id	sid	tid	token	lemma	pos
bam-1791	1	1	microsoft	microsoft	PROPN
bam-1791	1	2	word	word	NOUN
bam-1791	1	3	12ejtmbam22_1&2	12ejtmbam22_1&2	NUM
bam-1791	1	4	_	_	NOUN
bam-1791	1	5	19	19	NUM
bam-1791	1	6	-	-	SYM
bam-1791	1	7	38	38	NUM
bam-1791	1	8	ix	ix	ADP
bam-1791	1	9	iim	iim	NOUN
bam-1791	1	10	abstracts.doc	abstracts.doc	PROPN
bam-1791	1	11	ix	ix	ADP
bam-1791	1	12	iim	iim	PROPN
bam-1791	1	13	meeting	meeting	NOUN
bam-1791	1	14	,	,	PUNCT
bam-1791	1	15	acaya	acaya	NOUN
bam-1791	1	16	(	(	PUNCT
bam-1791	1	17	lecce	lecce	PROPN
bam-1791	1	18	)	)	PUNCT
bam-1791	1	19	,	,	PUNCT
bam-1791	1	20	october	october	PROPN
bam-1791	1	21	12	12	NUM
bam-1791	1	22	-	-	SYM
bam-1791	1	23	14	14	NUM
bam-1791	1	24	,	,	PUNCT
bam-1791	1	25	2012	2012	NUM
bam-1791	1	26	european	european	PROPN
bam-1791	1	27	journal	journal	PROPN
bam-1791	1	28	translational	translational	ADJ
bam-1791	1	29	myology	myology	NOUN
bam-1791	1	30	basic	basic	ADJ
bam-1791	1	31	applied	apply	VERB
bam-1791	1	32	myology	myology	NOUN
bam-1791	1	33	2012	2012	NUM
bam-1791	1	34	;	;	PUNCT
bam-1791	1	35	22(1&2	22(1&2	NUM
bam-1791	1	36	):	):	PUNCT
bam-1791	1	37	xxx	xxx	NOUN
bam-1791	1	38	-	-	PUNCT
bam-1791	1	39	xxx	xxx	NOUN
bam-1791	1	40	19	19	NUM
bam-1791	1	41	ix	ix	ADP
bam-1791	1	42	annual	annual	ADJ
bam-1791	1	43	meeting	meeting	NOUN
bam-1791	1	44	12	12	NUM
bam-1791	1	45	-	-	SYM
bam-1791	1	46	14	14	NUM
bam-1791	1	47	october	october	PROPN
bam-1791	1	48	2012	2012	NUM
bam-1791	1	49	doubletree	doubletree	NOUN
bam-1791	1	50	by	by	ADP
bam-1791	1	51	hilton	hilton	PROPN
bam-1791	1	52	acaya	acaya	PROPN
bam-1791	1	53	golf	golf	NOUN
bam-1791	1	54	resort	resort	NOUN
bam-1791	1	55	,	,	PUNCT
bam-1791	1	56	acaya	acaya	NOUN
bam-1791	1	57	,	,	PUNCT
bam-1791	1	58	lecce	lecce	ADJ
bam-1791	1	59	abstracts	abstract	NOUN
bam-1791	1	60	sessions	session	NOUN
bam-1791	1	61	:	:	PUNCT
bam-1791	1	62	muscle	muscle	NOUN
bam-1791	1	63	differentiation	differentiation	NOUN
bam-1791	1	64	and	and	CCONJ
bam-1791	1	65	regulatory	regulatory	ADJ
bam-1791	1	66	mechanisms	mechanism	NOUN
bam-1791	1	67	(	(	PUNCT
bam-1791	1	68	pp	pp	ADP
bam-1791	1	69	20	20	NUM
bam-1791	1	70	-	-	SYM
bam-1791	1	71	22	22	NUM
bam-1791	1	72	)	)	PUNCT
bam-1791	1	73	satellite	satellite	NOUN
bam-1791	1	74	cells	cell	NOUN
bam-1791	1	75	and	and	CCONJ
bam-1791	1	76	muscle	muscle	NOUN
bam-1791	1	77	regeneration	regeneration	NOUN
bam-1791	1	78	(	(	PUNCT
bam-1791	1	79	pp	pp	ADP
bam-1791	1	80	22	22	NUM
bam-1791	1	81	-	-	SYM
bam-1791	1	82	25	25	NUM
bam-1791	1	83	)	)	PUNCT
bam-1791	1	84	muscular	muscular	ADJ
bam-1791	1	85	dystrophies	dystrophy	NOUN
bam-1791	1	86	(	(	PUNCT
bam-1791	1	87	pp	pp	PROPN
bam-1791	1	88	25	25	NUM
bam-1791	1	89	-	-	SYM
bam-1791	1	90	28	28	NUM
bam-1791	1	91	)	)	PUNCT
bam-1791	2	1	e	e	NOUN
bam-1791	2	2	-	-	NOUN
bam-1791	2	3	c	c	ADJ
bam-1791	2	4	coupling	coupling	NOUN
bam-1791	2	5	in	in	ADP
bam-1791	2	6	health	health	NOUN
bam-1791	2	7	and	and	CCONJ
bam-1791	2	8	diseases	disease	NOUN
bam-1791	2	9	(	(	PUNCT
bam-1791	2	10	pp	pp	ADV
bam-1791	2	11	28	28	NUM
bam-1791	2	12	-	-	SYM
bam-1791	2	13	30	30	NUM
bam-1791	2	14	)	)	PUNCT
bam-1791	2	15	myopathies	myopathy	NOUN
bam-1791	2	16	and	and	CCONJ
bam-1791	2	17	neuromuscular	neuromuscular	ADJ
bam-1791	2	18	diseases	disease	NOUN
bam-1791	2	19	(	(	PUNCT
bam-1791	2	20	pp	pp	ADP
bam-1791	2	21	30	30	NUM
bam-1791	2	22	-	-	SYM
bam-1791	2	23	33	33	NUM
bam-1791	2	24	)	)	PUNCT
bam-1791	2	25	muscle	muscle	NOUN
bam-1791	2	26	atrophy	atrophy	NOUN
bam-1791	2	27	and	and	CCONJ
bam-1791	2	28	aging	aging	NOUN
bam-1791	2	29	(	(	PUNCT
bam-1791	2	30	pp	pp	PROPN
bam-1791	2	31	34	34	NUM
bam-1791	2	32	-	-	SYM
bam-1791	2	33	36	36	NUM
bam-1791	2	34	)	)	PUNCT
bam-1791	2	35	cachexia	cachexia	NOUN
bam-1791	2	36	and	and	CCONJ
bam-1791	2	37	muscle	muscle	NOUN
bam-1791	2	38	wasting	waste	VERB
bam-1791	2	39	(	(	PUNCT
bam-1791	2	40	pp	pp	ADP
bam-1791	2	41	37	37	NUM
bam-1791	2	42	-	-	SYM
bam-1791	2	43	38	38	NUM
bam-1791	2	44	)	)	PUNCT
bam-1791	2	45	scientific	scientific	ADJ
bam-1791	2	46	committee	committee	NOUN
bam-1791	2	47	:	:	PUNCT
bam-1791	2	48	musarò	musarò	NOUN
bam-1791	2	49	a	a	PRON
bam-1791	2	50	,	,	PUNCT
bam-1791	2	51	sandri	sandri	PROPN
bam-1791	2	52	m	m	PROPN
bam-1791	2	53	,	,	PUNCT
bam-1791	2	54	rossi	rossi	ADJ
bam-1791	2	55	d	d	X
bam-1791	2	56	,	,	PUNCT
bam-1791	2	57	sampaolesi	sampaolesi	PROPN
bam-1791	2	58	m	m	PROPN
bam-1791	2	59	,	,	PUNCT
bam-1791	2	60	danieli	danieli	PROPN
bam-1791	2	61	d	d	NOUN
bam-1791	2	62	,	,	PUNCT
bam-1791	2	63	vitiello	vitiello	PROPN
bam-1791	2	64	l	l	NOUN
bam-1791	2	65	,	,	PUNCT
bam-1791	2	66	sorci	sorci	VERB
bam-1791	2	67	g	g	PROPN
bam-1791	2	68	,	,	PUNCT
bam-1791	2	69	bagni	bagni	PROPN
bam-1791	2	70	ma	ma	PROPN
bam-1791	2	71	,	,	PUNCT
bam-1791	2	72	lorenzon	lorenzon	PROPN
bam-1791	2	73	p	p	PROPN
bam-1791	2	74	,	,	PUNCT
bam-1791	2	75	fanò	fanò	NOUN
bam-1791	2	76	g	g	PROPN
bam-1791	2	77	,	,	PUNCT
bam-1791	3	1	bottinelli	bottinelli	PROPN
bam-1791	3	2	r.	r.	PROPN
bam-1791	3	3	con	con	PROPN
bam-1791	3	4	il	il	PROPN
bam-1791	3	5	supporto	supporto	PROPN
bam-1791	3	6	e	e	PROPN
bam-1791	3	7	contributo	contributo	PROPN
bam-1791	3	8	scientifico	scientifico	PROPN
bam-1791	3	9	di	di	PROPN
bam-1791	3	10	:	:	PUNCT
bam-1791	3	11	ix	ix	PROPN
bam-1791	3	12	iim	iim	PROPN
bam-1791	3	13	meeting	meeting	NOUN
bam-1791	3	14	,	,	PUNCT
bam-1791	3	15	acaya	acaya	NOUN
bam-1791	3	16	(	(	PUNCT
bam-1791	3	17	lecce	lecce	PROPN
bam-1791	3	18	)	)	PUNCT
bam-1791	3	19	,	,	PUNCT
bam-1791	3	20	october	october	PROPN
bam-1791	3	21	12	12	NUM
bam-1791	3	22	-	-	SYM
bam-1791	3	23	14	14	NUM
bam-1791	3	24	,	,	PUNCT
bam-1791	3	25	2012	2012	NUM
bam-1791	3	26	european	european	PROPN
bam-1791	3	27	journal	journal	PROPN
bam-1791	3	28	translational	translational	ADJ
bam-1791	3	29	myology	myology	NOUN
bam-1791	3	30	basic	basic	ADJ
bam-1791	3	31	applied	apply	VERB
bam-1791	3	32	myology	myology	NOUN
bam-1791	3	33	2012	2012	NUM
bam-1791	3	34	;	;	PUNCT
bam-1791	3	35	22(1&2	22(1&2	NUM
bam-1791	3	36	):	):	PUNCT
bam-1791	3	37	xxx	xxx	NOUN
bam-1791	3	38	-	-	PUNCT
bam-1791	3	39	xxx	xxx	NOUN
bam-1791	3	40	20	20	NUM
bam-1791	3	41	session	session	NOUN
bam-1791	3	42	1	1	NUM
bam-1791	3	43	muscle	muscle	NOUN
bam-1791	3	44	differentiation	differentiation	NOUN
bam-1791	3	45	and	and	CCONJ
bam-1791	3	46	regulatory	regulatory	ADJ
bam-1791	3	47	mechanisms	mechanism	NOUN
bam-1791	3	48	1	1	NUM
bam-1791	3	49	.	.	PUNCT
bam-1791	3	50	myod	myod	PROPN
bam-1791	3	51	regulates	regulate	VERB
bam-1791	3	52	p57kip2	p57kip2	NOUN
bam-1791	3	53	expression	expression	NOUN
bam-1791	3	54	by	by	ADP
bam-1791	3	55	interacting	interact	VERB
bam-1791	3	56	with	with	ADP
bam-1791	3	57	a	a	DET
bam-1791	3	58	distant	distant	ADJ
bam-1791	3	59	cis	cis	NOUN
bam-1791	3	60	-	-	PUNCT
bam-1791	3	61	element	element	NOUN
bam-1791	3	62	and	and	CCONJ
bam-1791	3	63	modifying	modify	VERB
bam-1791	3	64	a	a	DET
bam-1791	3	65	higher	high	ADJ
bam-1791	3	66	-	-	PUNCT
bam-1791	3	67	order	order	NOUN
bam-1791	3	68	chromatin	chromatin	NOUN
bam-1791	3	69	structure	structure	NOUN
bam-1791	3	70	c.	c.	PROPN
bam-1791	3	71	battistelli	battistelli	PROPN
bam-1791	3	72	,	,	PUNCT
bam-1791	3	73	a.	a.	NOUN
bam-1791	3	74	busanello	busanello	PROPN
bam-1791	3	75	,	,	PUNCT
bam-1791	3	76	m.	m.	NOUN
bam-1791	3	77	carbone	carbone	NOUN
bam-1791	3	78	,	,	PUNCT
bam-1791	3	79	c.	c.	PROPN
bam-1791	3	80	mostocotto	mostocotto	PROPN
bam-1791	3	81	,	,	PUNCT
bam-1791	3	82	r.	r.	PROPN
bam-1791	3	83	maione	maione	PROPN
bam-1791	3	84	istituto	istituto	PROPN
bam-1791	3	85	pasteur	pasteur	PROPN
bam-1791	3	86	-	-	PUNCT
bam-1791	3	87	fondazione	fondazione	PROPN
bam-1791	3	88	cenci	cenci	NOUN
bam-1791	3	89	bolognetti	bolognetti	NOUN
bam-1791	3	90	,	,	PUNCT
bam-1791	3	91	dept	dept	ADJ
bam-1791	3	92	cellular	cellular	ADJ
bam-1791	3	93	biotechnologies	biotechnology	NOUN
bam-1791	3	94	and	and	CCONJ
bam-1791	3	95	haematology	haematology	NOUN
bam-1791	3	96	,	,	PUNCT
bam-1791	3	97	sapienza	sapienza	PROPN
bam-1791	3	98	univ	univ	PROPN
bam-1791	3	99	.	.	PUNCT
bam-1791	4	1	of	of	ADP
bam-1791	4	2	rome	rome	PROPN
bam-1791	4	3	,	,	PUNCT
bam-1791	4	4	italy	italy	PROPN
bam-1791	4	5	the	the	DET
bam-1791	4	6	bhlh	bhlh	NOUN
bam-1791	4	7	transcription	transcription	NOUN
bam-1791	4	8	factor	factor	NOUN
bam-1791	4	9	myod	myod	NOUN
bam-1791	4	10	,	,	PUNCT
bam-1791	4	11	the	the	DET
bam-1791	4	12	prototypical	prototypical	ADJ
bam-1791	4	13	master	master	NOUN
bam-1791	4	14	regulator	regulator	NOUN
bam-1791	4	15	of	of	ADP
bam-1791	4	16	differentiation	differentiation	NOUN
bam-1791	4	17	,	,	PUNCT
bam-1791	4	18	directs	direct	VERB
bam-1791	4	19	a	a	DET
bam-1791	4	20	complex	complex	ADJ
bam-1791	4	21	program	program	NOUN
bam-1791	4	22	of	of	ADP
bam-1791	4	23	gene	gene	NOUN
bam-1791	4	24	expression	expression	NOUN
bam-1791	4	25	during	during	ADP
bam-1791	4	26	skeletal	skeletal	ADJ
bam-1791	4	27	myogenesis	myogenesis	NOUN
bam-1791	4	28	.	.	PUNCT
bam-1791	5	1	the	the	DET
bam-1791	5	2	up	up	ADJ
bam-1791	5	3	-	-	PUNCT
bam-1791	5	4	regulation	regulation	NOUN
bam-1791	5	5	of	of	ADP
bam-1791	5	6	the	the	DET
bam-1791	5	7	cdk	cdk	NOUN
bam-1791	5	8	inhibitor	inhibitor	NOUN
bam-1791	5	9	p57kip2	p57kip2	VERB
bam-1791	5	10	plays	play	VERB
bam-1791	5	11	a	a	DET
bam-1791	5	12	critical	critical	ADJ
bam-1791	5	13	role	role	NOUN
bam-1791	5	14	in	in	ADP
bam-1791	5	15	coordinating	coordinate	VERB
bam-1791	5	16	differentiation	differentiation	NOUN
bam-1791	5	17	and	and	CCONJ
bam-1791	5	18	growth	growth	NOUN
bam-1791	5	19	arrest	arrest	NOUN
bam-1791	5	20	during	during	ADP
bam-1791	5	21	muscle	muscle	NOUN
bam-1791	5	22	development	development	NOUN
bam-1791	5	23	as	as	ADV
bam-1791	5	24	well	well	ADV
bam-1791	5	25	as	as	ADP
bam-1791	5	26	in	in	ADP
bam-1791	5	27	other	other	ADJ
bam-1791	5	28	tissues	tissue	NOUN
bam-1791	5	29	.	.	PUNCT
bam-1791	6	1	p57kip2	p57kip2	VERB
bam-1791	6	2	displays	display	VERB
bam-1791	6	3	a	a	DET
bam-1791	6	4	highly	highly	ADV
bam-1791	6	5	specific	specific	ADJ
bam-1791	6	6	expression	expression	NOUN
bam-1791	6	7	pattern	pattern	NOUN
bam-1791	6	8	and	and	CCONJ
bam-1791	6	9	is	be	AUX
bam-1791	6	10	subject	subject	ADJ
bam-1791	6	11	to	to	ADP
bam-1791	6	12	a	a	DET
bam-1791	6	13	complex	complex	ADJ
bam-1791	6	14	epigenetic	epigenetic	ADJ
bam-1791	6	15	control	control	NOUN
bam-1791	6	16	driving	drive	VERB
bam-1791	6	17	the	the	DET
bam-1791	6	18	imprinting	imprinting	NOUN
bam-1791	6	19	of	of	ADP
bam-1791	6	20	the	the	DET
bam-1791	6	21	paternal	paternal	ADJ
bam-1791	6	22	allele	allele	NOUN
bam-1791	6	23	.	.	PUNCT
bam-1791	7	1	however	however	ADV
bam-1791	7	2	,	,	PUNCT
bam-1791	7	3	the	the	DET
bam-1791	7	4	regulatory	regulatory	ADJ
bam-1791	7	5	mechanisms	mechanism	NOUN
bam-1791	7	6	governing	govern	VERB
bam-1791	7	7	its	its	PRON
bam-1791	7	8	expression	expression	NOUN
bam-1791	7	9	during	during	ADP
bam-1791	7	10	development	development	NOUN
bam-1791	7	11	are	be	AUX
bam-1791	7	12	still	still	ADV
bam-1791	7	13	poorly	poorly	ADV
bam-1791	7	14	understood	understand	VERB
bam-1791	7	15	.	.	PUNCT
bam-1791	8	1	we	we	PRON
bam-1791	8	2	have	have	AUX
bam-1791	8	3	identified	identify	VERB
bam-1791	8	4	an	an	DET
bam-1791	8	5	unexpected	unexpected	ADJ
bam-1791	8	6	mechanism	mechanism	NOUN
bam-1791	8	7	by	by	ADP
bam-1791	8	8	which	which	PRON
bam-1791	8	9	myod	myod	NOUN
bam-1791	8	10	regulates	regulate	VERB
bam-1791	8	11	p57kip2	p57kip2	VERB
bam-1791	8	12	transcription	transcription	NOUN
bam-1791	8	13	in	in	ADP
bam-1791	8	14	differentiating	differentiate	VERB
bam-1791	8	15	muscle	muscle	NOUN
bam-1791	8	16	cells	cell	NOUN
bam-1791	8	17	.	.	PUNCT
bam-1791	9	1	we	we	PRON
bam-1791	9	2	show	show	VERB
bam-1791	9	3	that	that	SCONJ
bam-1791	9	4	the	the	DET
bam-1791	9	5	induction	induction	NOUN
bam-1791	9	6	of	of	ADP
bam-1791	9	7	p57kip2	p57kip2	NOUN
bam-1791	9	8	requires	require	VERB
bam-1791	9	9	myod	myod	NOUN
bam-1791	9	10	binding	bind	VERB
bam-1791	9	11	to	to	ADP
bam-1791	9	12	a	a	DET
bam-1791	9	13	long	long	ADJ
bam-1791	9	14	-	-	PUNCT
bam-1791	9	15	distance	distance	NOUN
bam-1791	9	16	element	element	NOUN
bam-1791	9	17	located	locate	VERB
bam-1791	9	18	within	within	ADP
bam-1791	9	19	the	the	DET
bam-1791	9	20	imprinting	imprinting	ADJ
bam-1791	9	21	control	control	NOUN
bam-1791	9	22	region	region	NOUN
bam-1791	9	23	kvdmr1	kvdmr1	PROPN
bam-1791	9	24	and	and	CCONJ
bam-1791	9	25	the	the	DET
bam-1791	9	26	consequent	consequent	ADJ
bam-1791	9	27	release	release	NOUN
bam-1791	9	28	of	of	ADP
bam-1791	9	29	a	a	DET
bam-1791	9	30	chromatin	chromatin	NOUN
bam-1791	9	31	loop	loop	NOUN
bam-1791	9	32	involving	involve	VERB
bam-1791	9	33	p57kip2	p57kip2	NOUN
bam-1791	9	34	promoter	promoter	NOUN
bam-1791	9	35	.	.	PUNCT
bam-1791	10	1	we	we	PRON
bam-1791	10	2	also	also	ADV
bam-1791	10	3	show	show	VERB
bam-1791	10	4	that	that	SCONJ
bam-1791	10	5	differentiation	differentiation	NOUN
bam-1791	10	6	-	-	PUNCT
bam-1791	10	7	dependent	dependent	ADJ
bam-1791	10	8	regulation	regulation	NOUN
bam-1791	10	9	of	of	ADP
bam-1791	10	10	p57kip2	p57kip2	NOUN
bam-1791	10	11	,	,	PUNCT
bam-1791	10	12	while	while	SCONJ
bam-1791	10	13	involving	involve	VERB
bam-1791	10	14	a	a	DET
bam-1791	10	15	region	region	NOUN
bam-1791	10	16	implicated	implicate	VERB
bam-1791	10	17	in	in	ADP
bam-1791	10	18	the	the	DET
bam-1791	10	19	imprinting	imprint	VERB
bam-1791	10	20	process	process	NOUN
bam-1791	10	21	,	,	PUNCT
bam-1791	10	22	is	be	AUX
bam-1791	10	23	distinct	distinct	ADJ
bam-1791	10	24	and	and	CCONJ
bam-1791	10	25	hierarchically	hierarchically	ADV
bam-1791	10	26	subordinated	subordinate	VERB
bam-1791	10	27	to	to	ADP
bam-1791	10	28	the	the	DET
bam-1791	10	29	imprinting	imprint	VERB
bam-1791	10	30	control	control	NOUN
bam-1791	10	31	.	.	PUNCT
bam-1791	11	1	these	these	DET
bam-1791	11	2	findings	finding	NOUN
bam-1791	11	3	highlight	highlight	VERB
bam-1791	11	4	a	a	DET
bam-1791	11	5	novel	novel	ADJ
bam-1791	11	6	mechanism	mechanism	NOUN
bam-1791	11	7	,	,	PUNCT
bam-1791	11	8	involving	involve	VERB
bam-1791	11	9	the	the	DET
bam-1791	11	10	modification	modification	NOUN
bam-1791	11	11	of	of	ADP
bam-1791	11	12	higher	high	ADJ
bam-1791	11	13	order	order	NOUN
bam-1791	11	14	chromatin	chromatin	NOUN
bam-1791	11	15	structures	structure	NOUN
bam-1791	11	16	,	,	PUNCT
bam-1791	11	17	by	by	ADP
bam-1791	11	18	which	which	PRON
bam-1791	11	19	myod	myod	NOUN
bam-1791	11	20	regulates	regulate	VERB
bam-1791	11	21	gene	gene	NOUN
bam-1791	11	22	expression	expression	NOUN
bam-1791	11	23	.	.	PUNCT
bam-1791	12	1	our	our	PRON
bam-1791	12	2	results	result	NOUN
bam-1791	12	3	also	also	ADV
bam-1791	12	4	suggest	suggest	VERB
bam-1791	12	5	that	that	SCONJ
bam-1791	12	6	chromatin	chromatin	NOUN
bam-1791	12	7	folding	folding	NOUN
bam-1791	12	8	mediated	mediate	VERB
bam-1791	12	9	by	by	ADP
bam-1791	12	10	kvdmr1	kvdmr1	PROPN
bam-1791	12	11	could	could	AUX
bam-1791	12	12	account	account	VERB
bam-1791	12	13	for	for	ADP
bam-1791	12	14	the	the	DET
bam-1791	12	15	highly	highly	ADV
bam-1791	12	16	restricted	restricted	ADJ
bam-1791	12	17	expression	expression	NOUN
bam-1791	12	18	of	of	ADP
bam-1791	12	19	p57kip2	p57kip2	NOUN
bam-1791	12	20	during	during	ADP
bam-1791	12	21	development	development	NOUN
bam-1791	12	22	and	and	CCONJ
bam-1791	12	23	,	,	PUNCT
bam-1791	12	24	possibly	possibly	ADV
bam-1791	12	25	,	,	PUNCT
bam-1791	12	26	for	for	ADP
bam-1791	12	27	its	its	PRON
bam-1791	12	28	aberrant	aberrant	NOUN
bam-1791	12	29	silencing	silence	VERB
bam-1791	12	30	in	in	ADP
bam-1791	12	31	some	some	DET
bam-1791	12	32	pathologies	pathology	NOUN
bam-1791	12	33	2	2	NUM
bam-1791	12	34	.	.	PUNCT
bam-1791	12	35	regulation	regulation	NOUN
bam-1791	12	36	of	of	ADP
bam-1791	12	37	alternative	alternative	ADJ
bam-1791	12	38	splicing	splicing	NOUN
bam-1791	12	39	during	during	ADP
bam-1791	12	40	myogenic	myogenic	ADJ
bam-1791	12	41	differentiation	differentiation	NOUN
bam-1791	12	42	maria	maria	PROPN
bam-1791	12	43	paola	paola	PROPN
bam-1791	12	44	paronetto1,2	paronetto1,2	PROPN
bam-1791	12	45	,	,	PUNCT
bam-1791	12	46	claudio	claudio	PROPN
bam-1791	12	47	sette2,3	sette2,3	PROPN
bam-1791	12	48	,	,	PUNCT
bam-1791	12	49	and	and	CCONJ
bam-1791	12	50	daniela	daniela	PROPN
bam-1791	12	51	caporossi1	caporossi1	PROPN
bam-1791	12	52	1	1	NUM
bam-1791	12	53	university	university	PROPN
bam-1791	12	54	of	of	ADP
bam-1791	12	55	rome	rome	PROPN
bam-1791	12	56	“	"	PUNCT
bam-1791	12	57	foro	foro	PROPN
bam-1791	12	58	italico	italico	PROPN
bam-1791	12	59	”	"	PUNCT
bam-1791	12	60	,	,	PUNCT
bam-1791	12	61	piazza	piazza	VERB
bam-1791	12	62	lauro	lauro	PROPN
bam-1791	12	63	de	de	ADP
bam-1791	12	64	bosis	bosis	PROPN
bam-1791	12	65	15	15	NUM
bam-1791	12	66	,	,	PUNCT
bam-1791	12	67	00135	00135	NUM
bam-1791	12	68	,	,	PUNCT
bam-1791	12	69	rome	rome	PROPN
bam-1791	12	70	,	,	PUNCT
bam-1791	12	71	italy	italy	PROPN
bam-1791	12	72	2	2	NUM
bam-1791	12	73	cerc	cerc	NOUN
bam-1791	12	74	fondazione	fondazione	NOUN
bam-1791	12	75	santa	santa	PROPN
bam-1791	12	76	lucia	lucia	PROPN
bam-1791	12	77	,	,	PUNCT
bam-1791	12	78	via	via	ADP
bam-1791	12	79	del	del	PROPN
bam-1791	12	80	fosso	fosso	PROPN
bam-1791	12	81	di	di	PROPN
bam-1791	12	82	fiorano	fiorano	PROPN
bam-1791	12	83	64	64	NUM
bam-1791	12	84	,	,	PUNCT
bam-1791	12	85	00143	00143	NUM
bam-1791	12	86	,	,	PUNCT
bam-1791	12	87	rome	rome	PROPN
bam-1791	12	88	,	,	PUNCT
bam-1791	12	89	italy	italy	PROPN
bam-1791	12	90	3	3	NUM
bam-1791	12	91	university	university	PROPN
bam-1791	12	92	of	of	ADP
bam-1791	12	93	rome	rome	PROPN
bam-1791	12	94	“	"	PUNCT
bam-1791	12	95	tor	tor	NOUN
bam-1791	12	96	vergata	vergata	NOUN
bam-1791	12	97	”	"	PUNCT
bam-1791	12	98	,	,	PUNCT
bam-1791	12	99	via	via	ADP
bam-1791	12	100	montpellier	montpellier	NOUN
bam-1791	12	101	1	1	NUM
bam-1791	12	102	,	,	PUNCT
bam-1791	12	103	00133	00133	NUM
bam-1791	12	104	,	,	PUNCT
bam-1791	12	105	rome	rome	PROPN
bam-1791	12	106	,	,	PUNCT
bam-1791	12	107	italy	italy	PROPN
bam-1791	12	108	post	post	NOUN
bam-1791	12	109	-	-	ADJ
bam-1791	12	110	transcriptional	transcriptional	ADJ
bam-1791	12	111	and	and	CCONJ
bam-1791	12	112	co	co	ADJ
bam-1791	12	113	-	-	ADJ
bam-1791	12	114	transcriptional	transcriptional	ADJ
bam-1791	12	115	regulation	regulation	NOUN
bam-1791	12	116	of	of	ADP
bam-1791	12	117	rna	rna	NOUN
bam-1791	12	118	processing	processing	NOUN
bam-1791	12	119	play	play	VERB
bam-1791	12	120	a	a	DET
bam-1791	12	121	crucial	crucial	ADJ
bam-1791	12	122	role	role	NOUN
bam-1791	12	123	in	in	ADP
bam-1791	12	124	generating	generate	VERB
bam-1791	12	125	protein	protein	NOUN
bam-1791	12	126	diversity	diversity	NOUN
bam-1791	12	127	,	,	PUNCT
bam-1791	12	128	thus	thus	ADV
bam-1791	12	129	modulating	modulate	VERB
bam-1791	12	130	many	many	ADJ
bam-1791	12	131	cellular	cellular	ADJ
bam-1791	12	132	processes	process	NOUN
bam-1791	12	133	such	such	ADJ
bam-1791	12	134	as	as	ADP
bam-1791	12	135	cellular	cellular	ADJ
bam-1791	12	136	differentiation	differentiation	NOUN
bam-1791	12	137	,	,	PUNCT
bam-1791	12	138	reprogramming	reprogramme	VERB
bam-1791	12	139	,	,	PUNCT
bam-1791	12	140	and	and	CCONJ
bam-1791	12	141	responses	response	NOUN
bam-1791	12	142	to	to	ADP
bam-1791	12	143	external	external	ADJ
bam-1791	12	144	stimuli	stimulus	NOUN
bam-1791	12	145	.	.	PUNCT
bam-1791	13	1	rna	rna	NOUN
bam-1791	13	2	binding	bind	VERB
bam-1791	13	3	proteins	protein	NOUN
bam-1791	13	4	participate	participate	VERB
bam-1791	13	5	to	to	ADP
bam-1791	13	6	this	this	DET
bam-1791	13	7	fine	fine	ADJ
bam-1791	13	8	regulation	regulation	NOUN
bam-1791	13	9	,	,	PUNCT
bam-1791	13	10	by	by	ADP
bam-1791	13	11	binding	bind	VERB
bam-1791	13	12	to	to	ADP
bam-1791	13	13	cis	cis	NOUN
bam-1791	13	14	-	-	PUNCT
bam-1791	13	15	regulatory	regulatory	ADJ
bam-1791	13	16	elements	element	NOUN
bam-1791	13	17	(	(	PUNCT
bam-1791	13	18	enhancers	enhancer	NOUN
bam-1791	13	19	and	and	CCONJ
bam-1791	13	20	silencers	silencer	NOUN
bam-1791	13	21	)	)	PUNCT
bam-1791	13	22	,	,	PUNCT
bam-1791	13	23	helping	help	VERB
bam-1791	13	24	the	the	DET
bam-1791	13	25	recruitment	recruitment	NOUN
bam-1791	13	26	of	of	ADP
bam-1791	13	27	the	the	DET
bam-1791	13	28	spliceosome	spliceosome	NOUN
bam-1791	13	29	and	and	CCONJ
bam-1791	13	30	allowing	allow	VERB
bam-1791	13	31	alternative	alternative	ADJ
bam-1791	13	32	splicing	splicing	NOUN
bam-1791	13	33	(	(	PUNCT
bam-1791	13	34	as	as	ADP
bam-1791	13	35	)	)	PUNCT
bam-1791	13	36	of	of	ADP
bam-1791	13	37	a	a	DET
bam-1791	13	38	multitude	multitude	NOUN
bam-1791	13	39	of	of	ADP
bam-1791	13	40	exons	exon	NOUN
bam-1791	13	41	.	.	PUNCT
bam-1791	14	1	genome	genome	NOUN
bam-1791	14	2	-	-	PUNCT
bam-1791	14	3	wide	wide	ADJ
bam-1791	14	4	analyses	analysis	NOUN
bam-1791	14	5	have	have	AUX
bam-1791	14	6	recently	recently	ADV
bam-1791	14	7	highlighted	highlight	VERB
bam-1791	14	8	an	an	DET
bam-1791	14	9	extensive	extensive	ADJ
bam-1791	14	10	modulation	modulation	NOUN
bam-1791	14	11	of	of	ADP
bam-1791	14	12	as	as	ADP
bam-1791	14	13	events	event	NOUN
bam-1791	14	14	during	during	ADP
bam-1791	14	15	myogenic	myogenic	ADJ
bam-1791	14	16	differentiation	differentiation	NOUN
bam-1791	14	17	of	of	ADP
bam-1791	14	18	c2c12	c2c12	PROPN
bam-1791	14	19	cells	cell	NOUN
bam-1791	14	20	,	,	PUNCT
bam-1791	14	21	suggesting	suggest	VERB
bam-1791	14	22	a	a	DET
bam-1791	14	23	major	major	ADJ
bam-1791	14	24	role	role	NOUN
bam-1791	14	25	for	for	ADP
bam-1791	14	26	as	as	ADP
bam-1791	14	27	in	in	ADP
bam-1791	14	28	the	the	DET
bam-1791	14	29	acquisition	acquisition	NOUN
bam-1791	14	30	of	of	ADP
bam-1791	14	31	the	the	DET
bam-1791	14	32	muscle	muscle	NOUN
bam-1791	14	33	protein	protein	NOUN
bam-1791	14	34	repertoire	repertoire	NOUN
bam-1791	14	35	.	.	PUNCT
bam-1791	15	1	by	by	ADP
bam-1791	15	2	using	use	VERB
bam-1791	15	3	c2c12	c2c12	PROPN
bam-1791	15	4	as	as	ADP
bam-1791	15	5	model	model	NOUN
bam-1791	15	6	system	system	NOUN
bam-1791	15	7	,	,	PUNCT
bam-1791	15	8	we	we	PRON
bam-1791	15	9	found	find	VERB
bam-1791	15	10	that	that	SCONJ
bam-1791	15	11	several	several	ADJ
bam-1791	15	12	splicing	splicing	NOUN
bam-1791	15	13	regulators	regulator	NOUN
bam-1791	15	14	undergo	undergo	VERB
bam-1791	15	15	dynamic	dynamic	ADJ
bam-1791	15	16	changes	change	NOUN
bam-1791	15	17	in	in	ADP
bam-1791	15	18	nuclear	nuclear	ADJ
bam-1791	15	19	abundance	abundance	NOUN
bam-1791	15	20	during	during	ADP
bam-1791	15	21	myogenic	myogenic	ADJ
bam-1791	15	22	differentiation	differentiation	NOUN
bam-1791	15	23	.	.	PUNCT
bam-1791	16	1	for	for	ADP
bam-1791	16	2	instance	instance	NOUN
bam-1791	16	3	,	,	PUNCT
bam-1791	16	4	the	the	DET
bam-1791	16	5	polypirimidine	polypirimidine	NOUN
bam-1791	16	6	tract	tract	NOUN
bam-1791	16	7	binding	bind	VERB
bam-1791	16	8	protein	protein	NOUN
bam-1791	16	9	(	(	PUNCT
bam-1791	16	10	ptb	ptb	PROPN
bam-1791	16	11	)	)	PUNCT
bam-1791	16	12	is	be	AUX
bam-1791	16	13	downregulated	downregulate	VERB
bam-1791	16	14	while	while	SCONJ
bam-1791	16	15	nptb	nptb	NOUN
bam-1791	16	16	is	be	AUX
bam-1791	16	17	upregulated	upregulate	VERB
bam-1791	16	18	.	.	PUNCT
bam-1791	17	1	moreover	moreover	ADV
bam-1791	17	2	,	,	PUNCT
bam-1791	17	3	we	we	PRON
bam-1791	17	4	observed	observe	VERB
bam-1791	17	5	an	an	DET
bam-1791	17	6	increase	increase	NOUN
bam-1791	17	7	of	of	ADP
bam-1791	17	8	safb	safb	NOUN
bam-1791	17	9	,	,	PUNCT
bam-1791	17	10	ews	ews	NOUN
bam-1791	17	11	and	and	CCONJ
bam-1791	17	12	sam68	sam68	NOUN
bam-1791	17	13	at	at	ADP
bam-1791	17	14	the	the	DET
bam-1791	17	15	onset	onset	NOUN
bam-1791	17	16	of	of	ADP
bam-1791	17	17	myogenic	myogenic	ADJ
bam-1791	17	18	differentiation	differentiation	NOUN
bam-1791	17	19	.	.	PUNCT
bam-1791	18	1	strikingly	strikingly	ADV
bam-1791	18	2	,	,	PUNCT
bam-1791	18	3	these	these	DET
bam-1791	18	4	rna	rna	NOUN
bam-1791	18	5	binding	bind	VERB
bam-1791	18	6	proteins	protein	NOUN
bam-1791	18	7	are	be	AUX
bam-1791	18	8	reported	report	VERB
bam-1791	18	9	to	to	PART
bam-1791	18	10	interact	interact	VERB
bam-1791	18	11	with	with	ADP
bam-1791	18	12	transcription	transcription	NOUN
bam-1791	18	13	factors	factor	NOUN
bam-1791	18	14	and	and	CCONJ
bam-1791	18	15	to	to	PART
bam-1791	18	16	play	play	VERB
bam-1791	18	17	a	a	DET
bam-1791	18	18	role	role	NOUN
bam-1791	18	19	in	in	ADP
bam-1791	18	20	co	co	NOUN
bam-1791	18	21	-	-	NOUN
bam-1791	18	22	transcriptional	transcriptional	ADJ
bam-1791	18	23	as	as	ADP
bam-1791	18	24	.	.	PUNCT
bam-1791	19	1	thus	thus	ADV
bam-1791	19	2	,	,	PUNCT
bam-1791	19	3	we	we	PRON
bam-1791	19	4	are	be	AUX
bam-1791	19	5	currently	currently	ADV
bam-1791	19	6	testing	test	VERB
bam-1791	19	7	whether	whether	SCONJ
bam-1791	19	8	these	these	DET
bam-1791	19	9	splicing	splicing	NOUN
bam-1791	19	10	factors	factor	NOUN
bam-1791	19	11	interact	interact	VERB
bam-1791	19	12	with	with	ADP
bam-1791	19	13	myogenic	myogenic	ADJ
bam-1791	19	14	transcription	transcription	NOUN
bam-1791	19	15	factors	factor	NOUN
bam-1791	19	16	in	in	ADP
bam-1791	19	17	a	a	DET
bam-1791	19	18	differentiation	differentiation	NOUN
bam-1791	19	19	-	-	PUNCT
bam-1791	19	20	dependent	dependent	ADJ
bam-1791	19	21	manner	manner	NOUN
bam-1791	19	22	.	.	PUNCT
bam-1791	20	1	the	the	DET
bam-1791	20	2	functional	functional	ADJ
bam-1791	20	3	coupling	coupling	NOUN
bam-1791	20	4	between	between	ADP
bam-1791	20	5	transcription	transcription	NOUN
bam-1791	20	6	and	and	CCONJ
bam-1791	20	7	alternative	alternative	ADJ
bam-1791	20	8	splicing	splicing	NOUN
bam-1791	20	9	is	be	AUX
bam-1791	20	10	being	be	AUX
bam-1791	20	11	investigated	investigate	VERB
bam-1791	20	12	within	within	ADP
bam-1791	20	13	key	key	ADJ
bam-1791	20	14	regulated	regulated	ADJ
bam-1791	20	15	genes	gene	NOUN
bam-1791	20	16	,	,	PUNCT
bam-1791	20	17	such	such	ADJ
bam-1791	20	18	as	as	ADP
bam-1791	20	19	the	the	DET
bam-1791	20	20	epsilon	epsilon	PROPN
bam-1791	20	21	sarcoglycan	sarcoglycan	PROPN
bam-1791	20	22	(	(	PUNCT
bam-1791	20	23	sgce	sgce	PROPN
bam-1791	20	24	)	)	PUNCT
bam-1791	20	25	,	,	PUNCT
bam-1791	20	26	which	which	PRON
bam-1791	20	27	encodes	encode	VERB
bam-1791	20	28	a	a	DET
bam-1791	20	29	transmembrane	transmembrane	ADJ
bam-1791	20	30	protein	protein	NOUN
bam-1791	20	31	component	component	NOUN
bam-1791	20	32	of	of	ADP
bam-1791	20	33	the	the	DET
bam-1791	20	34	dystrophin	dystrophin	NOUN
bam-1791	20	35	-	-	PUNCT
bam-1791	20	36	glycoprotein	glycoprotein	NOUN
bam-1791	20	37	complex	complex	NOUN
bam-1791	20	38	,	,	PUNCT
bam-1791	20	39	linking	link	VERB
bam-1791	20	40	the	the	DET
bam-1791	20	41	actin	actin	NOUN
bam-1791	20	42	cytoskeleton	cytoskeleton	PROPN
bam-1791	20	43	to	to	ADP
bam-1791	20	44	the	the	DET
bam-1791	20	45	extracellular	extracellular	ADJ
bam-1791	20	46	matrix	matrix	NOUN
bam-1791	20	47	.	.	PUNCT
bam-1791	21	1	our	our	PRON
bam-1791	21	2	studies	study	NOUN
bam-1791	21	3	aim	aim	VERB
bam-1791	21	4	at	at	ADP
bam-1791	21	5	providing	provide	VERB
bam-1791	21	6	a	a	DET
bam-1791	21	7	chart	chart	NOUN
bam-1791	21	8	of	of	ADP
bam-1791	21	9	the	the	DET
bam-1791	21	10	splicing	splicing	NOUN
bam-1791	21	11	factors	factor	NOUN
bam-1791	21	12	and	and	CCONJ
bam-1791	21	13	the	the	DET
bam-1791	21	14	splicing	splicing	NOUN
bam-1791	21	15	events	event	NOUN
bam-1791	21	16	regulated	regulate	VERB
bam-1791	21	17	during	during	ADP
bam-1791	21	18	myogenesis	myogenesis	NOUN
bam-1791	21	19	and	and	CCONJ
bam-1791	21	20	at	at	ADP
bam-1791	21	21	elucidating	elucidate	VERB
bam-1791	21	22	their	their	PRON
bam-1791	21	23	interplay	interplay	NOUN
bam-1791	21	24	with	with	ADP
bam-1791	21	25	master	master	NOUN
bam-1791	21	26	regulators	regulator	NOUN
bam-1791	21	27	of	of	ADP
bam-1791	21	28	muscle	muscle	NOUN
bam-1791	21	29	differentiation	differentiation	NOUN
bam-1791	21	30	.	.	PUNCT
bam-1791	22	1	ix	ix	PROPN
bam-1791	22	2	iim	iim	PROPN
bam-1791	22	3	meeting	meeting	NOUN
bam-1791	22	4	,	,	PUNCT
bam-1791	22	5	acaya	acaya	NOUN
bam-1791	22	6	(	(	PUNCT
bam-1791	22	7	lecce	lecce	PROPN
bam-1791	22	8	)	)	PUNCT
bam-1791	22	9	,	,	PUNCT
bam-1791	22	10	october	october	PROPN
bam-1791	22	11	12	12	NUM
bam-1791	22	12	-	-	SYM
bam-1791	22	13	14	14	NUM
bam-1791	22	14	,	,	PUNCT
bam-1791	22	15	2012	2012	NUM
bam-1791	22	16	european	european	PROPN
bam-1791	22	17	journal	journal	PROPN
bam-1791	22	18	translational	translational	ADJ
bam-1791	22	19	myology	myology	NOUN
bam-1791	22	20	basic	basic	ADJ
bam-1791	22	21	applied	apply	VERB
bam-1791	22	22	myology	myology	NOUN
bam-1791	22	23	2012	2012	NUM
bam-1791	22	24	;	;	PUNCT
bam-1791	22	25	22(1&2	22(1&2	NUM
bam-1791	22	26	):	):	PUNCT
bam-1791	22	27	xxx	xxx	NOUN
bam-1791	22	28	-	-	PUNCT
bam-1791	22	29	xxx	xxx	NOUN
bam-1791	22	30	21	21	NUM
bam-1791	22	31	3	3	NUM
bam-1791	22	32	.	.	PUNCT
bam-1791	23	1	the	the	DET
bam-1791	23	2	peculiar	peculiar	ADJ
bam-1791	23	3	skeletal	skeletal	ADJ
bam-1791	23	4	muscle	muscle	NOUN
bam-1791	23	5	apoptotic	apoptotic	ADJ
bam-1791	23	6	behavior	behavior	NOUN
bam-1791	23	7	s.	s.	PROPN
bam-1791	23	8	salucci1	salucci1	PROPN
bam-1791	23	9	,	,	PUNCT
bam-1791	23	10	v.	v.	ADP
bam-1791	23	11	baldassarri1	baldassarri1	PROPN
bam-1791	23	12	,	,	PUNCT
bam-1791	23	13	b.	b.	PROPN
bam-1791	23	14	canonico1	canonico1	PROPN
bam-1791	23	15	,	,	PUNCT
bam-1791	23	16	s.	s.	PROPN
bam-1791	23	17	burattini1	burattini1	PROPN
bam-1791	23	18	,	,	PUNCT
bam-1791	23	19	m.	m.	NOUN
bam-1791	23	20	battistelli1	battistelli1	PROPN
bam-1791	23	21	,	,	PUNCT
bam-1791	23	22	s.	s.	PROPN
bam-1791	23	23	papa1	papa1	PROPN
bam-1791	23	24	,	,	PUNCT
bam-1791	23	25	e.	e.	PROPN
bam-1791	23	26	falcieri1,3	falcieri1,3	PROPN
bam-1791	23	27	1disteva	1disteva	NUM
bam-1791	23	28	,	,	PUNCT
bam-1791	23	29	university	university	NOUN
bam-1791	23	30	of	of	ADP
bam-1791	23	31	urbino	urbino	PROPN
bam-1791	23	32	“	"	PUNCT
bam-1791	23	33	carlo	carlo	PROPN
bam-1791	23	34	bo	bo	PROPN
bam-1791	23	35	”	"	PUNCT
bam-1791	23	36	,	,	PUNCT
bam-1791	23	37	urbino	urbino	NOUN
bam-1791	23	38	;	;	PUNCT
bam-1791	23	39	2	2	NUM
bam-1791	23	40	igm	igm	PROPN
bam-1791	23	41	-	-	PUNCT
bam-1791	23	42	cnr	cnr	PROPN
bam-1791	23	43	,	,	PUNCT
bam-1791	23	44	istituti	istituti	VERB
bam-1791	23	45	ortopedici	ortopedici	PROPN
bam-1791	23	46	rizzoli	rizzoli	PROPN
bam-1791	23	47	,	,	PUNCT
bam-1791	23	48	bologna	bologna	PROPN
bam-1791	23	49	;	;	PUNCT
bam-1791	23	50	italy	italy	PROPN
bam-1791	23	51	.	.	PUNCT
bam-1791	24	1	apoptosis	apoptosis	NOUN
bam-1791	24	2	plays	play	VERB
bam-1791	24	3	an	an	DET
bam-1791	24	4	active	active	ADJ
bam-1791	24	5	role	role	NOUN
bam-1791	24	6	in	in	ADP
bam-1791	24	7	maintaining	maintain	VERB
bam-1791	24	8	skeletal	skeletal	ADJ
bam-1791	24	9	muscle	muscle	NOUN
bam-1791	24	10	homeostasis	homeostasis	NOUN
bam-1791	24	11	(	(	PUNCT
bam-1791	24	12	ferreira	ferreira	PROPN
bam-1791	24	13	et	et	PROPN
bam-1791	24	14	al	al	PROPN
bam-1791	24	15	.	.	PROPN
bam-1791	24	16	physiol	physiol	PROPN
bam-1791	24	17	res	res	PROPN
bam-1791	24	18	2008	2008	NUM
bam-1791	24	19	,	,	PUNCT
bam-1791	24	20	57	57	NUM
bam-1791	24	21	:	:	SYM
bam-1791	24	22	601	601	NUM
bam-1791	24	23	–	–	PUNCT
bam-1791	24	24	611	611	NUM
bam-1791	24	25	)	)	PUNCT
bam-1791	24	26	.	.	PUNCT
bam-1791	25	1	its	its	PRON
bam-1791	25	2	deregulation	deregulation	NOUN
bam-1791	25	3	is	be	AUX
bam-1791	25	4	involved	involve	VERB
bam-1791	25	5	in	in	ADP
bam-1791	25	6	several	several	ADJ
bam-1791	25	7	skeletal	skeletal	ADJ
bam-1791	25	8	muscle	muscle	NOUN
bam-1791	25	9	disorders	disorder	NOUN
bam-1791	25	10	such	such	ADJ
bam-1791	25	11	as	as	ADP
bam-1791	25	12	myopathies	myopathy	NOUN
bam-1791	25	13	,	,	PUNCT
bam-1791	25	14	disuse	disuse	NOUN
bam-1791	25	15	and	and	CCONJ
bam-1791	25	16	sarcopenia	sarcopenia	NOUN
bam-1791	25	17	(	(	PUNCT
bam-1791	25	18	dupont	dupont	NOUN
bam-1791	25	19	-	-	PUNCT
bam-1791	25	20	versteegden	versteegden	NOUN
bam-1791	25	21	,	,	PUNCT
bam-1791	25	22	world	world	NOUN
bam-1791	25	23	j	j	PROPN
bam-1791	25	24	gastroenterol	gastroenterol	PROPN
bam-1791	25	25	2006	2006	NUM
bam-1791	25	26	,	,	PUNCT
bam-1791	25	27	12:7463–7466	12:7463–7466	NUM
bam-1791	25	28	)	)	PUNCT
bam-1791	25	29	.	.	PUNCT
bam-1791	26	1	the	the	DET
bam-1791	26	2	aim	aim	NOUN
bam-1791	26	3	of	of	ADP
bam-1791	26	4	this	this	DET
bam-1791	26	5	work	work	NOUN
bam-1791	26	6	is	be	AUX
bam-1791	26	7	to	to	PART
bam-1791	26	8	further	far	ADV
bam-1791	26	9	highlight	highlight	VERB
bam-1791	26	10	in	in	ADP
bam-1791	26	11	vitro	vitro	X
bam-1791	26	12	the	the	DET
bam-1791	26	13	apoptotic	apoptotic	ADJ
bam-1791	26	14	behavior	behavior	NOUN
bam-1791	26	15	of	of	ADP
bam-1791	26	16	c2c12	c2c12	PROPN
bam-1791	26	17	myoblasts	myoblast	NOUN
bam-1791	26	18	and	and	CCONJ
bam-1791	26	19	myotubes	myotube	NOUN
bam-1791	26	20	.	.	PUNCT
bam-1791	27	1	cell	cell	NOUN
bam-1791	27	2	death	death	NOUN
bam-1791	27	3	has	have	AUX
bam-1791	27	4	been	be	AUX
bam-1791	27	5	induced	induce	VERB
bam-1791	27	6	by	by	ADP
bam-1791	27	7	etoposide	etoposide	NOUN
bam-1791	27	8	,	,	PUNCT
bam-1791	27	9	staurosporine	staurosporine	NOUN
bam-1791	27	10	and	and	CCONJ
bam-1791	27	11	hydrogen	hydrogen	NOUN
bam-1791	27	12	peroxide	peroxide	NOUN
bam-1791	27	13	and	and	CCONJ
bam-1791	27	14	investigated	investigate	VERB
bam-1791	27	15	by	by	ADP
bam-1791	27	16	means	mean	NOUN
bam-1791	27	17	of	of	ADP
bam-1791	27	18	morphological	morphological	ADJ
bam-1791	27	19	and	and	CCONJ
bam-1791	27	20	cytofluorimetric	cytofluorimetric	NOUN
bam-1791	27	21	analyses	analysis	NOUN
bam-1791	27	22	.	.	PUNCT
bam-1791	28	1	myotubes	myotube	NOUN
bam-1791	28	2	appeared	appear	VERB
bam-1791	28	3	more	more	ADV
bam-1791	28	4	resistant	resistant	ADJ
bam-1791	28	5	to	to	ADP
bam-1791	28	6	apoptotic	apoptotic	ADJ
bam-1791	28	7	induction	induction	NOUN
bam-1791	28	8	than	than	ADP
bam-1791	28	9	myoblasts	myoblast	NOUN
bam-1791	28	10	.	.	PUNCT
bam-1791	29	1	in	in	ADP
bam-1791	29	2	myoblasts	myoblast	NOUN
bam-1791	29	3	treated	treat	VERB
bam-1791	29	4	with	with	ADP
bam-1791	29	5	etoposide	etoposide	NOUN
bam-1791	29	6	,	,	PUNCT
bam-1791	29	7	nuclei	nucleus	NOUN
bam-1791	29	8	with	with	ADP
bam-1791	29	9	chromatin	chromatin	NOUN
bam-1791	29	10	condensation	condensation	NOUN
bam-1791	29	11	were	be	AUX
bam-1791	29	12	observed	observe	VERB
bam-1791	29	13	,	,	PUNCT
bam-1791	29	14	in	in	ADP
bam-1791	29	15	the	the	DET
bam-1791	29	16	presence	presence	NOUN
bam-1791	29	17	of	of	ADP
bam-1791	29	18	a	a	DET
bam-1791	29	19	diffuse	diffuse	ADJ
bam-1791	29	20	dna	dna	PROPN
bam-1791	29	21	fragmentation	fragmentation	NOUN
bam-1791	29	22	,	,	PUNCT
bam-1791	29	23	shown	show	VERB
bam-1791	29	24	by	by	ADP
bam-1791	29	25	tunel	tunel	ADJ
bam-1791	29	26	reaction	reaction	NOUN
bam-1791	29	27	.	.	PUNCT
bam-1791	30	1	the	the	DET
bam-1791	30	2	latter	latter	ADJ
bam-1791	30	3	appeared	appear	VERB
bam-1791	30	4	also	also	ADV
bam-1791	30	5	in	in	ADP
bam-1791	30	6	myotubes	myotube	NOUN
bam-1791	30	7	,	,	PUNCT
bam-1791	30	8	where	where	SCONJ
bam-1791	30	9	apoptotic	apoptotic	ADJ
bam-1791	30	10	and	and	CCONJ
bam-1791	30	11	normal	normal	ADJ
bam-1791	30	12	nuclei	nucleus	NOUN
bam-1791	30	13	inside	inside	ADP
bam-1791	30	14	the	the	DET
bam-1791	30	15	same	same	ADJ
bam-1791	30	16	syncytium	syncytium	NOUN
bam-1791	30	17	were	be	AUX
bam-1791	30	18	revealed	reveal	VERB
bam-1791	30	19	(	(	PUNCT
bam-1791	30	20	d’emilio	d’emilio	X
bam-1791	30	21	et	et	PROPN
bam-1791	30	22	al	al	PROPN
bam-1791	30	23	.	.	PROPN
bam-1791	31	1	histol	histol	PROPN
bam-1791	31	2	histopathol	histopathol	NOUN
bam-1791	31	3	2010	2010	NUM
bam-1791	31	4	,	,	PUNCT
bam-1791	31	5	25	25	NUM
bam-1791	31	6	:	:	SYM
bam-1791	31	7	21	21	NUM
bam-1791	31	8	-	-	SYM
bam-1791	31	9	32	32	NUM
bam-1791	31	10	)	)	PUNCT
bam-1791	31	11	.	.	PUNCT
bam-1791	32	1	staurosporine	staurosporine	PROPN
bam-1791	32	2	treated	treat	VERB
bam-1791	32	3	-	-	PUNCT
bam-1791	32	4	myobalsts	myobalst	NOUN
bam-1791	32	5	evidenced	evidence	VERB
bam-1791	32	6	late	late	ADJ
bam-1791	32	7	apoptotic	apoptotic	ADJ
bam-1791	32	8	features	feature	NOUN
bam-1791	32	9	and	and	CCONJ
bam-1791	32	10	a	a	DET
bam-1791	32	11	high	high	ADJ
bam-1791	32	12	number	number	NOUN
bam-1791	32	13	of	of	ADP
bam-1791	32	14	tunel	tunel	ADJ
bam-1791	32	15	-	-	ADJ
bam-1791	32	16	positive	positive	ADJ
bam-1791	32	17	nuclei	nucleus	NOUN
bam-1791	32	18	.	.	PUNCT
bam-1791	33	1	secondary	secondary	ADJ
bam-1791	33	2	necrosis	necrosis	NOUN
bam-1791	33	3	appeared	appear	VERB
bam-1791	33	4	in	in	ADP
bam-1791	33	5	myotubes	myotube	NOUN
bam-1791	33	6	,	,	PUNCT
bam-1791	33	7	where	where	SCONJ
bam-1791	33	8	myonuclei	myonuclei	NOUN
bam-1791	33	9	with	with	ADP
bam-1791	33	10	cleaved	cleaved	ADJ
bam-1791	33	11	dna	dna	NOUN
bam-1791	33	12	coexisted	coexist	VERB
bam-1791	33	13	,	,	PUNCT
bam-1791	33	14	again	again	ADV
bam-1791	33	15	,	,	PUNCT
bam-1791	33	16	with	with	ADP
bam-1791	33	17	the	the	DET
bam-1791	33	18	normal	normal	ADJ
bam-1791	33	19	ones	one	NOUN
bam-1791	33	20	.	.	PUNCT
bam-1791	34	1	after	after	ADP
bam-1791	34	2	h2o2	h2o2	NOUN
bam-1791	34	3	exposure	exposure	NOUN
bam-1791	34	4	,	,	PUNCT
bam-1791	34	5	myotubes	myotube	NOUN
bam-1791	34	6	,	,	PUNCT
bam-1791	34	7	differently	differently	ADV
bam-1791	34	8	from	from	ADP
bam-1791	34	9	myoblasts	myoblast	NOUN
bam-1791	34	10	,	,	PUNCT
bam-1791	34	11	showed	show	VERB
bam-1791	34	12	a	a	DET
bam-1791	34	13	poor	poor	ADJ
bam-1791	34	14	sensitivity	sensitivity	NOUN
bam-1791	34	15	to	to	PART
bam-1791	34	16	cell	cell	VERB
bam-1791	34	17	death	death	NOUN
bam-1791	34	18	.	.	PUNCT
bam-1791	35	1	intriguingly	intriguingly	ADV
bam-1791	35	2	,	,	PUNCT
bam-1791	35	3	autophagic	autophagic	ADJ
bam-1791	35	4	granules	granule	NOUN
bam-1791	35	5	diffusely	diffusely	ADV
bam-1791	35	6	appeared	appear	VERB
bam-1791	35	7	in	in	ADP
bam-1791	35	8	myotubes	myotube	NOUN
bam-1791	35	9	after	after	ADP
bam-1791	35	10	each	each	DET
bam-1791	35	11	treatment	treatment	NOUN
bam-1791	35	12	.	.	PUNCT
bam-1791	36	1	moreover	moreover	ADV
bam-1791	36	2	,	,	PUNCT
bam-1791	36	3	mitochondria	mitochondria	PROPN
bam-1791	36	4	appeared	appear	VERB
bam-1791	36	5	better	well	ADV
bam-1791	36	6	preserved	preserve	VERB
bam-1791	36	7	than	than	ADP
bam-1791	36	8	in	in	ADP
bam-1791	36	9	myoblasts	myoblast	NOUN
bam-1791	36	10	.	.	PUNCT
bam-1791	37	1	taken	take	VERB
bam-1791	37	2	together	together	ADV
bam-1791	37	3	,	,	PUNCT
bam-1791	37	4	these	these	DET
bam-1791	37	5	findings	finding	NOUN
bam-1791	37	6	demonstrate	demonstrate	VERB
bam-1791	37	7	myotube	myotube	NOUN
bam-1791	37	8	resistance	resistance	NOUN
bam-1791	37	9	to	to	ADP
bam-1791	37	10	apoptotic	apoptotic	ADJ
bam-1791	37	11	stimuli	stimulus	NOUN
bam-1791	37	12	.	.	PUNCT
bam-1791	38	1	moreover	moreover	ADV
bam-1791	38	2	,	,	PUNCT
bam-1791	38	3	the	the	DET
bam-1791	38	4	presence	presence	NOUN
bam-1791	38	5	of	of	ADP
bam-1791	38	6	independent	independent	ADJ
bam-1791	38	7	nuclear	nuclear	ADJ
bam-1791	38	8	domains	domain	NOUN
bam-1791	38	9	could	could	AUX
bam-1791	38	10	explain	explain	VERB
bam-1791	38	11	a	a	DET
bam-1791	38	12	slower	slow	ADJ
bam-1791	38	13	death	death	NOUN
bam-1791	38	14	of	of	ADP
bam-1791	38	15	myotubes	myotube	NOUN
bam-1791	38	16	if	if	SCONJ
bam-1791	38	17	compared	compare	VERB
bam-1791	38	18	to	to	ADP
bam-1791	38	19	mononucleated	mononucleate	VERB
bam-1791	38	20	cells	cell	NOUN
bam-1791	38	21	.	.	PUNCT
bam-1791	39	1	in	in	ADP
bam-1791	39	2	addition	addition	NOUN
bam-1791	39	3	,	,	PUNCT
bam-1791	39	4	autophagy	autophagy	NOUN
bam-1791	39	5	could	could	AUX
bam-1791	39	6	preserve	preserve	VERB
bam-1791	39	7	muscle	muscle	NOUN
bam-1791	39	8	cell	cell	NOUN
bam-1791	39	9	integrity	integrity	NOUN
bam-1791	39	10	against	against	ADP
bam-1791	39	11	chemical	chemical	NOUN
bam-1791	39	12	stimuli	stimulus	NOUN
bam-1791	39	13	,	,	PUNCT
bam-1791	39	14	making	make	VERB
bam-1791	39	15	c2c12	c2c12	NOUN
bam-1791	39	16	cells	cell	NOUN
bam-1791	39	17	,	,	PUNCT
bam-1791	39	18	in	in	ADP
bam-1791	39	19	particular	particular	ADJ
bam-1791	39	20	myotubes	myotube	NOUN
bam-1791	39	21	,	,	PUNCT
bam-1791	39	22	more	more	ADV
bam-1791	39	23	resistant	resistant	ADJ
bam-1791	39	24	to	to	ADP
bam-1791	39	25	apoptosis	apoptosis	NOUN
bam-1791	39	26	induction	induction	NOUN
bam-1791	39	27	.	.	PUNCT
bam-1791	40	1	4	4	X
bam-1791	40	2	.	.	X
bam-1791	40	3	relaxin	relaxin	NOUN
bam-1791	40	4	affects	affect	VERB
bam-1791	40	5	spontaneous	spontaneous	ADJ
bam-1791	40	6	rhythmic	rhythmic	ADJ
bam-1791	40	7	contraction	contraction	NOUN
bam-1791	40	8	and	and	CCONJ
bam-1791	40	9	voltage	voltage	NOUN
bam-1791	40	10	membrane	membrane	NOUN
bam-1791	40	11	potential	potential	NOUN
bam-1791	40	12	on	on	ADP
bam-1791	40	13	the	the	DET
bam-1791	40	14	mouse	mouse	NOUN
bam-1791	40	15	colon	colon	NOUN
bam-1791	40	16	fabio	fabio	NOUN
bam-1791	40	17	francini	francini	PROPN
bam-1791	40	18	,	,	PUNCT
bam-1791	40	19	roberta	roberta	PROPN
bam-1791	40	20	squecco	squecco	PROPN
bam-1791	40	21	,	,	PUNCT
bam-1791	40	22	rachele	rachele	PROPN
bam-1791	40	23	garella	garella	PROPN
bam-1791	40	24	,	,	PUNCT
bam-1791	40	25	maria	maria	PROPN
bam-1791	40	26	caterina	caterina	PROPN
bam-1791	40	27	baccari	baccari	PROPN
bam-1791	40	28	department	department	PROPN
bam-1791	40	29	of	of	ADP
bam-1791	40	30	physiological	physiological	ADJ
bam-1791	40	31	sciences	science	NOUN
bam-1791	40	32	,	,	PUNCT
bam-1791	40	33	university	university	NOUN
bam-1791	40	34	of	of	ADP
bam-1791	40	35	florence	florence	NOUN
bam-1791	40	36	;	;	PUNCT
bam-1791	40	37	iim	iim	PROPN
bam-1791	40	38	,	,	PUNCT
bam-1791	40	39	italy	italy	PROPN
bam-1791	40	40	.	.	PUNCT
bam-1791	41	1	relaxin	relaxin	PROPN
bam-1791	41	2	has	have	AUX
bam-1791	41	3	been	be	AUX
bam-1791	41	4	reported	report	VERB
bam-1791	41	5	to	to	PART
bam-1791	41	6	influence	influence	VERB
bam-1791	41	7	gastrointestinal	gastrointestinal	ADJ
bam-1791	41	8	motility	motility	NOUN
bam-1791	41	9	in	in	ADP
bam-1791	41	10	mice	mouse	NOUN
bam-1791	41	11	acting	act	VERB
bam-1791	41	12	at	at	ADP
bam-1791	41	13	either	either	CCONJ
bam-1791	41	14	the	the	DET
bam-1791	41	15	neurotransmission	neurotransmission	NOUN
bam-1791	41	16	or	or	CCONJ
bam-1791	41	17	the	the	DET
bam-1791	41	18	smooth	smooth	ADJ
bam-1791	41	19	muscle	muscle	NOUN
bam-1791	41	20	level	level	NOUN
bam-1791	41	21	,	,	PUNCT
bam-1791	41	22	depending	depend	VERB
bam-1791	41	23	on	on	ADP
bam-1791	41	24	the	the	DET
bam-1791	41	25	gut	gut	NOUN
bam-1791	41	26	segment	segment	NOUN
bam-1791	41	27	considered	consider	VERB
bam-1791	41	28	.	.	PUNCT
bam-1791	42	1	however	however	ADV
bam-1791	42	2	,	,	PUNCT
bam-1791	42	3	at	at	ADP
bam-1791	42	4	present	present	ADJ
bam-1791	42	5	,	,	PUNCT
bam-1791	42	6	nothing	nothing	PRON
bam-1791	42	7	is	be	AUX
bam-1791	42	8	known	know	VERB
bam-1791	42	9	about	about	ADP
bam-1791	42	10	the	the	DET
bam-1791	42	11	effects	effect	NOUN
bam-1791	42	12	of	of	ADP
bam-1791	42	13	relaxin	relaxin	NOUN
bam-1791	42	14	on	on	ADP
bam-1791	42	15	the	the	DET
bam-1791	42	16	electrophysiological	electrophysiological	ADJ
bam-1791	42	17	properties	property	NOUN
bam-1791	42	18	of	of	ADP
bam-1791	42	19	the	the	DET
bam-1791	42	20	gastrointestinal	gastrointestinal	ADJ
bam-1791	42	21	smooth	smooth	ADJ
bam-1791	42	22	muscle	muscle	NOUN
bam-1791	42	23	.	.	PUNCT
bam-1791	43	1	in	in	ADP
bam-1791	43	2	the	the	DET
bam-1791	43	3	present	present	ADJ
bam-1791	43	4	experiments	experiment	NOUN
bam-1791	43	5	the	the	DET
bam-1791	43	6	effects	effect	NOUN
bam-1791	43	7	of	of	ADP
bam-1791	43	8	relaxin	relaxin	NOUN
bam-1791	43	9	on	on	ADP
bam-1791	43	10	colonic	colonic	ADJ
bam-1791	43	11	motility	motility	NOUN
bam-1791	43	12	in	in	ADP
bam-1791	43	13	mice	mouse	NOUN
bam-1791	43	14	were	be	AUX
bam-1791	43	15	further	far	ADV
bam-1791	43	16	investigated	investigate	VERB
bam-1791	43	17	and	and	CCONJ
bam-1791	43	18	electrophysiological	electrophysiological	ADJ
bam-1791	43	19	records	record	NOUN
bam-1791	43	20	in	in	ADP
bam-1791	43	21	a	a	DET
bam-1791	43	22	single	single	ADJ
bam-1791	43	23	smooth	smooth	ADJ
bam-1791	43	24	muscle	muscle	NOUN
bam-1791	43	25	cell	cell	NOUN
bam-1791	43	26	were	be	AUX
bam-1791	43	27	also	also	ADV
bam-1791	43	28	performed	perform	VERB
bam-1791	43	29	.	.	PUNCT
bam-1791	44	1	for	for	ADP
bam-1791	44	2	this	this	DET
bam-1791	44	3	combined	combine	VERB
bam-1791	44	4	approach	approach	NOUN
bam-1791	44	5	,	,	PUNCT
bam-1791	44	6	preparations	preparation	NOUN
bam-1791	44	7	from	from	ADP
bam-1791	44	8	the	the	DET
bam-1791	44	9	proximal	proximal	ADJ
bam-1791	44	10	colon	colon	NOUN
bam-1791	44	11	were	be	AUX
bam-1791	44	12	mounted	mount	VERB
bam-1791	44	13	in	in	ADP
bam-1791	44	14	organ	organ	NOUN
bam-1791	44	15	baths	bath	NOUN
bam-1791	44	16	for	for	ADP
bam-1791	44	17	isometric	isometric	ADJ
bam-1791	44	18	recording	recording	NOUN
bam-1791	44	19	of	of	ADP
bam-1791	44	20	the	the	DET
bam-1791	44	21	mechanical	mechanical	ADJ
bam-1791	44	22	activity	activity	NOUN
bam-1791	44	23	,	,	PUNCT
bam-1791	44	24	whereas	whereas	SCONJ
bam-1791	44	25	membrane	membrane	NOUN
bam-1791	44	26	potential	potential	NOUN
bam-1791	44	27	was	be	AUX
bam-1791	44	28	recorded	record	VERB
bam-1791	44	29	in	in	ADP
bam-1791	44	30	current	current	ADJ
bam-1791	44	31	-	-	PUNCT
bam-1791	44	32	clamp	clamp	NOUN
bam-1791	44	33	conditions	condition	NOUN
bam-1791	44	34	by	by	ADP
bam-1791	44	35	single	single	ADJ
bam-1791	44	36	microelectrode	microelectrode	NOUN
bam-1791	44	37	inserted	insert	VERB
bam-1791	44	38	in	in	ADP
bam-1791	44	39	a	a	DET
bam-1791	44	40	smooth	smooth	ADJ
bam-1791	44	41	muscle	muscle	NOUN
bam-1791	44	42	cell	cell	NOUN
bam-1791	44	43	.	.	PUNCT
bam-1791	45	1	colonic	colonic	ADJ
bam-1791	45	2	preparations	preparation	NOUN
bam-1791	45	3	exhibited	exhibit	VERB
bam-1791	45	4	spontaneous	spontaneous	ADJ
bam-1791	45	5	contractile	contractile	NOUN
bam-1791	45	6	activity	activity	NOUN
bam-1791	45	7	consisting	consist	VERB
bam-1791	45	8	of	of	ADP
bam-1791	45	9	rhythmic	rhythmic	ADJ
bam-1791	45	10	changes	change	NOUN
bam-1791	45	11	in	in	ADP
bam-1791	45	12	isometric	isometric	ADJ
bam-1791	45	13	tension	tension	NOUN
bam-1791	45	14	.	.	PUNCT
bam-1791	46	1	relaxin	relaxin	NOUN
bam-1791	46	2	caused	cause	VERB
bam-1791	46	3	a	a	DET
bam-1791	46	4	decay	decay	NOUN
bam-1791	46	5	of	of	ADP
bam-1791	46	6	the	the	DET
bam-1791	46	7	basal	basal	ADJ
bam-1791	46	8	tension	tension	NOUN
bam-1791	46	9	,	,	PUNCT
bam-1791	46	10	that	that	PRON
bam-1791	46	11	persisted	persist	VERB
bam-1791	46	12	for	for	ADP
bam-1791	46	13	the	the	DET
bam-1791	46	14	whole	whole	ADJ
bam-1791	46	15	time	time	NOUN
bam-1791	46	16	of	of	ADP
bam-1791	46	17	exposure	exposure	NOUN
bam-1791	46	18	,	,	PUNCT
bam-1791	46	19	coupled	couple	VERB
bam-1791	46	20	by	by	ADP
bam-1791	46	21	a	a	DET
bam-1791	46	22	stable	stable	ADJ
bam-1791	46	23	and	and	CCONJ
bam-1791	46	24	long	long	ADV
bam-1791	46	25	-	-	PUNCT
bam-1791	46	26	lasting	last	VERB
bam-1791	46	27	increase	increase	NOUN
bam-1791	46	28	in	in	ADP
bam-1791	46	29	amplitude	amplitude	NOUN
bam-1791	46	30	of	of	ADP
bam-1791	46	31	the	the	DET
bam-1791	46	32	spontaneous	spontaneous	ADJ
bam-1791	46	33	contractions	contraction	NOUN
bam-1791	46	34	.	.	PUNCT
bam-1791	47	1	tetrodotoxin	tetrodotoxin	NOUN
bam-1791	47	2	,	,	PUNCT
bam-1791	47	3	only	only	ADV
bam-1791	47	4	abolished	abolish	VERB
bam-1791	47	5	the	the	DET
bam-1791	47	6	initial	initial	ADJ
bam-1791	47	7	phase	phase	NOUN
bam-1791	47	8	of	of	ADP
bam-1791	47	9	the	the	DET
bam-1791	47	10	basal	basal	ADJ
bam-1791	47	11	tension	tension	NOUN
bam-1791	47	12	decay	decay	NOUN
bam-1791	47	13	.	.	PUNCT
bam-1791	48	1	electrophysiological	electrophysiological	ADJ
bam-1791	48	2	records	record	NOUN
bam-1791	48	3	showed	show	VERB
bam-1791	48	4	rhythmic	rhythmic	ADJ
bam-1791	48	5	changes	change	NOUN
bam-1791	48	6	in	in	ADP
bam-1791	48	7	the	the	DET
bam-1791	48	8	resting	rest	VERB
bam-1791	48	9	membrane	membrane	NOUN
bam-1791	48	10	potential	potential	NOUN
bam-1791	48	11	.	.	PUNCT
bam-1791	49	1	relaxin	relaxin	NOUN
bam-1791	49	2	induced	induce	VERB
bam-1791	49	3	the	the	DET
bam-1791	49	4	following	follow	VERB
bam-1791	49	5	changes	change	NOUN
bam-1791	49	6	:	:	PUNCT
bam-1791	49	7	an	an	DET
bam-1791	49	8	early	early	ADJ
bam-1791	49	9	slow	slow	ADJ
bam-1791	49	10	hyperpolarisation	hyperpolarisation	NOUN
bam-1791	49	11	,	,	PUNCT
bam-1791	49	12	followed	follow	VERB
bam-1791	49	13	by	by	ADP
bam-1791	49	14	a	a	DET
bam-1791	49	15	slow	slow	ADJ
bam-1791	49	16	spontaneous	spontaneous	ADJ
bam-1791	49	17	membrane	membrane	NOUN
bam-1791	49	18	potential	potential	ADJ
bam-1791	49	19	recovery	recovery	NOUN
bam-1791	49	20	up	up	ADP
bam-1791	49	21	to	to	ADP
bam-1791	49	22	a	a	DET
bam-1791	49	23	slightly	slightly	ADJ
bam-1791	49	24	depolarisation	depolarisation	NOUN
bam-1791	49	25	and	and	CCONJ
bam-1791	49	26	,	,	PUNCT
bam-1791	49	27	finally	finally	ADV
bam-1791	49	28	,	,	PUNCT
bam-1791	49	29	a	a	DET
bam-1791	49	30	late	late	ADJ
bam-1791	49	31	increase	increase	NOUN
bam-1791	49	32	of	of	ADP
bam-1791	49	33	the	the	DET
bam-1791	49	34	rhythmic	rhythmic	ADJ
bam-1791	49	35	rate	rate	NOUN
bam-1791	49	36	of	of	ADP
bam-1791	49	37	potential	potential	ADJ
bam-1791	49	38	waves	wave	NOUN
bam-1791	49	39	were	be	AUX
bam-1791	49	40	observed	observe	VERB
bam-1791	49	41	with	with	ADP
bam-1791	49	42	sometimes	sometimes	ADV
bam-1791	49	43	some	some	DET
bam-1791	49	44	spikes	spike	NOUN
bam-1791	49	45	superimposed	superimpose	VERB
bam-1791	49	46	.	.	PUNCT
bam-1791	50	1	these	these	DET
bam-1791	50	2	electrophysiological	electrophysiological	ADJ
bam-1791	50	3	observations	observation	NOUN
bam-1791	50	4	are	be	AUX
bam-1791	50	5	in	in	ADP
bam-1791	50	6	agreement	agreement	NOUN
bam-1791	50	7	with	with	ADP
bam-1791	50	8	mechanical	mechanical	ADJ
bam-1791	50	9	ones	one	NOUN
bam-1791	50	10	.	.	PUNCT
bam-1791	51	1	the	the	DET
bam-1791	51	2	present	present	ADJ
bam-1791	51	3	results	result	NOUN
bam-1791	51	4	indicate	indicate	VERB
bam-1791	51	5	that	that	DET
bam-1791	51	6	relaxin	relaxin	NOUN
bam-1791	51	7	other	other	ADJ
bam-1791	51	8	than	than	ADP
bam-1791	51	9	acting	act	VERB
bam-1791	51	10	on	on	ADP
bam-1791	51	11	the	the	DET
bam-1791	51	12	cholinergic	cholinergic	ADJ
bam-1791	51	13	neurotransmission	neurotransmission	NOUN
bam-1791	51	14	,	,	PUNCT
bam-1791	51	15	directly	directly	ADV
bam-1791	51	16	influences	influence	VERB
bam-1791	51	17	colonic	colonic	ADJ
bam-1791	51	18	smooth	smooth	ADJ
bam-1791	51	19	muscle	muscle	NOUN
bam-1791	51	20	properties	property	NOUN
bam-1791	51	21	.	.	PUNCT
bam-1791	52	1	5	5	X
bam-1791	52	2	.	.	X
bam-1791	52	3	direct	direct	ADJ
bam-1791	52	4	lineage	lineage	NOUN
bam-1791	52	5	reprogramming	reprogramme	VERB
bam-1791	52	6	as	as	ADP
bam-1791	52	7	novel	novel	ADJ
bam-1791	52	8	strategy	strategy	NOUN
bam-1791	52	9	to	to	PART
bam-1791	52	10	generate	generate	VERB
bam-1791	52	11	cardiomyocytes	cardiomyocyte	NOUN
bam-1791	52	12	giacomo	giacomo	PROPN
bam-1791	52	13	palazzolo1	palazzolo1	PROPN
bam-1791	52	14	,	,	PUNCT
bam-1791	52	15	marco	marco	PROPN
bam-1791	52	16	cassano	cassano	PROPN
bam-1791	52	17	,	,	PUNCT
bam-1791	52	18	and	and	CCONJ
bam-1791	52	19	maurilio	maurilio	VERB
bam-1791	52	20	sampaolesi1,2	sampaolesi1,2	PROPN
bam-1791	52	21	1laboratory	1laboratory	NUM
bam-1791	52	22	of	of	ADP
bam-1791	52	23	translational	translational	ADJ
bam-1791	52	24	cardiomyology	cardiomyology	NOUN
bam-1791	52	25	,	,	PUNCT
bam-1791	52	26	scil	scil	PROPN
bam-1791	52	27	,	,	PUNCT
bam-1791	52	28	ku	ku	PROPN
bam-1791	52	29	leuven	leuven	PROPN
bam-1791	52	30	,	,	PUNCT
bam-1791	52	31	belgium	belgium	NOUN
bam-1791	52	32	;	;	PUNCT
bam-1791	52	33	2department	2department	NUM
bam-1791	52	34	of	of	ADP
bam-1791	52	35	public	public	ADJ
bam-1791	52	36	health	health	NOUN
bam-1791	52	37	,	,	PUNCT
bam-1791	52	38	neuroscience	neuroscience	NOUN
bam-1791	52	39	,	,	PUNCT
bam-1791	52	40	experimental	experimental	ADJ
bam-1791	52	41	and	and	CCONJ
bam-1791	52	42	forensic	forensic	ADJ
bam-1791	52	43	medicine	medicine	NOUN
bam-1791	52	44	,	,	PUNCT
bam-1791	52	45	pavia	pavia	PROPN
bam-1791	52	46	,	,	PUNCT
bam-1791	52	47	italy	italy	PROPN
bam-1791	52	48	the	the	DET
bam-1791	52	49	direct	direct	ADJ
bam-1791	52	50	lineage	lineage	NOUN
bam-1791	52	51	reprogramming	reprogramme	VERB
bam-1791	52	52	is	be	AUX
bam-1791	52	53	a	a	DET
bam-1791	52	54	promising	promising	ADJ
bam-1791	52	55	strategy	strategy	NOUN
bam-1791	52	56	in	in	ADP
bam-1791	52	57	regenerative	regenerative	ADJ
bam-1791	52	58	medicine	medicine	NOUN
bam-1791	52	59	.	.	PUNCT
bam-1791	53	1	using	use	VERB
bam-1791	53	2	a	a	DET
bam-1791	53	3	mix	mix	NOUN
bam-1791	53	4	of	of	ADP
bam-1791	53	5	exogenous	exogenous	ADJ
bam-1791	53	6	transcription	transcription	NOUN
bam-1791	53	7	factors	factor	NOUN
bam-1791	53	8	is	be	AUX
bam-1791	53	9	possible	possible	ADJ
bam-1791	53	10	to	to	PART
bam-1791	53	11	force	force	VERB
bam-1791	53	12	a	a	DET
bam-1791	53	13	direct	direct	ADJ
bam-1791	53	14	transdifferentiation	transdifferentiation	NOUN
bam-1791	53	15	to	to	ADP
bam-1791	53	16	specific	specific	ADJ
bam-1791	53	17	lineage	lineage	NOUN
bam-1791	53	18	without	without	ADP
bam-1791	53	19	production	production	NOUN
bam-1791	53	20	of	of	ADP
bam-1791	53	21	precursor	precursor	NOUN
bam-1791	53	22	cells	cell	NOUN
bam-1791	53	23	.	.	PUNCT
bam-1791	54	1	the	the	DET
bam-1791	54	2	aim	aim	NOUN
bam-1791	54	3	of	of	ADP
bam-1791	54	4	our	our	PRON
bam-1791	54	5	study	study	NOUN
bam-1791	54	6	is	be	AUX
bam-1791	54	7	to	to	PART
bam-1791	54	8	evaluate	evaluate	VERB
bam-1791	54	9	the	the	DET
bam-1791	54	10	feasibility	feasibility	NOUN
bam-1791	54	11	to	to	PART
bam-1791	54	12	transdifferentiate	transdifferentiate	VERB
bam-1791	54	13	canine	canine	NOUN
bam-1791	54	14	skin	skin	NOUN
bam-1791	54	15	fibroblasts	fibroblast	NOUN
bam-1791	54	16	into	into	ADP
bam-1791	54	17	cardiomyocytes	cardiomyocyte	NOUN
bam-1791	54	18	ix	ix	ADP
bam-1791	54	19	iim	iim	PROPN
bam-1791	54	20	meeting	meeting	NOUN
bam-1791	54	21	,	,	PUNCT
bam-1791	54	22	acaya	acaya	NOUN
bam-1791	54	23	(	(	PUNCT
bam-1791	54	24	lecce	lecce	PROPN
bam-1791	54	25	)	)	PUNCT
bam-1791	54	26	,	,	PUNCT
bam-1791	54	27	october	october	PROPN
bam-1791	54	28	12	12	NUM
bam-1791	54	29	-	-	SYM
bam-1791	54	30	14	14	NUM
bam-1791	54	31	,	,	PUNCT
bam-1791	54	32	2012	2012	NUM
bam-1791	54	33	european	european	PROPN
bam-1791	54	34	journal	journal	PROPN
bam-1791	54	35	translational	translational	ADJ
bam-1791	54	36	myology	myology	NOUN
bam-1791	54	37	basic	basic	ADJ
bam-1791	54	38	applied	apply	VERB
bam-1791	54	39	myology	myology	NOUN
bam-1791	54	40	2012	2012	NUM
bam-1791	54	41	;	;	PUNCT
bam-1791	54	42	22(1&2	22(1&2	NUM
bam-1791	54	43	):	):	PUNCT
bam-1791	54	44	xxx	xxx	NOUN
bam-1791	54	45	-	-	PUNCT
bam-1791	54	46	xxx	xxx	NOUN
bam-1791	54	47	22	22	NUM
bam-1791	54	48	(	(	PUNCT
bam-1791	54	49	icm	icm	NOUN
bam-1791	54	50	)	)	PUNCT
bam-1791	54	51	from	from	ADP
bam-1791	54	52	grmd	grmd	PROPN
bam-1791	54	53	(	(	PUNCT
bam-1791	54	54	golden	golden	ADJ
bam-1791	54	55	retriever	retriever	NOUN
bam-1791	54	56	muscular	muscular	ADJ
bam-1791	54	57	dystrophy	dystrophy	NOUN
bam-1791	54	58	)	)	PUNCT
bam-1791	54	59	and	and	CCONJ
bam-1791	54	60	healthy	healthy	ADJ
bam-1791	54	61	dogs	dog	NOUN
bam-1791	54	62	.	.	PUNCT
bam-1791	55	1	for	for	ADP
bam-1791	55	2	this	this	DET
bam-1791	55	3	purpose	purpose	NOUN
bam-1791	55	4	we	we	PRON
bam-1791	55	5	used	use	VERB
bam-1791	55	6	a	a	DET
bam-1791	55	7	mix	mix	NOUN
bam-1791	55	8	of	of	ADP
bam-1791	55	9	transcription	transcription	NOUN
bam-1791	55	10	factors	factor	NOUN
bam-1791	55	11	(	(	PUNCT
bam-1791	55	12	gata4	gata4	NOUN
bam-1791	55	13	,	,	PUNCT
bam-1791	55	14	tbx5	tbx5	NOUN
bam-1791	55	15	,	,	PUNCT
bam-1791	55	16	mef2c	mef2c	PROPN
bam-1791	55	17	)	)	PUNCT
bam-1791	55	18	,	,	PUNCT
bam-1791	55	19	successfully	successfully	ADV
bam-1791	55	20	used	use	VERB
bam-1791	55	21	to	to	PART
bam-1791	55	22	transdifferentiate	transdifferentiate	VERB
bam-1791	55	23	mouse	mouse	NOUN
bam-1791	55	24	fibroblasts	fibroblast	NOUN
bam-1791	55	25	into	into	ADP
bam-1791	55	26	cardiomyocytes	cardiomyocyte	NOUN
bam-1791	55	27	.	.	PUNCT
bam-1791	56	1	exogenous	exogenous	ADJ
bam-1791	56	2	gene	gene	NOUN
bam-1791	56	3	expression	expression	NOUN
bam-1791	56	4	was	be	AUX
bam-1791	56	5	obtained	obtain	VERB
bam-1791	56	6	using	use	VERB
bam-1791	56	7	three	three	NUM
bam-1791	56	8	lentiviral	lentiviral	ADJ
bam-1791	56	9	vectors	vector	NOUN
bam-1791	56	10	carrying	carry	VERB
bam-1791	56	11	the	the	DET
bam-1791	56	12	transcription	transcription	NOUN
bam-1791	56	13	factor	factor	NOUN
bam-1791	56	14	genes	gene	NOUN
bam-1791	56	15	and	and	CCONJ
bam-1791	56	16	different	different	ADJ
bam-1791	56	17	resistance	resistance	NOUN
bam-1791	56	18	genes	gene	NOUN
bam-1791	56	19	.	.	PUNCT
bam-1791	57	1	a	a	DET
bam-1791	57	2	tracer	tracer	NOUN
bam-1791	57	3	gene	gene	NOUN
bam-1791	57	4	of	of	ADP
bam-1791	57	5	cardiac	cardiac	ADJ
bam-1791	57	6	differentiation	differentiation	NOUN
bam-1791	57	7	was	be	AUX
bam-1791	57	8	also	also	ADV
bam-1791	57	9	included	include	VERB
bam-1791	57	10	for	for	ADP
bam-1791	57	11	in	in	ADP
bam-1791	57	12	vivo	vivo	ADJ
bam-1791	57	13	experiments	experiment	NOUN
bam-1791	57	14	(	(	PUNCT
bam-1791	57	15	αmhc	αmhc	NOUN
bam-1791	57	16	-	-	PUNCT
bam-1791	57	17	gfp	gfp	NOUN
bam-1791	57	18	)	)	PUNCT
bam-1791	57	19	.	.	PUNCT
bam-1791	58	1	it	it	PRON
bam-1791	58	2	has	have	AUX
bam-1791	58	3	been	be	AUX
bam-1791	58	4	shown	show	VERB
bam-1791	58	5	by	by	ADP
bam-1791	58	6	srivastava	srivastava	PROPN
bam-1791	58	7	group	group	PROPN
bam-1791	58	8	that	that	SCONJ
bam-1791	58	9	the	the	DET
bam-1791	58	10	same	same	ADJ
bam-1791	58	11	mix	mix	NOUN
bam-1791	58	12	of	of	ADP
bam-1791	58	13	transcription	transcription	NOUN
bam-1791	58	14	factors	factor	NOUN
bam-1791	58	15	can	can	AUX
bam-1791	58	16	drive	drive	VERB
bam-1791	58	17	transdifferentiation	transdifferentiation	NOUN
bam-1791	58	18	of	of	ADP
bam-1791	58	19	mouse	mouse	NOUN
bam-1791	58	20	fibroblasts	fibroblast	NOUN
bam-1791	58	21	into	into	ADP
bam-1791	58	22	cardiomyocyte	cardiomyocyte	PROPN
bam-1791	58	23	.	.	PUNCT
bam-1791	59	1	in	in	ADP
bam-1791	59	2	our	our	PRON
bam-1791	59	3	hand	hand	NOUN
bam-1791	59	4	the	the	DET
bam-1791	59	5	expression	expression	NOUN
bam-1791	59	6	of	of	ADP
bam-1791	59	7	those	those	DET
bam-1791	59	8	transcription	transcription	NOUN
bam-1791	59	9	factors	factor	NOUN
bam-1791	59	10	induced	induce	VERB
bam-1791	59	11	the	the	DET
bam-1791	59	12	expression	expression	NOUN
bam-1791	59	13	of	of	ADP
bam-1791	59	14	late	late	ADJ
bam-1791	59	15	cardiac	cardiac	ADJ
bam-1791	59	16	markers	marker	NOUN
bam-1791	59	17	in	in	ADP
bam-1791	59	18	skin	skin	NOUN
bam-1791	59	19	canine	canine	NOUN
bam-1791	59	20	fibroblasts	fibroblast	NOUN
bam-1791	59	21	.	.	PUNCT
bam-1791	60	1	our	our	PRON
bam-1791	60	2	experiments	experiment	NOUN
bam-1791	60	3	demonstrate	demonstrate	VERB
bam-1791	60	4	a	a	DET
bam-1791	60	5	direct	direct	ADJ
bam-1791	60	6	switch	switch	NOUN
bam-1791	60	7	from	from	ADP
bam-1791	60	8	fibroblast	fibroblast	NOUN
bam-1791	60	9	to	to	ADP
bam-1791	60	10	icm	icm	NOUN
bam-1791	60	11	without	without	ADP
bam-1791	60	12	any	any	DET
bam-1791	60	13	involvement	involvement	NOUN
bam-1791	60	14	of	of	ADP
bam-1791	60	15	early	early	ADJ
bam-1791	60	16	cardiac	cardiac	ADJ
bam-1791	60	17	genes	gene	NOUN
bam-1791	60	18	.	.	PUNCT
bam-1791	61	1	however	however	ADV
bam-1791	61	2	,	,	PUNCT
bam-1791	61	3	icm	icm	PROPN
bam-1791	61	4	were	be	AUX
bam-1791	61	5	unable	unable	ADJ
bam-1791	61	6	to	to	PART
bam-1791	61	7	contract	contract	VERB
bam-1791	61	8	spontaneously	spontaneously	ADV
bam-1791	61	9	.	.	PUNCT
bam-1791	62	1	this	this	PRON
bam-1791	62	2	was	be	AUX
bam-1791	62	3	probably	probably	ADV
bam-1791	62	4	due	due	ADJ
bam-1791	62	5	to	to	ADP
bam-1791	62	6	an	an	DET
bam-1791	62	7	incomplete	incomplete	ADJ
bam-1791	62	8	transdifferentiation	transdifferentiation	NOUN
bam-1791	62	9	process	process	NOUN
bam-1791	62	10	.	.	PUNCT
bam-1791	63	1	in	in	ADP
bam-1791	63	2	vivo	vivo	ADJ
bam-1791	63	3	experiments	experiment	NOUN
bam-1791	63	4	demonstrate	demonstrate	VERB
bam-1791	63	5	that	that	SCONJ
bam-1791	63	6	icm	icm	PROPN
bam-1791	63	7	can	can	AUX
bam-1791	63	8	engraft	engraft	VERB
bam-1791	63	9	in	in	ADP
bam-1791	63	10	the	the	DET
bam-1791	63	11	heart	heart	NOUN
bam-1791	63	12	of	of	ADP
bam-1791	63	13	scid	scid	PROPN
bam-1791	63	14	/	/	SYM
bam-1791	63	15	beige	beige	ADJ
bam-1791	63	16	newborn	newborn	ADJ
bam-1791	63	17	mice	mouse	NOUN
bam-1791	63	18	.	.	PUNCT
bam-1791	64	1	however	however	ADV
bam-1791	64	2	,	,	PUNCT
bam-1791	64	3	further	far	ADV
bam-1791	64	4	electrophysiological	electrophysiological	ADJ
bam-1791	64	5	analyses	analysis	NOUN
bam-1791	64	6	are	be	AUX
bam-1791	64	7	necessary	necessary	ADJ
bam-1791	64	8	to	to	PART
bam-1791	64	9	confirm	confirm	VERB
bam-1791	64	10	ion	ion	NOUN
bam-1791	64	11	channel	channel	NOUN
bam-1791	64	12	functionality	functionality	NOUN
bam-1791	64	13	of	of	ADP
bam-1791	64	14	transplanted	transplanted	ADJ
bam-1791	64	15	icm	icm	PROPN
bam-1791	64	16	.	.	PUNCT
bam-1791	65	1	aknowledgement	aknowledgement	NOUN
bam-1791	65	2	:	:	PUNCT
bam-1791	65	3	this	this	DET
bam-1791	65	4	work	work	NOUN
bam-1791	65	5	is	be	AUX
bam-1791	65	6	funded	fund	VERB
bam-1791	65	7	by	by	ADP
bam-1791	65	8	the	the	DET
bam-1791	65	9	ku	ku	PROPN
bam-1791	65	10	leuven	leuven	PROPN
bam-1791	65	11	program	program	PROPN
bam-1791	65	12	financing	financing	NOUN
bam-1791	65	13	(	(	PUNCT
bam-1791	65	14	2010	2010	NUM
bam-1791	65	15	-	-	SYM
bam-1791	65	16	2017	2017	NUM
bam-1791	65	17	)	)	PUNCT
bam-1791	65	18	and	and	CCONJ
bam-1791	65	19	in	in	ADP
bam-1791	65	20	part	part	NOUN
bam-1791	65	21	by	by	ADP
bam-1791	65	22	care	care	NOUN
bam-1791	65	23	-	-	PUNCT
bam-1791	65	24	mi	mi	NOUN
bam-1791	65	25	fp7	fp7	PROPN
bam-1791	65	26	#	#	SYM
bam-1791	65	27	242038	242038	NUM
bam-1791	65	28	european	european	ADJ
bam-1791	65	29	grant	grant	NOUN
bam-1791	65	30	.	.	PUNCT
bam-1791	66	1	6	6	X
bam-1791	66	2	.	.	X
bam-1791	66	3	adenosine	adenosine	NOUN
bam-1791	66	4	-	-	PUNCT
bam-1791	66	5	mediated	mediate	VERB
bam-1791	66	6	modulation	modulation	NOUN
bam-1791	66	7	of	of	ADP
bam-1791	66	8	the	the	DET
bam-1791	66	9	nachr	nachr	NOUN
bam-1791	66	10	-	-	PUNCT
bam-1791	66	11	dependent	dependent	ADJ
bam-1791	67	1	[	[	X
bam-1791	67	2	ca2+]i	ca2+]i	NOUN
bam-1791	67	3	oscillations	oscillation	NOUN
bam-1791	67	4	in	in	ADP
bam-1791	67	5	developing	develop	VERB
bam-1791	67	6	skeletal	skeletal	ADJ
bam-1791	67	7	muscle	muscle	NOUN
bam-1791	67	8	cells	cell	NOUN
bam-1791	67	9	parato	parato	PROPN
bam-1791	67	10	g.	g.	PROPN
bam-1791	67	11	,	,	PUNCT
bam-1791	67	12	bernareggi	bernareggi	PROPN
bam-1791	67	13	a.	a.	PROPN
bam-1791	67	14	,	,	PUNCT
bam-1791	67	15	luin	luin	PROPN
bam-1791	67	16	e.	e.	PROPN
bam-1791	67	17	,	,	PUNCT
bam-1791	67	18	sciancalepore	sciancalepore	ADJ
bam-1791	67	19	m.	m.	NOUN
bam-1791	67	20	,	,	PUNCT
bam-1791	67	21	lorenzon	lorenzon	PROPN
bam-1791	67	22	p.	p.	PROPN
bam-1791	67	23	department	department	PROPN
bam-1791	67	24	of	of	ADP
bam-1791	67	25	life	life	PROPN
bam-1791	67	26	sciences	sciences	PROPN
bam-1791	67	27	and	and	CCONJ
bam-1791	67	28	centre	centre	NOUN
bam-1791	67	29	for	for	ADP
bam-1791	67	30	neuroscience	neuroscience	NOUN
bam-1791	67	31	b.r.a.i.n	b.r.a.i.n	NOUN
bam-1791	67	32	.	.	PUNCT
bam-1791	67	33	,	,	PUNCT
bam-1791	67	34	university	university	PROPN
bam-1791	67	35	of	of	ADP
bam-1791	67	36	trieste	trieste	PROPN
bam-1791	67	37	,	,	PUNCT
bam-1791	67	38	trieste	trieste	PROPN
bam-1791	67	39	,	,	PUNCT
bam-1791	67	40	italy	italy	NOUN
bam-1791	67	41	adenosine	adenosine	NOUN
bam-1791	67	42	receptors	receptor	NOUN
bam-1791	67	43	(	(	PUNCT
bam-1791	67	44	ars	ar	NOUN
bam-1791	67	45	)	)	PUNCT
bam-1791	67	46	are	be	AUX
bam-1791	67	47	classified	classify	VERB
bam-1791	67	48	into	into	ADP
bam-1791	67	49	different	different	ADJ
bam-1791	67	50	subtypes	subtype	NOUN
bam-1791	67	51	(	(	PUNCT
bam-1791	67	52	a1	a1	NOUN
bam-1791	67	53	,	,	PUNCT
bam-1791	67	54	a2a	a2a	PROPN
bam-1791	67	55	,	,	PUNCT
bam-1791	67	56	a2b	a2b	PROPN
bam-1791	67	57	and	and	CCONJ
bam-1791	67	58	a3rs	a3rs	NOUN
bam-1791	67	59	)	)	PUNCT
bam-1791	67	60	and	and	CCONJ
bam-1791	67	61	are	be	AUX
bam-1791	67	62	expressed	express	VERB
bam-1791	67	63	in	in	ADP
bam-1791	67	64	neurons	neuron	NOUN
bam-1791	67	65	and	and	CCONJ
bam-1791	67	66	skeletal	skeletal	ADJ
bam-1791	67	67	muscle	muscle	NOUN
bam-1791	67	68	cells	cell	NOUN
bam-1791	67	69	.	.	PUNCT
bam-1791	68	1	in	in	ADP
bam-1791	68	2	the	the	DET
bam-1791	68	3	skeletal	skeletal	ADJ
bam-1791	68	4	muscle	muscle	NOUN
bam-1791	68	5	ars	ar	NOUN
bam-1791	68	6	modulate	modulate	VERB
bam-1791	68	7	the	the	DET
bam-1791	68	8	blood	blood	NOUN
bam-1791	68	9	flow	flow	NOUN
bam-1791	68	10	,	,	PUNCT
bam-1791	68	11	the	the	DET
bam-1791	68	12	glucose	glucose	NOUN
bam-1791	68	13	uptake	uptake	ADJ
bam-1791	68	14	and	and	CCONJ
bam-1791	68	15	the	the	DET
bam-1791	68	16	contractile	contractile	NOUN
bam-1791	68	17	force	force	NOUN
bam-1791	68	18	.	.	PUNCT
bam-1791	69	1	in	in	ADP
bam-1791	69	2	developing	develop	VERB
bam-1791	69	3	mouse	mouse	NOUN
bam-1791	69	4	myotubes	myotube	NOUN
bam-1791	69	5	,	,	PUNCT
bam-1791	69	6	before	before	ADP
bam-1791	69	7	innervation	innervation	NOUN
bam-1791	69	8	,	,	PUNCT
bam-1791	69	9	the	the	DET
bam-1791	69	10	autocrine	autocrine	NOUN
bam-1791	69	11	activation	activation	NOUN
bam-1791	69	12	of	of	ADP
bam-1791	69	13	embryonic	embryonic	ADJ
bam-1791	69	14	nicotinic	nicotinic	ADJ
bam-1791	69	15	acetylcholine	acetylcholine	NOUN
bam-1791	69	16	receptors	receptor	NOUN
bam-1791	69	17	(	(	PUNCT
bam-1791	69	18	nachrs	nachrs	ADJ
bam-1791	69	19	)	)	PUNCT
