id	sid	tid	token	lemma	pos
eurjchem-885	1	1	untitled	untitle	VERB
eurjchem-885	1	2	european	european	PROPN
eurjchem-885	1	3	journal	journal	PROPN
eurjchem-885	1	4	of	of	ADP
eurjchem-885	1	5	chemistry	chemistry	NOUN
eurjchem-885	1	6	5	5	NUM
eurjchem-885	1	7	(	(	PUNCT
eurjchem-885	1	8	1	1	NUM
eurjchem-885	1	9	)	)	PUNCT
eurjchem-885	1	10	(	(	PUNCT
eurjchem-885	1	11	2014	2014	NUM
eurjchem-885	1	12	)	)	PUNCT
eurjchem-885	1	13	11‐17	11‐17	PROPN
eurjchem-885	1	14	european	european	PROPN
eurjchem-885	1	15	journal	journal	PROPN
eurjchem-885	1	16	of	of	ADP
eurjchem-885	1	17	chemistry	chemistry	NOUN
eurjchem-885	1	18	issn	issn	PROPN
eurjchem-885	1	19	2153‐2249	2153‐2249	PROPN
eurjchem-885	1	20	(	(	PUNCT
eurjchem-885	1	21	print	print	NOUN
eurjchem-885	1	22	)	)	PUNCT
eurjchem-885	1	23	/	/	SYM
eurjchem-885	1	24	issn	issn	PROPN
eurjchem-885	1	25	2153‐2257	2153‐2257	NUM
eurjchem-885	1	26	(	(	PUNCT
eurjchem-885	1	27	online	online	ADJ
eurjchem-885	1	28	)	)	PUNCT
eurjchem-885	1	29			NOUN
eurjchem-885	1	30	2014	2014	NUM
eurjchem-885	2	1	eurjchem	eurjchem	PROPN
eurjchem-885	2	2	publishing	publish	VERB
eurjchem-885	2	3	‐	‐	NOUN
eurjchem-885	2	4	printed	print	VERB
eurjchem-885	2	5	in	in	ADP
eurjchem-885	2	6	the	the	DET
eurjchem-885	2	7	usa	usa	PROPN
eurjchem-885	2	8	http://dx.doi.org/10.5155/eurjchem.5.1.11‐17.885	http://dx.doi.org/10.5155/eurjchem.5.1.11‐17.885	PROPN
eurjchem-885	2	9	european	european	PROPN
eurjchem-885	2	10	journal	journal	PROPN
eurjchem-885	2	11	of	of	ADP
eurjchem-885	2	12	chemistry	chemistry	PROPN
eurjchem-885	2	13	journal	journal	PROPN
eurjchem-885	2	14	homepage	homepage	NOUN
eurjchem-885	2	15	:	:	PUNCT
eurjchem-885	2	16	www.eurjchem.com	www.eurjchem.com	X
eurjchem-885	2	17	micellar	micellar	ADJ
eurjchem-885	2	18	high	high	ADJ
eurjchem-885	2	19	performance	performance	NOUN
eurjchem-885	2	20	liquid	liquid	ADJ
eurjchem-885	2	21	chromatographic	chromatographic	ADJ
eurjchem-885	2	22	determination	determination	NOUN
eurjchem-885	2	23	of	of	ADP
eurjchem-885	2	24	itraconazole	itraconazole	NOUN
eurjchem-885	2	25	in	in	ADP
eurjchem-885	2	26	bulk	bulk	NOUN
eurjchem-885	2	27	,	,	PUNCT
eurjchem-885	2	28	pharmaceutical	pharmaceutical	ADJ
eurjchem-885	2	29	dosage	dosage	NOUN
eurjchem-885	2	30	forms	form	NOUN
eurjchem-885	2	31	and	and	CCONJ
eurjchem-885	2	32	human	human	ADJ
eurjchem-885	2	33	plasma	plasma	NOUN
eurjchem-885	2	34	mohamed	mohamed	PROPN
eurjchem-885	2	35	rizk	rizk	PROPN
eurjchem-885	2	36	,	,	PUNCT
eurjchem-885	2	37	safaa	safaa	VERB
eurjchem-885	2	38	shafik	shafik	NOUN
eurjchem-885	2	39	toubar	toubar	NOUN
eurjchem-885	2	40	,	,	PUNCT
eurjchem-885	2	41	maha	maha	PROPN
eurjchem-885	2	42	mahmoud	mahmoud	PROPN
eurjchem-885	2	43	abou	abou	PROPN
eurjchem-885	2	44	el‐alamin	el‐alamin	PROPN
eurjchem-885	2	45	*	*	PUNCT
eurjchem-885	2	46	,	,	PUNCT
eurjchem-885	2	47	and	and	CCONJ
eurjchem-885	2	48	marwa	marwa	PROPN
eurjchem-885	2	49	mohamed	mohamed	PROPN
eurjchem-885	2	50	mahmoud	mahmoud	PROPN
eurjchem-885	2	51	azab	azab	ADP
eurjchem-885	2	52	analytical	analytical	ADJ
eurjchem-885	2	53	chemistry	chemistry	NOUN
eurjchem-885	2	54	department	department	NOUN
eurjchem-885	2	55	,	,	PUNCT
eurjchem-885	2	56	faculty	faculty	NOUN
eurjchem-885	2	57	of	of	ADP
eurjchem-885	2	58	pharmacy	pharmacy	NOUN
eurjchem-885	2	59	,	,	PUNCT
eurjchem-885	2	60	helwan	helwan	PROPN
eurjchem-885	2	61	university	university	PROPN
eurjchem-885	2	62	,	,	PUNCT
eurjchem-885	2	63	11795	11795	NUM
eurjchem-885	2	64	,	,	PUNCT
eurjchem-885	2	65	cairo	cairo	PROPN
eurjchem-885	2	66	,	,	PUNCT
eurjchem-885	2	67	egypt	egypt	PROPN
eurjchem-885	2	68	*	*	PUNCT
eurjchem-885	2	69	corresponding	correspond	VERB
eurjchem-885	2	70	author	author	NOUN
eurjchem-885	2	71	at	at	ADP
eurjchem-885	2	72	:	:	PUNCT
eurjchem-885	2	73	analytical	analytical	ADJ
eurjchem-885	2	74	chemistry	chemistry	NOUN
eurjchem-885	2	75	department	department	NOUN
eurjchem-885	2	76	,	,	PUNCT
eurjchem-885	2	77	faculty	faculty	NOUN
eurjchem-885	2	78	of	of	ADP
eurjchem-885	2	79	pharmacy	pharmacy	NOUN
eurjchem-885	2	80	,	,	PUNCT
eurjchem-885	2	81	helwan	helwan	PROPN
eurjchem-885	2	82	university	university	PROPN
eurjchem-885	2	83	,	,	PUNCT
eurjchem-885	2	84	11795	11795	NUM
eurjchem-885	2	85	,	,	PUNCT
eurjchem-885	2	86	cairo	cairo	PROPN
eurjchem-885	2	87	,	,	PUNCT
eurjchem-885	2	88	egypt	egypt	PROPN
eurjchem-885	2	89	.	.	PUNCT
eurjchem-885	3	1	tel	tel	PROPN
eurjchem-885	3	2	.	.	PROPN
eurjchem-885	3	3	:	:	PUNCT
eurjchem-885	4	1	+2.02.25541601	+2.02.25541601	PROPN
eurjchem-885	4	2	.	.	PUNCT
eurjchem-885	4	3	fax	fax	NOUN
eurjchem-885	4	4	:	:	PUNCT
eurjchem-885	4	5	+2.02.25541601	+2.02.25541601	PROPN
eurjchem-885	4	6	.	.	PUNCT
eurjchem-885	4	7	e‐mail	e‐mail	PUNCT
eurjchem-885	4	8	address	address	NOUN
eurjchem-885	4	9	:	:	PUNCT
eurjchem-885	4	10	dr.maha.alamin@gmail.com	dr.maha.alamin@gmail.com	PROPN
eurjchem-885	4	11	(	(	PUNCT
eurjchem-885	4	12	m.m.a	m.m.a	NOUN
eurjchem-885	4	13	.	.	PUNCT
eurjchem-885	4	14	el‐alamin	el‐alamin	PROPN
eurjchem-885	4	15	)	)	PUNCT
eurjchem-885	4	16	.	.	PUNCT
eurjchem-885	5	1	article	article	NOUN
eurjchem-885	5	2	information	information	PROPN
eurjchem-885	5	3	abstract	abstract	ADJ
eurjchem-885	5	4	doi	doi	PROPN
eurjchem-885	5	5	:	:	PUNCT
eurjchem-885	5	6	10.5155	10.5155	NUM
eurjchem-885	5	7	/	/	SYM
eurjchem-885	5	8	eurjchem.5.1.11‐17.885	eurjchem.5.1.11‐17.885	NOUN
eurjchem-885	5	9	received	receive	VERB
eurjchem-885	5	10	:	:	PUNCT
eurjchem-885	5	11	25	25	NUM
eurjchem-885	5	12	july	july	PROPN
eurjchem-885	5	13	2013	2013	NUM
eurjchem-885	5	14	received	receive	VERB
eurjchem-885	5	15	in	in	ADP
eurjchem-885	5	16	revised	revise	VERB
eurjchem-885	5	17	form	form	NOUN
eurjchem-885	5	18	:	:	PUNCT
eurjchem-885	5	19	13	13	NUM
eurjchem-885	5	20	august	august	PROPN
eurjchem-885	5	21	2013	2013	NUM
eurjchem-885	5	22	accepted	accept	VERB
eurjchem-885	5	23	:	:	PUNCT
eurjchem-885	5	24	13	13	NUM
eurjchem-885	5	25	august	august	PROPN
eurjchem-885	5	26	2013	2013	NUM
eurjchem-885	5	27	online	online	NOUN
eurjchem-885	5	28	:	:	PUNCT
eurjchem-885	5	29	31	31	NUM
eurjchem-885	5	30	march	march	NOUN
eurjchem-885	5	31	2014	2014	NUM
eurjchem-885	5	32	keywords	keyword	VERB
eurjchem-885	5	33	a	a	DET
eurjchem-885	5	34	micellar	micellar	ADJ
eurjchem-885	5	35	liquid	liquid	ADJ
eurjchem-885	5	36	chromatographic	chromatographic	ADJ
eurjchem-885	5	37	method	method	NOUN
eurjchem-885	5	38	was	be	AUX
eurjchem-885	5	39	developed	develop	VERB
eurjchem-885	5	40	for	for	ADP
eurjchem-885	5	41	determination	determination	NOUN
eurjchem-885	5	42	of	of	ADP
eurjchem-885	5	43	itraconazole	itraconazole	NOUN
eurjchem-885	5	44	in	in	ADP
eurjchem-885	5	45	bulk	bulk	NOUN
eurjchem-885	5	46	,	,	PUNCT
eurjchem-885	5	47	dosage	dosage	NOUN
eurjchem-885	5	48	form	form	NOUN
eurjchem-885	5	49	and	and	CCONJ
eurjchem-885	5	50	human	human	ADJ
eurjchem-885	5	51	plasma	plasma	NOUN
eurjchem-885	5	52	using	use	VERB
eurjchem-885	5	53	µbondapack	µbondapack	NOUN
eurjchem-885	5	54	cyano	cyano	NOUN
eurjchem-885	5	55	column	column	NOUN
eurjchem-885	5	56	and	and	CCONJ
eurjchem-885	5	57	a	a	DET
eurjchem-885	5	58	mobile	mobile	ADJ
eurjchem-885	5	59	phase	phase	NOUN
eurjchem-885	5	60	consisting	consist	VERB
eurjchem-885	5	61	of	of	ADP
eurjchem-885	5	62	0.1	0.1	NUM
eurjchem-885	5	63	m	m	NOUN
eurjchem-885	5	64	sodium	sodium	NOUN
eurjchem-885	5	65	dodecyl	dodecyl	PROPN
eurjchem-885	5	66	sulphate	sulphate	NOUN
eurjchem-885	5	67	,	,	PUNCT
eurjchem-885	5	68	20	20	NUM
eurjchem-885	5	69	%	%	NOUN
eurjchem-885	5	70	1‐propanol	1‐propanol	NOUN
eurjchem-885	5	71	,	,	PUNCT
eurjchem-885	5	72	0.3	0.3	NUM
eurjchem-885	5	73	%	%	NOUN
eurjchem-885	5	74	triethylamine	triethylamine	NOUN
eurjchem-885	5	75	in	in	ADP
eurjchem-885	5	76	0.02	0.02	NUM
eurjchem-885	5	77	m	m	NOUN
eurjchem-885	5	78	orthophosphoric	orthophosphoric	ADJ
eurjchem-885	5	79	acid	acid	NOUN
eurjchem-885	5	80	(	(	PUNCT
eurjchem-885	5	81	ph	ph	NOUN
eurjchem-885	5	82	=	=	NOUN
eurjchem-885	5	83	3.5	3.5	NUM
eurjchem-885	5	84	)	)	PUNCT
eurjchem-885	5	85	.	.	PUNCT
eurjchem-885	6	1	the	the	DET
eurjchem-885	6	2	uv	uv	NOUN
eurjchem-885	6	3	detection	detection	NOUN
eurjchem-885	6	4	was	be	AUX
eurjchem-885	6	5	achieved	achieve	VERB
eurjchem-885	6	6	at	at	ADP
eurjchem-885	6	7	258	258	NUM
eurjchem-885	6	8	nm	nm	NOUN
eurjchem-885	6	9	.	.	PUNCT
eurjchem-885	7	1	various	various	ADJ
eurjchem-885	7	2	chromatographic	chromatographic	ADJ
eurjchem-885	7	3	parameters	parameter	NOUN
eurjchem-885	7	4	were	be	AUX
eurjchem-885	7	5	studied	study	VERB
eurjchem-885	7	6	,	,	PUNCT
eurjchem-885	7	7	e.g.	e.g.	ADV
eurjchem-885	7	8	types	type	NOUN
eurjchem-885	7	9	of	of	ADP
eurjchem-885	7	10	columns	column	NOUN
eurjchem-885	7	11	,	,	PUNCT
eurjchem-885	7	12	ph	ph	NOUN
eurjchem-885	7	13	of	of	ADP
eurjchem-885	7	14	mobile	mobile	ADJ
eurjchem-885	7	15	phase	phase	NOUN
eurjchem-885	7	16	,	,	PUNCT
eurjchem-885	7	17	concentration	concentration	NOUN
eurjchem-885	7	18	of	of	ADP
eurjchem-885	7	19	sodium	sodium	NOUN
eurjchem-885	7	20	dodecyl	dodecyl	NOUN
eurjchem-885	7	21	sulphate	sulphate	NOUN
eurjchem-885	7	22	,	,	PUNCT
eurjchem-885	7	23	1‐propanol	1‐propanol	NUM
eurjchem-885	7	24	,	,	PUNCT
eurjchem-885	7	25	triethylamine	triethylamine	NOUN
eurjchem-885	7	26	,	,	PUNCT
eurjchem-885	7	27	etc	etc	X
eurjchem-885	7	28	.the	.the	PRON
eurjchem-885	7	29	method	method	NOUN
eurjchem-885	7	30	was	be	AUX
eurjchem-885	7	31	linear	linear	ADJ
eurjchem-885	7	32	over	over	ADP
eurjchem-885	7	33	the	the	DET
eurjchem-885	7	34	concentration	concentration	NOUN
eurjchem-885	7	35	range	range	NOUN
eurjchem-885	7	36	16.4‐320.0	16.4‐320.0	NOUN
eurjchem-885	7	37	µg	µg	NOUN
eurjchem-885	7	38	/	/	SYM
eurjchem-885	7	39	ml	ml	NOUN
eurjchem-885	7	40	with	with	ADP
eurjchem-885	7	41	regression	regression	NOUN
eurjchem-885	7	42	coefficient	coefficient	NOUN
eurjchem-885	7	43	0.999	0.999	NUM
eurjchem-885	7	44	and	and	CCONJ
eurjchem-885	7	45	limit	limit	NOUN
eurjchem-885	7	46	of	of	ADP
eurjchem-885	7	47	detection	detection	NOUN
eurjchem-885	7	48	5.4	5.4	NUM
eurjchem-885	7	49	µg	µg	NOUN
eurjchem-885	7	50	/	/	SYM
eurjchem-885	7	51	ml	ml	ADV
eurjchem-885	7	52	in	in	ADP
eurjchem-885	7	53	bulk	bulk	NOUN
eurjchem-885	7	54	.	.	PUNCT
eurjchem-885	8	1	inter	inter	PROPN
eurjchem-885	8	2	and	and	CCONJ
eurjchem-885	8	3	intra‐day	intra‐day	NOUN
eurjchem-885	8	4	results	result	NOUN
eurjchem-885	8	5	showed	show	VERB
eurjchem-885	8	6	%	%	INTJ
eurjchem-885	8	7	rsd	rsd	NOUN
eurjchem-885	8	8	<	<	X
eurjchem-885	8	9	1.49	1.49	NUM
eurjchem-885	8	10	%	%	NOUN
eurjchem-885	8	11	.	.	PUNCT
eurjchem-885	9	1	the	the	DET
eurjchem-885	9	2	result	result	NOUN
eurjchem-885	9	3	obtained	obtain	VERB
eurjchem-885	9	4	by	by	ADP
eurjchem-885	9	5	the	the	DET
eurjchem-885	9	6	proposed	propose	VERB
eurjchem-885	9	7	method	method	NOUN
eurjchem-885	9	8	was	be	AUX
eurjchem-885	9	9	compared	compare	VERB
eurjchem-885	9	10	with	with	ADP
eurjchem-885	9	11	that	that	PRON
eurjchem-885	9	12	obtained	obtain	VERB
eurjchem-885	9	13	by	by	ADP
eurjchem-885	9	14	the	the	DET
eurjchem-885	9	15	reference	reference	NOUN
eurjchem-885	9	16	hplc	hplc	NOUN
eurjchem-885	9	17	technique	technique	NOUN
eurjchem-885	9	18	.	.	PUNCT
eurjchem-885	10	1	furthermore	furthermore	ADV
eurjchem-885	10	2	,	,	PUNCT
eurjchem-885	10	3	the	the	DET
eurjchem-885	10	4	proposed	propose	VERB
eurjchem-885	10	5	method	method	NOUN
eurjchem-885	10	6	was	be	AUX
eurjchem-885	10	7	successfully	successfully	ADV
eurjchem-885	10	8	applied	apply	VERB
eurjchem-885	10	9	as	as	ADP
eurjchem-885	10	10	stability‐	stability‐	NOUN
eurjchem-885	10	11	indicating	indicate	VERB
eurjchem-885	10	12	method	method	NOUN
eurjchem-885	10	13	for	for	ADP
eurjchem-885	10	14	determination	determination	NOUN
eurjchem-885	10	15	of	of	ADP
eurjchem-885	10	16	itraconazole	itraconazole	NOUN
eurjchem-885	10	17	under	under	ADP
eurjchem-885	10	18	different	different	ADJ
eurjchem-885	10	19	stressed	stressed	ADJ
eurjchem-885	10	20	conditions	condition	NOUN
eurjchem-885	10	21	.	.	PUNCT
eurjchem-885	11	1	the	the	DET
eurjchem-885	11	2	method	method	NOUN
eurjchem-885	11	3	showed	show	VERB
eurjchem-885	11	4	good	good	ADJ
eurjchem-885	11	5	selectivity	selectivity	NOUN
eurjchem-885	11	6	,	,	PUNCT
eurjchem-885	11	7	repeatability	repeatability	NOUN
eurjchem-885	11	8	,	,	PUNCT
eurjchem-885	11	9	linearity	linearity	NOUN
eurjchem-885	11	10	and	and	CCONJ
eurjchem-885	11	11	sensitivity	sensitivity	NOUN
eurjchem-885	11	12	according	accord	VERB
eurjchem-885	11	13	to	to	ADP
eurjchem-885	11	14	the	the	DET
eurjchem-885	11	15	evaluation	evaluation	NOUN
eurjchem-885	11	16	of	of	ADP
eurjchem-885	11	17	the	the	DET
eurjchem-885	11	18	validation	validation	NOUN
eurjchem-885	11	19	parameters	parameter	NOUN
eurjchem-885	11	20	.	.	PUNCT
eurjchem-885	12	1	stability	stability	NOUN
eurjchem-885	12	2	itraconazole	itraconazole	NOUN
eurjchem-885	12	3	anti‐fungal	anti‐fungal	ADJ
eurjchem-885	12	4	drugs	drug	NOUN
eurjchem-885	12	5	method	method	VERB
eurjchem-885	12	6	validation	validation	NOUN
eurjchem-885	12	7	micellar	micellar	ADJ
eurjchem-885	12	8	liquid	liquid	ADJ
eurjchem-885	12	9	chromatography	chromatography	NOUN
eurjchem-885	12	10	optimization	optimization	NOUN
eurjchem-885	12	11	and	and	CCONJ
eurjchem-885	12	12	system	system	NOUN
eurjchem-885	12	13	suitability	suitability	NOUN
eurjchem-885	12	14	1	1	NUM
eurjchem-885	12	15	.	.	PUNCT
eurjchem-885	13	1	introduction	introduction	NOUN
eurjchem-885	13	2	itraconazole	itraconazole	PROPN
eurjchem-885	13	3	(	(	PUNCT
eurjchem-885	13	4	itc	itc	PROPN
eurjchem-885	13	5	)	)	PUNCT
eurjchem-885	13	6	,	,	PUNCT
eurjchem-885	13	7	is	be	AUX
eurjchem-885	13	8	a	a	DET
eurjchem-885	13	9	triazole	triazole	NOUN
eurjchem-885	13	10	compound	compound	NOUN
eurjchem-885	13	11	,	,	PUNCT
eurjchem-885	13	12	chemically	chemically	ADV
eurjchem-885	13	13	described	describe	VERB
eurjchem-885	13	14	as	as	ADP
eurjchem-885	13	15	(	(	PUNCT
eurjchem-885	13	16	2r,4s)‐rel‐1‐(butan‐2‐yl)‐4‐{4‐[4‐(4‐{[(2r,4s)‐2‐	2r,4s)‐rel‐1‐(butan‐2‐yl)‐4‐{4‐[4‐(4‐{[(2r,4s)‐2‐	NUM
eurjchem-885	13	17	(	(	PUNCT
eurjchem-885	13	18	2,4‐dichlorophenyl)‐2‐(1h‐1,2,4‐triazol‐1‐ylmethyl)‐1,3‐dioxo	2,4‐dichlorophenyl)‐2‐(1h‐1,2,4‐triazol‐1‐ylmethyl)‐1,3‐dioxo	NUM
eurjchem-885	13	19	lan‐4‐yl]methoxy}phenyl)piperazin‐1‐yl]phenyl}‐4,5‐dihydro‐	lan‐4‐yl]methoxy}phenyl)piperazin‐1‐yl]phenyl}‐4,5‐dihydro‐	NOUN
eurjchem-885	13	20	1h‐1,2,4‐triazol‐5‐one	1h‐1,2,4‐triazol‐5‐one	NUM
eurjchem-885	13	21	(	(	PUNCT
eurjchem-885	13	22	figure	figure	NOUN
eurjchem-885	13	23	1	1	NUM
eurjchem-885	13	24	)	)	PUNCT
eurjchem-885	13	25	.	.	PUNCT
eurjchem-885	14	1	it	it	PRON
eurjchem-885	14	2	is	be	AUX
eurjchem-885	14	3	an	an	DET
eurjchem-885	14	4	orally	orally	ADV
eurjchem-885	14	5	active	active	ADJ
eurjchem-885	14	6	anti‐	anti‐	PROPN
eurjchem-885	14	7	fungal	fungal	ADJ
eurjchem-885	14	8	drug	drug	NOUN
eurjchem-885	14	9	and	and	CCONJ
eurjchem-885	14	10	extensively	extensively	ADV
eurjchem-885	14	11	metabolized	metabolize	VERB
eurjchem-885	14	12	in	in	ADP
eurjchem-885	14	13	the	the	DET
eurjchem-885	14	14	liver	liver	NOUN
eurjchem-885	14	15	by	by	ADP
eurjchem-885	14	16	the	the	DET
eurjchem-885	14	17	cytochrome	cytochrome	NOUN
eurjchem-885	14	18	p450	p450	NUM
eurjchem-885	14	19	isoenzymes	isoenzyme	NOUN
eurjchem-885	14	20	.	.	PUNCT
eurjchem-885	15	1	itc	itc	PROPN
eurjchem-885	15	2	inhibits	inhibit	VERB
eurjchem-885	15	3	fungi	fungi	NOUN
eurjchem-885	15	4	ergosterol	ergosterol	NOUN
eurjchem-885	15	5	synthesis	synthesis	NOUN
eurjchem-885	15	6	.	.	PUNCT
eurjchem-885	16	1	depletion	depletion	NOUN
eurjchem-885	16	2	of	of	ADP
eurjchem-885	16	3	ergosterol	ergosterol	NOUN
eurjchem-885	16	4	in	in	ADP
eurjchem-885	16	5	fungal	fungal	ADJ
eurjchem-885	16	6	membrane	membrane	NOUN
eurjchem-885	16	7	disrupts	disrupt	VERB
eurjchem-885	16	8	the	the	DET
eurjchem-885	16	9	structure	structure	NOUN
eurjchem-885	16	10	and	and	CCONJ
eurjchem-885	16	11	many	many	ADJ
eurjchem-885	16	12	functions	function	NOUN
eurjchem-885	16	13	of	of	ADP
eurjchem-885	16	14	fungal	fungal	ADJ
eurjchem-885	16	15	membrane	membrane	NOUN
eurjchem-885	16	16	leading	lead	VERB
eurjchem-885	16	17	to	to	ADP
eurjchem-885	16	18	inhibition	inhibition	NOUN
eurjchem-885	16	19	of	of	ADP
eurjchem-885	16	20	fungal	fungal	ADJ
eurjchem-885	16	21	growth	growth	NOUN
eurjchem-885	16	22	[	[	X
eurjchem-885	16	23	1	1	NUM
eurjchem-885	16	24	]	]	PUNCT
eurjchem-885	16	25	.	.	PUNCT
eurjchem-885	17	1	figure	figure	NOUN
eurjchem-885	17	2	1	1	NUM
eurjchem-885	17	3	.	.	PUNCT
eurjchem-885	17	4	chemical	chemical	ADJ
eurjchem-885	17	5	structure	structure	NOUN
eurjchem-885	17	6	of	of	ADP
eurjchem-885	17	7	itc	itc	PROPN
eurjchem-885	17	8	.	.	PUNCT
eurjchem-885	18	1	itc	itc	PROPN
eurjchem-885	18	2	bulk	bulk	ADJ
eurjchem-885	18	3	drug	drug	NOUN
eurjchem-885	18	4	is	be	AUX
eurjchem-885	18	5	official	official	ADJ
eurjchem-885	18	6	in	in	ADP
eurjchem-885	18	7	british	british	ADJ
eurjchem-885	18	8	pharmacopeia	pharmacopeia	NOUN
eurjchem-885	19	1	[	[	X
eurjchem-885	19	2	2	2	NUM
eurjchem-885	19	3	]	]	PUNCT
eurjchem-885	19	4	and	and	CCONJ
eurjchem-885	19	5	in	in	ADP
eurjchem-885	19	6	european	european	ADJ
eurjchem-885	19	7	pharmacopeia	pharmacopeia	PROPN
eurjchem-885	19	8	[	[	X
eurjchem-885	19	9	3	3	NUM
eurjchem-885	19	10	]	]	PUNCT
eurjchem-885	19	11	and	and	CCONJ
eurjchem-885	19	12	assayed	assayed	ADJ
eurjchem-885	19	13	using	use	VERB
eurjchem-885	19	14	non‐aqueous	non‐aqueous	ADJ
eurjchem-885	19	15	titration	titration	NOUN
eurjchem-885	19	16	.	.	PUNCT
eurjchem-885	20	1	many	many	ADJ
eurjchem-885	20	2	methods	method	NOUN
eurjchem-885	20	3	for	for	ADP
eurjchem-885	20	4	analysis	analysis	NOUN
eurjchem-885	20	5	of	of	ADP
eurjchem-885	20	6	the	the	DET
eurjchem-885	20	7	cited	cite	VERB
eurjchem-885	20	8	compound	compound	NOUN
eurjchem-885	20	9	have	have	AUX
eurjchem-885	20	10	been	be	AUX
eurjchem-885	20	11	reported	report	VERB
eurjchem-885	20	12	,	,	PUNCT
eurjchem-885	20	13	e.g.	e.g.	ADV
eurjchem-885	20	14	high	high	ADJ
eurjchem-885	20	15	pressure	pressure	NOUN
eurjchem-885	20	16	liquid	liquid	NOUN
eurjchem-885	20	17	chromatography	chromatography	NOUN
eurjchem-885	20	18	(	(	PUNCT
eurjchem-885	20	19	hplc	hplc	PROPN
eurjchem-885	20	20	)	)	PUNCT
eurjchem-885	21	1	[	[	X
eurjchem-885	21	2	4‐12	4‐12	NUM
eurjchem-885	21	3	]	]	X
eurjchem-885	21	4	,	,	PUNCT
eurjchem-885	21	5	liquid	liquid	ADJ
eurjchem-885	21	6	chromatography‐mass	chromatography‐mass	NOUN
eurjchem-885	21	7	spectrometry	spectrometry	NOUN
eurjchem-885	21	8	(	(	PUNCT
eurjchem-885	21	9	lc‐	lc‐	ADJ
eurjchem-885	21	10	ms‐ms	ms‐ms	NUM
eurjchem-885	21	11	)	)	PUNCT
eurjchem-885	22	1	[	[	X
eurjchem-885	22	2	13‐16	13‐16	X
eurjchem-885	22	3	]	]	PUNCT
eurjchem-885	22	4	,	,	PUNCT
eurjchem-885	22	5	electrokinetic	electrokinetic	ADJ
eurjchem-885	22	6	chromatography	chromatography	NOUN
eurjchem-885	22	7	[	[	X
eurjchem-885	22	8	17	17	NUM
eurjchem-885	22	9	]	]	PUNCT
eurjchem-885	22	10	,	,	PUNCT
eurjchem-885	22	11	micellar	micellar	ADJ
eurjchem-885	22	12	electrokinetic	electrokinetic	ADJ
eurjchem-885	22	13	chromatography	chromatography	NOUN
eurjchem-885	22	14	[	[	X
eurjchem-885	22	15	18	18	NUM
eurjchem-885	22	16	]	]	PUNCT
eurjchem-885	22	17	,	,	PUNCT
eurjchem-885	22	18	capillary	capillary	ADJ
eurjchem-885	22	19	electrophoresis	electrophoresis	NOUN
eurjchem-885	22	20	[	[	X
eurjchem-885	22	21	19,20	19,20	X
eurjchem-885	22	22	]	]	PUNCT
eurjchem-885	22	23	and	and	CCONJ
eurjchem-885	22	24	spectrophotometric	spectrophotometric	ADJ
eurjchem-885	22	25	methods	method	NOUN
eurjchem-885	22	26	[	[	X
eurjchem-885	22	27	21,22	21,22	X
eurjchem-885	22	28	]	]	X
eurjchem-885	22	29	.	.	PUNCT
eurjchem-885	23	1	in	in	ADP
eurjchem-885	23	2	reverse	reverse	ADJ
eurjchem-885	23	3	phase	phase	NOUN
eurjchem-885	23	4	high‐performance	high‐performance	NOUN
eurjchem-885	23	5	liquid	liquid	ADJ
eurjchem-885	23	6	chromatography	chromatography	NOUN
eurjchem-885	23	7	(	(	PUNCT
eurjchem-885	23	8	rp‐hplc	rp‐hplc	PROPN
eurjchem-885	23	9	)	)	PUNCT
eurjchem-885	23	10	,	,	PUNCT
eurjchem-885	23	11	each	each	DET
eurjchem-885	23	12	component	component	NOUN
eurjchem-885	23	13	interacts	interact	VERB
eurjchem-885	23	14	with	with	ADP
eurjchem-885	23	15	the	the	DET
eurjchem-885	23	16	stationary	stationary	ADJ
eurjchem-885	23	17	phase	phase	NOUN
eurjchem-885	23	18	in	in	ADP
eurjchem-885	23	19	a	a	DET
eurjchem-885	23	20	different	different	ADJ
eurjchem-885	23	21	manner	manner	NOUN
eurjchem-885	23	22	depending	depend	VERB
eurjchem-885	23	23	upon	upon	SCONJ
eurjchem-885	23	24	its	its	PRON
eurjchem-885	23	25	polarity	polarity	NOUN
eurjchem-885	23	26	and	and	CCONJ
eurjchem-885	23	27	hydro‐	hydro‐	X
eurjchem-885	23	28	phobicity	phobicity	NOUN
eurjchem-885	23	29	.	.	PUNCT
eurjchem-885	24	1	thus	thus	ADV
eurjchem-885	24	2	,	,	PUNCT
eurjchem-885	24	3	a	a	DET
eurjchem-885	24	4	separation	separation	NOUN
eurjchem-885	24	5	of	of	ADP
eurjchem-885	24	6	components	component	NOUN
eurjchem-885	24	7	is	be	AUX
eurjchem-885	24	8	achieved	achieve	VERB
eurjchem-885	24	9	based	base	VERB
eurjchem-885	24	10	on	on	ADP
eurjchem-885	24	11	polarity	polarity	NOUN
eurjchem-885	24	12	.	.	PUNCT
eurjchem-885	25	1	the	the	DET
eurjchem-885	25	2	addition	addition	NOUN
eurjchem-885	25	3	of	of	ADP
eurjchem-885	25	4	micelles	micelle	NOUN
eurjchem-885	25	5	to	to	ADP
eurjchem-885	25	6	the	the	DET
eurjchem-885	25	7	mobile	mobile	ADJ
eurjchem-885	25	8	phase	phase	NOUN
eurjchem-885	25	9	introduces	introduce	VERB
eurjchem-885	25	10	a	a	DET
eurjchem-885	25	11	third	third	ADJ
eurjchem-885	25	12	phase	phase	NOUN
eurjchem-885	25	13	into	into	ADP
eurjchem-885	25	14	which	which	PRON
eurjchem-885	25	15	the	the	DET
eurjchem-885	25	16	solutes	solute	NOUN
eurjchem-885	25	17	may	may	AUX
eurjchem-885	25	18	partition	partition	VERB
eurjchem-885	25	19	.	.	PUNCT
eurjchem-885	26	1	micellar	micellar	ADJ
eurjchem-885	26	2	liquid	liquid	ADJ
eurjchem-885	26	3	chromatography	chromatography	NOUN
eurjchem-885	26	4	(	(	PUNCT
eurjchem-885	26	5	mlc	mlc	PROPN
eurjchem-885	26	6	)	)	PUNCT
eurjchem-885	26	7	is	be	AUX
eurjchem-885	26	8	a	a	DET
eurjchem-885	26	9	form	form	NOUN
eurjchem-885	26	10	of	of	ADP
eurjchem-885	26	11	reversed	reverse	VERB
eurjchem-885	26	12	phase	phase	NOUN
eurjchem-885	26	13	liquid	liquid	ADJ
eurjchem-885	26	14	chromatography	chromatography	NOUN
eurjchem-885	26	15	that	that	PRON
eurjchem-885	26	16	uses	use	VERB
eurjchem-885	26	17	an	an	DET
eurjchem-885	26	18	aqueous	aqueous	ADJ
eurjchem-885	26	19	micellar	micellar	NOUN
eurjchem-885	26	20	solutions	solution	NOUN
eurjchem-885	26	21	as	as	ADP
eurjchem-885	26	22	the	the	DET
eurjchem-885	26	23	mobile	mobile	ADJ
eurjchem-885	26	24	phase	phase	NOUN
eurjchem-885	26	25	.	.	PUNCT
eurjchem-885	27	1	the	the	DET
eurjchem-885	27	2	use	use	NOUN
eurjchem-885	27	3	of	of	ADP
eurjchem-885	27	4	micelles	micelle	NOUN
eurjchem-885	27	5	in	in	ADP
eurjchem-885	27	6	high	high	ADJ
eurjchem-885	27	7	performance	performance	NOUN
eurjchem-885	27	8	liquid	liquid	NOUN
eurjchem-885	27	9	chromatography	chromatography	NOUN
eurjchem-885	27	10	was	be	AUX
eurjchem-885	27	11	first	first	ADV
eurjchem-885	27	12	introduced	introduce	VERB
eurjchem-885	27	13	by	by	ADP
eurjchem-885	27	14	armstrong	armstrong	PROPN
eurjchem-885	27	15	and	and	CCONJ
eurjchem-885	27	16	henry	henry	PROPN
eurjchem-885	27	17	in	in	ADP
eurjchem-885	27	18	1980	1980	NUM
eurjchem-885	27	19	[	[	X
eurjchem-885	27	20	23	23	NUM
eurjchem-885	27	21	]	]	PUNCT
eurjchem-885	27	22	.	.	PUNCT
eurjchem-885	28	1	the	the	DET
eurjchem-885	28	2	technique	technique	NOUN
eurjchem-885	28	3	is	be	AUX
eurjchem-885	28	4	used	use	VERB
eurjchem-885	28	5	mainly	mainly	ADV
eurjchem-885	28	6	to	to	PART
eurjchem-885	28	7	enhance	enhance	VERB
eurjchem-885	28	8	retention	retention	NOUN
eurjchem-885	28	9	and	and	CCONJ
eurjchem-885	28	10	selectivity	selectivity	NOUN
eurjchem-885	28	11	of	of	ADP
eurjchem-885	28	12	various	various	ADJ
eurjchem-885	28	13	solutes	solute	NOUN
eurjchem-885	28	14	that	that	PRON
eurjchem-885	28	15	would	would	AUX
eurjchem-885	28	16	otherwise	otherwise	ADV
eurjchem-885	28	17	be	be	AUX
eurjchem-885	28	18	inseparable	inseparable	ADJ
eurjchem-885	28	19	or	or	CCONJ
eurjchem-885	28	20	poorly	poorly	ADV
eurjchem-885	28	21	resolved	resolve	VERB
eurjchem-885	28	22	.	.	PUNCT
eurjchem-885	29	1	micelles	micelle	NOUN
eurjchem-885	29	2	are	be	AUX
eurjchem-885	29	3	composed	compose	VERB
eurjchem-885	29	4	of	of	ADP
eurjchem-885	29	5	surfactant	surfactant	NOUN
eurjchem-885	29	6	,	,	PUNCT
eurjchem-885	29	7	or	or	CCONJ
eurjchem-885	29	8	detergent	detergent	NOUN
eurjchem-885	29	9	,	,	PUNCT
eurjchem-885	29	10	monomers	monomer	NOUN
eurjchem-885	29	11	with	with	ADP
eurjchem-885	29	12	a	a	DET
eurjchem-885	29	13	hydrophobic	hydrophobic	ADJ
eurjchem-885	29	14	moiety	moiety	NOUN
eurjchem-885	29	15	,	,	PUNCT
eurjchem-885	29	16	or	or	CCONJ
eurjchem-885	29	17	tail	tail	NOUN
eurjchem-885	29	18	,	,	PUNCT
eurjchem-885	29	19	on	on	ADP
eurjchem-885	29	20	one	one	NUM
eurjchem-885	29	21	end	end	NOUN
eurjchem-885	29	22	,	,	PUNCT
eurjchem-885	29	23	and	and	CCONJ
eurjchem-885	29	24	a	a	DET
eurjchem-885	29	25	hydrophilic	hydrophilic	ADJ
eurjchem-885	29	26	moiety	moiety	NOUN
eurjchem-885	29	27	,	,	PUNCT
