id	sid	tid	token	lemma	pos
bam-14214	1	1	1	1	NUM
bam-14214	1	2	european	european	ADJ
bam-14214	1	3	journal	journal	PROPN
bam-14214	1	4	of	of	ADP
bam-14214	1	5	translational	translational	ADJ
bam-14214	1	6	myology	myology	NOUN
bam-14214	1	7	7452	7452	NUM
bam-14214	1	8	-	-	SYM
bam-14214	1	9	pissn	pissn	NOUN
bam-14214	1	10	:	:	PUNCT
bam-14214	1	11	2037	2037	NUM
bam-14214	1	12	7460	7460	NUM
bam-14214	1	13	-	-	PUNCT
bam-14214	1	14	eissn	eissn	NOUN
bam-14214	1	15	:	:	PUNCT
bam-14214	1	16	2037	2037	NUM
bam-14214	1	17	https://www.pagepressjournals.org/index.php/bam/index	https://www.pagepressjournals.org/index.php/bam/index	NOUN
bam-14214	1	18	publisher	publisher	NOUN
bam-14214	1	19	's	's	PART
bam-14214	1	20	disclaimer	disclaimer	NOUN
bam-14214	1	21	.	.	PUNCT
bam-14214	2	1	e	e	X
bam-14214	2	2	-	-	NOUN
bam-14214	2	3	publishing	publishing	NOUN
bam-14214	2	4	ahead	ahead	ADV
bam-14214	2	5	of	of	ADP
bam-14214	2	6	print	print	NOUN
bam-14214	2	7	is	be	AUX
bam-14214	2	8	increasingly	increasingly	ADV
bam-14214	2	9	important	important	ADJ
bam-14214	2	10	for	for	ADP
bam-14214	2	11	the	the	DET
bam-14214	2	12	rapid	rapid	ADJ
bam-14214	2	13	dissemination	dissemination	NOUN
bam-14214	2	14	of	of	ADP
bam-14214	2	15	science	science	NOUN
bam-14214	2	16	.	.	PUNCT
bam-14214	3	1	the	the	DET
bam-14214	3	2	early	early	ADJ
bam-14214	3	3	access	access	NOUN
bam-14214	3	4	service	service	NOUN
bam-14214	3	5	lets	let	VERB
bam-14214	3	6	users	user	NOUN
bam-14214	3	7	access	access	VERB
bam-14214	3	8	peer	peer	NOUN
bam-14214	3	9	-	-	PUNCT
bam-14214	3	10	reviewed	review	VERB
bam-14214	3	11	articles	article	NOUN
bam-14214	3	12	well	well	ADV
bam-14214	3	13	before	before	ADP
bam-14214	3	14	print	print	NOUN
bam-14214	3	15	/	/	SYM
bam-14214	3	16	regular	regular	ADJ
bam-14214	3	17	issue	issue	NOUN
bam-14214	3	18	publication	publication	NOUN
bam-14214	3	19	,	,	PUNCT
bam-14214	3	20	significantly	significantly	ADV
bam-14214	3	21	reducing	reduce	VERB
bam-14214	3	22	the	the	DET
bam-14214	3	23	time	time	NOUN
bam-14214	3	24	it	it	PRON
bam-14214	3	25	takes	take	VERB
bam-14214	3	26	for	for	ADP
bam-14214	3	27	critical	critical	ADJ
bam-14214	3	28	findings	finding	NOUN
bam-14214	3	29	to	to	PART
bam-14214	3	30	reach	reach	VERB
bam-14214	3	31	the	the	DET
bam-14214	3	32	research	research	NOUN
bam-14214	3	33	community	community	NOUN
bam-14214	3	34	.	.	PUNCT
bam-14214	4	1	these	these	DET
bam-14214	4	2	articles	article	NOUN
bam-14214	4	3	are	be	AUX
bam-14214	4	4	searchable	searchable	ADJ
bam-14214	4	5	and	and	CCONJ
bam-14214	4	6	citable	citable	ADJ
bam-14214	4	7	by	by	ADP
bam-14214	4	8	their	their	PRON
bam-14214	4	9	doi	doi	NOUN
bam-14214	4	10	(	(	PUNCT
bam-14214	4	11	digital	digital	ADJ
bam-14214	4	12	object	object	NOUN
bam-14214	4	13	identifier	identifier	NOUN
bam-14214	4	14	)	)	PUNCT
bam-14214	4	15	.	.	PUNCT
bam-14214	5	1	the	the	DET
bam-14214	5	2	european	european	PROPN
bam-14214	5	3	journal	journal	PROPN
bam-14214	5	4	of	of	ADP
bam-14214	5	5	translational	translational	ADJ
bam-14214	5	6	myology	myology	NOUN
bam-14214	5	7	is	be	AUX
bam-14214	5	8	,	,	PUNCT
bam-14214	5	9	therefore	therefore	ADV
bam-14214	5	10	,	,	PUNCT
bam-14214	5	11	e	e	X
bam-14214	5	12	-	-	ADJ
bam-14214	5	13	publishing	publish	VERB
bam-14214	5	14	pdf	pdf	NOUN
bam-14214	5	15	files	file	NOUN
bam-14214	5	16	of	of	ADP
bam-14214	5	17	an	an	DET
bam-14214	5	18	early	early	ADJ
bam-14214	5	19	version	version	NOUN
bam-14214	5	20	of	of	ADP
bam-14214	5	21	manuscripts	manuscript	NOUN
bam-14214	5	22	that	that	PRON
bam-14214	5	23	undergone	undergo	VERB
bam-14214	5	24	a	a	DET
bam-14214	5	25	regular	regular	ADJ
bam-14214	5	26	peer	peer	NOUN
bam-14214	5	27	review	review	NOUN
bam-14214	5	28	and	and	CCONJ
bam-14214	5	29	have	have	AUX
bam-14214	5	30	been	be	AUX
bam-14214	5	31	accepted	accept	VERB
bam-14214	5	32	for	for	ADP
bam-14214	5	33	publication	publication	NOUN
bam-14214	5	34	,	,	PUNCT
bam-14214	5	35	but	but	CCONJ
bam-14214	5	36	have	have	AUX
bam-14214	5	37	not	not	PART
bam-14214	5	38	been	be	AUX
bam-14214	5	39	through	through	ADP
bam-14214	5	40	the	the	DET
bam-14214	5	41	typesetting	typesetting	NOUN
bam-14214	5	42	,	,	PUNCT
bam-14214	5	43	pagination	pagination	NOUN
bam-14214	5	44	and	and	CCONJ
bam-14214	5	45	proofreading	proofreading	NOUN
bam-14214	5	46	processes	process	NOUN
bam-14214	5	47	,	,	PUNCT
bam-14214	5	48	which	which	PRON
bam-14214	5	49	may	may	AUX
bam-14214	5	50	lead	lead	VERB
bam-14214	5	51	to	to	ADP
bam-14214	5	52	differences	difference	NOUN
bam-14214	5	53	between	between	ADP
bam-14214	5	54	this	this	DET
bam-14214	5	55	version	version	NOUN
bam-14214	5	56	and	and	CCONJ
bam-14214	5	57	the	the	DET
bam-14214	5	58	final	final	ADJ
bam-14214	5	59	one	one	NUM
bam-14214	5	60	.	.	PUNCT
bam-14214	6	1	the	the	DET
bam-14214	6	2	final	final	ADJ
bam-14214	6	3	version	version	NOUN
bam-14214	6	4	of	of	ADP
bam-14214	6	5	the	the	DET
bam-14214	6	6	manuscript	manuscript	NOUN
bam-14214	6	7	will	will	AUX
bam-14214	6	8	then	then	ADV
bam-14214	6	9	appear	appear	VERB
bam-14214	6	10	on	on	ADP
bam-14214	6	11	a	a	DET
bam-14214	6	12	regular	regular	ADJ
bam-14214	6	13	issue	issue	NOUN
bam-14214	6	14	of	of	ADP
bam-14214	6	15	the	the	DET
bam-14214	6	16	journal	journal	NOUN
bam-14214	6	17	.	.	PUNCT
bam-14214	7	1	e	e	X
bam-14214	7	2	-	-	NOUN
bam-14214	7	3	publishing	publishing	NOUN
bam-14214	7	4	of	of	ADP
bam-14214	7	5	this	this	DET
bam-14214	7	6	pdf	pdf	NOUN
bam-14214	7	7	file	file	NOUN
bam-14214	7	8	has	have	AUX
bam-14214	7	9	been	be	AUX
bam-14214	7	10	approved	approve	VERB
bam-14214	7	11	by	by	ADP
bam-14214	7	12	the	the	DET
bam-14214	7	13	authors	author	NOUN
bam-14214	7	14	.	.	PUNCT
bam-14214	8	1	eur	eur	PROPN
bam-14214	8	2	j	j	PROPN
bam-14214	8	3	transl	transl	PROPN
bam-14214	8	4	myol	myol	NOUN
bam-14214	8	5	2025	2025	NUM
bam-14214	8	6	[	[	X
bam-14214	8	7	online	online	ADV
bam-14214	8	8	ahead	ahead	ADV
bam-14214	8	9	of	of	ADP
bam-14214	8	10	print	print	NOUN
bam-14214	8	11	]	]	PUNCT
bam-14214	8	12	to	to	PART
bam-14214	8	13	cite	cite	VERB
bam-14214	8	14	this	this	DET
bam-14214	8	15	article	article	NOUN
bam-14214	8	16	:	:	PUNCT
bam-14214	8	17	aging	age	VERB
bam-14214	8	18	pathways	pathway	NOUN
bam-14214	8	19	and	and	CCONJ
bam-14214	8	20	enhance	enhance	VERB
bam-14214	8	21	survival	survival	NOUN
bam-14214	8	22	in	in	ADP
bam-14214	8	23	young	young	ADJ
bam-14214	8	24	mice	mouse	NOUN
bam-14214	8	25	:	:	PUNCT
bam-14214	8	26	a	a	DET
bam-14214	8	27	-irisin	-irisin	NOUN
bam-14214	8	28	and	and	CCONJ
bam-14214	8	29	exercise	exercise	NOUN
bam-14214	8	30	activate	activate	VERB
bam-14214	8	31	renal	renal	ADJ
bam-14214	8	32	anti	anti	NOUN
bam-14214	8	33	.	.	PROPN
bam-14214	8	34	s	s	PROPN
bam-14214	8	35	zamani	zamani	PROPN
bam-14214	8	36	,	,	PUNCT
bam-14214	8	37	h	h	NOUN
bam-14214	8	38	,	,	PUNCT
bam-14214	8	39	rezazadeh	rezazadeh	NOUN
bam-14214	8	40	,	,	PUNCT
bam-14214	8	41	m	m	PRON
bam-14214	8	42	,	,	PUNCT
bam-14214	8	43	homayounzs	homayounz	NOUN
bam-14214	8	44	aghili	aghili	VERB
bam-14214	8	45	14214.5.202ejtmdoi	14214.5.202ejtmdoi	NUM
bam-14214	8	46	:	:	PUNCT
bam-14214	8	47	10.4081	10.4081	NUM
bam-14214	8	48	/	/	SYM
bam-14214	8	49	myol	myol	NOUN
bam-14214	8	50	leur	leur	PROPN
bam-14214	8	51	j	j	PROPN
bam-14214	8	52	trans	trans	PROPN
bam-14214	8	53	.	.	PUNCT
bam-14214	9	1	kidney	kidney	PROPN
bam-14214	9	2	crosstalk	crosstalk	VERB
bam-14214	9	3	-	-	PUNCT
bam-14214	9	4	translational	translational	ADJ
bam-14214	9	5	insight	insight	NOUN
bam-14214	9	6	into	into	ADP
bam-14214	9	7	muscle	muscle	NOUN
bam-14214	9	8	©	©	PROPN
bam-14214	9	9	the	the	DET
bam-14214	9	10	author(s	author(s	PROPN
bam-14214	9	11	)	)	PUNCT
bam-14214	9	12	,	,	PUNCT
bam-14214	9	13	2025	2025	NUM
bam-14214	9	14	italy	italy	PROPN
bam-14214	9	15	,	,	PUNCT
bam-14214	9	16	pagepress	pagepress	NOUN
bam-14214	9	17	licensee	licensee	NOUN
bam-14214	9	18	.	.	PUNCT
bam-14214	10	1	any	any	DET
bam-14214	10	2	queries	query	NOUN
bam-14214	10	3	should	should	AUX
bam-14214	10	4	be	be	AUX
bam-14214	10	5	directed	direct	VERB
bam-14214	10	6	to	to	ADP
bam-14214	10	7	the	the	DET
bam-14214	10	8	corresponding	corresponding	ADJ
bam-14214	10	9	author	author	NOUN
bam-14214	10	10	for	for	ADP
bam-14214	10	11	the	the	DET
bam-14214	10	12	article.note	article.note	NOUN
bam-14214	10	13	:	:	PUNCT
bam-14214	10	14	the	the	DET
bam-14214	10	15	publisher	publisher	NOUN
bam-14214	10	16	is	be	AUX
bam-14214	10	17	not	not	PART
bam-14214	10	18	responsible	responsible	ADJ
bam-14214	10	19	for	for	ADP
bam-14214	10	20	the	the	DET
bam-14214	10	21	content	content	NOUN
bam-14214	10	22	or	or	CCONJ
bam-14214	10	23	functionality	functionality	NOUN
bam-14214	10	24	of	of	ADP
bam-14214	10	25	any	any	DET
bam-14214	10	26	supporting	support	VERB
bam-14214	10	27	information	information	NOUN
bam-14214	10	28	supplied	supply	VERB
bam-14214	10	29	by	by	ADP
bam-14214	10	30	the	the	DET
bam-14214	10	31	authors	author	NOUN
bam-14214	10	32	ed	ed	NOUN
bam-14214	10	33	organizations	organization	NOUN
bam-14214	10	34	,	,	PUNCT
bam-14214	10	35	or	or	CCONJ
bam-14214	10	36	those	those	PRON
bam-14214	10	37	of	of	ADP
bam-14214	10	38	the	the	DET
bam-14214	10	39	publisher	publisher	NOUN
bam-14214	10	40	,	,	PUNCT
bam-14214	10	41	the	the	DET
bam-14214	10	42	editors	editor	NOUN
bam-14214	10	43	and	and	CCONJ
bam-14214	10	44	the	the	DET
bam-14214	10	45	reviewers	reviewer	NOUN
bam-14214	10	46	.	.	PUNCT
bam-14214	11	1	any	any	DET
bam-14214	11	2	all	all	DET
bam-14214	11	3	claims	claim	NOUN
bam-14214	11	4	expressed	express	VERB
bam-14214	11	5	in	in	ADP
bam-14214	11	6	this	this	DET
bam-14214	11	7	article	article	NOUN
bam-14214	11	8	are	be	AUX
bam-14214	11	9	solely	solely	ADV
bam-14214	11	10	those	those	PRON
bam-14214	11	11	of	of	ADP
bam-14214	11	12	the	the	DET
bam-14214	11	13	authors	author	NOUN
bam-14214	11	14	and	and	CCONJ
bam-14214	11	15	do	do	AUX
bam-14214	11	16	not	not	PART
bam-14214	11	17	necessarily	necessarily	ADV
bam-14214	11	18	represent	represent	VERB
bam-14214	11	19	those	those	PRON
bam-14214	11	20	of	of	ADP
bam-14214	11	21	their	their	PRON
bam-14214	11	22	affiliat	affiliat	NOUN
bam-14214	11	23	the	the	DET
bam-14214	11	24	publisher.product	publisher.product	NOUN
bam-14214	11	25	that	that	PRON
bam-14214	11	26	may	may	AUX
bam-14214	11	27	be	be	AUX
bam-14214	11	28	evaluated	evaluate	VERB
bam-14214	11	29	in	in	ADP
bam-14214	11	30	this	this	DET
bam-14214	11	31	article	article	NOUN
bam-14214	11	32	or	or	CCONJ
bam-14214	11	33	claim	claim	NOUN
bam-14214	11	34	that	that	PRON
bam-14214	11	35	may	may	AUX
bam-14214	11	36	be	be	AUX
bam-14214	11	37	made	make	VERB
bam-14214	11	38	by	by	ADP
bam-14214	11	39	its	its	PRON
bam-14214	11	40	manufacturer	manufacturer	NOUN
bam-14214	11	41	is	be	AUX
bam-14214	11	42	not	not	PART
bam-14214	11	43	guaranteed	guarantee	VERB
bam-14214	11	44	or	or	CCONJ
bam-14214	11	45	endorsed	endorse	VERB
bam-14214	11	46	by	by	ADP
bam-14214	11	47	submi(ed	submi(ed	PROPN
bam-14214	11	48	:	:	PUNCT
bam-14214	11	49	2	2	NUM
bam-14214	11	50	august	august	PROPN
bam-14214	11	51	2025	2025	NUM
bam-14214	11	52	accepted	accept	VERB
bam-14214	11	53	:	:	PUNCT
bam-14214	11	54	8	8	NUM
bam-14214	11	55	october	october	NOUN
bam-14214	11	56	2025	2025	NUM
bam-14214	11	57	early	early	ADJ
bam-14214	11	58	access	access	NOUN
bam-14214	11	59	:	:	PUNCT
bam-14214	11	60	2	2	NUM
bam-14214	11	61	december	december	PROPN
bam-14214	11	62	2025	2025	NUM
bam-14214	11	63	https://www.pagepressjournals.org/index.php/bam/index	https://www.pagepressjournals.org/index.php/bam/index	NOUN
bam-14214	11	64	https://www.pagepress.org/site	https://www.pagepress.org/site	PROPN
bam-14214	11	65	2	2	NUM
bam-14214	11	66	irisin	irisin	NOUN
bam-14214	11	67	and	and	CCONJ
bam-14214	11	68	exercise	exercise	NOUN
bam-14214	11	69	activate	activate	VERB
bam-14214	11	70	renal	renal	ADJ
bam-14214	11	71	anti	anti	ADJ
bam-14214	11	72	-	-	ADJ
bam-14214	11	73	aging	aging	ADJ
bam-14214	11	74	pathways	pathway	NOUN
bam-14214	11	75	and	and	CCONJ
bam-14214	11	76	enhance	enhance	VERB
bam-14214	11	77	survival	survival	NOUN
bam-14214	11	78	in	in	ADP
bam-14214	11	79	young	young	ADJ
bam-14214	11	80	mice	mouse	NOUN
bam-14214	11	81	:	:	PUNCT
bam-14214	11	82	a	a	DET
bam-14214	11	83	translational	translational	ADJ
bam-14214	11	84	insight	insight	NOUN
bam-14214	11	85	into	into	ADP
bam-14214	11	86	muscle	muscle	NOUN
bam-14214	11	87	-	-	PUNCT
bam-14214	11	88	kidney	kidney	NOUN
bam-14214	11	89	crosstalk	crosstalk	NOUN
bam-14214	11	90	zahra	zahra	NOUN
bam-14214	11	91	sadat	sadat	PROPN
bam-14214	11	92	aghili,1,2	aghili,1,2	PROPN
bam-14214	11	93	mansour	mansour	PROPN
bam-14214	11	94	homayoun,3	homayoun,3	PROPN
bam-14214	11	95	hossein	hossein	PROPN
bam-14214	11	96	rezazadeh,4	rezazadeh,4	PROPN
bam-14214	11	97	saeed	saeed	PROPN
bam-14214	11	98	zamani3	zamani3	PROPN
bam-14214	12	1	1department	1department	NUM
bam-14214	12	2	of	of	ADP
bam-14214	12	3	parasitology	parasitology	NOUN
bam-14214	12	4	and	and	CCONJ
bam-14214	12	5	mycology	mycology	NOUN
bam-14214	12	6	,	,	PUNCT
bam-14214	12	7	school	school	NOUN
bam-14214	12	8	of	of	ADP
bam-14214	12	9	medicine	medicine	NOUN
bam-14214	12	10	,	,	PUNCT
bam-14214	12	11	isfahan	isfahan	PROPN
bam-14214	12	12	university	university	PROPN
bam-14214	12	13	of	of	ADP
bam-14214	12	14	medical	medical	ADJ
bam-14214	12	15	sciences	sciences	PROPN
bam-14214	12	16	,	,	PUNCT
bam-14214	12	17	isfahan	isfahan	NOUN
bam-14214	12	18	,	,	PUNCT
bam-14214	12	19	iran	iran	PROPN
bam-14214	12	20	;	;	PUNCT
bam-14214	13	1	2department	2department	NUM
bam-14214	13	2	of	of	ADP
bam-14214	13	3	molecular	molecular	ADJ
bam-14214	13	4	medicine	medicine	NOUN
bam-14214	13	5	,	,	PUNCT
bam-14214	13	6	school	school	NOUN
bam-14214	13	7	of	of	ADP
bam-14214	13	8	advanced	advanced	ADJ
bam-14214	13	9	technologies	technology	NOUN
bam-14214	13	10	,	,	PUNCT
bam-14214	13	11	shahrekord	shahrekord	PROPN
bam-14214	13	12	university	university	PROPN
bam-14214	13	13	of	of	ADP
bam-14214	13	14	medical	medical	ADJ
bam-14214	13	15	sciences	sciences	PROPN
bam-14214	13	16	,	,	PUNCT
bam-14214	13	17	shahrekord	shahrekord	NOUN
bam-14214	13	18	,	,	PUNCT
bam-14214	13	19	iran	iran	PROPN
bam-14214	13	20	;	;	PUNCT
bam-14214	13	21	3department	3department	NUM
bam-14214	13	22	of	of	ADP
bam-14214	13	23	anatomical	anatomical	ADJ
bam-14214	13	24	sciences	science	NOUN
bam-14214	13	25	,	,	PUNCT
bam-14214	13	26	school	school	NOUN
bam-14214	13	27	of	of	ADP
bam-14214	13	28	medicine	medicine	NOUN
bam-14214	13	29	,	,	PUNCT
bam-14214	13	30	isfahan	isfahan	PROPN
bam-14214	13	31	university	university	PROPN
bam-14214	13	32	of	of	ADP
bam-14214	13	33	medical	medical	ADJ
bam-14214	13	34	sciences	sciences	PROPN
bam-14214	13	35	,	,	PUNCT
bam-14214	13	36	isfahan	isfahan	NOUN
bam-14214	13	37	,	,	PUNCT
bam-14214	13	38	iran	iran	PROPN
bam-14214	13	39	;	;	PUNCT
bam-14214	13	40	4department	4department	NUM
bam-14214	13	41	of	of	ADP
bam-14214	13	42	physiology	physiology	NOUN
bam-14214	13	43	,	,	PUNCT
bam-14214	13	44	school	school	NOUN
bam-14214	13	45	of	of	ADP
bam-14214	13	46	medicine	medicine	NOUN
bam-14214	13	47	,	,	PUNCT
bam-14214	13	48	isfahan	isfahan	PROPN
bam-14214	13	49	university	university	PROPN
bam-14214	13	50	of	of	ADP
bam-14214	13	51	medical	medical	ADJ
bam-14214	13	52	sciences	sciences	PROPN
bam-14214	13	53	,	,	PUNCT
bam-14214	13	54	isfahan	isfahan	NOUN
bam-14214	13	55	,	,	PUNCT
bam-14214	13	56	iran	iran	PROPN
bam-14214	13	57	abstract	abstract	ADJ
bam-14214	13	58	irisin	irisin	PROPN
bam-14214	13	59	,	,	PUNCT
bam-14214	13	60	a	a	DET
bam-14214	13	61	myokine	myokine	NOUN
bam-14214	13	62	released	release	VERB
bam-14214	13	63	by	by	ADP
bam-14214	13	64	skeletal	skeletal	ADJ
bam-14214	13	65	muscle	muscle	NOUN
bam-14214	13	66	during	during	ADP
bam-14214	13	67	physical	physical	ADJ
bam-14214	13	68	activity	activity	NOUN
bam-14214	13	69	,	,	PUNCT
bam-14214	13	70	has	have	AUX
bam-14214	13	71	emerged	emerge	VERB
bam-14214	13	72	as	as	ADP
bam-14214	13	73	a	a	DET
bam-14214	13	74	key	key	ADJ
bam-14214	13	75	regulator	regulator	NOUN
bam-14214	13	76	of	of	ADP
bam-14214	13	77	energy	energy	NOUN
bam-14214	13	78	metabolism	metabolism	NOUN
bam-14214	13	79	,	,	PUNCT
bam-14214	13	80	cellular	cellular	ADJ
bam-14214	13	81	stress	stress	NOUN
bam-14214	13	82	responses	response	NOUN
bam-14214	13	83	,	,	PUNCT
bam-14214	13	84	and	and	CCONJ
bam-14214	13	85	longevity	longevity	NOUN
bam-14214	13	86	pathways	pathway	NOUN
bam-14214	13	87	.	.	PUNCT
bam-14214	14	1	while	while	SCONJ
bam-14214	14	2	previous	previous	ADJ
bam-14214	14	3	studies	study	NOUN
bam-14214	14	4	have	have	AUX
bam-14214	14	5	focused	focus	VERB
bam-14214	14	6	on	on	ADP
bam-14214	14	7	aged	aged	ADJ
bam-14214	14	8	animal	animal	NOUN
bam-14214	14	9	-	-	PUNCT
bam-14214	14	10	models	model	NOUN
bam-14214	14	11	or	or	CCONJ
bam-14214	14	12	pathological	pathological	ADJ
bam-14214	14	13	states	state	NOUN
bam-14214	14	14	,	,	PUNCT
bam-14214	14	15	the	the	DET
bam-14214	14	16	long	long	ADJ
bam-14214	14	17	-	-	PUNCT
bam-14214	14	18	term	term	NOUN
bam-14214	14	19	impact	impact	NOUN
bam-14214	14	20	of	of	ADP
bam-14214	14	21	earlylife	earlylife	NOUN
bam-14214	14	22	interventions	intervention	NOUN
bam-14214	14	23	on	on	ADP
bam-14214	14	24	molecular	molecular	ADJ
bam-14214	14	25	aging	age	VERB
bam-14214	14	26	pathways	pathway	NOUN
bam-14214	14	27	remains	remains	AUX
bam-14214	14	28	poorly	poorly	ADV
bam-14214	14	29	understood	understand	VERB
bam-14214	14	30	.	.	PUNCT
bam-14214	15	1	this	this	DET
bam-14214	15	2	study	study	NOUN
bam-14214	15	3	investigated	investigate	VERB
bam-14214	15	4	whether	whether	SCONJ
bam-14214	15	5	early	early	ADJ
bam-14214	15	6	-	-	PUNCT
bam-14214	15	7	life	life	NOUN
bam-14214	15	8	irisin	irisin	NOUN
bam-14214	15	9	administration	administration	NOUN
bam-14214	15	10	and	and	CCONJ
bam-14214	15	11	physical	physical	ADJ
bam-14214	15	12	exercise	exercise	NOUN
bam-14214	15	13	could	could	AUX
bam-14214	15	14	modulate	modulate	VERB
bam-14214	15	15	the	the	DET
bam-14214	15	16	renal	renal	ADJ
bam-14214	15	17	-	-	PUNCT
bam-14214	15	18	expression	expression	NOUN
bam-14214	15	19	of	of	ADP
bam-14214	15	20	klotho	klotho	PROPN
bam-14214	15	21	and	and	CCONJ
bam-14214	15	22	hsp70	hsp70	NOUN
bam-14214	15	23	—	—	PUNCT
bam-14214	15	24	two	two	NUM
bam-14214	15	25	hallmark	hallmark	ADJ
bam-14214	15	26	genes	gene	NOUN
bam-14214	15	27	of	of	ADP
bam-14214	15	28	cellular	cellular	ADJ
bam-14214	15	29	protection	protection	NOUN
bam-14214	15	30	and	and	CCONJ
bam-14214	15	31	anti	anti	ADJ
bam-14214	15	32	-	-	ADJ
bam-14214	15	33	aging	age	VERB
bam-14214	15	34	in	in	ADP
bam-14214	15	35	young	young	ADJ
bam-14214	15	36	adult	adult	NOUN
bam-14214	15	37	nmri	nmri	ADJ
bam-14214	15	38	mice	mouse	NOUN
bam-14214	15	39	.	.	PUNCT
bam-14214	16	1	animals	animal	NOUN
bam-14214	16	2	underwent	undergo	VERB
bam-14214	16	3	8	8	NUM
bam-14214	16	4	weeks	week	NOUN
bam-14214	16	5	of	of	ADP
bam-14214	16	6	resistance	resistance	NOUN
bam-14214	16	7	training	training	NOUN
bam-14214	16	8	,	,	PUNCT
bam-14214	16	9	endurance	endurance	NOUN
bam-14214	16	10	training	training	NOUN
bam-14214	16	11	,	,	PUNCT
bam-14214	16	12	or	or	CCONJ
bam-14214	16	13	irisin	irisin	VERB
bam-14214	16	14	injection	injection	NOUN
bam-14214	16	15	.	.	PUNCT
bam-14214	17	1	plasma	plasma	NOUN
bam-14214	17	2	irisin	irisin	NOUN
bam-14214	17	3	was	be	AUX
bam-14214	17	4	quantified	quantify	VERB
bam-14214	17	5	via	via	ADP
bam-14214	17	6	elisa	elisa	NOUN
bam-14214	17	7	,	,	PUNCT
bam-14214	17	8	and	and	CCONJ
bam-14214	17	9	renal	renal	ADJ
bam-14214	17	10	klotho	klotho	PROPN
bam-14214	17	11	and	and	CCONJ
bam-14214	17	12	hsp70	hsp70	NOUN
bam-14214	17	13	expression	expression	NOUN
bam-14214	17	14	levels	level	NOUN
bam-14214	17	15	were	be	AUX
bam-14214	17	16	assessed	assess	VERB
bam-14214	17	17	using	use	VERB
bam-14214	17	18	qpcr	qpcr	ADJ
bam-14214	17	19	and	and	CCONJ
bam-14214	17	20	western	western	ADJ
bam-14214	17	21	-	-	PUNCT
bam-14214	17	22	blotting	blot	VERB
bam-14214	17	23	.	.	PUNCT
bam-14214	18	1	all	all	DET
bam-14214	18	2	interventions	intervention	NOUN
bam-14214	18	3	significantly	significantly	ADV
bam-14214	18	4	increased	increase	VERB
bam-14214	18	5	circulating	circulate	VERB
bam-14214	18	6	irisin	irisin	NOUN
bam-14214	18	7	and	and	CCONJ
bam-14214	18	8	upregulated	upregulate	VERB
bam-14214	18	9	klotho	klotho	NOUN
bam-14214	18	10	and	and	CCONJ
bam-14214	18	11	hsp70	hsp70	NOUN
bam-14214	18	12	at	at	ADP
bam-14214	18	13	both	both	CCONJ
bam-14214	18	14	transcriptional	transcriptional	ADJ
bam-14214	18	15	and	and	CCONJ
bam-14214	18	16	protein	protein	NOUN
bam-14214	18	17	levels	level	NOUN
bam-14214	18	18	,	,	PUNCT
bam-14214	18	19	with	with	ADP
bam-14214	18	20	resistance	resistance	NOUN
bam-14214	18	21	training	training	NOUN
bam-14214	18	22	inducing	induce	VERB
bam-14214	18	23	the	the	DET
bam-14214	18	24	most	most	ADV
bam-14214	18	25	pronounced	pronounce	VERB
bam-14214	18	26	effects	effect	NOUN
bam-14214	18	27	.	.	PUNCT
bam-14214	19	1	a	a	DET
bam-14214	19	2	20	20	NUM
bam-14214	19	3	-	-	PUNCT
bam-14214	19	4	month	month	NOUN
bam-14214	19	5	survival	survival	NOUN
bam-14214	19	6	analysis	analysis	NOUN
bam-14214	19	7	showed	show	VERB
bam-14214	19	8	a	a	DET
bam-14214	19	9	trend	trend	NOUN
bam-14214	19	10	toward	toward	ADP
bam-14214	19	11	improved	improved	ADJ
bam-14214	19	12	longevity	longevity	NOUN
bam-14214	19	13	in	in	ADP
bam-14214	19	14	all	all	DET
bam-14214	19	15	intervention	intervention	NOUN
bam-14214	19	16	groups	group	NOUN
bam-14214	19	17	.	.	PUNCT
bam-14214	20	1	these	these	DET
bam-14214	20	2	findings	finding	NOUN
bam-14214	20	3	suggest	suggest	VERB
bam-14214	20	4	that	that	SCONJ
bam-14214	20	5	early	early	ADJ
bam-14214	20	6	-	-	PUNCT
bam-14214	20	7	life	life	NOUN
bam-14214	20	8	exercise	exercise	NOUN
bam-14214	20	9	and	and	CCONJ
bam-14214	20	10	irisin	irisin	NOUN
bam-14214	20	11	exposure	exposure	NOUN
bam-14214	20	12	may	may	AUX
bam-14214	20	13	activate	activate	VERB
bam-14214	20	14	renoprotective	renoprotective	ADJ
bam-14214	20	15	and	and	CCONJ
bam-14214	20	16	longevity	longevity	NOUN
bam-14214	20	17	-	-	PUNCT
bam-14214	20	18	associated	associate	VERB
bam-14214	20	19	pathways	pathway	NOUN
bam-14214	20	20	before	before	ADP
bam-14214	20	21	the	the	DET
bam-14214	20	22	onset	onset	NOUN
bam-14214	20	23	of	of	ADP
bam-14214	20	24	molecular	molecular	ADJ
bam-14214	20	25	aging	aging	NOUN
bam-14214	20	26	,	,	PUNCT
bam-14214	20	27	supporting	support	VERB
bam-14214	20	28	their	their	PRON
bam-14214	20	29	potential	potential	NOUN
bam-14214	20	30	as	as	ADP
bam-14214	20	31	preventive	preventive	ADJ
bam-14214	20	32	strategies	strategy	NOUN
bam-14214	20	33	in	in	ADP
bam-14214	20	34	translational	translational	ADJ
bam-14214	20	35	geroscience	geroscience	NOUN
bam-14214	20	36	.	.	PUNCT
bam-14214	21	1	key	key	ADJ
bam-14214	21	2	words	word	NOUN
bam-14214	21	3	:	:	PUNCT
bam-14214	21	4	aging	aging	NOUN
bam-14214	21	5	,	,	PUNCT
bam-14214	21	6	exercise	exercise	NOUN
bam-14214	21	7	,	,	PUNCT
bam-14214	21	8	irisin	irisin	NOUN
bam-14214	21	9	,	,	PUNCT
bam-14214	21	10	klotho	klotho	PROPN
bam-14214	21	11	,	,	PUNCT
bam-14214	21	12	hsp70	hsp70	NOUN
bam-14214	21	13	,	,	PUNCT
bam-14214	21	14	preventive	preventive	ADJ
bam-14214	21	15	intervention	intervention	NOUN
bam-14214	21	16	,	,	PUNCT
bam-14214	21	17	renal	renal	ADJ
bam-14214	21	18	gene	gene	NOUN
bam-14214	21	19	expression	expression	NOUN
bam-14214	21	20	.	.	PUNCT
bam-14214	22	1	3	3	NUM
bam-14214	22	2	introduction	introduction	NOUN
bam-14214	22	3	aging	aging	NOUN
bam-14214	22	4	is	be	AUX
bam-14214	22	5	a	a	DET
bam-14214	22	6	progressive	progressive	ADJ
bam-14214	22	7	and	and	CCONJ
bam-14214	22	8	multifactorial	multifactorial	ADJ
bam-14214	22	9	process	process	NOUN
bam-14214	22	10	characterized	characterize	VERB
bam-14214	22	11	by	by	ADP
bam-14214	22	12	the	the	DET
bam-14214	22	13	gradual	gradual	ADJ
bam-14214	22	14	deterioration	deterioration	NOUN
bam-14214	22	15	of	of	ADP
bam-14214	22	16	physiological	physiological	ADJ
bam-14214	22	17	systems	system	NOUN
bam-14214	22	18	,	,	PUNCT
bam-14214	22	19	with	with	ADP
bam-14214	22	20	the	the	DET
bam-14214	22	21	kidney	kidney	NOUN
bam-14214	22	22	being	be	AUX
bam-14214	22	23	particularly	particularly	ADV
bam-14214	22	24	vulnerable	vulnerable	ADJ
bam-14214	22	25	due	due	ADP
bam-14214	22	26	to	to	ADP
bam-14214	22	27	its	its	PRON
bam-14214	22	28	high	high	ADJ
bam-14214	22	29	metabolic	metabolic	NOUN
bam-14214	22	30	demand	demand	NOUN
bam-14214	22	31	and	and	CCONJ
bam-14214	22	32	pivotal	pivotal	ADJ
bam-14214	22	33	role	role	NOUN
bam-14214	22	34	in	in	ADP
bam-14214	22	35	systemic	systemic	ADJ
bam-14214	22	36	homeostasis.1	homeostasis.1	PROPN
bam-14214	22	37	-	-	PUNCT
bam-14214	22	38	3	3	NUM
bam-14214	22	39	central	central	NOUN
bam-14214	22	40	to	to	ADP
bam-14214	22	41	renal	renal	ADJ
bam-14214	22	42	aging	aging	NOUN
bam-14214	22	43	is	be	AUX
bam-14214	22	44	the	the	DET
bam-14214	22	45	decline	decline	NOUN
bam-14214	22	46	of	of	ADP
bam-14214	22	47	klotho	klotho	NOUN
bam-14214	22	48	,	,	PUNCT
bam-14214	22	49	a	a	DET
bam-14214	22	50	transmembrane	transmembrane	NOUN
bam-14214	22	51	and	and	CCONJ
bam-14214	22	52	soluble	soluble	ADJ
bam-14214	22	53	protein	protein	NOUN
bam-14214	22	54	predominantly	predominantly	ADV
bam-14214	22	55	expressed	express	VERB
bam-14214	22	56	in	in	ADP
bam-14214	22	57	the	the	DET
bam-14214	22	58	kidney	kidney	NOUN
bam-14214	22	59	,	,	PUNCT
bam-14214	22	60	known	know	VERB
bam-14214	22	61	for	for	ADP
bam-14214	22	62	its	its	PRON
bam-14214	22	63	antiinflammatory	antiinflammatory	NOUN
bam-14214	22	64	,	,	PUNCT
bam-14214	22	65	antioxidative	antioxidative	ADJ
bam-14214	22	66	,	,	PUNCT
bam-14214	22	67	and	and	CCONJ
bam-14214	22	68	metabolic	metabolic	NOUN
bam-14214	22	69	regulatory	regulatory	ADJ
bam-14214	22	70	functions.4,5	functions.4,5	NOUN
bam-14214	22	71	diminished	diminish	VERB
bam-14214	22	72	klotho	klotho	PROPN
bam-14214	22	73	levels	level	NOUN
bam-14214	22	74	have	have	AUX
bam-14214	22	75	been	be	AUX
bam-14214	22	76	linked	link	VERB
bam-14214	22	77	to	to	PART
bam-14214	22	78	accelerated	accelerate	VERB
bam-14214	22	79	aging	age	VERB
bam-14214	22	80	phenotypes	phenotype	NOUN
bam-14214	22	81	and	and	CCONJ
bam-14214	22	82	increased	increase	VERB
bam-14214	22	83	risk	risk	NOUN
bam-14214	22	84	of	of	ADP
bam-14214	22	85	chronic	chronic	ADJ
bam-14214	22	86	kidney	kidney	NOUN
bam-14214	22	87	disease	disease	NOUN
bam-14214	22	88	and	and	CCONJ
bam-14214	22	89	other	other	ADJ
bam-14214	22	90	age	age	NOUN
bam-14214	22	91	-	-	PUNCT
bam-14214	22	92	related	relate	VERB
bam-14214	22	93	disorders.6	disorders.6	PROPN
bam-14214	22	94	physical	physical	ADJ
bam-14214	22	95	activity	activity	NOUN
bam-14214	22	96	has	have	AUX
bam-14214	22	97	emerged	emerge	VERB
bam-14214	22	98	as	as	ADP
bam-14214	22	99	a	a	DET
bam-14214	22	100	non	non	ADJ
bam-14214	22	101	-	-	ADJ
bam-14214	22	102	pharmacological	pharmacological	ADJ
bam-14214	22	103	intervention	intervention	NOUN
bam-14214	22	104	capable	capable	ADJ
bam-14214	22	105	of	of	ADP
bam-14214	22	106	enhancing	enhance	VERB
bam-14214	22	107	klotho	klotho	ADJ
bam-14214	22	108	expression	expression	NOUN
bam-14214	22	109	,	,	PUNCT
bam-14214	22	110	possibly	possibly	ADV
bam-14214	22	111	via	via	ADP
bam-14214	22	112	muscle	muscle	NOUN
bam-14214	22	113	-	-	PUNCT
bam-14214	22	114	kidney	kidney	NOUN
bam-14214	22	115	crosstalk	crosstalk	NOUN
bam-14214	22	116	mediated	mediate	VERB
bam-14214	22	117	by	by	ADP
bam-14214	22	118	exercise	exercise	NOUN
bam-14214	22	119	-	-	PUNCT
bam-14214	22	120	induced	induce	VERB
bam-14214	22	121	myokines.7,8	myokines.7,8	NOUN
bam-14214	22	122	among	among	ADP
bam-14214	22	123	these	these	PRON
bam-14214	22	124	,	,	PUNCT
bam-14214	22	125	irisin	irisin	NOUN
bam-14214	22	126	—	—	PUNCT
bam-14214	22	127	secreted	secrete	VERB
bam-14214	22	128	by	by	ADP
bam-14214	22	129	skeletal	skeletal	ADJ
bam-14214	22	130	muscle	muscle	NOUN
bam-14214	22	131	during	during	ADP
bam-14214	22	132	physical	physical	ADJ
bam-14214	22	133	exertion	exertion	NOUN
bam-14214	22	134	—	—	PUNCT
bam-14214	22	135	has	have	AUX
bam-14214	22	136	shown	show	VERB
bam-14214	22	137	promise	promise	NOUN
bam-14214	22	138	in	in	ADP
bam-14214	22	139	modulating	modulate	VERB
bam-14214	22	140	metabolic	metabolic	NOUN
bam-14214	22	141	and	and	CCONJ
bam-14214	22	142	stress	stress	NOUN
bam-14214	22	143	-	-	PUNCT
