id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bam-11856	Dowling, Paul; Swandulla, Dieter; Ohlendieck, Kay	Cellular pathogenesis of Duchenne muscular dystrophy: progressive myofibre degeneration, chronic inflammation, reactive myofibrosis and satellite cell dysfunction	2023	21	.pdf	application/pdf	14854	1394	59	As summarized in Figure 2, stem cell dysfunction plays a crucial part in the dystrophic pathogenesis and involves the disruption of cellular polarity, the loss of asymmetric cell division and a reduction in properly activated myogenic progenitor cells.15,86 In contrast to multi- nucleated and large sized myofibres, muscle stem cells (MuSCs) are a small, mono-nucleated and multi-potent cell type that is positioned between the sarcolemma and basal lamina of mature skeletal muscle fibres.6-8 The pool of available MuSCs is provided by a highly regulated process of self-renewal,7 and combined with the essential creation of myogenic progenitor cells,8 for repair and regeneration of adult myofibres.14 Figure 3 outlines the main steps involved in regenerative myogenesis. Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division.	cache/bam-11856.pdf	txt/bam-11856.txt