bam-1791	69	20	triggers	trigger	VERB
bam-1791	69	21	spontaneous	spontaneous	ADJ
bam-1791	69	22	[	[	X
bam-1791	69	23	ca2+]i	ca2+]i	NOUN
bam-1791	69	24	oscillation	oscillation	NOUN
bam-1791	69	25	and	and	CCONJ
bam-1791	69	26	contractile	contractile	NOUN
bam-1791	69	27	activity	activity	NOUN
bam-1791	69	28	.	.	PUNCT
bam-1791	70	1	taking	take	VERB
bam-1791	70	2	into	into	ADP
bam-1791	70	3	account	account	NOUN
bam-1791	70	4	that	that	SCONJ
bam-1791	70	5	adenosine	adenosine	NOUN
bam-1791	70	6	acts	act	NOUN
bam-1791	70	7	as	as	ADP
bam-1791	70	8	a	a	DET
bam-1791	70	9	neuromodulator	neuromodulator	NOUN
bam-1791	70	10	in	in	ADP
bam-1791	70	11	central	central	ADJ
bam-1791	70	12	nervous	nervous	ADJ
bam-1791	70	13	system	system	NOUN
bam-1791	70	14	,	,	PUNCT
bam-1791	70	15	here	here	ADV
bam-1791	70	16	we	we	PRON
bam-1791	70	17	investigated	investigate	VERB
bam-1791	70	18	the	the	DET
bam-1791	70	19	possible	possible	ADJ
bam-1791	70	20	functional	functional	ADJ
bam-1791	70	21	interplay	interplay	NOUN
bam-1791	70	22	between	between	ADP
bam-1791	70	23	ars	ar	NOUN
bam-1791	70	24	and	and	CCONJ
bam-1791	70	25	embryonic	embryonic	VERB
bam-1791	70	26	nachrs	nachrs	ADV
bam-1791	70	27	during	during	ADP
bam-1791	70	28	myogenesis	myogenesis	NOUN
bam-1791	70	29	.	.	PUNCT
bam-1791	71	1	videoimaging	videoimage	VERB
bam-1791	71	2	experiments	experiment	NOUN
bam-1791	71	3	revealed	reveal	VERB
bam-1791	71	4	that	that	SCONJ
bam-1791	71	5	the	the	DET
bam-1791	71	6	ar	ar	NOUN
bam-1791	71	7	antagonist	antagonist	NOUN
bam-1791	71	8	cgs	cgs	NOUN
bam-1791	71	9	15943	15943	NUM
bam-1791	71	10	(	(	PUNCT
bam-1791	71	11	100	100	NUM
bam-1791	71	12	nm	nm	NOUN
bam-1791	71	13	)	)	PUNCT
bam-1791	71	14	blocked	block	VERB
bam-1791	71	15	spontaneous	spontaneous	ADJ
bam-1791	72	1	[	[	X
bam-1791	72	2	ca2+]i	ca2+]i	NOUN
bam-1791	72	3	oscillations	oscillation	NOUN
bam-1791	72	4	.	.	PUNCT
bam-1791	73	1	viceversa	viceversa	PROPN
bam-1791	73	2	,	,	PUNCT
bam-1791	73	3	the	the	DET
bam-1791	73	4	ar	ar	PROPN
bam-1791	73	5	agonist	agonist	PROPN
bam-1791	73	6	neca	neca	NOUN
bam-1791	73	7	(	(	PUNCT
bam-1791	73	8	100	100	NUM
bam-1791	73	9	μm	μm	NUM
bam-1791	73	10	)	)	PUNCT
bam-1791	73	11	induced	induce	VERB
bam-1791	73	12	an	an	DET
bam-1791	73	13	increase	increase	NOUN
bam-1791	73	14	in	in	ADP
bam-1791	73	15	the	the	DET
bam-1791	73	16	percentage	percentage	NOUN
bam-1791	73	17	of	of	ADP
bam-1791	73	18	oscillating	oscillate	VERB
bam-1791	73	19	cells	cell	NOUN
bam-1791	73	20	and	and	CCONJ
bam-1791	73	21	in	in	ADP
bam-1791	73	22	the	the	DET
bam-1791	73	23	frequency	frequency	NOUN
bam-1791	73	24	of	of	ADP
bam-1791	73	25	ca2	ca2	PROPN
bam-1791	73	26	+	+	PROPN
bam-1791	73	27	events	event	NOUN
bam-1791	73	28	.	.	PUNCT
bam-1791	74	1	in	in	ADP
bam-1791	74	2	parallel	parallel	ADJ
bam-1791	74	3	,	,	PUNCT
bam-1791	74	4	electrophysiological	electrophysiological	ADJ
bam-1791	74	5	recordings	recording	NOUN
bam-1791	74	6	performed	perform	VERB
bam-1791	74	7	in	in	ADP
bam-1791	74	8	the	the	DET
bam-1791	74	9	cell	cell	NOUN
bam-1791	74	10	-	-	PUNCT
bam-1791	74	11	attached	attach	VERB
bam-1791	74	12	configuration	configuration	NOUN
bam-1791	74	13	indicated	indicate	VERB
bam-1791	74	14	that	that	SCONJ
bam-1791	74	15	cgs15943	cgs15943	VERB
bam-1791	74	16	reduced	reduce	VERB
bam-1791	74	17	the	the	DET
bam-1791	74	18	nachr	nachr	NOUN
bam-1791	74	19	mean	mean	VERB
bam-1791	74	20	open	open	ADJ
bam-1791	74	21	time	time	NOUN
bam-1791	74	22	,	,	PUNCT
bam-1791	74	23	whereas	whereas	SCONJ
bam-1791	74	24	neca	neca	PROPN
bam-1791	74	25	significantly	significantly	ADV
bam-1791	74	26	increased	increase	VERB
bam-1791	74	27	it	it	PRON
bam-1791	74	28	.	.	PUNCT
bam-1791	75	1	in	in	ADP
bam-1791	75	2	addition	addition	NOUN
bam-1791	75	3	,	,	PUNCT
bam-1791	75	4	electrophysiological	electrophysiological	ADJ
bam-1791	75	5	recordings	recording	NOUN
bam-1791	75	6	in	in	ADP
bam-1791	75	7	oocytes	oocyte	NOUN
bam-1791	75	8	injected	inject	VERB
bam-1791	75	9	with	with	ADP
bam-1791	75	10	denervated	denervate	VERB
bam-1791	75	11	skeletal	skeletal	ADJ
bam-1791	75	12	muscle	muscle	NOUN
bam-1791	75	13	membranes	membrane	NOUN
bam-1791	75	14	showed	show	VERB
bam-1791	75	15	that	that	SCONJ
bam-1791	75	16	the	the	DET
bam-1791	75	17	activation	activation	NOUN
bam-1791	75	18	of	of	ADP
bam-1791	75	19	ars	ar	NOUN
bam-1791	75	20	reduced	reduce	VERB
bam-1791	75	21	the	the	DET
bam-1791	75	22	nachrcurrent	nachrcurrent	ADJ
bam-1791	75	23	rundown	rundown	NOUN
bam-1791	75	24	and	and	CCONJ
bam-1791	75	25	slowed	slow	VERB
bam-1791	75	26	the	the	DET
bam-1791	75	27	nach	nach	NOUN
bam-1791	75	28	-	-	PUNCT
bam-1791	75	29	current	current	ADJ
bam-1791	75	30	decay	decay	NOUN
bam-1791	75	31	,	,	PUNCT
bam-1791	75	32	while	while	SCONJ
bam-1791	75	33	the	the	DET
bam-1791	75	34	ar	ar	NOUN
bam-1791	75	35	inhibition	inhibition	NOUN
bam-1791	75	36	elicited	elicit	VERB
bam-1791	75	37	the	the	DET
bam-1791	75	38	opposite	opposite	ADJ
bam-1791	75	39	effect	effect	NOUN
bam-1791	75	40	.	.	PUNCT
bam-1791	76	1	these	these	DET
bam-1791	76	2	preliminary	preliminary	ADJ
bam-1791	76	3	results	result	NOUN
bam-1791	76	4	suggest	suggest	VERB
bam-1791	76	5	a	a	DET
bam-1791	76	6	modulatory	modulatory	ADJ
bam-1791	76	7	effect	effect	NOUN
bam-1791	76	8	of	of	ADP
bam-1791	76	9	ar	ar	NOUN
bam-1791	76	10	activity	activity	NOUN
bam-1791	76	11	on	on	ADP
bam-1791	76	12	the	the	DET
bam-1791	76	13	embryonic	embryonic	ADJ
bam-1791	76	14	nachr	nachr	PROPN
bam-1791	76	15	function	function	NOUN
bam-1791	76	16	in	in	ADP
bam-1791	76	17	developing	develop	VERB
bam-1791	76	18	mouse	mouse	NOUN
bam-1791	76	19	myotubes	myotube	NOUN
bam-1791	76	20	.	.	PUNCT
bam-1791	77	1	we	we	PRON
bam-1791	77	2	hypothesize	hypothesize	VERB
bam-1791	77	3	a	a	DET
bam-1791	77	4	new	new	ADJ
bam-1791	77	5	potential	potential	ADJ
bam-1791	77	6	role	role	NOUN
bam-1791	77	7	for	for	ADP
bam-1791	77	8	ars	ar	NOUN
bam-1791	77	9	in	in	ADP
bam-1791	77	10	the	the	DET
bam-1791	77	11	regulation	regulation	NOUN
bam-1791	77	12	of	of	ADP
bam-1791	77	13	nachr	nachr	NOUN
bam-1791	77	14	-	-	PUNCT
bam-1791	77	15	mediated	mediate	VERB
bam-1791	77	16	events	event	NOUN
bam-1791	77	17	during	during	ADP
bam-1791	77	18	skeletal	skeletal	ADJ
bam-1791	77	19	muscle	muscle	NOUN
bam-1791	77	20	differentiation	differentiation	NOUN
bam-1791	77	21	/	/	SYM
bam-1791	77	22	regeneration	regeneration	NOUN
bam-1791	77	23	.	.	PUNCT
bam-1791	78	1	session	session	NOUN
bam-1791	78	2	2	2	NUM
bam-1791	78	3	satellite	satellite	NOUN
bam-1791	78	4	cells	cell	NOUN
bam-1791	78	5	and	and	CCONJ
bam-1791	78	6	muscle	muscle	NOUN
bam-1791	78	7	regeneration	regeneration	NOUN
bam-1791	78	8	7	7	NUM
bam-1791	78	9	.	.	PUNCT
bam-1791	79	1	mirnas	mirna	NOUN
bam-1791	79	2	regulation	regulation	NOUN
bam-1791	79	3	in	in	ADP
bam-1791	79	4	human	human	ADJ
bam-1791	79	5	satellite	satellite	NOUN
bam-1791	79	6	cells	cell	NOUN
bam-1791	79	7	subjected	subject	VERB
bam-1791	79	8	to	to	ADP
bam-1791	79	9	hypoxic	hypoxic	ADJ
bam-1791	79	10	environment	environment	NOUN
bam-1791	79	11	1a,3ester	1a,3ester	PROPN
bam-1791	79	12	sara	sara	PROPN
bam-1791	79	13	di	di	X
bam-1791	79	14	filippo	filippo	PROPN
bam-1791	79	15	,	,	PUNCT
bam-1791	79	16	1b,3tiziana	1b,3tiziana	PROPN
bam-1791	79	17	pietrangelo	pietrangelo	NOUN
bam-1791	79	18	,	,	PUNCT
bam-1791	79	19	1a,3rosa	1a,3rosa	NUM
bam-1791	79	20	mancinelli	mancinelli	NOUN
bam-1791	79	21	,	,	PUNCT
bam-1791	79	22	1a,3rita	1a,3rita	PROPN
bam-1791	79	23	maria	maria	PROPN
bam-1791	79	24	laura	laura	PROPN
bam-1791	79	25	la	la	PROPN
bam-1791	79	26	rovere	rovere	PROPN
bam-1791	79	27	,	,	PUNCT
bam-1791	79	28	1b,3giorgio	1b,3giorgio	NUM
bam-1791	79	29	fanò	fanò	NOUN
bam-1791	79	30	,	,	PUNCT
bam-1791	79	31	2,3maurilio	2,3maurilio	NUM
bam-1791	79	32	sampaolesi	sampaolesi	NOUN
bam-1791	79	33	,	,	PUNCT
bam-1791	79	34	1a,3stefania	1a,3stefania	PROPN
bam-1791	79	35	fulle	fulle	NOUN
bam-1791	79	36	1dept	1dept	NUM
bam-1791	79	37	.	.	PUNCT
bam-1791	79	38	neuroscience	neuroscience	NOUN
bam-1791	79	39	and	and	CCONJ
bam-1791	79	40	imaging	imaging	NOUN
bam-1791	79	41	,	,	PUNCT
bam-1791	79	42	ace.s.i	ace.s.i	PROPN
bam-1791	79	43	.	.	PUNCT
bam-1791	80	1	(	(	PUNCT
bam-1791	80	2	center	center	NOUN
bam-1791	80	3	for	for	ADP
bam-1791	80	4	excellence	excellence	NOUN
bam-1791	80	5	on	on	ADP
bam-1791	80	6	ageing	age	VERB
bam-1791	80	7	)	)	PUNCT
bam-1791	80	8	,	,	PUNCT
bam-1791	80	9	bcrc	bcrc	NOUN
bam-1791	80	10	(	(	PUNCT
bam-1791	80	11	clinical	clinical	ADJ
bam-1791	80	12	research	research	NOUN
bam-1791	80	13	center	center	NOUN
bam-1791	80	14	)	)	PUNCT
bam-1791	80	15	–	–	PUNCT
bam-1791	80	16	university	university	NOUN
bam-1791	80	17	“	"	PUNCT
bam-1791	80	18	g.	g.	PROPN
bam-1791	80	19	d’annunzio	d’annunzio	PROPN
bam-1791	80	20	”	"	PUNCT
bam-1791	80	21	chieti	chieti	PROPN
bam-1791	80	22	-	-	PUNCT
bam-1791	80	23	pescara	pescara	PROPN
bam-1791	80	24	,	,	PUNCT
bam-1791	80	25	via	via	ADP
bam-1791	80	26	dei	dei	NOUN
bam-1791	80	27	vestini	vestini	NOUN
bam-1791	80	28	,	,	PUNCT
bam-1791	80	29	29	29	NUM
bam-1791	80	30	66013	66013	NUM
bam-1791	80	31	chieti	chieti	NOUN
bam-1791	80	32	;	;	PUNCT
bam-1791	80	33	2laboratory	2laboratory	NUM
bam-1791	80	34	of	of	ADP
bam-1791	80	35	translational	translational	ADJ
bam-1791	80	36	cardiomyology	cardiomyology	NOUN
bam-1791	80	37	,	,	PUNCT
bam-1791	80	38	scil	scil	PROPN
bam-1791	80	39	,	,	PUNCT
bam-1791	80	40	dept	dept	NOUN
bam-1791	80	41	.	.	PROPN
bam-1791	80	42	of	of	ADP
bam-1791	80	43	development	development	NOUN
bam-1791	80	44	and	and	CCONJ
bam-1791	80	45	regeneration	regeneration	NOUN
bam-1791	80	46	,	,	PUNCT
bam-1791	80	47	katholieke	katholieke	PROPN
bam-1791	80	48	universiteit	universiteit	PROPN
bam-1791	80	49	leuven	leuven	PROPN
bam-1791	80	50	,	,	PUNCT
bam-1791	80	51	herestraat	herestraat	X
bam-1791	81	1	49	49	NUM
bam-1791	81	2	o&n4	o&n4	PROPN
bam-1791	81	3	bus	bus	NOUN
bam-1791	81	4	814	814	NUM
bam-1791	81	5	,	,	PUNCT
bam-1791	81	6	3000	3000	NUM
bam-1791	81	7	leuven	leuven	NOUN
bam-1791	81	8	,	,	PUNCT
bam-1791	81	9	belgium	belgium	NOUN
bam-1791	81	10	;	;	PUNCT
bam-1791	81	11	3iim	3iim	NUM
bam-1791	81	12	–	–	PUNCT
bam-1791	81	13	interuniversity	interuniversity	NOUN
bam-1791	81	14	institute	institute	NOUN
bam-1791	81	15	of	of	ADP
bam-1791	81	16	myology	myology	NOUN
bam-1791	81	17	hypoxia	hypoxia	NOUN
bam-1791	81	18	is	be	AUX
bam-1791	81	19	an	an	DET
bam-1791	81	20	aberrantly	aberrantly	ADV
bam-1791	81	21	low	low	ADJ
bam-1791	81	22	oxygen	oxygen	NOUN
bam-1791	81	23	content	content	NOUN
bam-1791	81	24	in	in	ADP
bam-1791	81	25	cells	cell	NOUN
bam-1791	81	26	,	,	PUNCT
bam-1791	81	27	tissues	tissue	NOUN
bam-1791	81	28	or	or	CCONJ
bam-1791	81	29	organs	organ	NOUN
bam-1791	81	30	,	,	PUNCT
bam-1791	81	31	generally	generally	ADV
bam-1791	81	32	due	due	ADJ
bam-1791	81	33	to	to	ADP
bam-1791	81	34	the	the	DET
bam-1791	81	35	decrease	decrease	NOUN
bam-1791	81	36	in	in	ADP
bam-1791	81	37	the	the	DET
bam-1791	81	38	atmosphere	atmosphere	NOUN
bam-1791	81	39	oxygen	oxygen	NOUN
bam-1791	81	40	pressure	pressure	NOUN
bam-1791	81	41	.	.	PUNCT
bam-1791	82	1	the	the	DET
bam-1791	82	2	normal	normal	ADJ
bam-1791	82	3	composition	composition	NOUN
bam-1791	82	4	of	of	ADP
bam-1791	82	5	the	the	DET
bam-1791	82	6	air	air	NOUN
bam-1791	82	7	(	(	PUNCT
bam-1791	82	8	78	78	NUM
bam-1791	82	9	%	%	NOUN
bam-1791	82	10	n2	n2	NOUN
bam-1791	82	11	,	,	PUNCT
bam-1791	82	12	21	21	NUM
bam-1791	82	13	%	%	NOUN
bam-1791	82	14	o2	o2	ADJ
bam-1791	82	15	and	and	CCONJ
bam-1791	82	16	1	1	NUM
bam-1791	82	17	%	%	NOUN
bam-1791	82	18	trace	trace	NOUN
bam-1791	82	19	gases	gas	NOUN
bam-1791	82	20	)	)	PUNCT
bam-1791	82	21	can	can	AUX
bam-1791	82	22	be	be	AUX
bam-1791	82	23	slightly	slightly	ADV
bam-1791	82	24	modified	modify	VERB
bam-1791	82	25	according	accord	VERB
bam-1791	82	26	to	to	ADP
bam-1791	82	27	the	the	DET
bam-1791	82	28	altitude	altitude	NOUN
bam-1791	82	29	.	.	PUNCT
bam-1791	83	1	the	the	DET
bam-1791	83	2	physiological	physiological	ADJ
bam-1791	83	3	adaptation	adaptation	NOUN
bam-1791	83	4	of	of	ADP
bam-1791	83	5	skeletal	skeletal	ADJ
bam-1791	83	6	muscle	muscle	NOUN
bam-1791	83	7	tissues	tissue	NOUN
bam-1791	83	8	subjected	subject	VERB
bam-1791	83	9	to	to	ADP
bam-1791	83	10	low	low	ADJ
bam-1791	83	11	oxygen	oxygen	NOUN
bam-1791	83	12	condition	condition	NOUN
bam-1791	83	13	can	can	AUX
bam-1791	83	14	be	be	AUX
bam-1791	83	15	studied	study	VERB
bam-1791	83	16	directly	directly	ADV
bam-1791	83	17	in	in	ADP
bam-1791	83	18	climbers	climber	NOUN
bam-1791	83	19	.	.	PUNCT
bam-1791	84	1	however	however	ADV
bam-1791	84	2	,	,	PUNCT
bam-1791	84	3	myogenic	myogenic	ADJ
bam-1791	84	4	cell	cell	NOUN
bam-1791	84	5	models	model	NOUN
bam-1791	84	6	can	can	AUX
bam-1791	84	7	be	be	AUX
bam-1791	84	8	generated	generate	VERB
bam-1791	84	9	to	to	PART
bam-1791	84	10	specifically	specifically	ADV
bam-1791	84	11	test	test	VERB
bam-1791	84	12	hypoxic	hypoxic	ADJ
bam-1791	84	13	conditions	condition	NOUN
bam-1791	84	14	and	and	CCONJ
bam-1791	84	15	evaluate	evaluate	VERB
bam-1791	84	16	transcriptome	transcriptome	NOUN
bam-1791	84	17	and	and	CCONJ
bam-1791	84	18	microrna	microrna	PROPN
bam-1791	84	19	dysregulations	dysregulations	PROPN
bam-1791	84	20	.	.	PUNCT
bam-1791	85	1	micrornas	microrna	NOUN
bam-1791	85	2	(	(	PUNCT
bam-1791	85	3	mirnas	mirna	NOUN
bam-1791	85	4	)	)	PUNCT
bam-1791	85	5	are	be	AUX
bam-1791	85	6	a	a	DET
bam-1791	85	7	class	class	NOUN
bam-1791	85	8	of	of	ADP
bam-1791	85	9	non	non	ADJ
bam-1791	85	10	-	-	ADJ
bam-1791	85	11	coding	code	VERB
bam-1791	85	12	regulatory	regulatory	ADJ
bam-1791	85	13	rnas	rna	NOUN
bam-1791	85	14	of	of	ADP
bam-1791	85	15	-22	-22	PUNCT
bam-1791	85	16	nucleotides	nucleotide	NOUN
bam-1791	85	17	in	in	ADP
bam-1791	85	18	length	length	NOUN
bam-1791	85	19	.	.	PUNCT
bam-1791	86	1	a	a	DET
bam-1791	86	2	large	large	ADJ
bam-1791	86	3	number	number	NOUN
bam-1791	86	4	of	of	ADP
bam-1791	86	5	micrornas	microrna	NOUN
bam-1791	86	6	is	be	AUX
bam-1791	86	7	positively	positively	ADV
bam-1791	86	8	regulated	regulate	VERB
bam-1791	86	9	in	in	ADP
bam-1791	86	10	response	response	NOUN
bam-1791	86	11	to	to	ADP
bam-1791	86	12	low	low	ADJ
bam-1791	86	13	oxygen	oxygen	NOUN
bam-1791	86	14	.	.	PUNCT
bam-1791	87	1	in	in	ADP
bam-1791	87	2	ix	ix	PROPN
bam-1791	87	3	iim	iim	PROPN
bam-1791	87	4	meeting	meeting	NOUN
bam-1791	87	5	,	,	PUNCT
bam-1791	87	6	acaya	acaya	NOUN
bam-1791	87	7	(	(	PUNCT
bam-1791	87	8	lecce	lecce	PROPN
bam-1791	87	9	)	)	PUNCT
bam-1791	87	10	,	,	PUNCT
bam-1791	87	11	october	october	PROPN
bam-1791	87	12	12	12	NUM
bam-1791	87	13	-	-	SYM
bam-1791	87	14	14	14	NUM
bam-1791	87	15	,	,	PUNCT
bam-1791	87	16	2012	2012	NUM
bam-1791	87	17	european	european	PROPN
bam-1791	87	18	journal	journal	PROPN
bam-1791	87	19	translational	translational	ADJ
bam-1791	87	20	myology	myology	NOUN
bam-1791	87	21	basic	basic	ADJ
bam-1791	87	22	applied	apply	VERB
bam-1791	87	23	myology	myology	NOUN
bam-1791	87	24	2012	2012	NUM
bam-1791	87	25	;	;	PUNCT
bam-1791	87	26	22(1&2	22(1&2	NUM
bam-1791	87	27	):	):	PUNCT
bam-1791	87	28	xxx	xxx	NOUN
bam-1791	87	29	-	-	PUNCT
bam-1791	87	30	xxx	xxx	NOUN
bam-1791	87	31	23	23	NUM
bam-1791	87	32	addition	addition	NOUN
bam-1791	87	33	,	,	PUNCT
bam-1791	87	34	specific	specific	ADJ
bam-1791	87	35	mirnas	mirna	NOUN
bam-1791	87	36	control	control	VERB
bam-1791	87	37	the	the	DET
bam-1791	87	38	expression	expression	NOUN
bam-1791	87	39	of	of	ADP
bam-1791	87	40	myogenic	myogenic	ADJ
bam-1791	87	41	factors	factor	NOUN
bam-1791	87	42	,	,	PUNCT
bam-1791	87	43	i.e.	i.e.	X
bam-1791	87	44	myod	myod	NOUN
bam-1791	87	45	,	,	PUNCT
bam-1791	87	46	myogenin	myogenin	PROPN
bam-1791	87	47	,	,	PUNCT
bam-1791	87	48	myf5	myf5	NOUN
bam-1791	87	49	,	,	PUNCT
bam-1791	87	50	pax3	pax3	NOUN
bam-1791	87	51	and	and	CCONJ
bam-1791	87	52	pax7	pax7	PROPN
bam-1791	87	53	.	.	PUNCT
bam-1791	88	1	in	in	ADP
bam-1791	88	2	this	this	DET
bam-1791	88	3	study	study	NOUN
bam-1791	88	4	,	,	PUNCT
bam-1791	88	5	we	we	PRON
bam-1791	88	6	investigated	investigate	VERB
bam-1791	88	7	the	the	DET
bam-1791	88	8	effects	effect	NOUN
bam-1791	88	9	of	of	ADP
bam-1791	88	10	hypoxia	hypoxia	NOUN
bam-1791	88	11	on	on	ADP
bam-1791	88	12	myogenic	myogenic	ADJ
bam-1791	88	13	-	-	PUNCT
bam-1791	88	14	related	relate	VERB
bam-1791	88	15	mirnas	mirna	NOUN
bam-1791	88	16	using	use	VERB
bam-1791	88	17	a	a	DET
bam-1791	88	18	human	human	ADJ
bam-1791	88	19	satellite	satellite	NOUN
bam-1791	88	20	cell	cell	NOUN
bam-1791	88	21	system	system	NOUN
bam-1791	88	22	.	.	PUNCT
bam-1791	89	1	muscle	muscle	NOUN
bam-1791	89	2	progenitors	progenitor	NOUN
bam-1791	89	3	were	be	AUX
bam-1791	89	4	isolated	isolate	VERB
bam-1791	89	5	from	from	ADP
bam-1791	89	6	vastus	vastus	NOUN
bam-1791	89	7	lateralis	lateralis	NOUN
bam-1791	89	8	biopsies	biopsy	NOUN
bam-1791	89	9	from	from	ADP
bam-1791	89	10	different	different	ADJ
bam-1791	89	11	subjects	subject	NOUN
bam-1791	89	12	,	,	PUNCT
bam-1791	89	13	after	after	SCONJ
bam-1791	89	14	the	the	DET
bam-1791	89	15	informed	informed	ADJ
bam-1791	89	16	consent	consent	NOUN
bam-1791	89	17	was	be	AUX
bam-1791	89	18	obtained	obtain	VERB
bam-1791	89	19	.	.	PUNCT
bam-1791	90	1	we	we	PRON
bam-1791	90	2	cultivated	cultivate	VERB
bam-1791	90	3	satellite	satellite	NOUN
bam-1791	90	4	cells	cell	NOUN
bam-1791	90	5	in	in	ADP
bam-1791	90	6	standard	standard	ADJ
bam-1791	90	7	(	(	PUNCT
bam-1791	90	8	21	21	NUM
bam-1791	90	9	%	%	NOUN
bam-1791	90	10	o2	o2	PROPN
bam-1791	90	11	)	)	PUNCT
bam-1791	90	12	and	and	CCONJ
bam-1791	90	13	in	in	ADP
bam-1791	90	14	hypoxic	hypoxic	ADJ
bam-1791	90	15	(	(	PUNCT
bam-1791	90	16	3%o2	3%o2	NUM
bam-1791	90	17	)	)	PUNCT
bam-1791	90	18	condition	condition	NOUN
bam-1791	90	19	,	,	PUNCT
bam-1791	90	20	evaluating	evaluate	VERB
bam-1791	90	21	mirna	mirna	NOUN
bam-1791	90	22	and	and	CCONJ
bam-1791	90	23	myogenic	myogenic	ADJ
bam-1791	90	24	marker	marker	NOUN
bam-1791	90	25	expression	expression	NOUN
bam-1791	90	26	during	during	ADP
bam-1791	90	27	cell	cell	NOUN
bam-1791	90	28	proliferation	proliferation	NOUN
bam-1791	90	29	and	and	CCONJ
bam-1791	90	30	differentiation	differentiation	NOUN
bam-1791	90	31	.	.	PUNCT
bam-1791	91	1	we	we	PRON
bam-1791	91	2	focused	focus	VERB
bam-1791	91	3	on	on	ADP
bam-1791	91	4	three	three	NUM
bam-1791	91	5	micrornas	microrna	NOUN
bam-1791	91	6	specifically	specifically	ADV
bam-1791	91	7	expressed	express	VERB
bam-1791	91	8	in	in	ADP
bam-1791	91	9	muscle	muscle	NOUN
bam-1791	91	10	tissue	tissue	NOUN
bam-1791	91	11	,	,	PUNCT
bam-1791	91	12	mir-1	mir-1	ADV
bam-1791	91	13	,	,	PUNCT
bam-1791	91	14	mir-133b	mir-133b	PROPN
bam-1791	91	15	,	,	PUNCT
bam-1791	91	16	and	and	CCONJ
bam-1791	91	17	mir-206	mir-206	NOUN
bam-1791	91	18	.	.	PUNCT
bam-1791	92	1	our	our	PRON
bam-1791	92	2	results	result	NOUN
bam-1791	92	3	indicate	indicate	VERB
bam-1791	92	4	that	that	SCONJ
bam-1791	92	5	oxygen	oxygen	NOUN
bam-1791	92	6	content	content	NOUN
bam-1791	92	7	regulates	regulate	VERB
bam-1791	92	8	mirna	mirna	NOUN
bam-1791	92	9	expression	expression	NOUN
bam-1791	92	10	,	,	PUNCT
bam-1791	92	11	and	and	CCONJ
bam-1791	92	12	thus	thus	ADV
bam-1791	92	13	modulates	modulate	VERB
bam-1791	92	14	satellite	satellite	NOUN
bam-1791	92	15	cell	cell	NOUN
bam-1791	92	16	proliferation	proliferation	NOUN
bam-1791	92	17	and	and	CCONJ
bam-1791	92	18	differentiation	differentiation	NOUN
bam-1791	92	19	.	.	PUNCT
bam-1791	93	1	this	this	DET
bam-1791	93	2	phenomenon	phenomenon	NOUN
bam-1791	93	3	could	could	AUX
bam-1791	93	4	explain	explain	VERB
bam-1791	93	5	,	,	PUNCT
bam-1791	93	6	at	at	ADP
bam-1791	93	7	least	least	ADJ
bam-1791	93	8	in	in	ADP
bam-1791	93	9	part	part	NOUN
bam-1791	93	10	,	,	PUNCT
bam-1791	93	11	the	the	DET
bam-1791	93	12	myogenic	myogenic	ADJ
bam-1791	93	13	potential	potential	ADJ
bam-1791	93	14	impairment	impairment	NOUN
bam-1791	93	15	observed	observe	VERB
bam-1791	93	16	in	in	ADP
bam-1791	93	17	satellite	satellite	NOUN
bam-1791	93	18	cells	cell	NOUN
bam-1791	93	19	isolated	isolate	VERB
bam-1791	93	20	from	from	ADP
bam-1791	93	21	climbers	climber	NOUN
bam-1791	93	22	after	after	ADP
bam-1791	93	23	prolonged	prolonged	ADJ
bam-1791	93	24	exposure	exposure	NOUN
bam-1791	93	25	to	to	ADP
bam-1791	93	26	extreme	extreme	ADJ
bam-1791	93	27	altitude	altitude	NOUN
bam-1791	93	28	(	(	PUNCT
bam-1791	93	29	mancinelli	mancinelli	X
bam-1791	93	30	et	et	PROPN
bam-1791	93	31	al	al	PROPN
bam-1791	93	32	2011	2011	NUM
bam-1791	93	33	)	)	PUNCT
bam-1791	93	34	.	.	PUNCT
bam-1791	94	1	8	8	X
bam-1791	94	2	.	.	PUNCT
bam-1791	95	1	mef2c	mef2c	NOUN
bam-1791	95	2	phosphorylation	phosphorylation	NOUN
bam-1791	95	3	:	:	PUNCT
bam-1791	95	4	a	a	DET
bam-1791	95	5	regulatory	regulatory	ADJ
bam-1791	95	6	mechanism	mechanism	NOUN
bam-1791	95	7	in	in	ADP
bam-1791	95	8	satellite	satellite	NOUN
bam-1791	95	9	cells	cell	NOUN
bam-1791	95	10	baruffaldi	baruffaldi	NOUN
bam-1791	95	11	f.1	f.1	NOUN
bam-1791	95	12	,	,	PUNCT
bam-1791	95	13	ganassi	ganassi	PROPN
bam-1791	95	14	m.	m.	NOUN
bam-1791	95	15	1	1	NUM
bam-1791	95	16	,	,	PUNCT
bam-1791	95	17	badodi	badodi	NOUN
bam-1791	95	18	s.	s.	PROPN
bam-1791	95	19	1	1	NUM
bam-1791	95	20	,	,	PUNCT
bam-1791	95	21	buckingham	buckingham	PROPN
bam-1791	95	22	m.2	m.2	NOUN
bam-1791	95	23	,	,	PUNCT
bam-1791	95	24	montarras	montarras	PROPN
bam-1791	95	25	d.	d.	PROPN
bam-1791	95	26	2	2	NUM
bam-1791	95	27	,	,	PUNCT
bam-1791	95	28	molinari	molinari	PROPN
bam-1791	95	29	s.	s.	PROPN
bam-1791	95	30	1	1	NUM
bam-1791	95	31	(	(	PUNCT
bam-1791	95	32	1	1	NUM
bam-1791	95	33	)	)	PUNCT
bam-1791	95	34	department	department	NOUN
bam-1791	95	35	of	of	ADP
bam-1791	95	36	life	life	NOUN
bam-1791	95	37	sciences	sciences	PROPN
bam-1791	95	38	,	,	PUNCT
bam-1791	95	39	university	university	NOUN
bam-1791	95	40	of	of	ADP
bam-1791	95	41	modena	modena	PROPN
bam-1791	95	42	and	and	CCONJ
bam-1791	95	43	reggio	reggio	PROPN
bam-1791	95	44	emilia	emilia	PROPN
bam-1791	95	45	,	,	PUNCT
bam-1791	95	46	modena	modena	PROPN
bam-1791	95	47	,	,	PUNCT
bam-1791	95	48	italy	italy	PROPN
bam-1791	95	49	;	;	PUNCT
bam-1791	95	50	(	(	PUNCT
bam-1791	95	51	2	2	X
bam-1791	95	52	)	)	PUNCT
bam-1791	95	53	unité	unité	PROPN
bam-1791	95	54	de	de	X
bam-1791	95	55	génétique	génétique	PROPN
bam-1791	95	56	moléculaire	moléculaire	PROPN
bam-1791	95	57	du	du	PROPN
bam-1791	95	58	développement	développement	PROPN
bam-1791	95	59	institut	institut	PROPN
bam-1791	95	60	pasteur	pasteur	PROPN
bam-1791	95	61	,	,	PUNCT
bam-1791	95	62	paris	paris	PROPN
bam-1791	95	63	,	,	PUNCT
bam-1791	95	64	france	france	PROPN
bam-1791	95	65	mef2c	mef2c	PROPN
bam-1791	95	66	belongs	belong	VERB
bam-1791	95	67	to	to	ADP
bam-1791	95	68	the	the	DET
bam-1791	95	69	family	family	NOUN
bam-1791	95	70	of	of	ADP
bam-1791	95	71	myocyte	myocyte	PROPN
bam-1791	95	72	enhancer	enhancer	NOUN
bam-1791	95	73	factor	factor	NOUN
bam-1791	95	74	2	2	NUM
bam-1791	96	1	transcription	transcription	NOUN
bam-1791	96	2	factors	factor	NOUN
bam-1791	96	3	,	,	PUNCT
bam-1791	96	4	which	which	PRON
bam-1791	96	5	activate	activate	VERB
bam-1791	96	6	the	the	DET
bam-1791	96	7	muscle	muscle	NOUN
bam-1791	96	8	-	-	PUNCT
bam-1791	96	9	specific	specific	ADJ
bam-1791	96	10	gene	gene	NOUN
bam-1791	96	11	expression	expression	NOUN
bam-1791	96	12	program	program	NOUN
bam-1791	96	13	synergistically	synergistically	ADV
bam-1791	96	14	with	with	ADP
bam-1791	96	15	the	the	DET
bam-1791	96	16	bhlh	bhlh	NOUN
bam-1791	96	17	muscle	muscle	VERB
bam-1791	96	18	regulatory	regulatory	ADJ
bam-1791	96	19	factors	factor	NOUN
bam-1791	96	20	.	.	PUNCT
bam-1791	97	1	in	in	ADP
bam-1791	97	2	skeletal	skeletal	ADJ
bam-1791	97	3	muscle	muscle	NOUN
bam-1791	97	4	cells	cell	NOUN
bam-1791	97	5	mef2c	mef2c	PUNCT
bam-1791	97	6	is	be	AUX
bam-1791	97	7	expressed	express	VERB
bam-1791	97	8	already	already	ADV
bam-1791	97	9	at	at	ADP
bam-1791	97	10	the	the	DET
bam-1791	97	11	proliferating	proliferate	VERB
bam-1791	97	12	stage	stage	NOUN
bam-1791	97	13	,	,	PUNCT
bam-1791	97	14	but	but	CCONJ
bam-1791	97	15	its	its	PRON
bam-1791	97	16	transcriptional	transcriptional	ADJ
bam-1791	97	17	activity	activity	NOUN
bam-1791	97	18	is	be	AUX
bam-1791	97	19	silent	silent	ADJ
bam-1791	97	20	,	,	PUNCT
bam-1791	97	21	highlighting	highlight	VERB
bam-1791	97	22	that	that	SCONJ
bam-1791	97	23	its	its	PRON
bam-1791	97	24	function	function	NOUN
bam-1791	97	25	is	be	AUX
bam-1791	97	26	finely	finely	ADV
bam-1791	97	27	regulated	regulate	VERB
bam-1791	97	28	at	at	ADP
bam-1791	97	29	several	several	ADJ
bam-1791	97	30	levels	level	NOUN
bam-1791	97	31	,	,	PUNCT
bam-1791	97	32	including	include	VERB
bam-1791	97	33	alternative	alternative	ADJ
bam-1791	97	34	splicing	splicing	NOUN
bam-1791	97	35	patterns	pattern	NOUN
bam-1791	97	36	,	,	PUNCT
bam-1791	97	37	post	post	ADJ
bam-1791	97	38	-	-	ADJ
bam-1791	97	39	translational	translational	ADJ
bam-1791	97	40	modifications	modification	NOUN
bam-1791	97	41	and	and	CCONJ
bam-1791	97	42	proteinprotein	proteinprotein	ADJ
bam-1791	97	43	interactions	interaction	NOUN
bam-1791	97	44	with	with	ADP
bam-1791	97	45	regulators	regulator	NOUN
bam-1791	97	46	.	.	PUNCT
bam-1791	98	1	several	several	ADJ
bam-1791	98	2	studies	study	NOUN
bam-1791	98	3	showed	show	VERB
bam-1791	98	4	that	that	DET
bam-1791	98	5	phosphorylation	phosphorylation	NOUN
bam-1791	98	6	of	of	ADP
bam-1791	98	7	mef2	mef2	ADJ
bam-1791	98	8	factors	factor	NOUN
bam-1791	98	9	at	at	ADP
bam-1791	98	10	so	so	ADV
bam-1791	98	11	-	-	PUNCT
bam-1791	98	12	called	call	VERB
bam-1791	98	13	ser	ser	NOUN
bam-1791	98	14	/	/	SYM
bam-1791	98	15	thrpro	thrpro	ADJ
bam-1791	98	16	motifs	motif	NOUN
bam-1791	98	17	can	can	AUX
bam-1791	98	18	modulate	modulate	VERB
bam-1791	98	19	protein	protein	NOUN
bam-1791	98	20	function	function	NOUN
bam-1791	98	21	through	through	ADP
bam-1791	98	22	the	the	DET
bam-1791	98	23	induction	induction	NOUN
bam-1791	98	24	of	of	ADP
bam-1791	98	25	conformational	conformational	ADJ
bam-1791	98	26	changes	change	NOUN
bam-1791	98	27	by	by	ADP
bam-1791	98	28	the	the	DET
bam-1791	98	29	peptidyl	peptidyl	NOUN
bam-1791	98	30	–	–	PUNCT
bam-1791	98	31	prolyl	prolyl	ADJ
bam-1791	98	32	cis	cis	PROPN
bam-1791	98	33	/	/	SYM
bam-1791	98	34	trans	trans	X
bam-1791	98	35	isomerase	isomerase	ADJ
bam-1791	98	36	pin1	pin1	NOUN
bam-1791	98	37	.	.	PUNCT
bam-1791	99	1	we	we	PRON
bam-1791	99	2	identified	identify	VERB
bam-1791	99	3	two	two	NUM
bam-1791	99	4	novel	novel	ADJ
bam-1791	99	5	critical	critical	ADJ
bam-1791	99	6	phosphorylation	phosphorylation	NOUN
bam-1791	99	7	sites	site	NOUN
bam-1791	99	8	in	in	ADP
bam-1791	99	9	mef2c	mef2c	PROPN
bam-1791	99	10	,	,	PUNCT
bam-1791	99	11	ser98	ser98	PROPN
bam-1791	99	12	and	and	CCONJ
bam-1791	99	13	ser110	ser110	PROPN
bam-1791	99	14	,	,	PUNCT
bam-1791	99	15	located	locate	VERB
bam-1791	99	16	in	in	ADP
bam-1791	99	17	the	the	DET
bam-1791	99	18	alternative	alternative	ADJ
bam-1791	99	19	spliced	splice	VERB
bam-1791	99	20	exon	exon	ADJ
bam-1791	99	21	α1	α1	PROPN
bam-1791	99	22	and	and	CCONJ
bam-1791	99	23	essential	essential	ADJ
bam-1791	99	24	for	for	ADP
bam-1791	99	25	the	the	DET
bam-1791	99	26	binding	binding	NOUN
bam-1791	99	27	with	with	ADP
bam-1791	99	28	the	the	DET
bam-1791	99	29	negative	negative	ADJ
bam-1791	99	30	regulator	regulator	NOUN
bam-1791	99	31	pin1	pin1	NOUN
bam-1791	99	32	.	.	PUNCT
bam-1791	100	1	using	use	VERB
bam-1791	100	2	two	two	NUM
bam-1791	100	3	polyclonal	polyclonal	ADJ
bam-1791	100	4	phosphor	phosphor	NOUN
bam-1791	100	5	-	-	PUNCT
bam-1791	100	6	specific	specific	ADJ
bam-1791	100	7	antibodies	antibody	NOUN
bam-1791	100	8	,	,	PUNCT
bam-1791	100	9	we	we	PRON
bam-1791	100	10	observed	observe	VERB
bam-1791	100	11	that	that	SCONJ
bam-1791	100	12	the	the	DET
bam-1791	100	13	phosphorylation	phosphorylation	NOUN
bam-1791	100	14	of	of	ADP
bam-1791	100	15	ser98	ser98	PROPN
bam-1791	100	16	and	and	CCONJ
bam-1791	100	17	ser110	ser110	PROPN
bam-1791	100	18	,	,	PUNCT
bam-1791	100	19	which	which	PRON
bam-1791	100	20	negatively	negatively	ADV
bam-1791	100	21	affects	affect	VERB
bam-1791	100	22	mef2c	mef2c	NOUN
bam-1791	100	23	function	function	NOUN
bam-1791	100	24	,	,	PUNCT
bam-1791	100	25	decreases	decrease	VERB
bam-1791	100	26	upon	upon	SCONJ
bam-1791	100	27	induction	induction	NOUN
bam-1791	100	28	of	of	ADP
bam-1791	100	29	muscle	muscle	NOUN
bam-1791	100	30	differentiation	differentiation	NOUN
bam-1791	100	31	,	,	PUNCT
bam-1791	100	32	coherently	coherently	ADV
bam-1791	100	33	with	with	ADP
bam-1791	100	34	the	the	DET
bam-1791	100	35	hypothesis	hypothesis	NOUN
bam-1791	100	36	of	of	ADP
bam-1791	100	37	phosphorylation	phosphorylation	NOUN
bam-1791	100	38	-	-	PUNCT
bam-1791	100	39	based	base	VERB
bam-1791	100	40	negative	negative	ADJ
bam-1791	100	41	regulation	regulation	NOUN
bam-1791	100	42	of	of	ADP
bam-1791	100	43	mef2c	mef2c	PROPN
bam-1791	100	44	.	.	PUNCT
bam-1791	101	1	we	we	PRON
bam-1791	101	2	confirmed	confirm	VERB
bam-1791	101	3	the	the	DET
bam-1791	101	4	same	same	ADJ
bam-1791	101	5	regulatory	regulatory	ADJ
bam-1791	101	6	mechanism	mechanism	NOUN
bam-1791	101	7	also	also	ADV
bam-1791	101	8	in	in	ADP
bam-1791	101	9	primary	primary	ADJ
bam-1791	101	10	myogenic	myogenic	ADJ
bam-1791	101	11	stem	stem	NOUN
bam-1791	101	12	cells	cell	NOUN
bam-1791	101	13	(	(	PUNCT
bam-1791	101	14	scs	scs	PROPN
bam-1791	101	15	)	)	PUNCT
bam-1791	101	16	by	by	ADP
bam-1791	101	17	the	the	DET
bam-1791	101	18	combined	combine	VERB
bam-1791	101	19	analysis	analysis	NOUN
bam-1791	101	20	of	of	ADP
bam-1791	101	21	the	the	DET
bam-1791	101	22	dynamic	dynamic	NOUN
bam-1791	101	23	of	of	ADP
bam-1791	101	24	mef2c	mef2c	PROPN
bam-1791	101	25	phosphorylation	phosphorylation	NOUN
bam-1791	101	26	with	with	ADP
bam-1791	101	27	the	the	DET
bam-1791	101	28	study	study	NOUN
bam-1791	101	29	of	of	ADP
bam-1791	101	30	the	the	DET
bam-1791	101	31	alternative	alternative	ADJ
bam-1791	101	32	splicing	splicing	NOUN
bam-1791	101	33	pattern	pattern	NOUN
bam-1791	101	34	in	in	ADP
bam-1791	101	35	satellite	satellite	NOUN
bam-1791	101	36	cells	cell	NOUN
bam-1791	101	37	retained	retain	VERB
bam-1791	101	38	in	in	ADP
bam-1791	101	39	their	their	PRON
bam-1791	101	40	niche	niche	NOUN
bam-1791	101	41	associated	associate	VERB
bam-1791	101	42	with	with	ADP
bam-1791	101	43	isolated	isolated	ADJ
bam-1791	101	44	myofibers	myofiber	NOUN
bam-1791	101	45	.	.	PUNCT
bam-1791	102	1	taken	take	VERB
bam-1791	102	2	together	together	ADV
bam-1791	102	3	our	our	PRON
bam-1791	102	4	results	result	NOUN
bam-1791	102	5	lead	lead	VERB
bam-1791	102	6	us	we	PRON
bam-1791	102	7	to	to	PART
bam-1791	102	8	suppose	suppose	VERB
bam-1791	102	9	that	that	SCONJ
bam-1791	102	10	mef2c	mef2c	NOUN
bam-1791	102	11	phosphorylation	phosphorylation	NOUN
bam-1791	102	12	on	on	ADP
bam-1791	102	13	the	the	DET
bam-1791	102	14	pin1	pin1	NOUN
bam-1791	102	15	binding	bind	VERB
bam-1791	102	16	sites	site	NOUN
bam-1791	102	17	and	and	CCONJ
bam-1791	102	18	the	the	DET
bam-1791	102	19	consequent	consequent	ADJ
bam-1791	102	20	interaction	interaction	NOUN
bam-1791	102	21	with	with	ADP
bam-1791	102	22	pin1	pin1	NOUN
bam-1791	102	23	might	might	AUX
bam-1791	102	24	contribute	contribute	VERB
bam-1791	102	25	to	to	PART
bam-1791	102	26	keep	keep	VERB
bam-1791	102	27	silent	silent	ADJ
bam-1791	102	28	the	the	DET
bam-1791	102	29	mef2c	mef2c	NOUN
bam-1791	102	30	-	-	PUNCT
bam-1791	102	31	dependent	dependent	ADJ
bam-1791	102	32	transcription	transcription	NOUN
bam-1791	102	33	of	of	ADP
bam-1791	102	34	muscle	muscle	NOUN
bam-1791	102	35	specific	specific	ADJ
bam-1791	102	36	genes	gene	NOUN
bam-1791	102	37	in	in	ADP
bam-1791	102	38	proliferating	proliferate	VERB
bam-1791	102	39	scs	sc	NOUN
bam-1791	102	40	avoiding	avoid	VERB
bam-1791	102	41	their	their	PRON
bam-1791	102	42	premature	premature	ADJ
bam-1791	102	43	differentiation	differentiation	NOUN
bam-1791	102	44	and	and	CCONJ
bam-1791	102	45	allowing	allow	VERB
bam-1791	102	46	the	the	DET
bam-1791	102	47	expansion	expansion	NOUN
bam-1791	102	48	of	of	ADP
bam-1791	102	49	the	the	DET
bam-1791	102	50	activated	activate	VERB
bam-1791	102	51	scs	scs	NOUN
bam-1791	102	52	pool	pool	NOUN
bam-1791	102	53	.	.	PUNCT
bam-1791	103	1	9	9	X
bam-1791	103	2	.	.	X
bam-1791	103	3	regulation	regulation	NOUN
bam-1791	103	4	of	of	ADP
bam-1791	103	5	satellite	satellite	NOUN
bam-1791	103	6	cell	cell	NOUN
bam-1791	103	7	function	function	NOUN
bam-1791	103	8	by	by	ADP
bam-1791	103	9	cylin	cylin	PROPN
bam-1791	103	10	d3	d3	PROPN
bam-1791	103	11	giulia	giulia	PROPN
bam-1791	103	12	de	de	X
bam-1791	103	13	luca	luca	PROPN
bam-1791	103	14	,	,	PUNCT
bam-1791	103	15	roberta	roberta	PROPN
bam-1791	103	16	ferretti	ferretti	PROPN
bam-1791	103	17	,	,	PUNCT
bam-1791	103	18	marco	marco	PROPN
bam-1791	103	19	bruschi	bruschi	PROPN
bam-1791	103	20	,	,	PUNCT
bam-1791	103	21	eleonora	eleonora	PROPN
bam-1791	103	22	mezzaroma	mezzaroma	PROPN
bam-1791	103	23	,	,	PUNCT
bam-1791	103	24	maurizia	maurizia	PROPN
bam-1791	103	25	caruso	caruso	PROPN
bam-1791	103	26	cnrinstituto	cnrinstituto	PROPN
bam-1791	103	27	di	di	PROPN
bam-1791	103	28	biologia	biologia	PROPN
bam-1791	103	29	cellulare	cellulare	PROPN
bam-1791	103	30	e	e	PROPN
bam-1791	103	31	neurobiologia	neurobiologia	NOUN
bam-1791	103	32	in	in	ADP
bam-1791	103	33	regenerating	regenerate	VERB
bam-1791	103	34	adult	adult	NOUN
bam-1791	103	35	skeletal	skeletal	ADJ
bam-1791	103	36	muscle	muscle	NOUN
bam-1791	103	37	,	,	PUNCT
bam-1791	103	38	the	the	DET
bam-1791	103	39	function	function	NOUN
bam-1791	103	40	of	of	ADP
bam-1791	103	41	myod	myod	PROPN
bam-1791	103	42	is	be	AUX
bam-1791	103	43	critically	critically	ADV
bam-1791	103	44	required	require	VERB
bam-1791	103	45	to	to	PART
bam-1791	103	46	coordinate	coordinate	VERB
bam-1791	103	47	cell	cell	NOUN
bam-1791	103	48	cycle	cycle	NOUN
bam-1791	103	49	kinetics	kinetic	NOUN
bam-1791	103	50	and	and	CCONJ
bam-1791	103	51	terminal	terminal	ADJ
bam-1791	103	52	differentiation	differentiation	NOUN
bam-1791	103	53	of	of	ADP
bam-1791	103	54	myogenic	myogenic	ADJ
bam-1791	103	55	progenitor	progenitor	NOUN
bam-1791	103	56	cells	cell	NOUN
bam-1791	103	57	.	.	PUNCT
bam-1791	104	1	in	in	ADP
bam-1791	104	2	previous	previous	ADJ
bam-1791	104	3	studies	study	NOUN
bam-1791	104	4	we	we	PRON
bam-1791	104	5	and	and	CCONJ
bam-1791	104	6	others	other	NOUN
bam-1791	104	7	have	have	AUX
bam-1791	104	8	shown	show	VERB
bam-1791	104	9	that	that	SCONJ
bam-1791	104	10	myod	myod	VERB
bam-1791	104	11	couples	couple	NOUN
bam-1791	104	12	the	the	DET
bam-1791	104	13	onset	onset	NOUN
bam-1791	104	14	of	of	ADP
bam-1791	104	15	differentiation	differentiation	NOUN
bam-1791	104	16	with	with	ADP
bam-1791	104	17	cell	cell	NOUN
bam-1791	104	18	-	-	PUNCT
bam-1791	104	19	cycle	cycle	NOUN
bam-1791	104	20	arrest	arrest	NOUN
bam-1791	104	21	by	by	ADP
bam-1791	104	22	inducing	induce	VERB
bam-1791	104	23	the	the	DET
bam-1791	104	24	cell	cell	NOUN
bam-1791	104	25	-	-	PUNCT
bam-1791	104	26	cycle	cycle	NOUN
bam-1791	104	27	inhibitors	inhibitor	NOUN
bam-1791	104	28	prb	prb	NOUN
bam-1791	104	29	and	and	CCONJ
bam-1791	104	30	p21	p21	NOUN
bam-1791	104	31	.	.	PUNCT
bam-1791	105	1	however	however	ADV
bam-1791	105	2	,	,	PUNCT
bam-1791	105	3	myod	myod	PROPN
bam-1791	105	4	also	also	ADV
bam-1791	105	5	appears	appear	VERB
bam-1791	105	6	to	to	PART
bam-1791	105	7	induce	induce	VERB
bam-1791	105	8	the	the	DET
bam-1791	105	9	expression	expression	NOUN
bam-1791	105	10	of	of	ADP
bam-1791	105	11	factors	factor	NOUN
bam-1791	105	12	deputed	depute	VERB
bam-1791	105	13	to	to	PART
bam-1791	105	14	promote	promote	VERB
bam-1791	105	15	cell	cell	NOUN
bam-1791	105	16	division	division	NOUN
bam-1791	105	17	,	,	PUNCT
bam-1791	105	18	such	such	ADJ
bam-1791	105	19	as	as	ADP
bam-1791	105	20	cdc6	cdc6	PROPN
bam-1791	105	21	and	and	CCONJ
bam-1791	105	22	cyclin	cyclin	PROPN
bam-1791	105	23	d3	d3	PROPN
bam-1791	105	24	.	.	PUNCT
bam-1791	106	1	to	to	PART
bam-1791	106	2	start	start	VERB
bam-1791	106	3	investigating	investigate	VERB
bam-1791	106	4	the	the	DET
bam-1791	106	5	role	role	NOUN
bam-1791	106	6	of	of	ADP
bam-1791	106	7	cyclin	cyclin	NOUN
bam-1791	106	8	d3	d3	PROPN
bam-1791	106	9	in	in	ADP
bam-1791	106	10	the	the	DET
bam-1791	106	11	control	control	NOUN
bam-1791	106	12	of	of	ADP
bam-1791	106	13	muscle	muscle	NOUN
bam-1791	106	14	progenitor	progenitor	NOUN
bam-1791	106	15	cell	cell	NOUN
bam-1791	106	16	function	function	NOUN
bam-1791	106	17	,	,	PUNCT
bam-1791	106	18	we	we	PRON
bam-1791	106	19	used	use	VERB
bam-1791	106	20	rnai	rnai	PROPN
bam-1791	106	21	technology	technology	PROPN
bam-1791	106	22	to	to	PART
bam-1791	106	23	knockdown	knockdown	VERB
bam-1791	106	24	cyclin	cyclin	NOUN
bam-1791	106	25	d3	d3	PROPN
bam-1791	106	26	protein	protein	NOUN
bam-1791	106	27	levels	level	NOUN
bam-1791	106	28	in	in	ADP
bam-1791	106	29	c2	c2	PROPN
bam-1791	106	30	myoblasts	myoblast	NOUN
bam-1791	106	31	,	,	PUNCT
bam-1791	106	32	which	which	PRON
bam-1791	106	33	resulted	result	VERB
bam-1791	106	34	in	in	ADP
bam-1791	106	35	reduced	reduced	ADJ
bam-1791	106	36	proliferation	proliferation	NOUN
bam-1791	106	37	,	,	PUNCT
bam-1791	106	38	premature	premature	ADJ
bam-1791	106	39	expression	expression	NOUN
bam-1791	106	40	of	of	ADP
bam-1791	106	41	differentiation	differentiation	NOUN
bam-1791	106	42	markers	marker	NOUN
bam-1791	106	43	and	and	CCONJ
bam-1791	106	44	impaired	impaired	ADJ
bam-1791	106	45	myotube	myotube	NOUN
bam-1791	106	46	formation	formation	NOUN
bam-1791	106	47	.	.	PUNCT
bam-1791	107	1	this	this	PRON
bam-1791	107	2	suggested	suggest	VERB
bam-1791	107	3	that	that	SCONJ
bam-1791	107	4	cyclin	cyclin	PROPN
bam-1791	107	5	d3	d3	PROPN
bam-1791	107	6	controls	control	VERB
bam-1791	107	7	the	the	DET
bam-1791	107	8	balance	balance	NOUN
bam-1791	107	9	between	between	ADP
bam-1791	107	10	myoblast	myoblast	ADJ
bam-1791	107	11	proliferation	proliferation	NOUN
bam-1791	107	12	and	and	CCONJ
bam-1791	107	13	differentiation	differentiation	NOUN
bam-1791	107	14	.	.	PUNCT
bam-1791	108	1	to	to	PART
bam-1791	108	2	assess	assess	VERB
bam-1791	108	3	the	the	DET
bam-1791	108	4	role	role	NOUN
bam-1791	108	5	played	play	VERB
bam-1791	108	6	by	by	ADP
bam-1791	108	7	cyclin	cyclin	PROPN
bam-1791	108	8	d3	d3	PROPN
bam-1791	108	9	in	in	ADP
bam-1791	108	10	skeletal	skeletal	ADJ
bam-1791	108	11	muscle	muscle	NOUN
bam-1791	108	12	in	in	ADP
bam-1791	108	13	vivo	vivo	NOUN
bam-1791	108	14	,	,	PUNCT
bam-1791	108	15	we	we	PRON
bam-1791	108	16	exploited	exploit	VERB
bam-1791	108	17	cyclin	cyclin	PROPN
bam-1791	108	18	d3	d3	PROPN
bam-1791	108	19	knockout	knockout	PROPN
bam-1791	108	20	mice	mouse	NOUN
bam-1791	108	21	.	.	PUNCT
bam-1791	109	1	cyclin	cyclin	PROPN
bam-1791	109	2	d3	d3	PROPN
bam-1791	109	3	-	-	PUNCT
bam-1791	109	4	null	null	NOUN
bam-1791	109	5	tibialis	tibialis	NOUN
bam-1791	109	6	muscles	muscle	NOUN
bam-1791	109	7	collected	collect	VERB
bam-1791	109	8	from	from	ADP
bam-1791	109	9	2	2	NUM
bam-1791	109	10	-	-	PUNCT
bam-1791	109	11	mo	mo	ADJ
bam-1791	109	12	-	-	ADJ
bam-1791	109	13	old	old	ADJ
bam-1791	109	14	mice	mouse	NOUN
bam-1791	109	15	showed	show	VERB
bam-1791	109	16	fewer	few	ADJ
bam-1791	109	17	satellite	satellite	NOUN
bam-1791	109	18	cells	cell	NOUN
bam-1791	109	19	and	and	CCONJ
bam-1791	109	20	a	a	DET
bam-1791	109	21	decrease	decrease	NOUN
bam-1791	109	22	in	in	ADP
bam-1791	109	23	myofiber	myofiber	ADJ
bam-1791	109	24	size	size	NOUN
bam-1791	109	25	when	when	SCONJ
bam-1791	109	26	compared	compare	VERB
bam-1791	109	27	with	with	ADP
bam-1791	109	28	wild	wild	ADJ
bam-1791	109	29	-	-	PUNCT
bam-1791	109	30	type	type	NOUN
bam-1791	109	31	controls	control	NOUN
bam-1791	109	32	.	.	PUNCT
bam-1791	110	1	the	the	DET
bam-1791	110	2	analysis	analysis	NOUN
bam-1791	110	3	of	of	ADP
bam-1791	110	4	primary	primary	ADJ
bam-1791	110	5	myoblast	myoblast	ADJ
bam-1791	110	6	cultures	culture	NOUN
bam-1791	110	7	and	and	CCONJ
bam-1791	110	8	of	of	ADP
bam-1791	110	9	satellite	satellite	NOUN
bam-1791	110	10	cells	cell	NOUN
bam-1791	110	11	activated	activate	VERB
bam-1791	110	12	in	in	ADP
bam-1791	110	13	vivo	vivo	NOUN
bam-1791	110	14	following	follow	VERB
bam-1791	110	15	muscle	muscle	NOUN
bam-1791	110	16	injury	injury	NOUN
bam-1791	110	17	revealed	reveal	VERB
bam-1791	110	18	cyclin	cyclin	PROPN
bam-1791	110	19	d3	d3	PROPN
bam-1791	110	20	is	be	AUX
bam-1791	110	21	critically	critically	ADV
bam-1791	110	22	required	require	VERB
bam-1791	110	23	for	for	ADP
bam-1791	110	24	proliferative	proliferative	ADJ
bam-1791	110	25	expansion	expansion	NOUN
bam-1791	110	26	of	of	ADP
bam-1791	110	27	myogenic	myogenic	ADJ
bam-1791	110	28	precursor	precursor	NOUN
bam-1791	110	29	cells	cell	NOUN
bam-1791	110	30	.	.	PUNCT
bam-1791	111	1	finally	finally	ADV
bam-1791	111	2	,	,	PUNCT
bam-1791	111	3	the	the	DET
bam-1791	111	4	analysis	analysis	NOUN
bam-1791	111	5	of	of	ADP
bam-1791	111	6	satellite	satellite	NOUN
bam-1791	111	7	cells	cell	NOUN
bam-1791	111	8	associated	associate	VERB
bam-1791	111	9	to	to	ADP
bam-1791	111	10	single	single	ADJ
bam-1791	111	11	fibers	fiber	NOUN
bam-1791	111	12	indicated	indicate	VERB
bam-1791	111	13	that	that	SCONJ
bam-1791	111	14	cyclind3	cyclind3	NOUN
bam-1791	111	15	-	-	PUNCT
bam-1791	111	16	null	null	ADJ
bam-1791	111	17	myogenic	myogenic	ADJ
bam-1791	111	18	progenitors	progenitor	NOUN
bam-1791	111	19	have	have	VERB
bam-1791	111	20	a	a	DET
bam-1791	111	21	higher	high	ADJ
bam-1791	111	22	propensity	propensity	NOUN
bam-1791	111	23	to	to	PART
bam-1791	111	24	differentiate	differentiate	VERB
bam-1791	111	25	and	and	CCONJ
bam-1791	111	26	a	a	DET
bam-1791	111	27	reduced	reduce	VERB
bam-1791	111	28	ability	ability	NOUN
bam-1791	111	29	to	to	PART
bam-1791	111	30	generate	generate	VERB
bam-1791	111	31	undifferentiated	undifferentiated	ADJ
bam-1791	111	32	reserve	reserve	NOUN
bam-1791	111	33	cells	cell	NOUN
bam-1791	111	34	.	.	PUNCT
bam-1791	112	1	ix	ix	PROPN
bam-1791	112	2	iim	iim	PROPN
bam-1791	112	3	meeting	meeting	NOUN
bam-1791	112	4	,	,	PUNCT
bam-1791	112	5	acaya	acaya	NOUN
bam-1791	112	6	(	(	PUNCT
bam-1791	112	7	lecce	lecce	PROPN
bam-1791	112	8	)	)	PUNCT
bam-1791	112	9	,	,	PUNCT
bam-1791	112	10	october	october	PROPN
bam-1791	112	11	12	12	NUM
bam-1791	112	12	-	-	SYM
bam-1791	112	13	14	14	NUM
bam-1791	112	14	,	,	PUNCT
bam-1791	112	15	2012	2012	NUM
bam-1791	112	16	european	european	PROPN
bam-1791	112	17	journal	journal	PROPN
bam-1791	112	18	translational	translational	ADJ
bam-1791	112	19	myology	myology	NOUN
bam-1791	112	20	basic	basic	ADJ
bam-1791	112	21	applied	apply	VERB
bam-1791	112	22	myology	myology	NOUN
bam-1791	112	23	2012	2012	NUM
bam-1791	112	24	;	;	PUNCT
bam-1791	112	25	22(1&2	22(1&2	NUM
bam-1791	112	26	):	):	PUNCT
bam-1791	112	27	xxx	xxx	NOUN
bam-1791	112	28	-	-	PUNCT
bam-1791	112	29	xxx	xxx	NOUN
bam-1791	112	30	24	24	NUM
bam-1791	112	31	10	10	NUM
bam-1791	112	32	.	.	PUNCT
bam-1791	113	1	the	the	DET
bam-1791	113	2	transcription	transcription	NOUN
bam-1791	113	3	factor	factor	NOUN
bam-1791	113	4	snai1	snai1	NOUN
bam-1791	113	5	regulates	regulate	VERB
bam-1791	113	6	myoblasts	myoblast	NOUN
bam-1791	113	7	proliferation	proliferation	NOUN
bam-1791	113	8	and	and	CCONJ
bam-1791	113	9	neovascularization	neovascularization	NOUN
bam-1791	113	10	during	during	ADP
bam-1791	113	11	muscle	muscle	NOUN
bam-1791	113	12	regeneration	regeneration	NOUN
bam-1791	113	13	.	.	PUNCT
bam-1791	114	1	di	di	PROPN
bam-1791	114	2	mauro	mauro	PROPN
bam-1791	114	3	v.1	v.1	PUNCT
bam-1791	114	4	,	,	PUNCT
bam-1791	114	5	borghi	borghi	PROPN
bam-1791	114	6	s.1	s.1	PROPN
bam-1791	114	7	,	,	PUNCT
bam-1791	114	8	vitiello	vitiello	PROPN
bam-1791	114	9	l.2	l.2	NOUN
bam-1791	114	10	,	,	PUNCT
bam-1791	114	11	galletta	galletta	ADJ
bam-1791	114	12	e.2	e.2	NOUN
bam-1791	114	13	,	,	PUNCT
bam-1791	114	14	anselmi	anselmi	ADJ
bam-1791	114	15	f.1	f.1	NOUN
bam-1791	114	16	,	,	PUNCT
bam-1791	114	17	orlandini	orlandini	ADJ
bam-1791	114	18	m.1	m.1	PROPN
bam-1791	114	19	,	,	PUNCT
bam-1791	114	20	oliviero	oliviero	VERB
bam-1791	114	21	s.1	s.1	NOUN
bam-1791	114	22	,	,	PUNCT
bam-1791	114	23	galvagni	galvagni	NOUN
bam-1791	114	24	f.1	f.1	NOUN
bam-1791	114	25	1	1	NUM
bam-1791	114	26	department	department	NOUN
bam-1791	114	27	of	of	ADP
bam-1791	114	28	biotechnology	biotechnology	NOUN
bam-1791	114	29	,	,	PUNCT
bam-1791	114	30	university	university	PROPN
bam-1791	114	31	of	of	ADP
bam-1791	114	32	siena	siena	PROPN
bam-1791	114	33	.	.	PROPN
bam-1791	115	1	2	2	NUM
bam-1791	115	2	department	department	NOUN
bam-1791	115	3	of	of	ADP
bam-1791	115	4	biology	biology	NOUN
bam-1791	115	5	,	,	PUNCT
bam-1791	115	6	university	university	NOUN
bam-1791	115	7	of	of	ADP
bam-1791	115	8	padova	padova	PROPN
bam-1791	115	9	.	.	PUNCT
bam-1791	116	1	snai1	snai1	PROPN
bam-1791	116	2	is	be	AUX
bam-1791	116	3	a	a	DET
bam-1791	116	4	zinc	zinc	NOUN
bam-1791	116	5	finger	finger	NOUN
bam-1791	116	6	transcription	transcription	NOUN
bam-1791	116	7	factor	factor	NOUN
bam-1791	116	8	involved	involve	VERB
bam-1791	116	9	in	in	ADP
bam-1791	116	10	a	a	DET
bam-1791	116	11	broad	broad	ADJ
bam-1791	116	12	spectrum	spectrum	NOUN
bam-1791	116	13	of	of	ADP
bam-1791	116	14	biological	biological	ADJ
bam-1791	116	15	functions	function	NOUN
bam-1791	116	16	,	,	PUNCT
bam-1791	116	17	such	such	ADJ
bam-1791	116	18	as	as	ADP
bam-1791	116	19	cell	cell	NOUN
bam-1791	116	20	differentiation	differentiation	NOUN
bam-1791	116	21	,	,	PUNCT
bam-1791	116	22	cell	cell	NOUN
bam-1791	116	23	motility	motility	NOUN
bam-1791	116	24	,	,	PUNCT
bam-1791	116	25	cell	cell	NOUN
bam-1791	116	26	cycle	cycle	NOUN
bam-1791	116	27	regulation	regulation	NOUN
bam-1791	116	28	,	,	PUNCT
bam-1791	116	29	and	and	CCONJ
bam-1791	116	30	apoptosis	apoptosis	NOUN
bam-1791	116	31	.	.	PUNCT
bam-1791	117	1	in	in	ADP
bam-1791	117	2	mouse	mouse	NOUN
bam-1791	117	3	embryo	embryo	NOUN
bam-1791	117	4	snai1	snai1	ADJ
bam-1791	117	5	transcript	transcript	NOUN
bam-1791	117	6	was	be	AUX
bam-1791	117	7	observed	observe	VERB
bam-1791	117	8	in	in	ADP
bam-1791	117	9	the	the	DET
bam-1791	117	10	myotome	myotome	NOUN
bam-1791	117	11	and	and	CCONJ
bam-1791	117	12	sclerotome	sclerotome	NOUN
bam-1791	117	13	as	as	ADV
bam-1791	117	14	well	well	ADV
bam-1791	117	15	as	as	ADP
bam-1791	117	16	in	in	ADP
bam-1791	117	17	the	the	DET
bam-1791	117	18	limb	limb	NOUN
bam-1791	117	19	bud	bud	NOUN
bam-1791	117	20	primordium	primordium	NOUN
bam-1791	117	21	from	from	ADP
bam-1791	117	22	9.5	9.5	NUM
bam-1791	117	23	d.p.c	d.p.c	ADJ
bam-1791	117	24	.	.	PUNCT
bam-1791	118	1	but	but	CCONJ
bam-1791	118	2	the	the	DET
bam-1791	118	3	role	role	NOUN
bam-1791	118	4	that	that	PRON
bam-1791	118	5	snai1	snai1	PROPN
bam-1791	118	6	plays	play	VERB
bam-1791	118	7	in	in	ADP
bam-1791	118	8	the	the	DET
bam-1791	118	9	muscle	muscle	NOUN
bam-1791	118	10	development	development	NOUN
bam-1791	118	11	is	be	AUX
bam-1791	118	12	not	not	PART
bam-1791	118	13	fully	fully	ADV
bam-1791	118	14	understood	understand	VERB
bam-1791	118	15	.	.	PUNCT
bam-1791	119	1	here	here	ADV
bam-1791	119	2	we	we	PRON
bam-1791	119	3	show	show	VERB
bam-1791	119	4	that	that	SCONJ
bam-1791	119	5	snai1	snai1	PROPN
bam-1791	119	6	is	be	AUX
bam-1791	119	7	strongly	strongly	ADV
bam-1791	119	8	upregulated	upregulate	VERB
bam-1791	119	9	during	during	ADP
bam-1791	119	10	muscle	muscle	NOUN
bam-1791	119	11	regeneration	regeneration	NOUN
bam-1791	119	12	and	and	CCONJ
bam-1791	119	13	it	it	PRON
bam-1791	119	14	is	be	AUX
bam-1791	119	15	expressed	express	VERB
bam-1791	119	16	in	in	ADP
bam-1791	119	17	proliferating	proliferate	VERB
bam-1791	119	18	c2c12	c2c12	NOUN
bam-1791	119	19	and	and	CCONJ
bam-1791	119	20	primary	primary	ADJ
bam-1791	119	21	mouse	mouse	NOUN
bam-1791	119	22	myoblasts	myoblast	NOUN
bam-1791	119	23	.	.	PUNCT
bam-1791	120	1	by	by	ADP
bam-1791	120	2	microarray	microarray	NOUN
bam-1791	120	3	analysis	analysis	NOUN
bam-1791	120	4	,	,	PUNCT
bam-1791	120	5	we	we	PRON
bam-1791	120	6	identified	identify	VERB
bam-1791	120	7	64	64	NUM
bam-1791	120	8	genes	gene	NOUN
bam-1791	120	9	up	up	ADV
bam-1791	120	10	-	-	PUNCT
bam-1791	120	11	regulated	regulate	VERB
bam-1791	120	12	and	and	CCONJ
bam-1791	120	13	139	139	NUM
bam-1791	120	14	down	down	ADV
bam-1791	120	15	-	-	PUNCT
bam-1791	120	16	regulated	regulate	VERB
bam-1791	120	17	more	more	ADJ
bam-1791	120	18	than	than	ADP
bam-1791	120	19	3	3	NUM
bam-1791	120	20	fold	fold	NOUN
bam-1791	120	21	in	in	ADP
bam-1791	120	22	snai1	snai1	ADJ
bam-1791	120	23	knocked	knock	VERB
bam-1791	120	24	-	-	PUNCT
bam-1791	120	25	down	down	ADP
bam-1791	120	26	cells	cell	NOUN
bam-1791	120	27	.	.	PUNCT
bam-1791	121	1	several	several	ADJ
bam-1791	121	2	downregulated	downregulate	VERB
bam-1791	121	3	genes	gene	NOUN
bam-1791	121	4	are	be	AUX
bam-1791	121	5	involved	involve	VERB
bam-1791	121	6	in	in	ADP
bam-1791	121	7	myoblasts	myoblast	NOUN
bam-1791	121	8	proliferation	proliferation	NOUN
bam-1791	121	9	,	,	PUNCT
bam-1791	121	10	extracellular	extracellular	ADJ
bam-1791	121	11	matrix	matrix	NOUN
bam-1791	121	12	formation	formation	NOUN
bam-1791	121	13	and	and	CCONJ
bam-1791	121	14	angiogenesis	angiogenesis	NOUN
bam-1791	121	15	,	,	PUNCT
bam-1791	121	16	suggesting	suggest	VERB
bam-1791	121	17	a	a	DET
bam-1791	121	18	role	role	NOUN
bam-1791	121	19	of	of	ADP
bam-1791	121	20	snai1	snai1	ADJ
bam-1791	121	21	in	in	ADP
bam-1791	121	22	myoblasts	myoblast	NOUN
bam-1791	121	23	expansion	expansion	NOUN
bam-1791	121	24	and	and	CCONJ
bam-1791	121	25	neo	neo	NOUN
bam-1791	121	26	-	-	NOUN
bam-1791	121	27	vascularization	vascularization	NOUN
bam-1791	121	28	in	in	ADP
bam-1791	121	29	early	early	ADJ
bam-1791	121	30	steps	step	NOUN
bam-1791	121	31	of	of	ADP
bam-1791	121	32	muscle	muscle	NOUN
bam-1791	121	33	regeneration	regeneration	NOUN
bam-1791	121	34	.	.	PUNCT
bam-1791	122	1	11	11	NUM
bam-1791	122	2	.	.	PUNCT
bam-1791	123	1	appropriate	appropriate	ADJ
bam-1791	123	2	levels	level	NOUN
bam-1791	123	3	of	of	ADP
bam-1791	123	4	extracellular	extracellular	ADJ
bam-1791	123	5	s100b	s100b	PROPN
bam-1791	123	6	protein	protein	NOUN
bam-1791	123	7	in	in	ADP
bam-1791	123	8	injured	injure	VERB
bam-1791	123	9	muscle	muscle	NOUN
bam-1791	123	10	are	be	AUX
bam-1791	123	11	required	require	VERB
bam-1791	123	12	for	for	ADP
bam-1791	123	13	correct	correct	ADJ
bam-1791	123	14	muscle	muscle	NOUN
bam-1791	123	15	regeneration	regeneration	NOUN
bam-1791	123	16	francesca	francesca	PROPN
bam-1791	123	17	riuzzi	riuzzi	NOUN
bam-1791	123	18	,	,	PUNCT
bam-1791	123	19	sara	sara	PROPN
bam-1791	123	20	beccafico	beccafico	PROPN
bam-1791	123	21	,	,	PUNCT
bam-1791	123	22	guglielmo	guglielmo	PROPN
bam-1791	123	23	sorci	sorci	VERB
bam-1791	123	24	,	,	PUNCT
bam-1791	123	25	and	and	CCONJ
bam-1791	123	26	rosario	rosario	PROPN
bam-1791	123	27	donato	donato	PROPN
bam-1791	123	28	dept	dept	PROPN
bam-1791	123	29	experimental	experimental	ADJ
bam-1791	123	30	medicine	medicine	PROPN
bam-1791	123	31	&	&	CCONJ
bam-1791	123	32	biochemical	biochemical	ADJ
bam-1791	123	33	sciences	sciences	PROPN
bam-1791	123	34	,	,	PUNCT
bam-1791	123	35	university	university	NOUN
bam-1791	123	36	of	of	ADP
bam-1791	123	37	perugia	perugia	PROPN
bam-1791	123	38	,	,	PUNCT
bam-1791	123	39	perugia	perugia	PROPN
bam-1791	123	40	,	,	PUNCT
bam-1791	123	41	italy	italy	PROPN
bam-1791	123	42	the	the	DET
bam-1791	123	43	ca2	ca2	PROPN
bam-1791	123	44	+	+	PROPN
bam-1791	123	45	-regulated	-regulated	ADJ
bam-1791	123	46	protein	protein	NOUN
bam-1791	123	47	and	and	CCONJ
bam-1791	123	48	damage	damage	NOUN
bam-1791	123	49	-	-	PUNCT
bam-1791	123	50	associated	associate	VERB
bam-1791	123	51	molecular	molecular	ADJ
bam-1791	123	52	pattern	pattern	NOUN
bam-1791	123	53	,	,	PUNCT
bam-1791	123	54	s100b	s100b	PROPN
bam-1791	123	55	,	,	PUNCT
bam-1791	123	56	is	be	AUX
bam-1791	123	57	promptly	promptly	ADV
bam-1791	123	58	released	release	VERB
bam-1791	123	59	by	by	ADP
bam-1791	123	60	muscle	muscle	NOUN
bam-1791	123	61	tissue	tissue	NOUN
bam-1791	123	62	upon	upon	SCONJ
bam-1791	123	63	acute	acute	ADJ
bam-1791	123	64	injury	injury	NOUN
bam-1791	123	65	and	and	CCONJ
bam-1791	123	66	contributes	contribute	VERB
bam-1791	123	67	to	to	ADP
bam-1791	123	68	the	the	DET
bam-1791	123	69	expansion	expansion	NOUN
bam-1791	123	70	of	of	ADP
bam-1791	123	71	muscle	muscle	NOUN
bam-1791	123	72	precursor	precursor	NOUN
bam-1791	123	73	cells	cell	NOUN
bam-1791	123	74	during	during	ADP
bam-1791	123	75	the	the	DET
bam-1791	123	76	early	early	ADJ
bam-1791	123	77	phase	phase	NOUN
bam-1791	123	78	of	of	ADP
bam-1791	123	79	muscle	muscle	NOUN
bam-1791	123	80	regeneration	regeneration	NOUN
bam-1791	123	81	by	by	ADP
bam-1791	123	82	binding	bind	VERB
bam-1791	123	83	to	to	ADP
bam-1791	123	84	rage	rage	NOUN
bam-1791	123	85	and	and	CCONJ
bam-1791	123	86	bfgf	bfgf	NOUN
bam-1791	123	87	/	/	SYM
bam-1791	123	88	fgfr1	fgfr1	NOUN
bam-1791	123	89	on	on	ADP
bam-1791	123	90	the	the	DET
bam-1791	123	91	myoblast	myoblast	ADJ
bam-1791	123	92	surface	surface	NOUN
bam-1791	124	1	[	[	X
bam-1791	124	2	1	1	NUM
bam-1791	124	3	]	]	PUNCT
bam-1791	124	4	.	.	PUNCT
bam-1791	125	1	however	however	ADV
bam-1791	125	2	,	,	PUNCT
bam-1791	125	3	during	during	ADP
bam-1791	125	4	the	the	DET
bam-1791	125	5	late	late	ADJ
bam-1791	125	6	phase	phase	NOUN
bam-1791	125	7	of	of	ADP
bam-1791	125	8	muscle	muscle	NOUN
bam-1791	125	9	regeneration	regeneration	NOUN
bam-1791	125	10	extracellular	extracellular	ADJ
bam-1791	125	11	s100b	s100b	PROPN
bam-1791	125	12	levels	level	NOUN
bam-1791	125	13	diminish	diminish	VERB
bam-1791	125	14	concomitant	concomitant	NOUN
bam-1791	125	15	with	with	ADP
bam-1791	125	16	myoblast	myoblast	ADJ
bam-1791	125	17	terminal	terminal	ADJ
bam-1791	125	18	differentiation	differentiation	NOUN
bam-1791	125	19	,	,	PUNCT
bam-1791	125	20	suggesting	suggest	VERB
bam-1791	125	21	that	that	SCONJ
bam-1791	125	22	appropriate	appropriate	ADJ
bam-1791	125	23	phase	phase	NOUN
bam-1791	125	24	-	-	PUNCT
bam-1791	125	25	specific	specific	ADJ
bam-1791	125	26	levels	level	NOUN
bam-1791	125	27	of	of	ADP
bam-1791	125	28	extracellular	extracellular	ADJ
bam-1791	125	29	s100b	s100b	PROPN
bam-1791	125	30	are	be	AUX
bam-1791	125	31	required	require	VERB
bam-1791	125	32	for	for	ADP
bam-1791	125	33	correct	correct	ADJ
bam-1791	125	34	muscle	muscle	NOUN
bam-1791	125	35	regeneration	regeneration	NOUN
bam-1791	125	36	[	[	X
bam-1791	125	37	2	2	NUM
bam-1791	125	38	]	]	PUNCT
bam-1791	125	39	.	.	PUNCT
bam-1791	126	1	to	to	PART
bam-1791	126	2	assess	assess	VERB
bam-1791	126	3	this	this	DET
bam-1791	126	4	point	point	NOUN
bam-1791	126	5	,	,	PUNCT
bam-1791	126	6	we	we	PRON
bam-1791	126	7	induced	induce	VERB
bam-1791	126	8	muscle	muscle	NOUN
bam-1791	126	9	injury	injury	NOUN
bam-1791	126	10	in	in	ADP
bam-1791	126	11	the	the	DET
bam-1791	126	12	tibialis	tibialis	PROPN
bam-1791	126	13	anterior	anterior	ADJ
bam-1791	126	14	muscle	muscle	NOUN
bam-1791	126	15	of	of	ADP
bam-1791	126	16	c57bl/6	c57bl/6	NOUN
bam-1791	126	17	mice	mouse	NOUN
bam-1791	126	18	and	and	CCONJ
bam-1791	126	19	subsequently	subsequently	ADV
bam-1791	126	20	inoculated	inoculate	VERB
bam-1791	126	21	the	the	DET
bam-1791	126	22	damaged	damage	VERB
bam-1791	126	23	muscle	muscle	NOUN
bam-1791	126	24	with	with	ADP
bam-1791	126	25	non	non	ADJ
bam-1791	126	26	-	-	ADJ
bam-1791	126	27	immune	immune	ADJ
bam-1791	126	28	igg	igg	NOUN
bam-1791	126	29	or	or	CCONJ
bam-1791	126	30	an	an	DET
bam-1791	126	31	s100b	s100b	PROPN
bam-1791	126	32	neutralizing	neutralize	VERB
bam-1791	126	33	antibody	antibody	NOUN
bam-1791	126	34	during	during	ADP
bam-1791	126	35	the	the	DET
bam-1791	126	36	first	first	ADJ
bam-1791	126	37	days	day	NOUN
bam-1791	126	38	of	of	ADP
bam-1791	126	39	regeneration	regeneration	NOUN
bam-1791	126	40	.	.	PUNCT
bam-1791	127	1	we	we	PRON
bam-1791	127	2	found	find	VERB
bam-1791	127	3	that	that	SCONJ
bam-1791	127	4	sequestering	sequester	VERB
bam-1791	127	5	extracellular	extracellular	ADJ
bam-1791	127	6	s100b	s100b	PROPN
bam-1791	127	7	up	up	ADP
bam-1791	127	8	to	to	ADP
bam-1791	127	9	post	post	ADJ
bam-1791	127	10	-	-	ADJ
bam-1791	127	11	injury	injury	ADJ
bam-1791	127	12	day	day	NOUN
bam-1791	127	13	3	3	NUM
bam-1791	127	14	resulted	result	VERB
bam-1791	127	15	in	in	ADP
bam-1791	127	16	impaired	impaired	ADJ
bam-1791	127	17	muscle	muscle	NOUN
bam-1791	127	18	regeneration	regeneration	NOUN
bam-1791	127	19	characterized	characterize	VERB
bam-1791	127	20	by	by	ADP
bam-1791	127	21	a	a	DET
bam-1791	127	22	dramatic	dramatic	ADJ
bam-1791	127	23	reduction	reduction	NOUN
bam-1791	127	24	of	of	ADP
bam-1791	127	25	the	the	DET
bam-1791	127	26	number	number	NOUN
bam-1791	127	27	of	of	ADP
bam-1791	127	28	infiltrated	infiltrate	VERB
bam-1791	127	29	macrophages	macrophage	NOUN
bam-1791	127	30	,	,	PUNCT
bam-1791	127	31	which	which	PRON
bam-1791	127	32	resulted	result	VERB
bam-1791	127	33	prevalently	prevalently	ADV
bam-1791	127	34	in	in	ADP
bam-1791	127	35	the	the	DET
bam-1791	127	36	m1	m1	NOUN
bam-1791	127	37	activation	activation	NOUN
bam-1791	127	38	state	state	NOUN
bam-1791	127	39	compared	compare	VERB
bam-1791	127	40	with	with	ADP
bam-1791	127	41	igg	igg	PROPN
bam-1791	127	42	-	-	PUNCT
bam-1791	127	43	injected	inject	VERB
bam-1791	127	44	muscles	muscle	NOUN
bam-1791	127	45	,	,	PUNCT
bam-1791	127	46	and	and	CCONJ
bam-1791	127	47	a	a	DET
bam-1791	127	48	reduction	reduction	NOUN
bam-1791	127	49	of	of	ADP
bam-1791	127	50	the	the	DET
bam-1791	127	51	number	number	NOUN
bam-1791	127	52	of	of	ADP
bam-1791	127	53	proliferating	proliferate	VERB
bam-1791	127	54	and	and	CCONJ
bam-1791	127	55	differentiating	differentiate	VERB
bam-1791	127	56	satellite	satellite	NOUN
bam-1791	127	57	cells	cell	NOUN
bam-1791	127	58	.	.	PUNCT
bam-1791	128	1	i.p	i.p	PROPN
bam-1791	128	2	.	.	PROPN
bam-1791	128	3	injection	injection	NOUN
bam-1791	128	4	of	of	ADP
bam-1791	128	5	anti	anti	ADJ
bam-1791	128	6	-	-	ADJ
bam-1791	128	7	s100b	s100b	ADJ
bam-1791	128	8	antibody	antibody	NOUN
bam-1791	128	9	gave	give	VERB
bam-1791	128	10	similar	similar	ADJ
bam-1791	128	11	results	result	NOUN
bam-1791	128	12	to	to	ADP
bam-1791	128	13	local	local	ADJ
bam-1791	128	14	injection	injection	NOUN
bam-1791	128	15	.	.	PUNCT
bam-1791	129	1	similar	similar	ADJ
bam-1791	129	2	experiments	experiment	NOUN
bam-1791	129	3	performed	perform	VERB
bam-1791	129	4	in	in	ADP
bam-1791	129	5	rage-/mice	rage-/mice	NUM
bam-1791	129	6	suggested	suggest	VERB
bam-1791	129	7	that	that	SCONJ
bam-1791	129	8	the	the	DET
bam-1791	129	9	effects	effect	NOUN
bam-1791	129	10	of	of	ADP
bam-1791	129	11	s100b	s100b	PROPN
bam-1791	129	12	were	be	AUX
bam-1791	129	13	rage	rage	NOUN
bam-1791	129	14	-	-	PUNCT
bam-1791	129	15	dependent	dependent	ADJ
bam-1791	129	16	.	.	PUNCT
bam-1791	130	1	however	however	ADV
bam-1791	130	2	,	,	PUNCT
bam-1791	130	3	repeated	repeat	VERB
bam-1791	130	4	i.m	i.m	PROPN
bam-1791	130	5	.	.	PUNCT
bam-1791	130	6	injections	injection	NOUN
bam-1791	130	7	of	of	ADP
bam-1791	130	8	s100b	s100b	PROPN
bam-1791	130	9	during	during	ADP
bam-1791	130	10	the	the	DET
bam-1791	130	11	regenerative	regenerative	ADJ
bam-1791	130	12	process	process	NOUN
bam-1791	130	13	translated	translate	VERB
bam-1791	130	14	into	into	ADP
bam-1791	130	15	a	a	DET
bam-1791	130	16	significant	significant	ADJ
bam-1791	130	17	increase	increase	NOUN
bam-1791	130	18	in	in	ADP
bam-1791	130	19	the	the	DET
bam-1791	130	20	recruitment	recruitment	NOUN
bam-1791	130	21	of	of	ADP
bam-1791	130	22	overstaying	overstay	VERB
bam-1791	130	23	macrophages	macrophage	NOUN
bam-1791	130	24	and	and	CCONJ
bam-1791	130	25	impaired	impaired	ADJ
bam-1791	130	26	regeneration	regeneration	NOUN
bam-1791	130	27	,	,	PUNCT
bam-1791	130	28	suggesting	suggest	VERB
bam-1791	130	29	that	that	SCONJ
bam-1791	130	30	s100b	s100b	PROPN
bam-1791	130	31	may	may	AUX
bam-1791	130	32	act	act	VERB
bam-1791	130	33	as	as	ADP
bam-1791	130	34	a	a	DET
bam-1791	130	35	chemoattractant	chemoattractant	NOUN
bam-1791	130	36	for	for	ADP
bam-1791	130	37	macrophages	macrophage	NOUN
bam-1791	130	38	,	,	PUNCT
bam-1791	130	39	as	as	SCONJ
bam-1791	130	40	supported	support	VERB
bam-1791	130	41	by	by	ADP
bam-1791	130	42	in	in	ADP
bam-1791	130	43	vitro	vitro	X
bam-1791	130	44	experiments	experiment	NOUN
bam-1791	130	45	.	.	PUNCT
bam-1791	131	1	because	because	SCONJ
bam-1791	131	2	we	we	PRON
bam-1791	131	3	found	find	VERB
bam-1791	131	4	higher	high	ADJ
bam-1791	131	5	levels	level	NOUN
bam-1791	131	6	of	of	ADP
bam-1791	131	7	released	release	VERB
bam-1791	131	8	s100b	s100b	PROPN
bam-1791	131	9	in	in	ADP
bam-1791	131	10	muscles	muscle	NOUN
bam-1791	131	11	of	of	ADP
bam-1791	131	12	dystrophic	dystrophic	ADJ
bam-1791	131	13	(	(	PUNCT
bam-1791	131	14	mdx	mdx	NOUN
bam-1791	131	15	)	)	PUNCT
bam-1791	131	16	mice	mouse	NOUN
bam-1791	131	17	compared	compare	VERB
bam-1791	131	18	with	with	ADP
bam-1791	131	19	wt	wt	ADP
bam-1791	131	20	mice	mouse	NOUN
bam-1791	131	21	,	,	PUNCT
bam-1791	131	22	our	our	PRON
bam-1791	131	23	data	datum	NOUN
bam-1791	131	24	suggest	suggest	VERB
bam-1791	131	25	that	that	SCONJ
bam-1791	131	26	appropriate	appropriate	ADJ
bam-1791	131	27	levels	level	NOUN
bam-1791	131	28	of	of	ADP
bam-1791	131	29	extracellular	extracellular	ADJ
bam-1791	131	30	s100b	s100b	PROPN
bam-1791	131	31	are	be	AUX
bam-1791	131	32	required	require	VERB
bam-1791	131	33	at	at	ADP
bam-1791	131	34	specific	specific	ADJ
bam-1791	131	35	phases	phase	NOUN
bam-1791	131	36	of	of	ADP
bam-1791	131	37	muscle	muscle	NOUN
bam-1791	131	38	regeneration	regeneration	NOUN
bam-1791	131	39	for	for	ADP
bam-1791	131	40	efficient	efficient	ADJ
bam-1791	131	41	regeneration	regeneration	NOUN
bam-1791	131	42	,	,	PUNCT
bam-1791	131	43	and	and	CCONJ
bam-1791	131	44	that	that	SCONJ
bam-1791	131	45	chronic	chronic	ADJ
bam-1791	131	46	release	release	NOUN
bam-1791	131	47	of	of	ADP
bam-1791	131	48	s100b	s100b	PROPN
bam-1791	131	49	in	in	ADP
bam-1791	131	50	muscular	muscular	ADJ
bam-1791	131	51	dystrophy	dystrophy	NOUN
bam-1791	131	52	might	might	AUX
bam-1791	131	53	concur	concur	VERB
bam-1791	131	54	to	to	ADP
bam-1791	131	55	the	the	DET
bam-1791	131	56	disease	disease	NOUN
bam-1791	131	57	.	.	PUNCT
bam-1791	132	1	12	12	NUM
bam-1791	132	2	.	.	PUNCT
bam-1791	132	3	collagen	collagen	PROPN
bam-1791	132	4	vi	vi	PROPN
bam-1791	132	5	enhances	enhance	VERB
bam-1791	132	6	satellite	satellite	NOUN
bam-1791	132	7	cell	cell	NOUN
bam-1791	132	8	self	self	NOUN
bam-1791	132	9	-	-	PUNCT
bam-1791	132	10	renewal	renewal	NOUN
bam-1791	132	11	and	and	CCONJ
bam-1791	132	12	muscle	muscle	NOUN
bam-1791	132	13	regeneration	regeneration	NOUN
bam-1791	132	14	anna	anna	NOUN
bam-1791	132	15	urciuolo1	urciuolo1	PROPN
bam-1791	132	16	,	,	PUNCT
bam-1791	132	17	valeria	valeria	PROPN
bam-1791	132	18	morbidoni1	morbidoni1	PROPN
bam-1791	132	19	,	,	PUNCT
bam-1791	132	20	francesca	francesca	PROPN
bam-1791	132	21	gattazzo1	gattazzo1	PROPN
bam-1791	132	22	,	,	PUNCT
bam-1791	132	23	sibilla	sibilla	PROPN
bam-1791	132	24	molon1	molon1	PROPN
bam-1791	132	25	,	,	PUNCT
bam-1791	132	26	paolo	paolo	PROPN
bam-1791	132	27	grumati1	grumati1	PROPN
bam-1791	132	28	,	,	PUNCT
bam-1791	132	29	marco	marco	PROPN
bam-1791	132	30	quarta2	quarta2	PROPN
bam-1791	132	31	,	,	PUNCT
bam-1791	132	32	francesco	francesco	PROPN
bam-1791	132	33	saverio	saverio	PROPN
bam-1791	132	34	tedesco3	tedesco3	PROPN
bam-1791	132	35	,	,	PUNCT
bam-1791	132	36	giulio	giulio	PROPN
bam-1791	132	37	cossu3	cossu3	PROPN
bam-1791	132	38	,	,	PUNCT
bam-1791	132	39	thomas	thomas	PROPN
bam-1791	132	40	a.	a.	PROPN
bam-1791	132	41	rando2	rando2	PROPN
bam-1791	132	42	,	,	PUNCT
bam-1791	132	43	paolo	paolo	ADJ
bam-1791	132	44	bonaldo1	bonaldo1	NOUN
bam-1791	132	45	1	1	NUM
bam-1791	132	46	department	department	NOUN
bam-1791	132	47	of	of	ADP
bam-1791	132	48	biomedical	biomedical	ADJ
bam-1791	132	49	sciences	sciences	PROPN
bam-1791	132	50	,	,	PUNCT
bam-1791	132	51	university	university	PROPN
bam-1791	132	52	of	of	ADP
bam-1791	132	53	padova	padova	PROPN
bam-1791	132	54	,	,	PUNCT
bam-1791	132	55	padova	padova	PROPN
bam-1791	132	56	35131	35131	NUM
bam-1791	132	57	,	,	PUNCT
bam-1791	132	58	italy	italy	PROPN
bam-1791	132	59	.	.	PROPN
bam-1791	133	1	2	2	NUM
bam-1791	133	2	department	department	NOUN
bam-1791	133	3	of	of	ADP
bam-1791	133	4	neurology	neurology	NOUN
bam-1791	133	5	and	and	CCONJ
bam-1791	133	6	neurological	neurological	ADJ
bam-1791	133	7	sciences	science	NOUN
bam-1791	133	8	,	,	PUNCT
bam-1791	133	9	and	and	CCONJ
bam-1791	133	10	the	the	DET
bam-1791	133	11	glenn	glenn	PROPN
bam-1791	133	12	laboratories	laboratory	NOUN
bam-1791	133	13	for	for	ADP
bam-1791	133	14	the	the	DET
bam-1791	133	15	biology	biology	NOUN
bam-1791	133	16	of	of	ADP
bam-1791	133	17	aging	aging	NOUN
bam-1791	133	18	,	,	PUNCT
bam-1791	133	19	stanford	stanford	PROPN
bam-1791	133	20	university	university	PROPN
bam-1791	133	21	school	school	NOUN
bam-1791	133	22	of	of	ADP
bam-1791	133	23	medicine	medicine	NOUN
bam-1791	133	24	,	,	PUNCT
bam-1791	133	25	stanford	stanford	PROPN
bam-1791	133	26	,	,	PUNCT
bam-1791	133	27	ca	ca	PROPN
bam-1791	133	28	94305	94305	NUM
bam-1791	133	29	,	,	PUNCT
bam-1791	133	30	usa	usa	PROPN
bam-1791	133	31	.	.	PROPN
bam-1791	134	1	3department	3department	NUM
bam-1791	134	2	of	of	ADP
bam-1791	134	3	cell	cell	NOUN
bam-1791	134	4	and	and	CCONJ
bam-1791	134	5	developmental	developmental	ADJ
bam-1791	134	6	biology	biology	NOUN
bam-1791	134	7	,	,	PUNCT
bam-1791	134	8	university	university	NOUN
