id sid tid token lemma pos bam-1807 1 1 microsoft microsoft PROPN bam-1807 1 2 word word NOUN bam-1807 1 3 10ejtmmyorev1_3 10ejtmmyorev1_3 NUM bam-1807 1 4 _ _ NOUN bam-1807 1 5 105 105 NUM bam-1807 1 6 - - SYM bam-1807 1 7 120 120 NUM bam-1807 1 8 marini marini NOUN bam-1807 1 9 e e NOUN bam-1807 1 10 - - NOUN bam-1807 1 11 pub pub NOUN bam-1807 1 12 apr08.doc apr08.doc NOUN bam-1807 1 13 the the DET bam-1807 1 14 exercised exercise VERB bam-1807 1 15 skeletal skeletal ADJ bam-1807 1 16 muscle muscle NOUN bam-1807 1 17 european european PROPN bam-1807 1 18 journal journal PROPN bam-1807 1 19 translational translational ADJ bam-1807 1 20 myology myology NOUN bam-1807 1 21 myology myology NOUN bam-1807 1 22 reviews review NOUN bam-1807 1 23 2010 2010 NUM bam-1807 1 24 ; ; PUNCT bam-1807 1 25 20 20 NUM bam-1807 1 26 ( ( PUNCT bam-1807 1 27 3 3 NUM bam-1807 1 28 ): ): PUNCT bam-1807 1 29 105 105 NUM bam-1807 1 30 - - SYM bam-1807 1 31 120 120 NUM bam-1807 1 32 105 105 NUM bam-1807 1 33 the the DET bam-1807 1 34 exercised exercise VERB bam-1807 1 35 skeletal skeletal ADJ bam-1807 1 36 muscle muscle NOUN bam-1807 1 37 : : PUNCT bam-1807 1 38 a a DET bam-1807 1 39 review review NOUN bam-1807 1 40 marina marina NOUN bam-1807 1 41 marini marini X bam-1807 1 42 ( ( PUNCT bam-1807 1 43 1,2 1,2 NUM bam-1807 1 44 ) ) PUNCT bam-1807 1 45 , , PUNCT bam-1807 1 46 arsenio arsenio PROPN bam-1807 1 47 veicsteinas veicsteinas PROPN bam-1807 1 48 ( ( PUNCT bam-1807 1 49 3,4 3,4 NUM bam-1807 1 50 ) ) PUNCT bam-1807 1 51 ( ( PUNCT bam-1807 1 52 1 1 X bam-1807 1 53 ) ) PUNCT bam-1807 1 54 department department NOUN bam-1807 1 55 of of ADP bam-1807 1 56 histology histology PROPN bam-1807 1 57 , , PUNCT bam-1807 1 58 embryology embryology NOUN bam-1807 1 59 , , PUNCT bam-1807 1 60 and and CCONJ bam-1807 1 61 applied apply VERB bam-1807 1 62 biology biology NOUN bam-1807 1 63 , , PUNCT bam-1807 1 64 university university NOUN bam-1807 1 65 of of ADP bam-1807 1 66 bologna bologna PROPN bam-1807 1 67 , , PUNCT bam-1807 1 68 italy italy PROPN bam-1807 1 69 ; ; PUNCT bam-1807 1 70 ( ( PUNCT bam-1807 1 71 2 2 X bam-1807 1 72 ) ) PUNCT bam-1807 1 73 iim iim NOUN bam-1807 1 74 , , PUNCT bam-1807 1 75 interuniversitary interuniversitary PROPN bam-1807 1 76 institute institute PROPN bam-1807 1 77 of of ADP bam-1807 1 78 myology myology PROPN bam-1807 1 79 , , PUNCT bam-1807 1 80 italy italy PROPN bam-1807 1 81 ; ; PUNCT bam-1807 1 82 ( ( PUNCT bam-1807 1 83 3 3 X bam-1807 1 84 ) ) PUNCT bam-1807 1 85 department department NOUN bam-1807 1 86 of of ADP bam-1807 1 87 sport sport PROPN bam-1807 1 88 sciences sciences PROPN bam-1807 1 89 , , PUNCT bam-1807 1 90 nutrition nutrition NOUN bam-1807 1 91 and and CCONJ bam-1807 1 92 health health NOUN bam-1807 1 93 , , PUNCT bam-1807 1 94 university university PROPN bam-1807 1 95 of of ADP bam-1807 1 96 milan milan PROPN bam-1807 1 97 , , PUNCT bam-1807 1 98 italy italy PROPN bam-1807 1 99 ; ; PUNCT bam-1807 1 100 ( ( PUNCT bam-1807 1 101 4 4 X bam-1807 1 102 ) ) PUNCT bam-1807 1 103 center center NOUN bam-1807 1 104 of of ADP bam-1807 1 105 sport sport NOUN bam-1807 1 106 medicine medicine NOUN bam-1807 1 107 , , PUNCT bam-1807 1 108 don don PROPN bam-1807 1 109 gnocchi gnocchi PROPN bam-1807 1 110 foundation foundation PROPN bam-1807 1 111 , , PUNCT bam-1807 1 112 milan milan PROPN bam-1807 1 113 , , PUNCT bam-1807 1 114 italy italy PROPN bam-1807 1 115 abstract abstract ADJ bam-1807 1 116 the the DET bam-1807 1 117 skeletal skeletal ADJ bam-1807 1 118 muscle muscle NOUN bam-1807 1 119 is be AUX bam-1807 1 120 the the DET bam-1807 1 121 second second ADJ bam-1807 1 122 more more ADJ bam-1807 1 123 plastic plastic ADJ bam-1807 1 124 tissue tissue NOUN bam-1807 1 125 of of ADP bam-1807 1 126 the the DET bam-1807 1 127 body body NOUN bam-1807 1 128 second second ADJ bam-1807 1 129 to to ADP bam-1807 1 130 the the DET bam-1807 1 131 nervous nervous ADJ bam-1807 1 132 tissue tissue NOUN bam-1807 1 133 only only ADV bam-1807 1 134 . . PUNCT bam-1807 2 1 in in ADP bam-1807 2 2 fact fact NOUN bam-1807 2 3 , , PUNCT bam-1807 2 4 both both PRON bam-1807 2 5 physical physical ADJ bam-1807 2 6 activity activity NOUN bam-1807 2 7 and and CCONJ bam-1807 2 8 inactivity inactivity NOUN bam-1807 2 9 contribute contribute VERB bam-1807 2 10 to to PART bam-1807 2 11 modify modify VERB bam-1807 2 12 the the DET bam-1807 2 13 skeletal skeletal ADJ bam-1807 2 14 muscle muscle NOUN bam-1807 2 15 , , PUNCT bam-1807 2 16 by by ADP bam-1807 2 17 continuous continuous ADJ bam-1807 2 18 signaling signal VERB bam-1807 2 19 through through ADP bam-1807 2 20 nerve nerve NOUN bam-1807 2 21 impulses impulse NOUN bam-1807 2 22 , , PUNCT bam-1807 2 23 mechanical mechanical ADJ bam-1807 2 24 stimuli stimulus NOUN bam-1807 2 25 and and CCONJ bam-1807 2 26 humoral humoral ADJ bam-1807 2 27 clues clue NOUN bam-1807 2 28 . . PUNCT bam-1807 3 1 in in ADP bam-1807 3 2 turn turn NOUN bam-1807 3 3 , , PUNCT bam-1807 3 4 the the DET bam-1807 3 5 skeletal skeletal ADJ bam-1807 3 6 muscle muscle NOUN bam-1807 3 7 sends send VERB bam-1807 3 8 signals signal NOUN bam-1807 3 9 to to ADP bam-1807 3 10 the the DET bam-1807 3 11 body body NOUN bam-1807 3 12 , , PUNCT bam-1807 3 13 thus thus ADV bam-1807 3 14 contributing contribute VERB bam-1807 3 15 to to ADP bam-1807 3 16 its its PRON bam-1807 3 17 homeostasis homeostasis NOUN bam-1807 3 18 . . PUNCT bam-1807 4 1 we we PRON bam-1807 4 2 'll will AUX bam-1807 4 3 review review VERB bam-1807 4 4 here here ADV bam-1807 4 5 the the DET bam-1807 4 6 contribute contribute NOUN bam-1807 4 7 of of ADP bam-1807 4 8 physical physical ADJ bam-1807 4 9 exercise exercise NOUN bam-1807 4 10 to to ADP bam-1807 4 11 the the DET bam-1807 4 12 shaping shaping NOUN bam-1807 4 13 of of ADP bam-1807 4 14 skeletal skeletal ADJ bam-1807 4 15 muscle muscle NOUN bam-1807 4 16 , , PUNCT bam-1807 4 17 to to ADP bam-1807 4 18 the the DET bam-1807 4 19 adaptation adaptation NOUN bam-1807 4 20 of of ADP bam-1807 4 21 its its PRON bam-1807 4 22 mass mass NOUN bam-1807 4 23 and and CCONJ bam-1807 4 24 function function NOUN bam-1807 4 25 to to ADP bam-1807 4 26 the the DET bam-1807 4 27 different different ADJ bam-1807 4 28 needs need NOUN bam-1807 4 29 imposed impose VERB bam-1807 4 30 by by ADP bam-1807 4 31 different different ADJ bam-1807 4 32 physical physical ADJ bam-1807 4 33 activities activity NOUN bam-1807 4 34 and and CCONJ bam-1807 4 35 to to ADP bam-1807 4 36 the the DET bam-1807 4 37 attainment attainment NOUN bam-1807 4 38 of of ADP bam-1807 4 39 the the DET bam-1807 4 40 health health NOUN bam-1807 4 41 benefits benefit NOUN bam-1807 4 42 associated associate VERB bam-1807 4 43 with with ADP bam-1807 4 44 active active ADJ bam-1807 4 45 skeletal skeletal ADJ bam-1807 4 46 muscles muscle NOUN bam-1807 4 47 . . PUNCT bam-1807 5 1 focus focus NOUN bam-1807 5 2 will will AUX bam-1807 5 3 primarily primarily ADV bam-1807 5 4 be be AUX bam-1807 5 5 on on ADP bam-1807 5 6 the the DET bam-1807 5 7 molecular molecular ADJ bam-1807 5 8 pathways pathway NOUN bam-1807 5 9 and and CCONJ bam-1807 5 10 on on ADP bam-1807 5 11 gene gene NOUN bam-1807 5 12 regulation regulation NOUN bam-1807 5 13 that that PRON bam-1807 5 14 result result VERB bam-1807 5 15 in in ADP bam-1807 5 16 skeletal skeletal ADJ bam-1807 5 17 muscle muscle NOUN bam-1807 5 18 adaptation adaptation NOUN bam-1807 5 19 to to PART bam-1807 5 20 exercise exercise VERB bam-1807 5 21 . . PUNCT bam-1807 6 1 key key ADJ bam-1807 6 2 words word NOUN bam-1807 6 3 : : PUNCT bam-1807 6 4 skeletal skeletal ADJ bam-1807 6 5 muscle muscle NOUN bam-1807 6 6 , , PUNCT bam-1807 6 7 physical physical ADJ bam-1807 6 8 exercise exercise NOUN bam-1807 6 9 , , PUNCT bam-1807 6 10 endurance endurance NOUN bam-1807 6 11 training training NOUN bam-1807 6 12 . . PUNCT bam-1807 7 1 force force NOUN bam-1807 7 2 training training NOUN bam-1807 7 3 , , PUNCT bam-1807 7 4 metabolic metabolic NOUN bam-1807 7 5 adaptation adaptation NOUN bam-1807 7 6 . . PUNCT bam-1807 8 1 european european PROPN bam-1807 8 2 journal journal PROPN bam-1807 8 3 translational translational ADJ bam-1807 8 4 myology myology NOUN bam-1807 8 5 myology myology NOUN bam-1807 8 6 reviews review NOUN bam-1807 8 7 2010 2010 NUM bam-1807 8 8 ; ; PUNCT bam-1807 8 9 20 20 NUM bam-1807 8 10 ( ( PUNCT bam-1807 8 11 3 3 NUM bam-1807 8 12 ): ): PUNCT bam-1807 8 13 105 105 NUM bam-1807 8 14 - - SYM bam-1807 8 15 120 120 NUM bam-1807 8 16 1 1 NUM bam-1807 8 17 . . PUNCT bam-1807 9 1 physical physical ADJ bam-1807 9 2 exercise exercise NOUN bam-1807 9 3 and and CCONJ bam-1807 9 4 exercise exercise NOUN bam-1807 9 5 training train VERB bam-1807 9 6 2 2 NUM bam-1807 9 7 . . PUNCT bam-1807 9 8 fiber fiber NOUN bam-1807 9 9 type type NOUN bam-1807 9 10 diversity diversity NOUN bam-1807 9 11 and and CCONJ bam-1807 9 12 adaptation adaptation NOUN bam-1807 9 13 to to PART bam-1807 9 14 exercise exercise VERB bam-1807 9 15 3 3 NUM bam-1807 9 16 . . PUNCT bam-1807 9 17 exercise exercise NOUN bam-1807 9 18 - - PUNCT bam-1807 9 19 induced induce VERB bam-1807 9 20 muscle muscle NOUN bam-1807 9 21 hypertrophy hypertrophy NOUN bam-1807 9 22 4 4 NUM bam-1807 9 23 . . PUNCT bam-1807 9 24 metabolic metabolic NOUN bam-1807 9 25 adaptation adaptation NOUN bam-1807 9 26 to to PART bam-1807 9 27 exercise exercise VERB bam-1807 9 28 5 5 NUM bam-1807 9 29 . . PUNCT bam-1807 9 30 exercise exercise NOUN bam-1807 9 31 - - PUNCT bam-1807 9 32 induced induce VERB bam-1807 9 33 neo neo NOUN bam-1807 9 34 - - NOUN bam-1807 9 35 angiogenesis angiogenesis NOUN bam-1807 9 36 6 6 NUM bam-1807 9 37 . . PUNCT bam-1807 9 38 adaptation adaptation NOUN bam-1807 9 39 of of ADP bam-1807 9 40 conductive conductive ADJ bam-1807 9 41 apparatus apparatus NOUN bam-1807 9 42 , , PUNCT bam-1807 9 43 sarcoplasmic sarcoplasmic NOUN bam-1807 9 44 reticulum reticulum NOUN bam-1807 9 45 and and CCONJ bam-1807 9 46 other other ADJ bam-1807 9 47 systems system NOUN bam-1807 9 48 7 7 NUM bam-1807 9 49 . . PUNCT bam-1807 9 50 exercise exercise NOUN bam-1807 9 51 and and CCONJ bam-1807 9 52 generation generation NOUN bam-1807 9 53 of of ADP bam-1807 9 54 reactive reactive ADJ bam-1807 9 55 oxygen oxygen NOUN bam-1807 9 56 and and CCONJ bam-1807 9 57 nitrogen nitrogen NOUN bam-1807 9 58 species specie NOUN bam-1807 9 59 ( ( PUNCT bam-1807 9 60 rons ron NOUN bam-1807 9 61 ) ) PUNCT bam-1807 9 62 8 8 NUM bam-1807 9 63 . . PUNCT bam-1807 9 64 exercise exercise NOUN bam-1807 9 65 and and CCONJ bam-1807 9 66 skeletal skeletal ADJ bam-1807 9 67 muscle muscle NOUN bam-1807 9 68 cell cell NOUN bam-1807 9 69 damage damage NOUN bam-1807 9 70 9 9 NUM bam-1807 9 71 . . PUNCT bam-1807 10 1 major major ADJ bam-1807 10 2 pathways pathway NOUN bam-1807 10 3 involved involve VERB bam-1807 10 4 in in ADP bam-1807 10 5 adaptation adaptation NOUN bam-1807 10 6 to to PART bam-1807 10 7 exercise exercise VERB bam-1807 10 8 and and CCONJ bam-1807 10 9 the the DET bam-1807 10 10 phenomenon phenomenon NOUN bam-1807 10 11 of of ADP bam-1807 10 12 concurrent concurrent ADJ bam-1807 10 13 training training NOUN bam-1807 10 14 10 10 NUM bam-1807 10 15 . . PUNCT bam-1807 11 1 muscle muscle NOUN bam-1807 11 2 - - PUNCT bam-1807 11 3 to to ADP bam-1807 11 4 - - PUNCT bam-1807 11 5 body body NOUN bam-1807 11 6 signals signal NOUN bam-1807 11 7 , , PUNCT bam-1807 11 8 hormones hormone NOUN bam-1807 11 9 , , PUNCT bam-1807 11 10 aging age VERB bam-1807 11 11 in in ADP bam-1807 11 12 vertebrates vertebrate NOUN bam-1807 11 13 , , PUNCT bam-1807 11 14 the the DET bam-1807 11 15 skeletal skeletal ADJ bam-1807 11 16 muscle muscle NOUN bam-1807 11 17 is be AUX bam-1807 11 18 characterized characterize VERB bam-1807 11 19 by by ADP bam-1807 11 20 several several ADJ bam-1807 11 21 peculiarities peculiarity NOUN bam-1807 11 22 that that PRON bam-1807 11 23 make make VERB bam-1807 11 24 it it PRON bam-1807 11 25 one one NUM bam-1807 11 26 of of ADP bam-1807 11 27 the the DET bam-1807 11 28 more more ADV bam-1807 11 29 astounding astounding ADJ bam-1807 11 30 tissues tissue NOUN bam-1807 11 31 of of ADP bam-1807 11 32 the the DET bam-1807 11 33 body body NOUN bam-1807 11 34 . . PUNCT bam-1807 12 1 one one NUM bam-1807 12 2 of of ADP bam-1807 12 3 its its PRON bam-1807 12 4 unusual unusual ADJ bam-1807 12 5 characteristics characteristic NOUN bam-1807 12 6 resides reside VERB bam-1807 12 7 in in ADP bam-1807 12 8 its its PRON bam-1807 12 9 being be AUX bam-1807 12 10 highly highly ADV bam-1807 12 11 heterogeneous heterogeneous ADJ bam-1807 12 12 in in ADP bam-1807 12 13 fiber fiber NOUN bam-1807 12 14 type type NOUN bam-1807 12 15 , , PUNCT bam-1807 12 16 so so SCONJ bam-1807 12 17 that that SCONJ bam-1807 12 18 it it PRON bam-1807 12 19 may may AUX bam-1807 12 20 be be AUX bam-1807 12 21 looked look VERB bam-1807 12 22 at at ADP bam-1807 12 23 as as ADP bam-1807 12 24 a a DET bam-1807 12 25 patchwork patchwork NOUN bam-1807 12 26 of of ADP bam-1807 12 27 rather rather ADV bam-1807 12 28 different different ADJ bam-1807 12 29 cells cell NOUN bam-1807 12 30 ; ; PUNCT bam-1807 12 31 another another DET bam-1807 12 32 important important ADJ bam-1807 12 33 feature feature NOUN bam-1807 12 34 is be AUX bam-1807 12 35 its its PRON bam-1807 12 36 being be AUX bam-1807 12 37 made make VERB bam-1807 12 38 up up ADP bam-1807 12 39 of of ADP bam-1807 12 40 multinucleated multinucleate VERB bam-1807 12 41 cells cell NOUN bam-1807 12 42 , , PUNCT bam-1807 12 43 as as ADP bam-1807 12 44 a a DET bam-1807 12 45 result result NOUN bam-1807 12 46 of of ADP bam-1807 12 47 cell cell NOUN bam-1807 12 48 fusion fusion NOUN bam-1807 12 49 events event NOUN bam-1807 12 50 occurring occur VERB bam-1807 12 51 during during ADP bam-1807 12 52 development development NOUN bam-1807 12 53 . . PUNCT bam-1807 13 1 these these DET bam-1807 13 2 factors factor NOUN bam-1807 13 3 contribute contribute VERB bam-1807 13 4 to to PART bam-1807 13 5 make make VERB bam-1807 13 6 the the DET bam-1807 13 7 skeletal skeletal ADJ bam-1807 13 8 muscle muscle NOUN bam-1807 13 9 the the DET bam-1807 13 10 second second ADJ bam-1807 13 11 more more ADJ bam-1807 13 12 plastic plastic ADJ bam-1807 13 13 tissue tissue NOUN bam-1807 13 14 of of ADP bam-1807 13 15 the the DET bam-1807 13 16 body body NOUN bam-1807 13 17 second second ADJ bam-1807 13 18 to to ADP bam-1807 13 19 the the DET bam-1807 13 20 nervous nervous ADJ bam-1807 13 21 tissue tissue NOUN bam-1807 13 22 only only ADV bam-1807 13 23 . . PUNCT bam-1807 14 1 in in ADP bam-1807 14 2 fact fact NOUN bam-1807 14 3 , , PUNCT bam-1807 14 4 skeletal skeletal ADJ bam-1807 14 5 muscle muscle NOUN bam-1807 14 6 structure structure NOUN bam-1807 14 7 and and CCONJ bam-1807 14 8 function function NOUN bam-1807 14 9 can can AUX bam-1807 14 10 adapt adapt VERB bam-1807 14 11 with with ADP bam-1807 14 12 surprisingly surprisingly ADV bam-1807 14 13 easiness easiness ADJ bam-1807 14 14 to to ADP bam-1807 14 15 environmental environmental ADJ bam-1807 14 16 changes change NOUN bam-1807 14 17 and and CCONJ bam-1807 14 18 to to ADP bam-1807 14 19 different different ADJ bam-1807 14 20 stimuli stimulus NOUN bam-1807 14 21 , , PUNCT bam-1807 14 22 ranging range VERB bam-1807 14 23 from from ADP bam-1807 14 24 stimuli stimulus NOUN bam-1807 14 25 modifying modify VERB bam-1807 14 26 its its PRON bam-1807 14 27 contractile contractile NOUN bam-1807 14 28 activity activity NOUN bam-1807 14 29 ( ( PUNCT bam-1807 14 30 inactivity inactivity NOUN bam-1807 14 31 , , PUNCT bam-1807 14 32 endurance endurance NOUN bam-1807 14 33 exercise exercise NOUN bam-1807 14 34 , , PUNCT bam-1807 14 35 denervation denervation NOUN bam-1807 14 36 , , PUNCT bam-1807 14 37 electrical electrical ADJ bam-1807 14 38 stimulation stimulation NOUN bam-1807 14 39 ) ) PUNCT bam-1807 14 40 , , PUNCT bam-1807 14 41 stimuli stimuli VERB bam-1807 14 42 modifying modify VERB bam-1807 14 43 imposed impose VERB bam-1807 14 44 load load NOUN bam-1807 14 45 ( ( PUNCT bam-1807 14 46 resistance resistance NOUN bam-1807 14 47 exercise exercise NOUN bam-1807 14 48 , , PUNCT bam-1807 14 49 unloading unloading NOUN bam-1807 14 50 , , PUNCT bam-1807 14 51 microgravity microgravity NOUN bam-1807 14 52 ) ) PUNCT bam-1807 14 53 and and CCONJ bam-1807 14 54 to to ADP bam-1807 14 55 other other ADJ bam-1807 14 56 environmental environmental ADJ bam-1807 14 57 factors factor NOUN bam-1807 14 58 such such ADJ bam-1807 14 59 as as ADP bam-1807 14 60 heat heat NOUN bam-1807 14 61 , , PUNCT bam-1807 14 62 hypoxia hypoxia NOUN bam-1807 14 63 , , PUNCT bam-1807 14 64 nutrient nutrient NOUN bam-1807 14 65 availability availability NOUN bam-1807 14 66 , , PUNCT bam-1807 14 67 growth growth NOUN bam-1807 14 68 factors factor NOUN bam-1807 14 69 and and CCONJ bam-1807 14 70 inflammation inflammation ADJ bam-1807 14 71 mediators mediator NOUN bam-1807 14 72 . . PUNCT bam-1807 15 1 recent recent ADJ bam-1807 15 2 advances advance NOUN bam-1807 15 3 allow allow VERB bam-1807 15 4 us we PRON bam-1807 15 5 to to PART bam-1807 15 6 understand understand VERB bam-1807 15 7 the the DET bam-1807 15 8 signaling signal VERB bam-1807 15 9 pathways pathway NOUN bam-1807 15 10 which which PRON bam-1807 15 11 mediate mediate VERB bam-1807 15 12 skeletal skeletal ADJ bam-1807 15 13 muscle muscle NOUN bam-1807 15 14 hypertrophy hypertrophy NOUN bam-1807 15 15 and and CCONJ bam-1807 15 16 atrophy atrophy NOUN bam-1807 15 17 [ [ X bam-1807 15 18 98 98 NUM bam-1807 15 19 ] ] PUNCT bam-1807 15 20 . . PUNCT bam-1807 16 1 the the DET bam-1807 16 2 phenomenon phenomenon NOUN bam-1807 16 3 of of ADP bam-1807 16 4 muscle muscle NOUN bam-1807 16 5 plasticity plasticity NOUN bam-1807 16 6 is be AUX bam-1807 16 7 observed observe VERB bam-1807 16 8 in in ADP bam-1807 16 9 all all DET bam-1807 16 10 vertebrates vertebrate NOUN bam-1807 16 11 , , PUNCT bam-1807 16 12 but but CCONJ bam-1807 16 13 it it PRON bam-1807 16 14 displays display VERB bam-1807 16 15 a a DET bam-1807 16 16 great great ADJ bam-1807 16 17 variety variety NOUN bam-1807 16 18 in in ADP bam-1807 16 19 both both DET bam-1807 16 20 responsiveness responsiveness NOUN bam-1807 16 21 to to PART bam-1807 16 22 stimuli stimulus NOUN bam-1807 16 23 and and CCONJ bam-1807 16 24 structure structure NOUN bam-1807 16 25 - - PUNCT bam-1807 16 26 function function NOUN bam-1807 16 27 adaptations adaptation NOUN bam-1807 16 28 . . PUNCT bam-1807 17 1 the the DET bam-1807 17 2 present present ADJ bam-1807 17 3 overview overview NOUN bam-1807 17 4 is be AUX bam-1807 17 5 limited limit VERB bam-1807 17 6 to to ADP bam-1807 17 7 humans human NOUN bam-1807 17 8 and and CCONJ bam-1807 17 9 rodent rodent ADJ bam-1807 17 10 species specie NOUN bam-1807 17 11 , , PUNCT bam-1807 17 12 and and CCONJ bam-1807 17 13 will will AUX bam-1807 17 14 explore explore VERB bam-1807 17 15 the the DET bam-1807 17 16 current current ADJ bam-1807 17 17 state state NOUN bam-1807 17 18 of of ADP bam-1807 17 19 knowledge knowledge NOUN bam-1807 17 20 pertaining pertain VERB bam-1807 17 21 to to PART bam-1807 17 22 exercise exercise VERB bam-1807 17 23 - - PUNCT bam-1807 17 24 related relate VERB bam-1807 17 25 adaptations adaptation NOUN bam-1807 17 26 . . PUNCT bam-1807 18 1 while while SCONJ bam-1807 18 2 it it PRON bam-1807 18 3 is be AUX bam-1807 18 4 expected expect VERB bam-1807 18 5 that that SCONJ bam-1807 18 6 the the DET bam-1807 18 7 same same ADJ bam-1807 18 8 biological biological ADJ bam-1807 18 9 processes process NOUN bam-1807 18 10 take take VERB bam-1807 18 11 place place NOUN bam-1807 18 12 in in ADP bam-1807 18 13 humans human NOUN bam-1807 18 14 and and CCONJ bam-1807 18 15 in in ADP bam-1807 18 16 rodents rodent NOUN bam-1807 18 17 , , PUNCT bam-1807 18 18 flück flück ADJ bam-1807 18 19 and and CCONJ bam-1807 18 20 hoppeler hoppeler ADJ bam-1807 18 21 [ [ X bam-1807 18 22 27 27 NUM bam-1807 18 23 ] ] PUNCT bam-1807 18 24 pointed point VERB bam-1807 18 25 out out ADP bam-1807 18 26 in in ADP bam-1807 18 27 their their PRON bam-1807 18 28 review review NOUN bam-1807 18 29 that that SCONJ bam-1807 18 30 “ " PUNCT bam-1807 18 31 interspecies interspecie VERB bam-1807 18 32 congruency congruency NOUN bam-1807 18 33 of of ADP bam-1807 18 34 adaptive adaptive ADJ bam-1807 18 35 events event NOUN bam-1807 18 36 is be AUX bam-1807 18 37 by by ADP bam-1807 18 38 no no DET bam-1807 18 39 means mean NOUN bam-1807 18 40 absolute absolute ADJ bam-1807 18 41 ” " PUNCT bam-1807 18 42 , , PUNCT bam-1807 18 43 in in ADP bam-1807 18 44 particular particular ADJ bam-1807 18 45 as as SCONJ bam-1807 18 46 the the DET bam-1807 18 47 extent extent NOUN bam-1807 18 48 and and CCONJ bam-1807 18 49 the the DET bam-1807 18 50 kinetics kinetic NOUN bam-1807 18 51 of of ADP bam-1807 18 52 cellular cellular ADJ bam-1807 18 53 events event NOUN bam-1807 18 54 is be AUX bam-1807 18 55 concerned concern VERB bam-1807 18 56 . . PUNCT bam-1807 19 1 as as ADV bam-1807 19 2 far far ADV bam-1807 19 3 as as SCONJ bam-1807 19 4 the the DET bam-1807 19 5 skeletal skeletal ADJ bam-1807 19 6 muscle muscle NOUN bam-1807 19 7 plasticity plasticity NOUN bam-1807 19 8 is be AUX bam-1807 19 9 concerned concern VERB bam-1807 19 10 , , PUNCT bam-1807 19 11 it it PRON bam-1807 19 12 is be AUX bam-1807 19 13 likely likely ADJ bam-1807 19 14 that that SCONJ bam-1807 19 15 the the DET bam-1807 19 16 most most ADV bam-1807 19 17 relevant relevant ADJ bam-1807 19 18 differences difference NOUN bam-1807 19 19 between between ADP bam-1807 19 20 the the DET bam-1807 19 21 two two NUM bam-1807 19 22 models model NOUN bam-1807 19 23 are be AUX bam-1807 19 24 the the DET bam-1807 19 25 age age NOUN bam-1807 19 26 span span NOUN bam-1807 19 27 and and CCONJ bam-1807 19 28 the the DET bam-1807 19 29 metabolic metabolic NOUN bam-1807 19 30 rate rate NOUN bam-1807 19 31 - - PUNCT bam-1807 19 32 to to ADP bam-1807 19 33 - - PUNCT bam-1807 19 34 body body NOUN bam-1807 19 35 mass mass NOUN bam-1807 19 36 relationship relationship NOUN bam-1807 20 1 [ [ X bam-1807 20 2 122 122 NUM bam-1807 20 3 ] ] PUNCT bam-1807 20 4 . . PUNCT bam-1807 21 1 the the DET bam-1807 21 2 purpose purpose NOUN bam-1807 21 3 of of ADP bam-1807 21 4 this this DET bam-1807 21 5 brief brief ADJ bam-1807 21 6 review review NOUN bam-1807 21 7 is be AUX bam-1807 21 8 to to PART bam-1807 21 9 summarize summarize VERB bam-1807 21 10 the the DET bam-1807 21 11 state state NOUN bam-1807 21 12 of of ADP bam-1807 21 13 knowledge knowledge NOUN bam-1807 21 14 about about ADP bam-1807 21 15 exerciseinduced exerciseinduce VERB bam-1807 21 16 muscle muscle NOUN bam-1807 21 17 adaptations adaptation NOUN bam-1807 21 18 ; ; PUNCT bam-1807 21 19 since since SCONJ bam-1807 21 20 the the DET bam-1807 21 21 scientific scientific ADJ bam-1807 21 22 the the DET bam-1807 21 23 exercised exercise VERB bam-1807 21 24 skeletal skeletal ADJ bam-1807 21 25 muscle muscle NOUN bam-1807 21 26 european european PROPN bam-1807 21 27 journal journal PROPN bam-1807 21 28 translational translational ADJ bam-1807 21 29 myology myology NOUN bam-1807 21 30 myology myology NOUN bam-1807 21 31 reviews review VERB bam-1807 21 32 20 20 NUM bam-1807 21 33 ( ( PUNCT bam-1807 21 34 3 3 NUM bam-1807 21 35 ): ): PUNCT bam-1807 21 36 105 105 NUM bam-1807 21 37 - - SYM bam-1807 21 38 120 120 NUM bam-1807 21 39 , , PUNCT bam-1807 21 40 2010 2010 NUM bam-1807 21 41 106 106 NUM bam-1807 21 42 literature literature NOUN bam-1807 21 43 is be AUX bam-1807 21 44 in in ADP bam-1807 21 45 rapid rapid ADJ bam-1807 21 46 expansion expansion NOUN bam-1807 21 47 , , PUNCT bam-1807 21 48 we we PRON bam-1807 21 49 made make VERB bam-1807 21 50 the the DET bam-1807 21 51 choice choice NOUN bam-1807 21 52 of of ADP bam-1807 21 53 limiting limit VERB bam-1807 21 54 the the DET bam-1807 21 55 quoted quote VERB bam-1807 21 56 references reference NOUN bam-1807 21 57 mostly mostly ADV bam-1807 21 58 to to ADP bam-1807 21 59 informative informative ADJ bam-1807 21 60 reviews review NOUN bam-1807 21 61 that that PRON bam-1807 21 62 , , PUNCT bam-1807 21 63 in in ADP bam-1807 21 64 turn turn NOUN bam-1807 21 65 , , PUNCT bam-1807 21 66 will will AUX bam-1807 21 67 address address VERB bam-1807 21 68 to to ADP bam-1807 21 69 the the DET bam-1807 21 70 original original ADJ bam-1807 21 71 sources source NOUN bam-1807 21 72 . . PUNCT bam-1807 22 1 readers reader NOUN bam-1807 22 2 are be AUX bam-1807 22 3 also also ADV bam-1807 22 4 referred refer VERB bam-1807 22 5 to to ADP bam-1807 22 6 excellent excellent ADJ bam-1807 22 7 manuals manual NOUN bam-1807 22 8 addressing address VERB bam-1807 22 9 the the DET bam-1807 22 10 basic basic ADJ bam-1807 22 11 concepts concept NOUN bam-1807 22 12 of of ADP bam-1807 22 13 skeletal skeletal ADJ bam-1807 22 14 muscle muscle NOUN bam-1807 22 15 structure structure NOUN bam-1807 22 16 and and CCONJ bam-1807 22 17 mechanisms mechanism NOUN bam-1807 22 18 of of ADP bam-1807 22 19 contractility contractility NOUN bam-1807 22 20 and and CCONJ bam-1807 22 21 plasticity plasticity NOUN bam-1807 22 22 that that PRON bam-1807 22 23 have have AUX bam-1807 22 24 been be AUX bam-1807 22 25 recently recently ADV bam-1807 22 26 published publish VERB bam-1807 22 27 [ [ PUNCT bam-1807 22 28 50 50 NUM bam-1807 22 29 , , PUNCT bam-1807 22 30 63 63 NUM bam-1807 22 31 ] ] PUNCT bam-1807 22 32 . . PUNCT bam-1807 23 1 1 1 X bam-1807 23 2 . . X bam-1807 23 3 physical physical ADJ bam-1807 23 4 exercise exercise NOUN bam-1807 23 5 and and CCONJ bam-1807 23 6 exercise exercise NOUN bam-1807 23 7 training train VERB bam-1807 23 8 physical physical ADJ bam-1807 23 9 exercises exercise NOUN bam-1807 23 10 affecting affect VERB bam-1807 23 11 the the DET bam-1807 23 12 muscle muscle NOUN bam-1807 23 13 plasticity plasticity NOUN bam-1807 23 14 are be AUX bam-1807 23 15 usually usually ADV bam-1807 23 16 grouped group VERB bam-1807 23 17 into into ADP bam-1807 23 18 two two NUM bam-1807 23 19 broad broad ADJ bam-1807 23 20 categories category NOUN bam-1807 23 21 , , PUNCT bam-1807 23 22 those those DET bam-1807 23 23 increasing increase VERB bam-1807 23 24 muscle muscle NOUN bam-1807 23 25 endurance endurance NOUN bam-1807 23 26 and and CCONJ bam-1807 23 27 those those DET bam-1807 23 28 increasing increase VERB bam-1807 23 29 muscle muscle NOUN bam-1807 23 30 strength strength NOUN bam-1807 23 31 . . PUNCT bam-1807 24 1 muscle muscle NOUN bam-1807 24 2 endurance endurance NOUN bam-1807 24 3 , , PUNCT bam-1807 24 4 as as ADP bam-1807 24 5 the the DET bam-1807 24 6 ability ability NOUN bam-1807 24 7 of of ADP bam-1807 24 8 muscle muscle NOUN bam-1807 24 9 to to PART bam-1807 24 10 sustain sustain VERB bam-1807 24 11 repeated repeat VERB bam-1807 24 12 efforts effort NOUN bam-1807 24 13 of of ADP bam-1807 24 14 relatively relatively ADV bam-1807 24 15 low low ADJ bam-1807 24 16 intensity intensity NOUN bam-1807 24 17 for for ADP bam-1807 24 18 long long ADJ bam-1807 24 19 periods period NOUN bam-1807 24 20 of of ADP bam-1807 24 21 time time NOUN bam-1807 24 22 , , PUNCT bam-1807 24 23 is be AUX bam-1807 24 24 also also ADV bam-1807 24 25 related relate VERB bam-1807 24 26 to to ADP bam-1807 24 27 the the DET bam-1807 24 28 body body NOUN bam-1807 24 29 aerobic aerobic ADJ bam-1807 24 30 capacity capacity NOUN bam-1807 24 31 , , PUNCT bam-1807 24 32 i.e. i.e. X bam-1807 24 33 the the DET bam-1807 24 34 efficiency efficiency NOUN bam-1807 24 35 of of ADP bam-1807 24 36 the the DET bam-1807 24 37 cardiovascular cardiovascular ADJ bam-1807 24 38 and and CCONJ bam-1807 24 39 respiratory respiratory ADJ bam-1807 24 40 system system NOUN bam-1807 24 41 in in ADP bam-1807 24 42 assuming assume VERB bam-1807 24 43 and and CCONJ bam-1807 24 44 transporting transport VERB bam-1807 24 45 oxygen oxygen NOUN bam-1807 24 46 . . PUNCT bam-1807 25 1 highly highly ADV bam-1807 25 2 repetitive repetitive ADJ bam-1807 25 3 , , PUNCT bam-1807 25 4 low low ADJ bam-1807 25 5 - - PUNCT bam-1807 25 6 load load NOUN bam-1807 25 7 exercises exercise NOUN bam-1807 25 8 favor favor VERB bam-1807 25 9 the the DET bam-1807 25 10 adaptation adaptation NOUN bam-1807 25 11 of of ADP bam-1807 25 12 muscles muscle NOUN bam-1807 25 13 to to ADP bam-1807 25 14 a a DET bam-1807 25 15 fatigueresistant fatigueresistant ADJ bam-1807 25 16 phenotype phenotype NOUN bam-1807 25 17 . . PUNCT bam-1807 26 1 on on ADP bam-1807 26 2 the the DET bam-1807 26 3 other other ADJ bam-1807 26 4 hand hand NOUN bam-1807 26 5 , , PUNCT bam-1807 26 6 muscle muscle NOUN bam-1807 26 7 strength strength NOUN bam-1807 26 8 is be AUX bam-1807 26 9 the the DET bam-1807 26 10 ability ability NOUN bam-1807 26 11 of of ADP bam-1807 26 12 muscles muscle NOUN bam-1807 26 13 to to PART bam-1807 26 14 overcome overcome VERB bam-1807 26 15 a a DET bam-1807 26 16 resistance resistance NOUN bam-1807 26 17 . . PUNCT bam-1807 27 1 this this DET bam-1807 27 2 ability ability NOUN bam-1807 27 3 is be AUX bam-1807 27 4 built build VERB bam-1807 27 5 up up ADP bam-1807 27 6 by by ADP bam-1807 27 7 increasing increase VERB bam-1807 27 8 muscle muscle NOUN bam-1807 27 9 load load NOUN bam-1807 27 10 rather rather ADV bam-1807 27 11 than than ADP bam-1807 27 12 by by ADP bam-1807 27 13 increasing increase VERB bam-1807 27 14 the the DET bam-1807 27 15 number number NOUN bam-1807 27 16 of of ADP bam-1807 27 17 repetitions repetition NOUN bam-1807 27 18 of of ADP bam-1807 27 19 exercise exercise NOUN bam-1807 27 20 and and CCONJ bam-1807 27 21 is be AUX bam-1807 27 22 supported support VERB bam-1807 27 23 by by ADP bam-1807 27 24 fiber fiber NOUN bam-1807 27 25 hypertrophy hypertrophy NOUN bam-1807 27 26 . . PUNCT bam-1807 28 1 it it PRON bam-1807 28 2 mostly mostly ADV bam-1807 28 3 relies rely VERB bam-1807 28 4 on on ADP bam-1807 28 5 the the DET bam-1807 28 6 glycolytic glycolytic ADJ bam-1807 28 7 metabolism metabolism NOUN bam-1807 28 8 , , PUNCT bam-1807 28 9 so so SCONJ bam-1807 28 10 that that SCONJ bam-1807 28 11 resistance resistance NOUN bam-1807 28 12 training training NOUN bam-1807 28 13 only only ADV bam-1807 28 14 slightly slightly ADV bam-1807 28 15 improves improve VERB bam-1807 28 16 the the DET bam-1807 28 17 aerobic aerobic ADJ bam-1807 28 18 fitness fitness NOUN bam-1807 28 19 and and CCONJ bam-1807 28 20 contributes contribute VERB bam-1807 28 21 only only ADV bam-1807 28 22 marginally marginally ADV bam-1807 28 23 to to ADP bam-1807 28 24 the the DET bam-1807 28 25 maintenance maintenance NOUN bam-1807 28 26 of of ADP bam-1807 28 27 cardiovascular cardiovascular ADJ bam-1807 28 28 health health NOUN bam-1807 29 1 [ [ X bam-1807 29 2 4 4 NUM bam-1807 29 3 ] ] PUNCT bam-1807 29 4 . . PUNCT bam-1807 30 1 when when SCONJ bam-1807 30 2 considering consider VERB bam-1807 30 3 the the DET bam-1807 30 4 exercise exercise NOUN bam-1807 30 5 affecting affect VERB bam-1807 30 6 the the DET bam-1807 30 7 phenotypic phenotypic ADJ bam-1807 30 8 adaptations adaptation NOUN bam-1807 30 9 of of ADP bam-1807 30 10 muscle muscle NOUN bam-1807 30 11 , , PUNCT bam-1807 30 12 the the DET bam-1807 30 13 variables variable NOUN bam-1807 30 14 are be AUX bam-1807 30 15 frequency frequency NOUN bam-1807 30 16 , , PUNCT bam-1807 30 17 intensity intensity NOUN bam-1807 30 18 , , PUNCT bam-1807 30 19 and and CCONJ bam-1807 30 20 time time NOUN bam-1807 30 21 ( ( PUNCT bam-1807 30 22 duration duration NOUN bam-1807 30 23 ) ) PUNCT bam-1807 30 24 , , PUNCT bam-1807 30 25 hence hence ADV bam-1807 30 26 the the DET bam-1807 30 27 socalled socalled ADJ bam-1807 30 28 “ " PUNCT bam-1807 30 29 fit fit ADJ bam-1807 30 30 principle principle NOUN bam-1807 30 31 ” " PUNCT bam-1807 30 32 , , PUNCT bam-1807 30 33 which which PRON bam-1807 30 34 popularly popularly ADV bam-1807 30 35 describes describe VERB bam-1807 30 36 the the DET bam-1807 30 37 fact fact NOUN bam-1807 30 38 that that SCONJ bam-1807 30 39 their their PRON bam-1807 30 40 combination combination NOUN bam-1807 30 41 will will AUX bam-1807 30 42 also also ADV bam-1807 30 43 determine determine VERB bam-1807 30 44 the the DET bam-1807 30 45 molecular molecular ADJ bam-1807 30 46 pathways pathway NOUN bam-1807 30 47 that that PRON bam-1807 30 48 are be AUX bam-1807 30 49 activated activate VERB bam-1807 30 50 in in ADP bam-1807 30 51 response response NOUN bam-1807 30 52 to to PART bam-1807 30 53 exercise exercise VERB bam-1807 30 54 and and CCONJ bam-1807 30 55 , , PUNCT bam-1807 30 56 therefore therefore ADV bam-1807 30 57 , , PUNCT bam-1807 30 58 determine determine VERB bam-1807 30 59 the the DET bam-1807 30 60 final final ADJ bam-1807 30 61 output output NOUN bam-1807 30 62 in in ADP bam-1807 30 63 terms term NOUN bam-1807 30 64 of of ADP bam-1807 30 65 endurance endurance NOUN bam-1807 30 66 and and CCONJ bam-1807 30 67 strength strength NOUN bam-1807 30 68 or or CCONJ bam-1807 30 69 some some DET bam-1807 30 70 combination combination NOUN bam-1807 30 71 of of ADP bam-1807 30 72 the the DET bam-1807 30 73 two two NUM bam-1807 30 74 . . PUNCT bam-1807 31 1 as as SCONJ bam-1807 31 2 baar baar PROPN bam-1807 31 3 [ [ X bam-1807 31 4 6 6 NUM bam-1807 31 5 ] ] PUNCT bam-1807 31 6 points point NOUN bam-1807 31 7 out out ADP bam-1807 31 8 , , PUNCT bam-1807 31 9 the the DET bam-1807 31 10 high high ADJ bam-1807 31 11 - - PUNCT bam-1807 31 12 intensity intensity NOUN bam-1807 31 13 training training NOUN bam-1807 31 14 ( ( PUNCT bam-1807 31 15 hit hit NOUN bam-1807 31 16 ) ) PUNCT bam-1807 31 17 studies study NOUN bam-1807 31 18 performed perform VERB bam-1807 31 19 in in ADP bam-1807 31 20 animals animal NOUN bam-1807 31 21 by by ADP bam-1807 31 22 terada terada PROPN bam-1807 31 23 et et PROPN bam-1807 31 24 al al PROPN bam-1807 31 25 . . PUNCT bam-1807 32 1 [ [ X bam-1807 32 2 112 112 NUM bam-1807 32 3 ] ] PUNCT bam-1807 32 4 and and CCONJ bam-1807 32 5 in in ADP bam-1807 32 6 humans human NOUN bam-1807 32 7 by by ADP bam-1807 32 8 gibala gibala NOUN bam-1807 32 9 et et NOUN bam-1807 32 10 al al PROPN bam-1807 32 11 . . PUNCT bam-1807 33 1 [ [ X bam-1807 33 2 31 31 NUM bam-1807 33 3 ] ] PUNCT bam-1807 33 4 show show VERB bam-1807 33 5 that that SCONJ bam-1807 33 6 the the DET bam-1807 33 7 adaptation adaptation NOUN bam-1807 33 8 to to ADP bam-1807 33 9 low low ADJ bam-1807 33 10 intensity intensity NOUN bam-1807 33 11 and and CCONJ bam-1807 33 12 long long ADJ bam-1807 33 13 time time NOUN bam-1807 33 14 ( ( PUNCT bam-1807 33 15 duration duration NOUN bam-1807 33 16 ) ) PUNCT bam-1807 33 17 training training NOUN bam-1807 33 18 was be AUX bam-1807 33 19 the the DET bam-1807 33 20 same same ADJ bam-1807 33 21 as as ADP bam-1807 33 22 training training NOUN bam-1807 33 23 at at ADP bam-1807 33 24 high high ADJ bam-1807 33 25 intensity intensity NOUN bam-1807 33 26 and and CCONJ bam-1807 33 27 short short ADJ bam-1807 33 28 time time NOUN bam-1807 33 29 ( ( PUNCT bam-1807 33 30 duration duration NOUN bam-1807 33 31 ) ) PUNCT bam-1807 33 32 , , PUNCT bam-1807 33 33 i.e. i.e. X bam-1807 33 34 it it PRON bam-1807 33 35 is be AUX bam-1807 33 36 dependent dependent ADJ bam-1807 33 37 on on ADP bam-1807 33 38 the the DET bam-1807 33 39 volume volume NOUN bam-1807 33 40 of of ADP bam-1807 33 41 exercise exercise NOUN bam-1807 33 42 . . PUNCT bam-1807 34 1 thus thus ADV bam-1807 34 2 , , PUNCT bam-1807 34 3 baar baar PROPN bam-1807 34 4 focuses focus VERB bam-1807 34 5 on on ADP bam-1807 34 6 how how SCONJ bam-1807 34 7 variations variation NOUN bam-1807 34 8 in in ADP bam-1807 34 9 load load NOUN bam-1807 34 10 , , PUNCT bam-1807 34 11 metabolic metabolic NOUN bam-1807 34 12 stress stress NOUN bam-1807 34 13 , , PUNCT bam-1807 34 14 and and CCONJ bam-1807 34 15 calcium calcium NOUN bam-1807 34 16 flux flux NOUN bam-1807 34 17 are be AUX bam-1807 34 18 transduced transduce VERB bam-1807 34 19 to to ADP bam-1807 34 20 increases increase NOUN bam-1807 34 21 in in ADP bam-1807 34 22 muscle muscle NOUN bam-1807 34 23 mass mass NOUN bam-1807 34 24 and and CCONJ bam-1807 34 25 endurance endurance NOUN bam-1807 34 26 capacity capacity NOUN bam-1807 34 27 . . PUNCT bam-1807 35 1 summarizing summarize VERB bam-1807 35 2 baar baar PROPN bam-1807 35 3 's 's PART bam-1807 35 4 hypothesis hypothesis NOUN bam-1807 35 5 , , PUNCT bam-1807 35 6 if if SCONJ bam-1807 35 7 the the DET bam-1807 35 8 load load NOUN bam-1807 35 9 is be AUX bam-1807 35 10 high high ADJ bam-1807 35 11 and and CCONJ bam-1807 35 12 the the DET bam-1807 35 13 metabolic metabolic NOUN bam-1807 35 14 stress stress NOUN bam-1807 35 15 and and CCONJ bam-1807 35 16 calcium calcium NOUN bam-1807 35 17 flux flux NOUN bam-1807 35 18 are be AUX bam-1807 35 19 low low ADJ bam-1807 35 20 , , PUNCT bam-1807 35 21 the the DET bam-1807 35 22 primary primary ADJ bam-1807 35 23 response response NOUN bam-1807 35 24 will will AUX bam-1807 35 25 be be AUX bam-1807 35 26 an an DET bam-1807 35 27 increase increase NOUN bam-1807 35 28 in in ADP bam-1807 35 29 the the DET bam-1807 35 30 rate rate NOUN bam-1807 35 31 of of ADP bam-1807 35 32 protein protein NOUN bam-1807 35 33 synthesis synthesis NOUN bam-1807 35 34 and and CCONJ bam-1807 35 35 an an DET bam-1807 35 36 altered altered ADJ bam-1807 35 37 transcriptional transcriptional NOUN bam-1807 35 38 profile profile NOUN bam-1807 35 39 , , PUNCT bam-1807 35 40 resulting result VERB bam-1807 35 41 in in ADP bam-1807 35 42 skeletal skeletal ADJ bam-1807 35 43 muscle muscle NOUN bam-1807 35 44 hypertrophy hypertrophy NOUN bam-1807 35 45 and and CCONJ bam-1807 35 46 increased increase VERB bam-1807 35 47 strength strength NOUN bam-1807 35 48 . . PUNCT bam-1807 36 1 if if SCONJ bam-1807 36 2 the the DET bam-1807 36 3 metabolic metabolic NOUN bam-1807 36 4 stress stress NOUN bam-1807 36 5 and and CCONJ bam-1807 36 6 calcium calcium NOUN bam-1807 36 7 flux flux NOUN bam-1807 36 8 are be AUX bam-1807 36 9 high high ADJ bam-1807 36 10 , , PUNCT bam-1807 36 11 the the DET bam-1807 36 12 primary primary ADJ bam-1807 36 13 response response NOUN bam-1807 36 14 will will AUX bam-1807 36 15 be be AUX bam-1807 36 16 increased increase VERB bam-1807 36 17 mitochondrial mitochondrial ADJ bam-1807 36 18 mass mass NOUN bam-1807 36 19 and and CCONJ bam-1807 36 20 oxidative oxidative ADJ bam-1807 36 21 enzymes enzyme NOUN bam-1807 36 22 , , PUNCT bam-1807 36 23 resulting result VERB bam-1807 36 24 in in ADP bam-1807 36 25 improved improved ADJ bam-1807 36 26 fatigue fatigue NOUN bam-1807 36 27 resistance resistance NOUN bam-1807 36 28 . . PUNCT bam-1807 37 1 we we PRON bam-1807 37 2 will will AUX bam-1807 37 3 discuss discuss VERB bam-1807 37 4 in in ADP bam-1807 37 5 a a DET bam-1807 37 6 later later ADJ bam-1807 37 7 section section NOUN bam-1807 37 8 the the DET bam-1807 37 9 molecular molecular ADJ bam-1807 37 10 pathways pathway NOUN bam-1807 37 11 that that PRON bam-1807 37 12 are be AUX bam-1807 37 13 selectively selectively ADV bam-1807 37 14 activated activate VERB bam-1807 37 15 and and CCONJ bam-1807 37 16 lead lead VERB bam-1807 37 17 to to ADP bam-1807 37 18 the the DET bam-1807 37 19 specific specific ADJ bam-1807 37 20 adaptive adaptive ADJ bam-1807 37 21 responses response NOUN bam-1807 37 22 to to ADP bam-1807 37 23 endurance endurance NOUN bam-1807 37 24 or or CCONJ bam-1807 37 25 resistance resistance NOUN bam-1807 37 26 training training NOUN bam-1807 37 27 and and CCONJ bam-1807 37 28 their their PRON bam-1807 37 29 possible possible ADJ bam-1807 37 30 interferences interference NOUN bam-1807 37 31 ( ( PUNCT bam-1807 37 32 see see VERB bam-1807 37 33 , , PUNCT bam-1807 37 34 for for ADP bam-1807 37 35 instance instance NOUN bam-1807 37 36 , , PUNCT bam-1807 37 37 [ [ X bam-1807 37 38 5 5 NUM bam-1807 37 39 , , PUNCT bam-1807 37 40 36 36 NUM bam-1807 37 41 ] ] NUM bam-1807 37 42 ) ) PUNCT bam-1807 37 43 . . PUNCT bam-1807 38 1 2 2 X bam-1807 38 2 . . X bam-1807 38 3 fiber fiber NOUN bam-1807 38 4 type type NOUN bam-1807 38 5 diversity diversity NOUN bam-1807 38 6 and and CCONJ bam-1807 38 7 adaptation adaptation NOUN bam-1807 38 8 to to PART bam-1807 38 9 exercise exercise VERB bam-1807 38 10 in in ADP bam-1807 38 11 the the DET bam-1807 38 12 mammals mammal NOUN bam-1807 38 13 , , PUNCT bam-1807 38 14 skeletal skeletal ADJ bam-1807 38 15 muscles muscle NOUN bam-1807 38 16 are be AUX bam-1807 38 17 constituted constitute VERB bam-1807 38 18 of of ADP bam-1807 38 19 a a DET bam-1807 38 20 variety variety NOUN bam-1807 38 21 of of ADP bam-1807 38 22 fiber fiber NOUN bam-1807 38 23 types type NOUN bam-1807 38 24 , , PUNCT bam-1807 38 25 characterized characterize VERB bam-1807 38 26 by by ADP bam-1807 38 27 different different ADJ bam-1807 38 28 structural structural ADJ bam-1807 38 29 and and CCONJ bam-1807 38 30 functional functional ADJ bam-1807 38 31 properties property NOUN bam-1807 38 32 . . PUNCT bam-1807 39 1 their their PRON bam-1807 39 2 classification classification NOUN bam-1807 39 3 , , PUNCT bam-1807 39 4 in in ADP bam-1807 39 5 order order NOUN bam-1807 39 6 of of ADP bam-1807 39 7 increasing increase VERB bam-1807 39 8 contractile contractile NOUN bam-1807 39 9 speed speed NOUN bam-1807 39 10 and and CCONJ bam-1807 39 11 of of ADP bam-1807 39 12 decreasing decrease VERB bam-1807 39 13 reliance reliance NOUN bam-1807 39 14 on on ADP bam-1807 39 15 the the DET bam-1807 39 16 oxidative oxidative ADJ bam-1807 39 17 metabolism metabolism NOUN bam-1807 39 18 in in ADP bam-1807 39 19 favor favor NOUN bam-1807 39 20 of of ADP bam-1807 39 21 a a DET bam-1807 39 22 glycolytic glycolytic ADJ bam-1807 39 23 one one NOUN bam-1807 39 24 , , PUNCT bam-1807 39 25 subdivides subdivide VERB bam-1807 39 26 the the DET bam-1807 39 27 skeletal skeletal ADJ bam-1807 39 28 fibers fiber NOUN bam-1807 39 29 in in ADP bam-1807 39 30 four four NUM bam-1807 39 31 major major ADJ bam-1807 39 32 subtypes subtype NOUN bam-1807 39 33 , , PUNCT bam-1807 39 34 which which PRON bam-1807 39 35 are be AUX bam-1807 39 36 named name VERB bam-1807 39 37 after after SCONJ bam-1807 39 38 the the DET bam-1807 39 39 myosin myosin PROPN bam-1807 39 40 heavy heavy PROPN bam-1807 39 41 chain chain NOUN bam-1807 39 42 ( ( PUNCT bam-1807 39 43 mhc mhc PROPN bam-1807 39 44 ) ) PUNCT bam-1807 39 45 isoforms isoform VERB bam-1807 39 46 they they PRON bam-1807 39 47 express express VERB bam-1807 39 48 . . PUNCT bam-1807 40 1 type type NOUN bam-1807 40 2 i i PRON bam-1807 40 3 , , PUNCT bam-1807 40 4 slow slow ADJ bam-1807 40 5 - - PUNCT bam-1807 40 6 twitch twitch NOUN bam-1807 40 7 muscles muscle NOUN bam-1807 40 8 are be AUX bam-1807 40 9 specialized specialize VERB bam-1807 40 10 for for ADP bam-1807 40 11 a a DET bam-1807 40 12 more more ADV bam-1807 40 13 continuous continuous ADJ bam-1807 40 14 activity activity NOUN bam-1807 40 15 and and CCONJ bam-1807 40 16 a a DET bam-1807 40 17 fatigue fatigue NOUN bam-1807 40 18 - - PUNCT bam-1807 40 19 resistant resistant ADJ bam-1807 40 20 phenotype phenotype NOUN bam-1807 40 21 and and CCONJ bam-1807 40 22 exploit exploit VERB bam-1807 40 23 an an DET bam-1807 40 24 oxidative oxidative ADJ bam-1807 40 25 metabolism metabolism NOUN bam-1807 40 26 ; ; PUNCT bam-1807 40 27 they they PRON bam-1807 40 28 are be AUX bam-1807 40 29 endowed endow VERB bam-1807 40 30 of of ADP bam-1807 40 31 a a DET bam-1807 40 32 high high ADJ bam-1807 40 33 mitochondrial mitochondrial ADJ bam-1807 40 34 content content NOUN bam-1807 40 35 and and CCONJ bam-1807 40 36 a a DET bam-1807 40 37 rich rich ADJ bam-1807 40 38 capillary capillary ADJ bam-1807 40 39 bed bed NOUN bam-1807 40 40 , , PUNCT bam-1807 40 41 so so SCONJ bam-1807 40 42 that that SCONJ bam-1807 40 43 they they PRON bam-1807 40 44 macroscopically macroscopically ADV bam-1807 40 45 appear appear VERB bam-1807 40 46 red red ADJ bam-1807 40 47 . . PUNCT bam-1807 41 1 type type NOUN bam-1807 41 2 iia iia NOUN bam-1807 41 3 fibers fiber NOUN bam-1807 41 4 are be AUX bam-1807 41 5 rich rich ADJ bam-1807 41 6 in in ADP bam-1807 41 7 mitochondria mitochondria NOUN bam-1807 41 8 and and CCONJ bam-1807 41 9 capillaries capillary NOUN bam-1807 41 10 , , PUNCT bam-1807 41 11 so so SCONJ bam-1807 41 12 that that SCONJ bam-1807 41 13 they they PRON bam-1807 41 14 too too ADV bam-1807 41 15 appear appear VERB bam-1807 41 16 red red ADJ bam-1807 41 17 ; ; PUNCT bam-1807 41 18 they they PRON bam-1807 41 19 stain stain VERB bam-1807 41 20 strongly strongly ADV bam-1807 41 21 for for ADP bam-1807 41 22 succinate succinate ADJ bam-1807 41 23 dehydrogenase dehydrogenase NOUN bam-1807 41 24 ( ( PUNCT bam-1807 41 25 sdh sdh PROPN bam-1807 41 26 ) ) PUNCT bam-1807 41 27 but but CCONJ bam-1807 41 28 are be AUX bam-1807 41 29 also also ADV bam-1807 41 30 rich rich ADJ bam-1807 41 31 in in ADP bam-1807 41 32 glycolytic glycolytic ADJ bam-1807 41 33 enzymes enzyme NOUN bam-1807 41 34 , , PUNCT bam-1807 41 35 so so SCONJ bam-1807 41 36 that that SCONJ bam-1807 41 37 they they PRON bam-1807 41 38 are be AUX bam-1807 41 39 also also ADV bam-1807 41 40 classified classify VERB bam-1807 41 41 as as ADP bam-1807 41 42 fast fast ADJ bam-1807 41 43 - - PUNCT bam-1807 41 44 twitch twitch NOUN bam-1807 41 45 oxidative oxidative ADJ bam-1807 41 46 glycolytic glycolytic ADJ bam-1807 41 47 fibers fiber NOUN bam-1807 41 48 and and CCONJ bam-1807 41 49 constitute constitute VERB bam-1807 41 50 fast fast ADJ bam-1807 41 51 fatigue fatigue NOUN bam-1807 41 52 - - PUNCT bam-1807 41 53 resistant resistant ADJ bam-1807 41 54 units unit NOUN bam-1807 41 55 . . PUNCT bam-1807 42 1 type type NOUN bam-1807 42 2 iix iix PROPN bam-1807 42 3 ( ( PUNCT bam-1807 42 4 also also ADV bam-1807 42 5 called call VERB bam-1807 42 6 iid iid NOUN bam-1807 42 7 ) ) PUNCT bam-1807 42 8 fibers fiber NOUN bam-1807 42 9 are be AUX bam-1807 42 10 characterized characterize VERB bam-1807 42 11 by by ADP bam-1807 42 12 a a DET bam-1807 42 13 more more ADV bam-1807 42 14 glycolytic glycolytic ADJ bam-1807 42 15 metabolism metabolism NOUN bam-1807 42 16 ; ; PUNCT bam-1807 42 17 in in ADP bam-1807 42 18 rat rat NOUN bam-1807 42 19 skeletal skeletal ADJ bam-1807 42 20 muscle muscle NOUN bam-1807 42 21 , , PUNCT bam-1807 42 22 type type NOUN bam-1807 42 23 iix iix PROPN bam-1807 42 24 fibers fiber NOUN bam-1807 42 25 stain stain VERB bam-1807 42 26 strongly strongly ADV bam-1807 42 27 for for ADP bam-1807 42 28 sdh sdh PROPN bam-1807 42 29 and and CCONJ bam-1807 42 30 are be AUX bam-1807 42 31 characterized characterize VERB bam-1807 42 32 by by ADP bam-1807 42 33 a a DET bam-1807 42 34 velocity velocity NOUN bam-1807 42 35 of of ADP bam-1807 42 36 shortening shortening NOUN bam-1807 42 37 intermediate intermediate ADJ bam-1807 42 38 between between ADP bam-1807 42 39 type type NOUN bam-1807 42 40 iia iia NOUN bam-1807 42 41 and and CCONJ bam-1807 42 42 iib iib NOUN bam-1807 42 43 , , PUNCT bam-1807 42 44 while while SCONJ bam-1807 42 45 in in ADP bam-1807 42 46 humans human NOUN bam-1807 42 47 their their PRON bam-1807 42 48 staining stain VERB bam-1807 42 49 for for ADP bam-1807 42 50 sdh sdh PROPN bam-1807 42 51 is be AUX bam-1807 42 52 the the DET bam-1807 42 53 weakest weak ADJ bam-1807 42 54 , , PUNCT bam-1807 42 55 since since SCONJ bam-1807 42 56 they they PRON bam-1807 42 57 mostly mostly ADV bam-1807 42 58 rely rely VERB bam-1807 42 59 on on ADP bam-1807 42 60 the the DET bam-1807 42 61 glycolytic glycolytic ADJ bam-1807 42 62 metabolism metabolism NOUN bam-1807 42 63 ; ; PUNCT bam-1807 42 64 thus thus ADV bam-1807 42 65 , , PUNCT bam-1807 42 66 in in ADP bam-1807 42 67 humans human NOUN bam-1807 42 68 , , PUNCT bam-1807 42 69 type type NOUN bam-1807 42 70 iix iix PROPN bam-1807 42 71 fibers fiber NOUN bam-1807 42 72 are be AUX bam-1807 42 73 the the DET bam-1807 42 74 fastest fast ADJ bam-1807 42 75 and and CCONJ bam-1807 42 76 the the DET bam-1807 42 77 most most ADV bam-1807 42 78 fatigable fatigable ADJ bam-1807 42 79 ones one NOUN bam-1807 42 80 . . PUNCT bam-1807 43 1 type type NOUN bam-1807 43 2 iib iib PROPN bam-1807 43 3 fibers fiber NOUN bam-1807 43 4 constitute constitute VERB bam-1807 43 5 the the DET bam-1807 43 6 most most ADV bam-1807 43 7 glycolytic glycolytic ADJ bam-1807 43 8 and and CCONJ bam-1807 43 9 fastest fast ADJ bam-1807 43 10 fibers fiber NOUN bam-1807 43 11 in in ADP bam-1807 43 12 rodents rodent NOUN bam-1807 43 13 ( ( PUNCT bam-1807 43 14 white white ADJ bam-1807 43 15 , , PUNCT bam-1807 43 16 fasttwitch fasttwitch ADJ bam-1807 43 17 glycolytic glycolytic ADJ bam-1807 43 18 fibers fiber NOUN bam-1807 43 19 ) ) PUNCT bam-1807 43 20 ; ; PUNCT bam-1807 43 21 in in ADP bam-1807 43 22 humans human NOUN bam-1807 43 23 , , PUNCT bam-1807 43 24 mhc mhc PROPN bam-1807 43 25 iib iib PROPN bam-1807 43 26 is be AUX bam-1807 43 27 not not PART bam-1807 43 28 expressed express VERB bam-1807 43 29 . . PUNCT bam-1807 44 1 immunohistochemistry immunohistochemistry NOUN bam-1807 44 2 and and CCONJ bam-1807 44 3 other other ADJ bam-1807 44 4 methods method NOUN bam-1807 44 5 showed show VERB bam-1807 44 6 that that SCONJ bam-1807 44 7 muscles muscle NOUN bam-1807 44 8 are be AUX bam-1807 44 9 made make VERB bam-1807 44 10 up up ADP bam-1807 44 11 of of ADP bam-1807 44 12 a a DET bam-1807 44 13 mosaic mosaic ADJ bam-1807 44 14 ( ( PUNCT bam-1807 44 15 or or CCONJ bam-1807 44 16 spectrum spectrum NOUN bam-1807 44 17 ) ) PUNCT bam-1807 44 18 of of ADP bam-1807 44 19 fiber fiber NOUN bam-1807 44 20 types type NOUN bam-1807 44 21 with with ADP bam-1807 44 22 pure pure ADJ bam-1807 44 23 or or CCONJ bam-1807 44 24 hybrid hybrid ADJ bam-1807 44 25 mhc mhc NOUN bam-1807 44 26 composition composition NOUN bam-1807 44 27 [ [ X bam-1807 44 28 100 100 NUM bam-1807 44 29 ] ] PUNCT bam-1807 44 30 . . PUNCT bam-1807 45 1 the the DET bam-1807 45 2 pattern pattern NOUN bam-1807 45 3 of of ADP bam-1807 45 4 fiber fiber NOUN bam-1807 45 5 type type NOUN bam-1807 45 6 which which PRON bam-1807 45 7 characterizes characterize VERB bam-1807 45 8 each each DET bam-1807 45 9 single single ADJ bam-1807 45 10 muscle muscle NOUN bam-1807 45 11 is be AUX bam-1807 45 12 initially initially ADV bam-1807 45 13 established establish VERB bam-1807 45 14 during during ADP bam-1807 45 15 development development NOUN bam-1807 45 16 , , PUNCT bam-1807 45 17 but but CCONJ bam-1807 45 18 is be AUX bam-1807 45 19 maintained maintain VERB bam-1807 45 20 through through ADP bam-1807 45 21 adult adult NOUN bam-1807 45 22 life life NOUN bam-1807 45 23 or or CCONJ bam-1807 45 24 shifted shift VERB bam-1807 45 25 toward toward ADP bam-1807 45 26 a a DET bam-1807 45 27 different different ADJ bam-1807 45 28 one one NUM bam-1807 45 29 by by ADP bam-1807 45 30 nerve nerve NOUN bam-1807 45 31 activity activity NOUN bam-1807 45 32 and and CCONJ bam-1807 45 33 by by ADP bam-1807 45 34 thyroid thyroid NOUN bam-1807 45 35 hormone hormone NOUN bam-1807 45 36 . . PUNCT bam-1807 46 1 muscle muscle NOUN bam-1807 46 2 mechanical mechanical ADJ bam-1807 46 3 activity activity NOUN bam-1807 46 4 induces induce VERB bam-1807 46 5 a a DET bam-1807 46 6 switch switch NOUN bam-1807 46 7 in in ADP bam-1807 46 8 the the DET bam-1807 46 9 expression expression NOUN bam-1807 46 10 of of ADP bam-1807 46 11 myosin myosin PROPN bam-1807 46 12 heavy heavy PROPN bam-1807 46 13 chain chain NOUN bam-1807 46 14 genes gene NOUN bam-1807 46 15 , , PUNCT bam-1807 46 16 therefore therefore ADV bam-1807 46 17 contributing contribute VERB bam-1807 46 18 to to ADP bam-1807 46 19 the the DET bam-1807 46 20 adaptation adaptation NOUN bam-1807 46 21 of of ADP bam-1807 46 22 the the DET bam-1807 46 23 muscle muscle NOUN bam-1807 46 24 to to ADP bam-1807 46 25 a a DET bam-1807 46 26 given give VERB bam-1807 46 27 type type NOUN bam-1807 46 28 of of ADP bam-1807 46 29 physical physical ADJ bam-1807 46 30 activity activity NOUN bam-1807 46 31 . . PUNCT bam-1807 47 1 chronic chronic ADJ bam-1807 47 2 phasic phasic VERB bam-1807 47 3 high high ADJ bam-1807 47 4 - - PUNCT bam-1807 47 5 frequency frequency NOUN bam-1807 47 6 electrical electrical ADJ bam-1807 47 7 stimulation stimulation NOUN bam-1807 47 8 , , PUNCT bam-1807 47 9 similar similar ADJ bam-1807 47 10 to to ADP bam-1807 47 11 the the DET bam-1807 47 12 electric electric ADJ bam-1807 47 13 firing firing NOUN bam-1807 47 14 of of ADP bam-1807 47 15 fast fast ADJ bam-1807 47 16 motoneurons motoneuron NOUN bam-1807 47 17 , , PUNCT bam-1807 47 18 can can AUX bam-1807 47 19 induce induce VERB bam-1807 47 20 a a DET bam-1807 47 21 slow slow ADJ bam-1807 47 22 - - PUNCT bam-1807 47 23 to to ADP bam-1807 47 24 - - PUNCT bam-1807 47 25 fast fast ADJ bam-1807 47 26 switch switch NOUN bam-1807 47 27 , , PUNCT bam-1807 47 28 whereas whereas SCONJ bam-1807 47 29 chronic chronic ADJ bam-1807 47 30 tonic tonic NOUN bam-1807 47 31 lowfrequency lowfrequency VERB bam-1807 47 32 electrical electrical ADJ bam-1807 47 33 stimulation stimulation NOUN bam-1807 47 34 , , PUNCT bam-1807 47 35 resembling resemble VERB bam-1807 47 36 the the DET bam-1807 47 37 firing firing NOUN bam-1807 47 38 pattern pattern NOUN bam-1807 47 39 of of ADP bam-1807 47 40 slow slow ADJ bam-1807 47 41 motoneurons motoneuron NOUN bam-1807 47 42 , , PUNCT bam-1807 47 43 can can AUX bam-1807 47 44 lead lead VERB bam-1807 47 45 to to ADP bam-1807 47 46 the the DET bam-1807 47 47 fast fast ADJ bam-1807 47 48 - - PUNCT bam-1807 47 49 toslow toslow NOUN bam-1807 47 50 switch switch NOUN bam-1807 47 51 , , PUNCT bam-1807 47 52 although although SCONJ bam-1807 47 53 , , PUNCT bam-1807 47 54 as as SCONJ bam-1807 47 55 pointed point VERB bam-1807 47 56 out out ADP bam-1807 47 57 by by ADP bam-1807 47 58 schiaffino schiaffino PROPN bam-1807 47 59 et et PROPN bam-1807 47 60 al al PROPN bam-1807 47 61 . . PUNCT bam-1807 48 1 [ [ X bam-1807 48 2 100 100 NUM bam-1807 48 3 ] ] PUNCT bam-1807 48 4 adaptations adaptation NOUN bam-1807 48 5 occur occur VERB bam-1807 48 6 within within ADP bam-1807 48 7 the the DET bam-1807 48 8 limits limit NOUN bam-1807 48 9 imposed impose VERB bam-1807 48 10 by by ADP bam-1807 48 11 intrinsic intrinsic ADJ bam-1807 48 12 differences difference NOUN bam-1807 48 13 between between ADP bam-1807 48 14 muscles muscle NOUN bam-1807 48 15 and and CCONJ bam-1807 48 16 fiber fiber NOUN bam-1807 48 17 types type NOUN bam-1807 48 18 . . PUNCT bam-1807 49 1 thus thus ADV bam-1807 49 2 , , PUNCT bam-1807 49 3 slow slow ADJ bam-1807 49 4 muscles muscle NOUN bam-1807 49 5 have have VERB bam-1807 49 6 the the DET bam-1807 49 7 capacity capacity NOUN bam-1807 49 8 to to PART bam-1807 49 9 adapt adapt VERB bam-1807 49 10 in in ADP bam-1807 49 11 the the DET bam-1807 49 12 range range NOUN bam-1807 49 13 i↔iia↔iix i↔iia↔iix NUM bam-1807 49 14 , , PUNCT bam-1807 49 15 and and CCONJ bam-1807 49 16 fast fast ADJ bam-1807 49 17 muscle muscle NOUN bam-1807 49 18 in in ADP bam-1807 49 19 the the DET bam-1807 49 20 range range NOUN bam-1807 49 21 iib↔iix↔iia iib↔iix↔iia NOUN bam-1807 49 22 . . PUNCT bam-1807 50 1 this this PRON bam-1807 50 2 equals equal VERB bam-1807 50 3 to to PART bam-1807 50 4 say say VERB bam-1807 50 5 that that SCONJ bam-1807 50 6 , , PUNCT bam-1807 50 7 grossly grossly ADV bam-1807 50 8 speaking speak VERB bam-1807 50 9 , , PUNCT bam-1807 50 10 strength strength NOUN bam-1807 50 11 training training NOUN bam-1807 50 12 favors favor VERB bam-1807 50 13 the the DET bam-1807 50 14 adaptation adaptation NOUN bam-1807 50 15 of of ADP bam-1807 50 16 muscles muscle NOUN bam-1807 50 17 to to ADP bam-1807 50 18 a a DET bam-1807 50 19 slow slow ADJ bam-1807 50 20 - - PUNCT bam-1807 50 21 to to ADP bam-1807 50 22 - - PUNCT bam-1807 50 23 fast fast ADJ bam-1807 50 24 switch switch NOUN bam-1807 50 25 , , PUNCT bam-1807 50 26 whereas whereas SCONJ bam-1807 50 27 endurance endurance NOUN bam-1807 50 28 the the DET bam-1807 50 29 exercised exercise VERB bam-1807 50 30 skeletal skeletal ADJ bam-1807 50 31 muscle muscle NOUN bam-1807 50 32 european european PROPN bam-1807 50 33 journal journal PROPN bam-1807 50 34 translational translational ADJ bam-1807 50 35 myology myology NOUN bam-1807 50 36 myology myology NOUN bam-1807 50 37 reviews review VERB bam-1807 50 38 20 20 NUM bam-1807 50 39 ( ( PUNCT bam-1807 50 40 3 3 NUM bam-1807 50 41 ): ): PUNCT bam-1807 50 42 105 105 NUM bam-1807 50 43 - - SYM bam-1807 50 44 120 120 NUM bam-1807 50 45 , , PUNCT bam-1807 50 46 2010 2010 NUM bam-1807 50 47 107 107 NUM bam-1807 50 48 exercises exercise VERB bam-1807 50 49 favor favor VERB bam-1807 50 50 the the DET bam-1807 50 51 fast fast ADJ bam-1807 50 52 - - PUNCT bam-1807 50 53 to to ADP bam-1807 50 54 - - PUNCT bam-1807 50 55 slow slow ADJ bam-1807 50 56 switch switch NOUN bam-1807 50 57 , , PUNCT bam-1807 50 58 although although SCONJ bam-1807 50 59 such such ADJ bam-1807 50 60 adaptations adaptation NOUN bam-1807 50 61 are be AUX bam-1807 50 62 usually usually ADV bam-1807 50 63 quantitatively quantitatively ADV bam-1807 50 64 less less ADJ bam-1807 50 65 than than ADP bam-1807 50 66 those those PRON bam-1807 50 67 induced induce VERB bam-1807 50 68 by by ADP bam-1807 50 69 chronic chronic ADJ bam-1807 50 70 electrical electrical ADJ bam-1807 50 71 stimulation stimulation NOUN bam-1807 50 72 [ [ X bam-1807 50 73 83 83 NUM bam-1807 50 74 ] ] PUNCT bam-1807 50 75 . . PUNCT bam-1807 51 1 as as ADP bam-1807 51 2 an an DET bam-1807 51 3 extreme extreme ADJ bam-1807 51 4 example example NOUN bam-1807 51 5 of of ADP bam-1807 51 6 adaptation adaptation NOUN bam-1807 51 7 , , PUNCT bam-1807 51 8 world world NOUN bam-1807 51 9 - - PUNCT bam-1807 51 10 class class NOUN bam-1807 51 11 marathon marathon NOUN bam-1807 51 12 runners runner NOUN bam-1807 51 13 and and CCONJ bam-1807 51 14 ultra ultra ADJ bam-1807 51 15 - - ADJ bam-1807 51 16 endurance endurance ADJ bam-1807 51 17 athletes athlete NOUN bam-1807 51 18 have have AUX bam-1807 51 19 been be AUX bam-1807 51 20 found find VERB bam-1807 51 21 to to PART bam-1807 51 22 express express VERB bam-1807 51 23 as as ADV bam-1807 51 24 much much ADJ bam-1807 51 25 as as ADP bam-1807 51 26 80 80 NUM bam-1807 51 27 - - SYM bam-1807 51 28 90 90 NUM bam-1807 51 29 % % NOUN bam-1807 51 30 of of ADP bam-1807 51 31 their their PRON bam-1807 51 32 mhc mhc PROPN bam-1807 51 33 pool pool NOUN bam-1807 51 34 as as ADP bam-1807 51 35 slow slow ADJ bam-1807 51 36 - - PUNCT bam-1807 51 37 type type NOUN bam-1807 51 38 mhc mhc PROPN bam-1807 51 39 ia ia PROPN bam-1807 51 40 , , PUNCT bam-1807 51 41 whereas whereas SCONJ bam-1807 51 42 in in ADP bam-1807 51 43 muscles muscle NOUN bam-1807 51 44 of of ADP bam-1807 51 45 elite elite ADJ bam-1807 51 46 sprinters sprinter NOUN bam-1807 51 47 and and CCONJ bam-1807 51 48 weightlifters weightlifter NOUN bam-1807 51 49 iia iia PROPN bam-1807 51 50 / / SYM bam-1807 51 51 iix iix PROPN bam-1807 51 52 fibers fiber NOUN bam-1807 51 53 largely largely ADV bam-1807 51 54 predominate predominate VERB bam-1807 51 55 [ [ X bam-1807 51 56 3 3 NUM bam-1807 51 57 ] ] PUNCT bam-1807 51 58 . . PUNCT bam-1807 52 1 although although SCONJ bam-1807 52 2 it it PRON bam-1807 52 3 has have AUX bam-1807 52 4 been be AUX bam-1807 52 5 suggested suggest VERB bam-1807 52 6 that that SCONJ bam-1807 52 7 such such ADJ bam-1807 52 8 pattern pattern NOUN bam-1807 52 9 of of ADP bam-1807 52 10 mhc mhc PROPN bam-1807 52 11 gene gene NOUN bam-1807 52 12 expression expression NOUN bam-1807 52 13 may may AUX bam-1807 52 14 be be AUX bam-1807 52 15 mainly mainly ADV bam-1807 52 16 ascribed ascribe VERB bam-1807 52 17 to to ADP bam-1807 52 18 the the DET bam-1807 52 19 genetic genetic ADJ bam-1807 52 20 predisposition predisposition NOUN bam-1807 52 21 of of ADP bam-1807 52 22 athletes athlete NOUN bam-1807 52 23 , , PUNCT bam-1807 52 24 it it PRON bam-1807 52 25 is be AUX bam-1807 52 26 common common ADJ bam-1807 52 27 opinion opinion NOUN bam-1807 52 28 that that SCONJ bam-1807 52 29 also also ADV bam-1807 52 30 the the DET bam-1807 52 31 specificity