EUROPEAN JOURNAL OF PURE AND APPLIED MATHEMATICS Vol. 10, No. 3, 2017, 419-439 ISSN 1307-5543 – www.ejpam.com Published by New York Business Global Weighted Opial–type inequalities for fractional integral and differential operators involving generalized Mittag–Leffler functions Zivord Tomovski1,2 Josip Pečarić3, Ghulam Farid4,∗ 1 Department of Mathematics, University of Rijeka, Croatia 2 Institute of Mathematics, Faculty of Natural Sciences and Mathematics,St. Cyril and Methodius University, Skopje, Republic of Macedonia 3 Faculty of Textile Technology, University of Zagreb, Croatia 4 Department of Mathematics, COMSATS Institute of Information Technology, Attock Campus, Pakistan Abstract. In this paper, by using Hölder integral inequality we give generalization of wighted Opial–type inequalities by using generalized fractional integral and differential operators involving generalized Mittag–Leffler functions. 2010 Mathematics Subject Classifications: 26A33, 26D15, 33E12 Key Words and Phrases: Opial–type inequality, fractional integral, fractional derivative, Mittag– Leffler function 1. Introduction and preliminaries In 1960 Opial established the following integral inequality [17]. Let x(t) ∈ C(1)[0, h] be such that x(0) = x(h) = 0, and x(t) > 0 in (0, h). Then ∫ h 0 |x(t)x′(t)|dt ≤ h 4 ∫ h 0 ( x′(t) )2 dt, (1) where constant h 4 is the best possible. Opial’s inequality [3, 4, 5, 6, 7, 14] is studied extensively by many researchers. It recognizes as a fundamental result in the theory of differential and difference equations and other areas of mathematics, and has attracted a great deal of attention in the literature ∗Corresponding author. Email addresses: zivorad.tomovski@math.uniri.hr, zivoradt@yahoo.com (Z. Tomovski), pecaric@element.hr (J. Pečarić), faridphdsms@hotmail.com, ghlmfarid@ciit-attock.edu.pk (G. Farid) http://www.ejpam.com 419 c© 2017 EJPAM All rights reserved. Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 420 (see, for instance, [1, 2]). In [3, 4, 5, 6, 7] Opial–type integral inequalities were considered for different kinds of fractional derivative and fractional integral operators for example Riemann-Liouville, Caputo, Canvati etc were established. Our paper is motivated by the work of Koliha and Pecaric [14] on Opial inequalities for fractional differential operators and presents a class of very general weighted Opial type inequalities using integral and differential operators in fractional calculus involving generalized Mittag-Leffler functions. The following hypotheses are assumed throughout this section: Let I be a closed interval in R, a is a fixed point in I, let Φ be a continuous function nonnegative on I × I, and let y, h ∈ C (I) . We assume that the following condition involving Φ, h and y is satisfied: |y (x)| ≤ ∣∣∣∣∣∣ x∫ a Φ (x, t) |h (t)| dt ∣∣∣∣∣∣ , x ∈ I. (2) Koliha and Pecaric in [14] proved the following weighted Opial type inequalities by application of Hölder integral inequality. Theorem 1. Assume that (2) holds. Let x ∈ I, let α, β > 0, r > max (1, α) , and let U, V ∈ C (I) be such that U (s) ≥ 0 and V (s) > 0 for all s ∈ I. Then∣∣∣∣∣∣ x∫ a U (s) |y (s)|β |h (s)|α ds ∣∣∣∣∣∣ ≤ C (x) ∣∣∣∣∣∣ x∫ a V (s) |h (s)|r ds ∣∣∣∣∣∣ (α+β)/r (3) where C (x) = ( α α+ β )α/r x∫ a ( U r (s)V −α (s) )1/(r−α) P (s)β(r−1)/(r−α) ds (r−α)/r , (4) P (s) = ∣∣∣∣∣∣ s∫ a V (t)−1/(r−1) Φ (s, t)r/(r−1) dt ∣∣∣∣∣∣ . (5) Theorem 2. Assume that (2) holds. Let x ∈ I, α, β > 0, r > max (1, α) , and let U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I.Then ∣∣∣∣∣∣ x∫ a U (s) |y (s)|β |h (s)|α ds ∣∣∣∣∣∣ ≤ x∫ a U (ω) ∣∣∣∣∣∣ ω∫ a V (t) Φ (ω, t) dt ∣∣∣∣∣∣ r−α r dω ‖V ‖β∞ ‖h‖ α+β ∞ . (6) If the exponents α, β and r in Theorem 2 are not necessarily positive, in this case the inequality (2) must be strengthened to equality Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 421 |y (s)| = ∣∣∣∣∣∣ s∫ a Φ (s, t) |h (t)| dt ∣∣∣∣∣∣ , s ∈ I, (7) where Φ is a nonnegative continuous function on I × I, and y, h ∈ C (I) . Theorem 3. Assume that (7) holds. Let x ∈ I, U, V ∈ C (I) be such that U (s) ≥ 0 and V (s) > 0 for all s ∈ I. Consider real numbers α, β, r and the following relations: (i) r > 1, β > 0, 0 < α < r; (ii) r < α < 0, β < 0; (iii) −α < β < 0, 0 < α < r < 1; (iv) β > 0, 0 < r < min (α, 1) ; (v) α < 0 < r < 1, 0 < β < −α; (vi) β < 0, α < 0, r > 1; (vii) 1 < r < α, −α < β < 0; (viii) β > 0, r < 0 < α; (ix) α < r < 0, 0 < β < −α. If one of the conditions (i)-(iii) is satisfied, then∣∣∣∣∣∣ x∫ a U (s) |y (s)|β |h (s)|α ds ∣∣∣∣∣∣ ≤ C (x) ∣∣∣∣∣∣ x∫ a V (s) |h (s)|r ds ∣∣∣∣∣∣ (α+β)/r . (8) If one of the conditions (iv)-(ix) is satisfied, then ∣∣∣∣∣∣ x∫ a U (s) |y (s)|β |h (s)|α ds ∣∣∣∣∣∣ ≥ C (x) ∣∣∣∣∣∣ x∫ a V (s) |h (s)|r ds ∣∣∣∣∣∣ (α+β)/r , (9) where C(x) is defined by (4) and (5). 