id sid tid token lemma pos bam-12413 1 1 layout layout NOUN bam-12413 1 2 1 1 NUM bam-12413 1 3 thematic thematic ADJ bam-12413 1 4 section section NOUN bam-12413 1 5 : : PUNCT bam-12413 1 6 advances advance NOUN bam-12413 1 7 in in ADP bam-12413 1 8 musculoskeletal musculoskeletal ADJ bam-12413 1 9 and and CCONJ bam-12413 1 10 neuromuscular neuromuscular ADJ bam-12413 1 11 rehabilitation rehabilitation NOUN bam-12413 1 12 | | NOUN bam-12413 1 13 maccarone maccarone PROPN bam-12413 1 14 & & CCONJ bam-12413 1 15 masiero masiero PROPN bam-12413 1 16 eur eur PROPN bam-12413 1 17 j j PROPN bam-12413 1 18 transl transl PROPN bam-12413 1 19 myol myol NOUN bam-12413 1 20 34 34 NUM bam-12413 1 21 ( ( PUNCT bam-12413 1 22 3 3 NUM bam-12413 1 23 ) ) PUNCT bam-12413 1 24 12413 12413 NUM bam-12413 1 25 , , PUNCT bam-12413 1 26 2024 2024 NUM bam-12413 1 27 doi doi NOUN bam-12413 1 28 : : PUNCT bam-12413 1 29 10.4081 10.4081 NUM bam-12413 1 30 / / SYM bam-12413 1 31 ejtm.2024.12413 ejtm.2024.12413 PROPN bam-12413 1 32 introduction introduction NOUN bam-12413 1 33 osteoarthritis osteoarthritis NOUN bam-12413 1 34 osteoarthritis osteoarthritis NOUN bam-12413 1 35 ( ( PUNCT bam-12413 1 36 oa oa X bam-12413 1 37 ) ) PUNCT bam-12413 1 38 is be AUX bam-12413 1 39 a a DET bam-12413 1 40 debilitating debilitate VERB bam-12413 1 41 chronic chronic ADJ bam-12413 1 42 degenerative degenerative ADJ bam-12413 1 43 disease disease NOUN bam-12413 1 44 that that PRON bam-12413 1 45 affects affect VERB bam-12413 1 46 over over ADP bam-12413 1 47 300 300 NUM bam-12413 1 48 million million NUM bam-12413 1 49 patients patient NOUN bam-12413 1 50 worldwide worldwide ADV bam-12413 1 51 . . PUNCT bam-12413 2 1 oa oa PROPN bam-12413 2 2 is be AUX bam-12413 2 3 characterized characterize VERB bam-12413 2 4 by by ADP bam-12413 2 5 joint joint ADJ bam-12413 2 6 pain pain NOUN bam-12413 2 7 and and CCONJ bam-12413 2 8 dysfunction dysfunction NOUN bam-12413 2 9 , , PUNCT bam-12413 2 10 progressive progressive ADJ bam-12413 2 11 loss loss NOUN bam-12413 2 12 of of ADP bam-12413 2 13 autonomy autonomy NOUN bam-12413 2 14 in in ADP bam-12413 2 15 activities activity NOUN bam-12413 2 16 of of ADP bam-12413 2 17 daily daily ADJ bam-12413 2 18 living living NOUN bam-12413 2 19 ( ( PUNCT bam-12413 2 20 adl adl PROPN bam-12413 2 21 ) ) PUNCT bam-12413 2 22 , , PUNCT bam-12413 2 23 and and CCONJ bam-12413 2 24 worsening worsen VERB bam-12413 2 25 of of ADP bam-12413 2 26 quality quality NOUN bam-12413 2 27 of of ADP bam-12413 2 28 life life NOUN bam-12413 2 29 ( ( PUNCT bam-12413 2 30 qol).1,2 qol).1,2 VERB bam-12413 2 31 in in ADP bam-12413 2 32 particular particular ADJ bam-12413 2 33 , , PUNCT bam-12413 2 34 knee knee NOUN bam-12413 2 35 osteoarthritis osteoarthritis NOUN bam-12413 2 36 has have VERB bam-12413 2 37 a a DET bam-12413 2 38 prevalence prevalence NOUN bam-12413 2 39 of of ADP bam-12413 2 40 10 10 NUM bam-12413 2 41 % % NOUN bam-12413 2 42 and and CCONJ bam-12413 2 43 13 13 NUM bam-12413 2 44 % % NOUN bam-12413 2 45 respectively respectively ADV bam-12413 2 46 in in ADP bam-12413 2 47 men man NOUN bam-12413 2 48 and and CCONJ bam-12413 2 49 women woman NOUN bam-12413 2 50 aged age VERB bam-12413 2 51 above above ADP bam-12413 2 52 60 60 NUM bam-12413 2 53 years.3 years.3 PROPN bam-12413 2 54 joints joint NOUN bam-12413 2 55 affected affect VERB bam-12413 2 56 by by ADP bam-12413 2 57 oa oa NOUN bam-12413 2 58 show show VERB bam-12413 2 59 a a DET bam-12413 2 60 progressive progressive ADJ bam-12413 2 61 degradation degradation NOUN bam-12413 2 62 of of ADP bam-12413 2 63 articular articular ADJ bam-12413 2 64 cartilage cartilage NOUN bam-12413 2 65 , , PUNCT bam-12413 2 66 a a DET bam-12413 2 67 thickening thickening NOUN bam-12413 2 68 and and CCONJ bam-12413 2 69 sclerosis sclerosis NOUN bam-12413 2 70 of of ADP bam-12413 2 71 subchondral subchondral ADJ bam-12413 2 72 bone bone NOUN bam-12413 2 73 , , PUNCT bam-12413 2 74 formation formation NOUN bam-12413 2 75 of of ADP bam-12413 2 76 pseudocysts pseudocyst NOUN bam-12413 2 77 and and CCONJ bam-12413 2 78 osteophytes osteophyte NOUN bam-12413 2 79 , , PUNCT bam-12413 2 80 inflammation inflammation NOUN bam-12413 2 81 of of ADP bam-12413 2 82 synovium synovium NOUN bam-12413 2 83 or or CCONJ bam-12413 2 84 bursa bursa NOUN bam-12413 2 85 , , PUNCT bam-12413 2 86 the the DET bam-12413 2 87 hypertrophy hypertrophy NOUN bam-12413 2 88 of of ADP bam-12413 2 89 joint joint ADJ bam-12413 2 90 capsule capsule NOUN bam-12413 2 91 , , PUNCT bam-12413 2 92 and and CCONJ bam-12413 2 93 possible possible ADJ bam-12413 2 94 associated associated ADJ bam-12413 2 95 degeneration degeneration NOUN bam-12413 2 96 of of ADP bam-12413 2 97 ligaments ligament NOUN bam-12413 2 98 and and CCONJ bam-12413 2 99 menisci.4 menisci.4 NOUN bam-12413 2 100 articular articular ADJ bam-12413 2 101 cartilage cartilage NOUN bam-12413 2 102 consists consist VERB bam-12413 2 103 of of ADP bam-12413 2 104 95 95 NUM bam-12413 2 105 % % NOUN bam-12413 2 106 of of ADP bam-12413 2 107 water water NOUN bam-12413 2 108 and and CCONJ bam-12413 2 109 extracellular extracellular ADJ bam-12413 2 110 matrix matrix NOUN bam-12413 2 111 and and CCONJ bam-12413 2 112 only only ADV bam-12413 2 113 5 5 NUM bam-12413 2 114 % % NOUN bam-12413 2 115 of of ADP bam-12413 2 116 chondrocytes chondrocyte NOUN bam-12413 2 117 , , PUNCT bam-12413 2 118 the the DET bam-12413 2 119 cellular cellular ADJ bam-12413 2 120 elements element NOUN bam-12413 2 121 responsible responsible ADJ bam-12413 2 122 for for ADP bam-12413 2 123 proteoglycans proteoglycan NOUN bam-12413 2 124 and and CCONJ bam-12413 2 125 glycosaminoglycans glycosaminoglycan NOUN bam-12413 2 126 synthesis.5 synthesis.5 PROPN bam-12413 2 127 oa oa PROPN bam-12413 2 128 starts start VERB bam-12413 2 129 with with ADP bam-12413 2 130 the the DET bam-12413 2 131 alteration alteration NOUN bam-12413 2 132 of of ADP bam-12413 2 133 the the DET bam-12413 2 134 normal normal ADJ bam-12413 2 135 process process NOUN bam-12413 2 136 of of ADP bam-12413 2 137 remodeling remodeling NOUN bam-12413 2 138 of of ADP bam-12413 2 139 articular articular ADJ bam-12413 2 140 cartilage cartilage NOUN bam-12413 2 141 , , PUNCT bam-12413 2 142 with with ADP bam-12413 2 143 a a DET bam-12413 2 144 consequent consequent ADJ bam-12413 2 145 increase increase NOUN bam-12413 2 146 in in ADP bam-12413 2 147 the the DET bam-12413 2 148 content content NOUN bam-12413 2 149 of of ADP bam-12413 2 150 proteoglycans proteoglycan NOUN bam-12413 2 151 and and CCONJ bam-12413 2 152 subsequent subsequent ADJ bam-12413 2 153 increase increase NOUN bam-12413 2 154 of of ADP bam-12413 2 155 catabolic catabolic ADJ bam-12413 2 156 cytokines cytokine NOUN bam-12413 2 157 , , PUNCT bam-12413 2 158 including include VERB bam-12413 2 159 interleukin-1β interleukin-1β NOUN bam-12413 2 160 , , PUNCT bam-12413 2 161 which which PRON bam-12413 2 162 promotes promote VERB bam-12413 2 163 the the DET bam-12413 2 164 increase increase NOUN bam-12413 2 165 of of ADP bam-12413 2 166 synthesis synthesis NOUN bam-12413 2 167 of of ADP bam-12413 2 168 metalloproteases.6 metalloproteases.6 PROPN bam-12413 2 169 synovial synovial ADJ bam-12413 2 170 damage damage NOUN bam-12413 2 171 is be AUX bam-12413 2 172 often often ADV bam-12413 2 173 secondary secondary ADJ bam-12413 2 174 to to ADP bam-12413 2 175 cartilage cartilage NOUN bam-12413 2 176 and and CCONJ bam-12413 2 177 bone bone NOUN bam-12413 2 178 damage damage NOUN bam-12413 2 179 and and CCONJ bam-12413 2 180 consists consist VERB bam-12413 2 181 of of ADP bam-12413 2 182 a a DET bam-12413 2 183 reactive reactive ADJ bam-12413 2 184 inflammatory inflammatory ADJ bam-12413 2 185 thickening thickening NOUN bam-12413 2 186 resulting result VERB bam-12413 2 187 from from ADP bam-12413 2 188 increased increase VERB bam-12413 2 189 activity activity NOUN bam-12413 2 190 of of ADP bam-12413 2 191 synoviocytes synoviocyte NOUN bam-12413 2 192 ; ; PUNCT bam-12413 2 193 this this DET bam-12413 2 194 process process NOUN bam-12413 2 195 leads lead VERB bam-12413 2 196 to to ADP bam-12413 2 197 an an DET bam-12413 2 198 increase increase NOUN bam-12413 2 199 in in ADP bam-12413 2 200 the the DET bam-12413 2 201 synthesis synthesis NOUN bam-12413 2 202 of of ADP bam-12413 2 203 low low ADJ bam-12413 2 204 molecular molecular ADJ bam-12413 2 205 weight weight NOUN bam-12413 2 206 hyaluronic hyaluronic ADJ bam-12413 2 207 acid acid NOUN bam-12413 2 208 , , PUNCT bam-12413 2 209 with with ADP bam-12413 2 210 subsequent subsequent ADJ bam-12413 2 211 alteration alteration NOUN bam-12413 2 212 of of ADP bam-12413 2 213 the the DET bam-12413 2 214 synovial synovial ADJ bam-12413 2 215 fluid.4 fluid.4 NOUN bam-12413 2 216 the the DET bam-12413 2 217 clinical clinical ADJ bam-12413 2 218 manifestations manifestation NOUN bam-12413 2 219 of of ADP bam-12413 2 220 osteoarthritis osteoarthritis NOUN bam-12413 2 221 are be AUX bam-12413 2 222 represented represent VERB bam-12413 2 223 by by ADP bam-12413 2 224 pain pain NOUN bam-12413 2 225 and and CCONJ bam-12413 2 226 functional functional ADJ bam-12413 2 227 limitation limitation NOUN bam-12413 2 228 with with ADP bam-12413 2 229 variable variable ADJ bam-12413 2 230 characteristics characteristic NOUN bam-12413 2 231 depending depend VERB bam-12413 2 232 on on ADP bam-12413 2 233 the the DET bam-12413 2 234 joint joint NOUN bam-12413 2 235 involved involve VERB bam-12413 2 236 . . PUNCT bam-12413 3 1 arthritic arthritic ADJ bam-12413 3 2 pain pain NOUN bam-12413 3 3 often often ADV bam-12413 3 4 begins begin VERB bam-12413 3 5 insidiously insidiously ADJ bam-12413 3 6 ; ; PUNCT bam-12413 3 7 it it PRON bam-12413 3 8 is be AUX bam-12413 3 9 usually usually ADV bam-12413 3 10 localized localize VERB bam-12413 3 11 and and CCONJ bam-12413 3 12 accentuated accentuate VERB bam-12413 3 13 with with ADP bam-12413 3 14 joint joint ADJ bam-12413 3 15 load load NOUN bam-12413 3 16 , , PUNCT bam-12413 3 17 while while SCONJ bam-12413 3 18 it it PRON bam-12413 3 19 tends tend VERB bam-12413 3 20 to to PART bam-12413 3 21 recede recede VERB bam-12413 3 22 during during ADP bam-12413 3 23 the the DET bam-12413 3 24 night night NOUN bam-12413 3 25 hours hour NOUN bam-12413 3 26 abstract abstract ADJ bam-12413 3 27 osteoarthritis osteoarthritis NOUN bam-12413 3 28 ( ( PUNCT bam-12413 3 29 oa oa X bam-12413 3 30 ) ) PUNCT bam-12413 3 31 is be AUX bam-12413 3 32 a a DET bam-12413 3 33 disabling disable VERB bam-12413 3 34 disease disease NOUN bam-12413 3 35 that that PRON bam-12413 3 36 causes cause VERB bam-12413 3 37 pain pain NOUN bam-12413 3 38 and and CCONJ bam-12413 3 39 functional functional ADJ bam-12413 3 40 limitation limitation NOUN bam-12413 3 41 . . PUNCT bam-12413 4 1 oa oa PROPN bam-12413 4 2 symptoms symptom NOUN bam-12413 4 3 can can AUX bam-12413 4 4 be be AUX bam-12413 4 5 treated treat VERB bam-12413 4 6 with with ADP bam-12413 4 7 intra intra ADJ bam-12413 4 8 - - ADJ bam-12413 4 9 articular articular ADJ bam-12413 4 10 injections injection NOUN bam-12413 4 11 of of ADP bam-12413 4 12 anti anti ADJ bam-12413 4 13 - - ADJ bam-12413 4 14 inflammatory inflammatory ADJ bam-12413 4 15 , , PUNCT bam-12413 4 16 viscosupplementary viscosupplementary ADJ bam-12413 4 17 , , PUNCT bam-12413 4 18 or or CCONJ bam-12413 4 19 viscoinductive viscoinductive ADJ bam-12413 4 20 products product NOUN bam-12413 4 21 . . PUNCT bam-12413 5 1 non non NOUN bam-12413 5 2 - - NOUN bam-12413 5 3 responders responder NOUN bam-12413 5 4 to to ADP bam-12413 5 5 these these DET bam-12413 5 6 approaches approach NOUN bam-12413 5 7 have have VERB bam-12413 5 8 limited limited ADJ bam-12413 5 9 options option NOUN bam-12413 5 10 , , PUNCT bam-12413 5 11 often often ADV bam-12413 5 12 surgical surgical ADJ bam-12413 5 13 ( ( PUNCT bam-12413 5 14 e.g. e.g. ADV bam-12413 5 15 knee knee NOUN bam-12413 5 16 replacement replacement NOUN bam-12413 5 17 ) ) PUNCT bam-12413 5 18 . . PUNCT bam-12413 6 1 this this DET bam-12413 6 2 retrospective retrospective ADJ bam-12413 6 3 study study NOUN bam-12413 6 4 aims aim VERB bam-12413 6 5 to to PART bam-12413 6 6 evaluate evaluate VERB bam-12413 6 7 the the DET bam-12413 6 8 efficacy efficacy NOUN bam-12413 6 9 of of ADP bam-12413 6 10 a a DET bam-12413 6 11 single single ADJ bam-12413 6 12 injection injection NOUN bam-12413 6 13 of of ADP bam-12413 6 14 carboxymethyl carboxymethyl NOUN bam-12413 6 15 - - PUNCT bam-12413 6 16 chitosan chitosan NOUN bam-12413 6 17 for for ADP bam-12413 6 18 advanced advanced ADJ bam-12413 6 19 ( ( PUNCT bam-12413 6 20 kellgren kellgren NOUN bam-12413 6 21 - - PUNCT bam-12413 6 22 lawrence lawrence PROPN bam-12413 6 23 ≥3 ≥3 PROPN bam-12413 6 24 ) ) PUNCT bam-12413 6 25 and and CCONJ bam-12413 6 26 symptomatic symptomatic ADJ bam-12413 6 27 knee knee NOUN bam-12413 6 28 oa oa X bam-12413 6 29 in in ADP bam-12413 6 30 non non NOUN bam-12413 6 31 - - NOUN bam-12413 6 32 responders responder NOUN bam-12413 6 33 to to PART bam-12413 6 34 hyaluronic hyaluronic ADJ bam-12413 6 35 acid acid NOUN bam-12413 6 36 . . PUNCT bam-12413 7 1 we we PRON bam-12413 7 2 enrolled enrol VERB bam-12413 7 3 10 10 NUM bam-12413 7 4 patients patient NOUN bam-12413 7 5 ( ( PUNCT bam-12413 7 6 5 5 NUM bam-12413 7 7 female female NOUN bam-12413 7 8 , , PUNCT bam-12413 7 9 5 5 NUM bam-12413 7 10 male male NOUN bam-12413 7 11 ) ) PUNCT bam-12413 7 12 . . PUNCT bam-12413 8 1 treatment treatment NOUN bam-12413 8 2 efficacy efficacy NOUN bam-12413 8 3 was be AUX bam-12413 8 4 assessed assess VERB bam-12413 8 5 through through ADP bam-12413 8 6 the the DET bam-12413 8 7 visual visual ADJ bam-12413 8 8 analogue analogue NOUN bam-12413 8 9 scale scale NOUN bam-12413 8 10 ( ( PUNCT bam-12413 8 11 vas vas NOUN bam-12413 8 12 , , PUNCT bam-12413 8 13 pain pain NOUN bam-12413 8 14 ) ) PUNCT bam-12413 8 15 and and CCONJ bam-12413 8 16 the the DET bam-12413 8 17 knee knee NOUN bam-12413 8 18 injury injury NOUN bam-12413 8 19 and and CCONJ bam-12413 8 20 osteoarthritis osteoarthritis NOUN bam-12413 8 21 outcome outcome NOUN bam-12413 8 22 score score NOUN bam-12413 8 23 ( ( PUNCT bam-12413 8 24 koos koos X bam-12413 8 25 , , PUNCT bam-12413 8 26 knee knee NOUN bam-12413 8 27 function function NOUN bam-12413 8 28 ) ) PUNCT bam-12413 8 29 . . PUNCT bam-12413 9 1 data datum NOUN bam-12413 9 2 are be AUX bam-12413 9 3 acquired acquire VERB bam-12413 9 4 from from ADP bam-12413 9 5 rating rating NOUN bam-12413 9 6 scales scale NOUN bam-12413 9 7 administered administer VERB bam-12413 9 8 at at ADP bam-12413 9 9 the the DET bam-12413 9 10 time time NOUN bam-12413 9 11 of of ADP bam-12413 9 12 injection injection NOUN bam-12413 9 13 ( ( PUNCT bam-12413 9 14 t0 t0 NOUN bam-12413 9 15 ) ) PUNCT bam-12413 9 16 , , PUNCT bam-12413 9 17 one one NUM bam-12413 9 18 month month NOUN bam-12413 9 19 ( ( PUNCT bam-12413 9 20 t1 t1 NOUN bam-12413 9 21 ) ) PUNCT bam-12413 9 22 , , PUNCT bam-12413 9 23 three three NUM bam-12413 9 24 months month NOUN bam-12413 9 25 ( ( PUNCT bam-12413 9 26 t2 t2 NOUN bam-12413 9 27 ) ) PUNCT bam-12413 9 28 , , PUNCT bam-12413 9 29 and and CCONJ bam-12413 9 30 six six NUM bam-12413 9 31 months month NOUN bam-12413 9 32 ( ( PUNCT bam-12413 9 33 t3 t3 PROPN bam-12413 9 34 ) ) PUNCT bam-12413 9 35 after after ADP bam-12413 9 36 treatment treatment NOUN bam-12413 9 37 as as ADP bam-12413 9 38 for for ADP bam-12413 9 39 clinical clinical ADJ bam-12413 9 40 practice practice NOUN bam-12413 9 41 . . PUNCT bam-12413 10 1 results result NOUN bam-12413 10 2 showed show VERB bam-12413 10 3 a a DET bam-12413 10 4 significant significant ADJ bam-12413 10 5 improvement improvement NOUN bam-12413 10 6 in in ADP bam-12413 10 7 pain pain NOUN bam-12413 10 8 and and CCONJ bam-12413 10 9 function function NOUN bam-12413 10 10 at at ADP bam-12413 10 11 t1 t1 PROPN bam-12413 10 12 , , PUNCT bam-12413 10 13 with with ADP bam-12413 10 14 a a DET bam-12413 10 15 subsequent subsequent ADJ bam-12413 10 16 gradual gradual ADJ bam-12413 10 17 resumption resumption NOUN bam-12413 10 18 of of ADP bam-12413 10 19 symptoms symptom NOUN bam-12413 10 20 . . PUNCT bam-12413 11 1 in in ADP bam-12413 11 2 conclusion conclusion NOUN bam-12413 11 3 , , PUNCT bam-12413 11 4 the the DET bam-12413 11 5 treatment treatment NOUN bam-12413 11 6 showed show VERB bam-12413 11 7 a a DET bam-12413 11 8 better well ADJ bam-12413 11 9 outcome outcome NOUN bam-12413 11 10 in in ADP bam-12413 11 11 the the DET bam-12413 11 12 short short ADJ bam-12413 11 13 term term NOUN bam-12413 11 14 ( ( PUNCT bam-12413 11 15 i.e. i.e. X bam-12413 11 16 up up ADP bam-12413 11 17 to to PART bam-12413 11 18 1 1 NUM bam-12413 11 19 month month NOUN bam-12413 11 20 after after ADP bam-12413 11 21 treatment treatment NOUN bam-12413 11 22 ) ) PUNCT bam-12413 11 23 ; ; PUNCT bam-12413 11 24 however however ADV bam-12413 11 25 , , PUNCT bam-12413 11 26 raw raw ADJ bam-12413 11 27 values value NOUN bam-12413 11 28 of of ADP bam-12413 11 29 vas vas X bam-12413 11 30 and and CCONJ bam-12413 11 31 koos koos PROPN bam-12413 11 32 did do AUX bam-12413 11 33 not not PART bam-12413 11 34 return return VERB bam-12413 11 35 to to ADP bam-12413 11 36 baseline baseline NOUN bam-12413 11 37 levels level NOUN bam-12413 11 38 showing show VERB bam-12413 11 39 a a DET bam-12413 11 40 maintenance maintenance NOUN bam-12413 11 41 of of ADP bam-12413 11 42 improvement improvement NOUN bam-12413 11 43 albeit albeit SCONJ bam-12413 11 44 not not PART bam-12413 11 45 statistically statistically ADV bam-12413 11 46 significant significant ADJ bam-12413 11 47 . . PUNCT bam-12413 12 1 key key ADJ bam-12413 12 2 words word NOUN bam-12413 12 3 : : PUNCT bam-12413 12 4 knee knee NOUN bam-12413 12 5 osteoarthritis osteoarthritis NOUN bam-12413 12 6 , , PUNCT bam-12413 12 7 intra intra ADJ bam-12413 12 8 - - ADJ bam-12413 12 9 articular articular ADJ bam-12413 12 10 injections injection NOUN bam-12413 12 11 , , PUNCT bam-12413 12 12 carboxymethyl carboxymethyl NOUN bam-12413 12 13 - - PUNCT bam-12413 12 14 chitosan chitosan ADJ bam-12413 12 15 , , PUNCT bam-12413 12 16 hyaluronic hyaluronic ADJ bam-12413 12 17 acid acid NOUN bam-12413 12 18 , , PUNCT bam-12413 12 19 quality quality NOUN bam-12413 12 20 of of ADP bam-12413 12 21 life life NOUN bam-12413 12 22 . . PUNCT bam-12413 13 1 eur eur PROPN bam-12413 13 2 j j PROPN bam-12413 13 3 transl transl PROPN bam-12413 13 4 myol myol NOUN bam-12413 13 5 34 34 NUM bam-12413 13 6 ( ( PUNCT bam-12413 13 7 3 3 NUM bam-12413 13 8 ) ) PUNCT bam-12413 13 9 12413 12413 NUM bam-12413 13 10 , , PUNCT bam-12413 13 11 2024 2024 NUM bam-12413 13 12 doi doi NOUN bam-12413 13 13 : : PUNCT bam-12413 13 14 10.4081 10.4081 NUM bam-12413 13 15 / / SYM bam-12413 13 16 ejtm.2024.12413 ejtm.2024.12413 PROPN bam-12413 13 17 intra intra ADJ bam-12413 13 18 - - ADJ bam-12413 13 19 articular articular ADJ bam-12413 13 20 injections injection NOUN bam-12413 13 21 with with ADP bam-12413 13 22 carboxymethyl carboxymethyl NOUN bam-12413 13 23 - - PUNCT bam-12413 13 24 chitosan chitosan NOUN bam-12413 13 25 in in ADP bam-12413 13 26 patients patient NOUN bam-12413 13 27 affected affect VERB bam-12413 13 28 by by ADP bam-12413 13 29 knee knee NOUN bam-12413 13 30 osteoarthritis osteoarthritis PROPN bam-12413 13 31 non non NOUN bam-12413 13 32 - - NOUN bam-12413 13 33 responders responder NOUN bam-12413 13 34 to to PART bam-12413 13 35 hyaluronic hyaluronic ADJ bam-12413 13 36 acid acid NOUN bam-12413 13 37 : : PUNCT bam-12413 13 38 a a DET bam-12413 13 39 pilot pilot NOUN bam-12413 13 40 study study NOUN bam-12413 13 41 nicola nicola PROPN bam-12413 13 42 manocchio,1 manocchio,1 PROPN bam-12413 14 1 concetta concetta PROPN bam-12413 14 2 ljoka,1,2 ljoka,1,2 PROPN bam-12413 14 3 nicolò nicolò PROPN bam-12413 14 4 piacentini,1 piacentini,1 X bam-12413 14 5 roberto roberto PROPN bam-12413 14 6 sorge,3 sorge,3 PROPN bam-12413 14 7 giulia giulia PROPN bam-12413 14 8 vita,1 vita,1 NOUN bam-12413 14 9 calogero calogero PROPN bam-12413 14 10 foti1,2 foti1,2 PROPN bam-12413 14 11 1physical 1physical NUM bam-12413 14 12 and and CCONJ bam-12413 14 13 rehabilitation rehabilitation NOUN bam-12413 14 14 medicine medicine NOUN bam-12413 14 15 , , PUNCT bam-12413 14 16 clinical clinical ADJ bam-12413 14 17 sciences science NOUN bam-12413 14 18 and and CCONJ bam-12413 14 19 translational translational ADJ bam-12413 14 20 medicine medicine NOUN bam-12413 14 21 department department PROPN bam-12413 14 22 , , PUNCT bam-12413 14 23 university university PROPN bam-12413 14 24 of of ADP bam-12413 14 25 rome rome PROPN bam-12413 14 26 tor tor PROPN bam-12413 14 27 vergata vergata PROPN bam-12413 14 28 , , PUNCT bam-12413 14 29 italy italy PROPN bam-12413 14 30 ; ; PUNCT bam-12413 14 31 2physical 2physical NUM bam-12413 14 32 and and CCONJ bam-12413 14 33 rehabilitation rehabilitation NOUN bam-12413 14 34 medicine medicine NOUN bam-12413 14 35 unit unit NOUN bam-12413 14 36 , , PUNCT bam-12413 14 37 tor tor PROPN bam-12413 14 38 vergata vergata PROPN bam-12413 14 39 university university NOUN bam-12413 14 40 hospital hospital NOUN bam-12413 14 41 , , PUNCT bam-12413 14 42 rome rome PROPN bam-12413 14 43 , , PUNCT bam-12413 14 44 italy italy PROPN bam-12413 14 45 ; ; PUNCT bam-12413 14 46 3systems 3systems NUM bam-12413 14 47 medicine medicine NOUN bam-12413 14 48 , , PUNCT bam-12413 14 49 biometric biometric ADJ bam-12413 14 50 unit unit NOUN bam-12413 14 51 , , PUNCT bam-12413 14 52 university university PROPN bam-12413 14 53 of of ADP bam-12413 14 54 rome rome PROPN bam-12413 14 55 tor tor PROPN bam-12413 14 56 vergata vergata PROPN bam-12413 14 57 , , PUNCT bam-12413 14 58 italy italy PROPN bam-12413 14 59 . . PUNCT bam-12413 15 1 this this DET bam-12413 15 2 article article NOUN bam-12413 15 3 is be AUX bam-12413 15 4 distributed distribute VERB bam-12413 15 5 under under ADP bam-12413 15 6 the the DET bam-12413 15 7 terms term NOUN bam-12413 15 8 of of ADP bam-12413 15 9 the the DET bam-12413 15 10 creative creative ADJ bam-12413 15 11 commons common NOUN bam-12413 15 12 attribution attribution NOUN bam-12413 15 13 noncommercial noncommercial ADJ bam-12413 15 14 license license NOUN bam-12413 15 15 ( ( PUNCT bam-12413 15 16 cc cc NOUN bam-12413 15 17 by by ADP bam-12413 15 18 - - PUNCT bam-12413 15 19 nc nc PROPN bam-12413 15 20 4.0 4.0 NUM bam-12413 15 21 ) ) PUNCT bam-12413 15 22 which which PRON bam-12413 15 23 permits permit VERB bam-12413 15 24 any any DET bam-12413 15 25 noncommercial noncommercial ADJ bam-12413 15 26 