specificity NOUN bam-1807 52 32 of of ADP bam-1807 52 33 training training NOUN bam-1807 52 34 plays play VERB bam-1807 52 35 an an DET bam-1807 52 36 important important ADJ bam-1807 52 37 role role NOUN bam-1807 52 38 . . PUNCT bam-1807 53 1 activity activity NOUN bam-1807 53 2 - - PUNCT bam-1807 53 3 dependent dependent ADJ bam-1807 53 4 fiber fiber NOUN bam-1807 53 5 type type NOUN bam-1807 53 6 remodeling remodeling NOUN bam-1807 53 7 is be AUX bam-1807 53 8 mainly mainly ADV bam-1807 53 9 controlled control VERB bam-1807 53 10 by by ADP bam-1807 53 11 the the DET bam-1807 53 12 calcineurin calcineurin ADJ bam-1807 53 13 - - PUNCT bam-1807 53 14 nfat nfat NOUN bam-1807 53 15 pathway pathway NOUN bam-1807 53 16 that that PRON bam-1807 53 17 senses sense VERB bam-1807 53 18 the the DET bam-1807 53 19 ca2 ca2 PROPN bam-1807 53 20 + + PROPN bam-1807 53 21 content content NOUN bam-1807 53 22 of of ADP bam-1807 53 23 the the DET bam-1807 53 24 muscle muscle NOUN bam-1807 53 25 cell cell NOUN bam-1807 53 26 . . PUNCT bam-1807 54 1 calcineurin calcineurin PROPN bam-1807 54 2 is be AUX bam-1807 54 3 a a DET bam-1807 54 4 ca2+/calmodulin ca2+/calmodulin NOUN bam-1807 54 5 - - PUNCT bam-1807 54 6 dependent dependent ADJ bam-1807 54 7 protein protein NOUN bam-1807 54 8 phosphatase phosphatase NOUN bam-1807 54 9 that that PRON bam-1807 54 10 dephosphorylates dephosphorylate VERB bam-1807 54 11 the the DET bam-1807 54 12 transcription transcription NOUN bam-1807 54 13 factors factor NOUN bam-1807 54 14 of of ADP bam-1807 54 15 the the DET bam-1807 54 16 nfat nfat NOUN bam-1807 54 17 ( ( PUNCT bam-1807 54 18 nuclear nuclear ADJ bam-1807 54 19 factor factor NOUN bam-1807 54 20 of of ADP bam-1807 54 21 activated activate VERB bam-1807 54 22 t t NOUN bam-1807 54 23 cells cell NOUN bam-1807 54 24 ) ) PUNCT bam-1807 54 25 family family NOUN bam-1807 54 26 , , PUNCT bam-1807 54 27 inducing induce VERB bam-1807 54 28 their their PRON bam-1807 54 29 translocation translocation NOUN bam-1807 54 30 to to ADP bam-1807 54 31 the the DET bam-1807 54 32 nucleus nucleus NOUN bam-1807 54 33 and and CCONJ bam-1807 54 34 subsequent subsequent ADJ bam-1807 54 35 transcriptional transcriptional ADJ bam-1807 54 36 activation activation NOUN bam-1807 54 37 . . PUNCT bam-1807 55 1 several several ADJ bam-1807 55 2 lines line NOUN bam-1807 55 3 of of ADP bam-1807 55 4 evidence evidence NOUN bam-1807 55 5 suggest suggest VERB bam-1807 55 6 that that SCONJ bam-1807 55 7 calcineurin calcineurin PROPN bam-1807 55 8 is be AUX bam-1807 55 9 the the DET bam-1807 55 10 main main ADJ bam-1807 55 11 controller controller NOUN bam-1807 55 12 of of ADP bam-1807 55 13 the the DET bam-1807 55 14 activity activity NOUN bam-1807 55 15 - - PUNCT bam-1807 55 16 dependent dependent ADJ bam-1807 55 17 expression expression NOUN bam-1807 55 18 of of ADP bam-1807 55 19 the the DET bam-1807 55 20 slow slow ADJ bam-1807 55 21 mhc mhc PROPN bam-1807 55 22 gene gene NOUN bam-1807 55 23 program program NOUN bam-1807 55 24 in in ADP bam-1807 55 25 adult adult NOUN bam-1807 55 26 muscles muscle NOUN bam-1807 55 27 ( ( PUNCT bam-1807 55 28 reviewed review VERB bam-1807 55 29 by by ADP bam-1807 55 30 [ [ X bam-1807 55 31 100 100 NUM bam-1807 55 32 ] ] PUNCT bam-1807 55 33 ) ) PUNCT bam-1807 55 34 , , PUNCT bam-1807 55 35 whereas whereas SCONJ bam-1807 55 36 fiber fiber NOUN bam-1807 55 37 metabolic metabolic NOUN bam-1807 55 38 adaptation adaptation NOUN bam-1807 55 39 and and CCONJ bam-1807 55 40 other other ADJ bam-1807 55 41 activitydependent activitydependent ADJ bam-1807 55 42 changes change NOUN bam-1807 55 43 are be AUX bam-1807 55 44 likely likely ADJ bam-1807 55 45 to to PART bam-1807 55 46 be be AUX bam-1807 55 47 independent independent ADJ bam-1807 55 48 of of ADP bam-1807 55 49 the the DET bam-1807 55 50 calcineurin calcineurin ADJ bam-1807 55 51 pathway pathway NOUN bam-1807 55 52 . . PUNCT bam-1807 56 1 3 3 X bam-1807 56 2 . . X bam-1807 56 3 exercise exercise NOUN bam-1807 56 4 - - PUNCT bam-1807 56 5 induced induce VERB bam-1807 56 6 muscle muscle NOUN bam-1807 56 7 hypertrophy hypertrophy NOUN bam-1807 56 8 exercise exercise NOUN bam-1807 56 9 - - PUNCT bam-1807 56 10 induced induce VERB bam-1807 56 11 muscle muscle NOUN bam-1807 56 12 hypertrophy hypertrophy NOUN bam-1807 56 13 is be AUX bam-1807 56 14 observed observe VERB bam-1807 56 15 mostly mostly ADV bam-1807 56 16 as as ADP bam-1807 56 17 a a DET bam-1807 56 18 consequence consequence NOUN bam-1807 56 19 of of ADP bam-1807 56 20 resistance resistance NOUN bam-1807 56 21 training training NOUN bam-1807 56 22 . . PUNCT bam-1807 57 1 progressive progressive ADJ bam-1807 57 2 high high ADJ bam-1807 57 3 - - PUNCT bam-1807 57 4 resistance resistance NOUN bam-1807 57 5 exercise exercise NOUN bam-1807 57 6 leads lead VERB bam-1807 57 7 to to ADP bam-1807 57 8 muscle muscle NOUN bam-1807 57 9 fiber fiber NOUN bam-1807 57 10 hypertrophy hypertrophy NOUN bam-1807 57 11 by by ADP bam-1807 57 12 two two NUM bam-1807 57 13 partially partially ADV bam-1807 57 14 independent independent ADJ bam-1807 57 15 mechanisms mechanism NOUN bam-1807 57 16 , , PUNCT bam-1807 57 17 the the DET bam-1807 57 18 induction induction NOUN bam-1807 57 19 of of ADP bam-1807 57 20 satellite satellite NOUN bam-1807 57 21 cell cell NOUN bam-1807 57 22 activation activation NOUN bam-1807 57 23 and and CCONJ bam-1807 57 24 recruitment recruitment NOUN bam-1807 57 25 and and CCONJ bam-1807 57 26 the the DET bam-1807 57 27 increase increase NOUN bam-1807 57 28 of of ADP bam-1807 57 29 muscle muscle NOUN bam-1807 57 30 protein protein NOUN bam-1807 57 31 synthesis synthesis NOUN bam-1807 57 32 . . PUNCT bam-1807 58 1 a a DET bam-1807 58 2 number number NOUN bam-1807 58 3 of of ADP bam-1807 58 4 signal signal ADJ bam-1807 58 5 transduction transduction NOUN bam-1807 58 6 pathways pathway NOUN bam-1807 58 7 results result NOUN bam-1807 58 8 into into ADP bam-1807 58 9 the the DET bam-1807 58 10 stimulation stimulation NOUN bam-1807 58 11 of of ADP bam-1807 58 12 the the DET bam-1807 58 13 mtor mtor NOUN bam-1807 58 14 ( ( PUNCT bam-1807 58 15 mammalian mammalian ADJ bam-1807 58 16 target target NOUN bam-1807 58 17 of of ADP bam-1807 58 18 rapamycin rapamycin NOUN bam-1807 58 19 ) ) PUNCT bam-1807 58 20 system system NOUN bam-1807 58 21 , , PUNCT bam-1807 58 22 which which PRON bam-1807 58 23 mainly mainly ADV bam-1807 58 24 acts act VERB bam-1807 58 25 by by ADP bam-1807 58 26 upregulating upregulating ADJ bam-1807 58 27 protein protein NOUN bam-1807 58 28 synthesis synthesis NOUN bam-1807 58 29 . . PUNCT bam-1807 59 1 the the DET bam-1807 59 2 mtor mtor PROPN bam-1807 59 3 system system NOUN bam-1807 59 4 is be AUX bam-1807 59 5 controlled control VERB bam-1807 59 6 by by ADP bam-1807 59 7 hormones hormone NOUN bam-1807 59 8 and and CCONJ bam-1807 59 9 growth growth NOUN bam-1807 59 10 factors factor NOUN bam-1807 59 11 , , PUNCT bam-1807 59 12 catecholamines catecholamine NOUN bam-1807 59 13 , , PUNCT bam-1807 59 14 mechanotransduction mechanotransduction NOUN bam-1807 59 15 signals signal NOUN bam-1807 59 16 , , PUNCT bam-1807 59 17 phosphatidic phosphatidic ADJ bam-1807 59 18 acid acid NOUN bam-1807 59 19 , , PUNCT bam-1807 59 20 amino amino ADJ bam-1807 59 21 acids acid NOUN bam-1807 59 22 and and CCONJ bam-1807 59 23 the the DET bam-1807 59 24 energetic energetic ADJ bam-1807 59 25 state state NOUN bam-1807 59 26 of of ADP bam-1807 59 27 the the DET bam-1807 59 28 muscle muscle NOUN bam-1807 59 29 [ [ X bam-1807 59 30 118 118 NUM bam-1807 59 31 ] ] PUNCT bam-1807 59 32 . . PUNCT bam-1807 60 1 at at ADV bam-1807 60 2 least least ADV bam-1807 60 3 two two NUM bam-1807 60 4 systems system NOUN bam-1807 60 5 oppose oppose VERB bam-1807 60 6 such such ADJ bam-1807 60 7 hypertrophy hypertrophy NOUN bam-1807 60 8 pathway pathway NOUN bam-1807 60 9 , , PUNCT bam-1807 60 10 the the DET bam-1807 60 11 myostatin myostatin NOUN bam-1807 60 12 - - PUNCT bam-1807 60 13 smad smad ADJ bam-1807 60 14 signalling signalling NOUN bam-1807 60 15 , , PUNCT bam-1807 60 16 which which PRON bam-1807 60 17 inhibits inhibit VERB bam-1807 60 18 muscle muscle NOUN bam-1807 60 19 growth growth NOUN bam-1807 60 20 via via ADP bam-1807 60 21 gene gene NOUN bam-1807 60 22 transcription transcription NOUN bam-1807 60 23 and and CCONJ bam-1807 60 24 is be AUX bam-1807 60 25 in in ADP bam-1807 60 26 turn turn NOUN bam-1807 60 27 controlled control VERB bam-1807 60 28 by by ADP bam-1807 60 29 caveolin-3 caveolin-3 PROPN bam-1807 60 30 [ [ X bam-1807 60 31 79 79 NUM bam-1807 60 32 ] ] PUNCT bam-1807 60 33 , , PUNCT bam-1807 60 34 and and CCONJ bam-1807 60 35 the the DET bam-1807 60 36 atrophy atrophy NOUN bam-1807 60 37 - - PUNCT bam-1807 60 38 related relate VERB bam-1807 60 39 pathways pathway NOUN bam-1807 60 40 [ [ X bam-1807 60 41 98 98 NUM bam-1807 60 42 ] ] PUNCT bam-1807 60 43 . . PUNCT bam-1807 61 1 mtor mtor PROPN bam-1807 61 2 is be AUX bam-1807 61 3 a a DET bam-1807 61 4 conserved conserved ADJ bam-1807 61 5 ser ser NOUN bam-1807 61 6 / / SYM bam-1807 61 7 thr thr PROPN bam-1807 61 8 kinase kinase NOUN bam-1807 61 9 of of ADP bam-1807 61 10 the the DET bam-1807 61 11 phosphatidylinositol phosphatidylinositol NOUN bam-1807 61 12 kinase kinase NOUN bam-1807 61 13 - - PUNCT bam-1807 61 14 related relate VERB bam-1807 61 15 kinase kinase NOUN bam-1807 61 16 family family NOUN bam-1807 61 17 . . PUNCT bam-1807 62 1 it it PRON bam-1807 62 2 plays play VERB bam-1807 62 3 a a DET bam-1807 62 4 key key ADJ bam-1807 62 5 role role NOUN bam-1807 62 6 in in ADP bam-1807 62 7 the the DET bam-1807 62 8 coordination coordination NOUN bam-1807 62 9 of of ADP bam-1807 62 10 important important ADJ bam-1807 62 11 mechanisms mechanism NOUN bam-1807 62 12 such such ADJ bam-1807 62 13 as as ADP bam-1807 62 14 metabolism metabolism NOUN bam-1807 62 15 and and CCONJ bam-1807 62 16 cell cell NOUN bam-1807 62 17 growth growth NOUN bam-1807 62 18 [ [ X bam-1807 62 19 121 121 NUM bam-1807 62 20 ] ] PUNCT bam-1807 62 21 . . PUNCT bam-1807 63 1 in in ADP bam-1807 63 2 mammals mammal NOUN bam-1807 63 3 , , PUNCT bam-1807 63 4 mtor mtor PROPN bam-1807 63 5 exists exist VERB bam-1807 63 6 in in ADP bam-1807 63 7 two two NUM bam-1807 63 8 distinct distinct ADJ bam-1807 63 9 multiprotein multiprotein ADJ bam-1807 63 10 complexes complex NOUN bam-1807 63 11 , , PUNCT bam-1807 63 12 torc1 torc1 NOUN bam-1807 63 13 and and CCONJ bam-1807 63 14 torc2 torc2 PROPN bam-1807 63 15 . . PUNCT bam-1807 64 1 torc1 torc1 PROPN bam-1807 64 2 is be AUX bam-1807 64 3 a a DET bam-1807 64 4 complex complex NOUN bam-1807 64 5 comprised comprise VERB bam-1807 64 6 of of ADP bam-1807 64 7 mtor mtor NOUN bam-1807 64 8 , , PUNCT bam-1807 64 9 regulatory regulatory ADJ bam-1807 64 10 associated associate VERB bam-1807 64 11 protein protein NOUN bam-1807 64 12 of of ADP bam-1807 64 13 mtor mtor NOUN bam-1807 64 14 ( ( PUNCT bam-1807 64 15 raptor raptor NOUN bam-1807 64 16 ) ) PUNCT bam-1807 64 17 , , PUNCT bam-1807 64 18 and and CCONJ bam-1807 64 19 g g ADP bam-1807 64 20 protein protein NOUN bam-1807 64 21 -subunit -subunit VERB bam-1807 64 22 - - PUNCT bam-1807 64 23 like like ADJ bam-1807 64 24 gl gl NOUN bam-1807 64 25 or or CCONJ bam-1807 64 26 mlst8 mlst8 PROPN bam-1807 64 27 . . PUNCT bam-1807 65 1 the the DET bam-1807 65 2 torc2 torc2 PROPN bam-1807 65 3 complex complex NOUN bam-1807 65 4 is be AUX bam-1807 65 5 comprised comprise VERB bam-1807 65 6 of of ADP bam-1807 65 7 mtor mtor NOUN bam-1807 65 8 , , PUNCT bam-1807 65 9 rapamycin rapamycin NOUN bam-1807 65 10 - - PUNCT bam-1807 65 11 insensitive insensitive ADJ bam-1807 65 12 companion companion NOUN bam-1807 65 13 of of ADP bam-1807 65 14 mtor mtor NOUN bam-1807 65 15 ( ( PUNCT bam-1807 65 16 rictor rictor NOUN bam-1807 65 17 ) ) PUNCT bam-1807 65 18 , , PUNCT bam-1807 65 19 stress stress NOUN bam-1807 65 20 - - PUNCT bam-1807 65 21 activated activate VERB bam-1807 65 22 - - PUNCT bam-1807 65 23 protein protein NOUN bam-1807 65 24 - - PUNCT bam-1807 65 25 kinase kinase NOUN bam-1807 65 26 - - PUNCT bam-1807 65 27 interacting interact VERB bam-1807 65 28 protein protein NOUN bam-1807 65 29 1 1 NUM bam-1807 65 30 ( ( PUNCT bam-1807 65 31 sin1 sin1 PROPN bam-1807 65 32 ) ) PUNCT bam-1807 65 33 , , PUNCT bam-1807 65 34 and and CCONJ bam-1807 65 35 g g PROPN bam-1807 65 36 l. l. PROPN bam-1807 65 37 only only ADV bam-1807 65 38 the the DET bam-1807 65 39 former former ADJ bam-1807 65 40 complex complex NOUN bam-1807 65 41 is be AUX bam-1807 65 42 controlled control VERB bam-1807 65 43 by by ADP bam-1807 65 44 exercise exercise NOUN bam-1807 65 45 and and CCONJ bam-1807 65 46 energy energy NOUN bam-1807 65 47 - - PUNCT bam-1807 65 48 related relate VERB bam-1807 65 49 signals signal NOUN bam-1807 65 50 , , PUNCT bam-1807 65 51 and and CCONJ bam-1807 65 52 is be AUX bam-1807 65 53 involved involve VERB bam-1807 65 54 in in ADP bam-1807 65 55 the the DET bam-1807 65 56 regulation regulation NOUN bam-1807 65 57 of of ADP bam-1807 65 58 cell cell NOUN bam-1807 65 59 growth growth NOUN bam-1807 65 60 and and CCONJ bam-1807 65 61 metabolism metabolism NOUN bam-1807 65 62 , , PUNCT bam-1807 65 63 which which PRON bam-1807 65 64 , , PUNCT bam-1807 65 65 in in ADP bam-1807 65 66 the the DET bam-1807 65 67 exercised exercised ADJ bam-1807 65 68 muscle muscle NOUN bam-1807 65 69 , , PUNCT bam-1807 65 70 result result VERB bam-1807 65 71 in in ADP bam-1807 65 72 fiber fiber NOUN bam-1807 65 73 enlargement enlargement NOUN bam-1807 66 1 [ [ X bam-1807 66 2 74 74 NUM bam-1807 66 3 ] ] PUNCT bam-1807 66 4 . . PUNCT bam-1807 67 1 the the DET bam-1807 67 2 best well ADV bam-1807 67 3 understood understand VERB bam-1807 67 4 targets target NOUN bam-1807 67 5 of of ADP bam-1807 67 6 mtor mtor NOUN bam-1807 67 7 are be AUX bam-1807 67 8 the the DET bam-1807 67 9 translation translation NOUN bam-1807 67 10 regulators regulator NOUN bam-1807 67 11 70 70 NUM bam-1807 67 12 - - PUNCT bam-1807 67 13 kda kda NOUN bam-1807 67 14 ribosomal ribosomal NOUN bam-1807 67 15 protein protein NOUN bam-1807 67 16 s6 s6 PROPN bam-1807 67 17 kinase kinase PROPN bam-1807 67 18 ( ( PUNCT bam-1807 67 19 p70s6k p70s6k PROPN bam-1807 67 20 ) ) PUNCT bam-1807 67 21 s6k1 s6k1 NOUN bam-1807 67 22 and and CCONJ bam-1807 67 23 4e 4e PROPN bam-1807 67 24 - - PUNCT bam-1807 67 25 bp1 bp1 PROPN bam-1807 67 26 . . PUNCT bam-1807 68 1 however however ADV bam-1807 68 2 , , PUNCT bam-1807 68 3 it it PRON bam-1807 68 4 is be AUX bam-1807 68 5 important important ADJ bam-1807 68 6 to to PART bam-1807 68 7 stress stress VERB bam-1807 68 8 that that SCONJ bam-1807 68 9 mtor mtor PROPN bam-1807 68 10 controls control VERB bam-1807 68 11 several several ADJ bam-1807 68 12 additional additional ADJ bam-1807 68 13 growth growth NOUN bam-1807 68 14 - - PUNCT bam-1807 68 15 related relate VERB bam-1807 68 16 processes process NOUN bam-1807 68 17 and and CCONJ bam-1807 68 18 inhibits inhibit VERB bam-1807 68 19 apoptotic apoptotic ADJ bam-1807 68 20 signaling signaling NOUN bam-1807 68 21 . . PUNCT bam-1807 69 1 it it PRON bam-1807 69 2 should should AUX bam-1807 69 3 be be AUX bam-1807 69 4 also also ADV bam-1807 69 5 emphasized emphasize VERB bam-1807 69 6 that that SCONJ bam-1807 69 7 tor tor NOUN bam-1807 69 8 has have VERB bam-1807 69 9 different different ADJ bam-1807 69 10 functions function NOUN bam-1807 69 11 in in ADP bam-1807 69 12 different different ADJ bam-1807 69 13 tissues tissue NOUN bam-1807 69 14 , , PUNCT bam-1807 69 15 and and CCONJ bam-1807 69 16 pharmacological pharmacological ADJ bam-1807 69 17 inhibition inhibition NOUN bam-1807 69 18 of of ADP bam-1807 69 19 the the DET bam-1807 69 20 torc1 torc1 PROPN bam-1807 69 21 complex complex NOUN bam-1807 69 22 may may AUX bam-1807 69 23 be be AUX bam-1807 69 24 beneficial beneficial ADJ bam-1807 69 25 in in ADP bam-1807 69 26 some some DET bam-1807 69 27 tissues tissue NOUN bam-1807 69 28 and and CCONJ bam-1807 69 29 detrimental detrimental ADJ bam-1807 69 30 in in ADP bam-1807 69 31 others other NOUN bam-1807 70 1 [ [ X bam-1807 70 2 109 109 NUM bam-1807 70 3 ] ] PUNCT bam-1807 70 4 . . PUNCT bam-1807 71 1 among among ADP bam-1807 71 2 the the DET bam-1807 71 3 growth growth NOUN bam-1807 71 4 promoting promote VERB bam-1807 71 5 factors factor NOUN bam-1807 71 6 regulating regulate VERB bam-1807 71 7 mtor mtor NOUN bam-1807 71 8 , , PUNCT bam-1807 71 9 igf-1 igf-1 NOUN bam-1807 71 10 ( ( PUNCT bam-1807 71 11 insulin insulin NOUN bam-1807 71 12 - - PUNCT bam-1807 71 13 like like ADJ bam-1807 71 14 growth growth NOUN bam-1807 71 15 factor-1 factor-1 NUM bam-1807 71 16 ) ) PUNCT bam-1807 71 17 is be AUX bam-1807 71 18 the the DET bam-1807 71 19 best good ADJ bam-1807 71 20 characterized characterize VERB bam-1807 71 21 one one NUM bam-1807 71 22 . . PUNCT bam-1807 72 1 circulating circulate VERB bam-1807 72 2 igf-1 igf-1 NOUN bam-1807 72 3 is be AUX bam-1807 72 4 produced produce VERB bam-1807 72 5 mainly mainly ADV bam-1807 72 6 by by ADP bam-1807 72 7 the the DET bam-1807 72 8 liver liver NOUN bam-1807 72 9 under under ADP bam-1807 72 10 growth growth NOUN bam-1807 72 11 hormone hormone NOUN bam-1807 72 12 control control NOUN bam-1807 72 13 , , PUNCT bam-1807 72 14 however however ADV bam-1807 72 15 stretch stretch VERB bam-1807 72 16 and and CCONJ bam-1807 72 17 overload overload NOUN bam-1807 72 18 induce induce VERB bam-1807 72 19 skeletal skeletal ADJ bam-1807 72 20 muscle muscle NOUN bam-1807 72 21 to to PART bam-1807 72 22 synthesize synthesize VERB bam-1807 72 23 much much ADJ bam-1807 72 24 of of ADP bam-1807 72 25 the the DET bam-1807 72 26 circulating circulate VERB bam-1807 72 27 igf-1 igf-1 NOUN bam-1807 72 28 , , PUNCT bam-1807 72 29 and and CCONJ bam-1807 72 30 also also ADV bam-1807 72 31 to to PART bam-1807 72 32 utilize utilize VERB bam-1807 72 33 most most ADJ bam-1807 72 34 of of ADP bam-1807 72 35 it it PRON bam-1807 72 36 . . PUNCT bam-1807 73 1 as as ADV bam-1807 73 2 far far ADV bam-1807 73 3 as as SCONJ bam-1807 73 4 increase increase NOUN bam-1807 73 5 in in ADP bam-1807 73 6 mass mass NOUN bam-1807 73 7 is be AUX bam-1807 73 8 concerned concern VERB bam-1807 73 9 , , PUNCT bam-1807 73 10 golspink golspink NOUN bam-1807 73 11 's 's PART bam-1807 73 12 group group NOUN bam-1807 73 13 [ [ X bam-1807 73 14 33 33 NUM bam-1807 73 15 ] ] PUNCT bam-1807 73 16 cloned clone VERB bam-1807 73 17 three three NUM bam-1807 73 18 splice splice NOUN bam-1807 73 19 variant variant NOUN bam-1807 73 20 of of ADP bam-1807 73 21 igf-1 igf-1 ADV bam-1807 73 22 produced produce VERB bam-1807 73 23 in in ADP bam-1807 73 24 human human ADJ bam-1807 73 25 muscle muscle NOUN bam-1807 73 26 ; ; PUNCT bam-1807 73 27 one one NUM bam-1807 73 28 of of ADP bam-1807 73 29 these these PRON bam-1807 73 30 , , PUNCT bam-1807 73 31 which which PRON bam-1807 73 32 was be AUX bam-1807 73 33 called call VERB bam-1807 73 34 mechano mechano PROPN bam-1807 73 35 growth growth NOUN bam-1807 73 36 factor factor NOUN bam-1807 73 37 ( ( PUNCT bam-1807 73 38 mgf mgf PROPN bam-1807 73 39 ) ) PUNCT bam-1807 73 40 to to PART bam-1807 73 41 distinguish distinguish VERB bam-1807 73 42 it it PRON bam-1807 73 43 from from ADP bam-1807 73 44 the the DET bam-1807 73 45 other other ADJ bam-1807 73 46 igfs igf NOUN bam-1807 73 47 which which PRON bam-1807 73 48 have have VERB bam-1807 73 49 a a DET bam-1807 73 50 systemic systemic ADJ bam-1807 73 51 mode mode NOUN bam-1807 73 52 of of ADP bam-1807 73 53 action action NOUN bam-1807 73 54 , , PUNCT bam-1807 73 55 is be AUX bam-1807 73 56 produced produce VERB bam-1807 73 57 only only ADV bam-1807 73 58 by by ADP bam-1807 73 59 active active ADJ bam-1807 73 60 muscle muscle NOUN bam-1807 73 61 and and CCONJ bam-1807 73 62 appears appear VERB bam-1807 73 63 to to PART bam-1807 73 64 be be AUX bam-1807 73 65 the the DET bam-1807 73 66 factor factor NOUN bam-1807 73 67 that that PRON bam-1807 73 68 controls control VERB bam-1807 73 69 local local ADJ bam-1807 73 70 tissue tissue NOUN bam-1807 73 71 repair repair NOUN bam-1807 73 72 , , PUNCT bam-1807 73 73 maintenance maintenance NOUN bam-1807 73 74 and and CCONJ bam-1807 73 75 remodeling remodeling NOUN bam-1807 73 76 by by ADP bam-1807 73 77 an an DET bam-1807 73 78 autocrine autocrine NOUN bam-1807 73 79 / / SYM bam-1807 73 80 paracrine paracrine NOUN bam-1807 73 81 mechanism mechanism NOUN bam-1807 73 82 . . PUNCT bam-1807 74 1 notably notably ADV bam-1807 74 2 , , PUNCT bam-1807 74 3 dystrophic dystrophic ADJ bam-1807 74 4 muscle muscle NOUN bam-1807 74 5 , , PUNCT bam-1807 74 6 unlike unlike ADP bam-1807 74 7 normal normal ADJ bam-1807 74 8 muscle muscle NOUN bam-1807 74 9 , , PUNCT bam-1807 74 10 is be AUX bam-1807 74 11 unable unable ADJ bam-1807 74 12 to to PART bam-1807 74 13 express express VERB bam-1807 74 14 mgf mgf NOUN bam-1807 74 15 in in ADP bam-1807 74 16 response response NOUN bam-1807 74 17 to to PART bam-1807 74 18 overload overload VERB bam-1807 74 19 . . PUNCT bam-1807 75 1 moreover moreover ADV bam-1807 75 2 , , PUNCT bam-1807 75 3 the the DET bam-1807 75 4 ability ability NOUN bam-1807 75 5 to to PART bam-1807 75 6 express express VERB bam-1807 75 7 mgf mgf PROPN bam-1807 75 8 has have AUX bam-1807 75 9 been be AUX bam-1807 75 10 found find VERB bam-1807 75 11 to to PART bam-1807 75 12 decline decline VERB bam-1807 75 13 markedly markedly ADV bam-1807 75 14 during during ADP bam-1807 75 15 ageing age VERB bam-1807 75 16 [ [ X bam-1807 75 17 33 33 NUM bam-1807 75 18 ] ] PUNCT bam-1807 75 19 . . PUNCT bam-1807 76 1 mgf mgf PROPN bam-1807 76 2 was be AUX bam-1807 76 3 also also ADV bam-1807 76 4 found find VERB bam-1807 76 5 to to PART bam-1807 76 6 directly directly ADV bam-1807 76 7 activate activate VERB bam-1807 76 8 the the DET bam-1807 76 9 satellite satellite NOUN bam-1807 76 10 cell cell NOUN bam-1807 76 11 pool pool NOUN bam-1807 76 12 and and CCONJ bam-1807 76 13 to to PART bam-1807 76 14 replenish replenish VERB bam-1807 76 15 it it PRON bam-1807 76 16 after after ADP bam-1807 76 17 damage damage NOUN bam-1807 76 18 [ [ X bam-1807 76 19 38 38 NUM bam-1807 76 20 ] ] PUNCT bam-1807 76 21 . . PUNCT bam-1807 77 1 on on ADP bam-1807 77 2 the the DET bam-1807 77 3 other other ADJ bam-1807 77 4 hand hand NOUN bam-1807 77 5 , , PUNCT bam-1807 77 6 both both PRON bam-1807 77 7 insulin insulin NOUN bam-1807 77 8 and and CCONJ bam-1807 77 9 the the DET bam-1807 77 10 systemic systemic ADJ bam-1807 77 11 igf-1 igf-1 NOUN bam-1807 77 12 isoforms isoform NOUN bam-1807 77 13 , , PUNCT bam-1807 77 14 produced produce VERB bam-1807 77 15 also also ADV bam-1807 77 16 by by ADP bam-1807 77 17 active active ADJ bam-1807 77 18 muscle muscle NOUN bam-1807 77 19 , , PUNCT bam-1807 77 20 are be AUX bam-1807 77 21 involved involve VERB bam-1807 77 22 in in ADP bam-1807 77 23 mtor mtor NOUN bam-1807 77 24 activation activation NOUN bam-1807 77 25 , , PUNCT bam-1807 77 26 which which PRON bam-1807 77 27 in in ADP bam-1807 77 28 turn turn NOUN bam-1807 77 29 leads lead VERB bam-1807 77 30 to to ADP bam-1807 77 31 the the DET bam-1807 77 32 upregulation upregulation NOUN bam-1807 77 33 of of ADP bam-1807 77 34 protein protein NOUN bam-1807 77 35 synthesis synthesis NOUN bam-1807 77 36 in in ADP bam-1807 77 37 active active ADJ bam-1807 77 38 muscle muscle NOUN bam-1807 77 39 [ [ X bam-1807 77 40 115 115 NUM bam-1807 77 41 ] ] PUNCT bam-1807 77 42 . . PUNCT bam-1807 78 1 both both DET bam-1807 78 2 insulin insulin NOUN bam-1807 78 3 and and CCONJ bam-1807 78 4 igf-1 igf-1 NOUN bam-1807 78 5 activate activate VERB bam-1807 78 6 pi3k pi3k PROPN bam-1807 78 7 , , PUNCT bam-1807 78 8 which which PRON bam-1807 78 9 generates generate VERB bam-1807 78 10 phosphatidylinositol-3,4,5 phosphatidylinositol-3,4,5 NOUN bam-1807 78 11 - - NOUN bam-1807 78 12 triphosphate triphosphate NOUN bam-1807 78 13 ( ( PUNCT bam-1807 78 14 pip3 pip3 NOUN bam-1807 78 15 ) ) PUNCT bam-1807 78 16 . . PUNCT bam-1807 79 1 in in ADP bam-1807 79 2 turn turn NOUN bam-1807 79 3 , , PUNCT bam-1807 79 4 pip3 pip3 NOUN bam-1807 79 5 recruits recruit VERB bam-1807 79 6 akt akt PROPN bam-1807 79 7 / / SYM bam-1807 79 8 pkb pkb PROPN bam-1807 79 9 to to ADP bam-1807 79 10 the the DET bam-1807 79 11 plasma plasma NOUN bam-1807 79 12 membrane membrane NOUN bam-1807 79 13 , , PUNCT bam-1807 79 14 where where SCONJ bam-1807 79 15 it it PRON bam-1807 79 16 is be AUX bam-1807 79 17 phosphorylated phosphorylate VERB bam-1807 79 18 by by ADP bam-1807 79 19 at at ADV bam-1807 79 20 least least ADV bam-1807 79 21 two two NUM bam-1807 79 22 distinct distinct ADJ bam-1807 79 23 kinases kinase NOUN bam-1807 79 24 , , PUNCT bam-1807 79 25 pdk1 pdk1 PROPN bam-1807 79 26 and and CCONJ bam-1807 79 27 the the DET bam-1807 79 28 torc2 torc2 PROPN bam-1807 79 29 complex complex NOUN bam-1807 79 30 . . PUNCT bam-1807 80 1 of of ADP bam-1807 80 2 the the DET bam-1807 80 3 three three NUM bam-1807 80 4 isoforms isoform NOUN bam-1807 80 5 present present ADJ bam-1807 80 6 in in ADP bam-1807 80 7 mammals mammal NOUN bam-1807 80 8 , , PUNCT bam-1807 80 9 exercise exercise NOUN bam-1807 80 10 is be AUX bam-1807 80 11 associated associate VERB bam-1807 80 12 with with ADP bam-1807 80 13 the the DET bam-1807 80 14 activation activation NOUN bam-1807 80 15 of of ADP bam-1807 80 16 akt1 akt1 NOUN bam-1807 80 17 ( ( PUNCT bam-1807 80 18 pkbα pkbα NOUN bam-1807 80 19 ) ) PUNCT bam-1807 80 20 , , PUNCT bam-1807 80 21 which which PRON bam-1807 80 22 is be AUX bam-1807 80 23 upregulated upregulate VERB bam-1807 80 24 by by ADP bam-1807 80 25 igf1 igf1 PROPN bam-1807 80 26 and and CCONJ bam-1807 80 27 by by ADP bam-1807 80 28 still still ADV bam-1807 80 29 unidentified unidentified ADJ bam-1807 80 30 contraction contraction NOUN bam-1807 80 31 signals signal NOUN bam-1807 80 32 , , PUNCT bam-1807 80 33 whereas whereas SCONJ bam-1807 80 34 insulin insulin NOUN bam-1807 80 35 is be AUX bam-1807 80 36 known know VERB bam-1807 80 37 to to PART bam-1807 80 38 activate activate VERB bam-1807 80 39 akt2 akt2 PROPN bam-1807 80 40 . . PUNCT bam-1807 81 1 akt akt PROPN bam-1807 81 2 upregulates upregulate VERB bam-1807 81 3 protein protein NOUN bam-1807 81 4 synthesis synthesis NOUN bam-1807 81 5 by by ADP bam-1807 81 6 activating activate VERB bam-1807 81 7 the the DET bam-1807 81 8 torc1 torc1 PROPN bam-1807 81 9 pathway pathway NOUN bam-1807 81 10 and and CCONJ bam-1807 81 11 by by ADP bam-1807 81 12 inhibiting inhibit VERB bam-1807 81 13 glycogen glycogen NOUN bam-1807 81 14 synthase synthase NOUN bam-1807 81 15 kinase kinase PROPN bam-1807 81 16 3β 3β NUM bam-1807 81 17 ( ( PUNCT bam-1807 81 18 gsk3β gsk3β PROPN bam-1807 81 19 ) ) PUNCT bam-1807 81 20 . . PUNCT bam-1807 82 1 the the DET bam-1807 82 2 latter latter ADJ bam-1807 82 3 enzyme enzyme NOUN bam-1807 82 4 downregulates downregulate VERB bam-1807 82 5 protein protein NOUN bam-1807 82 6 synthesis synthesis NOUN bam-1807 82 7 via via ADP bam-1807 82 8 eif2b eif2b PROPN bam-1807 82 9 ( ( PUNCT bam-1807 82 10 eukaryotic eukaryotic ADJ bam-1807 82 11 initiation initiation NOUN bam-1807 82 12 factor factor NOUN bam-1807 82 13 2b 2b NOUN bam-1807 82 14 ) ) PUNCT bam-1807 82 15 inhibition inhibition NOUN bam-1807 82 16 , , PUNCT bam-1807 82 17 so so SCONJ bam-1807 82 18 that that SCONJ bam-1807 82 19 akt akt PROPN bam-1807 82 20 acts act VERB bam-1807 82 21 by by ADP bam-1807 82 22 relieving relieve VERB bam-1807 82 23 such such ADJ bam-1807 82 24 downregulation downregulation NOUN bam-1807 82 25 . . PUNCT bam-1807 83 1 moreover moreover ADV bam-1807 83 2 , , PUNCT bam-1807 83 3 akt akt PROPN bam-1807 83 4 inhibits inhibit VERB bam-1807 83 5 the the DET bam-1807 83 6 foxo foxo ADJ bam-1807 83 7 pathway pathway NOUN bam-1807 83 8 , , PUNCT bam-1807 83 9 which which PRON bam-1807 83 10 controls control VERB bam-1807 83 11 protein protein NOUN bam-1807 83 12 degradation degradation NOUN bam-1807 83 13 [ [ X bam-1807 83 14 98 98 NUM bam-1807 83 15 ] ] PUNCT bam-1807 83 16 . . PUNCT bam-1807 84 1 the the DET bam-1807 84 2 exercised exercise VERB bam-1807 84 3 skeletal skeletal ADJ bam-1807 84 4 muscle muscle NOUN bam-1807 84 5 european european PROPN bam-1807 84 6 journal journal PROPN bam-1807 84 7 translational translational ADJ bam-1807 84 8 myology myology NOUN bam-1807 84 9 myology myology NOUN bam-1807 84 10 reviews review VERB bam-1807 84 11 20 20 NUM bam-1807 84 12 ( ( PUNCT bam-1807 84 13 3 3 NUM bam-1807 84 14 ): ): PUNCT bam-1807 84 15 105 105 NUM bam-1807 84 16 - - SYM bam-1807 84 17 120 120 NUM bam-1807 84 18 , , PUNCT bam-1807 84 19 2010 2010 NUM bam-1807 84 20 108 108 NUM bam-1807 84 21 the the DET bam-1807 84 22 exercise exercise NOUN bam-1807 84 23 - - PUNCT bam-1807 84 24 induced induce VERB bam-1807 84 25 increase increase NOUN bam-1807 84 26 in in ADP bam-1807 84 27 catecholamines catecholamine NOUN bam-1807 84 28 may may AUX bam-1807 84 29 also also ADV bam-1807 84 30 play play VERB bam-1807 84 31 a a DET bam-1807 84 32 role role NOUN bam-1807 84 33 in in ADP bam-1807 84 34 muscle muscle NOUN bam-1807 84 35 hypertrophy hypertrophy NOUN bam-1807 84 36 . . PUNCT bam-1807 85 1 in in ADP bam-1807 85 2 fact fact NOUN bam-1807 85 3 , , PUNCT bam-1807 85 4 activation activation NOUN bam-1807 85 5 of of ADP bam-1807 85 6 beta2 beta2 NOUN bam-1807 85 7 adrenoreceptors adrenoreceptor NOUN bam-1807 85 8 by by ADP bam-1807 85 9 beta beta NOUN bam-1807 85 10 - - PUNCT bam-1807 85 11 agonists agonist NOUN bam-1807 85 12 is be AUX bam-1807 85 13 known know VERB bam-1807 85 14 to to PART bam-1807 85 15 cause cause VERB bam-1807 85 16 muscle muscle NOUN bam-1807 85 17 hypertrophy hypertrophy NOUN bam-1807 85 18 and and CCONJ bam-1807 85 19 a a DET bam-1807 85 20 slow slow ADJ bam-1807 85 21 - - PUNCT bam-1807 85 22 to to ADP bam-1807 85 23 - - PUNCT bam-1807 85 24 fast fast VERB bam-1807 85 25 fiber fiber NOUN bam-1807 85 26 - - PUNCT bam-1807 85 27 type type NOUN bam-1807 85 28 switch switch NOUN bam-1807 85 29 , , PUNCT bam-1807 85 30 by by ADP bam-1807 85 31 acting act VERB bam-1807 85 32 through through ADP bam-1807 85 33 the the DET bam-1807 85 34 akt akt PROPN bam-1807 85 35 - - PUNCT bam-1807 85 36 mtor mtor PROPN bam-1807 85 37 pathway pathway NOUN bam-1807 86 1 [ [ X bam-1807 86 2 53 53 NUM bam-1807 86 3 ] ] PUNCT bam-1807 86 4 . . PUNCT bam-1807 87 1 mechanical mechanical ADJ bam-1807 87 2 stimuli stimulus NOUN bam-1807 87 3 activate activate VERB bam-1807 87 4 mtor mtor NOUN bam-1807 87 5 , , PUNCT bam-1807 87 6 without without ADP bam-1807 87 7 inducing induce VERB bam-1807 87 8 akt akt PROPN bam-1807 87 9 phosphorylation phosphorylation NOUN bam-1807 88 1 [ [ X bam-1807 88 2 41 41 NUM bam-1807 88 3 ] ] PUNCT bam-1807 88 4 . . PUNCT bam-1807 89 1 muscle muscle NOUN bam-1807 89 2 activity activity NOUN bam-1807 89 3 itself itself PRON bam-1807 89 4 promotes promote VERB bam-1807 89 5 a a DET bam-1807 89 6 number number NOUN bam-1807 89 7 of of ADP bam-1807 89 8 mechanotransduction mechanotransduction NOUN bam-1807 89 9 signals signal NOUN bam-1807 89 10 , , PUNCT bam-1807 89 11 which which PRON bam-1807 89 12 are be AUX bam-1807 89 13 involved involve VERB bam-1807 89 14 in in ADP bam-1807 89 15 muscle muscle NOUN bam-1807 89 16 hypertrophic hypertrophic ADJ bam-1807 89 17 response response NOUN bam-1807 89 18 [ [ X bam-1807 89 19 124 124 NUM bam-1807 89 20 ] ] PUNCT bam-1807 89 21 . . PUNCT bam-1807 90 1 in in ADP bam-1807 90 2 the the DET bam-1807 90 3 sarcomere sarcomere NOUN bam-1807 90 4 , , PUNCT bam-1807 90 5 the the DET bam-1807 90 6 basic basic ADJ bam-1807 90 7 unit unit NOUN bam-1807 90 8 of of ADP bam-1807 90 9 striated striated ADJ bam-1807 90 10 muscles muscle NOUN bam-1807 90 11 where where SCONJ bam-1807 90 12 contractile contractile NOUN bam-1807 90 13 force force NOUN bam-1807 90 14 originates originate NOUN bam-1807 90 15 , , PUNCT bam-1807 90 16 dozens dozen NOUN bam-1807 90 17 of of ADP bam-1807 90 18 proteins protein NOUN bam-1807 90 19 interact interact VERB bam-1807 90 20 with with ADP bam-1807 90 21 each each DET bam-1807 90 22 other other ADJ bam-1807 90 23 and and CCONJ bam-1807 90 24 relocalize relocalize VERB bam-1807 90 25 following follow VERB bam-1807 90 26 mechanical mechanical ADJ bam-1807 90 27 stress stress NOUN bam-1807 90 28 or or CCONJ bam-1807 90 29 extracellular extracellular ADJ bam-1807 90 30 signals signal NOUN bam-1807 90 31 . . PUNCT bam-1807 91 1 one one NUM bam-1807 91 2 of of ADP bam-1807 91 3 these these PRON bam-1807 91 4 , , PUNCT bam-1807 91 5 the the DET bam-1807 91 6 giant giant ADJ bam-1807 91 7 protein protein NOUN bam-1807 91 8 titin titin PROPN bam-1807 91 9 ( ( PUNCT bam-1807 91 10 also also ADV bam-1807 91 11 called call VERB bam-1807 91 12 connectin connectin NOUN bam-1807 91 13 ; ; PUNCT bam-1807 91 14 [ [ X bam-1807 91 15 115 115 NUM bam-1807 91 16 ] ] PUNCT bam-1807 91 17 ) ) PUNCT bam-1807 91 18 is be AUX bam-1807 91 19 endowed endow VERB bam-1807 91 20 of of ADP bam-1807 91 21 a a DET bam-1807 91 22 kinase kinase NOUN bam-1807 91 23 domain domain NOUN bam-1807 91 24 that that PRON bam-1807 91 25 regulates regulate VERB bam-1807 91 26 the the DET bam-1807 91 27 translocation translocation NOUN bam-1807 91 28 to to ADP bam-1807 91 29 the the DET bam-1807 91 30 nucleus nucleus NOUN bam-1807 91 31 of of ADP bam-1807 91 32 murf2 murf2 PROPN bam-1807 91 33 , , PUNCT bam-1807 91 34 a a DET bam-1807 91 35 member member NOUN bam-1807 91 36 of of ADP bam-1807 91 37 the the DET bam-1807 91 38 muscle muscle NOUN bam-1807 91 39 - - PUNCT bam-1807 91 40 specific specific ADJ bam-1807 91 41 ring ring NOUN bam-1807 91 42 - - PUNCT bam-1807 91 43 finger finger NOUN bam-1807 91 44 proteins protein NOUN bam-1807 91 45 . . PUNCT bam-1807 92 1 in in ADP bam-1807 92 2 the the DET bam-1807 92 3 nucleus nucleus NOUN bam-1807 92 4 , , PUNCT bam-1807 92 5 murf2 murf2 ADJ bam-1807 92 6 interacts interact VERB bam-1807 92 7 with with ADP bam-1807 92 8 srf srf PROPN bam-1807 92 9 , , PUNCT bam-1807 92 10 the the DET bam-1807 92 11 serum serum NOUN bam-1807 92 12 response response NOUN bam-1807 92 13 transcription transcription NOUN bam-1807 92 14 factor factor NOUN bam-1807 92 15 , , PUNCT bam-1807 92 16 thus thus ADV bam-1807 92 17 contributing contribute VERB bam-1807 92 18 to to ADP bam-1807 92 19 the the DET bam-1807 92 20 regulation regulation NOUN bam-1807 92 21 of of ADP bam-1807 92 22 muscle muscle NOUN bam-1807 92 23 - - PUNCT bam-1807 92 24 specific specific ADJ bam-1807 92 25 genes gene NOUN bam-1807 92 26 [ [ X bam-1807 92 27 59 59 NUM bam-1807 92 28 ] ] PUNCT bam-1807 92 29 . . PUNCT bam-1807 93 1 another another DET bam-1807 93 2 source source NOUN bam-1807 93 3 of of ADP bam-1807 93 4 mechanotransduction mechanotransduction NOUN bam-1807 93 5 signals signal NOUN bam-1807 93 6 are be AUX bam-1807 93 7 the the DET bam-1807 93 8 structures structure NOUN bam-1807 93 9 connecting connect VERB bam-1807 93 10 the the DET bam-1807 93 11 extracellular extracellular ADJ bam-1807 93 12 matrix matrix NOUN bam-1807 93 13 to to ADP bam-1807 93 14 the the DET bam-1807 93 15 muscle muscle NOUN bam-1807 93 16 cell cell NOUN bam-1807 93 17 membrane membrane NOUN bam-1807 93 18 ( ( PUNCT bam-1807 93 19 and and CCONJ bam-1807 93 20 z z NOUN bam-1807 93 21 discs disc NOUN bam-1807 93 22 ) ) PUNCT bam-1807 94 1 [ [ X bam-1807 94 2 45 45 NUM bam-1807 94 3 ] ] X bam-1807 94 4 ; ; PUNCT bam-1807 94 5 in in ADP bam-1807 94 6 particular particular ADJ bam-1807 94 7 , , PUNCT bam-1807 94 8 integrins integrin NOUN bam-1807 94 9 have have AUX bam-1807 94 10 been be AUX bam-1807 94 11 advocated advocate VERB bam-1807 94 12 as as ADP bam-1807 94 13 important important ADJ bam-1807 94 14 regulators regulator NOUN bam-1807 94 15 of of ADP bam-1807 94 16 the the DET bam-1807 94 17 mtor mtor PROPN bam-1807 94 18 pathway pathway NOUN bam-1807 94 19 ( ( PUNCT bam-1807 94 20 see see VERB bam-1807 94 21 discussion discussion NOUN bam-1807 94 22 in in ADP bam-1807 94 23 [ [ X bam-1807 94 24 124 124 NUM bam-1807 94 25 ] ] PUNCT bam-1807 94 26 ) ) PUNCT bam-1807 94 27 . . PUNCT bam-1807 95 1 the the DET bam-1807 95 2 expression expression NOUN bam-1807 95 3 and/or and/or CCONJ bam-1807 95 4 the the DET bam-1807 95 5 phosphorylation phosphorylation NOUN bam-1807 95 6 state state NOUN bam-1807 95 7 of of ADP bam-1807 95 8 some some DET bam-1807 95 9 components component NOUN bam-1807 95 10 of of ADP bam-1807 95 11 the the DET bam-1807 95 12 dystrophin dystrophin NOUN bam-1807 95 13 - - PUNCT bam-1807 95 14 associated associate VERB bam-1807 95 15 protein protein NOUN bam-1807 95 16 complex complex NOUN bam-1807 95 17 ( ( PUNCT bam-1807 95 18 dapc dapc NOUN bam-1807 95 19 ) ) PUNCT bam-1807 95 20 were be AUX bam-1807 95 21 also also ADV bam-1807 95 22 found find VERB bam-1807 95 23 to to PART bam-1807 95 24 be be AUX bam-1807 95 25 affected affect VERB bam-1807 95 26 by by ADP bam-1807 95 27 strength strength NOUN bam-1807 95 28 training training NOUN bam-1807 95 29 [ [ X bam-1807 95 30 55 55 NUM bam-1807 95 31 ] ] PUNCT bam-1807 95 32 . . PUNCT bam-1807 96 1 it it PRON bam-1807 96 2 is be AUX bam-1807 96 3 known know VERB bam-1807 96 4 that that SCONJ bam-1807 96 5 mechanical mechanical ADJ bam-1807 96 6 activity activity NOUN bam-1807 96 7 of of ADP bam-1807 96 8 the the DET bam-1807 96 9 muscle muscle NOUN bam-1807 96 10 increases increase VERB bam-1807 96 11 the the DET bam-1807 96 12 concentration concentration NOUN bam-1807 96 13 of of ADP bam-1807 96 14 phosphatidic phosphatidic ADJ bam-1807 96 15 acid acid NOUN bam-1807 96 16 ( ( PUNCT bam-1807 96 17 pa pa PROPN bam-1807 96 18 ) ) PUNCT bam-1807 96 19 , , PUNCT bam-1807 96 20 which which PRON bam-1807 96 21 binds bind VERB bam-1807 96 22 the the DET bam-1807 96 23 frb frb NOUN bam-1807 96 24 domain domain NOUN bam-1807 96 25 of of ADP bam-1807 96 26 mtor mtor NOUN bam-1807 96 27 and and CCONJ bam-1807 96 28 activates activate VERB bam-1807 96 29 p70s6k p70s6k PROPN bam-1807 96 30 activity activity NOUN bam-1807 96 31 ; ; PUNCT bam-1807 96 32 in in ADP bam-1807 96 33 turn turn NOUN bam-1807 96 34 , , PUNCT bam-1807 96 35 pa pa PROPN bam-1807 96 36 is be AUX bam-1807 96 37 generated generate VERB bam-1807 96 38 by by ADP bam-1807 96 39 the the DET bam-1807 96 40 activity activity NOUN bam-1807 96 41 of of ADP bam-1807 96 42 the the DET bam-1807 96 43 phospholipase phospholipase PROPN bam-1807 96 44 d d PROPN bam-1807 96 45 ( ( PUNCT bam-1807 96 46 pld pld NOUN bam-1807 96 47 ) ) PUNCT bam-1807 96 48 , , PUNCT bam-1807 96 49 which which PRON bam-1807 96 50 hydrolyses hydrolyse VERB bam-1807 96 51 phosphatidilcholine phosphatidilcholine NOUN bam-1807 96 52 in in ADP bam-1807 96 53 pa pa PROPN bam-1807 96 54 and and CCONJ bam-1807 96 55 choline choline VERB bam-1807 96 56 and and CCONJ bam-1807 96 57 is be AUX bam-1807 96 58 associated associate VERB bam-1807 96 59 with with ADP bam-1807 96 60 α α NOUN bam-1807 96 61 - - NOUN bam-1807 96 62 actinin actinin NOUN bam-1807 96 63 and and CCONJ bam-1807 96 64 βactin βactin PROPN bam-1807 96 65 . . PUNCT bam-1807 97 1 since since SCONJ bam-1807 97 2 α α NOUN bam-1807 97 3 - - NOUN bam-1807 97 4 actinin actinin NOUN bam-1807 97 5 and and CCONJ bam-1807 97 6 β β NOUN bam-1807 97 7 - - NOUN bam-1807 97 8 actin actin NOUN bam-1807 97 9 are be AUX bam-1807 97 10 components component NOUN bam-1807 97 11 of of ADP bam-1807 97 12 dapc dapc NOUN bam-1807 97 13 , , PUNCT bam-1807 97 14 it it PRON bam-1807 97 15 is be AUX bam-1807 97 16 suggestive suggestive ADJ bam-1807 97 17 to to PART bam-1807 97 18 postulate postulate VERB bam-1807 97 19 that that DET bam-1807 97 20 muscle muscle NOUN bam-1807 97 21 contraction contraction NOUN bam-1807 97 22 favors favor VERB bam-1807 97 23 the the DET bam-1807 97 24 activation activation NOUN bam-1807 97 25 of of ADP bam-1807 97 26 pld pld NOUN bam-1807 97 27 , , PUNCT bam-1807 97 28 and and CCONJ bam-1807 97 29 hence hence ADV bam-1807 97 30 pa pa PROPN bam-1807 97 31 generation generation NOUN bam-1807 97 32 , , PUNCT bam-1807 97 33 by by ADP bam-1807 97 34 favoring favor VERB bam-1807 97 35 its its PRON bam-1807 97 36 physical physical ADJ bam-1807 97 37 dissociation dissociation NOUN bam-1807 97 38 from from ADP bam-1807 97 39 α α NOUN bam-1807 97 40 - - NOUN bam-1807 97 41 actinin actinin NOUN bam-1807 97 42 and/or and/or CCONJ bam-1807 97 43 β β NOUN bam-1807 97 44 - - NOUN bam-1807 97 45 actin actin NOUN bam-1807 97 46 . . PUNCT bam-1807 98 1 also also ADV bam-1807 98 2 nutrients nutrient NOUN bam-1807 98 3 , , PUNCT bam-1807 98 4 especially especially ADV bam-1807 98 5 amino amino ADJ bam-1807 98 6 acids acid NOUN bam-1807 98 7 , , PUNCT bam-1807 98 8 activate activate VERB bam-1807 98 9 mtor mtor NOUN bam-1807 98 10 . . PUNCT bam-1807 99 1 it it PRON bam-1807 99 2 appears appear VERB bam-1807 99 3 that that SCONJ bam-1807 99 4 the the DET bam-1807 99 5 amino amino NOUN bam-1807 99 6 acid acid NOUN bam-1807 99 7 leucine leucine NOUN bam-1807 99 8 has have VERB bam-1807 99 9 the the DET bam-1807 99 10 most most ADV bam-1807 99 11 powerful powerful ADJ bam-1807 99 12 effect effect NOUN bam-1807 99 13 on on ADP bam-1807 99 14 the the DET bam-1807 99 15 phosphorylation phosphorylation NOUN bam-1807 99 16 state state NOUN bam-1807 99 17 of of ADP bam-1807 99 18 p70s6k p70s6k PROPN bam-1807 99 19 in in ADP bam-1807 99 20 the the DET bam-1807 99 21 skeletal skeletal ADJ bam-1807 99 22 muscle muscle NOUN bam-1807 99 23 . . PUNCT bam-1807 100 1 the the DET bam-1807 100 2 mechanism mechanism NOUN bam-1807 100 3 by by ADP bam-1807 100 4 which which PRON bam-1807 100 5 amino amino NOUN bam-1807 100 6 acids acid NOUN bam-1807 100 7 activate activate VERB bam-1807 100 8 mtor mtor NOUN bam-1807 100 9 is be AUX bam-1807 100 10 still still ADV bam-1807 100 11 controversial controversial ADJ bam-1807 100 12 [ [ X bam-1807 100 13 18 18 NUM bam-1807 100 14 , , PUNCT bam-1807 100 15 32 32 NUM bam-1807 100 16 ] ] PUNCT bam-1807 100 17 , , PUNCT bam-1807 100 18 though though SCONJ bam-1807 100 19 it it PRON bam-1807 100 20 is be AUX bam-1807 100 21 known know VERB bam-1807 100 22 that that SCONJ bam-1807 100 23 the the DET bam-1807 100 24 small small ADJ bam-1807 100 25 gtpase gtpase NOUN bam-1807 100 26 rheb rheb NOUN bam-1807 100 27 is be AUX bam-1807 100 28 involved involve VERB bam-1807 100 29 in in ADP bam-1807 100 30 the the DET bam-1807 100 31 activation activation NOUN bam-1807 100 32 . . PUNCT bam-1807 101 1 in in ADP bam-1807 101 2 fact fact NOUN bam-1807 101 3 , , PUNCT bam-1807 101 4 when when SCONJ bam-1807 101 5 rheb rheb ADJ bam-1807 101 6 is be AUX bam-1807 101 7 bound bind VERB bam-1807 101 8 to to ADP bam-1807 101 9 gtp gtp PROPN bam-1807 101 10 , , PUNCT bam-1807 101 11 mtor mtor PROPN bam-1807 101 12 is be AUX bam-1807 101 13 activated activate VERB bam-1807 101 14 . . PUNCT bam-1807 102 1 the the DET bam-1807 102 2 gtpaseactivating gtpaseactivate VERB bam-1807 102 3 protein protein NOUN bam-1807 102 4 that that PRON bam-1807 102 5 promotes promote VERB bam-1807 102 6 rheb rheb ADJ bam-1807 102 7 detachment detachment NOUN bam-1807 102 8 from from ADP bam-1807 102 9 mtor mtor NOUN bam-1807 102 10 and and CCONJ bam-1807 102 11 hence hence ADV bam-1807 102 12 mtor mtor NOUN bam-1807 102 13 inactivation inactivation NOUN bam-1807 102 14 is be AUX bam-1807 102 15 the the DET bam-1807 102 16 gap gap NOUN bam-1807 102 17 domain domain NOUN bam-1807 102 18 of of ADP bam-1807 102 19 tsc2 tsc2 PROPN bam-1807 102 20 . . PUNCT bam-1807 103 1 tsc1 tsc1 PROPN bam-1807 103 2 and and CCONJ bam-1807 103 3 tsc2 tsc2 PROPN bam-1807 103 4 ( ( PUNCT bam-1807 103 5 tuberous tuberous ADJ bam-1807 103 6 sclerosis sclerosis NOUN bam-1807 103 7 complex complex NOUN bam-1807 103 8 1 1 NUM bam-1807 103 9 and and CCONJ bam-1807 103 10 2 2 NUM bam-1807 103 11 ) ) PUNCT bam-1807 103 12 , , PUNCT bam-1807 103 13 also also ADV bam-1807 103 14 called call VERB bam-1807 103 15 hamartin hamartin NOUN bam-1807 103 16 and and CCONJ bam-1807 103 17 tuberin tuberin NOUN bam-1807 103 18 respectively respectively ADV bam-1807 103 19 , , PUNCT bam-1807 103 20 form form VERB bam-1807 103 21 a a DET bam-1807 103 22 complex complex NOUN bam-1807 103 23 that that PRON bam-1807 103 24 represses repress VERB bam-1807 103 25 mtor mtor NOUN bam-1807 103 26 . . PUNCT bam-1807 104 1 this this DET bam-1807 104 2 inhibition inhibition NOUN bam-1807 104 3 on on ADP bam-1807 104 4 mtor mtor NOUN bam-1807 104 5 can can AUX bam-1807 104 6 be be AUX bam-1807 104 7 reversed reverse VERB bam-1807 104 8 when when SCONJ bam-1807 104 9 tsc2 tsc2 PROPN bam-1807 104 10 is be AUX bam-1807 104 11 phosphorylated phosphorylate VERB bam-1807 104 12 by by ADP bam-1807 104 13 pkb pkb PROPN bam-1807 104 14 , , PUNCT bam-1807 104 15 which which PRON bam-1807 104 16 induces induce VERB bam-1807 104 17 the the DET bam-1807 104 18 dissociation dissociation NOUN bam-1807 104 19 of of ADP bam-1807 104 20 the the DET bam-1807 104 21 complex complex NOUN bam-1807 104 22 . . PUNCT bam-1807 105 1 however however ADV bam-1807 105 2 , , PUNCT bam-1807 105 3 whether whether SCONJ bam-1807 105 4 high high ADJ bam-1807 105 5 concentrations concentration NOUN bam-1807 105 6 of of ADP bam-1807 105 7 amino amino ADJ bam-1807 105 8 acids acid NOUN bam-1807 105 9 activate activate VERB bam-1807 105 10 pkb pkb PROPN bam-1807 105 11 is be AUX bam-1807 105 12 not not PART bam-1807 105 13 well well ADV bam-1807 105 14 understood understand VERB bam-1807 105 15 [ [ X bam-1807 105 16 42 42 NUM bam-1807 105 17 ] ] PUNCT bam-1807 105 18 . . PUNCT bam-1807 106 1 since since SCONJ bam-1807 106 2 mtor mtor PROPN bam-1807 106 3 activation activation NOUN bam-1807 106 4 results result VERB bam-1807 106 5 in in ADP bam-1807 106 6 energy energy NOUN bam-1807 106 7 - - PUNCT bam-1807 106 8 requiring require VERB bam-1807 106 9 processes process NOUN bam-1807 106 10 , , PUNCT bam-1807 106 11 such such ADJ bam-1807 106 12 as as ADP bam-1807 106 13 the the DET bam-1807 106 14 upregulation upregulation NOUN bam-1807 106 15 of of ADP bam-1807 106 16 protein protein NOUN bam-1807 106 17 synthesis synthesis NOUN bam-1807 106 18 and and CCONJ bam-1807 106 19 , , PUNCT bam-1807 106 20 in in ADP bam-1807 106 21 non non ADJ bam-1807 106 22 - - ADJ bam-1807 106 23 muscle muscle ADJ bam-1807 106 24 cells cell NOUN bam-1807 106 25 , , PUNCT bam-1807 106 26 in in ADP bam-1807 106 27 cell cell NOUN bam-1807 106 28 cycle cycle NOUN bam-1807 106 29 promotion promotion NOUN bam-1807 106 30 , , PUNCT bam-1807 106 31 it it PRON bam-1807 106 32 is be AUX bam-1807 106 33 not not PART bam-1807 106 34 surprising surprising ADJ bam-1807 106 35 that that SCONJ bam-1807 106 36 also also ADV bam-1807 106 37 the the DET bam-1807 106 38 energy energy NOUN bam-1807 106 39 status status NOUN bam-1807 106 40 of of ADP bam-1807 106 41 the the DET bam-1807 106 42 cell cell NOUN bam-1807 106 43 regulates regulate VERB bam-1807 106 44 mtor mtor NOUN bam-1807 106 45 activation activation NOUN bam-1807 106 46 . . PUNCT bam-1807 107 1 athletes athlete NOUN bam-1807 107 2 involved involve VERB bam-1807 107 3 in in ADP bam-1807 107 4 resistance resistance NOUN bam-1807 107 5 training training NOUN bam-1807 107 6 are be AUX bam-1807 107 7 encouraged encourage VERB bam-1807 107 8 to to PART bam-1807 107 9 ingest ingest VERB bam-1807 107 10 carbohydrates carbohydrate NOUN bam-1807 107 11 before before ADP bam-1807 107 12 a a DET bam-1807 107 13 training training NOUN bam-1807 107 14 session session NOUN bam-1807 107 15 , , PUNCT bam-1807 107 16 in in ADP bam-1807 107 17 order order NOUN bam-1807 107 18 to to PART bam-1807 107 19 increase increase VERB bam-1807 107 20 muscle muscle NOUN bam-1807 107 21 mass mass NOUN bam-1807 108 1 [ [ X bam-1807 108 2 114 114 NUM bam-1807 108 3 ] ] PUNCT bam-1807 108 4 ; ; PUNCT bam-1807 108 5 moreover moreover ADV bam-1807 108 6 , , PUNCT bam-1807 108 7 it it PRON bam-1807 108 8 seems seem VERB bam-1807 108 9 that that SCONJ bam-1807 108 10 a a DET bam-1807 108 11 minimal minimal ADJ bam-1807 108 12 insulin insulin NOUN bam-1807 108 13 concentration concentration NOUN bam-1807 108 14 – – PUNCT bam-1807 108 15 by by ADP bam-1807 108 16 itself itself PRON bam-1807 108 17 a a DET bam-1807 108 18 signal signal NOUN bam-1807 108 19 of of ADP bam-1807 108 20 energy energy NOUN bam-1807 108 21 availability availability NOUN bam-1807 108 22 – – PUNCT bam-1807 108 23 is be AUX bam-1807 108 24 required require VERB bam-1807 108 25 for for ADP bam-1807 108 26 mtor mtor NOUN bam-1807 108 27 stimulation stimulation NOUN bam-1807 108 28 by by ADP bam-1807 108 29 amino amino ADJ bam-1807 108 30 acids acid NOUN bam-1807 108 31 . . PUNCT bam-1807 109 1 on on ADP bam-1807 109 2 the the DET bam-1807 109 3 other other ADJ bam-1807 109 4 hand hand NOUN bam-1807 109 5 , , PUNCT bam-1807 109 6 a a DET bam-1807 109 7 fall fall NOUN bam-1807 109 8 in in ADP bam-1807 109 9 atp atp NOUN bam-1807 109 10 concentration concentration NOUN bam-1807 109 11 indirectly indirectly ADV bam-1807 109 12 inhibits inhibit VERB bam-1807 109 13 the the DET bam-1807 109 14 mtor mtor PROPN bam-1807 109 15 pathway pathway NOUN bam-1807 109 16 through through ADP bam-1807 109 17 the the DET bam-1807 109 18 action action NOUN bam-1807 109 19 of of ADP bam-1807 109 20 amp amp PROPN bam-1807 109 21 kinase kinase PROPN bam-1807 109 22 ( ( PUNCT bam-1807 109 23 ampk ampk PROPN bam-1807 109 24 ) ) PUNCT bam-1807 109 25 . . PUNCT bam-1807 110 1 ampk ampk NOUN bam-1807 110 2 is be AUX bam-1807 110 3 a a DET bam-1807 110 4 sensor sensor NOUN bam-1807 110 5 of of ADP bam-1807 110 6 energy energy NOUN bam-1807 110 7 shortage shortage NOUN bam-1807 110 8 ; ; PUNCT bam-1807 110 9 in in ADP bam-1807 110 10 fact fact NOUN bam-1807 110 11 it it PRON bam-1807 110 12 is be AUX bam-1807 110 13 activated activate VERB bam-1807 110 14 by by ADP bam-1807 110 15 high high ADJ bam-1807 110 16 concentration concentration NOUN bam-1807 110 17 of of ADP bam-1807 110 18 amp amp NOUN bam-1807 110 19 , , PUNCT bam-1807 110 20 and and CCONJ bam-1807 110 21 acts act VERB bam-1807 110 22 by by ADP bam-1807 110 23 increasing increase VERB bam-1807 110 24 energy energy NOUN bam-1807 110 25 availability availability NOUN bam-1807 110 26 and and CCONJ bam-1807 110 27 decreasing decrease VERB bam-1807 110 28 atp atp NOUN bam-1807 110 29 consumption consumption NOUN bam-1807 110 30 . . PUNCT bam-1807 111 1 to to ADP bam-1807 111 2 this this DET bam-1807 111 3 purpose purpose NOUN bam-1807 111 4 , , PUNCT bam-1807 111 5 ampk ampk NOUN bam-1807 111 6 , , PUNCT bam-1807 111 7 by by ADP bam-1807 111 8 phosphorylating phosphorylate VERB bam-1807 111 9 tsc2 tsc2 PROPN bam-1807 111 10 , , PUNCT bam-1807 111 11 enhances enhance VERB bam-1807 111 12 its its PRON bam-1807 111 13 activity activity NOUN bam-1807 111 14 , , PUNCT bam-1807 111 15 leading lead VERB bam-1807 111 16 to to ADP bam-1807 111 17 a a DET bam-1807 111 18 decrease decrease NOUN bam-1807 111 19 in in ADP bam-1807 111 20 mtor mtor NOUN bam-1807 111 21 activity activity NOUN bam-1807 111 22 [ [ X bam-1807 111 23 ( ( PUNCT bam-1807 111 24 46 46 NUM bam-1807 111 25 ] ] PUNCT bam-1807 111 26 . . PUNCT bam-1807 112 1 additionally additionally ADV bam-1807 112 2 , , PUNCT bam-1807 112 3 ampk ampk NOUN bam-1807 112 4 can can AUX bam-1807 112 5 directly directly ADV bam-1807 112 6 phosphorylate phosphorylate VERB bam-1807 112 7 the the DET bam-1807 112 8 mtor mtor NOUN bam-1807 112 9 binding bind VERB bam-1807 112 10 partner partner NOUN bam-1807 112 11 raptor raptor NOUN bam-1807 112 12 , , PUNCT bam-1807 112 13 thus thus ADV bam-1807 112 14 leading lead VERB bam-1807 112 15 to to ADP bam-1807 112 16 the the DET bam-1807 112 17 inhibition inhibition NOUN bam-1807 112 18 of of ADP bam-1807 112 19 mtor mtor NOUN bam-1807 112 20 activity activity NOUN bam-1807 112 21 [ [ X bam-1807 112 22 35 35 NUM bam-1807 112 23 ] ] PUNCT bam-1807 112 24 . . PUNCT bam-1807 113 1 in in ADP bam-1807 113 2 this this DET bam-1807 113 3 way way NOUN bam-1807 113 4 , , PUNCT bam-1807 113 5 the the DET bam-1807 113 6 effect effect NOUN bam-1807 113 7 of of ADP bam-1807 113 8 cellular cellular ADJ bam-1807 113 9 energy energy NOUN bam-1807 113 10 stress stress NOUN bam-1807 113 11 directly directly ADV bam-1807 113 12 reflects reflect VERB bam-1807 113 13 on on ADP bam-1807 113 14 the the DET bam-1807 113 15 mtor mtor PROPN bam-1807 113 16 pathway pathway NOUN bam-1807 113 17 via via ADP bam-1807 113 18 ampk ampk NOUN bam-1807 113 19 activation activation NOUN bam-1807 113 20 . . PUNCT bam-1807 114 1 the the DET bam-1807 114 2 downstream downstream ADJ bam-1807 114 3 effectors effector NOUN bam-1807 114 4 of of ADP bam-1807 114 5 mtor mtor PROPN bam-1807 114 6 lead lead VERB bam-1807 114 7 to to ADP bam-1807 114 8 increased increase VERB bam-1807 114 9 ribosome ribosome ADJ bam-1807 114 10 biogenesis biogenesis NOUN bam-1807 114 11 and and CCONJ bam-1807 114 12 to to ADP bam-1807 114 13 increased increase VERB bam-1807 114 14 translation translation NOUN bam-1807 114 15 . . PUNCT bam-1807 115 1 in in ADP bam-1807 115 2 fact fact NOUN bam-1807 115 3 , , PUNCT bam-1807 115 4 ribosome ribosome ADJ bam-1807 115 5 biogenesis biogenesis NOUN bam-1807 115 6 is be AUX bam-1807 115 7 an an DET bam-1807 115 8 energy energy NOUN bam-1807 115 9 consuming consume VERB bam-1807 115 10 process process NOUN bam-1807 115 11 ; ; PUNCT bam-1807 115 12 hence hence ADV bam-1807 115 13 its its PRON bam-1807 115 14 level level NOUN bam-1807 115 15 is be AUX bam-1807 115 16 strictly strictly ADV bam-1807 115 17 correlated correlate VERB bam-1807 115 18 to to ADP bam-1807 115 19 the the DET bam-1807 115 20 energy energy NOUN bam-1807 115 21 availability availability NOUN bam-1807 115 22 , , PUNCT bam-1807 115 23 as as ADV bam-1807 115 24 well well ADV bam-1807 115 25 as as ADP bam-1807 115 26 to to ADP bam-1807 115 27 the the DET bam-1807 115 28 translation translation NOUN bam-1807 115 29 needs need VERB bam-1807 115 30 . . PUNCT bam-1807 116 1 torc1 torc1 DET bam-1807 116 2 complex complex NOUN bam-1807 116 3 is be AUX bam-1807 116 4 involved involve VERB bam-1807 116 5 in in ADP bam-1807 116 6 the the DET bam-1807 116 7 activation activation NOUN bam-1807 116 8 of of ADP bam-1807 116 9 ( ( PUNCT bam-1807 116 10 i i NOUN bam-1807 116 11 ) ) PUNCT bam-1807 116 12 rna rna NOUN bam-1807 116 13 polymerase polymerase NOUN bam-1807 117 1 i i PRON bam-1807 117 2 ( ( PUNCT bam-1807 117 3 pol pol PROPN bam-1807 117 4 i)-dependent i)-dependent NUM bam-1807 117 5 rrna rrna PROPN bam-1807 117 6 genes gene NOUN bam-1807 117 7 , , PUNCT bam-1807 117 8 ( ( PUNCT bam-1807 117 9 ii ii NOUN bam-1807 117 10 ) ) PUNCT bam-1807 117 11 pol pol PROPN bam-1807 117 12 ii ii PROPN bam-1807 117 13 - - PUNCT bam-1807 117 14 dependent dependent ADJ bam-1807 117 15 ribosomal ribosomal NOUN bam-1807 117 16 protein protein NOUN bam-1807 117 17 genes gene NOUN bam-1807 117 18 ( ( PUNCT bam-1807 117 19 rp rp NOUN bam-1807 117 20 genes gene NOUN bam-1807 117 21 ) ) PUNCT bam-1807 117 22 , , PUNCT bam-1807 117 23 ( ( PUNCT bam-1807 117 24 iii iii X bam-1807 117 25 ) ) PUNCT bam-1807 117 26 pol pol PROPN bam-1807 117 27 iii iii PROPN bam-1807 117 28 - - PUNCT bam-1807 117 29 dependent dependent ADJ bam-1807 117 30 rrna rrna NOUN bam-1807 117 31 genes gene NOUN bam-1807 117 32 ; ; PUNCT bam-1807 117 33 moreover moreover ADV bam-1807 117 34 , , PUNCT bam-1807 117 35 it it PRON bam-1807 117 36 also also ADV bam-1807 117 37 controls control VERB bam-1807 117 38 the the DET bam-1807 117 39 processing processing NOUN bam-1807 117 40 of of ADP bam-1807 117 41 the the DET bam-1807 117 42 35s 35 NOUN bam-1807 117 43 rrna rrna NOUN bam-1807 117 44 precursor precursor NOUN bam-1807 117 45 [ [ X bam-1807 117 46 68 68 NUM bam-1807 117 47 ] ] PUNCT bam-1807 117 48 . . PUNCT bam-1807 118 1 translation translation NOUN bam-1807 118 2 is be AUX bam-1807 118 3 activated activate VERB bam-1807 118 4 by by ADP bam-1807 118 5 the the DET bam-1807 118 6 torc1 torc1 PROPN bam-1807 118 7 complex complex NOUN bam-1807 118 8 through through ADP bam-1807 118 9 ( ( PUNCT bam-1807 118 10 i i NOUN bam-1807 118 11 ) ) PUNCT bam-1807 118 12 the the DET bam-1807 118 13 activation activation NOUN bam-1807 118 14 of of ADP bam-1807 118 15 p70s6k p70s6k PROPN bam-1807 118 16 , , PUNCT bam-1807 118 17 which which PRON bam-1807 118 18 causes cause VERB bam-1807 118 19 the the DET bam-1807 118 20 phosphorylation phosphorylation NOUN bam-1807 118 21 of of ADP bam-1807 118 22 a a DET bam-1807 118 23 subclass subclass NOUN bam-1807 118 24 of of ADP bam-1807 118 25 mrnas mrna NOUN bam-1807 118 26 encoding encode VERB bam-1807 118 27 elongation elongation NOUN bam-1807 118 28 factors factor NOUN bam-1807 118 29 and and CCONJ bam-1807 118 30 ribosomal ribosomal NOUN bam-1807 118 31 proteins protein NOUN bam-1807 118 32 , , PUNCT bam-1807 118 33 thus thus ADV bam-1807 118 34 enhancing enhance VERB bam-1807 118 35 the the DET bam-1807 118 36 global global ADJ bam-1807 118 37 translation translation NOUN bam-1807 118 38 capacity capacity NOUN bam-1807 118 39 of of ADP bam-1807 118 40 the the DET bam-1807 118 41 cell cell NOUN bam-1807 118 42 ; ; PUNCT bam-1807 118 43 ( ( PUNCT bam-1807 118 44 ii ii NOUN bam-1807 118 45 ) ) PUNCT bam-1807 118 46 the the DET bam-1807 118 47 phosphorylation phosphorylation NOUN bam-1807 118 48 of of ADP bam-1807 118 49 4e 4e PROPN bam-1807 118 50 - - PUNCT bam-1807 118 51 bp1 bp1 PROPN bam-1807 118 52 , , PUNCT bam-1807 118 53 which which PRON bam-1807 118 54 releases release VERB bam-1807 118 55 the the DET bam-1807 118 56 eukaryotic eukaryotic ADJ bam-1807 118 57 initiation initiation NOUN bam-1807 118 58 factor factor NOUN bam-1807 118 59 eif4e eif4e PROPN bam-1807 118 60 , , PUNCT bam-1807 118 61 the the DET bam-1807 118 62 limiting limit VERB bam-1807 118 63 component component NOUN bam-1807 118 64 of of ADP bam-1807 118 65 the the DET bam-1807 118 66 multisubunit multisubunit NOUN bam-1807 118 67 complex complex NOUN bam-1807 118 68 that that PRON bam-1807 118 69 recruits recruit VERB bam-1807 118 70 40s 40 NOUN bam-1807 118 71 ribosomal ribosomal NOUN bam-1807 118 72 subunits subunit NOUN bam-1807 118 73 to to ADP bam-1807 118 74 the the DET bam-1807 118 75 5 5 NUM bam-1807 118 76 ' ' PART bam-1807 118 77 end end NOUN bam-1807 118 78 of of ADP bam-1807 118 79 mrnas mrna NOUN bam-1807 118 80 ; ; PUNCT bam-1807 118 81 ( ( PUNCT bam-1807 118 82 iii iii X bam-1807 118 83 ) ) PUNCT bam-1807 118 84 the the DET bam-1807 118 85 phosphorylation phosphorylation NOUN bam-1807 118 86 of of ADP bam-1807 118 87 the the DET bam-1807 118 88 eukaryotic eukaryotic ADJ bam-1807 118 89 elongation elongation NOUN bam-1807 118 90 factor-2 factor-2 NUM bam-1807 118 91 kinase kinase NOUN bam-1807 118 92 ( ( PUNCT bam-1807 118 93 eef2k eef2k PROPN bam-1807 118 94 ) ) PUNCT bam-1807 118 95 , , PUNCT bam-1807 118 96 which which PRON bam-1807 118 97 relieves relieve VERB bam-1807 118 98 its its PRON bam-1807 118 99 inhibition inhibition NOUN bam-1807 118 100 on on ADP bam-1807 118 101 the the DET bam-1807 118 102 eukaryotic eukaryotic ADJ bam-1807 118 103 elongation elongation NOUN bam-1807 118 104 factor factor NOUN bam-1807 118 105 2 2 NUM bam-1807 118 106 ( ( PUNCT bam-1807 118 107 eef2 eef2 PROPN bam-1807 118 108 ) ) PUNCT bam-1807 118 109 . . PUNCT bam-1807 119 1 interestingly interestingly ADV bam-1807 119 2 , , PUNCT bam-1807 119 3 s6k1 s6k1 NOUN bam-1807 119 4 , , PUNCT bam-1807 119 5 one one NUM bam-1807 119 6 of of ADP bam-1807 119 7 the the DET bam-1807 119 8 p70 p70 PROPN bam-1807 119 9 kinases kinase NOUN bam-1807 119 10 , , PUNCT bam-1807 119 11 is be AUX bam-1807 119 12 also also ADV bam-1807 119 13 involved involve VERB bam-1807 119 14 in in ADP bam-1807 119 15 the the DET bam-1807 119 16 negative negative ADJ bam-1807 