bam-1791	134	9	college	college	PROPN
bam-1791	134	10	london	london	PROPN
bam-1791	134	11	,	,	PUNCT
bam-1791	134	12	wc1e	wc1e	PROPN
bam-1791	134	13	6de	6de	NOUN
bam-1791	134	14	,	,	PUNCT
bam-1791	134	15	collagen	collagen	PROPN
bam-1791	134	16	vi	vi	PROPN
bam-1791	134	17	(	(	PUNCT
bam-1791	134	18	colvi	colvi	PROPN
bam-1791	134	19	)	)	PUNCT
bam-1791	134	20	is	be	AUX
bam-1791	134	21	an	an	DET
bam-1791	134	22	extracellular	extracellular	ADJ
bam-1791	134	23	matrix	matrix	NOUN
bam-1791	134	24	protein	protein	NOUN
bam-1791	134	25	composed	compose	VERB
bam-1791	134	26	by	by	ADP
bam-1791	134	27	three	three	NUM
bam-1791	134	28	alpha	alpha	NOUN
bam-1791	134	29	-	-	PUNCT
bam-1791	134	30	chains	chain	NOUN
bam-1791	134	31	encoded	encode	VERB
bam-1791	134	32	by	by	ADP
bam-1791	134	33	different	different	ADJ
bam-1791	134	34	genes	gene	NOUN
bam-1791	134	35	and	and	CCONJ
bam-1791	134	36	forming	form	VERB
bam-1791	134	37	a	a	DET
bam-1791	134	38	microfilamentous	microfilamentous	ADJ
bam-1791	134	39	network	network	NOUN
bam-1791	134	40	in	in	ADP
bam-1791	134	41	different	different	ADJ
bam-1791	134	42	tissues	tissue	NOUN
bam-1791	134	43	.	.	PUNCT
bam-1791	135	1	in	in	ADP
bam-1791	135	2	skeletal	skeletal	ADJ
bam-1791	135	3	muscles	muscle	NOUN
bam-1791	135	4	,	,	PUNCT
bam-1791	135	5	colvi	colvi	NOUN
bam-1791	135	6	deposition	deposition	NOUN
bam-1791	135	7	is	be	AUX
bam-1791	135	8	mainly	mainly	ADV
bam-1791	135	9	provided	provide	VERB
bam-1791	135	10	by	by	ADP
bam-1791	135	11	interstitial	interstitial	ADJ
bam-1791	135	12	muscular	muscular	ADJ
bam-1791	135	13	fibroblasts	fibroblast	NOUN
bam-1791	135	14	and	and	CCONJ
bam-1791	135	15	the	the	DET
bam-1791	135	16	protein	protein	NOUN
bam-1791	135	17	localizes	localize	VERB
bam-1791	135	18	in	in	ADP
bam-1791	135	19	the	the	DET
bam-1791	135	20	endomysium	endomysium	NOUN
bam-1791	135	21	surrounding	surround	VERB
bam-1791	135	22	muscle	muscle	NOUN
bam-1791	135	23	fibers	fiber	NOUN
bam-1791	135	24	.	.	PUNCT
bam-1791	136	1	the	the	DET
bam-1791	136	2	critical	critical	ADJ
bam-1791	136	3	role	role	NOUN
bam-1791	136	4	of	of	ADP
bam-1791	136	5	colvi	colvi	NOUN
bam-1791	136	6	in	in	ADP
bam-1791	136	7	skeletal	skeletal	ADJ
bam-1791	136	8	muscle	muscle	NOUN
bam-1791	136	9	is	be	AUX
bam-1791	136	10	supported	support	VERB
bam-1791	136	11	by	by	ADP
bam-1791	136	12	the	the	DET
bam-1791	136	13	fact	fact	NOUN
bam-1791	136	14	that	that	SCONJ
bam-1791	136	15	mutations	mutation	NOUN
bam-1791	136	16	of	of	ADP
bam-1791	136	17	col6a1	col6a1	NOUN
bam-1791	136	18	-	-	PUNCT
bam-1791	136	19	col6a3	col6a3	NOUN
bam-1791	136	20	genes	gene	NOUN
bam-1791	136	21	cause	cause	VERB
bam-1791	136	22	various	various	ADJ
bam-1791	136	23	forms	form	NOUN
bam-1791	136	24	of	of	ADP
bam-1791	136	25	inherited	inherit	VERB
bam-1791	136	26	muscle	muscle	NOUN
bam-1791	136	27	disorders	disorder	NOUN
bam-1791	136	28	.	.	PUNCT
bam-1791	137	1	satellite	satellite	NOUN
bam-1791	137	2	cells	cell	NOUN
bam-1791	137	3	(	(	PUNCT
bam-1791	137	4	scs	scs	PROPN
bam-1791	137	5	)	)	PUNCT
bam-1791	137	6	are	be	AUX
bam-1791	137	7	the	the	DET
bam-1791	137	8	adult	adult	NOUN
bam-1791	137	9	skeletal	skeletal	ADJ
bam-1791	137	10	muscle	muscle	NOUN
bam-1791	137	11	stem	stem	NOUN
bam-1791	137	12	cells	cell	NOUN
bam-1791	137	13	and	and	CCONJ
bam-1791	137	14	play	play	VERB
bam-1791	137	15	essential	essential	ADJ
bam-1791	137	16	roles	role	NOUN
bam-1791	137	17	in	in	ADP
bam-1791	137	18	the	the	DET
bam-1791	137	19	ix	ix	PROPN
bam-1791	137	20	iim	iim	PROPN
bam-1791	137	21	meeting	meeting	NOUN
bam-1791	137	22	,	,	PUNCT
bam-1791	137	23	acaya	acaya	NOUN
bam-1791	137	24	(	(	PUNCT
bam-1791	137	25	lecce	lecce	PROPN
bam-1791	137	26	)	)	PUNCT
bam-1791	137	27	,	,	PUNCT
bam-1791	137	28	october	october	PROPN
bam-1791	137	29	12	12	NUM
bam-1791	137	30	-	-	SYM
bam-1791	137	31	14	14	NUM
bam-1791	137	32	,	,	PUNCT
bam-1791	137	33	2012	2012	NUM
bam-1791	137	34	european	european	PROPN
bam-1791	137	35	journal	journal	PROPN
bam-1791	137	36	translational	translational	ADJ
bam-1791	137	37	myology	myology	NOUN
bam-1791	137	38	basic	basic	ADJ
bam-1791	137	39	applied	apply	VERB
bam-1791	137	40	myology	myology	NOUN
bam-1791	137	41	2012	2012	NUM
bam-1791	137	42	;	;	PUNCT
bam-1791	137	43	22(1&2	22(1&2	NUM
bam-1791	137	44	):	):	PUNCT
bam-1791	137	45	xxx	xxx	NOUN
bam-1791	137	46	-	-	PUNCT
bam-1791	137	47	xxx	xxx	NOUN
bam-1791	137	48	25	25	NUM
bam-1791	137	49	homeostasis	homeostasis	NOUN
bam-1791	137	50	and	and	CCONJ
bam-1791	137	51	regeneration	regeneration	NOUN
bam-1791	137	52	of	of	ADP
bam-1791	137	53	skeletal	skeletal	ADJ
bam-1791	137	54	muscles	muscle	NOUN
bam-1791	137	55	.	.	PUNCT
bam-1791	138	1	scs	scs	PROPN
bam-1791	138	2	are	be	AUX
bam-1791	138	3	located	locate	VERB
bam-1791	138	4	within	within	ADP
bam-1791	138	5	a	a	DET
bam-1791	138	6	niche	niche	NOUN
bam-1791	138	7	that	that	PRON
bam-1791	138	8	includes	include	VERB
bam-1791	138	9	myofibers	myofiber	NOUN
bam-1791	138	10	and	and	CCONJ
bam-1791	138	11	extracellular	extracellular	ADJ
bam-1791	138	12	matrix	matrix	NOUN
bam-1791	138	13	.	.	PUNCT
bam-1791	139	1	currently	currently	ADV
bam-1791	139	2	,	,	PUNCT
bam-1791	139	3	the	the	DET
bam-1791	139	4	function	function	NOUN
bam-1791	139	5	of	of	ADP
bam-1791	139	6	specific	specific	ADJ
bam-1791	139	7	extracellular	extracellular	ADJ
bam-1791	139	8	matrix	matrix	NOUN
bam-1791	139	9	molecules	molecule	NOUN
bam-1791	139	10	in	in	ADP
bam-1791	139	11	regulating	regulate	VERB
bam-1791	139	12	scs	scs	PROPN
bam-1791	139	13	is	be	AUX
bam-1791	139	14	unknown	unknown	ADJ
bam-1791	139	15	.	.	PUNCT
bam-1791	140	1	here	here	ADV
bam-1791	140	2	,	,	PUNCT
bam-1791	140	3	we	we	PRON
bam-1791	140	4	investigated	investigate	VERB
bam-1791	140	5	whether	whether	SCONJ
bam-1791	140	6	colvi	colvi	PROPN
bam-1791	140	7	plays	play	VERB
bam-1791	140	8	any	any	DET
bam-1791	140	9	role	role	NOUN
bam-1791	140	10	in	in	ADP
bam-1791	140	11	regulating	regulate	VERB
bam-1791	140	12	sc	sc	NOUN
bam-1791	140	13	activity	activity	NOUN
bam-1791	140	14	.	.	PUNCT
bam-1791	141	1	colvi	colvi	PROPN
bam-1791	141	2	was	be	AUX
bam-1791	141	3	found	find	VERB
bam-1791	141	4	to	to	PART
bam-1791	141	5	be	be	AUX
bam-1791	141	6	a	a	DET
bam-1791	141	7	component	component	NOUN
bam-1791	141	8	of	of	ADP
bam-1791	141	9	sc	sc	PROPN
bam-1791	141	10	niche	niche	NOUN
bam-1791	141	11	in	in	ADP
bam-1791	141	12	vivo	vivo	NOUN
bam-1791	141	13	and	and	CCONJ
bam-1791	141	14	the	the	DET
bam-1791	141	15	native	native	ADJ
bam-1791	141	16	protein	protein	NOUN
bam-1791	141	17	was	be	AUX
bam-1791	141	18	able	able	ADJ
bam-1791	141	19	to	to	PART
bam-1791	141	20	ameliorate	ameliorate	VERB
bam-1791	141	21	the	the	DET
bam-1791	141	22	in	in	ADV
bam-1791	141	23	vitro	vitro	X
bam-1791	141	24	self	self	NOUN
bam-1791	141	25	-	-	PUNCT
bam-1791	141	26	renewal	renewal	NOUN
bam-1791	141	27	of	of	ADP
bam-1791	141	28	scs	scs	PROPN
bam-1791	141	29	.	.	PROPN
bam-1791	141	30	colvi	colvi	PROPN
bam-1791	141	31	null	null	NOUN
bam-1791	141	32	(	(	PUNCT
bam-1791	141	33	col6a1–/	col6a1–/	ADJ
bam-1791	141	34	–	–	PUNCT
bam-1791	141	35	)	)	PUNCT
bam-1791	141	36	scs	scs	PROPN
bam-1791	141	37	displayed	display	VERB
bam-1791	141	38	decreased	decrease	VERB
bam-1791	141	39	in	in	ADP
bam-1791	141	40	vitro	vitro	X
bam-1791	141	41	self	self	NOUN
bam-1791	141	42	-	-	PUNCT
bam-1791	141	43	renewal	renewal	NOUN
bam-1791	141	44	capability	capability	NOUN
bam-1791	141	45	,	,	PUNCT
bam-1791	141	46	a	a	DET
bam-1791	141	47	phenotype	phenotype	NOUN
bam-1791	141	48	rescued	rescue	VERB
bam-1791	141	49	by	by	ADP
bam-1791	141	50	plating	plate	VERB
bam-1791	141	51	onto	onto	ADP
bam-1791	141	52	native	native	ADJ
bam-1791	141	53	colvi	colvi	PROPN
bam-1791	141	54	.	.	PUNCT
bam-1791	142	1	moreover	moreover	ADV
bam-1791	142	2	,	,	PUNCT
bam-1791	142	3	lack	lack	NOUN
bam-1791	142	4	of	of	ADP
bam-1791	142	5	colvi	colvi	NOUN
bam-1791	142	6	in	in	ADP
bam-1791	142	7	col6a1–/	col6a1–/	NOUN
bam-1791	142	8	–	–	PUNCT
bam-1791	142	9	mice	mouse	NOUN
bam-1791	142	10	caused	cause	VERB
bam-1791	142	11	impaired	impaired	ADJ
bam-1791	142	12	muscle	muscle	NOUN
bam-1791	142	13	regeneration	regeneration	NOUN
bam-1791	142	14	and	and	CCONJ
bam-1791	142	15	reduced	reduce	VERB
bam-1791	142	16	sc	sc	PROPN
bam-1791	142	17	self	self	NOUN
bam-1791	142	18	-	-	PUNCT
bam-1791	142	19	renewal	renewal	NOUN
bam-1791	142	20	capability	capability	NOUN
bam-1791	142	21	after	after	ADP
bam-1791	142	22	injury	injury	NOUN
bam-1791	142	23	.	.	PUNCT
bam-1791	143	1	when	when	SCONJ
bam-1791	143	2	colvi	colvi	PROPN
bam-1791	143	3	deposition	deposition	NOUN
bam-1791	143	4	was	be	AUX
bam-1791	143	5	reinstated	reinstate	VERB
bam-1791	143	6	in	in	ADP
bam-1791	143	7	vivo	vivo	NOUN
bam-1791	143	8	by	by	ADP
bam-1791	143	9	grafting	graft	VERB
bam-1791	143	10	wild	wild	ADJ
bam-1791	143	11	-	-	PUNCT
bam-1791	143	12	type	type	NOUN
bam-1791	143	13	fibroblasts	fibroblast	NOUN
bam-1791	143	14	,	,	PUNCT
bam-1791	143	15	the	the	DET
bam-1791	143	16	sc	sc	PROPN
bam-1791	143	17	defects	defect	NOUN
bam-1791	143	18	of	of	ADP
bam-1791	143	19	col6a1–/	col6a1–/	NOUN
bam-1791	143	20	–	–	PUNCT
bam-1791	143	21	mice	mouse	NOUN
bam-1791	143	22	were	be	AUX
bam-1791	143	23	rescued	rescue	VERB
bam-1791	143	24	.	.	PUNCT
bam-1791	144	1	these	these	DET
bam-1791	144	2	data	datum	NOUN
bam-1791	144	3	indicate	indicate	VERB
bam-1791	144	4	that	that	SCONJ
bam-1791	144	5	colvi	colvi	PROPN
bam-1791	144	6	plays	play	VERB
bam-1791	144	7	a	a	DET
bam-1791	144	8	key	key	ADJ
bam-1791	144	9	role	role	NOUN
bam-1791	144	10	in	in	ADP
bam-1791	144	11	the	the	DET
bam-1791	144	12	regulation	regulation	NOUN
bam-1791	144	13	of	of	ADP
bam-1791	144	14	sc	sc	NOUN
bam-1791	144	15	activity	activity	NOUN
bam-1791	144	16	,	,	PUNCT
bam-1791	144	17	and	and	CCONJ
bam-1791	144	18	they	they	PRON
bam-1791	144	19	open	open	VERB
bam-1791	144	20	novel	novel	ADJ
bam-1791	144	21	therapeutic	therapeutic	ADJ
bam-1791	144	22	venues	venue	NOUN
bam-1791	144	23	for	for	ADP
bam-1791	144	24	colvi	colvi	NOUN
bam-1791	144	25	-	-	PUNCT
bam-1791	144	26	related	relate	VERB
bam-1791	144	27	muscular	muscular	ADJ
bam-1791	144	28	dystrophies	dystrophy	NOUN
bam-1791	144	29	.	.	PUNCT
bam-1791	145	1	13	13	NUM
bam-1791	145	2	.	.	PUNCT
bam-1791	145	3	macrophages	macrophage	NOUN
bam-1791	145	4	and	and	CCONJ
bam-1791	145	5	muscle	muscle	NOUN
bam-1791	145	6	regeneration	regeneration	NOUN
bam-1791	145	7	:	:	PUNCT
bam-1791	145	8	who	who	PRON
bam-1791	145	9	did	do	AUX
bam-1791	145	10	you	you	PRON
bam-1791	145	11	call	call	VERB
bam-1791	145	12	a	a	DET
bam-1791	145	13	scavenger	scavenger	NOUN
bam-1791	145	14	?	?	PUNCT
bam-1791	146	1	eva	eva	PROPN
bam-1791	146	2	galletta1	galletta1	PROPN
bam-1791	146	3	,	,	PUNCT
bam-1791	146	4	chiara	chiara	PROPN
bam-1791	146	5	saletti1	saletti1	PROPN
bam-1791	146	6	,	,	PUNCT
bam-1791	146	7	federico	federico	PROPN
bam-1791	146	8	galvagni2	galvagni2	PROPN
bam-1791	146	9	,	,	PUNCT
bam-1791	146	10	chiara	chiara	X
bam-1791	146	11	bolego3	bolego3	NOUN
bam-1791	146	12	and	and	CCONJ
bam-1791	146	13	libero	libero	PROPN
bam-1791	146	14	vitiello1	vitiello1	PROPN
bam-1791	146	15	1	1	NUM
bam-1791	146	16	:	:	PUNCT
bam-1791	146	17	department	department	NOUN
bam-1791	146	18	of	of	ADP
bam-1791	146	19	biology	biology	NOUN
bam-1791	146	20	,	,	PUNCT
bam-1791	146	21	university	university	PROPN
bam-1791	146	22	of	of	ADP
bam-1791	146	23	padova	padova	PROPN
bam-1791	146	24	,	,	PUNCT
bam-1791	146	25	italy	italy	PROPN
bam-1791	146	26	2	2	NUM
bam-1791	146	27	:	:	PUNCT
bam-1791	146	28	department	department	NOUN
bam-1791	146	29	of	of	ADP
bam-1791	146	30	biotechnology	biotechnology	NOUN
bam-1791	146	31	,	,	PUNCT
bam-1791	146	32	university	university	PROPN
bam-1791	146	33	of	of	ADP
bam-1791	146	34	siena	siena	PROPN
bam-1791	146	35	,	,	PUNCT
bam-1791	146	36	italy	italy	PROPN
bam-1791	146	37	3	3	NUM
bam-1791	146	38	:	:	PUNCT
bam-1791	146	39	department	department	NOUN
bam-1791	146	40	of	of	ADP
bam-1791	146	41	pharmacy	pharmacy	NOUN
bam-1791	146	42	,	,	PUNCT
bam-1791	146	43	university	university	PROPN
bam-1791	146	44	of	of	ADP
bam-1791	146	45	padova	padova	PROPN
bam-1791	146	46	,	,	PUNCT
bam-1791	146	47	italy	italy	PROPN
bam-1791	146	48	muscle	muscle	PROPN
bam-1791	146	49	regeneration	regeneration	NOUN
bam-1791	146	50	is	be	AUX
bam-1791	146	51	a	a	DET
bam-1791	146	52	complex	complex	ADJ
bam-1791	146	53	process	process	NOUN
bam-1791	146	54	that	that	PRON
bam-1791	146	55	involves	involve	VERB
bam-1791	146	56	many	many	ADJ
bam-1791	146	57	different	different	ADJ
bam-1791	146	58	types	type	NOUN
bam-1791	146	59	of	of	ADP
bam-1791	146	60	cells	cell	NOUN
bam-1791	146	61	,	,	PUNCT
bam-1791	146	62	both	both	PRON
bam-1791	146	63	myogenic	myogenic	ADJ
bam-1791	146	64	and	and	CCONJ
bam-1791	146	65	nonmyogenic	nonmyogenic	ADJ
bam-1791	146	66	.	.	PUNCT
bam-1791	147	1	in	in	ADP
bam-1791	147	2	particular	particular	ADJ
bam-1791	147	3	,	,	PUNCT
bam-1791	147	4	macrophages	macrophage	NOUN
bam-1791	147	5	play	play	VERB
bam-1791	147	6	a	a	DET
bam-1791	147	7	fundamental	fundamental	ADJ
bam-1791	147	8	role	role	NOUN
bam-1791	147	9	:	:	PUNCT
bam-1791	147	10	they	they	PRON
bam-1791	147	11	phagocyte	phagocyte	VERB
bam-1791	147	12	debris	debris	NOUN
bam-1791	147	13	,	,	PUNCT
bam-1791	147	14	release	release	VERB
bam-1791	147	15	cytokines	cytokine	NOUN
bam-1791	147	16	to	to	PART
bam-1791	147	17	regulate	regulate	VERB
bam-1791	147	18	inflammatory	inflammatory	ADJ
bam-1791	147	19	response	response	NOUN
bam-1791	147	20	and	and	CCONJ
bam-1791	147	21	stimulate	stimulate	VERB
bam-1791	147	22	satellite	satellite	NOUN
bam-1791	147	23	cells	cell	NOUN
bam-1791	147	24	proliferation	proliferation	NOUN
bam-1791	147	25	.	.	PUNCT
bam-1791	148	1	in	in	ADP
bam-1791	148	2	vivo	vivo	NOUN
bam-1791	148	3	,	,	PUNCT
bam-1791	148	4	there	there	PRON
bam-1791	148	5	are	be	VERB
bam-1791	148	6	two	two	NUM
bam-1791	148	7	main	main	ADJ
bam-1791	148	8	types	type	NOUN
bam-1791	148	9	of	of	ADP
bam-1791	148	10	macrophages	macrophage	NOUN
bam-1791	148	11	:	:	PUNCT
bam-1791	148	12	m1	m1	NOUN
bam-1791	148	13	(	(	PUNCT
bam-1791	148	14	pro	pro	ADJ
bam-1791	148	15	-	-	ADJ
bam-1791	148	16	inflammatory	inflammatory	ADJ
bam-1791	148	17	)	)	PUNCT
bam-1791	148	18	macrophages	macrophage	NOUN
bam-1791	148	19	,	,	PUNCT
bam-1791	148	20	that	that	PRON
bam-1791	148	21	can	can	AUX
bam-1791	148	22	stimulate	stimulate	VERB
bam-1791	148	23	proliferation	proliferation	NOUN
bam-1791	148	24	of	of	ADP
bam-1791	148	25	myoblasts	myoblast	NOUN
bam-1791	148	26	,	,	PUNCT
bam-1791	148	27	and	and	CCONJ
bam-1791	148	28	m2	m2	PROPN
bam-1791	148	29	(	(	PUNCT
bam-1791	148	30	anti	anti	ADJ
bam-1791	148	31	-	-	ADJ
bam-1791	148	32	inflammatory	inflammatory	ADJ
bam-1791	148	33	)	)	PUNCT
bam-1791	148	34	macrophages	macrophage	NOUN
bam-1791	148	35	,	,	PUNCT
bam-1791	148	36	which	which	PRON
bam-1791	148	37	can	can	AUX
bam-1791	148	38	stimulate	stimulate	VERB
bam-1791	148	39	the	the	DET
bam-1791	148	40	differentiation	differentiation	NOUN
bam-1791	148	41	of	of	ADP
bam-1791	148	42	myoblasts	myoblast	NOUN
bam-1791	148	43	.	.	PUNCT
bam-1791	149	1	inflammation	inflammation	NOUN
bam-1791	149	2	is	be	AUX
bam-1791	149	3	known	know	VERB
bam-1791	149	4	to	to	PART
bam-1791	149	5	play	play	VERB
bam-1791	149	6	a	a	DET
bam-1791	149	7	major	major	ADJ
bam-1791	149	8	role	role	NOUN
bam-1791	149	9	in	in	ADP
bam-1791	149	10	the	the	DET
bam-1791	149	11	pathophysiology	pathophysiology	NOUN
bam-1791	149	12	of	of	ADP
bam-1791	149	13	duchenne	duchenne	ADJ
bam-1791	149	14	muscular	muscular	ADJ
bam-1791	149	15	dystrophy	dystrophy	NOUN
bam-1791	149	16	.	.	PUNCT
bam-1791	150	1	to	to	PART
bam-1791	150	2	study	study	VERB
bam-1791	150	3	the	the	DET
bam-1791	150	4	effects	effect	NOUN
bam-1791	150	5	of	of	ADP
bam-1791	150	6	macrophage	macrophage	NOUN
bam-1791	150	7	-	-	PUNCT
bam-1791	150	8	released	release	VERB
bam-1791	150	9	factors	factor	NOUN
bam-1791	150	10	onto	onto	ADP
bam-1791	150	11	myogenic	myogenic	ADJ
bam-1791	150	12	cells	cell	NOUN
bam-1791	150	13	we	we	PRON
bam-1791	150	14	use	use	VERB
bam-1791	150	15	the	the	DET
bam-1791	150	16	murine	murine	ADJ
bam-1791	150	17	macrophage	macrophage	ADJ
bam-1791	150	18	cell	cell	NOUN
bam-1791	150	19	line	line	NOUN
bam-1791	150	20	j774	j774	PROPN
bam-1791	150	21	to	to	PART
bam-1791	150	22	obtain	obtain	VERB
bam-1791	150	23	a	a	DET
bam-1791	150	24	serum	serum	NOUN
bam-1791	150	25	-	-	PUNCT
bam-1791	150	26	free	free	ADJ
bam-1791	150	27	,	,	PUNCT
bam-1791	150	28	conditioned	condition	VERB
bam-1791	150	29	medium	medium	ADJ
bam-1791	150	30	(	(	PUNCT
bam-1791	150	31	mmcm	mmcm	NOUN
bam-1791	150	32	)	)	PUNCT
bam-1791	150	33	.	.	PUNCT
bam-1791	151	1	we	we	PRON
bam-1791	151	2	previously	previously	ADV
bam-1791	151	3	found	find	VERB
bam-1791	151	4	that	that	SCONJ
bam-1791	151	5	mmcm	mmcm	NOUN
bam-1791	151	6	enhance	enhance	VERB
bam-1791	151	7	the	the	DET
bam-1791	151	8	proliferation	proliferation	NOUN
bam-1791	151	9	rate	rate	NOUN
bam-1791	151	10	and	and	CCONJ
bam-1791	151	11	the	the	DET
bam-1791	151	12	differentiation	differentiation	NOUN
bam-1791	151	13	of	of	ADP
bam-1791	151	14	rat	rat	NOUN
bam-1791	151	15	and	and	CCONJ
bam-1791	151	16	both	both	CCONJ
bam-1791	151	17	normal	normal	ADJ
bam-1791	151	18	and	and	CCONJ
bam-1791	151	19	dystrophic	dystrophic	ADJ
bam-1791	151	20	human	human	ADJ
bam-1791	151	21	myoblasts	myoblast	NOUN
bam-1791	151	22	.	.	PUNCT
bam-1791	152	1	we	we	PRON
bam-1791	152	2	are	be	AUX
bam-1791	152	3	now	now	ADV
bam-1791	152	4	trying	try	VERB
bam-1791	152	5	to	to	PART
bam-1791	152	6	characterize	characterize	VERB
bam-1791	152	7	its	its	PRON
bam-1791	152	8	mechanism(s	mechanism(s	NOUN
bam-1791	152	9	)	)	PUNCT
bam-1791	152	10	of	of	ADP
bam-1791	152	11	action	action	NOUN
bam-1791	152	12	in	in	ADP
bam-1791	152	13	the	the	DET
bam-1791	152	14	murine	murine	ADJ
bam-1791	152	15	model	model	NOUN
bam-1791	152	16	.	.	PUNCT
bam-1791	153	1	we	we	PRON
bam-1791	153	2	confirmed	confirm	VERB
bam-1791	153	3	the	the	DET
bam-1791	153	4	pro	pro	ADJ
bam-1791	153	5	-	-	ADJ
bam-1791	153	6	proliferative	proliferative	ADJ
bam-1791	153	7	effect	effect	NOUN
bam-1791	153	8	of	of	ADP
bam-1791	153	9	mmcm	mmcm	NOUN
bam-1791	153	10	on	on	ADP
bam-1791	153	11	murine	murine	ADJ
bam-1791	153	12	satellite	satellite	NOUN
bam-1791	153	13	cells	cell	NOUN
bam-1791	153	14	but	but	CCONJ
bam-1791	153	15	we	we	PRON
bam-1791	153	16	found	find	VERB
bam-1791	153	17	that	that	SCONJ
bam-1791	153	18	mmcm	mmcm	NOUN
bam-1791	153	19	did	do	AUX
bam-1791	153	20	not	not	PART
bam-1791	153	21	have	have	VERB
bam-1791	153	22	any	any	DET
bam-1791	153	23	negative	negative	ADJ
bam-1791	153	24	effect	effect	NOUN
bam-1791	153	25	on	on	ADP
bam-1791	153	26	cell	cell	NOUN
bam-1791	153	27	fusion	fusion	NOUN
bam-1791	153	28	,	,	PUNCT
bam-1791	153	29	although	although	SCONJ
bam-1791	153	30	it	it	PRON
bam-1791	153	31	increased	increase	VERB
bam-1791	153	32	myod	myod	NOUN
bam-1791	153	33	expression	expression	NOUN
bam-1791	153	34	.	.	PUNCT
bam-1791	154	1	we	we	PRON
bam-1791	154	2	compared	compare	VERB
bam-1791	154	3	the	the	DET
bam-1791	154	4	effect	effect	NOUN
bam-1791	154	5	of	of	ADP
bam-1791	154	6	mmcm	mmcm	NOUN
bam-1791	154	7	on	on	ADP
bam-1791	154	8	satellite	satellite	NOUN
bam-1791	154	9	cells	cell	NOUN
bam-1791	154	10	to	to	ADP
bam-1791	154	11	that	that	PRON
bam-1791	154	12	of	of	ADP
bam-1791	154	13	macrophagic	macrophagic	ADJ
bam-1791	154	14	factors	factor	NOUN
bam-1791	154	15	released	release	VERB
bam-1791	154	16	by	by	ADP
bam-1791	154	17	m1	m1	PROPN
bam-1791	154	18	and	and	CCONJ
bam-1791	154	19	m2	m2	PROPN
bam-1791	154	20	human	human	ADJ
bam-1791	154	21	macrophages	macrophage	NOUN
bam-1791	154	22	.	.	PUNCT
bam-1791	155	1	m1	m1	PROPN
bam-1791	155	2	conditioned	condition	VERB
bam-1791	155	3	medium	medium	NOUN
bam-1791	155	4	showed	show	VERB
bam-1791	155	5	a	a	DET
bam-1791	155	6	pro	pro	ADJ
bam-1791	155	7	-	-	ADJ
bam-1791	155	8	proliferative	proliferative	ADJ
bam-1791	155	9	effect	effect	NOUN
bam-1791	155	10	similar	similar	ADJ
bam-1791	155	11	to	to	ADP
bam-1791	155	12	mmcm	mmcm	NOUN
bam-1791	155	13	,	,	PUNCT
bam-1791	155	14	whereas	whereas	SCONJ
bam-1791	155	15	m2	m2	PROPN
bam-1791	155	16	conditioned	condition	VERB
bam-1791	155	17	medium	medium	NOUN
bam-1791	155	18	appeared	appear	VERB
bam-1791	155	19	to	to	PART
bam-1791	155	20	have	have	VERB
bam-1791	155	21	an	an	DET
bam-1791	155	22	anti	anti	ADJ
bam-1791	155	23	-	-	ADJ
bam-1791	155	24	proliferative	proliferative	ADJ
bam-1791	155	25	effect	effect	NOUN
bam-1791	155	26	.	.	PUNCT
bam-1791	156	1	we	we	PRON
bam-1791	156	2	also	also	ADV
bam-1791	156	3	found	find	VERB
bam-1791	156	4	that	that	SCONJ
bam-1791	156	5	mmcm	mmcm	NOUN
bam-1791	156	6	consistently	consistently	ADV
bam-1791	156	7	has	have	VERB
bam-1791	156	8	a	a	DET
bam-1791	156	9	clear	clear	ADJ
bam-1791	156	10	anti	anti	ADJ
bam-1791	156	11	-	-	ADJ
bam-1791	156	12	proliferative	proliferative	ADJ
bam-1791	156	13	effect	effect	NOUN
bam-1791	156	14	on	on	ADP
bam-1791	156	15	primary	primary	ADJ
bam-1791	156	16	mdx	mdx	NOUN
bam-1791	156	17	fibroblasts	fibroblast	NOUN
bam-1791	156	18	.	.	PUNCT
bam-1791	157	1	a	a	DET
bam-1791	157	2	preliminary	preliminary	ADJ
bam-1791	157	3	experiment	experiment	NOUN
bam-1791	157	4	on	on	ADP
bam-1791	157	5	the	the	DET
bam-1791	157	6	effect	effect	NOUN
bam-1791	157	7	of	of	ADP
bam-1791	157	8	on	on	ADP
bam-1791	157	9	satellite	satellite	NOUN
bam-1791	157	10	cell	cell	NOUN
bam-1791	157	11	transplantation	transplantation	NOUN
bam-1791	157	12	in	in	ADP
bam-1791	157	13	dystrophic	dystrophic	ADJ
bam-1791	157	14	muscle	muscle	NOUN
bam-1791	157	15	was	be	AUX
bam-1791	157	16	carried	carry	VERB
bam-1791	157	17	out	out	ADP
bam-1791	157	18	,	,	PUNCT
bam-1791	157	19	finding	find	VERB
bam-1791	157	20	that	that	SCONJ
bam-1791	157	21	apparently	apparently	ADV
bam-1791	157	22	mmcm	mmcm	NOUN
bam-1791	157	23	led	lead	VERB
bam-1791	157	24	to	to	ADP
bam-1791	157	25	much	much	ADV
bam-1791	157	26	better	well	ADJ
bam-1791	157	27	grafting	grafting	NOUN
bam-1791	157	28	.	.	PUNCT
bam-1791	158	1	finally	finally	ADV
bam-1791	158	2	,	,	PUNCT
bam-1791	158	3	we	we	PRON
bam-1791	158	4	investigated	investigate	VERB
bam-1791	158	5	the	the	DET
bam-1791	158	6	effects	effect	NOUN
bam-1791	158	7	of	of	ADP
bam-1791	158	8	mmcm	mmcm	NOUN
bam-1791	158	9	on	on	ADP
bam-1791	158	10	macrophages	macrophage	NOUN
bam-1791	158	11	polarization	polarization	NOUN
bam-1791	158	12	,	,	PUNCT
bam-1791	158	13	using	use	VERB
bam-1791	158	14	human	human	ADJ
bam-1791	158	15	monocytes	monocyte	NOUN
bam-1791	158	16	from	from	ADP
bam-1791	158	17	blood	blood	NOUN
bam-1791	158	18	that	that	PRON
bam-1791	158	19	were	be	AUX
bam-1791	158	20	differentiated	differentiate	VERB
bam-1791	158	21	and	and	CCONJ
bam-1791	158	22	then	then	ADV
bam-1791	158	23	stimulated	stimulate	VERB
bam-1791	158	24	to	to	PART
bam-1791	158	25	acquire	acquire	VERB
bam-1791	158	26	either	either	CCONJ
bam-1791	158	27	m1	m1	PROPN
bam-1791	158	28	or	or	CCONJ
bam-1791	158	29	m2	m2	PROPN
bam-1791	158	30	phenotype	phenotype	NOUN
bam-1791	158	31	.	.	PUNCT
bam-1791	159	1	preliminary	preliminary	ADJ
bam-1791	159	2	results	result	NOUN
bam-1791	159	3	showed	show	VERB
bam-1791	159	4	that	that	SCONJ
bam-1791	159	5	mmcm	mmcm	NOUN
bam-1791	159	6	might	might	AUX
bam-1791	159	7	push	push	VERB
bam-1791	159	8	them	they	PRON
bam-1791	159	9	towards	towards	ADP
bam-1791	159	10	the	the	DET
bam-1791	159	11	m2	m2	PROPN
bam-1791	159	12	anti	anti	ADJ
bam-1791	159	13	-	-	ADJ
bam-1791	159	14	inflammatory	inflammatory	ADJ
bam-1791	159	15	phenotype	phenotype	NOUN
bam-1791	159	16	.	.	PUNCT
bam-1791	160	1	session	session	NOUN
bam-1791	160	2	3	3	NUM
bam-1791	160	3	muscular	muscular	ADJ
bam-1791	160	4	dystrophies	dystrophy	NOUN
bam-1791	160	5	14	14	NUM
bam-1791	160	6	.	.	PUNCT
bam-1791	161	1	the	the	DET
bam-1791	161	2	rag2	rag2	PROPN
bam-1791	161	3	–	–	PUNCT
bam-1791	161	4	il2rb	il2rb	PROPN
bam-1791	161	5	–	–	PUNCT
bam-1791	161	6	dmd	dmd	NOUN
bam-1791	161	7	–	–	PUNCT
bam-1791	161	8	mouse	mouse	NOUN
bam-1791	161	9	:	:	PUNCT
bam-1791	161	10	a	a	DET
bam-1791	161	11	novel	novel	ADJ
bam-1791	161	12	model	model	NOUN
bam-1791	161	13	to	to	PART
bam-1791	161	14	assess	assess	VERB
bam-1791	161	15	celland	celland	NOUN
bam-1791	161	16	gene	gene	NOUN
bam-1791	161	17	-	-	PUNCT
bam-1791	161	18	therapy	therapy	NOUN
bam-1791	161	19	strategies	strategy	NOUN
bam-1791	161	20	for	for	ADP
bam-1791	161	21	muscular	muscular	ADJ
bam-1791	161	22	dystrophies	dystrophy	NOUN
bam-1791	161	23	.	.	PUNCT
bam-1791	162	1	vallese	vallese	NOUN
bam-1791	162	2	denis1,2,3,4	denis1,2,3,4	ADJ
bam-1791	162	3	,	,	PUNCT
bam-1791	162	4	negroni	negroni	NOUN
bam-1791	162	5	elisa1,2,3	elisa1,2,3	PROPN
bam-1791	162	6	,	,	PUNCT
bam-1791	162	7	ferry	ferry	NOUN
bam-1791	162	8	arnaud1,2,3	arnaud1,2,3	ADJ
bam-1791	162	9	,	,	PUNCT
bam-1791	162	10	aamiri	aamiri	NOUN
bam-1791	162	11	ahmed5	ahmed5	VERB
bam-1791	162	12	,	,	PUNCT
bam-1791	162	13	di	di	X
bam-1791	162	14	santo	santo	PROPN
bam-1791	162	15	james6	james6	PROPN
bam-1791	162	16	,	,	PUNCT
bam-1791	162	17	vitiello	vitiello	ADP
bam-1791	162	18	libero4	libero4	PROPN
bam-1791	162	19	,	,	PUNCT
bam-1791	162	20	mouly	mouly	ADV
bam-1791	162	21	vincent1,2,3	vincent1,2,3	PROPN
bam-1791	162	22	&	&	CCONJ
bam-1791	162	23	butler	butler	PROPN
bam-1791	162	24	-	-	PUNCT
bam-1791	162	25	browne	browne	PROPN
bam-1791	162	26	gillian1,2,3	gillian1,2,3	NOUN
bam-1791	162	27	.	.	PUNCT
bam-1791	163	1	1	1	NUM
bam-1791	163	2	upmc	upmc	PROPN
bam-1791	163	3	université	université	PROPN
bam-1791	163	4	paris	paris	PROPN
bam-1791	163	5	6	6	NUM
bam-1791	163	6	,	,	PUNCT
bam-1791	163	7	um76	um76	PROPN
bam-1791	163	8	,	,	PUNCT
bam-1791	163	9	institut	institut	PROPN
bam-1791	163	10	de	de	PROPN
bam-1791	163	11	myologie	myologie	PROPN
bam-1791	163	12	,	,	PUNCT
bam-1791	163	13	47	47	NUM
bam-1791	163	14	bd	bd	PROPN
bam-1791	163	15	de	de	PROPN
bam-1791	163	16	l’hôpital	l’hôpital	PROPN
bam-1791	163	17	,	,	PUNCT
bam-1791	163	18	75651	75651	NUM
bam-1791	163	19	paris	paris	PROPN
bam-1791	163	20	,	,	PUNCT
bam-1791	163	21	france	france	PROPN
bam-1791	163	22	.	.	PUNCT
bam-1791	163	23	2	2	NUM
bam-1791	163	24	inserm	inserm	NOUN
bam-1791	163	25	u	u	NOUN
bam-1791	163	26	974	974	NUM
bam-1791	163	27	,	,	PUNCT
bam-1791	163	28	institut	institut	PROPN
bam-1791	163	29	de	de	PROPN
bam-1791	163	30	myologie	myologie	PROPN
bam-1791	163	31	,	,	PUNCT
bam-1791	163	32	paris	paris	PROPN
bam-1791	163	33	,	,	PUNCT
bam-1791	163	34	france	france	PROPN
bam-1791	163	35	.	.	PUNCT
bam-1791	163	36	3	3	NUM
bam-1791	163	37	cnrs	cnrs	NOUN
bam-1791	163	38	umr	umr	PROPN
bam-1791	163	39	7215	7215	NUM
bam-1791	163	40	,	,	PUNCT
bam-1791	163	41	institut	institut	PROPN
bam-1791	163	42	de	de	PROPN
bam-1791	163	43	myologie	myologie	PROPN
bam-1791	163	44	,	,	PUNCT
bam-1791	163	45	paris	paris	PROPN
bam-1791	163	46	,	,	PUNCT
bam-1791	163	47	france	france	PROPN
bam-1791	163	48	.	.	PROPN
bam-1791	163	49	4	4	NUM
bam-1791	163	50	department	department	NOUN
bam-1791	163	51	of	of	ADP
bam-1791	163	52	biology	biology	NOUN
bam-1791	163	53	,	,	PUNCT
bam-1791	163	54	university	university	PROPN
bam-1791	163	55	of	of	ADP
bam-1791	163	56	padova	padova	PROPN
bam-1791	163	57	,	,	PUNCT
bam-1791	163	58	italy	italy	PROPN
bam-1791	163	59	.	.	PROPN
bam-1791	163	60	5	5	NUM
bam-1791	163	61	laboratoire	laboratoire	PROPN
bam-1791	163	62	de	de	X
bam-1791	163	63	biologie	biologie	PROPN
bam-1791	163	64	cellulaire	cellulaire	PROPN
bam-1791	163	65	et	et	NOUN
bam-1791	163	66	moléculaire	moléculaire	NOUN
bam-1791	163	67	,	,	PUNCT
bam-1791	163	68	faculté	faculté	PROPN
bam-1791	163	69	des	des	PROPN
bam-1791	163	70	sciences	sciences	PROPN
bam-1791	163	71	,	,	PUNCT
bam-1791	163	72	université	université	NOUN
bam-1791	163	73	ibn	ibn	PROPN
bam-1791	163	74	zohr	zohr	NOUN
bam-1791	163	75	.	.	PUNCT
bam-1791	164	1	agadirmaroc	agadirmaroc	NOUN
bam-1791	164	2	6	6	NUM
bam-1791	164	3	cytokines	cytokine	NOUN
bam-1791	164	4	and	and	CCONJ
bam-1791	164	5	lymphoid	lymphoid	ADJ
bam-1791	164	6	development	development	NOUN
bam-1791	164	7	unit	unit	NOUN
bam-1791	164	8	,	,	PUNCT
bam-1791	164	9	inserm	inserm	VERB
bam-1791	164	10	u	u	NOUN
bam-1791	164	11	668	668	NUM
bam-1791	164	12	,	,	PUNCT
bam-1791	164	13	institut	institut	PROPN
bam-1791	164	14	pasteur	pasteur	PROPN
bam-1791	164	15	,	,	PUNCT
bam-1791	164	16	paris	paris	PROPN
bam-1791	164	17	,	,	PUNCT
bam-1791	164	18	france	france	PROPN
bam-1791	164	19	cell	cell	NOUN
bam-1791	164	20	transplantation	transplantation	NOUN
bam-1791	164	21	is	be	AUX
bam-1791	164	22	considered	consider	VERB
bam-1791	164	23	as	as	ADP
bam-1791	164	24	a	a	DET
bam-1791	164	25	potential	potential	ADJ
bam-1791	164	26	therapeutic	therapeutic	ADJ
bam-1791	164	27	approach	approach	NOUN
bam-1791	164	28	to	to	ADP
bam-1791	164	29	muscular	muscular	ADJ
bam-1791	164	30	dystrophies	dystrophy	NOUN
bam-1791	164	31	,	,	PUNCT
bam-1791	164	32	however	however	ADV
bam-1791	164	33	,	,	PUNCT
bam-1791	164	34	it	it	PRON
bam-1791	164	35	still	still	ADV
bam-1791	164	36	requires	require	VERB
bam-1791	164	37	deeper	deep	ADJ
bam-1791	164	38	insights	insight	NOUN
bam-1791	164	39	into	into	ADP
bam-1791	164	40	the	the	DET
bam-1791	164	41	in	in	ADJ
bam-1791	164	42	vivo	vivo	NOUN
bam-1791	164	43	behaviour	behaviour	NOUN
bam-1791	164	44	of	of	ADP
bam-1791	164	45	transplanted	transplanted	ADJ
bam-1791	164	46	human	human	ADJ
bam-1791	164	47	myogenic	myogenic	ADJ
bam-1791	164	48	cells	cell	NOUN
bam-1791	164	49	,	,	PUNCT
bam-1791	164	50	for	for	ADP
bam-1791	164	51	which	which	PRON
bam-1791	164	52	an	an	DET
bam-1791	164	53	optimized	optimize	VERB
bam-1791	164	54	model	model	NOUN
bam-1791	164	55	would	would	AUX
bam-1791	164	56	be	be	AUX
bam-1791	164	57	immunodeficient	immunodeficient	NOUN
bam-1791	164	58	and	and	CCONJ
bam-1791	164	59	dystrophic	dystrophic	ADJ
bam-1791	164	60	.	.	PUNCT
bam-1791	165	1	this	this	DET
bam-1791	165	2	study	study	NOUN
bam-1791	165	3	focuses	focus	VERB
bam-1791	165	4	on	on	ADP
bam-1791	165	5	the	the	DET
bam-1791	165	6	characterization	characterization	NOUN
bam-1791	165	7	of	of	ADP
bam-1791	165	8	a	a	DET
bam-1791	165	9	new	new	ADJ
bam-1791	165	10	immunodeficient	immunodeficient	NOUN
bam-1791	165	11	and	and	CCONJ
bam-1791	165	12	dystrophic	dystrophic	ADJ
bam-1791	165	13	rag2	rag2	PROPN
bam-1791	165	14	–	–	PUNCT
bam-1791	165	15	il2rb	il2rb	PROPN
bam-1791	165	16	–	–	PUNCT
bam-1791	165	17	dmd	dmd	NOUN
bam-1791	165	18	–	–	PUNCT
bam-1791	165	19	mouse	mouse	NOUN
bam-1791	165	20	model	model	NOUN
bam-1791	165	21	that	that	PRON
bam-1791	165	22	we	we	PRON
bam-1791	165	23	have	have	AUX
bam-1791	165	24	recently	recently	ADV
bam-1791	165	25	developed	develop	VERB
bam-1791	165	26	.	.	PUNCT
bam-1791	166	1	methods	method	NOUN
bam-1791	166	2	we	we	PRON
bam-1791	166	3	measured	measure	VERB
bam-1791	166	4	the	the	DET
bam-1791	166	5	whole	whole	ADJ
bam-1791	166	6	body	body	NOUN
bam-1791	166	7	weight	weight	NOUN
bam-1791	166	8	and	and	CCONJ
bam-1791	166	9	the	the	DET
bam-1791	166	10	weight	weight	NOUN
bam-1791	166	11	of	of	ADP
bam-1791	166	12	different	different	ADJ
bam-1791	166	13	leg	leg	NOUN
bam-1791	166	14	muscles	muscle	NOUN
bam-1791	166	15	.	.	PUNCT
bam-1791	167	1	we	we	PRON
bam-1791	167	2	measured	measure	VERB
bam-1791	167	3	the	the	DET
bam-1791	167	4	serum	serum	NOUN
bam-1791	167	5	levels	level	NOUN
bam-1791	167	6	of	of	ADP
bam-1791	167	7	creatine	creatine	PROPN
bam-1791	167	8	kinase	kinase	PROPN
bam-1791	167	9	(	(	PUNCT
bam-1791	167	10	ck	ck	PROPN
bam-1791	167	11	)	)	PUNCT
bam-1791	167	12	,	,	PUNCT
bam-1791	167	13	and	and	CCONJ
bam-1791	167	14	the	the	DET
bam-1791	167	15	regeneration	regeneration	NOUN
bam-1791	167	16	process	process	NOUN
bam-1791	167	17	was	be	AUX
bam-1791	167	18	quantified	quantify	VERB
bam-1791	167	19	by	by	ADP
bam-1791	167	20	immunohistochemical	immunohistochemical	ADJ
bam-1791	167	21	analysis	analysis	NOUN
bam-1791	167	22	of	of	ADP
bam-1791	167	23	neonatal	neonatal	ADJ
bam-1791	167	24	myosin	myosin	PROPN
bam-1791	167	25	heavy	heavy	ADJ
bam-1791	167	26	chain	chain	NOUN
bam-1791	167	27	.	.	PUNCT
bam-1791	168	1	we	we	PRON
bam-1791	168	2	also	also	ADV
bam-1791	168	3	performed	perform	VERB
bam-1791	168	4	physiology	physiology	NOUN
bam-1791	168	5	tests	test	NOUN
bam-1791	168	6	and	and	CCONJ
bam-1791	168	7	assessed	assess	VERB
bam-1791	168	8	the	the	DET
bam-1791	168	9	feasibility	feasibility	NOUN
bam-1791	168	10	of	of	ADP
bam-1791	168	11	injecting	inject	VERB
bam-1791	168	12	human	human	ADJ
bam-1791	168	13	myoblasts	myoblast	NOUN
bam-1791	168	14	.	.	PUNCT
bam-1791	169	1	ix	ix	PROPN
bam-1791	169	2	iim	iim	PROPN
bam-1791	169	3	meeting	meeting	NOUN
bam-1791	169	4	,	,	PUNCT
bam-1791	169	5	acaya	acaya	NOUN
bam-1791	169	6	(	(	PUNCT
bam-1791	169	7	lecce	lecce	PROPN
bam-1791	169	8	)	)	PUNCT
bam-1791	169	9	,	,	PUNCT
bam-1791	169	10	october	october	PROPN
bam-1791	169	11	12	12	NUM
bam-1791	169	12	-	-	SYM
bam-1791	169	13	14	14	NUM
bam-1791	169	14	,	,	PUNCT
bam-1791	169	15	2012	2012	NUM
bam-1791	169	16	european	european	PROPN
bam-1791	169	17	journal	journal	PROPN
bam-1791	169	18	translational	translational	ADJ
bam-1791	169	19	myology	myology	NOUN
bam-1791	169	20	basic	basic	ADJ
bam-1791	169	21	applied	apply	VERB
bam-1791	169	22	myology	myology	NOUN
bam-1791	169	23	2012	2012	NUM
bam-1791	169	24	;	;	PUNCT
bam-1791	169	25	22(1&2	22(1&2	NUM
bam-1791	169	26	):	):	PUNCT
bam-1791	169	27	xxx	xxx	NOUN
bam-1791	169	28	-	-	PUNCT
bam-1791	169	29	xxx	xxx	NOUN
bam-1791	169	30	26	26	NUM
bam-1791	169	31	this	this	DET
bam-1791	169	32	dystrophic	dystrophic	ADJ
bam-1791	169	33	model	model	NOUN
bam-1791	169	34	showed	show	VERB
bam-1791	169	35	growth	growth	NOUN
bam-1791	169	36	curves	curve	NOUN
bam-1791	169	37	similar	similar	ADJ
bam-1791	169	38	to	to	ADP
bam-1791	169	39	mdx	mdx	PROPN
bam-1791	169	40	(	(	PUNCT
bam-1791	169	41	total	total	ADJ
bam-1791	169	42	body	body	NOUN
bam-1791	169	43	and	and	CCONJ
bam-1791	169	44	single	single	ADJ
bam-1791	169	45	muscles	muscle	NOUN
bam-1791	169	46	weight	weight	NOUN
bam-1791	169	47	)	)	PUNCT
bam-1791	169	48	.	.	PUNCT
bam-1791	170	1	in	in	ADP
bam-1791	170	2	mdx	mdx	PROPN
bam-1791	170	3	mice	mouse	NOUN
bam-1791	170	4	,	,	PUNCT
bam-1791	170	5	ck	ck	PROPN
bam-1791	170	6	levels	level	NOUN
bam-1791	170	7	showed	show	VERB
bam-1791	170	8	a	a	DET
bam-1791	170	9	significant	significant	ADJ
bam-1791	170	10	decrease	decrease	NOUN
bam-1791	170	11	between	between	ADP
bam-1791	170	12	8	8	NUM
bam-1791	170	13	and	and	CCONJ
bam-1791	170	14	24/40	24/40	NUM
bam-1791	170	15	weeks	week	NOUN
bam-1791	170	16	of	of	ADP
bam-1791	170	17	age	age	NOUN
bam-1791	170	18	,	,	PUNCT
bam-1791	170	19	whereas	whereas	SCONJ
bam-1791	170	20	rag2	rag2	PROPN
bam-1791	170	21	–	–	PUNCT
bam-1791	170	22	il2rb	il2rb	PROPN
bam-1791	170	23	–	–	PUNCT
bam-1791	170	24	dmd	dmd	NOUN
bam-1791	170	25	–	–	PUNCT
bam-1791	170	26	showed	show	VERB
bam-1791	170	27	an	an	DET
bam-1791	170	28	opposite	opposite	ADJ
bam-1791	170	29	trend	trend	NOUN
bam-1791	170	30	.	.	PUNCT
bam-1791	171	1	rag2	rag2	PROPN
bam-1791	171	2	–	–	PUNCT
bam-1791	171	3	il2rb	il2rb	PROPN
bam-1791	171	4	–	–	PUNCT
bam-1791	171	5	dmd	dmd	NOUN
bam-1791	171	6	–	–	PUNCT
bam-1791	171	7	animals	animal	NOUN
bam-1791	171	8	present	present	VERB
bam-1791	171	9	a	a	DET
bam-1791	171	10	wider	wide	ADJ
bam-1791	171	11	and	and	CCONJ
bam-1791	171	12	delayed	delay	VERB
bam-1791	171	13	regeneration	regeneration	NOUN
bam-1791	171	14	peak	peak	NOUN
bam-1791	171	15	,	,	PUNCT
bam-1791	171	16	which	which	PRON
bam-1791	171	17	started	start	VERB
bam-1791	171	18	between	between	ADP
bam-1791	171	19	10	10	NUM
bam-1791	171	20	and	and	CCONJ
bam-1791	171	21	16	16	NUM
bam-1791	171	22	weeks	week	NOUN
bam-1791	171	23	of	of	ADP
bam-1791	171	24	age	age	NOUN
bam-1791	171	25	.	.	PUNCT
bam-1791	172	1	both	both	DET
bam-1791	172	2	dystrophic	dystrophic	ADJ
bam-1791	172	3	models	model	NOUN
bam-1791	172	4	presented	present	VERB
bam-1791	172	5	similar	similar	ADJ
bam-1791	172	6	decreases	decrease	NOUN
bam-1791	172	7	in	in	ADP
bam-1791	172	8	the	the	DET
bam-1791	172	9	specific	specific	ADJ
bam-1791	172	10	force	force	NOUN
bam-1791	172	11	.	.	PUNCT
bam-1791	173	1	transplantation	transplantation	NOUN
bam-1791	173	2	of	of	ADP
bam-1791	173	3	human	human	ADJ
bam-1791	173	4	myoblasts	myoblast	NOUN
bam-1791	173	5	were	be	AUX
bam-1791	173	6	successful	successful	ADJ
bam-1791	173	7	in	in	ADP
bam-1791	173	8	rag2	rag2	PROPN
bam-1791	173	9	–	–	PUNCT
bam-1791	173	10	il2rb	il2rb	PROPN
bam-1791	173	11	–	–	PUNCT
bam-1791	173	12	dmd	dmd	NOUN
bam-1791	173	13	–	–	PUNCT
bam-1791	173	14	animals	animal	NOUN
bam-1791	173	15	.	.	PUNCT
bam-1791	174	1	the	the	DET
bam-1791	174	2	muscular	muscular	ADJ
bam-1791	174	3	phenotype	phenotype	NOUN
bam-1791	174	4	of	of	ADP
bam-1791	174	5	this	this	DET
bam-1791	174	6	new	new	ADJ
bam-1791	174	7	mouse	mouse	NOUN
bam-1791	174	8	model	model	NOUN
bam-1791	174	9	clearly	clearly	ADV
bam-1791	174	10	resembles	resemble	VERB
bam-1791	174	11	that	that	PRON
bam-1791	174	12	of	of	ADP
bam-1791	174	13	the	the	DET
bam-1791	174	14	mdx	mdx	NOUN
bam-1791	174	15	model	model	NOUN
bam-1791	174	16	,	,	PUNCT
bam-1791	174	17	and	and	CCONJ
bam-1791	174	18	therefore	therefore	ADV
bam-1791	174	19	constitutes	constitute	VERB
bam-1791	174	20	a	a	DET
bam-1791	174	21	useful	useful	ADJ
bam-1791	174	22	tool	tool	NOUN
bam-1791	174	23	that	that	PRON
bam-1791	174	24	can	can	AUX
bam-1791	174	25	be	be	AUX
bam-1791	174	26	used	use	VERB
bam-1791	174	27	for	for	ADP
bam-1791	174	28	assessing	assess	VERB
bam-1791	174	29	gene	gene	NOUN
bam-1791	174	30	and	and	CCONJ
bam-1791	174	31	cell	cell	NOUN
bam-1791	174	32	therapy	therapy	NOUN
bam-1791	174	33	approaches	approach	VERB
bam-1791	174	34	,	,	PUNCT
bam-1791	174	35	particularly	particularly	ADV
bam-1791	174	36	using	use	VERB
bam-1791	174	37	human	human	ADJ
bam-1791	174	38	myogenic	myogenic	ADJ
bam-1791	174	39	stem	stem	NOUN
bam-1791	174	40	cells	cell	NOUN
bam-1791	174	41	.	.	PUNCT
bam-1791	175	1	15	15	NUM
bam-1791	175	2	.	.	X
bam-1791	175	3	muscle	muscle	NOUN
bam-1791	175	4	expression	expression	NOUN
bam-1791	175	5	of	of	ADP
bam-1791	175	6	pgc1α	pgc1α	PROPN
bam-1791	175	7	and	and	CCONJ
bam-1791	175	8	related	related	ADJ
bam-1791	175	9	signalling	signal	VERB
bam-1791	175	10	molecules	molecule	NOUN
bam-1791	175	11	in	in	ADP
bam-1791	175	12	the	the	DET
bam-1791	175	13	mdx	mdx	NOUN
bam-1791	175	14	mouse	mouse	NOUN
bam-1791	175	15	:	:	PUNCT
bam-1791	175	16	identification	identification	NOUN
bam-1791	175	17	of	of	ADP
bam-1791	175	18	altered	altered	ADJ
bam-1791	175	19	pathways	pathway	NOUN
bam-1791	175	20	in	in	ADP
bam-1791	175	21	mechano	mechano	PROPN
bam-1791	175	22	-	-	PUNCT
bam-1791	175	23	transduction	transduction	NOUN
bam-1791	175	24	and	and	CCONJ
bam-1791	175	25	of	of	ADP
bam-1791	175	26	novel	novel	ADJ
bam-1791	175	27	drug	drug	NOUN
bam-1791	175	28	targets	target	NOUN
bam-1791	175	29	.	.	PUNCT
bam-1791	176	1	camerino	camerino	NOUN
bam-1791	176	2	g.m.(1	g.m.(1	NUM
bam-1791	176	3	)	)	PUNCT
bam-1791	176	4	,	,	PUNCT
bam-1791	176	5	cannone	cannone	NOUN
bam-1791	176	6	m.	m.	NOUN
bam-1791	176	7	(	(	PUNCT
bam-1791	176	8	1	1	NUM
bam-1791	176	9	)	)	PUNCT
bam-1791	176	10	,	,	PUNCT
bam-1791	176	11	capogrosso	capogrosso	NOUN
bam-1791	176	12	r.f	r.f	PROPN
bam-1791	176	13	.	.	PUNCT
bam-1791	177	1	(	(	PUNCT
bam-1791	177	2	1	1	NUM
bam-1791	177	3	)	)	PUNCT
bam-1791	177	4	,	,	PUNCT
bam-1791	177	5	cozzoli	cozzoli	NOUN
bam-1791	177	6	a.(1	a.(1	PROPN
bam-1791	177	7	)	)	PUNCT
bam-1791	177	8	,	,	PUNCT
bam-1791	177	9	de	de	X
bam-1791	177	10	luca	luca	PROPN
bam-1791	177	11	,	,	PUNCT
bam-1791	177	12	a	a	DET
bam-1791	177	13	(	(	PUNCT
bam-1791	177	14	1	1	NUM
bam-1791	177	15	)	)	PUNCT
bam-1791	177	16	.	.	PUNCT
bam-1791	178	1	(	(	PUNCT
bam-1791	178	2	1)university	1)university	NUM
bam-1791	178	3	of	of	ADP
bam-1791	178	4	bari	bari	NOUN
bam-1791	178	5	,	,	PUNCT
bam-1791	178	6	unit	unit	NOUN
bam-1791	178	7	of	of	ADP
bam-1791	178	8	pharmacology	pharmacology	NOUN
bam-1791	178	9	,	,	PUNCT
bam-1791	178	10	department	department	NOUN
bam-1791	178	11	of	of	ADP
bam-1791	178	12	pharmacy	pharmacy	NOUN
bam-1791	178	13	,	,	PUNCT
bam-1791	178	14	bari	bari	NOUN
bam-1791	178	15	,	,	PUNCT
bam-1791	178	16	italy	italy	PROPN
bam-1791	178	17	in	in	ADP
bam-1791	178	18	duchenne	duchenne	PROPN
bam-1791	178	19	muscular	muscular	ADJ
bam-1791	178	20	dystrophy	dystrophy	NOUN
bam-1791	178	21	(	(	PUNCT
bam-1791	178	22	dmd	dmd	NOUN
bam-1791	178	23	)	)	PUNCT
bam-1791	178	24	,	,	PUNCT
bam-1791	178	25	the	the	DET
bam-1791	178	26	absence	absence	NOUN
bam-1791	178	27	of	of	ADP
bam-1791	178	28	dystrophin	dystrophin	NOUN
bam-1791	178	29	causes	cause	VERB
bam-1791	178	30	a	a	DET
bam-1791	178	31	complex	complex	ADJ
bam-1791	178	32	pathogenetic	pathogenetic	ADJ
bam-1791	178	33	cascade	cascade	NOUN
bam-1791	178	34	also	also	ADV
bam-1791	178	35	involving	involve	VERB
bam-1791	178	36	sarcolemmal	sarcolemmal	ADJ
bam-1791	178	37	fragility	fragility	NOUN
bam-1791	178	38	and	and	CCONJ
bam-1791	178	39	metabolic	metabolic	NOUN
bam-1791	178	40	distress	distress	NOUN
bam-1791	178	41	.	.	PUNCT
bam-1791	179	1	increasing	increase	VERB
bam-1791	179	2	evidences	evidence	NOUN
bam-1791	179	3	in	in	ADP
bam-1791	179	4	mdx	mdx	PROPN
bam-1791	179	5	mouse	mouse	PROPN
bam-1791	179	6	model	model	PROPN
bam-1791	179	7	outline	outline	VERB
bam-1791	179	8	the	the	DET
bam-1791	179	9	potential	potential	ADJ
bam-1791	179	10	benefit	benefit	NOUN
bam-1791	179	11	in	in	ADP
bam-1791	179	12	reinforcing	reinforce	VERB
bam-1791	179	13	pathways	pathway	NOUN
bam-1791	179	14	of	of	ADP
bam-1791	179	15	peroxisome	peroxisome	NOUN
bam-1791	179	16	proliferator	proliferator	NOUN
bam-1791	179	17	-	-	PUNCT
bam-1791	179	18	activated	activate	VERB
bam-1791	179	19	receptor	receptor	NOUN
bam-1791	179	20	(	(	PUNCT
bam-1791	179	21	ppar)γ	ppar)γ	ADJ
bam-1791	179	22	coactivator	coactivator	NOUN
bam-1791	179	23	1α	1α	NUM
bam-1791	179	24	(	(	PUNCT
bam-1791	179	25	pgc1α	pgc1α	PROPN
bam-1791	179	26	)	)	PUNCT
bam-1791	179	27	,	,	PUNCT
bam-1791	179	28	a	a	DET
bam-1791	179	29	key	key	ADJ
bam-1791	179	30	modulator	modulator	NOUN
bam-1791	179	31	of	of	ADP
bam-1791	179	32	oxidative	oxidative	ADJ
bam-1791	179	33	metabolism	metabolism	NOUN
bam-1791	179	34	.	.	PUNCT
bam-1791	180	1	accordingly	accordingly	ADV
bam-1791	180	2	,	,	PUNCT
bam-1791	180	3	we	we	PRON
bam-1791	180	4	found	find	VERB
bam-1791	180	5	beneficial	beneficial	ADJ
bam-1791	180	6	effects	effect	NOUN
bam-1791	180	7	of	of	ADP
bam-1791	180	8	resveratrol	resveratrol	NOUN
bam-1791	180	9	,	,	PUNCT
bam-1791	180	10	a	a	DET
bam-1791	180	11	pgc1α	pgc1α	PROPN
bam-1791	180	12	activator	activator	NOUN
bam-1791	180	13	via	via	ADP
bam-1791	180	14	sirtuin1	sirtuin1	ADJ
bam-1791	180	15	(	(	PUNCT
bam-1791	180	16	sirt1	sirt1	NOUN
bam-1791	180	17	)	)	PUNCT
bam-1791	180	18	,	,	PUNCT
bam-1791	180	19	in	in	ADP
bam-1791	180	20	exercised	exercise	VERB
bam-1791	180	21	mdx	mdx	NOUN
bam-1791	180	22	mice	mouse	NOUN
bam-1791	180	23	.	.	PUNCT
bam-1791	181	1	to	to	PART
bam-1791	181	2	better	well	ADV
bam-1791	181	3	understand	understand	VERB
bam-1791	181	4	the	the	DET
bam-1791	181	5	basal	basal	ADJ
bam-1791	181	6	regulation	regulation	NOUN
bam-1791	181	7	of	of	ADP
bam-1791	181	8	this	this	DET
bam-1791	181	9	mechano	mechano	PROPN
bam-1791	181	10	-	-	ADJ
bam-1791	181	11	sensitive	sensitive	ADJ
bam-1791	181	12	pathway	pathway	NOUN
bam-1791	181	13	in	in	ADP
bam-1791	181	14	dystrophic	dystrophic	ADJ
bam-1791	181	15	skeletal	skeletal	ADJ
bam-1791	181	16	muscle	muscle	NOUN
bam-1791	181	17	we	we	PRON
bam-1791	181	18	performed	perform	VERB
bam-1791	181	19	realtime	realtime	ADJ
bam-1791	181	20	-	-	PUNCT
bam-1791	181	21	pcr	pcr	ADJ
bam-1791	181	22	experiments	experiment	NOUN
bam-1791	181	23	in	in	ADP
bam-1791	181	24	gastrocnemius	gastrocnemius	PROPN
bam-1791	181	25	(	(	PUNCT
bam-1791	181	26	gc	gc	PROPN
bam-1791	181	27	)	)	PUNCT
bam-1791	181	28	muscles	muscle	NOUN
bam-1791	181	29	of	of	ADP
bam-1791	181	30	mdx	mdx	NOUN
bam-1791	181	31	mice	mouse	NOUN
bam-1791	181	32	at	at	ADP
bam-1791	181	33	different	different	ADJ
bam-1791	181	34	ages	age	NOUN
bam-1791	181	35	.	.	PUNCT
bam-1791	182	1	we	we	PRON
bam-1791	182	2	found	find	VERB
bam-1791	182	3	slightly	slightly	ADV
bam-1791	182	4	higher	high	ADJ
bam-1791	182	5	levels	level	NOUN
bam-1791	182	6	of	of	ADP
bam-1791	182	7	pgc1α	pgc1α	PROPN
bam-1791	182	8	mrna	mrna	PROPN
bam-1791	182	9	in	in	ADP
bam-1791	182	10	mdx	mdx	NOUN
bam-1791	182	11	mice	mouse	NOUN
bam-1791	182	12	of	of	ADP
bam-1791	182	13	8	8	NUM
bam-1791	182	14	weeks	week	NOUN
bam-1791	182	15	of	of	ADP
bam-1791	182	16	age	age	NOUN
bam-1791	182	17	vs.	vs.	ADP
bam-1791	182	18	age	age	NOUN
bam-1791	182	19	-	-	PUNCT
bam-1791	182	20	matched	match	VERB
bam-1791	182	21	c57bl/10	c57bl/10	PROPN
bam-1791	182	22	(	(	PUNCT
bam-1791	182	23	wt	wt	NOUN
bam-1791	182	24	)	)	PUNCT
bam-1791	182	25	mice	mouse	NOUN
bam-1791	182	26	.	.	PUNCT
bam-1791	183	1	the	the	DET
bam-1791	183	2	increase	increase	NOUN
bam-1791	183	3	in	in	ADP
bam-1791	183	4	pgc1α	pgc1α	PROPN
bam-1791	183	5	became	become	VERB
bam-1791	183	6	highly	highly	ADV
bam-1791	183	7	significant	significant	ADJ
bam-1791	183	8	at	at	ADP
bam-1791	183	9	16	16	NUM
bam-1791	183	10	weeks	week	NOUN
bam-1791	183	11	of	of	ADP
bam-1791	183	12	age	age	NOUN
bam-1791	183	13	and	and	CCONJ
bam-1791	183	14	was	be	AUX
bam-1791	183	15	paralleled	parallel	VERB
bam-1791	183	16	by	by	ADP
bam-1791	183	17	an	an	DET
bam-1791	183	18	increased	increase	VERB
bam-1791	183	19	expression	expression	NOUN
bam-1791	183	20	of	of	ADP
bam-1791	183	21	sirt1	sirt1	PROPN
bam-1791	183	22	.	.	PUNCT
bam-1791	184	1	also	also	ADV
bam-1791	184	2	,	,	PUNCT
bam-1791	184	3	the	the	DET
bam-1791	184	4	expression	expression	NOUN
bam-1791	184	5	of	of	ADP
bam-1791	184	6	pparδ	pparδ	NOUN
bam-1791	184	7	,	,	PUNCT
bam-1791	184	8	a	a	DET
bam-1791	184	9	coregulator	coregulator	NOUN
bam-1791	184	10	of	of	ADP
bam-1791	184	11	the	the	DET
bam-1791	184	12	expression	expression	NOUN
bam-1791	184	13	of	of	ADP
bam-1791	184	14	β	β	NOUN
bam-1791	184	15	-	-	PUNCT
bam-1791	184	16	oxidation	oxidation	NOUN
bam-1791	184	17	enzymes	enzyme	NOUN
bam-1791	184	18	,	,	PUNCT
bam-1791	184	19	was	be	AUX
bam-1791	184	20	significantly	significantly	ADV
bam-1791	184	21	increased	increase	VERB
bam-1791	184	22	.	.	PUNCT
bam-1791	185	1	the	the	DET
bam-1791	185	2	impact	impact	NOUN
bam-1791	185	3	of	of	ADP
bam-1791	185	4	the	the	DET
bam-1791	185	5	above	above	ADJ
bam-1791	185	6	alterations	alteration	NOUN
bam-1791	185	7	on	on	ADP
bam-1791	185	8	metabolic	metabolic	NOUN
bam-1791	185	9	phenotype	phenotype	NOUN
bam-1791	185	10	has	have	AUX
bam-1791	185	11	been	be	AUX
bam-1791	185	12	evaluated	evaluate	VERB
bam-1791	185	13	on	on	ADP
bam-1791	185	14	genes	gene	NOUN
bam-1791	185	15	expression	expression	NOUN
bam-1791	185	16	of	of	ADP
bam-1791	185	17	myosin	myosin	PROPN
bam-1791	185	18	heavy	heavy	PROPN
bam-1791	185	19	chain	chain	NOUN
bam-1791	185	20	(	(	PUNCT
bam-1791	185	21	mhc	mhc	PROPN
bam-1791	185	22	)	)	PUNCT
bam-1791	185	23	isoforms	isoform	VERB
bam-1791	185	24	.	.	PUNCT
bam-1791	186	1	a	a	DET
bam-1791	186	2	significant	significant	ADJ
bam-1791	186	3	increase	increase	NOUN
bam-1791	186	4	of	of	ADP
bam-1791	186	5	slow	slow	ADJ
bam-1791	186	6	-	-	PUNCT
bam-1791	186	7	oxidative	oxidative	ADJ
bam-1791	186	8	type	type	NOUN
bam-1791	186	9	i	i	PROPN
bam-1791	186	10	mhc	mhc	PROPN
bam-1791	186	11	and	and	CCONJ
bam-1791	186	12	a	a	DET
bam-1791	186	13	decrease	decrease	NOUN
bam-1791	186	14	of	of	ADP
bam-1791	186	15	fast	fast	ADJ
bam-1791	186	16	-	-	PUNCT
bam-1791	186	17	glycolytic	glycolytic	ADJ
bam-1791	186	18	iib	iib	NOUN
bam-1791	186	19	mhc	mhc	PROPN
bam-1791	186	20	were	be	AUX
bam-1791	186	21	found	find	VERB
bam-1791	186	22	in	in	ADP
bam-1791	186	23	mdx	mdx	PROPN
bam-1791	186	24	gc	gc	PROPN
bam-1791	186	25	muscle	muscle	NOUN
bam-1791	186	26	vs.	vs.	ADP
bam-1791	186	27	wt	wt	NOUN
bam-1791	186	28	ones	one	NOUN
bam-1791	186	29	.	.	PUNCT
bam-1791	187	1	then	then	ADV
bam-1791	187	2	a	a	DET
bam-1791	187	3	modification	modification	NOUN
bam-1791	187	4	of	of	ADP
bam-1791	187	5	pgc1α	pgc1α	PROPN
bam-1791	187	6	pathway	pathway	NOUN
bam-1791	187	7	,	,	PUNCT
bam-1791	187	8	which	which	PRON
bam-1791	187	9	likely	likely	ADV
bam-1791	187	10	triggers	trigger	VERB
bam-1791	187	11	a	a	DET
bam-1791	187	12	protective	protective	ADJ
bam-1791	187	13	slow	slow	ADJ
bam-1791	187	14	-	-	PUNCT
bam-1791	187	15	oxidative	oxidative	ADJ
bam-1791	187	16	myofiber	myofiber	NOUN
bam-1791	187	17	program	program	NOUN
bam-1791	187	18	,	,	PUNCT
bam-1791	187	19	naturally	naturally	ADV
bam-1791	187	20	occurs	occur	VERB
bam-1791	187	21	in	in	ADP
bam-1791	187	22	the	the	DET
bam-1791	187	23	mdx	mdx	NOUN
bam-1791	187	24	mouse	mouse	NOUN
bam-1791	187	25	muscle	muscle	NOUN
bam-1791	187	26	and	and	CCONJ
bam-1791	187	27	may	may	AUX
bam-1791	187	28	modulate	modulate	VERB
bam-1791	187	29	the	the	DET
bam-1791	187	30	outcome	outcome	NOUN
bam-1791	187	31	of	of	ADP
bam-1791	187	32	physiological	physiological	ADJ
bam-1791	187	33	stimuli	stimulus	NOUN
bam-1791	187	34	and	and	CCONJ
bam-1791	187	35	of	of	ADP
bam-1791	187	36	pharmacological	pharmacological	ADJ
bam-1791	187	37	strategies	strategy	NOUN
bam-1791	187	38	.	.	PUNCT
bam-1791	188	1	upstream	upstream	ADJ
bam-1791	188	2	mechanisms	mechanism	NOUN
bam-1791	188	3	triggering	trigger	VERB
bam-1791	188	4	the	the	DET
bam-1791	188	5	above	above	ADJ
bam-1791	188	6	changes	change	NOUN
bam-1791	188	7	and	and	CCONJ
bam-1791	188	8	their	their	PRON
bam-1791	188	9	functional	functional	ADJ
bam-1791	188	10	outcome	outcome	NOUN
bam-1791	188	11	are	be	AUX
bam-1791	188	12	currently	currently	ADV
bam-1791	188	13	under	under	ADP
bam-1791	188	14	investigation	investigation	NOUN
bam-1791	188	15	(	(	PUNCT
bam-1791	188	16	supported	support	VERB
bam-1791	188	17	by	by	ADP
bam-1791	188	18	duchenne	duchenne	NOUN
bam-1791	188	19	parent	parent	NOUN
bam-1791	188	20	project	project	NOUN
bam-1791	188	21	nl	nl	PROPN
bam-1791	188	22	)	)	PUNCT
bam-1791	188	23	.	.	PUNCT
bam-1791	189	1	16	16	NUM
bam-1791	189	2	.	.	PUNCT
bam-1791	189	3	intraperitoneal	intraperitoneal	ADJ
bam-1791	189	4	transplantation	transplantation	NOUN
bam-1791	189	5	of	of	ADP
bam-1791	189	6	microencapsulated	microencapsulate	VERB
bam-1791	189	7	sertoli	sertoli	NOUN
bam-1791	189	8	cells	cell	NOUN
bam-1791	189	9	counteracts	counteract	VERB
bam-1791	189	10	muscle	muscle	NOUN
bam-1791	189	11	inflammation	inflammation	NOUN
bam-1791	189	12	and	and	CCONJ
bam-1791	189	13	rescues	rescue	NOUN
bam-1791	189	14	muscle	muscle	NOUN
bam-1791	189	15	performance	performance	NOUN
bam-1791	189	16	in	in	ADP
bam-1791	189	17	mdx	mdx	PROPN
bam-1791	189	18	mice	mice	PROPN
bam-1791	189	19	sara	sara	PROPN
bam-1791	189	20	chiappalupi1	chiappalupi1	PROPN
bam-1791	189	21	,	,	PUNCT
bam-1791	189	22	guglielmo	guglielmo	PROPN
bam-1791	189	23	sorci1	sorci1	PROPN
bam-1791	189	24	,	,	PUNCT
bam-1791	189	25	giovanni	giovanni	PROPN
bam-1791	189	26	luca1	luca1	PROPN
bam-1791	189	27	,	,	PUNCT
bam-1791	189	28	francesca	francesca	PROPN
bam-1791	189	29	fallarino1	fallarino1	PROPN
bam-1791	189	30	,	,	PUNCT
bam-1791	189	31	francesca	francesca	PROPN
bam-1791	189	32	mancuso1	mancuso1	PROPN
bam-1791	189	33	,	,	PUNCT
bam-1791	189	34	luca	luca	PROPN
bam-1791	189	35	madaro3	madaro3	PROPN
bam-1791	189	36	,	,	PUNCT
bam-1791	189	37	carmine	carmine	PROPN
bam-1791	189	38	nicoletti3	nicoletti3	PROPN
bam-1791	189	39	,	,	PUNCT
bam-1791	189	40	mario	mario	PROPN
bam-1791	189	41	calvitti1	calvitti1	PROPN
bam-1791	189	42	,	,	PUNCT
bam-1791	189	43	iva	iva	PROPN
bam-1791	189	44	arato1	arato1	PROPN
bam-1791	189	45	,	,	PUNCT
bam-1791	189	46	giulia	giulia	PROPN
bam-1791	189	47	falabella1	falabella1	PROPN
bam-1791	189	48	,	,	PUNCT
bam-1791	189	49	riccardo	riccardo	PROPN
bam-1791	189	50	calafiore2	calafiore2	PROPN
bam-1791	189	51	,	,	PUNCT
bam-1791	189	52	and	and	CCONJ
bam-1791	189	53	rosario	rosario	PROPN
bam-1791	189	54	donato1	donato1	PROPN
bam-1791	189	55	1	1	NUM
bam-1791	189	56	dept	dept	NOUN
bam-1791	189	57	experimental	experimental	ADJ
bam-1791	189	58	medicine	medicine	NOUN
bam-1791	189	59	&	&	CCONJ
bam-1791	189	60	biochemical	biochemical	ADJ
bam-1791	189	61	sciences	sciences	PROPN
bam-1791	189	62	,	,	PUNCT
bam-1791	189	63	university	university	NOUN
bam-1791	189	64	of	of	ADP
bam-1791	189	65	perugia	perugia	PROPN
bam-1791	189	66	,	,	PUNCT
bam-1791	189	67	perugia	perugia	PROPN
bam-1791	189	68	,	,	PUNCT
bam-1791	189	69	italy	italy	PROPN
bam-1791	189	70	;	;	PUNCT
bam-1791	189	71	2	2	NUM
bam-1791	189	72	dept	dept	NOUN
bam-1791	189	73	internal	internal	ADJ
bam-1791	189	74	medicine	medicine	NOUN
bam-1791	189	75	,	,	PUNCT
bam-1791	189	76	university	university	PROPN
bam-1791	189	77	of	of	ADP
bam-1791	189	78	perugia	perugia	PROPN
bam-1791	189	79	,	,	PUNCT
bam-1791	189	80	perugia	perugia	PROPN
bam-1791	189	81	,	,	PUNCT
bam-1791	189	82	italy	italy	PROPN
bam-1791	189	83	;	;	PUNCT
bam-1791	189	84	3	3	NUM
bam-1791	189	85	unit	unit	NOUN
bam-1791	189	86	of	of	ADP
bam-1791	189	87	histology	histology	NOUN
bam-1791	189	88	,	,	PUNCT
bam-1791	189	89	dahfmo	dahfmo	PROPN
bam-1791	189	90	,	,	PUNCT
bam-1791	189	91	la	la	PROPN
bam-1791	189	92	sapienza	sapienza	PROPN
bam-1791	189	93	university	university	PROPN
bam-1791	189	94	,	,	PUNCT
bam-1791	189	95	rome	rome	PROPN
bam-1791	189	96	duchenne	duchenne	PROPN
bam-1791	189	97	muscular	muscular	ADJ
bam-1791	189	98	dystrophy	dystrophy	NOUN
bam-1791	189	99	(	(	PUNCT
bam-1791	189	100	dmd	dmd	NOUN
bam-1791	189	101	)	)	PUNCT
bam-1791	189	102	,	,	PUNCT
bam-1791	189	103	a	a	DET
bam-1791	189	104	progressive	progressive	ADJ
bam-1791	189	105	muscle	muscle	NOUN
bam-1791	189	106	degenerative	degenerative	ADJ
bam-1791	189	107	disease	disease	NOUN
bam-1791	189	108	associated	associate	VERB
bam-1791	189	109	with	with	ADP
bam-1791	189	110	chronic	chronic	ADJ
bam-1791	189	111	inflammation	inflammation	NOUN
bam-1791	189	112	,	,	PUNCT
bam-1791	189	113	necrosis	necrosis	NOUN
bam-1791	189	114	and	and	CCONJ
bam-1791	189	115	fibrosis	fibrosis	NOUN
bam-1791	189	116	,	,	PUNCT
bam-1791	189	117	is	be	AUX
bam-1791	189	118	currently	currently	ADV
bam-1791	189	119	treated	treat	VERB
bam-1791	189	120	with	with	ADP
bam-1791	189	121	antiinflammatory	antiinflammatory	NOUN
bam-1791	189	122	steroids	steroid	NOUN
bam-1791	189	123	,	,	PUNCT
bam-1791	189	124	despite	despite	SCONJ
bam-1791	189	125	their	their	PRON
bam-1791	189	126	limited	limited	ADJ
bam-1791	189	127	efficacy	efficacy	NOUN
bam-1791	189	128	and	and	CCONJ
bam-1791	189	129	undesired	undesired	ADJ
bam-1791	189	130	side	side	NOUN
bam-1791	189	131	effects	effect	NOUN
bam-1791	189	132	.	.	PUNCT
bam-1791	190	1	testicular	testicular	ADJ
bam-1791	190	2	sertoli	sertoli	NOUN
bam-1791	190	3	cells	cell	NOUN
bam-1791	190	4	(	(	PUNCT
bam-1791	190	5	scs	scs	PROPN
bam-1791	190	6	)	)	PUNCT
bam-1791	190	7	have	have	AUX
bam-1791	190	8	been	be	AUX
bam-1791	190	9	successfully	successfully	ADV
bam-1791	190	10	implanted	implant	VERB
bam-1791	190	11	to	to	PART
bam-1791	190	12	treat	treat	VERB
bam-1791	190	13	many	many	ADJ
bam-1791	190	14	experimental	experimental	ADJ
bam-1791	190	15	diseases	disease	NOUN
bam-1791	190	16	due	due	ADP
bam-1791	190	17	to	to	ADP
bam-1791	190	18	their	their	PRON
bam-1791	190	19	ability	ability	NOUN
bam-1791	190	20	to	to	PART
bam-1791	190	21	secrete	secrete	VERB
bam-1791	190	22	trophic	trophic	ADJ
bam-1791	190	23	,	,	PUNCT
bam-1791	190	24	antiinflammatory	antiinflammatory	NOUN
bam-1791	190	25	and	and	CCONJ
bam-1791	190	26	immunomodulatory	immunomodulatory	ADJ
bam-1791	190	27	molecules	molecule	NOUN
bam-1791	190	28	[	[	X
bam-1791	190	29	1	1	NUM
bam-1791	190	30	]	]	PUNCT
bam-1791	190	31	.	.	PUNCT
bam-1791	191	1	we	we	PRON
bam-1791	191	2	transplanted	transplant	VERB
bam-1791	191	3	microencapsulated	microencapsulate	VERB
bam-1791	191	4	scs	scs	PROPN
bam-1791	191	5	,	,	PUNCT
bam-1791	191	6	within	within	ADP
bam-1791	191	7	highly	highly	ADV
bam-1791	191	8	biocompatible	biocompatible	ADJ
bam-1791	191	9	microcapsules	microcapsule	NOUN
bam-1791	191	10	[	[	X
bam-1791	191	11	2	2	NUM
bam-1791	191	12	]	]	PUNCT
bam-1791	191	13	into	into	ADP
bam-1791	191	14	the	the	DET
bam-1791	191	15	peritoneal	peritoneal	ADJ
bam-1791	191	16	cavity	cavity	NOUN
bam-1791	191	17	of	of	ADP
bam-1791	191	18	mdx	mdx	NOUN
bam-1791	191	19	mice	mouse	NOUN
bam-1791	191	20	,	,	PUNCT
bam-1791	191	21	an	an	DET
bam-1791	191	22	animal	animal	NOUN
bam-1791	191	23	model	model	NOUN
bam-1791	191	24	of	of	ADP
bam-1791	191	25	dmd	dmd	PROPN
bam-1791	191	26	.	.	PUNCT
bam-1791	191	27	skeletal	skeletal	ADJ
bam-1791	191	28	muscles	muscle	NOUN
bam-1791	191	29	from	from	ADP
bam-1791	191	30	sc	sc	NOUN
bam-1791	191	31	-	-	PUNCT
bam-1791	191	32	treated	treat	VERB
bam-1791	191	33	mdx	mdx	NOUN
bam-1791	191	34	mice	mouse	NOUN
bam-1791	191	35	,	,	PUNCT
bam-1791	191	36	compared	compare	VERB
bam-1791	191	37	with	with	ADP
bam-1791	191	38	muscles	muscle	NOUN
bam-1791	191	39	from	from	ADP
bam-1791	191	40	mocktreated	mocktreate	VERB
bam-1791	191	41	mice	mouse	NOUN
bam-1791	191	42	displayed	display	VERB
bam-1791	191	43	reduced	reduced	ADJ
bam-1791	191	44	necrosis	necrosis	NOUN
bam-1791	191	45	,	,	PUNCT
bam-1791	191	46	improved	improve	VERB
bam-1791	191	47	regeneration	regeneration	NOUN
bam-1791	191	48	and	and	CCONJ
bam-1791	191	49	depletion	depletion	NOUN
bam-1791	191	50	of	of	ADP
bam-1791	191	51	infiltrated	infiltrate	VERB
bam-1791	191	52	inflammatory	inflammatory	ADJ
bam-1791	191	53	cells	cell	NOUN
bam-1791	191	54	,	,	PUNCT
bam-1791	191	55	with	with	ADP
bam-1791	191	56	a	a	DET
bam-1791	191	57	significant	significant	ADJ
bam-1791	191	58	reduction	reduction	NOUN
bam-1791	191	59	of	of	ADP
bam-1791	191	60	the	the	DET
bam-1791	191	61	number	number	NOUN
bam-1791	191	62	of	of	ADP
bam-1791	191	63	macrophages	macrophage	NOUN
bam-1791	191	64	already	already	ADV
bam-1791	191	65	one	one	NUM
bam-1791	191	66	week	week	NOUN
bam-1791	191	67	after	after	ADP
bam-1791	191	68	transplantation	transplantation	NOUN
bam-1791	191	69	.	.	PUNCT
bam-1791	192	1	serum	serum	VERB
bam-1791	192	2	ifn	ifn	PROPN
bam-1791	192	3	-	-	PUNCT
bam-1791	192	4	gamma	gamma	NOUN
bam-1791	192	5	,	,	PUNCT
bam-1791	192	6	a	a	DET
bam-1791	192	7	strong	strong	ADJ
bam-1791	192	8	inducer	inducer	NOUN
bam-1791	192	9	of	of	ADP
bam-1791	192	10	pro	pro	ADJ
bam-1791	192	11	-	-	ADJ
bam-1791	192	12	inflammatory	inflammatory	ADJ
bam-1791	192	13	macrophages	macrophage	NOUN
bam-1791	192	14	elevated	elevate	VERB
bam-1791	192	15	in	in	ADP
bam-1791	192	16	mdx	mdx	NOUN
bam-1791	192	17	mice	mouse	NOUN
bam-1791	192	18	was	be	AUX
bam-1791	192	19	significantly	significantly	ADV
bam-1791	192	20	reduced	reduce	VERB
bam-1791	192	21	in	in	ADP
bam-1791	192	22	sc	sc	PROPN
bam-1791	192	23	-	-	PUNCT
bam-1791	192	24	treated	treat	VERB
bam-1791	192	25	mice	mouse	NOUN
bam-1791	192	26	.	.	PUNCT
bam-1791	193	1	three	three	NUM
bam-1791	193	2	weeks	week	NOUN
bam-1791	193	3	after	after	SCONJ
bam-1791	193	4	transplantation	transplantation	NOUN
bam-1791	193	5	sc	sc	PROPN
bam-1791	193	6	-	-	PUNCT
bam-1791	193	7	treated	treat	VERB
bam-1791	193	8	,	,	PUNCT
bam-1791	193	9	but	but	CCONJ
bam-1791	193	10	not	not	PART
bam-1791	193	11	mock	mock	ADV
bam-1791	193	12	-	-	PUNCT
bam-1791	193	13	treated	treat	VERB
bam-1791	193	14	mdx	mdx	NOUN
bam-1791	193	15	mice	mouse	NOUN
bam-1791	193	16	showed	show	VERB
bam-1791	193	17	recovery	recovery	NOUN
bam-1791	193	18	of	of	ADP
bam-1791	193	19	muscle	muscle	NOUN
bam-1791	193	20	performance	performance	NOUN
bam-1791	193	21	in	in	ADP
bam-1791	193	22	treadmill	treadmill	ADJ
bam-1791	193	23	running	running	NOUN
bam-1791	193	24	tests	test	NOUN
bam-1791	193	25	,	,	PUNCT
bam-1791	193	26	and	and	CCONJ
bam-1791	193	27	a	a	DET
bam-1791	193	28	comparable	comparable	ADJ
bam-1791	193	29	resistance	resistance	NOUN
bam-1791	193	30	to	to	ADP
bam-1791	193	31	exercise	exercise	NOUN
bam-1791	193	32	-	-	PUNCT
bam-1791	193	33	induced	induce	VERB
bam-1791	193	34	muscle	muscle	NOUN
bam-1791	193	35	damage	damage	NOUN
bam-1791	193	36	to	to	ADP
bam-1791	193	37	that	that	PRON
bam-1791	193	38	of	of	ADP
bam-1791	193	39	untreated	untreated	ADJ
bam-1791	193	40	wildtype	wildtype	NOUN
bam-1791	193	41	mice	mouse	NOUN
bam-1791	193	42	.	.	PUNCT
bam-1791	194	1	unexpectedly	unexpectedly	ADV
bam-1791	194	2	,	,	PUNCT
bam-1791	194	3	muscles	muscle	NOUN
bam-1791	194	4	from	from	ADP
bam-1791	194	5	sc	sc	PROPN
bam-1791	194	6	-	-	PUNCT
bam-1791	194	7	treated	treat	VERB
bam-1791	194	8	mdx	mdx	NOUN
bam-1791	194	9	mice	mouse	NOUN
bam-1791	194	10	showed	show	VERB
bam-1791	194	11	an	an	DET
bam-1791	194	12	increased	increase	VERB
bam-1791	194	13	expression	expression	NOUN
bam-1791	194	14	of	of	ADP
bam-1791	194	15	the	the	DET
bam-1791	194	16	dystrophin	dystrophin	NOUN
bam-1791	194	17	-	-	PUNCT
bam-1791	194	18	related	relate	VERB
bam-1791	194	19	gene	gene	NOUN
bam-1791	194	20	,	,	PUNCT
bam-1791	194	21	utrophin	utrophin	PROPN
bam-1791	194	22	(	(	PUNCT
bam-1791	194	23	utrn	utrn	NOUN
bam-1791	194	24	)	)	PUNCT
bam-1791	194	25	which	which	PRON
bam-1791	194	26	might	might	AUX
bam-1791	194	27	contribute	contribute	VERB
bam-1791	194	28	to	to	ADP
bam-1791	194	29	the	the	DET
bam-1791	194	30	recovery	recovery	NOUN
bam-1791	194	31	of	of	ADP
bam-1791	194	32	muscle	muscle	NOUN
bam-1791	194	33	homeostasis	homeostasis	NOUN
bam-1791	194	34	.	.	PUNCT
bam-1791	195	1	similarly	similarly	ADV
bam-1791	195	2	to	to	ADP
bam-1791	195	3	mdx	mdx	NOUN
bam-1791	195	4	mice	mouse	NOUN
bam-1791	195	5	,	,	PUNCT
bam-1791	195	6	transplantation	transplantation	NOUN
bam-1791	195	7	of	of	ADP
bam-1791	195	8	scs	scs	PROPN
bam-1791	195	9	in	in	ADP
bam-1791	195	10	an	an	DET
bam-1791	195	11	experimental	experimental	ADJ
bam-1791	195	12	model	model	NOUN
bam-1791	195	13	of	of	ADP
bam-1791	195	14	autoimmune	autoimmune	PROPN
bam-1791	195	15	myositis	myositis	PROPN
bam-1791	195	16	resulted	result	VERB
bam-1791	195	17	in	in	ADP
bam-1791	195	18	the	the	DET
bam-1791	195	19	recovery	recovery	NOUN
bam-1791	195	20	of	of	ADP
bam-1791	195	21	limb	limb	NOUN
bam-1791	195	22	muscle	muscle	NOUN
bam-1791	195	23	mass	mass	PROPN
bam-1791	195	24	ix	ix	PROPN
bam-1791	195	25	iim	iim	PROPN
bam-1791	195	26	meeting	meeting	NOUN
bam-1791	195	27	,	,	PUNCT
bam-1791	195	28	acaya	acaya	NOUN
bam-1791	195	29	(	(	PUNCT
bam-1791	195	30	lecce	lecce	PROPN
bam-1791	195	31	)	)	PUNCT
bam-1791	195	32	,	,	PUNCT
bam-1791	195	33	october	october	PROPN
bam-1791	195	34	12	12	NUM
bam-1791	195	35	-	-	SYM
bam-1791	195	36	14	14	NUM
bam-1791	195	37	,	,	PUNCT
bam-1791	195	38	2012	2012	NUM
bam-1791	195	39	european	european	PROPN
bam-1791	195	40	journal	journal	PROPN
bam-1791	195	41	translational	translational	ADJ
bam-1791	195	42	myology	myology	NOUN
bam-1791	195	43	basic	basic	ADJ
bam-1791	195	44	applied	apply	VERB
bam-1791	195	45	myology	myology	NOUN
bam-1791	195	46	2012	2012	NUM
bam-1791	195	47	;	;	PUNCT
bam-1791	195	48	22(1&2	22(1&2	NUM
bam-1791	195	49	):	):	PUNCT
bam-1791	195	50	xxx	xxx	NOUN
bam-1791	195	51	-	-	PUNCT
bam-1791	195	52	xxx	xxx	NOUN
bam-1791	195	53	27	27	NUM
bam-1791	195	54	and	and	CCONJ
bam-1791	195	55	dramatic	dramatic	ADJ
bam-1791	195	56	reduction	reduction	NOUN
bam-1791	195	57	of	of	ADP
bam-1791	195	58	necrosis	necrosis	NOUN
bam-1791	195	59	in	in	ADP
bam-1791	195	60	diaphragm	diaphragm	PROPN
bam-1791	195	61	.	.	PUNCT
bam-1791	196	1	our	our	PRON
bam-1791	196	2	results	result	NOUN
bam-1791	196	3	suggest	suggest	VERB
bam-1791	196	4	that	that	SCONJ
bam-1791	196	5	i.p	i.p	PROPN
bam-1791	196	6	.	.	PROPN
bam-1791	196	7	transplantation	transplantation	NOUN
bam-1791	196	8	of	of	ADP
bam-1791	196	9	microencapsulated	microencapsulate	VERB
bam-1791	196	10	scs	scs	PROPN
bam-1791	196	11	might	might	AUX
bam-1791	196	12	represent	represent	VERB
bam-1791	196	13	a	a	DET
bam-1791	196	14	powerful	powerful	ADJ
bam-1791	196	15	means	mean	NOUN
bam-1791	196	16	to	to	PART
bam-1791	196	17	reduce	reduce	VERB
bam-1791	196	18	muscle	muscle	NOUN
bam-1791	196	19	inflammation	inflammation	NOUN
bam-1791	196	20	and	and	CCONJ
bam-1791	196	21	create	create	VERB
bam-1791	196	22	a	a	DET
bam-1791	196	23	more	more	ADV
bam-1791	196	24	suitable	suitable	ADJ
bam-1791	196	25	microenvironment	microenvironment	NOUN
bam-1791	196	26	for	for	ADP
bam-1791	196	27	muscle	muscle	NOUN
bam-1791	196	28	regeneration	regeneration	NOUN
bam-1791	196	29	and	and	CCONJ
bam-1791	196	30	the	the	DET
bam-1791	196	31	recovery	recovery	NOUN
bam-1791	196	32	of	of	ADP
bam-1791	196	33	muscle	muscle	NOUN
bam-1791	196	34	performance	performance	NOUN
bam-1791	196	35	in	in	ADP
bam-1791	196	36	animals	animal	NOUN
bam-1791	196	37	and	and	CCONJ
bam-1791	196	38	,	,	PUNCT
bam-1791	196	39	possibly	possibly	ADV
bam-1791	196	40	patients	patient	NOUN
bam-1791	196	41	affected	affect	VERB
bam-1791	196	42	from	from	ADP
bam-1791	196	43	dmd	dmd	NOUN
bam-1791	196	44	or	or	CCONJ
bam-1791	196	45	inflammatory	inflammatory	ADJ
bam-1791	196	46	myopathies	myopathy	NOUN
bam-1791	196	47	.	.	PUNCT
bam-1791	197	1	[	[	X
bam-1791	197	2	1	1	X
bam-1791	197	3	]	]	X
bam-1791	197	4	mital	mital	NOUN
bam-1791	197	5	et	et	PROPN
bam-1791	197	6	al	al	PROPN
bam-1791	197	7	.	.	PUNCT
bam-1791	197	8	reproduction	reproduction	NOUN