use use NOUN bam-12413 15 27 , , PUNCT bam-12413 15 28 distribution distribution NOUN bam-12413 15 29 , , PUNCT bam-12413 15 30 and and CCONJ bam-12413 15 31 reproduction reproduction NOUN bam-12413 15 32 in in ADP bam-12413 15 33 any any DET bam-12413 15 34 medium medium NOUN bam-12413 15 35 , , PUNCT bam-12413 15 36 provided provide VERB bam-12413 15 37 the the DET bam-12413 15 38 original original ADJ bam-12413 15 39 author(s author(s NOUN bam-12413 15 40 ) ) PUNCT bam-12413 15 41 and and CCONJ bam-12413 15 42 source source NOUN bam-12413 15 43 are be AUX bam-12413 15 44 credited credit VERB bam-12413 15 45 . . PUNCT bam-12413 16 1 31 31 NUM bam-12413 16 2 non non ADJ bam-12413 16 3 -co -co PROPN bam-12413 16 4 mmerc mmerc PROPN bam-12413 16 5 ial ial PROPN bam-12413 16 6 us us PROPN bam-12413 16 7 e e NOUN bam-12413 16 8 o o NOUN bam-12413 16 9 nly nly ADV bam-12413 16 10 intra intra ADJ bam-12413 16 11 - - ADJ bam-12413 16 12 articular articular ADJ bam-12413 16 13 injections injection NOUN bam-12413 16 14 with with ADP bam-12413 16 15 cmc cmc NOUN bam-12413 16 16 in in ADP bam-12413 16 17 patients patient NOUN bam-12413 16 18 affected affect VERB bam-12413 16 19 by by ADP bam-12413 16 20 knee knee NOUN bam-12413 16 21 oa oa PROPN bam-12413 16 22 in in ADP bam-12413 16 23 non non NOUN bam-12413 16 24 - - NOUN bam-12413 16 25 responders responder NOUN bam-12413 16 26 to to PART bam-12413 16 27 hyaluronic hyaluronic VERB bam-12413 16 28 acid acid NOUN bam-12413 16 29 eur eur PROPN bam-12413 16 30 j j PROPN bam-12413 16 31 transl transl PROPN bam-12413 16 32 myol myol NOUN bam-12413 16 33 34 34 NUM bam-12413 16 34 ( ( PUNCT bam-12413 16 35 3 3 NUM bam-12413 16 36 ) ) PUNCT bam-12413 16 37 12413 12413 NUM bam-12413 16 38 , , PUNCT bam-12413 16 39 2024 2024 NUM bam-12413 16 40 doi doi NOUN bam-12413 16 41 : : PUNCT bam-12413 16 42 10.4081 10.4081 NUM bam-12413 16 43 / / SYM bam-12413 16 44 ejtm.2024.12413 ejtm.2024.12413 PROPN bam-12413 16 45 to to PART bam-12413 16 46 reappear reappear VERB bam-12413 16 47 during during ADP bam-12413 16 48 the the DET bam-12413 16 49 day day NOUN bam-12413 16 50 . . PUNCT bam-12413 17 1 morning morning NOUN bam-12413 17 2 stiffness stiffness NOUN bam-12413 17 3 may may AUX bam-12413 17 4 coexist coexist VERB bam-12413 17 5 , , PUNCT bam-12413 17 6 but but CCONJ bam-12413 17 7 it it PRON bam-12413 17 8 is be AUX bam-12413 17 9 usually usually ADV bam-12413 17 10 resolved resolve VERB bam-12413 17 11 with with ADP bam-12413 17 12 joint joint ADJ bam-12413 17 13 mobilization mobilization NOUN bam-12413 17 14 . . PUNCT bam-12413 18 1 pain pain NOUN bam-12413 18 2 is be AUX bam-12413 18 3 associated associate VERB bam-12413 18 4 with with ADP bam-12413 18 5 functional functional ADJ bam-12413 18 6 limitation limitation NOUN bam-12413 18 7 of of ADP bam-12413 18 8 various various ADJ bam-12413 18 9 entities entity NOUN bam-12413 18 10 depending depend VERB bam-12413 18 11 on on ADP bam-12413 18 12 the the DET bam-12413 18 13 stage stage NOUN bam-12413 18 14 of of ADP bam-12413 18 15 the the DET bam-12413 18 16 disease.7 disease.7 NOUN bam-12413 18 17 - - SYM bam-12413 18 18 9 9 NUM bam-12413 18 19 oa oa NOUN bam-12413 18 20 diagnosis diagnosis NOUN bam-12413 18 21 is be AUX bam-12413 18 22 based base VERB bam-12413 18 23 on on ADP bam-12413 18 24 clinical clinical ADJ bam-12413 18 25 detection detection NOUN bam-12413 18 26 of of ADP bam-12413 18 27 pain pain NOUN bam-12413 18 28 , , PUNCT bam-12413 18 29 functional functional ADJ bam-12413 18 30 limitation limitation NOUN bam-12413 18 31 , , PUNCT bam-12413 18 32 bone bone NOUN bam-12413 18 33 swelling swelling NOUN bam-12413 18 34 and and CCONJ bam-12413 18 35 radiographic radiographic ADJ bam-12413 18 36 detection detection NOUN bam-12413 18 37 of of ADP bam-12413 18 38 osteophytes osteophyte NOUN bam-12413 18 39 , , PUNCT bam-12413 18 40 reduction reduction NOUN bam-12413 18 41 of of ADP bam-12413 18 42 joint joint ADJ bam-12413 18 43 interline interline NOUN bam-12413 18 44 and and CCONJ bam-12413 18 45 subchondral subchondral ADJ bam-12413 18 46 sclerosis.10 sclerosis.10 NOUN bam-12413 18 47 nowadays nowadays ADV bam-12413 18 48 there there PRON bam-12413 18 49 is be VERB bam-12413 18 50 no no DET bam-12413 18 51 definitive definitive ADJ bam-12413 18 52 treatment treatment NOUN bam-12413 18 53 for for ADP bam-12413 18 54 oa oa PROPN bam-12413 18 55 but but CCONJ bam-12413 18 56 only only ADV bam-12413 18 57 a a DET bam-12413 18 58 series series NOUN bam-12413 18 59 of of ADP bam-12413 18 60 strategies strategy NOUN bam-12413 18 61 for for ADP bam-12413 18 62 pain pain NOUN bam-12413 18 63 control control NOUN bam-12413 18 64 , , PUNCT bam-12413 18 65 and and CCONJ bam-12413 18 66 improvement improvement NOUN bam-12413 18 67 of of ADP bam-12413 18 68 joint joint ADJ bam-12413 18 69 function function NOUN bam-12413 18 70 and and CCONJ bam-12413 18 71 mobility mobility NOUN bam-12413 18 72 , , PUNCT bam-12413 18 73 to to PART bam-12413 18 74 lead lead VERB bam-12413 18 75 the the DET bam-12413 18 76 patient patient NOUN bam-12413 18 77 to to ADP bam-12413 18 78 the the DET bam-12413 18 79 recovery recovery NOUN bam-12413 18 80 of of ADP bam-12413 18 81 autonomy autonomy NOUN bam-12413 18 82 in in ADP bam-12413 18 83 adl adl PROPN bam-12413 18 84 and and CCONJ bam-12413 18 85 the the DET bam-12413 18 86 improvement improvement NOUN bam-12413 18 87 of of ADP bam-12413 18 88 qol qol NOUN bam-12413 18 89 . . PUNCT bam-12413 19 1 the the DET bam-12413 19 2 pharmacological pharmacological ADJ bam-12413 19 3 approach approach NOUN bam-12413 19 4 mainly mainly ADV bam-12413 19 5 makes make VERB bam-12413 19 6 use use NOUN bam-12413 19 7 of of ADP bam-12413 19 8 nonsteroidal nonsteroidal NOUN bam-12413 19 9 anti anti ADJ bam-12413 19 10 - - ADJ bam-12413 19 11 inflammatory inflammatory ADJ bam-12413 19 12 drugs drug NOUN bam-12413 19 13 ( ( PUNCT bam-12413 19 14 nsaids nsaid NOUN bam-12413 19 15 ) ) PUNCT bam-12413 19 16 , , PUNCT bam-12413 19 17 corticosteroids corticosteroid NOUN bam-12413 19 18 , , PUNCT bam-12413 19 19 additional additional ADJ bam-12413 19 20 analgesics analgesic NOUN bam-12413 19 21 ( ( PUNCT bam-12413 19 22 paracetamol paracetamol NOUN bam-12413 19 23 , , PUNCT bam-12413 19 24 opioids opioid NOUN bam-12413 19 25 ) ) PUNCT bam-12413 19 26 , , PUNCT bam-12413 19 27 and and CCONJ bam-12413 19 28 vis vis X bam-12413 19 29 coinductive coinductive ADJ bam-12413 19 30 / / SYM bam-12413 19 31 viscosupplementary viscosupplementary ADJ bam-12413 19 32 drugs drug NOUN bam-12413 19 33 , , PUNCT bam-12413 19 34 administered administer VERB bam-12413 19 35 orally orally ADV bam-12413 19 36 or or CCONJ bam-12413 19 37 inside inside ADP bam-12413 19 38 the the DET bam-12413 19 39 affected affected ADJ bam-12413 19 40 joints.11 joints.11 ADJ bam-12413 19 41 - - PUNCT bam-12413 19 42 13 13 NUM bam-12413 19 43 chitosan chitosan NOUN bam-12413 19 44 chitosan chitosan NOUN bam-12413 19 45 is be AUX bam-12413 19 46 a a DET bam-12413 19 47 linear linear ADJ bam-12413 19 48 biocompatible biocompatible NOUN bam-12413 19 49 and and CCONJ bam-12413 19 50 biodegradable biodegradable ADJ bam-12413 19 51 polymer polymer NOUN bam-12413 19 52 obtained obtain VERB bam-12413 19 53 from from ADP bam-12413 19 54 the the DET bam-12413 19 55 n n NOUN bam-12413 19 56 - - PUNCT bam-12413 19 57 deacetylation deacetylation NOUN bam-12413 19 58 of of ADP bam-12413 19 59 chitin chitin NOUN bam-12413 19 60 , , PUNCT bam-12413 19 61 with with ADP bam-12413 19 62 mucoadhesive mucoadhesive ADJ bam-12413 19 63 , , PUNCT bam-12413 19 64 antioxidant antioxidant ADJ bam-12413 19 65 , , PUNCT bam-12413 19 66 and and CCONJ bam-12413 19 67 antimicrobial antimicrobial ADJ bam-12413 19 68 properties property NOUN bam-12413 19 69 , , PUNCT bam-12413 19 70 which which PRON bam-12413 19 71 make make VERB bam-12413 19 72 it it PRON bam-12413 19 73 useful useful ADJ bam-12413 19 74 in in ADP bam-12413 19 75 various various ADJ bam-12413 19 76 medical medical ADJ bam-12413 19 77 fields field NOUN bam-12413 19 78 . . PUNCT bam-12413 20 1 due due ADP bam-12413 20 2 to to ADP bam-12413 20 3 its its PRON bam-12413 20 4 physical physical ADJ bam-12413 20 5 , , PUNCT bam-12413 20 6 chemical chemical NOUN bam-12413 20 7 , , PUNCT bam-12413 20 8 and and CCONJ bam-12413 20 9 biological biological ADJ bam-12413 20 10 characteristics characteristic NOUN bam-12413 20 11 , , PUNCT bam-12413 20 12 chitosan chitosan NOUN bam-12413 20 13 and and CCONJ bam-12413 20 14 its its PRON bam-12413 20 15 derivatives derivative NOUN bam-12413 20 16 have have AUX bam-12413 20 17 been be AUX bam-12413 20 18 extensively extensively ADV bam-12413 20 19 studied study VERB bam-12413 20 20 for for ADP bam-12413 20 21 many many ADJ bam-12413 20 22 medical medical ADJ bam-12413 20 23 applications application NOUN bam-12413 20 24 , , PUNCT bam-12413 20 25 including include VERB bam-12413 20 26 wound wound NOUN bam-12413 20 27 healing healing NOUN bam-12413 20 28 , , PUNCT bam-12413 20 29 drug drug NOUN bam-12413 20 30 administration administration NOUN bam-12413 20 31 , , PUNCT bam-12413 20 32 and and CCONJ bam-12413 20 33 tissue tissue NOUN bam-12413 20 34 engineering.14 engineering.14 NOUN bam-12413 20 35 - - PUNCT bam-12413 20 36 19 19 NUM bam-12413 20 37 various various ADJ bam-12413 20 38 studies study NOUN bam-12413 20 39 conducted conduct VERB bam-12413 20 40 in in ADP bam-12413 20 41 vitro vitro X bam-12413 20 42 and and CCONJ bam-12413 20 43 ex ex PRON bam-12413 20 44 vivo vivo NOUN bam-12413 20 45 have have AUX bam-12413 20 46 shown show VERB bam-12413 20 47 that that SCONJ bam-12413 20 48 intra intra ADJ bam-12413 20 49 - - ADJ bam-12413 20 50 articular articular ADJ bam-12413 20 51 administration administration NOUN bam-12413 20 52 of of ADP bam-12413 20 53 this this DET bam-12413 20 54 polymer polymer NOUN bam-12413 20 55 could could AUX bam-12413 20 56 prevent prevent VERB bam-12413 20 57 the the DET bam-12413 20 58 degradation degradation NOUN bam-12413 20 59 of of ADP bam-12413 20 60 articular articular ADJ bam-12413 20 61 cartilage cartilage NOUN bam-12413 20 62 , , PUNCT bam-12413 20 63 inducing induce VERB bam-12413 20 64 chondrogenic chondrogenic ADJ bam-12413 20 65 differentiation differentiation NOUN bam-12413 20 66 of of ADP bam-12413 20 67 mesenchymal mesenchymal ADJ bam-12413 20 68 stem stem NOUN bam-12413 20 69 cells cell NOUN bam-12413 20 70 , , PUNCT bam-12413 20 71 triggering trigger VERB bam-12413 20 72 the the DET bam-12413 20 73 production production NOUN bam-12413 20 74 of of ADP bam-12413 20 75 type type NOUN bam-12413 20 76 i i PROPN bam-12413 20 77 and and CCONJ bam-12413 20 78 ii ii PROPN bam-12413 20 79 collagen collagen NOUN bam-12413 20 80 and and CCONJ bam-12413 20 81 reducing reduce VERB bam-12413 20 82 the the DET bam-12413 20 83 production production NOUN bam-12413 20 84 of of ADP bam-12413 20 85 inflammatory inflammatory ADJ bam-12413 20 86 and and CCONJ bam-12413 20 87 catabolic catabolic ADJ bam-12413 20 88 mediators mediator NOUN bam-12413 20 89 by by ADP bam-12413 20 90 chondrocytes.15,20 chondrocytes.15,20 NOUN bam-12413 20 91 - - PUNCT bam-12413 20 92 22 22 NUM bam-12413 20 93 the the DET bam-12413 20 94 carboxylated carboxylate VERB bam-12413 20 95 and and CCONJ bam-12413 20 96 methylated methylate VERB bam-12413 20 97 form form NOUN bam-12413 20 98 of of ADP bam-12413 20 99 chitosan chitosan NOUN bam-12413 20 100 ( ( PUNCT bam-12413 20 101 carboxymethyl carboxymethyl NOUN bam-12413 20 102 - - PUNCT bam-12413 20 103 chitosan chitosan NOUN bam-12413 20 104 , , PUNCT bam-12413 20 105 cm cm NOUN bam-12413 20 106 - - PUNCT bam-12413 20 107 c c NOUN bam-12413 20 108 ) ) PUNCT bam-12413 20 109 is be AUX bam-12413 20 110 extracted extract VERB bam-12413 20 111 from from ADP bam-12413 20 112 the the DET bam-12413 20 113 fungus fungus NOUN bam-12413 20 114 agaricus agaricus NOUN bam-12413 20 115 bisporus bisporus NOUN bam-12413 20 116 . . PUNCT bam-12413 21 1 if if SCONJ bam-12413 21 2 applied apply VERB bam-12413 21 3 to to ADP bam-12413 21 4 the the DET bam-12413 21 5 biological biological ADJ bam-12413 21 6 tissue tissue NOUN bam-12413 21 7 , , PUNCT bam-12413 21 8 the the DET bam-12413 21 9 degradation degradation NOUN bam-12413 21 10 of of ADP bam-12413 21 11 cm cm NOUN bam-12413 21 12 - - PUNCT bam-12413 21 13 c c NOUN bam-12413 21 14 occurs occur VERB bam-12413 21 15 through through ADP bam-12413 21 16 a a DET bam-12413 21 17 physiological physiological ADJ bam-12413 21 18 macrophage macrophage ADJ bam-12413 21 19 reabsorption reabsorption NOUN bam-12413 21 20 process process NOUN bam-12413 21 21 , , PUNCT bam-12413 21 22 in in ADP bam-12413 21 23 which which PRON bam-12413 21 24 granuloma granuloma ADJ bam-12413 21 25 formation formation NOUN bam-12413 21 26 has have AUX bam-12413 21 27 not not PART bam-12413 21 28 been be AUX bam-12413 21 29 observed observe VERB bam-12413 21 30 and and CCONJ bam-12413 21 31 no no DET bam-12413 21 32 cytotoxic cytotoxic ADJ bam-12413 21 33 potentials potential NOUN bam-12413 21 34 have have AUX bam-12413 21 35 been be AUX bam-12413 21 36 demonstrated demonstrate VERB bam-12413 21 37 in in ADP bam-12413 21 38 vivo vivo NOUN bam-12413 21 39 . . PUNCT bam-12413 22 1 however however ADV bam-12413 22 2 , , PUNCT bam-12413 22 3 macrophage macrophage ADJ bam-12413 22 4 activation activation NOUN bam-12413 22 5 may may AUX bam-12413 22 6 present present VERB bam-12413 22 7 with with ADP bam-12413 22 8 a a DET bam-12413 22 9 transient transient ADJ bam-12413 22 10 and and CCONJ bam-12413 22 11 reversible reversible ADJ bam-12413 22 12 post post ADJ bam-12413 22 13 - - ADJ bam-12413 22 14 injection injection ADJ bam-12413 22 15 inflammatory inflammatory ADJ bam-12413 22 16 reaction reaction NOUN bam-12413 22 17 that that PRON bam-12413 22 18 responds respond VERB bam-12413 22 19 well well ADV bam-12413 22 20 to to ADP bam-12413 22 21 treatment treatment VERB bam-12413 22 22 with with ADP bam-12413 22 23 oral oral ADJ bam-12413 22 24 nsaids.23 nsaids.23 PROPN bam-12413 22 25 experimental experimental ADJ bam-12413 22 26 studies study NOUN bam-12413 22 27 conducted conduct VERB bam-12413 22 28 on on ADP bam-12413 22 29 intra intra ADJ bam-12413 22 30 - - ADJ bam-12413 22 31 articular articular ADJ bam-12413 22 32 administration administration NOUN bam-12413 22 33 of of ADP bam-12413 22 34 this this DET bam-12413 22 35 macromolecule macromolecule NOUN bam-12413 22 36 in in ADP bam-12413 22 37 animal animal NOUN bam-12413 22 38 models model NOUN bam-12413 22 39 have have AUX bam-12413 22 40 shown show VERB bam-12413 22 41 a a DET bam-12413 22 42 low low ADJ bam-12413 22 43 incidence incidence NOUN bam-12413 22 44 of of ADP bam-12413 22 45 post post ADJ bam-12413 22 46 - - ADJ bam-12413 22 47 administration administration ADJ bam-12413 22 48 side side NOUN bam-12413 22 49 effects effect NOUN bam-12413 22 50 , , PUNCT bam-12413 22 51 limited limit VERB bam-12413 22 52 to to PART bam-12413 22 53 minimal minimal VERB bam-12413 22 54 local local ADJ bam-12413 22 55 tissue tissue NOUN bam-12413 22 56 reactions.23,24 reactions.23,24 VERB bam-12413 22 57 further further ADJ bam-12413 22 58 studies study NOUN bam-12413 22 59 recently recently ADV bam-12413 22 60 conducted conduct VERB bam-12413 22 61 in in ADP bam-12413 22 62 vitro vitro X bam-12413 22 63 and and CCONJ bam-12413 22 64 ex ex NOUN bam-12413 22 65 - - ADJ bam-12413 22 66 vivo vivo NOUN bam-12413 22 67 found find VERB bam-12413 22 68 a a DET bam-12413 22 69 higher high ADJ bam-12413 22 70 lubricating lubricating NOUN bam-12413 22 71 capacity capacity NOUN bam-12413 22 72 by by ADP bam-12413 22 73 cmc cmc PROPN bam-12413 22 74 , , PUNCT bam-12413 22 75 with with ADP bam-12413 22 76 a a DET bam-12413 22 77 significant significant ADJ bam-12413 22 78 reduction reduction NOUN bam-12413 22 79 in in ADP bam-12413 22 80 coefficient coefficient NOUN bam-12413 22 81 of of ADP bam-12413 22 82 friction friction NOUN bam-12413 22 83 , , PUNCT bam-12413 22 84 compared compare VERB bam-12413 22 85 to to ADP bam-12413 22 86 traditional traditional ADJ bam-12413 22 87 formulations formulation NOUN bam-12413 22 88 of of ADP bam-12413 22 89 cross cross ADJ bam-12413 22 90 - - ADJ bam-12413 22 91 linked link VERB bam-12413 22 92 hyaluronic hyaluronic ADJ bam-12413 22 93 acid acid NOUN bam-12413 22 94 ( ( PUNCT bam-12413 22 95 ha ha INTJ bam-12413 22 96 ) ) PUNCT bam-12413 22 97 , , PUNCT bam-12413 22 98 with with ADP bam-12413 22 99 a a DET bam-12413 22 100 more more ADV bam-12413 22 101 significant significant ADJ bam-12413 22 102 recovery recovery NOUN bam-12413 22 103 of of ADP bam-12413 22 104 joint joint ADJ bam-12413 22 105 mobility.25,26 mobility.25,26 NOUN bam-12413 22 106 aim aim VERB bam-12413 22 107 this this DET bam-12413 22 108 study study NOUN bam-12413 22 109 aims aim VERB bam-12413 22 110 to to PART bam-12413 22 111 evaluate evaluate VERB bam-12413 22 112 the the DET bam-12413 22 113 efficacy efficacy NOUN bam-12413 22 114 of of ADP bam-12413 22 115 a a DET bam-12413 22 116 single single ADJ bam-12413 22 117 intraarticular intraarticular ADJ bam-12413 22 118 knee knee NOUN bam-12413 22 119 injection injection NOUN bam-12413 22 120 with with ADP bam-12413 22 121 cm cm NOUN bam-12413 22 122 - - PUNCT bam-12413 22 123 c c NOUN bam-12413 22 124 in in ADP bam-12413 22 125 non non NOUN bam-12413 22 126 - - NOUN bam-12413 22 127 responders responder NOUN bam-12413 22 128 to to PART bam-12413 22 129 ha ha INTJ bam-12413 22 130 with with ADP bam-12413 22 131 advanced advanced ADJ bam-12413 22 132 oa oa X bam-12413 22 133 ( ( PUNCT bam-12413 22 134 kl≥3 kl≥3 PROPN bam-12413 22 135 ) ) PUNCT bam-12413 22 136 on on ADP bam-12413 22 137 pain pain NOUN bam-12413 22 138 and and CCONJ bam-12413 22 139 functional functional ADJ bam-12413 22 140 outcomes outcome NOUN bam-12413 22 141 . . PUNCT bam-12413 23 1 materials material NOUN bam-12413 23 2 and and CCONJ bam-12413 23 3 methods method NOUN bam-12413 23 4 the the DET bam-12413 23 5 study study NOUN bam-12413 23 6 has have VERB bam-12413 23 7 a a DET bam-12413 23 8 retrospective retrospective ADJ bam-12413 23 9 design design NOUN bam-12413 23 10 . . PUNCT bam-12413 24 1 data datum NOUN bam-12413 24 2 were be AUX bam-12413 24 3 collected collect VERB bam-12413 24 4 from from ADP bam-12413 24 5 patients patient NOUN bam-12413 24 6 attending attend VERB bam-12413 24 7 the the DET bam-12413 24 8 physical physical ADJ bam-12413 24 9 medicine medicine NOUN bam-12413 24 10 and and CCONJ bam-12413 24 11 rehabilitation rehabilitation NOUN bam-12413 24 12 outpatient outpatient NOUN bam-12413 24 13 clinic clinic NOUN bam-12413 24 14 at at ADP bam-12413 24 15 the the DET bam-12413 24 16 tor tor PROPN bam-12413 24 17 vergata vergata PROPN bam-12413 24 18 university university NOUN bam-12413 24 19 hospital hospital NOUN bam-12413 24 20 , , PUNCT bam-12413 24 21 rome rome PROPN bam-12413 24 22 . . PUNCT bam-12413 25 1 the the DET bam-12413 25 2 study study NOUN bam-12413 25 3 analyzed analyze VERB bam-12413 25 4 data datum NOUN bam-12413 25 5 from from ADP bam-12413 25 6 patients patient NOUN bam-12413 25 7 treated treat VERB bam-12413 25 8 with with ADP bam-12413 25 9 intra intra ADJ bam-12413 25 10 - - ADJ bam-12413 25 11 articular articular ADJ bam-12413 25 12 cm cm NOUN bam-12413 25 13 - - PUNCT bam-12413 25 14 c c NOUN bam-12413 25 15 ( ( PUNCT bam-12413 25 16 a a DET bam-12413 25 17 compound compound NOUN bam-12413 25 18 of of ADP bam-12413 25 19 cm cm NOUN bam-12413 25 20 - - PUNCT bam-12413 25 21 c c NOUN bam-12413 25 22 ( ( PUNCT bam-12413 25 23 60 60 NUM bam-12413 25 24 mg/3 mg/3 PROPN bam-12413 25 25 ml ml NOUN bam-12413 25 26 ) ) PUNCT bam-12413 25 27 consisting consist VERB bam-12413 25 28 of of ADP bam-12413 25 29 2 2 NUM bam-12413 25 30 % % NOUN bam-12413 25 31 ( ( PUNCT bam-12413 25 32 w w NOUN bam-12413 25 33 / / SYM bam-12413 25 34 w w NOUN bam-12413 25 35 ) ) PUNCT bam-12413 25 36 cm cm NOUN bam-12413 25 37 - - PUNCT bam-12413 25 38 c c NOUN bam-12413 25 39 in in ADP bam-12413 25 40 phosphate phosphate ADJ bam-12413 25 41 buffer buffer NOUN bam-12413 25 42 supplemented supplement VERB bam-12413 25 43 with with ADP bam-12413 25 44 3.5 3.5 NUM bam-12413 25 45 % % NOUN bam-12413 25 46 sorbitol sorbitol NOUN bam-12413 25 47 ) ) PUNCT bam-12413 25 48 who who PRON bam-12413 25 49 met meet VERB bam-12413 25 50 the the DET bam-12413 25 51 inclusion inclusion NOUN bam-12413 25 52 criteria criterion NOUN bam-12413 25 53 within within ADP bam-12413 25 54 the the DET bam-12413 25 55 period period NOUN bam-12413 25 56 from from ADP bam-12413 25 57 september september PROPN bam-12413 25 58 2022 2022 NUM bam-12413 25 59 to to ADP bam-12413 25 60 october october PROPN bam-12413 25 61 2023 2023 NUM bam-12413 25 62 . . PUNCT bam-12413 26 1 data datum NOUN bam-12413 26 2 were be AUX bam-12413 26 3 acquired acquire VERB bam-12413 26 4 from from ADP bam-12413 26 5 rating rating NOUN bam-12413 26 6 scales scale NOUN bam-12413 26 7 administered administer VERB bam-12413 26 8 by by ADP bam-12413 26 9 a a DET bam-12413 26 10 physiatrist physiatrist NOUN bam-12413 26 11 with with ADP bam-12413 26 12 several several ADJ bam-12413 26 13 years year NOUN bam-12413 26 14 of of ADP bam-12413 26 15 experience experience NOUN bam-12413 26 16 in in ADP bam-12413 26 17 knee knee NOUN bam-12413 26 18 oa oa NOUN bam-12413 26 19 and and CCONJ bam-12413 26 20 injection injection NOUN bam-12413 26 21 therapy therapy NOUN bam-12413 26 22 at at ADP bam-12413 26 23 the the DET bam-12413 26 24 time time NOUN bam-12413 26 25 of of ADP bam-12413 26 26 injection injection NOUN bam-12413 26 27 ( ( PUNCT bam-12413 26 28 t0 t0 NOUN bam-12413 26 29 ) ) PUNCT bam-12413 26 30 , , PUNCT bam-12413 26 31 one one NUM bam-12413 26 32 month month NOUN bam-12413 26 33 ( ( PUNCT bam-12413 26 34 t1 t1 NOUN bam-12413 26 35 ) ) PUNCT bam-12413 26 36 , , PUNCT bam-12413 26 37 three three NUM bam-12413 26 38 months month NOUN bam-12413 26 39 ( ( PUNCT bam-12413 26 40 t2 t2 NOUN bam-12413 26 41 ) ) PUNCT bam-12413 26 42 , , PUNCT bam-12413 26 43 and and CCONJ bam-12413 26 44 six six NUM bam-12413 26 45 months month NOUN bam-12413 26 46 ( ( PUNCT bam-12413 26 47 t3 t3 PROPN bam-12413 26 48 ) ) PUNCT bam-12413 26 49 after after ADP bam-12413 26 50 treatment treatment NOUN bam-12413 26 51 as as ADP bam-12413 26 52 for for ADP bam-12413 26 53 clinical clinical ADJ bam-12413 26 54 practice practice NOUN bam-12413 26 55 . . PUNCT bam-12413 27 1 the the DET bam-12413 27 2 clinical