119 17 regulation regulation NOUN bam-1807 119 18 of of ADP bam-1807 119 19 the the DET bam-1807 119 20 igf-1 igf-1 NOUN bam-1807 119 21 pathway pathway NOUN bam-1807 119 22 , , PUNCT bam-1807 119 23 thus thus ADV bam-1807 119 24 limiting limit VERB bam-1807 119 25 tor tor NOUN bam-1807 119 26 signaling signal VERB bam-1807 119 27 by by ADP bam-1807 119 28 a a DET bam-1807 119 29 negative negative ADJ bam-1807 119 30 feedback feedback NOUN bam-1807 119 31 loop loop NOUN bam-1807 119 32 . . PUNCT bam-1807 120 1 as as SCONJ bam-1807 120 2 we we PRON bam-1807 120 3 have have AUX bam-1807 120 4 already already ADV bam-1807 120 5 seen see VERB bam-1807 120 6 , , PUNCT bam-1807 120 7 mtor mtor PROPN bam-1807 120 8 function function NOUN bam-1807 120 9 is be AUX bam-1807 120 10 also also ADV bam-1807 120 11 inhibited inhibit VERB bam-1807 120 12 by by ADP bam-1807 120 13 energy energy NOUN bam-1807 120 14 stress stress NOUN bam-1807 120 15 ( ( PUNCT bam-1807 120 16 via via ADP bam-1807 120 17 ampk ampk NOUN bam-1807 120 18 - - PUNCT bam-1807 120 19 dependent dependent ADJ bam-1807 120 20 regulation regulation NOUN bam-1807 120 21 ) ) PUNCT bam-1807 120 22 ; ; PUNCT bam-1807 120 23 also also ADV bam-1807 120 24 rtp801 rtp801 PROPN bam-1807 120 25 / / SYM bam-1807 120 26 redd1 redd1 NOUN bam-1807 120 27 and and CCONJ bam-1807 120 28 rtp801l rtp801l NOUN bam-1807 120 29 / / SYM bam-1807 120 30 redd2 redd2 NOUN bam-1807 120 31 , , PUNCT bam-1807 120 32 two two NUM bam-1807 120 33 hypoxia hypoxia NOUN bam-1807 120 34 - - PUNCT bam-1807 120 35 induced induce VERB bam-1807 120 36 proteins protein NOUN bam-1807 120 37 , , PUNCT bam-1807 120 38 negatively negatively ADV bam-1807 120 39 regulate regulate VERB bam-1807 120 40 mtor mtor NOUN bam-1807 120 41 activity activity NOUN bam-1807 120 42 , , PUNCT bam-1807 120 43 by by ADP bam-1807 120 44 acting act VERB bam-1807 120 45 on on ADP bam-1807 120 46 tor tor NOUN bam-1807 120 47 inbitor inbitor NOUN bam-1807 120 48 tsc2 tsc2 PROPN bam-1807 120 49 , , PUNCT bam-1807 120 50 the the DET bam-1807 120 51 exercised exercise VERB bam-1807 120 52 skeletal skeletal ADJ bam-1807 120 53 muscle muscle NOUN bam-1807 120 54 european european PROPN bam-1807 120 55 journal journal PROPN bam-1807 120 56 translational translational ADJ bam-1807 120 57 myology myology NOUN bam-1807 120 58 myology myology NOUN bam-1807 120 59 reviews review VERB bam-1807 120 60 20 20 NUM bam-1807 120 61 ( ( PUNCT bam-1807 120 62 3 3 NUM bam-1807 120 63 ): ): PUNCT bam-1807 120 64 105 105 NUM bam-1807 120 65 - - SYM bam-1807 120 66 120 120 NUM bam-1807 120 67 , , PUNCT bam-1807 120 68 2010 2010 NUM bam-1807 120 69 109 109 NUM bam-1807 120 70 however however ADV bam-1807 120 71 the the DET bam-1807 120 72 details detail NOUN bam-1807 120 73 of of ADP bam-1807 120 74 the the DET bam-1807 120 75 underlying underlying ADJ bam-1807 120 76 mechanisms mechanism NOUN bam-1807 120 77 are be AUX bam-1807 120 78 still still ADV bam-1807 120 79 unclear unclear ADJ bam-1807 120 80 [ [ X bam-1807 120 81 30 30 NUM bam-1807 120 82 ] ] PUNCT bam-1807 120 83 . . PUNCT bam-1807 121 1 one one NUM bam-1807 121 2 relevant relevant ADJ bam-1807 121 3 pathway pathway NOUN bam-1807 121 4 that that PRON bam-1807 121 5 should should AUX bam-1807 121 6 be be AUX bam-1807 121 7 considered consider VERB bam-1807 121 8 in in ADP bam-1807 121 9 the the DET bam-1807 121 10 regulation regulation NOUN bam-1807 121 11 of of ADP bam-1807 121 12 muscle muscle NOUN bam-1807 121 13 fiber fiber NOUN bam-1807 121 14 hypertrophy hypertrophy NOUN bam-1807 121 15 is be AUX bam-1807 121 16 that that SCONJ bam-1807 121 17 leading lead VERB bam-1807 121 18 to to ADP bam-1807 121 19 protein protein NOUN bam-1807 121 20 degradation degradation NOUN bam-1807 121 21 that that PRON bam-1807 121 22 occurs occur VERB bam-1807 121 23 in in ADP bam-1807 121 24 a a DET bam-1807 121 25 number number NOUN bam-1807 121 26 of of ADP bam-1807 121 27 circumstances circumstance NOUN bam-1807 121 28 such such ADJ bam-1807 121 29 as as ADP bam-1807 121 30 fasting fasting NOUN bam-1807 121 31 , , PUNCT bam-1807 121 32 disuse disuse NOUN bam-1807 121 33 and and CCONJ bam-1807 121 34 denervation denervation NOUN bam-1807 121 35 . . PUNCT bam-1807 122 1 evidence evidence NOUN bam-1807 122 2 obtained obtain VERB bam-1807 122 3 by by ADP bam-1807 122 4 gene gene NOUN bam-1807 122 5 profiling profiling NOUN bam-1807 122 6 studies study NOUN bam-1807 122 7 showed show VERB bam-1807 122 8 that that SCONJ bam-1807 122 9 atrophy atrophy NOUN bam-1807 122 10 is be AUX bam-1807 122 11 an an DET bam-1807 122 12 active active ADJ bam-1807 122 13 process process NOUN bam-1807 122 14 , , PUNCT bam-1807 122 15 requiring require VERB bam-1807 122 16 transcriptional transcriptional ADJ bam-1807 122 17 regulation regulation NOUN bam-1807 122 18 [ [ X bam-1807 122 19 11 11 NUM bam-1807 122 20 , , PUNCT bam-1807 122 21 34 34 NUM bam-1807 122 22 ] ] PUNCT bam-1807 122 23 . . PUNCT bam-1807 123 1 briefly briefly NOUN bam-1807 123 2 , , PUNCT bam-1807 123 3 it it PRON bam-1807 123 4 was be AUX bam-1807 123 5 found find VERB bam-1807 123 6 that that SCONJ bam-1807 123 7 atrophy atrophy NOUN bam-1807 123 8 signaling signal VERB bam-1807 123 9 acted act VERB bam-1807 123 10 through through ADP bam-1807 123 11 the the DET bam-1807 123 12 induction induction NOUN bam-1807 123 13 of of ADP bam-1807 123 14 two two NUM bam-1807 123 15 novel novel ADJ bam-1807 123 16 muscle muscle NOUN bam-1807 123 17 - - PUNCT bam-1807 123 18 specific specific ADJ bam-1807 123 19 ubiquitinligases ubiquitinligase NOUN bam-1807 123 20 , , PUNCT bam-1807 123 21 atrogin-1 atrogin-1 PROPN bam-1807 123 22 / / SYM bam-1807 123 23 mafbx mafbx NOUN bam-1807 123 24 and and CCONJ bam-1807 123 25 murf1 murf1 NOUN bam-1807 123 26 . . PUNCT bam-1807 124 1 although although SCONJ bam-1807 124 2 discussing discuss VERB bam-1807 124 3 the the DET bam-1807 124 4 atrophy atrophy NOUN bam-1807 124 5 pathway pathway NOUN bam-1807 124 6 goes go VERB bam-1807 124 7 beyond beyond ADP bam-1807 124 8 the the DET bam-1807 124 9 scope scope NOUN bam-1807 124 10 of of ADP bam-1807 124 11 this this DET bam-1807 124 12 review review NOUN bam-1807 124 13 , , PUNCT bam-1807 124 14 we we PRON bam-1807 124 15 wish wish VERB bam-1807 124 16 to to PART bam-1807 124 17 point point VERB bam-1807 124 18 out out ADP bam-1807 124 19 the the DET bam-1807 124 20 cross cross ADJ bam-1807 124 21 - - ADJ bam-1807 124 22 talk talk ADJ bam-1807 124 23 connecting connect VERB bam-1807 124 24 the the DET bam-1807 124 25 hypertrophy hypertrophy NOUN bam-1807 124 26 with with ADP bam-1807 124 27 the the DET bam-1807 124 28 atrophy atrophy NOUN bam-1807 124 29 pathways pathway NOUN bam-1807 124 30 . . PUNCT bam-1807 125 1 in in ADP bam-1807 125 2 fact fact NOUN bam-1807 125 3 , , PUNCT bam-1807 125 4 it it PRON bam-1807 125 5 was be AUX bam-1807 125 6 found find VERB bam-1807 125 7 that that SCONJ bam-1807 125 8 igf1 igf1 PROPN bam-1807 125 9 - - PUNCT bam-1807 125 10 akt akt PROPN bam-1807 125 11 signaling signal VERB bam-1807 125 12 is be AUX bam-1807 125 13 able able ADJ bam-1807 125 14 to to PART bam-1807 125 15 block block VERB bam-1807 125 16 disuse disuse NOUN bam-1807 125 17 atrophy atrophy NOUN bam-1807 125 18 . . PUNCT bam-1807 126 1 when when SCONJ bam-1807 126 2 the the DET bam-1807 126 3 transcription transcription NOUN bam-1807 126 4 factors factor NOUN bam-1807 126 5 of of ADP bam-1807 126 6 the the DET bam-1807 126 7 foxo foxo ADJ bam-1807 126 8 family family NOUN bam-1807 126 9 are be AUX bam-1807 126 10 phosphorylated phosphorylate VERB bam-1807 126 11 by by ADP bam-1807 126 12 akt akt PROPN bam-1807 126 13 , , PUNCT bam-1807 126 14 they they PRON bam-1807 126 15 are be AUX bam-1807 126 16 exported export VERB bam-1807 126 17 from from ADP bam-1807 126 18 the the DET bam-1807 126 19 nucleus nucleus NOUN bam-1807 126 20 to to ADP bam-1807 126 21 the the DET bam-1807 126 22 cytoplasm cytoplasm NOUN bam-1807 126 23 ; ; PUNCT bam-1807 126 24 it it PRON bam-1807 126 25 was be AUX bam-1807 126 26 found find VERB bam-1807 126 27 , , PUNCT bam-1807 126 28 in in ADP bam-1807 126 29 particular particular ADJ bam-1807 126 30 , , PUNCT bam-1807 126 31 that that SCONJ bam-1807 126 32 foxo3 foxo3 PROPN bam-1807 126 33 induces induce VERB bam-1807 126 34 atrogin1 atrogin1 NOUN bam-1807 126 35 / / SYM bam-1807 126 36 mafbx mafbx NOUN bam-1807 126 37 transcription transcription NOUN bam-1807 126 38 [ [ X bam-1807 126 39 97 97 NUM bam-1807 126 40 ] ] PUNCT bam-1807 126 41 . . PUNCT bam-1807 127 1 in in ADP bam-1807 127 2 addition addition NOUN bam-1807 127 3 , , PUNCT bam-1807 127 4 foxo foxo NOUN bam-1807 127 5 upregulates upregulate VERB bam-1807 127 6 4ebp1 4ebp1 PRON bam-1807 127 7 and and CCONJ bam-1807 127 8 downregulates downregulate VERB bam-1807 127 9 raptor raptor NOUN bam-1807 127 10 and and CCONJ bam-1807 127 11 mtor mtor NOUN bam-1807 127 12 . . PUNCT bam-1807 128 1 thus thus ADV bam-1807 128 2 , , PUNCT bam-1807 128 3 protein protein NOUN bam-1807 128 4 breakdown breakdown NOUN bam-1807 128 5 is be AUX bam-1807 128 6 activated activate VERB bam-1807 128 7 concurrently concurrently ADV bam-1807 128 8 with with ADP bam-1807 128 9 protein protein NOUN bam-1807 128 10 synthesis synthesis NOUN bam-1807 128 11 inhibition inhibition NOUN bam-1807 128 12 , , PUNCT bam-1807 128 13 and and CCONJ bam-1807 128 14 viceversa viceversa NOUN bam-1807 128 15 . . PUNCT bam-1807 129 1 also also ADV bam-1807 129 2 inflammatory inflammatory ADJ bam-1807 129 3 cytokines cytokine NOUN bam-1807 129 4 , , PUNCT bam-1807 129 5 such such ADJ bam-1807 129 6 as as ADP bam-1807 129 7 tnfα tnfα NOUN bam-1807 129 8 , , PUNCT bam-1807 129 9 are be AUX bam-1807 129 10 able able ADJ bam-1807 129 11 to to PART bam-1807 129 12 induce induce VERB bam-1807 129 13 protein protein NOUN bam-1807 129 14 breakdown breakdown NOUN bam-1807 129 15 through through ADP bam-1807 129 16 the the DET bam-1807 129 17 upregulation upregulation NOUN bam-1807 129 18 of of ADP bam-1807 129 19 murf1 murf1 PROPN bam-1807 129 20 , , PUNCT bam-1807 129 21 and and CCONJ bam-1807 129 22 at at ADP bam-1807 129 23 the the DET bam-1807 129 24 same same ADJ bam-1807 129 25 time time NOUN bam-1807 129 26 they they PRON bam-1807 129 27 inhibit inhibit VERB bam-1807 129 28 pi3k pi3k PROPN bam-1807 129 29 - - PUNCT bam-1807 129 30 akt akt NOUN bam-1807 129 31 signaling signal VERB bam-1807 129 32 . . PUNCT bam-1807 130 1 all all DET bam-1807 130 2 the the DET bam-1807 130 3 major major ADJ bam-1807 130 4 catabolic catabolic ADJ bam-1807 130 5 pathways pathway NOUN bam-1807 130 6 are be AUX bam-1807 130 7 in in ADP bam-1807 130 8 fact fact NOUN bam-1807 130 9 negatively negatively ADV bam-1807 130 10 controlled control VERB bam-1807 130 11 by by ADP bam-1807 130 12 active active ADJ bam-1807 130 13 mtor mtor NOUN bam-1807 130 14 . . PUNCT bam-1807 131 1 in in ADP bam-1807 131 2 fact fact NOUN bam-1807 131 3 , , PUNCT bam-1807 131 4 mtor mtor PROPN bam-1807 131 5 is be AUX bam-1807 131 6 also also ADV bam-1807 131 7 involved involve VERB bam-1807 131 8 in in ADP bam-1807 131 9 the the DET bam-1807 131 10 regulation regulation NOUN bam-1807 131 11 of of ADP bam-1807 131 12 the the DET bam-1807 131 13 autophagy autophagy ADJ bam-1807 131 14 / / SYM bam-1807 131 15 lysosome lysosome NOUN bam-1807 131 16 pathway pathway NOUN bam-1807 131 17 and and CCONJ bam-1807 131 18 of of ADP bam-1807 131 19 apoptosis apoptosis NOUN bam-1807 131 20 . . PUNCT bam-1807 132 1 an an DET bam-1807 132 2 excellent excellent ADJ bam-1807 132 3 discussion discussion NOUN bam-1807 132 4 of of ADP bam-1807 132 5 the the DET bam-1807 132 6 interconnections interconnection NOUN bam-1807 132 7 between between ADP bam-1807 132 8 the the DET bam-1807 132 9 hypertrophy hypertrophy NOUN bam-1807 132 10 and and CCONJ bam-1807 132 11 the the DET bam-1807 132 12 atrophy atrophy NOUN bam-1807 132 13 pathways pathway NOUN bam-1807 132 14 can can AUX bam-1807 132 15 be be AUX bam-1807 132 16 found find VERB bam-1807 132 17 in in ADP bam-1807 132 18 a a DET bam-1807 132 19 recent recent ADJ bam-1807 132 20 review review NOUN bam-1807 132 21 [ [ X bam-1807 132 22 98 98 NUM bam-1807 132 23 ] ] PUNCT bam-1807 132 24 . . PUNCT bam-1807 133 1 in in ADP bam-1807 133 2 the the DET bam-1807 133 3 multinucleated multinucleate VERB bam-1807 133 4 muscle muscle NOUN bam-1807 133 5 fiber fiber NOUN bam-1807 133 6 , , PUNCT bam-1807 133 7 each each DET bam-1807 133 8 myonucleus myonucleus NOUN bam-1807 133 9 is be AUX bam-1807 133 10 known know VERB bam-1807 133 11 to to PART bam-1807 133 12 control control VERB bam-1807 133 13 gene gene NOUN bam-1807 133 14 transcription transcription NOUN bam-1807 133 15 and and CCONJ bam-1807 133 16 the the DET bam-1807 133 17 subsequent subsequent ADJ bam-1807 133 18 translation translation NOUN bam-1807 133 19 over over ADP bam-1807 133 20 a a DET bam-1807 133 21 definite definite ADJ bam-1807 133 22 cytoplasm cytoplasm NOUN bam-1807 133 23 volume volume NOUN bam-1807 133 24 [ [ X bam-1807 133 25 16 16 NUM bam-1807 133 26 ] ] PUNCT bam-1807 133 27 . . PUNCT bam-1807 134 1 therefore therefore ADV bam-1807 134 2 , , PUNCT bam-1807 134 3 all all PRON bam-1807 134 4 stimuli stimulus NOUN bam-1807 134 5 that that PRON bam-1807 134 6 determine determine VERB bam-1807 134 7 an an DET bam-1807 134 8 increase increase NOUN bam-1807 134 9 in in ADP bam-1807 134 10 the the DET bam-1807 134 11 fiber fiber NOUN bam-1807 134 12 cytoplasmic cytoplasmic ADJ bam-1807 134 13 mass mass NOUN bam-1807 134 14 are be AUX bam-1807 134 15 likely likely ADJ bam-1807 134 16 to to PART bam-1807 134 17 induce induce VERB bam-1807 134 18 myonuclear myonuclear NOUN bam-1807 134 19 addition addition NOUN bam-1807 134 20 by by ADP bam-1807 134 21 satellite satellite NOUN bam-1807 134 22 cell cell NOUN bam-1807 134 23 proliferation proliferation NOUN bam-1807 134 24 and and CCONJ bam-1807 134 25 fusion fusion NOUN bam-1807 134 26 to to ADP bam-1807 134 27 existing exist VERB bam-1807 134 28 fibers fiber NOUN bam-1807 134 29 [ [ X bam-1807 134 30 78 78 NUM bam-1807 134 31 ] ] PUNCT bam-1807 134 32 . . PUNCT bam-1807 135 1 bearing bear VERB bam-1807 135 2 in in ADP bam-1807 135 3 mind mind NOUN bam-1807 135 4 that that SCONJ bam-1807 135 5 c c X bam-1807 135 6 - - PUNCT bam-1807 135 7 fos fos NOUN bam-1807 135 8 is be AUX bam-1807 135 9 expressed express VERB bam-1807 135 10 at at ADP bam-1807 135 11 the the DET bam-1807 135 12 onset onset NOUN bam-1807 135 13 of of ADP bam-1807 135 14 a a DET bam-1807 135 15 mitogenic mitogenic ADJ bam-1807 135 16 signaling signal VERB bam-1807 135 17 cascade cascade NOUN bam-1807 135 18 , , PUNCT bam-1807 135 19 it it PRON bam-1807 135 20 is be AUX bam-1807 135 21 noteworthy noteworthy ADJ bam-1807 135 22 that that SCONJ bam-1807 135 23 a a DET bam-1807 135 24 single single ADJ bam-1807 135 25 bout bout NOUN bam-1807 135 26 of of ADP bam-1807 135 27 exercise exercise NOUN bam-1807 135 28 is be AUX bam-1807 135 29 sufficient sufficient ADJ bam-1807 135 30 to to PART bam-1807 135 31 stimulate stimulate VERB bam-1807 135 32 a a DET bam-1807 135 33 more more ADJ bam-1807 135 34 than than ADP bam-1807 135 35 20 20 NUM bam-1807 135 36 - - ADJ bam-1807 135 37 fold fold ADJ bam-1807 135 38 increase increase NOUN bam-1807 135 39 in in ADP bam-1807 135 40 c c NOUN bam-1807 135 41 - - PUNCT bam-1807 135 42 fos fos NOUN bam-1807 135 43 mrna mrna NOUN bam-1807 135 44 within within ADP bam-1807 135 45 4 4 NUM bam-1807 135 46 minutes minute NOUN bam-1807 135 47 [ [ X bam-1807 135 48 14 14 NUM bam-1807 135 49 ] ] X bam-1807 135 50 ; ; PUNCT bam-1807 135 51 this this PRON bam-1807 135 52 suggests suggest VERB bam-1807 135 53 that that PRON bam-1807 135 54 exercise exercise VERB bam-1807 135 55 itself itself PRON bam-1807 135 56 , , PUNCT bam-1807 135 57 rather rather ADV bam-1807 135 58 than than ADP bam-1807 135 59 the the DET bam-1807 135 60 need need NOUN bam-1807 135 61 of of ADP bam-1807 135 62 repairing repair VERB bam-1807 135 63 microtraumas microtrauma NOUN bam-1807 135 64 , , PUNCT bam-1807 135 65 is be AUX bam-1807 135 66 the the DET bam-1807 135 67 initiating initiate VERB bam-1807 135 68 stimulus stimulus NOUN bam-1807 135 69 for for ADP bam-1807 135 70 satellite satellite NOUN bam-1807 135 71 cell cell NOUN bam-1807 135 72 proliferation proliferation NOUN bam-1807 135 73 . . PUNCT bam-1807 136 1 however however ADV bam-1807 136 2 , , PUNCT bam-1807 136 3 mechanisms mechanism NOUN bam-1807 136 4 by by ADP bam-1807 136 5 which which PRON bam-1807 136 6 the the DET bam-1807 136 7 mechanical mechanical ADJ bam-1807 136 8 stimuli stimulus NOUN bam-1807 136 9 of of ADP bam-1807 136 10 exercise exercise NOUN bam-1807 136 11 are be AUX bam-1807 136 12 transduced transduce VERB bam-1807 136 13 into into ADP bam-1807 136 14 satellite satellite NOUN bam-1807 136 15 cell cell NOUN bam-1807 136 16 activation activation NOUN bam-1807 136 17 are be AUX bam-1807 136 18 still still ADV bam-1807 136 19 poorly poorly ADV bam-1807 136 20 understood understand VERB bam-1807 136 21 . . PUNCT bam-1807 137 1 on on ADP bam-1807 137 2 the the DET bam-1807 137 3 other other ADJ bam-1807 137 4 hand hand NOUN bam-1807 137 5 , , PUNCT bam-1807 137 6 the the DET bam-1807 137 7 endocrine endocrine ADJ bam-1807 137 8 context context NOUN bam-1807 137 9 for for ADP bam-1807 137 10 satellite satellite NOUN bam-1807 137 11 cell cell NOUN bam-1807 137 12 activation activation NOUN bam-1807 137 13 and and CCONJ bam-1807 137 14 quiescence quiescence NOUN bam-1807 137 15 and and CCONJ bam-1807 137 16 the the DET bam-1807 137 17 signaling signal VERB bam-1807 137 18 pathways pathway NOUN bam-1807 137 19 thus thus ADV bam-1807 137 20 controlled control VERB bam-1807 137 21 are be AUX bam-1807 137 22 better well ADV bam-1807 137 23 understood understand VERB bam-1807 137 24 [ [ X bam-1807 137 25 82 82 NUM bam-1807 137 26 , , PUNCT bam-1807 137 27 108 108 NUM bam-1807 137 28 , , PUNCT bam-1807 137 29 119 119 NUM bam-1807 137 30 ] ] PUNCT bam-1807 137 31 . . PUNCT bam-1807 138 1 the the DET bam-1807 138 2 stimulating stimulating ADJ bam-1807 138 3 effect effect NOUN bam-1807 138 4 of of ADP bam-1807 138 5 anabolic anabolic NOUN bam-1807 138 6 factors factor NOUN bam-1807 138 7 such such ADJ bam-1807 138 8 as as ADP bam-1807 138 9 nutritional nutritional ADJ bam-1807 138 10 state state NOUN bam-1807 138 11 , , PUNCT bam-1807 138 12 androgens androgen NOUN bam-1807 138 13 , , PUNCT bam-1807 138 14 growth growth NOUN bam-1807 138 15 hormone hormone NOUN bam-1807 138 16 , , PUNCT bam-1807 138 17 insulin insulin NOUN bam-1807 138 18 , , PUNCT bam-1807 138 19 vitamin vitamin NOUN bam-1807 138 20 d d NOUN bam-1807 138 21 , , PUNCT bam-1807 138 22 and and CCONJ bam-1807 138 23 pathways pathway NOUN bam-1807 138 24 requiring require VERB bam-1807 138 25 nitric nitric ADJ bam-1807 138 26 oxide oxide NOUN bam-1807 138 27 release release NOUN bam-1807 138 28 and and CCONJ bam-1807 138 29 hepatocyte hepatocyte NOUN bam-1807 138 30 growth growth NOUN bam-1807 138 31 factor factor NOUN bam-1807 138 32 - - PUNCT bam-1807 138 33 c c NOUN bam-1807 138 34 - - PUNCT bam-1807 138 35 met meet VERB bam-1807 138 36 interaction interaction NOUN bam-1807 138 37 have have AUX bam-1807 138 38 been be AUX bam-1807 138 39 acknowledged acknowledge VERB bam-1807 138 40 . . PUNCT bam-1807 139 1 on on ADP bam-1807 139 2 the the DET bam-1807 139 3 other other ADJ bam-1807 139 4 hand hand NOUN bam-1807 139 5 , , PUNCT bam-1807 139 6 satellite satellite NOUN bam-1807 139 7 cell cell NOUN bam-1807 139 8 activation activation NOUN bam-1807 139 9 and and CCONJ bam-1807 139 10 proliferation proliferation NOUN bam-1807 139 11 is be AUX bam-1807 139 12 negatively negatively ADV bam-1807 139 13 controlled control VERB bam-1807 139 14 by by ADP bam-1807 139 15 the the DET bam-1807 139 16 myostatin myostatin PROPN bam-1807 139 17 - - PUNCT bam-1807 139 18 smad smad ADJ bam-1807 139 19 signaling signal VERB bam-1807 139 20 pathway pathway NOUN bam-1807 139 21 . . PUNCT bam-1807 140 1 mutations mutation NOUN bam-1807 140 2 of of ADP bam-1807 140 3 the the DET bam-1807 140 4 myostatin myostatin ADJ bam-1807 140 5 gene gene NOUN bam-1807 140 6 lead lead NOUN bam-1807 140 7 to to ADP bam-1807 140 8 a a DET bam-1807 140 9 phenotype phenotype NOUN bam-1807 140 10 of of ADP bam-1807 140 11 exaggerated exaggerated ADJ bam-1807 140 12 muscle muscle NOUN bam-1807 140 13 hypertrophy hypertrophy NOUN bam-1807 140 14 , , PUNCT bam-1807 140 15 also also ADV bam-1807 140 16 described describe VERB bam-1807 140 17 in in ADP bam-1807 140 18 one one NUM bam-1807 140 19 human human ADJ bam-1807 140 20 child child NOUN bam-1807 140 21 [ [ X bam-1807 140 22 103 103 NUM bam-1807 140 23 ] ] PUNCT bam-1807 140 24 . . PUNCT bam-1807 141 1 myostatin myostatin PROPN bam-1807 141 2 is be AUX bam-1807 141 3 a a DET bam-1807 141 4 member member NOUN bam-1807 141 5 of of ADP bam-1807 141 6 the the DET bam-1807 141 7 tgf tgf PROPN bam-1807 141 8 superfamily superfamily NOUN bam-1807 141 9 ; ; PUNCT bam-1807 141 10 it it PRON bam-1807 141 11 binds bind VERB bam-1807 141 12 to to ADP bam-1807 141 13 activin activin PROPN bam-1807 141 14 type type NOUN bam-1807 141 15 i i PROPN bam-1807 141 16 receptors receptor NOUN bam-1807 141 17 and and CCONJ bam-1807 141 18 acts act VERB bam-1807 141 19 as as ADP bam-1807 141 20 an an DET bam-1807 141 21 inhibitor inhibitor NOUN bam-1807 141 22 of of ADP bam-1807 141 23 muscle muscle NOUN bam-1807 141 24 growth growth NOUN bam-1807 141 25 , , PUNCT bam-1807 141 26 by by ADP bam-1807 141 27 affecting affect VERB bam-1807 141 28 the the DET bam-1807 141 29 entry entry NOUN bam-1807 141 30 of of ADP bam-1807 141 31 satellite satellite NOUN bam-1807 141 32 cells cell NOUN bam-1807 141 33 into into ADP bam-1807 141 34 s s NOUN bam-1807 141 35 - - NOUN bam-1807 141 36 phase phase NOUN bam-1807 141 37 . . PUNCT bam-1807 142 1 myostatin myostatin PROPN bam-1807 142 2 gene gene NOUN bam-1807 142 3 is be AUX bam-1807 142 4 upregulated upregulate VERB bam-1807 142 5 by by ADP bam-1807 142 6 glucocorticoids glucocorticoid NOUN bam-1807 142 7 and and CCONJ bam-1807 142 8 its its PRON bam-1807 142 9 expression expression NOUN bam-1807 142 10 is be AUX bam-1807 142 11 negatively negatively ADV bam-1807 142 12 controlled control VERB bam-1807 142 13 by by ADP bam-1807 142 14 exercise exercise NOUN bam-1807 142 15 , , PUNCT bam-1807 142 16 growth growth NOUN bam-1807 142 17 hormone hormone NOUN bam-1807 142 18 and and CCONJ bam-1807 142 19 anabolic anabolic NOUN bam-1807 142 20 stimuli stimulus NOUN bam-1807 142 21 . . PUNCT bam-1807 143 1 a a DET bam-1807 143 2 variety variety NOUN bam-1807 143 3 of of ADP bam-1807 143 4 conditions condition NOUN bam-1807 143 5 causing cause VERB bam-1807 143 6 muscle muscle NOUN bam-1807 143 7 loss loss NOUN bam-1807 143 8 are be AUX bam-1807 143 9 associated associate VERB bam-1807 143 10 with with ADP bam-1807 143 11 observable observable ADJ bam-1807 143 12 increase increase NOUN bam-1807 143 13 in in ADP bam-1807 143 14 myostatin myostatin ADJ bam-1807 143 15 levels level NOUN bam-1807 143 16 , , PUNCT bam-1807 143 17 including include VERB bam-1807 143 18 ageing age VERB bam-1807 143 19 - - PUNCT bam-1807 143 20 associated associate VERB bam-1807 143 21 sarcopenia sarcopenia NOUN bam-1807 143 22 . . PUNCT bam-1807 144 1 4 4 X bam-1807 144 2 . . X bam-1807 144 3 metabolic metabolic NOUN bam-1807 144 4 adaptation adaptation NOUN bam-1807 144 5 to to PART bam-1807 144 6 exercise exercise VERB bam-1807 144 7 as as SCONJ bam-1807 144 8 pointed point VERB bam-1807 144 9 out out ADP bam-1807 144 10 above above ADV bam-1807 144 11 , , PUNCT bam-1807 144 12 the the DET bam-1807 144 13 energetic energetic ADJ bam-1807 144 14 characteristics characteristic NOUN bam-1807 144 15 and and CCONJ bam-1807 144 16 the the DET bam-1807 144 17 enzymatic enzymatic ADJ bam-1807 144 18 equipment equipment NOUN bam-1807 144 19 of of ADP bam-1807 144 20 muscle muscle NOUN bam-1807 144 21 fibers fiber NOUN bam-1807 144 22 are be AUX bam-1807 144 23 adapted adapt VERB bam-1807 144 24 to to ADP bam-1807 144 25 the the DET bam-1807 144 26 specific specific ADJ bam-1807 144 27 requirements requirement NOUN bam-1807 144 28 of of ADP bam-1807 144 29 a a DET bam-1807 144 30 given give VERB bam-1807 144 31 muscle muscle NOUN bam-1807 144 32 and and CCONJ bam-1807 144 33 to to ADP bam-1807 144 34 the the DET bam-1807 144 35 power power NOUN bam-1807 144 36 output output NOUN bam-1807 144 37 required require VERB bam-1807 144 38 . . PUNCT bam-1807 145 1 slow slow ADJ bam-1807 145 2 skeletal skeletal ADJ bam-1807 145 3 muscles muscle NOUN bam-1807 145 4 develop develop VERB bam-1807 145 5 lower low ADJ bam-1807 145 6 contractile contractile NOUN bam-1807 145 7 forces force NOUN bam-1807 145 8 than than ADP bam-1807 145 9 fast fast ADJ bam-1807 145 10 ones one NOUN bam-1807 145 11 , , PUNCT bam-1807 145 12 but but CCONJ bam-1807 145 13 are be AUX bam-1807 145 14 able able ADJ bam-1807 145 15 to to PART bam-1807 145 16 maintain maintain VERB bam-1807 145 17 long long ADJ bam-1807 145 18 - - PUNCT bam-1807 145 19 term term NOUN bam-1807 145 20 contractile contractile NOUN bam-1807 145 21 activity activity NOUN bam-1807 145 22 because because SCONJ bam-1807 145 23 they they PRON bam-1807 145 24 rely rely VERB bam-1807 145 25 on on ADP bam-1807 145 26 oxidative oxidative ADJ bam-1807 145 27 metabolism metabolism NOUN bam-1807 145 28 . . PUNCT bam-1807 146 1 on on ADP bam-1807 146 2 the the DET bam-1807 146 3 other other ADJ bam-1807 146 4 hand hand NOUN bam-1807 146 5 , , PUNCT bam-1807 146 6 fast fast ADJ bam-1807 146 7 skeletal skeletal ADJ bam-1807 146 8 muscle muscle NOUN bam-1807 146 9 fibers fiber NOUN bam-1807 146 10 develop develop VERB bam-1807 146 11 strong strong ADJ bam-1807 146 12 and and CCONJ bam-1807 146 13 fast fast ADJ bam-1807 146 14 contractions contraction NOUN bam-1807 146 15 but but CCONJ bam-1807 146 16 only only ADV bam-1807 146 17 for for ADP bam-1807 146 18 short short ADJ bam-1807 146 19 periods period NOUN bam-1807 146 20 of of ADP bam-1807 146 21 time time NOUN bam-1807 146 22 because because SCONJ bam-1807 146 23 they they PRON bam-1807 146 24 mainly mainly ADV bam-1807 146 25 rely rely VERB bam-1807 146 26 on on ADP bam-1807 146 27 quickly quickly ADV bam-1807 146 28 available available ADJ bam-1807 146 29 but but CCONJ bam-1807 146 30 quantitatively quantitatively ADV bam-1807 146 31 limited limited ADJ bam-1807 146 32 energy energy NOUN bam-1807 146 33 sources source NOUN bam-1807 146 34 , , PUNCT bam-1807 146 35 mainly mainly ADV bam-1807 146 36 phosphocreatine phosphocreatine NOUN bam-1807 146 37 and and CCONJ bam-1807 146 38 glycogen glycogen NOUN bam-1807 146 39 . . PUNCT bam-1807 147 1 this this PRON bam-1807 147 2 makes make VERB bam-1807 147 3 fast fast ADJ bam-1807 147 4 skeletal skeletal ADJ bam-1807 147 5 muscles muscle NOUN bam-1807 147 6 quickly quickly ADV bam-1807 147 7 fatigable fatigable VERB bam-1807 147 8 , , PUNCT bam-1807 147 9 as as SCONJ bam-1807 147 10 they they PRON bam-1807 147 11 replenish replenish VERB bam-1807 147 12 their their PRON bam-1807 147 13 energy energy NOUN bam-1807 147 14 reserves reserve NOUN bam-1807 147 15 mainly mainly ADV bam-1807 147 16 through through ADP bam-1807 147 17 anaerobic anaerobic ADJ bam-1807 147 18 glycolysis glycolysis NOUN bam-1807 147 19 . . PUNCT bam-1807 148 1 as as ADP bam-1807 148 2 a a DET bam-1807 148 3 consequence consequence NOUN bam-1807 148 4 of of ADP bam-1807 148 5 endurance endurance NOUN bam-1807 148 6 training training NOUN bam-1807 148 7 , , PUNCT bam-1807 148 8 in in ADP bam-1807 148 9 parallel parallel NOUN bam-1807 148 10 with with ADP bam-1807 148 11 the the DET bam-1807 148 12 fast fast ADJ bam-1807 148 13 - - PUNCT bam-1807 148 14 to to ADP bam-1807 148 15 - - PUNCT bam-1807 148 16 slow slow ADJ bam-1807 148 17 switch switch NOUN bam-1807 148 18 in in ADP bam-1807 148 19 mhc mhc PROPN bam-1807 148 20 isoforms isoform NOUN bam-1807 148 21 that that PRON bam-1807 148 22 has have AUX bam-1807 148 23 been be AUX bam-1807 148 24 described describe VERB bam-1807 148 25 above above ADP bam-1807 148 26 , , PUNCT bam-1807 148 27 an an DET bam-1807 148 28 increase increase NOUN bam-1807 148 29 in in ADP bam-1807 148 30 skeletal skeletal ADJ bam-1807 148 31 muscle muscle NOUN bam-1807 148 32 oxidative oxidative ADJ bam-1807 148 33 capacity capacity NOUN bam-1807 148 34 is be AUX bam-1807 148 35 observed observe VERB bam-1807 148 36 . . PUNCT bam-1807 149 1 such such ADJ bam-1807 149 2 metabolic metabolic NOUN bam-1807 149 3 adaptation adaptation NOUN bam-1807 149 4 is be AUX bam-1807 149 5 the the DET bam-1807 149 6 result result NOUN bam-1807 149 7 of of ADP bam-1807 149 8 biochemical biochemical ADJ bam-1807 149 9 cascades cascade NOUN bam-1807 149 10 that that PRON bam-1807 149 11 influence influence NOUN bam-1807 149 12 gene gene NOUN bam-1807 149 13 expression expression NOUN bam-1807 149 14 and and CCONJ bam-1807 149 15 that that PRON bam-1807 149 16 are be AUX bam-1807 149 17 triggered trigger VERB bam-1807 149 18 by by ADP bam-1807 149 19 changes change NOUN bam-1807 149 20 in in ADP bam-1807 149 21 intramuscular intramuscular ADJ bam-1807 149 22 calcium calcium NOUN bam-1807 149 23 levels level NOUN bam-1807 149 24 , , PUNCT bam-1807 149 25 energy energy NOUN bam-1807 149 26 availability availability NOUN bam-1807 149 27 , , PUNCT bam-1807 149 28 plasma plasma NOUN bam-1807 149 29 concentration concentration NOUN bam-1807 149 30 of of ADP bam-1807 149 31 free free ADJ bam-1807 149 32 fatty fatty NOUN bam-1807 149 33 acids acid NOUN bam-1807 149 34 , , PUNCT bam-1807 149 35 mechanical mechanical ADJ bam-1807 149 36 stress stress NOUN bam-1807 149 37 and and CCONJ bam-1807 149 38 local local ADJ bam-1807 149 39 hypoxia hypoxia NOUN bam-1807 149 40 . . PUNCT bam-1807 150 1 the the DET bam-1807 150 2 increase increase NOUN bam-1807 150 3 in in ADP bam-1807 150 4 muscle muscle NOUN bam-1807 150 5 oxidative oxidative ADJ bam-1807 150 6 capacity capacity NOUN bam-1807 150 7 involves involve VERB bam-1807 150 8 multiple multiple ADJ bam-1807 150 9 pathways pathway NOUN bam-1807 150 10 and and CCONJ bam-1807 150 11 is be AUX bam-1807 150 12 achieved achieve VERB bam-1807 150 13 by by ADP bam-1807 150 14 more more ADJ bam-1807 150 15 sustained sustained ADJ bam-1807 150 16 fatty fatty NOUN bam-1807 150 17 acid acid NOUN bam-1807 150 18 utilization utilization NOUN bam-1807 150 19 , , PUNCT bam-1807 150 20 mitochondrial mitochondrial ADJ bam-1807 150 21 biogenesis biogenesis NOUN bam-1807 150 22 and and CCONJ bam-1807 150 23 higher high ADJ bam-1807 150 24 levels level NOUN bam-1807 150 25 of of ADP bam-1807 150 26 the the DET bam-1807 150 27 oxidative oxidative ADJ bam-1807 150 28 metabolism metabolism NOUN bam-1807 150 29 enzymes enzyme NOUN bam-1807 150 30 , , PUNCT bam-1807 150 31 improved improve VERB bam-1807 150 32 glucose glucose NOUN bam-1807 150 33 transport transport NOUN bam-1807 150 34 and and CCONJ bam-1807 150 35 neo neo NOUN bam-1807 150 36 - - NOUN bam-1807 150 37 angiogenesis angiogenesis NOUN bam-1807 150 38 . . PUNCT bam-1807 151 1 enhanced enhance VERB bam-1807 151 2 lipid lipid NOUN bam-1807 151 3 utilization utilization NOUN bam-1807 151 4 during during ADP bam-1807 151 5 exercise exercise NOUN bam-1807 151 6 at at ADP bam-1807 151 7 moderate moderate ADJ bam-1807 151 8 intensity intensity NOUN bam-1807 151 9 in in ADP bam-1807 151 10 muscles muscle NOUN bam-1807 151 11 of of ADP bam-1807 151 12 endurance endurance NOUN bam-1807 151 13 - - PUNCT bam-1807 151 14 trained train VERB bam-1807 151 15 subjects subject NOUN bam-1807 151 16 has have AUX bam-1807 151 17 been be AUX bam-1807 151 18 observed observe VERB bam-1807 151 19 , , PUNCT bam-1807 151 20 with with ADP bam-1807 151 21 a a DET bam-1807 151 22 selective selective ADJ bam-1807 151 23 increase increase NOUN bam-1807 151 24 in in ADP bam-1807 151 25 mrna mrna PROPN bam-1807 151 26 levels level NOUN bam-1807 151 27 of of ADP bam-1807 151 28 enzymes enzyme NOUN bam-1807 151 29 involved involve VERB bam-1807 151 30 in in ADP bam-1807 151 31 metabolization metabolization NOUN bam-1807 151 32 of of ADP bam-1807 151 33 intramuscular intramuscular ADJ bam-1807 151 34 fatty fatty ADJ bam-1807 151 35 acids acid NOUN bam-1807 152 1 [ [ X bam-1807 152 2 101 101 NUM bam-1807 152 3 ] ] PUNCT bam-1807 152 4 and and CCONJ bam-1807 152 5 in in ADP bam-1807 152 6 their their PRON bam-1807 152 7 oxidation oxidation NOUN bam-1807 152 8 . . PUNCT bam-1807 153 1 in in ADP bam-1807 153 2 particular particular ADJ bam-1807 153 3 , , PUNCT bam-1807 153 4 in in ADP bam-1807 153 5 endurance endurance NOUN bam-1807 153 6 athletes athlete NOUN bam-1807 153 7 , , PUNCT bam-1807 153 8 it it PRON bam-1807 153 9 has have AUX bam-1807 153 10 been be AUX bam-1807 153 11 reported report VERB bam-1807 153 12 that that SCONJ bam-1807 153 13 skeletal skeletal ADJ bam-1807 153 14 muscle muscle NOUN bam-1807 153 15 content content NOUN bam-1807 153 16 of of ADP bam-1807 153 17 mdac mdac PROPN bam-1807 153 18 and and CCONJ bam-1807 153 19 vldac vldac NOUN bam-1807 153 20 ( ( PUNCT bam-1807 153 21 medium medium NOUN bam-1807 153 22 and and CCONJ bam-1807 153 23 very very ADV bam-1807 153 24 long long ADJ bam-1807 153 25 chain chain NOUN bam-1807 153 26 - - PUNCT bam-1807 153 27 specific specific ADJ bam-1807 153 28 acyl acyl NOUN bam-1807 153 29 - - PUNCT bam-1807 153 30 coa coa NOUN bam-1807 153 31 dehydrogenases dehydrogenase NOUN bam-1807 153 32 ) ) PUNCT bam-1807 153 33 , , PUNCT bam-1807 153 34 involved involve VERB bam-1807 153 35 in in ADP bam-1807 153 36 beta beta ADJ bam-1807 153 37 oxidation oxidation NOUN bam-1807 153 38 of of ADP bam-1807 153 39 fatty fatty NOUN bam-1807 153 40 acids acid NOUN bam-1807 153 41 , , PUNCT bam-1807 153 42 and and CCONJ bam-1807 153 43 of of ADP bam-1807 153 44 peroxisome peroxisome VERB bam-1807 153 45 proliferator proliferator NOUN bam-1807 153 46 - - PUNCT bam-1807 153 47 activated activate VERB bam-1807 153 48 receptor receptor NOUN bam-1807 153 49 - - PUNCT bam-1807 153 50 alpha alpha NOUN bam-1807 153 51 ( ( PUNCT bam-1807 153 52 pparα pparα NOUN bam-1807 153 53 ) ) PUNCT bam-1807 153 54 doubled double VERB bam-1807 153 55 , , PUNCT bam-1807 153 56 despite despite SCONJ bam-1807 153 57 a a DET bam-1807 153 58 limited limited ADJ bam-1807 153 59 increase increase NOUN bam-1807 153 60 in in ADP bam-1807 153 61 whole whole ADJ bam-1807 153 62 body body NOUN bam-1807 153 63 and and CCONJ bam-1807 153 64 plasma plasma NOUN bam-1807 153 65 fatty fatty NOUN bam-1807 153 66 acid acid NOUN bam-1807 153 67 oxidation oxidation NOUN bam-1807 154 1 [ [ X bam-1807 154 2 43 43 NUM bam-1807 154 3 ] ] PUNCT bam-1807 154 4 . . PUNCT bam-1807 155 1 more more ADV bam-1807 155 2 recently recently ADV bam-1807 155 3 , , PUNCT bam-1807 155 4 it it PRON bam-1807 155 5 has have AUX bam-1807 155 6 been be AUX bam-1807 155 7 reported report VERB bam-1807 155 8 that that SCONJ bam-1807 155 9 the the DET bam-1807 155 10 exercised exercise VERB bam-1807 155 11 skeletal skeletal ADJ bam-1807 155 12 muscle muscle NOUN bam-1807 155 13 european european PROPN bam-1807 155 14 journal journal PROPN bam-1807 155 15 translational translational ADJ bam-1807 155 16 myology myology NOUN bam-1807 155 17 myology myology NOUN bam-1807 155 18 reviews review VERB bam-1807 155 19 20 20 NUM bam-1807 155 20 ( ( PUNCT bam-1807 155 21 3 3 NUM bam-1807 155 22 ): ): PUNCT bam-1807 155 23 105 105 NUM bam-1807 155 24 - - SYM bam-1807 155 25 120 120 NUM bam-1807 155 26 , , PUNCT bam-1807 155 27 2010 2010 NUM bam-1807 155 28 110 110 NUM bam-1807 155 29 endurance endurance NOUN bam-1807 155 30 training training NOUN bam-1807 155 31 in in ADP bam-1807 155 32 mice mouse NOUN bam-1807 155 33 [ [ X bam-1807 155 34 66 66 NUM bam-1807 155 35 ] ] PUNCT bam-1807 155 36 and and CCONJ bam-1807 155 37 acute acute ADJ bam-1807 155 38 exercise exercise NOUN bam-1807 155 39 in in ADP bam-1807 155 40 humans human NOUN bam-1807 155 41 [ [ X bam-1807 155 42 69 69 NUM bam-1807 155 43 ] ] PUNCT bam-1807 155 44 increase increase VERB bam-1807 155 45 the the DET bam-1807 155 46 expression expression NOUN bam-1807 155 47 of of ADP bam-1807 155 48 pparβ pparβ NOUN bam-1807 155 49 / / SYM bam-1807 155 50 δ δ PROPN bam-1807 155 51 , , PUNCT bam-1807 155 52 which which PRON bam-1807 155 53 is be AUX bam-1807 155 54 several several ADJ bam-1807 155 55 - - PUNCT bam-1807 155 56 fold fold VERB bam-1807 155 57 more more ADV bam-1807 155 58 abundant abundant ADJ bam-1807 155 59 than than ADP bam-1807 155 60 either either CCONJ bam-1807 155 61 pparα pparα NOUN bam-1807 155 62 or or CCONJ bam-1807 155 63 pparγ pparγ ADJ bam-1807 155 64 in in ADP bam-1807 155 65 skeletal skeletal ADJ bam-1807 155 66 muscle muscle NOUN bam-1807 155 67 and and CCONJ bam-1807 155 68 is be AUX bam-1807 155 69 expressed express VERB bam-1807 155 70 at at ADP bam-1807 155 71 higher high ADJ bam-1807 155 72 levels level NOUN bam-1807 155 73 in in ADP bam-1807 155 74 slow slow ADJ bam-1807 155 75 / / SYM bam-1807 155 76 oxidative oxidative ADJ bam-1807 155 77 compared compare VERB bam-1807 155 78 with with ADP bam-1807 155 79 fast fast ADJ bam-1807 155 80 / / SYM bam-1807 155 81 glycolytic glycolytic ADJ bam-1807 155 82 muscles muscle NOUN bam-1807 155 83 . . PUNCT bam-1807 156 1 the the DET bam-1807 156 2 three three NUM bam-1807 156 3 ppar ppar NOUN bam-1807 156 4 isoforms isoform NOUN bam-1807 156 5 are be AUX bam-1807 156 6 members member NOUN bam-1807 156 7 of of ADP bam-1807 156 8 a a DET bam-1807 156 9 nuclear nuclear ADJ bam-1807 156 10 receptor receptor NOUN bam-1807 156 11 superfamily superfamily NOUN bam-1807 156 12 that that PRON bam-1807 156 13 binds bind VERB bam-1807 156 14 dna dna PROPN bam-1807 156 15 as as ADP bam-1807 156 16 heterodimers heterodimer NOUN bam-1807 156 17 with with ADP bam-1807 156 18 retinoid retinoid NOUN bam-1807 156 19 x x X bam-1807 156 20 receptors receptor NOUN bam-1807 156 21 ( ( PUNCT bam-1807 156 22 rxrs rxrs NOUN bam-1807 156 23 ) ) PUNCT bam-1807 156 24 . . PUNCT bam-1807 157 1 in in ADP bam-1807 157 2 mammals mammal NOUN bam-1807 157 3 they they PRON bam-1807 157 4 function function VERB bam-1807 157 5 as as ADP bam-1807 157 6 metabolic metabolic NOUN bam-1807 157 7 sensors sensor NOUN bam-1807 157 8 , , PUNCT bam-1807 157 9 being be AUX bam-1807 157 10 activated activate VERB bam-1807 157 11 by by ADP bam-1807 157 12 lipids lipid NOUN bam-1807 157 13 and and CCONJ bam-1807 157 14 affecting affect VERB bam-1807 157 15 lipid lipid NOUN bam-1807 157 16 metabolism metabolism NOUN bam-1807 157 17 . . PUNCT bam-1807 158 1 in in ADP bam-1807 158 2 fact fact NOUN bam-1807 158 3 , , PUNCT bam-1807 158 4 they they PRON bam-1807 158 5 control control VERB bam-1807 158 6 a a DET bam-1807 158 7 large large ADJ bam-1807 158 8 number number NOUN bam-1807 158 9 of of ADP bam-1807 158 10 genes gene NOUN bam-1807 158 11 encoding encode VERB bam-1807 158 12 proteins protein NOUN bam-1807 158 13 involved involve VERB bam-1807 158 14 in in ADP bam-1807 158 15 mitochondrial mitochondrial ADJ bam-1807 158 16 metabolism metabolism NOUN bam-1807 158 17 , , PUNCT bam-1807 158 18 including include VERB bam-1807 158 19 those those PRON bam-1807 158 20 encoding encode VERB bam-1807 158 21 proteins protein NOUN bam-1807 158 22 responsible responsible ADJ bam-1807 158 23 for for ADP bam-1807 158 24 fatty fatty NOUN bam-1807 158 25 acid acid NOUN bam-1807 158 26 transport transport NOUN bam-1807 158 27 and and CCONJ bam-1807 158 28 activation activation NOUN bam-1807 158 29 , , PUNCT bam-1807 158 30 mitochondrial mitochondrial ADJ bam-1807 158 31 β β NOUN bam-1807 158 32 - - NOUN bam-1807 158 33 oxidation oxidation NOUN bam-1807 158 34 , , PUNCT bam-1807 158 35 and and CCONJ bam-1807 158 36 energy energy NOUN bam-1807 158 37 uncoupling uncoupling NOUN bam-1807 158 38 ( ( PUNCT bam-1807 158 39 reviewed review VERB bam-1807 158 40 in in ADP bam-1807 158 41 [ [ X bam-1807 158 42 29 29 NUM bam-1807 158 43 ] ] NUM bam-1807 158 44 ) ) PUNCT bam-1807 158 45 . . PUNCT bam-1807 159 1 mitochondria mitochondria PROPN bam-1807 159 2 appear appear VERB bam-1807 159 3 to to PART bam-1807 159 4 be be AUX bam-1807 159 5 the the DET bam-1807 159 6 key key ADJ bam-1807 159 7 organelle organelle NOUN bam-1807 159 8 involved involve VERB bam-1807 159 9 in in ADP bam-1807 159 10 the the DET bam-1807 159 11 metabolic metabolic NOUN bam-1807 159 12 adaptation adaptation NOUN bam-1807 159 13 to to ADP bam-1807 159 14 endurance endurance NOUN bam-1807 159 15 training training NOUN bam-1807 159 16 . . PUNCT bam-1807 160 1 in in ADP bam-1807 160 2 fact fact NOUN bam-1807 160 3 , , PUNCT bam-1807 160 4 they they PRON bam-1807 160 5 host host VERB bam-1807 160 6 numerous numerous ADJ bam-1807 160 7 proteins protein NOUN bam-1807 160 8 involved involve VERB bam-1807 160 9 in in ADP bam-1807 160 10 beta beta ADJ bam-1807 160 11 oxidation oxidation NOUN bam-1807 160 12 , , PUNCT bam-1807 160 13 as as ADV bam-1807 160 14 well well ADV bam-1807 160 15 as as ADP bam-1807 160 16 all all DET bam-1807 160 17 proteins protein NOUN bam-1807 160 18 involved involve VERB bam-1807 160 19 in in ADP bam-1807 160 20 oxidative oxidative ADJ bam-1807 160 21 phosphorylation phosphorylation NOUN bam-1807 160 22 . . PUNCT bam-1807 161 1 mitochondrial mitochondrial ADJ bam-1807 161 2 dna dna PROPN bam-1807 161 3 content content NOUN bam-1807 161 4 increases increase NOUN bam-1807 161 5 in in ADP bam-1807 161 6 muscles muscle NOUN bam-1807 161 7 of of ADP bam-1807 161 8 endurance endurance NOUN bam-1807 161 9 athletes athlete NOUN bam-1807 161 10 , , PUNCT bam-1807 161 11 together together ADV bam-1807 161 12 with with ADP bam-1807 161 13 the the DET bam-1807 161 14 level level NOUN bam-1807 161 15 of of ADP bam-1807 161 16 nuclear nuclear ADJ bam-1807 161 17 transcription transcription NOUN bam-1807 161 18 factors factor NOUN bam-1807 161 19 ( ( PUNCT bam-1807 161 20 nrf-1 nrf-1 NUM bam-1807 161 21 , , PUNCT bam-1807 161 22 nrf-2 nrf-2 NUM bam-1807 161 23 and and CCONJ bam-1807 161 24 tfam tfam NOUN bam-1807 161 25 ) ) PUNCT bam-1807 161 26 that that PRON bam-1807 161 27 control control VERB bam-1807 161 28 nuclear nuclear NOUN bam-1807 161 29 - - PUNCT bam-1807 161 30 encoded encode VERB bam-1807 161 31 mitochondrial mitochondrial ADJ bam-1807 161 32 genes gene NOUN bam-1807 161 33 . . PUNCT bam-1807 162 1 as as ADP bam-1807 162 2 a a DET bam-1807 162 3 result result NOUN bam-1807 162 4 , , PUNCT bam-1807 162 5 mitochondrially mitochondrially ADV bam-1807 162 6 encoded encode VERB bam-1807 162 7 rnas rna NOUN bam-1807 162 8 as as ADV bam-1807 162 9 well well ADV bam-1807 162 10 as as ADP bam-1807 162 11 nuclear nuclear NOUN bam-1807 162 12 - - PUNCT bam-1807 162 13 encoded encode VERB bam-1807 162 14 rnas rna NOUN bam-1807 162 15 are be AUX bam-1807 162 16 all all PRON bam-1807 162 17 increased increase VERB bam-1807 162 18 coordinately coordinately ADV bam-1807 162 19 in in ADP bam-1807 162 20 the the DET bam-1807 162 21 endurance endurance NOUN bam-1807 162 22 athletes athlete NOUN bam-1807 162 23 [ [ X bam-1807 162 24 86 86 NUM bam-1807 162 25 ] ] PUNCT bam-1807 162 26 . . PUNCT bam-1807 163 1 in in ADP bam-1807 163 2 turn turn NOUN bam-1807 163 3 , , PUNCT bam-1807 163 4 nuclear nuclear ADJ bam-1807 163 5 transcription transcription NOUN bam-1807 163 6 factors factor NOUN bam-1807 163 7 that that PRON bam-1807 163 8 promote promote VERB bam-1807 163 9 mitochondrial mitochondrial ADJ bam-1807 163 10 biogenesis biogenesis NOUN bam-1807 163 11 are be AUX bam-1807 163 12 activated activate VERB bam-1807 163 13 by by ADP bam-1807 163 14 the the DET bam-1807 163 15 transcriptional transcriptional ADJ bam-1807 163 16 co co ADJ bam-1807 163 17 - - NOUN bam-1807 163 18 activator activator NOUN bam-1807 163 19 pgc1 pgc1 NOUN bam-1807 163 20 - - PUNCT bam-1807 163 21 α α NOUN bam-1807 163 22 . . PUNCT bam-1807 164 1 pgc1 pgc1 NOUN bam-1807 164 2 - - PUNCT bam-1807 164 3 α α PROPN bam-1807 164 4 is be AUX bam-1807 164 5 expressed express VERB bam-1807 164 6 at at ADP bam-1807 164 7 lower low ADJ bam-1807 164 8 levels level NOUN bam-1807 164 9 in in ADP bam-1807 164 10 fast fast ADV bam-1807 164 11 than than ADP bam-1807 164 12 in in ADP bam-1807 164 13 slow slow ADJ bam-1807 164 14 fibers fiber NOUN bam-1807 164 15 , , PUNCT bam-1807 164 16 but but CCONJ bam-1807 164 17 endurance endurance NOUN bam-1807 164 18 exercise exercise NOUN bam-1807 164 19 readily readily ADV bam-1807 164 20 increases increase VERB bam-1807 164 21 its its PRON bam-1807 164 22 expression expression NOUN bam-1807 164 23 , , PUNCT bam-1807 164 24 allowing allow VERB bam-1807 164 25 it it PRON bam-1807 164 26 to to PART bam-1807 164 27 stimulate stimulate VERB bam-1807 164 28 mitochondrial mitochondrial ADJ bam-1807 164 29 biogenesis biogenesis NOUN bam-1807 164 30 and and CCONJ bam-1807 164 31 synthesis synthesis NOUN bam-1807 164 32 of of ADP bam-1807 164 33 oxidative oxidative ADJ bam-1807 164 34 enzymes enzyme NOUN bam-1807 164 35 , , PUNCT bam-1807 164 36 thus thus ADV bam-1807 164 37 making make VERB bam-1807 164 38 fasttwitch fasttwitch ADJ bam-1807 164 39 muscles muscle NOUN bam-1807 164 40 more more ADV bam-1807 164 41 resistant resistant ADJ bam-1807 164 42 to to ADP bam-1807 164 43 fatigue fatigue NOUN bam-1807 164 44 [ [ X bam-1807 164 45 64 64 NUM bam-1807 164 46 ] ] PUNCT bam-1807 164 47 . . PUNCT bam-1807 165 1 the the DET bam-1807 165 2 expression expression NOUN bam-1807 165 3 of of ADP bam-1807 165 4 pgc1 pgc1 PROPN bam-1807 165 5 - - PUNCT bam-1807 165 6 α α PROPN bam-1807 165 7 is be AUX bam-1807 165 8 positively positively ADV bam-1807 165 9 controlled control VERB bam-1807 165 10 by by ADP bam-1807 165 11 diverse diverse ADJ bam-1807 165 12 pathways pathway NOUN bam-1807 165 13 ( ( PUNCT bam-1807 165 14 reviewed review VERB bam-1807 165 15 by by ADP bam-1807 165 16 [ [ X bam-1807 165 17 39 39 NUM bam-1807 165 18 , , PUNCT bam-1807 165 19 40 40 NUM bam-1807 165 20 , , PUNCT bam-1807 165 21 100 100 NUM bam-1807 165 22 , , PUNCT bam-1807 165 23 123 123 NUM bam-1807 165 24 ] ] PUNCT bam-1807 165 25 ) ) PUNCT bam-1807 165 26 , , PUNCT bam-1807 165 27 such such ADJ bam-1807 165 28 as as ADP bam-1807 165 29 reactive reactive ADJ bam-1807 165 30 oxygen oxygen NOUN bam-1807 165 31 species specie NOUN bam-1807 165 32 ( ( PUNCT bam-1807 165 33 ros ros PROPN bam-1807 165 34 ) ) PUNCT bam-1807 165 35 , , PUNCT bam-1807 165 36 calcineurin calcineurin NOUN bam-1807 165 37 and and CCONJ bam-1807 165 38 ca2+/calmodulin ca2+/calmodulin NOUN bam-1807 165 39 - - PUNCT bam-1807 165 40 dependent dependent ADJ bam-1807 165 41 protein protein NOUN bam-1807 165 42 kinases kinase NOUN bam-1807 165 43 ( ( PUNCT bam-1807 165 44 camks camks NOUN bam-1807 165 45 ) ) PUNCT bam-1807 165 46 , , PUNCT bam-1807 165 47 that that PRON bam-1807 165 48 sense sense NOUN bam-1807 165 49 intracellular intracellular ADJ bam-1807 165 50 ca2 ca2 PROPN bam-1807 165 51 + + NOUN bam-1807 165 52 concentration concentration NOUN bam-1807 165 53 , , PUNCT bam-1807 165 54 transcription transcription NOUN bam-1807 165 55 factors factor NOUN bam-1807 165 56 mef2 mef2 PROPN bam-1807 165 57 ( ( PUNCT bam-1807 165 58 myocyte myocyte NOUN bam-1807 165 59 enhancer enhancer NOUN bam-1807 165 60 factor2 factor2 PROPN bam-1807 165 61 ) ) PUNCT bam-1807 165 62 , , PUNCT bam-1807 165 63 which which PRON bam-1807 165 64 in in ADP bam-1807 165 65 many many ADJ bam-1807 165 66 tissues tissue NOUN bam-1807 165 67 control control VERB bam-1807 165 68 the the DET bam-1807 165 69 stress stress NOUN bam-1807 165 70 response response NOUN bam-1807 165 71 , , PUNCT bam-1807 165 72 p38 p38 NOUN bam-1807 165 73 mitogen mitogen NOUN bam-1807 165 74 - - PUNCT bam-1807 165 75 activated activate VERB bam-1807 165 76 protein protein NOUN bam-1807 165 77 kinase kinase NOUN bam-1807 165 78 ( ( PUNCT bam-1807 165 79 p38mapk p38mapk PROPN bam-1807 165 80 ) ) PUNCT bam-1807 165 81 – – PUNCT bam-1807 165 82 which which PRON bam-1807 165 83 in in ADP bam-1807 165 84 turn turn NOUN bam-1807 165 85 requires require VERB bam-1807 165 86 the the DET bam-1807 165 87 activity activity NOUN bam-1807 165 88 of of ADP bam-1807 165 89 the the DET bam-1807 165 90 transcription transcription NOUN bam-1807 165 91 factor factor NOUN bam-1807 165 92 atf2 atf2 NOUN bam-1807 165 93 , , PUNCT bam-1807 165 94 and and CCONJ bam-1807 165 95 amp amp PROPN bam-1807 165 96 kinase kinase PROPN bam-1807 165 97 . . PUNCT bam-1807 166 1 this this DET bam-1807 166 2 last last ADJ bam-1807 166 3 activity activity NOUN bam-1807 166 4 is be AUX bam-1807 166 5 triggered trigger VERB bam-1807 166 6 by by ADP bam-1807 166 7 signals signal NOUN bam-1807 166 8 of of ADP bam-1807 166 9 energy energy NOUN bam-1807 166 10 shortage shortage NOUN bam-1807 166 11 [ [ X bam-1807 166 12 29 29 NUM bam-1807 166 13 ] ] PUNCT bam-1807 166 14 . . PUNCT bam-1807 167 1 in in ADP bam-1807 167 2 fact fact NOUN bam-1807 167 3 , , PUNCT bam-1807 167 4 as as SCONJ bam-1807 167 5 already already ADV bam-1807 167 6 pointed point VERB bam-1807 167 7 out out ADP bam-1807 167 8 , , PUNCT bam-1807 167 9 amp amp PROPN bam-1807 167 10 kinase kinase PROPN bam-1807 167 11 controls control VERB bam-1807 167 12 the the DET bam-1807 167 13 pathways pathway NOUN bam-1807 167 14 that that PRON bam-1807 167 15 lead lead VERB bam-1807 167 16 to to ADP bam-1807 167 17 a a DET bam-1807 167 18 better well ADJ bam-1807 167 19 utilization utilization NOUN bam-1807 167 20 of of ADP bam-1807 167 21 the the DET bam-1807 167 22 available available ADJ bam-1807 167 23 energy energy NOUN bam-1807 167 24 , , PUNCT bam-1807 167 25 including include VERB bam-1807 167 26 the the DET bam-1807 167 27 shift shift NOUN bam-1807 167 28 from from ADP bam-1807 167 29 the the DET bam-1807 167 30 glycolytic glycolytic NOUN bam-1807 167 31 to to ADP bam-1807 167 32 the the DET bam-1807 167 33 oxidative oxidative ADJ bam-1807 167 34 pathways pathway NOUN bam-1807 167 35 . . PUNCT bam-1807 168 1 more more ADV bam-1807 168 2 recently recently ADV bam-1807 168 3 , , PUNCT bam-1807 168 4 it it PRON bam-1807 168 5 was be AUX bam-1807 168 6 suggested suggest VERB bam-1807 168 7 that that SCONJ bam-1807 168 8 the the DET bam-1807 168 9 ratio ratio NOUN bam-1807 168 10 nad+/nadh nad+/nadh NOUN bam-1807 168 11 might might AUX bam-1807 168 12 be be AUX bam-1807 168 13 involved involve VERB bam-1807 168 14 in in ADP bam-1807 168 15 the the DET bam-1807 168 16 regulation regulation NOUN bam-1807 168 17 of of ADP bam-1807 168 18 skeletal skeletal ADJ bam-1807 168 19 muscle muscle NOUN bam-1807 168 20 gene gene NOUN bam-1807 168 21 expression expression NOUN bam-1807 168 22 , , PUNCT bam-1807 168 23 after after ADP bam-1807 168 24 the the DET bam-1807 168 25 observation observation NOUN bam-1807 168 26 that that PRON bam-1807 168 27 silent silent ADJ bam-1807 168 28 information information NOUN bam-1807 168 29 regulator regulator NOUN bam-1807 168 30 t1 t1 NOUN bam-1807 168 31 ( ( PUNCT bam-1807 168 32 sirt1 sirt1 NOUN bam-1807 168 33 ) ) PUNCT bam-1807 168 34 , , PUNCT bam-1807 168 35 an an DET bam-1807 168 36 nad+-dependent nad+-dependent NOUN bam-1807 168 37 deacetylase deacetylase NOUN bam-1807 168 38 , , PUNCT bam-1807 168 39 deacetylates deacetylate VERB bam-1807 168 40 and and CCONJ bam-1807 168 41 activates activate VERB bam-1807 168 42 pgc1 pgc1 PROPN bam-1807 168 43 - - PUNCT bam-1807 168 44 α α PROPN bam-1807 168 45 . . PUNCT bam-1807 169 1 since since SCONJ bam-1807 169 2 deacetylation deacetylation NOUN bam-1807 169 3 by by ADP bam-1807 169 4 sirt1 sirt1 NOUN bam-1807 169 5 favors favor NOUN bam-1807 169 6 pgc1 pgc1 PROPN bam-1807 169 7 - - PUNCT bam-1807 169 8 α α NUM bam-1807 169 9 translocation translocation NOUN bam-1807 169 10 to to ADP bam-1807 169 11 the the DET bam-1807 169 12 nucleus nucleus NOUN bam-1807 169 13 , , PUNCT bam-1807 169 14 thus thus ADV bam-1807 169 15 promoting promote VERB bam-1807 169 16 its its PRON bam-1807 169 17 activity activity NOUN bam-1807 169 18 even even ADV bam-1807 169 19 in in ADP bam-1807 169 20 the the DET bam-1807 169 21 absence absence NOUN bam-1807 169 22 of of ADP bam-1807 169 23 transcriptional transcriptional ADJ bam-1807 169 24 upregulation upregulation NOUN bam-1807 169 25 , , PUNCT bam-1807 169 26 sirt1 sirt1 NOUN bam-1807 169 27 may may AUX bam-1807 169 28 be be AUX bam-1807 169 29 regarded regard VERB bam-1807 169 30 as as ADP bam-1807 169 31 a a DET bam-1807 169 32 positive positive ADJ bam-1807 169 33 regulator regulator NOUN bam-1807 169 34 of of ADP bam-1807 169 35 mitochondrial mitochondrial ADJ bam-1807 169 36 biogenesis biogenesis NOUN bam-1807 169 37 . . PUNCT bam-1807 170 1 cantò cantò PROPN bam-1807 170 2 et et PROPN bam-1807 170 3 al al PROPN bam-1807 170 4 . . PUNCT bam-1807 171 1 [ [ X bam-1807 171 2 15 15 NUM bam-1807 171 3 ] ] PUNCT bam-1807 171 4 have have AUX bam-1807 171 5 shown show VERB bam-1807 171 6 that that DET bam-1807 171 7 acute acute ADJ bam-1807 171 8 exercise exercise NOUN bam-1807 171 9 , , PUNCT bam-1807 171 10 by by ADP bam-1807 171 11 activating activate VERB bam-1807 171 12 ampk ampk NOUN bam-1807 171 13 , , PUNCT bam-1807 171 14 modulates modulate NOUN bam-1807 171 15 nad+ nad+ PROPN bam-1807 171 16 metabolism metabolism NOUN bam-1807 171 17 and and CCONJ bam-1807 171 18 sirt1 sirt1 NOUN bam-1807 171 19 mediated mediate VERB bam-1807 171 20 - - PUNCT bam-1807 171 21 deacetylation deacetylation NOUN bam-1807 171 22 of of ADP bam-1807 171 23 pgc1 pgc1 PROPN bam-1807 171 24 - - PUNCT bam-1807 171 25 α α PRON bam-1807 171 26 . . PUNCT bam-1807 172 1 notably notably ADV bam-1807 172 2 , , PUNCT bam-1807 172 3 sirt1 sirt1 NOUN bam-1807 172 4 and and CCONJ bam-1807 172 5 pgc1 pgc1 PROPN bam-1807 172 6 - - PUNCT bam-1807 172 7 α α PROPN bam-1807 172 8 mrna mrna PROPN bam-1807 172 9 expression expression NOUN bam-1807 172 10 have have AUX bam-1807 172 11 been be AUX bam-1807 172 12 shown show VERB bam-1807 172 13 to to PART bam-1807 172 14 increase increase VERB bam-1807 172 15 in in ADP bam-1807 172 16 parallel parallel ADJ bam-1807 172 17 following follow VERB bam-1807 172 18 caloric caloric NOUN bam-1807 172 19 restriction restriction NOUN bam-1807 172 20 and and CCONJ bam-1807 172 21 caloric caloric NOUN bam-1807 172 22 restriction restriction NOUN bam-1807 172 23 combined combine VERB bam-1807 172 24 with with ADP bam-1807 172 25 exercise exercise NOUN bam-1807 172 26 . . PUNCT bam-1807 173 1 in in ADP bam-1807 173 2 different different ADJ bam-1807 173 3 cellular cellular ADJ bam-1807 173 4 contexts contexts NOUN bam-1807 173 5 , , PUNCT bam-1807 173 6 the the DET bam-1807 173 7 nad+/nadh nad+/nadh NOUN bam-1807 173 8 ratio ratio NOUN bam-1807 173 9 controls control NOUN bam-1807 173 10 also also ADV bam-1807 173 11 the the DET bam-1807 173 12 activity activity NOUN bam-1807 173 13 of of ADP bam-1807 173 14 amp amp PROPN bam-1807 173 15 kinase kinase PROPN bam-1807 173 16 and and CCONJ bam-1807 173 17 of of ADP bam-1807 173 18 acetyl acetyl NOUN bam-1807 173 19 - - PUNCT bam-1807 173 20 coa coa NOUN bam-1807 173 21 synthase synthase NOUN bam-1807 173 22 i i PRON bam-1807 173 23 ; ; PUNCT bam-1807 173 24 these these DET bam-1807 173 25 studies study NOUN bam-1807 173 26 collectively collectively ADV bam-1807 173 27 suggest suggest VERB bam-1807 173 28 that that SCONJ bam-1807 173 29 sirt1 sirt1 NOUN bam-1807 173 30 may may AUX bam-1807 173 31 establish establish VERB bam-1807 173 32 regulatory regulatory ADJ bam-1807 173 33 cross cross NOUN bam-1807 173 34 - - NOUN bam-1807 173 35 talk talk NOUN bam-1807 173 36 among among ADP bam-1807 173 37 various various ADJ bam-1807 173 38 energysensing energysense VERB bam-1807 173 39 molecules molecule NOUN bam-1807 173 40 . . PUNCT bam-1807 174 1 last last ADJ bam-1807 174 2 but but CCONJ bam-1807 174 3 not not PART bam-1807 174 4 least least ADJ bam-1807 174 5 among among ADP bam-1807 174 6 the the DET bam-1807 174 7 physiological physiological ADJ bam-1807 174 8 triggers trigger NOUN bam-1807 174 9 controlling control VERB bam-1807 174 10 the the DET bam-1807 174 11 metabolic metabolic NOUN bam-1807 174 12 adaptation adaptation NOUN bam-1807 174 13 of of ADP bam-1807 174 14 skeletal skeletal ADJ bam-1807 174 15 muscle muscle NOUN bam-1807 174 16 to to ADP bam-1807 174 17 endurance endurance NOUN bam-1807 174 18 exercise exercise NOUN bam-1807 174 19 , , PUNCT bam-1807 174 20 the the DET bam-1807 174 21 central central ADJ bam-1807 174 22 role role NOUN bam-1807 174 23 exerted exert VERB bam-1807 174 24 by by ADP bam-1807 174 25 local local ADJ bam-1807 174 26 hypoxia hypoxia NOUN bam-1807 174 27 that that PRON bam-1807 174 28 generates generate VERB bam-1807 174 29 during during ADP bam-1807 174 30 strenuous strenuous ADJ bam-1807 174 31 exercise exercise NOUN bam-1807 174 32 has have AUX bam-1807 174 33 been be AUX bam-1807 174 34 stressed stress VERB bam-1807 174 35 in in ADP bam-1807 174 36 recent recent ADJ bam-1807 174 37 works work NOUN bam-1807 174 38 [ [ X bam-1807 174 39 2 2 NUM bam-1807 174 40 , , PUNCT bam-1807 174 41 19 19 NUM bam-1807 174 42 ] ] PUNCT bam-1807 174 43 . . PUNCT bam-1807 175 1 by by ADP bam-1807 175 2 stabilizing stabilize VERB bam-1807 175 3 the the DET bam-1807 175 4 alpha alpha ADJ bam-1807 175 5 subunit subunit NOUN bam-1807 175 6 of of ADP bam-1807 175 7 hypoxia hypoxia NOUN bam-1807 175 8 - - PUNCT bam-1807 175 9 inducible inducible ADJ bam-1807 175 10 factor factor NOUN bam-1807 175 11 1 1 NUM bam-1807 175 12 ( ( PUNCT bam-1807 175 13 hif-1 hif-1 NUM bam-1807 175 14 ) ) PUNCT bam-1807 175 15 , , PUNCT bam-1807 175 16 hypoxia hypoxia NOUN bam-1807 175 17 triggers trigger VERB bam-1807 175 18 the the DET bam-1807 175 19 orchestration orchestration NOUN bam-1807 175 20 of of ADP bam-1807 175 21 both both DET bam-1807 175 22 mitochondrial mitochondrial ADJ bam-1807 175 23 biogenesis biogenesis NOUN bam-1807 175 24 and and CCONJ bam-1807 176 1 neo neo NOUN bam-1807 176 2 - - NOUN bam-1807 176 3 angiogenesis angiogenesis NOUN bam-1807 176 4 occurring occurring NOUN bam-1807 176 5 in in ADP bam-1807 176 6 the the DET bam-1807 176 7 exercised exercised ADJ bam-1807 176 8 muscle muscle NOUN bam-1807 176 9 . . PUNCT bam-1807 177 1 it it PRON bam-1807 177 2 should should AUX bam-1807 177 3 be be AUX bam-1807 177 4 noted note VERB bam-1807 177 5 that that SCONJ bam-1807 177 6 hif-1 hif-1 PUNCT bam-1807 177 7 is be AUX bam-1807 177 8 directly directly ADV bam-1807 177 9 upstream upstream ADJ bam-1807 177 10 of of ADP bam-1807 177 11 both both PRON bam-1807 177 12 pgc1 pgc1 PROPN bam-1807 177 13 - - PUNCT bam-1807 177 14 α α PROPN bam-1807 177 15 and and CCONJ bam-1807 177 16 vegf vegf NOUN bam-1807 177 17 induction induction NOUN bam-1807 177 18 . . PUNCT bam-1807 178 1 together together ADV bam-1807 178 2 with with ADP bam-1807 178 3 insulin insulin NOUN bam-1807 178 4 , , PUNCT bam-1807 178 5 exercise exercise NOUN bam-1807 178 6 powerfully powerfully ADV bam-1807 178 7 stimulates stimulate VERB bam-1807 178 8 skeletal skeletal ADJ bam-1807 178 9 muscle muscle NOUN bam-1807 178 10 glucose glucose NOUN bam-1807 178 11 transport transport NOUN bam-1807 178 12 . . PUNCT bam-1807 179 1 both both DET bam-1807 179 2 insulin insulin NOUN bam-1807 179 3 and and CCONJ bam-1807 179 4 exercise exercise NOUN bam-1807 179 5 stimulate stimulate VERB bam-1807 179 6 the the DET bam-1807 179 7 translocation translocation NOUN bam-1807 179 8 of of ADP bam-1807 179 9 glucose glucose NOUN bam-1807 179 10 transporter transporter NOUN bam-1807 179 11 glut4 glut4 NOUN