bam-1791	197	9	139(2010):495	139(2010):495	NUM
bam-1791	197	10	-	-	SYM
bam-1791	197	11	504	504	NUM
bam-1791	197	12	;	;	PUNCT
bam-1791	197	13	[	[	X
bam-1791	197	14	2	2	X
bam-1791	197	15	]	]	X
bam-1791	197	16	luca	luca	PROPN
bam-1791	197	17	et	et	PROPN
bam-1791	197	18	al	al	PROPN
bam-1791	197	19	.	.	PROPN
bam-1791	197	20	tissue	tissue	NOUN
bam-1791	197	21	eng	eng	PROPN
bam-1791	197	22	13(2007):641	13(2007):641	NUM
bam-1791	197	23	-	-	SYM
bam-1791	197	24	8	8	NUM
bam-1791	197	25	.	.	PUNCT
bam-1791	197	26	17	17	NUM
bam-1791	197	27	.	.	PUNCT
bam-1791	198	1	obscurin	obscurin	PROPN
bam-1791	198	2	is	be	AUX
bam-1791	198	3	required	require	VERB
bam-1791	198	4	for	for	ADP
bam-1791	198	5	ankyrinb	ankyrinb	ADJ
bam-1791	198	6	-	-	PUNCT
bam-1791	198	7	dependent	dependent	ADJ
bam-1791	198	8	localization	localization	NOUN
bam-1791	198	9	of	of	ADP
bam-1791	198	10	dystrophin	dystrophin	ADJ
bam-1791	198	11	and	and	CCONJ
bam-1791	198	12	sarcolemmal	sarcolemmal	ADJ
bam-1791	198	13	integrity	integrity	NOUN
bam-1791	198	14	in	in	ADP
bam-1791	198	15	skeletal	skeletal	ADJ
bam-1791	198	16	muscle	muscle	NOUN
bam-1791	198	17	fibers	fiber	NOUN
bam-1791	198	18	1davide	1davide	NUM
bam-1791	198	19	randazzo	randazzo	VERB
bam-1791	198	20	,	,	PUNCT
bam-1791	198	21	1emiliana	1emiliana	PROPN
bam-1791	198	22	giacomello	giacomello	NOUN
bam-1791	198	23	,	,	PUNCT
bam-1791	198	24	1stefania	1stefania	NUM
bam-1791	198	25	lorenzini	lorenzini	NOUN
bam-1791	198	26	,	,	PUNCT
bam-1791	198	27	2	2	NUM
bam-1791	198	28	carlo	carlo	NOUN
bam-1791	198	29	reggiani	reggiani	NOUN
bam-1791	198	30	,	,	PUNCT
bam-1791	198	31	3stephan	3stephan	NUM
bam-1791	198	32	lange	lange	NOUN
bam-1791	198	33	,	,	PUNCT
bam-1791	198	34	3angela	3angela	PROPN
bam-1791	198	35	k.	k.	PROPN
bam-1791	198	36	peter	peter	PROPN
bam-1791	198	37	,	,	PUNCT
bam-1791	198	38	3ju	3ju	ADJ
bam-1791	198	39	chen	chen	PROPN
bam-1791	198	40	and	and	CCONJ
bam-1791	198	41	1vincenzo	1vincenzo	NUM
bam-1791	198	42	sorrentino	sorrentino	PROPN
bam-1791	198	43	1molecular	1molecular	NUM
bam-1791	198	44	medicine	medicine	NOUN
bam-1791	198	45	section	section	NOUN
bam-1791	198	46	,	,	PUNCT
bam-1791	198	47	department	department	NOUN
bam-1791	198	48	of	of	ADP
bam-1791	198	49	molecular	molecular	ADJ
bam-1791	198	50	and	and	CCONJ
bam-1791	198	51	developmental	developmental	ADJ
bam-1791	198	52	medicine	medicine	NOUN
bam-1791	198	53	,	,	PUNCT
bam-1791	198	54	university	university	PROPN
bam-1791	198	55	of	of	ADP
bam-1791	198	56	siena	siena	PROPN
bam-1791	198	57	,	,	PUNCT
bam-1791	198	58	via	via	ADP
bam-1791	198	59	a	a	DET
bam-1791	198	60	moro	moro	PROPN
bam-1791	198	61	2	2	NUM
bam-1791	198	62	,	,	PUNCT
bam-1791	198	63	53100	53100	NUM
bam-1791	198	64	siena	siena	PROPN
bam-1791	198	65	,	,	PUNCT
bam-1791	198	66	italy	italy	PROPN
bam-1791	198	67	,	,	PUNCT
bam-1791	198	68	2department	2department	NUM
bam-1791	198	69	of	of	ADP
bam-1791	198	70	biomedical	biomedical	ADJ
bam-1791	198	71	sciences	science	NOUN
bam-1791	198	72	,	,	PUNCT
bam-1791	198	73	university	university	PROPN
bam-1791	198	74	of	of	ADP
bam-1791	198	75	padua	padua	PROPN
bam-1791	198	76	,	,	PUNCT
bam-1791	198	77	italy	italy	PROPN
bam-1791	198	78	,	,	PUNCT
bam-1791	198	79	3university	3university	PROPN
bam-1791	198	80	of	of	ADP
bam-1791	198	81	california	california	PROPN
bam-1791	198	82	san	san	PROPN
bam-1791	198	83	diego	diego	PROPN
bam-1791	198	84	,	,	PUNCT
bam-1791	198	85	school	school	NOUN
bam-1791	198	86	of	of	ADP
bam-1791	198	87	medicine	medicine	NOUN
bam-1791	198	88	,	,	PUNCT
bam-1791	198	89	9500	9500	NUM
bam-1791	198	90	gilman	gilman	PROPN
bam-1791	198	91	drive	drive	NOUN
bam-1791	198	92	,	,	PUNCT
bam-1791	198	93	ca-92093	ca-92093	PROPN
bam-1791	198	94	la	la	PROPN
bam-1791	198	95	jolla	jolla	PROPN
bam-1791	198	96	,	,	PUNCT
bam-1791	198	97	usa	usa	PROPN
bam-1791	198	98	obscurin	obscurin	PROPN
bam-1791	198	99	is	be	AUX
bam-1791	198	100	a	a	DET
bam-1791	198	101	large	large	ADJ
bam-1791	198	102	myofibrillar	myofibrillar	ADJ
bam-1791	198	103	protein	protein	NOUN
bam-1791	198	104	that	that	PRON
bam-1791	198	105	contains	contain	VERB
bam-1791	198	106	several	several	ADJ
bam-1791	198	107	interacting	interact	VERB
bam-1791	198	108	modules	module	NOUN
bam-1791	198	109	,	,	PUNCT
bam-1791	198	110	one	one	NUM
bam-1791	198	111	of	of	ADP
bam-1791	198	112	which	which	PRON
bam-1791	198	113	mediates	mediate	NOUN
bam-1791	198	114	binding	bind	VERB
bam-1791	198	115	to	to	ADP
bam-1791	198	116	muscle	muscle	NOUN
bam-1791	198	117	-	-	PUNCT
bam-1791	198	118	specific	specific	ADJ
bam-1791	198	119	ankyrins	ankyrin	NOUN
bam-1791	198	120	.	.	PUNCT
bam-1791	199	1	interaction	interaction	NOUN
bam-1791	199	2	between	between	ADP
bam-1791	199	3	obscurin	obscurin	NOUN
bam-1791	199	4	and	and	CCONJ
bam-1791	199	5	the	the	DET
bam-1791	199	6	muscle	muscle	NOUN
bam-1791	199	7	-	-	PUNCT
bam-1791	199	8	specific	specific	ADJ
bam-1791	199	9	ankyrin	ankyrin	NOUN
bam-1791	199	10	sank1.5	sank1.5	PUNCT
bam-1791	199	11	has	have	AUX
bam-1791	199	12	been	be	AUX
bam-1791	199	13	found	find	VERB
bam-1791	199	14	to	to	PART
bam-1791	199	15	regulate	regulate	VERB
bam-1791	199	16	the	the	DET
bam-1791	199	17	organization	organization	NOUN
bam-1791	199	18	of	of	ADP
bam-1791	199	19	the	the	DET
bam-1791	199	20	sarcoplasmic	sarcoplasmic	NOUN
bam-1791	199	21	reticulum	reticulum	NOUN
bam-1791	199	22	in	in	ADP
bam-1791	199	23	striated	striated	ADJ
bam-1791	199	24	muscles	muscle	NOUN
bam-1791	199	25	.	.	PUNCT
bam-1791	200	1	additional	additional	ADJ
bam-1791	200	2	muscle	muscle	NOUN
bam-1791	200	3	-	-	PUNCT
bam-1791	200	4	specific	specific	ADJ
bam-1791	200	5	ankyrin	ankyrin	ADJ
bam-1791	200	6	isoforms	isoform	NOUN
bam-1791	200	7	,	,	PUNCT
bam-1791	200	8	namely	namely	ADV
bam-1791	200	9	ankb	ankb	NOUN
bam-1791	200	10	and	and	CCONJ
bam-1791	200	11	ankg	ankg	NOUN
bam-1791	200	12	,	,	PUNCT
bam-1791	200	13	localized	localize	VERB
bam-1791	200	14	at	at	ADP
bam-1791	200	15	the	the	DET
bam-1791	200	16	sub	sub	ADJ
bam-1791	200	17	-	-	ADJ
bam-1791	200	18	sarcolemma	sarcolemma	ADJ
bam-1791	200	19	level	level	NOUN
bam-1791	200	20	have	have	AUX
bam-1791	200	21	been	be	AUX
bam-1791	200	22	shown	show	VERB
bam-1791	200	23	to	to	PART
bam-1791	200	24	contribute	contribute	VERB
bam-1791	200	25	to	to	ADP
bam-1791	200	26	the	the	DET
bam-1791	200	27	organization	organization	NOUN
bam-1791	200	28	of	of	ADP
bam-1791	200	29	dystrophin	dystrophin	NOUN
bam-1791	200	30	and	and	CCONJ
bam-1791	200	31	β	β	NOUN
bam-1791	200	32	-	-	NOUN
bam-1791	200	33	dystroglycan	dystroglycan	NOUN
bam-1791	200	34	at	at	ADP
bam-1791	200	35	costameres	costamere	NOUN
bam-1791	200	36	.	.	PUNCT
bam-1791	201	1	accordingly	accordingly	ADV
bam-1791	201	2	,	,	PUNCT
bam-1791	201	3	we	we	PRON
bam-1791	201	4	investigated	investigate	VERB
bam-1791	201	5	whether	whether	SCONJ
bam-1791	201	6	obscurin	obscurin	NOUN
bam-1791	201	7	might	might	AUX
bam-1791	201	8	be	be	AUX
bam-1791	201	9	involved	involve	VERB
bam-1791	201	10	in	in	ADP
bam-1791	201	11	the	the	DET
bam-1791	201	12	sub	sub	ADJ
bam-1791	201	13	-	-	ADJ
bam-1791	201	14	sarcolemma	sarcolemma	ADJ
bam-1791	201	15	localization	localization	NOUN
bam-1791	201	16	of	of	ADP
bam-1791	201	17	ankb	ankb	NOUN
bam-1791	201	18	and	and	CCONJ
bam-1791	201	19	ankg	ankg	NOUN
bam-1791	201	20	,	,	PUNCT
bam-1791	201	21	and	and	CCONJ
bam-1791	201	22	eventually	eventually	ADV
bam-1791	201	23	in	in	ADP
bam-1791	201	24	the	the	DET
bam-1791	201	25	assembly	assembly	NOUN
bam-1791	201	26	of	of	ADP
bam-1791	201	27	dystrophin	dystrophin	NOUN
bam-1791	201	28	and	and	CCONJ
bam-1791	201	29	βdystroglycan	βdystroglycan	NOUN
bam-1791	201	30	at	at	ADP
bam-1791	201	31	costameres	costamere	NOUN
bam-1791	201	32	in	in	ADP
bam-1791	201	33	skeletal	skeletal	ADJ
bam-1791	201	34	muscle	muscle	NOUN
bam-1791	201	35	fibers	fiber	NOUN
bam-1791	201	36	.	.	PUNCT
bam-1791	202	1	we	we	PRON
bam-1791	202	2	found	find	VERB
bam-1791	202	3	that	that	SCONJ
bam-1791	202	4	in	in	ADP
bam-1791	202	5	mice	mouse	NOUN
bam-1791	202	6	deficient	deficient	ADJ
bam-1791	202	7	for	for	ADP
bam-1791	202	8	obscurin	obscurin	NOUN
bam-1791	202	9	,	,	PUNCT
bam-1791	202	10	ankb	ankb	NOUN
bam-1791	202	11	was	be	AUX
bam-1791	202	12	displaced	displace	VERB
bam-1791	202	13	from	from	ADP
bam-1791	202	14	its	its	PRON
bam-1791	202	15	localization	localization	NOUN
bam-1791	202	16	at	at	ADP
bam-1791	202	17	the	the	DET
bam-1791	202	18	m	m	NOUN
bam-1791	202	19	-	-	NOUN
bam-1791	202	20	band	band	NOUN
bam-1791	202	21	,	,	PUNCT
bam-1791	202	22	while	while	SCONJ
bam-1791	202	23	localization	localization	NOUN
bam-1791	202	24	of	of	ADP
bam-1791	202	25	ankg	ankg	PRON
bam-1791	202	26	at	at	ADP
bam-1791	202	27	z	z	NOUN
bam-1791	202	28	-	-	PUNCT
bam-1791	202	29	disk	disk	NOUN
bam-1791	202	30	was	be	AUX
bam-1791	202	31	not	not	PART
bam-1791	202	32	affected	affect	VERB
bam-1791	202	33	.	.	PUNCT
bam-1791	203	1	in	in	ADP
bam-1791	203	2	obscurin	obscurin	PROPN
bam-1791	203	3	ko	ko	PROPN
bam-1791	203	4	mice	mouse	NOUN
bam-1791	203	5	,	,	PUNCT
bam-1791	203	6	localization	localization	NOUN
bam-1791	203	7	at	at	ADP
bam-1791	203	8	costameres	costamere	NOUN
bam-1791	203	9	of	of	ADP
bam-1791	203	10	dystrophin	dystrophin	NOUN
bam-1791	203	11	,	,	PUNCT
bam-1791	203	12	but	but	CCONJ
bam-1791	203	13	not	not	PART
bam-1791	203	14	of	of	ADP
bam-1791	203	15	β	β	NOUN
bam-1791	203	16	-	-	NOUN
bam-1791	203	17	dystroglycan	dystroglycan	NOUN
bam-1791	203	18	,	,	PUNCT
bam-1791	203	19	was	be	AUX
bam-1791	203	20	altered	alter	VERB
bam-1791	203	21	and	and	CCONJ
bam-1791	203	22	the	the	DET
bam-1791	203	23	sub	sub	ADJ
bam-1791	203	24	-	-	ADJ
bam-1791	203	25	sarcolemma	sarcolemma	ADJ
bam-1791	203	26	microtubule	microtubule	NOUN
bam-1791	203	27	cytoskeleton	cytoskeleton	PROPN
bam-1791	203	28	was	be	AUX
bam-1791	203	29	disrupted	disrupt	VERB
bam-1791	203	30	.	.	PUNCT
bam-1791	204	1	in	in	ADP
bam-1791	204	2	addition	addition	NOUN
bam-1791	204	3	,	,	PUNCT
bam-1791	204	4	these	these	DET
bam-1791	204	5	mutant	mutant	ADJ
bam-1791	204	6	mice	mouse	NOUN
bam-1791	204	7	displayed	display	VERB
bam-1791	204	8	marked	mark	VERB
bam-1791	204	9	sarcolemmal	sarcolemmal	ADJ
bam-1791	204	10	fragility	fragility	NOUN
bam-1791	204	11	and	and	CCONJ
bam-1791	204	12	reduced	reduce	VERB
bam-1791	204	13	muscle	muscle	NOUN
bam-1791	204	14	strength	strength	NOUN
bam-1791	204	15	.	.	PUNCT
bam-1791	205	1	altogether	altogether	ADV
bam-1791	205	2	,	,	PUNCT
bam-1791	205	3	these	these	DET
bam-1791	205	4	results	result	NOUN
bam-1791	205	5	support	support	VERB
bam-1791	205	6	a	a	DET
bam-1791	205	7	model	model	NOUN
bam-1791	205	8	where	where	SCONJ
bam-1791	205	9	obscurin	obscurin	NOUN
bam-1791	205	10	,	,	PUNCT
bam-1791	205	11	by	by	ADP
bam-1791	205	12	targeting	target	VERB
bam-1791	205	13	ankb	ankb	NOUN
bam-1791	205	14	at	at	ADP
bam-1791	205	15	the	the	DET
bam-1791	205	16	m	m	NOUN
bam-1791	205	17	-	-	NOUN
bam-1791	205	18	band	band	NOUN
bam-1791	205	19	,	,	PUNCT
bam-1791	205	20	contributes	contribute	VERB
bam-1791	205	21	to	to	ADP
bam-1791	205	22	the	the	DET
bam-1791	205	23	organization	organization	NOUN
bam-1791	205	24	of	of	ADP
bam-1791	205	25	sub	sub	ADJ
bam-1791	205	26	-	-	ADJ
bam-1791	205	27	sarcolemma	sarcolemma	ADJ
bam-1791	205	28	microtubules	microtubule	NOUN
bam-1791	205	29	,	,	PUNCT
bam-1791	205	30	localization	localization	NOUN
bam-1791	205	31	of	of	ADP
bam-1791	205	32	dystrophin	dystrophin	NOUN
bam-1791	205	33	at	at	ADP
bam-1791	205	34	costameres	costamere	NOUN
bam-1791	205	35	and	and	CCONJ
bam-1791	205	36	to	to	ADP
bam-1791	205	37	maintenance	maintenance	NOUN
bam-1791	205	38	of	of	ADP
bam-1791	205	39	sarcolemmal	sarcolemmal	ADJ
bam-1791	205	40	integrity	integrity	NOUN
bam-1791	205	41	.	.	PUNCT
bam-1791	206	1	these	these	DET
bam-1791	206	2	results	result	NOUN
bam-1791	206	3	add	add	VERB
bam-1791	206	4	a	a	DET
bam-1791	206	5	new	new	ADJ
bam-1791	206	6	twist	twist	NOUN
bam-1791	206	7	to	to	PART
bam-1791	206	8	obscurin	obscurin	ADJ
bam-1791	206	9	function	function	NOUN
bam-1791	206	10	due	due	ADP
bam-1791	206	11	to	to	ADP
bam-1791	206	12	interaction	interaction	NOUN
bam-1791	206	13	with	with	ADP
bam-1791	206	14	proteins	protein	NOUN
bam-1791	206	15	of	of	ADP
bam-1791	206	16	the	the	DET
bam-1791	206	17	extrasarcomeric	extrasarcomeric	ADJ
bam-1791	206	18	cytoskeleton	cytoskeleton	PROPN
bam-1791	206	19	.	.	PUNCT
bam-1791	207	1	accordingly	accordingly	ADV
bam-1791	207	2	,	,	PUNCT
bam-1791	207	3	obscurin	obscurin	PROPN
bam-1791	207	4	appears	appear	VERB
bam-1791	207	5	to	to	PART
bam-1791	207	6	represent	represent	VERB
bam-1791	207	7	a	a	DET
bam-1791	207	8	multifunctional	multifunctional	ADJ
bam-1791	207	9	anchoring	anchoring	NOUN
bam-1791	207	10	protein	protein	NOUN
bam-1791	207	11	that	that	PRON
bam-1791	207	12	on	on	ADP
bam-1791	207	13	one	one	NUM
bam-1791	207	14	hand	hand	NOUN
bam-1791	207	15	establishes	establish	VERB
bam-1791	207	16	interactions	interaction	NOUN
bam-1791	207	17	with	with	ADP
bam-1791	207	18	sarcomeric	sarcomeric	ADJ
bam-1791	207	19	proteins	protein	NOUN
bam-1791	207	20	and	and	CCONJ
bam-1791	207	21	on	on	ADP
bam-1791	207	22	the	the	DET
bam-1791	207	23	other	other	ADJ
bam-1791	207	24	hand	hand	NOUN
bam-1791	207	25	enables	enable	VERB
bam-1791	207	26	complex	complex	ADJ
bam-1791	207	27	formation	formation	NOUN
bam-1791	207	28	with	with	ADP
bam-1791	207	29	extrasarcomeric	extrasarcomeric	ADJ
bam-1791	207	30	proteins	protein	NOUN
bam-1791	207	31	,	,	PUNCT
bam-1791	207	32	like	like	ADP
bam-1791	207	33	the	the	DET
bam-1791	207	34	muscle	muscle	NOUN
bam-1791	207	35	-	-	PUNCT
bam-1791	207	36	specific	specific	ADJ
bam-1791	207	37	ankyrin	ankyrin	ADJ
bam-1791	207	38	isoforms	isoform	NOUN
bam-1791	207	39	,	,	PUNCT
bam-1791	207	40	that	that	PRON
bam-1791	207	41	help	help	VERB
bam-1791	207	42	to	to	PART
bam-1791	207	43	connect	connect	VERB
bam-1791	207	44	the	the	DET
bam-1791	207	45	sarcomeres	sarcomere	NOUN
bam-1791	207	46	with	with	ADP
bam-1791	207	47	the	the	DET
bam-1791	207	48	sr	sr	PROPN
bam-1791	207	49	and	and	CCONJ
bam-1791	207	50	with	with	ADP
bam-1791	207	51	the	the	DET
bam-1791	207	52	sub	sub	ADJ
bam-1791	207	53	-	-	ADJ
bam-1791	207	54	sarcolemmal	sarcolemmal	ADJ
bam-1791	207	55	cytoskeleton	cytoskeleton	NOUN
bam-1791	207	56	.	.	PUNCT
bam-1791	208	1	18	18	NUM
bam-1791	208	2	.	.	PUNCT
bam-1791	208	3	characterization	characterization	NOUN
bam-1791	208	4	of	of	ADP
bam-1791	208	5	the	the	DET
bam-1791	208	6	pkcθ	pkcθ	ADJ
bam-1791	208	7	dependent	dependent	ADJ
bam-1791	208	8	immune	immune	ADJ
bam-1791	208	9	response	response	NOUN
bam-1791	208	10	in	in	ADP
bam-1791	208	11	muscular	muscular	ADJ
bam-1791	208	12	dystrophy	dystrophy	NOUN
bam-1791	208	13	annunziata	annunziata	ADJ
bam-1791	208	14	crupi1	crupi1	PROPN
bam-1791	208	15	,	,	PUNCT
bam-1791	208	16	luca	luca	PROPN
bam-1791	208	17	madaro1	madaro1	PROPN
bam-1791	208	18	,	,	PUNCT
bam-1791	208	19	donatella	donatella	NOUN
bam-1791	208	20	starace1	starace1	NOUN
bam-1791	208	21	,	,	PUNCT
bam-1791	208	22	stefania	stefania	NOUN
bam-1791	208	23	rossi2	rossi2	PROPN
bam-1791	208	24	,	,	PUNCT
bam-1791	208	25	mirella	mirella	PROPN
bam-1791	208	26	meregalli3	meregalli3	PROPN
bam-1791	208	27	,	,	PUNCT
bam-1791	208	28	francesco	francesco	PROPN
bam-1791	208	29	facchiano2	facchiano2	PROPN
bam-1791	208	30	,	,	PUNCT
bam-1791	208	31	yvan	yvan	PROPN
bam-1791	208	32	torrente3	torrente3	PROPN
bam-1791	208	33	,	,	PUNCT
bam-1791	208	34	marina	marina	PROPN
bam-1791	208	35	bouchè1	bouchè1	PROPN
bam-1791	208	36	.	.	PUNCT
bam-1791	209	1	1unit	1unit	NUM
bam-1791	209	2	of	of	ADP
bam-1791	209	3	histology	histology	NOUN
bam-1791	209	4	and	and	CCONJ
bam-1791	209	5	medical	medical	ADJ
bam-1791	209	6	embriology	embriology	NOUN
bam-1791	209	7	,	,	PUNCT
bam-1791	209	8	sapienza	sapienza	PROPN
bam-1791	209	9	university	university	PROPN
bam-1791	209	10	,	,	PUNCT
bam-1791	209	11	dahfmo	dahfmo	PROPN
bam-1791	209	12	,	,	PUNCT
bam-1791	209	13	rome	rome	PROPN
bam-1791	209	14	,	,	PUNCT
bam-1791	209	15	italy	italy	PROPN
bam-1791	209	16	.	.	PUNCT
bam-1791	210	1	2department	2department	NUM
bam-1791	210	2	of	of	ADP
bam-1791	210	3	hematology	hematology	NOUN
bam-1791	210	4	,	,	PUNCT
bam-1791	210	5	oncology	oncology	NOUN
bam-1791	210	6	and	and	CCONJ
bam-1791	210	7	molecular	molecular	ADJ
bam-1791	210	8	medicine	medicine	NOUN
bam-1791	210	9	,	,	PUNCT
bam-1791	210	10	istituto	istituto	PROPN
bam-1791	210	11	superiore	superiore	PROPN
bam-1791	210	12	di	di	PROPN
bam-1791	210	13	sanità	sanità	PROPN
bam-1791	210	14	,	,	PUNCT
bam-1791	210	15	rome	rome	PROPN
bam-1791	210	16	,	,	PUNCT
bam-1791	210	17	italy	italy	PROPN
bam-1791	210	18	.	.	PUNCT
bam-1791	211	1	3stem	3stem	NUM
bam-1791	211	2	cell	cell	NOUN
bam-1791	211	3	laboratory	laboratory	NOUN
bam-1791	211	4	,	,	PUNCT
bam-1791	211	5	department	department	NOUN
bam-1791	211	6	of	of	ADP
bam-1791	211	7	pathophysiology	pathophysiology	NOUN
bam-1791	211	8	and	and	CCONJ
bam-1791	211	9	transplantation	transplantation	NOUN
bam-1791	211	10	,	,	PUNCT
bam-1791	211	11	università	università	PROPN
bam-1791	211	12	degli	degli	PROPN
bam-1791	211	13	studi	studi	PROPN
bam-1791	211	14	di	di	X
bam-1791	211	15	milano	milano	PROPN
bam-1791	211	16	,	,	PUNCT
bam-1791	211	17	fondazione	fondazione	PROPN
bam-1791	211	18	irccs	irccs	NOUN
bam-1791	211	19	ca	can	AUX
bam-1791	211	20	'	'	PART
bam-1791	211	21	granda	granda	PROPN
bam-1791	211	22	ospedale	ospedale	PROPN
bam-1791	211	23	maggiore	maggiore	PROPN
bam-1791	211	24	policlinico	policlinico	NOUN
bam-1791	211	25	,	,	PUNCT
bam-1791	211	26	centro	centro	PROPN
bam-1791	211	27	dino	dino	PROPN
bam-1791	211	28	ferrari	ferrari	PROPN
bam-1791	211	29	,	,	PUNCT
bam-1791	211	30	milano	milano	PROPN
bam-1791	211	31	,	,	PUNCT
bam-1791	211	32	italy	italy	PROPN
bam-1791	211	33	.	.	PUNCT
bam-1791	212	1	inflammation	inflammation	NOUN
bam-1791	212	2	is	be	AUX
bam-1791	212	3	an	an	DET
bam-1791	212	4	essential	essential	ADJ
bam-1791	212	5	feature	feature	NOUN
bam-1791	212	6	in	in	ADP
bam-1791	212	7	the	the	DET
bam-1791	212	8	onset	onset	NOUN
bam-1791	212	9	and	and	CCONJ
bam-1791	212	10	progression	progression	NOUN
bam-1791	212	11	of	of	ADP
bam-1791	212	12	muscular	muscular	ADJ
bam-1791	212	13	dystrophy	dystrophy	NOUN
bam-1791	212	14	.	.	PUNCT
bam-1791	213	1	moreover	moreover	ADV
bam-1791	213	2	,	,	PUNCT
bam-1791	213	3	geneand	geneand	PROPN
bam-1791	213	4	cellbased	cellbase	VERB
bam-1791	213	5	therapeutic	therapeutic	ADJ
bam-1791	213	6	approaches	approach	NOUN
bam-1791	213	7	have	have	AUX
bam-1791	213	8	been	be	AUX
bam-1791	213	9	shown	show	VERB
bam-1791	213	10	to	to	PART
bam-1791	213	11	possibly	possibly	ADV
bam-1791	213	12	elicit	elicit	VERB
bam-1791	213	13	t	t	NOUN
bam-1791	213	14	-	-	PUNCT
bam-1791	213	15	cell	cell	NOUN
bam-1791	213	16	immunity	immunity	NOUN
bam-1791	213	17	in	in	ADP
bam-1791	213	18	patients	patient	NOUN
bam-1791	213	19	with	with	ADP
bam-1791	213	20	duchenne	duchenne	PROPN
bam-1791	213	21	’s	’s	PART
bam-1791	213	22	muscular	muscular	ADJ
bam-1791	213	23	dystrophy	dystrophy	NOUN
bam-1791	213	24	.	.	PUNCT
bam-1791	214	1	we	we	PRON
bam-1791	214	2	recently	recently	ADV
bam-1791	214	3	observed	observe	VERB
bam-1791	214	4	that	that	SCONJ
bam-1791	214	5	lack	lack	NOUN
bam-1791	214	6	of	of	ADP
bam-1791	214	7	pkcθ	pkcθ	NOUN
bam-1791	214	8	in	in	ADP
bam-1791	214	9	mdx	mdx	NOUN
bam-1791	214	10	,	,	PUNCT
bam-1791	214	11	greatly	greatly	ADV
bam-1791	214	12	improved	improve	VERB
bam-1791	214	13	muscle	muscle	NOUN
bam-1791	214	14	maintenance	maintenance	NOUN
bam-1791	214	15	,	,	PUNCT
bam-1791	214	16	regeneration	regeneration	NOUN
bam-1791	214	17	and	and	CCONJ
bam-1791	214	18	strength	strength	NOUN
bam-1791	214	19	,	,	PUNCT
bam-1791	214	20	preventing	prevent	VERB
bam-1791	214	21	massive	massive	ADJ
bam-1791	214	22	inflammation	inflammation	NOUN
bam-1791	214	23	and	and	CCONJ
bam-1791	214	24	wasting	waste	VERB
bam-1791	214	25	.	.	PUNCT
bam-1791	215	1	although	although	SCONJ
bam-1791	215	2	pkcθ	pkcθ	PROPN
bam-1791	215	3	is	be	AUX
bam-1791	215	4	expressed	express	VERB
bam-1791	215	5	in	in	ADP
bam-1791	215	6	both	both	DET
bam-1791	215	7	immune	immune	ADJ
bam-1791	215	8	cells	cell	NOUN
bam-1791	215	9	and	and	CCONJ
bam-1791	215	10	skeletal	skeletal	ADJ
bam-1791	215	11	muscle	muscle	NOUN
bam-1791	215	12	,	,	PUNCT
bam-1791	215	13	the	the	DET
bam-1791	215	14	observed	observed	ADJ
bam-1791	215	15	phenotype	phenotype	NOUN
bam-1791	215	16	was	be	AUX
bam-1791	215	17	primarily	primarily	ADV
bam-1791	215	18	due	due	ADJ
bam-1791	215	19	to	to	ADP
bam-1791	215	20	lack	lack	NOUN
bam-1791	215	21	of	of	ADP
bam-1791	215	22	pkcθ	pkcθ	NOUN
bam-1791	215	23	in	in	ADP
bam-1791	215	24	bm	bm	ADJ
bam-1791	215	25	-	-	ADJ
bam-1791	215	26	derived	derive	VERB
bam-1791	215	27	cells	cell	NOUN
bam-1791	215	28	.	.	PUNCT
bam-1791	216	1	however	however	ADV
bam-1791	216	2	,	,	PUNCT
bam-1791	216	3	pkcθ	pkcθ	PROPN
bam-1791	216	4	is	be	AUX
bam-1791	216	5	currently	currently	ADV
bam-1791	216	6	proposed	propose	VERB
bam-1791	216	7	as	as	ADP
bam-1791	216	8	a	a	DET
bam-1791	216	9	target	target	NOUN
bam-1791	216	10	to	to	PART
bam-1791	216	11	selectively	selectively	ADV
bam-1791	216	12	manipulate	manipulate	VERB
bam-1791	216	13	t	t	PROPN
bam-1791	216	14	cell	cell	NOUN
bam-1791	216	15	functions	function	NOUN
bam-1791	216	16	,	,	PUNCT
bam-1791	216	17	promoting	promote	VERB
bam-1791	216	18	the	the	DET
bam-1791	216	19	establishment	establishment	NOUN
bam-1791	216	20	of	of	ADP
bam-1791	216	21	a	a	DET
bam-1791	216	22	regulatory	regulatory	ADJ
bam-1791	216	23	and	and	CCONJ
bam-1791	216	24	immunotolerant	immunotolerant	ADJ
bam-1791	216	25	phenotype	phenotype	NOUN
bam-1791	216	26	.	.	PUNCT
bam-1791	217	1	we	we	PRON
bam-1791	217	2	are	be	AUX
bam-1791	217	3	using	use	VERB
bam-1791	217	4	the	the	DET
bam-1791	217	5	bi	bi	ADJ
bam-1791	217	6	-	-	ADJ
bam-1791	217	7	genetic	genetic	ADJ
bam-1791	217	8	mouse	mouse	NOUN
bam-1791	217	9	model	model	NOUN
bam-1791	217	10	mdx	mdx	PROPN
bam-1791	217	11	/	/	SYM
bam-1791	217	12	θ-/we	θ-/we	PROPN
bam-1791	217	13	generated	generate	VERB
bam-1791	217	14	to	to	PART
bam-1791	217	15	dissect	dissect	VERB
bam-1791	217	16	the	the	DET
bam-1791	217	17	role	role	NOUN
bam-1791	217	18	of	of	ADP
bam-1791	217	19	tcell	tcell	NOUN
bam-1791	217	20	subclasses	subclass	NOUN
bam-1791	217	21	in	in	ADP
bam-1791	217	22	dmd	dmd	NOUN
bam-1791	217	23	,	,	PUNCT
bam-1791	217	24	as	as	ADV
bam-1791	217	25	well	well	ADV
bam-1791	217	26	as	as	ADP
bam-1791	217	27	to	to	PART
bam-1791	217	28	validate	validate	VERB
bam-1791	217	29	targeting	target	VERB
bam-1791	217	30	pkcθ	pkcθ	NOUN
bam-1791	217	31	as	as	ADP
bam-1791	217	32	a	a	DET
bam-1791	217	33	valuable	valuable	ADJ
bam-1791	217	34	approach	approach	NOUN
bam-1791	217	35	to	to	PART
bam-1791	217	36	counteract	counteract	VERB
bam-1791	217	37	disease	disease	NOUN
bam-1791	217	38	progression	progression	NOUN
bam-1791	217	39	.	.	PUNCT
bam-1791	218	1	we	we	PRON
bam-1791	218	2	are	be	AUX
bam-1791	218	3	characterizing	characterize	VERB
bam-1791	218	4	morphology	morphology	NOUN
bam-1791	218	5	,	,	PUNCT
bam-1791	218	6	immune	immune	ADJ
bam-1791	218	7	cell	cell	NOUN
bam-1791	218	8	population	population	NOUN
bam-1791	218	9	composition	composition	NOUN
bam-1791	218	10	,	,	PUNCT
bam-1791	218	11	inflammatory	inflammatory	ADJ
bam-1791	218	12	pathways	pathway	NOUN
bam-1791	218	13	activity	activity	NOUN
bam-1791	218	14	,	,	PUNCT
bam-1791	218	15	cytokyne	cytokyne	NOUN
bam-1791	218	16	/	/	SYM
bam-1791	218	17	chemokines	chemokine	NOUN
bam-1791	218	18	release	release	VERB
bam-1791	218	19	in	in	ADP
bam-1791	218	20	mdx	mdx	NOUN
bam-1791	218	21	/	/	SYM
bam-1791	218	22	θ-/as	θ-/as	NUM
bam-1791	218	23	compared	compare	VERB
bam-1791	218	24	to	to	ADP
bam-1791	218	25	mdx	mdx	NOUN
bam-1791	218	26	mice	mouse	NOUN
bam-1791	218	27	,	,	PUNCT
bam-1791	218	28	at	at	ADP
bam-1791	218	29	different	different	ADJ
bam-1791	218	30	ages	age	NOUN
bam-1791	218	31	.	.	PUNCT
bam-1791	219	1	moreover	moreover	ADV
bam-1791	219	2	,	,	PUNCT
bam-1791	219	3	to	to	PART
bam-1791	219	4	investigate	investigate	VERB
bam-1791	219	5	the	the	DET
bam-1791	219	6	tcell	tcell	NOUN
bam-1791	219	7	dependent	dependent	ADJ
bam-1791	219	8	contribution	contribution	NOUN
bam-1791	219	9	to	to	ADP
bam-1791	219	10	the	the	DET
bam-1791	219	11	pathogenesis	pathogenesis	NOUN
bam-1791	219	12	of	of	ADP
bam-1791	219	13	the	the	DET
bam-1791	219	14	disease	disease	NOUN
bam-1791	219	15	,	,	PUNCT
bam-1791	219	16	we	we	PRON
bam-1791	219	17	transplanted	transplant	VERB
bam-1791	219	18	wt	wt	PROPN
bam-1791	219	19	and	and	CCONJ
bam-1791	219	20	pkcθ-/spleen	pkcθ-/spleen	NUM
bam-1791	219	21	t	t	PROPN
bam-1791	219	22	-	-	PUNCT
bam-1791	219	23	cells	cell	NOUN
bam-1791	219	24	into	into	ADP
bam-1791	219	25	the	the	DET
bam-1791	219	26	immunodeficient	immunodeficient	NOUN
bam-1791	219	27	scid	scid	PROPN
bam-1791	219	28	/	/	SYM
bam-1791	219	29	mdx	mdx	NOUN
bam-1791	219	30	mice	mouse	NOUN
bam-1791	219	31	.	.	PUNCT
bam-1791	220	1	preliminary	preliminary	ADJ
bam-1791	220	2	results	result	NOUN
bam-1791	220	3	demonstrated	demonstrate	VERB
bam-1791	220	4	that	that	SCONJ
bam-1791	220	5	pkcθ	pkcθ	NOUN
bam-1791	220	6	expressing	express	VERB
bam-1791	220	7	t	t	NOUN
bam-1791	220	8	cells	cell	NOUN
bam-1791	220	9	are	be	AUX
bam-1791	220	10	highly	highly	ADV
bam-1791	220	11	and	and	CCONJ
bam-1791	220	12	ix	ix	ADP
bam-1791	220	13	iim	iim	PROPN
bam-1791	220	14	meeting	meeting	NOUN
bam-1791	220	15	,	,	PUNCT
bam-1791	220	16	acaya	acaya	NOUN
bam-1791	220	17	(	(	PUNCT
bam-1791	220	18	lecce	lecce	PROPN
bam-1791	220	19	)	)	PUNCT
bam-1791	220	20	,	,	PUNCT
bam-1791	220	21	october	october	PROPN
bam-1791	220	22	12	12	NUM
bam-1791	220	23	-	-	SYM
bam-1791	220	24	14	14	NUM
bam-1791	220	25	,	,	PUNCT
bam-1791	220	26	2012	2012	NUM
bam-1791	220	27	european	european	PROPN
bam-1791	220	28	journal	journal	PROPN
bam-1791	220	29	translational	translational	ADJ
bam-1791	220	30	myology	myology	NOUN
bam-1791	220	31	basic	basic	ADJ
bam-1791	220	32	applied	apply	VERB
bam-1791	220	33	myology	myology	NOUN
bam-1791	220	34	2012	2012	NUM
bam-1791	220	35	;	;	PUNCT
bam-1791	220	36	22(1&2	22(1&2	NUM
bam-1791	220	37	):	):	PUNCT
bam-1791	220	38	xxx	xxx	NOUN
bam-1791	220	39	-	-	PUNCT
bam-1791	220	40	xxx	xxx	NOUN
bam-1791	220	41	28	28	NUM
bam-1791	220	42	specifically	specifically	ADV
bam-1791	220	43	recruited	recruit	VERB
bam-1791	220	44	into	into	ADP
bam-1791	220	45	dystrophic	dystrophic	ADJ
bam-1791	220	46	muscle	muscle	NOUN
bam-1791	220	47	,	,	PUNCT
bam-1791	220	48	worsening	worsen	VERB
bam-1791	220	49	the	the	DET
bam-1791	220	50	muscle	muscle	NOUN
bam-1791	220	51	phenotype	phenotype	NOUN
bam-1791	220	52	.	.	PUNCT
bam-1791	221	1	moreover	moreover	ADV
bam-1791	221	2	,	,	PUNCT
bam-1791	221	3	we	we	PRON
bam-1791	221	4	observed	observe	VERB
bam-1791	221	5	that	that	SCONJ
bam-1791	221	6	lack	lack	NOUN
bam-1791	221	7	of	of	ADP
bam-1791	221	8	pkcθ	pkcθ	NOUN
bam-1791	221	9	improved	improve	VERB
bam-1791	221	10	t	t	NOUN
bam-1791	221	11	cell	cell	NOUN
bam-1791	221	12	differentiation	differentiation	NOUN
bam-1791	221	13	into	into	ADP
bam-1791	221	14	the	the	DET
bam-1791	221	15	treg	treg	PROPN
bam-1791	221	16	phenotype	phenotype	NOUN
bam-1791	221	17	in	in	ADP
bam-1791	221	18	vitro	vitro	X
bam-1791	221	19	.	.	PUNCT
bam-1791	222	1	taken	take	VERB
bam-1791	222	2	together	together	ADV
bam-1791	222	3	our	our	PRON
bam-1791	222	4	results	result	NOUN
bam-1791	222	5	suggest	suggest	VERB
bam-1791	222	6	that	that	SCONJ
bam-1791	222	7	t	t	PROPN
bam-1791	222	8	-	-	PUNCT
bam-1791	222	9	cells	cell	NOUN
bam-1791	222	10	are	be	AUX
bam-1791	222	11	primarily	primarily	ADV
bam-1791	222	12	involved	involve	VERB
bam-1791	222	13	in	in	ADP
bam-1791	222	14	the	the	DET
bam-1791	222	15	pathogenesis	pathogenesis	NOUN
bam-1791	222	16	of	of	ADP
bam-1791	222	17	dmd	dmd	NOUN
bam-1791	222	18	,	,	PUNCT
bam-1791	222	19	and	and	CCONJ
bam-1791	222	20	that	that	SCONJ
bam-1791	222	21	targeting	target	VERB
bam-1791	222	22	pkcθ	pkcθ	NOUN
bam-1791	222	23	may	may	AUX
bam-1791	222	24	favour	favour	VERB
bam-1791	222	25	the	the	DET
bam-1791	222	26	establishment	establishment	NOUN
bam-1791	222	27	of	of	ADP
bam-1791	222	28	an	an	DET
bam-1791	222	29	immunotolerant	immunotolerant	PROPN
bam-1791	222	30	environment	environment	NOUN
bam-1791	222	31	,	,	PUNCT
bam-1791	222	32	improving	improve	VERB
bam-1791	222	33	muscle	muscle	NOUN
bam-1791	222	34	maintenance	maintenance	NOUN
bam-1791	222	35	.	.	PUNCT
bam-1791	223	1	19	19	NUM
bam-1791	223	2	.	.	X
bam-1791	223	3	exploiting	exploit	VERB
bam-1791	223	4	vasopressin	vasopressin	NOUN
bam-1791	223	5	signaling	signal	VERB
bam-1791	223	6	in	in	ADP
bam-1791	223	7	muscular	muscular	ADJ
bam-1791	223	8	atrophy	atrophy	NOUN
bam-1791	223	9	and	and	CCONJ
bam-1791	223	10	dystrophies	dystrophy	NOUN
bam-1791	223	11	alessandra	alessandra	PROPN
bam-1791	223	12	costa	costa	PROPN
bam-1791	223	13	,	,	PUNCT
bam-1791	223	14	sergio	sergio	PROPN
bam-1791	223	15	adamo	adamo	PROPN
bam-1791	223	16	and	and	CCONJ
bam-1791	223	17	bianca	bianca	PROPN
bam-1791	223	18	maria	maria	PROPN
bam-1791	223	19	scicchitano	scicchitano	PROPN
bam-1791	223	20	dept	dept	PROPN
bam-1791	223	21	.	.	PROPN
bam-1791	224	1	anatomical	anatomical	ADJ
bam-1791	224	2	,	,	PUNCT
bam-1791	224	3	histological	histological	ADJ
bam-1791	224	4	,	,	PUNCT
bam-1791	224	5	forensic	forensic	ADJ
bam-1791	224	6	and	and	CCONJ
bam-1791	224	7	orthopaedic	orthopaedic	ADJ
bam-1791	224	8	sciences	sciences	PROPN
bam-1791	224	9	,	,	PUNCT
bam-1791	224	10	sapienza	sapienza	PROPN
bam-1791	224	11	university	university	PROPN
bam-1791	224	12	of	of	ADP
bam-1791	224	13	rome	rome	PROPN
bam-1791	224	14	arginine	arginine	NOUN
bam-1791	224	15	-	-	PUNCT
bam-1791	224	16	vasopressin	vasopressin	NOUN
bam-1791	224	17	(	(	PUNCT
bam-1791	224	18	avp	avp	PROPN
bam-1791	224	19	)	)	PUNCT
bam-1791	224	20	is	be	AUX
bam-1791	224	21	a	a	DET
bam-1791	224	22	neurohypophyseal	neurohypophyseal	ADJ
bam-1791	224	23	hormone	hormone	NOUN
bam-1791	224	24	able	able	ADJ
bam-1791	224	25	to	to	PART
bam-1791	224	26	induce	induce	VERB
bam-1791	224	27	differentiation	differentiation	NOUN
bam-1791	224	28	in	in	ADP
bam-1791	224	29	myogenic	myogenic	ADJ
bam-1791	224	30	cell	cell	NOUN
bam-1791	224	31	lines	line	NOUN
bam-1791	224	32	and	and	CCONJ
bam-1791	224	33	primary	primary	ADJ
bam-1791	224	34	satellite	satellite	NOUN
bam-1791	224	35	cells	cell	NOUN
bam-1791	224	36	.	.	PUNCT
bam-1791	225	1	v1ar	v1ar	PROPN
bam-1791	225	2	is	be	AUX
bam-1791	225	3	the	the	DET
bam-1791	225	4	only	only	ADJ
bam-1791	225	5	avp	avp	ADJ
bam-1791	225	6	receptor	receptor	NOUN
bam-1791	225	7	expressed	express	VERB
bam-1791	225	8	in	in	ADP
bam-1791	225	9	skeletal	skeletal	ADJ
bam-1791	225	10	muscle	muscle	NOUN
bam-1791	225	11	.	.	PUNCT
bam-1791	226	1	by	by	ADP
bam-1791	226	2	interacting	interact	VERB
bam-1791	226	3	with	with	ADP
bam-1791	226	4	v1ar	v1ar	PROPN
bam-1791	226	5	,	,	PUNCT
bam-1791	226	6	avp	avp	PROPN
bam-1791	226	7	activates	activate	VERB
bam-1791	226	8	phospholipases	phospholipase	NOUN
bam-1791	226	9	c	c	PROPN
bam-1791	226	10	and	and	CCONJ
bam-1791	226	11	d	d	PROPN
bam-1791	226	12	,	,	PUNCT
bam-1791	226	13	increases	increase	VERB
bam-1791	226	14	cytosolic	cytosolic	ADJ
bam-1791	226	15	ca2	ca2	PROPN
bam-1791	226	16	+	+	PROPN
bam-1791	226	17	concentrations	concentration	NOUN
bam-1791	226	18	and	and	CCONJ
bam-1791	226	19	regulates	regulate	VERB
bam-1791	226	20	camp	camp	NOUN
bam-1791	226	21	levels	level	NOUN
bam-1791	226	22	.	.	PUNCT
bam-1791	227	1	the	the	DET
bam-1791	227	2	avpdependent	avpdependent	NOUN
bam-1791	227	3	increase	increase	VERB
bam-1791	227	4	in	in	ADP
bam-1791	227	5	cytosolic	cytosolic	ADJ
bam-1791	227	6	calcium	calcium	NOUN
bam-1791	227	7	activates	activate	VERB
bam-1791	227	8	camk	camk	NOUN
bam-1791	227	9	and	and	CCONJ
bam-1791	227	10	calcineurin	calcineurin	ADJ
bam-1791	227	11	pathways	pathway	NOUN
bam-1791	227	12	resulting	result	VERB
bam-1791	227	13	in	in	ADP
bam-1791	227	14	the	the	DET
bam-1791	227	15	formation	formation	NOUN
bam-1791	227	16	of	of	ADP
bam-1791	227	17	multifactor	multifactor	NOUN
bam-1791	227	18	complexes	complex	NOUN
bam-1791	227	19	on	on	ADP
bam-1791	227	20	the	the	DET
bam-1791	227	21	promoter	promoter	NOUN
bam-1791	227	22	of	of	ADP
bam-1791	227	23	muscle	muscle	NOUN
bam-1791	227	24	specific	specific	ADJ
bam-1791	227	25	genes	gene	NOUN
bam-1791	227	26	.	.	PUNCT
bam-1791	228	1	our	our	PRON
bam-1791	228	2	previous	previous	ADJ
bam-1791	228	3	data	datum	NOUN
bam-1791	228	4	demonstrate	demonstrate	VERB
bam-1791	228	5	that	that	SCONJ
bam-1791	228	6	v1ar	v1ar	PUNCT
bam-1791	228	7	expression	expression	NOUN
bam-1791	228	8	is	be	AUX
bam-1791	228	9	modulated	modulate	VERB
bam-1791	228	10	during	during	ADP
bam-1791	228	11	muscle	muscle	NOUN
bam-1791	228	12	regeneration	regeneration	NOUN
bam-1791	228	13	and	and	CCONJ
bam-1791	228	14	the	the	DET
bam-1791	228	15	stimulation	stimulation	NOUN
bam-1791	228	16	of	of	ADP
bam-1791	228	17	avp	avp	NOUN
bam-1791	228	18	signaling	signal	VERB
bam-1791	228	19	strongly	strongly	ADV
bam-1791	228	20	enhances	enhance	VERB
bam-1791	228	21	regeneration	regeneration	NOUN
bam-1791	228	22	of	of	ADP
bam-1791	228	23	injured	injure	VERB
bam-1791	228	24	muscles	muscle	NOUN
bam-1791	228	25	.	.	PUNCT
bam-1791	229	1	in	in	ADP
bam-1791	229	2	an	an	DET
bam-1791	229	3	experimental	experimental	ADJ
bam-1791	229	4	model	model	NOUN
bam-1791	229	5	of	of	ADP
bam-1791	229	6	muscular	muscular	ADJ
bam-1791	229	7	atrophy	atrophy	NOUN
bam-1791	229	8	induced	induce	VERB
bam-1791	229	9	by	by	ADP
bam-1791	229	10	tnf	tnf	PROPN
bam-1791	229	11	over	over	ADP
bam-1791	229	12	-	-	PUNCT
bam-1791	229	13	expression	expression	NOUN
bam-1791	229	14	,	,	PUNCT
bam-1791	229	15	stimulation	stimulation	NOUN
bam-1791	229	16	of	of	ADP
bam-1791	229	17	avp	avp	PROPN
bam-1791	229	18	pathways	pathway	NOUN
bam-1791	229	19	counteracts	counteract	VERB
bam-1791	229	20	the	the	DET
bam-1791	229	21	negative	negative	ADJ
bam-1791	229	22	effects	effect	NOUN
bam-1791	229	23	of	of	ADP
bam-1791	229	24	tnf	tnf	PROPN
bam-1791	229	25	both	both	PRON
bam-1791	229	26	enhancing	enhance	VERB
bam-1791	229	27	regeneration	regeneration	NOUN
bam-1791	229	28	and	and	CCONJ
bam-1791	229	29	inhibiting	inhibit	VERB
bam-1791	229	30	inflammation	inflammation	NOUN
bam-1791	229	31	.	.	PUNCT
bam-1791	230	1	the	the	DET
bam-1791	230	2	molecular	molecular	ADJ
bam-1791	230	3	analysis	analysis	NOUN
bam-1791	230	4	for	for	ADP
bam-1791	230	5	the	the	DET
bam-1791	230	6	expression	expression	NOUN
bam-1791	230	7	levels	level	NOUN
bam-1791	230	8	of	of	ADP
bam-1791	230	9	early	early	ADJ
bam-1791	230	10	and	and	CCONJ
bam-1791	230	11	late	late	ADJ
bam-1791	230	12	regeneration	regeneration	NOUN
bam-1791	230	13	markers	marker	NOUN
bam-1791	230	14	(	(	PUNCT
bam-1791	230	15	pax7	pax7	NOUN
bam-1791	230	16	and	and	CCONJ
bam-1791	230	17	myod	myod	NOUN
bam-1791	230	18	or	or	CCONJ
bam-1791	230	19	myogenin	myogenin	ADJ
bam-1791	230	20	and	and	CCONJ
bam-1791	230	21	mhc	mhc	PROPN
bam-1791	230	22	,	,	PUNCT
bam-1791	230	23	respectively	respectively	ADV
bam-1791	230	24	)	)	PUNCT
bam-1791	230	25	suggested	suggest	VERB
bam-1791	230	26	an	an	DET
bam-1791	230	27	impairment	impairment	NOUN
bam-1791	230	28	of	of	ADP
bam-1791	230	29	regeneration	regeneration	NOUN
bam-1791	230	30	in	in	ADP
bam-1791	230	31	muscles	muscle	NOUN
bam-1791	230	32	over	over	ADP
bam-1791	230	33	-	-	PUNCT
bam-1791	230	34	expressing	express	VERB
bam-1791	230	35	tnf	tnf	PROPN
bam-1791	230	36	.	.	PUNCT
bam-1791	231	1	this	this	DET
bam-1791	231	2	effect	effect	NOUN
bam-1791	231	3	was	be	AUX
bam-1791	231	4	counteracted	counteract	VERB
bam-1791	231	5	by	by	ADP
bam-1791	231	6	v1ar	v1ar	X
bam-1791	231	7	overexpression	overexpression	NOUN
bam-1791	231	8	.	.	PUNCT
bam-1791	232	1	the	the	DET
bam-1791	232	2	positive	positive	ADJ
bam-1791	232	3	effects	effect	NOUN
bam-1791	232	4	of	of	ADP
bam-1791	232	5	v1ar	v1ar	NOUN
bam-1791	232	6	on	on	ADP
bam-1791	232	7	muscle	muscle	NOUN
bam-1791	232	8	homeostasis	homeostasis	NOUN
bam-1791	232	9	are	be	AUX
bam-1791	232	10	due	due	ADJ
bam-1791	232	11	to	to	ADP
bam-1791	232	12	the	the	DET
bam-1791	232	13	promotion	promotion	NOUN
bam-1791	232	14	of	of	ADP
bam-1791	232	15	the	the	DET
bam-1791	232	16	calcinuerin	calcinuerin	NOUN
bam-1791	232	17	-	-	PUNCT
bam-1791	232	18	il-4	il-4	NOUN
bam-1791	232	19	pathway	pathway	NOUN
bam-1791	232	20	and	and	CCONJ
bam-1791	232	21	by	by	ADP
bam-1791	232	22	the	the	DET
bam-1791	232	23	inhibition	inhibition	NOUN
bam-1791	232	24	of	of	ADP
bam-1791	232	25	atrophic	atrophic	ADJ
bam-1791	232	26	genes	gene	NOUN
bam-1791	232	27	expression	expression	NOUN
bam-1791	232	28	mediated	mediate	VERB
bam-1791	232	29	by	by	ADP
bam-1791	232	30	foxo	foxo	ADJ
bam-1791	232	31	phosphorylation	phosphorylation	NOUN
bam-1791	232	32	via	via	ADP
bam-1791	232	33	akt	akt	PROPN
bam-1791	232	34	-	-	PUNCT
bam-1791	232	35	dependant	dependant	ADJ
bam-1791	232	36	pathway	pathway	NOUN
bam-1791	232	37	.	.	PUNCT
bam-1791	233	1	by	by	ADP
bam-1791	233	2	all	all	DET
bam-1791	233	3	the	the	DET
bam-1791	233	4	above	above	ADV
bam-1791	233	5	we	we	PRON
bam-1791	233	6	are	be	AUX
bam-1791	233	7	analyzing	analyze	VERB
bam-1791	233	8	the	the	DET
bam-1791	233	9	effects	effect	NOUN
bam-1791	233	10	of	of	ADP
bam-1791	233	11	avp	avp	NOUN
bam-1791	233	12	signaling	signal	VERB
bam-1791	233	13	stimulation	stimulation	NOUN
bam-1791	233	14	in	in	ADP
bam-1791	233	15	mouse	mouse	NOUN
bam-1791	233	16	models	model	NOUN
bam-1791	233	17	of	of	ADP
bam-1791	233	18	muscular	muscular	ADJ
bam-1791	233	19	dystrophies	dystrophy	NOUN
bam-1791	233	20	.	.	PUNCT
bam-1791	234	1	preliminary	preliminary	ADJ
bam-1791	234	2	data	datum	NOUN
bam-1791	234	3	demonstrate	demonstrate	VERB
bam-1791	234	4	that	that	SCONJ
bam-1791	234	5	stimulation	stimulation	NOUN
bam-1791	234	6	of	of	ADP
bam-1791	234	7	avp	avp	ADJ
bam-1791	234	8	-	-	PUNCT
bam-1791	234	9	dependent	dependent	ADJ
bam-1791	234	10	pathways	pathway	NOUN
bam-1791	234	11	ameliorates	ameliorate	VERB
bam-1791	234	12	inflammation	inflammation	NOUN
bam-1791	234	13	and	and	CCONJ
bam-1791	234	14	regeneration	regeneration	NOUN
bam-1791	234	15	processes	process	NOUN
bam-1791	234	16	.	.	PUNCT
bam-1791	235	1	this	this	DET
bam-1791	235	2	study	study	NOUN
bam-1791	235	3	highlights	highlight	VERB
bam-1791	235	4	a	a	DET
bam-1791	235	5	novel	novel	NOUN
bam-1791	235	6	in	in	ADP
bam-1791	235	7	vivo	vivo	ADJ
bam-1791	235	8	role	role	NOUN
bam-1791	235	9	for	for	ADP
bam-1791	235	10	the	the	DET
bam-1791	235	11	avp	avp	ADJ
bam-1791	235	12	-	-	PUNCT
bam-1791	235	13	dependent	dependent	ADJ
bam-1791	235	14	pathways	pathway	NOUN
bam-1791	235	15	which	which	PRON
bam-1791	235	16	may	may	AUX
bam-1791	235	17	represent	represent	VERB
bam-1791	235	18	a	a	DET
bam-1791	235	19	potential	potential	ADJ
bam-1791	235	20	gene	gene	NOUN
bam-1791	235	21	therapy	therapy	NOUN
bam-1791	235	22	approach	approach	NOUN
bam-1791	235	23	for	for	ADP
bam-1791	235	24	many	many	ADJ
bam-1791	235	25	diseases	disease	NOUN
bam-1791	235	26	affecting	affect	VERB
bam-1791	235	27	muscle	muscle	NOUN
bam-1791	235	28	homeostasis	homeostasis	NOUN
bam-1791	235	29	.	.	PUNCT
bam-1791	236	1	session	session	NOUN
bam-1791	236	2	4	4	NUM
bam-1791	236	3	e	e	NOUN
bam-1791	236	4	-	-	NOUN
bam-1791	236	5	c	c	ADJ
bam-1791	236	6	coupling	coupling	NOUN
bam-1791	236	7	in	in	ADP
bam-1791	236	8	health	health	NOUN
bam-1791	236	9	and	and	CCONJ
bam-1791	236	10	diseases	disease	NOUN
bam-1791	236	11	20	20	NUM
bam-1791	236	12	.	.	PUNCT
bam-1791	237	1	the	the	DET
bam-1791	237	2	neuronal	neuronal	ADJ
bam-1791	237	3	growth	growth	NOUN
bam-1791	237	4	associated	associate	VERB
bam-1791	237	5	protein	protein	NOUN
bam-1791	237	6	43	43	NUM
bam-1791	237	7	is	be	AUX
bam-1791	237	8	expressed	express	VERB
bam-1791	237	9	in	in	ADP
bam-1791	237	10	skeletal	skeletal	ADJ
bam-1791	237	11	muscle	muscle	NOUN
bam-1791	237	12	fibers	fiber	NOUN
bam-1791	237	13	close	close	ADJ
bam-1791	237	14	to	to	ADP
bam-1791	237	15	mitochondria	mitochondria	NOUN
bam-1791	237	16	and	and	CCONJ
bam-1791	237	17	calcium	calcium	NOUN
bam-1791	237	18	release	release	NOUN
bam-1791	237	19	units	unit	NOUN
bam-1791	237	20	simone	simone	PROPN
bam-1791	237	21	guarnieri	guarnieri	PROPN
bam-1791	237	22	,	,	PUNCT
bam-1791	237	23	giusy	giusy	NOUN
bam-1791	237	24	caprara	caprara	PROPN
bam-1791	237	25	,	,	PUNCT
bam-1791	237	26	caterina	caterina	PROPN
bam-1791	237	27	morabito	morabito	PROPN
bam-1791	237	28	,	,	PUNCT
bam-1791	237	29	simona	simona	PROPN
bam-1791	237	30	boncompagni	boncompagni	NOUN
bam-1791	237	31	,	,	PUNCT
bam-1791	237	32	cecilia	cecilia	PROPN
bam-1791	237	33	paolini	paolini	PROPN
bam-1791	237	34	,	,	PUNCT
bam-1791	237	35	giorgio	giorgio	PROPN
bam-1791	237	36	fanò	fanò	PROPN
bam-1791	237	37	-	-	PUNCT
bam-1791	237	38	illic	illic	NOUN
bam-1791	237	39	,	,	PUNCT
bam-1791	237	40	maria	maria	PROPN
bam-1791	237	41	a.	a.	NOUN
bam-1791	237	42	mariggiò	mariggiò	PROPN
bam-1791	237	43	.	.	PUNCT
bam-1791	238	1	dept	dept	PROPN
bam-1791	238	2	.	.	PROPN
bam-1791	239	1	neuroscience	neuroscience	PROPN
bam-1791	239	2	and	and	CCONJ
bam-1791	239	3	imaging	imaging	NOUN
bam-1791	239	4	–	–	PUNCT
bam-1791	239	5	ce.s.i	ce.s.i	NOUN
bam-1791	239	6	.	.	PROPN
bam-1791	239	7	,	,	PUNCT
bam-1791	239	8	g.d’annunzio	g.d’annunzio	PROPN
bam-1791	239	9	university	university	PROPN
bam-1791	239	10	,	,	PUNCT
bam-1791	239	11	chieti	chieti	PROPN
bam-1791	239	12	-	-	PUNCT
bam-1791	239	13	pescara	pescara	PROPN
bam-1791	239	14	,	,	PUNCT
bam-1791	239	15	italy	italy	PROPN
bam-1791	239	16	the	the	DET
bam-1791	239	17	neuronal	neuronal	ADJ
bam-1791	239	18	growth	growth	NOUN
bam-1791	239	19	associated	associate	VERB
bam-1791	239	20	protein	protein	NOUN
bam-1791	239	21	43	43	NUM
bam-1791	239	22	(	(	PUNCT
bam-1791	239	23	gap43	gap43	NOUN
bam-1791	239	24	)	)	PUNCT
bam-1791	239	25	,	,	PUNCT
bam-1791	239	26	is	be	AUX
bam-1791	239	27	involved	involve	VERB
bam-1791	239	28	in	in	ADP
bam-1791	239	29	mechanisms	mechanism	NOUN
bam-1791	239	30	controlling	control	VERB
bam-1791	239	31	pathfinding	pathfinding	NOUN
bam-1791	239	32	and	and	CCONJ
bam-1791	239	33	branching	branching	NOUN
bam-1791	239	34	of	of	ADP
bam-1791	239	35	neurons	neuron	NOUN
bam-1791	239	36	during	during	ADP
bam-1791	239	37	development	development	NOUN
bam-1791	239	38	and	and	CCONJ
bam-1791	239	39	regeneration	regeneration	NOUN
bam-1791	239	40	.	.	PUNCT
bam-1791	240	1	for	for	ADP
bam-1791	240	2	many	many	ADJ
bam-1791	240	3	years	year	NOUN
bam-1791	240	4	this	this	DET
bam-1791	240	5	protein	protein	NOUN
bam-1791	240	6	was	be	AUX
bam-1791	240	7	classified	classify	VERB
bam-1791	240	8	as	as	ADP
bam-1791	240	9	neuronspecific	neuronspecific	NOUN
bam-1791	240	10	,	,	PUNCT
bam-1791	240	11	but	but	CCONJ
bam-1791	240	12	recent	recent	ADJ
bam-1791	240	13	evidences	evidence	NOUN
bam-1791	240	14	suggest	suggest	VERB
bam-1791	240	15	that	that	SCONJ
bam-1791	240	16	gap43	gap43	NOUN
bam-1791	240	17	is	be	AUX
bam-1791	240	18	expressed	express	VERB
bam-1791	240	19	not	not	PART
bam-1791	240	20	only	only	ADV
bam-1791	240	21	in	in	ADP
bam-1791	240	22	neurons	neuron	NOUN
bam-1791	240	23	,	,	PUNCT
bam-1791	240	24	but	but	CCONJ
bam-1791	240	25	also	also	ADV
bam-1791	240	26	in	in	ADP
bam-1791	240	27	glial	glial	ADJ
bam-1791	240	28	cells	cell	NOUN
bam-1791	240	29	and	and	CCONJ
bam-1791	240	30	in	in	ADP
bam-1791	240	31	muscles	muscle	NOUN
bam-1791	240	32	from	from	ADP
bam-1791	240	33	patients	patient	NOUN
bam-1791	240	34	affected	affect	VERB
bam-1791	240	35	by	by	ADP
bam-1791	240	36	various	various	ADJ
bam-1791	240	37	myopathies	myopathy	NOUN
bam-1791	240	38	.	.	PUNCT
bam-1791	241	1	we	we	PRON
bam-1791	241	2	have	have	AUX
bam-1791	241	3	investigated	investigate	VERB
bam-1791	241	4	the	the	DET
bam-1791	241	5	expression	expression	NOUN
bam-1791	241	6	and	and	CCONJ
bam-1791	241	7	subcellular	subcellular	ADJ
bam-1791	241	8	localization	localization	NOUN
bam-1791	241	9	of	of	ADP
bam-1791	241	10	gap43	gap43	PROPN
bam-1791	241	11	in	in	ADP
bam-1791	241	12	mouse	mouse	NOUN
bam-1791	241	13	satellite	satellite	NOUN
bam-1791	241	14	cells	cell	NOUN
bam-1791	241	15	,	,	PUNCT
bam-1791	241	16	myotubes	myotube	NOUN
bam-1791	241	17	,	,	PUNCT
bam-1791	241	18	and	and	CCONJ
bam-1791	241	19	adult	adult	NOUN
bam-1791	241	20	muscle	muscle	NOUN
bam-1791	241	21	(	(	PUNCT
bam-1791	241	22	extensor	extensor	PROPN
bam-1791	241	23	digitorum	digitorum	PROPN
bam-1791	241	24	longus	longus	PROPN
bam-1791	241	25	or	or	CCONJ
bam-1791	241	26	edl	edl	PROPN
bam-1791	241	27	)	)	PUNCT
bam-1791	241	28	using	use	VERB
bam-1791	241	29	western	western	ADJ
bam-1791	241	30	blotting	blotting	ADJ
bam-1791	241	31	,	,	PUNCT
bam-1791	241	32	immuno	immuno	ADJ
bam-1791	241	33	-	-	NOUN
bam-1791	241	34	fluorescence	fluorescence	NOUN
bam-1791	241	35	in	in	ADP
bam-1791	241	36	confocal	confocal	ADJ
bam-1791	241	37	microscopy	microscopy	NOUN
bam-1791	241	38	and	and	CCONJ
bam-1791	241	39	electron	electron	NOUN
bam-1791	241	40	microscopy	microscopy	NOUN
bam-1791	241	41	(	(	PUNCT
bam-1791	241	42	em	em	PRON
bam-1791	241	43	)	)	PUNCT
bam-1791	241	44	.	.	PUNCT
bam-1791	242	1	our	our	PRON
bam-1791	242	2	results	result	NOUN
bam-1791	242	3	indicated	indicate	VERB
bam-1791	242	4	that	that	SCONJ
bam-1791	242	5	gap43	gap43	NOUN
bam-1791	242	6	is	be	AUX
bam-1791	242	7	indeed	indeed	ADV
bam-1791	242	8	expressed	express	VERB
bam-1791	242	9	in	in	ADP
bam-1791	242	10	both	both	DET
bam-1791	242	11	myoblasts	myoblast	NOUN
bam-1791	242	12	and	and	CCONJ
bam-1791	242	13	differentiating	differentiate	VERB
bam-1791	242	14	myotubes	myotube	NOUN
bam-1791	242	15	,	,	PUNCT
bam-1791	242	16	and	and	CCONJ
bam-1791	242	17	its	its	PRON
bam-1791	242	18	cellular	cellular	ADJ
bam-1791	242	19	localization	localization	NOUN
bam-1791	242	20	changes	change	VERB
bam-1791	242	21	dramatically	dramatically	ADV
bam-1791	242	22	during	during	ADP
bam-1791	242	23	maturation	maturation	NOUN
bam-1791	242	24	:	:	PUNCT
bam-1791	242	25	in	in	ADP
bam-1791	242	26	myoblasts	myoblast	NOUN
bam-1791	242	27	the	the	DET
bam-1791	242	28	localization	localization	NOUN
bam-1791	242	29	appeared	appear	VERB
bam-1791	242	30	to	to	PART
bam-1791	242	31	be	be	AUX
bam-1791	242	32	mostly	mostly	ADV
bam-1791	242	33	nuclear	nuclear	ADJ
bam-1791	242	34	,	,	PUNCT
bam-1791	242	35	whereas	whereas	SCONJ
bam-1791	242	36	with	with	ADP
bam-1791	242	37	differentiation	differentiation	NOUN
bam-1791	242	38	the	the	DET
bam-1791	242	39	protein	protein	NOUN
bam-1791	242	40	started	start	VERB
bam-1791	242	41	to	to	PART
bam-1791	242	42	display	display	VERB
bam-1791	242	43	a	a	DET
bam-1791	242	44	sarcomeric	sarcomeric	ADJ
bam-1791	242	45	-	-	PUNCT
bam-1791	242	46	like	like	ADJ
bam-1791	242	47	pattern	pattern	NOUN
bam-1791	242	48	.	.	PUNCT
bam-1791	243	1	in	in	ADP
bam-1791	243	2	adult	adult	NOUN
bam-1791	243	3	fibers	fiber	NOUN
bam-1791	243	4	,	,	PUNCT
bam-1791	243	5	gap43	gap43	NOUN
bam-1791	243	6	expression	expression	NOUN
bam-1791	243	7	was	be	AUX
bam-1791	243	8	evident	evident	ADJ
bam-1791	243	9	with	with	ADP
bam-1791	243	10	the	the	DET
bam-1791	243	11	protein	protein	NOUN
bam-1791	243	12	labeling	labeling	NOUN
bam-1791	243	13	forming	form	VERB
bam-1791	243	14	(	(	PUNCT
bam-1791	243	15	in	in	ADP
bam-1791	243	16	longitudinal	longitudinal	ADJ
bam-1791	243	17	views	view	NOUN
bam-1791	243	18	)	)	PUNCT
bam-1791	243	19	a	a	DET
bam-1791	243	20	double	double	ADJ
bam-1791	243	21	cross	cross	NOUN
bam-1791	243	22	striation	striation	NOUN
bam-1791	243	23	reminiscent	reminiscent	ADJ
bam-1791	243	24	of	of	ADP
bam-1791	243	25	the	the	DET
bam-1791	243	26	staining	stain	VERB
bam-1791	243	27	pattern	pattern	NOUN
bam-1791	243	28	of	of	ADP
bam-1791	243	29	other	other	ADJ
bam-1791	243	30	organelles	organelle	NOUN
bam-1791	243	31	,	,	PUNCT
bam-1791	243	32	such	such	ADJ
bam-1791	243	33	as	as	ADP
bam-1791	243	34	calcium	calcium	NOUN
bam-1791	243	35	release	release	NOUN
bam-1791	243	36	units	unit	NOUN
bam-1791	243	37	(	(	PUNCT
bam-1791	243	38	crus	crus	NOUN
bam-1791	243	39	)	)	PUNCT
bam-1791	243	40	and	and	CCONJ
bam-1791	243	41	mitochondria	mitochondria	PROPN
bam-1791	243	42	.	.	PUNCT
bam-1791	244	1	experiments	experiment	NOUN
bam-1791	244	2	done	do	VERB
bam-1791	244	3	in	in	ADP
bam-1791	244	4	edl	edl	PROPN
bam-1791	244	5	muscles	muscle	NOUN
bam-1791	244	6	fixed	fix	VERB
bam-1791	244	7	at	at	ADP
bam-1791	244	8	different	different	ADJ
bam-1791	244	9	sarcomere	sarcomere	ADJ
bam-1791	244	10	lengths	length	NOUN
bam-1791	244	11	using	use	VERB
bam-1791	244	12	confocal	confocal	ADJ
bam-1791	244	13	microscopy	microscopy	NOUN
bam-1791	244	14	and	and	CCONJ
bam-1791	244	15	em	em	PRON
bam-1791	244	16	,	,	PUNCT
bam-1791	244	17	revealed	reveal	VERB
bam-1791	244	18	the	the	DET
bam-1791	244	19	localization	localization	NOUN
bam-1791	244	20	,	,	PUNCT
bam-1791	244	21	from	from	ADP
bam-1791	244	22	the	the	DET
bam-1791	244	23	sarcomere	sarcomere	ADJ
bam-1791	244	24	z	z	NOUN
bam-1791	244	25	-	-	PUNCT
bam-1791	244	26	line	line	NOUN
bam-1791	244	27	,	,	PUNCT
bam-1791	244	28	of	of	ADP
bam-1791	244	29	gap43	gap43	ADJ
bam-1791	244	30	positive	positive	ADJ
bam-1791	244	31	foci	focus	NOUN
bam-1791	244	32	,	,	PUNCT
bam-1791	244	33	falling	fall	VERB
bam-1791	244	34	between	between	ADP
bam-1791	244	35	that	that	PRON
bam-1791	244	36	of	of	ADP
bam-1791	244	37	crus	crus	NOUN
bam-1791	244	38	and	and	CCONJ
bam-1791	244	39	of	of	ADP
bam-1791	244	40	mitochondria	mitochondria	NOUN
bam-1791	244	41	.	.	PUNCT
bam-1791	245	1	preliminary	preliminary	ADJ
bam-1791	245	2	results	result	NOUN
bam-1791	245	3	from	from	ADP
bam-1791	245	4	grip	grip	NOUN
bam-1791	245	5	test	test	NOUN
bam-1791	245	6	,	,	PUNCT
bam-1791	245	7	revealed	reveal	VERB
bam-1791	245	8	gender	gender	NOUN
bam-1791	245	9	dependent	dependent	ADJ
bam-1791	245	10	differences	difference	NOUN
bam-1791	245	11	on	on	ADP
bam-1791	245	12	force	force	NOUN
bam-1791	245	13	development	development	NOUN
bam-1791	245	14	on	on	ADP
bam-1791	245	15	gap43	gap43	ADJ
bam-1791	245	16	heterozygous	heterozygous	ADJ
bam-1791	245	17	mice	mouse	NOUN
bam-1791	245	18	.	.	PUNCT
bam-1791	246	1	these	these	DET
bam-1791	246	2	data	datum	NOUN
bam-1791	246	3	lead	lead	VERB
bam-1791	246	4	the	the	DET
bam-1791	246	5	way	way	NOUN
bam-1791	246	6	to	to	ADP
bam-1791	246	7	further	further	ADJ
bam-1791	246	8	investigation	investigation	NOUN
bam-1791	246	9	about	about	ADP
bam-1791	246	10	the	the	DET
bam-1791	246	11	possible	possible	ADJ
bam-1791	246	12	physiological	physiological	ADJ
bam-1791	246	13	and	and	CCONJ
bam-1791	246	14	structural	structural	ADJ
bam-1791	246	15	roles	role	NOUN
bam-1791	246	16	of	of	ADP
bam-1791	246	17	gap43	gap43	NOUN
bam-1791	246	18	protein	protein	NOUN
bam-1791	246	19	in	in	ADP
bam-1791	246	20	adult	adult	NOUN
bam-1791	246	21	fiber	fiber	NOUN
bam-1791	246	22	function	function	NOUN
bam-1791	246	23	and	and	CCONJ
bam-1791	246	24	disease	disease	NOUN
bam-1791	246	25	.	.	PUNCT
bam-1791	247	1	ix	ix	PROPN
bam-1791	247	2	iim	iim	PROPN
bam-1791	247	3	meeting	meeting	NOUN
bam-1791	247	4	,	,	PUNCT
bam-1791	247	5	acaya	acaya	NOUN
bam-1791	247	6	(	(	PUNCT
bam-1791	247	7	lecce	lecce	PROPN
bam-1791	247	8	)	)	PUNCT
bam-1791	247	9	,	,	PUNCT
bam-1791	247	10	october	october	PROPN
bam-1791	247	11	12	12	NUM
bam-1791	247	12	-	-	SYM
bam-1791	247	13	14	14	NUM
bam-1791	247	14	,	,	PUNCT
bam-1791	247	15	2012	2012	NUM
bam-1791	247	16	european	european	PROPN
bam-1791	247	17	journal	journal	PROPN
bam-1791	247	18	translational	translational	ADJ
bam-1791	247	19	myology	myology	NOUN
bam-1791	247	20	basic	basic	ADJ
bam-1791	247	21	applied	apply	VERB
bam-1791	247	22	myology	myology	NOUN
bam-1791	247	23	2012	2012	NUM
bam-1791	247	24	;	;	PUNCT
bam-1791	247	25	22(1&2	22(1&2	NUM
bam-1791	247	26	):	):	PUNCT
bam-1791	247	27	xxx	xxx	NOUN
bam-1791	247	28	-	-	PUNCT
bam-1791	247	29	xxx	xxx	NOUN
bam-1791	247	30	29	29	NUM
bam-1791	247	31	21	21	NUM
bam-1791	247	32	.	.	PUNCT
bam-1791	248	1	post	post	ADJ
bam-1791	248	2	-	-	ADJ
bam-1791	248	3	natal	natal	ADJ
bam-1791	248	4	development	development	NOUN
bam-1791	248	5	of	of	ADP
bam-1791	248	6	sarcoplasmic	sarcoplasmic	ADJ
bam-1791	248	7	reticulum	reticulum	NOUN
bam-1791	248	8	in	in	ADP
bam-1791	248	9	fast	fast	ADJ
bam-1791	248	10	-	-	PUNCT
bam-1791	248	11	twitch	twitch	ADJ
bam-1791	248	12	skeletal	skeletal	ADJ
bam-1791	248	13	muscles	muscle	NOUN
bam-1791	248	14	:	:	PUNCT
bam-1791	248	15	a	a	DET
bam-1791	248	16	pivotal	pivotal	ADJ
bam-1791	248	17	role	role	NOUN
bam-1791	248	18	for	for	ADP
bam-1791	248	19	calsequestrin1	calsequestrin1	NOUN
bam-1791	248	20	.	.	PUNCT
bam-1791	249	1	m.	m.	PROPN
bam-1791	249	2	tomasi	tomasi	PROPN
bam-1791	249	3	*	*	PROPN
bam-1791	249	4	,	,	PUNCT
bam-1791	249	5	s.	s.	PROPN
bam-1791	249	6	furlan	furlan	PROPN
bam-1791	249	7	*	*	PROPN
bam-1791	249	8	,	,	PUNCT
bam-1791	249	9	f.	f.	PROPN
bam-1791	249	10	protasi	protasi	PROPN
bam-1791	249	11	#	#	PROPN
bam-1791	249	12	,	,	PUNCT
bam-1791	249	13	p.	p.	PROPN
bam-1791	249	14	volpe	volpe	PROPN
bam-1791	250	1	*	*	PROPN
bam-1791	250	2	,	,	PUNCT
bam-1791	250	3	a.	a.	PROPN
bam-1791	250	4	nori	nori	PROPN
bam-1791	250	5	*	*	PUNCT
bam-1791	250	6	*	*	PUNCT
bam-1791	250	7	dipartimento	dipartimento	ADP
bam-1791	250	8	scienze	scienze	PROPN
bam-1791	250	9	biomediche	biomediche	PROPN
bam-1791	250	10	università	università	PROPN
bam-1791	250	11	di	di	PROPN
bam-1791	250	12	padova	padova	PROPN
bam-1791	250	13	#	#	PROPN
bam-1791	250	14	cesi	cesi	PROPN
bam-1791	250	15	-	-	PUNCT
bam-1791	250	16	centro	centro	PROPN
bam-1791	250	17	scienze	scienze	PROPN
bam-1791	250	18	dell'invecchiamento	dell'invecchiamento	PROPN
bam-1791	250	19	&	&	CCONJ
bam-1791	250	20	dnidepartment	dnidepartment	NOUN
bam-1791	250	21	of	of	ADP
bam-1791	250	22	neuroscience	neuroscience	NOUN
bam-1791	250	23	and	and	CCONJ
bam-1791	250	24	imaging	imaging	NOUN
bam-1791	250	25	università	università	PROPN
bam-1791	250	26	gabriele	gabriele	PROPN
bam-1791	250	27	d'annunzio	d'annunzio	PROPN
bam-1791	250	28	,	,	PUNCT
bam-1791	250	29	chieti	chieti	PROPN
bam-1791	250	30	.	.	PUNCT
bam-1791	251	1	transition	transition	NOUN
bam-1791	251	2	in	in	ADP
bam-1791	251	3	molecular	molecular	ADJ
bam-1791	251	4	composition	composition	NOUN
bam-1791	251	5	of	of	ADP
bam-1791	251	6	fast	fast	ADJ
bam-1791	251	7	-	-	PUNCT
bam-1791	251	8	twitch	twitch	NOUN
bam-1791	251	9	skeletal	skeletal	ADJ
bam-1791	251	10	muscles	muscle	NOUN
bam-1791	251	11	takes	take	VERB
bam-1791	251	12	place	place	NOUN
bam-1791	251	13	to	to	PART
bam-1791	251	14	accommodate	accommodate	VERB
bam-1791	251	15	specific	specific	ADJ
bam-1791	251	16	functional	functional	ADJ
bam-1791	251	17	requests	request	NOUN
bam-1791	251	18	.	.	PUNCT
bam-1791	252	1	the	the	DET
bam-1791	252	2	sarcoplasmic	sarcoplasmic	NOUN
bam-1791	252	3	reticulum	reticulum	NOUN
bam-1791	252	4	(	(	PUNCT
bam-1791	252	5	sr	sr	PROPN
bam-1791	252	6	)	)	PUNCT
bam-1791	252	7	,	,	PUNCT
bam-1791	252	8	in	in	ADP
bam-1791	252	9	early	early	ADJ
bam-1791	252	10	stages	stage	NOUN
bam-1791	252	11	of	of	ADP
bam-1791	252	12	development	development	NOUN
bam-1791	252	13	,	,	PUNCT
bam-1791	252	14	expresses	express	VERB
bam-1791	252	15	a	a	DET
bam-1791	252	16	variety	variety	NOUN
bam-1791	252	17	of	of	ADP
bam-1791	252	18	slow	slow	ADJ
bam-1791	252	19	/	/	SYM
bam-1791	252	20	cardiac/	cardiac/	NUM
bam-1791	252	21	isoforms	isoform	NOUN
bam-1791	252	22	.	.	PUNCT
bam-1791	253	1	in	in	ADP
bam-1791	253	2	edl	edl	PROPN
bam-1791	253	3	(	(	PUNCT
bam-1791	253	4	extensor	extensor	PROPN
bam-1791	253	5	digitorum	digitorum	PROPN
bam-1791	253	6	longus	longus	PROPN
bam-1791	253	7	)	)	PUNCT
bam-1791	253	8	,	,	PUNCT
bam-1791	253	9	slow	slow	ADJ
bam-1791	253	10	isoforms	isoform	NOUN
bam-1791	253	11	are	be	AUX
bam-1791	253	12	down	down	ADV
bam-1791	253	13	-	-	PUNCT
bam-1791	253	14	regulated	regulated	ADJ
bam-1791	253	15	whereas	whereas	SCONJ
bam-1791	253	16	fast	fast	ADJ
bam-1791	253	17	isoforms	isoform	NOUN
bam-1791	253	18	increase	increase	VERB
bam-1791	253	19	in	in	ADP
bam-1791	253	20	relative	relative	ADJ
bam-1791	253	21	density	density	NOUN
bam-1791	253	22	in	in	ADP
bam-1791	253	23	parallel	parallel	NOUN
bam-1791	253	24	to	to	ADP
bam-1791	253	25	maturation	maturation	NOUN
bam-1791	253	26	of	of	ADP
bam-1791	253	27	e	e	NOUN
bam-1791	253	28	-	-	NOUN
bam-1791	253	29	c	c	ADJ
bam-1791	253	30	coupling	couple	VERB
bam-1791	253	31	machinery	machinery	NOUN
bam-1791	253	32	.	.	PUNCT
bam-1791	254	1	in	in	ADP
bam-1791	254	2	fact	fact	NOUN
bam-1791	254	3	calsequestrin	calsequestrin	PROPN
bam-1791	254	4	(	(	PUNCT
bam-1791	254	5	casq1	casq1	PROPN
bam-1791	254	6	)	)	PUNCT
bam-1791	254	7	,	,	PUNCT
bam-1791	254	8	the	the	DET
bam-1791	254	9	main	main	ADJ
bam-1791	254	10	ca2	ca2	NOUN
bam-1791	254	11	+	+	CCONJ
bam-1791	254	12	binding	bind	VERB
bam-1791	254	13	protein	protein	NOUN
bam-1791	254	14	of	of	ADP
bam-1791	254	15	sr	sr	PROPN
bam-1791	254	16	in	in	ADP
bam-1791	254	17	adult	adult	NOUN
bam-1791	254	18	fast	fast	ADJ
bam-1791	254	19	-	-	PUNCT
bam-1791	254	20	twitch	twitch	NOUN
bam-1791	254	21	muscles	muscle	NOUN
bam-1791	254	22	the	the	DET
bam-1791	254	23	sr	sr	PROPN
bam-1791	254	24	-	-	PUNCT
bam-1791	254	25	er	er	INTJ
bam-1791	254	26	ca2	ca2	PROPN
bam-1791	254	27	+	+	PROPN
bam-1791	254	28	atpase	atpase	PROPN
bam-1791	254	29	(	(	PUNCT
bam-1791	254	30	serca1	serca1	PROPN
bam-1791	254	31	)	)	PUNCT
bam-1791	254	32	and	and	CCONJ
bam-1791	254	33	the	the	DET
bam-1791	254	34	ca2	ca2	PROPN
bam-1791	254	35	+	+	PROPN
bam-1791	254	36	channel	channel	NOUN
bam-1791	254	37	(	(	PUNCT
bam-1791	254	38	ryr1	ryr1	NOUN
bam-1791	254	39	)	)	PUNCT
bam-1791	254	40	,	,	PUNCT
bam-1791	254	41	accumulate	accumulate	VERB
bam-1791	254	42	during	during	ADP
bam-1791	254	43	post	post	ADJ
bam-1791	254	44	-	-	ADJ
bam-1791	254	45	natal	natal	ADJ
bam-1791	254	46	development	development	NOUN
bam-1791	254	47	.	.	PUNCT
bam-1791	255	1	the	the	DET
bam-1791	255	2	aim	aim	NOUN
bam-1791	255	3	of	of	ADP
bam-1791	255	4	this	this	DET
bam-1791	255	5	study	study	NOUN
bam-1791	255	6	is	be	AUX
bam-1791	255	7	to	to	PART
bam-1791	255	8	compare	compare	VERB
bam-1791	255	9	edl	edl	PROPN
bam-1791	255	10	from	from	ADP
bam-1791	255	11	wt	wt	PRON
bam-1791	255	12	and	and	CCONJ
bam-1791	255	13	casq1	casq1	NOUN
bam-1791	255	14	-	-	PUNCT
bam-1791	255	15	null	null	ADJ
bam-1791	255	16	mice	mouse	NOUN
bam-1791	255	17	,	,	PUNCT
bam-1791	255	18	in	in	ADP
bam-1791	255	19	the	the	DET
bam-1791	255	20	first	first	ADJ
bam-1791	255	21	month	month	NOUN
bam-1791	255	22	of	of	ADP
bam-1791	255	23	development	development	NOUN
bam-1791	255	24	.	.	PUNCT
bam-1791	256	1	expression	expression	NOUN
bam-1791	256	2	of	of	ADP
bam-1791	256	3	main	main	ADJ
bam-1791	256	4	structural	structural	ADJ
bam-1791	256	5	and	and	CCONJ
bam-1791	256	6	functional	functional	ADJ
bam-1791	256	7	sr	sr	PROPN
bam-1791	256	8	proteins	protein	NOUN
bam-1791	256	9	was	be	AUX
bam-1791	256	10	studied	study	VERB
bam-1791	256	11	by	by	ADP
bam-1791	256	12	western	western	ADJ
bam-1791	256	13	blotting	blotting	NOUN
bam-1791	256	14	and	and	CCONJ
bam-1791	256	15	rt	rt	NOUN
bam-1791	256	16	-	-	PUNCT
bam-1791	256	17	pcr	pcr	NOUN
bam-1791	256	18	in	in	ADP
bam-1791	256	19	conjunction	conjunction	NOUN
bam-1791	256	20	with	with	ADP
bam-1791	256	21	ca2	ca2	PROPN
bam-1791	256	22	+	+	NOUN
bam-1791	256	23	release	release	NOUN
bam-1791	256	24	properties	property	NOUN
bam-1791	256	25	.	.	PUNCT
bam-1791	257	1	the	the	DET
bam-1791	257	2	main	main	ADJ
bam-1791	257	3	findings	finding	NOUN
bam-1791	257	4	in	in	ADP
bam-1791	257	5	1	1	NUM
bam-1791	257	6	-	-	PUNCT
bam-1791	257	7	month	month	NOUN
bam-1791	257	8	-	-	PUNCT
bam-1791	257	9	old	old	ADJ
bam-1791	257	10	casq1	casq1	NOUN
bam-1791	257	11	-	-	PUNCT
bam-1791	257	12	null	null	ADJ
bam-1791	257	13	mice	mouse	NOUN
bam-1791	257	14	were	be	AUX
bam-1791	257	15	:	:	PUNCT
bam-1791	257	16	i	i	X
bam-1791	257	17	)	)	PUNCT
bam-1791	257	18	down	down	ADP
bam-1791	257	19	-	-	PUNCT
bam-1791	257	20	regulation	regulation	NOUN
bam-1791	257	21	of	of	ADP
bam-1791	257	22	casq2	casq2	PROPN
bam-1791	257	23	,	,	PUNCT
bam-1791	257	24	sarcalumenin	sarcalumenin	ADJ
bam-1791	257	25	and	and	CCONJ
bam-1791	257	26	serca1	serca1	NOUN
bam-1791	257	27	since	since	SCONJ
bam-1791	257	28	post	post	ADJ
bam-1791	257	29	-	-	ADJ
bam-1791	257	30	natal	natal	ADJ
bam-1791	257	31	day	day	NOUN
bam-1791	257	32	16	16	NUM
bam-1791	257	33	;	;	PUNCT
bam-1791	257	34	ii	ii	X
bam-1791	257	35	)	)	PUNCT
bam-1791	257	36	normal	normal	ADJ
bam-1791	257	37	expression	expression	NOUN
bam-1791	257	38	of	of	ADP
bam-1791	257	39	dhpr	dhpr	NOUN
bam-1791	257	40	and	and	CCONJ
bam-1791	257	41	tendency	tendency	NOUN
bam-1791	257	42	of	of	ADP
bam-1791	257	43	ryr1	ryr1	NOUN
bam-1791	257	44	to	to	PART
bam-1791	257	45	accumulate	accumulate	VERB
bam-1791	257	46	despite	despite	SCONJ
bam-1791	257	47	mrna	mrna	PROPN
bam-1791	257	48	down	down	ADP
bam-1791	257	49	-	-	PUNCT
bam-1791	257	50	regulation	regulation	NOUN
bam-1791	257	51	;	;	PUNCT
bam-1791	257	52	iii	iii	X
bam-1791	257	53	)	)	PUNCT
bam-1791	257	54	activation	activation	NOUN
bam-1791	257	55	of	of	ADP
bam-1791	257	56	the	the	DET
bam-1791	257	57	unfolded	unfold	VERB
bam-1791	257	58	protein	protein	NOUN
bam-1791	257	59	response	response	NOUN
bam-1791	257	60	(	(	PUNCT
bam-1791	257	61	upr	upr	NOUN
bam-1791	257	62	)	)	PUNCT
bam-1791	257	63	via	via	ADP
bam-1791	257	64	the	the	DET
bam-1791	257	65	xbp1	xbp1	PROPN
bam-1791	257	66	pathway	pathway	NOUN
bam-1791	257	67	.	.	PUNCT
bam-1791	258	1	taken	take	VERB
bam-1791	258	2	together	together	ADV
bam-1791	258	3	these	these	DET
bam-1791	258	4	results	result	NOUN
bam-1791	258	5	suggest	suggest	VERB
bam-1791	258	6	a	a	DET
bam-1791	258	7	pivotal	pivotal	ADJ
bam-1791	258	8	role	role	NOUN
bam-1791	258	9	for	for	ADP
bam-1791	258	10	casq1	casq1	NOUN
bam-1791	258	11	in	in	ADP
bam-1791	258	12	orchestrating	orchestrate	VERB
bam-1791	258	13	sr	sr	PROPN
bam-1791	258	14	maturation	maturation	NOUN
bam-1791	258	15	of	of	ADP
bam-1791	258	16	fast	fast	ADJ
bam-1791	258	17	-	-	PUNCT
bam-1791	258	18	twitch	twitch	NOUN
bam-1791	258	19	muscles	muscle	NOUN
bam-1791	258	20	during	during	ADP
bam-1791	258	21	post	post	ADJ
bam-1791	258	22	-	-	ADJ
bam-1791	258	23	natal	natal	ADJ
bam-1791	258	24	development	development	NOUN
bam-1791	258	25	and	and	CCONJ
bam-1791	258	26	indicate	indicate	VERB
bam-1791	258	27	that	that	DET
bam-1791	258	28	regulation	regulation	NOUN
bam-1791	258	29	of	of	ADP
bam-1791	258	30	ca2	ca2	PROPN
bam-1791	258	31	+	+	NOUN
bam-1791	258	32	signals	signal	NOUN
bam-1791	258	33	might	might	AUX
bam-1791	258	34	be	be	AUX
bam-1791	258	35	the	the	DET
bam-1791	258	36	possible	possible	ADJ
bam-1791	258	37	mechanism	mechanism	NOUN
bam-1791	258	38	.	.	PUNCT
bam-1791	259	1	22	22	NUM
bam-1791	259	2	.	.	PUNCT
bam-1791	260	1	structural	structural	ADJ
bam-1791	260	2	adaptation	adaptation	NOUN
bam-1791	260	3	of	of	ADP
bam-1791	260	4	the	the	DET
bam-1791	260	5	ec	ec	PROPN
bam-1791	260	6	-	-	PUNCT
bam-1791	260	7	coupling	couple	VERB
bam-1791	260	8	apparatus	apparatus	NOUN
bam-1791	260	9	in	in	ADP
bam-1791	260	10	calsequestrin-1	calsequestrin-1	PROPN
bam-1791	260	11	knockout	knockout	NOUN
bam-1791	260	12	mice	mouse	NOUN
bam-1791	260	13	:	:	PUNCT
bam-1791	260	14	any	any	DET
bam-1791	260	15	role	role	NOUN
bam-1791	260	16	in	in	ADP
bam-1791	260	17	their	their	PRON
bam-1791	260	18	susceptibility	susceptibility	NOUN
bam-1791	260	19	to	to	ADP
bam-1791	260	20	malignant	malignant	ADJ
bam-1791	260	21	hypertermia	hypertermia	NOUN
bam-1791	260	22	(	(	PUNCT
bam-1791	260	23	mh	mh	PROPN
bam-1791	260	24	)	)	PUNCT
bam-1791	260	25	and	and	CCONJ
bam-1791	260	26	environmetal	environmetal	ADJ
bam-1791	260	27	heat	heat	NOUN
bam-1791	260	28	stroke	stroke	NOUN
bam-1791	260	29	(	(	PUNCT
bam-1791	260	30	ehs	ehs	PROPN
bam-1791	260	31	)	)	PUNCT
bam-1791	260	32	?	?	PUNCT
bam-1791	261	1	c.	c.	PROPN
bam-1791	261	2	paolini	paolini	PROPN
bam-1791	261	3	,	,	PUNCT
bam-1791	261	4	a.	a.	NOUN
bam-1791	261	5	michelucci	michelucci	NOUN
bam-1791	261	6	,	,	PUNCT
bam-1791	261	7	and	and	CCONJ
bam-1791	261	8	f.	f.	PROPN
bam-1791	261	9	protasi	protasi	PROPN
bam-1791	261	10	cesi	cesi	PROPN
bam-1791	261	11	center	center	PROPN
bam-1791	261	12	for	for	ADP
bam-1791	261	13	research	research	NOUN
bam-1791	261	14	on	on	ADP
bam-1791	261	15	ageing	ageing	NOUN
bam-1791	261	16	&	&	CCONJ
bam-1791	261	17	dni	dni	PROPN
bam-1791	261	18	dept	dept	PROPN
bam-1791	261	19	neuroscience	neuroscience	PROPN
bam-1791	261	20	and	and	CCONJ
bam-1791	261	21	imaging	imaging	NOUN
bam-1791	261	22	,	,	PUNCT
bam-1791	261	23	university	university	NOUN
bam-1791	261	24	g.	g.	PROPN
bam-1791	261	25	d'annunzio	d'annunzio	PROPN
bam-1791	261	26	of	of	ADP
bam-1791	261	27	chieti	chieti	PROPN
bam-1791	261	28	,	,	PUNCT
bam-1791	261	29	italy	italy	PROPN
bam-1791	261	30	calsequestrin	calsequestrin	PROPN
bam-1791	261	31	(	(	PUNCT
bam-1791	261	32	casq	casq	PROPN
bam-1791	261	33	)	)	PUNCT
bam-1791	261	34	is	be	AUX
bam-1791	261	35	the	the	DET
bam-1791	261	36	major	major	ADJ
bam-1791	261	37	sarcoplasmic	sarcoplasmic	NOUN
bam-1791	261	38	reticulum	reticulum	NOUN
bam-1791	261	39	(	(	PUNCT
bam-1791	261	40	sr	sr	PROPN
bam-1791	261	41	)	)	PUNCT
bam-1791	261	42	ca2	ca2	PROPN
bam-1791	261	43	+	+	CCONJ
bam-1791	261	44	binding	bind	VERB