2. Fractional differential and integral operators involving Mittag-Leffler functions Fractional calculus refers to integration and differentiation of fractional order. Several mathematicians contributed to this subject over the years. People like Liouville, Riemann, and Weyl made major contributions to the theory of fractional calculus. The story on the fractional calculus continued with contributions from Fourier, Abel, Lacroix, Leibniz, Grunwald and Letnikov. For a historical survey the reader may see [12, 15, 16]. Fractional integral inequalities are useful in establishing the uniqueness of solutions for certain fractional partial differential equations. They also provide upper and lower bounds for the solutions of fractional boundary value problems. These considerations have led various researchers in the field of integral inequalities to explore certain extensions and generalizations by involving fractional calculus operators (see, [9, 11, 18, 20, 21] ). Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 422 Let x > 0. By L1 (0, x) we denote the space of all Lebesgue integrable functions on the interval (0, x) . For any f ∈ L1 (0, x) the Riemann-Liouvill fractional integral of f of order ν is defined by( Iνa+f ) (s) = 1 Γ(ν) ∫ s a (x− t)ν−1f(t)dt = (f ∗Kν) (s) , s ∈ [0, x] , ν > 0, (10) where Kν (s) = sν−1 Γ(ν) . The integral on the right side of (10) exists for almost s ∈ [0, x] and Iνa+f ∈ L1 (0, x) .The Riemann-Liouville fractional derivative of f ∈ L1 (0, x) of order ν is defined by ( Dν a+f ) (x) = ( d dx )n ( In−νa+ f ) (x) , (ν > 0, n = [ν] + 1) (11) By Cm [0, x] we denote the space of all functions which have continuous derivatives up to order m, and AC [0, x] is the space of all absolutely continuous functions on [0, x] . By ACm [0, x] we denote the space of all functions f ∈ Cm [0, x] with f (m−1) ∈ AC [0, x] . By L∞ (0, x) we denote the space of all measurable functions essentially bounden on [0, x] . Let µ > 0, m = [µ] + 1, f ∈ ACm [a, b] . The Caputo derivative of order µ > 0 is defined as( CDµ a+f ) (x) = ( Im−µa+ dm dxm f ) (x) (12) = 1 Γ (m− µ) x∫ a (x− s)m−µ−1 dm dsm f (s) ds. Definition 1. [21] Let f ∈ L1 [a, b] , f ∗K(1−ν)(1−µ) ∈ AC1 [a, b] . The fractional derivative operator Dµ,ν a+ of order 0 < µ < 1 and type 0 ≤ ν ≤ 1 with respect to x ∈ [a, b] is defined by ( Dµ,ν a+ f ) (x) = ( I ν(1−µ) a+ d dx ( I (1−ν)(1−µ) a+ f )) (x) (13) whenever the right hand side exists. This generalization gives the classical Riemann-Liouville fractional differentiation op- erator if ν = 0. For ν = 1 it gives the fractional differential operator introduced by Caputo. We denote it by Dµ,1 a+f =C Dµ a+f. Several authors (see, [9, 20]) called (13) the Hilfer fractional derivative. Applications of Dµ,ν a+ are given in [9, 20, 21, 23]. The purpose of this paper is to give weighted Opial type integral inequalities involving different kinds of fractional differential operators. For 0 < µ < 1 and 0 < ν ≤ 1, the Hilfer fractional differentiation operator Dµ,ν a+ can be rewritten in the form( Dµ,ν a+ f ) (x) = ( I ν(1−µ) a+ ( Dµ+ν−µν a+ f )) (x) (14) = 1 Γ (ν (1− µ)) x∫ a+ (x− τ)ν(1−µ)−1 ( Dµ+ν−µν a+ f ) (τ) dτ. Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 423 Definition of this generalized fractional integral operator containing Mittag–Leffler func- tion is as follows. Definition 2. (Prabhakar [18]) Let µ, ν, γ be positive real numbers and ω ∈ R. Then the generalized fractional integral operator εγµ,ν,ω,a+ for a real-valued continuous function f is defined by: (εγµ,ν,ω,a+f)(x) = x∫ a+ (x− t)ν−1Eγµ,ν(ω(x− t)µ)f(t)dt, (15) where the function Eγµ,ν is generalized Mittag–Leffler function defined as Eγµ,ν(t) = ∞∑ n=0 (γ)n n!