id	sid	tid	token	lemma	pos
bam-4803	1	1	bam	bam	VERB
bam-4803	1	2	12	12	NUM
bam-4803	1	3	(	(	PUNCT
bam-4803	1	4	1	1	NUM
bam-4803	1	5	)	)	PUNCT
bam-4803	1	6	2002	2002	NUM
bam-4803	1	7	single	single	ADJ
bam-4803	1	8	-	-	PUNCT
bam-4803	1	9	particle	particle	NOUN
bam-4803	1	10	cryo	cryo	NOUN
bam-4803	1	11	-	-	PUNCT
bam-4803	1	12	em	em	PRON
bam-4803	1	13	of	of	ADP
bam-4803	1	14	the	the	DET
bam-4803	1	15	ryanodine	ryanodine	PROPN
bam-4803	1	16	receptor	receptor	NOUN
bam-4803	1	17	channel	channel	PROPN
bam-4803	1	18	eur	eur	PROPN
bam-4803	1	19	j	j	PROPN
bam-4803	1	20	transl	transl	PROPN
bam-4803	1	21	myol	myol	PROPN
bam-4803	1	22	basic	basic	ADJ
bam-4803	1	23	appl	appl	NOUN
bam-4803	1	24	myol	myol	NOUN
bam-4803	1	25	2015	2015	NUM
bam-4803	1	26	;	;	PUNCT
bam-4803	1	27	25	25	NUM
bam-4803	1	28	(	(	PUNCT
bam-4803	1	29	1	1	NUM
bam-4803	1	30	):	):	PUNCT
bam-4803	1	31	35	35	NUM
bam-4803	1	32	-	-	SYM
bam-4803	1	33	48	48	NUM
bam-4803	1	34	35	35	NUM
bam-4803	1	35	single	single	ADJ
bam-4803	1	36	-	-	PUNCT
bam-4803	1	37	particle	particle	NOUN
bam-4803	1	38	cryo	cryo	NOUN
bam-4803	1	39	-	-	PUNCT
bam-4803	1	40	em	em	PRON
bam-4803	1	41	of	of	ADP
bam-4803	1	42	the	the	DET
bam-4803	1	43	ryanodine	ryanodine	PROPN
bam-4803	1	44	receptor	receptor	NOUN
bam-4803	1	45	channel	channel	NOUN
bam-4803	1	46	in	in	ADP
bam-4803	1	47	an	an	DET
bam-4803	1	48	aqueous	aqueous	ADJ
bam-4803	1	49	environment	environment	NOUN
bam-4803	1	50	mariah	mariah	PROPN
bam-4803	1	51	r.	r.	PROPN
bam-4803	1	52	baker	baker	PROPN
bam-4803	1	53	,	,	PUNCT
bam-4803	1	54	guizhen	guizhen	PROPN
bam-4803	1	55	fan	fan	PROPN
bam-4803	1	56	and	and	CCONJ
bam-4803	1	57	irina	irina	PROPN
bam-4803	1	58	i.	i.	PROPN
bam-4803	1	59	serysheva	serysheva	PROPN
bam-4803	1	60	department	department	PROPN
bam-4803	1	61	of	of	ADP
bam-4803	1	62	biochemistry	biochemistry	NOUN
bam-4803	1	63	and	and	CCONJ
bam-4803	1	64	molecular	molecular	ADJ
bam-4803	1	65	biology	biology	NOUN
bam-4803	1	66	,	,	PUNCT
bam-4803	1	67	the	the	DET
bam-4803	1	68	university	university	PROPN
bam-4803	1	69	of	of	ADP
bam-4803	1	70	texas	texas	PROPN
bam-4803	1	71	medical	medical	PROPN
bam-4803	1	72	school	school	PROPN
bam-4803	1	73	at	at	ADP
bam-4803	1	74	houston	houston	PROPN
bam-4803	1	75	,	,	PUNCT
bam-4803	1	76	6431	6431	NUM
bam-4803	1	77	fannin	fannin	PROPN
bam-4803	1	78	street	street	PROPN
bam-4803	1	79	,	,	PUNCT
bam-4803	1	80	houston	houston	PROPN
bam-4803	1	81	,	,	PUNCT
bam-4803	1	82	tx	tx	PROPN
bam-4803	1	83	77030	77030	NUM
bam-4803	1	84	,	,	PUNCT
bam-4803	1	85	usa	usa	PROPN
bam-4803	1	86	abstract	abstract	ADJ
bam-4803	1	87	ryanodine	ryanodine	NOUN
bam-4803	1	88	receptors	receptor	NOUN
bam-4803	1	89	(	(	PUNCT
bam-4803	1	90	ryrs	ryr	NOUN
bam-4803	1	91	)	)	PUNCT
bam-4803	1	92	are	be	AUX
bam-4803	1	93	tetrameric	tetrameric	ADJ
bam-4803	1	94	ligand	ligand	NOUN
bam-4803	1	95	-	-	PUNCT
bam-4803	1	96	gated	gate	VERB
bam-4803	1	97	ca	ca	NOUN
bam-4803	1	98	2	2	NUM
bam-4803	1	99	+	+	NOUN
bam-4803	1	100	release	release	NOUN
bam-4803	1	101	channels	channel	NOUN
bam-4803	1	102	that	that	PRON
bam-4803	1	103	are	be	AUX
bam-4803	1	104	responsible	responsible	ADJ
bam-4803	1	105	for	for	ADP
bam-4803	1	106	the	the	DET
bam-4803	1	107	increase	increase	NOUN
bam-4803	1	108	of	of	ADP
bam-4803	1	109	cytosolic	cytosolic	NOUN
bam-4803	1	110	ca	ca	NOUN
bam-4803	1	111	2	2	NUM
bam-4803	1	112	+	+	NOUN
bam-4803	1	113	concentration	concentration	NOUN
bam-4803	1	114	leading	lead	VERB
bam-4803	1	115	to	to	ADP
bam-4803	1	116	muscle	muscle	NOUN
bam-4803	1	117	contraction	contraction	NOUN
bam-4803	1	118	.	.	PUNCT
bam-4803	2	1	our	our	PRON
bam-4803	2	2	current	current	ADJ
bam-4803	2	3	understanding	understanding	NOUN
bam-4803	2	4	of	of	ADP
bam-4803	2	5	ryr	ryr	NOUN
bam-4803	2	6	channel	channel	NOUN
bam-4803	2	7	gating	gating	NOUN
bam-4803	2	8	and	and	CCONJ
bam-4803	2	9	regulation	regulation	NOUN
bam-4803	2	10	is	be	AUX
bam-4803	2	11	greatly	greatly	ADV
bam-4803	2	12	limited	limit	VERB
bam-4803	2	13	due	due	ADP
bam-4803	2	14	to	to	ADP
bam-4803	2	15	the	the	DET
bam-4803	2	16	lack	lack	NOUN
bam-4803	2	17	of	of	ADP
bam-4803	2	18	a	a	DET
bam-4803	2	19	high	high	ADJ
bam-4803	2	20	-	-	PUNCT
bam-4803	2	21	resolution	resolution	NOUN
bam-4803	2	22	structure	structure	NOUN
bam-4803	2	23	of	of	ADP
bam-4803	2	24	the	the	DET
bam-4803	2	25	channel	channel	NOUN
bam-4803	2	26	protein	protein	NOUN
bam-4803	2	27	.	.	PUNCT
bam-4803	3	1	the	the	DET
bam-4803	3	2	enormous	enormous	ADJ
bam-4803	3	3	size	size	NOUN
bam-4803	3	4	and	and	CCONJ
bam-4803	3	5	unwieldy	unwieldy	ADJ
bam-4803	3	6	shape	shape	NOUN
bam-4803	3	7	of	of	ADP
bam-4803	3	8	ca	ca	NOUN
bam-4803	3	9	2	2	NUM
bam-4803	3	10	+	+	NOUN
bam-4803	3	11	release	release	NOUN
bam-4803	3	12	channels	channel	NOUN
bam-4803	3	13	make	make	VERB
bam-4803	3	14	x	x	NOUN
bam-4803	3	15	-	-	NOUN
bam-4803	3	16	ray	ray	NOUN
bam-4803	3	17	or	or	CCONJ
bam-4803	3	18	nmr	nmr	NOUN
bam-4803	3	19	methods	method	NOUN
bam-4803	3	20	difficult	difficult	ADJ
bam-4803	3	21	to	to	PART
bam-4803	3	22	apply	apply	VERB
bam-4803	3	23	for	for	ADP
bam-4803	3	24	high	high	ADJ
bam-4803	3	25	-	-	PUNCT
bam-4803	3	26	resolution	resolution	NOUN
bam-4803	3	27	structural	structural	ADJ
bam-4803	3	28	analysis	analysis	NOUN
bam-4803	3	29	of	of	ADP
bam-4803	3	30	the	the	DET
bam-4803	3	31	full	full	ADJ
bam-4803	3	32	-	-	PUNCT
bam-4803	3	33	length	length	NOUN
bam-4803	3	34	functional	functional	ADJ
bam-4803	3	35	channel	channel	NOUN
bam-4803	3	36	.	.	PUNCT
bam-4803	4	1	single	single	ADJ
bam-4803	4	2	-	-	PUNCT
bam-4803	4	3	particle	particle	NOUN
bam-4803	4	4	electron	electron	NOUN
bam-4803	4	5	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	4	6	(	(	PUNCT
bam-4803	4	7	cryo	cryo	NOUN
bam-4803	4	8	-	-	PUNCT
bam-4803	4	9	em	em	PROPN
bam-4803	4	10	)	)	PUNCT
bam-4803	4	11	is	be	AUX
bam-4803	4	12	one	one	NUM
bam-4803	4	13	of	of	ADP
bam-4803	4	14	the	the	DET
bam-4803	4	15	only	only	ADJ
bam-4803	4	16	effective	effective	ADJ
bam-4803	4	17	techniques	technique	NOUN
bam-4803	4	18	for	for	ADP
bam-4803	4	19	the	the	DET
bam-4803	4	20	study	study	NOUN
bam-4803	4	21	of	of	ADP
bam-4803	4	22	such	such	DET
bam-4803	4	23	a	a	DET
bam-4803	4	24	large	large	ADJ
bam-4803	4	25	integral	integral	ADJ
bam-4803	4	26	membrane	membrane	NOUN
bam-4803	4	27	protein	protein	NOUN
bam-4803	4	28	and	and	CCONJ
bam-4803	4	29	its	its	PRON
bam-4803	4	30	molecular	molecular	ADJ
bam-4803	4	31	interactions	interaction	NOUN
bam-4803	4	32	.	.	PUNCT
bam-4803	5	1	despite	despite	SCONJ
bam-4803	5	2	recent	recent	ADJ
bam-4803	5	3	developments	development	NOUN
bam-4803	5	4	in	in	ADP
bam-4803	5	5	cryoem	cryoem	NOUN
bam-4803	5	6	technologies	technology	NOUN
bam-4803	5	7	and	and	CCONJ
bam-4803	5	8	break	break	NOUN
bam-4803	5	9	-	-	PUNCT
bam-4803	5	10	through	through	ADP
bam-4803	5	11	single	single	ADJ
bam-4803	5	12	-	-	PUNCT
bam-4803	5	13	particle	particle	NOUN
bam-4803	5	14	cryo	cryo	NOUN
bam-4803	5	15	-	-	PUNCT
bam-4803	5	16	em	em	PRON
bam-4803	5	17	studies	study	NOUN
bam-4803	5	18	of	of	ADP
bam-4803	5	19	ion	ion	NOUN
bam-4803	5	20	channels	channel	NOUN
bam-4803	5	21	,	,	PUNCT
bam-4803	5	22	cryospecimen	cryospeciman	NOUN
bam-4803	5	23	preparation	preparation	NOUN
bam-4803	5	24	,	,	PUNCT
bam-4803	5	25	particularly	particularly	ADV
bam-4803	5	26	the	the	DET
bam-4803	5	27	presence	presence	NOUN
bam-4803	5	28	of	of	ADP
bam-4803	5	29	detergent	detergent	NOUN
bam-4803	5	30	in	in	ADP
bam-4803	5	31	the	the	DET
bam-4803	5	32	buffer	buffer	NOUN
bam-4803	5	33	,	,	PUNCT
bam-4803	5	34	remains	remain	VERB
bam-4803	5	35	the	the	DET
bam-4803	5	36	main	main	ADJ
bam-4803	5	37	impediment	impediment	NOUN
bam-4803	5	38	to	to	ADP
bam-4803	5	39	obtaining	obtain	VERB
bam-4803	5	40	atomic	atomic	ADJ
bam-4803	5	41	-	-	PUNCT
bam-4803	5	42	resolution	resolution	NOUN
bam-4803	5	43	structures	structure	NOUN
bam-4803	5	44	of	of	ADP
bam-4803	5	45	ion	ion	NOUN
bam-4803	5	46	channels	channel	NOUN
bam-4803	5	47	and	and	CCONJ
bam-4803	5	48	a	a	DET
bam-4803	5	49	multitude	multitude	NOUN
bam-4803	5	50	of	of	ADP
bam-4803	5	51	other	other	ADJ
bam-4803	5	52	integral	integral	ADJ
bam-4803	5	53	membrane	membrane	NOUN
bam-4803	5	54	protein	protein	NOUN
bam-4803	5	55	complexes	complex	NOUN
bam-4803	5	56	.	.	PUNCT
bam-4803	6	1	in	in	ADP
bam-4803	6	2	this	this	DET
bam-4803	6	3	review	review	NOUN
bam-4803	6	4	we	we	PRON
bam-4803	6	5	will	will	AUX
bam-4803	6	6	discuss	discuss	VERB
bam-4803	6	7	properties	property	NOUN
bam-4803	6	8	of	of	ADP
bam-4803	6	9	several	several	ADJ
bam-4803	6	10	detergents	detergent	NOUN
bam-4803	6	11	that	that	PRON
bam-4803	6	12	have	have	AUX
bam-4803	6	13	been	be	AUX
bam-4803	6	14	successfully	successfully	ADV
bam-4803	6	15	utilized	utilize	VERB
bam-4803	6	16	in	in	ADP
bam-4803	6	17	cryo	cryo	NOUN
bam-4803	6	18	-	-	PUNCT
bam-4803	6	19	em	em	PRON
bam-4803	6	20	studies	study	NOUN
bam-4803	6	21	of	of	ADP
bam-4803	6	22	ion	ion	NOUN
bam-4803	6	23	channels	channel	NOUN
bam-4803	6	24	and	and	CCONJ
bam-4803	6	25	the	the	DET
bam-4803	6	26	emergence	emergence	NOUN
bam-4803	6	27	of	of	ADP
bam-4803	6	28	the	the	DET
bam-4803	6	29	detergent	detergent	ADJ
bam-4803	6	30	alternative	alternative	ADJ
bam-4803	6	31	amphipol	amphipol	NOUN
bam-4803	6	32	to	to	PART
bam-4803	6	33	stabilize	stabilize	VERB
bam-4803	6	34	ion	ion	NOUN
bam-4803	6	35	channels	channel	NOUN
bam-4803	6	36	for	for	ADP
bam-4803	6	37	structurefunction	structurefunction	NOUN
bam-4803	6	38	characterization	characterization	NOUN
bam-4803	6	39	.	.	PUNCT
bam-4803	7	1	future	future	ADJ
bam-4803	7	2	structural	structural	ADJ
bam-4803	7	3	studies	study	NOUN
bam-4803	7	4	of	of	ADP
bam-4803	7	5	challenging	challenge	VERB
bam-4803	7	6	specimen	speciman	NOUN
bam-4803	7	7	like	like	ADP
bam-4803	7	8	ion	ion	NOUN
bam-4803	7	9	channels	channel	NOUN
bam-4803	7	10	are	be	AUX
bam-4803	7	11	likely	likely	ADJ
bam-4803	7	12	to	to	PART
bam-4803	7	13	be	be	AUX
bam-4803	7	14	facilitated	facilitate	VERB
bam-4803	7	15	by	by	ADP
bam-4803	7	16	cryo	cryo	PROPN
bam-4803	7	17	-	-	PUNCT
bam-4803	7	18	em	em	PRON
bam-4803	7	19	amenable	amenable	ADJ
bam-4803	7	20	detergents	detergent	NOUN
bam-4803	7	21	or	or	CCONJ
bam-4803	7	22	alternative	alternative	ADJ
bam-4803	7	23	surfactants	surfactant	NOUN
bam-4803	7	24	.	.	PUNCT
bam-4803	8	1	key	key	ADJ
bam-4803	8	2	words	word	NOUN
bam-4803	8	3	:	:	PUNCT
bam-4803	8	4	ryanodine	ryanodine	NOUN
bam-4803	8	5	receptor	receptor	NOUN
bam-4803	8	6	,	,	PUNCT
bam-4803	8	7	membrane	membrane	NOUN
bam-4803	8	8	proteins	protein	NOUN
bam-4803	8	9	,	,	PUNCT
bam-4803	8	10	electron	electron	NOUN
bam-4803	8	11	cryo	cryo	NOUN
bam-4803	8	12	-	-	PUNCT
bam-4803	8	13	microscopy	microscopy	NOUN
bam-4803	8	14	,	,	PUNCT
bam-4803	8	15	cryospecimen	cryospeciman	NOUN
bam-4803	8	16	preparation	preparation	NOUN
bam-4803	8	17	,	,	PUNCT
bam-4803	8	18	detergents	detergent	NOUN
bam-4803	8	19	,	,	PUNCT
bam-4803	8	20	amphipol	amphipol	VERB
bam-4803	8	21	eur	eur	PROPN
bam-4803	8	22	j	j	PROPN
bam-4803	8	23	transl	transl	PROPN
bam-4803	9	1	myol	myol	PROPN
bam-4803	9	2	basic	basic	ADJ
bam-4803	9	3	appl	appl	NOUN
bam-4803	9	4	myol	myol	NOUN
bam-4803	9	5	2015	2015	NUM
bam-4803	9	6	;	;	PUNCT
bam-4803	9	7	25	25	NUM
bam-4803	9	8	(	(	PUNCT
bam-4803	9	9	1	1	NUM
bam-4803	9	10	):	):	PUNCT
bam-4803	9	11	35	35	NUM
bam-4803	9	12	-	-	SYM
bam-4803	9	13	48	48	NUM
bam-4803	9	14	membrane	membrane	NOUN
bam-4803	9	15	proteins	protein	NOUN
bam-4803	9	16	have	have	AUX
bam-4803	9	17	always	always	ADV
bam-4803	9	18	been	be	AUX
bam-4803	9	19	attractive	attractive	ADJ
bam-4803	9	20	,	,	PUNCT
bam-4803	9	21	yet	yet	CCONJ
bam-4803	9	22	challenging	challenging	ADJ
bam-4803	9	23	subjects	subject	NOUN
bam-4803	9	24	in	in	ADP
bam-4803	9	25	structural	structural	ADJ
bam-4803	9	26	biology	biology	NOUN
bam-4803	9	27	.	.	PUNCT
bam-4803	10	1	membrane	membrane	NOUN
bam-4803	10	2	proteins	protein	NOUN
bam-4803	10	3	contain	contain	VERB
bam-4803	10	4	specialized	specialized	ADJ
bam-4803	10	5	domains	domain	NOUN
bam-4803	10	6	that	that	PRON
bam-4803	10	7	are	be	AUX
bam-4803	10	8	specifically	specifically	ADV
bam-4803	10	9	adapted	adapt	VERB
bam-4803	10	10	to	to	PART
bam-4803	10	11	reside	reside	VERB
bam-4803	10	12	within	within	ADP
bam-4803	10	13	the	the	DET
bam-4803	10	14	hydrophobic	hydrophobic	NOUN
bam-4803	10	15	environment	environment	NOUN
bam-4803	10	16	of	of	ADP
bam-4803	10	17	the	the	DET
bam-4803	10	18	lipid	lipid	NOUN
bam-4803	10	19	bilayer	bilayer	NOUN
bam-4803	10	20	allowing	allow	VERB
bam-4803	10	21	for	for	SCONJ
bam-4803	10	22	the	the	DET
bam-4803	10	23	protein	protein	NOUN
bam-4803	10	24	to	to	PART
bam-4803	10	25	communicate	communicate	VERB
bam-4803	10	26	cell	cell	NOUN
bam-4803	10	27	signals	signal	NOUN
bam-4803	10	28	across	across	ADP
bam-4803	10	29	the	the	DET
bam-4803	10	30	biological	biological	ADJ
bam-4803	10	31	membrane	membrane	NOUN
bam-4803	10	32	.	.	PUNCT
bam-4803	11	1	ion	ion	NOUN
bam-4803	11	2	channels	channel	NOUN
bam-4803	11	3	are	be	AUX
bam-4803	11	4	integral	integral	ADJ
bam-4803	11	5	membrane	membrane	NOUN
bam-4803	11	6	proteins	protein	NOUN
bam-4803	11	7	that	that	PRON
bam-4803	11	8	are	be	AUX
bam-4803	11	9	responsible	responsible	ADJ
bam-4803	11	10	for	for	ADP
bam-4803	11	11	movements	movement	NOUN
bam-4803	11	12	of	of	ADP
bam-4803	11	13	ions	ion	NOUN
bam-4803	11	14	across	across	ADP
bam-4803	11	15	the	the	DET
bam-4803	11	16	cell	cell	NOUN
bam-4803	11	17	membrane	membrane	NOUN
bam-4803	11	18	and	and	CCONJ
bam-4803	11	19	for	for	ADP
bam-4803	11	20	maintaining	maintain	VERB
bam-4803	11	21	the	the	DET
bam-4803	11	22	ion	ion	NOUN
bam-4803	11	23	concentration	concentration	NOUN
bam-4803	11	24	gradients	gradient	NOUN
bam-4803	11	25	within	within	ADP
bam-4803	11	26	cells	cell	NOUN
bam-4803	11	27	,	,	PUNCT
bam-4803	11	28	driving	drive	VERB
bam-4803	11	29	numerous	numerous	ADJ
bam-4803	11	30	physiological	physiological	ADJ
bam-4803	11	31	processes	process	NOUN
bam-4803	11	32	such	such	ADJ
bam-4803	11	33	as	as	ADP
bam-4803	11	34	muscle	muscle	NOUN
bam-4803	11	35	contraction	contraction	NOUN
bam-4803	11	36	,	,	PUNCT
bam-4803	11	37	fertilization	fertilization	NOUN
bam-4803	11	38	,	,	PUNCT
bam-4803	11	39	learning	learning	NOUN
bam-4803	11	40	and	and	CCONJ
bam-4803	11	41	memory	memory	NOUN
bam-4803	11	42	.	.	PUNCT
bam-4803	12	1	given	give	VERB
bam-4803	12	2	the	the	DET
bam-4803	12	3	significant	significant	ADJ
bam-4803	12	4	role	role	NOUN
bam-4803	12	5	of	of	ADP
bam-4803	12	6	ion	ion	NOUN
bam-4803	12	7	channels	channel	NOUN
bam-4803	12	8	in	in	ADP
bam-4803	12	9	myriad	myriad	ADJ
bam-4803	12	10	cell	cell	NOUN
bam-4803	12	11	functions	function	NOUN
bam-4803	12	12	,	,	PUNCT
bam-4803	12	13	knowledge	knowledge	NOUN
bam-4803	12	14	of	of	ADP
bam-4803	12	15	their	their	PRON
bam-4803	12	16	high	high	ADJ
bam-4803	12	17	-	-	PUNCT
bam-4803	12	18	resolution	resolution	NOUN
bam-4803	12	19	3d	3d	NUM
bam-4803	12	20	structures	structure	NOUN
bam-4803	12	21	is	be	AUX
bam-4803	12	22	a	a	DET
bam-4803	12	23	critical	critical	ADJ
bam-4803	12	24	prerequisite	prerequisite	NOUN
bam-4803	12	25	to	to	ADP
bam-4803	12	26	our	our	PRON
bam-4803	12	27	understanding	understanding	NOUN
bam-4803	12	28	of	of	ADP
bam-4803	12	29	channel	channel	NOUN
bam-4803	12	30	functions	function	NOUN
bam-4803	12	31	and	and	CCONJ
bam-4803	12	32	molecular	molecular	ADJ
bam-4803	12	33	mechanisms	mechanism	NOUN
bam-4803	12	34	underlying	underlie	VERB
bam-4803	12	35	membrane	membrane	NOUN
bam-4803	12	36	transport	transport	NOUN
bam-4803	12	37	in	in	ADP
bam-4803	12	38	both	both	CCONJ
bam-4803	12	39	normal	normal	ADJ
bam-4803	12	40	and	and	CCONJ
bam-4803	12	41	disease	disease	NOUN
bam-4803	12	42	states	state	NOUN
bam-4803	12	43	.	.	PUNCT
bam-4803	13	1	while	while	SCONJ
bam-4803	13	2	membrane	membrane	ADJ
bam-4803	13	3	proteins	protein	NOUN
bam-4803	13	4	are	be	AUX
bam-4803	13	5	abundant	abundant	ADJ
bam-4803	13	6	,	,	PUNCT
bam-4803	13	7	representing	represent	VERB
bam-4803	13	8	20	20	NUM
bam-4803	13	9	-	-	SYM
bam-4803	13	10	30	30	NUM
bam-4803	13	11	%	%	NOUN
bam-4803	13	12	of	of	ADP
bam-4803	13	13	the	the	DET
bam-4803	13	14	proteome	proteome	NOUN
bam-4803	13	15	,	,	PUNCT
bam-4803	13	16	high	high	ADJ
bam-4803	13	17	-	-	PUNCT
bam-4803	13	18	resolution	resolution	NOUN
bam-4803	13	19	structures	structure	NOUN
bam-4803	13	20	solved	solve	VERB
bam-4803	13	21	for	for	ADP
bam-4803	13	22	them	they	PRON
bam-4803	13	23	are	be	AUX
bam-4803	13	24	disproportionally	disproportionally	ADV
bam-4803	13	25	less	less	ADJ
bam-4803	13	26	,	,	PUNCT
bam-4803	13	27	~2	~2	ADJ
bam-4803	13	28	%	%	NOUN
bam-4803	13	29	of	of	ADP
bam-4803	13	30	unique	unique	ADJ
bam-4803	13	31	proteins	protein	NOUN
bam-4803	13	32	in	in	ADP
bam-4803	13	33	the	the	DET
bam-4803	13	34	pdb	pdb	NOUN
bam-4803	13	35	to	to	ADP
bam-4803	13	36	date	date	NOUN
bam-4803	13	37	,	,	PUNCT
bam-4803	13	38	proving	prove	VERB
bam-4803	13	39	them	they	PRON
bam-4803	13	40	to	to	PART
bam-4803	13	41	be	be	AUX
bam-4803	13	42	more	more	ADV
bam-4803	13	43	difficult	difficult	ADJ
bam-4803	13	44	targets	target	NOUN
bam-4803	13	45	than	than	ADP
bam-4803	13	46	soluble	soluble	ADJ
bam-4803	13	47	proteins	protein	NOUN
bam-4803	13	48	.	.	PUNCT
bam-4803	14	1	1	1	NUM
bam-4803	14	2	hindering	hinder	VERB
bam-4803	14	3	efforts	effort	NOUN
bam-4803	14	4	to	to	PART
bam-4803	14	5	uncover	uncover	VERB
bam-4803	14	6	the	the	DET
bam-4803	14	7	structures	structure	NOUN
bam-4803	14	8	of	of	ADP
bam-4803	14	9	ion	ion	NOUN
bam-4803	14	10	channels	channel	NOUN
bam-4803	14	11	is	be	AUX
bam-4803	14	12	their	their	PRON
bam-4803	14	13	association	association	NOUN
bam-4803	14	14	with	with	ADP
bam-4803	14	15	the	the	DET
bam-4803	14	16	lipid	lipid	NOUN
bam-4803	14	17	bilayer	bilayer	NOUN
bam-4803	14	18	,	,	PUNCT
bam-4803	14	19	the	the	DET
bam-4803	14	20	need	need	NOUN
bam-4803	14	21	to	to	PART
bam-4803	14	22	extract	extract	VERB
bam-4803	14	23	them	they	PRON
bam-4803	14	24	from	from	ADP
bam-4803	14	25	the	the	DET
bam-4803	14	26	membrane	membrane	NOUN
bam-4803	14	27	,	,	PUNCT
bam-4803	14	28	their	their	PRON
bam-4803	14	29	unwieldy	unwieldy	ADJ
bam-4803	14	30	size	size	NOUN
bam-4803	14	31	and	and	CCONJ
bam-4803	14	32	often	often	ADV
bam-4803	14	33	dynamic	dynamic	ADJ
bam-4803	14	34	nature	nature	NOUN
bam-4803	14	35	.	.	PUNCT
bam-4803	15	1	large	large	ADJ
bam-4803	15	2	protein	protein	NOUN
bam-4803	15	3	size	size	NOUN
bam-4803	15	4	,	,	PUNCT
bam-4803	15	5	flexibility	flexibility	NOUN
bam-4803	15	6	and	and	CCONJ
bam-4803	15	7	membrane	membrane	NOUN
bam-4803	15	8	-	-	PUNCT
bam-4803	15	9	associated	associate	VERB
bam-4803	15	10	domains	domain	NOUN
bam-4803	15	11	make	make	VERB
bam-4803	15	12	x	x	ADJ
bam-4803	15	13	-	-	NOUN
bam-4803	15	14	ray	ray	NOUN
bam-4803	15	15	crystallography	crystallography	NOUN
bam-4803	15	16	or	or	CCONJ
bam-4803	15	17	nmr	nmr	NOUN
bam-4803	15	18	methods	method	NOUN
bam-4803	15	19	difficult	difficult	ADJ
bam-4803	15	20	to	to	PART
bam-4803	15	21	apply	apply	VERB
bam-4803	15	22	for	for	ADP
bam-4803	15	23	structure	structure	NOUN
bam-4803	15	24	determination	determination	NOUN
bam-4803	15	25	of	of	ADP
bam-4803	15	26	full	full	ADJ
bam-4803	15	27	-	-	PUNCT
bam-4803	15	28	length	length	NOUN
bam-4803	15	29	membrane	membrane	NOUN
bam-4803	15	30	proteins	protein	NOUN
bam-4803	15	31	.	.	PUNCT
bam-4803	16	1	to	to	ADP
bam-4803	16	2	date	date	NOUN
bam-4803	16	3	,	,	PUNCT
bam-4803	16	4	single	single	ADJ
bam-4803	16	5	-	-	PUNCT
bam-4803	16	6	particle	particle	NOUN
bam-4803	16	7	electron	electron	NOUN
bam-4803	16	8	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	16	9	(	(	PUNCT
bam-4803	16	10	cryo	cryo	NOUN
bam-4803	16	11	-	-	PUNCT
bam-4803	16	12	em	em	PROPN
bam-4803	16	13	)	)	PUNCT
bam-4803	16	14	has	have	AUX
bam-4803	16	15	emerged	emerge	VERB
bam-4803	16	16	as	as	ADP
bam-4803	16	17	an	an	DET
bam-4803	16	18	effective	effective	ADJ
bam-4803	16	19	and	and	CCONJ
bam-4803	16	20	straightforward	straightforward	ADJ
bam-4803	16	21	approach	approach	NOUN
bam-4803	16	22	for	for	ADP
bam-4803	16	23	the	the	DET
bam-4803	16	24	study	study	NOUN
bam-4803	16	25	of	of	ADP
bam-4803	16	26	membrane	membrane	NOUN
bam-4803	16	27	protein	protein	NOUN
bam-4803	16	28	complexes	complex	NOUN
bam-4803	16	29	,	,	PUNCT
bam-4803	16	30	their	their	PRON
bam-4803	16	31	interactions	interaction	NOUN
bam-4803	16	32	and	and	CCONJ
bam-4803	16	33	dynamics	dynamic	NOUN
bam-4803	16	34	in	in	ADP
bam-4803	16	35	different	different	ADJ
bam-4803	16	36	functional	functional	ADJ
bam-4803	16	37	states	state	NOUN
bam-4803	16	38	in	in	ADP
bam-4803	16	39	a	a	DET
bam-4803	16	40	vitrified	vitrify	VERB
bam-4803	16	41	aqueous	aqueous	ADJ
bam-4803	16	42	solution	solution	NOUN
bam-4803	16	43	or	or	CCONJ
bam-4803	16	44	lipid	lipid	NOUN
bam-4803	16	45	environment	environment	NOUN
bam-4803	16	46	.	.	PUNCT
bam-4803	17	1	2	2	NUM
bam-4803	17	2	-	-	SYM
bam-4803	17	3	5	5	NUM
bam-4803	17	4	recent	recent	ADJ
bam-4803	17	5	advances	advance	NOUN
bam-4803	17	6	in	in	ADP
bam-4803	17	7	cryo	cryo	NOUN
bam-4803	17	8	-	-	PUNCT
bam-4803	17	9	em	em	PRON
bam-4803	17	10	technology	technology	NOUN
bam-4803	17	11	in	in	ADP
bam-4803	17	12	combination	combination	NOUN
bam-4803	17	13	with	with	ADP
bam-4803	17	14	continuing	continue	VERB
bam-4803	17	15	developments	development	NOUN
bam-4803	17	16	in	in	ADP
bam-4803	17	17	image	image	NOUN
bam-4803	17	18	processing	processing	NOUN
bam-4803	17	19	software	software	NOUN
bam-4803	17	20	have	have	AUX
bam-4803	17	21	made	make	VERB
bam-4803	17	22	it	it	PRON
bam-4803	17	23	possible	possible	ADJ
bam-4803	17	24	to	to	PART
bam-4803	17	25	obtain	obtain	VERB
bam-4803	17	26	structures	structure	NOUN
bam-4803	17	27	of	of	ADP
bam-4803	17	28	protein	protein	NOUN
bam-4803	17	29	complexes	complex	NOUN
bam-4803	17	30	beyond	beyond	ADP
bam-4803	17	31	5	5	NUM
bam-4803	17	32	å	å	PROPN
bam-4803	17	33	resolution	resolution	NOUN
bam-4803	17	34	,	,	PUNCT
bam-4803	17	35	with	with	ADP
bam-4803	17	36	some	some	PRON
bam-4803	17	37	achieving	achieve	VERB
bam-4803	17	38	near	near	ADP
bam-4803	17	39	-	-	PUNCT
bam-4803	17	40	atomic	atomic	ADJ
bam-4803	17	41	resolutions	resolution	NOUN
bam-4803	17	42	of	of	ADP
bam-4803	17	43	3	3	NUM
bam-4803	17	44	-	-	SYM
bam-4803	17	45	4	4	NUM
bam-4803	17	46	å	å	NOUN
bam-4803	17	47	,	,	PUNCT
bam-4803	17	48	single	single	ADJ
bam-4803	17	49	-	-	PUNCT
bam-4803	17	50	particle	particle	NOUN
bam-4803	17	51	cryo	cryo	NOUN
bam-4803	17	52	-	-	PUNCT
bam-4803	17	53	em	em	PRON
bam-4803	17	54	of	of	ADP
bam-4803	17	55	the	the	DET
bam-4803	17	56	ryanodine	ryanodine	PROPN
bam-4803	17	57	receptor	receptor	NOUN
bam-4803	17	58	channel	channel	PROPN
bam-4803	17	59	eur	eur	PROPN
bam-4803	17	60	j	j	PROPN
bam-4803	17	61	transl	transl	PROPN
bam-4803	17	62	myol	myol	PROPN
bam-4803	17	63	basic	basic	ADJ
bam-4803	17	64	appl	appl	NOUN
bam-4803	17	65	myol	myol	NOUN
bam-4803	17	66	2015	2015	NUM
bam-4803	17	67	;	;	PUNCT
bam-4803	17	68	25	25	NUM
bam-4803	17	69	(	(	PUNCT
bam-4803	17	70	1	1	NUM
bam-4803	17	71	):	):	PUNCT
bam-4803	17	72	35	35	NUM
bam-4803	17	73	-	-	SYM
bam-4803	17	74	48	48	NUM
bam-4803	17	75	36	36	NUM
bam-4803	17	76	allowing	allow	VERB
bam-4803	17	77	for	for	ADP
bam-4803	17	78	high	high	ADJ
bam-4803	17	79	-	-	PUNCT
bam-4803	17	80	resolution	resolution	NOUN
bam-4803	17	81	structural	structural	ADJ
bam-4803	17	82	models	model	NOUN
bam-4803	17	83	to	to	PART
bam-4803	17	84	be	be	AUX
bam-4803	17	85	derived	derive	VERB
bam-4803	17	86	de	de	X
bam-4803	17	87	novo	novo	NOUN
bam-4803	17	88	from	from	ADP
bam-4803	17	89	cryo	cryo	NOUN
bam-4803	17	90	-	-	PUNCT
bam-4803	17	91	em	em	PROPN
bam-4803	17	92	density	density	NOUN
bam-4803	17	93	maps	map	NOUN
bam-4803	17	94	.	.	PUNCT
bam-4803	18	1	6	6	NUM
bam-4803	18	2	-	-	SYM
bam-4803	18	3	14	14	NUM
bam-4803	18	4	applications	application	NOUN
bam-4803	18	5	of	of	ADP
bam-4803	18	6	these	these	DET
bam-4803	18	7	enhanced	enhance	VERB
bam-4803	18	8	technologies	technology	NOUN
bam-4803	18	9	by	by	ADP
bam-4803	18	10	singleparticle	singleparticle	PROPN
bam-4803	18	11	cryo	cryo	PROPN
bam-4803	18	12	-	-	PUNCT
bam-4803	18	13	em	em	PRON
bam-4803	18	14	include	include	VERB
bam-4803	18	15	protein	protein	NOUN
bam-4803	18	16	assemblies	assembly	NOUN
bam-4803	18	17	within	within	ADP
bam-4803	18	18	a	a	DET
bam-4803	18	19	wide	wide	ADJ
bam-4803	18	20	range	range	NOUN
bam-4803	18	21	of	of	ADP
bam-4803	18	22	molecular	molecular	ADJ
bam-4803	18	23	weights	weight	NOUN
bam-4803	18	24	(	(	PUNCT
bam-4803	18	25	~170	~170	NOUN
bam-4803	18	26	kda	kda	NOUN
bam-4803	18	27	–	–	PUNCT
bam-4803	18	28	~4	~4	NOUN
bam-4803	18	29	mda	mda	PROPN
bam-4803	18	30	)	)	PUNCT
bam-4803	18	31	and	and	CCONJ
bam-4803	18	32	complex	complex	ADJ
bam-4803	18	33	symmetry	symmetry	NOUN
bam-4803	18	34	.	.	PUNCT
bam-4803	19	1	14	14	NUM
bam-4803	19	2	-	-	SYM
bam-4803	19	3	16	16	NUM
bam-4803	19	4	among	among	ADP
bam-4803	19	5	recently	recently	ADV
bam-4803	19	6	reported	report	VERB
bam-4803	19	7	near	near	ADJ
bam-4803	19	8	-	-	PUNCT
bam-4803	19	9	atomic	atomic	ADJ
bam-4803	19	10	resolution	resolution	NOUN
bam-4803	19	11	structures	structure	NOUN
bam-4803	19	12	are	be	AUX
bam-4803	19	13	a	a	DET
bam-4803	19	14	3.4	3.4	NUM
bam-4803	19	15	åresolution	åresolution	NOUN
bam-4803	19	16	structure	structure	NOUN
bam-4803	19	17	of	of	ADP
bam-4803	19	18	the	the	DET
bam-4803	19	19	tetrameric	tetrameric	ADJ
bam-4803	19	20	trpv1	trpv1	NOUN
bam-4803	19	21	ion	ion	NOUN
bam-4803	19	22	channel	channel	NOUN
bam-4803	19	23	and	and	CCONJ
bam-4803	19	24	a	a	DET
bam-4803	19	25	4.5	4.5	NUM
bam-4803	19	26	å	å	NOUN
bam-4803	19	27	-	-	NOUN
bam-4803	19	28	structure	structure	NOUN
bam-4803	19	29	of	of	ADP
bam-4803	19	30	the	the	DET
bam-4803	19	31	-secretase	-secretase	NUM
bam-4803	19	32	,	,	PUNCT
bam-4803	19	33	a	a	DET
bam-4803	19	34	~170	~170	NOUN
bam-4803	19	35	kda	kda	NOUN
bam-4803	19	36	`	`	PUNCT
bam-4803	19	37	membrane	membrane	NOUN
bam-4803	19	38	-	-	PUNCT
bam-4803	19	39	embedded	embed	VERB
bam-4803	19	40	protease	protease	NOUN
bam-4803	19	41	,	,	PUNCT
bam-4803	19	42	determined	determine	VERB
bam-4803	19	43	by	by	ADP
bam-4803	19	44	single	single	ADJ
bam-4803	19	45	-	-	PUNCT
bam-4803	19	46	particle	particle	NOUN
bam-4803	19	47	cryo	cryo	NOUN
bam-4803	19	48	-	-	PUNCT
bam-4803	19	49	em	em	PROPN
bam-4803	19	50	.	.	PROPN
bam-4803	19	51	13,14	13,14	NUM
bam-4803	19	52	the	the	DET
bam-4803	19	53	ryanodine	ryanodine	PROPN
bam-4803	19	54	receptor	receptor	NOUN
bam-4803	19	55	(	(	PUNCT
bam-4803	19	56	ryr	ryr	NOUN
bam-4803	19	57	)	)	PUNCT
bam-4803	19	58	,	,	PUNCT
bam-4803	19	59	a	a	DET
bam-4803	19	60	homo	homo	NOUN
bam-4803	19	61	-	-	PUNCT
bam-4803	19	62	tetrameric	tetrameric	ADJ
bam-4803	19	63	ca	ca	NOUN
bam-4803	19	64	2	2	NUM
bam-4803	19	65	+	+	NOUN
bam-4803	19	66	release	release	NOUN
bam-4803	19	67	channel	channel	NOUN
bam-4803	19	68	,	,	PUNCT
bam-4803	19	69	was	be	AUX
bam-4803	19	70	one	one	NUM
bam-4803	19	71	of	of	ADP
bam-4803	19	72	the	the	DET
bam-4803	19	73	first	first	ADJ
bam-4803	19	74	non	non	ADJ
bam-4803	19	75	-	-	ADJ
bam-4803	19	76	icosahedral	icosahedral	ADJ
bam-4803	19	77	proteins	protein	NOUN
bam-4803	19	78	to	to	PART
bam-4803	19	79	be	be	AUX
bam-4803	19	80	solved	solve	VERB
bam-4803	19	81	by	by	ADP
bam-4803	19	82	single	single	ADJ
bam-4803	19	83	-	-	PUNCT
bam-4803	19	84	particle	particle	NOUN
bam-4803	19	85	cryo	cryo	NOUN
bam-4803	19	86	-	-	PUNCT
bam-4803	19	87	em	em	PROPN
bam-4803	19	88	,	,	PUNCT
bam-4803	19	89	in	in	ADP
bam-4803	19	90	part	part	NOUN
bam-4803	19	91	owing	owe	VERB
bam-4803	19	92	to	to	ADP
bam-4803	19	93	its	its	PRON
bam-4803	19	94	massive	massive	ADJ
bam-4803	19	95	size	size	NOUN
bam-4803	19	96	of	of	ADP
bam-4803	19	97	2.3	2.3	NUM
bam-4803	19	98	mda	mda	NOUN
bam-4803	19	99	.	.	PUNCT
bam-4803	20	1	however	however	ADV
bam-4803	20	2	,	,	PUNCT
bam-4803	20	3	despite	despite	SCONJ
bam-4803	20	4	rigorous	rigorous	ADJ
bam-4803	20	5	efforts	effort	NOUN
bam-4803	20	6	spent	spend	VERB
bam-4803	20	7	to	to	PART
bam-4803	20	8	investigate	investigate	VERB
bam-4803	20	9	structurefunctional	structurefunctional	ADJ
bam-4803	20	10	characteristics	characteristic	NOUN
bam-4803	20	11	of	of	ADP
bam-4803	20	12	ryr	ryr	NOUN
bam-4803	20	13	channels	channel	NOUN
bam-4803	20	14	,	,	PUNCT
bam-4803	20	15	there	there	PRON
bam-4803	20	16	are	be	VERB
bam-4803	20	17	major	major	ADJ
bam-4803	20	18	gaps	gap	NOUN
bam-4803	20	19	in	in	ADP
bam-4803	20	20	our	our	PRON
bam-4803	20	21	knowledge	knowledge	NOUN
bam-4803	20	22	about	about	ADP
bam-4803	20	23	the	the	DET
bam-4803	20	24	structure	structure	NOUN
bam-4803	20	25	of	of	ADP
bam-4803	20	26	these	these	DET
bam-4803	20	27	ion	ion	NOUN
bam-4803	20	28	channels	channel	NOUN
bam-4803	20	29	,	,	PUNCT
bam-4803	20	30	their	their	PRON
bam-4803	20	31	ion	ion	NOUN
bam-4803	20	32	-	-	PUNCT
bam-4803	20	33	conducting	conduct	VERB
bam-4803	20	34	pore	pore	ADJ
bam-4803	20	35	and	and	CCONJ
bam-4803	20	36	modulator	modulator	NOUN
bam-4803	20	37	-	-	PUNCT
bam-4803	20	38	binding	bind	VERB
bam-4803	20	39	sites	site	NOUN
bam-4803	20	40	,	,	PUNCT
bam-4803	20	41	largely	largely	ADV
bam-4803	20	42	due	due	ADP
bam-4803	20	43	to	to	ADP
bam-4803	20	44	the	the	DET
bam-4803	20	45	lack	lack	NOUN
bam-4803	20	46	of	of	ADP
bam-4803	20	47	atomic	atomic	ADJ
bam-4803	20	48	-	-	PUNCT
bam-4803	20	49	level	level	NOUN
bam-4803	20	50	structural	structural	ADJ
bam-4803	20	51	details	detail	NOUN
bam-4803	20	52	for	for	ADP
bam-4803	20	53	the	the	DET
bam-4803	20	54	entire	entire	ADJ
bam-4803	20	55	channel	channel	NOUN
bam-4803	20	56	assembly	assembly	NOUN
bam-4803	20	57	.	.	PUNCT
bam-4803	21	1	several	several	ADJ
bam-4803	21	2	lowto	lowto	NOUN
bam-4803	21	3	moderate	moderate	ADJ
bam-4803	21	4	-	-	PUNCT
bam-4803	21	5	resolution	resolution	NOUN
bam-4803	21	6	structures	structure	NOUN
bam-4803	21	7	of	of	ADP
bam-4803	21	8	the	the	DET
bam-4803	21	9	full	full	ADJ
bam-4803	21	10	-	-	PUNCT
bam-4803	21	11	length	length	NOUN
bam-4803	21	12	channel	channel	NOUN
bam-4803	21	13	have	have	AUX
bam-4803	21	14	been	be	AUX
bam-4803	21	15	solved	solve	VERB
bam-4803	21	16	and	and	CCONJ
bam-4803	21	17	some	some	DET
bam-4803	21	18	functional	functional	ADJ
bam-4803	21	19	regions	region	NOUN
bam-4803	21	20	mapped	map	VERB
bam-4803	21	21	to	to	ADP
bam-4803	21	22	the	the	DET
bam-4803	21	23	3d	3d	NUM
bam-4803	21	24	structure	structure	NOUN
bam-4803	21	25	.	.	PUNCT
bam-4803	22	1	in	in	ADP
bam-4803	22	2	addition	addition	NOUN
bam-4803	22	3	,	,	PUNCT
bam-4803	22	4	atomic	atomic	ADJ
bam-4803	22	5	models	model	NOUN
bam-4803	22	6	of	of	ADP
bam-4803	22	7	small	small	ADJ
bam-4803	22	8	soluble	soluble	ADJ
bam-4803	22	9	portions	portion	NOUN
bam-4803	22	10	of	of	ADP
bam-4803	22	11	the	the	DET
bam-4803	22	12	channel	channel	NOUN
bam-4803	22	13	have	have	AUX
bam-4803	22	14	also	also	ADV
bam-4803	22	15	been	be	AUX
bam-4803	22	16	determined	determine	VERB
bam-4803	22	17	by	by	ADP
bam-4803	22	18	x	x	NOUN
bam-4803	22	19	-	-	NOUN
bam-4803	22	20	ray	ray	NOUN
bam-4803	22	21	crystallography	crystallography	NOUN
bam-4803	22	22	representing	represent	VERB
bam-4803	22	23	~10	~10	ADP
bam-4803	22	24	%	%	NOUN
bam-4803	22	25	of	of	ADP
bam-4803	22	26	the	the	DET
bam-4803	22	27	entire	entire	ADJ
bam-4803	22	28	protein	protein	NOUN
bam-4803	22	29	.	.	PUNCT
bam-4803	23	1	among	among	ADP
bam-4803	23	2	the	the	DET
bam-4803	23	3	obstacles	obstacle	NOUN
bam-4803	23	4	for	for	ADP
bam-4803	23	5	achieving	achieve	VERB
bam-4803	23	6	a	a	DET
bam-4803	23	7	high	high	ADJ
bam-4803	23	8	-	-	PUNCT
bam-4803	23	9	resolution	resolution	NOUN
bam-4803	23	10	structure	structure	NOUN
bam-4803	23	11	of	of	ADP
bam-4803	23	12	ryr	ryr	NOUN
bam-4803	23	13	channels	channel	NOUN
bam-4803	23	14	are	be	AUX
bam-4803	23	15	its	its	PRON
bam-4803	23	16	inherent	inherent	ADJ
bam-4803	23	17	flexibility	flexibility	NOUN
bam-4803	23	18	and	and	CCONJ
bam-4803	23	19	location	location	NOUN
bam-4803	23	20	within	within	ADP
bam-4803	23	21	the	the	DET
bam-4803	23	22	biological	biological	ADJ
bam-4803	23	23	membrane	membrane	NOUN
bam-4803	23	24	.	.	PUNCT
bam-4803	24	1	ryr	ryr	NOUN
bam-4803	24	2	ion	ion	NOUN
bam-4803	24	3	channels	channel	NOUN
bam-4803	24	4	can	can	AUX
bam-4803	24	5	be	be	AUX
bam-4803	24	6	conceptualized	conceptualize	VERB
bam-4803	24	7	as	as	ADP
bam-4803	24	8	integral	integral	ADJ
bam-4803	24	9	membrane	membrane	NOUN
bam-4803	24	10	scaffolding	scaffolding	NOUN
bam-4803	24	11	protein	protein	NOUN
bam-4803	24	12	assemblies	assembly	NOUN
bam-4803	24	13	that	that	PRON
bam-4803	24	14	function	function	VERB
bam-4803	24	15	in	in	ADP
bam-4803	24	16	tight	tight	ADJ
bam-4803	24	17	association	association	NOUN
bam-4803	24	18	with	with	ADP
bam-4803	24	19	a	a	DET
bam-4803	24	20	large	large	ADJ
bam-4803	24	21	array	array	NOUN
bam-4803	24	22	of	of	ADP
bam-4803	24	23	multiple	multiple	ADJ
bam-4803	24	24	intracellular	intracellular	ADJ
bam-4803	24	25	modulatory	modulatory	ADJ
bam-4803	24	26	proteins	protein	NOUN
bam-4803	24	27	/	/	SYM
bam-4803	24	28	ligands	ligand	NOUN
bam-4803	24	29	,	,	PUNCT
bam-4803	24	30	interacting	interact	VERB
bam-4803	24	31	with	with	ADP
bam-4803	24	32	the	the	DET
bam-4803	24	33	channel	channel	NOUN
bam-4803	24	34	complex	complex	NOUN
bam-4803	24	35	in	in	ADP
bam-4803	24	36	a	a	DET
bam-4803	24	37	dynamic	dynamic	ADJ
bam-4803	24	38	manner	manner	NOUN
bam-4803	24	39	to	to	PART
bam-4803	24	40	provide	provide	VERB
bam-4803	24	41	specific	specific	ADJ
bam-4803	24	42	functional	functional	ADJ
bam-4803	24	43	feedback	feedback	NOUN
bam-4803	24	44	.	.	PUNCT
bam-4803	25	1	thus	thus	ADV
bam-4803	25	2	,	,	PUNCT
bam-4803	25	3	obtaining	obtain	VERB
bam-4803	25	4	biochemically	biochemically	ADV
bam-4803	25	5	homogeneous	homogeneous	ADJ
bam-4803	25	6	and	and	CCONJ
bam-4803	25	7	functionally	functionally	ADV
bam-4803	25	8	stable	stable	ADJ
bam-4803	25	9	channel	channel	NOUN
bam-4803	25	10	protein	protein	NOUN
bam-4803	25	11	from	from	ADP
bam-4803	25	12	its	its	PRON
bam-4803	25	13	native	native	ADJ
bam-4803	25	14	source	source	NOUN
bam-4803	25	15	(	(	PUNCT
bam-4803	25	16	i.e.	i.e.	X
bam-4803	25	17	muscle	muscle	NOUN
bam-4803	25	18	cell	cell	NOUN
bam-4803	25	19	)	)	PUNCT
bam-4803	25	20	suitable	suitable	ADJ
bam-4803	25	21	for	for	ADP
bam-4803	25	22	structure	structure	NOUN
bam-4803	25	23	determination	determination	NOUN
bam-4803	25	24	by	by	ADP
bam-4803	25	25	single	single	ADJ
bam-4803	25	26	-	-	PUNCT
bam-4803	25	27	particle	particle	NOUN
bam-4803	25	28	cryo	cryo	NOUN
bam-4803	25	29	-	-	PUNCT
bam-4803	25	30	em	em	PROPN
bam-4803	25	31	,	,	PUNCT
bam-4803	25	32	remains	remain	VERB
bam-4803	25	33	one	one	NUM
bam-4803	25	34	of	of	ADP
bam-4803	25	35	the	the	DET
bam-4803	25	36	major	major	ADJ
bam-4803	25	37	challenges	challenge	NOUN
bam-4803	25	38	in	in	ADP
bam-4803	25	39	pursuit	pursuit	NOUN
bam-4803	25	40	of	of	ADP
bam-4803	25	41	a	a	DET
bam-4803	25	42	high	high	ADJ
bam-4803	25	43	-	-	PUNCT
bam-4803	25	44	resolution	resolution	NOUN
bam-4803	25	45	structure	structure	NOUN
bam-4803	25	46	of	of	ADP
bam-4803	25	47	the	the	DET
bam-4803	25	48	entire	entire	ADJ
bam-4803	25	49	ryr	ryr	NOUN
bam-4803	25	50	channel	channel	NOUN
bam-4803	25	51	.	.	PUNCT
bam-4803	26	1	detergents	detergent	NOUN
bam-4803	26	2	are	be	AUX
bam-4803	26	3	traditionally	traditionally	ADV
bam-4803	26	4	used	use	VERB
bam-4803	26	5	to	to	PART
bam-4803	26	6	make	make	VERB
bam-4803	26	7	membrane	membrane	ADJ
bam-4803	26	8	proteins	protein	NOUN
bam-4803	26	9	water	water	NOUN
bam-4803	26	10	soluble	soluble	ADJ
bam-4803	26	11	and	and	CCONJ
bam-4803	26	12	suitable	suitable	ADJ
bam-4803	26	13	for	for	ADP
bam-4803	26	14	xray	xray	ADJ
bam-4803	26	15	crystallography	crystallography	NOUN
bam-4803	26	16	,	,	PUNCT
bam-4803	26	17	nmr	nmr	NOUN
bam-4803	26	18	or	or	CCONJ
bam-4803	26	19	cryo	cryo	NOUN
bam-4803	26	20	-	-	PUNCT
bam-4803	26	21	em	em	PROPN
bam-4803	26	22	.	.	PUNCT
bam-4803	27	1	however	however	ADV
bam-4803	27	2	,	,	PUNCT
bam-4803	27	3	detergents	detergent	NOUN
bam-4803	27	4	tend	tend	VERB
bam-4803	27	5	to	to	PART
bam-4803	27	6	destabilize	destabilize	VERB
bam-4803	27	7	and	and	CCONJ
bam-4803	27	8	inactivate	inactivate	VERB
bam-4803	27	9	membrane	membrane	NOUN
bam-4803	27	10	proteins	protein	NOUN
bam-4803	27	11	.	.	PUNCT
bam-4803	28	1	17	17	NUM
bam-4803	29	1	while	while	SCONJ
bam-4803	29	2	single	single	ADJ
bam-4803	29	3	-	-	PUNCT
bam-4803	29	4	particle	particle	NOUN
bam-4803	29	5	cryo	cryo	NOUN
bam-4803	29	6	-	-	PUNCT
bam-4803	29	7	em	em	PRON
bam-4803	29	8	remains	remain	VERB
bam-4803	29	9	the	the	DET
bam-4803	29	10	most	most	ADV
bam-4803	29	11	viable	viable	ADJ
bam-4803	29	12	methodology	methodology	NOUN
bam-4803	29	13	for	for	ADP
bam-4803	29	14	structural	structural	ADJ
bam-4803	29	15	analysis	analysis	NOUN
bam-4803	29	16	of	of	ADP
bam-4803	29	17	large	large	ADJ
bam-4803	29	18	membrane	membrane	NOUN
bam-4803	29	19	protein	protein	NOUN
bam-4803	29	20	complexes	complex	NOUN
bam-4803	29	21	such	such	ADJ
bam-4803	29	22	as	as	ADP
bam-4803	29	23	ryrs	ryr	NOUN
bam-4803	29	24	,	,	PUNCT
bam-4803	29	25	the	the	DET
bam-4803	29	26	presence	presence	NOUN
bam-4803	29	27	of	of	ADP
bam-4803	29	28	detergent	detergent	NOUN
bam-4803	29	29	in	in	ADP
bam-4803	29	30	the	the	DET
bam-4803	29	31	buffer	buffer	NOUN
bam-4803	29	32	is	be	AUX
bam-4803	29	33	an	an	DET
bam-4803	29	34	impediment	impediment	NOUN
bam-4803	29	35	to	to	ADP
bam-4803	29	36	producing	produce	VERB
bam-4803	29	37	high	high	ADJ
bam-4803	29	38	-	-	PUNCT
bam-4803	29	39	resolution	resolution	NOUN
bam-4803	29	40	cryo	cryo	NOUN
bam-4803	29	41	-	-	PUNCT
bam-4803	29	42	em	em	PRON
bam-4803	29	43	structures	structure	NOUN
bam-4803	29	44	of	of	ADP
bam-4803	29	45	membrane	membrane	NOUN
bam-4803	29	46	proteins	protein	NOUN
bam-4803	29	47	.	.	PUNCT
bam-4803	30	1	this	this	DET
bam-4803	30	2	review	review	NOUN
bam-4803	30	3	will	will	AUX
bam-4803	30	4	focus	focus	VERB
bam-4803	30	5	on	on	ADP
bam-4803	30	6	the	the	DET
bam-4803	30	7	structure	structure	NOUN
bam-4803	30	8	determination	determination	NOUN
bam-4803	30	9	of	of	ADP
bam-4803	30	10	the	the	DET
bam-4803	30	11	ca	ca	NOUN
bam-4803	30	12	2	2	NUM
bam-4803	30	13	+	+	NOUN
bam-4803	30	14	release	release	NOUN
bam-4803	30	15	channel	channel	NOUN
bam-4803	30	16	by	by	ADP
bam-4803	30	17	single	single	ADJ
bam-4803	30	18	-	-	PUNCT
bam-4803	30	19	particle	particle	NOUN
bam-4803	30	20	cryo	cryo	NOUN
bam-4803	30	21	-	-	PUNCT
bam-4803	30	22	em	em	PROPN
bam-4803	30	23	with	with	ADP
bam-4803	30	24	an	an	DET
bam-4803	30	25	emphasis	emphasis	NOUN
bam-4803	30	26	on	on	ADP
bam-4803	30	27	cryospecimen	cryospeciman	NOUN
bam-4803	30	28	preparation	preparation	NOUN
bam-4803	30	29	.	.	PUNCT
bam-4803	31	1	we	we	PRON
bam-4803	31	2	will	will	AUX
bam-4803	31	3	discuss	discuss	VERB
bam-4803	31	4	how	how	SCONJ
bam-4803	31	5	the	the	DET
bam-4803	31	6	choice	choice	NOUN
bam-4803	31	7	of	of	ADP
bam-4803	31	8	surfactant	surfactant	NOUN
bam-4803	31	9	may	may	AUX
bam-4803	31	10	affect	affect	VERB
bam-4803	31	11	cryospecimen	cryospeciman	NOUN
bam-4803	31	12	preparation	preparation	NOUN
bam-4803	31	13	and	and	CCONJ
bam-4803	31	14	the	the	DET
bam-4803	31	15	success	success	NOUN
bam-4803	31	16	of	of	ADP
bam-4803	31	17	cryo	cryo	NOUN
bam-4803	31	18	-	-	PUNCT
bam-4803	31	19	em	em	PRON
bam-4803	31	20	imaging	imaging	NOUN
bam-4803	31	21	of	of	ADP
bam-4803	31	22	membrane	membrane	NOUN
bam-4803	31	23	proteins	protein	NOUN
bam-4803	31	24	.	.	PUNCT
bam-4803	32	1	ryanodine	ryanodine	NOUN
bam-4803	32	2	receptor	receptor	NOUN
bam-4803	32	3	biology	biology	NOUN
bam-4803	32	4	–	–	PUNCT
bam-4803	32	5	from	from	ADP
bam-4803	32	6	discovery	discovery	NOUN
bam-4803	32	7	to	to	PART
bam-4803	32	8	structure	structure	VERB
bam-4803	32	9	the	the	DET
bam-4803	32	10	ryanodine	ryanodine	NOUN
bam-4803	32	11	receptor	receptor	NOUN
bam-4803	32	12	is	be	AUX
bam-4803	32	13	an	an	DET
bam-4803	32	14	intracellular	intracellular	ADJ
bam-4803	32	15	ca	ca	NOUN
bam-4803	32	16	2	2	NUM
bam-4803	32	17	+	+	NOUN
bam-4803	32	18	release	release	NOUN
bam-4803	32	19	channel	channel	NOUN
bam-4803	32	20	that	that	PRON
bam-4803	32	21	resides	reside	VERB
bam-4803	32	22	in	in	ADP
bam-4803	32	23	the	the	DET
bam-4803	32	24	sarcoplasmic	sarcoplasmic	NOUN
bam-4803	32	25	reticulum	reticulum	NOUN
bam-4803	32	26	(	(	PUNCT
bam-4803	32	27	sr	sr	NOUN
bam-4803	32	28	)	)	PUNCT
bam-4803	32	29	membrane	membrane	NOUN
bam-4803	32	30	and	and	CCONJ
bam-4803	32	31	is	be	AUX
bam-4803	32	32	integral	integral	ADJ
bam-4803	32	33	to	to	ADP
bam-4803	32	34	the	the	DET
bam-4803	32	35	ca	ca	NOUN
bam-4803	32	36	2	2	NUM
bam-4803	32	37	+	+	NOUN
bam-4803	32	38	dependent	dependent	ADJ
bam-4803	32	39	signaling	signal	VERB
bam-4803	32	40	process	process	NOUN
bam-4803	32	41	of	of	ADP
bam-4803	32	42	muscle	muscle	NOUN
bam-4803	32	43	contraction	contraction	NOUN
bam-4803	32	44	.	.	PUNCT
bam-4803	33	1	in	in	ADP
bam-4803	33	2	skeletal	skeletal	ADJ
bam-4803	33	3	muscle	muscle	NOUN
bam-4803	33	4	,	,	PUNCT
bam-4803	33	5	type	type	NOUN
bam-4803	33	6	1	1	NUM
bam-4803	33	7	ryr	ryr	NOUN
bam-4803	33	8	(	(	PUNCT
bam-4803	33	9	ryr1	ryr1	NOUN
bam-4803	33	10	)	)	PUNCT
bam-4803	33	11	forms	form	VERB
bam-4803	33	12	a	a	DET
bam-4803	33	13	macromolecular	macromolecular	ADJ
bam-4803	33	14	complex	complex	NOUN
bam-4803	33	15	with	with	ADP
bam-4803	33	16	voltage	voltage	NOUN
bam-4803	33	17	-	-	PUNCT
bam-4803	33	18	gated	gate	VERB
bam-4803	33	19	ca	ca	NOUN
bam-4803	33	20	2	2	NUM
bam-4803	33	21	+	+	NUM
bam-4803	33	22	channels	channel	NOUN
bam-4803	33	23	,	,	PUNCT
bam-4803	33	24	cav1.1	cav1.1	NOUN
bam-4803	33	25	,	,	PUNCT
bam-4803	33	26	located	locate	VERB
bam-4803	33	27	in	in	ADP
bam-4803	33	28	the	the	DET
bam-4803	33	29	adjacent	adjacent	ADJ
bam-4803	33	30	t	t	PROPN
bam-4803	33	31	-	-	PUNCT
bam-4803	33	32	tubule	tubule	NOUN
bam-4803	33	33	membrane	membrane	NOUN
bam-4803	33	34	,	,	PUNCT
bam-4803	33	35	whereby	whereby	SCONJ
bam-4803	33	36	cav1.1	cav1.1	NOUN
bam-4803	33	37	senses	sense	VERB
bam-4803	33	38	membrane	membrane	ADJ
bam-4803	33	39	depolarization	depolarization	NOUN
bam-4803	33	40	and	and	CCONJ
bam-4803	33	41	transmits	transmit	VERB
bam-4803	33	42	a	a	DET
bam-4803	33	43	mechanical	mechanical	ADJ
bam-4803	33	44	signal	signal	NOUN
bam-4803	33	45	to	to	PART
bam-4803	33	46	ryr1	ryr1	NOUN
bam-4803	33	47	resulting	result	VERB
bam-4803	33	48	in	in	ADP
bam-4803	33	49	the	the	DET
bam-4803	33	50	release	release	NOUN
bam-4803	33	51	of	of	ADP
bam-4803	33	52	ca	ca	NOUN
bam-4803	33	53	2	2	NUM
bam-4803	33	54	+	+	NOUN
bam-4803	33	55	ions	ion	NOUN
bam-4803	33	56	from	from	ADP
bam-4803	33	57	sr	sr	PROPN
bam-4803	33	58	stores	store	NOUN
bam-4803	33	59	through	through	ADP
bam-4803	33	60	ryr1	ryr1	NOUN
bam-4803	33	61	.	.	PUNCT
bam-4803	34	1	the	the	DET
bam-4803	34	2	voltagemediated	voltagemediate	VERB
bam-4803	34	3	rapid	rapid	ADJ
bam-4803	34	4	release	release	NOUN
bam-4803	34	5	of	of	ADP
bam-4803	34	6	ca	ca	NOUN
bam-4803	34	7	2	2	NUM
bam-4803	34	8	+	+	CCONJ
bam-4803	34	9	into	into	ADP
bam-4803	34	10	the	the	DET
bam-4803	34	11	cytosol	cytosol	NOUN
bam-4803	34	12	from	from	ADP
bam-4803	34	13	sr	sr	PROPN
bam-4803	34	14	stores	store	NOUN
bam-4803	34	15	allows	allow	VERB
bam-4803	34	16	for	for	SCONJ
bam-4803	34	17	the	the	DET
bam-4803	34	18	contractile	contractile	NOUN
bam-4803	34	19	apparatus	apparatus	NOUN
bam-4803	34	20	to	to	PART
bam-4803	34	21	operate	operate	VERB
bam-4803	34	22	,	,	PUNCT
bam-4803	34	23	a	a	DET
bam-4803	34	24	process	process	NOUN
bam-4803	34	25	called	call	VERB
bam-4803	34	26	excitation	excitation	NOUN
bam-4803	34	27	-	-	PUNCT
bam-4803	34	28	contraction	contraction	NOUN
bam-4803	34	29	coupling	coupling	NOUN
bam-4803	34	30	.	.	PUNCT
bam-4803	35	1	excitation	excitation	NOUN
bam-4803	35	2	-	-	PUNCT
bam-4803	35	3	contraction	contraction	NOUN
bam-4803	35	4	coupling	coupling	NOUN
bam-4803	35	5	in	in	ADP
bam-4803	35	6	cardiac	cardiac	ADJ
bam-4803	35	7	muscle	muscle	NOUN
bam-4803	35	8	differs	differ	VERB
bam-4803	35	9	in	in	ADP
bam-4803	35	10	that	that	SCONJ
bam-4803	35	11	the	the	DET
bam-4803	35	12	voltage	voltage	NOUN
bam-4803	35	13	sensor	sensor	NOUN
bam-4803	35	14	is	be	AUX
bam-4803	35	15	not	not	PART
bam-4803	35	16	physically	physically	ADV
bam-4803	35	17	coupled	couple	VERB
bam-4803	35	18	to	to	ADP
bam-4803	35	19	the	the	DET
bam-4803	35	20	ca	ca	NOUN
bam-4803	35	21	2	2	NUM
bam-4803	35	22	+	+	NOUN
bam-4803	35	23	release	release	NOUN
bam-4803	35	24	channel	channel	NOUN
bam-4803	35	25	,	,	PUNCT
bam-4803	35	26	instead	instead	ADV
bam-4803	35	27	,	,	PUNCT
bam-4803	35	28	coupling	couple	VERB
bam-4803	35	29	relies	rely	VERB
bam-4803	35	30	upon	upon	SCONJ
bam-4803	35	31	ca	ca	NOUN
bam-4803	35	32	2	2	NUM
bam-4803	35	33	+	+	NOUN
bam-4803	35	34	entry	entry	NOUN
bam-4803	35	35	through	through	ADP
bam-4803	35	36	the	the	DET
bam-4803	35	37	cav1.2	cav1.2	NOUN
bam-4803	35	38	channel	channel	NOUN
bam-4803	35	39	to	to	PART
bam-4803	35	40	initiate	initiate	VERB
bam-4803	35	41	type	type	NOUN
bam-4803	35	42	2	2	NUM
bam-4803	35	43	ryr	ryr	NOUN
bam-4803	35	44	(	(	PUNCT
bam-4803	35	45	ryr2	ryr2	NOUN
bam-4803	35	46	)	)	PUNCT
bam-4803	35	47	openings	opening	NOUN
bam-4803	35	48	.	.	PUNCT
bam-4803	36	1	disruption	disruption	NOUN
bam-4803	36	2	of	of	ADP
bam-4803	36	3	excitation	excitation	NOUN
bam-4803	36	4	-	-	PUNCT
bam-4803	36	5	contraction	contraction	NOUN
bam-4803	36	6	coupling	coupling	NOUN
bam-4803	36	7	can	can	AUX
bam-4803	36	8	result	result	VERB
bam-4803	36	9	in	in	ADP
bam-4803	36	10	several	several	ADJ
bam-4803	36	11	pathological	pathological	ADJ
bam-4803	36	12	consequences	consequence	NOUN
bam-4803	36	13	.	.	PUNCT
bam-4803	37	1	mice	mouse	NOUN
bam-4803	37	2	lacking	lack	VERB
bam-4803	37	3	ryr1	ryr1	NOUN
bam-4803	37	4	or	or	CCONJ
bam-4803	37	5	ryr2	ryr2	NOUN
bam-4803	37	6	protein	protein	NOUN
bam-4803	37	7	expression	expression	NOUN
bam-4803	37	8	die	die	VERB
