id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bam-7688	Pietrangelo, Tiziana; Fulle, Stefania; Coscia, Francesco; Gigliotti, Paola Virginia; Fanò-Illic, Giorgio	Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome	2018	9	.pdf	application/pdf	6509	333	44	Although cumulative oxidative damage has been suggested to induce age-associated decline in mitochondrial function, the effects of mitochondrial dysfunction and mtROS in age-related muscle atrophy remains a controversial topic.38 Elevated ROS levels have been associated, in CFS / ME muscles, with alterations in mitochondrial function with a consequent reduction in the rate of ATP synthesis and impairment of cellular bioenergetics and, as consequence of this to muscle fatigue. The same group also demonstrated specific oxidative alterations in the vastus lateralis muscle of CFS patients, both as an increased value of oxidative damage markers (8OH-dG, MDA) and membrane fluidity, and an imbalance in the oxidant-antioxidant system.19 These findings are in agreement with the hypothesis that impairment of mitochondrial activity underlies an increase in the production of ROS that leads to muscle fatigue, similar to normal ageing.41 In the muscles of CFS / ME patients, many of the reported alterations may be the consequence of oxidative damage.	cache/bam-7688.pdf	txt/bam-7688.txt