clinical ADJ bam-12413 27 3 protocol protocol NOUN bam-12413 27 4 was be AUX bam-12413 27 5 conducted conduct VERB bam-12413 27 6 , , PUNCT bam-12413 27 7 recorded record VERB bam-12413 27 8 , , PUNCT bam-12413 27 9 and and CCONJ bam-12413 27 10 reported report VERB bam-12413 27 11 by by ADP bam-12413 27 12 good good ADJ bam-12413 27 13 clinical clinical ADJ bam-12413 27 14 practice practice NOUN bam-12413 27 15 guidelines guideline NOUN bam-12413 27 16 and and CCONJ bam-12413 27 17 the the DET bam-12413 27 18 declaration declaration NOUN bam-12413 27 19 of of ADP bam-12413 27 20 helsinki helsinki PROPN bam-12413 27 21 and and CCONJ bam-12413 27 22 approved approve VERB bam-12413 27 23 by by ADP bam-12413 27 24 the the DET bam-12413 27 25 the the DET bam-12413 27 26 territorial territorial ADJ bam-12413 27 27 ethics ethic NOUN bam-12413 27 28 committee committee PROPN bam-12413 27 29 “ " PUNCT bam-12413 27 30 lazio lazio PROPN bam-12413 27 31 area area NOUN bam-12413 27 32 2 2 NUM bam-12413 27 33 ” " PUNCT bam-12413 27 34 ( ( PUNCT bam-12413 27 35 173.24 173.24 NUM bam-12413 27 36 ) ) PUNCT bam-12413 27 37 . . PUNCT bam-12413 28 1 before before ADP bam-12413 28 2 collecting collect VERB bam-12413 28 3 the the DET bam-12413 28 4 data datum NOUN bam-12413 28 5 , , PUNCT bam-12413 28 6 an an DET bam-12413 28 7 informed informed ADJ bam-12413 28 8 consent consent NOUN bam-12413 28 9 form form NOUN bam-12413 28 10 was be AUX bam-12413 28 11 signed sign VERB bam-12413 28 12 by by ADP bam-12413 28 13 all all DET bam-12413 28 14 the the DET bam-12413 28 15 participants.27 participants.27 PROPN bam-12413 28 16 inclusion inclusion NOUN bam-12413 28 17 and and CCONJ bam-12413 28 18 exclusion exclusion NOUN bam-12413 28 19 criteria criterion NOUN bam-12413 28 20 subjects subject NOUN bam-12413 28 21 were be AUX bam-12413 28 22 enrolled enrol VERB bam-12413 28 23 according accord VERB bam-12413 28 24 to to ADP bam-12413 28 25 the the DET bam-12413 28 26 following follow VERB bam-12413 28 27 criteria criterion NOUN bam-12413 28 28 . . PUNCT bam-12413 29 1 inclusion inclusion NOUN bam-12413 29 2 criteria criterion NOUN bam-12413 29 3 : : PUNCT bam-12413 29 4 i i NOUN bam-12413 29 5 ) ) PUNCT bam-12413 29 6 male male ADJ bam-12413 29 7 and and CCONJ bam-12413 29 8 female female ADJ bam-12413 29 9 patients patient NOUN bam-12413 29 10 of of ADP bam-12413 29 11 all all DET bam-12413 29 12 ages age NOUN bam-12413 29 13 with with ADP bam-12413 29 14 advanced advanced ADJ bam-12413 29 15 and and CCONJ bam-12413 29 16 symptomatic symptomatic ADJ bam-12413 29 17 gonarthrosis gonarthrosis NOUN bam-12413 29 18 [ [ X bam-12413 29 19 radiographic radiographic ADJ bam-12413 29 20 kellgren kellgren NOUN bam-12413 29 21 - - PUNCT bam-12413 29 22 lawrence lawrence PROPN bam-12413 29 23 ( ( PUNCT bam-12413 29 24 kl kl NOUN bam-12413 29 25 ) ) PUNCT bam-12413 29 26 grade grade NOUN bam-12413 29 27 ≥ ≥ PROPN bam-12413 29 28 3];28 3];28 NUM bam-12413 29 29 ii ii NOUN bam-12413 29 30 ) ) PUNCT bam-12413 29 31 patients patient NOUN bam-12413 29 32 previously previously ADV bam-12413 29 33 unsuccessfully unsuccessfully ADV bam-12413 29 34 treated treat VERB bam-12413 29 35 with with ADP bam-12413 29 36 intra intra ADJ bam-12413 29 37 - - ADJ bam-12413 29 38 articular articular ADJ bam-12413 29 39 ha ha INTJ bam-12413 29 40 injections injection NOUN bam-12413 29 41 in in ADP bam-12413 29 42 the the DET bam-12413 29 43 knee knee NOUN bam-12413 29 44 and and CCONJ bam-12413 29 45 subsequently subsequently ADV bam-12413 29 46 treated treat VERB bam-12413 29 47 at at ADP bam-12413 29 48 the the DET bam-12413 29 49 same same ADJ bam-12413 29 50 level level NOUN bam-12413 29 51 with with ADP bam-12413 29 52 cm cm NOUN bam-12413 29 53 - - PUNCT bam-12413 29 54 c c NOUN bam-12413 29 55 ; ; PUNCT bam-12413 29 56 iii iii X bam-12413 29 57 ) ) PUNCT bam-12413 29 58 patients patient NOUN bam-12413 29 59 with with ADP bam-12413 29 60 a a DET bam-12413 29 61 minimum minimum ADJ bam-12413 29 62 6 6 NUM bam-12413 29 63 - - PUNCT bam-12413 29 64 month month NOUN bam-12413 29 65 follow follow NOUN bam-12413 29 66 - - PUNCT bam-12413 29 67 up up NOUN bam-12413 29 68 who who PRON bam-12413 29 69 underwent undergo VERB bam-12413 29 70 scheduled schedule VERB bam-12413 29 71 clinical clinical ADJ bam-12413 29 72 assessments assessment NOUN bam-12413 29 73 at at ADP bam-12413 29 74 1 1 NUM bam-12413 29 75 , , PUNCT bam-12413 29 76 3 3 NUM bam-12413 29 77 , , PUNCT bam-12413 29 78 and and CCONJ bam-12413 29 79 6 6 NUM bam-12413 29 80 months month NOUN bam-12413 29 81 . . PUNCT bam-12413 30 1 exclusion exclusion NOUN bam-12413 30 2 criteria criterion NOUN bam-12413 30 3 : : PUNCT bam-12413 31 1 i i PRON bam-12413 31 2 ) ) PUNCT bam-12413 31 3 patients patient NOUN bam-12413 31 4 not not PART bam-12413 31 5 treated treat VERB bam-12413 31 6 with with ADP bam-12413 31 7 cm cm NOUN bam-12413 31 8 - - PUNCT bam-12413 31 9 c c PROPN bam-12413 31 10 ; ; PUNCT bam-12413 31 11 ii ii X bam-12413 31 12 ) ) PUNCT bam-12413 31 13 patients patient NOUN bam-12413 31 14 for for ADP bam-12413 31 15 whom whom PRON bam-12413 31 16 koos koo NOUN bam-12413 31 17 and and CCONJ bam-12413 31 18 vas vas X bam-12413 31 19 were be AUX bam-12413 31 20 not not PART bam-12413 31 21 completed complete VERB bam-12413 31 22 . . PUNCT bam-12413 32 1 rating rating NOUN bam-12413 32 2 scales scale NOUN bam-12413 32 3 for for ADP bam-12413 32 4 this this DET bam-12413 32 5 study study NOUN bam-12413 32 6 , , PUNCT bam-12413 32 7 two two NUM bam-12413 32 8 rating rating NOUN bam-12413 32 9 scales scale NOUN bam-12413 32 10 were be AUX bam-12413 32 11 considered consider VERB bam-12413 32 12 : : PUNCT bam-12413 32 13 the the DET bam-12413 32 14 visual visual ADJ bam-12413 32 15 analogue analogue NOUN bam-12413 32 16 scale scale NOUN bam-12413 32 17 ( ( PUNCT bam-12413 32 18 vas vas NOUN bam-12413 32 19 ) ) PUNCT bam-12413 32 20 for for ADP bam-12413 32 21 pain pain NOUN bam-12413 32 22 measurement measurement NOUN bam-12413 32 23 and and CCONJ bam-12413 32 24 the the DET bam-12413 32 25 knee knee NOUN bam-12413 32 26 injury injury NOUN bam-12413 32 27 and and CCONJ bam-12413 32 28 osteoarthritis osteoarthritis NOUN bam-12413 32 29 outcome outcome NOUN bam-12413 32 30 score score NOUN bam-12413 32 31 ( ( PUNCT bam-12413 32 32 koos koos PROPN bam-12413 32 33 ) ) PUNCT bam-12413 32 34 as as ADP bam-12413 32 35 a a DET bam-12413 32 36 functional functional ADJ bam-12413 32 37 outcome outcome NOUN bam-12413 32 38 . . PUNCT bam-12413 33 1 vas vas X bam-12413 33 2 is be AUX bam-12413 33 3 a a DET bam-12413 33 4 pain pain NOUN bam-12413 33 5 rating rating NOUN bam-12413 33 6 scale scale NOUN bam-12413 33 7 developed develop VERB bam-12413 33 8 by by ADP bam-12413 33 9 scott scott PROPN bam-12413 33 10 and and CCONJ bam-12413 33 11 huskisson29 huskisson29 NOUN bam-12413 33 12 that that PRON bam-12413 33 13 consists consist VERB bam-12413 33 14 of of ADP bam-12413 33 15 a a DET bam-12413 33 16 straight straight ADJ bam-12413 33 17 line line NOUN bam-12413 33 18 , , PUNCT bam-12413 33 19 generally generally ADV bam-12413 33 20 100 100 NUM bam-12413 33 21 mm mm NOUN bam-12413 33 22 long long ADV bam-12413 33 23 , , PUNCT bam-12413 33 24 at at ADP bam-12413 33 25 the the DET bam-12413 33 26 extremes extreme NOUN bam-12413 33 27 of of ADP bam-12413 33 28 which which PRON bam-12413 33 29 it it PRON bam-12413 33 30 is be AUX bam-12413 33 31 possible possible ADJ bam-12413 33 32 to to PART bam-12413 33 33 read read VERB bam-12413 33 34 the the DET bam-12413 33 35 indications indication NOUN bam-12413 33 36 “ " PUNCT bam-12413 33 37 absence absence NOUN bam-12413 33 38 of of ADP bam-12413 33 39 pain pain NOUN bam-12413 33 40 ” " PUNCT bam-12413 33 41 and and CCONJ bam-12413 33 42 “ " PUNCT bam-12413 33 43 maximum maximum ADJ bam-12413 33 44 pain pain NOUN bam-12413 33 45 ” " PUNCT bam-12413 33 46 . . PUNCT bam-12413 34 1 the the DET bam-12413 34 2 patient patient NOUN bam-12413 34 3 has have VERB bam-12413 34 4 to to PART bam-12413 34 5 self self NOUN bam-12413 34 6 - - PUNCT bam-12413 34 7 report report NOUN bam-12413 34 8 pain pain NOUN bam-12413 34 9 intensity intensity NOUN bam-12413 34 10 by by ADP bam-12413 34 11 placing place VERB bam-12413 34 12 a a DET bam-12413 34 13 sign sign NOUN bam-12413 34 14 according accord VERB bam-12413 34 15 to to ADP bam-12413 34 16 his his PRON bam-12413 34 17 or or CCONJ bam-12413 34 18 her her PRON bam-12413 34 19 current current ADJ bam-12413 34 20 pain pain NOUN bam-12413 34 21 level level NOUN bam-12413 34 22 . . PUNCT bam-12413 35 1 the the DET bam-12413 35 2 proximity proximity NOUN bam-12413 35 3 of of ADP bam-12413 35 4 the the DET bam-12413 35 5 sign sign NOUN bam-12413 35 6 to to ADP bam-12413 35 7 one one NUM bam-12413 35 8 of of ADP bam-12413 35 9 the the DET bam-12413 35 10 two two NUM bam-12413 35 11 extremities extremity NOUN bam-12413 35 12 indicates indicate VERB bam-12413 35 13 more more ADJ bam-12413 35 14 or or CCONJ bam-12413 35 15 less less ADV bam-12413 35 16 intense intense ADJ bam-12413 35 17 pain pain NOUN bam-12413 35 18 . . PUNCT bam-12413 36 1 koos koos PROPN bam-12413 36 2 is be AUX bam-12413 36 3 a a DET bam-12413 36 4 self self NOUN bam-12413 36 5 - - PUNCT bam-12413 36 6 administered administer VERB bam-12413 36 7 questionnaire questionnaire NOUN bam-12413 36 8 that that PRON bam-12413 36 9 aims aim VERB bam-12413 36 10 to to PART bam-12413 36 11 assess assess VERB bam-12413 36 12 the the DET bam-12413 36 13 reported report VERB bam-12413 36 14 symptoms symptom NOUN bam-12413 36 15 in in ADP bam-12413 36 16 the the DET bam-12413 36 17 knee knee NOUN bam-12413 36 18 joint.30 joint.30 VERB bam-12413 36 19 the the DET bam-12413 36 20 scale scale NOUN bam-12413 36 21 consists consist VERB bam-12413 36 22 of of ADP bam-12413 36 23 42 42 NUM bam-12413 36 24 items item NOUN bam-12413 36 25 and and CCONJ bam-12413 36 26 5 5 NUM bam-12413 36 27 domains domain NOUN bam-12413 36 28 that that PRON bam-12413 36 29 respectively respectively ADV bam-12413 36 30 assess assess VERB bam-12413 36 31 symptoms symptom NOUN bam-12413 36 32 , , PUNCT bam-12413 36 33 pain pain NOUN bam-12413 36 34 , , PUNCT bam-12413 36 35 adl adl PROPN bam-12413 36 36 , , PUNCT bam-12413 36 37 sports sport NOUN bam-12413 36 38 and and CCONJ bam-12413 36 39 recreational recreational ADJ bam-12413 36 40 activities activity NOUN bam-12413 36 41 , , PUNCT bam-12413 36 42 and and CCONJ bam-12413 36 43 qol qol X bam-12413 36 44 . . PUNCT bam-12413 37 1 all all DET bam-12413 37 2 items item NOUN bam-12413 37 3 on on ADP bam-12413 37 4 the the DET bam-12413 37 5 scale scale NOUN bam-12413 37 6 have have VERB bam-12413 37 7 the the DET bam-12413 37 8 same same ADJ bam-12413 37 9 response response NOUN bam-12413 37 10 mode mode NOUN bam-12413 37 11 , , PUNCT bam-12413 37 12 using use VERB bam-12413 37 13 a a DET bam-12413 37 14 5 5 NUM bam-12413 37 15 - - PUNCT bam-12413 37 16 point point NOUN bam-12413 37 17 likert likert ADJ bam-12413 37 18 scale scale NOUN bam-12413 37 19 ranging range VERB bam-12413 37 20 from from ADP bam-12413 37 21 0 0 NUM bam-12413 37 22 ( ( PUNCT bam-12413 37 23 no no DET bam-12413 37 24 problems problem NOUN bam-12413 37 25 or or CCONJ bam-12413 37 26 difficulties difficulty NOUN bam-12413 37 27 ) ) PUNCT bam-12413 37 28 to to ADP bam-12413 37 29 4 4 NUM bam-12413 37 30 ( ( PUNCT bam-12413 37 31 problems problem NOUN bam-12413 37 32 or or CCONJ bam-12413 37 33 high high ADJ bam-12413 37 34 difficulties difficulty NOUN bam-12413 37 35 ) ) PUNCT bam-12413 37 36 . . PUNCT bam-12413 38 1 the the DET bam-12413 38 2 results result NOUN bam-12413 38 3 of of ADP bam-12413 38 4 each each DET bam-12413 38 5 subscale subscale NOUN bam-12413 38 6 are be AUX bam-12413 38 7 calculated calculate VERB bam-12413 38 8 separately separately ADV bam-12413 38 9 using use VERB bam-12413 38 10 the the DET bam-12413 38 11 formula formula NOUN bam-12413 38 12 : : PUNCT bam-12413 38 13 100 100 NUM bam-12413 38 14 − − NOUN bam-12413 38 15 ( ( PUNCT bam-12413 38 16 score score NOUN bam-12413 38 17 obtained obtain VERB bam-12413 38 18 x x PROPN bam-12413 38 19 100 100 NUM bam-12413 38 20 ) ) PUNCT bam-12413 38 21 / / SYM bam-12413 38 22 ( ( PUNCT bam-12413 38 23 maximum maximum ADJ bam-12413 38 24 score score NOUN bam-12413 38 25 ) ) PUNCT bam-12413 38 26 the the DET bam-12413 38 27 score score NOUN bam-12413 38 28 will will AUX bam-12413 38 29 then then ADV bam-12413 38 30 be be AUX bam-12413 38 31 expressed express VERB bam-12413 38 32 as as ADP bam-12413 38 33 a a DET bam-12413 38 34 percentage percentage NOUN bam-12413 38 35 for for ADP bam-12413 38 36 each each DET bam-12413 38 37 subscale subscale NOUN bam-12413 38 38 , , PUNCT bam-12413 38 39 ranging range VERB bam-12413 38 40 from from ADP bam-12413 38 41 0 0 NUM bam-12413 38 42 ( ( PUNCT bam-12413 38 43 condition condition NOUN bam-12413 38 44 of of ADP bam-12413 38 45 severe severe ADJ bam-12413 38 46 disability disability NOUN bam-12413 38 47 ) ) PUNCT bam-12413 38 48 to to ADP bam-12413 38 49 100 100 NUM bam-12413 38 50 ( ( PUNCT bam-12413 38 51 excellent excellent ADJ bam-12413 38 52 condition).31 condition).31 NOUN bam-12413 38 53 32 32 NUM bam-12413 38 54 non non X bam-12413 38 55 -co -co PROPN bam-12413 38 56 mmerc mmerc PROPN bam-12413 38 57 ial ial PROPN bam-12413 38 58 us us PROPN bam-12413 38 59 e e NOUN bam-12413 38 60 o o NOUN bam-12413 38 61 nly nly ADV bam-12413 38 62 intra intra ADJ bam-12413 38 63 - - ADJ bam-12413 38 64 articular articular ADJ bam-12413 38 65 injections injection NOUN bam-12413 38 66 with with ADP bam-12413 38 67 cmc cmc NOUN bam-12413 38 68 in in ADP bam-12413 38 69 patients patient NOUN bam-12413 38 70 affected affect VERB bam-12413 38 71 by by ADP bam-12413 38 72 knee knee NOUN bam-12413 38 73 oa oa PROPN bam-12413 38 74 in in ADP bam-12413 38 75 non non NOUN bam-12413 38 76 - - NOUN bam-12413 38 77 responders responder NOUN bam-12413 38 78 to to PART bam-12413 38 79 hyaluronic hyaluronic VERB bam-12413 38 80 acid acid NOUN bam-12413 38 81 eur eur PROPN bam-12413 38 82 j j PROPN bam-12413 38 83 transl transl PROPN bam-12413 38 84 myol myol NOUN bam-12413 38 85 34 34 NUM bam-12413 38 86 ( ( PUNCT bam-12413 38 87 3 3 NUM bam-12413 38 88 ) ) PUNCT bam-12413 38 89 12413 12413 NUM bam-12413 38 90 , , PUNCT bam-12413 38 91 2024 2024 NUM bam-12413 38 92 doi doi NOUN bam-12413 38 93 : : PUNCT bam-12413 38 94 10.4081 10.4081 NUM bam-12413 38 95 / / SYM bam-12413 38 96 ejtm.2024.12413 ejtm.2024.12413 PROPN bam-12413 38 97 statistical statistical ADJ bam-12413 38 98 analysis analysis NOUN bam-12413 38 99 all all DET bam-12413 38 100 data datum NOUN bam-12413 38 101 were be AUX bam-12413 38 102 initially initially ADV bam-12413 38 103 entered enter VERB bam-12413 38 104 into into ADP bam-12413 38 105 an an DET bam-12413 38 106 excel excel NOUN bam-12413 38 107 spreadsheet spreadsheet NOUN bam-12413 38 108 ( ( PUNCT bam-12413 38 109 microsoft microsoft PROPN bam-12413 38 110 , , PUNCT bam-12413 38 111 redmond redmond PROPN bam-12413 38 112 , , PUNCT bam-12413 38 113 washington washington PROPN bam-12413 38 114 , , PUNCT bam-12413 38 115 u.s.a u.s.a PROPN bam-12413 38 116 . . PUNCT bam-12413 38 117 ) ) PUNCT bam-12413 39 1 and and CCONJ bam-12413 39 2 analysis analysis NOUN bam-12413 39 3 was be AUX bam-12413 39 4 performed perform VERB bam-12413 39 5 using use VERB bam-12413 39 6 the the DET bam-12413 39 7 statistical statistical ADJ bam-12413 39 8 package package NOUN bam-12413 39 9 for for ADP bam-12413 39 10 the the DET bam-12413 39 11 social social ADJ bam-12413 39 12 sciences science NOUN bam-12413 39 13 windows window NOUN bam-12413 39 14 , , PUNCT bam-12413 39 15 version version NOUN bam-12413 39 16 15.0 15.0 NUM bam-12413 39 17 ( ( PUNCT bam-12413 39 18 spss spss PROPN bam-12413 39 19 , , PUNCT bam-12413 39 20 chicago chicago PROPN bam-12413 39 21 , , PUNCT bam-12413 39 22 illinois illinois PROPN bam-12413 39 23 , , PUNCT bam-12413 39 24 u.s.a u.s.a PROPN bam-12413 39 25 . . PUNCT bam-12413 39 26 ) ) PUNCT bam-12413 39 27 . . PUNCT bam-12413 40 1 descriptive descriptive ADJ bam-12413 40 2 statistics statistic NOUN bam-12413 40 3 shows show VERB bam-12413 40 4 mean mean VERB bam-12413 40 5 ± ± NUM bam-12413 40 6 standard standard ADJ bam-12413 40 7 deviation deviation NOUN bam-12413 40 8 ( ( PUNCT bam-12413 40 9 sd sd NOUN bam-12413 40 10 ) ) PUNCT bam-12413 40 11 since since SCONJ bam-12413 40 12 all all DET bam-12413 40 13 variables variable NOUN bam-12413 40 14 were be AUX bam-12413 40 15 normally normally ADV bam-12413 40 16 distributed distribute VERB bam-12413 40 17 parameters parameter NOUN bam-12413 40 18 after after ADP bam-12413 40 19 confirmation confirmation NOUN bam-12413 40 20 by by ADP bam-12413 40 21 the the DET bam-12413 40 22 kolgomorov kolgomorov ADJ bam-12413 40 23 - - PUNCT bam-12413 40 24 smirnov smirnov ADJ bam-12413 40 25 test.32 test.32 ADJ bam-12413 40 26 range range NOUN bam-12413 40 27 ( ( PUNCT bam-12413 40 28 min min NOUN bam-12413 40 29 ; ; PUNCT bam-12413 40 30 max max PROPN bam-12413 40 31 ) ) PUNCT bam-12413 40 32 is be AUX bam-12413 40 33 also also ADV bam-12413 40 34 reported report VERB bam-12413 40 35 as as ADP bam-12413 40 36 additional additional ADJ bam-12413 40 37 data datum NOUN bam-12413 40 38 . . PUNCT bam-12413 41 1 comparisons comparison NOUN bam-12413 41 2 between between ADP bam-12413 41 3 variables variable NOUN bam-12413 41 4 at at ADP bam-12413 41 5 different different ADJ bam-12413 41 6 times time NOUN bam-12413 41 7 were be AUX bam-12413 41 8 performed perform VERB bam-12413 41 9 with with ADP bam-12413 41 10 anova anova PROPN bam-12413 41 11 for for ADP bam-12413 41 12 repeated repeat VERB bam-12413 41 13 measures measure NOUN bam-12413 41 14 and and CCONJ bam-12413 41 15 post post ADJ bam-12413 41 16 - - ADJ bam-12413 41 17 hoc hoc ADJ bam-12413 41 18 bonferroni bonferroni NOUN bam-12413 41 19 test.33,34 test.33,34 NOUN bam-12413 41 20 a a DET bam-12413 41 21 value value NOUN bam-12413 41 22 of of ADP bam-12413 41 23 p<0.05 p<0.05 NOUN bam-12413 41 24 was be AUX bam-12413 41 25 considered consider VERB bam-12413 41 26 statistically statistically ADV bam-12413 41 27 significant significant ADJ bam-12413 41 28 . . PUNCT bam-12413 42 1 results result NOUN bam-12413 42 2 according accord VERB bam-12413 42 3 to to ADP bam-12413 42 4 the the DET bam-12413 42 5 inclusion inclusion NOUN bam-12413 42 6 and and CCONJ bam-12413 42 7 exclusion exclusion NOUN bam-12413 42 8 criteria criterion NOUN bam-12413 42 9 , , PUNCT bam-12413 42 10 10 10 NUM bam-12413 42 11 patients patient NOUN bam-12413 42 12 were be AUX bam-12413 42 13 enrolled enrol VERB bam-12413 42 14 in in ADP bam-12413 42 15 this this DET bam-12413 42 16 study study NOUN bam-12413 42 17 ; ; PUNCT bam-12413 42 18 male male NOUN bam-12413 42 19 ( ( PUNCT bam-12413 42 20 5 5 NUM bam-12413 42 21 , , PUNCT bam-12413 42 22 50 50 NUM bam-12413 42 23 % % NOUN bam-12413 42 24 ) ) PUNCT bam-12413 42 25 and and CCONJ bam-12413 42 26 female female ADJ bam-12413 42 27 ( ( PUNCT bam-12413 42 28 5 5 NUM bam-12413 42 29 , , PUNCT bam-12413 42 30 50 50 NUM bam-12413 42 31 % % NOUN bam-12413 42 32 ) ) PUNCT bam-12413 42 33 were be AUX bam-12413 42 34 equally equally ADV bam-12413 42 35 distributed distribute VERB bam-12413 42 36 . . PUNCT bam-12413 43 1 the the DET bam-12413 43 2 anthropometric anthropometric ADJ bam-12413 43 3 data datum NOUN bam-12413 43 4 of of ADP bam-12413 43 5 the the DET bam-12413 43 6 sample sample NOUN bam-12413 43 7 are be AUX bam-12413 43 8 reported report VERB bam-12413 43 9 in in ADP bam-12413 43 10 table table NOUN bam-12413 43 11 1 1 NUM bam-12413 43 12 . . PUNCT bam-12413 43 13 table table NOUN bam-12413 43 14 2 2 NUM bam-12413 43 15 shows show VERB bam-12413 43 16 the the DET bam-12413 43 17 descriptive descriptive ADJ bam-12413 43 18 analysis analysis NOUN bam-12413 43 19 of of ADP bam-12413 43 20 the the DET bam-12413 43 21 variables variable NOUN bam-12413 43 22 over over ADP bam-12413 43 23 time time NOUN bam-12413 43 24 . . PUNCT bam-12413 44 1 vas vas X bam-12413 44 2 ( ( PUNCT bam-12413 44 3 figure figure NOUN bam-12413 44 4 1 1 NUM bam-12413 44 5 ) ) PUNCT bam-12413 44 6 showed show VERB bam-12413 44 7 statistically statistically ADV bam-12413 44 8 significant significant ADJ bam-12413 44 9 changes change NOUN bam-12413 44 10 over over ADP bam-12413 44 11 time time NOUN bam-12413 44 12 at at ADP bam-12413 44 13 the the DET bam-12413 44 14 anova anova PROPN bam-12413 44 15 for for ADP bam-12413 44 16 repeated repeat VERB bam-12413 44 17 measures measure NOUN bam-12413 44 18 test test NOUN bam-12413 44 19 ( ( PUNCT bam-12413 44 20 p<0.01 p<0.01 PROPN bam-12413 44 21 ) ) PUNCT bam-12413 44 22 . . PUNCT bam-12413 45 1 at at ADP bam-12413 45 2 the the DET bam-12413 45 3 post post ADJ bam-12413 45 4 - - ADJ bam-12413 45 5 hoc hoc ADJ bam-12413 45 6 analysis analysis NOUN bam-12413 45 7 with with ADP bam-12413 45 8 the the DET bam-12413 45 9 bonferroni bonferroni NOUN bam-12413 45 10 test test NOUN bam-12413 45 11 , , PUNCT bam-12413 45 12 changes change NOUN bam-12413 45 13 were be AUX bam-12413 45 14 found find VERB bam-12413 45 15 between between ADP bam-12413 45 16 t0 t0 PROPN bam-12413 45 17 and and CCONJ bam-12413 45 18 t1 t1 PROPN bam-12413 45 19 ( ( PUNCT bam-12413 45 20 p<0.01 p<0.01 PROPN bam-12413 45 21 ) ) PUNCT bam-12413 45 22 representing represent VERB bam-12413 45 23 a a DET bam-12413 45 24 significant significant ADJ bam-12413 45 25 reduction reduction NOUN bam-12413 45 26 of of ADP bam-12413 45 27 pain pain NOUN bam-12413 45 28 . . PUNCT bam-12413 46 1 however however ADV bam-12413 46 2 , , PUNCT bam-12413 46 3 vas vas X bam-12413 46 4 scores score NOUN bam-12413 46 5 had have VERB bam-12413 46 6 an an DET bam-12413 46 7 ascending ascend VERB bam-12413 46 8 trend trend NOUN bam-12413 46 9 after after ADP bam-12413 46 10 t1 t1 PROPN bam-12413 46 11 , , PUNCT bam-12413 46 12 with with ADP bam-12413 46 13 a a DET bam-12413 46 14 significant significant ADJ bam-12413 46 15 worsening worsening NOUN bam-12413 46 16 when when SCONJ bam-12413 46 17 comparing compare VERB bam-12413 46 18 this this DET bam-12413 46 19 timepoint timepoint NOUN bam-12413 46 20 to to ADP bam-12413 46 21 t3 t3 PROPN bam-12413 46 22 ( ( PUNCT bam-12413 46 23 p=0.02 p=0.02 NOUN bam-12413 46 24 ) ) PUNCT bam-12413 46 25 and and CCONJ bam-12413 46 26 t6 t6 PROPN bam-12413 46 27 ( ( PUNCT bam-12413 46 28 p<0.01 p<0.01 PROPN bam-12413 46 29 ) ) PUNCT bam-12413 46 30 . . PUNCT