Γ(µn+ ν) tn, (16) and (γ)n is the Pochhammer symbol: (γ)n = γ(γ + 1)...(γ + n− 1), (γ)0 = 1. The integral operaor εγ µ,ν,ω,a+ is bounded in the space C(I) with a finite norm ‖f‖C = max x∈I |f (x)| , and there exists a positive constant M > 0, such that (see [11]) ∥∥∥εγµ,ν,ω,a+f∥∥∥C ≤M ‖f‖C . For ω = 0 in (15), integral operator εγ µ,ν,ω,a+ would correspond essentially to the Riemann-Liouville fractional integral operator Iνa+f . Let eγµ,ν (t, ω) = tν−1Eγµ,ν (−ωtµ). In [22] Tomovski et al. proved the following uniform estimate for the function eγµ,ν (ω, t) : Lemma 1. If µ ∈ (0, 1) , γ, ω > 0, µγ > ν − 1 > 0, then the following uniform bound holds true ∣∣eγµ,ν (t, ω) ∣∣ ≤ Γ ( γ − ν−1 µ ) Γ ( ν−1 µ ) πµω ν−1 µ Γ (γ) [ cos (πµ 2 )]γ− ν−1 µ , t > 0. (17) Lemma 2. [22] If µ ∈ (0, 1) , γ, ω > 0, ν ≥ µγ, then eγµ,ν (t, ω) > 0, for all t > 0. We define a variant of Sobolev space: Wm,1 [a, b] = { f ∈ L1 [a, b] : dm dtm f ∈ L1 [a, b] } . (18) Definition 3. (Prabhakar derivative [9]) Let f ∈ L1 [0, b] , 0 < t < b ≤ ∞, µ, ν, γ > 0, and f ∗ e−γµ,m−ν,ω ∈Wm,1 [0, b] , m = [ν]. Then the Prabhakar derivative is defined by following relation ( Dγ µ,ν,ω,0+f ) (t) = dm dtm ε−γµ,m−ν,ω,0+f (t) . (19) Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 424 Definition 4. (Caputo-Prabhakar derivative [9]) Let f ∈ L1 [0, b] , 0 < t < b ≤ ∞, µ, ν, γ > 0 , m = [ν]. Then the Caputo-Prabhakar derivative for f ∈ ACm [0, b] is defined by following relation ( CDγ µ,ν,ω,0+f ) (t) = ε−γµ,m−ν,ω,0+ dm dtm f (t) (20) = ( Dγ µ,ν,ω,0+f ) (t)− m−1∑ k=0 tk−µE−γµ,k−ν+1 (ωtµ) f (k) (0+) . Remark 1. Let µ, ν, γ > 0 and f ∈ ACm [0, b] , 0 < t < b ≤ ∞, then ( CDγ µ,ν,ω,0+f ) (t) = Dγ µ,ν,ω,0+ ( f (t)− m−1∑ k=0 tk k! f (k) (0+) ) . (21) Moreover, if f (k) (0+) = 0, k = 0, 1, 2, ...m− 1, then( CDγ µ,ν,ω,0+f ) (t) = ( Dγ µ,ν,ω,0+f ) (t) . Definition 5. (Hilfer-Prabhakar derivative [9]). Let µ ∈ (0, 1) , ν ∈ [0, 1] , and let f ∈ L1 [a, b] , 0 < t < b ≤ ∞, f ∗ e−γ(1−ν) ρ, (1−ν)(1−µ), ω ∈ AC 1 [0, b] . The Hilfer-Prabhakar derivative is defined by( Dγ, µ, ν ρ, ω, 0+f ) (t) = ( ε−γνρ, ν(1−µ), ω, 0+ d dt ( ε −γ(1−ν) ρ, (1−ν)(1−µ), ω, 0+f )) (t) , (22) where γ, ω ∈ R, ρ > 0, and ε0ρ, 0, ω, 0+f = f. Moreover,( Dγ, µ ρ, ω, 0+f ) (t) = ( Dγ, µ, 1 ρ, ω, 0+f ) (t) = ( ε−γρ, 1−µ, ω, 0+ d dt f ) (t) . (23) 3. Main Results Our first main result is given in the following theorem. Namely, we present Opial type inequalities for Hilfer fractional operator (13). Theorem 4. Let x > 0, α, β > 0, µ ∈ (0, 1) , ν ∈ (0, 1] and U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I. Then let f ∈ L (0, x) have an integrable fractional derivative Dµ+ν−µν 0+ f ∈ L∞ (0, x) . (i) If r > max { 1, α, (ν (1− µ))−1 } , then x∫ 0 U (s) ∣∣(Dµ,ν 0+ f ) (s) ∣∣β ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣α ds ≤ Ω (x)× Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 425 x∫ 0 V (s) ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣r ds  α+β r , (24) where Ω (x) = ( α α+ β )α r  x∫ 0 ( U r (s)V −α (s) ) 1 r−α (∆ (s)) β(r−1) r−α ds  r−α r , (25) ∆ (s) = s∫ 0 (V (t))− 1 r−1 [ 1 Γ (ν (1− µ)) (s− t)ν(1−µ)−1 ] r r−1 dt. (26) (ii) If 0 < r < min { α, 1, (ν (1− µ))−1 } , then x∫ 0 U (s) ∣∣(Dµ,ν 0+ f ) (s) ∣∣β ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣α ds ≥ Ω (x)×  x∫ 0 V (s) ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣r ds  α+β r , (27) where Ω (x) and ∆ (s) are given by (25) and (26). Proof. According to (14), ( Dµ,ν 0+ f ) (s) = 1 Γ (ν (1− µ)) s∫ 0 (s− τ)ν(1−µ)−1 ( Dµ+ν−µν 0+ f ) (τ) dτ, s ∈ [0, x] . (28) Setting y (s) = ( Dµ,ν 0+ f ) (s) , h (s) = ( Dµ+ν−µν 0+ f ) (s) , Φ (s, t) = (s− t)ν(1−µ)−1 Γ (ν (1− µ)) , we observe that condition (2) is satisfied with a = 0 and I = [0, x] : |y (s)| ≤ s∫ 0 Φ (s, t) |h (t)| dt, 0 ≤ s ≤ x. The rest of the proof of (i) is the same as Theorem 4.2 of [14]. For ν = 1, we obtain the following Opial type inequalities for Caputo fractional deriva- tive, defined by (12). Corollary 1. Let x > 0, α, β > 0, µ ∈ (0, 1) and U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I and let f ∈ AC1 (0, x) . Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 426 (i) If r > max { 1, α, (1− µ)−1 } , then x∫ 0 U (s) ∣∣(CDµ 0+f ) (s) ∣∣β ∣∣∣∣ ddsf (s) ∣∣∣∣α ds ≤ Ω (x)  x∫ 0 V (s) ∣∣∣∣ ddsf (s) ∣∣∣∣r ds  α+β r , (29) where Ω (x) = ( α α+ β )α r  x∫ 0 ( U r (s)V −α (s) ) 1 r−α (∆ (s)) β(r−1) r−α ds  r−α r , (30) ∆ (s) = s∫ 0 (V (t))− 1 r−1 [ 1 Γ (1− µ) (s− t)µ ] r r−1 dt. (31) (ii) If 0 < r < min { α, 1, (1− µ)−1 } , then x∫ 0 U (s) ∣∣(CDµ 0+f ) (s) ∣∣β ∣∣∣∣ ddsf (s) ∣∣∣∣α ds ≥ Ω (x)  x∫ 0 V (s) ∣∣∣∣ ddsf (s) ∣∣∣∣r ds  α+β r , (32) where Ω (x) and ∆ (s) are given by (30) and (31). Corollary 2. Let x > 0, α, β > 0, µ ∈ (0, 1) , ν ∈ (0, 1] and let f ∈ L (0, x) have an integrable fractional derivative Dµ+ν−µν 0+ f ∈ L∞ (0, x) . (i) If r > max { 1, α, (ν (1− µ))−1 } , then x∫ 0 ∣∣(Dµ,ν 0+ f ) (s) ∣∣β ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣α ds ≤ Ω1x βν(1−µ)−α+1 r +1×  x∫ 0 ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣r ds  α+β r , (33) where Ω1 = ( α α+β )α r (Γ (ν (1− µ)))−β ( r−1 ν(1−µ)r−1 )β(r−1) r [ β[ν(1−µ)r−1] r−α + 1 ] r−α r . (34) (ii) If 0 < r < min { α, 1, (ν (1− µ))−1 } , then Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 427 x∫ 0 ∣∣(Dµ,ν 0+ f ) (s) ∣∣β ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣α ds ≥ Ω1x βν(1−µ)−α+1 r +1×  x∫ 0 ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣r ds  α+β r , (35) where Γ is the Euler Gamma function and Ω1 is given by (34). Proof. By Theorem 4, x∫ 0 ∣∣(Dµ,ν 0+ f ) (s) ∣∣β ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣α ds ≤ Ω (x)  x∫ 0 ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣r ds  α+β r , (36) where Ω (x) = ( α α+ β )α r  x∫ 0  s∫ 0 [ (s− t)ν(1−µ)−1 Γ (ν (1− µ)) ] r r−1 dt  β(r−1) r−α ds  r−α r = ( α α+ β )α r (Γ (ν (1− µ)))−β ( r − 1 ν (1− µ) r − 1 )β(r−1) r  x∫ 0 s β[ν(1−µ)r−1] r−α ds  r−α r = ( α α+β )α r (Γ (ν (1− µ)))−β ( r−1 ν(1−µ)r−1 )β(r−1) r [ β[ν(1−µ)r−1] r−α + 1 ] r−α r xβν(1−µ)−α+1 r +1. Corollary 3. Let x > 0, α, β > 0, p > q > 0, µ ∈ (0, 1) , ν ∈ (0, 1]. Then let f ∈ L (0, x) have an integrable fractional derivative Dµ+ν−µν 0+ f ∈ L∞ (0, x) . (i) If r > max { 1, α, 1 + q, (ν (1− µ))−1 } , then x∫ 0 sp ∣∣(Dµ,ν 0+ f ) (s) ∣∣β ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣α ds ≤ Ω2x βν(1−µ)+p− (β+α)(q+1) r +1 (37) ×  x∫ 0 sq ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣r ds  α+β r , where Ω2 = ( α α+β )α r (Γ (ν (1− µ)))−β ( B ( r−1−q r−1 , ν(1−µ)r−1 r−1 ))β(r−1) r [ β[ν(1−µ)r−1−q]+pr−qα r−α + 1 ] r−α r . (38) Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 428 (ii) If 0 < r < min { α, 1, 1 + q, (ν (1− µ))−1 } , then x∫ 0 sp ∣∣(Dµ,ν 0+ f ) (s) ∣∣β ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣α ds ≥ Ω2x βν(1−µ)+p− (α+β)(q+1) r +1 (39) ×  x∫ 0 sq ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣r ds  α+β r , where Γ and B are the Euler Gamma and Beta functions and Ω2 is given by (38). Proof. By Theorem 4, x∫ 0 sp ∣∣(Dµ,ν 0+ f ) (s) ∣∣β ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣α ds ≤ Ω (x)  x∫ 0 sq ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣r ds  α+β r , (40) where Ω (x) = ( α α+ β )α r ×  x∫ 0 s pr−qα r−α  s∫ 0 (tq)− 1 r−1 [ (s− t)ν(1−µ)−1 Γ (ν (1− µ)) ] r r−1 dt  β(r−1) r−α ds  r−α r = ( α α+ β )α r (Γ (ν (1− µ)))−β ×  x∫ 0 s pr−qα r−α  s∫ 0 t r−1−q r−1 −1 (s− t) ν(1−µ)r−1 r−1 −1 dt  β(r−1) r−α ds  r−α r = ( α α+ β )α r (Γ (ν (1− µ)))−β ( B ( r − 1− q r − 1 , ν (1− µ) r − 1 r − 1 ))β(r−1) r ×  x∫ 0 s β[ν(1−µ)r−1−q]+pr−qα r−α ds  r−α r = ( α α+β )α r (Γ (ν (1− µ)))−β ( B ( r−1−q r−1 , ν(1−µ)r−1 r−1 ))β(r−1) r [ β[ν(1−µ)r−1−q]+pr−qα r−α + 1 ] r−α r ×xβν(1−µ)+p− (β+α)(q+1) r +1. Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 429 Corollary 4. Let x > 0, α, β > 0, µ ∈ (0, 1) and let f ∈ AC1 (0, x) . (i) If r > max { 1, α, (1− µ)−1 } , then x∫ 0 ∣∣(CDµ 0+f ) (s) ∣∣β ∣∣∣∣ ddsf (s) ∣∣∣∣α ds ≤ Ω3x β(1−µ)−α+1 r +1  x∫ 0 ∣∣∣∣ ddsf (s) ∣∣∣∣r ds  α+β r , (41) where Ω3 = ( α α+β )α r (Γ (1− µ))−β ( r−1 (1−µ)r−1 )β(r−1) r [ β[(1−µ)r−1] r−α + 1 ] r−α r . (42) (ii) If 0 < r < min { α, 1, (1− µ)−1 } , then x∫ 0 ∣∣(CDµ 0+f ) (s) ∣∣β ∣∣∣∣ ddsf (s) ∣∣∣∣α ds ≥ Ω3x β(1−µ)−α+1 r +1  x∫ 0 ∣∣∣∣ ddsf (s) ∣∣∣∣r ds  α+β r , (43) where Γ is the Euler Gamma function and Ω3 is given by (42). Example 1. If we put α = 1, β = 1, r = 2, µ, ν ∈ (0, 1) , 2ν (1− µ) ≥ 1, γ, ω > 0, ν ≥ µγ, U (s) = 1, V (s) = 1 eγµ,ν(s,ω) in Theorem 4, by using the integral formula (see [18]) x∫ 0 (x− t)ν−1Eγµ,ν (ω (x− t)µ) tδ−1dt = Γ (δ)xν+δ−1Eγµ,ν+δ (ωxµ) we obtain ∆ (s) = s∫ 0 eγµ,ν (t, ω) [ 1 Γ (ν (1− µ)) (s− t)ν(1−µ)−1 ]2 dt = 1 Γ2 (ν (1− µ)) s∫ 0 tν−1Eγµ,ν (−ωtµ) (s− t)2[ν(1−µ)−1] dt = 1 Γ2 (ν (1− µ)) s∫ 0 (s− t)ν−1Eγµ,ν (−ω (s− t)µ) t2[ν(1−µ)−1]dt = Γ (2ν (1− µ)− 1) Γ2 (ν (1− µ)) sν+2[ν(1−µ)−1]Eγµ,ν+2ν(1−µ)−1 (−ωsµ) = 1 Γ (2ν (1− µ) + 1) eγµ,ν+2ν(1−µ)−1 (s, ω) . Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 430 Hence, Ω (x) = √ 2 2Γ (2ν (1− µ) + 1)  x∫ 0 eγµ,ν (s, ω) eγµ,ν+2ν(1−µ)−1 (s, ω) ds 1/2 . (44) By Lemma 2.2, we obtain that eγµ,ν (s, ω) eγµ,ν+2ν(1−µ)−1 (s, ω) > 0, for all s ∈ (0, x] , i.e. Ω (x) > 0, for all x > 0. By Theorem 4, we obtain, x∫ 0 ∣∣(Dµ,ν 0+ f ) (s) ∣∣ ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣ ds ≤ Ω (x)  x∫ 0 ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣2 eγµ,ν (s, ω) ds  , (45) where Ω (x) is given by (44). Theorem 5. Let x > 0, x ∈ I, α, β > 0, r > max (1, α) , µ ∈ (0, 1) , ν ∈ (0, 1] and let U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I. If f ∈ L (0, x) have an integrable fractional derivative Dµ+ν−µν 0+ f ∈ L∞ (0, x) , then∣∣∣∣∣∣ x∫ 0 U (s) ∣∣(Dµ,ν 0+ f ) (s) ∣∣β ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣α ds ∣∣∣∣∣∣ ≤ ( 1 Γ (ν (1− µ)) ) r−α r x∫ 0 U (λ) ∣∣∣∣∣∣ λ∫ 0 V (t) (λ− t)µ+ν−µν dt ∣∣∣∣∣∣ r−α r dλ× ‖V ‖β∞ ∥∥∥(Dµ+ν−µν 0+ f )∥∥∥α+β ∞ . If we take U = V = 1 in Theorem 5, since x∫ 0 ∣∣∣∣∣∣ λ∫ 0 (λ− t)µ+ν−µν dt ∣∣∣∣∣∣ r−α r dλ = 1 (µ+ ν − µν + 1) r−α r x∫ 0 λ(µ+ν−µν+1) r−α r dλ = x(µ+ν−µν+1) r−α r +1 (µ+ ν − µν + 1) r−α r [ (µ+ ν − µν + 1) r−α r + 1 ] , we get the following special inequality of Theorem 5. Corollary 5. Let x > 0, α, β > 0, r > max (1, α) , µ ∈ (0, 1) , ν ∈ (0, 1]. If f ∈ L (0, x) have an integrable fractional derivative Dµ+ν−µν 0+ f ∈ L∞ (0, x) , then Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 431 ∣∣∣∣∣∣ x∫ 0 ∣∣(Dµ,ν 0+ f ) (s) ∣∣β ∣∣∣(Dµ+ν−µν 0+ f ) (s) ∣∣∣α ds ∣∣∣∣∣∣ ≤ ( 1 Γ (ν (1− µ)) (µ+ ν − µν + 1) ) r−α r (46) × x(µ+ν−µν+1) r−α r +1[ (µ+ ν − µν + 1) r−α r + 1 ] ∥∥∥(Dµ+ν−µν 0+ f )∥∥∥α+β ∞ . Corollary 6. Let x > 0, x ∈ I, α, β > 0, r > max (1, α) , µ ∈ (0, 1) and let U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I. If f ∈ L (0, x) have an integrable fractional derivative f ∈ AC1 (0, x) , then∣∣∣∣∣∣ x∫ 0 U (s) ∣∣(CDµ 0+f ) (s) ∣∣β ∣∣∣∣ ddsf (s) ∣∣∣∣α ds ∣∣∣∣∣∣ (47) ≤ ( 1 Γ (1− µ) ) r−α r x∫ 0 U (λ) ∣∣∣∣∣∣ λ∫ 0 V (t) (λ− t) dt ∣∣∣∣∣∣ r−α r dλ ‖V ‖β∞ ∥∥∥∥( d ds f (s) )∥∥∥∥α+β ∞ . Moreover for U (s) = V (s) = 1, there holds∣∣∣∣∣∣ x∫ 0 ∣∣(CDµ 0+f ) (s) ∣∣β ∣∣∣∣ ddsf (s) ∣∣∣∣α ds ∣∣∣∣∣∣ ≤ ( rx 3r − 2α )( x2 2Γ (1− µ) ) r−α r ∥∥∥∥( d ds f (s) )∥∥∥∥α+β ∞ . (48) We present some interesting Opial type inequalities regarding Prabhakar integral op- erator (15) and Riemamn-Liouville integral operator. Theorem 6. Let x > 0, x ∈ I, α, β > 0, r > max (1, α) , µ ∈ (0, 1) , γ, ω > 0, µγ > ν − 1 > 0 and let U, V ∈ C (I) be such that U (s) ≥ 0 and V (s) > 0 for all s ∈ I. If h ∈ L (0, x) , then∣∣∣∣∣∣ x∫ 0 U (s) ∣∣∣(εγµ,ν,ω,0+h)(s) ∣∣∣β |h (s)|α ds ∣∣∣∣∣∣ ≤ C (x) ∣∣∣∣∣∣ x∫ 0 V (s) |h (s)|r ds ∣∣∣∣∣∣ (α+β)/r , (49) where C (x) = ( α α+ β )α/r Γ ( γ − ν−1 µ ) Γ ( ν−1 µ ) πµω ν−1 µ Γ (γ) [ cos (πµ 2 )]γ− ν−1 µ β (50) ×  x∫ 0 ( U r (s)V −α (s) )1/(r−α)  s∫ 0 (V (t))−1/(r−1) dt β(r−1)/(r−α) ds  (r−α)/r . Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 432 Corollary 7. Let x > 0 and h ∈ L (0, x) . If α, β > 0, r > max (1, α) , µ ∈ (0, 1) , γ, ω > 0, µγ > ν − 1 > 0, then ∣∣∣∣∣∣ x∫ 0 ∣∣∣(εγµ,ν,ω,0+h)(s) ∣∣∣β |h (s)|α ds ∣∣∣∣∣∣ ≤ C (x) ∣∣∣∣∣∣ x∫ 0 |h (s)|r ds ∣∣∣∣∣∣ (α+β)/r , (51) where C (x) = ( α α+β )α/r( Γ ( γ− ν−1 µ ) Γ ( ν−1 µ ) πµω ν−1 µ Γ(γ)[cos(πµ2 )] γ− ν−1 µ )β ( β(r−1) r−α + 1 ) r−α r x β(r−1)+r−α r . (52) Theorem 7. Let x > 0, x ∈ I, α, β > 0, r > max (1, α) , µ, ν, γ > 0, ω ∈ R and let U, V, h ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I. Then the following inequality holds true: ∣∣∣∣∣∣ x∫ 0 U (s) ∣∣∣(εγµ,ν,ω,0+h)(s) ∣∣∣β |h (s)|α ds ∣∣∣∣∣∣ (53) ≤ x∫ 0 U (λ) ∣∣∣∣∣∣ λ∫ 0 V (t) eγµ,ν (λ− t, ω) dt ∣∣∣∣∣∣ r−α r dλ ‖V ‖β∞ ‖h‖ α+β ∞ . If we take U = V = 1 and ω = 0 in Theorem 7, since x∫ 0 ∣∣∣∣∣∣ λ∫ 0 [ 1 Γ (ν) (λ− t)ν−1 ] dt ∣∣∣∣∣∣ r−α r dλ = rx r(ν + 1)− να ( xν Γ (ν + 1) ) r−α r we get the following Opial type inequality regarding Riemann-Liouville integral operator Iν0+h : Corollary 8. Let x > 0, x ∈ I, α, β > 0, r > max (1, α) , ν > 0. If h ∈ L (0, x) and h ∈ C(I), then x∫ 0 ∣∣(Iν0+h)(s) ∣∣β |h (s)|α ds ≤ rx r(ν + 1)− να ( xν Γ (ν + 1) ) r−α r ‖h‖α+β ∞ . (54) We present some Opial type inequalities for Prabhakar operator (15) and Caputo- Prabhakar derivative (12). Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 433 Theorem 8. Let x > 0, x ∈ I, f ∈ L (0, x), and let U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I, α, β > 0, µ, ν, γ > 0,m = [ν], and f ∈ ACm [0, x] . (i) If r > max (1, α) , then x∫ 0 U (s) ∣∣∣(CDγ µ,ν,ω,0+f ) (s) ∣∣∣β ∣∣∣f (m) (s) ∣∣∣α ds ≤ Ω4 (x)  x∫ 0 V (s) ∣∣∣f (m) (s) ∣∣∣r ds  α+β r , (55) where Ω4 (x) = ( α α+ β )α r  x∫ 0 ( U r (s)V −α (s) ) 1 r−α (∆ (s)) β(r−1) r−α ds  r−α r , (56) ∆ (s) = s∫ 0 (V (t))− 1 r−1 [ eγµ,m−ν (s− t, ω) ] r r−1 dt. (57) (ii) If r < max (1, α) , then x∫ 0 U (s) ∣∣∣(CDγ µ,ν,ω,0+f ) (s) ∣∣∣β ∣∣∣f (m) (s) ∣∣∣α ds ≥ Ω4 (x)  x∫ 0 V (s) ∣∣∣f (m) (s) ∣∣∣r ds  α+β r , (58) where Ω4 (x) is given by (56) and (57). Corollary 9. Let x > 0 and f ∈ L (0, x) , and let U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I, α, β > 0, µ, ν, γ > 0, ω ∈ R and f ∗ e−γµ,m−ν,ω ∈Wm,1(0, x), m = [ν] , f ∈ ACm [0, x] , f (k) (0+) = 0, k = 0, 1, 2, ...m− 1. (i) If r > max (1, α) , then x∫ 0 U (s) ∣∣∣(Dγ µ,ν,ω,0+f ) (s) ∣∣∣β ∣∣∣f (m) (s) ∣∣∣α ds ≤ Ω4 (x)  x∫ 0 V (s) ∣∣∣f (m) (s) ∣∣∣r ds  α+β r . (59) (ii) If r < max (1, α) , then x∫ 0 U (s) ∣∣∣(Dγ µ,ν,ω,0+f ) (s) ∣∣∣β ∣∣∣f (m) (s) ∣∣∣α ds ≥ Ω4 (x)  x∫ 0 V (s) ∣∣∣f (m) (s) ∣∣∣r ds  α+β r , (60) where Ω4 (x) is given by (56) and (57). Theorem 9. Let x > 0, h ∈ L (0, x) , x ∈ I, α, β > 0, r > max (1, α) , µ, ν, γ > 0 and let U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I. If m = [ν] , h ∈ ACm [0, x] , then ∣∣∣∣∣∣ x∫ 0 U (s) ∣∣∣(CDγ µ,ν,ω,0+h ) (s) ∣∣∣β ∣∣∣h(m) (s) ∣∣∣α ds ∣∣∣∣∣∣ (61) Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 434 ≤ x∫ 0 U (λ) ∣∣∣∣∣∣ λ∫ 0 V (t) e−γµ,m−ν (λ− t, ω) dt ∣∣∣∣∣∣ r−α r dλ ‖V ‖β∞ ∥∥∥h(m) ∥∥∥α+β ∞ . Theorem 10. Let x > 0, h ∈ L (0, x) , x ∈ I, and let U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I, α, β > 0, r > max (1, α) , µ, ν, γ > 0. If h ∗ e−γµ,m−ν,ω ∈ Wm,1(0, x), m = [ν] , h ∈ ACm [0, x] , h(k) (0+) = 0, k = 0, 1, 2, ...,m− 1, then∣∣∣∣∣∣ x∫ 0 U (s) ∣∣∣(Dγ µ,ν,ω,0+h ) (s) ∣∣∣β ∣∣∣h(m) (s) ∣∣∣α ds ∣∣∣∣∣∣ (62) ≤ x∫ 0 U (λ) ∣∣∣∣∣∣ λ∫ 0 V (t) e−γµ,m−ν (λ− t, ω) dt ∣∣∣∣∣∣ r−α r dλ ‖V ‖β∞ ∥∥∥h(m) ∥∥∥α+β ∞ . Theorem 11. Let x > 0, α, β, ρ > 0, µ ∈ (0, 1) , ν ∈ [0, 1] , γ, ω ∈ R and U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I. Also let f ∈ L (0, x) and f ∗ e−γ(1−ν) ρ, (1−ν)(1−µ), ω ∈ AC1(0, x). (i) If r > max {1, α} , then x∫ 0 U (s) ∣∣∣(Dγ, µ, ν ρ, ω, 0+f ) (s) ∣∣∣β ∣∣∣∣ dds (ε−γ(1−ν) ρ, (1−ν)(1−µ), ω, 0+f ) (s) ∣∣∣∣α ds (63) ≤ Ω5 (x)  x∫ 0 V (s) ∣∣∣∣ dds (ε−γ(1−ν) ρ, (1−ν)(1−µ), ω, 0+f ) (s) ∣∣∣∣r ds  α+β r , where Ω5 (x) = ( α α+ β )α r  x∫ 0 ( U r (s)V −α (s) ) 1 r−α (∆ (s)) β(r−1) r−α ds  r−α r , (64) ∆ (s) = s∫ 0 (V (t))− 1 r−1 [ e−γνρ, ν(1−µ) (s− t, ω) ] r r−1 dt. (65) (ii) If 0 < r < min {α, 1}, then x∫ 0 U (s) ∣∣∣(Dγ, µ, ν ρ, ω, 0+f ) (s) ∣∣∣β ∣∣∣∣ dds (ε−γ(1−ν) ρ, (1−ν)(1−µ), ω, 0+f ) (s) ∣∣∣∣α ds (66) ≥ Ω5 (x)  x∫ 0 V (s) ∣∣∣∣ dds (ε−γ(1−ν) ρ, (1−ν)(1−µ), ω, 0+f ) (s) ∣∣∣∣r ds  α+β r , where Ω5 (x) and ∆ (s) are given by (64) and (65). Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 435 Corollary 10. Let x > 0, f ∈ W 1,1 (0, x) , α, β, ρ > 0, µ ∈ (0, 1) , γ, ω ∈ R and U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I. (i) If r > max {1, α}, then x∫ 0 U (s) ∣∣∣(Dγ, µ ρ, ω, 0+f ) (s) ∣∣∣β ∣∣∣∣ ddsf (s) ∣∣∣∣α ds ≤ Ω6 (x)  x∫ 0 V (s) ∣∣∣∣ ddsf (s) ∣∣∣∣r ds  α+β r , (67) where Ω6 (x) = ( α α+ β )α r  x∫ 0 ( U r (s)V −α (s) ) 1 r−α (∆ (s)) β(r−1) r−α ds  r−α r , (68) ∆ (s) = s∫ 0 (V (t))− 1 r−1 [ e−γρ, 1−µ (s− t, ω) ] r r−1 dt. (69) (ii) If 0 < r < min {α, 1}, then x∫ 0 U (s) ∣∣∣(Dγ, µ ρ, ω, 0+f ) (s) ∣∣∣β ∣∣∣∣ ddsf (s) ∣∣∣∣α ds ≥ Ω6 (x)  x∫ 0 V (s) ∣∣∣∣ ddsf (s) ∣∣∣∣r ds  α+β r , (70) where Ω6 (x) and ∆ (s) are given by (68) and (69). Finally, we present Opial type inequalities regarding Hilfer-Prabhakar operator. Theorem 12. Let x > 