eurjchem-885	29	28	or	or	CCONJ
eurjchem-885	29	29	head	head	NOUN
eurjchem-885	29	30	group	group	NOUN
eurjchem-885	29	31	,	,	PUNCT
eurjchem-885	29	32	on	on	ADP
eurjchem-885	29	33	the	the	DET
eurjchem-885	29	34	other	other	ADJ
eurjchem-885	29	35	.	.	PUNCT
eurjchem-885	30	1	the	the	DET
eurjchem-885	30	2	polar	polar	ADJ
eurjchem-885	30	3	head	head	NOUN
eurjchem-885	30	4	group	group	NOUN
eurjchem-885	30	5	may	may	AUX
eurjchem-885	30	6	be	be	AUX
eurjchem-885	30	7	anionic	anionic	ADJ
eurjchem-885	30	8	,	,	PUNCT
eurjchem-885	30	9	cationic	cationic	ADJ
eurjchem-885	30	10	,	,	PUNCT
eurjchem-885	30	11	zwitterionic	zwitterionic	ADJ
eurjchem-885	30	12	,	,	PUNCT
eurjchem-885	30	13	or	or	CCONJ
eurjchem-885	30	14	non‐ionic	non‐ionic	ADJ
eurjchem-885	30	15	.	.	PUNCT
eurjchem-885	31	1	the	the	DET
eurjchem-885	31	2	most	most	ADV
eurjchem-885	31	3	commonly	commonly	ADV
eurjchem-885	31	4	used	use	VERB
eurjchem-885	31	5	surfactant	surfactant	NOUN
eurjchem-885	31	6	in	in	ADP
eurjchem-885	31	7	mlc	mlc	PROPN
eurjchem-885	31	8	is	be	AUX
eurjchem-885	31	9	the	the	DET
eurjchem-885	31	10	anionic	anionic	ADJ
eurjchem-885	31	11	sodium	sodium	NOUN
eurjchem-885	31	12	dodecyl	dodecyl	PROPN
eurjchem-885	31	13	sulphate	sulphate	NOUN
eurjchem-885	31	14	(	(	PUNCT
eurjchem-885	31	15	sds	sds	PROPN
eurjchem-885	31	16	)	)	PUNCT
eurjchem-885	31	17	.	.	PUNCT
eurjchem-885	32	1	when	when	SCONJ
eurjchem-885	32	2	the	the	DET
eurjchem-885	32	3	concentration	concentration	NOUN
eurjchem-885	32	4	of	of	ADP
eurjchem-885	32	5	a	a	DET
eurjchem-885	32	6	surfactant	surfactant	NOUN
eurjchem-885	32	7	12	12	NUM
eurjchem-885	32	8	rizk	rizk	PROPN
eurjchem-885	32	9	et	et	PROPN
eurjchem-885	32	10	al	al	PROPN
eurjchem-885	32	11	.	.	PUNCT
eurjchem-885	32	12	/	/	SYM
eurjchem-885	32	13	european	european	PROPN
eurjchem-885	32	14	journal	journal	PROPN
eurjchem-885	32	15	of	of	ADP
eurjchem-885	32	16	chemistry	chemistry	NOUN
eurjchem-885	32	17	5	5	NUM
eurjchem-885	32	18	(	(	PUNCT
eurjchem-885	32	19	1	1	NUM
eurjchem-885	32	20	)	)	PUNCT
eurjchem-885	32	21	(	(	PUNCT
eurjchem-885	32	22	2014	2014	NUM
eurjchem-885	32	23	)	)	PUNCT
eurjchem-885	32	24	11‐17	11‐17	NOUN
eurjchem-885	32	25	in	in	ADP
eurjchem-885	32	26	solution	solution	NOUN
eurjchem-885	32	27	reaches	reach	VERB
eurjchem-885	32	28	its	its	PRON
eurjchem-885	32	29	critical	critical	ADJ
eurjchem-885	32	30	micelle	micelle	NOUN
eurjchem-885	32	31	concentration	concentration	NOUN
eurjchem-885	32	32	(	(	PUNCT
eurjchem-885	32	33	cmc	cmc	PROPN
eurjchem-885	32	34	)	)	PUNCT
eurjchem-885	32	35	,	,	PUNCT
eurjchem-885	32	36	it	it	PRON
eurjchem-885	32	37	forms	form	VERB
eurjchem-885	32	38	micelles	micelle	NOUN
eurjchem-885	32	39	which	which	PRON
eurjchem-885	32	40	are	be	AUX
eurjchem-885	32	41	aggregates	aggregate	NOUN
eurjchem-885	32	42	of	of	ADP
eurjchem-885	32	43	the	the	DET
eurjchem-885	32	44	monomers	monomer	NOUN
eurjchem-885	32	45	.	.	PUNCT
eurjchem-885	33	1	the	the	DET
eurjchem-885	33	2	cmc	cmc	NOUN
eurjchem-885	33	3	is	be	AUX
eurjchem-885	33	4	different	different	ADJ
eurjchem-885	33	5	for	for	ADP
eurjchem-885	33	6	each	each	DET
eurjchem-885	33	7	surfactant	surfactant	NOUN
eurjchem-885	33	8	,	,	PUNCT
eurjchem-885	33	9	as	as	SCONJ
eurjchem-885	33	10	is	be	AUX
eurjchem-885	33	11	the	the	DET
eurjchem-885	33	12	number	number	NOUN
eurjchem-885	33	13	of	of	ADP
eurjchem-885	33	14	monomers	monomer	NOUN
eurjchem-885	33	15	which	which	PRON
eurjchem-885	33	16	make	make	VERB
eurjchem-885	33	17	up	up	ADP
eurjchem-885	33	18	the	the	DET
eurjchem-885	33	19	micelle	micelle	NOUN
eurjchem-885	33	20	,	,	PUNCT
eurjchem-885	33	21	termed	term	VERB
eurjchem-885	33	22	the	the	DET
eurjchem-885	33	23	aggregation	aggregation	NOUN
eurjchem-885	33	24	number	number	NOUN
eurjchem-885	33	25	(	(	PUNCT
eurjchem-885	33	26	an	an	NOUN
eurjchem-885	33	27	)	)	PUNCT
eurjchem-885	33	28	.	.	PUNCT
eurjchem-885	34	1	in	in	ADP
eurjchem-885	34	2	mlc	mlc	PROPN
eurjchem-885	34	3	,	,	PUNCT
eurjchem-885	34	4	there	there	PRON
eurjchem-885	34	5	are	be	VERB
eurjchem-885	34	6	three	three	NUM
eurjchem-885	34	7	partition	partition	NOUN
eurjchem-885	34	8	coefficients	coefficient	NOUN
eurjchem-885	34	9	which	which	PRON
eurjchem-885	34	10	must	must	AUX
eurjchem-885	34	11	be	be	AUX
eurjchem-885	34	12	taken	take	VERB
eurjchem-885	34	13	into	into	ADP
eurjchem-885	34	14	account	account	NOUN
eurjchem-885	34	15	.	.	PUNCT
eurjchem-885	35	1	the	the	DET
eurjchem-885	35	2	solute	solute	NOUN
eurjchem-885	35	3	will	will	AUX
eurjchem-885	35	4	partition	partition	VERB
eurjchem-885	35	5	between	between	ADP
eurjchem-885	35	6	the	the	DET
eurjchem-885	35	7	water	water	NOUN
eurjchem-885	35	8	and	and	CCONJ
eurjchem-885	35	9	the	the	DET
eurjchem-885	35	10	stationary	stationary	ADJ
eurjchem-885	35	11	phase	phase	NOUN
eurjchem-885	35	12	,	,	PUNCT
eurjchem-885	35	13	the	the	DET
eurjchem-885	35	14	water	water	NOUN
eurjchem-885	35	15	and	and	CCONJ
eurjchem-885	35	16	the	the	DET
eurjchem-885	35	17	micelles	micelle	NOUN
eurjchem-885	35	18	,	,	PUNCT
eurjchem-885	35	19	and	and	CCONJ
eurjchem-885	35	20	the	the	DET
eurjchem-885	35	21	micelles	micelle	NOUN
eurjchem-885	35	22	and	and	CCONJ
eurjchem-885	35	23	the	the	DET
eurjchem-885	35	24	stationary	stationary	ADJ
eurjchem-885	35	25	phase	phase	NOUN
eurjchem-885	35	26	,	,	PUNCT
eurjchem-885	35	27	so	so	ADV
eurjchem-885	35	28	gives	give	VERB
eurjchem-885	35	29	a	a	DET
eurjchem-885	35	30	large	large	ADJ
eurjchem-885	35	31	versatility	versatility	NOUN
eurjchem-885	35	32	to	to	ADP
eurjchem-885	35	33	this	this	DET
eurjchem-885	35	34	technique	technique	NOUN
eurjchem-885	35	35	and	and	CCONJ
eurjchem-885	35	36	make	make	VERB
eurjchem-885	35	37	it	it	PRON
eurjchem-885	35	38	appropriate	appropriate	ADJ
eurjchem-885	35	39	for	for	ADP
eurjchem-885	35	40	a	a	DET
eurjchem-885	35	41	wide	wide	ADJ
eurjchem-885	35	42	range	range	NOUN
eurjchem-885	35	43	of	of	ADP
eurjchem-885	35	44	solutes	solute	NOUN
eurjchem-885	35	45	that	that	PRON
eurjchem-885	35	46	can	can	AUX
eurjchem-885	35	47	be	be	AUX
eurjchem-885	35	48	separated	separate	VERB
eurjchem-885	35	49	in	in	ADP
eurjchem-885	35	50	one	one	NUM
eurjchem-885	35	51	run	run	NOUN
eurjchem-885	35	52	.	.	PUNCT
eurjchem-885	36	1	many	many	ADJ
eurjchem-885	36	2	of	of	ADP
eurjchem-885	36	3	the	the	DET
eurjchem-885	36	4	characteristics	characteristic	NOUN
eurjchem-885	36	5	of	of	ADP
eurjchem-885	36	6	micelles	micelle	NOUN
eurjchem-885	36	7	differ	differ	VERB
eurjchem-885	36	8	from	from	ADP
eurjchem-885	36	9	those	those	PRON
eurjchem-885	36	10	of	of	ADP
eurjchem-885	36	11	bulk	bulk	ADJ
eurjchem-885	36	12	solvents	solvent	NOUN
eurjchem-885	36	13	.	.	PUNCT
eurjchem-885	37	1	for	for	ADP
eurjchem-885	37	2	example	example	NOUN
eurjchem-885	37	3	,	,	PUNCT
eurjchem-885	37	4	the	the	DET
eurjchem-885	37	5	micelles	micelle	NOUN
eurjchem-885	37	6	are	be	AUX
eurjchem-885	37	7	,	,	PUNCT
eurjchem-885	37	8	by	by	ADP
eurjchem-885	37	9	nature	nature	NOUN
eurjchem-885	37	10	,	,	PUNCT
eurjchem-885	37	11	spatially	spatially	ADV
eurjchem-885	37	12	heterogeneous	heterogeneous	ADJ
eurjchem-885	37	13	with	with	ADP
eurjchem-885	37	14	a	a	DET
eurjchem-885	37	15	hydrocarbon	hydrocarbon	NOUN
eurjchem-885	37	16	,	,	PUNCT
eurjchem-885	37	17	nearly	nearly	ADV
eurjchem-885	37	18	anhydrous	anhydrous	ADJ
eurjchem-885	37	19	core	core	NOUN
eurjchem-885	37	20	and	and	CCONJ
eurjchem-885	37	21	a	a	DET
eurjchem-885	37	22	highly	highly	ADV
eurjchem-885	37	23	solvated	solvate	VERB
eurjchem-885	37	24	,	,	PUNCT
eurjchem-885	37	25	polar	polar	ADJ
eurjchem-885	37	26	head	head	NOUN
eurjchem-885	37	27	group	group	NOUN
eurjchem-885	37	28	.	.	PUNCT
eurjchem-885	38	1	they	they	PRON
eurjchem-885	38	2	have	have	VERB
eurjchem-885	38	3	a	a	DET
eurjchem-885	38	4	high	high	ADJ
eurjchem-885	38	5	surface‐	surface‐	NOUN
eurjchem-885	38	6	to‐volume	to‐volume	NOUN
eurjchem-885	38	7	ratio	ratio	NOUN
eurjchem-885	38	8	due	due	ADP
eurjchem-885	38	9	to	to	ADP
eurjchem-885	38	10	their	their	PRON
eurjchem-885	38	11	small	small	ADJ
eurjchem-885	38	12	size	size	NOUN
eurjchem-885	38	13	and	and	CCONJ
eurjchem-885	38	14	generally	generally	ADV
eurjchem-885	38	15	spherical	spherical	ADJ
eurjchem-885	38	16	shape	shape	NOUN
eurjchem-885	38	17	.	.	PUNCT
eurjchem-885	39	1	their	their	PRON
eurjchem-885	39	2	surrounding	surround	VERB
eurjchem-885	39	3	environment	environment	NOUN
eurjchem-885	39	4	(	(	PUNCT
eurjchem-885	39	5	ph	ph	ADJ
eurjchem-885	39	6	,	,	PUNCT
eurjchem-885	39	7	ionic	ionic	ADJ
eurjchem-885	39	8	strength	strength	NOUN
eurjchem-885	39	9	,	,	PUNCT
eurjchem-885	39	10	buffer	buffer	NOUN
eurjchem-885	39	11	ion	ion	NOUN
eurjchem-885	39	12	,	,	PUNCT
eurjchem-885	39	13	presence	presence	NOUN
eurjchem-885	39	14	of	of	ADP
eurjchem-885	39	15	a	a	DET
eurjchem-885	39	16	co‐solvent	co‐solvent	ADJ
eurjchem-885	39	17	,	,	PUNCT
eurjchem-885	39	18	and	and	CCONJ
eurjchem-885	39	19	temperature	temperature	NOUN
eurjchem-885	39	20	)	)	PUNCT
eurjchem-885	39	21	has	have	VERB
eurjchem-885	39	22	an	an	DET
eurjchem-885	39	23	influence	influence	NOUN
eurjchem-885	39	24	on	on	ADP
eurjchem-885	39	25	their	their	PRON
eurjchem-885	39	26	size	size	NOUN
eurjchem-885	39	27	,	,	PUNCT
eurjchem-885	39	28	shape	shape	NOUN
eurjchem-885	39	29	,	,	PUNCT
eurjchem-885	39	30	critical	critical	ADJ
eurjchem-885	39	31	micelle	micelle	NOUN
eurjchem-885	39	32	concentration	concentration	NOUN
eurjchem-885	39	33	,	,	PUNCT
eurjchem-885	39	34	aggregation	aggregation	NOUN
eurjchem-885	39	35	number	number	NOUN
eurjchem-885	39	36	and	and	CCONJ
eurjchem-885	39	37	other	other	ADJ
eurjchem-885	39	38	properties	property	NOUN
eurjchem-885	39	39	.	.	PUNCT
eurjchem-885	40	1	the	the	DET
eurjchem-885	40	2	main	main	ADJ
eurjchem-885	40	3	limitation	limitation	NOUN
eurjchem-885	40	4	in	in	ADP
eurjchem-885	40	5	the	the	DET
eurjchem-885	40	6	use	use	NOUN
eurjchem-885	40	7	of	of	ADP
eurjchem-885	40	8	mlc	mlc	NOUN
eurjchem-885	40	9	is	be	AUX
eurjchem-885	40	10	the	the	DET
eurjchem-885	40	11	reduction	reduction	NOUN
eurjchem-885	40	12	in	in	ADP
eurjchem-885	40	13	efficiency	efficiency	NOUN
eurjchem-885	40	14	(	(	PUNCT
eurjchem-885	40	15	peak	peak	NOUN
eurjchem-885	40	16	broadening	broadening	NOUN
eurjchem-885	40	17	)	)	PUNCT
eurjchem-885	40	18	that	that	PRON
eurjchem-885	40	19	is	be	AUX
eurjchem-885	40	20	observed	observe	VERB
eurjchem-885	40	21	when	when	SCONJ
eurjchem-885	40	22	purely	purely	ADV
eurjchem-885	40	23	aqueous	aqueous	ADJ
eurjchem-885	40	24	micellar	micellar	ADJ
eurjchem-885	40	25	mobile	mobile	ADJ
eurjchem-885	40	26	phases	phase	NOUN
eurjchem-885	40	27	are	be	AUX
eurjchem-885	40	28	used	use	VERB
eurjchem-885	40	29	[	[	PUNCT
eurjchem-885	40	30	24	24	NUM
eurjchem-885	40	31	]	]	PUNCT
eurjchem-885	40	32	.	.	PUNCT
eurjchem-885	41	1	several	several	ADJ
eurjchem-885	41	2	explanations	explanation	NOUN
eurjchem-885	41	3	for	for	ADP
eurjchem-885	41	4	the	the	DET
eurjchem-885	41	5	poor	poor	ADJ
eurjchem-885	41	6	efficiency	efficiency	NOUN
eurjchem-885	41	7	have	have	AUX
eurjchem-885	41	8	been	be	AUX
eurjchem-885	41	9	theorized	theorize	VERB
eurjchem-885	41	10	.	.	PUNCT
eurjchem-885	42	1	poor	poor	ADJ
eurjchem-885	42	2	wetting	wetting	NOUN
eurjchem-885	42	3	of	of	ADP
eurjchem-885	42	4	the	the	DET
eurjchem-885	42	5	stationary	stationary	ADJ
eurjchem-885	42	6	phase	phase	NOUN
eurjchem-885	42	7	by	by	ADP
eurjchem-885	42	8	the	the	DET
eurjchem-885	42	9	micellar	micellar	ADJ
eurjchem-885	42	10	aqueous	aqueous	ADJ
eurjchem-885	42	11	mobile	mobile	NOUN
eurjchem-885	42	12	phase	phase	NOUN
eurjchem-885	42	13	,	,	PUNCT
eurjchem-885	42	14	slow	slow	ADJ
eurjchem-885	42	15	mass	mass	NOUN
eurjchem-885	42	16	transfer	transfer	NOUN
eurjchem-885	42	17	between	between	ADP
eurjchem-885	42	18	the	the	DET
eurjchem-885	42	19	micelles	micelle	NOUN
eurjchem-885	42	20	and	and	CCONJ
eurjchem-885	42	21	the	the	DET
eurjchem-885	42	22	stationary	stationary	ADJ
eurjchem-885	42	23	phase	phase	NOUN
eurjchem-885	42	24	,	,	PUNCT
eurjchem-885	42	25	and	and	CCONJ
eurjchem-885	42	26	poor	poor	ADJ
eurjchem-885	42	27	mass	mass	NOUN
eurjchem-885	42	28	transfer	transfer	NOUN
eurjchem-885	42	29	within	within	ADP
eurjchem-885	42	30	the	the	DET
eurjchem-885	42	31	stationary	stationary	ADJ
eurjchem-885	42	32	phase	phase	NOUN
eurjchem-885	42	33	have	have	AUX
eurjchem-885	42	34	all	all	PRON
eurjchem-885	42	35	been	be	AUX
eurjchem-885	42	36	postulated	postulate	VERB
eurjchem-885	42	37	as	as	ADP
eurjchem-885	42	38	possible	possible	ADJ
eurjchem-885	42	39	causes	cause	NOUN
eurjchem-885	42	40	.	.	PUNCT
eurjchem-885	43	1	to	to	PART
eurjchem-885	43	2	enhance	enhance	VERB
eurjchem-885	43	3	efficiency	efficiency	NOUN
eurjchem-885	43	4	,	,	PUNCT
eurjchem-885	43	5	the	the	DET
eurjchem-885	43	6	most	most	ADV
eurjchem-885	43	7	common	common	ADJ
eurjchem-885	43	8	approaches	approach	NOUN
eurjchem-885	43	9	have	have	AUX
eurjchem-885	43	10	been	be	AUX
eurjchem-885	43	11	the	the	DET
eurjchem-885	43	12	addition	addition	NOUN
eurjchem-885	43	13	of	of	ADP
eurjchem-885	43	14	small	small	ADJ
eurjchem-885	43	15	amounts	amount	NOUN
eurjchem-885	43	16	of	of	ADP
eurjchem-885	43	17	organic	organic	ADJ
eurjchem-885	43	18	modifiers	modifier	NOUN
eurjchem-885	43	19	,	,	PUNCT
eurjchem-885	43	20	particularly	particularly	ADV
eurjchem-885	43	21	alcohol	alcohol	NOUN
eurjchem-885	43	22	,	,	PUNCT
eurjchem-885	43	23	and	and	CCONJ
eurjchem-885	43	24	increasing	increase	VERB
eurjchem-885	43	25	the	the	DET
eurjchem-885	43	26	column	column	NOUN
eurjchem-885	43	27	temperature	temperature	NOUN
eurjchem-885	43	28	.	.	PUNCT
eurjchem-885	44	1	care	care	NOUN
eurjchem-885	44	2	needs	need	VERB
eurjchem-885	44	3	to	to	PART
eurjchem-885	44	4	be	be	AUX
eurjchem-885	44	5	taken	take	VERB
eurjchem-885	44	6	when	when	SCONJ
eurjchem-885	44	7	determining	determine	VERB
eurjchem-885	44	8	how	how	SCONJ
eurjchem-885	44	9	much	much	ADJ
eurjchem-885	44	10	organic	organic	ADJ
eurjchem-885	44	11	to	to	PART
eurjchem-885	44	12	add	add	VERB
eurjchem-885	44	13	.	.	PUNCT
eurjchem-885	45	1	too	too	ADV
eurjchem-885	45	2	high	high	ADJ
eurjchem-885	45	3	a	a	DET
eurjchem-885	45	4	concentration	concentration	NOUN
eurjchem-885	45	5	of	of	ADP
eurjchem-885	45	6	the	the	DET
eurjchem-885	45	7	organic	organic	NOUN
eurjchem-885	45	8	may	may	AUX
eurjchem-885	45	9	cause	cause	VERB
eurjchem-885	45	10	the	the	DET
eurjchem-885	45	11	micelle	micelle	NOUN
eurjchem-885	45	12	to	to	PART
eurjchem-885	45	13	disperse	disperse	VERB
eurjchem-885	45	14	,	,	PUNCT
eurjchem-885	45	15	but	but	CCONJ
eurjchem-885	45	16	a	a	DET
eurjchem-885	45	17	generally	generally	ADV
eurjchem-885	45	18	accepted	accept	VERB
eurjchem-885	45	19	practice	practice	NOUN
eurjchem-885	45	20	is	be	AUX
eurjchem-885	45	21	to	to	PART
eurjchem-885	45	22	keep	keep	VERB
eurjchem-885	45	23	the	the	DET
eurjchem-885	45	24	volume	volume	NOUN
eurjchem-885	45	25	percentage	percentage	NOUN
eurjchem-885	45	26	of	of	ADP
eurjchem-885	45	27	organic	organic	ADJ
eurjchem-885	45	28	below	below	ADP
eurjchem-885	45	29	15‐20	15‐20	NUM
eurjchem-885	45	30	%	%	NOUN
eurjchem-885	45	31	.	.	PUNCT
eurjchem-885	46	1	despite	despite	SCONJ
eurjchem-885	46	2	the	the	DET
eurjchem-885	46	3	reduced	reduce	VERB
eurjchem-885	46	4	efficiency	efficiency	NOUN
eurjchem-885	46	5	verses	verses	ADP
eurjchem-885	46	6	rp‐hplc	rp‐hplc	PROPN
eurjchem-885	46	7	,	,	PUNCT
eurjchem-885	46	8	hundreds	hundred	NOUN
eurjchem-885	46	9	of	of	ADP
eurjchem-885	46	10	applications	application	NOUN
eurjchem-885	46	11	have	have	AUX
eurjchem-885	46	12	been	be	AUX
eurjchem-885	46	13	reported	report	VERB
eurjchem-885	46	14	using	use	VERB
eurjchem-885	46	15	mlc	mlc	NOUN
eurjchem-885	46	16	.	.	PUNCT
eurjchem-885	47	1	one	one	NUM
eurjchem-885	47	2	of	of	ADP
eurjchem-885	47	3	the	the	DET
eurjchem-885	47	4	most	most	ADV
eurjchem-885	47	5	advantageous	advantageous	ADJ
eurjchem-885	47	6	is	be	AUX
eurjchem-885	47	7	the	the	DET
eurjchem-885	47	8	ability	ability	NOUN
eurjchem-885	47	9	to	to	PART
eurjchem-885	47	10	directly	directly	ADV
eurjchem-885	47	11	inject	inject	VERB
eurjchem-885	47	12	physiological	physiological	ADJ
eurjchem-885	47	13	fluids	fluid	NOUN
eurjchem-885	47	14	.	.	PUNCT
eurjchem-885	48	1	micelles	micelle	NOUN
eurjchem-885	48	2	have	have	VERB
eurjchem-885	48	3	an	an	DET
eurjchem-885	48	4	ability	ability	NOUN
eurjchem-885	48	5	to	to	PART
eurjchem-885	48	6	solubilize	solubilize	VERB
eurjchem-885	48	7	proteins	protein	NOUN
eurjchem-885	48	8	which	which	PRON
eurjchem-885	48	9	enables	enable	VERB
eurjchem-885	48	10	mlc	mlc	NOUN
eurjchem-885	48	11	to	to	PART
eurjchem-885	48	12	be	be	AUX
eurjchem-885	48	13	useful	useful	ADJ
eurjchem-885	48	14	in	in	ADP
eurjchem-885	48	15	analyzing	analyze	VERB
eurjchem-885	48	16	untreated	untreated	ADJ
eurjchem-885	48	17	biological	biological	ADJ
eurjchem-885	48	18	fluids	fluid	NOUN
eurjchem-885	48	19	such	such	ADJ
eurjchem-885	48	20	as	as	ADP
eurjchem-885	48	21	plasma	plasma	NOUN
eurjchem-885	48	22	,	,	PUNCT
eurjchem-885	48	23	serum	serum	NOUN
eurjchem-885	48	24	,	,	PUNCT
eurjchem-885	48	25	and	and	CCONJ
eurjchem-885	48	26	urine	urine	NOUN
eurjchem-885	48	27	.	.	PUNCT
eurjchem-885	49	1	mlc	mlc	PROPN
eurjchem-885	49	2	is	be	AUX
eurjchem-885	49	3	a	a	DET
eurjchem-885	49	4	better	well	ADJ
eurjchem-885	49	5	choice	choice	NOUN
eurjchem-885	49	6	than	than	ADP
eurjchem-885	49	7	ion‐exchange	ion‐exchange	NOUN
eurjchem-885	49	8	lc	lc	NOUN
eurjchem-885	49	9	or	or	CCONJ
eurjchem-885	49	10	ion‐pairing	ion‐paire	VERB
eurjchem-885	49	11	lc	lc	NOUN
eurjchem-885	49	12	for	for	ADP
eurjchem-885	49	13	separation	separation	NOUN
eurjchem-885	49	14	of	of	ADP
eurjchem-885	49	15	charged	charge	VERB
eurjchem-885	49	16	molecules	molecule	NOUN
eurjchem-885	49	17	and	and	CCONJ
eurjchem-885	49	18	mixtures	mixture	NOUN
eurjchem-885	49	19	of	of	ADP
eurjchem-885	49	20	charged	charge	VERB
eurjchem-885	49	21	and	and	CCONJ
eurjchem-885	49	22	neutral	neutral	ADJ
eurjchem-885	49	23	species	specie	NOUN
eurjchem-885	49	24	.	.	PUNCT
eurjchem-885	50	1	analysis	analysis	NOUN
eurjchem-885	50	2	of	of	ADP
eurjchem-885	50	3	pharmaceuticals	pharmaceutical	NOUN
eurjchem-885	50	4	by	by	ADP
eurjchem-885	50	5	mlc	mlc	PROPN
eurjchem-885	50	6	is	be	AUX
eurjchem-885	50	7	also	also	ADV
eurjchem-885	50	8	gaining	gain	VERB
eurjchem-885	50	9	popularity	popularity	NOUN
eurjchem-885	50	10	.	.	PUNCT
eurjchem-885	51	1	another	another	DET
eurjchem-885	51	2	novel	novel	ADJ
eurjchem-885	51	3	application	application	NOUN
eurjchem-885	51	4	of	of	ADP
eurjchem-885	51	5	mlc	mlc	PROPN
eurjchem-885	51	6	involves	involve	VERB
eurjchem-885	51	7	the	the	DET
eurjchem-885	51	8	separation	separation	NOUN
eurjchem-885	51	9	and	and	CCONJ
eurjchem-885	51	10	analysis	analysis	NOUN
eurjchem-885	51	11	of	of	ADP
eurjchem-885	51	12	inorganic	inorganic	ADJ
eurjchem-885	51	13	compounds	compound	NOUN
eurjchem-885	51	14	,	,	PUNCT
eurjchem-885	51	15	mostly	mostly	ADV
eurjchem-885	51	16	simple	simple	ADJ
eurjchem-885	51	17	ions	ion	NOUN
eurjchem-885	51	18	.	.	PUNCT
eurjchem-885	52	1	this	this	PRON
eurjchem-885	52	2	is	be	AUX
eurjchem-885	52	3	a	a	DET
eurjchem-885	52	4	relatively	relatively	ADV
eurjchem-885	52	5	new	new	ADJ
eurjchem-885	52	6	area	area	NOUN
eurjchem-885	52	7	for	for	ADP
eurjchem-885	52	8	mlc	mlc	NOUN
eurjchem-885	52	9	.	.	PUNCT
eurjchem-885	53	1	the	the	DET
eurjchem-885	53	2	aim	aim	NOUN
eurjchem-885	53	3	of	of	ADP
eurjchem-885	53	4	this	this	DET
eurjchem-885	53	5	work	work	NOUN
eurjchem-885	53	6	is	be	AUX
eurjchem-885	53	7	to	to	PART
eurjchem-885	53	8	perform	perform	VERB
eurjchem-885	53	9	more	more	ADV
eurjchem-885	53	10	accurate	accurate	ADJ
eurjchem-885	53	11	,	,	PUNCT
eurjchem-885	53	12	reliable	reliable	ADJ
eurjchem-885	53	13	,	,	PUNCT
eurjchem-885	53	14	fast	fast	ADJ
eurjchem-885	53	15	and	and	CCONJ
eurjchem-885	53	16	validated	validated	ADJ
eurjchem-885	53	17	mlc	mlc	NOUN
eurjchem-885	53	18	method	method	NOUN
eurjchem-885	53	19	for	for	ADP
eurjchem-885	53	20	determination	determination	NOUN
eurjchem-885	53	21	of	of	ADP
eurjchem-885	53	22	itc	itc	PROPN
eurjchem-885	53	23	in	in	ADP
eurjchem-885	53	24	bulk	bulk	NOUN
eurjchem-885	53	25	,	,	PUNCT
eurjchem-885	53	26	dosage	dosage	NOUN
eurjchem-885	53	27	form	form	NOUN
eurjchem-885	53	28	and	and	CCONJ
eurjchem-885	53	29	spiked	spiked	ADJ
eurjchem-885	53	30	human	human	ADJ
eurjchem-885	53	31	plasma	plasma	NOUN
eurjchem-885	53	32	with	with	ADP
eurjchem-885	53	33	a	a	DET
eurjchem-885	53	34	simple	simple	ADJ
eurjchem-885	53	35	and	and	CCONJ
eurjchem-885	53	36	rapid	rapid	ADJ
eurjchem-885	53	37	sample	sample	NOUN
eurjchem-885	53	38	preparation	preparation	NOUN
eurjchem-885	53	39	especially	especially	ADV
eurjchem-885	53	40	for	for	ADP
eurjchem-885	53	41	the	the	DET
eurjchem-885	53	42	routine	routine	ADJ
eurjchem-885	53	43	analysis	analysis	NOUN
eurjchem-885	53	44	.	.	PUNCT
eurjchem-885	54	1	different	different	ADJ
eurjchem-885	54	2	chromatographic	chromatographic	ADJ
eurjchem-885	54	3	parameters	parameter	NOUN
eurjchem-885	54	4	were	be	AUX
eurjchem-885	54	5	investigated	investigate	VERB
eurjchem-885	54	6	to	to	PART
eurjchem-885	54	7	select	select	VERB
eurjchem-885	54	8	the	the	DET
eurjchem-885	54	9	optimum	optimum	ADJ
eurjchem-885	54	10	conditions	condition	NOUN
eurjchem-885	54	11	for	for	ADP
eurjchem-885	54	12	the	the	DET
eurjchem-885	54	13	separation	separation	NOUN
eurjchem-885	54	14	and	and	CCONJ
eurjchem-885	54	15	for	for	ADP
eurjchem-885	54	16	applying	apply	VERB
eurjchem-885	54	17	as	as	ADP
eurjchem-885	54	18	stability‐indicating	stability‐indicate	VERB
eurjchem-885	54	19	method	method	NOUN
eurjchem-885	54	20	for	for	ADP
eurjchem-885	54	21	determination	determination	NOUN
eurjchem-885	54	22	itc	itc	PROPN
eurjchem-885	54	23	under	under	ADP
eurjchem-885	54	24	different	different	ADJ
eurjchem-885	54	25	stress	stress	NOUN
eurjchem-885	54	26	conditions	condition	NOUN
eurjchem-885	54	27	.	.	PUNCT
eurjchem-885	55	1	the	the	DET
eurjchem-885	55	2	result	result	NOUN
eurjchem-885	55	3	obtained	obtain	VERB
eurjchem-885	55	4	by	by	ADP
eurjchem-885	55	5	the	the	DET
eurjchem-885	55	6	proposed	propose	VERB
eurjchem-885	55	7	method	method	NOUN
eurjchem-885	55	8	was	be	AUX
eurjchem-885	55	9	compared	compare	VERB
eurjchem-885	55	10	with	with	ADP
eurjchem-885	55	11	that	that	PRON
eurjchem-885	55	12	obtained	obtain	VERB
eurjchem-885	55	13	by	by	ADP
eurjchem-885	55	14	the	the	DET
eurjchem-885	55	15	hplc	hplc	NOUN
eurjchem-885	55	16	technique	technique	NOUN
eurjchem-885	55	17	[	[	X
eurjchem-885	55	18	2	2	NUM
eurjchem-885	55	19	]	]	PUNCT
eurjchem-885	55	20	.	.	PUNCT
eurjchem-885	56	1	the	the	DET
eurjchem-885	56	2	method	method	NOUN
eurjchem-885	56	3	was	be	AUX
eurjchem-885	56	4	validated	validate	VERB
eurjchem-885	56	5	according	accord	VERB
eurjchem-885	56	6	to	to	ADP
eurjchem-885	56	7	the	the	DET
eurjchem-885	56	8	international	international	ADJ
eurjchem-885	56	9	conference	conference	NOUN
eurjchem-885	56	10	on	on	ADP
eurjchem-885	56	11	harmonization	harmonization	NOUN
eurjchem-885	56	12	guidelines	guideline	NOUN
eurjchem-885	56	13	(	(	PUNCT
eurjchem-885	56	14	ich	ich	NOUN
eurjchem-885	56	15	)	)	PUNCT
eurjchem-885	57	1	[	[	X
eurjchem-885	57	2	25	25	NUM
eurjchem-885	57	3	]	]	PUNCT
eurjchem-885	57	4	.	.	PUNCT
eurjchem-885	58	1	2	2	X
eurjchem-885	58	2	.	.	X
eurjchem-885	58	3	experimental	experimental	ADJ
eurjchem-885	58	4	2.1	2.1	NUM
eurjchem-885	58	5	.	.	PUNCT
eurjchem-885	59	1	materials	material	NOUN
eurjchem-885	59	2	itc	itc	NOUN
eurjchem-885	59	3	(	(	PUNCT
eurjchem-885	59	4	99.9	99.9	NUM
eurjchem-885	59	5	%	%	NOUN
eurjchem-885	59	6	purity	purity	NOUN
eurjchem-885	59	7	)	)	PUNCT
eurjchem-885	59	8	was	be	AUX
eurjchem-885	59	9	kindly	kindly	ADV
eurjchem-885	59	10	supplied	supply	VERB
eurjchem-885	59	11	by	by	ADP
eurjchem-885	59	12	multiapex	multiapex	NOUN
eurjchem-885	59	13	pharma	pharma	PROPN
eurjchem-885	59	14	drug	drug	NOUN
eurjchem-885	59	15	company	company	NOUN
eurjchem-885	59	16	(	(	PUNCT
eurjchem-885	59	17	egypt	egypt	PROPN
eurjchem-885	59	18	)	)	PUNCT
eurjchem-885	59	19	.	.	PUNCT
eurjchem-885	60	1	the	the	DET
eurjchem-885	60	2	pharmaceutical	pharmaceutical	ADJ
eurjchem-885	60	3	products	product	NOUN
eurjchem-885	60	4	used	use	VERB
eurjchem-885	60	5	were	be	AUX
eurjchem-885	60	6	(	(	PUNCT
eurjchem-885	60	7	1	1	X
eurjchem-885	60	8	)	)	PUNCT
eurjchem-885	60	9	itrapex	itrapex	NOUN
eurjchem-885	60	10	capsules	capsule	NOUN
eurjchem-885	60	11	(	(	PUNCT
eurjchem-885	60	12	apex	apex	PROPN
eurjchem-885	60	13	pharma	pharma	PROPN
eurjchem-885	60	14	co.	co.	PROPN
eurjchem-885	60	15	,	,	PUNCT
eurjchem-885	60	16	egypt	egypt	PROPN
eurjchem-885	60	17	)	)	PUNCT
eurjchem-885	60	18	,	,	PUNCT
eurjchem-885	60	19	(	(	PUNCT
eurjchem-885	60	20	2	2	X
eurjchem-885	60	21	)	)	PUNCT
eurjchem-885	60	22	itracon	itracon	ADJ
eurjchem-885	60	23	capsules	capsule	NOUN
eurjchem-885	60	24	(	(	PUNCT
eurjchem-885	60	25	global	global	ADJ
eurjchem-885	60	26	napi	napi	PROPN
eurjchem-885	60	27	pharmaceuticals	pharmaceuticals	PROPN
eurjchem-885	60	28	co.	co.	PROPN
eurjchem-885	60	29	,	,	PUNCT
eurjchem-885	60	30	egypt	egypt	PROPN
eurjchem-885	60	31	)	)	PUNCT
eurjchem-885	60	32	,	,	PUNCT
eurjchem-885	60	33	(	(	PUNCT