bam-1807 179 12 from from ADP bam-1807 179 13 an an DET bam-1807 179 14 intracellular intracellular ADJ bam-1807 179 15 location location NOUN bam-1807 179 16 to to ADP bam-1807 179 17 the the DET bam-1807 179 18 plasma plasma NOUN bam-1807 179 19 membrane membrane NOUN bam-1807 179 20 and and CCONJ bam-1807 179 21 t t NOUN bam-1807 179 22 - - PUNCT bam-1807 179 23 tubules tubule NOUN bam-1807 179 24 as as ADV bam-1807 179 25 well well ADV bam-1807 179 26 as as ADP bam-1807 179 27 its its PRON bam-1807 179 28 neosynthesis neosynthesis NOUN bam-1807 179 29 . . PUNCT bam-1807 180 1 many many ADJ bam-1807 180 2 lines line NOUN bam-1807 180 3 of of ADP bam-1807 180 4 evidence evidence NOUN bam-1807 180 5 suggest suggest VERB bam-1807 180 6 that that SCONJ bam-1807 180 7 insulin insulin NOUN bam-1807 180 8 and and CCONJ bam-1807 180 9 exercise exercise NOUN bam-1807 180 10 achieve achieve VERB bam-1807 180 11 these these DET bam-1807 180 12 results result NOUN bam-1807 180 13 by by ADP bam-1807 180 14 different different ADJ bam-1807 180 15 pathways pathway NOUN bam-1807 180 16 ( ( PUNCT bam-1807 180 17 reviewed review VERB bam-1807 180 18 in in ADP bam-1807 180 19 [ [ X bam-1807 180 20 91 91 NUM bam-1807 180 21 ] ] PUNCT bam-1807 180 22 ) ) PUNCT bam-1807 180 23 . . PUNCT bam-1807 181 1 briefly briefly NOUN bam-1807 181 2 , , PUNCT bam-1807 181 3 the the DET bam-1807 181 4 most most ADV bam-1807 181 5 important important ADJ bam-1807 181 6 mediators mediator NOUN bam-1807 181 7 of of ADP bam-1807 181 8 these these DET bam-1807 181 9 pathways pathway NOUN bam-1807 181 10 are be AUX bam-1807 181 11 amp amp PROPN bam-1807 181 12 kinase kinase PROPN bam-1807 181 13 , , PUNCT bam-1807 181 14 ca2+/calmodulin ca2+/calmodulin NOUN bam-1807 181 15 - - PUNCT bam-1807 181 16 dependent dependent ADJ bam-1807 181 17 protein protein NOUN bam-1807 181 18 kinases kinase NOUN bam-1807 181 19 , , PUNCT bam-1807 181 20 protein protein NOUN bam-1807 181 21 kinase kinase NOUN bam-1807 181 22 c c X bam-1807 181 23 , , PUNCT bam-1807 181 24 and and CCONJ bam-1807 181 25 the the DET bam-1807 181 26 akt akt NOUN bam-1807 181 27 substrate substrate NOUN bam-1807 181 28 of of ADP bam-1807 181 29 160 160 NUM bam-1807 181 30 kda kda NOUN bam-1807 181 31 ( ( PUNCT bam-1807 181 32 as160 as160 PROPN bam-1807 181 33 ) ) PUNCT bam-1807 181 34 . . PUNCT bam-1807 182 1 this this DET bam-1807 182 2 last last ADJ bam-1807 182 3 protein protein NOUN bam-1807 182 4 may may AUX bam-1807 182 5 serve serve VERB bam-1807 182 6 as as ADP bam-1807 182 7 a a DET bam-1807 182 8 point point NOUN bam-1807 182 9 of of ADP bam-1807 182 10 convergence convergence NOUN bam-1807 182 11 of of ADP bam-1807 182 12 both both DET bam-1807 182 13 insulinand insulinand NOUN bam-1807 182 14 contractiondependent contractiondependent NOUN bam-1807 182 15 signaling signal VERB bam-1807 182 16 in in ADP bam-1807 182 17 the the DET bam-1807 182 18 regulation regulation NOUN bam-1807 182 19 of of ADP bam-1807 182 20 glucose glucose NOUN bam-1807 182 21 uptake uptake ADJ bam-1807 182 22 [ [ X bam-1807 182 23 56 56 NUM bam-1807 182 24 ] ] PUNCT bam-1807 182 25 . . PUNCT bam-1807 183 1 it it PRON bam-1807 183 2 is be AUX bam-1807 183 3 important important ADJ bam-1807 183 4 to to PART bam-1807 183 5 realize realize VERB bam-1807 183 6 that that DET bam-1807 183 7 fiber fiber NOUN bam-1807 183 8 type type NOUN bam-1807 183 9 transition transition NOUN bam-1807 183 10 , , PUNCT bam-1807 183 11 mitochondrial mitochondrial ADJ bam-1807 183 12 biogenesis biogenesis NOUN bam-1807 183 13 , , PUNCT bam-1807 183 14 increase increase NOUN bam-1807 183 15 in in ADP bam-1807 183 16 glut4 glut4 NOUN bam-1807 183 17 and and CCONJ bam-1807 183 18 neoangiogenesis neoangiogenesis NOUN bam-1807 183 19 can can AUX bam-1807 183 20 occur occur VERB bam-1807 183 21 independently independently ADV bam-1807 183 22 from from ADP bam-1807 183 23 each each DET bam-1807 183 24 other other ADJ bam-1807 183 25 , , PUNCT bam-1807 183 26 thus thus ADV bam-1807 183 27 suggesting suggest VERB bam-1807 183 28 distinct distinct ADJ bam-1807 183 29 signaling signal VERB bam-1807 183 30 mechanisms mechanism NOUN bam-1807 183 31 , , PUNCT bam-1807 183 32 although although SCONJ bam-1807 183 33 these these DET bam-1807 183 34 events event NOUN bam-1807 183 35 do do AUX bam-1807 183 36 share share VERB bam-1807 183 37 common common ADJ bam-1807 183 38 triggers trigger NOUN bam-1807 183 39 and and CCONJ bam-1807 183 40 display display VERB bam-1807 183 41 some some DET bam-1807 183 42 overlapping overlap VERB bam-1807 183 43 in in ADP bam-1807 183 44 their their PRON bam-1807 183 45 activation activation NOUN bam-1807 183 46 pathways pathway NOUN bam-1807 183 47 . . PUNCT bam-1807 184 1 the the DET bam-1807 184 2 transcriptional transcriptional ADJ bam-1807 184 3 modifications modification NOUN bam-1807 184 4 leading lead VERB bam-1807 184 5 to to ADP bam-1807 184 6 the the DET bam-1807 184 7 metabolic metabolic NOUN bam-1807 184 8 adaptation adaptation NOUN bam-1807 184 9 of of ADP bam-1807 184 10 the the DET bam-1807 184 11 exercised exercise VERB bam-1807 184 12 muscles muscle NOUN bam-1807 184 13 occur occur VERB bam-1807 184 14 during during ADP bam-1807 184 15 the the DET bam-1807 184 16 first first ADJ bam-1807 184 17 24 24 NUM bam-1807 184 18 hours hour NOUN bam-1807 184 19 of of ADP bam-1807 184 20 recovery recovery NOUN bam-1807 184 21 from from ADP bam-1807 184 22 a a DET bam-1807 184 23 training training NOUN bam-1807 184 24 session session NOUN bam-1807 184 25 . . PUNCT bam-1807 185 1 at at ADP bam-1807 185 2 steady steady ADJ bam-1807 185 3 state state NOUN bam-1807 185 4 , , PUNCT bam-1807 185 5 in in ADP bam-1807 185 6 the the DET bam-1807 185 7 muscles muscle NOUN bam-1807 185 8 of of ADP bam-1807 185 9 endurance endurance NOUN bam-1807 185 10 athletes athlete NOUN bam-1807 185 11 only only ADV bam-1807 185 12 one one NUM bam-1807 185 13 enzyme enzyme NOUN bam-1807 185 14 of of ADP bam-1807 185 15 the the DET bam-1807 185 16 oxidative oxidative ADJ bam-1807 185 17 pathway pathway NOUN bam-1807 185 18 is be AUX bam-1807 185 19 upregulated upregulate VERB bam-1807 185 20 at at ADP bam-1807 185 21 the the DET bam-1807 185 22 mrna mrna PROPN bam-1807 185 23 level level NOUN bam-1807 185 24 : : PUNCT bam-1807 185 25 gadph gadph NOUN bam-1807 186 1 [ [ X bam-1807 186 2 102 102 NUM bam-1807 186 3 ] ] PUNCT bam-1807 186 4 . . PUNCT bam-1807 187 1 this this PRON bam-1807 187 2 suggests suggest VERB bam-1807 187 3 that that SCONJ bam-1807 187 4 the the DET bam-1807 187 5 muscle muscle NOUN bam-1807 187 6 quickly quickly ADV bam-1807 187 7 adjusts adjust VERB bam-1807 187 8 itself itself PRON bam-1807 187 9 to to ADP bam-1807 187 10 variable variable ADJ bam-1807 187 11 levels level NOUN bam-1807 187 12 according accord VERB bam-1807 187 13 to to ADP bam-1807 187 14 the the DET bam-1807 187 15 functional functional ADJ bam-1807 187 16 demands demand NOUN bam-1807 187 17 . . PUNCT bam-1807 188 1 muscle muscle NOUN bam-1807 188 2 malleability malleability NOUN bam-1807 188 3 also also ADV bam-1807 188 4 acts act VERB bam-1807 188 5 in in ADP bam-1807 188 6 the the DET bam-1807 188 7 detraining detraining NOUN bam-1807 188 8 phase phase NOUN bam-1807 188 9 , , PUNCT bam-1807 188 10 when when SCONJ bam-1807 188 11 the the DET bam-1807 188 12 exercise exercise NOUN bam-1807 188 13 - - PUNCT bam-1807 188 14 induced induce VERB bam-1807 188 15 adaptative adaptative ADJ bam-1807 188 16 modifications modification NOUN bam-1807 188 17 are be AUX bam-1807 188 18 reversed reverse VERB bam-1807 188 19 as as SCONJ bam-1807 188 20 the the DET bam-1807 188 21 training training NOUN bam-1807 188 22 stimulus stimulus NOUN bam-1807 188 23 is be AUX bam-1807 188 24 no no ADV bam-1807 188 25 longer long ADV bam-1807 188 26 present present ADJ bam-1807 188 27 and and CCONJ bam-1807 188 28 fiber fiber NOUN bam-1807 188 29 type type NOUN bam-1807 188 30 spectrum spectrum NOUN bam-1807 188 31 , , PUNCT bam-1807 188 32 metabolism metabolism NOUN bam-1807 188 33 , , PUNCT bam-1807 188 34 mitochondrial mitochondrial ADJ bam-1807 188 35 the the DET bam-1807 188 36 exercised exercise VERB bam-1807 188 37 skeletal skeletal ADJ bam-1807 188 38 muscle muscle NOUN bam-1807 188 39 european european PROPN bam-1807 188 40 journal journal PROPN bam-1807 188 41 translational translational ADJ bam-1807 188 42 myology myology NOUN bam-1807 188 43 myology myology NOUN bam-1807 188 44 reviews review VERB bam-1807 188 45 20 20 NUM bam-1807 188 46 ( ( PUNCT bam-1807 188 47 3 3 NUM bam-1807 188 48 ): ): PUNCT bam-1807 188 49 105 105 NUM bam-1807 188 50 - - SYM bam-1807 188 51 120 120 NUM bam-1807 188 52 , , PUNCT bam-1807 188 53 2010 2010 NUM bam-1807 188 54 111 111 NUM bam-1807 188 55 content content NOUN bam-1807 188 56 and and CCONJ bam-1807 188 57 vascularization vascularization NOUN bam-1807 189 1 all all PRON bam-1807 189 2 come come VERB bam-1807 189 3 to to PART bam-1807 189 4 resemble resemble VERB bam-1807 189 5 again again ADV bam-1807 189 6 to to ADP bam-1807 189 7 the the DET bam-1807 189 8 pattern pattern NOUN bam-1807 189 9 established establish VERB bam-1807 189 10 by by ADP bam-1807 189 11 basal basal ADJ bam-1807 189 12 nerve nerve NOUN bam-1807 189 13 and and CCONJ bam-1807 189 14 hormone hormone NOUN bam-1807 189 15 activity activity NOUN bam-1807 189 16 during during ADP bam-1807 189 17 adulthood adulthood NOUN bam-1807 189 18 [ [ X bam-1807 189 19 28 28 NUM bam-1807 189 20 ] ] PUNCT bam-1807 189 21 . . PUNCT bam-1807 190 1 5 5 X bam-1807 190 2 . . X bam-1807 190 3 exercise exercise NOUN bam-1807 190 4 - - PUNCT bam-1807 190 5 induced induce VERB bam-1807 190 6 neo neo NOUN bam-1807 190 7 - - ADJ bam-1807 190 8 angiogenesis angiogenesis NOUN bam-1807 190 9 exercise exercise NOUN bam-1807 190 10 training training NOUN bam-1807 190 11 - - PUNCT bam-1807 190 12 induced induce VERB bam-1807 190 13 increases increase NOUN bam-1807 190 14 in in ADP bam-1807 190 15 muscle muscle NOUN bam-1807 190 16 oxidative oxidative ADJ bam-1807 190 17 capacity capacity NOUN bam-1807 190 18 and and CCONJ bam-1807 190 19 energy energy NOUN bam-1807 190 20 availability availability NOUN bam-1807 190 21 are be AUX bam-1807 190 22 also also ADV bam-1807 190 23 accomplished accomplish VERB bam-1807 190 24 by by ADP bam-1807 190 25 increasing increase VERB bam-1807 190 26 skeletal skeletal ADJ bam-1807 190 27 muscle muscle NOUN bam-1807 190 28 blood blood NOUN bam-1807 190 29 flow flow NOUN bam-1807 190 30 capacity capacity NOUN bam-1807 190 31 . . PUNCT bam-1807 191 1 in in ADP bam-1807 191 2 fact fact NOUN bam-1807 191 3 , , PUNCT bam-1807 191 4 the the DET bam-1807 191 5 capillary capillary ADJ bam-1807 191 6 / / SYM bam-1807 191 7 muscle muscle NOUN bam-1807 191 8 interface interface NOUN bam-1807 191 9 may may AUX bam-1807 191 10 represent represent VERB bam-1807 191 11 a a DET bam-1807 191 12 limiting limit VERB bam-1807 191 13 factor factor NOUN bam-1807 191 14 for for ADP bam-1807 191 15 oxygen oxygen NOUN bam-1807 191 16 delivery delivery NOUN bam-1807 191 17 and and CCONJ bam-1807 191 18 , , PUNCT bam-1807 191 19 hence hence ADV bam-1807 191 20 , , PUNCT bam-1807 191 21 muscle muscle NOUN bam-1807 191 22 aerobic aerobic ADJ bam-1807 191 23 capacity capacity NOUN bam-1807 191 24 . . PUNCT bam-1807 192 1 laughlin laughlin PROPN bam-1807 192 2 and and CCONJ bam-1807 192 3 his his PRON bam-1807 192 4 group group NOUN bam-1807 192 5 ( ( PUNCT bam-1807 192 6 summarized summarize VERB bam-1807 192 7 in in ADP bam-1807 192 8 [ [ X bam-1807 192 9 60 60 NUM bam-1807 192 10 ] ] PUNCT bam-1807 192 11 ) ) PUNCT bam-1807 192 12 showed show VERB bam-1807 192 13 that that SCONJ bam-1807 192 14 at at ADV bam-1807 192 15 least least ADV bam-1807 192 16 two two NUM bam-1807 192 17 primary primary ADJ bam-1807 192 18 mechanisms mechanism NOUN bam-1807 192 19 determine determine VERB bam-1807 192 20 the the DET bam-1807 192 21 vascular vascular ADJ bam-1807 192 22 adaptative adaptative ADJ bam-1807 192 23 mechanisms mechanism NOUN bam-1807 192 24 contributing contribute VERB bam-1807 192 25 to to ADP bam-1807 192 26 increases increase NOUN bam-1807 192 27 in in ADP bam-1807 192 28 blood blood NOUN bam-1807 192 29 flow flow NOUN bam-1807 192 30 capacity capacity NOUN bam-1807 192 31 : : PUNCT bam-1807 192 32 1 1 X bam-1807 192 33 ) ) PUNCT bam-1807 192 34 structural structural ADJ bam-1807 192 35 remodeling remodeling NOUN bam-1807 192 36 of of ADP bam-1807 192 37 the the DET bam-1807 192 38 vascular vascular ADJ bam-1807 192 39 tree tree NOUN bam-1807 192 40 ( ( PUNCT bam-1807 192 41 capillary capillary ADJ bam-1807 192 42 bed bed NOUN bam-1807 192 43 and and CCONJ bam-1807 192 44 arterial arterial NOUN bam-1807 192 45 tree tree NOUN bam-1807 192 46 ) ) PUNCT bam-1807 192 47 and and CCONJ bam-1807 192 48 2 2 NUM bam-1807 192 49 ) ) PUNCT bam-1807 192 50 altered alter VERB bam-1807 192 51 vasomotor vasomotor NOUN bam-1807 192 52 reactivity reactivity NOUN bam-1807 192 53 of of ADP bam-1807 192 54 arteries artery NOUN bam-1807 192 55 and and CCONJ bam-1807 192 56 arterioles arterioles PROPN bam-1807 192 57 ; ; PUNCT bam-1807 192 58 i.e. i.e. X bam-1807 192 59 altered altered ADJ bam-1807 192 60 control control NOUN bam-1807 192 61 of of ADP bam-1807 192 62 conductance conductance NOUN bam-1807 192 63 . . PUNCT bam-1807 193 1 by by ADP bam-1807 193 2 exploiting exploit VERB bam-1807 193 3 the the DET bam-1807 193 4 fact fact NOUN bam-1807 193 5 that that SCONJ bam-1807 193 6 gastrocnemius gastrocnemius NOUN bam-1807 193 7 muscle muscle NOUN bam-1807 193 8 comprises comprise VERB bam-1807 193 9 distinct distinct ADJ bam-1807 193 10 slow slow ADJ bam-1807 193 11 / / SYM bam-1807 193 12 oxidative oxidative ADJ bam-1807 193 13 and and CCONJ bam-1807 193 14 fast fast ADJ bam-1807 193 15 / / SYM bam-1807 193 16 glycolytic glycolytic ADJ bam-1807 193 17 regions region NOUN bam-1807 193 18 , , PUNCT bam-1807 193 19 they they PRON bam-1807 193 20 analyzed analyze VERB bam-1807 193 21 the the DET bam-1807 193 22 effects effect NOUN bam-1807 193 23 of of ADP bam-1807 193 24 different different ADJ bam-1807 193 25 types type NOUN bam-1807 193 26 of of ADP bam-1807 193 27 exercise exercise NOUN bam-1807 193 28 training training NOUN bam-1807 193 29 on on ADP bam-1807 193 30 capillarity capillarity NOUN bam-1807 193 31 in in ADP bam-1807 193 32 the the DET bam-1807 193 33 different different ADJ bam-1807 193 34 regions region NOUN bam-1807 193 35 of of ADP bam-1807 193 36 the the DET bam-1807 193 37 gastrocnemius gastrocnemius NOUN bam-1807 193 38 muscle muscle NOUN bam-1807 193 39 and and CCONJ bam-1807 193 40 showed show VERB bam-1807 193 41 that that SCONJ bam-1807 193 42 exercise exercise NOUN bam-1807 193 43 training training NOUN bam-1807 193 44 - - PUNCT bam-1807 193 45 induced induce VERB bam-1807 193 46 adaptations adaptation NOUN bam-1807 193 47 of of ADP bam-1807 193 48 capillarity capillarity NOUN bam-1807 193 49 and and CCONJ bam-1807 193 50 mitochondrial mitochondrial ADJ bam-1807 193 51 content content NOUN bam-1807 193 52 are be AUX bam-1807 193 53 spatially spatially ADV bam-1807 193 54 coupled couple VERB bam-1807 193 55 , , PUNCT bam-1807 193 56 so so SCONJ bam-1807 193 57 that that SCONJ bam-1807 193 58 the the DET bam-1807 193 59 regions region NOUN bam-1807 193 60 that that PRON bam-1807 193 61 exhibit exhibit VERB bam-1807 193 62 increased increase VERB bam-1807 193 63 oxidative oxidative ADJ bam-1807 193 64 capacity capacity NOUN bam-1807 193 65 also also ADV bam-1807 193 66 exhibit exhibit VERB bam-1807 193 67 increased increase VERB bam-1807 193 68 capillarity capillarity NOUN bam-1807 193 69 . . PUNCT bam-1807 194 1 that that PRON bam-1807 194 2 is be AUX bam-1807 194 3 , , PUNCT bam-1807 194 4 endurance endurance ADJ bam-1807 194 5 training training NOUN bam-1807 194 6 increases increase VERB bam-1807 194 7 capillarity capillarity NOUN bam-1807 194 8 in in ADP bam-1807 194 9 high high ADJ bam-1807 194 10 oxidative oxidative ADJ bam-1807 194 11 skeletal skeletal ADJ bam-1807 194 12 muscle muscle NOUN bam-1807 194 13 , , PUNCT bam-1807 194 14 but but CCONJ bam-1807 194 15 not not PART bam-1807 194 16 in in ADP bam-1807 194 17 low low ADJ bam-1807 194 18 oxidative oxidative ADJ bam-1807 194 19 muscle muscle NOUN bam-1807 194 20 . . PUNCT bam-1807 195 1 in in ADP bam-1807 195 2 contrast contrast NOUN bam-1807 195 3 , , PUNCT bam-1807 195 4 interval interval NOUN bam-1807 195 5 sprint sprint NOUN bam-1807 195 6 training training NOUN bam-1807 195 7 increases increase VERB bam-1807 195 8 capillarity capillarity NOUN bam-1807 195 9 in in ADP bam-1807 195 10 fast fast ADJ bam-1807 195 11 / / SYM bam-1807 195 12 glycolytic glycolytic ADJ bam-1807 195 13 regions region NOUN bam-1807 195 14 but but CCONJ bam-1807 195 15 not not PART bam-1807 195 16 in in ADP bam-1807 195 17 high high ADJ bam-1807 195 18 oxidative oxidative ADJ bam-1807 195 19 muscle muscle NOUN bam-1807 195 20 tissue tissue NOUN bam-1807 195 21 . . PUNCT bam-1807 196 1 they they PRON bam-1807 196 2 went go VERB bam-1807 196 3 on on ADP bam-1807 196 4 to to PART bam-1807 196 5 demonstrate demonstrate VERB bam-1807 196 6 that that SCONJ bam-1807 196 7 increases increase VERB bam-1807 196 8 in in ADP bam-1807 196 9 blood blood NOUN bam-1807 196 10 flow flow NOUN bam-1807 196 11 capacity capacity NOUN bam-1807 196 12 are be AUX bam-1807 196 13 not not PART bam-1807 196 14 mediated mediate VERB bam-1807 196 15 solely solely ADV bam-1807 196 16 by by ADP bam-1807 196 17 increased increase VERB bam-1807 196 18 capillarization capillarization NOUN bam-1807 196 19 but but CCONJ bam-1807 196 20 also also ADV bam-1807 196 21 by by ADP bam-1807 196 22 changes change NOUN bam-1807 196 23 in in ADP bam-1807 196 24 control control NOUN bam-1807 196 25 of of ADP bam-1807 196 26 vascular vascular ADJ bam-1807 196 27 conductance conductance NOUN bam-1807 196 28 , , PUNCT bam-1807 196 29 due due ADP bam-1807 196 30 to to ADP bam-1807 196 31 alterations alteration NOUN bam-1807 196 32 in in ADP bam-1807 196 33 endothelial endothelial ADJ bam-1807 196 34 and and CCONJ bam-1807 196 35 smooth smooth ADJ bam-1807 196 36 muscle muscle NOUN bam-1807 196 37 phenotypes phenotype NOUN bam-1807 196 38 and and CCONJ bam-1807 196 39 altered alter VERB bam-1807 196 40 control control NOUN bam-1807 196 41 of of ADP bam-1807 196 42 vascular vascular ADJ bam-1807 196 43 resistance resistance NOUN bam-1807 196 44 . . PUNCT bam-1807 197 1 the the DET bam-1807 197 2 process process NOUN bam-1807 197 3 of of ADP bam-1807 197 4 vascular vascular ADJ bam-1807 197 5 remodeling remodeling NOUN bam-1807 197 6 has have AUX bam-1807 197 7 been be AUX bam-1807 197 8 recently recently ADV bam-1807 197 9 reviewed review VERB bam-1807 197 10 by by ADP bam-1807 197 11 egginton egginton PROPN bam-1807 197 12 [ [ X bam-1807 197 13 26 26 NUM bam-1807 197 14 ] ] PUNCT bam-1807 197 15 . . PUNCT bam-1807 198 1 angiogenesis angiogenesis NOUN bam-1807 198 2 involves involve VERB bam-1807 198 3 proliferation proliferation NOUN bam-1807 198 4 and and CCONJ bam-1807 198 5 migration migration NOUN bam-1807 198 6 of of ADP bam-1807 198 7 endothelial endothelial ADJ bam-1807 198 8 cells cell NOUN bam-1807 198 9 to to PART bam-1807 198 10 form form VERB bam-1807 198 11 new new ADJ bam-1807 198 12 capillaries capillary NOUN bam-1807 198 13 from from ADP bam-1807 198 14 pre pre ADJ bam-1807 198 15 - - ADJ bam-1807 198 16 existing existing ADJ bam-1807 198 17 ones one NOUN bam-1807 198 18 . . PUNCT bam-1807 199 1 it it PRON bam-1807 199 2 occurs occur VERB bam-1807 199 3 by by ADP bam-1807 199 4 different different ADJ bam-1807 199 5 ways way NOUN bam-1807 199 6 in in ADP bam-1807 199 7 different different ADJ bam-1807 199 8 physiological physiological ADJ bam-1807 199 9 circumstances circumstance NOUN bam-1807 199 10 , , PUNCT bam-1807 199 11 and and CCONJ bam-1807 199 12 it it PRON bam-1807 199 13 is be AUX bam-1807 199 14 believed believe VERB bam-1807 199 15 to to PART bam-1807 199 16 occur occur VERB bam-1807 199 17 as as ADP bam-1807 199 18 a a DET bam-1807 199 19 consequence consequence NOUN bam-1807 199 20 of of ADP bam-1807 199 21 exercise exercise NOUN bam-1807 199 22 as as ADP bam-1807 199 23 a a DET bam-1807 199 24 result result NOUN bam-1807 199 25 of of ADP bam-1807 199 26 mechanical mechanical ADJ bam-1807 199 27 factors factor NOUN bam-1807 199 28 and and CCONJ bam-1807 199 29 of of ADP bam-1807 199 30 the the DET bam-1807 199 31 activation activation NOUN bam-1807 199 32 of of ADP bam-1807 199 33 a a DET bam-1807 199 34 number number NOUN bam-1807 199 35 of of ADP bam-1807 199 36 signaling signal VERB bam-1807 199 37 pathways pathway NOUN bam-1807 199 38 . . PUNCT bam-1807 200 1 also also ADV bam-1807 200 2 arteriogenesis arteriogenesis PROPN bam-1807 200 3 , , PUNCT bam-1807 200 4 involving involve VERB bam-1807 200 5 the the DET bam-1807 200 6 remodeling remodeling NOUN bam-1807 200 7 of of ADP bam-1807 200 8 existing exist VERB bam-1807 200 9 arterial arterial ADJ bam-1807 200 10 vessels vessel NOUN bam-1807 200 11 , , PUNCT bam-1807 200 12 may may AUX bam-1807 200 13 play play VERB bam-1807 200 14 a a DET bam-1807 200 15 role role NOUN bam-1807 200 16 in in ADP bam-1807 200 17 exercise exercise NOUN bam-1807 200 18 - - PUNCT bam-1807 200 19 induced induce VERB bam-1807 200 20 vascular vascular ADJ bam-1807 200 21 remodeling remodeling NOUN bam-1807 200 22 , , PUNCT bam-1807 200 23 and and CCONJ bam-1807 200 24 may may AUX bam-1807 200 25 share share VERB bam-1807 200 26 many many ADJ bam-1807 200 27 of of ADP bam-1807 200 28 the the DET bam-1807 200 29 growth growth NOUN bam-1807 200 30 factors factor NOUN bam-1807 200 31 advocated advocate VERB bam-1807 200 32 in in ADP bam-1807 200 33 angiogenesis angiogenesis NOUN bam-1807 200 34 . . PUNCT bam-1807 201 1 exercise exercise NOUN bam-1807 201 2 modulates modulate VERB bam-1807 201 3 the the DET bam-1807 201 4 vasomotor vasomotor NOUN bam-1807 201 5 tone tone NOUN bam-1807 201 6 , , PUNCT bam-1807 201 7 which which PRON bam-1807 201 8 , , PUNCT bam-1807 201 9 in in ADP bam-1807 201 10 turn turn NOUN bam-1807 201 11 , , PUNCT bam-1807 201 12 affects affect VERB bam-1807 201 13 vasodilation vasodilation NOUN bam-1807 201 14 , , PUNCT bam-1807 201 15 by by ADP bam-1807 201 16 promoting promote VERB bam-1807 201 17 the the DET bam-1807 201 18 release release NOUN bam-1807 201 19 of of ADP bam-1807 201 20 adenosine adenosine NOUN bam-1807 201 21 and and CCONJ bam-1807 201 22 , , PUNCT bam-1807 201 23 possibly possibly ADV bam-1807 201 24 , , PUNCT bam-1807 201 25 nitric nitric ADJ bam-1807 201 26 oxide oxide NOUN bam-1807 201 27 . . PUNCT bam-1807 202 1 shear shear NOUN bam-1807 202 2 stress stress NOUN bam-1807 202 3 , , PUNCT bam-1807 202 4 transmural transmural ADJ bam-1807 202 5 pressure pressure NOUN bam-1807 202 6 and and CCONJ bam-1807 202 7 cyclic cyclic ADJ bam-1807 202 8 stretch stretch NOUN bam-1807 202 9 activate activate VERB bam-1807 202 10 mechanotransduction mechanotransduction NOUN bam-1807 202 11 mechanisms mechanism NOUN bam-1807 202 12 mediated mediate VERB bam-1807 202 13 by by ADP bam-1807 202 14 integrins integrin NOUN bam-1807 202 15 and and CCONJ bam-1807 202 16 associated associate VERB bam-1807 202 17 gtpases gtpase NOUN bam-1807 202 18 . . PUNCT bam-1807 203 1 the the DET bam-1807 203 2 signal signal ADJ bam-1807 203 3 transduction transduction NOUN bam-1807 203 4 pathways pathway NOUN bam-1807 203 5 thus thus ADV bam-1807 203 6 stimulated stimulate VERB bam-1807 203 7 , , PUNCT bam-1807 203 8 which which PRON bam-1807 203 9 recruit recruit VERB bam-1807 203 10 different different ADJ bam-1807 203 11 kinases kinase NOUN bam-1807 203 12 , , PUNCT bam-1807 203 13 result result VERB bam-1807 203 14 in in ADP bam-1807 203 15 the the DET bam-1807 203 16 promotion promotion NOUN bam-1807 203 17 of of ADP bam-1807 203 18 angiogenesis angiogenesis NOUN bam-1807 203 19 . . PUNCT bam-1807 204 1 the the DET bam-1807 204 2 major major ADJ bam-1807 204 3 player player NOUN bam-1807 204 4 of of ADP bam-1807 204 5 angiogenic angiogenic ADJ bam-1807 204 6 processes process NOUN bam-1807 204 7 is be AUX bam-1807 204 8 the the DET bam-1807 204 9 vascular vascular ADJ bam-1807 204 10 endothelial endothelial ADJ bam-1807 204 11 growth growth NOUN bam-1807 204 12 factor factor NOUN bam-1807 204 13 , , PUNCT bam-1807 204 14 vegf vegf PROPN bam-1807 204 15 . . PUNCT bam-1807 205 1 vegf vegf PROPN bam-1807 205 2 , , PUNCT bam-1807 205 3 produced produce VERB bam-1807 205 4 by by ADP bam-1807 205 5 the the DET bam-1807 205 6 endothelial endothelial ADJ bam-1807 205 7 cells cell NOUN bam-1807 205 8 , , PUNCT bam-1807 205 9 perivascular perivascular ADJ bam-1807 205 10 cells cell NOUN bam-1807 205 11 and and CCONJ bam-1807 205 12 the the DET bam-1807 205 13 host host NOUN bam-1807 205 14 cells cell NOUN bam-1807 205 15 , , PUNCT bam-1807 205 16 such such ADJ bam-1807 205 17 as as ADP bam-1807 205 18 skeletal skeletal ADJ bam-1807 205 19 muscle muscle NOUN bam-1807 205 20 cells cell NOUN bam-1807 205 21 , , PUNCT bam-1807 205 22 is be AUX bam-1807 205 23 the the DET bam-1807 205 24 ligand ligand NOUN bam-1807 205 25 of of ADP bam-1807 205 26 three three NUM bam-1807 205 27 different different ADJ bam-1807 205 28 receptor receptor NOUN bam-1807 205 29 tyrosine tyrosine NOUN bam-1807 205 30 kinases kinase NOUN bam-1807 205 31 , , PUNCT bam-1807 205 32 localized localize VERB bam-1807 205 33 on on ADP bam-1807 205 34 the the DET bam-1807 205 35 endothelial endothelial ADJ bam-1807 205 36 cells cell NOUN bam-1807 205 37 . . PUNCT bam-1807 206 1 ligation ligation NOUN bam-1807 206 2 of of ADP bam-1807 206 3 vegf vegf PROPN bam-1807 206 4 on on ADP bam-1807 206 5 its its PRON bam-1807 206 6 receptors receptor NOUN bam-1807 206 7 initiates initiate VERB bam-1807 206 8 a a DET bam-1807 206 9 signaling signal VERB bam-1807 206 10 cascade cascade NOUN bam-1807 206 11 that that PRON bam-1807 206 12 includes include VERB bam-1807 206 13 the the DET bam-1807 206 14 activation activation NOUN bam-1807 206 15 of of ADP bam-1807 206 16 pi3k pi3k PROPN bam-1807 206 17 , , PUNCT bam-1807 206 18 plcγ plcγ NOUN bam-1807 206 19 and and CCONJ bam-1807 206 20 pkc pkc NOUN bam-1807 206 21 . . PUNCT bam-1807 207 1 in in ADP bam-1807 207 2 turn turn NOUN bam-1807 207 3 , , PUNCT bam-1807 207 4 vegf vegf PROPN bam-1807 207 5 is be AUX bam-1807 207 6 positively positively ADV bam-1807 207 7 controlled control VERB bam-1807 207 8 by by ADP bam-1807 207 9 different different ADJ bam-1807 207 10 cytokines cytokine NOUN bam-1807 207 11 , , PUNCT bam-1807 207 12 growth growth NOUN bam-1807 207 13 factors factor NOUN bam-1807 207 14 and and CCONJ bam-1807 207 15 hypoxia hypoxia NOUN bam-1807 207 16 , , PUNCT bam-1807 207 17 through through ADP bam-1807 207 18 the the DET bam-1807 207 19 activation activation NOUN bam-1807 207 20 of of ADP bam-1807 207 21 hif-1α hif-1α NOUN bam-1807 207 22 [ [ X bam-1807 207 23 65 65 NUM bam-1807 207 24 ] ] PUNCT bam-1807 207 25 . . PUNCT bam-1807 208 1 it it PRON bam-1807 208 2 appears appear VERB bam-1807 208 3 that that SCONJ bam-1807 208 4 hif hif PROPN bam-1807 208 5 is be AUX bam-1807 208 6 involved involve VERB bam-1807 208 7 in in ADP bam-1807 208 8 stretchbut stretchbut NOUN bam-1807 208 9 not not PART bam-1807 208 10 in in ADP bam-1807 208 11 shearinduced shearinduce VERB bam-1807 208 12 angiogenesis angiogenesis NOUN bam-1807 208 13 [ [ X bam-1807 208 14 25 25 NUM bam-1807 208 15 ] ] PUNCT bam-1807 208 16 . . PUNCT bam-1807 209 1 the the DET bam-1807 209 2 effects effect NOUN bam-1807 209 3 of of ADP bam-1807 209 4 vegf vegf PROPN bam-1807 209 5 are be AUX bam-1807 209 6 mediated mediate VERB bam-1807 209 7 by by ADP bam-1807 209 8 nitric nitric ADJ bam-1807 209 9 oxide oxide NOUN bam-1807 209 10 ( ( PUNCT bam-1807 209 11 no no NOUN bam-1807 209 12 ) ) PUNCT bam-1807 209 13 and and CCONJ bam-1807 209 14 prostaglandins prostaglandin NOUN bam-1807 209 15 that that PRON bam-1807 209 16 contribute contribute VERB bam-1807 209 17 to to ADP bam-1807 209 18 vascular vascular ADJ bam-1807 209 19 dilation dilation NOUN bam-1807 209 20 . . PUNCT bam-1807 210 1 no no PRON bam-1807 210 2 seems seem VERB bam-1807 210 3 to to PART bam-1807 210 4 be be AUX bam-1807 210 5 involved involve VERB bam-1807 210 6 in in ADP bam-1807 210 7 shear- shear- PROPN bam-1807 210 8 , , PUNCT bam-1807 210 9 but but CCONJ bam-1807 210 10 not not PART bam-1807 210 11 in in ADP bam-1807 210 12 stretchinduced stretchinduce VERB bam-1807 210 13 angiogenesis angiogenesis NOUN bam-1807 211 1 [ [ X bam-1807 211 2 25 25 NUM bam-1807 211 3 ] ] PUNCT bam-1807 211 4 . . PUNCT bam-1807 212 1 other other ADJ bam-1807 212 2 angiogenic angiogenic ADJ bam-1807 212 3 or or CCONJ bam-1807 212 4 proangiogenic proangiogenic ADJ bam-1807 212 5 factors factor NOUN bam-1807 212 6 , , PUNCT bam-1807 212 7 such such ADJ bam-1807 212 8 as as ADP bam-1807 212 9 fgf fgf PROPN bam-1807 212 10 , , PUNCT bam-1807 212 11 pdgf pdgf PROPN bam-1807 212 12 and and CCONJ bam-1807 212 13 tgf tgf PROPN bam-1807 212 14 - - PUNCT bam-1807 212 15 β β PROPN bam-1807 212 16 , , PUNCT bam-1807 212 17 do do AUX bam-1807 212 18 not not PART bam-1807 212 19 appear appear VERB bam-1807 212 20 to to PART bam-1807 212 21 be be AUX bam-1807 212 22 upregulated upregulate VERB bam-1807 212 23 by by ADP bam-1807 212 24 exercise exercise NOUN bam-1807 212 25 . . PUNCT bam-1807 213 1 exercise exercise NOUN bam-1807 213 2 upregulates upregulate VERB bam-1807 213 3 vegf vegf PROPN bam-1807 213 4 mrna mrna PROPN bam-1807 213 5 and and CCONJ bam-1807 213 6 protein protein NOUN bam-1807 213 7 , , PUNCT bam-1807 213 8 as as ADV bam-1807 213 9 well well ADV bam-1807 213 10 as as ADP bam-1807 213 11 the the DET bam-1807 213 12 expression expression NOUN bam-1807 213 13 of of ADP bam-1807 213 14 vegfr1 vegfr1 NOUN bam-1807 213 15 and and CCONJ bam-1807 213 16 2 2 NUM bam-1807 213 17 , , PUNCT bam-1807 213 18 in in ADP bam-1807 213 19 muscle muscle NOUN bam-1807 213 20 . . PUNCT bam-1807 214 1 vegf vegf PROPN bam-1807 214 2 is be AUX bam-1807 214 3 also also ADV bam-1807 214 4 mobilized mobilize VERB bam-1807 214 5 and and CCONJ bam-1807 214 6 released release VERB bam-1807 214 7 by by ADP bam-1807 214 8 active active ADJ bam-1807 214 9 muscle muscle NOUN bam-1807 214 10 , , PUNCT bam-1807 214 11 thus thus ADV bam-1807 214 12 determining determine VERB bam-1807 214 13 an an DET bam-1807 214 14 increase increase NOUN bam-1807 214 15 in in ADP bam-1807 214 16 circulating circulate VERB bam-1807 214 17 vegf vegf PROPN bam-1807 214 18 after after ADP bam-1807 214 19 acute acute ADJ bam-1807 214 20 exercise exercise NOUN bam-1807 214 21 [ [ X bam-1807 214 22 57 57 NUM bam-1807 214 23 ] ] PUNCT bam-1807 214 24 . . PUNCT bam-1807 215 1 however however ADV bam-1807 215 2 , , PUNCT bam-1807 215 3 data datum NOUN bam-1807 215 4 evidentiate evidentiate VERB bam-1807 215 5 the the DET bam-1807 215 6 existence existence NOUN bam-1807 215 7 of of ADP bam-1807 215 8 a a DET bam-1807 215 9 complex complex ADJ bam-1807 215 10 relationship relationship NOUN bam-1807 215 11 between between ADP bam-1807 215 12 vegf vegf PROPN bam-1807 215 13 mrna mrna PROPN bam-1807 215 14 and and CCONJ bam-1807 215 15 protein protein NOUN bam-1807 215 16 levels level NOUN bam-1807 215 17 as as ADV bam-1807 215 18 well well ADV bam-1807 215 19 as as ADP bam-1807 215 20 in in ADP bam-1807 215 21 vegf vegf PROPN bam-1807 215 22 levels level NOUN bam-1807 215 23 after after ADP bam-1807 215 24 a a DET bam-1807 215 25 single single ADJ bam-1807 215 26 bout bout NOUN bam-1807 215 27 of of ADP bam-1807 215 28 exercise exercise NOUN bam-1807 215 29 or or CCONJ bam-1807 215 30 following follow VERB bam-1807 215 31 exercise exercise NOUN bam-1807 215 32 training training NOUN bam-1807 215 33 ( ( PUNCT bam-1807 215 34 discussed discuss VERB bam-1807 215 35 in in ADP bam-1807 215 36 [ [ X bam-1807 215 37 10 10 NUM bam-1807 215 38 ] ] NUM bam-1807 215 39 ) ) PUNCT bam-1807 215 40 . . PUNCT bam-1807 216 1 also also ADV bam-1807 216 2 proteolytic proteolytic VERB bam-1807 216 3 modification modification NOUN bam-1807 216 4 of of ADP bam-1807 216 5 the the DET bam-1807 216 6 extracellular extracellular ADJ bam-1807 216 7 matrix matrix NOUN bam-1807 216 8 , , PUNCT bam-1807 216 9 induced induce VERB bam-1807 216 10 by by ADP bam-1807 216 11 mechanical mechanical ADJ bam-1807 216 12 deformation deformation NOUN bam-1807 216 13 during during ADP bam-1807 216 14 cyclical cyclical ADJ bam-1807 216 15 contractions contraction NOUN bam-1807 216 16 or or CCONJ bam-1807 216 17 muscle muscle NOUN bam-1807 216 18 overload overload NOUN bam-1807 216 19 , , PUNCT bam-1807 216 20 are be AUX bam-1807 216 21 involved involve VERB bam-1807 216 22 in in ADP bam-1807 216 23 vascular vascular ADJ bam-1807 216 24 remodeling remodeling NOUN bam-1807 216 25 . . PUNCT bam-1807 217 1 in in ADP bam-1807 217 2 particular particular ADJ bam-1807 217 3 , , PUNCT bam-1807 217 4 proteolysis proteolysis NOUN bam-1807 217 5 of of ADP bam-1807 217 6 the the DET bam-1807 217 7 basement basement NOUN bam-1807 217 8 membrane membrane NOUN bam-1807 217 9 is be AUX bam-1807 217 10 necessary necessary ADJ bam-1807 217 11 for for ADP bam-1807 217 12 capillary capillary ADJ bam-1807 217 13 sprouting sprouting NOUN bam-1807 217 14 and and CCONJ bam-1807 217 15 is be AUX bam-1807 217 16 carried carry VERB bam-1807 217 17 out out ADP bam-1807 217 18 by by ADP bam-1807 217 19 matrix matrix NOUN bam-1807 217 20 metalloproteinases metalloproteinase NOUN bam-1807 217 21 and and CCONJ bam-1807 217 22 other other ADJ bam-1807 217 23 enzymes enzyme NOUN bam-1807 217 24 ( ( PUNCT bam-1807 217 25 plasminogen plasminogen NOUN bam-1807 217 26 and and CCONJ bam-1807 217 27 the the DET bam-1807 217 28 urokinase urokinase NOUN bam-1807 217 29 and and CCONJ bam-1807 217 30 tissue tissue NOUN bam-1807 217 31 plasminogen plasminogen NOUN bam-1807 217 32 activators activator NOUN bam-1807 217 33 ) ) PUNCT bam-1807 217 34 . . PUNCT bam-1807 218 1 the the DET bam-1807 218 2 process process NOUN bam-1807 218 3 of of ADP bam-1807 218 4 extracellular extracellular ADJ bam-1807 218 5 matrix matrix NOUN bam-1807 218 6 degradation degradation NOUN bam-1807 218 7 must must AUX bam-1807 218 8 be be AUX bam-1807 218 9 strictly strictly ADV bam-1807 218 10 controlled control VERB bam-1807 218 11 and and CCONJ bam-1807 218 12 coordinated coordinate VERB bam-1807 218 13 with with ADP bam-1807 218 14 the the DET bam-1807 218 15 angiogenic angiogenic ADJ bam-1807 218 16 one one NUM bam-1807 218 17 [ [ X bam-1807 218 18 89 89 NUM bam-1807 218 19 ] ] PUNCT bam-1807 218 20 . . PUNCT bam-1807 219 1 as as SCONJ bam-1807 219 2 pointed point VERB bam-1807 219 3 out out ADP bam-1807 219 4 above above ADV bam-1807 219 5 , , PUNCT bam-1807 219 6 angiogenesis angiogenesis NOUN bam-1807 219 7 is be AUX bam-1807 219 8 mostly mostly ADV bam-1807 219 9 induced induce VERB bam-1807 219 10 by by ADP bam-1807 219 11 endurance endurance NOUN bam-1807 219 12 training training NOUN bam-1807 219 13 , , PUNCT bam-1807 219 14 and and CCONJ bam-1807 219 15 is be AUX bam-1807 219 16 instrumental instrumental ADJ bam-1807 219 17 to to ADP bam-1807 219 18 the the DET bam-1807 219 19 increase increase NOUN bam-1807 219 20 in in ADP bam-1807 219 21 muscle muscle NOUN bam-1807 219 22 oxidative oxidative ADJ bam-1807 219 23 capacity capacity NOUN bam-1807 219 24 . . PUNCT bam-1807 220 1 in in ADP bam-1807 220 2 contrast contrast NOUN bam-1807 220 3 , , PUNCT bam-1807 220 4 usually usually ADV bam-1807 220 5 no no DET bam-1807 220 6 angiogenesis angiogenesis NOUN bam-1807 220 7 occurs occur VERB bam-1807 220 8 as as ADP bam-1807 220 9 a a DET bam-1807 220 10 consequence consequence NOUN bam-1807 220 11 of of ADP bam-1807 220 12 strength strength NOUN bam-1807 220 13 training training NOUN bam-1807 220 14 , , PUNCT bam-1807 220 15 where where SCONJ bam-1807 220 16 also also ADV bam-1807 220 17 mitochondrial mitochondrial ADJ bam-1807 220 18 volume volume NOUN bam-1807 220 19 density density NOUN bam-1807 220 20 decreases decrease VERB bam-1807 220 21 in in ADP bam-1807 220 22 proportion proportion NOUN bam-1807 220 23 to to ADP bam-1807 220 24 muscle muscle NOUN bam-1807 220 25 hypertrophy hypertrophy NOUN bam-1807 220 26 . . PUNCT bam-1807 221 1 6 6 X bam-1807 221 2 . . X bam-1807 221 3 adaptation adaptation NOUN bam-1807 221 4 of of ADP bam-1807 221 5 conductive conductive ADJ bam-1807 221 6 apparatus apparatus NOUN bam-1807 221 7 , , PUNCT bam-1807 221 8 sarcoplasmic sarcoplasmic NOUN bam-1807 221 9 reticulum reticulum NOUN bam-1807 221 10 and and CCONJ bam-1807 221 11 other other ADJ bam-1807 221 12 systems system NOUN bam-1807 221 13 in in ADP bam-1807 221 14 a a DET bam-1807 221 15 normal normal ADJ bam-1807 221 16 muscle muscle NOUN bam-1807 221 17 fiber fiber NOUN bam-1807 221 18 , , PUNCT bam-1807 221 19 action action NOUN bam-1807 221 20 potentials potential VERB bam-1807 221 21 lead lead VERB bam-1807 221 22 to to ADP bam-1807 221 23 the the DET bam-1807 221 24 depolarization depolarization NOUN bam-1807 221 25 of of ADP bam-1807 221 26 the the DET bam-1807 221 27 sarcolemma sarcolemma NOUN bam-1807 221 28 , , PUNCT bam-1807 221 29 which which PRON bam-1807 221 30 propagates propagate VERB bam-1807 221 31 down down ADP bam-1807 221 32 the the DET bam-1807 221 33 transverse transverse NOUN bam-1807 221 34 tubules tubule NOUN bam-1807 221 35 ( ( PUNCT bam-1807 221 36 t t NOUN bam-1807 221 37 - - PUNCT bam-1807 221 38 tubules tubule NOUN bam-1807 221 39 ) ) PUNCT bam-1807 221 40 and and CCONJ bam-1807 221 41 activates activate VERB bam-1807 221 42 voltage voltage NOUN bam-1807 221 43 - - PUNCT bam-1807 221 44 gated gate VERB bam-1807 221 45 cav1.1 cav1.1 NOUN bam-1807 221 46 ca2 ca2 PROPN bam-1807 221 47 + + NOUN bam-1807 221 48 channels channel NOUN bam-1807 221 49 ( ( PUNCT bam-1807 221 50 also also ADV bam-1807 221 51 known know VERB bam-1807 221 52 as as ADP bam-1807 221 53 ltype ltype NOUN bam-1807 221 54 ca2 ca2 PROPN bam-1807 221 55 + + PROPN bam-1807 221 56 channels channel NOUN bam-1807 221 57 or or CCONJ bam-1807 221 58 dihydropyridine dihydropyridine NOUN bam-1807 221 59 receptors receptor NOUN bam-1807 221 60 , , PUNCT bam-1807 221 61 dhprs dhprs NOUN bam-1807 221 62 ) ) PUNCT bam-1807 221 63 on on ADP bam-1807 221 64 the the DET bam-1807 221 65 t t NOUN bam-1807 221 66 - - PUNCT bam-1807 221 67 tubules tubule NOUN bam-1807 221 68 . . PUNCT bam-1807 222 1 voltage voltage NOUN bam-1807 222 2 - - PUNCT bam-1807 222 3 induced induce VERB bam-1807 222 4 conformational conformational ADJ bam-1807 222 5 changes change NOUN bam-1807 222 6 in in ADP bam-1807 222 7 dhprs dhprs ADJ bam-1807 222 8 activate activate NOUN bam-1807 222 9 , , PUNCT bam-1807 222 10 by by ADP bam-1807 222 11 some some DET bam-1807 222 12 physical physical ADJ bam-1807 222 13 interaction interaction NOUN bam-1807 222 14 , , PUNCT bam-1807 222 15 closely closely ADV bam-1807 222 16 apposed appose VERB bam-1807 222 17 ca2 ca2 PROPN bam-1807 222 18 + + CCONJ bam-1807 222 19 release release NOUN bam-1807 222 20 channels channel NOUN bam-1807 222 21 known know VERB bam-1807 222 22 as as ADP bam-1807 222 23 type type NOUN bam-1807 222 24 1 1 NUM bam-1807 222 25 ryanodine ryanodine NOUN bam-1807 222 26 receptors receptor NOUN bam-1807 222 27 ( ( PUNCT bam-1807 222 28 ryr1s ryr1s NOUN bam-1807 222 29 ) ) PUNCT bam-1807 222 30 on on ADP bam-1807 222 31 the the DET bam-1807 222 32 terminal terminal ADJ bam-1807 222 33 cisternae cisternae NOUN bam-1807 222 34 of of ADP bam-1807 222 35 the the DET bam-1807 222 36 sarcoplasmic sarcoplasmic NOUN bam-1807 222 37 reticulum reticulum NOUN bam-1807 222 38 ( ( PUNCT bam-1807 222 39 sr sr PROPN bam-1807 222 40 ) ) PUNCT bam-1807 222 41 . . PUNCT bam-1807 223 1 ca2 ca2 PROPN bam-1807 223 2 + + NOUN bam-1807 223 3 release release NOUN bam-1807 223 4 from from ADP bam-1807 223 5 the the DET bam-1807 223 6 sr sr PROPN bam-1807 223 7 through through ADP bam-1807 223 8 ryr1 ryr1 NOUN bam-1807 223 9 channels channel NOUN bam-1807 223 10 the the DET bam-1807 223 11 exercised exercise VERB bam-1807 223 12 skeletal skeletal ADJ bam-1807 223 13 muscle muscle NOUN bam-1807 223 14 european european PROPN bam-1807 223 15 journal journal PROPN bam-1807 223 16 translational translational ADJ bam-1807 223 17 myology myology NOUN bam-1807 223 18 myology myology NOUN bam-1807 223 19 reviews review VERB bam-1807 223 20 20 20 NUM bam-1807 223 21 ( ( PUNCT bam-1807 223 22 3 3 NUM bam-1807 223 23 ): ): PUNCT bam-1807 223 24 105 105 NUM bam-1807 223 25 - - SYM bam-1807 223 26 120 120 NUM bam-1807 223 27 , , PUNCT bam-1807 223 28 2010 2010 NUM bam-1807 223 29 112 112 NUM bam-1807 223 30 results result NOUN bam-1807 223 31 in in ADP bam-1807 223 32 a a DET bam-1807 223 33 large large ADJ bam-1807 223 34 and and CCONJ bam-1807 223 35 rapid rapid ADJ bam-1807 223 36 rise rise NOUN bam-1807 223 37 in in ADP bam-1807 223 38 cytoplasmic cytoplasmic ADJ bam-1807 223 39 [ [ X bam-1807 223 40 ca2 ca2 PROPN bam-1807 223 41 + + PROPN bam-1807 223 42 ] ] PUNCT bam-1807 223 43 to to ADP bam-1807 223 44 micromolar micromolar ADJ bam-1807 223 45 levels level NOUN bam-1807 223 46 . . PUNCT bam-1807 224 1 by by ADP bam-1807 224 2 binding bind VERB bam-1807 224 3 to to ADP bam-1807 224 4 troponin troponin PROPN bam-1807 224 5 c c PROPN bam-1807 224 6 , , PUNCT bam-1807 224 7 ca2 ca2 PROPN bam-1807 224 8 + + PROPN bam-1807 224 9 allows allow VERB bam-1807 224 10 myosin myosin NOUN bam-1807 224 11 and and CCONJ bam-1807 224 12 actin actin NOUN bam-1807 224 13 to to PART bam-1807 224 14 form form VERB bam-1807 224 15 cross cross ADJ bam-1807 224 16 - - NOUN bam-1807 224 17 bridges bridge NOUN bam-1807 224 18 , , PUNCT bam-1807 224 19 leading lead VERB bam-1807 224 20 to to ADP bam-1807 224 21 the the DET bam-1807 224 22 sliding sliding NOUN bam-1807 224 23 of of ADP bam-1807 224 24 actin actin NOUN bam-1807 224 25 and and CCONJ bam-1807 224 26 myosin myosin NOUN bam-1807 224 27 filaments filament NOUN bam-1807 224 28 with with ADP bam-1807 224 29 respect respect NOUN bam-1807 224 30 to to ADP bam-1807 224 31 each each DET bam-1807 224 32 other other ADJ bam-1807 224 33 and and CCONJ bam-1807 224 34 the the DET bam-1807 224 35 shortening shortening NOUN bam-1807 224 36 of of ADP bam-1807 224 37 the the DET bam-1807 224 38 sarcomere sarcomere NOUN bam-1807 224 39 . . PUNCT bam-1807 225 1 this this DET bam-1807 225 2 process process NOUN bam-1807 225 3 , , PUNCT bam-1807 225 4 known know VERB bam-1807 225 5 as as ADP bam-1807 225 6 excitationcontraction excitationcontraction NOUN bam-1807 225 7 ( ( PUNCT bam-1807 225 8 e e NOUN bam-1807 225 9 - - NOUN bam-1807 225 10 c c NOUN bam-1807 225 11 ) ) PUNCT bam-1807 225 12 coupling coupling NOUN bam-1807 225 13 , , PUNCT bam-1807 225 14 results result NOUN bam-1807 225 15 is be AUX bam-1807 225 16 force force NOUN bam-1807 225 17 generation generation NOUN bam-1807 225 18 and and CCONJ bam-1807 225 19 muscle muscle NOUN bam-1807 225 20 contraction contraction NOUN bam-1807 225 21 [ [ X bam-1807 225 22 24 24 NUM bam-1807 225 23 ] ] PUNCT bam-1807 225 24 . . PUNCT bam-1807 226 1 the the DET bam-1807 226 2 activity activity NOUN bam-1807 226 3 and and CCONJ bam-1807 226 4 the the DET bam-1807 226 5 status status NOUN bam-1807 226 6 of of ADP bam-1807 226 7 the the DET bam-1807 226 8 different different ADJ bam-1807 226 9 components component NOUN bam-1807 226 10 of of ADP bam-1807 226 11 the the DET bam-1807 226 12 excitation excitation NOUN bam-1807 226 13 - - PUNCT bam-1807 226 14 contraction contraction NOUN bam-1807 226 15 coupling coupling NOUN bam-1807 226 16 apparatus apparatus NOUN bam-1807 226 17 are be AUX bam-1807 226 18 modulated modulate VERB bam-1807 226 19 by by ADP bam-1807 226 20 a a DET bam-1807 226 21 number number NOUN bam-1807 226 22 of of ADP bam-1807 226 23 stable stable ADJ bam-1807 226 24 post post ADJ bam-1807 226 25 - - ADJ bam-1807 226 26 transcriptional transcriptional ADJ bam-1807 226 27 modifications modification NOUN bam-1807 226 28 , , PUNCT bam-1807 226 29 including include VERB bam-1807 226 30 phosphorylation phosphorylation NOUN bam-1807 226 31 , , PUNCT bam-1807 226 32 nitrosylation nitrosylation NOUN bam-1807 226 33 , , PUNCT bam-1807 226 34 and and CCONJ bam-1807 226 35 oxidation oxidation NOUN bam-1807 226 36 , , PUNCT bam-1807 226 37 that that PRON bam-1807 226 38 may may AUX bam-1807 226 39 be be AUX bam-1807 226 40 downstream downstream ADJ bam-1807 226 41 of of ADP bam-1807 226 42 stress stress NOUN bam-1807 226 43 - - PUNCT bam-1807 226 44 dependent dependent ADJ bam-1807 226 45 signaling signal VERB bam-1807 226 46 pathways pathway NOUN bam-1807 226 47 . . PUNCT bam-1807 227 1 in in ADP bam-1807 227 2 effect effect NOUN bam-1807 227 3 , , PUNCT bam-1807 227 4 repetitive repetitive ADJ bam-1807 227 5 strenuous strenuous ADJ bam-1807 227 6 muscle muscle NOUN bam-1807 227 7 contractions contraction NOUN bam-1807 227 8 may may AUX bam-1807 227 9 be be AUX bam-1807 227 10 a a DET bam-1807 227 11 source source NOUN bam-1807 227 12 of of ADP bam-1807 227 13 stress stress NOUN bam-1807 227 14 for for ADP bam-1807 227 15 all all DET bam-1807 227 16 the the DET bam-1807 227 17 cellular cellular ADJ bam-1807 227 18 components component NOUN bam-1807 227 19 involved involve VERB bam-1807 227 20 in in ADP bam-1807 227 21 force force NOUN bam-1807 227 22 generation generation NOUN bam-1807 227 23 . . PUNCT bam-1807 228 1 in in ADP bam-1807 228 2 particular particular ADJ bam-1807 228 3 , , PUNCT bam-1807 228 4 repeated repeat VERB bam-1807 228 5 cycles cycle NOUN bam-1807 228 6 of of ADP bam-1807 228 7 [ [ PUNCT bam-1807 228 8 ca2+]cyt ca2+]cyt PROPN bam-1807 228 9 increases increase NOUN bam-1807 228 10 may may AUX bam-1807 228 11 challenge challenge VERB bam-1807 228 12 the the DET bam-1807 228 13 survival survival NOUN bam-1807 228 14 itself itself PRON bam-1807 228 15 of of ADP bam-1807 228 16 the the DET bam-1807 228 17 fiber fiber NOUN bam-1807 228 18 ; ; PUNCT bam-1807 228 19 in in ADP bam-1807 228 20 fact fact NOUN bam-1807 228 21 , , PUNCT bam-1807 228 22 skeletal skeletal ADJ bam-1807 228 23 muscle muscle NOUN bam-1807 228 24 contains contain VERB bam-1807 228 25 calpains calpain NOUN bam-1807 228 26 , , PUNCT bam-1807 228 27 ca2 ca2 PROPN bam-1807 228 28 + + SYM bam-1807 228 29 -activated -activate VERB bam-1807 228 30 proteases protease NOUN bam-1807 228 31 that that PRON bam-1807 228 32 may may AUX bam-1807 228 33 initiate initiate VERB bam-1807 228 34 different different ADJ bam-1807 228 35 damage damage NOUN bam-1807 228 36 pathways pathway NOUN bam-1807 228 37 . . PUNCT bam-1807 229 1 the the DET bam-1807 229 2 mechanism mechanism NOUN bam-1807 229 3 of of ADP bam-1807 229 4 muscle muscle NOUN bam-1807 229 5 fatigue fatigue NOUN bam-1807 229 6 , , PUNCT bam-1807 229 7 i.e. i.e. X bam-1807 229 8 the the DET bam-1807 229 9 mechanism mechanism NOUN bam-1807 229 10 by by ADP bam-1807 229 11 which which PRON bam-1807 229 12 repeated repeat VERB bam-1807 229 13 strenuous strenuous ADJ bam-1807 229 14 contractions contraction NOUN bam-1807 229 15 lead lead VERB bam-1807 229 16 to to ADP bam-1807 229 17 long long ADV bam-1807 229 18 - - PUNCT bam-1807 229 19 lasting last VERB bam-1807 229 20 decrease decrease NOUN bam-1807 229 21 in in ADP bam-1807 229 22 force force NOUN bam-1807 229 23 production production NOUN bam-1807 229 24 , , PUNCT bam-1807 229 25 has have AUX bam-1807 229 26 been be AUX bam-1807 229 27 recently recently ADV bam-1807 229 28 reviewed review VERB bam-1807 229 29 [ [ X bam-1807 229 30 8 8 NUM bam-1807 229 31 ; ; PUNCT bam-1807 229 32 58 58 NUM bam-1807 229 33 ] ] PUNCT bam-1807 229 34 and and CCONJ bam-1807 229 35 seems seem VERB bam-1807 229 36 to to PART bam-1807 229 37 be be AUX bam-1807 229 38 related relate VERB bam-1807 229 39 to to ADP bam-1807 229 40 e e NOUN bam-1807 229 41 - - NOUN bam-1807 229 42 c c ADJ bam-1807 229 43 uncoupling uncoupling NOUN bam-1807 229 44 and and CCONJ bam-1807 229 45 acquired acquire VERB bam-1807 229 46 ca2 ca2 PROPN bam-1807 229 47 + + PROPN bam-1807 229 48 leakage leakage NOUN bam-1807 229 49 from from ADP bam-1807 229 50 ryr1 ryr1 NOUN bam-1807 229 51 channels channel NOUN bam-1807 229 52 . . PUNCT bam-1807 230 1 the the DET bam-1807 230 2 increase increase NOUN bam-1807 230 3 in in ADP bam-1807 230 4 [ [ X bam-1807 230 5 ca2+]cyt ca2+]cyt PROPN bam-1807 230 6 , , PUNCT bam-1807 230 7 released release VERB bam-1807 230 8 from from ADP bam-1807 230 9 the the DET bam-1807 230 10 leaky leaky PROPN bam-1807 230 11 sr sr PROPN bam-1807 230 12 membranes membrane NOUN bam-1807 230 13 , , PUNCT bam-1807 230 14 may may AUX bam-1807 230 15 locally locally ADV bam-1807 230 16 activate activate VERB bam-1807 230 17 µ-calpains µ-calpain NOUN bam-1807 230 18 , , PUNCT bam-1807 230 19 that that PRON bam-1807 230 20 may may AUX bam-1807 230 21 be be AUX bam-1807 230 22 directly directly ADV bam-1807 230 23 responsible responsible ADJ bam-1807 230 24 of of ADP bam-1807 230 25 the the DET bam-1807 230 26 e e PROPN bam-1807 230 27 - - NOUN bam-1807 230 28 c c ADJ bam-1807 230 29 uncoupling uncoupling NOUN bam-1807 230 30 and and CCONJ bam-1807 230 31 also also ADV bam-1807 230 32 of of ADP bam-1807 230 33 the the DET bam-1807 230 34 structural structural ADJ bam-1807 230 35 and and CCONJ bam-1807 230 36 morphological morphological ADJ bam-1807 230 37 damages damage NOUN bam-1807 230 38 of of ADP bam-1807 230 39 the the DET bam-1807 230 40 triad triad ADJ bam-1807 230 41 system system NOUN bam-1807 230 42 , , PUNCT bam-1807 230 43 that that PRON bam-1807 230 44 have have AUX bam-1807 230 45 been be AUX bam-1807 230 46 observed observe VERB bam-1807 230 47 as as ADP bam-1807 230 48 a a DET bam-1807 230 49 consequence consequence NOUN bam-1807 230 50 of of ADP bam-1807 230 51 eccentric eccentric ADJ bam-1807 230 52 exercise exercise NOUN bam-1807 230 53 [ [ X bam-1807 230 54 111 111 NUM bam-1807 230 55 ] ] PUNCT bam-1807 230 56 . . PUNCT bam-1807 231 1 moreover moreover ADV bam-1807 231 2 , , PUNCT bam-1807 231 3 increases increase NOUN bam-1807 231 4 in in ADP bam-1807 231 5 [ [ X bam-1807 231 6 ca2+]cyt ca2+]cyt PROPN bam-1807 231 7 may may AUX bam-1807 231 8 also also ADV bam-1807 231 9 impose impose VERB bam-1807 231 10 a a DET bam-1807 231 11 compensatory compensatory ADJ bam-1807 231 12 activity activity NOUN bam-1807 231 13 of of ADP bam-1807 231 14 serca1a serca1a NOUN bam-1807 231 15 atpase atpase PROPN bam-1807 231 16 , , PUNCT bam-1807 231 17 thus thus ADV bam-1807 231 18 contributing contribute VERB bam-1807 231 19 to to ADP bam-1807 231 20 atp atp NOUN bam-1807 231 21 depletion depletion NOUN bam-1807 231 22 in in ADP bam-1807 231 23 the the DET bam-1807 231 24 fatiguing fatigue VERB bam-1807 231 25 muscle muscle NOUN bam-1807 231 26 . . PUNCT bam-1807 232 1 in in ADP bam-1807 232 2 a a DET bam-1807 232 3 recent recent ADJ bam-1807 232 4 study study NOUN bam-1807 232 5 , , PUNCT bam-1807 232 6 duhamel duhamel VERB bam-1807 232 7 et et PROPN bam-1807 232 8 al al PROPN bam-1807 232 9 . . PUNCT bam-1807 233 1 [ [ X bam-1807 233 2 23 23 NUM bam-1807 233 3 ] ] PUNCT bam-1807 233 4 analyzed analyze VERB bam-1807 233 5 the the DET bam-1807 233 6 establishment establishment NOUN bam-1807 233 7 of of ADP bam-1807 233 8 adaptive adaptive ADJ bam-1807 233 9 mechanisms mechanism NOUN bam-1807 233 10 in in ADP bam-1807 233 11 the the DET bam-1807 233 12 muscle muscle NOUN bam-1807 233 13 ca2 ca2 PROPN bam-1807 233 14 + + PROPN bam-1807 233 15 -cycling -cycling ADJ bam-1807 233 16 properties property NOUN bam-1807 233 17 following follow VERB bam-1807 233 18 three three NUM bam-1807 233 19 days day NOUN bam-1807 233 20 of of ADP bam-1807 233 21 intense intense ADJ bam-1807 233 22 exercise exercise NOUN bam-1807 233 23 in in ADP bam-1807 233 24 humans human NOUN bam-1807 233 25 . . PUNCT bam-1807 234 1 exercise exercise NOUN bam-1807 234 2 resulted result VERB bam-1807 234 3 into into ADP bam-1807 234 4 an an DET bam-1807 234 5 increase increase NOUN bam-1807 234 6 in in ADP bam-1807 234 7 serca1a serca1a NOUN bam-1807 234 8 but but CCONJ bam-1807 234 9 not not PART bam-1807 234 10 serca2a serca2a PROPN bam-1807 234 11 , , PUNCT bam-1807 234 12 meaning mean VERB bam-1807 234 13 that that SCONJ bam-1807 234 14 adapting adapt VERB bam-1807 234 15 mechanisms mechanism NOUN bam-1807 234 16 protect protect VERB bam-1807 234 17 maximal maximal ADJ bam-1807 234 18 ca2 ca2 PROPN bam-1807 234 19 + + CCONJ bam-1807 234 20 -atpase -atpase NOUN bam-1807 234 21 activity activity NOUN bam-1807 234 22 but but CCONJ bam-1807 234 23 not not PART bam-1807 234 24 ca2 ca2 PROPN bam-1807 234 25 + + X bam-1807 234 26 uptake uptake ADJ bam-1807 234 27 and and CCONJ bam-1807 234 28 ca2 ca2 PROPN bam-1807 234 29 + + NOUN bam-1807 234 30 release release NOUN bam-1807 234 31 . . PUNCT bam-1807 235 1 although although SCONJ bam-1807 235 2 the the DET bam-1807 235 3 excitation excitation NOUN bam-1807 235 4 - - PUNCT bam-1807 235 5 contraction contraction NOUN bam-1807 235 6 coupling coupling NOUN bam-1807 235 7 apparatus apparatus NOUN bam-1807 235 8 comprises comprise VERB bam-1807 235 9 dozens dozen NOUN bam-1807 235 10 of of ADP bam-1807 235 11 ca2 ca2 PROPN bam-1807 235 12 + + ADJ bam-1807 235 13 -handling -handling ADJ bam-1807 235 14 proteins protein NOUN bam-1807 235 15 , , PUNCT bam-1807 235 16 located locate VERB bam-1807 235 17 in in ADP bam-1807 235 18 the the DET bam-1807 235 19 sr sr PROPN bam-1807 235 20 lumen luman NOUN bam-1807 235 21 , , PUNCT bam-1807 235 22 in in ADP bam-1807 235 23 the the DET bam-1807 235 24 sr sr PROPN bam-1807 235 25 and and CCONJ bam-1807 235 26 in in ADP bam-1807 235 27 plasma plasma NOUN bam-1807 235 28 membranes membrane NOUN bam-1807 235 29 , , PUNCT bam-1807 235 30 as as ADV bam-1807 235 31 well well ADV bam-1807 235 32 as as ADP bam-1807 235 33 in in ADP bam-1807 235 34 the the DET bam-1807 235 35 cytosol cytosol NOUN bam-1807 235 36 , , PUNCT bam-1807 235 37 to to ADP bam-1807 235 38 our our PRON bam-1807 235 39 knowledge knowledge NOUN bam-1807 235 40 other other ADJ bam-1807 235 41 exercise exercise NOUN bam-1807 235 42 - - PUNCT bam-1807 235 43 induced induce VERB bam-1807 235 44 adaptive adaptive ADJ bam-1807 235 45 mechanisms mechanism NOUN bam-1807 235 46 have have AUX bam-1807 235 47 not not PART bam-1807 235 48 been be AUX bam-1807 235 49 investigated investigate VERB bam-1807 235 50 . . PUNCT bam-1807 236 1 development development NOUN bam-1807 236 2 of of ADP bam-1807 236 3 strength strength NOUN bam-1807 236 4 is be AUX bam-1807 236 5 an an DET bam-1807 236 6 obvious obvious ADJ bam-1807 236 7 output output NOUN bam-1807 236 8 of of ADP bam-1807 236 9 exercise exercise NOUN bam-1807 236 10 training training NOUN bam-1807 236 11 , , PUNCT bam-1807 236 12 which which PRON bam-1807 236 13 particularly particularly ADV bam-1807 236 14 concerns concern VERB bam-1807 236 15 sport sport NOUN bam-1807 236 16 professionals professional NOUN bam-1807 236 17 . . PUNCT bam-1807 237 1 most most ADJ bam-1807 237 2 of of ADP bam-1807 237 3 the the DET bam-1807 237 4 above above ADV bam-1807 237 5 mentioned mention VERB bam-1807 237 6 mechanisms mechanism NOUN bam-1807 237 7 lead lead VERB bam-1807 237 8 to to ADP bam-1807 237 9 training training NOUN bam-1807 237 10 - - PUNCT bam-1807 237 11 associated associate VERB bam-1807 237 12 development development NOUN bam-1807 237 13 of of ADP bam-1807 237 14 strength strength NOUN bam-1807 237 15 . . PUNCT bam-1807 238 1 additional additional ADJ bam-1807 238 2 mechanisms mechanism NOUN bam-1807 238 3 have have AUX bam-1807 238 4 been be AUX bam-1807 238 5 recently recently ADV bam-1807 238 6 suggested suggest VERB bam-1807 238 7 to to PART bam-1807 238 8 contribute contribute VERB bam-1807 238 9 to to ADP bam-1807 238 10 the the DET bam-1807 238 11 building building NOUN bam-1807 238 12 up up ADP bam-1807 238 13 of of ADP bam-1807 238 14 strength strength NOUN bam-1807 238 15 , , PUNCT bam-1807 238 16 such such ADJ bam-1807 238 17 as as ADP bam-1807 238 18 training training NOUN bam-1807 238 19 - - PUNCT bam-1807 238 20 induced induce VERB bam-1807 238 21 phosphorylation phosphorylation NOUN bam-1807 238 22 of of ADP bam-1807 238 23 myosin myosin PROPN bam-1807 238 24 regulatory regulatory ADJ bam-1807 238 25 light light ADJ bam-1807 238 26 chains chain NOUN bam-1807 238 27 , , PUNCT bam-1807 238 28 increased increase VERB bam-1807 238 29 recruitment recruitment NOUN bam-1807 238 30 of of ADP bam-1807 238 31 higher high ADJ bam-1807 238 32 order order NOUN bam-1807 238 33 motor motor NOUN bam-1807 238 34 units unit NOUN bam-1807 238 35 , , PUNCT bam-1807 238 36 a a DET bam-1807 238 37 possible possible ADJ bam-1807 238 38 change change NOUN bam-1807 238 39 in in ADP bam-1807 238 40 pennation pennation NOUN bam-1807 238 41 angle angle NOUN bam-1807 238 42 ( ( PUNCT bam-1807 238 43 i.e. i.e. X bam-1807 238 44 the the DET bam-1807 238 45 angle angle NOUN bam-1807 238 46 between between ADP bam-1807 238 47 the the DET bam-1807 238 48 longitudinal longitudinal ADJ bam-1807 238 49 axes axis NOUN bam-1807 238 50 of of ADP bam-1807 238 51 the the DET bam-1807 238 52 whole whole ADJ bam-1807 238 53 muscle muscle NOUN bam-1807 238 54 and and CCONJ bam-1807 238 55 its its PRON bam-1807 238 56 fibers fiber NOUN bam-1807 238 57 for for ADP bam-1807 238 58 a a DET bam-1807 238 59 pennate pennate ADJ bam-1807 238 60 - - PUNCT bam-1807 238 61 fiber fiber NOUN bam-1807 238 62 muscle muscle NOUN bam-1807 238 63 ) ) PUNCT bam-1807 239 1 [ [ X bam-1807 239 2 113 113 NUM bam-1807 239 3 ] ] PUNCT bam-1807 239 4 , , PUNCT bam-1807 239 5 changes change NOUN bam-1807 239 6 in in ADP bam-1807 239 7 neuromuscular neuromuscular ADJ bam-1807 239 8 control control NOUN bam-1807 239 9 [ [ X bam-1807 239 10 12 12 NUM bam-1807 239 11 ] ] PUNCT bam-1807 239 12 and and CCONJ bam-1807 239 13 in in ADP bam-1807 239 14 endothelial endothelial ADJ bam-1807 239 15 function function NOUN bam-1807 239 16 [ [ X bam-1807 239 17 21 21 NUM bam-1807 239 18 ] ] PUNCT bam-1807 239 19 . . PUNCT bam-1807 240 1 7 7 X bam-1807 240 2 . . X bam-1807 240 3 exercise exercise NOUN bam-1807 240 4 and and CCONJ bam-1807 240 5 generation generation NOUN bam-1807 240 6 of of ADP bam-1807 240 7 reactive reactive ADJ bam-1807 240 8 oxygen oxygen NOUN bam-1807 240 9 and and CCONJ bam-1807 240 10 nitrogen nitrogen NOUN bam-1807 240 11 species specie NOUN bam-1807 240 12 ( ( PUNCT bam-1807 240 13 rons ron NOUN bam-1807 240 14 ) ) PUNCT bam-1807 240 15 during during ADP bam-1807 240 16 intense intense ADJ bam-1807 240 17 activity activity NOUN bam-1807 240 18 , , PUNCT bam-1807 240 19 the the DET bam-1807 240 20 high high ADJ bam-1807 240 21 rate rate NOUN bam-1807 240 22 of of ADP bam-1807 240 23 o2 o2 ADJ bam-1807 240 24 consumption consumption NOUN bam-1807 240 25 ( ( PUNCT bam-1807 240 26 vo2 vo2 NOUN bam-1807 240 27 ) ) PUNCT bam-1807 240 28 in in ADP bam-1807 240 29 skeletal skeletal ADJ bam-1807 240 30 muscles muscle NOUN bam-1807 240 31 can can AUX bam-1807 240 32 cause cause VERB bam-1807 240 33 incomplete incomplete ADJ bam-1807 240 34 oxygen oxygen NOUN bam-1807 240 35 reduction reduction NOUN bam-1807 240 36 and and CCONJ bam-1807 240 37 electron electron NOUN bam-1807 240 38 leakage leakage NOUN bam-1807 240 39 from from ADP bam-1807 240 40 the the DET bam-1807 240 41 electron electron NOUN bam-1807 240 42 transfer transfer NOUN bam-1807 240 43 chain chain NOUN bam-1807 240 44 , , PUNCT bam-1807 240 45 leading lead VERB bam-1807 240 46 to to ADP bam-1807 240 