0, α, β, ρ > 0, µ ∈ (0, 1) , ν ∈ [0, 1] , γ, ω ∈ R and U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I and f ∈ L (0, x) , f ∗ e−γ(1−ν) ρ, (1−ν)(1−µ), ω ∈ AC1(0, x). If r > max {1, α} , then∣∣∣∣∣∣ x∫ 0 U (s) ∣∣∣(Dγ, µ, ν ρ, ω, 0+f ) (s) ∣∣∣β ∣∣∣∣ dds (ε−γ(1−ν) ρ, (1−ν)(1−µ), ω, 0+f ) (s) ∣∣∣∣α ds ∣∣∣∣∣∣ ≤ x∫ 0 U (λ) ∣∣∣∣∣∣ λ∫ 0 V (t) e−γνρ, ν(1−µ) (λ− t, ω) dt ∣∣∣∣∣∣ r−α r dλ× ‖V ‖β∞ ∥∥∥∥ dds (ε−γ(1−ν) ρ, (1−ν)(1−µ), ω, 0+f ) (s) ∥∥∥∥α+β ∞ . Corollary 11. Let x > 0, α, β, ρ > 0, µ ∈ (0, 1) , γ, ω ∈ R and U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I and f ∈ L (0, x) , f ∈ AC1(0, x). If r > max {1, α}, then ∣∣∣∣∣∣ x∫ 0 U (s) ∣∣∣(Dγ, µ ρ, ω, 0+f ) (s) ∣∣∣β ∣∣∣∣ ddsf (s) ∣∣∣∣α ds ∣∣∣∣∣∣ (71) Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 436 ≤ x∫ 0 U (λ) ∣∣∣∣∣∣ λ∫ 0 V (t) e−γρ, (1−µ) (λ− t, ω) dt ∣∣∣∣∣∣ r−α r dλ ‖V ‖β∞ ∥∥∥∥ ddsf (s) ∥∥∥∥α+β ∞ . 4. Further Generalizations In this section we give Opial–type integral inequalities for fractional integral operator containing more generalized Mittag–Leffler function in the kernel [19]. Definition 6. Let µ, ν, k, l, γ be positive real numbers and ω ∈ R. Then the generalized fractional integral operator containing Mittag–Leffler function εγ,δ,k µ,ν,l,ω,a+ for a real valued continuous function f is defined by: (εγ,δ,k µ,ν,l,ω,a+ f)(x) = ∫ x a (x− t)ν−1Eγ,δ,kµ,ν,l (ω(x− t)µ)f(t)dt, (72) where the function Eγ,δ,kµ,ν,l is generalized Mittag–Leffler function defined as Eγ,δ,kµ,ν,l (t) = ∞∑ n=0 (γ)kn Γ(µn+ ν) tn (δ)ln . (73) If δ = l = 1 in (72), then integral operator εγ,δ,k µ,ν,l,ω,a+ reduces to an integral operator containing generalized Mittag–Leffler function Eγ,1,kµ,ν,1 introduced by Srivastava, and To- movski in [20]. Along δ = l = 1 in addition if k = 1 (72) reduces to an integral operator defined by Prabhakar in [18] containing Mittag-Leffler function Eγµ,ν . For ω = 0 in (72), integral operator εγ,δ,k µ,ν,l,ω,a+ would correspond essentially to the right-handed Riemann– Liouville fractional integral operators. Here we present some general results involving generalized fractional integral operator, εγ,δ,k α,β,l,ω,a+ containing more general form of Mittag–Leffler function Eγ,δ,kµ,ν,l . Theorem 13. Let x > 0, α, β, µ, ν, k, l, γ > 0 with k < l+µ, ν > 1 and r > max { 1, α, 1 ν } , also let U, V ∈ C (I) be such that U (s) ≥ 0, V (s) > 0 for all s ∈ I. Then for ω ∈ R and f ∈ L (0, x) we have x∫ 0 U (s) ∣∣∣(εγ,δ,kµ,ν,l,ω,a+ f ) (s) ∣∣∣β |f (s)|α ds ≤ Ω (x)  x∫ 0 V (s) |f (s)|r ds  α+β r , (74) where Ω (x) = ( α α+ β )α r  x∫ 0 ( U r (s)V −α (s) ) 1 r−α (∆ (s)) β(r−1) r−α ds  r−α r , (75) ∆ (s) = s∫ 0 (V (t))− 1 r−1 ( Eγ,δ,kµ,ν,l (ω(s− t)µ)(s− t)ν−1 ) r r−1 dt. (76) Z. Tomovski, J. Pečarić and G. Farid / Eur. J. Pure Appl. Math, 10 (3) (2017), 419-439 437 Proof. According to (72), (εγ,δ,k µ,ν,l,ω,a+ f)(s) = ∫ s a (s− t)ν−1Eγ,δ,kµ,ν,l (ω(s− t)µ)f(t)dt, by setting y (s) = (εγ,δ,k µ,ν,l,ω,a+ f)(s), h (s) = f (s) , Φ (s, t) = Eγ,δ,kµ,ν,l (ω(s− t)µ) (s− t)ν−1 , we observe that condition (2) is satisfied with a = 0 and I = [0, x] : |y (s)| ≤ s∫ 0 Φ (s, t) |h (t)| dt, 0 ≤ s ≤ x. The rest of the proof of is the same as Theorem 4.2 of [14]. Corollary 12. Let x > 0, α, β, µ, ν, k, l, γ > 0 with k < l+µ, ν > 1 and r > max { 1, α, 1 ν } . Then for ω ∈ R and f ∈ L (0, x) we have x∫ 0 ∣∣∣(εγ,δ,kµ,ν,l,ω,a+ f ) (s) ∣∣∣β |f (s)|α ds ≤ ( α α+ β )α r × ∫ x 0 (∫ s 0 ( Eγ,δ,kµ,ν,l (ω(s− t)µ)(s− t)ν−1 ) r r−1 dt )β(r−1) r−α ds  (r−α) r  x∫ 0 |f (s)|r ds  α+β r . (77) Remark 2. If δ = l = 1 in above results, then we obtain results involving integral operator εγ,1,k µ,ν,1,ω,a+ containing generalized Mittag–Leffler function Eγ,1,kµ,ν,1 introduced by Srivastava, and Tomovski in [20]. Along δ = l = 1 in addition if k = 1, then we obtain results involving integral operator defined by Prabhakar in [18] containing Mittag-Leffler function Eγµ,ν . If ω = 0, then we obtain results right-handed Riemann–Liouville fractional integral operator (see, [19]). Similar inequalities of Opial type can also be obtained for integral operators which contain multinomial Mittag–Leffler function [10] and Multiindex Mittag- Leffler function [13] in the kernel. Acknowledgements The author Zivorad Tomovski is supported under the European Commission and the Croatian Ministry of Science, Education and Sports Co-Financing Agreement No. 291823. In particular, ZT acknowledges project financing from the Maria Curie FP7-PEOPLE- 2011-COFUND program NEWFELPRO Grant Agreement No. 37 – Anomalous diffusion. Author Ghulam Farid is supported by COMSATS Institute of Information Technology, Islamabad Pakistan. REFERENCES 438 References [1] R P Agarwal and P Y H Pang. Opial Inequalities with Applications in Differential and Difference Equations. Kluwer Academic Publishers, Dordrecht, Boston, London 1995. [2] G A Anastassiou. Advanced inequalities. 