eurjchem-885	60	34	3	3	X
eurjchem-885	60	35	)	)	PUNCT
eurjchem-885	60	36	itranox	itranox	NOUN
eurjchem-885	60	37	capsules	capsule	NOUN
eurjchem-885	60	38	(	(	PUNCT
eurjchem-885	60	39	adwia	adwia	PROPN
eurjchem-885	60	40	pharmaceutical	pharmaceutical	PROPN
eurjchem-885	60	41	co.	co.	PROPN
eurjchem-885	60	42	,	,	PUNCT
eurjchem-885	60	43	egypt	egypt	PROPN
eurjchem-885	60	44	)	)	PUNCT
eurjchem-885	60	45	.	.	PUNCT
eurjchem-885	61	1	all	all	DET
eurjchem-885	61	2	drugs	drug	NOUN
eurjchem-885	61	3	contain	contain	VERB
eurjchem-885	61	4	100	100	NUM
eurjchem-885	61	5	mg	mg	PROPN
eurjchem-885	61	6	itc	itc	PROPN
eurjchem-885	61	7	/	/	SYM
eurjchem-885	61	8	capsule	capsule	PROPN
eurjchem-885	61	9	.	.	PUNCT
eurjchem-885	62	1	they	they	PRON
eurjchem-885	62	2	were	be	AUX
eurjchem-885	62	3	obtained	obtain	VERB
eurjchem-885	62	4	from	from	ADP
eurjchem-885	62	5	local	local	ADJ
eurjchem-885	62	6	pharmacies	pharmacy	NOUN
eurjchem-885	62	7	.	.	PUNCT
eurjchem-885	63	1	plasma	plasma	NOUN
eurjchem-885	63	2	samples	sample	NOUN
eurjchem-885	63	3	were	be	AUX
eurjchem-885	63	4	obtained	obtain	VERB
eurjchem-885	63	5	from	from	ADP
eurjchem-885	63	6	egyptian	egyptian	ADJ
eurjchem-885	63	7	research	research	PROPN
eurjchem-885	63	8	and	and	CCONJ
eurjchem-885	63	9	development	development	NOUN
eurjchem-885	63	10	company	company	NOUN
eurjchem-885	63	11	and	and	CCONJ
eurjchem-885	63	12	kept	keep	VERB
eurjchem-885	63	13	frozen	freeze	VERB
eurjchem-885	63	14	until	until	ADP
eurjchem-885	63	15	using	use	VERB
eurjchem-885	63	16	after	after	ADP
eurjchem-885	63	17	gentle	gentle	ADJ
eurjchem-885	63	18	thawing	thawing	NOUN
eurjchem-885	63	19	.	.	PUNCT
eurjchem-885	64	1	2.2	2.2	NUM
eurjchem-885	64	2	.	.	PUNCT
eurjchem-885	64	3	reagents	reagent	NOUN
eurjchem-885	64	4	and	and	CCONJ
eurjchem-885	64	5	chemicals	chemical	NOUN
eurjchem-885	64	6	all	all	DET
eurjchem-885	64	7	reagents	reagent	NOUN
eurjchem-885	64	8	were	be	AUX
eurjchem-885	64	9	of	of	ADP
eurjchem-885	64	10	analytical	analytical	ADJ
eurjchem-885	64	11	reagent	reagent	ADJ
eurjchem-885	64	12	grade	grade	NOUN
eurjchem-885	64	13	and	and	CCONJ
eurjchem-885	64	14	solvents	solvent	NOUN
eurjchem-885	64	15	were	be	AUX
eurjchem-885	64	16	of	of	ADP
eurjchem-885	64	17	hplc	hplc	NOUN
eurjchem-885	64	18	grade	grade	NOUN
eurjchem-885	64	19	.	.	PUNCT
eurjchem-885	65	1	high	high	ADJ
eurjchem-885	65	2	purity	purity	NOUN
eurjchem-885	65	3	water	water	NOUN
eurjchem-885	65	4	was	be	AUX
eurjchem-885	65	5	obtained	obtain	VERB
eurjchem-885	65	6	by	by	ADP
eurjchem-885	65	7	elga	elga	ADJ
eurjchem-885	65	8	labwater	labwater	NOUN
eurjchem-885	65	9	,	,	PUNCT
eurjchem-885	65	10	prima	prima	NOUN
eurjchem-885	65	11	7	7	NUM
eurjchem-885	65	12	(	(	PUNCT
eurjchem-885	65	13	uk	uk	PROPN
eurjchem-885	65	14	)	)	PUNCT
eurjchem-885	65	15	and	and	CCONJ
eurjchem-885	65	16	it	it	PRON
eurjchem-885	65	17	was	be	AUX
eurjchem-885	65	18	used	use	VERB
eurjchem-885	65	19	throughout	throughout	ADP
eurjchem-885	65	20	the	the	DET
eurjchem-885	65	21	study	study	NOUN
eurjchem-885	65	22	.	.	PUNCT
eurjchem-885	66	1	methanol	methanol	NOUN
eurjchem-885	66	2	,	,	PUNCT
eurjchem-885	66	3	1‐propanol	1‐propanol	NUM
eurjchem-885	66	4	and	and	CCONJ
eurjchem-885	66	5	acetonitrile	acetonitrile	ADJ
eurjchem-885	66	6	(	(	PUNCT
eurjchem-885	66	7	hplc	hplc	NOUN
eurjchem-885	66	8	grade	grade	NOUN
eurjchem-885	66	9	)	)	PUNCT
eurjchem-885	66	10	were	be	AUX
eurjchem-885	66	11	obtained	obtain	VERB
eurjchem-885	66	12	from	from	ADP
eurjchem-885	66	13	sigma‐aldrich	sigma‐aldrich	NOUN
eurjchem-885	66	14	(	(	PUNCT
eurjchem-885	66	15	germany	germany	PROPN
eurjchem-885	66	16	)	)	PUNCT
eurjchem-885	66	17	.	.	PUNCT
eurjchem-885	67	1	ortho‐phosphoric	ortho‐phosphoric	ADJ
eurjchem-885	67	2	acid	acid	PROPN
eurjchem-885	67	3	(	(	PUNCT
eurjchem-885	67	4	85	85	NUM
eurjchem-885	67	5	%	%	NOUN
eurjchem-885	67	6	,	,	PUNCT
eurjchem-885	67	7	w	w	NOUN
eurjchem-885	67	8	:	:	SYM
eurjchem-885	67	9	v	v	NOUN
eurjchem-885	67	10	)	)	PUNCT
eurjchem-885	67	11	,	,	PUNCT
eurjchem-885	67	12	triethylamine	triethylamine	NOUN
eurjchem-885	67	13	(	(	PUNCT
eurjchem-885	67	14	tea	tea	NOUN
eurjchem-885	67	15	)	)	PUNCT
eurjchem-885	67	16	and	and	CCONJ
eurjchem-885	67	17	sodium	sodium	NOUN
eurjchem-885	67	18	dodecyl	dodecyl	PROPN
eurjchem-885	67	19	sulphate	sulphate	NOUN
eurjchem-885	67	20	(	(	PUNCT
eurjchem-885	67	21	sds	sds	PROPN
eurjchem-885	67	22	,	,	PUNCT
eurjchem-885	67	23	99	99	NUM
eurjchem-885	67	24	%	%	NOUN
eurjchem-885	67	25	)	)	PUNCT
eurjchem-885	67	26	were	be	AUX
eurjchem-885	67	27	obtained	obtain	VERB
eurjchem-885	67	28	from	from	ADP
eurjchem-885	67	29	riedel‐dehäen	riedel‐dehäen	PROPN
eurjchem-885	67	30	(	(	PUNCT
eurjchem-885	67	31	sleeze	sleeze	PROPN
eurjchem-885	67	32	,	,	PUNCT
eurjchem-885	67	33	germany	germany	PROPN
eurjchem-885	67	34	)	)	PUNCT
eurjchem-885	67	35	.	.	PUNCT
eurjchem-885	68	1	sodium	sodium	NOUN
eurjchem-885	68	2	hydroxide	hydroxide	PROPN
eurjchem-885	68	3	,	,	PUNCT
eurjchem-885	68	4	hydrochloric	hydrochloric	ADJ
eurjchem-885	68	5	acid	acid	NOUN
eurjchem-885	68	6	(	(	PUNCT
eurjchem-885	68	7	32	32	NUM
eurjchem-885	68	8	%	%	NOUN
eurjchem-885	68	9	,	,	PUNCT
eurjchem-885	68	10	w	w	NOUN
eurjchem-885	68	11	:	:	SYM
eurjchem-885	68	12	v	v	NOUN
eurjchem-885	68	13	)	)	PUNCT
eurjchem-885	68	14	were	be	AUX
eurjchem-885	68	15	purchased	purchase	VERB
eurjchem-885	68	16	from	from	ADP
eurjchem-885	68	17	el‐nasr	el‐nasr	PROPN
eurjchem-885	68	18	company	company	NOUN
eurjchem-885	68	19	,	,	PUNCT
eurjchem-885	68	20	egypt	egypt	PROPN
eurjchem-885	68	21	.	.	PUNCT
eurjchem-885	69	1	hydrogen	hydrogen	NOUN
eurjchem-885	69	2	peroxide	peroxide	NOUN
eurjchem-885	69	3	(	(	PUNCT
eurjchem-885	69	4	30	30	NUM
eurjchem-885	69	5	%	%	NOUN
eurjchem-885	69	6	,	,	PUNCT
eurjchem-885	69	7	w	w	NOUN
eurjchem-885	69	8	:	:	SYM
eurjchem-885	69	9	v	v	NOUN
eurjchem-885	69	10	)	)	PUNCT
eurjchem-885	69	11	was	be	AUX
eurjchem-885	69	12	obtained	obtain	VERB
eurjchem-885	69	13	from	from	ADP
eurjchem-885	69	14	luna	luna	PROPN
eurjchem-885	69	15	industrial	industrial	PROPN
eurjchem-885	69	16	group	group	NOUN
eurjchem-885	69	17	(	(	PUNCT
eurjchem-885	69	18	6th	6th	NOUN
eurjchem-885	69	19	of	of	ADP
eurjchem-885	69	20	october	october	PROPN
eurjchem-885	69	21	city	city	PROPN
eurjchem-885	69	22	,	,	PUNCT
eurjchem-885	69	23	egypt	egypt	PROPN
eurjchem-885	69	24	)	)	PUNCT
eurjchem-885	69	25	.	.	PUNCT
eurjchem-885	70	1	2.3	2.3	NUM
eurjchem-885	70	2	.	.	PUNCT
eurjchem-885	71	1	instrumentations	instrumentation	NOUN
eurjchem-885	71	2	the	the	DET
eurjchem-885	71	3	mlc	mlc	PROPN
eurjchem-885	71	4	method	method	NOUN
eurjchem-885	71	5	was	be	AUX
eurjchem-885	71	6	performed	perform	VERB
eurjchem-885	71	7	on	on	ADP
eurjchem-885	71	8	a	a	DET
eurjchem-885	71	9	gilson	gilson	NOUN
eurjchem-885	71	10	hplc	hplc	NOUN
eurjchem-885	71	11	system	system	NOUN
eurjchem-885	71	12	equipped	equip	VERB
eurjchem-885	71	13	with	with	ADP
eurjchem-885	71	14	a	a	DET
eurjchem-885	71	15	uv‐vis	uv‐vis	ADJ
eurjchem-885	71	16	156	156	NUM
eurjchem-885	71	17	detector	detector	NOUN
eurjchem-885	71	18	and	and	CCONJ
eurjchem-885	71	19	gilson	gilson	PROPN
eurjchem-885	71	20	321	321	NUM
eurjchem-885	71	21	pump	pump	NOUN
eurjchem-885	71	22	.	.	PUNCT
eurjchem-885	72	1	(	(	PUNCT
eurjchem-885	72	2	middleton	middleton	PROPN
eurjchem-885	72	3	,	,	PUNCT
eurjchem-885	72	4	usa	usa	PROPN
eurjchem-885	72	5	)	)	PUNCT
eurjchem-885	72	6	.	.	PUNCT
eurjchem-885	73	1	analytical	analytical	ADJ
eurjchem-885	73	2	data	datum	NOUN
eurjchem-885	73	3	is	be	AUX
eurjchem-885	73	4	stored	store	VERB
eurjchem-885	73	5	in	in	ADP
eurjchem-885	73	6	a	a	DET
eurjchem-885	73	7	computer	computer	NOUN
eurjchem-885	73	8	equipped	equip	VERB
eurjchem-885	73	9	with	with	ADP
eurjchem-885	73	10	unipoint	unipoint	NOUN
eurjchem-885	73	11	software	software	NOUN
eurjchem-885	73	12	and	and	CCONJ
eurjchem-885	73	13	connected	connect	VERB
eurjchem-885	73	14	to	to	ADP
eurjchem-885	73	15	the	the	DET
eurjchem-885	73	16	chromatographic	chromatographic	ADJ
eurjchem-885	73	17	system	system	NOUN
eurjchem-885	73	18	by	by	ADP
eurjchem-885	73	19	a	a	DET
eurjchem-885	73	20	gilson	gilson	NOUN
eurjchem-885	73	21	system	system	NOUN
eurjchem-885	73	22	interface	interface	NOUN
eurjchem-885	73	23	.	.	PUNCT
eurjchem-885	74	1	vortex	vortex	NOUN
eurjchem-885	74	2	used	use	VERB
eurjchem-885	74	3	was	be	AUX
eurjchem-885	74	4	vwr	vwr	PROPN
eurjchem-885	74	5	vv3	vv3	ADP
eurjchem-885	74	6	s540	s540	PROPN
eurjchem-885	74	7	international	international	ADJ
eurjchem-885	74	8	west	west	PROPN
eurjchem-885	74	9	charter‐usa	charter‐usa	PROPN
eurjchem-885	74	10	.	.	PUNCT
eurjchem-885	75	1	centrifuge	centrifuge	PROPN
eurjchem-885	75	2	used	use	VERB
eurjchem-885	75	3	was	be	AUX
eurjchem-885	75	4	centurion	centurion	NOUN
eurjchem-885	75	5	,	,	PUNCT
eurjchem-885	75	6	(	(	PUNCT
eurjchem-885	75	7	west	west	NOUN
eurjchem-885	75	8	sussex‐uk	sussex‐uk	PROPN
eurjchem-885	75	9	)	)	PUNCT
eurjchem-885	75	10	.	.	PUNCT
eurjchem-885	76	1	the	the	DET
eurjchem-885	76	2	ph	ph	PROPN
eurjchem-885	76	3	was	be	AUX
eurjchem-885	76	4	measured	measure	VERB
eurjchem-885	76	5	with	with	ADP
eurjchem-885	76	6	jenway	jenway	NOUN
eurjchem-885	76	7	ph	ph	ADJ
eurjchem-885	76	8	meter	meter	NOUN
eurjchem-885	76	9	,	,	PUNCT
eurjchem-885	76	10	3510	3510	NUM
eurjchem-885	76	11	,	,	PUNCT
eurjchem-885	76	12	(	(	PUNCT
eurjchem-885	76	13	essex‐uk	essex‐uk	PROPN
eurjchem-885	76	14	)	)	PUNCT
eurjchem-885	76	15	.	.	PUNCT
eurjchem-885	77	1	the	the	DET
eurjchem-885	77	2	mobile	mobile	ADJ
eurjchem-885	77	3	phase	phase	NOUN
eurjchem-885	77	4	was	be	AUX
eurjchem-885	77	5	filtered	filter	VERB
eurjchem-885	77	6	through	through	ADP
eurjchem-885	77	7	charles	charles	PROPN
eurjchem-885	77	8	austen	austen	PROPN
eurjchem-885	77	9	pumps	pumps	PROPN
eurjchem-885	77	10	ltd	ltd	PROPN
eurjchem-885	77	11	.	.	PROPN
eurjchem-885	77	12	filter	filter	PROPN
eurjchem-885	77	13	,	,	PUNCT
eurjchem-885	77	14	model‐b100	model‐b100	X
eurjchem-885	77	15	se	se	X
eurjchem-885	77	16	(	(	PUNCT
eurjchem-885	77	17	england	england	PROPN
eurjchem-885	77	18	,	,	PUNCT
eurjchem-885	77	19	uk	uk	PROPN
eurjchem-885	77	20	)	)	PUNCT
eurjchem-885	77	21	using	use	VERB
eurjchem-885	77	22	0.45	0.45	NUM
eurjchem-885	77	23	μm	μm	NOUN
eurjchem-885	77	24	milli‐pore	milli‐pore	NOUN
eurjchem-885	77	25	filters	filter	NOUN
eurjchem-885	77	26	(	(	PUNCT
eurjchem-885	77	27	gelman	gelman	PROPN
eurjchem-885	77	28	,	,	PUNCT
eurjchem-885	77	29	germany	germany	PROPN
eurjchem-885	77	30	)	)	PUNCT
eurjchem-885	77	31	.	.	PUNCT
eurjchem-885	78	1	uv‐visible	uv‐visible	ADJ
eurjchem-885	78	2	spectrophotometer	spectrophotometer	NOUN
eurjchem-885	78	3	used	use	VERB
eurjchem-885	78	4	was	be	AUX
eurjchem-885	78	5	jasco	jasco	PROPN
eurjchem-885	78	6	,	,	PUNCT
eurjchem-885	78	7	v‐530	v‐530	PROPN
eurjchem-885	78	8	,	,	PUNCT
eurjchem-885	78	9	(	(	PUNCT
eurjchem-885	78	10	tokyo	tokyo	PROPN
eurjchem-885	78	11	,	,	PUNCT
eurjchem-885	78	12	japan	japan	PROPN
eurjchem-885	78	13	)	)	PUNCT
eurjchem-885	78	14	.	.	PUNCT
eurjchem-885	79	1	ultrasonic	ultrasonic	ADJ
eurjchem-885	79	2	bath	bath	NOUN
eurjchem-885	79	3	used	use	VERB
eurjchem-885	79	4	was	be	AUX
eurjchem-885	79	5	falc	falc	NOUN
eurjchem-885	79	6	,	,	PUNCT
eurjchem-885	79	7	(	(	PUNCT
eurjchem-885	79	8	treviglio‐italy	treviglio‐italy	PROPN
eurjchem-885	79	9	)	)	PUNCT
eurjchem-885	79	10	.	.	PUNCT
eurjchem-885	80	1	2.4	2.4	NUM
eurjchem-885	80	2	.	.	PUNCT
eurjchem-885	80	3	chromatographic	chromatographic	ADJ
eurjchem-885	80	4	conditions	condition	NOUN
eurjchem-885	80	5	mlc	mlc	NOUN
eurjchem-885	80	6	was	be	AUX
eurjchem-885	80	7	performed	perform	VERB
eurjchem-885	80	8	on	on	ADP
eurjchem-885	80	9	a	a	DET
eurjchem-885	80	10	µbondapack	µbondapack	NOUN
eurjchem-885	80	11	cyano	cyano	NOUN
eurjchem-885	80	12	column	column	NOUN
eurjchem-885	80	13	(	(	PUNCT
eurjchem-885	80	14	3.9	3.9	NUM
eurjchem-885	80	15	×	×	NOUN
eurjchem-885	80	16	150	150	NUM
eurjchem-885	80	17	mm	mm	NOUN
eurjchem-885	80	18	,	,	PUNCT
eurjchem-885	80	19	5	5	NUM
eurjchem-885	80	20	µm	µm	ADP
eurjchem-885	80	21	particle	particle	NOUN
eurjchem-885	80	22	size	size	NOUN
eurjchem-885	80	23	)	)	PUNCT
eurjchem-885	80	24	,	,	PUNCT
eurjchem-885	80	25	waters	water	VERB
eurjchem-885	80	26	corporation	corporation	NOUN
eurjchem-885	80	27	,	,	PUNCT
eurjchem-885	80	28	ireland	ireland	NOUN
eurjchem-885	80	29	using	use	VERB
eurjchem-885	80	30	micellar	micellar	ADJ
eurjchem-885	80	31	mobile	mobile	ADJ
eurjchem-885	80	32	phase	phase	NOUN
eurjchem-885	80	33	consisting	consist	VERB
eurjchem-885	80	34	of	of	ADP
eurjchem-885	80	35	0.1	0.1	NUM
eurjchem-885	80	36	m	m	NOUN
eurjchem-885	80	37	sodium	sodium	NOUN
eurjchem-885	80	38	dodecyl	dodecyl	NOUN
eurjchem-885	80	39	sulphate	sulphate	NOUN
eurjchem-885	80	40	(	(	PUNCT
eurjchem-885	80	41	sds	sds	PROPN
eurjchem-885	80	42	)	)	PUNCT
eurjchem-885	80	43	,	,	PUNCT
eurjchem-885	80	44	20	20	NUM
eurjchem-885	80	45	%	%	NOUN
eurjchem-885	80	46	1‐propanol	1‐propanol	NOUN
eurjchem-885	80	47	,	,	PUNCT
eurjchem-885	81	1	0.3	0.3	NUM
eurjchem-885	81	2	%	%	NOUN
eurjchem-885	81	3	triethylamine	triethylamine	NOUN
eurjchem-885	81	4	(	(	PUNCT
eurjchem-885	81	5	tea	tea	NOUN
eurjchem-885	81	6	)	)	PUNCT
eurjchem-885	81	7	in	in	ADP
eurjchem-885	81	8	0.02	0.02	NUM
eurjchem-885	81	9	m	m	NOUN
eurjchem-885	81	10	ortho‐phosphoric	ortho‐phosphoric	ADJ
eurjchem-885	81	11	acid	acid	NOUN
eurjchem-885	81	12	(	(	PUNCT
eurjchem-885	81	13	ph	ph	NOUN
eurjchem-885	81	14	=	=	NOUN
eurjchem-885	81	15	3.5	3.5	NUM
eurjchem-885	81	16	)	)	PUNCT
eurjchem-885	81	17	.	.	PUNCT
eurjchem-885	82	1	the	the	DET
eurjchem-885	82	2	mobile	mobile	ADJ
eurjchem-885	82	3	phase	phase	NOUN
eurjchem-885	82	4	was	be	AUX
eurjchem-885	82	5	filtered	filter	VERB
eurjchem-885	82	6	and	and	CCONJ
eurjchem-885	82	7	sonicated	sonicate	VERB
eurjchem-885	82	8	for	for	ADP
eurjchem-885	82	9	30	30	NUM
eurjchem-885	82	10	min	min	NOUN
eurjchem-885	82	11	before	before	ADP
eurjchem-885	82	12	use	use	NOUN
eurjchem-885	82	13	.	.	PUNCT
eurjchem-885	83	1	the	the	DET
eurjchem-885	83	2	flow	flow	NOUN
eurjchem-885	83	3	rate	rate	NOUN
eurjchem-885	83	4	was	be	AUX
eurjchem-885	83	5	2.0	2.0	NUM
eurjchem-885	83	6	ml	ml	NOUN
eurjchem-885	83	7	/	/	SYM
eurjchem-885	83	8	min	min	NOUN
eurjchem-885	83	9	and	and	CCONJ
eurjchem-885	83	10	sample	sample	NOUN
eurjchem-885	83	11	injection	injection	NOUN
eurjchem-885	83	12	volumes	volume	NOUN
eurjchem-885	83	13	were	be	AUX
eurjchem-885	83	14	20	20	NUM
eurjchem-885	83	15	µl	µl	NOUN
eurjchem-885	83	16	at	at	ADP
eurjchem-885	83	17	room	room	NOUN
eurjchem-885	83	18	temperature	temperature	NOUN
eurjchem-885	83	19	(	(	PUNCT
eurjchem-885	83	20	25	25	NUM
eurjchem-885	83	21	°	°	NOUN
eurjchem-885	83	22	c	c	NOUN
eurjchem-885	83	23	)	)	PUNCT
eurjchem-885	83	24	.	.	PUNCT
eurjchem-885	84	1	the	the	DET
eurjchem-885	84	2	uv	uv	NOUN
eurjchem-885	84	3	detector	detector	NOUN
eurjchem-885	84	4	was	be	AUX
eurjchem-885	84	5	operated	operate	VERB
eurjchem-885	84	6	at	at	ADP
eurjchem-885	84	7	258	258	NUM
eurjchem-885	84	8	nm	nm	NOUN
eurjchem-885	84	9	.	.	PUNCT
eurjchem-885	85	1	2.5	2.5	NUM
eurjchem-885	85	2	.	.	PUNCT
eurjchem-885	86	1	standard	standard	ADJ
eurjchem-885	86	2	solutions	solution	NOUN
eurjchem-885	86	3	standard	standard	ADJ
eurjchem-885	86	4	stock	stock	NOUN
eurjchem-885	86	5	solution	solution	NOUN
eurjchem-885	86	6	(	(	PUNCT
eurjchem-885	86	7	400	400	NUM
eurjchem-885	86	8	µg	µg	NOUN
eurjchem-885	86	9	/	/	SYM
eurjchem-885	86	10	ml	ml	NOUN
eurjchem-885	86	11	)	)	PUNCT
eurjchem-885	86	12	of	of	ADP
eurjchem-885	86	13	itc	itc	PROPN
eurjchem-885	86	14	was	be	AUX
eurjchem-885	86	15	prepared	prepare	VERB
eurjchem-885	86	16	by	by	ADP
eurjchem-885	86	17	dissolving	dissolve	VERB
eurjchem-885	86	18	10	10	NUM
eurjchem-885	86	19	mg	mg	PROPN
eurjchem-885	86	20	itc	itc	PROPN
eurjchem-885	86	21	in	in	ADP
eurjchem-885	86	22	25	25	NUM
eurjchem-885	86	23	ml	ml	NOUN
eurjchem-885	86	24	methanol	methanol	NOUN
eurjchem-885	86	25	then	then	ADV
eurjchem-885	86	26	the	the	DET
eurjchem-885	86	27	solution	solution	NOUN
eurjchem-885	86	28	was	be	AUX
eurjchem-885	86	29	sonicated	sonicate	VERB
eurjchem-885	86	30	in	in	ADP
eurjchem-885	86	31	an	an	DET
eurjchem-885	86	32	ultrasonic	ultrasonic	ADJ
eurjchem-885	86	33	bath	bath	NOUN
eurjchem-885	86	34	for	for	ADP
eurjchem-885	86	35	5	5	NUM
eurjchem-885	86	36	minutes	minute	NOUN
eurjchem-885	86	37	.	.	PUNCT
eurjchem-885	87	1	the	the	DET
eurjchem-885	87	2	solutions	solution	NOUN
eurjchem-885	87	3	were	be	AUX
eurjchem-885	87	4	found	find	VERB
eurjchem-885	87	5	to	to	PART
eurjchem-885	87	6	be	be	AUX
eurjchem-885	87	7	stable	stable	ADJ
eurjchem-885	87	8	for	for	ADP
eurjchem-885	87	9	3	3	NUM
eurjchem-885	87	10	days	day	NOUN
eurjchem-885	87	11	at	at	ADP
eurjchem-885	87	12	room	room	NOUN
eurjchem-885	87	13	temperature	temperature	NOUN
eurjchem-885	87	14	.	.	PUNCT
eurjchem-885	88	1	working	work	VERB
eurjchem-885	88	2	standard	standard	ADJ
eurjchem-885	88	3	solutions	solution	NOUN
eurjchem-885	88	4	(	(	PUNCT
eurjchem-885	88	5	120‐320	120‐320	NOUN
eurjchem-885	88	6	µg	µg	NOUN
eurjchem-885	88	7	/	/	SYM
eurjchem-885	88	8	ml	ml	NOUN
eurjchem-885	88	9	)	)	PUNCT
eurjchem-885	88	10	were	be	AUX
eurjchem-885	88	11	prepared	prepare	VERB
eurjchem-885	88	12	by	by	ADP
eurjchem-885	88	13	appropriate	appropriate	ADJ
eurjchem-885	88	14	dilutions	dilution	NOUN
eurjchem-885	88	15	of	of	ADP
eurjchem-885	88	16	the	the	DET
eurjchem-885	88	17	standard	standard	ADJ
eurjchem-885	88	18	stock	stock	NOUN
eurjchem-885	88	19	solution	solution	NOUN
eurjchem-885	88	20	with	with	ADP
eurjchem-885	88	21	the	the	DET
eurjchem-885	88	22	mobile	mobile	ADJ
eurjchem-885	88	23	phase	phase	NOUN
eurjchem-885	88	24	.	.	PUNCT
eurjchem-885	89	1	2.6	2.6	NUM
eurjchem-885	89	2	.	.	PUNCT
eurjchem-885	89	3	preparation	preparation	NOUN
eurjchem-885	89	4	of	of	ADP
eurjchem-885	89	5	pharmaceutical	pharmaceutical	NOUN
eurjchem-885	89	6	products	product	NOUN
eurjchem-885	89	7	take	take	VERB
eurjchem-885	89	8	the	the	DET
eurjchem-885	89	9	contents	content	NOUN
eurjchem-885	89	10	of	of	ADP
eurjchem-885	89	11	20	20	NUM
eurjchem-885	89	12	capsules	capsule	NOUN
eurjchem-885	89	13	and	and	CCONJ
eurjchem-885	89	14	determine	determine	VERB
eurjchem-885	89	15	the	the	DET
eurjchem-885	89	16	average	average	ADJ
eurjchem-885	89	17	weight	weight	NOUN
eurjchem-885	89	18	of	of	ADP
eurjchem-885	89	19	content	content	NOUN
eurjchem-885	89	20	per	per	ADP
eurjchem-885	89	21	capsule	capsule	NOUN
eurjchem-885	89	22	.	.	PUNCT
eurjchem-885	90	1	accurate	accurate	ADJ
eurjchem-885	90	2	weight	weight	NOUN
eurjchem-885	90	3	of	of	ADP
eurjchem-885	90	4	the	the	DET
eurjchem-885	90	5	powder	powder	NOUN
eurjchem-885	90	6	equivalent	equivalent	ADJ
eurjchem-885	90	7	to	to	ADP
eurjchem-885	90	8	10	10	NUM
eurjchem-885	90	9	mg	mg	PROPN
eurjchem-885	90	10	itc	itc	PROPN
eurjchem-885	90	11	was	be	AUX
eurjchem-885	90	12	dissolved	dissolve	VERB
eurjchem-885	90	13	in	in	ADP
eurjchem-885	90	14	25	25	NUM
eurjchem-885	90	15	ml	ml	NOUN
eurjchem-885	90	16	methanol	methanol	NOUN
eurjchem-885	90	17	then	then	ADV
eurjchem-885	90	18	sonication	sonication	NOUN
eurjchem-885	90	19	for	for	ADP
eurjchem-885	90	20	15	15	NUM
eurjchem-885	90	21	min	min	NOUN
eurjchem-885	90	22	and	and	CCONJ
eurjchem-885	90	23	filtered	filter	VERB
eurjchem-885	90	24	.	.	PUNCT
eurjchem-885	91	1	2.7	2.7	NUM
eurjchem-885	91	2	.	.	PUNCT
eurjchem-885	91	3	plasma	plasma	NOUN
eurjchem-885	91	4	sample	sample	NOUN
eurjchem-885	91	5	extraction	extraction	NOUN
eurjchem-885	91	6	1	1	NUM
eurjchem-885	91	7	ml	ml	NOUN
eurjchem-885	91	8	of	of	ADP
eurjchem-885	91	9	human	human	ADJ
eurjchem-885	91	10	plasma	plasma	NOUN
eurjchem-885	91	11	was	be	AUX
eurjchem-885	91	12	transferred	transfer	VERB
eurjchem-885	91	13	into	into	ADP
eurjchem-885	91	14	a	a	DET
eurjchem-885	91	15	centrifuge	centrifuge	NOUN
eurjchem-885	91	16	tube	tube	NOUN
eurjchem-885	91	17	,	,	PUNCT
eurjchem-885	91	18	spiked	spike	VERB
eurjchem-885	91	19	with	with	ADP
eurjchem-885	91	20	1	1	NUM
eurjchem-885	91	21	ml	ml	NOUN
eurjchem-885	91	22	of	of	ADP
eurjchem-885	91	23	itc	itc	PROPN
eurjchem-885	91	24	and	and	CCONJ
eurjchem-885	91	25	deprotenized	deprotenize	VERB
eurjchem-885	91	26	with	with	ADP
eurjchem-885	91	27	2	2	NUM
eurjchem-885	91	28	ml	ml	NOUN
eurjchem-885	91	29	acetonitrile	acetonitrile	NOUN
eurjchem-885	91	30	(	(	PUNCT
eurjchem-885	91	31	acn	acn	PROPN
eurjchem-885	91	32	)	)	PUNCT
eurjchem-885	91	33	,	,	PUNCT
eurjchem-885	91	34	then	then	ADV
eurjchem-885	91	35	vortex	vortex	NOUN
eurjchem-885	91	36	.	.	PUNCT
eurjchem-885	92	1	final	final	ADJ
eurjchem-885	92	2	concentrations	concentration	NOUN
eurjchem-885	92	3	were	be	AUX
eurjchem-885	92	4	125	125	NUM
eurjchem-885	92	5	,	,	PUNCT
eurjchem-885	92	6	150	150	NUM
eurjchem-885	92	7	and	and	CCONJ
eurjchem-885	92	8	175	175	NUM
eurjchem-885	92	9	µg	µg	INTJ
eurjchem-885	92	10	itc	itc	PROPN
eurjchem-885	92	11	/	/	SYM
eurjchem-885	92	12	ml	ml	PROPN
eurjchem-885	92	13	,	,	PUNCT
eurjchem-885	92	14	respectively	respectively	ADV
eurjchem-885	92	15	.	.	PUNCT
eurjchem-885	93	1	the	the	DET
eurjchem-885	93	2	solutions	solution	NOUN
eurjchem-885	93	3	were	be	AUX
eurjchem-885	93	4	centrifuged	centrifuge	VERB
eurjchem-885	93	5	at	at	ADP
eurjchem-885	93	6	5000	5000	NUM
eurjchem-885	93	7	rpm	rpm	NOUN
eurjchem-885	93	8	for	for	ADP
eurjchem-885	93	9	15	15	NUM
eurjchem-885	93	10	minutes	minute	NOUN
eurjchem-885	93	11	.	.	PUNCT
eurjchem-885	94	1	then	then	ADV
eurjchem-885	94	2	,	,	PUNCT
eurjchem-885	94	3	the	the	DET
eurjchem-885	94	4	solutions	solution	NOUN
eurjchem-885	94	5	were	be	AUX
eurjchem-885	94	6	filtered	filter	VERB
eurjchem-885	94	7	through	through	ADP
eurjchem-885	94	8	a	a	DET
eurjchem-885	94	9	disposable	disposable	ADJ
eurjchem-885	94	10	syringe	syringe	NOUN
eurjchem-885	94	11	filter	filter	NOUN
eurjchem-885	94	12	(	(	PUNCT
eurjchem-885	94	13	0.45	0.45	NUM
eurjchem-885	94	14	µm	µm	NOUN
eurjchem-885	94	15	)	)	PUNCT
eurjchem-885	94	16	before	before	ADP
eurjchem-885	94	17	column	column	NOUN
eurjchem-885	94	18	injection	injection	NOUN
eurjchem-885	94	19	.	.	PUNCT
eurjchem-885	95	1	rizk	rizk	PROPN
eurjchem-885	95	2	et	et	PROPN
eurjchem-885	95	3	al	al	PROPN
eurjchem-885	95	4	.	.	PUNCT
eurjchem-885	95	5	/	/	SYM
eurjchem-885	95	6	european	european	PROPN
eurjchem-885	95	7	journal	journal	PROPN
eurjchem-885	95	8	of	of	ADP
eurjchem-885	95	9	chemistry	chemistry	NOUN
eurjchem-885	95	10	5	5	NUM
eurjchem-885	95	11	(	(	PUNCT
eurjchem-885	95	12	1	1	NUM
eurjchem-885	95	13	)	)	PUNCT
eurjchem-885	95	14	(	(	PUNCT
eurjchem-885	95	15	2014	2014	NUM
eurjchem-885	95	16	)	)	PUNCT
eurjchem-885	95	17	11‐17	11‐17	NOUN
eurjchem-885	95	18	13	13	NUM
eurjchem-885	95	19	table	table	NOUN
eurjchem-885	95	20	1	1	NUM
eurjchem-885	95	21	.	.	PUNCT
eurjchem-885	95	22	optimization	optimization	NOUN
eurjchem-885	95	23	of	of	ADP
eurjchem-885	95	24	chromatographic	chromatographic	ADJ
eurjchem-885	95	25	conditions	condition	NOUN
eurjchem-885	95	26	for	for	ADP
eurjchem-885	95	27	the	the	DET
eurjchem-885	95	28	separation	separation	NOUN
eurjchem-885	95	29	of	of	ADP
eurjchem-885	95	30	itc	itc	PROPN
eurjchem-885	95	31	.	.	PUNCT
eurjchem-885	96	1	parameter	parameter	PROPN
eurjchem-885	96	2	variation	variation	NOUN
eurjchem-885	96	3	no	no	PRON
eurjchem-885	96	4	of	of	ADP
eurjchem-885	96	5	theoretical	theoretical	ADJ
eurjchem-885	96	6	plates	plate	NOUN
eurjchem-885	96	7	(	(	PUNCT
eurjchem-885	96	8	n	n	CCONJ
eurjchem-885	96	9	)	)	PUNCT
eurjchem-885	96	10	capacity	capacity	NOUN
eurjchem-885	96	11	factor	factor	NOUN
eurjchem-885	96	12	(	(	PUNCT
eurjchem-885	96	13	k	k	NOUN
eurjchem-885	96	14	’	'	PUNCT
eurjchem-885	96	15	)	)	PUNCT
eurjchem-885	96	16	selectivity	selectivity	NOUN
eurjchem-885	96	17	factor	factor	NOUN
eurjchem-885	96	18	(	(	PUNCT
eurjchem-885	96	19	α	α	NOUN
eurjchem-885	96	20	)	)	PUNCT
eurjchem-885	96	21	peak	peak	NOUN
eurjchem-885	96	22	width	width	NOUN
eurjchem-885	96	23	(	(	PUNCT
eurjchem-885	96	24	10	10	NUM
eurjchem-885	96	25	%	%	NOUN
eurjchem-885	96	26	)	)	PUNCT
eurjchem-885	96	27	tailing	tail	VERB
eurjchem-885	96	28	factor	factor	NOUN
eurjchem-885	96	29	(	(	PUNCT
eurjchem-885	96	30	tf	tf	NOUN
eurjchem-885	96	31	)	)	PUNCT
eurjchem-885	96	32	ph	ph	PROPN
eurjchem-885	96	33	2.5	2.5	NUM
eurjchem-885	96	34	640	640	NUM
eurjchem-885	96	35	2.15	2.15	NUM
eurjchem-885	96	36	6.26	6.26	NUM
eurjchem-885	96	37	0.59	0.59	NUM
eurjchem-885	96	38	1.46	1.46	NUM
eurjchem-885	96	39	3.5	3.5	NUM
eurjchem-885	96	40	505	505	NUM
eurjchem-885	96	41	1.43	1.43	NUM
eurjchem-885	96	42	4.77	4.77	NUM
eurjchem-885	96	43	0.38	0.38	NUM
eurjchem-885	96	44	1.23	1.23	NUM
eurjchem-885	96	45	4.5	4.5	NUM
eurjchem-885	96	46	465	465	NUM
eurjchem-885	96	47	1.39	1.39	NUM
eurjchem-885	96	48	4.73	4.73	NUM
eurjchem-885	96	49	0.36	0.36	NUM
eurjchem-885	96	50	1.25	1.25	NUM
eurjchem-885	96	51	conc	conc	NOUN
eurjchem-885	96	52	.	.	PUNCT
eurjchem-885	97	1	of	of	ADP
eurjchem-885	97	2	sds	sds	PROPN
eurjchem-885	97	3	(	(	PUNCT
eurjchem-885	97	4	m	m	PROPN
eurjchem-885	97	5	)	)	PUNCT
eurjchem-885	97	6	0.07	0.07	NUM
eurjchem-885	97	7	382	382	NUM
eurjchem-885	97	8	2.52	2.52	NUM
eurjchem-885	97	9	5.66	5.66	NUM
eurjchem-885	97	10	0.76	0.76	NUM