bam-12413 47 1 all all DET bam-12413 47 2 koos koos PROPN bam-12413 47 3 domains domain NOUN bam-12413 47 4 ( ( PUNCT bam-12413 47 5 figure figure NOUN bam-12413 47 6 2 2 NUM bam-12413 47 7 - - SYM bam-12413 47 8 6 6 NUM bam-12413 47 9 ) ) PUNCT bam-12413 47 10 showed show VERB bam-12413 47 11 statistically statistically ADV bam-12413 47 12 significant significant ADJ bam-12413 47 13 changes change NOUN bam-12413 47 14 over over ADP bam-12413 47 15 time time NOUN bam-12413 47 16 at at ADP bam-12413 47 17 the the DET bam-12413 47 18 anova anova PROPN bam-12413 47 19 for for ADP bam-12413 47 20 repeated repeat VERB bam-12413 47 21 measures measure NOUN bam-12413 47 22 test test NOUN bam-12413 47 23 ( ( PUNCT bam-12413 47 24 pain pain NOUN bam-12413 47 25 p=0.02 p=0.02 NOUN bam-12413 47 26 ; ; PUNCT bam-12413 47 27 symptoms symptom NOUN bam-12413 47 28 p<0.01 p<0.01 PROPN bam-12413 47 29 ; ; PUNCT bam-12413 47 30 adl adl PROPN bam-12413 47 31 p<0.01 p<0.01 PROPN bam-12413 47 32 ; ; PUNCT bam-12413 47 33 qol qol PROPN bam-12413 47 34 p=0.01 p=0.01 PROPN bam-12413 47 35 ) ) PUNCT bam-12413 47 36 . . PUNCT bam-12413 48 1 the the DET bam-12413 48 2 only only ADJ bam-12413 48 3 exception exception NOUN bam-12413 48 4 was be AUX bam-12413 48 5 the the DET bam-12413 48 6 sport sport NOUN bam-12413 48 7 and and CCONJ bam-12413 48 8 recreational recreational ADJ bam-12413 48 9 activities activity NOUN bam-12413 48 10 related relate VERB bam-12413 48 11 domain domain NOUN bam-12413 48 12 ( ( PUNCT bam-12413 48 13 p=0.07 p=0.07 NOUN bam-12413 48 14 ) ) PUNCT bam-12413 48 15 . . PUNCT bam-12413 49 1 specifically specifically ADV bam-12413 49 2 , , PUNCT bam-12413 49 3 at at ADP bam-12413 49 4 the the DET bam-12413 49 5 post post ADJ bam-12413 49 6 - - ADJ bam-12413 49 7 hoc hoc ADJ bam-12413 49 8 analysis analysis NOUN bam-12413 49 9 with with ADP bam-12413 49 10 the the DET bam-12413 49 11 bonferroni bonferroni NOUN bam-12413 49 12 test test VERB bam-12413 49 13 all all DET bam-12413 49 14 the the DET bam-12413 49 15 domains domain NOUN bam-12413 49 16 analyzed analyze VERB bam-12413 49 17 showed show VERB bam-12413 49 18 a a DET bam-12413 49 19 significant significant ADJ bam-12413 49 20 improvement improvement NOUN bam-12413 49 21 at at ADP bam-12413 49 22 t1 t1 NOUN bam-12413 49 23 compared compare VERB bam-12413 49 24 to to ADP bam-12413 49 25 t0 t0 PROPN bam-12413 49 26 ( ( PUNCT bam-12413 49 27 pain pain PROPN bam-12413 49 28 p<0.01 p<0.01 PROPN bam-12413 49 29 ; ; PUNCT bam-12413 49 30 sym33 sym33 NOUN bam-12413 49 31 figure figure NOUN bam-12413 49 32 1 1 NUM bam-12413 49 33 . . PUNCT bam-12413 50 1 error error NOUN bam-12413 50 2 - - PUNCT bam-12413 50 3 bar bar NOUN bam-12413 50 4 of of ADP bam-12413 50 5 vas vas X bam-12413 50 6 variation variation NOUN bam-12413 50 7 during during ADP bam-12413 50 8 study study NOUN bam-12413 50 9 timeline timeline NOUN bam-12413 50 10 . . PUNCT bam-12413 51 1 figure figure NOUN bam-12413 51 2 2 2 NUM bam-12413 51 3 . . PUNCT bam-12413 51 4 error error NOUN bam-12413 51 5 - - PUNCT bam-12413 51 6 bar bar NOUN bam-12413 51 7 of of ADP bam-12413 51 8 the the DET bam-12413 51 9 symptoms symptom NOUN bam-12413 51 10 domain domain NOUN bam-12413 51 11 of of ADP bam-12413 51 12 koos koos PROPN bam-12413 51 13 variation variation NOUN bam-12413 51 14 during during ADP bam-12413 51 15 study study NOUN bam-12413 51 16 timeline timeline NOUN bam-12413 51 17 . . PUNCT bam-12413 52 1 table table NOUN bam-12413 52 2 1 1 NUM bam-12413 52 3 . . PUNCT bam-12413 53 1 anthropometric anthropometric ADJ bam-12413 53 2 data datum NOUN bam-12413 53 3 of of ADP bam-12413 53 4 the the DET bam-12413 53 5 sample sample NOUN bam-12413 53 6 . . PUNCT bam-12413 54 1 n n PRON bam-12413 54 2 mean mean VERB bam-12413 54 3 sd sd ADP bam-12413 54 4 min min PROPN bam-12413 54 5 . . PROPN bam-12413 54 6 max max PROPN bam-12413 54 7 . . PUNCT bam-12413 55 1 age age NOUN bam-12413 55 2 ( ( PUNCT bam-12413 55 3 yrs yrs PROPN bam-12413 55 4 ) ) PUNCT bam-12413 55 5 10 10 NUM bam-12413 55 6 74.5 74.5 NUM bam-12413 55 7 4.8 4.8 NUM bam-12413 55 8 68 68 NUM bam-12413 55 9 83 83 NUM bam-12413 55 10 weight weight NOUN bam-12413 55 11 ( ( PUNCT bam-12413 55 12 kgs kgs X bam-12413 55 13 ) ) PUNCT bam-12413 55 14 10 10 NUM bam-12413 55 15 80.6 80.6 NUM bam-12413 55 16 15.2 15.2 NUM bam-12413 55 17 56 56 NUM bam-12413 55 18 98 98 NUM bam-12413 55 19 height height NOUN bam-12413 55 20 ( ( PUNCT bam-12413 55 21 cms cms NOUN bam-12413 55 22 ) ) PUNCT bam-12413 55 23 10 10 NUM bam-12413 55 24 167.9 167.9 NUM bam-12413 55 25 8.7 8.7 NUM bam-12413 55 26 159 159 NUM bam-12413 55 27 178 178 NUM bam-12413 55 28 bmi bmi NOUN bam-12413 55 29 ( ( PUNCT bam-12413 55 30 kg kg NOUN bam-12413 55 31 / / SYM bam-12413 55 32 m2 m2 PROPN bam-12413 55 33 ) ) PUNCT bam-12413 55 34 10 10 NUM bam-12413 55 35 28.66 28.66 NUM bam-12413 55 36 5.60 5.60 NUM bam-12413 55 37 21.88 21.88 NUM bam-12413 55 38 38.28 38.28 NUM bam-12413 55 39 kl kl NOUN bam-12413 55 40 10 10 NUM bam-12413 55 41 3.6 3.6 NUM bam-12413 55 42 0.5 0.5 NUM bam-12413 55 43 3 3 NUM bam-12413 55 44 4 4 NUM bam-12413 55 45 non non ADJ bam-12413 55 46 -co -co PROPN bam-12413 55 47 mmerc mmerc PROPN bam-12413 55 48 ial ial PROPN bam-12413 55 49 us us PROPN bam-12413 56 1 e e NOUN bam-12413 56 2 o o NOUN bam-12413 56 3 nly nly ADV bam-12413 56 4 intra intra ADJ bam-12413 56 5 - - ADJ bam-12413 56 6 articular articular ADJ bam-12413 56 7 injections injection NOUN bam-12413 56 8 with with ADP bam-12413 56 9 cmc cmc NOUN bam-12413 56 10 in in ADP bam-12413 56 11 patients patient NOUN bam-12413 56 12 affected affect VERB bam-12413 56 13 by by ADP bam-12413 56 14 knee knee NOUN bam-12413 56 15 oa oa PROPN bam-12413 56 16 in in ADP bam-12413 56 17 non non NOUN bam-12413 56 18 - - NOUN bam-12413 56 19 responders responder NOUN bam-12413 56 20 to to PART bam-12413 56 21 hyaluronic hyaluronic VERB bam-12413 56 22 acid acid NOUN bam-12413 56 23 eur eur PROPN bam-12413 56 24 j j PROPN bam-12413 56 25 transl transl PROPN bam-12413 56 26 myol myol NOUN bam-12413 56 27 34 34 NUM bam-12413 56 28 ( ( PUNCT bam-12413 56 29 3 3 NUM bam-12413 56 30 ) ) PUNCT bam-12413 56 31 12413 12413 NUM bam-12413 56 32 , , PUNCT bam-12413 56 33 2024 2024 NUM bam-12413 56 34 doi doi NOUN bam-12413 56 35 : : PUNCT bam-12413 56 36 10.4081 10.4081 NUM bam-12413 56 37 / / SYM bam-12413 56 38 ejtm.2024.12413 ejtm.2024.12413 PROPN bam-12413 56 39 ptoms ptoms PROPN bam-12413 56 40 p=0.02 p=0.02 NOUN bam-12413 56 41 ; ; PUNCT bam-12413 56 42 adl adl PROPN bam-12413 56 43 p<0.01 p<0.01 PROPN bam-12413 56 44 ; ; PUNCT bam-12413 56 45 qol qol PROPN bam-12413 56 46 p=0.02 p=0.02 PROPN bam-12413 56 47 ) ) PUNCT bam-12413 56 48 . . PUNCT bam-12413 57 1 similar similar ADJ bam-12413 57 2 to to ADP bam-12413 57 3 vas vas PROPN bam-12413 57 4 , , PUNCT bam-12413 57 5 koos koos PROPN bam-12413 57 6 domain domain NOUN bam-12413 57 7 scores score NOUN bam-12413 57 8 showed show VERB bam-12413 57 9 a a DET bam-12413 57 10 deterioration deterioration NOUN bam-12413 57 11 trend trend NOUN bam-12413 57 12 after after ADP bam-12413 57 13 t1 t1 NOUN bam-12413 57 14 , , PUNCT bam-12413 57 15 too too ADV bam-12413 57 16 . . PUNCT bam-12413 58 1 however however ADV bam-12413 58 2 , , PUNCT bam-12413 58 3 the the DET bam-12413 58 4 worsening worsen VERB bam-12413 58 5 was be AUX bam-12413 58 6 n’t not PART bam-12413 58 7 statistically statistically ADV bam-12413 58 8 significant significant ADJ bam-12413 58 9 , , PUNCT bam-12413 58 10 except except SCONJ bam-12413 58 11 for for ADP bam-12413 58 12 the the DET bam-12413 58 13 symptoms symptom NOUN bam-12413 58 14 domain domain NOUN bam-12413 58 15 ( ( PUNCT bam-12413 58 16 figure figure NOUN bam-12413 58 17 2 2 NUM bam-12413 58 18 ) ) PUNCT bam-12413 58 19 at at ADP bam-12413 58 20 t6 t6 PROPN bam-12413 58 21 compared compare VERB bam-12413 58 22 to to ADP bam-12413 58 23 t1 t1 PROPN bam-12413 58 24 ( ( PUNCT bam-12413 58 25 p=0.03 p=0.03 ADJ bam-12413 58 26 ) ) PUNCT bam-12413 58 27 . . PUNCT bam-12413 59 1 discussion discussion NOUN bam-12413 59 2 ha ha INTJ bam-12413 59 3 is be AUX bam-12413 59 4 a a DET bam-12413 59 5 viable viable ADJ bam-12413 59 6 treatment treatment NOUN bam-12413 59 7 option option NOUN bam-12413 59 8 for for ADP bam-12413 59 9 advanced advanced ADJ bam-12413 59 10 knee knee NOUN bam-12413 59 11 oa.35 oa.35 NOUN bam-12413 59 12 in in ADP bam-12413 59 13 case case NOUN bam-12413 59 14 of of ADP bam-12413 59 15 treatment treatment NOUN bam-12413 59 16 failure failure NOUN bam-12413 59 17 , , PUNCT bam-12413 59 18 arthroscopic arthroscopic ADJ bam-12413 59 19 or or CCONJ bam-12413 59 20 surgical surgical ADJ bam-12413 59 21 approaches approach NOUN bam-12413 59 22 ( ( PUNCT bam-12413 59 23 i.e. i.e. X bam-12413 59 24 knee knee NOUN bam-12413 59 25 replacement replacement NOUN bam-12413 59 26 ) ) PUNCT bam-12413 59 27 are be AUX bam-12413 59 28 available available ADJ bam-12413 59 29 . . PUNCT bam-12413 60 1 total total ADJ bam-12413 60 2 knee knee NOUN bam-12413 60 3 arthroplasty arthroplasty NOUN bam-12413 60 4 is be AUX bam-12413 60 5 a a DET bam-12413 60 6 surgical surgical ADJ bam-12413 60 7 option option NOUN bam-12413 60 8 with with ADP bam-12413 60 9 a a DET bam-12413 60 10 success success NOUN bam-12413 60 11 rate rate NOUN bam-12413 60 12 , , PUNCT bam-12413 60 13 but but CCONJ bam-12413 60 14 34 34 NUM bam-12413 60 15 table table NOUN bam-12413 60 16 2 2 NUM bam-12413 60 17 . . PUNCT bam-12413 60 18 descriptive descriptive ADJ bam-12413 60 19 analysis analysis NOUN bam-12413 60 20 of of ADP bam-12413 60 21 the the DET bam-12413 60 22 variables variable NOUN bam-12413 60 23 over over ADP bam-12413 60 24 time time NOUN bam-12413 60 25 . . PUNCT bam-12413 61 1 t0 t0 PROPN bam-12413 61 2 t1 t1 PROPN bam-12413 61 3 t3 t3 PROPN bam-12413 61 4 t6 t6 PROPN bam-12413 61 5 n n PROPN bam-12413 61 6 10 10 NUM bam-12413 61 7 10 10 NUM bam-12413 61 8 10 10 NUM bam-12413 61 9 10 10 NUM bam-12413 61 10 vas vas NOUN bam-12413 61 11 mean mean NOUN bam-12413 61 12 72 72 NUM bam-12413 61 13 38.5 38.5 NUM bam-12413 61 14 58.5 58.5 NUM bam-12413 61 15 70.6 70.6 NUM bam-12413 61 16 sd sd ADP bam-12413 61 17 19.9 19.9 NUM bam-12413 61 18 21.6 21.6 NUM bam-12413 61 19 26.1 26.1 NUM bam-12413 61 20 21.9 21.9 NUM bam-12413 61 21 min min NOUN bam-12413 61 22 40 40 NUM bam-12413 61 23 20 20 NUM bam-12413 61 24 10 10 NUM bam-12413 61 25 30 30 NUM bam-12413 61 26 max max NOUN bam-12413 61 27 90 90 NUM bam-12413 61 28 70 70 NUM bam-12413 61 29 85 85 NUM bam-12413 61 30 100 100 NUM bam-12413 61 31 koos_pain koos_pain ADJ bam-12413 61 32 mean mean NOUN bam-12413 61 33 38.6 38.6 NUM bam-12413 61 34 60.2 60.2 NUM bam-12413 61 35 51.7 51.7 NUM bam-12413 61 36 44.1 44.1 NUM bam-12413 61 37 sd sd ADP bam-12413 61 38 17.9 17.9 NUM bam-12413 61 39 18.1 18.1 NUM bam-12413 61 40 21.4 21.4 NUM bam-12413 61 41 17.4 17.4 NUM bam-12413 61 42 min min NOUN bam-12413 61 43 11.1 11.1 NUM bam-12413 61 44 25 25 NUM bam-12413 61 45 11.1 11.1 NUM bam-12413 61 46 22 22 NUM bam-12413 62 1 max max PROPN bam-12413 62 2 63.9 63.9 NUM bam-12413 62 3 86.1 86.1 NUM bam-12413 62 4 88.8 88.8 NUM bam-12413 62 5 83.3 83.3 NUM bam-12413 62 6 koos_sym koos_sym PROPN bam-12413 62 7 mean mean VERB bam-12413 62 8 48.6 48.6 NUM bam-12413 62 9 63.5 63.5 NUM bam-12413 62 10 56.7 56.7 NUM bam-12413 62 11 47.8 47.8 NUM bam-12413 62 12 sd sd ADP bam-12413 62 13 14.1 14.1 NUM bam-12413 62 14 15.7 15.7 NUM bam-12413 62 15 16.4 16.4 NUM bam-12413 62 16 17.8 17.8 NUM bam-12413 62 17 min min NOUN bam-12413 62 18 28.6 28.6 NUM bam-12413 62 19 28.6 28.6 NUM bam-12413 62 20 25 25 NUM bam-12413 62 21 25 25 NUM bam-12413 62 22 max max PROPN bam-12413 62 23 71.4 71.4 NUM bam-12413 62 24 85.7 85.7 NUM bam-12413 62 25 85.7 85.7 NUM bam-12413 62 26 89.3 89.3 NUM bam-12413 62 27 koos_adl koos_adl NOUN bam-12413 62 28 mean mean VERB bam-12413 62 29 37.2 37.2 NUM bam-12413 62 30 63 63 NUM bam-12413 62 31 51.3 51.3 NUM bam-12413 62 32 47.9 47.9 NUM bam-12413 62 33 sd sd ADP bam-12413 62 34 17.6 17.6 NUM bam-12413 62 35 22.7 22.7 NUM bam-12413 62 36 15.6 15.6 NUM bam-12413 62 37 14.5 14.5 NUM bam-12413 62 38 min min NOUN bam-12413 62 39 7.4 7.4 NUM bam-12413 62 40 8.8 8.8 NUM bam-12413 62 41 25 25 NUM bam-12413 62 42 30.9 30.9 NUM bam-12413 62 43 max max NOUN bam-12413 62 44 58.8 58.8 NUM bam-12413 62 45 88.2 88.2 NUM bam-12413 62 46 79.4 79.4 NUM bam-12413 62 47 83.4 83.4 NUM bam-12413 63 1 koos koo NOUN bam-12413 64 1 sport sport NOUN bam-12413 64 2 mean mean VERB bam-12413 64 3 14.5 14.5 NUM bam-12413 64 4 35 35 NUM bam-12413 64 5 29.4 29.4 NUM bam-12413 64 6 15 15 NUM bam-12413 64 7 sd sd ADP bam-12413 64 8 23.1 23.1 NUM bam-12413 64 9 32.3 32.3 NUM bam-12413 64 10 17.1 17.1 NUM bam-12413 64 11 18.3 18.3 NUM bam-12413 64 12 min min NOUN bam-12413 64 13 0 0 NUM bam-12413 64 14 0 0 NUM bam-12413 64 15 5 5 NUM bam-12413 64 16 0 0 NUM bam-12413 64 17 max max NOUN bam-12413 64 18 75 75 NUM bam-12413 64 19 90 90 NUM bam-12413 64 20 55 55 NUM bam-12413 64 21 60 60 NUM bam-12413 64 22 koos_qol koos_qol NOUN bam-12413 64 23 mean mean VERB bam-12413 64 24 22.5 22.5 NUM bam-12413 64 25 36.8 36.8 NUM bam-12413 64 26 31.6 31.6 NUM bam-12413 64 27 32.8 32.8 NUM bam-12413 64 28 sd sd ADP bam-12413 64 29 11.8 11.8 NUM bam-12413 64 30 15.4 15.4 NUM bam-12413 64 31 22.1 22.1 NUM bam-12413 64 32 17.4 17.4 NUM bam-12413 64 33 min min NOUN bam-12413 64 34 6.3 6.3 NUM bam-12413 64 35 0 0 NUM bam-12413 64 36 0 0 NUM bam-12413 64 37 12.5 12.5 NUM bam-12413 64 38 max max NOUN bam-12413 64 39 43.7 43.7 NUM bam-12413 64 40 56.3 56.3 NUM bam-12413 64 41 81.2 81.2 NUM bam-12413 64 42 75 75 NUM bam-12413 64 43 vas vas X bam-12413 64 44 , , PUNCT bam-12413 64 45 visual visual ADJ bam-12413 64 46 analogue analogue NOUN bam-12413 64 47 scale scale NOUN bam-12413 64 48 ; ; PUNCT bam-12413 64 49 koos koos PROPN bam-12413 64 50 pain pain NOUN bam-12413 64 51 , , PUNCT bam-12413 64 52 pain pain NOUN bam-12413 64 53 domain domain NOUN bam-12413 64 54 of of ADP bam-12413 64 55 the the DET bam-12413 64 56 koos koos PROPN bam-12413 64 57 scale scale NOUN bam-12413 64 58 ; ; PUNCT bam-12413 64 59 koos koos PROPN bam-12413 64 60 sym sym PROPN bam-12413 64 61 , , PUNCT bam-12413 64 62 symptoms symptom NOUN bam-12413 64 63 domain domain NOUN bam-12413 64 64 of of ADP bam-12413 64 65 the the DET bam-12413 64 66 koos koos PROPN bam-12413 64 67 scale scale NOUN bam-12413 64 68 ; ; PUNCT bam-12413 64 69 koos koos PROPN bam-12413 64 70 adl adl PROPN bam-12413 64 71 , , PUNCT bam-12413 64 72 activities activity NOUN bam-12413 64 73 of of ADP bam-12413 64 74 daily daily ADJ bam-12413 64 75 living living NOUN bam-12413 64 76 domain domain NOUN bam-12413 64 77 of of ADP bam-12413 64 78 the the DET bam-12413 64 79 koos koos PROPN bam-12413 64 80 scale scale NOUN bam-12413 64 81 ; ; PUNCT bam-12413 64 82 koos koos PROPN bam-12413 64 83 sport sport PROPN bam-12413 64 84 , , PUNCT bam-12413 64 85 sport sport NOUN bam-12413 64 86 and and CCONJ bam-12413 64 87 recreational recreational ADJ bam-12413 64 88 activities activity NOUN bam-12413 64 89 domain domain NOUN bam-12413 64 90 of of ADP bam-12413 64 91 the the DET bam-12413 64 92 koos koos PROPN bam-12413 64 93 scale scale NOUN bam-12413 64 94 ; ; PUNCT bam-12413 64 95 koos koos PROPN bam-12413 64 96 qol qol PROPN bam-12413 64 97 , , PUNCT bam-12413 64 98 quality quality NOUN bam-12413 64 99 of of ADP bam-12413 64 100 life life NOUN bam-12413 64 101 domain domain NOUN bam-12413 64 102 of of ADP bam-12413 64 103 the the DET bam-12413 64 104 koos koos PROPN bam-12413 64 105 scale scale NOUN bam-12413 64 106 . . PUNCT bam-12413 65 1 non non ADJ bam-12413 65 2 -co -co PROPN bam-12413 65 3 mmerc mmerc PROPN bam-12413 65 4 ial ial PROPN bam-12413 65 5 us us PROPN bam-12413 65 6 e e NOUN bam-12413 65 7 o o NOUN bam-12413 65 8 nly nly ADV bam-12413 65 9 intra intra ADJ bam-12413 65 10 - - ADJ bam-12413 65 11 articular articular ADJ bam-12413 65 12 injections injection NOUN bam-12413 65 13 with with ADP bam-12413 65 14 cmc cmc NOUN bam-12413 65 15 in in ADP bam-12413 65 16 patients patient NOUN bam-12413 65 17 affected affect VERB bam-12413 65 18 by by ADP bam-12413 65 19 knee knee NOUN bam-12413 65 20 oa oa PROPN bam-12413 65 21 in in ADP bam-12413 65 22 non non NOUN bam-12413 65 23 - - NOUN bam-12413 65 24 responders responder NOUN bam-12413 65 25 to to PART bam-12413 65 26 hyaluronic hyaluronic VERB bam-12413 65 27 acid acid NOUN bam-12413 65 28 eur eur PROPN bam-12413 65 29 j j PROPN bam-12413 65 30 transl transl PROPN bam-12413 65 31 myol myol NOUN bam-12413 65 32 34 34 NUM bam-12413 65 33 ( ( PUNCT bam-12413 65 34 3 3 NUM bam-12413 65 35 ) ) PUNCT bam-12413 65 36 12413 12413 NUM bam-12413 65 37 , , PUNCT bam-12413 65 38 2024 2024 NUM bam-12413 65 39 doi doi NOUN bam-12413 65 40 : : PUNCT bam-12413 65 41 10.4081 10.4081 NUM bam-12413 65 42 / / SYM bam-12413 65 43 ejtm.2024.12413 ejtm.2024.12413 PROPN bam-12413 65 44 with with ADP bam-12413 65 45 bio bio ADJ bam-12413 65 46 - - ADJ bam-12413 65 47 mechanical mechanical ADJ bam-12413 65 48 implications implication NOUN bam-12413 65 49 that that PRON bam-12413 65 50 often often ADV bam-12413 65 51 cause cause VERB bam-12413 65 52 progression progression NOUN bam-12413 65 53 of of ADP bam-12413 65 54 oa oa PRON bam-12413 65 55 in in ADP bam-12413 65 56 the the DET bam-12413 65 57 contralateral contralateral ADJ bam-12413 65 58 knee knee NOUN bam-12413 65 59 ; ; PUNCT bam-12413 65 60 arthroplasty arthroplasty NOUN bam-12413 65 61 is be AUX bam-12413 65 62 often often ADV bam-12413 65 63 required require VERB bam-12413 65 64 at at ADP bam-12413 65 65 the the DET bam-12413 65 66 contralateral contralateral ADJ bam-12413 65 67 knee knee NOUN bam-12413 65 68 as as ADV bam-12413 65 69 well well ADV bam-12413 65 70 , , PUNCT bam-12413 65 71 with with ADP bam-12413 65 72 all all DET bam-12413 65 73 the the DET bam-12413 65 74 consequent consequent ADJ bam-12413 65 75 surgical surgical ADJ bam-12413 65 76 risks risk NOUN bam-12413 65 77 and and CCONJ bam-12413 65 78 additional additional ADJ bam-12413 65 79 biomechanical biomechanical ADJ bam-12413 65 80 implications.36 implications.36 NOUN bam-12413 65 81 nowadays nowadays ADV bam-12413 65 82 , , PUNCT bam-12413 65 83 non non ADJ bam-12413 65 84 - - ADJ bam-12413 65 85 surgical surgical ADJ bam-12413 65 86 alternatives alternative NOUN bam-12413 65 87 for for ADP bam-12413 65 88 non non NOUN bam-12413 65 89 - - NOUN bam-12413 65 90 responders responder NOUN bam-12413 65 91 with with ADP bam-12413 65 92 advanced advanced ADJ bam-12413 65 93 oa oa NOUN bam-12413 65 94 are be AUX bam-12413 65 95 however however ADV bam-12413 65 96 very very ADV bam-12413 65 97 limited.37 limited.37 NOUN bam-12413 65 98 research research NOUN bam-12413 65 99 is be AUX bam-12413 65 100 ongoing ongoing ADJ bam-12413 65 101 on on ADP bam-12413 65 102 this this DET bam-12413 65 103 topic topic NOUN bam-12413 65 104 but but CCONJ bam-12413 65 105 there there PRON bam-12413 65 106 is be VERB bam-12413 65 107 still still ADV bam-12413 65 108 little little ADJ bam-12413 65 109 data datum NOUN bam-12413 65 110 available available ADJ bam-12413 65 111 . . PUNCT bam-12413 66 1 a a DET bam-12413 66 2 recent recent ADJ bam-12413 66 3 paper paper NOUN bam-12413 66 4 involving involve VERB bam-12413 66 5 9 9 NUM bam-12413 66 6 patients patient NOUN bam-12413 66 7 ( ( PUNCT bam-12413 66 8 4 4 NUM bam-12413 66 9 female female ADJ bam-12413 66 10 , , PUNCT bam-12413 66 11 5 5 NUM bam-12413 66 12 male male NOUN bam-12413 66 13 ) ) PUNCT bam-12413 66 14 , , PUNCT bam-12413 66 15 kl kl PROPN bam-12413 66 16 2 2 NUM bam-12413 66 17 - - SYM bam-12413 66 18 3 3 NUM bam-12413 66 19 , , PUNCT bam-12413 66 20 showed show VERB bam-12413 66 21 a a DET bam-12413 66 22 reduction reduction NOUN bam-12413 66 23 of of ADP bam-12413 66 24 pain pain NOUN bam-12413 66 25 and and CCONJ bam-12413 66 26 an an DET bam-12413 66 27 increase increase NOUN bam-12413 66 28 of of ADP bam-12413 66 29 functional functional ADJ bam-12413 66 30 outcomes outcome NOUN bam-12413 66 31 after after ADP bam-12413 66 32 intra intra ADJ bam-12413 66 33 - - ADJ bam-12413 66 34 articular articular ADJ bam-12413 66 35 injections injection NOUN bam-12413 66 36 in in ADP bam-12413 66 37 the the DET bam-12413 66 38 knee knee NOUN bam-12413 66 39 with with ADP bam-12413 66 40 clodronate clodronate NOUN bam-12413 66 41 plus plus CCONJ bam-12413 66 42 lidocaine.38 lidocaine.38 PROPN bam-12413 66 43 finding find VERB bam-12413 66 44 a a DET bam-12413 66 45 new new ADJ bam-12413 66 46 treatment treatment NOUN bam-12413 66 47 option option NOUN bam-12413 66 48 would would AUX bam-12413 66 49 thus thus ADV bam-12413 66 50 be be AUX bam-12413 66 51 of of ADP bam-12413 66 52 paramount paramount ADJ bam-12413 66 53 importance importance NOUN bam-12413 66 54 for for ADP bam-12413 66 55 two two NUM bam-12413 66 56 reasons reason NOUN bam-12413 66 57 . . PUNCT bam-12413 67 1 the the DET bam-12413 67 2 first first ADJ bam-12413 67 3 is be AUX bam-12413 67 4 to to PART bam-12413 67 5 give give VERB bam-12413 67 6 the the DET bam-12413 67 7 patient patient ADJ bam-12413 67 8 time time NOUN bam-12413 67 9 to to PART bam-12413 67 10 think think VERB bam-12413 67 11 without without ADP bam-12413 67 12 rushing rush VERB bam-12413 67 13 about about ADP bam-12413 67 14 the the DET bam-12413 67 15 management management NOUN bam-12413 67 16 of of ADP bam-12413 67 17 their their PRON bam-12413 67 18 body body NOUN bam-12413 67 19 , , PUNCT bam-12413 67 20 having have VERB bam-12413 67 21 the the DET bam-12413 67 22 opportunity opportunity NOUN bam-12413 67 23 to to PART bam-12413 67 24 choose choose VERB bam-12413 67 25 the the DET bam-12413 67 26 course course NOUN bam-12413 67 27 of of ADP bam-12413 67 28 care care NOUN bam-12413 67 29 and and CCONJ bam-12413 67 30 eventual eventual ADJ bam-12413 67 31 surgical surgical ADJ bam-12413 67 32 setting setting NOUN bam-12413 67 33 they they PRON bam-12413 67 34 prefer prefer VERB bam-12413 67 35 , , PUNCT bam-12413 67 36 considering consider VERB bam-12413 67 37 the the DET bam-12413 67 38 possible possible ADJ bam-12413 67 39 need need NOUN bam-12413 67 40 for for ADP bam-12413 67 41 knee knee NOUN bam-12413 67 42 replacement replacement NOUN bam-12413 67 43 surgery surgery NOUN bam-12413 67 44 . . PUNCT bam-12413 68 1 the the DET bam-12413 68 2 second second ADJ bam-12413 68 3 , , PUNCT bam-12413 68 4 and and CCONJ bam-12413 68 5 probably probably ADV bam-12413 68 6 the the DET bam-12413 68 7 most most