bam-4803	37	9	either	either	CCONJ
bam-4803	37	10	prenatally	prenatally	ADV
bam-4803	37	11	or	or	CCONJ
bam-4803	37	12	perinatal	perinatal	ADJ
bam-4803	37	13	.	.	PUNCT
bam-4803	38	1	18,19	18,19	NUM
bam-4803	38	2	mutations	mutation	NOUN
bam-4803	38	3	in	in	ADP
bam-4803	38	4	the	the	DET
bam-4803	38	5	ryr	ryr	NOUN
bam-4803	38	6	channel	channel	NOUN
bam-4803	38	7	protein	protein	NOUN
bam-4803	38	8	can	can	AUX
bam-4803	38	9	cause	cause	VERB
bam-4803	38	10	abnormal	abnormal	ADJ
bam-4803	38	11	ca	ca	NOUN
bam-4803	38	12	2	2	NUM
bam-4803	38	13	+	+	NOUN
bam-4803	38	14	handling	handling	NOUN
bam-4803	38	15	and	and	CCONJ
bam-4803	38	16	lead	lead	VERB
bam-4803	38	17	to	to	ADP
bam-4803	38	18	several	several	ADJ
bam-4803	38	19	conditions	condition	NOUN
bam-4803	38	20	in	in	ADP
bam-4803	38	21	humans	human	NOUN
bam-4803	38	22	including	include	VERB
bam-4803	38	23	malignant	malignant	ADJ
bam-4803	38	24	hyperthermia	hyperthermia	NOUN
bam-4803	38	25	,	,	PUNCT
bam-4803	38	26	central	central	ADJ
bam-4803	38	27	core	core	NOUN
bam-4803	38	28	disease	disease	NOUN
bam-4803	38	29	,	,	PUNCT
bam-4803	38	30	multi	multi	ADJ
bam-4803	38	31	-	-	ADJ
bam-4803	38	32	minicore	minicore	ADJ
bam-4803	38	33	disease	disease	NOUN
bam-4803	38	34	,	,	PUNCT
bam-4803	38	35	catecholaminergic	catecholaminergic	ADJ
bam-4803	38	36	polymorphic	polymorphic	ADJ
bam-4803	38	37	ventricular	ventricular	ADJ
bam-4803	38	38	tachycardia	tachycardia	NOUN
bam-4803	38	39	and	and	CCONJ
bam-4803	38	40	arrhythmogenic	arrhythmogenic	ADJ
bam-4803	38	41	right	right	ADJ
bam-4803	38	42	ventricular	ventricular	NOUN
bam-4803	38	43	cardiomyopathy	cardiomyopathy	ADJ
bam-4803	38	44	.	.	PUNCT
bam-4803	39	1	20	20	NUM
bam-4803	39	2	structure	structure	NOUN
bam-4803	39	3	-	-	PUNCT
bam-4803	39	4	function	function	NOUN
bam-4803	39	5	studies	study	NOUN
bam-4803	39	6	of	of	ADP
bam-4803	39	7	ryr	ryr	NOUN
bam-4803	39	8	to	to	ADP
bam-4803	39	9	date	date	NOUN
bam-4803	39	10	have	have	AUX
bam-4803	39	11	been	be	AUX
bam-4803	39	12	conducted	conduct	VERB
bam-4803	39	13	in	in	ADP
bam-4803	39	14	the	the	DET
bam-4803	39	15	absence	absence	NOUN
bam-4803	39	16	of	of	ADP
bam-4803	39	17	highresolution	highresolution	NOUN
bam-4803	39	18	information	information	NOUN
bam-4803	39	19	about	about	ADP
bam-4803	39	20	the	the	DET
bam-4803	39	21	molecular	molecular	ADJ
bam-4803	39	22	arrangement	arrangement	NOUN
bam-4803	39	23	of	of	ADP
bam-4803	39	24	the	the	DET
bam-4803	39	25	channel	channel	NOUN
bam-4803	39	26	,	,	PUNCT
bam-4803	39	27	yet	yet	CCONJ
bam-4803	39	28	this	this	DET
bam-4803	39	29	level	level	NOUN
bam-4803	39	30	of	of	ADP
bam-4803	39	31	information	information	NOUN
bam-4803	39	32	is	be	AUX
bam-4803	39	33	necessary	necessary	ADJ
bam-4803	39	34	to	to	PART
bam-4803	39	35	understand	understand	VERB
bam-4803	39	36	the	the	DET
bam-4803	39	37	molecular	molecular	ADJ
bam-4803	39	38	basis	basis	NOUN
bam-4803	39	39	for	for	ADP
bam-4803	39	40	excitation	excitation	NOUN
bam-4803	39	41	-	-	PUNCT
bam-4803	39	42	contraction	contraction	NOUN
bam-4803	39	43	coupling	coupling	NOUN
bam-4803	39	44	and	and	CCONJ
bam-4803	39	45	channel	channel	NOUN
bam-4803	39	46	dysfunction	dysfunction	NOUN
bam-4803	39	47	.	.	PUNCT
bam-4803	40	1	the	the	DET
bam-4803	40	2	ryr	ryr	NOUN
bam-4803	40	3	channel	channel	NOUN
bam-4803	40	4	functions	function	NOUN
bam-4803	40	5	as	as	ADP
bam-4803	40	6	a	a	DET
bam-4803	40	7	homotetrameric	homotetrameric	ADJ
bam-4803	40	8	channel	channel	NOUN
bam-4803	40	9	with	with	ADP
bam-4803	40	10	a	a	DET
bam-4803	40	11	total	total	ADJ
bam-4803	40	12	molecular	molecular	ADJ
bam-4803	40	13	mass	mass	NOUN
bam-4803	40	14	of	of	ADP
bam-4803	40	15	2.3	2.3	NUM
bam-4803	40	16	mda	mda	NOUN
bam-4803	40	17	,	,	PUNCT
bam-4803	40	18	each	each	DET
bam-4803	40	19	monomer	monomer	NOUN
bam-4803	40	20	containing	contain	VERB
bam-4803	40	21	~5000	~5000	NUM
bam-4803	40	22	amino	amino	ADJ
bam-4803	40	23	acids	acid	NOUN
bam-4803	40	24	.	.	PUNCT
bam-4803	41	1	the	the	DET
bam-4803	41	2	channel	channel	NOUN
bam-4803	41	3	consists	consist	VERB
bam-4803	41	4	of	of	ADP
bam-4803	41	5	a	a	DET
bam-4803	41	6	large	large	ADJ
bam-4803	41	7	cytoplasmic	cytoplasmic	ADJ
bam-4803	41	8	n	n	CCONJ
bam-4803	41	9	-	-	PUNCT
bam-4803	41	10	terminal	terminal	ADJ
bam-4803	41	11	region	region	NOUN
bam-4803	41	12	(	(	PUNCT
bam-4803	41	13	~80	~80	NOUN
bam-4803	41	14	%	%	NOUN
bam-4803	41	15	of	of	ADP
bam-4803	41	16	the	the	DET
bam-4803	41	17	protein	protein	NOUN
bam-4803	41	18	mass	mass	PROPN
bam-4803	41	19	)	)	PUNCT
bam-4803	41	20	,	,	PUNCT
bam-4803	41	21	several	several	ADJ
bam-4803	41	22	membranespanning	membranespanne	VERB
bam-4803	41	23	segments	segment	NOUN
bam-4803	41	24	and	and	CCONJ
bam-4803	41	25	a	a	DET
bam-4803	41	26	small	small	ADJ
bam-4803	41	27	cytoplasmic	cytoplasmic	ADJ
bam-4803	41	28	cterminus	cterminus	NOUN
bam-4803	41	29	.	.	PUNCT
bam-4803	42	1	the	the	DET
bam-4803	42	2	n	n	CCONJ
bam-4803	42	3	-	-	PUNCT
bam-4803	42	4	terminal	terminal	ADJ
bam-4803	42	5	domain	domain	NOUN
bam-4803	42	6	serves	serve	VERB
bam-4803	42	7	as	as	ADP
bam-4803	42	8	a	a	DET
bam-4803	42	9	scaffold	scaffold	NOUN
bam-4803	42	10	for	for	ADP
bam-4803	42	11	many	many	ADJ
bam-4803	42	12	regulatory	regulatory	ADJ
bam-4803	42	13	proteins	protein	NOUN
bam-4803	42	14	and	and	CCONJ
bam-4803	42	15	molecules	molecule	NOUN
bam-4803	42	16	to	to	PART
bam-4803	42	17	bind	bind	VERB
bam-4803	42	18	,	,	PUNCT
bam-4803	42	19	including	include	VERB
bam-4803	42	20	ca	ca	NOUN
bam-4803	42	21	2	2	NUM
bam-4803	42	22	+	+	NUM
bam-4803	42	23	,	,	PUNCT
bam-4803	42	24	atp	atp	PROPN
bam-4803	42	25	,	,	PUNCT
bam-4803	42	26	caffeine	caffeine	NOUN
bam-4803	42	27	,	,	PUNCT
bam-4803	42	28	mg	mg	PROPN
bam-4803	42	29	2	2	NUM
bam-4803	42	30	+	+	NUM
bam-4803	42	31	,	,	PUNCT
bam-4803	42	32	pka	pka	PROPN
bam-4803	42	33	,	,	PUNCT
bam-4803	42	34	ryanodine	ryanodine	NOUN
bam-4803	42	35	,	,	PUNCT
bam-4803	42	36	calmodulin	calmodulin	NOUN
bam-4803	42	37	,	,	PUNCT
bam-4803	42	38	fk506	fk506	NOUN
bam-4803	42	39	binding	bind	VERB
bam-4803	42	40	protein	protein	NOUN
bam-4803	42	41	and	and	CCONJ
bam-4803	42	42	cav1.1	cav1.1	NOUN
bam-4803	42	43	.	.	PUNCT
bam-4803	43	1	the	the	DET
bam-4803	43	2	transmembrane	transmembrane	ADJ
bam-4803	43	3	region	region	NOUN
bam-4803	43	4	of	of	ADP
bam-4803	43	5	ryr	ryr	PROPN
bam-4803	43	6	contains	contain	VERB
bam-4803	43	7	the	the	DET
bam-4803	43	8	ionconducting	ionconducte	VERB
bam-4803	43	9	pore	pore	NOUN
bam-4803	43	10	across	across	ADP
bam-4803	43	11	the	the	DET
bam-4803	43	12	sr	sr	PROPN
bam-4803	43	13	membrane	membrane	NOUN
bam-4803	43	14	,	,	PUNCT
bam-4803	43	15	and	and	CCONJ
bam-4803	43	16	based	base	VERB
bam-4803	43	17	on	on	ADP
bam-4803	43	18	sequence	sequence	NOUN
bam-4803	43	19	analysis	analysis	NOUN
bam-4803	43	20	the	the	DET
bam-4803	43	21	channel	channel	NOUN
bam-4803	43	22	is	be	AUX
bam-4803	43	23	predicted	predict	VERB
bam-4803	43	24	to	to	PART
bam-4803	43	25	contain	contain	VERB
bam-4803	43	26	an	an	DET
bam-4803	43	27	even	even	ADJ
bam-4803	43	28	number	number	NOUN
bam-4803	43	29	of	of	ADP
bam-4803	43	30	membrane	membrane	NOUN
bam-4803	43	31	spanning	span	VERB
bam-4803	43	32	helices	helix	NOUN
bam-4803	43	33	per	per	ADP
bam-4803	43	34	subunit	subunit	NOUN
bam-4803	43	35	,	,	PUNCT
bam-4803	43	36	likely	likely	ADV
bam-4803	43	37	between	between	ADP
bam-4803	43	38	4	4	NUM
bam-4803	43	39	and	and	CCONJ
bam-4803	43	40	12	12	NUM
bam-4803	43	41	,	,	PUNCT
bam-4803	43	42	encompassed	encompass	VERB
bam-4803	43	43	within	within	ADP
bam-4803	43	44	the	the	DET
bam-4803	43	45	amino	amino	NOUN
bam-4803	43	46	acid	acid	NOUN
bam-4803	43	47	sequence	sequence	NOUN
bam-4803	43	48	3985	3985	NUM
bam-4803	43	49	-	-	SYM
bam-4803	43	50	4940	4940	NUM
bam-4803	43	51	.	.	PUNCT
bam-4803	44	1	21	21	NUM
bam-4803	44	2	-	-	SYM
bam-4803	44	3	24	24	NUM
bam-4803	44	4	however	however	ADV
bam-4803	44	5	,	,	PUNCT
bam-4803	44	6	the	the	DET
bam-4803	44	7	exact	exact	ADJ
bam-4803	44	8	number	number	NOUN
bam-4803	44	9	of	of	ADP
bam-4803	44	10	transmembrane	transmembrane	ADJ
bam-4803	44	11	helices	helix	NOUN
bam-4803	44	12	has	have	VERB
bam-4803	44	13	yet	yet	ADV
bam-4803	44	14	to	to	PART
bam-4803	44	15	be	be	AUX
bam-4803	44	16	confirmed	confirm	VERB
bam-4803	44	17	by	by	ADP
bam-4803	44	18	direct	direct	ADJ
bam-4803	44	19	structural	structural	ADJ
bam-4803	44	20	analysis	analysis	NOUN
bam-4803	44	21	of	of	ADP
bam-4803	44	22	the	the	DET
bam-4803	44	23	channel	channel	NOUN
bam-4803	44	24	.	.	PUNCT
bam-4803	45	1	three	three	NUM
bam-4803	45	2	mammalian	mammalian	ADJ
bam-4803	45	3	isoforms	isoform	NOUN
bam-4803	45	4	of	of	ADP
bam-4803	45	5	ryr	ryr	NOUN
bam-4803	45	6	exist	exist	NOUN
bam-4803	45	7	(	(	PUNCT
bam-4803	45	8	ryr1	ryr1	NOUN
bam-4803	45	9	-	-	PUNCT
bam-4803	45	10	3	3	NUM
bam-4803	45	11	)	)	PUNCT
bam-4803	45	12	and	and	CCONJ
bam-4803	45	13	have	have	VERB
bam-4803	45	14	a	a	DET
bam-4803	45	15	relatively	relatively	ADV
bam-4803	45	16	high	high	ADJ
bam-4803	45	17	amino	amino	NOUN
bam-4803	45	18	acid	acid	NOUN
bam-4803	45	19	sequence	sequence	NOUN
bam-4803	45	20	homology	homology	NOUN
bam-4803	45	21	(	(	PUNCT
bam-4803	45	22	~65	~65	NOUN
bam-4803	45	23	%	%	NOUN
bam-4803	45	24	)	)	PUNCT
bam-4803	45	25	.	.	PUNCT
bam-4803	46	1	divergent	divergent	ADJ
bam-4803	46	2	sequences	sequence	NOUN
bam-4803	46	3	single	single	ADJ
bam-4803	46	4	-	-	PUNCT
bam-4803	46	5	particle	particle	NOUN
bam-4803	46	6	cryo	cryo	NOUN
bam-4803	46	7	-	-	PUNCT
bam-4803	46	8	em	em	PRON
bam-4803	46	9	of	of	ADP
bam-4803	46	10	the	the	DET
bam-4803	46	11	ryanodine	ryanodine	PROPN
bam-4803	46	12	receptor	receptor	NOUN
bam-4803	46	13	channel	channel	PROPN
bam-4803	46	14	eur	eur	PROPN
bam-4803	46	15	j	j	PROPN
bam-4803	46	16	transl	transl	PROPN
bam-4803	46	17	myol	myol	PROPN
bam-4803	46	18	basic	basic	ADJ
bam-4803	46	19	appl	appl	NOUN
bam-4803	46	20	myol	myol	NOUN
bam-4803	46	21	2015	2015	NUM
bam-4803	46	22	;	;	PUNCT
bam-4803	46	23	25	25	NUM
bam-4803	46	24	(	(	PUNCT
bam-4803	46	25	1	1	NUM
bam-4803	46	26	):	):	PUNCT
bam-4803	46	27	35	35	NUM
bam-4803	46	28	-	-	SYM
bam-4803	46	29	48	48	NUM
bam-4803	46	30	37	37	NUM
bam-4803	46	31	between	between	ADP
bam-4803	46	32	the	the	DET
bam-4803	46	33	three	three	NUM
bam-4803	46	34	isoforms	isoform	NOUN
bam-4803	46	35	occur	occur	VERB
bam-4803	46	36	in	in	ADP
bam-4803	46	37	domains	domain	NOUN
bam-4803	46	38	known	know	VERB
bam-4803	46	39	as	as	ADP
bam-4803	46	40	d1	d1	PROPN
bam-4803	46	41	(	(	PUNCT
bam-4803	46	42	residues	residue	NOUN
bam-4803	46	43	4254	4254	NUM
bam-4803	46	44	-	-	SYM
bam-4803	46	45	4631	4631	NUM
bam-4803	46	46	in	in	ADP
bam-4803	46	47	ryr1	ryr1	NOUN
bam-4803	46	48	)	)	PUNCT
bam-4803	46	49	,	,	PUNCT
bam-4803	46	50	d2	d2	PROPN
bam-4803	46	51	(	(	PUNCT
bam-4803	46	52	residues	residue	NOUN
bam-4803	46	53	13421403	13421403	NUM
bam-4803	46	54	)	)	PUNCT
bam-4803	46	55	and	and	CCONJ
bam-4803	46	56	d3	d3	PROPN
bam-4803	46	57	(	(	PUNCT
bam-4803	46	58	residues	residue	NOUN
bam-4803	46	59	1872	1872	NUM
bam-4803	46	60	-	-	SYM
bam-4803	46	61	1923	1923	NUM
bam-4803	46	62	)	)	PUNCT
bam-4803	46	63	and	and	CCONJ
bam-4803	46	64	are	be	AUX
bam-4803	46	65	likely	likely	ADV
bam-4803	46	66	responsible	responsible	ADJ
bam-4803	46	67	for	for	ADP
bam-4803	46	68	the	the	DET
bam-4803	46	69	differences	difference	NOUN
bam-4803	46	70	in	in	ADP
bam-4803	46	71	regulation	regulation	NOUN
bam-4803	46	72	by	by	ADP
bam-4803	46	73	the	the	DET
bam-4803	46	74	channels	channel	NOUN
bam-4803	46	75	.	.	PUNCT
bam-4803	47	1	ryr1	ryr1	NOUN
bam-4803	47	2	is	be	AUX
bam-4803	47	3	predominantly	predominantly	ADV
bam-4803	47	4	expressed	express	VERB
bam-4803	47	5	in	in	ADP
bam-4803	47	6	skeletal	skeletal	ADJ
bam-4803	47	7	muscle	muscle	NOUN
bam-4803	47	8	;	;	PUNCT
bam-4803	47	9	ryr2	ryr2	NOUN
bam-4803	47	10	is	be	AUX
bam-4803	47	11	predominantly	predominantly	ADV
bam-4803	47	12	expressed	express	VERB
bam-4803	47	13	in	in	ADP
bam-4803	47	14	cardiac	cardiac	ADJ
bam-4803	47	15	muscle	muscle	NOUN
bam-4803	47	16	,	,	PUNCT
bam-4803	47	17	and	and	CCONJ
bam-4803	47	18	ryr3	ryr3	PROPN
bam-4803	47	19	is	be	AUX
bam-4803	47	20	found	find	VERB
bam-4803	47	21	in	in	ADP
bam-4803	47	22	brain	brain	NOUN
bam-4803	47	23	and	and	CCONJ
bam-4803	47	24	diaphragm	diaphragm	NOUN
bam-4803	47	25	.	.	PUNCT
bam-4803	48	1	none	none	NOUN
bam-4803	48	2	of	of	ADP
bam-4803	48	3	the	the	DET
bam-4803	48	4	isoforms	isoform	NOUN
bam-4803	48	5	are	be	AUX
bam-4803	48	6	completely	completely	ADV
bam-4803	48	7	tissue	tissue	NOUN
bam-4803	48	8	specific	specific	ADJ
bam-4803	48	9	,	,	PUNCT
bam-4803	48	10	although	although	SCONJ
bam-4803	48	11	,	,	PUNCT
bam-4803	48	12	ryr1	ryr1	NOUN
bam-4803	48	13	is	be	AUX
bam-4803	48	14	the	the	DET
bam-4803	48	15	most	most	ADV
bam-4803	48	16	thoroughly	thoroughly	ADV
bam-4803	48	17	studied	study	VERB
bam-4803	48	18	isoform	isoform	NOUN
bam-4803	48	19	due	due	ADP
bam-4803	48	20	to	to	ADP
bam-4803	48	21	its	its	PRON
bam-4803	48	22	abundance	abundance	NOUN
bam-4803	48	23	in	in	ADP
bam-4803	48	24	fast	fast	ADJ
bam-4803	48	25	-	-	PUNCT
bam-4803	48	26	twitch	twitch	NOUN
bam-4803	48	27	skeletal	skeletal	ADJ
bam-4803	48	28	muscle	muscle	NOUN
bam-4803	48	29	and	and	CCONJ
bam-4803	48	30	relative	relative	ADJ
bam-4803	48	31	ease	ease	NOUN
bam-4803	48	32	of	of	ADP
bam-4803	48	33	purification	purification	NOUN
bam-4803	48	34	.	.	PUNCT
bam-4803	49	1	the	the	DET
bam-4803	49	2	first	first	ADJ
bam-4803	49	3	visual	visual	ADJ
bam-4803	49	4	documentation	documentation	NOUN
bam-4803	49	5	of	of	ADP
bam-4803	49	6	ryr1	ryr1	NOUN
bam-4803	49	7	occurred	occur	VERB
bam-4803	49	8	over	over	ADP
bam-4803	49	9	40	40	NUM
bam-4803	49	10	years	year	NOUN
bam-4803	49	11	ago	ago	ADV
bam-4803	49	12	where	where	SCONJ
bam-4803	49	13	ryr1	ryr1	NOUN
bam-4803	49	14	was	be	AUX
bam-4803	49	15	identified	identify	VERB
bam-4803	49	16	using	use	VERB
bam-4803	49	17	thinsection	thinsection	NOUN
bam-4803	49	18	electron	electron	NOUN
bam-4803	49	19	microscopy	microscopy	NOUN
bam-4803	49	20	as	as	ADP
bam-4803	49	21	a	a	DET
bam-4803	49	22	large	large	ADJ
bam-4803	49	23	“	"	PUNCT
bam-4803	49	24	foot	foot	NOUN
bam-4803	49	25	”	"	PUNCT
bam-4803	49	26	structure	structure	NOUN
bam-4803	49	27	fig	fig	NOUN
bam-4803	49	28	1	1	NUM
bam-4803	49	29	.	.	PUNCT
bam-4803	49	30	timeline	timeline	NOUN
bam-4803	49	31	summary	summary	NOUN
bam-4803	49	32	of	of	ADP
bam-4803	49	33	ryr1	ryr1	NOUN
bam-4803	49	34	structural	structural	ADJ
bam-4803	49	35	studies	study	NOUN
bam-4803	49	36	.	.	PUNCT
bam-4803	50	1	ryr1	ryr1	PROPN
bam-4803	50	2	was	be	AUX
bam-4803	50	3	first	first	ADV
bam-4803	50	4	identified	identify	VERB
bam-4803	50	5	as	as	ADP
bam-4803	50	6	large	large	ADJ
bam-4803	50	7	electron	electron	NOUN
bam-4803	50	8	-	-	PUNCT
bam-4803	50	9	dense	dense	ADJ
bam-4803	50	10	“	"	PUNCT
bam-4803	50	11	foot	foot	NOUN
bam-4803	50	12	”	"	PUNCT
bam-4803	50	13	observed	observe	VERB
bam-4803	50	14	between	between	ADP
bam-4803	50	15	the	the	DET
bam-4803	50	16	junctions	junction	NOUN
bam-4803	50	17	of	of	ADP
bam-4803	50	18	t	t	NOUN
bam-4803	50	19	-	-	PUNCT
bam-4803	50	20	tubule	tubule	NOUN
bam-4803	50	21	and	and	CCONJ
bam-4803	50	22	sr	sr	PROPN
bam-4803	50	23	membranes	membrane	NOUN
bam-4803	50	24	.	.	PUNCT
bam-4803	51	1	25	25	NUM
bam-4803	51	2	over	over	ADP
bam-4803	51	3	the	the	DET
bam-4803	51	4	next	next	ADJ
bam-4803	51	5	two	two	NUM
bam-4803	51	6	decades	decade	NOUN
bam-4803	51	7	many	many	ADJ
bam-4803	51	8	efforts	effort	NOUN
bam-4803	51	9	were	be	AUX
bam-4803	51	10	made	make	VERB
bam-4803	51	11	to	to	PART
bam-4803	51	12	molecularly	molecularly	ADV
bam-4803	51	13	identify	identify	VERB
bam-4803	51	14	the	the	DET
bam-4803	51	15	structure	structure	NOUN
bam-4803	51	16	observed	observe	VERB
bam-4803	51	17	in	in	ADP
bam-4803	51	18	the	the	DET
bam-4803	51	19	triad	triad	ADJ
bam-4803	51	20	junctions	junction	NOUN
bam-4803	51	21	and	and	CCONJ
bam-4803	51	22	its	its	PRON
bam-4803	51	23	role	role	NOUN
bam-4803	51	24	in	in	ADP
bam-4803	51	25	muscle	muscle	NOUN
bam-4803	51	26	physiology	physiology	NOUN
bam-4803	51	27	.	.	PUNCT
bam-4803	52	1	eventually	eventually	ADV
bam-4803	52	2	,	,	PUNCT
bam-4803	52	3	through	through	ADP
bam-4803	52	4	the	the	DET
bam-4803	52	5	use	use	NOUN
bam-4803	52	6	of	of	ADP
bam-4803	52	7	3	3	NUM
bam-4803	52	8	h	h	NOUN
bam-4803	52	9	-	-	PUNCT
bam-4803	52	10	ryanodine	ryanodine	NOUN
bam-4803	52	11	,	,	PUNCT
bam-4803	52	12	differential	differential	VERB
bam-4803	52	13	centrifugation	centrifugation	NOUN
bam-4803	52	14	and	and	CCONJ
bam-4803	52	15	biophysical	biophysical	ADJ
bam-4803	52	16	characterizations	characterization	NOUN
bam-4803	52	17	,	,	PUNCT
bam-4803	52	18	ryr1	ryr1	NOUN
bam-4803	52	19	was	be	AUX
bam-4803	52	20	solidified	solidify	VERB
bam-4803	52	21	as	as	ADP
bam-4803	52	22	the	the	DET
bam-4803	52	23	intracellular	intracellular	NOUN
bam-4803	52	24	ca	ca	NOUN
bam-4803	52	25	2	2	NUM
bam-4803	52	26	+	+	NOUN
bam-4803	52	27	release	release	NOUN
bam-4803	52	28	channel	channel	NOUN
bam-4803	52	29	responsible	responsible	ADJ
bam-4803	52	30	for	for	ADP
bam-4803	52	31	the	the	DET
bam-4803	52	32	release	release	NOUN
bam-4803	52	33	of	of	ADP
bam-4803	52	34	ca	ca	NOUN
bam-4803	52	35	2	2	NUM
bam-4803	52	36	+	+	NOUN
bam-4803	52	37	preceding	precede	VERB
bam-4803	52	38	muscle	muscle	NOUN
bam-4803	52	39	contraction	contraction	NOUN
bam-4803	52	40	.	.	PUNCT
bam-4803	53	1	27	27	NUM
bam-4803	53	2	-	-	SYM
bam-4803	53	3	29	29	NUM
bam-4803	53	4	due	due	ADP
bam-4803	53	5	to	to	ADP
bam-4803	53	6	its	its	PRON
bam-4803	53	7	relative	relative	ADJ
bam-4803	53	8	ease	ease	NOUN
bam-4803	53	9	of	of	ADP
bam-4803	53	10	purification	purification	NOUN
bam-4803	53	11	and	and	CCONJ
bam-4803	53	12	large	large	ADJ
bam-4803	53	13	size	size	NOUN
bam-4803	53	14	,	,	PUNCT
bam-4803	53	15	the	the	DET
bam-4803	53	16	structure	structure	NOUN
bam-4803	53	17	of	of	ADP
bam-4803	53	18	ryr1	ryr1	NOUN
bam-4803	53	19	was	be	AUX
bam-4803	53	20	investigated	investigate	VERB
bam-4803	53	21	by	by	ADP
bam-4803	53	22	single	single	ADJ
bam-4803	53	23	-	-	PUNCT
bam-4803	53	24	particle	particle	NOUN
bam-4803	53	25	electronmicroscopy	electronmicroscopy	NOUN
bam-4803	53	26	.	.	PUNCT
bam-4803	54	1	the	the	DET
bam-4803	54	2	first	first	ADJ
bam-4803	54	3	3d	3d	NUM
bam-4803	54	4	structure	structure	NOUN
bam-4803	54	5	was	be	AUX
bam-4803	54	6	obtained	obtain	VERB
bam-4803	54	7	by	by	ADP
bam-4803	54	8	negative	negative	ADJ
bam-4803	54	9	stain	stain	NOUN
bam-4803	54	10	microscopy	microscopy	NOUN
bam-4803	54	11	,	,	PUNCT
bam-4803	54	12	reveling	revel	VERB
bam-4803	54	13	basic	basic	ADJ
bam-4803	54	14	morphological	morphological	ADJ
bam-4803	54	15	features	feature	NOUN
bam-4803	54	16	,	,	PUNCT
bam-4803	54	17	albeit	albeit	SCONJ
bam-4803	54	18	in	in	ADP
bam-4803	54	19	a	a	DET
bam-4803	54	20	stained	stain	VERB
bam-4803	54	21	and	and	CCONJ
bam-4803	54	22	dehydrated	dehydrate	VERB
bam-4803	54	23	state	state	NOUN
bam-4803	54	24	.	.	PUNCT
bam-4803	55	1	33	33	NUM
bam-4803	55	2	the	the	DET
bam-4803	55	3	first	first	ADJ
bam-4803	55	4	depictions	depiction	NOUN
bam-4803	55	5	of	of	ADP
bam-4803	55	6	ryr1	ryr1	NOUN
bam-4803	55	7	in	in	ADP
bam-4803	55	8	the	the	DET
bam-4803	55	9	more	more	ADV
bam-4803	55	10	native	native	ADJ
bam-4803	55	11	,	,	PUNCT
bam-4803	55	12	hydrated	hydrated	ADJ
bam-4803	55	13	conditions	condition	NOUN
bam-4803	55	14	came	come	VERB
bam-4803	55	15	~4	~4	NOUN
bam-4803	55	16	years	year	NOUN
bam-4803	55	17	later	later	ADV
bam-4803	55	18	by	by	ADP
bam-4803	55	19	cryo	cryo	PROPN
bam-4803	55	20	-	-	PUNCT
bam-4803	55	21	em	em	PRON
bam-4803	55	22	and	and	CCONJ
bam-4803	55	23	were	be	AUX
bam-4803	55	24	solved	solve	VERB
bam-4803	55	25	to	to	ADP
bam-4803	55	26	~30	~30	X
bam-4803	55	27	å	å	PROPN
bam-4803	55	28	resolution	resolution	NOUN
bam-4803	55	29	.	.	PUNCT
bam-4803	56	1	34,36	34,36	NUM
bam-4803	56	2	low	low	ADJ
bam-4803	56	3	-	-	PUNCT
bam-4803	56	4	resolution	resolution	NOUN
bam-4803	56	5	structural	structural	ADJ
bam-4803	56	6	dynamics	dynamic	NOUN
bam-4803	56	7	of	of	ADP
bam-4803	56	8	ryr1	ryr1	NOUN
bam-4803	56	9	gating	gate	VERB
bam-4803	56	10	were	be	AUX
bam-4803	56	11	described	describe	VERB
bam-4803	56	12	by	by	ADP
bam-4803	56	13	adding	add	VERB
bam-4803	56	14	ligands	ligand	NOUN
bam-4803	56	15	that	that	PRON
bam-4803	56	16	affect	affect	VERB
bam-4803	56	17	channel	channel	NOUN
bam-4803	56	18	open	open	ADJ
bam-4803	56	19	probability	probability	NOUN
bam-4803	56	20	to	to	ADP
bam-4803	56	21	the	the	DET
bam-4803	56	22	cryospecimen	cryospeciman	NOUN
bam-4803	56	23	prior	prior	ADV
bam-4803	56	24	to	to	ADP
bam-4803	56	25	virtification	virtification	NOUN
bam-4803	56	26	.	.	PUNCT
bam-4803	57	1	54,55	54,55	NUM
bam-4803	57	2	several	several	ADJ
bam-4803	57	3	additional	additional	ADJ
bam-4803	57	4	low	low	ADJ
bam-4803	57	5	-	-	PUNCT
bam-4803	57	6	resolution	resolution	NOUN
bam-4803	57	7	structures	structure	NOUN
bam-4803	57	8	of	of	ADP
bam-4803	57	9	ryr1	ryr1	NOUN
bam-4803	57	10	were	be	AUX
bam-4803	57	11	solved	solve	VERB
bam-4803	57	12	that	that	SCONJ
bam-4803	57	13	localized	localize	VERB
bam-4803	57	14	small	small	ADJ
bam-4803	57	15	molecule	molecule	NOUN
bam-4803	57	16	binding	bind	VERB
bam-4803	57	17	sites	site	NOUN
bam-4803	57	18	(	(	PUNCT
bam-4803	57	19	cam	cam	NOUN
bam-4803	57	20	,	,	PUNCT
bam-4803	57	21	fkbp12	fkbp12	NOUN
bam-4803	57	22	and	and	CCONJ
bam-4803	57	23	imperatoxin	imperatoxin	PROPN
bam-4803	57	24	)	)	PUNCT
bam-4803	57	25	and	and	CCONJ
bam-4803	57	26	functional	functional	ADJ
bam-4803	57	27	domains	domain	NOUN
bam-4803	57	28	on	on	ADP
bam-4803	57	29	the	the	DET
bam-4803	57	30	3d	3d	NUM
bam-4803	57	31	structure	structure	NOUN
bam-4803	57	32	of	of	ADP
bam-4803	57	33	ryr1	ryr1	NOUN
bam-4803	57	34	.	.	PUNCT
bam-4803	58	1	46,47,50	46,47,50	NUM
bam-4803	58	2	-	-	SYM
bam-4803	58	3	53	53	NUM
bam-4803	58	4	structures	structure	NOUN
bam-4803	58	5	of	of	ADP
bam-4803	58	6	ryr2	ryr2	NOUN
bam-4803	58	7	and	and	CCONJ
bam-4803	58	8	ryr3	ryr3	PROPN
bam-4803	58	9	isoforms	isoform	NOUN
bam-4803	58	10	were	be	AUX
bam-4803	58	11	also	also	ADV
bam-4803	58	12	determined	determine	VERB
bam-4803	58	13	by	by	ADP
bam-4803	58	14	cryo	cryo	PROPN
bam-4803	58	15	-	-	PUNCT
bam-4803	58	16	em	em	PRON
bam-4803	58	17	and	and	CCONJ
bam-4803	58	18	appear	appear	VERB
bam-4803	58	19	similar	similar	ADJ
bam-4803	58	20	in	in	ADP
bam-4803	58	21	nature	nature	NOUN
bam-4803	58	22	to	to	ADP
bam-4803	58	23	ryr1	ryr1	NOUN
bam-4803	58	24	.	.	PUNCT
bam-4803	59	1	43,45	43,45	NOUN
bam-4803	59	2	in	in	ADP
bam-4803	59	3	two	two	NUM
bam-4803	59	4	decades	decade	NOUN
bam-4803	59	5	since	since	SCONJ
bam-4803	59	6	the	the	DET
bam-4803	59	7	first	first	ADJ
bam-4803	59	8	structure	structure	NOUN
bam-4803	59	9	of	of	ADP
bam-4803	59	10	ryr1	ryr1	NOUN
bam-4803	59	11	by	by	ADP
bam-4803	59	12	cryoem	cryoem	PROPN
bam-4803	59	13	was	be	AUX
bam-4803	59	14	determined	determine	VERB
bam-4803	59	15	,	,	PUNCT
bam-4803	59	16	~1	~1	ADJ
bam-4803	59	17	nm	nm	ADJ
bam-4803	59	18	resolution	resolution	NOUN
bam-4803	59	19	structures	structure	NOUN
bam-4803	59	20	were	be	AUX
bam-4803	59	21	obtained	obtain	VERB
bam-4803	59	22	and	and	CCONJ
bam-4803	59	23	density	density	NOUN
bam-4803	59	24	based	base	VERB
bam-4803	59	25	models	model	NOUN
bam-4803	59	26	of	of	ADP
bam-4803	59	27	channel	channel	NOUN
bam-4803	59	28	gating	gating	NOUN
bam-4803	59	29	were	be	AUX
bam-4803	59	30	proposed	propose	VERB
bam-4803	59	31	.	.	PUNCT
bam-4803	60	1	37,40	37,40	NUM
bam-4803	60	2	homology	homology	NOUN
bam-4803	60	3	models	model	NOUN
bam-4803	60	4	for	for	ADP
bam-4803	60	5	the	the	DET
bam-4803	60	6	n	n	CCONJ
bam-4803	60	7	-	-	PUNCT
bam-4803	60	8	terminal	terminal	ADJ
bam-4803	60	9	domain	domain	NOUN
bam-4803	60	10	of	of	ADP
bam-4803	60	11	the	the	DET
bam-4803	60	12	channel	channel	NOUN
bam-4803	60	13	were	be	AUX
bam-4803	60	14	created	create	VERB
bam-4803	60	15	based	base	VERB
bam-4803	60	16	on	on	ADP
bam-4803	60	17	structures	structure	NOUN
bam-4803	60	18	of	of	ADP
bam-4803	60	19	the	the	DET
bam-4803	60	20	ip	ip	NOUN
bam-4803	60	21	3	3	NUM
bam-4803	60	22	r1	r1	PROPN
bam-4803	60	23	nterminus	nterminus	NOUN
bam-4803	60	24	and	and	CCONJ
bam-4803	60	25	computationally	computationally	ADV
bam-4803	60	26	fitted	fit	VERB
bam-4803	60	27	to	to	ADP
bam-4803	60	28	the	the	DET
bam-4803	60	29	map	map	NOUN
bam-4803	60	30	38,39	38,39	NOUN
bam-4803	60	31	several	several	ADJ
bam-4803	60	32	secondary	secondary	ADJ
bam-4803	60	33	structure	structure	NOUN
bam-4803	60	34	elements	element	NOUN
bam-4803	60	35	in	in	ADP
bam-4803	60	36	the	the	DET
bam-4803	60	37	cytoplasmic	cytoplasmic	ADJ
bam-4803	60	38	and	and	CCONJ
bam-4803	60	39	transmembrane	transmembrane	ADJ
bam-4803	60	40	domains	domain	NOUN
bam-4803	60	41	and	and	CCONJ
bam-4803	60	42	subunit	subunit	NOUN
bam-4803	60	43	boundaries	boundary	NOUN
bam-4803	60	44	were	be	AUX
bam-4803	60	45	detectable	detectable	ADJ
bam-4803	60	46	resulting	result	VERB
bam-4803	60	47	in	in	ADP
bam-4803	60	48	a	a	DET
bam-4803	60	49	molecular	molecular	ADJ
bam-4803	60	50	model	model	NOUN
bam-4803	60	51	for	for	ADP
bam-4803	60	52	some	some	DET
bam-4803	60	53	transmembrane	transmembrane	ADJ
bam-4803	60	54	helices	helix	NOUN
bam-4803	60	55	.	.	PUNCT
bam-4803	61	1	gating	gate	VERB
bam-4803	61	2	induced	induced	ADJ
bam-4803	61	3	structural	structural	ADJ
bam-4803	61	4	changes	change	NOUN
bam-4803	61	5	were	be	AUX
bam-4803	61	6	investigated	investigate	VERB
bam-4803	61	7	in	in	ADP
bam-4803	61	8	a	a	DET
bam-4803	61	9	~1	~1	ADJ
bam-4803	61	10	nm	nm	ADJ
bam-4803	61	11	resolution	resolution	NOUN
bam-4803	61	12	structure	structure	NOUN
bam-4803	61	13	.	.	PUNCT
bam-4803	62	1	41	41	NUM
bam-4803	62	2	structural	structural	ADJ
bam-4803	62	3	models	model	NOUN
bam-4803	62	4	for	for	ADP
bam-4803	62	5	three	three	NUM
bam-4803	62	6	disease	disease	NOUN
bam-4803	62	7	hot	hot	ADJ
bam-4803	62	8	-	-	PUNCT
bam-4803	62	9	spot	spot	NOUN
bam-4803	62	10	domains	domain	NOUN
bam-4803	62	11	were	be	AUX
bam-4803	62	12	determined	determine	VERB
bam-4803	62	13	by	by	ADP
bam-4803	62	14	x	x	NOUN
bam-4803	62	15	-	-	NOUN
bam-4803	62	16	ray	ray	NOUN
bam-4803	62	17	crystallography	crystallography	NOUN
bam-4803	62	18	:	:	PUNCT
bam-4803	62	19	the	the	DET
bam-4803	62	20	ryr1	ryr1	NOUN
bam-4803	62	21	n	n	CCONJ
bam-4803	62	22	-	-	PUNCT
bam-4803	62	23	terminal	terminal	ADJ
bam-4803	62	24	domain	domain	NOUN
bam-4803	62	25	(	(	PUNCT
bam-4803	62	26	residues	residue	NOUN
bam-4803	62	27	1	1	NUM
bam-4803	62	28	-	-	SYM
bam-4803	62	29	559	559	NUM
bam-4803	62	30	;	;	PUNCT
bam-4803	62	31	pdb	pdb	NOUN
bam-4803	62	32	:	:	PUNCT
bam-4803	62	33	2xoa	2xoa	NUM
bam-4803	62	34	)	)	PUNCT
bam-4803	62	35	,	,	PUNCT
bam-4803	62	36	phosphorylation	phosphorylation	NOUN
bam-4803	62	37	domain	domain	NOUN
bam-4803	62	38	(	(	PUNCT
bam-4803	62	39	residues	residue	NOUN
bam-4803	62	40	2734	2734	NUM
bam-4803	62	41	-	-	SYM
bam-4803	62	42	2940	2940	NUM
bam-4803	62	43	;	;	PUNCT
bam-4803	62	44	pdb	pdb	PROPN
bam-4803	62	45	:	:	PUNCT
bam-4803	62	46	4ert	4ert	NUM
bam-4803	62	47	)	)	PUNCT
bam-4803	62	48	and	and	CCONJ
bam-4803	62	49	spry2	spry2	ADJ
bam-4803	62	50	domain	domain	NOUN
bam-4803	62	51	(	(	PUNCT
bam-4803	62	52	residues	residue	NOUN
bam-4803	62	53	1070	1070	NUM
bam-4803	62	54	-	-	SYM
bam-4803	62	55	1246	1246	NUM
bam-4803	62	56	;	;	PUNCT
bam-4803	62	57	pdb	pdb	NOUN
bam-4803	62	58	:	:	PUNCT
bam-4803	62	59	4p9i	4p9i	NOUN
bam-4803	62	60	,	,	PUNCT
bam-4803	62	61	4p9j	4p9j	NOUN
bam-4803	62	62	,	,	PUNCT
bam-4803	62	63	4p9l	4p9l	NOUN
bam-4803	62	64	)	)	PUNCT
bam-4803	62	65	.	.	PUNCT
bam-4803	63	1	59,60,82,98	59,60,82,98	NUM
bam-4803	63	2	with	with	ADP
bam-4803	63	3	state	state	NOUN
bam-4803	63	4	of	of	ADP
bam-4803	63	5	the	the	DET
bam-4803	63	6	art	art	NOUN
bam-4803	63	7	imaging	imaging	NOUN
bam-4803	63	8	technology	technology	NOUN
bam-4803	63	9	in	in	ADP
bam-4803	63	10	place	place	NOUN
bam-4803	63	11	,	,	PUNCT
bam-4803	63	12	the	the	DET
bam-4803	63	13	future	future	NOUN
bam-4803	63	14	for	for	ADP
bam-4803	63	15	the	the	DET
bam-4803	63	16	ca	ca	NOUN
bam-4803	63	17	2	2	NUM
bam-4803	63	18	+	+	NOUN
bam-4803	63	19	release	release	NOUN
bam-4803	63	20	channel	channel	NOUN
bam-4803	63	21	is	be	AUX
bam-4803	63	22	ripe	ripe	ADJ
bam-4803	63	23	to	to	PART
bam-4803	63	24	proceed	proceed	VERB
bam-4803	63	25	towards	towards	ADP
bam-4803	63	26	nearatomic	nearatomic	ADJ
bam-4803	63	27	resolutions	resolution	NOUN
bam-4803	63	28	.	.	PUNCT
bam-4803	64	1	single	single	ADJ
bam-4803	64	2	-	-	PUNCT
bam-4803	64	3	particle	particle	NOUN
bam-4803	64	4	cryo	cryo	NOUN
bam-4803	64	5	-	-	PUNCT
bam-4803	64	6	em	em	PRON
bam-4803	64	7	of	of	ADP
bam-4803	64	8	the	the	DET
bam-4803	64	9	ryanodine	ryanodine	PROPN
bam-4803	64	10	receptor	receptor	NOUN
bam-4803	64	11	channel	channel	PROPN
bam-4803	64	12	eur	eur	PROPN
bam-4803	64	13	j	j	PROPN
bam-4803	64	14	transl	transl	PROPN
bam-4803	64	15	myol	myol	PROPN
bam-4803	64	16	basic	basic	ADJ
bam-4803	64	17	appl	appl	NOUN
bam-4803	64	18	myol	myol	NOUN
bam-4803	64	19	2015	2015	NUM
bam-4803	64	20	;	;	PUNCT
bam-4803	64	21	25	25	NUM
bam-4803	64	22	(	(	PUNCT
bam-4803	64	23	1	1	NUM
bam-4803	64	24	):	):	PUNCT
bam-4803	64	25	35	35	NUM
bam-4803	64	26	-	-	SYM
bam-4803	64	27	48	48	NUM
bam-4803	64	28	38	38	NUM
bam-4803	64	29	spanning	span	VERB
bam-4803	64	30	the	the	DET
bam-4803	64	31	gap	gap	NOUN
bam-4803	64	32	between	between	ADP
bam-4803	64	33	skeletal	skeletal	ADJ
bam-4803	64	34	muscle	muscle	NOUN
bam-4803	64	35	t	t	NOUN
bam-4803	64	36	-	-	PUNCT
bam-4803	64	37	tubule	tubule	NOUN
bam-4803	64	38	and	and	CCONJ
bam-4803	64	39	sr	sr	PROPN
bam-4803	64	40	membranes	membrane	NOUN
bam-4803	64	41	(	(	PUNCT
bam-4803	64	42	fig	fig	NOUN
bam-4803	64	43	.	.	NOUN
bam-4803	64	44	1	1	NUM
bam-4803	64	45	)	)	PUNCT
bam-4803	64	46	.	.	PUNCT
bam-4803	65	1	25	25	NUM
bam-4803	65	2	initially	initially	ADV
bam-4803	65	3	,	,	PUNCT
bam-4803	65	4	the	the	DET
bam-4803	65	5	composition	composition	NOUN
bam-4803	65	6	and	and	CCONJ
bam-4803	65	7	role	role	NOUN
bam-4803	65	8	of	of	ADP
bam-4803	65	9	the	the	DET
bam-4803	65	10	foot	foot	NOUN
bam-4803	65	11	structure	structure	NOUN
bam-4803	65	12	was	be	AUX
bam-4803	65	13	unclear	unclear	ADJ
bam-4803	65	14	until	until	SCONJ
bam-4803	65	15	biochemical	biochemical	ADJ
bam-4803	65	16	isolation	isolation	NOUN
bam-4803	65	17	and	and	CCONJ
bam-4803	65	18	characterization	characterization	NOUN
bam-4803	65	19	led	lead	VERB
bam-4803	65	20	to	to	ADP
bam-4803	65	21	its	its	PRON
bam-4803	65	22	identification	identification	NOUN
bam-4803	65	23	as	as	ADP
bam-4803	65	24	the	the	DET
bam-4803	65	25	ca	ca	NOUN
bam-4803	65	26	2	2	NUM
bam-4803	65	27	+	+	NOUN
bam-4803	65	28	release	release	NOUN
bam-4803	65	29	channel	channel	NOUN
bam-4803	65	30	,	,	PUNCT
bam-4803	65	31	which	which	PRON
bam-4803	65	32	was	be	AUX
bam-4803	65	33	greatly	greatly	ADV
bam-4803	65	34	facilitated	facilitate	VERB
bam-4803	65	35	by	by	ADP
bam-4803	65	36	the	the	DET
bam-4803	65	37	protein	protein	NOUN
bam-4803	65	38	’s	’s	PART
bam-4803	65	39	ability	ability	NOUN
bam-4803	65	40	to	to	PART
bam-4803	65	41	bind	bind	VERB
bam-4803	65	42	the	the	DET
bam-4803	65	43	plant	plant	NOUN
bam-4803	65	44	alkaloid	alkaloid	NOUN
bam-4803	65	45	ryanodine	ryanodine	VERB
bam-4803	65	46	with	with	ADP
bam-4803	65	47	high	high	ADJ
bam-4803	65	48	affinity	affinity	NOUN
bam-4803	65	49	and	and	CCONJ
bam-4803	65	50	specificity	specificity	NOUN
bam-4803	65	51	.	.	PUNCT
bam-4803	66	1	26	26	NUM
bam-4803	66	2	-	-	SYM
bam-4803	66	3	31	31	NUM
bam-4803	66	4	early	early	ADJ
bam-4803	66	5	studies	study	NOUN
bam-4803	66	6	on	on	ADP
bam-4803	66	7	purified	purified	ADJ
bam-4803	66	8	single	single	ADJ
bam-4803	66	9	channels	channel	NOUN
bam-4803	66	10	by	by	ADP
bam-4803	66	11	electron	electron	NOUN
bam-4803	66	12	microscopy	microscopy	NOUN
bam-4803	66	13	provided	provide	VERB
bam-4803	66	14	a	a	DET
bam-4803	66	15	snapshot	snapshot	NOUN
bam-4803	66	16	into	into	ADP
bam-4803	66	17	the	the	DET
bam-4803	66	18	channel	channel	NOUN
bam-4803	66	19	ultrastructure	ultrastructure	NOUN
bam-4803	66	20	and	and	CCONJ
bam-4803	66	21	basic	basic	ADJ
bam-4803	66	22	quaternary	quaternary	ADJ
bam-4803	66	23	features	feature	NOUN
bam-4803	66	24	,	,	PUNCT
bam-4803	66	25	followed	follow	VERB
bam-4803	66	26	by	by	ADP
bam-4803	66	27	the	the	DET
bam-4803	66	28	first	first	ADJ
bam-4803	66	29	3d	3d	NUM
bam-4803	66	30	reconstruction	reconstruction	NOUN
bam-4803	66	31	of	of	ADP
bam-4803	66	32	negatively	negatively	ADV
bam-4803	66	33	stained	stain	VERB
bam-4803	66	34	channel	channel	NOUN
bam-4803	66	35	particles	particle	NOUN
bam-4803	66	36	determined	determine	VERB
bam-4803	66	37	to	to	ADP
bam-4803	66	38	~40	~40	X
bam-4803	66	39	å	å	PRON
bam-4803	66	40	resolution	resolution	NOUN
bam-4803	66	41	.	.	PUNCT
bam-4803	67	1	32,33	32,33	NUM
bam-4803	67	2	these	these	DET
bam-4803	67	3	studies	study	NOUN
bam-4803	67	4	paved	pave	VERB
bam-4803	67	5	the	the	DET
bam-4803	67	6	way	way	NOUN
bam-4803	67	7	for	for	ADP
bam-4803	67	8	determining	determine	VERB
bam-4803	67	9	the	the	DET
bam-4803	67	10	structure	structure	NOUN
bam-4803	67	11	of	of	ADP
bam-4803	67	12	the	the	DET
bam-4803	67	13	detergent	detergent	NOUN
bam-4803	67	14	-	-	PUNCT
bam-4803	67	15	solubilized	solubilize	VERB
bam-4803	67	16	ryr1	ryr1	NOUN
bam-4803	67	17	under	under	ADP
bam-4803	67	18	frozen	frozen	ADJ
bam-4803	67	19	,	,	PUNCT
bam-4803	67	20	hydrated	hydrated	ADJ
bam-4803	67	21	conditions	condition	NOUN
bam-4803	67	22	by	by	ADP
bam-4803	67	23	cryo	cryo	NOUN
bam-4803	67	24	-	-	PUNCT
bam-4803	67	25	em	em	PROPN
bam-4803	67	26	.	.	PUNCT
bam-4803	67	27	extensive	extensive	ADJ
bam-4803	67	28	efforts	effort	NOUN
bam-4803	67	29	have	have	AUX
bam-4803	67	30	been	be	AUX
bam-4803	67	31	made	make	VERB
bam-4803	67	32	to	to	PART
bam-4803	67	33	study	study	VERB
bam-4803	67	34	the	the	DET
bam-4803	67	35	3d	3d	NUM
bam-4803	67	36	structure	structure	NOUN
bam-4803	67	37	of	of	ADP
bam-4803	67	38	the	the	DET
bam-4803	67	39	detergent	detergent	NOUN
bam-4803	67	40	-	-	PUNCT
bam-4803	67	41	solubilized	solubilize	VERB
bam-4803	67	42	ryr1	ryr1	NOUN
bam-4803	67	43	by	by	ADP
bam-4803	67	44	using	use	VERB
bam-4803	67	45	electron	electron	NOUN
bam-4803	67	46	microscopy	microscopy	NOUN
bam-4803	67	47	of	of	ADP
bam-4803	67	48	both	both	DET
bam-4803	67	49	single	single	ADJ
bam-4803	67	50	particles	particle	NOUN
bam-4803	67	51	34	34	NUM
bam-4803	67	52	-	-	SYM
bam-4803	67	53	41	41	NUM
bam-4803	67	54	and	and	CCONJ
bam-4803	67	55	2d	2d	NUM
bam-4803	67	56	crystals	crystal	NOUN
bam-4803	67	57	.	.	PUNCT
bam-4803	68	1	42	42	NUM
bam-4803	68	2	the	the	DET
bam-4803	68	3	first	first	ADJ
bam-4803	68	4	structures	structure	NOUN
bam-4803	68	5	of	of	ADP
bam-4803	68	6	ryr1	ryr1	NOUN
bam-4803	68	7	by	by	ADP
bam-4803	68	8	single	single	ADJ
bam-4803	68	9	-	-	PUNCT
bam-4803	68	10	particle	particle	NOUN
bam-4803	68	11	cryoem	cryoem	NOUN
bam-4803	68	12	were	be	AUX
bam-4803	68	13	generated	generate	VERB
bam-4803	68	14	for	for	ADP
bam-4803	68	15	the	the	DET
bam-4803	68	16	‘	'	PUNCT
bam-4803	68	17	closed	closed	ADJ
bam-4803	68	18	’	'	PUNCT
bam-4803	68	19	ca	can	AUX
bam-4803	68	20	2+depleted	2+deplete	VERB
bam-4803	68	21	state	state	NOUN
bam-4803	68	22	by	by	ADP
bam-4803	68	23	two	two	NUM
bam-4803	68	24	different	different	ADJ
bam-4803	68	25	groups	group	NOUN
bam-4803	68	26	to	to	ADP
bam-4803	68	27	~40	~40	NOUN
bam-4803	68	28	å	å	PRON
bam-4803	68	29	resolution	resolution	NOUN
bam-4803	68	30	elucidating	elucidate	VERB
bam-4803	68	31	its	its	PRON
bam-4803	68	32	now	now	ADV
bam-4803	68	33	characteristic	characteristic	ADJ
bam-4803	68	34	mushroom	mushroom	NOUN
bam-4803	68	35	-	-	PUNCT
bam-4803	68	36	shape	shape	NOUN
bam-4803	68	37	appearance	appearance	NOUN
bam-4803	68	38	34,36	34,36	NUM
bam-4803	68	39	the	the	DET
bam-4803	68	40	general	general	ADJ
bam-4803	68	41	structure	structure	NOUN
bam-4803	68	42	of	of	ADP
bam-4803	68	43	the	the	DET
bam-4803	68	44	ryr1	ryr1	NOUN
bam-4803	68	45	channel	channel	NOUN
bam-4803	68	46	exhibits	exhibit	VERB
bam-4803	68	47	4fold	4fold	NUM
bam-4803	68	48	symmetry	symmetry	NOUN
bam-4803	68	49	with	with	ADP
bam-4803	68	50	an	an	DET
bam-4803	68	51	overall	overall	ADJ
bam-4803	68	52	square	square	ADJ
bam-4803	68	53	-	-	PUNCT
bam-4803	68	54	mushroom	mushroom	NOUN
bam-4803	68	55	shape	shape	NOUN
bam-4803	68	56	top	top	NOUN
bam-4803	68	57	(	(	PUNCT
bam-4803	68	58	280	280	NUM
bam-4803	68	59	å	å	PROPN
bam-4803	68	60	×	×	NOUN
bam-4803	68	61	280	280	NUM
bam-4803	68	62	å	å	PROPN
bam-4803	68	63	×	×	NOUN
bam-4803	68	64	120	120	NUM
bam-4803	68	65	å	å	NOUN
bam-4803	68	66	)	)	PUNCT
bam-4803	68	67	connected	connect	VERB
bam-4803	68	68	to	to	ADP
bam-4803	68	69	a	a	DET
bam-4803	68	70	stalk	stalk	NOUN
bam-4803	68	71	structure	structure	NOUN
bam-4803	68	72	(	(	PUNCT
bam-4803	68	73	120	120	NUM
bam-4803	68	74	å	å	PROPN
bam-4803	68	75	×	×	NOUN
bam-4803	68	76	120	120	NUM
bam-4803	68	77	å	å	PROPN
bam-4803	68	78	×	×	NOUN
bam-4803	68	79	60	60	NUM
bam-4803	68	80	å	å	NOUN
bam-4803	68	81	)	)	PUNCT
bam-4803	68	82	(	(	PUNCT
bam-4803	68	83	fig	fig	NOUN
bam-4803	68	84	2	2	NUM
bam-4803	68	85	)	)	PUNCT
bam-4803	68	86	.	.	PUNCT
bam-4803	69	1	much	much	ADJ
bam-4803	69	2	of	of	ADP
bam-4803	69	3	ryr1	ryr1	PROPN
bam-4803	69	4	’s	’s	PART
bam-4803	69	5	mass	mass	NOUN
bam-4803	69	6	is	be	AUX
bam-4803	69	7	contained	contain	VERB
bam-4803	69	8	in	in	ADP
bam-4803	69	9	the	the	DET
bam-4803	69	10	cytoplasmic	cytoplasmic	ADJ
bam-4803	69	11	domain	domain	NOUN
bam-4803	69	12	and	and	CCONJ
bam-4803	69	13	is	be	AUX
bam-4803	69	14	connected	connect	VERB
bam-4803	69	15	to	to	ADP
bam-4803	69	16	the	the	DET
bam-4803	69	17	transmembrane	transmembrane	NOUN
bam-4803	69	18	domain	domain	NOUN
bam-4803	69	19	through	through	ADP
bam-4803	69	20	the	the	DET
bam-4803	69	21	stalk	stalk	NOUN
bam-4803	69	22	structure	structure	NOUN
bam-4803	69	23	that	that	PRON
bam-4803	69	24	is	be	AUX
bam-4803	69	25	composed	compose	VERB
bam-4803	69	26	of	of	ADP
bam-4803	69	27	four	four	NUM
bam-4803	69	28	column	column	NOUN
bam-4803	69	29	domains	domain	NOUN
bam-4803	69	30	and	and	CCONJ
bam-4803	69	31	rotated	rotate	VERB
bam-4803	69	32	~40	~40	ADV
bam-4803	69	33	°	°	NOUN
bam-4803	69	34	with	with	ADP
bam-4803	69	35	respect	respect	NOUN
bam-4803	69	36	to	to	ADP
bam-4803	69	37	the	the	DET
bam-4803	69	38	cytoplasmic	cytoplasmic	ADJ
bam-4803	69	39	domain	domain	NOUN
bam-4803	69	40	.	.	PUNCT
bam-4803	70	1	the	the	DET
bam-4803	70	2	cytoplasmic	cytoplasmic	ADJ
bam-4803	70	3	region	region	NOUN
bam-4803	70	4	contains	contain	VERB
bam-4803	70	5	several	several	ADJ
bam-4803	70	6	cavities	cavity	NOUN
bam-4803	70	7	and	and	CCONJ
bam-4803	70	8	globular	globular	ADJ
bam-4803	70	9	sub	sub	NOUN
bam-4803	70	10	-	-	NOUN
bam-4803	70	11	regions	region	NOUN
bam-4803	70	12	with	with	ADP
bam-4803	70	13	highly	highly	ADV
bam-4803	70	14	flexible	flexible	ADJ
bam-4803	70	15	clamp	clamp	NOUN
bam-4803	70	16	-	-	PUNCT
bam-4803	70	17	shaped	shape	VERB
bam-4803	70	18	structures	structure	NOUN
bam-4803	70	19	present	present	ADJ
bam-4803	70	20	at	at	ADP
bam-4803	70	21	the	the	DET
bam-4803	70	22	corners	corner	NOUN
bam-4803	70	23	.	.	PUNCT
bam-4803	71	1	structures	structure	NOUN
bam-4803	71	2	of	of	ADP
bam-4803	71	3	the	the	DET
bam-4803	71	4	ryr2	ryr2	NOUN
bam-4803	71	5	and	and	CCONJ
bam-4803	71	6	ryr3	ryr3	PROPN
bam-4803	71	7	isoforms	isoform	NOUN
bam-4803	71	8	determined	determine	VERB
bam-4803	71	9	by	by	ADP
bam-4803	71	10	cryo	cryo	PROPN
bam-4803	71	11	-	-	PUNCT
bam-4803	71	12	em	em	PRON
bam-4803	71	13	have	have	VERB
bam-4803	71	14	an	an	DET
bam-4803	71	15	overall	overall	ADJ
bam-4803	71	16	architecture	architecture	NOUN
bam-4803	71	17	similar	similar	ADJ
bam-4803	71	18	to	to	ADP
bam-4803	71	19	that	that	PRON
bam-4803	71	20	of	of	ADP
bam-4803	71	21	the	the	DET
bam-4803	71	22	ryr1	ryr1	PROPN
bam-4803	71	23	channel	channel	PROPN
bam-4803	71	24	.	.	PUNCT
bam-4803	72	1	43	43	NUM
bam-4803	72	2	-	-	SYM
bam-4803	72	3	49	49	NUM
bam-4803	72	4	the	the	DET
bam-4803	72	5	cytoplasmic	cytoplasmic	ADJ
bam-4803	72	6	portion	portion	NOUN
bam-4803	72	7	of	of	ADP
bam-4803	72	8	ryr1	ryr1	NOUN
bam-4803	72	9	serves	serve	VERB
bam-4803	72	10	as	as	ADP
bam-4803	72	11	a	a	DET
bam-4803	72	12	scaffold	scaffold	NOUN
bam-4803	72	13	for	for	ADP
bam-4803	72	14	many	many	ADJ
bam-4803	72	15	of	of	ADP
bam-4803	72	16	the	the	DET
bam-4803	72	17	channel	channel	NOUN
bam-4803	72	18	regulators	regulator	NOUN
bam-4803	72	19	.	.	PUNCT
bam-4803	73	1	several	several	ADJ
bam-4803	73	2	domains	domain	NOUN
bam-4803	73	3	46,47,50	46,47,50	NUM
bam-4803	73	4	and	and	CCONJ
bam-4803	73	5	modulator	modulator	NOUN
bam-4803	73	6	binding	bind	VERB
bam-4803	73	7	sites	site	NOUN
bam-4803	73	8	(	(	PUNCT
bam-4803	73	9	e.g.	e.g.	ADV
bam-4803	73	10	fkbp12	fkbp12	NOUN
bam-4803	73	11	,	,	PUNCT
bam-4803	73	12	calmodulin	calmodulin	PROPN
bam-4803	73	13	,	,	PUNCT
bam-4803	73	14	imperatoxin	imperatoxin	PRON
bam-4803	73	15	a	a	PRON
bam-4803	73	16	have	have	AUX
bam-4803	73	17	been	be	AUX
bam-4803	73	18	mapped	map	VERB
bam-4803	73	19	to	to	ADP
bam-4803	73	20	the	the	DET
bam-4803	73	21	3d	3d	NUM
bam-4803	73	22	structure	structure	NOUN
bam-4803	73	23	of	of	ADP
bam-4803	73	24	the	the	DET
bam-4803	73	25	channel	channel	NOUN
bam-4803	73	26	.	.	PUNCT
bam-4803	74	1	5153	5153	NUM
bam-4803	74	2	while	while	SCONJ
bam-4803	74	3	these	these	DET
bam-4803	74	4	structures	structure	NOUN
bam-4803	74	5	were	be	AUX
bam-4803	74	6	determined	determine	VERB
bam-4803	74	7	at	at	ADP
bam-4803	74	8	low	low	ADJ
bam-4803	74	9	resolutions	resolution	NOUN
bam-4803	74	10	,	,	PUNCT
bam-4803	74	11	they	they	PRON
bam-4803	74	12	have	have	AUX
bam-4803	74	13	provided	provide	VERB
bam-4803	74	14	an	an	DET
bam-4803	74	15	abundance	abundance	NOUN
bam-4803	74	16	of	of	ADP
bam-4803	74	17	information	information	NOUN
bam-4803	74	18	concerning	concern	VERB
bam-4803	74	19	the	the	DET
bam-4803	74	20	regulation	regulation	NOUN
bam-4803	74	21	of	of	ADP
bam-4803	74	22	the	the	DET
bam-4803	74	23	channel	channel	NOUN
bam-4803	74	24	.	.	PUNCT
bam-4803	75	1	moreover	moreover	ADV
bam-4803	75	2	,	,	PUNCT
bam-4803	75	3	in	in	ADP
bam-4803	75	4	cases	case	NOUN
bam-4803	75	5	where	where	SCONJ
bam-4803	75	6	the	the	DET
bam-4803	75	7	binding	bind	VERB
bam-4803	75	8	/	/	SYM
bam-4803	75	9	regulatory	regulatory	ADJ
bam-4803	75	10	sequences	sequence	NOUN
bam-4803	75	11	are	be	AUX
bam-4803	75	12	known	know	VERB
bam-4803	75	13	,	,	PUNCT
bam-4803	75	14	localization	localization	NOUN
bam-4803	75	15	allows	allow	VERB
bam-4803	75	16	for	for	ADP
bam-4803	75	17	the	the	DET
bam-4803	75	18	assignment	assignment	NOUN
bam-4803	75	19	of	of	ADP
bam-4803	75	20	sequence	sequence	NOUN
bam-4803	75	21	to	to	ADP
bam-4803	75	22	the	the	DET
bam-4803	75	23	3d	3d	NUM
bam-4803	75	24	structure	structure	NOUN
bam-4803	75	25	.	.	PUNCT
bam-4803	76	1	conformational	conformational	ADJ
bam-4803	76	2	changes	change	NOUN
bam-4803	76	3	associated	associate	VERB
bam-4803	76	4	with	with	ADP
bam-4803	76	5	ryr1	ryr1	PROPN
bam-4803	76	6	channel	channel	NOUN
bam-4803	76	7	opening	opening	NOUN
bam-4803	76	8	were	be	AUX
bam-4803	76	9	also	also	ADV
bam-4803	76	10	addressed	address	VERB
bam-4803	76	11	by	by	ADP
bam-4803	76	12	cryo	cryo	PROPN
bam-4803	76	13	-	-	PUNCT
bam-4803	76	14	em	em	PROPN
bam-4803	76	15	.	.	PROPN
bam-4803	76	16	based	base	VERB
bam-4803	76	17	on	on	ADP
bam-4803	76	18	biochemical	biochemical	ADJ
bam-4803	76	19	and	and	CCONJ
bam-4803	76	20	electrophysiological	electrophysiological	ADJ
bam-4803	76	21	studies	study	NOUN
bam-4803	76	22	,	,	PUNCT
bam-4803	76	23	ryr	ryr	NOUN
bam-4803	76	24	channel	channel	NOUN
bam-4803	76	25	gating	gating	NOUN
bam-4803	76	26	can	can	AUX
bam-4803	76	27	be	be	AUX
bam-4803	76	28	controlled	control	VERB
bam-4803	76	29	by	by	ADP
bam-4803	76	30	the	the	DET
bam-4803	76	31	presence	presence	NOUN
bam-4803	76	32	of	of	ADP
bam-4803	76	33	ca	ca	NOUN
bam-4803	76	34	2	2	NUM
bam-4803	76	35	+	+	CCONJ
bam-4803	76	36	,	,	PUNCT
bam-4803	76	37	adenine	adenine	VERB
bam-4803	76	38	nucleotides	nucleotide	NOUN
bam-4803	76	39	and	and	CCONJ
bam-4803	76	40	ryanodine	ryanodine	NOUN
bam-4803	76	41	.	.	PUNCT
bam-4803	77	1	the	the	DET
bam-4803	77	2	addition	addition	NOUN
bam-4803	77	3	of	of	ADP
bam-4803	77	4	channel	channel	NOUN
bam-4803	77	5	activators	activator	NOUN
bam-4803	77	6	to	to	ADP
bam-4803	77	7	the	the	DET
bam-4803	77	8	ryr1	ryr1	NOUN
bam-4803	77	9	cryospecimen	cryospeciman	NOUN
bam-4803	77	10	permitted	permit	VERB
bam-4803	77	11	samples	sample	NOUN
bam-4803	77	12	to	to	PART
bam-4803	77	13	be	be	AUX
bam-4803	77	14	driven	drive	VERB
bam-4803	77	15	into	into	ADP
bam-4803	77	16	a	a	DET
bam-4803	77	17	channel	channel	NOUN
bam-4803	77	18	‘	'	PUNCT
bam-4803	77	19	open	open	ADJ
bam-4803	77	20	’	'	PUNCT
bam-4803	77	21	state	state	NOUN
bam-4803	77	22	,	,	PUNCT
bam-4803	77	23	allowing	allow	VERB
bam-4803	77	24	for	for	ADP
bam-4803	77	25	the	the	DET
bam-4803	77	26	investigation	investigation	NOUN
bam-4803	77	27	of	of	ADP
bam-4803	77	28	the	the	DET
bam-4803	77	29	molecular	molecular	ADJ
bam-4803	77	30	motions	motion	NOUN
bam-4803	77	31	associated	associate	VERB
bam-4803	77	32	with	with	ADP
bam-4803	77	33	several	several	ADJ
bam-4803	77	34	states	state	NOUN
bam-4803	77	35	of	of	ADP
bam-4803	77	36	channel	channel	NOUN
bam-4803	77	37	gating	gating	NOUN
bam-4803	77	38	.	.	PUNCT
bam-4803	78	1	54,55	54,55	CCONJ
bam-4803	78	2	these	these	DET
bam-4803	78	3	studies	study	NOUN
bam-4803	78	4	detailed	detail	VERB
bam-4803	78	5	the	the	DET
bam-4803	78	6	first	first	ADJ
bam-4803	78	7	direct	direct	ADJ
bam-4803	78	8	evidence	evidence	NOUN
bam-4803	78	9	of	of	ADP
bam-4803	78	10	the	the	DET
bam-4803	78	11	channel	channel	NOUN
bam-4803	78	12	’s	’s	PART
bam-4803	78	13	long	long	ADJ
bam-4803	78	14	-	-	PUNCT
bam-4803	78	15	range	range	NOUN
bam-4803	78	16	structural	structural	ADJ