eurjchem-885	97	11	1.23	1.23	NUM
eurjchem-885	97	12	0.1	0.1	NUM
eurjchem-885	97	13	522	522	NUM
eurjchem-885	97	14	1.60	1.60	NUM
eurjchem-885	97	15	4.92	4.92	NUM
eurjchem-885	97	16	0.35	0.35	NUM
eurjchem-885	97	17	1.30	1.30	NUM
eurjchem-885	97	18	conc	conc	NOUN
eurjchem-885	97	19	.	.	PUNCT
eurjchem-885	98	1	of	of	ADP
eurjchem-885	98	2	1‐propanol	1‐propanol	NUM
eurjchem-885	98	3	(	(	PUNCT
eurjchem-885	98	4	%	%	NOUN
eurjchem-885	98	5	v	v	ADJ
eurjchem-885	98	6	:	:	PUNCT
eurjchem-885	98	7	v	v	NOUN
eurjchem-885	98	8	)	)	PUNCT
eurjchem-885	98	9	10	10	NUM
eurjchem-885	98	10	103	103	NUM
eurjchem-885	98	11	1.86	1.86	NUM
eurjchem-885	98	12	2.89	2.89	NUM
eurjchem-885	98	13	0.88	0.88	NUM
eurjchem-885	98	14	1.20	1.20	NUM
eurjchem-885	98	15	14	14	NUM
eurjchem-885	98	16	177	177	NUM
eurjchem-885	98	17	1.76	1.76	NUM
eurjchem-885	98	18	2.80	2.80	NUM
eurjchem-885	98	19	0.74	0.74	NUM
eurjchem-885	98	20	1.26	1.26	NUM
eurjchem-885	98	21	20	20	NUM
eurjchem-885	98	22	522	522	NUM
eurjchem-885	98	23	1.60	1.60	NUM
eurjchem-885	98	24	4.83	4.83	NUM
eurjchem-885	98	25	0.37	0.37	NUM
eurjchem-885	98	26	1.30	1.30	NUM
eurjchem-885	98	27	flow	flow	NOUN
eurjchem-885	98	28	rate	rate	NOUN
eurjchem-885	98	29	(	(	PUNCT
eurjchem-885	98	30	ml	ml	NOUN
eurjchem-885	98	31	/	/	SYM
eurjchem-885	98	32	min	min	NOUN
eurjchem-885	98	33	)	)	PUNCT
eurjchem-885	98	34	1.0	1.0	NUM
eurjchem-885	98	35	525	525	NUM
eurjchem-885	98	36	4.54	4.54	NUM
eurjchem-885	98	37	7.08	7.08	NUM
eurjchem-885	98	38	1.25	1.25	NUM
eurjchem-885	98	39	1.42	1.42	NUM
eurjchem-885	98	40	1.5	1.5	NUM
eurjchem-885	98	41	562	562	NUM
eurjchem-885	98	42	4.58	4.58	NUM
eurjchem-885	98	43	7.34	7.34	NUM
eurjchem-885	98	44	0.98	0.98	NUM
eurjchem-885	98	45	1.44	1.44	NUM
eurjchem-885	98	46	2.0	2.0	NUM
eurjchem-885	98	47	575	575	NUM
eurjchem-885	98	48	1.60	1.60	NUM
eurjchem-885	98	49	3.60	3.60	NUM
eurjchem-885	98	50	0.36	0.36	NUM
eurjchem-885	98	51	1.23	1.23	NUM
eurjchem-885	98	52	conc	conc	NOUN
eurjchem-885	98	53	.	.	PUNCT
eurjchem-885	99	1	of	of	ADP
eurjchem-885	99	2	tea	tea	NOUN
eurjchem-885	100	1	(	(	PUNCT
eurjchem-885	100	2	%	%	NOUN
eurjchem-885	100	3	v	v	ADJ
eurjchem-885	100	4	:	:	PUNCT
eurjchem-885	100	5	v	v	NOUN
eurjchem-885	100	6	)	)	PUNCT
eurjchem-885	100	7	0.2	0.2	NUM
eurjchem-885	100	8	96	96	NUM
eurjchem-885	100	9	1.69	1.69	NUM
eurjchem-885	100	10	2.75	2.75	NUM
eurjchem-885	100	11	0.70	0.70	NUM
eurjchem-885	100	12	1.30	1.30	NUM
eurjchem-885	100	13	0.3	0.3	NUM
eurjchem-885	100	14	505	505	NUM
eurjchem-885	100	15	1.60	1.60	NUM
eurjchem-885	100	16	3.60	3.60	NUM
eurjchem-885	100	17	0.36	0.36	NUM
eurjchem-885	100	18	1.20	1.20	NUM
eurjchem-885	100	19	2.8	2.8	NUM
eurjchem-885	100	20	.	.	PUNCT
eurjchem-885	101	1	sample	sample	NOUN
eurjchem-885	101	2	degradation	degradation	NOUN
eurjchem-885	101	3	an	an	DET
eurjchem-885	101	4	appropriate	appropriate	ADJ
eurjchem-885	101	5	amount	amount	NOUN
eurjchem-885	101	6	of	of	ADP
eurjchem-885	101	7	itc	itc	NOUN
eurjchem-885	101	8	at	at	ADP
eurjchem-885	101	9	a	a	DET
eurjchem-885	101	10	final	final	ADJ
eurjchem-885	101	11	concentration	concentration	NOUN
eurjchem-885	101	12	of	of	ADP
eurjchem-885	101	13	500	500	NUM
eurjchem-885	101	14	µg	µg	NOUN
eurjchem-885	101	15	/	/	SYM
eurjchem-885	101	16	ml	ml	NOUN
eurjchem-885	101	17	in	in	ADP
eurjchem-885	101	18	1	1	NUM
eurjchem-885	101	19	n	n	DET
eurjchem-885	101	20	alcoholic	alcoholic	ADJ
eurjchem-885	101	21	hcl	hcl	PROPN
eurjchem-885	101	22	was	be	AUX
eurjchem-885	101	23	left	leave	VERB
eurjchem-885	101	24	for	for	ADP
eurjchem-885	101	25	24	24	NUM
eurjchem-885	101	26	hours	hour	NOUN
eurjchem-885	101	27	then	then	ADV
eurjchem-885	101	28	the	the	DET
eurjchem-885	101	29	solution	solution	NOUN
eurjchem-885	101	30	was	be	AUX
eurjchem-885	101	31	filtered	filter	VERB
eurjchem-885	101	32	and	and	CCONJ
eurjchem-885	101	33	4	4	NUM
eurjchem-885	101	34	ml	ml	NOUN
eurjchem-885	101	35	was	be	AUX
eurjchem-885	101	36	taken	take	VERB
eurjchem-885	101	37	into	into	ADP
eurjchem-885	101	38	10	10	NUM
eurjchem-885	101	39	ml	ml	NOUN
eurjchem-885	101	40	volumetric	volumetric	ADJ
eurjchem-885	101	41	flask	flask	NOUN
eurjchem-885	101	42	and	and	CCONJ
eurjchem-885	101	43	the	the	DET
eurjchem-885	101	44	volume	volume	NOUN
eurjchem-885	101	45	was	be	AUX
eurjchem-885	101	46	completed	complete	VERB
eurjchem-885	101	47	with	with	ADP
eurjchem-885	101	48	the	the	DET
eurjchem-885	101	49	mobile	mobile	ADJ
eurjchem-885	101	50	phase	phase	NOUN
eurjchem-885	101	51	,	,	PUNCT
eurjchem-885	101	52	sonicated	sonicate	VERB
eurjchem-885	101	53	and	and	CCONJ
eurjchem-885	101	54	triplicate	triplicate	VERB
eurjchem-885	101	55	20	20	NUM
eurjchem-885	101	56	µl	µl	ADP
eurjchem-885	101	57	injections	injection	NOUN
eurjchem-885	101	58	were	be	AUX
eurjchem-885	101	59	made	make	VERB
eurjchem-885	101	60	.	.	PUNCT
eurjchem-885	102	1	the	the	DET
eurjchem-885	102	2	same	same	ADJ
eurjchem-885	102	3	experiment	experiment	NOUN
eurjchem-885	102	4	was	be	AUX
eurjchem-885	102	5	repeated	repeat	VERB
eurjchem-885	102	6	but	but	CCONJ
eurjchem-885	102	7	in	in	ADP
eurjchem-885	102	8	1	1	NUM
eurjchem-885	102	9	n	n	PRON
eurjchem-885	102	10	alcoholic	alcoholic	ADJ
eurjchem-885	102	11	naoh	naoh	NOUN
eurjchem-885	102	12	,	,	PUNCT
eurjchem-885	102	13	30	30	NUM
eurjchem-885	102	14	%	%	NOUN
eurjchem-885	102	15	h2o2	h2o2	NOUN
eurjchem-885	102	16	or	or	CCONJ
eurjchem-885	102	17	the	the	DET
eurjchem-885	102	18	solutions	solution	NOUN
eurjchem-885	102	19	of	of	ADP
eurjchem-885	102	20	itc	itc	PROPN
eurjchem-885	102	21	were	be	AUX
eurjchem-885	102	22	left	leave	VERB
eurjchem-885	102	23	in	in	ADP
eurjchem-885	102	24	the	the	DET
eurjchem-885	102	25	sunlight	sunlight	NOUN
eurjchem-885	102	26	for	for	ADP
eurjchem-885	102	27	24	24	NUM
eurjchem-885	102	28	hrs	hrs	NOUN
eurjchem-885	102	29	.	.	PUNCT
eurjchem-885	103	1	each	each	DET
eurjchem-885	103	2	experiment	experiment	NOUN
eurjchem-885	103	3	was	be	AUX
eurjchem-885	103	4	carried	carry	VERB
eurjchem-885	103	5	out	out	ADP
eurjchem-885	103	6	in	in	ADP
eurjchem-885	103	7	triplicate	triplicate	NOUN
eurjchem-885	103	8	and	and	CCONJ
eurjchem-885	103	9	all	all	DET
eurjchem-885	103	10	solutions	solution	NOUN
eurjchem-885	103	11	were	be	AUX
eurjchem-885	103	12	injected	inject	VERB
eurjchem-885	103	13	in	in	ADP
eurjchem-885	103	14	triplicate	triplicate	NOUN
eurjchem-885	103	15	.	.	PUNCT
eurjchem-885	104	1	the	the	DET
eurjchem-885	104	2	nominal	nominal	ADJ
eurjchem-885	104	3	contents	content	NOUN
eurjchem-885	104	4	of	of	ADP
eurjchem-885	104	5	itc	itc	PROPN
eurjchem-885	104	6	were	be	AUX
eurjchem-885	104	7	calculated	calculate	VERB
eurjchem-885	104	8	using	use	VERB
eurjchem-885	104	9	the	the	DET
eurjchem-885	104	10	constructed	construct	VERB
eurjchem-885	104	11	calibration	calibration	NOUN
eurjchem-885	104	12	graph	graph	NOUN
eurjchem-885	104	13	or	or	CCONJ
eurjchem-885	104	14	from	from	ADP
eurjchem-885	104	15	the	the	DET
eurjchem-885	104	16	corresponding	corresponding	ADJ
eurjchem-885	104	17	regression	regression	NOUN
eurjchem-885	104	18	equation	equation	NOUN
eurjchem-885	104	19	3	3	NUM
eurjchem-885	104	20	.	.	NOUN
eurjchem-885	104	21	results	result	NOUN
eurjchem-885	104	22	and	and	CCONJ
eurjchem-885	104	23	discussion	discussion	NOUN
eurjchem-885	104	24	the	the	DET
eurjchem-885	104	25	proposed	propose	VERB
eurjchem-885	104	26	mlc	mlc	NOUN
eurjchem-885	104	27	method	method	NOUN
eurjchem-885	104	28	represents	represent	VERB
eurjchem-885	104	29	a	a	DET
eurjchem-885	104	30	rapid	rapid	ADJ
eurjchem-885	104	31	and	and	CCONJ
eurjchem-885	104	32	sensitive	sensitive	ADJ
eurjchem-885	104	33	stability‐indicating	stability‐indicate	VERB
eurjchem-885	104	34	assay	assay	NOUN
eurjchem-885	104	35	method	method	NOUN
eurjchem-885	104	36	for	for	ADP
eurjchem-885	104	37	the	the	DET
eurjchem-885	104	38	simultaneous	simultaneous	ADJ
eurjchem-885	104	39	determination	determination	NOUN
eurjchem-885	104	40	of	of	ADP
eurjchem-885	104	41	itc	itc	PROPN
eurjchem-885	104	42	in	in	ADP
eurjchem-885	104	43	bulk	bulk	ADJ
eurjchem-885	104	44	and	and	CCONJ
eurjchem-885	104	45	commercial	commercial	ADJ
eurjchem-885	104	46	capsules	capsule	NOUN
eurjchem-885	104	47	.	.	PUNCT
eurjchem-885	105	1	by	by	ADP
eurjchem-885	105	2	virtue	virtue	NOUN
eurjchem-885	105	3	of	of	ADP
eurjchem-885	105	4	its	its	PRON
eurjchem-885	105	5	high	high	ADJ
eurjchem-885	105	6	sensitivity	sensitivity	NOUN
eurjchem-885	105	7	,	,	PUNCT
eurjchem-885	105	8	it	it	PRON
eurjchem-885	105	9	was	be	AUX
eurjchem-885	105	10	applied	apply	VERB
eurjchem-885	105	11	for	for	ADP
eurjchem-885	105	12	the	the	DET
eurjchem-885	105	13	determination	determination	NOUN
eurjchem-885	105	14	of	of	ADP
eurjchem-885	105	15	itc	itc	PROPN
eurjchem-885	105	16	in	in	ADP
eurjchem-885	105	17	human	human	ADJ
eurjchem-885	105	18	plasma	plasma	NOUN
eurjchem-885	105	19	with	with	ADP
eurjchem-885	105	20	no	no	DET
eurjchem-885	105	21	need	need	NOUN
eurjchem-885	105	22	for	for	ADP
eurjchem-885	105	23	tedious	tedious	ADJ
eurjchem-885	105	24	sample	sample	NOUN
eurjchem-885	105	25	pre‐treatment	pre‐treatment	NOUN
eurjchem-885	105	26	steps	step	NOUN
eurjchem-885	105	27	.	.	PUNCT
eurjchem-885	106	1	moreover	moreover	ADV
eurjchem-885	106	2	,	,	PUNCT
eurjchem-885	106	3	it	it	PRON
eurjchem-885	106	4	was	be	AUX
eurjchem-885	106	5	extended	extend	VERB
eurjchem-885	106	6	to	to	PART
eurjchem-885	106	7	investigate	investigate	VERB
eurjchem-885	106	8	the	the	DET
eurjchem-885	106	9	inherent	inherent	ADJ
eurjchem-885	106	10	stability	stability	NOUN
eurjchem-885	106	11	of	of	ADP
eurjchem-885	106	12	itc	itc	PROPN
eurjchem-885	106	13	under	under	ADP
eurjchem-885	106	14	different	different	ADJ
eurjchem-885	106	15	stressed	stressed	ADJ
eurjchem-885	106	16	conditions	condition	NOUN
eurjchem-885	106	17	.	.	PUNCT
eurjchem-885	107	1	different	different	ADJ
eurjchem-885	107	2	parameters	parameter	NOUN
eurjchem-885	107	3	affecting	affect	VERB
eurjchem-885	107	4	the	the	DET
eurjchem-885	107	5	chromatographic	chromatographic	ADJ
eurjchem-885	107	6	performance	performance	NOUN
eurjchem-885	107	7	of	of	ADP
eurjchem-885	107	8	itc	itc	PROPN
eurjchem-885	107	9	were	be	AUX
eurjchem-885	107	10	carefully	carefully	ADV
eurjchem-885	107	11	studied	study	VERB
eurjchem-885	107	12	in	in	ADP
eurjchem-885	107	13	order	order	NOUN
eurjchem-885	107	14	to	to	PART
eurjchem-885	107	15	achieve	achieve	VERB
eurjchem-885	107	16	the	the	DET
eurjchem-885	107	17	most	most	ADV
eurjchem-885	107	18	suitable	suitable	ADJ
eurjchem-885	107	19	chromatographic	chromatographic	ADJ
eurjchem-885	107	20	system	system	NOUN
eurjchem-885	107	21	.	.	PUNCT
eurjchem-885	108	1	the	the	DET
eurjchem-885	108	2	results	result	NOUN
eurjchem-885	108	3	of	of	ADP
eurjchem-885	108	4	the	the	DET
eurjchem-885	108	5	optimization	optimization	NOUN
eurjchem-885	108	6	study	study	NOUN
eurjchem-885	108	7	can	can	AUX
eurjchem-885	108	8	be	be	AUX
eurjchem-885	108	9	summarized	summarize	VERB
eurjchem-885	108	10	as	as	SCONJ
eurjchem-885	108	11	follows	follow	VERB
eurjchem-885	108	12	:	:	PUNCT
eurjchem-885	109	1	3.1	3.1	NUM
eurjchem-885	109	2	.	.	PUNCT
eurjchem-885	109	3	choice	choice	NOUN
eurjchem-885	109	4	of	of	ADP
eurjchem-885	109	5	appropriate	appropriate	ADJ
eurjchem-885	109	6	detection	detection	NOUN
eurjchem-885	109	7	wavelength	wavelength	NOUN
eurjchem-885	109	8	itc	itc	PROPN
eurjchem-885	109	9	exhibits	exhibit	VERB
eurjchem-885	109	10	maximum	maximum	ADJ
eurjchem-885	109	11	absorption	absorption	NOUN
eurjchem-885	109	12	at	at	ADP
eurjchem-885	109	13	258	258	NUM
eurjchem-885	109	14	and	and	CCONJ
eurjchem-885	109	15	262	262	NUM
eurjchem-885	109	16	nm	nm	NOUN
eurjchem-885	109	17	when	when	SCONJ
eurjchem-885	109	18	measured	measure	VERB
eurjchem-885	109	19	in	in	ADP
eurjchem-885	109	20	the	the	DET
eurjchem-885	109	21	mobile	mobile	ADJ
eurjchem-885	109	22	phase	phase	NOUN
eurjchem-885	109	23	and	and	CCONJ
eurjchem-885	109	24	in	in	ADP
eurjchem-885	109	25	methanol	methanol	NOUN
eurjchem-885	109	26	,	,	PUNCT
eurjchem-885	109	27	respectively	respectively	ADV
eurjchem-885	109	28	.	.	PUNCT
eurjchem-885	110	1	so	so	ADV
eurjchem-885	110	2	,	,	PUNCT
eurjchem-885	110	3	258	258	NUM
eurjchem-885	110	4	nm	nm	NOUN
eurjchem-885	110	5	was	be	AUX
eurjchem-885	110	6	selected	select	VERB
eurjchem-885	110	7	as	as	SCONJ
eurjchem-885	110	8	it	it	PRON
eurjchem-885	110	9	gives	give	VERB
eurjchem-885	110	10	reasonable	reasonable	ADJ
eurjchem-885	110	11	sensitivity	sensitivity	NOUN
eurjchem-885	110	12	.	.	PUNCT
eurjchem-885	111	1	the	the	DET
eurjchem-885	111	2	absorption	absorption	NOUN
eurjchem-885	111	3	spectrum	spectrum	NOUN
eurjchem-885	111	4	of	of	ADP
eurjchem-885	111	5	itc	itc	PROPN
eurjchem-885	111	6	in	in	ADP
eurjchem-885	111	7	the	the	DET
eurjchem-885	111	8	micellar	micellar	ADJ
eurjchem-885	111	9	mobile	mobile	ADJ
eurjchem-885	111	10	phase	phase	NOUN
eurjchem-885	111	11	is	be	AUX
eurjchem-885	111	12	shown	show	VERB
eurjchem-885	111	13	in	in	ADP
eurjchem-885	111	14	figure	figure	NOUN
eurjchem-885	111	15	2	2	NUM
eurjchem-885	111	16	.	.	PUNCT
eurjchem-885	111	17	figure	figure	NOUN
eurjchem-885	111	18	2	2	NUM
eurjchem-885	111	19	.	.	PUNCT
eurjchem-885	111	20	absorption	absorption	NOUN
eurjchem-885	111	21	spectrum	spectrum	NOUN
eurjchem-885	111	22	of	of	ADP
eurjchem-885	111	23	itc	itc	PROPN
eurjchem-885	111	24	in	in	ADP
eurjchem-885	111	25	the	the	DET
eurjchem-885	111	26	micellar	micellar	ADJ
eurjchem-885	111	27	mobile	mobile	ADJ
eurjchem-885	111	28	phase	phase	NOUN
eurjchem-885	111	29	.	.	PUNCT
eurjchem-885	112	1	3.2	3.2	NUM
eurjchem-885	112	2	.	.	PUNCT
eurjchem-885	112	3	choice	choice	NOUN
eurjchem-885	112	4	of	of	ADP
eurjchem-885	112	5	column	column	NOUN
eurjchem-885	112	6	to	to	PART
eurjchem-885	112	7	investigate	investigate	VERB
eurjchem-885	112	8	the	the	DET
eurjchem-885	112	9	chromatographic	chromatographic	ADJ
eurjchem-885	112	10	performance	performance	NOUN
eurjchem-885	112	11	,	,	PUNCT
eurjchem-885	112	12	different	different	ADJ
eurjchem-885	112	13	columns	column	NOUN
eurjchem-885	112	14	had	have	AUX
eurjchem-885	112	15	been	be	AUX
eurjchem-885	112	16	tried	try	VERB
eurjchem-885	112	17	,	,	PUNCT
eurjchem-885	112	18	these	these	PRON
eurjchem-885	112	19	include	include	VERB
eurjchem-885	112	20	reversed‐phase	reversed‐phase	PROPN
eurjchem-885	112	21	c8	c8	PROPN
eurjchem-885	112	22	,	,	PUNCT
eurjchem-885	112	23	reversed‐phase	reversed‐phase	NOUN
eurjchem-885	112	24	c18	c18	NOUN
eurjchem-885	112	25	,	,	PUNCT
eurjchem-885	112	26	bonded	bond	VERB
eurjchem-885	112	27	phase	phase	NOUN
eurjchem-885	112	28	cyano	cyano	NOUN
eurjchem-885	112	29	and	and	CCONJ
eurjchem-885	112	30	bonded	bond	VERB
eurjchem-885	112	31	phase	phase	NOUN
eurjchem-885	112	32	phenyl	phenyl	NOUN
eurjchem-885	112	33	columns	column	NOUN
eurjchem-885	112	34	.	.	PUNCT
eurjchem-885	113	1	experimental	experimental	ADJ
eurjchem-885	113	2	trials	trial	NOUN
eurjchem-885	113	3	revealed	reveal	VERB
eurjchem-885	113	4	that	that	SCONJ
eurjchem-885	113	5	the	the	DET
eurjchem-885	113	6	µbondapack	µbondapack	NOUN
eurjchem-885	113	7	cyano	cyano	NOUN
eurjchem-885	113	8	column	column	NOUN
eurjchem-885	113	9	(	(	PUNCT
eurjchem-885	113	10	3.9	3.9	NUM
eurjchem-885	113	11	×	×	NOUN
eurjchem-885	113	12	150	150	NUM
eurjchem-885	113	13	mm	mm	NOUN
eurjchem-885	113	14	,	,	PUNCT
eurjchem-885	113	15	5	5	NUM
eurjchem-885	113	16	µm	µm	ADP
eurjchem-885	113	17	particle	particle	NOUN
eurjchem-885	113	18	size	size	NOUN
eurjchem-885	113	19	)	)	PUNCT
eurjchem-885	113	20	was	be	AUX
eurjchem-885	113	21	the	the	DET
eurjchem-885	113	22	most	most	ADV
eurjchem-885	113	23	suitable	suitable	ADJ
eurjchem-885	113	24	one	one	NUM
eurjchem-885	113	25	giving	give	VERB
eurjchem-885	113	26	narrower	narrow	ADJ
eurjchem-885	113	27	symmetric	symmetric	ADJ
eurjchem-885	113	28	peaks	peak	NOUN
eurjchem-885	113	29	and	and	CCONJ
eurjchem-885	113	30	highest	high	ADJ
eurjchem-885	113	31	number	number	NOUN
eurjchem-885	113	32	of	of	ADP
eurjchem-885	113	33	theoretical	theoretical	ADJ
eurjchem-885	113	34	plates	plate	NOUN
eurjchem-885	113	35	within	within	ADP
eurjchem-885	113	36	a	a	DET
eurjchem-885	113	37	reasonable	reasonable	ADJ
eurjchem-885	113	38	analysis	analysis	NOUN
eurjchem-885	113	39	time	time	NOUN
eurjchem-885	113	40	as	as	SCONJ
eurjchem-885	113	41	shown	show	VERB
eurjchem-885	113	42	in	in	ADP
eurjchem-885	113	43	figure	figure	NOUN
eurjchem-885	113	44	3	3	NUM
eurjchem-885	113	45	and	and	CCONJ
eurjchem-885	113	46	table	table	NOUN
eurjchem-885	113	47	1	1	NUM
eurjchem-885	113	48	.	.	PUNCT
eurjchem-885	113	49	figure	figure	NOUN
eurjchem-885	113	50	3	3	NUM
eurjchem-885	113	51	.	.	PUNCT
eurjchem-885	114	1	itc	itc	PROPN
eurjchem-885	114	2	chromatogram	chromatogram	PROPN
eurjchem-885	114	3	under	under	ADP
eurjchem-885	114	4	optimum	optimum	ADJ
eurjchem-885	114	5	chromatographic	chromatographic	ADJ
eurjchem-885	114	6	conditions	condition	NOUN
eurjchem-885	114	7	using	use	VERB
eurjchem-885	114	8	µbondapack	µbondapack	NOUN
eurjchem-885	114	9	cyano	cyano	NOUN
eurjchem-885	114	10	column	column	NOUN
eurjchem-885	114	11	(	(	PUNCT
eurjchem-885	114	12	a	a	X
eurjchem-885	114	13	)	)	PUNCT
eurjchem-885	114	14	solvent	solvent	ADJ
eurjchem-885	114	15	front	front	ADJ
eurjchem-885	114	16	peak	peak	NOUN
eurjchem-885	114	17	(	(	PUNCT
eurjchem-885	114	18	b	b	NOUN
eurjchem-885	114	19	)	)	PUNCT
eurjchem-885	114	20	itc	itc	PROPN
eurjchem-885	114	21	peak	peak	NOUN
eurjchem-885	114	22	(	(	PUNCT
eurjchem-885	114	23	200	200	NUM
eurjchem-885	114	24	µg	µg	NOUN
eurjchem-885	114	25	/	/	SYM
eurjchem-885	114	26	ml	ml	NOUN
eurjchem-885	114	27	)	)	PUNCT
eurjchem-885	114	28	.	.	PUNCT
eurjchem-885	115	1	3.3	3.3	NUM
eurjchem-885	115	2	.	.	PUNCT
eurjchem-885	115	3	mobile	mobile	ADJ
eurjchem-885	115	4	phase	phase	NOUN
eurjchem-885	115	5	composition	composition	NOUN
eurjchem-885	115	6	to	to	PART
eurjchem-885	115	7	achieve	achieve	VERB
eurjchem-885	115	8	the	the	DET
eurjchem-885	115	9	appropriate	appropriate	ADJ
eurjchem-885	115	10	chromatographic	chromatographic	ADJ
eurjchem-885	115	11	conditions	condition	NOUN
eurjchem-885	115	12	,	,	PUNCT
eurjchem-885	115	13	the	the	DET
eurjchem-885	115	14	mobile	mobile	ADJ
eurjchem-885	115	15	phase	phase	NOUN
eurjchem-885	115	16	composition	composition	NOUN
eurjchem-885	115	17	was	be	AUX
eurjchem-885	115	18	optimized	optimize	VERB
eurjchem-885	115	19	to	to	PART
eurjchem-885	115	20	provide	provide	VERB
eurjchem-885	115	21	sufficient	sufficient	ADJ
eurjchem-885	115	22	selectivity	selectivity	NOUN
eurjchem-885	115	23	and	and	CCONJ
eurjchem-885	115	24	sensitivity	sensitivity	NOUN
eurjchem-885	115	25	in	in	ADP
eurjchem-885	115	26	a	a	DET
eurjchem-885	115	27	short	short	ADJ
eurjchem-885	115	28	separation	separation	NOUN
eurjchem-885	115	29	time	time	NOUN
eurjchem-885	115	30	.	.	PUNCT
eurjchem-885	116	1	the	the	DET
eurjchem-885	116	2	studied	studied	ADJ
eurjchem-885	116	3	variables	variable	NOUN
eurjchem-885	116	4	included	include	VERB
eurjchem-885	116	5	;	;	PUNCT
eurjchem-885	116	6	the	the	DET
eurjchem-885	116	7	ph	ph	NOUN
eurjchem-885	116	8	of	of	ADP
eurjchem-885	116	9	the	the	DET
eurjchem-885	116	10	mobile	mobile	ADJ
eurjchem-885	116	11	phase	phase	NOUN
eurjchem-885	116	12	,	,	PUNCT
eurjchem-885	116	13	flow	flow	NOUN
eurjchem-885	116	14	rate	rate	NOUN
eurjchem-885	116	15	,	,	PUNCT
eurjchem-885	116	16	concentration	concentration	NOUN
eurjchem-885	116	17	of	of	ADP
eurjchem-885	116	18	sds	sds	NOUN
eurjchem-885	116	19	,	,	PUNCT
eurjchem-885	116	20	organic	organic	ADJ
eurjchem-885	116	21	modifier	modifier	NOUN
eurjchem-885	116	22	and	and	CCONJ
eurjchem-885	116	23	tea	tea	NOUN
eurjchem-885	116	24	.	.	PUNCT
eurjchem-885	117	1	the	the	DET
eurjchem-885	117	2	results	result	NOUN
eurjchem-885	117	3	of	of	ADP
eurjchem-885	117	4	such	such	ADJ
eurjchem-885	117	5	optimization	optimization	NOUN
eurjchem-885	117	6	study	study	NOUN
eurjchem-885	117	7	are	be	AUX
eurjchem-885	117	8	presented	present	VERB
eurjchem-885	117	9	in	in	ADP
eurjchem-885	117	10	table	table	NOUN
eurjchem-885	117	11	1	1	NUM
eurjchem-885	117	12	.	.	X
eurjchem-885	118	1	3.3.1	3.3.1	NUM
eurjchem-885	118	2	.	.	X
eurjchem-885	118	3	ph	ph	NOUN
eurjchem-885	118	4	of	of	ADP
eurjchem-885	118	5	the	the	DET
eurjchem-885	118	6	mobile	mobile	ADJ
eurjchem-885	118	7	phase	phase	NOUN
eurjchem-885	118	8	the	the	DET
eurjchem-885	118	9	effect	effect	NOUN
eurjchem-885	118	10	of	of	ADP
eurjchem-885	118	11	ph	ph	NOUN
eurjchem-885	118	12	of	of	ADP
eurjchem-885	118	13	the	the	DET
eurjchem-885	118	14	mobile	mobile	ADJ
eurjchem-885	118	15	phase	phase	NOUN
eurjchem-885	118	16	was	be	AUX
eurjchem-885	118	17	studied	study	VERB
eurjchem-885	118	18	over	over	ADP
eurjchem-885	118	19	the	the	DET
eurjchem-885	118	20	range	range	NOUN
eurjchem-885	118	21	of	of	ADP
eurjchem-885	118	22	2.5‐4.5	2.5‐4.5	NUM
eurjchem-885	118	23	.	.	PUNCT
eurjchem-885	119	1	increasing	increase	VERB
eurjchem-885	119	2	the	the	DET
eurjchem-885	119	3	ph	ph	NOUN
eurjchem-885	119	4	of	of	ADP
eurjchem-885	119	5	the	the	DET
eurjchem-885	119	6	mobile	mobile	ADJ
eurjchem-885	119	7	phase	phase	NOUN
eurjchem-885	119	8	more	more	ADJ
eurjchem-885	119	9	than	than	ADP
eurjchem-885	119	10	3.5	3.5	NUM
eurjchem-885	119	11	caused	cause	VERB
eurjchem-885	119	12	increase	increase	NOUN
eurjchem-885	119	13	in	in	ADP
eurjchem-885	119	14	the	the	DET
eurjchem-885	119	15	retention	retention	NOUN
eurjchem-885	119	16	time	time	NOUN
eurjchem-885	119	17	of	of	ADP
eurjchem-885	119	18	itc	itc	PROPN
eurjchem-885	119	19	.	.	PUNCT
eurjchem-885	120	1	therefore	therefore	ADV
eurjchem-885	120	2	,	,	PUNCT
eurjchem-885	120	3	ph	ph	PROPN
eurjchem-885	120	4	=	=	SYM
eurjchem-885	120	5	3.5	3.5	NUM
eurjchem-885	120	6	was	be	AUX
eurjchem-885	120	7	selected	select	VERB
eurjchem-885	120	8	as	as	ADP
eurjchem-885	120	9	the	the	DET
eurjchem-885	120	10	optimum	optimum	ADJ
eurjchem-885	120	11	ph	ph	NOUN
eurjchem-885	120	12	value	value	NOUN
eurjchem-885	120	13	for	for	ADP
eurjchem-885	120	14	the	the	DET
eurjchem-885	120	15	mobile	mobile	ADJ
eurjchem-885	120	16	phase	phase	NOUN
eurjchem-885	120	17	yielding	yield	VERB
eurjchem-885	120	18	highest	high	ADJ
eurjchem-885	120	19	number	number	NOUN
eurjchem-885	120	20	of	of	ADP
eurjchem-885	120	21	theoretical	theoretical	ADJ
eurjchem-885	120	22	plates	plate	NOUN
eurjchem-885	120	23	with	with	ADP
eurjchem-885	120	24	good	good	ADJ
eurjchem-885	120	25	peak	peak	NOUN
eurjchem-885	120	26	shape	shape	NOUN
eurjchem-885	120	27	and	and	CCONJ
eurjchem-885	120	28	lowest	low	ADJ
eurjchem-885	120	29	peak	peak	NOUN
eurjchem-885	120	30	tailing	tailing	NOUN
eurjchem-885	120	31	.	.	PUNCT
eurjchem-885	121	1	3.3.2	3.3.2	X
eurjchem-885	121	2	.	.	PUNCT
eurjchem-885	121	3	concentration	concentration	NOUN
eurjchem-885	121	4	of	of	ADP
eurjchem-885	121	5	sds	sds	PROPN
eurjchem-885	121	6	sds	sds	PROPN
eurjchem-885	121	7	concentration	concentration	NOUN
eurjchem-885	121	8	was	be	AUX
eurjchem-885	121	9	varied	varied	ADJ
eurjchem-885	121	10	over	over	ADP
eurjchem-885	121	11	the	the	DET
eurjchem-885	121	12	range	range	NOUN
eurjchem-885	121	13	of	of	ADP
eurjchem-885	121	14	0.07‐0.10	0.07‐0.10	NUM
eurjchem-885	121	15	m.	m.	NOUN
eurjchem-885	121	16	mobile	mobile	ADJ
eurjchem-885	121	17	phase	phase	NOUN
eurjchem-885	121	18	containing	contain	VERB
eurjchem-885	121	19	0.07	0.07	NUM
eurjchem-885	121	20	m	m	NOUN
eurjchem-885	121	21	sds	sds	NOUN
eurjchem-885	121	22	resulted	result	VERB
eurjchem-885	121	23	in	in	ADP
eurjchem-885	121	24	very	very	ADV
eurjchem-885	121	25	broad	broad	ADJ
eurjchem-885	121	26	peak	peak	NOUN
eurjchem-885	121	27	.	.	PUNCT
eurjchem-885	122	1	the	the	DET
eurjchem-885	122	2	retention	retention	NOUN
eurjchem-885	122	3	time	time	NOUN
eurjchem-885	122	4	of	of	ADP
eurjchem-885	122	5	the	the	DET
eurjchem-885	122	6	drug	drug	NOUN
eurjchem-885	122	7	decreased	decrease	VERB
eurjchem-885	122	8	as	as	SCONJ
eurjchem-885	122	9	the	the	DET
eurjchem-885	122	10	molar	molar	ADJ
eurjchem-885	122	11	concentration	concentration	NOUN
eurjchem-885	122	12	of	of	ADP
eurjchem-885	122	13	sds	sds	PROPN
eurjchem-885	122	14	increased	increase	VERB
eurjchem-885	122	15	.	.	PUNCT
eurjchem-885	123	1	14	14	NUM
eurjchem-885	123	2	rizk	rizk	PROPN
eurjchem-885	123	3	et	et	PROPN
eurjchem-885	123	4	al	al	PROPN
eurjchem-885	123	5	.	.	PUNCT
eurjchem-885	123	6	/	/	SYM
eurjchem-885	123	7	european	european	PROPN
eurjchem-885	123	8	journal	journal	PROPN
eurjchem-885	123	9	of	of	ADP
eurjchem-885	123	10	chemistry	chemistry	NOUN
eurjchem-885	123	11	5	5	NUM
eurjchem-885	123	12	(	(	PUNCT
eurjchem-885	123	13	1	1	NUM
eurjchem-885	123	14	)	)	PUNCT
eurjchem-885	123	15	(	(	PUNCT
eurjchem-885	123	16	2014	2014	NUM
eurjchem-885	123	17	)	)	PUNCT
eurjchem-885	123	18	11‐17	11‐17	ADJ
eurjchem-885	123	19	table	table	NOUN
eurjchem-885	123	20	2	2	NUM
eurjchem-885	123	21	.	.	PUNCT
eurjchem-885	123	22	accuracy	accuracy	NOUN
eurjchem-885	123	23	of	of	ADP
eurjchem-885	123	24	the	the	DET
eurjchem-885	123	25	proposed	propose	VERB
eurjchem-885	123	26	mlc	mlc	NOUN
eurjchem-885	123	27	method	method	NOUN
eurjchem-885	123	28	for	for	ADP
eurjchem-885	123	29	the	the	DET
eurjchem-885	123	30	determination	determination	NOUN