47 the the DET bam-1807 240 48 generation generation NOUN bam-1807 240 49 of of ADP bam-1807 240 50 superoxide(o.2 superoxide(o.2 PROPN bam-1807 240 51 ) ) PUNCT bam-1807 240 52 , , PUNCT bam-1807 240 53 hydrogen hydrogen NOUN bam-1807 240 54 peroxide peroxide NOUN bam-1807 240 55 ( ( PUNCT bam-1807 240 56 h2o2 h2o2 NOUN bam-1807 240 57 ) ) PUNCT bam-1807 240 58 and and CCONJ bam-1807 240 59 hydroxyl hydroxyl PROPN bam-1807 240 60 radical radical PROPN bam-1807 240 61 ( ( PUNCT bam-1807 240 62 .oh .oh PROPN bam-1807 240 63 ) ) PUNCT bam-1807 240 64 . . PUNCT bam-1807 241 1 together together ADV bam-1807 241 2 with with ADP bam-1807 241 3 nitric nitric ADJ bam-1807 241 4 oxide oxide NOUN bam-1807 241 5 and and CCONJ bam-1807 241 6 its its PRON bam-1807 241 7 reaction reaction NOUN bam-1807 241 8 products product NOUN bam-1807 241 9 , , PUNCT bam-1807 241 10 which which PRON bam-1807 241 11 are be AUX bam-1807 241 12 generated generate VERB bam-1807 241 13 as as ADV bam-1807 241 14 well well ADV bam-1807 241 15 in in ADP bam-1807 241 16 the the DET bam-1807 241 17 active active ADJ bam-1807 241 18 muscle muscle NOUN bam-1807 241 19 , , PUNCT bam-1807 241 20 these these DET bam-1807 241 21 reactive reactive ADJ bam-1807 241 22 nitrogen nitrogen NOUN bam-1807 241 23 and and CCONJ bam-1807 241 24 oxygen oxygen NOUN bam-1807 241 25 species specie NOUN bam-1807 241 26 , , PUNCT bam-1807 241 27 collectively collectively ADV bam-1807 241 28 known know VERB bam-1807 241 29 as as ADP bam-1807 241 30 rons ron NOUN bam-1807 241 31 , , PUNCT bam-1807 241 32 may may AUX bam-1807 241 33 cause cause VERB bam-1807 241 34 the the DET bam-1807 241 35 establishment establishment NOUN bam-1807 241 36 of of ADP bam-1807 241 37 a a DET bam-1807 241 38 condition condition NOUN bam-1807 241 39 known know VERB bam-1807 241 40 as as ADP bam-1807 241 41 “ " PUNCT bam-1807 241 42 oxidative oxidative ADJ bam-1807 241 43 stress stress NOUN bam-1807 241 44 ” " PUNCT bam-1807 241 45 . . PUNCT bam-1807 242 1 according accord VERB bam-1807 242 2 to to ADP bam-1807 242 3 the the DET bam-1807 242 4 definition definition NOUN bam-1807 242 5 given give VERB bam-1807 242 6 by by ADP bam-1807 242 7 sies sie NOUN bam-1807 242 8 [ [ X bam-1807 242 9 105 105 NUM bam-1807 242 10 ] ] PUNCT bam-1807 242 11 , , PUNCT bam-1807 242 12 oxidative oxidative ADJ bam-1807 242 13 stress stress NOUN bam-1807 242 14 is be AUX bam-1807 242 15 the the DET bam-1807 242 16 “ " PUNCT bam-1807 242 17 imbalance imbalance NOUN bam-1807 242 18 between between ADP bam-1807 242 19 oxidants oxidant NOUN bam-1807 242 20 and and CCONJ bam-1807 242 21 antioxidants antioxidant NOUN bam-1807 242 22 in in ADP bam-1807 242 23 favor favor NOUN bam-1807 242 24 of of ADP bam-1807 242 25 the the DET bam-1807 242 26 oxidants oxidant NOUN bam-1807 242 27 , , PUNCT bam-1807 242 28 potentially potentially ADV bam-1807 242 29 leading lead VERB bam-1807 242 30 to to ADP bam-1807 242 31 damage damage NOUN bam-1807 242 32 ” " PUNCT bam-1807 242 33 . . PUNCT bam-1807 243 1 the the DET bam-1807 243 2 first first ADJ bam-1807 243 3 evidence evidence NOUN bam-1807 243 4 that that PRON bam-1807 243 5 exercise exercise VERB bam-1807 243 6 induced induce VERB bam-1807 243 7 increases increase NOUN bam-1807 243 8 in in ADP bam-1807 243 9 rons ron NOUN bam-1807 243 10 came come VERB bam-1807 243 11 from from ADP bam-1807 243 12 electron electron NOUN bam-1807 243 13 spin spin NOUN bam-1807 243 14 resonance resonance NOUN bam-1807 243 15 data datum NOUN bam-1807 243 16 [ [ X bam-1807 243 17 20 20 NUM bam-1807 243 18 , , PUNCT bam-1807 243 19 48 48 NUM bam-1807 243 20 ] ] PUNCT bam-1807 243 21 . . PUNCT bam-1807 244 1 further further PROPN bam-1807 244 2 studies study NOUN bam-1807 244 3 demonstrated demonstrate VERB bam-1807 244 4 that that SCONJ bam-1807 244 5 active active ADJ bam-1807 244 6 skeletal skeletal ADJ bam-1807 244 7 muscles muscle NOUN bam-1807 244 8 released release VERB bam-1807 244 9 nitric nitric ADJ bam-1807 244 10 oxide oxide NOUN bam-1807 244 11 [ [ X bam-1807 244 12 7 7 NUM bam-1807 244 13 ] ] PUNCT bam-1807 244 14 , , PUNCT bam-1807 244 15 hydroxyl hydroxyl NOUN bam-1807 244 16 radicals radical NOUN bam-1807 244 17 [ [ X bam-1807 244 18 84 84 NUM bam-1807 244 19 ] ] PUNCT bam-1807 244 20 , , PUNCT bam-1807 244 21 superoxide superoxide NOUN bam-1807 244 22 anions anion NOUN bam-1807 244 23 [ [ X bam-1807 244 24 70 70 NUM bam-1807 244 25 ] ] PUNCT bam-1807 244 26 and and CCONJ bam-1807 244 27 hydrogen hydrogen NOUN bam-1807 244 28 peroxide peroxide NOUN bam-1807 244 29 [ [ X bam-1807 244 30 71 71 NUM bam-1807 244 31 ] ] PUNCT bam-1807 244 32 , , PUNCT bam-1807 244 33 but but CCONJ bam-1807 244 34 only only ADV bam-1807 244 35 recently recently ADV bam-1807 244 36 it it PRON bam-1807 244 37 was be AUX bam-1807 244 38 incontrovertibly incontrovertibly ADV bam-1807 244 39 demonstrated demonstrate VERB bam-1807 244 40 that that SCONJ bam-1807 244 41 mitochondria mitochondria PROPN bam-1807 244 42 are be AUX bam-1807 244 43 the the DET bam-1807 244 44 major major ADJ bam-1807 244 45 biological biological ADJ bam-1807 244 46 source source NOUN bam-1807 244 47 of of ADP bam-1807 244 48 ros ros PROPN bam-1807 244 49 production production NOUN bam-1807 244 50 during during ADP bam-1807 244 51 physical physical ADJ bam-1807 244 52 exercise exercise NOUN bam-1807 245 1 [ [ X bam-1807 245 2 93 93 NUM bam-1807 245 3 ] ] PUNCT bam-1807 245 4 . . PUNCT bam-1807 246 1 in in ADP bam-1807 246 2 fact fact NOUN bam-1807 246 3 , , PUNCT bam-1807 246 4 there there PRON bam-1807 246 5 are be VERB bam-1807 246 6 a a DET bam-1807 246 7 number number NOUN bam-1807 246 8 of of ADP bam-1807 246 9 possible possible ADJ bam-1807 246 10 intracellular intracellular ADJ bam-1807 246 11 sources source NOUN bam-1807 246 12 for for ADP bam-1807 246 13 ros ros PROPN bam-1807 246 14 beside beside ADP bam-1807 246 15 mitochondria mitochondria PROPN bam-1807 246 16 , , PUNCT bam-1807 246 17 including include VERB bam-1807 246 18 cytochrome cytochrome NOUN bam-1807 246 19 p450 p450 NUM bam-1807 246 20 , , PUNCT bam-1807 246 21 myeloperoxidase myeloperoxidase NOUN bam-1807 246 22 , , PUNCT bam-1807 246 23 xanthine xanthine NOUN bam-1807 246 24 oxidase oxidase PROPN bam-1807 246 25 , , PUNCT bam-1807 246 26 nadh nadh NOUN bam-1807 246 27 oxidase oxidase NOUN bam-1807 246 28 and and CCONJ bam-1807 246 29 peroxisomal peroxisomal ADJ bam-1807 246 30 oxidative oxidative ADJ bam-1807 246 31 enzymes enzyme NOUN bam-1807 246 32 , , PUNCT bam-1807 246 33 all all PRON bam-1807 246 34 of of ADP bam-1807 246 35 which which PRON bam-1807 246 36 may may AUX bam-1807 246 37 be be AUX bam-1807 246 38 substantially substantially ADV bam-1807 246 39 increased increase VERB bam-1807 246 40 upon upon SCONJ bam-1807 246 41 exercise exercise NOUN bam-1807 246 42 . . PUNCT bam-1807 247 1 high high ADJ bam-1807 247 2 levels level NOUN bam-1807 247 3 of of ADP bam-1807 247 4 ros ros PROPN bam-1807 247 5 generation generation NOUN bam-1807 247 6 have have AUX bam-1807 247 7 been be AUX bam-1807 247 8 associated associate VERB bam-1807 247 9 to to ADP bam-1807 247 10 cellular cellular ADJ bam-1807 247 11 dysfunction dysfunction NOUN bam-1807 247 12 and and CCONJ bam-1807 247 13 dna dna NOUN bam-1807 247 14 , , PUNCT bam-1807 247 15 protein protein NOUN bam-1807 247 16 and and CCONJ bam-1807 247 17 lipid lipid ADJ bam-1807 247 18 damage damage NOUN bam-1807 248 1 [ [ X bam-1807 248 2 75 75 NUM bam-1807 248 3 ] ] PUNCT bam-1807 248 4 ; ; PUNCT bam-1807 248 5 in in ADP bam-1807 248 6 muscle muscle NOUN bam-1807 248 7 cells cell NOUN bam-1807 248 8 , , PUNCT bam-1807 248 9 they they PRON bam-1807 248 10 have have AUX bam-1807 248 11 been be AUX bam-1807 248 12 suggested suggest VERB bam-1807 248 13 to to PART bam-1807 248 14 mediate mediate VERB bam-1807 248 15 muscle muscle NOUN bam-1807 248 16 fatigue fatigue NOUN bam-1807 248 17 [ [ X bam-1807 248 18 85 85 NUM bam-1807 248 19 , , PUNCT bam-1807 248 20 88 88 NUM bam-1807 248 21 ] ] PUNCT bam-1807 248 22 . . PUNCT bam-1807 249 1 however however ADV bam-1807 249 2 , , PUNCT bam-1807 249 3 exerciseassociated exerciseassociate VERB bam-1807 249 4 ros ros PROPN bam-1807 249 5 production production NOUN bam-1807 249 6 in in ADP bam-1807 249 7 the the DET bam-1807 249 8 skeletal skeletal ADJ bam-1807 249 9 muscles muscle NOUN bam-1807 249 10 may may AUX bam-1807 249 11 be be AUX bam-1807 249 12 quantitatively quantitatively ADV bam-1807 249 13 limited limit VERB bam-1807 249 14 or or CCONJ bam-1807 249 15 , , PUNCT bam-1807 249 16 rather rather ADV bam-1807 249 17 , , PUNCT bam-1807 249 18 counteracted counteract VERB bam-1807 249 19 by by ADP bam-1807 249 20 anti anti NOUN bam-1807 249 21 - - NOUN bam-1807 249 22 oxidants oxidant NOUN bam-1807 249 23 , , PUNCT bam-1807 249 24 so so SCONJ bam-1807 249 25 that that SCONJ bam-1807 249 26 an an DET bam-1807 249 27 “ " PUNCT bam-1807 249 28 unbalance unbalance NOUN bam-1807 249 29 between between ADP bam-1807 249 30 oxidants oxidant NOUN bam-1807 249 31 and and CCONJ bam-1807 249 32 antioxidants antioxidant NOUN bam-1807 249 33 in in ADP bam-1807 249 34 favor favor NOUN bam-1807 249 35 of of ADP bam-1807 249 36 the the DET bam-1807 249 37 oxidants oxidant NOUN bam-1807 249 38 ” " PUNCT bam-1807 249 39 , , PUNCT bam-1807 249 40 that that PRON bam-1807 249 41 is be AUX bam-1807 249 42 oxidative oxidative ADJ bam-1807 249 43 stress stress NOUN bam-1807 249 44 , , PUNCT bam-1807 249 45 does do AUX bam-1807 249 46 not not PART bam-1807 249 47 necessarily necessarily ADV bam-1807 249 48 become become AUX bam-1807 249 49 established establish VERB bam-1807 249 50 . . PUNCT bam-1807 250 1 in in ADP bam-1807 250 2 fact fact NOUN bam-1807 250 3 , , PUNCT bam-1807 250 4 it it PRON bam-1807 250 5 was be AUX bam-1807 250 6 also also ADV bam-1807 250 7 shown show VERB bam-1807 250 8 that that SCONJ bam-1807 250 9 skeletal skeletal ADJ bam-1807 250 10 muscle muscle NOUN bam-1807 250 11 adapted adapt VERB bam-1807 250 12 to to ADP bam-1807 250 13 the the DET bam-1807 250 14 exercise exercise NOUN bam-1807 250 15 - - PUNCT bam-1807 250 16 induced induce VERB bam-1807 250 17 oxidative oxidative ADJ bam-1807 250 18 environment environment NOUN bam-1807 250 19 by by ADP bam-1807 250 20 upregulating upregulate VERB bam-1807 250 21 a a DET bam-1807 250 22 number number NOUN bam-1807 250 23 of of ADP bam-1807 250 24 antioxidant antioxidant ADJ bam-1807 250 25 enzymes enzyme NOUN bam-1807 250 26 and and CCONJ bam-1807 250 27 molecular molecular ADJ bam-1807 250 28 chaperones chaperone NOUN bam-1807 251 1 [ [ X bam-1807 251 2 70 70 NUM bam-1807 251 3 , , PUNCT bam-1807 251 4 71 71 NUM bam-1807 251 5 ] ] PUNCT bam-1807 251 6 , , PUNCT bam-1807 251 7 that that PRON bam-1807 251 8 allowed allow VERB bam-1807 251 9 it it PRON bam-1807 251 10 to to PART bam-1807 251 11 be be AUX bam-1807 251 12 protected protect VERB bam-1807 251 13 against against ADP bam-1807 251 14 a a DET bam-1807 251 15 damaging damaging ADJ bam-1807 251 16 contraction contraction NOUN bam-1807 251 17 protocol protocol NOUN bam-1807 251 18 in in ADP bam-1807 251 19 vitro vitro X bam-1807 251 20 [ [ X bam-1807 251 21 72 72 NUM bam-1807 251 22 ] ] PUNCT bam-1807 251 23 . . PUNCT bam-1807 252 1 in in ADP bam-1807 252 2 particular particular ADJ bam-1807 252 3 , , PUNCT bam-1807 252 4 by by ADP bam-1807 252 5 using use VERB bam-1807 252 6 a a DET bam-1807 252 7 protocol protocol NOUN bam-1807 252 8 of of ADP bam-1807 252 9 muscle muscle NOUN bam-1807 252 10 stimulation stimulation NOUN bam-1807 252 11 in in ADP bam-1807 252 12 vivo vivo NOUN bam-1807 252 13 , , PUNCT bam-1807 252 14 a a DET bam-1807 252 15 rapid rapid ADJ bam-1807 252 16 transient transient ADJ bam-1807 252 17 reduction reduction NOUN bam-1807 252 18 in in ADP bam-1807 252 19 muscle muscle NOUN bam-1807 252 20 protein protein NOUN bam-1807 252 21 thiol thiol PROPN bam-1807 252 22 content content NOUN bam-1807 252 23 , , PUNCT bam-1807 252 24 followed follow VERB bam-1807 252 25 by by ADP bam-1807 252 26 increases increase NOUN bam-1807 252 27 in in ADP bam-1807 252 28 the the DET bam-1807 252 29 activities activity NOUN bam-1807 252 30 of of ADP bam-1807 252 31 superoxide superoxide NOUN bam-1807 252 32 dismutase dismutase NOUN bam-1807 252 33 and and CCONJ bam-1807 252 34 catalase catalase NOUN bam-1807 252 35 and and CCONJ bam-1807 252 36 in in ADP bam-1807 252 37 the the DET bam-1807 252 38 content content NOUN bam-1807 252 39 of of ADP bam-1807 252 40 hsp60 hsp60 NOUN bam-1807 252 41 , , PUNCT bam-1807 252 42 hsp70 hsp70 NOUN bam-1807 252 43 and and CCONJ bam-1807 252 44 haemoxygenase haemoxygenase PROPN bam-1807 252 45 proteins protein NOUN bam-1807 252 46 in in ADP bam-1807 252 47 both both CCONJ bam-1807 252 48 edl edl PROPN bam-1807 252 49 and and CCONJ bam-1807 252 50 soleus soleus NOUN bam-1807 252 51 was be AUX bam-1807 252 52 found find VERB bam-1807 252 53 [ [ X bam-1807 252 54 70 70 NUM bam-1807 252 55 - - SYM bam-1807 252 56 72 72 NUM bam-1807 252 57 ] ] PUNCT bam-1807 252 58 . . PUNCT bam-1807 253 1 the the DET bam-1807 253 2 regulation regulation NOUN bam-1807 253 3 of of ADP bam-1807 253 4 the the DET bam-1807 253 5 exercise exercise NOUN bam-1807 253 6 - - PUNCT bam-1807 253 7 induced induce VERB bam-1807 253 8 stress stress NOUN bam-1807 253 9 response response NOUN bam-1807 253 10 of of ADP bam-1807 253 11 skeletal skeletal ADJ bam-1807 253 12 muscle muscle NOUN bam-1807 253 13 has have AUX bam-1807 253 14 been be AUX bam-1807 253 15 recently recently ADV bam-1807 253 16 reviewed review VERB bam-1807 253 17 [ [ X bam-1807 253 18 76 76 NUM bam-1807 253 19 ] ] PUNCT bam-1807 253 20 on on ADP bam-1807 253 21 the the DET bam-1807 253 22 other other ADJ bam-1807 253 23 hand hand NOUN bam-1807 253 24 , , PUNCT bam-1807 253 25 a a DET bam-1807 253 26 low low ADJ bam-1807 253 27 level level NOUN bam-1807 253 28 of of ADP bam-1807 253 29 ros ros PROPN bam-1807 253 30 should should AUX bam-1807 253 31 be be AUX bam-1807 253 32 regarded regard VERB bam-1807 253 33 as as ADP bam-1807 253 34 a a DET bam-1807 253 35 means means NOUN bam-1807 253 36 of of ADP bam-1807 253 37 regulating regulate VERB bam-1807 253 38 signaling signal VERB bam-1807 253 39 cascades cascade NOUN bam-1807 253 40 , , PUNCT bam-1807 253 41 metabolic metabolic NOUN bam-1807 253 42 and and CCONJ bam-1807 253 43 adaptive adaptive ADJ bam-1807 253 44 responses response NOUN bam-1807 253 45 , , PUNCT bam-1807 253 46 and and CCONJ bam-1807 253 47 the the DET bam-1807 253 48 induction induction NOUN bam-1807 253 49 of of ADP bam-1807 253 50 the the DET bam-1807 253 51 exercised exercise VERB bam-1807 253 52 skeletal skeletal ADJ bam-1807 253 53 muscle muscle NOUN bam-1807 253 54 european european PROPN bam-1807 253 55 journal journal PROPN bam-1807 253 56 translational translational ADJ bam-1807 253 57 myology myology NOUN bam-1807 253 58 myology myology NOUN bam-1807 253 59 reviews review VERB bam-1807 253 60 20 20 NUM bam-1807 253 61 ( ( PUNCT bam-1807 253 62 3 3 NUM bam-1807 253 63 ): ): PUNCT bam-1807 253 64 105 105 NUM bam-1807 253 65 - - SYM bam-1807 253 66 120 120 NUM bam-1807 253 67 , , PUNCT bam-1807 253 68 2010 2010 NUM bam-1807 253 69 113 113 NUM bam-1807 253 70 endogenous endogenous ADJ bam-1807 253 71 defense defense NOUN bam-1807 253 72 systems system NOUN bam-1807 253 73 , , PUNCT bam-1807 253 74 rather rather ADV bam-1807 253 75 than than ADP bam-1807 253 76 a a DET bam-1807 253 77 dangerous dangerous ADJ bam-1807 253 78 challenge challenge NOUN bam-1807 253 79 leading lead VERB bam-1807 253 80 to to ADP bam-1807 253 81 cell cell NOUN bam-1807 253 82 damage damage NOUN bam-1807 253 83 or or CCONJ bam-1807 253 84 even even ADV bam-1807 253 85 cell cell NOUN bam-1807 253 86 death death NOUN bam-1807 253 87 ( ( PUNCT bam-1807 253 88 reviewed review VERB bam-1807 253 89 by by ADP bam-1807 253 90 freyssenet freyssenet NOUN bam-1807 253 91 [ [ X bam-1807 253 92 29 29 NUM bam-1807 253 93 ] ] PUNCT bam-1807 253 94 and and CCONJ bam-1807 253 95 by by ADP bam-1807 253 96 powers power NOUN bam-1807 253 97 and and CCONJ bam-1807 253 98 jackson jackson PROPN bam-1807 254 1 [ [ X bam-1807 254 2 85 85 NUM bam-1807 254 3 ] ] NUM bam-1807 254 4 ) ) PUNCT bam-1807 254 5 . . PUNCT bam-1807 255 1 increased increase VERB bam-1807 255 2 ros ros PROPN bam-1807 255 3 production production NOUN bam-1807 255 4 is be AUX bam-1807 255 5 associated associate VERB bam-1807 255 6 with with ADP bam-1807 255 7 mitochondrial mitochondrial ADJ bam-1807 255 8 network network NOUN bam-1807 255 9 elongation elongation NOUN bam-1807 255 10 and and CCONJ bam-1807 255 11 branching branch VERB bam-1807 255 12 complexity complexity NOUN bam-1807 255 13 [ [ X bam-1807 255 14 54 54 NUM bam-1807 255 15 ] ] PUNCT bam-1807 255 16 . . PUNCT bam-1807 256 1 downstream downstream ADJ bam-1807 256 2 effectors effector NOUN bam-1807 256 3 of of ADP bam-1807 256 4 ros ros PROPN bam-1807 256 5 are be AUX bam-1807 256 6 a a DET bam-1807 256 7 number number NOUN bam-1807 256 8 of of ADP bam-1807 256 9 key key ADJ bam-1807 256 10 transcription transcription NOUN bam-1807 256 11 factors factor NOUN bam-1807 256 12 , , PUNCT bam-1807 256 13 such such ADJ bam-1807 256 14 as as ADP bam-1807 256 15 nfκb nfκb NOUN bam-1807 256 16 , , PUNCT bam-1807 256 17 ap1 ap1 PROPN bam-1807 256 18 , , PUNCT bam-1807 256 19 hsf hsf NOUN bam-1807 256 20 , , PUNCT bam-1807 256 21 egr-1 egr-1 NUM bam-1807 256 22 , , PUNCT bam-1807 256 23 p53 p53 NOUN bam-1807 256 24 . . PUNCT bam-1807 257 1 recently recently ADV bam-1807 257 2 , , PUNCT bam-1807 257 3 it it PRON bam-1807 257 4 has have AUX bam-1807 257 5 been be AUX bam-1807 257 6 demonstrated demonstrate VERB bam-1807 257 7 that that SCONJ bam-1807 257 8 ros ros PROPN bam-1807 257 9 can can AUX bam-1807 257 10 induce induce VERB bam-1807 257 11 an an DET bam-1807 257 12 increase increase NOUN bam-1807 257 13 in in ADP bam-1807 257 14 pgc1 pgc1 NOUN bam-1807 257 15 - - PUNCT bam-1807 257 16 α α NOUN bam-1807 257 17 transcription transcription NOUN bam-1807 257 18 via via ADP bam-1807 257 19 both both PRON bam-1807 257 20 amp amp PROPN bam-1807 257 21 kinase kinase PROPN bam-1807 257 22 - - PUNCT bam-1807 257 23 dependent dependent ADJ bam-1807 257 24 and and CCONJ bam-1807 257 25 independent independent ADJ bam-1807 257 26 pathways pathway NOUN bam-1807 258 1 [ [ X bam-1807 258 2 47 47 NUM bam-1807 258 3 ] ] PUNCT bam-1807 258 4 . . PUNCT bam-1807 259 1 the the DET bam-1807 259 2 increase increase NOUN bam-1807 259 3 in in ADP bam-1807 259 4 pgc1 pgc1 PROPN bam-1807 259 5 - - PUNCT bam-1807 259 6 α α PROPN bam-1807 259 7 also also ADV bam-1807 259 8 causes cause VERB bam-1807 259 9 an an DET bam-1807 259 10 increase increase NOUN bam-1807 259 11 in in ADP bam-1807 259 12 nrf-1 nrf-1 NUM bam-1807 259 13 and and CCONJ bam-1807 259 14 tfam tfam NOUN bam-1807 259 15 levels level NOUN bam-1807 259 16 [ [ X bam-1807 259 17 51 51 NUM bam-1807 259 18 ] ] PUNCT bam-1807 259 19 . . PUNCT bam-1807 260 1 this this PRON bam-1807 260 2 directly directly ADV bam-1807 260 3 links link VERB bam-1807 260 4 ros ros PROPN bam-1807 260 5 production production NOUN bam-1807 260 6 to to ADP bam-1807 260 7 mitochondrial mitochondrial ADJ bam-1807 260 8 biogenesis biogenesis NOUN bam-1807 260 9 , , PUNCT bam-1807 260 10 that that ADV bam-1807 260 11 is is ADV bam-1807 260 12 , , PUNCT bam-1807 260 13 links link VERB bam-1807 260 14 the the DET bam-1807 260 15 exerciseinduced exerciseinduce VERB bam-1807 260 16 production production NOUN bam-1807 260 17 of of ADP bam-1807 260 18 ros ros PROPN bam-1807 260 19 in in ADP bam-1807 260 20 muscle muscle NOUN bam-1807 260 21 cells cell NOUN bam-1807 260 22 to to ADP bam-1807 260 23 the the DET bam-1807 260 24 cell cell NOUN bam-1807 260 25 's 's PART bam-1807 260 26 shift shift NOUN bam-1807 260 27 towards towards ADP bam-1807 260 28 a a DET bam-1807 260 29 more more ADV bam-1807 260 30 oxidative oxidative ADJ bam-1807 260 31 metabolism metabolism NOUN bam-1807 260 32 . . PUNCT bam-1807 261 1 nfκb nfκb NOUN bam-1807 261 2 and and CCONJ bam-1807 261 3 ap-1 ap-1 NOUN bam-1807 261 4 are be AUX bam-1807 261 5 both both PRON bam-1807 261 6 thought think VERB bam-1807 261 7 to to PART bam-1807 261 8 be be AUX bam-1807 261 9 involved involve VERB bam-1807 261 10 in in ADP bam-1807 261 11 the the DET bam-1807 261 12 up up NOUN bam-1807 261 13 - - PUNCT bam-1807 261 14 regulation regulation NOUN bam-1807 261 15 of of ADP bam-1807 261 16 antioxidant antioxidant ADJ bam-1807 261 17 enzymes enzyme NOUN bam-1807 261 18 ( ( PUNCT bam-1807 261 19 discussed discuss VERB bam-1807 261 20 in in ADP bam-1807 261 21 brooks brooks PROPN bam-1807 261 22 et et PROPN bam-1807 261 23 al al PROPN bam-1807 261 24 . . PROPN bam-1807 261 25 , , PUNCT bam-1807 262 1 [ [ X bam-1807 262 2 13 13 NUM bam-1807 262 3 ] ] NUM bam-1807 262 4 ) ) PUNCT bam-1807 262 5 . . PUNCT bam-1807 263 1 in in ADP bam-1807 263 2 the the DET bam-1807 263 3 muscles muscle NOUN bam-1807 263 4 of of ADP bam-1807 263 5 chronically chronically ADV bam-1807 263 6 exercised exercise VERB bam-1807 263 7 male male ADJ bam-1807 263 8 mice mouse NOUN bam-1807 263 9 , , PUNCT bam-1807 263 10 the the DET bam-1807 263 11 basal basal ADJ bam-1807 263 12 level level NOUN bam-1807 263 13 of of ADP bam-1807 263 14 nfκb nfκb NOUN bam-1807 263 15 binding bind VERB bam-1807 263 16 to to ADP bam-1807 263 17 dna dna PROPN bam-1807 263 18 was be AUX bam-1807 263 19 shown show VERB bam-1807 263 20 to to PART bam-1807 263 21 be be AUX bam-1807 263 22 higher high ADJ bam-1807 263 23 than than ADP bam-1807 263 24 in in ADP bam-1807 263 25 the the DET bam-1807 263 26 muscles muscle NOUN bam-1807 263 27 of of ADP bam-1807 263 28 sedentary sedentary ADJ bam-1807 263 29 ones one NOUN bam-1807 263 30 and and CCONJ bam-1807 263 31 this this PRON bam-1807 263 32 correlated correlate VERB bam-1807 263 33 with with ADP bam-1807 263 34 the the DET bam-1807 263 35 ability ability NOUN bam-1807 263 36 of of ADP bam-1807 263 37 exercise exercise NOUN bam-1807 263 38 - - PUNCT bam-1807 263 39 conditioned condition VERB bam-1807 263 40 muscles muscle NOUN bam-1807 263 41 to to PART bam-1807 263 42 detoxify detoxify VERB bam-1807 263 43 ros ros PROPN bam-1807 264 1 [ [ X bam-1807 264 2 13 13 NUM bam-1807 264 3 ] ] PUNCT bam-1807 264 4 , , PUNCT bam-1807 264 5 providing provide VERB bam-1807 264 6 protection protection NOUN bam-1807 264 7 from from ADP bam-1807 264 8 ros ros PROPN bam-1807 264 9 - - PUNCT bam-1807 264 10 induced induce VERB bam-1807 264 11 damage damage NOUN bam-1807 264 12 and and CCONJ bam-1807 264 13 from from ADP bam-1807 264 14 ros ros PROPN bam-1807 264 15 accumulation accumulation NOUN bam-1807 264 16 . . PUNCT bam-1807 265 1 although although SCONJ bam-1807 265 2 the the DET bam-1807 265 3 causative causative ADJ bam-1807 265 4 mechanisms mechanism NOUN bam-1807 265 5 have have AUX bam-1807 265 6 not not PART bam-1807 265 7 been be AUX bam-1807 265 8 fully fully ADV bam-1807 265 9 elucidated elucidate VERB bam-1807 265 10 , , PUNCT bam-1807 265 11 it it PRON bam-1807 265 12 was be AUX bam-1807 265 13 also also ADV bam-1807 265 14 shown show VERB bam-1807 265 15 that that DET bam-1807 265 16 muscle muscle NOUN bam-1807 265 17 's 's PART bam-1807 265 18 antioxidant antioxidant ADJ bam-1807 265 19 capacity capacity NOUN bam-1807 265 20 , , PUNCT bam-1807 265 21 potentiated potentiate VERB bam-1807 265 22 by by ADP bam-1807 265 23 chronic chronic ADJ bam-1807 265 24 endurance endurance NOUN bam-1807 265 25 exercise exercise NOUN bam-1807 265 26 , , PUNCT bam-1807 265 27 decreases decrease VERB bam-1807 265 28 the the DET bam-1807 265 29 expression expression NOUN bam-1807 265 30 of of ADP bam-1807 265 31 the the DET bam-1807 265 32 pro pro ADJ bam-1807 265 33 - - ADJ bam-1807 265 34 apoptotic apoptotic ADJ bam-1807 265 35 gene gene NOUN bam-1807 265 36 bax bax PROPN bam-1807 265 37 and and CCONJ bam-1807 265 38 increases increase VERB bam-1807 265 39 that that PRON bam-1807 265 40 of of ADP bam-1807 265 41 the the DET bam-1807 265 42 anti anti ADJ bam-1807 265 43 - - ADJ bam-1807 265 44 apoptotic apoptotic ADJ bam-1807 265 45 bcl-2 bcl-2 NOUN bam-1807 265 46 [ [ X bam-1807 265 47 1 1 NUM bam-1807 265 48 , , PUNCT bam-1807 265 49 107 107 NUM bam-1807 265 50 ] ] PUNCT bam-1807 265 51 . . PUNCT bam-1807 266 1 a a DET bam-1807 266 2 clue clue NOUN bam-1807 266 3 for for ADP bam-1807 266 4 understanding understand VERB bam-1807 266 5 the the DET bam-1807 266 6 antiapoptotic antiapoptotic ADJ bam-1807 266 7 effects effect NOUN bam-1807 266 8 of of ADP bam-1807 266 9 exercise exercise NOUN bam-1807 266 10 may may AUX bam-1807 266 11 actually actually ADV bam-1807 266 12 come come VERB bam-1807 266 13 from from ADP bam-1807 266 14 the the DET bam-1807 266 15 observation observation NOUN bam-1807 266 16 that that PRON bam-1807 266 17 exercise exercise NOUN bam-1807 266 18 upregulates upregulate VERB bam-1807 266 19 some some DET bam-1807 266 20 enzymes enzyme NOUN bam-1807 266 21 involved involve VERB bam-1807 266 22 in in ADP bam-1807 266 23 dna dna PROPN bam-1807 266 24 repair repair NOUN bam-1807 266 25 [ [ X bam-1807 266 26 87 87 NUM bam-1807 266 27 ] ] PUNCT bam-1807 266 28 , , PUNCT bam-1807 266 29 thus thus ADV bam-1807 266 30 decreasing decrease VERB bam-1807 266 31 the the DET bam-1807 266 32 likelihood likelihood NOUN bam-1807 266 33 of of ADP bam-1807 266 34 damaged damage VERB bam-1807 266 35 dna dna NOUN bam-1807 266 36 to to PART bam-1807 266 37 initiate initiate VERB bam-1807 266 38 a a DET bam-1807 266 39 p53 p53 NOUN bam-1807 266 40 - - PUNCT bam-1807 266 41 mediated mediate VERB bam-1807 266 42 apoptotic apoptotic ADJ bam-1807 266 43 cascade cascade NOUN bam-1807 266 44 . . PUNCT bam-1807 267 1 noteworthy noteworthy ADJ bam-1807 267 2 , , PUNCT bam-1807 267 3 dna dna ADJ bam-1807 267 4 damage damage NOUN bam-1807 267 5 may may AUX bam-1807 267 6 result result VERB bam-1807 267 7 from from ADP bam-1807 267 8 cell cell NOUN bam-1807 267 9 exposure exposure NOUN bam-1807 267 10 to to ADP bam-1807 267 11 ros ros PROPN bam-1807 267 12 , , PUNCT bam-1807 267 13 but but CCONJ bam-1807 267 14 dna dna PROPN bam-1807 267 15 damage damage NOUN bam-1807 267 16 of of ADP bam-1807 267 17 long long ADV bam-1807 267 18 - - PUNCT bam-1807 267 19 lived live VERB bam-1807 267 20 skeletal skeletal ADJ bam-1807 267 21 muscle muscle NOUN bam-1807 267 22 cells cell NOUN bam-1807 267 23 is be AUX bam-1807 267 24 also also ADV bam-1807 267 25 associated associate VERB bam-1807 267 26 with with ADP bam-1807 267 27 aging age VERB bam-1807 267 28 . . PUNCT bam-1807 268 1 exercise exercise NOUN bam-1807 268 2 and and CCONJ bam-1807 268 3 its its PRON bam-1807 268 4 associated associated ADJ bam-1807 268 5 ros ros PROPN bam-1807 268 6 generation generation NOUN bam-1807 268 7 also also ADV bam-1807 268 8 transiently transiently ADV bam-1807 268 9 induce induce VERB bam-1807 268 10 the the DET bam-1807 268 11 production production NOUN bam-1807 268 12 of of ADP bam-1807 268 13 some some DET bam-1807 268 14 inflammatory inflammatory ADJ bam-1807 268 15 cytokines cytokine NOUN bam-1807 268 16 in in ADP bam-1807 268 17 skeletal skeletal ADJ bam-1807 268 18 muscle muscle NOUN bam-1807 268 19 ( ( PUNCT bam-1807 268 20 reviewed review VERB bam-1807 268 21 by by ADP bam-1807 268 22 pedersen pedersen NOUN bam-1807 268 23 and and CCONJ bam-1807 268 24 febbraio febbraio ADJ bam-1807 268 25 [ [ X bam-1807 268 26 81 81 NUM bam-1807 268 27 ] ] PUNCT bam-1807 268 28 and and CCONJ bam-1807 268 29 scheele scheele PROPN bam-1807 268 30 et et PROPN bam-1807 268 31 al al PROPN bam-1807 268 32 . . PROPN bam-1807 268 33 , , PUNCT bam-1807 269 1 [ [ X bam-1807 269 2 99 99 NUM bam-1807 269 3 ] ] PUNCT bam-1807 269 4 ) ) PUNCT bam-1807 269 5 . . PUNCT bam-1807 270 1 in in ADP bam-1807 270 2 a a DET bam-1807 270 3 similar similar ADJ bam-1807 270 4 way way NOUN bam-1807 270 5 as as SCONJ bam-1807 270 6 exercise exercise NOUN bam-1807 270 7 - - PUNCT bam-1807 270 8 induced induce VERB bam-1807 270 9 ros ros PROPN bam-1807 270 10 production production NOUN bam-1807 270 11 was be AUX bam-1807 270 12 initially initially ADV bam-1807 270 13 regarded regard VERB bam-1807 270 14 as as ADP bam-1807 270 15 a a DET bam-1807 270 16 damage damage NOUN bam-1807 270 17 - - PUNCT bam-1807 270 18 inducing induce VERB bam-1807 270 19 phenomenon phenomenon NOUN bam-1807 270 20 , , PUNCT bam-1807 270 21 the the DET bam-1807 270 22 initial initial ADJ bam-1807 270 23 view view NOUN bam-1807 270 24 was be AUX bam-1807 270 25 that that SCONJ bam-1807 270 26 these these DET bam-1807 270 27 cytokines cytokine NOUN bam-1807 270 28 were be AUX bam-1807 270 29 a a DET bam-1807 270 30 true true ADJ bam-1807 270 31 sign sign NOUN bam-1807 270 32 of of ADP bam-1807 270 33 exercise exercise NOUN bam-1807 270 34 - - PUNCT bam-1807 270 35 induced induce VERB bam-1807 270 36 inflammation inflammation NOUN bam-1807 270 37 . . PUNCT bam-1807 271 1 it it PRON bam-1807 271 2 now now ADV bam-1807 271 3 appears appear VERB bam-1807 271 4 that that SCONJ bam-1807 271 5 the the DET bam-1807 271 6 so so ADV bam-1807 271 7 - - PUNCT bam-1807 271 8 called call VERB bam-1807 271 9 inflammatory inflammatory ADJ bam-1807 271 10 cytokines cytokine NOUN bam-1807 271 11 may may AUX bam-1807 271 12 have have VERB bam-1807 271 13 different different ADJ bam-1807 271 14 effects effect NOUN bam-1807 271 15 in in ADP bam-1807 271 16 different different ADJ bam-1807 271 17 humoral humoral ADJ bam-1807 271 18 contexts context NOUN bam-1807 271 19 ; ; PUNCT bam-1807 271 20 in in ADP bam-1807 271 21 particular particular ADJ bam-1807 271 22 , , PUNCT bam-1807 271 23 both both CCONJ bam-1807 271 24 upstream upstream ADJ bam-1807 271 25 and and CCONJ bam-1807 271 26 downstream downstream ADJ bam-1807 271 27 signaling signal VERB bam-1807 271 28 pathways pathway NOUN bam-1807 271 29 may may AUX bam-1807 271 30 differ differ VERB bam-1807 271 31 markedly markedly ADV bam-1807 271 32 between between ADP bam-1807 271 33 immune immune NOUN bam-1807 271 34 - - PUNCT bam-1807 271 35 competent competent ADJ bam-1807 271 36 cells cell NOUN bam-1807 271 37 , , PUNCT bam-1807 271 38 muscle muscle NOUN bam-1807 271 39 cells cell NOUN bam-1807 271 40 and and CCONJ bam-1807 271 41 other other ADJ bam-1807 271 42 cells cell NOUN bam-1807 271 43 , , PUNCT bam-1807 271 44 such such ADJ bam-1807 271 45 as as ADP bam-1807 271 46 the the DET bam-1807 271 47 adipocytes adipocyte NOUN bam-1807 271 48 [ [ X bam-1807 271 49 92 92 NUM bam-1807 271 50 ] ] PUNCT bam-1807 271 51 . . PUNCT bam-1807 272 1 in in ADP bam-1807 272 2 healthy healthy ADJ bam-1807 272 3 , , PUNCT bam-1807 272 4 exercised exercise VERB bam-1807 272 5 skeletal skeletal ADJ bam-1807 272 6 muscle muscle NOUN bam-1807 272 7 , , PUNCT bam-1807 272 8 these these DET bam-1807 272 9 muscle muscle NOUN bam-1807 272 10 - - PUNCT bam-1807 272 11 derived derive VERB bam-1807 272 12 cytokines cytokine NOUN bam-1807 272 13 , , PUNCT bam-1807 272 14 renamed rename VERB bam-1807 272 15 “ " PUNCT bam-1807 272 16 myokines myokine NOUN bam-1807 272 17 ” " PUNCT bam-1807 272 18 , , PUNCT bam-1807 272 19 are be AUX bam-1807 272 20 now now ADV bam-1807 272 21 recognized recognize VERB bam-1807 272 22 to to PART bam-1807 272 23 possess possess VERB bam-1807 272 24 important important ADJ bam-1807 272 25 anti anti ADJ bam-1807 272 26 - - ADJ bam-1807 272 27 inflammatory inflammatory ADJ bam-1807 272 28 and and CCONJ bam-1807 272 29 metabolic metabolic NOUN bam-1807 272 30 properties property NOUN bam-1807 272 31 and and CCONJ bam-1807 272 32 to to PART bam-1807 272 33 exert exert VERB bam-1807 272 34 multiple multiple ADJ bam-1807 272 35 beneficial beneficial ADJ bam-1807 272 36 effects effect NOUN bam-1807 272 37 , , PUNCT bam-1807 272 38 both both CCONJ bam-1807 272 39 local local ADJ bam-1807 272 40 and and CCONJ bam-1807 272 41 systemic systemic ADJ bam-1807 272 42 . . PUNCT bam-1807 273 1 for for ADP bam-1807 273 2 instance instance NOUN bam-1807 273 3 , , PUNCT bam-1807 273 4 il-6 il-6 PRON bam-1807 273 5 exerts exert VERB bam-1807 273 6 inhibitory inhibitory ADJ bam-1807 273 7 effects effect NOUN bam-1807 273 8 on on ADP bam-1807 273 9 tnf tnf PROPN bam-1807 273 10 - - PUNCT bam-1807 273 11 α α PROPN bam-1807 273 12 and and CCONJ bam-1807 273 13 il-1 il-1 ADP bam-1807 273 14 production production NOUN bam-1807 273 15 ; ; PUNCT bam-1807 273 16 il-8 il-8 NOUN bam-1807 273 17 acts act NOUN bam-1807 273 18 as as ADP bam-1807 273 19 an an DET bam-1807 273 20 angiogenic angiogenic ADJ bam-1807 273 21 factor factor NOUN bam-1807 273 22 ; ; PUNCT bam-1807 273 23 il-15 il-15 PUNCT bam-1807 273 24 has have AUX bam-1807 273 25 been be AUX bam-1807 273 26 identified identify VERB bam-1807 273 27 as as ADP bam-1807 273 28 an an DET bam-1807 273 29 anabolic anabolic NOUN bam-1807 273 30 factor factor NOUN bam-1807 273 31 , , PUNCT bam-1807 273 32 which which PRON bam-1807 273 33 stimulates stimulate VERB bam-1807 273 34 myogenic myogenic ADJ bam-1807 273 35 differentiation differentiation NOUN bam-1807 273 36 and and CCONJ bam-1807 273 37 plays play VERB bam-1807 273 38 a a DET bam-1807 273 39 role role NOUN bam-1807 273 40 in in ADP bam-1807 273 41 muscle muscle NOUN bam-1807 273 42 - - PUNCT bam-1807 273 43 adipose adipose NOUN bam-1807 273 44 tissue tissue NOUN bam-1807 273 45 interaction interaction NOUN bam-1807 273 46 [ [ X bam-1807 273 47 81 81 NUM bam-1807 273 48 ] ] PUNCT bam-1807 273 49 . . PUNCT bam-1807 274 1 all all DET bam-1807 274 2 the the DET bam-1807 274 3 above above ADJ bam-1807 274 4 described describe VERB bam-1807 274 5 adaptations adaptation NOUN bam-1807 274 6 to to ADP bam-1807 274 7 ros ros PROPN bam-1807 274 8 may may AUX bam-1807 274 9 be be AUX bam-1807 274 10 considered consider VERB bam-1807 274 11 a a DET bam-1807 274 12 sort sort NOUN bam-1807 274 13 of of ADV bam-1807 274 14 preconditioning preconditioning NOUN bam-1807 274 15 that that PRON bam-1807 274 16 may may AUX bam-1807 274 17 explain explain VERB bam-1807 274 18 why why SCONJ bam-1807 274 19 trained train VERB bam-1807 274 20 muscle muscle NOUN bam-1807 274 21 is be AUX bam-1807 274 22 less less ADV bam-1807 274 23 subjected subject VERB bam-1807 274 24 to to ADP bam-1807 274 25 exerciseinduced exerciseinduce VERB bam-1807 274 26 damage damage NOUN bam-1807 274 27 and and CCONJ bam-1807 274 28 underlines underline VERB bam-1807 274 29 the the DET bam-1807 274 30 beneficial beneficial ADJ bam-1807 274 31 effects effect NOUN bam-1807 274 32 that that SCONJ bam-1807 274 33 a a DET bam-1807 274 34 moderate moderate ADJ bam-1807 274 35 amount amount NOUN bam-1807 274 36 of of ADP bam-1807 274 37 exercise exercise NOUN bam-1807 274 38 - - PUNCT bam-1807 274 39 induced induce VERB bam-1807 274 40 ros ros PROPN bam-1807 274 41 may may AUX bam-1807 274 42 have have VERB bam-1807 274 43 in in ADP bam-1807 274 44 the the DET bam-1807 274 45 prevention prevention NOUN bam-1807 274 46 of of ADP bam-1807 274 47 damage damage NOUN bam-1807 274 48 caused cause VERB bam-1807 274 49 by by ADP bam-1807 274 50 more more ADV bam-1807 274 51 strenuous strenuous ADJ bam-1807 274 52 or or CCONJ bam-1807 274 53 potentially potentially ADV bam-1807 274 54 dangerous dangerous ADJ bam-1807 274 55 exercise exercise NOUN bam-1807 274 56 . . PUNCT bam-1807 275 1 8 8 X bam-1807 275 2 . . X bam-1807 275 3 exercise exercise NOUN bam-1807 275 4 and and CCONJ bam-1807 275 5 skeletal skeletal ADJ bam-1807 275 6 muscle muscle NOUN bam-1807 275 7 cell cell NOUN bam-1807 275 8 damage damage NOUN bam-1807 275 9 strenuous strenuous ADJ bam-1807 275 10 and and CCONJ bam-1807 275 11 , , PUNCT bam-1807 275 12 in in ADP bam-1807 275 13 particular particular ADJ bam-1807 275 14 , , PUNCT bam-1807 275 15 eccentric eccentric ADJ bam-1807 275 16 exercise exercise NOUN bam-1807 275 17 may may AUX bam-1807 275 18 result result VERB bam-1807 275 19 in in ADP bam-1807 275 20 skeletal skeletal ADJ bam-1807 275 21 muscle muscle NOUN bam-1807 275 22 cell cell NOUN bam-1807 275 23 damage damage NOUN bam-1807 275 24 , , PUNCT bam-1807 275 25 which which PRON bam-1807 275 26 may may AUX bam-1807 275 27 manifest manifest VERB bam-1807 275 28 itself itself PRON bam-1807 275 29 with with ADP bam-1807 275 30 ldh ldh NOUN bam-1807 275 31 release release NOUN bam-1807 275 32 from from ADP bam-1807 275 33 the the DET bam-1807 275 34 cell cell NOUN bam-1807 275 35 membrane membrane NOUN bam-1807 275 36 and/or and/or CCONJ bam-1807 275 37 apoptosis apoptosis NOUN bam-1807 275 38 . . PUNCT bam-1807 276 1 both both DET bam-1807 276 2 muscle muscle NOUN bam-1807 276 3 cell cell NOUN bam-1807 276 4 damage damage NOUN bam-1807 276 5 [ [ X bam-1807 276 6 95 95 NUM bam-1807 276 7 , , PUNCT bam-1807 276 8 96 96 NUM bam-1807 276 9 ] ] PUNCT bam-1807 276 10 and and CCONJ bam-1807 276 11 exercise exercise NOUN bam-1807 276 12 - - PUNCT bam-1807 276 13 induced induce VERB bam-1807 276 14 oxidative oxidative ADJ bam-1807 276 15 stress stress NOUN bam-1807 276 16 [ [ X bam-1807 276 17 80 80 NUM bam-1807 276 18 ] ] PUNCT bam-1807 276 19 have have AUX bam-1807 276 20 been be AUX bam-1807 276 21 associated associate VERB bam-1807 276 22 with with ADP bam-1807 276 23 apoptosis apoptosis NOUN bam-1807 276 24 ; ; PUNCT bam-1807 276 25 at at ADP bam-1807 276 26 the the DET bam-1807 276 27 same same ADJ bam-1807 276 28 time time NOUN bam-1807 276 29 , , PUNCT bam-1807 276 30 fatigue fatigue NOUN bam-1807 276 31 , , PUNCT bam-1807 276 32 which which PRON bam-1807 276 33 may may AUX bam-1807 276 34 be be AUX bam-1807 276 35 per per ADP bam-1807 276 36 se se X bam-1807 276 37 a a DET bam-1807 276 38 symptom symptom NOUN bam-1807 276 39 of of ADP bam-1807 276 40 skeletal skeletal ADJ bam-1807 276 41 muscle muscle NOUN bam-1807 276 42 cell cell NOUN bam-1807 276 43 damage damage NOUN bam-1807 276 44 , , PUNCT bam-1807 276 45 has have AUX bam-1807 276 46 been be AUX bam-1807 276 47 associated associate VERB bam-1807 276 48 with with ADP bam-1807 276 49 oxidative oxidative ADJ bam-1807 276 50 stress stress NOUN bam-1807 276 51 [ [ X bam-1807 276 52 73 73 NUM bam-1807 276 53 ] ] PUNCT bam-1807 276 54 . . PUNCT bam-1807 277 1 it it PRON bam-1807 277 2 is be AUX bam-1807 277 3 nevertheless nevertheless ADV bam-1807 277 4 controversial controversial ADJ bam-1807 277 5 whether whether SCONJ bam-1807 277 6 strenuous strenuous ADJ bam-1807 277 7 exercise exercise NOUN bam-1807 277 8 does do AUX bam-1807 277 9 in in ADP bam-1807 277 10 effect effect NOUN bam-1807 277 11 cause cause VERB bam-1807 277 12 oxidative oxidative ADJ bam-1807 277 13 stress stress NOUN bam-1807 277 14 ; ; PUNCT bam-1807 277 15 in in ADP bam-1807 277 16 fact fact NOUN bam-1807 277 17 , , PUNCT bam-1807 277 18 while while SCONJ bam-1807 277 19 selman selman PROPN bam-1807 277 20 et et PROPN bam-1807 277 21 al al PROPN bam-1807 278 1 [ [ X bam-1807 278 2 104 104 NUM bam-1807 278 3 ] ] PUNCT bam-1807 278 4 failed fail VERB bam-1807 278 5 to to PART bam-1807 278 6 find find VERB bam-1807 278 7 significant significant ADJ bam-1807 278 8 increases increase NOUN bam-1807 278 9 in in ADP bam-1807 278 10 lipid lipid NOUN bam-1807 278 11 peroxidation peroxidation NOUN bam-1807 278 12 products product NOUN bam-1807 278 13 following follow VERB bam-1807 278 14 strenuous strenuous ADJ bam-1807 278 15 exercise exercise NOUN bam-1807 278 16 in in ADP bam-1807 278 17 the the DET bam-1807 278 18 field field NOUN bam-1807 278 19 mole mole NOUN bam-1807 278 20 , , PUNCT bam-1807 278 21 marini marini PROPN bam-1807 278 22 et et PROPN bam-1807 278 23 al al PROPN bam-1807 278 24 . . PUNCT bam-1807 279 1 [ [ X bam-1807 279 2 67 67 NUM bam-1807 279 3 ] ] PUNCT bam-1807 279 4 reported report VERB bam-1807 279 5 a a DET bam-1807 279 6 significant significant ADJ bam-1807 279 7 increase increase NOUN bam-1807 279 8 in in ADP bam-1807 279 9 plasmatic plasmatic ADJ bam-1807 279 10 malondialdehyde malondialdehyde NOUN bam-1807 279 11 levels level NOUN bam-1807 279 12 in in ADP bam-1807 279 13 moderately moderately ADV bam-1807 279 14 trained train VERB bam-1807 279 15 rats rat NOUN bam-1807 279 16 . . PUNCT bam-1807 280 1 whether whether SCONJ bam-1807 280 2 the the DET bam-1807 280 3 presence presence NOUN bam-1807 280 4 of of ADP bam-1807 280 5 peroxidation peroxidation NOUN bam-1807 280 6 products product NOUN bam-1807 280 7 should should AUX bam-1807 280 8 be be AUX bam-1807 280 9 considered consider VERB bam-1807 280 10 a a DET bam-1807 280 11 proof proof NOUN bam-1807 280 12 of of ADP bam-1807 280 13 oxidative oxidative ADJ bam-1807 280 14 stress stress NOUN bam-1807 280 15 is be AUX bam-1807 280 16 however however ADV bam-1807 280 17 questionable questionable ADJ bam-1807 280 18 . . PUNCT bam-1807 281 1 on on ADP bam-1807 281 2 the the DET bam-1807 281 3 other other ADJ bam-1807 281 4 hand hand NOUN bam-1807 281 5 , , PUNCT bam-1807 281 6 it it PRON bam-1807 281 7 is be AUX bam-1807 281 8 possible possible ADJ bam-1807 281 9 that that SCONJ bam-1807 281 10 the the DET bam-1807 281 11 pro pro ADJ bam-1807 281 12 - - ADJ bam-1807 281 13 oxidant oxidant ADJ bam-1807 281 14 environment environment NOUN bam-1807 281 15 generated generate VERB bam-1807 281 16 in in ADP bam-1807 281 17 the the DET bam-1807 281 18 active active ADJ bam-1807 281 19 muscle muscle NOUN bam-1807 281 20 , , PUNCT bam-1807 281 21 in in ADP bam-1807 281 22 the the DET bam-1807 281 23 presence presence NOUN bam-1807 281 24 of of ADP bam-1807 281 25 inadequate inadequate ADJ bam-1807 281 26 local local ADJ bam-1807 281 27 amounts amount NOUN bam-1807 281 28 of of ADP bam-1807 281 29 anti anti NOUN bam-1807 281 30 - - NOUN bam-1807 281 31 oxidants oxidant NOUN bam-1807 281 32 , , PUNCT bam-1807 281 33 may may AUX bam-1807 281 34 in in ADP bam-1807 281 35 some some DET bam-1807 281 36 circumstances circumstance NOUN bam-1807 281 37 lead lead VERB bam-1807 281 38 to to ADP bam-1807 281 39 skeletal skeletal ADJ bam-1807 281 40 muscle muscle NOUN bam-1807 281 41 cell cell NOUN bam-1807 281 42 damage damage NOUN bam-1807 281 43 through through ADP bam-1807 281 44 a a DET bam-1807 281 45 ca2 ca2 PROPN bam-1807 281 46 + + PROPN bam-1807 281 47 -mediated -mediate VERB bam-1807 281 48 mechanism mechanism NOUN bam-1807 281 49 . . PUNCT bam-1807 282 1 this this DET bam-1807 282 2 hypothesis hypothesis NOUN bam-1807 282 3 is be AUX bam-1807 282 4 based base VERB bam-1807 282 5 on on ADP bam-1807 282 6 the the DET bam-1807 282 7 current current ADJ bam-1807 282 8 view view NOUN bam-1807 282 9 that that SCONJ bam-1807 282 10 , , PUNCT bam-1807 282 11 rather rather ADV bam-1807 282 12 than than ADP bam-1807 282 13 individual individual ADJ bam-1807 282 14 organels organel NOUN bam-1807 282 15 , , PUNCT bam-1807 282 16 mitochondria mitochondria PROPN bam-1807 282 17 may may AUX bam-1807 282 18 be be AUX bam-1807 282 19 considered consider VERB bam-1807 282 20 as as ADP bam-1807 282 21 a a DET bam-1807 282 22 complex complex ADJ bam-1807 282 23 and and CCONJ bam-1807 282 24 dynamic dynamic ADJ bam-1807 282 25 network network NOUN bam-1807 282 26 , , PUNCT bam-1807 282 27 which which PRON bam-1807 282 28 may may AUX bam-1807 282 29 form form VERB bam-1807 282 30 junctions junction NOUN bam-1807 282 31 with with ADP bam-1807 282 32 the the DET bam-1807 282 33 sarco sarco NOUN bam-1807 282 34 - - PUNCT bam-1807 282 35 endoplasmic endoplasmic ADJ bam-1807 282 36 reticulum reticulum NOUN bam-1807 282 37 ( ( PUNCT bam-1807 282 38 sr sr PROPN bam-1807 282 39 / / SYM bam-1807 282 40 er er INTJ bam-1807 282 41 ) ) PUNCT bam-1807 282 42 . . PUNCT bam-1807 283 1 the the DET bam-1807 283 2 close close ADJ bam-1807 283 3 proximity proximity NOUN bam-1807 283 4 of of ADP bam-1807 283 5 the the DET bam-1807 283 6 two two NUM bam-1807 283 7 intracellular intracellular ADJ bam-1807 283 8 membrane membrane NOUN bam-1807 283 9 systems system NOUN bam-1807 283 10 ( ( PUNCT bam-1807 283 11 gap gap NOUN bam-1807 283 12 is be AUX bam-1807 283 13 estimated estimate VERB bam-1807 283 14 to to PART bam-1807 283 15 be be AUX bam-1807 283 16 10 10 NUM bam-1807 283 17 - - SYM bam-1807 283 18 50 50 NUM bam-1807 283 19 nm nm ADV bam-1807 283 20 wide wide ADV bam-1807 283 21 ) ) PUNCT bam-1807 283 22 allows allow VERB bam-1807 283 23 for for ADP bam-1807 283 24 collaboration collaboration NOUN bam-1807 283 25 in in ADP bam-1807 283 26 lipid lipid NOUN bam-1807 283 27 biosynthesis biosynthesis NOUN bam-1807 283 28 as as ADV bam-1807 283 29 well well ADV bam-1807 283 30 as as ADP bam-1807 283 31 for for ADP bam-1807 283 32 local local ADJ bam-1807 283 33 exchanges exchange NOUN bam-1807 283 34 of of ADP bam-1807 283 35 signals signal NOUN bam-1807 283 36 , , PUNCT bam-1807 283 37 including include VERB bam-1807 283 38 ca2 ca2 PROPN bam-1807 283 39 + + PROPN bam-1807 283 40 and and CCONJ bam-1807 283 41 ros ros PROPN bam-1807 283 42 . . PUNCT bam-1807 284 1 in in ADP bam-1807 284 2 particular particular ADJ bam-1807 284 3 , , PUNCT bam-1807 284 4 ros ros PROPN bam-1807 284 5 production production NOUN bam-1807 284 6 within within ADP bam-1807 284 7 mitochondria mitochondria NOUN bam-1807 284 8 may may AUX bam-1807 284 9 directly directly ADV bam-1807 284 10 affect affect VERB bam-1807 284 11 ca2 ca2 PROPN bam-1807 284 12 + + ADJ bam-1807 284 13 -handling -handle VERB bam-1807 284 14 molecules molecule NOUN bam-1807 284 15 on on ADP bam-1807 284 16 sr sr PROPN bam-1807 284 17 / / SYM bam-1807 284 18 er er INTJ bam-1807 284 19 . . PUNCT bam-1807 284 20 serca serca PROPN bam-1807 284 21 , , PUNCT bam-1807 284 22 ryr1 ryr1 NOUN bam-1807 284 23 and and CCONJ bam-1807 284 24 ip3r ip3r PROPN bam-1807 284 25 all all PRON bam-1807 284 26 contain contain VERB bam-1807 284 27 multiple multiple ADJ bam-1807 284 28 cys cys NOUN bam-1807 284 29 residues residue NOUN bam-1807 284 30 , , PUNCT bam-1807 284 31 some some PRON bam-1807 284 32 of of ADP bam-1807 284 33 which which PRON bam-1807 284 34 are be AUX bam-1807 284 35 bona bona ADJ bam-1807 284 36 fide fide ADJ bam-1807 284 37 sensors sensor NOUN bam-1807 284 38 of of ADP bam-1807 284 39 the the DET bam-1807 284 40 cell cell NOUN bam-1807 284 41 's 's PART bam-1807 284 42 oxidative oxidative ADJ bam-1807 284 43 stress stress NOUN bam-1807 284 44 . . PUNCT bam-1807 285 1 interestingly interestingly ADV bam-1807 285 2 , , PUNCT bam-1807 285 3 low low ADJ bam-1807 285 4 level level NOUN bam-1807 285 5 ros ros PROPN bam-1807 285 6 production production NOUN bam-1807 285 7 by by ADP bam-1807 285 8 adjacent adjacent ADJ bam-1807 285 9 mitochondria mitochondria PROPN bam-1807 285 10 is be AUX bam-1807 285 11 likely likely ADJ bam-1807 285 12 to to PART bam-1807 285 13 facilitate facilitate VERB bam-1807 285 14 serca serca NOUN bam-1807 285 15 activity activity NOUN bam-1807 285 16 , , PUNCT bam-1807 285 17 whereas whereas SCONJ bam-1807 285 18 massive massive ADJ bam-1807 285 19 ros ros PROPN bam-1807 285 20 generation generation NOUN bam-1807 285 21 would would AUX bam-1807 285 22 affect affect VERB bam-1807 285 23 the the DET bam-1807 285 24 functionality functionality NOUN bam-1807 285 25 of of ADP bam-1807 285 26 ca2 ca2 PROPN bam-1807 285 27 + + NOUN bam-1807 285 28 pumps pump NOUN bam-1807 285 29 and and CCONJ bam-1807 285 30 engage engage VERB bam-1807 285 31 ca2 ca2 PROPN bam-1807 285 32 + + NOUN bam-1807 285 33 depletion depletion NOUN bam-1807 285 34 - - PUNCT bam-1807 285 35 induced induce VERB bam-1807 285 36 er er INTJ bam-1807 285 37 stress stress NOUN bam-1807 285 38 that that PRON bam-1807 285 39 may may AUX bam-1807 285 40 synergize synergize VERB bam-1807 285 41 with with ADP bam-1807 285 42 other other ADJ bam-1807 285 43 effectors effector NOUN bam-1807 285 44 to to PART bam-1807 285 45 initiate initiate VERB bam-1807 285 46 apoptosis apoptosis NOUN bam-1807 286 1 [ [ X bam-1807 286 2 17 17 NUM bam-1807 286 3 ] ] PUNCT bam-1807 286 4 . . PUNCT bam-1807 287 1 toxic toxic ADJ bam-1807 287 2 effects effect NOUN bam-1807 287 3 of of ADP bam-1807 287 4 [ [ X bam-1807 287 5 ca2 ca2 PROPN bam-1807 287 6 + + PROPN bam-1807 287 7 ] ] X bam-1807 287 8 cyt cyt NOUN bam-1807 287 9 increase increase NOUN bam-1807 287 10 in in ADP bam-1807 287 11 skeletal skeletal ADJ bam-1807 287 12 muscle muscle NOUN bam-1807 287 13 cells cell NOUN bam-1807 287 14 have have AUX bam-1807 287 15 actually actually ADV bam-1807 287 16 been be AUX bam-1807 287 17 observed observe VERB bam-1807 287 18 in in ADP bam-1807 287 19 a a DET bam-1807 287 20 number number NOUN bam-1807 287 21 of of ADP bam-1807 287 22 pathological pathological ADJ bam-1807 287 23 conditions condition NOUN bam-1807 287 24 ( ( PUNCT bam-1807 287 25 see see VERB bam-1807 287 26 , , PUNCT bam-1807 287 27 for for ADP bam-1807 287 28 example example NOUN bam-1807 287 29 , , PUNCT bam-1807 287 30 the the DET bam-1807 287 31 exercised exercise VERB bam-1807 287 32 skeletal skeletal ADJ bam-1807 287 33 muscle muscle NOUN bam-1807 287 34 european european PROPN bam-1807 287 35 journal journal PROPN bam-1807 287 36 translational translational ADJ bam-1807 287 37 myology myology NOUN bam-1807 287 38 myology myology NOUN bam-1807 287 39 reviews review VERB bam-1807 287 40 20 20 NUM bam-1807 287 41 ( ( PUNCT bam-1807 287 42 3 3 NUM bam-1807 287 43 ): ): PUNCT bam-1807 287 44 105 105 NUM bam-1807 287 45 - - SYM bam-1807 287 46 120 120 NUM bam-1807 287 47 , , PUNCT bam-1807 287 48 2010 2010 NUM bam-1807 287 49 114 114 NUM bam-1807 288 1 [ [ X bam-1807 288 2 106 106 NUM bam-1807 288 3 ] ] PUNCT bam-1807 288 4 ) ) PUNCT bam-1807 288 5 ; ; PUNCT bam-1807 288 6 they they PRON bam-1807 288 7 are be AUX bam-1807 288 8 mediated mediate VERB bam-1807 288 9 , , PUNCT bam-1807 288 10 among among ADP bam-1807 288 11 others other NOUN bam-1807 288 12 mechanisms mechanism NOUN bam-1807 288 13 , , PUNCT bam-1807 288 14 by by ADP bam-1807 288 15 the the DET bam-1807 288 16 activation activation NOUN bam-1807 288 17 of of ADP bam-1807 288 18 calpains calpain NOUN bam-1807 288 19 and and CCONJ bam-1807 288 20 may may AUX bam-1807 288 21 lead lead VERB bam-1807 288 22 to to ADP bam-1807 288 23 apoptosis apoptosis VERB bam-1807 288 24 . . PUNCT bam-1807 289 1 the the DET bam-1807 289 2 fact fact NOUN bam-1807 289 3 that that SCONJ bam-1807 289 4 oxidative oxidative ADJ bam-1807 289 5 stress stress NOUN bam-1807 289 6 may may AUX bam-1807 289 7 be be AUX bam-1807 289 8 responsible responsible ADJ bam-1807 289 9 for for ADP bam-1807 289 10 muscle muscle NOUN bam-1807 289 11 soreness soreness NOUN bam-1807 289 12 and and CCONJ bam-1807 289 13 fatigue fatigue NOUN bam-1807 289 14 and and CCONJ bam-1807 289 15 even even ADV bam-1807 289 16 prompt prompt ADJ bam-1807 289 17 to to ADP bam-1807 289 18 skeletal skeletal ADJ bam-1807 289 19 muscle muscle NOUN bam-1807 289 20 damage damage NOUN bam-1807 289 21 has have AUX bam-1807 289 22 suggested suggest VERB bam-1807 289 23 that that SCONJ bam-1807 289 24 anti anti ADJ bam-1807 289 25 - - ADJ bam-1807 289 26 oxidant oxidant ADJ bam-1807 289 27 supplementation supplementation NOUN bam-1807 289 28 may may AUX bam-1807 289 29 relieve relieve VERB bam-1807 289 30 the the DET bam-1807 289 31 problem problem NOUN bam-1807 289 32 . . PUNCT bam-1807 290 1 this this DET bam-1807 290 2 intervention intervention NOUN bam-1807 290 3 has have AUX bam-1807 290 4 been be AUX bam-1807 290 5 addressed address VERB bam-1807 290 6 by by ADP bam-1807 290 7 a a DET bam-1807 290 8 number number NOUN bam-1807 290 9 of of ADP bam-1807 290 10 studies study NOUN bam-1807 290 11 , , PUNCT bam-1807 290 12 which which PRON bam-1807 290 13 did do AUX bam-1807 290 14 not not PART bam-1807 290 15 reach reach VERB bam-1807 290 16 incontrovertible incontrovertible ADJ bam-1807 290 17 conclusions conclusion NOUN bam-1807 290 18 . . PUNCT bam-1807 291 1 among among ADP bam-1807 291 2 the the DET bam-1807 291 3 more more ADV bam-1807 291 4 recent recent ADJ bam-1807 291 5 studies study NOUN bam-1807 291 6 , , PUNCT bam-1807 291 7 howatson howatson NOUN bam-1807 291 8 and and CCONJ bam-1807 291 9 van van PROPN bam-1807 291 10 someren someren PROPN bam-1807 292 1 [ [ X bam-1807 292 2 44 44 NUM bam-1807 292 3 ] ] PUNCT bam-1807 292 4 concluded conclude VERB bam-1807 292 5 that that SCONJ bam-1807 292 6 previous previous ADJ bam-1807 292 7 bouts bout NOUN bam-1807 292 8 of of ADP bam-1807 292 9 exercise exercise NOUN bam-1807 292 10 may may AUX bam-1807 292 11 have have VERB bam-1807 292 12 a a DET bam-1807 292 13 safer safe ADJ bam-1807 292 14 and and CCONJ bam-1807 292 15 more more ADV bam-1807 292 16 efficacious efficacious ADJ bam-1807 292 17 effect effect NOUN bam-1807 292 18 on on ADP bam-1807 292 19 exercise exercise NOUN bam-1807 292 20 - - PUNCT bam-1807 292 21 induced induce VERB bam-1807 292 22 muscle muscle NOUN bam-1807 292 23 damage damage NOUN bam-1807 292 24 than than ADP bam-1807 292 25 nutritional nutritional ADJ bam-1807 292 26 and and CCONJ bam-1807 292 27 pharmacological pharmacological ADJ bam-1807 292 28 strategies strategy NOUN bam-1807 292 29 ; ; PUNCT bam-1807 293 1 wray wray PROPN bam-1807 293 2 et et PROPN bam-1807 293 3 al al PROPN bam-1807 293 4 . . PUNCT bam-1807 294 1 [ [ X bam-1807 294 2 120 120 NUM bam-1807 294 3 ] ] PUNCT bam-1807 294 4 examined examine VERB bam-1807 294 5 muscle muscle NOUN bam-1807 294 6 perfusion perfusion NOUN bam-1807 294 7 during during ADP bam-1807 294 8 exercise exercise NOUN bam-1807 294 9 : : PUNCT bam-1807 294 10 while while SCONJ bam-1807 294 11 anti anti ADJ bam-1807 294 12 - - ADJ bam-1807 294 13 oxidant oxidant ADJ bam-1807 294 14 treatment treatment NOUN bam-1807 294 15 improved improve VERB bam-1807 294 16 skeletal skeletal ADJ bam-1807 294 17 muscle muscle NOUN bam-1807 294 18 perfusion perfusion NOUN bam-1807 294 19 of of ADP bam-1807 294 20 the the DET bam-1807 294 21 elders elder NOUN bam-1807 294 22 , , PUNCT bam-1807 294 23 a a DET bam-1807 294 24 negative negative ADJ bam-1807 294 25 effect effect NOUN bam-1807 294 26 in in ADP bam-1807 294 27 young young ADJ bam-1807 294 28 subjects subject NOUN bam-1807 294 29 was be AUX bam-1807 294 30 found find VERB bam-1807 294 31 , , PUNCT bam-1807 294 32 “ " PUNCT bam-1807 294 33 adding add VERB bam-1807 294 34 credence credence NOUN bam-1807 294 35 to to ADP bam-1807 294 36 the the DET bam-1807 294 37 concept concept NOUN bam-1807 294 38 that that SCONJ bam-1807 294 39 some some DET bam-1807 294 40 level level NOUN bam-1807 294 41 of of ADP bam-1807 294 42 free free ADJ bam-1807 294 43 radical radical ADJ bam-1807 294 44 concentration concentration NOUN bam-1807 294 45 is be AUX bam-1807 294 46 essential essential ADJ bam-1807 294 47 for for ADP bam-1807 294 48 normal normal ADJ bam-1807 294 49 function function NOUN bam-1807 294 50 during during ADP bam-1807 294 51 exercise exercise NOUN bam-1807 294 52 in in ADP bam-1807 294 53 young young ADJ bam-1807 294 54 , , PUNCT bam-1807 294 55 healthy healthy ADJ bam-1807 294 56 individuals individual NOUN bam-1807 294 57 ” " PUNCT bam-1807 294 58 . . PUNCT bam-1807 295 1 9 9 X bam-1807 295 2 . . X bam-1807 296 1 the the DET bam-1807 296 2 major major ADJ bam-1807 296 3 pathways pathway NOUN bam-1807 296 4 involved involve VERB bam-1807 296 5 in in ADP bam-1807 296 6 adaptation adaptation NOUN bam-1807 296 7 to to PART bam-1807 296 8 exercise exercise VERB bam-1807 296 9 and and CCONJ bam-1807 296 10 the the DET bam-1807 296 11 phenomenon phenomenon NOUN bam-1807 296 12 of of ADP bam-1807 296 13 concurrent concurrent ADJ bam-1807 296 14 training training NOUN bam-1807 296 15 there there PRON bam-1807 296 16 is be VERB bam-1807 296 17 compelling compelling ADJ bam-1807 296 18 evidence evidence NOUN bam-1807 296 19 that that SCONJ bam-1807 296 20 an an DET bam-1807 296 21 active active ADJ bam-1807 296 22 and and CCONJ bam-1807 296 23 fit fit ADJ bam-1807 296 24 way way NOUN bam-1807 296 25 of of ADP bam-1807 296 26 life life NOUN bam-1807 296 27 has have AUX bam-1807 296 28 many many ADJ bam-1807 296 29 important important ADJ bam-1807 296 30 health health NOUN bam-1807 296 31 benefits benefit NOUN bam-1807 296 32 and and CCONJ bam-1807 296 33 that that PRON bam-1807 296 34 sedentary sedentary ADJ bam-1807 296 35 habits habit NOUN bam-1807 296 36 are be AUX bam-1807 296 37 associated associate VERB bam-1807 296 38 with with ADP bam-1807 296 39 an an DET bam-1807 296 40 increased increase VERB bam-1807 296 41 risk risk NOUN bam-1807 296 42 of of ADP bam-1807 296 43 numerous numerous ADJ bam-1807 296 44 chronic chronic ADJ bam-1807 296 45 diseases disease NOUN bam-1807 296 46 and and CCONJ bam-1807 296 47 decreased decrease VERB bam-1807 296 48 longevity longevity NOUN bam-1807 296 49 ( ( PUNCT bam-1807 296 50 see see VERB bam-1807 296 51 , , PUNCT bam-1807 296 52 for for ADP bam-1807 296 53 instance instance NOUN bam-1807 296 54 , , PUNCT bam-1807 296 55 [ [ X bam-1807 296 56 62 62 NUM bam-1807 296 57 ] ] SYM bam-1807 296 58 ) ) PUNCT bam-1807 296 59 . . PUNCT bam-1807 297 1 current current ADJ bam-1807 297 2 public public ADJ bam-1807 297 3 health health NOUN bam-1807 297 4 recommendations recommendation NOUN bam-1807 297 5 for for ADP bam-1807 297 6 physical physical ADJ bam-1807 297 7 activity activity NOUN bam-1807 297 8 combine combine VERB bam-1807 297 9 aerobic aerobic ADJ bam-1807 297 10 exercise exercise NOUN bam-1807 297 11 with with ADP bam-1807 297 12 resistance resistance NOUN bam-1807 297 13 training training NOUN bam-1807 297 14 and and CCONJ bam-1807 297 15 flexibility flexibility NOUN bam-1807 297 16 exercises exercise NOUN bam-1807 297 17 , , PUNCT bam-1807 297 18 with with ADP bam-1807 297 19 the the DET bam-1807 297 20 aim aim NOUN bam-1807 297 21 of of ADP bam-1807 297 22 promoting promote VERB bam-1807 297 23 the the DET bam-1807 297 24 maintenance maintenance NOUN bam-1807 297 25 of of ADP bam-1807 297 26 lean lean ADJ bam-1807 297 27 body body NOUN bam-1807 297 28 mass mass NOUN bam-1807 297 29 , , PUNCT bam-1807 297 30 improving improve VERB bam-1807 297 31 muscular muscular ADJ bam-1807 297 32 strength strength NOUN bam-1807 297 33 and and CCONJ bam-1807 297 34 endurance endurance NOUN bam-1807 297 35 , , PUNCT bam-1807 297 36 and and CCONJ bam-1807 297 37 preserving preserve VERB bam-1807 297 38 muscle muscle NOUN bam-1807 297 39 and and CCONJ bam-1807 297 40 junction junction NOUN bam-1807 297 41 function function NOUN bam-1807 297 42 , , PUNCT bam-1807 297 43 all all PRON bam-1807 297 44 of of ADP bam-1807 297 45 which which PRON bam-1807 297 46 will will AUX bam-1807 297 47 ultimately ultimately ADV bam-1807 297 48 promote promote VERB bam-1807 297 49 quality quality NOUN bam-1807 297 50 of of ADP bam-1807 297 51 life life NOUN bam-1807 297 52 ( ( PUNCT bam-1807 297 53 see see VERB bam-1807 297 54 , , PUNCT bam-1807 297 55 for for ADP bam-1807 297 56 instance instance NOUN bam-1807 297 57 , , PUNCT bam-1807 297 58 blair blair PROPN bam-1807 297 59 et et PROPN bam-1807 297 60 al al PROPN bam-1807 297 61 . . PROPN bam-1807 297 62 , , PUNCT bam-1807 298 1 [ [ X bam-1807 298 2 9 9 NUM bam-1807 298 3 ] ] SYM bam-1807 298 4 ) ) PUNCT bam-1807 298 5 . . PUNCT bam-1807 299 1 however however ADV bam-1807 299 2 , , PUNCT bam-1807 299 3 what what PRON bam-1807 299 4 is be AUX bam-1807 299 5 good good ADJ bam-1807 299 6 for for ADP bam-1807 299 7 the the DET bam-1807 299 8 general general ADJ bam-1807 299 9 public public NOUN bam-1807 299 10 may may AUX bam-1807 299 11 be be AUX bam-1807 299 12 the the DET bam-1807 299 13 worst bad ADJ bam-1807 299 14 choice choice NOUN bam-1807 299 15 for for ADP bam-1807 299 16 sport sport NOUN bam-1807 299 17 professionals professional NOUN bam-1807 299 18 . . PUNCT bam-1807 300 1 in in ADP bam-1807 