ADV bam-12413 68 8 important important ADJ bam-12413 68 9 , , PUNCT bam-12413 68 10 is be AUX bam-12413 68 11 to to PART bam-12413 68 12 improve improve VERB bam-12413 68 13 patients patient NOUN bam-12413 68 14 ' ' PART bam-12413 68 15 qol qol NOUN bam-12413 68 16 even even ADV bam-12413 68 17 if if SCONJ bam-12413 68 18 only only ADV bam-12413 68 19 for for ADP bam-12413 68 20 a a DET bam-12413 68 21 short short ADJ bam-12413 68 22 period period NOUN bam-12413 68 23 ( ( PUNCT bam-12413 68 24 e.g. e.g. ADV bam-12413 68 25 , , PUNCT bam-12413 68 26 up up ADP bam-12413 68 27 to to PART bam-12413 68 28 4 4 NUM bam-12413 68 29 - - SYM bam-12413 68 30 6 6 NUM bam-12413 68 31 months month NOUN bam-12413 68 32 ) ) PUNCT bam-12413 68 33 by by ADP bam-12413 68 34 increasing increase VERB bam-12413 68 35 their their PRON bam-12413 68 36 independence independence NOUN bam-12413 68 37 in in ADP bam-12413 68 38 adl adl PROPN bam-12413 68 39 and and CCONJ bam-12413 68 40 empowering empower VERB bam-12413 68 41 them they PRON bam-12413 68 42 to to PART bam-12413 68 43 carry carry VERB bam-12413 68 44 on on ADP bam-12413 68 45 their their PRON bam-12413 68 46 personal personal ADJ bam-12413 68 47 passions passion NOUN bam-12413 68 48 , , PUNCT bam-12413 68 49 hobbies hobby NOUN bam-12413 68 50 , , PUNCT bam-12413 68 51 and and CCONJ bam-12413 68 52 even even ADV bam-12413 68 53 work work NOUN bam-12413 68 54 activities activity NOUN bam-12413 68 55 . . PUNCT bam-12413 69 1 the the DET bam-12413 69 2 bio bio ADJ bam-12413 69 3 - - ADJ bam-12413 69 4 psycho psycho ADJ bam-12413 69 5 - - PUNCT bam-12413 69 6 social social ADJ bam-12413 69 7 approach approach NOUN bam-12413 69 8 of of ADP bam-12413 69 9 the the DET bam-12413 69 10 icf icf PROPN bam-12413 69 11 and and CCONJ bam-12413 69 12 the the DET bam-12413 69 13 holistic holistic ADJ bam-12413 69 14 view view NOUN bam-12413 69 15 of of ADP bam-12413 69 16 the the DET bam-12413 69 17 person person NOUN bam-12413 69 18 dictate dictate VERB bam-12413 69 19 that that SCONJ bam-12413 69 20 these these DET bam-12413 69 21 aspects aspect NOUN bam-12413 69 22 must must AUX bam-12413 69 23 be be AUX bam-12413 69 24 kept keep VERB bam-12413 69 25 in in ADP bam-12413 69 26 mind mind NOUN bam-12413 69 27 in in ADP bam-12413 69 28 the the DET bam-12413 69 29 rehabilitation rehabilitation NOUN bam-12413 69 30 setting.39 setting.39 NOUN bam-12413 69 31 to to ADP bam-12413 69 32 the the DET bam-12413 69 33 best good ADJ bam-12413 69 34 of of ADP bam-12413 69 35 our our PRON bam-12413 69 36 knowledge knowledge NOUN bam-12413 69 37 , , PUNCT bam-12413 69 38 at at ADP bam-12413 69 39 the the DET bam-12413 69 40 current current ADJ bam-12413 69 41 time time NOUN bam-12413 69 42 , , PUNCT bam-12413 69 43 only only ADV bam-12413 69 44 two two NUM bam-12413 69 45 studies study NOUN bam-12413 69 46 have have AUX bam-12413 69 47 been be AUX bam-12413 69 48 published publish VERB bam-12413 69 49 regarding regard VERB bam-12413 69 50 the the DET bam-12413 69 51 use use NOUN bam-12413 69 52 of of ADP bam-12413 69 53 cm cm NOUN bam-12413 69 54 - - PUNCT bam-12413 69 55 c c NOUN bam-12413 69 56 for for ADP bam-12413 69 57 the the DET bam-12413 69 58 treatment treatment NOUN bam-12413 69 59 of of ADP bam-12413 69 60 knee knee NOUN bam-12413 69 61 oa oa NOUN bam-12413 69 62 via via ADP bam-12413 69 63 injection injection NOUN bam-12413 69 64 therapy therapy NOUN bam-12413 69 65 in in ADP bam-12413 69 66 human human ADJ bam-12413 69 67 beings being NOUN bam-12413 69 68 , , PUNCT bam-12413 69 69 both both CCONJ bam-12413 69 70 by by ADP bam-12413 69 71 emans eman NOUN bam-12413 69 72 et et PROPN bam-12413 69 73 al al PROPN bam-12413 69 74 . . PROPN bam-12413 70 1 one one NUM bam-12413 70 2 of of ADP bam-12413 70 3 them40 them40 NOUN bam-12413 70 4 is be AUX bam-12413 70 5 the the DET bam-12413 70 6 post post ADJ bam-12413 70 7 - - ADJ bam-12413 70 8 hoc hoc ADJ bam-12413 70 9 analysis analysis NOUN bam-12413 70 10 of of ADP bam-12413 70 11 the the DET bam-12413 70 12 other.26 other.26 ADJ bam-12413 70 13 the the DET bam-12413 70 14 important important ADJ bam-12413 70 15 difference difference NOUN bam-12413 70 16 between between ADP bam-12413 70 17 35 35 NUM bam-12413 70 18 figure figure NOUN bam-12413 70 19 3 3 NUM bam-12413 70 20 . . PUNCT bam-12413 70 21 error error NOUN bam-12413 70 22 - - PUNCT bam-12413 70 23 bar bar NOUN bam-12413 70 24 of of ADP bam-12413 70 25 the the DET bam-12413 70 26 pain pain NOUN bam-12413 70 27 domain domain NOUN bam-12413 70 28 of of ADP bam-12413 70 29 koos koos PROPN bam-12413 70 30 variation variation NOUN bam-12413 70 31 during during ADP bam-12413 70 32 the the DET bam-12413 70 33 study study NOUN bam-12413 70 34 timeline timeline NOUN bam-12413 70 35 . . PUNCT bam-12413 71 1 figure figure VERB bam-12413 71 2 4 4 NUM bam-12413 71 3 . . PUNCT bam-12413 72 1 error error NOUN bam-12413 72 2 - - PUNCT bam-12413 72 3 bar bar NOUN bam-12413 72 4 of of ADP bam-12413 72 5 the the DET bam-12413 72 6 sports sport NOUN bam-12413 72 7 and and CCONJ bam-12413 72 8 recreational recreational ADJ bam-12413 72 9 activities activity NOUN bam-12413 72 10 domain domain NOUN bam-12413 72 11 of of ADP bam-12413 72 12 koos koos PROPN bam-12413 72 13 . . PUNCT bam-12413 73 1 figure figure NOUN bam-12413 73 2 5 5 NUM bam-12413 73 3 . . PUNCT bam-12413 74 1 error error NOUN bam-12413 74 2 - - PUNCT bam-12413 74 3 bar bar NOUN bam-12413 74 4 of of ADP bam-12413 74 5 the the DET bam-12413 74 6 adl adl PROPN bam-12413 74 7 domain domain NOUN bam-12413 74 8 of of ADP bam-12413 74 9 koos koos PROPN bam-12413 74 10 variation variation NOUN bam-12413 74 11 during during ADP bam-12413 74 12 the the DET bam-12413 74 13 study study NOUN bam-12413 74 14 timeline timeline NOUN bam-12413 74 15 . . PUNCT bam-12413 75 1 figure figure VERB bam-12413 75 2 6 6 NUM bam-12413 75 3 . . PUNCT bam-12413 76 1 error error NOUN bam-12413 76 2 - - PUNCT bam-12413 76 3 bar bar NOUN bam-12413 76 4 of of ADP bam-12413 76 5 the the DET bam-12413 76 6 qol qol PROPN bam-12413 76 7 domain domain NOUN bam-12413 76 8 of of ADP bam-12413 76 9 koos koos PROPN bam-12413 76 10 variation variation NOUN bam-12413 76 11 during during ADP bam-12413 76 12 the the DET bam-12413 76 13 study study NOUN bam-12413 76 14 timeline timeline NOUN bam-12413 76 15 . . PUNCT bam-12413 77 1 non non ADJ bam-12413 78 1 -co -co PROPN bam-12413 78 2 mmerc mmerc PROPN bam-12413 78 3 ial ial PROPN bam-12413 78 4 us us PROPN bam-12413 78 5 e e NOUN bam-12413 78 6 o o NOUN bam-12413 78 7 nly nly ADV bam-12413 78 8 intra intra ADJ bam-12413 78 9 - - ADJ bam-12413 78 10 articular articular ADJ bam-12413 78 11 injections injection NOUN bam-12413 78 12 with with ADP bam-12413 78 13 cmc cmc NOUN bam-12413 78 14 in in ADP bam-12413 78 15 patients patient NOUN bam-12413 78 16 affected affect VERB bam-12413 78 17 by by ADP bam-12413 78 18 knee knee NOUN bam-12413 78 19 oa oa PROPN bam-12413 78 20 in in ADP bam-12413 78 21 non non NOUN bam-12413 78 22 - - NOUN bam-12413 78 23 responders responder NOUN bam-12413 78 24 to to PART bam-12413 78 25 hyaluronic hyaluronic VERB bam-12413 78 26 acid acid NOUN bam-12413 78 27 eur eur PROPN bam-12413 78 28 j j PROPN bam-12413 78 29 transl transl PROPN bam-12413 78 30 myol myol NOUN bam-12413 78 31 34 34 NUM bam-12413 78 32 ( ( PUNCT bam-12413 78 33 3 3 NUM bam-12413 78 34 ) ) PUNCT bam-12413 78 35 12413 12413 NUM bam-12413 78 36 , , PUNCT bam-12413 78 37 2024 2024 NUM bam-12413 78 38 doi doi NOUN bam-12413 78 39 : : PUNCT bam-12413 78 40 10.4081 10.4081 NUM bam-12413 78 41 / / SYM bam-12413 78 42 ejtm.2024.12413 ejtm.2024.12413 PROPN bam-12413 78 43 our our PRON bam-12413 78 44 study study NOUN bam-12413 78 45 and and CCONJ bam-12413 78 46 these these DET bam-12413 78 47 two two NUM bam-12413 78 48 is be AUX bam-12413 78 49 that that SCONJ bam-12413 78 50 in in ADP bam-12413 78 51 the the DET bam-12413 78 52 other other ADJ bam-12413 78 53 two two NUM bam-12413 78 54 , , PUNCT bam-12413 78 55 non non ADJ bam-12413 78 56 - - ADJ bam-12413 78 57 responding respond VERB bam-12413 78 58 patients patient NOUN bam-12413 78 59 were be AUX bam-12413 78 60 not not PART bam-12413 78 61 recruited recruit VERB bam-12413 78 62 . . PUNCT bam-12413 79 1 moreover moreover ADV bam-12413 79 2 , , PUNCT bam-12413 79 3 despite despite SCONJ bam-12413 79 4 the the DET bam-12413 79 5 small small ADJ bam-12413 79 6 number number NOUN bam-12413 79 7 of of ADP bam-12413 79 8 participants participant NOUN bam-12413 79 9 , , PUNCT bam-12413 79 10 this this PRON bam-12413 79 11 is be AUX bam-12413 79 12 the the DET bam-12413 79 13 first first ADJ bam-12413 79 14 study study NOUN bam-12413 79 15 conducted conduct VERB bam-12413 79 16 in in ADP bam-12413 79 17 italy italy PROPN bam-12413 79 18 aimed aim VERB bam-12413 79 19 to to PART bam-12413 79 20 evaluate evaluate VERB bam-12413 79 21 the the DET bam-12413 79 22 efficacy efficacy NOUN bam-12413 79 23 of of ADP bam-12413 79 24 a a DET bam-12413 79 25 single single ADJ bam-12413 79 26 intra intra ADJ bam-12413 79 27 - - ADJ bam-12413 79 28 articular articular ADJ bam-12413 79 29 cm cm NOUN bam-12413 79 30 - - PUNCT bam-12413 79 31 c c NOUN bam-12413 79 32 injection injection NOUN bam-12413 79 33 for for ADP bam-12413 79 34 the the DET bam-12413 79 35 treatment treatment NOUN bam-12413 79 36 of of ADP bam-12413 79 37 patients patient NOUN bam-12413 79 38 with with ADP bam-12413 79 39 advanced advanced ADJ bam-12413 79 40 and and CCONJ bam-12413 79 41 symptomatic symptomatic ADJ bam-12413 79 42 knee knee NOUN bam-12413 79 43 oa oa NOUN bam-12413 79 44 unresponsive unresponsive ADJ bam-12413 79 45 to to ADP bam-12413 79 46 ha ha INTJ bam-12413 79 47 treatment treatment NOUN bam-12413 79 48 . . PUNCT bam-12413 80 1 in in ADP bam-12413 80 2 our our PRON bam-12413 80 3 innovative innovative ADJ bam-12413 80 4 study study NOUN bam-12413 80 5 , , PUNCT bam-12413 80 6 we we PRON bam-12413 80 7 aimed aim VERB bam-12413 80 8 to to PART bam-12413 80 9 evaluate evaluate VERB bam-12413 80 10 the the DET bam-12413 80 11 efficacy efficacy NOUN bam-12413 80 12 of of ADP bam-12413 80 13 a a DET bam-12413 80 14 single single ADJ bam-12413 80 15 intra intra ADJ bam-12413 80 16 - - ADJ bam-12413 80 17 articular articular ADJ bam-12413 80 18 cm cm NOUN bam-12413 80 19 - - PUNCT bam-12413 80 20 c c NOUN bam-12413 80 21 injection injection NOUN bam-12413 80 22 for for ADP bam-12413 80 23 the the DET bam-12413 80 24 treatment treatment NOUN bam-12413 80 25 of of ADP bam-12413 80 26 patients patient NOUN bam-12413 80 27 with with ADP bam-12413 80 28 advanced advanced ADJ bam-12413 80 29 and and CCONJ bam-12413 80 30 symptomatic symptomatic ADJ bam-12413 80 31 knee knee NOUN bam-12413 80 32 oa oa NOUN bam-12413 80 33 unresponsive unresponsive ADJ bam-12413 80 34 to to ADP bam-12413 80 35 ha ha INTJ bam-12413 80 36 treatment treatment NOUN bam-12413 80 37 . . PUNCT bam-12413 81 1 after after ADP bam-12413 81 2 data data NOUN bam-12413 81 3 analysis analysis NOUN bam-12413 81 4 , , PUNCT bam-12413 81 5 cm cm NOUN bam-12413 81 6 - - PUNCT bam-12413 81 7 c c NOUN bam-12413 81 8 seems seem VERB bam-12413 81 9 to to PART bam-12413 81 10 show show VERB bam-12413 81 11 a a DET bam-12413 81 12 clear clear ADJ bam-12413 81 13 efficacy efficacy NOUN bam-12413 81 14 one one NUM bam-12413 81 15 month month NOUN bam-12413 81 16 after after ADP bam-12413 81 17 treatment treatment NOUN bam-12413 81 18 ( ( PUNCT bam-12413 81 19 t1 t1 NOUN bam-12413 81 20 ) ) PUNCT bam-12413 81 21 . . PUNCT bam-12413 82 1 patients patient NOUN bam-12413 82 2 reported report VERB bam-12413 82 3 a a DET bam-12413 82 4 significant significant ADJ bam-12413 82 5 reduction reduction NOUN bam-12413 82 6 in in ADP bam-12413 82 7 pain pain NOUN bam-12413 82 8 and and CCONJ bam-12413 82 9 a a DET bam-12413 82 10 significant significant ADJ bam-12413 82 11 increase increase NOUN bam-12413 82 12 in in ADP bam-12413 82 13 knee knee NOUN bam-12413 82 14 function function NOUN bam-12413 82 15 ( ( PUNCT bam-12413 82 16 mobility mobility NOUN bam-12413 82 17 and and CCONJ bam-12413 82 18 swelling swelling NOUN bam-12413 82 19 ) ) PUNCT bam-12413 82 20 , , PUNCT bam-12413 82 21 independence independence NOUN bam-12413 82 22 in in ADP bam-12413 82 23 adl adl PROPN bam-12413 82 24 , , PUNCT bam-12413 82 25 and and CCONJ bam-12413 82 26 general general ADJ bam-12413 82 27 qol qol NOUN bam-12413 82 28 at at ADP bam-12413 82 29 t1 t1 NOUN bam-12413 82 30 as as SCONJ bam-12413 82 31 evidenced evidence VERB bam-12413 82 32 by by ADP bam-12413 82 33 the the DET bam-12413 82 34 changes change NOUN bam-12413 82 35 in in ADP bam-12413 82 36 the the DET bam-12413 82 37 pain pain NOUN bam-12413 82 38 , , PUNCT bam-12413 82 39 symptoms symptom NOUN bam-12413 82 40 , , PUNCT bam-12413 82 41 adl adl PROPN bam-12413 82 42 , , PUNCT bam-12413 82 43 and and CCONJ bam-12413 82 44 qol qol PROPN bam-12413 82 45 koos koos PROPN bam-12413 82 46 domains domain NOUN bam-12413 82 47 plus plus CCONJ bam-12413 82 48 vas vas X bam-12413 82 49 . . PUNCT bam-12413 83 1 in in ADP bam-12413 83 2 the the DET bam-12413 83 3 following following ADJ bam-12413 83 4 months month NOUN bam-12413 83 5 , , PUNCT bam-12413 83 6 though though ADV bam-12413 83 7 , , PUNCT bam-12413 83 8 these these DET bam-12413 83 9 indicators indicator NOUN bam-12413 83 10 showed show VERB bam-12413 83 11 a a DET bam-12413 83 12 trend trend NOUN bam-12413 83 13 of of ADP bam-12413 83 14 gradual gradual ADJ bam-12413 83 15 worsening worsening NOUN bam-12413 83 16 : : PUNCT bam-12413 83 17 at at ADP bam-12413 83 18 the the DET bam-12413 83 19 following follow VERB bam-12413 83 20 study study NOUN bam-12413 83 21 time time NOUN bam-12413 83 22 - - PUNCT bam-12413 83 23 points point NOUN bam-12413 83 24 patients patient NOUN bam-12413 83 25 reported report VERB bam-12413 83 26 ascent ascent NOUN bam-12413 83 27 of of ADP bam-12413 83 28 pain pain NOUN bam-12413 83 29 and and CCONJ bam-12413 83 30 descent descent NOUN bam-12413 83 31 of of ADP bam-12413 83 32 koos koos PROPN bam-12413 83 33 functional functional ADJ bam-12413 83 34 outcomes outcome NOUN bam-12413 83 35 . . PUNCT bam-12413 84 1 these these DET bam-12413 84 2 results result NOUN bam-12413 84 3 are be AUX bam-12413 84 4 not not PART bam-12413 84 5 in in ADP bam-12413 84 6 line line NOUN bam-12413 84 7 with with ADP bam-12413 84 8 the the DET bam-12413 84 9 other other ADJ bam-12413 84 10 two two NUM bam-12413 84 11 available available ADJ bam-12413 84 12 studies study NOUN bam-12413 84 13 on on ADP bam-12413 84 14 this this DET bam-12413 84 15 topic topic NOUN bam-12413 84 16 which which PRON bam-12413 84 17 showed show VERB bam-12413 84 18 a a DET bam-12413 84 19 clear clear ADJ bam-12413 84 20 efficacy efficacy NOUN bam-12413 84 21 , , PUNCT bam-12413 84 22 although although SCONJ bam-12413 84 23 the the DET bam-12413 84 24 population population NOUN bam-12413 84 25 difference difference NOUN bam-12413 84 26 between between ADP bam-12413 84 27 the the DET bam-12413 84 28 studies study NOUN bam-12413 84 29 should should AUX bam-12413 84 30 be be AUX bam-12413 84 31 considered consider VERB bam-12413 84 32 . . PUNCT bam-12413 85 1 emans eman NOUN bam-12413 85 2 et et AUX bam-12413 85 3 al al PROPN bam-12413 85 4 . . PROPN bam-12413 85 5 found find VERB bam-12413 85 6 clear clear ADJ bam-12413 85 7 improvement improvement NOUN bam-12413 85 8 in in ADP bam-12413 85 9 pain pain NOUN bam-12413 85 10 and and CCONJ bam-12413 85 11 functional functional ADJ bam-12413 85 12 outcomes outcome NOUN bam-12413 85 13 up up ADP bam-12413 85 14 to to PART bam-12413 85 15 6 6 NUM bam-12413 85 16 months month NOUN bam-12413 85 17 post post ADJ bam-12413 85 18 - - ADJ bam-12413 85 19 injection.26,40 injection.26,40 ADJ bam-12413 85 20 in in ADP bam-12413 85 21 our our PRON bam-12413 85 22 case case NOUN bam-12413 85 23 , , PUNCT bam-12413 85 24 it it PRON bam-12413 85 25 is be AUX bam-12413 85 26 important important ADJ bam-12413 85 27 to to PART bam-12413 85 28 note note VERB bam-12413 85 29 that that SCONJ bam-12413 85 30 at at ADP bam-12413 85 31 t2 t2 NOUN bam-12413 85 32 several several ADJ bam-12413 85 33 scores score NOUN bam-12413 85 34 retained retain VERB bam-12413 85 35 better well ADJ bam-12413 85 36 raw raw ADJ bam-12413 85 37 values value NOUN bam-12413 85 38 than than ADP bam-12413 85 39 t0 t0 NOUN bam-12413 85 40 , , PUNCT bam-12413 85 41 albeit albeit SCONJ bam-12413 85 42 without without ADP bam-12413 85 43 reaching reach VERB bam-12413 85 44 statistical statistical ADJ bam-12413 85 45 significance significance NOUN bam-12413 85 46 . . PUNCT bam-12413 86 1 even even ADV bam-12413 86 2 at at ADP bam-12413 86 3 t3 t3 PROPN bam-12413 86 4 , , PUNCT bam-12413 86 5 almost almost ADV bam-12413 86 6 all all DET bam-12413 86 7 variables variable NOUN bam-12413 86 8 returned return VERB bam-12413 86 9 to to ADP bam-12413 86 10 raw raw ADJ bam-12413 86 11 values value NOUN bam-12413 86 12 that that PRON bam-12413 86 13 still still ADV bam-12413 86 14 showed show VERB bam-12413 86 15 a a DET bam-12413 86 16 small small ADJ bam-12413 86 17 improvement improvement NOUN bam-12413 86 18 though though SCONJ bam-12413 86 19 being be AUX bam-12413 86 20 roughly roughly ADV bam-12413 86 21 similar similar ADJ bam-12413 86 22 to to ADP bam-12413 86 23 those those PRON bam-12413 86 24 observed observe VERB bam-12413 86 25 before before ADP bam-12413 86 26 treatment treatment NOUN bam-12413 86 27 . . PUNCT bam-12413 87 1 patients patient NOUN bam-12413 87 2 thus thus ADV bam-12413 87 3 on on ADP bam-12413 87 4 average average ADJ bam-12413 87 5 reported report VERB bam-12413 87 6 a a DET bam-12413 87 7 positive positive ADJ bam-12413 87 8 trend trend NOUN bam-12413 87 9 in in ADP bam-12413 87 10 the the DET bam-12413 87 11 first first ADJ bam-12413 87 12 few few ADJ bam-12413 87 13 months month NOUN bam-12413 87 14 after after ADP bam-12413 87 15 treatment treatment NOUN bam-12413 87 16 , , PUNCT bam-12413 87 17 and and CCONJ bam-12413 87 18 probably probably ADV bam-12413 87 19 the the DET bam-12413 87 20 small small ADJ bam-12413 87 21 sample sample NOUN bam-12413 87 22 size size NOUN bam-12413 87 23 prevented prevent VERB bam-12413 87 24 greater great ADJ bam-12413 87 25 statistical statistical ADJ bam-12413 87 26 evidence evidence NOUN bam-12413 87 27 . . PUNCT bam-12413 88 1 limitations limitation NOUN bam-12413 88 2 this this DET bam-12413 88 3 study study NOUN bam-12413 88 4 has have VERB bam-12413 88 5 several several ADJ bam-12413 88 6 limitations limitation NOUN bam-12413 88 7 such such ADJ bam-12413 88 8 as as ADP bam-12413 88 9 a a DET bam-12413 88 10 small small ADJ bam-12413 88 11 sample sample NOUN bam-12413 88 12 size size NOUN bam-12413 88 13 , , PUNCT bam-12413 88 14 a a DET bam-12413 88 15 short short ADJ bam-12413 88 16 follow follow NOUN bam-12413 88 17 - - PUNCT bam-12413 88 18 up up NOUN bam-12413 88 19 period period NOUN bam-12413 88 20 , , PUNCT bam-12413 88 21 the the DET bam-12413 88 22 absence absence NOUN bam-12413 88 23 of of ADP bam-12413 88 24 a a DET bam-12413 88 25 control control NOUN bam-12413 88 26 group group NOUN bam-12413 88 27 and and CCONJ bam-12413 88 28 its its PRON bam-12413 88 29 retrospective retrospective ADJ bam-12413 88 30 design design NOUN bam-12413 88 31 . . PUNCT bam-12413 89 1 these these DET bam-12413 89 2 limitations limitation NOUN bam-12413 89 3 did do AUX bam-12413 89 4 not not PART bam-12413 89 5 allow allow VERB bam-12413 89 6 a a DET bam-12413 89 7 more more ADJ bam-12413 89 8 in in ADP bam-12413 89 9 - - PUNCT bam-12413 89 10 depth depth NOUN bam-12413 89 11 statistical statistical ADJ bam-12413 89 12 analysis analysis NOUN bam-12413 89 13 . . PUNCT bam-12413 90 1 conclusions conclusion NOUN bam-12413 90 2 this this PRON bam-12413 90 3 is be AUX bam-12413 90 4 the the DET bam-12413 90 5 first first ADJ bam-12413 90 6 study study NOUN bam-12413 90 7 conducted conduct VERB bam-12413 90 8 in in ADP bam-12413 90 9 italy italy PROPN bam-12413 90 10 to to PART bam-12413 90 11 evaluate evaluate VERB bam-12413 90 12 the the DET bam-12413 90 13 effects effect NOUN bam-12413 90 14 of of ADP bam-12413 90 15 a a DET bam-12413 90 16 single single ADJ bam-12413 90 17 intra intra ADJ bam-12413 90 18 - - ADJ bam-12413 90 19 articular articular ADJ bam-12413 90 20 cm cm NOUN bam-12413 90 21 - - PUNCT bam-12413 90 22 c c NOUN bam-12413 90 23 injection injection NOUN bam-12413 90 24 for for ADP bam-12413 90 25 the the DET bam-12413 90 26 treatment treatment NOUN bam-12413 90 27 of of ADP bam-12413 90 28 patients patient NOUN bam-12413 90 29 with with ADP bam-12413 90 30 knee knee NOUN bam-12413 90 31 oa oa PROPN bam-12413 90 32 unresponsive unresponsive ADJ bam-12413 90 33 to to ADP bam-12413 90 34 ha ha INTJ bam-12413 90 35 . . PUNCT bam-12413 91 1 this this DET bam-12413 91 2 retrospective retrospective ADJ bam-12413 91 3 study study NOUN bam-12413 91 4 suggests suggest VERB bam-12413 91 5 a a DET bam-12413 91 6 short short ADV bam-12413 91 7 - - PUNCT bam-12413 91 8 lasting last VERB bam-12413 91 9 overall overall ADJ bam-12413 91 10 efficacy efficacy NOUN bam-12413 91 11 of of ADP bam-12413 91 12 cm cm NOUN bam-12413 91 13 - - PUNCT bam-12413 91 14 c c NOUN bam-12413 91 15 for for ADP bam-12413 91 16 the the DET bam-12413 91 17 treatment treatment NOUN bam-12413 91 18 of of ADP bam-12413 91 19 patients patient NOUN bam-12413 91 20 with with ADP bam-12413 91 21 advanced advanced ADJ bam-12413 91 22 knee knee NOUN bam-12413 91 23 oa oa X bam-12413 91 24 ( ( PUNCT bam-12413 91 25 kl≥3 kl≥3 PROPN bam-12413 91 26 ) ) PUNCT bam-12413 91 27 non non NOUN bam-12413 91 28 - - NOUN bam-12413 91 29 responders responder NOUN bam-12413 91 30 to to ADP bam-12413 91 31 intra intra ADJ bam-12413 91 32 - - ADJ bam-12413 91 33 articular articular ADJ bam-12413 91 34 ha ha INTJ bam-12413 91 35 injection injection NOUN bam-12413 91 36 . . PUNCT bam-12413 92 1 reduction reduction NOUN bam-12413 92 2 in in ADP bam-12413 92 3 pain pain NOUN bam-12413 92 4 and and CCONJ bam-12413 92 5 increase increase VERB bam-12413 92 6 in in ADP bam-12413 92 7 functional functional ADJ bam-12413 92 8 outcomes outcome NOUN bam-12413 92 9 were be AUX bam-12413 92 10 observed observe VERB bam-12413 92 11 clearly clearly ADV bam-12413 92 12 at at ADP bam-12413 92 13 one one NUM bam-12413 92 14 month month NOUN bam-12413 92 15 after after ADP bam-12413 92 16 cm cm NOUN bam-12413 92 17 - - PUNCT bam-12413 92 18 c c NOUN bam-12413 92 19 injections injection NOUN