bam-4803	78	17	changes	change	NOUN
bam-4803	78	18	under	under	ADP
bam-4803	78	19	activating	activate	VERB
bam-4803	78	20	conditions	condition	NOUN
bam-4803	78	21	revealing	reveal	VERB
bam-4803	78	22	general	general	ADJ
bam-4803	78	23	allosteric	allosteric	ADJ
bam-4803	78	24	mass	mass	NOUN
bam-4803	78	25	rearrangements	rearrangement	NOUN
bam-4803	78	26	that	that	PRON
bam-4803	78	27	occur	occur	VERB
bam-4803	78	28	with	with	ADP
bam-4803	78	29	channel	channel	NOUN
bam-4803	78	30	gating	gating	NOUN
bam-4803	78	31	.	.	PUNCT
bam-4803	79	1	at	at	ADP
bam-4803	79	2	~30	~30	X
bam-4803	79	3	å	å	X
bam-4803	79	4	resolution	resolution	NOUN
bam-4803	79	5	the	the	DET
bam-4803	79	6	ryr1	ryr1	NOUN
bam-4803	79	7	structure	structure	NOUN
bam-4803	79	8	exhibited	exhibit	VERB
bam-4803	79	9	a	a	DET
bam-4803	79	10	global	global	ADJ
bam-4803	79	11	conformational	conformational	ADJ
bam-4803	79	12	change	change	NOUN
bam-4803	79	13	,	,	PUNCT
bam-4803	79	14	opening	opening	NOUN
bam-4803	79	15	of	of	ADP
bam-4803	79	16	the	the	DET
bam-4803	79	17	cytoplasmic	cytoplasmic	ADJ
bam-4803	79	18	clamp	clamp	NOUN
bam-4803	79	19	domains	domain	NOUN
bam-4803	79	20	,	,	PUNCT
bam-4803	79	21	mass	mass	ADJ
bam-4803	79	22	depletion	depletion	NOUN
bam-4803	79	23	and	and	CCONJ
bam-4803	79	24	a	a	DET
bam-4803	79	25	4	4	NUM
bam-4803	79	26	twist	twist	NOUN
bam-4803	79	27	of	of	ADP
bam-4803	79	28	the	the	DET
bam-4803	79	29	transmembrane	transmembrane	NOUN
bam-4803	79	30	domain	domain	NOUN
bam-4803	79	31	,	,	PUNCT
bam-4803	79	32	twisting	twist	VERB
bam-4803	79	33	like	like	ADP
bam-4803	79	34	the	the	DET
bam-4803	79	35	iris	iris	NOUN
bam-4803	79	36	of	of	ADP
bam-4803	79	37	a	a	DET
bam-4803	79	38	camera	camera	NOUN
bam-4803	79	39	.	.	PUNCT
bam-4803	80	1	54,55	54,55	CCONJ
bam-4803	80	2	our	our	PRON
bam-4803	80	3	current	current	ADJ
bam-4803	80	4	knowledge	knowledge	NOUN
bam-4803	80	5	of	of	ADP
bam-4803	80	6	ryr1	ryr1	NOUN
bam-4803	80	7	’s	’s	PART
bam-4803	80	8	structure	structure	NOUN
bam-4803	80	9	has	have	AUX
bam-4803	80	10	progressed	progress	VERB
bam-4803	80	11	from	from	ADP
bam-4803	80	12	a	a	DET
bam-4803	80	13	rather	rather	ADV
bam-4803	80	14	hollow	hollow	ADJ
bam-4803	80	15	appearing	appearing	ADJ
bam-4803	80	16	cytoplasmic	cytoplasmic	ADJ
bam-4803	80	17	domain	domain	NOUN
bam-4803	80	18	nested	nest	VERB
bam-4803	80	19	atop	atop	ADP
bam-4803	80	20	a	a	DET
bam-4803	80	21	dense	dense	ADJ
bam-4803	80	22	stalk	stalk	NOUN
bam-4803	80	23	containing	contain	VERB
bam-4803	80	24	the	the	DET
bam-4803	80	25	transmembrane	transmembrane	ADJ
bam-4803	80	26	domain	domain	NOUN
bam-4803	80	27	to	to	PART
bam-4803	80	28	moderately	moderately	ADV
bam-4803	80	29	high	high	ADJ
bam-4803	80	30	resolution	resolution	NOUN
bam-4803	80	31	structures	structure	NOUN
bam-4803	80	32	where	where	SCONJ
bam-4803	80	33	some	some	DET
bam-4803	80	34	secondary	secondary	ADJ
bam-4803	80	35	structure	structure	NOUN
bam-4803	80	36	features	feature	NOUN
bam-4803	80	37	are	be	AUX
bam-4803	80	38	detectable	detectable	ADJ
bam-4803	80	39	,	,	PUNCT
bam-4803	80	40	domain	domain	NOUN
bam-4803	80	41	and	and	CCONJ
bam-4803	80	42	subunit	subunit	NOUN
bam-4803	80	43	boundaries	boundary	NOUN
bam-4803	80	44	are	be	AUX
bam-4803	80	45	more	more	ADV
bam-4803	80	46	clearly	clearly	ADV
bam-4803	80	47	distinguishable	distinguishable	ADJ
bam-4803	80	48	and	and	CCONJ
bam-4803	80	49	a	a	DET
bam-4803	80	50	putative	putative	ADJ
bam-4803	80	51	pore	pore	ADJ
bam-4803	80	52	region	region	NOUN
bam-4803	80	53	is	be	AUX
bam-4803	80	54	described	describe	VERB
bam-4803	80	55	.	.	PUNCT
bam-4803	81	1	from	from	ADP
bam-4803	81	2	the	the	DET
bam-4803	81	3	initial	initial	ADJ
bam-4803	81	4	data	datum	NOUN
bam-4803	81	5	set	set	VERB
bam-4803	81	6	by	by	ADP
bam-4803	81	7	serysheva	serysheva	PROPN
bam-4803	81	8	et	et	PROPN
bam-4803	81	9	al	al	PROPN
bam-4803	81	10	.	.	PROPN
bam-4803	81	11	36	36	NUM
bam-4803	81	12	algorithmic	algorithmic	ADJ
bam-4803	81	13	improvements	improvement	NOUN
bam-4803	81	14	in	in	ADP
bam-4803	81	15	image	image	NOUN
bam-4803	81	16	processing	processing	NOUN
bam-4803	81	17	correcting	correct	VERB
bam-4803	81	18	for	for	ADP
bam-4803	81	19	microscope	microscope	NOUN
bam-4803	81	20	aberrations	aberration	NOUN
bam-4803	81	21	using	use	VERB
bam-4803	81	22	ctf	ctf	ADJ
bam-4803	81	23	correction	correction	NOUN
bam-4803	81	24	resulted	result	VERB
bam-4803	81	25	in	in	ADP
bam-4803	81	26	a	a	DET
bam-4803	81	27	14	14	NUM
bam-4803	81	28	å	å	NOUN
bam-4803	81	29	resolution	resolution	NOUN
bam-4803	81	30	map	map	NOUN
bam-4803	81	31	of	of	ADP
bam-4803	81	32	ryr1	ryr1	NOUN
bam-4803	81	33	38	38	NUM
bam-4803	81	34	(	(	PUNCT
bam-4803	81	35	fig	fig	NOUN
bam-4803	81	36	.	.	PUNCT
bam-4803	82	1	2	2	NUM
bam-4803	82	2	,	,	PUNCT
bam-4803	82	3	left	leave	VERB
bam-4803	82	4	)	)	PUNCT
bam-4803	82	5	.	.	PUNCT
bam-4803	83	1	the	the	DET
bam-4803	83	2	improved	improve	VERB
bam-4803	83	3	map	map	NOUN
bam-4803	83	4	exhibited	exhibit	VERB
bam-4803	83	5	more	more	ADJ
bam-4803	83	6	structural	structural	ADJ
bam-4803	83	7	detail	detail	NOUN
bam-4803	83	8	and	and	CCONJ
bam-4803	83	9	allowed	allow	VERB
bam-4803	83	10	for	for	ADP
bam-4803	83	11	generation	generation	NOUN
bam-4803	83	12	and	and	CCONJ
bam-4803	83	13	fitting	fitting	NOUN
bam-4803	83	14	of	of	ADP
bam-4803	83	15	a	a	DET
bam-4803	83	16	homologous	homologous	ADJ
bam-4803	83	17	structural	structural	ADJ
bam-4803	83	18	model	model	NOUN
bam-4803	83	19	for	for	ADP
bam-4803	83	20	the	the	DET
bam-4803	83	21	ryr1	ryr1	NOUN
bam-4803	83	22	nterminal	nterminal	ADJ
bam-4803	83	23	domain	domain	NOUN
bam-4803	83	24	(	(	PUNCT
bam-4803	83	25	residues	residue	NOUN
bam-4803	83	26	216	216	NUM
bam-4803	83	27	-	-	SYM
bam-4803	83	28	572	572	NUM
bam-4803	83	29	)	)	PUNCT
bam-4803	83	30	within	within	ADP
bam-4803	83	31	the	the	DET
bam-4803	83	32	clamp	clamp	NOUN
bam-4803	83	33	region	region	NOUN
bam-4803	83	34	.	.	PUNCT
bam-4803	84	1	the	the	DET
bam-4803	84	2	arrangement	arrangement	NOUN
bam-4803	84	3	of	of	ADP
bam-4803	84	4	-helices	-helices	PROPN
bam-4803	84	5	in	in	ADP
bam-4803	84	6	the	the	DET
bam-4803	84	7	transmembrane	transmembrane	NOUN
bam-4803	84	8	domain	domain	NOUN
bam-4803	84	9	were	be	AUX
bam-4803	84	10	still	still	ADV
bam-4803	84	11	ambiguous	ambiguous	ADJ
bam-4803	84	12	in	in	ADP
bam-4803	84	13	the	the	DET
bam-4803	84	14	14	14	NUM
bam-4803	84	15	å	å	PROPN
bam-4803	84	16	resolution	resolution	NOUN
bam-4803	84	17	density	density	NOUN
bam-4803	84	18	map	map	NOUN
bam-4803	84	19	of	of	ADP
bam-4803	84	20	ryr1	ryr1	NOUN
bam-4803	84	21	,	,	PUNCT
bam-4803	84	22	however	however	ADV
bam-4803	84	23	,	,	PUNCT
bam-4803	84	24	two	two	NUM
bam-4803	84	25	groups	group	NOUN
bam-4803	84	26	achieving	achieve	VERB
bam-4803	84	27	10.2	10.2	NUM
bam-4803	84	28	å	å	NOUN
bam-4803	84	29	and	and	CCONJ
bam-4803	84	30	9.6	9.6	NUM
bam-4803	84	31	å	å	NOUN
bam-4803	84	32	resolution	resolution	NOUN
bam-4803	84	33	structures	structure	NOUN
bam-4803	84	34	(	(	PUNCT
bam-4803	84	35	fig	fig	NOUN
bam-4803	84	36	.	.	PUNCT
bam-4803	85	1	2	2	NUM
bam-4803	85	2	,	,	PUNCT
bam-4803	85	3	middle	middle	ADJ
bam-4803	85	4	and	and	CCONJ
bam-4803	85	5	right	right	ADJ
bam-4803	85	6	)	)	PUNCT
bam-4803	85	7	of	of	ADP
bam-4803	85	8	the	the	DET
bam-4803	85	9	ca	ca	NOUN
bam-4803	85	10	2	2	NUM
bam-4803	85	11	+	+	CCONJ
bam-4803	85	12	-depleted	-depleted	ADJ
bam-4803	85	13	state	state	NOUN
bam-4803	85	14	of	of	ADP
bam-4803	85	15	ryr1	ryr1	NOUN
bam-4803	85	16	resolved	resolve	VERB
bam-4803	85	17	5	5	NUM
bam-4803	85	18	-	-	SYM
bam-4803	85	19	6	6	NUM
bam-4803	85	20	-helices	-helices	PROPN
bam-4803	85	21	in	in	ADP
bam-4803	85	22	the	the	DET
bam-4803	85	23	transmembrane	transmembrane	NOUN
bam-4803	85	24	and	and	CCONJ
bam-4803	85	25	pore	pore	ADJ
bam-4803	85	26	domains	domain	NOUN
bam-4803	85	27	,	,	PUNCT
bam-4803	85	28	fig	fig	NOUN
bam-4803	85	29	2	2	NUM
bam-4803	85	30	.	.	PUNCT
bam-4803	85	31	3d	3d	NUM
bam-4803	85	32	structures	structure	NOUN
bam-4803	85	33	of	of	ADP
bam-4803	85	34	the	the	DET
bam-4803	85	35	tetrameric	tetrameric	ADJ
bam-4803	85	36	ryr1	ryr1	NOUN
bam-4803	85	37	channel	channel	NOUN
bam-4803	85	38	determined	determine	VERB
bam-4803	85	39	by	by	ADP
bam-4803	85	40	cryo	cryo	PROPN
bam-4803	85	41	-	-	PUNCT
bam-4803	85	42	em	em	PROPN
bam-4803	85	43	.	.	PUNCT
bam-4803	85	44	surface	surface	NOUN
bam-4803	85	45	representations	representation	NOUN
bam-4803	85	46	of	of	ADP
bam-4803	85	47	ryr1	ryr1	NOUN
bam-4803	85	48	density	density	NOUN
bam-4803	85	49	maps	map	NOUN
bam-4803	85	50	by	by	ADP
bam-4803	85	51	single	single	ADJ
bam-4803	85	52	-	-	PUNCT
bam-4803	85	53	particle	particle	NOUN
bam-4803	85	54	cryo	cryo	NOUN
bam-4803	85	55	-	-	PUNCT
bam-4803	85	56	em	em	PRON
bam-4803	85	57	viewed	view	VERB
bam-4803	85	58	in	in	ADP
bam-4803	85	59	three	three	NUM
bam-4803	85	60	orthogonal	orthogonal	ADJ
bam-4803	85	61	views	view	NOUN
bam-4803	85	62	–	–	PUNCT
bam-4803	85	63	from	from	ADP
bam-4803	85	64	cytoplasm	cytoplasm	ADJ
bam-4803	85	65	(	(	PUNCT
bam-4803	85	66	top	top	NOUN
bam-4803	85	67	)	)	PUNCT
bam-4803	85	68	,	,	PUNCT
bam-4803	85	69	along	along	ADP
bam-4803	85	70	the	the	DET
bam-4803	85	71	membrane	membrane	NOUN
bam-4803	85	72	plane	plane	NOUN
bam-4803	85	73	(	(	PUNCT
bam-4803	85	74	middle	middle	ADJ
bam-4803	85	75	)	)	PUNCT
bam-4803	85	76	and	and	CCONJ
bam-4803	85	77	from	from	ADP
bam-4803	85	78	luminal	luminal	ADJ
bam-4803	85	79	side	side	NOUN
bam-4803	85	80	(	(	PUNCT
bam-4803	85	81	bottom	bottom	NOUN
bam-4803	85	82	)	)	PUNCT
bam-4803	85	83	of	of	ADP
bam-4803	85	84	the	the	DET
bam-4803	85	85	membrane	membrane	NOUN
bam-4803	85	86	.	.	PUNCT
bam-4803	86	1	left	leave	VERB
bam-4803	86	2	to	to	ADP
bam-4803	86	3	right	right	NOUN
bam-4803	86	4	are	be	AUX
bam-4803	86	5	ryr1	ryr1	NOUN
bam-4803	86	6	density	density	NOUN
bam-4803	86	7	maps	map	NOUN
bam-4803	86	8	at	at	ADP
bam-4803	86	9	14	14	NUM
bam-4803	86	10	å	å	PROPN
bam-4803	86	11	(	(	PUNCT
bam-4803	86	12	emd-1274	emd-1274	NOUN
bam-4803	86	13	)	)	PUNCT
bam-4803	86	14	,	,	PUNCT
bam-4803	87	1	10.2	10.2	NUM
bam-4803	87	2	å	å	PROPN
bam-4803	87	3	(	(	PUNCT
bam-4803	87	4	emd-5014	emd-5014	NOUN
bam-4803	87	5	)	)	PUNCT
bam-4803	87	6	and	and	CCONJ
bam-4803	87	7	9.6	9.6	NUM
bam-4803	87	8	å	å	NOUN
bam-4803	87	9	(	(	PUNCT
bam-4803	87	10	emd-1275	emd-1275	NOUN
bam-4803	87	11	)	)	PUNCT
bam-4803	87	12	resolutions	resolution	NOUN
bam-4803	87	13	.	.	PUNCT
bam-4803	88	1	37,38,40	37,38,40	NUM
bam-4803	88	2	single	single	ADJ
bam-4803	88	3	-	-	PUNCT
bam-4803	88	4	particle	particle	NOUN
bam-4803	88	5	cryo	cryo	NOUN
bam-4803	88	6	-	-	PUNCT
bam-4803	88	7	em	em	PRON
bam-4803	88	8	of	of	ADP
bam-4803	88	9	the	the	DET
bam-4803	88	10	ryanodine	ryanodine	PROPN
bam-4803	88	11	receptor	receptor	NOUN
bam-4803	88	12	channel	channel	PROPN
bam-4803	88	13	eur	eur	PROPN
bam-4803	88	14	j	j	PROPN
bam-4803	88	15	transl	transl	PROPN
bam-4803	88	16	myol	myol	PROPN
bam-4803	88	17	basic	basic	ADJ
bam-4803	88	18	appl	appl	NOUN
bam-4803	88	19	myol	myol	NOUN
bam-4803	88	20	2015	2015	NUM
bam-4803	88	21	;	;	PUNCT
bam-4803	88	22	25	25	NUM
bam-4803	88	23	(	(	PUNCT
bam-4803	88	24	1	1	NUM
bam-4803	88	25	):	):	PUNCT
bam-4803	88	26	35	35	NUM
bam-4803	88	27	-	-	SYM
bam-4803	88	28	48	48	NUM
bam-4803	88	29	39	39	NUM
bam-4803	88	30	including	include	VERB
bam-4803	88	31	a	a	DET
bam-4803	88	32	horizontal	horizontal	ADJ
bam-4803	88	33	helix	helix	NOUN
bam-4803	88	34	and	and	CCONJ
bam-4803	88	35	a	a	DET
bam-4803	88	36	putative	putative	ADJ
bam-4803	88	37	pore	pore	ADJ
bam-4803	88	38	helix	helix	NOUN
bam-4803	88	39	at	at	ADP
bam-4803	88	40	the	the	DET
bam-4803	88	41	luminal	luminal	ADJ
bam-4803	88	42	side	side	NOUN
bam-4803	88	43	of	of	ADP
bam-4803	88	44	the	the	DET
bam-4803	88	45	channel	channel	NOUN
bam-4803	88	46	.	.	PUNCT
bam-4803	89	1	37,39,40	37,39,40	NUM
bam-4803	89	2	comparison	comparison	NOUN
bam-4803	89	3	of	of	ADP
bam-4803	89	4	the	the	DET
bam-4803	89	5	samso	samso	X
bam-4803	89	6	et	et	PROPN
bam-4803	89	7	al	al	PROPN
bam-4803	89	8	.	.	PROPN
bam-4803	89	9	structures	structure	NOUN
bam-4803	89	10	of	of	ADP
bam-4803	89	11	the	the	DET
bam-4803	89	12	closed	closed	ADJ
bam-4803	89	13	and	and	CCONJ
bam-4803	89	14	open	open	ADJ
bam-4803	89	15	states	state	NOUN
bam-4803	89	16	indicated	indicate	VERB
bam-4803	89	17	that	that	SCONJ
bam-4803	89	18	the	the	DET
bam-4803	89	19	inner	inner	ADJ
bam-4803	89	20	helices	helix	NOUN
bam-4803	89	21	kink	kink	VERB
bam-4803	89	22	in	in	ADP
bam-4803	89	23	order	order	NOUN
bam-4803	89	24	to	to	PART
bam-4803	89	25	widen	widen	VERB
bam-4803	89	26	the	the	DET
bam-4803	89	27	pore	pore	NOUN
bam-4803	89	28	allowing	allow	VERB
bam-4803	89	29	ions	ion	NOUN
bam-4803	89	30	to	to	PART
bam-4803	89	31	pass	pass	VERB
bam-4803	89	32	through	through	ADP
bam-4803	89	33	the	the	DET
bam-4803	89	34	membrane	membrane	NOUN
bam-4803	89	35	.	.	PUNCT
bam-4803	90	1	41	41	NUM
bam-4803	90	2	whereas	whereas	SCONJ
bam-4803	90	3	the	the	DET
bam-4803	90	4	ludtke	ludtke	PROPN
bam-4803	90	5	et	et	PROPN
bam-4803	90	6	al	al	PROPN
bam-4803	90	7	.	.	PROPN
bam-4803	90	8	structure	structure	PROPN
bam-4803	90	9	showed	show	VERB
bam-4803	90	10	that	that	SCONJ
bam-4803	90	11	the	the	DET
bam-4803	90	12	inner	inner	ADJ
bam-4803	90	13	helices	helix	NOUN
bam-4803	90	14	were	be	AUX
bam-4803	90	15	already	already	ADV
bam-4803	90	16	kinked	kink	VERB
bam-4803	90	17	in	in	ADP
bam-4803	90	18	the	the	DET
bam-4803	90	19	closed	closed	ADJ
bam-4803	90	20	state	state	NOUN
bam-4803	90	21	.	.	PUNCT
bam-4803	91	1	37	37	NUM
bam-4803	91	2	subtle	subtle	ADJ
bam-4803	91	3	differences	difference	NOUN
bam-4803	91	4	in	in	ADP
bam-4803	91	5	handling	handle	VERB
bam-4803	91	6	the	the	DET
bam-4803	91	7	protein	protein	NOUN
bam-4803	91	8	,	,	PUNCT
bam-4803	91	9	such	such	ADJ
bam-4803	91	10	as	as	ADP
bam-4803	91	11	freeze	freeze	NOUN
bam-4803	91	12	-	-	PUNCT
bam-4803	91	13	thawing	thaw	VERB
bam-4803	91	14	the	the	DET
bam-4803	91	15	sample	sample	NOUN
bam-4803	91	16	prior	prior	ADV
bam-4803	91	17	to	to	ADP
bam-4803	91	18	vitrification	vitrification	NOUN
bam-4803	91	19	,	,	PUNCT
bam-4803	91	20	cryospecimen	cryospeciman	NOUN
bam-4803	91	21	preparation	preparation	NOUN
bam-4803	91	22	or	or	CCONJ
bam-4803	91	23	imaging	imaging	NOUN
bam-4803	91	24	conditions	condition	NOUN
bam-4803	91	25	may	may	AUX
bam-4803	91	26	be	be	AUX
bam-4803	91	27	at	at	ADP
bam-4803	91	28	the	the	DET
bam-4803	91	29	root	root	NOUN
bam-4803	91	30	of	of	ADP
bam-4803	91	31	such	such	ADJ
bam-4803	91	32	ambiguity	ambiguity	NOUN
bam-4803	91	33	,	,	PUNCT
bam-4803	91	34	and	and	CCONJ
bam-4803	91	35	higher	high	ADJ
bam-4803	91	36	resolution	resolution	NOUN
bam-4803	91	37	structures	structure	NOUN
bam-4803	91	38	are	be	AUX
bam-4803	91	39	ultimately	ultimately	ADV
bam-4803	91	40	necessary	necessary	ADJ
bam-4803	91	41	to	to	PART
bam-4803	91	42	address	address	VERB
bam-4803	91	43	the	the	DET
bam-4803	91	44	transmembrane	transmembrane	ADJ
bam-4803	91	45	domain	domain	NOUN
bam-4803	91	46	helical	helical	ADJ
bam-4803	91	47	arrangement	arrangement	NOUN
bam-4803	91	48	and	and	CCONJ
bam-4803	91	49	gating	gating	NOUN
bam-4803	91	50	mechanism	mechanism	NOUN
bam-4803	91	51	.	.	PUNCT
bam-4803	92	1	furthermore	furthermore	ADV
bam-4803	92	2	,	,	PUNCT
bam-4803	92	3	modeling	modeling	NOUN
bam-4803	92	4	of	of	ADP
bam-4803	92	5	ion	ion	NOUN
bam-4803	92	6	permeation	permeation	NOUN
bam-4803	92	7	pathway	pathway	NOUN
bam-4803	92	8	of	of	ADP
bam-4803	92	9	the	the	DET
bam-4803	92	10	ryr	ryr	NOUN
bam-4803	92	11	channels	channel	NOUN
bam-4803	92	12	has	have	AUX
bam-4803	92	13	substantially	substantially	ADV
bam-4803	92	14	advanced	advance	VERB
bam-4803	92	15	our	our	PRON
bam-4803	92	16	understanding	understanding	NOUN
bam-4803	92	17	of	of	ADP
bam-4803	92	18	ryr1	ryr1	NOUN
bam-4803	92	19	gating	gating	NOUN
bam-4803	92	20	and	and	CCONJ
bam-4803	92	21	ion	ion	NOUN
bam-4803	92	22	conduction	conduction	NOUN
bam-4803	92	23	.	.	PUNCT
bam-4803	93	1	99,100	99,100	NUM
bam-4803	93	2	while	while	SCONJ
bam-4803	93	3	these	these	DET
bam-4803	93	4	studies	study	NOUN
bam-4803	93	5	are	be	AUX
bam-4803	93	6	highly	highly	ADV
bam-4803	93	7	important	important	ADJ
bam-4803	93	8	and	and	CCONJ
bam-4803	93	9	combine	combine	VERB
bam-4803	93	10	vast	vast	ADJ
bam-4803	93	11	research	research	NOUN
bam-4803	93	12	data	datum	NOUN
bam-4803	93	13	on	on	ADP
bam-4803	93	14	ryr	ryr	NOUN
bam-4803	93	15	function	function	NOUN
bam-4803	93	16	and	and	CCONJ
bam-4803	93	17	based	base	VERB
bam-4803	93	18	primary	primary	NOUN
bam-4803	93	19	on	on	ADP
bam-4803	93	20	available	available	ADJ
bam-4803	93	21	high	high	ADJ
bam-4803	93	22	-	-	PUNCT
bam-4803	93	23	resolution	resolution	NOUN
bam-4803	93	24	crystal	crystal	NOUN
bam-4803	93	25	structures	structure	NOUN
bam-4803	93	26	of	of	ADP
bam-4803	93	27	the	the	DET
bam-4803	93	28	kcsa	kcsa	NOUN
bam-4803	93	29	/	/	SYM
bam-4803	93	30	kvap	kvap	NOUN
bam-4803	93	31	/	/	SYM
bam-4803	93	32	shaker	shaker	NOUN
bam-4803	93	33	channels	channel	NOUN
bam-4803	93	34	,	,	PUNCT
bam-4803	93	35	they	they	PRON
bam-4803	93	36	are	be	AUX
bam-4803	93	37	out	out	ADP
bam-4803	93	38	of	of	ADP
bam-4803	93	39	scope	scope	NOUN
bam-4803	93	40	of	of	ADP
bam-4803	93	41	this	this	DET
bam-4803	93	42	review	review	NOUN
bam-4803	93	43	and	and	CCONJ
bam-4803	93	44	will	will	AUX
bam-4803	93	45	not	not	PART
bam-4803	93	46	be	be	AUX
bam-4803	93	47	discussed	discuss	VERB
bam-4803	93	48	here	here	ADV
bam-4803	93	49	.	.	PUNCT
bam-4803	94	1	although	although	SCONJ
bam-4803	94	2	all	all	PRON
bam-4803	94	3	of	of	ADP
bam-4803	94	4	the	the	DET
bam-4803	94	5	previous	previous	ADJ
bam-4803	94	6	studies	study	NOUN
bam-4803	94	7	used	use	VERB
bam-4803	94	8	conventionally	conventionally	ADV
bam-4803	94	9	accepted	accept	VERB
bam-4803	94	10	methods	method	NOUN
bam-4803	94	11	for	for	ADP
bam-4803	94	12	resolution	resolution	NOUN
bam-4803	94	13	determination	determination	NOUN
bam-4803	94	14	,	,	PUNCT
bam-4803	94	15	currently	currently	ADV
bam-4803	94	16	a	a	DET
bam-4803	94	17	more	more	ADV
bam-4803	94	18	stringent	stringent	ADJ
bam-4803	94	19	estimation	estimation	NOUN
bam-4803	94	20	of	of	ADP
bam-4803	94	21	resolution	resolution	NOUN
bam-4803	94	22	via	via	ADP
bam-4803	94	23	the	the	DET
bam-4803	94	24	‘	'	PUNCT
bam-4803	94	25	gold	gold	ADJ
bam-4803	94	26	standard	standard	NOUN
bam-4803	94	27	’	'	PUNCT
bam-4803	94	28	method	method	NOUN
bam-4803	94	29	has	have	AUX
bam-4803	94	30	now	now	ADV
bam-4803	94	31	been	be	AUX
bam-4803	94	32	adopted	adopt	VERB
bam-4803	94	33	by	by	ADP
bam-4803	94	34	the	the	DET
bam-4803	94	35	cryo	cryo	NOUN
bam-4803	94	36	-	-	PUNCT
bam-4803	94	37	em	em	PRON
bam-4803	94	38	field	field	NOUN
bam-4803	94	39	making	make	VERB
bam-4803	94	40	the	the	DET
bam-4803	94	41	highest	high	ADJ
bam-4803	94	42	resolution	resolution	NOUN
bam-4803	94	43	maps	map	NOUN
bam-4803	94	44	currently	currently	ADV
bam-4803	94	45	available	available	ADJ
bam-4803	94	46	for	for	ADP
bam-4803	94	47	ryr1	ryr1	NOUN
bam-4803	94	48	more	more	ADV
bam-4803	94	49	appropriately	appropriately	ADV
bam-4803	94	50	estimated	estimate	VERB
bam-4803	94	51	at	at	ADP
bam-4803	94	52	~12	~12	NOUN
bam-4803	94	53	-	-	SYM
bam-4803	94	54	15	15	NUM
bam-4803	94	55	å	å	PROPN
bam-4803	94	56	resolution	resolution	NOUN
bam-4803	94	57	.	.	PUNCT
bam-4803	95	1	56,57	56,57	NOUN
bam-4803	95	2	it	it	PRON
bam-4803	95	3	is	be	AUX
bam-4803	95	4	also	also	ADV
bam-4803	95	5	critical	critical	ADJ
bam-4803	95	6	that	that	SCONJ
bam-4803	95	7	as	as	SCONJ
bam-4803	95	8	cryo	cryo	NOUN
bam-4803	95	9	-	-	PUNCT
bam-4803	95	10	em	em	PRON
bam-4803	95	11	produces	produce	VERB
bam-4803	95	12	higher	high	ADJ
bam-4803	95	13	resolution	resolution	NOUN
bam-4803	95	14	structures	structure	NOUN
bam-4803	95	15	that	that	SCONJ
bam-4803	95	16	these	these	DET
bam-4803	95	17	maps	map	NOUN
bam-4803	95	18	be	be	AUX
bam-4803	95	19	evaluated	evaluate	VERB
bam-4803	95	20	for	for	ADP
bam-4803	95	21	the	the	DET
bam-4803	95	22	resolvability	resolvability	NOUN
bam-4803	95	23	of	of	ADP
bam-4803	95	24	features	feature	NOUN
bam-4803	95	25	at	at	ADP
bam-4803	95	26	the	the	DET
bam-4803	95	27	claimed	claim	VERB
bam-4803	95	28	resolution	resolution	NOUN
bam-4803	95	29	whereby	whereby	SCONJ
bam-4803	95	30	-helices	-helice	NOUN
bam-4803	95	31	should	should	AUX
bam-4803	95	32	appear	appear	VERB
bam-4803	95	33	as	as	ADP
bam-4803	95	34	rod	rod	NOUN
bam-4803	95	35	-	-	PUNCT
bam-4803	95	36	like	like	ADJ
bam-4803	95	37	densities	density	NOUN
bam-4803	95	38	at	at	ADP
bam-4803	95	39	~9	~9	ADP
bam-4803	95	40	å	å	PROPN
bam-4803	95	41	and	and	CCONJ
bam-4803	95	42	a	a	DET
bam-4803	95	43	helical	helical	ADJ
bam-4803	95	44	pitch	pitch	NOUN
bam-4803	95	45	detectable	detectable	ADJ
bam-4803	95	46	at	at	ADP
bam-4803	95	47	~6	~6	ADJ
bam-4803	95	48	-	-	PUNCT
bam-4803	95	49	7	7	NUM
bam-4803	95	50	å	å	PROPN
bam-4803	95	51	resolution	resolution	NOUN
bam-4803	95	52	;	;	PUNCT
bam-4803	95	53	β	β	X
bam-4803	95	54	-	-	PUNCT
bam-4803	95	55	sheets	sheet	NOUN
bam-4803	95	56	should	should	AUX
bam-4803	95	57	appear	appear	VERB
bam-4803	95	58	as	as	SCONJ
bam-4803	95	59	planar	planar	ADJ
bam-4803	95	60	density	density	NOUN
bam-4803	95	61	at	at	ADP
bam-4803	95	62	8	8	NUM
bam-4803	95	63	-	-	SYM
bam-4803	95	64	9	9	NUM
bam-4803	95	65	å	å	NOUN
bam-4803	95	66	resolution	resolution	NOUN
bam-4803	95	67	and	and	CCONJ
bam-4803	95	68	strand	strand	NOUN
bam-4803	95	69	separation	separation	NOUN
bam-4803	95	70	should	should	AUX
bam-4803	95	71	occur	occur	VERB
bam-4803	95	72	at	at	ADP
bam-4803	95	73	~5	~5	PUNCT
bam-4803	95	74	å	å	PROPN
bam-4803	95	75	resolution	resolution	NOUN
bam-4803	95	76	or	or	CCONJ
bam-4803	95	77	better	well	ADJ
bam-4803	95	78	;	;	PUNCT
bam-4803	95	79	connectivity	connectivity	NOUN
bam-4803	95	80	between	between	ADP
bam-4803	95	81	structural	structural	ADJ
bam-4803	95	82	features	feature	NOUN
bam-4803	95	83	should	should	AUX
bam-4803	95	84	be	be	AUX
bam-4803	95	85	identifiable	identifiable	ADJ
bam-4803	95	86	at	at	ADP
bam-4803	95	87	~6	~6	NOUN
bam-4803	95	88	å	å	X
bam-4803	95	89	resolution	resolution	NOUN
bam-4803	95	90	or	or	CCONJ
bam-4803	95	91	better	well	ADJ
bam-4803	95	92	and	and	CCONJ
bam-4803	95	93	at	at	ADP
bam-4803	95	94	~4	~4	NOUN
bam-4803	95	95	å	å	PROPN
bam-4803	95	96	resolution	resolution	NOUN
bam-4803	95	97	bulky	bulky	ADJ
bam-4803	95	98	side	side	NOUN
bam-4803	95	99	chain	chain	NOUN
bam-4803	95	100	densities	density	NOUN
bam-4803	95	101	will	will	AUX
bam-4803	95	102	begin	begin	VERB
bam-4803	95	103	to	to	PART
bam-4803	95	104	appear	appear	VERB
bam-4803	95	105	and	and	CCONJ
bam-4803	95	106	the	the	DET
bam-4803	95	107	path	path	NOUN
bam-4803	95	108	through	through	ADP
bam-4803	95	109	the	the	DET
bam-4803	95	110	density	density	NOUN
bam-4803	95	111	should	should	AUX
bam-4803	95	112	be	be	AUX
bam-4803	95	113	clearly	clearly	ADV
bam-4803	95	114	resolved	resolve	VERB
bam-4803	95	115	.	.	PUNCT
bam-4803	96	1	57,58	57,58	NOUN
bam-4803	96	2	prior	prior	ADV
bam-4803	96	3	to	to	ADP
bam-4803	96	4	any	any	DET
bam-4803	96	5	soluble	soluble	ADJ
bam-4803	96	6	domains	domain	NOUN
bam-4803	96	7	of	of	ADP
bam-4803	96	8	the	the	DET
bam-4803	96	9	ryr1	ryr1	NOUN
bam-4803	96	10	channel	channel	NOUN
bam-4803	96	11	solved	solve	VERB
bam-4803	96	12	by	by	ADP
bam-4803	96	13	x	x	NOUN
bam-4803	96	14	-	-	NOUN
bam-4803	96	15	ray	ray	NOUN
bam-4803	96	16	crystallography	crystallography	NOUN
bam-4803	96	17	,	,	PUNCT
bam-4803	96	18	bioinformatics	bioinformatics	NOUN
bam-4803	96	19	and	and	CCONJ
bam-4803	96	20	density	density	NOUN
bam-4803	96	21	-	-	PUNCT
bam-4803	96	22	constrained	constrain	VERB
bam-4803	96	23	comparative	comparative	ADJ
bam-4803	96	24	modeling	modeling	NOUN
bam-4803	96	25	were	be	AUX
bam-4803	96	26	utilized	utilize	VERB
bam-4803	96	27	to	to	PART
bam-4803	96	28	generate	generate	VERB
bam-4803	96	29	a	a	DET
bam-4803	96	30	homology	homology	NOUN
bam-4803	96	31	model	model	NOUN
bam-4803	96	32	of	of	ADP
bam-4803	96	33	the	the	DET
bam-4803	96	34	ryr1	ryr1	NOUN
bam-4803	96	35	nterminal	nterminal	ADJ
bam-4803	96	36	domain	domain	NOUN
bam-4803	96	37	(	(	PUNCT
bam-4803	96	38	residues	residue	NOUN
bam-4803	96	39	12–572	12–572	NUM
bam-4803	96	40	)	)	PUNCT
bam-4803	96	41	based	base	VERB
bam-4803	96	42	on	on	ADP
bam-4803	96	43	its	its	PRON
bam-4803	96	44	high	high	ADJ
bam-4803	96	45	structural	structural	ADJ
bam-4803	96	46	homology	homology	NOUN
bam-4803	96	47	to	to	ADP
bam-4803	96	48	the	the	DET
bam-4803	96	49	n	n	NOUN
bam-4803	96	50	-	-	PUNCT
bam-4803	96	51	terminus	terminus	NOUN
bam-4803	96	52	of	of	ADP
bam-4803	96	53	the	the	DET
bam-4803	96	54	ip3	ip3	NOUN
bam-4803	96	55	receptor	receptor	NOUN
bam-4803	96	56	,	,	PUNCT
bam-4803	96	57	which	which	PRON
bam-4803	96	58	contains	contain	VERB
bam-4803	96	59	the	the	DET
bam-4803	96	60	ip3	ip3	NOUN
bam-4803	96	61	binding	binding	NOUN
bam-4803	96	62	and	and	CCONJ
bam-4803	96	63	suppressor	suppressor	NOUN
bam-4803	96	64	domains	domain	NOUN
bam-4803	96	65	.	.	PUNCT
bam-4803	97	1	39	39	NUM
bam-4803	97	2	this	this	DET
bam-4803	97	3	model	model	NOUN
bam-4803	97	4	was	be	AUX
bam-4803	97	5	later	later	ADV
bam-4803	97	6	confirmed	confirm	VERB
bam-4803	97	7	by	by	ADP
bam-4803	97	8	x	x	NOUN
bam-4803	97	9	-	-	NOUN
bam-4803	97	10	ray	ray	NOUN
bam-4803	97	11	crystallography	crystallography	NOUN
bam-4803	97	12	of	of	ADP
bam-4803	97	13	the	the	DET
bam-4803	97	14	ryr1	ryr1	NOUN
bam-4803	97	15	n	n	CCONJ
bam-4803	97	16	-	-	PUNCT
bam-4803	97	17	terminus	terminus	NOUN
bam-4803	97	18	.	.	PUNCT
bam-4803	98	1	the	the	DET
bam-4803	98	2	n	n	CCONJ
bam-4803	98	3	-	-	PUNCT
bam-4803	98	4	terminal	terminal	ADJ
bam-4803	98	5	structure	structure	NOUN
bam-4803	98	6	contains	contain	VERB
bam-4803	98	7	three	three	NUM
bam-4803	98	8	domains	domain	NOUN
bam-4803	98	9	composed	compose	VERB
bam-4803	98	10	of	of	ADP
bam-4803	98	11	two	two	NUM
bam-4803	98	12	β	β	NOUN
bam-4803	98	13	-	-	PUNCT
bam-4803	98	14	trefoil	trefoil	NOUN
bam-4803	98	15	structures	structure	NOUN
bam-4803	98	16	(	(	PUNCT
bam-4803	98	17	residues	residue	VERB
bam-4803	98	18	1–205	1–205	NUM
bam-4803	98	19	and	and	CCONJ
bam-4803	98	20	206	206	NUM
bam-4803	98	21	–	–	PUNCT
bam-4803	98	22	394	394	NUM
bam-4803	98	23	)	)	PUNCT
bam-4803	98	24	followed	follow	VERB
bam-4803	98	25	by	by	ADP
bam-4803	98	26	a	a	DET
bam-4803	98	27	bundle	bundle	NOUN
bam-4803	98	28	of	of	ADP
bam-4803	98	29	five	five	NUM
bam-4803	98	30	α	α	NOUN
bam-4803	98	31	-	-	PUNCT
bam-4803	98	32	helices	helix	NOUN
bam-4803	98	33	(	(	PUNCT
bam-4803	98	34	residues	residue	NOUN
bam-4803	98	35	395–532	395–532	NUM
bam-4803	98	36	)	)	PUNCT
bam-4803	98	37	.	.	PUNCT
bam-4803	99	1	59	59	NUM
bam-4803	99	2	while	while	NOUN
bam-4803	99	3	structurally	structurally	ADV
bam-4803	99	4	similar	similar	ADJ
bam-4803	99	5	to	to	ADP
bam-4803	99	6	the	the	DET
bam-4803	99	7	ip3	ip3	NOUN
bam-4803	99	8	binding	bind	VERB
bam-4803	99	9	domain	domain	NOUN
bam-4803	99	10	,	,	PUNCT
bam-4803	99	11	ryr1	ryr1	NOUN
bam-4803	99	12	channel	channel	NOUN
bam-4803	99	13	can	can	AUX
bam-4803	99	14	not	not	PART
bam-4803	99	15	bind	bind	VERB
bam-4803	99	16	or	or	CCONJ
bam-4803	99	17	be	be	AUX
bam-4803	99	18	regulated	regulate	VERB
bam-4803	99	19	by	by	ADP
bam-4803	99	20	ip	ip	NOUN
bam-4803	99	21	3	3	NUM
bam-4803	99	22	.	.	PUNCT
bam-4803	100	1	however	however	ADV
bam-4803	100	2	,	,	PUNCT
bam-4803	100	3	over	over	ADP
bam-4803	100	4	30	30	NUM
bam-4803	100	5	disease	disease	NOUN
bam-4803	100	6	-	-	PUNCT
bam-4803	100	7	associated	associate	VERB
bam-4803	100	8	mutations	mutation	NOUN
bam-4803	100	9	are	be	AUX
bam-4803	100	10	found	find	VERB
bam-4803	100	11	in	in	ADP
bam-4803	100	12	the	the	DET
bam-4803	100	13	ryr1	ryr1	NOUN
bam-4803	100	14	n	n	CCONJ
bam-4803	100	15	-	-	PUNCT
bam-4803	100	16	terminal	terminal	ADJ
bam-4803	100	17	domain	domain	NOUN
bam-4803	100	18	that	that	PRON
bam-4803	100	19	are	be	AUX
bam-4803	100	20	proposed	propose	VERB
bam-4803	100	21	to	to	PART
bam-4803	100	22	affect	affect	VERB
bam-4803	100	23	channel	channel	NOUN
bam-4803	100	24	function	function	NOUN
bam-4803	100	25	by	by	ADP
bam-4803	100	26	protein	protein	NOUN
bam-4803	100	27	misfolding	misfolding	NOUN
bam-4803	100	28	or	or	CCONJ
bam-4803	100	29	destabilization	destabilization	NOUN
bam-4803	100	30	of	of	ADP
bam-4803	100	31	interand	interand	VERB
bam-4803	100	32	intra	intra	ADJ
bam-4803	100	33	domain	domain	NOUN
bam-4803	100	34	interactions	interaction	NOUN
bam-4803	100	35	.	.	PUNCT
bam-4803	101	1	fitting	fit	VERB
bam-4803	101	2	of	of	ADP
bam-4803	101	3	the	the	DET
bam-4803	101	4	x	x	ADJ
bam-4803	101	5	-	-	NOUN
bam-4803	101	6	ray	ray	NOUN
bam-4803	101	7	structure	structure	NOUN
bam-4803	101	8	into	into	ADP
bam-4803	101	9	the	the	DET
bam-4803	101	10	ryr1	ryr1	NOUN
bam-4803	101	11	cryo	cryo	PROPN
bam-4803	101	12	-	-	PUNCT
bam-4803	101	13	em	em	PRON
bam-4803	101	14	density	density	NOUN
bam-4803	101	15	maps	map	NOUN
bam-4803	101	16	yielded	yield	VERB
bam-4803	101	17	two	two	NUM
bam-4803	101	18	feasible	feasible	ADJ
bam-4803	101	19	locations	location	NOUN
bam-4803	101	20	,	,	PUNCT
bam-4803	101	21	one	one	NUM
bam-4803	101	22	in	in	ADP
bam-4803	101	23	the	the	DET
bam-4803	101	24	clamp	clamp	NOUN
bam-4803	101	25	domain	domain	NOUN
bam-4803	101	26	and	and	CCONJ
bam-4803	101	27	one	one	NUM
bam-4803	101	28	in	in	ADP
bam-4803	101	29	the	the	DET
bam-4803	101	30	central	central	ADJ
bam-4803	101	31	cytoplasmic	cytoplasmic	ADJ
bam-4803	101	32	vestibule	vestibule	NOUN
bam-4803	101	33	.	.	PUNCT
bam-4803	102	1	39,59	39,59	NUM
bam-4803	102	2	a	a	DET
bam-4803	102	3	structural	structural	ADJ
bam-4803	102	4	model	model	NOUN
bam-4803	102	5	of	of	ADP
bam-4803	102	6	an	an	DET
bam-4803	102	7	additional	additional	ADJ
bam-4803	102	8	functional	functional	ADJ
bam-4803	102	9	domain	domain	NOUN
bam-4803	102	10	of	of	ADP
bam-4803	102	11	the	the	DET
bam-4803	102	12	channel	channel	NOUN
bam-4803	102	13	was	be	AUX
bam-4803	102	14	determined	determine	VERB
bam-4803	102	15	by	by	ADP
bam-4803	102	16	x	x	NOUN
bam-4803	102	17	-	-	NOUN
bam-4803	102	18	ray	ray	NOUN
bam-4803	102	19	crystallography	crystallography	NOUN
bam-4803	102	20	for	for	ADP
bam-4803	102	21	ryr1	ryr1	NOUN
bam-4803	102	22	residues	residue	NOUN
bam-4803	102	23	2734	2734	NUM
bam-4803	102	24	-	-	SYM
bam-4803	102	25	2940	2940	NUM
bam-4803	102	26	,	,	PUNCT
bam-4803	102	27	which	which	PRON
bam-4803	102	28	contains	contain	VERB
bam-4803	102	29	11	11	NUM
bam-4803	102	30	disease	disease	NOUN
bam-4803	102	31	-	-	PUNCT
bam-4803	102	32	associated	associate	VERB
bam-4803	102	33	mutations	mutation	NOUN
bam-4803	102	34	and	and	CCONJ
bam-4803	102	35	a	a	DET
bam-4803	102	36	pka	pka	PROPN
bam-4803	102	37	phosphorylation	phosphorylation	NOUN
bam-4803	102	38	site	site	NOUN
bam-4803	102	39	.	.	PUNCT
bam-4803	103	1	60	60	NUM
bam-4803	103	2	the	the	DET
bam-4803	103	3	domain	domain	NOUN
bam-4803	103	4	is	be	AUX
bam-4803	103	5	a	a	DET
bam-4803	103	6	two	two	NUM
bam-4803	103	7	-	-	PUNCT
bam-4803	103	8	fold	fold	ADJ
bam-4803	103	9	symmetrical	symmetrical	ADJ
bam-4803	103	10	structure	structure	NOUN
bam-4803	103	11	with	with	ADP
bam-4803	103	12	each	each	DET
bam-4803	103	13	half	half	NOUN
bam-4803	103	14	containing	contain	VERB
bam-4803	103	15	two	two	NUM
bam-4803	103	16	αhelices	αhelice	NOUN
bam-4803	103	17	,	,	PUNCT
bam-4803	103	18	one	one	NUM
bam-4803	103	19	or	or	CCONJ
bam-4803	103	20	more	more	ADV
bam-4803	103	21	short	short	ADJ
bam-4803	103	22	310	310	NUM
bam-4803	103	23	helices	helix	NOUN
bam-4803	103	24	and	and	CCONJ
bam-4803	103	25	a	a	DET
bam-4803	103	26	c	c	NOUN
bam-4803	103	27	-	-	PUNCT
bam-4803	103	28	terminal	terminal	ADJ
bam-4803	103	29	β	β	NOUN
bam-4803	103	30	-	-	NOUN
bam-4803	103	31	strand	strand	NOUN
bam-4803	103	32	with	with	ADP
bam-4803	103	33	the	the	DET
bam-4803	103	34	halves	half	NOUN
bam-4803	103	35	separated	separate	VERB
bam-4803	103	36	by	by	ADP
bam-4803	103	37	a	a	DET
bam-4803	103	38	long	long	ADJ
bam-4803	103	39	,	,	PUNCT
bam-4803	103	40	flexible	flexible	ADJ
bam-4803	103	41	loop	loop	NOUN
bam-4803	103	42	containing	contain	VERB
bam-4803	103	43	the	the	DET
bam-4803	103	44	phosphorylation	phosphorylation	NOUN
bam-4803	103	45	site	site	NOUN
bam-4803	103	46	.	.	PUNCT
bam-4803	104	1	this	this	DET
bam-4803	104	2	structure	structure	NOUN
bam-4803	104	3	was	be	AUX
bam-4803	104	4	computationally	computationally	ADV
bam-4803	104	5	fitted	fit	VERB
bam-4803	104	6	into	into	ADP
bam-4803	104	7	the	the	DET
bam-4803	104	8	clamp	clamp	NOUN
bam-4803	104	9	domain	domain	NOUN
bam-4803	104	10	of	of	ADP
bam-4803	104	11	the	the	DET
bam-4803	104	12	cryo	cryo	NOUN
bam-4803	104	13	-	-	PUNCT
bam-4803	104	14	em	em	PROPN
bam-4803	104	15	3d	3d	NUM
bam-4803	104	16	structure	structure	NOUN
bam-4803	104	17	of	of	ADP
bam-4803	104	18	the	the	DET
bam-4803	104	19	tetrameric	tetrameric	ADJ
bam-4803	104	20	ryr1	ryr1	NOUN
bam-4803	104	21	channel	channel	NOUN
bam-4803	104	22	.	.	PUNCT
bam-4803	105	1	60	60	NUM
bam-4803	105	2	however	however	ADV
bam-4803	105	3	,	,	PUNCT
bam-4803	105	4	caution	caution	NOUN
bam-4803	105	5	should	should	AUX
bam-4803	105	6	be	be	AUX
bam-4803	105	7	used	use	VERB
bam-4803	105	8	when	when	SCONJ
bam-4803	105	9	docking	dock	VERB
bam-4803	105	10	small	small	ADJ
bam-4803	105	11	domains	domain	NOUN
bam-4803	105	12	into	into	ADP
bam-4803	105	13	very	very	ADV
bam-4803	105	14	large	large	ADJ
bam-4803	105	15	density	density	NOUN
bam-4803	105	16	maps	map	NOUN
bam-4803	105	17	.	.	PUNCT
bam-4803	106	1	61	61	NUM
bam-4803	106	2	at	at	ADP
bam-4803	106	3	intermediate	intermediate	ADJ
bam-4803	106	4	resolutions	resolution	NOUN
bam-4803	106	5	(	(	PUNCT
bam-4803	106	6	coarser	coarse	ADJ
bam-4803	106	7	than	than	ADP
bam-4803	106	8	1	1	NUM
bam-4803	106	9	nm	nm	NOUN
bam-4803	106	10	)	)	PUNCT
bam-4803	106	11	,	,	PUNCT
bam-4803	106	12	secondary	secondary	ADJ
bam-4803	106	13	structure	structure	NOUN
bam-4803	106	14	elements	element	NOUN
bam-4803	106	15	are	be	AUX
bam-4803	106	16	marginally	marginally	ADV
bam-4803	106	17	detectable	detectable	ADJ
bam-4803	106	18	and	and	CCONJ
bam-4803	106	19	remain	remain	VERB
bam-4803	106	20	unresolved	unresolved	ADJ
bam-4803	106	21	in	in	ADP
bam-4803	106	22	a	a	DET
bam-4803	106	23	majority	majority	NOUN
bam-4803	106	24	of	of	ADP
bam-4803	106	25	protein	protein	NOUN
bam-4803	106	26	densities	density	NOUN
bam-4803	106	27	,	,	PUNCT
bam-4803	106	28	resulting	result	VERB
bam-4803	106	29	in	in	ADP
bam-4803	106	30	too	too	ADV
bam-4803	106	31	little	little	ADJ
bam-4803	106	32	structural	structural	ADJ
bam-4803	106	33	information	information	NOUN
bam-4803	106	34	to	to	PART
bam-4803	106	35	anchor	anchor	VERB
bam-4803	106	36	and	and	CCONJ
bam-4803	106	37	unambiguously	unambiguously	ADV
bam-4803	106	38	validate	validate	VERB
bam-4803	106	39	fits	fit	NOUN
bam-4803	106	40	.	.	PUNCT
bam-4803	107	1	in	in	ADP
bam-4803	107	2	this	this	DET
bam-4803	107	3	situation	situation	NOUN
bam-4803	107	4	,	,	PUNCT
bam-4803	107	5	the	the	DET
bam-4803	107	6	validity	validity	NOUN
bam-4803	107	7	of	of	ADP
bam-4803	107	8	the	the	DET
bam-4803	107	9	x	x	ADJ
bam-4803	107	10	-	-	NOUN
bam-4803	107	11	ray	ray	NOUN
bam-4803	107	12	model	model	NOUN
bam-4803	107	13	fit	fit	PROPN
bam-4803	107	14	-	-	PUNCT
bam-4803	107	15	to	to	ADP
bam-4803	107	16	-	-	PUNCT
bam-4803	107	17	density	density	NOUN
bam-4803	107	18	is	be	AUX
bam-4803	107	19	limited	limit	VERB
bam-4803	107	20	by	by	ADP
bam-4803	107	21	the	the	DET
bam-4803	107	22	resolution	resolution	NOUN
bam-4803	107	23	of	of	ADP
bam-4803	107	24	the	the	DET
bam-4803	107	25	cryo	cryo	NOUN
bam-4803	107	26	-	-	PUNCT
bam-4803	107	27	em	em	PROPN
bam-4803	107	28	density	density	NOUN
bam-4803	107	29	map	map	NOUN
bam-4803	107	30	and	and	CCONJ
bam-4803	107	31	the	the	DET
bam-4803	107	32	low	low	ADJ
bam-4803	107	33	resolvability	resolvability	NOUN
bam-4803	107	34	of	of	ADP
bam-4803	107	35	features	feature	NOUN
bam-4803	107	36	in	in	ADP
bam-4803	107	37	the	the	DET
bam-4803	107	38	map	map	NOUN
bam-4803	107	39	can	can	AUX
bam-4803	107	40	leads	lead	VERB
bam-4803	107	41	to	to	ADP
bam-4803	107	42	an	an	DET
bam-4803	107	43	imperfect	imperfect	ADJ
bam-4803	107	44	match	match	NOUN
bam-4803	107	45	.	.	PUNCT
bam-4803	108	1	it	it	PRON
bam-4803	108	2	is	be	AUX
bam-4803	108	3	clear	clear	ADJ
bam-4803	108	4	that	that	SCONJ
bam-4803	108	5	a	a	DET
bam-4803	108	6	sufficiently	sufficiently	ADV
bam-4803	108	7	high	high	ADJ
bam-4803	108	8	-	-	PUNCT
bam-4803	108	9	resolution	resolution	NOUN
bam-4803	108	10	cryo	cryo	NOUN
bam-4803	108	11	-	-	PUNCT
bam-4803	108	12	em	em	PRON
bam-4803	108	13	map	map	NOUN
bam-4803	108	14	of	of	ADP
bam-4803	108	15	the	the	DET
bam-4803	108	16	fulllength	fulllength	NOUN
bam-4803	108	17	channel	channel	NOUN
bam-4803	108	18	(	(	PUNCT
bam-4803	108	19	<	<	X
bam-4803	108	20	1	1	NUM
bam-4803	108	21	nm	nm	NOUN
bam-4803	108	22	resolution	resolution	NOUN
bam-4803	108	23	based	base	VERB
bam-4803	108	24	on	on	ADP
bam-4803	108	25	the	the	DET
bam-4803	108	26	gold	gold	ADJ
bam-4803	108	27	standard	standard	ADJ
bam-4803	108	28	criteria	criterion	NOUN
bam-4803	108	29	)	)	PUNCT
bam-4803	108	30	,	,	PUNCT
bam-4803	108	31	such	such	ADJ
bam-4803	108	32	that	that	SCONJ
bam-4803	108	33	secondary	secondary	ADJ
bam-4803	108	34	structures	structure	NOUN
bam-4803	108	35	become	become	AUX
bam-4803	108	36	better	well	ADV
bam-4803	108	37	resolved	resolve	VERB
bam-4803	108	38	,	,	PUNCT
bam-4803	108	39	is	be	AUX
bam-4803	108	40	required	require	VERB
bam-4803	108	41	to	to	PART
bam-4803	108	42	reconcile	reconcile	VERB
bam-4803	108	43	the	the	DET
bam-4803	108	44	placement	placement	NOUN
bam-4803	108	45	of	of	ADP
bam-4803	108	46	domains	domain	NOUN
bam-4803	108	47	and	and	CCONJ
bam-4803	108	48	to	to	PART
bam-4803	108	49	provide	provide	VERB
bam-4803	108	50	a	a	DET
bam-4803	108	51	structural	structural	ADJ
bam-4803	108	52	context	context	NOUN
bam-4803	108	53	for	for	ADP
bam-4803	108	54	ryr1	ryr1	NOUN
bam-4803	108	55	function	function	NOUN
bam-4803	108	56	.	.	PUNCT
bam-4803	109	1	while	while	SCONJ
bam-4803	109	2	the	the	DET
bam-4803	109	3	current	current	ADJ
bam-4803	109	4	state	state	NOUN
bam-4803	109	5	of	of	ADP
bam-4803	109	6	the	the	DET
bam-4803	109	7	art	art	NOUN
bam-4803	109	8	technology	technology	NOUN
bam-4803	109	9	is	be	AUX
bam-4803	109	10	available	available	ADJ
bam-4803	109	11	for	for	ADP
bam-4803	109	12	producing	produce	VERB
bam-4803	109	13	nearatomic	nearatomic	ADJ
bam-4803	109	14	resolution	resolution	NOUN
bam-4803	109	15	structures	structure	NOUN
bam-4803	109	16	using	use	VERB
bam-4803	109	17	cryo	cryo	NOUN
bam-4803	109	18	-	-	PUNCT
bam-4803	109	19	em	em	PROPN
bam-4803	109	20	,	,	PUNCT
bam-4803	109	21	cryospecimen	cryospeciman	NOUN
bam-4803	109	22	preparation	preparation	NOUN
bam-4803	109	23	is	be	AUX
bam-4803	109	24	now	now	ADV
bam-4803	109	25	,	,	PUNCT
bam-4803	109	26	more	more	ADJ
bam-4803	109	27	than	than	ADP
bam-4803	109	28	ever	ever	ADV
bam-4803	109	29	,	,	PUNCT
bam-4803	109	30	key	key	ADJ
bam-4803	109	31	to	to	ADP
bam-4803	109	32	achieving	achieve	VERB
bam-4803	109	33	improved	improved	ADJ
bam-4803	109	34	resolution	resolution	NOUN
bam-4803	109	35	density	density	NOUN
bam-4803	109	36	maps	map	NOUN
bam-4803	109	37	for	for	ADP
bam-4803	109	38	ryr1	ryr1	NOUN
bam-4803	109	39	.	.	PUNCT
bam-4803	110	1	cryo	cryo	PROPN
bam-4803	110	2	-	-	PUNCT
bam-4803	110	3	em	em	PRON
bam-4803	110	4	imaging	imaging	NOUN
bam-4803	110	5	of	of	ADP
bam-4803	110	6	membrane	membrane	NOUN
bam-4803	110	7	proteins	protein	NOUN
bam-4803	110	8	in	in	ADP
bam-4803	110	9	detergents	detergent	NOUN
bam-4803	110	10	due	due	ADP
bam-4803	110	11	to	to	ADP
bam-4803	110	12	recent	recent	ADJ
bam-4803	110	13	technical	technical	ADJ
bam-4803	110	14	advances	advance	NOUN
bam-4803	110	15	in	in	ADP
bam-4803	110	16	the	the	DET
bam-4803	110	17	cryo	cryo	NOUN
bam-4803	110	18	-	-	PUNCT
bam-4803	110	19	em	em	PRON
bam-4803	110	20	field	field	NOUN
bam-4803	110	21	,	,	PUNCT
bam-4803	110	22	the	the	DET
bam-4803	110	23	achievable	achievable	ADJ
bam-4803	110	24	resolution	resolution	NOUN
bam-4803	110	25	for	for	ADP
bam-4803	110	26	membrane	membrane	NOUN
bam-4803	110	27	proteins	protein	NOUN
bam-4803	110	28	is	be	AUX
bam-4803	110	29	now	now	ADV
bam-4803	110	30	3	3	NUM
bam-4803	110	31	-	-	SYM
bam-4803	110	32	7	7	NUM
bam-4803	110	33	å	å	PROPN
bam-4803	110	34	,	,	PUNCT
bam-4803	110	35	13,14,62	13,14,62	NUM
bam-4803	110	36	however	however	ADJ
bam-4803	110	37	vitrification	vitrification	NOUN
bam-4803	110	38	of	of	ADP
bam-4803	110	39	membrane	membrane	NOUN
bam-4803	110	40	protein	protein	NOUN
bam-4803	110	41	samples	sample	NOUN
bam-4803	110	42	is	be	AUX
bam-4803	110	43	a	a	DET
bam-4803	110	44	critical	critical	ADJ
bam-4803	110	45	rate	rate	NOUN
bam-4803	110	46	-	-	PUNCT
bam-4803	110	47	limiting	limit	VERB
bam-4803	110	48	step	step	NOUN
bam-4803	110	49	.	.	PUNCT
bam-4803	111	1	in	in	ADP
bam-4803	111	2	single	single	ADJ
bam-4803	111	3	-	-	PUNCT
bam-4803	111	4	particle	particle	NOUN
bam-4803	111	5	cryo	cryo	NOUN
bam-4803	111	6	-	-	PUNCT
bam-4803	111	7	em	em	PROPN
bam-4803	111	8	,	,	PUNCT
bam-4803	111	9	the	the	DET
bam-4803	111	10	sample	sample	NOUN
bam-4803	111	11	is	be	AUX
bam-4803	111	12	preserved	preserve	VERB
bam-4803	111	13	in	in	ADP
bam-4803	111	14	a	a	DET
bam-4803	111	15	layer	layer	NOUN
bam-4803	111	16	of	of	ADP
bam-4803	111	17	vitreous	vitreous	ADJ
bam-4803	111	18	ice	ice	NOUN
bam-4803	111	19	and	and	CCONJ
bam-4803	111	20	visualized	visualize	VERB
bam-4803	111	21	in	in	ADP
bam-4803	111	22	the	the	DET
bam-4803	111	23	form	form	NOUN
bam-4803	111	24	of	of	ADP
bam-4803	111	25	isolated	isolated	ADJ
bam-4803	111	26	unordered	unordered	ADJ
bam-4803	111	27	particles	particle	NOUN
bam-4803	111	28	.	.	PUNCT
bam-4803	112	1	in	in	ADP
bam-4803	112	2	general	general	ADJ
bam-4803	112	3	,	,	PUNCT
bam-4803	112	4	to	to	PART
bam-4803	112	5	achieve	achieve	VERB
bam-4803	112	6	a	a	DET
bam-4803	112	7	3d	3d	NOUN
bam-4803	112	8	structure	structure	NOUN
bam-4803	112	9	using	use	VERB
bam-4803	112	10	single	single	ADJ
bam-4803	112	11	-	-	PUNCT
bam-4803	112	12	particle	particle	NOUN
bam-4803	112	13	cryo	cryo	NOUN
bam-4803	112	14	-	-	PUNCT
bam-4803	112	15	em	em	PROPN
bam-4803	112	16	,	,	PUNCT
bam-4803	112	17	the	the	DET
bam-4803	112	18	object	object	NOUN
bam-4803	112	19	that	that	PRON
bam-4803	112	20	is	be	AUX
bam-4803	112	21	vitrified	vitrify	VERB
bam-4803	112	22	must	must	AUX
bam-4803	112	23	be	be	AUX
bam-4803	112	24	monodisperse	monodisperse	ADJ
bam-4803	112	25	in	in	ADP
bam-4803	112	26	solution	solution	NOUN
bam-4803	112	27	and	and	CCONJ
bam-4803	112	28	exhibit	exhibit	VERB
bam-4803	112	29	random	random	ADJ
bam-4803	112	30	orientations	orientation	NOUN
bam-4803	112	31	.	.	PUNCT
bam-4803	113	1	a	a	DET
bam-4803	113	2	3d	3d	PROPN
bam-4803	113	3	reconstruction	reconstruction	NOUN
bam-4803	113	4	can	can	AUX
bam-4803	113	5	be	be	AUX
bam-4803	113	6	obtained	obtain	VERB
bam-4803	113	7	through	through	ADP
bam-4803	113	8	image	image	NOUN
bam-4803	113	9	processing	processing	NOUN
bam-4803	113	10	by	by	ADP
bam-4803	113	11	combining	combine	VERB
bam-4803	113	12	of	of	ADP
bam-4803	113	13	thousands	thousand	NOUN
bam-4803	113	14	of	of	ADP
bam-4803	113	15	2d	2d	NUM
bam-4803	113	16	projection	projection	NOUN
bam-4803	113	17	images	image	NOUN
bam-4803	113	18	of	of	ADP
bam-4803	113	19	the	the	DET
bam-4803	113	20	3d	3d	NUM
bam-4803	113	21	object	object	NOUN
bam-4803	113	22	being	be	AUX
bam-4803	113	23	imaged	image	VERB
bam-4803	113	24	.	.	PUNCT
bam-4803	114	1	integral	integral	ADJ
bam-4803	114	2	membrane	membrane	NOUN
bam-4803	114	3	proteins	protein	NOUN
bam-4803	114	4	naturally	naturally	ADV
bam-4803	114	5	reside	reside	VERB
bam-4803	114	6	in	in	ADP
bam-4803	114	7	a	a	DET
bam-4803	114	8	lipid	lipid	NOUN
bam-4803	114	9	bilayer	bilayer	NOUN
bam-4803	114	10	satisfying	satisfy	VERB
bam-4803	114	11	the	the	DET
bam-4803	114	12	hydrophobicity	hydrophobicity	NOUN
bam-4803	114	13	of	of	ADP
bam-4803	114	14	their	their	PRON
bam-4803	114	15	transmembrane	transmembrane	ADJ
bam-4803	114	16	domain	domain	NOUN
bam-4803	114	17	.	.	PUNCT
bam-4803	115	1	thus	thus	ADV
bam-4803	115	2	,	,	PUNCT
bam-4803	115	3	to	to	PART
bam-4803	115	4	achieve	achieve	VERB
bam-4803	115	5	vitrification	vitrification	NOUN
bam-4803	115	6	conditions	condition	NOUN
bam-4803	115	7	for	for	ADP
bam-4803	115	8	cryo	cryo	NOUN
bam-4803	115	9	-	-	PUNCT
bam-4803	115	10	em	em	PRON
bam-4803	115	11	visualization	visualization	NOUN
bam-4803	115	12	,	,	PUNCT
bam-4803	115	13	membrane	membrane	NOUN
bam-4803	115	14	proteins	protein	NOUN
bam-4803	115	15	are	be	AUX
bam-4803	115	16	extracted	extract	VERB
bam-4803	115	17	from	from	ADP
bam-4803	115	18	their	their	PRON
bam-4803	115	19	native	native	ADJ
bam-4803	115	20	single	single	ADJ
bam-4803	115	21	-	-	PUNCT
bam-4803	115	22	particle	particle	NOUN
bam-4803	115	23	cryo	cryo	NOUN
bam-4803	115	24	-	-	PUNCT
bam-4803	115	25	em	em	PRON
bam-4803	115	26	of	of	ADP
bam-4803	115	27	the	the	DET
bam-4803	115	28	ryanodine	ryanodine	PROPN
bam-4803	115	29	receptor	receptor	NOUN
bam-4803	115	30	channel	channel	PROPN
bam-4803	115	31	eur	eur	PROPN
bam-4803	115	32	j	j	PROPN
bam-4803	115	33	transl	transl	PROPN
bam-4803	115	34	myol	myol	PROPN
bam-4803	115	35	basic	basic	ADJ
bam-4803	115	36	appl	appl	NOUN
bam-4803	115	37	myol	myol	NOUN
bam-4803	115	38	2015	2015	NUM
bam-4803	115	39	;	;	PUNCT
bam-4803	115	40	25	25	NUM
bam-4803	115	41	(	(	PUNCT
bam-4803	115	42	1	1	NUM
bam-4803	115	43	):	):	PUNCT
bam-4803	115	44	35	35	NUM
bam-4803	115	45	-	-	SYM
bam-4803	115	46	48	48	NUM
bam-4803	115	47	40	40	NUM
bam-4803	115	48	membrane	membrane	NOUN
bam-4803	115	49	environment	environment	NOUN
bam-4803	115	50	and	and	CCONJ
bam-4803	115	51	imaged	image	VERB
bam-4803	115	52	in	in	ADP
bam-4803	115	53	detergentbound	detergentbound	NOUN
bam-4803	115	54	forms	form	NOUN