300 2 fact fact NOUN bam-1807 300 3 , , PUNCT bam-1807 300 4 the the DET bam-1807 300 5 observation observation NOUN bam-1807 300 6 that that SCONJ bam-1807 300 7 endurance endurance NOUN bam-1807 300 8 and and CCONJ bam-1807 300 9 resistance resistance NOUN bam-1807 300 10 training training NOUN bam-1807 300 11 cause cause VERB bam-1807 300 12 different different ADJ bam-1807 300 13 adaptations adaptation NOUN bam-1807 300 14 in in ADP bam-1807 300 15 skeletal skeletal ADJ bam-1807 300 16 muscle muscle NOUN bam-1807 300 17 suggests suggest VERB bam-1807 300 18 that that SCONJ bam-1807 300 19 simultaneously simultaneously ADV bam-1807 300 20 training train VERB bam-1807 300 21 for for ADP bam-1807 300 22 both both DET bam-1807 300 23 strength strength NOUN bam-1807 300 24 and and CCONJ bam-1807 300 25 endurance endurance NOUN bam-1807 300 26 results result NOUN bam-1807 300 27 in in ADP bam-1807 300 28 a a DET bam-1807 300 29 compromised compromise VERB bam-1807 300 30 adaptation adaptation NOUN bam-1807 300 31 , , PUNCT bam-1807 300 32 compared compare VERB bam-1807 300 33 with with ADP bam-1807 300 34 training training NOUN bam-1807 300 35 for for ADP bam-1807 300 36 either either DET bam-1807 300 37 exercise exercise NOUN bam-1807 300 38 mode mode NOUN bam-1807 300 39 alone alone ADV bam-1807 300 40 . . PUNCT bam-1807 301 1 this this DET bam-1807 301 2 phenomenon phenomenon NOUN bam-1807 301 3 , , PUNCT bam-1807 301 4 named name VERB bam-1807 301 5 “ " PUNCT bam-1807 301 6 concurrent concurrent ADJ bam-1807 301 7 training training NOUN bam-1807 301 8 ” " PUNCT bam-1807 301 9 , , PUNCT bam-1807 301 10 has have AUX bam-1807 301 11 been be AUX bam-1807 301 12 first first ADV bam-1807 301 13 described describe VERB bam-1807 301 14 by by ADP bam-1807 301 15 hickson hickson PROPN bam-1807 302 1 [ [ X bam-1807 302 2 37 37 NUM bam-1807 302 3 ] ] PUNCT bam-1807 302 4 . . PUNCT bam-1807 303 1 by by ADP bam-1807 303 2 utilizing utilize VERB bam-1807 303 3 electrical electrical ADJ bam-1807 303 4 muscle muscle NOUN bam-1807 303 5 stimulation stimulation VERB bam-1807 303 6 mimicking mimic VERB bam-1807 303 7 endurance endurance NOUN bam-1807 303 8 or or CCONJ bam-1807 303 9 resistance resistance NOUN bam-1807 303 10 training training NOUN bam-1807 303 11 , , PUNCT bam-1807 303 12 atherton atherton PROPN bam-1807 303 13 et et PROPN bam-1807 303 14 al al PROPN bam-1807 303 15 . . PUNCT bam-1807 304 1 [ [ X bam-1807 304 2 5 5 NUM bam-1807 304 3 ] ] PUNCT bam-1807 304 4 showed show VERB bam-1807 304 5 that that SCONJ bam-1807 304 6 either either CCONJ bam-1807 304 7 an an DET bam-1807 304 8 ampk ampk NOUN bam-1807 304 9 - - PUNCT bam-1807 304 10 pgc-1αor pgc-1αor VERB bam-1807 304 11 a a DET bam-1807 304 12 pkb pkb PROPN bam-1807 304 13 - - PUNCT bam-1807 304 14 tsc2 tsc2 PROPN bam-1807 304 15 - - PUNCT bam-1807 304 16 mtor mtor NOUN bam-1807 304 17 dominated dominate VERB bam-1807 304 18 state state NOUN bam-1807 304 19 ensued ensue VERB bam-1807 304 20 . . PUNCT bam-1807 305 1 in in ADP bam-1807 305 2 fact fact NOUN bam-1807 305 3 , , PUNCT bam-1807 305 4 there there PRON bam-1807 305 5 is be VERB bam-1807 305 6 molecular molecular ADJ bam-1807 305 7 evidence evidence NOUN bam-1807 305 8 for for ADP bam-1807 305 9 an an DET bam-1807 305 10 interference interference NOUN bam-1807 305 11 effect effect NOUN bam-1807 305 12 when when SCONJ bam-1807 305 13 concurrent concurrent ADJ bam-1807 305 14 training training NOUN bam-1807 305 15 is be AUX bam-1807 305 16 undertaken undertake VERB bam-1807 305 17 [ [ X bam-1807 305 18 36 36 NUM bam-1807 305 19 , , PUNCT bam-1807 305 20 77 77 NUM bam-1807 305 21 ] ] PUNCT bam-1807 305 22 . . PUNCT bam-1807 306 1 interestingly interestingly ADV bam-1807 306 2 , , PUNCT bam-1807 306 3 brief brief ADJ bam-1807 306 4 repeated repeat VERB bam-1807 306 5 sessions session NOUN bam-1807 306 6 of of ADP bam-1807 306 7 high high ADJ bam-1807 306 8 - - PUNCT bam-1807 306 9 intensity intensity NOUN bam-1807 306 10 interval interval NOUN bam-1807 306 11 exercise exercise NOUN bam-1807 306 12 training training NOUN bam-1807 306 13 ( ( PUNCT bam-1807 306 14 hit hit NOUN bam-1807 306 15 ) ) PUNCT bam-1807 306 16 induce induce VERB bam-1807 306 17 phenotypic phenotypic ADJ bam-1807 306 18 changes change NOUN bam-1807 306 19 that that PRON bam-1807 306 20 resemble resemble VERB bam-1807 306 21 traditional traditional ADJ bam-1807 306 22 endurance endurance NOUN bam-1807 306 23 training training NOUN bam-1807 306 24 , , PUNCT bam-1807 306 25 since since SCONJ bam-1807 306 26 signaling signal VERB bam-1807 306 27 through through ADP bam-1807 306 28 amp amp NOUN bam-1807 306 29 - - PUNCT bam-1807 306 30 activated activate VERB bam-1807 306 31 protein protein NOUN bam-1807 306 32 kinase kinase NOUN bam-1807 306 33 and and CCONJ bam-1807 306 34 p38 p38 VERB bam-1807 306 35 mitogen mitogen NOUN bam-1807 306 36 - - PUNCT bam-1807 306 37 activated activate VERB bam-1807 306 38 protein protein NOUN bam-1807 306 39 kinase kinase NOUN bam-1807 306 40 to to ADP bam-1807 306 41 pgc-1a pgc-1a PROPN bam-1807 306 42 , , PUNCT bam-1807 306 43 leading lead VERB bam-1807 306 44 to to ADP bam-1807 306 45 mitochondrial mitochondrial ADJ bam-1807 306 46 biogenesis biogenesis NOUN bam-1807 306 47 , , PUNCT bam-1807 306 48 tend tend VERB bam-1807 306 49 to to PART bam-1807 306 50 prevail prevail VERB bam-1807 306 51 over over ADP bam-1807 306 52 signaling signal VERB bam-1807 306 53 pathways pathway NOUN bam-1807 306 54 linked link VERB bam-1807 306 55 to to ADP bam-1807 306 56 muscle muscle NOUN bam-1807 306 57 growth growth NOUN bam-1807 306 58 , , PUNCT bam-1807 306 59 including include VERB bam-1807 306 60 protein protein NOUN bam-1807 306 61 kinase kinase PROPN bam-1807 306 62 b b PROPN bam-1807 306 63 / / SYM bam-1807 306 64 akt akt PROPN bam-1807 306 65 and and CCONJ bam-1807 306 66 downstream downstream ADJ bam-1807 306 67 targets target NOUN bam-1807 306 68 p70 p70 NOUN bam-1807 306 69 ribosomal ribosomal NOUN bam-1807 306 70 s6 s6 PROPN bam-1807 306 71 kinase kinase PROPN bam-1807 306 72 and and CCONJ bam-1807 306 73 4e 4e NOUN bam-1807 306 74 binding bind VERB bam-1807 306 75 protein protein NOUN bam-1807 306 76 1 1 NUM bam-1807 307 1 [ [ X bam-1807 307 2 31 31 NUM bam-1807 307 3 ] ] PUNCT bam-1807 307 4 . . PUNCT bam-1807 308 1 10 10 NUM bam-1807 308 2 . . X bam-1807 308 3 muscle muscle NOUN bam-1807 308 4 - - PUNCT bam-1807 308 5 to to ADP bam-1807 308 6 - - PUNCT bam-1807 308 7 body body NOUN bam-1807 308 8 signals signal NOUN bam-1807 308 9 , , PUNCT bam-1807 308 10 hormones hormone NOUN bam-1807 308 11 , , PUNCT bam-1807 308 12 aging age VERB bam-1807 308 13 from from ADP bam-1807 308 14 the the DET bam-1807 308 15 initial initial ADJ bam-1807 308 16 concept concept NOUN bam-1807 308 17 that that SCONJ bam-1807 308 18 skeletal skeletal ADJ bam-1807 308 19 muscle muscle NOUN bam-1807 308 20 is be AUX bam-1807 308 21 the the DET bam-1807 308 22 mere mere ADJ bam-1807 308 23 object object NOUN bam-1807 308 24 of of ADP bam-1807 308 25 regulatory regulatory ADJ bam-1807 308 26 clues clue NOUN bam-1807 308 27 , , PUNCT bam-1807 308 28 finalized finalize VERB bam-1807 308 29 to to ADP bam-1807 308 30 its its PRON bam-1807 308 31 efficient efficient ADJ bam-1807 308 32 adaptation adaptation NOUN bam-1807 308 33 to to ADP bam-1807 308 34 the the DET bam-1807 308 35 changing change VERB bam-1807 308 36 needs need NOUN bam-1807 308 37 of of ADP bam-1807 308 38 the the DET bam-1807 308 39 body body NOUN bam-1807 308 40 , , PUNCT bam-1807 308 41 the the DET bam-1807 308 42 scientific scientific ADJ bam-1807 308 43 community community NOUN bam-1807 308 44 is be AUX bam-1807 308 45 now now ADV bam-1807 308 46 realizing realize VERB bam-1807 308 47 that that SCONJ bam-1807 308 48 the the DET bam-1807 308 49 muscle muscle NOUN bam-1807 308 50 has have VERB bam-1807 308 51 a a DET bam-1807 308 52 central central ADJ bam-1807 308 53 role role NOUN bam-1807 308 54 in in ADP bam-1807 308 55 regulating regulate VERB bam-1807 308 56 its its PRON bam-1807 308 57 own own ADJ bam-1807 308 58 metabolism metabolism NOUN bam-1807 308 59 and and CCONJ bam-1807 308 60 that that SCONJ bam-1807 308 61 it it PRON bam-1807 308 62 is be AUX bam-1807 308 63 constantly constantly ADV bam-1807 308 64 exchanging exchange VERB bam-1807 308 65 homeostatic homeostatic ADJ bam-1807 308 66 information information NOUN bam-1807 308 67 with with ADP bam-1807 308 68 the the DET bam-1807 308 69 rest rest NOUN bam-1807 308 70 of of ADP bam-1807 308 71 the the DET bam-1807 308 72 body body NOUN bam-1807 308 73 . . PUNCT bam-1807 309 1 central central ADJ bam-1807 309 2 to to ADP bam-1807 309 3 this this DET bam-1807 309 4 function function NOUN bam-1807 309 5 is be AUX bam-1807 309 6 the the DET bam-1807 309 7 production production NOUN bam-1807 309 8 of of ADP bam-1807 309 9 several several ADJ bam-1807 309 10 biologically biologically ADV bam-1807 309 11 active active ADJ bam-1807 309 12 substances substance NOUN bam-1807 309 13 , , PUNCT bam-1807 309 14 including include VERB bam-1807 309 15 myokines myokine NOUN bam-1807 309 16 , , PUNCT bam-1807 309 17 which which PRON bam-1807 309 18 participate participate VERB bam-1807 309 19 in in ADP bam-1807 309 20 cell cell NOUN bam-1807 309 21 to to ADP bam-1807 309 22 - - PUNCT bam-1807 309 23 cell cell NOUN bam-1807 309 24 and and CCONJ bam-1807 309 25 organ organ NOUN bam-1807 309 26 - - PUNCT bam-1807 309 27 to to ADP bam-1807 309 28 - - PUNCT bam-1807 309 29 organ organ NOUN bam-1807 309 30 crosstalk crosstalk NOUN bam-1807 309 31 [ [ X bam-1807 309 32 99 99 NUM bam-1807 309 33 ] ] PUNCT bam-1807 309 34 . . PUNCT bam-1807 310 1 in in ADP bam-1807 310 2 the the DET bam-1807 310 3 regulation regulation NOUN bam-1807 310 4 of of ADP bam-1807 310 5 metabolism metabolism NOUN bam-1807 310 6 , , PUNCT bam-1807 310 7 one one NUM bam-1807 310 8 of of ADP bam-1807 310 9 the the DET bam-1807 310 10 most most ADV bam-1807 310 11 important important ADJ bam-1807 310 12 organ organ NOUN bam-1807 310 13 - - PUNCT bam-1807 310 14 to to ADP bam-1807 310 15 - - PUNCT bam-1807 310 16 organ organ NOUN bam-1807 310 17 relationships relationship NOUN bam-1807 310 18 is be AUX bam-1807 310 19 that that SCONJ bam-1807 310 20 between between ADP bam-1807 310 21 skeletal skeletal ADJ bam-1807 310 22 muscle muscle NOUN bam-1807 310 23 and and CCONJ bam-1807 310 24 adipose adipose ADJ bam-1807 310 25 tissue tissue NOUN bam-1807 310 26 . . PUNCT bam-1807 311 1 in in ADP bam-1807 311 2 fact fact NOUN bam-1807 311 3 , , PUNCT bam-1807 311 4 metabolic metabolic NOUN bam-1807 311 5 changes change NOUN bam-1807 311 6 induced induce VERB bam-1807 311 7 by by ADP bam-1807 311 8 physical physical ADJ bam-1807 311 9 activity activity NOUN bam-1807 311 10 contribute contribute VERB bam-1807 311 11 to to PART bam-1807 311 12 restore restore VERB bam-1807 311 13 a a DET bam-1807 311 14 correct correct ADJ bam-1807 311 15 caloric caloric NOUN bam-1807 311 16 equilibrium equilibrium NOUN bam-1807 311 17 and and CCONJ bam-1807 311 18 to to PART bam-1807 311 19 counteract counteract VERB bam-1807 311 20 the the DET bam-1807 311 21 building building NOUN bam-1807 311 22 up up ADP bam-1807 311 23 of of ADP bam-1807 311 24 fat fat ADJ bam-1807 311 25 mass mass NOUN bam-1807 311 26 . . PUNCT bam-1807 312 1 it it PRON bam-1807 312 2 has have AUX bam-1807 312 3 been be AUX bam-1807 312 4 underlined underline VERB bam-1807 312 5 that that SCONJ bam-1807 312 6 dynamic dynamic ADJ bam-1807 312 7 changes change NOUN bam-1807 312 8 in in ADP bam-1807 312 9 adipose adipose ADJ bam-1807 312 10 tissue tissue NOUN bam-1807 312 11 and and CCONJ bam-1807 312 12 skeletal skeletal ADJ bam-1807 312 13 muscle muscle NOUN bam-1807 312 14 metabolic metabolic NOUN bam-1807 312 15 and and CCONJ bam-1807 312 16 endocrine endocrine ADJ bam-1807 312 17 phenotype phenotype NOUN bam-1807 312 18 contribute contribute VERB bam-1807 312 19 to to PART bam-1807 312 20 determine determine VERB bam-1807 312 21 the the DET bam-1807 312 22 difference difference NOUN bam-1807 312 23 between between ADP bam-1807 312 24 metabolic metabolic NOUN bam-1807 312 25 health health NOUN bam-1807 312 26 and and CCONJ bam-1807 312 27 disease disease NOUN bam-1807 312 28 [ [ X bam-1807 312 29 116 116 X bam-1807 312 30 ] ] PUNCT bam-1807 312 31 . . PUNCT bam-1807 313 1 it it PRON bam-1807 313 2 is be AUX bam-1807 313 3 also also ADV bam-1807 313 4 well well ADV bam-1807 313 5 known know VERB bam-1807 313 6 that that SCONJ bam-1807 313 7 physical physical ADJ bam-1807 313 8 exercise exercise NOUN bam-1807 313 9 is be AUX bam-1807 313 10 able able ADJ bam-1807 313 11 to to PART bam-1807 313 12 improve improve VERB bam-1807 313 13 glucose glucose NOUN bam-1807 313 14 metabolism metabolism NOUN bam-1807 313 15 and and CCONJ bam-1807 313 16 to to PART bam-1807 313 17 prevent prevent VERB bam-1807 313 18 the the DET bam-1807 313 19 onset onset NOUN bam-1807 313 20 of of ADP bam-1807 313 21 insulin insulin NOUN bam-1807 313 22 resistance resistance NOUN bam-1807 314 1 [ [ X bam-1807 314 2 49 49 NUM bam-1807 314 3 ] ] PUNCT bam-1807 314 4 ; ; PUNCT bam-1807 314 5 in in ADP bam-1807 314 6 type type NOUN bam-1807 314 7 2 2 NUM bam-1807 314 8 diabetes diabetes NOUN bam-1807 314 9 patients patient NOUN bam-1807 314 10 , , PUNCT bam-1807 314 11 endurance endurance NOUN bam-1807 314 12 training training NOUN bam-1807 314 13 has have AUX bam-1807 314 14 proven prove VERB bam-1807 314 15 even even ADV bam-1807 314 16 more more ADV bam-1807 314 17 effective effective ADJ bam-1807 314 18 than than ADP bam-1807 314 19 the the DET bam-1807 314 20 most most ADV bam-1807 314 21 widely widely ADV bam-1807 314 22 used use VERB bam-1807 314 23 anti anti ADJ bam-1807 314 24 - - ADJ bam-1807 314 25 diabetic diabetic ADJ bam-1807 314 26 drug drug NOUN bam-1807 314 27 , , PUNCT bam-1807 314 28 metformin metformin NOUN bam-1807 314 29 , , PUNCT bam-1807 314 30 in in ADP bam-1807 314 31 controlling control VERB bam-1807 314 32 glucose glucose NOUN bam-1807 314 33 metabolism metabolism NOUN bam-1807 315 1 [ [ X bam-1807 315 2 52 52 NUM bam-1807 315 3 ] ] PUNCT bam-1807 315 4 . . PUNCT bam-1807 316 1 interestingly interestingly ADV bam-1807 316 2 , , PUNCT bam-1807 316 3 the the DET bam-1807 316 4 widely widely ADV bam-1807 316 5 held hold VERB bam-1807 316 6 opinion opinion NOUN bam-1807 316 7 that that SCONJ bam-1807 316 8 such such ADJ bam-1807 316 9 effects effect NOUN bam-1807 316 10 on on ADP bam-1807 316 11 the the DET bam-1807 316 12 control control NOUN bam-1807 316 13 of of ADP bam-1807 316 14 body body NOUN bam-1807 316 15 fat fat ADJ bam-1807 316 16 mass mass NOUN bam-1807 316 17 and and CCONJ bam-1807 316 18 of of ADP bam-1807 316 19 glucose glucose NOUN bam-1807 316 20 metabolism metabolism NOUN bam-1807 316 21 are be AUX bam-1807 316 22 related relate VERB bam-1807 316 23 to to ADP bam-1807 316 24 the the DET bam-1807 316 25 effect effect NOUN bam-1807 316 26 of of ADP bam-1807 316 27 physical physical ADJ bam-1807 316 28 exercise exercise NOUN bam-1807 316 29 on on ADP bam-1807 316 30 the the DET bam-1807 316 31 energy energy NOUN bam-1807 316 32 balance balance NOUN bam-1807 316 33 or or CCONJ bam-1807 316 34 , , PUNCT bam-1807 316 35 rather rather ADV bam-1807 316 36 , , PUNCT bam-1807 316 37 to to ADP bam-1807 316 38 the the DET bam-1807 316 39 energy energy NOUN bam-1807 316 40 expenditure expenditure NOUN bam-1807 316 41 consequent consequent NOUN bam-1807 316 42 to to ADP bam-1807 316 43 physical physical ADJ bam-1807 316 44 activity activity NOUN bam-1807 316 45 , , PUNCT bam-1807 316 46 has have AUX bam-1807 316 47 been be AUX bam-1807 316 48 attenuated attenuate VERB bam-1807 316 49 by by ADP bam-1807 316 50 a a DET bam-1807 316 51 recent recent ADJ bam-1807 316 52 paper paper NOUN bam-1807 316 53 showing show VERB bam-1807 316 54 that that SCONJ bam-1807 316 55 intake intake NOUN bam-1807 316 56 of of ADP bam-1807 316 57 antioxidants antioxidant NOUN bam-1807 316 58 prevented prevent VERB bam-1807 316 59 the the DET bam-1807 316 60 exercise exercise NOUN bam-1807 316 61 - - PUNCT bam-1807 316 62 mediated mediate VERB bam-1807 316 63 increase increase NOUN bam-1807 316 64 in in ADP bam-1807 316 65 insulin insulin NOUN bam-1807 316 66 sensitivity sensitivity NOUN bam-1807 316 67 , , PUNCT bam-1807 316 68 thus thus ADV bam-1807 316 69 demonstrating demonstrate VERB bam-1807 316 70 that that PRON bam-1807 316 71 exercisegenerated exercisegenerate VERB bam-1807 316 72 ros ros PROPN bam-1807 316 73 have have VERB bam-1807 316 74 a a DET bam-1807 316 75 role role NOUN bam-1807 316 76 in in ADP bam-1807 316 77 the the DET bam-1807 316 78 beneficial beneficial ADJ bam-1807 316 79 effects effect NOUN bam-1807 316 80 of of ADP bam-1807 316 81 physical physical ADJ bam-1807 316 82 activity activity NOUN bam-1807 317 1 [ [ X bam-1807 317 2 90 90 NUM bam-1807 317 3 ] ] PUNCT bam-1807 317 4 . . PUNCT bam-1807 318 1 another another DET bam-1807 318 2 emerging emerge VERB bam-1807 318 3 role role NOUN bam-1807 318 4 of of ADP bam-1807 318 5 resistance resistance NOUN bam-1807 318 6 training training NOUN bam-1807 318 7 in in ADP bam-1807 318 8 counteracting counteract VERB bam-1807 318 9 the the DET bam-1807 318 10 negative negative ADJ bam-1807 318 11 effects effect NOUN bam-1807 318 12 of of ADP bam-1807 318 13 type type NOUN bam-1807 318 14 2 2 NUM bam-1807 318 15 diabete diabete NOUN bam-1807 318 16 has have AUX bam-1807 318 17 been be AUX bam-1807 318 18 underlined underline VERB bam-1807 318 19 by by ADP bam-1807 318 20 dipenta dipenta NOUN bam-1807 318 21 et et PROPN bam-1807 318 22 al al PROPN bam-1807 318 23 . . PUNCT bam-1807 319 1 [ [ X bam-1807 319 2 22 22 NUM bam-1807 319 3 ] ] PUNCT bam-1807 319 4 , , PUNCT bam-1807 319 5 who who PRON bam-1807 319 6 took take VERB bam-1807 319 7 into into ADP bam-1807 319 8 consideration consideration NOUN bam-1807 319 9 the the DET bam-1807 319 10 immunomodulatory immunomodulatory ADJ bam-1807 319 11 effects effect NOUN bam-1807 319 12 of of ADP bam-1807 319 13 exercise exercise NOUN bam-1807 319 14 and and CCONJ bam-1807 319 15 concluded conclude VERB bam-1807 319 16 that that SCONJ bam-1807 319 17 exercise exercise NOUN bam-1807 319 18 training training NOUN bam-1807 319 19 is be AUX bam-1807 319 20 able able ADJ bam-1807 319 21 to to PART bam-1807 319 22 modulate modulate VERB bam-1807 319 23 the the DET bam-1807 319 24 pro pro ADJ bam-1807 319 25 - - ADJ bam-1807 319 26 inflammatory inflammatory ADJ bam-1807 319 27 parameters parameter NOUN bam-1807 319 28 associated associate VERB bam-1807 319 29 with with ADP bam-1807 319 30 the the DET bam-1807 319 31 disease disease NOUN bam-1807 319 32 . . PUNCT bam-1807 320 1 energy energy NOUN bam-1807 320 2 metabolism metabolism NOUN bam-1807 320 3 and and CCONJ bam-1807 320 4 physical physical ADJ bam-1807 320 5 activity activity NOUN bam-1807 320 6 have have VERB bam-1807 320 7 also also ADV bam-1807 320 8 an an DET bam-1807 320 9 important important ADJ bam-1807 320 10 role role NOUN bam-1807 320 11 in in ADP bam-1807 320 12 the the DET bam-1807 320 13 maintenance maintenance NOUN bam-1807 320 14 of of ADP bam-1807 320 15 a a DET bam-1807 320 16 healthy healthy ADJ bam-1807 320 17 heart heart NOUN bam-1807 320 18 , , PUNCT bam-1807 320 19 and and CCONJ bam-1807 320 20 , , PUNCT bam-1807 320 21 in in ADP bam-1807 320 22 particular particular ADJ bam-1807 320 23 , , PUNCT bam-1807 320 24 it it PRON bam-1807 320 25 has have AUX bam-1807 320 26 been be AUX bam-1807 320 27 shown show VERB bam-1807 320 28 that that SCONJ bam-1807 320 29 endurance endurance NOUN bam-1807 320 30 training training NOUN bam-1807 320 31 decreases decrease VERB bam-1807 320 32 the the DET bam-1807 320 33 risk risk NOUN bam-1807 320 34 for for ADP bam-1807 320 35 heart heart NOUN bam-1807 320 36 failure failure NOUN bam-1807 320 37 and and CCONJ bam-1807 320 38 is be AUX bam-1807 320 39 beneficial beneficial ADJ bam-1807 320 40 for for ADP bam-1807 320 41 heart heart NOUN bam-1807 320 42 failure failure NOUN bam-1807 320 43 patients patient NOUN bam-1807 320 44 . . PUNCT bam-1807 321 1 this this DET bam-1807 321 2 issue issue NOUN bam-1807 321 3 has have AUX bam-1807 321 4 been be AUX bam-1807 321 5 recently recently ADV bam-1807 321 6 reviewed review VERB bam-1807 321 7 [ [ PUNCT bam-1807 321 8 117 117 NUM bam-1807 321 9 ] ] PUNCT bam-1807 321 10 . . PUNCT bam-1807 322 1 aging age VERB bam-1807 322 2 deeply deeply ADV bam-1807 322 3 affects affect VERB bam-1807 322 4 the the DET bam-1807 322 5 skeletal skeletal ADJ bam-1807 322 6 muscle muscle NOUN bam-1807 322 7 . . PUNCT bam-1807 323 1 progressive progressive ADJ bam-1807 323 2 loss loss NOUN bam-1807 323 3 of of ADP bam-1807 323 4 muscle muscle NOUN bam-1807 323 5 mass mass PROPN bam-1807 323 6 ( ( PUNCT bam-1807 323 7 sarcopenia sarcopenia PROPN bam-1807 323 8 ) ) PUNCT bam-1807 323 9 is be AUX bam-1807 323 10 one one NUM bam-1807 323 11 of of ADP bam-1807 323 12 the the DET bam-1807 323 13 most most ADV bam-1807 323 14 striking striking ADJ bam-1807 323 15 phenomena phenomenon NOUN bam-1807 323 16 of of ADP bam-1807 323 17 aging aging NOUN bam-1807 323 18 . . PUNCT bam-1807 324 1 it it PRON bam-1807 324 2 is be AUX bam-1807 324 3 characterized characterize VERB bam-1807 324 4 by by ADP bam-1807 324 5 a a DET bam-1807 324 6 deterioration deterioration NOUN bam-1807 324 7 of of ADP bam-1807 324 8 muscle muscle NOUN bam-1807 324 9 quantity quantity NOUN bam-1807 324 10 and and CCONJ bam-1807 324 11 quality quality NOUN bam-1807 324 12 , , PUNCT bam-1807 324 13 leading lead VERB bam-1807 324 14 to to ADP bam-1807 324 15 a a DET bam-1807 324 16 gradual gradual ADJ bam-1807 324 17 slowing slowing NOUN bam-1807 324 18 of of ADP bam-1807 324 19 movement movement NOUN bam-1807 324 20 and and CCONJ bam-1807 324 21 a a DET bam-1807 324 22 decline decline NOUN bam-1807 324 23 in in ADP bam-1807 324 24 the the DET bam-1807 324 25 exercised exercise VERB bam-1807 324 26 skeletal skeletal ADJ bam-1807 324 27 muscle muscle NOUN bam-1807 324 28 european european PROPN bam-1807 324 29 journal journal PROPN bam-1807 324 30 translational translational ADJ bam-1807 324 31 myology myology NOUN bam-1807 324 32 myology myology NOUN bam-1807 324 33 reviews review VERB bam-1807 324 34 20 20 NUM bam-1807 324 35 ( ( PUNCT bam-1807 324 36 3 3 NUM bam-1807 324 37 ): ): PUNCT bam-1807 324 38 105 105 NUM bam-1807 324 39 - - SYM bam-1807 324 40 120 120 NUM bam-1807 324 41 , , PUNCT bam-1807 324 42 2010 2010 NUM bam-1807 324 43 115 115 NUM bam-1807 324 44 strength strength NOUN bam-1807 324 45 and and CCONJ bam-1807 324 46 power power NOUN bam-1807 324 47 . . PUNCT bam-1807 325 1 it it PRON bam-1807 325 2 is be AUX bam-1807 325 3 now now ADV bam-1807 325 4 realized realize VERB bam-1807 325 5 that that SCONJ bam-1807 325 6 metabolic metabolic NOUN bam-1807 325 7 adaptations adaptation NOUN bam-1807 325 8 leading lead VERB bam-1807 325 9 to to ADP bam-1807 325 10 sarcopenia sarcopenia NOUN bam-1807 325 11 , , PUNCT bam-1807 325 12 cachexia cachexia NOUN bam-1807 325 13 and and CCONJ bam-1807 325 14 atrophy atrophy NOUN bam-1807 325 15 are be AUX bam-1807 325 16 only only ADV bam-1807 325 17 partially partially ADV bam-1807 325 18 overlapping overlap VERB bam-1807 325 19 and and CCONJ bam-1807 325 20 result result VERB bam-1807 325 21 from from ADP bam-1807 325 22 different different ADJ bam-1807 325 23 gene gene NOUN bam-1807 325 24 expression expression NOUN bam-1807 325 25 and and CCONJ bam-1807 325 26 signaling signal VERB bam-1807 325 27 cascades cascade NOUN bam-1807 325 28 . . PUNCT bam-1807 326 1 in in ADP bam-1807 326 2 sarcopenia sarcopenia PROPN bam-1807 326 3 , , PUNCT bam-1807 326 4 the the DET bam-1807 326 5 major major ADJ bam-1807 326 6 changes change NOUN bam-1807 326 7 involve involve VERB bam-1807 326 8 fiber fiber NOUN bam-1807 326 9 size size NOUN bam-1807 326 10 , , PUNCT bam-1807 326 11 mitochondrial mitochondrial ADJ bam-1807 326 12 homeostatis homeostatis NOUN bam-1807 326 13 and and CCONJ bam-1807 326 14 apoptosis apoptosis NOUN bam-1807 326 15 and and CCONJ bam-1807 326 16 are be AUX bam-1807 326 17 related relate VERB bam-1807 326 18 to to ADP bam-1807 326 19 a a DET bam-1807 326 20 disruption disruption NOUN bam-1807 326 21 of of ADP bam-1807 326 22 akt akt PROPN bam-1807 326 23 - - PUNCT bam-1807 326 24 mtor mtor PROPN bam-1807 326 25 and and CCONJ bam-1807 326 26 rhoa rhoa PROPN bam-1807 326 27 - - PUNCT bam-1807 326 28 srf srf NOUN bam-1807 326 29 signaling signal VERB bam-1807 326 30 but but CCONJ bam-1807 326 31 not not PART bam-1807 326 32 atrogin-1 atrogin-1 NUM bam-1807 326 33 or or CCONJ bam-1807 326 34 murf1 murf1 NOUN bam-1807 326 35 . . PUNCT bam-1807 327 1 a a DET bam-1807 327 2 recent recent ADJ bam-1807 327 3 review review NOUN bam-1807 327 4 suggests suggest VERB bam-1807 327 5 that that SCONJ bam-1807 327 6 “ " PUNCT bam-1807 327 7 resistance resistance NOUN bam-1807 327 8 training training NOUN bam-1807 327 9 in in ADP bam-1807 327 10 combination combination NOUN bam-1807 327 11 with with ADP bam-1807 327 12 amino amino NOUN bam-1807 327 13 acid acid NOUN bam-1807 327 14 - - PUNCT bam-1807 327 15 containing contain VERB bam-1807 327 16 nutrition nutrition NOUN bam-1807 327 17 would would AUX bam-1807 327 18 be be AUX bam-1807 327 19 the the DET bam-1807 327 20 best good ADJ bam-1807 327 21 candidate candidate NOUN bam-1807 327 22 to to PART bam-1807 327 23 attenuate attenuate VERB bam-1807 327 24 , , PUNCT bam-1807 327 25 prevent prevent VERB bam-1807 327 26 , , PUNCT bam-1807 327 27 or or CCONJ bam-1807 327 28 ultimately ultimately ADV bam-1807 327 29 reverse reverse VERB bam-1807 327 30 age age NOUN bam-1807 327 31 - - PUNCT bam-1807 327 32 related relate VERB bam-1807 327 33 muscle muscle NOUN bam-1807 327 34 wasting waste VERB bam-1807 327 35 and and CCONJ bam-1807 327 36 weakness weakness NOUN bam-1807 327 37 ” " PUNCT bam-1807 327 38 [ [ X bam-1807 327 39 94 94 NUM bam-1807 327 40 ] ] PUNCT bam-1807 327 41 . . PUNCT bam-1807 328 1 within within ADP bam-1807 328 2 20 20 NUM bam-1807 328 3 years year NOUN bam-1807 328 4 , , PUNCT bam-1807 328 5 more more ADJ bam-1807 328 6 than than ADP bam-1807 328 7 20 20 NUM bam-1807 328 8 % % NOUN bam-1807 328 9 of of ADP bam-1807 328 10 the the DET bam-1807 328 11 united united PROPN bam-1807 328 12 states states PROPN bam-1807 328 13 , , PUNCT bam-1807 328 14 china china PROPN bam-1807 328 15 , , PUNCT bam-1807 328 16 japan japan PROPN bam-1807 328 17 , , PUNCT bam-1807 328 18 and and CCONJ bam-1807 328 19 europe europe PROPN bam-1807 328 20 population population NOUN bam-1807 328 21 will will AUX bam-1807 328 22 be be AUX bam-1807 328 23 older old ADJ bam-1807 328 24 than than ADP bam-1807 328 25 65 65 NUM bam-1807 328 26 years year NOUN bam-1807 328 27 and and CCONJ bam-1807 328 28 will will AUX bam-1807 328 29 presumably presumably ADV bam-1807 328 30 suffer suffer VERB bam-1807 328 31 of of ADP bam-1807 328 32 age age NOUN bam-1807 328 33 - - PUNCT bam-1807 328 34 related relate VERB bam-1807 328 35 diseases disease NOUN bam-1807 328 36 and and CCONJ bam-1807 328 37 disabilities disability NOUN bam-1807 328 38 : : PUNCT bam-1807 328 39 metabolic metabolic NOUN bam-1807 328 40 syndrome syndrome NOUN bam-1807 328 41 , , PUNCT bam-1807 328 42 cognitive cognitive ADJ bam-1807 328 43 impairment impairment NOUN bam-1807 328 44 , , PUNCT bam-1807 328 45 and and CCONJ bam-1807 328 46 physical physical ADJ bam-1807 328 47 weakness weakness NOUN bam-1807 328 48 . . PUNCT bam-1807 329 1 as as ADP bam-1807 329 2 a a DET bam-1807 329 3 concluding conclude VERB bam-1807 329 4 remark remark NOUN bam-1807 329 5 of of ADP bam-1807 329 6 this this DET bam-1807 329 7 review review NOUN bam-1807 329 8 we we PRON bam-1807 329 9 wish wish VERB bam-1807 329 10 to to PART bam-1807 329 11 underline underline VERB bam-1807 329 12 the the DET bam-1807 329 13 ability ability NOUN bam-1807 329 14 of of ADP bam-1807 329 15 exercise exercise NOUN bam-1807 329 16 to to PART bam-1807 329 17 offset offset VERB bam-1807 329 18 the the DET bam-1807 329 19 age age NOUN bam-1807 329 20 - - PUNCT bam-1807 329 21 related relate VERB bam-1807 329 22 decline decline NOUN bam-1807 329 23 in in ADP bam-1807 329 24 both both CCONJ bam-1807 329 25 physical physical ADJ bam-1807 329 26 and and CCONJ bam-1807 329 27 mental mental ADJ bam-1807 329 28 fitness fitness NOUN bam-1807 329 29 ( ( PUNCT bam-1807 329 30 see see VERB bam-1807 329 31 , , PUNCT bam-1807 329 32 for for ADP bam-1807 329 33 instance instance NOUN bam-1807 329 34 , , PUNCT bam-1807 329 35 [ [ X bam-1807 329 36 110 110 NUM bam-1807 329 37 ] ] PUNCT bam-1807 329 38 and and CCONJ bam-1807 329 39 to to PART bam-1807 329 40 significantly significantly ADV bam-1807 329 41 contribute contribute VERB bam-1807 329 42 to to ADP bam-1807 329 43 the the DET bam-1807 329 44 solution solution NOUN bam-1807 329 45 of of ADP bam-1807 329 46 many many ADJ bam-1807 329 47 important important ADJ bam-1807 329 48 public public ADJ bam-1807 329 49 health health NOUN bam-1807 329 50 problems problem NOUN bam-1807 329 51 . . PUNCT bam-1807 330 1 acknowledgements acknowledgement NOUN bam-1807 330 2 authors author NOUN bam-1807 330 3 acknowledge acknowledge VERB bam-1807 330 4 the the DET bam-1807 330 5 contribution contribution NOUN bam-1807 330 6 of of ADP bam-1807 330 7 the the DET bam-1807 330 8 italian italian ADJ bam-1807 330 9 ministry ministry PROPN bam-1807 330 10 of of ADP bam-1807 330 11 university university PROPN bam-1807 330 12 and and CCONJ bam-1807 330 13 research research NOUN bam-1807 330 14 ( ( PUNCT bam-1807 330 15 grant grant PROPN bam-1807 330 16 prin prin PROPN bam-1807 330 17 2007 2007 NUM bam-1807 330 18 protocol protocol NOUN bam-1807 330 19 number number NOUN bam-1807 330 20 2007y4wf3 2007y4wf3 NUM bam-1807 330 21 t t PROPN bam-1807 330 22 ) ) PUNCT bam-1807 330 23 , , PUNCT bam-1807 330 24 italy italy PROPN bam-1807 330 25 and and CCONJ bam-1807 330 26 of of ADP bam-1807 330 27 “ " PUNCT bam-1807 330 28 don don PROPN bam-1807 330 29 gnocchi gnocchi PROPN bam-1807 330 30 foundation foundation PROPN bam-1807 330 31 ” " PUNCT bam-1807 330 32 , , PUNCT bam-1807 330 33 milan milan PROPN bam-1807 330 34 , , PUNCT bam-1807 330 35 italy italy PROPN bam-1807 330 36 ( ( PUNCT bam-1807 330 37 grant grant VERB bam-1807 330 38 “ " PUNCT bam-1807 330 39 current current ADJ bam-1807 330 40 research research NOUN bam-1807 330 41 ” " PUNCT bam-1807 330 42 ) ) PUNCT bam-1807 330 43 . . PUNCT bam-1807 331 1 corresponding correspond VERB bam-1807 331 2 author author NOUN bam-1807 331 3 prof prof PROPN bam-1807 331 4 . . PROPN bam-1807 331 5 marina marina PROPN bam-1807 331 6 marini marini PROPN bam-1807 331 7 , , PUNCT bam-1807 331 8 department department NOUN bam-1807 331 9 of of ADP bam-1807 331 10 histology histology NOUN bam-1807 331 11 , , PUNCT bam-1807 331 12 embryology embryology NOUN bam-1807 331 13 , , PUNCT bam-1807 331 14 and and CCONJ bam-1807 331 15 applied apply VERB bam-1807 331 16 biology biology NOUN bam-1807 331 17 , , PUNCT bam-1807 331 18 university university NOUN bam-1807 331 19 of of ADP bam-1807 331 20 bologna bologna NOUN bam-1807 331 21 , , PUNCT bam-1807 331 22 via via ADP bam-1807 331 23 belmeloro,8 belmeloro,8 NOUN bam-1807 331 24 , , PUNCT bam-1807 331 25 i-40126 i-40126 ADJ bam-1807 331 26 bologna bologna NOUN bam-1807 331 27 , , PUNCT bam-1807 331 28 italy italy PROPN bam-1807 331 29 phone phone NOUN bam-1807 331 30 : : PUNCT bam-1807 331 31 +39 +39 PROPN bam-1807 331 32 051 051 NUM bam-1807 331 33 2094116 2094116 NUM bam-1807 331 34 ; ; PUNCT bam-1807 331 35 fax fax PROPN bam-1807 331 36 +39 +39 PROPN bam-1807 331 37 051 051 NUM bam-1807 331 38 2094110 2094110 NUM bam-1807 331 39 ; ; PUNCT bam-1807 331 40 email email NOUN bam-1807 331 41 : : PUNCT bam-1807 331 42 marina.marini@unibo.it marina.marini@unibo.it PROPN bam-1807 331 43 references reference NOUN bam-1807 331 44 [ [ X bam-1807 331 45 1 1 NUM bam-1807 331 46 ] ] PUNCT bam-1807 331 47 adhihetty adhihetty PROPN bam-1807 331 48 pj pj PROPN bam-1807 331 49 , , PUNCT bam-1807 331 50 ljubicic ljubicic PROPN bam-1807 331 51 v v ADP bam-1807 331 52 , , PUNCT bam-1807 331 53 hood hood NOUN bam-1807 331 54 da da NOUN bam-1807 331 55 . . PUNCT bam-1807 331 56 effect effect NOUN bam-1807 331 57 of of ADP bam-1807 331 58 chronic chronic ADJ bam-1807 331 59 contractile contractile NOUN bam-1807 331 60 activity activity NOUN bam-1807 331 61 on on ADP bam-1807 331 62 ss ss NOUN bam-1807 331 63 and and CCONJ bam-1807 331 64 imf imf PROPN bam-1807 331 65 mitochondrial mitochondrial ADJ bam-1807 331 66 apoptotic apoptotic ADJ bam-1807 331 67 susceptibility susceptibility NOUN bam-1807 331 68 in in ADP bam-1807 331 69 skeletal skeletal ADJ bam-1807 331 70 muscle muscle NOUN bam-1807 331 71 am am NOUN bam-1807 331 72 . . PUNCT bam-1807 332 1 j. j. PROPN bam-1807 332 2 physiol physiol PROPN bam-1807 332 3 . . PUNCT bam-1807 333 1 endocrinol endocrinol NOUN bam-1807 333 2 . . PUNCT bam-1807 334 1 metab metab PROPN bam-1807 334 2 . . PUNCT bam-1807 335 1 2007 2007 NUM bam-1807 335 2 ; ; PUNCT bam-1807 335 3 292 292 NUM bam-1807 335 4 : : PUNCT bam-1807 335 5 e748 e748 NUM bam-1807 335 6 - - PUNCT bam-1807 335 7 e755 e755 PROPN bam-1807 335 8 . . PUNCT bam-1807 336 1 [ [ X bam-1807 336 2 2 2 X bam-1807 336 3 ] ] PUNCT bam-1807 336 4 ameln ameln NOUN bam-1807 336 5 h h PROPN bam-1807 336 6 , , PUNCT bam-1807 336 7 gustafsson gustafsson PROPN bam-1807 336 8 t t PROPN bam-1807 336 9 , , PUNCT bam-1807 336 10 sundberg sundberg PROPN bam-1807 336 11 cj cj PROPN bam-1807 336 12 , , PUNCT bam-1807 336 13 okamoto okamoto PROPN bam-1807 336 14 k k PROPN bam-1807 336 15 , , PUNCT bam-1807 336 16 jansson jansson PROPN bam-1807 336 17 e e PROPN bam-1807 336 18 , , PUNCT bam-1807 336 19 poellinger poellinger NOUN bam-1807 336 20 l l NOUN bam-1807 336 21 , , PUNCT bam-1807 336 22 makino makino PROPN bam-1807 336 23 y. y. PROPN bam-1807 336 24 physiological physiological ADJ bam-1807 336 25 activation activation NOUN bam-1807 336 26 of of ADP bam-1807 336 27 hypoxia hypoxia NOUN bam-1807 336 28 inducible inducible ADJ bam-1807 336 29 factor-1 factor-1 X bam-1807 336 30 in in ADP bam-1807 336 31 human human ADJ bam-1807 336 32 skeletal skeletal ADJ bam-1807 336 33 muscle muscle NOUN bam-1807 336 34 . . PUNCT bam-1807 337 1 faseb faseb PROPN bam-1807 337 2 j. j. PROPN bam-1807 337 3 2005 2005 NUM bam-1807 337 4 ; ; PUNCT bam-1807 337 5 19:1009–1011 19:1009–1011 NUM bam-1807 337 6 . . PUNCT bam-1807 338 1 [ [ X bam-1807 338 2 3 3 NUM bam-1807 338 3 ] ] X bam-1807 338 4 andersen andersen PROPN bam-1807 338 5 jl jl PROPN bam-1807 338 6 , , PUNCT bam-1807 338 7 schjerling schjerle VERB bam-1807 338 8 p p PRON bam-1807 338 9 , , PUNCT bam-1807 338 10 saltin saltin PROPN bam-1807 338 11 b. b. PROPN bam-1807 338 12 muscle muscle PROPN bam-1807 338 13 , , PUNCT bam-1807 338 14 genes gene NOUN bam-1807 338 15 and and CCONJ bam-1807 338 16 athletic athletic ADJ bam-1807 338 17 performance performance NOUN bam-1807 338 18 . . PUNCT bam-1807 339 1 sci sci PROPN bam-1807 339 2 . . PROPN bam-1807 339 3 am be AUX bam-1807 339 4 . . PROPN bam-1807 340 1 2000 2000 NUM bam-1807 340 2 ; ; PUNCT bam-1807 340 3 283:48 283:48 PROPN bam-1807 340 4 - - SYM bam-1807 340 5 55 55 NUM bam-1807 340 6 . . PUNCT bam-1807 341 1 [ [ X bam-1807 341 2 4 4 NUM bam-1807 341 3 ] ] X bam-1807 341 4 armstrong armstrong PROPN bam-1807 341 5 l l PROPN bam-1807 341 6 , , PUNCT bam-1807 341 7 whaley whaley PROPN bam-1807 341 8 mh mh PROPN bam-1807 341 9 , , PUNCT bam-1807 341 10 brubaker brubaker PROPN bam-1807 341 11 ph ph PROPN bam-1807 341 12 , , PUNCT bam-1807 341 13 otto otto PROPN bam-1807 341 14 rm rm PROPN bam-1807 341 15 , , PUNCT bam-1807 341 16 acsm acsm PROPN bam-1807 341 17 's 's PART bam-1807 341 18 guidelines guideline NOUN bam-1807 341 19 for for ADP bam-1807 341 20 exercise exercise NOUN bam-1807 341 21 testing testing NOUN bam-1807 341 22 and and CCONJ bam-1807 341 23 prescription prescription NOUN bam-1807 341 24 2006 2006 NUM bam-1807 341 25 , , PUNCT bam-1807 341 26 lippincott lippincott PROPN bam-1807 341 27 williams williams PROPN bam-1807 341 28 & & CCONJ bam-1807 341 29 wilkins wilkins PROPN bam-1807 341 30 , , PUNCT bam-1807 341 31 usa usa PROPN bam-1807 341 32 . . PUNCT bam-1807 342 1 [ [ X bam-1807 342 2 5 5 NUM bam-1807 342 3 ] ] X bam-1807 342 4 atherton atherton PROPN bam-1807 342 5 pj pj PROPN bam-1807 342 6 , , PUNCT bam-1807 342 7 babraj babraj PROPN bam-1807 342 8 j j PROPN bam-1807 342 9 , , PUNCT bam-1807 342 10 smith smith PROPN bam-1807 342 11 k k PROPN bam-1807 342 12 , , PUNCT bam-1807 342 13 singh singh PROPN bam-1807 342 14 j j PROPN bam-1807 342 15 , , PUNCT bam-1807 342 16 rennie rennie PROPN bam-1807 342 17 mj mj PROPN bam-1807 342 18 , , PUNCT bam-1807 342 19 wackerhage wackerhage NOUN bam-1807 342 20 h.selective h.selective ADJ bam-1807 342 21 activation activation NOUN bam-1807 342 22 of of ADP bam-1807 342 23 ampk ampk NOUN bam-1807 342 24 - - PUNCT bam-1807 342 25 pgc-1alpha pgc-1alpha NOUN bam-1807 342 26 or or CCONJ bam-1807 342 27 pkb pkb PROPN bam-1807 342 28 - - PUNCT bam-1807 342 29 tsc2 tsc2 PROPN bam-1807 342 30 - - PUNCT bam-1807 342 31 mtor mtor NOUN bam-1807 342 32 signaling signal VERB bam-1807 342 33 can can AUX bam-1807 342 34 explain explain VERB bam-1807 342 35 specific specific ADJ bam-1807 342 36 adaptive adaptive ADJ bam-1807 342 37 responses response NOUN bam-1807 342 38 to to ADP bam-1807 342 39 endurance endurance NOUN bam-1807 342 40 or or CCONJ bam-1807 342 41 resistance resistance NOUN bam-1807 342 42 traininglike traininglike ADJ bam-1807 342 43 electrical electrical ADJ bam-1807 342 44 muscle muscle NOUN bam-1807 342 45 stimulation.faseb stimulation.faseb NOUN bam-1807 342 46 j. j. PROPN bam-1807 342 47 2005 2005 NUM bam-1807 342 48 ; ; PUNCT bam-1807 342 49 19 19 NUM bam-1807 342 50 : : SYM bam-1807 342 51 786 786 NUM bam-1807 342 52 - - SYM bam-1807 342 53 788 788 NUM bam-1807 342 54 . . PUNCT bam-1807 343 1 [ [ X bam-1807 343 2 6 6 NUM bam-1807 343 3 ] ] PUNCT bam-1807 343 4 baar baar PROPN bam-1807 343 5 k k PROPN bam-1807 343 6 , , PUNCT bam-1807 343 7 the the DET bam-1807 343 8 signaling signal VERB bam-1807 343 9 underlying underlie VERB bam-1807 343 10 fitness fitness NOUN bam-1807 343 11 , , PUNCT bam-1807 343 12 appl appl PROPN bam-1807 343 13 physiol physiol PROPN bam-1807 343 14 nutr nutr PROPN bam-1807 343 15 metab metab PROPN bam-1807 343 16 2009 2009 NUM bam-1807 343 17 ; ; PUNCT bam-1807 343 18 34 34 NUM bam-1807 343 19 : : PUNCT bam-1807 343 20 411–419 411–419 NUM bam-1807 343 21 . . PUNCT bam-1807 344 1 [ [ X bam-1807 344 2 7 7 NUM bam-1807 344 3 ] ] X bam-1807 344 4 balon balon PROPN bam-1807 344 5 tw tw PROPN bam-1807 344 6 , , PUNCT bam-1807 344 7 nadler nadler PROPN bam-1807 344 8 jl jl PROPN bam-1807 344 9 . . PROPN bam-1807 344 10 nitric nitric ADJ bam-1807 344 11 oxide oxide NOUN bam-1807 344 12 release release NOUN bam-1807 344 13 is be AUX bam-1807 344 14 present present ADJ bam-1807 344 15 from from ADP bam-1807 344 16 incubated incubate VERB bam-1807 344 17 skeletal skeletal ADJ bam-1807 344 18 muscle muscle NOUN bam-1807 344 19 preparations preparation NOUN bam-1807 344 20 . . PUNCT bam-1807 345 1 j. j. PROPN bam-1807 345 2 appl appl PROPN bam-1807 345 3 . . PUNCT bam-1807 345 4 physiol physiol PROPN bam-1807 345 5 . . PUNCT bam-1807 346 1 1994 1994 NUM bam-1807 346 2 ; ; PUNCT bam-1807 347 1 77:25192521 77:25192521 NUM bam-1807 347 2 . . PUNCT bam-1807 348 1 [ [ X bam-1807 348 2 8 8 NUM bam-1807 348 3 ] ] X bam-1807 348 4 bellinger bellinger NOUN bam-1807 348 5 am be AUX bam-1807 348 6 , , PUNCT bam-1807 348 7 mongillo mongillo PROPN bam-1807 348 8 m m PROPN bam-1807 348 9 , , PUNCT bam-1807 348 10 marks marks PROPN bam-1807 348 11 ar ar PROPN bam-1807 348 12 . . PROPN bam-1807 348 13 stressed stress VERB bam-1807 348 14 out out ADP bam-1807 348 15 : : PUNCT bam-1807 348 16 the the DET bam-1807 348 17 skeletal skeletal ADJ bam-1807 348 18 muscle muscle NOUN bam-1807 348 19 ryanodine ryanodine NOUN bam-1807 348 20 receptor receptor NOUN bam-1807 348 21 as as ADP bam-1807 348 22 a a DET bam-1807 348 23 target target NOUN bam-1807 348 24 of of ADP bam-1807 348 25 stress stress NOUN bam-1807 348 26 . . PUNCT bam-1807 349 1 j. j. PROPN bam-1807 349 2 clin clin PROPN bam-1807 349 3 . . PUNCT bam-1807 350 1 invest invest PROPN bam-1807 350 2 . . PUNCT bam-1807 351 1 2008 2008 NUM bam-1807 351 2 ; ; PUNCT bam-1807 351 3 118:445 118:445 NOUN bam-1807 351 4 - - SYM bam-1807 351 5 453 453 NUM bam-1807 351 6 . . PUNCT bam-1807 352 1 [ [ X bam-1807 352 2 9 9 NUM bam-1807 352 3 ] ] PUNCT bam-1807 352 4 blair blair PROPN bam-1807 352 5 sn sn PROPN bam-1807 352 6 , , PUNCT bam-1807 352 7 lamonte lamonte PROPN bam-1807 352 8 mj mj PROPN bam-1807 352 9 , , PUNCT bam-1807 352 10 nichaman nichaman PROPN bam-1807 352 11 mz mz PROPN bam-1807 352 12 . . PUNCT bam-1807 353 1 the the DET bam-1807 353 2 evolution evolution NOUN bam-1807 353 3 of of ADP bam-1807 353 4 physical physical ADJ bam-1807 353 5 activity activity NOUN bam-1807 353 6 recommendations recommendation NOUN bam-1807 353 7 : : PUNCT bam-1807 353 8 how how SCONJ bam-1807 353 9 much much ADJ bam-1807 353 10 is be AUX bam-1807 353 11 enough enough ADJ bam-1807 353 12 ? ? PUNCT bam-1807 354 1 am be AUX bam-1807 354 2 . . PUNCT bam-1807 355 1 j. j. PROPN bam-1807 355 2 clin clin PROPN bam-1807 355 3 . . PUNCT bam-1807 356 1 nutr nutr PROPN bam-1807 356 2 . . PROPN bam-1807 356 3 2004 2004 NUM bam-1807 356 4 ; ; PUNCT bam-1807 357 1 79:913s-920s 79:913s-920s X bam-1807 357 2 . . PUNCT bam-1807 358 1 [ [ X bam-1807 358 2 10 10 NUM bam-1807 358 3 ] ] X bam-1807 358 4 bloor bloor PROPN bam-1807 358 5 cm cm PROPN bam-1807 358 6 . . PUNCT bam-1807 359 1 angiogenesis angiogenesis NOUN bam-1807 359 2 during during ADP bam-1807 359 3 exercise exercise NOUN bam-1807 359 4 and and CCONJ bam-1807 359 5 training training NOUN bam-1807 359 6 . . PUNCT bam-1807 360 1 angiogenesis angiogenesis NOUN bam-1807 360 2 . . PUNCT bam-1807 361 1 2005 2005 NUM bam-1807 361 2 ; ; PUNCT bam-1807 361 3 8:263 8:263 NUM bam-1807 361 4 - - PUNCT bam-1807 361 5 271 271 NUM bam-1807 361 6 . . PUNCT bam-1807 362 1 [ [ X bam-1807 362 2 11 11 NUM bam-1807 362 3 ] ] X bam-1807 362 4 bodine bodine PROPN bam-1807 362 5 sc sc PROPN bam-1807 362 6 , , PUNCT bam-1807 362 7 latres latre NOUN bam-1807 362 8 e e PROPN bam-1807 362 9 , , PUNCT bam-1807 362 10 baumhueter baumhueter PROPN bam-1807 362 11 s s PROPN bam-1807 362 12 , , PUNCT bam-1807 362 13 lai lai PROPN bam-1807 362 14 vk vk PROPN bam-1807 362 15 , , PUNCT bam-1807 362 16 nunez nunez PROPN bam-1807 362 17 l l PROPN bam-1807 362 18 , , PUNCT bam-1807 362 19 clarke clarke PROPN bam-1807 362 20 ba ba PROPN bam-1807 362 21 , , PUNCT bam-1807 362 22 poueymirou poueymirou PROPN bam-1807 362 23 wt wt PROPN bam-1807 362 24 , , PUNCT bam-1807 362 25 panaro panaro NOUN bam-1807 362 26 fj fj X bam-1807 362 27 , , PUNCT bam-1807 362 28 na na PART bam-1807 362 29 e e NOUN bam-1807 362 30 , , PUNCT bam-1807 362 31 dharmarajan dharmarajan PROPN bam-1807 362 32 k k PROPN bam-1807 362 33 , , PUNCT bam-1807 362 34 pan pan PROPN bam-1807 362 35 zq zq PROPN bam-1807 362 36 , , PUNCT bam-1807 362 37 valenzuela valenzuela PROPN bam-1807 362 38 dm dm PROPN bam-1807 362 39 , , PUNCT bam-1807 362 40 dechiara dechiara PROPN bam-1807 362 41 tm tm PROPN bam-1807 362 42 , , PUNCT bam-1807 362 43 stitt stitt PROPN bam-1807 362 44 tn tn PROPN bam-1807 362 45 , , PUNCT bam-1807 362 46 yancopoulos yancopoulos PROPN bam-1807 362 47 gd gd NOUN bam-1807 362 48 , , PUNCT bam-1807 362 49 glass glass NOUN bam-1807 362 50 dj dj NOUN bam-1807 362 51 . . PUNCT bam-1807 362 52 identification identification NOUN bam-1807 362 53 of of ADP bam-1807 362 54 ubiquitin ubiquitin ADJ bam-1807 362 55 ligases ligase NOUN bam-1807 362 56 required require VERB bam-1807 362 57 for for ADP bam-1807 362 58 skeletal skeletal ADJ bam-1807 362 59 muscle muscle NOUN bam-1807 362 60 atrophy atrophy NOUN bam-1807 362 61 . . PUNCT bam-1807 363 1 science science NOUN bam-1807 363 2 . . PUNCT bam-1807 364 1 2001 2001 NUM bam-1807 364 2 ; ; PUNCT bam-1807 364 3 294:1704 294:1704 NUM bam-1807 364 4 - - NOUN bam-1807 364 5 1708 1708 NUM bam-1807 364 6 . . PUNCT bam-1807 365 1 [ [ X bam-1807 365 2 12 12 NUM bam-1807 365 3 ] ] SYM bam-1807 365 4 bonacci bonacci PROPN bam-1807 365 5 j j PROPN bam-1807 365 6 , , PUNCT bam-1807 365 7 chapman chapman PROPN bam-1807 365 8 a a PROPN bam-1807 365 9 , , PUNCT bam-1807 365 10 blanch blanch NOUN bam-1807 365 11 p p NOUN bam-1807 365 12 , , PUNCT bam-1807 365 13 vicenzino vicenzino PROPN bam-1807 365 14 b. b. PROPN bam-1807 365 15 neuromuscular neuromuscular ADJ bam-1807 365 16 adaptations adaptation NOUN bam-1807 365 17 to to ADP bam-1807 365 18 training training NOUN bam-1807 365 19 , , PUNCT bam-1807 365 20 injury injury NOUN bam-1807 365 21 and and CCONJ bam-1807 365 22 passive passive ADJ bam-1807 365 23 interventions intervention NOUN bam-1807 365 24 : : PUNCT bam-1807 365 25 implications implication NOUN bam-1807 365 26 for for ADP bam-1807 365 27 running run VERB bam-1807 365 28 economy economy NOUN bam-1807 365 29 . . PUNCT bam-1807 366 1 sports sport NOUN bam-1807 366 2 med med PROPN bam-1807 366 3 . . PUNCT bam-1807 366 4 2009 2009 NUM bam-1807 366 5 ; ; PUNCT bam-1807 366 6 39:903921 39:903921 X bam-1807 366 7 . . PUNCT bam-1807 367 1 [ [ X bam-1807 367 2 13 13 NUM bam-1807 367 3 ] ] X bam-1807 367 4 brooks brooks PROPN bam-1807 367 5 sv sv PROPN bam-1807 367 6 , , PUNCT bam-1807 367 7 vasilaki vasilaki PROPN bam-1807 367 8 a a PRON bam-1807 367 9 , , PUNCT bam-1807 367 10 larkin larkin PROPN bam-1807 367 11 lm lm PROPN bam-1807 367 12 , , PUNCT bam-1807 367 13 mcardle mcardle PROPN bam-1807 367 14 a a PROPN bam-1807 367 15 , , PUNCT bam-1807 367 16 jackson jackson PROPN bam-1807 367 17 mj mj PROPN bam-1807 367 18 . . PROPN bam-1807 367 19 repeated repeat VERB bam-1807 367 20 bouts bout NOUN bam-1807 367 21 of of ADP bam-1807 367 22 aerobic aerobic ADJ bam-1807 367 23 exercise exercise NOUN bam-1807 367 24 lead lead NOUN bam-1807 367 25 to to ADP bam-1807 367 26 reductions reduction NOUN bam-1807 367 27 in in ADP bam-1807 367 28 skeletal skeletal ADJ bam-1807 367 29 muscle muscle NOUN bam-1807 367 30 free free ADJ bam-1807 367 31 radical radical ADJ bam-1807 367 32 generation generation NOUN bam-1807 367 33 and and CCONJ bam-1807 367 34 nuclear nuclear ADJ bam-1807 367 35 factor factor NOUN bam-1807 367 36 kappab kappab NOUN bam-1807 367 37 activation activation NOUN bam-1807 367 38 . . PUNCT bam-1807 368 1 j. j. PROPN bam-1807 368 2 physiol physiol PROPN bam-1807 368 3 . . PUNCT bam-1807 369 1 2008 2008 NUM bam-1807 369 2 ; ; PUNCT bam-1807 369 3 586:39793790 586:39793790 NUM bam-1807 369 4 . . PUNCT bam-1807 370 1 [ [ X bam-1807 370 2 14 14 NUM bam-1807 370 3 ] ] X bam-1807 370 4 cameron cameron PROPN bam-1807 370 5 - - PUNCT bam-1807 370 6 smith smith PROPN bam-1807 370 7 d. d. PROPN bam-1807 370 8 exercise exercise PROPN bam-1807 370 9 and and CCONJ bam-1807 370 10 skeletal skeletal ADJ bam-1807 370 11 muscle muscle NOUN bam-1807 370 12 gene gene NOUN bam-1807 370 13 expression expression NOUN bam-1807 370 14 . . PUNCT bam-1807 371 1 clin clin PROPN bam-1807 371 2 exp exp PROPN bam-1807 371 3 pharmacol pharmacol PROPN bam-1807 371 4 physiol physiol PROPN bam-1807 371 5 2002 2002 NUM bam-1807 371 6 ; ; PUNCT bam-1807 371 7 29:209–213 29:209–213 NUM bam-1807 371 8 . . PUNCT bam-1807 372 1 [ [ X bam-1807 372 2 15 15 NUM bam-1807 372 3 ] ] X bam-1807 372 4 cantó cantó PROPN bam-1807 372 5 c c PROPN bam-1807 372 6 , , PUNCT bam-1807 372 7 gerhart gerhart NOUN bam-1807 372 8 - - PUNCT bam-1807 372 9 hines hines PROPN bam-1807 372 10 z z PROPN bam-1807 372 11 , , PUNCT bam-1807 372 12 feige feige PROPN bam-1807 372 13 jn jn PROPN bam-1807 372 14 , , PUNCT bam-1807 372 15 lagouge lagouge VERB bam-1807 372 16 m m PROPN bam-1807 372 17 , , PUNCT bam-1807 372 18 noriega noriega PROPN bam-1807 372 19 l l PROPN bam-1807 372 20 , , PUNCT bam-1807 372 21 milne milne PROPN bam-1807 372 22 jc jc PROPN bam-1807 372 23 , , PUNCT bam-1807 372 24 elliott elliott PROPN bam-1807 372 25 pj pj PROPN bam-1807 372 26 , , PUNCT bam-1807 372 27 puigserver puigserver PROPN bam-1807 372 28 p p NOUN bam-1807 372 29 , , PUNCT bam-1807 372 30 auwerx auwerx ADJ bam-1807 372 31 j. j. PROPN bam-1807 372 32 ampk ampk PROPN bam-1807 372 33 regulates regulate VERB bam-1807 372 34 energy energy NOUN bam-1807 372 35 expenditure expenditure NOUN bam-1807 372 36 by by ADP bam-1807 372 37 modulating modulate VERB bam-1807 372 38 nad(+ nad(+ PROPN bam-1807 372 39 ) ) PUNCT bam-1807 372 40 metabolism metabolism NOUN bam-1807 372 41 and and CCONJ bam-1807 372 42 sirt1 sirt1 NOUN bam-1807 372 43 activity activity NOUN bam-1807 372 44 . . PUNCT bam-1807 373 1 nature nature NOUN bam-1807 373 2 2009 2009 NUM bam-1807 373 3 ; ; PUNCT bam-1807 373 4 458:10561060 458:10561060 NOUN bam-1807 373 5 . . PUNCT bam-1807 374 1 [ [ X bam-1807 374 2 16 16 NUM bam-1807 374 3 ] ] X bam-1807 374 4 cheek cheek NOUN bam-1807 374 5 db db PROPN bam-1807 374 6 . . PUNCT bam-1807 375 1 the the DET bam-1807 375 2 control control NOUN bam-1807 375 3 of of ADP bam-1807 375 4 cell cell NOUN bam-1807 375 5 mass mass NOUN bam-1807 375 6 and and CCONJ bam-1807 375 7 replication replication NOUN bam-1807 375 8 . . PUNCT bam-1807 376 1 the the DET bam-1807 376 2 dna dna PROPN bam-1807 376 3 unit unit NOUN bam-1807 376 4 – – PUNCT bam-1807 376 5 a a DET bam-1807 376 6 personal personal ADJ bam-1807 376 7 20 20 NUM bam-1807 376 8 - - PUNCT bam-1807 376 9 year year NOUN bam-1807 376 10 study study NOUN bam-1807 376 11 . . PUNCT bam-1807 377 1 early early ADV bam-1807 377 2 . . PUNCT bam-1807 378 1 hum hum ADJ bam-1807 378 2 . . PUNCT bam-1807 379 1 dev dev PROPN bam-1807 379 2 . . PROPN bam-1807 380 1 1985 1985 NUM bam-1807 380 2 ; ; PUNCT bam-1807 380 3 12 12 NUM bam-1807 380 4 : : PUNCT bam-1807 380 5 211–239 211–239 NUM bam-1807 380 6 . . PUNCT bam-1807 381 1 the the DET bam-1807 381 2 exercised exercise VERB bam-1807 381 3 skeletal skeletal ADJ bam-1807 381 4 muscle muscle NOUN bam-1807 381 5 european european PROPN bam-1807 381 6 journal journal PROPN bam-1807 381 7 translational translational ADJ bam-1807 381 8 myology myology NOUN bam-1807 381 9 myology myology NOUN bam-1807 381 10 reviews review VERB bam-1807 381 11 20 20 NUM bam-1807 381 12 ( ( PUNCT bam-1807 381 13 3 3 NUM bam-1807 381 14 ): ): PUNCT bam-1807 381 15 105 105 NUM bam-1807 381 16 - - SYM bam-1807 381 17 120 120 NUM bam-1807 381 18 , , PUNCT bam-1807 381 19 2010 2010 NUM bam-1807 381 20 116 116 NUM bam-1807 382 1 [ [ X bam-1807 382 2 17 17 NUM bam-1807 382 3 ] ] X bam-1807 382 4 csordás csordás PROPN bam-1807 382 5 g g PROPN bam-1807 382 6 , , PUNCT bam-1807 382 7 hajnóczky hajnóczky PROPN bam-1807 382 8 g. g. PROPN bam-1807 382 9 sr sr PROPN bam-1807 382 10 / / SYM bam-1807 382 11 er er INTJ bam-1807 382 12 - - PUNCT bam-1807 382 13 mitochondrial mitochondrial ADJ bam-1807 382 14 local local ADJ bam-1807 382 15 communication communication NOUN bam-1807 382 16 : : PUNCT bam-1807 382 17 calcium calcium NOUN bam-1807 382 18 and and CCONJ bam-1807 382 19 ros ros PROPN bam-1807 382 20 . . PROPN bam-1807 382 21 biochim biochim PROPN bam-1807 382 22 . . PUNCT bam-1807 383 1 biophys biophy NOUN bam-1807 383 2 . . PUNCT bam-1807 384 1 acta acta PROPN bam-1807 384 2 2009 2009 NUM bam-1807 384 3 ; ; PUNCT bam-1807 384 4 1787:1352 1787:1352 NUM bam-1807 384 5 - - SYM bam-1807 384 6 1362 1362 NUM bam-1807 384 7 . . PUNCT bam-1807 385 1 [ [ X bam-1807 385 2 18 18 NUM bam-1807 385 3 ] ] X bam-1807 385 4 cully cully PROPN bam-1807 385 5 m m PROPN bam-1807 385 6 , , PUNCT bam-1807 385 7 downward downward ADJ bam-1807 385 8 j. j. PROPN bam-1807 385 9 translational translational PROPN bam-1807 385 10 responses response NOUN bam-1807 385 11 to to ADP bam-1807 385 12 growth growth NOUN bam-1807 385 13 factors factor NOUN bam-1807 385 14 and and CCONJ bam-1807 385 15 stress stress NOUN bam-1807 385 16 . . PUNCT bam-1807 386 1 biochem biochem PROPN bam-1807 386 2 . . PUNCT bam-1807 387 1 soc soc PROPN bam-1807 387 2 . . PUNCT bam-1807 388 1 trans trans PROPN bam-1807 388 2 . . PROPN bam-1807 388 3 2009 2009 NUM bam-1807 388 4 ; ; PUNCT bam-1807 388 5 37(pt 37(pt NUM bam-1807 388 6 1):284 1):284 NUM bam-1807 388 7 - - SYM bam-1807 388 8 288 288 NUM bam-1807 388 9 . . PUNCT bam-1807 389 1 [ [ X bam-1807 389 2 19 19 NUM bam-1807 389 3 ] ] X bam-1807 389 4 däpp däpp PROPN bam-1807 389 5 c c NOUN bam-1807 389 6 , , PUNCT bam-1807 389 7 gassmann gassmann PROPN bam-1807 389 8 m m PROPN bam-1807 389 9 , , PUNCT bam-1807 389 10 hoppeler hoppeler ADJ bam-1807 389 11 h h PROPN bam-1807 389 12 , , PUNCT bam-1807 389 13 flück flück PROPN bam-1807 389 14 m. m. NOUN bam-1807 389 15 hypoxia hypoxia NOUN bam-1807 389 16 - - PUNCT bam-1807 389 17 induced induce VERB bam-1807 389 18 gene gene NOUN bam-1807 389 19 activity activity NOUN bam-1807 389 20 in in ADP bam-1807 389 21 disused disuse VERB bam-1807 389 22 oxidative oxidative ADJ bam-1807 389 23 muscle muscle NOUN bam-1807 389 24 . . PUNCT bam-1807 390 1 adv adv PROPN bam-1807 390 2 . . PUNCT bam-1807 391 1 exp exp PROPN bam-1807 391 2 . . PROPN bam-1807 391 3 med med PROPN bam-1807 391 4 . . PUNCT bam-1807 392 1 biol biol PROPN bam-1807 392 2 . . PUNCT bam-1807 393 1 2006 2006 NUM bam-1807 393 2 ; ; PUNCT bam-1807 393 3 588:171–188 588:171–188 NUM bam-1807 393 4 . . PUNCT bam-1807 394 1 [ [ X bam-1807 394 2 20 20 NUM bam-1807 394 3 ] ] X bam-1807 394 4 davies davies PROPN bam-1807 394 5 kja kja PROPN bam-1807 394 6 , , PUNCT bam-1807 394 7 quintanilla quintanilla VERB bam-1807 394 8 at at ADP bam-1807 394 9 , , PUNCT bam-1807 394 10 brooks brooks PROPN bam-1807 394 11 ga ga PROPN bam-1807 394 12 , , PUNCT bam-1807 394 13 parker parker PROPN bam-1807 394 14 l. l. PROPN bam-1807 394 15 free free PROPN bam-1807 394 16 radicals radical NOUN bam-1807 394 17 and and CCONJ bam-1807 394 18 tissue tissue NOUN bam-1807 394 19 damage damage NOUN bam-1807 394 20 produced produce VERB bam-1807 394 21 by by ADP bam-1807 394 22 exercise exercise NOUN bam-1807 394 23 . . PUNCT bam-1807 395 1 biochem biochem PROPN bam-1807 395 2 . . PUNCT bam-1807 396 1 biophys biophy NOUN bam-1807 396 2 . . PUNCT bam-1807 397 1 res re NOUN bam-1807 397 2 . . PUNCT bam-1807 398 1 commun commun PROPN bam-1807 398 2 . . PUNCT bam-1807 399 1 1982 1982 NUM bam-1807 399 2 ; ; PUNCT bam-1807 399 3 107:1198 107:1198 NUM bam-1807 399 4 - - SYM bam-1807 399 5 1205 1205 NUM bam-1807 399 6 . . PUNCT bam-1807 400 1 [ [ X bam-1807 400 2 21 21 NUM bam-1807 400 3 ] ] X bam-1807 400 4 di di NOUN bam-1807 400 5 francescomarino francescomarino NOUN bam-1807 400 6 s s PROPN bam-1807 400 7 , , PUNCT bam-1807 400 8 sciartilli sciartilli NOUN bam-1807 400 9 a a PROPN bam-1807 400 10 , , PUNCT bam-1807 400 11 di di PROPN bam-1807 400 12 valerio valerio PROPN bam-1807 400 13 v v PROPN bam-1807 400 14 , , PUNCT bam-1807 400 15 di di X bam-1807 400 16 baldassarre baldassarre PROPN bam-1807 400 17 a a DET bam-1807 400 18 , , PUNCT bam-1807 400 19 gallina gallina PROPN bam-1807 400 20 s. s. PROPN bam-1807 400 21 the the DET bam-1807 400 22 effect effect NOUN bam-1807 400 23 of of ADP bam-1807 400 24 physical physical ADJ bam-1807 400 25 exercise exercise NOUN bam-1807 400 26 on on ADP bam-1807 400 27 endothelial endothelial ADJ bam-1807 400 28 function function NOUN bam-1807 400 29 . . PUNCT bam-1807 401 1 sports sport NOUN bam-1807 401 2 med med PROPN bam-1807 401 3 . . PUNCT bam-1807 401 4 2009 2009 NUM bam-1807 401 5 ; ; PUNCT bam-1807 401 6 39:797 39:797 NUM bam-1807 401 7 - - SYM bam-1807 401 8 812 812 NUM bam-1807 401 9 . . PUNCT bam-1807 402 1 [ [ X bam-1807 402 2 22 22 NUM bam-1807 402 3 ] ] PUNCT bam-1807 402 4 dipenta dipenta PROPN bam-1807 402 5 jm jm PROPN bam-1807 402 6 , , PUNCT bam-1807 402 7 green green PROPN bam-1807 402 8 - - PUNCT bam-1807 402 9 johnson johnson PROPN bam-1807 402 10 jm jm PROPN bam-1807 402 11 , , PUNCT bam-1807 402 12 murphy murphy PROPN bam-1807 402 13 rj rj PROPN bam-1807 402 14 . . PUNCT bam-1807 402 15 type type NOUN bam-1807 402 16 2 2 NUM bam-1807 402 17 diabetes diabetes NOUN bam-1807 402 18 mellitus mellitus NOUN bam-1807 402 19 , , PUNCT bam-1807 402 20 resistance resistance NOUN bam-1807 402 21 training training NOUN bam-1807 402 22 , , PUNCT bam-1807 402 23 and and CCONJ bam-1807 402 24 innate innate ADJ bam-1807 402 25 immunity immunity NOUN bam-1807 402 26 : : PUNCT bam-1807 402 27 is be AUX bam-1807 402 28 there there PRON bam-1807 402 29 a a DET bam-1807 402 30 common common ADJ bam-1807 402 31 link link NOUN bam-1807 402 32 ? ? PUNCT bam-1807 403 1 appl appl PROPN bam-1807 403 2 . . PUNCT bam-1807 403 3 physiol physiol PROPN bam-1807 403 4 . . PUNCT bam-1807 404 1 nutr nutr PROPN bam-1807 404 2 . . PUNCT bam-1807 404 3 metab metab PROPN bam-1807 404 4 . . PUNCT bam-1807 405 1 2007 2007 NUM bam-1807 405 2 ; ; PUNCT bam-1807 405 3 32:10251035 32:10251035 NUM bam-1807 405 4 . . PUNCT bam-1807 406 1 [ [ X bam-1807 406 2 23 23 NUM bam-1807 406 3 ] ] PUNCT bam-1807 406 4 duhamel duhamel VERB bam-1807 406 5 ta ta PROPN bam-1807 406 6 , , PUNCT bam-1807 406 7 stewart stewart PROPN bam-1807 406 8 rd rd PROPN bam-1807 406 9 , , PUNCT bam-1807 406 10 tupling tuple VERB bam-1807 406 11 ar ar PROPN bam-1807 406 12 , , PUNCT bam-1807 406 13 ouyang ouyang PROPN bam-1807 406 14 j j PROPN bam-1807 406 15 , , PUNCT bam-1807 406 16 green green PROPN bam-1807 406 17 hj hj PROPN bam-1807 406 18 . . PROPN bam-1807 406 19 muscle muscle NOUN bam-1807 406 20 sarcoplasmic sarcoplasmic NOUN bam-1807 406 21 reticulum reticulum NOUN bam-1807 406 22 calcium calcium NOUN bam-1807 406 23 regulation regulation NOUN bam-1807 406 24 in in ADP bam-1807 406 25 humans human NOUN bam-1807 406 26 during during ADP bam-1807 406 27 consecutive consecutive ADJ bam-1807 406 28 days day NOUN bam-1807 406 29 of of ADP bam-1807 406 30 exercise exercise NOUN bam-1807 406 31 and and CCONJ bam-1807 406 32 recovery recovery NOUN bam-1807 406 33 . . PUNCT bam-1807 407 1 j. j. PROPN bam-1807 407 2 appl appl PROPN bam-1807 407 3 . . PUNCT bam-1807 407 4 physiol physiol PROPN bam-1807 407 5 . . PUNCT bam-1807 408 1 2007 2007 NUM bam-1807 408 2 ; ; PUNCT bam-1807 408 3 103:1212 103:1212 NUM bam-1807 408 4 - - SYM bam-1807 408 5 20 20 NUM bam-1807 408 6 . . PUNCT bam-1807 409 1 [ [ X bam-1807 409 2 24 24 NUM bam-1807 409 3 ] ] PUNCT bam-1807 409 4 ebashi ebashi NOUN bam-1807 409 5 , , PUNCT bam-1807 409 6 s. s. PROPN bam-1807 409 7 excitation excitation PROPN bam-1807 409 8 - - PUNCT bam-1807 409 9 contraction contraction NOUN bam-1807 409 10 coupling coupling NOUN bam-1807 409 11 and and CCONJ bam-1807 409 12 the the DET bam-1807 409 13 mechanism mechanism NOUN bam-1807 409 14 of of ADP bam-1807 409 15 muscle muscle NOUN bam-1807 409 16 contraction contraction NOUN bam-1807 409 17 . . PUNCT bam-1807 410 1 annu annu NOUN bam-1807 410 2 . . PUNCT bam-1807 411 1 rev rev PROPN bam-1807 411 2 . . PROPN bam-1807 411 3 physiol physiol PROPN bam-1807 411 4 . . PUNCT bam-1807 412 1 1991 1991 NUM bam-1807 412 2 ; ; PUNCT bam-1807 412 3 53:1–16 53:1–16 NUM bam-1807 412 4 . . PUNCT bam-1807 413 1 [ [ X bam-1807 413 2 25 25 NUM bam-1807 413 3 ] ] X bam-1807 413 4 egginton egginton PROPN bam-1807 413 5 s s PROPN bam-1807 413 6 , , PUNCT bam-1807 413 7 zhou zhou PROPN bam-1807 413 8 al al PROPN bam-1807 413 9 , , PUNCT bam-1807 413 10 brown brown PROPN bam-1807 413 11 md md PROPN bam-1807 413 12 , , PUNCT bam-1807 413 13 hudlická hudlická NOUN