bam-12413 92 20 but but CCONJ bam-12413 92 21 lasted last VERB bam-12413 92 22 only only ADV bam-12413 92 23 as as ADP bam-12413 92 24 a a DET bam-12413 92 25 small small ADJ bam-12413 92 26 improvement improvement NOUN bam-12413 92 27 in in ADP bam-12413 92 28 the the DET bam-12413 92 29 next next ADJ bam-12413 92 30 study study NOUN bam-12413 92 31 time time NOUN bam-12413 92 32 - - PUNCT bam-12413 92 33 points point NOUN bam-12413 92 34 up up ADP bam-12413 92 35 to to PART bam-12413 92 36 6 6 NUM bam-12413 92 37 months month NOUN bam-12413 92 38 . . PUNCT bam-12413 93 1 cm cm NOUN bam-12413 93 2 - - PUNCT bam-12413 93 3 c c NOUN bam-12413 93 4 could could AUX bam-12413 93 5 then then ADV bam-12413 93 6 appear appear VERB bam-12413 93 7 as as ADP bam-12413 93 8 a a DET bam-12413 93 9 treatment treatment NOUN bam-12413 93 10 option option NOUN bam-12413 93 11 for for SCONJ bam-12413 93 12 this this DET bam-12413 93 13 population population NOUN bam-12413 93 14 to to PART bam-12413 93 15 extend extend VERB bam-12413 93 16 the the DET bam-12413 93 17 time time NOUN bam-12413 93 18 to to ADP bam-12413 93 19 surgery surgery NOUN bam-12413 93 20 and and CCONJ bam-12413 93 21 make make VERB bam-12413 93 22 the the DET bam-12413 93 23 decision decision NOUN bam-12413 93 24 more more ADV bam-12413 93 25 informed informed ADJ bam-12413 93 26 . . PUNCT bam-12413 94 1 the the DET bam-12413 94 2 albeit albeit SCONJ bam-12413 94 3 small small ADJ bam-12413 94 4 improvement improvement NOUN bam-12413 94 5 in in ADP bam-12413 94 6 qol qol NOUN bam-12413 94 7 in in ADP bam-12413 94 8 people people NOUN bam-12413 94 9 who who PRON bam-12413 94 10 have have VERB bam-12413 94 11 few few ADJ bam-12413 94 12 or or CCONJ bam-12413 94 13 no no PRON bam-12413 94 14 alternatives alternative NOUN bam-12413 94 15 for for ADP bam-12413 94 16 treatment treatment NOUN bam-12413 94 17 of of ADP bam-12413 94 18 a a DET bam-12413 94 19 disabling disable VERB bam-12413 94 20 condition condition NOUN bam-12413 94 21 such such ADJ bam-12413 94 22 as as ADP bam-12413 94 23 advanced advanced ADJ bam-12413 94 24 knee knee NOUN bam-12413 94 25 oa oa PRON bam-12413 94 26 should should AUX bam-12413 94 27 not not PART bam-12413 94 28 be be AUX bam-12413 94 29 neglected neglect VERB bam-12413 94 30 . . PUNCT bam-12413 95 1 list list NOUN bam-12413 95 2 of of ADP bam-12413 95 3 acronyms acronyms PROPN bam-12413 95 4 adl adl PROPN bam-12413 95 5 : : PUNCT bam-12413 95 6 activities activity NOUN bam-12413 95 7 of of ADP bam-12413 95 8 daily daily ADJ bam-12413 95 9 living living NOUN bam-12413 95 10 . . PUNCT bam-12413 96 1 cm cm NOUN bam-12413 96 2 - - PUNCT bam-12413 96 3 c c NOUN bam-12413 96 4 : : PUNCT bam-12413 96 5 carboxymethyl carboxymethyl NOUN bam-12413 96 6 - - PUNCT bam-12413 96 7 chitosan chitosan NOUN bam-12413 96 8 . . PUNCT bam-12413 97 1 ha ha INTJ bam-12413 97 2 : : PUNCT bam-12413 97 3 hyaluronic hyaluronic ADJ bam-12413 97 4 acid acid NOUN bam-12413 97 5 . . PUNCT bam-12413 98 1 kl kl NOUN bam-12413 98 2 : : PUNCT bam-12413 98 3 kellgren kellgren PROPN bam-12413 98 4 - - PUNCT bam-12413 98 5 lawrence lawrence PROPN bam-12413 98 6 . . PUNCT bam-12413 99 1 koos koos PROPN bam-12413 99 2 : : PUNCT bam-12413 100 1 knee knee NOUN bam-12413 100 2 injury injury NOUN bam-12413 100 3 and and CCONJ bam-12413 100 4 osteoarthritis osteoarthritis NOUN bam-12413 100 5 outcome outcome NOUN bam-12413 100 6 score score NOUN bam-12413 100 7 . . PUNCT bam-12413 101 1 nsaids nsaid NOUN bam-12413 101 2 : : PUNCT bam-12413 101 3 non non ADJ bam-12413 101 4 - - ADJ bam-12413 101 5 steroidal steroidal ADJ bam-12413 101 6 anti anti ADJ bam-12413 101 7 - - ADJ bam-12413 101 8 inflammatories inflammatorie NOUN bam-12413 101 9 drugs drug NOUN bam-12413 101 10 . . PUNCT bam-12413 102 1 oa oa X bam-12413 102 2 : : PUNCT bam-12413 102 3 osteoarthritis osteoarthritis NOUN bam-12413 102 4 . . PUNCT bam-12413 103 1 qol qol NOUN bam-12413 103 2 : : PUNCT bam-12413 103 3 quality quality NOUN bam-12413 103 4 of of ADP bam-12413 103 5 life life NOUN bam-12413 103 6 . . PUNCT bam-12413 104 1 sd sd NOUN bam-12413 104 2 : : PUNCT bam-12413 104 3 standard standard ADJ bam-12413 104 4 deviation deviation NOUN bam-12413 104 5 . . PUNCT bam-12413 105 1 vas vas ADJ bam-12413 105 2 : : PUNCT bam-12413 105 3 visual visual ADJ bam-12413 105 4 analogue analogue NOUN bam-12413 105 5 scale scale NOUN bam-12413 105 6 . . PUNCT bam-12413 106 1 contributions contribution NOUN bam-12413 106 2 nm nm PROPN bam-12413 106 3 , , PUNCT bam-12413 106 4 investigation investigation NOUN bam-12413 106 5 , , PUNCT bam-12413 106 6 writing write VERB bam-12413 106 7 original original ADJ bam-12413 106 8 draft draft NOUN bam-12413 106 9 , , PUNCT bam-12413 106 10 review review NOUN bam-12413 106 11 and and CCONJ bam-12413 106 12 editing editing NOUN bam-12413 106 13 ; ; PUNCT bam-12413 106 14 cl cl NOUN bam-12413 106 15 , , PUNCT bam-12413 106 16 methodology methodology NOUN bam-12413 106 17 , , PUNCT bam-12413 106 18 writing writing NOUN bam-12413 106 19 – – PUNCT bam-12413 106 20 review review NOUN bam-12413 106 21 and and CCONJ bam-12413 106 22 editing editing NOUN bam-12413 106 23 ; ; PUNCT bam-12413 106 24 np np INTJ bam-12413 106 25 , , PUNCT bam-12413 106 26 gv gv ADP bam-12413 106 27 : : PUNCT bam-12413 106 28 investigation investigation NOUN bam-12413 106 29 , , PUNCT bam-12413 106 30 writing write VERB bam-12413 106 31 – – PUNCT bam-12413 106 32 original original ADJ bam-12413 106 33 draft draft NOUN bam-12413 106 34 ; ; PUNCT bam-12413 106 35 rs r NOUN bam-12413 106 36 , , PUNCT bam-12413 106 37 formal formal ADJ bam-12413 106 38 analysis analysis NOUN bam-12413 106 39 ; ; PUNCT bam-12413 106 40 cf cf NOUN bam-12413 106 41 , , PUNCT bam-12413 106 42 conceptualization conceptualization NOUN bam-12413 106 43 , , PUNCT bam-12413 106 44 supervision supervision NOUN bam-12413 106 45 , , PUNCT bam-12413 106 46 writing write VERB bam-12413 106 47 review review NOUN bam-12413 106 48 and and CCONJ bam-12413 106 49 editing editing NOUN bam-12413 106 50 . . PUNCT bam-12413 107 1 conflict conflict NOUN bam-12413 107 2 of of ADP bam-12413 107 3 interest interest NOUN bam-12413 107 4 all all DET bam-12413 107 5 authors author NOUN bam-12413 107 6 have have AUX bam-12413 107 7 read read VERB bam-12413 107 8 and and CCONJ bam-12413 107 9 approved approve VERB bam-12413 107 10 this this DET bam-12413 107 11 manuscript manuscript NOUN bam-12413 107 12 . . PUNCT bam-12413 108 1 the the DET bam-12413 108 2 authors author NOUN bam-12413 108 3 declare declare VERB bam-12413 108 4 no no DET bam-12413 108 5 conflicts conflict NOUN bam-12413 108 6 of of ADP bam-12413 108 7 interest interest NOUN bam-12413 108 8 . . PUNCT bam-12413 109 1 funding fund VERB bam-12413 109 2 no no DET bam-12413 109 3 funding funding NOUN bam-12413 109 4 was be AUX bam-12413 109 5 needed need VERB bam-12413 109 6 or or CCONJ bam-12413 109 7 requested request VERB bam-12413 109 8 . . PUNCT bam-12413 110 1 ethics ethic NOUN bam-12413 110 2 approval approval VERB bam-12413 110 3 the the DET bam-12413 110 4 territorial territorial ADJ bam-12413 110 5 ethics ethic NOUN bam-12413 110 6 committee committee PROPN bam-12413 110 7 “ " PUNCT bam-12413 110 8 lazio lazio PROPN bam-12413 110 9 area area NOUN bam-12413 110 10 2 2 NUM bam-12413 110 11 ” " PUNCT bam-12413 110 12 approved approve VERB bam-12413 110 13 this this DET bam-12413 110 14 study study NOUN bam-12413 110 15 ( ( PUNCT bam-12413 110 16 173.24 173.24 NUM bam-12413 110 17 ) ) PUNCT bam-12413 110 18 . . PUNCT bam-12413 111 1 the the DET bam-12413 111 2 study study NOUN bam-12413 111 3 conforms conform VERB bam-12413 111 4 with with ADP bam-12413 111 5 the the DET bam-12413 111 6 helsinki helsinki PROPN bam-12413 111 7 declaration declaration NOUN bam-12413 111 8 of of ADP bam-12413 111 9 1964 1964 NUM bam-12413 111 10 , , PUNCT bam-12413 111 11 as as SCONJ bam-12413 111 12 revised revise VERB bam-12413 111 13 in in ADP bam-12413 111 14 2013 2013 NUM bam-12413 111 15 , , PUNCT bam-12413 111 16 concerning concern VERB bam-12413 111 17 human human ADJ bam-12413 111 18 and and CCONJ bam-12413 111 19 animal animal NOUN bam-12413 111 20 rights right NOUN bam-12413 111 21 . . PUNCT bam-12413 112 1 informed inform VERB bam-12413 112 2 consent consent NOUN bam-12413 112 3 all all DET bam-12413 112 4 patients patient NOUN bam-12413 112 5 participating participate VERB bam-12413 112 6 in in ADP bam-12413 112 7 this this DET bam-12413 112 8 study study NOUN bam-12413 112 9 signed sign VERB bam-12413 112 10 a a DET bam-12413 112 11 written write VERB bam-12413 112 12 informed inform VERB bam-12413 112 13 consent consent NOUN bam-12413 112 14 form form NOUN bam-12413 112 15 for for ADP bam-12413 112 16 participating participate VERB bam-12413 112 17 in in ADP bam-12413 112 18 this this DET bam-12413 112 19 study study NOUN bam-12413 112 20 . . PUNCT bam-12413 113 1 patient patient ADJ bam-12413 113 2 consent consent NOUN bam-12413 113 3 for for ADP bam-12413 113 4 publication publication NOUN bam-12413 113 5 written write VERB bam-12413 113 6 informed inform VERB bam-12413 113 7 consent consent NOUN bam-12413 113 8 was be AUX bam-12413 113 9 obtained obtain VERB bam-12413 113 10 from from ADP bam-12413 113 11 a a DET bam-12413 113 12 legally legally ADV bam-12413 113 13 authorized authorize VERB bam-12413 113 14 representative(s representative(s NOUN bam-12413 113 15 ) ) PUNCT bam-12413 113 16 for for ADP bam-12413 113 17 anonymized anonymize VERB bam-12413 113 18 patient patient ADJ bam-12413 113 19 information information NOUN bam-12413 113 20 to to PART bam-12413 113 21 be be AUX bam-12413 113 22 published publish VERB bam-12413 113 23 in in ADP bam-12413 113 24 this this DET bam-12413 113 25 article article NOUN bam-12413 113 26 . . PUNCT bam-12413 114 1 availability availability NOUN bam-12413 114 2 of of ADP bam-12413 114 3 data datum NOUN bam-12413 114 4 and and CCONJ bam-12413 114 5 materials material NOUN bam-12413 114 6 all all DET bam-12413 114 7 data datum NOUN bam-12413 114 8 generated generate VERB bam-12413 114 9 or or CCONJ bam-12413 114 10 analyzed analyze VERB bam-12413 114 11 during during ADP bam-12413 114 12 this this DET bam-12413 114 13 study study NOUN bam-12413 114 14 are be AUX bam-12413 114 15 included include VERB bam-12413 114 16 in in ADP bam-12413 114 17 this this DET bam-12413 114 18 published publish VERB bam-12413 114 19 article article NOUN bam-12413 114 20 . . PUNCT bam-12413 115 1 corresponding correspond VERB bam-12413 115 2 author author PROPN bam-12413 115 3 calogero calogero PROPN bam-12413 115 4 foti foti PROPN bam-12413 115 5 , , PUNCT bam-12413 115 6 physical physical ADJ bam-12413 115 7 and and CCONJ bam-12413 115 8 rehabilitation rehabilitation NOUN bam-12413 115 9 medicine medicine NOUN bam-12413 115 10 , , PUNCT bam-12413 115 11 clinical clinical ADJ bam-12413 115 12 sciences science NOUN bam-12413 115 13 and and CCONJ bam-12413 115 14 translational translational ADJ bam-12413 115 15 medicine medicine NOUN bam-12413 115 16 department department PROPN bam-12413 115 17 , , PUNCT bam-12413 115 18 university university PROPN bam-12413 115 19 of of ADP bam-12413 115 20 rome rome PROPN bam-12413 115 21 tor tor PROPN bam-12413 115 22 vergata vergata NOUN bam-12413 115 23 , , PUNCT bam-12413 115 24 via via ADP bam-12413 115 25 montpellier montpellier NOUN bam-12413 115 26 1 1 NUM bam-12413 115 27 , , PUNCT bam-12413 115 28 00133 00133 NUM bam-12413 115 29 , , PUNCT bam-12413 115 30 rome rome PROPN bam-12413 115 31 , , PUNCT bam-12413 115 32 italy italy PROPN bam-12413 115 33 . . PUNCT bam-12413 116 1 tel tel PROPN bam-12413 116 2 . . PUNCT bam-12413 116 3 : : PUNCT bam-12413 117 1 +39.0620.900594 +39.0620.900594 X bam-12413 117 2 . . NOUN bam-12413 117 3 36 36 NUM bam-12413 117 4 non non ADJ bam-12413 117 5 -co -co PROPN bam-12413 117 6 mmerc mmerc PROPN bam-12413 117 7 ial ial PROPN bam-12413 117 8 us us PROPN bam-12413 117 9 e e NOUN bam-12413 117 10 o o NOUN bam-12413 117 11 nly nly ADV bam-12413 117 12 intra intra ADJ bam-12413 117 13 - - ADJ bam-12413 117 14 articular articular ADJ bam-12413 117 15 injections injection NOUN bam-12413 117 16 with with ADP bam-12413 117 17 cmc cmc NOUN bam-12413 117 18 in in ADP bam-12413 117 19 patients patient NOUN bam-12413 117 20 affected affect VERB bam-12413 117 21 by by ADP bam-12413 117 22 knee knee NOUN bam-12413 117 23 oa oa PROPN bam-12413 117 24 in in ADP bam-12413 117 25 non non NOUN bam-12413 117 26 - - NOUN bam-12413 117 27 responders responder NOUN bam-12413 117 28 to to PART bam-12413 117 29 hyaluronic hyaluronic VERB bam-12413 117 30 acid acid NOUN bam-12413 117 31 eur eur PROPN bam-12413 117 32 j j PROPN bam-12413 117 33 transl transl PROPN bam-12413 117 34 myol myol NOUN bam-12413 117 35 34 34 NUM bam-12413 117 36 ( ( PUNCT bam-12413 117 37 3 3 NUM bam-12413 117 38 ) ) PUNCT bam-12413 117 39 12413 12413 NUM bam-12413 117 40 , , PUNCT bam-12413 117 41 2024 2024 NUM bam-12413 117 42 doi doi NOUN bam-12413 117 43 : : PUNCT bam-12413 117 44 10.4081 10.4081 NUM bam-12413 117 45 / / SYM bam-12413 117 46 ejtm.2024.12413 ejtm.2024.12413 PROPN bam-12413 117 47 orcid orcid NOUN bam-12413 117 48 i i NOUN bam-12413 117 49 d d NOUN bam-12413 117 50 : : PUNCT bam-12413 117 51 0000 0000 NUM bam-12413 117 52 - - PUNCT bam-12413 117 53 0003 0003 NUM bam-12413 117 54 - - PUNCT bam-12413 117 55 2246 2246 NUM bam-12413 117 56 - - PUNCT bam-12413 117 57 348x 348x NUM bam-12413 117 58 e e NOUN bam-12413 117 59 - - NOUN bam-12413 117 60 mail mail NOUN bam-12413 117 61 : : PUNCT bam-12413 117 62 foti@med.uniroma2.it foti@med.uniroma2.it PROPN bam-12413 117 63 nicola nicola PROPN bam-12413 117 64 manocchio manocchio PROPN bam-12413 117 65 orcid orcid PROPN bam-12413 118 1 i i PRON bam-12413 118 2 d d NOUN bam-12413 118 3 : : PUNCT bam-12413 118 4 0009 0009 NUM bam-12413 118 5 - - PUNCT bam-12413 118 6 0009 0009 NUM bam-12413 118 7 - - PUNCT bam-12413 118 8 9900 9900 NUM bam-12413 118 9 - - SYM bam-12413 118 10 4725 4725 NUM bam-12413 118 11 e e NOUN bam-12413 118 12 - - NOUN bam-12413 118 13 mail mail NOUN bam-12413 118 14 : : PUNCT bam-12413 118 15 nicola.manocchio@uniroma2.it nicola.manocchio@uniroma2.it PROPN bam-12413 118 16 concetta concetta PROPN bam-12413 118 17 ljoka ljoka NOUN bam-12413 118 18 orcid orcid NOUN bam-12413 118 19 i i PRON bam-12413 118 20 d d NOUN bam-12413 118 21 : : PUNCT bam-12413 118 22 0000 0000 NUM bam-12413 118 23 - - PUNCT bam-12413 118 24 0001 0001 NUM bam-12413 118 25 - - PUNCT bam-12413 118 26 6260 6260 NUM bam-12413 118 27 - - SYM bam-12413 118 28 8474 8474 NUM bam-12413 118 29 e e NOUN bam-12413 118 30 - - NOUN bam-12413 118 31 mail mail NOUN bam-12413 118 32 : : PUNCT bam-12413 118 33 concetta.ljoka@ptvonline.it concetta.ljoka@ptvonline.it PROPN bam-12413 118 34 nicolò nicolò PROPN bam-12413 118 35 piacentini piacentini VERB bam-12413 118 36 orcid orcid NOUN bam-12413 119 1 i i NOUN bam-12413 119 2 d d NOUN bam-12413 119 3 : : PUNCT bam-12413 119 4 0009 0009 NUM bam-12413 119 5 - - PUNCT bam-12413 119 6 0004 0004 NUM bam-12413 119 7 - - PUNCT bam-12413 119 8 3773 3773 NUM bam-12413 119 9 - - PUNCT bam-12413 119 10 3934 3934 NUM bam-12413 119 11 e e NOUN bam-12413 119 12 - - NOUN bam-12413 119 13 mail mail NOUN bam-12413 119 14 : : PUNCT bam-12413 120 1 nicolo.piacentini@students.uniroma2.eu nicolo.piacentini@students.uniroma2.eu NOUN bam-12413 120 2 roberto roberto PROPN bam-12413 120 3 sorge sorge PROPN bam-12413 120 4 orcid orcid PROPN bam-12413 121 1 i i PRON bam-12413 121 2 d d NOUN bam-12413 121 3 : : PUNCT bam-12413 121 4 0000 0000 NUM bam-12413 121 5 - - PUNCT bam-12413 121 6 0002 0002 NUM bam-12413 121 7 - - PUNCT bam-12413 121 8 4513 4513 NUM bam-12413 121 9 - - PUNCT bam-12413 121 10 151x 151x NUM bam-12413 121 11 e e NOUN bam-12413 121 12 - - NOUN bam-12413 121 13 mail mail NOUN bam-12413 121 14 : : PUNCT bam-12413 121 15 sorge@uniroma2.it sorge@uniroma2.it PROPN bam-12413 121 16 giulia giulia PROPN bam-12413 121 17 vita vita NOUN bam-12413 121 18 orcid orcid NOUN bam-12413 122 1 i i PRON bam-12413 122 2 d d NOUN bam-12413 122 3 : : PUNCT bam-12413 122 4 0009 0009 NUM bam-12413 122 5 - - SYM bam-12413 122 6 0009 0009 NUM bam-12413 122 7 - - PUNCT bam-12413 122 8 3586 3586 NUM bam-12413 122 9 - - PUNCT bam-12413 122 10 171x 171x NUM bam-12413 122 11 e e NOUN bam-12413 122 12 - - NOUN bam-12413 122 13 mail mail NOUN bam-12413 122 14 : : PUNCT bam-12413 122 15 giulia.vita@students.uniroma2.eu giulia.vita@students.uniroma2.eu ADJ bam-12413 122 16 references reference NOUN bam-12413 122 17 1 1 NUM bam-12413 122 18 . . PUNCT bam-12413 123 1 allen allen PROPN bam-12413 123 2 kd kd PROPN bam-12413 123 3 , , PUNCT bam-12413 123 4 thoma thoma PROPN bam-12413 123 5 lm lm PROPN bam-12413 123 6 , , PUNCT bam-12413 123 7 golightly golightly PROPN bam-12413 123 8 ym ym PROPN bam-12413 123 9 . . PUNCT bam-12413 123 10 epidemiology epidemiology NOUN bam-12413 123 11 of of ADP bam-12413 123 12 osteoarthritis osteoarthritis NOUN bam-12413 123 13 . . PUNCT bam-12413 124 1 osteoarthr osteoarthr ADJ bam-12413 124 2 cartilage cartilage NOUN bam-12413 124 3 2022;30:184–95 2022;30:184–95 NUM bam-12413 124 4 . . PROPN bam-12413 125 1 2 2 NUM bam-12413 125 2 . . X bam-12413 125 3 jang jang PROPN bam-12413 125 4 s s PROPN bam-12413 125 5 , , PUNCT bam-12413 125 6 lee lee PROPN bam-12413 125 7 k k PROPN bam-12413 125 8 , , PUNCT bam-12413 125 9 ju ju PROPN bam-12413 125 10 jh jh PROPN bam-12413 125 11 . . PUNCT bam-12413 126 1 recent recent ADJ bam-12413 126 2 updates update NOUN bam-12413 126 3 of of ADP bam-12413 126 4 diagnosis diagnosis NOUN bam-12413 126 5 , , PUNCT bam-12413 126 6 pathophysiology pathophysiology NOUN bam-12413 126 7 , , PUNCT bam-12413 126 8 and and CCONJ bam-12413 126 9 treatment treatment NOUN bam-12413 126 10 on on ADP bam-12413 126 11 osteoarthritis osteoarthritis NOUN bam-12413 126 12 of of ADP bam-12413 126 13 the the DET bam-12413 126 14 knee knee NOUN bam-12413 126 15 . . PUNCT bam-12413 127 1 ijms ijm VERB bam-12413 127 2 2021;22:2619 2021;22:2619 NUM bam-12413 127 3 . . PROPN bam-12413 127 4 3 3 NUM bam-12413 127 5 . . X bam-12413 127 6 dantas dantas PROPN bam-12413 127 7 lo lo PROPN bam-12413 127 8 , , PUNCT bam-12413 127 9 salvini salvini PROPN bam-12413 127 10 tdf tdf PROPN bam-12413 127 11 , , PUNCT bam-12413 127 12 mcalindon mcalindon NOUN bam-12413 127 13 te te PROPN bam-12413 127 14 . . PUNCT bam-12413 128 1 knee knee NOUN bam-12413 128 2 osteoarthritis osteoarthritis NOUN bam-12413 128 3 : : PUNCT bam-12413 128 4 key key ADJ bam-12413 128 5 treatments treatment NOUN bam-12413 128 6 and and CCONJ bam-12413 128 7 implications implication NOUN bam-12413 128 8 for for ADP bam-12413 128 9 physical physical ADJ bam-12413 128 10 therapy therapy NOUN bam-12413 128 11 . . PUNCT bam-12413 129 1 brazilian brazilian PROPN bam-12413 129 2 j j PROPN bam-12413 129 3 physical physical ADJ bam-12413 129 4 ther ther ADV bam-12413 130 1 2021;25:135–46 2021;25:135–46 NUM bam-12413 130 2 . . NOUN bam-12413 131 1 4 4 NUM bam-12413 131 2 . . X bam-12413 131 3 loeser loeser PROPN bam-12413 131 4 rf rf PROPN bam-12413 131 5 , , PUNCT bam-12413 131 6 goldring goldring PROPN bam-12413 131 7 sr sr PROPN bam-12413 131 8 , , PUNCT bam-12413 131 9 scanzello scanzello PROPN bam-12413 131 10 cr cr PROPN bam-12413 131 11 , , PUNCT bam-12413 131 12 goldring goldre VERB bam-12413 131 13 mb mb PROPN bam-12413 131 14 . . PROPN bam-12413 132 1 osteoarthritis osteoarthritis NOUN bam-12413 132 2 : : PUNCT bam-12413 132 3 a a DET bam-12413 132 4 disease disease NOUN bam-12413 132 5 of of ADP bam-12413 132 6 the the DET bam-12413 132 7 joint joint NOUN bam-12413 132 8 as as ADP bam-12413 132 9 an an DET bam-12413 132 10 organ organ NOUN bam-12413 132 11 . . PUNCT bam-12413 133 1 arthritis arthritis NOUN bam-12413 133 2 rheumatism rheumatism NOUN bam-12413 133 3 2012;64:1697–707 2012;64:1697–707 PROPN bam-12413 133 4 . . PROPN bam-12413 133 5 5 5 NUM bam-12413 133 6 . . PUNCT bam-12413 134 1 guilak guilak ADJ bam-12413 134 2 f f PROPN bam-12413 134 3 , , PUNCT bam-12413 134 4 nims nims PROPN bam-12413 134 5 rj rj PROPN bam-12413 134 6 , , PUNCT bam-12413 134 7 dicks dick VERB bam-12413 134 8 a a PRON bam-12413 134 9 , , PUNCT bam-12413 134 10 et et PROPN bam-12413 134 11 al al PROPN bam-12413 134 12 . . PUNCT bam-12413 134 13 osteoarthritis osteoarthritis NOUN bam-12413 134 14 as as ADP bam-12413 134 15 a a DET bam-12413 134 16 disease disease NOUN bam-12413 134 17 of of ADP bam-12413 134 18 the the DET bam-12413 134 19 cartilage cartilage NOUN bam-12413 134 20 pericellular pericellular ADJ bam-12413 134 21 matrix matrix NOUN bam-12413 134 22 . . PUNCT bam-12413 135 1 matrix matrix NOUN bam-12413 135 2 biol biol NOUN bam-12413 135 3 2018;71–72:40–50 2018;71–72:40–50 NUM bam-12413 135 4 . . PROPN bam-12413 135 5 6 6 NUM bam-12413 135 6 . . X bam-12413 135 7 loeser loeser PROPN bam-12413 135 8 rf rf NOUN bam-12413 135 9 . . NOUN bam-12413 135 10 aging aging NOUN bam-12413 135 11 and and CCONJ bam-12413 135 12 osteoarthritis osteoarthritis NOUN bam-12413 135 13 : : PUNCT bam-12413 135 14 the the DET bam-12413 135 15 role role NOUN bam-12413 135 16 of of ADP bam-12413 135 17 chondrocyte chondrocyte PROPN bam-12413 135 18 senescence senescence NOUN bam-12413 135 19 and and CCONJ bam-12413 135 20 aging age VERB bam-12413 135 21 changes change NOUN bam-12413 135 22 in in ADP bam-12413 135 23 the the DET bam-12413 135 24 cartilage cartilage NOUN bam-12413 135 25 matrix matrix NOUN bam-12413 135 26 . . PUNCT bam-12413 136 1 osteoarthr osteoarthr ADJ bam-12413 136 2 cartilage cartilage NOUN bam-12413 136 3 2009;17:971–9 2009;17:971–9 NUM bam-12413 136 4 . . PUNCT bam-12413 137 1 7 7 X bam-12413 137 2 . . X bam-12413 137 3 lee lee PROPN bam-12413 137 4 yc yc PROPN bam-12413 137 5 , , PUNCT bam-12413 137 6 lu lu PROPN bam-12413 137 7 b b PROPN bam-12413 137 8 , , PUNCT bam-12413 137 9 bathon bathon PROPN bam-12413 137 10 jm jm PROPN bam-12413 137 11 , , PUNCT bam-12413 137 12 et et PROPN bam-12413 137 13 al al PROPN bam-12413 137 14 . . PUNCT bam-12413 137 15 pain pain NOUN bam-12413 137 16 sensitivity sensitivity NOUN bam-12413 137 17 and and CCONJ bam-12413 137 18 pain pain NOUN bam-12413 137 19 reactivity reactivity NOUN bam-12413 137 20 in in ADP bam-12413 137 21 osteoarthritis osteoarthritis NOUN bam-12413 137 22 . . PUNCT bam-12413 138 1 arthritis arthritis NOUN bam-12413 138 2 care care NOUN bam-12413 138 3 res re VERB bam-12413 138 4 2011;63:320–7 2011;63:320–7 NUM bam-12413 138 5 . . NOUN bam-12413 139 1 8 8 NUM bam-12413 139 2 . . PUNCT bam-12413 140 1 abramoff abramoff PROPN bam-12413 140 2 b b PROPN bam-12413 140 3 , , PUNCT bam-12413 140 4 caldera caldera NOUN bam-12413 140 5 fe fe NOUN bam-12413 140 6 . . PUNCT bam-12413 140 7 osteoarthritis osteoarthritis NOUN bam-12413 140 8 . . PUNCT bam-12413 141 1 med med PROPN bam-12413 141 2 clin clin PROPN bam-12413 141 3 north north PROPN bam-12413 141 4 am be AUX bam-12413 141 5 2020;104:293–311 2020;104:293–311 NUM bam-12413 141 6 . . PUNCT bam-12413 142 1 9 9 X bam-12413 142 2 . . X bam-12413 142 3 panayotov panayotov PROPN bam-12413 142 4 k. k. PROPN bam-12413 142 5 pain pain PROPN bam-12413 142 6 treatment treatment NOUN bam-12413 142 7 . . PUNCT bam-12413 143 1 in in ADP bam-12413 143 2 : : PUNCT bam-12413 143 3 papathanasiou papathanasiou PROPN bam-12413 143 4 j j PROPN bam-12413 143 5 , , PUNCT bam-12413 143 6 panayotov panayotov PROPN bam-12413 143 7 k k PROPN bam-12413 143 8 , , PUNCT bam-12413 143 9 eds ed NOUN bam-12413 143 10 . . PUNCT bam-12413 143 11 essentials essential NOUN bam-12413 143 12 of of ADP bam-12413 143 13 physical physical ADJ bam-12413 143 14 and and CCONJ bam-12413 143 15 rehabilitation rehabilitation NOUN bam-12413 143 16 medicine medicine NOUN bam-12413 143 17 for for ADP bam-12413 143 18 undergraduate undergraduate ADJ bam-12413 143 19 medical medical ADJ bam-12413 143 20 students student NOUN bam-12413 143 21 . . PUNCT bam-12413 144 1 2nd 2nd ADJ bam-12413 144 2 ed ed NOUN bam-12413 144 3 . . PUNCT bam-12413 144 4 ruse ruse NOUN bam-12413 144 5 , , PUNCT bam-12413 144 6 bg bg NOUN bam-12413 144 7 : : PUNCT bam-12413 144 8 avangard avangard NOUN bam-12413 144 9 ; ; PUNCT bam-12413 144 10 2023 2023 NUM bam-12413 144 11 . . PUNCT bam-12413 145 1 p. p. NOUN bam-12413 145 2 229–40 229–40 NUM bam-12413 145 3 . . PUNCT bam-12413 146 1 10 10 NUM bam-12413 146 2 . . PUNCT bam-12413 147 1 katz katz PROPN bam-12413 147 2 jn jn PROPN bam-12413 147 3 , , PUNCT bam-12413 147 4 arant arant ADJ bam-12413 147 5 kr kr PROPN bam-12413 147 6 , , PUNCT bam-12413 147 7 loeser loeser NOUN bam-12413 147 8 rf rf NOUN bam-12413 147 9 . . PUNCT bam-12413 147 10 diagnosis diagnosis NOUN bam-12413 147 11 and and CCONJ bam-12413 147 12 treatment treatment NOUN bam-12413 147 13 of of ADP bam-12413 147 14 hip hip NOUN bam-12413 147 15 and and CCONJ bam-12413 147 16 knee knee NOUN bam-12413 147 17 osteoarthritis osteoarthritis NOUN bam-12413 147 18 : : PUNCT bam-12413 147 19 a a DET bam-12413 147 20 review review NOUN bam-12413 147 21 . . PUNCT bam-12413 148 1 jama jama PROPN bam-12413 148 2 2021;325:568 2021;325:568 NUM bam-12413 148 3 . . PROPN bam-12413 148 4 11 11 NUM bam-12413 148 5 . . PUNCT bam-12413 149 1 nelson nelson PROPN bam-12413 149 2 ae ae PROPN bam-12413 149 3 , , PUNCT bam-12413 149 4 allen allen PROPN bam-12413 149 5 kd kd PROPN bam-12413 149 6 , , PUNCT bam-12413 149 7 golightly golightly PROPN bam-12413 149 8 ym ym PROPN bam-12413 149 9 , , PUNCT bam-12413 149 10 et et PROPN bam-12413 149 11 al al PROPN bam-12413 149 12 . . PUNCT bam-12413 150 1 a a DET bam-12413 150 2 systematic systematic ADJ bam-12413 150 3 review review NOUN bam-12413 150 4 of of ADP bam-12413 150 5 recommendations recommendation NOUN bam-12413 150 6 and and CCONJ bam-12413 150 7 guidelines guideline NOUN bam-12413 150 8 for for ADP bam-12413 150 9 the the DET bam-12413 150 10 management management NOUN bam-12413 150 11 of of ADP bam-12413 150 12 osteoarthritis osteoarthritis NOUN bam-12413 150 13 : : PUNCT bam-12413 150 14 the the DET bam-12413 150 15 chronic chronic ADJ bam-12413 150 16 osteoarthritis osteoarthritis NOUN bam-12413 150 17 management management NOUN bam-12413 150 18 initiative initiative NOUN bam-12413 150 19 of of ADP bam-12413 150 20 the the DET bam-12413 150 21 u.s u.s PROPN bam-12413 150 22 . . PROPN bam-12413 150 23 bone bone NOUN bam-12413 150 24 and and CCONJ bam-12413 150 25 joint joint ADJ bam-12413 150 26 initiative initiative NOUN bam-12413 150 27 . . PUNCT bam-12413 151 1 semin semin PROPN bam-12413 151 2 arthritis arthritis PROPN bam-12413 151 3 rheum rheum PROPN bam-12413 151 4 2014;43:701–12 2014;43:701–12 NUM bam-12413 151 5 . . PROPN bam-12413 151 6 12 12 NUM bam-12413 151 7 . . PUNCT bam-12413 152 1 he he PRON bam-12413 152 2 z z PROPN bam-12413 152 3 , , PUNCT bam-12413 152 4 wang wang PROPN bam-12413 152 5 b b PROPN bam-12413 152 6 , , PUNCT bam-12413 152 7 hu hu PROPN bam-12413 152 8 c c NOUN bam-12413 152 9 , , PUNCT bam-12413 152 10 zhao zhao PROPN bam-12413 152 11 j. j. PROPN bam-12413 153 1 an an DET bam-12413 153 2 overview overview NOUN bam-12413 153 3 of of ADP bam-12413 153 4 hydrogel hydrogel NOUN bam-12413 153 5 - - PUNCT bam-12413 153 6 based base VERB bam-12413 153 7 intra intra ADJ bam-12413 153 8 - - ADJ bam-12413 153 9 articular articular ADJ bam-12413 153 10 drug drug NOUN bam-12413 153 11 delivery delivery NOUN bam-12413 153 12 for for ADP bam-12413 153 13 the the DET bam-12413 153 14 treatment treatment NOUN bam-12413 153 15 of of ADP bam-12413 153 16 osteoarthritis osteoarthritis NOUN bam-12413 153 17 . . PUNCT bam-12413 154 1 colloids colloid NOUN bam-12413 154 2 and and CCONJ bam-12413 154 3 surfaces surface NOUN bam-12413 154 4 b b NUM bam-12413 154 5 : : PUNCT bam-12413 154 6 biointerfaces biointerface NOUN bam-12413 154 7 2017;154:33–9 2017;154:33–9 NUM bam-12413 154 8 . . PUNCT bam-12413 155 1 13 13 NUM bam-12413 155 2 . . X bam-12413 156 1 sancesario sancesario PROPN bam-12413 156 2 a a PROPN bam-12413 156 3 , , PUNCT bam-12413 156 4 foti foti PROPN bam-12413 156 5 c. c. PROPN bam-12413 156 6 intra intra PROPN bam-12413 156 7 - - ADJ bam-12413 156 8 articular articular ADJ bam-12413 156 9 and and CCONJ bam-12413 156 10 periarticular periarticular ADJ bam-12413 156 11 injection injection NOUN bam-12413 156 12 therapy therapy NOUN bam-12413 156 13 . . PUNCT bam-12413 157 1 in in ADP bam-12413 157 2 : : PUNCT bam-12413 157 3 papathanasiou papathanasiou PROPN bam-12413 157 4 j j PROPN bam-12413 157 5 , , PUNCT bam-12413 157 6 panayotov panayotov PROPN bam-12413 157 7 k k PROPN bam-12413 157 8 , , PUNCT bam-12413 157 9 eds ed NOUN bam-12413 157 10 . . PUNCT bam-12413 157 11 essentials essential NOUN bam-12413 157 12 of of ADP bam-12413 157 13 physical physical ADJ bam-12413 157 14 and and CCONJ bam-12413 157 15 rehabilitation rehabilitation NOUN bam-12413 157 16 medicine medicine NOUN bam-12413 157 17 for for ADP bam-12413 157 18 undergraduate undergraduate ADJ bam-12413 157 19 medical medical ADJ bam-12413 157 20 students student NOUN bam-12413 157 21 . . PUNCT bam-12413 158 1 2nd 2nd ADJ bam-12413 158 2 ed ed NOUN bam-12413 158 3 . . PUNCT bam-12413 158 4 ruse ruse NOUN bam-12413 158 5 , , PUNCT bam-12413 158 6 bg bg NOUN bam-12413 158 7 : : PUNCT bam-12413 158 8 avangard avangard NOUN bam-12413 158 9 ; ; PUNCT bam-12413 158 10 2023 2023 NUM bam-12413 158 11 . . PUNCT bam-12413 159 1 p. p. NOUN bam-12413 159 2 203–18 203–18 NUM bam-12413 159 3 . . PUNCT bam-12413 159 4 14 14 NUM bam-12413 159 5 . . PUNCT bam-12413 160 1 zhao zhao PROPN bam-12413 160 2 d d PROPN bam-12413 160 3 , , PUNCT bam-12413 160 4 yu yu PROPN bam-12413 160 5 s s PROPN bam-12413 160 6 , , PUNCT bam-12413 160 7 sun sun PROPN bam-12413 160 8 b b PROPN bam-12413 160 9 , , PUNCT bam-12413 160 10 et et PROPN bam-12413 160 11 al al PROPN bam-12413 160 12 . . PROPN bam-12413 160 13 biomedical biomedical ADJ bam-12413 160 14 applications application NOUN bam-12413 160 15 of of ADP bam-12413 160 16 chitosan chitosan NOUN bam-12413 160 17 and and CCONJ bam-12413 160 18 its its PRON bam-12413 160 19 derivative derivative ADJ bam-12413 160 20 nanoparticles nanoparticle NOUN bam-12413 160 21 . . PUNCT bam-12413 161 1 polymers polymer NOUN bam-12413 161 2 2018;10:462 2018;10:462 NUM bam-12413 161 3 . . PUNCT bam-12413 161 4 15 15 NUM bam-12413 161 5 . . PUNCT bam-12413 162 1 oprenyeszk oprenyeszk PROPN bam-12413 162 2 f f PROPN bam-12413 162 3 , , PUNCT bam-12413 162 4 sanchez sanchez PROPN bam-12413 162 5 c c AUX bam-12413 162 6 , , PUNCT bam-12413 162 7 dubuc dubuc PROPN bam-12413 162 8 je je PROPN bam-12413 162 9 , , PUNCT bam-12413 162 10 et et PROPN bam-12413 162 11 al al PROPN bam-12413 162 12 . . PUNCT bam-12413 163 1 chitosan chitosan PROPN bam-12413 163 2 enriched enrich VERB bam-12413 163 3 three three NUM bam-12413 163 4 - - PUNCT bam-12413 163 5 dimensional dimensional ADJ bam-12413 163 6 matrix matrix NOUN bam-12413 163 7 reduces reduce VERB bam-12413 163 8 inflammatory inflammatory ADJ bam-12413 163 9 and and CCONJ bam-12413 163 10 catabolic catabolic ADJ bam-12413 163 11 mediators mediator NOUN bam-12413 163 12 production production NOUN bam-12413 163 13 by by ADP bam-12413 163 14 human human ADJ bam-12413 163 15 chondrocytes chondrocyte NOUN bam-12413 163 16 . . PUNCT bam-12413 164 1 plos plos PROPN bam-12413 164 2 one one NUM bam-12413 164 3 2015;10 2015;10 NUM bam-12413 164 4 : : PUNCT bam-12413 164 5 e0128362 e0128362 NUM bam-12413 164 6 . . PUNCT bam-12413 165 1 16 16 NUM bam-12413 165 2 . . PUNCT bam-12413 166 1 chien chien PROPN bam-12413 166 2 rc rc PROPN bam-12413 166 3 , , PUNCT bam-12413 166 4 yen yen PROPN bam-12413 166 5 mt mt PROPN bam-12413 166 6 , , PUNCT bam-12413 166 7 mau mau PROPN bam-12413 166 8 jl jl PROPN bam-12413 166 9 . . PROPN bam-12413 167 1 antimicrobial antimicrobial ADJ bam-12413 167 2 and and CCONJ bam-12413 167 3 antitumor antitumor NOUN bam-12413 167 4 activities activity NOUN bam-12413 167 5 of of ADP bam-12413 167 6 chitosan chitosan NOUN bam-12413 167 7 from from ADP bam-12413 167 8 shiitake shiitake PROPN bam-12413 167 9 stipes stipes PROPN bam-12413 167 10 , , PUNCT bam-12413 167 11 compared compare VERB bam-12413 167 12 to to ADP bam-12413 167 13 commercial commercial ADJ bam-12413 167 14 chitosan chitosan NOUN bam-12413 167 15 from from ADP bam-12413 167 16 crab crab NOUN bam-12413 167 17 shells shell NOUN bam-12413 167 18 . . PUNCT bam-12413 168 1 carbohydrate carbohydrate VERB bam-12413 168 2 polymers polymer NOUN bam-12413 168 3 2016;138:259–64 2016;138:259–64 PROPN bam-12413 168 4 . . PROPN bam-12413 168 5 17 17 NUM bam-12413 168 6 . . PUNCT bam-12413 169 1 busilacchi busilacchi VERB bam-12413 169 2 a a PRON bam-12413 169 3 , , PUNCT bam-12413 169 4 gigante gigante PROPN bam-12413 169 5 a a PRON bam-12413 169 6 , , PUNCT bam-12413 169 7 mattioli mattioli PROPN bam-12413 169 8 - - PUNCT bam-12413 169 9 belmonte belmonte PROPN bam-12413 169 10 m m PROPN bam-12413 169 11 , , PUNCT bam-12413 169 12 manzotti manzotti PROPN bam-12413 169 13 s s PROPN bam-12413 169 14 , , PUNCT bam-12413 169 15 muzzarelli muzzarelli ADJ bam-12413 169 16 raa raa NOUN bam-12413 169 17 . . PUNCT bam-12413 170 1 chitosan chitosan PROPN bam-12413 170 2 stabilizes stabilize VERB bam-12413 170 3 platelet platelet NOUN bam-12413 170 4 growth growth NOUN bam-12413 170 5 factors factor NOUN bam-12413 170 6 and and CCONJ bam-12413 170 7 modulates modulate NOUN bam-12413 170 8 stem stem VERB bam-12413 170 9 cell cell NOUN bam-12413 170 10 differentiation differentiation NOUN bam-12413 170 11 toward toward ADP bam-12413 170 12 tissue tissue NOUN bam-12413 170 13 regeneration regeneration NOUN bam-12413 170 14 . . PUNCT bam-12413 171 1 carbohydrate carbohydrate NOUN bam-12413 171 2 polymers polymer NOUN bam-12413 171 3 2013;98:665–76 2013;98:665–76 NUM bam-12413 171 4 . . PROPN bam-12413 171 5 18 18 NUM bam-12413 171 6 . . PUNCT bam-12413 172 1 ngo ngo PROPN bam-12413 172 2 dh dh PROPN bam-12413 172 3 , , PUNCT bam-12413 172 4 kim kim PROPN bam-12413 172 5 sk sk PROPN bam-12413 172 6 . . PROPN bam-12413 172 7 antioxidant antioxidant ADJ bam-12413 172 8 effects effect NOUN bam-12413 172 9 of of ADP bam-12413 172 10 chitin chitin NOUN bam-12413 172 11 , , PUNCT bam-12413 172 12 chitosan chitosan NOUN bam-12413 172 13 , , PUNCT bam-12413 172 14 and and CCONJ bam-12413 172 15 their their PRON bam-12413 172 16 derivatives derivative NOUN bam-12413 172 17 . . PUNCT bam-12413 173 1 adv adv PROPN bam-12413 173 2 food food NOUN bam-12413 173 3 nutrition nutrition NOUN bam-12413 173 4 res re NOUN bam-12413 173 5 2014:73:15–31 2014:73:15–31 NUM bam-12413 173 6 . . PUNCT bam-12413 174 1 19 19 NUM bam-12413 174 2 . . PUNCT bam-12413 174 3 cheung cheung PROPN bam-12413 174 4 r r PROPN bam-12413 174 5 , , PUNCT bam-12413 174 6 ng ng PROPN bam-12413 174 7 t t PROPN bam-12413 174 8 , , PUNCT bam-12413 174 9 wong wong PROPN bam-12413 174 10 j j PROPN bam-12413 174 11 , , PUNCT bam-12413 174 12 chan chan PROPN bam-12413 174 13 w. w. PROPN bam-12413 174 14 chitosan chitosan PROPN bam-12413 174 15 : : PUNCT bam-12413 174 16 an an DET bam-12413 174 17 update update NOUN bam-12413 174 18 on on ADP bam-12413 174 19 potential potential ADJ bam-12413 174 20 biomedical biomedical ADJ bam-12413 174 21 and and CCONJ bam-12413 174 22 pharmaceutical pharmaceutical NOUN bam-12413 174 23 applications application NOUN bam-12413 174 24 . . PUNCT bam-12413 175 1 marine marine ADJ bam-12413 175 2 drugs drug NOUN bam-12413 175 3 2015;13:5156–86 2015;13:5156–86 NUM bam-12413 175 4 . . PROPN bam-12413 175 5 20 20 NUM bam-12413 175 6 . . PUNCT bam-12413 176 1 kaderli kaderli PROPN bam-12413 176 2 s s PROPN bam-12413 176 3 , , PUNCT bam-12413 176 4 viguier viguier PROPN bam-12413 176 5 e e NOUN bam-12413 176 6 , , PUNCT bam-12413 176 7 watrelot watrelot NOUN bam-12413 176 8 - - PUNCT bam-12413 176 9 virieux virieux NOUN bam-12413 176 10 d d PROPN bam-12413 176 11 , , PUNCT bam-12413 176 12 et et PROPN bam-12413 176 13 al al PROPN bam-12413 176 14 . . PROPN bam-12413 177 1 efficacy efficacy NOUN bam-12413 177 2 study study NOUN bam-12413 177 3 of of ADP bam-12413 177 4 two two NUM bam-12413 177 5 novel novel ADJ bam-12413 177 6 hyaluronic hyaluronic ADJ bam-12413 177 7 acid acid NOUN bam-12413 177 8 - - PUNCT bam-12413 177 9 based base VERB bam-12413 177 10 formulations formulation NOUN bam-12413 177 11 for for ADP bam-12413 177 12 viscosupplementation viscosupplementation NOUN bam-12413 177 13 therapy therapy NOUN bam-12413 177 14 in in ADP bam-12413 177 15 an an DET bam-12413 177 16 early early ADJ bam-12413 177 17 osteoarthrosic osteoarthrosic ADJ bam-12413 177 18 rabbit rabbit NOUN bam-12413 177 19 model model NOUN bam-12413 177 20 . . PUNCT bam-12413 178 1 eu eu PROPN bam-12413 178 2 j j PROPN bam-12413 178 3 pharmaceut pharmaceut PROPN bam-12413 178 4 biopharmaceut biopharmaceut VERB bam-12413 178 5 2015;96:388–95 2015;96:388–95 NUM bam-12413 178 6 . . PUNCT bam-12413 179 1 21 21 NUM bam-12413 179 2 . . PUNCT bam-12413 180 1 kaderli kaderli PROPN bam-12413 180 2 s s PROPN bam-12413 180 3 , , PUNCT bam-12413 180 4 boulocher boulocher X bam-12413 180 5 c c NOUN bam-12413 180 6 , , PUNCT bam-12413 180 7 pillet pillet NOUN bam-12413 180 8 e e NOUN bam-12413 180 9 , , PUNCT bam-12413 180 10 et et PROPN bam-12413 180 11 al al PROPN bam-12413 180 12 . . PUNCT bam-12413 181 1 a a DET bam-12413 181 2 novel novel ADJ bam-12413 181 3 biocompatible biocompatible ADJ bam-12413 181 4 hyaluronic hyaluronic ADJ bam-12413 181 5 acid acid NOUN bam-12413 181 6 – – PUNCT bam-12413 181 7 chitosan chitosan ADJ bam-12413 181 8 hybrid hybrid ADJ bam-12413 181 9 hydrogel hydrogel NOUN bam-12413 181 10 for for ADP bam-12413 181 11 osteoarthrosis osteoarthrosis NOUN bam-12413 181 12 therapy therapy NOUN bam-12413 181 13 . . PUNCT bam-12413 182 1 int int PROPN bam-12413 182 2 j j PROPN bam-12413 182 3 pharmaceut pharmaceut VERB bam-12413 182 4 2015 2015 NUM bam-12413 182 5 ; ; PUNCT bam-12413 182 6 483:158–68 483:158–68 NUM bam-12413 182 7 . . PUNCT bam-12413 183 1 22 22 NUM bam-12413 183 2 . . PUNCT bam-12413 184 1 patchornik patchornik PROPN bam-12413 184 2 s s PROPN bam-12413 184 3 , , PUNCT bam-12413 184 4 ram ram PROPN bam-12413 184 5 e e NOUN bam-12413 184 6 , , PUNCT bam-12413 184 7 ben ben PROPN bam-12413 184 8 shalom shalom PROPN bam-12413 184 9 n n CCONJ bam-12413 184 10 , , PUNCT bam-12413 184 11 et et PROPN bam-12413 184 12 al al PROPN bam-12413 184 13 . . PROPN bam-12413 184 14 chitosanhyaluronate chitosanhyaluronate VERB bam-12413 184 15 hybrid hybrid NOUN bam-12413 184 16 gel gel NOUN bam-12413 184 17 intraarticular intraarticular NOUN bam-12413 184 18 injection injection NOUN bam-12413 184 19 delays delay VERB bam-12413 184 20 osteoarthritis osteoarthritis NOUN bam-12413 184 21 progression progression NOUN bam-12413 184 22 and and CCONJ bam-12413 184 23 reduces reduce VERB bam-12413 184 24 pain pain NOUN bam-12413 184 25 in in ADP bam-12413 184 26 a a DET bam-12413 184 27 rat rat NOUN bam-12413 184 28 meniscectomy meniscectomy NOUN bam-12413 184 29 model model NOUN bam-12413 184 30 as as ADP bam-12413 184 31 compared compare VERB bam-12413 184 32 to to AUX bam-12413 184 33 saline saline VERB bam-12413 184 34 and and CCONJ bam-12413 184 35 hyaluronate hyaluronate ADJ bam-12413 184 36 treatment treatment NOUN bam-12413 184 37 . . PUNCT bam-12413 185 1 adv adv PROPN bam-12413 185 2 orthoped orthope VERB bam-12413 185 3 2012;2012:1–5 2012;2012:1–5 NUM bam-12413 185 4 . . PUNCT bam-12413 186 1 23 23 NUM bam-12413 186 2 . . PUNCT bam-12413 187 1 douette douette NOUN bam-12413 187 2 p p PROPN bam-12413 187 3 , , PUNCT bam-12413 187 4 chausson chausson PROPN bam-12413 187 5 m m PROPN bam-12413 187 6 , , PUNCT bam-12413 187 7 theatre theatre NOUN bam-12413 187 8 e e NOUN bam-12413 187 9 , , PUNCT bam-12413 187 10 et et PROPN bam-12413 187 11 al al PROPN bam-12413 187 12 . . PUNCT bam-12413 187 13 biological biological ADJ bam-12413 187 14 safety safety NOUN bam-12413 187 15 evaluation evaluation NOUN bam-12413 187 16 of of ADP bam-12413 187 17 kiomedine kiomedine NOUN bam-12413 187 18 ® ® NOUN bam-12413 187 19 cm cm NOUN bam-12413 187 20 - - PUNCT bam-12413 187 21 chitosan chitosan NOUN bam-12413 187 22 , , PUNCT bam-12413 187 23 an an DET bam-12413 187 24 innovative innovative ADJ bam-12413 187 25 non non ADJ bam-12413 187 26 - - ADJ bam-12413 187 27 animal animal ADJ bam-12413 187 28 carboxymethyl carboxymethyl NOUN bam-12413 187 29 - - PUNCT bam-12413 187 30 chitosan chitosan NOUN bam-12413 187 31 biomaterial biomaterial NOUN bam-12413 187 32 intended intend VERB bam-12413 187 33 for for ADP bam-12413 187 34 injectable injectable ADJ bam-12413 187 35 biomedical biomedical ADJ bam-12413 187 36 applications application NOUN bam-12413 187 37 . . PUNCT bam-12413 188 1 jb jb PROPN bam-12413 188 2 2020;4:39 2020;4:39 PROPN bam-12413 188 3 . . PUNCT bam-12413 189 1 24 24 NUM bam-12413 189 2 . . PUNCT bam-12413 190 1 li li PROPN bam-12413 190 2 h h PROPN bam-12413 190 3 , , PUNCT bam-12413 190 4 xu xu PROPN bam-12413 191 1 q q X bam-12413 191 2 , , PUNCT bam-12413 191 3 chen chen PROPN bam-12413 191 4 y y PROPN bam-12413 191 5 , , PUNCT bam-12413 191 6 wan wan PROPN bam-12413 191 7 a. a. NOUN bam-12413 191 8 effect effect NOUN bam-12413 191 9 of of ADP bam-12413 191 10 concentration concentration NOUN bam-12413 191 11 and and CCONJ bam-12413 191 12 molecular molecular ADJ bam-12413 191 13 weight weight NOUN bam-12413 191 14 of of ADP bam-12413 191 15 chitosan chitosan NOUN bam-12413 191 16 and and CCONJ bam-12413 191 17 its its PRON bam-12413 191 18 derivative derivative NOUN bam-12413 191 19 on on ADP bam-12413 191 20 the the DET bam-12413 191 21 free free ADJ bam-12413 191 22 radical radical ADJ bam-12413 191 23 scavenging scavenging NOUN bam-12413 191 24 ability ability NOUN bam-12413 191 25 . . PUNCT bam-12413 192 1 j j PROPN bam-12413 192 2 biomed biome VERB bam-12413 192 3 materials material NOUN bam-12413 192 4 res re NOUN bam-12413 192 5 2014;102:911–6 2014;102:911–6 NUM bam-12413 192 6 . . PUNCT bam-12413 193 1 25 25 NUM bam-12413 193 2 . . PUNCT bam-12413 193 3 vandeweerd vandeweerd PROPN bam-12413 193 4 jm jm PROPN bam-12413 193 5 , , PUNCT bam-12413 193 6 innocenti innocenti PROPN bam-12413 193 7 b b PROPN bam-12413 193 8 , , PUNCT bam-12413 193 9 rocasalbas rocasalbas VERB bam-12413 193 10 g g NOUN bam-12413 193 11 , , PUNCT bam-12413 193 12 et et PROPN bam-12413 193 13 al al PROPN bam-12413 193 14 . . PUNCT bam-12413 194 1 non non ADJ bam-12413 194 2 - - ADJ bam-12413 194 3 clinical clinical ADJ bam-12413 194 4 assessment assessment NOUN bam-12413 194 5 of of ADP bam-12413 194 6 lubrication lubrication NOUN bam-12413 194 7 and and CCONJ bam-12413 194 8 free free ADJ bam-12413 194 9 radical radical ADJ bam-12413 194 10 scavenging scavenging NOUN bam-12413 194 11 of of ADP bam-12413 194 12 an an DET bam-12413 194 13 innovative innovative ADJ bam-12413 194 14 non non ADJ bam-12413 194 15 - - ADJ bam-12413 194 16 animal animal ADJ bam-12413 194 17 carboxymethyl carboxymethyl NOUN bam-12413 194 18 chitosan chitosan NOUN bam-12413 194 19 biomaterial biomaterial NOUN bam-12413 194 20 for for ADP bam-12413 194 21 viscosupplementation viscosupplementation NOUN bam-12413 194 22 : : PUNCT bam-12413 194 23 an an DET bam-12413 194 24 in in ADV bam-12413 194 25 - - PUNCT bam-12413 194 26 vitro vitro X bam-12413 194 27 and and CCONJ bam-12413 194 28 ex ex ADJ bam-12413 194 29 - - ADJ bam-12413 194 30 vivo vivo ADJ bam-12413 194 31 study study NOUN bam-12413 194 32 . . PUNCT bam-12413 195 1 plos plos PROPN bam-12413 195 2 one one NUM bam-12413 195 3 2021;16 2021;16 NUM bam-12413 195 4 : : PUNCT bam-12413 195 5 e0256770 e0256770 NOUN bam-12413 195 6 . . NOUN bam-12413 196 1 26 26 NUM bam-12413 196 2 . . PUNCT bam-12413 196 3 emans emans PROPN bam-12413 196 4 pj pj PROPN bam-12413 196 5 , , PUNCT bam-12413 196 6 skaliczki skaliczki VERB bam-12413 196 7 g g PROPN bam-12413 196 8 , , PUNCT bam-12413 196 9 haverkamp haverkamp PROPN bam-12413 196 10 d d PROPN bam-12413 196 11 , , PUNCT bam-12413 196 12 et et PROPN bam-12413 196 13 al al PROPN bam-12413 196 14 . . PUNCT bam-12413 197 1 first first ADJ bam-12413 197 2 - - PUNCT bam-12413 197 3 in37 in37 PROPN bam-12413 197 4 non non ADJ bam-12413 197 5 -co -co ADJ bam-12413 197 6 mmerc mmerc PROPN bam-12413 197 7 ial ial PROPN bam-12413 197 8 us us PROPN bam-12413 197 9 e e NOUN bam-12413 197 10 o o PROPN bam-12413 197 11 nly nly ADV bam-12413 197 12 mailto:foti@med.uniroma2.it mailto:foti@med.uniroma2.it DET bam-12413 197 13 mailto mailto NOUN bam-12413 197 14 : : PUNCT bam-12413 197 15 nicola.manocchio@uniroma2 nicola.manocchio@uniroma2 X bam-12413 197 16 . . PUNCT bam-12413 198 1 mailto:concetta.ljoka@ptvonline.it mailto:concetta.ljoka@ptvonline.it PROPN bam-12413 198 2 mailto:nicolo.piacentini@students.uniroma2.eu mailto:nicolo.piacentini@students.uniroma2.eu NOUN bam-12413 198 3 mailto:sorge@uniroma2.it mailto:sorge@uniroma2.it PROPN bam-12413 198 4 mailto:giulia.vita@students.uniroma2.eu