id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bam-7373	Albertin, Giovanna; Kern, Helmut; Hofer, Christian; Guidolin, Diego; Porzionato, Andrea; Rambaldo, Anna; De Caro, Raffaele; Piccione, Francesco; Marcante, Andrea; Zampieri, Sandra	Two years of Functional Electrical Stimulation by large surface electrodes for denervated muscles improve skin epidermis in SCI	2018	5	.pdf	application/pdf	3286	198	54	Key Words: spinal cord injury, denervated-degenerating muscle, long-term effects, h-bFES, skin biopsy, morphometry of epidermis Eur J Transl Myol 28 (1): 141-145, 2018 We previously showed that atrophic leg muscles from spinal cord injury patients suffering with complete conus and cauda equina lesions, and thus with permanent- denervation atrophy/degeneration of muscles (DDM), were almost completely rescued to normal size after two years of home-based Functional Electrical Stimulation (h-bFES) with the impressive improvements of the FES- induced muscle strength, of the muscle bulk and of the size of the muscle fibers.1-13 Since we used large surface electrodes to stimulate the thigh muscles,14 we wanted to know if the electrical stimulated skin was either negatively or positively affected.15 To evaluate neuronal and trophism biomarkers in the skin biopsies of those patients we are performing immunohistochemistry of skin cross sections from a subsets of patients enrolled in the EU Project RISE.2 Morphometric analyses of the area of epidermis determined in skin cross sections before and after two years of h-bFES support our recently published evidence of an increase of skin thickness randomly quantified in the biopsies.15 Materials and Methods Histologic morphometry of skin biopsies The harvested skin biopsies were fixed in 10% buffered formalin and embedded in paraffin.	cache/bam-7373.pdf	txt/bam-7373.txt