bam-1807 413 14 o. o. NOUN bam-1807 413 15 unorthodox unorthodox ADJ bam-1807 413 16 angiogenesis angiogenesis NOUN bam-1807 413 17 in in ADP bam-1807 413 18 skeletal skeletal ADJ bam-1807 413 19 muscle muscle NOUN bam-1807 413 20 . . PUNCT bam-1807 414 1 cardiovasc cardiovasc PROPN bam-1807 414 2 . . PUNCT bam-1807 415 1 res res PROPN bam-1807 415 2 . . PUNCT bam-1807 415 3 2001 2001 NUM bam-1807 415 4 ; ; PUNCT bam-1807 416 1 49:634–646 49:634–646 PROPN bam-1807 416 2 . . PUNCT bam-1807 417 1 [ [ X bam-1807 417 2 26 26 NUM bam-1807 417 3 ] ] X bam-1807 417 4 egginton egginton PROPN bam-1807 417 5 s. s. PROPN bam-1807 417 6 invited invite VERB bam-1807 417 7 review review NOUN bam-1807 417 8 : : PUNCT bam-1807 417 9 activity activity NOUN bam-1807 417 10 - - PUNCT bam-1807 417 11 induced induce VERB bam-1807 417 12 angiogenesis angiogenesis NOUN bam-1807 417 13 . . PUNCT bam-1807 418 1 pflugers pfluger NOUN bam-1807 418 2 arch arch VERB bam-1807 418 3 . . PUNCT bam-1807 419 1 2009 2009 NUM bam-1807 419 2 ; ; PUNCT bam-1807 419 3 457:963977 457:963977 NUM bam-1807 419 4 . . PUNCT bam-1807 420 1 [ [ X bam-1807 420 2 27 27 NUM bam-1807 420 3 ] ] X bam-1807 420 4 flück flück PROPN bam-1807 420 5 m m PROPN bam-1807 420 6 , , PUNCT bam-1807 420 7 hoppeler hoppeler PROPN bam-1807 420 8 h. h. PROPN bam-1807 420 9 molecular molecular ADJ bam-1807 420 10 basis basis NOUN bam-1807 420 11 of of ADP bam-1807 420 12 skeletal skeletal ADJ bam-1807 420 13 muscle muscle NOUN bam-1807 420 14 plasticity plasticity NOUN bam-1807 420 15 – – PUNCT bam-1807 420 16 from from ADP bam-1807 420 17 gene gene NOUN bam-1807 420 18 to to PART bam-1807 420 19 form form VERB bam-1807 420 20 and and CCONJ bam-1807 420 21 function function NOUN bam-1807 420 22 . . PUNCT bam-1807 421 1 rev rev PROPN bam-1807 421 2 physiol physiol PROPN bam-1807 421 3 biochem biochem PROPN bam-1807 421 4 pharmacol pharmacol PROPN bam-1807 421 5 2003 2003 NUM bam-1807 421 6 ; ; PUNCT bam-1807 421 7 146 146 NUM bam-1807 421 8 : : SYM bam-1807 421 9 159 159 NUM bam-1807 421 10 - - SYM bam-1807 421 11 216 216 NUM bam-1807 421 12 . . PUNCT bam-1807 422 1 [ [ X bam-1807 422 2 28 28 NUM bam-1807 422 3 ] ] X bam-1807 422 4 flück flück PROPN bam-1807 422 5 m. m. NOUN bam-1807 422 6 functional functional ADJ bam-1807 422 7 , , PUNCT bam-1807 422 8 structural structural ADJ bam-1807 422 9 and and CCONJ bam-1807 422 10 molecular molecular ADJ bam-1807 422 11 plasticity plasticity NOUN bam-1807 422 12 of of ADP bam-1807 422 13 mammalian mammalian ADJ bam-1807 422 14 skeletal skeletal ADJ bam-1807 422 15 muscle muscle NOUN bam-1807 422 16 in in ADP bam-1807 422 17 response response NOUN bam-1807 422 18 to to PART bam-1807 422 19 exercise exercise VERB bam-1807 422 20 stimuli stimulus NOUN bam-1807 422 21 . . PUNCT bam-1807 423 1 j. j. PROPN bam-1807 423 2 exp exp PROPN bam-1807 423 3 . . PUNCT bam-1807 424 1 biol biol PROPN bam-1807 424 2 . . PUNCT bam-1807 425 1 2006;209(pt 2006;209(pt NUM bam-1807 425 2 12):2239 12):2239 NUM bam-1807 425 3 - - PUNCT bam-1807 425 4 2248 2248 NUM bam-1807 425 5 . . PUNCT bam-1807 426 1 [ [ X bam-1807 426 2 29 29 NUM bam-1807 426 3 ] ] X bam-1807 426 4 freyssenet freyssenet PROPN bam-1807 426 5 d. d. PROPN bam-1807 426 6 energy energy NOUN bam-1807 426 7 sensing sensing NOUN bam-1807 426 8 and and CCONJ bam-1807 426 9 regulation regulation NOUN bam-1807 426 10 of of ADP bam-1807 426 11 gene gene NOUN bam-1807 426 12 expression expression NOUN bam-1807 426 13 in in ADP bam-1807 426 14 skeletal skeletal ADJ bam-1807 426 15 muscle muscle NOUN bam-1807 426 16 . . PUNCT bam-1807 427 1 j. j. PROPN bam-1807 427 2 appl appl PROPN bam-1807 427 3 . . PUNCT bam-1807 427 4 physiol physiol PROPN bam-1807 427 5 . . PUNCT bam-1807 428 1 2007 2007 NUM bam-1807 428 2 ; ; PUNCT bam-1807 428 3 102:529 102:529 NUM bam-1807 428 4 - - SYM bam-1807 428 5 540 540 NUM bam-1807 428 6 . . PUNCT bam-1807 429 1 [ [ X bam-1807 429 2 30 30 NUM bam-1807 429 3 ] ] X bam-1807 429 4 frost frost NOUN bam-1807 429 5 ra ra PROPN bam-1807 429 6 , , PUNCT bam-1807 429 7 huber huber PROPN bam-1807 429 8 d d PROPN bam-1807 429 9 , , PUNCT bam-1807 429 10 pruznak pruznak PROPN bam-1807 429 11 a a X bam-1807 429 12 , , PUNCT bam-1807 429 13 lang lang PROPN bam-1807 429 14 ch ch PROPN bam-1807 429 15 . . PUNCT bam-1807 430 1 regulation regulation NOUN bam-1807 430 2 of of ADP bam-1807 430 3 redd1 redd1 NOUN bam-1807 430 4 by by ADP bam-1807 430 5 insulin insulin NOUN bam-1807 430 6 - - PUNCT bam-1807 430 7 like like ADJ bam-1807 430 8 growth growth NOUN bam-1807 430 9 factor factor NOUN bam-1807 430 10 - - PUNCT bam-1807 430 11 i i PRON bam-1807 430 12 in in ADP bam-1807 430 13 skeletal skeletal ADJ bam-1807 430 14 muscle muscle NOUN bam-1807 430 15 and and CCONJ bam-1807 430 16 myotubes myotube NOUN bam-1807 430 17 . . PUNCT bam-1807 431 1 j. j. PROPN bam-1807 431 2 cell cell PROPN bam-1807 431 3 . . PUNCT bam-1807 432 1 biochem biochem PROPN bam-1807 432 2 . . PUNCT bam-1807 433 1 2009 2009 NUM bam-1807 433 2 ; ; PUNCT bam-1807 433 3 108:1192 108:1192 NUM bam-1807 433 4 - - SYM bam-1807 433 5 1202 1202 NUM bam-1807 433 6 . . PUNCT bam-1807 434 1 [ [ X bam-1807 434 2 31 31 NUM bam-1807 434 3 ] ] X bam-1807 434 4 gibala gibala PROPN bam-1807 434 5 mj mj PROPN bam-1807 434 6 , , PUNCT bam-1807 434 7 mcgee mcgee PROPN bam-1807 434 8 sl sl PROPN bam-1807 434 9 , , PUNCT bam-1807 434 10 garnham garnham NOUN bam-1807 434 11 ap ap PROPN bam-1807 434 12 , , PUNCT bam-1807 434 13 howlett howlett PROPN bam-1807 434 14 kf kf PROPN bam-1807 434 15 , , PUNCT bam-1807 434 16 snow snow PROPN bam-1807 434 17 rj rj PROPN bam-1807 434 18 , , PUNCT bam-1807 434 19 hargreaves hargreaves PROPN bam-1807 434 20 m. m. PROPN bam-1807 434 21 brief brief ADJ bam-1807 434 22 intense intense ADJ bam-1807 434 23 interval interval NOUN bam-1807 434 24 exercise exercise NOUN bam-1807 434 25 activates activate VERB bam-1807 434 26 ampk ampk NOUN bam-1807 434 27 and and CCONJ bam-1807 434 28 p38 p38 NOUN bam-1807 434 29 mapk mapk NOUN bam-1807 434 30 signaling signal VERB bam-1807 434 31 and and CCONJ bam-1807 434 32 increases increase VERB bam-1807 434 33 the the DET bam-1807 434 34 expression expression NOUN bam-1807 434 35 of of ADP bam-1807 434 36 pgc-1a pgc-1a NOUN bam-1807 434 37 in in ADP bam-1807 434 38 human human ADJ bam-1807 434 39 skeletal skeletal ADJ bam-1807 434 40 muscle muscle NOUN bam-1807 434 41 . . PUNCT bam-1807 435 1 j. j. PROPN bam-1807 435 2 appl appl PROPN bam-1807 435 3 . . PUNCT bam-1807 435 4 physiol physiol PROPN bam-1807 435 5 . . PUNCT bam-1807 436 1 2009 2009 NUM bam-1807 436 2 ; ; PUNCT bam-1807 436 3 106 106 NUM bam-1807 436 4 : : PUNCT bam-1807 437 1 929–934 929–934 NUM bam-1807 437 2 . . PUNCT bam-1807 438 1 [ [ X bam-1807 438 2 32 32 NUM bam-1807 438 3 ] ] X bam-1807 438 4 goberdhan goberdhan PROPN bam-1807 438 5 dc dc PROPN bam-1807 438 6 , , PUNCT bam-1807 438 7 ogmundsdóttir ogmundsdóttir PROPN bam-1807 438 8 mh mh PROPN bam-1807 438 9 , , PUNCT bam-1807 438 10 kazi kazi PROPN bam-1807 438 11 s s PROPN bam-1807 438 12 , , PUNCT bam-1807 438 13 reynolds reynolds PROPN bam-1807 438 14 b b PROPN bam-1807 438 15 , , PUNCT bam-1807 438 16 visvalingam visvalingam ADJ bam-1807 438 17 sm sm INTJ bam-1807 438 18 , , PUNCT bam-1807 438 19 wilson wilson PROPN bam-1807 438 20 c c PROPN bam-1807 438 21 , , PUNCT bam-1807 438 22 boyd boyd PROPN bam-1807 438 23 ca ca PROPN bam-1807 438 24 . . PUNCT bam-1807 439 1 amino amino NOUN bam-1807 439 2 acid acid NOUN bam-1807 439 3 sensing sensing NOUN bam-1807 439 4 and and CCONJ bam-1807 439 5 mtor mtor PROPN bam-1807 439 6 regulation regulation NOUN bam-1807 439 7 : : PUNCT bam-1807 439 8 inside inside ADV bam-1807 439 9 or or CCONJ bam-1807 439 10 out out ADV bam-1807 439 11 ? ? PUNCT bam-1807 440 1 biochem biochem PROPN bam-1807 440 2 . . PUNCT bam-1807 441 1 soc soc PROPN bam-1807 441 2 . . PUNCT bam-1807 442 1 trans trans PROPN bam-1807 442 2 . . PROPN bam-1807 442 3 2009 2009 NUM bam-1807 442 4 ; ; PUNCT bam-1807 442 5 37(pt 37(pt NUM bam-1807 442 6 1):248 1):248 NUM bam-1807 442 7 - - SYM bam-1807 442 8 252 252 NUM bam-1807 442 9 . . PUNCT bam-1807 443 1 [ [ X bam-1807 443 2 33 33 NUM bam-1807 443 3 ] ] X bam-1807 443 4 goldspink goldspink NOUN bam-1807 443 5 g. g. NOUN bam-1807 443 6 changes change NOUN bam-1807 443 7 in in ADP bam-1807 443 8 muscle muscle NOUN bam-1807 443 9 mass mass NOUN bam-1807 443 10 and and CCONJ bam-1807 443 11 phenotype phenotype NOUN bam-1807 443 12 and and CCONJ bam-1807 443 13 the the DET bam-1807 443 14 expression expression NOUN bam-1807 443 15 of of ADP bam-1807 443 16 autocrine autocrine NOUN bam-1807 443 17 and and CCONJ bam-1807 443 18 systemic systemic ADJ bam-1807 443 19 growth growth NOUN bam-1807 443 20 factors factor NOUN bam-1807 443 21 by by ADP bam-1807 443 22 muscle muscle NOUN bam-1807 443 23 in in ADP bam-1807 443 24 response response NOUN bam-1807 443 25 to to PART bam-1807 443 26 stretch stretch VERB bam-1807 443 27 and and CCONJ bam-1807 443 28 overload overload VERB bam-1807 443 29 . . PUNCT bam-1807 444 1 j. j. PROPN bam-1807 444 2 anat anat PROPN bam-1807 444 3 . . PUNCT bam-1807 444 4 1999 1999 NUM bam-1807 444 5 ; ; PUNCT bam-1807 444 6 194 194 NUM bam-1807 444 7 : : SYM bam-1807 444 8 323334 323334 NUM bam-1807 444 9 . . PUNCT bam-1807 445 1 [ [ X bam-1807 445 2 34 34 NUM bam-1807 445 3 ] ] X bam-1807 445 4 gomes gomes PROPN bam-1807 445 5 md md PROPN bam-1807 445 6 , , PUNCT bam-1807 445 7 lecker lecker PROPN bam-1807 445 8 sh sh PROPN bam-1807 445 9 , , PUNCT bam-1807 445 10 jagoe jagoe PROPN bam-1807 445 11 rt rt PROPN bam-1807 445 12 , , PUNCT bam-1807 445 13 navon navon PROPN bam-1807 445 14 a a PROPN bam-1807 445 15 , , PUNCT bam-1807 445 16 goldberg goldberg PROPN bam-1807 445 17 al al PROPN bam-1807 445 18 . . PROPN bam-1807 445 19 atrogin-1 atrogin-1 PROPN bam-1807 445 20 , , PUNCT bam-1807 445 21 a a DET bam-1807 445 22 muscle muscle NOUN bam-1807 445 23 - - PUNCT bam-1807 445 24 specific specific ADJ bam-1807 445 25 fbox fbox NOUN bam-1807 445 26 protein protein NOUN bam-1807 445 27 highly highly ADV bam-1807 445 28 expressed express VERB bam-1807 445 29 during during ADP bam-1807 445 30 muscle muscle NOUN bam-1807 445 31 atrophy atrophy NOUN bam-1807 445 32 . . PUNCT bam-1807 446 1 proc proc PROPN bam-1807 446 2 natl natl PROPN bam-1807 446 3 acad acad PROPN bam-1807 446 4 sci sci PROPN bam-1807 446 5 u u PROPN bam-1807 446 6 s s NOUN bam-1807 446 7 a. a. NOUN bam-1807 446 8 2001 2001 NUM bam-1807 446 9 ; ; PUNCT bam-1807 446 10 98:14440 98:14440 NUM bam-1807 446 11 - - SYM bam-1807 446 12 14445 14445 NUM bam-1807 446 13 . . PUNCT bam-1807 447 1 [ [ X bam-1807 447 2 35 35 NUM bam-1807 447 3 ] ] X bam-1807 447 4 gwinn gwinn PROPN bam-1807 447 5 dm dm PROPN bam-1807 447 6 , , PUNCT bam-1807 447 7 shackelford shackelford PROPN bam-1807 447 8 db db PROPN bam-1807 447 9 , , PUNCT bam-1807 447 10 egan egan PROPN bam-1807 447 11 df df PROPN bam-1807 447 12 , , PUNCT bam-1807 447 13 mihaylova mihaylova X bam-1807 447 14 mm mm PROPN bam-1807 447 15 , , PUNCT bam-1807 447 16 mery mery PROPN bam-1807 447 17 a a X bam-1807 447 18 , , PUNCT bam-1807 447 19 vasquez vasquez PROPN bam-1807 447 20 ds ds PROPN bam-1807 447 21 , , PUNCT bam-1807 447 22 turk turk PROPN bam-1807 447 23 be be VERB bam-1807 447 24 , , PUNCT bam-1807 447 25 shaw shaw PROPN bam-1807 447 26 rj rj PROPN bam-1807 447 27 . . PROPN bam-1807 448 1 ampk ampk PROPN bam-1807 448 2 phosphorylation phosphorylation PROPN bam-1807 448 3 of of ADP bam-1807 448 4 raptor raptor PROPN bam-1807 448 5 mediates mediate VERB bam-1807 448 6 a a DET bam-1807 448 7 metabolic metabolic NOUN bam-1807 448 8 checkpoint checkpoint NOUN bam-1807 448 9 . . PUNCT bam-1807 449 1 mol mol PROPN bam-1807 449 2 . . PROPN bam-1807 449 3 cell cell NOUN bam-1807 449 4 . . PUNCT bam-1807 450 1 2008 2008 NUM bam-1807 450 2 ; ; PUNCT bam-1807 450 3 30 30 NUM bam-1807 450 4 : : PUNCT bam-1807 450 5 214–226 214–226 NUM bam-1807 450 6 . . PUNCT bam-1807 451 1 [ [ X bam-1807 451 2 36 36 NUM bam-1807 451 3 ] ] X bam-1807 451 4 hawley hawley PROPN bam-1807 451 5 ja ja PROPN bam-1807 451 6 . . PUNCT bam-1807 452 1 molecular molecular ADJ bam-1807 452 2 responses response NOUN bam-1807 452 3 to to ADP bam-1807 452 4 strength strength NOUN bam-1807 452 5 and and CCONJ bam-1807 452 6 endurance endurance NOUN bam-1807 452 7 training training NOUN bam-1807 452 8 : : PUNCT bam-1807 452 9 are be AUX bam-1807 452 10 they they PRON bam-1807 452 11 incompatible?appl incompatible?appl PROPN bam-1807 452 12 physiol physiol PROPN bam-1807 452 13 nutr nutr PROPN bam-1807 452 14 metab metab PROPN bam-1807 452 15 2009 2009 NUM bam-1807 452 16 ; ; PUNCT bam-1807 452 17 34 34 NUM bam-1807 452 18 : : SYM bam-1807 452 19 355–361 355–361 NUM bam-1807 452 20 . . PUNCT bam-1807 453 1 [ [ X bam-1807 453 2 37 37 NUM bam-1807 453 3 ] ] X bam-1807 453 4 hickson hickson PROPN bam-1807 453 5 rc rc PROPN bam-1807 453 6 . . PROPN bam-1807 453 7 interference interference NOUN bam-1807 453 8 of of ADP bam-1807 453 9 strength strength NOUN bam-1807 453 10 development development NOUN bam-1807 453 11 by by ADP bam-1807 453 12 simultaneously simultaneously ADV bam-1807 453 13 training training NOUN bam-1807 453 14 for for ADP bam-1807 453 15 strength strength NOUN bam-1807 453 16 and and CCONJ bam-1807 453 17 endurance endurance NOUN bam-1807 453 18 . . PUNCT bam-1807 454 1 eur eur PROPN bam-1807 454 2 . . PUNCT bam-1807 455 1 j. j. PROPN bam-1807 455 2 appl appl PROPN bam-1807 455 3 . . PUNCT bam-1807 455 4 physiol physiol PROPN bam-1807 455 5 . . PUNCT bam-1807 456 1 occup occup ADJ bam-1807 456 2 . . PUNCT bam-1807 457 1 physiol physiol PROPN bam-1807 457 2 . . PUNCT bam-1807 458 1 1980 1980 NUM bam-1807 458 2 ; ; PUNCT bam-1807 459 1 45 45 NUM bam-1807 459 2 : : PUNCT bam-1807 459 3 255–263 255–263 NUM bam-1807 459 4 . . PUNCT bam-1807 460 1 [ [ X bam-1807 460 2 38 38 NUM bam-1807 460 3 ] ] PUNCT bam-1807 460 4 hill hill PROPN bam-1807 460 5 m m PROPN bam-1807 460 6 , , PUNCT bam-1807 460 7 goldspink goldspink ADJ bam-1807 460 8 g. g. NOUN bam-1807 460 9 expression expression NOUN bam-1807 460 10 and and CCONJ bam-1807 460 11 splicing splicing NOUN bam-1807 460 12 of of ADP bam-1807 460 13 the the DET bam-1807 460 14 insulin insulin NOUN bam-1807 460 15 - - PUNCT bam-1807 460 16 like like ADJ bam-1807 460 17 growth growth NOUN bam-1807 460 18 factor factor NOUN bam-1807 460 19 gene gene NOUN bam-1807 460 20 in in ADP bam-1807 460 21 rodent rodent ADJ bam-1807 460 22 muscle muscle NOUN bam-1807 460 23 is be AUX bam-1807 460 24 associated associate VERB bam-1807 460 25 with with ADP bam-1807 460 26 muscle muscle NOUN bam-1807 460 27 satellite satellite NOUN bam-1807 460 28 ( ( PUNCT bam-1807 460 29 stem stem NOUN bam-1807 460 30 ) ) PUNCT bam-1807 460 31 cell cell NOUN bam-1807 460 32 activation activation NOUN bam-1807 460 33 following follow VERB bam-1807 460 34 local local ADJ bam-1807 460 35 tissue tissue NOUN bam-1807 460 36 damage damage NOUN bam-1807 460 37 . . PUNCT bam-1807 461 1 j. j. PROPN bam-1807 461 2 physiol physiol PROPN bam-1807 461 3 . . PUNCT bam-1807 462 1 2003 2003 NUM bam-1807 462 2 ; ; PUNCT bam-1807 462 3 549(pt 549(pt DET bam-1807 462 4 2):409 2):409 NOUN bam-1807 462 5 - - NOUN bam-1807 462 6 418 418 NUM bam-1807 462 7 . . PUNCT bam-1807 463 1 [ [ X bam-1807 463 2 39 39 NUM bam-1807 463 3 ] ] PUNCT bam-1807 463 4 hood hood NOUN bam-1807 463 5 da da NOUN bam-1807 463 6 , , PUNCT bam-1807 463 7 irrcher irrcher ADP bam-1807 463 8 i i PRON bam-1807 463 9 , , PUNCT bam-1807 463 10 ljubicic ljubicic PROPN bam-1807 463 11 v v PROPN bam-1807 463 12 , , PUNCT bam-1807 463 13 joseph joseph PROPN bam-1807 463 14 am be AUX bam-1807 463 15 . . PUNCT bam-1807 464 1 coordination coordination NOUN bam-1807 464 2 of of ADP bam-1807 464 3 metabolic metabolic NOUN bam-1807 464 4 plasticity plasticity NOUN bam-1807 464 5 in in ADP bam-1807 464 6 skeletal skeletal ADJ bam-1807 464 7 muscle muscle NOUN bam-1807 464 8 . . PUNCT bam-1807 465 1 j. j. PROPN bam-1807 465 2 exp exp PROPN bam-1807 465 3 . . PUNCT bam-1807 466 1 biol biol PROPN bam-1807 466 2 . . PUNCT bam-1807 467 1 2006 2006 NUM bam-1807 467 2 ; ; PUNCT bam-1807 467 3 209:2265 209:2265 NUM bam-1807 467 4 - - SYM bam-1807 467 5 2275 2275 NUM bam-1807 467 6 . . PUNCT bam-1807 468 1 [ [ X bam-1807 468 2 40 40 NUM bam-1807 468 3 ] ] X bam-1807 468 4 hood hood NOUN bam-1807 468 5 da da X bam-1807 468 6 . . PUNCT bam-1807 468 7 mechanisms mechanism NOUN bam-1807 468 8 of of ADP bam-1807 468 9 exercise exercise NOUN bam-1807 468 10 - - PUNCT bam-1807 468 11 induced induce VERB bam-1807 468 12 mitochondrial mitochondrial ADJ bam-1807 468 13 biogenesis biogenesis NOUN bam-1807 468 14 in in ADP bam-1807 468 15 skeletal skeletal ADJ bam-1807 468 16 muscle muscle NOUN bam-1807 468 17 . . PUNCT bam-1807 469 1 appl appl PROPN bam-1807 469 2 physiol physiol PROPN bam-1807 469 3 nutr nutr PROPN bam-1807 469 4 metab metab PROPN bam-1807 469 5 . . PUNCT bam-1807 470 1 2009;34:465 2009;34:465 NUM bam-1807 470 2 - - PUNCT bam-1807 470 3 472 472 NUM bam-1807 470 4 . . PUNCT bam-1807 471 1 [ [ X bam-1807 471 2 41 41 NUM bam-1807 471 3 ] ] X bam-1807 471 4 hornberger hornberger NOUN bam-1807 471 5 ta ta PROPN bam-1807 471 6 , , PUNCT bam-1807 471 7 sukhija sukhija VERB bam-1807 471 8 kb kb PROPN bam-1807 471 9 , , PUNCT bam-1807 471 10 chien chien PROPN bam-1807 471 11 s. s. PROPN bam-1807 471 12 regulation regulation PROPN bam-1807 471 13 of of ADP bam-1807 471 14 mtor mtor NOUN bam-1807 471 15 by by ADP bam-1807 471 16 mechanically mechanically ADV bam-1807 471 17 induced induced ADJ bam-1807 471 18 signaling signal VERB bam-1807 471 19 events event NOUN bam-1807 471 20 in in ADP bam-1807 471 21 skeletal skeletal ADJ bam-1807 471 22 muscle muscle NOUN bam-1807 471 23 . . PUNCT bam-1807 472 1 cell cell NOUN bam-1807 472 2 cycle cycle NOUN bam-1807 472 3 2006 2006 NUM bam-1807 472 4 ; ; PUNCT bam-1807 472 5 13:1391–1396 13:1391–1396 NUM bam-1807 472 6 . . PUNCT bam-1807 473 1 [ [ X bam-1807 473 2 42 42 NUM bam-1807 473 3 ] ] X bam-1807 473 4 hornberger hornberger NOUN bam-1807 473 5 ta ta PROPN bam-1807 473 6 , , PUNCT bam-1807 473 7 chien chien PROPN bam-1807 473 8 s. s. PROPN bam-1807 473 9 mechanical mechanical PROPN bam-1807 473 10 stimuli stimulus NOUN bam-1807 473 11 and and CCONJ bam-1807 473 12 nutrients nutrient NOUN bam-1807 473 13 regulate regulate VERB bam-1807 473 14 rapamycin rapamycin NOUN bam-1807 473 15 - - PUNCT bam-1807 473 16 sensitive sensitive ADJ bam-1807 473 17 signaling signal VERB bam-1807 473 18 through through ADP bam-1807 473 19 distinct distinct ADJ bam-1807 473 20 mechanisms mechanism NOUN bam-1807 473 21 in in ADP bam-1807 473 22 skeletal skeletal ADJ bam-1807 473 23 muscle muscle NOUN bam-1807 473 24 . . PUNCT bam-1807 474 1 j j PROPN bam-1807 474 2 cell cell PROPN bam-1807 474 3 biochem biochem PROPN bam-1807 474 4 . . PUNCT bam-1807 475 1 2006 2006 NUM bam-1807 475 2 ; ; PUNCT bam-1807 475 3 97:1207 97:1207 NOUN bam-1807 475 4 - - SYM bam-1807 475 5 1216 1216 NUM bam-1807 475 6 . . PUNCT bam-1807 476 1 [ [ X bam-1807 476 2 43 43 NUM bam-1807 476 3 ] ] X bam-1807 476 4 horowitz horowitz PROPN bam-1807 476 5 jf jf PROPN bam-1807 476 6 , , PUNCT bam-1807 476 7 leone leone PROPN bam-1807 476 8 tc tc PROPN bam-1807 476 9 , , PUNCT bam-1807 476 10 feng feng PROPN bam-1807 476 11 w w PROPN bam-1807 476 12 , , PUNCT bam-1807 476 13 kelly kelly PROPN bam-1807 476 14 dp dp PROPN bam-1807 476 15 , , PUNCT bam-1807 476 16 klein klein PROPN bam-1807 476 17 s. s. PROPN bam-1807 476 18 effect effect PROPN bam-1807 476 19 of of ADP bam-1807 476 20 endurance endurance NOUN bam-1807 476 21 training training NOUN bam-1807 476 22 on on ADP bam-1807 476 23 lipid lipid ADJ bam-1807 476 24 metabolism metabolism NOUN bam-1807 476 25 in in ADP bam-1807 476 26 women woman NOUN bam-1807 476 27 : : PUNCT bam-1807 476 28 a a DET bam-1807 476 29 potential potential ADJ bam-1807 476 30 role role NOUN bam-1807 476 31 for for ADP bam-1807 476 32 pparalpha pparalpha NOUN bam-1807 476 33 in in ADP bam-1807 476 34 the the DET bam-1807 476 35 metabolic metabolic NOUN bam-1807 476 36 response response NOUN bam-1807 476 37 to to ADP bam-1807 476 38 the the DET bam-1807 476 39 exercised exercise VERB bam-1807 476 40 skeletal skeletal ADJ bam-1807 476 41 muscle muscle NOUN bam-1807 476 42 european european PROPN bam-1807 476 43 journal journal PROPN bam-1807 476 44 translational translational ADJ bam-1807 476 45 myology myology NOUN bam-1807 476 46 myology myology NOUN bam-1807 476 47 reviews review VERB bam-1807 476 48 20 20 NUM bam-1807 476 49 ( ( PUNCT bam-1807 476 50 3 3 NUM bam-1807 476 51 ): ): PUNCT bam-1807 476 52 105 105 NUM bam-1807 476 53 - - SYM bam-1807 476 54 120 120 NUM bam-1807 476 55 , , PUNCT bam-1807 476 56 2010 2010 NUM bam-1807 476 57 117 117 NUM bam-1807 476 58 training training NOUN bam-1807 476 59 . . PUNCT bam-1807 476 60 am be AUX bam-1807 476 61 . . PUNCT bam-1807 477 1 j. j. PROPN bam-1807 477 2 physiol physiol PROPN bam-1807 477 3 . . PUNCT bam-1807 478 1 endocrinol endocrinol NOUN bam-1807 478 2 . . PUNCT bam-1807 479 1 metab metab PROPN bam-1807 479 2 . . PUNCT bam-1807 480 1 2000;279 2000;279 NUM bam-1807 480 2 : : PUNCT bam-1807 480 3 e348 e348 PROPN bam-1807 480 4 - - SYM bam-1807 480 5 e355 e355 PROPN bam-1807 480 6 . . PUNCT bam-1807 481 1 [ [ X bam-1807 481 2 44 44 NUM bam-1807 481 3 ] ] SYM bam-1807 481 4 howatson howatson NOUN bam-1807 481 5 g g NOUN bam-1807 481 6 , , PUNCT bam-1807 481 7 van van PROPN bam-1807 481 8 someren someren PROPN bam-1807 481 9 ka ka PROPN bam-1807 481 10 . . PUNCT bam-1807 482 1 the the DET bam-1807 482 2 prevention prevention NOUN bam-1807 482 3 and and CCONJ bam-1807 482 4 treatment treatment NOUN bam-1807 482 5 of of ADP bam-1807 482 6 exercise exercise NOUN bam-1807 482 7 - - PUNCT bam-1807 482 8 induced induce VERB bam-1807 482 9 muscle muscle NOUN bam-1807 482 10 damage damage NOUN bam-1807 482 11 . . PUNCT bam-1807 483 1 med med PROPN bam-1807 483 2 . . PROPN bam-1807 483 3 2008 2008 NUM bam-1807 483 4 ; ; PUNCT bam-1807 483 5 38:483 38:483 NUM bam-1807 483 6 - - SYM bam-1807 483 7 503 503 NUM bam-1807 483 8 . . PUNCT bam-1807 484 1 [ [ X bam-1807 484 2 45 45 NUM bam-1807 484 3 ] ] X bam-1807 484 4 ingber ingber NOUN bam-1807 484 5 de de X bam-1807 484 6 . . PUNCT bam-1807 484 7 cellular cellular ADJ bam-1807 484 8 mechanotransduction mechanotransduction NOUN bam-1807 484 9 : : PUNCT bam-1807 484 10 putting put VERB bam-1807 484 11 all all DET bam-1807 484 12 the the DET bam-1807 484 13 pieces piece NOUN bam-1807 484 14 together together ADV bam-1807 484 15 again again ADV bam-1807 484 16 . . PUNCT bam-1807 485 1 faseb faseb PROPN bam-1807 485 2 j.2006 j.2006 PROPN bam-1807 485 3 ; ; PUNCT bam-1807 485 4 20 20 NUM bam-1807 485 5 : : PUNCT bam-1807 485 6 811–827 811–827 NUM bam-1807 485 7 . . PUNCT bam-1807 486 1 [ [ X bam-1807 486 2 46 46 NUM bam-1807 486 3 ] ] X bam-1807 486 4 inoki inoki PROPN bam-1807 486 5 k k PROPN bam-1807 486 6 , , PUNCT bam-1807 486 7 zhu zhu PROPN bam-1807 486 8 t t PROPN bam-1807 486 9 , , PUNCT bam-1807 486 10 guan guan PROPN bam-1807 486 11 kl kl PROPN bam-1807 486 12 . . PUNCT bam-1807 487 1 tsc2 tsc2 PROPN bam-1807 487 2 mediates mediate NOUN bam-1807 487 3 cellular cellular ADJ bam-1807 487 4 energy energy NOUN bam-1807 487 5 response response NOUN bam-1807 487 6 to to PART bam-1807 487 7 control control VERB bam-1807 487 8 cell cell NOUN bam-1807 487 9 growth growth NOUN bam-1807 487 10 and and CCONJ bam-1807 487 11 survival survival NOUN bam-1807 487 12 . . PUNCT bam-1807 488 1 cell cell NOUN bam-1807 488 2 2003 2003 NUM bam-1807 488 3 ; ; PUNCT bam-1807 488 4 115:577–590 115:577–590 NUM bam-1807 488 5 . . PUNCT bam-1807 489 1 [ [ X bam-1807 489 2 47 47 NUM bam-1807 489 3 ] ] PUNCT bam-1807 489 4 irrcher irrcher ADP bam-1807 489 5 i i PROPN bam-1807 489 6 , , PUNCT bam-1807 489 7 ljubicic ljubicic PROPN bam-1807 489 8 v v ADP bam-1807 489 9 , , PUNCT bam-1807 489 10 hood hood NOUN bam-1807 489 11 da da NOUN bam-1807 489 12 . . PUNCT bam-1807 490 1 interactions interaction NOUN bam-1807 490 2 between between ADP bam-1807 490 3 ros ros PROPN bam-1807 490 4 and and CCONJ bam-1807 490 5 amp amp PROPN bam-1807 490 6 kinase kinase PROPN bam-1807 490 7 activity activity NOUN bam-1807 490 8 in in ADP bam-1807 490 9 the the DET bam-1807 490 10 regulation regulation NOUN bam-1807 490 11 of of ADP bam-1807 490 12 pgc-1alpha pgc-1alpha NOUN bam-1807 490 13 transcription transcription NOUN bam-1807 490 14 in in ADP bam-1807 490 15 skeletal skeletal ADJ bam-1807 490 16 muscle muscle NOUN bam-1807 490 17 cells cell NOUN bam-1807 490 18 . . PUNCT bam-1807 491 1 am be AUX bam-1807 491 2 . . PUNCT bam-1807 492 1 j. j. PROPN bam-1807 492 2 physiol physiol PROPN bam-1807 492 3 . . PUNCT bam-1807 493 1 cell cell NOUN bam-1807 493 2 physiol physiol PROPN bam-1807 493 3 . . PUNCT bam-1807 494 1 2009 2009 NUM bam-1807 494 2 ; ; PUNCT bam-1807 494 3 296 296 NUM bam-1807 494 4 : : PUNCT bam-1807 494 5 c116 c116 PROPN bam-1807 494 6 - - PUNCT bam-1807 494 7 c123 c123 PROPN bam-1807 494 8 . . PUNCT bam-1807 495 1 [ [ X bam-1807 495 2 48 48 NUM bam-1807 495 3 ] ] X bam-1807 495 4 jackson jackson PROPN bam-1807 495 5 mj mj PROPN bam-1807 495 6 , , PUNCT bam-1807 495 7 edwards edwards PROPN bam-1807 495 8 ht ht PROPN bam-1807 495 9 , , PUNCT bam-1807 495 10 symons symons PROPN bam-1807 495 11 mcr mcr PROPN bam-1807 495 12 . . PROPN bam-1807 495 13 electron electron PROPN bam-1807 495 14 spin spin NOUN bam-1807 495 15 resonance resonance NOUN bam-1807 495 16 studies study NOUN bam-1807 495 17 of of ADP bam-1807 495 18 intact intact ADJ bam-1807 495 19 mammalian mammalian ADJ bam-1807 495 20 skeletal skeletal ADJ bam-1807 495 21 muscle muscle NOUN bam-1807 495 22 . . PUNCT bam-1807 496 1 biochim biochim NOUN bam-1807 496 2 . . PUNCT bam-1807 497 1 biophys biophy NOUN bam-1807 497 2 . . PUNCT bam-1807 498 1 acta acta PROPN bam-1807 498 2 1985 1985 NUM bam-1807 498 3 ; ; PUNCT bam-1807 498 4 847:185 847:185 NOUN bam-1807 498 5 - - NOUN bam-1807 498 6 190 190 NUM bam-1807 498 7 . . PUNCT bam-1807 499 1 [ [ X bam-1807 499 2 49 49 NUM bam-1807 499 3 ] ] X bam-1807 499 4 james james PROPN bam-1807 499 5 de de PROPN bam-1807 499 6 , , PUNCT bam-1807 499 7 kraegen kraegen PROPN bam-1807 499 8 ew ew PROPN bam-1807 499 9 , , PUNCT bam-1807 499 10 chisholm chisholm PROPN bam-1807 499 11 dj dj PROPN bam-1807 499 12 . . PROPN bam-1807 499 13 effect effect NOUN bam-1807 499 14 of of ADP bam-1807 499 15 exercise exercise NOUN bam-1807 499 16 training training NOUN bam-1807 499 17 on on ADP bam-1807 499 18 whole whole ADJ bam-1807 499 19 - - PUNCT bam-1807 499 20 body body NOUN bam-1807 499 21 insulin insulin NOUN bam-1807 499 22 sensitivity sensitivity NOUN bam-1807 499 23 and and CCONJ bam-1807 499 24 responsiveness responsiveness NOUN bam-1807 499 25 . . PUNCT bam-1807 500 1 j. j. PROPN bam-1807 500 2 appl appl PROPN bam-1807 500 3 . . PUNCT bam-1807 500 4 physiol physiol PROPN bam-1807 500 5 . . PUNCT bam-1807 501 1 1984 1984 NUM bam-1807 501 2 ; ; PUNCT bam-1807 501 3 56:1217–1222 56:1217–1222 NUM bam-1807 501 4 . . PUNCT bam-1807 502 1 [ [ X bam-1807 502 2 50 50 NUM bam-1807 502 3 ] ] PUNCT bam-1807 502 4 jones jones PROPN bam-1807 502 5 da da PROPN bam-1807 502 6 , , PUNCT bam-1807 502 7 de de PROPN bam-1807 502 8 haan haan PROPN bam-1807 502 9 a a X bam-1807 502 10 , , PUNCT bam-1807 502 11 round round PROPN bam-1807 502 12 j j PROPN bam-1807 502 13 , , PUNCT bam-1807 502 14 skeletal skeletal ADJ bam-1807 502 15 muscle muscle NOUN bam-1807 502 16 -from -from ADJ bam-1807 502 17 molecules molecule NOUN bam-1807 502 18 to to ADP bam-1807 502 19 movement movement NOUN bam-1807 502 20 , , PUNCT bam-1807 502 21 2004 2004 NUM bam-1807 502 22 , , PUNCT bam-1807 502 23 churchill churchill PROPN bam-1807 502 24 livingstone livingstone PROPN bam-1807 502 25 publ publ PROPN bam-1807 502 26 . . PUNCT bam-1807 503 1 philadelphia philadelphia PROPN bam-1807 503 2 , , PUNCT bam-1807 503 3 pa pa PROPN bam-1807 503 4 . . PUNCT bam-1807 504 1 [ [ X bam-1807 504 2 51 51 NUM bam-1807 504 3 ] ] X bam-1807 504 4 kang kang PROPN bam-1807 504 5 c c PROPN bam-1807 504 6 , , PUNCT bam-1807 504 7 o'moore o'moore PROPN bam-1807 504 8 km km PROPN bam-1807 504 9 , , PUNCT bam-1807 504 10 dickman dickman PROPN bam-1807 504 11 jr jr PROPN bam-1807 504 12 , , PUNCT bam-1807 504 13 ji ji PROPN bam-1807 504 14 ll ll AUX bam-1807 504 15 . . PUNCT bam-1807 505 1 exercise exercise NOUN bam-1807 505 2 activation activation NOUN bam-1807 505 3 of of ADP bam-1807 505 4 muscle muscle NOUN bam-1807 505 5 peroxisome peroxisome VERB bam-1807 505 6 proliferator proliferator NOUN bam-1807 505 7 - - PUNCT bam-1807 505 8 activated activate VERB bam-1807 505 9 receptor receptor NOUN bam-1807 505 10 - - PUNCT bam-1807 505 11 gamma gamma NOUN bam-1807 505 12 coactivator-1alpha coactivator-1alpha PROPN bam-1807 505 13 signaling signal VERB bam-1807 505 14 is be AUX bam-1807 505 15 redox redox ADJ bam-1807 505 16 sensitive sensitive ADJ bam-1807 505 17 . . PUNCT bam-1807 506 1 free free ADJ bam-1807 506 2 radic radic ADJ bam-1807 506 3 biol biol PROPN bam-1807 506 4 med me VERB bam-1807 506 5 . . PUNCT bam-1807 506 6 2009 2009 NUM bam-1807 506 7 ; ; PUNCT bam-1807 506 8 47:1394 47:1394 X bam-1807 506 9 - - SYM bam-1807 506 10 1400 1400 NUM bam-1807 506 11 . . PUNCT bam-1807 507 1 [ [ X bam-1807 507 2 52 52 NUM bam-1807 507 3 ] ] X bam-1807 507 4 kelley kelley PROPN bam-1807 507 5 de de PROPN bam-1807 507 6 , , PUNCT bam-1807 507 7 goodpaster goodpaster ADJ bam-1807 507 8 bh bh PROPN bam-1807 507 9 . . PROPN bam-1807 507 10 effects effect NOUN bam-1807 507 11 of of ADP bam-1807 507 12 physical physical ADJ bam-1807 507 13 activity activity NOUN bam-1807 507 14 on on ADP bam-1807 507 15 insulin insulin NOUN bam-1807 507 16 action action NOUN bam-1807 507 17 and and CCONJ bam-1807 507 18 glucose glucose NOUN bam-1807 507 19 tolerance tolerance NOUN bam-1807 507 20 in in ADP bam-1807 507 21 obesity obesity NOUN bam-1807 507 22 . . PUNCT bam-1807 508 1 med med PROPN bam-1807 508 2 . . PUNCT bam-1807 509 1 sci sci PROPN bam-1807 509 2 . . PUNCT bam-1807 509 3 sports sport NOUN bam-1807 509 4 exerc exerc PROPN bam-1807 509 5 . . PUNCT bam-1807 509 6 1999 1999 NUM bam-1807 509 7 ; ; PUNCT bam-1807 509 8 31 31 NUM bam-1807 509 9 : : PUNCT bam-1807 509 10 s619 s619 NUM bam-1807 509 11 – – PUNCT bam-1807 509 12 s623 s623 NUM bam-1807 509 13 . . PUNCT bam-1807 510 1 [ [ X bam-1807 510 2 53 53 NUM bam-1807 510 3 ] ] X bam-1807 510 4 kline kline PROPN bam-1807 510 5 wo will AUX bam-1807 510 6 , , PUNCT bam-1807 510 7 panaro panaro VERB bam-1807 510 8 fj fj PROPN bam-1807 510 9 , , PUNCT bam-1807 510 10 yang yang PROPN bam-1807 510 11 h h PROPN bam-1807 510 12 , , PUNCT bam-1807 510 13 bodine bodine PROPN bam-1807 510 14 sc sc PROPN bam-1807 510 15 . . PROPN bam-1807 510 16 rapamycin rapamycin PROPN bam-1807 510 17 inhibits inhibit VERB bam-1807 510 18 the the DET bam-1807 510 19 growth growth NOUN bam-1807 510 20 and and CCONJ bam-1807 510 21 musclesparing musclesparing NOUN bam-1807 510 22 effects effect NOUN bam-1807 510 23 of of ADP bam-1807 510 24 clenbuterol clenbuterol PROPN bam-1807 510 25 . . PUNCT bam-1807 511 1 j. j. PROPN bam-1807 511 2 appl appl PROPN bam-1807 511 3 . . PUNCT bam-1807 511 4 physiol physiol PROPN bam-1807 511 5 . . PUNCT bam-1807 512 1 2007;102:740 2007;102:740 NUM bam-1807 512 2 - - SYM bam-1807 512 3 747 747 NUM bam-1807 512 4 . . PUNCT bam-1807 513 1 [ [ X bam-1807 513 2 54 54 NUM bam-1807 513 3 ] ] PUNCT bam-1807 513 4 koopman koopman PROPN bam-1807 513 5 wj wj PROPN bam-1807 513 6 , , PUNCT bam-1807 513 7 verkaart verkaart NOUN bam-1807 513 8 s s PROPN bam-1807 513 9 , , PUNCT bam-1807 513 10 visch visch PROPN bam-1807 513 11 hj hj PROPN bam-1807 513 12 , , PUNCT bam-1807 513 13 van van PROPN bam-1807 513 14 der der PROPN bam-1807 513 15 westhuizen westhuizen PROPN bam-1807 513 16 fh fh PROPN bam-1807 513 17 , , PUNCT bam-1807 513 18 murphy murphy PROPN bam-1807 513 19 mp mp PROPN bam-1807 513 20 . . PROPN bam-1807 513 21 , , PUNCT bam-1807 513 22 van van PROPN bam-1807 513 23 den den PROPN bam-1807 513 24 heuvel heuvel PROPN bam-1807 513 25 lw lw PROPN bam-1807 513 26 , , PUNCT bam-1807 513 27 smeitink smeitink PROPN bam-1807 513 28 ja ja PROPN bam-1807 513 29 , , PUNCT bam-1807 513 30 willems willems PROPN bam-1807 513 31 ph ph VERB bam-1807 513 32 . . PROPN bam-1807 513 33 inhibition inhibition NOUN bam-1807 513 34 of of ADP bam-1807 513 35 complex complex ADJ bam-1807 513 36 i i PRON bam-1807 513 37 of of ADP bam-1807 513 38 the the DET bam-1807 513 39 electron electron NOUN bam-1807 513 40 transport transport NOUN bam-1807 513 41 chain chain NOUN bam-1807 513 42 causes cause VERB bam-1807 513 43 o2 o2 ADJ bam-1807 513 44 - - PUNCT bam-1807 513 45 mediated mediate VERB bam-1807 513 46 mitochondrial mitochondrial ADJ bam-1807 513 47 outgrowth outgrowth NOUN bam-1807 513 48 . . PUNCT bam-1807 514 1 am be AUX bam-1807 514 2 . . PUNCT bam-1807 515 1 j. j. PROPN bam-1807 515 2 physiol physiol PROPN bam-1807 515 3 . . PUNCT bam-1807 516 1 2005 2005 NUM bam-1807 516 2 ; ; PUNCT bam-1807 516 3 288 288 NUM bam-1807 516 4 , , PUNCT bam-1807 516 5 c1440 c1440 NOUN bam-1807 516 6 - - PUNCT bam-1807 516 7 c1450 c1450 NOUN bam-1807 516 8 . . PUNCT bam-1807 517 1 [ [ X bam-1807 517 2 55 55 NUM bam-1807 517 3 ] ] SYM bam-1807 517 4 kosek kosek NOUN bam-1807 517 5 dj dj PROPN bam-1807 517 6 , , PUNCT bam-1807 517 7 bamman bamman NOUN bam-1807 517 8 mm mm PROPN bam-1807 517 9 . . PUNCT bam-1807 517 10 modulation modulation NOUN bam-1807 517 11 of of ADP bam-1807 517 12 the the DET bam-1807 517 13 dystrophin dystrophin NOUN bam-1807 517 14 - - PUNCT bam-1807 517 15 associated associate VERB bam-1807 517 16 protein protein NOUN bam-1807 517 17 complex complex NOUN bam-1807 517 18 in in ADP bam-1807 517 19 response response NOUN bam-1807 517 20 to to ADP bam-1807 517 21 resistance resistance NOUN bam-1807 517 22 training training NOUN bam-1807 517 23 in in ADP bam-1807 517 24 young young ADJ bam-1807 517 25 and and CCONJ bam-1807 517 26 older old ADJ bam-1807 517 27 men man NOUN bam-1807 517 28 . . PUNCT bam-1807 518 1 j. j. PROPN bam-1807 518 2 appl appl PROPN bam-1807 518 3 . . PUNCT bam-1807 518 4 physiol physiol PROPN bam-1807 518 5 . . PUNCT bam-1807 519 1 2008 2008 NUM bam-1807 519 2 ; ; PUNCT bam-1807 519 3 104:14761484 104:14761484 X bam-1807 519 4 . . PUNCT bam-1807 520 1 [ [ X bam-1807 520 2 56 56 NUM bam-1807 520 3 ] ] X bam-1807 520 4 kramer kramer PROPN bam-1807 520 5 hf hf PROPN bam-1807 520 6 , , PUNCT bam-1807 520 7 taylor taylor PROPN bam-1807 520 8 eb eb PROPN bam-1807 520 9 , , PUNCT bam-1807 520 10 witczak witczak NOUN bam-1807 520 11 ca can AUX bam-1807 520 12 , , PUNCT bam-1807 520 13 fujii fujii PROPN bam-1807 520 14 n n CCONJ bam-1807 520 15 , , PUNCT bam-1807 520 16 hirshman hirshman NOUN bam-1807 520 17 mf mf PROPN bam-1807 520 18 , , PUNCT bam-1807 520 19 goodyear goodyear PROPN bam-1807 520 20 lj lj PROPN bam-1807 520 21 . . PUNCT bam-1807 521 1 calmodulinbinding calmodulinbinde VERB bam-1807 521 2 domain domain NOUN bam-1807 521 3 of of ADP bam-1807 521 4 as160 as160 PROPN bam-1807 521 5 regulates regulate VERB bam-1807 521 6 contraction contraction NOUN bam-1807 521 7 but but CCONJ bam-1807 521 8 not not PART bam-1807 521 9 insulin insulin NOUN bam-1807 521 10 - - PUNCT bam-1807 521 11 stimulated stimulate VERB bam-1807 521 12 glucose glucose NOUN bam-1807 521 13 uptake uptake NOUN bam-1807 521 14 in in ADP bam-1807 521 15 skeletal skeletal ADJ bam-1807 521 16 muscle muscle NOUN bam-1807 521 17 . . PUNCT bam-1807 522 1 diabetes diabetes NOUN bam-1807 522 2 . . PUNCT bam-1807 523 1 2007 2007 NUM bam-1807 523 2 ; ; PUNCT bam-1807 523 3 56:2854 56:2854 NUM bam-1807 523 4 - - SYM bam-1807 523 5 2862 2862 NUM bam-1807 523 6 . . PUNCT bam-1807 524 1 [ [ X bam-1807 524 2 57 57 NUM bam-1807 524 3 ] ] X bam-1807 524 4 kraus kraus PROPN bam-1807 524 5 rm rm PROPN bam-1807 524 6 , , PUNCT bam-1807 524 7 stallings stallings PROPN bam-1807 524 8 hw hw PROPN bam-1807 524 9 3rd 3rd NOUN bam-1807 524 10 , , PUNCT bam-1807 524 11 yeager yeager PROPN bam-1807 524 12 rc rc PROPN bam-1807 524 13 , , PUNCT bam-1807 524 14 gavin gavin PROPN bam-1807 524 15 tp tp PROPN bam-1807 524 16 . . PUNCT bam-1807 524 17 circulating circulate VERB bam-1807 524 18 plasma plasma NOUN bam-1807 524 19 vegf vegf PROPN bam-1807 524 20 response response NOUN bam-1807 524 21 to to PART bam-1807 524 22 exercise exercise VERB bam-1807 524 23 in in ADP bam-1807 524 24 sedentary sedentary ADJ bam-1807 524 25 and and CCONJ bam-1807 524 26 endurance endurance NOUN bam-1807 524 27 - - PUNCT bam-1807 524 28 trained train VERB bam-1807 524 29 men man NOUN bam-1807 524 30 . . PUNCT bam-1807 525 1 j. j. PROPN bam-1807 525 2 appl appl PROPN bam-1807 525 3 . . PUNCT bam-1807 525 4 physiol physiol PROPN bam-1807 525 5 . . PUNCT bam-1807 526 1 2004 2004 NUM bam-1807 526 2 ; ; PUNCT bam-1807 526 3 96:1445 96:1445 X bam-1807 526 4 - - SYM bam-1807 526 5 1450 1450 NUM bam-1807 526 6 . . PUNCT bam-1807 527 1 [ [ X bam-1807 527 2 58 58 NUM bam-1807 527 3 ] ] X bam-1807 527 4 lamb lamb PROPN bam-1807 527 5 gd gd PROPN bam-1807 527 6 . . PUNCT bam-1807 528 1 mechanisms mechanism NOUN bam-1807 528 2 of of ADP bam-1807 528 3 excitationcontraction excitationcontraction NOUN bam-1807 528 4 uncoupling uncouple VERB bam-1807 528 5 relevant relevant ADJ bam-1807 528 6 to to ADP bam-1807 528 7 activityinduced activityinduce VERB bam-1807 528 8 muscle muscle NOUN bam-1807 528 9 fatigue fatigue NOUN bam-1807 528 10 . . PUNCT bam-1807 529 1 appl appl PROPN bam-1807 529 2 . . PUNCT bam-1807 529 3 physiol physiol PROPN bam-1807 529 4 . . PUNCT bam-1807 530 1 nutr nutr PROPN bam-1807 530 2 . . PUNCT bam-1807 530 3 metab metab PROPN bam-1807 530 4 . . PUNCT bam-1807 531 1 2009 2009 NUM bam-1807 531 2 ; ; PUNCT bam-1807 531 3 34:368 34:368 NUM bam-1807 531 4 - - SYM bam-1807 531 5 372 372 NUM bam-1807 531 6 . . PUNCT bam-1807 532 1 [ [ X bam-1807 532 2 59 59 NUM bam-1807 532 3 ] ] X bam-1807 532 4 lange lange NOUN bam-1807 532 5 s s PROPN bam-1807 532 6 , , PUNCT bam-1807 532 7 ehler ehler NOUN bam-1807 532 8 e e NOUN bam-1807 532 9 , , PUNCT bam-1807 532 10 gautel gautel NOUN bam-1807 532 11 m. m. NOUN bam-1807 532 12 from from ADP bam-1807 532 13 a a PRON bam-1807 532 14 to to ADP bam-1807 532 15 z z NOUN bam-1807 532 16 and and CCONJ bam-1807 532 17 back back ADV bam-1807 532 18 ? ? PUNCT bam-1807 533 1 multicompartment multicompartment ADJ bam-1807 533 2 proteins protein NOUN bam-1807 533 3 in in ADP bam-1807 533 4 the the DET bam-1807 533 5 sarcomere sarcomere NOUN bam-1807 533 6 . . PUNCT bam-1807 534 1 trends trend NOUN bam-1807 534 2 cell cell NOUN bam-1807 534 3 biol biol NOUN bam-1807 534 4 . . PUNCT bam-1807 535 1 2006 2006 NUM bam-1807 535 2 ; ; PUNCT bam-1807 535 3 16:11 16:11 NUM bam-1807 535 4 - - SYM bam-1807 535 5 18 18 NUM bam-1807 535 6 . . PUNCT bam-1807 536 1 [ [ X bam-1807 536 2 60 60 NUM bam-1807 536 3 ] ] X bam-1807 536 4 laughlin laughlin PROPN bam-1807 536 5 mh mh PROPN bam-1807 536 6 , , PUNCT bam-1807 536 7 roseguini roseguini PROPN bam-1807 536 8 b. b. PROPN bam-1807 536 9 mechanisms mechanism NOUN bam-1807 536 10 for for ADP bam-1807 536 11 exercise exercise NOUN bam-1807 536 12 training training NOUN bam-1807 536 13 - - PUNCT bam-1807 536 14 induced induce VERB bam-1807 536 15 increases increase NOUN bam-1807 536 16 in in ADP bam-1807 536 17 skeletal skeletal ADJ bam-1807 536 18 muscle muscle NOUN bam-1807 536 19 blood blood NOUN bam-1807 536 20 flow flow NOUN bam-1807 536 21 capacity capacity NOUN bam-1807 536 22 : : PUNCT bam-1807 536 23 differences difference NOUN bam-1807 536 24 with with ADP bam-1807 536 25 interval interval NOUN bam-1807 536 26 sprint sprint NOUN bam-1807 536 27 training training NOUN bam-1807 536 28 versus versus ADP bam-1807 536 29 aerobic aerobic ADJ bam-1807 536 30 endurance endurance NOUN bam-1807 536 31 training training NOUN bam-1807 536 32 . . PUNCT bam-1807 537 1 j. j. PROPN bam-1807 537 2 physiol physiol PROPN bam-1807 537 3 . . PUNCT bam-1807 538 1 pharmacol pharmacol PROPN bam-1807 538 2 . . PROPN bam-1807 538 3 2008 2008 NUM bam-1807 538 4 ; ; PUNCT bam-1807 538 5 59:71 59:71 NUM bam-1807 538 6 - - SYM bam-1807 538 7 88 88 NUM bam-1807 538 8 . . PUNCT bam-1807 539 1 [ [ X bam-1807 539 2 61 61 NUM bam-1807 539 3 ] ] X bam-1807 539 4 laughlin laughlin PROPN bam-1807 539 5 mh mh PROPN bam-1807 539 6 , , PUNCT bam-1807 539 7 roseguini roseguini PROPN bam-1807 539 8 b. b. PROPN bam-1807 539 9 mechanisms mechanism NOUN bam-1807 539 10 for for ADP bam-1807 539 11 exercise exercise NOUN bam-1807 539 12 training training NOUN bam-1807 539 13 - - PUNCT bam-1807 539 14 induced induce VERB bam-1807 539 15 increases increase NOUN bam-1807 539 16 in in ADP bam-1807 539 17 skeletal skeletal ADJ bam-1807 539 18 muscle muscle NOUN bam-1807 539 19 blood blood NOUN bam-1807 539 20 flow flow NOUN bam-1807 539 21 capacity capacity NOUN bam-1807 539 22 : : PUNCT bam-1807 539 23 differences difference NOUN bam-1807 539 24 with with ADP bam-1807 539 25 interval interval NOUN bam-1807 539 26 sprint sprint NOUN bam-1807 539 27 training training NOUN bam-1807 539 28 versus versus ADP bam-1807 539 29 aerobic aerobic ADJ bam-1807 539 30 endurance endurance NOUN bam-1807 539 31 training training NOUN bam-1807 539 32 . . PUNCT bam-1807 540 1 j. j. PROPN bam-1807 540 2 physiol physiol PROPN bam-1807 540 3 . . PUNCT bam-1807 541 1 pharmacol pharmacol PROPN bam-1807 541 2 . . PROPN bam-1807 541 3 2008 2008 NUM bam-1807 541 4 ; ; PUNCT bam-1807 541 5 59:71 59:71 NUM bam-1807 541 6 - - SYM bam-1807 541 7 88 88 NUM bam-1807 541 8 . . PUNCT bam-1807 542 1 [ [ X bam-1807 542 2 62 62 NUM bam-1807 542 3 ] ] X bam-1807 542 4 lee lee PROPN bam-1807 542 5 i i PROPN bam-1807 542 6 m m PROPN bam-1807 542 7 , , PUNCT bam-1807 542 8 paffenbarger paffenbarger PROPN bam-1807 542 9 jr jr PROPN bam-1807 542 10 rs rs PROPN bam-1807 542 11 . . PUNCT bam-1807 543 1 associations association NOUN bam-1807 543 2 of of ADP bam-1807 543 3 light light ADJ bam-1807 543 4 , , PUNCT bam-1807 543 5 moderate moderate ADJ bam-1807 543 6 , , PUNCT bam-1807 543 7 and and CCONJ bam-1807 543 8 vigorous vigorous ADJ bam-1807 543 9 intensity intensity NOUN bam-1807 543 10 physical physical ADJ bam-1807 543 11 activity activity NOUN bam-1807 543 12 with with ADP bam-1807 543 13 longevity longevity NOUN bam-1807 543 14 . . PUNCT bam-1807 544 1 am be AUX bam-1807 544 2 . . PUNCT bam-1807 545 1 j. j. PROPN bam-1807 545 2 epidem epidem PROPN bam-1807 545 3 . . PUNCT bam-1807 546 1 2000 2000 NUM bam-1807 546 2 ; ; PUNCT bam-1807 546 3 151 151 NUM bam-1807 546 4 : : PUNCT bam-1807 547 1 293–299 293–299 NUM bam-1807 547 2 [ [ PUNCT bam-1807 547 3 63 63 NUM bam-1807 547 4 ] ] PUNCT bam-1807 547 5 lieber lieber PROPN bam-1807 547 6 rl rl PROPN bam-1807 547 7 , , PUNCT bam-1807 547 8 skeletal skeletal ADJ bam-1807 547 9 muscle muscle NOUN bam-1807 547 10 structure structure NOUN bam-1807 547 11 , , PUNCT bam-1807 547 12 function function NOUN bam-1807 547 13 , , PUNCT bam-1807 547 14 and and CCONJ bam-1807 547 15 plasticity plasticity NOUN bam-1807 547 16 2009 2009 NUM bam-1807 547 17 , , PUNCT bam-1807 547 18 lippincott lippincott PROPN bam-1807 547 19 williams williams PROPN bam-1807 547 20 and and CCONJ bam-1807 547 21 wilkins wilkins PROPN bam-1807 547 22 publ publ PROPN bam-1807 547 23 . . PROPN bam-1807 547 24 , , PUNCT bam-1807 547 25 philadelphia philadelphia PROPN bam-1807 547 26 , , PUNCT bam-1807 547 27 pa pa PROPN bam-1807 547 28 . . PUNCT bam-1807 548 1 [ [ X bam-1807 548 2 64 64 NUM bam-1807 548 3 ] ] X bam-1807 548 4 lin lin PROPN bam-1807 548 5 j j PROPN bam-1807 548 6 , , PUNCT bam-1807 548 7 wu wu PROPN bam-1807 548 8 h h PROPN bam-1807 548 9 , , PUNCT bam-1807 548 10 tarr tarr PROPN bam-1807 548 11 pt pt PROPN bam-1807 548 12 , , PUNCT bam-1807 548 13 zhang zhang PROPN bam-1807 548 14 cy cy PROPN bam-1807 548 15 , , PUNCT bam-1807 548 16 wu wu PROPN bam-1807 548 17 z z PROPN bam-1807 548 18 , , PUNCT bam-1807 548 19 boss boss NOUN bam-1807 548 20 o o NOUN bam-1807 548 21 , , PUNCT bam-1807 548 22 michael michael PROPN bam-1807 548 23 lf lf PROPN bam-1807 548 24 , , PUNCT bam-1807 548 25 puigserver puigserver PROPN bam-1807 548 26 p p X bam-1807 548 27 , , PUNCT bam-1807 548 28 isotani isotani PROPN bam-1807 548 29 e e PROPN bam-1807 548 30 , , PUNCT bam-1807 548 31 olson olson PROPN bam-1807 548 32 en en PROPN bam-1807 548 33 , , PUNCT bam-1807 548 34 lowell lowell PROPN bam-1807 548 35 bb bb PROPN bam-1807 548 36 , , PUNCT bam-1807 548 37 bassel bassel NOUN bam-1807 548 38 - - PUNCT bam-1807 548 39 duby duby PROPN bam-1807 548 40 r r PROPN bam-1807 548 41 , , PUNCT bam-1807 548 42 spiegelman spiegelman NOUN bam-1807 548 43 bm bm PROPN bam-1807 548 44 . . PUNCT bam-1807 548 45 transcriptional transcriptional ADJ bam-1807 548 46 co co NOUN bam-1807 548 47 - - NOUN bam-1807 548 48 activator activator NOUN bam-1807 548 49 pgc-1 pgc-1 NOUN bam-1807 548 50 alpha alpha NOUN bam-1807 548 51 drives drive VERB bam-1807 548 52 the the DET bam-1807 548 53 formation formation NOUN bam-1807 548 54 of of ADP bam-1807 548 55 slow slow ADJ bam-1807 548 56 - - PUNCT bam-1807 548 57 twitch twitch NOUN bam-1807 548 58 muscle muscle NOUN bam-1807 548 59 fibres fibre NOUN bam-1807 548 60 . . PUNCT bam-1807 549 1 nature nature NOUN bam-1807 549 2 2002 2002 NUM bam-1807 549 3 ; ; PUNCT bam-1807 549 4 418:797–801 418:797–801 NUM bam-1807 549 5 . . PUNCT bam-1807 550 1 [ [ X bam-1807 550 2 65 65 NUM bam-1807 550 3 ] ] X bam-1807 550 4 lundby lundby PROPN bam-1807 550 5 c c PROPN bam-1807 550 6 , , PUNCT bam-1807 550 7 calbet calbet PROPN bam-1807 550 8 ja ja PROPN bam-1807 550 9 , , PUNCT bam-1807 550 10 robach robach VERB bam-1807 550 11 p. p. NOUN bam-1807 551 1 the the DET bam-1807 551 2 response response NOUN bam-1807 551 3 of of ADP bam-1807 551 4 human human ADJ bam-1807 551 5 skeletal skeletal ADJ bam-1807 551 6 muscle muscle NOUN bam-1807 551 7 tissue tissue NOUN bam-1807 551 8 to to PART bam-1807 551 9 hypoxia hypoxia VERB bam-1807 551 10 . . PUNCT bam-1807 552 1 cell cell NOUN bam-1807 552 2 mol mol ADP bam-1807 552 3 life life PROPN bam-1807 552 4 sci sci PROPN bam-1807 552 5 . . PROPN bam-1807 552 6 2009 2009 NUM bam-1807 552 7 ; ; PUNCT bam-1807 552 8 66:3615 66:3615 NOUN bam-1807 552 9 - - SYM bam-1807 552 10 3623 3623 NUM bam-1807 552 11 . . PUNCT bam-1807 553 1 [ [ X bam-1807 553 2 66 66 NUM bam-1807 553 3 ] ] PUNCT bam-1807 553 4 luquet luquet PROPN bam-1807 553 5 s s PROPN bam-1807 553 6 , , PUNCT bam-1807 553 7 lopez lopez NOUN bam-1807 553 8 - - PUNCT bam-1807 553 9 soriano soriano PROPN bam-1807 553 10 j j PROPN bam-1807 553 11 , , PUNCT bam-1807 553 12 holst holst NOUN bam-1807 553 13 d d NOUN bam-1807 553 14 , , PUNCT bam-1807 553 15 fredenrich fredenrich PROPN bam-1807 553 16 a a PRON bam-1807 553 17 , , PUNCT bam-1807 553 18 melki melki PROPN bam-1807 553 19 j j PROPN bam-1807 553 20 , , PUNCT bam-1807 553 21 rassoulzadegan rassoulzadegan VERB bam-1807 553 22 m m PROPN bam-1807 553 23 , , PUNCT bam-1807 553 24 grimaldi grimaldi PROPN bam-1807 553 25 pa pa PROPN bam-1807 553 26 . . PROPN bam-1807 553 27 peroxisome peroxisome VERB bam-1807 553 28 proliferator proliferator PROPN bam-1807 553 29 - - PUNCT bam-1807 553 30 activated activate VERB bam-1807 553 31 receptor receptor NOUN bam-1807 553 32 delta delta NOUN bam-1807 553 33 controls control VERB bam-1807 553 34 muscle muscle NOUN bam-1807 553 35 development development NOUN bam-1807 553 36 and and CCONJ bam-1807 553 37 oxidative oxidative ADJ bam-1807 553 38 capability capability NOUN bam-1807 553 39 . . PUNCT bam-1807 554 1 faseb faseb PROPN bam-1807 554 2 j. j. PROPN bam-1807 554 3 2003 2003 NUM bam-1807 554 4 ; ; PUNCT bam-1807 554 5 17:2299–2301 17:2299–2301 NUM bam-1807 554 6 . . PUNCT bam-1807 555 1 [ [ X bam-1807 555 2 67 67 NUM bam-1807 555 3 ] ] X bam-1807 555 4 marini marini NOUN bam-1807 555 5 m. m. NOUN bam-1807 555 6 , , PUNCT bam-1807 555 7 lapalombella lapalombella NOUN bam-1807 555 8 r r NOUN bam-1807 555 9 , , PUNCT bam-1807 555 10 margonato margonato PROPN bam-1807 555 11 v v PROPN bam-1807 555 12 , , PUNCT bam-1807 555 13 ronchi ronchi PROPN bam-1807 555 14 r r PROPN bam-1807 555 15 , , PUNCT bam-1807 555 16 samaja samaja NOUN bam-1807 555 17 m m PROPN bam-1807 555 18 , , PUNCT bam-1807 555 19 scapin scapin NOUN bam-1807 555 20 c c PROPN bam-1807 555 21 , , PUNCT bam-1807 555 22 gorza gorza PROPN bam-1807 555 23 l l NOUN bam-1807 555 24 , , PUNCT bam-1807 555 25 maraldi maraldi PROPN bam-1807 555 26 t t PROPN bam-1807 555 27 , , PUNCT bam-1807 555 28 carinci carinci VERB bam-1807 555 29 p p NOUN bam-1807 555 30 , , PUNCT bam-1807 555 31 ventura ventura PROPN bam-1807 555 32 c c PROPN bam-1807 555 33 , , PUNCT bam-1807 555 34 veicsteinas veicsteinas PROPN bam-1807 555 35 a. a. NOUN bam-1807 555 36 mild mild ADJ bam-1807 555 37 exercise exercise NOUN bam-1807 555 38 training training NOUN bam-1807 555 39 , , PUNCT bam-1807 555 40 cardioprotection cardioprotection NOUN bam-1807 555 41 and and CCONJ bam-1807 555 42 stress stress NOUN bam-1807 555 43 gene gene NOUN bam-1807 555 44 profile profile NOUN bam-1807 555 45 . . PUNCT bam-1807 556 1 eur eur PROPN bam-1807 556 2 . . PUNCT bam-1807 557 1 j. j. PROPN bam-1807 557 2 appl appl PROPN bam-1807 557 3 . . PUNCT bam-1807 557 4 physiol physiol PROPN bam-1807 557 5 . . PUNCT bam-1807 558 1 2007 2007 NUM bam-1807 558 2 ; ; PUNCT bam-1807 558 3 99:503 99:503 NUM bam-1807 558 4 - - SYM bam-1807 558 5 510 510 NUM bam-1807 558 6 . . PUNCT bam-1807 559 1 [ [ X bam-1807 559 2 68 68 NUM bam-1807 559 3 ] ] X bam-1807 559 4 martin martin PROPN bam-1807 559 5 , , PUNCT bam-1807 559 6 d.e d.e PROPN bam-1807 559 7 . . PROPN bam-1807 559 8 , , PUNCT bam-1807 559 9 hall hall PROPN bam-1807 559 10 , , PUNCT bam-1807 559 11 m.n m.n PROPN bam-1807 559 12 . . PUNCT bam-1807 560 1 the the DET bam-1807 560 2 expanding expand VERB bam-1807 560 3 tor tor NOUN bam-1807 560 4 signaling signal VERB bam-1807 560 5 network network NOUN bam-1807 560 6 . . PUNCT bam-1807 561 1 curr curr PROPN bam-1807 561 2 . . PUNCT bam-1807 562 1 opin opin NOUN bam-1807 562 2 . . PUNCT bam-1807 563 1 cell cell NOUN bam-1807 563 2 biol biol PROPN bam-1807 563 3 . . PUNCT bam-1807 564 1 2005 2005 NUM bam-1807 564 2 ; ; PUNCT bam-1807 564 3 17:158–166 17:158–166 NUM bam-1807 564 4 . . PUNCT bam-1807 565 1 [ [ X bam-1807 565 2 69 69 NUM bam-1807 565 3 ] ] X bam-1807 565 4 mahoney mahoney PROPN bam-1807 565 5 dj dj PROPN bam-1807 565 6 , , PUNCT bam-1807 565 7 parise parise PROPN bam-1807 565 8 g g PROPN bam-1807 565 9 , , PUNCT bam-1807 565 10 melov melov PROPN bam-1807 565 11 s s PROPN bam-1807 565 12 , , PUNCT bam-1807 565 13 safdar safdar PROPN bam-1807 565 14 a a PROPN bam-1807 565 15 , , PUNCT bam-1807 565 16 tarnopolsky tarnopolsky PROPN bam-1807 565 17 ma ma PROPN bam-1807 565 18 . . PROPN bam-1807 566 1 analysis analysis NOUN bam-1807 566 2 of of ADP bam-1807 566 3 global global ADJ bam-1807 566 4 mrna mrna PROPN bam-1807 566 5 the the DET bam-1807 566 6 exercised exercise VERB bam-1807 566 7 skeletal skeletal ADJ bam-1807 566 8 muscle muscle NOUN bam-1807 566 9 european european PROPN bam-1807 566 10 journal journal PROPN bam-1807 566 11 translational translational ADJ bam-1807 566 12 myology myology NOUN bam-1807 566 13 myology myology NOUN bam-1807 566 14 reviews review VERB bam-1807 566 15 20 20 NUM bam-1807 566 16 ( ( PUNCT bam-1807 566 17 3 3 NUM bam-1807 566 18 ): ): PUNCT bam-1807 566 19 105 105 NUM bam-1807 566 20 - - SYM bam-1807 566 21 120 120 NUM bam-1807 566 22 , , PUNCT bam-1807 566 23 2010 2010 NUM bam-1807 566 24 118 118 NUM bam-1807 566 25 expression expression NOUN bam-1807 566 26 in in ADP bam-1807 566 27 human human ADJ bam-1807 566 28 skeletal skeletal ADJ bam-1807 566 29 muscle muscle NOUN bam-1807 566 30 during during ADP bam-1807 566 31 recovery recovery NOUN bam-1807 566 32 from from ADP bam-1807 566 33 endurance endurance ADJ bam-1807 566 34 exercise exercise NOUN bam-1807 566 35 . . PUNCT bam-1807 567 1 faseb faseb PROPN bam-1807 567 2 j. j. PROPN bam-1807 567 3 2005;19:1498–1500 2005;19:1498–1500 PROPN bam-1807 567 4 . . PUNCT bam-1807 568 1 [ [ X bam-1807 568 2 70 70 NUM bam-1807 568 3 ] ] X bam-1807 568 4 mcardle mcardle PROPN bam-1807 568 5 a a PROPN bam-1807 568 6 , , PUNCT bam-1807 568 7 pattwell pattwell NOUN bam-1807 568 8 d d PROPN bam-1807 568 9 , , PUNCT bam-1807 568 10 vasilaki vasilaki PROPN bam-1807 568 11 a a PRON bam-1807 568 12 , , PUNCT bam-1807 568 13 griffiths griffiths PROPN bam-1807 568 14 rd rd PROPN bam-1807 568 15 , , PUNCT bam-1807 568 16 jackson jackson PROPN bam-1807 568 17 mj mj PROPN bam-1807 568 18 . . PROPN bam-1807 568 19 contractile contractile NOUN bam-1807 568 20 activity activity NOUN bam-1807 568 21 - - PUNCT bam-1807 568 22 induced induce VERB bam-1807 568 23 oxidative oxidative ADJ bam-1807 568 24 stress stress NOUN bam-1807 568 25 : : PUNCT bam-1807 568 26 cellular cellular ADJ bam-1807 568 27 origin origin NOUN bam-1807 568 28 and and CCONJ bam-1807 568 29 adaptive adaptive ADJ bam-1807 568 30 responses response NOUN bam-1807 568 31 . . PUNCT bam-1807 569 1 am be AUX bam-1807 569 2 . . PUNCT bam-1807 570 1 j. j. PROPN bam-1807 570 2 physiol physiol PROPN bam-1807 570 3 . . PUNCT bam-1807 571 1 cell cell NOUN bam-1807 571 2 physiol physiol PROPN bam-1807 571 3 . . PUNCT bam-1807 572 1 2001 2001 NUM bam-1807 572 2 ; ; PUNCT bam-1807 572 3 280 280 NUM bam-1807 572 4 : : PUNCT bam-1807 572 5 c621 c621 PROPN bam-1807 572 6 - - SYM bam-1807 572 7 c627 c627 PROPN bam-1807 572 8 . . PUNCT bam-1807 573 1 [ [ X bam-1807 573 2 71 71 NUM bam-1807 573 3 ] ] X bam-1807 573 4 mcardle mcardle PROPN bam-1807 573 5 a a PROPN bam-1807 573 6 , , PUNCT bam-1807 573 7 van van PROPN bam-1807 573 8 der der NOUN bam-1807 573 9 meulen meulen VERB bam-1807 573 10 j j PROPN bam-1807 573 11 , , PUNCT bam-1807 573 12 close close ADJ bam-1807 573 13 gl gl NOUN bam-1807 573 14 , , PUNCT bam-1807 573 15 pattwell pattwell NOUN bam-1807 573 16 d d PROPN bam-1807 573 17 , , PUNCT bam-1807 573 18 van van PROPN bam-1807 573 19 remmen remman NOUN bam-1807 573 20 h h PROPN bam-1807 573 21 , , PUNCT bam-1807 573 22 huang huang PROPN bam-1807 573 23 tt tt PROPN bam-1807 573 24 , , PUNCT bam-1807 573 25 richardson richardson PROPN bam-1807 573 26 ag ag PROPN bam-1807 573 27 , , PUNCT bam-1807 573 28 epstein epstein PROPN bam-1807 573 29 cj cj PROPN bam-1807 573 30 , , PUNCT bam-1807 573 31 faulkner faulkner PROPN bam-1807 573 32 ja ja PROPN bam-1807 573 33 , , PUNCT bam-1807 573 34 jackson jackson PROPN bam-1807 573 35 mj mj PROPN bam-1807 573 36 . . PROPN bam-1807 573 37 role role NOUN bam-1807 573 38 of of ADP bam-1807 573 39 mitochondrial mitochondrial ADJ bam-1807 573 40 superoxide superoxide NOUN bam-1807 573 41 dismutase dismutase NOUN bam-1807 573 42 in in ADP bam-1807 573 43 contraction contraction NOUN bam-1807 573 44 - - PUNCT bam-1807 573 45 induced induce VERB bam-1807 573 46 generation generation NOUN bam-1807 573 47 of of ADP bam-1807 573 48 reactive reactive ADJ bam-1807 573 49 oxygen oxygen NOUN bam-1807 573 50 species specie NOUN bam-1807 573 51 in in ADP bam-1807 573 52 skeletal skeletal ADJ bam-1807 573 53 muscle muscle NOUN bam-1807 573 54 extracellular extracellular ADJ bam-1807 573 55 space space NOUN bam-1807 573 56 . . PUNCT bam-1807 574 1 am be AUX bam-1807 574 2 . . PUNCT bam-1807 575 1 j. j. PROPN bam-1807 575 2 physiol physiol PROPN bam-1807 575 3 . . PUNCT bam-1807 576 1 cell cell NOUN bam-1807 576 2 physiol physiol PROPN bam-1807 576 3 . . PUNCT bam-1807 577 1 2004 2004 NUM bam-1807 577 2 ; ; PUNCT bam-1807 578 1 286 286 NUM bam-1807 578 2 : : PUNCT bam-1807 578 3 c1152 c1152 PROPN bam-1807 578 4 - - PUNCT bam-1807 578 5 c1158 c1158 NOUN bam-1807 578 6 . . PUNCT bam-1807 579 1 [ [ X bam-1807 579 2 72 72 NUM bam-1807 579 3 ] ] X bam-1807 579 4 mcardle mcardle PROPN bam-1807 579 5 f f PROPN bam-1807 579 6 , , PUNCT bam-1807 579 7 spiers spiers PROPN bam-1807 579 8 s s PROPN bam-1807 579 9 , , PUNCT bam-1807 579 10 aldemir aldemir ADJ bam-1807 579 11 h h PROPN bam-1807 579 12 , , PUNCT bam-1807 579 13 vasilaki vasilaki PROPN bam-1807 579 14 a a DET bam-1807 579 15 , , PUNCT bam-1807 579 16 beaver beaver NOUN bam-1807 579 17 a a NOUN bam-1807 579 18 , , PUNCT bam-1807 579 19 iwanejko iwanejko PROPN bam-1807 579 20 l l PROPN bam-1807 579 21 , , PUNCT bam-1807 579 22 mcardle mcardle PROPN bam-1807 579 23 a a PROPN bam-1807 579 24 , , PUNCT bam-1807 579 25 jackson jackson PROPN bam-1807 579 26 mj mj PROPN bam-1807 579 27 . . PUNCT bam-1807 579 28 preconditioning precondition VERB bam-1807 579 29 of of ADP bam-1807 579 30 skeletal skeletal ADJ bam-1807 579 31 muscle muscle NOUN bam-1807 579 32 against against ADP bam-1807 579 33 contraction contraction NOUN bam-1807 579 34 - - PUNCT bam-1807 579 35 induced induce VERB bam-1807 579 36 damage damage NOUN bam-1807 579 37 : : PUNCT bam-1807 579 38 the the DET bam-1807 579 39 role role NOUN bam-1807 579 40 of of ADP bam-1807 579 41 adaptations adaptation NOUN bam-1807 579 42 to to ADP bam-1807 579 43 oxidants oxidant NOUN bam-1807 579 44 in in ADP bam-1807 579 45 mice mouse NOUN bam-1807 579 46 . . PUNCT bam-1807 580 1 j. j. PROPN bam-1807 580 2 physiol physiol PROPN bam-1807 580 3 . . PUNCT bam-1807 581 1 2004 2004 NUM bam-1807 581 2 ; ; PUNCT bam-1807 581 3 56:233 56:233 NUM bam-1807 581 4 - - SYM bam-1807 581 5 244 244 NUM bam-1807 581 6 . . PUNCT bam-1807 582 1 [ [ X bam-1807 582 2 73 73 NUM bam-1807 582 3 ] ] X bam-1807 582 4 mcclung mcclung PROPN bam-1807 582 5 jm jm PROPN bam-1807 582 6 , , PUNCT bam-1807 582 7 deruisseau deruisseau PROPN bam-1807 582 8 kc kc PROPN bam-1807 582 9 , , PUNCT bam-1807 582 10 whidden whidden ADJ bam-1807 582 11 ma ma PROPN bam-1807 582 12 , , PUNCT bam-1807 582 13 van van PROPN bam-1807 582 14 remmen remman NOUN bam-1807 582 15 h h PROPN bam-1807 582 16 , , PUNCT bam-1807 582 17 richardson richardson PROPN bam-1807 582 18 a a PRON bam-1807 582 19 , , PUNCT bam-1807 582 20 song song NOUN bam-1807 582 21 w w PROPN bam-1807 582 22 , , PUNCT bam-1807 582 23 vrabas vrabas PROPN bam-1807 582 24 is be AUX bam-1807 582 25 , , PUNCT bam-1807 582 26 powers power NOUN bam-1807 582 27 sk sk VERB bam-1807 582 28 . . PROPN bam-1807 582 29 overexpression overexpression NOUN bam-1807 582 30 of of ADP bam-1807 582 31 antioxidant antioxidant ADJ bam-1807 582 32 enzymes enzyme NOUN bam-1807 582 33 in in ADP bam-1807 582 34 diaphragm diaphragm NOUN bam-1807 582 35 muscle muscle NOUN bam-1807 582 36 does do AUX bam-1807 582 37 not not PART bam-1807 582 38 alter alter VERB bam-1807 582 39 contraction contraction NOUN bam-1807 582 40 - - PUNCT bam-1807 582 41 induced induce VERB bam-1807 582 42 fatigue fatigue NOUN bam-1807 582 43 or or CCONJ bam-1807 582 44 recovery recovery NOUN bam-1807 582 45 . . PUNCT bam-1807 583 1 exp exp PROPN bam-1807 583 2 . . PUNCT bam-1807 583 3 physiol physiol PROPN bam-1807 583 4 . . PUNCT bam-1807 584 1 2010 2010 NUM bam-1807 584 2 ; ; PUNCT bam-1807 584 3 95:222 95:222 NUM bam-1807 584 4 - - SYM bam-1807 584 5 231 231 NUM bam-1807 584 6 . . PUNCT bam-1807 585 1 [ [ X bam-1807 585 2 74 74 NUM bam-1807 585 3 ] ] X bam-1807 585 4 miyazaki miyazaki PROPN bam-1807 585 5 m m PROPN bam-1807 585 6 , , PUNCT bam-1807 585 7 esser esser PROPN bam-1807 585 8 ka ka PROPN bam-1807 585 9 . . PROPN bam-1807 585 10 cellular cellular ADJ bam-1807 585 11 mechanisms mechanism NOUN bam-1807 585 12 regulating regulate VERB bam-1807 585 13 protein protein NOUN bam-1807 585 14 synthesis