id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bam-10511	Gonzalez, Andrea; Abrigo, Johanna ; Achiardi, Oscar; Simon, Felipe ; Cabello-Verrugio, Claudio	Intensive care unit-acquired weakness: A review from molecular mechanisms to its impact in COVID-2019	2022	18	.pdf	application/pdf	13294	1006	59	ICU-acquired weakness Muscle weakness is a frequent problem in ICU patients, and it can be induced due to primary or secondary causes. Pronounced muscle wasting in ICU patients could be explained by mechanical unloading due to immobilisation/denervation and the catabolic state of critical illness, with reduced anabolism.5,14 Activated proteolytic systems have been observed in type II fibres, together with myosinolysis (proteolytic degradation of Intensive care unit-acquired weakness in COVID-2019 Eur J Transl Myol 32 (3): 10511, 2022 doi: 10.4081/ejtm.2022.10511 - 3 - myosin), consistent with primary myopathy and neurogenic muscle atrophy.2,25 These pathological disorders translate clinically into loss of strength and muscle mass, weakness, and significant functional disorders in activities of daily living, which are independent predictors of mortality in critically ill patients.	cache/bam-10511.pdf	txt/bam-10511.txt