bam-14214	22	144	response	response	NOUN
bam-14214	22	145	pathways	pathway	NOUN
bam-14214	22	146	,	,	PUNCT
bam-14214	22	147	suggesting	suggest	VERB
bam-14214	22	148	it	it	PRON
bam-14214	22	149	may	may	AUX
bam-14214	22	150	act	act	VERB
bam-14214	22	151	as	as	ADP
bam-14214	22	152	an	an	DET
bam-14214	22	153	exercise	exercise	NOUN
bam-14214	22	154	mimetic.9,10	mimetic.9,10	NOUN
bam-14214	22	155	another	another	DET
bam-14214	22	156	relevant	relevant	ADJ
bam-14214	22	157	molecular	molecular	ADJ
bam-14214	22	158	target	target	NOUN
bam-14214	22	159	is	be	AUX
bam-14214	22	160	heat	heat	NOUN
bam-14214	22	161	shock	shock	NOUN
bam-14214	22	162	protein	protein	NOUN
bam-14214	22	163	70	70	NUM
bam-14214	22	164	(	(	PUNCT
bam-14214	22	165	hsp70	hsp70	NOUN
bam-14214	22	166	)	)	PUNCT
bam-14214	22	167	,	,	PUNCT
bam-14214	22	168	a	a	DET
bam-14214	22	169	chaperone	chaperone	NOUN
bam-14214	22	170	protein	protein	NOUN
bam-14214	22	171	involved	involve	VERB
bam-14214	22	172	in	in	ADP
bam-14214	22	173	proteostasis	proteostasis	NOUN
bam-14214	22	174	and	and	CCONJ
bam-14214	22	175	cellular	cellular	ADJ
bam-14214	22	176	resilience	resilience	NOUN
bam-14214	22	177	,	,	PUNCT
bam-14214	22	178	which	which	PRON
bam-14214	22	179	,	,	PUNCT
bam-14214	22	180	like	like	ADP
bam-14214	22	181	klotho	klotho	NOUN
bam-14214	22	182	,	,	PUNCT
bam-14214	22	183	declines	decline	VERB
bam-14214	22	184	with	with	ADP
bam-14214	22	185	age	age	NOUN
bam-14214	22	186	and	and	CCONJ
bam-14214	22	187	contributes	contribute	VERB
bam-14214	22	188	to	to	ADP
bam-14214	22	189	cellular	cellular	ADJ
bam-14214	22	190	vulnerability.3,11,12	vulnerability.3,11,12	NOUN
bam-14214	22	191	its	its	PRON
bam-14214	22	192	potential	potential	ADJ
bam-14214	22	193	interplay	interplay	NOUN
bam-14214	22	194	with	with	ADP
bam-14214	22	195	klotho	klotho	PROPN
bam-14214	22	196	in	in	ADP
bam-14214	22	197	renal	renal	ADJ
bam-14214	22	198	tissue	tissue	NOUN
bam-14214	22	199	remains	remain	VERB
bam-14214	22	200	an	an	DET
bam-14214	22	201	area	area	NOUN
bam-14214	22	202	of	of	ADP
bam-14214	22	203	active	active	ADJ
bam-14214	22	204	exploration	exploration	NOUN
bam-14214	22	205	.	.	PUNCT
bam-14214	23	1	although	although	SCONJ
bam-14214	23	2	many	many	ADJ
bam-14214	23	3	studies	study	NOUN
bam-14214	23	4	have	have	AUX
bam-14214	23	5	investigated	investigate	VERB
bam-14214	23	6	these	these	DET
bam-14214	23	7	molecules	molecule	NOUN
bam-14214	23	8	in	in	ADP
bam-14214	23	9	aged	aged	ADJ
bam-14214	23	10	or	or	CCONJ
bam-14214	23	11	disease	disease	NOUN
bam-14214	23	12	-	-	PUNCT
bam-14214	23	13	prone	prone	ADJ
bam-14214	23	14	models	model	NOUN
bam-14214	23	15	,	,	PUNCT
bam-14214	23	16	less	less	ADV
bam-14214	23	17	is	be	AUX
bam-14214	23	18	known	know	VERB
bam-14214	23	19	about	about	ADP
bam-14214	23	20	how	how	SCONJ
bam-14214	23	21	early	early	ADJ
bam-14214	23	22	-	-	PUNCT
bam-14214	23	23	life	life	NOUN
bam-14214	23	24	interventions	intervention	NOUN
bam-14214	23	25	such	such	ADJ
bam-14214	23	26	as	as	ADP
bam-14214	23	27	physical	physical	ADJ
bam-14214	23	28	training	training	NOUN
bam-14214	23	29	or	or	CCONJ
bam-14214	23	30	irisin	irisin	NOUN
bam-14214	23	31	administration	administration	NOUN
bam-14214	23	32	might	might	AUX
bam-14214	23	33	preemptively	preemptively	ADV
bam-14214	23	34	activate	activate	VERB
bam-14214	23	35	protective	protective	ADJ
bam-14214	23	36	molecular	molecular	ADJ
bam-14214	23	37	pathways	pathway	NOUN
bam-14214	23	38	before	before	ADP
bam-14214	23	39	the	the	DET
bam-14214	23	40	onset	onset	NOUN
bam-14214	23	41	of	of	ADP
bam-14214	23	42	age	age	NOUN
bam-14214	23	43	-	-	PUNCT
bam-14214	23	44	related	relate	VERB
bam-14214	23	45	dysfunction	dysfunction	NOUN
bam-14214	23	46	.	.	PUNCT
bam-14214	24	1	understanding	understand	VERB
bam-14214	24	2	such	such	ADJ
bam-14214	24	3	early	early	ADJ
bam-14214	24	4	modulation	modulation	NOUN
bam-14214	24	5	is	be	AUX
bam-14214	24	6	crucial	crucial	ADJ
bam-14214	24	7	for	for	ADP
bam-14214	24	8	the	the	DET
bam-14214	24	9	development	development	NOUN
bam-14214	24	10	of	of	ADP
bam-14214	24	11	preventive	preventive	ADJ
bam-14214	24	12	strategies	strategy	NOUN
bam-14214	24	13	aimed	aim	VERB
bam-14214	24	14	at	at	ADP
bam-14214	24	15	extending	extend	VERB
bam-14214	24	16	healthspan	healthspan	NOUN
bam-14214	24	17	rather	rather	ADV
bam-14214	24	18	than	than	ADP
bam-14214	24	19	merely	merely	ADV
bam-14214	24	20	treating	treat	VERB
bam-14214	24	21	disease	disease	NOUN
bam-14214	24	22	.	.	PUNCT
bam-14214	25	1	in	in	ADP
bam-14214	25	2	this	this	DET
bam-14214	25	3	study	study	NOUN
bam-14214	25	4	,	,	PUNCT
bam-14214	25	5	we	we	PRON
bam-14214	25	6	examined	examine	VERB
bam-14214	25	7	the	the	DET
bam-14214	25	8	effects	effect	NOUN
bam-14214	25	9	of	of	ADP
bam-14214	25	10	two	two	NUM
bam-14214	25	11	exercise	exercise	NOUN
bam-14214	25	12	modalities	modality	NOUN
bam-14214	25	13	—	—	PUNCT
bam-14214	25	14	resistance	resistance	NOUN
bam-14214	25	15	and	and	CCONJ
bam-14214	25	16	endurance	endurance	NOUN
bam-14214	25	17	training	training	NOUN
bam-14214	25	18	—	—	PUNCT
bam-14214	25	19	alongside	alongside	ADP
bam-14214	25	20	exogenous	exogenous	ADJ
bam-14214	25	21	irisin	irisin	PROPN
bam-14214	25	22	administration	administration	NOUN
bam-14214	25	23	on	on	ADP
bam-14214	25	24	the	the	DET
bam-14214	25	25	renal	renal	ADJ
bam-14214	25	26	expression	expression	NOUN
bam-14214	25	27	of	of	ADP
bam-14214	25	28	klotho	klotho	PROPN
bam-14214	25	29	and	and	CCONJ
bam-14214	25	30	hsp70	hsp70	NOUN
bam-14214	25	31	in	in	ADP
bam-14214	25	32	young	young	ADJ
bam-14214	25	33	adult	adult	NOUN
bam-14214	25	34	nmri	nmri	ADJ
bam-14214	25	35	mice	mouse	NOUN
bam-14214	25	36	.	.	PUNCT
bam-14214	26	1	by	by	ADP
bam-14214	26	2	evaluating	evaluate	VERB
bam-14214	26	3	molecular	molecular	ADJ
bam-14214	26	4	and	and	CCONJ
bam-14214	26	5	survival	survival	NOUN
bam-14214	26	6	outcomes	outcome	NOUN
bam-14214	26	7	,	,	PUNCT
bam-14214	26	8	we	we	PRON
bam-14214	26	9	aimed	aim	VERB
bam-14214	26	10	to	to	PART
bam-14214	26	11	explore	explore	VERB
bam-14214	26	12	the	the	DET
bam-14214	26	13	potential	potential	NOUN
bam-14214	26	14	of	of	ADP
bam-14214	26	15	these	these	DET
bam-14214	26	16	interventions	intervention	NOUN
bam-14214	26	17	to	to	PART
bam-14214	26	18	enhance	enhance	VERB
bam-14214	26	19	renoprotective	renoprotective	ADJ
bam-14214	26	20	and	and	CCONJ
bam-14214	26	21	anti	anti	ADJ
bam-14214	26	22	-	-	ADJ
bam-14214	26	23	aging	aging	ADJ
bam-14214	26	24	mechanisms	mechanism	NOUN
bam-14214	26	25	during	during	ADP
bam-14214	26	26	early	early	ADJ
bam-14214	26	27	adulthood	adulthood	NOUN
bam-14214	26	28	,	,	PUNCT
bam-14214	26	29	thereby	thereby	ADV
bam-14214	26	30	offering	offer	VERB
bam-14214	26	31	insight	insight	NOUN
bam-14214	26	32	into	into	ADP
bam-14214	26	33	novel	novel	ADJ
bam-14214	26	34	strategies	strategy	NOUN
bam-14214	26	35	for	for	ADP
bam-14214	26	36	delaying	delay	VERB
bam-14214	26	37	systemic	systemic	ADJ
bam-14214	26	38	aging	aging	NOUN
bam-14214	26	39	.	.	PUNCT
bam-14214	27	1	materials	material	NOUN
bam-14214	27	2	and	and	CCONJ
bam-14214	27	3	methods	method	NOUN
bam-14214	27	4	materials	material	NOUN
bam-14214	27	5	recombinant	recombinant	ADJ
bam-14214	27	6	irisin	irisin	NOUN
bam-14214	27	7	(	(	PUNCT
bam-14214	27	8	cat	cat	NOUN
bam-14214	27	9	.	.	PUNCT
bam-14214	28	1	no	no	INTJ
bam-14214	28	2	.	.	NOUN
bam-14214	28	3	067	067	NUM
bam-14214	28	4	-	-	SYM
bam-14214	28	5	29	29	NUM
bam-14214	28	6	)	)	PUNCT
bam-14214	28	7	was	be	AUX
bam-14214	28	8	purchased	purchase	VERB
bam-14214	28	9	from	from	ADP
bam-14214	28	10	phoenix	phoenix	PROPN
bam-14214	28	11	pharmaceuticals	pharmaceuticals	PROPN
bam-14214	28	12	(	(	PUNCT
bam-14214	28	13	ca	ca	NOUN
bam-14214	28	14	,	,	PUNCT
bam-14214	28	15	usa	usa	PROPN
bam-14214	28	16	)	)	PUNCT
bam-14214	28	17	.	.	PUNCT
bam-14214	29	1	trizol	trizol	PROPN
bam-14214	29	2	reagent	reagent	NOUN
bam-14214	29	3	,	,	PUNCT
bam-14214	29	4	cdna	cdna	PROPN
bam-14214	29	5	synthesis	synthesis	NOUN
bam-14214	29	6	kits	kit	NOUN
bam-14214	29	7	,	,	PUNCT
bam-14214	29	8	and	and	CCONJ
bam-14214	29	9	bca	bca	PROPN
bam-14214	29	10	assay	assay	NOUN
bam-14214	29	11	reagents	reagent	NOUN
bam-14214	29	12	were	be	AUX
bam-14214	29	13	from	from	ADP
bam-14214	29	14	thermo	thermo	PROPN
bam-14214	29	15	fisher	fisher	PROPN
bam-14214	29	16	scientific	scientific	PROPN
bam-14214	29	17	.	.	PUNCT
bam-14214	30	1	4	4	NUM
bam-14214	30	2	sybr	sybr	VERB
bam-14214	30	3	green	green	ADJ
bam-14214	30	4	pcr	pcr	PROPN
bam-14214	30	5	master	master	NOUN
bam-14214	30	6	mix	mix	NOUN
bam-14214	30	7	(	(	PUNCT
bam-14214	30	8	biofact	biofact	PROPN
bam-14214	30	9	,	,	PUNCT
bam-14214	30	10	korea	korea	PROPN
bam-14214	30	11	)	)	PUNCT
bam-14214	30	12	was	be	AUX
bam-14214	30	13	used	use	VERB
bam-14214	30	14	for	for	ADP
bam-14214	30	15	qpcr	qpcr	ADJ
bam-14214	30	16	.	.	PUNCT
bam-14214	31	1	antibodies	antibody	NOUN
bam-14214	31	2	against	against	ADP
bam-14214	31	3	klotho	klotho	NOUN
bam-14214	31	4	,	,	PUNCT
bam-14214	31	5	hsp70	hsp70	NOUN
bam-14214	31	6	,	,	PUNCT
bam-14214	31	7	gapdh	gapdh	NOUN
bam-14214	31	8	,	,	PUNCT
bam-14214	31	9	and	and	CCONJ
bam-14214	31	10	hrp	hrp	PROPN
bam-14214	31	11	-	-	PUNCT
bam-14214	31	12	conjugated	conjugate	VERB
bam-14214	31	13	secondary	secondary	ADJ
bam-14214	31	14	antibodies	antibody	NOUN
bam-14214	31	15	were	be	AUX
bam-14214	31	16	obtained	obtain	VERB
bam-14214	31	17	from	from	ADP
bam-14214	31	18	santa	santa	PROPN
bam-14214	31	19	cruz	cruz	PROPN
bam-14214	31	20	biotechnology	biotechnology	PROPN
bam-14214	31	21	.	.	PUNCT
bam-14214	32	1	other	other	ADJ
bam-14214	32	2	reagents	reagent	NOUN
bam-14214	32	3	(	(	PUNCT
bam-14214	32	4	e.g.	e.g.	ADV
bam-14214	32	5	,	,	PUNCT
bam-14214	32	6	edta	edta	PROPN
bam-14214	32	7	,	,	PUNCT
bam-14214	32	8	triton	triton	PROPN
bam-14214	32	9	x-100	x-100	PROPN
bam-14214	32	10	)	)	PUNCT
bam-14214	32	11	were	be	AUX
bam-14214	32	12	analytical	analytical	ADJ
bam-14214	32	13	grade	grade	NOUN
bam-14214	32	14	(	(	PUNCT
bam-14214	32	15	sigma	sigma	PROPN
bam-14214	32	16	-	-	PUNCT
bam-14214	32	17	aldrich	aldrich	NOUN
bam-14214	32	18	)	)	PUNCT
bam-14214	32	19	.	.	PUNCT
bam-14214	33	1	animal	animal	NOUN
bam-14214	33	2	husbandry	husbandry	NOUN
bam-14214	33	3	and	and	CCONJ
bam-14214	33	4	experimental	experimental	ADJ
bam-14214	33	5	design	design	NOUN
bam-14214	33	6	seventy	seventy	NUM
bam-14214	33	7	-	-	PUNCT
bam-14214	33	8	six	six	NUM
bam-14214	33	9	adult	adult	NOUN
bam-14214	33	10	male	male	ADJ
bam-14214	33	11	nmri	nmri	ADJ
bam-14214	33	12	mice	mouse	NOUN
bam-14214	33	13	(	(	PUNCT
bam-14214	33	14	7	7	NUM
bam-14214	33	15	weeks	week	NOUN
bam-14214	33	16	old	old	ADJ
bam-14214	33	17	,	,	PUNCT
bam-14214	33	18	18±2	18±2	ADJ
bam-14214	33	19	g	g	NOUN
bam-14214	33	20	)	)	PUNCT
bam-14214	33	21	were	be	AUX
bam-14214	33	22	obtained	obtain	VERB
bam-14214	33	23	from	from	ADP
bam-14214	33	24	the	the	DET
bam-14214	33	25	pasteur	pasteur	PROPN
bam-14214	33	26	institute	institute	PROPN
bam-14214	33	27	of	of	ADP
bam-14214	33	28	iran	iran	PROPN
bam-14214	33	29	and	and	CCONJ
bam-14214	33	30	housed	house	VERB
bam-14214	33	31	under	under	ADP
bam-14214	33	32	standard	standard	ADJ
bam-14214	33	33	conditions	condition	NOUN
bam-14214	33	34	(	(	PUNCT
bam-14214	33	35	12	12	NUM
bam-14214	33	36	-	-	PUNCT
bam-14214	33	37	h	h	NOUN
bam-14214	33	38	light	light	ADJ
bam-14214	33	39	/	/	SYM
bam-14214	33	40	dark	dark	ADJ
bam-14214	33	41	cycle	cycle	NOUN
bam-14214	33	42	,	,	PUNCT
bam-14214	33	43	23±1	23±1	PROPN
bam-14214	33	44	°	°	ADP
bam-14214	33	45	c	c	NOUN
bam-14214	33	46	,	,	PUNCT
bam-14214	33	47	50±3	50±3	NUM
bam-14214	33	48	%	%	NOUN
bam-14214	33	49	humidity	humidity	NOUN
bam-14214	33	50	)	)	PUNCT
bam-14214	33	51	with	with	ADP
bam-14214	33	52	ad	ad	NOUN
bam-14214	33	53	libitum	libitum	X
bam-14214	33	54	food	food	NOUN
bam-14214	33	55	and	and	CCONJ
bam-14214	33	56	water	water	NOUN
bam-14214	33	57	.	.	PUNCT
bam-14214	34	1	after	after	ADP
bam-14214	34	2	a	a	DET
bam-14214	34	3	2	2	NUM
bam-14214	34	4	-	-	PUNCT
bam-14214	34	5	week	week	NOUN
bam-14214	34	6	acclimation	acclimation	NOUN
bam-14214	34	7	,	,	PUNCT
bam-14214	34	8	animals	animal	NOUN
bam-14214	34	9	were	be	AUX
bam-14214	34	10	assigned	assign	VERB
bam-14214	34	11	to	to	ADP
bam-14214	34	12	two	two	NUM
bam-14214	34	13	cohorts	cohort	NOUN
bam-14214	34	14	:	:	PUNCT
bam-14214	34	15	cohort	cohort	NOUN
bam-14214	34	16	1	1	NUM
bam-14214	34	17	(	(	PUNCT
bam-14214	34	18	n=28	n=28	ADJ
bam-14214	34	19	;	;	PUNCT
bam-14214	34	20	4	4	NUM
bam-14214	34	21	groups	group	NOUN
bam-14214	34	22	,	,	PUNCT
bam-14214	34	23	n=7	n=7	PROPN
bam-14214	34	24	):	):	PUNCT
bam-14214	34	25	molecular	molecular	ADJ
bam-14214	34	26	analyses	analysis	NOUN
bam-14214	34	27	(	(	PUNCT
bam-14214	34	28	gene	gene	NOUN
bam-14214	34	29	/	/	SYM
bam-14214	34	30	protein	protein	NOUN
bam-14214	34	31	expression	expression	NOUN
bam-14214	34	32	,	,	PUNCT
bam-14214	34	33	plasma	plasma	NOUN
bam-14214	34	34	irisin	irisin	NOUN
bam-14214	34	35	)	)	PUNCT
bam-14214	34	36	.	.	PUNCT
bam-14214	35	1	cohort	cohort	NOUN
bam-14214	35	2	2	2	NUM
bam-14214	35	3	(	(	PUNCT
bam-14214	35	4	n=48	n=48	NOUN
bam-14214	35	5	;	;	PUNCT
bam-14214	35	6	4	4	NUM
bam-14214	35	7	groups	group	NOUN
bam-14214	35	8	,	,	PUNCT
bam-14214	35	9	n=12	n=12	NOUN
bam-14214	35	10	):	):	PUNCT
bam-14214	35	11	survival	survival	NOUN
bam-14214	35	12	analysis	analysis	NOUN
bam-14214	35	13	over	over	ADP
bam-14214	35	14	20	20	NUM
bam-14214	35	15	months	month	NOUN
bam-14214	35	16	.	.	PUNCT
bam-14214	36	1	all	all	DET
bam-14214	36	2	protocols	protocol	NOUN
bam-14214	36	3	were	be	AUX
bam-14214	36	4	approved	approve	VERB
bam-14214	36	5	by	by	ADP
bam-14214	36	6	the	the	DET
bam-14214	36	7	animal	animal	NOUN
bam-14214	36	8	ethics	ethic	NOUN
bam-14214	36	9	committee	committee	PROPN
bam-14214	36	10	of	of	ADP
bam-14214	36	11	isfahan	isfahan	PROPN
bam-14214	36	12	university	university	PROPN
bam-14214	36	13	of	of	ADP
bam-14214	36	14	medical	medical	ADJ
bam-14214	36	15	sciences.13	sciences.13	NOUN
bam-14214	36	16	exercise	exercise	NOUN
bam-14214	36	17	training	training	NOUN
bam-14214	36	18	and	and	CCONJ
bam-14214	36	19	injection	injection	NOUN
bam-14214	36	20	protocol	protocol	NOUN
bam-14214	36	21	endurance	endurance	NOUN
bam-14214	36	22	training	training	NOUN
bam-14214	36	23	involved	involve	VERB
bam-14214	36	24	8	8	NUM
bam-14214	36	25	weeks	week	NOUN
bam-14214	36	26	of	of	ADP
bam-14214	36	27	treadmill	treadmill	NOUN
bam-14214	36	28	running	run	VERB
bam-14214	36	29	with	with	ADP
bam-14214	36	30	progressive	progressive	ADJ
bam-14214	36	31	intensity	intensity	NOUN
bam-14214	36	32	(	(	PUNCT
bam-14214	36	33	from	from	ADP
bam-14214	36	34	5	5	NUM
bam-14214	36	35	m	m	PROPN
bam-14214	36	36	/	/	SYM
bam-14214	36	37	min	min	PROPN
bam-14214	36	38	,	,	PUNCT
bam-14214	36	39	0	0	NUM
bam-14214	36	40	°	°	NUM
bam-14214	36	41	incline	incline	NOUN
bam-14214	36	42	,	,	PUNCT
bam-14214	36	43	10	10	NUM
bam-14214	36	44	min	min	NOUN
bam-14214	36	45	/	/	SYM
bam-14214	36	46	day	day	NOUN
bam-14214	36	47	to	to	ADP
bam-14214	36	48	10	10	NUM
bam-14214	36	49	m	m	PROPN
bam-14214	36	50	/	/	SYM
bam-14214	36	51	min	min	PROPN
bam-14214	36	52	,	,	PUNCT
bam-14214	36	53	5	5	NUM
bam-14214	36	54	°	°	NOUN
bam-14214	36	55	,	,	PUNCT
bam-14214	36	56	15	15	NUM
bam-14214	36	57	min	min	NOUN
bam-14214	36	58	/	/	SYM
bam-14214	36	59	day	day	NOUN
bam-14214	36	60	)	)	PUNCT
bam-14214	36	61	.	.	PUNCT
bam-14214	37	1	resistance	resistance	NOUN
bam-14214	37	2	training	training	NOUN
bam-14214	37	3	consisted	consist	VERB
bam-14214	37	4	of	of	ADP
bam-14214	37	5	ladder	ladder	NOUN
bam-14214	37	6	climbing	climbing	NOUN
bam-14214	37	7	(	(	PUNCT
bam-14214	37	8	80	80	NUM
bam-14214	37	9	°	°	NUM
bam-14214	37	10	incline	incline	NOUN
bam-14214	37	11	)	)	PUNCT
bam-14214	37	12	with	with	ADP
bam-14214	37	13	tail	tail	NOUN
bam-14214	37	14	weights	weight	NOUN
bam-14214	37	15	progressively	progressively	ADV
bam-14214	37	16	increased	increase	VERB
bam-14214	37	17	from	from	ADP
bam-14214	37	18	30	30	NUM
bam-14214	37	19	%	%	NOUN
bam-14214	37	20	to	to	ADP
bam-14214	37	21	200	200	NUM
bam-14214	37	22	%	%	NOUN
bam-14214	37	23	of	of	ADP
bam-14214	37	24	body	body	NOUN
bam-14214	37	25	weight	weight	NOUN
bam-14214	37	26	.	.	PUNCT
bam-14214	38	1	irisin	irisin	NOUN
bam-14214	38	2	-	-	PUNCT
bam-14214	38	3	treated	treat	VERB
bam-14214	38	4	mice	mouse	NOUN
bam-14214	38	5	received	receive	VERB
bam-14214	38	6	intraperitoneal	intraperitoneal	ADJ
bam-14214	38	7	injections	injection	NOUN
bam-14214	38	8	of	of	ADP
bam-14214	38	9	100	100	NUM
bam-14214	38	10	µg	µg	ADV
bam-14214	38	11	/	/	SYM
bam-14214	38	12	kg	kg	NOUN
bam-14214	38	13	recombinant	recombinant	ADJ
bam-14214	38	14	irisin	irisin	NOUN
bam-14214	38	15	(	(	PUNCT
bam-14214	38	16	in	in	ADP
bam-14214	38	17	1	1	NUM
bam-14214	38	18	%	%	NOUN
bam-14214	38	19	dmso	dmso	NOUN
bam-14214	38	20	)	)	PUNCT
bam-14214	38	21	,	,	PUNCT
bam-14214	38	22	three	three	NUM
bam-14214	38	23	times	time	NOUN
bam-14214	38	24	per	per	ADP
bam-14214	38	25	week	week	NOUN
bam-14214	38	26	for	for	ADP
bam-14214	38	27	8	8	NUM
bam-14214	38	28	weeks.12	weeks.12	NOUN
bam-14214	38	29	measurement	measurement	NOUN
bam-14214	38	30	of	of	ADP
bam-14214	38	31	plasma	plasma	NOUN
bam-14214	38	32	irisin	irisin	VERB
bam-14214	38	33	concentration	concentration	NOUN
bam-14214	38	34	seventy	seventy	NUM
bam-14214	38	35	-	-	PUNCT
bam-14214	38	36	two	two	NUM
bam-14214	38	37	hours	hour	NOUN
bam-14214	38	38	'	'	PART
bam-14214	38	39	post	post	NOUN
bam-14214	38	40	-	-	NOUN
bam-14214	38	41	intervention	intervention	NOUN
bam-14214	38	42	,	,	PUNCT
bam-14214	38	43	mice	mouse	NOUN
bam-14214	38	44	were	be	AUX
bam-14214	38	45	anesthetized	anesthetize	VERB
bam-14214	38	46	with	with	ADP
bam-14214	38	47	isoflurane	isoflurane	NOUN
bam-14214	38	48	(	(	PUNCT
bam-14214	38	49	2	2	NUM
bam-14214	38	50	%	%	NOUN
bam-14214	38	51	in	in	ADP
bam-14214	38	52	oxygen	oxygen	NOUN
bam-14214	38	53	)	)	PUNCT
bam-14214	38	54	,	,	PUNCT
bam-14214	38	55	and	and	CCONJ
bam-14214	38	56	blood	blood	NOUN
bam-14214	38	57	was	be	AUX
bam-14214	38	58	collected	collect	VERB
bam-14214	38	59	via	via	ADP
bam-14214	38	60	cardiac	cardiac	ADJ
bam-14214	38	61	puncture	puncture	NOUN
bam-14214	38	62	into	into	ADP
bam-14214	38	63	edta	edta	NOUN
bam-14214	38	64	tubes	tube	NOUN
bam-14214	38	65	.	.	PUNCT
bam-14214	39	1	samples	sample	NOUN
bam-14214	39	2	were	be	AUX
bam-14214	39	3	centrifuged	centrifuge	VERB
bam-14214	39	4	at	at	ADP
bam-14214	39	5	15	15	NUM
bam-14214	39	6	min	min	NOUN
bam-14214	39	7	at	at	ADP
bam-14214	39	8	4	4	NUM
bam-14214	39	9	°	°	NOUN
bam-14214	39	10	c	c	NOUN
bam-14214	39	11	,	,	PUNCT
bam-14214	39	12	and	and	CCONJ
bam-14214	39	13	the	the	DET
bam-14214	39	14	resulting	result	VERB
bam-14214	39	15	plasma	plasma	NOUN
bam-14214	39	16	was	be	AUX
bam-14214	39	17	stored	store	VERB
bam-14214	39	18	at	at	ADP
bam-14214	39	19	-80	-80	NOUN
bam-14214	39	20	°	°	NOUN
bam-14214	39	21	c	c	NOUN
bam-14214	39	22	until	until	ADP
bam-14214	39	23	analysis	analysis	NOUN
bam-14214	39	24	.	.	PUNCT
bam-14214	40	1	irisin	irisin	PROPN
bam-14214	40	2	concentrations	concentration	NOUN
bam-14214	40	3	were	be	AUX
bam-14214	40	4	measured	measure	VERB
bam-14214	40	5	using	use	VERB
bam-14214	40	6	a	a	DET
bam-14214	40	7	commercial	commercial	ADJ
bam-14214	40	8	elisa	elisa	NOUN
bam-14214	40	9	kit	kit	NOUN
bam-14214	40	10	(	(	PUNCT
bam-14214	40	11	phoenix	phoenix	PROPN
bam-14214	40	12	pharmaceuticals	pharmaceutical	NOUN
bam-14214	40	13	,	,	PUNCT
bam-14214	40	14	ca	ca	PROPN
bam-14214	40	15	,	,	PUNCT
bam-14214	40	16	usa	usa	PROPN
bam-14214	40	17	)	)	PUNCT
bam-14214	40	18	according	accord	VERB
bam-14214	40	19	to	to	ADP
bam-14214	40	20	the	the	DET
bam-14214	40	21	manufacturer	manufacturer	NOUN
bam-14214	40	22	's	's	PART
bam-14214	40	23	instructions	instruction	NOUN
bam-14214	40	24	.	.	PUNCT
bam-14214	41	1	sample	sample	NOUN
bam-14214	41	2	collection	collection	NOUN
bam-14214	41	3	and	and	CCONJ
bam-14214	41	4	protein	protein	NOUN
bam-14214	41	5	extraction	extraction	NOUN
bam-14214	41	6	seventy	seventy	NUM
bam-14214	41	7	-	-	PUNCT
bam-14214	41	8	two	two	NUM
bam-14214	41	9	hours	hour	NOUN
bam-14214	41	10	'	'	PART
bam-14214	41	11	post	post	NOUN
bam-14214	41	12	-	-	NOUN
bam-14214	41	13	intervention	intervention	NOUN
bam-14214	41	14	,	,	PUNCT
bam-14214	41	15	mice	mouse	NOUN
bam-14214	41	16	were	be	AUX
bam-14214	41	17	anesthetized	anesthetize	VERB
bam-14214	41	18	with	with	ADP
bam-14214	41	19	isoflurane	isoflurane	NOUN
bam-14214	41	20	(	(	PUNCT
bam-14214	41	21	2	2	NUM
bam-14214	41	22	%	%	NOUN
bam-14214	41	23	in	in	ADP
bam-14214	41	24	oxygen	oxygen	NOUN
bam-14214	41	25	)	)	PUNCT
bam-14214	41	26	,	,	PUNCT
bam-14214	41	27	and	and	CCONJ
bam-14214	41	28	kidney	kidney	NOUN
bam-14214	41	29	tissues	tissue	NOUN
bam-14214	41	30	were	be	AUX
bam-14214	41	31	excised	excise	VERB
bam-14214	41	32	,	,	PUNCT
bam-14214	41	33	snap	snap	NOUN
bam-14214	41	34	-	-	PUNCT
bam-14214	41	35	frozen	frozen	ADJ
bam-14214	41	36	in	in	ADP
bam-14214	41	37	liquid	liquid	ADJ
bam-14214	41	38	nitrogen	nitrogen	NOUN
bam-14214	41	39	,	,	PUNCT
bam-14214	41	40	and	and	CCONJ
bam-14214	41	41	stored	store	VERB
bam-14214	41	42	at	at	ADP
bam-14214	41	43	-80	-80	NOUN
bam-14214	41	44	°	°	NOUN
bam-14214	41	45	c	c	NOUN
bam-14214	41	46	.	.	PUNCT
bam-14214	42	1	for	for	ADP
bam-14214	42	2	protein	protein	NOUN
bam-14214	42	3	extraction	extraction	NOUN
bam-14214	42	4	,	,	PUNCT
bam-14214	42	5	50	50	NUM
bam-14214	42	6	-	-	SYM
bam-14214	42	7	100	100	NUM
bam-14214	42	8	mg	mg	NOUN
bam-14214	42	9	of	of	ADP
bam-14214	42	10	tissue	tissue	NOUN
bam-14214	42	11	was	be	AUX
bam-14214	42	12	homogenized	homogenize	VERB
bam-14214	42	13	in	in	ADP
bam-14214	42	14	ripa	ripa	ADJ
bam-14214	42	15	buffer	buffer	NOUN
bam-14214	42	16	(	(	PUNCT
bam-14214	42	17	50	50	NUM
bam-14214	42	18	mm	mm	NOUN
bam-14214	42	19	tris	tris	NOUN
bam-14214	42	20	-	-	PUNCT
bam-14214	42	21	hcl	hcl	NOUN
bam-14214	42	22	,	,	PUNCT
bam-14214	42	23	ph	ph	NOUN
bam-14214	42	24	7.4	7.4	NUM
bam-14214	42	25	,	,	PUNCT
bam-14214	42	26	150	150	NUM
bam-14214	42	27	5	5	NUM
bam-14214	42	28	mm	mm	NOUN
bam-14214	42	29	nacl	nacl	NOUN
bam-14214	42	30	,	,	PUNCT
bam-14214	42	31	1	1	NUM
bam-14214	42	32	%	%	NOUN
bam-14214	42	33	triton	triton	PROPN
bam-14214	42	34	x-100	x-100	PROPN
bam-14214	42	35	,	,	PUNCT
bam-14214	42	36	0.1	0.1	NUM
bam-14214	42	37	%	%	NOUN
bam-14214	42	38	sds	sds	NOUN
bam-14214	42	39	,	,	PUNCT
bam-14214	42	40	1	1	NUM
bam-14214	42	41	%	%	NOUN
bam-14214	42	42	sodium	sodium	NOUN
bam-14214	42	43	deoxycholate	deoxycholate	NOUN
bam-14214	42	44	)	)	PUNCT
bam-14214	42	45	supplemented	supplement	VERB
bam-14214	42	46	with	with	ADP
bam-14214	42	47	protease	protease	NOUN
bam-14214	42	48	/	/	SYM
bam-14214	42	49	phosphatase	phosphatase	NOUN
bam-14214	42	50	inhibitors	inhibitor	NOUN
bam-14214	42	51	(	(	PUNCT
bam-14214	42	52	roche	roche	PROPN
bam-14214	42	53	,	,	PUNCT
bam-14214	42	54	germany	germany	PROPN
bam-14214	42	55	)	)	PUNCT
bam-14214	42	56	.	.	PUNCT
bam-14214	43	1	homogenates	homogenate	NOUN
bam-14214	43	2	were	be	AUX
bam-14214	43	3	centrifuged	centrifuge	VERB
bam-14214	43	4	at	at	ADP
bam-14214	43	5	12,000	12,000	NUM
bam-14214	43	6	rpm	rpm	NOUN
bam-14214	43	7	for	for	ADP
bam-14214	43	8	20	20	NUM
bam-14214	43	9	min	min	NOUN
bam-14214	43	10	at	at	ADP
bam-14214	43	11	4	4	NUM
bam-14214	43	12	°	°	NOUN
bam-14214	43	13	c	c	NOUN
bam-14214	43	14	,	,	PUNCT
bam-14214	43	15	and	and	CCONJ
bam-14214	43	16	supernatants	supernatant	NOUN
bam-14214	43	17	were	be	AUX
bam-14214	43	18	quantified	quantify	VERB
bam-14214	43	19	using	use	VERB
bam-14214	43	20	the	the	DET
bam-14214	43	21	bca	bca	PROPN
bam-14214	43	22	assay	assay	PROPN
bam-14214	43	23	(	(	PUNCT
bam-14214	43	24	thermo	thermo	NOUN
bam-14214	43	25	fisher	fisher	PROPN
bam-14214	43	26	scientific	scientific	PROPN
bam-14214	43	27	,	,	PUNCT
bam-14214	43	28	usa	usa	PROPN
bam-14214	43	29	)	)	PUNCT
bam-14214	43	30	.	.	PUNCT
bam-14214	44	1	real	real	ADJ
bam-14214	44	2	-	-	PUNCT
bam-14214	44	3	time	time	NOUN
bam-14214	44	4	pcr	pcr	NOUN
bam-14214	44	5	for	for	ADP
bam-14214	44	6	klotho	klotho	PROPN
bam-14214	44	7	and	and	CCONJ
bam-14214	44	8	hsp70	hsp70	NOUN
bam-14214	44	9	gene	gene	NOUN
bam-14214	44	10	expression	expression	NOUN
bam-14214	44	11	quantification	quantification	NOUN
bam-14214	44	12	total	total	NOUN
bam-14214	44	13	rna	rna	NOUN
bam-14214	44	14	was	be	AUX
bam-14214	44	15	extracted	extract	VERB
bam-14214	44	16	from	from	ADP
bam-14214	44	17	kidney	kidney	NOUN
bam-14214	44	18	tissue	tissue	NOUN
bam-14214	44	19	using	use	VERB
bam-14214	44	20	trizol	trizol	ADJ
bam-14214	44	21	reagent	reagent	ADJ
bam-14214	44	22	(	(	PUNCT
bam-14214	44	23	thermo	thermo	NOUN
bam-14214	44	24	fisher	fisher	PROPN
bam-14214	44	25	scientific	scientific	PROPN
bam-14214	44	26	,	,	PUNCT
bam-14214	44	27	usa	usa	PROPN
bam-14214	44	28	)	)	PUNCT
bam-14214	44	29	,	,	PUNCT
bam-14214	44	30	and	and	CCONJ
bam-14214	44	31	1	1	NUM
bam-14214	44	32	μg	μg	PROPN
bam-14214	44	33	rna	rna	PROPN
bam-14214	44	34	was	be	AUX
bam-14214	44	35	reverse	reverse	NOUN
bam-14214	44	36	-	-	PUNCT
bam-14214	44	37	transcribed	transcribe	VERB
bam-14214	44	38	into	into	ADP
bam-14214	44	39	cdna	cdna	PROPN
bam-14214	44	40	(	(	PUNCT
bam-14214	44	41	thermo	thermo	NOUN
bam-14214	44	42	fisher	fisher	PROPN
bam-14214	44	43	scientific	scientific	PROPN
bam-14214	44	44	,	,	PUNCT
bam-14214	44	45	usa	usa	PROPN
bam-14214	44	46	)	)	PUNCT
bam-14214	44	47	.	.	PUNCT
bam-14214	45	1	qpcr	qpcr	ADV
bam-14214	45	2	was	be	AUX
bam-14214	45	3	performed	perform	VERB
bam-14214	45	4	on	on	ADP
bam-14214	45	5	an	an	DET
bam-14214	45	6	abi	abi	PROPN
bam-14214	45	7	steponeplus	steponeplus	ADJ
bam-14214	45	8	system	system	NOUN
bam-14214	45	9	using	use	VERB
bam-14214	45	10	sybr	sybr	ADP
bam-14214	45	11	green	green	ADJ
bam-14214	45	12	master	master	NOUN
bam-14214	45	13	mix	mix	NOUN
bam-14214	45	14	(	(	PUNCT
bam-14214	45	15	biofact	biofact	PROPN
bam-14214	45	16	,	,	PUNCT
bam-14214	45	17	korea	korea	PROPN
bam-14214	45	18	)	)	PUNCT
bam-14214	45	19	with	with	ADP
bam-14214	45	20	primers	primer	NOUN
bam-14214	45	21	for	for	ADP
bam-14214	45	22	klotho	klotho	X
bam-14214	45	23	(	(	PUNCT
bam-14214	45	24	f	f	X
bam-14214	45	25	:	:	PUNCT
bam-14214	45	26	5'-ctgcagtgaagcagtgtgga-3	5'-ctgcagtgaagcagtgtgga-3	NUM
bam-14214	45	27	'	'	NUM
bam-14214	45	28	,	,	PUNCT
bam-14214	45	29	r	r	NOUN
bam-14214	45	30	:	:	PUNCT
bam-14214	45	31	5'tgtcgagcggagttcagc-3	5'tgtcgagcggagttcagc-3	NUM
bam-14214	45	32	'	'	NUM
bam-14214	45	33	)	)	PUNCT
bam-14214	45	34	,	,	PUNCT
bam-14214	45	35	hsp70	hsp70	NOUN
bam-14214	45	36	(	(	PUNCT
bam-14214	45	37	f	f	NOUN
bam-14214	45	38	:	:	PUNCT
bam-14214	45	39	5'-ggtggaatgagcggagtacc-3	5'-ggtggaatgagcggagtacc-3	NUM
bam-14214	45	40	'	'	PUNCT
bam-14214	45	41	,	,	PUNCT
bam-14214	46	1	r	r	NOUN
bam-14214	46	2	:	:	PUNCT
bam-14214	46	3	5'cctgtccagttcgtcacagt-3	5'cctgtccagttcgtcacagt-3	NUM
bam-14214	46	4	'	'	NUM
bam-14214	46	5	)	)	PUNCT
bam-14214	46	6	,	,	PUNCT
bam-14214	46	7	and	and	CCONJ
bam-14214	46	8	gapdh	gapdh	NOUN
bam-14214	46	9	(	(	PUNCT
bam-14214	46	10	f	f	NOUN
bam-14214	46	11	:	:	PUNCT
bam-14214	46	12	5'-cagaacatcatcccagcctcc-3	5'-cagaacatcatcccagcctcc-3	NUM
bam-14214	46	13	'	'	PUNCT
bam-14214	46	14	,	,	PUNCT
bam-14214	47	1	r	r	NOUN
bam-14214	47	2	:	:	PUNCT
bam-14214	47	3	5'-ttggcaggtttctcaagacgg-3	5'-ttggcaggtttctcaagacgg-3	NUM
bam-14214	47	4	'	'	NUM
bam-14214	47	5	)	)	PUNCT
bam-14214	47	6	.	.	PUNCT
bam-14214	48	1	the	the	DET
bam-14214	48	2	amplification	amplification	NOUN
bam-14214	48	3	protocol	protocol	NOUN
bam-14214	48	4	consisted	consist	VERB
bam-14214	48	5	of	of	ADP
bam-14214	48	6	an	an	DET
bam-14214	48	7	initial	initial	ADJ
bam-14214	48	8	denaturation	denaturation	NOUN
bam-14214	48	9	at	at	ADP
bam-14214	48	10	95	95	NUM
bam-14214	48	11	°	°	ADP
bam-14214	48	12	c	c	NOUN
bam-14214	48	13	for	for	ADP
bam-14214	48	14	10	10	NUM
bam-14214	48	15	min	min	NOUN
bam-14214	48	16	,	,	PUNCT
bam-14214	48	17	followed	follow	VERB
bam-14214	48	18	by	by	ADP
bam-14214	48	19	40	40	NUM
bam-14214	48	20	cycles	cycle	NOUN
bam-14214	48	21	of	of	ADP
bam-14214	48	22	95	95	NUM
bam-14214	48	23	°	°	ADP
bam-14214	48	24	c	c	NOUN
bam-14214	48	25	for	for	ADP
bam-14214	48	26	15	15	NUM
bam-14214	48	27	s	s	NOUN
bam-14214	48	28	and	and	CCONJ
bam-14214	49	1	60	60	NUM
bam-14214	49	2	°	°	ADP
bam-14214	49	3	c	c	NOUN
bam-14214	49	4	for	for	ADP