11, World Scientific, 2011. [3] M Andrić, A Barbir G. Farid and J. Pečarić. More on certain Opial–type inequality for fractional derivatives. Nonlinear Functional Analysis and Applications, 19, No. 4, 565–583, 2014. [4] M Andrić, J Pečarić and I Perić. Improvements of composition rule for the Canavati fractional derivatives and applications to Opial–type inequalities. Dynam. Systems. Appl. 20, 383–394, 2011. [5] G Farid and J Pečarić. Opial type integral inequalities for fractional derivatives. Fractional Differential Calculus, 2, No. 1, 31–54, 2012. [6] G Farid and J Pečarić. Opial type integral inequalities for fractional derivatives II. Fractional Differential Calculus, 2, No. 2, 139–155, 2012. [7] G Farid and J Pečarić. Opial type integral Inequalities for Widder derivatives and linear differential operators. Int. J. Anal. Appl. Vol. 7, No. 1, 38–49, 2015. [8] G Farid J Pečarić and Z Tomovski. Opial type integral Inequalities for fractional integral operator involving Mittag-Leffler function. Fractional Differential Calculus, 5, No. 1, 93–106, 2015. [9] R Garra, R Gorenflo, F Polito and Z Tomovski. Hilfer-Prabhakar Derivatives and some applications. Applied Mathematics and Computation, Vol. 242, 576-589, 2014. [10] R Hilfer, Y Luchko and Z Tomovski. Operational method for the solution of fractional differential equation with generalized Riemann-Liouville fractional derivatives. Frac. Calc. Appl. Ana. Vol. 12 (3), 299–318, 2009. [11] A A Kilbas, M Saigo and R K Saxena. Generalized Mittag-Leffler function and gener- alized fractional calculus operators. Integral Transform. Spec. Funct. 15, 31–49, 2004. [12] A A Kilbas, H M Srivastava and J J Trujillo. Theory and Applications of fractional differential equations. North-Holland Mathematics Studies, 204, Elsevier, New York- London, 2006. [13] V Kiryakova. Multiple (multiindex ) Mittag-Leffler functions and relations to gener- alized fractional calculus. J. Computational Appl. Math. 118, 241-259, 2000. [14] J J Koliha and J Pečarić. Weighted Opial inequalities. Tamkang J. Mathematics, Vol. 33 (1), 83–92, 2002. REFERENCES 439 [15] K Miller and B Ross. An introduction to the fractional calculus and fractional differ- ential Equations. John Wiley and Sons Inc. New York, 1993. [16] K Oldham and J Spanier. The fractional calculus. Academic Press, New York - Lon- don, 1974. [17] Z Opial. Sur une inégalité. Ann. Polon. Math. 8, 29–32, 1960. [18] T R Prabhakar. A singular integral equation with a generalized Mittag-Leffler function in the kernel. Yokohama Math. J., 19, 7–15, 1971. [19] T O Salim and A W Faraj. A Generalization of Mittag–Leffler function and integral operator associated with fractional calculus. J. Fract. Calc. Appl. Vol. 3, No. 5, 1–13, 2012. [20] H M Srivastava and Ž Tomovski. Fractional calculus with an integral operator con- taining generalized Mittag–Leffler function in the kernel. Appl. Math. Comput., 211, 198–210, 2009. [21] Z Tomovski, R Hilfer and H M Srivastava. Fractional and operational calculus with generalized fractional derivative operators and Mittag-Leffler functions. Inte- gral Transform Spec. Funct. Vol. 21, No.11, 797–814, 2010. [22] Z Tomovski, T K Pogany and H M Srivastava. Laplace type integral expressions for a certain three-parameter family of generalized Mittag-Leffler functions with applica- tions involving complete monotonicity. J. Franklin Institute, 351, 5437–5454, 2014. [23] Z Tomovski and R Garra. Analytic solutions of fractional integro-differential equations of Volterra type with variable coefficients. Fract. Calc. Appl. Anal. , 17 (1), 38–60, 2014.