bam-4803	115	55	in	in	ADP
bam-4803	115	56	aqueous	aqueous	ADJ
bam-4803	115	57	solution	solution	NOUN
bam-4803	115	58	.	.	PUNCT
bam-4803	116	1	17	17	NUM
bam-4803	116	2	however	however	ADV
bam-4803	116	3	,	,	PUNCT
bam-4803	116	4	the	the	DET
bam-4803	116	5	loss	loss	NOUN
bam-4803	116	6	of	of	ADP
bam-4803	116	7	the	the	DET
bam-4803	116	8	structural	structural	ADJ
bam-4803	116	9	support	support	NOUN
bam-4803	116	10	provided	provide	VERB
bam-4803	116	11	by	by	ADP
bam-4803	116	12	the	the	DET
bam-4803	116	13	native	native	ADJ
bam-4803	116	14	membrane	membrane	NOUN
bam-4803	116	15	environment	environment	NOUN
bam-4803	116	16	can	can	AUX
bam-4803	116	17	lead	lead	VERB
bam-4803	116	18	to	to	ADP
bam-4803	116	19	destabilization	destabilization	NOUN
bam-4803	116	20	and	and	CCONJ
bam-4803	116	21	inactivation	inactivation	NOUN
bam-4803	116	22	of	of	ADP
bam-4803	116	23	membrane	membrane	NOUN
bam-4803	116	24	proteins	protein	NOUN
bam-4803	116	25	,	,	PUNCT
bam-4803	116	26	which	which	PRON
bam-4803	116	27	contributes	contribute	VERB
bam-4803	116	28	a	a	DET
bam-4803	116	29	significant	significant	ADJ
bam-4803	116	30	barrier	barrier	NOUN
bam-4803	116	31	to	to	ADP
bam-4803	116	32	membrane	membrane	NOUN
bam-4803	116	33	protein	protein	NOUN
bam-4803	116	34	research	research	NOUN
bam-4803	116	35	in	in	ADP
bam-4803	116	36	general	general	ADJ
bam-4803	116	37	.	.	PUNCT
bam-4803	117	1	63	63	NUM
bam-4803	117	2	moreover	moreover	ADV
bam-4803	117	3	,	,	PUNCT
bam-4803	117	4	cryo	cryo	NOUN
bam-4803	117	5	-	-	PUNCT
bam-4803	117	6	em	em	PRON
bam-4803	117	7	studies	study	NOUN
bam-4803	117	8	confront	confront	VERB
bam-4803	117	9	the	the	DET
bam-4803	117	10	additional	additional	ADJ
bam-4803	117	11	hurdle	hurdle	NOUN
bam-4803	117	12	of	of	ADP
bam-4803	117	13	the	the	DET
bam-4803	117	14	presence	presence	NOUN
bam-4803	117	15	of	of	ADP
bam-4803	117	16	detergent	detergent	NOUN
bam-4803	117	17	in	in	ADP
bam-4803	117	18	the	the	DET
bam-4803	117	19	sample	sample	NOUN
bam-4803	117	20	,	,	PUNCT
bam-4803	117	21	that	that	PRON
bam-4803	117	22	can	can	AUX
bam-4803	117	23	prevent	prevent	VERB
bam-4803	117	24	the	the	DET
bam-4803	117	25	particles	particle	NOUN
bam-4803	117	26	from	from	ADP
bam-4803	117	27	being	be	AUX
bam-4803	117	28	distributed	distribute	VERB
bam-4803	117	29	evenly	evenly	ADV
bam-4803	117	30	in	in	ADP
bam-4803	117	31	the	the	DET
bam-4803	117	32	embedding	embed	VERB
bam-4803	117	33	ice	ice	NOUN
bam-4803	117	34	and	and	CCONJ
bam-4803	117	35	dramatically	dramatically	ADV
bam-4803	117	36	reduce	reduce	VERB
bam-4803	117	37	the	the	DET
bam-4803	117	38	image	image	NOUN
bam-4803	117	39	contrast	contrast	NOUN
bam-4803	117	40	critical	critical	ADJ
bam-4803	117	41	to	to	ADP
bam-4803	117	42	producing	produce	VERB
bam-4803	117	43	reliable	reliable	ADJ
bam-4803	117	44	and	and	CCONJ
bam-4803	117	45	high	high	ADJ
bam-4803	117	46	-	-	PUNCT
bam-4803	117	47	resolution	resolution	NOUN
bam-4803	117	48	cryo	cryo	NOUN
bam-4803	117	49	-	-	PUNCT
bam-4803	117	50	em	em	PROPN
bam-4803	117	51	reconstruction	reconstruction	NOUN
bam-4803	117	52	.	.	PUNCT
bam-4803	118	1	64	64	NUM
bam-4803	118	2	single	single	ADJ
bam-4803	118	3	-	-	PUNCT
bam-4803	118	4	particle	particle	NOUN
bam-4803	118	5	cryo	cryo	NOUN
bam-4803	118	6	-	-	PUNCT
bam-4803	118	7	em	em	PRON
bam-4803	118	8	studies	study	NOUN
bam-4803	118	9	of	of	ADP
bam-4803	118	10	membrane	membrane	NOUN
bam-4803	118	11	proteins	protein	NOUN
bam-4803	118	12	are	be	AUX
bam-4803	118	13	substantially	substantially	ADV
bam-4803	118	14	reliant	reliant	ADJ
bam-4803	118	15	on	on	ADP
bam-4803	118	16	the	the	DET
bam-4803	118	17	successful	successful	ADJ
bam-4803	118	18	solubilization	solubilization	NOUN
bam-4803	118	19	and	and	CCONJ
bam-4803	118	20	purification	purification	NOUN
bam-4803	118	21	of	of	ADP
bam-4803	118	22	monodisperse	monodisperse	NOUN
bam-4803	118	23	,	,	PUNCT
bam-4803	118	24	isotropic	isotropic	ADJ
bam-4803	118	25	solutions	solution	NOUN
bam-4803	118	26	of	of	ADP
bam-4803	118	27	the	the	DET
bam-4803	118	28	target	target	NOUN
bam-4803	118	29	protein	protein	NOUN
bam-4803	118	30	.	.	PUNCT
bam-4803	119	1	integral	integral	ADJ
bam-4803	119	2	membrane	membrane	NOUN
bam-4803	119	3	proteins	protein	NOUN
bam-4803	119	4	exhibit	exhibit	VERB
bam-4803	119	5	a	a	DET
bam-4803	119	6	complex	complex	ADJ
bam-4803	119	7	distribution	distribution	NOUN
bam-4803	119	8	of	of	ADP
bam-4803	119	9	surface	surface	NOUN
bam-4803	119	10	charges	charge	NOUN
bam-4803	119	11	where	where	SCONJ
bam-4803	119	12	the	the	DET
bam-4803	119	13	hydrophobic	hydrophobic	ADJ
bam-4803	119	14	transmembrane	transmembrane	NOUN
bam-4803	119	15	domains	domain	NOUN
bam-4803	119	16	are	be	AUX
bam-4803	119	17	separated	separate	VERB
bam-4803	119	18	by	by	ADP
bam-4803	119	19	intervening	intervene	VERB
bam-4803	119	20	hydrophilic	hydrophilic	ADJ
bam-4803	119	21	regions	region	NOUN
bam-4803	119	22	that	that	PRON
bam-4803	119	23	are	be	AUX
bam-4803	119	24	typically	typically	ADV
bam-4803	119	25	exposed	expose	VERB
bam-4803	119	26	into	into	ADP
bam-4803	119	27	aqueous	aqueous	ADJ
bam-4803	119	28	intraor	intraor	NOUN
bam-4803	119	29	extra	extra	ADJ
bam-4803	119	30	-	-	ADJ
bam-4803	119	31	cellular	cellular	ADJ
bam-4803	119	32	environment	environment	NOUN
bam-4803	119	33	.	.	PUNCT
bam-4803	120	1	thus	thus	ADV
bam-4803	120	2	,	,	PUNCT
bam-4803	120	3	membrane	membrane	NOUN
bam-4803	120	4	proteins	protein	NOUN
bam-4803	120	5	extracted	extract	VERB
bam-4803	120	6	from	from	ADP
bam-4803	120	7	their	their	PRON
bam-4803	120	8	membranous	membranous	ADJ
bam-4803	120	9	environment	environment	NOUN
bam-4803	120	10	will	will	AUX
bam-4803	120	11	not	not	PART
bam-4803	120	12	be	be	AUX
bam-4803	120	13	watersoluble	watersoluble	ADJ
bam-4803	120	14	unless	unless	SCONJ
bam-4803	120	15	they	they	PRON
bam-4803	120	16	are	be	AUX
bam-4803	120	17	placed	place	VERB
bam-4803	120	18	in	in	ADP
bam-4803	120	19	a	a	DET
bam-4803	120	20	surrounding	surround	VERB
bam-4803	120	21	environment	environment	NOUN
bam-4803	120	22	compatible	compatible	ADJ
bam-4803	120	23	with	with	ADP
bam-4803	120	24	their	their	PRON
bam-4803	120	25	hydrophobicity	hydrophobicity	NOUN
bam-4803	120	26	.	.	PUNCT
bam-4803	121	1	due	due	ADP
bam-4803	121	2	to	to	ADP
bam-4803	121	3	their	their	PRON
bam-4803	121	4	amphipathic	amphipathic	ADJ
bam-4803	121	5	nature	nature	NOUN
bam-4803	121	6	,	,	PUNCT
bam-4803	121	7	detergents	detergent	NOUN
bam-4803	121	8	allow	allow	VERB
bam-4803	121	9	for	for	ADP
bam-4803	121	10	the	the	DET
bam-4803	121	11	removal	removal	NOUN
bam-4803	121	12	of	of	ADP
bam-4803	121	13	membrane	membrane	ADJ
bam-4803	121	14	proteins	protein	NOUN
bam-4803	121	15	from	from	ADP
bam-4803	121	16	a	a	DET
bam-4803	121	17	lipid	lipid	NOUN
bam-4803	121	18	environment	environment	NOUN
bam-4803	121	19	while	while	SCONJ
bam-4803	121	20	maintaining	maintain	VERB
bam-4803	121	21	their	their	PRON
bam-4803	121	22	solubility	solubility	NOUN
bam-4803	121	23	in	in	ADP
bam-4803	121	24	aqueous	aqueous	ADJ
bam-4803	121	25	solution	solution	NOUN
bam-4803	121	26	.	.	PUNCT
bam-4803	122	1	detergents	detergent	NOUN
bam-4803	122	2	bind	bind	VERB
bam-4803	122	3	to	to	ADP
bam-4803	122	4	hydrophobic	hydrophobic	VERB
bam-4803	122	5	transmembrane	transmembrane	NOUN
bam-4803	122	6	domains	domain	NOUN
bam-4803	122	7	of	of	ADP
bam-4803	122	8	membrane	membrane	NOUN
bam-4803	122	9	proteins	protein	NOUN
bam-4803	122	10	and	and	CCONJ
bam-4803	122	11	form	form	VERB
bam-4803	122	12	an	an	DET
bam-4803	122	13	amphipathic	amphipathic	ADJ
bam-4803	122	14	belt	belt	NOUN
bam-4803	122	15	,	,	PUNCT
bam-4803	122	16	solubilizing	solubilize	VERB
bam-4803	122	17	the	the	DET
bam-4803	122	18	protein	protein	NOUN
bam-4803	122	19	and	and	CCONJ
bam-4803	122	20	substituting	substitute	VERB
bam-4803	122	21	for	for	ADP
bam-4803	122	22	the	the	DET
bam-4803	122	23	lipid	lipid	NOUN
bam-4803	122	24	bilayer	bilayer	NOUN
bam-4803	122	25	.	.	PUNCT
bam-4803	123	1	17	17	NUM
bam-4803	123	2	these	these	DET
bam-4803	123	3	detergent	detergent	NOUN
bam-4803	123	4	belts	belt	NOUN
bam-4803	123	5	are	be	AUX
bam-4803	123	6	in	in	ADP
bam-4803	123	7	rapid	rapid	ADJ
bam-4803	123	8	equilibrium	equilibrium	NOUN
bam-4803	123	9	with	with	ADP
bam-4803	123	10	free	free	ADJ
bam-4803	123	11	detergent	detergent	NOUN
bam-4803	123	12	monomers	monomer	NOUN
bam-4803	123	13	and	and	CCONJ
bam-4803	123	14	detergent	detergent	NOUN
bam-4803	123	15	micelles	micelle	NOUN
bam-4803	123	16	.	.	PUNCT
bam-4803	124	1	thus	thus	ADV
bam-4803	124	2	,	,	PUNCT
bam-4803	124	3	the	the	DET
bam-4803	124	4	molecular	molecular	ADJ
bam-4803	124	5	properties	property	NOUN
bam-4803	124	6	and	and	CCONJ
bam-4803	124	7	physical	physical	ADJ
bam-4803	124	8	behavior	behavior	NOUN
bam-4803	124	9	of	of	ADP
bam-4803	124	10	the	the	DET
bam-4803	124	11	detergent	detergent	NOUN
bam-4803	124	12	in	in	ADP
bam-4803	124	13	the	the	DET
bam-4803	124	14	form	form	NOUN
bam-4803	124	15	of	of	ADP
bam-4803	124	16	micelle	micelle	NOUN
bam-4803	124	17	and	and	CCONJ
bam-4803	124	18	protein	protein	NOUN
bam-4803	124	19	-	-	PUNCT
bam-4803	124	20	detergent	detergent	NOUN
bam-4803	124	21	complexes	complex	NOUN
bam-4803	124	22	are	be	AUX
bam-4803	124	23	critical	critical	ADJ
bam-4803	124	24	parameters	parameter	NOUN
bam-4803	124	25	to	to	PART
bam-4803	124	26	be	be	AUX
bam-4803	124	27	considered	consider	VERB
bam-4803	124	28	and	and	CCONJ
bam-4803	124	29	controlled	control	VERB
bam-4803	124	30	in	in	ADP
bam-4803	124	31	determining	determine	VERB
bam-4803	124	32	the	the	DET
bam-4803	124	33	success	success	NOUN
bam-4803	124	34	of	of	ADP
bam-4803	124	35	single	single	ADJ
bam-4803	124	36	-	-	PUNCT
bam-4803	124	37	particle	particle	NOUN
bam-4803	124	38	cryo	cryo	NOUN
bam-4803	124	39	-	-	PUNCT
bam-4803	124	40	em	em	PRON
bam-4803	124	41	experiments	experiment	NOUN
bam-4803	124	42	.	.	PUNCT
bam-4803	125	1	the	the	DET
bam-4803	125	2	primary	primary	ADJ
bam-4803	125	3	difficulty	difficulty	NOUN
bam-4803	125	4	encountered	encounter	VERB
bam-4803	125	5	in	in	ADP
bam-4803	125	6	the	the	DET
bam-4803	125	7	singleparticle	singleparticle	NOUN
bam-4803	125	8	cryo	cryo	PROPN
bam-4803	125	9	-	-	PUNCT
bam-4803	125	10	em	em	PRON
bam-4803	125	11	study	study	NOUN
bam-4803	125	12	of	of	ADP
bam-4803	125	13	detergent	detergent	NOUN
bam-4803	125	14	-	-	PUNCT
bam-4803	125	15	bound	bind	VERB
bam-4803	125	16	membrane	membrane	NOUN
bam-4803	125	17	proteins	protein	NOUN
bam-4803	125	18	is	be	AUX
bam-4803	125	19	preparation	preparation	NOUN
bam-4803	125	20	of	of	ADP
bam-4803	125	21	cryospecimen	cryospeciman	NOUN
bam-4803	125	22	with	with	ADP
bam-4803	125	23	particles	particle	NOUN
bam-4803	125	24	being	be	AUX
bam-4803	125	25	evenly	evenly	ADV
bam-4803	125	26	distributed	distribute	VERB
bam-4803	125	27	within	within	ADP
bam-4803	125	28	a	a	DET
bam-4803	125	29	thin	thin	ADJ
bam-4803	125	30	layer	layer	NOUN
bam-4803	125	31	of	of	ADP
bam-4803	125	32	vitreous	vitreous	ADJ
bam-4803	125	33	ice	ice	NOUN
bam-4803	125	34	.	.	PUNCT
bam-4803	126	1	in	in	ADP
bam-4803	126	2	general	general	ADJ
bam-4803	126	3	,	,	PUNCT
bam-4803	126	4	vitrification	vitrification	NOUN
bam-4803	126	5	of	of	ADP
bam-4803	126	6	proteins	protein	NOUN
bam-4803	126	7	depends	depend	VERB
bam-4803	126	8	on	on	ADP
bam-4803	126	9	environmental	environmental	ADJ
bam-4803	126	10	conditions	condition	NOUN
bam-4803	126	11	such	such	ADJ
bam-4803	126	12	as	as	ADP
bam-4803	126	13	temperature	temperature	NOUN
bam-4803	126	14	,	,	PUNCT
bam-4803	126	15	humidity	humidity	NOUN
bam-4803	126	16	,	,	PUNCT
bam-4803	126	17	buffer	buffer	VERB
bam-4803	126	18	composition	composition	NOUN
bam-4803	126	19	,	,	PUNCT
bam-4803	126	20	ph	ph	ADJ
bam-4803	126	21	,	,	PUNCT
bam-4803	126	22	ionic	ionic	ADJ
bam-4803	126	23	strength	strength	NOUN
bam-4803	126	24	,	,	PUNCT
bam-4803	126	25	and	and	CCONJ
bam-4803	126	26	surface	surface	NOUN
bam-4803	126	27	properties	property	NOUN
bam-4803	126	28	of	of	ADP
bam-4803	126	29	a	a	DET
bam-4803	126	30	supporting	support	VERB
bam-4803	126	31	film	film	NOUN
bam-4803	126	32	on	on	ADP
bam-4803	126	33	em	em	PRON
bam-4803	126	34	grid	grid	NOUN
bam-4803	126	35	.	.	PUNCT
bam-4803	127	1	while	while	SCONJ
bam-4803	127	2	recent	recent	ADJ
bam-4803	127	3	development	development	NOUN
bam-4803	127	4	of	of	ADP
bam-4803	127	5	semi	semi	ADJ
bam-4803	127	6	-	-	ADJ
bam-4803	127	7	automated	automated	ADJ
bam-4803	127	8	devices	device	NOUN
bam-4803	127	9	have	have	AUX
bam-4803	127	10	significantly	significantly	ADV
bam-4803	127	11	improved	improve	VERB
bam-4803	127	12	the	the	DET
bam-4803	127	13	search	search	NOUN
bam-4803	127	14	for	for	ADP
bam-4803	127	15	optimal	optimal	ADJ
bam-4803	127	16	conditions	condition	NOUN
bam-4803	127	17	for	for	ADP
bam-4803	127	18	ice	ice	NOUN
bam-4803	127	19	-	-	PUNCT
bam-4803	127	20	embedding	embed	VERB
bam-4803	127	21	,	,	PUNCT
bam-4803	127	22	the	the	DET
bam-4803	127	23	presence	presence	NOUN
bam-4803	127	24	of	of	ADP
bam-4803	127	25	detergent	detergent	NOUN
bam-4803	127	26	in	in	ADP
bam-4803	127	27	the	the	DET
bam-4803	127	28	membrane	membrane	NOUN
bam-4803	127	29	protein	protein	NOUN
bam-4803	127	30	sample	sample	NOUN
bam-4803	127	31	adds	add	VERB
bam-4803	127	32	to	to	ADP
bam-4803	127	33	the	the	DET
bam-4803	127	34	complexity	complexity	NOUN
bam-4803	127	35	of	of	ADP
bam-4803	127	36	the	the	DET
bam-4803	127	37	system	system	NOUN
bam-4803	127	38	by	by	ADP
bam-4803	127	39	changing	change	VERB
bam-4803	127	40	the	the	DET
bam-4803	127	41	surface	surface	NOUN
bam-4803	127	42	properties	property	NOUN
bam-4803	127	43	of	of	ADP
bam-4803	127	44	its	its	PRON
bam-4803	127	45	components	component	NOUN
bam-4803	127	46	.	.	PUNCT
bam-4803	128	1	the	the	DET
bam-4803	128	2	presence	presence	NOUN
bam-4803	128	3	of	of	ADP
bam-4803	128	4	detergent	detergent	NOUN
bam-4803	128	5	in	in	ADP
bam-4803	128	6	solution	solution	NOUN
bam-4803	128	7	reduces	reduce	VERB
bam-4803	128	8	the	the	DET
bam-4803	128	9	surface	surface	NOUN
bam-4803	128	10	tension	tension	NOUN
bam-4803	128	11	of	of	ADP
bam-4803	128	12	the	the	DET
bam-4803	128	13	buffer	buffer	NOUN
bam-4803	128	14	making	make	VERB
bam-4803	128	15	it	it	PRON
bam-4803	128	16	difficult	difficult	ADJ
bam-4803	128	17	to	to	PART
bam-4803	128	18	obtain	obtain	VERB
bam-4803	128	19	uniform	uniform	ADJ
bam-4803	128	20	ice	ice	NOUN
bam-4803	128	21	film	film	NOUN
bam-4803	128	22	with	with	ADP
bam-4803	128	23	evenly	evenly	ADV
bam-4803	128	24	distributed	distribute	VERB
bam-4803	128	25	vitrified	vitrify	VERB
bam-4803	128	26	particles	particle	NOUN
bam-4803	128	27	of	of	ADP
bam-4803	128	28	membrane	membrane	NOUN
bam-4803	128	29	protein	protein	NOUN
bam-4803	128	30	.	.	PUNCT
bam-4803	129	1	particles	particle	NOUN
bam-4803	129	2	that	that	PRON
bam-4803	129	3	do	do	AUX
bam-4803	129	4	not	not	PART
bam-4803	129	5	adhere	adhere	VERB
bam-4803	129	6	to	to	ADP
bam-4803	129	7	the	the	DET
bam-4803	129	8	grid	grid	NOUN
bam-4803	129	9	or	or	CCONJ
bam-4803	129	10	form	form	VERB
bam-4803	129	11	a	a	DET
bam-4803	129	12	narrow	narrow	ADJ
bam-4803	129	13	peripheral	peripheral	ADJ
bam-4803	129	14	band	band	NOUN
bam-4803	129	15	close	close	ADJ
bam-4803	129	16	to	to	ADP
bam-4803	129	17	the	the	DET
bam-4803	129	18	edge	edge	NOUN
bam-4803	129	19	of	of	ADP
bam-4803	129	20	the	the	DET
bam-4803	129	21	hole	hole	NOUN
bam-4803	129	22	in	in	ADP
bam-4803	129	23	the	the	DET
bam-4803	129	24	cryospecimen	cryospeciman	NOUN
bam-4803	129	25	is	be	AUX
bam-4803	129	26	a	a	DET
bam-4803	129	27	common	common	ADJ
bam-4803	129	28	obstacle	obstacle	NOUN
bam-4803	129	29	in	in	ADP
bam-4803	129	30	singleparticle	singleparticle	PROPN
bam-4803	129	31	cryo	cryo	PROPN
bam-4803	129	32	-	-	PUNCT
bam-4803	129	33	em	em	PRON
bam-4803	129	34	studies	study	NOUN
bam-4803	129	35	of	of	ADP
bam-4803	129	36	membrane	membrane	NOUN
bam-4803	129	37	proteins	protein	NOUN
bam-4803	129	38	.	.	PUNCT
bam-4803	130	1	this	this	PRON
bam-4803	130	2	is	be	AUX
bam-4803	130	3	disadvantageous	disadvantageous	ADJ
bam-4803	130	4	to	to	ADP
bam-4803	130	5	cryo	cryo	NOUN
bam-4803	130	6	-	-	PUNCT
bam-4803	130	7	em	em	PROPN
bam-4803	130	8	data	datum	NOUN
bam-4803	130	9	collection	collection	NOUN
bam-4803	130	10	since	since	SCONJ
bam-4803	130	11	imaging	image	VERB
bam-4803	130	12	fields	field	NOUN
bam-4803	130	13	often	often	ADV
bam-4803	130	14	yields	yield	VERB
bam-4803	130	15	only	only	ADV
bam-4803	130	16	few	few	ADJ
bam-4803	130	17	membrane	membrane	NOUN
bam-4803	130	18	protein	protein	NOUN
bam-4803	130	19	particles	particle	NOUN
bam-4803	130	20	per	per	ADP
bam-4803	130	21	frame	frame	NOUN
bam-4803	130	22	.	.	PUNCT
bam-4803	131	1	to	to	PART
bam-4803	131	2	overcome	overcome	VERB
bam-4803	131	3	this	this	DET
bam-4803	131	4	difficulty	difficulty	NOUN
bam-4803	131	5	,	,	PUNCT
bam-4803	131	6	a	a	DET
bam-4803	131	7	continuous	continuous	ADJ
bam-4803	131	8	carbon	carbon	NOUN
bam-4803	131	9	film	film	NOUN
bam-4803	131	10	is	be	AUX
bam-4803	131	11	often	often	ADV
bam-4803	131	12	used	use	VERB
bam-4803	131	13	to	to	PART
bam-4803	131	14	improve	improve	VERB
bam-4803	131	15	adhering	adhere	VERB
bam-4803	131	16	particles	particle	NOUN
bam-4803	131	17	to	to	ADP
bam-4803	131	18	the	the	DET
bam-4803	131	19	em	em	PROPN
bam-4803	131	20	grid	grid	NOUN
bam-4803	131	21	(	(	PUNCT
bam-4803	131	22	reviewed	review	VERB
bam-4803	131	23	in	in	ADP
bam-4803	131	24	65	65	NUM
bam-4803	131	25	)	)	PUNCT
bam-4803	131	26	.	.	PUNCT
bam-4803	132	1	however	however	ADV
bam-4803	132	2	,	,	PUNCT
bam-4803	132	3	in	in	ADP
bam-4803	132	4	the	the	DET
bam-4803	132	5	presence	presence	NOUN
bam-4803	132	6	of	of	ADP
bam-4803	132	7	carbon	carbon	NOUN
bam-4803	132	8	supporting	support	VERB
bam-4803	132	9	film	film	NOUN
bam-4803	132	10	,	,	PUNCT
bam-4803	132	11	the	the	DET
bam-4803	132	12	ryr1	ryr1	NOUN
bam-4803	132	13	channel	channel	NOUN
bam-4803	132	14	particles	particle	NOUN
bam-4803	132	15	exhibit	exhibit	VERB
bam-4803	132	16	a	a	DET
bam-4803	132	17	strong	strong	ADJ
bam-4803	132	18	preferred	preferred	ADJ
bam-4803	132	19	orientation	orientation	NOUN
bam-4803	132	20	with	with	ADP
bam-4803	132	21	a	a	DET
bam-4803	132	22	majority	majority	NOUN
bam-4803	132	23	of	of	ADP
bam-4803	132	24	particles	particle	NOUN
bam-4803	132	25	appearing	appear	VERB
bam-4803	132	26	along	along	ADP
bam-4803	132	27	the	the	DET
bam-4803	132	28	four	four	NUM
bam-4803	132	29	-	-	ADJ
bam-4803	132	30	fold	fold	ADJ
bam-4803	132	31	channel	channel	NOUN
bam-4803	132	32	axis	axis	NOUN
bam-4803	132	33	.	.	PUNCT
bam-4803	133	1	while	while	SCONJ
bam-4803	133	2	oblique	oblique	ADJ
bam-4803	133	3	views	view	NOUN
bam-4803	133	4	are	be	AUX
bam-4803	133	5	certainly	certainly	ADV
bam-4803	133	6	present	present	ADJ
bam-4803	133	7	within	within	ADP
bam-4803	133	8	the	the	DET
bam-4803	133	9	cryospecimen	cryospeciman	NOUN
bam-4803	133	10	and	and	CCONJ
bam-4803	133	11	can	can	AUX
bam-4803	133	12	be	be	AUX
bam-4803	133	13	retrieved	retrieve	VERB
bam-4803	133	14	via	via	ADP
bam-4803	133	15	iterative	iterative	ADJ
bam-4803	133	16	image	image	NOUN
bam-4803	133	17	processing	processing	NOUN
bam-4803	133	18	procedure	procedure	NOUN
bam-4803	133	19	,	,	PUNCT
bam-4803	133	20	36	36	NUM
bam-4803	133	21	their	their	PRON
bam-4803	133	22	presence	presence	NOUN
bam-4803	133	23	is	be	AUX
bam-4803	133	24	highly	highly	ADV
bam-4803	133	25	variable	variable	ADJ
bam-4803	133	26	and	and	CCONJ
bam-4803	133	27	specimen	speciman	NOUN
bam-4803	133	28	dependent	dependent	ADJ
bam-4803	133	29	.	.	PUNCT
bam-4803	134	1	it	it	PRON
bam-4803	134	2	requires	require	VERB
bam-4803	134	3	a	a	DET
bam-4803	134	4	collection	collection	NOUN
bam-4803	134	5	of	of	ADP
bam-4803	134	6	substantially	substantially	ADV
bam-4803	134	7	larger	large	ADJ
bam-4803	134	8	data	datum	NOUN
bam-4803	134	9	sets	set	NOUN
bam-4803	134	10	to	to	PART
bam-4803	134	11	bring	bring	VERB
bam-4803	134	12	these	these	DET
bam-4803	134	13	oblique	oblique	ADJ
bam-4803	134	14	views	view	NOUN
bam-4803	134	15	to	to	ADP
bam-4803	134	16	statistical	statistical	ADJ
bam-4803	134	17	significance	significance	NOUN
bam-4803	134	18	in	in	ADP
bam-4803	134	19	order	order	NOUN
bam-4803	134	20	to	to	PART
bam-4803	134	21	achieve	achieve	VERB
bam-4803	134	22	reliable	reliable	ADJ
bam-4803	134	23	isotropic	isotropic	NOUN
bam-4803	134	24	reconstruction	reconstruction	NOUN
bam-4803	134	25	of	of	ADP
bam-4803	134	26	ryr	ryr	NOUN
bam-4803	134	27	channels	channel	NOUN
bam-4803	134	28	.	.	PUNCT
bam-4803	135	1	another	another	DET
bam-4803	135	2	difficulty	difficulty	NOUN
bam-4803	135	3	in	in	ADP
bam-4803	135	4	cryo	cryo	NOUN
bam-4803	135	5	-	-	PUNCT
bam-4803	135	6	em	em	PRON
bam-4803	135	7	study	study	NOUN
bam-4803	135	8	of	of	ADP
bam-4803	135	9	membrane	membrane	NOUN
bam-4803	135	10	proteins	protein	NOUN
bam-4803	135	11	is	be	AUX
bam-4803	135	12	that	that	SCONJ
bam-4803	135	13	the	the	DET
bam-4803	135	14	presence	presence	NOUN
bam-4803	135	15	of	of	ADP
bam-4803	135	16	detergent	detergent	NOUN
bam-4803	135	17	in	in	ADP
bam-4803	135	18	the	the	DET
bam-4803	135	19	cryospecimen	cryospeciman	NOUN
bam-4803	135	20	substantially	substantially	ADV
bam-4803	135	21	reduces	reduce	VERB
bam-4803	135	22	signal	signal	NOUN
bam-4803	135	23	to	to	PART
bam-4803	135	24	noise	noise	VERB
bam-4803	135	25	ratio	ratio	NOUN
bam-4803	135	26	in	in	ADP
bam-4803	135	27	em	em	PRON
bam-4803	135	28	images	image	NOUN
bam-4803	135	29	,	,	PUNCT
bam-4803	135	30	which	which	PRON
bam-4803	135	31	is	be	AUX
bam-4803	135	32	already	already	ADV
bam-4803	135	33	considered	consider	VERB
bam-4803	135	34	very	very	ADV
bam-4803	135	35	low	low	ADJ
bam-4803	135	36	for	for	ADP
bam-4803	135	37	single	single	ADJ
bam-4803	135	38	-	-	PUNCT
bam-4803	135	39	particle	particle	NOUN
bam-4803	135	40	studies	study	NOUN
bam-4803	135	41	.	.	PUNCT
bam-4803	136	1	this	this	DET
bam-4803	136	2	effect	effect	NOUN
bam-4803	136	3	is	be	AUX
bam-4803	136	4	particularly	particularly	ADV
bam-4803	136	5	disastrous	disastrous	ADJ
bam-4803	136	6	for	for	ADP
bam-4803	136	7	the	the	DET
bam-4803	136	8	high	high	ADJ
bam-4803	136	9	-	-	PUNCT
bam-4803	136	10	resolution	resolution	NOUN
bam-4803	136	11	signal	signal	NOUN
bam-4803	136	12	where	where	SCONJ
bam-4803	136	13	contrast	contrast	NOUN
bam-4803	136	14	is	be	AUX
bam-4803	136	15	marginal	marginal	ADJ
bam-4803	136	16	even	even	ADV
bam-4803	136	17	without	without	ADP
bam-4803	136	18	detergent	detergent	NOUN
bam-4803	136	19	.	.	PUNCT
bam-4803	137	1	for	for	ADP
bam-4803	137	2	optimal	optimal	ADJ
bam-4803	137	3	stability	stability	NOUN
bam-4803	137	4	of	of	ADP
bam-4803	137	5	protein	protein	NOUN
bam-4803	137	6	-	-	PUNCT
bam-4803	137	7	detergent	detergent	NOUN
bam-4803	137	8	complexes	complex	NOUN
bam-4803	137	9	,	,	PUNCT
bam-4803	137	10	detergent	detergent	NOUN
bam-4803	137	11	concentrations	concentration	NOUN
bam-4803	137	12	are	be	AUX
bam-4803	137	13	kept	keep	VERB
bam-4803	137	14	near	near	ADP
bam-4803	137	15	or	or	CCONJ
bam-4803	137	16	above	above	ADP
bam-4803	137	17	the	the	DET
bam-4803	137	18	critical	critical	ADJ
bam-4803	137	19	micelle	micelle	NOUN
bam-4803	137	20	-	-	PUNCT
bam-4803	137	21	forming	form	VERB
bam-4803	137	22	concentration	concentration	NOUN
bam-4803	137	23	(	(	PUNCT
bam-4803	137	24	cmc	cmc	NOUN
bam-4803	137	25	)	)	PUNCT
bam-4803	137	26	,	,	PUNCT
bam-4803	137	27	meaning	mean	VERB
bam-4803	137	28	the	the	DET
bam-4803	137	29	buffer	buffer	NOUN
bam-4803	137	30	is	be	AUX
bam-4803	137	31	nearly	nearly	ADV
bam-4803	137	32	saturated	saturate	VERB
bam-4803	137	33	with	with	ADP
bam-4803	137	34	detergent	detergent	NOUN
bam-4803	137	35	molecules	molecule	NOUN
bam-4803	137	36	,	,	PUNCT
bam-4803	137	37	which	which	PRON
bam-4803	137	38	produces	produce	VERB
bam-4803	137	39	a	a	DET
bam-4803	137	40	tremendous	tremendous	ADJ
bam-4803	137	41	level	level	NOUN
bam-4803	137	42	of	of	ADP
bam-4803	137	43	‘	'	PUNCT
bam-4803	137	44	noise	noise	NOUN
bam-4803	137	45	’	'	PUNCT
bam-4803	137	46	in	in	ADP
bam-4803	137	47	cryo	cryo	NOUN
bam-4803	137	48	-	-	PUNCT
bam-4803	137	49	em	em	PRON
bam-4803	137	50	images	image	NOUN
bam-4803	137	51	and	and	CCONJ
bam-4803	137	52	can	can	AUX
bam-4803	137	53	reduce	reduce	VERB
bam-4803	137	54	image	image	NOUN
bam-4803	137	55	contrast	contrast	NOUN
bam-4803	137	56	.	.	PUNCT
bam-4803	138	1	this	this	PRON
bam-4803	138	2	is	be	AUX
bam-4803	138	3	by	by	ADP
bam-4803	138	4	far	far	ADV
bam-4803	138	5	a	a	DET
bam-4803	138	6	limiting	limit	VERB
bam-4803	138	7	aspect	aspect	NOUN
bam-4803	138	8	of	of	ADP
bam-4803	138	9	cryo	cryo	NOUN
bam-4803	138	10	-	-	PUNCT
bam-4803	138	11	em	em	PRON
bam-4803	138	12	visualization	visualization	NOUN
bam-4803	138	13	of	of	ADP
bam-4803	138	14	membrane	membrane	ADJ
bam-4803	138	15	proteins	protein	NOUN
bam-4803	138	16	in	in	ADP
bam-4803	138	17	detergent	detergent	NOUN
bam-4803	138	18	.	.	PUNCT
bam-4803	139	1	this	this	DET
bam-4803	139	2	point	point	NOUN
bam-4803	139	3	has	have	AUX
bam-4803	139	4	not	not	PART
bam-4803	139	5	been	be	AUX
bam-4803	139	6	widely	widely	ADV
bam-4803	139	7	understood	understand	VERB
bam-4803	139	8	in	in	ADP
bam-4803	139	9	the	the	DET
bam-4803	139	10	cryo	cryo	NOUN
bam-4803	139	11	-	-	PUNCT
bam-4803	139	12	em	em	PROPN
bam-4803	139	13	community	community	NOUN
bam-4803	139	14	since	since	SCONJ
bam-4803	139	15	the	the	DET
bam-4803	139	16	detergent	detergent	NOUN
bam-4803	139	17	also	also	ADV
bam-4803	139	18	produces	produce	VERB
bam-4803	139	19	very	very	ADV
bam-4803	139	20	strong	strong	ADJ
bam-4803	139	21	thon	thon	PROPN
bam-4803	139	22	rings	ring	NOUN
bam-4803	139	23	,	,	PUNCT
bam-4803	139	24	giving	give	VERB
bam-4803	139	25	such	such	ADJ
bam-4803	139	26	images	image	NOUN
bam-4803	139	27	an	an	DET
bam-4803	139	28	appearance	appearance	NOUN
bam-4803	139	29	of	of	ADP
bam-4803	139	30	very	very	ADV
bam-4803	139	31	good	good	ADJ
bam-4803	139	32	quality	quality	NOUN
bam-4803	139	33	when	when	SCONJ
bam-4803	139	34	judged	judge	VERB
bam-4803	139	35	by	by	ADP
bam-4803	139	36	its	its	PRON
bam-4803	139	37	power	power	NOUN
bam-4803	139	38	spectrum	spectrum	NOUN
bam-4803	139	39	.	.	PUNCT
bam-4803	140	1	while	while	SCONJ
bam-4803	140	2	there	there	PRON
bam-4803	140	3	is	be	VERB
bam-4803	140	4	no	no	DET
bam-4803	140	5	accepted	accept	VERB
bam-4803	140	6	standard	standard	NOUN
bam-4803	140	7	for	for	ADP
bam-4803	140	8	assessing	assess	VERB
bam-4803	140	9	a	a	DET
bam-4803	140	10	minimal	minimal	ADJ
bam-4803	140	11	acceptable	acceptable	ADJ
bam-4803	140	12	contrast	contrast	NOUN
bam-4803	140	13	level	level	NOUN
bam-4803	140	14	in	in	ADP
bam-4803	140	15	the	the	DET
bam-4803	140	16	raw	raw	ADJ
bam-4803	140	17	cryo	cryo	NOUN
bam-4803	140	18	-	-	PUNCT
bam-4803	140	19	em	em	PRON
bam-4803	140	20	images	image	NOUN
bam-4803	140	21	,	,	PUNCT
bam-4803	140	22	it	it	PRON
bam-4803	140	23	is	be	AUX
bam-4803	140	24	evident	evident	ADJ
bam-4803	140	25	that	that	SCONJ
bam-4803	140	26	as	as	SCONJ
bam-4803	140	27	contrast	contrast	NOUN
bam-4803	140	28	is	be	AUX
bam-4803	140	29	reduced	reduce	VERB
bam-4803	140	30	,	,	PUNCT
bam-4803	140	31	image	image	NOUN
bam-4803	140	32	processing	processing	NOUN
bam-4803	140	33	becomes	become	VERB
bam-4803	140	34	more	more	ADV
bam-4803	140	35	susceptible	susceptible	ADJ
bam-4803	140	36	to	to	ADP
bam-4803	140	37	a	a	DET
bam-4803	140	38	model	model	NOUN
bam-4803	140	39	bias	bias	NOUN
bam-4803	140	40	and	and	CCONJ
bam-4803	140	41	producing	produce	VERB
bam-4803	140	42	a	a	DET
bam-4803	140	43	reliable	reliable	ADJ
bam-4803	140	44	3d	3d	NOUN
bam-4803	140	45	reconstruction	reconstruction	NOUN
bam-4803	140	46	becomes	become	VERB
bam-4803	140	47	problematic	problematic	ADJ
bam-4803	140	48	.	.	PUNCT
bam-4803	141	1	64	64	NUM
bam-4803	141	2	clearly	clearly	ADV
bam-4803	141	3	,	,	PUNCT
bam-4803	141	4	the	the	DET
bam-4803	141	5	physical	physical	ADJ
bam-4803	141	6	behavior	behavior	NOUN
bam-4803	141	7	of	of	ADP
bam-4803	141	8	detergents	detergent	NOUN
bam-4803	141	9	and	and	CCONJ
bam-4803	141	10	properties	property	NOUN
bam-4803	141	11	of	of	ADP
bam-4803	141	12	protein	protein	NOUN
bam-4803	141	13	-	-	PUNCT
bam-4803	141	14	detergent	detergent	NOUN
bam-4803	141	15	complexes	complex	NOUN
bam-4803	141	16	must	must	AUX
bam-4803	141	17	be	be	AUX
bam-4803	141	18	considered	consider	VERB
bam-4803	141	19	and	and	CCONJ
bam-4803	141	20	controlled	control	VERB
bam-4803	141	21	during	during	ADP
bam-4803	141	22	cryo	cryo	NOUN
bam-4803	141	23	-	-	PUNCT
bam-4803	141	24	em	em	PRON
bam-4803	141	25	experiments	experiment	NOUN
bam-4803	141	26	.	.	PUNCT
bam-4803	142	1	however	however	ADV
bam-4803	142	2	,	,	PUNCT
bam-4803	142	3	despite	despite	SCONJ
bam-4803	142	4	the	the	DET
bam-4803	142	5	increasing	increase	VERB
bam-4803	142	6	number	number	NOUN
bam-4803	142	7	of	of	ADP
bam-4803	142	8	structures	structure	NOUN
bam-4803	142	9	of	of	ADP
bam-4803	142	10	membrane	membrane	NOUN
bam-4803	142	11	proteins	protein	NOUN
bam-4803	142	12	solved	solve	VERB
bam-4803	142	13	by	by	ADP
bam-4803	142	14	singleparticle	singleparticle	PROPN
bam-4803	142	15	cryo	cryo	PROPN
bam-4803	142	16	-	-	PUNCT
bam-4803	142	17	em	em	PROPN
bam-4803	142	18	,	,	PUNCT
bam-4803	142	19	ice	ice	NOUN
bam-4803	142	20	-	-	PUNCT
bam-4803	142	21	embedding	embed	VERB
bam-4803	142	22	procedure	procedure	NOUN
bam-4803	142	23	for	for	ADP
bam-4803	142	24	membrane	membrane	NOUN
bam-4803	142	25	proteins	protein	NOUN
bam-4803	142	26	remains	remain	VERB
bam-4803	142	27	most	most	ADV
bam-4803	142	28	difficult	difficult	ADJ
bam-4803	142	29	due	due	ADP
bam-4803	142	30	to	to	ADP
bam-4803	142	31	the	the	DET
bam-4803	142	32	lack	lack	NOUN
bam-4803	142	33	straightforward	straightforward	ADJ
bam-4803	142	34	,	,	PUNCT
bam-4803	142	35	reproducible	reproducible	ADJ
bam-4803	142	36	methodologies	methodology	NOUN
bam-4803	142	37	and	and	CCONJ
bam-4803	142	38	strategies	strategy	NOUN
bam-4803	142	39	.	.	PUNCT
bam-4803	143	1	the	the	DET
bam-4803	143	2	choice	choice	NOUN
bam-4803	143	3	of	of	ADP
bam-4803	143	4	the	the	DET
bam-4803	143	5	detergent	detergent	NOUN
bam-4803	143	6	chosen	choose	VERB
bam-4803	143	7	for	for	ADP
bam-4803	143	8	the	the	DET
bam-4803	143	9	disruption	disruption	NOUN
bam-4803	143	10	of	of	ADP
bam-4803	143	11	lipid	lipid	ADJ
bam-4803	143	12	bilayer	bilayer	NOUN
bam-4803	143	13	and	and	CCONJ
bam-4803	143	14	extraction	extraction	NOUN
bam-4803	143	15	of	of	ADP
bam-4803	143	16	the	the	DET
bam-4803	143	17	membrane	membrane	NOUN
bam-4803	143	18	protein	protein	NOUN
bam-4803	143	19	of	of	ADP
bam-4803	143	20	interest	interest	NOUN
bam-4803	143	21	is	be	AUX
bam-4803	143	22	rather	rather	ADV
bam-4803	143	23	more	more	ADV
bam-4803	143	24	empirical	empirical	ADJ
bam-4803	143	25	than	than	ADP
bam-4803	143	26	knowledge	knowledge	NOUN
bam-4803	143	27	-	-	PUNCT
bam-4803	143	28	driven	drive	VERB
bam-4803	143	29	procedure	procedure	NOUN
bam-4803	143	30	.	.	PUNCT
bam-4803	144	1	in	in	ADP
bam-4803	144	2	light	light	NOUN
bam-4803	144	3	of	of	ADP
bam-4803	144	4	the	the	DET
bam-4803	144	5	complexities	complexity	NOUN
bam-4803	144	6	of	of	ADP
bam-4803	144	7	protein	protein	NOUN
bam-4803	144	8	-	-	PUNCT
bam-4803	144	9	detergent	detergent	NOUN
bam-4803	144	10	interactions	interaction	NOUN
bam-4803	144	11	,	,	PUNCT
bam-4803	144	12	it	it	PRON
bam-4803	144	13	is	be	AUX
bam-4803	144	14	important	important	ADJ
bam-4803	144	15	to	to	PART
bam-4803	144	16	preserve	preserve	VERB
bam-4803	144	17	structure	structure	NOUN
bam-4803	144	18	and	and	CCONJ
bam-4803	144	19	function	function	NOUN
bam-4803	144	20	of	of	ADP
bam-4803	144	21	membrane	membrane	NOUN
bam-4803	144	22	proteins	protein	NOUN
bam-4803	144	23	while	while	SCONJ
bam-4803	144	24	maintaining	maintain	VERB
bam-4803	144	25	their	their	PRON
bam-4803	144	26	solubility	solubility	NOUN
bam-4803	144	27	.	.	PUNCT
bam-4803	145	1	single	single	ADJ
bam-4803	145	2	-	-	PUNCT
bam-4803	145	3	particle	particle	NOUN
bam-4803	145	4	cryo	cryo	NOUN
bam-4803	145	5	-	-	PUNCT
bam-4803	145	6	em	em	PRON
bam-4803	145	7	of	of	ADP
bam-4803	145	8	the	the	DET
bam-4803	145	9	ryanodine	ryanodine	PROPN
bam-4803	145	10	receptor	receptor	NOUN
bam-4803	145	11	channel	channel	PROPN
bam-4803	145	12	eur	eur	PROPN
bam-4803	145	13	j	j	PROPN
bam-4803	145	14	transl	transl	PROPN
bam-4803	145	15	myol	myol	PROPN
bam-4803	145	16	basic	basic	ADJ
bam-4803	145	17	appl	appl	NOUN
bam-4803	145	18	myol	myol	NOUN
bam-4803	145	19	2015	2015	NUM
bam-4803	145	20	;	;	PUNCT
bam-4803	145	21	25	25	NUM
bam-4803	145	22	(	(	PUNCT
bam-4803	145	23	1	1	NUM
bam-4803	145	24	):	):	PUNCT
bam-4803	145	25	35	35	NUM
bam-4803	145	26	-	-	SYM
bam-4803	145	27	48	48	NUM
bam-4803	145	28	41	41	NUM
bam-4803	145	29	however	however	ADV
bam-4803	145	30	,	,	PUNCT
bam-4803	145	31	no	no	DET
bam-4803	145	32	‘	'	PUNCT
bam-4803	145	33	magic	magic	ADJ
bam-4803	145	34	bullet	bullet	NOUN
bam-4803	145	35	’	'	PUNCT
bam-4803	145	36	detergent	detergent	NOUN
bam-4803	145	37	exists	exist	VERB
bam-4803	145	38	for	for	ADP
bam-4803	145	39	handling	handle	VERB
bam-4803	145	40	all	all	DET
bam-4803	145	41	membrane	membrane	ADJ
bam-4803	145	42	proteins	protein	NOUN
bam-4803	145	43	in	in	ADP
bam-4803	145	44	a	a	DET
bam-4803	145	45	manner	manner	NOUN
bam-4803	145	46	suitable	suitable	ADJ
bam-4803	145	47	for	for	ADP
bam-4803	145	48	single	single	ADJ
bam-4803	145	49	-	-	PUNCT
bam-4803	145	50	particle	particle	NOUN
bam-4803	145	51	cryo	cryo	NOUN
bam-4803	145	52	-	-	PUNCT
bam-4803	145	53	em	em	PRON
bam-4803	145	54	experiments	experiment	NOUN
bam-4803	145	55	,	,	PUNCT
bam-4803	145	56	and	and	CCONJ
bam-4803	145	57	often	often	ADV
bam-4803	145	58	trial	trial	NOUN
bam-4803	145	59	-	-	PUNCT
bam-4803	145	60	and	and	CCONJ
bam-4803	145	61	-	-	PUNCT
bam-4803	145	62	error	error	NOUN
bam-4803	145	63	is	be	AUX
bam-4803	145	64	the	the	DET
bam-4803	145	65	only	only	ADJ
bam-4803	145	66	way	way	NOUN
bam-4803	145	67	to	to	PART
bam-4803	145	68	tell	tell	VERB
bam-4803	145	69	.	.	PUNCT
bam-4803	146	1	examples	example	NOUN
bam-4803	146	2	of	of	ADP
bam-4803	146	3	successful	successful	ADJ
bam-4803	146	4	single	single	ADJ
bam-4803	146	5	-	-	PUNCT
bam-4803	146	6	particle	particle	NOUN
bam-4803	146	7	em	em	PRON
bam-4803	146	8	studies	study	NOUN
bam-4803	146	9	of	of	ADP
bam-4803	146	10	ion	ion	NOUN
bam-4803	146	11	channels	channel	NOUN
bam-4803	146	12	and	and	CCONJ
bam-4803	146	13	some	some	DET
bam-4803	146	14	other	other	ADJ
bam-4803	146	15	integral	integral	ADJ
bam-4803	146	16	membrane	membrane	NOUN
bam-4803	146	17	proteins	protein	NOUN
bam-4803	146	18	are	be	AUX
bam-4803	146	19	given	give	VERB
bam-4803	146	20	in	in	ADP
bam-4803	146	21	table	table	NOUN
bam-4803	146	22	1	1	NUM
bam-4803	146	23	.	.	PUNCT
bam-4803	147	1	despite	despite	SCONJ
bam-4803	147	2	the	the	DET
bam-4803	147	3	fact	fact	NOUN
bam-4803	147	4	that	that	SCONJ
bam-4803	147	5	critical	critical	ADJ
bam-4803	147	6	information	information	NOUN
bam-4803	147	7	on	on	ADP
bam-4803	147	8	vitrification	vitrification	NOUN
bam-4803	147	9	of	of	ADP
bam-4803	147	10	membrane	membrane	ADJ
bam-4803	147	11	proteins	protein	NOUN
bam-4803	147	12	is	be	AUX
bam-4803	147	13	unpublished	unpublished	ADJ
bam-4803	147	14	,	,	PUNCT
bam-4803	147	15	bits	bit	NOUN
bam-4803	147	16	of	of	ADP
bam-4803	147	17	lore	lore	NOUN
bam-4803	147	18	can	can	AUX
bam-4803	147	19	be	be	AUX
bam-4803	147	20	extracted	extract	VERB
bam-4803	147	21	from	from	ADP
bam-4803	147	22	these	these	DET
bam-4803	147	23	studies	study	NOUN
bam-4803	147	24	to	to	PART
bam-4803	147	25	rationalize	rationalize	VERB
bam-4803	147	26	cryo	cryo	PROPN
bam-4803	147	27	-	-	PUNCT
bam-4803	147	28	em	em	PRON
bam-4803	147	29	experiments	experiment	NOUN
bam-4803	147	30	with	with	ADP
bam-4803	147	31	membrane	membrane	ADJ
bam-4803	147	32	proteins	protein	NOUN
bam-4803	147	33	.	.	PUNCT
bam-4803	148	1	the	the	DET
bam-4803	148	2	general	general	ADJ
bam-4803	148	3	conclusion	conclusion	NOUN
bam-4803	148	4	is	be	AUX
bam-4803	148	5	that	that	SCONJ
bam-4803	148	6	detergents	detergent	NOUN
bam-4803	148	7	with	with	ADP
bam-4803	148	8	low	low	ADJ
bam-4803	148	9	cmc	cmc	NOUN
bam-4803	148	10	and	and	CCONJ
bam-4803	148	11	high	high	ADJ
bam-4803	148	12	aggregation	aggregation	NOUN
bam-4803	148	13	number	number	NOUN
bam-4803	148	14	are	be	AUX
bam-4803	148	15	often	often	ADV
bam-4803	148	16	not	not	PART
bam-4803	148	17	compatible	compatible	ADJ
bam-4803	148	18	with	with	ADP
bam-4803	148	19	single	single	ADJ
bam-4803	148	20	-	-	PUNCT
bam-4803	148	21	particle	particle	NOUN
bam-4803	148	22	cryo	cryo	NOUN
bam-4803	148	23	-	-	PUNCT
bam-4803	148	24	em	em	PROPN
bam-4803	148	25	(	(	PUNCT
bam-4803	148	26	table	table	NOUN
bam-4803	148	27	2	2	NUM
bam-4803	148	28	)	)	PUNCT
bam-4803	148	29	.	.	PUNCT
bam-4803	149	1	through	through	ADP
bam-4803	149	2	our	our	PRON
bam-4803	149	3	experiences	experience	NOUN
bam-4803	149	4	with	with	ADP
bam-4803	149	5	membrane	membrane	NOUN
bam-4803	149	6	proteins	protein	NOUN
bam-4803	149	7	and	and	CCONJ
bam-4803	149	8	cryo	cryo	NOUN
bam-4803	149	9	-	-	PUNCT
bam-4803	149	10	em	em	PRON
bam-4803	149	11	we	we	PRON
bam-4803	149	12	found	find	VERB
bam-4803	149	13	that	that	SCONJ
bam-4803	149	14	single	single	ADJ
bam-4803	149	15	-	-	PUNCT
bam-4803	149	16	particle	particle	NOUN
bam-4803	149	17	cryo	cryo	NOUN
bam-4803	149	18	-	-	PUNCT
bam-4803	149	19	em	em	PRON
bam-4803	149	20	experiment	experiment	NOUN
bam-4803	149	21	should	should	AUX
bam-4803	149	22	be	be	AUX
bam-4803	149	23	performed	perform	VERB
bam-4803	149	24	at	at	ADP
bam-4803	149	25	or	or	CCONJ
bam-4803	149	26	just	just	ADV
bam-4803	149	27	below	below	ADP
bam-4803	149	28	cmc	cmc	NOUN
bam-4803	149	29	to	to	PART
bam-4803	149	30	improve	improve	VERB
bam-4803	149	31	adhesion	adhesion	NOUN
bam-4803	149	32	of	of	ADP
bam-4803	149	33	membrane	membrane	NOUN
bam-4803	149	34	protein	protein	NOUN
bam-4803	149	35	particles	particle	NOUN
bam-4803	149	36	within	within	ADP
bam-4803	149	37	a	a	DET
bam-4803	149	38	layer	layer	NOUN
bam-4803	149	39	of	of	ADP
bam-4803	149	40	vitreous	vitreous	ADJ
bam-4803	149	41	ice	ice	NOUN
bam-4803	149	42	on	on	ADP
bam-4803	149	43	the	the	DET
bam-4803	149	44	em	em	PROPN
bam-4803	149	45	grid	grid	NOUN
bam-4803	149	46	yet	yet	ADV
bam-4803	149	47	maintain	maintain	VERB
bam-4803	149	48	a	a	DET
bam-4803	149	49	soluble	soluble	ADJ
bam-4803	149	50	membrane	membrane	NOUN
bam-4803	149	51	protein	protein	NOUN
bam-4803	149	52	.	.	PUNCT
bam-4803	150	1	having	have	VERB
bam-4803	150	2	too	too	ADV
bam-4803	150	3	little	little	ADJ
bam-4803	150	4	detergent	detergent	NOUN
bam-4803	150	5	in	in	ADP
bam-4803	150	6	solution	solution	NOUN
bam-4803	150	7	can	can	AUX
bam-4803	150	8	shift	shift	VERB
bam-4803	150	9	the	the	DET
bam-4803	150	10	equilibrium	equilibrium	NOUN
bam-4803	150	11	to	to	PART
bam-4803	150	12	favor	favor	VERB
bam-4803	150	13	detergent	detergent	NOUN
bam-4803	150	14	monomers	monomer	NOUN
bam-4803	150	15	over	over	ADP
bam-4803	150	16	micelles	micelle	NOUN
bam-4803	150	17	,	,	PUNCT
bam-4803	150	18	leading	lead	VERB
bam-4803	150	19	to	to	ADP
bam-4803	150	20	unprotected	unprotected	ADJ
bam-4803	150	21	transmembrane	transmembrane	NOUN
bam-4803	150	22	domains	domain	NOUN
bam-4803	150	23	and	and	CCONJ
bam-4803	150	24	protein	protein	NOUN
bam-4803	150	25	aggregation	aggregation	NOUN
bam-4803	150	26	while	while	NOUN
bam-4803	150	27	,	,	PUNCT
bam-4803	150	28	too	too	ADV
bam-4803	150	29	much	much	ADJ
bam-4803	150	30	detergent	detergent	NOUN
bam-4803	150	31	may	may	AUX
bam-4803	150	32	dissociate	dissociate	VERB
bam-4803	150	33	some	some	DET
bam-4803	150	34	stabilizing	stabilizing	NOUN
bam-4803	150	35	lipids	lipid	NOUN
bam-4803	150	36	required	require	VERB
bam-4803	150	37	to	to	PART
bam-4803	150	38	maintain	maintain	VERB
bam-4803	150	39	the	the	DET
bam-4803	150	40	protein	protein	NOUN
bam-4803	150	41	’s	’s	PART
bam-4803	150	42	structure	structure	NOUN
bam-4803	150	43	and	and	CCONJ
bam-4803	150	44	affect	affect	VERB
bam-4803	150	45	ice	ice	NOUN
bam-4803	150	46	-	-	PUNCT
bam-4803	150	47	embedding	embed	VERB
bam-4803	150	48	procedure	procedure	NOUN
bam-4803	150	49	.	.	PUNCT
bam-4803	151	1	overall	overall	ADJ
bam-4803	151	2	,	,	PUNCT
bam-4803	151	3	selection	selection	NOUN
bam-4803	151	4	of	of	ADP
bam-4803	151	5	the	the	DET
bam-4803	151	6	appropriate	appropriate	ADJ
bam-4803	151	7	detergent	detergent	NOUN
bam-4803	151	8	for	for	ADP
bam-4803	151	9	the	the	DET
bam-4803	151	10	study	study	NOUN
bam-4803	151	11	of	of	ADP
bam-4803	151	12	membrane	membrane	NOUN
bam-4803	151	13	protein	protein	NOUN
bam-4803	151	14	by	by	ADP
bam-4803	151	15	single	single	ADJ
bam-4803	151	16	-	-	PUNCT
bam-4803	151	17	particle	particle	NOUN
bam-4803	151	18	cryo	cryo	NOUN
bam-4803	151	19	-	-	PUNCT
bam-4803	151	20	em	em	PRON
bam-4803	151	21	requires	require	VERB
bam-4803	151	22	the	the	DET
bam-4803	151	23	consideration	consideration	NOUN
bam-4803	151	24	of	of	ADP
bam-4803	151	25	how	how	SCONJ
bam-4803	151	26	it	it	PRON
bam-4803	151	27	will	will	AUX
bam-4803	151	28	impact	impact	VERB
bam-4803	151	29	the	the	DET
bam-4803	151	30	protein	protein	NOUN
bam-4803	151	31	activity	activity	NOUN
bam-4803	151	32	,	,	PUNCT
bam-4803	151	33	quaternary	quaternary	ADJ
bam-4803	151	34	structure	structure	NOUN
bam-4803	151	35	and	and	CCONJ
bam-4803	151	36	its	its	PRON
bam-4803	151	37	propensity	propensity	NOUN
bam-4803	151	38	for	for	ADP
bam-4803	151	39	vitrification	vitrification	NOUN
bam-4803	151	40	.	.	PUNCT
bam-4803	152	1	the	the	DET
bam-4803	152	2	limited	limited	ADJ
bam-4803	152	3	current	current	ADJ
bam-4803	152	4	understanding	understanding	NOUN
bam-4803	152	5	of	of	ADP
bam-4803	152	6	protein	protein	NOUN
bam-4803	152	7	/	/	SYM
bam-4803	152	8	detergent	detergent	NOUN
bam-4803	152	9	systems	system	NOUN
bam-4803	152	10	and	and	CCONJ
bam-4803	152	11	forces	force	NOUN
bam-4803	152	12	that	that	PRON
bam-4803	152	13	maintain	maintain	VERB
bam-4803	152	14	the	the	DET
bam-4803	152	15	sample	sample	NOUN
bam-4803	152	16	in	in	ADP
bam-4803	152	17	a	a	DET
bam-4803	152	18	vitreous	vitreous	ADJ
bam-4803	152	19	ice	ice	NOUN
bam-4803	152	20	have	have	VERB
bam-4803	152	21	frustrated	frustrate	VERB
bam-4803	152	22	efforts	effort	NOUN
bam-4803	152	23	of	of	ADP
bam-4803	152	24	many	many	ADJ
bam-4803	152	25	researches	research	NOUN
bam-4803	152	26	to	to	PART
bam-4803	152	27	exploit	exploit	VERB
bam-4803	152	28	the	the	DET
bam-4803	152	29	structure	structure	NOUN
bam-4803	152	30	of	of	ADP
bam-4803	152	31	membrane	membrane	ADJ
bam-4803	152	32	proteins	protein	NOUN
bam-4803	152	33	using	use	VERB
bam-4803	152	34	single	single	ADJ
bam-4803	152	35	-	-	PUNCT
bam-4803	152	36	particle	particle	NOUN
bam-4803	152	37	cryo	cryo	NOUN
bam-4803	152	38	-	-	PUNCT
bam-4803	152	39	em	em	PRON
bam-4803	152	40	and	and	CCONJ
bam-4803	152	41	stimulated	stimulate	VERB
bam-4803	152	42	the	the	DET
bam-4803	152	43	developments	development	NOUN
bam-4803	152	44	of	of	ADP
bam-4803	152	45	approaches	approach	NOUN
bam-4803	152	46	to	to	PART
bam-4803	152	47	transfer	transfer	VERB
bam-4803	152	48	membrane	membrane	NOUN
bam-4803	152	49	proteins	protein	NOUN
bam-4803	152	50	to	to	ADP
bam-4803	152	51	a	a	DET
bam-4803	152	52	more	more	ADV
bam-4803	152	53	tractable	tractable	ADJ
bam-4803	152	54	environment	environment	NOUN
bam-4803	152	55	that	that	PRON
bam-4803	152	56	would	would	AUX
bam-4803	152	57	satisfy	satisfy	VERB
bam-4803	152	58	the	the	DET
bam-4803	152	59	hydrophobic	hydrophobic	NOUN
bam-4803	152	60	nature	nature	NOUN
bam-4803	152	61	of	of	ADP
bam-4803	152	62	the	the	DET
bam-4803	152	63	transmembrane	transmembrane	NOUN
bam-4803	152	64	domains	domain	NOUN
bam-4803	152	65	and	and	CCONJ
bam-4803	152	66	allow	allow	VERB
bam-4803	152	67	for	for	ADP
bam-4803	152	68	reproducible	reproducible	ADJ
bam-4803	152	69	successful	successful	ADJ
bam-4803	152	70	vitrification	vitrification	NOUN
bam-4803	152	71	.	.	PUNCT
bam-4803	153	1	5,66	5,66	NUM
bam-4803	153	2	-	-	SYM
bam-4803	153	3	68	68	NUM
bam-4803	153	4	alternatives	alternative	NOUN
bam-4803	153	5	to	to	ADP
bam-4803	153	6	maintaining	maintain	VERB
bam-4803	153	7	membrane	membrane	ADJ
bam-4803	153	8	proteins	protein	NOUN
bam-4803	153	9	in	in	ADP
bam-4803	153	10	non	non	ADJ
bam-4803	153	11	-	-	ADJ
bam-4803	153	12	detergent	detergent	ADJ
bam-4803	153	13	aqueous	aqueous	ADJ
bam-4803	153	14	solutions	solution	NOUN
bam-4803	153	15	,	,	PUNCT
bam-4803	153	16	like	like	ADP
bam-4803	153	17	amphipols	amphipol	NOUN
bam-4803	153	18	,	,	PUNCT
bam-4803	153	19	have	have	AUX
bam-4803	153	20	begun	begin	VERB
bam-4803	153	21	to	to	PART
bam-4803	153	22	prove	prove	VERB
bam-4803	153	23	useful	useful	ADJ
bam-4803	153	24	in	in	ADP
bam-4803	153	25	cryoem	cryoem	NOUN
bam-4803	153	26	.	.	PUNCT
bam-4803	154	1	imaging	imaging	NOUN
bam-4803	154	2	of	of	ADP
bam-4803	154	3	membrane	membrane	ADJ
bam-4803	154	4	proteins	protein	NOUN
bam-4803	154	5	in	in	ADP
bam-4803	154	6	detergent	detergent	NOUN
bam-4803	154	7	-	-	PUNCT
bam-4803	154	8	free	free	ADJ
bam-4803	154	9	aqueous	aqueous	ADJ
bam-4803	154	10	solution	solution	NOUN
bam-4803	154	11	to	to	PART
bam-4803	154	12	circumvent	circumvent	VERB
bam-4803	154	13	detergent	detergent	NOUN
bam-4803	154	14	-	-	PUNCT
bam-4803	154	15	imposed	impose	VERB
bam-4803	154	16	difficulties	difficulty	NOUN
bam-4803	154	17	in	in	ADP
bam-4803	154	18	singleparticle	singleparticle	PROPN
bam-4803	154	19	cryo	cryo	PROPN
bam-4803	154	20	-	-	PUNCT
bam-4803	154	21	em	em	PRON
bam-4803	154	22	studies	study	NOUN
bam-4803	154	23	of	of	ADP
bam-4803	154	24	membrane	membrane	NOUN
bam-4803	154	25	proteins	protein	NOUN
bam-4803	154	26	,	,	PUNCT
bam-4803	154	27	amphipols	amphipol	NOUN
bam-4803	154	28	(	(	PUNCT
bam-4803	154	29	apols	apol	NOUN
bam-4803	154	30	)	)	PUNCT
bam-4803	154	31	have	have	AUX
bam-4803	154	32	recently	recently	ADV
bam-4803	154	33	been	be	AUX
bam-4803	154	34	adopted	adopt	VERB
bam-4803	154	35	in	in	ADP
