurjchem-701	168	4	,	,	PUNCT
eurjchem-701	168	5	971‐974	971‐974	NUM
eurjchem-701	168	6	.	.	PUNCT
eurjchem-701	169	1	[	[	X
eurjchem-701	169	2	14	14	NUM
eurjchem-701	169	3	]	]	PUNCT
eurjchem-701	169	4	.	.	PUNCT
eurjchem-701	170	1	mosmann	mosmann	PROPN
eurjchem-701	170	2	,	,	PUNCT
eurjchem-701	170	3	t.	t.	PROPN
eurjchem-701	170	4	j.	j.	PROPN
eurjchem-701	170	5	immunol	immunol	PROPN
eurjchem-701	170	6	.	.	PUNCT
eurjchem-701	171	1	methods	method	NOUN
eurjchem-701	171	2	1983	1983	NUM
eurjchem-701	171	3	,	,	PUNCT
eurjchem-701	171	4	65	65	NUM
eurjchem-701	171	5	,	,	PUNCT
eurjchem-701	171	6	55‐63	55‐63	NUM
eurjchem-701	171	7	.	.	PUNCT