synthesis NOUN bam-1807 585 15 and and CCONJ bam-1807 585 16 skeletal skeletal ADJ bam-1807 585 17 muscle muscle NOUN bam-1807 585 18 hypertrophy hypertrophy NOUN bam-1807 585 19 in in ADP bam-1807 585 20 animals animal NOUN bam-1807 585 21 . . PUNCT bam-1807 586 1 j j PROPN bam-1807 586 2 appl appl PROPN bam-1807 586 3 physiol physiol PROPN bam-1807 586 4 . . PUNCT bam-1807 587 1 2009;106:1367 2009;106:1367 NUM bam-1807 587 2 - - SYM bam-1807 587 3 1373 1373 NUM bam-1807 587 4 . . PUNCT bam-1807 588 1 [ [ X bam-1807 588 2 75 75 NUM bam-1807 588 3 ] ] X bam-1807 588 4 moylan moylan PROPN bam-1807 588 5 , , PUNCT bam-1807 588 6 j.s j.s PROPN bam-1807 588 7 . . PROPN bam-1807 588 8 and and CCONJ bam-1807 588 9 reid reid PROPN bam-1807 588 10 , , PUNCT bam-1807 588 11 m.b m.b PROPN bam-1807 588 12 . . PROPN bam-1807 588 13 oxidative oxidative ADJ bam-1807 588 14 stress stress NOUN bam-1807 588 15 , , PUNCT bam-1807 588 16 chronic chronic ADJ bam-1807 588 17 disease disease NOUN bam-1807 588 18 , , PUNCT bam-1807 588 19 and and CCONJ bam-1807 588 20 muscle muscle NOUN bam-1807 588 21 wasting waste VERB bam-1807 588 22 . . PUNCT bam-1807 589 1 muscle muscle NOUN bam-1807 589 2 nerve nerve NOUN bam-1807 589 3 2007 2007 NUM bam-1807 589 4 ; ; PUNCT bam-1807 589 5 35:411–429 35:411–429 NUM bam-1807 589 6 . . PUNCT bam-1807 590 1 [ [ X bam-1807 590 2 76 76 NUM bam-1807 590 3 ] ] X bam-1807 590 4 morton morton PROPN bam-1807 590 5 jp jp PROPN bam-1807 590 6 , , PUNCT bam-1807 590 7 kayani kayani PROPN bam-1807 590 8 ac ac PROPN bam-1807 590 9 , , PUNCT bam-1807 590 10 mcardle mcardle PROPN bam-1807 590 11 a a PRON bam-1807 590 12 , , PUNCT bam-1807 590 13 drust drust AUX bam-1807 590 14 b. b. PROPN bam-1807 590 15 the the DET bam-1807 590 16 exercise exercise NOUN bam-1807 590 17 - - PUNCT bam-1807 590 18 induced induce VERB bam-1807 590 19 stress stress NOUN bam-1807 590 20 response response NOUN bam-1807 590 21 of of ADP bam-1807 590 22 skeletal skeletal ADJ bam-1807 590 23 muscle muscle NOUN bam-1807 590 24 , , PUNCT bam-1807 590 25 with with ADP bam-1807 590 26 specific specific ADJ bam-1807 590 27 emphasis emphasis NOUN bam-1807 590 28 on on ADP bam-1807 590 29 humans human NOUN bam-1807 590 30 . . PUNCT bam-1807 591 1 sports sport NOUN bam-1807 591 2 med med PROPN bam-1807 591 3 . . PUNCT bam-1807 591 4 2009 2009 NUM bam-1807 591 5 ; ; PUNCT bam-1807 591 6 39:643 39:643 NUM bam-1807 591 7 - - SYM bam-1807 591 8 662 662 NUM bam-1807 591 9 . . PUNCT bam-1807 592 1 [ [ X bam-1807 592 2 77 77 NUM bam-1807 592 3 ] ] X bam-1807 592 4 nader nader PROPN bam-1807 592 5 ga ga PROPN bam-1807 592 6 . . PROPN bam-1807 592 7 concurrent concurrent ADJ bam-1807 592 8 strength strength NOUN bam-1807 592 9 and and CCONJ bam-1807 592 10 endurance endurance NOUN bam-1807 592 11 training training NOUN bam-1807 592 12 : : PUNCT bam-1807 592 13 from from ADP bam-1807 592 14 molecules molecule NOUN bam-1807 592 15 to to ADP bam-1807 592 16 man man NOUN bam-1807 592 17 . . PUNCT bam-1807 593 1 med med PROPN bam-1807 593 2 . . PUNCT bam-1807 594 1 sci sci PROPN bam-1807 594 2 . . PUNCT bam-1807 594 3 sports sport NOUN bam-1807 594 4 exerc exerc PROPN bam-1807 594 5 . . PUNCT bam-1807 595 1 2006 2006 NUM bam-1807 595 2 ; ; PUNCT bam-1807 595 3 38:1965 38:1965 NOUN bam-1807 595 4 - - SYM bam-1807 595 5 1970 1970 NUM bam-1807 595 6 . . PUNCT bam-1807 596 1 [ [ X bam-1807 596 2 78 78 NUM bam-1807 596 3 ] ] PUNCT bam-1807 596 4 o’connor o’connor ADV bam-1807 596 5 rs rs NOUN bam-1807 596 6 , , PUNCT bam-1807 596 7 pavlath pavlath PROPN bam-1807 596 8 gk gk PROPN bam-1807 596 9 , , PUNCT bam-1807 596 10 mccarthy mccarthy PROPN bam-1807 596 11 jj jj PROPN bam-1807 596 12 , , PUNCT bam-1807 596 13 esser esser PROPN bam-1807 596 14 ka ka PROPN bam-1807 596 15 . . PROPN bam-1807 596 16 point point NOUN bam-1807 596 17 : : PUNCT bam-1807 596 18 counterpoint counterpoint NOUN bam-1807 596 19 : : PUNCT bam-1807 596 20 satellite satellite NOUN bam-1807 596 21 cell cell NOUN bam-1807 596 22 addition addition NOUN bam-1807 596 23 is be AUX bam-1807 596 24 / / PUNCT bam-1807 596 25 is be AUX bam-1807 596 26 not not PART bam-1807 596 27 obligatory obligatory ADJ bam-1807 596 28 for for ADP bam-1807 596 29 skeletal skeletal ADJ bam-1807 596 30 muscle muscle NOUN bam-1807 596 31 hypertrophy hypertrophy NOUN bam-1807 596 32 . . PUNCT bam-1807 597 1 j. j. PROPN bam-1807 597 2 appl appl PROPN bam-1807 597 3 . . PUNCT bam-1807 597 4 physiol physiol PROPN bam-1807 597 5 : : PUNCT bam-1807 597 6 2007 2007 NUM bam-1807 597 7 ; ; PUNCT bam-1807 597 8 103 103 NUM bam-1807 597 9 : : SYM bam-1807 597 10 1107 1107 NUM bam-1807 597 11 . . PUNCT bam-1807 598 1 [ [ X bam-1807 598 2 79 79 NUM bam-1807 598 3 ] ] X bam-1807 598 4 ohsawa ohsawa PROPN bam-1807 598 5 y y PROPN bam-1807 598 6 , , PUNCT bam-1807 598 7 okada okada PROPN bam-1807 598 8 t t PROPN bam-1807 598 9 , , PUNCT bam-1807 598 10 kuga kuga PROPN bam-1807 598 11 a a X bam-1807 598 12 , , PUNCT bam-1807 598 13 hayashi hayashi PROPN bam-1807 598 14 s s PROPN bam-1807 598 15 , , PUNCT bam-1807 598 16 murakami murakami PROPN bam-1807 598 17 t t PROPN bam-1807 598 18 , , PUNCT bam-1807 598 19 tsuchida tsuchida PROPN bam-1807 598 20 k k PROPN bam-1807 598 21 , , PUNCT bam-1807 598 22 noji noji PROPN bam-1807 598 23 s s PROPN bam-1807 598 24 , , PUNCT bam-1807 598 25 sunada sunada PROPN bam-1807 598 26 y. y. PROPN bam-1807 598 27 caveolin-3 caveolin-3 PROPN bam-1807 598 28 regulates regulate VERB bam-1807 598 29 myostatin myostatin ADJ bam-1807 598 30 signaling signal VERB bam-1807 598 31 . . PUNCT bam-1807 598 32 minireview minireview PROPN bam-1807 598 33 . . PUNCT bam-1807 599 1 acta acta PROPN bam-1807 599 2 myol myol PROPN bam-1807 599 3 . . PUNCT bam-1807 600 1 2008;27:19 2008;27:19 NUM bam-1807 600 2 - - SYM bam-1807 600 3 24 24 NUM bam-1807 600 4 . . PUNCT bam-1807 601 1 [ [ X bam-1807 601 2 80 80 NUM bam-1807 601 3 ] ] X bam-1807 601 4 phaneuf phaneuf NOUN bam-1807 601 5 s s PROPN bam-1807 601 6 , , PUNCT bam-1807 601 7 leeuwenburgh leeuwenburgh PROPN bam-1807 601 8 c. c. PROPN bam-1807 601 9 apoptosis apoptosis NOUN bam-1807 601 10 and and CCONJ bam-1807 601 11 exercise exercise NOUN bam-1807 601 12 . . PUNCT bam-1807 602 1 med med PROPN bam-1807 602 2 . . PUNCT bam-1807 603 1 sci sci PROPN bam-1807 603 2 . . PUNCT bam-1807 603 3 sports sport NOUN bam-1807 603 4 exerc exerc PROPN bam-1807 603 5 . . PUNCT bam-1807 603 6 2001 2001 NUM bam-1807 603 7 ; ; PUNCT bam-1807 603 8 33:393396 33:393396 X bam-1807 603 9 . . PUNCT bam-1807 604 1 [ [ X bam-1807 604 2 81 81 NUM bam-1807 604 3 ] ] PUNCT bam-1807 604 4 pedersen pedersen PROPN bam-1807 604 5 bk bk PROPN bam-1807 604 6 , , PUNCT bam-1807 604 7 febbraio febbraio PROPN bam-1807 604 8 ma ma PROPN bam-1807 604 9 . . PROPN bam-1807 604 10 muscle muscle NOUN bam-1807 604 11 as as ADP bam-1807 604 12 an an DET bam-1807 604 13 endocrine endocrine NOUN bam-1807 604 14 organ organ NOUN bam-1807 604 15 : : PUNCT bam-1807 604 16 focus focus VERB bam-1807 604 17 on on ADP bam-1807 604 18 muscle muscle NOUN bam-1807 604 19 - - PUNCT bam-1807 604 20 derived derive VERB bam-1807 604 21 interleukin-6 interleukin-6 NOUN bam-1807 604 22 . . PUNCT bam-1807 605 1 physiol physiol PROPN bam-1807 605 2 rev rev PROPN bam-1807 605 3 . . PROPN bam-1807 605 4 2008 2008 NUM bam-1807 605 5 ; ; PUNCT bam-1807 605 6 88:1379 88:1379 NOUN bam-1807 605 7 - - SYM bam-1807 605 8 1406 1406 NUM bam-1807 605 9 . . PUNCT bam-1807 606 1 [ [ X bam-1807 606 2 82 82 NUM bam-1807 606 3 ] ] X bam-1807 606 4 petrella petrella NOUN bam-1807 606 5 jk jk PROPN bam-1807 606 6 , , PUNCT bam-1807 606 7 kim kim PROPN bam-1807 606 8 js js PROPN bam-1807 606 9 , , PUNCT bam-1807 606 10 mayhew mayhew PROPN bam-1807 606 11 dl dl PROPN bam-1807 606 12 , , PUNCT bam-1807 606 13 cross cross PROPN bam-1807 606 14 jm jm PROPN bam-1807 606 15 , , PUNCT bam-1807 606 16 bamman bamman NOUN bam-1807 606 17 mm mm PROPN bam-1807 606 18 . . PUNCT bam-1807 606 19 potent potent ADJ bam-1807 606 20 myofiber myofiber ADJ bam-1807 606 21 hypertrophy hypertrophy NOUN bam-1807 606 22 during during ADP bam-1807 606 23 resistance resistance NOUN bam-1807 606 24 training training NOUN bam-1807 606 25 in in ADP bam-1807 606 26 humans human NOUN bam-1807 606 27 is be AUX bam-1807 606 28 associated associate VERB bam-1807 606 29 with with ADP bam-1807 606 30 satellite satellite NOUN bam-1807 606 31 cell cell NOUN bam-1807 606 32 - - PUNCT bam-1807 606 33 mediated mediate VERB bam-1807 606 34 myonuclear myonuclear NOUN bam-1807 606 35 addition addition NOUN bam-1807 606 36 : : PUNCT bam-1807 606 37 a a DET bam-1807 606 38 cluster cluster NOUN bam-1807 606 39 analysis analysis NOUN bam-1807 606 40 . . PUNCT bam-1807 607 1 j. j. PROPN bam-1807 607 2 appl appl PROPN bam-1807 607 3 . . PUNCT bam-1807 607 4 physiol physiol PROPN bam-1807 607 5 . . PUNCT bam-1807 608 1 2008 2008 NUM bam-1807 608 2 ; ; PUNCT bam-1807 609 1 104:1736 104:1736 NUM bam-1807 609 2 - - SYM bam-1807 609 3 1742 1742 NUM bam-1807 609 4 . . PUNCT bam-1807 610 1 [ [ X bam-1807 610 2 83 83 NUM bam-1807 610 3 ] ] X bam-1807 610 4 pette pette NOUN bam-1807 610 5 d d PROPN bam-1807 610 6 , , PUNCT bam-1807 610 7 staron staron NOUN bam-1807 610 8 rs rs NOUN bam-1807 610 9 , , PUNCT bam-1807 610 10 transitions transition NOUN bam-1807 610 11 of of ADP bam-1807 610 12 muscle muscle NOUN bam-1807 610 13 fiber fiber NOUN bam-1807 610 14 phenotypic phenotypic ADJ bam-1807 610 15 profiles profile NOUN bam-1807 610 16 . . PUNCT bam-1807 611 1 histochem histochem PROPN bam-1807 611 2 . . PUNCT bam-1807 612 1 cell cell NOUN bam-1807 612 2 . . PUNCT bam-1807 613 1 biol biol PROPN bam-1807 613 2 . . PUNCT bam-1807 614 1 2001;115:359 2001;115:359 NUM bam-1807 614 2 - - SYM bam-1807 614 3 372 372 NUM bam-1807 614 4 . . PUNCT bam-1807 615 1 [ [ X bam-1807 615 2 84 84 NUM bam-1807 615 3 ] ] X bam-1807 615 4 powers power NOUN bam-1807 615 5 sk sk VERB bam-1807 615 6 , , PUNCT bam-1807 615 7 ji ji PROPN bam-1807 615 8 ll ll PROPN bam-1807 615 9 , , PUNCT bam-1807 615 10 leeuwenburgh leeuwenburgh PROPN bam-1807 615 11 c. c. PROPN bam-1807 615 12 exercise exercise NOUN bam-1807 615 13 training training NOUN bam-1807 615 14 - - PUNCT bam-1807 615 15 induced induce VERB bam-1807 615 16 alterations alteration NOUN bam-1807 615 17 in in ADP bam-1807 615 18 skeletal skeletal ADJ bam-1807 615 19 muscle muscle NOUN bam-1807 615 20 antioxidant antioxidant ADJ bam-1807 615 21 capacity capacity NOUN bam-1807 615 22 : : PUNCT bam-1807 615 23 a a DET bam-1807 615 24 brief brief ADJ bam-1807 615 25 review review NOUN bam-1807 615 26 . . PUNCT bam-1807 616 1 med med PROPN bam-1807 616 2 . . PUNCT bam-1807 617 1 sci sci PROPN bam-1807 617 2 . . PUNCT bam-1807 617 3 sports sport NOUN bam-1807 617 4 exerc exerc PROPN bam-1807 617 5 . . PUNCT bam-1807 617 6 1999 1999 NUM bam-1807 617 7 ; ; PUNCT bam-1807 617 8 31:987 31:987 NUM bam-1807 617 9 - - SYM bam-1807 617 10 997 997 NUM bam-1807 617 11 . . PUNCT bam-1807 618 1 [ [ X bam-1807 618 2 85 85 NUM bam-1807 618 3 ] ] X bam-1807 618 4 powers power NOUN bam-1807 618 5 sk sk VERB bam-1807 618 6 , , PUNCT bam-1807 618 7 jackson jackson PROPN bam-1807 618 8 mj mj PROPN bam-1807 618 9 . . PROPN bam-1807 618 10 exercise exercise NOUN bam-1807 618 11 - - PUNCT bam-1807 618 12 induced induce VERB bam-1807 618 13 oxidative oxidative ADJ bam-1807 618 14 stress stress NOUN bam-1807 618 15 : : PUNCT bam-1807 618 16 cellular cellular ADJ bam-1807 618 17 mechanisms mechanism NOUN bam-1807 618 18 and and CCONJ bam-1807 618 19 impact impact NOUN bam-1807 618 20 on on ADP bam-1807 618 21 muscle muscle NOUN bam-1807 618 22 force force NOUN bam-1807 618 23 production production NOUN bam-1807 618 24 . . PUNCT bam-1807 619 1 physiol physiol PROPN bam-1807 619 2 . . PUNCT bam-1807 620 1 rev rev PROPN bam-1807 620 2 . . PROPN bam-1807 620 3 2008 2008 NUM bam-1807 620 4 ; ; PUNCT bam-1807 620 5 88:1243–1276 88:1243–1276 NUM bam-1807 620 6 . . PUNCT bam-1807 621 1 [ [ X bam-1807 621 2 86 86 NUM bam-1807 621 3 ] ] PUNCT bam-1807 621 4 puntschart puntschart NOUN bam-1807 621 5 a a PRON bam-1807 621 6 , , PUNCT bam-1807 621 7 claassen claassen NOUN bam-1807 621 8 h h NOUN bam-1807 621 9 , , PUNCT bam-1807 621 10 jostarndt jostarndt PROPN bam-1807 621 11 k k PROPN bam-1807 621 12 , , PUNCT bam-1807 621 13 hoppeler hoppeler ADJ bam-1807 621 14 h h NOUN bam-1807 621 15 , , PUNCT bam-1807 621 16 billeter billeter PROPN bam-1807 621 17 r. r. PROPN bam-1807 621 18 mrnas mrnas PROPN bam-1807 621 19 of of ADP bam-1807 621 20 enzymes enzyme NOUN bam-1807 621 21 involved involve VERB bam-1807 621 22 in in ADP bam-1807 621 23 energy energy NOUN bam-1807 621 24 metabolism metabolism NOUN bam-1807 621 25 and and CCONJ bam-1807 621 26 mtdna mtdna NOUN bam-1807 621 27 are be AUX bam-1807 621 28 increased increase VERB bam-1807 621 29 in in ADP bam-1807 621 30 endurance endurance NOUN bam-1807 621 31 - - PUNCT bam-1807 621 32 trained train VERB bam-1807 621 33 athletes athlete NOUN bam-1807 621 34 . . PUNCT bam-1807 622 1 am be AUX bam-1807 622 2 . . PUNCT bam-1807 623 1 j. j. PROPN bam-1807 623 2 physiol physiol PROPN bam-1807 623 3 . . PUNCT bam-1807 624 1 1995 1995 NUM bam-1807 624 2 ; ; PUNCT bam-1807 624 3 269 269 NUM bam-1807 624 4 : : PUNCT bam-1807 624 5 c619 c619 NUM bam-1807 624 6 – – PUNCT bam-1807 624 7 c625 c625 NUM bam-1807 624 8 . . PUNCT bam-1807 625 1 [ [ X bam-1807 625 2 87 87 NUM bam-1807 625 3 ] ] PUNCT bam-1807 625 4 radák radák PROPN bam-1807 625 5 z z PROPN bam-1807 625 6 , , PUNCT bam-1807 625 7 naito naito PROPN bam-1807 625 8 h h PROPN bam-1807 625 9 , , PUNCT bam-1807 625 10 kaneko kaneko PROPN bam-1807 625 11 t t PROPN bam-1807 625 12 , , PUNCT bam-1807 625 13 nakamoto nakamoto NOUN bam-1807 625 14 h h NOUN bam-1807 625 15 , , PUNCT bam-1807 625 16 takahashi takahashi PROPN bam-1807 625 17 r r PROPN bam-1807 625 18 , , PUNCT bam-1807 625 19 cardozo cardozo PROPN bam-1807 625 20 - - PUNCT bam-1807 625 21 pelaez pelaez PROPN bam-1807 625 22 f. f. PROPN bam-1807 625 23 , , PUNCT bam-1807 625 24 goto goto ADJ bam-1807 625 25 s. s. PROPN bam-1807 625 26 exercise exercise PROPN bam-1807 625 27 training training NOUN bam-1807 625 28 decreases decrease VERB bam-1807 625 29 dna dna NOUN bam-1807 625 30 damage damage NOUN bam-1807 625 31 and and CCONJ bam-1807 625 32 increases increase VERB bam-1807 625 33 dna dna PROPN bam-1807 625 34 repair repair NOUN bam-1807 625 35 and and CCONJ bam-1807 625 36 resistance resistance NOUN bam-1807 625 37 against against ADP bam-1807 625 38 oxidative oxidative ADJ bam-1807 625 39 stress stress NOUN bam-1807 625 40 of of ADP bam-1807 625 41 proteins protein NOUN bam-1807 625 42 in in ADP bam-1807 625 43 aged aged ADJ bam-1807 625 44 skeletal skeletal ADJ bam-1807 625 45 muscle muscle NOUN bam-1807 625 46 . . PUNCT bam-1807 626 1 pflugers pfluger NOUN bam-1807 626 2 arch arch VERB bam-1807 626 3 . . PUNCT bam-1807 627 1 2002 2002 NUM bam-1807 627 2 ; ; PUNCT bam-1807 627 3 445:273 445:273 NUM bam-1807 627 4 - - PUNCT bam-1807 627 5 278 278 NUM bam-1807 627 6 . . PUNCT bam-1807 628 1 [ [ X bam-1807 628 2 88 88 NUM bam-1807 628 3 ] ] X bam-1807 628 4 reid reid PROPN bam-1807 628 5 , , PUNCT bam-1807 628 6 m.b m.b PROPN bam-1807 628 7 . . PROPN bam-1807 628 8 free free ADJ bam-1807 628 9 radicals radical NOUN bam-1807 628 10 and and CCONJ bam-1807 628 11 muscle muscle NOUN bam-1807 628 12 fatigue fatigue NOUN bam-1807 628 13 : : PUNCT bam-1807 628 14 of of ADP bam-1807 628 15 ros ros PROPN bam-1807 628 16 , , PUNCT bam-1807 628 17 canaries canary NOUN bam-1807 628 18 , , PUNCT bam-1807 628 19 and and CCONJ bam-1807 628 20 the the DET bam-1807 628 21 ioc ioc PROPN bam-1807 628 22 . . PUNCT bam-1807 629 1 free free ADJ bam-1807 629 2 radic radic NOUN bam-1807 629 3 . . PUNCT bam-1807 630 1 biol biol PROPN bam-1807 630 2 . . PUNCT bam-1807 631 1 med med PROPN bam-1807 631 2 . . PROPN bam-1807 631 3 2008 2008 NUM bam-1807 631 4 ; ; PUNCT bam-1807 631 5 44:169–179 44:169–179 PROPN bam-1807 631 6 . . PUNCT bam-1807 632 1 [ [ X bam-1807 632 2 89 89 NUM bam-1807 632 3 ] ] PUNCT bam-1807 632 4 rivilis rivili NOUN bam-1807 632 5 i i PRON bam-1807 632 6 , , PUNCT bam-1807 632 7 milkiewicz milkiewicz PROPN bam-1807 632 8 m m PROPN bam-1807 632 9 , , PUNCT bam-1807 632 10 boyd boyd PROPN bam-1807 632 11 p p PROPN bam-1807 632 12 , , PUNCT bam-1807 632 13 goldstein goldstein PROPN bam-1807 632 14 j j PROPN bam-1807 632 15 , , PUNCT bam-1807 632 16 brown brown PROPN bam-1807 632 17 md md PROPN bam-1807 632 18 , , PUNCT bam-1807 632 19 egginton egginton PROPN bam-1807 632 20 s s PROPN bam-1807 632 21 , , PUNCT bam-1807 632 22 hansen hansen PROPN bam-1807 632 23 fm fm PROPN bam-1807 632 24 , , PUNCT bam-1807 632 25 hudlická hudlická NOUN bam-1807 632 26 o o PROPN bam-1807 632 27 , , PUNCT bam-1807 632 28 haas haas PROPN bam-1807 632 29 tl tl PROPN bam-1807 632 30 . . PROPN bam-1807 632 31 differential differential PROPN bam-1807 632 32 involvement involvement NOUN bam-1807 632 33 of of ADP bam-1807 632 34 mmp2 mmp2 PROPN bam-1807 632 35 and and CCONJ bam-1807 632 36 vegf vegf PROPN bam-1807 632 37 during during ADP bam-1807 632 38 muscle muscle NOUN bam-1807 632 39 stretchversus stretchversus PROPN bam-1807 632 40 shear shear NOUN bam-1807 632 41 stress stress NOUN bam-1807 632 42 - - PUNCT bam-1807 632 43 induced induce VERB bam-1807 632 44 angiogenesis angiogenesis NOUN bam-1807 632 45 . . PUNCT bam-1807 633 1 am be AUX bam-1807 633 2 . . PUNCT bam-1807 634 1 j. j. PROPN bam-1807 634 2 physiol physiol PROPN bam-1807 634 3 . . PUNCT bam-1807 635 1 heart heart NOUN bam-1807 635 2 circ circ PROPN bam-1807 635 3 . . PUNCT bam-1807 636 1 physiol physiol PROPN bam-1807 636 2 . . PUNCT bam-1807 637 1 2002 2002 NUM bam-1807 637 2 ; ; PUNCT bam-1807 637 3 283 283 NUM bam-1807 637 4 : : PUNCT bam-1807 637 5 h1430 h1430 PROPN bam-1807 637 6 - - PUNCT bam-1807 637 7 h1438 h1438 NOUN bam-1807 637 8 . . PUNCT bam-1807 638 1 [ [ X bam-1807 638 2 90 90 NUM bam-1807 638 3 ] ] PUNCT bam-1807 638 4 ristow ristow PROPN bam-1807 638 5 m m PROPN bam-1807 638 6 , , PUNCT bam-1807 638 7 zarse zarse PROPN bam-1807 638 8 k k NOUN bam-1807 638 9 , , PUNCT bam-1807 638 10 oberbach oberbach NOUN bam-1807 638 11 a a PRON bam-1807 638 12 , , PUNCT bam-1807 638 13 klöting klöting NOUN bam-1807 638 14 n n CCONJ bam-1807 638 15 , , PUNCT bam-1807 638 16 birringer birringer PROPN bam-1807 638 17 m m PROPN bam-1807 638 18 , , PUNCT bam-1807 638 19 kiehntopf kiehntopf PROPN bam-1807 638 20 m m PROPN bam-1807 638 21 , , PUNCT bam-1807 638 22 stumvoll stumvoll PROPN bam-1807 638 23 m m PROPN bam-1807 638 24 , , PUNCT bam-1807 638 25 kahn kahn PROPN bam-1807 638 26 cr cr PROPN bam-1807 638 27 , , PUNCT bam-1807 638 28 blüher blüher ADJ bam-1807 638 29 m. m. NOUN bam-1807 638 30 antioxidants antioxidant NOUN bam-1807 638 31 prevent prevent VERB bam-1807 638 32 healthpromoting healthpromote VERB bam-1807 638 33 effects effect NOUN bam-1807 638 34 of of ADP bam-1807 638 35 physical physical ADJ bam-1807 638 36 exercise exercise NOUN bam-1807 638 37 in in ADP bam-1807 638 38 humans human NOUN bam-1807 638 39 . . PUNCT bam-1807 639 1 proc proc NOUN bam-1807 639 2 . . PUNCT bam-1807 640 1 natl natl PROPN bam-1807 640 2 . . PUNCT bam-1807 641 1 acad acad PROPN bam-1807 641 2 . . PUNCT bam-1807 642 1 sci sci PROPN bam-1807 642 2 . . PUNCT bam-1807 643 1 u u PROPN bam-1807 643 2 s s PROPN bam-1807 643 3 a. a. NOUN bam-1807 643 4 2009 2009 NUM bam-1807 643 5 ; ; PUNCT bam-1807 643 6 106:8665 106:8665 NUM bam-1807 643 7 - - SYM bam-1807 643 8 8670 8670 NUM bam-1807 643 9 . . PUNCT bam-1807 644 1 [ [ X bam-1807 644 2 91 91 NUM bam-1807 644 3 ] ] X bam-1807 644 4 röckl röckl NOUN bam-1807 644 5 ksc ksc PROPN bam-1807 644 6 , , PUNCT bam-1807 644 7 witczak witczak NOUN bam-1807 644 8 ca can AUX bam-1807 644 9 , , PUNCT bam-1807 644 10 goodyear goodyear PROPN bam-1807 644 11 lj lj PROPN bam-1807 644 12 . . PUNCT bam-1807 645 1 signaling signal VERB bam-1807 645 2 mechanisms mechanism NOUN bam-1807 645 3 in in ADP bam-1807 645 4 skeletal skeletal ADJ bam-1807 645 5 muscle muscle NOUN bam-1807 645 6 : : PUNCT bam-1807 645 7 acute acute ADJ bam-1807 645 8 responses response NOUN bam-1807 645 9 and and CCONJ bam-1807 645 10 chronic chronic ADJ bam-1807 645 11 adaptatiuons adaptatiuon NOUN bam-1807 645 12 to to PART bam-1807 645 13 exercise exercise VERB bam-1807 645 14 . . PUNCT bam-1807 646 1 life life NOUN bam-1807 646 2 2008 2008 NUM bam-1807 646 3 ; ; PUNCT bam-1807 646 4 60:145 60:145 PROPN bam-1807 646 5 - - SYM bam-1807 646 6 153 153 NUM bam-1807 646 7 . . PUNCT bam-1807 647 1 [ [ X bam-1807 647 2 92 92 NUM bam-1807 647 3 ] ] PUNCT bam-1807 647 4 rosa rosa PROPN bam-1807 647 5 neto neto PROPN bam-1807 647 6 jc jc PROPN bam-1807 647 7 , , PUNCT bam-1807 647 8 lira lira PROPN bam-1807 647 9 fs fs PROPN bam-1807 647 10 , , PUNCT bam-1807 647 11 oyama oyama PROPN bam-1807 647 12 lm lm PROPN bam-1807 647 13 , , PUNCT bam-1807 647 14 zanchi zanchi PROPN bam-1807 647 15 ne ne PROPN bam-1807 647 16 , , PUNCT bam-1807 647 17 yamashita yamashita PROPN bam-1807 647 18 as as ADP bam-1807 647 19 , , PUNCT bam-1807 647 20 batista batista PROPN bam-1807 647 21 ml ml PROPN bam-1807 647 22 jr jr PROPN bam-1807 647 23 , , PUNCT bam-1807 647 24 oller oller PROPN bam-1807 647 25 do do AUX bam-1807 647 26 nascimento nascimento PROPN bam-1807 647 27 cm cm PROPN bam-1807 647 28 , , PUNCT bam-1807 647 29 seelaender seelaender NOUN bam-1807 647 30 m. m. PROPN bam-1807 647 31 exhaustive exhaustive ADJ bam-1807 647 32 exercise exercise NOUN bam-1807 647 33 causes cause VERB bam-1807 647 34 an an DET bam-1807 647 35 anti anti ADJ bam-1807 647 36 - - ADJ bam-1807 647 37 inflammatory inflammatory ADJ bam-1807 647 38 effect effect NOUN bam-1807 647 39 in in ADP bam-1807 647 40 skeletal skeletal ADJ bam-1807 647 41 muscle muscle NOUN bam-1807 647 42 and and CCONJ bam-1807 647 43 a a DET bam-1807 647 44 pro pro ADJ bam-1807 647 45 - - ADJ bam-1807 647 46 inflammatory inflammatory ADJ bam-1807 647 47 effect effect NOUN bam-1807 647 48 the the DET bam-1807 647 49 exercised exercise VERB bam-1807 647 50 skeletal skeletal ADJ bam-1807 647 51 muscle muscle NOUN bam-1807 647 52 european european PROPN bam-1807 647 53 journal journal PROPN bam-1807 647 54 translational translational ADJ bam-1807 647 55 myology myology NOUN bam-1807 647 56 myology myology NOUN bam-1807 647 57 reviews review VERB bam-1807 647 58 20 20 NUM bam-1807 647 59 ( ( PUNCT bam-1807 647 60 3 3 NUM bam-1807 647 61 ): ): PUNCT bam-1807 647 62 105 105 NUM bam-1807 647 63 - - SYM bam-1807 647 64 120 120 NUM bam-1807 647 65 , , PUNCT bam-1807 647 66 2010 2010 NUM bam-1807 647 67 119 119 NUM bam-1807 647 68 in in ADP bam-1807 647 69 adipose adipose PRON bam-1807 647 70 tissue tissue NOUN bam-1807 647 71 in in ADP bam-1807 647 72 rats rat NOUN bam-1807 647 73 . . PUNCT bam-1807 648 1 eur eur PROPN bam-1807 648 2 . . PUNCT bam-1807 649 1 j. j. PROPN bam-1807 649 2 appl appl PROPN bam-1807 649 3 . . PUNCT bam-1807 649 4 physiol physiol PROPN bam-1807 649 5 . . PUNCT bam-1807 650 1 2009 2009 NUM bam-1807 650 2 ; ; PUNCT bam-1807 650 3 106:697 106:697 X bam-1807 650 4 - - PUNCT bam-1807 650 5 704 704 NUM bam-1807 650 6 . . PUNCT bam-1807 651 1 [ [ X bam-1807 651 2 93 93 NUM bam-1807 651 3 ] ] PUNCT bam-1807 651 4 sahlin sahlin PROPN bam-1807 651 5 k k PROPN bam-1807 651 6 , , PUNCT bam-1807 651 7 shabalina shabalina PROPN bam-1807 651 8 ig ig PROPN bam-1807 651 9 , , PUNCT bam-1807 651 10 mattsson mattsson NOUN bam-1807 651 11 cm cm PROPN bam-1807 651 12 , , PUNCT bam-1807 651 13 bakkman bakkman ADJ bam-1807 651 14 l l NOUN bam-1807 651 15 , , PUNCT bam-1807 651 16 fernström fernström NOUN bam-1807 651 17 m m NOUN bam-1807 651 18 , , PUNCT bam-1807 651 19 rozhdestvenskaya rozhdestvenskaya PROPN bam-1807 651 20 z z NOUN bam-1807 651 21 , , PUNCT bam-1807 651 22 enqvist enqvist PROPN bam-1807 651 23 jk jk PROPN bam-1807 651 24 , , PUNCT bam-1807 651 25 nedergaard nedergaard PROPN bam-1807 651 26 j j PROPN bam-1807 651 27 , , PUNCT bam-1807 651 28 ekblom ekblom NOUN bam-1807 651 29 bt bt NOUN bam-1807 651 30 , , PUNCT bam-1807 651 31 tonkonogi tonkonogi ADJ bam-1807 651 32 m. m. NOUN bam-1807 651 33 ultra ultra ADJ bam-1807 651 34 - - ADJ bam-1807 651 35 endurance endurance ADJ bam-1807 651 36 exercise exercise NOUN bam-1807 651 37 increases increase VERB bam-1807 651 38 the the DET bam-1807 651 39 production production NOUN bam-1807 651 40 of of ADP bam-1807 651 41 reactive reactive ADJ bam-1807 651 42 oxygen oxygen NOUN bam-1807 651 43 pecies pecie NOUN bam-1807 651 44 in in ADP bam-1807 651 45 isolated isolated ADJ bam-1807 651 46 mitochondria mitochondria NOUN bam-1807 651 47 from from ADP bam-1807 651 48 human human ADJ bam-1807 651 49 skeletal skeletal ADJ bam-1807 651 50 muscle muscle NOUN bam-1807 651 51 . . PUNCT bam-1807 652 1 j j PROPN bam-1807 652 2 .appl .appl PROPN bam-1807 652 3 . . PUNCT bam-1807 652 4 physiol physiol PROPN bam-1807 652 5 . . PUNCT bam-1807 653 1 2010 2010 NUM bam-1807 653 2 jan jan PROPN bam-1807 653 3 28 28 NUM bam-1807 653 4 . . PUNCT bam-1807 654 1 [ [ X bam-1807 654 2 epub epub NOUN bam-1807 654 3 ahead ahead ADV bam-1807 654 4 of of ADP bam-1807 654 5 print print NOUN bam-1807 654 6 ] ] PUNCT bam-1807 655 1 [ [ X bam-1807 655 2 94 94 X bam-1807 655 3 ] ] X bam-1807 655 4 sakuma sakuma PROPN bam-1807 655 5 k k PROPN bam-1807 655 6 , , PUNCT bam-1807 655 7 yamaguchi yamaguchi PROPN bam-1807 655 8 a.molecular a.molecular ADJ bam-1807 655 9 mechanisms mechanism NOUN bam-1807 655 10 in in ADP bam-1807 655 11 aging age VERB bam-1807 655 12 and and CCONJ bam-1807 655 13 current current ADJ bam-1807 655 14 strategies strategy NOUN bam-1807 655 15 to to PART bam-1807 655 16 counteract counteract VERB bam-1807 655 17 sarcopenia.curr sarcopenia.curr NOUN bam-1807 655 18 . . PUNCT bam-1807 655 19 aging age VERB bam-1807 655 20 sci sci PROPN bam-1807 655 21 . . PROPN bam-1807 656 1 2010 2010 NUM bam-1807 656 2 feb feb NOUN bam-1807 656 3 17 17 NUM bam-1807 656 4 . . PUNCT bam-1807 657 1 [ [ X bam-1807 657 2 epub epub NOUN bam-1807 657 3 ahead ahead ADV bam-1807 657 4 of of ADP bam-1807 657 5 print print NOUN bam-1807 657 6 ] ] PUNCT bam-1807 658 1 [ [ X bam-1807 658 2 95 95 NUM bam-1807 658 3 ] ] PUNCT bam-1807 658 4 salmons salmon NOUN bam-1807 658 5 s. s. PROPN bam-1807 658 6 muscle muscle PROPN bam-1807 658 7 damage damage NOUN bam-1807 658 8 . . PUNCT bam-1807 659 1 basic basic ADJ bam-1807 659 2 appl appl NOUN bam-1807 659 3 myol myol NOUN bam-1807 659 4 1994 1994 NUM bam-1807 659 5 ; ; PUNCT bam-1807 659 6 4 4 NUM bam-1807 659 7 : : SYM bam-1807 659 8 1 1 NUM bam-1807 659 9 - - SYM bam-1807 659 10 438 438 NUM bam-1807 660 1 [ [ X bam-1807 660 2 96 96 NUM bam-1807 660 3 ] ] X bam-1807 660 4 sandri sandri PROPN bam-1807 660 5 m m PROPN bam-1807 660 6 , , PUNCT bam-1807 660 7 carraro carraro NOUN bam-1807 660 8 u. u. NOUN bam-1807 660 9 apoptosis apoptosis NOUN bam-1807 660 10 of of ADP bam-1807 660 11 skeletal skeletal ADJ bam-1807 660 12 muscles muscle NOUN bam-1807 660 13 during during ADP bam-1807 660 14 development development NOUN bam-1807 660 15 and and CCONJ bam-1807 660 16 disease disease NOUN bam-1807 660 17 . . PUNCT bam-1807 661 1 int int NOUN bam-1807 661 2 . . PUNCT bam-1807 662 1 j. j. PROPN bam-1807 662 2 biochem biochem PROPN bam-1807 662 3 . . PUNCT bam-1807 663 1 cell cell NOUN bam-1807 663 2 biol biol PROPN bam-1807 663 3 . . PUNCT bam-1807 664 1 1999;31:1373 1999;31:1373 NUM bam-1807 664 2 - - SYM bam-1807 664 3 1390 1390 NUM bam-1807 664 4 . . PUNCT bam-1807 665 1 [ [ X bam-1807 665 2 97 97 NUM bam-1807 665 3 ] ] X bam-1807 665 4 sandri sandri PROPN bam-1807 665 5 m m PROPN bam-1807 665 6 , , PUNCT bam-1807 665 7 sandri sandri ADJ bam-1807 665 8 c c NOUN bam-1807 665 9 , , PUNCT bam-1807 665 10 gilbert gilbert PROPN bam-1807 665 11 a a PROPN bam-1807 665 12 , , PUNCT bam-1807 665 13 skurk skurk NOUN bam-1807 665 14 c c PROPN bam-1807 665 15 , , PUNCT bam-1807 665 16 calabria calabria PROPN bam-1807 665 17 e e PROPN bam-1807 665 18 , , PUNCT bam-1807 665 19 picard picard PROPN bam-1807 665 20 a a PRON bam-1807 665 21 , , PUNCT bam-1807 665 22 walsh walsh PROPN bam-1807 665 23 k k PROPN bam-1807 665 24 , , PUNCT bam-1807 665 25 schiaffino schiaffino PROPN bam-1807 665 26 s s PROPN bam-1807 665 27 , , PUNCT bam-1807 665 28 lecker lecker NOUN bam-1807 665 29 sh sh PROPN bam-1807 665 30 , , PUNCT bam-1807 665 31 goldberg goldberg PROPN bam-1807 665 32 al al PROPN bam-1807 665 33 . . PROPN bam-1807 666 1 foxo foxo PROPN bam-1807 666 2 transcription transcription NOUN bam-1807 666 3 factors factor NOUN bam-1807 666 4 induce induce VERB bam-1807 666 5 the the DET bam-1807 666 6 atrophy atrophy NOUN bam-1807 666 7 - - PUNCT bam-1807 666 8 related relate VERB bam-1807 666 9 ubiquitin ubiquitin NOUN bam-1807 666 10 ligase ligase NOUN bam-1807 666 11 atrogin-1 atrogin-1 NUM bam-1807 666 12 and and CCONJ bam-1807 666 13 cause cause VERB bam-1807 666 14 skeletal skeletal ADJ bam-1807 666 15 muscle muscle NOUN bam-1807 666 16 atrophy atrophy NOUN bam-1807 666 17 . . PUNCT bam-1807 667 1 cell cell NOUN bam-1807 667 2 . . PUNCT bam-1807 668 1 2004;117:399 2004;117:399 NUM bam-1807 668 2 - - SYM bam-1807 668 3 412 412 NUM bam-1807 668 4 . . PUNCT bam-1807 669 1 [ [ X bam-1807 669 2 98 98 NUM bam-1807 669 3 ] ] X bam-1807 669 4 sandri sandri ADJ bam-1807 669 5 m. m. NOUN bam-1807 669 6 , , PUNCT bam-1807 669 7 signaling signal VERB bam-1807 669 8 in in ADP bam-1807 669 9 muscle muscle NOUN bam-1807 669 10 atrophy atrophy NOUN bam-1807 669 11 and and CCONJ bam-1807 669 12 hypertrophy hypertrophy NOUN bam-1807 669 13 , , PUNCT bam-1807 669 14 physiology physiology NOUN bam-1807 669 15 2008 2008 NUM bam-1807 669 16 ; ; PUNCT bam-1807 669 17 23 23 NUM bam-1807 669 18 : : PUNCT bam-1807 669 19 160–170 160–170 NUM bam-1807 669 20 . . PUNCT bam-1807 670 1 [ [ X bam-1807 670 2 99 99 NUM bam-1807 670 3 ] ] X bam-1807 670 4 scheele scheele PROPN bam-1807 670 5 c c PROPN bam-1807 670 6 , , PUNCT bam-1807 670 7 nielsen nielsen PROPN bam-1807 670 8 s s PROPN bam-1807 670 9 , , PUNCT bam-1807 670 10 pedersen pedersen PROPN bam-1807 670 11 bk bk PROPN bam-1807 670 12 . . PUNCT bam-1807 671 1 ros ros PROPN bam-1807 671 2 and and CCONJ bam-1807 671 3 myokines myokine NOUN bam-1807 671 4 promote promote VERB bam-1807 671 5 muscle muscle NOUN bam-1807 671 6 adaptation adaptation NOUN bam-1807 671 7 to to PART bam-1807 671 8 exercise exercise VERB bam-1807 671 9 . . PUNCT bam-1807 672 1 trends trend NOUN bam-1807 672 2 endocrinol endocrinol VERB bam-1807 672 3 . . PUNCT bam-1807 673 1 metab metab NOUN bam-1807 673 2 . . PUNCT bam-1807 674 1 2009 2009 NUM bam-1807 674 2 ; ; PUNCT bam-1807 674 3 20:95 20:95 NUM bam-1807 674 4 - - SYM bam-1807 674 5 99 99 NUM bam-1807 674 6 . . PUNCT bam-1807 675 1 [ [ X bam-1807 675 2 100 100 NUM bam-1807 675 3 ] ] X bam-1807 675 4 schiaffino schiaffino PROPN bam-1807 675 5 s s PROPN bam-1807 675 6 , , PUNCT bam-1807 675 7 sandri sandri PROPN bam-1807 675 8 m m PROPN bam-1807 675 9 , , PUNCT bam-1807 675 10 murgia murgia PROPN bam-1807 675 11 m. m. PROPN bam-1807 675 12 activitydependent activitydependent PROPN bam-1807 675 13 signaling signal VERB bam-1807 675 14 pathways pathway NOUN bam-1807 675 15 controlling control VERB bam-1807 675 16 muscle muscle NOUN bam-1807 675 17 diversity diversity NOUN bam-1807 675 18 and and CCONJ bam-1807 675 19 plasticity plasticity NOUN bam-1807 675 20 . . PUNCT bam-1807 676 1 physiology physiology NOUN bam-1807 676 2 2007 2007 NUM bam-1807 676 3 ; ; PUNCT bam-1807 676 4 22:269 22:269 NUM bam-1807 676 5 - - SYM bam-1807 676 6 278 278 NUM bam-1807 676 7 . . PUNCT bam-1807 677 1 [ [ X bam-1807 677 2 101 101 NUM bam-1807 677 3 ] ] PUNCT bam-1807 677 4 schmitt schmitt PROPN bam-1807 677 5 b b PROPN bam-1807 677 6 , , PUNCT bam-1807 677 7 flück flück PROPN bam-1807 677 8 m m PROPN bam-1807 677 9 , , PUNCT bam-1807 677 10 décombaz décombaz PROPN bam-1807 677 11 j j PROPN bam-1807 677 12 , , PUNCT bam-1807 677 13 kreis kreis PROPN bam-1807 677 14 r r PROPN bam-1807 677 15 , , PUNCT bam-1807 677 16 boesch boesch PROPN bam-1807 677 17 c c PROPN bam-1807 677 18 , , PUNCT bam-1807 677 19 wittwer wittwer PROPN bam-1807 677 20 m m PROPN bam-1807 677 21 , , PUNCT bam-1807 677 22 graber graber PROPN bam-1807 677 23 f f PROPN bam-1807 677 24 , , PUNCT bam-1807 677 25 vogt vogt PROPN bam-1807 677 26 m m PROPN bam-1807 677 27 , , PUNCT bam-1807 677 28 howald howald PROPN bam-1807 677 29 h h NOUN bam-1807 677 30 , , PUNCT bam-1807 677 31 hoppeler hoppeler PROPN bam-1807 677 32 h. h. PROPN bam-1807 677 33 transcriptional transcriptional ADJ bam-1807 677 34 adaptations adaptation NOUN bam-1807 677 35 of of ADP bam-1807 677 36 lipid lipid ADJ bam-1807 677 37 metabolism metabolism NOUN bam-1807 677 38 in in ADP bam-1807 677 39 tibialis tibialis PROPN bam-1807 677 40 anterior anterior ADJ bam-1807 677 41 muscle muscle NOUN bam-1807 677 42 of of ADP bam-1807 677 43 endurance endurance NOUN bam-1807 677 44 - - PUNCT bam-1807 677 45 trained train VERB bam-1807 677 46 athletes athlete NOUN bam-1807 677 47 . . PUNCT bam-1807 677 48 physiol physiol PROPN bam-1807 677 49 . . PUNCT bam-1807 678 1 genomics genomic NOUN bam-1807 678 2 2003 2003 NUM bam-1807 678 3 ; ; PUNCT bam-1807 678 4 15:148–157 15:148–157 NUM bam-1807 678 5 . . PUNCT bam-1807 679 1 [ [ X bam-1807 679 2 102 102 NUM bam-1807 679 3 ] ] X bam-1807 679 4 schmutz schmutz PROPN bam-1807 679 5 s s PROPN bam-1807 679 6 , , PUNCT bam-1807 679 7 däpp däpp PROPN bam-1807 679 8 c c NOUN bam-1807 679 9 , , PUNCT bam-1807 679 10 wittwer wittwer PROPN bam-1807 679 11 m m PROPN bam-1807 679 12 , , PUNCT bam-1807 679 13 vogt vogt PROPN bam-1807 679 14 m m PROPN bam-1807 679 15 , , PUNCT bam-1807 679 16 hoppeler hoppeler ADJ bam-1807 679 17 h h PROPN bam-1807 679 18 , , PUNCT bam-1807 679 19 flück flück PROPN bam-1807 679 20 m. m. NOUN bam-1807 679 21 endurance endurance NOUN bam-1807 679 22 training training NOUN bam-1807 679 23 modulates modulate VERB bam-1807 679 24 the the DET bam-1807 679 25 muscular muscular ADJ bam-1807 679 26 transcriptome transcriptome ADJ bam-1807 679 27 response response NOUN bam-1807 679 28 to to ADP bam-1807 679 29 acute acute ADJ bam-1807 679 30 exercise exercise NOUN bam-1807 679 31 . . PUNCT bam-1807 680 1 pflugers pfluger NOUN bam-1807 680 2 arch arch VERB bam-1807 680 3 . . PUNCT bam-1807 681 1 2006 2006 NUM bam-1807 681 2 ; ; PUNCT bam-1807 681 3 451:678–687 451:678–687 NUM bam-1807 681 4 . . PUNCT bam-1807 682 1 [ [ X bam-1807 682 2 103 103 NUM bam-1807 682 3 ] ] X bam-1807 682 4 schuelke schuelke PROPN bam-1807 682 5 m m PROPN bam-1807 682 6 , , PUNCT bam-1807 682 7 wagner wagner PROPN bam-1807 682 8 kr kr PROPN bam-1807 682 9 , , PUNCT bam-1807 682 10 stolz stolz PROPN bam-1807 682 11 le le X bam-1807 682 12 , , PUNCT bam-1807 682 13 hubner hubner NOUN bam-1807 682 14 c c PROPN bam-1807 682 15 , , PUNCT bam-1807 682 16 riebel riebel NOUN bam-1807 682 17 t t PROPN bam-1807 682 18 , , PUNCT bam-1807 682 19 komen komen PROPN bam-1807 682 20 w w PROPN bam-1807 682 21 , , PUNCT bam-1807 682 22 braun braun PROPN bam-1807 682 23 t t PROPN bam-1807 682 24 , , PUNCT bam-1807 682 25 tobin tobin PROPN bam-1807 682 26 jf jf PROPN bam-1807 682 27 , , PUNCT bam-1807 682 28 lee lee PROPN bam-1807 682 29 sj sj PROPN bam-1807 682 30 . . PUNCT bam-1807 682 31 myostatin myostatin PROPN bam-1807 682 32 mutation mutation NOUN bam-1807 682 33 associated associate VERB bam-1807 682 34 with with ADP bam-1807 682 35 gross gross ADJ bam-1807 682 36 muscle muscle NOUN bam-1807 682 37 hypertrophy hypertrophy NOUN bam-1807 682 38 in in ADP bam-1807 682 39 a a DET bam-1807 682 40 child child NOUN bam-1807 682 41 . . PUNCT bam-1807 683 1 n. n. PROPN bam-1807 683 2 engl engl PROPN bam-1807 683 3 . . PUNCT bam-1807 684 1 j. j. PROPN bam-1807 684 2 med med PROPN bam-1807 684 3 . . PUNCT bam-1807 684 4 2004 2004 NUM bam-1807 684 5 ; ; PUNCT bam-1807 684 6 350 350 NUM bam-1807 684 7 : : SYM bam-1807 684 8 2682–2688 2682–2688 NUM bam-1807 684 9 . . PUNCT bam-1807 685 1 [ [ X bam-1807 685 2 104 104 X bam-1807 685 3 ] ] X bam-1807 685 4 selman selman PROPN bam-1807 685 5 c c PROPN bam-1807 685 6 , , PUNCT bam-1807 685 7 mclaren mclaren PROPN bam-1807 685 8 js js PROPN bam-1807 685 9 , , PUNCT bam-1807 685 10 collins collins PROPN bam-1807 685 11 ar ar PROPN bam-1807 685 12 , , PUNCT bam-1807 685 13 duthie duthie PROPN bam-1807 685 14 gg gg PROPN bam-1807 685 15 , , PUNCT bam-1807 685 16 speakman speakman PROPN bam-1807 685 17 jr jr PROPN bam-1807 685 18 . . PROPN bam-1807 685 19 antioxidant antioxidant ADJ bam-1807 685 20 enzyme enzyme NOUN bam-1807 685 21 activities activity NOUN bam-1807 685 22 , , PUNCT bam-1807 685 23 lipid lipid NOUN bam-1807 685 24 peroxidation peroxidation NOUN bam-1807 685 25 , , PUNCT bam-1807 685 26 and and CCONJ bam-1807 685 27 dna dna PROPN bam-1807 685 28 oxidative oxidative ADJ bam-1807 685 29 damage damage NOUN bam-1807 685 30 : : PUNCT bam-1807 685 31 the the DET bam-1807 685 32 effects effect NOUN bam-1807 685 33 of of ADP bam-1807 685 34 short short ADJ bam-1807 685 35 - - PUNCT bam-1807 685 36 term term NOUN bam-1807 685 37 voluntary voluntary ADJ bam-1807 685 38 wheel wheel NOUN bam-1807 685 39 running run VERB bam-1807 685 40 arch arch NOUN bam-1807 685 41 . . PUNCT bam-1807 686 1 biochem biochem PROPN bam-1807 686 2 . . PUNCT bam-1807 687 1 biophys biophy NOUN bam-1807 687 2 . . PUNCT bam-1807 688 1 2002 2002 NUM bam-1807 688 2 ; ; PUNCT bam-1807 688 3 401:255–261 401:255–261 NUM bam-1807 688 4 . . PUNCT bam-1807 689 1 [ [ X bam-1807 689 2 105 105 NUM bam-1807 689 3 ] ] PUNCT bam-1807 689 4 sies sies PROPN bam-1807 689 5 h h NOUN bam-1807 689 6 ( ( PUNCT bam-1807 689 7 1991 1991 NUM bam-1807 689 8 ) ) PUNCT bam-1807 689 9 oxidative oxidative ADJ bam-1807 689 10 stress stress NOUN bam-1807 689 11 . . PUNCT bam-1807 690 1 ii ii PROPN bam-1807 690 2 . . PUNCT bam-1807 691 1 oxidants oxidant NOUN bam-1807 691 2 and and CCONJ bam-1807 691 3 antioxidants antioxidant NOUN bam-1807 691 4 . . PUNCT bam-1807 692 1 academic academic ADJ bam-1807 692 2 press press NOUN bam-1807 692 3 , , PUNCT bam-1807 692 4 london london PROPN bam-1807 693 1 [ [ X bam-1807 693 2 106 106 NUM bam-1807 693 3 ] ] X bam-1807 693 4 sirvent sirvent PROPN bam-1807 693 5 p p X bam-1807 693 6 , , PUNCT bam-1807 693 7 mercier mercier PROPN bam-1807 693 8 j j PROPN bam-1807 693 9 , , PUNCT bam-1807 693 10 lacampagne lacampagne X bam-1807 693 11 a.new a.new ADJ bam-1807 693 12 insights insight NOUN bam-1807 693 13 into into ADP bam-1807 693 14 mechanisms mechanism NOUN bam-1807 693 15 of of ADP bam-1807 693 16 statin statin PROPN bam-1807 693 17 - - PUNCT bam-1807 693 18 associated associate VERB bam-1807 693 19 myotoxicity myotoxicity NOUN bam-1807 693 20 . . PUNCT bam-1807 694 1 curr curr PROPN bam-1807 694 2 . . PUNCT bam-1807 695 1 opin opin NOUN bam-1807 695 2 . . PUNCT bam-1807 696 1 pharmacol pharmacol PROPN bam-1807 696 2 . . PROPN bam-1807 696 3 2008 2008 NUM bam-1807 696 4 ; ; PUNCT bam-1807 696 5 8:333 8:333 NUM bam-1807 696 6 - - SYM bam-1807 696 7 338 338 NUM bam-1807 696 8 . . PUNCT bam-1807 697 1 [ [ X bam-1807 697 2 107 107 NUM bam-1807 697 3 ] ] X bam-1807 697 4 siu siu NOUN bam-1807 697 5 pm pm NOUN bam-1807 697 6 , , PUNCT bam-1807 697 7 bryner bryner X bam-1807 697 8 rw rw NOUN bam-1807 697 9 , , PUNCT bam-1807 697 10 martyn martyn PROPN bam-1807 697 11 jk jk PROPN bam-1807 697 12 , , PUNCT bam-1807 697 13 alway alway ADV bam-1807 697 14 se se PROPN bam-1807 697 15 . . PUNCT bam-1807 698 1 apoptotic apoptotic ADJ bam-1807 698 2 adaptations adaptation NOUN bam-1807 698 3 from from ADP bam-1807 698 4 exercise exercise NOUN bam-1807 698 5 training training NOUN bam-1807 698 6 in in ADP bam-1807 698 7 skeletal skeletal ADJ bam-1807 698 8 and and CCONJ bam-1807 698 9 cardiac cardiac ADJ bam-1807 698 10 muscles muscle NOUN bam-1807 698 11 . . PUNCT bam-1807 699 1 faseb faseb PROPN bam-1807 699 2 j. j. PROPN bam-1807 699 3 2004 2004 PROPN bam-1807 699 4 ; ; PUNCT bam-1807 699 5 18:1150 18:1150 NUM bam-1807 699 6 - - SYM bam-1807 699 7 1152 1152 NUM bam-1807 699 8 . . PUNCT bam-1807 700 1 [ [ X bam-1807 700 2 108 108 NUM bam-1807 700 3 ] ] X bam-1807 700 4 solomon solomon PROPN bam-1807 700 5 am be AUX bam-1807 700 6 , , PUNCT bam-1807 700 7 bouloux bouloux ADJ bam-1807 700 8 pm pm NOUN bam-1807 700 9 . . PUNCT bam-1807 701 1 modifying modify VERB bam-1807 701 2 muscle muscle NOUN bam-1807 701 3 mass mass NOUN bam-1807 701 4 the the DET bam-1807 701 5 endocrine endocrine PROPN bam-1807 701 6 perspective perspective NOUN bam-1807 701 7 . . PUNCT bam-1807 702 1 j. j. PROPN bam-1807 702 2 endocrinol endocrinol PROPN bam-1807 702 3 . . PUNCT bam-1807 703 1 2006 2006 NUM bam-1807 703 2 ; ; PUNCT bam-1807 703 3 191:349 191:349 NUM bam-1807 703 4 - - PUNCT bam-1807 703 5 360 360 NUM bam-1807 703 6 . . PUNCT bam-1807 704 1 [ [ X bam-1807 704 2 109 109 NUM bam-1807 704 3 ] ] PUNCT bam-1807 704 4 stanfel stanfel PROPN bam-1807 704 5 mn mn PROPN bam-1807 704 6 , , PUNCT bam-1807 704 7 shamieh shamieh PROPN bam-1807 704 8 ls ls PROPN bam-1807 704 9 , , PUNCT bam-1807 704 10 kaeberlein kaeberlein PROPN bam-1807 704 11 m m PROPN bam-1807 704 12 , , PUNCT bam-1807 704 13 kennedy kennedy PROPN bam-1807 704 14 bk bk PROPN bam-1807 704 15 . . PUNCT bam-1807 705 1 the the DET bam-1807 705 2 tor tor NOUN bam-1807 705 3 pathway pathway NOUN bam-1807 705 4 comes come VERB bam-1807 705 5 of of ADP bam-1807 705 6 age.biochim age.biochim DET bam-1807 705 7 biophys biophys PROPN bam-1807 705 8 acta acta PROPN bam-1807 705 9 . . PUNCT bam-1807 706 1 2009;1790:10671074 2009;1790:10671074 NUM bam-1807 706 2 . . PUNCT bam-1807 707 1 [ [ X bam-1807 707 2 110 110 NUM bam-1807 707 3 ] ] X bam-1807 707 4 strijk strijk PROPN bam-1807 707 5 je je PROPN bam-1807 707 6 , , PUNCT bam-1807 707 7 proper proper ADJ bam-1807 707 8 ki ki PROPN bam-1807 707 9 , , PUNCT bam-1807 707 10 van van PROPN bam-1807 707 11 der der PROPN bam-1807 707 12 beek beek PROPN bam-1807 707 13 aj aj PROPN bam-1807 707 14 , , PUNCT bam-1807 707 15 van van PROPN bam-1807 707 16 mechelen mechelen PROPN bam-1807 707 17 w. w. PROPN bam-1807 707 18 the the DET bam-1807 707 19 vital@work vital@work NOUN bam-1807 707 20 study study NOUN bam-1807 707 21 . . PUNCT bam-1807 708 1 the the DET bam-1807 708 2 systematic systematic ADJ bam-1807 708 3 development development NOUN bam-1807 708 4 of of ADP bam-1807 708 5 a a DET bam-1807 708 6 lifestyle lifestyle NOUN bam-1807 708 7 intervention intervention NOUN bam-1807 708 8 to to PART bam-1807 708 9 improve improve VERB bam-1807 708 10 older old ADJ bam-1807 708 11 workers worker NOUN bam-1807 708 12 ' ' PART bam-1807 708 13 vitality vitality NOUN bam-1807 708 14 and and CCONJ bam-1807 708 15 the the DET bam-1807 708 16 design design NOUN bam-1807 708 17 of of ADP bam-1807 708 18 a a DET bam-1807 708 19 randomised randomised ADJ bam-1807 708 20 controlled control VERB bam-1807 708 21 trial trial NOUN bam-1807 708 22 evaluating evaluate VERB bam-1807 708 23 this this DET bam-1807 708 24 intervention intervention NOUN bam-1807 708 25 . . PUNCT bam-1807 709 1 bmc bmc ADJ bam-1807 709 2 public public ADJ bam-1807 709 3 health health NOUN bam-1807 709 4 . . PUNCT bam-1807 710 1 2009;10:408 2009;10:408 X bam-1807 710 2 . . PUNCT bam-1807 711 1 [ [ X bam-1807 711 2 111 111 NUM bam-1807 711 3 ] ] PUNCT bam-1807 711 4 takekura takekura NOUN bam-1807 711 5 h h NOUN bam-1807 711 6 , , PUNCT bam-1807 711 7 fujinami fujinami ADJ bam-1807 711 8 n n CCONJ bam-1807 711 9 , , PUNCT bam-1807 711 10 nishizawa nishizawa PROPN bam-1807 711 11 t t PROPN bam-1807 711 12 , , PUNCT bam-1807 711 13 ogasawara ogasawara PROPN bam-1807 711 14 h h NOUN bam-1807 711 15 , , PUNCT bam-1807 711 16 kasuga kasuga ADJ bam-1807 711 17 n. n. NOUN bam-1807 711 18 eccentric eccentric ADJ bam-1807 711 19 exerciseinduced exerciseinduce VERB bam-1807 711 20 morphological morphological ADJ bam-1807 711 21 changes change NOUN bam-1807 711 22 in in ADP bam-1807 711 23 the the DET bam-1807 711 24 membrane membrane NOUN bam-1807 711 25 systems system NOUN bam-1807 711 26 involved involve VERB bam-1807 711 27 in in ADP bam-1807 711 28 excitationcontraction excitationcontraction NOUN bam-1807 711 29 coupling coupling NOUN bam-1807 711 30 in in ADP bam-1807 711 31 rat rat NOUN bam-1807 711 32 skeletal skeletal ADJ bam-1807 711 33 muscle muscle NOUN bam-1807 711 34 . . PUNCT bam-1807 712 1 j. j. PROPN bam-1807 712 2 physiol physiol PROPN bam-1807 712 3 . . PUNCT bam-1807 713 1 2001 2001 NUM bam-1807 713 2 ; ; PUNCT bam-1807 713 3 533:571 533:571 NUM bam-1807 713 4 - - SYM bam-1807 713 5 583 583 NUM bam-1807 713 6 . . PUNCT bam-1807 714 1 [ [ X bam-1807 714 2 112 112 NUM bam-1807 714 3 ] ] X bam-1807 714 4 terada terada PROPN bam-1807 714 5 s s PROPN bam-1807 714 6 , , PUNCT bam-1807 714 7 yokozeki yokozeki PROPN bam-1807 714 8 t t PROPN bam-1807 714 9 , , PUNCT bam-1807 714 10 kawanaka kawanaka PROPN bam-1807 714 11 k k PROPN bam-1807 714 12 , , PUNCT bam-1807 714 13 ogawa ogawa PROPN bam-1807 714 14 k k PROPN bam-1807 714 15 , , PUNCT bam-1807 714 16 higuchi higuchi PROPN bam-1807 714 17 m m PROPN bam-1807 714 18 , , PUNCT bam-1807 714 19 ezaki ezaki ADJ bam-1807 714 20 o o NOUN bam-1807 714 21 , , PUNCT bam-1807 714 22 tabata tabata NOUN bam-1807 714 23 i. i. NOUN bam-1807 714 24 effects effect NOUN bam-1807 714 25 of of ADP bam-1807 714 26 highintensity highintensity NOUN bam-1807 714 27 swimming swimming NOUN bam-1807 714 28 training training NOUN bam-1807 714 29 on on ADP bam-1807 714 30 glut-4 glut-4 PROPN bam-1807 714 31 and and CCONJ bam-1807 714 32 glucose glucose NOUN bam-1807 714 33 transport transport NOUN bam-1807 714 34 activity activity NOUN bam-1807 714 35 in in ADP bam-1807 714 36 rat rat NOUN bam-1807 714 37 skeletal skeletal ADJ bam-1807 714 38 muscle muscle NOUN bam-1807 714 39 . . PUNCT bam-1807 715 1 j. j. PROPN bam-1807 715 2 appl appl PROPN bam-1807 715 3 . . PUNCT bam-1807 715 4 physiol physiol PROPN bam-1807 715 5 . . PUNCT bam-1807 716 1 2001 2001 NUM bam-1807 716 2 ; ; PUNCT bam-1807 716 3 90 90 NUM bam-1807 716 4 : : PUNCT bam-1807 716 5 2019–2024 2019–2024 NUM bam-1807 716 6 . . PUNCT bam-1807 717 1 [ [ X bam-1807 717 2 113 113 NUM bam-1807 717 3 ] ] PUNCT bam-1807 717 4 tillin tillin PROPN bam-1807 717 5 na na PROPN bam-1807 717 6 , , PUNCT bam-1807 717 7 bishop bishop PROPN bam-1807 717 8 d. d. PROPN bam-1807 717 9 factors factor NOUN bam-1807 717 10 modulating modulate VERB bam-1807 717 11 postactivation postactivation NOUN bam-1807 717 12 potentiation potentiation NOUN bam-1807 717 13 and and CCONJ bam-1807 717 14 its its PRON bam-1807 717 15 effect effect NOUN bam-1807 717 16 on on ADP bam-1807 717 17 performance performance NOUN bam-1807 717 18 of of ADP bam-1807 717 19 subsequent subsequent ADJ bam-1807 717 20 explosive explosive ADJ bam-1807 717 21 activities activity NOUN bam-1807 717 22 . . PUNCT bam-1807 718 1 sports sport NOUN bam-1807 718 2 med med PROPN bam-1807 718 3 . . PUNCT bam-1807 718 4 2009 2009 NUM bam-1807 718 5 ; ; PUNCT bam-1807 718 6 39:147 39:147 NUM bam-1807 718 7 - - SYM bam-1807 718 8 166 166 NUM bam-1807 718 9 . . PUNCT bam-1807 719 1 [ [ X bam-1807 719 2 114 114 NUM bam-1807 719 3 ] ] X bam-1807 719 4 tipton tipton PROPN bam-1807 719 5 kd kd PROPN bam-1807 719 6 , , PUNCT bam-1807 719 7 rasmussen rasmussen PROPN bam-1807 719 8 bb bb PROPN bam-1807 719 9 , , PUNCT bam-1807 719 10 miller miller PROPN bam-1807 719 11 sl sl PROPN bam-1807 719 12 , , PUNCT bam-1807 719 13 wolf wolf PROPN bam-1807 719 14 se se PROPN bam-1807 719 15 , , PUNCT bam-1807 719 16 owens owens PROPN bam-1807 719 17 - - PUNCT bam-1807 719 18 stovall stovall PROPN bam-1807 719 19 sk sk PROPN bam-1807 719 20 , , PUNCT bam-1807 719 21 petrini petrini NOUN bam-1807 719 22 be be PROPN bam-1807 719 23 , , PUNCT bam-1807 719 24 wolfe wolfe PROPN bam-1807 719 25 rr rr PROPN bam-1807 719 26 timing timing NOUN bam-1807 719 27 of of ADP bam-1807 719 28 amino amino NOUN bam-1807 719 29 acid acid NOUN bam-1807 719 30 – – PUNCT bam-1807 719 31 carbohydrate carbohydrate NOUN bam-1807 719 32 ingestion ingestion NOUN bam-1807 719 33 alters alter VERB bam-1807 719 34 anabolic anabolic ADJ bam-1807 719 35 response response NOUN bam-1807 719 36 of of ADP bam-1807 719 37 muscle muscle NOUN bam-1807 719 38 to to ADP bam-1807 719 39 resistance resistance NOUN bam-1807 719 40 exercise exercise NOUN bam-1807 719 41 . . PUNCT bam-1807 720 1 am be AUX bam-1807 720 2 . . PUNCT bam-1807 721 1 j. j. PROPN bam-1807 721 2 physiol physiol PROPN bam-1807 721 3 2001 2001 NUM bam-1807 721 4 ; ; PUNCT bam-1807 721 5 281 281 NUM bam-1807 721 6 : : PUNCT bam-1807 721 7 e197–206 e197–206 PROPN bam-1807 721 8 . . PUNCT bam-1807 722 1 [ [ X bam-1807 722 2 115 115 NUM bam-1807 722 3 ] ] SYM bam-1807 722 4 tskhovrebova tskhovrebova PROPN bam-1807 722 5 , , PUNCT bam-1807 722 6 l. l. PROPN bam-1807 722 7 and and CCONJ bam-1807 722 8 trinick trinick PROPN bam-1807 722 9 , , PUNCT bam-1807 722 10 j. j. PROPN bam-1807 722 11 titin titin PROPN bam-1807 722 12 : : PUNCT bam-1807 722 13 properties property NOUN bam-1807 722 14 and and CCONJ bam-1807 722 15 family family NOUN bam-1807 722 16 relationships relationship NOUN bam-1807 722 17 . . PUNCT bam-1807 723 1 nat nat PROPN bam-1807 723 2 . . PUNCT bam-1807 724 1 rev rev PROPN bam-1807 724 2 . . PROPN bam-1807 724 3 mol mol PROPN bam-1807 724 4 . . PROPN bam-1807 724 5 cell cell PROPN bam-1807 724 6 biol biol PROPN bam-1807 724 7 . . PUNCT bam-1807 725 1 2003 2003 NUM bam-1807 725 2 ; ; PUNCT bam-1807 725 3 4 4 NUM bam-1807 725 4 : : PUNCT bam-1807 725 5 679–689 679–689 NUM bam-1807 725 6 . . PUNCT bam-1807 726 1 [ [ X bam-1807 726 2 116 116 X bam-1807 726 3 ] ] X bam-1807 726 4 ukropec ukropec PROPN bam-1807 726 5 j j PROPN bam-1807 726 6 , , PUNCT bam-1807 726 7 ukropcova ukropcova PROPN bam-1807 726 8 b b NUM bam-1807 726 9 , , PUNCT bam-1807 726 10 kurdiova kurdiova PROPN bam-1807 726 11 t t PROPN bam-1807 726 12 , , PUNCT bam-1807 726 13 gasperikova gasperikova X bam-1807 726 14 d d NOUN bam-1807 726 15 , , PUNCT bam-1807 726 16 klimes klime VERB bam-1807 726 17 i. i. PROPN bam-1807 726 18 adipose adipose NOUN bam-1807 726 19 tissue tissue NOUN bam-1807 726 20 and and CCONJ bam-1807 726 21 skeletal skeletal ADJ bam-1807 726 22 muscle muscle NOUN bam-1807 726 23 plasticity plasticity NOUN bam-1807 726 24 modulates modulate VERB bam-1807 726 25 metabolic metabolic NOUN bam-1807 726 26 health health NOUN bam-1807 726 27 . . PUNCT bam-1807 727 1 arch arch PROPN bam-1807 727 2 . . PUNCT bam-1807 728 1 physiol physiol PROPN bam-1807 728 2 . . PUNCT bam-1807 729 1 biochem biochem PROPN bam-1807 729 2 .. .. PUNCT bam-1807 729 3 2008 2008 NUM bam-1807 729 4 ; ; PUNCT bam-1807 729 5 114:357 114:357 NOUN bam-1807 729 6 - - PUNCT bam-1807 729 7 368 368 NUM bam-1807 729 8 . . PUNCT bam-1807 730 1 the the DET bam-1807 730 2 exercised exercise VERB bam-1807 730 3 skeletal skeletal ADJ bam-1807 730 4 muscle muscle NOUN bam-1807 730 5 european european PROPN bam-1807 730 6 journal journal PROPN bam-1807 730 7 translational translational ADJ bam-1807 730 8 myology myology NOUN bam-1807 730 9 myology myology NOUN bam-1807 730 10 reviews review VERB bam-1807 730 11 20 20 NUM bam-1807 730 12 ( ( PUNCT bam-1807 730 13 3 3 NUM bam-1807 730 14 ): ): PUNCT bam-1807 730 15 105 105 NUM bam-1807 730 16 - - SYM bam-1807 730 17 120 120 NUM bam-1807 730 18 , , PUNCT bam-1807 730 19 2010 2010 NUM bam-1807 730 20 120 120 NUM bam-1807 731 1 [ [ X bam-1807 731 2 117 117 NUM bam-1807 731 3 ] ] X bam-1807 731 4 ventura ventura PROPN bam-1807 731 5 - - PUNCT bam-1807 731 6 clapier clapier NOUN bam-1807 731 7 r. r. PROPN bam-1807 731 8 exercise exercise PROPN bam-1807 731 9 training training NOUN bam-1807 731 10 , , PUNCT bam-1807 731 11 energy energy NOUN bam-1807 731 12 metabolism metabolism NOUN bam-1807 731 13 , , PUNCT bam-1807 731 14 and and CCONJ bam-1807 731 15 heart heart NOUN bam-1807 731 16 failure failure NOUN bam-1807 731 17 . . PUNCT bam-1807 732 1 appl appl PROPN bam-1807 732 2 . . PUNCT bam-1807 732 3 physiol physiol PROPN bam-1807 732 4 . . PUNCT bam-1807 733 1 nutr nutr PROPN bam-1807 733 2 . . PUNCT bam-1807 733 3 metab metab PROPN bam-1807 733 4 . . PUNCT bam-1807 734 1 2009 2009 NUM bam-1807 734 2 ; ; PUNCT bam-1807 734 3 34:336 34:336 NUM bam-1807 734 4 - - SYM bam-1807 734 5 339 339 NUM bam-1807 734 6 . . PUNCT bam-1807 735 1 [ [ X bam-1807 735 2 118 118 NUM bam-1807 735 3 ] ] PUNCT bam-1807 735 4 wackerhage wackerhage NOUN bam-1807 735 5 h h PROPN bam-1807 735 6 , , PUNCT bam-1807 735 7 ratkevicius ratkevicius PROPN bam-1807 735 8 a. a. NOUN bam-1807 735 9 signal signal PROPN bam-1807 735 10 transduction transduction NOUN bam-1807 735 11 pathways pathway NOUN bam-1807 735 12 that that PRON bam-1807 735 13 regulate regulate VERB bam-1807 735 14 muscle muscle NOUN bam-1807 735 15 growth growth NOUN bam-1807 735 16 , , PUNCT bam-1807 735 17 essays essay NOUN bam-1807 735 18 biochem biochem NOUN bam-1807 735 19 2008 2008 NUM bam-1807 735 20 ; ; PUNCT bam-1807 735 21 44 44 NUM bam-1807 735 22 : : SYM bam-1807 735 23 99 99 NUM bam-1807 735 24 - - SYM bam-1807 735 25 108 108 NUM bam-1807 735 26 . . PUNCT bam-1807 736 1 [ [ X bam-1807 736 2 119 119 NUM bam-1807 736 3 ] ] X bam-1807 736 4 wozniak wozniak PROPN bam-1807 736 5 ac ac PROPN bam-1807 736 6 , , PUNCT bam-1807 736 7 kong kong PROPN bam-1807 736 8 j j PROPN bam-1807 736 9 , , PUNCT bam-1807 736 10 bock bock NOUN bam-1807 736 11 e e NOUN bam-1807 736 12 , , PUNCT bam-1807 736 13 pilipowicz pilipowicz ADJ bam-1807 736 14 o o NOUN bam-1807 736 15 , , PUNCT bam-1807 736 16 anderson anderson PROPN bam-1807 736 17 je je PROPN bam-1807 736 18 . . PUNCT bam-1807 736 19 signaling signal VERB bam-1807 736 20 satellite satellite NOUN bam-1807 736 21 - - PUNCT bam-1807 736 22 cell cell NOUN bam-1807 736 23 activation activation NOUN bam-1807 736 24 in in ADP bam-1807 736 25 skeletal skeletal ADJ bam-1807 736 26 muscle muscle NOUN bam-1807 736 27 : : PUNCT bam-1807 736 28 markers marker NOUN bam-1807 736 29 , , PUNCT bam-1807 736 30 models model NOUN bam-1807 736 31 , , PUNCT bam-1807 736 32 stretch stretch NOUN bam-1807 736 33 , , PUNCT bam-1807 736 34 and and CCONJ bam-1807 736 35 potential potential ADJ bam-1807 736 36 alternate alternate ADJ bam-1807 736 37 pathways pathway NOUN bam-1807 736 38 . . PUNCT bam-1807 737 1 muscle muscle NOUN bam-1807 737 2 nerve nerve NOUN bam-1807 737 3 2005 2005 NUM bam-1807 737 4 ; ; PUNCT bam-1807 737 5 31:283–300 31:283–300 NUM bam-1807 737 6 . . PUNCT bam-1807 738 1 [ [ X bam-1807 738 2 120 120 NUM bam-1807 738 3 ] ] PUNCT bam-1807 738 4 wray wray PROPN bam-1807 738 5 dw dw PROPN bam-1807 738 6 , , PUNCT bam-1807 738 7 nishiyama nishiyama NOUN bam-1807 738 8 sk sk VERB bam-1807 738 9 , , PUNCT bam-1807 738 10 monnet monnet VERB bam-1807 738 11 a a DET bam-1807 738 12 , , PUNCT bam-1807 738 13 wary wary ADJ bam-1807 738 14 c c NOUN bam-1807 738 15 , , PUNCT bam-1807 738 16 duteil duteil NOUN bam-1807 738 17 ss ss PROPN bam-1807 738 18 , , PUNCT bam-1807 738 19 carlier carlier NOUN bam-1807 738 20 pg pg PROPN bam-1807 738 21 , , PUNCT bam-1807 738 22 richardson richardson PROPN bam-1807 738 23 rs rs PROPN bam-1807 738 24 . . PUNCT bam-1807 739 1 antioxidants antioxidant NOUN bam-1807 739 2 and and CCONJ bam-1807 739 3 aging aging NOUN bam-1807 739 4 : : PUNCT bam-1807 739 5 nmr nmr NOUN bam-1807 739 6 - - PUNCT bam-1807 739 7 based base VERB bam-1807 739 8 evidence evidence NOUN bam-1807 739 9 of of ADP bam-1807 739 10 improved improved ADJ bam-1807 739 11 skeletal skeletal ADJ bam-1807 739 12 muscle muscle NOUN bam-1807 739 13 perfusion perfusion NOUN bam-1807 739 14 and and CCONJ bam-1807 739 15 energetics energetic NOUN bam-1807 739 16 . . PUNCT bam-1807 740 1 am be AUX bam-1807 740 2 . . PUNCT bam-1807 741 1 j. j. PROPN bam-1807 741 2 physiol physiol PROPN bam-1807 741 3 . . PUNCT bam-1807 742 1 heart heart NOUN bam-1807 742 2 circ circ PROPN bam-1807 742 3 . . PUNCT bam-1807 743 1 physiol physiol PROPN bam-1807 743 2 . . PUNCT bam-1807 744 1 2009 2009 NUM bam-1807 744 2 ; ; PUNCT bam-1807 744 3 297 297 NUM bam-1807 744 4 : : PUNCT bam-1807 744 5 h1870 h1870 NOUN bam-1807 744 6 - - PUNCT bam-1807 744 7 h1875 h1875 PRON bam-1807 744 8 . . PUNCT bam-1807 745 1 [ [ X bam-1807 745 2 121 121 NUM bam-1807 745 3 ] ] PUNCT bam-1807 745 4 wullschleger wullschleger ADJ bam-1807 745 5 s s NOUN bam-1807 745 6 , , PUNCT bam-1807 745 7 loewith loewith ADJ bam-1807 745 8 r r PROPN bam-1807 745 9 , , PUNCT bam-1807 745 10 hall hall PROPN bam-1807 745 11 mn mn PROPN bam-1807 745 12 . . PROPN bam-1807 745 13 tor tor PROPN bam-1807 745 14 signaling signal VERB bam-1807 745 15 in in ADP bam-1807 745 16 growth growth NOUN bam-1807 745 17 and and CCONJ bam-1807 745 18 metabolism metabolism NOUN bam-1807 745 19 . . PUNCT bam-1807 746 1 cell cell NOUN bam-1807 746 2 2006 2006 NUM bam-1807 746 3 ; ; PUNCT bam-1807 746 4 124:471 124:471 NUM bam-1807 746 5 - - PUNCT bam-1807 746 6 484 484 NUM bam-1807 746 7 . . PUNCT bam-1807 747 1 [ [ X bam-1807 747 2 122 122 NUM bam-1807 747 3 ] ] X bam-1807 747 4 weibel weibel NOUN bam-1807 747 5 er er INTJ bam-1807 747 6 , , PUNCT bam-1807 747 7 physiology physiology NOUN bam-1807 747 8 : : PUNCT bam-1807 747 9 the the DET bam-1807 747 10 pitfalls pitfall NOUN bam-1807 747 11 of of ADP bam-1807 747 12 power power NOUN bam-1807 747 13 laws law NOUN bam-1807 747 14 , , PUNCT bam-1807 747 15 nature nature NOUN bam-1807 747 16 2002 2002 NUM bam-1807 747 17 ; ; PUNCT bam-1807 747 18 417 417 NUM bam-1807 747 19 : : PUNCT bam-1807 747 20 131 131 NUM bam-1807 747 21 - - SYM bam-1807 747 22 132 132 NUM bam-1807 747 23 . . PUNCT bam-1807 748 1 [ [ X bam-1807 748 2 123 123 NUM bam-1807 748 3 ] ] X bam-1807 748 4 yan yan PROPN bam-1807 748 5 z. z. PROPN bam-1807 748 6 exercise exercise PROPN bam-1807 748 7 , , PUNCT bam-1807 748 8 pgc-1alpha pgc-1alpha NOUN bam-1807 748 9 , , PUNCT bam-1807 748 10 and and CCONJ bam-1807 748 11 metabolic metabolic NOUN bam-1807 748 12 adaptation adaptation NOUN bam-1807 748 13 in in ADP bam-1807 748 14 skeletal skeletal ADJ bam-1807 748 15 muscle muscle NOUN bam-1807 748 16 . . PUNCT bam-1807 749 1 appl appl PROPN bam-1807 749 2 . . PUNCT bam-1807 749 3 physiol physiol PROPN bam-1807 749 4 . . PUNCT bam-1807 750 1 nutr nutr PROPN bam-1807 750 2 . . PUNCT bam-1807 750 3 metab metab PROPN bam-1807 750 4 . . PUNCT bam-1807 751 1 2009 2009 NUM bam-1807 751 2 ; ; PUNCT bam-1807 751 3 34:424 34:424 NUM bam-1807 751 4 - - SYM bam-1807 751 5 427 427 NUM bam-1807 751 6 . . PUNCT bam-1807 752 1 [ [ X bam-1807 752 2 124 124 NUM bam-1807 752 3 ] ] X bam-1807 752 4 zanchi zanchi PROPN bam-1807 752 5 ne ne PROPN bam-1807 752 6 , , PUNCT bam-1807 752 7 lancha lancha NOUN bam-1807 752 8 ah ah INTJ bam-1807 752 9 jr jr PROPN bam-1807 752 10 . . PUNCT bam-1807 752 11 mechanical mechanical ADJ bam-1807 752 12 stimuli stimulus NOUN bam-1807 752 13 of of ADP bam-1807 752 14 skeletal skeletal ADJ bam-1807 752 15 muscle muscle NOUN bam-1807 752 16 : : PUNCT bam-1807 752 17 implications implication NOUN bam-1807 752 18 on on ADP bam-1807 752 19 mtor mtor PROPN bam-1807 752 20 / / SYM bam-1807 752 21 p70s6k p70s6k PROPN bam-1807 752 22 and and CCONJ bam-1807 752 23 protein protein NOUN bam-1807 752 24 synthesis synthesis NOUN bam-1807 752 25 . . PUNCT bam-1807 753 1 eur eur PROPN bam-1807 753 2 j j PROPN bam-1807 753 3 appl appl PROPN bam-1807 753 4 physiol physiol PROPN bam-1807 753 5 . . PUNCT bam-1807 754 1 2008 2008 NUM bam-1807 754 2 ; ; PUNCT bam-1807 754 3 102:253 102:253 NUM bam-1807 754 4 - - SYM bam-1807 754 5 263 263 NUM bam-1807 754 6 . . PUNCT