bam-4803	154	36	cryospecimen	cryospeciman	NOUN
bam-4803	154	37	preparation	preparation	NOUN
bam-4803	154	38	with	with	ADP
bam-4803	154	39	much	much	ADJ
bam-4803	154	40	success	success	NOUN
bam-4803	154	41	.	.	PUNCT
bam-4803	155	1	cryoem	cryoem	NOUN
bam-4803	155	2	structures	structure	NOUN
bam-4803	155	3	of	of	ADP
bam-4803	155	4	apol	apol	NOUN
bam-4803	155	5	bound	bind	VERB
bam-4803	155	6	trpv1	trpv1	NOUN
bam-4803	155	7	channel	channel	NOUN
bam-4803	155	8	and	and	CCONJ
bam-4803	155	9	secretase	secretase	PUNCT
bam-4803	155	10	complex	complex	NOUN
bam-4803	155	11	were	be	AUX
bam-4803	155	12	solved	solve	VERB
bam-4803	155	13	at	at	ADP
bam-4803	155	14	3.4	3.4	NUM
bam-4803	155	15	å	å	NOUN
bam-4803	155	16	and	and	CCONJ
bam-4803	155	17	4.5	4.5	NUM
bam-4803	155	18	å	å	PROPN
bam-4803	155	19	,	,	PUNCT
bam-4803	155	20	respectively	respectively	ADV
bam-4803	155	21	,	,	PUNCT
bam-4803	155	22	resolving	resolve	VERB
bam-4803	155	23	their	their	PRON
bam-4803	155	24	transmembrane	transmembrane	NOUN
bam-4803	155	25	domains	domain	NOUN
bam-4803	155	26	at	at	ADP
bam-4803	155	27	resolutions	resolution	NOUN
bam-4803	155	28	where	where	SCONJ
bam-4803	155	29	the	the	DET
bam-4803	155	30	cryo	cryo	NOUN
bam-4803	155	31	-	-	PUNCT
bam-4803	155	32	em	em	PRON
bam-4803	155	33	density	density	NOUN
bam-4803	155	34	maps	map	NOUN
bam-4803	155	35	served	serve	VERB
bam-4803	155	36	as	as	ADP
bam-4803	155	37	the	the	DET
bam-4803	155	38	basis	basis	NOUN
bam-4803	155	39	for	for	ADP
bam-4803	155	40	generating	generate	VERB
bam-4803	155	41	de	de	X
bam-4803	155	42	novo	novo	NOUN
bam-4803	155	43	molecular	molecular	ADJ
bam-4803	155	44	structures	structure	NOUN
bam-4803	155	45	.	.	PUNCT
bam-4803	156	1	13,14	13,14	NUM
bam-4803	156	2	the	the	DET
bam-4803	156	3	use	use	NOUN
bam-4803	156	4	of	of	ADP
bam-4803	156	5	apols	apol	NOUN
bam-4803	156	6	allows	allow	VERB
bam-4803	156	7	for	for	ADP
bam-4803	156	8	a	a	DET
bam-4803	156	9	detergent	detergent	NOUN
bam-4803	156	10	-	-	PUNCT
bam-4803	156	11	free	free	ADJ
bam-4803	156	12	approach	approach	NOUN
bam-4803	156	13	to	to	PART
bam-4803	156	14	maintain	maintain	VERB
bam-4803	156	15	membrane	membrane	NOUN
bam-4803	156	16	protein	protein	NOUN
bam-4803	156	17	complexes	complex	NOUN
bam-4803	156	18	in	in	ADP
bam-4803	156	19	solution	solution	NOUN
bam-4803	156	20	and	and	CCONJ
bam-4803	156	21	provides	provide	VERB
bam-4803	156	22	several	several	ADJ
bam-4803	156	23	benefits	benefit	NOUN
bam-4803	156	24	for	for	ADP
bam-4803	156	25	attaining	attain	VERB
bam-4803	156	26	high	high	ADJ
bam-4803	156	27	-	-	PUNCT
bam-4803	156	28	resolution	resolution	NOUN
bam-4803	156	29	structures	structure	NOUN
bam-4803	156	30	by	by	ADP
bam-4803	156	31	single	single	ADJ
bam-4803	156	32	-	-	PUNCT
bam-4803	156	33	particle	particle	NOUN
bam-4803	156	34	cryo	cryo	NOUN
bam-4803	156	35	-	-	PUNCT
bam-4803	156	36	em	em	PROPN
bam-4803	156	37	.	.	PROPN
bam-4803	156	38	fig	fig	PROPN
bam-4803	156	39	3	3	NUM
bam-4803	156	40	.	.	PUNCT
bam-4803	157	1	cryo	cryo	NOUN
bam-4803	157	2	-	-	PUNCT
bam-4803	157	3	em	em	PRON
bam-4803	157	4	images	image	NOUN
bam-4803	157	5	of	of	ADP
bam-4803	157	6	ice	ice	NOUN
bam-4803	157	7	-	-	PUNCT
bam-4803	157	8	embedded	embed	VERB
bam-4803	157	9	purified	purified	ADJ
bam-4803	157	10	ryr1	ryr1	NOUN
bam-4803	157	11	:	:	PUNCT
bam-4803	157	12	in	in	ADP
bam-4803	157	13	the	the	DET
bam-4803	157	14	presence	presence	NOUN
bam-4803	157	15	of	of	ADP
bam-4803	157	16	0.4	0.4	NUM
bam-4803	157	17	%	%	NOUN
bam-4803	157	18	chaps	chap	NOUN
bam-4803	157	19	(	(	PUNCT
bam-4803	157	20	a	a	X
bam-4803	157	21	)	)	PUNCT
bam-4803	157	22	in	in	ADP
bam-4803	157	23	the	the	DET
bam-4803	157	24	presence	presence	NOUN
bam-4803	157	25	of	of	ADP
bam-4803	157	26	a835	a835	PROPN
bam-4803	157	27	(	(	PUNCT
bam-4803	157	28	b	b	NOUN
bam-4803	157	29	)	)	PUNCT
bam-4803	157	30	;	;	PUNCT
bam-4803	157	31	in	in	ADP
bam-4803	157	32	the	the	DET
bam-4803	157	33	presence	presence	NOUN
bam-4803	157	34	of	of	ADP
bam-4803	157	35	a8	a8	PROPN
bam-4803	157	36	-	-	PUNCT
bam-4803	157	37	35	35	NUM
bam-4803	157	38	/	/	SYM
bam-4803	157	39	n	n	CCONJ
bam-4803	157	40	-	-	PUNCT
bam-4803	157	41	octyl	octyl	NOUN
bam-4803	157	42	glucoside	glucoside	NOUN
bam-4803	158	1	[	[	X
bam-4803	158	2	og	og	X
bam-4803	158	3	]	]	PUNCT
bam-4803	158	4	.	.	PUNCT
bam-4803	159	1	note	note	VERB
bam-4803	159	2	preferred	preferred	ADJ
bam-4803	159	3	orientation	orientation	NOUN
bam-4803	159	4	of	of	ADP
bam-4803	159	5	ryr1	ryr1	NOUN
bam-4803	159	6	particles	particle	NOUN
bam-4803	159	7	in	in	ADP
bam-4803	159	8	(	(	PUNCT
bam-4803	159	9	b	b	NOUN
bam-4803	159	10	)	)	PUNCT
bam-4803	159	11	,	,	PUNCT
bam-4803	159	12	while	while	SCONJ
bam-4803	159	13	the	the	DET
bam-4803	159	14	particles	particle	NOUN
bam-4803	159	15	are	be	AUX
bam-4803	159	16	randomly	randomly	ADV
bam-4803	159	17	oriented	orient	VERB
bam-4803	159	18	within	within	ADP
bam-4803	159	19	the	the	DET
bam-4803	159	20	vitreous	vitreous	ADJ
bam-4803	159	21	ice	ice	NOUN
bam-4803	159	22	due	due	ADJ
bam-4803	159	23	to	to	PART
bam-4803	159	24	achieved	achieve	VERB
bam-4803	159	25	optimal	optimal	ADJ
bam-4803	159	26	protein	protein	NOUN
bam-4803	159	27	/	/	SYM
bam-4803	159	28	apol835	apol835	PROPN
bam-4803	159	29	/	/	SYM
bam-4803	159	30	og	og	PROPN
bam-4803	159	31	ratio	ratio	NOUN
bam-4803	159	32	in	in	ADP
bam-4803	159	33	the	the	DET
bam-4803	159	34	cryospecimen	cryospeciman	NOUN
bam-4803	159	35	shown	show	VERB
bam-4803	159	36	in	in	ADP
bam-4803	159	37	(	(	PUNCT
bam-4803	159	38	c	c	NOUN
bam-4803	159	39	)	)	PUNCT
bam-4803	159	40	.	.	PUNCT
bam-4803	160	1	images	image	NOUN
bam-4803	160	2	were	be	AUX
bam-4803	160	3	recorded	record	VERB
bam-4803	160	4	on	on	ADP
bam-4803	160	5	a	a	DET
bam-4803	160	6	gatan	gatan	NOUN
bam-4803	160	7	4k	4k	NOUN
bam-4803	160	8	x	x	SYM
bam-4803	160	9	4k	4k	X
bam-4803	160	10	ccd	ccd	PROPN
bam-4803	160	11	camera	camera	NOUN
bam-4803	160	12	using	use	VERB
bam-4803	160	13	jem2010f	jem2010f	PROPN
bam-4803	160	14	cryomicroscope	cryomicroscope	NOUN
bam-4803	160	15	operated	operate	VERB
bam-4803	160	16	under	under	ADP
bam-4803	160	17	minimal	minimal	ADJ
bam-4803	160	18	electron	electron	NOUN
bam-4803	160	19	dose	dose	NOUN
bam-4803	160	20	conditions	condition	NOUN
bam-4803	160	21	(	(	PUNCT
bam-4803	160	22	~20	~20	X
bam-4803	160	23	e	e	X
bam-4803	160	24	-/å	-/å	PROPN
bam-4803	160	25	2	2	NUM
bam-4803	160	26	)	)	PUNCT
bam-4803	160	27	.	.	PUNCT
bam-4803	161	1	scale	scale	NOUN
bam-4803	161	2	bars	bar	NOUN
bam-4803	161	3	are	be	AUX
bam-4803	161	4	500	500	NUM
bam-4803	161	5	å	å	NOUN
bam-4803	161	6	.	.	PUNCT
bam-4803	162	1	single	single	ADJ
bam-4803	162	2	-	-	PUNCT
bam-4803	162	3	particle	particle	NOUN
bam-4803	162	4	cryo	cryo	NOUN
bam-4803	162	5	-	-	PUNCT
bam-4803	162	6	em	em	PRON
bam-4803	162	7	of	of	ADP
bam-4803	162	8	the	the	DET
bam-4803	162	9	ryanodine	ryanodine	PROPN
bam-4803	162	10	receptor	receptor	NOUN
bam-4803	162	11	channel	channel	PROPN
bam-4803	162	12	eur	eur	PROPN
bam-4803	162	13	j	j	PROPN
bam-4803	162	14	transl	transl	PROPN
bam-4803	162	15	myol	myol	PROPN
bam-4803	162	16	basic	basic	ADJ
bam-4803	162	17	appl	appl	NOUN
bam-4803	162	18	myol	myol	NOUN
bam-4803	162	19	2015	2015	NUM
bam-4803	162	20	;	;	PUNCT
bam-4803	162	21	25	25	NUM
bam-4803	162	22	(	(	PUNCT
bam-4803	162	23	1	1	NUM
bam-4803	162	24	):	):	PUNCT
bam-4803	162	25	35	35	NUM
bam-4803	162	26	-	-	SYM
bam-4803	162	27	48	48	NUM
bam-4803	162	28	42	42	NUM
bam-4803	162	29	apols	apol	NOUN
bam-4803	162	30	are	be	AUX
bam-4803	162	31	a	a	DET
bam-4803	162	32	new	new	ADJ
bam-4803	162	33	class	class	NOUN
bam-4803	162	34	of	of	ADP
bam-4803	162	35	amphipathic	amphipathic	ADJ
bam-4803	162	36	polymers	polymer	NOUN
bam-4803	162	37	that	that	PRON
bam-4803	162	38	are	be	AUX
bam-4803	162	39	designed	design	VERB
bam-4803	162	40	to	to	PART
bam-4803	162	41	substitute	substitute	VERB
bam-4803	162	42	for	for	ADP
bam-4803	162	43	detergents	detergent	NOUN
bam-4803	162	44	,	,	PUNCT
bam-4803	162	45	keeping	keep	VERB
bam-4803	162	46	membrane	membrane	NOUN
bam-4803	162	47	protein	protein	NOUN
bam-4803	162	48	complexes	complexe	VERB
bam-4803	162	49	soluble	soluble	ADJ
bam-4803	162	50	and	and	CCONJ
bam-4803	162	51	functional	functional	ADJ
bam-4803	162	52	in	in	ADP
bam-4803	162	53	aqueous	aqueous	ADJ
bam-4803	162	54	solution	solution	NOUN
bam-4803	162	55	.	.	PUNCT
bam-4803	163	1	69	69	NUM
bam-4803	163	2	-	-	SYM
bam-4803	163	3	71	71	NUM
bam-4803	163	4	apols	apol	NOUN
bam-4803	163	5	are	be	AUX
bam-4803	163	6	considered	consider	VERB
bam-4803	163	7	more	more	ADV
bam-4803	163	8	mild	mild	ADJ
bam-4803	163	9	surfactants	surfactant	NOUN
bam-4803	163	10	than	than	ADP
bam-4803	163	11	detergents	detergent	NOUN
bam-4803	163	12	and	and	CCONJ
bam-4803	163	13	exhibit	exhibit	VERB
bam-4803	163	14	a	a	DET
bam-4803	163	15	very	very	ADV
bam-4803	163	16	high	high	ADJ
bam-4803	163	17	affinity	affinity	NOUN
bam-4803	163	18	for	for	ADP
bam-4803	163	19	transmembrane	transmembrane	ADJ
bam-4803	163	20	surfaces	surface	NOUN
bam-4803	163	21	due	due	ADJ
bam-4803	163	22	to	to	ADP
bam-4803	163	23	a	a	DET
bam-4803	163	24	large	large	ADJ
bam-4803	163	25	number	number	NOUN
bam-4803	163	26	of	of	ADP
bam-4803	163	27	hydrophobic	hydrophobic	NOUN
bam-4803	163	28	chains	chain	NOUN
bam-4803	163	29	.	.	PUNCT
bam-4803	164	1	apols	apol	NOUN
bam-4803	164	2	interact	interact	VERB
bam-4803	164	3	noncovalently	noncovalently	ADV
bam-4803	164	4	forming	form	VERB
bam-4803	164	5	a	a	DET
bam-4803	164	6	protective	protective	ADJ
bam-4803	164	7	belt	belt	NOUN
bam-4803	164	8	around	around	ADP
bam-4803	164	9	the	the	DET
bam-4803	164	10	transmembrane	transmembrane	ADJ
bam-4803	164	11	domain	domain	NOUN
bam-4803	164	12	,	,	PUNCT
bam-4803	164	13	and	and	CCONJ
bam-4803	164	14	yet	yet	ADV
bam-4803	164	15	they	they	PRON
bam-4803	164	16	bind	bind	VERB
bam-4803	164	17	almost	almost	ADV
bam-4803	164	18	irreversibly	irreversibly	ADV
bam-4803	164	19	in	in	ADP
bam-4803	164	20	the	the	DET
bam-4803	164	21	absence	absence	NOUN
bam-4803	164	22	of	of	ADP
bam-4803	164	23	detergent	detergent	NOUN
bam-4803	164	24	(	(	PUNCT
bam-4803	164	25	≥	≥	NOUN
bam-4803	164	26	cmc	cmc	PROPN
bam-4803	164	27	)	)	PUNCT
bam-4803	164	28	and	and	CCONJ
bam-4803	164	29	have	have	VERB
bam-4803	164	30	an	an	DET
bam-4803	164	31	exceedingly	exceedingly	ADV
bam-4803	164	32	low	low	ADJ
bam-4803	164	33	rate	rate	NOUN
bam-4803	164	34	of	of	ADP
bam-4803	164	35	spontaneous	spontaneous	ADJ
bam-4803	164	36	desorption	desorption	NOUN
bam-4803	164	37	.	.	PUNCT
bam-4803	165	1	72	72	NUM
bam-4803	166	1	however	however	ADV
bam-4803	166	2	,	,	PUNCT
bam-4803	166	3	apols	apol	NOUN
bam-4803	166	4	are	be	AUX
bam-4803	166	5	weak	weak	ADJ
bam-4803	166	6	membrane	membrane	NOUN
bam-4803	166	7	solubilizing	solubilize	VERB
bam-4803	166	8	surfactants	surfactant	NOUN
bam-4803	166	9	and	and	CCONJ
bam-4803	166	10	detergents	detergent	NOUN
bam-4803	166	11	are	be	AUX
bam-4803	166	12	still	still	ADV
bam-4803	166	13	necessary	necessary	ADJ
bam-4803	166	14	to	to	PART
bam-4803	166	15	extract	extract	VERB
bam-4803	166	16	membrane	membrane	NOUN
bam-4803	166	17	proteins	protein	NOUN
bam-4803	166	18	from	from	ADP
bam-4803	166	19	the	the	DET
bam-4803	166	20	lipid	lipid	NOUN
bam-4803	166	21	membrane	membrane	NOUN
bam-4803	166	22	.	.	PUNCT
bam-4803	167	1	detergents	detergent	NOUN
bam-4803	167	2	can	can	AUX
bam-4803	167	3	easily	easily	ADV
bam-4803	167	4	be	be	AUX
bam-4803	167	5	exchanged	exchange	VERB
bam-4803	167	6	for	for	ADP
bam-4803	167	7	apols	apol	NOUN
bam-4803	167	8	and	and	CCONJ
bam-4803	167	9	removed	remove	VERB
bam-4803	167	10	from	from	ADP
bam-4803	167	11	solution	solution	NOUN
bam-4803	167	12	allowing	allow	VERB
bam-4803	167	13	for	for	SCONJ
bam-4803	167	14	the	the	DET
bam-4803	167	15	membrane	membrane	NOUN
bam-4803	167	16	protein	protein	NOUN
bam-4803	167	17	to	to	PART
bam-4803	167	18	be	be	AUX
bam-4803	167	19	in	in	ADP
bam-4803	167	20	a	a	DET
bam-4803	167	21	milder	mild	ADJ
bam-4803	167	22	detergent	detergent	NOUN
bam-4803	167	23	-	-	PUNCT
bam-4803	167	24	free	free	ADJ
bam-4803	167	25	aqueous	aqueous	ADJ
bam-4803	167	26	environment	environment	NOUN
bam-4803	167	27	while	while	SCONJ
bam-4803	167	28	preventing	prevent	VERB
bam-4803	167	29	protein	protein	NOUN
bam-4803	167	30	aggregation	aggregation	NOUN
bam-4803	167	31	and	and	CCONJ
bam-4803	167	32	preserving	preserve	VERB
bam-4803	167	33	protein	protein	NOUN
bam-4803	167	34	structure	structure	NOUN
bam-4803	167	35	-	-	PUNCT
bam-4803	167	36	function	function	NOUN
bam-4803	167	37	stability.69	stability.69	NOUN
bam-4803	167	38	-	-	PUNCT
bam-4803	167	39	71	71	NUM
bam-4803	167	40	membrane	membrane	NOUN
bam-4803	167	41	proteins	protein	NOUN
bam-4803	167	42	are	be	AUX
bam-4803	167	43	structurally	structurally	ADV
bam-4803	167	44	flexible	flexible	ADJ
bam-4803	167	45	by	by	ADP
bam-4803	167	46	the	the	DET
bam-4803	167	47	very	very	ADJ
bam-4803	167	48	nature	nature	NOUN
bam-4803	167	49	of	of	ADP
bam-4803	167	50	their	their	PRON
bam-4803	167	51	function	function	NOUN
bam-4803	167	52	,	,	PUNCT
bam-4803	167	53	which	which	PRON
bam-4803	167	54	can	can	AUX
bam-4803	167	55	often	often	ADV
bam-4803	167	56	be	be	AUX
bam-4803	167	57	a	a	DET
bam-4803	167	58	detriment	detriment	NOUN
bam-4803	167	59	to	to	ADP
bam-4803	167	60	producing	produce	VERB
bam-4803	167	61	a	a	DET
bam-4803	167	62	structurally	structurally	ADV
bam-4803	167	63	homogenous	homogenous	ADJ
bam-4803	167	64	sample	sample	NOUN
bam-4803	167	65	.	.	PUNCT
bam-4803	168	1	apols	apol	NOUN
bam-4803	168	2	have	have	AUX
bam-4803	168	3	been	be	AUX
bam-4803	168	4	shown	show	VERB
bam-4803	168	5	to	to	PART
bam-4803	168	6	stabilize	stabilize	VERB
bam-4803	168	7	transmembrane	transmembrane	ADJ
bam-4803	168	8	domains	domain	NOUN
bam-4803	168	9	and	and	CCONJ
bam-4803	168	10	require	require	VERB
bam-4803	168	11	virtually	virtually	ADV
bam-4803	168	12	no	no	DET
bam-4803	168	13	excess	excess	ADJ
bam-4803	168	14	solution	solution	NOUN
bam-4803	168	15	concentration	concentration	NOUN
bam-4803	168	16	once	once	SCONJ
bam-4803	168	17	they	they	PRON
bam-4803	168	18	have	have	AUX
bam-4803	168	19	been	be	AUX
bam-4803	168	20	substituted	substitute	VERB
bam-4803	168	21	for	for	ADP
bam-4803	168	22	detergent	detergent	NOUN
bam-4803	168	23	.	.	PUNCT
bam-4803	169	1	70,73	70,73	NOUN
bam-4803	169	2	-	-	SYM
bam-4803	169	3	75	75	NUM
bam-4803	169	4	based	base	VERB
bam-4803	169	5	on	on	ADP
bam-4803	169	6	these	these	DET
bam-4803	169	7	favorable	favorable	ADJ
bam-4803	169	8	properties	property	NOUN
bam-4803	169	9	,	,	PUNCT
bam-4803	169	10	apols	apol	NOUN
bam-4803	169	11	are	be	AUX
bam-4803	169	12	a	a	DET
bam-4803	169	13	promising	promising	ADJ
bam-4803	169	14	option	option	NOUN
bam-4803	169	15	in	in	ADP
bam-4803	169	16	the	the	DET
bam-4803	169	17	pursuit	pursuit	NOUN
bam-4803	169	18	of	of	ADP
bam-4803	169	19	membrane	membrane	NOUN
bam-4803	169	20	protein	protein	NOUN
bam-4803	169	21	structures	structure	NOUN
bam-4803	169	22	by	by	ADP
bam-4803	169	23	cryoem	cryoem	NOUN
bam-4803	169	24	.	.	PUNCT
bam-4803	170	1	amphipol	amphipol	NOUN
bam-4803	170	2	8	8	NUM
bam-4803	170	3	-	-	SYM
bam-4803	170	4	35	35	NUM
bam-4803	170	5	(	(	PUNCT
bam-4803	170	6	a8	a8	PROPN
bam-4803	170	7	-	-	PUNCT
bam-4803	170	8	35	35	NUM
bam-4803	170	9	)	)	PUNCT
bam-4803	170	10	,	,	PUNCT
bam-4803	170	11	one	one	NUM
bam-4803	170	12	of	of	ADP
bam-4803	170	13	the	the	DET
bam-4803	170	14	most	most	ADV
bam-4803	170	15	wellcharacterized	wellcharacterized	ADJ
bam-4803	170	16	apol	apol	NOUN
bam-4803	170	17	,	,	PUNCT
bam-4803	170	18	appears	appear	VERB
bam-4803	170	19	to	to	PART
bam-4803	170	20	be	be	AUX
bam-4803	170	21	particularly	particularly	ADV
bam-4803	170	22	amenable	amenable	ADJ
bam-4803	170	23	for	for	ADP
bam-4803	170	24	single	single	ADJ
bam-4803	170	25	-	-	PUNCT
bam-4803	170	26	particle	particle	NOUN
bam-4803	170	27	cryo	cryo	NOUN
bam-4803	170	28	-	-	PUNCT
bam-4803	170	29	em	em	PRON
bam-4803	170	30	studies	study	NOUN
bam-4803	170	31	of	of	ADP
bam-4803	170	32	ion	ion	NOUN
bam-4803	170	33	channels.70	channels.70	X
bam-4803	170	34	our	our	PRON
bam-4803	170	35	group	group	NOUN
bam-4803	170	36	initiated	initiate	VERB
bam-4803	170	37	studies	study	NOUN
bam-4803	170	38	of	of	ADP
bam-4803	170	39	ryr1	ryr1	NOUN
bam-4803	170	40	in	in	ADP
bam-4803	170	41	complex	complex	ADJ
bam-4803	170	42	with	with	ADP
bam-4803	170	43	a8	a8	PROPN
bam-4803	170	44	-	-	PUNCT
bam-4803	170	45	35	35	NUM
bam-4803	170	46	,	,	PUNCT
bam-4803	170	47	a	a	DET
bam-4803	170	48	highly	highly	ADV
bam-4803	170	49	water	water	NOUN
bam-4803	170	50	-	-	PUNCT
bam-4803	170	51	soluble	soluble	ADJ
bam-4803	170	52	derivative	derivative	NOUN
bam-4803	170	53	of	of	ADP
bam-4803	170	54	polyacrylic	polyacrylic	ADJ
bam-4803	170	55	acid	acid	NOUN
bam-4803	170	56	.	.	PUNCT
bam-4803	171	1	70,76,77	70,76,77	NUM
bam-4803	171	2	in	in	ADP
bam-4803	171	3	cryo	cryo	NOUN
bam-4803	171	4	-	-	PUNCT
bam-4803	171	5	em	em	PRON
bam-4803	171	6	studies	study	NOUN
bam-4803	171	7	,	,	PUNCT
bam-4803	171	8	trapping	trap	VERB
bam-4803	171	9	detergent	detergent	NOUN
bam-4803	171	10	-	-	PUNCT
bam-4803	171	11	solubilized	solubilize	VERB
bam-4803	171	12	ryr1	ryr1	NOUN
bam-4803	171	13	with	with	ADP
bam-4803	171	14	a8	a8	PROPN
bam-4803	171	15	-	-	PUNCT
bam-4803	171	16	35	35	NUM
bam-4803	171	17	allowed	allow	VERB
bam-4803	171	18	reproducibility	reproducibility	NOUN
bam-4803	171	19	to	to	PART
bam-4803	171	20	vitrify	vitrify	VERB
bam-4803	171	21	ryr1	ryr1	NOUN
bam-4803	171	22	channel	channel	NOUN
bam-4803	171	23	within	within	ADP
bam-4803	171	24	the	the	DET
bam-4803	171	25	holes	hole	NOUN
bam-4803	171	26	of	of	ADP
bam-4803	171	27	a	a	DET
bam-4803	171	28	holey	holey	ADJ
bam-4803	171	29	-	-	PUNCT
bam-4803	171	30	carbon	carbon	NOUN
bam-4803	171	31	grids	grid	NOUN
bam-4803	171	32	with	with	ADP
bam-4803	171	33	particles	particle	NOUN
bam-4803	171	34	well	well	ADV
bam-4803	171	35	dispersed	disperse	VERB
bam-4803	171	36	throughout	throughout	ADP
bam-4803	171	37	the	the	DET
bam-4803	171	38	ice	ice	NOUN
bam-4803	171	39	(	(	PUNCT
bam-4803	171	40	fig	fig	NOUN
bam-4803	171	41	.	.	PUNCT
bam-4803	172	1	3a	3a	NUM
bam-4803	172	2	,	,	PUNCT
bam-4803	172	3	b	b	NOUN
bam-4803	172	4	)	)	PUNCT
bam-4803	172	5	.	.	PUNCT
bam-4803	173	1	our	our	PRON
bam-4803	173	2	initial	initial	ADJ
bam-4803	173	3	studies	study	NOUN
bam-4803	173	4	of	of	ADP
bam-4803	173	5	the	the	DET
bam-4803	173	6	vitrified	vitrified	ADJ
bam-4803	173	7	ryr1	ryr1	NOUN
bam-4803	173	8	/	/	SYM
bam-4803	173	9	a8	a8	PROPN
bam-4803	173	10	-	-	PUNCT
bam-4803	173	11	35	35	NUM
bam-4803	173	12	complex	complex	NOUN
bam-4803	173	13	showed	show	VERB
bam-4803	173	14	a	a	DET
bam-4803	173	15	strongly	strongly	ADV
bam-4803	173	16	preferred	prefer	VERB
bam-4803	173	17	particle	particle	NOUN
bam-4803	173	18	orientation	orientation	NOUN
bam-4803	173	19	,	,	PUNCT
bam-4803	173	20	similar	similar	ADJ
bam-4803	173	21	to	to	ADP
bam-4803	173	22	ryr1	ryr1	NOUN
bam-4803	173	23	protein	protein	NOUN
bam-4803	173	24	frozen	freeze	VERB
bam-4803	173	25	on	on	ADP
bam-4803	173	26	supporting	support	VERB
bam-4803	173	27	continuous	continuous	ADJ
bam-4803	173	28	carbon	carbon	NOUN
bam-4803	173	29	-	-	PUNCT
bam-4803	173	30	film	film	NOUN
bam-4803	173	31	.	.	PUNCT
bam-4803	174	1	the	the	DET
bam-4803	174	2	mechanism	mechanism	NOUN
bam-4803	174	3	behind	behind	ADP
bam-4803	174	4	why	why	SCONJ
bam-4803	174	5	ryr1	ryr1	NOUN
bam-4803	174	6	adopts	adopt	VERB
bam-4803	174	7	a	a	DET
bam-4803	174	8	preferred	preferred	ADJ
bam-4803	174	9	orientation	orientation	NOUN
bam-4803	174	10	in	in	ADP
bam-4803	174	11	comparison	comparison	NOUN
bam-4803	174	12	to	to	ADP
bam-4803	174	13	other	other	ADJ
bam-4803	174	14	membrane	membrane	NOUN
bam-4803	174	15	proteins	protein	NOUN
bam-4803	174	16	,	,	PUNCT
bam-4803	174	17	like	like	ADP
bam-4803	174	18	the	the	DET
bam-4803	174	19	ip3r	ip3r	PROPN
bam-4803	174	20	channel	channel	NOUN
bam-4803	174	21	,	,	PUNCT
bam-4803	174	22	is	be	AUX
bam-4803	174	23	unknown	unknown	ADJ
bam-4803	174	24	,	,	PUNCT
bam-4803	174	25	however	however	ADV
bam-4803	174	26	,	,	PUNCT
bam-4803	174	27	ryr1	ryr1	NOUN
bam-4803	174	28	’s	’s	PART
bam-4803	174	29	complexity	complexity	NOUN
bam-4803	174	30	of	of	ADP
bam-4803	174	31	surface	surface	NOUN
bam-4803	174	32	charges	charge	NOUN
bam-4803	174	33	combined	combine	VERB
bam-4803	174	34	with	with	ADP
bam-4803	174	35	its	its	PRON
bam-4803	174	36	awkward	awkward	ADJ
bam-4803	174	37	organization	organization	NOUN
bam-4803	174	38	in	in	ADP
bam-4803	174	39	3d	3d	PROPN
bam-4803	174	40	space	space	NOUN
bam-4803	174	41	due	due	ADP
bam-4803	174	42	to	to	ADP
bam-4803	174	43	its	its	PRON
bam-4803	174	44	enormous	enormous	ADJ
bam-4803	174	45	cytoplasmic	cytoplasmic	ADJ
bam-4803	174	46	domain	domain	NOUN
bam-4803	174	47	(	(	PUNCT
bam-4803	174	48	>	>	SYM
bam-4803	174	49	80	80	NUM
bam-4803	174	50	%	%	NOUN
bam-4803	174	51	of	of	ADP
bam-4803	174	52	protein	protein	NOUN
bam-4803	174	53	mass	mass	NOUN
bam-4803	174	54	)	)	PUNCT
bam-4803	174	55	likely	likely	ADV
bam-4803	174	56	play	play	VERB
bam-4803	174	57	a	a	DET
bam-4803	174	58	role	role	NOUN
bam-4803	174	59	in	in	ADP
bam-4803	174	60	driving	drive	VERB
bam-4803	174	61	the	the	DET
bam-4803	174	62	preferred	preferred	ADJ
bam-4803	174	63	orientation	orientation	NOUN
bam-4803	174	64	.	.	PUNCT
bam-4803	175	1	furthermore	furthermore	ADV
bam-4803	175	2	,	,	PUNCT
bam-4803	175	3	in	in	ADP
bam-4803	175	4	the	the	DET
bam-4803	175	5	presence	presence	NOUN
bam-4803	175	6	of	of	ADP
bam-4803	175	7	a8	a8	PROPN
bam-4803	175	8	-	-	PUNCT
bam-4803	175	9	35	35	NUM
bam-4803	175	10	,	,	PUNCT
bam-4803	175	11	we	we	PRON
bam-4803	175	12	believe	believe	VERB
bam-4803	175	13	that	that	SCONJ
bam-4803	175	14	the	the	DET
bam-4803	175	15	polymer	polymer	NOUN
bam-4803	175	16	forms	form	VERB
bam-4803	175	17	a	a	DET
bam-4803	175	18	negatively	negatively	ADV
bam-4803	175	19	charged	charge	VERB
bam-4803	175	20	film	film	NOUN
bam-4803	175	21	at	at	ADP
bam-4803	175	22	the	the	DET
bam-4803	175	23	water	water	NOUN
bam-4803	175	24	-	-	PUNCT
bam-4803	175	25	air	air	NOUN
bam-4803	175	26	interface	interface	NOUN
bam-4803	175	27	during	during	ADP
bam-4803	175	28	sample	sample	NOUN
bam-4803	175	29	application	application	NOUN
bam-4803	175	30	to	to	ADP
bam-4803	175	31	the	the	DET
bam-4803	175	32	em	em	PROPN
bam-4803	175	33	grid	grid	NOUN
bam-4803	175	34	resulting	result	VERB
bam-4803	175	35	in	in	ADP
bam-4803	175	36	channel	channel	NOUN
bam-4803	175	37	particles	particle	NOUN
bam-4803	175	38	in	in	ADP
bam-4803	175	39	a	a	DET
bam-4803	175	40	preferred	preferred	ADJ
bam-4803	175	41	orientation	orientation	NOUN
bam-4803	175	42	.	.	PUNCT
bam-4803	176	1	the	the	DET
bam-4803	176	2	addition	addition	NOUN
bam-4803	176	3	of	of	ADP
bam-4803	176	4	octyl	octyl	NOUN
bam-4803	176	5	-	-	PUNCT
bam-4803	176	6	glucoside	glucoside	NOUN
bam-4803	176	7	(	(	PUNCT
bam-4803	176	8	og	og	PROPN
bam-4803	176	9	)	)	PUNCT
bam-4803	176	10	in	in	ADP
bam-4803	176	11	a	a	DET
bam-4803	176	12	table	table	NOUN
bam-4803	176	13	1	1	NUM
bam-4803	176	14	.	.	PUNCT
bam-4803	176	15	detergent	detergent	NOUN
bam-4803	176	16	properties	property	NOUN
bam-4803	176	17	used	use	VERB
bam-4803	176	18	in	in	ADP
bam-4803	176	19	single	single	ADJ
bam-4803	176	20	-	-	PUNCT
bam-4803	176	21	particle	particle	NOUN
bam-4803	176	22	cryo	cryo	NOUN
bam-4803	176	23	-	-	PUNCT
bam-4803	176	24	em	em	PRON
bam-4803	176	25	of	of	ADP
bam-4803	176	26	ion	ion	NOUN
bam-4803	176	27	channels	channel	NOUN
bam-4803	176	28	.	.	PUNCT
bam-4803	177	1	the	the	DET
bam-4803	177	2	physical	physical	ADJ
bam-4803	177	3	properties	property	NOUN
bam-4803	177	4	of	of	ADP
bam-4803	177	5	used	use	VERB
bam-4803	177	6	detergents	detergent	NOUN
bam-4803	177	7	including	include	VERB
bam-4803	177	8	cmc	cmc	NOUN
bam-4803	177	9	,	,	PUNCT
bam-4803	177	10	micelle	micelle	NOUN
bam-4803	177	11	size	size	NOUN
bam-4803	177	12	and	and	CCONJ
bam-4803	177	13	molecular	molecular	ADJ
bam-4803	177	14	weight	weight	NOUN
bam-4803	177	15	are	be	AUX
bam-4803	177	16	important	important	ADJ
bam-4803	177	17	considerations	consideration	NOUN
bam-4803	177	18	when	when	SCONJ
bam-4803	177	19	optimizing	optimize	VERB
bam-4803	177	20	cryospecimen	cryospeciman	NOUN
bam-4803	177	21	conditions	condition	NOUN
bam-4803	177	22	.	.	PUNCT
bam-4803	178	1	detergent	detergent	NOUN
bam-4803	178	2	cmc	cmc	NOUN
bam-4803	178	3	(	(	PUNCT
bam-4803	178	4	mm	mm	NOUN
bam-4803	178	5	)	)	PUNCT
bam-4803	178	6	cmc	cmc	NOUN
bam-4803	178	7	(	(	PUNCT
bam-4803	178	8	%	%	INTJ
bam-4803	178	9	w	w	PROPN
bam-4803	178	10	/	/	SYM
bam-4803	178	11	v	v	NOUN
bam-4803	178	12	)	)	PUNCT
bam-4803	178	13	micelle	micelle	NOUN
bam-4803	178	14	size	size	NOUN
bam-4803	178	15	(	(	PUNCT
bam-4803	178	16	da	da	NOUN
bam-4803	178	17	)	)	PUNCT
bam-4803	178	18	molecular	molecular	ADJ
bam-4803	178	19	weight	weight	NOUN
bam-4803	178	20	aggregation	aggregation	NOUN
bam-4803	178	21	number	number	NOUN
bam-4803	178	22	chaps	chap	VERB
bam-4803	178	23	3-[(3	3-[(3	NUM
bam-4803	178	24	-	-	PUNCT
bam-4803	178	25	cholamidopropyl)dimethyl	cholamidopropyl)dimethyl	NOUN
bam-4803	178	26	-	-	PUNCT
bam-4803	178	27	ammonio]-1propanesulfonate	ammonio]-1propanesulfonate	NOUN
bam-4803	178	28	8	8	NUM
bam-4803	178	29	0.5	0.5	NUM
bam-4803	178	30	6,150	6,150	NUM
bam-4803	178	31	615	615	NUM
bam-4803	178	32	10	10	NUM
bam-4803	178	33	triton	triton	PROPN
bam-4803	178	34	x-100	x-100	PROPN
bam-4803	178	35	polyethylene	polyethylene	NOUN
bam-4803	178	36	glycol	glycol	NOUN
bam-4803	178	37	p-(1,1,3,3tetramethylbutyl)-phenyl	p-(1,1,3,3tetramethylbutyl)-phenyl	PROPN
bam-4803	178	38	ether	ether	NOUN
bam-4803	178	39	0.22	0.22	NUM
bam-4803	178	40	0.24	0.24	NUM
bam-4803	178	41	0.01	0.01	NUM
bam-4803	178	42	-	-	PUNCT
bam-4803	178	43	0.016	0.016	NUM
bam-4803	178	44	90,000	90,000	NUM
bam-4803	178	45	625	625	NUM
bam-4803	178	46	100	100	NUM
bam-4803	178	47	-	-	SYM
bam-4803	178	48	155	155	NUM
bam-4803	178	49	digitonin	digitonin	NOUN
bam-4803	178	50	<	<	X
bam-4803	178	51	0.5	0.5	NUM
bam-4803	178	52	0.02	0.02	NUM
bam-4803	178	53	70,000	70,000	NUM
bam-4803	178	54	1,229	1,229	NUM
bam-4803	178	55	60	60	NUM
bam-4803	178	56	ddm	ddm	PROPN
bam-4803	178	57	n	n	CCONJ
bam-4803	178	58	-	-	PUNCT
bam-4803	178	59	dodecylβ	dodecylβ	NOUN
bam-4803	178	60	-	-	PUNCT
bam-4803	178	61	d	d	NOUN
bam-4803	178	62	-	-	NOUN
bam-4803	178	63	maltoside	maltoside	NOUN
bam-4803	178	64	0.17	0.17	NUM
bam-4803	178	65	0.0087	0.0087	NUM
bam-4803	178	66	72,000	72,000	NUM
bam-4803	178	67	511	511	NUM
bam-4803	178	68	78	78	NUM
bam-4803	178	69	-	-	SYM
bam-4803	178	70	149	149	NUM
bam-4803	178	71	dm	dm	PROPN
bam-4803	178	72	n	n	CCONJ
bam-4803	178	73	-	-	PUNCT
bam-4803	178	74	decyl	decyl	NOUN
bam-4803	178	75	-	-	PUNCT
bam-4803	178	76	β	β	NOUN
bam-4803	178	77	-	-	PUNCT
bam-4803	178	78	d	d	NOUN
bam-4803	178	79	-	-	NOUN
bam-4803	178	80	maltopyranosid	maltopyranosid	ADJ
bam-4803	178	81	1.8	1.8	NUM
bam-4803	178	82	0.087	0.087	NUM
bam-4803	178	83	33,000	33,000	NUM
bam-4803	178	84	483	483	NUM
bam-4803	178	85	98	98	NUM
bam-4803	178	86	og	og	PROPN
bam-4803	178	87	n	n	CCONJ
bam-4803	178	88	-	-	PUNCT
bam-4803	178	89	octyl	octyl	NOUN
bam-4803	178	90	-	-	PUNCT
bam-4803	178	91	β	β	NOUN
bam-4803	178	92	-	-	ADJ
bam-4803	178	93	d	d	NOUN
bam-4803	178	94	-	-	NOUN
bam-4803	178	95	glucoside	glucoside	NOUN
bam-4803	178	96	23	23	NUM
bam-4803	178	97	-	-	SYM
bam-4803	178	98	25	25	NUM
bam-4803	178	99	0.67	0.67	NUM
bam-4803	178	100	-	-	PUNCT
bam-4803	178	101	0.73	0.73	NUM
bam-4803	178	102	8,000	8,000	NUM
bam-4803	178	103	292	292	NUM
bam-4803	178	104	27	27	NUM
bam-4803	178	105	-	-	SYM
bam-4803	178	106	100	100	NUM
bam-4803	178	107	single	single	ADJ
bam-4803	178	108	-	-	PUNCT
bam-4803	178	109	particle	particle	NOUN
bam-4803	178	110	cryo	cryo	NOUN
bam-4803	178	111	-	-	PUNCT
bam-4803	178	112	em	em	PRON
bam-4803	178	113	of	of	ADP
bam-4803	178	114	the	the	DET
bam-4803	178	115	ryanodine	ryanodine	PROPN
bam-4803	178	116	receptor	receptor	NOUN
bam-4803	178	117	channel	channel	PROPN
bam-4803	178	118	eur	eur	PROPN
bam-4803	178	119	j	j	PROPN
bam-4803	178	120	transl	transl	PROPN
bam-4803	178	121	myol	myol	PROPN
bam-4803	178	122	basic	basic	ADJ
bam-4803	178	123	appl	appl	NOUN
bam-4803	178	124	myol	myol	NOUN
bam-4803	178	125	2015	2015	NUM
bam-4803	178	126	;	;	PUNCT
bam-4803	178	127	25	25	NUM
bam-4803	178	128	(	(	PUNCT
bam-4803	178	129	1	1	NUM
bam-4803	178	130	):	):	PUNCT
bam-4803	178	131	35	35	NUM
bam-4803	178	132	-	-	SYM
bam-4803	178	133	48	48	NUM
bam-4803	178	134	43	43	NUM
bam-4803	178	135	concentration	concentration	NOUN
bam-4803	178	136	10	10	NUM
bam-4803	178	137	times	time	NOUN
bam-4803	178	138	below	below	ADP
bam-4803	178	139	its	its	PRON
bam-4803	178	140	cmc	cmc	NOUN
bam-4803	178	141	resulted	result	VERB
bam-4803	178	142	in	in	ADP
bam-4803	178	143	a	a	DET
bam-4803	178	144	random	random	ADJ
bam-4803	178	145	distribution	distribution	NOUN
bam-4803	178	146	of	of	ADP
bam-4803	178	147	channel	channel	NOUN
bam-4803	178	148	particles	particle	NOUN
bam-4803	178	149	that	that	PRON
bam-4803	178	150	we	we	PRON
bam-4803	178	151	believe	believe	VERB
bam-4803	178	152	is	be	AUX
bam-4803	178	153	caused	cause	VERB
bam-4803	178	154	by	by	ADP
bam-4803	178	155	og	og	NOUN
bam-4803	178	156	disrupting	disrupt	VERB
bam-4803	178	157	the	the	DET
bam-4803	178	158	polymer	polymer	NOUN
bam-4803	178	159	film	film	NOUN
bam-4803	178	160	(	(	PUNCT
bam-4803	178	161	fig	fig	NOUN
bam-4803	178	162	.	.	PUNCT
bam-4803	179	1	3c	3c	NUM
bam-4803	179	2	)	)	PUNCT
bam-4803	179	3	.	.	PUNCT
bam-4803	180	1	detergents	detergent	NOUN
bam-4803	180	2	below	below	ADP
bam-4803	180	3	their	their	PRON
bam-4803	180	4	cmc	cmc	NOUN
bam-4803	180	5	remain	remain	VERB
bam-4803	180	6	as	as	ADP
bam-4803	180	7	monomers	monomer	NOUN
bam-4803	180	8	in	in	ADP
bam-4803	180	9	solution	solution	NOUN
bam-4803	180	10	and	and	CCONJ
bam-4803	180	11	do	do	AUX
bam-4803	180	12	not	not	PART
bam-4803	180	13	disrupt	disrupt	VERB
bam-4803	180	14	the	the	DET
bam-4803	180	15	apol	apol	NOUN
bam-4803	180	16	/	/	SYM
bam-4803	180	17	membrane	membrane	NOUN
bam-4803	180	18	protein	protein	NOUN
bam-4803	180	19	complex	complex	NOUN
bam-4803	180	20	and	and	CCONJ
bam-4803	180	21	no	no	DET
bam-4803	180	22	significant	significant	ADJ
bam-4803	180	23	table	table	NOUN
bam-4803	180	24	2	2	NUM
bam-4803	180	25	.	.	PUNCT
bam-4803	181	1	attributes	attribute	NOUN
bam-4803	181	2	of	of	ADP
bam-4803	181	3	membrane	membrane	NOUN
bam-4803	181	4	protein	protein	NOUN
bam-4803	181	5	complexes	complex	NOUN
bam-4803	181	6	determined	determine	VERB
bam-4803	181	7	by	by	ADP
bam-4803	181	8	single	single	ADJ
bam-4803	181	9	-	-	PUNCT
bam-4803	181	10	particle	particle	NOUN
bam-4803	181	11	cryo	cryo	NOUN
bam-4803	181	12	-	-	PUNCT
bam-4803	181	13	em	em	PROPN
bam-4803	181	14	.	.	PUNCT
bam-4803	182	1	a	a	DET
bam-4803	182	2	summary	summary	NOUN
bam-4803	182	3	of	of	ADP
bam-4803	182	4	membrane	membrane	NOUN
bam-4803	182	5	protein	protein	NOUN
bam-4803	182	6	structural	structural	ADJ
bam-4803	182	7	studies	study	NOUN
bam-4803	182	8	and	and	CCONJ
bam-4803	182	9	cryospecimen	cryospeciman	NOUN
bam-4803	182	10	surfactants	surfactant	NOUN
bam-4803	182	11	used	use	VERB
bam-4803	182	12	.	.	PUNCT
bam-4803	183	1	listed	list	VERB
bam-4803	183	2	for	for	ADP
bam-4803	183	3	each	each	DET
bam-4803	183	4	macromolecular	macromolecular	ADJ
bam-4803	183	5	complex	complex	NOUN
bam-4803	183	6	is	be	AUX
bam-4803	183	7	the	the	DET
bam-4803	183	8	:	:	PUNCT
bam-4803	183	9	molecular	molecular	ADJ
bam-4803	183	10	weight	weight	NOUN
bam-4803	183	11	,	,	PUNCT
bam-4803	183	12	emdatabank	emdatabank	VERB
bam-4803	183	13	[	[	X
bam-4803	183	14	emd	emd	X
bam-4803	183	15	]	]	PUNCT
bam-4803	183	16	identification	identification	NOUN
bam-4803	183	17	number	number	NOUN
bam-4803	183	18	,	,	PUNCT
bam-4803	183	19	when	when	SCONJ
bam-4803	183	20	available	available	ADJ
bam-4803	183	21	,	,	PUNCT
bam-4803	183	22	author	author	NOUN
bam-4803	183	23	’s	’s	PART
bam-4803	183	24	reported	report	VERB
bam-4803	183	25	resolution	resolution	NOUN
bam-4803	183	26	(	(	PUNCT
bam-4803	183	27	å	å	NOUN
bam-4803	183	28	)	)	PUNCT
bam-4803	183	29	and	and	CCONJ
bam-4803	183	30	surfactant	surfactant	ADJ
bam-4803	183	31	type	type	NOUN
bam-4803	183	32	and	and	CCONJ
bam-4803	183	33	amount	amount	NOUN
bam-4803	183	34	present	present	ADJ
bam-4803	183	35	in	in	ADP
bam-4803	183	36	cryospecimen	cryospeciman	NOUN
bam-4803	183	37	.	.	PUNCT
bam-4803	184	1	membrane	membrane	NOUN
bam-4803	184	2	protein	protein	NOUN
bam-4803	184	3	m.w	m.w	PROPN
bam-4803	184	4	.	.	PUNCT
bam-4803	185	1	(	(	PUNCT
bam-4803	185	2	mda	mda	PROPN
bam-4803	185	3	)	)	PUNCT
bam-4803	185	4	emdb	emdb	PROPN
bam-4803	186	1	i	i	PROPN
bam-4803	186	2	d	d	PROPN
bam-4803	186	3	resolution	resolution	NOUN
bam-4803	186	4	(	(	PUNCT
bam-4803	186	5	å	å	NOUN
bam-4803	186	6	)	)	PUNCT
bam-4803	186	7	surfactant	surfactant	NOUN
bam-4803	186	8	and	and	CCONJ
bam-4803	186	9	amount	amount	NOUN
bam-4803	186	10	reported	report	VERB
bam-4803	186	11	in	in	ADP
bam-4803	186	12	cryospecimen	cryospeciman	NOUN
bam-4803	186	13	refs	ref	NOUN
bam-4803	186	14	.	.	PUNCT
bam-4803	187	1	surfactant	surfactant	PROPN
bam-4803	187	2	amt	amt	PROPN
bam-4803	187	3	x	x	PUNCT
bam-4803	187	4	cmc	cmc	NOUN
bam-4803	187	5	intracellular	intracellular	NOUN
bam-4803	187	6	ca	can	AUX
bam-4803	187	7	2	2	NUM
bam-4803	187	8	+	+	NOUN
bam-4803	187	9	release	release	NOUN
bam-4803	187	10	channels	channel	NOUN
bam-4803	187	11	ryr1	ryr1	VERB
bam-4803	187	12	2.3	2.3	NUM
bam-4803	187	13	1274	1274	NUM
bam-4803	187	14	14	14	NUM
bam-4803	187	15	chaps	chap	NOUN
bam-4803	187	16	0.40	0.40	NUM
bam-4803	187	17	%	%	NOUN
bam-4803	187	18	0.8	0.8	NUM
bam-4803	187	19	-	-	SYM
bam-4803	187	20	1	1	NUM
bam-4803	187	21	(	(	PUNCT
bam-4803	187	22	38	38	NUM
bam-4803	187	23	)	)	PUNCT
bam-4803	187	24	1275	1275	NUM
bam-4803	187	25	9.6	9.6	NUM
bam-4803	187	26	chaps	chap	NOUN
bam-4803	187	27	0.40	0.40	NUM
bam-4803	187	28	%	%	NOUN
bam-4803	187	29	0.8	0.8	NUM
bam-4803	187	30	-	-	SYM
bam-4803	187	31	1	1	NUM
bam-4803	187	32	(	(	PUNCT
bam-4803	187	33	37	37	NUM
bam-4803	187	34	)	)	PUNCT
bam-4803	187	35	5014	5014	NUM
bam-4803	187	36	10.3	10.3	NUM
bam-4803	187	37	chaps	chap	NOUN
bam-4803	187	38	0.50	0.50	NUM
bam-4803	187	39	%	%	NOUN
bam-4803	187	40	1	1	NUM
bam-4803	187	41	(	(	PUNCT
bam-4803	187	42	40	40	NUM
bam-4803	187	43	)	)	PUNCT
bam-4803	187	44	1607	1607	NUM
bam-4803	187	45	,	,	PUNCT
bam-4803	187	46	1606	1606	NUM
bam-4803	187	47	10.2	10.2	NUM
bam-4803	187	48	chaps	chap	NOUN
bam-4803	187	49	0.50	0.50	NUM
bam-4803	187	50	%	%	NOUN
bam-4803	187	51	1	1	NUM
bam-4803	187	52	(	(	PUNCT
bam-4803	187	53	41	41	NUM
bam-4803	187	54	)	)	PUNCT
bam-4803	187	55	ip3r1	ip3r1	PROPN
bam-4803	187	56	1.3	1.3	NUM
bam-4803	187	57	—	—	SYM
bam-4803	187	58	24	24	NUM
bam-4803	187	59	chaps	chap	NOUN
bam-4803	187	60	0.40	0.40	NUM
bam-4803	187	61	%	%	NOUN
bam-4803	187	62	0.8	0.8	NUM
bam-4803	187	63	-	-	SYM
bam-4803	187	64	1	1	NUM
bam-4803	187	65	(	(	PUNCT
bam-4803	187	66	83	83	NUM
bam-4803	187	67	)	)	PUNCT
bam-4803	187	68	—	—	PUNCT
bam-4803	187	69	30	30	NUM
bam-4803	187	70	triton	triton	PROPN
bam-4803	187	71	x-100	x-100	PROPN
bam-4803	187	72	0.15	0.15	NUM
bam-4803	187	73	%	%	NOUN
bam-4803	187	74	>	>	X
bam-4803	187	75	10	10	NUM
bam-4803	187	76	(	(	PUNCT
bam-4803	187	77	84	84	NUM
bam-4803	187	78	)	)	PUNCT
bam-4803	187	79	5278	5278	NUM
bam-4803	187	80	10	10	NUM
bam-4803	187	81	chaps	chap	NOUN
bam-4803	187	82	0.40	0.40	NUM
bam-4803	187	83	%	%	NOUN
bam-4803	187	84	0.8	0.8	NUM
bam-4803	187	85	-	-	SYM
bam-4803	187	86	1	1	NUM
bam-4803	187	87	(	(	PUNCT
bam-4803	187	88	85	85	NUM
bam-4803	187	89	)	)	PUNCT
bam-4803	187	90	1061	1061	NUM
bam-4803	187	91	20	20	NUM
bam-4803	187	92	chaps	chap	NOUN
bam-4803	187	93	1	1	NUM
bam-4803	187	94	%	%	NOUN
bam-4803	187	95	2	2	NUM
bam-4803	187	96	(	(	PUNCT
bam-4803	187	97	86	86	NUM
bam-4803	187	98	)	)	PUNCT
bam-4803	187	99	voltage	voltage	NOUN
bam-4803	187	100	gated	gate	VERB
bam-4803	187	101	ca	ca	NOUN
bam-4803	187	102	2	2	NUM
bam-4803	187	103	+	+	NOUN
bam-4803	187	104	channel	channel	NOUN
bam-4803	187	105	dhpr	dhpr	NOUN
bam-4803	187	106	(	(	PUNCT
bam-4803	187	107	cav1.1	cav1.1	NOUN
bam-4803	187	108	)	)	PUNCT
bam-4803	187	109	0.55	0.55	NUM
bam-4803	187	110	—	—	PUNCT
bam-4803	187	111	25	25	NUM
bam-4803	187	112	digitonin	digitonin	NOUN
bam-4803	187	113	0.10	0.10	NUM
bam-4803	187	114	%	%	NOUN
bam-4803	187	115	5	5	NUM
bam-4803	187	116	(	(	PUNCT
bam-4803	187	117	87	87	NUM
bam-4803	187	118	)	)	PUNCT
bam-4803	187	119	1069	1069	NUM
bam-4803	187	120	25	25	NUM
bam-4803	187	121	digitonin	digitonin	NOUN
bam-4803	187	122	0.10	0.10	NUM
bam-4803	187	123	%	%	NOUN
bam-4803	187	124	5	5	NUM
bam-4803	187	125	(	(	PUNCT
bam-4803	187	126	88	88	NUM
bam-4803	187	127	)	)	PUNCT
bam-4803	187	128	transient	transient	ADJ
bam-4803	187	129	receptor	receptor	NOUN
bam-4803	187	130	potential	potential	NOUN
bam-4803	187	131	(	(	PUNCT
bam-4803	187	132	trp	trp	NOUN
bam-4803	187	133	)	)	PUNCT
bam-4803	187	134	channels	channel	NOUN
bam-4803	187	135	trpc3	trpc3	VERB
bam-4803	187	136	0.388	0.388	NUM
bam-4803	187	137	—	—	SYM
bam-4803	187	138	15	15	NUM
bam-4803	187	139	dm	dm	NUM
bam-4803	187	140	5	5	NUM
bam-4803	187	141	mm	mm	NOUN
bam-4803	187	142	2.7	2.7	NUM
bam-4803	187	143	(	(	PUNCT
bam-4803	187	144	89	89	NUM
bam-4803	187	145	)	)	PUNCT
bam-4803	187	146	trpv4	trpv4	NOUN
bam-4803	188	1	0.39	0.39	NUM
bam-4803	188	2	—	—	PUNCT
bam-4803	188	3	35	35	NUM
bam-4803	188	4	ddm	ddm	NOUN
bam-4803	188	5	1	1	NUM
bam-4803	188	6	mm	mm	PROPN
bam-4803	188	7	5.9	5.9	NUM
bam-4803	188	8	(	(	PUNCT
bam-4803	188	9	90	90	NUM
bam-4803	188	10	)	)	PUNCT
bam-4803	188	11	trpv1	trpv1	NOUN
bam-4803	188	12	0.3	0.3	NUM
bam-4803	188	13	—	—	PUNCT
bam-4803	188	14	19	19	NUM
bam-4803	188	15	dm	dm	NUM
bam-4803	188	16	0.1	0.1	NUM
bam-4803	188	17	%	%	NOUN
bam-4803	188	18	1.15	1.15	NUM
bam-4803	188	19	(	(	PUNCT
bam-4803	188	20	91	91	NUM
bam-4803	188	21	)	)	PUNCT
bam-4803	188	22	trpv1	trpv1	NOUN
bam-4803	189	1	0.3	0.3	NUM
bam-4803	189	2	5778	5778	NUM
bam-4803	189	3	3.27	3.27	NUM
bam-4803	189	4	apol	apol	NOUN
bam-4803	189	5	1:3	1:3	NUM
bam-4803	189	6	(	(	PUNCT
bam-4803	189	7	w	w	PROPN
bam-4803	189	8	/	/	SYM
bam-4803	189	9	w	w	NOUN
bam-4803	189	10	)	)	PUNCT
bam-4803	189	11	—	—	PUNCT
bam-4803	189	12	(	(	PUNCT
bam-4803	189	13	13	13	NUM
bam-4803	189	14	)	)	PUNCT
bam-4803	189	15	trpv1	trpv1	NOUN
bam-4803	189	16	0.3	0.3	NUM
bam-4803	189	17	5776	5776	NUM
bam-4803	189	18	,	,	PUNCT
bam-4803	189	19	5777	5777	NUM
bam-4803	189	20	3.8	3.8	NUM
bam-4803	189	21	4.2	4.2	NUM
bam-4803	189	22	apol	apol	NOUN
bam-4803	189	23	1:3	1:3	NUM
bam-4803	189	24	(	(	PUNCT
bam-4803	189	25	w	w	PROPN
bam-4803	189	26	/	/	SYM
bam-4803	189	27	w	w	NOUN
bam-4803	189	28	)	)	PUNCT
bam-4803	189	29	—	—	PUNCT
bam-4803	189	30	(	(	PUNCT
bam-4803	189	31	12	12	NUM
bam-4803	189	32	)	)	PUNCT
bam-4803	189	33	trpv2	trpv2	NOUN
bam-4803	189	34	0.36	0.36	NUM
bam-4803	189	35	5688	5688	NUM
bam-4803	189	36	13.6	13.6	NUM
bam-4803	189	37	decyl	decyl	NOUN
bam-4803	189	38	-	-	PUNCT
bam-4803	189	39	mng	mng	NOUN
bam-4803	189	40	0.006	0.006	NUM
bam-4803	189	41	%	%	NOUN
bam-4803	189	42	1.8	1.8	NUM
bam-4803	189	43	(	(	PUNCT
bam-4803	189	44	92	92	NUM
bam-4803	189	45	)	)	PUNCT
bam-4803	189	46	trpa1	trpa1	NOUN
bam-4803	189	47	0.525	0.525	NUM
bam-4803	189	48	5334	5334	NUM
bam-4803	189	49	16	16	NUM
bam-4803	189	50	a8	a8	PROPN
bam-4803	189	51	-	-	PUNCT
bam-4803	189	52	35	35	NUM
bam-4803	189	53	1:2.3	1:2.3	NUM
bam-4803	189	54	(	(	PUNCT
bam-4803	189	55	w	w	NOUN
bam-4803	189	56	/	/	SYM
bam-4803	189	57	w	w	NOUN
bam-4803	189	58	)	)	PUNCT
bam-4803	189	59	—	—	PUNCT
bam-4803	189	60	(	(	PUNCT
bam-4803	189	61	93	93	NUM
bam-4803	189	62	)	)	PUNCT
bam-4803	189	63	other	other	ADJ
bam-4803	189	64	membrane	membrane	NOUN
bam-4803	189	65	proteins	protein	NOUN
bam-4803	189	66	kvap	kvap	NOUN
bam-4803	189	67	-	-	PUNCT
bam-4803	189	68	fab	fab	NOUN
bam-4803	189	69	0.3	0.3	NUM
bam-4803	189	70	1094	1094	NUM
bam-4803	189	71	10.5	10.5	NUM
bam-4803	189	72	dm	dm	NUM
bam-4803	189	73	5	5	NUM
bam-4803	189	74	mm	mm	NUM
bam-4803	189	75	2.7	2.7	NUM
bam-4803	189	76	(	(	PUNCT
bam-4803	189	77	94	94	NUM
bam-4803	189	78	)	)	PUNCT
bam-4803	189	79	mca	mca	PROPN
bam-4803	189	80	channel	channel	NOUN
bam-4803	189	81	0.2	0.2	NUM
bam-4803	189	82	2313	2313	NUM
bam-4803	189	83	26	26	NUM
bam-4803	189	84	ammonium	ammonium	NOUN
bam-4803	189	85	perfluorooctanoate	perfluorooctanoate	NOUN
bam-4803	189	86	4	4	NUM
bam-4803	189	87	%	%	NOUN
bam-4803	189	88	3.4	3.4	NUM
bam-4803	189	89	(	(	PUNCT
bam-4803	189	90	95	95	NUM
bam-4803	190	1	)	)	PUNCT
bam-4803	190	2	glur	glur	NOUN
bam-4803	190	3	0.37	0.37	NUM
bam-4803	190	4	2680	2680	NUM
bam-4803	190	5	2684	2684	NUM
bam-4803	190	6	2685	2685	NUM
bam-4803	190	7	2686	2686	NUM
bam-4803	190	8	2687	2687	NUM
bam-4803	190	9	2688	2688	NUM
bam-4803	190	10	2689	2689	NUM
bam-4803	190	11	10.4	10.4	NUM
bam-4803	190	12	12.8	12.8	NUM
bam-4803	190	13	7.6	7.6	NUM
bam-4803	190	14	21.4	21.4	NUM
bam-4803	190	15	25.9	25.9	NUM
bam-4803	190	16	22.9	22.9	NUM
bam-4803	190	17	16.4	16.4	NUM
bam-4803	190	18	ddm	ddm	NOUN
bam-4803	190	19	0.75	0.75	NUM
bam-4803	190	20	mm	mm	PROPN
bam-4803	190	21	4.4	4.4	NUM
bam-4803	190	22	(	(	PUNCT
bam-4803	190	23	62	62	NUM
bam-4803	190	24	)	)	PUNCT
bam-4803	190	25	-secretase	-secretase	X
bam-4803	190	26	0.17	0.17	NUM
bam-4803	190	27	2677	2677	NUM
bam-4803	190	28	,	,	PUNCT
bam-4803	190	29	2678	2678	NUM
bam-4803	190	30	4.5	4.5	NUM
bam-4803	190	31	5.4	5.4	NUM
bam-4803	190	32	a8	a8	PROPN
bam-4803	190	33	-	-	PUNCT
bam-4803	190	34	35	35	NUM
bam-4803	190	35	1:3	1:3	NUM
bam-4803	190	36	(	(	PUNCT
bam-4803	190	37	w	w	PROPN
bam-4803	190	38	/	/	SYM
bam-4803	190	39	w	w	NOUN
bam-4803	190	40	)	)	PUNCT
bam-4803	190	41	—	—	PUNCT
bam-4803	190	42	(	(	PUNCT
bam-4803	190	43	14	14	X
bam-4803	190	44	)	)	PUNCT
bam-4803	190	45	atpase	atpase	PROPN
bam-4803	190	46	0.6	0.6	NUM
bam-4803	190	47	5335	5335	NUM
bam-4803	190	48	9.7	9.7	NUM
bam-4803	190	49	ddm	ddm	NOUN
bam-4803	190	50	0.02	0.02	NUM
bam-4803	190	51	%	%	NOUN
bam-4803	190	52	2.3	2.3	NUM
bam-4803	190	53	(	(	PUNCT
bam-4803	190	54	96	96	NUM
bam-4803	190	55	)	)	PUNCT
bam-4803	190	56	0.9	0.9	NUM
bam-4803	190	57	5476	5476	NUM
bam-4803	190	58	11	11	NUM
bam-4803	190	59	ddm	ddm	NOUN
bam-4803	190	60	0.03	0.03	NUM
bam-4803	190	61	%	%	NOUN
bam-4803	190	62	3.4	3.4	NUM
bam-4803	190	63	(	(	PUNCT
bam-4803	190	64	97	97	NUM
bam-4803	190	65	)	)	PUNCT
bam-4803	190	66	single	single	ADJ
bam-4803	190	67	-	-	PUNCT
bam-4803	190	68	particle	particle	NOUN
bam-4803	190	69	cryo	cryo	NOUN
bam-4803	190	70	-	-	PUNCT
bam-4803	190	71	em	em	PRON
bam-4803	190	72	of	of	ADP
bam-4803	190	73	the	the	DET
bam-4803	190	74	ryanodine	ryanodine	PROPN
bam-4803	190	75	receptor	receptor	NOUN
bam-4803	190	76	channel	channel	PROPN
bam-4803	190	77	eur	eur	PROPN
bam-4803	190	78	j	j	PROPN
bam-4803	190	79	transl	transl	PROPN
bam-4803	190	80	myol	myol	PROPN
bam-4803	190	81	basic	basic	ADJ
bam-4803	190	82	appl	appl	NOUN
bam-4803	190	83	myol	myol	NOUN
bam-4803	190	84	2015	2015	NUM
bam-4803	190	85	;	;	PUNCT
bam-4803	190	86	25	25	NUM
bam-4803	190	87	(	(	PUNCT
bam-4803	190	88	1	1	NUM
bam-4803	190	89	):	):	PUNCT
bam-4803	190	90	35	35	NUM
bam-4803	190	91	-	-	SYM
bam-4803	190	92	48	48	NUM
bam-4803	190	93	44	44	NUM
bam-4803	190	94	loss	loss	NOUN
bam-4803	190	95	of	of	ADP
bam-4803	190	96	signal	signal	NOUN
bam-4803	190	97	was	be	AUX
bam-4803	190	98	observed	observe	VERB
bam-4803	190	99	.	.	PUNCT
bam-4803	191	1	72	72	NUM
bam-4803	191	2	similar	similar	ADJ
bam-4803	191	3	approaches	approach	NOUN
bam-4803	191	4	for	for	ADP
bam-4803	191	5	adding	add	VERB
bam-4803	191	6	small	small	ADJ
bam-4803	191	7	amount	amount	NOUN
bam-4803	191	8	of	of	ADP
bam-4803	191	9	detergent	detergent	NOUN
bam-4803	191	10	have	have	AUX
bam-4803	191	11	been	be	AUX
bam-4803	191	12	used	use	VERB
bam-4803	191	13	in	in	ADP
bam-4803	191	14	other	other	ADJ
bam-4803	191	15	imaging	imaging	NOUN
bam-4803	191	16	projects	project	NOUN
bam-4803	191	17	to	to	PART
bam-4803	191	18	reduce	reduce	VERB
bam-4803	191	19	preferred	preferred	ADJ
bam-4803	191	20	orientation	orientation	NOUN
bam-4803	191	21	.	.	PUNCT
bam-4803	192	1	7	7	NUM
bam-4803	192	2	another	another	DET
bam-4803	192	3	approach	approach	NOUN
bam-4803	192	4	is	be	AUX
bam-4803	192	5	the	the	DET
bam-4803	192	6	use	use	NOUN
bam-4803	192	7	of	of	ADP
bam-4803	192	8	short	short	ADJ
bam-4803	192	9	-	-	PUNCT
bam-4803	192	10	chain	chain	NOUN
bam-4803	192	11	phospholipids	phospholipid	NOUN
bam-4803	192	12	,	,	PUNCT
bam-4803	192	13	such	such	ADJ
bam-4803	192	14	as	as	ADP
bam-4803	192	15	dhpc	dhpc	NOUN
bam-4803	192	16	,	,	PUNCT
bam-4803	192	17	that	that	PRON
bam-4803	192	18	are	be	AUX
bam-4803	192	19	believed	believe	VERB
bam-4803	192	20	to	to	PART
bam-4803	192	21	not	not	PART
bam-4803	192	22	strongly	strongly	ADV
bam-4803	192	23	interact	interact	VERB
bam-4803	192	24	with	with	ADP
bam-4803	192	25	the	the	DET
bam-4803	192	26	membrane	membrane	NOUN
bam-4803	192	27	protein	protein	NOUN
bam-4803	192	28	but	but	CCONJ
bam-4803	192	29	can	can	AUX
bam-4803	192	30	form	form	VERB
bam-4803	192	31	a	a	DET
bam-4803	192	32	monolayer	monolayer	NOUN
bam-4803	192	33	at	at	ADP
bam-4803	192	34	the	the	DET
bam-4803	192	35	air	air	NOUN
bam-4803	192	36	-	-	PUNCT
bam-4803	192	37	water	water	NOUN
bam-4803	192	38	interface	interface	NOUN
bam-4803	192	39	to	to	PART
bam-4803	192	40	reduce	reduce	VERB
bam-4803	192	41	surface	surface	NOUN
bam-4803	192	42	interactions	interaction	NOUN
bam-4803	192	43	with	with	ADP
bam-4803	192	44	the	the	DET
bam-4803	192	45	apol	apol	NOUN
bam-4803	192	46	.	.	PUNCT
bam-4803	193	1	78,79	78,79	VERB
bam-4803	193	2	such	such	ADJ
bam-4803	193	3	monolayers	monolayer	NOUN
bam-4803	193	4	represent	represent	VERB
bam-4803	193	5	a	a	DET
bam-4803	193	6	very	very	ADV