bam-14214	49	5	40	40	NUM
bam-14214	49	6	s.	s.	PROPN
bam-14214	49	7	relative	relative	ADJ
bam-14214	49	8	gene	gene	NOUN
bam-14214	49	9	expression	expression	NOUN
bam-14214	49	10	was	be	AUX
bam-14214	49	11	calculated	calculate	VERB
bam-14214	49	12	using	use	VERB
bam-14214	49	13	the	the	DET
bam-14214	49	14	2−δδct	2−δδct	NUM
bam-14214	49	15	method	method	NOUN
bam-14214	49	16	,	,	PUNCT
bam-14214	49	17	with	with	ADP
bam-14214	49	18	gapdh	gapdh	NOUN
bam-14214	49	19	as	as	ADP
bam-14214	49	20	the	the	DET
bam-14214	49	21	housekeeping	housekeeping	NOUN
bam-14214	49	22	gene	gene	NOUN
bam-14214	49	23	for	for	ADP
bam-14214	49	24	normalization	normalization	NOUN
bam-14214	49	25	.	.	PUNCT
bam-14214	50	1	western	western	ADJ
bam-14214	50	2	blot	blot	NOUN
bam-14214	50	3	analysis	analysis	NOUN
bam-14214	50	4	of	of	ADP
bam-14214	50	5	protein	protein	NOUN
bam-14214	50	6	expression	expression	NOUN
bam-14214	50	7	western	western	ADJ
bam-14214	50	8	blot	blot	NOUN
bam-14214	50	9	analysis	analysis	NOUN
bam-14214	50	10	was	be	AUX
bam-14214	50	11	used	use	VERB
bam-14214	50	12	to	to	PART
bam-14214	50	13	measure	measure	VERB
bam-14214	50	14	the	the	DET
bam-14214	50	15	expression	expression	NOUN
bam-14214	50	16	levels	level	NOUN
bam-14214	50	17	of	of	ADP
bam-14214	50	18	the	the	DET
bam-14214	50	19	klotho	klotho	NOUN
bam-14214	50	20	,	,	PUNCT
bam-14214	50	21	hsp70	hsp70	NOUN
bam-14214	50	22	,	,	PUNCT
bam-14214	50	23	and	and	CCONJ
bam-14214	50	24	gapdh	gapdh	NOUN
bam-14214	50	25	proteins	protein	NOUN
bam-14214	50	26	.	.	PUNCT
bam-14214	51	1	proteins	protein	NOUN
bam-14214	51	2	(	(	PUNCT
bam-14214	51	3	30	30	NUM
bam-14214	51	4	μg	μg	NOUN
bam-14214	51	5	)	)	PUNCT
bam-14214	51	6	were	be	AUX
bam-14214	51	7	separated	separate	VERB
bam-14214	51	8	by	by	ADP
bam-14214	51	9	12	12	NUM
bam-14214	51	10	%	%	NOUN
bam-14214	51	11	sds	sds	NOUN
bam-14214	51	12	-	-	PUNCT
bam-14214	51	13	page	page	NOUN
bam-14214	51	14	,	,	PUNCT
bam-14214	51	15	transferred	transfer	VERB
bam-14214	51	16	to	to	ADP
bam-14214	51	17	nitrocellulose	nitrocellulose	NOUN
bam-14214	51	18	membranes	membrane	NOUN
bam-14214	51	19	(	(	PUNCT
bam-14214	51	20	bio	bio	NOUN
bam-14214	51	21	-	-	NOUN
bam-14214	51	22	rad	rad	PROPN
bam-14214	51	23	,	,	PUNCT
bam-14214	51	24	ca	ca	PROPN
bam-14214	51	25	,	,	PUNCT
bam-14214	51	26	usa	usa	PROPN
bam-14214	51	27	)	)	PUNCT
bam-14214	51	28	,	,	PUNCT
bam-14214	51	29	and	and	CCONJ
bam-14214	51	30	blocked	block	VERB
bam-14214	51	31	with	with	ADP
bam-14214	51	32	5	5	NUM
bam-14214	51	33	%	%	NOUN
bam-14214	51	34	non	non	ADJ
bam-14214	51	35	-	-	ADJ
bam-14214	51	36	fat	fat	ADJ
bam-14214	51	37	milk	milk	NOUN
bam-14214	51	38	in	in	ADP
bam-14214	51	39	tbst	tbst	VERB
bam-14214	51	40	.	.	PUNCT
bam-14214	52	1	membranes	membrane	NOUN
bam-14214	52	2	were	be	AUX
bam-14214	52	3	probed	probe	VERB
bam-14214	52	4	with	with	ADP
bam-14214	52	5	anti	anti	ADJ
bam-14214	52	6	-	-	ADJ
bam-14214	52	7	klotho	klotho	ADJ
bam-14214	52	8	(	(	PUNCT
bam-14214	52	9	1:1000	1:1000	NUM
bam-14214	52	10	)	)	PUNCT
bam-14214	52	11	,	,	PUNCT
bam-14214	52	12	anti	anti	ADJ
bam-14214	52	13	-	-	ADJ
bam-14214	52	14	hsp70	hsp70	NOUN
bam-14214	52	15	(	(	PUNCT
bam-14214	52	16	1:1000	1:1000	NUM
bam-14214	52	17	)	)	PUNCT
bam-14214	52	18	,	,	PUNCT
bam-14214	52	19	and	and	CCONJ
bam-14214	52	20	anti	anti	ADJ
bam-14214	52	21	-	-	ADJ
bam-14214	52	22	gapdh	gapdh	ADJ
bam-14214	52	23	(	(	PUNCT
bam-14214	52	24	1:2000	1:2000	NUM
bam-14214	52	25	)	)	PUNCT
bam-14214	52	26	antibodies	antibody	NOUN
bam-14214	52	27	(	(	PUNCT
bam-14214	52	28	santa	santa	PROPN
bam-14214	52	29	cruz	cruz	PROPN
bam-14214	52	30	biotechnology	biotechnology	PROPN
bam-14214	52	31	,	,	PUNCT
bam-14214	52	32	ca	ca	PROPN
bam-14214	52	33	,	,	PUNCT
bam-14214	52	34	usa	usa	PROPN
bam-14214	52	35	)	)	PUNCT
bam-14214	52	36	overnight	overnight	ADV
bam-14214	52	37	at	at	ADP
bam-14214	52	38	4	4	NUM
bam-14214	52	39	°	°	NOUN
bam-14214	52	40	c	c	NOUN
bam-14214	52	41	,	,	PUNCT
bam-14214	52	42	followed	follow	VERB
bam-14214	52	43	by	by	ADP
bam-14214	52	44	hrp	hrp	PROPN
bam-14214	52	45	-	-	PUNCT
bam-14214	52	46	conjugated	conjugate	VERB
bam-14214	52	47	secondary	secondary	ADJ
bam-14214	52	48	antibodies	antibody	NOUN
bam-14214	52	49	(	(	PUNCT
bam-14214	52	50	1:5000	1:5000	NUM
bam-14214	52	51	)	)	PUNCT
bam-14214	52	52	for	for	ADP
bam-14214	52	53	1	1	NUM
bam-14214	52	54	h	h	NOUN
bam-14214	52	55	at	at	ADP
bam-14214	52	56	room	room	NOUN
bam-14214	52	57	temperature	temperature	NOUN
bam-14214	52	58	.	.	PUNCT
bam-14214	53	1	bands	band	NOUN
bam-14214	53	2	were	be	AUX
bam-14214	53	3	visualized	visualize	VERB
bam-14214	53	4	using	use	VERB
bam-14214	53	5	an	an	DET
bam-14214	53	6	ecl	ecl	NOUN
bam-14214	53	7	kit	kit	NOUN
bam-14214	53	8	(	(	PUNCT
bam-14214	53	9	ge	ge	PROPN
bam-14214	53	10	amersham	amersham	PROPN
bam-14214	53	11	,	,	PUNCT
bam-14214	53	12	uk	uk	PROPN
bam-14214	53	13	)	)	PUNCT
bam-14214	53	14	and	and	CCONJ
bam-14214	53	15	quantified	quantify	VERB
bam-14214	53	16	with	with	ADP
bam-14214	53	17	imagej	imagej	ADJ
bam-14214	53	18	software	software	NOUN
bam-14214	53	19	,	,	PUNCT
bam-14214	53	20	normalized	normalize	VERB
bam-14214	53	21	to	to	AUX
bam-14214	53	22	gapdh	gapdh	VERB
bam-14214	53	23	.	.	PUNCT
bam-14214	54	1	survival	survival	NOUN
bam-14214	54	2	analysis	analysis	NOUN
bam-14214	54	3	following	follow	VERB
bam-14214	54	4	the	the	DET
bam-14214	54	5	8	8	NUM
bam-14214	54	6	-	-	PUNCT
bam-14214	54	7	week	week	NOUN
bam-14214	54	8	interventions	intervention	NOUN
bam-14214	54	9	,	,	PUNCT
bam-14214	54	10	mice	mouse	NOUN
bam-14214	54	11	from	from	ADP
bam-14214	54	12	cohort	cohort	NOUN
bam-14214	54	13	2	2	NUM
bam-14214	54	14	were	be	AUX
bam-14214	54	15	observed	observe	VERB
bam-14214	54	16	under	under	ADP
bam-14214	54	17	standard	standard	ADJ
bam-14214	54	18	housing	housing	NOUN
bam-14214	54	19	for	for	ADP
bam-14214	54	20	20	20	NUM
bam-14214	54	21	months	month	NOUN
bam-14214	54	22	.	.	PUNCT
bam-14214	55	1	no	no	DET
bam-14214	55	2	further	further	ADJ
bam-14214	55	3	treatments	treatment	NOUN
bam-14214	55	4	were	be	AUX
bam-14214	55	5	administered	administer	VERB
bam-14214	55	6	.	.	PUNCT
bam-14214	56	1	survival	survival	NOUN
bam-14214	56	2	was	be	AUX
bam-14214	56	3	defined	define	VERB
bam-14214	56	4	as	as	ADP
bam-14214	56	5	natural	natural	ADJ
bam-14214	56	6	death	death	NOUN
bam-14214	56	7	or	or	CCONJ
bam-14214	56	8	humane	humane	ADJ
bam-14214	56	9	euthanasia	euthanasia	NOUN
bam-14214	56	10	due	due	ADP
bam-14214	56	11	to	to	ADP
bam-14214	56	12	severe	severe	ADJ
bam-14214	56	13	morbidity	morbidity	NOUN
bam-14214	56	14	.	.	PUNCT
bam-14214	57	1	data	datum	NOUN
bam-14214	57	2	were	be	AUX
bam-14214	57	3	analyzed	analyze	VERB
bam-14214	57	4	using	use	VERB
bam-14214	57	5	the	the	DET
bam-14214	57	6	kaplan	kaplan	PROPN
bam-14214	57	7	-	-	PUNCT
bam-14214	57	8	meier	meier	PROPN
bam-14214	57	9	method	method	NOUN
bam-14214	57	10	;	;	PUNCT
bam-14214	57	11	6	6	NUM
bam-14214	57	12	differences	difference	NOUN
bam-14214	57	13	between	between	ADP
bam-14214	57	14	groups	group	NOUN
bam-14214	57	15	were	be	AUX
bam-14214	57	16	assessed	assess	VERB
bam-14214	57	17	using	use	VERB
bam-14214	57	18	the	the	DET
bam-14214	57	19	log	log	NOUN
bam-14214	57	20	-	-	PUNCT
bam-14214	57	21	rank	rank	NOUN
bam-14214	57	22	(	(	PUNCT
bam-14214	57	23	mantel	mantel	NOUN
bam-14214	57	24	-	-	PUNCT
bam-14214	57	25	cox	cox	NOUN
bam-14214	57	26	)	)	PUNCT
bam-14214	57	27	,	,	PUNCT
bam-14214	57	28	gehan	gehan	NOUN
bam-14214	57	29	–	–	PUNCT
bam-14214	57	30	breslow	breslow	ADJ
bam-14214	57	31	–	–	PUNCT
bam-14214	57	32	wilcoxon	wilcoxon	ADJ
bam-14214	57	33	,	,	PUNCT
bam-14214	57	34	and	and	CCONJ
bam-14214	57	35	trend	trend	NOUN
bam-14214	57	36	tests	test	NOUN
bam-14214	57	37	(	(	PUNCT
bam-14214	57	38	graphpad	graphpad	NOUN
bam-14214	57	39	prism	prism	NOUN
bam-14214	57	40	8.0	8.0	NUM
bam-14214	57	41	)	)	PUNCT
bam-14214	57	42	.	.	PUNCT
bam-14214	58	1	statistical	statistical	ADJ
bam-14214	58	2	significance	significance	NOUN
bam-14214	58	3	was	be	AUX
bam-14214	58	4	set	set	VERB
bam-14214	58	5	at	at	ADP
bam-14214	58	6	p<0.05	p<0.05	NOUN
bam-14214	58	7	.	.	PUNCT
bam-14214	59	1	statistical	statistical	ADJ
bam-14214	59	2	analyses	analysis	NOUN
bam-14214	59	3	group	group	NOUN
bam-14214	59	4	comparisons	comparison	NOUN
bam-14214	59	5	for	for	ADP
bam-14214	59	6	molecular	molecular	ADJ
bam-14214	59	7	data	datum	NOUN
bam-14214	59	8	were	be	AUX
bam-14214	59	9	performed	perform	VERB
bam-14214	59	10	using	use	VERB
bam-14214	59	11	one	one	NUM
bam-14214	59	12	-	-	PUNCT
bam-14214	59	13	way	way	NOUN
bam-14214	59	14	anova	anova	X
bam-14214	59	15	with	with	ADP
bam-14214	59	16	tukey	tukey	PROPN
bam-14214	59	17	’s	’s	PART
bam-14214	59	18	posthoc	posthoc	NOUN
bam-14214	59	19	test	test	NOUN
bam-14214	59	20	.	.	PUNCT
bam-14214	60	1	pearson	pearson	PROPN
bam-14214	60	2	correlation	correlation	NOUN
bam-14214	60	3	was	be	AUX
bam-14214	60	4	used	use	VERB
bam-14214	60	5	to	to	PART
bam-14214	60	6	examine	examine	VERB
bam-14214	60	7	relationships	relationship	NOUN
bam-14214	60	8	between	between	ADP
bam-14214	60	9	plasma	plasma	NOUN
bam-14214	60	10	irisin	irisin	NOUN
bam-14214	60	11	and	and	CCONJ
bam-14214	60	12	gene	gene	NOUN
bam-14214	60	13	expression	expression	NOUN
bam-14214	60	14	.	.	PUNCT
bam-14214	61	1	all	all	DET
bam-14214	61	2	results	result	NOUN
bam-14214	61	3	are	be	AUX
bam-14214	61	4	reported	report	VERB
bam-14214	61	5	as	as	ADP
bam-14214	61	6	mean±sd	mean±sd	ADP
bam-14214	61	7	or	or	CCONJ
bam-14214	61	8	survival	survival	NOUN
bam-14214	61	9	curves	curve	NOUN
bam-14214	61	10	as	as	ADP
bam-14214	61	11	appropriate	appropriate	ADJ
bam-14214	61	12	.	.	PUNCT
bam-14214	62	1	results	result	VERB
bam-14214	62	2	plasma	plasma	NOUN
bam-14214	62	3	irisin	irisin	PROPN
bam-14214	62	4	levels	level	NOUN
bam-14214	62	5	plasma	plasma	NOUN
bam-14214	62	6	irisin	irisin	PROPN
bam-14214	62	7	levels	level	NOUN
bam-14214	62	8	were	be	AUX
bam-14214	62	9	significantly	significantly	ADV
bam-14214	62	10	elevated	elevate	VERB
bam-14214	62	11	in	in	ADP
bam-14214	62	12	all	all	DET
bam-14214	62	13	intervention	intervention	NOUN
bam-14214	62	14	groups	group	NOUN
bam-14214	62	15	compared	compare	VERB
bam-14214	62	16	to	to	ADP
bam-14214	62	17	the	the	DET
bam-14214	62	18	control	control	NOUN
bam-14214	62	19	group	group	NOUN
bam-14214	62	20	(	(	PUNCT
bam-14214	62	21	4.35±0.45	4.35±0.45	PROPN
bam-14214	62	22	ng	ng	PROPN
bam-14214	62	23	/	/	SYM
bam-14214	62	24	ml	ml	PROPN
bam-14214	62	25	,	,	PUNCT
bam-14214	62	26	p<0.0001	p<0.0001	NOUN
bam-14214	62	27	)	)	PUNCT
bam-14214	62	28	.	.	PUNCT
bam-14214	63	1	the	the	DET
bam-14214	63	2	endurance	endurance	NOUN
bam-14214	63	3	exercise	exercise	NOUN
bam-14214	63	4	group	group	NOUN
bam-14214	63	5	showed	show	VERB
bam-14214	63	6	a	a	DET
bam-14214	63	7	46.7	46.7	NUM
bam-14214	63	8	%	%	NOUN
bam-14214	63	9	increase	increase	NOUN
bam-14214	63	10	,	,	PUNCT
bam-14214	63	11	with	with	ADP
bam-14214	63	12	a	a	DET
bam-14214	63	13	mean	mean	ADJ
bam-14214	63	14	concentration	concentration	NOUN
bam-14214	63	15	of	of	ADP
bam-14214	63	16	6.38±0.65	6.38±0.65	NUM
bam-14214	63	17	ng	ng	PROPN
bam-14214	63	18	/	/	SYM
bam-14214	63	19	ml	ml	PROPN
bam-14214	63	20	,	,	PUNCT
bam-14214	63	21	while	while	SCONJ
bam-14214	63	22	the	the	DET
bam-14214	63	23	resistance	resistance	NOUN
bam-14214	63	24	exercise	exercise	NOUN
bam-14214	63	25	group	group	NOUN
bam-14214	63	26	exhibited	exhibit	VERB
bam-14214	63	27	the	the	DET
bam-14214	63	28	greatest	great	ADJ
bam-14214	63	29	rise	rise	NOUN
bam-14214	63	30	(	(	PUNCT
bam-14214	63	31	65.5	65.5	NUM
bam-14214	63	32	%	%	NOUN
bam-14214	63	33	)	)	PUNCT
bam-14214	63	34	,	,	PUNCT
bam-14214	63	35	reaching	reach	VERB
bam-14214	63	36	7.42±0.35	7.42±0.35	PROPN
bam-14214	63	37	ng	ng	PROPN
bam-14214	63	38	/	/	SYM
bam-14214	63	39	ml	ml	PROPN
bam-14214	63	40	.	.	PUNCT
bam-14214	64	1	the	the	DET
bam-14214	64	2	irisin	irisin	PROPN
bam-14214	64	3	injection	injection	NOUN
bam-14214	64	4	group	group	NOUN
bam-14214	64	5	displayed	display	VERB
bam-14214	64	6	a	a	DET
bam-14214	64	7	62.1	62.1	NUM
bam-14214	64	8	%	%	NOUN
bam-14214	64	9	increase	increase	NOUN
bam-14214	64	10	,	,	PUNCT
bam-14214	64	11	with	with	ADP
bam-14214	64	12	levels	level	NOUN
bam-14214	64	13	at	at	ADP
bam-14214	64	14	7.27±0.66	7.27±0.66	PROPN
bam-14214	64	15	ng	ng	PROPN
bam-14214	64	16	/	/	SYM
bam-14214	64	17	ml	ml	PROPN
bam-14214	64	18	.	.	PUNCT
bam-14214	65	1	no	no	DET
bam-14214	65	2	significant	significant	ADJ
bam-14214	65	3	differences	difference	NOUN
bam-14214	65	4	were	be	AUX
bam-14214	65	5	observed	observe	VERB
bam-14214	65	6	among	among	ADP
bam-14214	65	7	the	the	DET
bam-14214	65	8	intervention	intervention	NOUN
bam-14214	65	9	groups	group	NOUN
bam-14214	65	10	(	(	PUNCT
bam-14214	65	11	p>0.05	p>0.05	PROPN
bam-14214	65	12	)	)	PUNCT
bam-14214	65	13	.	.	PUNCT
bam-14214	66	1	these	these	DET
bam-14214	66	2	data	datum	NOUN
bam-14214	66	3	are	be	AUX
bam-14214	66	4	presented	present	VERB
bam-14214	66	5	in	in	ADP
bam-14214	66	6	figure	figure	NOUN
bam-14214	66	7	1	1	NUM
bam-14214	66	8	,	,	PUNCT
bam-14214	66	9	which	which	PRON
bam-14214	66	10	illustrates	illustrate	VERB
bam-14214	66	11	the	the	DET
bam-14214	66	12	mean	mean	ADJ
bam-14214	66	13	plasma	plasma	NOUN
bam-14214	66	14	irisin	irisin	VERB
bam-14214	66	15	concentrations	concentration	NOUN
bam-14214	66	16	across	across	ADP
bam-14214	66	17	all	all	DET
bam-14214	66	18	groups	group	NOUN
bam-14214	66	19	.	.	PUNCT
bam-14214	67	1	renal	renal	ADJ
bam-14214	67	2	mrna	mrna	PROPN
bam-14214	67	3	expression	expression	NOUN
bam-14214	67	4	of	of	ADP
bam-14214	67	5	klotho	klotho	PROPN
bam-14214	67	6	and	and	CCONJ
bam-14214	67	7	hsp70	hsp70	PROPN
bam-14214	67	8	real	real	ADJ
bam-14214	67	9	-	-	PUNCT
bam-14214	67	10	time	time	NOUN
bam-14214	67	11	pcr	pcr	ADJ
bam-14214	67	12	analysis	analysis	NOUN
bam-14214	67	13	revealed	reveal	VERB
bam-14214	67	14	significant	significant	ADJ
bam-14214	67	15	upregulation	upregulation	NOUN
bam-14214	67	16	of	of	ADP
bam-14214	67	17	klotho	klotho	PROPN
bam-14214	67	18	and	and	CCONJ
bam-14214	67	19	hsp70	hsp70	PROPN
bam-14214	67	20	mrna	mrna	PROPN
bam-14214	67	21	in	in	ADP
bam-14214	67	22	kidney	kidney	NOUN
bam-14214	67	23	tissues	tissue	NOUN
bam-14214	67	24	across	across	ADP
bam-14214	67	25	all	all	DET
bam-14214	67	26	intervention	intervention	NOUN
bam-14214	67	27	groups	group	NOUN
bam-14214	67	28	compared	compare	VERB
bam-14214	67	29	to	to	ADP
bam-14214	67	30	control	control	NOUN
bam-14214	67	31	(	(	PUNCT
bam-14214	67	32	p<0.001	p<0.001	PROPN
bam-14214	67	33	)	)	PUNCT
bam-14214	67	34	.	.	PUNCT
bam-14214	68	1	klotho	klotho	PROPN
bam-14214	68	2	mrna	mrna	PROPN
bam-14214	68	3	expression	expression	NOUN
bam-14214	68	4	increased	increase	VERB
bam-14214	68	5	by	by	ADP
bam-14214	68	6	2.12±0.3	2.12±0.3	PROPN
bam-14214	68	7	-	-	NOUN
bam-14214	68	8	fold	fold	ADJ
bam-14214	68	9	in	in	ADP
bam-14214	68	10	the	the	DET
bam-14214	68	11	endurance	endurance	NOUN
bam-14214	68	12	exercise	exercise	NOUN
bam-14214	68	13	group	group	NOUN
bam-14214	68	14	,	,	PUNCT
bam-14214	68	15	3.85±0.5	3.85±0.5	PROPN
bam-14214	68	16	-	-	NOUN
bam-14214	68	17	fold	fold	ADJ
bam-14214	68	18	in	in	ADP
bam-14214	68	19	the	the	DET
bam-14214	68	20	resistance	resistance	NOUN
bam-14214	68	21	exercise	exercise	NOUN
bam-14214	68	22	group	group	NOUN
bam-14214	68	23	,	,	PUNCT
bam-14214	68	24	and	and	CCONJ
bam-14214	68	25	3.31±0.4	3.31±0.4	NUM
bam-14214	68	26	-	-	ADJ
bam-14214	68	27	fold	fold	ADJ
bam-14214	68	28	in	in	ADP
bam-14214	68	29	the	the	DET
bam-14214	68	30	irisin	irisin	NOUN
bam-14214	68	31	injection	injection	NOUN
bam-14214	68	32	group	group	NOUN
bam-14214	68	33	,	,	PUNCT
bam-14214	68	34	relative	relative	ADJ
bam-14214	68	35	to	to	ADP
bam-14214	68	36	control	control	NOUN
bam-14214	68	37	(	(	PUNCT
bam-14214	68	38	1.0±0.1	1.0±0.1	NUM
bam-14214	68	39	)	)	PUNCT
bam-14214	68	40	.	.	PUNCT
bam-14214	69	1	compared	compare	VERB
bam-14214	69	2	to	to	ADP
bam-14214	69	3	irisin	irisin	VERB
bam-14214	69	4	injection	injection	NOUN
bam-14214	69	5	,	,	PUNCT
bam-14214	69	6	resistance	resistance	NOUN
bam-14214	69	7	exercise	exercise	NOUN
bam-14214	69	8	significantly	significantly	ADV
bam-14214	69	9	increased	increase	VERB
bam-14214	69	10	klotho	klotho	ADJ
bam-14214	69	11	expression	expression	NOUN
bam-14214	69	12	(	(	PUNCT
bam-14214	69	13	p<0.05	p<0.05	NOUN
bam-14214	69	14	)	)	PUNCT
bam-14214	69	15	,	,	PUNCT
bam-14214	69	16	while	while	SCONJ
bam-14214	69	17	irisin	irisin	ADJ
bam-14214	69	18	injection	injection	NOUN
bam-14214	69	19	showed	show	VERB
bam-14214	69	20	higher	high	ADJ
bam-14214	69	21	expression	expression	NOUN
bam-14214	69	22	than	than	ADP
bam-14214	69	23	endurance	endurance	ADJ
bam-14214	69	24	exercise	exercise	NOUN
bam-14214	69	25	(	(	PUNCT
bam-14214	69	26	p<0.05	p<0.05	NOUN
bam-14214	69	27	)	)	PUNCT
bam-14214	69	28	.	.	PUNCT
bam-14214	70	1	hsp70	hsp70	PROPN
bam-14214	70	2	mrna	mrna	PROPN
bam-14214	70	3	expression	expression	NOUN
bam-14214	70	4	was	be	AUX
bam-14214	70	5	elevated	elevate	VERB
bam-14214	70	6	by	by	ADP
bam-14214	70	7	2.53±0.3	2.53±0.3	PRON
bam-14214	70	8	-	-	NOUN
bam-14214	70	9	fold	fold	VERB
bam-14214	70	10	in	in	ADP
bam-14214	70	11	endurance	endurance	NOUN
bam-14214	70	12	exercise	exercise	NOUN
bam-14214	70	13	,	,	PUNCT
bam-14214	70	14	3.49±0.4	3.49±0.4	ADV
bam-14214	70	15	-	-	ADJ
bam-14214	70	16	fold	fold	ADJ
bam-14214	70	17	in	in	ADP
bam-14214	70	18	resistance	resistance	NOUN
bam-14214	70	19	exercise	exercise	NOUN
bam-14214	70	20	,	,	PUNCT
bam-14214	70	21	and	and	CCONJ
bam-14214	70	22	3.26±0.3	3.26±0.3	ADV
bam-14214	70	23	-	-	NOUN
bam-14214	70	24	fold	fold	VERB
bam-14214	70	25	in	in	ADP
bam-14214	70	26	irisin	irisin	ADJ
bam-14214	70	27	injection	injection	NOUN
bam-14214	70	28	groups	group	NOUN
bam-14214	70	29	,	,	PUNCT
bam-14214	70	30	compared	compare	VERB
bam-14214	70	31	to	to	ADP
bam-14214	70	32	control	control	NOUN
bam-14214	70	33	(	(	PUNCT
bam-14214	70	34	1.0±0.1	1.0±0.1	NUM
bam-14214	70	35	)	)	PUNCT
bam-14214	70	36	.	.	PUNCT
bam-14214	71	1	compared	compare	VERB
bam-14214	71	2	to	to	ADP
bam-14214	71	3	irisin	irisin	VERB
bam-14214	71	4	injection	injection	NOUN
bam-14214	71	5	,	,	PUNCT
bam-14214	71	6	resistance	resistance	NOUN
bam-14214	71	7	exercise	exercise	NOUN
bam-14214	71	8	showed	show	VERB
bam-14214	71	9	no	no	DET
bam-14214	71	10	significant	significant	ADJ
bam-14214	71	11	difference	difference	NOUN
bam-14214	71	12	in	in	ADP
bam-14214	71	13	hsp70	hsp70	NOUN
bam-14214	71	14	expression	expression	NOUN
bam-14214	71	15	(	(	PUNCT
bam-14214	71	16	p>0.05	p>0.05	NOUN
bam-14214	71	17	)	)	PUNCT
bam-14214	71	18	,	,	PUNCT
bam-14214	71	19	while	while	SCONJ
bam-14214	71	20	irisin	irisin	ADJ
bam-14214	71	21	injection	injection	NOUN
bam-14214	71	22	had	have	VERB
bam-14214	71	23	significantly	significantly	ADV
bam-14214	71	24	higher	high	ADJ
bam-14214	71	25	expression	expression	NOUN
bam-14214	71	26	than	than	ADP
bam-14214	71	27	endurance	endurance	ADJ
bam-14214	71	28	exercise	exercise	NOUN
bam-14214	71	29	(	(	PUNCT
bam-14214	71	30	p<0.05	p<0.05	NOUN
bam-14214	71	31	)	)	PUNCT
bam-14214	71	32	.	.	PUNCT
bam-14214	72	1	these	these	DET
bam-14214	72	2	data	datum	NOUN
bam-14214	72	3	are	be	AUX
bam-14214	72	4	presented	present	VERB
bam-14214	72	5	in	in	ADP
bam-14214	72	6	figure	figure	NOUN
bam-14214	72	7	2	2	NUM
bam-14214	72	8	(	(	PUNCT
bam-14214	72	9	panels	panel	NOUN
bam-14214	72	10	e	e	NOUN
bam-14214	72	11	and	and	CCONJ
bam-14214	72	12	f	f	PROPN
bam-14214	72	13	)	)	PUNCT
bam-14214	72	14	.	.	PUNCT
bam-14214	73	1	7	7	NUM
bam-14214	73	2	renal	renal	ADJ
bam-14214	73	3	protein	protein	NOUN
bam-14214	73	4	expression	expression	NOUN
bam-14214	73	5	of	of	ADP
bam-14214	73	6	klotho	klotho	PROPN
bam-14214	73	7	and	and	CCONJ
bam-14214	73	8	hsp70	hsp70	NOUN
bam-14214	73	9	to	to	PART
bam-14214	73	10	confirm	confirm	VERB
bam-14214	73	11	the	the	DET
bam-14214	73	12	qpcr	qpcr	ADJ
bam-14214	73	13	results	result	NOUN
bam-14214	73	14	at	at	ADP
bam-14214	73	15	the	the	DET
bam-14214	73	16	protein	protein	NOUN
bam-14214	73	17	level	level	NOUN
bam-14214	73	18	,	,	PUNCT
bam-14214	73	19	western	western	ADJ
bam-14214	73	20	blot	blot	NOUN
bam-14214	73	21	analysis	analysis	NOUN
bam-14214	73	22	was	be	AUX
bam-14214	73	23	performed	perform	VERB
bam-14214	73	24	on	on	ADP
bam-14214	73	25	kidney	kidney	NOUN
bam-14214	73	26	tissues	tissue	NOUN
bam-14214	73	27	,	,	PUNCT
bam-14214	73	28	with	with	ADP
bam-14214	73	29	gapdh	gapdh	NOUN
bam-14214	73	30	as	as	ADP
bam-14214	73	31	the	the	DET
bam-14214	73	32	loading	loading	NOUN
bam-14214	73	33	control	control	NOUN
bam-14214	73	34	.	.	PUNCT
bam-14214	74	1	densitometric	densitometric	ADJ
bam-14214	74	2	quantification	quantification	NOUN
bam-14214	74	3	(	(	PUNCT
bam-14214	74	4	normalized	normalize	VERB
bam-14214	74	5	to	to	PART
bam-14214	74	6	gapdh	gapdh	VERB
bam-14214	74	7	)	)	PUNCT
bam-14214	74	8	is	be	AUX
bam-14214	74	9	shown	show	VERB
bam-14214	74	10	in	in	ADP
bam-14214	74	11	figure	figure	NOUN
bam-14214	74	12	2	2	NUM
bam-14214	74	13	(	(	PUNCT
bam-14214	74	14	panels	panel	NOUN
bam-14214	74	15	b	b	PROPN
bam-14214	74	16	and	and	CCONJ
bam-14214	74	17	d	d	NOUN
bam-14214	74	18	)	)	PUNCT
bam-14214	74	19	.	.	PUNCT
bam-14214	75	1	all	all	DET
bam-14214	75	2	intervention	intervention	NOUN
bam-14214	75	3	groups	group	NOUN
bam-14214	75	4	showed	show	VERB
bam-14214	75	5	higher	high	ADJ
bam-14214	75	6	klotho	klotho	NOUN
bam-14214	75	7	and	and	CCONJ
bam-14214	75	8	hsp70	hsp70	NOUN
bam-14214	75	9	protein	protein	NOUN
bam-14214	75	10	levels	level	NOUN
bam-14214	75	11	compared	compare	VERB
bam-14214	75	12	to	to	ADP
bam-14214	75	13	control	control	NOUN
bam-14214	75	14	(	(	PUNCT
bam-14214	75	15	p<0.001	p<0.001	PROPN
bam-14214	75	16	)	)	PUNCT
bam-14214	75	17	.	.	PUNCT
bam-14214	76	1	fold	fold	ADJ
bam-14214	76	2	changes	change	NOUN
bam-14214	76	3	relative	relative	ADJ
bam-14214	76	4	to	to	ADP
bam-14214	76	5	control	control	NOUN
bam-14214	76	6	were	be	AUX
bam-14214	76	7	calculated	calculate	VERB
bam-14214	76	8	by	by	ADP
bam-14214	76	9	dividing	divide	VERB
bam-14214	76	10	the	the	DET
bam-14214	76	11	normalized	normalize	VERB
bam-14214	76	12	intensity	intensity	NOUN
bam-14214	76	13	values	value	NOUN
bam-14214	76	14	of	of	ADP
bam-14214	76	15	each	each	DET
bam-14214	76	16	group	group	NOUN
bam-14214	76	17	by	by	ADP
bam-14214	76	18	the	the	DET
bam-14214	76	19	average	average	ADJ
bam-14214	76	20	normalized	normalize	VERB
bam-14214	76	21	intensity	intensity	NOUN
bam-14214	76	22	of	of	ADP
bam-14214	76	23	the	the	DET
bam-14214	76	24	control	control	NOUN
bam-14214	76	25	group	group	NOUN
bam-14214	76	26	.	.	PUNCT
bam-14214	77	1	klotho	klotho	VERB
bam-14214	77	2	protein	protein	NOUN
bam-14214	77	3	expression	expression	NOUN
bam-14214	77	4	increased	increase	VERB
bam-14214	77	5	by	by	ADP
bam-14214	77	6	1.50	1.50	NUM
bam-14214	77	7	-	-	NOUN
bam-14214	77	8	fold	fold	ADJ
bam-14214	77	9	in	in	ADP
bam-14214	77	10	the	the	DET
bam-14214	77	11	endurance	endurance	NOUN
bam-14214	77	12	exercise	exercise	NOUN
bam-14214	77	13	group	group	NOUN
bam-14214	77	14	,	,	PUNCT
bam-14214	77	15	3.48	3.48	NUM
bam-14214	77	16	-	-	NOUN
bam-14214	77	17	fold	fold	VERB
bam-14214	77	18	in	in	ADP
bam-14214	77	19	the	the	DET
bam-14214	77	20	resistance	resistance	NOUN
bam-14214	77	21	exercise	exercise	NOUN
bam-14214	77	22	group	group	NOUN
bam-14214	77	23	,	,	PUNCT
bam-14214	77	24	and	and	CCONJ
bam-14214	77	25	3.12	3.12	NUM
bam-14214	77	26	-	-	ADJ
bam-14214	77	27	fold	fold	ADJ
bam-14214	77	28	in	in	ADP
bam-14214	77	29	the	the	DET
bam-14214	77	30	irisin	irisin	NOUN
bam-14214	77	31	injection	injection	NOUN
bam-14214	77	32	group	group	NOUN
bam-14214	77	33	,	,	PUNCT
bam-14214	77	34	relative	relative	ADJ
bam-14214	77	35	to	to	ADP
bam-14214	77	36	control	control	NOUN
bam-14214	77	37	.	.	PUNCT
bam-14214	78	1	compared	compare	VERB
bam-14214	78	2	to	to	ADP
bam-14214	78	3	irisin	irisin	VERB
bam-14214	78	4	injection	injection	NOUN
bam-14214	78	5	,	,	PUNCT
bam-14214	78	6	resistance	resistance	NOUN
bam-14214	78	7	exercise	exercise	NOUN
bam-14214	78	8	showed	show	VERB
bam-14214	78	9	no	no	DET
bam-14214	78	10	significant	significant	ADJ
bam-14214	78	11	difference	difference	NOUN
bam-14214	78	12	in	in	ADP
bam-14214	78	13	klotho	klotho	ADJ
bam-14214	78	14	expression	expression	NOUN
bam-14214	78	15	(	(	PUNCT
bam-14214	78	16	p>0.05	p>0.05	PROPN
bam-14214	78	17	)	)	PUNCT
bam-14214	78	18	,	,	PUNCT
bam-14214	78	19	while	while	SCONJ
bam-14214	78	20	irisin	irisin	ADJ
bam-14214	78	21	injection	injection	NOUN
bam-14214	78	22	significantly	significantly	ADV
bam-14214	78	23	increased	increase	VERB
bam-14214	78	24	expression	expression	NOUN
bam-14214	78	25	compared	compare	VERB
bam-14214	78	26	to	to	ADP
bam-14214	78	27	endurance	endurance	ADJ
bam-14214	78	28	exercise	exercise	NOUN
bam-14214	78	29	(	(	PUNCT
bam-14214	78	30	p<0.001	p<0.001	PROPN
bam-14214	78	31	)	)	PUNCT
bam-14214	78	32	.	.	PUNCT
bam-14214	79	1	hsp70	hsp70	NOUN
bam-14214	79	2	protein	protein	NOUN
bam-14214	79	3	expression	expression	NOUN
bam-14214	79	4	was	be	AUX
bam-14214	79	5	elevated	elevate	VERB
bam-14214	79	6	by	by	ADP
bam-14214	79	7	1.30	1.30	NUM
bam-14214	79	8	-	-	NOUN
bam-14214	79	9	fold	fold	ADJ
bam-14214	79	10	in	in	ADP
bam-14214	79	11	endurance	endurance	NOUN
bam-14214	79	12	exercise	exercise	NOUN
bam-14214	79	13	,	,	PUNCT
bam-14214	79	14	2.80	2.80	NUM
bam-14214	79	15	-	-	NOUN
bam-14214	79	16	fold	fold	VERB
bam-14214	79	17	in	in	ADV
bam-14214	79	18	resistance	resistance	NOUN
bam-14214	79	19	exercise	exercise	NOUN
bam-14214	79	20	,	,	PUNCT
bam-14214	79	21	and	and	CCONJ
bam-14214	79	22	2.48	2.48	NUM
bam-14214	79	23	-	-	NOUN
bam-14214	79	24	fold	fold	VERB
bam-14214	79	25	in	in	ADP
bam-14214	79	26	irisin	irisin	ADJ
bam-14214	79	27	injection	injection	NOUN
bam-14214	79	28	groups	group	NOUN
bam-14214	79	29	,	,	PUNCT
bam-14214	79	30	relative	relative	ADJ
bam-14214	79	31	to	to	ADP
bam-14214	79	32	control	control	NOUN
bam-14214	79	33	.	.	PUNCT
bam-14214	80	1	compared	compare	VERB
bam-14214	80	2	to	to	ADP
bam-14214	80	3	irisin	irisin	VERB
bam-14214	80	4	injection	injection	NOUN
bam-14214	80	5	,	,	PUNCT
bam-14214	80	6	resistance	resistance	NOUN
bam-14214	80	7	exercise	exercise	NOUN
bam-14214	80	8	showed	show	VERB
bam-14214	80	9	no	no	DET
bam-14214	80	10	significant	significant	ADJ
bam-14214	80	11	difference	difference	NOUN
bam-14214	80	12	in	in	ADP
bam-14214	80	13	hsp70	hsp70	NOUN
bam-14214	80	14	expression	expression	NOUN
bam-14214	80	15	(	(	PUNCT
bam-14214	80	16	p>0.05	p>0.05	NOUN
bam-14214	80	17	)	)	PUNCT
bam-14214	80	18	,	,	PUNCT
bam-14214	80	19	while	while	SCONJ
bam-14214	80	20	irisin	irisin	ADJ
bam-14214	80	21	injection	injection	NOUN
bam-14214	80	22	significantly	significantly	ADV
bam-14214	80	23	increased	increase	VERB
bam-14214	80	24	expression	expression	NOUN
bam-14214	80	25	compared	compare	VERB
bam-14214	80	26	to	to	ADP
bam-14214	80	27	endurance	endurance	ADJ
bam-14214	80	28	exercise	exercise	NOUN
bam-14214	80	29	(	(	PUNCT
bam-14214	80	30	p<0.001	p<0.001	PROPN
bam-14214	80	31	)	)	PUNCT
bam-14214	80	32	.	.	PUNCT
bam-14214	81	1	statistical	statistical	ADJ
bam-14214	81	2	analysis	analysis	NOUN
bam-14214	81	3	of	of	ADP
bam-14214	81	4	correlations	correlation	NOUN
bam-14214	81	5	correlation	correlation	NOUN
bam-14214	81	6	analyses	analysis	NOUN
bam-14214	81	7	between	between	ADP
bam-14214	81	8	plasma	plasma	NOUN
bam-14214	81	9	irisin	irisin	NOUN
bam-14214	81	10	levels	level	NOUN
bam-14214	81	11	(	(	PUNCT
bam-14214	81	12	ng	ng	NOUN
bam-14214	81	13	/	/	SYM
bam-14214	81	14	ml	ml	PROPN
bam-14214	81	15	)	)	PUNCT
bam-14214	81	16	and	and	CCONJ
bam-14214	81	17	relative	relative	ADJ
bam-14214	81	18	mrna	mrna	PROPN
bam-14214	81	19	expression	expression	NOUN
bam-14214	81	20	of	of	ADP
bam-14214	81	21	klotho	klotho	PROPN
bam-14214	81	22	and	and	CCONJ
bam-14214	81	23	hsp70	hsp70	PROPN
bam-14214	81	24	(	(	PUNCT
bam-14214	81	25	measured	measure	VERB
bam-14214	81	26	by	by	ADP
bam-14214	81	27	real	real	ADJ
bam-14214	81	28	-	-	PUNCT
bam-14214	81	29	time	time	NOUN
bam-14214	81	30	pcr	pcr	NOUN
bam-14214	81	31	and	and	CCONJ
bam-14214	81	32	normalized	normalize	VERB
bam-14214	81	33	to	to	PART
bam-14214	81	34	gapdh	gapdh	VERB
bam-14214	81	35	)	)	PUNCT
bam-14214	81	36	are	be	AUX
bam-14214	81	37	presented	present	VERB
bam-14214	81	38	in	in	ADP