mailto:giulia.vita@students.uniroma2.eu NOUN bam-12413 198 5 intra intra ADJ bam-12413 198 6 - - ADJ bam-12413 198 7 articular articular ADJ bam-12413 198 8 injections injection NOUN bam-12413 198 9 with with ADP bam-12413 198 10 cmc cmc NOUN bam-12413 198 11 in in ADP bam-12413 198 12 patients patient NOUN bam-12413 198 13 affected affect VERB bam-12413 198 14 by by ADP bam-12413 198 15 knee knee NOUN bam-12413 198 16 oa oa PROPN bam-12413 198 17 in in ADP bam-12413 198 18 non non NOUN bam-12413 198 19 - - NOUN bam-12413 198 20 responders responder NOUN bam-12413 198 21 to to PART bam-12413 198 22 hyaluronic hyaluronic VERB bam-12413 198 23 acid acid NOUN bam-12413 198 24 eur eur PROPN bam-12413 198 25 j j PROPN bam-12413 198 26 transl transl PROPN bam-12413 198 27 myol myol NOUN bam-12413 198 28 34 34 NUM bam-12413 198 29 ( ( PUNCT bam-12413 198 30 3 3 NUM bam-12413 198 31 ) ) PUNCT bam-12413 198 32 12413 12413 NUM bam-12413 198 33 , , PUNCT bam-12413 198 34 2024 2024 NUM bam-12413 198 35 doi doi NOUN bam-12413 198 36 : : PUNCT bam-12413 198 37 10.4081 10.4081 NUM bam-12413 198 38 / / SYM bam-12413 198 39 ejtm.2024.12413 ejtm.2024.12413 PROPN bam-12413 198 40 human human ADJ bam-12413 198 41 study study NOUN bam-12413 198 42 to to PART bam-12413 198 43 evaluate evaluate VERB bam-12413 198 44 a a DET bam-12413 198 45 single single ADJ bam-12413 198 46 injection injection NOUN bam-12413 198 47 of of ADP bam-12413 198 48 kiomedine kiomedine NOUN bam-12413 198 49 ® ® NOUN bam-12413 198 50 cm cm NOUN bam-12413 198 51 - - PUNCT bam-12413 198 52 chitosan chitosan NOUN bam-12413 198 53 for for ADP bam-12413 198 54 treating treat VERB bam-12413 198 55 symptomatic symptomatic ADJ bam-12413 198 56 knee knee NOUN bam-12413 198 57 osteoarthritis osteoarthritis NOUN bam-12413 198 58 . . PUNCT bam-12413 199 1 torj torj PROPN bam-12413 199 2 2022;16 2022;16 NUM bam-12413 199 3 : : PUNCT bam-12413 199 4 e187431292206100 e187431292206100 PROPN bam-12413 199 5 . . PUNCT bam-12413 200 1 27 27 NUM bam-12413 200 2 . . PUNCT bam-12413 200 3 mavrov mavrov NOUN bam-12413 200 4 m. m. NOUN bam-12413 200 5 the the DET bam-12413 200 6 law law PROPN bam-12413 200 7 institute institute PROPN bam-12413 200 8 of of ADP bam-12413 200 9 patient patient PROPN bam-12413 200 10 ’s ’s PART bam-12413 200 11 informed inform VERB bam-12413 200 12 consent consent NOUN bam-12413 200 13 . . PUNCT bam-12413 201 1 publishing publish VERB bam-12413 201 2 house house PROPN bam-12413 201 3 stovi stovi PROPN bam-12413 201 4 group group PROPN bam-12413 201 5 bulgaria bulgaria PROPN bam-12413 201 6 . . PUNCT bam-12413 202 1 2018;17–8 2018;17–8 NUM bam-12413 202 2 . . NOUN bam-12413 202 3 28 28 NUM bam-12413 202 4 . . PUNCT bam-12413 203 1 kohn kohn PROPN bam-12413 203 2 md md PROPN bam-12413 203 3 , , PUNCT bam-12413 203 4 sassoon sassoon PROPN bam-12413 203 5 aa aa PROPN bam-12413 203 6 , , PUNCT bam-12413 203 7 fernando fernando PROPN bam-12413 203 8 nd nd PROPN bam-12413 203 9 . . PROPN bam-12413 203 10 classifications classification NOUN bam-12413 203 11 in in ADP bam-12413 203 12 brief brief NOUN bam-12413 203 13 : : PUNCT bam-12413 203 14 kellgren kellgren ADJ bam-12413 203 15 - - PUNCT bam-12413 203 16 lawrence lawrence NOUN bam-12413 203 17 classification classification NOUN bam-12413 203 18 of of ADP bam-12413 203 19 osteoarthritis osteoarthritis NOUN bam-12413 203 20 . . PUNCT bam-12413 204 1 clin clin PROPN bam-12413 204 2 orthopaed orthopae VERB bam-12413 204 3 related relate VERB bam-12413 204 4 res re NOUN bam-12413 204 5 2016;474 2016;474 NUM bam-12413 204 6 : : PUNCT bam-12413 205 1 1886–93 1886–93 NUM bam-12413 205 2 . . PUNCT bam-12413 206 1 29 29 NUM bam-12413 206 2 . . PUNCT bam-12413 207 1 scott scott PROPN bam-12413 207 2 j j PROPN bam-12413 207 3 , , PUNCT bam-12413 207 4 huskisson huskisson PROPN bam-12413 207 5 ec ec PROPN bam-12413 207 6 . . PUNCT bam-12413 207 7 graphic graphic ADJ bam-12413 207 8 representation representation NOUN bam-12413 207 9 of of ADP bam-12413 207 10 pain pain NOUN bam-12413 207 11 . . PUNCT bam-12413 208 1 pain pain NOUN bam-12413 208 2 1976;2:175–84 1976;2:175–84 NOUN bam-12413 208 3 . . PUNCT bam-12413 209 1 30 30 NUM bam-12413 209 2 . . PUNCT bam-12413 210 1 hawker hawker PROPN bam-12413 210 2 ga ga PROPN bam-12413 210 3 , , PUNCT bam-12413 210 4 mian mian PROPN bam-12413 210 5 s s PROPN bam-12413 210 6 , , PUNCT bam-12413 210 7 kendzerska kendzerska PROPN bam-12413 210 8 t t PROPN bam-12413 210 9 , , PUNCT bam-12413 210 10 french french ADJ bam-12413 210 11 m. m. NOUN bam-12413 210 12 measures measure NOUN bam-12413 210 13 of of ADP bam-12413 210 14 adult adult NOUN bam-12413 210 15 pain pain NOUN bam-12413 210 16 : : PUNCT bam-12413 210 17 visual visual ADJ bam-12413 210 18 analog analog NOUN bam-12413 210 19 scale scale NOUN bam-12413 210 20 for for ADP bam-12413 210 21 pain pain NOUN bam-12413 210 22 ( ( PUNCT bam-12413 210 23 vas vas X bam-12413 210 24 pain pain NOUN bam-12413 210 25 ) ) PUNCT bam-12413 210 26 , , PUNCT bam-12413 210 27 numeric numeric ADJ bam-12413 210 28 rating rating NOUN bam-12413 210 29 scale scale NOUN bam-12413 210 30 for for ADP bam-12413 210 31 pain pain NOUN bam-12413 210 32 ( ( PUNCT bam-12413 210 33 nrs nrs NOUN bam-12413 210 34 pain pain NOUN bam-12413 210 35 ) ) PUNCT bam-12413 210 36 , , PUNCT bam-12413 210 37 mcgill mcgill PROPN bam-12413 210 38 pain pain NOUN bam-12413 210 39 questionnaire questionnaire NOUN bam-12413 210 40 ( ( PUNCT bam-12413 210 41 mpq mpq X bam-12413 210 42 ) ) PUNCT bam-12413 210 43 , , PUNCT bam-12413 210 44 short short ADJ bam-12413 210 45 - - PUNCT bam-12413 210 46 form form NOUN bam-12413 210 47 mcgill mcgill NOUN bam-12413 210 48 pain pain NOUN bam-12413 210 49 questionnaire questionnaire NOUN bam-12413 210 50 ( ( PUNCT bam-12413 210 51 sf sf NOUN bam-12413 210 52 - - PUNCT bam-12413 210 53 mpq mpq NOUN bam-12413 210 54 ) ) PUNCT bam-12413 210 55 , , PUNCT bam-12413 210 56 chronic chronic ADJ bam-12413 210 57 pain pain NOUN bam-12413 210 58 grade grade NOUN bam-12413 210 59 scale scale NOUN bam-12413 210 60 ( ( PUNCT bam-12413 210 61 cpgs cpgs NOUN bam-12413 210 62 ) ) PUNCT bam-12413 210 63 , , PUNCT bam-12413 210 64 short short ADJ bam-12413 210 65 form-36 form-36 PROPN bam-12413 210 66 bodily bodily ADV bam-12413 210 67 pain pain NOUN bam-12413 210 68 scale scale NOUN bam-12413 210 69 ( ( PUNCT bam-12413 210 70 sf36 sf36 PROPN bam-12413 210 71 bps bps PROPN bam-12413 210 72 ) ) PUNCT bam-12413 210 73 , , PUNCT bam-12413 210 74 and and CCONJ bam-12413 210 75 measure measure NOUN bam-12413 210 76 of of ADP bam-12413 210 77 intermittent intermittent ADJ bam-12413 210 78 and and CCONJ bam-12413 210 79 constant constant ADJ bam-12413 210 80 osteoarthritis osteoarthritis NOUN bam-12413 210 81 pain pain NOUN bam-12413 210 82 ( ( PUNCT bam-12413 210 83 icoap icoap PROPN bam-12413 210 84 ) ) PUNCT bam-12413 210 85 . . PUNCT bam-12413 211 1 arthritis arthritis NOUN bam-12413 211 2 care care NOUN bam-12413 211 3 res re VERB bam-12413 211 4 2011;63:20543 2011;63:20543 NUM bam-12413 211 5 31 31 NUM bam-12413 211 6 . . PUNCT bam-12413 212 1 monticone monticone PROPN bam-12413 212 2 m m PROPN bam-12413 212 3 , , PUNCT bam-12413 212 4 ferrante ferrante PROPN bam-12413 212 5 s s PROPN bam-12413 212 6 , , PUNCT bam-12413 212 7 salvaderi salvaderi PROPN bam-12413 212 8 s s PROPN bam-12413 212 9 , , PUNCT bam-12413 212 10 et et PROPN bam-12413 212 11 al al PROPN bam-12413 212 12 . . PUNCT bam-12413 212 13 development development NOUN bam-12413 212 14 of of ADP bam-12413 212 15 the the DET bam-12413 212 16 italian italian ADJ bam-12413 212 17 version version NOUN bam-12413 212 18 of of ADP bam-12413 212 19 the the DET bam-12413 212 20 knee knee NOUN bam-12413 212 21 injury injury NOUN bam-12413 212 22 and and CCONJ bam-12413 212 23 osteoarthritis osteoarthritis NOUN bam-12413 212 24 outcome outcome NOUN bam-12413 212 25 score score NOUN bam-12413 212 26 for for ADP bam-12413 212 27 patients patient NOUN bam-12413 212 28 with with ADP bam-12413 212 29 knee knee NOUN bam-12413 212 30 injuries injury NOUN bam-12413 212 31 : : PUNCT bam-12413 212 32 cross cross ADJ bam-12413 212 33 - - ADJ bam-12413 212 34 cultural cultural ADJ bam-12413 212 35 adaptation adaptation NOUN bam-12413 212 36 , , PUNCT bam-12413 212 37 dimensionality dimensionality NOUN bam-12413 212 38 , , PUNCT bam-12413 212 39 reliability reliability NOUN bam-12413 212 40 , , PUNCT bam-12413 212 41 and and CCONJ bam-12413 212 42 validity validity NOUN bam-12413 212 43 . . PUNCT bam-12413 213 1 osteoarthritis osteoarthritis NOUN bam-12413 213 2 cartilage cartilage NOUN bam-12413 213 3 2012;20:330–5 2012;20:330–5 NUM bam-12413 213 4 . . PUNCT bam-12413 214 1 32 32 NUM bam-12413 214 2 . . PUNCT bam-12413 215 1 kolmogorov kolmogorov PROPN bam-12413 215 2 – – PUNCT bam-12413 215 3 smirnov smirnov ADJ bam-12413 215 4 test test NOUN bam-12413 215 5 . . PUNCT bam-12413 216 1 in in ADP bam-12413 216 2 : : PUNCT bam-12413 216 3 the the DET bam-12413 216 4 concise concise ADJ bam-12413 216 5 encyclopedia encyclopedia NOUN bam-12413 216 6 of of ADP bam-12413 216 7 statistics statistic NOUN bam-12413 217 1 [ [ X bam-12413 217 2 internet internet NOUN bam-12413 217 3 ] ] PUNCT bam-12413 217 4 . . PUNCT bam-12413 218 1 new new PROPN bam-12413 218 2 york york PROPN bam-12413 218 3 , , PUNCT bam-12413 218 4 ny ny PROPN bam-12413 218 5 : : PUNCT bam-12413 218 6 springer springer PROPN bam-12413 218 7 new new PROPN bam-12413 218 8 york york PROPN bam-12413 218 9 ; ; PUNCT bam-12413 218 10 2008 2008 NUM bam-12413 219 1 [ [ X bam-12413 219 2 cited cite VERB bam-12413 219 3 2024 2024 NUM bam-12413 219 4 feb feb NOUN bam-12413 219 5 16 16 NUM bam-12413 219 6 ] ] PUNCT bam-12413 219 7 . . PUNCT bam-12413 220 1 p. p. NOUN bam-12413 220 2 283–7 283–7 NUM bam-12413 220 3 . . PUNCT bam-12413 221 1 available available ADJ bam-12413 221 2 from from ADP bam-12413 221 3 : : PUNCT bam-12413 221 4 http://link.springer.com/10.1007/978-0-38732833-1_214 http://link.springer.com/10.1007/978-0-38732833-1_214 PROPN bam-12413 221 5 33 33 NUM bam-12413 221 6 . . PUNCT bam-12413 222 1 haynes haynes PROPN bam-12413 222 2 w. w. PROPN bam-12413 222 3 bonferroni bonferroni PROPN bam-12413 222 4 correction correction NOUN bam-12413 222 5 . . PUNCT bam-12413 223 1 in in ADP bam-12413 223 2 : : PUNCT bam-12413 223 3 dubitzky dubitzky PROPN bam-12413 223 4 w w PROPN bam-12413 223 5 , , PUNCT bam-12413 223 6 wolkenhauer wolkenhauer ADJ bam-12413 223 7 o o NOUN bam-12413 223 8 , , PUNCT bam-12413 223 9 cho cho PROPN bam-12413 223 10 kh kh PROPN bam-12413 223 11 , , PUNCT bam-12413 223 12 yokota yokota PROPN bam-12413 223 13 h h NOUN bam-12413 223 14 , , PUNCT bam-12413 223 15 editors editor NOUN bam-12413 223 16 . . PUNCT bam-12413 224 1 encyclopedia encyclopedia NOUN bam-12413 224 2 of of ADP bam-12413 224 3 systems system NOUN bam-12413 224 4 biology biology NOUN bam-12413 224 5 [ [ X bam-12413 224 6 internet internet NOUN bam-12413 224 7 ] ] PUNCT bam-12413 224 8 . . PUNCT bam-12413 225 1 new new PROPN bam-12413 225 2 york york PROPN bam-12413 225 3 , , PUNCT bam-12413 225 4 ny ny PROPN bam-12413 225 5 : : PUNCT bam-12413 225 6 springer springer PROPN bam-12413 225 7 new new PROPN bam-12413 225 8 york york PROPN bam-12413 225 9 ; ; PUNCT bam-12413 225 10 2013 2013 NUM bam-12413 225 11 [ [ X bam-12413 225 12 cited cite VERB bam-12413 225 13 2024 2024 NUM bam-12413 225 14 feb feb NOUN bam-12413 225 15 16 16 NUM bam-12413 225 16 ] ] PUNCT bam-12413 225 17 . . PUNCT bam-12413 226 1 p. p. NOUN bam-12413 226 2 154–154 154–154 NUM bam-12413 226 3 . . PUNCT bam-12413 227 1 available available ADJ bam-12413 227 2 from from ADP bam-12413 227 3 : : PUNCT bam-12413 227 4 http://link.springer.com/10.1007/978-14419-9863-7_1213 http://link.springer.com/10.1007/978-14419-9863-7_1213 PROPN bam-12413 227 5 34 34 NUM bam-12413 227 6 . . PUNCT bam-12413 228 1 muhammad muhammad PROPN bam-12413 228 2 ln ln PROPN bam-12413 228 3 . . PUNCT bam-12413 228 4 guidelines guideline NOUN bam-12413 228 5 for for ADP bam-12413 228 6 repeated repeat VERB bam-12413 228 7 measures measure NOUN bam-12413 228 8 statistical statistical ADJ bam-12413 228 9 analysis analysis NOUN bam-12413 228 10 approaches approach NOUN bam-12413 228 11 with with ADP bam-12413 228 12 basic basic ADJ bam-12413 228 13 science science NOUN bam-12413 228 14 research research NOUN bam-12413 228 15 considerations consideration NOUN bam-12413 228 16 . . PUNCT bam-12413 229 1 journal journal NOUN bam-12413 229 2 of of ADP bam-12413 229 3 clinical clinical ADJ bam-12413 229 4 investigation investigation NOUN bam-12413 229 5 2023 2023 NUM bam-12413 229 6 ; ; PUNCT bam-12413 229 7 133 133 NUM bam-12413 229 8 : : SYM bam-12413 229 9 e171058 e171058 NUM bam-12413 229 10 . . PROPN bam-12413 229 11 35 35 NUM bam-12413 229 12 . . PUNCT bam-12413 230 1 bannuru bannuru PROPN bam-12413 230 2 rr rr PROPN bam-12413 230 3 , , PUNCT bam-12413 230 4 osani osani PROPN bam-12413 230 5 mc mc PROPN bam-12413 230 6 , , PUNCT bam-12413 230 7 vaysbrot vaysbrot PROPN bam-12413 230 8 ee ee PROPN bam-12413 230 9 , , PUNCT bam-12413 230 10 et et PROPN bam-12413 230 11 al al PROPN bam-12413 230 12 . . PROPN bam-12413 230 13 oarsi oarsi ADJ bam-12413 230 14 guidelines guideline NOUN bam-12413 230 15 for for ADP bam-12413 230 16 the the DET bam-12413 230 17 non non ADJ bam-12413 230 18 - - ADJ bam-12413 230 19 surgical surgical ADJ bam-12413 230 20 management management NOUN bam-12413 230 21 of of ADP bam-12413 230 22 knee knee NOUN bam-12413 230 23 , , PUNCT bam-12413 230 24 hip hip NOUN bam-12413 230 25 , , PUNCT bam-12413 230 26 and and CCONJ bam-12413 230 27 polyarticular polyarticular VERB bam-12413 230 28 osteoarthritis osteoarthritis NOUN bam-12413 230 29 . . PUNCT bam-12413 231 1 osteoarthritis osteoarthritis NOUN bam-12413 231 2 cartilage cartilage NOUN bam-12413 231 3 2019;27:1578–89 2019;27:1578–89 NUM bam-12413 231 4 . . PUNCT bam-12413 232 1 36 36 NUM bam-12413 232 2 . . PUNCT bam-12413 233 1 aljehani aljehani PROPN bam-12413 233 2 ms ms PROPN bam-12413 233 3 , , PUNCT bam-12413 233 4 christensen christensen PROPN bam-12413 233 5 jc jc PROPN bam-12413 233 6 , , PUNCT bam-12413 233 7 snyder snyder NOUN bam-12413 233 8 - - PUNCT bam-12413 233 9 mackler mackler NOUN bam-12413 233 10 l l NOUN bam-12413 233 11 , , PUNCT bam-12413 233 12 et et PROPN bam-12413 233 13 al al PROPN bam-12413 233 14 . . PUNCT bam-12413 233 15 knee knee NOUN bam-12413 233 16 biomechanics biomechanic NOUN bam-12413 233 17 and and CCONJ bam-12413 233 18 contralateral contralateral ADJ bam-12413 233 19 knee knee NOUN bam-12413 233 20 osteoarthritis osteoarthritis NOUN bam-12413 233 21 progression progression NOUN bam-12413 233 22 after after ADP bam-12413 233 23 total total ADJ bam-12413 233 24 knee knee NOUN bam-12413 233 25 arthroplasty arthroplasty NOUN bam-12413 233 26 . . PUNCT bam-12413 234 1 gait gait ADJ bam-12413 234 2 posture posture NOUN bam-12413 234 3 2022;91:266–75 2022;91:266–75 NUM bam-12413 234 4 . . PUNCT bam-12413 234 5 37 37 NUM bam-12413 234 6 . . PUNCT bam-12413 235 1 sharma sharma PROPN bam-12413 235 2 l. l. PROPN bam-12413 235 3 osteoarthritis osteoarthritis PROPN bam-12413 235 4 of of ADP bam-12413 235 5 the the DET bam-12413 235 6 knee knee NOUN bam-12413 235 7 . . PUNCT bam-12413 236 1 solomon solomon PROPN bam-12413 236 2 cg cg PROPN bam-12413 236 3 , , PUNCT bam-12413 236 4 editor editor NOUN bam-12413 236 5 . . PUNCT bam-12413 237 1 n n PROPN bam-12413 237 2 engl engl PROPN bam-12413 237 3 j j PROPN bam-12413 237 4 med med PROPN bam-12413 237 5 2021;384:51–9 2021;384:51–9 NOUN bam-12413 237 6 . . PUNCT bam-12413 238 1 38 38 NUM bam-12413 238 2 . . PUNCT bam-12413 239 1 saviola saviola PROPN bam-12413 239 2 g g PROPN bam-12413 239 3 , , PUNCT bam-12413 239 4 da da NOUN bam-12413 239 5 campo campo NOUN bam-12413 239 6 g g PROPN bam-12413 239 7 , , PUNCT bam-12413 239 8 bianchini bianchini PROPN bam-12413 239 9 mc mc PROPN bam-12413 239 10 , , PUNCT bam-12413 239 11 et et PROPN bam-12413 239 12 al al PROPN bam-12413 239 13 . . PUNCT bam-12413 240 1 intra intra ADJ bam-12413 240 2 - - ADJ bam-12413 240 3 articular articular ADJ bam-12413 240 4 clodronate clodronate NOUN bam-12413 240 5 in in ADP bam-12413 240 6 patients patient NOUN bam-12413 240 7 with with ADP bam-12413 240 8 knee knee NOUN bam-12413 240 9 osteoarthritis osteoarthritis ADJ bam-12413 240 10 non non ADJ bam-12413 240 11 - - NOUN bam-12413 240 12 responder responder NOUN bam-12413 240 13 to to ADP bam-12413 240 14 intra intra ADJ bam-12413 240 15 - - ADJ bam-12413 240 16 articular articular ADJ bam-12413 240 17 hyaluronic hyaluronic ADJ bam-12413 240 18 acid acid NOUN bam-12413 240 19 a a DET bam-12413 240 20 case case NOUN bam-12413 240 21 report report NOUN bam-12413 240 22 series series NOUN bam-12413 240 23 of of ADP bam-12413 240 24 9 9 NUM bam-12413 240 25 patients patient NOUN bam-12413 240 26 with with ADP bam-12413 240 27 8 8 NUM bam-12413 240 28 - - PUNCT bam-12413 240 29 month month NOUN bam-12413 240 30 follow follow NOUN bam-12413 240 31 - - PUNCT bam-12413 240 32 up up NOUN bam-12413 240 33 . . PUNCT bam-12413 241 1 clin clin PROPN bam-12413 241 2 ter ter NOUN bam-12413 241 3 2023;174:245 2023;174:245 NUM bam-12413 241 4 - - SYM bam-12413 241 5 8 8 NUM bam-12413 241 6 . . NOUN bam-12413 241 7 39 39 NUM bam-12413 241 8 . . PUNCT bam-12413 242 1 international international ADJ bam-12413 242 2 classification classification NOUN bam-12413 242 3 of of ADP bam-12413 242 4 functioning function VERB bam-12413 242 5 , , PUNCT bam-12413 242 6 disability disability NOUN bam-12413 242 7 and and CCONJ bam-12413 242 8 health health NOUN bam-12413 242 9 . . PUNCT bam-12413 243 1 geneva geneva PROPN bam-12413 243 2 : : PUNCT bam-12413 243 3 world world PROPN bam-12413 243 4 health health NOUN bam-12413 243 5 organization organization NOUN bam-12413 243 6 ; ; PUNCT bam-12413 243 7 2001 2001 NUM bam-12413 243 8 . . PUNCT bam-12413 244 1 40 40 NUM bam-12413 244 2 . . PUNCT bam-12413 245 1 emans emans PROPN bam-12413 245 2 pj pj PROPN bam-12413 245 3 , , PUNCT bam-12413 245 4 skaliczki skaliczki VERB bam-12413 245 5 g g PROPN bam-12413 245 6 , , PUNCT bam-12413 245 7 haverkamp haverkamp PROPN bam-12413 245 8 d d PROPN bam-12413 245 9 , , PUNCT bam-12413 245 10 et et PROPN bam-12413 246 1 al al PROPN bam-12413 246 2 . . PUNCT bam-12413 246 3 kiomedine kiomedine PROPN bam-12413 246 4 ® ® NOUN bam-12413 246 5 cm cm NOUN bam-12413 246 6 - - PUNCT bam-12413 246 7 chitosan chitosan NOUN bam-12413 246 8 is be AUX bam-12413 246 9 effective effective ADJ bam-12413 246 10 for for ADP bam-12413 246 11 treating treat VERB bam-12413 246 12 advanced advanced ADJ bam-12413 246 13 symptomatic symptomatic ADJ bam-12413 246 14 knee knee NOUN bam-12413 246 15 osteoarthritis osteoarthritis NOUN bam-12413 246 16 up up ADP bam-12413 246 17 to to PART bam-12413 246 18 six six NUM bam-12413 246 19 months month NOUN bam-12413 246 20 following follow VERB bam-12413 246 21 a a DET bam-12413 246 22 single single ADJ bam-12413 246 23 intra intra ADJ bam-12413 246 24 - - ADJ bam-12413 246 25 articular articular ADJ bam-12413 246 26 injection injection NOUN bam-12413 246 27 : : PUNCT bam-12413 246 28 a a DET bam-12413 246 29 post post X bam-12413 246 30 hoc hoc X bam-12413 246 31 analysis analysis NOUN bam-12413 246 32 of of ADP bam-12413 246 33 aproove aproove NOUN bam-12413 246 34 clinical clinical ADJ bam-12413 246 35 study study NOUN bam-12413 246 36 . . PUNCT bam-12413 247 1 torj torj NOUN bam-12413 247 2 2023;17 2023;17 NUM bam-12413 247 3 : : PUNCT bam-12413 247 4 e187431292302010 e187431292302010 NOUN bam-12413 247 5 . . PUNCT bam-12413 248 1 disclaimer disclaimer PROPN bam-12413 248 2 all all DET bam-12413 248 3 claims claim NOUN bam-12413 248 4 expressed express VERB bam-12413 248 5 in in ADP bam-12413 248 6 this this DET bam-12413 248 7 article article NOUN bam-12413 248 8 are be AUX bam-12413 248 9 solely solely ADV bam-12413 248 10 those those PRON bam-12413 248 11 of of ADP bam-12413 248 12 the the DET bam-12413 248 13 authors author NOUN bam-12413 248 14 and and CCONJ bam-12413 248 15 do do AUX bam-12413 248 16 not not PART bam-12413 248 17 necessarily necessarily ADV bam-12413 248 18 represent represent VERB bam-12413 248 19 those those PRON bam-12413 248 20 of of ADP bam-12413 248 21 their their PRON bam-12413 248 22 affiliated affiliated ADJ bam-12413 248 23 organizations organization NOUN bam-12413 248 24 , , PUNCT bam-12413 248 25 or or CCONJ bam-12413 248 26 those those PRON bam-12413 248 27 of of ADP bam-12413 248 28 the the DET bam-12413 248 29 publisher publisher NOUN bam-12413 248 30 , , PUNCT bam-12413 248 31 the the DET bam-12413 248 32 editors editor NOUN bam-12413 248 33 and and CCONJ bam-12413 248 34 the the DET bam-12413 248 35 reviewers reviewer NOUN bam-12413 248 36 . . PUNCT bam-12413 249 1 any any DET bam-12413 249 2 product product NOUN bam-12413 249 3 that that PRON bam-12413 249 4 may may AUX bam-12413 249 5 be be AUX bam-12413 249 6 evaluated evaluate VERB bam-12413 249 7 in in ADP bam-12413 249 8 this this DET bam-12413 249 9 article article NOUN bam-12413 249 10 or or CCONJ bam-12413 249 11 claim claim NOUN bam-12413 249 12 that that PRON bam-12413 249 13 may may AUX bam-12413 249 14 be be AUX bam-12413 249 15 made make VERB bam-12413 249 16 by by ADP bam-12413 249 17 its its PRON bam-12413 249 18 manufacturer manufacturer NOUN bam-12413 249 19 is be AUX bam-12413 249 20 not not PART bam-12413 249 21 guaranteed guarantee VERB bam-12413 249 22 or or CCONJ bam-12413 249 23 endorsed endorse VERB bam-12413 249 24 by by ADP bam-12413 249 25 the the DET bam-12413 249 26 publisher publisher NOUN bam-12413 249 27 . . PUNCT bam-12413 250 1 submitted submit VERB bam-12413 250 2 : : PUNCT bam-12413 250 3 21 21 NUM bam-12413 250 4 february february NOUN bam-12413 250 5 2024 2024 NUM bam-12413 250 6 . . PUNCT bam-12413 251 1 accepted accept VERB bam-12413 251 2 : : PUNCT bam-12413 251 3 2 2 NUM bam-12413 251 4 may may PROPN bam-12413 251 5 2024 2024 NUM bam-12413 251 6 . . PUNCT bam-12413 252 1 early early ADJ bam-12413 252 2 access access NOUN bam-12413 252 3 : : PUNCT bam-12413 252 4 22 22 NUM bam-12413 252 5 august august PROPN bam-12413 252 6 2024 2024 NUM bam-12413 252 7 . . PUNCT bam-12413 253 1 38 38 NUM bam-12413 253 2 non non ADJ bam-12413 253 3 -co -co PROPN bam-12413 253 4 mmerc mmerc PROPN bam-12413 253 5 ial ial PROPN bam-12413 253 6 us us PROPN bam-12413 253 7 e e NOUN bam-12413 253 8 o o NOUN bam-12413 253 9 nly nly ADV