bam-4803	193	7	low	low	ADJ
bam-4803	193	8	volumetric	volumetric	NOUN
bam-4803	193	9	concentration	concentration	NOUN
bam-4803	193	10	and	and	CCONJ
bam-4803	193	11	should	should	AUX
bam-4803	193	12	not	not	PART
bam-4803	193	13	have	have	VERB
bam-4803	193	14	any	any	DET
bam-4803	193	15	significant	significant	ADJ
bam-4803	193	16	impact	impact	NOUN
bam-4803	193	17	on	on	ADP
bam-4803	193	18	image	image	NOUN
bam-4803	193	19	contrast	contrast	NOUN
bam-4803	193	20	.	.	PUNCT
bam-4803	194	1	increased	increase	VERB
bam-4803	194	2	image	image	NOUN
bam-4803	194	3	contrast	contrast	NOUN
bam-4803	194	4	in	in	ADP
bam-4803	194	5	the	the	DET
bam-4803	194	6	presence	presence	NOUN
bam-4803	194	7	of	of	ADP
bam-4803	194	8	apol	apol	NOUN
bam-4803	194	9	is	be	AUX
bam-4803	194	10	particularly	particularly	ADV
bam-4803	194	11	critical	critical	ADJ
bam-4803	194	12	in	in	ADP
bam-4803	194	13	the	the	DET
bam-4803	194	14	pursuit	pursuit	NOUN
bam-4803	194	15	of	of	ADP
bam-4803	194	16	high	high	ADJ
bam-4803	194	17	-	-	PUNCT
bam-4803	194	18	resolution	resolution	NOUN
bam-4803	194	19	structures	structure	NOUN
bam-4803	194	20	of	of	ADP
bam-4803	194	21	membrane	membrane	NOUN
bam-4803	194	22	proteins	protein	NOUN
bam-4803	194	23	in	in	ADP
bam-4803	194	24	general	general	ADJ
bam-4803	194	25	.	.	PUNCT
bam-4803	195	1	in	in	ADP
bam-4803	195	2	cryoem	cryoem	NOUN
bam-4803	195	3	images	image	NOUN
bam-4803	195	4	of	of	ADP
bam-4803	195	5	apol	apol	NOUN
bam-4803	195	6	bound	bind	VERB
bam-4803	195	7	ryr1	ryr1	NOUN
bam-4803	195	8	,	,	PUNCT
bam-4803	195	9	the	the	DET
bam-4803	195	10	background	background	NOUN
bam-4803	195	11	observed	observe	VERB
bam-4803	195	12	is	be	AUX
bam-4803	195	13	dramatically	dramatically	ADV
bam-4803	195	14	lower	low	ADJ
bam-4803	195	15	than	than	ADP
bam-4803	195	16	in	in	ADP
bam-4803	195	17	images	image	NOUN
bam-4803	195	18	with	with	ADP
bam-4803	195	19	detergent	detergent	NOUN
bam-4803	195	20	present	present	NOUN
bam-4803	195	21	.	.	PUNCT
bam-4803	196	1	the	the	DET
bam-4803	196	2	apol	apol	NOUN
bam-4803	196	3	bound	bind	VERB
bam-4803	196	4	ryr1	ryr1	NOUN
bam-4803	196	5	data	datum	NOUN
bam-4803	196	6	has	have	VERB
bam-4803	196	7	~26	~26	NUM
bam-4803	196	8	%	%	NOUN
bam-4803	196	9	contrast	contrast	NOUN
bam-4803	196	10	at	at	ADP
bam-4803	196	11	5	5	NUM
bam-4803	196	12	-	-	SYM
bam-4803	196	13	10	10	NUM
bam-4803	196	14	å	å	NOUN
bam-4803	196	15	resolution	resolution	NOUN
bam-4803	196	16	as	as	SCONJ
bam-4803	196	17	compared	compare	VERB
bam-4803	196	18	to	to	ADP
bam-4803	196	19	0	0	NUM
bam-4803	196	20	-	-	SYM
bam-4803	196	21	2	2	NUM
bam-4803	196	22	%	%	NOUN
bam-4803	196	23	in	in	ADP
bam-4803	196	24	the	the	DET
bam-4803	196	25	presence	presence	NOUN
bam-4803	196	26	of	of	ADP
bam-4803	196	27	chaps	chap	NOUN
bam-4803	196	28	using	use	VERB
bam-4803	196	29	a	a	DET
bam-4803	196	30	traditional	traditional	ADJ
bam-4803	196	31	ccd	ccd	NOUN
bam-4803	196	32	detector	detector	NOUN
bam-4803	196	33	.	.	PUNCT
bam-4803	197	1	advancements	advancement	NOUN
bam-4803	197	2	in	in	ADP
bam-4803	197	3	cryo	cryo	PROPN
bam-4803	197	4	-	-	PUNCT
bam-4803	197	5	em	em	PROPN
bam-4803	197	6	imaging	image	VERB
bam-4803	197	7	detectors	detector	NOUN
bam-4803	197	8	have	have	AUX
bam-4803	197	9	led	lead	VERB
bam-4803	197	10	to	to	ADP
bam-4803	197	11	an	an	DET
bam-4803	197	12	increased	increase	VERB
bam-4803	197	13	contrast	contrast	NOUN
bam-4803	197	14	in	in	ADP
bam-4803	197	15	at	at	ADP
bam-4803	197	16	high	high	ADJ
bam-4803	197	17	to	to	ADP
bam-4803	197	18	intermediate	intermediate	ADJ
bam-4803	197	19	resolutions	resolution	NOUN
bam-4803	197	20	and	and	CCONJ
bam-4803	197	21	are	be	AUX
bam-4803	197	22	one	one	NUM
bam-4803	197	23	of	of	ADP
bam-4803	197	24	the	the	DET
bam-4803	197	25	reasons	reason	NOUN
bam-4803	197	26	the	the	DET
bam-4803	197	27	field	field	NOUN
bam-4803	197	28	is	be	AUX
bam-4803	197	29	seeing	see	VERB
bam-4803	197	30	an	an	DET
bam-4803	197	31	increase	increase	NOUN
bam-4803	197	32	of	of	ADP
bam-4803	197	33	near	near	ADJ
bam-4803	197	34	-	-	PUNCT
bam-4803	197	35	atomic	atomic	ADJ
bam-4803	197	36	resolution	resolution	NOUN
bam-4803	197	37	structures	structure	NOUN
bam-4803	197	38	solved	solve	VERB
bam-4803	197	39	by	by	ADP
bam-4803	197	40	cryo	cryo	PROPN
bam-4803	197	41	-	-	PUNCT
bam-4803	197	42	em	em	PROPN
bam-4803	197	43	.	.	PUNCT
bam-4803	197	44	with	with	ADP
bam-4803	197	45	new	new	ADJ
bam-4803	197	46	technology	technology	NOUN
bam-4803	197	47	in	in	ADP
bam-4803	197	48	place	place	NOUN
bam-4803	197	49	,	,	PUNCT
bam-4803	197	50	a	a	DET
bam-4803	197	51	more	more	ADV
bam-4803	197	52	stabilized	stabilize	VERB
bam-4803	197	53	protein	protein	NOUN
bam-4803	197	54	with	with	ADP
bam-4803	197	55	higher	high	ADJ
bam-4803	197	56	image	image	NOUN
bam-4803	197	57	contrast	contrast	NOUN
bam-4803	197	58	in	in	ADP
bam-4803	197	59	detergent	detergent	NOUN
bam-4803	197	60	-	-	PUNCT
bam-4803	197	61	free	free	ADJ
bam-4803	197	62	solution	solution	NOUN
bam-4803	197	63	will	will	AUX
bam-4803	197	64	greatly	greatly	ADV
bam-4803	197	65	benefit	benefit	VERB
bam-4803	197	66	the	the	DET
bam-4803	197	67	structural	structural	ADJ
bam-4803	197	68	studies	study	NOUN
bam-4803	197	69	of	of	ADP
bam-4803	197	70	the	the	DET
bam-4803	197	71	ryr1	ryr1	PROPN
bam-4803	197	72	channel	channel	NOUN
bam-4803	197	73	complex	complex	NOUN
bam-4803	197	74	.	.	PUNCT
bam-4803	198	1	in	in	ADP
bam-4803	198	2	order	order	NOUN
bam-4803	198	3	to	to	PART
bam-4803	198	4	address	address	VERB
bam-4803	198	5	the	the	DET
bam-4803	198	6	structure	structure	NOUN
bam-4803	198	7	-	-	PUNCT
bam-4803	198	8	function	function	NOUN
bam-4803	198	9	relationship	relationship	NOUN
bam-4803	198	10	using	use	VERB
bam-4803	198	11	cryo	cryo	PROPN
bam-4803	198	12	-	-	PUNCT
bam-4803	198	13	em	em	PROPN
bam-4803	198	14	,	,	PUNCT
bam-4803	198	15	it	it	PRON
bam-4803	198	16	is	be	AUX
bam-4803	198	17	important	important	ADJ
bam-4803	198	18	that	that	SCONJ
bam-4803	198	19	proteins	protein	NOUN
bam-4803	198	20	are	be	AUX
bam-4803	198	21	assessed	assess	VERB
bam-4803	198	22	for	for	ADP
bam-4803	198	23	their	their	PRON
bam-4803	198	24	functionality	functionality	NOUN
bam-4803	198	25	in	in	ADP
bam-4803	198	26	solution	solution	NOUN
bam-4803	198	27	,	,	PUNCT
bam-4803	198	28	when	when	SCONJ
bam-4803	198	29	possible	possible	ADJ
bam-4803	198	30	.	.	PUNCT
bam-4803	199	1	we	we	PRON
bam-4803	199	2	have	have	AUX
bam-4803	199	3	tested	test	VERB
bam-4803	199	4	the	the	DET
bam-4803	199	5	functionality	functionality	NOUN
bam-4803	199	6	of	of	ADP
bam-4803	199	7	ryr1	ryr1	NOUN
bam-4803	199	8	/	/	SYM
bam-4803	199	9	a835	a835	PROPN
bam-4803	199	10	complexes	complex	NOUN
bam-4803	199	11	by	by	ADP
bam-4803	199	12	[	[	PUNCT
bam-4803	199	13	3	3	NUM
bam-4803	199	14	h]-ryanodine	h]-ryanodine	NOUN
bam-4803	199	15	binding	bind	VERB
bam-4803	199	16	assay	assay	NOUN
bam-4803	199	17	,	,	PUNCT
bam-4803	199	18	which	which	PRON
bam-4803	199	19	yielded	yield	VERB
bam-4803	199	20	a	a	DET
bam-4803	199	21	kd	kd	NOUN
bam-4803	199	22	of	of	ADP
bam-4803	199	23	1.99	1.99	NUM
bam-4803	199	24	nm	nm	NOUN
bam-4803	199	25	and	and	CCONJ
bam-4803	199	26	bmax	bmax	VERB
bam-4803	199	27	of	of	ADP
bam-4803	199	28	60.4	60.4	NUM
bam-4803	199	29	pmol	pmol	NOUN
bam-4803	199	30	/	/	SYM
bam-4803	199	31	mg	mg	PROPN
bam-4803	199	32	,	,	PUNCT
bam-4803	199	33	similar	similar	ADJ
bam-4803	199	34	to	to	ADP
bam-4803	199	35	that	that	PRON
bam-4803	199	36	of	of	ADP
bam-4803	199	37	purified	purified	ADJ
bam-4803	199	38	ryr1	ryr1	NOUN
bam-4803	199	39	in	in	ADP
bam-4803	199	40	the	the	DET
bam-4803	199	41	presence	presence	NOUN
bam-4803	199	42	of	of	ADP
bam-4803	199	43	0.4	0.4	NUM
bam-4803	199	44	%	%	NOUN
bam-4803	199	45	chaps	chap	NOUN
bam-4803	199	46	(	(	PUNCT
bam-4803	199	47	fig	fig	NOUN
bam-4803	199	48	.	.	PUNCT
bam-4803	199	49	4	4	NUM
bam-4803	199	50	)	)	PUNCT
bam-4803	199	51	.	.	PUNCT
bam-4803	200	1	80,81	80,81	NUM
bam-4803	200	2	since	since	ADV
bam-4803	200	3	,	,	PUNCT
bam-4803	200	4	ryanodine	ryanodine	PROPN
bam-4803	200	5	binds	bind	VERB
bam-4803	200	6	specifically	specifically	ADV
bam-4803	200	7	and	and	CCONJ
bam-4803	200	8	with	with	ADP
bam-4803	200	9	high	high	ADJ
bam-4803	200	10	affinity	affinity	NOUN
bam-4803	200	11	preferentially	preferentially	ADV
bam-4803	200	12	to	to	ADP
bam-4803	200	13	the	the	DET
bam-4803	200	14	open	open	ADJ
bam-4803	200	15	state	state	NOUN
bam-4803	200	16	of	of	ADP
bam-4803	200	17	the	the	DET
bam-4803	200	18	intact	intact	ADJ
bam-4803	200	19	ryr1	ryr1	NOUN
bam-4803	200	20	channel	channel	NOUN
bam-4803	200	21	,	,	PUNCT
bam-4803	200	22	this	this	DET
bam-4803	200	23	radioligand	radioligand	NOUN
bam-4803	200	24	binding	bind	VERB
bam-4803	200	25	assay	assay	NOUN
bam-4803	200	26	can	can	AUX
bam-4803	200	27	be	be	AUX
bam-4803	200	28	considered	consider	VERB
bam-4803	200	29	as	as	ADP
bam-4803	200	30	an	an	DET
bam-4803	200	31	indirect	indirect	ADJ
bam-4803	200	32	measure	measure	NOUN
bam-4803	200	33	of	of	ADP
bam-4803	200	34	channel	channel	NOUN
bam-4803	200	35	activation	activation	NOUN
bam-4803	200	36	and	and	CCONJ
bam-4803	200	37	indication	indication	NOUN
bam-4803	200	38	of	of	ADP
bam-4803	200	39	its	its	PRON
bam-4803	200	40	tetrameric	tetrameric	ADJ
bam-4803	200	41	structure	structure	NOUN
bam-4803	200	42	.	.	PUNCT
bam-4803	201	1	30	30	NUM
bam-4803	202	1	it	it	PRON
bam-4803	202	2	is	be	AUX
bam-4803	202	3	evident	evident	ADJ
bam-4803	202	4	by	by	ADP
bam-4803	202	5	recent	recent	ADJ
bam-4803	202	6	structural	structural	ADJ
bam-4803	202	7	studies	study	NOUN
bam-4803	202	8	by	by	ADP
bam-4803	202	9	cryo	cryo	PROPN
bam-4803	202	10	-	-	PUNCT
bam-4803	202	11	em	em	PRON
bam-4803	202	12	that	that	DET
bam-4803	202	13	apols	apol	NOUN
bam-4803	202	14	have	have	VERB
bam-4803	202	15	a	a	DET
bam-4803	202	16	major	major	ADJ
bam-4803	202	17	advantage	advantage	NOUN
bam-4803	202	18	in	in	ADP
bam-4803	202	19	stabilizing	stabilize	VERB
bam-4803	202	20	membrane	membrane	NOUN
bam-4803	202	21	proteins	protein	NOUN
bam-4803	202	22	in	in	ADP
bam-4803	202	23	aqueous	aqueous	ADJ
bam-4803	202	24	solution	solution	NOUN
bam-4803	202	25	,	,	PUNCT
bam-4803	202	26	reducing	reduce	VERB
bam-4803	202	27	detergent	detergent	NOUN
bam-4803	202	28	-	-	PUNCT
bam-4803	202	29	based	base	VERB
bam-4803	202	30	background	background	NOUN
bam-4803	202	31	in	in	ADP
bam-4803	202	32	cryo	cryo	NOUN
bam-4803	202	33	-	-	PUNCT
bam-4803	202	34	imaging	imaging	NOUN
bam-4803	202	35	and	and	CCONJ
bam-4803	202	36	maintaining	maintain	VERB
bam-4803	202	37	functionality	functionality	NOUN
bam-4803	202	38	.	.	PUNCT
bam-4803	203	1	determining	determine	VERB
bam-4803	203	2	the	the	DET
bam-4803	203	3	structure	structure	NOUN
bam-4803	203	4	of	of	ADP
bam-4803	203	5	many	many	ADJ
bam-4803	203	6	challenging	challenging	ADJ
bam-4803	203	7	membrane	membrane	NOUN
bam-4803	203	8	proteins	protein	NOUN
bam-4803	203	9	,	,	PUNCT
bam-4803	203	10	like	like	ADP
bam-4803	203	11	the	the	DET
bam-4803	203	12	ca	ca	NOUN
bam-4803	203	13	2	2	NUM
bam-4803	203	14	+	+	NOUN
bam-4803	203	15	release	release	NOUN
bam-4803	203	16	channel	channel	NOUN
bam-4803	203	17	,	,	PUNCT
bam-4803	203	18	by	by	ADP
bam-4803	203	19	cryo	cryo	NOUN
bam-4803	203	20	-	-	PUNCT
bam-4803	203	21	em	em	PRON
bam-4803	203	22	will	will	AUX
bam-4803	203	23	no	no	ADV
bam-4803	203	24	doubt	doubt	ADV
bam-4803	203	25	be	be	AUX
bam-4803	203	26	well	well	ADV
bam-4803	203	27	served	serve	VERB
bam-4803	203	28	by	by	ADP
bam-4803	203	29	detergent	detergent	NOUN
bam-4803	203	30	alternatives	alternative	NOUN
bam-4803	203	31	like	like	ADP
bam-4803	203	32	apols	apol	NOUN
bam-4803	203	33	.	.	PUNCT
bam-4803	204	1	future	future	ADJ
bam-4803	204	2	outlook	outlook	NOUN
bam-4803	204	3	while	while	SCONJ
bam-4803	204	4	much	much	ADJ
bam-4803	204	5	progress	progress	NOUN
bam-4803	204	6	has	have	AUX
bam-4803	204	7	been	be	AUX
bam-4803	204	8	made	make	VERB
bam-4803	204	9	in	in	ADP
bam-4803	204	10	the	the	DET
bam-4803	204	11	elucidation	elucidation	NOUN
bam-4803	204	12	of	of	ADP
bam-4803	204	13	the	the	DET
bam-4803	204	14	structure	structure	NOUN
bam-4803	204	15	of	of	ADP
bam-4803	204	16	ryr1	ryr1	NOUN
bam-4803	204	17	by	by	ADP
bam-4803	204	18	cryo	cryo	PROPN
bam-4803	204	19	-	-	PUNCT
bam-4803	204	20	em	em	PROPN
bam-4803	204	21	and	and	CCONJ
bam-4803	204	22	x	x	NOUN
bam-4803	204	23	-	-	NOUN
bam-4803	204	24	ray	ray	NOUN
bam-4803	204	25	crystallography	crystallography	NOUN
bam-4803	204	26	,	,	PUNCT
bam-4803	204	27	there	there	PRON
bam-4803	204	28	is	be	VERB
bam-4803	204	29	still	still	ADV
bam-4803	204	30	a	a	DET
bam-4803	204	31	need	need	NOUN
bam-4803	204	32	to	to	PART
bam-4803	204	33	pursue	pursue	VERB
bam-4803	204	34	atomic	atomic	ADJ
bam-4803	204	35	level	level	NOUN
bam-4803	204	36	resolution	resolution	NOUN
bam-4803	204	37	structures	structure	NOUN
bam-4803	204	38	of	of	ADP
bam-4803	204	39	the	the	DET
bam-4803	204	40	channel	channel	NOUN
bam-4803	204	41	in	in	ADP
bam-4803	204	42	order	order	NOUN
bam-4803	204	43	to	to	PART
bam-4803	204	44	fully	fully	ADV
bam-4803	204	45	understand	understand	VERB
bam-4803	204	46	channel	channel	NOUN
bam-4803	204	47	function	function	NOUN
bam-4803	204	48	.	.	PUNCT
bam-4803	205	1	cryo	cryo	PROPN
bam-4803	205	2	-	-	PUNCT
bam-4803	205	3	em	em	PRON
bam-4803	205	4	and	and	CCONJ
bam-4803	205	5	image	image	NOUN
bam-4803	205	6	processing	processing	NOUN
bam-4803	205	7	technology	technology	NOUN
bam-4803	205	8	,	,	PUNCT
bam-4803	205	9	with	with	ADP
bam-4803	205	10	their	their	PRON
bam-4803	205	11	continuing	continue	VERB
bam-4803	205	12	advancements	advancement	NOUN
bam-4803	205	13	,	,	PUNCT
bam-4803	205	14	are	be	AUX
bam-4803	205	15	in	in	ADP
bam-4803	205	16	their	their	PRON
bam-4803	205	17	prime	prime	NOUN
bam-4803	205	18	to	to	PART
bam-4803	205	19	be	be	AUX
bam-4803	205	20	able	able	ADJ
bam-4803	205	21	to	to	PART
bam-4803	205	22	produced	produce	VERB
bam-4803	205	23	atomic	atomic	ADJ
bam-4803	205	24	-	-	PUNCT
bam-4803	205	25	level	level	NOUN
bam-4803	205	26	details	detail	NOUN
bam-4803	205	27	in	in	ADP
bam-4803	205	28	density	density	NOUN
bam-4803	205	29	maps	map	NOUN
bam-4803	205	30	that	that	PRON
bam-4803	205	31	can	can	AUX
bam-4803	205	32	be	be	AUX
bam-4803	205	33	directly	directly	ADV
bam-4803	205	34	utilized	utilize	VERB
bam-4803	205	35	for	for	ADP
bam-4803	205	36	de	de	X
bam-4803	205	37	novo	novo	PROPN
bam-4803	205	38	model	model	NOUN
bam-4803	205	39	building	building	NOUN
bam-4803	205	40	.	.	PUNCT
bam-4803	206	1	cryospecimen	cryospeciman	NOUN
bam-4803	206	2	preparation	preparation	NOUN
bam-4803	206	3	,	,	PUNCT
bam-4803	206	4	especially	especially	ADV
bam-4803	206	5	for	for	ADP
bam-4803	206	6	membrane	membrane	ADJ
bam-4803	206	7	proteins	protein	NOUN
bam-4803	206	8	,	,	PUNCT
bam-4803	206	9	now	now	ADV
bam-4803	206	10	appears	appear	VERB
bam-4803	206	11	to	to	PART
bam-4803	206	12	be	be	AUX
bam-4803	206	13	a	a	DET
bam-4803	206	14	major	major	ADJ
bam-4803	206	15	bottleneck	bottleneck	NOUN
bam-4803	206	16	in	in	ADP
bam-4803	206	17	the	the	DET
bam-4803	206	18	cryo	cryo	NOUN
bam-4803	206	19	-	-	PUNCT
bam-4803	206	20	em	em	PRON
bam-4803	206	21	experiment	experiment	NOUN
bam-4803	206	22	.	.	PUNCT
bam-4803	207	1	it	it	PRON
bam-4803	207	2	is	be	AUX
bam-4803	207	3	a	a	DET
bam-4803	207	4	formidable	formidable	ADJ
bam-4803	207	5	challenge	challenge	NOUN
bam-4803	207	6	to	to	PART
bam-4803	207	7	produce	produce	VERB
bam-4803	207	8	biochemically	biochemically	ADV
bam-4803	207	9	homogeneous	homogeneous	ADJ
bam-4803	207	10	and	and	CCONJ
bam-4803	207	11	structurally	structurally	ADV
bam-4803	207	12	stable	stable	ADJ
bam-4803	207	13	large	large	ADJ
bam-4803	207	14	membrane	membrane	NOUN
bam-4803	207	15	protein	protein	NOUN
bam-4803	207	16	complexes	complex	NOUN
bam-4803	207	17	like	like	ADP
bam-4803	207	18	the	the	DET
bam-4803	207	19	ca	ca	NOUN
bam-4803	207	20	2	2	NUM
bam-4803	207	21	+	+	NOUN
bam-4803	207	22	release	release	NOUN
bam-4803	207	23	channel	channel	NOUN
bam-4803	207	24	and	and	CCONJ
bam-4803	207	25	is	be	AUX
bam-4803	207	26	compounded	compound	VERB
bam-4803	207	27	by	by	ADP
bam-4803	207	28	the	the	DET
bam-4803	207	29	structural	structural	ADJ
bam-4803	207	30	flexibility	flexibility	NOUN
bam-4803	207	31	inherent	inherent	ADJ
bam-4803	207	32	to	to	ADP
bam-4803	207	33	ryrs	ryr	NOUN
bam-4803	207	34	complex	complex	ADJ
bam-4803	207	35	allosteric	allosteric	ADJ
bam-4803	207	36	regulation	regulation	NOUN
bam-4803	207	37	.	.	PUNCT
bam-4803	208	1	the	the	DET
bam-4803	208	2	successful	successful	ADJ
bam-4803	208	3	use	use	NOUN
bam-4803	208	4	of	of	ADP
bam-4803	208	5	detergent	detergent	NOUN
bam-4803	208	6	alternatives	alternative	NOUN
bam-4803	208	7	,	,	PUNCT
bam-4803	208	8	like	like	ADP
bam-4803	208	9	apols	apol	NOUN
bam-4803	208	10	,	,	PUNCT
bam-4803	208	11	will	will	AUX
bam-4803	208	12	undoubtedly	undoubtedly	ADV
bam-4803	208	13	energize	energize	VERB
bam-4803	208	14	the	the	DET
bam-4803	208	15	field	field	NOUN
bam-4803	208	16	of	of	ADP
bam-4803	208	17	the	the	DET
bam-4803	208	18	membrane	membrane	NOUN
bam-4803	208	19	protein	protein	NOUN
bam-4803	208	20	structural	structural	ADJ
bam-4803	208	21	biology	biology	NOUN
bam-4803	208	22	by	by	ADP
bam-4803	208	23	cryo	cryo	PROPN
bam-4803	208	24	-	-	PUNCT
bam-4803	208	25	em	em	PROPN
bam-4803	208	26	.	.	PUNCT
bam-4803	209	1	the	the	DET
bam-4803	209	2	momentum	momentum	NOUN
bam-4803	209	3	in	in	ADP
bam-4803	209	4	single	single	ADJ
bam-4803	209	5	-	-	PUNCT
bam-4803	209	6	particle	particle	NOUN
bam-4803	209	7	cryo	cryo	NOUN
bam-4803	209	8	-	-	PUNCT
bam-4803	209	9	em	em	PRON
bam-4803	209	10	is	be	AUX
bam-4803	209	11	currently	currently	ADV
bam-4803	209	12	remarkable	remarkable	ADJ
bam-4803	209	13	and	and	CCONJ
bam-4803	209	14	near	near	ADJ
bam-4803	209	15	-	-	PUNCT
bam-4803	209	16	atomic	atomic	ADJ
bam-4803	209	17	resolution	resolution	NOUN
bam-4803	209	18	structures	structure	NOUN
bam-4803	209	19	of	of	ADP
bam-4803	209	20	the	the	DET
bam-4803	209	21	entire	entire	ADJ
bam-4803	209	22	ca	ca	NOUN
bam-4803	209	23	2	2	NUM
bam-4803	209	24	+	+	NOUN
bam-4803	209	25	release	release	NOUN
bam-4803	209	26	channel	channel	NOUN
bam-4803	209	27	should	should	AUX
bam-4803	209	28	be	be	AUX
bam-4803	209	29	expected	expect	VERB
bam-4803	209	30	in	in	ADP
bam-4803	209	31	near	near	ADJ
bam-4803	209	32	future	future	NOUN
bam-4803	209	33	.	.	PUNCT
bam-4803	210	1	note	note	NOUN
bam-4803	210	2	added	add	VERB
bam-4803	210	3	at	at	ADP
bam-4803	210	4	proof	proof	NOUN
bam-4803	210	5	while	while	SCONJ
bam-4803	210	6	this	this	DET
bam-4803	210	7	review	review	NOUN
bam-4803	210	8	was	be	AUX
bam-4803	210	9	in	in	ADP
bam-4803	210	10	press	press	NOUN
bam-4803	210	11	,	,	PUNCT
bam-4803	210	12	three	three	NUM
bam-4803	210	13	new	new	ADJ
bam-4803	210	14	cryo	cryo	NOUN
bam-4803	210	15	-	-	PUNCT
bam-4803	210	16	em	em	PRON
bam-4803	210	17	structures	structure	NOUN
bam-4803	210	18	of	of	ADP
bam-4803	210	19	ryr1	ryr1	NOUN
bam-4803	210	20	were	be	AUX
bam-4803	210	21	deposited	deposit	VERB
bam-4803	210	22	to	to	ADP
bam-4803	210	23	em	em	PRON
bam-4803	210	24	data	data	PROPN
bam-4803	210	25	bank	bank	PROPN
bam-4803	210	26	(	(	PUNCT
bam-4803	210	27	emdb	emdb	PROPN
bam-4803	210	28	i	i	PROPN
bam-4803	210	29	d	d	PROPN
bam-4803	210	30	:	:	PUNCT
bam-4803	210	31	2751	2751	NUM
bam-4803	210	32	,	,	PUNCT
bam-4803	210	33	2752	2752	NUM
bam-4803	210	34	,	,	PUNCT
bam-4803	210	35	6106	6106	NUM
bam-4803	210	36	,	,	PUNCT
bam-4803	210	37	6107	6107	NUM
bam-4803	210	38	and	and	CCONJ
bam-4803	210	39	2807	2807	NUM
bam-4803	210	40	)	)	PUNCT
bam-4803	210	41	.	.	PUNCT
bam-4803	211	1	the	the	DET
bam-4803	211	2	structures	structure	NOUN
bam-4803	211	3	were	be	AUX
bam-4803	211	4	determined	determine	VERB
bam-4803	211	5	at	at	ADP
bam-4803	211	6	4.8	4.8	NUM
bam-4803	211	7	-	-	SYM
bam-4803	211	8	8	8	NUM
bam-4803	211	9	å	å	PROPN
bam-4803	211	10	resolutions	resolution	NOUN
bam-4803	211	11	based	base	VERB
bam-4803	211	12	on	on	ADP
bam-4803	211	13	the	the	DET
bam-4803	211	14	“	"	PUNCT
bam-4803	211	15	gold	gold	NOUN
bam-4803	211	16	-	-	PUNCT
bam-4803	211	17	standard	standard	NOUN
bam-4803	211	18	”	"	PUNCT
bam-4803	211	19	criteria	criterion	NOUN
bam-4803	211	20	.	.	PUNCT
bam-4803	212	1	56	56	NUM
bam-4803	212	2	fig	fig	NOUN
bam-4803	212	3	4	4	NUM
bam-4803	212	4	.	.	PUNCT
bam-4803	213	1	scatchard	scatchard	ADJ
bam-4803	213	2	analysis	analysis	NOUN
bam-4803	213	3	of	of	ADP
bam-4803	213	4	[	[	PUNCT
bam-4803	213	5	3	3	NUM
bam-4803	213	6	h]-ryanodine	h]-ryanodine	NOUN
bam-4803	213	7	binding	bind	VERB
bam-4803	213	8	to	to	ADP
bam-4803	213	9	ryr1	ryr1	NOUN
bam-4803	213	10	:	:	PUNCT
bam-4803	213	11	in	in	ADP
bam-4803	213	12	skeletal	skeletal	ADJ
bam-4803	213	13	muscle	muscle	NOUN
bam-4803	213	14	sr	sr	PROPN
bam-4803	213	15	membranes	membrane	NOUN
bam-4803	213	16	(	(	PUNCT
bam-4803	213	17	●	●	NOUN
bam-4803	213	18	)	)	PUNCT
bam-4803	213	19	,	,	PUNCT
bam-4803	213	20	purified	purified	ADJ
bam-4803	213	21	ryr1	ryr1	NOUN
bam-4803	213	22	bound	bind	VERB
bam-4803	213	23	to	to	ADP
bam-4803	213	24	chaps	chap	NOUN
bam-4803	213	25	(	(	PUNCT
bam-4803	213	26	▲	▲	PUNCT
bam-4803	213	27	)	)	PUNCT
bam-4803	213	28	and	and	CCONJ
bam-4803	213	29	800	800	NUM
bam-4803	213	30	purified	purified	ADJ
bam-4803	213	31	ryr1	ryr1	NOUN
bam-4803	213	32	in	in	ADP
bam-4803	213	33	complex	complex	NOUN
bam-4803	213	34	with	with	ADP
bam-4803	213	35	a8	a8	PROPN
bam-4803	213	36	-	-	PUNCT
bam-4803	213	37	35	35	NUM
bam-4803	213	38	(	(	PUNCT
bam-4803	213	39	■	■	NOUN
bam-4803	213	40	)	)	PUNCT
bam-4803	213	41	.	.	PUNCT
bam-4803	214	1	linear	linear	PROPN
bam-4803	214	2	fitting	fitting	ADJ
bam-4803	214	3	yielded	yield	VERB
bam-4803	214	4	kd	kd	PROPN
bam-4803	214	5	of	of	ADP
bam-4803	214	6	1.99	1.99	NUM
bam-4803	214	7	nm	nm	NOUN
bam-4803	214	8	and	and	CCONJ
bam-4803	214	9	bmax	bmax	VERB
bam-4803	214	10	of	of	ADP
bam-4803	214	11	60.4	60.4	NUM
bam-4803	214	12	pmol	pmol	NOUN
bam-4803	214	13	/	/	SYM
bam-4803	214	14	mg	mg	ADP
bam-4803	214	15	of	of	ADP
bam-4803	214	16	protein	protein	NOUN
bam-4803	214	17	for	for	ADP
bam-4803	214	18	ryr1	ryr1	NOUN
bam-4803	214	19	/	/	SYM
bam-4803	214	20	a8	a8	PROPN
bam-4803	214	21	-	-	PUNCT
bam-4803	214	22	35	35	NUM
bam-4803	214	23	,	,	PUNCT
bam-4803	214	24	and	and	CCONJ
bam-4803	214	25	kd	kd	PROPN
bam-4803	214	26	of	of	ADP
bam-4803	214	27	41.27	41.27	NUM
bam-4803	214	28	nm	nm	NOUN
bam-4803	214	29	and	and	CCONJ
bam-4803	214	30	bmax	bmax	NOUN
bam-4803	214	31	of	of	ADP
bam-4803	214	32	3.07	3.07	NUM
bam-4803	214	33	pmol	pmol	NOUN
bam-4803	214	34	/	/	SYM
bam-4803	214	35	mg	mg	NOUN
bam-4803	214	36	for	for	ADP
bam-4803	214	37	ryr1	ryr1	NOUN
bam-4803	214	38	/	/	SYM
bam-4803	214	39	chaps	chap	NOUN
bam-4803	214	40	and	and	CCONJ
bam-4803	214	41	kd	kd	PROPN
bam-4803	214	42	of	of	ADP
bam-4803	214	43	2.54	2.54	NUM
bam-4803	214	44	nm	nm	NOUN
bam-4803	214	45	and	and	CCONJ
bam-4803	214	46	bmax	bmax	VERB
bam-4803	214	47	of	of	ADP
bam-4803	214	48	27.9	27.9	NUM
bam-4803	214	49	pmol	pmol	NOUN
bam-4803	214	50	/	/	SYM
bam-4803	214	51	mg	mg	PROPN
bam-4803	214	52	for	for	ADP
bam-4803	214	53	sr	sr	PROPN
bam-4803	214	54	membranes	membrane	NOUN
bam-4803	214	55	in	in	ADP
bam-4803	214	56	high	high	ADJ
bam-4803	214	57	ca	ca	NOUN
bam-4803	214	58	2	2	NUM
bam-4803	214	59	+	+	NUM
bam-4803	214	60	conditions	condition	NOUN
bam-4803	214	61	(	(	PUNCT
bam-4803	214	62	200μm	200μm	NOUN
bam-4803	214	63	ca	ca	NOUN
bam-4803	214	64	2	2	NUM
bam-4803	214	65	+	+	CCONJ
bam-4803	214	66	)	)	PUNCT
bam-4803	214	67	,	,	PUNCT
bam-4803	214	68	indicating	indicate	VERB
bam-4803	214	69	that	that	SCONJ
bam-4803	214	70	the	the	DET
bam-4803	214	71	high	high	ADJ
bam-4803	214	72	-	-	PUNCT
bam-4803	214	73	affinity	affinity	NOUN
bam-4803	214	74	binding	bind	VERB
bam-4803	214	75	site	site	NOUN
bam-4803	214	76	for	for	ADP
bam-4803	214	77	ryanodine	ryanodine	NOUN
bam-4803	214	78	is	be	AUX
bam-4803	214	79	retained	retain	VERB
bam-4803	214	80	in	in	ADP
bam-4803	214	81	ryr1	ryr1	NOUN
bam-4803	214	82	/	/	SYM
bam-4803	214	83	apol	apol	NOUN
bam-4803	214	84	and	and	CCONJ
bam-4803	214	85	similar	similar	ADJ
bam-4803	214	86	to	to	ADP
bam-4803	214	87	that	that	PRON
bam-4803	214	88	of	of	ADP
bam-4803	214	89	ryr1	ryr1	NOUN
bam-4803	214	90	embedded	embed	VERB
bam-4803	214	91	within	within	ADP
bam-4803	214	92	the	the	DET
bam-4803	214	93	sr	sr	PROPN
bam-4803	214	94	membrane	membrane	NOUN
bam-4803	214	95	.	.	PUNCT
bam-4803	215	1	single	single	ADJ
bam-4803	215	2	-	-	PUNCT
bam-4803	215	3	particle	particle	NOUN
bam-4803	215	4	cryo	cryo	NOUN
bam-4803	215	5	-	-	PUNCT
bam-4803	215	6	em	em	PRON
bam-4803	215	7	of	of	ADP
bam-4803	215	8	the	the	DET
bam-4803	215	9	ryanodine	ryanodine	PROPN
bam-4803	215	10	receptor	receptor	NOUN
bam-4803	215	11	channel	channel	PROPN
bam-4803	215	12	eur	eur	PROPN
bam-4803	215	13	j	j	PROPN
bam-4803	215	14	transl	transl	PROPN
bam-4803	215	15	myol	myol	PROPN
bam-4803	215	16	basic	basic	ADJ
bam-4803	215	17	appl	appl	NOUN
bam-4803	215	18	myol	myol	NOUN
bam-4803	215	19	2015	2015	NUM
bam-4803	215	20	;	;	PUNCT
bam-4803	215	21	25	25	NUM
bam-4803	215	22	(	(	PUNCT
bam-4803	215	23	1	1	NUM
bam-4803	215	24	):	):	PUNCT
bam-4803	215	25	35	35	NUM
bam-4803	215	26	-	-	SYM
bam-4803	215	27	48	48	NUM
bam-4803	215	28	45	45	NUM
bam-4803	215	29	acknowledgement	acknowledgement	NOUN
bam-4803	215	30	this	this	DET
bam-4803	215	31	research	research	NOUN
bam-4803	215	32	is	be	AUX
bam-4803	215	33	supported	support	VERB
bam-4803	215	34	by	by	ADP
bam-4803	215	35	grants	grant	NOUN
bam-4803	215	36	from	from	ADP
bam-4803	215	37	the	the	DET
bam-4803	215	38	national	national	PROPN
bam-4803	215	39	institutes	institutes	PROPN
bam-4803	215	40	of	of	ADP
bam-4803	215	41	health	health	PROPN
bam-4803	215	42	(	(	PUNCT
bam-4803	215	43	r01gm072804	r01gm072804	NOUN
bam-4803	215	44	,	,	PUNCT
bam-4803	215	45	r21ar063255	r21ar063255	PROPN
bam-4803	215	46	,	,	PUNCT
bam-4803	215	47	p41rr002250	p41rr002250	NOUN
bam-4803	215	48	and	and	CCONJ
bam-4803	215	49	s10od016279	s10od016279	NOUN
bam-4803	215	50	)	)	PUNCT
bam-4803	215	51	,	,	PUNCT
bam-4803	215	52	the	the	DET
bam-4803	215	53	american	american	PROPN
bam-4803	215	54	heart	heart	PROPN
bam-4803	215	55	association	association	PROPN
bam-4803	215	56	(	(	PUNCT
bam-4803	215	57	14rnt1980029	14rnt1980029	NUM
bam-4803	215	58	)	)	PUNCT
bam-4803	215	59	and	and	CCONJ
bam-4803	215	60	the	the	DET
bam-4803	215	61	muscular	muscular	ADJ
bam-4803	215	62	dystrophy	dystrophy	NOUN
bam-4803	215	63	association	association	NOUN
bam-4803	215	64	(	(	PUNCT
bam-4803	215	65	295138	295138	NUM
bam-4803	215	66	)	)	PUNCT
bam-4803	215	67	.	.	PUNCT
bam-4803	216	1	contributions	contribution	NOUN
bam-4803	216	2	of	of	ADP
bam-4803	216	3	authors	author	NOUN
bam-4803	216	4	mrb	mrb	PROPN
bam-4803	216	5	,	,	PUNCT
bam-4803	216	6	gf	gf	PROPN
bam-4803	216	7	and	and	CCONJ
bam-4803	216	8	is	be	AUX
bam-4803	216	9	prepared	prepare	VERB
bam-4803	216	10	the	the	DET
bam-4803	216	11	manuscript	manuscript	NOUN
bam-4803	216	12	and	and	CCONJ
bam-4803	216	13	performed	perform	VERB
bam-4803	216	14	all	all	DET
bam-4803	216	15	work	work	NOUN
bam-4803	216	16	.	.	PUNCT
bam-4803	217	1	corresponding	correspond	VERB
bam-4803	217	2	author	author	PROPN
bam-4803	217	3	irina	irina	PROPN
bam-4803	217	4	i.	i.	PROPN
bam-4803	217	5	serysheva	serysheva	PROPN
bam-4803	217	6	,	,	PUNCT
bam-4803	217	7	department	department	NOUN
bam-4803	217	8	of	of	ADP
bam-4803	217	9	biochemistry	biochemistry	NOUN
bam-4803	217	10	and	and	CCONJ
bam-4803	217	11	molecular	molecular	ADJ
bam-4803	217	12	biology	biology	NOUN
bam-4803	217	13	,	,	PUNCT
bam-4803	217	14	the	the	DET
bam-4803	217	15	university	university	PROPN
bam-4803	217	16	of	of	ADP
bam-4803	217	17	texas	texas	PROPN
bam-4803	217	18	medical	medical	PROPN
bam-4803	217	19	school	school	PROPN
bam-4803	217	20	,	,	PUNCT
bam-4803	217	21	6431	6431	NUM
bam-4803	217	22	fannin	fannin	PROPN
bam-4803	217	23	,	,	PUNCT
bam-4803	217	24	msb	msb	PROPN
bam-4803	217	25	6.219	6.219	NUM
bam-4803	217	26	,	,	PUNCT
bam-4803	217	27	houston	houston	PROPN
bam-4803	217	28	,	,	PUNCT
bam-4803	217	29	tx	tx	PROPN
bam-4803	217	30	77030	77030	NUM
bam-4803	217	31	u.	u.	PROPN
bam-4803	217	32	s.	s.	PROPN
bam-4803	217	33	a.	a.	PROPN
bam-4803	217	34	tel	tel	PROPN
bam-4803	217	35	.	.	PUNCT
bam-4803	217	36	:	:	PUNCT
bam-4803	218	1	713	713	NUM
bam-4803	218	2	-	-	SYM
bam-4803	218	3	500	500	NUM
bam-4803	218	4	-	-	PUNCT
bam-4803	218	5	5523	5523	NUM
bam-4803	218	6	,	,	PUNCT
bam-4803	218	7	fax	fax	NOUN
bam-4803	218	8	:	:	PUNCT
bam-4803	218	9	713	713	NUM
bam-4803	218	10	-	-	PUNCT
bam-4803	218	11	500	500	NUM
bam-4803	218	12	-	-	PUNCT
bam-4803	218	13	6297	6297	NUM
bam-4803	218	14	e‐mail	e‐mail	NUM
bam-4803	218	15	:	:	PUNCT
bam-4803	218	16	irina.i.serysheva@uth.tmc.edu	irina.i.serysheva@uth.tmc.edu	NOUN
bam-4803	218	17	e	e	NOUN
bam-4803	218	18	-	-	NOUN
bam-4803	218	19	mails	mail	NOUN
bam-4803	218	20	of	of	ADP
bam-4803	218	21	co	co	NOUN
bam-4803	218	22	-	-	NOUN
bam-4803	218	23	authors	author	NOUN
bam-4803	218	24	mariah	mariah	PROPN
bam-4803	218	25	r.	r.	PROPN
bam-4803	218	26	baker	baker	PROPN
bam-4803	218	27	:	:	PUNCT
bam-4803	218	28	mariah.r.baker@uth.tmc.edu	mariah.r.baker@uth.tmc.edu	PROPN
bam-4803	218	29	guizhen	guizhen	PROPN
bam-4803	218	30	fan	fan	PROPN
bam-4803	218	31	:	:	PUNCT
bam-4803	219	1	guizhen.fan@uth.tmc.edu	guizhen.fan@uth.tmc.edu	NOUN
bam-4803	219	2	references	reference	NOUN
bam-4803	219	3	1	1	NUM
bam-4803	219	4	.	.	PUNCT
bam-4803	220	1	baker	baker	PROPN
bam-4803	220	2	ml	ml	PROPN
bam-4803	220	3	,	,	PUNCT
bam-4803	220	4	baker	baker	PROPN
bam-4803	220	5	mr	mr	PROPN
bam-4803	220	6	,	,	PUNCT
bam-4803	220	7	cong	cong	NOUN
bam-4803	220	8	y.	y.	PROPN
bam-4803	220	9	computational	computational	ADJ
bam-4803	220	10	methods	method	NOUN
bam-4803	220	11	for	for	ADP
bam-4803	220	12	interpretation	interpretation	NOUN
bam-4803	220	13	of	of	ADP
bam-4803	220	14	em	em	PRON
bam-4803	220	15	maps	map	VERB
bam-4803	220	16	at	at	ADP
bam-4803	220	17	subnanometer	subnanometer	ADJ
bam-4803	220	18	resolution	resolution	NOUN
bam-4803	220	19	.	.	PUNCT
bam-4803	221	1	els	els	PROPN
bam-4803	221	2	.	.	PUNCT
bam-4803	222	1	chichester	chichester	PROPN
bam-4803	222	2	:	:	PUNCT
bam-4803	222	3	johnwiley&sons	johnwiley&sons	PROPN
bam-4803	222	4	,	,	PUNCT
bam-4803	222	5	ltd	ltd	PROPN
bam-4803	222	6	;	;	PUNCT
bam-4803	222	7	2012	2012	NUM
bam-4803	222	8	.	.	PUNCT
bam-4803	223	1	2	2	X
bam-4803	223	2	.	.	X
bam-4803	223	3	cong	cong	PROPN
bam-4803	223	4	y	y	PROPN
bam-4803	223	5	,	,	PUNCT
bam-4803	223	6	ludtke	ludtke	NOUN
bam-4803	223	7	sj	sj	VERB
bam-4803	223	8	.	.	PUNCT
bam-4803	223	9	single	single	ADJ
bam-4803	223	10	particle	particle	NOUN
bam-4803	223	11	analysis	analysis	NOUN
bam-4803	223	12	at	at	ADP
bam-4803	223	13	high	high	ADJ
bam-4803	223	14	resolution	resolution	NOUN
bam-4803	223	15	.	.	PUNCT
bam-4803	224	1	meth	meth	PROPN
bam-4803	224	2	enzymol	enzymol	PROPN
bam-4803	224	3	2010;482:211	2010;482:211	NUM
bam-4803	224	4	-	-	PROPN
bam-4803	224	5	35	35	NUM
bam-4803	224	6	.	.	PUNCT
bam-4803	224	7	3	3	X
bam-4803	224	8	.	.	X
bam-4803	224	9	lau	lau	PROPN
bam-4803	224	10	wc	wc	PROPN
bam-4803	224	11	,	,	PUNCT
bam-4803	224	12	rubinstein	rubinstein	PROPN
bam-4803	224	13	jl	jl	PROPN
bam-4803	224	14	.	.	PUNCT
bam-4803	225	1	single	single	ADJ
bam-4803	225	2	particle	particle	NOUN
bam-4803	225	3	electron	electron	NOUN
bam-4803	225	4	microscopy	microscopy	NOUN
bam-4803	225	5	.	.	PUNCT
bam-4803	226	1	methods	method	NOUN
bam-4803	226	2	in	in	ADP
bam-4803	226	3	molecular	molecular	ADJ
bam-4803	226	4	biology	biology	NOUN
bam-4803	226	5	.	.	PUNCT
bam-4803	227	1	2013;955:401	2013;955:401	NUM
bam-4803	227	2	-	-	SYM
bam-4803	227	3	26	26	NUM
bam-4803	227	4	.	.	PUNCT
bam-4803	228	1	4	4	X
bam-4803	228	2	.	.	X
bam-4803	228	3	liao	liao	PROPN
bam-4803	228	4	m	m	PROPN
bam-4803	228	5	,	,	PUNCT
bam-4803	228	6	cao	cao	PROPN
bam-4803	228	7	e	e	PROPN
bam-4803	228	8	,	,	PUNCT
bam-4803	228	9	julius	julius	PROPN
bam-4803	228	10	d	d	PROPN
bam-4803	228	11	,	,	PUNCT
bam-4803	228	12	cheng	cheng	PROPN
bam-4803	228	13	y.	y.	PROPN
bam-4803	228	14	single	single	ADJ
bam-4803	228	15	particle	particle	PROPN
bam-4803	228	16	electron	electron	PROPN
bam-4803	228	17	cryo	cryo	NOUN
bam-4803	228	18	-	-	PUNCT
bam-4803	228	19	microscopy	microscopy	NOUN
bam-4803	228	20	of	of	ADP
bam-4803	228	21	a	a	DET
bam-4803	228	22	mammalian	mammalian	ADJ
bam-4803	228	23	ion	ion	NOUN
bam-4803	228	24	channel	channel	NOUN
bam-4803	228	25	.	.	PUNCT
bam-4803	229	1	current	current	ADJ
bam-4803	229	2	opinion	opinion	NOUN
bam-4803	229	3	in	in	ADP
bam-4803	229	4	structural	structural	ADJ
bam-4803	229	5	biology	biology	NOUN
bam-4803	229	6	2014;27c:1	2014;27c:1	NUM
bam-4803	229	7	-	-	SYM
bam-4803	229	8	7	7	NUM
bam-4803	229	9	.	.	NOUN
bam-4803	229	10	5	5	NUM
bam-4803	229	11	.	.	PUNCT
bam-4803	229	12	wang	wang	PROPN
bam-4803	229	13	l	l	PROPN
bam-4803	229	14	,	,	PUNCT
bam-4803	229	15	sigworth	sigworth	ADJ
bam-4803	229	16	fj	fj	PROPN
bam-4803	229	17	.	.	PUNCT
bam-4803	229	18	structure	structure	NOUN
bam-4803	229	19	of	of	ADP
bam-4803	229	20	the	the	DET
bam-4803	229	21	bk	bk	PROPN
bam-4803	229	22	potassium	potassium	NOUN
bam-4803	229	23	channel	channel	NOUN
bam-4803	229	24	in	in	ADP
bam-4803	229	25	a	a	DET
bam-4803	229	26	lipid	lipid	NOUN
bam-4803	229	27	membrane	membrane	NOUN
bam-4803	229	28	from	from	ADP
bam-4803	229	29	electron	electron	NOUN
bam-4803	229	30	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	229	31	.	.	PUNCT
bam-4803	230	1	nature	nature	NOUN
bam-4803	230	2	2009;461(7261):292	2009;461(7261):292	NUM
bam-4803	230	3	-	-	SYM
bam-4803	230	4	5	5	NUM
bam-4803	230	5	.	.	NOUN
bam-4803	230	6	6	6	NUM
bam-4803	230	7	.	.	PUNCT
bam-4803	231	1	cong	cong	PROPN
bam-4803	231	2	y	y	PROPN
bam-4803	231	3	,	,	PUNCT
bam-4803	231	4	baker	baker	PROPN
bam-4803	231	5	ml	ml	PROPN
bam-4803	231	6	,	,	PUNCT
bam-4803	231	7	jakana	jakana	PROPN
bam-4803	231	8	j	j	PROPN
bam-4803	231	9	,	,	PUNCT
bam-4803	231	10	et	et	PROPN
bam-4803	231	11	al	al	PROPN
bam-4803	231	12	.	.	PROPN
bam-4803	232	1	4.0å	4.0å	NUM
bam-4803	232	2	resolution	resolution	NOUN
bam-4803	232	3	cryo	cryo	NOUN
bam-4803	232	4	-	-	PUNCT
bam-4803	232	5	em	em	PRON
bam-4803	232	6	structure	structure	NOUN
bam-4803	232	7	of	of	ADP
bam-4803	232	8	the	the	DET
bam-4803	232	9	mammalian	mammalian	ADJ
bam-4803	232	10	chaperonin	chaperonin	PROPN
bam-4803	232	11	tric	tric	PROPN
bam-4803	232	12	/	/	SYM
bam-4803	232	13	cct	cct	PROPN
bam-4803	232	14	reveals	reveal	VERB
bam-4803	232	15	its	its	PRON
bam-4803	232	16	unique	unique	ADJ
bam-4803	232	17	subunit	subunit	NOUN
bam-4803	232	18	arrangement	arrangement	NOUN
bam-4803	232	19	.	.	PUNCT
bam-4803	233	1	proc	proc	PROPN
bam-4803	233	2	natl	natl	PROPN
bam-4803	233	3	acad	acad	PROPN
bam-4803	233	4	sci	sci	PROPN
bam-4803	233	5	u	u	PROPN
bam-4803	233	6	s	s	PROPN
bam-4803	233	7	a	a	DET
bam-4803	233	8	2010;107:4967	2010;107:4967	NUM
bam-4803	233	9	-	-	SYM
bam-4803	233	10	72	72	NUM
bam-4803	233	11	.	.	PUNCT
bam-4803	234	1	7	7	NUM
bam-4803	234	2	.	.	X
bam-4803	235	1	zhang	zhang	PROPN
bam-4803	235	2	j	j	PROPN
bam-4803	235	3	,	,	PUNCT
bam-4803	235	4	baker	baker	PROPN
bam-4803	235	5	ml	ml	PROPN
bam-4803	235	6	,	,	PUNCT
bam-4803	235	7	schroder	schroder	PROPN
bam-4803	235	8	gf	gf	PROPN
bam-4803	235	9	,	,	PUNCT
bam-4803	235	10	et	et	PROPN
bam-4803	235	11	al	al	PROPN
bam-4803	235	12	.	.	PUNCT
bam-4803	235	13	mechanism	mechanism	NOUN
bam-4803	235	14	of	of	ADP
bam-4803	235	15	folding	fold	VERB
bam-4803	235	16	chamber	chamber	NOUN
bam-4803	235	17	closure	closure	NOUN
bam-4803	235	18	in	in	ADP
bam-4803	235	19	a	a	DET
bam-4803	235	20	group	group	NOUN
bam-4803	235	21	ii	ii	PROPN
bam-4803	235	22	chaperonin	chaperonin	PROPN
bam-4803	235	23	.	.	PUNCT
bam-4803	236	1	nature	nature	NOUN
bam-4803	236	2	2010;463(7279):379	2010;463(7279):379	NUM
bam-4803	236	3	-	-	SYM
bam-4803	236	4	83	83	NUM
bam-4803	236	5	.	.	PUNCT
bam-4803	236	6	8	8	NUM
bam-4803	236	7	.	.	PUNCT
bam-4803	237	1	zhang	zhang	PROPN
bam-4803	237	2	x	x	PROPN
bam-4803	237	3	,	,	PUNCT
bam-4803	237	4	settembre	settembre	PROPN
bam-4803	237	5	e	e	PROPN
bam-4803	237	6	,	,	PUNCT
bam-4803	237	7	xu	xu	PROPN
bam-4803	237	8	c	c	X
bam-4803	237	9	,	,	PUNCT
bam-4803	237	10	et	et	PROPN
bam-4803	237	11	al	al	PROPN
bam-4803	237	12	.	.	PROPN
bam-4803	237	13	near	near	ADP
bam-4803	237	14	-	-	PUNCT
bam-4803	237	15	atomic	atomic	ADJ
bam-4803	237	16	resolution	resolution	NOUN
bam-4803	237	17	using	use	VERB
bam-4803	237	18	electron	electron	NOUN
bam-4803	237	19	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	237	20	and	and	CCONJ
bam-4803	237	21	single	single	ADJ
bam-4803	237	22	-	-	PUNCT
bam-4803	237	23	particle	particle	NOUN
bam-4803	237	24	reconstruction	reconstruction	NOUN
bam-4803	237	25	.	.	PUNCT
bam-4803	238	1	proc	proc	PROPN
bam-4803	238	2	natl	natl	PROPN
bam-4803	238	3	acad	acad	PROPN
bam-4803	238	4	sci	sci	PROPN
bam-4803	238	5	u	u	PROPN
bam-4803	238	6	s	s	PROPN
bam-4803	238	7	a	a	DET
bam-4803	238	8	2008;105:1867	2008;105:1867	NUM
bam-4803	238	9	-	-	SYM
bam-4803	238	10	72	72	NUM
bam-4803	238	11	.	.	NOUN
bam-4803	239	1	9	9	NUM
bam-4803	239	2	.	.	X
bam-4803	239	3	ludtke	ludtke	PROPN
bam-4803	239	4	sj	sj	PROPN
bam-4803	239	5	,	,	PUNCT
bam-4803	239	6	baker	baker	PROPN
bam-4803	239	7	ml	ml	PROPN
bam-4803	239	8	,	,	PUNCT
bam-4803	239	9	chen	chen	PROPN
bam-4803	239	10	dh	dh	PROPN
bam-4803	239	11	,	,	PUNCT
bam-4803	239	12	et	et	PROPN
bam-4803	239	13	al	al	PROPN
bam-4803	239	14	.	.	PROPN
bam-4803	239	15	de	de	PROPN
bam-4803	239	16	novo	novo	PROPN
bam-4803	239	17	backbone	backbone	NOUN
bam-4803	239	18	trace	trace	NOUN
bam-4803	239	19	of	of	ADP
bam-4803	239	20	groel	groel	NOUN
bam-4803	239	21	from	from	ADP
bam-4803	239	22	single	single	ADJ
bam-4803	239	23	particle	particle	NOUN
bam-4803	239	24	electron	electron	NOUN
bam-4803	239	25	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	239	26	.	.	PUNCT
bam-4803	240	1	structure	structure	NOUN
bam-4803	240	2	2008;16:4418	2008;16:4418	PROPN
bam-4803	240	3	.	.	PUNCT
bam-4803	240	4	10	10	NUM
bam-4803	240	5	.	.	PUNCT
bam-4803	240	6	yu	yu	PROPN
bam-4803	241	1	x	x	PROPN
bam-4803	241	2	,	,	PUNCT
bam-4803	241	3	jin	jin	PROPN
bam-4803	241	4	l	l	PROPN
bam-4803	241	5	,	,	PUNCT
bam-4803	241	6	zhou	zhou	PROPN
bam-4803	241	7	zh	zh	PROPN
bam-4803	241	8	.	.	PROPN
bam-4803	242	1	3.88	3.88	NUM
bam-4803	242	2	å	å	PROPN
bam-4803	242	3	structure	structure	NOUN
bam-4803	242	4	of	of	ADP
bam-4803	242	5	cytoplasmic	cytoplasmic	ADJ
bam-4803	242	6	polyhedrosis	polyhedrosis	ADJ
bam-4803	242	7	virus	virus	NOUN
bam-4803	242	8	by	by	ADP
bam-4803	242	9	cryo	cryo	NOUN
bam-4803	242	10	-	-	PUNCT
bam-4803	242	11	electron	electron	NOUN
bam-4803	242	12	microscopy	microscopy	NOUN
bam-4803	242	13	.	.	PUNCT
bam-4803	243	1	nature	nature	NOUN
bam-4803	243	2	2008;453(7193):415	2008;453(7193):415	NUM
bam-4803	243	3	-	-	SYM
bam-4803	243	4	9	9	NUM
bam-4803	243	5	.	.	NOUN
bam-4803	243	6	11	11	NUM
bam-4803	243	7	.	.	PUNCT
bam-4803	244	1	jiang	jiang	PROPN
bam-4803	244	2	w	w	PROPN
bam-4803	244	3	,	,	PUNCT
bam-4803	244	4	baker	baker	PROPN
bam-4803	244	5	ml	ml	PROPN
bam-4803	244	6	,	,	PUNCT
bam-4803	244	7	jakana	jakana	PROPN
bam-4803	244	8	j	j	PROPN
bam-4803	244	9	,	,	PUNCT
bam-4803	244	10	et	et	PROPN
bam-4803	244	11	al	al	PROPN
bam-4803	244	12	.	.	PROPN
bam-4803	244	13	backbone	backbone	NOUN
bam-4803	244	14	structure	structure	NOUN
bam-4803	244	15	of	of	ADP
bam-4803	244	16	the	the	DET
bam-4803	244	17	infectious	infectious	ADJ
bam-4803	244	18	epsilon15	epsilon15	NOUN
bam-4803	244	19	virus	virus	PROPN
bam-4803	244	20	capsid	capsid	PROPN
bam-4803	244	21	revealed	reveal	VERB
bam-4803	244	22	by	by	ADP
bam-4803	244	23	electron	electron	NOUN
bam-4803	244	24	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	244	25	.	.	PUNCT
bam-4803	245	1	nature	nature	NOUN
bam-4803	245	2	2008;451(7182):1130	2008;451(7182):1130	NUM
bam-4803	245	3	-	-	SYM
bam-4803	245	4	4	4	NUM
bam-4803	245	5	.	.	NUM
bam-4803	245	6	12	12	NUM
bam-4803	245	7	.	.	PUNCT
bam-4803	246	1	cao	cao	PROPN
bam-4803	246	2	e	e	PROPN
bam-4803	246	3	,	,	PUNCT
bam-4803	246	4	liao	liao	PROPN
bam-4803	246	5	m	m	PROPN
bam-4803	246	6	,	,	PUNCT
bam-4803	246	7	cheng	cheng	PROPN
bam-4803	246	8	y	y	PROPN
bam-4803	246	9	,	,	PUNCT
bam-4803	246	10	julius	julius	PROPN
bam-4803	246	11	d.	d.	PROPN
bam-4803	246	12	trpv1	trpv1	PROPN
bam-4803	246	13	structures	structure	NOUN
bam-4803	246	14	in	in	ADP
bam-4803	246	15	distinct	distinct	ADJ
bam-4803	246	16	conformations	conformation	NOUN
bam-4803	246	17	reveal	reveal	VERB
bam-4803	246	18	activation	activation	NOUN
bam-4803	246	19	mechanisms	mechanism	NOUN
bam-4803	246	20	.	.	PUNCT
bam-4803	247	1	nature	nature	NOUN
bam-4803	247	2	2013;504(7478):113	2013;504(7478):113	NUM
bam-4803	247	3	-	-	SYM
bam-4803	247	4	8	8	NUM
bam-4803	247	5	.	.	NOUN
bam-4803	247	6	13	13	NUM
bam-4803	247	7	.	.	PUNCT
bam-4803	248	1	liao	liao	PROPN
bam-4803	248	2	m	m	PROPN
bam-4803	248	3	,	,	PUNCT
bam-4803	248	4	cao	cao	PROPN
bam-4803	248	5	e	e	PROPN
bam-4803	248	6	,	,	PUNCT
bam-4803	248	7	julius	julius	PROPN
bam-4803	248	8	d	d	PROPN
bam-4803	248	9	,	,	PUNCT
bam-4803	248	10	cheng	cheng	PROPN
bam-4803	248	11	y.	y.	PROPN
bam-4803	248	12	structure	structure	NOUN
bam-4803	248	13	of	of	ADP
bam-4803	248	14	the	the	DET
bam-4803	248	15	trpv1	trpv1	NOUN
bam-4803	248	16	ion	ion	NOUN
bam-4803	248	17	channel	channel	NOUN
bam-4803	248	18	determined	determine	VERB
bam-4803	248	19	by	by	ADP
bam-4803	248	20	electron	electron	NOUN
bam-4803	248	21	cryo	cryo	NOUN
bam-4803	248	22	-	-	PUNCT
bam-4803	248	23	microscopy	microscopy	NOUN
bam-4803	248	24	.	.	PUNCT
bam-4803	249	1	nature	nature	NOUN
bam-4803	249	2	2013;504(7478):107	2013;504(7478):107	NUM
bam-4803	249	3	-	-	SYM
bam-4803	249	4	12	12	NUM
bam-4803	249	5	.	.	PUNCT
bam-4803	249	6	14	14	NUM
bam-4803	249	7	.	.	PUNCT
bam-4803	250	1	lu	lu	PROPN
bam-4803	250	2	p	p	PROPN
bam-4803	250	3	,	,	PUNCT
bam-4803	250	4	bai	bai	PROPN
bam-4803	250	5	xc	xc	PROPN
bam-4803	250	6	,	,	PUNCT
bam-4803	250	7	ma	ma	PROPN
bam-4803	250	8	d	d	PROPN
bam-4803	250	9	,	,	PUNCT
bam-4803	250	10	xie	xie	PROPN
bam-4803	250	11	t	t	PROPN
bam-4803	250	12	,	,	PUNCT
bam-4803	250	13	yan	yan	PROPN
bam-4803	250	14	c	c	X
bam-4803	250	15	,	,	PUNCT
bam-4803	250	16	sun	sun	PROPN
bam-4803	250	17	l	l	PROPN
bam-4803	250	18	,	,	PUNCT
bam-4803	250	19	et	et	PROPN
bam-4803	250	20	al	al	PROPN
bam-4803	250	21	.	.	PROPN
bam-4803	251	1	three	three	NUM
bam-4803	251	2	-	-	PUNCT
bam-4803	251	3	dimensional	dimensional	ADJ
bam-4803	251	4	structure	structure	NOUN
bam-4803	251	5	of	of	ADP
bam-4803	251	6	human	human	ADJ
bam-4803	251	7	gammasecretase	gammasecretase	PROPN
bam-4803	251	8	.	.	PUNCT
bam-4803	252	1	nature	nature	NOUN
bam-4803	252	2	2014;512(7513):166	2014;512(7513):166	NUM
bam-4803	252	3	-	-	SYM
bam-4803	252	4	70	70	NUM
bam-4803	252	5	.	.	PUNCT
bam-4803	252	6	15	15	NUM
bam-4803	252	7	.	.	PUNCT
bam-4803	253	1	bai	bai	PROPN
bam-4803	253	2	xc	xc	PROPN
bam-4803	253	3	,	,	PUNCT
bam-4803	253	4	fernandez	fernandez	PROPN
bam-4803	253	5	is	be	AUX
bam-4803	253	6	,	,	PUNCT
bam-4803	253	7	mcmullan	mcmullan	PROPN
bam-4803	253	8	g	g	PROPN
bam-4803	253	9	,	,	PUNCT
bam-4803	253	10	scheres	schere	VERB
bam-4803	253	11	sh	sh	PROPN
bam-4803	253	12	.	.	PROPN
bam-4803	253	13	ribosome	ribosome	PROPN
bam-4803	253	14	structures	structure	NOUN
bam-4803	253	15	to	to	ADP
bam-4803	253	16	near	near	ADJ
bam-4803	253	17	-	-	PUNCT
bam-4803	253	18	atomic	atomic	ADJ
bam-4803	253	19	resolution	resolution	NOUN
bam-4803	253	20	from	from	ADP
bam-4803	253	21	thirty	thirty	NUM
bam-4803	253	22	thousand	thousand	NUM
bam-4803	253	23	cryo	cryo	NOUN
bam-4803	253	24	-	-	PUNCT
bam-4803	253	25	em	em	PRON
bam-4803	253	26	particles	particle	NOUN
bam-4803	253	27	.	.	PUNCT
bam-4803	254	1	elife	elife	NOUN
bam-4803	254	2	2013;2	2013;2	NUM
bam-4803	254	3	:	:	PUNCT
bam-4803	254	4	e00461	e00461	PROPN
bam-4803	254	5	.	.	PROPN
bam-4803	254	6	16	16	NUM
bam-4803	254	7	.	.	PUNCT
bam-4803	255	1	li	li	PROPN
bam-4803	255	2	x	x	PROPN
bam-4803	255	3	,	,	PUNCT
bam-4803	255	4	mooney	mooney	PROPN
bam-4803	255	5	p	p	PROPN
bam-4803	255	6	,	,	PUNCT
bam-4803	255	7	zheng	zheng	PROPN
bam-4803	255	8	s	s	PROPN
bam-4803	255	9	,	,	PUNCT
bam-4803	255	10	et	et	PROPN
bam-4803	255	11	al	al	PROPN
bam-4803	255	12	.	.	PROPN
bam-4803	255	13	electron	electron	PROPN
bam-4803	255	14	counting	counting	NOUN
bam-4803	255	15	and	and	CCONJ
bam-4803	255	16	beam	beam	NOUN
bam-4803	255	17	-	-	PUNCT
bam-4803	255	18	induced	induce	VERB
bam-4803	255	19	motion	motion	NOUN
bam-4803	255	20	correction	correction	NOUN
bam-4803	255	21	enable	enable	VERB
bam-4803	255	22	near	near	ADP
bam-4803	255	23	-	-	PUNCT
bam-4803	255	24	atomic	atomic	ADJ
bam-4803	255	25	-	-	PUNCT
bam-4803	255	26	resolution	resolution	NOUN
bam-4803	255	27	single	single	ADJ
bam-4803	255	28	-	-	PUNCT
bam-4803	255	29	particle	particle	NOUN
bam-4803	255	30	cryo	cryo	NOUN
bam-4803	255	31	-	-	PUNCT
bam-4803	255	32	em	em	PROPN
bam-4803	255	33	.	.	PUNCT
bam-4803	256	1	nat	nat	PROPN
bam-4803	256	2	methods	method	NOUN
bam-4803	256	3	2013;10:584	2013;10:584	NOUN
bam-4803	256	4	-	-	PUNCT
bam-4803	256	5	90	90	NUM
bam-4803	256	6	.	.	PUNCT
bam-4803	256	7	17	17	NUM
bam-4803	256	8	.	.	PUNCT
bam-4803	257	1	linke	linke	VERB
bam-4803	257	2	d.	d.	PROPN
bam-4803	257	3	detergents	detergent	NOUN
bam-4803	257	4	:	:	PUNCT
bam-4803	257	5	an	an	DET
bam-4803	257	6	overview	overview	NOUN
bam-4803	257	7	.	.	PUNCT
bam-4803	258	1	meth	meth	NOUN
bam-4803	258	2	enzymol	enzymol	PROPN
bam-4803	258	3	2009;463:603	2009;463:603	PROPN
bam-4803	258	4	-	-	SYM
bam-4803	258	5	17	17	NUM
bam-4803	258	6	.	.	PUNCT
bam-4803	258	7	18	18	NUM
bam-4803	258	8	.	.	PUNCT
bam-4803	259	1	takeshima	takeshima	NOUN
bam-4803	259	2	h	h	PROPN
bam-4803	259	3	,	,	PUNCT
bam-4803	259	4	komazaki	komazaki	PROPN
bam-4803	259	5	s	s	PROPN
bam-4803	259	6	,	,	PUNCT