bam-14214	81	39	figure	figure	NOUN
bam-14214	81	40	3	3	NUM
bam-14214	81	41	.	.	PUNCT
bam-14214	81	42	plasma	plasma	NOUN
bam-14214	81	43	irisin	irisin	PROPN
bam-14214	81	44	levels	level	NOUN
bam-14214	81	45	showed	show	VERB
bam-14214	81	46	a	a	DET
bam-14214	81	47	strong	strong	ADJ
bam-14214	81	48	positive	positive	ADJ
bam-14214	81	49	correlation	correlation	NOUN
bam-14214	81	50	with	with	ADP
bam-14214	81	51	klotho	klotho	VERB
bam-14214	81	52	expression	expression	NOUN
bam-14214	81	53	(	(	PUNCT
bam-14214	81	54	r=	r=	ADJ
bam-14214	81	55	0.9498	0.9498	NUM
bam-14214	81	56	,	,	PUNCT
bam-14214	81	57	p<0.0001	p<0.0001	NOUN
bam-14214	81	58	)	)	PUNCT
bam-14214	81	59	and	and	CCONJ
bam-14214	81	60	a	a	DET
bam-14214	81	61	moderate	moderate	ADJ
bam-14214	81	62	positive	positive	ADJ
bam-14214	81	63	correlation	correlation	NOUN
bam-14214	81	64	with	with	ADP
bam-14214	81	65	hsp70	hsp70	NOUN
bam-14214	81	66	expression	expression	NOUN
bam-14214	81	67	(	(	PUNCT
bam-14214	81	68	r=	r=	ADJ
bam-14214	81	69	0.7511	0.7511	NUM
bam-14214	81	70	,	,	PUNCT
bam-14214	81	71	p<0.003	p<0.003	NOUN
bam-14214	81	72	)	)	PUNCT
bam-14214	81	73	,	,	PUNCT
bam-14214	81	74	as	as	SCONJ
bam-14214	81	75	determined	determine	VERB
bam-14214	81	76	by	by	ADP
bam-14214	81	77	a	a	DET
bam-14214	81	78	two	two	NUM
bam-14214	81	79	-	-	PUNCT
bam-14214	81	80	tailed	tail	VERB
bam-14214	81	81	pearson	pearson	NOUN
bam-14214	81	82	correlation	correlation	NOUN
bam-14214	81	83	test	test	NOUN
bam-14214	81	84	.	.	PUNCT
bam-14214	82	1	survival	survival	NOUN
bam-14214	82	2	analysis	analysis	NOUN
bam-14214	82	3	a	a	DET
bam-14214	82	4	20	20	NUM
bam-14214	82	5	-	-	PUNCT
bam-14214	82	6	month	month	NOUN
bam-14214	82	7	kaplan	kaplan	PROPN
bam-14214	82	8	–	–	PUNCT
bam-14214	82	9	meier	meier	PROPN
bam-14214	82	10	survival	survival	NOUN
bam-14214	82	11	analysis	analysis	NOUN
bam-14214	82	12	was	be	AUX
bam-14214	82	13	conducted	conduct	VERB
bam-14214	82	14	to	to	PART
bam-14214	82	15	evaluate	evaluate	VERB
bam-14214	82	16	the	the	DET
bam-14214	82	17	long	long	ADJ
bam-14214	82	18	-	-	PUNCT
bam-14214	82	19	term	term	NOUN
bam-14214	82	20	effects	effect	NOUN
bam-14214	82	21	of	of	ADP
bam-14214	82	22	resistance	resistance	NOUN
bam-14214	82	23	training	training	NOUN
bam-14214	82	24	,	,	PUNCT
bam-14214	82	25	endurance	endurance	NOUN
bam-14214	82	26	training	training	NOUN
bam-14214	82	27	,	,	PUNCT
bam-14214	82	28	and	and	CCONJ
bam-14214	82	29	irisin	irisin	VERB
bam-14214	82	30	administration	administration	NOUN
bam-14214	82	31	on	on	ADP
bam-14214	82	32	mortality	mortality	NOUN
bam-14214	82	33	in	in	ADP
bam-14214	82	34	nmri	nmri	ADJ
bam-14214	82	35	mice	mouse	NOUN
bam-14214	82	36	(	(	PUNCT
bam-14214	82	37	figure	figure	NOUN
bam-14214	82	38	4	4	NUM
bam-14214	82	39	)	)	PUNCT
bam-14214	82	40	.	.	PUNCT
bam-14214	83	1	over	over	ADP
bam-14214	83	2	the	the	DET
bam-14214	83	3	follow	follow	NOUN
bam-14214	83	4	-	-	PUNCT
bam-14214	83	5	up	up	NOUN
bam-14214	83	6	period	period	NOUN
bam-14214	83	7	,	,	PUNCT
bam-14214	83	8	the	the	DET
bam-14214	83	9	control	control	NOUN
bam-14214	83	10	group	group	NOUN
bam-14214	83	11	exhibited	exhibit	VERB
bam-14214	83	12	the	the	DET
bam-14214	83	13	highest	high	ADJ
bam-14214	83	14	number	number	NOUN
bam-14214	83	15	of	of	ADP
bam-14214	83	16	deaths	death	NOUN
bam-14214	83	17	(	(	PUNCT
bam-14214	83	18	n=8	n=8	NUM
bam-14214	83	19	)	)	PUNCT
bam-14214	83	20	,	,	PUNCT
bam-14214	83	21	whereas	whereas	SCONJ
bam-14214	83	22	the	the	DET
bam-14214	83	23	resistance	resistance	NOUN
bam-14214	83	24	exercise	exercise	NOUN
bam-14214	83	25	group	group	NOUN
bam-14214	83	26	showed	show	VERB
bam-14214	83	27	the	the	DET
bam-14214	83	28	lowest	low	ADJ
bam-14214	83	29	mortality	mortality	NOUN
bam-14214	83	30	(	(	PUNCT
bam-14214	83	31	n=3	n=3	NOUN
bam-14214	83	32	)	)	PUNCT
bam-14214	83	33	.	.	PUNCT
bam-14214	84	1	the	the	DET
bam-14214	84	2	endurance	endurance	NOUN
bam-14214	84	3	exercise	exercise	NOUN
bam-14214	84	4	and	and	CCONJ
bam-14214	84	5	irisin	irisin	VERB
bam-14214	84	6	injection	injection	NOUN
bam-14214	84	7	groups	group	NOUN
bam-14214	84	8	experienced	experience	VERB
bam-14214	84	9	5	5	NUM
bam-14214	84	10	and	and	CCONJ
bam-14214	84	11	4	4	NUM
bam-14214	84	12	deaths	death	NOUN
bam-14214	84	13	,	,	PUNCT
bam-14214	84	14	respectively	respectively	ADV
bam-14214	84	15	.	.	PUNCT
bam-14214	85	1	median	median	ADJ
bam-14214	85	2	survival	survival	NOUN
bam-14214	85	3	time	time	NOUN
bam-14214	85	4	was	be	AUX
bam-14214	85	5	480	480	NUM
bam-14214	85	6	days	day	NOUN
bam-14214	85	7	in	in	ADP
bam-14214	85	8	the	the	DET
bam-14214	85	9	control	control	NOUN
bam-14214	85	10	group	group	NOUN
bam-14214	85	11	,	,	PUNCT
bam-14214	85	12	while	while	SCONJ
bam-14214	85	13	it	it	PRON
bam-14214	85	14	was	be	AUX
bam-14214	85	15	not	not	PART
bam-14214	85	16	reached	reach	VERB
bam-14214	85	17	in	in	ADP
bam-14214	85	18	any	any	PRON
bam-14214	85	19	of	of	ADP
bam-14214	85	20	the	the	DET
bam-14214	85	21	intervention	intervention	NOUN
bam-14214	85	22	groups	group	NOUN
bam-14214	85	23	.	.	PUNCT
bam-14214	86	1	although	although	SCONJ
bam-14214	86	2	the	the	DET
bam-14214	86	3	log	log	NOUN
bam-14214	86	4	-	-	PUNCT
bam-14214	86	5	rank	rank	NOUN
bam-14214	86	6	(	(	PUNCT
bam-14214	86	7	mantel	mantel	NOUN
bam-14214	86	8	–	–	PUNCT
bam-14214	86	9	cox	cox	NOUN
bam-14214	86	10	)	)	PUNCT
bam-14214	86	11	test	test	NOUN
bam-14214	86	12	did	do	AUX
bam-14214	86	13	not	not	PART
bam-14214	86	14	reveal	reveal	VERB
bam-14214	86	15	a	a	DET
bam-14214	86	16	statistically	statistically	ADV
bam-14214	86	17	significant	significant	ADJ
bam-14214	86	18	difference	difference	NOUN
bam-14214	86	19	among	among	ADP
bam-14214	86	20	groups	group	NOUN
bam-14214	86	21	(	(	PUNCT
bam-14214	86	22	χ²	χ²	NOUN
bam-14214	86	23	=	=	SYM
bam-14214	86	24	6.425	6.425	NUM
bam-14214	86	25	,	,	PUNCT
bam-14214	86	26	df	df	PROPN
bam-14214	86	27	=	=	SYM
bam-14214	86	28	3	3	NUM
bam-14214	86	29	,	,	PUNCT
bam-14214	86	30	p=0.0927	p=0.0927	NUM
bam-14214	86	31	)	)	PUNCT
bam-14214	86	32	,	,	PUNCT
bam-14214	86	33	the	the	DET
bam-14214	86	34	log	log	NOUN
bam-14214	86	35	-	-	PUNCT
bam-14214	86	36	rank	rank	NOUN
bam-14214	86	37	test	test	NOUN
bam-14214	86	38	for	for	ADP
bam-14214	86	39	trend	trend	NOUN
bam-14214	86	40	indicated	indicate	VERB
bam-14214	86	41	a	a	DET
bam-14214	86	42	significant	significant	ADJ
bam-14214	86	43	linear	linear	ADJ
bam-14214	86	44	trend	trend	NOUN
bam-14214	86	45	toward	toward	ADP
bam-14214	86	46	improved	improved	ADJ
bam-14214	86	47	survival	survival	NOUN
bam-14214	86	48	across	across	ADP
bam-14214	86	49	the	the	DET
bam-14214	86	50	intervention	intervention	NOUN
bam-14214	86	51	groups	group	NOUN
bam-14214	86	52	(	(	PUNCT
bam-14214	86	53	χ²	χ²	NOUN
bam-14214	86	54	=	=	SYM
bam-14214	86	55	4.125	4.125	NUM
bam-14214	86	56	,	,	PUNCT
bam-14214	86	57	p=0.0423	p=0.0423	NOUN
bam-14214	86	58	)	)	PUNCT
bam-14214	86	59	.	.	PUNCT
bam-14214	87	1	this	this	PRON
bam-14214	87	2	suggests	suggest	VERB
bam-14214	87	3	that	that	SCONJ
bam-14214	87	4	early8	early8	NOUN
bam-14214	87	5	life	life	NOUN
bam-14214	87	6	interventions	intervention	NOUN
bam-14214	87	7	,	,	PUNCT
bam-14214	87	8	particularly	particularly	ADV
bam-14214	87	9	resistance	resistance	NOUN
bam-14214	87	10	training	training	NOUN
bam-14214	87	11	and	and	CCONJ
bam-14214	87	12	irisin	irisin	PROPN
bam-14214	87	13	administration	administration	NOUN
bam-14214	87	14	,	,	PUNCT
bam-14214	87	15	may	may	AUX
bam-14214	87	16	contribute	contribute	VERB
bam-14214	87	17	to	to	ADP
bam-14214	87	18	enhanced	enhanced	ADJ
bam-14214	87	19	long	long	ADJ
bam-14214	87	20	-	-	PUNCT
bam-14214	87	21	term	term	NOUN
bam-14214	87	22	survival	survival	NOUN
bam-14214	87	23	.	.	PUNCT
bam-14214	88	1	these	these	DET
bam-14214	88	2	findings	finding	NOUN
bam-14214	88	3	,	,	PUNCT
bam-14214	88	4	although	although	SCONJ
bam-14214	88	5	preliminary	preliminary	ADJ
bam-14214	88	6	and	and	CCONJ
bam-14214	88	7	derived	derive	VERB
bam-14214	88	8	from	from	ADP
bam-14214	88	9	healthy	healthy	ADJ
bam-14214	88	10	young	young	ADJ
bam-14214	88	11	mice	mouse	NOUN
bam-14214	88	12	,	,	PUNCT
bam-14214	88	13	support	support	VERB
bam-14214	88	14	the	the	DET
bam-14214	88	15	hypothesis	hypothesis	NOUN
bam-14214	88	16	that	that	PRON
bam-14214	88	17	short	short	ADJ
bam-14214	88	18	-	-	PUNCT
bam-14214	88	19	term	term	NOUN
bam-14214	88	20	early	early	ADJ
bam-14214	88	21	interventions	intervention	NOUN
bam-14214	88	22	can	can	AUX
bam-14214	88	23	exert	exert	VERB
bam-14214	88	24	lasting	lasting	ADJ
bam-14214	88	25	effects	effect	NOUN
bam-14214	88	26	on	on	ADP
bam-14214	88	27	physiological	physiological	ADJ
bam-14214	88	28	resilience	resilience	NOUN
bam-14214	88	29	.	.	PUNCT
bam-14214	89	1	however	however	ADV
bam-14214	89	2	,	,	PUNCT
bam-14214	89	3	further	further	ADJ
bam-14214	89	4	studies	study	NOUN
bam-14214	89	5	using	use	VERB
bam-14214	89	6	aged	aged	ADJ
bam-14214	89	7	or	or	CCONJ
bam-14214	89	8	disease	disease	NOUN
bam-14214	89	9	-	-	PUNCT
bam-14214	89	10	prone	prone	ADJ
bam-14214	89	11	models	model	NOUN
bam-14214	89	12	and	and	CCONJ
bam-14214	89	13	extended	extended	ADJ
bam-14214	89	14	follow	follow	NOUN
bam-14214	89	15	-	-	PUNCT
bam-14214	89	16	up	up	NOUN
bam-14214	89	17	are	be	AUX
bam-14214	89	18	needed	need	VERB
bam-14214	89	19	to	to	PART
bam-14214	89	20	validate	validate	VERB
bam-14214	89	21	these	these	DET
bam-14214	89	22	effects	effect	NOUN
bam-14214	89	23	and	and	CCONJ
bam-14214	89	24	determine	determine	VERB
bam-14214	89	25	their	their	PRON
bam-14214	89	26	relevance	relevance	NOUN
bam-14214	89	27	to	to	ADP
bam-14214	89	28	aging	age	VERB
bam-14214	89	29	-	-	PUNCT
bam-14214	89	30	related	relate	VERB
bam-14214	89	31	mortality	mortality	NOUN
bam-14214	89	32	.	.	PUNCT
bam-14214	90	1	discussion	discussion	NOUN
bam-14214	90	2	this	this	DET
bam-14214	90	3	study	study	NOUN
bam-14214	90	4	investigated	investigate	VERB
bam-14214	90	5	the	the	DET
bam-14214	90	6	effects	effect	NOUN
bam-14214	90	7	of	of	ADP
bam-14214	90	8	resistance	resistance	NOUN
bam-14214	90	9	training	training	NOUN
bam-14214	90	10	,	,	PUNCT
bam-14214	90	11	endurance	endurance	NOUN
bam-14214	90	12	training	training	NOUN
bam-14214	90	13	,	,	PUNCT
bam-14214	90	14	and	and	CCONJ
bam-14214	90	15	exogenous	exogenous	ADJ
bam-14214	90	16	irisin	irisin	ADJ
bam-14214	90	17	administration	administration	NOUN
bam-14214	90	18	on	on	ADP
bam-14214	90	19	plasma	plasma	NOUN
bam-14214	90	20	irisin	irisin	PROPN
bam-14214	90	21	levels	level	NOUN
bam-14214	90	22	,	,	PUNCT
bam-14214	90	23	the	the	DET
bam-14214	90	24	expression	expression	NOUN
bam-14214	90	25	of	of	ADP
bam-14214	90	26	klotho	klotho	PROPN
bam-14214	90	27	and	and	CCONJ
bam-14214	90	28	hsp70	hsp70	NOUN
bam-14214	90	29	(	(	PUNCT
bam-14214	90	30	at	at	ADP
bam-14214	90	31	both	both	CCONJ
bam-14214	90	32	mrna	mrna	NOUN
bam-14214	90	33	and	and	CCONJ
bam-14214	90	34	protein	protein	NOUN
bam-14214	90	35	levels	level	NOUN
bam-14214	90	36	)	)	PUNCT
bam-14214	90	37	in	in	ADP
bam-14214	90	38	renal	renal	ADJ
bam-14214	90	39	tissue	tissue	NOUN
bam-14214	90	40	,	,	PUNCT
bam-14214	90	41	and	and	CCONJ
bam-14214	90	42	long	long	ADJ
bam-14214	90	43	-	-	PUNCT
bam-14214	90	44	term	term	NOUN
bam-14214	90	45	survival	survival	NOUN
bam-14214	90	46	in	in	ADP
bam-14214	90	47	nmri	nmri	ADJ
bam-14214	90	48	mice	mouse	NOUN
bam-14214	90	49	.	.	PUNCT
bam-14214	91	1	while	while	SCONJ
bam-14214	91	2	the	the	DET
bam-14214	91	3	study	study	NOUN
bam-14214	91	4	employed	employ	VERB
bam-14214	91	5	young	young	ADJ
bam-14214	91	6	mice	mouse	NOUN
bam-14214	91	7	as	as	ADP
bam-14214	91	8	a	a	DET
bam-14214	91	9	preventive	preventive	ADJ
bam-14214	91	10	model	model	NOUN
bam-14214	91	11	to	to	PART
bam-14214	91	12	simulate	simulate	VERB
bam-14214	91	13	early	early	ADJ
bam-14214	91	14	-	-	PUNCT
bam-14214	91	15	life	life	NOUN
bam-14214	91	16	interventions	intervention	NOUN
bam-14214	91	17	,	,	PUNCT
bam-14214	91	18	our	our	PRON
bam-14214	91	19	findings	finding	NOUN
bam-14214	91	20	demonstrate	demonstrate	VERB
bam-14214	91	21	that	that	SCONJ
bam-14214	91	22	all	all	DET
bam-14214	91	23	interventions	intervention	NOUN
bam-14214	91	24	significantly	significantly	ADV
bam-14214	91	25	increased	increase	VERB
bam-14214	91	26	plasma	plasma	NOUN
bam-14214	91	27	irisin	irisin	NOUN
bam-14214	91	28	concentrations	concentration	NOUN
bam-14214	91	29	,	,	PUNCT
bam-14214	91	30	upregulated	upregulate	VERB
bam-14214	91	31	klotho	klotho	NOUN
bam-14214	91	32	and	and	CCONJ
bam-14214	91	33	hsp70	hsp70	NOUN
bam-14214	91	34	expression	expression	NOUN
bam-14214	91	35	,	,	PUNCT
bam-14214	91	36	and	and	CCONJ
bam-14214	91	37	improved	improved	ADJ
bam-14214	91	38	survival	survival	NOUN
bam-14214	91	39	rates	rate	NOUN
bam-14214	91	40	compared	compare	VERB
bam-14214	91	41	to	to	ADP
bam-14214	91	42	the	the	DET
bam-14214	91	43	control	control	NOUN
bam-14214	91	44	group	group	NOUN
bam-14214	91	45	,	,	PUNCT
bam-14214	91	46	highlighting	highlight	VERB
bam-14214	91	47	their	their	PRON
bam-14214	91	48	potential	potential	NOUN
bam-14214	91	49	to	to	PART
bam-14214	91	50	enhance	enhance	VERB
bam-14214	91	51	cellular	cellular	ADJ
bam-14214	91	52	resilience	resilience	NOUN
bam-14214	91	53	and	and	CCONJ
bam-14214	91	54	systemic	systemic	ADJ
bam-14214	91	55	health	health	NOUN
bam-14214	91	56	.	.	PUNCT
bam-14214	92	1	these	these	PRON
bam-14214	92	2	results	result	VERB
bam-14214	92	3	position	position	NOUN
bam-14214	92	4	irisin	irisin	NOUN
bam-14214	92	5	as	as	ADP
bam-14214	92	6	a	a	DET
bam-14214	92	7	promising	promising	ADJ
bam-14214	92	8	exercise	exercise	NOUN
bam-14214	92	9	-	-	PUNCT
bam-14214	92	10	mimetic	mimetic	ADJ
bam-14214	92	11	agent	agent	NOUN
bam-14214	92	12	,	,	PUNCT
bam-14214	92	13	particularly	particularly	ADV
bam-14214	92	14	for	for	ADP
bam-14214	92	15	individuals	individual	NOUN
bam-14214	92	16	with	with	ADP
bam-14214	92	17	limited	limited	ADJ
bam-14214	92	18	mobility	mobility	NOUN
bam-14214	92	19	such	such	ADJ
bam-14214	92	20	as	as	ADP
bam-14214	92	21	the	the	DET
bam-14214	92	22	elderly	elderly	ADJ
bam-14214	92	23	,	,	PUNCT
bam-14214	92	24	post	post	ADJ
bam-14214	92	25	-	-	ADJ
bam-14214	92	26	surgical	surgical	ADJ
bam-14214	92	27	patients	patient	NOUN
bam-14214	92	28	,	,	PUNCT
bam-14214	92	29	or	or	CCONJ
bam-14214	92	30	those	those	PRON
bam-14214	92	31	with	with	ADP
bam-14214	92	32	severe	severe	ADJ
bam-14214	92	33	neuromuscular	neuromuscular	ADJ
bam-14214	92	34	or	or	CCONJ
bam-14214	92	35	orthopedic	orthopedic	ADJ
bam-14214	92	36	impairments	impairment	NOUN
bam-14214	92	37	.	.	PUNCT
bam-14214	93	1	physical	physical	ADJ
bam-14214	93	2	exercise	exercise	NOUN
bam-14214	93	3	is	be	AUX
bam-14214	93	4	widely	widely	ADV
bam-14214	93	5	recognized	recognize	VERB
bam-14214	93	6	as	as	ADP
bam-14214	93	7	a	a	DET
bam-14214	93	8	potent	potent	ADJ
bam-14214	93	9	intervention	intervention	NOUN
bam-14214	93	10	for	for	ADP
bam-14214	93	11	promoting	promote	VERB
bam-14214	93	12	health	health	NOUN
bam-14214	93	13	and	and	CCONJ
bam-14214	93	14	mitigating	mitigate	VERB
bam-14214	93	15	cellular	cellular	ADJ
bam-14214	93	16	stress	stress	NOUN
bam-14214	93	17	,	,	PUNCT
bam-14214	93	18	largely	largely	ADV
bam-14214	93	19	through	through	ADP
bam-14214	93	20	the	the	DET
bam-14214	93	21	upregulation	upregulation	NOUN
bam-14214	93	22	of	of	ADP
bam-14214	93	23	protective	protective	ADJ
bam-14214	93	24	factors	factor	NOUN
bam-14214	93	25	like	like	ADP
bam-14214	93	26	klotho	klotho	NOUN
bam-14214	93	27	and	and	CCONJ
bam-14214	93	28	hsp70	hsp70	NOUN
bam-14214	93	29	,	,	PUNCT
bam-14214	93	30	which	which	PRON
bam-14214	93	31	are	be	AUX
bam-14214	93	32	implicated	implicate	VERB
bam-14214	93	33	in	in	ADP
bam-14214	93	34	cellular	cellular	ADJ
bam-14214	93	35	resilience	resilience	NOUN
bam-14214	93	36	and	and	CCONJ
bam-14214	93	37	longevity.14	longevity.14	PROPN
bam-14214	93	38	previous	previous	ADJ
bam-14214	93	39	studies	study	NOUN
bam-14214	93	40	have	have	AUX
bam-14214	93	41	consistently	consistently	ADV
bam-14214	93	42	shown	show	VERB
bam-14214	93	43	that	that	SCONJ
bam-14214	93	44	exercise	exercise	NOUN
bam-14214	93	45	enhances	enhance	VERB
bam-14214	93	46	the	the	DET
bam-14214	93	47	expression	expression	NOUN
bam-14214	93	48	of	of	ADP
bam-14214	93	49	these	these	DET
bam-14214	93	50	genes	gene	NOUN
bam-14214	93	51	across	across	ADP
bam-14214	93	52	various	various	ADJ
bam-14214	93	53	models	model	NOUN
bam-14214	93	54	.	.	PUNCT
bam-14214	94	1	for	for	ADP
bam-14214	94	2	instance	instance	NOUN
bam-14214	94	3	,	,	PUNCT
bam-14214	94	4	mostafidi	mostafidi	PROPN
bam-14214	94	5	et	et	PROPN
bam-14214	94	6	al	al	PROPN
bam-14214	94	7	.	.	PROPN
bam-14214	94	8	reported	report	VERB
bam-14214	94	9	that	that	SCONJ
bam-14214	94	10	regular	regular	ADJ
bam-14214	94	11	aerobic	aerobic	ADJ
bam-14214	94	12	exercise	exercise	NOUN
bam-14214	94	13	increased	increase	VERB
bam-14214	94	14	plasma	plasma	NOUN
bam-14214	94	15	klotho	klotho	PROPN
bam-14214	94	16	levels	level	NOUN
bam-14214	94	17	via	via	ADP
bam-14214	94	18	pgc-1α	pgc-1α	NOUN
bam-14214	94	19	activation	activation	NOUN
bam-14214	94	20	in	in	ADP
bam-14214	94	21	humans,15	humans,15	NOUN
bam-14214	94	22	while	while	SCONJ
bam-14214	94	23	ji	ji	PROPN
bam-14214	94	24	et	et	PROPN
bam-14214	94	25	al	al	PROPN
bam-14214	94	26	.	.	PROPN
bam-14214	94	27	found	find	VERB
bam-14214	94	28	that	that	SCONJ
bam-14214	94	29	both	both	CCONJ
bam-14214	94	30	intermittent	intermittent	ADJ
bam-14214	94	31	and	and	CCONJ
bam-14214	94	32	continuous	continuous	ADJ
bam-14214	94	33	aerobic	aerobic	ADJ
bam-14214	94	34	exercise	exercise	NOUN
bam-14214	94	35	in	in	ADP
bam-14214	94	36	sprague	sprague	PROPN
bam-14214	94	37	dawley	dawley	NOUN
bam-14214	94	38	rats	rat	NOUN
bam-14214	94	39	significantly	significantly	ADV
bam-14214	94	40	elevated	elevate	VERB
bam-14214	94	41	klotho	klotho	PROPN
bam-14214	94	42	mrna	mrna	PROPN
bam-14214	94	43	and	and	CCONJ
bam-14214	94	44	protein	protein	NOUN
bam-14214	94	45	levels	level	NOUN
bam-14214	94	46	,	,	PUNCT
bam-14214	94	47	reduced	reduce	VERB
bam-14214	94	48	reactive	reactive	ADJ
bam-14214	94	49	oxygen	oxygen	NOUN
bam-14214	94	50	species	specie	NOUN
bam-14214	94	51	(	(	PUNCT
bam-14214	94	52	ros	ros	PROPN
bam-14214	94	53	)	)	PUNCT
bam-14214	94	54	,	,	PUNCT
bam-14214	94	55	and	and	CCONJ
bam-14214	94	56	improved	improved	ADJ
bam-14214	94	57	survival	survival	NOUN
bam-14214	94	58	,	,	PUNCT
bam-14214	94	59	suggesting	suggest	VERB
bam-14214	94	60	a	a	DET
bam-14214	94	61	role	role	NOUN
bam-14214	94	62	for	for	ADP
bam-14214	94	63	klotho	klotho	NOUN
bam-14214	94	64	in	in	ADP
bam-14214	94	65	exercise	exercise	NOUN
bam-14214	94	66	-	-	PUNCT
bam-14214	94	67	mediated	mediate	VERB
bam-14214	94	68	longevity.16	longevity.16	NOUN
bam-14214	94	69	more	more	ADV
bam-14214	94	70	recently	recently	ADV
bam-14214	94	71	,	,	PUNCT
bam-14214	94	72	a	a	DET
bam-14214	94	73	2024	2024	NUM
bam-14214	94	74	study	study	NOUN
bam-14214	94	75	demonstrated	demonstrate	VERB
bam-14214	94	76	that	that	SCONJ
bam-14214	94	77	8	8	NUM
bam-14214	94	78	weeks	week	NOUN
bam-14214	94	79	of	of	ADP
bam-14214	94	80	endurance	endurance	NOUN
bam-14214	94	81	and	and	CCONJ
bam-14214	94	82	resistance	resistance	NOUN
bam-14214	94	83	exercise	exercise	NOUN
bam-14214	94	84	increased	increase	VERB
bam-14214	94	85	serum	serum	NOUN
bam-14214	94	86	fgf23	fgf23	PROPN
bam-14214	94	87	and	and	CCONJ
bam-14214	94	88	soluble	soluble	ADJ
bam-14214	94	89	klotho	klotho	VERB
bam-14214	94	90	levels	level	NOUN
bam-14214	94	91	,	,	PUNCT
bam-14214	94	92	improving	improve	VERB
bam-14214	94	93	glucose	glucose	NOUN
bam-14214	94	94	metabolism	metabolism	NOUN
bam-14214	94	95	in	in	ADP
bam-14214	94	96	type	type	NOUN
bam-14214	94	97	2	2	NUM
bam-14214	94	98	diabetic	diabetic	NOUN
bam-14214	94	99	women.17	women.17	NOUN
bam-14214	94	100	additionally	additionally	ADV
bam-14214	94	101	,	,	PUNCT
bam-14214	94	102	shamsi	shamsi	PROPN
bam-14214	94	103	et	et	PROPN
bam-14214	94	104	al	al	PROPN
bam-14214	94	105	.	.	PROPN
bam-14214	94	106	reported	report	VERB
bam-14214	94	107	that	that	SCONJ
bam-14214	94	108	resistance	resistance	NOUN
bam-14214	94	109	training	training	NOUN
bam-14214	94	110	in	in	ADP
bam-14214	94	111	rats	rat	NOUN
bam-14214	94	112	enhanced	enhance	VERB
bam-14214	94	113	hsp70	hsp70	NOUN
bam-14214	94	114	expression	expression	NOUN
bam-14214	94	115	in	in	ADP
bam-14214	94	116	skeletal	skeletal	ADJ
bam-14214	94	117	muscle	muscle	NOUN
bam-14214	94	118	,	,	PUNCT
bam-14214	94	119	supporting	support	VERB
bam-14214	94	120	its	its	PRON
bam-14214	94	121	role	role	NOUN
bam-14214	94	122	in	in	ADP
bam-14214	94	123	cellular	cellular	ADJ
bam-14214	94	124	protection	protection	NOUN
bam-14214	94	125	and	and	CCONJ
bam-14214	94	126	stress	stress	NOUN
bam-14214	94	127	response.18	response.18	VERB
bam-14214	94	128	our	our	PRON
bam-14214	94	129	results	result	NOUN
bam-14214	94	130	align	align	VERB
bam-14214	94	131	with	with	ADP
bam-14214	94	132	these	these	DET
bam-14214	94	133	findings	finding	NOUN
bam-14214	94	134	,	,	PUNCT
bam-14214	94	135	as	as	SCONJ
bam-14214	94	136	both	both	PRON
bam-14214	94	137	resistance	resistance	NOUN
bam-14214	94	138	and	and	CCONJ
bam-14214	94	139	endurance	endurance	NOUN
bam-14214	94	140	training	training	NOUN
bam-14214	94	141	significantly	significantly	ADV
bam-14214	94	142	upregulated	upregulate	VERB
bam-14214	94	143	klotho	klotho	NOUN
bam-14214	94	144	and	and	CCONJ
bam-14214	94	145	hsp70	hsp70	NOUN
bam-14214	94	146	expression	expression	NOUN
bam-14214	94	147	in	in	ADP
bam-14214	94	148	the	the	DET
bam-14214	94	149	renal	renal	ADJ
bam-14214	94	150	tissue	tissue	NOUN
bam-14214	94	151	of	of	ADP
bam-14214	94	152	nmri	nmri	ADJ
bam-14214	94	153	mice	mouse	NOUN
bam-14214	94	154	(	(	PUNCT
bam-14214	94	155	figure	figure	NOUN
bam-14214	94	156	2	2	NUM
bam-14214	94	157	)	)	PUNCT
bam-14214	94	158	.	.	PUNCT
bam-14214	95	1	resistance	resistance	NOUN
bam-14214	95	2	training	training	NOUN
bam-14214	95	3	exerted	exert	VERB
bam-14214	95	4	the	the	DET
bam-14214	95	5	most	most	ADV
bam-14214	95	6	pronounced	pronounced	ADJ
bam-14214	95	7	effect	effect	NOUN
bam-14214	95	8	,	,	PUNCT
bam-14214	95	9	increasing	increase	VERB
bam-14214	95	10	klotho	klotho	PROPN
bam-14214	95	11	mrna	mrna	PROPN
bam-14214	95	12	by	by	ADP
bam-14214	95	13	3.85	3.85	NUM
bam-14214	95	14	-	-	ADJ
bam-14214	95	15	fold	fold	ADJ
bam-14214	95	16	and	and	CCONJ
bam-14214	95	17	hsp70	hsp70	NOUN
bam-14214	95	18	mrna	mrna	PROPN
bam-14214	95	19	by	by	ADP
bam-14214	95	20	3.49	3.49	NUM
bam-14214	95	21	-	-	PUNCT
bam-14214	95	22	fold	fold	ADJ
bam-14214	95	23	(	(	PUNCT
bam-14214	95	24	p<0.05	p<0.05	NOUN
bam-14214	95	25	)	)	PUNCT
bam-14214	95	26	,	,	PUNCT
bam-14214	95	27	compared	compare	VERB
bam-14214	95	28	to	to	ADP
bam-14214	95	29	2.12	2.12	NUM
bam-14214	95	30	-	-	NOUN
bam-14214	95	31	fold	fold	ADJ
bam-14214	95	32	and	and	CCONJ
bam-14214	95	33	2.53	2.53	NUM
bam-14214	95	34	-	-	ADJ
bam-14214	95	35	fold	fold	ADJ
bam-14214	95	36	increases	increase	NOUN
bam-14214	95	37	,	,	PUNCT
bam-14214	95	38	respectively	respectively	ADV
bam-14214	95	39	,	,	PUNCT
bam-14214	95	40	with	with	ADP
bam-14214	95	41	9	9	NUM
bam-14214	95	42	endurance	endurance	NOUN
bam-14214	95	43	training	training	NOUN
bam-14214	95	44	(	(	PUNCT
bam-14214	95	45	p<0.05	p<0.05	NOUN
bam-14214	95	46	)	)	PUNCT
bam-14214	95	47	.	.	PUNCT
bam-14214	96	1	at	at	ADP
bam-14214	96	2	the	the	DET
bam-14214	96	3	protein	protein	NOUN
bam-14214	96	4	level	level	NOUN
bam-14214	96	5	,	,	PUNCT
bam-14214	96	6	resistance	resistance	NOUN
bam-14214	96	7	training	training	NOUN
bam-14214	96	8	led	lead	VERB
bam-14214	96	9	to	to	ADP
bam-14214	96	10	a	a	DET
bam-14214	96	11	3.48	3.48	NUM
bam-14214	96	12	-	-	ADJ
bam-14214	96	13	fold	fold	ADJ
bam-14214	96	14	increase	increase	NOUN
bam-14214	96	15	in	in	ADP
bam-14214	96	16	klotho	klotho	PROPN
bam-14214	96	17	and	and	CCONJ
bam-14214	96	18	a	a	DET
bam-14214	96	19	2.80	2.80	NUM
bam-14214	96	20	-	-	ADJ
bam-14214	96	21	fold	fold	ADJ
bam-14214	96	22	increase	increase	NOUN
bam-14214	96	23	in	in	ADP
bam-14214	96	24	hsp70	hsp70	NOUN
bam-14214	96	25	,	,	PUNCT
bam-14214	96	26	while	while	SCONJ
bam-14214	96	27	endurance	endurance	ADJ
bam-14214	96	28	training	training	NOUN
bam-14214	96	29	induced	induce	VERB
bam-14214	96	30	more	more	ADV
bam-14214	96	31	modest	modest	ADJ
bam-14214	96	32	elevations	elevation	NOUN
bam-14214	96	33	(	(	PUNCT
bam-14214	96	34	1.50	1.50	NUM
bam-14214	96	35	-	-	NOUN
bam-14214	96	36	fold	fold	NOUN
bam-14214	96	37	for	for	ADP
bam-14214	96	38	klotho	klotho	NOUN
bam-14214	96	39	and	and	CCONJ
bam-14214	96	40	1.30	1.30	NUM
bam-14214	96	41	-	-	ADJ
bam-14214	96	42	fold	fold	ADJ
bam-14214	96	43	for	for	ADP
bam-14214	96	44	hsp70	hsp70	NOUN
bam-14214	96	45	)	)	PUNCT
bam-14214	96	46	.	.	PUNCT
bam-14214	97	1	this	this	DET
bam-14214	97	2	disparity	disparity	NOUN
bam-14214	97	3	likely	likely	ADV
bam-14214	97	4	stems	stem	VERB
bam-14214	97	5	from	from	ADP
bam-14214	97	6	the	the	DET
bam-14214	97	7	broader	broad	ADJ
bam-14214	97	8	mechanical	mechanical	ADJ
bam-14214	97	9	and	and	CCONJ
bam-14214	97	10	metabolic	metabolic	NOUN
bam-14214	97	11	stimuli	stimulus	NOUN
bam-14214	97	12	induced	induce	VERB
bam-14214	97	13	by	by	ADP
bam-14214	97	14	resistance	resistance	NOUN
bam-14214	97	15	training	training	NOUN
bam-14214	97	16	,	,	PUNCT
bam-14214	97	17	which	which	PRON
bam-14214	97	18	activate	activate	VERB
bam-14214	97	19	a	a	DET
bam-14214	97	20	more	more	ADV
bam-14214	97	21	diverse	diverse	ADJ
bam-14214	97	22	range	range	NOUN
bam-14214	97	23	of	of	ADP
bam-14214	97	24	protective	protective	ADJ
bam-14214	97	25	signaling	signal	VERB
bam-14214	97	26	pathways	pathway	NOUN
bam-14214	97	27	compared	compare	VERB
bam-14214	97	28	to	to	ADP
bam-14214	97	29	endurance	endurance	NOUN
bam-14214	97	30	training	training	NOUN
bam-14214	97	31	,	,	PUNCT
bam-14214	97	32	which	which	PRON
bam-14214	97	33	is	be	AUX
bam-14214	97	34	more	more	ADV
bam-14214	97	35	associated	associate	VERB
bam-14214	97	36	with	with	ADP
bam-14214	97	37	metabolic	metabolic	NOUN
bam-14214	97	38	health	health	NOUN
bam-14214	97	39	and	and	CCONJ
bam-14214	97	40	inflammation	inflammation	NOUN
bam-14214	97	41	reduction.19	reduction.19	NOUN
bam-14214	97	42	this	this	DET
bam-14214	97	43	distinction	distinction	NOUN
bam-14214	97	44	suggests	suggest	VERB
bam-14214	97	45	that	that	SCONJ
bam-14214	97	46	the	the	DET
bam-14214	97	47	type	type	NOUN
bam-14214	97	48	and	and	CCONJ
bam-14214	97	49	intensity	intensity	NOUN
bam-14214	97	50	of	of	ADP
bam-14214	97	51	physical	physical	ADJ
bam-14214	97	52	activity	activity	NOUN
bam-14214	97	53	may	may	AUX
bam-14214	97	54	differentially	differentially	ADV
bam-14214	97	55	influence	influence	VERB
bam-14214	97	56	anti	anti	ADJ
bam-14214	97	57	-	-	ADJ
bam-14214	97	58	aging	aging	ADJ
bam-14214	97	59	gene	gene	NOUN
bam-14214	97	60	expression	expression	NOUN
bam-14214	97	61	,	,	PUNCT
bam-14214	97	62	with	with	ADP
bam-14214	97	63	implications	implication	NOUN
bam-14214	97	64	for	for	ADP
bam-14214	97	65	designing	design	VERB
bam-14214	97	66	targeted	target	VERB
bam-14214	97	67	exercise	exercise	NOUN
bam-14214	97	68	interventions	intervention	NOUN
bam-14214	97	69	to	to	PART
bam-14214	97	70	support	support	VERB
bam-14214	97	71	renal	renal	ADJ
bam-14214	97	72	function	function	NOUN
bam-14214	97	73	and	and	CCONJ
bam-14214	97	74	systemic	systemic	ADJ
bam-14214	97	75	health	health	NOUN
bam-14214	97	76	in	in	ADP
bam-14214	97	77	populations	population	NOUN
bam-14214	97	78	at	at	ADP
bam-14214	97	79	risk	risk	NOUN
bam-14214	97	80	for	for	ADP
bam-14214	97	81	kidney	kidney	NOUN
bam-14214	97	82	dysfunction	dysfunction	NOUN
bam-14214	97	83	.	.	PUNCT
bam-14214	98	1	a	a	DET
bam-14214	98	2	key	key	ADJ
bam-14214	98	3	finding	finding	NOUN
bam-14214	98	4	of	of	ADP
bam-14214	98	5	this	this	DET
bam-14214	98	6	study	study	NOUN
bam-14214	98	7	is	be	AUX
bam-14214	98	8	the	the	DET
bam-14214	98	9	ability	ability	NOUN
bam-14214	98	10	of	of	ADP
bam-14214	98	11	exogenous	exogenous	ADJ
bam-14214	98	12	irisin	irisin	NOUN
bam-14214	98	13	to	to	PART
bam-14214	98	14	replicate	replicate	VERB
bam-14214	98	15	many	many	ADJ
bam-14214	98	16	of	of	ADP
bam-14214	98	17	the	the	DET
bam-14214	98	18	beneficial	beneficial	ADJ
bam-14214	98	19	effects	effect	NOUN
bam-14214	98	20	of	of	ADP
bam-14214	98	21	exercise	exercise	NOUN
