id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bam-13497	Safarpour Lima, Behzad; Sayanjali, Shima; Shoham-Hazon, Nir	Effect of estrogen and progesterone therapy on intraocular pressure: a systematic review and meta-analysis study	2025	8	.pdf	application/pdf	4556	247	50	This is thought to be due to the in- fluence of estrogen on the ocular tissues, where it may enhance aqueous humor outflow or reduce its production, thereby lowering IOP.12-14 Conversely, other studies have found no significant association or even reported an in- crease in IOP with HRT use, indicating that the effect of hormone therapy on IOP might be more complex and in- fluenced by various factors such as the type of hormone used, dosage, duration of therapy, and individual patient characteristics.15-17 Furthermore, understanding the role of hormone therapy in IOP modulation has broader implications for women’s health. If hormone therapy is shown to have a signif- icant impact on IOP, it could inform clinical guidelines for glaucoma management and highlight the importance of in- dividualized therapy based on hormonal status.21,22 In this systematic review and meta-analysis, we aim to ex- amine the effect of estrogen and progesterone therapy on IOP in postmenopausal women by synthesizing the ev- idence from existing studies.	cache/bam-13497.pdf	txt/bam-13497.txt