bam-1791	261	45	protein	protein	NOUN
bam-1791	261	46	of	of	ADP
bam-1791	261	47	skeletal	skeletal	ADJ
bam-1791	261	48	fibers	fiber	NOUN
bam-1791	261	49	,	,	PUNCT
bam-1791	261	50	expressed	express	VERB
bam-1791	261	51	in	in	ADP
bam-1791	261	52	two	two	NUM
bam-1791	261	53	different	different	ADJ
bam-1791	261	54	isoforms	isoform	NOUN
bam-1791	261	55	(	(	PUNCT
bam-1791	261	56	casq	casq	NOUN
bam-1791	261	57	1	1	NUM
bam-1791	261	58	and	and	CCONJ
bam-1791	261	59	2	2	NUM
bam-1791	261	60	)	)	PUNCT
bam-1791	261	61	at	at	ADP
bam-1791	261	62	different	different	ADJ
bam-1791	261	63	developmental	developmental	ADJ
bam-1791	261	64	stages	stage	NOUN
bam-1791	261	65	.	.	PUNCT
bam-1791	262	1	ablation	ablation	NOUN
bam-1791	262	2	of	of	ADP
bam-1791	262	3	casq1	casq1	PROPN
bam-1791	262	4	in	in	ADP
bam-1791	262	5	mice	mice	NOUN
bam-1791	262	6	is	be	AUX
bam-1791	262	7	not	not	PART
bam-1791	262	8	lethal	lethal	ADJ
bam-1791	262	9	,	,	PUNCT
bam-1791	262	10	but	but	CCONJ
bam-1791	262	11	results	result	NOUN
bam-1791	262	12	in	in	ADP
bam-1791	262	13	increased	increase	VERB
bam-1791	262	14	susceptibility	susceptibility	NOUN
bam-1791	262	15	of	of	ADP
bam-1791	262	16	casq1	casq1	PROPN
bam-1791	262	17	-	-	PUNCT
bam-1791	262	18	null	null	ADJ
bam-1791	262	19	mice	mouse	NOUN
bam-1791	262	20	to	to	AUX
bam-1791	262	21	trigger	trigger	VERB
bam-1791	262	22	lethal	lethal	ADJ
bam-1791	262	23	episodes	episode	NOUN
bam-1791	262	24	when	when	SCONJ
bam-1791	262	25	exposed	expose	VERB
bam-1791	262	26	to	to	ADP
bam-1791	262	27	volatile	volatile	ADJ
bam-1791	262	28	anesthetics	anesthetic	NOUN
bam-1791	262	29	or	or	CCONJ
bam-1791	262	30	heat	heat	NOUN
bam-1791	262	31	,	,	PUNCT
bam-1791	262	32	hyper	hyper	ADJ
bam-1791	262	33	-	-	ADJ
bam-1791	262	34	metabolic	metabolic	ADJ
bam-1791	262	35	disorders	disorder	NOUN
bam-1791	262	36	known	know	VERB
bam-1791	262	37	as	as	ADP
bam-1791	262	38	malignant	malignant	ADJ
bam-1791	262	39	hyperthermia	hyperthermia	NOUN
bam-1791	262	40	(	(	PUNCT
bam-1791	262	41	mh	mh	PROPN
bam-1791	262	42	)	)	PUNCT
bam-1791	262	43	and	and	CCONJ
bam-1791	262	44	environmental	environmental	ADJ
bam-1791	262	45	heat	heat	NOUN
bam-1791	262	46	stroke	stroke	NOUN
bam-1791	262	47	(	(	PUNCT
bam-1791	262	48	ehs	ehs	PROPN
bam-1791	262	49	)	)	PUNCT
bam-1791	262	50	.	.	PUNCT
bam-1791	263	1	what	what	PRON
bam-1791	263	2	causes	cause	VERB
bam-1791	263	3	mh	mh	PROPN
bam-1791	263	4	/	/	SYM
bam-1791	263	5	ehs	ehs	PROPN
bam-1791	263	6	susceptibility	susceptibility	NOUN
bam-1791	263	7	of	of	ADP
bam-1791	263	8	casq1	casq1	PROPN
bam-1791	263	9	-	-	PUNCT
bam-1791	263	10	null	null	ADJ
bam-1791	263	11	mice	mouse	NOUN
bam-1791	263	12	is	be	AUX
bam-1791	263	13	still	still	ADV
bam-1791	263	14	under	under	ADP
bam-1791	263	15	investigation	investigation	NOUN
bam-1791	263	16	.	.	PUNCT
bam-1791	264	1	here	here	ADV
bam-1791	264	2	,	,	PUNCT
bam-1791	264	3	we	we	PRON
bam-1791	264	4	analyzed	analyze	VERB
bam-1791	264	5	the	the	DET
bam-1791	264	6	post	post	ADJ
bam-1791	264	7	-	-	ADJ
bam-1791	264	8	natal	natal	ADJ
bam-1791	264	9	maturation	maturation	NOUN
bam-1791	264	10	of	of	ADP
bam-1791	264	11	the	the	DET
bam-1791	264	12	sarcotubular	sarcotubular	ADJ
bam-1791	264	13	system	system	NOUN
bam-1791	264	14	in	in	ADP
bam-1791	264	15	casq1	casq1	PROPN
bam-1791	264	16	-	-	PUNCT
bam-1791	264	17	null	null	ADJ
bam-1791	264	18	edl	edl	PROPN
bam-1791	264	19	fibers	fiber	NOUN
bam-1791	264	20	and	and	CCONJ
bam-1791	264	21	its	its	PRON
bam-1791	264	22	possible	possible	ADJ
bam-1791	264	23	implication	implication	NOUN
bam-1791	264	24	in	in	ADP
bam-1791	264	25	the	the	DET
bam-1791	264	26	hyper	hyper	ADJ
bam-1791	264	27	-	-	ADJ
bam-1791	264	28	metabolic	metabolic	ADJ
bam-1791	264	29	syndrome	syndrome	NOUN
bam-1791	264	30	.	.	PUNCT
bam-1791	265	1	western	western	ADJ
bam-1791	265	2	-	-	PUNCT
bam-1791	265	3	blot	blot	NOUN
bam-1791	265	4	analysis	analysis	NOUN
bam-1791	265	5	indicates	indicate	VERB
bam-1791	265	6	that	that	SCONJ
bam-1791	265	7	casq2	casq2	PROPN
bam-1791	265	8	,	,	PUNCT
bam-1791	265	9	abundantly	abundantly	ADV
bam-1791	265	10	expressed	express	VERB
bam-1791	265	11	at	at	ADP
bam-1791	265	12	birth	birth	NOUN
bam-1791	265	13	,	,	PUNCT
bam-1791	265	14	is	be	AUX
bam-1791	265	15	down	down	ADV
bam-1791	265	16	-	-	PUNCT
bam-1791	265	17	regulated	regulate	VERB
bam-1791	265	18	post	post	NOUN
bam-1791	265	19	-	-	ADJ
bam-1791	265	20	natally	natally	ADV
bam-1791	265	21	,	,	PUNCT
bam-1791	265	22	just	just	ADV
bam-1791	265	23	as	as	ADP
bam-1791	265	24	in	in	ADP
bam-1791	265	25	wild	wild	ADJ
bam-1791	265	26	type	type	NOUN
bam-1791	265	27	(	(	PUNCT
bam-1791	265	28	wt	wt	NOUN
bam-1791	265	29	)	)	PUNCT
bam-1791	265	30	edl	edl	PROPN
bam-1791	265	31	,	,	PUNCT
bam-1791	265	32	leaving	leave	VERB
bam-1791	265	33	the	the	DET
bam-1791	265	34	majority	majority	NOUN
bam-1791	265	35	of	of	ADP
bam-1791	265	36	knockout	knockout	NOUN
bam-1791	265	37	fibers	fiber	NOUN
bam-1791	265	38	without	without	ADP
bam-1791	265	39	any	any	DET
bam-1791	265	40	casq	casq	NOUN
bam-1791	265	41	.	.	PUNCT
bam-1791	266	1	structural	structural	ADJ
bam-1791	266	2	post	post	ADJ
bam-1791	266	3	-	-	ADJ
bam-1791	266	4	natal	natal	ADJ
bam-1791	266	5	maturation	maturation	NOUN
bam-1791	266	6	of	of	ADP
bam-1791	266	7	the	the	DET
bam-1791	266	8	ec	ec	PROPN
bam-1791	266	9	coupling	couple	VERB
bam-1791	266	10	units	unit	NOUN
bam-1791	266	11	in	in	ADP
bam-1791	266	12	knockout	knockout	NOUN
bam-1791	266	13	fibers	fiber	NOUN
bam-1791	266	14	is	be	AUX
bam-1791	266	15	characterized	characterize	VERB
bam-1791	266	16	by	by	ADP
bam-1791	266	17	a	a	PRON
bam-1791	266	18	)	)	PUNCT
bam-1791	266	19	an	an	DET
bam-1791	266	20	incomplete	incomplete	ADJ
bam-1791	266	21	reorganization	reorganization	NOUN
bam-1791	266	22	of	of	ADP
bam-1791	266	23	the	the	DET
bam-1791	266	24	ttubule	ttubule	NOUN
bam-1791	266	25	from	from	ADP
bam-1791	266	26	longitudinal	longitudinal	ADJ
bam-1791	266	27	to	to	ADP
bam-1791	266	28	transversally	transversally	ADV
bam-1791	266	29	oriented	orient	VERB
bam-1791	266	30	,	,	PUNCT
bam-1791	266	31	as	as	SCONJ
bam-1791	266	32	it	it	PRON
bam-1791	266	33	would	would	AUX
bam-1791	266	34	normally	normally	ADV
bam-1791	266	35	occur	occur	VERB
bam-1791	266	36	in	in	ADP
bam-1791	266	37	wt	wt	NOUN
bam-1791	266	38	muscle	muscle	NOUN
bam-1791	266	39	,	,	PUNCT
bam-1791	266	40	and	and	CCONJ
bam-1791	266	41	b)formation	b)formation	NOUN
bam-1791	266	42	of	of	ADP
bam-1791	266	43	multilayered	multilayered	ADJ
bam-1791	266	44	junctions	junction	NOUN
bam-1791	266	45	,	,	PUNCT
bam-1791	266	46	characteristic	characteristic	ADJ
bam-1791	266	47	of	of	ADP
bam-1791	266	48	adult	adult	NOUN
bam-1791	266	49	casq1	casq1	PROPN
bam-1791	266	50	-	-	PUNCT
bam-1791	266	51	null	null	ADJ
bam-1791	266	52	edl	edl	PROPN
bam-1791	266	53	fibers	fiber	NOUN
bam-1791	266	54	,	,	PUNCT
bam-1791	266	55	a	a	DET
bam-1791	266	56	change	change	NOUN
bam-1791	266	57	that	that	PRON
bam-1791	266	58	starts	start	VERB
bam-1791	266	59	after	after	ADP
bam-1791	266	60	1	1	NUM
bam-1791	266	61	month	month	NOUN
bam-1791	266	62	of	of	ADP
bam-1791	266	63	age	age	NOUN
bam-1791	266	64	.	.	PUNCT
bam-1791	267	1	interestingly	interestingly	ADV
bam-1791	267	2	,	,	PUNCT
bam-1791	267	3	mice	mouse	NOUN
bam-1791	267	4	at	at	ADP
bam-1791	267	5	early	early	ADJ
bam-1791	267	6	stages	stage	NOUN
bam-1791	267	7	of	of	ADP
bam-1791	267	8	development	development	NOUN
bam-1791	267	9	(	(	PUNCT
bam-1791	267	10	around	around	ADV
bam-1791	267	11	1	1	NUM
bam-1791	267	12	month	month	NOUN
bam-1791	267	13	of	of	ADP
bam-1791	267	14	age	age	NOUN
bam-1791	267	15	)	)	PUNCT
bam-1791	267	16	,	,	PUNCT
bam-1791	267	17	when	when	SCONJ
bam-1791	267	18	the	the	DET
bam-1791	267	19	number	number	NOUN
bam-1791	267	20	of	of	ADP
bam-1791	267	21	multi	multi	ADJ
bam-1791	267	22	-	-	ADJ
bam-1791	267	23	layered	layered	ADJ
bam-1791	267	24	junctions	junction	NOUN
bam-1791	267	25	is	be	AUX
bam-1791	267	26	limited	limit	VERB
bam-1791	267	27	,	,	PUNCT
bam-1791	267	28	show	show	VERB
bam-1791	267	29	lower	low	ADJ
bam-1791	267	30	susceptibility	susceptibility	NOUN
bam-1791	267	31	to	to	PART
bam-1791	267	32	heat	heat	VERB
bam-1791	267	33	stress	stress	NOUN
bam-1791	267	34	than	than	ADP
bam-1791	267	35	adults	adult	NOUN
bam-1791	267	36	(	(	PUNCT
bam-1791	267	37	~20	~20	ADP
bam-1791	267	38	%	%	NOUN
bam-1791	267	39	vs.	vs.	ADP
bam-1791	267	40	~80	~80	NOUN
bam-1791	267	41	%	%	NOUN
bam-1791	267	42	of	of	ADP
bam-1791	267	43	lethality	lethality	NOUN
bam-1791	267	44	)	)	PUNCT
bam-1791	267	45	and	and	CCONJ
bam-1791	267	46	a	a	DET
bam-1791	267	47	lower	low	ADJ
bam-1791	267	48	internal	internal	ADJ
bam-1791	267	49	temperature	temperature	NOUN
bam-1791	267	50	(	(	PUNCT
bam-1791	267	51	reduced	reduce	VERB
bam-1791	267	52	hyperthermia	hyperthermia	NOUN
bam-1791	267	53	)	)	PUNCT
bam-1791	267	54	.	.	PUNCT
bam-1791	268	1	these	these	DET
bam-1791	268	2	findings	finding	NOUN
bam-1791	268	3	suggest	suggest	VERB
bam-1791	268	4	that	that	SCONJ
bam-1791	268	5	the	the	DET
bam-1791	268	6	structural	structural	ADJ
bam-1791	268	7	modifications	modification	NOUN
bam-1791	268	8	of	of	ADP
bam-1791	268	9	the	the	DET
bam-1791	268	10	ec	ec	PROPN
bam-1791	268	11	coupling	couple	VERB
bam-1791	268	12	apparatus	apparatus	NOUN
bam-1791	268	13	occurring	occur	VERB
bam-1791	268	14	during	during	ADP
bam-1791	268	15	post	post	ADJ
bam-1791	268	16	-	-	ADJ
bam-1791	268	17	natal	natal	ADJ
bam-1791	268	18	maturation	maturation	NOUN
bam-1791	268	19	may	may	AUX
bam-1791	268	20	play	play	VERB
bam-1791	268	21	a	a	DET
bam-1791	268	22	role	role	NOUN
bam-1791	268	23	in	in	ADP
bam-1791	268	24	the	the	DET
bam-1791	268	25	mh	mh	PROPN
bam-1791	268	26	/	/	SYM
bam-1791	268	27	ehs	ehs	PROPN
bam-1791	268	28	susceptibility	susceptibility	NOUN
bam-1791	268	29	of	of	ADP
bam-1791	268	30	casq1	casq1	PROPN
bam-1791	268	31	-	-	PUNCT
bam-1791	268	32	null	null	ADJ
bam-1791	268	33	male	male	ADJ
bam-1791	268	34	mice	mouse	NOUN
bam-1791	268	35	.	.	PUNCT
bam-1791	269	1	23	23	NUM
bam-1791	269	2	.	.	X
bam-1791	269	3	oxidative	oxidative	ADJ
bam-1791	269	4	stress	stress	NOUN
bam-1791	269	5	underlies	underlie	VERB
bam-1791	269	6	sudden	sudden	ADJ
bam-1791	269	7	death	death	NOUN
bam-1791	269	8	in	in	ADP
bam-1791	269	9	calsequestrin-1	calsequestrin-1	PROPN
bam-1791	269	10	knockout	knockout	NOUN
bam-1791	269	11	(	(	PUNCT
bam-1791	269	12	casq1null	casq1null	NOUN
bam-1791	269	13	)	)	PUNCT
bam-1791	269	14	mice	mouse	NOUN
bam-1791	269	15	suffering	suffering	NOUN
bam-1791	269	16	of	of	ADP
bam-1791	269	17	malignant	malignant	ADJ
bam-1791	269	18	hyperthermia	hyperthermia	NOUN
bam-1791	269	19	(	(	PUNCT
bam-1791	269	20	mh	mh	PROPN
bam-1791	269	21	)	)	PUNCT
bam-1791	269	22	and	and	CCONJ
bam-1791	269	23	environmental	environmental	ADJ
bam-1791	269	24	heat	heat	NOUN
bam-1791	269	25	stroke	stroke	NOUN
bam-1791	269	26	(	(	PUNCT
bam-1791	269	27	ehs	ehs	PROPN
bam-1791	269	28	)	)	PUNCT
bam-1791	269	29	michelucci	michelucci	VERB
bam-1791	269	30	a	a	DET
bam-1791	269	31	1	1	NUM
bam-1791	269	32	,	,	PUNCT
bam-1791	269	33	paolini	paolini	PROPN
bam-1791	269	34	c	c	PROPN
bam-1791	269	35	1	1	NUM
bam-1791	269	36	,	,	PUNCT
bam-1791	269	37	pietrangelo	pietrangelo	PROPN
bam-1791	269	38	l	l	PROPN
bam-1791	269	39	1	1	NUM
bam-1791	269	40	,	,	PUNCT
bam-1791	269	41	canato	canato	NOUN
bam-1791	269	42	m	m	PROPN
bam-1791	269	43	2	2	NUM
bam-1791	269	44	,	,	PUNCT
bam-1791	269	45	wei	wei	X
bam-1791	269	46	3	3	NUM
bam-1791	269	47	l	l	NOUN
bam-1791	269	48	,	,	PUNCT
bam-1791	269	49	dirksen	dirksen	PROPN
bam-1791	269	50	rt	rt	PROPN
bam-1791	269	51	3	3	NUM
bam-1791	269	52	,	,	PUNCT
bam-1791	269	53	reggiani	reggiani	NOUN
bam-1791	269	54	c	c	NOUN
bam-1791	269	55	2	2	NUM
bam-1791	269	56	,	,	PUNCT
bam-1791	269	57	protasi	protasi	NOUN
bam-1791	269	58	f	f	PROPN
bam-1791	269	59	1	1	NUM
bam-1791	269	60	1cesi	1cesi	NUM
bam-1791	269	61	center	center	NOUN
bam-1791	269	62	for	for	ADP
bam-1791	269	63	research	research	NOUN
bam-1791	269	64	on	on	ADP
bam-1791	269	65	ageing	ageing	NOUN
bam-1791	269	66	&	&	CCONJ
bam-1791	269	67	dni	dni	PROPN
bam-1791	269	68	dept	dept	PROPN
bam-1791	269	69	neuroscience	neuroscience	PROPN
bam-1791	269	70	and	and	CCONJ
bam-1791	269	71	imaging	imaging	NOUN
bam-1791	269	72	,	,	PUNCT
bam-1791	269	73	univ	univ	PROPN
bam-1791	269	74	.	.	PUNCT
bam-1791	270	1	g.	g.	PROPN
bam-1791	270	2	d'annunzio	d'annunzio	PROPN
bam-1791	270	3	,	,	PUNCT
bam-1791	270	4	chieti	chieti	PROPN
bam-1791	270	5	,	,	PUNCT
bam-1791	270	6	italy	italy	PROPN
bam-1791	270	7	2dept	2dept	NUM
bam-1791	270	8	human	human	ADJ
bam-1791	270	9	anatomy	anatomy	NOUN
bam-1791	270	10	and	and	CCONJ
bam-1791	270	11	physiology	physiology	NOUN
bam-1791	270	12	,	,	PUNCT
bam-1791	270	13	univ	univ	PROPN
bam-1791	270	14	.	.	PROPN
bam-1791	270	15	of	of	ADP
bam-1791	270	16	padova	padova	PROPN
bam-1791	270	17	,	,	PUNCT
bam-1791	270	18	italy	italy	PROPN
bam-1791	270	19	3dept	3dept	NUM
bam-1791	270	20	pharmacology	pharmacology	NOUN
bam-1791	270	21	and	and	CCONJ
bam-1791	270	22	physiology	physiology	NOUN
bam-1791	270	23	,	,	PUNCT
bam-1791	270	24	univ	univ	PROPN
bam-1791	270	25	.	.	PROPN
bam-1791	270	26	of	of	ADP
bam-1791	270	27	rochester	rochester	PROPN
bam-1791	270	28	medical	medical	ADJ
bam-1791	270	29	center	center	NOUN
bam-1791	270	30	,	,	PUNCT
bam-1791	270	31	ny	ny	PROPN
bam-1791	270	32	ix	ix	PROPN
bam-1791	270	33	iim	iim	PROPN
bam-1791	270	34	meeting	meeting	NOUN
bam-1791	270	35	,	,	PUNCT
bam-1791	270	36	acaya	acaya	NOUN
bam-1791	270	37	(	(	PUNCT
bam-1791	270	38	lecce	lecce	PROPN
bam-1791	270	39	)	)	PUNCT
bam-1791	270	40	,	,	PUNCT
bam-1791	270	41	october	october	PROPN
bam-1791	270	42	12	12	NUM
bam-1791	270	43	-	-	SYM
bam-1791	270	44	14	14	NUM
bam-1791	270	45	,	,	PUNCT
bam-1791	270	46	2012	2012	NUM
bam-1791	270	47	european	european	PROPN
bam-1791	270	48	journal	journal	PROPN
bam-1791	270	49	translational	translational	ADJ
bam-1791	270	50	myology	myology	NOUN
bam-1791	270	51	basic	basic	ADJ
bam-1791	270	52	applied	apply	VERB
bam-1791	270	53	myology	myology	NOUN
bam-1791	270	54	2012	2012	NUM
bam-1791	270	55	;	;	PUNCT
bam-1791	270	56	22(1&2	22(1&2	NUM
bam-1791	270	57	):	):	PUNCT
bam-1791	270	58	xxx	xxx	NOUN
bam-1791	270	59	-	-	PUNCT
bam-1791	270	60	xxx	xxx	NOUN
bam-1791	270	61	30	30	NUM
bam-1791	270	62	mice	mouse	NOUN
bam-1791	270	63	lacking	lack	VERB
bam-1791	270	64	casq1	casq1	NOUN
bam-1791	270	65	a	a	DET
bam-1791	270	66	protein	protein	NOUN
bam-1791	270	67	that	that	PRON
bam-1791	270	68	modulates	modulate	VERB
bam-1791	270	69	ca2	ca2	PROPN
bam-1791	270	70	+	+	ADJ
bam-1791	270	71	-release	-release	ADJ
bam-1791	270	72	channels	channel	NOUN
bam-1791	270	73	or	or	CCONJ
bam-1791	270	74	ryanodine	ryanodine	VERB
bam-1791	270	75	receptors	receptor	NOUN
bam-1791	270	76	1	1	NUM
bam-1791	270	77	(	(	PUNCT
bam-1791	270	78	ryr1	ryr1	NOUN
bam-1791	270	79	)	)	PUNCT
bam-1791	270	80	suffers	suffer	NOUN
bam-1791	270	81	of	of	ADP
bam-1791	270	82	mh	mh	PROPN
bam-1791	270	83	and	and	CCONJ
bam-1791	270	84	ehs	ehs	PROPN
bam-1791	270	85	,	,	PUNCT
bam-1791	270	86	life	life	NOUN
bam-1791	270	87	-	-	PUNCT
bam-1791	270	88	threatening	threaten	VERB
bam-1791	270	89	disorders	disorder	NOUN
bam-1791	270	90	triggered	trigger	VERB
bam-1791	270	91	respectively	respectively	ADV
bam-1791	270	92	by	by	ADP
bam-1791	270	93	volatile	volatile	ADJ
bam-1791	270	94	anaesthetics	anaesthetic	NOUN
bam-1791	270	95	and	and	CCONJ
bam-1791	270	96	high	high	ADJ
bam-1791	270	97	temperature	temperature	NOUN
bam-1791	270	98	.	.	PUNCT
bam-1791	271	1	it	it	PRON
bam-1791	271	2	has	have	AUX
bam-1791	271	3	been	be	AUX
bam-1791	271	4	proposed	propose	VERB
bam-1791	271	5	that	that	SCONJ
bam-1791	271	6	,	,	PUNCT
bam-1791	271	7	during	during	ADP
bam-1791	271	8	mh	mh	PROPN
bam-1791	271	9	/	/	SYM
bam-1791	271	10	ehs	ehs	PROPN
bam-1791	271	11	crisis	crisis	NOUN
bam-1791	271	12	,	,	PUNCT
bam-1791	271	13	excessive	excessive	ADJ
bam-1791	271	14	oxidative	oxidative	ADJ
bam-1791	271	15	stress	stress	NOUN
bam-1791	271	16	leads	lead	VERB
bam-1791	271	17	to	to	ADP
bam-1791	271	18	increases	increase	NOUN
bam-1791	271	19	ryr1	ryr1	NOUN
bam-1791	271	20	ca2	ca2	PROPN
bam-1791	271	21	+	+	PROPN
bam-1791	271	22	leak	leak	NOUN
bam-1791	271	23	,	,	PUNCT
bam-1791	271	24	overcontracture	overcontracture	NOUN
bam-1791	271	25	and	and	CCONJ
bam-1791	271	26	rhabdomyolysis	rhabdomyolysis	NOUN
bam-1791	271	27	of	of	ADP
bam-1791	271	28	skeletal	skeletal	ADJ
bam-1791	271	29	fibers	fiber	NOUN
bam-1791	271	30	.	.	PUNCT
bam-1791	272	1	we	we	PRON
bam-1791	272	2	treated	treat	VERB
bam-1791	272	3	casq1	casq1	PROPN
bam-1791	272	4	-	-	PUNCT
bam-1791	272	5	null	null	ADJ
bam-1791	272	6	mice	mouse	NOUN
bam-1791	272	7	for	for	ADP
bam-1791	272	8	2	2	NUM
bam-1791	272	9	months	month	NOUN
bam-1791	272	10	with	with	ADP
bam-1791	272	11	n	n	X
bam-1791	272	12	-	-	PUNCT
bam-1791	272	13	acetylcysteine	acetylcysteine	NOUN
bam-1791	272	14	(	(	PUNCT
bam-1791	272	15	nac	nac	PROPN
bam-1791	272	16	,	,	PUNCT
bam-1791	272	17	a	a	DET
bam-1791	272	18	potent	potent	ADJ
bam-1791	272	19	anti	anti	ADJ
bam-1791	272	20	-	-	ADJ
bam-1791	272	21	oxidant	oxidant	ADJ
bam-1791	272	22	)	)	PUNCT
bam-1791	272	23	administered	administer	VERB
bam-1791	272	24	in	in	ADP
bam-1791	272	25	drinking	drinking	NOUN
bam-1791	272	26	water	water	NOUN
bam-1791	272	27	(	(	PUNCT
bam-1791	272	28	1	1	NUM
bam-1791	272	29	%	%	NOUN
bam-1791	272	30	w	w	NOUN
bam-1791	272	31	/	/	SYM
bam-1791	272	32	v	v	NOUN
bam-1791	272	33	)	)	PUNCT
bam-1791	272	34	.	.	PUNCT
bam-1791	273	1	nac	nac	PROPN
bam-1791	273	2	treatment	treatment	PROPN
bam-1791	273	3	resulted	result	VERB
bam-1791	273	4	in	in	ADP
bam-1791	273	5	significant	significant	ADJ
bam-1791	273	6	protection	protection	NOUN
bam-1791	273	7	of	of	ADP
bam-1791	273	8	casq1	casq1	PROPN
bam-1791	273	9	-	-	PUNCT
bam-1791	273	10	null	null	ADJ
bam-1791	273	11	mice	mouse	NOUN
bam-1791	273	12	from	from	ADP
bam-1791	273	13	lethal	lethal	ADJ
bam-1791	273	14	episodes	episode	NOUN
bam-1791	273	15	induced	induce	VERB
bam-1791	273	16	by	by	ADP
bam-1791	273	17	halothane	halothane	NOUN
bam-1791	273	18	(	(	PUNCT
bam-1791	273	19	2	2	NUM
bam-1791	273	20	%	%	NOUN
bam-1791	273	21	,	,	PUNCT
bam-1791	273	22	1h	1h	NUM
bam-1791	273	23	at	at	ADP
bam-1791	273	24	32	32	NUM
bam-1791	273	25	°	°	NOUN
bam-1791	273	26	c	c	NOUN
bam-1791	273	27	)	)	PUNCT
bam-1791	273	28	and	and	CCONJ
bam-1791	273	29	heat	heat	NOUN
bam-1791	273	30	(	(	PUNCT
bam-1791	273	31	41	41	NUM
bam-1791	273	32	°	°	NOUN
bam-1791	273	33	c	c	NOUN
bam-1791	273	34	,	,	PUNCT
bam-1791	273	35	1h	1h	NUM
bam-1791	273	36	):	):	PUNCT
bam-1791	273	37	respectively	respectively	ADV
bam-1791	273	38	,	,	PUNCT
bam-1791	273	39	the	the	DET
bam-1791	273	40	rate	rate	NOUN
bam-1791	273	41	of	of	ADP
bam-1791	273	42	mortality	mortality	NOUN
bam-1791	273	43	was	be	AUX
bam-1791	273	44	78.6	78.6	NUM
bam-1791	273	45	vs	vs	ADP
bam-1791	273	46	25.0	25.0	NUM
bam-1791	273	47	%	%	NOUN
bam-1791	273	48	and	and	CCONJ
bam-1791	273	49	85.7	85.7	NUM
bam-1791	273	50	vs	vs	ADP
bam-1791	273	51	30.0	30.0	NUM
bam-1791	273	52	%	%	NOUN
bam-1791	273	53	in	in	ADP
bam-1791	273	54	controls	control	NOUN
bam-1791	273	55	vs	vs	ADP
bam-1791	273	56	nac	nac	NOUN
bam-1791	273	57	-	-	PUNCT
bam-1791	273	58	treated	treat	VERB
bam-1791	273	59	animals	animal	NOUN
bam-1791	273	60	.	.	PUNCT
bam-1791	274	1	this	this	DET
bam-1791	274	2	protection	protection	NOUN
bam-1791	274	3	is	be	AUX
bam-1791	274	4	likely	likely	ADJ
bam-1791	274	5	the	the	DET
bam-1791	274	6	results	result	NOUN
bam-1791	274	7	of	of	ADP
bam-1791	274	8	several	several	ADJ
bam-1791	274	9	factors	factor	NOUN
bam-1791	274	10	:	:	PUNCT
bam-1791	274	11	a	a	X
bam-1791	274	12	)	)	PUNCT
bam-1791	274	13	reduction	reduction	NOUN
bam-1791	274	14	of	of	ADP
bam-1791	274	15	oxidative	oxidative	ADJ
bam-1791	274	16	stress	stress	NOUN
bam-1791	274	17	,	,	PUNCT
bam-1791	274	18	as	as	SCONJ
bam-1791	274	19	shown	show	VERB
bam-1791	274	20	by	by	ADP
bam-1791	274	21	a	a	DET
bam-1791	274	22	decrease	decrease	NOUN
bam-1791	274	23	of	of	ADP
bam-1791	274	24	mitochondrial	mitochondrial	ADJ
bam-1791	274	25	superoxide	superoxide	NOUN
bam-1791	274	26	flashes	flash	NOUN
bam-1791	274	27	(	(	PUNCT
bam-1791	274	28	msof	msof	NOUN
bam-1791	274	29	)	)	PUNCT
bam-1791	274	30	frequency	frequency	NOUN
bam-1791	274	31	(	(	PUNCT
bam-1791	274	32	p<0.05	p<0.05	PROPN
bam-1791	274	33	)	)	PUNCT
bam-1791	274	34	;	;	PUNCT
bam-1791	274	35	b	b	X
bam-1791	274	36	)	)	PUNCT
bam-1791	274	37	decreased	decrease	VERB
bam-1791	274	38	internal	internal	ADJ
bam-1791	274	39	temperature	temperature	NOUN
bam-1791	274	40	during	during	ADP
bam-1791	274	41	heat	heat	NOUN
bam-1791	274	42	-	-	PUNCT
bam-1791	274	43	stress	stress	NOUN
bam-1791	274	44	protocol	protocol	NOUN
bam-1791	274	45	(	(	PUNCT
bam-1791	274	46	from	from	ADP
bam-1791	274	47	42.1	42.1	NUM
bam-1791	274	48	to	to	PART
bam-1791	274	49	40.8	40.8	NUM
bam-1791	274	50	°	°	NOUN
bam-1791	274	51	c	c	NOUN
bam-1791	274	52	)	)	PUNCT
bam-1791	274	53	;	;	PUNCT
bam-1791	274	54	and	and	CCONJ
bam-1791	274	55	c	c	X
bam-1791	274	56	)	)	PUNCT
bam-1791	274	57	lower	low	ADJ
bam-1791	274	58	number	number	NOUN
bam-1791	274	59	of	of	ADP
bam-1791	274	60	fibers	fiber	NOUN
bam-1791	274	61	undergoing	undergo	VERB
bam-1791	274	62	rhabdomyolysis	rhabdomyolysis	NOUN
bam-1791	274	63	(	(	PUNCT
bam-1791	274	64	from	from	ADP
bam-1791	274	65	37.6	37.6	NUM
bam-1791	274	66	to	to	PART
bam-1791	274	67	11.6	11.6	NUM
bam-1791	274	68	%	%	NOUN
bam-1791	274	69	)	)	PUNCT
bam-1791	274	70	.	.	PUNCT
bam-1791	275	1	furthermore	furthermore	ADV
bam-1791	275	2	,	,	PUNCT
bam-1791	275	3	nac	nac	PROPN
bam-1791	275	4	treatment	treatment	NOUN
bam-1791	275	5	results	result	NOUN
bam-1791	275	6	also	also	ADV
bam-1791	275	7	in	in	ADP
bam-1791	275	8	a	a	DET
bam-1791	275	9	significant	significant	ADJ
bam-1791	275	10	increase	increase	NOUN
bam-1791	275	11	of	of	ADP
bam-1791	275	12	the	the	DET
bam-1791	275	13	threshold	threshold	NOUN
bam-1791	275	14	for	for	ADP
bam-1791	275	15	caffeine	caffeine	NOUN
bam-1791	275	16	-	-	PUNCT
bam-1791	275	17	induced	induce	VERB
bam-1791	275	18	contracture	contracture	NOUN
bam-1791	275	19	(	(	PUNCT
bam-1791	275	20	in	in	ADP
bam-1791	275	21	-	-	PUNCT
bam-1791	275	22	vitro	vitro	X
bam-1791	275	23	contracture	contracture	NOUN
bam-1791	275	24	test	test	NOUN
bam-1791	275	25	)	)	PUNCT
bam-1791	275	26	.	.	PUNCT
bam-1791	276	1	these	these	DET
bam-1791	276	2	results	result	NOUN
bam-1791	276	3	suggest	suggest	VERB
bam-1791	276	4	that	that	SCONJ
bam-1791	276	5	a	a	X
bam-1791	276	6	)	)	PUNCT
bam-1791	276	7	increased	increase	VERB
bam-1791	276	8	oxidative	oxidative	ADJ
bam-1791	276	9	stress	stress	NOUN
bam-1791	276	10	may	may	AUX
bam-1791	276	11	exacerbates	exacerbate	VERB
bam-1791	276	12	the	the	DET
bam-1791	276	13	ryr1	ryr1	NOUN
bam-1791	276	14	instability	instability	NOUN
bam-1791	276	15	that	that	PRON
bam-1791	276	16	underlies	underlie	VERB
bam-1791	276	17	mh	mh	PROPN
bam-1791	276	18	/	/	SYM
bam-1791	276	19	ehs	ehs	PROPN
bam-1791	276	20	episodes	episode	NOUN
bam-1791	276	21	and	and	CCONJ
bam-1791	276	22	b	b	X
bam-1791	276	23	)	)	PUNCT
bam-1791	276	24	anti	anti	NOUN
bam-1791	276	25	-	-	ADJ
bam-1791	276	26	oxidants	oxidant	NOUN
bam-1791	276	27	drugs	drug	NOUN
bam-1791	276	28	should	should	AUX
bam-1791	276	29	be	be	AUX
bam-1791	276	30	considered	consider	VERB
bam-1791	276	31	for	for	ADP
bam-1791	276	32	the	the	DET
bam-1791	276	33	prevention	prevention	NOUN
bam-1791	276	34	/	/	SYM
bam-1791	276	35	prevention	prevention	NOUN
bam-1791	276	36	of	of	ADP
bam-1791	276	37	mh	mh	PROPN
bam-1791	276	38	and	and	CCONJ
bam-1791	276	39	over	over	ADP
bam-1791	276	40	-	-	PUNCT
bam-1791	276	41	heating	heating	NOUN
bam-1791	276	42	skeletal	skeletal	ADJ
bam-1791	276	43	muscle	muscle	NOUN
bam-1791	276	44	disorders	disorder	NOUN
bam-1791	276	45	.	.	PUNCT
bam-1791	277	1	session	session	NOUN
bam-1791	277	2	5	5	NUM
bam-1791	277	3	myopathies	myopathy	NOUN
bam-1791	277	4	and	and	CCONJ
bam-1791	277	5	neuromuscular	neuromuscular	ADJ
bam-1791	277	6	diseases	disease	NOUN
bam-1791	277	7	24	24	NUM
bam-1791	277	8	.	.	PUNCT
bam-1791	278	1	cattle	cattle	NOUN
bam-1791	278	2	congenital	congenital	ADJ
bam-1791	278	3	pseudomyotonia	pseudomyotonia	NOUN
bam-1791	278	4	:	:	PUNCT
bam-1791	278	5	an	an	DET
bam-1791	278	6	animal	animal	NOUN
bam-1791	278	7	model	model	NOUN
bam-1791	278	8	for	for	ADP
bam-1791	278	9	investigating	investigate	VERB
bam-1791	278	10	human	human	ADJ
bam-1791	278	11	brody	brody	PROPN
bam-1791	278	12	disease	disease	PROPN
bam-1791	278	13	roberta	roberta	PROPN
bam-1791	278	14	sacchetto1	sacchetto1	PROPN
bam-1791	278	15	,	,	PUNCT
bam-1791	278	16	tiziano	tiziano	PROPN
bam-1791	278	17	dorotea1	dorotea1	PROPN
bam-1791	278	18	,	,	PUNCT
bam-1791	278	19	leonardo	leonardo	PROPN
bam-1791	278	20	murgiano2	murgiano2	PROPN
bam-1791	278	21	,	,	PUNCT
bam-1791	278	22	stefania	stefania	PROPN
bam-1791	278	23	testoni3	testoni3	PROPN
bam-1791	278	24	,	,	PUNCT
bam-1791	278	25	arcangelo	arcangelo	PROPN
bam-1791	278	26	gentile4	gentile4	PROPN
bam-1791	278	27	,	,	PUNCT
bam-1791	278	28	giuseppe	giuseppe	PROPN
bam-1791	278	29	zanotti5	zanotti5	PROPN
bam-1791	278	30	,	,	PUNCT
bam-1791	278	31	cord	cord	NOUN
bam-1791	278	32	drögemüller2	drögemüller2	PROPN
bam-1791	278	33	,	,	PUNCT
bam-1791	278	34	francesco	francesco	NOUN
bam-1791	278	35	mascarello1	mascarello1	PROPN
bam-1791	278	36	1departments	1departments	NUM
bam-1791	278	37	of	of	ADP
bam-1791	278	38	biomedicina	biomedicina	PROPN
bam-1791	278	39	comparata	comparata	PROPN
bam-1791	278	40	ed	ed	PROPN
bam-1791	278	41	alimentazione	alimentazione	PROPN
bam-1791	278	42	,	,	PUNCT
bam-1791	278	43	3medicina	3medicina	NUM
bam-1791	278	44	animale	animale	ADJ
bam-1791	278	45	,	,	PUNCT
bam-1791	278	46	produzioni	produzioni	ADJ
bam-1791	278	47	e	e	NOUN
bam-1791	278	48	salute	salute	NOUN
bam-1791	278	49	,	,	PUNCT
bam-1791	278	50	5scienze	5scienze	NUM
bam-1791	278	51	biomediche	biomediche	NOUN
bam-1791	278	52	,	,	PUNCT
bam-1791	278	53	university	university	PROPN
bam-1791	278	54	of	of	ADP
bam-1791	278	55	padova	padova	PROPN
bam-1791	278	56	;	;	PUNCT
bam-1791	278	57	4department	4department	NUM
bam-1791	278	58	of	of	ADP
bam-1791	278	59	scienze	scienze	PROPN
bam-1791	278	60	mediche	mediche	PROPN
bam-1791	278	61	veterinarie	veterinarie	PROPN
bam-1791	278	62	,	,	PUNCT
bam-1791	278	63	university	university	NOUN
bam-1791	278	64	of	of	ADP
bam-1791	278	65	bologna	bologna	NOUN
bam-1791	278	66	,	,	PUNCT
bam-1791	278	67	2institute	2institute	NUM
bam-1791	278	68	of	of	ADP
bam-1791	278	69	genetics	genetic	NOUN
bam-1791	278	70	,	,	PUNCT
bam-1791	278	71	university	university	NOUN
bam-1791	278	72	of	of	ADP
bam-1791	278	73	bern	bern	PROPN
bam-1791	278	74	.	.	PUNCT
bam-1791	279	1	an	an	DET
bam-1791	279	2	inherited	inherit	VERB
bam-1791	279	3	muscle	muscle	NOUN
bam-1791	279	4	disorder	disorder	NOUN
bam-1791	279	5	defined	define	VERB
bam-1791	279	6	as	as	ADP
bam-1791	279	7	“	"	PUNCT
bam-1791	279	8	congenital	congenital	ADJ
bam-1791	279	9	pseudomyotonia	pseudomyotonia	NOUN
bam-1791	279	10	”	"	PUNCT
bam-1791	279	11	has	have	AUX
bam-1791	279	12	been	be	AUX
bam-1791	279	13	described	describe	VERB
bam-1791	279	14	in	in	ADP
bam-1791	279	15	two	two	NUM
bam-1791	279	16	important	important	ADJ
bam-1791	279	17	italian	italian	ADJ
bam-1791	279	18	cattle	cattle	NOUN
bam-1791	279	19	breeds	breed	NOUN
bam-1791	279	20	and	and	CCONJ
bam-1791	279	21	,	,	PUNCT
bam-1791	279	22	as	as	ADP
bam-1791	279	23	a	a	DET
bam-1791	279	24	single	single	ADJ
bam-1791	279	25	case	case	NOUN
bam-1791	279	26	,	,	PUNCT
bam-1791	279	27	in	in	ADP
bam-1791	279	28	a	a	DET
bam-1791	279	29	cross	cross	ADJ
bam-1791	279	30	-	-	ADJ
bam-1791	279	31	breed	breed	ADJ
bam-1791	279	32	calf	calf	NOUN
bam-1791	279	33	in	in	ADP
bam-1791	279	34	the	the	DET
bam-1791	279	35	netherlands	netherlands	PROPN
bam-1791	279	36	.	.	PUNCT
bam-1791	280	1	clinically	clinically	ADV
bam-1791	280	2	the	the	DET
bam-1791	280	3	disorder	disorder	NOUN
bam-1791	280	4	is	be	AUX
bam-1791	280	5	characterized	characterize	VERB
bam-1791	280	6	by	by	ADP
bam-1791	280	7	an	an	DET
bam-1791	280	8	exercise	exercise	NOUN
bam-1791	280	9	-	-	PUNCT
bam-1791	280	10	induced	induce	VERB
bam-1791	280	11	muscle	muscle	NOUN
bam-1791	280	12	contraction	contraction	NOUN
bam-1791	280	13	.	.	PUNCT
bam-1791	281	1	cattle	cattle	NOUN
bam-1791	281	2	pseudomyotonia	pseudomyotonia	NOUN
bam-1791	281	3	has	have	AUX
bam-1791	281	4	been	be	AUX
bam-1791	281	5	well	well	ADV
bam-1791	281	6	characterized	characterize	VERB
bam-1791	281	7	at	at	ADP
bam-1791	281	8	both	both	CCONJ
bam-1791	281	9	genetic	genetic	ADJ
bam-1791	281	10	and	and	CCONJ
bam-1791	281	11	biochemical	biochemical	ADJ
bam-1791	281	12	levels	level	NOUN
bam-1791	281	13	.	.	PUNCT
bam-1791	282	1	by	by	ADP
bam-1791	282	2	dna	dna	NOUN
bam-1791	282	3	sequencing	sequencing	NOUN
bam-1791	282	4	of	of	ADP
bam-1791	282	5	affected	affected	ADJ
bam-1791	282	6	calves	calf	NOUN
bam-1791	282	7	,	,	PUNCT
bam-1791	282	8	we	we	PRON
bam-1791	282	9	have	have	AUX
bam-1791	282	10	provided	provide	VERB
bam-1791	282	11	evidence	evidence	NOUN
bam-1791	282	12	of	of	ADP
bam-1791	282	13	mutations	mutation	NOUN
bam-1791	282	14	in	in	ADP
bam-1791	282	15	atp2a1	atp2a1	NOUN
bam-1791	282	16	gene	gene	NOUN
bam-1791	282	17	coding	code	VERB
bam-1791	282	18	for	for	ADP
bam-1791	282	19	sarco(endo)plasmic	sarco(endo)plasmic	ADJ
bam-1791	282	20	reticulum	reticulum	NOUN
bam-1791	282	21	ca2	ca2	PROPN
bam-1791	282	22	+	+	NOUN
bam-1791	282	23	-atpase	-atpase	NOUN
bam-1791	282	24	,	,	PUNCT
bam-1791	282	25	isoform1	isoform1	PROPN
bam-1791	282	26	(	(	PUNCT
bam-1791	282	27	serca1	serca1	PROPN
bam-1791	282	28	)	)	PUNCT
bam-1791	282	29	.	.	PUNCT
bam-1791	283	1	moreover	moreover	ADV
bam-1791	283	2	we	we	PRON
bam-1791	283	3	have	have	AUX
bam-1791	283	4	demonstrated	demonstrate	VERB
bam-1791	283	5	that	that	SCONJ
bam-1791	283	6	cattle	cattle	NOUN
bam-1791	283	7	pathological	pathological	ADJ
bam-1791	283	8	muscles	muscle	NOUN
bam-1791	283	9	are	be	AUX
bam-1791	283	10	characterized	characterize	VERB
bam-1791	283	11	by	by	ADP
bam-1791	283	12	a	a	DET
bam-1791	283	13	selective	selective	ADJ
bam-1791	283	14	reduction	reduction	NOUN
bam-1791	283	15	in	in	ADP
bam-1791	283	16	the	the	DET
bam-1791	283	17	level	level	NOUN
bam-1791	283	18	of	of	ADP
bam-1791	283	19	expression	expression	NOUN
bam-1791	283	20	of	of	ADP
bam-1791	283	21	serca1	serca1	PROPN
bam-1791	283	22	.	.	PUNCT
bam-1791	284	1	on	on	ADP
bam-1791	284	2	the	the	DET
bam-1791	284	3	basis	basis	NOUN
bam-1791	284	4	of	of	ADP
bam-1791	284	5	symptoms	symptom	NOUN
bam-1791	284	6	and	and	CCONJ
bam-1791	284	7	of	of	ADP
bam-1791	284	8	genetic	genetic	ADJ
bam-1791	284	9	and	and	CCONJ
bam-1791	284	10	biochemical	biochemical	ADJ
bam-1791	284	11	confirmations	confirmation	NOUN
bam-1791	284	12	,	,	PUNCT
bam-1791	284	13	cattle	cattle	NOUN
bam-1791	284	14	pseudomyotonia	pseudomyotonia	NOUN
bam-1791	284	15	has	have	AUX
bam-1791	284	16	been	be	AUX
bam-1791	284	17	defined	define	VERB
bam-1791	284	18	as	as	ADP
bam-1791	284	19	the	the	DET
bam-1791	284	20	true	true	ADJ
bam-1791	284	21	counterpart	counterpart	NOUN
bam-1791	284	22	of	of	ADP
bam-1791	284	23	human	human	PROPN
bam-1791	284	24	brody	brody	PROPN
bam-1791	284	25	disease	disease	PROPN
bam-1791	284	26	,	,	PUNCT
bam-1791	284	27	a	a	DET
bam-1791	284	28	rare	rare	ADJ
bam-1791	284	29	inherited	inherit	VERB
bam-1791	284	30	disorder	disorder	NOUN
bam-1791	284	31	of	of	ADP
bam-1791	284	32	skeletal	skeletal	ADJ
bam-1791	284	33	muscle	muscle	NOUN
bam-1791	284	34	due	due	ADP
bam-1791	284	35	to	to	ADP
bam-1791	284	36	a	a	DET
bam-1791	284	37	serca1	serca1	NOUN
bam-1791	284	38	deficiency	deficiency	NOUN
bam-1791	284	39	,	,	PUNCT
bam-1791	284	40	resulting	result	VERB
bam-1791	284	41	from	from	ADP
bam-1791	284	42	a	a	DET
bam-1791	284	43	defect	defect	NOUN
bam-1791	284	44	of	of	ADP
bam-1791	284	45	atp2a1	atp2a1	NOUN
bam-1791	284	46	gene	gene	NOUN
bam-1791	284	47	.	.	PUNCT
bam-1791	285	1	although	although	SCONJ
bam-1791	285	2	for	for	ADP
bam-1791	285	3	both	both	DET
bam-1791	285	4	brody	brody	NOUN
bam-1791	285	5	disease	disease	NOUN
bam-1791	285	6	and	and	CCONJ
bam-1791	285	7	pseudomyotonia	pseudomyotonia	NOUN
bam-1791	285	8	the	the	DET
bam-1791	285	9	selective	selective	ADJ
bam-1791	285	10	reduction	reduction	NOUN
bam-1791	285	11	in	in	ADP
bam-1791	285	12	the	the	DET
bam-1791	285	13	expression	expression	NOUN
bam-1791	285	14	levels	level	NOUN
bam-1791	285	15	of	of	ADP
bam-1791	285	16	serca1	serca1	PROPN
bam-1791	285	17	,	,	PUNCT
bam-1791	285	18	has	have	AUX
bam-1791	285	19	been	be	AUX
bam-1791	285	20	indicated	indicate	VERB
bam-1791	285	21	as	as	ADP
bam-1791	285	22	causative	causative	ADJ
bam-1791	285	23	of	of	ADP
bam-1791	285	24	the	the	DET
bam-1791	285	25	disease	disease	NOUN
bam-1791	285	26	,	,	PUNCT
bam-1791	285	27	the	the	DET
bam-1791	285	28	pathophysiological	pathophysiological	ADJ
bam-1791	285	29	mechanism	mechanism	NOUN
bam-1791	285	30	underlying	underlie	VERB
bam-1791	285	31	this	this	DET
bam-1791	285	32	deficiency	deficiency	NOUN
bam-1791	285	33	has	have	AUX
bam-1791	285	34	not	not	PART
bam-1791	285	35	yet	yet	ADV
bam-1791	285	36	been	be	AUX
bam-1791	285	37	clarified	clarify	VERB
bam-1791	285	38	.	.	PUNCT
bam-1791	286	1	recently	recently	ADV
bam-1791	286	2	,	,	PUNCT
bam-1791	286	3	we	we	PRON
bam-1791	286	4	have	have	AUX
bam-1791	286	5	presented	present	VERB
bam-1791	286	6	the	the	DET
bam-1791	286	7	crystal	crystal	NOUN
bam-1791	286	8	structure	structure	NOUN
bam-1791	286	9	of	of	ADP
bam-1791	286	10	bovine	bovine	PROPN
bam-1791	286	11	serca1	serca1	PROPN
bam-1791	286	12	.	.	PUNCT
bam-1791	287	1	this	this	PRON
bam-1791	287	2	result	result	VERB
bam-1791	287	3	together	together	ADV
bam-1791	287	4	with	with	ADP
bam-1791	287	5	data	datum	NOUN
bam-1791	287	6	on	on	ADP
bam-1791	287	7	the	the	DET
bam-1791	287	8	possible	possible	ADJ
bam-1791	287	9	role	role	NOUN
bam-1791	287	10	of	of	ADP
bam-1791	287	11	the	the	DET
bam-1791	287	12	quality	quality	NOUN
bam-1791	287	13	control	control	NOUN
bam-1791	287	14	system	system	NOUN
bam-1791	287	15	,	,	PUNCT
bam-1791	287	16	ubiquitin	ubiquitin	NOUN
bam-1791	287	17	-	-	PUNCT
bam-1791	287	18	proteasome	proteasome	NOUN
bam-1791	287	19	,	,	PUNCT
bam-1791	287	20	in	in	ADP
bam-1791	287	21	the	the	DET
bam-1791	287	22	reduction	reduction	NOUN
bam-1791	287	23	of	of	ADP
bam-1791	287	24	expression	expression	NOUN
bam-1791	287	25	levels	level	NOUN
bam-1791	287	26	of	of	ADP
bam-1791	287	27	the	the	DET
bam-1791	287	28	mutated	mutate	VERB
bam-1791	287	29	serca1	serca1	NOUN
bam-1791	287	30	,	,	PUNCT
bam-1791	287	31	demonstrate	demonstrate	VERB
bam-1791	287	32	that	that	SCONJ
bam-1791	287	33	a	a	DET
bam-1791	287	34	single	single	ADJ
bam-1791	287	35	mutation	mutation	NOUN
bam-1791	287	36	is	be	AUX
bam-1791	287	37	sufficient	sufficient	ADJ
bam-1791	287	38	to	to	PART
bam-1791	287	39	perturb	perturb	VERB
bam-1791	287	40	the	the	DET
bam-1791	287	41	three	three	NUM
bam-1791	287	42	dimensional	dimensional	ADJ
bam-1791	287	43	structure	structure	NOUN
bam-1791	287	44	of	of	ADP
bam-1791	287	45	serca1	serca1	NOUN
bam-1791	287	46	protein	protein	NOUN
bam-1791	287	47	and	and	CCONJ
bam-1791	287	48	induce	induce	VERB
bam-1791	287	49	a	a	DET
bam-1791	287	50	genetic	genetic	ADJ
bam-1791	287	51	disease	disease	NOUN
bam-1791	287	52	.	.	PUNCT
bam-1791	288	1	this	this	DET
bam-1791	288	2	study	study	NOUN
bam-1791	288	3	reflects	reflect	VERB
bam-1791	288	4	the	the	DET
bam-1791	288	5	enormous	enormous	ADJ
bam-1791	288	6	potential	potential	NOUN
bam-1791	288	7	of	of	ADP
bam-1791	288	8	domestic	domestic	ADJ
bam-1791	288	9	animals	animal	NOUN
bam-1791	288	10	to	to	PART
bam-1791	288	11	gain	gain	VERB
bam-1791	288	12	further	further	ADJ
bam-1791	288	13	insights	insight	NOUN
bam-1791	288	14	into	into	ADP
bam-1791	288	15	human	human	ADJ
bam-1791	288	16	medicine	medicine	NOUN
bam-1791	288	17	.	.	PUNCT
bam-1791	289	1	25	25	NUM
bam-1791	289	2	.	.	PUNCT
bam-1791	290	1	the	the	DET
bam-1791	290	2	adaptations	adaptation	NOUN
bam-1791	290	3	of	of	ADP
bam-1791	290	4	mice	mouse	NOUN
bam-1791	290	5	skeletal	skeletal	ADJ
bam-1791	290	6	muscle	muscle	NOUN
bam-1791	290	7	to	to	ADP
bam-1791	290	8	short	short	ADJ
bam-1791	290	9	term	term	NOUN
bam-1791	290	10	steroid	steroid	PROPN
bam-1791	290	11	administration	administration	PROPN
bam-1791	290	12	agoni	agoni	PROPN
bam-1791	290	13	valentina	valentina	PROPN
bam-1791	290	14	,	,	PUNCT
bam-1791	290	15	canepari	canepari	PROPN
bam-1791	290	16	monica	monica	PROPN
bam-1791	290	17	,	,	PUNCT
bam-1791	290	18	pellegrino	pellegrino	PROPN
bam-1791	290	19	maria	maria	PROPN
bam-1791	290	20	antonietta	antonietta	PROPN
bam-1791	290	21	,	,	PUNCT
bam-1791	290	22	bottinelli	bottinelli	PROPN
bam-1791	290	23	roberto	roberto	PROPN
bam-1791	290	24	università	università	PROPN
bam-1791	290	25	degli	degli	PROPN
bam-1791	290	26	studi	studi	PROPN
bam-1791	290	27	di	di	PROPN
bam-1791	290	28	pavia	pavia	PROPN
bam-1791	290	29	,	,	PUNCT
bam-1791	290	30	dipartimento	dipartimento	ADP
bam-1791	290	31	di	di	NOUN
bam-1791	290	32	medicina	medicina	PROPN
bam-1791	290	33	molecolare	molecolare	VERB
bam-1791	290	34	1	1	NUM
bam-1791	290	35	department	department	NOUN
bam-1791	290	36	of	of	ADP
bam-1791	290	37	molecular	molecular	ADJ
bam-1791	290	38	medicine	medicine	NOUN
bam-1791	290	39	,	,	PUNCT
bam-1791	290	40	university	university	NOUN
bam-1791	290	41	of	of	ADP
bam-1791	290	42	pavia	pavia	PROPN
bam-1791	290	43	,	,	PUNCT
bam-1791	290	44	via	via	ADP
bam-1791	290	45	forlanini	forlanini	NOUN
bam-1791	290	46	6	6	NUM
bam-1791	290	47	,	,	PUNCT
bam-1791	290	48	27100	27100	NUM
bam-1791	290	49	pavia	pavia	NOUN
bam-1791	290	50	,	,	PUNCT
bam-1791	290	51	italy	italy	PROPN
bam-1791	290	52	to	to	PART
bam-1791	290	53	understand	understand	VERB
bam-1791	290	54	the	the	DET
bam-1791	290	55	molecular	molecular	ADJ
bam-1791	290	56	mechanisms	mechanism	NOUN
bam-1791	290	57	underlying	underlie	VERB
bam-1791	290	58	steroid	steroid	NOUN
bam-1791	290	59	myopathy	myopathy	NOUN
bam-1791	290	60	we	we	PRON
bam-1791	290	61	studied	study	VERB
bam-1791	290	62	skeletal	skeletal	ADJ
bam-1791	290	63	muscle	muscle	NOUN
bam-1791	290	64	adaptations	adaptation	NOUN
bam-1791	290	65	to	to	ADP
bam-1791	290	66	dexamethasone	dexamethasone	NOUN
bam-1791	290	67	(	(	PUNCT
bam-1791	290	68	dex	dex	NOUN
bam-1791	290	69	)	)	PUNCT
bam-1791	290	70	administration	administration	NOUN
bam-1791	290	71	(	(	PUNCT
bam-1791	290	72	5	5	NUM
bam-1791	290	73	mg	mg	PROPN
bam-1791	290	74	kg-1	kg-1	NOUN
bam-1791	290	75	day-1	day-1	PRON
bam-1791	290	76	)	)	PUNCT
bam-1791	290	77	in	in	ADP
bam-1791	290	78	adult	adult	NOUN
bam-1791	290	79	mice	mouse	NOUN
bam-1791	290	80	at	at	ADP
bam-1791	290	81	different	different	ADJ
bam-1791	290	82	times	time	NOUN
bam-1791	290	83	(	(	PUNCT
bam-1791	290	84	3	3	NUM
bam-1791	290	85	and	and	CCONJ
bam-1791	290	86	7	7	NUM
bam-1791	290	87	days	day	NOUN
bam-1791	290	88	)	)	PUNCT
bam-1791	290	89	.	.	PUNCT
bam-1791	291	1	we	we	PRON
bam-1791	291	2	analyzed	analyze	VERB
bam-1791	291	3	:	:	PUNCT
bam-1791	291	4	creatine	creatine	PROPN
bam-1791	291	5	kinase	kinase	PROPN
bam-1791	291	6	(	(	PUNCT
bam-1791	291	7	ck	ck	NOUN
bam-1791	291	8	)	)	PUNCT
bam-1791	291	9	serum	serum	NOUN
bam-1791	291	10	levels	level	NOUN
bam-1791	291	11	;	;	PUNCT
bam-1791	291	12	absolute	absolute	ADJ
bam-1791	291	13	and	and	CCONJ
bam-1791	291	14	specific	specific	ADJ
bam-1791	291	15	force	force	NOUN
bam-1791	291	16	development	development	NOUN
bam-1791	291	17	and	and	CCONJ
bam-1791	291	18	fatigue	fatigue	NOUN
bam-1791	291	19	index	index	NOUN
bam-1791	291	20	in	in	ADP
bam-1791	291	21	extensor	extensor	PROPN
bam-1791	291	22	digitorum	digitorum	PROPN
bam-1791	291	23	longus	longus	PROPN
bam-1791	291	24	(	(	PUNCT
bam-1791	291	25	edl	edl	PROPN
bam-1791	291	26	)	)	PUNCT
bam-1791	291	27	and	and	CCONJ
bam-1791	291	28	soleus	soleus	NOUN
bam-1791	291	29	(	(	PUNCT
bam-1791	291	30	s	s	NOUN
bam-1791	291	31	)	)	PUNCT
bam-1791	291	32	isolated	isolate	VERB
bam-1791	291	33	intact	intact	ADJ
bam-1791	291	34	muscles	muscle	NOUN
bam-1791	291	35	;	;	PUNCT
bam-1791	291	36	mhc	mhc	PROPN
bam-1791	291	37	isoform	isoform	NOUN
bam-1791	291	38	composition	composition	NOUN
bam-1791	291	39	;	;	PUNCT
bam-1791	291	40	muscle	muscle	NOUN
bam-1791	291	41	fibres	fibre	VERB
bam-1791	291	42	cross	cross	ADJ
bam-1791	291	43	-	-	ADJ
bam-1791	291	44	sectional	sectional	ADJ
bam-1791	291	45	area	area	NOUN
bam-1791	291	46	(	(	PUNCT
bam-1791	291	47	csa	csa	PROPN
bam-1791	291	48	)	)	PUNCT
bam-1791	291	49	;	;	PUNCT
bam-1791	291	50	master	master	NOUN
bam-1791	291	51	controllers	controller	NOUN
bam-1791	291	52	of	of	ADP
bam-1791	291	53	muscle	muscle	NOUN
bam-1791	291	54	protein	protein	NOUN
bam-1791	291	55	breakdown	breakdown	NOUN
bam-1791	291	56	(	(	PUNCT
bam-1791	291	57	mpb	mpb	NOUN
bam-1791	291	58	)	)	PUNCT
bam-1791	291	59	(	(	PUNCT
bam-1791	291	60	murf-1	murf-1	PROPN
bam-1791	291	61	,	,	PUNCT
bam-1791	291	62	atrogin-1	atrogin-1	NUM
bam-1791	291	63	)	)	PUNCT
bam-1791	291	64	;	;	PUNCT
bam-1791	291	65	master	master	NOUN
bam-1791	291	66	controllers	controller	NOUN
bam-1791	291	67	of	of	ADP
bam-1791	291	68	autophagy	autophagy	NOUN
bam-1791	291	69	ix	ix	ADP
bam-1791	291	70	iim	iim	PROPN
bam-1791	291	71	meeting	meeting	NOUN
bam-1791	291	72	,	,	PUNCT
bam-1791	291	73	acaya	acaya	NOUN
bam-1791	291	74	(	(	PUNCT
bam-1791	291	75	lecce	lecce	PROPN
bam-1791	291	76	)	)	PUNCT
bam-1791	291	77	,	,	PUNCT
bam-1791	291	78	october	october	PROPN
bam-1791	291	79	12	12	NUM
bam-1791	291	80	-	-	SYM
bam-1791	291	81	14	14	NUM
bam-1791	291	82	,	,	PUNCT
bam-1791	291	83	2012	2012	NUM
bam-1791	291	84	european	european	PROPN
bam-1791	291	85	journal	journal	PROPN
bam-1791	291	86	translational	translational	ADJ
bam-1791	291	87	myology	myology	NOUN
bam-1791	291	88	basic	basic	ADJ
bam-1791	291	89	applied	apply	VERB
bam-1791	291	90	myology	myology	NOUN
bam-1791	291	91	2012	2012	NUM
bam-1791	291	92	;	;	PUNCT
bam-1791	291	93	22(1&2	22(1&2	NUM
bam-1791	291	94	):	):	PUNCT
bam-1791	291	95	xxx	xxx	NOUN
bam-1791	291	96	-	-	PUNCT
bam-1791	291	97	xxx	xxx	NOUN
bam-1791	291	98	31	31	NUM
bam-1791	291	99	(	(	PUNCT
bam-1791	291	100	beclin-1	beclin-1	PROPN
bam-1791	291	101	,	,	PUNCT
bam-1791	291	102	p62	p62	NOUN
bam-1791	291	103	)	)	PUNCT
bam-1791	291	104	7	7	NUM
bam-1791	291	105	)	)	PUNCT
bam-1791	291	106	;	;	PUNCT
bam-1791	291	107	master	master	NOUN
bam-1791	291	108	controller	controller	NOUN
bam-1791	291	109	of	of	ADP
bam-1791	291	110	metabolism	metabolism	NOUN
bam-1791	291	111	(	(	PUNCT
bam-1791	291	112	pgc-1alpha	pgc-1alpha	NOUN
bam-1791	291	113	)	)	PUNCT
bam-1791	291	114	,	,	PUNCT
bam-1791	291	115	and	and	CCONJ
bam-1791	291	116	citrate	citrate	NOUN
bam-1791	291	117	synthase	synthase	NOUN
bam-1791	291	118	(	(	PUNCT
bam-1791	291	119	cs	cs	PROPN
bam-1791	291	120	)	)	PUNCT
bam-1791	291	121	and	and	CCONJ
bam-1791	291	122	atp	atp	NOUN
bam-1791	291	123	synthase	synthase	NOUN
bam-1791	291	124	expression	expression	NOUN
bam-1791	291	125	.	.	PUNCT
bam-1791	292	1	all	all	DET
bam-1791	292	2	determinations	determination	NOUN
bam-1791	292	3	,	,	PUNCT
bam-1791	292	4	but	but	CCONJ
bam-1791	292	5	those	those	PRON
bam-1791	292	6	performed	perform	VERB
bam-1791	292	7	in	in	ADP
bam-1791	292	8	intact	intact	ADJ
bam-1791	292	9	s	s	NOUN
bam-1791	292	10	and	and	CCONJ
bam-1791	292	11	edl	edl	PROPN
bam-1791	292	12	muscle	muscle	NOUN
bam-1791	292	13	were	be	AUX
bam-1791	292	14	done	do	VERB
bam-1791	292	15	in	in	ADP
bam-1791	292	16	vastus	vastus	NOUN
bam-1791	292	17	lateralis	laterali	NOUN
bam-1791	292	18	muscle	muscle	NOUN
bam-1791	292	19	.	.	PUNCT
bam-1791	293	1	significant	significant	ADJ
bam-1791	293	2	fibers	fiber	NOUN
bam-1791	293	3	atrophy	atrophy	NOUN
bam-1791	293	4	was	be	AUX
bam-1791	293	5	observed	observe	VERB
bam-1791	293	6	at	at	ADP
bam-1791	293	7	7	7	NUM
bam-1791	293	8	days	day	NOUN
bam-1791	293	9	dex	dex	NOUN
bam-1791	293	10	(	(	PUNCT
bam-1791	293	11	14	14	NUM
bam-1791	293	12	%	%	NOUN
bam-1791	293	13	)	)	PUNCT
bam-1791	293	14	only	only	ADV
bam-1791	293	15	;	;	PUNCT
bam-1791	293	16	no	no	DET
bam-1791	293	17	significant	significant	ADJ
bam-1791	293	18	change	change	NOUN
bam-1791	293	19	of	of	ADP
bam-1791	293	20	the	the	DET
bam-1791	293	21	functional	functional	ADJ
bam-1791	293	22	parameters	parameter	NOUN
bam-1791	293	23	and	and	CCONJ
bam-1791	293	24	no	no	DET
bam-1791	293	25	mhc	mhc	NOUN
bam-1791	293	26	isoforms	isoform	VERB
bam-1791	293	27	transition	transition	NOUN
bam-1791	293	28	were	be	AUX
bam-1791	293	29	observed	observe	VERB
bam-1791	293	30	both	both	CCONJ
bam-1791	293	31	at	at	ADP
bam-1791	293	32	3	3	NUM
bam-1791	293	33	and	and	CCONJ
bam-1791	293	34	7	7	NUM
bam-1791	293	35	days	day	NOUN
bam-1791	293	36	dex	dex	NOUN
bam-1791	293	37	,	,	PUNCT
bam-1791	293	38	a	a	DET
bam-1791	293	39	significant	significant	ADJ
bam-1791	293	40	up	up	NOUN
bam-1791	293	41	-	-	PUNCT
bam-1791	293	42	regulation	regulation	NOUN
bam-1791	293	43	of	of	ADP
bam-1791	293	44	mpb	mpb	NOUN
bam-1791	293	45	(	(	PUNCT
bam-1791	293	46	murf1	murf1	NOUN
bam-1791	293	47	)	)	PUNCT
bam-1791	293	48	was	be	AUX
bam-1791	293	49	found	find	VERB
bam-1791	293	50	at	at	ADP
bam-1791	293	51	7	7	NUM
bam-1791	293	52	days	day	NOUN
bam-1791	293	53	dex	dex	NOUN
bam-1791	293	54	while	while	SCONJ
bam-1791	293	55	no	no	DET
bam-1791	293	56	changes	change	NOUN
bam-1791	293	57	were	be	AUX
bam-1791	293	58	observed	observe	VERB
bam-1791	293	59	in	in	ADP
bam-1791	293	60	autophagy	autophagy	ADJ
bam-1791	293	61	system	system	NOUN
bam-1791	293	62	(	(	PUNCT
bam-1791	293	63	p62	p62	NOUN
bam-1791	293	64	,	,	PUNCT
bam-1791	293	65	beclin1	beclin1	NOUN
bam-1791	293	66	)	)	PUNCT
bam-1791	293	67	both	both	PRON
bam-1791	293	68	at	at	ADP
bam-1791	293	69	3	3	NUM
bam-1791	293	70	and	and	CCONJ
bam-1791	293	71	7	7	NUM
bam-1791	293	72	days	day	NOUN
bam-1791	293	73	dex	dex	NOUN
bam-1791	293	74	.	.	PUNCT
bam-1791	294	1	moreover	moreover	ADV
bam-1791	294	2	,	,	PUNCT
bam-1791	294	3	a	a	DET
bam-1791	294	4	significant	significant	ADJ
bam-1791	294	5	increase	increase	NOUN
bam-1791	294	6	of	of	ADP
bam-1791	294	7	cs	cs	PROPN
bam-1791	294	8	and	and	CCONJ
bam-1791	294	9	atp	atp	PROPN
bam-1791	294	10	synthase	synthase	NOUN
bam-1791	294	11	expression	expression	NOUN
bam-1791	294	12	were	be	AUX
bam-1791	294	13	observed	observe	VERB
bam-1791	294	14	at	at	ADP
bam-1791	294	15	3	3	NUM
bam-1791	294	16	days	day	NOUN
bam-1791	294	17	dex	dex	NOUN
bam-1791	294	18	only	only	ADV
bam-1791	294	19	,	,	PUNCT
bam-1791	294	20	without	without	ADP
bam-1791	294	21	any	any	DET
bam-1791	294	22	change	change	NOUN
bam-1791	294	23	in	in	ADP
bam-1791	294	24	pgc-1	pgc-1	NOUN
bam-1791	294	25	alpha	alpha	NOUN
bam-1791	294	26	expression	expression	NOUN
bam-1791	294	27	.	.	PUNCT
bam-1791	295	1	our	our	PRON
bam-1791	295	2	preliminary	preliminary	ADJ
bam-1791	295	3	data	datum	NOUN
bam-1791	295	4	suggest	suggest	VERB
bam-1791	295	5	that	that	SCONJ
bam-1791	295	6	in	in	ADP
bam-1791	295	7	the	the	DET
bam-1791	295	8	early	early	ADJ
bam-1791	295	9	phases	phase	NOUN
bam-1791	295	10	of	of	ADP
bam-1791	295	11	myopathy	myopathy	ADJ
bam-1791	295	12	,	,	PUNCT
bam-1791	295	13	atrophy	atrophy	NOUN
bam-1791	295	14	is	be	AUX
bam-1791	295	15	supported	support	VERB
bam-1791	295	16	by	by	ADP
bam-1791	295	17	the	the	DET
bam-1791	295	18	activation	activation	NOUN
bam-1791	295	19	of	of	ADP
bam-1791	295	20	the	the	DET
bam-1791	295	21	ubiquitin	ubiquitin	ADJ
bam-1791	295	22	-	-	PUNCT
bam-1791	295	23	proteasome	proteasome	NOUN
bam-1791	295	24	system	system	NOUN
bam-1791	295	25	and	and	CCONJ
bam-1791	295	26	that	that	SCONJ
bam-1791	295	27	it	it	PRON
bam-1791	295	28	is	be	AUX
bam-1791	295	29	not	not	PART
bam-1791	295	30	related	relate	VERB
bam-1791	295	31	to	to	ADP
bam-1791	295	32	a	a	DET
bam-1791	295	33	mitochondrial	mitochondrial	ADJ
bam-1791	295	34	dysfunction	dysfunction	NOUN
bam-1791	295	35	.	.	PUNCT
bam-1791	296	1	26	26	NUM
bam-1791	296	2	.	.	PUNCT
bam-1791	297	1	akt	akt	PROPN
bam-1791	297	2	pathway	pathway	NOUN
bam-1791	297	3	in	in	ADP
bam-1791	297	4	sbma	sbma	PROPN
bam-1791	297	5	skeletal	skeletal	ADJ
bam-1791	297	6	muscle	muscle	NOUN
bam-1791	297	7	a.	a.	NOUN
bam-1791	297	8	rocchi	rocchi	PROPN
bam-1791	297	9	;	;	PUNCT
bam-1791	297	10	m.	m.	NOUN
bam-1791	297	11	pellegrini	pellegrini	PROPN
bam-1791	297	12	;	;	PUNCT
bam-1791	297	13	m.	m.	NOUN
bam-1791	297	14	pennuto	pennuto	PROPN
bam-1791	297	15	neuroscience	neuroscience	NOUN
bam-1791	297	16	and	and	CCONJ
bam-1791	297	17	brain	brain	NOUN
bam-1791	297	18	technologies	technology	NOUN
bam-1791	297	19	,	,	PUNCT
bam-1791	297	20	fondazione	fondazione	X
bam-1791	297	21	istituto	istituto	X
bam-1791	297	22	italiano	italiano	PROPN
bam-1791	297	23	di	di	X
bam-1791	297	24	tecnologia	tecnologia	PROPN
bam-1791	297	25	,	,	PUNCT
bam-1791	297	26	genova	genova	X
bam-1791	297	27	spinal	spinal	NOUN
bam-1791	297	28	and	and	CCONJ
bam-1791	297	29	bulbar	bulbar	ADJ
bam-1791	297	30	muscular	muscular	ADJ
bam-1791	297	31	atrophy	atrophy	NOUN
bam-1791	297	32	(	(	PUNCT
bam-1791	297	33	sbma	sbma	PROPN
bam-1791	297	34	)	)	PUNCT
bam-1791	297	35	,	,	PUNCT
bam-1791	297	36	also	also	ADV
bam-1791	297	37	known	know	VERB
bam-1791	297	38	as	as	ADP
bam-1791	297	39	kennedy	kennedy	PROPN
bam-1791	297	40	’s	’s	PART
bam-1791	297	41	disease	disease	NOUN
bam-1791	297	42	,	,	PUNCT
bam-1791	297	43	is	be	AUX
bam-1791	297	44	a	a	DET
bam-1791	297	45	rare	rare	ADJ
bam-1791	297	46	inherited	inherit	VERB
bam-1791	297	47	neuromuscular	neuromuscular	ADJ
bam-1791	297	48	disease	disease	NOUN
bam-1791	297	49	characterized	characterize	VERB
bam-1791	297	50	by	by	ADP
bam-1791	297	51	the	the	DET
bam-1791	297	52	loss	loss	NOUN
bam-1791	297	53	of	of	ADP
bam-1791	297	54	lower	low	ADJ
bam-1791	297	55	motor	motor	NOUN
bam-1791	297	56	neurons	neuron	NOUN
bam-1791	297	57	in	in	ADP
bam-1791	297	58	the	the	DET
bam-1791	297	59	brainstem	brainstem	NOUN
bam-1791	297	60	and	and	CCONJ
bam-1791	297	61	spinal	spinal	ADJ
bam-1791	297	62	cord	cord	NOUN
bam-1791	297	63	and	and	CCONJ
bam-1791	297	64	skeletal	skeletal	ADJ
bam-1791	297	65	muscle	muscle	NOUN
bam-1791	297	66	weakness	weakness	NOUN
bam-1791	297	67	and	and	CCONJ
bam-1791	297	68	atrophy	atrophy	NOUN
bam-1791	297	69	.	.	PUNCT
bam-1791	298	1	the	the	DET
bam-1791	298	2	disease	disease	NOUN
bam-1791	298	3	is	be	AUX
bam-1791	298	4	caused	cause	VERB
bam-1791	298	5	by	by	ADP
bam-1791	298	6	expansion	expansion	NOUN
bam-1791	298	7	of	of	ADP
bam-1791	298	8	a	a	DET
bam-1791	298	9	polyglutamine	polyglutamine	NOUN
bam-1791	298	10	tract	tract	NOUN
bam-1791	298	11	(	(	PUNCT
bam-1791	298	12	polyq	polyq	NOUN
bam-1791	298	13	)	)	PUNCT
bam-1791	298	14	in	in	ADP
bam-1791	298	15	the	the	DET
bam-1791	298	16	gene	gene	NOUN
bam-1791	298	17	coding	code	VERB
bam-1791	298	18	for	for	ADP
bam-1791	298	19	androgen	androgen	NOUN
bam-1791	298	20	receptor	receptor	NOUN
bam-1791	298	21	(	(	PUNCT
bam-1791	298	22	ar	ar	NOUN
bam-1791	298	23	)	)	PUNCT
bam-1791	298	24	.	.	PUNCT
bam-1791	299	1	sbma	sbma	PROPN
bam-1791	299	2	fully	fully	ADV
bam-1791	299	3	affects	affect	VERB
bam-1791	299	4	only	only	ADV
bam-1791	299	5	males	male	NOUN
bam-1791	299	6	.	.	PUNCT
bam-1791	300	1	females	female	NOUN
bam-1791	300	2	even	even	ADV
bam-1791	300	3	if	if	SCONJ
bam-1791	300	4	homozygous	homozygous	ADJ
bam-1791	300	5	for	for	ADP
bam-1791	300	6	the	the	DET
bam-1791	300	7	mutation	mutation	NOUN
bam-1791	300	8	have	have	VERB
bam-1791	300	9	mild	mild	ADJ
bam-1791	300	10	disease	disease	NOUN
bam-1791	300	11	manifestations	manifestation	NOUN
bam-1791	300	12	.	.	PUNCT
bam-1791	301	1	the	the	DET
bam-1791	301	2	sex	sex	NOUN
bam-1791	301	3	-	-	PUNCT
bam-1791	301	4	dependent	dependent	ADJ
bam-1791	301	5	nature	nature	NOUN
bam-1791	301	6	of	of	ADP
bam-1791	301	7	sbma	sbma	PROPN
bam-1791	301	8	is	be	AUX
bam-1791	301	9	due	due	ADJ
bam-1791	301	10	to	to	ADP
bam-1791	301	11	the	the	DET
bam-1791	301	12	fact	fact	NOUN
bam-1791	301	13	that	that	SCONJ
bam-1791	301	14	polyq	polyq	NOUN
bam-1791	301	15	-	-	PUNCT
bam-1791	301	16	ar	ar	NOUN
bam-1791	301	17	is	be	AUX
bam-1791	301	18	converted	convert	VERB
bam-1791	301	19	to	to	ADP
bam-1791	301	20	a	a	DET
bam-1791	301	21	toxic	toxic	ADJ
bam-1791	301	22	species	specie	NOUN
bam-1791	301	23	by	by	ADP
bam-1791	301	24	binding	bind	VERB
bam-1791	301	25	to	to	ADP
bam-1791	301	26	its	its	PRON
bam-1791	301	27	natural	natural	ADJ
bam-1791	301	28	ligand	ligand	NOUN
bam-1791	301	29	,	,	PUNCT
bam-1791	301	30	testosterone	testosterone	NOUN
bam-1791	301	31	.	.	PUNCT
bam-1791	302	1	sbma	sbma	PROPN
bam-1791	302	2	has	have	AUX
bam-1791	302	3	long	long	ADV
bam-1791	302	4	been	be	AUX
bam-1791	302	5	considered	consider	VERB
bam-1791	302	6	a	a	DET
bam-1791	302	7	pure	pure	ADJ
bam-1791	302	8	motor	motor	NOUN
bam-1791	302	9	neuron	neuron	NOUN
bam-1791	302	10	disease	disease	PROPN
bam-1791	302	11	.	.	PUNCT
bam-1791	303	1	according	accord	VERB
bam-1791	303	2	to	to	ADP
bam-1791	303	3	this	this	DET
bam-1791	303	4	model	model	NOUN
bam-1791	303	5	,	,	PUNCT
bam-1791	303	6	polyq	polyq	NOUN
bam-1791	303	7	-	-	PUNCT
bam-1791	303	8	ar	ar	NOUN
bam-1791	303	9	acts	act	NOUN
bam-1791	303	10	in	in	ADP
bam-1791	303	11	motor	motor	NOUN
bam-1791	303	12	neurons	neuron	NOUN
bam-1791	303	13	to	to	PART
bam-1791	303	14	cause	cause	VERB
bam-1791	303	15	their	their	PRON
bam-1791	303	16	death	death	NOUN
bam-1791	303	17	,	,	PUNCT
bam-1791	303	18	resulting	result	VERB
bam-1791	303	19	in	in	ADP
bam-1791	303	20	denervation	denervation	NOUN
bam-1791	303	21	-	-	PUNCT
bam-1791	303	22	induced	induce	VERB
bam-1791	303	23	atrophy	atrophy	NOUN
bam-1791	303	24	of	of	ADP
bam-1791	303	25	skeletal	skeletal	ADJ
bam-1791	303	26	muscles	muscle	NOUN
bam-1791	303	27	and	and	CCONJ
bam-1791	303	28	loss	loss	NOUN
bam-1791	303	29	of	of	ADP
bam-1791	303	30	motor	motor	NOUN
bam-1791	303	31	function	function	NOUN
bam-1791	303	32	.	.	PUNCT
bam-1791	304	1	however	however	ADV
bam-1791	304	2	,	,	PUNCT
bam-1791	304	3	there	there	PRON
bam-1791	304	4	is	be	VERB
bam-1791	304	5	clinical	clinical	ADJ
bam-1791	304	6	and	and	CCONJ
bam-1791	304	7	experimental	experimental	ADJ
bam-1791	304	8	evidence	evidence	NOUN
bam-1791	304	9	suggesting	suggest	VERB
bam-1791	304	10	a	a	DET
bam-1791	304	11	primary	primary	ADJ
bam-1791	304	12	role	role	NOUN
bam-1791	304	13	for	for	ADP
bam-1791	304	14	skeletal	skeletal	ADJ
bam-1791	304	15	muscle	muscle	NOUN
bam-1791	304	16	in	in	ADP
bam-1791	304	17	disease	disease	NOUN
bam-1791	304	18	induction	induction	NOUN
bam-1791	304	19	and	and	CCONJ
bam-1791	304	20	progression	progression	NOUN
bam-1791	304	21	.	.	PUNCT
bam-1791	305	1	we	we	PRON
bam-1791	305	2	have	have	AUX
bam-1791	305	3	previously	previously	ADV
bam-1791	305	4	shown	show	VERB
bam-1791	305	5	that	that	SCONJ
bam-1791	305	6	post	post	ADJ
bam-1791	305	7	-	-	ADJ
bam-1791	305	8	translational	translational	ADJ
bam-1791	305	9	modifications	modification	NOUN
bam-1791	305	10	influence	influence	VERB
bam-1791	305	11	the	the	DET
bam-1791	305	12	neurotoxicity	neurotoxicity	NOUN
bam-1791	305	13	of	of	ADP
bam-1791	305	14	polyq	polyq	NOUN
bam-1791	305	15	-	-	PUNCT
bam-1791	305	16	ar	ar	NOUN
bam-1791	305	17	.	.	PROPN
bam-1791	305	18	in	in	ADP
bam-1791	305	19	particular	particular	ADJ
bam-1791	305	20	,	,	PUNCT
bam-1791	305	21	we	we	PRON
bam-1791	305	22	have	have	AUX
bam-1791	305	23	previously	previously	ADV
bam-1791	305	24	shown	show	VERB
bam-1791	305	25	that	that	SCONJ
bam-1791	305	26	akt	akt	PROPN
bam-1791	305	27	-	-	PUNCT
bam-1791	305	28	mediated	mediate	VERB
bam-1791	305	29	phosphorylation	phosphorylation	NOUN
bam-1791	305	30	of	of	ADP
bam-1791	305	31	polyq	polyq	NOUN
bam-1791	305	32	-	-	PUNCT
bam-1791	305	33	ar	ar	NOUN
bam-1791	305	34	protects	protect	NOUN
bam-1791	305	35	against	against	ADP
bam-1791	305	36	toxicity	toxicity	NOUN
bam-1791	305	37	by	by	ADP
bam-1791	305	38	promoting	promote	VERB
bam-1791	305	39	protein	protein	NOUN
bam-1791	305	40	degradation	degradation	NOUN
bam-1791	305	41	through	through	ADP
bam-1791	305	42	the	the	DET
bam-1791	305	43	proteasome	proteasome	NOUN
bam-1791	305	44	.	.	PUNCT
bam-1791	306	1	in	in	ADP
bam-1791	306	2	order	order	NOUN
bam-1791	306	3	to	to	PART
bam-1791	306	4	describe	describe	VERB
bam-1791	306	5	how	how	SCONJ
bam-1791	306	6	akt	akt	PROPN
bam-1791	306	7	signaling	signal	VERB
bam-1791	306	8	is	be	AUX
bam-1791	306	9	regulated	regulate	VERB
bam-1791	306	10	in	in	ADP
bam-1791	306	11	vivo	vivo	NOUN
bam-1791	306	12	,	,	PUNCT
bam-1791	306	13	we	we	PRON
bam-1791	306	14	performed	perform	VERB
bam-1791	306	15	biochemical	biochemical	ADJ
bam-1791	306	16	analysis	analysis	NOUN
bam-1791	306	17	to	to	PART
bam-1791	306	18	measure	measure	VERB
bam-1791	306	19	the	the	DET
bam-1791	306	20	level	level	NOUN
bam-1791	306	21	of	of	ADP
bam-1791	306	22	activity	activity	NOUN
bam-1791	306	23	of	of	ADP
bam-1791	306	24	akt	akt	PROPN
bam-1791	306	25	and	and	CCONJ
bam-1791	306	26	several	several	ADJ
bam-1791	306	27	of	of	ADP
bam-1791	306	28	its	its	PRON
bam-1791	306	29	downstream	downstream	ADJ
bam-1791	306	30	targets	target	NOUN
bam-1791	306	31	,	,	PUNCT
bam-1791	306	32	such	such	ADJ
bam-1791	306	33	as	as	ADP
bam-1791	306	34	gsk-3beta	gsk-3beta	NOUN
bam-1791	306	35	,	,	PUNCT
bam-1791	306	36	mtor	mtor	NOUN
bam-1791	306	37	,	,	PUNCT
bam-1791	306	38	p70s6k	p70s6k	PROPN
bam-1791	306	39	and	and	CCONJ
bam-1791	306	40	4e	4e	PROPN
bam-1791	306	41	-	-	PUNCT
bam-1791	306	42	bp1	bp1	PROPN
bam-1791	306	43	in	in	ADP
bam-1791	306	44	a	a	DET
bam-1791	306	45	knock	knock	VERB
bam-1791	306	46	-	-	PUNCT
bam-1791	306	47	in	in	ADP
bam-1791	306	48	mouse	mouse	NOUN
bam-1791	306	49	model	model	NOUN
bam-1791	306	50	of	of	ADP
bam-1791	306	51	sbma	sbma	PROPN
bam-1791	306	52	.	.	PUNCT
bam-1791	307	1	our	our	PRON
bam-1791	307	2	data	datum	NOUN
bam-1791	307	3	suggest	suggest	VERB
bam-1791	307	4	that	that	SCONJ
bam-1791	307	5	akt	akt	PROPN
bam-1791	307	6	signaling	signal	VERB
bam-1791	307	7	pathway	pathway	NOUN
bam-1791	307	8	is	be	AUX
bam-1791	307	9	altered	alter	VERB
bam-1791	307	10	during	during	ADP
bam-1791	307	11	sbma	sbma	ADJ
bam-1791	307	12	progression	progression	NOUN
bam-1791	307	13	.	.	PUNCT
bam-1791	308	1	27	27	NUM
bam-1791	308	2	.	.	PUNCT
bam-1791	309	1	role	role	NOUN
bam-1791	309	2	of	of	ADP
bam-1791	309	3	the	the	DET
bam-1791	309	4	cell	cell	NOUN
bam-1791	309	5	’s	’s	PART
bam-1791	309	6	quality	quality	NOUN
bam-1791	309	7	control	control	NOUN
bam-1791	309	8	system	system	NOUN
bam-1791	309	9	in	in	ADP
bam-1791	309	10	the	the	DET
bam-1791	309	11	pathogenesis	pathogenesis	NOUN
bam-1791	309	12	of	of	ADP
bam-1791	309	13	lgmd-2d	lgmd-2d	PUNCT
bam-1791	309	14	and	and	CCONJ
bam-1791	309	15	brody	brody	NOUN
bam-1791	309	16	disease	disease	NOUN
bam-1791	309	17	.	.	PUNCT
bam-1791	310	1	elisa	elisa	PROPN
bam-1791	310	2	bianchini1	bianchini1	PROPN
bam-1791	310	3	,	,	PUNCT
bam-1791	310	4	roberta	roberta	PROPN
bam-1791	310	5	sacchetto2	sacchetto2	PROPN
bam-1791	310	6	,	,	PUNCT
bam-1791	310	7	charlotte	charlotte	PROPN
bam-1791	310	8	merckx1	merckx1	PROPN
bam-1791	310	9	,	,	PUNCT
bam-1791	310	10	romeo	romeo	PROPN
bam-1791	310	11	betto1	betto1	PROPN
bam-1791	310	12	-	-	PUNCT
bam-1791	310	13	3	3	NUM
bam-1791	310	14	and	and	CCONJ
bam-1791	310	15	dorianna	dorianna	NOUN
bam-1791	310	16	sandonà1	sandonà1	PROPN
bam-1791	310	17	1department	1department	NUM
bam-1791	310	18	of	of	ADP
bam-1791	310	19	biomedical	biomedical	ADJ
bam-1791	310	20	sciences	science	NOUN
bam-1791	310	21	,	,	PUNCT
bam-1791	310	22	2department	2department	NUM
bam-1791	310	23	of	of	ADP
bam-1791	310	24	comparative	comparative	ADJ
bam-1791	310	25	biomedicine	biomedicine	NOUN
bam-1791	310	26	and	and	CCONJ
bam-1791	310	27	food	food	NOUN
bam-1791	310	28	science	science	NOUN
bam-1791	310	29	,	,	PUNCT
bam-1791	310	30	3cnr	3cnr	NUM
bam-1791	310	31	institute	institute	NOUN
bam-1791	310	32	of	of	ADP
bam-1791	310	33	neuroscience	neuroscience	NOUN
bam-1791	310	34	unfolded	unfold	VERB
bam-1791	310	35	protein	protein	NOUN
bam-1791	310	36	diseases	disease	NOUN
bam-1791	310	37	(	(	PUNCT
bam-1791	310	38	upds	upds	NOUN
bam-1791	310	39	)	)	PUNCT
bam-1791	310	40	are	be	AUX
bam-1791	310	41	genetic	genetic	ADJ
bam-1791	310	42	disorders	disorder	NOUN
bam-1791	310	43	in	in	ADP
bam-1791	310	44	which	which	PRON
bam-1791	310	45	gene	gene	NOUN
bam-1791	310	46	mutations	mutation	NOUN
bam-1791	310	47	result	result	VERB
bam-1791	310	48	in	in	ADP
bam-1791	310	49	unfolded	unfolded	ADJ
bam-1791	310	50	or	or	CCONJ
bam-1791	310	51	misfolded	misfolde	VERB
bam-1791	310	52	proteins	protein	NOUN
bam-1791	310	53	that	that	PRON
bam-1791	310	54	either	either	CCONJ
bam-1791	310	55	aggregate	aggregate	VERB
bam-1791	310	56	or	or	CCONJ
bam-1791	310	57	are	be	AUX
bam-1791	310	58	prematurely	prematurely	ADV
bam-1791	310	59	disposed	dispose	VERB
bam-1791	310	60	of	of	ADP
bam-1791	310	61	by	by	ADP
bam-1791	310	62	the	the	DET
bam-1791	310	63	quality	quality	NOUN
bam-1791	310	64	control	control	NOUN
bam-1791	310	65	system	system	NOUN
bam-1791	310	66	(	(	PUNCT
bam-1791	310	67	qcs	qcs	NOUN
bam-1791	310	68	)	)	PUNCT
bam-1791	310	69	,	,	PUNCT
bam-1791	310	70	although	although	SCONJ
bam-1791	310	71	,	,	PUNCT
bam-1791	310	72	often	often	ADV
bam-1791	310	73	,	,	PUNCT
bam-1791	310	74	their	their	PRON
bam-1791	310	75	function	function	NOUN
bam-1791	310	76	is	be	AUX
bam-1791	310	77	only	only	ADV
bam-1791	310	78	partially	partially	ADV
bam-1791	310	79	impaired	impaired	ADJ
bam-1791	310	80	.	.	PUNCT
bam-1791	311	1	type	type	NOUN
bam-1791	311	2	2d	2d	NUM
bam-1791	311	3	limb	limb	NOUN
bam-1791	311	4	girdle	girdle	VERB
bam-1791	311	5	muscular	muscular	ADJ
bam-1791	311	6	dystrophy	dystrophy	NOUN
bam-1791	311	7	(	(	PUNCT
bam-1791	311	8	lgmd-2d	lgmd-2d	PUNCT
bam-1791	311	9	)	)	PUNCT
bam-1791	311	10	is	be	AUX
bam-1791	311	11	caused	cause	VERB
bam-1791	311	12	by	by	ADP
bam-1791	311	13	mutations	mutation	NOUN
bam-1791	311	14	in	in	ADP
bam-1791	311	15	α	α	NOUN
bam-1791	311	16	-	-	ADJ
bam-1791	311	17	sarcoglycan	sarcoglycan	ADJ
bam-1791	311	18	,	,	PUNCT
bam-1791	311	19	a	a	DET
bam-1791	311	20	protein	protein	NOUN
bam-1791	311	21	that	that	PRON
bam-1791	311	22	,	,	PUNCT
bam-1791	311	23	together	together	ADV
bam-1791	311	24	with	with	ADP
bam-1791	311	25	β-	β-	PROPN
bam-1791	311	26	,	,	PUNCT
bam-1791	311	27	γand	γand	NOUN
bam-1791	311	28	δ	δ	PROPN
bam-1791	311	29	-	-	ADJ
bam-1791	311	30	sarcoglycan	sarcoglycan	ADJ
bam-1791	311	31	,	,	PUNCT
bam-1791	311	32	forms	form	VERB
bam-1791	311	33	a	a	DET
bam-1791	311	34	structural	structural	ADJ
bam-1791	311	35	and	and	CCONJ
bam-1791	311	36	signaling	signal	VERB
bam-1791	311	37	complex	complex	NOUN
bam-1791	311	38	in	in	ADP
bam-1791	311	39	the	the	DET
bam-1791	311	40	sarcolemma	sarcolemma	NOUN
bam-1791	311	41	of	of	ADP
bam-1791	311	42	striated	striated	ADJ
bam-1791	311	43	muscle	muscle	NOUN
bam-1791	311	44	cells	cell	NOUN
bam-1791	311	45	.	.	PUNCT
bam-1791	312	1	lgmd-2d	lgmd-2d	PUNCT
bam-1791	312	2	can	can	AUX
bam-1791	312	3	be	be	AUX
bam-1791	312	4	considered	consider	VERB
bam-1791	312	5	an	an	DET
bam-1791	312	6	upd	upd	NOUN
bam-1791	312	7	as	as	ADP
bam-1791	312	8	α	α	NOUN
bam-1791	312	9	-	-	ADJ
bam-1791	312	10	sarcoglycan	sarcoglycan	ADJ
bam-1791	312	11	mutants	mutant	NOUN
bam-1791	312	12	,	,	PUNCT
bam-1791	312	13	being	be	AUX
bam-1791	312	14	misfolded	misfolde	VERB
bam-1791	312	15	,	,	PUNCT
bam-1791	312	16	are	be	AUX
bam-1791	312	17	intercepted	intercept	VERB
bam-1791	312	18	by	by	ADP
bam-1791	312	19	qcs	qcs	PROPN
bam-1791	312	20	and	and	CCONJ
bam-1791	312	21	degraded	degrade	VERB
bam-1791	312	22	by	by	ADP
bam-1791	312	23	the	the	DET
bam-1791	312	24	ubiquitin	ubiquitin	ADJ
bam-1791	312	25	-	-	PUNCT
bam-1791	312	26	proteasome	proteasome	NOUN
bam-1791	312	27	system	system	NOUN
bam-1791	312	28	.	.	PUNCT
bam-1791	313	1	brody	brody	PROPN
bam-1791	313	2	’s	’s	PART
bam-1791	313	3	disease	disease	PROPN
bam-1791	313	4	(	(	PUNCT
bam-1791	313	5	bd	bd	PROPN
bam-1791	313	6	)	)	PUNCT
bam-1791	313	7	is	be	AUX
bam-1791	313	8	characterized	characterize	VERB
bam-1791	313	9	by	by	ADP
bam-1791	313	10	exercise	exercise	NOUN
bam-1791	313	11	-	-	PUNCT
bam-1791	313	12	induced	induce	VERB
bam-1791	313	13	impairment	impairment	NOUN
bam-1791	313	14	of	of	ADP
bam-1791	313	15	muscle	muscle	NOUN
bam-1791	313	16	relaxation	relaxation	NOUN
bam-1791	313	17	due	due	ADP
bam-1791	313	18	to	to	ADP
bam-1791	313	19	the	the	DET
bam-1791	313	20	lack	lack	NOUN
bam-1791	313	21	of	of	ADP
bam-1791	313	22	the	the	DET
bam-1791	313	23	ca2	ca2	PROPN
bam-1791	313	24	+	+	PROPN
bam-1791	313	25	-pump	-pump	NOUN
bam-1791	313	26	serca1	serca1	NOUN
bam-1791	313	27	from	from	ADP
bam-1791	313	28	the	the	DET
bam-1791	313	29	sarcoplasmic	sarcoplasmic	NOUN
bam-1791	313	30	reticulum	reticulum	NOUN
bam-1791	313	31	membrane	membrane	NOUN
bam-1791	313	32	.	.	PUNCT
bam-1791	314	1	here	here	ADV
bam-1791	314	2	we	we	PRON
bam-1791	314	3	show	show	VERB
bam-1791	314	4	that	that	SCONJ
bam-1791	314	5	serca1	serca1	PROPN
bam-1791	314	6	mutants	mutant	NOUN
bam-1791	314	7	are	be	AUX
bam-1791	314	8	ubiquitinated	ubiquitinated	ADJ
bam-1791	314	9	and	and	CCONJ
bam-1791	314	10	dismantled	dismantle	VERB
bam-1791	314	11	by	by	ADP
bam-1791	314	12	the	the	DET
bam-1791	314	13	proteasome	proteasome	NOUN
bam-1791	314	14	,	,	PUNCT