bam-4803	259	7	hirose	hirose	PROPN
bam-4803	260	1	k	k	PROPN
bam-4803	260	2	,	,	PUNCT
bam-4803	260	3	et	et	PROPN
bam-4803	260	4	al	al	PROPN
bam-4803	260	5	.	.	PUNCT
bam-4803	260	6	embryonic	embryonic	ADJ
bam-4803	260	7	lethality	lethality	NOUN
bam-4803	260	8	and	and	CCONJ
bam-4803	260	9	abnormal	abnormal	ADJ
bam-4803	260	10	cardiac	cardiac	ADJ
bam-4803	260	11	myocytes	myocyte	NOUN
bam-4803	260	12	in	in	ADP
bam-4803	260	13	mice	mouse	NOUN
bam-4803	260	14	lacking	lack	VERB
bam-4803	260	15	ryanodine	ryanodine	NOUN
bam-4803	260	16	receptor	receptor	NOUN
bam-4803	260	17	type	type	NOUN
bam-4803	260	18	2	2	NUM
bam-4803	260	19	.	.	PUNCT
bam-4803	260	20	embo	embo	PROPN
bam-4803	260	21	j	j	PROPN
bam-4803	260	22	1998;17:3309	1998;17:3309	NUM
bam-4803	260	23	-	-	SYM
bam-4803	260	24	16	16	NUM
bam-4803	260	25	.	.	PUNCT
bam-4803	261	1	19	19	NUM
bam-4803	261	2	.	.	PUNCT
bam-4803	261	3	takeshima	takeshima	NOUN
bam-4803	261	4	h	h	PROPN
bam-4803	261	5	,	,	PUNCT
bam-4803	261	6	iino	iino	PROPN
bam-4803	261	7	m	m	PROPN
bam-4803	261	8	,	,	PUNCT
bam-4803	261	9	takekura	takekura	ADJ
bam-4803	261	10	h	h	NOUN
bam-4803	261	11	,	,	PUNCT
bam-4803	261	12	et	et	PROPN
bam-4803	261	13	al	al	PROPN
bam-4803	261	14	.	.	PUNCT
bam-4803	261	15	excitation	excitation	NOUN
bam-4803	261	16	-	-	PUNCT
bam-4803	261	17	contraction	contraction	NOUN
bam-4803	261	18	uncoupling	uncoupling	NOUN
bam-4803	261	19	and	and	CCONJ
bam-4803	261	20	muscular	muscular	ADJ
bam-4803	261	21	degeneration	degeneration	NOUN
bam-4803	261	22	in	in	ADP
bam-4803	261	23	mice	mouse	NOUN
bam-4803	261	24	lacking	lack	VERB
bam-4803	261	25	functional	functional	ADJ
bam-4803	261	26	skeletal	skeletal	ADJ
bam-4803	261	27	muscle	muscle	NOUN
bam-4803	261	28	ryanodine	ryanodine	NOUN
bam-4803	261	29	-	-	PUNCT
bam-4803	261	30	receptor	receptor	NOUN
bam-4803	261	31	gene	gene	NOUN
bam-4803	261	32	.	.	PUNCT
bam-4803	262	1	nature	nature	NOUN
bam-4803	262	2	1994;369(6481):556	1994;369(6481):556	NUM
bam-4803	262	3	-	-	SYM
bam-4803	262	4	9	9	NUM
bam-4803	262	5	.	.	NOUN
bam-4803	262	6	20	20	NUM
bam-4803	262	7	.	.	PUNCT
bam-4803	263	1	lanner	lanner	PROPN
bam-4803	263	2	jt	jt	PROPN
bam-4803	263	3	.	.	PROPN
bam-4803	263	4	ryanodine	ryanodine	PROPN
bam-4803	263	5	receptor	receptor	NOUN
bam-4803	263	6	physiology	physiology	NOUN
bam-4803	263	7	and	and	CCONJ
bam-4803	263	8	its	its	PRON
bam-4803	263	9	role	role	NOUN
bam-4803	263	10	in	in	ADP
bam-4803	263	11	disease	disease	NOUN
bam-4803	263	12	.	.	PUNCT
bam-4803	264	1	adv	adv	PROPN
bam-4803	264	2	exp	exp	NOUN
bam-4803	264	3	med	med	ADJ
bam-4803	264	4	biol	biol	NOUN
bam-4803	264	5	2012;740:21734	2012;740:21734	NUM
bam-4803	264	6	.	.	PUNCT
bam-4803	265	1	21	21	NUM
bam-4803	265	2	.	.	PUNCT
bam-4803	266	1	takeshima	takeshima	NOUN
bam-4803	266	2	h	h	PROPN
bam-4803	266	3	,	,	PUNCT
bam-4803	266	4	nishimura	nishimura	PROPN
bam-4803	266	5	s	s	PROPN
bam-4803	266	6	,	,	PUNCT
bam-4803	266	7	matsumoto	matsumoto	PROPN
bam-4803	266	8	t	t	PROPN
bam-4803	266	9	,	,	PUNCT
bam-4803	266	10	et	et	PROPN
bam-4803	266	11	al	al	PROPN
bam-4803	266	12	.	.	PROPN
bam-4803	266	13	primary	primary	ADJ
bam-4803	266	14	structure	structure	NOUN
bam-4803	266	15	and	and	CCONJ
bam-4803	266	16	expression	expression	NOUN
bam-4803	266	17	from	from	ADP
bam-4803	266	18	complementary	complementary	ADJ
bam-4803	266	19	dna	dna	NOUN
bam-4803	266	20	of	of	ADP
bam-4803	266	21	skeletal	skeletal	ADJ
bam-4803	266	22	muscle	muscle	NOUN
bam-4803	266	23	ryanodine	ryanodine	NOUN
bam-4803	266	24	receptor	receptor	NOUN
bam-4803	266	25	.	.	PUNCT
bam-4803	267	1	nature	nature	NOUN
bam-4803	267	2	1989;339(6224):43945	1989;339(6224):43945	NUM
bam-4803	267	3	.	.	PUNCT
bam-4803	268	1	22	22	NUM
bam-4803	268	2	.	.	PUNCT
bam-4803	269	1	zorzato	zorzato	NUM
bam-4803	269	2	f	f	PROPN
bam-4803	269	3	,	,	PUNCT
bam-4803	269	4	fujii	fujii	PROPN
bam-4803	269	5	j	j	PROPN
bam-4803	269	6	,	,	PUNCT
bam-4803	269	7	otsu	otsu	PROPN
bam-4803	269	8	k	k	PROPN
bam-4803	269	9	,	,	PUNCT
bam-4803	269	10	et	et	PROPN
bam-4803	269	11	al	al	PROPN
bam-4803	269	12	.	.	PROPN
bam-4803	270	1	molecular	molecular	ADJ
bam-4803	270	2	cloning	cloning	NOUN
bam-4803	270	3	of	of	ADP
bam-4803	270	4	cdna	cdna	PROPN
bam-4803	270	5	encoding	encode	VERB
bam-4803	270	6	human	human	ADJ
bam-4803	270	7	and	and	CCONJ
bam-4803	270	8	rabbit	rabbit	NOUN
bam-4803	270	9	forms	form	NOUN
bam-4803	270	10	of	of	ADP
bam-4803	270	11	the	the	DET
bam-4803	270	12	ca	ca	NOUN
bam-4803	270	13	2	2	NUM
bam-4803	270	14	+	+	NOUN
bam-4803	270	15	release	release	NOUN
bam-4803	270	16	channel	channel	NOUN
bam-4803	270	17	(	(	PUNCT
bam-4803	270	18	ryanodine	ryanodine	NOUN
bam-4803	270	19	receptor	receptor	NOUN
bam-4803	270	20	)	)	PUNCT
bam-4803	270	21	of	of	ADP
bam-4803	270	22	skeletal	skeletal	ADJ
bam-4803	270	23	muscle	muscle	NOUN
bam-4803	270	24	sarcoplasmic	sarcoplasmic	NOUN
bam-4803	270	25	reticulum	reticulum	NOUN
bam-4803	270	26	.	.	PUNCT
bam-4803	271	1	j	j	PROPN
bam-4803	271	2	biol	biol	PROPN
bam-4803	271	3	chem	chem	NOUN
bam-4803	271	4	1990;265:2244	1990;265:2244	NUM
bam-4803	271	5	-	-	SYM
bam-4803	271	6	56	56	NUM
bam-4803	271	7	.	.	NOUN
bam-4803	271	8	23	23	NUM
bam-4803	271	9	.	.	PUNCT
bam-4803	272	1	tunwell	tunwell	PROPN
bam-4803	272	2	rea	rea	PROPN
bam-4803	272	3	,	,	PUNCT
bam-4803	272	4	lai	lai	PROPN
bam-4803	272	5	fa	fa	PROPN
bam-4803	272	6	.	.	PROPN
bam-4803	272	7	ryanodine	ryanodine	VERB
bam-4803	272	8	receptor	receptor	NOUN
bam-4803	272	9	expression	expression	NOUN
bam-4803	272	10	in	in	ADP
bam-4803	272	11	the	the	DET
bam-4803	272	12	kidney	kidney	NOUN
bam-4803	272	13	and	and	CCONJ
bam-4803	272	14	a	a	DET
bam-4803	272	15	non	non	ADJ
bam-4803	272	16	-	-	ADJ
bam-4803	272	17	excitable	excitable	ADJ
bam-4803	272	18	kidney	kidney	NOUN
bam-4803	272	19	epithelial	epithelial	ADJ
bam-4803	272	20	cell	cell	NOUN
bam-4803	272	21	.	.	PUNCT
bam-4803	273	1	j	j	PROPN
bam-4803	273	2	biol	biol	PROPN
bam-4803	273	3	chem	chem	NOUN
bam-4803	273	4	1996;271:29583	1996;271:29583	NUM
bam-4803	273	5	-	-	SYM
bam-4803	273	6	8	8	NUM
bam-4803	273	7	.	.	NUM
bam-4803	273	8	24	24	NUM
bam-4803	273	9	.	.	PUNCT
bam-4803	273	10	du	du	PROPN
bam-4803	273	11	gg	gg	PROPN
bam-4803	273	12	,	,	PUNCT
bam-4803	273	13	sandhu	sandhu	PROPN
bam-4803	273	14	b	b	PROPN
bam-4803	273	15	,	,	PUNCT
bam-4803	273	16	khanna	khanna	PROPN
bam-4803	273	17	vk	vk	PROPN
bam-4803	273	18	,	,	PUNCT
bam-4803	273	19	et	et	PROPN
bam-4803	273	20	al	al	PROPN
bam-4803	273	21	.	.	PROPN
bam-4803	273	22	topology	topology	NOUN
bam-4803	273	23	of	of	ADP
bam-4803	273	24	the	the	DET
bam-4803	273	25	ca	ca	NOUN
bam-4803	273	26	2	2	NUM
bam-4803	273	27	+	+	NOUN
bam-4803	273	28	release	release	NOUN
bam-4803	273	29	channel	channel	NOUN
bam-4803	273	30	of	of	ADP
bam-4803	273	31	skeletal	skeletal	ADJ
bam-4803	273	32	muscle	muscle	NOUN
bam-4803	273	33	sarcoplasmic	sarcoplasmic	NOUN
bam-4803	273	34	reticulum	reticulum	NOUN
bam-4803	273	35	(	(	PUNCT
bam-4803	273	36	ryr1	ryr1	NOUN
bam-4803	273	37	)	)	PUNCT
bam-4803	273	38	.	.	PUNCT
bam-4803	274	1	proc	proc	PROPN
bam-4803	274	2	natl	natl	PROPN
bam-4803	274	3	acad	acad	PROPN
bam-4803	274	4	sci	sci	PROPN
bam-4803	274	5	u	u	PROPN
bam-4803	274	6	s	s	PROPN
bam-4803	274	7	a	a	DET
bam-4803	274	8	2002;99:16725	2002;99:16725	NUM
bam-4803	274	9	-	-	SYM
bam-4803	274	10	30	30	NUM
bam-4803	274	11	.	.	PUNCT
bam-4803	275	1	25	25	NUM
bam-4803	275	2	.	.	PUNCT
bam-4803	275	3	ferguson	ferguson	PROPN
bam-4803	275	4	dg	dg	PROPN
bam-4803	275	5	,	,	PUNCT
bam-4803	275	6	schwartz	schwartz	PROPN
bam-4803	275	7	h	h	PROPN
bam-4803	275	8	,	,	PUNCT
bam-4803	275	9	franzini	franzini	PROPN
bam-4803	275	10	-	-	PUNCT
bam-4803	275	11	armstrong	armstrong	PROPN
bam-4803	275	12	c.	c.	PROPN
bam-4803	275	13	subunit	subunit	NOUN
bam-4803	275	14	structure	structure	NOUN
bam-4803	275	15	of	of	ADP
bam-4803	275	16	junctional	junctional	ADJ
bam-4803	275	17	feet	foot	NOUN
bam-4803	275	18	in	in	ADP
bam-4803	275	19	triads	triad	NOUN
bam-4803	275	20	of	of	ADP
bam-4803	275	21	skeletal	skeletal	ADJ
bam-4803	275	22	muscle	muscle	NOUN
bam-4803	275	23	:	:	PUNCT
bam-4803	275	24	a	a	DET
bam-4803	275	25	freeze	freeze	NOUN
bam-4803	275	26	-	-	PUNCT
bam-4803	275	27	drying	dry	VERB
bam-4803	275	28	,	,	PUNCT
bam-4803	275	29	rotaryshadowing	rotaryshadowe	VERB
bam-4803	275	30	study	study	NOUN
bam-4803	275	31	.	.	PUNCT
bam-4803	276	1	j	j	PROPN
bam-4803	276	2	cell	cell	NOUN
bam-4803	276	3	biol	biol	PROPN
bam-4803	276	4	1984;99:173542	1984;99:173542	NUM
bam-4803	276	5	.	.	PUNCT
bam-4803	277	1	mailto:irina.i.serysheva@uth.tmc.edu	mailto:irina.i.serysheva@uth.tmc.edu	PROPN
bam-4803	277	2	mailto:mariah.r.baker@uth.tmc.edu	mailto:mariah.r.baker@uth.tmc.edu	PROPN
bam-4803	277	3	mailto:guizhen.fan@uth.tmc.edu	mailto:guizhen.fan@uth.tmc.edu	PROPN
bam-4803	277	4	single	single	ADJ
bam-4803	277	5	-	-	PUNCT
bam-4803	277	6	particle	particle	NOUN
bam-4803	277	7	cryo	cryo	NOUN
bam-4803	277	8	-	-	PUNCT
bam-4803	277	9	em	em	PRON
bam-4803	277	10	of	of	ADP
bam-4803	277	11	the	the	DET
bam-4803	277	12	ryanodine	ryanodine	PROPN
bam-4803	277	13	receptor	receptor	NOUN
bam-4803	277	14	channel	channel	PROPN
bam-4803	277	15	eur	eur	PROPN
bam-4803	277	16	j	j	PROPN
bam-4803	277	17	transl	transl	PROPN
bam-4803	277	18	myol	myol	PROPN
bam-4803	277	19	basic	basic	ADJ
bam-4803	277	20	appl	appl	NOUN
bam-4803	277	21	myol	myol	NOUN
bam-4803	277	22	2015	2015	NUM
bam-4803	277	23	;	;	PUNCT
bam-4803	277	24	25	25	NUM
bam-4803	277	25	(	(	PUNCT
bam-4803	277	26	1	1	NUM
bam-4803	277	27	):	):	PUNCT
bam-4803	277	28	35	35	NUM
bam-4803	277	29	-	-	SYM
bam-4803	277	30	48	48	NUM
bam-4803	277	31	46	46	NUM
bam-4803	277	32	26	26	NUM
bam-4803	277	33	.	.	PUNCT
bam-4803	278	1	franzini	franzini	PROPN
bam-4803	278	2	-	-	PUNCT
bam-4803	278	3	armstrong	armstrong	PROPN
bam-4803	278	4	c.	c.	PROPN
bam-4803	278	5	structure	structure	NOUN
bam-4803	278	6	of	of	ADP
bam-4803	278	7	sarcoplasmic	sarcoplasmic	ADJ
bam-4803	278	8	reticulum	reticulum	NOUN
bam-4803	278	9	.	.	PUNCT
bam-4803	279	1	federation	federation	NOUN
bam-4803	279	2	proceedings	proceeding	NOUN
bam-4803	279	3	1980;39:24039	1980;39:24039	NUM
bam-4803	279	4	.	.	PUNCT
bam-4803	280	1	27	27	NUM
bam-4803	280	2	.	.	PUNCT
bam-4803	281	1	campbell	campbell	PROPN
bam-4803	281	2	kp	kp	PROPN
bam-4803	281	3	,	,	PUNCT
bam-4803	281	4	franzini	franzini	PROPN
bam-4803	281	5	-	-	PUNCT
bam-4803	281	6	armstrong	armstrong	PROPN
bam-4803	281	7	c	c	PROPN
bam-4803	281	8	,	,	PUNCT
bam-4803	281	9	shamoo	shamoo	ADJ
bam-4803	281	10	ae	ae	PROPN
bam-4803	281	11	.	.	PUNCT
bam-4803	282	1	further	further	ADJ
bam-4803	282	2	characterization	characterization	NOUN
bam-4803	282	3	of	of	ADP
bam-4803	282	4	light	light	NOUN
bam-4803	282	5	and	and	CCONJ
bam-4803	282	6	heavy	heavy	ADJ
bam-4803	282	7	sarcoplasmic	sarcoplasmic	NOUN
bam-4803	282	8	reticulum	reticulum	NOUN
bam-4803	282	9	vesicles	vesicle	NOUN
bam-4803	282	10	.	.	PUNCT
bam-4803	283	1	identification	identification	NOUN
bam-4803	283	2	of	of	ADP
bam-4803	283	3	the	the	DET
bam-4803	283	4	'	'	PUNCT
bam-4803	283	5	sarcoplasmic	sarcoplasmic	ADJ
bam-4803	283	6	reticulum	reticulum	NOUN
bam-4803	283	7	feet	foot	NOUN
bam-4803	283	8	'	'	PUNCT
bam-4803	283	9	associated	associate	VERB
bam-4803	283	10	with	with	ADP
bam-4803	283	11	heavy	heavy	ADJ
bam-4803	283	12	sarcoplasmic	sarcoplasmic	NOUN
bam-4803	283	13	reticulum	reticulum	NOUN
bam-4803	283	14	vesicles	vesicle	NOUN
bam-4803	283	15	.	.	PUNCT
bam-4803	284	1	biochim	biochim	PROPN
bam-4803	284	2	biophys	biophy	NOUN
bam-4803	284	3	acta	acta	VERB
bam-4803	284	4	1980;602:97	1980;602:97	NUM
bam-4803	284	5	-	-	SYM
bam-4803	284	6	116	116	NUM
bam-4803	284	7	.	.	PUNCT
bam-4803	285	1	28	28	NUM
bam-4803	285	2	.	.	PUNCT
bam-4803	286	1	inui	inui	PROPN
bam-4803	286	2	m	m	PROPN
bam-4803	286	3	,	,	PUNCT
bam-4803	286	4	saito	saito	PROPN
bam-4803	286	5	a	a	PRON
bam-4803	286	6	,	,	PUNCT
bam-4803	286	7	fleischer	fleischer	PROPN
bam-4803	286	8	s.	s.	PROPN
bam-4803	286	9	purification	purification	PROPN
bam-4803	286	10	of	of	ADP
bam-4803	286	11	the	the	DET
bam-4803	286	12	ryanodine	ryanodine	NOUN
bam-4803	286	13	receptor	receptor	NOUN
bam-4803	286	14	and	and	CCONJ
bam-4803	286	15	identity	identity	NOUN
bam-4803	286	16	with	with	ADP
bam-4803	286	17	feet	foot	NOUN
bam-4803	286	18	structures	structure	NOUN
bam-4803	286	19	of	of	ADP
bam-4803	286	20	junctional	junctional	ADJ
bam-4803	286	21	terminal	terminal	ADJ
bam-4803	286	22	cisternae	cisternae	NOUN
bam-4803	286	23	of	of	ADP
bam-4803	286	24	sarcoplasmic	sarcoplasmic	ADJ
bam-4803	286	25	reticulum	reticulum	NOUN
bam-4803	286	26	from	from	ADP
bam-4803	286	27	fast	fast	ADJ
bam-4803	286	28	skeletal	skeletal	ADJ
bam-4803	286	29	muscle	muscle	NOUN
bam-4803	286	30	.	.	PUNCT
bam-4803	287	1	j	j	PROPN
bam-4803	287	2	biol	biol	PROPN
bam-4803	287	3	chem	chem	NOUN
bam-4803	287	4	1987;262:1740	1987;262:1740	NOUN
bam-4803	287	5	-	-	SYM
bam-4803	287	6	7	7	NUM
bam-4803	287	7	.	.	NOUN
bam-4803	287	8	29	29	NUM
bam-4803	287	9	.	.	PUNCT
bam-4803	288	1	fleischer	fleischer	PROPN
bam-4803	288	2	s	s	PART
bam-4803	288	3	,	,	PUNCT
bam-4803	288	4	ogunbunmi	ogunbunmi	ADP
bam-4803	288	5	em	em	PRON
bam-4803	288	6	,	,	PUNCT
bam-4803	288	7	dixon	dixon	PROPN
bam-4803	288	8	mc	mc	PROPN
bam-4803	288	9	,	,	PUNCT
bam-4803	288	10	fleer	fleer	NOUN
bam-4803	288	11	ea	ea	NOUN
bam-4803	288	12	.	.	PUNCT
bam-4803	289	1	localization	localization	NOUN
bam-4803	289	2	of	of	ADP
bam-4803	289	3	ca	ca	NOUN
bam-4803	289	4	2	2	NUM
bam-4803	289	5	+	+	NOUN
bam-4803	289	6	release	release	NOUN
bam-4803	289	7	channels	channel	NOUN
bam-4803	289	8	with	with	ADP
bam-4803	289	9	ryanodine	ryanodine	NOUN
bam-4803	289	10	in	in	ADP
bam-4803	289	11	junctional	junctional	ADJ
bam-4803	289	12	terminal	terminal	ADJ
bam-4803	289	13	cisternae	cisternae	NOUN
bam-4803	289	14	of	of	ADP
bam-4803	289	15	sarcoplasmic	sarcoplasmic	ADJ
bam-4803	289	16	reticulum	reticulum	NOUN
bam-4803	289	17	of	of	ADP
bam-4803	289	18	fast	fast	ADJ
bam-4803	289	19	skeletal	skeletal	ADJ
bam-4803	289	20	muscle	muscle	NOUN
bam-4803	289	21	.	.	PUNCT
bam-4803	290	1	proc	proc	PROPN
bam-4803	290	2	natl	natl	PROPN
bam-4803	290	3	acad	acad	PROPN
bam-4803	290	4	sci	sci	PROPN
bam-4803	290	5	u	u	PROPN
bam-4803	290	6	s	s	PROPN
bam-4803	290	7	a	a	DET
bam-4803	290	8	1985;82:7256	1985;82:7256	NUM
bam-4803	290	9	-	-	SYM
bam-4803	290	10	9	9	NUM
bam-4803	290	11	.	.	NOUN
bam-4803	290	12	30	30	NUM
bam-4803	290	13	.	.	PUNCT
bam-4803	291	1	needleman	needleman	PROPN
bam-4803	291	2	dh	dh	PROPN
bam-4803	291	3	,	,	PUNCT
bam-4803	291	4	hamilton	hamilton	PROPN
bam-4803	291	5	sl	sl	PROPN
bam-4803	291	6	.	.	PUNCT
bam-4803	292	1	factors	factor	NOUN
bam-4803	292	2	influencing	influence	VERB
bam-4803	292	3	[	[	X
bam-4803	292	4	3h	3h	NUM
bam-4803	292	5	]	]	PUNCT
bam-4803	292	6	ryanodine	ryanodine	NOUN
bam-4803	292	7	binding	bind	VERB
bam-4803	292	8	to	to	ADP
bam-4803	292	9	the	the	DET
bam-4803	292	10	skeletal	skeletal	ADJ
bam-4803	292	11	muscle	muscle	NOUN
bam-4803	292	12	ca	ca	NOUN
bam-4803	292	13	2	2	NUM
bam-4803	292	14	+	+	NOUN
bam-4803	292	15	release	release	NOUN
bam-4803	292	16	channel	channel	NOUN
bam-4803	292	17	.	.	PUNCT
bam-4803	293	1	anal	anal	ADJ
bam-4803	293	2	biochem	biochem	NOUN
bam-4803	293	3	1997;248:173	1997;248:173	NUM
bam-4803	293	4	-	-	SYM
bam-4803	293	5	9	9	NUM
bam-4803	293	6	.	.	NOUN
bam-4803	293	7	31	31	NUM
bam-4803	293	8	.	.	PUNCT
bam-4803	294	1	sutko	sutko	PROPN
bam-4803	294	2	jl	jl	PROPN
bam-4803	294	3	,	,	PUNCT
bam-4803	294	4	kenyon	kenyon	PROPN
bam-4803	294	5	jl	jl	PROPN
bam-4803	294	6	.	.	PUNCT
bam-4803	295	1	actions	action	NOUN
bam-4803	295	2	of	of	ADP
bam-4803	295	3	ryanodine	ryanodine	NOUN
bam-4803	296	1	[	[	X
bam-4803	296	2	letter	letter	NOUN
bam-4803	296	3	]	]	PUNCT
bam-4803	296	4	.	.	PUNCT
bam-4803	297	1	j	j	PROPN
bam-4803	297	2	gen	gen	PROPN
bam-4803	297	3	physiol	physiol	PROPN
bam-4803	297	4	1990;96:439	1990;96:439	PROPN
bam-4803	297	5	-	-	SYM
bam-4803	297	6	45	45	NUM
bam-4803	297	7	.	.	PUNCT
bam-4803	297	8	32	32	NUM
bam-4803	297	9	.	.	PUNCT
bam-4803	298	1	saito	saito	PROPN
bam-4803	298	2	a	a	PROPN
bam-4803	298	3	,	,	PUNCT
bam-4803	298	4	inui	inui	PROPN
bam-4803	298	5	m	m	PROPN
bam-4803	298	6	,	,	PUNCT
bam-4803	298	7	radermacher	radermacher	PROPN
bam-4803	298	8	m	m	PROPN
bam-4803	298	9	,	,	PUNCT
bam-4803	298	10	frank	frank	PROPN
bam-4803	298	11	j	j	PROPN
bam-4803	298	12	,	,	PUNCT
bam-4803	298	13	fleischer	fleischer	PROPN
bam-4803	298	14	s.	s.	PROPN
bam-4803	298	15	ultrastructure	ultrastructure	PROPN
bam-4803	298	16	of	of	ADP
bam-4803	298	17	the	the	DET
bam-4803	298	18	calcium	calcium	NOUN
bam-4803	298	19	release	release	NOUN
bam-4803	298	20	channel	channel	NOUN
bam-4803	298	21	of	of	ADP
bam-4803	298	22	sarcoplasmic	sarcoplasmic	ADJ
bam-4803	298	23	reticulum	reticulum	NOUN
bam-4803	298	24	.	.	PUNCT
bam-4803	299	1	j	j	PROPN
bam-4803	299	2	cell	cell	NOUN
bam-4803	299	3	biol	biol	PROPN
bam-4803	299	4	1988;107:211	1988;107:211	NUM
bam-4803	299	5	-	-	SYM
bam-4803	299	6	9	9	NUM
bam-4803	299	7	.	.	NOUN
bam-4803	299	8	33	33	NUM
bam-4803	299	9	.	.	PUNCT
bam-4803	300	1	wagenknecht	wagenknecht	PROPN
bam-4803	300	2	t	t	PROPN
bam-4803	300	3	,	,	PUNCT
bam-4803	300	4	grassucci	grassucci	NOUN
bam-4803	300	5	r	r	NOUN
bam-4803	300	6	,	,	PUNCT
bam-4803	300	7	frank	frank	PROPN
bam-4803	300	8	j	j	PROPN
bam-4803	300	9	,	,	PUNCT
bam-4803	300	10	et	et	PROPN
bam-4803	300	11	al	al	PROPN
bam-4803	300	12	.	.	PROPN
bam-4803	301	1	three	three	NUM
bam-4803	301	2	-	-	PUNCT
bam-4803	301	3	dimensional	dimensional	ADJ
bam-4803	301	4	architecture	architecture	NOUN
bam-4803	301	5	of	of	ADP
bam-4803	301	6	the	the	DET
bam-4803	301	7	calcium	calcium	NOUN
bam-4803	301	8	channel	channel	NOUN
bam-4803	301	9	/	/	SYM
bam-4803	301	10	foot	foot	NOUN
bam-4803	301	11	structure	structure	NOUN
bam-4803	301	12	of	of	ADP
bam-4803	301	13	sarcoplasmic	sarcoplasmic	ADJ
bam-4803	301	14	reticulum	reticulum	NOUN
bam-4803	301	15	.	.	PUNCT
bam-4803	302	1	nature	nature	NOUN
bam-4803	302	2	1989;338(6211):167	1989;338(6211):167	NUM
bam-4803	302	3	-	-	SYM
bam-4803	302	4	70	70	NUM
bam-4803	302	5	.	.	PUNCT
bam-4803	303	1	34	34	NUM
bam-4803	303	2	.	.	PUNCT
bam-4803	304	1	radermacher	radermacher	PROPN
bam-4803	304	2	m	m	PROPN
bam-4803	304	3	,	,	PUNCT
bam-4803	304	4	rao	rao	PROPN
bam-4803	304	5	v	v	NOUN
bam-4803	304	6	,	,	PUNCT
bam-4803	304	7	grassucci	grassucci	NOUN
bam-4803	304	8	r	r	NOUN
bam-4803	304	9	,	,	PUNCT
bam-4803	304	10	et	et	PROPN
bam-4803	304	11	al	al	PROPN
bam-4803	304	12	.	.	PROPN
bam-4803	304	13	cryoelectron	cryoelectron	PROPN
bam-4803	304	14	microscopy	microscopy	PROPN
bam-4803	304	15	and	and	CCONJ
bam-4803	304	16	three	three	NUM
bam-4803	304	17	-	-	PUNCT
bam-4803	304	18	dimensional	dimensional	ADJ
bam-4803	304	19	reconstruction	reconstruction	NOUN
bam-4803	304	20	of	of	ADP
bam-4803	304	21	the	the	DET
bam-4803	304	22	calcium	calcium	NOUN
bam-4803	304	23	release	release	NOUN
bam-4803	304	24	channel	channel	NOUN
bam-4803	304	25	/	/	SYM
bam-4803	304	26	ryanodine	ryanodine	NOUN
bam-4803	304	27	receptor	receptor	NOUN
bam-4803	304	28	from	from	ADP
bam-4803	304	29	skeletal	skeletal	ADJ
bam-4803	304	30	muscle	muscle	NOUN
bam-4803	304	31	.	.	PUNCT
bam-4803	305	1	j	j	PROPN
bam-4803	305	2	cell	cell	PROPN
bam-4803	305	3	biol	biol	PROPN
bam-4803	305	4	1994;127:411	1994;127:411	PROPN
bam-4803	305	5	-	-	SYM
bam-4803	305	6	23	23	NUM
bam-4803	305	7	.	.	PUNCT
bam-4803	305	8	35	35	NUM
bam-4803	305	9	.	.	PUNCT
bam-4803	306	1	wagenknecht	wagenknecht	PROPN
bam-4803	306	2	t	t	PROPN
bam-4803	306	3	,	,	PUNCT
bam-4803	306	4	radermacher	radermacher	ADJ
bam-4803	306	5	m.	m.	NOUN
bam-4803	306	6	threedimensional	threedimensional	ADJ
bam-4803	306	7	architecture	architecture	NOUN
bam-4803	306	8	of	of	ADP
bam-4803	306	9	the	the	DET
bam-4803	306	10	skeletal	skeletal	ADJ
bam-4803	306	11	muscle	muscle	NOUN
bam-4803	306	12	ryanodine	ryanodine	NOUN
bam-4803	306	13	receptor	receptor	NOUN
bam-4803	306	14	.	.	PUNCT
bam-4803	307	1	febs	febs	PROPN
bam-4803	307	2	lett	lett	PROPN
bam-4803	307	3	1995;369:43	1995;369:43	PROPN
bam-4803	307	4	-	-	SYM
bam-4803	307	5	6	6	NUM
bam-4803	307	6	.	.	NUM
bam-4803	307	7	36	36	NUM
bam-4803	307	8	.	.	PUNCT
bam-4803	307	9	serysheva	serysheva	PROPN
bam-4803	307	10	ii	ii	PROPN
bam-4803	307	11	,	,	PUNCT
bam-4803	307	12	orlova	orlova	PROPN
bam-4803	307	13	ev	ev	PROPN
bam-4803	307	14	,	,	PUNCT
bam-4803	307	15	chiu	chiu	PROPN
bam-4803	307	16	w	w	PROPN
bam-4803	307	17	,	,	PUNCT
bam-4803	307	18	et	et	PROPN
bam-4803	307	19	al	al	PROPN
bam-4803	307	20	.	.	PROPN
bam-4803	307	21	electron	electron	PROPN
bam-4803	307	22	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	307	23	and	and	CCONJ
bam-4803	307	24	angular	angular	ADJ
bam-4803	307	25	reconstitution	reconstitution	NOUN
bam-4803	307	26	used	use	VERB
bam-4803	307	27	to	to	PART
bam-4803	307	28	visualize	visualize	VERB
bam-4803	307	29	the	the	DET
bam-4803	307	30	skeletal	skeletal	ADJ
bam-4803	307	31	muscle	muscle	NOUN
bam-4803	307	32	calcium	calcium	NOUN
bam-4803	307	33	release	release	NOUN
bam-4803	307	34	channel	channel	NOUN
bam-4803	307	35	.	.	PUNCT
bam-4803	308	1	nat	nat	PROPN
bam-4803	308	2	struct	struct	NOUN
bam-4803	308	3	biol	biol	PROPN
bam-4803	308	4	1995;2:18	1995;2:18	PROPN
bam-4803	308	5	-	-	PUNCT
bam-4803	308	6	24	24	NUM
bam-4803	308	7	.	.	PUNCT
bam-4803	308	8	37	37	NUM
bam-4803	308	9	.	.	PUNCT
bam-4803	309	1	ludtke	ludtke	PROPN
bam-4803	309	2	sj	sj	PROPN
bam-4803	309	3	,	,	PUNCT
bam-4803	309	4	serysheva	serysheva	PROPN
bam-4803	309	5	,	,	PUNCT
bam-4803	309	6	ii	ii	PROPN
bam-4803	309	7	,	,	PUNCT
bam-4803	309	8	hamilton	hamilton	PROPN
bam-4803	309	9	sl	sl	PROPN
bam-4803	309	10	,	,	PUNCT
bam-4803	309	11	chiu	chiu	PROPN
bam-4803	309	12	w.	w.	PROPN
bam-4803	310	1	the	the	DET
bam-4803	310	2	pore	pore	ADJ
bam-4803	310	3	structure	structure	NOUN
bam-4803	310	4	of	of	ADP
bam-4803	310	5	the	the	DET
bam-4803	310	6	closed	closed	ADJ
bam-4803	310	7	ryr1	ryr1	NOUN
bam-4803	310	8	channel	channel	NOUN
bam-4803	310	9	.	.	PUNCT
bam-4803	311	1	structure	structure	NOUN
bam-4803	311	2	(	(	PUNCT
bam-4803	311	3	camb	camb	PROPN
bam-4803	311	4	)	)	PUNCT
bam-4803	311	5	2005;13:1203	2005;13:1203	NUM
bam-4803	311	6	-	-	SYM
bam-4803	311	7	11	11	NUM
bam-4803	311	8	.	.	PUNCT
bam-4803	312	1	38	38	NUM
bam-4803	312	2	.	.	PUNCT
bam-4803	312	3	serysheva	serysheva	PROPN
bam-4803	312	4	ii	ii	PROPN
bam-4803	312	5	,	,	PUNCT
bam-4803	312	6	hamilton	hamilton	PROPN
bam-4803	312	7	sl	sl	PROPN
bam-4803	312	8	,	,	PUNCT
bam-4803	312	9	chiu	chiu	PROPN
bam-4803	312	10	w	w	PROPN
bam-4803	312	11	,	,	PUNCT
bam-4803	312	12	ludtke	ludtke	PROPN
bam-4803	312	13	sj	sj	PROPN
bam-4803	312	14	.	.	PUNCT
bam-4803	312	15	structure	structure	NOUN
bam-4803	312	16	of	of	ADP
bam-4803	312	17	ca	ca	NOUN
bam-4803	312	18	2	2	NUM
bam-4803	312	19	+	+	NOUN
bam-4803	312	20	release	release	NOUN
bam-4803	312	21	channel	channel	NOUN
bam-4803	312	22	at	at	ADP
bam-4803	312	23	14	14	NUM
bam-4803	312	24	å	å	PROPN
bam-4803	312	25	resolution	resolution	NOUN
bam-4803	312	26	.	.	PUNCT
bam-4803	313	1	j	j	PROPN
bam-4803	313	2	mol	mol	ADP
bam-4803	313	3	biol	biol	PROPN
bam-4803	313	4	2005;345:427	2005;345:427	NUM
bam-4803	313	5	-	-	SYM
bam-4803	313	6	31	31	NUM
bam-4803	313	7	.	.	PUNCT
bam-4803	313	8	39	39	NUM
bam-4803	313	9	.	.	PUNCT
bam-4803	314	1	serysheva	serysheva	PROPN
bam-4803	314	2	ii	ii	PROPN
bam-4803	314	3	,	,	PUNCT
bam-4803	314	4	ludtke	ludtke	PROPN
bam-4803	314	5	sj	sj	PROPN
bam-4803	314	6	,	,	PUNCT
bam-4803	314	7	baker	baker	PROPN
bam-4803	314	8	ml	ml	PROPN
bam-4803	314	9	,	,	PUNCT
bam-4803	314	10	et	et	PROPN
bam-4803	314	11	al	al	PROPN
bam-4803	314	12	.	.	PUNCT
bam-4803	314	13	subnanometer	subnanometer	NOUN
bam-4803	314	14	-	-	PUNCT
bam-4803	314	15	resolution	resolution	NOUN
bam-4803	314	16	electron	electron	NOUN
bam-4803	314	17	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	314	18	-	-	PUNCT
bam-4803	314	19	based	base	VERB
bam-4803	314	20	domain	domain	NOUN
bam-4803	314	21	models	model	NOUN
bam-4803	314	22	for	for	ADP
bam-4803	314	23	the	the	DET
bam-4803	314	24	cytoplasmic	cytoplasmic	ADJ
bam-4803	314	25	region	region	NOUN
bam-4803	314	26	of	of	ADP
bam-4803	314	27	skeletal	skeletal	ADJ
bam-4803	314	28	muscle	muscle	NOUN
bam-4803	314	29	ryr	ryr	NOUN
bam-4803	314	30	channel	channel	PROPN
bam-4803	314	31	.	.	PUNCT
bam-4803	315	1	proc	proc	PROPN
bam-4803	315	2	natl	natl	PROPN
bam-4803	315	3	acad	acad	PROPN
bam-4803	315	4	sci	sci	PROPN
bam-4803	315	5	u	u	PROPN
bam-4803	315	6	s	s	PROPN
bam-4803	315	7	a	a	DET
bam-4803	315	8	2008;105:9610	2008;105:9610	NUM
bam-4803	315	9	-	-	SYM
bam-4803	315	10	5	5	NUM
bam-4803	315	11	.	.	NUM
bam-4803	315	12	40	40	NUM
bam-4803	315	13	.	.	PUNCT
bam-4803	316	1	samso	samso	PROPN
bam-4803	316	2	m	m	PROPN
bam-4803	316	3	,	,	PUNCT
bam-4803	316	4	wagenknecht	wagenknecht	PROPN
bam-4803	316	5	t	t	PROPN
bam-4803	316	6	,	,	PUNCT
bam-4803	316	7	allen	allen	PROPN
bam-4803	316	8	pd	pd	PROPN
bam-4803	316	9	.	.	PROPN
bam-4803	316	10	internal	internal	ADJ
bam-4803	316	11	structure	structure	NOUN
bam-4803	316	12	and	and	CCONJ
bam-4803	316	13	visualization	visualization	NOUN
bam-4803	316	14	of	of	ADP
bam-4803	316	15	transmembrane	transmembrane	ADJ
bam-4803	316	16	domains	domain	NOUN
bam-4803	316	17	of	of	ADP
bam-4803	316	18	the	the	DET
bam-4803	316	19	ryr1	ryr1	NOUN
bam-4803	316	20	calcium	calcium	NOUN
bam-4803	316	21	release	release	NOUN
bam-4803	316	22	channel	channel	NOUN
bam-4803	316	23	by	by	ADP
bam-4803	316	24	cryo	cryo	PROPN
bam-4803	316	25	-	-	PUNCT
bam-4803	316	26	em	em	PROPN
bam-4803	316	27	.	.	PUNCT
bam-4803	317	1	nat	nat	PROPN
bam-4803	317	2	struct	struct	NOUN
bam-4803	317	3	mol	mol	ADP
bam-4803	317	4	biol	biol	PROPN
bam-4803	317	5	2005;12:539	2005;12:539	PROPN
bam-4803	317	6	-	-	SYM
bam-4803	317	7	44	44	NUM
bam-4803	317	8	.	.	PUNCT
bam-4803	317	9	41	41	NUM
bam-4803	317	10	.	.	PUNCT
bam-4803	318	1	samso	samso	PROPN
bam-4803	318	2	m	m	PROPN
bam-4803	318	3	,	,	PUNCT
bam-4803	318	4	feng	feng	PROPN
bam-4803	318	5	w	w	PROPN
bam-4803	318	6	,	,	PUNCT
bam-4803	318	7	pessah	pessah	VERB
bam-4803	318	8	in	in	ADP
bam-4803	318	9	,	,	PUNCT
bam-4803	318	10	allen	allen	PROPN
bam-4803	318	11	pd	pd	PROPN
bam-4803	318	12	.	.	PROPN
bam-4803	318	13	coordinated	coordinate	VERB
bam-4803	318	14	movement	movement	NOUN
bam-4803	318	15	of	of	ADP
bam-4803	318	16	cytoplasmic	cytoplasmic	ADJ
bam-4803	318	17	and	and	CCONJ
bam-4803	318	18	transmembrane	transmembrane	ADJ
bam-4803	318	19	domains	domain	NOUN
bam-4803	318	20	of	of	ADP
bam-4803	318	21	ryr1	ryr1	NOUN
bam-4803	318	22	upon	upon	SCONJ
bam-4803	318	23	gating	gate	VERB
bam-4803	318	24	.	.	PUNCT
bam-4803	319	1	plos	plos	PROPN
bam-4803	319	2	biology	biology	NOUN
bam-4803	319	3	2009;7	2009;7	NOUN
bam-4803	319	4	:	:	PUNCT
bam-4803	319	5	e85	e85	NOUN
bam-4803	319	6	.	.	PUNCT
bam-4803	320	1	42	42	NUM
bam-4803	320	2	.	.	PUNCT
bam-4803	321	1	yin	yin	PROPN
bam-4803	321	2	cc	cc	PROPN
bam-4803	321	3	,	,	PUNCT
bam-4803	321	4	han	han	PROPN
bam-4803	321	5	h	h	PROPN
bam-4803	321	6	,	,	PUNCT
bam-4803	321	7	wei	wei	PROPN
bam-4803	321	8	r	r	PROPN
bam-4803	321	9	,	,	PUNCT
bam-4803	321	10	lai	lai	PROPN
bam-4803	321	11	fa	fa	PROPN
bam-4803	321	12	.	.	PUNCT
bam-4803	321	13	twodimensional	twodimensional	ADJ
bam-4803	321	14	crystallization	crystallization	NOUN
bam-4803	321	15	of	of	ADP
bam-4803	321	16	the	the	DET
bam-4803	321	17	ryanodine	ryanodine	NOUN
bam-4803	321	18	receptor	receptor	NOUN
bam-4803	321	19	ca	ca	NOUN
bam-4803	321	20	2	2	NUM
bam-4803	321	21	+	+	NOUN
bam-4803	321	22	release	release	NOUN
bam-4803	321	23	channel	channel	NOUN
bam-4803	321	24	on	on	ADP
bam-4803	321	25	lipid	lipid	ADJ
bam-4803	321	26	membranes	membrane	NOUN
bam-4803	321	27	.	.	PUNCT
bam-4803	322	1	j	j	PROPN
bam-4803	322	2	struct	struct	VERB
bam-4803	322	3	biol	biol	PROPN
bam-4803	322	4	2005;149:219	2005;149:219	PROPN
bam-4803	322	5	-	-	SYM
bam-4803	322	6	24	24	NUM
bam-4803	322	7	.	.	PUNCT
bam-4803	323	1	43	43	NUM
bam-4803	323	2	.	.	PUNCT
bam-4803	324	1	sharma	sharma	PROPN
bam-4803	324	2	mr	mr	PROPN
bam-4803	324	3	,	,	PUNCT
bam-4803	324	4	jeyakumar	jeyakumar	PROPN
bam-4803	324	5	lh	lh	PROPN
bam-4803	324	6	,	,	PUNCT
bam-4803	324	7	fleischer	fleischer	PROPN
bam-4803	324	8	s	s	PART
bam-4803	324	9	,	,	PUNCT
bam-4803	324	10	wagenknecht	wagenknecht	PROPN
bam-4803	324	11	t.	t.	PROPN
bam-4803	324	12	three	three	NUM
bam-4803	324	13	-	-	PUNCT
bam-4803	324	14	dimensional	dimensional	ADJ
bam-4803	324	15	structure	structure	NOUN
bam-4803	324	16	of	of	ADP
bam-4803	324	17	ryanodine	ryanodine	ADJ
bam-4803	324	18	receptor	receptor	NOUN
bam-4803	324	19	isoform	isoform	NOUN
bam-4803	324	20	three	three	NUM
bam-4803	324	21	in	in	ADP
bam-4803	324	22	two	two	NUM
bam-4803	324	23	conformational	conformational	ADJ
bam-4803	324	24	states	state	NOUN
bam-4803	324	25	as	as	SCONJ
bam-4803	324	26	visualized	visualize	VERB
bam-4803	324	27	by	by	ADP
bam-4803	324	28	cryoelectron	cryoelectron	NOUN
bam-4803	324	29	microscopy	microscopy	NOUN
bam-4803	324	30	.	.	PUNCT
bam-4803	325	1	j	j	PROPN
bam-4803	325	2	biol	biol	PROPN
bam-4803	325	3	chem	chem	NOUN
bam-4803	325	4	2000;275:9485	2000;275:9485	NUM
bam-4803	325	5	-	-	SYM
bam-4803	325	6	91	91	NUM
bam-4803	325	7	.	.	PUNCT
bam-4803	325	8	44	44	NUM
bam-4803	325	9	.	.	PUNCT
bam-4803	326	1	liu	liu	PROPN
bam-4803	326	2	z	z	PROPN
bam-4803	326	3	,	,	PUNCT
bam-4803	326	4	zhang	zhang	PROPN
bam-4803	326	5	j	j	PROPN
bam-4803	326	6	,	,	PUNCT
bam-4803	326	7	sharma	sharma	PROPN
bam-4803	326	8	mr	mr	PROPN
bam-4803	326	9	,	,	PUNCT
bam-4803	326	10	et	et	PROPN
bam-4803	326	11	al	al	PROPN
bam-4803	326	12	.	.	PROPN
bam-4803	326	13	threedimensional	threedimensional	ADJ
bam-4803	326	14	reconstruction	reconstruction	NOUN
bam-4803	326	15	of	of	ADP
bam-4803	326	16	the	the	DET
bam-4803	326	17	recombinant	recombinant	ADJ
bam-4803	326	18	type	type	NOUN
bam-4803	326	19	3	3	NUM
bam-4803	326	20	ryanodine	ryanodine	NOUN
bam-4803	326	21	receptor	receptor	NOUN
bam-4803	326	22	and	and	CCONJ
bam-4803	326	23	localization	localization	NOUN
bam-4803	326	24	of	of	ADP
bam-4803	326	25	its	its	PRON
bam-4803	326	26	amino	amino	NOUN
bam-4803	326	27	terminus	terminus	NOUN
bam-4803	326	28	.	.	PUNCT
bam-4803	327	1	proc	proc	PROPN
bam-4803	327	2	natl	natl	PROPN
bam-4803	327	3	acad	acad	PROPN
bam-4803	327	4	sci	sci	PROPN
bam-4803	327	5	u	u	PROPN
bam-4803	327	6	s	s	PROPN
bam-4803	327	7	a	a	DET
bam-4803	327	8	2001;98:6104	2001;98:6104	NUM
bam-4803	327	9	-	-	SYM
bam-4803	327	10	9	9	NUM
bam-4803	327	11	.	.	NOUN
bam-4803	327	12	45	45	NUM
bam-4803	327	13	.	.	PUNCT
bam-4803	328	1	sharma	sharma	PROPN
bam-4803	328	2	mr	mr	PROPN
bam-4803	328	3	,	,	PUNCT
bam-4803	328	4	penczek	penczek	NOUN
bam-4803	328	5	p	p	NOUN
bam-4803	328	6	,	,	PUNCT
bam-4803	328	7	grassucci	grassucci	NOUN
bam-4803	328	8	r	r	NOUN
bam-4803	328	9	,	,	PUNCT
bam-4803	328	10	et	et	PROPN
bam-4803	328	11	al	al	PROPN
bam-4803	328	12	.	.	PROPN
bam-4803	328	13	cryoelectron	cryoelectron	PROPN
bam-4803	328	14	microscopy	microscopy	NOUN
bam-4803	328	15	and	and	CCONJ
bam-4803	328	16	image	image	NOUN
bam-4803	328	17	analysis	analysis	NOUN
bam-4803	328	18	of	of	ADP
bam-4803	328	19	the	the	DET
bam-4803	328	20	cardiac	cardiac	ADJ
bam-4803	328	21	ryanodine	ryanodine	NOUN
bam-4803	328	22	receptor	receptor	NOUN
bam-4803	328	23	.	.	PUNCT
bam-4803	329	1	j	j	PROPN
bam-4803	329	2	biol	biol	PROPN
bam-4803	329	3	chem	chem	NOUN
bam-4803	329	4	1998;273:18429	1998;273:18429	NUM
bam-4803	329	5	-	-	SYM
bam-4803	329	6	34	34	NUM
bam-4803	329	7	.	.	PUNCT
bam-4803	329	8	46	46	NUM
bam-4803	329	9	.	.	PUNCT
bam-4803	330	1	liu	liu	PROPN
bam-4803	330	2	z	z	PROPN
bam-4803	330	3	,	,	PUNCT
bam-4803	330	4	zhang	zhang	PROPN
bam-4803	330	5	j	j	PROPN
bam-4803	330	6	,	,	PUNCT
bam-4803	330	7	li	li	PROPN
bam-4803	330	8	p	p	PROPN
bam-4803	330	9	,	,	PUNCT
bam-4803	330	10	et	et	PROPN
bam-4803	330	11	al	al	PROPN
bam-4803	330	12	.	.	PROPN
bam-4803	330	13	three	three	NUM
bam-4803	330	14	-	-	PUNCT
bam-4803	330	15	dimensional	dimensional	ADJ
bam-4803	330	16	reconstruction	reconstruction	NOUN
bam-4803	330	17	of	of	ADP
bam-4803	330	18	the	the	DET
bam-4803	330	19	recombinant	recombinant	ADJ
bam-4803	330	20	type	type	NOUN
bam-4803	330	21	2	2	NUM
bam-4803	330	22	ryanodine	ryanodine	NOUN
bam-4803	330	23	receptor	receptor	NOUN
bam-4803	330	24	and	and	CCONJ
bam-4803	330	25	localization	localization	NOUN
bam-4803	330	26	of	of	ADP
bam-4803	330	27	its	its	PRON
bam-4803	330	28	divergent	divergent	ADJ
bam-4803	330	29	region	region	NOUN
bam-4803	330	30	1	1	NUM
bam-4803	330	31	.	.	PUNCT
bam-4803	331	1	j	j	PROPN
bam-4803	331	2	biol	biol	PROPN
bam-4803	331	3	chem	chem	NOUN
bam-4803	331	4	2002;277:467129	2002;277:467129	NUM
bam-4803	331	5	.	.	PUNCT
bam-4803	332	1	47	47	NUM
bam-4803	332	2	.	.	PUNCT
bam-4803	333	1	zhang	zhang	PROPN
bam-4803	333	2	j	j	PROPN
bam-4803	333	3	,	,	PUNCT
bam-4803	333	4	liu	liu	PROPN
bam-4803	333	5	z	z	PROPN
bam-4803	333	6	,	,	PUNCT
bam-4803	333	7	masumiya	masumiya	PROPN
bam-4803	333	8	h	h	NOUN
bam-4803	333	9	,	,	PUNCT
bam-4803	333	10	et	et	PROPN
bam-4803	333	11	al	al	PROPN
bam-4803	333	12	.	.	PROPN
bam-4803	333	13	threedimensional	threedimensional	ADJ
bam-4803	333	14	localization	localization	NOUN
bam-4803	333	15	of	of	ADP
bam-4803	333	16	divergent	divergent	ADJ
bam-4803	333	17	region	region	NOUN
bam-4803	333	18	3	3	NUM
bam-4803	333	19	of	of	ADP
bam-4803	333	20	the	the	DET
bam-4803	333	21	ryanodine	ryanodine	NOUN
bam-4803	333	22	receptor	receptor	NOUN
bam-4803	333	23	to	to	ADP
bam-4803	333	24	the	the	DET
bam-4803	333	25	clamp	clamp	NOUN
bam-4803	333	26	-	-	PUNCT
bam-4803	333	27	shaped	shape	VERB
bam-4803	333	28	structures	structure	NOUN
bam-4803	333	29	adjacent	adjacent	ADJ
bam-4803	333	30	to	to	ADP
bam-4803	333	31	the	the	DET
bam-4803	333	32	fkbp	fkbp	ADJ
bam-4803	333	33	binding	bind	VERB
bam-4803	333	34	sites	site	NOUN
bam-4803	333	35	.	.	PUNCT
bam-4803	334	1	j	j	PROPN
bam-4803	334	2	biol	biol	PROPN
bam-4803	334	3	chem	chem	NOUN
bam-4803	334	4	2003;278:14211	2003;278:14211	NUM
bam-4803	334	5	-	-	SYM
bam-4803	334	6	8	8	NUM
bam-4803	334	7	.	.	PUNCT
bam-4803	334	8	48	48	NUM
bam-4803	334	9	.	.	PUNCT
bam-4803	335	1	liu	liu	PROPN
bam-4803	335	2	z	z	PROPN
bam-4803	335	3	,	,	PUNCT
bam-4803	335	4	wang	wang	PROPN
bam-4803	335	5	r	r	PROPN
bam-4803	335	6	,	,	PUNCT
bam-4803	335	7	zhang	zhang	PROPN
bam-4803	335	8	j	j	PROPN
bam-4803	335	9	,	,	PUNCT
bam-4803	335	10	et	et	PROPN
bam-4803	335	11	al	al	PROPN
bam-4803	335	12	.	.	PUNCT
bam-4803	336	1	localization	localization	NOUN
bam-4803	336	2	of	of	ADP
bam-4803	336	3	a	a	DET
bam-4803	336	4	disease	disease	NOUN
bam-4803	336	5	-	-	PUNCT
bam-4803	336	6	associated	associate	VERB
bam-4803	336	7	mutation	mutation	NOUN
bam-4803	336	8	site	site	NOUN
bam-4803	336	9	in	in	ADP
bam-4803	336	10	the	the	DET
bam-4803	336	11	threedimensional	threedimensional	ADJ
bam-4803	336	12	structure	structure	NOUN
bam-4803	336	13	of	of	ADP
bam-4803	336	14	the	the	DET
bam-4803	336	15	cardiac	cardiac	ADJ
bam-4803	336	16	muscle	muscle	NOUN
bam-4803	336	17	ryanodine	ryanodine	NOUN
bam-4803	336	18	receptor	receptor	NOUN
bam-4803	336	19	.	.	PUNCT
bam-4803	337	1	j	j	PROPN
bam-4803	337	2	biol	biol	PROPN
bam-4803	337	3	chem	chem	NOUN
bam-4803	337	4	2005;280:37941	2005;280:37941	NUM
bam-4803	337	5	-	-	SYM
bam-4803	337	6	7	7	NUM
bam-4803	337	7	.	.	NUM
bam-4803	337	8	49	49	NUM
bam-4803	337	9	.	.	PUNCT
bam-4803	338	1	wang	wang	PROPN
bam-4803	338	2	r	r	PROPN
bam-4803	338	3	,	,	PUNCT
bam-4803	338	4	chen	chen	PROPN
bam-4803	338	5	w	w	PROPN
bam-4803	338	6	,	,	PUNCT
bam-4803	338	7	cai	cai	PROPN
bam-4803	338	8	s	s	PROPN
bam-4803	338	9	,	,	PUNCT
bam-4803	338	10	et	et	PROPN
bam-4803	338	11	al	al	PROPN
bam-4803	338	12	.	.	PUNCT
bam-4803	338	13	localization	localization	NOUN
bam-4803	338	14	of	of	ADP
bam-4803	338	15	an	an	DET
bam-4803	338	16	nh(2)-terminal	nh(2)-terminal	ADJ
bam-4803	338	17	disease	disease	NOUN
bam-4803	338	18	-	-	PUNCT
bam-4803	338	19	causing	cause	VERB
bam-4803	338	20	mutation	mutation	NOUN
bam-4803	338	21	hot	hot	ADJ
bam-4803	338	22	spot	spot	NOUN
bam-4803	338	23	to	to	ADP
bam-4803	338	24	the	the	DET
bam-4803	338	25	"	"	PUNCT
bam-4803	338	26	clamp	clamp	NOUN
bam-4803	338	27	"	"	PUNCT
bam-4803	338	28	region	region	NOUN
bam-4803	338	29	in	in	ADP
bam-4803	338	30	the	the	DET
bam-4803	338	31	three	three	NUM
bam-4803	338	32	-	-	PUNCT
bam-4803	338	33	dimensional	dimensional	ADJ
bam-4803	338	34	structure	structure	NOUN
bam-4803	338	35	of	of	ADP
bam-4803	338	36	the	the	DET
bam-4803	338	37	cardiac	cardiac	ADJ
bam-4803	338	38	ryanodine	ryanodine	NOUN
bam-4803	338	39	receptor	receptor	NOUN
bam-4803	338	40	.	.	PUNCT
bam-4803	339	1	j	j	PROPN
bam-4803	339	2	biol	biol	PROPN
bam-4803	339	3	chem	chem	NOUN
bam-4803	339	4	2007;282:17785	2007;282:17785	NUM
bam-4803	339	5	-	-	SYM
bam-4803	339	6	93	93	NUM
bam-4803	339	7	.	.	PUNCT
bam-4803	340	1	50	50	NUM
bam-4803	340	2	.	.	PUNCT
bam-4803	341	1	liu	liu	PROPN
bam-4803	341	2	z	z	PROPN
bam-4803	341	3	,	,	PUNCT
bam-4803	341	4	zhang	zhang	PROPN
bam-4803	341	5	j	j	PROPN
bam-4803	341	6	,	,	PUNCT
bam-4803	341	7	wang	wang	PROPN
bam-4803	341	8	r	r	PROPN
bam-4803	341	9	,	,	PUNCT
bam-4803	341	10	et	et	PROPN
bam-4803	341	11	al	al	PROPN
bam-4803	341	12	.	.	PROPN
bam-4803	341	13	location	location	NOUN
bam-4803	341	14	of	of	ADP
bam-4803	341	15	divergent	divergent	ADJ
bam-4803	341	16	region	region	NOUN
bam-4803	341	17	2	2	NUM
bam-4803	341	18	on	on	ADP
bam-4803	341	19	the	the	DET
bam-4803	341	20	three	three	NUM
bam-4803	341	21	-	-	PUNCT
bam-4803	341	22	dimensional	dimensional	ADJ
bam-4803	341	23	structure	structure	NOUN
bam-4803	341	24	of	of	ADP
bam-4803	341	25	cardiac	cardiac	ADJ
bam-4803	341	26	muscle	muscle	NOUN
bam-4803	341	27	ryanodine	ryanodine	NOUN
bam-4803	341	28	receptor	receptor	NOUN
bam-4803	341	29	/	/	SYM
bam-4803	341	30	calcium	calcium	NOUN
bam-4803	341	31	release	release	NOUN
bam-4803	341	32	channel	channel	NOUN
bam-4803	341	33	.	.	PUNCT
bam-4803	342	1	j	j	PROPN
bam-4803	342	2	mol	mol	ADP
bam-4803	342	3	biol	biol	PROPN
bam-4803	342	4	2004;338:533	2004;338:533	NUM
bam-4803	342	5	-	-	SYM
bam-4803	342	6	45	45	NUM
bam-4803	342	7	.	.	PUNCT
bam-4803	342	8	51	51	NUM
bam-4803	342	9	.	.	NOUN
bam-4803	343	1	wagenknecht	wagenknecht	PROPN
bam-4803	343	2	t	t	PROPN
bam-4803	343	3	,	,	PUNCT
bam-4803	343	4	grassucci	grassucci	NOUN
bam-4803	343	5	r	r	NOUN
bam-4803	343	6	,	,	PUNCT
bam-4803	343	7	berkowitz	berkowitz	PROPN
bam-4803	343	8	j	j	PROPN
bam-4803	343	9	,	,	PUNCT
bam-4803	343	10	et	et	PROPN
bam-4803	343	11	al	al	PROPN
bam-4803	343	12	.	.	PROPN
bam-4803	343	13	cryoelectron	cryoelectron	PROPN
bam-4803	343	14	microscopy	microscopy	PROPN
bam-4803	343	15	resolves	resolve	VERB
bam-4803	343	16	fk506	fk506	NOUN
bam-4803	343	17	-	-	PUNCT
bam-4803	343	18	binding	bind	VERB
bam-4803	343	19	protein	protein	NOUN
bam-4803	343	20	sites	site	NOUN
bam-4803	343	21	on	on	ADP
bam-4803	343	22	the	the	DET
bam-4803	343	23	skeletal	skeletal	ADJ
bam-4803	343	24	muscle	muscle	NOUN
bam-4803	343	25	ryanodine	ryanodine	NOUN
bam-4803	343	26	receptor	receptor	NOUN
bam-4803	343	27	.	.	PUNCT
bam-4803	344	1	biophys	biophy	NOUN
bam-4803	344	2	j	j	PROPN
bam-4803	344	3	1996;70:1709	1996;70:1709	NUM
bam-4803	344	4	-	-	SYM
bam-4803	344	5	15	15	NUM
bam-4803	344	6	.	.	PUNCT
bam-4803	344	7	52	52	NUM
bam-4803	344	8	.	.	PUNCT
bam-4803	345	1	wagenknecht	wagenknecht	PROPN
bam-4803	345	2	t	t	PROPN
bam-4803	345	3	,	,	PUNCT
bam-4803	345	4	berkowitz	berkowitz	PROPN
bam-4803	345	5	j	j	PROPN
bam-4803	345	6	,	,	PUNCT
bam-4803	345	7	grassucci	grassucci	VERB
bam-4803	345	8	r	r	NOUN
bam-4803	345	9	,	,	PUNCT
bam-4803	345	10	et	et	PROPN
bam-4803	345	11	al	al	PROPN
bam-4803	345	12	.	.	PUNCT
bam-4803	346	1	localization	localization	NOUN
bam-4803	346	2	of	of	ADP
bam-4803	346	3	calmodulin	calmodulin	NOUN
bam-4803	346	4	binding	bind	VERB
bam-4803	346	5	sites	site	NOUN
bam-4803	346	6	on	on	ADP
bam-4803	346	7	the	the	DET
bam-4803	346	8	ryanodine	ryanodine	NOUN
bam-4803	346	9	receptor	receptor	NOUN
bam-4803	346	10	from	from	ADP
bam-4803	346	11	skeletal	skeletal	ADJ
bam-4803	346	12	muscle	muscle	NOUN
bam-4803	346	13	by	by	ADP
bam-4803	346	14	electron	electron	NOUN
bam-4803	346	15	microscopy	microscopy	NOUN
bam-4803	346	16	.	.	PUNCT
bam-4803	347	1	biophys	biophy	NOUN
bam-4803	347	2	j	j	PROPN
bam-4803	347	3	1994;67:2286	1994;67:2286	NUM
bam-4803	347	4	-	-	SYM
bam-4803	347	5	95	95	NUM
bam-4803	347	6	.	.	PUNCT
bam-4803	348	1	single	single	ADJ
bam-4803	348	2	-	-	PUNCT
bam-4803	348	3	particle	particle	NOUN
bam-4803	348	4	cryo	cryo	NOUN
bam-4803	348	5	-	-	PUNCT
bam-4803	348	6	em	em	PRON
bam-4803	348	7	of	of	ADP
bam-4803	348	8	the	the	DET
bam-4803	348	9	ryanodine	ryanodine	PROPN
bam-4803	348	10	receptor	receptor	NOUN
bam-4803	348	11	channel	channel	PROPN
bam-4803	348	12	eur	eur	PROPN
bam-4803	348	13	j	j	PROPN
bam-4803	348	14	transl	transl	PROPN
bam-4803	348	15	myol	myol	PROPN
bam-4803	348	16	basic	basic	ADJ
bam-4803	348	17	appl	appl	NOUN
bam-4803	348	18	myol	myol	NOUN
bam-4803	348	19	2015	2015	NUM
bam-4803	348	20	;	;	PUNCT
bam-4803	348	21	25	25	NUM
bam-4803	348	22	(	(	PUNCT
bam-4803	348	23	1	1	NUM
bam-4803	348	24	):	):	PUNCT
bam-4803	348	25	35	35	NUM
bam-4803	348	26	-	-	SYM
bam-4803	348	27	48	48	NUM
bam-4803	348	28	47	47	NUM
bam-4803	348	29	53	53	NUM
bam-4803	348	30	.	.	PUNCT
bam-4803	349	1	samso	samso	PROPN
bam-4803	349	2	m	m	PROPN
bam-4803	349	3	,	,	PUNCT
bam-4803	349	4	trujilo	trujilo	ADJ
bam-4803	349	5	r	r	NOUN
bam-4803	349	6	,	,	PUNCT
bam-4803	349	7	gurrola	gurrola	NOUN
bam-4803	349	8	gb	gb	PROPN
bam-4803	349	9	,	,	PUNCT
bam-4803	349	10	et	et	PROPN
bam-4803	349	11	al	al	PROPN
bam-4803	349	12	.	.	PROPN
bam-4803	349	13	threedimensional	threedimensional	ADJ
bam-4803	349	14	location	location	NOUN
bam-4803	349	15	of	of	ADP
bam-4803	349	16	the	the	DET
bam-4803	349	17	imperatoxin	imperatoxin	PROPN
bam-4803	349	18	a	a	DET
bam-4803	349	19	binding	bind	VERB
bam-4803	349	20	site	site	NOUN
bam-4803	349	21	on	on	ADP
bam-4803	349	22	the	the	DET
bam-4803	349	23	ryanodine	ryanodine	NOUN
bam-4803	349	24	receptor	receptor	NOUN
bam-4803	349	25	.	.	PUNCT
bam-4803	350	1	j	j	PROPN
bam-4803	350	2	cell	cell	NOUN
bam-4803	350	3	biol	biol	PROPN
bam-4803	350	4	1999;146:493	1999;146:493	NUM
bam-4803	350	5	-	-	SYM
bam-4803	350	6	99	99	NUM
bam-4803	350	7	.	.	PUNCT
bam-4803	350	8	54	54	NUM
bam-4803	350	9	.	.	PUNCT
bam-4803	351	1	orlova	orlova	PROPN
bam-4803	351	2	ev	ev	PROPN
bam-4803	351	3	,	,	PUNCT
bam-4803	351	4	serysheva	serysheva	PROPN
bam-4803	351	5	,	,	PUNCT
bam-4803	351	6	ii	ii	PROPN
bam-4803	351	7	,	,	PUNCT
bam-4803	351	8	van	van	PROPN
bam-4803	351	9	heel	heel	PROPN
bam-4803	351	10	m	m	PROPN
bam-4803	351	11	,	,	PUNCT
bam-4803	351	12	et	et	PROPN
bam-4803	351	13	al	al	PROPN
bam-4803	351	14	..	..	PROPN
bam-4803	351	15	two	two	NUM
bam-4803	351	16	structural	structural	ADJ
bam-4803	351	17	configurations	configuration	NOUN
bam-4803	351	18	of	of	ADP
bam-4803	351	19	the	the	DET
bam-4803	351	20	skeletal	skeletal	ADJ
bam-4803	351	21	muscle	muscle	NOUN
bam-4803	351	22	calcium	calcium	NOUN
bam-4803	351	23	release	release	NOUN
bam-4803	351	24	channel	channel	NOUN
bam-4803	351	25	.	.	PUNCT
bam-4803	352	1	nat	nat	PROPN
bam-4803	352	2	struct	struct	NOUN
bam-4803	352	3	biol	biol	PROPN
bam-4803	352	4	1996;3:547	1996;3:547	PROPN
bam-4803	352	5	-	-	SYM
bam-4803	352	6	52	52	NUM
bam-4803	352	7	.	.	PUNCT
bam-4803	353	1	55	55	NUM
bam-4803	353	2	.	.	PUNCT
bam-4803	353	3	serysheva	serysheva	PROPN
bam-4803	353	4	ii	ii	PROPN
bam-4803	353	5	,	,	PUNCT
bam-4803	353	6	schatz	schatz	PROPN
bam-4803	353	7	m	m	PROPN
bam-4803	353	8	,	,	PUNCT
bam-4803	353	9	van	van	PROPN
bam-4803	353	10	heel	heel	PROPN
bam-4803	353	11	m	m	PROPN
bam-4803	353	12	,	,	PUNCT
bam-4803	353	13	et	et	PROPN
bam-4803	353	14	al	al	PROPN
bam-4803	353	15	.	.	PUNCT
bam-4803	353	16	structure	structure	NOUN
bam-4803	353	17	of	of	ADP
bam-4803	353	18	the	the	DET
bam-4803	353	19	skeletal	skeletal	ADJ
bam-4803	353	20	muscle	muscle	NOUN
bam-4803	353	21	calcium	calcium	NOUN
bam-4803	353	22	release	release	NOUN
bam-4803	353	23	channel	channel	NOUN
bam-4803	353	24	activated	activate	VERB
bam-4803	353	25	with	with	ADP
bam-4803	353	26	ca	ca	NOUN
bam-4803	353	27	2	2	NUM
bam-4803	353	28	+	+	NUM
bam-4803	353	29	and	and	CCONJ
bam-4803	353	30	amp	amp	PROPN
bam-4803	353	31	-	-	PUNCT
bam-4803	353	32	pcp	pcp	NOUN
bam-4803	353	33	.	.	PUNCT
bam-4803	354	1	biophys	biophys	PROPN
bam-4803	354	2	j	j	PROPN
bam-4803	354	3	1999;77:1936	1999;77:1936	NUM
bam-4803	354	4	44	44	NUM
bam-4803	354	5	.	.	PUNCT
bam-4803	355	1	56	56	NUM
bam-4803	355	2	.	.	PUNCT
bam-4803	356	1	scheres	schere	NOUN
bam-4803	356	2	sh	sh	PROPN
bam-4803	356	3	,	,	PUNCT
bam-4803	356	4	chen	chen	PROPN
bam-4803	356	5	s.	s.	PROPN
bam-4803	356	6	prevention	prevention	PROPN
bam-4803	356	7	of	of	ADP
bam-4803	356	8	overfitting	overfitte	VERB
bam-4803	356	9	in	in	ADP
bam-4803	356	10	cryo	cryo	NOUN
bam-4803	356	11	-	-	PUNCT
bam-4803	356	12	em	em	PROPN
bam-4803	356	13	structure	structure	NOUN
bam-4803	356	14	determination	determination	NOUN
bam-4803	356	15	.	.	PUNCT
bam-4803	357	1	nat	nat	PROPN
bam-4803	357	2	methods	method	NOUN
bam-4803	357	3	2012;9(9):853	2012;9(9):853	NUM
bam-4803	357	4	-	-	SYM
bam-4803	357	5	4	4	NUM
bam-4803	357	6	.	.	NOUN
bam-4803	357	7	57	57	NUM
bam-4803	357	8	.	.	PUNCT
bam-4803	358	1	henderson	henderson	PROPN
bam-4803	358	2	r	r	PROPN
bam-4803	358	3	,	,	PUNCT
bam-4803	358	4	sali	sali	PROPN
bam-4803	358	5	a	a	X
bam-4803	358	6	,	,	PUNCT
bam-4803	358	7	baker	baker	PROPN
bam-4803	358	8	ml	ml	PROPN
bam-4803	358	9	,	,	PUNCT
bam-4803	359	1	et	et	PROPN
bam-4803	359	2	al	al	PROPN
bam-4803	359	3	.	.	PROPN
bam-4803	359	4	outcome	outcome	NOUN
bam-4803	359	5	of	of	ADP
bam-4803	359	6	the	the	DET
bam-4803	359	7	first	first	ADJ
bam-4803	359	8	electron	electron	NOUN