bam-14214	98	22	,	,	PUNCT
bam-14214	98	23	supporting	support	VERB
bam-14214	98	24	its	its	PRON
bam-14214	98	25	potential	potential	NOUN
bam-14214	98	26	as	as	ADP
bam-14214	98	27	a	a	DET
bam-14214	98	28	therapeutic	therapeutic	ADJ
bam-14214	98	29	alternative	alternative	NOUN
bam-14214	98	30	for	for	ADP
bam-14214	98	31	individuals	individual	NOUN
bam-14214	98	32	unable	unable	ADJ
bam-14214	98	33	to	to	PART
bam-14214	98	34	engage	engage	VERB
bam-14214	98	35	in	in	ADP
bam-14214	98	36	physical	physical	ADJ
bam-14214	98	37	activity	activity	NOUN
bam-14214	98	38	.	.	PUNCT
bam-14214	99	1	irisin	irisin	VERB
bam-14214	99	2	injection	injection	NOUN
bam-14214	99	3	increased	increase	VERB
bam-14214	99	4	plasma	plasma	NOUN
bam-14214	99	5	irisin	irisin	NOUN
bam-14214	99	6	levels	level	NOUN
bam-14214	99	7	by	by	ADP
bam-14214	99	8	62.1	62.1	NUM
bam-14214	99	9	%	%	NOUN
bam-14214	99	10	(	(	PUNCT
bam-14214	99	11	7.27±0.66	7.27±0.66	PROPN
bam-14214	99	12	ng	ng	PROPN
bam-14214	99	13	/	/	SYM
bam-14214	99	14	ml	ml	PROPN
bam-14214	99	15	)	)	PUNCT
bam-14214	99	16	,	,	PUNCT
bam-14214	99	17	closely	closely	ADV
bam-14214	99	18	mirroring	mirror	VERB
bam-14214	99	19	the	the	DET
bam-14214	99	20	65.5	65.5	NUM
bam-14214	99	21	%	%	NOUN
bam-14214	99	22	increase	increase	NOUN
bam-14214	99	23	observed	observe	VERB
bam-14214	99	24	with	with	ADP
bam-14214	99	25	resistance	resistance	NOUN
bam-14214	99	26	training	training	NOUN
bam-14214	99	27	(	(	PUNCT
bam-14214	99	28	7.42±0.35	7.42±0.35	NOUN
bam-14214	99	29	ng	ng	PROPN
bam-14214	99	30	/	/	SYM
bam-14214	99	31	ml	ml	PROPN
bam-14214	99	32	)	)	PUNCT
bam-14214	99	33	and	and	CCONJ
bam-14214	99	34	surpassing	surpass	VERB
bam-14214	99	35	the	the	DET
bam-14214	99	36	46.7	46.7	NUM
bam-14214	99	37	%	%	NOUN
bam-14214	99	38	increase	increase	NOUN
bam-14214	99	39	with	with	ADP
bam-14214	99	40	endurance	endurance	NOUN
bam-14214	99	41	training	training	NOUN
bam-14214	99	42	(	(	PUNCT
bam-14214	99	43	6.38±0.65	6.38±0.65	NUM
bam-14214	99	44	ng	ng	PROPN
bam-14214	99	45	/	/	SYM
bam-14214	99	46	ml	ml	PROPN
bam-14214	99	47	)	)	PUNCT
bam-14214	99	48	(	(	PUNCT
bam-14214	99	49	figure	figure	NOUN
bam-14214	99	50	1	1	NUM
bam-14214	99	51	)	)	PUNCT
bam-14214	99	52	.	.	PUNCT
bam-14214	100	1	irisin	irisin	VERB
bam-14214	100	2	injection	injection	NOUN
bam-14214	100	3	also	also	ADV
bam-14214	100	4	significantly	significantly	ADV
bam-14214	100	5	upregulated	upregulate	VERB
bam-14214	100	6	klotho	klotho	NOUN
bam-14214	100	7	and	and	CCONJ
bam-14214	100	8	hsp70	hsp70	NOUN
bam-14214	100	9	expression	expression	NOUN
bam-14214	100	10	at	at	ADP
bam-14214	100	11	both	both	CCONJ
bam-14214	100	12	mrna	mrna	NOUN
bam-14214	100	13	and	and	CCONJ
bam-14214	100	14	protein	protein	NOUN
bam-14214	100	15	levels	level	NOUN
bam-14214	100	16	,	,	PUNCT
bam-14214	100	17	with	with	ADP
bam-14214	100	18	effects	effect	NOUN
bam-14214	100	19	comparable	comparable	ADJ
bam-14214	100	20	to	to	ADP
bam-14214	100	21	those	those	PRON
bam-14214	100	22	of	of	ADP
bam-14214	100	23	resistance	resistance	NOUN
bam-14214	100	24	and	and	CCONJ
bam-14214	100	25	endurance	endurance	NOUN
bam-14214	100	26	training	training	NOUN
bam-14214	100	27	(	(	PUNCT
bam-14214	100	28	figure	figure	NOUN
bam-14214	100	29	2	2	NUM
bam-14214	100	30	)	)	PUNCT
bam-14214	100	31	.	.	PUNCT
bam-14214	101	1	these	these	DET
bam-14214	101	2	findings	finding	NOUN
bam-14214	101	3	are	be	AUX
bam-14214	101	4	consistent	consistent	ADJ
bam-14214	101	5	with	with	ADP
bam-14214	101	6	prior	prior	ADJ
bam-14214	101	7	studies	study	NOUN
bam-14214	101	8	reporting	report	VERB
bam-14214	101	9	that	that	SCONJ
bam-14214	101	10	irisin	irisin	NOUN
bam-14214	101	11	,	,	PUNCT
bam-14214	101	12	a	a	DET
bam-14214	101	13	myokine	myokine	NOUN
bam-14214	101	14	released	release	VERB
bam-14214	101	15	during	during	ADP
bam-14214	101	16	exercise	exercise	NOUN
bam-14214	101	17	,	,	PUNCT
bam-14214	101	18	can	can	AUX
bam-14214	101	19	mimic	mimic	VERB
bam-14214	101	20	exercise	exercise	NOUN
bam-14214	101	21	-	-	PUNCT
bam-14214	101	22	induced	induce	VERB
bam-14214	101	23	benefits	benefit	NOUN
bam-14214	101	24	by	by	ADP
bam-14214	101	25	enhancing	enhance	VERB
bam-14214	101	26	metabolism	metabolism	NOUN
bam-14214	101	27	and	and	CCONJ
bam-14214	101	28	upregulating	upregulating	ADJ
bam-14214	101	29	protective	protective	ADJ
bam-14214	101	30	gene	gene	NOUN
bam-14214	101	31	expression.12,20,21	expression.12,20,21	ADP
bam-14214	101	32	the	the	DET
bam-14214	101	33	mechanism	mechanism	NOUN
bam-14214	101	34	underlying	underlie	VERB
bam-14214	101	35	irisin	irisin	NOUN
bam-14214	101	36	’s	’s	PART
bam-14214	101	37	effects	effect	NOUN
bam-14214	101	38	likely	likely	ADV
bam-14214	101	39	involves	involve	VERB
bam-14214	101	40	the	the	DET
bam-14214	101	41	activation	activation	NOUN
bam-14214	101	42	of	of	ADP
bam-14214	101	43	pgc1α	pgc1α	PROPN
bam-14214	101	44	and	and	CCONJ
bam-14214	101	45	fndc5	fndc5	PROPN
bam-14214	101	46	in	in	ADP
bam-14214	101	47	skeletal	skeletal	ADJ
bam-14214	101	48	muscle	muscle	NOUN
bam-14214	101	49	,	,	PUNCT
bam-14214	101	50	leading	lead	VERB
bam-14214	101	51	to	to	ADP
bam-14214	101	52	irisin	irisin	NOUN
bam-14214	101	53	production	production	NOUN
bam-14214	101	54	,	,	PUNCT
bam-14214	101	55	which	which	PRON
bam-14214	101	56	subsequently	subsequently	ADV
bam-14214	101	57	engages	engage	VERB
bam-14214	101	58	downstream	downstream	ADJ
bam-14214	101	59	pathways	pathway	NOUN
bam-14214	101	60	such	such	ADJ
bam-14214	101	61	as	as	ADP
bam-14214	101	62	mapk	mapk	NOUN
bam-14214	101	63	and	and	CCONJ
bam-14214	101	64	pi3k	pi3k	PROPN
bam-14214	101	65	/	/	SYM
bam-14214	101	66	akt	akt	PROPN
bam-14214	101	67	in	in	ADP
bam-14214	101	68	target	target	NOUN
bam-14214	101	69	tissues	tissue	NOUN
bam-14214	101	70	like	like	ADP
bam-14214	101	71	the	the	DET
bam-14214	101	72	kidney.22,25	kidney.22,25	NOUN
bam-14214	101	73	these	these	DET
bam-14214	101	74	pathways	pathway	NOUN
bam-14214	101	75	may	may	AUX
bam-14214	101	76	enhance	enhance	VERB
bam-14214	101	77	mitochondrial	mitochondrial	ADJ
bam-14214	101	78	function	function	NOUN
bam-14214	101	79	,	,	PUNCT
bam-14214	101	80	reduce	reduce	VERB
bam-14214	101	81	oxidative	oxidative	ADJ
bam-14214	101	82	damage	damage	NOUN
bam-14214	101	83	,	,	PUNCT
bam-14214	101	84	and	and	CCONJ
bam-14214	101	85	upregulate	upregulate	VERB
bam-14214	101	86	longevityrelated	longevityrelated	ADJ
bam-14214	101	87	genes	gene	NOUN
bam-14214	101	88	,	,	PUNCT
bam-14214	101	89	thereby	thereby	ADV
bam-14214	101	90	protecting	protect	VERB
bam-14214	101	91	against	against	ADP
bam-14214	101	92	renal	renal	ADJ
bam-14214	101	93	stress	stress	NOUN
bam-14214	101	94	and	and	CCONJ
bam-14214	101	95	injury	injury	NOUN
bam-14214	101	96	—	—	PUNCT
bam-14214	101	97	a	a	DET
bam-14214	101	98	critical	critical	ADJ
bam-14214	101	99	consideration	consideration	NOUN
bam-14214	101	100	given	give	VERB
bam-14214	101	101	the	the	DET
bam-14214	101	102	kidney	kidney	NOUN
bam-14214	101	103	’s	’s	PART
bam-14214	101	104	vulnerability	vulnerability	NOUN
bam-14214	101	105	to	to	ADP
bam-14214	101	106	age	age	NOUN
bam-14214	101	107	-	-	PUNCT
bam-14214	101	108	related	relate	VERB
bam-14214	101	109	decline	decline	NOUN
bam-14214	101	110	.	.	PUNCT
bam-14214	102	1	for	for	ADP
bam-14214	102	2	instance	instance	NOUN
bam-14214	102	3	,	,	PUNCT
bam-14214	102	4	a	a	DET
bam-14214	102	5	recent	recent	ADJ
bam-14214	102	6	study	study	NOUN
bam-14214	102	7	demonstrated	demonstrate	VERB
bam-14214	102	8	that	that	SCONJ
bam-14214	102	9	irisin	irisin	PROPN
bam-14214	102	10	administration	administration	NOUN
bam-14214	102	11	in	in	ADP
bam-14214	102	12	a	a	DET
bam-14214	102	13	mouse	mouse	NOUN
bam-14214	102	14	model	model	NOUN
bam-14214	102	15	of	of	ADP
bam-14214	102	16	renal	renal	ADJ
bam-14214	102	17	ischemia	ischemia	NOUN
bam-14214	102	18	-	-	PUNCT
bam-14214	102	19	reperfusion	reperfusion	NOUN
bam-14214	102	20	injury	injury	NOUN
bam-14214	102	21	reduced	reduce	VERB
bam-14214	102	22	levels	level	NOUN
bam-14214	102	23	of	of	ADP
bam-14214	102	24	renal	renal	ADJ
bam-14214	102	25	injury	injury	NOUN
bam-14214	102	26	markers	marker	NOUN
bam-14214	102	27	(	(	PUNCT
bam-14214	102	28	e.g.	e.g.	ADV
bam-14214	102	29	,	,	PUNCT
bam-14214	102	30	serum	serum	NOUN
bam-14214	102	31	creatinine	creatinine	NOUN
bam-14214	102	32	,	,	PUNCT
bam-14214	102	33	bun	bun	PROPN
bam-14214	102	34	,	,	PUNCT
bam-14214	102	35	kim-1	kim-1	X
bam-14214	102	36	,	,	PUNCT
bam-14214	102	37	and	and	CCONJ
bam-14214	102	38	ngal	ngal	ADJ
bam-14214	102	39	)	)	PUNCT
bam-14214	102	40	and	and	CCONJ
bam-14214	102	41	preserved	preserve	VERB
bam-14214	102	42	mitochondrial	mitochondrial	ADJ
bam-14214	102	43	integrity	integrity	NOUN
bam-14214	102	44	by	by	ADP
bam-14214	102	45	upregulating	upregulate	VERB
bam-14214	102	46	autophagy	autophagy	ADV
bam-14214	102	47	-	-	PUNCT
bam-14214	102	48	related	relate	VERB
bam-14214	102	49	proteins	protein	NOUN
bam-14214	102	50	(	(	PUNCT
bam-14214	102	51	pink1	pink1	NOUN
bam-14214	102	52	,	,	PUNCT
bam-14214	102	53	park2	park2	NOUN
bam-14214	102	54	,	,	PUNCT
bam-14214	102	55	lc3	lc3	NOUN
bam-14214	102	56	)	)	PUNCT
bam-14214	102	57	while	while	SCONJ
bam-14214	102	58	downregulating	downregulate	VERB
bam-14214	102	59	mitochondrial	mitochondrial	ADJ
bam-14214	102	60	membrane	membrane	NOUN
bam-14214	102	61	proteins	protein	NOUN
bam-14214	102	62	(	(	PUNCT
bam-14214	102	63	tom20	tom20	NOUN
bam-14214	102	64	,	,	PUNCT
bam-14214	102	65	tim23	tim23	NOUN
bam-14214	102	66	)	)	PUNCT
bam-14214	102	67	,	,	PUNCT
bam-14214	102	68	highlighting	highlight	VERB
bam-14214	102	69	its	its	PRON
bam-14214	102	70	renoprotective	renoprotective	ADJ
bam-14214	102	71	potential.26	potential.26	ADJ
bam-14214	102	72	correlation	correlation	NOUN
bam-14214	102	73	analyses	analysis	NOUN
bam-14214	102	74	further	far	ADV
bam-14214	102	75	elucidate	elucidate	VERB
bam-14214	102	76	irisin	irisin	NOUN
bam-14214	102	77	’s	’s	PART
bam-14214	102	78	regulatory	regulatory	ADJ
bam-14214	102	79	role	role	NOUN
bam-14214	102	80	,	,	PUNCT
bam-14214	102	81	revealing	reveal	VERB
bam-14214	102	82	a	a	DET
bam-14214	102	83	strong	strong	ADJ
bam-14214	102	84	positive	positive	ADJ
bam-14214	102	85	correlation	correlation	NOUN
bam-14214	102	86	between	between	ADP
bam-14214	102	87	plasma	plasma	NOUN
bam-14214	102	88	irisin	irisin	NOUN
bam-14214	102	89	levels	level	NOUN
bam-14214	102	90	and	and	CCONJ
bam-14214	102	91	klotho	klotho	VERB
bam-14214	102	92	mrna	mrna	PROPN
bam-14214	102	93	expression	expression	NOUN
bam-14214	102	94	(	(	PUNCT
bam-14214	102	95	r=0.9498	r=0.9498	PROPN
bam-14214	102	96	,	,	PUNCT
bam-14214	102	97	p<0.0001	p<0.0001	NOUN
bam-14214	102	98	)	)	PUNCT
bam-14214	102	99	,	,	PUNCT
bam-14214	102	100	suggesting	suggest	VERB
bam-14214	102	101	that	that	DET
bam-14214	102	102	irisin	irisin	NOUN
bam-14214	102	103	may	may	AUX
bam-14214	102	104	directly	directly	ADV
bam-14214	102	105	enhance	enhance	VERB
bam-14214	102	106	klotho	klotho	ADJ
bam-14214	102	107	expression	expression	NOUN
bam-14214	102	108	,	,	PUNCT
bam-14214	102	109	a	a	DET
bam-14214	102	110	protein	protein	NOUN
bam-14214	102	111	with	with	ADP
bam-14214	102	112	well	well	ADV
bam-14214	102	113	-	-	PUNCT
bam-14214	102	114	documented	document	VERB
bam-14214	102	115	anti	anti	ADJ
bam-14214	102	116	-	-	ADJ
bam-14214	102	117	aging	aging	ADJ
bam-14214	102	118	and	and	CCONJ
bam-14214	102	119	renoprotective	renoprotective	ADJ
bam-14214	102	120	properties	property	NOUN
bam-14214	102	121	(	(	PUNCT
bam-14214	102	122	figure	figure	NOUN
bam-14214	102	123	2	2	NUM
bam-14214	102	124	)	)	PUNCT
bam-14214	102	125	.	.	PUNCT
bam-14214	103	1	a	a	DET
bam-14214	103	2	more	more	ADV
bam-14214	103	3	moderate	moderate	ADJ
bam-14214	103	4	but	but	CCONJ
bam-14214	103	5	significant	significant	ADJ
bam-14214	103	6	correlation	correlation	NOUN
bam-14214	103	7	was	be	AUX
bam-14214	103	8	observed	observe	VERB
bam-14214	103	9	with	with	ADP
bam-14214	103	10	hsp70	hsp70	NOUN
bam-14214	103	11	expression	expression	NOUN
bam-14214	103	12	(	(	PUNCT
bam-14214	103	13	r=0.7511	r=0.7511	PROPN
bam-14214	103	14	,	,	PUNCT
bam-14214	103	15	p<0.003	p<0.003	NOUN
bam-14214	103	16	)	)	PUNCT
bam-14214	103	17	,	,	PUNCT
bam-14214	103	18	indicating	indicate	VERB
bam-14214	103	19	that	that	SCONJ
bam-14214	103	20	irisin	irisin	NOUN
bam-14214	103	21	also	also	ADV
bam-14214	103	22	influences	influence	VERB
bam-14214	103	23	stress	stress	NOUN
bam-14214	103	24	-	-	PUNCT
bam-14214	103	25	protective	protective	ADJ
bam-14214	103	26	10	10	NUM
bam-14214	103	27	pathways	pathway	NOUN
bam-14214	103	28	,	,	PUNCT
bam-14214	103	29	albeit	albeit	SCONJ
bam-14214	103	30	to	to	ADP
bam-14214	103	31	a	a	DET
bam-14214	103	32	lesser	less	ADJ
bam-14214	103	33	extent	extent	NOUN
bam-14214	103	34	(	(	PUNCT
bam-14214	103	35	figure	figure	NOUN
bam-14214	103	36	2	2	NUM
bam-14214	103	37	)	)	PUNCT
bam-14214	103	38	.	.	PUNCT
bam-14214	104	1	the	the	DET
bam-14214	104	2	coordinated	coordinate	VERB
bam-14214	104	3	upregulation	upregulation	NOUN
bam-14214	104	4	of	of	ADP
bam-14214	104	5	klotho	klotho	PROPN
bam-14214	104	6	and	and	CCONJ
bam-14214	104	7	hsp70	hsp70	PROPN
bam-14214	104	8	suggests	suggest	VERB
bam-14214	104	9	a	a	DET
bam-14214	104	10	potential	potential	ADJ
bam-14214	104	11	synergistic	synergistic	ADJ
bam-14214	104	12	effect	effect	NOUN
bam-14214	104	13	in	in	ADP
bam-14214	104	14	mitigating	mitigate	VERB
bam-14214	104	15	oxidative	oxidative	ADJ
bam-14214	104	16	stress	stress	NOUN
bam-14214	104	17	and	and	CCONJ
bam-14214	104	18	inflammation	inflammation	NOUN
bam-14214	104	19	,	,	PUNCT
bam-14214	104	20	key	key	ADJ
bam-14214	104	21	drivers	driver	NOUN
bam-14214	104	22	of	of	ADP
bam-14214	104	23	renal	renal	ADJ
bam-14214	104	24	injury	injury	NOUN
bam-14214	104	25	and	and	CCONJ
bam-14214	104	26	aging	aging	NOUN
bam-14214	104	27	.	.	PUNCT
bam-14214	105	1	this	this	PRON
bam-14214	105	2	is	be	AUX
bam-14214	105	3	supported	support	VERB
bam-14214	105	4	by	by	ADP
bam-14214	105	5	sugiura	sugiura	NOUN
bam-14214	105	6	et	et	PROPN
bam-14214	105	7	al	al	PROPN
bam-14214	105	8	.	.	PROPN
bam-14214	105	9	,	,	PUNCT
bam-14214	105	10	who	who	PRON
bam-14214	105	11	demonstrated	demonstrate	VERB
bam-14214	105	12	that	that	SCONJ
bam-14214	105	13	klotho	klotho	PROPN
bam-14214	105	14	gene	gene	NOUN
bam-14214	105	15	therapy	therapy	NOUN
bam-14214	105	16	in	in	ADP
bam-14214	105	17	a	a	DET
bam-14214	105	18	mouse	mouse	NOUN
bam-14214	105	19	model	model	NOUN
bam-14214	105	20	of	of	ADP
bam-14214	105	21	renal	renal	ADJ
bam-14214	105	22	ischemia	ischemia	NOUN
bam-14214	105	23	-	-	PUNCT
bam-14214	105	24	reperfusion	reperfusion	NOUN
bam-14214	105	25	injury	injury	NOUN
bam-14214	105	26	reduced	reduce	VERB
bam-14214	105	27	apoptosis	apoptosis	NOUN
bam-14214	105	28	by	by	ADP
bam-14214	105	29	upregulating	upregulating	ADJ
bam-14214	105	30	hsp70	hsp70	NOUN
bam-14214	105	31	,	,	PUNCT
bam-14214	105	32	highlighting	highlight	VERB
bam-14214	105	33	klotho	klotho	PROPN
bam-14214	105	34	’s	’s	PART
bam-14214	105	35	role	role	NOUN
bam-14214	105	36	in	in	ADP
bam-14214	105	37	oxidative	oxidative	ADJ
bam-14214	105	38	stress	stress	NOUN
bam-14214	105	39	mitigation.27	mitigation.27	PROPN
bam-14214	105	40	additionally	additionally	ADV
bam-14214	105	41	,	,	PUNCT
bam-14214	105	42	a	a	DET
bam-14214	105	43	recent	recent	ADJ
bam-14214	105	44	study	study	NOUN
bam-14214	105	45	found	find	VERB
bam-14214	105	46	a	a	DET
bam-14214	105	47	positive	positive	ADJ
bam-14214	105	48	correlation	correlation	NOUN
bam-14214	105	49	between	between	ADP
bam-14214	105	50	hippocampal	hippocampal	ADJ
bam-14214	105	51	irisin	irisin	NOUN
bam-14214	105	52	levels	level	NOUN
bam-14214	105	53	and	and	CCONJ
bam-14214	105	54	hsp70	hsp70	NOUN
bam-14214	105	55	expression	expression	NOUN
bam-14214	105	56	in	in	ADP
bam-14214	105	57	rats	rat	NOUN
bam-14214	105	58	with	with	ADP
bam-14214	105	59	high	high	ADJ
bam-14214	105	60	-	-	PUNCT
bam-14214	105	61	fat	fat	ADJ
bam-14214	105	62	,	,	PUNCT
bam-14214	105	63	high	high	ADJ
bam-14214	105	64	-	-	PUNCT
bam-14214	105	65	fructose	fructose	NOUN
bam-14214	105	66	diet	diet	NOUN
bam-14214	105	67	-	-	PUNCT
bam-14214	105	68	induced	induce	VERB
bam-14214	105	69	cognitive	cognitive	ADJ
bam-14214	105	70	dysfunction	dysfunction	NOUN
bam-14214	105	71	,	,	PUNCT
bam-14214	105	72	suggesting	suggest	VERB
bam-14214	105	73	that	that	SCONJ
bam-14214	105	74	irisin	irisin	NOUN
bam-14214	105	75	contributes	contribute	VERB
bam-14214	105	76	to	to	ADP
bam-14214	105	77	stress	stress	NOUN
bam-14214	105	78	response	response	NOUN
bam-14214	105	79	pathways	pathway	NOUN
bam-14214	105	80	across	across	ADP
bam-14214	105	81	different	different	ADJ
bam-14214	105	82	tissues.28	tissues.28	NOUN
bam-14214	105	83	although	although	SCONJ
bam-14214	105	84	our	our	PRON
bam-14214	105	85	primary	primary	ADJ
bam-14214	105	86	focus	focus	NOUN
bam-14214	105	87	was	be	AUX
bam-14214	105	88	on	on	ADP
bam-14214	105	89	the	the	DET
bam-14214	105	90	molecular	molecular	ADJ
bam-14214	105	91	modulation	modulation	NOUN
bam-14214	105	92	of	of	ADP
bam-14214	105	93	anti	anti	ADJ
bam-14214	105	94	-	-	ADJ
bam-14214	105	95	aging	aging	ADJ
bam-14214	105	96	pathways	pathway	NOUN
bam-14214	105	97	,	,	PUNCT
bam-14214	105	98	we	we	PRON
bam-14214	105	99	also	also	ADV
bam-14214	105	100	conducted	conduct	VERB
bam-14214	105	101	an	an	DET
bam-14214	105	102	exploratory	exploratory	ADJ
bam-14214	105	103	long	long	ADJ
bam-14214	105	104	-	-	PUNCT
bam-14214	105	105	term	term	NOUN
bam-14214	105	106	survival	survival	NOUN
bam-14214	105	107	analysis	analysis	NOUN
bam-14214	105	108	to	to	PART
bam-14214	105	109	evaluate	evaluate	VERB
bam-14214	105	110	whether	whether	SCONJ
bam-14214	105	111	early	early	ADJ
bam-14214	105	112	-	-	PUNCT
bam-14214	105	113	life	life	NOUN
bam-14214	105	114	interventions	intervention	NOUN
bam-14214	105	115	could	could	AUX
bam-14214	105	116	influence	influence	VERB
bam-14214	105	117	longevity	longevity	NOUN
bam-14214	105	118	trajectories	trajectory	NOUN
bam-14214	105	119	.	.	PUNCT
bam-14214	106	1	despite	despite	SCONJ
bam-14214	106	2	the	the	DET
bam-14214	106	3	lack	lack	NOUN
bam-14214	106	4	of	of	ADP
bam-14214	106	5	statistically	statistically	ADV
bam-14214	106	6	significant	significant	ADJ
bam-14214	106	7	differences	difference	NOUN
bam-14214	106	8	among	among	ADP
bam-14214	106	9	groups	group	NOUN
bam-14214	106	10	based	base	VERB
bam-14214	106	11	on	on	ADP
bam-14214	106	12	the	the	DET
bam-14214	106	13	log	log	NOUN
bam-14214	106	14	-	-	PUNCT
bam-14214	106	15	rank	rank	NOUN
bam-14214	106	16	(	(	PUNCT
bam-14214	106	17	mantel	mantel	NOUN
bam-14214	106	18	-	-	PUNCT
bam-14214	106	19	cox	cox	NOUN
bam-14214	106	20	)	)	PUNCT
bam-14214	106	21	test	test	NOUN
bam-14214	106	22	(	(	PUNCT
bam-14214	106	23	p=0.093	p=0.093	NUM
bam-14214	106	24	)	)	PUNCT
bam-14214	106	25	,	,	PUNCT
bam-14214	106	26	a	a	DET
bam-14214	106	27	significant	significant	ADJ
bam-14214	106	28	linear	linear	ADJ
bam-14214	106	29	trend	trend	NOUN
bam-14214	106	30	was	be	AUX
bam-14214	106	31	detected	detect	VERB
bam-14214	106	32	using	use	VERB
bam-14214	106	33	the	the	DET
bam-14214	106	34	log	log	NOUN
bam-14214	106	35	-	-	PUNCT
bam-14214	106	36	rank	rank	NOUN
bam-14214	106	37	test	test	NOUN
bam-14214	106	38	for	for	ADP
bam-14214	106	39	trend	trend	NOUN
bam-14214	106	40	(	(	PUNCT
bam-14214	106	41	p=0.042	p=0.042	NUM
bam-14214	106	42	)	)	PUNCT
bam-14214	106	43	,	,	PUNCT
bam-14214	106	44	indicating	indicate	VERB
bam-14214	106	45	a	a	DET
bam-14214	106	46	potential	potential	ADJ
bam-14214	106	47	dose	dose	NOUN
bam-14214	106	48	–	–	PUNCT
bam-14214	106	49	response	response	NOUN
bam-14214	106	50	relationship	relationship	NOUN
bam-14214	106	51	between	between	ADP
bam-14214	106	52	intervention	intervention	NOUN
bam-14214	106	53	intensity	intensity	NOUN
bam-14214	106	54	and	and	CCONJ
bam-14214	106	55	survival	survival	NOUN
bam-14214	106	56	benefit	benefit	NOUN
bam-14214	106	57	.	.	PUNCT
bam-14214	107	1	by	by	ADP
bam-14214	107	2	the	the	DET
bam-14214	107	3	end	end	NOUN
bam-14214	107	4	of	of	ADP
bam-14214	107	5	the	the	DET
bam-14214	107	6	20	20	NUM
bam-14214	107	7	-	-	PUNCT
bam-14214	107	8	month	month	NOUN
bam-14214	107	9	follow	follow	NOUN
bam-14214	107	10	-	-	PUNCT
bam-14214	107	11	up	up	NOUN
bam-14214	107	12	,	,	PUNCT
bam-14214	107	13	the	the	DET
bam-14214	107	14	control	control	NOUN
bam-14214	107	15	group	group	NOUN
bam-14214	107	16	exhibited	exhibit	VERB
bam-14214	107	17	the	the	DET
bam-14214	107	18	highest	high	ADJ
bam-14214	107	19	mortality	mortality	NOUN
bam-14214	107	20	(	(	PUNCT
bam-14214	107	21	8/12	8/12	NUM
bam-14214	107	22	)	)	PUNCT
bam-14214	107	23	,	,	PUNCT
bam-14214	107	24	while	while	SCONJ
bam-14214	107	25	the	the	DET
bam-14214	107	26	resistance	resistance	NOUN
bam-14214	107	27	training	training	NOUN
bam-14214	107	28	group	group	NOUN
bam-14214	107	29	showed	show	VERB
bam-14214	107	30	the	the	DET
bam-14214	107	31	lowest	low	ADJ
bam-14214	107	32	(	(	PUNCT
bam-14214	107	33	3/12	3/12	NUM
bam-14214	107	34	)	)	PUNCT
bam-14214	107	35	,	,	PUNCT
bam-14214	107	36	followed	follow	VERB
bam-14214	107	37	by	by	ADP
bam-14214	107	38	irisin	irisin	NOUN
bam-14214	107	39	injection	injection	NOUN
bam-14214	107	40	(	(	PUNCT
bam-14214	107	41	4/12	4/12	NUM
bam-14214	107	42	)	)	PUNCT
bam-14214	107	43	and	and	CCONJ
bam-14214	107	44	endurance	endurance	NOUN
bam-14214	107	45	training	training	NOUN
bam-14214	107	46	(	(	PUNCT
bam-14214	107	47	5/12	5/12	NUM
bam-14214	107	48	)	)	PUNCT
bam-14214	107	49	.	.	PUNCT
bam-14214	108	1	notably	notably	ADV
bam-14214	108	2	,	,	PUNCT
bam-14214	108	3	the	the	DET
bam-14214	108	4	median	median	ADJ
bam-14214	108	5	survival	survival	NOUN
bam-14214	108	6	time	time	NOUN
bam-14214	108	7	was	be	AUX
bam-14214	108	8	reached	reach	VERB
bam-14214	108	9	only	only	ADV
bam-14214	108	10	in	in	ADP
bam-14214	108	11	the	the	DET
bam-14214	108	12	control	control	NOUN
bam-14214	108	13	group	group	NOUN
bam-14214	108	14	(	(	PUNCT
bam-14214	108	15	480	480	NUM
bam-14214	108	16	days	day	NOUN
bam-14214	108	17	)	)	PUNCT
bam-14214	108	18	,	,	PUNCT
bam-14214	108	19	whereas	whereas	SCONJ
bam-14214	108	20	it	it	PRON
bam-14214	108	21	remained	remain	VERB
bam-14214	108	22	undefined	undefined	ADJ
bam-14214	108	23	in	in	ADP
bam-14214	108	24	all	all	DET
bam-14214	108	25	intervention	intervention	NOUN
bam-14214	108	26	groups	group	NOUN
bam-14214	108	27	—	—	PUNCT
bam-14214	108	28	suggesting	suggest	VERB
bam-14214	108	29	prolonged	prolonged	ADJ
bam-14214	108	30	survival	survival	NOUN
bam-14214	108	31	.	.	PUNCT
bam-14214	109	1	these	these	DET
bam-14214	109	2	findings	finding	NOUN
bam-14214	109	3	align	align	VERB
bam-14214	109	4	with	with	ADP
bam-14214	109	5	growing	grow	VERB
bam-14214	109	6	evidence	evidence	NOUN
bam-14214	109	7	that	that	SCONJ
bam-14214	109	8	early	early	ADJ
bam-14214	109	9	-	-	PUNCT
bam-14214	109	10	life	life	NOUN
bam-14214	109	11	molecular	molecular	ADJ
bam-14214	109	12	enhancement	enhancement	NOUN
bam-14214	109	13	—	—	PUNCT
bam-14214	109	14	particularly	particularly	ADV
bam-14214	109	15	via	via	ADP
bam-14214	109	16	klotho	klotho	PROPN
bam-14214	109	17	and	and	CCONJ
bam-14214	109	18	hsp70	hsp70	NOUN
bam-14214	109	19	—	—	PUNCT
bam-14214	109	20	may	may	AUX
bam-14214	109	21	contribute	contribute	VERB
bam-14214	109	22	to	to	ADP
bam-14214	109	23	long	long	ADJ
bam-14214	109	24	-	-	PUNCT
bam-14214	109	25	term	term	NOUN
bam-14214	109	26	physiological	physiological	ADJ
bam-14214	109	27	resilience	resilience	NOUN
bam-14214	109	28	.	.	PUNCT
bam-14214	110	1	for	for	ADP
bam-14214	110	2	instance	instance	NOUN
bam-14214	110	3	,	,	PUNCT
bam-14214	110	4	feng	feng	PROPN
bam-14214	110	5	et	et	PROPN
bam-14214	110	6	al	al	PROPN
bam-14214	110	7	.	.	PROPN
bam-14214	110	8	reported	report	VERB
bam-14214	110	9	that	that	SCONJ
bam-14214	110	10	three	three	NUM
bam-14214	110	11	months	month	NOUN
bam-14214	110	12	of	of	ADP
bam-14214	110	13	swimming	swimming	NOUN
bam-14214	110	14	exercise	exercise	NOUN
bam-14214	110	15	in	in	ADP
bam-14214	110	16	young	young	ADJ
bam-14214	110	17	c57bl/6j	c57bl/6j	NOUN
bam-14214	110	18	mice	mouse	NOUN
bam-14214	110	19	significantly	significantly	ADV
bam-14214	110	20	extended	extend	VERB
bam-14214	110	21	healthspan	healthspan	NOUN
bam-14214	110	22	,	,	PUNCT
bam-14214	110	23	though	though	SCONJ
bam-14214	110	24	not	not	PART
bam-14214	110	25	lifespan	lifespan	VERB
bam-14214	110	26	,	,	PUNCT
bam-14214	110	27	supporting	support	VERB
bam-14214	110	28	the	the	DET
bam-14214	110	29	concept	concept	NOUN
bam-14214	110	30	that	that	SCONJ
bam-14214	110	31	early	early	ADJ
bam-14214	110	32	interventions	intervention	NOUN
bam-14214	110	33	confer	confer	VERB
bam-14214	110	34	persistent	persistent	ADJ
bam-14214	110	35	systemic	systemic	ADJ
bam-14214	110	36	benefits.29	benefits.29	NOUN
bam-14214	110	37	our	our	PRON
bam-14214	110	38	data	datum	NOUN
bam-14214	110	39	complement	complement	VERB
bam-14214	110	40	this	this	DET
bam-14214	110	41	concept	concept	NOUN
bam-14214	110	42	by	by	ADP
bam-14214	110	43	showing	show	VERB
bam-14214	110	44	a	a	DET
bam-14214	110	45	modest	modest	ADJ
bam-14214	110	46	,	,	PUNCT
bam-14214	110	47	yet	yet	CCONJ
bam-14214	110	48	consistent	consistent	ADJ
bam-14214	110	49	trend	trend	NOUN
bam-14214	110	50	toward	toward	ADP
bam-14214	110	51	improved	improved	ADJ
bam-14214	110	52	survival	survival	NOUN
bam-14214	110	53	following	follow	VERB
bam-14214	110	54	early	early	ADJ
bam-14214	110	55	resistance	resistance	NOUN
bam-14214	110	56	training	training	NOUN
bam-14214	110	57	or	or	CCONJ
bam-14214	110	58	irisin	irisin	PROPN
bam-14214	110	59	administration	administration	NOUN
bam-14214	110	60	.	.	PUNCT
bam-14214	111	1	moreover	moreover	ADV
bam-14214	111	2	,	,	PUNCT
bam-14214	111	3	our	our	PRON
bam-14214	111	4	results	result	NOUN
bam-14214	111	5	resonate	resonate	VERB
bam-14214	111	6	with	with	ADP
bam-14214	111	7	studies	study	NOUN
bam-14214	111	8	demonstrating	demonstrate	VERB
bam-14214	111	9	that	that	PRON
bam-14214	111	10	increased	increase	VERB
bam-14214	111	11	klotho	klotho	ADJ
bam-14214	111	12	expression	expression	NOUN
bam-14214	111	13	extends	extend	VERB
bam-14214	111	14	lifespan	lifespan	VERB
bam-14214	111	15	and	and	CCONJ
bam-14214	111	16	attenuates	attenuate	NOUN
bam-14214	111	17	agerelated	agerelate	VERB
bam-14214	111	18	tissue	tissue	NOUN
bam-14214	111	19	degeneration	degeneration	NOUN
bam-14214	111	20	,	,	PUNCT
bam-14214	111	21	and	and	CCONJ
bam-14214	111	22	that	that	SCONJ
bam-14214	111	23	preconditioning	precondition	VERB
bam-14214	111	24	exercise	exercise	NOUN
bam-14214	111	25	protocols	protocol	NOUN
bam-14214	111	26	can	can	AUX
bam-14214	111	27	reduce	reduce	VERB
bam-14214	111	28	mortality	mortality	NOUN
bam-14214	111	29	in	in	ADP
bam-14214	111	30	disease	disease	NOUN
bam-14214	111	31	models	model	NOUN
bam-14214	111	32	by	by	ADP
bam-14214	111	33	modulating	modulate	VERB
bam-14214	111	34	inflammation	inflammation	NOUN
bam-14214	111	35	and	and	CCONJ
bam-14214	111	36	organ	organ	VERB
bam-14214	111	37	integrity.6,30	integrity.6,30	PROPN
bam-14214	111	38	-	-	PUNCT
bam-14214	111	39	33	33	NUM
bam-14214	111	40	it	it	PRON
bam-14214	111	41	is	be	AUX
bam-14214	111	42	worth	worth	ADJ
bam-14214	111	43	emphasizing	emphasize	VERB
bam-14214	111	44	that	that	SCONJ
bam-14214	111	45	our	our	PRON
bam-14214	111	46	survival	survival	NOUN
bam-14214	111	47	data	datum	NOUN
bam-14214	111	48	were	be	AUX
bam-14214	111	49	obtained	obtain	VERB
bam-14214	111	50	in	in	ADP
bam-14214	111	51	young	young	ADJ
bam-14214	111	52	,	,	PUNCT
bam-14214	111	53	healthy	healthy	ADJ
bam-14214	111	54	animals	animal	NOUN
bam-14214	111	55	without	without	ADP
bam-14214	111	56	disease	disease	NOUN
bam-14214	111	57	burden	burden	NOUN
bam-14214	111	58	,	,	PUNCT
bam-14214	111	59	and	and	CCONJ
bam-14214	111	60	without	without	ADP
bam-14214	111	61	repeated	repeat	VERB
bam-14214	111	62	intervention	intervention	NOUN
bam-14214	111	63	post	post	NOUN
bam-14214	111	64	-	-	NOUN
bam-14214	111	65	treatment	treatment	NOUN
bam-14214	111	66	.	.	PUNCT
bam-14214	112	1	therefore	therefore	ADV
bam-14214	112	2	,	,	PUNCT
bam-14214	112	3	the	the	DET
bam-14214	112	4	observed	observed	ADJ
bam-14214	112	5	11	11	NUM
bam-14214	112	6	differences	difference	NOUN
bam-14214	112	7	in	in	ADP
bam-14214	112	8	mortality	mortality	NOUN