bam-1791	314	15	suggesting	suggest	VERB
bam-1791	314	16	that	that	SCONJ
bam-1791	314	17	also	also	ADV
bam-1791	314	18	bd	bd	PROPN
bam-1791	314	19	is	be	AUX
bam-1791	314	20	an	an	DET
bam-1791	314	21	upd	upd	NOUN
bam-1791	314	22	.	.	PUNCT
bam-1791	315	1	unfortunately	unfortunately	ADV
bam-1791	315	2	,	,	PUNCT
bam-1791	315	3	to	to	ADP
bam-1791	315	4	date	date	NOUN
bam-1791	315	5	no	no	DET
bam-1791	315	6	effective	effective	ADJ
bam-1791	315	7	therapies	therapy	NOUN
bam-1791	315	8	are	be	AUX
bam-1791	315	9	available	available	ADJ
bam-1791	315	10	to	to	PART
bam-1791	315	11	treat	treat	VERB
bam-1791	315	12	lgmd-2d	lgmd-2d	PUNCT
bam-1791	315	13	or	or	CCONJ
bam-1791	315	14	bd	bd	PROPN
bam-1791	315	15	.	.	PROPN
bam-1791	315	16	therefore	therefore	ADV
bam-1791	315	17	,	,	PUNCT
bam-1791	315	18	a	a	DET
bam-1791	315	19	primary	primary	ADJ
bam-1791	315	20	challenge	challenge	NOUN
bam-1791	315	21	is	be	AUX
bam-1791	315	22	the	the	DET
bam-1791	315	23	identification	identification	NOUN
bam-1791	315	24	of	of	ADP
bam-1791	315	25	potential	potential	ADJ
bam-1791	315	26	pharmacological	pharmacological	ADJ
bam-1791	315	27	targets	target	NOUN
bam-1791	315	28	.	.	PUNCT
bam-1791	316	1	in	in	ADP
bam-1791	316	2	this	this	DET
bam-1791	316	3	perspective	perspective	NOUN
bam-1791	316	4	,	,	PUNCT
bam-1791	316	5	we	we	PRON
bam-1791	316	6	demonstrate	demonstrate	VERB
bam-1791	316	7	that	that	SCONJ
bam-1791	316	8	proteasomal	proteasomal	ADJ
bam-1791	316	9	inhibition	inhibition	NOUN
bam-1791	316	10	rescues	rescue	NOUN
bam-1791	316	11	both	both	CCONJ
bam-1791	316	12	the	the	DET
bam-1791	316	13	expression	expression	NOUN
bam-1791	316	14	and	and	CCONJ
bam-1791	316	15	proper	proper	ADJ
bam-1791	316	16	localization	localization	NOUN
bam-1791	316	17	of	of	ADP
bam-1791	316	18	αsarcoglycan	αsarcoglycan	ADJ
bam-1791	316	19	mutants	mutant	NOUN
bam-1791	316	20	as	as	ADV
bam-1791	316	21	well	well	ADV
bam-1791	316	22	as	as	ADP
bam-1791	316	23	the	the	DET
bam-1791	316	24	expression	expression	NOUN
bam-1791	316	25	of	of	ADP
bam-1791	316	26	mutated	mutate	VERB
bam-1791	316	27	serca1	serca1	NOUN
bam-1791	316	28	and	and	CCONJ
bam-1791	316	29	its	its	PRON
bam-1791	316	30	ca2	ca2	PROPN
bam-1791	316	31	+	+	PROPN
bam-1791	316	32	-pumping	-pumping	ADJ
bam-1791	316	33	activity	activity	NOUN
bam-1791	316	34	.	.	PUNCT
bam-1791	317	1	moreover	moreover	ADV
bam-1791	317	2	,	,	PUNCT
bam-1791	317	3	we	we	PRON
bam-1791	317	4	also	also	ADV
bam-1791	317	5	show	show	VERB
bam-1791	317	6	that	that	SCONJ
bam-1791	317	7	these	these	DET
bam-1791	317	8	mutants	mutant	NOUN
bam-1791	317	9	can	can	AUX
bam-1791	317	10	be	be	AUX
bam-1791	317	11	quantitatively	quantitatively	ADV
bam-1791	317	12	and	and	CCONJ
bam-1791	317	13	qualitatively	qualitatively	ADV
bam-1791	317	14	rescued	rescue	VERB
bam-1791	317	15	by	by	ADP
bam-1791	317	16	using	use	VERB
bam-1791	317	17	small	small	ADJ
bam-1791	317	18	molecules	molecule	NOUN
bam-1791	317	19	that	that	PRON
bam-1791	317	20	force	force	VERB
bam-1791	317	21	protein	protein	NOUN
bam-1791	317	22	folding	folding	NOUN
bam-1791	317	23	.	.	PUNCT
bam-1791	318	1	all	all	ADV
bam-1791	318	2	together	together	ADV
bam-1791	318	3	these	these	DET
bam-1791	318	4	data	datum	NOUN
bam-1791	318	5	open	open	VERB
bam-1791	318	6	the	the	DET
bam-1791	318	7	way	way	NOUN
bam-1791	318	8	to	to	ADP
bam-1791	318	9	new	new	ADJ
bam-1791	318	10	pharmacological	pharmacological	ADJ
bam-1791	318	11	strategies	strategy	NOUN
bam-1791	318	12	,	,	PUNCT
bam-1791	318	13	for	for	ADP
bam-1791	318	14	lgmd-2d	lgmd-2d	PUNCT
bam-1791	318	15	and	and	CCONJ
bam-1791	318	16	bd	bd	PROPN
bam-1791	318	17	,	,	PUNCT
bam-1791	318	18	expected	expect	VERB
bam-1791	318	19	“	"	PUNCT
bam-1791	318	20	to	to	PART
bam-1791	318	21	cure	cure	VERB
bam-1791	318	22	”	"	PUNCT
bam-1791	318	23	the	the	DET
bam-1791	318	24	mutated	mutate	VERB
bam-1791	318	25	proteins	protein	NOUN
bam-1791	318	26	either	either	CCONJ
bam-1791	318	27	by	by	ADP
bam-1791	318	28	promoting	promote	VERB
bam-1791	318	29	their	their	PRON
bam-1791	318	30	folding	folding	NOUN
bam-1791	318	31	or	or	CCONJ
bam-1791	318	32	preventing	prevent	VERB
bam-1791	318	33	their	their	PRON
bam-1791	318	34	disposal	disposal	NOUN
bam-1791	318	35	.	.	PUNCT
bam-1791	319	1	ix	ix	PROPN
bam-1791	319	2	iim	iim	PROPN
bam-1791	319	3	meeting	meeting	NOUN
bam-1791	319	4	,	,	PUNCT
bam-1791	319	5	acaya	acaya	NOUN
bam-1791	319	6	(	(	PUNCT
bam-1791	319	7	lecce	lecce	PROPN
bam-1791	319	8	)	)	PUNCT
bam-1791	319	9	,	,	PUNCT
bam-1791	319	10	october	october	PROPN
bam-1791	319	11	12	12	NUM
bam-1791	319	12	-	-	SYM
bam-1791	319	13	14	14	NUM
bam-1791	319	14	,	,	PUNCT
bam-1791	319	15	2012	2012	NUM
bam-1791	319	16	european	european	PROPN
bam-1791	319	17	journal	journal	PROPN
bam-1791	319	18	translational	translational	ADJ
bam-1791	319	19	myology	myology	NOUN
bam-1791	319	20	basic	basic	ADJ
bam-1791	319	21	applied	apply	VERB
bam-1791	319	22	myology	myology	NOUN
bam-1791	319	23	2012	2012	NUM
bam-1791	319	24	;	;	PUNCT
bam-1791	319	25	22(1&2	22(1&2	NUM
bam-1791	319	26	):	):	PUNCT
bam-1791	319	27	xxx	xxx	NOUN
bam-1791	319	28	-	-	PUNCT
bam-1791	319	29	xxx	xxx	PROPN
bam-1791	319	30	32	32	NUM
bam-1791	319	31	28	28	NUM
bam-1791	319	32	.	.	PUNCT
bam-1791	320	1	characterization	characterization	NOUN
bam-1791	320	2	of	of	ADP
bam-1791	320	3	mechanisms	mechanism	NOUN
bam-1791	320	4	causing	cause	VERB
bam-1791	320	5	the	the	DET
bam-1791	320	6	myopathy	myopathy	NOUN
bam-1791	320	7	associated	associate	VERB
bam-1791	320	8	to	to	ADP
bam-1791	320	9	the	the	DET
bam-1791	320	10	neutral	neutral	ADJ
bam-1791	320	11	lipid	lipid	NOUN
bam-1791	320	12	storage	storage	NOUN
bam-1791	320	13	disease	disease	NOUN
bam-1791	320	14	(	(	PUNCT
bam-1791	320	15	nlsdm	nlsdm	NOUN
bam-1791	320	16	)	)	PUNCT
bam-1791	320	17	.	.	PUNCT
bam-1791	321	1	elisa	elisa	PROPN
bam-1791	321	2	spelta	spelta	PROPN
bam-1791	321	3	,	,	PUNCT
bam-1791	321	4	gabriella	gabriella	PROPN
bam-1791	321	5	dobrowolny	dobrowolny	PROPN
bam-1791	321	6	,	,	PUNCT
bam-1791	321	7	carmine	carmine	PROPN
bam-1791	321	8	nicoletti	nicoletti	NOUN
bam-1791	321	9	,	,	PUNCT
bam-1791	321	10	emanuele	emanuele	PROPN
bam-1791	321	11	rizzuto	rizzuto	PROPN
bam-1791	321	12	,	,	PUNCT
bam-1791	321	13	marcello	marcello	PROPN
bam-1791	321	14	arca	arca	PROPN
bam-1791	321	15	,	,	PUNCT
bam-1791	321	16	antonio	antonio	PROPN
bam-1791	321	17	musarò	musarò	PROPN
bam-1791	321	18	.	.	PUNCT
bam-1791	322	1	sapienza	sapienza	PROPN
bam-1791	322	2	university	university	PROPN
bam-1791	322	3	,	,	PUNCT
bam-1791	322	4	rome	rome	PROPN
bam-1791	322	5	,	,	PUNCT
bam-1791	322	6	italy	italy	PROPN
bam-1791	322	7	,	,	PUNCT
bam-1791	322	8	00161	00161	NUM
bam-1791	322	9	the	the	DET
bam-1791	322	10	neutral	neutral	ADJ
bam-1791	322	11	lipid	lipid	NOUN
bam-1791	322	12	storage	storage	NOUN
bam-1791	322	13	diseases	disease	NOUN
bam-1791	322	14	with	with	ADP
bam-1791	322	15	myopathy	myopathy	ADJ
bam-1791	322	16	(	(	PUNCT
bam-1791	322	17	nlsdm	nlsdm	NOUN
bam-1791	322	18	)	)	PUNCT
bam-1791	322	19	is	be	AUX
bam-1791	322	20	a	a	DET
bam-1791	322	21	newly	newly	ADV
bam-1791	322	22	recognized	recognize	VERB
bam-1791	322	23	disease	disease	NOUN
bam-1791	322	24	caused	cause	VERB
bam-1791	322	25	by	by	ADP
bam-1791	322	26	massive	massive	ADJ
bam-1791	322	27	accumulation	accumulation	NOUN
bam-1791	322	28	of	of	ADP
bam-1791	322	29	triglycerides	triglyceride	NOUN
bam-1791	322	30	in	in	ADP
bam-1791	322	31	the	the	DET
bam-1791	322	32	muscles	muscle	NOUN
bam-1791	322	33	due	due	ADP
bam-1791	322	34	to	to	ADP
bam-1791	322	35	mutations	mutation	NOUN
bam-1791	322	36	in	in	ADP
bam-1791	322	37	the	the	DET
bam-1791	322	38	atgl	atgl	NOUN
bam-1791	322	39	.	.	PUNCT
bam-1791	323	1	the	the	DET
bam-1791	323	2	pathogenic	pathogenic	ADJ
bam-1791	323	3	mechanisms	mechanism	NOUN
bam-1791	323	4	underlying	underlie	VERB
bam-1791	323	5	muscle	muscle	NOUN
bam-1791	323	6	damage	damage	NOUN
bam-1791	323	7	in	in	ADP
bam-1791	323	8	nlsdm	nlsdm	NOUN
bam-1791	323	9	is	be	AUX
bam-1791	323	10	completely	completely	ADV
bam-1791	323	11	unknown	unknown	ADJ
bam-1791	323	12	.	.	PUNCT
bam-1791	324	1	taking	take	VERB
bam-1791	324	2	advantage	advantage	NOUN
bam-1791	324	3	of	of	ADP
bam-1791	324	4	atgl	atgl	ADJ
bam-1791	324	5	knockout	knockout	NOUN
bam-1791	324	6	(	(	PUNCT
bam-1791	324	7	atgl-/-	atgl-/-	NOUN
bam-1791	324	8	)	)	PUNCT
bam-1791	324	9	mouse	mouse	NOUN
bam-1791	324	10	model	model	NOUN
bam-1791	324	11	(	(	PUNCT
bam-1791	324	12	kindly	kindly	ADV
bam-1791	324	13	provided	provide	VERB
bam-1791	324	14	by	by	ADP
bam-1791	324	15	dr	dr	PROPN
bam-1791	324	16	.	.	PROPN
bam-1791	324	17	zechner	zechner	PROPN
bam-1791	324	18	)	)	PUNCT
bam-1791	324	19	we	we	PRON
bam-1791	324	20	have	have	AUX
bam-1791	324	21	investigated	investigate	VERB
bam-1791	324	22	at	at	ADP
bam-1791	324	23	histological	histological	ADJ
bam-1791	324	24	,	,	PUNCT
bam-1791	324	25	functional	functional	ADJ
bam-1791	324	26	,	,	PUNCT
bam-1791	324	27	and	and	CCONJ
bam-1791	324	28	molecular	molecular	ADJ
bam-1791	324	29	level	level	NOUN
bam-1791	324	30	the	the	DET
bam-1791	324	31	potential	potential	ADJ
bam-1791	324	32	pathogenic	pathogenic	ADJ
bam-1791	324	33	events	event	NOUN
bam-1791	324	34	associated	associate	VERB
bam-1791	324	35	with	with	ADP
bam-1791	324	36	nlsdm	nlsdm	NOUN
bam-1791	324	37	.	.	PUNCT
bam-1791	325	1	histological	histological	ADJ
bam-1791	325	2	analysis	analysis	NOUN
bam-1791	325	3	,	,	PUNCT
bam-1791	325	4	performed	perform	VERB
bam-1791	325	5	on	on	ADP
bam-1791	325	6	different	different	ADJ
bam-1791	325	7	muscle	muscle	NOUN
bam-1791	325	8	types	type	NOUN
bam-1791	325	9	(	(	PUNCT
bam-1791	325	10	tibialis	tibialis	NOUN
bam-1791	325	11	anterior	anterior	ADJ
bam-1791	325	12	,	,	PUNCT
bam-1791	325	13	soleus	soleus	PROPN
bam-1791	325	14	,	,	PUNCT
bam-1791	325	15	edl	edl	PROPN
bam-1791	325	16	,	,	PUNCT
bam-1791	325	17	diaphragm	diaphragm	PROPN
bam-1791	325	18	)	)	PUNCT
bam-1791	325	19	of	of	ADP
bam-1791	325	20	2.5	2.5	NUM
bam-1791	325	21	months	month	NOUN
bam-1791	325	22	old	old	ADJ
bam-1791	325	23	mice	mouse	NOUN
bam-1791	325	24	,	,	PUNCT
bam-1791	325	25	revealed	reveal	VERB
bam-1791	325	26	a	a	DET
bam-1791	325	27	reduction	reduction	NOUN
bam-1791	325	28	in	in	ADP
bam-1791	325	29	the	the	DET
bam-1791	325	30	cross	cross	NOUN
bam-1791	325	31	sectional	sectional	ADJ
bam-1791	325	32	area	area	NOUN
bam-1791	325	33	of	of	ADP
bam-1791	325	34	the	the	DET
bam-1791	325	35	single	single	ADJ
bam-1791	325	36	myofibres	myofibre	NOUN
bam-1791	325	37	in	in	ADP
bam-1791	325	38	atgl-/edl	atgl-/edl	PROPN
bam-1791	325	39	and	and	CCONJ
bam-1791	325	40	tibialis	tibialis	PROPN
bam-1791	325	41	anterior	anterior	ADJ
bam-1791	325	42	muscle	muscle	NOUN
bam-1791	325	43	,	,	PUNCT
bam-1791	325	44	compared	compare	VERB
bam-1791	325	45	to	to	ADP
bam-1791	325	46	wt	wt	PROPN
bam-1791	325	47	.	.	PUNCT
bam-1791	326	1	this	this	PRON
bam-1791	326	2	was	be	AUX
bam-1791	326	3	associated	associate	VERB
bam-1791	326	4	with	with	ADP
bam-1791	326	5	the	the	DET
bam-1791	326	6	presence	presence	NOUN
bam-1791	326	7	of	of	ADP
bam-1791	326	8	several	several	ADJ
bam-1791	326	9	myofibres	myofibre	NOUN
bam-1791	326	10	with	with	ADP
bam-1791	326	11	central	central	ADJ
bam-1791	326	12	nuclei	nucleus	NOUN
bam-1791	326	13	,	,	PUNCT
bam-1791	326	14	indicating	indicate	VERB
bam-1791	326	15	either	either	CCONJ
bam-1791	326	16	the	the	DET
bam-1791	326	17	activation	activation	NOUN
bam-1791	326	18	of	of	ADP
bam-1791	326	19	a	a	DET
bam-1791	326	20	compensatory	compensatory	NOUN
bam-1791	326	21	,	,	PUNCT
bam-1791	326	22	but	but	CCONJ
bam-1791	326	23	defective	defective	ADJ
bam-1791	326	24	,	,	PUNCT
bam-1791	326	25	regenerative	regenerative	ADJ
bam-1791	326	26	mechanism	mechanism	NOUN
bam-1791	326	27	or	or	CCONJ
bam-1791	326	28	alteration	alteration	NOUN
bam-1791	326	29	in	in	ADP
bam-1791	326	30	the	the	DET
bam-1791	326	31	maturation	maturation	NOUN
bam-1791	326	32	process	process	NOUN
bam-1791	326	33	.	.	PUNCT
bam-1791	327	1	to	to	PART
bam-1791	327	2	further	far	ADV
bam-1791	327	3	address	address	VERB
bam-1791	327	4	this	this	DET
bam-1791	327	5	point	point	NOUN
bam-1791	327	6	,	,	PUNCT
bam-1791	327	7	we	we	PRON
bam-1791	327	8	have	have	AUX
bam-1791	327	9	analyzed	analyze	VERB
bam-1791	327	10	the	the	DET
bam-1791	327	11	expression	expression	NOUN
bam-1791	327	12	markers	marker	NOUN
bam-1791	327	13	of	of	ADP
bam-1791	327	14	the	the	DET
bam-1791	327	15	myogenic	myogenic	ADJ
bam-1791	327	16	program	program	NOUN
bam-1791	327	17	such	such	ADJ
bam-1791	327	18	as	as	ADP
bam-1791	327	19	desmin	desmin	ADJ
bam-1791	327	20	(	(	PUNCT
bam-1791	327	21	proliferation	proliferation	NOUN
bam-1791	327	22	)	)	PUNCT
bam-1791	327	23	and	and	CCONJ
bam-1791	327	24	myogenin	myogenin	ADJ
bam-1791	327	25	(	(	PUNCT
bam-1791	327	26	commitment	commitment	NOUN
bam-1791	327	27	)	)	PUNCT
bam-1791	327	28	,	,	PUNCT
bam-1791	327	29	which	which	DET
bam-1791	327	30	expression	expression	NOUN
bam-1791	327	31	normally	normally	ADV
bam-1791	327	32	decrease	decrease	VERB
bam-1791	327	33	at	at	ADP
bam-1791	327	34	the	the	DET
bam-1791	327	35	stage	stage	NOUN
bam-1791	327	36	of	of	ADP
bam-1791	327	37	mature	mature	ADJ
bam-1791	327	38	muscle	muscle	NOUN
bam-1791	327	39	.	.	PUNCT
bam-1791	328	1	rtqpcr	rtqpcr	ADJ
bam-1791	328	2	and	and	CCONJ
bam-1791	328	3	western	western	ADJ
bam-1791	328	4	blot	blot	NOUN
bam-1791	328	5	analysis	analysis	NOUN
bam-1791	328	6	revealed	reveal	VERB
bam-1791	328	7	a	a	DET
bam-1791	328	8	significant	significant	ADJ
bam-1791	328	9	increase	increase	NOUN
bam-1791	328	10	in	in	ADP
bam-1791	328	11	gene	gene	NOUN
bam-1791	328	12	and	and	CCONJ
bam-1791	328	13	protein	protein	NOUN
bam-1791	328	14	expression	expression	NOUN
bam-1791	328	15	of	of	ADP
bam-1791	328	16	both	both	CCONJ
bam-1791	328	17	desmin	desmin	ADJ
bam-1791	328	18	and	and	CCONJ
bam-1791	328	19	myogenin	myogenin	ADJ
bam-1791	328	20	in	in	ADP
bam-1791	328	21	atgl-/diaphragm	atgl-/diaphragm	X
bam-1791	328	22	muscle	muscle	NOUN
bam-1791	328	23	compared	compare	VERB
bam-1791	328	24	to	to	ADP
bam-1791	328	25	wt	wt	PROPN
bam-1791	328	26	.	.	PUNCT
bam-1791	329	1	moreover	moreover	ADV
bam-1791	329	2	we	we	PRON
bam-1791	329	3	have	have	AUX
bam-1791	329	4	analyzed	analyze	VERB
bam-1791	329	5	,	,	PUNCT
bam-1791	329	6	by	by	ADP
bam-1791	329	7	rtqpcr	rtqpcr	ADJ
bam-1791	329	8	,	,	PUNCT
bam-1791	329	9	the	the	DET
bam-1791	329	10	expression	expression	NOUN
bam-1791	329	11	of	of	ADP
bam-1791	329	12	the	the	DET
bam-1791	329	13	subunit	subunit	NOUN
bam-1791	329	14	gamma	gamma	NOUN
bam-1791	329	15	of	of	ADP
bam-1791	329	16	acetylcholine	acetylcholine	ADJ
bam-1791	329	17	receptor	receptor	NOUN
bam-1791	329	18	that	that	PRON
bam-1791	329	19	is	be	AUX
bam-1791	329	20	undetectable	undetectable	ADJ
bam-1791	329	21	or	or	CCONJ
bam-1791	329	22	low	low	ADJ
bam-1791	329	23	in	in	ADP
bam-1791	329	24	innervated	innervated	ADJ
bam-1791	329	25	adult	adult	NOUN
bam-1791	329	26	active	active	ADJ
bam-1791	329	27	muscle	muscle	NOUN
bam-1791	329	28	.	.	PUNCT
bam-1791	330	1	we	we	PRON
bam-1791	330	2	noted	note	VERB
bam-1791	330	3	an	an	DET
bam-1791	330	4	up	up	ADJ
bam-1791	330	5	regulation	regulation	NOUN
bam-1791	330	6	of	of	ADP
bam-1791	330	7	the	the	DET
bam-1791	330	8	expression	expression	NOUN
bam-1791	330	9	of	of	ADP
bam-1791	330	10	this	this	DET
bam-1791	330	11	subunit	subunit	NOUN
bam-1791	330	12	in	in	ADP
bam-1791	330	13	atgl	atgl	ADJ
bam-1791	330	14	-/	-/	PUNCT
bam-1791	330	15	diaphragm	diaphragm	NOUN
bam-1791	330	16	muscle	muscle	NOUN
bam-1791	330	17	compared	compare	VERB
bam-1791	330	18	to	to	ADP
bam-1791	330	19	wt	wt	PROPN
bam-1791	330	20	,	,	PUNCT
bam-1791	330	21	indicating	indicate	VERB
bam-1791	330	22	probably	probably	ADV
bam-1791	330	23	an	an	DET
bam-1791	330	24	alteration	alteration	NOUN
bam-1791	330	25	of	of	ADP
bam-1791	330	26	the	the	DET
bam-1791	330	27	neuromuscular	neuromuscular	ADJ
bam-1791	330	28	junction	junction	NOUN
bam-1791	330	29	.	.	PUNCT
bam-1791	331	1	functional	functional	ADJ
bam-1791	331	2	analysis	analysis	NOUN
bam-1791	331	3	revealed	reveal	VERB
bam-1791	331	4	a	a	DET
bam-1791	331	5	decrease	decrease	NOUN
bam-1791	331	6	in	in	ADP
bam-1791	331	7	the	the	DET
bam-1791	331	8	specific	specific	ADJ
bam-1791	331	9	and	and	CCONJ
bam-1791	331	10	maximum	maximum	ADJ
bam-1791	331	11	force	force	NOUN
bam-1791	331	12	of	of	ADP
bam-1791	331	13	edl	edl	PROPN
bam-1791	331	14	muscle	muscle	NOUN
bam-1791	331	15	of	of	ADP
bam-1791	331	16	atgl-/mice	atgl-/mice	NUM
bam-1791	331	17	compared	compare	VERB
bam-1791	331	18	to	to	ADP
bam-1791	331	19	wt	wt	PROPN
bam-1791	331	20	;	;	PUNCT
bam-1791	331	21	instead	instead	ADV
bam-1791	331	22	we	we	PRON
bam-1791	331	23	have	have	AUX
bam-1791	331	24	not	not	PART
bam-1791	331	25	noted	note	VERB
bam-1791	331	26	difference	difference	NOUN
bam-1791	331	27	both	both	CCONJ
bam-1791	331	28	in	in	ADP
bam-1791	331	29	the	the	DET
bam-1791	331	30	specific	specific	ADJ
bam-1791	331	31	and	and	CCONJ
bam-1791	331	32	maximum	maximum	ADJ
bam-1791	331	33	force	force	NOUN
bam-1791	331	34	in	in	ADP
bam-1791	331	35	soleus	soleus	ADJ
bam-1791	331	36	muscle	muscle	NOUN
bam-1791	331	37	.	.	PUNCT
bam-1791	332	1	this	this	DET
bam-1791	332	2	observation	observation	NOUN
bam-1791	332	3	correlates	correlate	VERB
bam-1791	332	4	with	with	ADP
bam-1791	332	5	the	the	DET
bam-1791	332	6	histological	histological	ADJ
bam-1791	332	7	analysis	analysis	NOUN
bam-1791	332	8	.	.	PUNCT
bam-1791	333	1	29	29	NUM
bam-1791	333	2	.	.	PUNCT
bam-1791	333	3	characterization	characterization	NOUN
bam-1791	333	4	of	of	ADP
bam-1791	333	5	hclc-1	hclc-1	NUM
bam-1791	333	6	chloride	chloride	NOUN
bam-1791	333	7	channel	channel	NOUN
bam-1791	333	8	mutations	mutation	NOUN
bam-1791	333	9	associated	associate	VERB
bam-1791	333	10	with	with	ADP
bam-1791	333	11	myotonia	myotonia	NOUN
bam-1791	333	12	congenita	congenita	PROPN
bam-1791	333	13	jean	jean	PROPN
bam-1791	333	14	-	-	PUNCT
bam-1791	333	15	françois	françois	PROPN
bam-1791	333	16	desaphy,1	desaphy,1	NOUN
bam-1791	333	17	gianluca	gianluca	PROPN
bam-1791	333	18	gramegna,1	gramegna,1	PROPN
bam-1791	333	19	maria	maria	PROPN
bam-1791	333	20	maddalena	maddalena	PROPN
bam-1791	333	21	dinardo,1	dinardo,1	PROPN
bam-1791	333	22	concetta	concetta	PROPN
bam-1791	333	23	altamura,1	altamura,1	NOUN
bam-1791	333	24	anna	anna	PROPN
bam-1791	333	25	modoni,2	modoni,2	PROPN
bam-1791	333	26	mauro	mauro	PROPN
bam-1791	333	27	lomonaco,2	lomonaco,2	PROPN
bam-1791	333	28	diana	diana	PROPN
bam-1791	333	29	conte	conte	PROPN
bam-1791	333	30	camerino1	camerino1	PROPN
bam-1791	334	1	1pharmacology	1pharmacology	NUM
bam-1791	334	2	section	section	NOUN
bam-1791	334	3	,	,	PUNCT
bam-1791	334	4	dept	dept	NOUN
bam-1791	334	5	.	.	PROPN
bam-1791	334	6	pharmacy	pharmacy	PROPN
bam-1791	334	7	,	,	PUNCT
bam-1791	334	8	university	university	NOUN
bam-1791	334	9	of	of	ADP
bam-1791	334	10	bari	bari	NOUN
bam-1791	334	11	,	,	PUNCT
bam-1791	334	12	italy	italy	PROPN
bam-1791	334	13	2dept	2dept	NUM
bam-1791	334	14	.	.	PUNCT
bam-1791	334	15	neuroscience	neuroscience	PROPN
bam-1791	334	16	,	,	PUNCT
bam-1791	334	17	catholic	catholic	PROPN
bam-1791	334	18	university	university	PROPN
bam-1791	334	19	,	,	PUNCT
bam-1791	334	20	rome	rome	PROPN
bam-1791	334	21	,	,	PUNCT
bam-1791	334	22	italy	italy	PROPN
bam-1791	334	23	myotonia	myotonia	PROPN
bam-1791	334	24	congenita	congenita	PROPN
bam-1791	334	25	(	(	PUNCT
bam-1791	334	26	mc	mc	PROPN
bam-1791	334	27	)	)	PUNCT
bam-1791	334	28	is	be	AUX
bam-1791	334	29	an	an	DET
bam-1791	334	30	inherited	inherit	VERB
bam-1791	334	31	muscle	muscle	NOUN
bam-1791	334	32	disease	disease	NOUN
bam-1791	334	33	characterized	characterize	VERB
bam-1791	334	34	by	by	ADP
bam-1791	334	35	muscle	muscle	NOUN
bam-1791	334	36	stiffness	stiffness	NOUN
bam-1791	334	37	during	during	ADP
bam-1791	334	38	forceful	forceful	ADJ
bam-1791	334	39	movement	movement	NOUN
bam-1791	334	40	,	,	PUNCT
bam-1791	334	41	due	due	ADP
bam-1791	334	42	to	to	ADP
bam-1791	334	43	sarcolemma	sarcolemma	ADJ
bam-1791	334	44	electrical	electrical	ADJ
bam-1791	334	45	instability	instability	NOUN
bam-1791	334	46	.	.	PUNCT
bam-1791	335	1	mc	mc	PROPN
bam-1791	335	2	stems	stem	VERB
bam-1791	335	3	from	from	ADP
bam-1791	335	4	loss	loss	NOUN
bam-1791	335	5	-	-	PUNCT
bam-1791	335	6	of	of	ADP
bam-1791	335	7	-	-	PUNCT
bam-1791	335	8	function	function	NOUN
bam-1791	335	9	mutations	mutation	NOUN
bam-1791	335	10	in	in	ADP
bam-1791	335	11	the	the	DET
bam-1791	335	12	clc-1	clc-1	PUNCT
bam-1791	335	13	chloride	chloride	NOUN
bam-1791	335	14	channel	channel	NOUN
bam-1791	335	15	gene	gene	NOUN
bam-1791	335	16	.	.	PUNCT
bam-1791	336	1	three	three	NUM
bam-1791	336	2	clc-1	clc-1	PRON
bam-1791	336	3	mutations	mutation	NOUN
bam-1791	336	4	(	(	PUNCT
bam-1791	336	5	g190s	g190s	PROPN
bam-1791	336	6	,	,	PUNCT
bam-1791	336	7	a531v	a531v	PROPN
bam-1791	336	8	and	and	CCONJ
bam-1791	336	9	f167l	f167l	PROPN
bam-1791	336	10	)	)	PUNCT
bam-1791	336	11	individuated	individuate	VERB
bam-1791	336	12	in	in	ADP
bam-1791	336	13	mc	mc	PROPN
bam-1791	336	14	patients	patient	NOUN
bam-1791	336	15	were	be	AUX
bam-1791	336	16	introduced	introduce	VERB
bam-1791	336	17	in	in	ADP
bam-1791	336	18	recombinant	recombinant	ADJ
bam-1791	336	19	hclc-1	hclc-1	NOUN
bam-1791	336	20	and	and	CCONJ
bam-1791	336	21	functionally	functionally	ADV
bam-1791	336	22	characterized	characterize	VERB
bam-1791	336	23	in	in	ADP
bam-1791	336	24	hek	hek	PROPN
bam-1791	336	25	cells	cell	NOUN
bam-1791	336	26	using	use	VERB
bam-1791	336	27	whole	whole	ADJ
bam-1791	336	28	-	-	PUNCT
bam-1791	336	29	cell	cell	NOUN
bam-1791	336	30	patch	patch	NOUN
bam-1791	336	31	-	-	PUNCT
bam-1791	336	32	clamp	clamp	NOUN
bam-1791	336	33	.	.	PUNCT
bam-1791	337	1	a531v	a531v	NOUN
bam-1791	337	2	greatly	greatly	ADV
bam-1791	337	3	decreased	decrease	VERB
bam-1791	337	4	chloride	chloride	NOUN
bam-1791	337	5	current	current	ADJ
bam-1791	337	6	density	density	NOUN
bam-1791	337	7	but	but	CCONJ
bam-1791	337	8	the	the	DET
bam-1791	337	9	open	open	ADJ
bam-1791	337	10	probability	probability	NOUN
bam-1791	337	11	voltage	voltage	NOUN
bam-1791	337	12	-	-	PUNCT
bam-1791	337	13	dependence	dependence	NOUN
bam-1791	337	14	(	(	PUNCT
bam-1791	337	15	po	po	NOUN
bam-1791	337	16	)	)	PUNCT
bam-1791	337	17	and	and	CCONJ
bam-1791	337	18	deactivation	deactivation	NOUN
bam-1791	337	19	kinetics	kinetic	NOUN
bam-1791	337	20	were	be	AUX
bam-1791	337	21	similar	similar	ADJ
bam-1791	337	22	to	to	ADP
bam-1791	337	23	wt	wt	PROPN
bam-1791	337	24	.	.	PUNCT
bam-1791	338	1	instead	instead	ADV
bam-1791	338	2	,	,	PUNCT
bam-1791	338	3	g190s	g190s	PROPN
bam-1791	338	4	determined	determine	VERB
bam-1791	338	5	a	a	DET
bam-1791	338	6	remarkable	remarkable	ADJ
bam-1791	338	7	positive	positive	ADJ
bam-1791	338	8	shift	shift	NOUN
bam-1791	338	9	of	of	ADP
bam-1791	338	10	po	po	NOUN
bam-1791	338	11	.	.	PUNCT
bam-1791	339	1	although	although	SCONJ
bam-1791	339	2	the	the	DET
bam-1791	339	3	underlying	underlying	ADJ
bam-1791	339	4	mechanisms	mechanism	NOUN
bam-1791	339	5	were	be	AUX
bam-1791	339	6	different	different	ADJ
bam-1791	339	7	,	,	PUNCT
bam-1791	339	8	the	the	DET
bam-1791	339	9	dramatic	dramatic	ADJ
bam-1791	339	10	reduction	reduction	NOUN
bam-1791	339	11	of	of	ADP
bam-1791	339	12	a531v	a531v	PROPN
bam-1791	339	13	and	and	CCONJ
bam-1791	339	14	g190s	g190s	PROPN
bam-1791	339	15	chloride	chloride	NOUN
bam-1791	339	16	currents	current	NOUN
bam-1791	339	17	fully	fully	ADV
bam-1791	339	18	explain	explain	VERB
bam-1791	339	19	their	their	PRON
bam-1791	339	20	role	role	NOUN
bam-1791	339	21	in	in	ADP
bam-1791	339	22	determining	determine	VERB
bam-1791	339	23	mc	mc	PROPN
bam-1791	339	24	.	.	PUNCT
bam-1791	340	1	conversely	conversely	ADV
bam-1791	340	2	,	,	PUNCT
bam-1791	340	3	f167l	f167l	PROPN
bam-1791	340	4	did	do	AUX
bam-1791	340	5	not	not	PART
bam-1791	340	6	affect	affect	VERB
bam-1791	340	7	chloride	chloride	ADJ
bam-1791	340	8	current	current	ADJ
bam-1791	340	9	density	density	NOUN
bam-1791	340	10	,	,	PUNCT
bam-1791	340	11	kinetics	kinetic	NOUN
bam-1791	340	12	,	,	PUNCT
bam-1791	340	13	and	and	CCONJ
bam-1791	340	14	voltage	voltage	NOUN
bam-1791	340	15	dependence	dependence	NOUN
bam-1791	340	16	.	.	PUNCT
bam-1791	341	1	we	we	PRON
bam-1791	341	2	thus	thus	ADV
bam-1791	341	3	characterized	characterize	VERB
bam-1791	341	4	the	the	DET
bam-1791	341	5	compound	compound	NOUN
bam-1791	341	6	mutations	mutation	NOUN
bam-1791	341	7	found	find	VERB
bam-1791	341	8	in	in	ADP
bam-1791	341	9	patients	patient	NOUN
bam-1791	341	10	carrying	carry	VERB
bam-1791	341	11	f167l	f167l	PROPN
bam-1791	341	12	,	,	PUNCT
bam-1791	341	13	namely	namely	ADV
bam-1791	341	14	g355r	g355r	ADJ
bam-1791	341	15	,	,	PUNCT
bam-1791	341	16	g284r	g284r	PROPN
bam-1791	341	17	,	,	PUNCT
bam-1791	341	18	y686x	y686x	PROPN
bam-1791	341	19	,	,	PUNCT
bam-1791	341	20	p558s	p558s	PROPN
bam-1791	341	21	and	and	CCONJ
bam-1791	341	22	r105c	r105c	PROPN
bam-1791	341	23	.	.	PUNCT
bam-1791	342	1	the	the	DET
bam-1791	342	2	g284r	g284r	PROPN
bam-1791	342	3	,	,	PUNCT
bam-1791	342	4	g355r	g355r	ADJ
bam-1791	342	5	and	and	CCONJ
bam-1791	342	6	y686x	y686x	ADJ
bam-1791	342	7	mutations	mutation	NOUN
bam-1791	342	8	did	do	AUX
bam-1791	342	9	not	not	PART
bam-1791	342	10	generate	generate	VERB
bam-1791	342	11	any	any	DET
bam-1791	342	12	chloride	chloride	NOUN
bam-1791	342	13	current	current	NOUN
bam-1791	342	14	,	,	PUNCT
bam-1791	342	15	suggesting	suggest	VERB
bam-1791	342	16	that	that	SCONJ
bam-1791	342	17	they	they	PRON
bam-1791	342	18	constitute	constitute	VERB
bam-1791	342	19	the	the	DET
bam-1791	342	20	main	main	ADJ
bam-1791	342	21	contributor	contributor	NOUN
bam-1791	342	22	to	to	PART
bam-1791	342	23	myotonia	myotonia	NOUN
bam-1791	342	24	in	in	ADP
bam-1791	342	25	heterozygous	heterozygous	ADJ
bam-1791	342	26	patients	patient	NOUN
bam-1791	342	27	.	.	PUNCT
bam-1791	343	1	whereas	whereas	SCONJ
bam-1791	343	2	r105c	r105c	PROPN
bam-1791	343	3	currents	current	NOUN
bam-1791	343	4	were	be	AUX
bam-1791	343	5	very	very	ADV
bam-1791	343	6	similar	similar	ADJ
bam-1791	343	7	to	to	ADP
bam-1791	343	8	wt	wt	NUM
bam-1791	343	9	,	,	PUNCT
bam-1791	343	10	p558s	p558s	PROPN
bam-1791	343	11	profoundly	profoundly	ADV
bam-1791	343	12	affected	affect	VERB
bam-1791	343	13	current	current	ADJ
bam-1791	343	14	kinetics	kinetic	NOUN
bam-1791	343	15	and	and	CCONJ
bam-1791	343	16	voltage	voltage	NOUN
bam-1791	343	17	dependence	dependence	NOUN
bam-1791	343	18	.	.	PUNCT
bam-1791	344	1	nevertheless	nevertheless	ADV
bam-1791	344	2	,	,	PUNCT
bam-1791	344	3	both	both	DET
bam-1791	344	4	mutations	mutation	NOUN
bam-1791	344	5	reduced	reduce	VERB
bam-1791	344	6	chloride	chloride	NOUN
bam-1791	344	7	current	current	ADJ
bam-1791	344	8	density	density	NOUN
bam-1791	344	9	,	,	PUNCT
bam-1791	344	10	confirming	confirm	VERB
bam-1791	344	11	their	their	PRON
bam-1791	344	12	guilty	guilty	ADJ
bam-1791	344	13	role	role	NOUN
bam-1791	344	14	in	in	ADP
bam-1791	344	15	mc	mc	PROPN
bam-1791	344	16	.	.	PUNCT
bam-1791	345	1	co	co	NOUN
bam-1791	345	2	-	-	NOUN
bam-1791	345	3	expression	expression	ADJ
bam-1791	345	4	experiments	experiment	NOUN
bam-1791	345	5	would	would	AUX
bam-1791	345	6	allow	allow	VERB
bam-1791	345	7	to	to	PART
bam-1791	345	8	study	study	VERB
bam-1791	345	9	the	the	DET
bam-1791	345	10	interaction	interaction	NOUN
bam-1791	345	11	between	between	ADP
bam-1791	345	12	compound	compound	NOUN
bam-1791	345	13	mutations	mutation	NOUN
bam-1791	345	14	.	.	PUNCT
bam-1791	346	1	supported	support	VERB
bam-1791	346	2	by	by	ADP
bam-1791	346	3	telethon	telethon	PROPN
bam-1791	346	4	-	-	PUNCT
bam-1791	346	5	italy	italy	PROPN
bam-1791	346	6	(	(	PUNCT
bam-1791	346	7	grant	grant	PROPN
bam-1791	346	8	ggp10101	ggp10101	NOUN
bam-1791	346	9	)	)	PUNCT
bam-1791	346	10	and	and	CCONJ
bam-1791	346	11	afm	afm	PROPN
bam-1791	346	12	-	-	PROPN
bam-1791	346	13	france	france	PROPN
bam-1791	346	14	(	(	PUNCT
bam-1791	346	15	grant	grant	PROPN
bam-1791	346	16	15020	15020	NUM
bam-1791	346	17	)	)	PUNCT
bam-1791	346	18	.	.	PUNCT
bam-1791	347	1	30	30	NUM
bam-1791	347	2	.	.	PUNCT
bam-1791	348	1	in	in	ADP
bam-1791	348	2	vitro	vitro	X
bam-1791	348	3	analysis	analysis	NOUN
bam-1791	348	4	of	of	ADP
bam-1791	348	5	diaphragm	diaphragm	PROPN
bam-1791	348	6	neurojunction	neurojunction	NOUN
bam-1791	348	7	functionality	functionality	NOUN
bam-1791	348	8	emanuele	emanuele	PROPN
bam-1791	348	9	rizzuto1,3	rizzuto1,3	PROPN
bam-1791	348	10	,	,	PUNCT
bam-1791	348	11	zaccaria	zaccaria	PROPN
bam-1791	348	12	del	del	PROPN
bam-1791	348	13	prete1	prete1	PROPN
bam-1791	348	14	,	,	PUNCT
bam-1791	348	15	antonio	antonio	PROPN
bam-1791	348	16	musarò2,3	musarò2,3	PROPN
bam-1791	348	17	1	1	NUM
bam-1791	348	18	department	department	NOUN
bam-1791	348	19	of	of	ADP
bam-1791	348	20	mechanical	mechanical	ADJ
bam-1791	348	21	and	and	CCONJ
bam-1791	348	22	aerospace	aerospace	NOUN
bam-1791	348	23	engineering	engineering	NOUN
bam-1791	348	24	,	,	PUNCT
bam-1791	348	25	sapienza	sapienza	PROPN
bam-1791	348	26	university	university	PROPN
bam-1791	348	27	of	of	ADP
bam-1791	348	28	rome	rome	PROPN
bam-1791	348	29	,	,	PUNCT
bam-1791	348	30	italy	italy	PROPN
bam-1791	348	31	2	2	NUM
bam-1791	348	32	institute	institute	PROPN
bam-1791	348	33	pasteur	pasteur	PROPN
bam-1791	348	34	cencibolognetti	cencibolognetti	PROPN
bam-1791	348	35	,	,	PUNCT
bam-1791	348	36	dahfmo	dahfmo	NOUN
bam-1791	348	37	-	-	PUNCT
bam-1791	348	38	unit	unit	NOUN
bam-1791	348	39	of	of	ADP
bam-1791	348	40	histology	histology	NOUN
bam-1791	348	41	and	and	CCONJ
bam-1791	348	42	medical	medical	ADJ
bam-1791	348	43	embryology	embryology	NOUN
bam-1791	348	44	3	3	NUM
bam-1791	348	45	iim	iim	PROPN
bam-1791	348	46	,	,	PUNCT
bam-1791	348	47	sapienza	sapienza	PROPN
bam-1791	348	48	university	university	PROPN
bam-1791	348	49	of	of	ADP
bam-1791	348	50	rome	rome	PROPN
bam-1791	348	51	,	,	PUNCT
bam-1791	348	52	italy	italy	PROPN
bam-1791	348	53	ix	ix	PROPN
bam-1791	348	54	iim	iim	PROPN
bam-1791	348	55	meeting	meeting	NOUN
bam-1791	348	56	,	,	PUNCT
bam-1791	348	57	acaya	acaya	NOUN
bam-1791	348	58	(	(	PUNCT
bam-1791	348	59	lecce	lecce	PROPN
bam-1791	348	60	)	)	PUNCT
bam-1791	348	61	,	,	PUNCT
bam-1791	348	62	october	october	PROPN
bam-1791	348	63	12	12	NUM
bam-1791	348	64	-	-	SYM
bam-1791	348	65	14	14	NUM
bam-1791	348	66	,	,	PUNCT
bam-1791	348	67	2012	2012	NUM
bam-1791	348	68	european	european	PROPN
bam-1791	348	69	journal	journal	PROPN
bam-1791	348	70	translational	translational	ADJ
bam-1791	348	71	myology	myology	NOUN
bam-1791	348	72	basic	basic	ADJ
bam-1791	348	73	applied	apply	VERB
bam-1791	348	74	myology	myology	NOUN
bam-1791	348	75	2012	2012	NUM
bam-1791	348	76	;	;	PUNCT
bam-1791	348	77	22(1&2	22(1&2	NUM
bam-1791	348	78	):	):	PUNCT
bam-1791	348	79	xxx	xxx	NOUN
bam-1791	348	80	-	-	PUNCT
bam-1791	348	81	xxx	xxx	NOUN
bam-1791	348	82	33	33	NUM
bam-1791	348	83	in	in	ADP
bam-1791	348	84	the	the	DET
bam-1791	348	85	last	last	ADJ
bam-1791	348	86	years	year	NOUN
bam-1791	348	87	,	,	PUNCT
bam-1791	348	88	new	new	ADJ
bam-1791	348	89	studies	study	NOUN
bam-1791	348	90	showed	show	VERB
bam-1791	348	91	the	the	DET
bam-1791	348	92	relevance	relevance	NOUN
bam-1791	348	93	of	of	ADP
bam-1791	348	94	skeletal	skeletal	ADJ
bam-1791	348	95	muscle	muscle	NOUN
bam-1791	348	96	within	within	ADP
bam-1791	348	97	the	the	DET
bam-1791	348	98	pathogenesis	pathogenesis	NOUN
bam-1791	348	99	of	of	ADP
bam-1791	348	100	the	the	DET
bam-1791	348	101	als	als	NOUN
bam-1791	348	102	[	[	X
bam-1791	348	103	1	1	NUM
bam-1791	348	104	]	]	PUNCT
bam-1791	348	105	,	,	PUNCT
bam-1791	348	106	giving	give	VERB
bam-1791	348	107	to	to	ADP
bam-1791	348	108	the	the	DET
bam-1791	348	109	neuromuscular	neuromuscular	ADJ
bam-1791	348	110	junction	junction	NOUN
bam-1791	348	111	(	(	PUNCT
bam-1791	348	112	nmj	nmj	NOUN
bam-1791	348	113	)	)	PUNCT
bam-1791	348	114	a	a	DET
bam-1791	348	115	pivotal	pivotal	ADJ
bam-1791	348	116	role	role	NOUN
bam-1791	348	117	in	in	ADP
bam-1791	348	118	the	the	DET
bam-1791	348	119	communication	communication	NOUN
bam-1791	348	120	between	between	ADP
bam-1791	348	121	muscle	muscle	NOUN
bam-1791	348	122	and	and	CCONJ
bam-1791	348	123	nerve	nerve	NOUN
bam-1791	348	124	.	.	PUNCT
bam-1791	349	1	within	within	ADP
bam-1791	349	2	this	this	DET
bam-1791	349	3	contest	contest	NOUN
bam-1791	349	4	,	,	PUNCT
bam-1791	349	5	we	we	PRON
bam-1791	349	6	developed	develop	VERB
bam-1791	349	7	an	an	DET
bam-1791	349	8	experimental	experimental	ADJ
bam-1791	349	9	set	set	NOUN
bam-1791	349	10	-	-	PUNCT
bam-1791	349	11	up	up	NOUN
bam-1791	349	12	to	to	PART
bam-1791	349	13	evaluate	evaluate	VERB
bam-1791	349	14	the	the	DET
bam-1791	349	15	mechanical	mechanical	ADJ
bam-1791	349	16	functionality	functionality	NOUN
bam-1791	349	17	of	of	ADP
bam-1791	349	18	the	the	DET
bam-1791	349	19	nmj	nmj	NOUN
bam-1791	349	20	in	in	ADP
bam-1791	349	21	murine	murine	ADJ
bam-1791	349	22	animal	animal	NOUN
bam-1791	349	23	models	model	NOUN
bam-1791	349	24	.	.	PUNCT
bam-1791	350	1	the	the	DET
bam-1791	350	2	experimental	experimental	ADJ
bam-1791	350	3	set	set	NOUN
bam-1791	350	4	-	-	PUNCT
bam-1791	350	5	up	up	NOUN
bam-1791	350	6	,	,	PUNCT
bam-1791	350	7	together	together	ADV
bam-1791	350	8	with	with	ADP
bam-1791	350	9	the	the	DET
bam-1791	350	10	developed	develop	VERB
bam-1791	350	11	software	software	NOUN
bam-1791	350	12	,	,	PUNCT
bam-1791	350	13	allowed	allow	VERB
bam-1791	350	14	for	for	ADP
bam-1791	350	15	the	the	DET
bam-1791	350	16	evaluation	evaluation	NOUN
bam-1791	350	17	of	of	ADP
bam-1791	350	18	the	the	DET
bam-1791	350	19	nmj	nmj	PROPN
bam-1791	350	20	functionality	functionality	NOUN
bam-1791	350	21	through	through	ADP
bam-1791	350	22	the	the	DET
bam-1791	350	23	comparison	comparison	NOUN
bam-1791	350	24	between	between	ADP
bam-1791	350	25	muscle	muscle	NOUN
bam-1791	350	26	response	response	NOUN
bam-1791	350	27	following	follow	VERB
bam-1791	350	28	membrane	membrane	NOUN
bam-1791	350	29	stimulation	stimulation	NOUN
bam-1791	350	30	and	and	CCONJ
bam-1791	350	31	response	response	NOUN
bam-1791	350	32	following	follow	VERB
bam-1791	350	33	nerve	nerve	NOUN
bam-1791	350	34	stimulation	stimulation	NOUN
bam-1791	350	35	.	.	PUNCT
bam-1791	351	1	in	in	ADP
bam-1791	351	2	particular	particular	ADJ
bam-1791	351	3	,	,	PUNCT
bam-1791	351	4	the	the	DET
bam-1791	351	5	electrical	electrical	ADJ
bam-1791	351	6	pulses	pulse	NOUN
bam-1791	351	7	that	that	PRON
bam-1791	351	8	reach	reach	VERB
bam-1791	351	9	the	the	DET
bam-1791	351	10	membrane	membrane	NOUN
bam-1791	351	11	of	of	ADP
bam-1791	351	12	the	the	DET
bam-1791	351	13	muscle	muscle	NOUN
bam-1791	351	14	through	through	ADP
bam-1791	351	15	the	the	DET
bam-1791	351	16	solution	solution	NOUN
bam-1791	351	17	by	by	ADP
bam-1791	351	18	-	-	PUNCT
bam-1791	351	19	pass	pass	VERB
bam-1791	351	20	the	the	DET
bam-1791	351	21	biochemical	biochemical	ADJ
bam-1791	351	22	signaling	signaling	NOUN
bam-1791	351	23	that	that	PRON
bam-1791	351	24	runs	run	VERB
bam-1791	351	25	along	along	ADP
bam-1791	351	26	the	the	DET
bam-1791	351	27	nerve	nerve	NOUN
bam-1791	351	28	;	;	PUNCT
bam-1791	351	29	on	on	ADP
bam-1791	351	30	the	the	DET
bam-1791	351	31	contrary	contrary	NOUN
bam-1791	351	32	,	,	PUNCT
bam-1791	351	33	when	when	SCONJ
bam-1791	351	34	electrical	electrical	ADJ
bam-1791	351	35	pulses	pulse	NOUN
bam-1791	351	36	are	be	AUX
bam-1791	351	37	delivered	deliver	VERB
bam-1791	351	38	directly	directly	ADV
bam-1791	351	39	on	on	ADP
bam-1791	351	40	the	the	DET
bam-1791	351	41	nerve	nerve	NOUN
bam-1791	351	42	,	,	PUNCT
bam-1791	351	43	to	to	PART
bam-1791	351	44	simulate	simulate	VERB
bam-1791	351	45	neuron	neuron	NOUN
bam-1791	351	46	activity	activity	NOUN
bam-1791	351	47	,	,	PUNCT
bam-1791	351	48	the	the	DET
bam-1791	351	49	nerve	nerve	NOUN
bam-1791	351	50	transmission	transmission	NOUN
bam-1791	351	51	pathway	pathway	NOUN
bam-1791	351	52	is	be	AUX
bam-1791	351	53	activated	activate	VERB
bam-1791	351	54	.	.	PUNCT
bam-1791	352	1	the	the	DET
bam-1791	352	2	comparison	comparison	NOUN
bam-1791	352	3	of	of	ADP
bam-1791	352	4	muscle	muscle	NOUN
bam-1791	352	5	response	response	NOUN
bam-1791	352	6	to	to	ADP
bam-1791	352	7	specific	specific	ADJ
bam-1791	352	8	stimulation	stimulation	NOUN
bam-1791	352	9	protocol	protocol	NOUN
bam-1791	352	10	can	can	AUX
bam-1791	352	11	give	give	VERB
bam-1791	352	12	an	an	DET
bam-1791	352	13	in	in	ADP
bam-1791	352	14	-	-	PUNCT
bam-1791	352	15	depth	depth	NOUN
bam-1791	352	16	information	information	NOUN
bam-1791	352	17	on	on	ADP
bam-1791	352	18	the	the	DET
bam-1791	352	19	functionality	functionality	NOUN
bam-1791	352	20	on	on	ADP
bam-1791	352	21	the	the	DET
bam-1791	352	22	nmj	nmj	NOUN
bam-1791	352	23	,	,	PUNCT
bam-1791	352	24	and	and	CCONJ
bam-1791	352	25	possible	possible	ADJ
bam-1791	352	26	discrepancies	discrepancy	NOUN
bam-1791	352	27	in	in	ADP
bam-1791	352	28	the	the	DET
bam-1791	352	29	responses	response	NOUN
bam-1791	352	30	can	can	AUX
bam-1791	352	31	give	give	VERB
bam-1791	352	32	the	the	DET
bam-1791	352	33	rise	rise	NOUN
bam-1791	352	34	to	to	ADP
bam-1791	352	35	further	far	ADV
bam-1791	352	36	morphological	morphological	ADJ
bam-1791	352	37	or	or	CCONJ
bam-1791	352	38	biochemical	biochemical	ADJ
bam-1791	352	39	studies	study	NOUN
bam-1791	352	40	on	on	ADP
bam-1791	352	41	the	the	DET
bam-1791	352	42	nmj	nmj	NOUN
bam-1791	352	43	.	.	PUNCT
bam-1791	353	1	the	the	DET
bam-1791	353	2	set	set	NOUN
bam-1791	353	3	-	-	PUNCT
bam-1791	353	4	up	up	NOUN
bam-1791	353	5	and	and	CCONJ
bam-1791	353	6	the	the	DET
bam-1791	353	7	software	software	NOUN
bam-1791	353	8	have	have	AUX
bam-1791	353	9	been	be	AUX
bam-1791	353	10	developed	develop	VERB
bam-1791	353	11	with	with	ADP
bam-1791	353	12	reference	reference	NOUN
bam-1791	353	13	to	to	ADP
bam-1791	353	14	the	the	DET
bam-1791	353	15	diaphragm	diaphragm	PROPN
bam-1791	353	16	muscle	muscle	NOUN
bam-1791	353	17	,	,	PUNCT
bam-1791	353	18	both	both	PRON
bam-1791	353	19	for	for	ADP
bam-1791	353	20	the	the	DET
bam-1791	353	21	importance	importance	NOUN
bam-1791	353	22	that	that	SCONJ
bam-1791	353	23	it	it	PRON
bam-1791	353	24	owns	own	VERB
bam-1791	353	25	in	in	ADP
bam-1791	353	26	this	this	DET
bam-1791	353	27	pathology	pathology	NOUN
bam-1791	353	28	,	,	PUNCT
bam-1791	353	29	and	and	CCONJ
bam-1791	353	30	for	for	ADP
bam-1791	353	31	the	the	DET
bam-1791	353	32	specimen	speciman	NOUN
bam-1791	353	33	shape	shape	NOUN
bam-1791	353	34	that	that	PRON
bam-1791	353	35	allows	allow	VERB
bam-1791	353	36	to	to	PART
bam-1791	353	37	keep	keep	VERB
bam-1791	353	38	a	a	DET
bam-1791	353	39	piece	piece	NOUN
bam-1791	353	40	of	of	ADP
bam-1791	353	41	tissue	tissue	NOUN
bam-1791	353	42	within	within	ADP
bam-1791	353	43	its	its	PRON
bam-1791	353	44	associated	associated	ADJ
bam-1791	353	45	nerve	nerve	NOUN
bam-1791	353	46	(	(	PUNCT
bam-1791	353	47	phrenic	phrenic	ADJ
bam-1791	353	48	nerve	nerve	NOUN
bam-1791	353	49	)	)	PUNCT
bam-1791	353	50	more	more	ADV
bam-1791	353	51	easily	easily	ADV
bam-1791	353	52	.	.	PUNCT
bam-1791	354	1	with	with	ADP
bam-1791	354	2	this	this	DET
bam-1791	354	3	set	set	NOUN
bam-1791	354	4	-	-	PUNCT
bam-1791	354	5	up	up	NOUN
bam-1791	354	6	,	,	PUNCT
bam-1791	354	7	in	in	ADP
bam-1791	354	8	addition	addition	NOUN
bam-1791	354	9	to	to	ADP
bam-1791	354	10	the	the	DET
bam-1791	354	11	classic	classic	ADJ
bam-1791	354	12	parameters	parameter	NOUN
bam-1791	354	13	that	that	PRON
bam-1791	354	14	can	can	AUX
bam-1791	354	15	be	be	AUX
bam-1791	354	16	measured	measure	VERB
bam-1791	354	17	with	with	ADP
bam-1791	354	18	ex	ex	X
bam-1791	354	19	vivo	vivo	ADJ
bam-1791	354	20	mechanical	mechanical	ADJ
bam-1791	354	21	measurements	measurement	NOUN
bam-1791	354	22	[	[	X
bam-1791	354	23	2	2	NUM
bam-1791	354	24	]	]	PUNCT
bam-1791	354	25	,	,	PUNCT
bam-1791	354	26	nmj	nmj	NOUN
bam-1791	354	27	functionality	functionality	NOUN
bam-1791	354	28	can	can	AUX
bam-1791	354	29	be	be	AUX
bam-1791	354	30	evaluated	evaluate	VERB
bam-1791	354	31	computing	compute	VERB
bam-1791	354	32	new	new	ADJ
bam-1791	354	33	proposed	propose	VERB
bam-1791	354	34	parameters	parameter	NOUN
bam-1791	354	35	,	,	PUNCT
bam-1791	354	36	as	as	ADP
bam-1791	354	37	the	the	DET
bam-1791	354	38	“	"	PUNCT
bam-1791	354	39	neurotransmission	neurotransmission	ADJ
bam-1791	354	40	failure	failure	NOUN
bam-1791	354	41	”	"	PUNCT
bam-1791	354	42	or	or	CCONJ
bam-1791	354	43	the	the	DET
bam-1791	354	44	”	"	PUNCT
bam-1791	354	45	intra	intra	ADJ
bam-1791	354	46	-	-	ADJ
bam-1791	354	47	train	train	ADJ
bam-1791	354	48	fatigue	fatigue	NOUN
bam-1791	354	49	”	"	PUNCT
bam-1791	355	1	[	[	X
bam-1791	355	2	3,4	3,4	NUM
bam-1791	355	3	]	]	PUNCT
bam-1791	355	4	.	.	PUNCT
bam-1791	356	1	1	1	X
bam-1791	356	2	.	.	X
bam-1791	356	3	dobrowolny	dobrowolny	PROPN
bam-1791	356	4	g	g	PROPN
bam-1791	356	5	et	et	PROPN
bam-1791	356	6	al	al	PROPN
bam-1791	356	7	.	.	PUNCT
bam-1791	356	8	(	(	PUNCT
bam-1791	356	9	2008	2008	NUM
bam-1791	356	10	)	)	PUNCT
bam-1791	356	11	.	.	PUNCT
bam-1791	357	1	skeletal	skeletal	ADJ
bam-1791	357	2	muscle	muscle	NOUN
bam-1791	357	3	is	be	AUX
bam-1791	357	4	a	a	DET
bam-1791	357	5	primary	primary	ADJ
bam-1791	357	6	target	target	NOUN
bam-1791	357	7	of	of	ADP
bam-1791	357	8	sod1(g93a)-mediated	sod1(g93a)-mediate	VERB
bam-1791	357	9	toxicity	toxicity	NOUN
bam-1791	357	10	.	.	PUNCT
bam-1791	358	1	cell	cell	NOUN
bam-1791	358	2	metabolism	metabolism	NOUN
bam-1791	358	3	,	,	PUNCT
bam-1791	358	4	nov;8(5	nov;8(5	PROPN
bam-1791	358	5	):	):	PUNCT
bam-1791	358	6	425	425	NUM
bam-1791	358	7	-	-	SYM
bam-1791	358	8	36	36	NUM
bam-1791	358	9	.	.	PUNCT
bam-1791	359	1	2	2	X
bam-1791	359	2	.	.	X
bam-1791	359	3	del	del	PROPN
bam-1791	359	4	prete	prete	PROPN
bam-1791	359	5	z	z	PROPN
bam-1791	359	6	,	,	PUNCT
bam-1791	359	7	musarò	musarò	NOUN
bam-1791	359	8	a	a	DET
bam-1791	359	9	and	and	CCONJ
bam-1791	359	10	rizzuto	rizzuto	NOUN
bam-1791	359	11	e	e	PROPN
bam-1791	359	12	(	(	PUNCT
bam-1791	359	13	2008	2008	NUM
bam-1791	359	14	)	)	PUNCT
bam-1791	359	15	.	.	PUNCT
bam-1791	360	1	measuring	measure	VERB
bam-1791	360	2	mechanical	mechanical	ADJ
bam-1791	360	3	properties	property	NOUN
bam-1791	360	4	,	,	PUNCT
bam-1791	360	5	including	include	VERB
bam-1791	360	6	isotonic	isotonic	ADJ
bam-1791	360	7	fatigue	fatigue	NOUN
bam-1791	360	8	,	,	PUNCT
bam-1791	360	9	of	of	ADP
bam-1791	360	10	fast	fast	ADJ
bam-1791	360	11	and	and	CCONJ
bam-1791	360	12	slow	slow	ADJ
bam-1791	360	13	mlc	mlc	NOUN
bam-1791	360	14	/	/	SYM
bam-1791	360	15	migf-1	migf-1	NUM
bam-1791	360	16	transgenic	transgenic	NOUN
bam-1791	360	17	skeletal	skeletal	ADJ
bam-1791	360	18	muscle	muscle	NOUN
bam-1791	360	19	.	.	PUNCT
bam-1791	361	1	annal	annal	ADJ
bam-1791	361	2	of	of	ADP
bam-1791	361	3	biomedical	biomedical	ADJ
bam-1791	361	4	engineering	engineering	NOUN
bam-1791	361	5	36	36	NUM
bam-1791	361	6	,	,	PUNCT
bam-1791	361	7	1281–1290	1281–1290	NUM
bam-1791	361	8	.	.	PUNCT
bam-1791	362	1	3	3	X
bam-1791	362	2	.	.	X
bam-1791	362	3	personius	personius	PROPN
bam-1791	362	4	k.e	k.e	PROPN
bam-1791	362	5	,	,	PUNCT
bam-1791	362	6	sawyer	sawyer	PROPN
bam-1791	362	7	r.p	r.p	PROPN
bam-1791	362	8	(	(	PUNCT
bam-1791	362	9	2006	2006	NUM
bam-1791	362	10	)	)	PUNCT
bam-1791	362	11	.	.	PUNCT
bam-1791	363	1	variability	variability	NOUN
bam-1791	363	2	and	and	CCONJ
bam-1791	363	3	failure	failure	NOUN
bam-1791	363	4	of	of	ADP
bam-1791	363	5	neurotransmission	neurotransmission	NOUN
bam-1791	363	6	in	in	ADP
bam-1791	363	7	the	the	DET
bam-1791	363	8	diaphragm	diaphragm	NOUN
bam-1791	363	9	of	of	ADP
bam-1791	363	10	mdx	mdx	NOUN
bam-1791	363	11	mice	mouse	NOUN
bam-1791	363	12	.	.	PUNCT
bam-1791	364	1	neuromuscular	neuromuscular	ADJ
bam-1791	364	2	disorders	disorder	NOUN
bam-1791	364	3	,	,	PUNCT
bam-1791	364	4	16	16	NUM
bam-1791	364	5	:	:	PUNCT
bam-1791	364	6	168–177	168–177	NUM
bam-1791	364	7	4	4	NUM
bam-1791	364	8	.	.	PUNCT
bam-1791	365	1	van	van	PROPN
bam-1791	365	2	lunteren	lunteren	PROPN
bam-1791	365	3	e	e	PROPN
bam-1791	365	4	,	,	PUNCT
bam-1791	365	5	moyer	moyer	PROPN
bam-1791	365	6	m	m	PROPN
bam-1791	365	7	,	,	PUNCT
bam-1791	365	8	kaminski	kaminski	PROPN
bam-1791	365	9	h.j	h.j	PROPN
bam-1791	365	10	.	.	PROPN
bam-1791	365	11	(	(	PUNCT
bam-1791	365	12	2004	2004	NUM
bam-1791	365	13	)	)	PUNCT
bam-1791	365	14	.	.	PUNCT
bam-1791	366	1	adverse	adverse	ADJ
bam-1791	366	2	effects	effect	NOUN
bam-1791	366	3	of	of	ADP
bam-1791	366	4	myasthenia	myasthenia	NOUN
bam-1791	366	5	gravis	gravis	NOUN
bam-1791	366	6	on	on	ADP
bam-1791	366	7	rat	rat	NOUN
bam-1791	366	8	phrenic	phrenic	ADJ
bam-1791	366	9	diaphragm	diaphragm	NOUN
bam-1791	366	10	contractile	contractile	NOUN
bam-1791	366	11	performance	performance	NOUN
bam-1791	366	12	.	.	PUNCT
bam-1791	367	1	journal	journal	NOUN
bam-1791	367	2	of	of	ADP
bam-1791	367	3	applied	apply	VERB
bam-1791	367	4	physiology	physiology	NOUN
bam-1791	367	5	97	97	NUM
bam-1791	367	6	:	:	PUNCT
bam-1791	367	7	895–901	895–901	NUM
bam-1791	367	8	.	.	NOUN
bam-1791	367	9	31	31	NUM
bam-1791	367	10	.	.	PUNCT
bam-1791	368	1	post	post	ADJ
bam-1791	368	2	-	-	ADJ
bam-1791	368	3	natal	natal	ADJ
bam-1791	368	4	molecular	molecular	ADJ
bam-1791	368	5	and	and	CCONJ
bam-1791	368	6	morphological	morphological	ADJ
bam-1791	368	7	adaptive	adaptive	ADJ
bam-1791	368	8	changes	change	NOUN
bam-1791	368	9	in	in	ADP
bam-1791	368	10	a	a	DET
bam-1791	368	11	mouse	mouse	NOUN
bam-1791	368	12	model	model	NOUN
bam-1791	368	13	of	of	ADP
bam-1791	368	14	recessive	recessive	ADJ
bam-1791	368	15	cpvt	cpvt	PROPN
bam-1791	368	16	g.	g.	PROPN
bam-1791	368	17	valle1	valle1	PROPN
bam-1791	368	18	,	,	PUNCT
bam-1791	368	19	s.	s.	PROPN
bam-1791	368	20	boncompagni2	boncompagni2	PROPN
bam-1791	368	21	,	,	PUNCT
bam-1791	368	22	f.	f.	PROPN
bam-1791	368	23	protasi2	protasi2	PROPN
bam-1791	368	24	,	,	PUNCT
bam-1791	368	25	s.g	s.g	PROPN
bam-1791	368	26	.	.	PROPN
bam-1791	368	27	priori3	priori3	PROPN
bam-1791	368	28	,	,	PUNCT
bam-1791	368	29	p.	p.	NOUN
bam-1791	368	30	volpe1	volpe1	NOUN
bam-1791	368	31	1dsb	1dsb	NOUN
bam-1791	368	32	,	,	PUNCT
bam-1791	368	33	università	università	PROPN
bam-1791	368	34	di	di	PROPN
bam-1791	368	35	padova	padova	PROPN
bam-1791	368	36	;	;	PUNCT
bam-1791	368	37	2dni	2dni	NUM
bam-1791	368	38	,	,	PUNCT
bam-1791	368	39	università	università	PROPN
bam-1791	368	40	g.	g.	PROPN
bam-1791	368	41	d’annunzio	d’annunzio	PROPN
bam-1791	368	42	,	,	PUNCT
bam-1791	368	43	chieti	chieti	PROPN
bam-1791	368	44	;	;	PUNCT
bam-1791	368	45	3dmm	3dmm	NUM
bam-1791	368	46	,	,	PUNCT
bam-1791	368	47	università	università	PROPN
bam-1791	368	48	di	di	PROPN
bam-1791	368	49	pavia	pavia	PROPN
bam-1791	368	50	the	the	DET
bam-1791	368	51	sarcoplasmic	sarcoplasmic	NOUN
bam-1791	368	52	reticulum	reticulum	NOUN
bam-1791	368	53	(	(	PUNCT
bam-1791	368	54	sr	sr	PROPN
bam-1791	368	55	)	)	PUNCT
bam-1791	368	56	is	be	AUX
bam-1791	368	57	responsible	responsible	ADJ
bam-1791	368	58	for	for	ADP
bam-1791	368	59	calcium	calcium	NOUN
bam-1791	368	60	cycling	cycling	NOUN
bam-1791	368	61	in	in	ADP
bam-1791	368	62	heart	heart	NOUN
bam-1791	368	63	.	.	PUNCT
bam-1791	369	1	cardiac	cardiac	ADJ
bam-1791	369	2	calsequestrin	calsequestrin	PROPN
bam-1791	369	3	(	(	PUNCT
bam-1791	369	4	casq2	casq2	PROPN
bam-1791	369	5	)	)	PUNCT
bam-1791	369	6	contributes	contribute	VERB
bam-1791	369	7	to	to	ADP
bam-1791	369	8	calcium	calcium	NOUN
bam-1791	369	9	homeostasis	homeostasis	NOUN
bam-1791	369	10	by	by	ADP
bam-1791	369	11	virtue	virtue	NOUN
bam-1791	369	12	of	of	ADP
bam-1791	369	13	its	its	PRON
bam-1791	369	14	low	low	ADJ
bam-1791	369	15	-	-	PUNCT
bam-1791	369	16	affinity	affinity	NOUN
bam-1791	369	17	/	/	SYM
bam-1791	369	18	high	high	ADJ
bam-1791	369	19	-	-	PUNCT
bam-1791	369	20	capacity	capacity	NOUN
bam-1791	369	21	calcium	calcium	NOUN
bam-1791	369	22	binding	bind	VERB
bam-1791	369	23	properties	property	NOUN
bam-1791	369	24	,	,	PUNCT
bam-1791	369	25	maintains	maintain	VERB
bam-1791	369	26	sr	sr	PROPN
bam-1791	369	27	architecture	architecture	NOUN
bam-1791	369	28	and	and	CCONJ
bam-1791	369	29	regulates	regulate	VERB
bam-1791	369	30	excitation	excitation	NOUN
bam-1791	369	31	-	-	PUNCT
bam-1791	369	32	contraction	contraction	NOUN
bam-1791	369	33	-	-	PUNCT
bam-1791	369	34	coupling	coupling	NOUN
bam-1791	369	35	,	,	PUNCT
bam-1791	369	36	especially	especially	ADV
bam-1791	369	37	or	or	CCONJ
bam-1791	369	38	exclusively	exclusively	ADV
bam-1791	369	39	upon	upon	SCONJ
bam-1791	369	40	β	β	ADJ
bam-1791	369	41	-	-	ADJ
bam-1791	369	42	adrenergic	adrenergic	ADJ
bam-1791	369	43	stimulation	stimulation	NOUN
bam-1791	369	44	.	.	PUNCT
bam-1791	370	1	catecholaminergic	catecholaminergic	ADJ
bam-1791	370	2	polymorphic	polymorphic	ADJ
bam-1791	370	3	ventricular	ventricular	ADJ
bam-1791	370	4	tachycardia	tachycardia	NOUN
bam-1791	370	5	(	(	PUNCT
bam-1791	370	6	cpvt	cpvt	PROPN
bam-1791	370	7	)	)	PUNCT
bam-1791	370	8	is	be	AUX
bam-1791	370	9	an	an	DET
bam-1791	370	10	inherited	inherit	VERB
bam-1791	370	11	arrhythmogenic	arrhythmogenic	ADJ
bam-1791	370	12	disease	disease	NOUN
bam-1791	370	13	associated	associate	VERB
bam-1791	370	14	with	with	ADP
bam-1791	370	15	cardiac	cardiac	ADJ
bam-1791	370	16	arrest	arrest	NOUN
bam-1791	370	17	in	in	ADP
bam-1791	370	18	children	child	NOUN
bam-1791	370	19	or	or	CCONJ
bam-1791	370	20	young	young	ADJ
bam-1791	370	21	adults	adult	NOUN
bam-1791	370	22	.	.	PUNCT
bam-1791	371	1	the	the	DET
bam-1791	371	2	recessive	recessive	ADJ
bam-1791	371	3	cpvt	cpvt	PROPN
bam-1791	371	4	variants	variant	NOUN
bam-1791	371	5	are	be	AUX
bam-1791	371	6	due	due	ADJ
bam-1791	371	7	to	to	ADP
bam-1791	371	8	mutations	mutation	NOUN
bam-1791	371	9	in	in	ADP
bam-1791	371	10	either	either	CCONJ
bam-1791	371	11	the	the	DET
bam-1791	371	12	casq2	casq2	NOUN
bam-1791	371	13	gene	gene	NOUN
bam-1791	371	14	or	or	CCONJ
bam-1791	371	15	the	the	DET
bam-1791	371	16	triadin	triadin	NOUN
bam-1791	371	17	gene	gene	NOUN
bam-1791	371	18	.	.	PUNCT
bam-1791	372	1	since	since	SCONJ
bam-1791	372	2	the	the	DET
bam-1791	372	3	content	content	NOUN
bam-1791	372	4	of	of	ADP
bam-1791	372	5	casq2	casq2	PROPN
bam-1791	372	6	-	-	PUNCT
bam-1791	372	7	r33q	r33q	PROPN
bam-1791	372	8	was	be	AUX
bam-1791	372	9	drastically	drastically	ADV
bam-1791	372	10	reduced	reduce	VERB
bam-1791	372	11	in	in	ADP
bam-1791	372	12	heart	heart	NOUN
bam-1791	372	13	of	of	ADP
bam-1791	372	14	adult	adult	NOUN
bam-1791	372	15	casq2r33q	casq2r33q	NOUN
bam-1791	372	16	/	/	SYM
bam-1791	372	17	r33q	r33q	ADJ
bam-1791	372	18	mice	mouse	NOUN
bam-1791	372	19	,	,	PUNCT
bam-1791	372	20	the	the	DET
bam-1791	372	21	post	post	ADJ
bam-1791	372	22	-	-	ADJ
bam-1791	372	23	natal	natal	ADJ
bam-1791	372	24	development	development	NOUN
bam-1791	372	25	was	be	AUX
bam-1791	372	26	studied	study	VERB
bam-1791	372	27	from	from	ADP
bam-1791	372	28	day	day	NOUN
bam-1791	372	29	2	2	NUM
bam-1791	372	30	to	to	ADP
bam-1791	372	31	week	week	NOUN
bam-1791	372	32	8	8	NUM
bam-1791	372	33	.	.	PUNCT
bam-1791	373	1	the	the	DET
bam-1791	373	2	main	main	ADJ
bam-1791	373	3	findings	finding	NOUN
bam-1791	373	4	are	be	AUX
bam-1791	373	5	:	:	PUNCT
bam-1791	373	6	a	a	X
bam-1791	373	7	)	)	PUNCT
bam-1791	373	8	80	80	NUM
bam-1791	373	9	%	%	NOUN
bam-1791	373	10	reduction	reduction	NOUN
bam-1791	373	11	of	of	ADP
bam-1791	373	12	casq2	casq2	PROPN
bam-1791	373	13	-	-	PUNCT
bam-1791	373	14	r33q	r33q	PROPN
bam-1791	373	15	is	be	AUX
bam-1791	373	16	an	an	DET
bam-1791	373	17	early	early	ADJ
bam-1791	373	18	event	event	NOUN
bam-1791	373	19	in	in	ADP
bam-1791	373	20	the	the	DET
bam-1791	373	21	post	post	ADJ
bam-1791	373	22	-	-	ADJ
bam-1791	373	23	natal	natal	ADJ
bam-1791	373	24	development	development	NOUN
bam-1791	373	25	and	and	CCONJ
bam-1791	373	26	is	be	AUX
bam-1791	373	27	accompanied	accompany	VERB
bam-1791	373	28	by	by	ADP
bam-1791	373	29	a	a	DET
bam-1791	373	30	drastic	drastic	ADJ
bam-1791	373	31	reduction	reduction	NOUN
bam-1791	373	32	of	of	ADP
bam-1791	373	33	triadin	triadin	NOUN
bam-1791	373	34	;	;	PUNCT
bam-1791	373	35	b	b	X
bam-1791	373	36	)	)	PUNCT
bam-1791	373	37	grp78	grp78	NOUN
bam-1791	373	38	levels	level	NOUN
bam-1791	373	39	are	be	AUX
bam-1791	373	40	elevated	elevate	VERB
bam-1791	373	41	as	as	ADP
bam-1791	373	42	evidence	evidence	NOUN
bam-1791	373	43	of	of	ADP
bam-1791	373	44	er	er	INTJ
bam-1791	373	45	stress	stress	NOUN
bam-1791	373	46	and	and	CCONJ
bam-1791	373	47	upr	upr	ADJ
bam-1791	373	48	;	;	PUNCT
bam-1791	373	49	c	c	X
bam-1791	373	50	)	)	PUNCT
bam-1791	373	51	no	no	DET
bam-1791	373	52	signs	sign	NOUN
bam-1791	373	53	of	of	ADP
bam-1791	373	54	either	either	CCONJ
bam-1791	373	55	apoptosis	apoptosis	NOUN
bam-1791	373	56	or	or	CCONJ
bam-1791	373	57	autophagy	autophagy	NOUN
bam-1791	373	58	are	be	AUX
bam-1791	373	59	detected	detect	VERB
bam-1791	373	60	;	;	PUNCT
bam-1791	373	61	on	on	ADP
bam-1791	373	62	the	the	DET
bam-1791	373	63	contrary	contrary	NOUN
bam-1791	373	64	,	,	PUNCT
bam-1791	373	65	prosurvival	prosurvival	NOUN
bam-1791	373	66	signals	signal	NOUN
bam-1791	373	67	are	be	AUX
bam-1791	373	68	activated	activate	VERB
bam-1791	373	69	in	in	ADP
bam-1791	373	70	2	2	NUM
bam-1791	373	71	-	-	PUNCT
bam-1791	373	72	week	week	NOUN
bam-1791	373	73	-	-	PUNCT
bam-1791	373	74	old	old	ADJ
bam-1791	373	75	hearts	heart	NOUN
bam-1791	373	76	,	,	PUNCT
bam-1791	373	77	as	as	SCONJ
bam-1791	373	78	inferred	infer	VERB
bam-1791	373	79	by	by	ADP
bam-1791	373	80	increase	increase	NOUN
bam-1791	373	81	of	of	ADP
bam-1791	373	82	bcl-2	bcl-2	PUNCT
bam-1791	373	83	and	and	CCONJ
bam-1791	373	84	by	by	ADP
bam-1791	373	85	activation	activation	NOUN
bam-1791	373	86	of	of	ADP
bam-1791	373	87	akt	akt	PROPN
bam-1791	373	88	and	and	CCONJ
bam-1791	373	89	erk1/2	erk1/2	PROPN
bam-1791	373	90	pathways	pathway	NOUN
bam-1791	373	91	;	;	PUNCT
bam-1791	374	1	d	d	X
bam-1791	374	2	)	)	PUNCT
bam-1791	374	3	the	the	DET
bam-1791	374	4	transcription	transcription	NOUN
bam-1791	374	5	factor	factor	NOUN
bam-1791	374	6	egr-1	egr-1	NUM
bam-1791	374	7	is	be	AUX
bam-1791	374	8	up	up	ADV
bam-1791	374	9	-	-	PUNCT
bam-1791	374	10	regulated	regulate	VERB
bam-1791	374	11	as	as	ADV
bam-1791	374	12	well	well	ADV
bam-1791	374	13	as	as	ADP
bam-1791	374	14	egr-1	egr-1	NUM
bam-1791	374	15	-	-	PUNCT
bam-1791	374	16	dependent	dependent	ADJ
bam-1791	374	17	calcium	calcium	NOUN
bam-1791	374	18	-	-	PUNCT
bam-1791	374	19	regulating	regulate	VERB
bam-1791	374	20	proteins	protein	NOUN
bam-1791	374	21	,	,	PUNCT
bam-1791	374	22	e.g.	e.g.	ADV
bam-1791	374	23	,	,	PUNCT
bam-1791	374	24	stim1	stim1	NOUN
bam-1791	374	25	;	;	PUNCT
bam-1791	374	26	e	e	X
bam-1791	374	27	)	)	PUNCT
bam-1791	374	28	morphological	morphological	ADJ
bam-1791	374	29	changes	change	NOUN
bam-1791	374	30	of	of	ADP
bam-1791	374	31	jsr	jsr	PROPN
bam-1791	374	32	and	and	CCONJ
bam-1791	374	33	of	of	ADP
bam-1791	374	34	sr	sr	PROPN
bam-1791	374	35	-	-	PUNCT
bam-1791	374	36	t	t	PROPN
bam-1791	374	37	tubule	tubule	NOUN
bam-1791	374	38	junction	junction	NOUN
bam-1791	374	39	are	be	AUX
bam-1791	374	40	evident	evident	ADJ
bam-1791	374	41	as	as	ADP
bam-1791	374	42	post	post	ADJ
bam-1791	374	43	-	-	ADJ
bam-1791	374	44	natal	natal	ADJ
bam-1791	374	45	day	day	NOUN
bam-1791	374	46	2	2	NUM
bam-1791	374	47	;	;	PUNCT
bam-1791	374	48	f	f	X
bam-1791	374	49	)	)	PUNCT
bam-1791	374	50	yet	yet	ADV
bam-1791	374	51	another	another	DET
bam-1791	374	52	model	model	NOUN
bam-1791	374	53	of	of	ADP
bam-1791	374	54	recessive	recessive	ADJ
bam-1791	374	55	cpvt	cpvt	NOUN
bam-1791	374	56	,	,	PUNCT
bam-1791	374	57	the	the	DET
bam-1791	374	58	casq2-/mouse	casq2-/mouse	PROPN
bam-1791	374	59	,	,	PUNCT
bam-1791	374	60	does	do	AUX
bam-1791	374	61	not	not	PART
bam-1791	374	62	display	display	VERB
bam-1791	374	63	the	the	DET
bam-1791	374	64	same	same	ADJ
bam-1791	374	65	adaptive	adaptive	ADJ
bam-1791	374	66	pattern	pattern	NOUN
bam-1791	374	67	.	.	PUNCT
bam-1791	375	1	expression	expression	NOUN
bam-1791	375	2	of	of	ADP
bam-1791	375	3	casq2	casq2	PROPN
bam-1791	375	4	-	-	PUNCT
bam-1791	375	5	r33q	r33q	PROPN
bam-1791	375	6	influences	influence	NOUN
bam-1791	375	7	molecular	molecular	ADJ
bam-1791	375	8	and	and	CCONJ
bam-1791	375	9	ultra	ultra	ADJ
bam-1791	375	10	-	-	ADJ
bam-1791	375	11	structural	structural	ADJ
bam-1791	375	12	heart	heart	NOUN
bam-1791	375	13	development	development	NOUN
bam-1791	375	14	;	;	PUNCT
bam-1791	375	15	post	post	ADJ
bam-1791	375	16	-	-	ADJ
bam-1791	375	17	natal	natal	ADJ
bam-1791	375	18	,	,	PUNCT
bam-1791	375	19	adaptive	adaptive	ADJ
bam-1791	375	20	changes	change	NOUN
bam-1791	375	21	appear	appear	VERB
bam-1791	375	22	to	to	PART
bam-1791	375	23	be	be	AUX
bam-1791	375	24	pro	pro	ADJ
bam-1791	375	25	-	-	ADJ
bam-1791	375	26	survival	survival	ADJ
bam-1791	375	27	,	,	PUNCT
bam-1791	375	28	capable	capable	ADJ
bam-1791	375	29	of	of	ADP
bam-1791	375	30	ensuring	ensure	VERB
bam-1791	375	31	a	a	DET
bam-1791	375	32	new	new	ADJ
bam-1791	375	33	equilibrium	equilibrium	NOUN
bam-1791	375	34	to	to	PART
bam-1791	375	35	be	be	AUX
bam-1791	375	36	hampered	hamper	VERB
bam-1791	375	37	only	only	ADV
bam-1791	375	38	under	under	ADP
bam-1791	375	39	emotional	emotional	ADJ
bam-1791	375	40	stress	stress	NOUN
bam-1791	375	41	or	or	CCONJ
bam-1791	375	42	βadrenergic	βadrenergic	ADJ
bam-1791	375	43	stimulations	stimulation	NOUN
bam-1791	375	44	.	.	PUNCT
bam-1791	376	1	ix	ix	ADP
bam-1791	376	2	iim	iim	PROPN
bam-1791	376	3	meeting	meeting	NOUN
bam-1791	376	4	,	,	PUNCT
bam-1791	376	5	acaya	acaya	NOUN
bam-1791	376	6	(	(	PUNCT
bam-1791	376	7	lecce	lecce	PROPN
bam-1791	376	8	)	)	PUNCT
bam-1791	376	9	,	,	PUNCT
bam-1791	376	10	october	october	PROPN
bam-1791	376	11	12	12	NUM
bam-1791	376	12	-	-	SYM
bam-1791	376	13	14	14	NUM
bam-1791	376	14	,	,	PUNCT
bam-1791	376	15	2012	2012	NUM
bam-1791	376	16	european	european	PROPN
bam-1791	376	17	journal	journal	PROPN
bam-1791	376	18	translational	translational	ADJ
bam-1791	376	19	myology	myology	NOUN
bam-1791	376	20	basic	basic	ADJ
bam-1791	376	21	applied	apply	VERB
bam-1791	376	22	myology	myology	NOUN
bam-1791	376	23	2012	2012	NUM
bam-1791	376	24	;	;	PUNCT
bam-1791	376	25	22(1&2	22(1&2	NUM
bam-1791	376	26	):	):	PUNCT
bam-1791	376	27	xxx	xxx	NOUN
bam-1791	376	28	-	-	PUNCT
bam-1791	376	29	xxx	xxx	NOUN
bam-1791	376	30	34	34	NUM
bam-1791	376	31	session	session	NOUN
bam-1791	376	32	6	6	NUM
bam-1791	376	33	muscle	muscle	NOUN
bam-1791	376	34	atrophy	atrophy	NOUN
bam-1791	376	35	and	and	CCONJ
bam-1791	376	36	aging	age	VERB
bam-1791	376	37	32	32	NUM
bam-1791	376	38	.	.	PUNCT
bam-1791	377	1	targeting	target	VERB
bam-1791	377	2	integrin	integrin	NOUN
bam-1791	377	3	signalling	signal	VERB
bam-1791	377	4	prevents	prevent	VERB
bam-1791	377	5	starvation	starvation	NOUN
bam-1791	377	6	-	-	PUNCT
bam-1791	377	7	induced	induce	VERB
bam-1791	377	8	autophagy	autophagy	NOUN
bam-1791	377	9	via	via	ADP
bam-1791	377	10	jnk	jnk	PROPN
bam-1791	377	11	/	/	SYM
bam-1791	377	12	p38	p38	NOUN
bam-1791	377	13	mediated	mediate	VERB
bam-1791	377	14	regulation	regulation	NOUN
bam-1791	377	15	of	of	ADP
bam-1791	377	16	mir-21	mir-21	PROPN
bam-1791	377	17	madaro	madaro	NOUN
bam-1791	377	18	l.1	l.1	PROPN
bam-1791	377	19	,	,	PUNCT
bam-1791	377	20	saccone	saccone	NOUN
bam-1791	377	21	v.2	v.2	NOUN
bam-1791	377	22	,	,	PUNCT
bam-1791	377	23	marrocco	marrocco	PROPN
bam-1791	377	24	v.1	v.1	NUM
bam-1791	377	25	,	,	PUNCT
bam-1791	377	26	puri	puri	PROPN
bam-1791	377	27	p.l	p.l	PROPN
bam-1791	377	28	.	.	PROPN
bam-1791	377	29	2	2	NUM
bam-1791	377	30	and	and	CCONJ
bam-1791	377	31	bouchè	bouchè	VERB
bam-1791	377	32	m.1	m.1	NOUN
bam-1791	377	33	1	1	NUM
bam-1791	377	34	:	:	PUNCT
bam-1791	377	35	dahfmo	dahfmo	NOUN
bam-1791	377	36	,	,	PUNCT
bam-1791	377	37	unit	unit	NOUN
bam-1791	377	38	of	of	ADP
bam-1791	377	39	istology	istology	NOUN
bam-1791	377	40	,	,	PUNCT
bam-1791	377	41	la	la	PROPN
bam-1791	377	42	sapienza	sapienza	PROPN
bam-1791	377	43	university	university	PROPN
bam-1791	377	44	of	of	ADP
bam-1791	377	45	rome	rome	PROPN
bam-1791	377	46	2	2	NUM
bam-1791	377	47	:	:	PUNCT
bam-1791	377	48	dulbecco	dulbecco	NOUN
bam-1791	377	49	telethon	telethon	NOUN
bam-1791	377	50	istitute	istitute	NOUN
bam-1791	377	51	(	(	PUNCT
bam-1791	377	52	dti	dti	PROPN
bam-1791	377	53	)	)	PUNCT
bam-1791	377	54	,	,	PUNCT
bam-1791	377	55	irccs	ircc	VERB
bam-1791	377	56	fondazione	fondazione	PROPN
bam-1791	377	57	santa	santa	PROPN
bam-1791	377	58	lucia	lucia	PROPN
bam-1791	377	59	,	,	PUNCT
bam-1791	377	60	rome	rome	PROPN
bam-1791	377	61	,	,	PUNCT
bam-1791	377	62	italy	italy	PROPN
bam-1791	377	63	cell	cell	NOUN
bam-1791	377	64	proliferation	proliferation	NOUN
bam-1791	377	65	,	,	PUNCT
bam-1791	377	66	migration	migration	NOUN
bam-1791	377	67	and	and	CCONJ
bam-1791	377	68	survival	survival	NOUN
bam-1791	377	69	are	be	AUX
bam-1791	377	70	controlled	control	VERB
bam-1791	377	71	by	by	ADP
bam-1791	377	72	cytokines	cytokine	NOUN
bam-1791	377	73	including	include	VERB
bam-1791	377	74	growth	growth	NOUN
bam-1791	377	75	factors	factor	NOUN
bam-1791	377	76	and	and	CCONJ
bam-1791	377	77	by	by	ADP
bam-1791	377	78	components	component	NOUN
bam-1791	377	79	of	of	ADP
bam-1791	377	80	the	the	DET
bam-1791	377	81	extracellular	extracellular	ADJ
bam-1791	377	82	matrix	matrix	NOUN
bam-1791	377	83	.	.	PUNCT
bam-1791	378	1	integrin	integrin	NOUN
bam-1791	378	2	receptors	receptor	NOUN
bam-1791	378	3	functionally	functionally	ADV
bam-1791	378	4	link	link	VERB
bam-1791	378	5	extra	extra	ADJ
bam-1791	378	6	-	-	ADJ
bam-1791	378	7	cellular	cellular	ADJ
bam-1791	378	8	matrix	matrix	NOUN
bam-1791	378	9	components	component	NOUN
bam-1791	378	10	,	,	PUNCT
bam-1791	378	11	such	such	ADJ
bam-1791	378	12	as	as	ADP
bam-1791	378	13	collagen	collagen	NOUN
bam-1791	378	14	or	or	CCONJ
bam-1791	378	15	laminin	laminin	NOUN
bam-1791	378	16	to	to	ADP
bam-1791	378	17	intracellular	intracellular	ADJ
bam-1791	378	18	signalling	signal	VERB
bam-1791	378	19	molecules	molecule	NOUN
bam-1791	378	20	such	such	ADJ
bam-1791	378	21	as	as	ADP
bam-1791	378	22	focal	focal	ADJ
bam-1791	378	23	adhesion	adhesion	NOUN
bam-1791	378	24	kinase	kinase	NOUN
bam-1791	378	25	(	(	PUNCT
bam-1791	378	26	fak	fak	PROPN
bam-1791	378	27	)	)	PUNCT
bam-1791	378	28	or	or	CCONJ
bam-1791	378	29	src	src	NOUN
bam-1791	378	30	.	.	PUNCT
bam-1791	379	1	lack	lack	NOUN
bam-1791	379	2	of	of	ADP
bam-1791	379	3	extra	extra	ADJ
bam-1791	379	4	-	-	ADJ
bam-1791	379	5	cellular	cellular	ADJ
bam-1791	379	6	components	component	NOUN
bam-1791	379	7	leads	lead	VERB
bam-1791	379	8	to	to	ADP
bam-1791	379	9	different	different	ADJ
bam-1791	379	10	muscle	muscle	NOUN
bam-1791	379	11	pathologies	pathology	NOUN
bam-1791	379	12	such	such	ADJ
bam-1791	379	13	as	as	ADP
bam-1791	379	14	congenital	congenital	ADJ
bam-1791	379	15	muscular	muscular	ADJ
bam-1791	379	16	dystrophy	dystrophy	NOUN
bam-1791	379	17	or	or	CCONJ
bam-1791	379	18	bethlem	bethlem	NOUN
bam-1791	379	19	myopathy	myopathy	ADJ
bam-1791	379	20	.	.	PUNCT
bam-1791	380	1	col6a-/mice	col6a-/mice	NOUN
bam-1791	380	2	,	,	PUNCT
bam-1791	380	3	as	as	ADP
bam-1791	380	4	model	model	NOUN
bam-1791	380	5	of	of	ADP
bam-1791	380	6	the	the	DET
bam-1791	380	7	bethlem	bethlem	ADJ
bam-1791	380	8	disease	disease	NOUN
bam-1791	380	9	,	,	PUNCT
bam-1791	380	10	are	be	AUX
bam-1791	380	11	characterized	characterize	VERB
bam-1791	380	12	by	by	ADP
bam-1791	380	13	a	a	DET
bam-1791	380	14	block	block	NOUN
bam-1791	380	15	of	of	ADP
bam-1791	380	16	the	the	DET
bam-1791	380	17	autophagic	autophagic	ADJ
bam-1791	380	18	machinery	machinery	NOUN
bam-1791	380	19	as	as	ADP
bam-1791	380	20	a	a	DET
bam-1791	380	21	primary	primary	ADJ
bam-1791	380	22	source	source	NOUN
bam-1791	380	23	of	of	ADP
bam-1791	380	24	muscle	muscle	NOUN
bam-1791	380	25	damage	damage	NOUN
bam-1791	380	26	.	.	PUNCT
bam-1791	381	1	we	we	PRON
bam-1791	381	2	investigated	investigate	VERB
bam-1791	381	3	the	the	DET
bam-1791	381	4	involvement	involvement	NOUN
bam-1791	381	5	of	of	ADP
bam-1791	381	6	integrins	integrin	NOUN
bam-1791	381	7	signalling	signal	VERB
bam-1791	381	8	in	in	ADP
bam-1791	381	9	the	the	DET
bam-1791	381	10	control	control	NOUN
bam-1791	381	11	of	of	ADP
bam-1791	381	12	autophagy	autophagy	NOUN
bam-1791	381	13	in	in	ADP
bam-1791	381	14	muscle	muscle	NOUN
bam-1791	381	15	cells	cell	NOUN
bam-1791	381	16	.	.	PUNCT
bam-1791	382	1	in	in	ADP
bam-1791	382	2	-	-	PUNCT
bam-1791	382	3	vitro	vitro	X
bam-1791	382	4	studies	study	NOUN
bam-1791	382	5	,	,	PUNCT
bam-1791	382	6	revealed	reveal	VERB
bam-1791	382	7	that	that	SCONJ
bam-1791	382	8	pharmacological	pharmacological	ADJ
bam-1791	382	9	inhibition	inhibition	NOUN
bam-1791	382	10	of	of	ADP
bam-1791	382	11	fak	fak	NOUN
bam-1791	382	12	(	(	PUNCT
bam-1791	382	13	using	use	VERB
bam-1791	382	14	f14	f14	PROPN
bam-1791	382	15	inhibitor	inhibitor	NOUN
bam-1791	382	16	)	)	PUNCT
bam-1791	382	17	,	,	PUNCT
bam-1791	382	18	prevented	prevent	VERB
bam-1791	382	19	autophagy	autophagy	ADV
bam-1791	382	20	during	during	ADP
bam-1791	382	21	nutrient	nutrient	ADJ
bam-1791	382	22	deprivation	deprivation	NOUN
bam-1791	382	23	in	in	ADP
bam-1791	382	24	c2c12	c2c12	NOUN
bam-1791	382	25	cells	cell	NOUN
bam-1791	382	26	.	.	PUNCT
bam-1791	383	1	in	in	ADP
bam-1791	383	2	particular	particular	ADJ
bam-1791	383	3	,	,	PUNCT
bam-1791	383	4	f14	f14	PROPN
bam-1791	383	5	prevented	prevent	VERB
bam-1791	383	6	starvation	starvation	NOUN
bam-1791	383	7	-	-	PUNCT