eurjchem-885	123	31	of	of	ADP
eurjchem-885	123	32	itc	itc	PROPN
eurjchem-885	123	33	.	.	PUNCT
eurjchem-885	123	34	parameter	parameter	PROPN
eurjchem-885	123	35	proposed	propose	VERB
eurjchem-885	123	36	method	method	PROPN
eurjchem-885	123	37	comparison	comparison	NOUN
eurjchem-885	123	38	method	method	NOUN
eurjchem-885	123	39	[	[	X
eurjchem-885	123	40	2	2	NUM
eurjchem-885	123	41	]	]	PUNCT
eurjchem-885	123	42	conc	conc	NOUN
eurjchem-885	123	43	.	.	PUNCT
eurjchem-885	124	1	taken	take	VERB
eurjchem-885	124	2	(	(	PUNCT
eurjchem-885	124	3	µg	µg	NOUN
eurjchem-885	124	4	/	/	SYM
eurjchem-885	124	5	ml	ml	NOUN
eurjchem-885	124	6	)	)	PUNCT
eurjchem-885	124	7	conc	conc	NOUN
eurjchem-885	124	8	.	.	PUNCT
eurjchem-885	125	1	found	find	VERB
eurjchem-885	125	2	(	(	PUNCT
eurjchem-885	125	3	µg	µg	ADJ
eurjchem-885	125	4	/	/	SYM
eurjchem-885	125	5	ml	ml	NOUN
eurjchem-885	125	6	)	)	PUNCT
eurjchem-885	125	7	%	%	NOUN
eurjchem-885	125	8	found	find	VERB
eurjchem-885	125	9	*	*	PUNCT
eurjchem-885	125	10	%	%	INTJ
eurjchem-885	125	11	found	find	VERB
eurjchem-885	125	12	*	*	PUNCT
eurjchem-885	125	13	120	120	NUM
eurjchem-885	125	14	121.6	121.6	NUM
eurjchem-885	125	15	101.3	101.3	NUM
eurjchem-885	125	16	100.9	100.9	NUM
eurjchem-885	125	17	160	160	NUM
eurjchem-885	125	18	157.2	157.2	NUM
eurjchem-885	125	19	98.3	98.3	NUM
eurjchem-885	125	20	99.1	99.1	NUM
eurjchem-885	125	21	200	200	NUM
eurjchem-885	125	22	200.9	200.9	NUM
eurjchem-885	125	23	100.5	100.5	NUM
eurjchem-885	125	24	102.0	102.0	NUM
eurjchem-885	125	25	240	240	NUM
eurjchem-885	125	26	240.3	240.3	NUM
eurjchem-885	125	27	100.1	100.1	NUM
eurjchem-885	125	28	100.2	100.2	NUM
eurjchem-885	125	29	320	320	NUM
eurjchem-885	125	30	319.9	319.9	NUM
eurjchem-885	125	31	100.0	100.0	NUM
eurjchem-885	125	32	99.2	99.2	NUM
eurjchem-885	125	33	x±sd	x±sd	ADP
eurjchem-885	125	34	100.04±1.1	100.04±1.1	NUM
eurjchem-885	126	1	100.3±1.2	100.3±1.2	NUM
eurjchem-885	126	2	t	t	PROPN
eurjchem-885	126	3	0.3	0.3	NUM
eurjchem-885	126	4	(	(	PUNCT
eurjchem-885	126	5	1.9	1.9	NUM
eurjchem-885	126	6	)	)	PUNCT
eurjchem-885	126	7	*	*	PUNCT
eurjchem-885	127	1	*	*	PUNCT
eurjchem-885	127	2	f	f	X
eurjchem-885	127	3	1.2	1.2	NUM
eurjchem-885	127	4	(	(	PUNCT
eurjchem-885	127	5	6.4	6.4	NUM
eurjchem-885	127	6	)	)	PUNCT
eurjchem-885	127	7	*	*	PUNCT
eurjchem-885	128	1	*	*	PUNCT
eurjchem-885	128	2	*	*	PUNCT
eurjchem-885	128	3	each	each	DET
eurjchem-885	128	4	result	result	NOUN
eurjchem-885	128	5	is	be	AUX
eurjchem-885	128	6	the	the	DET
eurjchem-885	128	7	average	average	NOUN
eurjchem-885	128	8	of	of	ADP
eurjchem-885	128	9	three	three	NUM
eurjchem-885	128	10	separate	separate	ADJ
eurjchem-885	128	11	determinations	determination	NOUN
eurjchem-885	128	12	.	.	PUNCT
eurjchem-885	129	1	*	*	PUNCT
eurjchem-885	129	2	*	*	PUNCT
eurjchem-885	129	3	values	value	NOUN
eurjchem-885	129	4	between	between	ADP
eurjchem-885	129	5	parentheses	parenthesis	NOUN
eurjchem-885	129	6	are	be	AUX
eurjchem-885	129	7	the	the	DET
eurjchem-885	129	8	tabulated	tabulate	VERB
eurjchem-885	129	9	t	t	NOUN
eurjchem-885	129	10	and	and	CCONJ
eurjchem-885	129	11	f	f	PROPN
eurjchem-885	129	12	values	value	NOUN
eurjchem-885	129	13	at	at	ADP
eurjchem-885	129	14	n	n	NOUN
eurjchem-885	129	15	=	=	SYM
eurjchem-885	129	16	15	15	NUM
eurjchem-885	129	17	and	and	CCONJ
eurjchem-885	129	18	p	p	X
eurjchem-885	129	19	=	=	NOUN
eurjchem-885	129	20	0.05	0.05	NUM
eurjchem-885	129	21	[	[	X
eurjchem-885	129	22	26	26	NUM
eurjchem-885	129	23	]	]	PUNCT
eurjchem-885	129	24	.	.	PUNCT
eurjchem-885	130	1	the	the	DET
eurjchem-885	130	2	best	good	ADJ
eurjchem-885	130	3	compromise	compromise	NOUN
eurjchem-885	130	4	in	in	ADP
eurjchem-885	130	5	terms	term	NOUN
eurjchem-885	130	6	of	of	ADP
eurjchem-885	130	7	run	run	NOUN
eurjchem-885	130	8	time	time	NOUN
eurjchem-885	130	9	,	,	PUNCT
eurjchem-885	130	10	efficiency	efficiency	NOUN
eurjchem-885	130	11	and	and	CCONJ
eurjchem-885	130	12	peak	peak	NOUN
eurjchem-885	130	13	symmetry	symmetry	NOUN
eurjchem-885	130	14	was	be	AUX
eurjchem-885	130	15	achieved	achieve	VERB
eurjchem-885	130	16	upon	upon	SCONJ
eurjchem-885	130	17	using	use	VERB
eurjchem-885	130	18	a	a	DET
eurjchem-885	130	19	mobile	mobile	ADJ
eurjchem-885	130	20	phase	phase	NOUN
eurjchem-885	130	21	containing	contain	VERB
eurjchem-885	130	22	0.10	0.10	NUM
eurjchem-885	130	23	m	m	NOUN
eurjchem-885	130	24	sds	sds	NOUN
eurjchem-885	130	25	.	.	PUNCT
eurjchem-885	131	1	3.3.3	3.3.3	X
eurjchem-885	131	2	.	.	PUNCT
eurjchem-885	132	1	concentration	concentration	NOUN
eurjchem-885	132	2	of	of	ADP
eurjchem-885	132	3	organic	organic	ADJ
eurjchem-885	132	4	modifier	modifier	NOUN
eurjchem-885	132	5	concentration	concentration	NOUN
eurjchem-885	132	6	of	of	ADP
eurjchem-885	132	7	1‐propanol	1‐propanol	NUM
eurjchem-885	132	8	was	be	AUX
eurjchem-885	132	9	varied	varied	ADJ
eurjchem-885	132	10	over	over	ADP
eurjchem-885	132	11	the	the	DET
eurjchem-885	132	12	range	range	NOUN
eurjchem-885	132	13	of	of	ADP
eurjchem-885	132	14	10‐20	10‐20	NUM
eurjchem-885	132	15	%	%	NOUN
eurjchem-885	132	16	.	.	PUNCT
eurjchem-885	133	1	as	as	SCONJ
eurjchem-885	133	2	expected	expect	VERB
eurjchem-885	133	3	,	,	PUNCT
eurjchem-885	133	4	the	the	DET
eurjchem-885	133	5	retention	retention	NOUN
eurjchem-885	133	6	of	of	ADP
eurjchem-885	133	7	itc	itc	PROPN
eurjchem-885	133	8	decreases	decrease	NOUN
eurjchem-885	133	9	as	as	ADP
eurjchem-885	133	10	percentage	percentage	NOUN
eurjchem-885	133	11	of	of	ADP
eurjchem-885	133	12	organic	organic	ADJ
eurjchem-885	133	13	modifier	modifier	NOUN
eurjchem-885	133	14	increases	increase	NOUN
eurjchem-885	133	15	.	.	PUNCT
eurjchem-885	134	1	in	in	ADP
eurjchem-885	134	2	addition	addition	NOUN
eurjchem-885	134	3	,	,	PUNCT
eurjchem-885	134	4	peak	peak	NOUN
eurjchem-885	134	5	broadening	broadening	NOUN
eurjchem-885	134	6	was	be	AUX
eurjchem-885	134	7	observed	observe	VERB
eurjchem-885	134	8	at	at	ADP
eurjchem-885	134	9	low	low	ADJ
eurjchem-885	134	10	concentrations	concentration	NOUN
eurjchem-885	134	11	of	of	ADP
eurjchem-885	134	12	1‐propanol	1‐propanol	NOUN
eurjchem-885	134	13	.	.	PUNCT
eurjchem-885	135	1	a	a	DET
eurjchem-885	135	2	concentration	concentration	NOUN
eurjchem-885	135	3	of	of	ADP
eurjchem-885	135	4	20	20	NUM
eurjchem-885	135	5	%	%	NOUN
eurjchem-885	135	6	of	of	ADP
eurjchem-885	135	7	1‐propanol	1‐propanol	NUM
eurjchem-885	135	8	was	be	AUX
eurjchem-885	135	9	chosen	choose	VERB
eurjchem-885	135	10	as	as	ADP
eurjchem-885	135	11	the	the	DET
eurjchem-885	135	12	optimal	optimal	ADJ
eurjchem-885	135	13	concentration	concentration	NOUN
eurjchem-885	135	14	,	,	PUNCT
eurjchem-885	135	15	where	where	SCONJ
eurjchem-885	135	16	it	it	PRON
eurjchem-885	135	17	offers	offer	VERB
eurjchem-885	135	18	a	a	DET
eurjchem-885	135	19	good	good	ADJ
eurjchem-885	135	20	combination	combination	NOUN
eurjchem-885	135	21	of	of	ADP
eurjchem-885	135	22	peak	peak	NOUN
eurjchem-885	135	23	symmetry	symmetry	NOUN
eurjchem-885	135	24	and	and	CCONJ
eurjchem-885	135	25	analysis	analysis	NOUN
eurjchem-885	135	26	time	time	NOUN
eurjchem-885	135	27	.	.	PUNCT
eurjchem-885	136	1	zero	zero	NUM
eurjchem-885	136	2	concentration	concentration	NOUN
eurjchem-885	136	3	of	of	ADP
eurjchem-885	136	4	propanol	propanol	NOUN
eurjchem-885	136	5	was	be	AUX
eurjchem-885	136	6	tried	try	VERB
eurjchem-885	136	7	and	and	CCONJ
eurjchem-885	136	8	no	no	DET
eurjchem-885	136	9	peak	peak	NOUN
eurjchem-885	136	10	appears	appear	VERB
eurjchem-885	136	11	till	till	SCONJ
eurjchem-885	136	12	20	20	NUM
eurjchem-885	136	13	min	min	NOUN
eurjchem-885	136	14	.	.	PROPN
eurjchem-885	136	15	3.3.4	3.3.4	NUM
eurjchem-885	136	16	.	.	PUNCT
eurjchem-885	137	1	concentration	concentration	NOUN
eurjchem-885	137	2	of	of	ADP
eurjchem-885	137	3	triethyl	triethyl	PROPN
eurjchem-885	137	4	amine	amine	PROPN
eurjchem-885	137	5	(	(	PUNCT
eurjchem-885	137	6	tea	tea	NOUN
eurjchem-885	137	7	)	)	PUNCT
eurjchem-885	137	8	tea	tea	NOUN
eurjchem-885	137	9	is	be	AUX
eurjchem-885	137	10	added	add	VERB
eurjchem-885	137	11	to	to	ADP
eurjchem-885	137	12	the	the	DET
eurjchem-885	137	13	mobile	mobile	ADJ
eurjchem-885	137	14	phase	phase	NOUN
eurjchem-885	137	15	to	to	PART
eurjchem-885	137	16	bind	bind	VERB
eurjchem-885	137	17	the	the	DET
eurjchem-885	137	18	silanol	silanol	NOUN
eurjchem-885	137	19	groups	group	NOUN
eurjchem-885	137	20	.	.	PUNCT
eurjchem-885	138	1	this	this	PRON
eurjchem-885	138	2	reduces	reduce	VERB
eurjchem-885	138	3	the	the	DET
eurjchem-885	138	4	tailing	tailing	NOUN
eurjchem-885	138	5	of	of	ADP
eurjchem-885	138	6	basic	basic	ADJ
eurjchem-885	138	7	compounds	compound	NOUN
eurjchem-885	138	8	which	which	PRON
eurjchem-885	138	9	is	be	AUX
eurjchem-885	138	10	not	not	PART
eurjchem-885	138	11	due	due	ADJ
eurjchem-885	138	12	to	to	ADP
eurjchem-885	138	13	the	the	DET
eurjchem-885	138	14	micellar	micellar	ADJ
eurjchem-885	138	15	phase	phase	NOUN
eurjchem-885	138	16	.	.	PUNCT
eurjchem-885	139	1	to	to	PART
eurjchem-885	139	2	study	study	VERB
eurjchem-885	139	3	the	the	DET
eurjchem-885	139	4	influence	influence	NOUN
eurjchem-885	139	5	of	of	ADP
eurjchem-885	139	6	the	the	DET
eurjchem-885	139	7	concentration	concentration	NOUN
eurjchem-885	139	8	of	of	ADP
eurjchem-885	139	9	tea	tea	NOUN
eurjchem-885	139	10	on	on	ADP
eurjchem-885	139	11	the	the	DET
eurjchem-885	139	12	peak	peak	NOUN
eurjchem-885	139	13	of	of	ADP
eurjchem-885	139	14	itc	itc	PROPN
eurjchem-885	139	15	,	,	PUNCT
eurjchem-885	139	16	it	it	PRON
eurjchem-885	139	17	was	be	AUX
eurjchem-885	139	18	varied	varied	ADJ
eurjchem-885	139	19	over	over	ADP
eurjchem-885	139	20	the	the	DET
eurjchem-885	139	21	range	range	NOUN
eurjchem-885	139	22	of	of	ADP
eurjchem-885	139	23	0.2‐	0.2‐	NUM
eurjchem-885	139	24	0.3	0.3	NUM
eurjchem-885	139	25	%	%	NOUN
eurjchem-885	139	26	.	.	PUNCT
eurjchem-885	140	1	it	it	PRON
eurjchem-885	140	2	was	be	AUX
eurjchem-885	140	3	found	find	VERB
eurjchem-885	140	4	that	that	SCONJ
eurjchem-885	140	5	the	the	DET
eurjchem-885	140	6	peak	peak	NOUN
eurjchem-885	140	7	tailing	tailing	NOUN
eurjchem-885	140	8	,	,	PUNCT
eurjchem-885	140	9	peak	peak	NOUN
eurjchem-885	140	10	asymmetry	asymmetry	NOUN
eurjchem-885	140	11	and	and	CCONJ
eurjchem-885	140	12	number	number	NOUN
eurjchem-885	140	13	of	of	ADP
eurjchem-885	140	14	theoretical	theoretical	ADJ
eurjchem-885	140	15	plates	plate	NOUN
eurjchem-885	140	16	are	be	AUX
eurjchem-885	140	17	better	well	ADJ
eurjchem-885	140	18	with	with	ADP
eurjchem-885	140	19	0.3	0.3	NUM
eurjchem-885	140	20	%	%	NOUN
eurjchem-885	140	21	tea	tea	NOUN
eurjchem-885	140	22	.	.	PUNCT
eurjchem-885	141	1	the	the	DET
eurjchem-885	141	2	recorded	record	VERB
eurjchem-885	141	3	performance	performance	NOUN
eurjchem-885	141	4	parameters	parameter	NOUN
eurjchem-885	141	5	were	be	AUX
eurjchem-885	141	6	listed	list	VERB
eurjchem-885	141	7	in	in	ADP
eurjchem-885	141	8	table	table	NOUN
eurjchem-885	141	9	1	1	NUM
eurjchem-885	141	10	.	.	X
eurjchem-885	142	1	3.3.5	3.3.5	X
eurjchem-885	142	2	.	.	PUNCT
eurjchem-885	143	1	flow	flow	NOUN
eurjchem-885	143	2	rate	rate	NOUN
eurjchem-885	143	3	of	of	ADP
eurjchem-885	143	4	the	the	DET
eurjchem-885	143	5	mobile	mobile	ADJ
eurjchem-885	143	6	phase	phase	NOUN
eurjchem-885	143	7	the	the	DET
eurjchem-885	143	8	effect	effect	NOUN
eurjchem-885	143	9	of	of	ADP
eurjchem-885	143	10	flow	flow	NOUN
eurjchem-885	143	11	rate	rate	NOUN
eurjchem-885	143	12	of	of	ADP
eurjchem-885	143	13	the	the	DET
eurjchem-885	143	14	mobile	mobile	ADJ
eurjchem-885	143	15	phase	phase	NOUN
eurjchem-885	143	16	on	on	ADP
eurjchem-885	143	17	the	the	DET
eurjchem-885	143	18	retention	retention	NOUN
eurjchem-885	143	19	of	of	ADP
eurjchem-885	143	20	itc	itc	PROPN
eurjchem-885	143	21	was	be	AUX
eurjchem-885	143	22	investigated	investigate	VERB
eurjchem-885	143	23	over	over	ADP
eurjchem-885	143	24	the	the	DET
eurjchem-885	143	25	range	range	NOUN
eurjchem-885	143	26	of	of	ADP
eurjchem-885	143	27	1.0‐2.0	1.0‐2.0	NUM
eurjchem-885	143	28	ml	ml	PROPN
eurjchem-885	143	29	/	/	SYM
eurjchem-885	143	30	min	min	PROPN
eurjchem-885	143	31	.	.	PROPN
eurjchem-885	143	32	flow	flow	NOUN
eurjchem-885	143	33	rate	rate	NOUN
eurjchem-885	143	34	of	of	ADP
eurjchem-885	143	35	2.0	2.0	NUM
eurjchem-885	143	36	ml	ml	NOUN
eurjchem-885	143	37	/	/	SYM
eurjchem-885	143	38	min	min	NOUN
eurjchem-885	143	39	was	be	AUX
eurjchem-885	143	40	chosen	choose	VERB
eurjchem-885	143	41	since	since	SCONJ
eurjchem-885	143	42	it	it	PRON
eurjchem-885	143	43	provides	provide	VERB
eurjchem-885	143	44	better	well	ADJ
eurjchem-885	143	45	peak	peak	NOUN
eurjchem-885	143	46	shape	shape	NOUN
eurjchem-885	143	47	within	within	ADP
eurjchem-885	143	48	a	a	DET
eurjchem-885	143	49	reasonable	reasonable	ADJ
eurjchem-885	143	50	time	time	NOUN
eurjchem-885	143	51	.	.	PUNCT
eurjchem-885	144	1	after	after	ADP
eurjchem-885	144	2	optimization	optimization	NOUN
eurjchem-885	144	3	of	of	ADP
eurjchem-885	144	4	these	these	DET
eurjchem-885	144	5	variables	variable	NOUN
eurjchem-885	144	6	,	,	PUNCT
eurjchem-885	144	7	best	good	ADJ
eurjchem-885	144	8	peak	peak	NOUN
eurjchem-885	144	9	shape	shape	NOUN
eurjchem-885	144	10	and	and	CCONJ
eurjchem-885	144	11	lowest	low	ADJ
eurjchem-885	144	12	peak	peak	NOUN
eurjchem-885	144	13	tailing	tailing	NOUN
eurjchem-885	144	14	were	be	AUX
eurjchem-885	144	15	achieved	achieve	VERB
eurjchem-885	144	16	with	with	ADP
eurjchem-885	144	17	well‐defined	well‐defined	ADJ
eurjchem-885	144	18	peaks	peak	NOUN
eurjchem-885	144	19	and	and	CCONJ
eurjchem-885	144	20	good	good	ADJ
eurjchem-885	144	21	sensitivity	sensitivity	NOUN
eurjchem-885	144	22	within	within	ADP
eurjchem-885	144	23	a	a	DET
eurjchem-885	144	24	reasonable	reasonable	ADJ
eurjchem-885	144	25	analytical	analytical	ADJ
eurjchem-885	144	26	run	run	NOUN
eurjchem-885	144	27	time	time	NOUN
eurjchem-885	144	28	.	.	PUNCT
eurjchem-885	145	1	figure	figure	NOUN
eurjchem-885	145	2	3	3	NUM
eurjchem-885	145	3	represents	represent	VERB
eurjchem-885	145	4	a	a	DET
eurjchem-885	145	5	chromatogram	chromatogram	NOUN
eurjchem-885	145	6	indicating	indicate	VERB
eurjchem-885	145	7	the	the	DET
eurjchem-885	145	8	good	good	ADJ
eurjchem-885	145	9	retention	retention	NOUN
eurjchem-885	145	10	of	of	ADP
eurjchem-885	145	11	itc	itc	PROPN
eurjchem-885	145	12	under	under	ADP
eurjchem-885	145	13	the	the	DET
eurjchem-885	145	14	optimum	optimum	ADJ
eurjchem-885	145	15	chromatographic	chromatographic	ADJ
eurjchem-885	145	16	conditions	condition	NOUN
eurjchem-885	145	17	.	.	PUNCT
eurjchem-885	146	1	3.4	3.4	NUM
eurjchem-885	146	2	.	.	PUNCT
eurjchem-885	146	3	method	method	NOUN
eurjchem-885	146	4	validation	validation	NOUN
eurjchem-885	146	5	the	the	DET
eurjchem-885	146	6	validity	validity	NOUN
eurjchem-885	146	7	of	of	ADP
eurjchem-885	146	8	the	the	DET
eurjchem-885	146	9	proposed	propose	VERB
eurjchem-885	146	10	method	method	NOUN
eurjchem-885	146	11	was	be	AUX
eurjchem-885	146	12	assessed	assess	VERB
eurjchem-885	146	13	by	by	ADP
eurjchem-885	146	14	studying	study	VERB
eurjchem-885	146	15	the	the	DET
eurjchem-885	146	16	following	follow	VERB
eurjchem-885	146	17	parameters	parameter	NOUN
eurjchem-885	146	18	in	in	ADP
eurjchem-885	146	19	accordance	accordance	NOUN
eurjchem-885	146	20	to	to	ADP
eurjchem-885	146	21	ich	ich	NOUN
eurjchem-885	146	22	guideline	guideline	NOUN
eurjchem-885	147	1	[	[	X
eurjchem-885	147	2	25	25	NUM
eurjchem-885	147	3	]	]	NOUN
eurjchem-885	147	4	:	:	PUNCT
eurjchem-885	147	5	linearity	linearity	PROPN
eurjchem-885	147	6	,	,	PUNCT
eurjchem-885	147	7	lod	lod	PROPN
eurjchem-885	147	8	,	,	PUNCT
eurjchem-885	147	9	loq	loq	PROPN
eurjchem-885	147	10	,	,	PUNCT
eurjchem-885	147	11	accuracy	accuracy	NOUN
eurjchem-885	147	12	,	,	PUNCT
eurjchem-885	147	13	precision	precision	NOUN
eurjchem-885	147	14	,	,	PUNCT
eurjchem-885	147	15	selectivity	selectivity	NOUN
eurjchem-885	147	16	,	,	PUNCT
eurjchem-885	147	17	sample	sample	NOUN
eurjchem-885	147	18	solution	solution	NOUN
eurjchem-885	147	19	stability	stability	NOUN
eurjchem-885	147	20	,	,	PUNCT
eurjchem-885	147	21	mobile	mobile	ADJ
eurjchem-885	147	22	phase	phase	NOUN
eurjchem-885	147	23	stability	stability	NOUN
eurjchem-885	147	24	,	,	PUNCT
eurjchem-885	147	25	system	system	NOUN
eurjchem-885	147	26	suitability	suitability	NOUN
eurjchem-885	147	27	and	and	CCONJ
eurjchem-885	147	28	robustness	robustness	NOUN
eurjchem-885	147	29	.	.	PUNCT
eurjchem-885	148	1	3.4.1	3.4.1	X
eurjchem-885	148	2	.	.	X
eurjchem-885	148	3	linearity	linearity	NOUN
eurjchem-885	148	4	under	under	ADP
eurjchem-885	148	5	the	the	DET
eurjchem-885	148	6	optimum	optimum	ADJ
eurjchem-885	148	7	chromatographic	chromatographic	ADJ
eurjchem-885	148	8	conditions	condition	NOUN
eurjchem-885	148	9	,	,	PUNCT
eurjchem-885	148	10	a	a	DET
eurjchem-885	148	11	linear	linear	ADJ
eurjchem-885	148	12	relationship	relationship	NOUN
eurjchem-885	148	13	was	be	AUX
eurjchem-885	148	14	established	establish	VERB
eurjchem-885	148	15	over	over	ADP
eurjchem-885	148	16	the	the	DET
eurjchem-885	148	17	concentration	concentration	NOUN
eurjchem-885	148	18	ranges	range	NOUN
eurjchem-885	148	19	of	of	ADP
eurjchem-885	148	20	16.4‐320.0	16.4‐320.0	PROPN
eurjchem-885	148	21	µg	µg	NOUN
eurjchem-885	148	22	/	/	SYM
eurjchem-885	148	23	ml	ml	PROPN
eurjchem-885	148	24	itc	itc	PROPN
eurjchem-885	148	25	(	(	PUNCT
eurjchem-885	148	26	figure	figure	NOUN
eurjchem-885	148	27	4	4	NUM
eurjchem-885	148	28	)	)	PUNCT
eurjchem-885	148	29	with	with	ADP
eurjchem-885	148	30	good	good	ADJ
eurjchem-885	148	31	correlation	correlation	NOUN
eurjchem-885	148	32	coefficient	coefficient	NOUN
eurjchem-885	148	33	(	(	PUNCT
eurjchem-885	148	34	r	r	NOUN
eurjchem-885	148	35	)	)	PUNCT
eurjchem-885	148	36	and	and	CCONJ
eurjchem-885	148	37	relative	relative	ADJ
eurjchem-885	148	38	standard	standard	ADJ
eurjchem-885	148	39	deviation	deviation	NOUN
eurjchem-885	148	40	(	(	PUNCT
eurjchem-885	148	41	r.s.d	r.s.d	NOUN
eurjchem-885	148	42	.	.	PUNCT
eurjchem-885	148	43	)	)	PUNCT
eurjchem-885	149	1	(	(	PUNCT
eurjchem-885	149	2	1.05	1.05	NUM
eurjchem-885	149	3	%	%	NOUN
eurjchem-885	149	4	)	)	PUNCT
eurjchem-885	150	1	according	accord	VERB
eurjchem-885	150	2	to	to	ADP
eurjchem-885	150	3	the	the	DET
eurjchem-885	150	4	following	follow	VERB
eurjchem-885	150	5	regression	regression	NOUN
eurjchem-885	150	6	equation	equation	NOUN
eurjchem-885	150	7	:	:	PUNCT
eurjchem-885	150	8	y	y	PROPN
eurjchem-885	150	9	=	=	SYM
eurjchem-885	150	10	15545	15545	NUM
eurjchem-885	150	11	x	x	SYM
eurjchem-885	150	12	–	–	PUNCT
eurjchem-885	150	13	40170	40170	NUM
eurjchem-885	150	14	(	(	PUNCT
eurjchem-885	150	15	r	r	NOUN
eurjchem-885	150	16	=	=	SYM
eurjchem-885	150	17	0.9997	0.9997	NUM
eurjchem-885	150	18	)	)	PUNCT
eurjchem-885	150	19	(	(	PUNCT
eurjchem-885	150	20	1	1	X
eurjchem-885	150	21	)	)	PUNCT
eurjchem-885	150	22	limit	limit	NOUN
eurjchem-885	150	23	of	of	ADP
eurjchem-885	150	24	detection	detection	NOUN
eurjchem-885	150	25	(	(	PUNCT
eurjchem-885	150	26	lod	lod	PROPN
eurjchem-885	150	27	)	)	PUNCT
eurjchem-885	150	28	(	(	PUNCT
eurjchem-885	150	29	the	the	DET
eurjchem-885	150	30	lowest	low	ADJ
eurjchem-885	150	31	concentration	concentration	NOUN
eurjchem-885	150	32	that	that	PRON
eurjchem-885	150	33	can	can	AUX
eurjchem-885	150	34	be	be	AUX
eurjchem-885	150	35	determined	determine	VERB
eurjchem-885	150	36	)	)	PUNCT
eurjchem-885	150	37	and	and	CCONJ
eurjchem-885	150	38	limit	limit	NOUN
eurjchem-885	150	39	of	of	ADP
eurjchem-885	150	40	quantification	quantification	NOUN
eurjchem-885	150	41	(	(	PUNCT
eurjchem-885	150	42	loq	loq	PROPN
eurjchem-885	150	43	)	)	PUNCT
eurjchem-885	150	44	(	(	PUNCT
eurjchem-885	150	45	the	the	DET
eurjchem-885	150	46	lowest	low	ADJ
eurjchem-885	150	47	concentration	concentration	NOUN
eurjchem-885	150	48	of	of	ADP
eurjchem-885	150	49	a	a	DET
eurjchem-885	150	50	substance	substance	NOUN
eurjchem-885	150	51	that	that	PRON
eurjchem-885	150	52	can	can	AUX
eurjchem-885	150	53	be	be	AUX
eurjchem-885	150	54	quantified	quantify	VERB
eurjchem-885	150	55	with	with	ADP
eurjchem-885	150	56	acceptable	acceptable	ADJ
eurjchem-885	150	57	precision	precision	NOUN
eurjchem-885	150	58	and	and	CCONJ
eurjchem-885	150	59	accuracy	accuracy	NOUN
eurjchem-885	150	60	)	)	PUNCT
eurjchem-885	150	61	for	for	ADP
eurjchem-885	150	62	itc	itc	PROPN
eurjchem-885	150	63	were	be	AUX
eurjchem-885	150	64	calculated	calculate	VERB
eurjchem-885	150	65	according	accord	VERB
eurjchem-885	150	66	to	to	ADP
eurjchem-885	150	67	ich	ich	PROPN
eurjchem-885	150	68	q2	q2	NOUN
eurjchem-885	150	69	(	(	PUNCT
eurjchem-885	150	70	r1	r1	PROPN
eurjchem-885	150	71	)	)	PUNCT
eurjchem-885	150	72	recommendation	recommendation	NOUN
eurjchem-885	150	73	[	[	X
eurjchem-885	150	74	25	25	NUM
eurjchem-885	150	75	]	]	PUNCT
eurjchem-885	150	76	.	.	PUNCT
eurjchem-885	151	1	lod	lod	PROPN
eurjchem-885	151	2	and	and	CCONJ
eurjchem-885	151	3	loq	loq	PROPN
eurjchem-885	151	4	were	be	AUX
eurjchem-885	151	5	found	find	VERB
eurjchem-885	151	6	5.4	5.4	NUM
eurjchem-885	151	7	and	and	CCONJ
eurjchem-885	151	8	16.4	16.4	NUM
eurjchem-885	151	9	µg	µg	NOUN
eurjchem-885	151	10	/	/	SYM
eurjchem-885	151	11	ml	ml	NOUN
eurjchem-885	151	12	,	,	PUNCT
eurjchem-885	151	13	respectively	respectively	ADV
eurjchem-885	151	14	.	.	PUNCT
eurjchem-885	152	1	figure	figure	NOUN
eurjchem-885	152	2	4	4	NUM
eurjchem-885	152	3	.	.	PUNCT
eurjchem-885	153	1	calibration	calibration	NOUN
eurjchem-885	153	2	curve	curve	NOUN
eurjchem-885	153	3	for	for	ADP
eurjchem-885	153	4	mlc	mlc	NOUN
eurjchem-885	153	5	determination	determination	NOUN
eurjchem-885	153	6	of	of	ADP
eurjchem-885	153	7	itc	itc	PROPN
eurjchem-885	153	8	.	.	PUNCT
eurjchem-885	154	1	3.4.2	3.4.2	NUM
eurjchem-885	154	2	.	.	PUNCT
eurjchem-885	154	3	accuracy	accuracy	NOUN
eurjchem-885	154	4	to	to	PART
eurjchem-885	154	5	prove	prove	VERB
eurjchem-885	154	6	the	the	DET
eurjchem-885	154	7	accuracy	accuracy	NOUN
eurjchem-885	154	8	of	of	ADP
eurjchem-885	154	9	the	the	DET
eurjchem-885	154	10	proposed	propose	VERB
eurjchem-885	154	11	method	method	NOUN
eurjchem-885	154	12	,	,	PUNCT
eurjchem-885	154	13	the	the	DET
eurjchem-885	154	14	results	result	NOUN
eurjchem-885	154	15	of	of	ADP
eurjchem-885	154	16	the	the	DET
eurjchem-885	154	17	assay	assay	NOUN
eurjchem-885	154	18	of	of	ADP
eurjchem-885	154	19	itc	itc	PROPN
eurjchem-885	154	20	in	in	ADP
eurjchem-885	154	21	pure	pure	ADJ
eurjchem-885	154	22	form	form	NOUN
eurjchem-885	154	23	by	by	ADP
eurjchem-885	154	24	the	the	DET
eurjchem-885	154	25	proposed	propose	VERB
eurjchem-885	154	26	mlc	mlc	NOUN
eurjchem-885	154	27	method	method	NOUN
eurjchem-885	154	28	were	be	AUX
eurjchem-885	154	29	compared	compare	VERB
eurjchem-885	154	30	with	with	ADP
eurjchem-885	154	31	those	those	PRON
eurjchem-885	154	32	obtained	obtain	VERB
eurjchem-885	154	33	using	use	VERB
eurjchem-885	154	34	a	a	DET
eurjchem-885	154	35	reference	reference	NOUN
eurjchem-885	154	36	hplc	hplc	NOUN
eurjchem-885	154	37	method	method	NOUN
eurjchem-885	154	38	[	[	X
eurjchem-885	154	39	2	2	NUM
eurjchem-885	154	40	]	]	PUNCT
eurjchem-885	154	41	.	.	PUNCT
eurjchem-885	155	1	statistical	statistical	ADJ
eurjchem-885	155	2	comparison	comparison	NOUN
eurjchem-885	155	3	using	use	VERB
eurjchem-885	155	4	t‐test	t‐test	PUNCT
eurjchem-885	155	5	and	and	CCONJ
eurjchem-885	155	6	f‐test	f‐test	ADV
eurjchem-885	155	7	revealed	reveal	VERB
eurjchem-885	155	8	no	no	DET
eurjchem-885	155	9	significant	significant	ADJ
eurjchem-885	155	10	differences	difference	NOUN
eurjchem-885	155	11	between	between	ADP
eurjchem-885	155	12	the	the	DET
eurjchem-885	155	13	performance	performance	NOUN
eurjchem-885	155	14	of	of	ADP
eurjchem-885	155	15	the	the	DET
eurjchem-885	155	16	two	two	NUM
eurjchem-885	155	17	methods	method	NOUN
eurjchem-885	155	18	regarding	regard	VERB
eurjchem-885	155	19	the	the	DET
eurjchem-885	155	20	accuracy	accuracy	NOUN
eurjchem-885	155	21	and	and	CCONJ
eurjchem-885	155	22	precision	precision	NOUN
eurjchem-885	155	23	,	,	PUNCT
eurjchem-885	155	24	respectively	respectively	ADV
eurjchem-885	155	25	as	as	SCONJ
eurjchem-885	155	26	illustrated	illustrate	VERB
eurjchem-885	155	27	in	in	ADP
eurjchem-885	155	28	table	table	NOUN
eurjchem-885	155	29	2	2	NUM
eurjchem-885	155	30	.	.	PUNCT
eurjchem-885	156	1	3.4.3	3.4.3	NUM
eurjchem-885	156	2	.	.	PUNCT
eurjchem-885	156	3	precision	precision	PROPN
eurjchem-885	156	4	intra‐day	intra‐day	PROPN
eurjchem-885	156	5	precision	precision	NOUN
eurjchem-885	156	6	was	be	AUX
eurjchem-885	156	7	achieved	achieve	VERB
eurjchem-885	156	8	by	by	ADP
eurjchem-885	156	9	six	six	NUM
eurjchem-885	156	10	replicate	replicate	ADJ
eurjchem-885	156	11	determination	determination	NOUN
eurjchem-885	156	12	of	of	ADP
eurjchem-885	156	13	200	200	NUM
eurjchem-885	156	14	µg	µg	NOUN
eurjchem-885	156	15	/	/	SYM
eurjchem-885	156	16	ml	ml	NOUN
eurjchem-885	156	17	in	in	ADP
eurjchem-885	156	18	the	the	DET
eurjchem-885	156	19	three	three	NUM
eurjchem-885	156	20	dosage	dosage	NOUN
eurjchem-885	156	21	forms	form	NOUN
eurjchem-885	156	22	on	on	ADP
eurjchem-885	156	23	three	three	NUM
eurjchem-885	156	24	successive	successive	ADJ
eurjchem-885	156	25	times	time	NOUN
eurjchem-885	156	26	in	in	ADP
eurjchem-885	156	27	the	the	DET
eurjchem-885	156	28	same	same	ADJ