bam-14214	112	9	likely	likely	ADV
bam-14214	112	10	reflect	reflect	VERB
bam-14214	112	11	the	the	DET
bam-14214	112	12	long	long	ADJ
bam-14214	112	13	-	-	PUNCT
bam-14214	112	14	term	term	NOUN
bam-14214	112	15	programming	programming	NOUN
bam-14214	112	16	effects	effect	NOUN
bam-14214	112	17	of	of	ADP
bam-14214	112	18	transient	transient	ADJ
bam-14214	112	19	early	early	ADJ
bam-14214	112	20	-	-	PUNCT
bam-14214	112	21	life	life	NOUN
bam-14214	112	22	interventions	intervention	NOUN
bam-14214	112	23	,	,	PUNCT
bam-14214	112	24	rather	rather	ADV
bam-14214	112	25	than	than	ADP
bam-14214	112	26	continuous	continuous	ADJ
bam-14214	112	27	stimulation	stimulation	NOUN
bam-14214	112	28	.	.	PUNCT
bam-14214	113	1	taken	take	VERB
bam-14214	113	2	together	together	ADV
bam-14214	113	3	,	,	PUNCT
bam-14214	113	4	this	this	DET
bam-14214	113	5	study	study	NOUN
bam-14214	113	6	supports	support	VERB
bam-14214	113	7	the	the	DET
bam-14214	113	8	hypothesis	hypothesis	NOUN
bam-14214	113	9	that	that	DET
bam-14214	113	10	brief	brief	ADJ
bam-14214	113	11	,	,	PUNCT
bam-14214	113	12	early	early	ADJ
bam-14214	113	13	-	-	PUNCT
bam-14214	113	14	life	life	NOUN
bam-14214	113	15	exercise	exercise	NOUN
bam-14214	113	16	or	or	CCONJ
bam-14214	113	17	irisin	irisin	VERB
bam-14214	113	18	treatment	treatment	NOUN
bam-14214	113	19	may	may	AUX
bam-14214	113	20	enhance	enhance	VERB
bam-14214	113	21	longevity	longevity	NOUN
bam-14214	113	22	potential	potential	NOUN
bam-14214	113	23	by	by	ADP
bam-14214	113	24	initiating	initiate	VERB
bam-14214	113	25	protective	protective	ADJ
bam-14214	113	26	molecular	molecular	ADJ
bam-14214	113	27	programs	program	NOUN
bam-14214	113	28	,	,	PUNCT
bam-14214	113	29	particularly	particularly	ADV
bam-14214	113	30	in	in	ADP
bam-14214	113	31	tissues	tissue	NOUN
bam-14214	113	32	like	like	ADP
bam-14214	113	33	the	the	DET
bam-14214	113	34	kidney	kidney	NOUN
bam-14214	113	35	,	,	PUNCT
bam-14214	113	36	where	where	SCONJ
bam-14214	113	37	klotho	klotho	VERB
bam-14214	113	38	expression	expression	NOUN
bam-14214	113	39	is	be	AUX
bam-14214	113	40	pivotal	pivotal	ADJ
bam-14214	113	41	.	.	PUNCT
bam-14214	114	1	these	these	DET
bam-14214	114	2	preliminary	preliminary	ADJ
bam-14214	114	3	findings	finding	NOUN
bam-14214	114	4	warrant	warrant	VERB
bam-14214	114	5	further	further	ADJ
bam-14214	114	6	investigation	investigation	NOUN
bam-14214	114	7	in	in	ADP
bam-14214	114	8	aged	aged	ADJ
bam-14214	114	9	or	or	CCONJ
bam-14214	114	10	disease	disease	NOUN
bam-14214	114	11	-	-	PUNCT
bam-14214	114	12	prone	prone	ADJ
bam-14214	114	13	models	model	NOUN
bam-14214	114	14	and	and	CCONJ
bam-14214	114	15	raise	raise	VERB
bam-14214	114	16	the	the	DET
bam-14214	114	17	prospect	prospect	NOUN
bam-14214	114	18	of	of	ADP
bam-14214	114	19	developing	develop	VERB
bam-14214	114	20	early	early	ADJ
bam-14214	114	21	-	-	PUNCT
bam-14214	114	22	life	life	NOUN
bam-14214	114	23	or	or	CCONJ
bam-14214	114	24	onetime	onetime	ADJ
bam-14214	114	25	exercise	exercise	NOUN
bam-14214	114	26	-	-	PUNCT
bam-14214	114	27	mimetic	mimetic	ADJ
bam-14214	114	28	interventions	intervention	NOUN
bam-14214	114	29	to	to	PART
bam-14214	114	30	promote	promote	VERB
bam-14214	114	31	healthy	healthy	ADJ
bam-14214	114	32	aging	age	VERB
bam-14214	114	33	trajectories	trajectory	NOUN
bam-14214	114	34	.	.	PUNCT
bam-14214	115	1	conclusions	conclusion	NOUN
bam-14214	115	2	this	this	DET
bam-14214	115	3	study	study	NOUN
bam-14214	115	4	provides	provide	VERB
bam-14214	115	5	compelling	compelling	ADJ
bam-14214	115	6	evidence	evidence	NOUN
bam-14214	115	7	that	that	SCONJ
bam-14214	115	8	both	both	DET
bam-14214	115	9	physical	physical	ADJ
bam-14214	115	10	exercise	exercise	NOUN
bam-14214	115	11	,	,	PUNCT
bam-14214	115	12	particularly	particularly	ADV
bam-14214	115	13	resistance	resistance	NOUN
bam-14214	115	14	training	training	NOUN
bam-14214	115	15	and	and	CCONJ
bam-14214	115	16	exogenous	exogenous	ADJ
bam-14214	115	17	irisin	irisin	NOUN
bam-14214	115	18	administration	administration	NOUN
bam-14214	115	19	can	can	AUX
bam-14214	115	20	significantly	significantly	ADV
bam-14214	115	21	upregulate	upregulate	VERB
bam-14214	115	22	the	the	DET
bam-14214	115	23	renal	renal	ADJ
bam-14214	115	24	expression	expression	NOUN
bam-14214	115	25	of	of	ADP
bam-14214	115	26	klotho	klotho	PROPN
bam-14214	115	27	and	and	CCONJ
bam-14214	115	28	hsp70	hsp70	NOUN
bam-14214	115	29	,	,	PUNCT
bam-14214	115	30	two	two	NUM
bam-14214	115	31	critical	critical	ADJ
bam-14214	115	32	regulators	regulator	NOUN
bam-14214	115	33	of	of	ADP
bam-14214	115	34	cellular	cellular	ADJ
bam-14214	115	35	stress	stress	NOUN
bam-14214	115	36	resistance	resistance	NOUN
bam-14214	115	37	and	and	CCONJ
bam-14214	115	38	longevity	longevity	NOUN
bam-14214	115	39	.	.	PUNCT
bam-14214	116	1	our	our	PRON
bam-14214	116	2	findings	finding	NOUN
bam-14214	116	3	demonstrate	demonstrate	VERB
bam-14214	116	4	that	that	SCONJ
bam-14214	116	5	early	early	ADJ
bam-14214	116	6	-	-	PUNCT
bam-14214	116	7	life	life	NOUN
bam-14214	116	8	interventions	intervention	NOUN
bam-14214	116	9	not	not	PART
bam-14214	116	10	only	only	ADV
bam-14214	116	11	induce	induce	VERB
bam-14214	116	12	favorable	favorable	ADJ
bam-14214	116	13	molecular	molecular	ADJ
bam-14214	116	14	adaptations	adaptation	NOUN
bam-14214	116	15	but	but	CCONJ
bam-14214	116	16	may	may	AUX
bam-14214	116	17	also	also	ADV
bam-14214	116	18	confer	confer	VERB
bam-14214	116	19	long	long	ADJ
bam-14214	116	20	-	-	PUNCT
bam-14214	116	21	term	term	NOUN
bam-14214	116	22	survival	survival	NOUN
bam-14214	116	23	benefits	benefit	NOUN
bam-14214	116	24	,	,	PUNCT
bam-14214	116	25	even	even	ADV
bam-14214	116	26	in	in	ADP
bam-14214	116	27	the	the	DET
bam-14214	116	28	absence	absence	NOUN
bam-14214	116	29	of	of	ADP
bam-14214	116	30	continuous	continuous	ADJ
bam-14214	116	31	stimulation	stimulation	NOUN
bam-14214	116	32	.	.	PUNCT
bam-14214	117	1	notably	notably	ADV
bam-14214	117	2	,	,	PUNCT
bam-14214	117	3	irisin	irisin	VERB
bam-14214	117	4	mimicked	mimic	VERB
bam-14214	117	5	many	many	ADJ
bam-14214	117	6	of	of	ADP
bam-14214	117	7	the	the	DET
bam-14214	117	8	beneficial	beneficial	ADJ
bam-14214	117	9	effects	effect	NOUN
bam-14214	117	10	of	of	ADP
bam-14214	117	11	exercise	exercise	NOUN
bam-14214	117	12	,	,	PUNCT
bam-14214	117	13	supporting	support	VERB
bam-14214	117	14	its	its	PRON
bam-14214	117	15	potential	potential	NOUN
bam-14214	117	16	as	as	ADP
bam-14214	117	17	a	a	DET
bam-14214	117	18	promising	promising	ADJ
bam-14214	117	19	exercise	exercise	NOUN
bam-14214	117	20	-	-	PUNCT
bam-14214	117	21	mimetic	mimetic	ADJ
bam-14214	117	22	candidate	candidate	NOUN
bam-14214	117	23	for	for	ADP
bam-14214	117	24	populations	population	NOUN
bam-14214	117	25	unable	unable	ADJ
bam-14214	117	26	to	to	PART
bam-14214	117	27	engage	engage	VERB
bam-14214	117	28	in	in	ADP
bam-14214	117	29	physical	physical	ADJ
bam-14214	117	30	activity	activity	NOUN
bam-14214	117	31	.	.	PUNCT
bam-14214	118	1	although	although	SCONJ
bam-14214	118	2	the	the	DET
bam-14214	118	3	survival	survival	NOUN
bam-14214	118	4	analysis	analysis	NOUN
bam-14214	118	5	did	do	AUX
bam-14214	118	6	not	not	PART
bam-14214	118	7	yield	yield	VERB
bam-14214	118	8	statistically	statistically	ADV
bam-14214	118	9	significant	significant	ADJ
bam-14214	118	10	differences	difference	NOUN
bam-14214	118	11	across	across	ADP
bam-14214	118	12	all	all	DET
bam-14214	118	13	tests	test	NOUN
bam-14214	118	14	,	,	PUNCT
bam-14214	118	15	a	a	DET
bam-14214	118	16	meaningful	meaningful	ADJ
bam-14214	118	17	trend	trend	NOUN
bam-14214	118	18	toward	toward	ADP
bam-14214	118	19	improved	improved	ADJ
bam-14214	118	20	survival	survival	NOUN
bam-14214	118	21	in	in	ADP
bam-14214	118	22	the	the	DET
bam-14214	118	23	intervention	intervention	NOUN
bam-14214	118	24	groups	group	NOUN
bam-14214	118	25	was	be	AUX
bam-14214	118	26	observed	observe	VERB
bam-14214	118	27	,	,	PUNCT
bam-14214	118	28	reinforcing	reinforce	VERB
bam-14214	118	29	the	the	DET
bam-14214	118	30	hypothesis	hypothesis	NOUN
bam-14214	118	31	that	that	PRON
bam-14214	118	32	early	early	ADJ
bam-14214	118	33	-	-	PUNCT
bam-14214	118	34	life	life	NOUN
bam-14214	118	35	molecular	molecular	ADJ
bam-14214	118	36	enhancement	enhancement	NOUN
bam-14214	118	37	may	may	AUX
bam-14214	118	38	promote	promote	VERB
bam-14214	118	39	physiological	physiological	ADJ
bam-14214	118	40	resilience	resilience	NOUN
bam-14214	118	41	during	during	ADP
bam-14214	118	42	aging	aging	NOUN
bam-14214	118	43	.	.	PUNCT
bam-14214	119	1	these	these	DET
bam-14214	119	2	findings	finding	NOUN
bam-14214	119	3	highlight	highlight	VERB
bam-14214	119	4	the	the	DET
bam-14214	119	5	translational	translational	ADJ
bam-14214	119	6	potential	potential	NOUN
bam-14214	119	7	of	of	ADP
bam-14214	119	8	muscle	muscle	NOUN
bam-14214	119	9	-	-	PUNCT
bam-14214	119	10	derived	derive	VERB
bam-14214	119	11	signaling	signal	VERB
bam-14214	119	12	molecules	molecule	NOUN
bam-14214	119	13	like	like	ADP
bam-14214	119	14	irisin	irisin	NOUN
bam-14214	119	15	in	in	ADP
bam-14214	119	16	targeting	target	VERB
bam-14214	119	17	systemic	systemic	ADJ
bam-14214	119	18	aging	age	VERB
bam-14214	119	19	pathways	pathway	NOUN
bam-14214	119	20	.	.	PUNCT
bam-14214	120	1	future	future	ADJ
bam-14214	120	2	studies	study	NOUN
bam-14214	120	3	using	use	VERB
bam-14214	120	4	aged	aged	ADJ
bam-14214	120	5	or	or	CCONJ
bam-14214	120	6	disease	disease	NOUN
bam-14214	120	7	-	-	PUNCT
bam-14214	120	8	prone	prone	ADJ
bam-14214	120	9	models	model	NOUN
bam-14214	120	10	,	,	PUNCT
bam-14214	120	11	as	as	ADV
bam-14214	120	12	well	well	ADV
bam-14214	120	13	as	as	ADP
bam-14214	120	14	investigations	investigation	NOUN
bam-14214	120	15	into	into	ADP
bam-14214	120	16	tissue	tissue	NOUN
bam-14214	120	17	-	-	PUNCT
bam-14214	120	18	specific	specific	ADJ
bam-14214	120	19	effects	effect	NOUN
bam-14214	120	20	beyond	beyond	ADP
bam-14214	120	21	the	the	DET
bam-14214	120	22	kidney	kidney	NOUN
bam-14214	120	23	,	,	PUNCT
bam-14214	120	24	will	will	AUX
bam-14214	120	25	be	be	AUX
bam-14214	120	26	essential	essential	ADJ
bam-14214	120	27	to	to	PART
bam-14214	120	28	fully	fully	ADV
bam-14214	120	29	elucidate	elucidate	VERB
bam-14214	120	30	the	the	DET
bam-14214	120	31	therapeutic	therapeutic	ADJ
bam-14214	120	32	potential	potential	NOUN
bam-14214	120	33	of	of	ADP
bam-14214	120	34	irisin	irisin	NOUN
bam-14214	120	35	and	and	CCONJ
bam-14214	120	36	refine	refine	VERB
bam-14214	120	37	strategies	strategy	NOUN
bam-14214	120	38	for	for	ADP
bam-14214	120	39	delaying	delay	VERB
bam-14214	120	40	age	age	NOUN
bam-14214	120	41	-	-	PUNCT
bam-14214	120	42	related	relate	VERB
bam-14214	120	43	decline	decline	NOUN
bam-14214	120	44	.	.	PUNCT
bam-14214	121	1	overall	overall	ADV
bam-14214	121	2	,	,	PUNCT
bam-14214	121	3	our	our	PRON
bam-14214	121	4	work	work	NOUN
bam-14214	121	5	adds	add	VERB
bam-14214	121	6	to	to	ADP
bam-14214	121	7	the	the	DET
bam-14214	121	8	growing	grow	VERB
bam-14214	121	9	body	body	NOUN
bam-14214	121	10	of	of	ADP
bam-14214	121	11	evidence	evidence	NOUN
bam-14214	121	12	that	that	SCONJ
bam-14214	121	13	skeletal	skeletal	ADJ
bam-14214	121	14	muscle	muscle	NOUN
bam-14214	121	15	exerts	exert	VERB
bam-14214	121	16	far	far	ADV
bam-14214	121	17	-	-	PUNCT
bam-14214	121	18	reaching	reach	VERB
bam-14214	121	19	endocrine	endocrine	NOUN
bam-14214	121	20	effects	effect	NOUN
bam-14214	121	21	with	with	ADP
bam-14214	121	22	implications	implication	NOUN
bam-14214	121	23	for	for	ADP
bam-14214	121	24	aging	age	VERB
bam-14214	121	25	,	,	PUNCT
bam-14214	121	26	renal	renal	ADJ
bam-14214	121	27	health	health	NOUN
bam-14214	121	28	,	,	PUNCT
bam-14214	121	29	and	and	CCONJ
bam-14214	121	30	systemic	systemic	ADJ
bam-14214	121	31	homeostasis	homeostasis	NOUN
bam-14214	121	32	.	.	PUNCT
bam-14214	122	1	corresponding	correspond	VERB
bam-14214	122	2	author	author	NOUN
bam-14214	122	3	12	12	NUM
bam-14214	122	4	saeed	saeed	PROPN
bam-14214	122	5	zamani	zamani	PROPN
bam-14214	122	6	,	,	PUNCT
bam-14214	122	7	department	department	NOUN
bam-14214	122	8	of	of	ADP
bam-14214	122	9	anatomical	anatomical	ADJ
bam-14214	122	10	sciences	science	NOUN
bam-14214	122	11	,	,	PUNCT
bam-14214	122	12	school	school	NOUN
bam-14214	122	13	of	of	ADP
bam-14214	122	14	medicine	medicine	NOUN
bam-14214	122	15	,	,	PUNCT
bam-14214	122	16	isfahan	isfahan	PROPN
bam-14214	122	17	university	university	PROPN
bam-14214	122	18	of	of	ADP
bam-14214	122	19	medical	medical	ADJ
bam-14214	122	20	sciences	sciences	PROPN
bam-14214	122	21	,	,	PUNCT
bam-14214	122	22	isfahan	isfahan	NOUN
bam-14214	122	23	,	,	PUNCT
bam-14214	122	24	iran	iran	PROPN
bam-14214	122	25	tel	tel	PROPN
bam-14214	122	26	.	.	PUNCT
bam-14214	122	27	:	:	PUNCT
bam-14214	123	1	+98.9132662575	+98.9132662575	PROPN
bam-14214	123	2	fax	fax	NOUN
bam-14214	123	3	:	:	PUNCT
bam-14214	123	4	+98.3137929158	+98.3137929158	PROPN
bam-14214	123	5	saeed.zamani@med.mui.ac.ir	saeed.zamani@med.mui.ac.ir	VERB
bam-14214	123	6	0000	0000	NUM
bam-14214	123	7	-	-	PUNCT
bam-14214	123	8	0002	0002	NUM
bam-14214	123	9	-	-	PUNCT
bam-14214	123	10	0112	0112	NUM
bam-14214	123	11	-	-	PUNCT
bam-14214	123	12	2267	2267	NUM
bam-14214	123	13	zahra	zahra	NOUN
bam-14214	123	14	sadat	sadat	PROPN
bam-14214	123	15	aghili	aghili	PROPN
bam-14214	123	16	0000	0000	NUM
bam-14214	123	17	-	-	PUNCT
bam-14214	123	18	0001	0001	NUM
bam-14214	123	19	-	-	PUNCT
bam-14214	123	20	5022	5022	NUM
bam-14214	123	21	-	-	SYM
bam-14214	123	22	2224	2224	NUM
bam-14214	123	23	z.s.aghili@gmail.com	z.s.aghili@gmail.com	X
bam-14214	124	1	mansour	mansour	PROPN
bam-14214	124	2	homayoun	homayoun	PROPN
bam-14214	124	3	0000	0000	NUM
bam-14214	124	4	-	-	SYM
bam-14214	124	5	0003	0003	NUM
bam-14214	124	6	-	-	PUNCT
bam-14214	124	7	1676	1676	NUM
bam-14214	124	8	-	-	SYM
bam-14214	124	9	3443	3443	NUM
bam-14214	124	10	homayoun.m@med.mui.ac.ir	homayoun.m@med.mui.ac.ir	PROPN
bam-14214	124	11	hossein	hossein	PROPN
bam-14214	124	12	rezazadeh	rezazadeh	PROPN
bam-14214	124	13	0000	0000	NUM
bam-14214	124	14	-	-	PUNCT
bam-14214	124	15	0003	0003	NUM
bam-14214	124	16	-	-	PUNCT
bam-14214	124	17	0831	0831	NUM
bam-14214	124	18	-	-	PUNCT
bam-14214	124	19	6811	6811	NUM
bam-14214	124	20	h.rezazadeh@med.mui.ac.ir	h.rezazadeh@med.mui.ac.ir	PROPN
bam-14214	124	21	funding	funding	NOUN
bam-14214	124	22	this	this	DET
bam-14214	124	23	study	study	NOUN
bam-14214	124	24	was	be	AUX
bam-14214	124	25	supported	support	VERB
bam-14214	124	26	by	by	ADP
bam-14214	124	27	isfahan	isfahan	PROPN
bam-14214	124	28	university	university	PROPN
bam-14214	124	29	of	of	ADP
bam-14214	124	30	medical	medical	ADJ
bam-14214	124	31	science	science	NOUN
bam-14214	124	32	(	(	PUNCT
bam-14214	124	33	grant	grant	PROPN
bam-14214	124	34	number	number	NOUN
bam-14214	124	35	:	:	PUNCT
bam-14214	124	36	1400465	1400465	NUM
bam-14214	124	37	)	)	PUNCT
bam-14214	124	38	.	.	PUNCT
bam-14214	125	1	the	the	DET
bam-14214	125	2	funding	funding	NOUN
bam-14214	125	3	body	body	NOUN
bam-14214	125	4	had	have	VERB
bam-14214	125	5	no	no	DET
bam-14214	125	6	role	role	NOUN
bam-14214	125	7	in	in	ADP
bam-14214	125	8	the	the	DET
bam-14214	125	9	design	design	NOUN
bam-14214	125	10	of	of	ADP
bam-14214	125	11	the	the	DET
bam-14214	125	12	study	study	NOUN
bam-14214	125	13	,	,	PUNCT
bam-14214	125	14	collection	collection	NOUN
bam-14214	125	15	,	,	PUNCT
bam-14214	125	16	analysis	analysis	NOUN
bam-14214	125	17	,	,	PUNCT
bam-14214	125	18	or	or	CCONJ
bam-14214	125	19	interpretation	interpretation	NOUN
bam-14214	125	20	of	of	ADP
bam-14214	125	21	data	datum	NOUN
bam-14214	125	22	,	,	PUNCT
bam-14214	125	23	or	or	CCONJ
bam-14214	125	24	in	in	ADP
bam-14214	125	25	writing	write	VERB
bam-14214	125	26	the	the	DET
bam-14214	125	27	manuscript	manuscript	NOUN
bam-14214	125	28	.	.	PUNCT
bam-14214	126	1	e	e	X
bam-14214	126	2	-	-	NOUN
bam-14214	126	3	publishing	publishing	NOUN
bam-14214	126	4	of	of	ADP
bam-14214	126	5	this	this	DET
bam-14214	126	6	typescript	typescript	NOUN
bam-14214	126	7	was	be	AUX
bam-14214	126	8	supported	support	VERB
bam-14214	126	9	by	by	ADP
bam-14214	126	10	the	the	DET
bam-14214	126	11	armando	armando	PROPN
bam-14214	126	12	&	&	CCONJ
bam-14214	126	13	carmela	carmela	PROPN
bam-14214	126	14	mioni	mioni	PROPN
bam-14214	126	15	-	-	PUNCT
bam-14214	126	16	carraro	carraro	NOUN
bam-14214	126	17	foundation	foundation	NOUN
bam-14214	126	18	for	for	ADP
bam-14214	126	19	translational	translational	ADJ
bam-14214	126	20	myology	myology	NOUN
bam-14214	126	21	,	,	PUNCT
bam-14214	126	22	galleria	galleria	PROPN
bam-14214	126	23	duomo	duomo	PROPN
bam-14214	126	24	5	5	NUM
bam-14214	126	25	,	,	PUNCT
bam-14214	126	26	35141	35141	NUM
bam-14214	126	27	padua	padua	NOUN
bam-14214	126	28	,	,	PUNCT
bam-14214	126	29	italy	italy	PROPN
bam-14214	126	30	,	,	PUNCT
bam-14214	126	31	and	and	CCONJ
bam-14214	126	32	pagepress	pagepress	NOUN
bam-14214	126	33	publications	publication	NOUN
bam-14214	126	34	,	,	PUNCT
bam-14214	126	35	via	via	ADP
bam-14214	126	36	a.	a.	PROPN
bam-14214	126	37	cavagna	cavagna	PROPN
bam-14214	126	38	sangiuliani	sangiuliani	PROPN
bam-14214	126	39	5	5	NUM
bam-14214	126	40	,	,	PUNCT
bam-14214	126	41	27100	27100	NUM
bam-14214	126	42	pavia	pavia	NOUN
bam-14214	126	43	,	,	PUNCT
bam-14214	126	44	italy	italy	PROPN
bam-14214	126	45	13	13	NUM
bam-14214	126	46	conflicts	conflict	NOUN
bam-14214	126	47	of	of	ADP
bam-14214	126	48	interest	interest	NOUN
bam-14214	126	49	the	the	DET
bam-14214	126	50	authors	author	NOUN
bam-14214	126	51	declare	declare	VERB
bam-14214	126	52	that	that	SCONJ
bam-14214	126	53	they	they	PRON
bam-14214	126	54	have	have	VERB
bam-14214	126	55	no	no	DET
bam-14214	126	56	conflicts	conflict	NOUN
bam-14214	126	57	of	of	ADP
bam-14214	126	58	interest	interest	NOUN
bam-14214	126	59	to	to	PART
bam-14214	126	60	disclose	disclose	VERB
bam-14214	126	61	.	.	PUNCT
bam-14214	127	1	contributions	contribution	NOUN
bam-14214	127	2	zsa	zsa	PROPN
bam-14214	127	3	,	,	PUNCT
bam-14214	127	4	conceptualization	conceptualization	NOUN
bam-14214	127	5	,	,	PUNCT
bam-14214	127	6	methodology	methodology	NOUN
bam-14214	127	7	,	,	PUNCT
bam-14214	127	8	investigation	investigation	NOUN
bam-14214	127	9	,	,	PUNCT
bam-14214	127	10	data	data	NOUN
bam-14214	127	11	curation	curation	NOUN
bam-14214	127	12	,	,	PUNCT
bam-14214	127	13	writing	write	VERB
bam-14214	127	14	–	–	PUNCT
bam-14214	127	15	original	original	ADJ
bam-14214	127	16	draft	draft	NOUN
bam-14214	127	17	;	;	PUNCT
bam-14214	127	18	mh	mh	PROPN
bam-14214	127	19	,	,	PUNCT
bam-14214	127	20	methodology	methodology	NOUN
bam-14214	127	21	,	,	PUNCT
bam-14214	127	22	investigation	investigation	NOUN
bam-14214	127	23	,	,	PUNCT
bam-14214	127	24	formal	formal	ADJ
bam-14214	127	25	analysis	analysis	NOUN
bam-14214	127	26	;	;	PUNCT
bam-14214	127	27	hr	hr	NOUN
bam-14214	127	28	,	,	PUNCT
bam-14214	127	29	validation	validation	NOUN
bam-14214	127	30	,	,	PUNCT
bam-14214	127	31	resources	resource	NOUN
bam-14214	127	32	,	,	PUNCT
bam-14214	127	33	writing	writing	NOUN
bam-14214	127	34	–	–	PUNCT
bam-14214	127	35	review	review	NOUN
bam-14214	127	36	&	&	CCONJ
bam-14214	127	37	editing	editing	NOUN
bam-14214	127	38	;	;	PUNCT
bam-14214	127	39	sz	sz	NOUN
bam-14214	127	40	,	,	PUNCT
bam-14214	127	41	conceptualization	conceptualization	NOUN
bam-14214	127	42	,	,	PUNCT
bam-14214	127	43	methodology	methodology	NOUN
bam-14214	127	44	,	,	PUNCT
bam-14214	127	45	supervision	supervision	NOUN
bam-14214	127	46	,	,	PUNCT
bam-14214	127	47	project	project	NOUN
bam-14214	127	48	administration	administration	NOUN
bam-14214	127	49	,	,	PUNCT
bam-14214	127	50	funding	funding	NOUN
bam-14214	127	51	acquisition	acquisition	NOUN
bam-14214	127	52	.	.	PUNCT
bam-14214	128	1	all	all	DET
bam-14214	128	2	authors	author	NOUN
bam-14214	128	3	read	read	VERB
bam-14214	128	4	and	and	CCONJ
bam-14214	128	5	approved	approve	VERB
bam-14214	128	6	the	the	DET
bam-14214	128	7	final	final	ADJ
bam-14214	128	8	manuscript	manuscript	NOUN
bam-14214	128	9	.	.	PUNCT
bam-14214	129	1	ethics	ethic	NOUN
bam-14214	129	2	approval	approval	VERB
bam-14214	129	3	all	all	DET
bam-14214	129	4	experimental	experimental	ADJ
bam-14214	129	5	procedures	procedure	NOUN
bam-14214	129	6	involving	involve	VERB
bam-14214	129	7	animals	animal	NOUN
bam-14214	129	8	were	be	AUX
bam-14214	129	9	conducted	conduct	VERB
bam-14214	129	10	in	in	ADP
bam-14214	129	11	accordance	accordance	NOUN
bam-14214	129	12	with	with	ADP
bam-14214	129	13	the	the	DET
bam-14214	129	14	guide	guide	NOUN
bam-14214	129	15	for	for	ADP
bam-14214	129	16	the	the	DET
bam-14214	129	17	care	care	NOUN
bam-14214	129	18	and	and	CCONJ
bam-14214	129	19	use	use	NOUN
bam-14214	129	20	of	of	ADP
bam-14214	129	21	laboratory	laboratory	NOUN
bam-14214	129	22	animals	animal	NOUN
bam-14214	129	23	(	(	PUNCT
bam-14214	129	24	national	national	PROPN
bam-14214	129	25	research	research	PROPN
bam-14214	129	26	council	council	PROPN
bam-14214	129	27	,	,	PUNCT
bam-14214	129	28	usa	usa	PROPN
bam-14214	129	29	)	)	PUNCT
bam-14214	129	30	and	and	CCONJ
bam-14214	129	31	were	be	AUX
bam-14214	129	32	approved	approve	VERB
bam-14214	129	33	by	by	ADP
bam-14214	129	34	the	the	DET
bam-14214	129	35	institutional	institutional	ADJ
bam-14214	129	36	animal	animal	NOUN
bam-14214	129	37	care	care	NOUN
bam-14214	129	38	and	and	CCONJ
bam-14214	129	39	use	use	VERB
bam-14214	129	40	committee	committee	NOUN
bam-14214	129	41	(	(	PUNCT
bam-14214	129	42	iacuc	iacuc	NOUN
bam-14214	129	43	)	)	PUNCT
bam-14214	129	44	of	of	ADP
bam-14214	129	45	by	by	ADP
bam-14214	129	46	isfahan	isfahan	PROPN
bam-14214	129	47	university	university	PROPN
bam-14214	129	48	of	of	ADP
bam-14214	129	49	medical	medical	ADJ
bam-14214	129	50	science	science	NOUN
bam-14214	129	51	(	(	PUNCT
bam-14214	129	52	approval	approval	NOUN
bam-14214	129	53	code	code	NOUN
bam-14214	129	54	:	:	PUNCT
bam-14214	129	55	ir.mui.med.rec.1401.024	ir.mui.med.rec.1401.024	NUM
bam-14214	129	56	)	)	PUNCT
bam-14214	129	57	.	.	PUNCT
bam-14214	130	1	all	all	DET
bam-14214	130	2	efforts	effort	NOUN
bam-14214	130	3	were	be	AUX
bam-14214	130	4	made	make	VERB
bam-14214	130	5	to	to	PART
bam-14214	130	6	minimize	minimize	VERB
bam-14214	130	7	animal	animal	NOUN
bam-14214	130	8	suffering	suffering	NOUN
bam-14214	130	9	and	and	CCONJ
bam-14214	130	10	to	to	PART
bam-14214	130	11	reduce	reduce	VERB
bam-14214	130	12	the	the	DET
bam-14214	130	13	number	number	NOUN
bam-14214	130	14	of	of	ADP
bam-14214	130	15	animals	animal	NOUN
bam-14214	130	16	used	use	VERB
bam-14214	130	17	.	.	PUNCT
bam-14214	131	1	informed	informed	ADJ
bam-14214	131	2	consent	consent	NOUN
bam-14214	131	3	not	not	PART
bam-14214	131	4	applicable	applicable	ADJ
bam-14214	131	5	.	.	PUNCT
bam-14214	132	1	data	datum	NOUN
bam-14214	132	2	availability	availability	NOUN
bam-14214	132	3	the	the	DET
bam-14214	132	4	datasets	dataset	NOUN
bam-14214	132	5	generated	generate	VERB
bam-14214	132	6	and	and	CCONJ
bam-14214	132	7	analyzed	analyze	VERB
bam-14214	132	8	during	during	ADP
bam-14214	132	9	the	the	DET
bam-14214	132	10	current	current	ADJ
bam-14214	132	11	study	study	NOUN
bam-14214	132	12	are	be	AUX
bam-14214	132	13	available	available	ADJ
bam-14214	132	14	from	from	ADP
bam-14214	132	15	the	the	DET
bam-14214	132	16	corresponding	corresponding	ADJ
bam-14214	132	17	author	author	NOUN
bam-14214	132	18	upon	upon	SCONJ
bam-14214	132	19	reasonable	reasonable	ADJ
bam-14214	132	20	request	request	NOUN
bam-14214	132	21	.	.	PUNCT
bam-14214	133	1	acknowledgements	acknowledgement	NOUN
bam-14214	133	2	the	the	DET
bam-14214	133	3	authors	author	NOUN
bam-14214	133	4	would	would	AUX
bam-14214	133	5	like	like	VERB
bam-14214	133	6	to	to	PART
bam-14214	133	7	thank	thank	VERB
bam-14214	133	8	isfahan	isfahan	PROPN
bam-14214	133	9	university	university	PROPN
bam-14214	133	10	of	of	ADP
bam-14214	133	11	medical	medical	ADJ
bam-14214	133	12	science	science	NOUN
bam-14214	133	13	,	,	PUNCT
bam-14214	133	14	for	for	ADP
bam-14214	133	15	their	their	PRON
bam-14214	133	16	technical	technical	ADJ
bam-14214	133	17	support	support	NOUN
bam-14214	133	18	and	and	CCONJ
bam-14214	133	19	assistance	assistance	NOUN
bam-14214	133	20	during	during	ADP
bam-14214	133	21	the	the	DET
bam-14214	133	22	study	study	NOUN
bam-14214	133	23	.	.	PUNCT
bam-14214	134	1	14	14	NUM
bam-14214	134	2	referenses	referense	NOUN
bam-14214	134	3	1	1	NUM
bam-14214	134	4	.	.	PUNCT
bam-14214	134	5	tenchov	tenchov	PROPN
bam-14214	134	6	r	r	PROPN
bam-14214	134	7	,	,	PUNCT
bam-14214	134	8	sasso	sasso	PROPN
bam-14214	134	9	jm	jm	PROPN
bam-14214	134	10	,	,	PUNCT
bam-14214	134	11	wang	wang	PROPN
bam-14214	134	12	x	x	PROPN
bam-14214	134	13	,	,	PUNCT
bam-14214	134	14	zhou	zhou	PROPN
bam-14214	134	15	qa	qa	PROPN
bam-14214	134	16	.	.	PUNCT
bam-14214	135	1	aging	age	VERB
bam-14214	135	2	hallmarks	hallmark	NOUN
bam-14214	135	3	and	and	CCONJ
bam-14214	135	4	progression	progression	NOUN
bam-14214	135	5	and	and	CCONJ
bam-14214	135	6	age	age	NOUN
bam-14214	135	7	-	-	PUNCT
bam-14214	135	8	related	relate	VERB
bam-14214	135	9	diseases	disease	NOUN
bam-14214	135	10	:	:	PUNCT
bam-14214	135	11	a	a	DET
bam-14214	135	12	landscape	landscape	NOUN
bam-14214	135	13	view	view	NOUN
bam-14214	135	14	of	of	ADP
bam-14214	135	15	research	research	NOUN
bam-14214	135	16	advancement	advancement	NOUN
bam-14214	135	17	.	.	PUNCT
bam-14214	136	1	acs	acs	PROPN
bam-14214	136	2	chem	chem	NOUN
bam-14214	136	3	neurosci	neurosci	NOUN
bam-14214	136	4	2023;15:1	2023;15:1	NUM
bam-14214	136	5	-	-	SYM
bam-14214	136	6	30	30	NUM
bam-14214	136	7	.	.	PUNCT
bam-14214	137	1	2	2	X
bam-14214	137	2	.	.	X
bam-14214	137	3	lópez	lópez	NOUN
bam-14214	137	4	-	-	PUNCT
bam-14214	137	5	otín	otín	PROPN
bam-14214	137	6	c	c	PROPN
bam-14214	137	7	,	,	PUNCT
bam-14214	137	8	blasco	blasco	PROPN
bam-14214	137	9	ma	ma	PROPN
bam-14214	137	10	,	,	PUNCT
bam-14214	137	11	partridge	partridge	NOUN
bam-14214	137	12	l	l	PROPN
bam-14214	137	13	,	,	PUNCT
bam-14214	137	14	et	et	PROPN
bam-14214	137	15	al	al	PROPN
bam-14214	137	16	.	.	PUNCT
bam-14214	138	1	the	the	DET
bam-14214	138	2	hallmarks	hallmark	NOUN
bam-14214	138	3	of	of	ADP
bam-14214	138	4	aging	aging	NOUN
bam-14214	138	5	.	.	PUNCT
bam-14214	139	1	cell	cell	NOUN
bam-14214	139	2	2013;153:1194217	2013;153:1194217	NUM
bam-14214	139	3	.	.	PUNCT
bam-14214	140	1	3	3	X
bam-14214	140	2	.	.	X
bam-14214	140	3	guo	guo	PROPN
bam-14214	140	4	j	j	PROPN
bam-14214	140	5	,	,	PUNCT
bam-14214	140	6	huang	huang	PROPN
bam-14214	140	7	x	x	PROPN
bam-14214	140	8	,	,	PUNCT
bam-14214	140	9	dou	dou	PROPN
bam-14214	140	10	l	l	NOUN
bam-14214	140	11	,	,	PUNCT
bam-14214	140	12	et	et	PROPN
bam-14214	140	13	al	al	PROPN
bam-14214	140	14	.	.	PROPN
bam-14214	140	15	aging	age	VERB
bam-14214	140	16	and	and	CCONJ
bam-14214	140	17	aging	age	VERB
bam-14214	140	18	-	-	PUNCT
bam-14214	140	19	related	relate	VERB
bam-14214	140	20	diseases	disease	NOUN
bam-14214	140	21	:	:	PUNCT
bam-14214	140	22	from	from	ADP
bam-14214	140	23	molecular	molecular	ADJ
bam-14214	140	24	mechanisms	mechanism	NOUN
bam-14214	140	25	to	to	ADP
bam-14214	140	26	interventions	intervention	NOUN
bam-14214	140	27	and	and	CCONJ
bam-14214	140	28	treatments	treatment	NOUN
bam-14214	140	29	.	.	PUNCT
bam-14214	141	1	signal	signal	PROPN
bam-14214	141	2	transduct	transduct	NOUN
bam-14214	141	3	target	target	NOUN
bam-14214	141	4	ther	ther	NOUN
bam-14214	141	5	2022;7:391	2022;7:391	NUM
bam-14214	141	6	.	.	PUNCT
bam-14214	142	1	4	4	NUM
bam-14214	142	2	.	.	X
bam-14214	142	3	xu	xu	PROPN
bam-14214	143	1	y	y	PROPN
bam-14214	143	2	,	,	PUNCT
bam-14214	143	3	sun	sun	PROPN
bam-14214	143	4	z.	z.	PROPN
bam-14214	143	5	molecular	molecular	ADJ
bam-14214	143	6	basis	basis	NOUN
bam-14214	143	7	of	of	ADP
bam-14214	143	8	klotho	klotho	NOUN
bam-14214	143	9	:	:	PUNCT
bam-14214	143	10	from	from	ADP
bam-14214	143	11	gene	gene	NOUN
bam-14214	143	12	to	to	PART
bam-14214	143	13	function	function	VERB
bam-14214	143	14	in	in	ADP
bam-14214	143	15	aging	aging	NOUN
bam-14214	143	16	.	.	PUNCT
bam-14214	144	1	endocr	endocr	PROPN
bam-14214	144	2	rev	rev	PROPN
bam-14214	144	3	2015;36:174	2015;36:174	PROPN
bam-14214	144	4	-	-	SYM
bam-14214	144	5	93	93	NUM
bam-14214	144	6	.	.	PUNCT
bam-14214	145	1	5	5	X
bam-14214	145	2	.	.	X
bam-14214	145	3	kuro	kuro	NOUN
bam-14214	145	4	-	-	PUNCT
bam-14214	145	5	o	o	PROPN
bam-14214	145	6	m.	m.	NOUN
bam-14214	145	7	the	the	DET
bam-14214	145	8	klotho	klotho	VERB