bam-1791	383	8	induced	induce	VERB
bam-1791	383	9	inactivation	inactivation	NOUN
bam-1791	383	10	of	of	ADP
bam-1791	383	11	akt	akt	PROPN
bam-1791	383	12	/	/	SYM
bam-1791	383	13	foxo	foxo	PROPN
bam-1791	383	14	axis	axis	NOUN
bam-1791	383	15	,	,	PUNCT
bam-1791	383	16	while	while	SCONJ
bam-1791	383	17	it	it	PRON
bam-1791	383	18	strongly	strongly	ADV
bam-1791	383	19	induced	induce	VERB
bam-1791	383	20	p38	p38	NOUN
bam-1791	383	21	and	and	CCONJ
bam-1791	383	22	jnk	jnk	PROPN
bam-1791	383	23	activities	activity	NOUN
bam-1791	383	24	.	.	PUNCT
bam-1791	384	1	those	those	DET
bam-1791	384	2	mapks	mapks	NOUN
bam-1791	384	3	in	in	ADP
bam-1791	384	4	turn	turn	NOUN
bam-1791	384	5	activate	activate	VERB
bam-1791	384	6	the	the	DET
bam-1791	384	7	expression	expression	NOUN
bam-1791	384	8	of	of	ADP
bam-1791	384	9	mir-21	mir-21	PROPN
bam-1791	384	10	;	;	PUNCT
bam-1791	384	11	indeed	indeed	ADV
bam-1791	384	12	,	,	PUNCT
bam-1791	384	13	pharmacological	pharmacological	ADJ
bam-1791	384	14	inhibition	inhibition	NOUN
bam-1791	384	15	of	of	ADP
bam-1791	384	16	both	both	DET
bam-1791	384	17	p38	p38	NOUN
bam-1791	384	18	and	and	CCONJ
bam-1791	384	19	jnk	jnk	PROPN
bam-1791	384	20	prevented	prevent	VERB
bam-1791	384	21	mir-21	mir-21	PROPN
bam-1791	384	22	up	up	ADP
bam-1791	384	23	-	-	PUNCT
bam-1791	384	24	regulation	regulation	NOUN
bam-1791	384	25	while	while	SCONJ
bam-1791	384	26	inducing	induce	VERB
bam-1791	384	27	akt	akt	PROPN
bam-1791	384	28	dephosphorilation	dephosphorilation	NOUN
bam-1791	384	29	.	.	PUNCT
bam-1791	385	1	these	these	DET
bam-1791	385	2	results	result	NOUN
bam-1791	385	3	demonstrate	demonstrate	VERB
bam-1791	385	4	that	that	SCONJ
bam-1791	385	5	fak	fak	PROPN
bam-1791	385	6	inhibition	inhibition	NOUN
bam-1791	385	7	during	during	ADP
bam-1791	385	8	starvation	starvation	NOUN
bam-1791	385	9	induces	induce	VERB
bam-1791	385	10	the	the	DET
bam-1791	385	11	activation	activation	NOUN
bam-1791	385	12	of	of	ADP
bam-1791	385	13	the	the	DET
bam-1791	385	14	p38	p38	PROPN
bam-1791	385	15	/	/	SYM
bam-1791	385	16	jnk	jnk	PROPN
bam-1791	385	17	-	-	PUNCT
bam-1791	385	18	mir-21	mir-21	PROPN
bam-1791	385	19	axis	axis	NOUN
bam-1791	385	20	,	,	PUNCT
bam-1791	385	21	which	which	PRON
bam-1791	385	22	in	in	ADP
bam-1791	385	23	turn	turn	NOUN
bam-1791	385	24	maintains	maintain	VERB
bam-1791	385	25	akt	akt	PROPN
bam-1791	385	26	activity	activity	NOUN
bam-1791	385	27	preventing	prevent	VERB
bam-1791	385	28	autophagy	autophagy	NOUN
bam-1791	385	29	.	.	PUNCT
bam-1791	386	1	mir-21	mir-21	PROPN
bam-1791	386	2	may	may	AUX
bam-1791	386	3	thus	thus	ADV
bam-1791	386	4	represent	represent	VERB
bam-1791	386	5	a	a	DET
bam-1791	386	6	key	key	ADJ
bam-1791	386	7	player	player	NOUN
bam-1791	386	8	in	in	ADP
bam-1791	386	9	the	the	DET
bam-1791	386	10	outside	outside	NOUN
bam-1791	386	11	-	-	PUNCT
bam-1791	386	12	in	in	ADP
bam-1791	386	13	integrin	integrin	NOUN
bam-1791	386	14	signalling	signal	VERB
bam-1791	386	15	,	,	PUNCT
bam-1791	386	16	mediating	mediate	VERB
bam-1791	386	17	p38	p38	NOUN
bam-1791	386	18	/	/	SYM
bam-1791	386	19	jnk	jnk	PROPN
bam-1791	386	20	and	and	CCONJ
bam-1791	386	21	akt	akt	PROPN
bam-1791	386	22	pathways	pathway	NOUN
bam-1791	386	23	cross	cross	NOUN
bam-1791	386	24	-	-	NOUN
bam-1791	386	25	talk	talk	ADJ
bam-1791	386	26	.	.	PUNCT
bam-1791	387	1	33	33	NUM
bam-1791	387	2	.	.	PUNCT
bam-1791	388	1	the	the	DET
bam-1791	388	2	p97	p97	PROPN
bam-1791	388	3	/	/	SYM
bam-1791	388	4	vcp	vcp	PROPN
bam-1791	388	5	atpase	atpase	PROPN
bam-1791	388	6	is	be	AUX
bam-1791	388	7	critical	critical	ADJ
bam-1791	388	8	in	in	ADP
bam-1791	388	9	muscle	muscle	NOUN
bam-1791	388	10	atrophy	atrophy	NOUN
bam-1791	388	11	and	and	CCONJ
bam-1791	388	12	for	for	ADP
bam-1791	388	13	the	the	DET
bam-1791	388	14	accelerated	accelerated	ADJ
bam-1791	388	15	degradation	degradation	NOUN
bam-1791	388	16	of	of	ADP
bam-1791	388	17	most	most	ADJ
bam-1791	388	18	muscle	muscle	NOUN
bam-1791	388	19	proteins	protein	NOUN
bam-1791	388	20	rosanna	rosanna	NOUN
bam-1791	388	21	piccirillo1	piccirillo1	NOUN
bam-1791	388	22	and	and	CCONJ
bam-1791	388	23	alfred	alfred	PROPN
bam-1791	388	24	l.	l.	PROPN
bam-1791	388	25	goldberg2	goldberg2	PROPN
bam-1791	388	26	1	1	NUM
bam-1791	388	27	oncology	oncology	NOUN
bam-1791	388	28	department	department	NOUN
bam-1791	388	29	,	,	PUNCT
bam-1791	388	30	mario	mario	PROPN
bam-1791	388	31	negri	negri	PROPN
bam-1791	388	32	�	�	PROPN
bam-1791	388	33	research	research	PROPN
bam-1791	388	34	institute	institute	PROPN
bam-1791	388	35	,	,	PUNCT
bam-1791	388	36	milan	milan	PROPN
bam-1791	388	37	,	,	PUNCT
bam-1791	388	38	italy	italy	PROPN
bam-1791	388	39	2	2	NUM
bam-1791	388	40	cell	cell	NOUN
bam-1791	388	41	biology	biology	NOUN
bam-1791	388	42	department	department	NOUN
bam-1791	388	43	,	,	PUNCT
bam-1791	388	44	harvard	harvard	PROPN
bam-1791	388	45	mewdical	mewdical	PROPN
bam-1791	388	46	school	school	PROPN
bam-1791	388	47	,	,	PUNCT
bam-1791	388	48	boston	boston	PROPN
bam-1791	388	49	,	,	PUNCT
bam-1791	388	50	ma	ma	PROPN
bam-1791	388	51	the	the	DET
bam-1791	388	52	p97	p97	PROPN
bam-1791	388	53	/	/	SYM
bam-1791	388	54	vcp	vcp	PROPN
bam-1791	388	55	atpase	atpase	PROPN
bam-1791	388	56	complex	complex	NOUN
bam-1791	388	57	facilitates	facilitate	VERB
bam-1791	388	58	the	the	DET
bam-1791	388	59	extraction	extraction	NOUN
bam-1791	388	60	and	and	CCONJ
bam-1791	388	61	degradation	degradation	NOUN
bam-1791	388	62	of	of	ADP
bam-1791	388	63	ubiquitinated	ubiquitinated	ADJ
bam-1791	388	64	proteins	protein	NOUN
bam-1791	388	65	from	from	ADP
bam-1791	388	66	larger	large	ADJ
bam-1791	388	67	structures	structure	NOUN
bam-1791	388	68	.	.	PUNCT
bam-1791	389	1	we	we	PRON
bam-1791	389	2	therefore	therefore	ADV
bam-1791	389	3	studied	study	VERB
bam-1791	389	4	if	if	SCONJ
bam-1791	389	5	p97	p97	NOUN
bam-1791	389	6	participates	participate	VERB
bam-1791	389	7	to	to	ADP
bam-1791	389	8	the	the	DET
bam-1791	389	9	rapid	rapid	ADJ
bam-1791	389	10	degradation	degradation	NOUN
bam-1791	389	11	of	of	ADP
bam-1791	389	12	myofibrillar	myofibrillar	ADJ
bam-1791	389	13	proteins	protein	NOUN
bam-1791	389	14	during	during	ADP
bam-1791	389	15	muscle	muscle	NOUN
bam-1791	389	16	atrophy	atrophy	NOUN
bam-1791	389	17	.	.	PUNCT
bam-1791	390	1	electroporation	electroporation	NOUN
bam-1791	390	2	of	of	ADP
bam-1791	390	3	a	a	DET
bam-1791	390	4	dominant	dominant	ADJ
bam-1791	390	5	negative	negative	ADJ
bam-1791	390	6	p97	p97	NOUN
bam-1791	390	7	(	(	PUNCT
bam-1791	390	8	dnp97	dnp97	PROPN
bam-1791	390	9	)	)	PUNCT
bam-1791	390	10	,	,	PUNCT
bam-1791	390	11	but	but	CCONJ
bam-1791	390	12	not	not	PART
bam-1791	390	13	the	the	DET
bam-1791	390	14	wt	wt	NOUN
bam-1791	390	15	,	,	PUNCT
bam-1791	390	16	into	into	ADP
bam-1791	390	17	mouse	mouse	NOUN
bam-1791	390	18	muscle	muscle	NOUN
bam-1791	390	19	reduced	reduce	VERB
bam-1791	390	20	fiber	fiber	NOUN
bam-1791	390	21	atrophy	atrophy	NOUN
bam-1791	390	22	caused	cause	VERB
bam-1791	390	23	by	by	ADP
bam-1791	390	24	denervation	denervation	NOUN
bam-1791	390	25	and	and	CCONJ
bam-1791	390	26	food	food	NOUN
bam-1791	390	27	deprivation	deprivation	NOUN
bam-1791	390	28	.	.	PUNCT
bam-1791	391	1	dnp97	dnp97	NOUN
bam-1791	391	2	(	(	PUNCT
bam-1791	391	3	acting	act	VERB
bam-1791	391	4	as	as	ADP
bam-1791	391	5	a	a	DET
bam-1791	391	6	substrate	substrate	NOUN
bam-1791	391	7	-	-	PUNCT
bam-1791	391	8	trap	trap	NOUN
bam-1791	391	9	)	)	PUNCT
bam-1791	391	10	became	became	AUX
bam-1791	391	11	associated	associate	VERB
bam-1791	391	12	with	with	ADP
bam-1791	391	13	specific	specific	ADJ
bam-1791	391	14	myofibrillar	myofibrillar	ADJ
bam-1791	391	15	proteins	protein	NOUN
bam-1791	391	16	and	and	CCONJ
bam-1791	391	17	its	its	PRON
bam-1791	391	18	cofactors	cofactor	NOUN
bam-1791	391	19	,	,	PUNCT
bam-1791	391	20	ufd1	ufd1	NOUN
bam-1791	391	21	and	and	CCONJ
bam-1791	391	22	p47	p47	NUM
bam-1791	391	23	,	,	PUNCT
bam-1791	391	24	and	and	CCONJ
bam-1791	391	25	caused	cause	VERB
bam-1791	391	26	accumulation	accumulation	NOUN
bam-1791	391	27	of	of	ADP
bam-1791	391	28	ubiquitinated	ubiquitinated	ADJ
bam-1791	391	29	components	component	NOUN
bam-1791	391	30	of	of	ADP
bam-1791	391	31	thin	thin	ADJ
bam-1791	391	32	and	and	CCONJ
bam-1791	391	33	thick	thick	ADJ
bam-1791	391	34	filaments	filament	NOUN
bam-1791	391	35	,	,	PUNCT
bam-1791	391	36	which	which	PRON
bam-1791	391	37	suggests	suggest	VERB
bam-1791	391	38	a	a	DET
bam-1791	391	39	role	role	NOUN
bam-1791	391	40	for	for	ADP
bam-1791	391	41	p97	p97	NOUN
bam-1791	391	42	in	in	ADP
bam-1791	391	43	extracting	extract	VERB
bam-1791	391	44	ubiquitinated	ubiquitinated	ADJ
bam-1791	391	45	proteins	protein	NOUN
bam-1791	391	46	from	from	ADP
bam-1791	391	47	myofibrils	myofibril	NOUN
bam-1791	391	48	during	during	ADP
bam-1791	391	49	atrophy	atrophy	NOUN
bam-1791	391	50	.	.	PUNCT
bam-1791	392	1	dnp97	dnp97	NOUN
bam-1791	392	2	expression	expression	NOUN
bam-1791	392	3	in	in	ADP
bam-1791	392	4	myotubes	myotube	NOUN
bam-1791	392	5	reduced	reduce	VERB
bam-1791	392	6	overall	overall	ADJ
bam-1791	392	7	proteolysis	proteolysis	NOUN
bam-1791	392	8	by	by	ADP
bam-1791	392	9	proteasomes	proteasome	NOUN
bam-1791	392	10	and	and	CCONJ
bam-1791	392	11	lysosomes	lysosome	NOUN
bam-1791	392	12	and	and	CCONJ
bam-1791	392	13	blocked	block	VERB
bam-1791	392	14	the	the	DET
bam-1791	392	15	accelerated	accelerate	VERB
bam-1791	392	16	proteolysis	proteolysis	NOUN
bam-1791	392	17	induced	induce	VERB
bam-1791	392	18	by	by	ADP
bam-1791	392	19	foxo3	foxo3	PROPN
bam-1791	392	20	,	,	PUNCT
bam-1791	392	21	which	which	PRON
bam-1791	392	22	is	be	AUX
bam-1791	392	23	essential	essential	ADJ
bam-1791	392	24	for	for	ADP
bam-1791	392	25	atrophy	atrophy	NOUN
bam-1791	392	26	.	.	PUNCT
bam-1791	393	1	expression	expression	NOUN
bam-1791	393	2	of	of	ADP
bam-1791	393	3	p97	p97	NOUN
bam-1791	393	4	,	,	PUNCT
bam-1791	393	5	ufd1	ufd1	PROPN
bam-1791	393	6	and	and	CCONJ
bam-1791	393	7	p47	p47	NOUN
bam-1791	393	8	increases	increase	NOUN
bam-1791	393	9	following	follow	VERB
bam-1791	393	10	denervation	denervation	NOUN
bam-1791	393	11	,	,	PUNCT
bam-1791	393	12	at	at	ADP
bam-1791	393	13	times	time	NOUN
bam-1791	393	14	when	when	SCONJ
bam-1791	393	15	myofibrils	myofibril	NOUN
bam-1791	393	16	are	be	AUX
bam-1791	393	17	rapidly	rapidly	ADV
bam-1791	393	18	degraded	degrade	VERB
bam-1791	393	19	.	.	PUNCT
bam-1791	394	1	surprisingly	surprisingly	ADV
bam-1791	394	2	,	,	PUNCT
bam-1791	394	3	p97	p97	NOUN
bam-1791	394	4	inhibition	inhibition	NOUN
bam-1791	394	5	,	,	PUNCT
bam-1791	394	6	though	though	SCONJ
bam-1791	394	7	toxic	toxic	ADJ
bam-1791	394	8	to	to	ADP
bam-1791	394	9	most	most	ADJ
bam-1791	394	10	cells	cell	NOUN
bam-1791	394	11	,	,	PUNCT
bam-1791	394	12	caused	cause	VERB
bam-1791	394	13	rapid	rapid	ADJ
bam-1791	394	14	growth	growth	NOUN
bam-1791	394	15	of	of	ADP
bam-1791	394	16	myotubes	myotube	NOUN
bam-1791	394	17	(	(	PUNCT
bam-1791	394	18	without	without	ADP
bam-1791	394	19	enhancing	enhance	VERB
bam-1791	394	20	protein	protein	NOUN
bam-1791	394	21	synthesis	synthesis	NOUN
bam-1791	394	22	)	)	PUNCT
bam-1791	394	23	and	and	CCONJ
bam-1791	394	24	hypertrophy	hypertrophy	NOUN
bam-1791	394	25	of	of	ADP
bam-1791	394	26	adult	adult	NOUN
bam-1791	394	27	muscles	muscle	NOUN
bam-1791	394	28	.	.	PUNCT
bam-1791	395	1	thus	thus	ADV
bam-1791	395	2	,	,	PUNCT
bam-1791	395	3	p97	p97	NOUN
bam-1791	395	4	restrains	restrain	VERB
bam-1791	395	5	post	post	ADJ
bam-1791	395	6	-	-	ADJ
bam-1791	395	7	natal	natal	ADJ
bam-1791	395	8	muscle	muscle	NOUN
bam-1791	395	9	growth	growth	NOUN
bam-1791	395	10	,	,	PUNCT
bam-1791	395	11	and	and	CCONJ
bam-1791	395	12	during	during	ADP
bam-1791	395	13	atrophy	atrophy	NOUN
bam-1791	395	14	,	,	PUNCT
bam-1791	395	15	is	be	AUX
bam-1791	395	16	essential	essential	ADJ
bam-1791	395	17	for	for	ADP
bam-1791	395	18	the	the	DET
bam-1791	395	19	accelerated	accelerated	ADJ
bam-1791	395	20	degradation	degradation	NOUN
bam-1791	395	21	of	of	ADP
bam-1791	395	22	most	most	ADJ
bam-1791	395	23	muscle	muscle	NOUN
bam-1791	395	24	proteins	protein	NOUN
bam-1791	395	25	.	.	PUNCT
bam-1791	396	1	34	34	NUM
bam-1791	396	2	.	.	PUNCT
bam-1791	396	3	intracellular	intracellular	NOUN
bam-1791	396	4	signaling	signal	VERB
bam-1791	396	5	in	in	ADP
bam-1791	396	6	er	er	ADJ
bam-1791	396	7	-	-	PUNCT
bam-1791	396	8	stress	stress	NOUN
bam-1791	396	9	induced	induce	VERB
bam-1791	396	10	autophagy	autophagy	ADV
bam-1791	396	11	in	in	ADP
bam-1791	396	12	skeletal	skeletal	ADJ
bam-1791	396	13	muscle	muscle	NOUN
bam-1791	396	14	cells	cell	NOUN
bam-1791	396	15	.	.	PUNCT
bam-1791	397	1	luca	luca	PROPN
bam-1791	397	2	madaro1	madaro1	PROPN
bam-1791	397	3	,	,	PUNCT
bam-1791	397	4	valeria	valeria	PROPN
bam-1791	397	5	marrocco1	marrocco1	PROPN
bam-1791	397	6	,	,	PUNCT
bam-1791	397	7	silvia	silvia	PROPN
bam-1791	397	8	carnio2	carnio2	PROPN
bam-1791	397	9	,	,	PUNCT
bam-1791	397	10	marco	marco	PROPN
bam-1791	397	11	sandri2,3	sandri2,3	PROPN
bam-1791	397	12	and	and	CCONJ
bam-1791	397	13	marina	marina	NOUN
bam-1791	397	14	bouché1	bouché1	PROPN
bam-1791	397	15	,	,	PUNCT
bam-1791	397	16	*	*	PROPN
bam-1791	397	17	1dahfmo	1dahfmo	NUM
bam-1791	397	18	,	,	PUNCT
bam-1791	397	19	unit	unit	NOUN
bam-1791	397	20	of	of	ADP
bam-1791	397	21	histology	histology	NOUN
bam-1791	397	22	,	,	PUNCT
bam-1791	397	23	and	and	CCONJ
bam-1791	397	24	iim	iim	PROPN
bam-1791	397	25	,	,	PUNCT
bam-1791	397	26	sapienza	sapienza	PROPN
bam-1791	397	27	university	university	PROPN
bam-1791	397	28	of	of	ADP
bam-1791	397	29	rome	rome	PROPN
bam-1791	397	30	,	,	PUNCT
bam-1791	397	31	00161	00161	NUM
bam-1791	397	32	rome	rome	PROPN
bam-1791	397	33	,	,	PUNCT
bam-1791	397	34	italy	italy	PROPN
bam-1791	397	35	,	,	PUNCT
bam-1791	397	36	2	2	NUM
bam-1791	397	37	dulbecco	dulbecco	NOUN
bam-1791	397	38	telethon	telethon	PROPN
bam-1791	397	39	institute	institute	NOUN
bam-1791	397	40	at	at	ADP
bam-1791	397	41	venetian	venetian	PROPN
bam-1791	397	42	institute	institute	NOUN
bam-1791	397	43	of	of	ADP
bam-1791	397	44	molecular	molecular	ADJ
bam-1791	397	45	medicine	medicine	NOUN
bam-1791	397	46	,	,	PUNCT
bam-1791	397	47	35129	35129	NUM
bam-1791	397	48	padova	padova	PROPN
bam-1791	397	49	,	,	PUNCT
bam-1791	397	50	italy	italy	PROPN
bam-1791	397	51	and	and	CCONJ
bam-1791	397	52	3	3	NUM
bam-1791	397	53	department	department	NOUN
bam-1791	397	54	of	of	ADP
bam-1791	397	55	biomedical	biomedical	ADJ
bam-1791	397	56	science	science	NOUN
bam-1791	397	57	,	,	PUNCT
bam-1791	397	58	university	university	NOUN
bam-1791	397	59	of	of	ADP
bam-1791	397	60	padova	padova	PROPN
bam-1791	397	61	,	,	PUNCT
bam-1791	397	62	35129	35129	NUM
bam-1791	397	63	padova	padova	PROPN
bam-1791	397	64	,	,	PUNCT
bam-1791	397	65	italy	italy	PROPN
bam-1791	397	66	.	.	PUNCT
bam-1791	398	1	skeletal	skeletal	ADJ
bam-1791	398	2	muscle	muscle	NOUN
bam-1791	398	3	remodelling	remodelling	NOUN
bam-1791	398	4	in	in	ADP
bam-1791	398	5	response	response	NOUN
bam-1791	398	6	to	to	ADP
bam-1791	398	7	muscle	muscle	NOUN
bam-1791	398	8	disuse	disuse	NOUN
bam-1791	398	9	and	and	CCONJ
bam-1791	398	10	unloading	unloading	NOUN
bam-1791	398	11	is	be	AUX
bam-1791	398	12	known	know	VERB
bam-1791	398	13	to	to	PART
bam-1791	398	14	be	be	AUX
bam-1791	398	15	associated	associate	VERB
bam-1791	398	16	to	to	ADP
bam-1791	398	17	the	the	DET
bam-1791	398	18	so	so	ADV
bam-1791	398	19	-	-	PUNCT
bam-1791	398	20	called	call	VERB
bam-1791	398	21	erstress	erstress	NOUN
bam-1791	398	22	,	,	PUNCT
bam-1791	398	23	which	which	PRON
bam-1791	398	24	in	in	ADP
bam-1791	398	25	turn	turn	NOUN
bam-1791	398	26	activates	activate	VERB
bam-1791	398	27	autophagy	autophagy	ADV
bam-1791	398	28	and	and	CCONJ
bam-1791	398	29	contributes	contribute	VERB
bam-1791	398	30	to	to	ADP
bam-1791	398	31	muscle	muscle	NOUN
bam-1791	398	32	atrophy	atrophy	NOUN
bam-1791	398	33	.	.	PUNCT
bam-1791	399	1	different	different	ADJ
bam-1791	399	2	molecules	molecule	NOUN
bam-1791	399	3	are	be	AUX
bam-1791	399	4	involved	involve	VERB
bam-1791	399	5	in	in	ADP
bam-1791	399	6	erstress	erstress	NOUN
bam-1791	399	7	induced	induce	VERB
bam-1791	399	8	autophagy	autophagy	VERB
bam-1791	399	9	,	,	PUNCT
bam-1791	399	10	among	among	ADP
bam-1791	399	11	which	which	PRON
bam-1791	399	12	pkcθ	pkcθ	NOUN
bam-1791	399	13	has	have	AUX
bam-1791	399	14	been	be	AUX
bam-1791	399	15	recently	recently	ADV
bam-1791	399	16	described	describe	VERB
bam-1791	399	17	.	.	PUNCT
bam-1791	400	1	in	in	ADP
bam-1791	400	2	this	this	DET
bam-1791	400	3	study	study	NOUN
bam-1791	400	4	we	we	PRON
bam-1791	400	5	dissected	dissect	VERB
bam-1791	400	6	both	both	CCONJ
bam-1791	400	7	in	in	ADP
bam-1791	400	8	vitro	vitro	X
bam-1791	400	9	and	and	CCONJ
bam-1791	400	10	in	in	ADP
bam-1791	400	11	vivo	vivo	ADJ
bam-1791	400	12	er	er	INTJ
bam-1791	400	13	-	-	PUNCT
bam-1791	400	14	stress	stress	NOUN
bam-1791	400	15	induced	induce	VERB
bam-1791	400	16	autophagy	autophagy	ADJ
bam-1791	400	17	pathways	pathway	NOUN
bam-1791	400	18	in	in	ADP
bam-1791	400	19	muscle	muscle	NOUN
bam-1791	400	20	.	.	PUNCT
bam-1791	401	1	we	we	PRON
bam-1791	401	2	demonstrated	demonstrate	VERB
bam-1791	401	3	that	that	SCONJ
bam-1791	401	4	pkcθ	pkcθ	NOUN
bam-1791	401	5	is	be	AUX
bam-1791	401	6	strongly	strongly	ADV
bam-1791	401	7	activated	activate	VERB
bam-1791	401	8	in	in	ADP
bam-1791	401	9	cultured	cultured	ADJ
bam-1791	401	10	ix	ix	ADP
bam-1791	401	11	iim	iim	PROPN
bam-1791	401	12	meeting	meeting	NOUN
bam-1791	401	13	,	,	PUNCT
bam-1791	401	14	acaya	acaya	NOUN
bam-1791	401	15	(	(	PUNCT
bam-1791	401	16	lecce	lecce	PROPN
bam-1791	401	17	)	)	PUNCT
bam-1791	401	18	,	,	PUNCT
bam-1791	401	19	october	october	PROPN
bam-1791	401	20	12	12	NUM
bam-1791	401	21	-	-	SYM
bam-1791	401	22	14	14	NUM
bam-1791	401	23	,	,	PUNCT
bam-1791	401	24	2012	2012	NUM
bam-1791	401	25	european	european	PROPN
bam-1791	401	26	journal	journal	PROPN
bam-1791	401	27	translational	translational	ADJ
bam-1791	401	28	myology	myology	NOUN
bam-1791	401	29	basic	basic	ADJ
bam-1791	401	30	applied	apply	VERB
bam-1791	401	31	myology	myology	NOUN
bam-1791	401	32	2012	2012	NUM
bam-1791	401	33	;	;	PUNCT
bam-1791	401	34	22(1&2	22(1&2	NUM
bam-1791	401	35	):	):	PUNCT
bam-1791	401	36	xxx	xxx	NOUN
bam-1791	401	37	-	-	PUNCT
bam-1791	401	38	xxx	xxx	NOUN
bam-1791	401	39	35	35	NUM
bam-1791	401	40	myoblasts	myoblast	NOUN
bam-1791	401	41	during	during	ADP
bam-1791	401	42	er	er	ADJ
bam-1791	401	43	-	-	PUNCT
bam-1791	401	44	stress	stress	NOUN
bam-1791	401	45	induced	induce	VERB
bam-1791	401	46	by	by	ADP
bam-1791	401	47	different	different	ADJ
bam-1791	401	48	stimuli	stimulus	NOUN
bam-1791	401	49	,	,	PUNCT
bam-1791	401	50	such	such	ADJ
bam-1791	401	51	as	as	ADP
bam-1791	401	52	tg	tg	PROPN
bam-1791	401	53	or	or	CCONJ
bam-1791	401	54	tn	tn	NOUN
bam-1791	401	55	treatment	treatment	NOUN
bam-1791	401	56	,	,	PUNCT
bam-1791	401	57	and	and	CCONJ
bam-1791	401	58	it	it	PRON
bam-1791	401	59	localizes	localize	VERB
bam-1791	401	60	into	into	ADP
bam-1791	401	61	lc3	lc3	NOUN
bam-1791	401	62	positive	positive	ADJ
bam-1791	401	63	autophagic	autophagic	ADJ
bam-1791	401	64	dots	dot	NOUN
bam-1791	401	65	.	.	PUNCT
bam-1791	402	1	no	no	DET
bam-1791	402	2	akt	akt	PROPN
bam-1791	402	3	de	de	PROPN
bam-1791	402	4	-	-	NOUN
bam-1791	402	5	phosphorylation	phosphorylation	NOUN
bam-1791	402	6	,	,	PUNCT
bam-1791	402	7	nor	nor	CCONJ
bam-1791	402	8	foxo3a	foxo3a	VERB
bam-1791	402	9	or	or	CCONJ
bam-1791	402	10	gsk3β	gsk3β	PROPN
bam-1791	402	11	activation	activation	NOUN
bam-1791	402	12	were	be	AUX
bam-1791	402	13	observed	observe	VERB
bam-1791	402	14	in	in	ADP
bam-1791	402	15	these	these	DET
bam-1791	402	16	conditions	condition	NOUN
bam-1791	402	17	.	.	PUNCT
bam-1791	403	1	moreover	moreover	ADV
bam-1791	403	2	,	,	PUNCT
bam-1791	403	3	pkcθ	pkcθ	ADJ
bam-1791	403	4	inhibition	inhibition	NOUN
bam-1791	403	5	and/or	and/or	CCONJ
bam-1791	403	6	lack	lack	NOUN
bam-1791	403	7	in	in	ADP
bam-1791	403	8	myoblasts	myoblast	NOUN
bam-1791	403	9	prevented	prevent	VERB
bam-1791	403	10	er	er	INTJ
bam-1791	403	11	-	-	PUNCT
bam-1791	403	12	stress	stress	NOUN
bam-1791	403	13	-	-	PUNCT
bam-1791	403	14	induced	induce	VERB
bam-1791	403	15	lc3	lc3	NOUN
bam-1791	403	16	activation	activation	NOUN
bam-1791	403	17	and	and	CCONJ
bam-1791	403	18	autophagic	autophagic	NOUN
bam-1791	403	19	dots	dot	NOUN
bam-1791	403	20	formation	formation	NOUN
bam-1791	403	21	,	,	PUNCT
bam-1791	403	22	while	while	SCONJ
bam-1791	403	23	its	its	PRON
bam-1791	403	24	activation	activation	NOUN
bam-1791	403	25	resulted	result	VERB
bam-1791	403	26	in	in	ADP
bam-1791	403	27	lc3	lc3	NOUN
bam-1791	403	28	activation	activation	NOUN
bam-1791	403	29	in	in	ADP
bam-1791	403	30	the	the	DET
bam-1791	403	31	absence	absence	NOUN
bam-1791	403	32	of	of	ADP
bam-1791	403	33	er	er	INTJ
bam-1791	403	34	-	-	PUNCT
bam-1791	403	35	stress	stress	NOUN
bam-1791	403	36	.	.	PUNCT
bam-1791	404	1	in	in	ADP
bam-1791	404	2	vivo	vivo	NOUN
bam-1791	404	3	,	,	PUNCT
bam-1791	404	4	lack	lack	NOUN
bam-1791	404	5	of	of	ADP
bam-1791	404	6	pkcθ	pkcθ	NOUN
bam-1791	404	7	prevented	prevent	VERB
bam-1791	404	8	both	both	CCONJ
bam-1791	404	9	fasting	fast	VERB
bam-1791	404	10	-	-	PUNCT
bam-1791	404	11	and	and	CCONJ
bam-1791	404	12	immobilization	immobilization	NOUN
bam-1791	404	13	-	-	PUNCT
bam-1791	404	14	induced	induce	VERB
bam-1791	404	15	autophagy	autophagy	NOUN
bam-1791	404	16	and	and	CCONJ
bam-1791	404	17	muscle	muscle	NOUN
bam-1791	404	18	atrophy	atrophy	NOUN
bam-1791	404	19	,	,	PUNCT
bam-1791	404	20	irrespective	irrespective	ADV
bam-1791	404	21	of	of	ADP
bam-1791	404	22	akt	akt	PROPN
bam-1791	404	23	pathway	pathway	NOUN
bam-1791	404	24	inhibition	inhibition	NOUN
bam-1791	404	25	.	.	PUNCT
bam-1791	405	1	taken	take	VERB
bam-1791	405	2	together	together	ADV
bam-1791	405	3	these	these	DET
bam-1791	405	4	results	result	NOUN
bam-1791	405	5	demonstrate	demonstrate	VERB
bam-1791	405	6	that	that	SCONJ
bam-1791	405	7	pkcθ	pkcθ	PROPN
bam-1791	405	8	works	work	VERB
bam-1791	405	9	as	as	ADP
bam-1791	405	10	an	an	DET
bam-1791	405	11	er	er	INTJ
bam-1791	405	12	-	-	PUNCT
bam-1791	405	13	stress	stress	NOUN
bam-1791	405	14	sensor	sensor	NOUN
bam-1791	405	15	in	in	ADP
bam-1791	405	16	skeletal	skeletal	ADJ
bam-1791	405	17	muscle	muscle	NOUN
bam-1791	405	18	,	,	PUNCT
bam-1791	405	19	required	require	VERB
bam-1791	405	20	for	for	ADP
bam-1791	405	21	autophagy	autophagy	ADJ
bam-1791	405	22	activation	activation	NOUN
bam-1791	405	23	,	,	PUNCT
bam-1791	405	24	and	and	CCONJ
bam-1791	405	25	can	can	AUX
bam-1791	405	26	be	be	AUX
bam-1791	405	27	proposed	propose	VERB
bam-1791	405	28	as	as	ADP
bam-1791	405	29	a	a	DET
bam-1791	405	30	novel	novel	ADJ
bam-1791	405	31	molecular	molecular	ADJ
bam-1791	405	32	target	target	NOUN
bam-1791	405	33	to	to	PART
bam-1791	405	34	maintain	maintain	VERB
bam-1791	405	35	muscle	muscle	NOUN
bam-1791	405	36	homeostasis	homeostasis	NOUN
bam-1791	405	37	in	in	ADP
bam-1791	405	38	response	response	NOUN
bam-1791	405	39	to	to	ADP
bam-1791	405	40	external	external	ADJ
bam-1791	405	41	stimuli	stimulus	NOUN
bam-1791	405	42	,	,	PUNCT
bam-1791	405	43	such	such	ADJ
bam-1791	405	44	as	as	ADP
bam-1791	405	45	disuse	disuse	NOUN
bam-1791	405	46	and	and	CCONJ
bam-1791	405	47	unloading	unloading	NOUN
bam-1791	405	48	,	,	PUNCT
bam-1791	405	49	still	still	ADV
bam-1791	405	50	allowing	allow	VERB
bam-1791	405	51	intracellular	intracellular	ADJ
bam-1791	405	52	clearance	clearance	NOUN
bam-1791	405	53	.	.	PUNCT
bam-1791	406	1	35	35	NUM
bam-1791	406	2	.	.	PUNCT
bam-1791	406	3	study	study	NOUN
bam-1791	406	4	of	of	ADP
bam-1791	406	5	the	the	DET
bam-1791	406	6	role	role	NOUN
bam-1791	406	7	of	of	ADP
bam-1791	406	8	the	the	DET
bam-1791	406	9	transcription	transcription	NOUN
bam-1791	406	10	factor	factor	NOUN
bam-1791	406	11	foxo1	foxo1	NOUN
bam-1791	406	12	in	in	ADP
bam-1791	406	13	skeletal	skeletal	ADJ
bam-1791	406	14	muscle	muscle	NOUN
bam-1791	406	15	during	during	ADP
bam-1791	406	16	muscle	muscle	NOUN
bam-1791	406	17	atrophy	atrophy	NOUN
bam-1791	406	18	francesca	francesca	PROPN
bam-1791	406	19	pescatore	pescatore	PROPN
bam-1791	406	20	1	1	NUM
bam-1791	406	21	,	,	PUNCT
bam-1791	406	22	vanina	vanina	NOUN
bam-1791	406	23	romanello	romanello	ADJ
bam-1791	406	24	2	2	NUM
bam-1791	406	25	,	,	PUNCT
bam-1791	406	26	giulia	giulia	PROPN
bam-1791	406	27	milan	milan	PROPN
bam-1791	406	28	1	1	NUM
bam-1791	406	29	,	,	PUNCT
bam-1791	406	30	anke	anke	PROPN
bam-1791	406	31	seydel	seydel	PROPN
bam-1791	406	32	1,laura	1,laura	NUM
bam-1791	406	33	frasson	frasson	PROPN
bam-1791	406	34	1	1	NUM
bam-1791	406	35	,	,	PUNCT
bam-1791	406	36	marco	marco	PROPN
bam-1791	406	37	sandri	sandri	VERB
bam-1791	406	38	1,2,3	1,2,3	NUM
bam-1791	406	39	1	1	NUM
bam-1791	406	40	venetian	venetian	ADJ
bam-1791	406	41	institute	institute	NOUN
bam-1791	406	42	of	of	ADP
bam-1791	406	43	molecular	molecular	ADJ
bam-1791	406	44	medicine	medicine	NOUN
bam-1791	406	45	(	(	PUNCT
bam-1791	406	46	vimm	vimm	PROPN
bam-1791	406	47	)	)	PUNCT
bam-1791	406	48	,	,	PUNCT
bam-1791	406	49	padova	padova	PROPN
bam-1791	406	50	,	,	PUNCT
bam-1791	406	51	italy	italy	PROPN
bam-1791	406	52	dulbecco	dulbecco	VERB
bam-1791	406	53	telethon	telethon	PROPN
bam-1791	406	54	institute	institute	NOUN
bam-1791	406	55	at	at	ADP
bam-1791	406	56	venetian	venetian	PROPN
bam-1791	406	57	institute	institute	NOUN
bam-1791	406	58	of	of	ADP
bam-1791	406	59	molecular	molecular	ADJ
bam-1791	406	60	medicine	medicine	NOUN
bam-1791	406	61	,	,	PUNCT
bam-1791	406	62	via	via	ADP
bam-1791	406	63	orus	orus	NOUN
bam-1791	406	64	2	2	NUM
bam-1791	406	65	,	,	PUNCT
bam-1791	406	66	35129	35129	NUM
bam-1791	406	67	padova	padova	PROPN
bam-1791	406	68	,	,	PUNCT
bam-1791	406	69	italy	italy	PROPN
bam-1791	406	70	.	.	PROPN
bam-1791	407	1	3	3	NUM
bam-1791	407	2	department	department	NOUN
bam-1791	407	3	of	of	ADP
bam-1791	407	4	biomedical	biomedical	ADJ
bam-1791	407	5	science	science	NOUN
bam-1791	407	6	,	,	PUNCT
bam-1791	407	7	university	university	NOUN
bam-1791	407	8	of	of	ADP
bam-1791	407	9	padova	padova	PROPN
bam-1791	407	10	,	,	PUNCT
bam-1791	407	11	via	via	ADP
bam-1791	407	12	g.	g.	PROPN
bam-1791	407	13	colombo	colombo	PROPN
bam-1791	407	14	3	3	NUM
bam-1791	407	15	,	,	PUNCT
bam-1791	407	16	35100	35100	NUM
bam-1791	407	17	padova	padova	PROPN
bam-1791	407	18	,	,	PUNCT
bam-1791	407	19	italy	italy	PROPN
bam-1791	407	20	skeletal	skeletal	ADJ
bam-1791	407	21	muscle	muscle	NOUN
bam-1791	407	22	atrophy	atrophy	NOUN
bam-1791	407	23	is	be	AUX
bam-1791	407	24	a	a	DET
bam-1791	407	25	debilitating	debilitate	VERB
bam-1791	407	26	consequence	consequence	NOUN
bam-1791	407	27	of	of	ADP
bam-1791	407	28	fasting	fasting	NOUN
bam-1791	407	29	,	,	PUNCT
bam-1791	407	30	denervation	denervation	NOUN
bam-1791	407	31	,	,	PUNCT
bam-1791	407	32	cancer	cancer	NOUN
bam-1791	407	33	and	and	CCONJ
bam-1791	407	34	other	other	ADJ
bam-1791	407	35	systemic	systemic	ADJ
bam-1791	407	36	diseases	disease	NOUN
bam-1791	407	37	.	.	PUNCT
bam-1791	408	1	these	these	DET
bam-1791	408	2	different	different	ADJ
bam-1791	408	3	conditions	condition	NOUN
bam-1791	408	4	have	have	VERB
bam-1791	408	5	in	in	ADP
bam-1791	408	6	common	common	ADJ
bam-1791	408	7	an	an	DET
bam-1791	408	8	increased	increase	VERB
bam-1791	408	9	activation	activation	NOUN
bam-1791	408	10	of	of	ADP
bam-1791	408	11	protein	protein	NOUN
bam-1791	408	12	degradation	degradation	NOUN
bam-1791	408	13	systems	system	NOUN
bam-1791	408	14	.	.	PUNCT
bam-1791	409	1	foxo	foxo	ADJ
bam-1791	409	2	transcription	transcription	NOUN
bam-1791	409	3	factors	factor	NOUN
bam-1791	409	4	are	be	AUX
bam-1791	409	5	key	key	ADJ
bam-1791	409	6	regulators	regulator	NOUN
bam-1791	409	7	that	that	PRON
bam-1791	409	8	play	play	VERB
bam-1791	409	9	a	a	DET
bam-1791	409	10	critical	critical	ADJ
bam-1791	409	11	role	role	NOUN
bam-1791	409	12	in	in	ADP
bam-1791	409	13	the	the	DET
bam-1791	409	14	atrophy	atrophy	NOUN
bam-1791	409	15	program	program	NOUN
bam-1791	409	16	being	be	AUX
bam-1791	409	17	sufficient	sufficient	ADJ
bam-1791	409	18	and	and	CCONJ
bam-1791	409	19	necessary	necessary	ADJ
bam-1791	409	20	for	for	ADP
bam-1791	409	21	the	the	DET
bam-1791	409	22	expression	expression	NOUN
bam-1791	409	23	of	of	ADP
bam-1791	409	24	genes	gene	NOUN
bam-1791	409	25	belonging	belong	VERB
bam-1791	409	26	to	to	ADP
bam-1791	409	27	both	both	CCONJ
bam-1791	409	28	proteolytic	proteolytic	ADJ
bam-1791	409	29	pathways	pathway	NOUN
bam-1791	409	30	,	,	PUNCT
bam-1791	409	31	the	the	DET
bam-1791	409	32	ubiquitin	ubiquitin	NOUN
bam-1791	409	33	-	-	PUNCT
bam-1791	409	34	proteasome	proteasome	NOUN
bam-1791	409	35	and	and	CCONJ
bam-1791	409	36	the	the	DET
bam-1791	409	37	autophagy	autophagy	ADJ
bam-1791	409	38	-	-	PUNCT
bam-1791	409	39	lysosome	lysosome	NOUN
bam-1791	409	40	systems	system	NOUN
bam-1791	409	41	.	.	PUNCT
bam-1791	410	1	in	in	ADP
bam-1791	410	2	skeletal	skeletal	ADJ
bam-1791	410	3	muscle	muscle	NOUN
bam-1791	410	4	,	,	PUNCT
bam-1791	410	5	the	the	DET
bam-1791	410	6	foxo	foxo	ADJ
bam-1791	410	7	family	family	NOUN
bam-1791	410	8	is	be	AUX
bam-1791	410	9	comprised	comprise	VERB
bam-1791	410	10	of	of	ADP
bam-1791	410	11	three	three	NUM
bam-1791	410	12	isoforms	isoform	NOUN
bam-1791	410	13	:	:	PUNCT
bam-1791	410	14	foxo1	foxo1	PROPN
bam-1791	410	15	,	,	PUNCT
bam-1791	410	16	foxo3	foxo3	PROPN
bam-1791	410	17	and	and	CCONJ
bam-1791	410	18	foxo4.to	foxo4.to	PRON
bam-1791	410	19	investigate	investigate	VERB
bam-1791	410	20	the	the	DET
bam-1791	410	21	role	role	NOUN
bam-1791	410	22	of	of	ADP
bam-1791	410	23	foxo1	foxo1	NOUN
bam-1791	410	24	in	in	ADP
bam-1791	410	25	skeletal	skeletal	ADJ
bam-1791	410	26	muscle	muscle	NOUN
bam-1791	410	27	,	,	PUNCT
bam-1791	410	28	we	we	PRON
bam-1791	410	29	generated	generate	VERB
bam-1791	410	30	two	two	NUM
bam-1791	410	31	muscle	muscle	NOUN
bam-1791	410	32	specific	specific	ADJ
bam-1791	410	33	knock	knock	NOUN
bam-1791	410	34	-	-	PUNCT
bam-1791	410	35	out	out	ADP
bam-1791	410	36	mice	mouse	NOUN
bam-1791	410	37	:	:	PUNCT
bam-1791	410	38	a	a	DET
bam-1791	410	39	myosin	myosin	NOUN
bam-1791	410	40	light	light	NOUN
bam-1791	410	41	chain	chain	NOUN
bam-1791	410	42	1	1	NUM
bam-1791	410	43	(	(	PUNCT
bam-1791	410	44	mlc1)-driven	mlc1)-driven	NOUN
bam-1791	410	45	constitutive	constitutive	ADJ
bam-1791	410	46	animal	animal	NOUN
bam-1791	410	47	and	and	CCONJ
bam-1791	410	48	tamoxifen	tamoxifen	NOUN
bam-1791	410	49	-	-	PUNCT
bam-1791	410	50	inducible	inducible	ADJ
bam-1791	410	51	mice	mouse	NOUN
bam-1791	410	52	.	.	PUNCT
bam-1791	411	1	knock	knock	VERB
bam-1791	411	2	-	-	PUNCT
bam-1791	411	3	out	out	ADP
bam-1791	411	4	animals	animal	NOUN
bam-1791	411	5	are	be	AUX
bam-1791	411	6	fully	fully	ADV
bam-1791	411	7	viable	viable	ADJ
bam-1791	411	8	,	,	PUNCT
bam-1791	411	9	fertile	fertile	ADJ
bam-1791	411	10	and	and	CCONJ
bam-1791	411	11	phenotypically	phenotypically	ADV
bam-1791	411	12	normal	normal	ADJ
bam-1791	411	13	and	and	CCONJ
bam-1791	411	14	indistinguishable	indistinguishable	ADJ
bam-1791	411	15	in	in	ADP
bam-1791	411	16	appearance	appearance	NOUN
bam-1791	411	17	from	from	ADP
bam-1791	411	18	wild	wild	ADJ
bam-1791	411	19	type	type	NOUN
bam-1791	411	20	litter	litter	NOUN
bam-1791	411	21	mates	mate	NOUN
bam-1791	411	22	.	.	PUNCT
bam-1791	412	1	in	in	ADP
bam-1791	412	2	this	this	DET
bam-1791	412	3	study	study	NOUN
bam-1791	412	4	,	,	PUNCT
bam-1791	412	5	we	we	PRON
bam-1791	412	6	want	want	VERB
bam-1791	412	7	to	to	PART
bam-1791	412	8	understand	understand	VERB
bam-1791	412	9	which	which	PRON
bam-1791	412	10	are	be	AUX
bam-1791	412	11	the	the	DET
bam-1791	412	12	atrophy	atrophy	NOUN
bam-1791	412	13	-	-	PUNCT
bam-1791	412	14	related	relate	VERB
bam-1791	412	15	genes	gene	NOUN
bam-1791	412	16	specifically	specifically	ADV
bam-1791	412	17	under	under	ADP
bam-1791	412	18	the	the	DET
bam-1791	412	19	control	control	NOUN
bam-1791	412	20	of	of	ADP
bam-1791	412	21	foxo1	foxo1	NOUN
bam-1791	412	22	during	during	ADP
bam-1791	412	23	denervation	denervation	NOUN
bam-1791	412	24	.	.	PUNCT
bam-1791	413	1	indeed	indeed	ADV
bam-1791	413	2	,	,	PUNCT
bam-1791	413	3	only	only	ADV
bam-1791	413	4	a	a	DET
bam-1791	413	5	subset	subset	NOUN
bam-1791	413	6	of	of	ADP
bam-1791	413	7	the	the	DET
bam-1791	413	8	atrophy	atrophy	NOUN
bam-1791	413	9	-	-	PUNCT
bam-1791	413	10	related	relate	VERB
bam-1791	413	11	genes	gene	NOUN
bam-1791	413	12	are	be	AUX
bam-1791	413	13	under	under	ADP
bam-1791	413	14	foxo1	foxo1	PROPN
bam-1791	413	15	control	control	PROPN
bam-1791	413	16	.	.	PUNCT
bam-1791	414	1	importantly	importantly	ADV
bam-1791	414	2	,	,	PUNCT
bam-1791	414	3	foxo1	foxo1	ADP
bam-1791	414	4	loss	loss	NOUN
bam-1791	414	5	is	be	AUX
bam-1791	414	6	not	not	PART
bam-1791	414	7	sufficient	sufficient	ADJ
bam-1791	414	8	to	to	PART
bam-1791	414	9	protect	protect	VERB
bam-1791	414	10	from	from	ADP
bam-1791	414	11	muscle	muscle	NOUN
bam-1791	414	12	atrophy	atrophy	NOUN
bam-1791	414	13	after	after	ADP
bam-1791	414	14	14	14	NUM
bam-1791	414	15	days	day	NOUN
bam-1791	414	16	of	of	ADP
bam-1791	414	17	denervation	denervation	NOUN
bam-1791	414	18	.	.	PUNCT
bam-1791	415	1	the	the	DET
bam-1791	415	2	study	study	NOUN
bam-1791	415	3	of	of	ADP
bam-1791	415	4	the	the	DET
bam-1791	415	5	intracellullar	intracellullar	ADJ
bam-1791	415	6	signaling	signal	VERB
bam-1791	415	7	pathways	pathway	NOUN
bam-1791	415	8	indicate	indicate	VERB
bam-1791	415	9	that	that	SCONJ
bam-1791	415	10	the	the	DET
bam-1791	415	11	foxo1	foxo1	NOUN
bam-1791	415	12	is	be	AUX
bam-1791	415	13	required	require	VERB
bam-1791	415	14	for	for	ADP
bam-1791	415	15	the	the	DET
bam-1791	415	16	igf	igf	PROPN
bam-1791	415	17	-	-	ADJ
bam-1791	415	18	pi3k	pi3k	PROPN
bam-1791	415	19	akt	akt	PROPN
bam-1791	415	20	pathway	pathway	NOUN
bam-1791	415	21	but	but	CCONJ
bam-1791	415	22	not	not	PART
bam-1791	415	23	for	for	ADP
bam-1791	415	24	mtor	mtor	NOUN
bam-1791	415	25	signaling	signal	VERB
bam-1791	415	26	.	.	PUNCT
bam-1791	416	1	in	in	ADP
bam-1791	416	2	conclusion	conclusion	NOUN
bam-1791	416	3	,	,	PUNCT
bam-1791	416	4	these	these	DET
bam-1791	416	5	findings	finding	NOUN
bam-1791	416	6	are	be	AUX
bam-1791	416	7	valuable	valuable	ADJ
bam-1791	416	8	in	in	ADP
bam-1791	416	9	order	order	NOUN
bam-1791	416	10	to	to	PART
bam-1791	416	11	develop	develop	VERB
bam-1791	416	12	new	new	ADJ
bam-1791	416	13	methods	method	NOUN
bam-1791	416	14	for	for	ADP
bam-1791	416	15	the	the	DET
bam-1791	416	16	prevention	prevention	NOUN
bam-1791	416	17	of	of	ADP
bam-1791	416	18	muscle	muscle	NOUN
bam-1791	416	19	wasting	waste	VERB
bam-1791	416	20	in	in	ADP
bam-1791	416	21	many	many	ADJ
bam-1791	416	22	systemic	systemic	ADJ
bam-1791	416	23	diseases	disease	NOUN
bam-1791	416	24	and	and	CCONJ
bam-1791	416	25	to	to	PART
bam-1791	416	26	promote	promote	VERB
bam-1791	416	27	recovery	recovery	NOUN
bam-1791	416	28	.	.	PUNCT
bam-1791	417	1	36	36	NUM
bam-1791	417	2	.	.	PUNCT
bam-1791	417	3	study	study	NOUN
bam-1791	417	4	of	of	ADP
bam-1791	417	5	the	the	DET
bam-1791	417	6	role	role	NOUN
bam-1791	417	7	of	of	ADP
bam-1791	417	8	mitochondrial	mitochondrial	ADJ
bam-1791	417	9	protein	protein	NOUN
bam-1791	417	10	opa1	opa1	VERB
bam-1791	417	11	in	in	ADP
bam-1791	417	12	skeletal	skeletal	ADJ
bam-1791	417	13	muscle	muscle	NOUN
bam-1791	417	14	caterina	caterina	PROPN
bam-1791	417	15	tezze(1	tezze(1	PROPN
bam-1791	417	16	)	)	PUNCT
bam-1791	417	17	,	,	PUNCT
bam-1791	417	18	vanina	vanina	ADJ
bam-1791	417	19	romanello(1	romanello(1	NOUN
bam-1791	417	20	)	)	PUNCT
bam-1791	417	21	,	,	PUNCT
bam-1791	417	22	maria	maria	PROPN
bam-1791	417	23	eugenia	eugenia	PROPN
bam-1791	417	24	soriano(1	soriano(1	PROPN
bam-1791	417	25	)	)	PUNCT
bam-1791	417	26	,	,	PUNCT
bam-1791	417	27	marian	marian	PROPN
bam-1791	417	28	desbats(2	desbats(2	PROPN
bam-1791	417	29	)	)	PUNCT
bam-1791	417	30	,	,	PUNCT
bam-1791	417	31	leonardo	leonardo	PROPN
bam-1791	417	32	salviati(2	salviati(2	PROPN
bam-1791	417	33	)	)	PUNCT
bam-1791	417	34	,	,	PUNCT
bam-1791	417	35	luca	luca	PROPN
bam-1791	417	36	scorrano(1	scorrano(1	NOUN
bam-1791	417	37	)	)	PUNCT
bam-1791	417	38	and	and	CCONJ
bam-1791	417	39	marco	marco	PROPN
bam-1791	417	40	sandri(1	sandri(1	PROPN
bam-1791	417	41	)	)	PUNCT
bam-1791	417	42	1dulbecco	1dulbecco	NUM
bam-1791	417	43	telethon	telethon	PROPN
bam-1791	417	44	institute	institute	NOUN
bam-1791	417	45	,	,	PUNCT
bam-1791	417	46	venetian	venetian	PROPN
bam-1791	417	47	institute	institute	NOUN
bam-1791	417	48	of	of	ADP
bam-1791	417	49	molecular	molecular	ADJ
bam-1791	417	50	medicine	medicine	NOUN
bam-1791	417	51	,	,	PUNCT
bam-1791	417	52	35129	35129	NUM
bam-1791	417	53	padova	padova	PROPN
bam-1791	417	54	,	,	PUNCT
bam-1791	417	55	italy	italy	PROPN
bam-1791	417	56	2clinical	2clinical	NUM
bam-1791	417	57	genetics	genetic	NOUN
bam-1791	417	58	unit	unit	NOUN
bam-1791	417	59	,	,	PUNCT
bam-1791	417	60	department	department	NOUN
bam-1791	417	61	of	of	ADP
bam-1791	417	62	pediatrics	pediatric	NOUN
bam-1791	417	63	,	,	PUNCT
bam-1791	417	64	university	university	NOUN
bam-1791	417	65	of	of	ADP
bam-1791	417	66	padova	padova	PROPN
bam-1791	417	67	,	,	PUNCT
bam-1791	417	68	padova	padova	PROPN
bam-1791	417	69	,	,	PUNCT
bam-1791	417	70	italy	italy	PROPN
bam-1791	417	71	mitochondria	mitochondria	PROPN
bam-1791	417	72	are	be	AUX
bam-1791	417	73	dynamic	dynamic	ADJ
bam-1791	417	74	organelles	organelle	NOUN
bam-1791	417	75	which	which	PRON
bam-1791	417	76	adapt	adapt	VERB
bam-1791	417	77	their	their	PRON
bam-1791	417	78	morphology	morphology	NOUN
bam-1791	417	79	by	by	ADP
bam-1791	417	80	fusion	fusion	NOUN
bam-1791	417	81	and	and	CCONJ
bam-1791	417	82	fission	fission	NOUN
bam-1791	417	83	events	event	NOUN
bam-1791	417	84	to	to	ADP
bam-1791	417	85	the	the	DET
bam-1791	417	86	bioenergetic	bioenergetic	ADJ
bam-1791	417	87	requirements	requirement	NOUN
bam-1791	417	88	of	of	ADP
bam-1791	417	89	the	the	DET
bam-1791	417	90	cell	cell	NOUN
bam-1791	417	91	.	.	PUNCT
bam-1791	418	1	skeletal	skeletal	ADJ
bam-1791	418	2	muscle	muscle	NOUN
bam-1791	418	3	is	be	AUX
bam-1791	418	4	a	a	DET
bam-1791	418	5	tissue	tissue	NOUN
bam-1791	418	6	with	with	ADP
bam-1791	418	7	high	high	ADJ
bam-1791	418	8	energy	energy	NOUN
bam-1791	418	9	demand	demand	NOUN
bam-1791	418	10	and	and	CCONJ
bam-1791	418	11	mitochondrial	mitochondrial	ADJ
bam-1791	418	12	plasticity	plasticity	NOUN
bam-1791	418	13	plays	play	VERB
bam-1791	418	14	a	a	DET
bam-1791	418	15	key	key	ADJ
bam-1791	418	16	role	role	NOUN
bam-1791	418	17	on	on	ADP
bam-1791	418	18	its	its	PRON
bam-1791	418	19	homeostasis	homeostasis	NOUN
bam-1791	418	20	.	.	PUNCT
bam-1791	419	1	indeed	indeed	ADV
bam-1791	419	2	,	,	PUNCT
bam-1791	419	3	alterations	alteration	NOUN
bam-1791	419	4	in	in	ADP
bam-1791	419	5	mitochondrial	mitochondrial	ADJ
bam-1791	419	6	morphology	morphology	NOUN
bam-1791	419	7	,	,	PUNCT
bam-1791	419	8	distribution	distribution	NOUN
bam-1791	419	9	and	and	CCONJ
bam-1791	419	10	function	function	NOUN
bam-1791	419	11	are	be	AUX
bam-1791	419	12	common	common	ADJ
bam-1791	419	13	features	feature	NOUN
bam-1791	419	14	in	in	ADP
bam-1791	419	15	atrophying	atrophy	VERB
bam-1791	419	16	muscles	muscle	NOUN
bam-1791	419	17	.	.	PUNCT
bam-1791	420	1	moreover	moreover	ADV
bam-1791	420	2	,	,	PUNCT
bam-1791	420	3	dysregulation	dysregulation	NOUN
bam-1791	420	4	of	of	ADP
bam-1791	420	5	mitochondrial	mitochondrial	ADJ
bam-1791	420	6	dynamics	dynamic	NOUN
bam-1791	420	7	affects	affect	VERB
bam-1791	420	8	the	the	DET
bam-1791	420	9	signalling	signal	VERB
bam-1791	420	10	pathways	pathway	NOUN
bam-1791	420	11	that	that	PRON
bam-1791	420	12	regulate	regulate	VERB
bam-1791	420	13	muscle	muscle	NOUN
bam-1791	420	14	mass	mass	PROPN
bam-1791	420	15	.	.	PUNCT
bam-1791	421	1	mitochondrial	mitochondrial	ADJ
bam-1791	421	2	fission	fission	NOUN
bam-1791	421	3	is	be	AUX
bam-1791	421	4	largely	largely	ADV
bam-1791	421	5	controlled	control	VERB
bam-1791	421	6	by	by	ADP
bam-1791	421	7	drp1	drp1	PROPN
bam-1791	421	8	,	,	PUNCT
bam-1791	421	9	whereas	whereas	SCONJ
bam-1791	421	10	mitochondrial	mitochondrial	ADJ
bam-1791	421	11	fusion	fusion	NOUN
bam-1791	421	12	mainly	mainly	ADV
bam-1791	421	13	depends	depend	VERB
bam-1791	421	14	on	on	ADP
bam-1791	421	15	the	the	DET
bam-1791	421	16	activity	activity	NOUN
bam-1791	421	17	of	of	ADP
bam-1791	421	18	the	the	DET
bam-1791	421	19	mitofusins	mitofusin	NOUN
bam-1791	421	20	(	(	PUNCT
bam-1791	421	21	mfn1	mfn1	NOUN
bam-1791	421	22	and	and	CCONJ
bam-1791	421	23	mfn2	mfn2	PROPN
bam-1791	421	24	)	)	PUNCT
bam-1791	421	25	and	and	CCONJ
bam-1791	421	26	opa1	opa1	PROPN
bam-1791	421	27	.	.	PUNCT
bam-1791	422	1	to	to	PART
bam-1791	422	2	investigate	investigate	VERB
bam-1791	422	3	the	the	DET
bam-1791	422	4	in	in	ADP
bam-1791	422	5	vivo	vivo	ADJ
bam-1791	422	6	role	role	NOUN
bam-1791	422	7	of	of	ADP
bam-1791	422	8	the	the	DET
bam-1791	422	9	mitochondrial	mitochondrial	ADJ
bam-1791	422	10	fusion	fusion	NOUN
bam-1791	422	11	protein	protein	NOUN
bam-1791	422	12	opa1	opa1	PROPN
bam-1791	422	13	,	,	PUNCT
bam-1791	422	14	we	we	PRON
bam-1791	422	15	have	have	AUX
bam-1791	422	16	generated	generate	VERB
bam-1791	422	17	a	a	DET
bam-1791	422	18	skeletal	skeletal	ADJ
bam-1791	422	19	muscle	muscle	NOUN
bam-1791	422	20	-	-	PUNCT
bam-1791	422	21	specific	specific	ADJ
bam-1791	422	22	opa1	opa1	NOUN
bam-1791	422	23	knock	knock	VERB
bam-1791	422	24	-	-	PUNCT
bam-1791	422	25	out	out	ADP
bam-1791	422	26	mice	mouse	NOUN
bam-1791	422	27	.	.	PUNCT
bam-1791	423	1	interestingly	interestingly	ADV
bam-1791	423	2	,	,	PUNCT
bam-1791	423	3	opa1	opa1	ADJ
bam-1791	423	4	ablation	ablation	NOUN
bam-1791	423	5	in	in	ADP
bam-1791	423	6	muscles	muscle	NOUN
bam-1791	423	7	is	be	AUX
bam-1791	423	8	lethal	lethal	ADJ
bam-1791	423	9	at	at	ADP
bam-1791	423	10	post	post	ADJ
bam-1791	423	11	-	-	ADJ
bam-1791	423	12	natal	natal	ADJ
bam-1791	423	13	day	day	NOUN
bam-1791	423	14	8	8	NUM
bam-1791	423	15	.	.	PUNCT
bam-1791	424	1	opa1	opa1	PROPN
bam-1791	424	2	deficient	deficient	ADJ
bam-1791	424	3	mice	mouse	NOUN
bam-1791	424	4	exhibit	exhibit	VERB
bam-1791	424	5	a	a	DET
bam-1791	424	6	progressive	progressive	ADJ
bam-1791	424	7	decrease	decrease	NOUN
bam-1791	424	8	in	in	ADP
bam-1791	424	9	body	body	NOUN
bam-1791	424	10	weight	weight	NOUN
bam-1791	424	11	compared	compare	VERB
bam-1791	424	12	with	with	ADP
bam-1791	424	13	wild	wild	ADJ
bam-1791	424	14	-	-	PUNCT
bam-1791	424	15	type	type	NOUN
bam-1791	424	16	animals	animal	NOUN
bam-1791	424	17	.	.	PUNCT
bam-1791	425	1	muscle	muscle	NOUN
bam-1791	425	2	biogenesis	biogenesis	NOUN
bam-1791	425	3	in	in	ADP
bam-1791	425	4	opa1	opa1	NOUN
bam-1791	425	5	knock	knock	VERB
bam-1791	425	6	-	-	PUNCT
bam-1791	425	7	out	out	ADP
bam-1791	425	8	mice	mouse	NOUN
bam-1791	425	9	is	be	AUX
bam-1791	425	10	not	not	PART
bam-1791	425	11	compromised	compromise	VERB
bam-1791	425	12	but	but	CCONJ
bam-1791	425	13	they	they	PRON
bam-1791	425	14	display	display	VERB
bam-1791	425	15	a	a	DET
bam-1791	425	16	profound	profound	ADJ
bam-1791	425	17	atrophy	atrophy	NOUN
bam-1791	425	18	.	.	PUNCT
bam-1791	426	1	at	at	ADP
bam-1791	426	2	ultra	ultra	ADJ
bam-1791	426	3	-	-	ADJ
bam-1791	426	4	structural	structural	ADJ
bam-1791	426	5	level	level	NOUN
bam-1791	426	6	opa1	opa1	NOUN
bam-1791	426	7	-	-	PUNCT
bam-1791	426	8	deleted	delete	VERB
bam-1791	426	9	muscles	muscle	NOUN
bam-1791	426	10	maintain	maintain	VERB
bam-1791	426	11	sarcomere	sarcomere	ADJ
bam-1791	426	12	organization	organization	NOUN
bam-1791	426	13	but	but	CCONJ
bam-1791	426	14	show	show	VERB
bam-1791	426	15	mitochondria	mitochondria	PROPN
bam-1791	426	16	alterations	alteration	NOUN
bam-1791	426	17	and	and	CCONJ
bam-1791	426	18	appearence	appearence	NOUN
bam-1791	426	19	of	of	ADP
bam-1791	426	20	lipid	lipid	ADJ
bam-1791	426	21	droplets	droplet	NOUN
bam-1791	426	22	.	.	PUNCT
bam-1791	427	1	these	these	DET
bam-1791	427	2	preliminary	preliminary	ADJ
bam-1791	427	3	results	result	NOUN
bam-1791	427	4	,	,	PUNCT
bam-1791	427	5	strongly	strongly	ADV
bam-1791	427	6	suggest	suggest	VERB
bam-1791	427	7	the	the	DET
bam-1791	427	8	important	important	ADJ
bam-1791	427	9	contribution	contribution	NOUN
bam-1791	427	10	of	of	ADP
bam-1791	427	11	opa1	opa1	PROPN
bam-1791	427	12	in	in	ADP
bam-1791	427	13	the	the	DET
bam-1791	427	14	control	control	NOUN
bam-1791	427	15	of	of	ADP
bam-1791	427	16	the	the	DET
bam-1791	427	17	homeostasis	homeostasis	NOUN
bam-1791	427	18	of	of	ADP
bam-1791	427	19	skeletal	skeletal	ADJ
bam-1791	427	20	muscle	muscle	NOUN
bam-1791	427	21	and	and	CCONJ
bam-1791	427	22	open	open	VERB
bam-1791	427	23	a	a	DET
bam-1791	427	24	new	new	ADJ
bam-1791	427	25	set	set	NOUN
bam-1791	427	26	of	of	ADP
bam-1791	427	27	candidate	candidate	NOUN
bam-1791	427	28	targets	target	NOUN
bam-1791	427	29	for	for	ADP
bam-1791	427	30	developing	develop	VERB
bam-1791	427	31	new	new	ADJ
bam-1791	427	32	drugs	drug	NOUN
bam-1791	427	33	against	against	ADP
bam-1791	427	34	muscle	muscle	NOUN
bam-1791	427	35	loss	loss	NOUN
bam-1791	427	36	.	.	PUNCT
bam-1791	428	1	ix	ix	PROPN
bam-1791	428	2	iim	iim	PROPN
bam-1791	428	3	meeting	meeting	NOUN
bam-1791	428	4	,	,	PUNCT
bam-1791	428	5	acaya	acaya	NOUN
bam-1791	428	6	(	(	PUNCT
bam-1791	428	7	lecce	lecce	PROPN
bam-1791	428	8	)	)	PUNCT
bam-1791	428	9	,	,	PUNCT
bam-1791	428	10	october	october	PROPN
bam-1791	428	11	12	12	NUM
bam-1791	428	12	-	-	SYM
bam-1791	428	13	14	14	NUM
bam-1791	428	14	,	,	PUNCT
bam-1791	428	15	2012	2012	NUM
bam-1791	428	16	european	european	PROPN
bam-1791	428	17	journal	journal	PROPN
bam-1791	428	18	translational	translational	ADJ
bam-1791	428	19	myology	myology	NOUN
bam-1791	428	20	basic	basic	ADJ
bam-1791	428	21	applied	apply	VERB
bam-1791	428	22	myology	myology	NOUN
bam-1791	428	23	2012	2012	NUM
bam-1791	428	24	;	;	PUNCT
bam-1791	428	25	22(1&2	22(1&2	NUM
bam-1791	428	26	):	):	PUNCT
bam-1791	428	27	xxx	xxx	NOUN
bam-1791	428	28	-	-	PUNCT
bam-1791	428	29	xxx	xxx	PROPN
bam-1791	428	30	36	36	NUM
bam-1791	428	31	37	37	NUM
bam-1791	428	32	.	.	PUNCT
bam-1791	429	1	gene	gene	NOUN
bam-1791	429	2	expression	expression	NOUN
bam-1791	429	3	modulation	modulation	NOUN
bam-1791	429	4	of	of	ADP
bam-1791	429	5	thioredoxin	thioredoxin	PROPN
bam-1791	429	6	reductases	reductase	VERB
bam-1791	429	7	during	during	ADP
bam-1791	429	8	skeletal	skeletal	ADJ
bam-1791	429	9	muscle	muscle	NOUN
bam-1791	429	10	ageing	age	VERB
bam-1791	429	11	ivan	ivan	PROPN
bam-1791	429	12	dimauro1	dimauro1	PROPN
bam-1791	429	13	,	,	PUNCT
bam-1791	429	14	maria	maria	PROPN
bam-1791	429	15	paola	paola	PROPN
bam-1791	429	16	paronetto1,2	paronetto1,2	PROPN
bam-1791	429	17	,	,	PUNCT
bam-1791	429	18	timothy	timothy	PROPN
bam-1791	429	19	pearson3	pearson3	PROPN
bam-1791	429	20	,	,	PUNCT
bam-1791	429	21	malcolm	malcolm	PROPN
bam-1791	429	22	j	j	PROPN
bam-1791	429	23	jackson3	jackson3	PROPN
bam-1791	429	24	,	,	PUNCT
bam-1791	429	25	paolo	paolo	PROPN
bam-1791	429	26	parisi1	parisi1	PROPN
bam-1791	429	27	,	,	PUNCT
bam-1791	430	1	daniela	daniela	PROPN
bam-1791	430	2	caporossi1	caporossi1	PROPN
bam-1791	431	1	1department	1department	NUM
bam-1791	431	2	of	of	ADP
bam-1791	431	3	health	health	NOUN
bam-1791	431	4	sciences	sciences	PROPN
bam-1791	431	5	,	,	PUNCT
bam-1791	431	6	university	university	NOUN
bam-1791	431	7	of	of	ADP
bam-1791	431	8	rome	rome	PROPN
bam-1791	431	9	“	"	PUNCT
bam-1791	431	10	foro	foro	PROPN
bam-1791	431	11	italico	italico	PROPN
bam-1791	431	12	”	"	PUNCT
bam-1791	431	13	,	,	PUNCT
bam-1791	431	14	piazza	piazza	VERB
bam-1791	431	15	lauro	lauro	PROPN
bam-1791	431	16	de	de	ADP
bam-1791	431	17	bosis	bosis	PROPN
bam-1791	431	18	15	15	NUM
bam-1791	431	19	,	,	PUNCT
bam-1791	431	20	00194	00194	NUM
bam-1791	432	1	rome	rome	PROPN
bam-1791	432	2	,	,	PUNCT
bam-1791	432	3	italy	italy	PROPN
bam-1791	432	4	.	.	PROPN
bam-1791	433	1	2	2	NUM
bam-1791	433	2	cerc	cerc	NOUN
bam-1791	433	3	fondazione	fondazione	NOUN
bam-1791	433	4	santa	santa	PROPN
bam-1791	433	5	lucia	lucia	PROPN
bam-1791	433	6	,	,	PUNCT
bam-1791	433	7	via	via	ADP
bam-1791	433	8	del	del	PROPN
bam-1791	433	9	fosso	fosso	PROPN
bam-1791	433	10	di	di	PROPN
bam-1791	433	11	fiorano	fiorano	PROPN
bam-1791	433	12	64	64	NUM
bam-1791	433	13	,	,	PUNCT
bam-1791	433	14	00143	00143	NUM
bam-1791	433	15	,	,	PUNCT
bam-1791	433	16	rome	rome	PROPN
bam-1791	433	17	,	,	PUNCT
bam-1791	433	18	italy	italy	PROPN
bam-1791	433	19	2institute	2institute	NUM
bam-1791	433	20	of	of	ADP
bam-1791	433	21	ageing	age	VERB
bam-1791	433	22	and	and	CCONJ
bam-1791	433	23	chronic	chronic	ADJ
bam-1791	433	24	disease	disease	NOUN
bam-1791	433	25	,	,	PUNCT
bam-1791	433	26	university	university	NOUN
bam-1791	433	27	of	of	ADP
bam-1791	433	28	liverpool	liverpool	PROPN
bam-1791	433	29	,	,	PUNCT
bam-1791	433	30	daulby	daulby	PROPN
bam-1791	433	31	street	street	PROPN
bam-1791	433	32	,	,	PUNCT
bam-1791	433	33	liverpool	liverpool	PROPN
bam-1791	433	34	,	,	PUNCT
bam-1791	433	35	l69	l69	NOUN
bam-1791	433	36	3ga	3ga	NOUN
bam-1791	433	37	,	,	PUNCT
bam-1791	433	38	united	united	ADJ
bam-1791	433	39	kingdom	kingdom	PROPN
bam-1791	433	40	.	.	PUNCT
bam-1791	434	1	trx	trx	NOUN
bam-1791	434	2	system	system	NOUN
bam-1791	434	3	is	be	AUX
bam-1791	434	4	one	one	NUM
bam-1791	434	5	of	of	ADP
bam-1791	434	6	the	the	DET
bam-1791	434	7	most	most	ADV
bam-1791	434	8	important	important	ADJ
bam-1791	434	9	redox	redox	NOUN
bam-1791	434	10	-	-	PUNCT
bam-1791	434	11	regulating	regulate	VERB
bam-1791	434	12	antioxidant	antioxidant	NOUN
bam-1791	434	13	complex	complex	NOUN
bam-1791	434	14	with	with	ADP
bam-1791	434	15	significant	significant	ADJ
bam-1791	434	16	quenching	quenching	NOUN
bam-1791	434	17	capability	capability	NOUN
bam-1791	434	18	against	against	ADP
bam-1791	434	19	induced	induce	VERB
bam-1791	434	20	oxidative	oxidative	ADJ
bam-1791	434	21	stress	stress	NOUN
bam-1791	434	22	.	.	PUNCT
bam-1791	435	1	this	this	DET
bam-1791	435	2	antioxidant	antioxidant	ADJ
bam-1791	435	3	system	system	NOUN
bam-1791	435	4	contains	contain	VERB
bam-1791	435	5	two	two	NUM
bam-1791	435	6	major	major	ADJ
bam-1791	435	7	forms	form	NOUN
bam-1791	435	8	of	of	ADP
bam-1791	435	9	thioredoxin	thioredoxin	PROPN
bam-1791	435	10	,	,	PUNCT
bam-1791	435	11	trx1	trx1	PROPN
bam-1791	435	12	,	,	PUNCT
bam-1791	435	13	mainly	mainly	ADV
bam-1791	435	14	cytosolic	cytosolic	ADJ
bam-1791	435	15	(	(	PUNCT
bam-1791	435	16	the	the	DET
bam-1791	435	17	txn	txn	PROPN
bam-1791	435	18	gene	gene	NOUN
bam-1791	435	19	product	product	NOUN
bam-1791	435	20	)	)	PUNCT
bam-1791	435	21	and	and	CCONJ
bam-1791	435	22	mitochondrial	mitochondrial	ADJ
bam-1791	435	23	trx2	trx2	NOUN
bam-1791	435	24	(	(	PUNCT
bam-1791	435	25	the	the	DET
bam-1791	435	26	txn2	txn2	NOUN
bam-1791	435	27	gene	gene	NOUN
bam-1791	435	28	product	product	NOUN
bam-1791	435	29	)	)	PUNCT
bam-1791	435	30	as	as	ADV
bam-1791	435	31	well	well	ADV
bam-1791	435	32	as	as	ADP
bam-1791	435	33	a	a	DET
bam-1791	435	34	nadph	nadph	ADJ
bam-1791	435	35	-	-	PUNCT
bam-1791	435	36	dependent	dependent	ADJ
bam-1791	435	37	thioredoxin	thioredoxin	PROPN
bam-1791	435	38	reductase	reductase	NOUN
bam-1791	435	39	(	(	PUNCT
bam-1791	435	40	trxr	trxr	NOUN
bam-1791	435	41	)	)	PUNCT
bam-1791	435	42	,	,	PUNCT
bam-1791	435	43	which	which	PRON
bam-1791	435	44	reduces	reduce	VERB
bam-1791	435	45	the	the	DET
bam-1791	435	46	oxidized	oxidized	ADJ
bam-1791	435	47	form	form	NOUN
bam-1791	435	48	of	of	ADP
bam-1791	435	49	thioredoxin	thioredoxin	PROPN
bam-1791	435	50	and	and	CCONJ
bam-1791	435	51	other	other	ADJ
bam-1791	435	52	protein	protein	NOUN
bam-1791	435	53	or	or	CCONJ
bam-1791	435	54	non	non	ADJ
bam-1791	435	55	-	-	ADJ
bam-1791	435	56	protein	protein	ADJ
bam-1791	435	57	substrates	substrate	NOUN
bam-1791	435	58	.	.	PUNCT
bam-1791	436	1	thioredoxin	thioredoxin	PROPN
bam-1791	436	2	reductases	reductase	NOUN
bam-1791	436	3	are	be	AUX
bam-1791	436	4	encoded	encode	VERB
bam-1791	436	5	by	by	ADP
bam-1791	436	6	three	three	NUM
bam-1791	436	7	separate	separate	ADJ
bam-1791	436	8	genes	gene	NOUN
bam-1791	436	9	:	:	PUNCT
bam-1791	436	10	txnrd1	txnrd1	NOUN
bam-1791	436	11	encodes	encode	VERB
bam-1791	436	12	the	the	DET
bam-1791	436	13	cytosolic	cytosolic	ADJ
bam-1791	436	14	trxr1	trxr1	NOUN
bam-1791	436	15	;	;	PUNCT
bam-1791	436	16	txnrd2	txnrd2	NOUN
bam-1791	436	17	encodes	encode	VERB
bam-1791	436	18	the	the	DET
bam-1791	436	19	mitochondrial	mitochondrial	ADJ
bam-1791	436	20	trxr2	trxr2	NOUN
bam-1791	436	21	and	and	CCONJ
bam-1791	436	22	txnrd3	txnrd3	NOUN
bam-1791	436	23	encodes	encode	NOUN
bam-1791	436	24	trxr3	trxr3	NOUN
bam-1791	436	25	,	,	PUNCT
bam-1791	436	26	predominantly	predominantly	ADV
bam-1791	436	27	expressed	express	VERB
bam-1791	436	28	in	in	ADP
bam-1791	436	29	testis	testis	NOUN
bam-1791	436	30	.	.	PUNCT
bam-1791	437	1	each	each	PRON
bam-1791	437	2	of	of	ADP
bam-1791	437	3	them	they	PRON
bam-1791	437	4	gives	give	VERB
bam-1791	437	5	rise	rise	NOUN
bam-1791	437	6	to	to	ADP
bam-1791	437	7	several	several	ADJ
bam-1791	437	8	different	different	ADJ
bam-1791	437	9	splice	splice	NOUN
bam-1791	437	10	variants	variant	NOUN
bam-1791	437	11	.	.	PUNCT
bam-1791	438	1	despite	despite	SCONJ
bam-1791	438	2	increasing	increase	VERB
bam-1791	438	3	evidence	evidence	NOUN
bam-1791	438	4	suggests	suggest	VERB
bam-1791	438	5	the	the	DET
bam-1791	438	6	involvement	involvement	NOUN
bam-1791	438	7	of	of	ADP
bam-1791	438	8	the	the	DET
bam-1791	438	9	trx	trx	NOUN
bam-1791	438	10	system	system	NOUN
bam-1791	438	11	in	in	ADP
bam-1791	438	12	several	several	ADJ
bam-1791	438	13	human	human	ADJ
bam-1791	438	14	diseases	disease	NOUN
bam-1791	438	15	and	and	CCONJ
bam-1791	438	16	pathological	pathological	ADJ
bam-1791	438	17	conditions	condition	NOUN
bam-1791	438	18	,	,	PUNCT
bam-1791	438	19	very	very	ADV
bam-1791	438	20	little	little	ADJ
bam-1791	438	21	is	be	AUX
bam-1791	438	22	known	know	VERB
bam-1791	438	23	about	about	ADP
bam-1791	438	24	its	its	PRON
bam-1791	438	25	role	role	NOUN
bam-1791	438	26	in	in	ADP
bam-1791	438	27	the	the	DET
bam-1791	438	28	regulation	regulation	NOUN
bam-1791	438	29	of	of	ADP
bam-1791	438	30	skeletal	skeletal	ADJ
bam-1791	438	31	muscle	muscle	NOUN
bam-1791	438	32	adaptation	adaptation	NOUN
bam-1791	438	33	and	and	CCONJ
bam-1791	438	34	contractile	contractile	NOUN
bam-1791	438	35	activity	activity	NOUN
bam-1791	438	36	during	during	ADP
bam-1791	438	37	ageing	ageing	NOUN
bam-1791	438	38	.	.	PUNCT
bam-1791	439	1	recently	recently	ADV
bam-1791	439	2	,	,	PUNCT
bam-1791	439	3	we	we	PRON
bam-1791	439	4	showed	show	VERB
bam-1791	439	5	that	that	SCONJ
bam-1791	439	6	glutathione	glutathione	NOUN
bam-1791	439	7	redox	redox	ADJ
bam-1791	439	8	couples	couple	NOUN
bam-1791	439	9	in	in	ADP
bam-1791	439	10	skeletal	skeletal	ADJ
bam-1791	439	11	muscle	muscle	NOUN
bam-1791	439	12	are	be	AUX
bam-1791	439	13	more	more	ADV
bam-1791	439	14	susceptible	susceptible	ADJ
bam-1791	439	15	to	to	ADP
bam-1791	439	16	oxidation	oxidation	NOUN
bam-1791	439	17	than	than	ADP
bam-1791	439	18	trxs	trxs	NOUN
bam-1791	439	19	and	and	CCONJ
bam-1791	439	20	that	that	SCONJ
bam-1791	439	21	,	,	PUNCT
bam-1791	439	22	although	although	SCONJ
bam-1791	439	23	trx	trx	NOUN
bam-1791	439	24	proteins	protein	NOUN
bam-1791	439	25	were	be	AUX
bam-1791	439	26	up	up	ADV
bam-1791	439	27	-	-	PUNCT
bam-1791	439	28	regulated	regulate	VERB
bam-1791	439	29	in	in	ADP
bam-1791	439	30	skeletal	skeletal	ADJ
bam-1791	439	31	muscle	muscle	NOUN
bam-1791	439	32	of	of	ADP
bam-1791	439	33	aged	aged	ADJ
bam-1791	439	34	mice	mouse	NOUN
bam-1791	439	35	,	,	PUNCT
bam-1791	439	36	they	they	PRON
bam-1791	439	37	do	do	AUX
bam-1791	439	38	not	not	PART
bam-1791	439	39	modulate	modulate	VERB
bam-1791	439	40	the	the	DET
bam-1791	439	41	redox	redox	NOUN
bam-1791	439	42	-	-	PUNCT
bam-1791	439	43	regulated	regulate	VERB
bam-1791	439	44	adaptation	adaptation	NOUN
bam-1791	439	45	to	to	ADP
bam-1791	439	46	contractile	contractile	ADJ
bam-1791	439	47	activity	activity	NOUN
bam-1791	439	48	that	that	PRON
bam-1791	439	49	fails	fail	VERB
bam-1791	439	50	during	during	ADP
bam-1791	439	51	ageing	age	VERB
bam-1791	439	52	(	(	PUNCT
bam-1791	439	53	dimauro	dimauro	NOUN
bam-1791	439	54	et	et	PROPN
bam-1791	439	55	al	al	PROPN
bam-1791	439	56	.	.	PROPN
bam-1791	439	57	,	,	PUNCT
bam-1791	439	58	2012	2012	NUM
bam-1791	439	59	)	)	PUNCT
bam-1791	439	60	.	.	PUNCT
bam-1791	440	1	starting	start	VERB
bam-1791	440	2	from	from	ADP
bam-1791	440	3	these	these	DET
bam-1791	440	4	results	result	NOUN
bam-1791	440	5	,	,	PUNCT
bam-1791	440	6	we	we	PRON
bam-1791	440	7	hypothesize	hypothesize	VERB
bam-1791	440	8	that	that	SCONJ
bam-1791	440	9	exogenous	exogenous	ADJ
bam-1791	440	10	ros	ro	NOUN
bam-1791	440	11	and	and	CCONJ
bam-1791	440	12	the	the	DET
bam-1791	440	13	ageing	age	VERB
bam-1791	440	14	process	process	NOUN
bam-1791	440	15	would	would	AUX
bam-1791	440	16	differently	differently	ADV
bam-1791	440	17	modulate	modulate	VERB
bam-1791	440	18	the	the	DET
bam-1791	440	19	trxr	trxr	NOUN
bam-1791	440	20	transcripts	transcript	NOUN
bam-1791	440	21	and	and	CCONJ
bam-1791	440	22	isoforms	isoform	NOUN
bam-1791	440	23	,	,	PUNCT
bam-1791	440	24	thus	thus	ADV
bam-1791	440	25	regulating	regulate	VERB
bam-1791	440	26	the	the	DET
bam-1791	440	27	adaptive	adaptive	ADJ
bam-1791	440	28	process	process	NOUN
bam-1791	440	29	in	in	ADP
bam-1791	440	30	these	these	DET
bam-1791	440	31	systems	system	NOUN
bam-1791	440	32	.	.	PUNCT
bam-1791	441	1	in	in	ADP
bam-1791	441	2	order	order	NOUN
bam-1791	441	3	to	to	PART
bam-1791	441	4	verify	verify	VERB
bam-1791	441	5	this	this	DET
bam-1791	441	6	hypothesis	hypothesis	NOUN
bam-1791	441	7	,	,	PUNCT
bam-1791	441	8	we	we	PRON
bam-1791	441	9	investigated	investigate	VERB
bam-1791	441	10	the	the	DET
bam-1791	441	11	expression	expression	NOUN
bam-1791	441	12	profile	profile	NOUN
bam-1791	441	13	of	of	ADP
bam-1791	441	14	trxr	trxr	NOUN
bam-1791	441	15	in	in	ADP
bam-1791	441	16	skeletal	skeletal	ADJ
bam-1791	441	17	muscle	muscle	NOUN
bam-1791	441	18	tissue	tissue	NOUN
bam-1791	441	19	and	and	CCONJ
bam-1791	441	20	cells	cell	NOUN
bam-1791	441	21	.	.	PUNCT
bam-1791	442	1	our	our	PRON
bam-1791	442	2	preliminary	preliminary	ADJ
bam-1791	442	3	data	datum	NOUN
bam-1791	442	4	document	document	NOUN
bam-1791	442	5	the	the	DET
bam-1791	442	6	differential	differential	ADJ
bam-1791	442	7	expression	expression	NOUN
bam-1791	442	8	of	of	ADP
bam-1791	442	9	trxr	trxr	NOUN
bam-1791	442	10	isoforms	isoform	VERB
bam-1791	442	11	both	both	CCONJ
bam-1791	442	12	at	at	ADP
bam-1791	442	13	mrna	mrna	NOUN
bam-1791	442	14	and	and	CCONJ
bam-1791	442	15	protein	protein	NOUN
bam-1791	442	16	level	level	NOUN
bam-1791	442	17	in	in	ADP
bam-1791	442	18	c2c12	c2c12	PROPN
bam-1791	442	19	myotubes	myotube	NOUN
bam-1791	442	20	.	.	PUNCT
bam-1791	443	1	the	the	DET
bam-1791	443	2	exposure	exposure	NOUN
bam-1791	443	3	of	of	ADP
bam-1791	443	4	these	these	DET
bam-1791	443	5	cells	cell	NOUN
bam-1791	443	6	to	to	PART
bam-1791	443	7	h2o2	h2o2	VERB
bam-1791	443	8	determined	determine	VERB
bam-1791	443	9	an	an	DET
bam-1791	443	10	increase	increase	NOUN
bam-1791	443	11	of	of	ADP
bam-1791	443	12	the	the	DET
bam-1791	443	13	four	four	NUM
bam-1791	443	14	mrna	mrna	PROPN
bam-1791	443	15	trxr1	trxr1	NOUN
bam-1791	443	16	isoforms	isoform	NOUN
bam-1791	443	17	analyzed	analyze	VERB
bam-1791	443	18	,	,	PUNCT
bam-1791	443	19	while	while	SCONJ
bam-1791	443	20	trxr2	trxr2	NOUN
bam-1791	443	21	isoforms	isoform	NOUN
bam-1791	443	22	were	be	AUX
bam-1791	443	23	unaffected	unaffected	ADJ
bam-1791	443	24	.	.	PUNCT
bam-1791	444	1	although	although	SCONJ
bam-1791	444	2	further	further	ADJ
bam-1791	444	3	studies	study	NOUN
bam-1791	444	4	are	be	AUX
bam-1791	444	5	needed	need	VERB
bam-1791	444	6	to	to	PART
bam-1791	444	7	define	define	VERB
bam-1791	444	8	the	the	DET
bam-1791	444	9	role	role	NOUN
bam-1791	444	10	played	play	VERB
bam-1791	444	11	by	by	ADP
bam-1791	444	12	trxr	trxr	NOUN
bam-1791	444	13	coand	coand	NOUN
bam-1791	444	14	post	post	ADJ
bam-1791	444	15	-	-	ADJ
bam-1791	444	16	transcriptional	transcriptional	ADJ
bam-1791	444	17	regulation	regulation	NOUN
bam-1791	444	18	upon	upon	SCONJ
bam-1791	444	19	oxidative	oxidative	ADJ
bam-1791	444	20	stress	stress	NOUN
bam-1791	444	21	and	and	CCONJ
bam-1791	444	22	their	their	PRON
bam-1791	444	23	biological	biological	ADJ
bam-1791	444	24	significance	significance	NOUN
bam-1791	444	25	,	,	PUNCT
bam-1791	444	26	a	a	DET
bam-1791	444	27	detailed	detailed	ADJ
bam-1791	444	28	elucidation	elucidation	NOUN
bam-1791	444	29	of	of	ADP
bam-1791	444	30	these	these	DET
bam-1791	444	31	mechanisms	mechanism	NOUN
bam-1791	444	32	in	in	ADP
bam-1791	444	33	both	both	CCONJ
bam-1791	444	34	normal	normal	ADJ
bam-1791	444	35	and	and	CCONJ
bam-1791	444	36	ageing	age	VERB
bam-1791	444	37	process	process	NOUN
bam-1791	444	38	may	may	AUX
bam-1791	444	39	provide	provide	VERB
bam-1791	444	40	new	new	ADJ
bam-1791	444	41	insights	insight	NOUN
bam-1791	444	42	into	into	ADP
bam-1791	444	43	ageing	age	VERB
bam-1791	444	44	mechanisms	mechanism	NOUN
bam-1791	444	45	and	and	CCONJ
bam-1791	444	46	contribute	contribute	VERB
bam-1791	444	47	to	to	ADP
bam-1791	444	48	the	the	DET
bam-1791	444	49	development	development	NOUN
bam-1791	444	50	of	of	ADP
bam-1791	444	51	novel	novel	ADJ
bam-1791	444	52	treatments	treatment	NOUN
bam-1791	444	53	for	for	ADP
bam-1791	444	54	human	human	ADJ
bam-1791	444	55	diseases	disease	NOUN
bam-1791	444	56	.	.	PUNCT
bam-1791	445	1	38	38	NUM
bam-1791	445	2	.	.	PUNCT
bam-1791	446	1	plin2	plin2	NOUN
bam-1791	446	2	expression	expression	NOUN
bam-1791	446	3	in	in	ADP
bam-1791	446	4	human	human	ADJ
bam-1791	446	5	skeletal	skeletal	ADJ
bam-1791	446	6	muscle	muscle	NOUN
bam-1791	446	7	is	be	AUX
bam-1791	446	8	associated	associate	VERB
bam-1791	446	9	with	with	ADP
bam-1791	446	10	inactivity	inactivity	NOUN
bam-1791	446	11	and	and	CCONJ
bam-1791	446	12	aging	age	VERB
bam-1791	446	13	maria	maria	PROPN
bam-1791	446	14	conte1	conte1	PROPN
bam-1791	446	15	,	,	PUNCT
bam-1791	446	16	francesco	francesco	PROPN
bam-1791	446	17	vasuri2	vasuri2	PROPN
bam-1791	446	18	,	,	PUNCT
bam-1791	446	19	giovanni	giovanni	PROPN
bam-1791	446	20	trisolino3	trisolino3	PROPN
bam-1791	446	21	,	,	PUNCT
bam-1791	446	22	elena	elena	PROPN
bam-1791	446	23	bellavista1	bellavista1	PROPN
bam-1791	446	24	,	,	PUNCT
bam-1791	446	25	aurelia	aurelia	PROPN
bam-1791	446	26	santoro1	santoro1	NOUN
bam-1791	446	27	,	,	PUNCT
bam-1791	446	28	alessio	alessio	PROPN
bam-1791	446	29	degiovanni2	degiovanni2	PROPN
bam-1791	446	30	,	,	PUNCT
bam-1791	446	31	ermanno	ermanno	PROPN
bam-1791	446	32	martucci3	martucci3	PROPN
bam-1791	446	33	,	,	PUNCT
bam-1791	446	34	antonia	antonia	PROPN
bam-1791	446	35	d’errico	d’errico	PROPN
bam-1791	446	36	-	-	PUNCT
bam-1791	446	37	grigioni2	grigioni2	PROPN
bam-1791	446	38	,	,	PUNCT
bam-1791	446	39	daniela	daniela	PROPN
bam-1791	446	40	caporossi4	caporossi4	PROPN
bam-1791	446	41	,	,	PUNCT
bam-1791	446	42	miriam	miriam	PROPN
bam-1791	446	43	capri1	capri1	PROPN
bam-1791	446	44	,	,	PUNCT
bam-1791	446	45	andrea	andrea	PROPN
bam-1791	446	46	b.	b.	PROPN
bam-1791	446	47	maier5	maier5	PROPN
bam-1791	446	48	,	,	PUNCT
bam-1791	446	49	olivier	olivier	PROPN
bam-1791	446	50	seynnes6	seynnes6	PROPN
bam-1791	446	51	,	,	PUNCT
bam-1791	446	52	marco	marco	PROPN
bam-1791	446	53	narici7	narici7	PROPN
bam-1791	446	54	,	,	PUNCT
bam-1791	446	55	claudio	claudio	NOUN
bam-1791	446	56	franceschi1	franceschi1	PROPN
bam-1791	446	57	,	,	PUNCT
bam-1791	446	58	stefano	stefano	PROPN
bam-1791	446	59	salvioli1	salvioli1	PROPN
bam-1791	446	60	1department	1department	NUM
bam-1791	446	61	of	of	ADP
bam-1791	446	62	experimental	experimental	ADJ
bam-1791	446	63	pathology	pathology	NOUN
bam-1791	446	64	and	and	CCONJ
bam-1791	446	65	interdepartmental	interdepartmental	ADJ
bam-1791	446	66	centre	centre	NOUN
bam-1791	446	67	“	"	PUNCT
bam-1791	446	68	l.	l.	PROPN
bam-1791	446	69	galvani	galvani	PROPN
bam-1791	446	70	”	"	PUNCT
bam-1791	446	71	(	(	PUNCT
bam-1791	446	72	cig	cig	PROPN
bam-1791	446	73	)	)	PUNCT
bam-1791	446	74	,	,	PUNCT
bam-1791	446	75	university	university	NOUN
bam-1791	446	76	of	of	ADP
bam-1791	446	77	bologna	bologna	PROPN
bam-1791	446	78	,	,	PUNCT
bam-1791	446	79	italy	italy	PROPN
bam-1791	446	80	.	.	PUNCT
bam-1791	447	1	2“f	2“f	PROPN
bam-1791	447	2	.	.	PROPN
bam-1791	447	3	addarii	addarii	PROPN
bam-1791	447	4	”	"	PUNCT
bam-1791	447	5	institute	institute	PROPN
bam-1791	447	6	of	of	ADP
bam-1791	447	7	oncology	oncology	NOUN
bam-1791	447	8	and	and	CCONJ
bam-1791	447	9	transplant	transplant	NOUN
bam-1791	447	10	pathology	pathology	NOUN
bam-1791	447	11	,	,	PUNCT
bam-1791	447	12	s.orsola	s.orsola	X
bam-1791	447	13	-	-	PUNCT
bam-1791	447	14	malpighi	malpighi	PROPN
bam-1791	447	15	hospital	hospital	NOUN
bam-1791	447	16	,	,	PUNCT
bam-1791	447	17	university	university	NOUN
bam-1791	447	18	of	of	ADP
bam-1791	447	19	bologna	bologna	PROPN
bam-1791	447	20	,	,	PUNCT
bam-1791	447	21	italy	italy	PROPN
bam-1791	447	22	.	.	PUNCT
bam-1791	448	1	3reconstructive	3reconstructive	NUM
bam-1791	448	2	hip	hip	NOUN
bam-1791	448	3	and	and	CCONJ
bam-1791	448	4	knee	knee	NOUN
bam-1791	448	5	joint	joint	ADJ
bam-1791	448	6	surgery	surgery	NOUN
bam-1791	448	7	,	,	PUNCT
bam-1791	448	8	istituto	istituto	PROPN
bam-1791	448	9	ortopedico	ortopedico	PROPN
bam-1791	448	10	rizzoli	rizzoli	NOUN
bam-1791	448	11	,	,	PUNCT
bam-1791	448	12	bologna	bologna	PROPN