eurjchem-885	156	29	day	day	NOUN
eurjchem-885	156	30	.	.	PUNCT
eurjchem-885	157	1	inter‐day	inter‐day	PROPN
eurjchem-885	157	2	precision	precision	NOUN
eurjchem-885	157	3	was	be	AUX
eurjchem-885	157	4	performed	perform	VERB
eurjchem-885	157	5	as	as	ADP
eurjchem-885	157	6	intra‐day	intra‐day	NOUN
eurjchem-885	157	7	precision	precision	NOUN
eurjchem-885	157	8	but	but	CCONJ
eurjchem-885	157	9	on	on	ADP
eurjchem-885	157	10	three	three	NUM
eurjchem-885	157	11	successive	successive	ADJ
eurjchem-885	157	12	days	day	NOUN
eurjchem-885	157	13	.	.	PUNCT
eurjchem-885	158	1	small	small	ADJ
eurjchem-885	158	2	values	value	NOUN
eurjchem-885	158	3	of	of	ADP
eurjchem-885	158	4	%	%	NOUN
eurjchem-885	158	5	error	error	NOUN
eurjchem-885	158	6	and	and	CCONJ
eurjchem-885	158	7	%	%	NOUN
eurjchem-885	158	8	rsd	rsd	PROPN
eurjchem-885	158	9	revealed	reveal	VERB
eurjchem-885	158	10	the	the	DET
eurjchem-885	158	11	precision	precision	NOUN
eurjchem-885	158	12	of	of	ADP
eurjchem-885	158	13	the	the	DET
eurjchem-885	158	14	proposed	propose	VERB
eurjchem-885	158	15	method	method	NOUN
eurjchem-885	158	16	.	.	PUNCT
eurjchem-885	159	1	the	the	DET
eurjchem-885	159	2	results	result	NOUN
eurjchem-885	159	3	are	be	AUX
eurjchem-885	159	4	illustrated	illustrate	VERB
eurjchem-885	159	5	in	in	ADP
eurjchem-885	159	6	table	table	NOUN
eurjchem-885	159	7	3	3	NUM
eurjchem-885	159	8	.	.	X
eurjchem-885	160	1	3.4.4	3.4.4	NUM
eurjchem-885	160	2	.	.	PUNCT
eurjchem-885	160	3	selectivity	selectivity	VERB
eurjchem-885	160	4	the	the	DET
eurjchem-885	160	5	selectivity	selectivity	NOUN
eurjchem-885	160	6	of	of	ADP
eurjchem-885	160	7	the	the	DET
eurjchem-885	160	8	proposed	propose	VERB
eurjchem-885	160	9	mlc	mlc	NOUN
eurjchem-885	160	10	method	method	NOUN
eurjchem-885	160	11	was	be	AUX
eurjchem-885	160	12	established	establish	VERB
eurjchem-885	160	13	by	by	ADP
eurjchem-885	160	14	its	its	PRON
eurjchem-885	160	15	ability	ability	NOUN
eurjchem-885	160	16	to	to	PART
eurjchem-885	160	17	determine	determine	VERB
eurjchem-885	160	18	itc	itc	PROPN
eurjchem-885	160	19	in	in	ADP
eurjchem-885	160	20	commercial	commercial	ADJ
eurjchem-885	160	21	capsules	capsule	NOUN
eurjchem-885	160	22	without	without	ADP
eurjchem-885	160	23	interference	interference	NOUN
eurjchem-885	160	24	from	from	ADP
eurjchem-885	160	25	common	common	ADJ
eurjchem-885	160	26	tablet	tablet	NOUN
eurjchem-885	160	27	additives	additive	NOUN
eurjchem-885	160	28	.	.	PUNCT
eurjchem-885	161	1	the	the	DET
eurjchem-885	161	2	common	common	ADJ
eurjchem-885	161	3	capsule	capsule	NOUN
eurjchem-885	161	4	additives	additive	NOUN
eurjchem-885	161	5	did	do	AUX
eurjchem-885	161	6	not	not	PART
eurjchem-885	161	7	show	show	VERB
eurjchem-885	161	8	any	any	DET
eurjchem-885	161	9	interfering	interfere	VERB
eurjchem-885	161	10	peaks	peak	NOUN
eurjchem-885	161	11	at	at	ADP
eurjchem-885	161	12	the	the	DET
eurjchem-885	161	13	retention	retention	NOUN
eurjchem-885	161	14	times	time	NOUN
eurjchem-885	161	15	of	of	ADP
eurjchem-885	161	16	the	the	DET
eurjchem-885	161	17	drug	drug	NOUN
eurjchem-885	161	18	,	,	PUNCT
eurjchem-885	161	19	which	which	PRON
eurjchem-885	161	20	proved	prove	VERB
eurjchem-885	161	21	the	the	DET
eurjchem-885	161	22	homogeneity	homogeneity	NOUN
eurjchem-885	161	23	and	and	CCONJ
eurjchem-885	161	24	purity	purity	NOUN
eurjchem-885	161	25	of	of	ADP
eurjchem-885	161	26	the	the	DET
eurjchem-885	161	27	peak	peak	NOUN
eurjchem-885	161	28	.	.	PUNCT
eurjchem-885	162	1	furthermore	furthermore	ADV
eurjchem-885	162	2	,	,	PUNCT
eurjchem-885	162	3	to	to	PART
eurjchem-885	162	4	evaluate	evaluate	VERB
eurjchem-885	162	5	the	the	DET
eurjchem-885	162	6	specificity	specificity	NOUN
eurjchem-885	162	7	of	of	ADP
eurjchem-885	162	8	the	the	DET
eurjchem-885	162	9	method	method	NOUN
eurjchem-885	162	10	to	to	PART
eurjchem-885	162	11	determine	determine	VERB
eurjchem-885	162	12	itc	itc	PROPN
eurjchem-885	162	13	in	in	ADP
eurjchem-885	162	14	human	human	ADJ
eurjchem-885	162	15	plasma	plasma	NOUN
eurjchem-885	162	16	,	,	PUNCT
eurjchem-885	162	17	blank	blank	ADJ
eurjchem-885	162	18	plasma	plasma	NOUN
eurjchem-885	162	19	was	be	AUX
eurjchem-885	162	20	diluted	dilute	VERB
eurjchem-885	162	21	with	with	ADP
eurjchem-885	162	22	the	the	DET
eurjchem-885	162	23	micellar	micellar	ADJ
eurjchem-885	162	24	mobile	mobile	ADJ
eurjchem-885	162	25	phase	phase	NOUN
eurjchem-885	162	26	and	and	CCONJ
eurjchem-885	162	27	injected	inject	VERB
eurjchem-885	162	28	under	under	ADP
eurjchem-885	162	29	the	the	DET
eurjchem-885	162	30	recommended	recommend	VERB
eurjchem-885	162	31	chromatographic	chromatographic	ADJ
eurjchem-885	162	32	conditions	condition	NOUN
eurjchem-885	162	33	.	.	PUNCT
eurjchem-885	163	1	no	no	DET
eurjchem-885	163	2	endogenous	endogenous	ADJ
eurjchem-885	163	3	interference	interference	NOUN
eurjchem-885	163	4	was	be	AUX
eurjchem-885	163	5	observed	observe	VERB
eurjchem-885	163	6	at	at	ADP
eurjchem-885	163	7	the	the	DET
eurjchem-885	163	8	retention	retention	NOUN
eurjchem-885	163	9	time	time	NOUN
eurjchem-885	163	10	of	of	ADP
eurjchem-885	163	11	itc	itc	PROPN
eurjchem-885	163	12	,	,	PUNCT
eurjchem-885	163	13	proving	prove	VERB
eurjchem-885	163	14	the	the	DET
eurjchem-885	163	15	specificity	specificity	NOUN
eurjchem-885	163	16	of	of	ADP
eurjchem-885	163	17	the	the	DET
eurjchem-885	163	18	method	method	NOUN
eurjchem-885	163	19	.	.	PUNCT
eurjchem-885	164	1	rizk	rizk	PROPN
eurjchem-885	164	2	et	et	PROPN
eurjchem-885	164	3	al	al	PROPN
eurjchem-885	164	4	.	.	PUNCT
eurjchem-885	164	5	/	/	SYM
eurjchem-885	164	6	european	european	PROPN
eurjchem-885	164	7	journal	journal	PROPN
eurjchem-885	164	8	of	of	ADP
eurjchem-885	164	9	chemistry	chemistry	NOUN
eurjchem-885	164	10	5	5	NUM
eurjchem-885	164	11	(	(	PUNCT
eurjchem-885	164	12	1	1	NUM
eurjchem-885	164	13	)	)	PUNCT
eurjchem-885	164	14	(	(	PUNCT
eurjchem-885	164	15	2014	2014	NUM
eurjchem-885	164	16	)	)	PUNCT
eurjchem-885	164	17	11‐17	11‐17	NOUN
eurjchem-885	164	18	15	15	NUM
eurjchem-885	164	19	table	table	NOUN
eurjchem-885	164	20	3	3	NUM
eurjchem-885	164	21	.	.	PUNCT
eurjchem-885	164	22	precision	precision	NOUN
eurjchem-885	164	23	data	datum	NOUN
eurjchem-885	164	24	of	of	ADP
eurjchem-885	164	25	the	the	DET
eurjchem-885	164	26	proposed	propose	VERB
eurjchem-885	164	27	method	method	NOUN
eurjchem-885	164	28	for	for	ADP
eurjchem-885	164	29	the	the	DET
eurjchem-885	164	30	determination	determination	NOUN
eurjchem-885	164	31	of	of	ADP
eurjchem-885	164	32	itc	itc	PROPN
eurjchem-885	164	33	in	in	ADP
eurjchem-885	164	34	dosage	dosage	NOUN
eurjchem-885	164	35	forms	form	NOUN
eurjchem-885	164	36	.	.	PUNCT
eurjchem-885	165	1	parameters	parameter	NOUN
eurjchem-885	165	2	%	%	INTJ
eurjchem-885	165	3	found±sd	found±sd	NOUN
eurjchem-885	166	1	%	%	NOUN
eurjchem-885	166	2	rsd	rsd	NOUN
eurjchem-885	166	3	%	%	NOUN
eurjchem-885	166	4	error	error	NOUN
eurjchem-885	166	5	intra‐day	intra‐day	NOUN
eurjchem-885	166	6	precision	precision	NOUN
eurjchem-885	166	7	itrapex	itrapex	PROPN
eurjchem-885	166	8	cap	cap	PROPN
eurjchem-885	166	9	102.8±1.4	102.8±1.4	NUM
eurjchem-885	166	10	1.36	1.36	NUM
eurjchem-885	166	11	0.3	0.3	NUM
eurjchem-885	166	12	itracon	itracon	NOUN
eurjchem-885	166	13	cap	cap	NOUN
eurjchem-885	166	14	99.2±1.2	99.2±1.2	NUM
eurjchem-885	166	15	1.21	1.21	NUM
eurjchem-885	166	16	0.3	0.3	NUM
eurjchem-885	166	17	itranox	itranox	NOUN
eurjchem-885	166	18	cap	cap	NOUN
eurjchem-885	166	19	103.5±0.5	103.5±0.5	NUM
eurjchem-885	166	20	0.51	0.51	NUM
eurjchem-885	166	21	0.1	0.1	NUM
eurjchem-885	166	22	inter‐day	inter‐day	NOUN
eurjchem-885	166	23	precision	precision	NOUN
eurjchem-885	166	24	itrapex	itrapex	PROPN
eurjchem-885	166	25	cap	cap	NOUN
eurjchem-885	166	26	103.4±1.2	103.4±1.2	PROPN
eurjchem-885	166	27	1.16	1.16	NUM
eurjchem-885	166	28	0.3	0.3	NUM
eurjchem-885	166	29	itracon	itracon	NOUN
eurjchem-885	166	30	cap	cap	NOUN
eurjchem-885	166	31	98.2±1.2	98.2±1.2	NUM
eurjchem-885	166	32	1.22	1.22	NUM
eurjchem-885	166	33	0.3	0.3	NUM
eurjchem-885	166	34	itranox	itranox	NOUN
eurjchem-885	166	35	cap	cap	NOUN
eurjchem-885	166	36	102.2±0.8	102.2±0.8	NUM
eurjchem-885	166	37	0.78	0.78	NUM
eurjchem-885	166	38	0.2	0.2	NUM
eurjchem-885	166	39	table	table	NOUN
eurjchem-885	166	40	4	4	NUM
eurjchem-885	166	41	.	.	PUNCT
eurjchem-885	167	1	sst	sst	NOUN
eurjchem-885	167	2	parameters	parameter	NOUN
eurjchem-885	167	3	for	for	ADP
eurjchem-885	167	4	the	the	DET
eurjchem-885	167	5	developed	develop	VERB
eurjchem-885	167	6	200	200	NUM
eurjchem-885	167	7	µg	µg	ADJ
eurjchem-885	167	8	/	/	SYM
eurjchem-885	167	9	ml	ml	NOUN
eurjchem-885	167	10	mlc	mlc	PROPN
eurjchem-885	167	11	method	method	PROPN
eurjchem-885	167	12	.	.	PUNCT
eurjchem-885	168	1	parameters	parameter	NOUN
eurjchem-885	168	2	itc	itc	VERB
eurjchem-885	168	3	no	no	PRON
eurjchem-885	168	4	of	of	ADP
eurjchem-885	168	5	theoretical	theoretical	ADJ
eurjchem-885	168	6	plates	plate	NOUN
eurjchem-885	168	7	,	,	PUNCT
eurjchem-885	168	8	n	n	PRON
eurjchem-885	168	9	505	505	NUM
eurjchem-885	168	10	capacity	capacity	NOUN
eurjchem-885	168	11	factor	factor	NOUN
eurjchem-885	168	12	,	,	PUNCT
eurjchem-885	168	13	k	k	NOUN
eurjchem-885	168	14	’	'	PUNCT
eurjchem-885	168	15	2.02	2.02	NUM
eurjchem-885	168	16	selectivity	selectivity	NOUN
eurjchem-885	168	17	factor	factor	NOUN
eurjchem-885	168	18	,	,	PUNCT
eurjchem-885	168	19	α	α	NOUN
eurjchem-885	168	20	2.02	2.02	NUM
eurjchem-885	168	21	resolution	resolution	NOUN
eurjchem-885	168	22	factor	factor	NOUN
eurjchem-885	168	23	,	,	PUNCT
eurjchem-885	168	24	rs	rs	PROPN
eurjchem-885	168	25	4.68	4.68	NUM
eurjchem-885	168	26	forced	force	VERB
eurjchem-885	168	27	degradation	degradation	NOUN
eurjchem-885	168	28	studies	study	NOUN
eurjchem-885	168	29	were	be	AUX
eurjchem-885	168	30	also	also	ADV
eurjchem-885	168	31	performed	perform	VERB
eurjchem-885	168	32	to	to	PART
eurjchem-885	168	33	evaluate	evaluate	VERB
eurjchem-885	168	34	the	the	DET
eurjchem-885	168	35	validity	validity	NOUN
eurjchem-885	168	36	of	of	ADP
eurjchem-885	168	37	the	the	DET
eurjchem-885	168	38	method	method	NOUN
eurjchem-885	168	39	.	.	PUNCT
eurjchem-885	169	1	the	the	DET
eurjchem-885	169	2	results	result	NOUN
eurjchem-885	169	3	obtained	obtain	VERB
eurjchem-885	169	4	indicated	indicate	VERB
eurjchem-885	169	5	that	that	SCONJ
eurjchem-885	169	6	the	the	DET
eurjchem-885	169	7	proposed	propose	VERB
eurjchem-885	169	8	mlc	mlc	NOUN
eurjchem-885	169	9	method	method	NOUN
eurjchem-885	169	10	is	be	AUX
eurjchem-885	169	11	selective	selective	ADJ
eurjchem-885	169	12	and	and	CCONJ
eurjchem-885	169	13	able	able	ADJ
eurjchem-885	169	14	to	to	PART
eurjchem-885	169	15	determine	determine	VERB
eurjchem-885	169	16	itc	itc	PROPN
eurjchem-885	169	17	in	in	ADP
eurjchem-885	169	18	presence	presence	NOUN
eurjchem-885	169	19	of	of	ADP
eurjchem-885	169	20	its	its	PRON
eurjchem-885	169	21	degradation	degradation	NOUN
eurjchem-885	169	22	products	product	NOUN
eurjchem-885	169	23	.	.	PUNCT
eurjchem-885	170	1	3.4.5	3.4.5	X
eurjchem-885	170	2	.	.	PUNCT
eurjchem-885	170	3	sample	sample	NOUN
eurjchem-885	170	4	solution	solution	NOUN
eurjchem-885	170	5	stability	stability	NOUN
eurjchem-885	170	6	and	and	CCONJ
eurjchem-885	170	7	mobile	mobile	ADJ
eurjchem-885	170	8	phase	phase	NOUN
eurjchem-885	170	9	stability	stability	NOUN
eurjchem-885	170	10	evaluation	evaluation	NOUN
eurjchem-885	170	11	of	of	ADP
eurjchem-885	170	12	the	the	DET
eurjchem-885	170	13	stability	stability	NOUN
eurjchem-885	170	14	of	of	ADP
eurjchem-885	170	15	itc	itc	PROPN
eurjchem-885	170	16	solution	solution	NOUN
eurjchem-885	170	17	was	be	AUX
eurjchem-885	170	18	achieved	achieve	VERB
eurjchem-885	170	19	by	by	ADP
eurjchem-885	170	20	quantification	quantification	NOUN
eurjchem-885	170	21	of	of	ADP
eurjchem-885	170	22	itc	itc	PROPN
eurjchem-885	170	23	on	on	ADP
eurjchem-885	170	24	three	three	NUM
eurjchem-885	170	25	successive	successive	ADJ
eurjchem-885	170	26	days	day	NOUN
eurjchem-885	170	27	and	and	CCONJ
eurjchem-885	170	28	comparison	comparison	NOUN
eurjchem-885	170	29	to	to	ADP
eurjchem-885	170	30	freshly	freshly	ADV
eurjchem-885	170	31	prepared	prepare	VERB
eurjchem-885	170	32	solution	solution	NOUN
eurjchem-885	170	33	.	.	PUNCT
eurjchem-885	171	1	similarly	similarly	ADV
eurjchem-885	171	2	,	,	PUNCT
eurjchem-885	171	3	the	the	DET
eurjchem-885	171	4	stability	stability	NOUN
eurjchem-885	171	5	of	of	ADP
eurjchem-885	171	6	the	the	DET
eurjchem-885	171	7	mobile	mobile	ADJ
eurjchem-885	171	8	phase	phase	NOUN
eurjchem-885	171	9	was	be	AUX
eurjchem-885	171	10	checked	check	VERB
eurjchem-885	171	11	.	.	PUNCT
eurjchem-885	172	1	no	no	DET
eurjchem-885	172	2	significant	significant	ADJ
eurjchem-885	172	3	changes	change	NOUN
eurjchem-885	172	4	were	be	AUX
eurjchem-885	172	5	observed	observe	VERB
eurjchem-885	172	6	in	in	ADP
eurjchem-885	172	7	standard	standard	ADJ
eurjchem-885	172	8	solution	solution	NOUN
eurjchem-885	172	9	or	or	CCONJ
eurjchem-885	172	10	mobile	mobile	ADJ
eurjchem-885	172	11	phase	phase	NOUN
eurjchem-885	172	12	responses	response	NOUN
eurjchem-885	172	13	,	,	PUNCT
eurjchem-885	172	14	proved	prove	VERB
eurjchem-885	172	15	that	that	SCONJ
eurjchem-885	172	16	they	they	PRON
eurjchem-885	172	17	were	be	AUX
eurjchem-885	172	18	stable	stable	ADJ
eurjchem-885	172	19	up	up	ADP
eurjchem-885	172	20	to	to	PART
eurjchem-885	172	21	3	3	NUM
eurjchem-885	172	22	days	day	NOUN
eurjchem-885	172	23	.	.	PUNCT
eurjchem-885	173	1	3.4.6	3.4.6	X
eurjchem-885	173	2	.	.	PUNCT
eurjchem-885	173	3	system	system	NOUN
eurjchem-885	173	4	suitability	suitability	NOUN
eurjchem-885	173	5	test	test	NOUN
eurjchem-885	173	6	(	(	PUNCT
eurjchem-885	173	7	sst	sst	NOUN
eurjchem-885	173	8	)	)	PUNCT
eurjchem-885	173	9	evaluation	evaluation	NOUN
eurjchem-885	173	10	of	of	ADP
eurjchem-885	173	11	sst	sst	NOUN
eurjchem-885	173	12	parameters	parameter	NOUN
eurjchem-885	173	13	was	be	AUX
eurjchem-885	173	14	performed	perform	VERB
eurjchem-885	173	15	during	during	ADP
eurjchem-885	173	16	the	the	DET
eurjchem-885	173	17	development	development	NOUN
eurjchem-885	173	18	and	and	CCONJ
eurjchem-885	173	19	optimization	optimization	NOUN
eurjchem-885	173	20	of	of	ADP
eurjchem-885	173	21	the	the	DET
eurjchem-885	173	22	method	method	NOUN
eurjchem-885	173	23	.	.	PUNCT
eurjchem-885	174	1	moreover	moreover	ADV
eurjchem-885	174	2	,	,	PUNCT
eurjchem-885	174	3	to	to	PART
eurjchem-885	174	4	ascertain	ascertain	VERB
eurjchem-885	174	5	the	the	DET
eurjchem-885	174	6	effectiveness	effectiveness	NOUN
eurjchem-885	174	7	of	of	ADP
eurjchem-885	174	8	the	the	DET
eurjchem-885	174	9	final	final	ADJ
eurjchem-885	174	10	operating	operating	NOUN
eurjchem-885	174	11	system	system	NOUN
eurjchem-885	174	12	,	,	PUNCT
eurjchem-885	174	13	it	it	PRON
eurjchem-885	174	14	was	be	AUX
eurjchem-885	174	15	subjected	subject	VERB
eurjchem-885	174	16	to	to	ADP
eurjchem-885	174	17	suitability	suitability	NOUN
eurjchem-885	174	18	testing	testing	NOUN
eurjchem-885	174	19	.	.	PUNCT
eurjchem-885	175	1	the	the	DET
eurjchem-885	175	2	test	test	NOUN
eurjchem-885	175	3	was	be	AUX
eurjchem-885	175	4	performed	perform	VERB
eurjchem-885	175	5	by	by	ADP
eurjchem-885	175	6	injecting	inject	VERB
eurjchem-885	175	7	the	the	DET
eurjchem-885	175	8	standard	standard	ADJ
eurjchem-885	175	9	sample	sample	NOUN
eurjchem-885	175	10	in	in	ADP
eurjchem-885	175	11	triplicate	triplicate	NOUN
eurjchem-885	175	12	and	and	CCONJ
eurjchem-885	175	13	the	the	DET
eurjchem-885	175	14	sst	sst	NOUN
eurjchem-885	175	15	parameters	parameter	NOUN
eurjchem-885	175	16	were	be	AUX
eurjchem-885	175	17	calculated	calculate	VERB
eurjchem-885	175	18	as	as	SCONJ
eurjchem-885	175	19	reported	report	VERB
eurjchem-885	175	20	by	by	ADP
eurjchem-885	175	21	usp	usp	PROPN
eurjchem-885	175	22	[	[	X
eurjchem-885	175	23	27	27	NUM
eurjchem-885	175	24	]	]	PUNCT
eurjchem-885	175	25	which	which	PRON
eurjchem-885	175	26	include	include	VERB
eurjchem-885	175	27	capacity	capacity	NOUN
eurjchem-885	175	28	factor	factor	NOUN
eurjchem-885	175	29	(	(	PUNCT
eurjchem-885	175	30	k	k	NOUN
eurjchem-885	175	31	’	'	PUNCT
eurjchem-885	175	32	)	)	PUNCT
eurjchem-885	175	33	,	,	PUNCT
eurjchem-885	175	34	selectivity	selectivity	NOUN
eurjchem-885	175	35	factor	factor	NOUN
eurjchem-885	175	36	(	(	PUNCT
eurjchem-885	175	37	α	α	NOUN
eurjchem-885	175	38	)	)	PUNCT
eurjchem-885	175	39	,	,	PUNCT
eurjchem-885	175	40	resolution	resolution	NOUN
eurjchem-885	175	41	factor	factor	NOUN
eurjchem-885	175	42	(	(	PUNCT
eurjchem-885	175	43	rs	rs	NOUN
eurjchem-885	175	44	)	)	PUNCT
eurjchem-885	175	45	,	,	PUNCT
eurjchem-885	175	46	column	column	NOUN
eurjchem-885	175	47	efficiency	efficiency	NOUN
eurjchem-885	175	48	(	(	PUNCT
eurjchem-885	175	49	number	number	NOUN
eurjchem-885	175	50	of	of	ADP
eurjchem-885	175	51	theoretical	theoretical	ADJ
eurjchem-885	175	52	plates	plate	NOUN
eurjchem-885	175	53	,	,	PUNCT
eurjchem-885	175	54	n	n	CCONJ
eurjchem-885	175	55	)	)	PUNCT
eurjchem-885	175	56	.	.	PUNCT
eurjchem-885	176	1	the	the	DET
eurjchem-885	176	2	final	final	ADJ
eurjchem-885	176	3	sst	sst	NOUN
eurjchem-885	176	4	parameters	parameter	NOUN
eurjchem-885	176	5	under	under	ADP
eurjchem-885	176	6	the	the	DET
eurjchem-885	176	7	optimum	optimum	ADJ
eurjchem-885	176	8	chromatographic	chromatographic	ADJ
eurjchem-885	176	9	conditions	condition	NOUN
eurjchem-885	176	10	are	be	AUX
eurjchem-885	176	11	summarized	summarize	VERB
eurjchem-885	176	12	in	in	ADP
eurjchem-885	176	13	table	table	NOUN
eurjchem-885	176	14	4	4	NUM
eurjchem-885	176	15	.	.	PUNCT
eurjchem-885	176	16	3.4.7	3.4.7	NUM
eurjchem-885	176	17	.	.	PUNCT
eurjchem-885	177	1	robustness	robustness	NOUN
eurjchem-885	177	2	to	to	PART
eurjchem-885	177	3	assess	assess	VERB
eurjchem-885	177	4	the	the	DET
eurjchem-885	177	5	robustness	robustness	NOUN
eurjchem-885	177	6	of	of	ADP
eurjchem-885	177	7	the	the	DET
eurjchem-885	177	8	proposed	propose	VERB
eurjchem-885	177	9	mlc	mlc	NOUN
eurjchem-885	177	10	method	method	NOUN
eurjchem-885	177	11	,	,	PUNCT
eurjchem-885	177	12	the	the	DET
eurjchem-885	177	13	chromatographic	chromatographic	ADJ
eurjchem-885	177	14	conditions	condition	NOUN
eurjchem-885	177	15	were	be	AUX
eurjchem-885	177	16	deliberately	deliberately	ADV
eurjchem-885	177	17	altered	alter	VERB
eurjchem-885	177	18	such	such	ADJ
eurjchem-885	177	19	as	as	ADP
eurjchem-885	177	20	concentration	concentration	NOUN
eurjchem-885	177	21	of	of	ADP
eurjchem-885	177	22	1‐propanol	1‐propanol	NUM
eurjchem-885	177	23	(	(	PUNCT
eurjchem-885	177	24	20±0.5	20±0.5	NUM
eurjchem-885	177	25	%	%	NOUN
eurjchem-885	177	26	,	,	PUNCT
eurjchem-885	177	27	v	v	NOUN
eurjchem-885	177	28	:	:	PUNCT
eurjchem-885	177	29	v	v	NOUN
eurjchem-885	177	30	)	)	PUNCT
eurjchem-885	177	31	,	,	PUNCT
eurjchem-885	177	32	strength	strength	NOUN
eurjchem-885	177	33	of	of	ADP
eurjchem-885	177	34	ortho‐	ortho‐	ADJ
eurjchem-885	177	35	phosphoric	phosphoric	NOUN
eurjchem-885	177	36	acid	acid	NOUN
eurjchem-885	177	37	(	(	PUNCT
eurjchem-885	177	38	0.02±0.005	0.02±0.005	PROPN
eurjchem-885	177	39	m	m	PROPN
eurjchem-885	177	40	)	)	PUNCT
eurjchem-885	177	41	,	,	PUNCT
eurjchem-885	177	42	concentration	concentration	NOUN
eurjchem-885	177	43	of	of	ADP
eurjchem-885	177	44	tea	tea	NOUN
eurjchem-885	177	45	(	(	PUNCT
eurjchem-885	177	46	0.3±0.01	0.3±0.01	ADJ
eurjchem-885	177	47	%	%	NOUN
eurjchem-885	177	48	)	)	PUNCT
eurjchem-885	177	49	.	.	PUNCT
eurjchem-885	178	1	the	the	DET
eurjchem-885	178	2	efficiency	efficiency	NOUN
eurjchem-885	178	3	of	of	ADP
eurjchem-885	178	4	the	the	DET
eurjchem-885	178	5	separation	separation	NOUN
eurjchem-885	178	6	of	of	ADP
eurjchem-885	178	7	itc	itc	PROPN
eurjchem-885	178	8	was	be	AUX
eurjchem-885	178	9	not	not	PART
eurjchem-885	178	10	affected	affect	VERB
eurjchem-885	178	11	indicating	indicate	VERB
eurjchem-885	178	12	the	the	DET
eurjchem-885	178	13	reliability	reliability	NOUN
eurjchem-885	178	14	of	of	ADP
eurjchem-885	178	15	the	the	DET
eurjchem-885	178	16	proposed	propose	VERB
eurjchem-885	178	17	method	method	NOUN
eurjchem-885	178	18	.	.	PUNCT
eurjchem-885	179	1	therefore	therefore	ADV
eurjchem-885	179	2	,	,	PUNCT
eurjchem-885	179	3	the	the	DET
eurjchem-885	179	4	method	method	NOUN
eurjchem-885	179	5	is	be	AUX
eurjchem-885	179	6	robust	robust	ADJ
eurjchem-885	179	7	to	to	ADP
eurjchem-885	179	8	the	the	DET
eurjchem-885	179	9	small	small	ADJ
eurjchem-885	179	10	changes	change	NOUN
eurjchem-885	179	11	in	in	ADP
eurjchem-885	179	12	experimental	experimental	ADJ
eurjchem-885	179	13	conditions	condition	NOUN
eurjchem-885	179	14	.	.	PUNCT
eurjchem-885	180	1	3.5	3.5	NUM
eurjchem-885	180	2	.	.	PUNCT
eurjchem-885	180	3	applications	application	NOUN
eurjchem-885	180	4	3.5.1	3.5.1	NUM
eurjchem-885	180	5	.	.	PUNCT
eurjchem-885	181	1	application	application	NOUN
eurjchem-885	181	2	of	of	ADP
eurjchem-885	181	3	the	the	DET
eurjchem-885	181	4	proposed	propose	VERB
eurjchem-885	181	5	method	method	NOUN
eurjchem-885	181	6	to	to	ADP
eurjchem-885	181	7	the	the	DET
eurjchem-885	181	8	determination	determination	NOUN
eurjchem-885	181	9	of	of	ADP
eurjchem-885	181	10	itc	itc	PROPN
eurjchem-885	181	11	in	in	ADP
eurjchem-885	181	12	capsules	capsule	NOUN
eurjchem-885	181	13	the	the	DET
eurjchem-885	181	14	developed	develop	VERB
eurjchem-885	181	15	mlc	mlc	NOUN
eurjchem-885	181	16	method	method	NOUN
eurjchem-885	181	17	was	be	AUX
eurjchem-885	181	18	applied	apply	VERB
eurjchem-885	181	19	successfully	successfully	ADV
eurjchem-885	181	20	for	for	ADP
eurjchem-885	181	21	the	the	DET
eurjchem-885	181	22	assay	assay	NOUN
eurjchem-885	181	23	of	of	ADP
eurjchem-885	181	24	itc	itc	PROPN
eurjchem-885	181	25	in	in	ADP
eurjchem-885	181	26	commercial	commercial	ADJ
eurjchem-885	181	27	capsules	capsule	NOUN
eurjchem-885	181	28	as	as	SCONJ
eurjchem-885	181	29	shown	show	VERB
eurjchem-885	181	30	in	in	ADP
eurjchem-885	181	31	figure	figure	NOUN
eurjchem-885	181	32	5	5	NUM
eurjchem-885	181	33	.	.	PUNCT
eurjchem-885	182	1	the	the	DET
eurjchem-885	182	2	results	result	NOUN
eurjchem-885	182	3	obtained	obtain	VERB
eurjchem-885	182	4	by	by	ADP
eurjchem-885	182	5	the	the	DET
eurjchem-885	182	6	developed	develop	VERB
eurjchem-885	182	7	mlc	mlc	NOUN
eurjchem-885	182	8	method	method	NOUN
eurjchem-885	182	9	were	be	AUX
eurjchem-885	182	10	statistically	statistically	ADV
eurjchem-885	182	11	compared	compare	VERB
eurjchem-885	182	12	with	with	ADP
eurjchem-885	182	13	those	those	PRON
eurjchem-885	182	14	of	of	ADP
eurjchem-885	182	15	the	the	DET
eurjchem-885	182	16	reference	reference	NOUN
eurjchem-885	182	17	hplc	hplc	NOUN
eurjchem-885	182	18	method	method	NOUN
eurjchem-885	182	19	[	[	X
eurjchem-885	182	20	2	2	NUM
eurjchem-885	182	21	]	]	PUNCT
eurjchem-885	182	22	using	use	VERB
eurjchem-885	182	23	the	the	DET
eurjchem-885	182	24	t‐test	t‐test	ADV
eurjchem-885	182	25	and	and	CCONJ
eurjchem-885	182	26	f‐test	f‐test	PUNCT
eurjchem-885	182	27	.	.	PUNCT
eurjchem-885	183	1	the	the	DET
eurjchem-885	183	2	results	result	NOUN
eurjchem-885	183	3	show	show	VERB
eurjchem-885	183	4	that	that	SCONJ
eurjchem-885	183	5	there	there	PRON
eurjchem-885	183	6	were	be	VERB
eurjchem-885	183	7	no	no	DET
eurjchem-885	183	8	significant	significant	ADJ
eurjchem-885	183	9	differences	difference	NOUN
eurjchem-885	183	10	between	between	ADP
eurjchem-885	183	11	the	the	DET
eurjchem-885	183	12	developed	develop	VERB
eurjchem-885	183	13	and	and	CCONJ
eurjchem-885	183	14	reference	reference	NOUN
eurjchem-885	183	15	methods	method	NOUN
eurjchem-885	183	16	regarding	regard	VERB
eurjchem-885	183	17	accuracy	accuracy	NOUN
eurjchem-885	183	18	and	and	CCONJ
eurjchem-885	183	19	precision	precision	NOUN
eurjchem-885	183	20	,	,	PUNCT
eurjchem-885	183	21	respectively	respectively	ADV
eurjchem-885	183	22	as	as	SCONJ
eurjchem-885	183	23	illustrated	illustrate	VERB
eurjchem-885	183	24	in	in	ADP
eurjchem-885	183	25	table	table	NOUN
eurjchem-885	183	26	5	5	NUM
eurjchem-885	183	27	.	.	PUNCT
eurjchem-885	184	1	the	the	DET
eurjchem-885	184	2	proposed	propose	VERB
eurjchem-885	184	3	method	method	NOUN
eurjchem-885	184	4	showed	show	VERB
eurjchem-885	184	5	satisfactory	satisfactory	ADJ
eurjchem-885	184	6	results	result	NOUN
eurjchem-885	184	7	for	for	ADP
eurjchem-885	184	8	determination	determination	NOUN
eurjchem-885	184	9	of	of	ADP
eurjchem-885	184	10	itc	itc	PROPN
eurjchem-885	184	11	in	in	ADP
eurjchem-885	184	12	spiked	spiked	ADJ
eurjchem-885	184	13	human	human	ADJ
eurjchem-885	184	14	plasma	plasma	NOUN
eurjchem-885	184	15	.	.	PUNCT
eurjchem-885	185	1	the	the	DET
eurjchem-885	185	2	assay	assay	NOUN
eurjchem-885	185	3	results	result	NOUN
eurjchem-885	185	4	using	use	VERB
eurjchem-885	185	5	the	the	DET
eurjchem-885	185	6	proposed	propose	VERB
eurjchem-885	185	7	method	method	NOUN
eurjchem-885	185	8	are	be	AUX
eurjchem-885	185	9	summarized	summarize	VERB
eurjchem-885	185	10	in	in	ADP
eurjchem-885	185	11	table	table	NOUN
eurjchem-885	185	12	6	6	NUM
eurjchem-885	185	13	.	.	PUNCT
eurjchem-885	186	1	3.5.2	3.5.2	NUM
eurjchem-885	186	2	.	.	PUNCT
eurjchem-885	186	3	application	application	NOUN
eurjchem-885	186	4	of	of	ADP
eurjchem-885	186	5	the	the	DET
eurjchem-885	186	6	proposed	propose	VERB
eurjchem-885	186	7	method	method	NOUN