bam-14214	145	9	proteins	protein	NOUN
bam-14214	145	10	in	in	ADP
bam-14214	145	11	health	health	NOUN
bam-14214	145	12	and	and	CCONJ
bam-14214	145	13	disease	disease	NOUN
bam-14214	145	14	.	.	PUNCT
bam-14214	146	1	nat	nat	PROPN
bam-14214	146	2	rev	rev	VERB
bam-14214	146	3	nephrol	nephrol	PROPN
bam-14214	146	4	2019;15:27	2019;15:27	NUM
bam-14214	146	5	-	-	SYM
bam-14214	146	6	44	44	NUM
bam-14214	146	7	.	.	PUNCT
bam-14214	147	1	6	6	NUM
bam-14214	147	2	.	.	PUNCT
bam-14214	147	3	prud’homme	prud’homme	PROPN
bam-14214	147	4	gj	gj	PROPN
bam-14214	147	5	,	,	PUNCT
bam-14214	147	6	kurt	kurt	PROPN
bam-14214	147	7	m	m	PROPN
bam-14214	147	8	,	,	PUNCT
bam-14214	147	9	wang	wang	PROPN
bam-14214	147	10	q.	q.	PROPN
bam-14214	147	11	pathobiology	pathobiology	NOUN
bam-14214	147	12	of	of	ADP
bam-14214	147	13	the	the	DET
bam-14214	147	14	klotho	klotho	PROPN
bam-14214	147	15	antiaging	antiage	VERB
bam-14214	147	16	protein	protein	NOUN
bam-14214	147	17	and	and	CCONJ
bam-14214	147	18	therapeutic	therapeutic	ADJ
bam-14214	147	19	considerations	consideration	NOUN
bam-14214	147	20	.	.	PUNCT
bam-14214	148	1	front	front	ADJ
bam-14214	148	2	aging	age	VERB
bam-14214	148	3	2022;3:931331	2022;3:931331	NOUN
bam-14214	148	4	.	.	PUNCT
bam-14214	149	1	7	7	X
bam-14214	149	2	.	.	X
bam-14214	149	3	avin	avin	PROPN
bam-14214	149	4	kg	kg	PROPN
bam-14214	149	5	,	,	PUNCT
bam-14214	149	6	coen	coen	PROPN
bam-14214	149	7	pm	pm	PROPN
bam-14214	149	8	,	,	PUNCT
bam-14214	149	9	huang	huang	PROPN
bam-14214	149	10	w	w	PROPN
bam-14214	149	11	,	,	PUNCT
bam-14214	149	12	et	et	PROPN
bam-14214	149	13	al	al	PROPN
bam-14214	149	14	.	.	PROPN
bam-14214	149	15	skeletal	skeletal	ADJ
bam-14214	149	16	muscle	muscle	NOUN
bam-14214	149	17	as	as	ADP
bam-14214	149	18	a	a	DET
bam-14214	149	19	regulator	regulator	NOUN
bam-14214	149	20	of	of	ADP
bam-14214	149	21	the	the	DET
bam-14214	149	22	longevity	longevity	NOUN
bam-14214	149	23	protein	protein	NOUN
bam-14214	149	24	,	,	PUNCT
bam-14214	149	25	klotho	klotho	PROPN
bam-14214	149	26	.	.	PROPN
bam-14214	150	1	front	front	ADJ
bam-14214	150	2	physiol	physiol	PROPN
bam-14214	150	3	2014;5:189	2014;5:189	NOUN
bam-14214	150	4	.	.	PROPN
bam-14214	150	5	8	8	NUM
bam-14214	150	6	.	.	X
bam-14214	151	1	iturriaga	iturriaga	PROPN
bam-14214	151	2	ramírez	ramírez	PROPN
bam-14214	151	3	t	t	PROPN
bam-14214	151	4	,	,	PUNCT
bam-14214	151	5	yvert	yvert	NOUN
bam-14214	151	6	tp	tp	NOUN
bam-14214	151	7	,	,	PUNCT
bam-14214	151	8	sánchez	sánchez	PROPN
bam-14214	151	9	lorente	lorente	PROPN
bam-14214	151	10	i	i	PRON
bam-14214	151	11	m	m	PROPN
bam-14214	151	12	,	,	PUNCT
bam-14214	151	13	et	et	PROPN
bam-14214	151	14	al	al	PROPN
bam-14214	151	15	.	.	PROPN
bam-14214	151	16	acute	acute	PROPN
bam-14214	151	17	impacts	impact	NOUN
bam-14214	151	18	of	of	ADP
bam-14214	151	19	different	different	ADJ
bam-14214	151	20	types	type	NOUN
bam-14214	151	21	of	of	ADP
bam-14214	151	22	exercise	exercise	NOUN
bam-14214	151	23	on	on	ADP
bam-14214	151	24	circulating	circulate	VERB
bam-14214	151	25	α	α	NUM
bam-14214	151	26	-	-	PUNCT
bam-14214	151	27	klotho	klotho	VERB
bam-14214	151	28	protein	protein	NOUN
bam-14214	151	29	levels	level	NOUN
bam-14214	151	30	.	.	PUNCT
bam-14214	152	1	front	front	ADJ
bam-14214	152	2	physiol	physiol	PROPN
bam-14214	152	3	2021;12:716473	2021;12:716473	NUM
bam-14214	152	4	.	.	PROPN
bam-14214	152	5	9	9	NUM
bam-14214	152	6	.	.	X
bam-14214	153	1	jiang	jiang	PROPN
bam-14214	153	2	s	s	PROPN
bam-14214	153	3	,	,	PUNCT
bam-14214	153	4	bae	bae	PROPN
bam-14214	153	5	j	j	PROPN
bam-14214	153	6	-	-	PROPN
bam-14214	153	7	h	h	PROPN
bam-14214	153	8	,	,	PUNCT
bam-14214	153	9	wang	wang	PROPN
bam-14214	153	10	y	y	PROPN
bam-14214	153	11	,	,	PUNCT
bam-14214	153	12	song	song	NOUN
bam-14214	153	13	w.	w.	PROPN
bam-14214	153	14	the	the	DET
bam-14214	153	15	potential	potential	ADJ
bam-14214	153	16	roles	role	NOUN
bam-14214	153	17	of	of	ADP
bam-14214	153	18	myokines	myokine	NOUN
bam-14214	153	19	in	in	ADP
bam-14214	153	20	adipose	adipose	PRON
bam-14214	153	21	tissue	tissue	NOUN
bam-14214	153	22	metabolism	metabolism	NOUN
bam-14214	153	23	with	with	ADP
bam-14214	153	24	exercise	exercise	NOUN
bam-14214	153	25	and	and	CCONJ
bam-14214	153	26	cold	cold	ADJ
bam-14214	153	27	exposure	exposure	NOUN
bam-14214	153	28	.	.	PUNCT
bam-14214	154	1	int	int	NOUN
bam-14214	154	2	j	j	PROPN
bam-14214	154	3	molecular	molecular	ADJ
bam-14214	154	4	sci	sci	PROPN
bam-14214	154	5	2022;23:11523	2022;23:11523	NUM
bam-14214	154	6	.	.	PUNCT
bam-14214	155	1	10	10	NUM
bam-14214	155	2	.	.	PUNCT
bam-14214	156	1	momenzadeh	momenzadeh	PROPN
bam-14214	156	2	s	s	PROPN
bam-14214	156	3	,	,	PUNCT
bam-14214	156	4	zamani	zamani	PROPN
bam-14214	156	5	s	s	PROPN
bam-14214	156	6	,	,	PUNCT
bam-14214	156	7	dehghan	dehghan	PROPN
bam-14214	156	8	f	f	PROPN
bam-14214	156	9	,	,	PUNCT
bam-14214	156	10	et	et	PROPN
bam-14214	156	11	al	al	PROPN
bam-14214	156	12	.	.	PROPN
bam-14214	156	13	comparative	comparative	ADJ
bam-14214	156	14	proteome	proteome	PROPN
bam-14214	156	15	analyses	analysis	NOUN
bam-14214	156	16	highlight	highlight	VERB
bam-14214	156	17	several	several	ADJ
bam-14214	156	18	exercise‐like	exercise‐like	NOUN
bam-14214	156	19	responses	response	NOUN
bam-14214	156	20	of	of	ADP
bam-14214	156	21	mouse	mouse	NOUN
bam-14214	156	22	sciatic	sciatic	ADJ
bam-14214	156	23	nerve	nerve	NOUN
bam-14214	156	24	after	after	ADP
bam-14214	156	25	ip	ip	DET
bam-14214	156	26	injection	injection	NOUN
bam-14214	156	27	of	of	ADP
bam-14214	156	28	irisin	irisin	NOUN
bam-14214	156	29	.	.	PUNCT
bam-14214	157	1	eur	eur	PROPN
bam-14214	157	2	j	j	PROPN
bam-14214	157	3	neurosci	neurosci	PROPN
bam-14214	157	4	2021;53:3262	2021;53:3262	PROPN
bam-14214	157	5	-	-	SYM
bam-14214	157	6	77	77	NUM
bam-14214	157	7	.	.	PUNCT
bam-14214	157	8	11	11	NUM
bam-14214	157	9	.	.	PUNCT
bam-14214	158	1	gouda	gouda	NOUN
bam-14214	158	2	a	a	PROPN
bam-14214	158	3	,	,	PUNCT
bam-14214	158	4	tolba	tolba	PROPN
bam-14214	158	5	s	s	PART
bam-14214	158	6	,	,	PUNCT
bam-14214	158	7	mahrose	mahrose	ADJ
bam-14214	158	8	k	k	PROPN
bam-14214	158	9	,	,	PUNCT
bam-14214	158	10	et	et	PROPN
bam-14214	158	11	al	al	PROPN
bam-14214	158	12	.	.	PROPN
bam-14214	158	13	heat	heat	NOUN
bam-14214	158	14	shock	shock	NOUN
bam-14214	158	15	proteins	protein	NOUN
bam-14214	158	16	as	as	ADP
bam-14214	158	17	a	a	DET
bam-14214	158	18	key	key	ADJ
bam-14214	158	19	defense	defense	NOUN
bam-14214	158	20	mechanism	mechanism	NOUN
bam-14214	158	21	in	in	ADP
bam-14214	158	22	poultry	poultry	NOUN
bam-14214	158	23	production	production	NOUN
bam-14214	158	24	under	under	ADP
bam-14214	158	25	heat	heat	NOUN
bam-14214	158	26	stress	stress	NOUN
bam-14214	158	27	conditions	condition	NOUN
bam-14214	158	28	.	.	PUNCT
bam-14214	159	1	poultry	poultry	NOUN
bam-14214	159	2	sci	sci	PROPN
bam-14214	159	3	2024:103537	2024:103537	PROPN
bam-14214	159	4	.	.	PROPN
bam-14214	159	5	12	12	NUM
bam-14214	159	6	.	.	PUNCT
bam-14214	160	1	dehghan	dehghan	PROPN
bam-14214	160	2	f	f	PROPN
bam-14214	160	3	,	,	PUNCT
bam-14214	160	4	zamani	zamani	PROPN
bam-14214	160	5	s	s	PROPN
bam-14214	160	6	,	,	PUNCT
bam-14214	160	7	barreiro	barreiro	NOUN
bam-14214	160	8	c	c	NOUN
bam-14214	160	9	,	,	PUNCT
bam-14214	160	10	jami	jami	PROPN
bam-14214	160	11	ms	ms	PROPN
bam-14214	160	12	.	.	PROPN
bam-14214	160	13	irisin	irisin	PROPN
bam-14214	160	14	injection	injection	NOUN
bam-14214	160	15	mimics	mimic	VERB
bam-14214	160	16	exercise	exercise	NOUN
bam-14214	160	17	effects	effect	NOUN
bam-14214	160	18	on	on	ADP
bam-14214	160	19	the	the	DET
bam-14214	160	20	brain	brain	NOUN
bam-14214	160	21	proteome	proteome	NOUN
bam-14214	160	22	.	.	PUNCT
bam-14214	161	1	eur	eur	PROPN
bam-14214	161	2	j	j	PROPN
bam-14214	161	3	neurosci	neurosci	PROPN
bam-14214	161	4	2021;54:7422	2021;54:7422	NUM
bam-14214	161	5	-	-	SYM
bam-14214	161	6	41	41	NUM
bam-14214	161	7	.	.	NOUN
bam-14214	161	8	13	13	NUM
bam-14214	161	9	.	.	PUNCT
bam-14214	162	1	shahabi	shahabi	NOUN
bam-14214	162	2	s	s	PART
bam-14214	162	3	,	,	PUNCT
bam-14214	162	4	esfarjani	esfarjani	X
bam-14214	162	5	f	f	NOUN
bam-14214	162	6	,	,	PUNCT
bam-14214	162	7	reisi	reisi	ADJ
bam-14214	162	8	j	j	PROPN
bam-14214	162	9	,	,	PUNCT
bam-14214	162	10	et	et	NOUN
bam-14214	162	11	als	als	NOUN
bam-14214	162	12	.	.	PUNCT
bam-14214	163	1	the	the	DET
bam-14214	163	2	effects	effect	NOUN
bam-14214	163	3	of	of	ADP
bam-14214	163	4	8	8	NUM
bam-14214	163	5	-	-	PUNCT
bam-14214	163	6	week	week	NOUN
bam-14214	163	7	resistance	resistance	NOUN
bam-14214	163	8	and	and	CCONJ
bam-14214	163	9	endurance	endurance	NOUN
bam-14214	163	10	trainings	training	NOUN
bam-14214	163	11	on	on	ADP
bam-14214	163	12	bone	bone	NOUN
bam-14214	163	13	strength	strength	NOUN
bam-14214	163	14	compared	compare	VERB
bam-14214	163	15	to	to	PART
bam-14214	163	16	irisin	irisin	VERB
bam-14214	163	17	injection	injection	NOUN
bam-14214	163	18	protocol	protocol	NOUN
bam-14214	163	19	in	in	ADP
bam-14214	163	20	mice	mouse	NOUN
bam-14214	163	21	.	.	PUNCT
bam-14214	164	1	adv	adv	PROPN
bam-14214	164	2	biomed	biome	VERB
bam-14214	164	3	res	re	NOUN
bam-14214	164	4	2021;10:40	2021;10:40	NUM
bam-14214	164	5	.	.	PUNCT
bam-14214	165	1	14	14	NUM
bam-14214	165	2	.	.	X
bam-14214	165	3	de	de	PROPN
bam-14214	165	4	sousa	sousa	PROPN
bam-14214	165	5	lages	lag	VERB
bam-14214	165	6	a	a	PRON
bam-14214	165	7	,	,	PUNCT
bam-14214	165	8	lopes	lopes	PROPN
bam-14214	165	9	v	v	PROPN
bam-14214	165	10	,	,	PUNCT
bam-14214	165	11	horta	horta	PROPN
bam-14214	165	12	j	j	PROPN
bam-14214	165	13	,	,	PUNCT
bam-14214	165	14	et	et	PROPN
bam-14214	165	15	al	al	PROPN
bam-14214	165	16	.	.	PUNCT
bam-14214	166	1	therapeutics	therapeutic	NOUN
bam-14214	166	2	that	that	PRON
bam-14214	166	3	can	can	AUX
bam-14214	166	4	potentially	potentially	ADV
bam-14214	166	5	replicate	replicate	VERB
bam-14214	166	6	or	or	CCONJ
bam-14214	166	7	augment	augment	VERB
bam-14214	166	8	the	the	DET
bam-14214	166	9	anti	anti	ADJ
bam-14214	166	10	-	-	ADJ
bam-14214	166	11	aging	aging	ADJ
bam-14214	166	12	effects	effect	NOUN
bam-14214	166	13	of	of	ADP
bam-14214	166	14	physical	physical	ADJ
bam-14214	166	15	exercise	exercise	NOUN
bam-14214	166	16	.	.	PUNCT
bam-14214	167	1	int	int	NOUN
bam-14214	167	2	j	j	PROPN
bam-14214	167	3	molecular	molecular	ADJ
bam-14214	167	4	sc	sc	PROPN
bam-14214	167	5	2022;23:9957	2022;23:9957	NUM
bam-14214	167	6	.	.	PUNCT
bam-14214	167	7	15	15	NUM
bam-14214	167	8	.	.	PUNCT
bam-14214	168	1	zhou	zhou	PROPN
bam-14214	168	2	s	s	PROPN
bam-14214	168	3	,	,	PUNCT
bam-14214	168	4	hum	hum	ADJ
bam-14214	168	5	j	j	PROPN
bam-14214	168	6	,	,	PUNCT
bam-14214	168	7	taskintuna	taskintuna	PROPN
bam-14214	168	8	k	k	PROPN
bam-14214	168	9	,	,	PUNCT
bam-14214	168	10	et	et	PROPN
bam-14214	168	11	al	al	PROPN
bam-14214	168	12	.	.	PUNCT
bam-14214	169	1	the	the	DET
bam-14214	169	2	anti	anti	ADJ
bam-14214	169	3	-	-	ADJ
bam-14214	169	4	aging	aging	ADJ
bam-14214	169	5	hormone	hormone	NOUN
bam-14214	169	6	klotho	klotho	NOUN
bam-14214	169	7	promotes	promote	VERB
bam-14214	169	8	retinal	retinal	ADJ
bam-14214	169	9	pigment	pigment	NOUN
bam-14214	169	10	epithelium	epithelium	NOUN
bam-14214	169	11	cell	cell	NOUN
bam-14214	169	12	viability	viability	NOUN
bam-14214	169	13	and	and	CCONJ
bam-14214	169	14	metabolism	metabolism	NOUN
bam-14214	169	15	by	by	ADP
bam-14214	169	16	activating	activate	VERB
bam-14214	169	17	the	the	DET
bam-14214	169	18	ampk	ampk	NOUN
bam-14214	169	19	/	/	SYM
bam-14214	169	20	pgc-1α	pgc-1α	NOUN
bam-14214	169	21	pathway	pathway	NOUN
bam-14214	169	22	.	.	PUNCT
bam-14214	170	1	antioxidants	antioxidant	NOUN
bam-14214	170	2	2023;12:385	2023;12:385	PROPN
bam-14214	170	3	.	.	PROPN
bam-14214	170	4	15	15	NUM
bam-14214	170	5	16	16	NUM
bam-14214	170	6	.	.	PUNCT
bam-14214	171	1	ji	ji	PROPN
bam-14214	171	2	n	n	PROPN
bam-14214	171	3	,	,	PUNCT
bam-14214	171	4	luan	luan	PROPN
bam-14214	171	5	j	j	PROPN
bam-14214	171	6	,	,	PUNCT
bam-14214	171	7	hu	hu	PROPN
bam-14214	172	1	f	f	PROPN
bam-14214	172	2	,	,	PUNCT
bam-14214	172	3	et	et	PROPN
bam-14214	172	4	al	al	PROPN
bam-14214	172	5	.	.	PROPN
bam-14214	172	6	aerobic	aerobic	ADJ
bam-14214	172	7	exercise‑stimulated	exercise‑stimulate	VERB
bam-14214	172	8	klotho	klotho	VERB
bam-14214	172	9	upregulation	upregulation	NOUN
bam-14214	172	10	extends	extend	VERB
bam-14214	172	11	life	life	NOUN
bam-14214	172	12	span	span	NOUN
bam-14214	172	13	by	by	ADP
bam-14214	172	14	attenuating	attenuate	VERB
bam-14214	172	15	the	the	DET
bam-14214	172	16	excess	excess	ADJ
bam-14214	172	17	production	production	NOUN
bam-14214	172	18	of	of	ADP
bam-14214	172	19	reactive	reactive	ADJ
bam-14214	172	20	oxygen	oxygen	NOUN
bam-14214	172	21	species	specie	NOUN
bam-14214	172	22	in	in	ADP
bam-14214	172	23	the	the	DET
bam-14214	172	24	brain	brain	NOUN
bam-14214	172	25	and	and	CCONJ
bam-14214	172	26	kidney	kidney	NOUN
bam-14214	172	27	.	.	PUNCT
bam-14214	173	1	exper	exper	PROPN
bam-14214	173	2	ther	ther	PROPN
bam-14214	173	3	med	me	VERB
bam-14214	173	4	2018;16:3511	2018;16:3511	NUM
bam-14214	173	5	-	-	SYM
bam-14214	173	6	7	7	NUM
bam-14214	173	7	.	.	NUM
bam-14214	173	8	17	17	NUM
bam-14214	173	9	.	.	X
bam-14214	174	1	ghadamyari	ghadamyari	PROPN
bam-14214	174	2	n	n	CCONJ
bam-14214	174	3	,	,	PUNCT
bam-14214	174	4	zolfaghari	zolfaghari	PROPN
bam-14214	174	5	mr	mr	PROPN
bam-14214	174	6	,	,	PUNCT
bam-14214	174	7	tolouei	tolouei	PROPN
bam-14214	174	8	azar	azar	PROPN
bam-14214	174	9	j	j	PROPN
bam-14214	174	10	,	,	PUNCT
bam-14214	174	11	fattahi	fattahi	PROPN
bam-14214	174	12	a.	a.	NOUN
bam-14214	174	13	the	the	DET
bam-14214	174	14	effect	effect	NOUN
bam-14214	174	15	of	of	ADP
bam-14214	174	16	8	8	NUM
bam-14214	174	17	weeks	week	NOUN
bam-14214	174	18	of	of	ADP
bam-14214	174	19	endurance	endurance	NOUN
bam-14214	174	20	and	and	CCONJ
bam-14214	174	21	resistance	resistance	NOUN
bam-14214	174	22	exercises	exercise	NOUN
bam-14214	174	23	on	on	ADP
bam-14214	174	24	the	the	DET
bam-14214	174	25	serum	serum	NOUN
bam-14214	174	26	levels	level	NOUN
bam-14214	174	27	of	of	ADP
bam-14214	174	28	fgf23	fgf23	PROPN
bam-14214	174	29	and	and	CCONJ
bam-14214	174	30	s	s	NOUN
bam-14214	174	31	-	-	PUNCT
bam-14214	174	32	klotho	klotho	VERB
bam-14214	174	33	in	in	ADP
bam-14214	174	34	type	type	NOUN
bam-14214	174	35	2	2	NUM
bam-14214	174	36	diabetic	diabetic	ADJ
bam-14214	174	37	women	woman	NOUN
bam-14214	174	38	.	.	PUNCT
bam-14214	175	1	int	int	PROPN
bam-14214	175	2	j	j	PROPN
bam-14214	175	3	diabetes	diabetes	PROPN
bam-14214	175	4	dev	dev	PROPN
bam-14214	175	5	ctries	ctrie	VERB
bam-14214	175	6	2025;45:472	2025;45:472	PROPN
bam-14214	175	7	-	-	SYM
bam-14214	175	8	9	9	NUM
bam-14214	175	9	.	.	NOUN
bam-14214	175	10	18	18	NUM
bam-14214	175	11	.	.	PUNCT
bam-14214	176	1	shamsi	shamsi	PROPN
bam-14214	176	2	mm	mm	PROPN
bam-14214	176	3	,	,	PUNCT
bam-14214	176	4	mahdavi	mahdavi	PROPN
bam-14214	176	5	m	m	PROPN
bam-14214	176	6	,	,	PUNCT
bam-14214	176	7	quinn	quinn	PROPN
bam-14214	176	8	l	l	NOUN
bam-14214	176	9	,	,	PUNCT
bam-14214	176	10	et	et	PROPN
bam-14214	176	11	al	al	PROPN
bam-14214	176	12	.	.	PROPN
bam-14214	176	13	effect	effect	NOUN
bam-14214	176	14	of	of	ADP
bam-14214	176	15	resistance	resistance	NOUN
bam-14214	176	16	exercise	exercise	NOUN
bam-14214	176	17	training	training	NOUN
bam-14214	176	18	on	on	ADP
bam-14214	176	19	expression	expression	NOUN
bam-14214	176	20	of	of	ADP
bam-14214	176	21	hsp70	hsp70	NOUN
bam-14214	176	22	and	and	CCONJ
bam-14214	176	23	inflammatory	inflammatory	ADJ
bam-14214	176	24	cytokines	cytokine	NOUN
bam-14214	176	25	in	in	ADP
bam-14214	176	26	skeletal	skeletal	ADJ
bam-14214	176	27	muscle	muscle	NOUN
bam-14214	176	28	and	and	CCONJ
bam-14214	176	29	adipose	adipose	PRON
bam-14214	176	30	tissue	tissue	NOUN
bam-14214	176	31	of	of	ADP
bam-14214	176	32	stz	stz	NOUN
bam-14214	176	33	-	-	PUNCT
bam-14214	176	34	induced	induced	ADJ
bam-14214	176	35	diabetic	diabetic	ADJ
bam-14214	176	36	rats	rat	NOUN
bam-14214	176	37	.	.	PUNCT
bam-14214	177	1	cell	cell	NOUN
bam-14214	177	2	stress	stress	NOUN
bam-14214	177	3	chaperones	chaperone	NOUN
bam-14214	177	4	2016;21:783	2016;21:783	NOUN
bam-14214	177	5	-	-	SYM
bam-14214	177	6	91	91	NUM
bam-14214	177	7	.	.	PUNCT
bam-14214	178	1	19	19	NUM
bam-14214	178	2	.	.	PUNCT
bam-14214	179	1	chen	chen	PROPN
bam-14214	179	2	j	j	PROPN
bam-14214	179	3	,	,	PUNCT
bam-14214	179	4	zhou	zhou	PROPN
bam-14214	179	5	r	r	PROPN
bam-14214	179	6	,	,	PUNCT
bam-14214	179	7	feng	feng	PROPN
bam-14214	179	8	y	y	PROPN
bam-14214	179	9	,	,	PUNCT
bam-14214	179	10	cheng	cheng	PROPN
bam-14214	179	11	l.	l.	PROPN
bam-14214	179	12	molecular	molecular	ADJ
bam-14214	179	13	mechanisms	mechanism	NOUN
bam-14214	179	14	of	of	ADP
bam-14214	179	15	exercise	exercise	NOUN
bam-14214	179	16	contributing	contribute	VERB
bam-14214	179	17	to	to	ADP
bam-14214	179	18	tissue	tissue	NOUN
bam-14214	179	19	regeneration	regeneration	NOUN
bam-14214	179	20	.	.	PUNCT
bam-14214	180	1	signal	signal	PROPN
bam-14214	180	2	transduct	transduct	NOUN
bam-14214	180	3	target	target	NOUN
bam-14214	180	4	ther	ther	PROPN
bam-14214	180	5	2022;7:383	2022;7:383	NOUN
bam-14214	180	6	.	.	PROPN
bam-14214	181	1	20	20	NUM
bam-14214	181	2	.	.	PUNCT
bam-14214	182	1	lin	lin	PROPN
bam-14214	182	2	j	j	PROPN
bam-14214	182	3	,	,	PUNCT
bam-14214	182	4	liu	liu	PROPN
bam-14214	182	5	x	x	PROPN
bam-14214	182	6	,	,	PUNCT
bam-14214	182	7	zhou	zhou	PROPN
bam-14214	182	8	y	y	PROPN
bam-14214	182	9	,	,	PUNCT
bam-14214	182	10	et	et	PROPN
bam-14214	182	11	al	al	PROPN
bam-14214	182	12	.	.	PUNCT
bam-14214	183	1	molecular	molecular	ADJ
bam-14214	183	2	basis	basis	NOUN
bam-14214	183	3	of	of	ADP
bam-14214	183	4	irisin	irisin	NOUN
bam-14214	183	5	regulating	regulate	VERB
bam-14214	183	6	the	the	DET
bam-14214	183	7	effects	effect	NOUN
bam-14214	183	8	of	of	ADP
bam-14214	183	9	exercise	exercise	NOUN
bam-14214	183	10	on	on	ADP
bam-14214	183	11	insulin	insulin	NOUN
bam-14214	183	12	resistance	resistance	NOUN
bam-14214	183	13	.	.	PUNCT
bam-14214	184	1	applied	apply	VERB
bam-14214	184	2	sci	sci	PROPN
bam-14214	184	3	2022;12:5837	2022;12:5837	PROPN
bam-14214	184	4	.	.	PUNCT
bam-14214	185	1	21	21	NUM
bam-14214	185	2	.	.	PUNCT
bam-14214	186	1	laurens	laurens	PROPN
bam-14214	186	2	c	c	PROPN
bam-14214	186	3	,	,	PUNCT
bam-14214	186	4	bergouignan	bergouignan	VERB
bam-14214	186	5	a	a	PRON
bam-14214	186	6	,	,	PUNCT
bam-14214	186	7	moro	moro	PROPN
bam-14214	186	8	c.	c.	PROPN
bam-14214	186	9	exercise	exercise	NOUN
bam-14214	186	10	-	-	PUNCT
bam-14214	186	11	released	release	VERB
bam-14214	186	12	myokines	myokine	NOUN
bam-14214	186	13	in	in	ADP
bam-14214	186	14	the	the	DET
bam-14214	186	15	control	control	NOUN
bam-14214	186	16	of	of	ADP
bam-14214	186	17	energy	energy	NOUN
bam-14214	186	18	metabolism	metabolism	NOUN
bam-14214	186	19	.	.	PUNCT
bam-14214	187	1	front	front	ADJ
bam-14214	187	2	physiol	physiol	PROPN
bam-14214	187	3	2020;11:91	2020;11:91	NUM
bam-14214	187	4	.	.	PUNCT
bam-14214	188	1	22	22	NUM
bam-14214	188	2	.	.	PUNCT
bam-14214	189	1	zhang	zhang	PROPN
bam-14214	189	2	h	h	PROPN
bam-14214	189	3	,	,	PUNCT
bam-14214	189	4	wu	wu	PROPN
bam-14214	189	5	x	x	PROPN
bam-14214	189	6	,	,	PUNCT
bam-14214	189	7	liang	liang	PROPN
bam-14214	189	8	j	j	PROPN
bam-14214	189	9	,	,	PUNCT
bam-14214	189	10	et	et	PROPN
bam-14214	189	11	al	al	PROPN
bam-14214	189	12	.	.	PROPN
bam-14214	189	13	irisin	irisin	PROPN
bam-14214	189	14	,	,	PUNCT
bam-14214	189	15	an	an	DET
bam-14214	189	16	exercise	exercise	NOUN
bam-14214	189	17	-	-	PUNCT
bam-14214	189	18	induced	induce	VERB
bam-14214	189	19	bioactive	bioactive	NOUN
bam-14214	189	20	peptide	peptide	NOUN
bam-14214	189	21	beneficial	beneficial	ADJ
bam-14214	189	22	for	for	ADP
bam-14214	189	23	health	health	NOUN
bam-14214	189	24	promotion	promotion	NOUN
bam-14214	189	25	during	during	ADP
bam-14214	189	26	aging	age	VERB
bam-14214	189	27	process	process	NOUN
bam-14214	189	28	.	.	PUNCT
bam-14214	190	1	ageing	age	VERB
bam-14214	190	2	res	re	NOUN
bam-14214	190	3	rev	rev	VERB
bam-14214	190	4	2022;80:101680	2022;80:101680	NUM
bam-14214	190	5	.	.	PROPN
bam-14214	190	6	23	23	NUM
bam-14214	190	7	.	.	PUNCT
bam-14214	191	1	zhang	zhang	PROPN
bam-14214	191	2	y	y	PROPN
bam-14214	191	3	,	,	PUNCT
bam-14214	191	4	wang	wang	PROPN
bam-14214	191	5	l	l	PROPN
bam-14214	191	6	,	,	PUNCT
bam-14214	191	7	kang	kang	PROPN
bam-14214	191	8	h	h	PROPN
bam-14214	191	9	,	,	PUNCT
bam-14214	191	10	et	et	PROPN
bam-14214	191	11	al	al	PROPN
bam-14214	191	12	.	.	PROPN
bam-14214	191	13	unlocking	unlock	VERB
bam-14214	191	14	the	the	DET
bam-14214	191	15	therapeutic	therapeutic	ADJ
bam-14214	191	16	potential	potential	NOUN
bam-14214	191	17	of	of	ADP
bam-14214	191	18	irisin	irisin	NOUN
bam-14214	191	19	:	:	PUNCT
bam-14214	191	20	harnessing	harness	VERB
bam-14214	191	21	its	its	PRON
bam-14214	191	22	function	function	NOUN
bam-14214	191	23	in	in	ADP
bam-14214	191	24	degenerative	degenerative	ADJ
bam-14214	191	25	disorders	disorder	NOUN
bam-14214	191	26	and	and	CCONJ
bam-14214	191	27	tissue	tissue	NOUN
bam-14214	191	28	regeneration	regeneration	NOUN
bam-14214	191	29	.	.	PUNCT
bam-14214	192	1	int	int	NOUN
bam-14214	192	2	j	j	PROPN
bam-14214	192	3	molecular	molecular	ADJ
bam-14214	192	4	sci	sci	PROPN
bam-14214	192	5	2023;24:6551	2023;24:6551	NUM
bam-14214	192	6	.	.	PROPN
bam-14214	192	7	24	24	NUM
bam-14214	192	8	.	.	NOUN
bam-14214	192	9	rabiee	rabiee	PROPN
bam-14214	192	10	f	f	PROPN
bam-14214	192	11	,	,	PUNCT
bam-14214	192	12	lachinani	lachinani	PROPN
bam-14214	192	13	l	l	PROPN
bam-14214	192	14	,	,	PUNCT
bam-14214	192	15	ghaedi	ghaedi	VERB
bam-14214	192	16	s	s	PROPN
bam-14214	192	17	,	,	PUNCT
bam-14214	192	18	et	et	PROPN
bam-14214	192	19	al	al	PROPN
bam-14214	192	20	.	.	PUNCT
bam-14214	193	1	new	new	ADJ
bam-14214	193	2	insights	insight	NOUN
bam-14214	193	3	into	into	ADP
bam-14214	193	4	the	the	DET
bam-14214	193	5	cellular	cellular	ADJ
bam-14214	193	6	activities	activity	NOUN
bam-14214	193	7	of	of	ADP
bam-14214	193	8	fndc5	fndc5	PROPN
bam-14214	193	9	/	/	SYM
bam-14214	193	10	irisin	irisin	NOUN
bam-14214	193	11	and	and	CCONJ
bam-14214	193	12	its	its	PRON
bam-14214	193	13	signaling	signal	VERB
bam-14214	193	14	pathways	pathway	NOUN
bam-14214	193	15	.	.	PUNCT
bam-14214	194	1	cell	cell	NOUN
bam-14214	194	2	biosci	biosci	PROPN
bam-14214	194	3	2020;10:1	2020;10:1	PROPN
bam-14214	194	4	-	-	SYM
bam-14214	194	5	10	10	NUM
bam-14214	194	6	.	.	PUNCT
bam-14214	194	7	25	25	NUM
bam-14214	194	8	.	.	PUNCT
bam-14214	195	1	waseem	waseem	PROPN
bam-14214	195	2	r	r	PROPN
bam-14214	195	3	,	,	PUNCT
bam-14214	195	4	shamsi	shamsi	PROPN
bam-14214	195	5	a	a	PROPN
bam-14214	195	6	,	,	PUNCT
bam-14214	195	7	mohammad	mohammad	PROPN
bam-14214	195	8	t	t	PROPN
bam-14214	195	9	,	,	PUNCT
bam-14214	195	10	et	et	PROPN
bam-14214	195	11	al	al	PROPN
bam-14214	195	12	.	.	PUNCT
bam-14214	196	1	fndc5	fndc5	PROPN
bam-14214	196	2	/	/	SYM
bam-14214	196	3	irisin	irisin	PROPN
bam-14214	196	4	:	:	PUNCT
bam-14214	196	5	physiology	physiology	NOUN
bam-14214	196	6	and	and	CCONJ
bam-14214	196	7	pathophysiology	pathophysiology	NOUN
bam-14214	196	8	.	.	PUNCT
bam-14214	197	1	molecules	molecule	NOUN
bam-14214	197	2	2022;27:1118	2022;27:1118	NUM
bam-14214	197	3	.	.	NOUN
bam-14214	197	4	26	26	NUM
bam-14214	197	5	.	.	PUNCT
bam-14214	198	1	cui	cui	PROPN
bam-14214	198	2	y	y	PROPN
bam-14214	198	3	,	,	PUNCT
bam-14214	198	4	yu	yu	PROPN
bam-14214	198	5	l	l	PROPN
bam-14214	198	6	,	,	PUNCT
bam-14214	198	7	cong	cong	NOUN
bam-14214	198	8	w	w	PROPN
bam-14214	198	9	,	,	PUNCT
bam-14214	198	10	et	et	PROPN
bam-14214	198	11	al	al	PROPN
bam-14214	198	12	.	.	PROPN
bam-14214	198	13	irisin	irisin	PROPN
bam-14214	198	14	preserves	preserve	VERB
bam-14214	198	15	mitochondrial	mitochondrial	ADJ
bam-14214	198	16	integrity	integrity	NOUN
bam-14214	198	17	and	and	CCONJ
bam-14214	198	18	function	function	NOUN
bam-14214	198	19	in	in	ADP
bam-14214	198	20	tubular	tubular	ADJ
bam-14214	198	21	epithelial	epithelial	ADJ
bam-14214	198	22	cells	cell	NOUN
bam-14214	198	23	after	after	ADP
bam-14214	198	24	ischemia	ischemia	NOUN
bam-14214	198	25	–	–	PUNCT
bam-14214	198	26	reperfusion‐induced	reperfusion‐induce	VERB
bam-14214	198	27	acute	acute	NOUN
bam-14214	198	28	kidney	kidney	NOUN
bam-14214	198	29	injury	injury	NOUN
bam-14214	198	30	.	.	PUNCT
bam-14214	199	1	acta	acta	PROPN
bam-14214	199	2	physiol	physiol	PROPN
bam-14214	199	3	2024;240	2024;240	NUM
bam-14214	199	4	:	:	PUNCT
bam-14214	199	5	e14211	e14211	PROPN
bam-14214	199	6	.	.	PUNCT
bam-14214	200	1	27	27	NUM
bam-14214	200	2	.	.	PUNCT
bam-14214	201	1	sugiura	sugiura	PROPN
bam-14214	201	2	h	h	PROPN
bam-14214	201	3	,	,	PUNCT
bam-14214	201	4	yoshida	yoshida	PROPN
bam-14214	201	5	t	t	PROPN
bam-14214	201	6	,	,	PUNCT
bam-14214	201	7	mitobe	mitobe	NOUN
bam-14214	201	8	m	m	PROPN
bam-14214	201	9	,	,	PUNCT
bam-14214	201	10	et	et	PROPN
bam-14214	201	11	al	al	PROPN
bam-14214	201	12	.	.	PROPN
bam-14214	201	13	klotho	klotho	PROPN
bam-14214	201	14	reduces	reduce	VERB
bam-14214	201	15	apoptosis	apoptosis	NOUN
bam-14214	201	16	in	in	ADP
bam-14214	201	17	experimental	experimental	ADJ
bam-14214	201	18	ischaemic	ischaemic	ADJ
bam-14214	201	19	acute	acute	PROPN
bam-14214	201	20	kidney	kidney	NOUN
bam-14214	201	21	injury	injury	NOUN
bam-14214	201	22	via	via	ADP
bam-14214	201	23	hsp-70	hsp-70	PROPN
bam-14214	201	24	.	.	PUNCT
bam-14214	201	25	nephrol	nephrol	PROPN
bam-14214	201	26	dial	dial	NOUN
bam-14214	201	27	transplant	transplant	NOUN
bam-14214	201	28	2010;25:60	2010;25:60	NUM
bam-14214	201	29	-	-	SYM
bam-14214	201	30	8	8	NUM
bam-14214	201	31	.	.	PUNCT
bam-14214	201	32	28	28	NUM
bam-14214	201	33	.	.	PUNCT
bam-14214	202	1	rizk	rizk	PROPN
bam-14214	202	2	fh	fh	PROPN
bam-14214	202	3	,	,	PUNCT
bam-14214	202	4	soliman	soliman	NOUN
bam-14214	202	5	na	na	PROPN
bam-14214	202	6	,	,	PUNCT
bam-14214	202	7	heabah	heabah	X
bam-14214	202	8	na	na	PROPN
bam-14214	202	9	,	,	PUNCT
bam-14214	202	10	et	et	PROPN
bam-14214	202	11	al	al	PROPN
bam-14214	202	12	.	.	PROPN
bam-14214	202	13	fenofibrate	fenofibrate	PROPN
bam-14214	202	14	improves	improve	VERB
bam-14214	202	15	cognitive	cognitive	ADJ
bam-14214	202	16	impairment	impairment	NOUN
bam-14214	202	17	induced	induce	VERB
bam-14214	202	18	by	by	ADP
bam-14214	202	19	high	high	ADJ
bam-14214	202	20	-	-	PUNCT
bam-14214	202	21	fat	fat	NOUN
bam-14214	202	22	high	high	ADJ
bam-14214	202	23	-	-	PUNCT
bam-14214	202	24	fructose	fructose	NOUN
bam-14214	202	25	diet	diet	NOUN
bam-14214	202	26	:	:	PUNCT
bam-14214	202	27	a	a	DET
bam-14214	202	28	possible	possible	ADJ
bam-14214	202	29	role	role	NOUN
bam-14214	202	30	of	of	ADP
bam-14214	202	31	irisin	irisin	NOUN
bam-14214	202	32	and	and	CCONJ
bam-14214	202	33	heat	heat	NOUN
bam-14214	202	34	shock	shock	NOUN
bam-14214	202	35	proteins	protein	NOUN
bam-14214	202	36	.	.	PUNCT
bam-14214	203	1	acs	acs	PROPN
bam-14214	203	2	chem	chem	NOUN
bam-14214	203	3	neurosci	neurosci	NOUN
bam-14214	203	4	2022;13:1782	2022;13:1782	NUM
bam-14214	203	5	-	-	SYM
bam-14214	203	6	9	9	NUM
bam-14214	203	7	.	.	NOUN
bam-14214	203	8	29	29	NUM
bam-14214	203	9	.	.	PUNCT
bam-14214	204	1	feng	feng	PROPN
bam-14214	204	2	m	m	PROPN
bam-14214	204	3	,	,	PUNCT
bam-14214	204	4	li	li	PROPN
bam-14214	204	5	m	m	PROPN
bam-14214	204	6	,	,	PUNCT
bam-14214	204	7	lou	lou	PROPN
bam-14214	204	8	j	j	PROPN
bam-14214	204	9	,	,	PUNCT
bam-14214	204	10	et	et	PROPN
bam-14214	204	11	al	al	PROPN
bam-14214	204	12	.	.	PUNCT
bam-14214	205	1	early	early	ADJ
bam-14214	205	2	-	-	PUNCT
bam-14214	205	3	life	life	NOUN
bam-14214	205	4	exercise	exercise	NOUN
bam-14214	205	5	extends	extend	VERB
bam-14214	205	6	healthspan	healthspan	NOUN
bam-14214	205	7	but	but	CCONJ
bam-14214	205	8	not	not	PART
bam-14214	205	9	lifespan	lifespan	VERB
bam-14214	205	10	in	in	ADP
bam-14214	205	11	mice	mouse	NOUN
bam-14214	205	12	.	.	PUNCT
bam-14214	206	1	nat	nat	PROPN
bam-14214	206	2	commun	commun	PROPN
bam-14214	206	3	2025;16:6328	2025;16:6328	PROPN
bam-14214	206	4	.	.	PROPN
bam-14214	207	1	16	16	NUM
bam-14214	207	2	30	30	NUM
bam-14214	207	3	.	.	PUNCT
bam-14214	208	1	sahu	sahu	PROPN
bam-14214	208	2	a	a	PROPN
bam-14214	208	3	,	,	PUNCT
bam-14214	208	4	mamiya	mamiya	PROPN
bam-14214	208	5	h	h	NOUN
bam-14214	208	6	,	,	PUNCT
bam-14214	208	7	shinde	shinde	PROPN
bam-14214	208	8	s	s	PROPN
bam-14214	208	9	,	,	PUNCT
bam-14214	208	10	et	et	PROPN
bam-14214	208	11	al	al	PROPN
bam-14214	208	12	.	.	PUNCT
bam-14214	208	13	age	age	NOUN
bam-14214	208	14	-	-	PUNCT