bam-1791	448	13	italy	italy	PROPN
bam-1791	448	14	.	.	PUNCT
bam-1791	449	1	4	4	NUM
bam-1791	449	2	department	department	PROPN
bam-1791	449	3	of	of	ADP
bam-1791	449	4	health	health	NOUN
bam-1791	449	5	science	science	NOUN
bam-1791	449	6	,	,	PUNCT
bam-1791	449	7	university	university	PROPN
bam-1791	449	8	of	of	ADP
bam-1791	449	9	rome	rome	PROPN
bam-1791	449	10	“	"	PUNCT
bam-1791	449	11	foro	foro	PROPN
bam-1791	449	12	italico	italico	PROPN
bam-1791	449	13	”	"	PUNCT
bam-1791	449	14	,	,	PUNCT
bam-1791	449	15	rome	rome	PROPN
bam-1791	449	16	,	,	PUNCT
bam-1791	449	17	italy	italy	PROPN
bam-1791	449	18	5department	5department	NUM
bam-1791	449	19	of	of	ADP
bam-1791	449	20	gerontology	gerontology	NOUN
bam-1791	449	21	and	and	CCONJ
bam-1791	449	22	geriatrics	geriatric	NOUN
bam-1791	449	23	,	,	PUNCT
bam-1791	449	24	leiden	leiden	PROPN
bam-1791	449	25	university	university	PROPN
bam-1791	449	26	medical	medical	ADJ
bam-1791	449	27	center	center	NOUN
bam-1791	449	28	,	,	PUNCT
bam-1791	449	29	leiden	leiden	PROPN
bam-1791	449	30	,	,	PUNCT
bam-1791	449	31	the	the	DET
bam-1791	449	32	netherlands	netherlands	PROPN
bam-1791	449	33	6	6	NUM
bam-1791	449	34	norwegian	norwegian	ADJ
bam-1791	449	35	school	school	NOUN
bam-1791	449	36	of	of	ADP
bam-1791	449	37	sport	sport	PROPN
bam-1791	449	38	sciences	sciences	PROPN
bam-1791	449	39	postboks	postboks	PROPN
bam-1791	449	40	4014	4014	NUM
bam-1791	449	41	ullevål	ullevål	PROPN
bam-1791	449	42	stadion	stadion	NOUN
bam-1791	449	43	,	,	PUNCT
bam-1791	449	44	oslo	oslo	PROPN
bam-1791	449	45	,	,	PUNCT
bam-1791	449	46	norway	norway	PROPN
bam-1791	449	47	7school	7school	NUM
bam-1791	449	48	of	of	ADP
bam-1791	449	49	graduate	graduate	NOUN
bam-1791	449	50	entry	entry	NOUN
bam-1791	449	51	medicine	medicine	NOUN
bam-1791	449	52	and	and	CCONJ
bam-1791	449	53	health	health	NOUN
bam-1791	449	54	,	,	PUNCT
bam-1791	449	55	division	division	NOUN
bam-1791	449	56	of	of	ADP
bam-1791	449	57	clinical	clinical	ADJ
bam-1791	449	58	physiology	physiology	NOUN
bam-1791	449	59	,	,	PUNCT
bam-1791	449	60	derby	derby	PROPN
bam-1791	449	61	royal	royal	ADJ
bam-1791	449	62	hospital	hospital	NOUN
bam-1791	449	63	,	,	PUNCT
bam-1791	449	64	university	university	PROPN
bam-1791	449	65	of	of	ADP
bam-1791	449	66	nottingham	nottingham	PROPN
bam-1791	449	67	,	,	PUNCT
bam-1791	449	68	uk	uk	PROPN
bam-1791	449	69	.	.	PUNCT
bam-1791	449	70	inter	inter	ADJ
bam-1791	449	71	-	-	ADJ
bam-1791	449	72	fibre	fibre	ADJ
bam-1791	449	73	muscle	muscle	NOUN
bam-1791	449	74	fat	fat	ADJ
bam-1791	449	75	infiltration	infiltration	NOUN
bam-1791	449	76	is	be	AUX
bam-1791	449	77	a	a	DET
bam-1791	449	78	phenomenon	phenomenon	NOUN
bam-1791	449	79	associated	associate	VERB
bam-1791	449	80	with	with	ADP
bam-1791	449	81	sarcopenia	sarcopenia	NOUN
bam-1791	449	82	and/or	and/or	CCONJ
bam-1791	449	83	physical	physical	ADJ
bam-1791	449	84	inactivity	inactivity	NOUN
bam-1791	449	85	.	.	PUNCT
bam-1791	450	1	much	much	ADV
bam-1791	450	2	less	less	ADJ
bam-1791	450	3	is	be	AUX
bam-1791	450	4	known	know	VERB
bam-1791	450	5	about	about	ADP
bam-1791	450	6	lipid	lipid	ADJ
bam-1791	450	7	deposition	deposition	NOUN
bam-1791	450	8	within	within	ADP
bam-1791	450	9	muscle	muscle	NOUN
bam-1791	450	10	fibres	fibre	NOUN
bam-1791	450	11	and	and	CCONJ
bam-1791	450	12	its	its	PRON
bam-1791	450	13	possible	possible	ADJ
bam-1791	450	14	consequences	consequence	NOUN
bam-1791	450	15	for	for	ADP
bam-1791	450	16	muscle	muscle	NOUN
bam-1791	450	17	function	function	NOUN
bam-1791	450	18	.	.	PUNCT
bam-1791	451	1	intracellular	intracellular	ADJ
bam-1791	451	2	lipid	lipid	NOUN
bam-1791	451	3	droplets	droplet	NOUN
bam-1791	451	4	are	be	AUX
bam-1791	451	5	associated	associate	VERB
bam-1791	451	6	with	with	ADP
bam-1791	451	7	perilipins	perilipin	NOUN
bam-1791	451	8	(	(	PUNCT
bam-1791	451	9	plins	plin	NOUN
bam-1791	451	10	)	)	PUNCT
bam-1791	451	11	,	,	PUNCT
bam-1791	451	12	proteins	protein	NOUN
bam-1791	451	13	involved	involve	VERB
bam-1791	451	14	in	in	ADP
bam-1791	451	15	lipid	lipid	NOUN
bam-1791	451	16	storage	storage	NOUN
bam-1791	451	17	and	and	CCONJ
bam-1791	451	18	mobilization	mobilization	NOUN
bam-1791	451	19	.	.	PUNCT
bam-1791	452	1	we	we	PRON
bam-1791	452	2	investigated	investigate	VERB
bam-1791	452	3	the	the	DET
bam-1791	452	4	intra	intra	ADJ
bam-1791	452	5	-	-	ADJ
bam-1791	452	6	fibre	fibre	ADJ
bam-1791	452	7	expression	expression	NOUN
bam-1791	452	8	of	of	ADP
bam-1791	452	9	muscle	muscle	NOUN
bam-1791	452	10	-	-	PUNCT
bam-1791	452	11	specific	specific	ADJ
bam-1791	452	12	plin2	plin2	NOUN
bam-1791	452	13	in	in	ADP
bam-1791	452	14	vastus	vastus	NOUN
bam-1791	452	15	lateralis	laterali	NOUN
bam-1791	452	16	of	of	ADP
bam-1791	452	17	subjects	subject	NOUN
bam-1791	452	18	of	of	ADP
bam-1791	452	19	different	different	ADJ
bam-1791	452	20	age	age	NOUN
bam-1791	452	21	,	,	PUNCT
bam-1791	452	22	either	either	CCONJ
bam-1791	452	23	healthy	healthy	ADJ
bam-1791	452	24	or	or	CCONJ
bam-1791	452	25	affected	affect	VERB
bam-1791	452	26	by	by	ADP
bam-1791	452	27	mobility	mobility	NOUN
bam-1791	452	28	-	-	PUNCT
bam-1791	452	29	limitating	limitate	VERB
bam-1791	452	30	pathologies	pathology	NOUN
bam-1791	452	31	(	(	PUNCT
bam-1791	452	32	hip	hip	NOUN
bam-1791	452	33	osteoarthritis	osteoarthritis	NOUN
bam-1791	452	34	)	)	PUNCT
bam-1791	452	35	,	,	PUNCT
bam-1791	452	36	compared	compare	VERB
bam-1791	452	37	with	with	ADP
bam-1791	452	38	the	the	DET
bam-1791	452	39	expression	expression	NOUN
bam-1791	452	40	of	of	ADP
bam-1791	452	41	adipose	adipose	ADJ
bam-1791	452	42	tissue	tissue	NOUN
bam-1791	452	43	-	-	PUNCT
bam-1791	452	44	specific	specific	ADJ
bam-1791	452	45	plin1	plin1	NOUN
bam-1791	452	46	.	.	PUNCT
bam-1791	453	1	plin2	plin2	NOUN
bam-1791	453	2	expression	expression	NOUN
bam-1791	453	3	is	be	AUX
bam-1791	453	4	present	present	ADJ
bam-1791	453	5	in	in	ADP
bam-1791	453	6	both	both	CCONJ
bam-1791	453	7	young	young	ADJ
bam-1791	453	8	and	and	CCONJ
bam-1791	453	9	old	old	ADJ
bam-1791	453	10	subjects	subject	NOUN
bam-1791	453	11	,	,	PUNCT
bam-1791	453	12	increases	increase	NOUN
bam-1791	453	13	with	with	ADP
bam-1791	453	14	age	age	NOUN
bam-1791	453	15	and	and	CCONJ
bam-1791	453	16	is	be	AUX
bam-1791	453	17	particularly	particularly	ADV
bam-1791	453	18	evident	evident	ADJ
bam-1791	453	19	in	in	ADP
bam-1791	453	20	patients	patient	NOUN
bam-1791	453	21	with	with	ADP
bam-1791	453	22	decreased	decrease	VERB
bam-1791	453	23	limb	limb	NOUN
bam-1791	453	24	mobility	mobility	NOUN
bam-1791	453	25	,	,	PUNCT
bam-1791	453	26	where	where	SCONJ
bam-1791	453	27	it	it	PRON
bam-1791	453	28	correlates	correlate	VERB
bam-1791	453	29	with	with	ADP
bam-1791	453	30	muscle	muscle	NOUN
bam-1791	453	31	quality	quality	NOUN
bam-1791	453	32	.	.	PUNCT
bam-1791	454	1	moreover	moreover	ADV
bam-1791	454	2	,	,	PUNCT
bam-1791	454	3	in	in	ADP
bam-1791	454	4	patients	patient	NOUN
bam-1791	454	5	a	a	DET
bam-1791	454	6	direct	direct	ADJ
bam-1791	454	7	correlation	correlation	NOUN
bam-1791	454	8	was	be	AUX
bam-1791	454	9	found	find	VERB
bam-1791	454	10	with	with	ADP
bam-1791	454	11	the	the	DET
bam-1791	454	12	expression	expression	NOUN
bam-1791	454	13	of	of	ADP
bam-1791	454	14	the	the	DET
bam-1791	454	15	main	main	ADJ
bam-1791	454	16	plin2	plin2	NOUN
bam-1791	454	17	transcriptional	transcriptional	ADJ
bam-1791	454	18	regulator	regulator	NOUN
bam-1791	454	19	ppar	ppar	NOUN
bam-1791	454	20	-	-	PUNCT
bam-1791	454	21	γ	γ	NOUN
bam-1791	454	22	and	and	CCONJ
bam-1791	454	23	with	with	ADP
bam-1791	454	24	a	a	DET
bam-1791	454	25	dramatic	dramatic	ADJ
bam-1791	454	26	increase	increase	NOUN
bam-1791	454	27	in	in	ADP
bam-1791	454	28	p53	p53	NOUN
bam-1791	454	29	phosphorylation	phosphorylation	NOUN
bam-1791	454	30	,	,	PUNCT
bam-1791	454	31	a	a	DET
bam-1791	454	32	possible	possible	ADJ
bam-1791	454	33	sign	sign	NOUN
bam-1791	454	34	of	of	ADP
bam-1791	454	35	muscle	muscle	NOUN
bam-1791	454	36	waste	waste	NOUN
bam-1791	454	37	.	.	PUNCT
bam-1791	455	1	these	these	DET
bam-1791	455	2	last	last	ADJ
bam-1791	455	3	changes	change	NOUN
bam-1791	455	4	were	be	AUX
bam-1791	455	5	absent	absent	ADJ
bam-1791	455	6	in	in	ADP
bam-1791	455	7	healthy	healthy	ADJ
bam-1791	455	8	young	young	ADJ
bam-1791	455	9	and	and	CCONJ
bam-1791	455	10	in	in	ADP
bam-1791	455	11	active	active	ADJ
bam-1791	455	12	and	and	CCONJ
bam-1791	455	13	sedentary	sedentary	ADJ
bam-1791	455	14	old	old	ADJ
bam-1791	455	15	subjects	subject	NOUN
bam-1791	455	16	,	,	PUNCT
bam-1791	455	17	where	where	SCONJ
bam-1791	455	18	an	an	DET
bam-1791	455	19	unexpected	unexpected	ADJ
bam-1791	455	20	activation	activation	NOUN
bam-1791	455	21	of	of	ADP
bam-1791	455	22	nf	nf	NOUN
bam-1791	455	23	-	-	PUNCT
bam-1791	455	24	kb	kb	PROPN
bam-1791	455	25	was	be	AUX
bam-1791	455	26	observed	observe	VERB
bam-1791	455	27	.	.	PUNCT
bam-1791	456	1	thus	thus	ADV
bam-1791	456	2	,	,	PUNCT
bam-1791	456	3	beside	beside	ADP
bam-1791	456	4	inter	inter	ADJ
bam-1791	456	5	-	-	ADJ
bam-1791	456	6	fibre	fibre	ADJ
bam-1791	456	7	fat	fat	ADJ
bam-1791	456	8	infiltration	infiltration	NOUN
bam-1791	456	9	,	,	PUNCT
bam-1791	456	10	a	a	DET
bam-1791	456	11	lipid	lipid	NOUN
bam-1791	456	12	deposition	deposition	NOUN
bam-1791	456	13	occurs	occur	VERB
bam-1791	456	14	within	within	ADP
bam-1791	456	15	the	the	DET
bam-1791	456	16	muscle	muscle	NOUN
bam-1791	456	17	fibres	fibre	NOUN
bam-1791	456	18	as	as	ADP
bam-1791	456	19	a	a	DET
bam-1791	456	20	consequence	consequence	NOUN
bam-1791	456	21	of	of	ADP
bam-1791	456	22	inactivity	inactivity	NOUN
bam-1791	456	23	without	without	ADP
bam-1791	456	24	nf	nf	ADJ
bam-1791	456	25	-	-	PUNCT
bam-1791	456	26	kb	kb	NOUN
bam-1791	456	27	activation	activation	NOUN
bam-1791	456	28	,	,	PUNCT
bam-1791	456	29	and	and	CCONJ
bam-1791	456	30	appears	appear	VERB
bam-1791	456	31	to	to	PART
bam-1791	456	32	be	be	AUX
bam-1791	456	33	exacerbated	exacerbate	VERB
bam-1791	456	34	by	by	ADP
bam-1791	456	35	age	age	NOUN
bam-1791	456	36	,	,	PUNCT
bam-1791	456	37	and	and	CCONJ
bam-1791	456	38	correlates	correlate	VERB
bam-1791	456	39	with	with	ADP
bam-1791	456	40	muscle	muscle	NOUN
bam-1791	456	41	weakness	weakness	NOUN
bam-1791	456	42	and	and	CCONJ
bam-1791	456	43	loss	loss	NOUN
bam-1791	456	44	of	of	ADP
bam-1791	456	45	muscle	muscle	NOUN
bam-1791	456	46	quality	quality	NOUN
bam-1791	456	47	.	.	PUNCT
bam-1791	457	1	ix	ix	PROPN
bam-1791	457	2	iim	iim	PROPN
bam-1791	457	3	meeting	meeting	NOUN
bam-1791	457	4	,	,	PUNCT
bam-1791	457	5	acaya	acaya	NOUN
bam-1791	457	6	(	(	PUNCT
bam-1791	457	7	lecce	lecce	PROPN
bam-1791	457	8	)	)	PUNCT
bam-1791	457	9	,	,	PUNCT
bam-1791	457	10	october	october	PROPN
bam-1791	457	11	12	12	NUM
bam-1791	457	12	-	-	SYM
bam-1791	457	13	14	14	NUM
bam-1791	457	14	,	,	PUNCT
bam-1791	457	15	2012	2012	NUM
bam-1791	457	16	european	european	PROPN
bam-1791	457	17	journal	journal	PROPN
bam-1791	457	18	translational	translational	ADJ
bam-1791	457	19	myology	myology	NOUN
bam-1791	457	20	basic	basic	ADJ
bam-1791	457	21	applied	apply	VERB
bam-1791	457	22	myology	myology	NOUN
bam-1791	457	23	2012	2012	NUM
bam-1791	457	24	;	;	PUNCT
bam-1791	457	25	22(1&2	22(1&2	NUM
bam-1791	457	26	):	):	PUNCT
bam-1791	457	27	xxx	xxx	NOUN
bam-1791	457	28	-	-	PUNCT
bam-1791	457	29	xxx	xxx	PROPN
bam-1791	457	30	37	37	NUM
bam-1791	457	31	session	session	NOUN
bam-1791	457	32	7	7	NUM
bam-1791	457	33	cachexia	cachexia	NOUN
bam-1791	457	34	and	and	CCONJ
bam-1791	457	35	muscle	muscle	NOUN
bam-1791	457	36	wasting	waste	VERB
bam-1791	457	37	39	39	NUM
bam-1791	457	38	.	.	PUNCT
bam-1791	458	1	migrating	migrate	VERB
bam-1791	458	2	tumor	tumor	NOUN
bam-1791	458	3	cells	cell	NOUN
bam-1791	458	4	and	and	CCONJ
bam-1791	458	5	muscle	muscle	NOUN
bam-1791	458	6	wasting	waste	VERB
bam-1791	458	7	emanuele	emanuele	PROPN
bam-1791	458	8	berardi1	berardi1	PROPN
bam-1791	458	9	,	,	PUNCT
bam-1791	458	10	marco	marco	PROPN
bam-1791	458	11	cassano	cassano	PROPN
bam-1791	458	12	,	,	PUNCT
bam-1791	458	13	carolina	carolina	PROPN
bam-1791	458	14	ortiz	ortiz	PROPN
bam-1791	458	15	,	,	PUNCT
bam-1791	458	16	domiziana	domiziana	PROPN
bam-1791	458	17	costamagna5	costamagna5	NOUN
bam-1791	458	18	,	,	PUNCT
bam-1791	458	19	giuseppe	giuseppe	PROPN
bam-1791	458	20	floris2	floris2	PROPN
bam-1791	458	21	,	,	PUNCT
bam-1791	458	22	agnieszka	agnieszka	PROPN
bam-1791	458	23	wozniak2	wozniak2	PROPN
bam-1791	458	24	,	,	PUNCT
bam-1791	458	25	maria	maria	PROPN
bam-1791	458	26	debiec	debiec	NOUN
bam-1791	458	27	-	-	PUNCT
bam-1791	458	28	rychter3	rychter3	NOUN
bam-1791	458	29	,	,	PUNCT
bam-1791	458	30	patrick	patrick	PROPN
bam-1791	458	31	schöffscki2	schöffscki2	PROPN
bam-1791	458	32	and	and	CCONJ
bam-1791	458	33	maurilio	maurilio	NOUN
bam-1791	458	34	sampaolesi1,4	sampaolesi1,4	PROPN
bam-1791	458	35	1laboratory	1laboratory	NUM
bam-1791	458	36	of	of	ADP
bam-1791	458	37	translational	translational	ADJ
bam-1791	458	38	cardiomyology	cardiomyology	NOUN
bam-1791	458	39	-	-	PUNCT
bam-1791	458	40	scil	scil	NOUN
bam-1791	458	41	;	;	PUNCT
bam-1791	458	42	2laboratory	2laboratory	NUM
bam-1791	458	43	of	of	ADP
bam-1791	458	44	experimental	experimental	ADJ
bam-1791	458	45	oncology	oncology	NOUN
bam-1791	458	46	and	and	CCONJ
bam-1791	458	47	3human	3human	NUM
bam-1791	458	48	genetics	genetic	NOUN
bam-1791	458	49	,	,	PUNCT
bam-1791	458	50	ku	ku	PROPN
bam-1791	458	51	leuven	leuven	PROPN
bam-1791	458	52	,	,	PUNCT
bam-1791	458	53	belgium	belgium	PROPN
bam-1791	458	54	;	;	PUNCT
bam-1791	458	55	4department	4department	NUM
bam-1791	458	56	of	of	ADP
bam-1791	458	57	public	public	ADJ
bam-1791	458	58	health	health	NOUN
bam-1791	458	59	,	,	PUNCT
bam-1791	458	60	neuroscience	neuroscience	NOUN
bam-1791	458	61	,	,	PUNCT
bam-1791	458	62	experimental	experimental	ADJ
bam-1791	458	63	and	and	CCONJ
bam-1791	458	64	forensic	forensic	ADJ
bam-1791	458	65	medicine	medicine	NOUN
bam-1791	458	66	,	,	PUNCT
bam-1791	458	67	pavia	pavia	PROPN
bam-1791	458	68	,	,	PUNCT
bam-1791	458	69	italy	italy	PROPN
bam-1791	458	70	;	;	PUNCT
bam-1791	458	71	5departement	5departement	NUM
bam-1791	458	72	of	of	ADP
bam-1791	458	73	experimental	experimental	ADJ
bam-1791	458	74	medicine	medicine	NOUN
bam-1791	458	75	and	and	CCONJ
bam-1791	458	76	oncology	oncology	NOUN
bam-1791	458	77	,	,	PUNCT
bam-1791	458	78	university	university	PROPN
bam-1791	458	79	of	of	ADP
bam-1791	458	80	turin	turin	PROPN
bam-1791	458	81	,	,	PUNCT
bam-1791	458	82	italy	italy	PROPN
bam-1791	458	83	.	.	PUNCT
bam-1791	459	1	cachexia	cachexia	PROPN
bam-1791	459	2	is	be	AUX
bam-1791	459	3	a	a	DET
bam-1791	459	4	syndrome	syndrome	NOUN
bam-1791	459	5	characterized	characterize	VERB
bam-1791	459	6	by	by	ADP
bam-1791	459	7	progressive	progressive	ADJ
bam-1791	459	8	weight	weight	NOUN
bam-1791	459	9	loss	loss	NOUN
bam-1791	459	10	with	with	ADP
bam-1791	459	11	depletion	depletion	NOUN
bam-1791	459	12	of	of	ADP
bam-1791	459	13	lean	lean	ADJ
bam-1791	459	14	body	body	NOUN
bam-1791	459	15	mass	mass	NOUN
bam-1791	459	16	and	and	CCONJ
bam-1791	459	17	muscle	muscle	NOUN
bam-1791	459	18	,	,	PUNCT
bam-1791	459	19	which	which	PRON
bam-1791	459	20	occurs	occur	VERB
bam-1791	459	21	in	in	ADP
bam-1791	459	22	the	the	DET
bam-1791	459	23	presence	presence	NOUN
bam-1791	459	24	of	of	ADP
bam-1791	459	25	underlying	underlie	VERB
bam-1791	459	26	illness	illness	NOUN
bam-1791	459	27	.	.	PUNCT
bam-1791	460	1	it	it	PRON
bam-1791	460	2	is	be	AUX
bam-1791	460	3	reported	report	VERB
bam-1791	460	4	in	in	ADP
bam-1791	460	5	patients	patient	NOUN
bam-1791	460	6	with	with	ADP
bam-1791	460	7	several	several	ADJ
bam-1791	460	8	chronic	chronic	ADJ
bam-1791	460	9	diseases	disease	NOUN
bam-1791	460	10	,	,	PUNCT
bam-1791	460	11	including	include	VERB
bam-1791	460	12	cancer	cancer	NOUN
bam-1791	460	13	.	.	PUNCT
bam-1791	461	1	the	the	DET
bam-1791	461	2	prevalence	prevalence	NOUN
bam-1791	461	3	of	of	ADP
bam-1791	461	4	cachexia	cachexia	NOUN
bam-1791	461	5	among	among	ADP
bam-1791	461	6	patients	patient	NOUN
bam-1791	461	7	affected	affect	VERB
bam-1791	461	8	by	by	ADP
bam-1791	461	9	different	different	ADJ
bam-1791	461	10	diseases	disease	NOUN
bam-1791	461	11	varies	vary	VERB
bam-1791	461	12	accordingly	accordingly	ADV
bam-1791	461	13	to	to	ADP
bam-1791	461	14	the	the	DET
bam-1791	461	15	nature	nature	NOUN
bam-1791	461	16	of	of	ADP
bam-1791	461	17	the	the	DET
bam-1791	461	18	specific	specific	ADJ
bam-1791	461	19	chronic	chronic	ADJ
bam-1791	461	20	illness	illness	NOUN
bam-1791	461	21	.	.	PUNCT
bam-1791	462	1	cachexia	cachexia	PROPN
bam-1791	462	2	syndrome	syndrome	PROPN
bam-1791	462	3	directly	directly	ADV
bam-1791	462	4	accounts	account	VERB
bam-1791	462	5	for	for	ADP
bam-1791	462	6	the	the	DET
bam-1791	462	7	death	death	NOUN
bam-1791	462	8	of	of	ADP
bam-1791	462	9	20	20	NUM
bam-1791	462	10	%	%	NOUN
bam-1791	462	11	of	of	ADP
bam-1791	462	12	cancer	cancer	NOUN
bam-1791	462	13	patients	patient	NOUN
bam-1791	462	14	.	.	PUNCT
bam-1791	463	1	selective	selective	ADJ
bam-1791	463	2	skeletal	skeletal	ADJ
bam-1791	463	3	muscle	muscle	NOUN
bam-1791	463	4	wasting	waste	VERB
bam-1791	463	5	is	be	AUX
bam-1791	463	6	a	a	DET
bam-1791	463	7	main	main	ADJ
bam-1791	463	8	pathological	pathological	ADJ
bam-1791	463	9	feature	feature	NOUN
bam-1791	463	10	exhibited	exhibit	VERB
bam-1791	463	11	in	in	ADP
bam-1791	463	12	cancer	cancer	NOUN
bam-1791	463	13	,	,	PUNCT
bam-1791	463	14	and	and	CCONJ
bam-1791	463	15	reflects	reflect	VERB
bam-1791	463	16	an	an	DET
bam-1791	463	17	imbalance	imbalance	NOUN
bam-1791	463	18	between	between	ADP
bam-1791	463	19	protein	protein	NOUN
bam-1791	463	20	synthesis	synthesis	NOUN
bam-1791	463	21	and	and	CCONJ
bam-1791	463	22	catabolism	catabolism	NOUN
bam-1791	463	23	.	.	PUNCT
bam-1791	464	1	several	several	ADJ
bam-1791	464	2	studies	study	NOUN
bam-1791	464	3	indicate	indicate	VERB
bam-1791	464	4	four	four	NUM
bam-1791	464	5	main	main	ADJ
bam-1791	464	6	pathways	pathway	NOUN
bam-1791	464	7	as	as	ADP
bam-1791	464	8	responsible	responsible	ADJ
bam-1791	464	9	for	for	ADP
bam-1791	464	10	skeletal	skeletal	ADJ
bam-1791	464	11	muscle	muscle	NOUN
bam-1791	464	12	catabolism	catabolism	NOUN
bam-1791	464	13	:	:	PUNCT
bam-1791	464	14	the	the	DET
bam-1791	464	15	ubiquitin	ubiquitin	NOUN
bam-1791	464	16	–	–	PUNCT
bam-1791	464	17	proteasome	proteasome	NOUN
bam-1791	464	18	pathway	pathway	NOUN
bam-1791	464	19	(	(	PUNCT
bam-1791	464	20	upp	upp	PROPN
bam-1791	464	21	)	)	PUNCT
bam-1791	464	22	,	,	PUNCT
bam-1791	464	23	protease	protease	NOUN
bam-1791	464	24	-	-	PUNCT
bam-1791	464	25	mediated	mediate	VERB
bam-1791	464	26	degradation	degradation	NOUN
bam-1791	464	27	,	,	PUNCT
bam-1791	464	28	autophagocytosis	autophagocytosis	NOUN
bam-1791	464	29	and	and	CCONJ
bam-1791	464	30	inflammation	inflammation	NOUN
bam-1791	464	31	.	.	PUNCT
bam-1791	465	1	to	to	ADP
bam-1791	465	2	date	date	NOUN
bam-1791	465	3	these	these	DET
bam-1791	465	4	pathways	pathway	NOUN
bam-1791	465	5	has	have	AUX
bam-1791	465	6	been	be	AUX
bam-1791	465	7	deeply	deeply	ADV
bam-1791	465	8	investigated	investigate	VERB
bam-1791	465	9	,	,	PUNCT
bam-1791	465	10	suggesting	suggest	VERB
bam-1791	465	11	that	that	SCONJ
bam-1791	465	12	the	the	DET
bam-1791	465	13	regulation	regulation	NOUN
bam-1791	465	14	of	of	ADP
bam-1791	465	15	these	these	DET
bam-1791	465	16	cellular	cellular	ADJ
bam-1791	465	17	processes	process	NOUN
bam-1791	465	18	take	take	VERB
bam-1791	465	19	place	place	NOUN
bam-1791	465	20	mainly	mainly	ADV
bam-1791	465	21	within	within	ADP
bam-1791	465	22	the	the	DET
bam-1791	465	23	myofiber	myofiber	NOUN
bam-1791	465	24	niche1	niche1	NOUN
bam-1791	465	25	.	.	PUNCT
bam-1791	466	1	recently	recently	ADV
bam-1791	466	2	,	,	PUNCT
bam-1791	466	3	we	we	PRON
bam-1791	466	4	and	and	CCONJ
bam-1791	466	5	other	other	ADJ
bam-1791	466	6	laboratories	laboratory	NOUN
bam-1791	466	7	obtained	obtain	VERB
bam-1791	466	8	several	several	ADJ
bam-1791	466	9	data	datum	NOUN
bam-1791	466	10	showing	show	VERB
bam-1791	466	11	that	that	SCONJ
bam-1791	466	12	human	human	ADJ
bam-1791	466	13	tumor	tumor	NOUN
bam-1791	466	14	cells	cell	NOUN
bam-1791	466	15	can	can	AUX
bam-1791	466	16	be	be	AUX
bam-1791	466	17	fused	fuse	VERB
bam-1791	466	18	with	with	ADP
bam-1791	466	19	myoblasts	myoblast	NOUN
bam-1791	466	20	into	into	ADP
bam-1791	466	21	myotubes	myotube	NOUN
bam-1791	466	22	and	and	CCONJ
bam-1791	466	23	myofibers	myofiber	NOUN
bam-1791	466	24	.	.	PUNCT
bam-1791	467	1	in	in	ADP
bam-1791	467	2	this	this	DET
bam-1791	467	3	study	study	NOUN
bam-1791	467	4	we	we	PRON
bam-1791	467	5	aim	aim	VERB
bam-1791	467	6	to	to	PART
bam-1791	467	7	deeply	deeply	ADV
bam-1791	467	8	investigate	investigate	VERB
bam-1791	467	9	the	the	DET
bam-1791	467	10	possible	possible	ADJ
bam-1791	467	11	contribution	contribution	NOUN
bam-1791	467	12	of	of	ADP
bam-1791	467	13	migrating	migrate	VERB
bam-1791	467	14	tumor	tumor	NOUN
bam-1791	467	15	cells	cell	NOUN
bam-1791	467	16	to	to	ADP
bam-1791	467	17	cancer	cancer	NOUN
bam-1791	467	18	-	-	PUNCT
bam-1791	467	19	induced	induce	VERB
bam-1791	467	20	cachexia	cachexia	NOUN
bam-1791	467	21	.	.	PUNCT
bam-1791	468	1	in	in	ADP
bam-1791	468	2	particular	particular	ADJ
bam-1791	468	3	,	,	PUNCT
bam-1791	468	4	we	we	PRON
bam-1791	468	5	used	use	VERB
bam-1791	468	6	both	both	CCONJ
bam-1791	468	7	in	in	ADP
bam-1791	468	8	vitro	vitro	X
bam-1791	468	9	cell	cell	NOUN
bam-1791	468	10	system	system	NOUN
bam-1791	468	11	and	and	CCONJ
bam-1791	468	12	xenograft	xenograft	NOUN
bam-1791	468	13	animal	animal	NOUN
bam-1791	468	14	models	model	NOUN
bam-1791	468	15	obtained	obtain	VERB
bam-1791	468	16	by	by	ADP
bam-1791	468	17	subcutaneous	subcutaneous	ADJ
bam-1791	468	18	injection	injection	NOUN
bam-1791	468	19	of	of	ADP
bam-1791	468	20	human	human	ADJ
bam-1791	468	21	gastrointestinal	gastrointestinal	ADJ
bam-1791	468	22	tumor	tumor	NOUN
bam-1791	468	23	cells	cell	NOUN
bam-1791	468	24	in	in	ADP
bam-1791	468	25	nude	nude	ADJ
bam-1791	468	26	mice	mouse	NOUN
bam-1791	468	27	.	.	PUNCT
bam-1791	469	1	we	we	PRON
bam-1791	469	2	provided	provide	VERB
bam-1791	469	3	evidences	evidence	NOUN
bam-1791	469	4	for	for	ADP
bam-1791	469	5	a	a	DET
bam-1791	469	6	novel	novel	ADJ
bam-1791	469	7	mechanism	mechanism	NOUN
bam-1791	469	8	by	by	ADP
bam-1791	469	9	which	which	PRON
bam-1791	469	10	migrating	migrate	VERB
bam-1791	469	11	cancer	cancer	NOUN
bam-1791	469	12	cells	cell	NOUN
bam-1791	469	13	are	be	AUX
bam-1791	469	14	directly	directly	ADV
bam-1791	469	15	involved	involve	VERB
bam-1791	469	16	in	in	ADP
bam-1791	469	17	muscle	muscle	NOUN
bam-1791	469	18	atrophy	atrophy	NOUN
bam-1791	469	19	.	.	PUNCT
bam-1791	470	1	references	reference	NOUN
bam-1791	470	2	1glass	1glass	NUM
bam-1791	470	3	,	,	PUNCT
bam-1791	470	4	d.j	d.j	PROPN
bam-1791	470	5	.	.	PROPN
bam-1791	470	6	signaling	signal	VERB
bam-1791	470	7	pathways	pathway	NOUN
bam-1791	470	8	perturbing	perturb	VERB
bam-1791	470	9	muscle	muscle	NOUN
bam-1791	470	10	mass	mass	PROPN
bam-1791	470	11	.	.	PUNCT
bam-1791	471	1	curr	curr	PROPN
bam-1791	471	2	opin	opin	PROPN
bam-1791	471	3	clin	clin	PROPN
bam-1791	471	4	nutr	nutr	PROPN
bam-1791	471	5	metab	metab	PROPN
bam-1791	471	6	care	care	NOUN
bam-1791	471	7	13	13	NUM
bam-1791	471	8	:	:	SYM
bam-1791	471	9	225	225	NUM
bam-1791	471	10	-	-	SYM
bam-1791	471	11	229	229	NUM
bam-1791	471	12	,	,	PUNCT
bam-1791	471	13	2010	2010	NUM
bam-1791	471	14	.	.	PUNCT
bam-1791	472	1	40	40	NUM
bam-1791	472	2	.	.	PUNCT
bam-1791	472	3	caveolins	caveolin	NOUN
bam-1791	472	4	and	and	CCONJ
bam-1791	472	5	cavins	cavin	NOUN
bam-1791	472	6	in	in	ADP
bam-1791	472	7	muscle	muscle	NOUN
bam-1791	472	8	-	-	PUNCT
bam-1791	472	9	derived	derive	VERB
bam-1791	472	10	tumours	tumours	NOUN
bam-1791	472	11	fiorella	fiorella	X
bam-1791	472	12	faggi	faggi	ADJ
bam-1791	472	13	1	1	NUM
bam-1791	472	14	,	,	PUNCT
bam-1791	472	15	alessandra	alessandra	PROPN
bam-1791	472	16	zanola	zanola	PROPN
bam-1791	472	17	1	1	NUM
bam-1791	472	18	,	,	PUNCT
bam-1791	472	19	guglielmo	guglielmo	PROPN
bam-1791	472	20	sorci	sorci	VERB
bam-1791	472	21	2	2	NUM
bam-1791	472	22	,	,	PUNCT
bam-1791	472	23	francesca	francesca	PROPN
bam-1791	472	24	riuzzi	riuzzi	NOUN
bam-1791	472	25	2	2	NUM
bam-1791	472	26	,	,	PUNCT
bam-1791	472	27	silvia	silvia	PROPN
bam-1791	472	28	codenotti	codenotti	PROPN
bam-1791	472	29	1	1	NUM
bam-1791	472	30	,	,	PUNCT
bam-1791	472	31	eugenio	eugenio	PROPN
bam-1791	472	32	monti	monti	PROPN
bam-1791	472	33	1	1	NUM
bam-1791	472	34	,	,	PUNCT
bam-1791	472	35	alessandro	alessandro	PROPN
bam-1791	472	36	fanzani	fanzani	ADJ
bam-1791	472	37	1	1	NUM
bam-1791	472	38	1	1	NUM
bam-1791	472	39	department	department	NOUN
bam-1791	472	40	of	of	ADP
bam-1791	472	41	molecular	molecular	ADJ
bam-1791	472	42	and	and	CCONJ
bam-1791	472	43	translational	translational	ADJ
bam-1791	472	44	medicine	medicine	NOUN
bam-1791	472	45	and	and	CCONJ
bam-1791	472	46	iim	iim	NOUN
bam-1791	472	47	,	,	PUNCT
bam-1791	472	48	university	university	NOUN
bam-1791	472	49	of	of	ADP
bam-1791	472	50	brescia	brescia	PROPN
bam-1791	472	51	,	,	PUNCT
bam-1791	472	52	italy	italy	PROPN
bam-1791	472	53	.	.	PROPN
bam-1791	473	1	2	2	NUM
bam-1791	473	2	department	department	NOUN
bam-1791	473	3	of	of	ADP
bam-1791	473	4	experimental	experimental	ADJ
bam-1791	473	5	medicine	medicine	NOUN
bam-1791	473	6	and	and	CCONJ
bam-1791	473	7	biochemical	biochemical	ADJ
bam-1791	473	8	sciences	science	NOUN
bam-1791	473	9	and	and	CCONJ
bam-1791	473	10	interuniversitary	interuniversitary	PROPN
bam-1791	473	11	institute	institute	PROPN
bam-1791	473	12	of	of	ADP
bam-1791	473	13	myology	myology	NOUN
bam-1791	473	14	(	(	PUNCT
bam-1791	473	15	iim	iim	NOUN
bam-1791	473	16	)	)	PUNCT
bam-1791	473	17	,	,	PUNCT
bam-1791	473	18	university	university	NOUN
bam-1791	473	19	of	of	ADP
bam-1791	473	20	perugia	perugia	PROPN
bam-1791	473	21	,	,	PUNCT
bam-1791	473	22	italy	italy	PROPN
bam-1791	473	23	.	.	PUNCT
bam-1791	474	1	rhabdomyosarcomas	rhabdomyosarcomas	PROPN
bam-1791	474	2	(	(	PUNCT
bam-1791	474	3	rms	rm	NOUN
bam-1791	474	4	)	)	PUNCT
bam-1791	474	5	are	be	AUX
bam-1791	474	6	muscle	muscle	NOUN
bam-1791	474	7	-	-	PUNCT
bam-1791	474	8	derived	derive	VERB
bam-1791	474	9	tumours	tumour	NOUN
bam-1791	474	10	with	with	ADP
bam-1791	474	11	a	a	DET
bam-1791	474	12	significant	significant	ADJ
bam-1791	474	13	incidence	incidence	NOUN
bam-1791	474	14	in	in	ADP
bam-1791	474	15	children	child	NOUN
bam-1791	474	16	.	.	PUNCT
bam-1791	475	1	rms	rm	NOUN
bam-1791	475	2	cells	cell	NOUN
bam-1791	475	3	exhibit	exhibit	VERB
bam-1791	475	4	a	a	DET
bam-1791	475	5	widespread	widespread	ADJ
bam-1791	475	6	pattern	pattern	NOUN
bam-1791	475	7	of	of	ADP
bam-1791	475	8	muscle	muscle	NOUN
bam-1791	475	9	-	-	PUNCT
bam-1791	475	10	specific	specific	ADJ
bam-1791	475	11	markers	marker	NOUN
bam-1791	475	12	,	,	PUNCT
bam-1791	475	13	the	the	DET
bam-1791	475	14	detection	detection	NOUN
bam-1791	475	15	of	of	ADP
bam-1791	475	16	which	which	PRON
bam-1791	475	17	may	may	AUX
bam-1791	475	18	be	be	AUX
bam-1791	475	19	useful	useful	ADJ
bam-1791	475	20	for	for	ADP
bam-1791	475	21	discriminating	discriminate	VERB
bam-1791	475	22	the	the	DET
bam-1791	475	23	tumour	tumour	NOUN
bam-1791	475	24	grading	grading	NOUN
bam-1791	475	25	in	in	ADP
bam-1791	475	26	order	order	NOUN
bam-1791	475	27	to	to	PART
bam-1791	475	28	optimize	optimize	VERB
bam-1791	475	29	the	the	DET
bam-1791	475	30	timing	timing	NOUN
bam-1791	475	31	and	and	CCONJ
bam-1791	475	32	doses	dose	NOUN
bam-1791	475	33	of	of	ADP
bam-1791	475	34	chemotherapy	chemotherapy	NOUN
bam-1791	475	35	.	.	PUNCT
bam-1791	476	1	by	by	ADP
bam-1791	476	2	analyzing	analyze	VERB
bam-1791	476	3	human	human	ADJ
bam-1791	476	4	rms	rm	NOUN
bam-1791	476	5	specimens	specimen	NOUN
bam-1791	476	6	and	and	CCONJ
bam-1791	476	7	in	in	ADP
bam-1791	476	8	vitro	vitro	X
bam-1791	476	9	cell	cell	NOUN
bam-1791	476	10	lines	line	NOUN
bam-1791	476	11	,	,	PUNCT
bam-1791	476	12	we	we	PRON
bam-1791	476	13	determined	determine	VERB
bam-1791	476	14	the	the	DET
bam-1791	476	15	time	time	NOUN
bam-1791	476	16	window	window	NOUN
bam-1791	476	17	of	of	ADP
bam-1791	476	18	expression	expression	NOUN
bam-1791	476	19	of	of	ADP
bam-1791	476	20	caveolins	caveolin	NOUN
bam-1791	476	21	(	(	PUNCT
bam-1791	476	22	cav-1	cav-1	NOUN
bam-1791	476	23	,	,	PUNCT
bam-1791	476	24	-2	-2	NOUN
bam-1791	476	25	and	and	CCONJ
bam-1791	476	26	-3	-3	PUNCT
bam-1791	476	27	)	)	PUNCT
bam-1791	476	28	and	and	CCONJ
bam-1791	476	29	some	some	DET
bam-1791	476	30	cavins	cavin	NOUN
bam-1791	476	31	family	family	NOUN
bam-1791	476	32	members	member	NOUN
bam-1791	476	33	(	(	PUNCT
bam-1791	476	34	i.e.	i.e.	X
bam-1791	476	35	ptrf	ptrf	NOUN
bam-1791	476	36	/	/	SYM
bam-1791	476	37	cavin-1	cavin-1	NUM
bam-1791	476	38	and	and	CCONJ
bam-1791	476	39	murc	murc	PROPN
bam-1791	476	40	/	/	SYM
bam-1791	476	41	cavin-4	cavin-4	NOUN
bam-1791	476	42	)	)	PUNCT
bam-1791	476	43	.	.	PUNCT
bam-1791	477	1	in	in	ADP
bam-1791	477	2	detail	detail	NOUN
bam-1791	477	3	,	,	PUNCT
bam-1791	477	4	the	the	DET
bam-1791	477	5	simultaneous	simultaneous	ADJ
bam-1791	477	6	expression	expression	NOUN
bam-1791	477	7	of	of	ADP
bam-1791	477	8	cav-1	cav-1	ADJ
bam-1791	477	9	,	,	PUNCT
bam-1791	477	10	cav-2	cav-2	PUNCT
bam-1791	477	11	and	and	CCONJ
bam-1791	477	12	ptrf	ptrf	ADV
bam-1791	477	13	/	/	SYM
bam-1791	478	1	cavin-1	cavin-1	NUM
bam-1791	478	2	defined	define	VERB
bam-1791	478	3	a	a	DET
bam-1791	478	4	signature	signature	NOUN
bam-1791	478	5	predictive	predictive	NOUN
bam-1791	478	6	of	of	ADP
bam-1791	478	7	immature	immature	ADJ
bam-1791	478	8	cells	cell	NOUN
bam-1791	478	9	,	,	PUNCT
bam-1791	478	10	whereas	whereas	SCONJ
bam-1791	478	11	the	the	DET
bam-1791	478	12	expression	expression	NOUN
bam-1791	478	13	of	of	ADP
bam-1791	478	14	cav-3	cav-3	NOUN
bam-1791	478	15	and	and	CCONJ
bam-1791	478	16	murc	murc	PROPN
bam-1791	478	17	/	/	SYM
bam-1791	478	18	cavin-4	cavin-4	PROPN
bam-1791	478	19	was	be	AUX
bam-1791	478	20	restricted	restrict	VERB
bam-1791	478	21	to	to	ADP
bam-1791	478	22	more	more	ADV
bam-1791	478	23	differentiated	differentiated	ADJ
bam-1791	478	24	cells	cell	NOUN
bam-1791	478	25	.	.	PUNCT
bam-1791	479	1	in	in	ADP
bam-1791	479	2	addition	addition	NOUN
bam-1791	479	3	,	,	PUNCT
bam-1791	479	4	in	in	ADP
bam-1791	479	5	immature	immature	ADJ
bam-1791	479	6	cells	cell	NOUN
bam-1791	479	7	cav-1	cav-1	PUNCT
bam-1791	479	8	was	be	AUX
bam-1791	479	9	tyrosine	tyrosine	NOUN
bam-1791	479	10	-	-	PUNCT
bam-1791	479	11	phosphorylated	phosphorylate	VERB
bam-1791	479	12	in	in	ADP
bam-1791	479	13	a	a	DET
bam-1791	479	14	srcdependent	srcdependent	NOUN
bam-1791	479	15	manner	manner	NOUN
bam-1791	479	16	,	,	PUNCT
bam-1791	479	17	resulting	result	VERB
bam-1791	479	18	in	in	ADP
bam-1791	479	19	increased	increase	VERB
bam-1791	479	20	cell	cell	NOUN
bam-1791	479	21	proliferation	proliferation	NOUN
bam-1791	479	22	and	and	CCONJ
bam-1791	479	23	migration	migration	NOUN
bam-1791	479	24	.	.	PUNCT
bam-1791	480	1	as	as	ADP
bam-1791	480	2	a	a	DET
bam-1791	480	3	result	result	NOUN
bam-1791	480	4	,	,	PUNCT
bam-1791	480	5	the	the	DET
bam-1791	480	6	subcutaneous	subcutaneous	ADJ
bam-1791	480	7	injections	injection	NOUN
bam-1791	480	8	into	into	ADP
bam-1791	480	9	nude	nude	ADJ
bam-1791	480	10	mice	mouse	NOUN
bam-1791	480	11	of	of	ADP
bam-1791	480	12	rms	rm	NOUN
bam-1791	480	13	cells	cell	NOUN
bam-1791	480	14	overexpressing	overexpresse	VERB
bam-1791	480	15	the	the	DET
bam-1791	480	16	wild	wild	ADJ
bam-1791	480	17	-	-	PUNCT
bam-1791	480	18	type	type	NOUN
bam-1791	480	19	cav-1	cav-1	PUNCT
bam-1791	480	20	form	form	NOUN
bam-1791	480	21	resulted	result	VERB
bam-1791	480	22	in	in	ADP
bam-1791	480	23	a	a	DET
bam-1791	480	24	significant	significant	ADJ
bam-1791	480	25	tumour	tumour	NOUN
bam-1791	480	26	growth	growth	NOUN
bam-1791	480	27	,	,	PUNCT
bam-1791	480	28	which	which	PRON
bam-1791	480	29	was	be	AUX
bam-1791	480	30	instead	instead	ADV
bam-1791	480	31	prevented	prevent	VERB
bam-1791	480	32	by	by	ADP
bam-1791	480	33	the	the	DET
bam-1791	480	34	over	over	NOUN
bam-1791	480	35	-	-	PUNCT
bam-1791	480	36	expression	expression	NOUN
bam-1791	480	37	of	of	ADP
bam-1791	480	38	a	a	DET
bam-1791	480	39	non	non	ADJ
bam-1791	480	40	-	-	ADJ
bam-1791	480	41	phosphorylatable	phosphorylatable	ADJ
bam-1791	480	42	form	form	NOUN
bam-1791	480	43	of	of	ADP
bam-1791	480	44	cav-1	cav-1	NOUN
bam-1791	480	45	.	.	PUNCT
bam-1791	481	1	overall	overall	ADV
bam-1791	481	2	,	,	PUNCT
bam-1791	481	3	it	it	PRON
bam-1791	481	4	can	can	AUX
bam-1791	481	5	be	be	AUX
bam-1791	481	6	concluded	conclude	VERB
bam-1791	481	7	that	that	SCONJ
bam-1791	481	8	caveolins	caveolin	NOUN
bam-1791	481	9	and	and	CCONJ
bam-1791	481	10	cavins	cavin	NOUN
bam-1791	481	11	can	can	AUX
bam-1791	481	12	be	be	AUX
bam-1791	481	13	useful	useful	ADJ
bam-1791	481	14	to	to	PART
bam-1791	481	15	identify	identify	VERB
bam-1791	481	16	the	the	DET
bam-1791	481	17	degree	degree	NOUN
bam-1791	481	18	of	of	ADP
bam-1791	481	19	cellular	cellular	ADJ
bam-1791	481	20	differentiation	differentiation	NOUN
bam-1791	481	21	in	in	ADP
bam-1791	481	22	rms	rm	NOUN
bam-1791	481	23	and	and	CCONJ
bam-1791	481	24	that	that	DET
bam-1791	481	25	phosphorylation	phosphorylation	NOUN
bam-1791	481	26	of	of	ADP
bam-1791	481	27	cav-1	cav-1	ADJ
bam-1791	481	28	,	,	PUNCT
bam-1791	481	29	in	in	ADP
bam-1791	481	30	particular	particular	ADJ
bam-1791	481	31	,	,	PUNCT
bam-1791	481	32	plays	play	VERB
bam-1791	481	33	a	a	DET
bam-1791	481	34	key	key	ADJ
bam-1791	481	35	role	role	NOUN
bam-1791	481	36	in	in	ADP
bam-1791	481	37	tumour	tumour	ADJ
bam-1791	481	38	aggressiveness	aggressiveness	NOUN
bam-1791	481	39	.	.	PUNCT
bam-1791	482	1	41	41	NUM
bam-1791	482	2	.	.	PUNCT
bam-1791	483	1	impairment	impairment	NOUN
bam-1791	483	2	of	of	ADP
bam-1791	483	3	myogenic	myogenic	ADJ
bam-1791	483	4	markers	marker	NOUN
bam-1791	483	5	in	in	ADP
bam-1791	483	6	human	human	ADJ
bam-1791	483	7	muscle	muscle	NOUN
bam-1791	483	8	wasting	waste	VERB
bam-1791	483	9	f.	f.	PROPN
bam-1791	483	10	pin1	pin1	PROPN
bam-1791	483	11	,	,	PUNCT
bam-1791	483	12	a.	a.	NOUN
bam-1791	483	13	camperi1	camperi1	PROPN
bam-1791	483	14	,	,	PUNCT
bam-1791	483	15	m.	m.	NOUN
bam-1791	483	16	sturma2	sturma2	PROPN
bam-1791	483	17	,	,	PUNCT
bam-1791	483	18	s.	s.	PROPN
bam-1791	483	19	mazzucco2	mazzucco2	PROPN
bam-1791	483	20	,	,	PUNCT
bam-1791	483	21	f.	f.	PROPN
bam-1791	483	22	penna1	penna1	PROPN
bam-1791	483	23	,	,	PUNCT
bam-1791	483	24	g.	g.	PROPN
bam-1791	483	25	vuolo3	vuolo3	PROPN
bam-1791	483	26	,	,	PUNCT
bam-1791	483	27	m.	m.	PROPN
bam-1791	483	28	muscaritoli4	muscaritoli4	PROPN
bam-1791	483	29	,	,	PUNCT
bam-1791	483	30	f.	f.	PROPN
bam-1791	483	31	rossi	rossi	PROPN
bam-1791	484	1	fanelli4	fanelli4	PROPN
bam-1791	484	2	,	,	PUNCT
bam-1791	484	3	g.	g.	PROPN
bam-1791	484	4	biolo2	biolo2	PROPN
bam-1791	484	5	,	,	PUNCT
bam-1791	484	6	p.	p.	NOUN
bam-1791	484	7	costelli1	costelli1	NOUN
bam-1791	485	1	ix	ix	ADP
bam-1791	485	2	iim	iim	PROPN
bam-1791	485	3	meeting	meeting	NOUN
bam-1791	485	4	,	,	PUNCT
bam-1791	485	5	acaya	acaya	NOUN
bam-1791	485	6	(	(	PUNCT
bam-1791	485	7	lecce	lecce	PROPN
bam-1791	485	8	)	)	PUNCT
bam-1791	485	9	,	,	PUNCT
bam-1791	485	10	october	october	PROPN
bam-1791	485	11	12	12	NUM
bam-1791	485	12	-	-	SYM
bam-1791	485	13	14	14	NUM
bam-1791	485	14	,	,	PUNCT
bam-1791	485	15	2012	2012	NUM
bam-1791	485	16	european	european	PROPN
bam-1791	485	17	journal	journal	PROPN
bam-1791	485	18	translational	translational	ADJ
bam-1791	485	19	myology	myology	NOUN
bam-1791	485	20	basic	basic	ADJ
bam-1791	485	21	applied	apply	VERB
bam-1791	485	22	myology	myology	NOUN
bam-1791	485	23	2012	2012	NUM
bam-1791	485	24	;	;	PUNCT
bam-1791	485	25	22(1&2	22(1&2	NUM
bam-1791	485	26	):	):	PUNCT
bam-1791	485	27	xxx	xxx	NOUN
bam-1791	485	28	-	-	PUNCT
bam-1791	485	29	xxx	xxx	NOUN
bam-1791	485	30	38	38	NUM
bam-1791	485	31	1dipartimento	1dipartimento	NUM
bam-1791	485	32	di	di	X
bam-1791	485	33	medicina	medicina	PROPN
bam-1791	485	34	e	e	PROPN
bam-1791	485	35	oncologia	oncologia	PROPN
bam-1791	485	36	sperimentale	sperimentale	NOUN
bam-1791	485	37	,	,	PUNCT
bam-1791	485	38	università	università	PROPN
bam-1791	485	39	di	di	PROPN
bam-1791	485	40	torino	torino	PROPN
bam-1791	485	41	;	;	PUNCT
bam-1791	485	42	2dipartimento	2dipartimento	NUM
bam-1791	485	43	clinico	clinico	NOUN
bam-1791	485	44	di	di	X
bam-1791	485	45	scienze	scienze	PROPN
bam-1791	485	46	mediche	mediche	PROPN
bam-1791	485	47	,	,	PUNCT
bam-1791	485	48	chirurgiche	chirurgiche	PROPN
bam-1791	485	49	e	e	PROPN
bam-1791	485	50	della	della	NOUN
bam-1791	485	51	salute	salute	NOUN
bam-1791	485	52	,	,	PUNCT
bam-1791	485	53	università	università	PROPN
bam-1791	485	54	di	di	PROPN
bam-1791	485	55	trieste	trieste	PROPN
bam-1791	485	56	;	;	PUNCT
bam-1791	485	57	u.o.c	u.o.c	ADJ
bam-1791	485	58	.	.	PROPN
bam-1791	485	59	di	di	PROPN
bam-1791	485	60	chirurgia	chirurgia	PROPN
bam-1791	485	61	2	2	NUM
bam-1791	485	62	,	,	PUNCT
bam-1791	485	63	3policlinico	3policlinico	NUM
bam-1791	485	64	le	le	X
bam-1791	485	65	scotte	scotte	NOUN
bam-1791	485	66	,	,	PUNCT
bam-1791	485	67	siena	siena	PROPN
bam-1791	485	68	;	;	PUNCT
bam-1791	485	69	4dipartimento	4dipartimento	NUM
bam-1791	485	70	di	di	PROPN
bam-1791	485	71	clinica	clinica	PROPN
bam-1791	485	72	medica	medica	PROPN
bam-1791	485	73	,	,	PUNCT
bam-1791	485	74	'	'	PUNCT
bam-1791	485	75	sapienza	sapienza	NOUN
bam-1791	485	76	'	'	PART
bam-1791	485	77	università	università	PROPN
bam-1791	485	78	di	di	PROPN
bam-1791	485	79	roma	roma	PROPN
bam-1791	485	80	.	.	PUNCT
bam-1791	486	1	the	the	DET
bam-1791	486	2	present	present	ADJ
bam-1791	486	3	study	study	NOUN
bam-1791	486	4	investigated	investigate	VERB
bam-1791	486	5	the	the	DET
bam-1791	486	6	relationship	relationship	NOUN
bam-1791	486	7	between	between	ADP
bam-1791	486	8	prolonged	prolonged	ADJ
bam-1791	486	9	muscle	muscle	NOUN
bam-1791	486	10	immobilization	immobilization	NOUN
bam-1791	486	11	and	and	CCONJ
bam-1791	486	12	gene	gene	NOUN
bam-1791	486	13	expression	expression	NOUN
bam-1791	486	14	of	of	ADP
bam-1791	486	15	myogenic	myogenic	ADJ
bam-1791	486	16	factors	factor	NOUN
bam-1791	486	17	such	such	ADJ
bam-1791	486	18	as	as	ADP
bam-1791	486	19	myog	myog	NOUN
bam-1791	486	20	,	,	PUNCT
bam-1791	486	21	myod	myod	NOUN
bam-1791	486	22	,	,	PUNCT
bam-1791	486	23	myf5	myf5	NOUN
bam-1791	486	24	and	and	CCONJ
bam-1791	486	25	pax7	pax7	PROPN
bam-1791	486	26	.	.	PUNCT
bam-1791	487	1	for	for	ADP
bam-1791	487	2	comparison	comparison	NOUN
bam-1791	487	3	,	,	PUNCT
bam-1791	487	4	the	the	DET
bam-1791	487	5	same	same	ADJ
bam-1791	487	6	factors	factor	NOUN
bam-1791	487	7	were	be	AUX
bam-1791	487	8	analyzed	analyze	VERB
bam-1791	487	9	in	in	ADP
bam-1791	487	10	obese	obese	ADJ
bam-1791	487	11	subjects	subject	NOUN
bam-1791	487	12	,	,	PUNCT
bam-1791	487	13	reported	report	VERB
bam-1791	487	14	to	to	PART
bam-1791	487	15	be	be	AUX
bam-1791	487	16	sarcopenic	sarcopenic	ADJ
bam-1791	487	17	,	,	PUNCT
bam-1791	487	18	and	and	CCONJ
bam-1791	487	19	in	in	ADP
bam-1791	487	20	breast	breast	NOUN
bam-1791	487	21	cancer	cancer	NOUN
bam-1791	487	22	patients	patient	NOUN
bam-1791	487	23	,	,	PUNCT
bam-1791	487	24	rarely	rarely	ADV
bam-1791	487	25	showing	show	VERB
bam-1791	487	26	muscle	muscle	NOUN
bam-1791	487	27	atrophy	atrophy	NOUN
bam-1791	487	28	.	.	PUNCT
bam-1791	488	1	three	three	NUM
bam-1791	488	2	muscle	muscle	NOUN
bam-1791	488	3	biopsies	biopsy	NOUN
bam-1791	488	4	(	(	PUNCT
bam-1791	488	5	vastus	vastus	NOUN
bam-1791	488	6	lateralis	laterali	NOUN
bam-1791	488	7	)	)	PUNCT
bam-1791	488	8	were	be	AUX
bam-1791	488	9	obtained	obtain	VERB
bam-1791	488	10	at	at	ADP
bam-1791	488	11	different	different	ADJ
bam-1791	488	12	time	time	NOUN
bam-1791	488	13	points	point	NOUN
bam-1791	488	14	by	by	ADP
bam-1791	488	15	volunteers	volunteer	NOUN
bam-1791	488	16	recruited	recruit	VERB
bam-1791	488	17	for	for	ADP
bam-1791	488	18	a	a	DET
bam-1791	488	19	period	period	NOUN
bam-1791	488	20	of	of	ADP
bam-1791	488	21	bed	bed	NOUN
bam-1791	488	22	-	-	PUNCT
bam-1791	488	23	rest	rest	NOUN
bam-1791	488	24	(	(	PUNCT
bam-1791	488	25	day	day	NOUN
bam-1791	488	26	-1	-1	ADP
bam-1791	488	27	,	,	PUNCT
bam-1791	488	28	7	7	NUM
bam-1791	488	29	and	and	CCONJ
bam-1791	488	30	33	33	NUM
bam-1791	488	31	of	of	ADP
bam-1791	488	32	bed	bed	NOUN
bam-1791	488	33	-	-	PUNCT
bam-1791	488	34	rest	rest	NOUN
bam-1791	488	35	)	)	PUNCT
bam-1791	488	36	.	.	PUNCT
bam-1791	489	1	abdominal	abdominal	ADJ
bam-1791	489	2	muscle	muscle	NOUN
bam-1791	489	3	biopsies	biopsy	NOUN
bam-1791	489	4	were	be	AUX
bam-1791	489	5	taken	take	VERB
bam-1791	489	6	during	during	ADP
bam-1791	489	7	surgery	surgery	NOUN
bam-1791	489	8	in	in	ADP
bam-1791	489	9	patients	patient	NOUN
bam-1791	489	10	affected	affect	VERB
bam-1791	489	11	by	by	ADP
bam-1791	489	12	:	:	PUNCT
bam-1791	489	13	benign	benign	ADJ
bam-1791	489	14	disease	disease	NOUN
bam-1791	489	15	(	(	PUNCT
bam-1791	489	16	controls	control	NOUN
bam-1791	489	17	)	)	PUNCT
bam-1791	489	18	,	,	PUNCT
bam-1791	489	19	breast	breast	NOUN
bam-1791	489	20	cancer	cancer	NOUN
bam-1791	489	21	,	,	PUNCT
bam-1791	489	22	obesity	obesity	NOUN
bam-1791	489	23	.	.	PUNCT
bam-1791	490	1	gene	gene	NOUN
bam-1791	490	2	expression	expression	NOUN
bam-1791	490	3	of	of	ADP
bam-1791	490	4	myog	myog	NOUN
bam-1791	490	5	,	,	PUNCT
bam-1791	490	6	myod	myod	NOUN
bam-1791	490	7	,	,	PUNCT
bam-1791	490	8	myf5	myf5	PROPN
bam-1791	490	9	and	and	CCONJ
bam-1791	490	10	pax7	pax7	PROPN
bam-1791	490	11	was	be	AUX
bam-1791	490	12	assessed	assess	VERB
bam-1791	490	13	by	by	ADP
bam-1791	490	14	qrtpcr	qrtpcr	PROPN
bam-1791	490	15	.	.	PUNCT
bam-1791	491	1	pax7	pax7	PROPN
bam-1791	491	2	and	and	CCONJ
bam-1791	491	3	myf5	myf5	NOUN
bam-1791	491	4	expression	expression	NOUN
bam-1791	491	5	at	at	ADP
bam-1791	491	6	days	day	NOUN
bam-1791	491	7	7	7	NUM
bam-1791	491	8	and	and	CCONJ
bam-1791	491	9	33	33	NUM
bam-1791	491	10	of	of	ADP
bam-1791	491	11	bed	bed	NOUN
bam-1791	491	12	-	-	PUNCT
bam-1791	491	13	rest	rest	NOUN
bam-1791	491	14	tends	tend	VERB
bam-1791	491	15	to	to	PART
bam-1791	491	16	reduction	reduction	VERB
bam-1791	491	17	vs	vs	ADP
bam-1791	491	18	day	day	NOUN
bam-1791	491	19	-1	-1	INTJ
bam-1791	491	20	.	.	PUNCT
bam-1791	492	1	myod	myod	PROPN
bam-1791	492	2	levels	level	NOUN
bam-1791	492	3	decrease	decrease	NOUN
bam-1791	492	4	of	of	ADP
bam-1791	492	5	75	75	NUM
bam-1791	492	6	%	%	NOUN
bam-1791	492	7	and	and	CCONJ
bam-1791	492	8	50	50	NUM
bam-1791	492	9	%	%	NOUN
bam-1791	492	10	after	after	ADP
bam-1791	492	11	7	7	NUM
bam-1791	492	12	and	and	CCONJ
bam-1791	492	13	33	33	NUM
bam-1791	492	14	days	day	NOUN
bam-1791	492	15	,	,	PUNCT
bam-1791	492	16	respectively	respectively	ADV
bam-1791	492	17	,	,	PUNCT
bam-1791	492	18	and	and	CCONJ
bam-1791	492	19	myog	myog	NOUN
bam-1791	492	20	tends	tend	VERB
bam-1791	492	21	to	to	PART
bam-1791	492	22	increase	increase	VERB
bam-1791	492	23	.	.	PUNCT
bam-1791	493	1	in	in	ADP
bam-1791	493	2	breast	breast	NOUN
bam-1791	493	3	cancer	cancer	NOUN
bam-1791	493	4	patients	patient	NOUN
bam-1791	493	5	the	the	DET
bam-1791	493	6	expression	expression	NOUN
bam-1791	493	7	of	of	ADP
bam-1791	493	8	myod	myod	PROPN
bam-1791	493	9	,	,	PUNCT
bam-1791	493	10	pax7	pax7	NOUN
bam-1791	493	11	and	and	CCONJ
bam-1791	493	12	myf5	myf5	NOUN
bam-1791	493	13	decreases	decrease	VERB
bam-1791	493	14	significantly	significantly	ADV
bam-1791	493	15	of	of	ADP
bam-1791	493	16	about	about	ADV
bam-1791	493	17	40	40	NUM
bam-1791	493	18	%	%	NOUN
bam-1791	493	19	vs	vs	ADP
bam-1791	493	20	controls	control	NOUN
bam-1791	493	21	.	.	PUNCT
bam-1791	494	1	in	in	ADP
bam-1791	494	2	obese	obese	ADJ
bam-1791	494	3	patients	patient	NOUN
bam-1791	494	4	myod	myod	VERB
bam-1791	494	5	expression	expression	NOUN
bam-1791	494	6	decreases	decrease	NOUN
bam-1791	494	7	of	of	ADP
bam-1791	494	8	about	about	ADV
bam-1791	494	9	50	50	NUM
bam-1791	494	10	%	%	NOUN
bam-1791	494	11	vs	vs	ADP
bam-1791	494	12	controls	control	NOUN
bam-1791	494	13	,	,	PUNCT
bam-1791	494	14	myf5	myf5	NOUN
bam-1791	494	15	increases	increase	VERB
bam-1791	494	16	significantly	significantly	ADV
bam-1791	494	17	while	while	SCONJ
bam-1791	494	18	pax7	pax7	PROPN
bam-1791	494	19	tends	tend	VERB
bam-1791	494	20	to	to	PART
bam-1791	494	21	increase	increase	VERB
bam-1791	494	22	.	.	PUNCT
bam-1791	495	1	these	these	DET
bam-1791	495	2	results	result	NOUN
bam-1791	495	3	show	show	VERB
bam-1791	495	4	that	that	SCONJ
bam-1791	495	5	bed	bed	NOUN
bam-1791	495	6	-	-	PUNCT
bam-1791	495	7	rest	rest	NOUN
bam-1791	495	8	is	be	AUX
bam-1791	495	9	associated	associate	VERB
bam-1791	495	10	with	with	ADP
bam-1791	495	11	a	a	DET
bam-1791	495	12	tendency	tendency	NOUN
bam-1791	495	13	to	to	ADP
bam-1791	495	14	down	down	ADP
bam-1791	495	15	-	-	PUNCT
bam-1791	495	16	regulation	regulation	NOUN
bam-1791	495	17	of	of	ADP
bam-1791	495	18	pax7	pax7	NOUN
bam-1791	495	19	and	and	CCONJ
bam-1791	495	20	myf5	myf5	PROPN
bam-1791	495	21	mrna	mrna	PROPN
bam-1791	495	22	levels	level	NOUN
bam-1791	495	23	.	.	PUNCT
bam-1791	496	1	this	this	PRON
bam-1791	496	2	could	could	AUX
bam-1791	496	3	indicate	indicate	VERB
bam-1791	496	4	a	a	DET
bam-1791	496	5	reduced	reduce	VERB
bam-1791	496	6	satellite	satellite	NOUN
bam-1791	496	7	cell	cell	NOUN
bam-1791	496	8	population	population	NOUN
bam-1791	496	9	,	,	PUNCT
bam-1791	496	10	possibly	possibly	ADV
bam-1791	496	11	resulting	result	VERB
bam-1791	496	12	from	from	ADP
bam-1791	496	13	enhanced	enhanced	ADJ
bam-1791	496	14	differentiation	differentiation	NOUN
bam-1791	496	15	,	,	PUNCT
bam-1791	496	16	as	as	SCONJ
bam-1791	496	17	suggested	suggest	VERB
bam-1791	496	18	by	by	ADP
bam-1791	496	19	myog	myog	NOUN
bam-1791	496	20	levels	level	NOUN
bam-1791	496	21	.	.	PUNCT
bam-1791	497	1	by	by	ADP
bam-1791	497	2	contrast	contrast	NOUN
bam-1791	497	3	,	,	PUNCT
bam-1791	497	4	obesity	obesity	NOUN
bam-1791	497	5	appears	appear	VERB
bam-1791	497	6	associated	associate	VERB
bam-1791	497	7	with	with	ADP
bam-1791	497	8	maintenance	maintenance	NOUN
bam-1791	497	9	of	of	ADP
bam-1791	497	10	the	the	DET
bam-1791	497	11	satellite	satellite	NOUN
bam-1791	497	12	cell	cell	NOUN
bam-1791	497	13	population	population	NOUN
bam-1791	497	14	,	,	PUNCT
bam-1791	497	15	as	as	SCONJ
bam-1791	497	16	suggested	suggest	VERB
bam-1791	497	17	by	by	ADP
bam-1791	497	18	the	the	DET
bam-1791	497	19	increased	increase	VERB
bam-1791	497	20	levels	level	NOUN
bam-1791	497	21	of	of	ADP
bam-1791	497	22	both	both	CCONJ
bam-1791	497	23	myf5	myf5	NOUN
bam-1791	497	24	and	and	CCONJ
bam-1791	497	25	pax7	pax7	PROPN
bam-1791	497	26	.	.	PUNCT
bam-1791	498	1	finally	finally	ADV
bam-1791	498	2	,	,	PUNCT
bam-1791	498	3	the	the	DET
bam-1791	498	4	pattern	pattern	NOUN
bam-1791	498	5	observed	observe	VERB
bam-1791	498	6	in	in	ADP
bam-1791	498	7	breast	breast	NOUN
bam-1791	498	8	cancer	cancer	NOUN
bam-1791	498	9	patients	patient	NOUN
bam-1791	498	10	could	could	AUX
bam-1791	498	11	indicate	indicate	VERB
bam-1791	498	12	an	an	DET
bam-1791	498	13	impairment	impairment	NOUN
bam-1791	498	14	of	of	ADP
bam-1791	498	15	myogenesis	myogenesis	NOUN
bam-1791	498	16	.	.	PUNCT
bam-1791	499	1	42	42	NUM
bam-1791	499	2	.	.	PUNCT
bam-1791	500	1	autophagic	autophagic	PROPN
bam-1791	500	2	degradation	degradation	NOUN
bam-1791	500	3	contributes	contribute	VERB
bam-1791	500	4	to	to	ADP
bam-1791	500	5	muscle	muscle	NOUN
bam-1791	500	6	wasting	waste	VERB
bam-1791	500	7	in	in	ADP
bam-1791	500	8	cancer	cancer	NOUN
bam-1791	500	9	cachexia	cachexia	PROPN
bam-1791	500	10	f	f	PROPN
bam-1791	500	11	penna1	penna1	PROPN
bam-1791	500	12	,	,	PUNCT
bam-1791	500	13	d	d	PROPN
bam-1791	500	14	costamagna1	costamagna1	PROPN
bam-1791	500	15	,	,	PUNCT
bam-1791	500	16	f	f	PROPN
bam-1791	500	17	pin1	pin1	NOUN
bam-1791	500	18	,	,	PUNCT
bam-1791	500	19	a	a	DET
bam-1791	500	20	camperi1	camperi1	PROPN
bam-1791	500	21	,	,	PUNCT
bam-1791	500	22	a	a	DET
bam-1791	500	23	fanzani2	fanzani2	NOUN
bam-1791	500	24	,	,	PUNCT
bam-1791	500	25	g	g	PROPN
bam-1791	500	26	bonelli1	bonelli1	NOUN
bam-1791	500	27	,	,	PUNCT
bam-1791	500	28	p	p	NOUN
bam-1791	500	29	costelli1	costelli1	NOUN
bam-1791	500	30	1department	1department	NUM
bam-1791	500	31	of	of	ADP
bam-1791	500	32	experimental	experimental	ADJ
bam-1791	500	33	medicine	medicine	NOUN
bam-1791	500	34	and	and	CCONJ
bam-1791	500	35	oncology	oncology	NOUN
bam-1791	500	36	,	,	PUNCT
bam-1791	500	37	university	university	NOUN
bam-1791	500	38	of	of	ADP
bam-1791	500	39	torino	torino	PROPN
bam-1791	500	40	,	,	PUNCT
bam-1791	500	41	italy	italy	PROPN
bam-1791	500	42	2department	2department	NUM
bam-1791	500	43	of	of	ADP
bam-1791	500	44	biomedical	biomedical	ADJ
bam-1791	500	45	sciences	science	NOUN
bam-1791	500	46	and	and	CCONJ
bam-1791	500	47	biotechnology	biotechnology	NOUN
bam-1791	500	48	,	,	PUNCT
bam-1791	500	49	university	university	NOUN
bam-1791	500	50	of	of	ADP
bam-1791	500	51	brescia	brescia	PROPN
bam-1791	500	52	,	,	PUNCT
bam-1791	500	53	italy	italy	PROPN
bam-1791	500	54	muscle	muscle	NOUN
bam-1791	500	55	protein	protein	NOUN
bam-1791	500	56	wasting	waste	VERB
bam-1791	500	57	in	in	ADP
bam-1791	500	58	cancer	cancer	NOUN
bam-1791	500	59	cachexia	cachexia	NOUN
bam-1791	500	60	is	be	AUX
bam-1791	500	61	a	a	DET
bam-1791	500	62	critical	critical	ADJ
bam-1791	500	63	problem	problem	NOUN
bam-1791	500	64	.	.	PUNCT
bam-1791	501	1	the	the	DET
bam-1791	501	2	underlying	underlying	ADJ
bam-1791	501	3	mechanisms	mechanism	NOUN
bam-1791	501	4	are	be	AUX
bam-1791	501	5	still	still	ADV
bam-1791	501	6	unclear	unclear	ADJ
bam-1791	501	7	,	,	PUNCT
bam-1791	501	8	although	although	SCONJ
bam-1791	501	9	the	the	DET
bam-1791	501	10	ubiquitin	ubiquitin	ADJ
bam-1791	501	11	-	-	PUNCT
bam-1791	501	12	proteasome	proteasome	NOUN
bam-1791	501	13	system	system	NOUN
bam-1791	501	14	has	have	AUX
bam-1791	501	15	been	be	AUX
bam-1791	501	16	involved	involve	VERB
bam-1791	501	17	in	in	ADP
bam-1791	501	18	the	the	DET
bam-1791	501	19	degradation	degradation	NOUN
bam-1791	501	20	of	of	ADP
bam-1791	501	21	bulk	bulk	ADJ
bam-1791	501	22	myofibrillar	myofibrillar	ADJ
bam-1791	501	23	proteins	protein	NOUN
bam-1791	501	24	.	.	PUNCT
bam-1791	502	1	the	the	DET
bam-1791	502	2	present	present	ADJ
bam-1791	502	3	work	work	NOUN
bam-1791	502	4	has	have	AUX
bam-1791	502	5	been	be	AUX
bam-1791	502	6	aimed	aim	VERB
bam-1791	502	7	to	to	PART
bam-1791	502	8	investigate	investigate	VERB
bam-1791	502	9	if	if	SCONJ
bam-1791	502	10	also	also	ADV
bam-1791	502	11	autophagic	autophagic	ADJ
bam-1791	502	12	degradation	degradation	NOUN
bam-1791	502	13	plays	play	VERB
bam-1791	502	14	a	a	DET
bam-1791	502	15	role	role	NOUN
bam-1791	502	16	in	in	ADP
bam-1791	502	17	the	the	DET
bam-1791	502	18	onset	onset	NOUN
bam-1791	502	19	of	of	ADP
bam-1791	502	20	muscle	muscle	NOUN
bam-1791	502	21	depletion	depletion	NOUN
bam-1791	502	22	in	in	ADP
bam-1791	502	23	cancerbearing	cancerbeare	VERB
bam-1791	502	24	animals	animal	NOUN
bam-1791	502	25	as	as	ADV
bam-1791	502	26	well	well	ADV
bam-1791	502	27	as	as	ADP
bam-1791	502	28	in	in	ADP
bam-1791	502	29	glucocorticoid	glucocorticoid	NOUN
bam-1791	502	30	-	-	PUNCT
bam-1791	502	31	induced	induced	ADJ
bam-1791	502	32	atrophy	atrophy	NOUN
bam-1791	502	33	.	.	PUNCT
bam-1791	503	1	the	the	DET
bam-1791	503	2	results	result	NOUN
bam-1791	503	3	show	show	VERB
bam-1791	503	4	that	that	SCONJ
bam-1791	503	5	autophagy	autophagy	NOUN
bam-1791	503	6	is	be	AUX
bam-1791	503	7	induced	induce	VERB
bam-1791	503	8	in	in	ADP
bam-1791	503	9	muscle	muscle	NOUN
bam-1791	503	10	in	in	ADP
bam-1791	503	11	three	three	NUM
bam-1791	503	12	different	different	ADJ
bam-1791	503	13	models	model	NOUN
bam-1791	503	14	of	of	ADP
bam-1791	503	15	cancer	cancer	NOUN
bam-1791	503	16	cachexia	cachexia	NOUN
bam-1791	503	17	as	as	ADV
bam-1791	503	18	well	well	ADV
bam-1791	503	19	as	as	ADP
bam-1791	503	20	in	in	ADP
bam-1791	503	21	glucocorticoid	glucocorticoid	NOUN
bam-1791	503	22	-	-	PUNCT
bam-1791	503	23	treated	treat	VERB
bam-1791	503	24	mice	mouse	NOUN
bam-1791	503	25	.	.	PUNCT
bam-1791	504	1	these	these	DET
bam-1791	504	2	results	result	NOUN
bam-1791	504	3	demonstrate	demonstrate	VERB
bam-1791	504	4	that	that	SCONJ
bam-1791	504	5	autophagy	autophagy	NOUN
bam-1791	504	6	contributes	contribute	VERB
bam-1791	504	7	to	to	ADP
bam-1791	504	8	the	the	DET
bam-1791	504	9	complicated	complicated	ADJ
bam-1791	504	10	network	network	NOUN
bam-1791	504	11	that	that	PRON
bam-1791	504	12	leads	lead	VERB
bam-1791	504	13	to	to	ADP
bam-1791	504	14	muscle	muscle	NOUN
bam-1791	504	15	atrophy	atrophy	NOUN
bam-1791	504	16	.	.	PUNCT
bam-1791	505	1	in	in	ADP
bam-1791	505	2	this	this	DET
bam-1791	505	3	regard	regard	NOUN
bam-1791	505	4	,	,	PUNCT
bam-1791	505	5	particularly	particularly	ADV
bam-1791	505	6	intriguing	intriguing	ADJ
bam-1791	505	7	is	be	AUX
bam-1791	505	8	the	the	DET
bam-1791	505	9	observation	observation	NOUN
bam-1791	505	10	that	that	SCONJ
bam-1791	505	11	in	in	ADP
bam-1791	505	12	both	both	DET
bam-1791	505	13	cancer	cancer	NOUN
bam-1791	505	14	hosts	host	NOUN
bam-1791	505	15	and	and	CCONJ
bam-1791	505	16	tnfalpha	tnfalpha	NOUN
bam-1791	505	17	-	-	PUNCT
bam-1791	505	18	treated	treat	VERB
bam-1791	505	19	c2c12	c2c12	PROPN
bam-1791	505	20	myotubes	myotube	NOUN
bam-1791	505	21	insulin	insulin	NOUN
bam-1791	505	22	can	can	AUX
bam-1791	505	23	only	only	ADV
bam-1791	505	24	partially	partially	ADV
bam-1791	505	25	blunt	blunt	VERB
bam-1791	505	26	autophagy	autophagy	ADJ
bam-1791	505	27	induction	induction	NOUN
bam-1791	505	28	.	.	PUNCT
bam-1791	506	1	this	this	PRON
bam-1791	506	2	would	would	AUX
bam-1791	506	3	suggest	suggest	VERB
bam-1791	506	4	that	that	SCONJ
bam-1791	506	5	autophagy	autophagy	NOUN
bam-1791	506	6	is	be	AUX
bam-1791	506	7	triggered	trigger	VERB
bam-1791	506	8	through	through	ADP
bam-1791	506	9	mechanisms	mechanism	NOUN
bam-1791	506	10	that	that	PRON
bam-1791	506	11	can	can	AUX
bam-1791	506	12	not	not	PART
bam-1791	506	13	be	be	AUX
bam-1791	506	14	circumvented	circumvent	VERB
bam-1791	506	15	by	by	ADP
bam-1791	506	16	using	use	VERB
bam-1791	506	17	classical	classical	ADJ
bam-1791	506	18	up	up	ADJ
bam-1791	506	19	-	-	PUNCT
bam-1791	506	20	stream	stream	NOUN
bam-1791	506	21	modulators	modulator	NOUN
bam-1791	506	22	,	,	PUNCT
bam-1791	506	23	prompting	prompt	VERB
bam-1791	506	24	to	to	PART
bam-1791	506	25	identify	identify	VERB
bam-1791	506	26	more	more	ADV
bam-1791	506	27	effective	effective	ADJ
bam-1791	506	28	approaches	approach	NOUN
bam-1791	506	29	to	to	PART
bam-1791	506	30	target	target	VERB
bam-1791	506	31	this	this	DET
bam-1791	506	32	proteolytic	proteolytic	ADJ
bam-1791	506	33	system	system	NOUN
bam-1791	506	34	.	.	PUNCT
bam-1791	507	1	43	43	NUM
bam-1791	507	2	.	.	PUNCT
bam-1791	507	3	mechanisms	mechanism	NOUN
bam-1791	507	4	underlying	underlie	VERB
bam-1791	507	5	exercise	exercise	NOUN
bam-1791	507	6	-	-	PUNCT
bam-1791	507	7	mediated	mediate	VERB
bam-1791	507	8	rescue	rescue	NOUN
bam-1791	507	9	of	of	ADP
bam-1791	507	10	cachexia	cachexia	PROPN
bam-1791	507	11	pigna	pigna	PROPN
bam-1791	507	12	e.a	e.a	PROPN
bam-1791	507	13	,	,	PUNCT
bam-1791	507	14	moresi	moresi	PROPN
bam-1791	507	15	va	va	PROPN
bam-1791	507	16	.	.	PROPN
bam-1791	507	17	,	,	PUNCT
bam-1791	507	18	aulino	aulino	PROPN
bam-1791	507	19	p.a	p.a	PROPN
bam-1791	507	20	,	,	PUNCT
bam-1791	507	21	berardi	berardi	PROPN
bam-1791	507	22	ea	ea	PROPN
bam-1791	507	23	.	.	PROPN
bam-1791	507	24	,	,	PUNCT
bam-1791	507	25	rossi	rossi	PROPN
bam-1791	507	26	e.a	e.a	PROPN
bam-1791	507	27	,	,	PUNCT
bam-1791	507	28	,	,	PUNCT
bam-1791	507	29	adamo	adamo	PROPN
bam-1791	507	30	s.	s.	PROPN
bam-1791	507	31	a	a	X
bam-1791	507	32	,	,	PUNCT
bam-1791	507	33	and	and	CCONJ
bam-1791	507	34	coletti	coletti	VERB
bam-1791	507	35	d.	d.	PROPN
bam-1791	507	36	a	a	PROPN
bam-1791	507	37	,	,	PUNCT
bam-1791	507	38	b	b	PROPN
bam-1791	507	39	a	a	DET
bam-1791	507	40	dept	dept	NOUN
bam-1791	507	41	.	.	PROPN
bam-1791	507	42	of	of	ADP
bam-1791	507	43	anat	anat	PROPN
bam-1791	507	44	.	.	PROPN
bam-1791	507	45	,	,	PUNCT
bam-1791	507	46	histol	histol	NOUN
bam-1791	507	47	.	.	PUNCT
bam-1791	507	48	,	,	PUNCT
bam-1791	507	49	forens	forens	PROPN
bam-1791	507	50	.	.	PROPN
bam-1791	507	51	&	&	CCONJ
bam-1791	507	52	orthop	orthop	PROPN
bam-1791	507	53	.	.	PUNCT
bam-1791	508	1	sciences	science	NOUN
bam-1791	508	2	,	,	PUNCT
bam-1791	508	3	sapienza	sapienza	PROPN
bam-1791	508	4	university	university	PROPN
bam-1791	508	5	of	of	ADP
bam-1791	508	6	rome	rome	PROPN
bam-1791	508	7	,	,	PUNCT
bam-1791	508	8	italy	italy	PROPN
bam-1791	508	9	;	;	PUNCT
bam-1791	508	10	b	b	X
bam-1791	508	11	ur4	ur4	PROPN
bam-1791	508	12	ageing	ageing	NOUN
bam-1791	508	13	,	,	PUNCT
bam-1791	508	14	stress	stress	NOUN
bam-1791	508	15	and	and	CCONJ
bam-1791	508	16	inflammation	inflammation	NOUN
bam-1791	508	17	,	,	PUNCT
bam-1791	508	18	pierre	pierre	PROPN
bam-1791	508	19	et	et	PROPN
bam-1791	508	20	marie	marie	PROPN
bam-1791	508	21	curie	curie	PROPN
bam-1791	508	22	university	university	PROPN
bam-1791	508	23	paris	paris	PROPN
bam-1791	508	24	6	6	NUM
bam-1791	508	25	,	,	PUNCT
bam-1791	508	26	france	france	PROPN
bam-1791	508	27	cachexia	cachexia	PROPN
bam-1791	508	28	is	be	AUX
bam-1791	508	29	a	a	DET
bam-1791	508	30	syndrome	syndrome	NOUN
bam-1791	508	31	associated	associate	VERB
bam-1791	508	32	with	with	ADP
bam-1791	508	33	many	many	ADJ
bam-1791	508	34	diseases	disease	NOUN
bam-1791	508	35	,	,	PUNCT
bam-1791	508	36	characterized	characterize	VERB
bam-1791	508	37	by	by	ADP
bam-1791	508	38	severe	severe	ADJ
bam-1791	508	39	muscle	muscle	NOUN
bam-1791	508	40	atrophy	atrophy	NOUN
bam-1791	508	41	and	and	CCONJ
bam-1791	508	42	weakness	weakness	NOUN
bam-1791	508	43	,	,	PUNCT
bam-1791	508	44	accounting	account	VERB
bam-1791	508	45	for	for	ADP
bam-1791	508	46	poor	poor	ADJ
bam-1791	508	47	prognosis	prognosis	NOUN
bam-1791	508	48	and	and	CCONJ
bam-1791	508	49	worsening	worsen	VERB
bam-1791	508	50	patients	patient	NOUN
bam-1791	508	51	quality	quality	NOUN
bam-1791	508	52	of	of	ADP
bam-1791	508	53	life	life	NOUN
bam-1791	508	54	.	.	PUNCT
bam-1791	509	1	recent	recent	ADJ
bam-1791	509	2	studies	study	NOUN
bam-1791	509	3	showed	show	VERB
bam-1791	509	4	that	that	SCONJ
bam-1791	509	5	physical	physical	ADJ
bam-1791	509	6	activity	activity	NOUN
bam-1791	509	7	after	after	SCONJ
bam-1791	509	8	cancer	cancer	NOUN
bam-1791	509	9	diagnosis	diagnosis	NOUN
bam-1791	509	10	ameliorates	ameliorate	VERB
bam-1791	509	11	the	the	DET
bam-1791	509	12	prognosis	prognosis	NOUN
bam-1791	509	13	,	,	PUNCT
bam-1791	509	14	although	although	SCONJ
bam-1791	509	15	the	the	DET
bam-1791	509	16	underling	underling	NOUN
bam-1791	509	17	mechanisms	mechanism	NOUN
bam-1791	509	18	are	be	AUX
bam-1791	509	19	still	still	ADV
bam-1791	509	20	poorly	poorly	ADV
bam-1791	509	21	understood	understand	VERB
bam-1791	509	22	.	.	PUNCT
bam-1791	510	1	with	with	ADP
bam-1791	510	2	the	the	DET
bam-1791	510	3	aim	aim	NOUN
bam-1791	510	4	to	to	PART
bam-1791	510	5	characterize	characterize	VERB
bam-1791	510	6	the	the	DET
bam-1791	510	7	pathways	pathway	NOUN
bam-1791	510	8	involved	involve	VERB
bam-1791	510	9	in	in	ADP
bam-1791	510	10	exercise	exercise	NOUN
bam-1791	510	11	-	-	PUNCT
bam-1791	510	12	mediated	mediate	VERB
bam-1791	510	13	rescue	rescue	NOUN
bam-1791	510	14	of	of	ADP
bam-1791	510	15	cachexia	cachexia	NOUN
bam-1791	510	16	,	,	PUNCT
bam-1791	510	17	we	we	PRON
bam-1791	510	18	investigate	investigate	VERB
bam-1791	510	19	the	the	DET
bam-1791	510	20	effects	effect	NOUN
bam-1791	510	21	of	of	ADP
bam-1791	510	22	spontaneous	spontaneous	ADJ
bam-1791	510	23	physical	physical	ADJ
bam-1791	510	24	activity	activity	NOUN
bam-1791	510	25	(	(	PUNCT
bam-1791	510	26	wheel	wheel	NOUN
bam-1791	510	27	running	run	VERB
bam-1791	510	28	)	)	PUNCT
bam-1791	510	29	in	in	ADP
bam-1791	510	30	colon	colon	NOUN
bam-1791	510	31	carcinoma	carcinoma	NOUN
bam-1791	510	32	(	(	PUNCT
bam-1791	510	33	c26)-bearing	c26)-beare	VERB
bam-1791	510	34	mice	mouse	NOUN
bam-1791	510	35	.	.	PUNCT
bam-1791	511	1	all	all	DET
bam-1791	511	2	major	major	ADJ
bam-1791	511	3	diagnostic	diagnostic	ADJ
bam-1791	511	4	criteria	criterion	NOUN
bam-1791	511	5	for	for	ADP
bam-1791	511	6	cachexia	cachexia	NOUN
bam-1791	511	7	are	be	AUX
bam-1791	511	8	reversed	reverse	VERB
bam-1791	511	9	by	by	ADP
bam-1791	511	10	exercise	exercise	NOUN
bam-1791	511	11	,	,	PUNCT
bam-1791	511	12	including	include	VERB
bam-1791	511	13	rescue	rescue	NOUN
bam-1791	511	14	of	of	ADP
bam-1791	511	15	body	body	NOUN
bam-1791	511	16	weight	weight	NOUN
bam-1791	511	17	,	,	PUNCT
bam-1791	511	18	muscle	muscle	NOUN
bam-1791	511	19	atrophy	atrophy	NOUN
bam-1791	511	20	and	and	CCONJ
bam-1791	511	21	fatigue	fatigue	NOUN
bam-1791	511	22	,	,	PUNCT
bam-1791	511	23	ultimately	ultimately	ADV
bam-1791	511	24	leading	lead	VERB
bam-1791	511	25	to	to	ADP
bam-1791	511	26	increased	increase	VERB
bam-1791	511	27	survival	survival	NOUN
bam-1791	511	28	.	.	PUNCT
bam-1791	512	1	these	these	DET
bam-1791	512	2	data	datum	NOUN
bam-1791	512	3	suggest	suggest	VERB
bam-1791	512	4	a	a	DET
bam-1791	512	5	potential	potential	ADJ
bam-1791	512	6	role	role	NOUN
bam-1791	512	7	for	for	ADP
bam-1791	512	8	the	the	DET
bam-1791	512	9	use	use	NOUN
bam-1791	512	10	of	of	ADP
bam-1791	512	11	exercise	exercise	NOUN
bam-1791	512	12	mimetics	mimetic	NOUN
bam-1791	512	13	to	to	PART
bam-1791	512	14	counteract	counteract	VERB
bam-1791	512	15	cachexia	cachexia	NOUN
bam-1791	512	16	.	.	PUNCT
bam-1791	513	1	indeed	indeed	ADV
bam-1791	513	2	,	,	PUNCT
bam-1791	513	3	c26	c26	NOUN
bam-1791	513	4	-	-	PUNCT
bam-1791	513	5	bearing	bear	VERB
bam-1791	513	6	mice	mouse	NOUN
bam-1791	513	7	treated	treat	VERB
bam-1791	513	8	with	with	ADP
bam-1791	513	9	aicar	aicar	NOUN
bam-1791	513	10	,	,	PUNCT
bam-1791	513	11	a	a	DET
bam-1791	513	12	well	well	ADV
bam-1791	513	13	-	-	PUNCT
bam-1791	513	14	known	know	VERB
bam-1791	513	15	exercise	exercise	NOUN
bam-1791	513	16	-	-	PUNCT
bam-1791	513	17	mimetic	mimetic	ADJ
bam-1791	513	18	,	,	PUNCT
bam-1791	513	19	significantly	significantly	ADV
bam-1791	513	20	lost	lose	VERB
bam-1791	513	21	less	less	ADJ
bam-1791	513	22	body	body	NOUN
bam-1791	513	23	and	and	CCONJ
bam-1791	513	24	muscle	muscle	NOUN
bam-1791	513	25	weight	weight	NOUN
bam-1791	513	26	than	than	ADP
bam-1791	513	27	c26	c26	NOUN
bam-1791	513	28	-	-	PUNCT
bam-1791	513	29	bearing	bear	VERB
bam-1791	513	30	vehicle	vehicle	NOUN
bam-1791	513	31	-	-	PUNCT
bam-1791	513	32	treated	treat	VERB
bam-1791	513	33	mice	mouse	NOUN
bam-1791	513	34	.	.	PUNCT
bam-1791	514	1	in	in	ADP
bam-1791	514	2	order	order	NOUN
bam-1791	514	3	to	to	PART
bam-1791	514	4	assess	assess	VERB
bam-1791	514	5	whether	whether	SCONJ
bam-1791	514	6	muscle	muscle	NOUN
bam-1791	514	7	contraction	contraction	NOUN
bam-1791	514	8	plays	play	VERB
bam-1791	514	9	a	a	DET
bam-1791	514	10	role	role	NOUN
bam-1791	514	11	in	in	ADP
bam-1791	514	12	the	the	DET
bam-1791	514	13	exercisemediated	exercisemediate	VERB
bam-1791	514	14	rescue	rescue	NOUN
bam-1791	514	15	of	of	ADP
bam-1791	514	16	cachexia	cachexia	NOUN
bam-1791	514	17	,	,	PUNCT
bam-1791	514	18	we	we	PRON
bam-1791	514	19	denervated	denervate	VERB
bam-1791	514	20	one	one	NUM
bam-1791	514	21	limb	limb	NOUN
bam-1791	514	22	of	of	ADP
bam-1791	514	23	(	(	PUNCT
bam-1791	514	24	c26)-bearing	c26)-beare	VERB
bam-1791	514	25	mice	mouse	NOUN
bam-1791	514	26	and	and	CCONJ
bam-1791	514	27	assessed	assess	VERB
bam-1791	514	28	muscle	muscle	NOUN
bam-1791	514	29	mass	mass	NOUN
bam-1791	514	30	following	follow	VERB
bam-1791	514	31	spontaneous	spontaneous	ADJ
bam-1791	514	32	running	running	NOUN
bam-1791	514	33	.	.	PUNCT
bam-1791	515	1	interestingly	interestingly	ADV
bam-1791	515	2	,	,	PUNCT
bam-1791	515	3	exercise	exercise	NOUN
bam-1791	515	4	exerts	exert	VERB
bam-1791	515	5	positive	positive	ADJ
bam-1791	515	6	effects	effect	NOUN
bam-1791	515	7	on	on	ADP
bam-1791	515	8	(	(	PUNCT
bam-1791	515	9	c26)-bearing	c26)-beare	VERB
bam-1791	515	10	mice	mice	NOUN
bam-1791	515	11	muscle	muscle	NOUN
bam-1791	515	12	mass	mass	PROPN
bam-1791	515	13	independently	independently	ADV
bam-1791	515	14	from	from	ADP
bam-1791	515	15	denervation	denervation	NOUN
bam-1791	515	16	,	,	PUNCT
bam-1791	515	17	suggesting	suggest	VERB
bam-1791	515	18	cross	cross	NOUN
bam-1791	515	19	-	-	ADJ
bam-1791	515	20	education	education	NOUN
bam-1791	515	21	induced	induce	VERB
bam-1791	515	22	by	by	ADP
bam-1791	515	23	exercise	exercise	NOUN
bam-1791	515	24	on	on	ADP
bam-1791	515	25	the	the	DET
bam-1791	515	26	denervated	denervated	ADJ
bam-1791	515	27	muscle	muscle	NOUN
bam-1791	515	28	.	.	PUNCT
bam-1791	516	1	our	our	PRON
bam-1791	516	2	data	datum	NOUN
bam-1791	516	3	suggest	suggest	VERB
bam-1791	516	4	that	that	SCONJ
bam-1791	516	5	exercise	exercise	NOUN
bam-1791	516	6	counteracts	counteract	VERB
bam-1791	516	7	muscle	muscle	NOUN
bam-1791	516	8	wasting	waste	VERB
bam-1791	516	9	through	through	ADP
bam-1791	516	10	a	a	DET
bam-1791	516	11	systemic	systemic	ADJ
bam-1791	516	12	effect	effect	NOUN
bam-1791	516	13	and	and	CCONJ
bam-1791	516	14	that	that	PRON
bam-1791	516	15	exercise	exercise	NOUN
bam-1791	516	16	mimetics	mimetic	NOUN
bam-1791	516	17	can	can	AUX
bam-1791	516	18	be	be	AUX
bam-1791	516	19	used	use	VERB
bam-1791	516	20	to	to	PART
bam-1791	516	21	ameliorate	ameliorate	VERB
bam-1791	516	22	cachexia	cachexia	NOUN
bam-1791	516	23	.	.	PUNCT