eurjchem-885	186	8	to	to	ADP
eurjchem-885	186	9	the	the	DET
eurjchem-885	186	10	determination	determination	NOUN
eurjchem-885	186	11	of	of	ADP
eurjchem-885	186	12	itc	itc	PROPN
eurjchem-885	186	13	in	in	ADP
eurjchem-885	186	14	spiked	spiked	ADJ
eurjchem-885	186	15	human	human	ADJ
eurjchem-885	186	16	plasma	plasma	NOUN
eurjchem-885	186	17	mlc	mlc	NOUN
eurjchem-885	186	18	allows	allow	VERB
eurjchem-885	186	19	biological	biological	ADJ
eurjchem-885	186	20	samples	sample	NOUN
eurjchem-885	186	21	to	to	PART
eurjchem-885	186	22	be	be	AUX
eurjchem-885	186	23	analyzed	analyze	VERB
eurjchem-885	186	24	without	without	ADP
eurjchem-885	186	25	prior	prior	ADJ
eurjchem-885	186	26	tedious	tedious	ADJ
eurjchem-885	186	27	pre‐treatment	pre‐treatment	NOUN
eurjchem-885	186	28	for	for	ADP
eurjchem-885	186	29	plasma	plasma	NOUN
eurjchem-885	186	30	protein	protein	NOUN
eurjchem-885	186	31	precipitation	precipitation	NOUN
eurjchem-885	186	32	or	or	CCONJ
eurjchem-885	186	33	elimination	elimination	NOUN
eurjchem-885	186	34	of	of	ADP
eurjchem-885	186	35	other	other	ADJ
eurjchem-885	186	36	interfering	interfere	VERB
eurjchem-885	186	37	substances	substance	NOUN
eurjchem-885	186	38	,	,	PUNCT
eurjchem-885	186	39	thus	thus	ADV
eurjchem-885	186	40	considerably	considerably	ADV
eurjchem-885	186	41	reducing	reduce	VERB
eurjchem-885	186	42	the	the	DET
eurjchem-885	186	43	cost	cost	NOUN
eurjchem-885	186	44	and	and	CCONJ
eurjchem-885	186	45	analysis	analysis	NOUN
eurjchem-885	186	46	time	time	NOUN
eurjchem-885	186	47	.	.	PUNCT
eurjchem-885	187	1	the	the	DET
eurjchem-885	187	2	proposed	propose	VERB
eurjchem-885	187	3	mlc	mlc	NOUN
eurjchem-885	187	4	method	method	NOUN
eurjchem-885	187	5	was	be	AUX
eurjchem-885	187	6	successfully	successfully	ADV
eurjchem-885	187	7	applied	apply	VERB
eurjchem-885	187	8	to	to	ADP
eurjchem-885	187	9	the	the	DET
eurjchem-885	187	10	determination	determination	NOUN
eurjchem-885	187	11	of	of	ADP
eurjchem-885	187	12	itc	itc	PROPN
eurjchem-885	187	13	in	in	ADP
eurjchem-885	187	14	spiked	spiked	ADJ
eurjchem-885	187	15	human	human	ADJ
eurjchem-885	187	16	plasma	plasma	NOUN
eurjchem-885	187	17	.	.	PUNCT
eurjchem-885	188	1	figure	figure	NOUN
eurjchem-885	188	2	5	5	NUM
eurjchem-885	188	3	.	.	PUNCT
eurjchem-885	188	4	representative	representative	ADJ
eurjchem-885	188	5	chromatogram	chromatogram	NOUN
eurjchem-885	188	6	showing	show	VERB
eurjchem-885	188	7	200	200	NUM
eurjchem-885	188	8	µg	µg	NOUN
eurjchem-885	188	9	/	/	SYM
eurjchem-885	188	10	ml	ml	NOUN
eurjchem-885	188	11	itc	itc	PROPN
eurjchem-885	188	12	in	in	ADP
eurjchem-885	188	13	different	different	ADJ
eurjchem-885	188	14	capsule	capsule	NOUN
eurjchem-885	188	15	formulations	formulation	NOUN
eurjchem-885	188	16	,	,	PUNCT
eurjchem-885	188	17	where	where	SCONJ
eurjchem-885	188	18	:	:	PUNCT
eurjchem-885	188	19	(	(	PUNCT
eurjchem-885	188	20	a	a	X
eurjchem-885	188	21	)	)	PUNCT
eurjchem-885	188	22	itracon	itracon	PROPN
eurjchem-885	188	23	capsule	capsule	PROPN
eurjchem-885	188	24	(	(	PUNCT
eurjchem-885	188	25	b	b	NOUN
eurjchem-885	188	26	)	)	PUNCT
eurjchem-885	188	27	itrapex	itrapex	NOUN
eurjchem-885	188	28	capsule	capsule	NOUN
eurjchem-885	188	29	(	(	PUNCT
eurjchem-885	188	30	c	c	NOUN
eurjchem-885	188	31	)	)	PUNCT
eurjchem-885	188	32	itranox	itranox	NOUN
eurjchem-885	188	33	capsule	capsule	PROPN
eurjchem-885	188	34	.	.	PUNCT
eurjchem-885	189	1	table	table	NOUN
eurjchem-885	189	2	5	5	NUM
eurjchem-885	189	3	.	.	PUNCT
eurjchem-885	189	4	application	application	NOUN
eurjchem-885	189	5	of	of	ADP
eurjchem-885	189	6	the	the	DET
eurjchem-885	189	7	proposed	propose	VERB
eurjchem-885	189	8	and	and	CCONJ
eurjchem-885	189	9	reference	reference	NOUN
eurjchem-885	189	10	method	method	NOUN
eurjchem-885	189	11	for	for	ADP
eurjchem-885	189	12	the	the	DET
eurjchem-885	189	13	determination	determination	NOUN
eurjchem-885	189	14	of	of	ADP
eurjchem-885	189	15	itc	itc	PROPN
eurjchem-885	189	16	in	in	ADP
eurjchem-885	189	17	capsules	capsule	NOUN
eurjchem-885	189	18	.	.	PUNCT
eurjchem-885	190	1	pharmaceutical	pharmaceutical	ADJ
eurjchem-885	190	2	preparation	preparation	NOUN
eurjchem-885	190	3	%	%	NOUN
eurjchem-885	190	4	found	find	VERB
eurjchem-885	190	5	*	*	PROPN
eurjchem-885	190	6	,	,	PUNCT
eurjchem-885	190	7	mean±	mean±	PROPN
eurjchem-885	190	8	sd	sd	ADP
eurjchem-885	190	9	proposed	propose	VERB
eurjchem-885	190	10	reference	reference	NOUN
eurjchem-885	190	11	[	[	X
eurjchem-885	190	12	2	2	NUM
eurjchem-885	190	13	]	]	PUNCT
eurjchem-885	190	14	itrapex	itrapex	NOUN
eurjchem-885	190	15	cap	cap	NOUN
eurjchem-885	190	16	99.3±1.2	99.3±1.2	NUM
eurjchem-885	190	17	99.6±1.5	99.6±1.5	NUM
eurjchem-885	190	18	t	t	NOUN
eurjchem-885	190	19	*	*	PUNCT
eurjchem-885	190	20	*	*	PUNCT
eurjchem-885	190	21	0.3	0.3	NUM
eurjchem-885	190	22	‐	‐	NOUN
eurjchem-885	190	23	f	f	PROPN
eurjchem-885	190	24	*	*	PUNCT
eurjchem-885	190	25	*	*	PUNCT
eurjchem-885	190	26	1.7	1.7	NUM
eurjchem-885	190	27	‐	‐	ADJ
eurjchem-885	190	28	itranox	itranox	NOUN
eurjchem-885	190	29	cap	cap	NOUN
eurjchem-885	190	30	105.1±0.5	105.1±0.5	NUM
eurjchem-885	190	31	104.4±0.8	104.4±0.8	NUM
eurjchem-885	190	32	t	t	NOUN
eurjchem-885	190	33	*	*	PUNCT
eurjchem-885	190	34	*	*	PUNCT
eurjchem-885	190	35	0.3	0.3	NUM
eurjchem-885	190	36	‐	‐	NOUN
eurjchem-885	190	37	f	f	PROPN
eurjchem-885	190	38	*	*	PUNCT
eurjchem-885	190	39	*	*	PUNCT
eurjchem-885	190	40	2.3	2.3	NUM
eurjchem-885	190	41	‐	‐	ADJ
eurjchem-885	190	42	itracon	itracon	NOUN
eurjchem-885	190	43	cap	cap	VERB
eurjchem-885	190	44	106.4±0.6	106.4±0.6	NUM
eurjchem-885	190	45	106.6±0.6	106.6±0.6	NOUN
eurjchem-885	190	46	t	t	NOUN
eurjchem-885	190	47	*	*	PUNCT
eurjchem-885	190	48	*	*	PUNCT
eurjchem-885	190	49	0.4	0.4	NUM
eurjchem-885	190	50	‐	‐	NOUN
eurjchem-885	190	51	f	f	PROPN
eurjchem-885	190	52	*	*	PUNCT
eurjchem-885	190	53	*	*	PUNCT
eurjchem-885	190	54	1.2	1.2	NUM
eurjchem-885	190	55	‐	‐	NOUN
eurjchem-885	190	56	*	*	VERB
eurjchem-885	190	57	each	each	DET
eurjchem-885	190	58	result	result	NOUN
eurjchem-885	190	59	is	be	AUX
eurjchem-885	190	60	the	the	DET
eurjchem-885	190	61	average	average	NOUN
eurjchem-885	190	62	of	of	ADP
eurjchem-885	190	63	five	five	NUM
eurjchem-885	190	64	separate	separate	ADJ
eurjchem-885	190	65	determinations	determination	NOUN
eurjchem-885	190	66	and	and	CCONJ
eurjchem-885	190	67	each	each	DET
eurjchem-885	190	68	one	one	NUM
eurjchem-885	190	69	repeated	repeat	VERB
eurjchem-885	190	70	three	three	NUM
eurjchem-885	190	71	times	time	NOUN
eurjchem-885	190	72	.	.	PUNCT
eurjchem-885	191	1	*	*	PUNCT
eurjchem-885	191	2	*	*	PUNCT
eurjchem-885	191	3	the	the	DET
eurjchem-885	191	4	tabulated	tabulate	VERB
eurjchem-885	191	5	t	t	NOUN
eurjchem-885	191	6	=	=	SYM
eurjchem-885	191	7	1.9	1.9	NUM
eurjchem-885	191	8	and	and	CCONJ
eurjchem-885	191	9	f	f	NOUN
eurjchem-885	191	10	=	=	SYM
eurjchem-885	191	11	6.4	6.4	NUM
eurjchem-885	191	12	at	at	ADP
eurjchem-885	191	13	n	n	PROPN
eurjchem-885	191	14	=	=	SYM
eurjchem-885	191	15	15	15	NUM
eurjchem-885	191	16	and	and	CCONJ
eurjchem-885	191	17	p	p	X
eurjchem-885	191	18	=	=	NOUN
eurjchem-885	191	19	0.05	0.05	NUM
eurjchem-885	191	20	[	[	X
eurjchem-885	191	21	26	26	NUM
eurjchem-885	191	22	]	]	PUNCT
eurjchem-885	191	23	.	.	PUNCT
eurjchem-885	192	1	16	16	NUM
eurjchem-885	192	2	rizk	rizk	PROPN
eurjchem-885	192	3	et	et	PROPN
eurjchem-885	192	4	al	al	PROPN
eurjchem-885	192	5	.	.	PUNCT
eurjchem-885	192	6	/	/	SYM
eurjchem-885	192	7	european	european	PROPN
eurjchem-885	192	8	journal	journal	PROPN
eurjchem-885	192	9	of	of	ADP
eurjchem-885	192	10	chemistry	chemistry	NOUN
eurjchem-885	192	11	5	5	NUM
eurjchem-885	192	12	(	(	PUNCT
eurjchem-885	192	13	1	1	NUM
eurjchem-885	192	14	)	)	PUNCT
eurjchem-885	192	15	(	(	PUNCT
eurjchem-885	192	16	2014	2014	NUM
eurjchem-885	192	17	)	)	PUNCT
eurjchem-885	192	18	11‐17	11‐17	ADJ
eurjchem-885	192	19	table	table	NOUN
eurjchem-885	192	20	6	6	NUM
eurjchem-885	192	21	.	.	PUNCT
eurjchem-885	193	1	assay	assay	NOUN
eurjchem-885	193	2	results	result	NOUN
eurjchem-885	193	3	for	for	ADP
eurjchem-885	193	4	the	the	DET
eurjchem-885	193	5	determination	determination	NOUN
eurjchem-885	193	6	of	of	ADP
eurjchem-885	193	7	itc	itc	PROPN
eurjchem-885	193	8	in	in	ADP
eurjchem-885	193	9	spiked	spiked	ADJ
eurjchem-885	193	10	human	human	ADJ
eurjchem-885	193	11	plasma	plasma	NOUN
eurjchem-885	193	12	using	use	VERB
eurjchem-885	193	13	the	the	DET
eurjchem-885	193	14	proposed	propose	VERB
eurjchem-885	193	15	method	method	NOUN
eurjchem-885	193	16	.	.	PUNCT
eurjchem-885	194	1	parameter	parameter	PROPN
eurjchem-885	194	2	conc	conc	PROPN
eurjchem-885	194	3	.	.	PUNCT
eurjchem-885	195	1	added	add	VERB
eurjchem-885	195	2	(	(	PUNCT
eurjchem-885	195	3	µg	µg	ADJ
eurjchem-885	195	4	/	/	SYM
eurjchem-885	195	5	ml	ml	NOUN
eurjchem-885	195	6	)	)	PUNCT
eurjchem-885	195	7	conc	conc	NOUN
eurjchem-885	195	8	.	.	PUNCT
eurjchem-885	196	1	found	find	VERB
eurjchem-885	196	2	(	(	PUNCT
eurjchem-885	196	3	µg	µg	ADJ
eurjchem-885	196	4	/	/	SYM
eurjchem-885	196	5	ml	ml	NOUN
eurjchem-885	196	6	)	)	PUNCT
eurjchem-885	196	7	%	%	NOUN
eurjchem-885	196	8	recovery	recovery	NOUN
eurjchem-885	196	9	*	*	PUNCT
eurjchem-885	196	10	spiked	spiked	ADJ
eurjchem-885	196	11	plasma	plasma	NOUN
eurjchem-885	196	12	125	125	NUM
eurjchem-885	196	13	125.4	125.4	NUM
eurjchem-885	196	14	100.3	100.3	NUM
eurjchem-885	196	15	150	150	NUM
eurjchem-885	196	16	145.6	145.6	NUM
eurjchem-885	196	17	97.1	97.1	NUM
eurjchem-885	196	18	175	175	NUM
eurjchem-885	196	19	166.2	166.2	NUM
eurjchem-885	196	20	94.9	94.9	NUM
eurjchem-885	196	21	mean	mean	NOUN
eurjchem-885	196	22	%	%	NOUN
eurjchem-885	196	23	±sd	±sd	PRON
eurjchem-885	196	24	97.5±2.7	97.5±2.7	NUM
eurjchem-885	196	25	%	%	NOUN
eurjchem-885	196	26	r.s.d	r.s.d	VERB
eurjchem-885	196	27	2.8	2.8	NUM
eurjchem-885	196	28	%	%	NOUN
eurjchem-885	196	29	error	error	NOUN
eurjchem-885	196	30	0.9	0.9	NUM
eurjchem-885	196	31	*	*	PUNCT
eurjchem-885	196	32	each	each	DET
eurjchem-885	196	33	result	result	NOUN
eurjchem-885	196	34	is	be	AUX
eurjchem-885	196	35	the	the	DET
eurjchem-885	196	36	average	average	NOUN
eurjchem-885	196	37	of	of	ADP
eurjchem-885	196	38	three	three	NUM
eurjchem-885	196	39	separate	separate	ADJ
eurjchem-885	196	40	determinations	determination	NOUN
eurjchem-885	196	41	.	.	PUNCT
eurjchem-885	197	1	3.5.3	3.5.3	NUM
eurjchem-885	197	2	.	.	PUNCT
eurjchem-885	197	3	results	result	NOUN
eurjchem-885	197	4	of	of	ADP
eurjchem-885	197	5	stress	stress	NOUN
eurjchem-885	197	6	testing	testing	NOUN
eurjchem-885	197	7	studies	study	NOUN
eurjchem-885	197	8	stability	stability	NOUN
eurjchem-885	197	9	testing	testing	NOUN
eurjchem-885	197	10	of	of	ADP
eurjchem-885	197	11	itc	itc	PROPN
eurjchem-885	197	12	was	be	AUX
eurjchem-885	197	13	performed	perform	VERB
eurjchem-885	197	14	under	under	ADP
eurjchem-885	197	15	various	various	ADJ
eurjchem-885	197	16	stress	stress	NOUN
eurjchem-885	197	17	conditions	condition	NOUN
eurjchem-885	197	18	in	in	ADP
eurjchem-885	197	19	order	order	NOUN
eurjchem-885	197	20	to	to	PART
eurjchem-885	197	21	assure	assure	VERB
eurjchem-885	197	22	the	the	DET
eurjchem-885	197	23	selectivity	selectivity	NOUN
eurjchem-885	197	24	and	and	CCONJ
eurjchem-885	197	25	provide	provide	VERB
eurjchem-885	197	26	an	an	DET
eurjchem-885	197	27	indication	indication	NOUN
eurjchem-885	197	28	of	of	ADP
eurjchem-885	197	29	the	the	DET
eurjchem-885	197	30	stability‐indicating	stability‐indicate	VERB
eurjchem-885	197	31	properties	property	NOUN
eurjchem-885	197	32	of	of	ADP
eurjchem-885	197	33	the	the	DET
eurjchem-885	197	34	proposed	propose	VERB
eurjchem-885	197	35	mlc	mlc	NOUN
eurjchem-885	197	36	method	method	NOUN
eurjchem-885	197	37	.	.	PUNCT
eurjchem-885	198	1	the	the	DET
eurjchem-885	198	2	studied	study	VERB
eurjchem-885	198	3	compound	compound	NOUN
eurjchem-885	198	4	is	be	AUX
eurjchem-885	198	5	found	find	VERB
eurjchem-885	198	6	to	to	PART
eurjchem-885	198	7	be	be	AUX
eurjchem-885	198	8	highly	highly	ADV
eurjchem-885	198	9	labile	labile	ADJ
eurjchem-885	198	10	to	to	PART
eurjchem-885	198	11	alkaline	alkaline	NOUN
eurjchem-885	198	12	hydrolysis	hydrolysis	NOUN
eurjchem-885	198	13	which	which	PRON
eurjchem-885	198	14	resulted	result	VERB
eurjchem-885	198	15	in	in	ADP
eurjchem-885	198	16	about	about	ADP
eurjchem-885	198	17	85	85	NUM
eurjchem-885	198	18	and	and	CCONJ
eurjchem-885	198	19	82	82	NUM
eurjchem-885	198	20	%	%	NOUN
eurjchem-885	198	21	degradation	degradation	NOUN
eurjchem-885	198	22	of	of	ADP
eurjchem-885	198	23	itc	itc	PROPN
eurjchem-885	198	24	in	in	ADP
eurjchem-885	198	25	itrapex	itrapex	PROPN
eurjchem-885	198	26	and	and	CCONJ
eurjchem-885	198	27	itracon	itracon	PROPN
eurjchem-885	198	28	capsule	capsule	PROPN
eurjchem-885	198	29	,	,	PUNCT
eurjchem-885	198	30	respectively	respectively	ADV
eurjchem-885	198	31	,	,	PUNCT
eurjchem-885	198	32	while	while	SCONJ
eurjchem-885	198	33	the	the	DET
eurjchem-885	198	34	peak	peak	NOUN
eurjchem-885	198	35	of	of	ADP
eurjchem-885	198	36	itc	itc	PROPN
eurjchem-885	198	37	in	in	ADP
eurjchem-885	198	38	itranox	itranox	PROPN
eurjchem-885	198	39	capsule	capsule	NOUN
eurjchem-885	198	40	was	be	AUX
eurjchem-885	198	41	nearly	nearly	ADV
eurjchem-885	198	42	diminished	diminish	VERB
eurjchem-885	198	43	as	as	SCONJ
eurjchem-885	198	44	illustrated	illustrate	VERB
eurjchem-885	198	45	in	in	ADP
eurjchem-885	198	46	figure	figure	NOUN
eurjchem-885	198	47	6	6	NUM
eurjchem-885	198	48	.	.	PUNCT
eurjchem-885	198	49	where	where	SCONJ
eurjchem-885	198	50	the	the	DET
eurjchem-885	198	51	acidic	acidic	ADJ
eurjchem-885	198	52	degradation	degradation	NOUN
eurjchem-885	198	53	using	use	VERB
eurjchem-885	198	54	1	1	NUM
eurjchem-885	198	55	n	n	PRON
eurjchem-885	198	56	hcl	hcl	PROPN
eurjchem-885	198	57	for	for	ADP
eurjchem-885	198	58	24	24	NUM
eurjchem-885	198	59	hrs	hrs	NOUN
eurjchem-885	198	60	showed	show	VERB
eurjchem-885	198	61	that	that	SCONJ
eurjchem-885	198	62	about	about	ADP
eurjchem-885	198	63	10	10	NUM
eurjchem-885	198	64	%	%	NOUN
eurjchem-885	198	65	degradation	degradation	NOUN
eurjchem-885	198	66	in	in	ADP
eurjchem-885	198	67	the	the	DET
eurjchem-885	198	68	three	three	NUM
eurjchem-885	198	69	dosage	dosage	NOUN
eurjchem-885	198	70	forms	form	NOUN
eurjchem-885	198	71	as	as	SCONJ
eurjchem-885	198	72	illustrated	illustrate	VERB
eurjchem-885	198	73	in	in	ADP
eurjchem-885	198	74	figure	figure	NOUN
eurjchem-885	198	75	7	7	NUM
eurjchem-885	198	76	.	.	PUNCT
eurjchem-885	198	77	exposure	exposure	NOUN
eurjchem-885	198	78	of	of	ADP
eurjchem-885	198	79	itc	itc	PROPN
eurjchem-885	198	80	capsules	capsule	NOUN
eurjchem-885	198	81	to	to	PART
eurjchem-885	198	82	oxidative	oxidative	VERB
eurjchem-885	198	83	degradation	degradation	NOUN
eurjchem-885	198	84	by	by	ADP
eurjchem-885	198	85	30	30	NUM
eurjchem-885	198	86	%	%	NOUN
eurjchem-885	198	87	h2o2	h2o2	NOUN
eurjchem-885	198	88	for	for	ADP
eurjchem-885	198	89	24	24	NUM
eurjchem-885	198	90	hrs	hrs	NOUN
eurjchem-885	198	91	,	,	PUNCT
eurjchem-885	198	92	about	about	ADV
eurjchem-885	198	93	69	69	NUM
eurjchem-885	198	94	,	,	PUNCT
eurjchem-885	198	95	63	63	NUM
eurjchem-885	198	96	and	and	CCONJ
eurjchem-885	198	97	65	65	NUM
eurjchem-885	198	98	%	%	NOUN
eurjchem-885	198	99	degradation	degradation	NOUN
eurjchem-885	198	100	of	of	ADP
eurjchem-885	198	101	itc	itc	PROPN
eurjchem-885	198	102	in	in	ADP
eurjchem-885	198	103	itrapex	itrapex	PROPN
eurjchem-885	198	104	cap	cap	NOUN
eurjchem-885	198	105	.	.	PUNCT
eurjchem-885	199	1	,	,	PUNCT
eurjchem-885	199	2	itranox	itranox	NOUN
eurjchem-885	199	3	cap	cap	NOUN
eurjchem-885	199	4	.	.	PUNCT
eurjchem-885	200	1	and	and	CCONJ
eurjchem-885	200	2	iracon	iracon	NOUN
eurjchem-885	200	3	cap	cap	NOUN
eurjchem-885	200	4	.	.	PUNCT
eurjchem-885	200	5	,	,	PUNCT
eurjchem-885	200	6	respectively	respectively	ADV
eurjchem-885	200	7	,	,	PUNCT
eurjchem-885	200	8	as	as	SCONJ
eurjchem-885	200	9	illustrated	illustrate	VERB
eurjchem-885	200	10	in	in	ADP
eurjchem-885	200	11	figure	figure	NOUN
eurjchem-885	200	12	8	8	NUM
eurjchem-885	200	13	.	.	PUNCT
eurjchem-885	201	1	itc	itc	PROPN
eurjchem-885	201	2	did	do	AUX
eurjchem-885	201	3	not	not	PART
eurjchem-885	201	4	exhibit	exhibit	VERB
eurjchem-885	201	5	any	any	DET
eurjchem-885	201	6	degradation	degradation	NOUN
eurjchem-885	201	7	peaks	peak	NOUN
eurjchem-885	201	8	that	that	PRON
eurjchem-885	201	9	could	could	AUX
eurjchem-885	201	10	interfere	interfere	VERB
eurjchem-885	201	11	with	with	ADP
eurjchem-885	201	12	the	the	DET
eurjchem-885	201	13	proposed	propose	VERB
eurjchem-885	201	14	mlc	mlc	NOUN
eurjchem-885	201	15	method	method	NOUN
eurjchem-885	201	16	.	.	PUNCT
eurjchem-885	202	1	no	no	DET
eurjchem-885	202	2	degradation	degradation	NOUN
eurjchem-885	202	3	was	be	AUX
eurjchem-885	202	4	seen	see	VERB
eurjchem-885	202	5	under	under	ADP
eurjchem-885	202	6	photolytic	photolytic	ADJ
eurjchem-885	202	7	conditions	condition	NOUN
eurjchem-885	202	8	.	.	PUNCT
eurjchem-885	203	1	figure	figure	NOUN
eurjchem-885	203	2	6	6	NUM
eurjchem-885	203	3	.	.	PUNCT
eurjchem-885	203	4	alkaline	alkaline	NOUN
eurjchem-885	203	5	degradation	degradation	NOUN
eurjchem-885	203	6	of	of	ADP
eurjchem-885	203	7	200	200	NUM
eurjchem-885	203	8	µg	µg	ADJ
eurjchem-885	203	9	/	/	SYM
eurjchem-885	203	10	ml	ml	NOUN
eurjchem-885	203	11	itc	itc	PROPN
eurjchem-885	203	12	in	in	ADP
eurjchem-885	203	13	its	its	PRON
eurjchem-885	203	14	three	three	NUM
eurjchem-885	203	15	dosage	dosage	NOUN
eurjchem-885	203	16	forms	form	NOUN
eurjchem-885	203	17	.	.	PUNCT
eurjchem-885	204	1	4	4	X
eurjchem-885	204	2	.	.	X
eurjchem-885	204	3	conclusion	conclusion	NOUN
eurjchem-885	204	4	the	the	DET
eurjchem-885	204	5	proposed	propose	VERB
eurjchem-885	204	6	mlc	mlc	NOUN
eurjchem-885	204	7	method	method	NOUN
eurjchem-885	204	8	represents	represent	VERB
eurjchem-885	204	9	a	a	DET
eurjchem-885	204	10	new	new	ADJ
eurjchem-885	204	11	rapid	rapid	ADJ
eurjchem-885	204	12	and	and	CCONJ
eurjchem-885	204	13	sensitive	sensitive	ADJ
eurjchem-885	204	14	stability‐indicating	stability‐indicating	NOUN
eurjchem-885	204	15	assay	assay	NOUN
eurjchem-885	204	16	for	for	ADP
eurjchem-885	204	17	the	the	DET
eurjchem-885	204	18	determination	determination	NOUN
eurjchem-885	204	19	of	of	ADP
eurjchem-885	204	20	itc	itc	PROPN
eurjchem-885	204	21	in	in	ADP
eurjchem-885	204	22	bulk	bulk	ADJ
eurjchem-885	204	23	and	and	CCONJ
eurjchem-885	204	24	commercial	commercial	ADJ
eurjchem-885	204	25	capsules	capsule	NOUN
eurjchem-885	204	26	.	.	PUNCT
eurjchem-885	205	1	the	the	DET
eurjchem-885	205	2	proposed	propose	VERB
eurjchem-885	205	3	method	method	NOUN
eurjchem-885	205	4	was	be	AUX
eurjchem-885	205	5	applied	apply	VERB
eurjchem-885	205	6	successfully	successfully	ADV
eurjchem-885	205	7	for	for	ADP
eurjchem-885	205	8	the	the	DET
eurjchem-885	205	9	determination	determination	NOUN
eurjchem-885	205	10	of	of	ADP
eurjchem-885	205	11	itc	itc	PROPN
eurjchem-885	205	12	in	in	ADP
eurjchem-885	205	13	human	human	ADJ
eurjchem-885	205	14	plasma	plasma	NOUN
eurjchem-885	205	15	with	with	ADP
eurjchem-885	205	16	no	no	DET
eurjchem-885	205	17	need	need	NOUN
eurjchem-885	205	18	for	for	ADP
eurjchem-885	205	19	tedious	tedious	ADJ
eurjchem-885	205	20	sample	sample	NOUN
eurjchem-885	205	21	pre‐treatment	pre‐treatment	NOUN
eurjchem-885	205	22	steps	step	NOUN
eurjchem-885	205	23	.	.	PUNCT
eurjchem-885	206	1	in	in	ADP
eurjchem-885	206	2	addition	addition	NOUN
eurjchem-885	206	3	,	,	PUNCT
eurjchem-885	206	4	the	the	DET
eurjchem-885	206	5	proposed	propose	VERB
eurjchem-885	206	6	method	method	NOUN
eurjchem-885	206	7	was	be	AUX
eurjchem-885	206	8	extended	extend	VERB
eurjchem-885	206	9	to	to	PART
eurjchem-885	206	10	investigate	investigate	VERB
eurjchem-885	206	11	the	the	DET
eurjchem-885	206	12	inherent	inherent	ADJ
eurjchem-885	206	13	stability	stability	NOUN
eurjchem-885	206	14	of	of	ADP
eurjchem-885	206	15	itc	itc	PROPN
eurjchem-885	206	16	under	under	ADP
eurjchem-885	206	17	different	different	ADJ
eurjchem-885	206	18	stress	stress	NOUN
eurjchem-885	206	19	conditions	condition	NOUN
eurjchem-885	206	20	.	.	PUNCT
eurjchem-885	207	1	figure	figure	VERB
eurjchem-885	207	2	7	7	NUM
eurjchem-885	207	3	.	.	PUNCT
eurjchem-885	207	4	acidic	acidic	ADJ
eurjchem-885	207	5	degradation	degradation	NOUN
eurjchem-885	207	6	of	of	ADP
eurjchem-885	207	7	200	200	NUM
eurjchem-885	207	8	µg	µg	ADJ
eurjchem-885	207	9	/	/	SYM
eurjchem-885	207	10	ml	ml	NOUN
eurjchem-885	207	11	itc	itc	PROPN
eurjchem-885	207	12	in	in	ADP
eurjchem-885	207	13	its	its	PRON
eurjchem-885	207	14	three	three	NUM
eurjchem-885	207	15	dosage	dosage	NOUN
eurjchem-885	207	16	forms	form	NOUN
eurjchem-885	207	17	.	.	PUNCT
eurjchem-885	208	1	figure	figure	NOUN
eurjchem-885	208	2	8	8	NUM
eurjchem-885	208	3	.	.	PUNCT
eurjchem-885	208	4	oxidative	oxidative	ADJ
eurjchem-885	208	5	degradation	degradation	NOUN
eurjchem-885	208	6	of	of	ADP
eurjchem-885	208	7	200	200	NUM
eurjchem-885	208	8	µg	µg	ADJ
eurjchem-885	208	9	/	/	SYM
eurjchem-885	208	10	ml	ml	NOUN
eurjchem-885	208	11	itc	itc	PROPN
eurjchem-885	208	12	in	in	ADP
eurjchem-885	208	13	its	its	PRON
eurjchem-885	208	14	three	three	NUM
eurjchem-885	208	15	dosage	dosage	NOUN
eurjchem-885	208	16	forms	form	NOUN
eurjchem-885	208	17	.	.	PUNCT
eurjchem-885	209	1	rizk	rizk	PROPN
eurjchem-885	209	2	et	et	PROPN
eurjchem-885	209	3	al	al	PROPN
eurjchem-885	209	4	.	.	PUNCT
eurjchem-885	209	5	/	/	SYM
eurjchem-885	209	6	european	european	PROPN
eurjchem-885	209	7	journal	journal	PROPN
eurjchem-885	209	8	of	of	ADP
eurjchem-885	209	9	chemistry	chemistry	NOUN
eurjchem-885	209	10	5	5	NUM
eurjchem-885	209	11	(	(	PUNCT
eurjchem-885	209	12	1	1	NUM
eurjchem-885	209	13	)	)	PUNCT
eurjchem-885	209	14	(	(	PUNCT
eurjchem-885	209	15	2014	2014	NUM
eurjchem-885	209	16	)	)	PUNCT
eurjchem-885	209	17	11‐17	11‐17	NOUN
eurjchem-885	209	18	17	17	NUM
eurjchem-885	209	19	acknowledgements	acknowledgement	NOUN
eurjchem-885	209	20	the	the	DET
eurjchem-885	209	21	authors	author	NOUN
eurjchem-885	209	22	thank	thank	VERB
eurjchem-885	209	23	egyptian	egyptian	ADJ
eurjchem-885	209	24	research	research	PROPN
eurjchem-885	209	25	and	and	CCONJ
eurjchem-885	209	26	development	development	NOUN
eurjchem-885	209	27	company	company	NOUN
eurjchem-885	209	28	for	for	ADP
eurjchem-885	209	29	kindly	kindly	ADV
eurjchem-885	209	30	effort	effort	NOUN
eurjchem-885	209	31	providing	provide	VERB
eurjchem-885	209	32	during	during	ADP
eurjchem-885	209	33	this	this	DET
eurjchem-885	209	34	work	work	NOUN
eurjchem-885	209	35	.	.	PUNCT
eurjchem-885	210	1	references	reference	NOUN
eurjchem-885	210	2	[	[	X
eurjchem-885	210	3	1	1	NUM
eurjchem-885	210	4	]	]	PUNCT
eurjchem-885	210	5	.	.	PUNCT
eurjchem-885	211	1	ghannoum	ghannoum	PROPN
eurjchem-885	211	2	,	,	PUNCT
eurjchem-885	211	3	m.	m.	NOUN
eurjchem-885	211	4	a.	a.	PROPN
eurjchem-885	211	5	;	;	PUNCT
eurjchem-885	211	6	rice	rice	PROPN
eurjchem-885	211	7	,	,	PUNCT
eurjchem-885	211	8	l.	l.	PROPN
eurjchem-885	211	9	b.	b.	PROPN
eurjchem-885	211	10	clin	clin	PROPN
eurjchem-885	211	11	.	.	PUNCT
eurjchem-885	212	1	microbiol	microbiol	PROPN
eurjchem-885	212	2	.	.	PUNCT
eurjchem-885	213	1	rev	rev	PROPN
eurjchem-885	213	2	.	.	PROPN
eurjchem-885	213	3	1999	1999	NUM
eurjchem-885	213	4	,	,	PUNCT
eurjchem-885	213	5	12	12	NUM
eurjchem-885	213	6	,	,	PUNCT
eurjchem-885	213	7	501‐517	501‐517	PROPN
eurjchem-885	213	8	.	.	PUNCT
eurjchem-885	214	1	[	[	X
eurjchem-885	214	2	2	2	NUM
eurjchem-885	214	3	]	]	PUNCT
eurjchem-885	214	4	.	.	PUNCT
eurjchem-885	215	1	british	british	PROPN
eurjchem-885	215	2	pharmacopoeia	pharmacopoeia	PROPN
eurjchem-885	215	3	,	,	PUNCT
eurjchem-885	215	4	british	british	ADJ
eurjchem-885	215	5	pharmacopoeia	pharmacopoeia	PROPN
eurjchem-885	215	6	commission	commission	PROPN
eurjchem-885	215	7	,	,	PUNCT
eurjchem-885	215	8	the	the	DET
eurjchem-885	215	9	stationery	stationery	NOUN
eurjchem-885	215	10	office	office	NOUN
eurjchem-885	215	11	,	,	PUNCT
eurjchem-885	215	12	london	london	PROPN
eurjchem-885	215	13	,	,	PUNCT
eurjchem-885	215	14	uk	uk	PROPN
eurjchem-885	215	15	,	,	PUNCT
eurjchem-885	215	16	2012	2012	NUM
eurjchem-885	215	17	.	.	PUNCT
eurjchem-885	216	1	[	[	X
eurjchem-885	216	2	3	3	NUM
eurjchem-885	216	3	]	]	PUNCT
eurjchem-885	216	4	.	.	PUNCT
eurjchem-885	217	1	european	european	PROPN
eurjchem-885	217	2	pharmacopoeia	pharmacopoeia	PROPN
eurjchem-885	217	3	,	,	PUNCT
eurjchem-885	217	4	5th	5th	ADJ
eurjchem-885	217	5	ed	ed	NOUN
eurjchem-885	217	6	.	.	PUNCT
eurjchem-885	218	1	supplements	supplement	NOUN
eurjchem-885	218	2	1‐5	1‐5	PROPN
eurjchem-885	218	3	.	.	PUNCT
eurjchem-885	219	1	strasbourg	strasbourg	PROPN
eurjchem-885	219	2	,	,	PUNCT
eurjchem-885	219	3	council	council	PROPN
eurjchem-885	219	4	of	of	ADP
eurjchem-885	219	5	europe	europe	PROPN
eurjchem-885	219	6	,	,	PUNCT
eurjchem-885	219	7	2005‐2006	2005‐2006	NUM
eurjchem-885	219	8	.	.	PUNCT
eurjchem-885	220	1	[	[	X
eurjchem-885	220	2	4	4	NUM
eurjchem-885	220	3	]	]	PUNCT
eurjchem-885	220	4	.	.	PUNCT
eurjchem-885	221	1	miura	miura	PROPN
eurjchem-885	221	2	,	,	PUNCT
eurjchem-885	221	3	m.	m.	NOUN
eurjchem-885	221	4	;	;	PUNCT
eurjchem-885	221	5	takahashi	takahashi	PROPN
eurjchem-885	221	6	,	,	PUNCT
eurjchem-885	221	7	n.	n.	PROPN