bam-14214	208	15	related	relate	VERB
bam-14214	208	16	declines	decline	NOUN
bam-14214	208	17	in	in	ADP
bam-14214	208	18	α	α	NOUN
bam-14214	208	19	-	-	PUNCT
bam-14214	208	20	klotho	klotho	VERB
bam-14214	208	21	drive	drive	NOUN
bam-14214	208	22	progenitor	progenitor	NOUN
bam-14214	208	23	cell	cell	NOUN
bam-14214	208	24	mitochondrial	mitochondrial	ADJ
bam-14214	208	25	dysfunction	dysfunction	NOUN
bam-14214	208	26	and	and	CCONJ
bam-14214	208	27	impaired	impaired	ADJ
bam-14214	208	28	muscle	muscle	NOUN
bam-14214	208	29	regeneration	regeneration	NOUN
bam-14214	208	30	.	.	PUNCT
bam-14214	209	1	nat	nat	PROPN
bam-14214	209	2	commun	commun	PROPN
bam-14214	209	3	2018;9:4859	2018;9:4859	PROPN
bam-14214	209	4	.	.	PROPN
bam-14214	210	1	31	31	NUM
bam-14214	210	2	.	.	PUNCT
bam-14214	211	1	prud’homme	prud’homme	PROPN
bam-14214	211	2	gj	gj	PROPN
bam-14214	211	3	,	,	PUNCT
bam-14214	211	4	wang	wang	PROPN
bam-14214	211	5	q.	q.	PROPN
bam-14214	211	6	anti	anti	ADJ
bam-14214	211	7	-	-	ADJ
bam-14214	211	8	inflammatory	inflammatory	ADJ
bam-14214	211	9	role	role	NOUN
bam-14214	211	10	of	of	ADP
bam-14214	211	11	the	the	DET
bam-14214	211	12	klotho	klotho	ADJ
bam-14214	211	13	protein	protein	NOUN
bam-14214	211	14	and	and	CCONJ
bam-14214	211	15	relevance	relevance	NOUN
bam-14214	211	16	to	to	ADP
bam-14214	211	17	aging	age	VERB
bam-14214	211	18	.	.	PUNCT
bam-14214	212	1	cells	cell	NOUN
bam-14214	212	2	2024;13:1413	2024;13:1413	NUM
bam-14214	212	3	.	.	PUNCT
bam-14214	213	1	32	32	NUM
bam-14214	213	2	.	.	PUNCT
bam-14214	214	1	kurosu	kurosu	PROPN
bam-14214	214	2	h	h	PROPN
bam-14214	214	3	,	,	PUNCT
bam-14214	214	4	yamamoto	yamamoto	PROPN
bam-14214	214	5	m	m	PROPN
bam-14214	214	6	,	,	PUNCT
bam-14214	214	7	clark	clark	PROPN
bam-14214	214	8	jd	jd	PROPN
bam-14214	214	9	,	,	PUNCT
bam-14214	214	10	pastor	pastor	NOUN
bam-14214	214	11	jv	jv	PROPN
bam-14214	214	12	,	,	PUNCT
bam-14214	214	13	nandi	nandi	PROPN
bam-14214	214	14	a	a	PROPN
bam-14214	214	15	,	,	PUNCT
bam-14214	214	16	gurnani	gurnani	PROPN
bam-14214	214	17	p	p	X
bam-14214	214	18	,	,	PUNCT
bam-14214	214	19	et	et	PROPN
bam-14214	214	20	al	al	PROPN
bam-14214	214	21	.	.	PROPN
bam-14214	214	22	suppression	suppression	NOUN
bam-14214	214	23	of	of	ADP
bam-14214	214	24	aging	age	VERB
bam-14214	214	25	in	in	ADP
bam-14214	214	26	mice	mouse	NOUN
bam-14214	214	27	by	by	ADP
bam-14214	214	28	the	the	DET
bam-14214	214	29	hormone	hormone	NOUN
bam-14214	214	30	klotho	klotho	NOUN
bam-14214	214	31	.	.	PUNCT
bam-14214	215	1	science	science	PROPN
bam-14214	215	2	2005;309:1829	2005;309:1829	NUM
bam-14214	215	3	-	-	SYM
bam-14214	215	4	33	33	NUM
bam-14214	215	5	.	.	PUNCT
bam-14214	215	6	33	33	NUM
bam-14214	215	7	.	.	PUNCT
bam-14214	216	1	li	li	PROPN
bam-14214	216	2	-	-	PROPN
bam-14214	216	3	zhen	zhen	PROPN
bam-14214	216	4	l	l	PROPN
bam-14214	216	5	,	,	PUNCT
bam-14214	216	6	chen	chen	PROPN
bam-14214	216	7	z	z	PROPN
bam-14214	216	8	-	-	PUNCT
bam-14214	216	9	c	c	PROPN
bam-14214	216	10	,	,	PUNCT
bam-14214	216	11	wang	wang	PROPN
bam-14214	216	12	s	s	PROPN
bam-14214	216	13	-	-	PUNCT
bam-14214	216	14	s	s	PROPN
bam-14214	216	15	,	,	PUNCT
bam-14214	216	16	et	et	PROPN
bam-14214	216	17	al	al	PROPN
bam-14214	216	18	.	.	PROPN
bam-14214	216	19	klotho	klotho	PROPN
bam-14214	216	20	deficiency	deficiency	NOUN
bam-14214	216	21	causes	cause	VERB
bam-14214	216	22	cardiac	cardiac	ADJ
bam-14214	216	23	ageing	ageing	NOUN
bam-14214	216	24	by	by	ADP
bam-14214	216	25	impairing	impair	VERB
bam-14214	216	26	autophagic	autophagic	NOUN
bam-14214	216	27	and	and	CCONJ
bam-14214	216	28	activating	activate	VERB
bam-14214	216	29	apoptotic	apoptotic	ADJ
bam-14214	216	30	activity	activity	NOUN
bam-14214	216	31	.	.	PUNCT
bam-14214	217	1	eur	eur	PROPN
bam-14214	217	2	j	j	PROPN
bam-14214	217	3	pharmacol	pharmacol	PROPN
bam-14214	217	4	2021;911:174559	2021;911:174559	NUM
bam-14214	217	5	.	.	PUNCT
bam-14214	218	1	figure	figure	NOUN
bam-14214	218	2	1	1	NUM
bam-14214	218	3	.	.	PUNCT
bam-14214	219	1	plasma	plasma	NOUN
bam-14214	219	2	irisin	irisin	PROPN
bam-14214	219	3	levels	level	NOUN
bam-14214	219	4	in	in	ADP
bam-14214	219	5	nmri	nmri	ADJ
bam-14214	219	6	mice	mouse	NOUN
bam-14214	219	7	in	in	ADP
bam-14214	219	8	response	response	NOUN
bam-14214	219	9	to	to	PART
bam-14214	219	10	irisin	irisin	VERB
bam-14214	219	11	injection	injection	NOUN
bam-14214	219	12	and	and	CCONJ
bam-14214	219	13	physical	physical	ADJ
bam-14214	219	14	exercise	exercise	NOUN
bam-14214	219	15	.	.	PUNCT
bam-14214	220	1	the	the	DET
bam-14214	220	2	control	control	NOUN
bam-14214	220	3	,	,	PUNCT
bam-14214	220	4	resistance	resistance	NOUN
bam-14214	220	5	,	,	PUNCT
bam-14214	220	6	endurance	endurance	NOUN
bam-14214	220	7	,	,	PUNCT
bam-14214	220	8	and	and	CCONJ
bam-14214	220	9	irisin	irisin	VERB
bam-14214	220	10	injection	injection	NOUN
bam-14214	220	11	groups	group	NOUN
bam-14214	220	12	'	'	PART
bam-14214	220	13	plasma	plasma	NOUN
bam-14214	220	14	irisin	irisin	NOUN
bam-14214	220	15	concentrations	concentration	NOUN
bam-14214	220	16	were	be	AUX
bam-14214	220	17	measured	measure	VERB
bam-14214	220	18	72	72	NUM
bam-14214	220	19	hours	hour	NOUN
bam-14214	220	20	after	after	ADP
bam-14214	220	21	the	the	DET
bam-14214	220	22	last	last	ADJ
bam-14214	220	23	intervention	intervention	NOUN
bam-14214	220	24	.	.	PUNCT
bam-14214	221	1	when	when	SCONJ
bam-14214	221	2	compared	compare	VERB
bam-14214	221	3	to	to	ADP
bam-14214	221	4	the	the	DET
bam-14214	221	5	control	control	NOUN
bam-14214	221	6	group	group	NOUN
bam-14214	221	7	,	,	PUNCT
bam-14214	221	8	both	both	DET
bam-14214	221	9	types	type	NOUN
bam-14214	221	10	of	of	ADP
bam-14214	221	11	exercise	exercise	NOUN
bam-14214	221	12	and	and	CCONJ
bam-14214	221	13	irisin	irisin	VERB
bam-14214	221	14	injection	injection	NOUN
bam-14214	221	15	significantly	significantly	ADV
bam-14214	221	16	increased	increase	VERB
bam-14214	221	17	plasma	plasma	NOUN
bam-14214	221	18	irisin	irisin	NOUN
bam-14214	221	19	levels	level	NOUN
bam-14214	221	20	,	,	PUNCT
bam-14214	221	21	with	with	ADP
bam-14214	221	22	resistance	resistance	NOUN
bam-14214	221	23	exercise	exercise	NOUN
bam-14214	221	24	exhibiting	exhibit	VERB
bam-14214	221	25	the	the	DET
bam-14214	221	26	highest	high	ADJ
bam-14214	221	27	rise	rise	NOUN
bam-14214	221	28	.	.	PUNCT
bam-14214	222	1	the	the	DET
bam-14214	222	2	data	datum	NOUN
bam-14214	222	3	is	be	AUX
bam-14214	222	4	displayed	display	VERB
bam-14214	222	5	as	as	ADP
bam-14214	222	6	mean±sd	mean±sd	PROPN
bam-14214	222	7	.	.	PUNCT
bam-14214	223	1	significant	significant	ADJ
bam-14214	223	2	values	value	NOUN
bam-14214	223	3	were	be	AUX
bam-14214	223	4	defined	define	VERB
bam-14214	223	5	as	as	ADP
bam-14214	223	6	p≤0.001	p≤0.001	PROPN
bam-14214	223	7	,	,	PUNCT
bam-14214	223	8	(	(	PUNCT
bam-14214	223	9	*	*	PUNCT
bam-14214	223	10	*	*	PUNCT
bam-14214	223	11	*	*	PUNCT
bam-14214	223	12	)	)	PUNCT
bam-14214	223	13	,	,	PUNCT
bam-14214	223	14	p≤0.01	p≤0.01	NOUN
bam-14214	223	15	(	(	PUNCT
bam-14214	223	16	*	*	PUNCT
bam-14214	223	17	*	*	PUNCT
bam-14214	223	18	)	)	PUNCT
bam-14214	223	19	,	,	PUNCT
bam-14214	223	20	and	and	CCONJ
bam-14214	223	21	p≤0.05	p≤0.05	NOUN
bam-14214	223	22	(	(	PUNCT
bam-14214	223	23	*	*	NOUN
bam-14214	223	24	)	)	PUNCT
bam-14214	223	25	.	.	PUNCT
bam-14214	224	1	17	17	NUM
bam-14214	224	2	figure	figure	NOUN
bam-14214	224	3	2	2	NUM
bam-14214	224	4	.	.	PUNCT
bam-14214	224	5	effect	effect	NOUN
bam-14214	224	6	of	of	ADP
bam-14214	224	7	exercise	exercise	NOUN
bam-14214	224	8	and	and	CCONJ
bam-14214	224	9	irisin	irisin	VERB
bam-14214	224	10	injection	injection	NOUN
bam-14214	224	11	on	on	ADP
bam-14214	224	12	klotho	klotho	PROPN
bam-14214	224	13	and	and	CCONJ
bam-14214	224	14	hsp70	hsp70	NOUN
bam-14214	224	15	expression	expression	NOUN
bam-14214	224	16	in	in	ADP
bam-14214	224	17	kidney	kidney	NOUN
bam-14214	224	18	tissue	tissue	NOUN
bam-14214	224	19	of	of	ADP
bam-14214	224	20	nmri	nmri	ADJ
bam-14214	224	21	mice	mouse	NOUN
bam-14214	224	22	.	.	PUNCT
bam-14214	225	1	(	(	PUNCT
bam-14214	225	2	a	a	PRON
bam-14214	225	3	,	,	PUNCT
bam-14214	225	4	b	b	NOUN
bam-14214	225	5	)	)	PUNCT
bam-14214	225	6	western	western	ADJ
bam-14214	225	7	blot	blot	NOUN
bam-14214	225	8	(	(	PUNCT
bam-14214	225	9	a	a	NOUN
bam-14214	225	10	)	)	PUNCT
bam-14214	225	11	and	and	CCONJ
bam-14214	225	12	densitometric	densitometric	ADJ
bam-14214	225	13	quantification	quantification	NOUN
bam-14214	225	14	(	(	PUNCT
bam-14214	225	15	b	b	NOUN
bam-14214	225	16	)	)	PUNCT
bam-14214	225	17	of	of	ADP
bam-14214	225	18	klotho	klotho	VERB
bam-14214	225	19	protein	protein	NOUN
bam-14214	225	20	18	18	NUM
bam-14214	225	21	levels	level	NOUN
bam-14214	225	22	(	(	PUNCT
bam-14214	225	23	~62	~62	NOUN
bam-14214	225	24	kda	kda	NOUN
bam-14214	225	25	)	)	PUNCT
bam-14214	225	26	,	,	PUNCT
bam-14214	225	27	normalized	normalize	VERB
bam-14214	225	28	to	to	ADP
bam-14214	225	29	gapdh	gapdh	NOUN
bam-14214	225	30	(	(	PUNCT
bam-14214	225	31	~37	~37	NOUN
bam-14214	225	32	kda	kda	NOUN
bam-14214	225	33	)	)	PUNCT
bam-14214	225	34	(	(	PUNCT
bam-14214	225	35	shown	show	VERB
bam-14214	225	36	as	as	SCONJ
bam-14214	225	37	normalized	normalize	VERB
bam-14214	225	38	intensity	intensity	NOUN
bam-14214	225	39	values	value	NOUN
bam-14214	225	40	)	)	PUNCT
bam-14214	225	41	.	.	PUNCT
bam-14214	226	1	(	(	PUNCT
bam-14214	226	2	c	c	X
bam-14214	226	3	,	,	PUNCT
bam-14214	226	4	d	d	NOUN
bam-14214	226	5	)	)	PUNCT
bam-14214	226	6	western	western	ADJ
bam-14214	226	7	blot	blot	NOUN
bam-14214	226	8	(	(	PUNCT
bam-14214	226	9	c	c	NOUN
bam-14214	226	10	)	)	PUNCT
bam-14214	226	11	and	and	CCONJ
bam-14214	226	12	densitometric	densitometric	ADJ
bam-14214	226	13	quantification	quantification	NOUN
bam-14214	226	14	(	(	PUNCT
bam-14214	226	15	d	d	NOUN
bam-14214	226	16	)	)	PUNCT
bam-14214	226	17	of	of	ADP
bam-14214	226	18	hsp70	hsp70	NOUN
bam-14214	226	19	protein	protein	NOUN
bam-14214	226	20	levels	level	NOUN
bam-14214	226	21	(	(	PUNCT
bam-14214	226	22	~70	~70	X
bam-14214	226	23	kda	kda	NOUN
bam-14214	226	24	)	)	PUNCT
bam-14214	226	25	,	,	PUNCT
bam-14214	226	26	normalized	normalize	VERB
bam-14214	226	27	to	to	ADP
bam-14214	226	28	gapdh	gapdh	NOUN
bam-14214	226	29	(	(	PUNCT
bam-14214	226	30	~37	~37	NOUN
bam-14214	226	31	kda	kda	NOUN
bam-14214	226	32	)	)	PUNCT
bam-14214	226	33	(	(	PUNCT
bam-14214	226	34	shown	show	VERB
bam-14214	226	35	as	as	SCONJ
bam-14214	226	36	normalized	normalize	VERB
bam-14214	226	37	intensity	intensity	NOUN
bam-14214	226	38	values	value	NOUN
bam-14214	226	39	)	)	PUNCT
bam-14214	226	40	.	.	PUNCT
bam-14214	227	1	all	all	DET
bam-14214	227	2	intervention	intervention	NOUN
bam-14214	227	3	groups	group	NOUN
bam-14214	227	4	showed	show	VERB
bam-14214	227	5	significantly	significantly	ADV
bam-14214	227	6	higher	high	ADJ
bam-14214	227	7	expression	expression	NOUN
bam-14214	227	8	compared	compare	VERB
bam-14214	227	9	to	to	ADP
bam-14214	227	10	control	control	NOUN
bam-14214	227	11	(	(	PUNCT
bam-14214	227	12	,	,	PUNCT
bam-14214	227	13	p<0.001	p<0.001	PROPN
bam-14214	227	14	)	)	PUNCT
bam-14214	227	15	.	.	PUNCT
bam-14214	228	1	compared	compare	VERB
bam-14214	228	2	to	to	ADP
bam-14214	228	3	irisin	irisin	VERB
bam-14214	228	4	injection	injection	NOUN
bam-14214	228	5	,	,	PUNCT
bam-14214	228	6	resistance	resistance	NOUN
bam-14214	228	7	exercise	exercise	NOUN
bam-14214	228	8	showed	show	VERB
bam-14214	228	9	no	no	DET
bam-14214	228	10	significant	significant	ADJ
bam-14214	228	11	difference	difference	NOUN
bam-14214	228	12	in	in	ADP
bam-14214	228	13	klotho	klotho	PROPN
bam-14214	228	14	or	or	CCONJ
bam-14214	228	15	hsp70	hsp70	NOUN
bam-14214	228	16	expression	expression	NOUN
bam-14214	228	17	(	(	PUNCT
bam-14214	228	18	ns	ns	ADJ
bam-14214	228	19	,	,	PUNCT
bam-14214	228	20	p>0.05	p>0.05	NOUN
bam-14214	228	21	)	)	PUNCT
bam-14214	228	22	,	,	PUNCT
bam-14214	228	23	while	while	SCONJ
bam-14214	228	24	irisin	irisin	ADJ
bam-14214	228	25	injection	injection	NOUN
bam-14214	228	26	significantly	significantly	ADV
bam-14214	228	27	increased	increase	VERB
bam-14214	228	28	both	both	CCONJ
bam-14214	228	29	klotho	klotho	NOUN
bam-14214	228	30	and	and	CCONJ
bam-14214	228	31	hsp70	hsp70	NOUN
bam-14214	228	32	expression	expression	NOUN
bam-14214	228	33	compared	compare	VERB
bam-14214	228	34	to	to	ADP
bam-14214	228	35	endurance	endurance	ADJ
bam-14214	228	36	exercise	exercise	NOUN
bam-14214	228	37	(	(	PUNCT
bam-14214	228	38	,	,	PUNCT
bam-14214	228	39	p<0.001	p<0.001	PROPN
bam-14214	228	40	)	)	PUNCT
bam-14214	228	41	.	.	PUNCT
bam-14214	229	1	(	(	PUNCT
bam-14214	229	2	e	e	NOUN
bam-14214	229	3	,	,	PUNCT
bam-14214	229	4	f	f	X
bam-14214	229	5	)	)	PUNCT
bam-14214	229	6	relative	relative	ADJ
bam-14214	229	7	mrna	mrna	NOUN
bam-14214	229	8	expression	expression	NOUN
bam-14214	229	9	of	of	ADP
bam-14214	229	10	klotho	klotho	PROPN
bam-14214	229	11	(	(	PUNCT
bam-14214	229	12	e	e	NOUN
bam-14214	229	13	)	)	PUNCT
bam-14214	229	14	and	and	CCONJ
bam-14214	229	15	hsp70	hsp70	NOUN
bam-14214	229	16	(	(	PUNCT
bam-14214	229	17	f	f	X
bam-14214	229	18	)	)	PUNCT
bam-14214	229	19	in	in	ADP
bam-14214	229	20	kidney	kidney	NOUN
bam-14214	229	21	tissue	tissue	NOUN
bam-14214	229	22	,	,	PUNCT
bam-14214	229	23	measured	measure	VERB
bam-14214	229	24	by	by	ADP
bam-14214	229	25	real	real	ADJ
bam-14214	229	26	-	-	PUNCT
bam-14214	229	27	time	time	NOUN
bam-14214	229	28	pcr	pcr	NOUN
bam-14214	229	29	and	and	CCONJ
bam-14214	229	30	normalized	normalize	VERB
bam-14214	229	31	to	to	PART
bam-14214	229	32	gapdh	gapdh	VERB
bam-14214	229	33	.	.	PUNCT
bam-14214	230	1	all	all	DET
bam-14214	230	2	intervention	intervention	NOUN
bam-14214	230	3	groups	group	NOUN
bam-14214	230	4	showed	show	VERB
bam-14214	230	5	significantly	significantly	ADV
bam-14214	230	6	higher	high	ADJ
bam-14214	230	7	expression	expression	NOUN
bam-14214	230	8	compared	compare	VERB
bam-14214	230	9	to	to	ADP
bam-14214	230	10	control	control	NOUN
bam-14214	230	11	(	(	PUNCT
bam-14214	230	12	p<0.001	p<0.001	PROPN
bam-14214	230	13	)	)	PUNCT
bam-14214	230	14	.	.	PUNCT
bam-14214	231	1	compared	compare	VERB
bam-14214	231	2	to	to	ADP
bam-14214	231	3	irisin	irisin	VERB
bam-14214	231	4	injection	injection	NOUN
bam-14214	231	5	,	,	PUNCT
bam-14214	231	6	resistance	resistance	NOUN
bam-14214	231	7	exercise	exercise	NOUN
bam-14214	231	8	significantly	significantly	ADV
bam-14214	231	9	increased	increase	VERB
bam-14214	231	10	klotho	klotho	ADJ
bam-14214	231	11	expression	expression	NOUN
bam-14214	231	12	(	(	PUNCT
bam-14214	231	13	*	*	NOUN
bam-14214	231	14	p<0.05	p<0.05	NOUN
bam-14214	231	15	)	)	PUNCT
bam-14214	231	16	,	,	PUNCT
bam-14214	231	17	while	while	SCONJ
bam-14214	231	18	irisin	irisin	ADJ
bam-14214	231	19	injection	injection	NOUN
bam-14214	231	20	showed	show	VERB
bam-14214	231	21	higher	high	ADJ
bam-14214	231	22	expression	expression	NOUN
bam-14214	231	23	than	than	ADP
bam-14214	231	24	endurance	endurance	NOUN
bam-14214	231	25	exercise	exercise	NOUN
bam-14214	231	26	p<0.01	p<0.01	PROPN
bam-14214	231	27	)	)	PUNCT
bam-14214	231	28	.	.	PUNCT
bam-14214	232	1	for	for	ADP
bam-14214	232	2	hsp70	hsp70	NOUN
bam-14214	232	3	,	,	PUNCT
bam-14214	232	4	irisin	irisin	VERB
bam-14214	232	5	injection	injection	NOUN
bam-14214	232	6	had	have	VERB
bam-14214	232	7	significantly	significantly	ADV
bam-14214	232	8	higher	high	ADJ
bam-14214	232	9	expression	expression	NOUN
bam-14214	232	10	than	than	ADP
bam-14214	232	11	endurance	endurance	ADJ
bam-14214	232	12	exercise	exercise	NOUN
bam-14214	232	13	(	(	PUNCT
bam-14214	232	14	*	*	NOUN
bam-14214	232	15	p<0.05	p<0.05	NOUN
bam-14214	232	16	)	)	PUNCT
bam-14214	232	17	,	,	PUNCT
bam-14214	232	18	but	but	CCONJ
bam-14214	232	19	no	no	DET
bam-14214	232	20	significant	significant	ADJ
bam-14214	232	21	difference	difference	NOUN
bam-14214	232	22	was	be	AUX
bam-14214	232	23	observed	observe	VERB
bam-14214	232	24	compared	compare	VERB
bam-14214	232	25	to	to	ADP
bam-14214	232	26	resistance	resistance	NOUN
bam-14214	232	27	exercise	exercise	NOUN
bam-14214	232	28	(	(	PUNCT
bam-14214	232	29	ns	ns	ADJ
bam-14214	232	30	,	,	PUNCT
bam-14214	232	31	p>0.05	p>0.05	NOUN
bam-14214	232	32	)	)	PUNCT
bam-14214	232	33	.	.	PUNCT
bam-14214	233	1	qpcr	qpcr	ADJ
bam-14214	233	2	data	datum	NOUN
bam-14214	233	3	(	(	PUNCT
bam-14214	233	4	e	e	NOUN
bam-14214	233	5	,	,	PUNCT
bam-14214	233	6	f	f	X
bam-14214	233	7	)	)	PUNCT
bam-14214	233	8	are	be	AUX
bam-14214	233	9	presented	present	VERB
bam-14214	233	10	as	as	ADP
bam-14214	233	11	mean±sd	mean±sd	PROPN
bam-14214	233	12	.	.	PUNCT
bam-14214	234	1	statistical	statistical	ADJ
bam-14214	234	2	significance	significance	NOUN
bam-14214	234	3	is	be	AUX
bam-14214	234	4	denoted	denote	VERB
bam-14214	234	5	as	as	SCONJ
bam-14214	234	6	follows	follow	VERB
bam-14214	234	7	:	:	PUNCT
bam-14214	234	8	*	*	PUNCT
bam-14214	234	9	*	*	PUNCT
bam-14214	234	10	*	*	PUNCT
bam-14214	234	11	p<0.001	p<0.001	ADJ
bam-14214	234	12	,	,	PUNCT
bam-14214	234	13	*	*	PUNCT
bam-14214	234	14	*	*	PUNCT
bam-14214	234	15	p<0.01	p<0.01	PROPN
bam-14214	234	16	,	,	PUNCT
bam-14214	234	17	p<0.05	p<0.05	NOUN
bam-14214	234	18	compared	compare	VERB
bam-14214	234	19	to	to	ADP
bam-14214	234	20	control	control	NOUN
bam-14214	234	21	;	;	PUNCT
bam-14214	234	22	#	#	NUM
bam-14214	234	23	p<0.05	p<0.05	NOUN
bam-14214	234	24	for	for	ADP
bam-14214	234	25	comparisons	comparison	NOUN
bam-14214	234	26	between	between	ADP
bam-14214	234	27	irisin	irisin	NOUN
bam-14214	234	28	injection	injection	NOUN
bam-14214	234	29	and	and	CCONJ
bam-14214	234	30	each	each	DET
bam-14214	234	31	exercise	exercise	NOUN
bam-14214	234	32	group	group	NOUN
bam-14214	234	33	;	;	PUNCT
bam-14214	234	34	ns	ns	NUM
bam-14214	234	35	indicates	indicate	VERB
bam-14214	234	36	no	no	DET
bam-14214	234	37	significant	significant	ADJ
bam-14214	234	38	difference	difference	NOUN
bam-14214	234	39	(	(	PUNCT
bam-14214	234	40	p>0.05	p>0.05	NOUN
bam-14214	234	41	)	)	PUNCT
bam-14214	234	42	.	.	PUNCT
bam-14214	235	1	19	19	NUM
bam-14214	235	2	figure	figure	NOUN
bam-14214	235	3	3	3	NUM
bam-14214	235	4	.	.	PUNCT
bam-14214	235	5	correlation	correlation	NOUN
bam-14214	235	6	analysis	analysis	NOUN
bam-14214	235	7	between	between	ADP
bam-14214	235	8	plasma	plasma	NOUN
bam-14214	235	9	irisin	irisin	NOUN
bam-14214	235	10	levels	level	NOUN
bam-14214	235	11	and	and	CCONJ
bam-14214	235	12	gene	gene	NOUN
bam-14214	235	13	expression	expression	NOUN
bam-14214	235	14	of	of	ADP
bam-14214	235	15	klotho	klotho	PROPN
bam-14214	235	16	and	and	CCONJ
bam-14214	235	17	hsp70	hsp70	NOUN
bam-14214	235	18	in	in	ADP
bam-14214	235	19	kidney	kidney	NOUN
bam-14214	235	20	tissue	tissue	NOUN
bam-14214	235	21	of	of	ADP
bam-14214	235	22	nmri	nmri	ADJ
bam-14214	235	23	mice	mouse	NOUN
bam-14214	235	24	.	.	PUNCT
bam-14214	236	1	scatter	scatter	NOUN
bam-14214	236	2	plot	plot	NOUN
bam-14214	236	3	showing	show	VERB
bam-14214	236	4	the	the	DET
bam-14214	236	5	relationship	relationship	NOUN
bam-14214	236	6	between	between	ADP
bam-14214	236	7	plasma	plasma	NOUN
bam-14214	236	8	irisin	irisin	NOUN
bam-14214	236	9	levels	level	NOUN
bam-14214	236	10	(	(	PUNCT
bam-14214	236	11	ng	ng	PROPN
bam-14214	236	12	/	/	SYM
bam-14214	236	13	ml	ml	PROPN
bam-14214	236	14	,	,	PUNCT
bam-14214	236	15	x	x	NOUN
bam-14214	236	16	-	-	NOUN
bam-14214	236	17	axis	axis	ADJ
bam-14214	236	18	)	)	PUNCT
bam-14214	236	19	and	and	CCONJ
bam-14214	236	20	relative	relative	ADJ
bam-14214	236	21	mrna	mrna	NOUN
bam-14214	236	22	expression	expression	NOUN
bam-14214	236	23	(	(	PUNCT
bam-14214	236	24	fold	fold	NOUN
bam-14214	236	25	change	change	NOUN
bam-14214	236	26	,	,	PUNCT
bam-14214	236	27	normalized	normalize	VERB
bam-14214	236	28	to	to	ADP
bam-14214	236	29	gapdh	gapdh	NOUN
bam-14214	236	30	,	,	PUNCT
bam-14214	236	31	measured	measure	VERB
bam-14214	236	32	by	by	ADP
bam-14214	236	33	real	real	ADJ
bam-14214	236	34	-	-	PUNCT
bam-14214	236	35	time	time	NOUN
bam-14214	236	36	pcr	pcr	PROPN
bam-14214	236	37	,	,	PUNCT
bam-14214	236	38	y	y	NOUN
bam-14214	236	39	-	-	PUNCT
bam-14214	236	40	axis	axis	NOUN
bam-14214	236	41	)	)	PUNCT
bam-14214	236	42	of	of	ADP
bam-14214	236	43	klotho	klotho	PROPN
bam-14214	236	44	(	(	PUNCT
bam-14214	236	45	red	red	ADJ
bam-14214	236	46	circles	circle	NOUN
bam-14214	236	47	)	)	PUNCT
bam-14214	236	48	and	and	CCONJ
bam-14214	236	49	hsp70	hsp70	NOUN
bam-14214	236	50	(	(	PUNCT
bam-14214	236	51	blue	blue	ADJ
bam-14214	236	52	squares	square	NOUN
bam-14214	236	53	)	)	PUNCT
bam-14214	236	54	.	.	PUNCT
bam-14214	237	1	a	a	DET
bam-14214	237	2	strong	strong	ADJ
bam-14214	237	3	positive	positive	ADJ
bam-14214	237	4	correlation	correlation	NOUN
bam-14214	237	5	was	be	AUX
bam-14214	237	6	observed	observe	VERB
bam-14214	237	7	between	between	ADP
bam-14214	237	8	plasma	plasma	NOUN
bam-14214	237	9	irisin	irisin	NOUN
bam-14214	237	10	levels	level	NOUN
bam-14214	237	11	and	and	CCONJ
bam-14214	237	12	klotho	klotho	VERB
bam-14214	237	13	expression	expression	NOUN
bam-14214	237	14	(	(	PUNCT
bam-14214	237	15	r	r	NOUN
bam-14214	237	16	=	=	SYM
bam-14214	237	17	0.9498	0.9498	NUM
bam-14214	237	18	,	,	PUNCT
bam-14214	237	19	p<0.0001	p<0.0001	NOUN
bam-14214	237	20	)	)	PUNCT
bam-14214	237	21	,	,	PUNCT
bam-14214	237	22	while	while	SCONJ
bam-14214	237	23	a	a	DET
bam-14214	237	24	moderate	moderate	ADJ
bam-14214	237	25	positive	positive	ADJ
bam-14214	237	26	correlation	correlation	NOUN
bam-14214	237	27	was	be	AUX
bam-14214	237	28	found	find	VERB
bam-14214	237	29	for	for	ADP
bam-14214	237	30	hsp70	hsp70	NOUN
bam-14214	237	31	expression	expression	NOUN
bam-14214	237	32	(	(	PUNCT
bam-14214	237	33	r	r	NOUN
bam-14214	237	34	=	=	SYM
bam-14214	237	35	0.7511	0.7511	NUM
bam-14214	237	36	,	,	PUNCT
bam-14214	237	37	p<0.003	p<0.003	NOUN
bam-14214	237	38	)	)	PUNCT
bam-14214	237	39	,	,	PUNCT
bam-14214	237	40	as	as	SCONJ
bam-14214	237	41	determined	determine	VERB
bam-14214	237	42	by	by	ADP
bam-14214	237	43	a	a	DET
bam-14214	237	44	two	two	NUM
bam-14214	237	45	-	-	PUNCT
bam-14214	237	46	tailed	tail	VERB
bam-14214	237	47	pearson	pearson	NOUN
bam-14214	237	48	correlation	correlation	NOUN
bam-14214	237	49	test	test	NOUN
bam-14214	237	50	.	.	PUNCT
bam-14214	238	1	20	20	NUM
bam-14214	238	2	figure	figure	NOUN
bam-14214	238	3	4	4	NUM
bam-14214	238	4	.	.	PUNCT
bam-14214	239	1	kaplan	kaplan	PROPN
bam-14214	239	2	–	–	PUNCT
bam-14214	239	3	meier	meier	PROPN
bam-14214	239	4	survival	survival	NOUN
bam-14214	239	5	curves	curve	NOUN
bam-14214	239	6	for	for	ADP
bam-14214	239	7	control	control	NOUN
bam-14214	239	8	,	,	PUNCT
bam-14214	239	9	endurance	endurance	NOUN
bam-14214	239	10	exercise	exercise	NOUN
bam-14214	239	11	,	,	PUNCT
bam-14214	239	12	resistance	resistance	NOUN
bam-14214	239	13	exercise	exercise	NOUN
bam-14214	239	14	,	,	PUNCT
bam-14214	239	15	and	and	CCONJ
bam-14214	239	16	irisin	irisin	VERB
bam-14214	239	17	injection	injection	NOUN
bam-14214	239	18	groups	group	NOUN
bam-14214	239	19	over	over	ADP
bam-14214	239	20	a	a	DET
bam-14214	239	21	20	20	NUM
bam-14214	239	22	-	-	PUNCT
bam-14214	239	23	month	month	NOUN
bam-14214	239	24	period	period	NOUN
bam-14214	239	25	.	.	PUNCT
bam-14214	240	1	male	male	ADJ
bam-14214	240	2	nmri	nmri	ADJ
bam-14214	240	3	mice	mouse	NOUN
bam-14214	240	4	(	(	PUNCT
bam-14214	240	5	n	n	NOUN
bam-14214	240	6	=	=	SYM
bam-14214	240	7	12	12	NUM
bam-14214	240	8	per	per	ADP
bam-14214	240	9	group	group	NOUN
bam-14214	240	10	)	)	PUNCT
bam-14214	240	11	were	be	AUX
bam-14214	240	12	monitored	monitor	VERB
bam-14214	240	13	daily	daily	ADV
bam-14214	240	14	following	follow	VERB
bam-14214	240	15	an	an	DET
bam-14214	240	16	8	8	NUM
bam-14214	240	17	-	-	PUNCT
bam-14214	240	18	week	week	NOUN
bam-14214	240	19	intervention	intervention	NOUN
bam-14214	240	20	.	.	PUNCT
bam-14214	241	1	the	the	DET
bam-14214	241	2	control	control	PROPN
bam-14214	241	3	group	group	NOUN
bam-14214	241	4	(	(	PUNCT
bam-14214	241	5	blue	blue	ADJ
bam-14214	241	6	)	)	PUNCT
bam-14214	241	7	showed	show	VERB
bam-14214	241	8	the	the	DET
bam-14214	241	9	highest	high	ADJ
bam-14214	241	10	mortality	mortality	NOUN
bam-14214	241	11	(	(	PUNCT
bam-14214	241	12	8	8	NUM
bam-14214	241	13	deaths	death	NOUN
bam-14214	241	14	)	)	PUNCT
bam-14214	241	15	,	,	PUNCT
bam-14214	241	16	while	while	SCONJ
bam-14214	241	17	the	the	DET
bam-14214	241	18	resistance	resistance	NOUN
bam-14214	241	19	exercise	exercise	NOUN
bam-14214	241	20	group	group	NOUN
bam-14214	241	21	(	(	PUNCT
bam-14214	241	22	red	red	PROPN
bam-14214	241	23	)	)	PUNCT
bam-14214	241	24	had	have	VERB
bam-14214	241	25	the	the	DET
bam-14214	241	26	lowest	low	ADJ
bam-14214	241	27	(	(	PUNCT
bam-14214	241	28	3	3	NUM
bam-14214	241	29	deaths	death	NOUN
bam-14214	241	30	)	)	PUNCT
bam-14214	241	31	.	.	PUNCT
bam-14214	242	1	the	the	DET
bam-14214	242	2	irisin	irisin	NOUN
bam-14214	242	3	injection	injection	NOUN
bam-14214	242	4	(	(	PUNCT
bam-14214	242	5	green	green	ADJ
bam-14214	242	6	)	)	PUNCT
bam-14214	242	7	and	and	CCONJ
bam-14214	242	8	endurance	endurance	NOUN
bam-14214	242	9	exercise	exercise	NOUN
bam-14214	242	10	(	(	PUNCT
bam-14214	242	11	purple	purple	ADJ
bam-14214	242	12	)	)	PUNCT
bam-14214	242	13	groups	group	NOUN
bam-14214	242	14	exhibited	exhibit	VERB
bam-14214	242	15	4	4	NUM
bam-14214	242	16	and	and	CCONJ
bam-14214	242	17	5	5	NUM
bam-14214	242	18	deaths	death	NOUN
bam-14214	242	19	,	,	PUNCT
bam-14214	242	20	respectively	respectively	ADV
bam-14214	242	21	.	.	PUNCT
bam-14214	243	1	the	the	DET
bam-14214	243	2	median	median	ADJ
bam-14214	243	3	survival	survival	NOUN
bam-14214	243	4	time	time	NOUN
bam-14214	243	5	was	be	AUX
bam-14214	243	6	reached	reach	VERB
bam-14214	243	7	only	only	ADV
bam-14214	243	8	in	in	ADP
bam-14214	243	9	the	the	DET
bam-14214	243	10	control	control	NOUN
bam-14214	243	11	group	group	NOUN
bam-14214	243	12	(	(	PUNCT
bam-14214	243	13	480	480	NUM
bam-14214	243	14	days	day	NOUN
bam-14214	243	15	)	)	PUNCT
bam-14214	243	16	,	,	PUNCT
bam-14214	243	17	whereas	whereas	SCONJ
bam-14214	243	18	it	it	PRON
bam-14214	243	19	remained	remain	VERB
bam-14214	243	20	undefined	undefined	ADJ
bam-14214	243	21	in	in	ADP
bam-14214	243	22	all	all	DET
bam-14214	243	23	intervention	intervention	NOUN
bam-14214	243	24	groups	group	NOUN
bam-14214	243	25	.	.	PUNCT
bam-14214	244	1	statistical	statistical	ADJ
bam-14214	244	2	analysis	analysis	NOUN
bam-14214	244	3	using	use	VERB
bam-14214	244	4	the	the	DET
bam-14214	244	5	log	log	NOUN
bam-14214	244	6	-	-	PUNCT
bam-14214	244	7	rank	rank	NOUN
bam-14214	244	8	(	(	PUNCT
bam-14214	244	9	mantel	mantel	NOUN
bam-14214	244	10	–	–	PUNCT
bam-14214	244	11	cox	cox	NOUN
bam-14214	244	12	)	)	PUNCT
bam-14214	244	13	test	test	NOUN
bam-14214	244	14	did	do	AUX
bam-14214	244	15	not	not	PART
bam-14214	244	16	reveal	reveal	VERB
bam-14214	244	17	significant	significant	ADJ
bam-14214	244	18	differences	difference	NOUN
bam-14214	244	19	among	among	ADP
bam-14214	244	20	the	the	DET
bam-14214	244	21	groups	group	NOUN
bam-14214	244	22	(	(	PUNCT
bam-14214	244	23	p=0.0927	p=0.0927	NUM
bam-14214	244	24	)	)	PUNCT
bam-14214	244	25	,	,	PUNCT
bam-14214	244	26	but	but	CCONJ
bam-14214	244	27	the	the	DET
bam-14214	244	28	log	log	NOUN
bam-14214	244	29	-	-	PUNCT
bam-14214	244	30	rank	rank	NOUN
bam-14214	244	31	test	test	NOUN
bam-14214	244	32	for	for	ADP
bam-14214	244	33	trend	trend	NOUN
bam-14214	244	34	indicated	indicate	VERB
bam-14214	244	35	a	a	DET
bam-14214	244	36	significant	significant	ADJ
bam-14214	244	37	survival	survival	NOUN
bam-14214	244	38	trend	trend	NOUN
bam-14214	244	39	favoring	favor	VERB
bam-14214	244	40	the	the	DET
bam-14214	244	41	intervention	intervention	NOUN
bam-14214	244	42	groups	group	NOUN
bam-14214	244	43	(	(	PUNCT
bam-14214	244	44	p=0.0423	p=0.0423	PROPN
bam-14214	244	45	)	)	PUNCT
bam-14214	244	46	.	.	PUNCT
bam-14214	245	1	these	these	DET
bam-14214	245	2	results	result	NOUN
bam-14214	245	3	suggest	suggest	VERB
bam-14214	245	4	a	a	DET
bam-14214	245	5	potential	potential	ADJ
bam-14214	245	6	long	long	ADJ
bam-14214	245	7	-	-	PUNCT
bam-14214	245	8	term	term	NOUN
bam-14214	245	9	benefit	benefit	NOUN
bam-14214	245	10	of	of	ADP
bam-14214	245	11	early	early	ADJ
bam-14214	245	12	-	-	PUNCT
bam-14214	245	13	life	life	NOUN
bam-14214	245	14	physical	physical	ADJ
bam-14214	245	15	interventions	intervention	NOUN
bam-14214	245	16	and	and	CCONJ
bam-14214	245	17	irisin	irisin	VERB
bam-14214	245	18	administration	administration	NOUN
bam-14214	245	19	on	on	ADP
bam-14214	245	20	survival	survival	NOUN
bam-14214	245	21	.	.	PUNCT