eurjchem-885	221	8	;	;	PUNCT
eurjchem-885	221	9	nara	nara	PROPN
eurjchem-885	221	10	,	,	PUNCT
eurjchem-885	221	11	m.	m.	NOUN
eurjchem-885	221	12	;	;	PUNCT
eurjchem-885	221	13	fujishima	fujishima	PROPN
eurjchem-885	221	14	,	,	PUNCT
eurjchem-885	221	15	n.	n.	NOUN
eurjchem-885	221	16	;	;	PUNCT
eurjchem-885	221	17	kagaya	kagaya	PROPN
eurjchem-885	221	18	,	,	PUNCT
eurjchem-885	221	19	h.	h.	PROPN
eurjchem-885	221	20	;	;	PUNCT
eurjchem-885	221	21	kameoka	kameoka	NOUN
eurjchem-885	221	22	,	,	PUNCT
eurjchem-885	221	23	y.	y.	PROPN
eurjchem-885	221	24	ann	ann	PROPN
eurjchem-885	221	25	.	.	PUNCT
eurjchem-885	222	1	clin	clin	PROPN
eurjchem-885	222	2	.	.	PUNCT
eurjchem-885	223	1	biochem	biochem	PROPN
eurjchem-885	223	2	.	.	PUNCT
eurjchem-885	224	1	2010	2010	NUM
eurjchem-885	224	2	,	,	PUNCT
eurjchem-885	224	3	47	47	NUM
eurjchem-885	224	4	,	,	PUNCT
eurjchem-885	224	5	432‐439	432‐439	NOUN
eurjchem-885	224	6	.	.	PUNCT
eurjchem-885	225	1	[	[	X
eurjchem-885	225	2	5	5	NUM
eurjchem-885	225	3	]	]	PUNCT
eurjchem-885	225	4	.	.	PUNCT
eurjchem-885	226	1	gagliardi	gagliardi	PROPN
eurjchem-885	226	2	,	,	PUNCT
eurjchem-885	226	3	l.	l.	PROPN
eurjchem-885	226	4	;	;	PUNCT
eurjchem-885	226	5	de‐orsi	de‐orsi	PROPN
eurjchem-885	226	6	,	,	PUNCT
eurjchem-885	226	7	d.	d.	PROPN
eurjchem-885	226	8	;	;	PUNCT
eurjchem-885	226	9	chimenti	chimenti	X
eurjchem-885	226	10	,	,	PUNCT
eurjchem-885	226	11	p.	p.	NOUN
eurjchem-885	226	12	;	;	PUNCT
eurjchem-885	226	13	porra	porra	PROPN
eurjchem-885	226	14	,	,	PUNCT
eurjchem-885	226	15	r.	r.	PROPN
eurjchem-885	226	16	;	;	PUNCT
eurjchem-885	226	17	tonelli	tonelli	PROPN
eurjchem-885	226	18	,	,	PUNCT
eurjchem-885	226	19	d.	d.	PROPN
eurjchem-885	226	20	anal	anal	PROPN
eurjchem-885	226	21	.	.	PUNCT
eurjchem-885	227	1	sci	sci	PROPN
eurjchem-885	227	2	.	.	PROPN
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eurjchem-885	227	4	,	,	PUNCT
eurjchem-885	227	5	19	19	NUM
eurjchem-885	227	6	,	,	PUNCT
eurjchem-885	227	7	1195‐1197	1195‐1197	NUM
eurjchem-885	227	8	.	.	PUNCT
eurjchem-885	228	1	[	[	X
eurjchem-885	228	2	6	6	NUM
eurjchem-885	228	3	]	]	PUNCT
eurjchem-885	228	4	.	.	PUNCT
eurjchem-885	229	1	ohkubo	ohkubo	NOUN
eurjchem-885	229	2	,	,	PUNCT
eurjchem-885	229	3	t.	t.	PROPN
eurjchem-885	229	4	;	;	PUNCT
eurjchem-885	229	5	osanai	osanai	VERB
eurjchem-885	229	6	,	,	PUNCT
eurjchem-885	229	7	t.	t.	PROPN
eurjchem-885	229	8	ann	ann	PROPN
eurjchem-885	229	9	.	.	PUNCT
eurjchem-885	230	1	clin	clin	PROPN
eurjchem-885	230	2	.	.	PUNCT
eurjchem-885	231	1	biochem	biochem	PROPN
eurjchem-885	231	2	.	.	PUNCT
eurjchem-885	232	1	2005	2005	NUM
eurjchem-885	232	2	,	,	PUNCT
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eurjchem-885	232	4	,	,	PUNCT
eurjchem-885	232	5	94‐98	94‐98	NUM
eurjchem-885	232	6	.	.	PUNCT
eurjchem-885	233	1	[	[	X
eurjchem-885	233	2	7	7	NUM
eurjchem-885	233	3	]	]	PUNCT
eurjchem-885	233	4	.	.	PUNCT
eurjchem-885	233	5	khoschsorur	khoschsorur	PROPN
eurjchem-885	233	6	,	,	PUNCT
eurjchem-885	233	7	g.	g.	PROPN
eurjchem-885	233	8	;	;	PUNCT
eurjchem-885	233	9	fruehwirth	fruehwirth	NOUN
eurjchem-885	233	10	,	,	PUNCT
eurjchem-885	233	11	f.	f.	PROPN
eurjchem-885	233	12	;	;	PUNCT
eurjchem-885	233	13	zelzer	zelzer	PROPN
eurjchem-885	233	14	,	,	PUNCT
eurjchem-885	233	15	s.	s.	PROPN
eurjchem-885	233	16	antimicrob	antimicrob	PROPN
eurjchem-885	233	17	.	.	PUNCT
eurjchem-885	234	1	agents	agents	PROPN
eurjchem-885	234	2	chemother	chemother	PROPN
eurjchem-885	234	3	.	.	PUNCT
eurjchem-885	235	1	2005	2005	NUM
eurjchem-885	235	2	,	,	PUNCT
eurjchem-885	235	3	49	49	NUM
eurjchem-885	235	4	,	,	PUNCT
eurjchem-885	235	5	3569‐3571	3569‐3571	NUM
eurjchem-885	235	6	.	.	PUNCT
eurjchem-885	236	1	[	[	X
eurjchem-885	236	2	8	8	NUM
eurjchem-885	236	3	]	]	PUNCT
eurjchem-885	236	4	.	.	PUNCT
eurjchem-885	237	1	yoo	yoo	PROPN
eurjchem-885	237	2	,	,	PUNCT
eurjchem-885	237	3	s.	s.	PROPN
eurjchem-885	237	4	d.	d.	PROPN
eurjchem-885	237	5	;	;	PUNCT
eurjchem-885	237	6	lee	lee	PROPN
eurjchem-885	237	7	,	,	PUNCT
eurjchem-885	237	8	s.	s.	PROPN
eurjchem-885	237	9	h.	h.	PROPN
eurjchem-885	237	10	;	;	PUNCT
eurjchem-885	237	11	kang	kang	PROPN
eurjchem-885	237	12	,	,	PUNCT
eurjchem-885	237	13	e.	e.	PROPN
eurjchem-885	237	14	;	;	PUNCT
eurjchem-885	237	15	jun	jun	PROPN
eurjchem-885	237	16	,	,	PUNCT
eurjchem-885	237	17	h.	h.	PROPN
eurjchem-885	237	18	;	;	PUNCT
eurjchem-885	237	19	jung	jung	PROPN
eurjchem-885	237	20	,	,	PUNCT
eurjchem-885	237	21	j.	j.	PROPN
eurjchem-885	237	22	y.	y.	PROPN
eurjchem-885	237	23	;	;	PUNCT
eurjchem-885	237	24	park	park	PROPN
eurjchem-885	237	25	,	,	PUNCT
eurjchem-885	237	26	j.	j.	PROPN
eurjchem-885	237	27	w.	w.	PROPN
eurjchem-885	237	28	;	;	PUNCT
eurjchem-885	237	29	lee	lee	PROPN
eurjchem-885	237	30	,	,	PUNCT
eurjchem-885	237	31	k.	k.	PROPN
eurjchem-885	237	32	h.	h.	PROPN
eurjchem-885	237	33	drug	drug	PROPN
eurjchem-885	237	34	dev	dev	PROPN
eurjchem-885	237	35	.	.	PUNCT
eurjchem-885	238	1	ind	ind	PROPN
eurjchem-885	238	2	.	.	PUNCT
eurjchem-885	239	1	pharm	pharm	PROPN
eurjchem-885	239	2	.	.	PUNCT
eurjchem-885	240	1	2000	2000	NUM
eurjchem-885	240	2	,	,	PUNCT
eurjchem-885	240	3	26	26	NUM
eurjchem-885	240	4	,	,	PUNCT
eurjchem-885	240	5	27‐34	27‐34	NUM
eurjchem-885	240	6	.	.	PUNCT
eurjchem-885	241	1	[	[	X
eurjchem-885	241	2	9	9	NUM
eurjchem-885	241	3	]	]	PUNCT
eurjchem-885	241	4	.	.	PUNCT
eurjchem-885	242	1	alrawithi	alrawithi	PROPN
eurjchem-885	242	2	,	,	PUNCT
eurjchem-885	242	3	s.	s.	PROPN
eurjchem-885	242	4	;	;	PUNCT
eurjchem-885	242	5	hussein	hussein	PROPN
eurjchem-885	242	6	,	,	PUNCT
eurjchem-885	242	7	r.	r.	PROPN
eurjchem-885	242	8	;	;	PUNCT
eurjchem-885	242	9	al‐moshen	al‐moshen	PROPN
eurjchem-885	242	10	,	,	PUNCT
eurjchem-885	242	11	i.	i.	PROPN
eurjchem-885	242	12	;	;	PUNCT
eurjchem-885	242	13	raines	raines	PROPN
eurjchem-885	242	14	,	,	PUNCT
eurjchem-885	242	15	d.	d.	PROPN
eurjchem-885	242	16	ther	ther	PROPN
eurjchem-885	242	17	.	.	PUNCT
eurjchem-885	243	1	drug	drug	PROPN
eurjchem-885	243	2	monit	monit	PROPN
eurjchem-885	243	3	.	.	PUNCT
eurjchem-885	244	1	2001	2001	NUM
eurjchem-885	244	2	,	,	PUNCT
eurjchem-885	244	3	23	23	NUM
eurjchem-885	244	4	,	,	PUNCT
eurjchem-885	244	5	445‐448	445‐448	NUM
eurjchem-885	244	6	.	.	PUNCT
eurjchem-885	245	1	[	[	X
eurjchem-885	245	2	10	10	NUM
eurjchem-885	245	3	]	]	PUNCT
eurjchem-885	245	4	.	.	PUNCT
eurjchem-885	246	1	gordien	gordien	PROPN
eurjchem-885	246	2	,	,	PUNCT
eurjchem-885	246	3	j.	j.	PROPN
eurjchem-885	246	4	;	;	PUNCT
eurjchem-885	246	5	pigneux	pigneux	PROPN
eurjchem-885	246	6	,	,	PUNCT
eurjchem-885	246	7	a.	a.	NOUN
eurjchem-885	246	8	;	;	PUNCT
eurjchem-885	246	9	vigouroux	vigouroux	NUM
eurjchem-885	246	10	,	,	PUNCT
eurjchem-885	246	11	s.	s.	PROPN
eurjchem-885	246	12	;	;	PUNCT
eurjchem-885	246	13	tabrizi	tabrizi	NOUN
eurjchem-885	246	14	,	,	PUNCT
eurjchem-885	246	15	r.	r.	PROPN
eurjchem-885	246	16	;	;	PUNCT
eurjchem-885	246	17	accoceberry	accoceberry	PROPN
eurjchem-885	246	18	,	,	PUNCT
eurjchem-885	246	19	i.	i.	PROPN
eurjchem-885	246	20	j.	j.	PROPN
eurjchem-885	246	21	pharm	pharm	PROPN
eurjchem-885	246	22	.	.	PUNCT
eurjchem-885	246	23	biomed	biome	VERB
eurjchem-885	246	24	.	.	PUNCT
eurjchem-885	247	1	anal	anal	ADJ
eurjchem-885	247	2	.	.	PUNCT
eurjchem-885	248	1	2009	2009	NUM
eurjchem-885	248	2	,	,	PUNCT
eurjchem-885	248	3	50	50	NUM
eurjchem-885	248	4	,	,	PUNCT
eurjchem-885	248	5	932‐938	932‐938	NUM
eurjchem-885	248	6	.	.	PUNCT
eurjchem-885	249	1	[	[	X
eurjchem-885	249	2	11	11	NUM
eurjchem-885	249	3	]	]	PUNCT
eurjchem-885	249	4	.	.	PUNCT
eurjchem-885	250	1	jaruratanasirikul	jaruratanasirikul	PROPN
eurjchem-885	250	2	,	,	PUNCT
eurjchem-885	250	3	s.	s.	PROPN
eurjchem-885	250	4	;	;	PUNCT
eurjchem-885	250	5	sriwiriyajan	sriwiriyajan	NOUN
eurjchem-885	250	6	,	,	PUNCT
eurjchem-885	250	7	s.	s.	PROPN
eurjchem-885	250	8	eur	eur	PROPN
eurjchem-885	250	9	.	.	PUNCT
eurjchem-885	251	1	j.	j.	PROPN
eurjchem-885	251	2	clin	clin	PROPN
eurjchem-885	251	3	.	.	PUNCT
eurjchem-885	252	1	pharmacol	pharmacol	PROPN
eurjchem-885	252	2	.	.	PROPN
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eurjchem-885	253	2	,	,	PUNCT
eurjchem-885	253	3	63	63	NUM
eurjchem-885	253	4	,	,	PUNCT
eurjchem-885	253	5	451‐456	451‐456	NOUN
eurjchem-885	253	6	.	.	PUNCT
eurjchem-885	254	1	[	[	X
eurjchem-885	254	2	12	12	NUM
eurjchem-885	254	3	]	]	PUNCT
eurjchem-885	254	4	.	.	PUNCT
eurjchem-885	255	1	kumar	kumar	PROPN
eurjchem-885	255	2	,	,	PUNCT
eurjchem-885	255	3	v.	v.	PROPN
eurjchem-885	255	4	;	;	PUNCT
eurjchem-885	255	5	wang	wang	PROPN
eurjchem-885	255	6	,	,	PUNCT
eurjchem-885	255	7	l.	l.	PROPN
eurjchem-885	255	8	;	;	PUNCT
eurjchem-885	255	9	riebe	riebe	NOUN
eurjchem-885	255	10	,	,	PUNCT
eurjchem-885	255	11	m.	m.	NOUN
eurjchem-885	255	12	;	;	PUNCT
eurjchem-885	255	13	tung	tung	PROPN
eurjchem-885	255	14	,	,	PUNCT
eurjchem-885	255	15	h.	h.	PROPN
eurjchem-885	255	16	;	;	PUNCT
eurjchem-885	255	17	prud‐homme	prud‐homme	PROPN
eurjchem-885	255	18	,	,	PUNCT
eurjchem-885	255	19	r.	r.	PROPN
eurjchem-885	255	20	mol	mol	PROPN
eurjchem-885	255	21	.	.	PUNCT
eurjchem-885	255	22	pharm	pharm	PROPN
eurjchem-885	255	23	.	.	PUNCT
eurjchem-885	256	1	2009	2009	NUM
eurjchem-885	256	2	,	,	PUNCT
eurjchem-885	256	3	6	6	NUM
eurjchem-885	256	4	,	,	PUNCT
eurjchem-885	256	5	1118‐1124	1118‐1124	NUM
eurjchem-885	256	6	.	.	PUNCT
eurjchem-885	257	1	[	[	X
eurjchem-885	257	2	13	13	NUM
eurjchem-885	257	3	]	]	PUNCT
eurjchem-885	257	4	.	.	PUNCT
eurjchem-885	258	1	bharathi	bharathi	PROPN
eurjchem-885	258	2	,	,	PUNCT
eurjchem-885	258	3	v.	v.	ADP
eurjchem-885	258	4	;	;	PUNCT
eurjchem-885	258	5	hotha	hotha	NOUN
eurjchem-885	258	6	,	,	PUNCT
eurjchem-885	258	7	k.	k.	PROPN
eurjchem-885	258	8	;	;	PUNCT
eurjchem-885	258	9	sagar	sagar	PROPN
eurjchem-885	258	10	,	,	PUNCT
eurjchem-885	258	11	p.	p.	PROPN
eurjchem-885	258	12	v.	v.	PROPN
eurjchem-885	258	13	;	;	PUNCT
eurjchem-885	258	14	kumar	kumar	PROPN
eurjchem-885	258	15	,	,	PUNCT
eurjchem-885	258	16	s.	s.	PROPN
eurjchem-885	258	17	s.	s.	PROPN
eurjchem-885	258	18	;	;	PUNCT
eurjchem-885	258	19	reddy	reddy	PROPN
eurjchem-885	258	20	,	,	PUNCT
eurjchem-885	258	21	p.	p.	PROPN
eurjchem-885	258	22	r.	r.	PROPN
eurjchem-885	258	23	;	;	PUNCT
eurjchem-885	258	24	naidu	naidu	PROPN
eurjchem-885	258	25	,	,	PUNCT
eurjchem-885	258	26	a.	a.	PROPN
eurjchem-885	258	27	;	;	PUNCT
eurjchem-885	258	28	mullangi	mullangi	VERB
eurjchem-885	258	29	,	,	PUNCT
eurjchem-885	258	30	r.	r.	PROPN
eurjchem-885	258	31	j.	j.	PROPN
eurjchem-885	258	32	chromatogr	chromatogr	PROPN
eurjchem-885	258	33	.	.	PUNCT
eurjchem-885	259	1	b	b	PROPN
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eurjchem-885	259	3	,	,	PUNCT
eurjchem-885	259	4	868	868	NUM
eurjchem-885	259	5	,	,	PUNCT
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eurjchem-885	259	7	.	.	PUNCT
eurjchem-885	260	1	[	[	X
eurjchem-885	260	2	14	14	NUM
eurjchem-885	260	3	]	]	PUNCT
eurjchem-885	260	4	.	.	PUNCT
eurjchem-885	260	5	wook	wook	NOUN
eurjchem-885	260	6	choi	choi	NOUN
eurjchem-885	260	7	,	,	PUNCT
eurjchem-885	260	8	y.	y.	PROPN
eurjchem-885	260	9	;	;	PUNCT
eurjchem-885	260	10	nam	nam	PROPN
eurjchem-885	260	11	,	,	PUNCT
eurjchem-885	260	12	d.	d.	PROPN
eurjchem-885	260	13	;	;	PUNCT
eurjchem-885	260	14	kang	kang	PROPN
eurjchem-885	260	15	,	,	PUNCT
eurjchem-885	260	16	k.	k.	PROPN
eurjchem-885	260	17	h.	h.	PROPN
eurjchem-885	260	18	;	;	PUNCT
eurjchem-885	260	19	wook	wook	VERB
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eurjchem-885	260	21	,	,	PUNCT
eurjchem-885	260	22	k.	k.	PROPN
eurjchem-885	260	23	;	;	PUNCT
eurjchem-885	260	24	han	han	PROPN
eurjchem-885	260	25	,	,	PUNCT
eurjchem-885	260	26	i.	i.	PROPN
eurjchem-885	260	27	h.	h.	PROPN
eurjchem-885	260	28	;	;	PUNCT
eurjchem-885	260	29	chang	chang	PROPN
eurjchem-885	260	30	,	,	PUNCT
eurjchem-885	260	31	b.	b.	PROPN
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eurjchem-885	260	33	;	;	PUNCT
eurjchem-885	260	34	yoon	yoon	PROPN
eurjchem-885	260	35	,	,	PUNCT
eurjchem-885	260	36	m.	m.	NOUN
eurjchem-885	260	37	;	;	PUNCT
eurjchem-885	260	38	lee	lee	PROPN
eurjchem-885	260	39	,	,	PUNCT
eurjchem-885	260	40	j.	j.	PROPN
eurjchem-885	260	41	bull	bull	PROPN
eurjchem-885	260	42	.	.	PUNCT
eurjchem-885	261	1	korean	korean	ADJ
eurjchem-885	261	2	chem	chem	PROPN
eurjchem-885	261	3	.	.	PUNCT
eurjchem-885	262	1	soc	soc	PROPN
eurjchem-885	262	2	.	.	PUNCT
eurjchem-885	263	1	2006	2006	NUM
eurjchem-885	263	2	,	,	PUNCT
eurjchem-885	263	3	27	27	NUM
eurjchem-885	263	4	,	,	PUNCT
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eurjchem-885	263	6	.	.	PUNCT
eurjchem-885	264	1	[	[	X
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eurjchem-885	264	3	]	]	PUNCT
eurjchem-885	264	4	.	.	PUNCT
eurjchem-885	265	1	rhim	rhim	PROPN
eurjchem-885	265	2	,	,	PUNCT
eurjchem-885	265	3	s.	s.	PROPN
eurjchem-885	265	4	y.	y.	PROPN
eurjchem-885	265	5	;	;	PUNCT
eurjchem-885	265	6	park	park	PROPN
eurjchem-885	265	7	,	,	PUNCT
eurjchem-885	265	8	j.	j.	PROPN
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eurjchem-885	265	10	;	;	PUNCT
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eurjchem-885	265	12	,	,	PUNCT
eurjchem-885	265	13	y.	y.	PROPN
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eurjchem-885	265	15	;	;	PUNCT
eurjchem-885	265	16	kim	kim	PROPN
eurjchem-885	265	17	,	,	PUNCT
eurjchem-885	265	18	d.	d.	PROPN
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eurjchem-885	265	20	;	;	PUNCT
eurjchem-885	265	21	lee	lee	PROPN
eurjchem-885	265	22	,	,	PUNCT
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eurjchem-885	265	24	h	h	PROPN
eurjchem-885	265	25	;	;	PUNCT
eurjchem-885	265	26	shaw	shaw	PROPN
eurjchem-885	265	27	,	,	PUNCT
eurjchem-885	265	28	l.	l.	PROPN
eurjchem-885	265	29	m	m	PROPN
eurjchem-885	265	30	;	;	PUNCT
eurjchem-885	265	31	kang	kang	PROPN
eurjchem-885	265	32	,	,	PUNCT
eurjchem-885	265	33	j.	j.	PROPN
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eurjchem-885	265	37	,	,	PUNCT
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eurjchem-885	265	39	,	,	PUNCT
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eurjchem-885	265	41	.	.	PUNCT
eurjchem-885	266	1	[	[	X
eurjchem-885	266	2	16	16	NUM
eurjchem-885	266	3	]	]	PUNCT
eurjchem-885	266	4	.	.	PUNCT
eurjchem-885	267	1	yao	yao	PROPN
eurjchem-885	267	2	,	,	PUNCT
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eurjchem-885	267	4	;	;	PUNCT
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eurjchem-885	267	6	,	,	PUNCT
eurjchem-885	267	7	l.	l.	PROPN
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eurjchem-885	267	9	;	;	PUNCT
eurjchem-885	267	10	srinivas	srinivas	PROPN
eurjchem-885	267	11	,	,	PUNCT
eurjchem-885	267	12	n.	n.	PROPN
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eurjchem-885	267	16	.	.	PUNCT
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eurjchem-885	268	3	,	,	PUNCT
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eurjchem-885	268	5	,	,	PUNCT
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eurjchem-885	268	7	.	.	PUNCT
eurjchem-885	269	1	[	[	X
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eurjchem-885	269	3	]	]	PUNCT
eurjchem-885	269	4	.	.	PUNCT
eurjchem-885	270	1	castro‐puyana	castro‐puyana	PROPN
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eurjchem-885	270	6	,	,	PUNCT
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eurjchem-885	270	11	,	,	PUNCT
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eurjchem-885	270	13	l.	l.	PROPN
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eurjchem-885	270	16	,	,	PUNCT
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eurjchem-885	271	1	[	[	X
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eurjchem-885	271	3	]	]	PUNCT
eurjchem-885	271	4	.	.	PUNCT
eurjchem-885	272	1	breadmore	breadmore	PROPN
eurjchem-885	272	2	,	,	PUNCT
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eurjchem-885	272	4	;	;	PUNCT
eurjchem-885	272	5	prochazkova	prochazkova	X
eurjchem-885	272	6	,	,	PUNCT
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eurjchem-885	272	8	;	;	PUNCT
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eurjchem-885	272	10	,	,	PUNCT
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eurjchem-885	272	12	;	;	PUNCT
eurjchem-885	272	13	thormann	thormann	PROPN
eurjchem-885	272	14	,	,	PUNCT
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eurjchem-885	272	18	.	.	PUNCT
eurjchem-885	273	1	a	a	DET
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eurjchem-885	273	3	,	,	PUNCT
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eurjchem-885	273	5	,	,	PUNCT
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eurjchem-885	273	7	.	.	PUNCT
eurjchem-885	274	1	[	[	X
eurjchem-885	274	2	19	19	NUM
eurjchem-885	274	3	]	]	PUNCT
eurjchem-885	274	4	.	.	PUNCT
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eurjchem-885	275	2	,	,	PUNCT
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eurjchem-885	275	5	;	;	PUNCT
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eurjchem-885	275	7	,	,	PUNCT
eurjchem-885	275	8	f.	f.	PROPN
eurjchem-885	275	9	;	;	PUNCT
eurjchem-885	275	10	thormann	thormann	PROPN
eurjchem-885	275	11	,	,	PUNCT
eurjchem-885	275	12	w.	w.	PROPN
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eurjchem-885	275	14	.	.	PUNCT
eurjchem-885	276	1	chem	chem	PROPN
eurjchem-885	276	2	.	.	PUNCT
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eurjchem-885	277	2	,	,	PUNCT
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eurjchem-885	277	4	,	,	PUNCT
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eurjchem-885	277	6	.	.	PUNCT
eurjchem-885	278	1	[	[	X
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eurjchem-885	278	4	.	.	PUNCT
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eurjchem-885	279	2	,	,	PUNCT
eurjchem-885	279	3	a.	a.	PROPN
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eurjchem-885	279	5	;	;	PUNCT
eurjchem-885	279	6	gomez	gomez	PROPN
eurjchem-885	279	7	,	,	PUNCT
eurjchem-885	279	8	j.	j.	PROPN
eurjchem-885	279	9	;	;	PUNCT
eurjchem-885	279	10	marina	marina	PROPN
eurjchem-885	279	11	,	,	PUNCT
eurjchem-885	279	12	m.	m.	PROPN
eurjchem-885	279	13	l.	l.	PROPN
eurjchem-885	279	14	;	;	PUNCT
eurjchem-885	279	15	lavandera	lavandera	PROPN
eurjchem-885	279	16	,	,	PUNCT
eurjchem-885	279	17	j.	j.	PROPN
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eurjchem-885	279	21	,	,	PUNCT
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eurjchem-885	279	23	,	,	PUNCT
eurjchem-885	279	24	2503‐2511	2503‐2511	NUM
eurjchem-885	279	25	.	.	PUNCT
eurjchem-885	280	1	[	[	X
eurjchem-885	280	2	21	21	NUM
eurjchem-885	280	3	]	]	PUNCT
eurjchem-885	280	4	.	.	PUNCT
eurjchem-885	281	1	radoslaw	radoslaw	PROPN
eurjchem-885	281	2	,	,	PUNCT
eurjchem-885	281	3	j.	j.	PROPN
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eurjchem-885	281	5	;	;	PUNCT
eurjchem-885	281	6	krzek	krzek	PROPN
eurjchem-885	281	7	,	,	PUNCT
eurjchem-885	281	8	j.	j.	PROPN
eurjchem-885	281	9	acta	acta	PROPN
eurjchem-885	281	10	pol	pol	PROPN
eurjchem-885	281	11	.	.	PUNCT
eurjchem-885	282	1	pharm	pharm	PROPN
eurjchem-885	282	2	.	.	PUNCT
eurjchem-885	283	1	2009	2009	NUM
eurjchem-885	283	2	,	,	PUNCT
eurjchem-885	283	3	66	66	NUM
eurjchem-885	283	4	,	,	PUNCT
eurjchem-885	283	5	19‐23	19‐23	NUM
eurjchem-885	283	6	.	.	PUNCT
eurjchem-885	284	1	[	[	X
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eurjchem-885	284	3	]	]	PUNCT
eurjchem-885	284	4	.	.	PUNCT
eurjchem-885	284	5	el‐enany	el‐enany	PROPN
eurjchem-885	284	6	,	,	PUNCT
eurjchem-885	284	7	n.	n.	NOUN
eurjchem-885	284	8	;	;	PUNCT
eurjchem-885	284	9	el‐sherbiny	el‐sherbiny	ADJ
eurjchem-885	284	10	,	,	PUNCT
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eurjchem-885	284	12	;	;	PUNCT
eurjchem-885	284	13	belal	belal	PROPN
eurjchem-885	284	14	,	,	PUNCT
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eurjchem-885	284	18	.	.	PROPN
eurjchem-885	285	1	chem	chem	PROPN
eurjchem-885	285	2	.	.	PUNCT
eurjchem-885	286	1	soc	soc	PROPN
eurjchem-885	286	2	.	.	PUNCT
eurjchem-885	287	1	2007	2007	NUM
eurjchem-885	287	2	,	,	PUNCT
eurjchem-885	287	3	54	54	NUM
eurjchem-885	287	4	,	,	PUNCT
eurjchem-885	287	5	375‐	375‐	NUM
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eurjchem-885	287	7	.	.	PUNCT
eurjchem-885	288	1	[	[	X
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eurjchem-885	288	3	]	]	PUNCT
eurjchem-885	288	4	.	.	PUNCT
eurjchem-885	289	1	armstrong	armstrong	PROPN
eurjchem-885	289	2	,	,	PUNCT
eurjchem-885	289	3	d.	d.	PROPN
eurjchem-885	289	4	;	;	PUNCT
eurjchem-885	289	5	henry	henry	PROPN
eurjchem-885	289	6	,	,	PUNCT
eurjchem-885	289	7	s.	s.	PROPN
eurjchem-885	289	8	j.	j.	PROPN
eurjchem-885	289	9	liq	liq	PROPN
eurjchem-885	289	10	.	.	PUNCT
eurjchem-885	290	1	chromatogr	chromatogr	PROPN
eurjchem-885	290	2	.	.	PUNCT
eurjchem-885	291	1	r.	r.	PROPN
eurjchem-885	291	2	t.	t.	PROPN
eurjchem-885	291	3	1980	1980	NUM
eurjchem-885	291	4	,	,	PUNCT
eurjchem-885	291	5	3	3	NUM
eurjchem-885	291	6	,	,	PUNCT
eurjchem-885	291	7	657‐662	657‐662	NUM
eurjchem-885	291	8	.	.	PUNCT
eurjchem-885	292	1	[	[	X
eurjchem-885	292	2	24	24	NUM
eurjchem-885	292	3	]	]	PUNCT
eurjchem-885	292	4	.	.	PUNCT
eurjchem-885	292	5	berthod	berthod	PROPN
eurjchem-885	292	6	,	,	PUNCT
eurjchem-885	292	7	a.	a.	PROPN
eurjchem-885	292	8	j.	j.	PROPN
eurjchem-885	292	9	chromatogr	chromatogr	PROPN
eurjchem-885	292	10	.	.	PUNCT
eurjchem-885	293	1	a	a	DET
eurjchem-885	293	2	1997	1997	NUM
eurjchem-885	293	3	,	,	PUNCT
eurjchem-885	293	4	780	780	NUM
eurjchem-885	293	5	,	,	PUNCT
eurjchem-885	293	6	191‐206	191‐206	NUM
eurjchem-885	293	7	.	.	PUNCT
eurjchem-885	294	1	[	[	X
eurjchem-885	294	2	25	25	NUM
eurjchem-885	294	3	]	]	PUNCT
eurjchem-885	294	4	.	.	PUNCT
eurjchem-885	295	1	validation	validation	NOUN
eurjchem-885	295	2	of	of	ADP
eurjchem-885	295	3	analytical	analytical	ADJ
eurjchem-885	295	4	procedure	procedure	NOUN
eurjchem-885	295	5	:	:	PUNCT
eurjchem-885	295	6	text	text	NOUN
eurjchem-885	295	7	and	and	CCONJ
eurjchem-885	295	8	methodology	methodology	NOUN
eurjchem-885	295	9	.	.	PUNCT
eurjchem-885	296	1	international	international	ADJ
eurjchem-885	296	2	conference	conference	NOUN
eurjchem-885	296	3	on	on	ADP
eurjchem-885	296	4	harmonization	harmonization	NOUN
eurjchem-885	296	5	q2(r1	q2(r1	NOUN
eurjchem-885	296	6	)	)	PUNCT
eurjchem-885	296	7	,	,	PUNCT
eurjchem-885	296	8	2005	2005	NUM
eurjchem-885	296	9	.	.	PUNCT
eurjchem-885	296	10	accessed	access	VERB
eurjchem-885	296	11	at	at	ADP
eurjchem-885	296	12	:	:	PUNCT
eurjchem-885	296	13	http://www.bioforum.org.il/uploads/editor/karen/q2_r1_step4.pdf	http://www.bioforum.org.il/uploads/editor/karen/q2_r1_step4.pdf	NOUN
eurjchem-885	297	1	[	[	X
eurjchem-885	297	2	26	26	NUM
eurjchem-885	297	3	]	]	PUNCT
eurjchem-885	297	4	.	.	PUNCT
eurjchem-885	298	1	miller	miller	PROPN
eurjchem-885	298	2	,	,	PUNCT
eurjchem-885	298	3	j.	j.	PROPN
eurjchem-885	298	4	c.	c.	PROPN
eurjchem-885	298	5	;	;	PUNCT
eurjchem-885	298	6	miller	miller	PROPN
eurjchem-885	298	7	,	,	PUNCT
eurjchem-885	298	8	j.	j.	PROPN
eurjchem-885	298	9	n.	n.	PROPN
eurjchem-885	298	10	statistics	statistics	PROPN
eurjchem-885	298	11	and	and	CCONJ
eurjchem-885	298	12	chemometrics	chemometric	NOUN
eurjchem-885	298	13	for	for	ADP
eurjchem-885	298	14	analytical	analytical	ADJ
eurjchem-885	298	15	chemistry	chemistry	NOUN
eurjchem-885	298	16	,	,	PUNCT
eurjchem-885	298	17	5th	5th	ADJ
eurjchem-885	298	18	edition	edition	NOUN
eurjchem-885	298	19	.	.	PUNCT
eurjchem-885	299	1	pearson	pearson	PROPN
eurjchem-885	299	2	education	education	PROPN
eurjchem-885	299	3	limited	limit	VERB
eurjchem-885	299	4	:	:	PUNCT
eurjchem-885	299	5	harlow	harlow	PROPN
eurjchem-885	299	6	,	,	PUNCT
eurjchem-885	299	7	england	england	PROPN
eurjchem-885	299	8	,	,	PUNCT
eurjchem-885	299	9	2005	2005	NUM
eurjchem-885	299	10	,	,	PUNCT
eurjchem-885	299	11	pp	pp	ADJ
eurjchem-885	299	12	.	.	PUNCT
eurjchem-885	300	1	39‐73	39‐73	NUM
eurjchem-885	300	2	,	,	PUNCT
eurjchem-885	300	3	107‐149	107‐149	NUM
eurjchem-885	300	4	,	,	PUNCT
eurjchem-885	300	5	256	256	NUM
eurjchem-885	300	6	.	.	PUNCT
eurjchem-885	301	1	[	[	X
eurjchem-885	301	2	27	27	NUM
eurjchem-885	301	3	]	]	PUNCT
eurjchem-885	301	4	.	.	PUNCT
eurjchem-885	302	1	the	the	DET
eurjchem-885	302	2	united	united	PROPN
eurjchem-885	302	3	states	states	PROPN
eurjchem-885	302	4	pharmacopeia	pharmacopeia	PROPN
eurjchem-885	302	5	,	,	PUNCT
eurjchem-885	302	6	30th	30th	NOUN
eurjchem-885	302	7	rev	rev	X
eurjchem-885	302	8	.	.	PROPN
eurjchem-885	302	9	,	,	PUNCT
eurjchem-885	302	10	and	and	CCONJ
eurjchem-885	302	11	the	the	DET
eurjchem-885	302	12	national	national	ADJ
eurjchem-885	302	13	formulary	formulary	PROPN
eurjchem-885	302	14	25th	25th	PROPN
eurjchem-885	302	15	ed	ed	NOUN
eurjchem-885	302	16	.	.	PUNCT
eurjchem-885	303	1	rockville	rockville	PROPN
eurjchem-885	303	2	,	,	PUNCT
eurjchem-885	303	3	md	md	PROPN
eurjchem-885	303	4	:	:	PUNCT
eurjchem-885	303	5	the	the	DET
eurjchem-885	303	6	united	united	PROPN
eurjchem-885	303	7	states	states	PROPN
eurjchem-885	303	8	pharmacopeial	pharmacopeial	ADJ
eurjchem-885	303	9	convention	convention	NOUN
eurjchem-885	303	10	,	,	PUNCT
eurjchem-885	303	11	2007	2007	NUM
eurjchem-885	303	12	.	.	PUNCT