bam-4803	359	9	microscopy	microscopy	NOUN
bam-4803	359	10	validation	validation	NOUN
bam-4803	359	11	task	task	PROPN
bam-4803	359	12	force	force	NOUN
bam-4803	359	13	meeting	meeting	NOUN
bam-4803	359	14	.	.	PUNCT
bam-4803	360	1	structure	structure	NOUN
bam-4803	360	2	2012;20:205	2012;20:205	PROPN
bam-4803	360	3	-	-	SYM
bam-4803	360	4	14	14	NUM
bam-4803	360	5	.	.	PUNCT
bam-4803	361	1	58	58	NUM
bam-4803	361	2	.	.	PUNCT
bam-4803	362	1	baker	baker	PROPN
bam-4803	362	2	ml	ml	PROPN
bam-4803	362	3	,	,	PUNCT
bam-4803	362	4	baker	baker	PROPN
bam-4803	362	5	mr	mr	PROPN
bam-4803	362	6	,	,	PUNCT
bam-4803	362	7	hryc	hryc	PROPN
bam-4803	362	8	cf	cf	NOUN
bam-4803	362	9	,	,	PUNCT
bam-4803	362	10	dimaio	dimaio	PROPN
bam-4803	362	11	f.	f.	PROPN
bam-4803	362	12	analyses	analysis	NOUN
bam-4803	362	13	of	of	ADP
bam-4803	362	14	subnanometer	subnanometer	ADJ
bam-4803	362	15	resolution	resolution	NOUN
bam-4803	362	16	cryo	cryo	NOUN
bam-4803	362	17	-	-	PUNCT
bam-4803	362	18	em	em	PROPN
bam-4803	362	19	density	density	NOUN
bam-4803	362	20	maps	map	NOUN
bam-4803	362	21	.	.	PUNCT
bam-4803	363	1	meth	meth	NOUN
bam-4803	363	2	enzymol	enzymol	PROPN
bam-4803	363	3	2010;483:1	2010;483:1	PROPN
bam-4803	363	4	-	-	SYM
bam-4803	363	5	29	29	NUM
bam-4803	363	6	.	.	PUNCT
bam-4803	363	7	59	59	NUM
bam-4803	363	8	.	.	PUNCT
bam-4803	364	1	tung	tung	PROPN
bam-4803	364	2	cc	cc	PROPN
bam-4803	364	3	,	,	PUNCT
bam-4803	364	4	lobo	lobo	PROPN
bam-4803	364	5	pa	pa	PROPN
bam-4803	364	6	,	,	PUNCT
bam-4803	364	7	kimlicka	kimlicka	PROPN
bam-4803	364	8	l	l	PROPN
bam-4803	364	9	,	,	PUNCT
bam-4803	364	10	van	van	PROPN
bam-4803	364	11	petegem	petegem	PROPN
bam-4803	364	12	f.	f.	PROPN
bam-4803	365	1	the	the	DET
bam-4803	365	2	amino	amino	NOUN
bam-4803	365	3	-	-	PUNCT
bam-4803	365	4	terminal	terminal	ADJ
bam-4803	365	5	disease	disease	NOUN
bam-4803	365	6	hotspot	hotspot	NOUN
bam-4803	365	7	of	of	ADP
bam-4803	365	8	ryanodine	ryanodine	NOUN
bam-4803	365	9	receptors	receptor	NOUN
bam-4803	365	10	forms	form	VERB
bam-4803	365	11	a	a	DET
bam-4803	365	12	cytoplasmic	cytoplasmic	ADJ
bam-4803	365	13	vestibule	vestibule	NOUN
bam-4803	365	14	.	.	PUNCT
bam-4803	366	1	nature	nature	NOUN
bam-4803	366	2	2010;468(7323):585	2010;468(7323):585	NUM
bam-4803	366	3	-	-	SYM
bam-4803	366	4	8	8	NUM
bam-4803	366	5	.	.	PUNCT
bam-4803	366	6	60	60	NUM
bam-4803	366	7	.	.	PUNCT
bam-4803	367	1	yuchi	yuchi	PROPN
bam-4803	367	2	z	z	PROPN
bam-4803	367	3	,	,	PUNCT
bam-4803	367	4	lau	lau	PROPN
bam-4803	367	5	k	k	PROPN
bam-4803	367	6	,	,	PUNCT
bam-4803	367	7	van	van	PROPN
bam-4803	367	8	petegem	petegem	PROPN
bam-4803	367	9	f.	f.	PROPN
bam-4803	367	10	disease	disease	PROPN
bam-4803	367	11	mutations	mutation	NOUN
bam-4803	367	12	in	in	ADP
bam-4803	367	13	the	the	DET
bam-4803	367	14	ryanodine	ryanodine	NOUN
bam-4803	367	15	receptor	receptor	NOUN
bam-4803	367	16	central	central	ADJ
bam-4803	367	17	region	region	NOUN
bam-4803	367	18	:	:	PUNCT
bam-4803	367	19	crystal	crystal	NOUN
bam-4803	367	20	structures	structure	NOUN
bam-4803	367	21	of	of	ADP
bam-4803	367	22	a	a	DET
bam-4803	367	23	phosphorylation	phosphorylation	NOUN
bam-4803	367	24	hot	hot	ADJ
bam-4803	367	25	spot	spot	NOUN
bam-4803	367	26	domain	domain	NOUN
bam-4803	367	27	.	.	PUNCT
bam-4803	368	1	structure	structure	NOUN
bam-4803	368	2	2012;20:1201	2012;20:1201	NUM
bam-4803	368	3	-	-	SYM
bam-4803	368	4	11	11	NUM
bam-4803	368	5	.	.	PUNCT
bam-4803	368	6	61	61	NUM
bam-4803	368	7	.	.	PUNCT
bam-4803	368	8	egelman	egelman	PROPN
bam-4803	368	9	eh	eh	INTJ
bam-4803	368	10	.	.	PROPN
bam-4803	368	11	problems	problem	NOUN
bam-4803	368	12	in	in	ADP
bam-4803	368	13	fitting	fitting	ADJ
bam-4803	368	14	high	high	ADJ
bam-4803	368	15	resolution	resolution	NOUN
bam-4803	368	16	structures	structure	NOUN
bam-4803	368	17	into	into	ADP
bam-4803	368	18	electron	electron	NOUN
bam-4803	368	19	microscopic	microscopic	ADJ
bam-4803	368	20	reconstructions	reconstruction	NOUN
bam-4803	368	21	.	.	PUNCT
bam-4803	369	1	hfsp	hfsp	PROPN
bam-4803	369	2	j	j	PROPN
bam-4803	369	3	2008;2:324	2008;2:324	PROPN
bam-4803	369	4	-	-	SYM
bam-4803	369	5	31	31	NUM
bam-4803	369	6	.	.	PUNCT
bam-4803	370	1	62	62	NUM
bam-4803	370	2	.	.	PUNCT
bam-4803	371	1	meyerson	meyerson	PROPN
bam-4803	371	2	jr	jr	PROPN
bam-4803	371	3	,	,	PUNCT
bam-4803	371	4	kumar	kumar	PROPN
bam-4803	371	5	j	j	PROPN
bam-4803	371	6	,	,	PUNCT
bam-4803	371	7	chittori	chittori	PROPN
bam-4803	371	8	s	s	PROPN
bam-4803	371	9	,	,	PUNCT
bam-4803	371	10	et	et	PROPN
bam-4803	371	11	al	al	PROPN
bam-4803	371	12	.	.	PROPN
bam-4803	371	13	structural	structural	ADJ
bam-4803	371	14	mechanism	mechanism	NOUN
bam-4803	371	15	of	of	ADP
bam-4803	371	16	glutamate	glutamate	ADJ
bam-4803	371	17	receptor	receptor	NOUN
bam-4803	371	18	activation	activation	NOUN
bam-4803	371	19	and	and	CCONJ
bam-4803	371	20	desensitization	desensitization	NOUN
bam-4803	371	21	.	.	PUNCT
bam-4803	372	1	nature	nature	NOUN
bam-4803	372	2	2014;514(7522):328	2014;514(7522):328	NUM
bam-4803	372	3	-	-	SYM
bam-4803	372	4	34	34	NUM
bam-4803	372	5	.	.	PUNCT
bam-4803	372	6	63	63	NUM
bam-4803	372	7	.	.	PUNCT
bam-4803	373	1	seddon	seddon	PROPN
bam-4803	373	2	am	be	AUX
bam-4803	373	3	,	,	PUNCT
bam-4803	373	4	curnow	curnow	VERB
bam-4803	373	5	p	p	X
bam-4803	373	6	,	,	PUNCT
bam-4803	373	7	booth	booth	PROPN
bam-4803	373	8	pj	pj	PROPN
bam-4803	373	9	.	.	PUNCT
bam-4803	374	1	membrane	membrane	NOUN
bam-4803	374	2	proteins	protein	NOUN
bam-4803	374	3	,	,	PUNCT
bam-4803	374	4	lipids	lipid	NOUN
bam-4803	374	5	and	and	CCONJ
bam-4803	374	6	detergents	detergent	NOUN
bam-4803	374	7	:	:	PUNCT
bam-4803	374	8	not	not	PART
bam-4803	374	9	just	just	ADV
bam-4803	374	10	a	a	DET
bam-4803	374	11	soap	soap	NOUN
bam-4803	374	12	opera	opera	NOUN
bam-4803	374	13	.	.	PUNCT
bam-4803	375	1	biochim	biochim	PROPN
bam-4803	375	2	biophys	biophy	NOUN
bam-4803	375	3	acta	acta	PROPN
bam-4803	375	4	.	.	PUNCT
bam-4803	376	1	2004;1666:105	2004;1666:105	NUM
bam-4803	376	2	-	-	SYM
bam-4803	376	3	17	17	NUM
bam-4803	376	4	.	.	PUNCT
bam-4803	377	1	64	64	NUM
bam-4803	377	2	.	.	PUNCT
bam-4803	378	1	stewart	stewart	PROPN
bam-4803	378	2	a	a	PROPN
bam-4803	378	3	,	,	PUNCT
bam-4803	378	4	grigorieff	grigorieff	PROPN
bam-4803	378	5	n.	n.	NOUN
bam-4803	378	6	noise	noise	NOUN
bam-4803	378	7	bias	bias	NOUN
bam-4803	378	8	in	in	ADP
bam-4803	378	9	the	the	DET
bam-4803	378	10	refinement	refinement	NOUN
bam-4803	378	11	of	of	ADP
bam-4803	378	12	structures	structure	NOUN
bam-4803	378	13	derived	derive	VERB
bam-4803	378	14	from	from	ADP
bam-4803	378	15	single	single	ADJ
bam-4803	378	16	particles	particle	NOUN
bam-4803	378	17	.	.	PUNCT
bam-4803	379	1	ultramicroscopy	ultramicroscopy	NOUN
bam-4803	379	2	2004;102:67	2004;102:67	NOUN
bam-4803	379	3	-	-	SYM
bam-4803	379	4	84	84	NUM
bam-4803	379	5	.	.	PUNCT
bam-4803	379	6	65	65	NUM
bam-4803	379	7	.	.	PUNCT
bam-4803	380	1	serysheva	serysheva	PROPN
bam-4803	380	2	,	,	PUNCT
bam-4803	380	3	ii	ii	PROPN
bam-4803	380	4	,	,	PUNCT
bam-4803	380	5	chiu	chiu	PROPN
bam-4803	380	6	w	w	PROPN
bam-4803	380	7	,	,	PUNCT
bam-4803	380	8	ludtke	ludtke	PROPN
bam-4803	380	9	sj	sj	VERB
bam-4803	380	10	.	.	PUNCT
bam-4803	381	1	single	single	ADJ
bam-4803	381	2	-	-	PUNCT
bam-4803	381	3	particle	particle	NOUN
bam-4803	381	4	electron	electron	NOUN
bam-4803	381	5	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	381	6	of	of	ADP
bam-4803	381	7	the	the	DET
bam-4803	381	8	ion	ion	NOUN
bam-4803	381	9	channels	channel	NOUN
bam-4803	381	10	in	in	ADP
bam-4803	381	11	the	the	DET
bam-4803	381	12	excitation	excitation	NOUN
bam-4803	381	13	-	-	PUNCT
bam-4803	381	14	contraction	contraction	NOUN
bam-4803	381	15	coupling	couple	VERB
bam-4803	381	16	junction	junction	NOUN
bam-4803	381	17	.	.	PUNCT
bam-4803	382	1	methods	method	NOUN
bam-4803	382	2	cell	cell	VERB
bam-4803	382	3	biol	biol	PROPN
bam-4803	382	4	2007;79:407	2007;79:407	NOUN
bam-4803	382	5	-	-	SYM
bam-4803	382	6	35	35	NUM
bam-4803	382	7	.	.	PUNCT
bam-4803	383	1	66	66	NUM
bam-4803	383	2	.	.	PUNCT
bam-4803	384	1	cheung	cheung	PROPN
bam-4803	384	2	m	m	PROPN
bam-4803	384	3	,	,	PUNCT
bam-4803	384	4	kajimura	kajimura	ADJ
bam-4803	384	5	n	n	CCONJ
bam-4803	384	6	,	,	PUNCT
bam-4803	384	7	makino	makino	PROPN
bam-4803	384	8	f	f	PROPN
bam-4803	384	9	,	,	PUNCT
bam-4803	384	10	et	et	PROPN
bam-4803	384	11	al	al	PROPN
bam-4803	384	12	.	.	PUNCT
bam-4803	385	1	a	a	DET
bam-4803	385	2	method	method	NOUN
bam-4803	385	3	to	to	PART
bam-4803	385	4	achieve	achieve	VERB
bam-4803	385	5	homogeneous	homogeneous	ADJ
bam-4803	385	6	dispersion	dispersion	NOUN
bam-4803	385	7	of	of	ADP
bam-4803	385	8	large	large	ADJ
bam-4803	385	9	transmembrane	transmembrane	NOUN
bam-4803	385	10	complexes	complex	NOUN
bam-4803	385	11	within	within	ADP
bam-4803	385	12	the	the	DET
bam-4803	385	13	holes	hole	NOUN
bam-4803	385	14	of	of	ADP
bam-4803	385	15	carbon	carbon	NOUN
bam-4803	385	16	films	film	NOUN
bam-4803	385	17	for	for	ADP
bam-4803	385	18	electron	electron	NOUN
bam-4803	385	19	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	385	20	.	.	PUNCT
bam-4803	386	1	j	j	PROPN
bam-4803	386	2	struct	struct	VERB
bam-4803	386	3	biol	biol	PROPN
bam-4803	386	4	2013;182:51	2013;182:51	NOUN
bam-4803	386	5	-	-	SYM
bam-4803	386	6	6	6	NUM
bam-4803	386	7	.	.	NOUN
bam-4803	386	8	67	67	NUM
bam-4803	386	9	.	.	PUNCT
bam-4803	387	1	kelly	kelly	PROPN
bam-4803	387	2	df	df	PROPN
bam-4803	387	3	,	,	PUNCT
bam-4803	387	4	dukovski	dukovski	VERB
bam-4803	387	5	d	d	PROPN
bam-4803	387	6	,	,	PUNCT
bam-4803	387	7	walz	walz	PROPN
bam-4803	387	8	t.	t.	PROPN
bam-4803	387	9	strategy	strategy	NOUN
bam-4803	387	10	for	for	ADP
bam-4803	387	11	the	the	DET
bam-4803	387	12	use	use	NOUN
bam-4803	387	13	of	of	ADP
bam-4803	387	14	affinity	affinity	NOUN
bam-4803	387	15	grids	grid	NOUN
bam-4803	387	16	to	to	PART
bam-4803	387	17	prepare	prepare	VERB
bam-4803	387	18	non	non	ADJ
bam-4803	387	19	-	-	ADJ
bam-4803	387	20	his	his	PRON
bam-4803	387	21	-	-	PUNCT
bam-4803	387	22	tagged	tag	VERB
bam-4803	387	23	macromolecular	macromolecular	NOUN
bam-4803	387	24	complexes	complex	NOUN
bam-4803	387	25	for	for	ADP
bam-4803	387	26	single	single	ADJ
bam-4803	387	27	-	-	PUNCT
bam-4803	387	28	particle	particle	NOUN
bam-4803	387	29	electron	electron	NOUN
bam-4803	387	30	microscopy	microscopy	NOUN
bam-4803	387	31	.	.	PUNCT
bam-4803	388	1	j	j	PROPN
bam-4803	388	2	mol	mol	ADP
bam-4803	388	3	biol	biol	PROPN
bam-4803	388	4	2010;400:67581	2010;400:67581	NUM
bam-4803	388	5	.	.	PUNCT
bam-4803	389	1	68	68	NUM
bam-4803	389	2	.	.	PUNCT
bam-4803	390	1	kastner	kastner	PROPN
bam-4803	390	2	b	b	PROPN
bam-4803	390	3	,	,	PUNCT
bam-4803	390	4	fischer	fischer	PROPN
bam-4803	390	5	n	n	CCONJ
bam-4803	390	6	,	,	PUNCT
bam-4803	390	7	golas	golas	X
bam-4803	390	8	mm	mm	PROPN
bam-4803	390	9	,	,	PUNCT
bam-4803	390	10	et	et	PROPN
bam-4803	390	11	al	al	PROPN
bam-4803	390	12	.	.	PUNCT
bam-4803	390	13	grafix	grafix	PROPN
bam-4803	390	14	:	:	PUNCT
bam-4803	390	15	sample	sample	NOUN
bam-4803	390	16	preparation	preparation	NOUN
bam-4803	390	17	for	for	ADP
bam-4803	390	18	single	single	ADJ
bam-4803	390	19	-	-	PUNCT
bam-4803	390	20	particle	particle	NOUN
bam-4803	390	21	electron	electron	NOUN
bam-4803	390	22	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	390	23	.	.	PUNCT
bam-4803	391	1	nat	nat	PROPN
bam-4803	391	2	methods	method	NOUN
bam-4803	391	3	2008;5:53	2008;5:53	NOUN
bam-4803	391	4	-	-	SYM
bam-4803	391	5	5	5	NUM
bam-4803	391	6	.	.	NUM
bam-4803	391	7	69	69	NUM
bam-4803	391	8	.	.	PUNCT
bam-4803	392	1	popot	popot	NOUN
bam-4803	392	2	jl	jl	PROPN
bam-4803	392	3	.	.	PUNCT
bam-4803	392	4	amphipols	amphipol	NOUN
bam-4803	392	5	,	,	PUNCT
bam-4803	392	6	nanodiscs	nanodiscs	ADJ
bam-4803	392	7	,	,	PUNCT
bam-4803	392	8	and	and	CCONJ
bam-4803	392	9	fluorinated	fluorinate	VERB
bam-4803	392	10	surfactants	surfactant	NOUN
bam-4803	392	11	:	:	PUNCT
bam-4803	392	12	three	three	NUM
bam-4803	392	13	nonconventional	nonconventional	ADJ
bam-4803	392	14	approaches	approach	NOUN
bam-4803	392	15	to	to	ADP
bam-4803	392	16	studying	study	VERB
bam-4803	392	17	membrane	membrane	ADJ
bam-4803	392	18	proteins	protein	NOUN
bam-4803	392	19	in	in	ADP
bam-4803	392	20	aqueous	aqueous	ADJ
bam-4803	392	21	solutions	solution	NOUN
bam-4803	392	22	.	.	PUNCT
bam-4803	393	1	ann	ann	PROPN
bam-4803	393	2	rev	rev	VERB
bam-4803	393	3	biochem	biochem	PROPN
bam-4803	393	4	2010;79:737	2010;79:737	PROPN
bam-4803	393	5	-	-	SYM
bam-4803	393	6	75	75	NUM
bam-4803	393	7	.	.	PUNCT
bam-4803	394	1	70	70	NUM
bam-4803	394	2	.	.	PUNCT
bam-4803	395	1	tribet	tribet	PROPN
bam-4803	395	2	c	c	PROPN
bam-4803	395	3	,	,	PUNCT
bam-4803	395	4	audebert	audebert	ADJ
bam-4803	395	5	r	r	NOUN
bam-4803	395	6	,	,	PUNCT
bam-4803	395	7	popot	popot	NOUN
bam-4803	395	8	jl	jl	PROPN
bam-4803	395	9	.	.	PUNCT
bam-4803	396	1	amphipols	amphipol	NOUN
bam-4803	396	2	:	:	PUNCT
bam-4803	396	3	polymers	polymer	NOUN
bam-4803	396	4	that	that	PRON
bam-4803	396	5	keep	keep	VERB
bam-4803	396	6	membrane	membrane	NOUN
bam-4803	396	7	proteins	protein	NOUN
bam-4803	396	8	soluble	soluble	ADJ
bam-4803	396	9	in	in	ADP
bam-4803	396	10	aqueous	aqueous	ADJ
bam-4803	396	11	solutions	solution	NOUN
bam-4803	396	12	.	.	PUNCT
bam-4803	397	1	proc	proc	PROPN
bam-4803	397	2	natl	natl	PROPN
bam-4803	397	3	acad	acad	PROPN
bam-4803	397	4	sci	sci	PROPN
bam-4803	397	5	u	u	PROPN
bam-4803	397	6	s	s	PROPN
bam-4803	397	7	a	a	DET
bam-4803	397	8	1996;93:15047	1996;93:15047	NUM
bam-4803	397	9	-	-	SYM
bam-4803	397	10	50	50	NUM
bam-4803	397	11	.	.	PUNCT
bam-4803	398	1	71	71	NUM
bam-4803	398	2	.	.	PUNCT
bam-4803	398	3	popot	popot	NOUN
bam-4803	398	4	jl	jl	PROPN
bam-4803	398	5	,	,	PUNCT
bam-4803	398	6	berry	berry	NOUN
bam-4803	398	7	ea	ea	NOUN
bam-4803	398	8	,	,	PUNCT
bam-4803	398	9	charvolin	charvolin	NOUN
bam-4803	398	10	d	d	PROPN
bam-4803	398	11	,	,	PUNCT
bam-4803	398	12	creuzenet	creuzenet	PROPN
bam-4803	398	13	c	c	NOUN
bam-4803	398	14	,	,	PUNCT
bam-4803	398	15	ebel	ebel	PROPN
bam-4803	398	16	c	c	X
bam-4803	398	17	,	,	PUNCT
bam-4803	398	18	engelman	engelman	PROPN
bam-4803	398	19	dm	dm	PROPN
bam-4803	398	20	,	,	PUNCT
bam-4803	398	21	et	et	PROPN
bam-4803	398	22	al	al	PROPN
bam-4803	398	23	.	.	PROPN
bam-4803	399	1	amphipols	amphipol	NOUN
bam-4803	399	2	:	:	PUNCT
bam-4803	399	3	polymeric	polymeric	ADJ
bam-4803	399	4	surfactants	surfactant	NOUN
bam-4803	399	5	for	for	ADP
bam-4803	399	6	membrane	membrane	NOUN
bam-4803	399	7	biology	biology	NOUN
bam-4803	399	8	research	research	NOUN
bam-4803	399	9	.	.	PUNCT
bam-4803	400	1	cell	cell	NOUN
bam-4803	400	2	mol	mol	ADP
bam-4803	400	3	life	life	NOUN
bam-4803	400	4	sci	sci	PROPN
bam-4803	400	5	2003;60(8):1559	2003;60(8):1559	PROPN
bam-4803	400	6	-	-	SYM
bam-4803	400	7	74	74	NUM
bam-4803	400	8	.	.	PUNCT
bam-4803	401	1	72	72	NUM
bam-4803	401	2	.	.	PUNCT
bam-4803	402	1	tribet	tribet	PROPN
bam-4803	402	2	c	c	PROPN
bam-4803	402	3	,	,	PUNCT
bam-4803	402	4	diab	diab	PROPN
bam-4803	402	5	c	c	NOUN
bam-4803	402	6	,	,	PUNCT
bam-4803	402	7	dahmane	dahmane	NOUN
bam-4803	402	8	t	t	PROPN
bam-4803	402	9	,	,	PUNCT
bam-4803	402	10	et	et	PROPN
bam-4803	402	11	al	al	PROPN
bam-4803	402	12	.	.	PUNCT
bam-4803	403	1	thermodynamic	thermodynamic	ADJ
bam-4803	403	2	characterization	characterization	NOUN
bam-4803	403	3	of	of	ADP
bam-4803	403	4	the	the	DET
bam-4803	403	5	exchange	exchange	NOUN
bam-4803	403	6	of	of	ADP
bam-4803	403	7	detergents	detergent	NOUN
bam-4803	403	8	and	and	CCONJ
bam-4803	403	9	amphipols	amphipol	NOUN
bam-4803	403	10	at	at	ADP
bam-4803	403	11	the	the	DET
bam-4803	403	12	surfaces	surface	NOUN
bam-4803	403	13	of	of	ADP
bam-4803	403	14	integral	integral	ADJ
bam-4803	403	15	membrane	membrane	NOUN
bam-4803	403	16	proteins	protein	NOUN
bam-4803	403	17	.	.	PUNCT
bam-4803	404	1	langmuir	langmuir	PROPN
bam-4803	404	2	2009;25:12623	2009;25:12623	PROPN
bam-4803	404	3	-	-	SYM
bam-4803	404	4	34	34	NUM
bam-4803	404	5	.	.	PUNCT
bam-4803	405	1	73	73	NUM
bam-4803	405	2	.	.	PUNCT
bam-4803	406	1	champeil	champeil	VERB
bam-4803	406	2	p	p	NOUN
bam-4803	406	3	,	,	PUNCT
bam-4803	406	4	menguy	menguy	NOUN
bam-4803	406	5	t	t	PROPN
bam-4803	406	6	,	,	PUNCT
bam-4803	406	7	tribet	tribet	PROPN
bam-4803	406	8	c	c	PROPN
bam-4803	406	9	,	,	PUNCT
bam-4803	406	10	et	et	PROPN
bam-4803	406	11	al	al	PROPN
bam-4803	406	12	.	.	PUNCT
bam-4803	406	13	interaction	interaction	NOUN
bam-4803	406	14	of	of	ADP
bam-4803	406	15	amphipols	amphipol	NOUN
bam-4803	406	16	with	with	ADP
bam-4803	406	17	sarcoplasmic	sarcoplasmic	ADJ
bam-4803	406	18	reticulum	reticulum	NOUN
bam-4803	406	19	ca	ca	NOUN
bam-4803	406	20	2	2	NUM
bam-4803	406	21	+	+	NUM
bam-4803	406	22	-atpase	-atpase	NOUN
bam-4803	406	23	.	.	PUNCT
bam-4803	407	1	j	j	PROPN
bam-4803	407	2	biol	biol	PROPN
bam-4803	407	3	chem	chem	NOUN
bam-4803	407	4	2000;275:18623	2000;275:18623	NUM
bam-4803	407	5	-	-	SYM
bam-4803	407	6	37	37	NUM
bam-4803	407	7	.	.	PUNCT
bam-4803	408	1	74	74	NUM
bam-4803	408	2	.	.	PUNCT
bam-4803	409	1	picard	picard	PROPN
bam-4803	409	2	m	m	PROPN
bam-4803	409	3	,	,	PUNCT
bam-4803	409	4	dahmane	dahmane	PROPN
bam-4803	409	5	t	t	PROPN
bam-4803	409	6	,	,	PUNCT
bam-4803	409	7	garrigos	garrigo	NOUN
bam-4803	409	8	m	m	PRON
bam-4803	409	9	,	,	PUNCT
bam-4803	409	10	et	et	PROPN
bam-4803	409	11	al	al	PROPN
bam-4803	409	12	.	.	PROPN
bam-4803	410	1	protective	protective	ADJ
bam-4803	410	2	and	and	CCONJ
bam-4803	410	3	inhibitory	inhibitory	ADJ
bam-4803	410	4	effects	effect	NOUN
bam-4803	410	5	of	of	ADP
bam-4803	410	6	various	various	ADJ
bam-4803	410	7	types	type	NOUN
bam-4803	410	8	of	of	ADP
bam-4803	410	9	amphipols	amphipol	NOUN
bam-4803	410	10	on	on	ADP
bam-4803	410	11	the	the	DET
bam-4803	410	12	ca	ca	NOUN
bam-4803	410	13	2	2	NUM
bam-4803	410	14	+	+	NUM
bam-4803	410	15	-atpase	-atpase	NOUN
bam-4803	410	16	from	from	ADP
bam-4803	410	17	sarcoplasmic	sarcoplasmic	ADJ
bam-4803	410	18	reticulum	reticulum	NOUN
bam-4803	410	19	:	:	PUNCT
bam-4803	410	20	a	a	DET
bam-4803	410	21	comparative	comparative	ADJ
bam-4803	410	22	study	study	NOUN
bam-4803	410	23	.	.	PUNCT
bam-4803	411	1	biochemistry	biochemistry	NOUN
bam-4803	411	2	2006;45:1861	2006;45:1861	NUM
bam-4803	411	3	-	-	SYM
bam-4803	411	4	9	9	NUM
bam-4803	411	5	.	.	X
bam-4803	411	6	75	75	NUM
bam-4803	411	7	.	.	PUNCT
bam-4803	412	1	pocanschi	pocanschi	PROPN
bam-4803	412	2	cl	cl	PROPN
bam-4803	412	3	,	,	PUNCT
bam-4803	412	4	dahmane	dahmane	NOUN
bam-4803	412	5	t	t	PROPN
bam-4803	412	6	,	,	PUNCT
bam-4803	412	7	gohon	gohon	PROPN
bam-4803	412	8	y	y	PROPN
bam-4803	412	9	,	,	PUNCT
bam-4803	412	10	et	et	PROPN
bam-4803	412	11	al	al	PROPN
bam-4803	412	12	.	.	PUNCT
bam-4803	413	1	amphipathic	amphipathic	ADJ
bam-4803	413	2	polymers	polymer	NOUN
bam-4803	413	3	:	:	PUNCT
bam-4803	413	4	tools	tool	NOUN
bam-4803	413	5	to	to	PART
bam-4803	413	6	fold	fold	VERB
bam-4803	413	7	integral	integral	ADJ
bam-4803	413	8	membrane	membrane	NOUN
bam-4803	413	9	proteins	protein	NOUN
bam-4803	413	10	to	to	ADP
bam-4803	413	11	their	their	PRON
bam-4803	413	12	active	active	ADJ
bam-4803	413	13	form	form	NOUN
bam-4803	413	14	.	.	PUNCT
bam-4803	414	1	biochemistry	biochemistry	NOUN
bam-4803	414	2	2006;45:13954	2006;45:13954	NUM
bam-4803	414	3	-	-	SYM
bam-4803	414	4	61	61	NUM
bam-4803	414	5	.	.	PUNCT
bam-4803	414	6	76	76	NUM
bam-4803	414	7	.	.	PUNCT
bam-4803	415	1	popova	popova	PROPN
bam-4803	415	2	ob	ob	PROPN
bam-4803	415	3	,	,	PUNCT
bam-4803	415	4	fan	fan	NOUN
bam-4803	415	5	g	g	PROPN
bam-4803	415	6	,	,	PUNCT
bam-4803	415	7	chiu	chiu	PROPN
bam-4803	415	8	w	w	PROPN
bam-4803	415	9	,	,	PUNCT
bam-4803	415	10	et	et	PROPN
bam-4803	415	11	al	al	PROPN
bam-4803	415	12	.	.	PUNCT
bam-4803	416	1	cryo	cryo	PROPN
bam-4803	416	2	-	-	PUNCT
bam-4803	416	3	em	em	PRON
bam-4803	416	4	studies	study	NOUN
bam-4803	416	5	of	of	ADP
bam-4803	416	6	ryr1	ryr1	PROPN
bam-4803	416	7	channel	channel	NOUN
bam-4803	416	8	in	in	ADP
bam-4803	416	9	detergent	detergent	NOUN
bam-4803	416	10	-	-	PUNCT
bam-4803	416	11	free	free	ADJ
bam-4803	416	12	aqueous	aqueous	ADJ
bam-4803	416	13	environment	environment	NOUN
bam-4803	416	14	.	.	PUNCT
bam-4803	417	1	biophys	biophys	PROPN
bam-4803	417	2	j	j	PROPN
bam-4803	417	3	2014;106:109	2014;106:109	NUM
bam-4803	417	4	.	.	PROPN
bam-4803	418	1	77	77	NUM
bam-4803	418	2	.	.	PUNCT
bam-4803	419	1	fan	fan	PROPN
bam-4803	419	2	g	g	PROPN
bam-4803	419	3	,	,	PUNCT
bam-4803	419	4	gonzalez	gonzalez	PROPN
bam-4803	419	5	j	j	PROPN
bam-4803	419	6	,	,	PUNCT
bam-4803	419	7	popova	popova	X
bam-4803	419	8	ob	ob	PROPN
bam-4803	419	9	,	,	PUNCT
bam-4803	419	10	et	et	PROPN
bam-4803	419	11	al	al	PROPN
bam-4803	419	12	.	.	PUNCT
bam-4803	420	1	a	a	DET
bam-4803	420	2	first	first	ADJ
bam-4803	420	3	look	look	NOUN
bam-4803	420	4	into	into	ADP
bam-4803	420	5	the	the	DET
bam-4803	420	6	3d	3d	NUM
bam-4803	420	7	structure	structure	NOUN
bam-4803	420	8	of	of	ADP
bam-4803	420	9	the	the	DET
bam-4803	420	10	trpv2	trpv2	NOUN
bam-4803	420	11	channel	channel	NOUN
bam-4803	420	12	by	by	ADP
bam-4803	420	13	single	single	ADJ
bam-4803	420	14	-	-	PUNCT
bam-4803	420	15	particle	particle	NOUN
bam-4803	420	16	cryo	cryo	NOUN
bam-4803	420	17	-	-	PUNCT
bam-4803	420	18	em	em	PROPN
bam-4803	420	19	.	.	PROPN
bam-4803	420	20	biophys	biophys	PROPN
bam-4803	420	21	j	j	PROPN
bam-4803	420	22	2014;106:600a-1a	2014;106:600a-1a	NUM
bam-4803	420	23	.	.	PROPN
bam-4803	420	24	78	78	NUM
bam-4803	420	25	.	.	PUNCT
bam-4803	421	1	hauser	hauser	PROPN
bam-4803	421	2	h.	h.	PROPN
bam-4803	421	3	short	short	PROPN
bam-4803	421	4	-	-	PUNCT
bam-4803	421	5	chain	chain	NOUN
bam-4803	421	6	phospholipids	phospholipid	NOUN
bam-4803	421	7	as	as	ADP
bam-4803	421	8	detergents	detergent	NOUN
bam-4803	421	9	.	.	PUNCT
bam-4803	422	1	biochim	biochim	PROPN
bam-4803	422	2	biophys	biophy	NOUN
bam-4803	422	3	acta	acta	VERB
bam-4803	422	4	2000;1508:164	2000;1508:164	PROPN
bam-4803	422	5	-	-	PUNCT
bam-4803	422	6	81	81	NUM
bam-4803	422	7	.	.	PUNCT
bam-4803	423	1	79	79	NUM
bam-4803	423	2	.	.	PUNCT
bam-4803	424	1	kessi	kessi	PROPN
bam-4803	424	2	j	j	PROPN
bam-4803	424	3	,	,	PUNCT
bam-4803	424	4	poiree	poiree	PROPN
bam-4803	424	5	jc	jc	PROPN
bam-4803	424	6	,	,	PUNCT
bam-4803	424	7	wehrli	wehrli	NOUN
bam-4803	424	8	e	e	NOUN
bam-4803	424	9	,	,	PUNCT
bam-4803	424	10	et	et	PROPN
bam-4803	424	11	al	al	PROPN
bam-4803	424	12	short	short	ADJ
bam-4803	424	13	-	-	PUNCT
bam-4803	424	14	chain	chain	NOUN
bam-4803	424	15	phosphatidylcholines	phosphatidylcholine	NOUN
bam-4803	424	16	as	as	ADP
bam-4803	424	17	superior	superior	ADJ
bam-4803	424	18	detergents	detergent	NOUN
bam-4803	424	19	in	in	ADP
bam-4803	424	20	solubilizing	solubilize	VERB
bam-4803	424	21	membrane	membrane	NOUN
bam-4803	424	22	proteins	protein	NOUN
bam-4803	424	23	and	and	CCONJ
bam-4803	424	24	preserving	preserve	VERB
bam-4803	424	25	biological	biological	ADJ
bam-4803	424	26	activity	activity	NOUN
bam-4803	424	27	.	.	PUNCT
bam-4803	425	1	biochemistry	biochemistry	NOUN
bam-4803	425	2	1994;33:1082536	1994;33:1082536	NUM
bam-4803	425	3	.	.	PUNCT
bam-4803	425	4	80	80	NUM
bam-4803	425	5	.	.	PUNCT
bam-4803	426	1	wang	wang	PROPN
bam-4803	426	2	jp	jp	PROPN
bam-4803	426	3	,	,	PUNCT
bam-4803	426	4	needleman	needleman	PROPN
bam-4803	426	5	dh	dh	PROPN
bam-4803	426	6	,	,	PUNCT
bam-4803	426	7	hamilton	hamilton	PROPN
bam-4803	426	8	sl	sl	PROPN
bam-4803	426	9	.	.	PROPN
bam-4803	426	10	relationship	relationship	NOUN
bam-4803	426	11	of	of	ADP
bam-4803	426	12	low	low	ADJ
bam-4803	426	13	affinity	affinity	NOUN
bam-4803	426	14	[	[	X
bam-4803	426	15	3]ryanodine	3]ryanodine	NUM
bam-4803	426	16	binding	bind	VERB
bam-4803	426	17	sites	site	NOUN
bam-4803	426	18	to	to	ADP
bam-4803	426	19	high	high	ADJ
bam-4803	426	20	affinity	affinity	NOUN
bam-4803	426	21	sites	site	NOUN
bam-4803	426	22	on	on	ADP
bam-4803	426	23	the	the	DET
bam-4803	426	24	skeletal	skeletal	ADJ
bam-4803	426	25	muscle	muscle	NOUN
bam-4803	426	26	ca	ca	NOUN
bam-4803	426	27	2	2	NUM
bam-4803	426	28	+	+	NOUN
bam-4803	426	29	release	release	NOUN
bam-4803	426	30	channel	channel	NOUN
bam-4803	426	31	.	.	PUNCT
bam-4803	427	1	j	j	PROPN
bam-4803	427	2	biol	biol	PROPN
bam-4803	427	3	chem	chem	NOUN
bam-4803	427	4	1993;268:20974	1993;268:20974	NUM
bam-4803	427	5	-	-	SYM
bam-4803	427	6	82	82	NUM
bam-4803	427	7	.	.	PUNCT
bam-4803	427	8	81	81	NUM
bam-4803	427	9	.	.	PUNCT
bam-4803	428	1	callaway	callaway	PROPN
bam-4803	428	2	c	c	PROPN
bam-4803	428	3	,	,	PUNCT
bam-4803	428	4	seryshev	seryshev	PROPN
bam-4803	428	5	a	a	PRON
bam-4803	428	6	,	,	PUNCT
bam-4803	428	7	wang	wang	PROPN
bam-4803	428	8	jp	jp	PROPN
bam-4803	428	9	,	,	PUNCT
bam-4803	428	10	et	et	PROPN
bam-4803	428	11	al	al	PROPN
bam-4803	428	12	.	.	PUNCT
bam-4803	428	13	localization	localization	NOUN
bam-4803	428	14	of	of	ADP
bam-4803	428	15	the	the	DET
bam-4803	428	16	high	high	ADJ
bam-4803	428	17	and	and	CCONJ
bam-4803	428	18	low	low	ADJ
bam-4803	428	19	affinity	affinity	NOUN
bam-4803	428	20	[	[	X
bam-4803	428	21	3h]ryanodine	3h]ryanodine	NUM
bam-4803	428	22	binding	bind	VERB
bam-4803	428	23	sites	site	NOUN
bam-4803	428	24	on	on	ADP
bam-4803	428	25	the	the	DET
bam-4803	428	26	skeletal	skeletal	ADJ
bam-4803	428	27	muscle	muscle	NOUN
bam-4803	428	28	ca	ca	NOUN
bam-4803	428	29	2	2	NUM
bam-4803	428	30	+	+	NOUN
bam-4803	428	31	release	release	NOUN
bam-4803	428	32	channel	channel	NOUN
bam-4803	428	33	.	.	PUNCT
bam-4803	429	1	j	j	PROPN
bam-4803	429	2	biol	biol	PROPN
bam-4803	429	3	chem	chem	NOUN
bam-4803	429	4	1994;269:15876	1994;269:15876	NUM
bam-4803	429	5	-	-	SYM
bam-4803	429	6	84	84	NUM
bam-4803	429	7	.	.	PUNCT
bam-4803	430	1	single	single	ADJ
bam-4803	430	2	-	-	PUNCT
bam-4803	430	3	particle	particle	NOUN
bam-4803	430	4	cryo	cryo	NOUN
bam-4803	430	5	-	-	PUNCT
bam-4803	430	6	em	em	PRON
bam-4803	430	7	of	of	ADP
bam-4803	430	8	the	the	DET
bam-4803	430	9	ryanodine	ryanodine	PROPN
bam-4803	430	10	receptor	receptor	NOUN
bam-4803	430	11	channel	channel	PROPN
bam-4803	430	12	eur	eur	PROPN
bam-4803	430	13	j	j	PROPN
bam-4803	430	14	transl	transl	PROPN
bam-4803	430	15	myol	myol	PROPN
bam-4803	430	16	basic	basic	ADJ
bam-4803	430	17	appl	appl	NOUN
bam-4803	430	18	myol	myol	NOUN
bam-4803	430	19	2015	2015	NUM
bam-4803	430	20	;	;	PUNCT
bam-4803	430	21	25	25	NUM
bam-4803	430	22	(	(	PUNCT
bam-4803	430	23	1	1	NUM
bam-4803	430	24	):	):	PUNCT
bam-4803	430	25	35	35	NUM
bam-4803	430	26	-	-	SYM
bam-4803	430	27	48	48	NUM
bam-4803	430	28	48	48	NUM
bam-4803	430	29	82	82	NUM
bam-4803	430	30	.	.	PUNCT
bam-4803	431	1	lobo	lobo	PROPN
bam-4803	431	2	pa	pa	PROPN
bam-4803	431	3	,	,	PUNCT
bam-4803	431	4	van	van	PROPN
bam-4803	431	5	petegem	petegem	PROPN
bam-4803	431	6	f.	f.	PROPN
bam-4803	431	7	crystal	crystal	PROPN
bam-4803	431	8	structures	structure	NOUN
bam-4803	431	9	of	of	ADP
bam-4803	431	10	the	the	DET
bam-4803	431	11	n	n	CCONJ
bam-4803	431	12	-	-	PUNCT
bam-4803	431	13	terminal	terminal	ADJ
bam-4803	431	14	domains	domain	NOUN
bam-4803	431	15	of	of	ADP
bam-4803	431	16	cardiac	cardiac	ADJ
bam-4803	431	17	and	and	CCONJ
bam-4803	431	18	skeletal	skeletal	ADJ
bam-4803	431	19	muscle	muscle	NOUN
bam-4803	431	20	ryanodine	ryanodine	NOUN
bam-4803	431	21	receptors	receptor	NOUN
bam-4803	431	22	:	:	PUNCT
bam-4803	431	23	insights	insight	NOUN
bam-4803	431	24	into	into	ADP
bam-4803	431	25	disease	disease	NOUN
bam-4803	431	26	mutations	mutation	NOUN
bam-4803	431	27	.	.	PUNCT
bam-4803	432	1	structure	structure	NOUN
bam-4803	432	2	2009;17:1505	2009;17:1505	NUM
bam-4803	432	3	-	-	SYM
bam-4803	432	4	14	14	NUM
bam-4803	432	5	.	.	PUNCT
bam-4803	432	6	83	83	NUM
bam-4803	432	7	.	.	PUNCT
bam-4803	433	1	jiang	jiang	PROPN
bam-4803	433	2	qx	qx	PROPN
bam-4803	433	3	,	,	PUNCT
bam-4803	433	4	thrower	thrower	NOUN
bam-4803	433	5	ec	ec	PROPN
bam-4803	433	6	,	,	PUNCT
bam-4803	433	7	chester	chester	PROPN
bam-4803	433	8	dw	dw	PROPN
bam-4803	433	9	,	,	PUNCT
bam-4803	433	10	et	et	PROPN
bam-4803	433	11	al	al	PROPN
bam-4803	433	12	.	.	PROPN
bam-4803	433	13	threedimensional	threedimensional	ADJ
bam-4803	433	14	structure	structure	NOUN
bam-4803	433	15	of	of	ADP
bam-4803	433	16	the	the	DET
bam-4803	433	17	type	type	NOUN
bam-4803	433	18	1	1	NUM
bam-4803	433	19	inositol	inositol	NOUN
bam-4803	433	20	1,4,5trisphosphate	1,4,5trisphosphate	NUM
bam-4803	433	21	receptor	receptor	NOUN
bam-4803	433	22	at	at	ADP
bam-4803	433	23	24	24	NUM
bam-4803	433	24	å	å	PROPN
bam-4803	433	25	resolution	resolution	NOUN
bam-4803	433	26	.	.	PUNCT
bam-4803	434	1	embo	embo	PROPN
bam-4803	434	2	j	j	PROPN
bam-4803	434	3	2002;21:3575	2002;21:3575	NUM
bam-4803	434	4	-	-	SYM
bam-4803	434	5	81	81	NUM
bam-4803	434	6	.	.	PUNCT
bam-4803	434	7	84	84	NUM
bam-4803	434	8	.	.	PUNCT
bam-4803	435	1	serysheva	serysheva	PROPN
bam-4803	435	2	,	,	PUNCT
bam-4803	435	3	ii	ii	PROPN
bam-4803	435	4	,	,	PUNCT
bam-4803	435	5	bare	bare	ADJ
bam-4803	435	6	dj	dj	NOUN
bam-4803	435	7	,	,	PUNCT
bam-4803	435	8	ludtke	ludtke	NOUN
bam-4803	435	9	sj	sj	PROPN
bam-4803	435	10	,	,	PUNCT
bam-4803	435	11	et	et	PROPN
bam-4803	435	12	al	al	PROPN
bam-4803	435	13	.	.	PUNCT
bam-4803	435	14	structure	structure	NOUN
bam-4803	435	15	of	of	ADP
bam-4803	435	16	the	the	DET
bam-4803	435	17	type	type	NOUN
bam-4803	435	18	1	1	NUM
bam-4803	435	19	inositol	inositol	NOUN
bam-4803	435	20	1,4,5	1,4,5	NUM
bam-4803	435	21	-	-	PUNCT
bam-4803	435	22	trisphosphate	trisphosphate	ADJ
bam-4803	435	23	receptor	receptor	NOUN
bam-4803	435	24	revealed	reveal	VERB
bam-4803	435	25	by	by	ADP
bam-4803	435	26	electron	electron	NOUN
bam-4803	435	27	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	435	28	.	.	PUNCT
bam-4803	436	1	j	j	PROPN
bam-4803	436	2	biol	biol	PROPN
bam-4803	436	3	chem	chem	NOUN
bam-4803	436	4	2003;278:21319	2003;278:21319	NUM
bam-4803	436	5	-	-	SYM
bam-4803	436	6	22	22	NUM
bam-4803	436	7	.	.	PUNCT
bam-4803	436	8	85	85	NUM
bam-4803	436	9	.	.	PUNCT
bam-4803	437	1	ludtke	ludtke	PROPN
bam-4803	437	2	sj	sj	PROPN
bam-4803	437	3	,	,	PUNCT
bam-4803	437	4	tran	tran	PROPN
bam-4803	437	5	tp	tp	PROPN
bam-4803	437	6	,	,	PUNCT
bam-4803	437	7	ngo	ngo	PROPN
bam-4803	437	8	qt	qt	PROPN
bam-4803	437	9	,	,	PUNCT
bam-4803	437	10	et	et	PROPN
bam-4803	437	11	al	al	PROPN
bam-4803	437	12	.	.	PROPN
bam-4803	437	13	flexible	flexible	ADJ
bam-4803	437	14	architecture	architecture	NOUN
bam-4803	437	15	of	of	ADP
bam-4803	437	16	ip	ip	NOUN
bam-4803	437	17	3	3	NUM
bam-4803	437	18	r1	r1	NOUN
bam-4803	437	19	by	by	ADP
bam-4803	437	20	cryo	cryo	PROPN
bam-4803	437	21	-	-	PUNCT
bam-4803	437	22	em	em	PROPN
bam-4803	437	23	.	.	PUNCT
bam-4803	437	24	structure	structure	PROPN
bam-4803	437	25	2011;19:1192	2011;19:1192	NUM
bam-4803	437	26	-	-	SYM
bam-4803	437	27	9	9	NUM
bam-4803	437	28	.	.	NOUN
bam-4803	437	29	86	86	NUM
bam-4803	437	30	.	.	PUNCT
bam-4803	438	1	sato	sato	PROPN
bam-4803	438	2	c	c	PROPN
bam-4803	438	3	,	,	PUNCT
bam-4803	438	4	hamada	hamada	PROPN
bam-4803	438	5	k	k	PROPN
bam-4803	438	6	,	,	PUNCT
bam-4803	438	7	ogura	ogura	PROPN
bam-4803	438	8	t	t	PROPN
bam-4803	438	9	,	,	PUNCT
bam-4803	438	10	et	et	PROPN
bam-4803	438	11	al	al	PROPN
bam-4803	438	12	.	.	PROPN
bam-4803	439	1	inositol	inositol	NOUN
bam-4803	439	2	1,4,5trisphosphate	1,4,5trisphosphate	NUM
bam-4803	439	3	receptor	receptor	NOUN
bam-4803	439	4	contains	contain	VERB
bam-4803	439	5	multiple	multiple	ADJ
bam-4803	439	6	cavities	cavity	NOUN
bam-4803	439	7	and	and	CCONJ
bam-4803	439	8	l	l	NOUN
bam-4803	439	9	-	-	ADJ
bam-4803	439	10	shaped	shape	VERB
bam-4803	439	11	ligand	ligand	NOUN
bam-4803	439	12	-	-	PUNCT
bam-4803	439	13	binding	bind	VERB
bam-4803	439	14	domains	domain	NOUN
bam-4803	439	15	.	.	PUNCT
bam-4803	440	1	j	j	PROPN
bam-4803	440	2	mol	mol	ADP
bam-4803	440	3	biol	biol	PROPN
bam-4803	440	4	2004;336:155	2004;336:155	NUM
bam-4803	440	5	-	-	SYM
bam-4803	440	6	64	64	NUM
bam-4803	440	7	.	.	PUNCT
bam-4803	441	1	87	87	NUM
bam-4803	441	2	.	.	PUNCT
bam-4803	442	1	serysheva	serysheva	PROPN
bam-4803	442	2	ii	ii	PROPN
bam-4803	442	3	,	,	PUNCT
bam-4803	442	4	ludtke	ludtke	PROPN
bam-4803	442	5	sj	sj	PROPN
bam-4803	442	6	,	,	PUNCT
bam-4803	442	7	baker	baker	PROPN
bam-4803	442	8	mr	mr	PROPN
bam-4803	442	9	,	,	PUNCT
bam-4803	442	10	et	et	PROPN
bam-4803	442	11	al	al	PROPN
bam-4803	442	12	.	.	PROPN
bam-4803	442	13	structure	structure	NOUN
bam-4803	442	14	of	of	ADP
bam-4803	442	15	the	the	DET
bam-4803	442	16	voltage	voltage	NOUN
bam-4803	442	17	-	-	PUNCT
bam-4803	442	18	gated	gate	VERB
bam-4803	442	19	l	l	NOUN
bam-4803	442	20	-	-	NOUN
bam-4803	442	21	type	type	NOUN
bam-4803	442	22	ca2	ca2	PROPN
bam-4803	442	23	+	+	NOUN
bam-4803	442	24	channel	channel	NOUN
bam-4803	442	25	by	by	ADP
bam-4803	442	26	electron	electron	NOUN
bam-4803	442	27	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	442	28	.	.	PUNCT
bam-4803	443	1	proc	proc	PROPN
bam-4803	443	2	natl	natl	PROPN
bam-4803	443	3	acad	acad	PROPN
bam-4803	443	4	sci	sci	PROPN
bam-4803	443	5	u	u	PROPN
bam-4803	443	6	s	s	PROPN
bam-4803	443	7	a	a	DET
bam-4803	443	8	2002;99:10370	2002;99:10370	NUM
bam-4803	443	9	-	-	SYM
bam-4803	443	10	5	5	NUM
bam-4803	443	11	.	.	NUM
bam-4803	443	12	88	88	NUM
bam-4803	443	13	.	.	PUNCT
bam-4803	444	1	wolf	wolf	PROPN
bam-4803	444	2	m	m	PROPN
bam-4803	444	3	,	,	PUNCT
bam-4803	444	4	eberhart	eberhart	NOUN
bam-4803	444	5	a	a	X
bam-4803	444	6	,	,	PUNCT
bam-4803	444	7	glossmann	glossmann	ADJ
bam-4803	444	8	h	h	NOUN
bam-4803	444	9	,	,	PUNCT
bam-4803	444	10	et	et	PROPN
bam-4803	444	11	al	al	PROPN
bam-4803	444	12	.	.	PUNCT
bam-4803	444	13	visualization	visualization	NOUN
bam-4803	444	14	of	of	ADP
bam-4803	444	15	the	the	DET
bam-4803	444	16	domain	domain	NOUN
bam-4803	444	17	structure	structure	NOUN
bam-4803	444	18	of	of	ADP
bam-4803	444	19	an	an	DET
bam-4803	444	20	l	l	NOUN
bam-4803	444	21	-	-	PUNCT
bam-4803	444	22	type	type	NOUN
bam-4803	444	23	ca	ca	NOUN
bam-4803	444	24	2	2	NUM
bam-4803	444	25	+	+	NOUN
bam-4803	444	26	channel	channel	NOUN
bam-4803	444	27	using	use	VERB
bam-4803	444	28	electron	electron	NOUN
bam-4803	444	29	cryo	cryo	NOUN
bam-4803	444	30	-	-	PUNCT
bam-4803	444	31	microscopy	microscopy	NOUN
bam-4803	444	32	.	.	PUNCT
bam-4803	445	1	j	j	PROPN
bam-4803	445	2	mol	mol	ADP
bam-4803	445	3	biol	biol	PROPN
bam-4803	445	4	2003;332:171	2003;332:171	NUM
bam-4803	445	5	-	-	SYM
bam-4803	445	6	82	82	NUM
bam-4803	445	7	.	.	NOUN
bam-4803	445	8	89	89	NUM
bam-4803	445	9	.	.	PUNCT
bam-4803	445	10	mio	mio	PROPN
bam-4803	445	11	k	k	PROPN
bam-4803	445	12	,	,	PUNCT
bam-4803	445	13	ogura	ogura	PROPN
bam-4803	445	14	t	t	PROPN
bam-4803	445	15	,	,	PUNCT
bam-4803	445	16	kiyonaka	kiyonaka	PROPN
bam-4803	445	17	s	s	PROPN
bam-4803	445	18	,	,	PUNCT
bam-4803	445	19	et	et	PROPN
bam-4803	445	20	al	al	PROPN
bam-4803	445	21	.	.	PUNCT
bam-4803	446	1	the	the	DET
bam-4803	446	2	trpc3	trpc3	PROPN
bam-4803	446	3	channel	channel	NOUN
bam-4803	446	4	has	have	VERB
bam-4803	446	5	a	a	DET
bam-4803	446	6	large	large	ADJ
bam-4803	446	7	internal	internal	ADJ
bam-4803	446	8	chamber	chamber	NOUN
bam-4803	446	9	surrounded	surround	VERB
bam-4803	446	10	by	by	ADP
bam-4803	446	11	signal	signal	NOUN
bam-4803	446	12	sensing	sense	VERB
bam-4803	446	13	antennas	antenna	NOUN
bam-4803	446	14	.	.	PUNCT
bam-4803	447	1	j	j	PROPN
bam-4803	447	2	mol	mol	ADP
bam-4803	447	3	biol	biol	PROPN
bam-4803	447	4	2007;367:373	2007;367:373	NUM
bam-4803	447	5	-	-	SYM
bam-4803	447	6	83	83	NUM
bam-4803	447	7	.	.	PUNCT
bam-4803	447	8	90	90	NUM
bam-4803	447	9	.	.	PUNCT
bam-4803	448	1	shigematsu	shigematsu	PROPN
bam-4803	448	2	h	h	PROPN
bam-4803	448	3	,	,	PUNCT
bam-4803	448	4	sokabe	sokabe	PROPN
bam-4803	448	5	t	t	PROPN
bam-4803	448	6	,	,	PUNCT
bam-4803	448	7	danev	danev	NOUN
bam-4803	448	8	r	r	NOUN
bam-4803	448	9	,	,	PUNCT
bam-4803	448	10	et	et	PROPN
bam-4803	448	11	al	al	PROPN
bam-4803	448	12	.	.	PUNCT
bam-4803	449	1	a	a	DET
bam-4803	449	2	3.5	3.5	NUM
bam-4803	449	3	nm	nm	NOUN
bam-4803	449	4	structure	structure	NOUN
bam-4803	449	5	of	of	ADP
bam-4803	449	6	rat	rat	NOUN
bam-4803	449	7	trpv4	trpv4	PROPN
bam-4803	449	8	cation	cation	NOUN
bam-4803	449	9	channel	channel	NOUN
bam-4803	449	10	revealed	reveal	VERB
bam-4803	449	11	by	by	ADP
bam-4803	449	12	zernike	zernike	NOUN
bam-4803	449	13	phase	phase	NOUN
bam-4803	449	14	-	-	PUNCT
bam-4803	449	15	contrast	contrast	NOUN
bam-4803	449	16	cryoelectron	cryoelectron	NOUN
bam-4803	449	17	microscopy	microscopy	NOUN
bam-4803	449	18	.	.	PUNCT
bam-4803	450	1	j	j	PROPN
bam-4803	450	2	biol	biol	PROPN
bam-4803	450	3	chem	chem	NOUN
bam-4803	450	4	2009;285:11210	2009;285:11210	NUM
bam-4803	450	5	-	-	SYM
bam-4803	450	6	8	8	NUM
bam-4803	450	7	.	.	NOUN
bam-4803	450	8	91	91	NUM
bam-4803	450	9	.	.	PUNCT
bam-4803	451	1	moiseenkova	moiseenkova	NOUN
bam-4803	451	2	-	-	PUNCT
bam-4803	451	3	bell	bell	NOUN
bam-4803	451	4	vy	vy	NOUN
bam-4803	451	5	,	,	PUNCT
bam-4803	451	6	stanciu	stanciu	PROPN
bam-4803	451	7	la	la	PROPN
bam-4803	451	8	,	,	PUNCT
bam-4803	451	9	et	et	PROPN
bam-4803	451	10	al	al	PROPN
bam-4803	451	11	.	.	PROPN
bam-4803	451	12	structure	structure	NOUN
bam-4803	451	13	of	of	ADP
bam-4803	451	14	trpv1	trpv1	NOUN
bam-4803	451	15	channel	channel	NOUN
bam-4803	451	16	revealed	reveal	VERB
bam-4803	451	17	by	by	ADP
bam-4803	451	18	electron	electron	NOUN
bam-4803	451	19	cryomicroscopy	cryomicroscopy	NOUN
bam-4803	451	20	.	.	PUNCT
bam-4803	452	1	proc	proc	PROPN
bam-4803	452	2	natl	natl	PROPN
bam-4803	452	3	acad	acad	PROPN
bam-4803	452	4	sci	sci	PROPN
bam-4803	452	5	u	u	PROPN
bam-4803	452	6	s	s	PROPN
bam-4803	452	7	a	a	DET
bam-4803	452	8	2008;105:7451	2008;105:7451	NUM
bam-4803	452	9	-	-	PUNCT
bam-4803	452	10	5	5	NUM
bam-4803	452	11	.	.	NOUN
bam-4803	452	12	92	92	NUM
bam-4803	452	13	.	.	PUNCT
bam-4803	453	1	huynh	huynh	PROPN
bam-4803	453	2	kw	kw	PROPN
bam-4803	453	3	,	,	PUNCT
bam-4803	453	4	cohen	cohen	PROPN
bam-4803	453	5	mr	mr	PROPN
bam-4803	453	6	,	,	PUNCT
bam-4803	453	7	chakrapani	chakrapani	PROPN
bam-4803	453	8	s	s	PROPN
bam-4803	453	9	,	,	PUNCT
bam-4803	453	10	et	et	PROPN
bam-4803	453	11	al	al	PROPN
bam-4803	453	12	.	.	PROPN
bam-4803	453	13	structural	structural	ADJ
bam-4803	453	14	insight	insight	NOUN
bam-4803	453	15	into	into	ADP
bam-4803	453	16	the	the	DET
bam-4803	453	17	assembly	assembly	NOUN
bam-4803	453	18	of	of	ADP
bam-4803	453	19	trpv	trpv	NOUN
bam-4803	453	20	channels	channel	NOUN
bam-4803	453	21	.	.	PUNCT
bam-4803	454	1	structure	structure	NOUN
bam-4803	454	2	2014;22:260	2014;22:260	NUM
bam-4803	454	3	-	-	SYM
bam-4803	454	4	8	8	NUM
bam-4803	454	5	.	.	PUNCT
bam-4803	454	6	93	93	NUM
bam-4803	454	7	.	.	PUNCT
bam-4803	455	1	cvetkov	cvetkov	PROPN
bam-4803	455	2	tl	tl	PROPN
bam-4803	455	3	,	,	PUNCT
bam-4803	455	4	huynh	huynh	PROPN
bam-4803	455	5	kw	kw	PROPN
bam-4803	455	6	,	,	PUNCT
bam-4803	455	7	cohen	cohen	PROPN
bam-4803	455	8	mr	mr	PROPN
bam-4803	455	9	,	,	PUNCT
bam-4803	455	10	moiseenkova	moiseenkova	NOUN
bam-4803	455	11	-	-	PUNCT
bam-4803	455	12	bell	bell	NOUN
bam-4803	455	13	vy	vy	NOUN
bam-4803	455	14	.	.	PUNCT
bam-4803	456	1	molecular	molecular	ADJ
bam-4803	456	2	architecture	architecture	NOUN
bam-4803	456	3	and	and	CCONJ
bam-4803	456	4	subunit	subunit	NOUN
bam-4803	456	5	organization	organization	NOUN
bam-4803	456	6	of	of	ADP
bam-4803	456	7	trpa1	trpa1	PROPN
bam-4803	456	8	ion	ion	NOUN
bam-4803	456	9	channel	channel	NOUN
bam-4803	456	10	revealed	reveal	VERB
bam-4803	456	11	by	by	ADP
bam-4803	456	12	electron	electron	NOUN
bam-4803	456	13	microscopy	microscopy	NOUN
bam-4803	456	14	.	.	PUNCT
bam-4803	457	1	j	j	PROPN
bam-4803	457	2	biol	biol	PROPN
bam-4803	457	3	chem	chem	NOUN
bam-4803	457	4	2011;286:38168	2011;286:38168	NUM
bam-4803	457	5	-	-	SYM
bam-4803	457	6	76	76	NUM
bam-4803	457	7	.	.	PUNCT
bam-4803	458	1	94	94	NUM
bam-4803	458	2	.	.	PUNCT
bam-4803	459	1	jiang	jiang	PROPN
bam-4803	459	2	qx	qx	PROPN
bam-4803	459	3	,	,	PUNCT
bam-4803	459	4	wang	wang	PROPN
bam-4803	459	5	dn	dn	PROPN
bam-4803	459	6	,	,	PUNCT
bam-4803	459	7	mackinnon	mackinnon	PROPN
bam-4803	459	8	r.	r.	PROPN
bam-4803	459	9	electron	electron	PROPN
bam-4803	459	10	microscopic	microscopic	ADJ
bam-4803	459	11	analysis	analysis	NOUN
bam-4803	459	12	of	of	ADP
bam-4803	459	13	kvap	kvap	NOUN
bam-4803	459	14	voltage	voltage	NOUN
bam-4803	459	15	-	-	PUNCT
bam-4803	459	16	dependent	dependent	ADJ
bam-4803	459	17	k	k	NOUN
bam-4803	460	1	+	+	CCONJ
bam-4803	460	2	channels	channel	NOUN
bam-4803	460	3	in	in	ADP
bam-4803	460	4	an	an	DET
bam-4803	460	5	open	open	ADJ
bam-4803	460	6	conformation	conformation	NOUN
bam-4803	460	7	.	.	PUNCT
bam-4803	461	1	nature	nature	NOUN
bam-4803	461	2	2004;430:806	2004;430:806	PROPN
bam-4803	461	3	-	-	SYM
bam-4803	461	4	10	10	NUM
bam-4803	461	5	.	.	PUNCT
bam-4803	461	6	95	95	NUM
bam-4803	461	7	.	.	PUNCT
bam-4803	462	1	shigematsu	shigematsu	PROPN
bam-4803	462	2	h	h	PROPN
bam-4803	462	3	,	,	PUNCT
bam-4803	462	4	iida	iida	PROPN
bam-4803	462	5	k	k	PROPN
bam-4803	462	6	,	,	PUNCT
bam-4803	462	7	nakano	nakano	PROPN
bam-4803	462	8	m	m	PROPN
bam-4803	462	9	,	,	PUNCT
bam-4803	462	10	et	et	PROPN
bam-4803	462	11	al	al	PROPN
bam-4803	462	12	.	.	PROPN
bam-4803	462	13	structural	structural	ADJ
bam-4803	462	14	characterization	characterization	NOUN
bam-4803	462	15	of	of	ADP
bam-4803	462	16	the	the	DET
bam-4803	462	17	mechanosensitive	mechanosensitive	ADJ
bam-4803	462	18	channel	channel	NOUN
bam-4803	462	19	candidate	candidate	NOUN
bam-4803	462	20	mca2	mca2	NOUN
bam-4803	462	21	from	from	ADP
bam-4803	462	22	arabidopsis	arabidopsis	NOUN
bam-4803	462	23	thaliana	thaliana	NOUN
bam-4803	462	24	.	.	PUNCT
bam-4803	463	1	plos	plos	PROPN
bam-4803	463	2	one	one	NUM
bam-4803	463	3	2014;9	2014;9	NUM
bam-4803	463	4	:	:	PUNCT
bam-4803	463	5	e87724	e87724	NOUN
bam-4803	463	6	.	.	PUNCT
bam-4803	464	1	96	96	NUM
bam-4803	464	2	.	.	PUNCT
bam-4803	465	1	lau	lau	PROPN
bam-4803	465	2	wc	wc	PROPN
bam-4803	465	3	,	,	PUNCT
bam-4803	465	4	rubinstein	rubinstein	PROPN
bam-4803	465	5	jl	jl	PROPN
bam-4803	465	6	.	.	PUNCT
bam-4803	465	7	subnanometre	subnanometre	NOUN
bam-4803	465	8	-	-	PUNCT
bam-4803	465	9	resolution	resolution	NOUN
bam-4803	465	10	structure	structure	NOUN
bam-4803	465	11	of	of	ADP
bam-4803	465	12	the	the	DET
bam-4803	465	13	intact	intact	ADJ
bam-4803	465	14	thermus	thermus	NOUN
bam-4803	465	15	thermophilus	thermophilus	NOUN
bam-4803	465	16	h	h	PROPN
bam-4803	465	17	+	+	CCONJ
bam-4803	465	18	driven	drive	VERB
bam-4803	465	19	atp	atp	NOUN
bam-4803	465	20	synthase	synthase	NOUN
bam-4803	465	21	.	.	PUNCT
bam-4803	466	1	nature	nature	NOUN
bam-4803	466	2	2012;481(7380):214	2012;481(7380):214	NUM
bam-4803	466	3	-	-	SYM
bam-4803	466	4	8	8	NUM
bam-4803	466	5	.	.	X
bam-4803	466	6	97	97	NUM
bam-4803	466	7	.	.	PUNCT
bam-4803	467	1	benlekbir	benlekbir	PROPN
bam-4803	467	2	s	s	PROPN
bam-4803	467	3	,	,	PUNCT
bam-4803	467	4	bueler	bueler	PROPN
bam-4803	467	5	sa	sa	PROPN
bam-4803	467	6	,	,	PUNCT
bam-4803	467	7	rubinstein	rubinstein	PROPN
bam-4803	467	8	jl	jl	PROPN
bam-4803	467	9	.	.	PUNCT
bam-4803	468	1	structure	structure	NOUN
bam-4803	468	2	of	of	ADP
bam-4803	468	3	the	the	DET
bam-4803	468	4	vacuolar	vacuolar	ADJ
bam-4803	468	5	-	-	PUNCT
bam-4803	468	6	type	type	NOUN
bam-4803	468	7	atpase	atpase	NOUN
bam-4803	468	8	from	from	ADP
bam-4803	468	9	saccharomyces	saccharomyce	NOUN
bam-4803	468	10	cerevisiae	cerevisiae	NOUN
bam-4803	468	11	at	at	ADP
bam-4803	468	12	11å	11å	NOUN
bam-4803	468	13	resolution	resolution	NOUN
bam-4803	468	14	.	.	PUNCT
bam-4803	469	1	nat	nat	PROPN
bam-4803	469	2	struct	struct	NOUN
bam-4803	469	3	mol	mol	ADP
bam-4803	469	4	biol	biol	PROPN
bam-4803	469	5	2012;19:1356	2012;19:1356	NOUN
bam-4803	469	6	-	-	SYM
bam-4803	469	7	62	62	NUM
bam-4803	469	8	.	.	PUNCT
bam-4803	470	1	98	98	NUM
bam-4803	470	2	.	.	PUNCT
bam-4803	471	1	lau	lau	PROPN
bam-4803	471	2	k	k	PROPN
bam-4803	471	3	,	,	PUNCT
bam-4803	471	4	van	van	PROPN
bam-4803	471	5	petegen	petegen	PROPN
bam-4803	471	6	f.	f.	PROPN
bam-4803	471	7	crystal	crystal	PROPN
bam-4803	471	8	structures	structure	NOUN
bam-4803	471	9	of	of	ADP
bam-4803	471	10	wild	wild	ADJ
bam-4803	471	11	type	type	NOUN
bam-4803	471	12	and	and	CCONJ
bam-4803	471	13	disease	disease	NOUN
bam-4803	471	14	mutant	mutant	NOUN
bam-4803	471	15	forms	form	NOUN
bam-4803	471	16	of	of	ADP
bam-4803	471	17	the	the	DET
bam-4803	471	18	ryanodine	ryanodine	NOUN
bam-4803	471	19	receptor	receptor	NOUN
bam-4803	471	20	spry2	spry2	ADJ
bam-4803	471	21	domain	domain	NOUN
bam-4803	471	22	.	.	PUNCT
bam-4803	472	1	nature	nature	NOUN
bam-4803	472	2	comm	comm	NOUN
bam-4803	472	3	2014;5:5397	2014;5:5397	NOUN
bam-4803	472	4	.	.	PUNCT
bam-4803	473	1	99	99	NUM
bam-4803	473	2	.	.	PUNCT
bam-4803	473	3	xu	xu	PROPN
bam-4803	474	1	l	l	PROPN
bam-4803	474	2	,	,	PUNCT
bam-4803	474	3	wang	wang	PROPN
bam-4803	474	4	y	y	PROPN
bam-4803	474	5	,	,	PUNCT
bam-4803	474	6	gillespie	gillespie	PROPN
bam-4803	474	7	d	d	PROPN
bam-4803	474	8	,	,	PUNCT
bam-4803	474	9	meissner	meissner	PROPN
bam-4803	474	10	g.	g.	PROPN
bam-4803	474	11	two	two	NUM
bam-4803	474	12	rings	ring	NOUN
bam-4803	474	13	of	of	ADP
bam-4803	474	14	negative	negative	ADJ
bam-4803	474	15	charges	charge	NOUN
bam-4803	474	16	in	in	ADP
bam-4803	474	17	the	the	DET
bam-4803	474	18	cytosolic	cytosolic	ADJ
bam-4803	474	19	vestibule	vestibule	NOUN
bam-4803	474	20	of	of	ADP
bam-4803	474	21	type-1	type-1	PROPN
bam-4803	474	22	ryanodine	ryanodine	VERB
bam-4803	474	23	receptor	receptor	NOUN
bam-4803	474	24	modulate	modulate	VERB
bam-4803	474	25	ion	ion	NOUN
bam-4803	474	26	fluxes	flux	NOUN
bam-4803	474	27	.	.	PUNCT
bam-4803	475	1	biophys	biophy	NOUN
bam-4803	475	2	j	j	PROPN
bam-4803	475	3	2006;90:443	2006;90:443	PROPN
bam-4803	475	4	-	-	SYM
bam-4803	475	5	53	53	NUM
bam-4803	475	6	.	.	NOUN
bam-4803	475	7	100	100	NUM
bam-4803	475	8	.	.	PUNCT
bam-4803	476	1	ramachandran	ramachandran	PROPN
bam-4803	476	2	s	s	PROPN
bam-4803	476	3	,	,	PUNCT
bam-4803	476	4	chakraborty	chakraborty	PROPN
bam-4803	476	5	a	a	PROPN
bam-4803	476	6	,	,	PUNCT
bam-4803	476	7	xu	xu	PROPN
bam-4803	476	8	l	l	PROPN
bam-4803	476	9	,	,	PUNCT
bam-4803	476	10	et	et	PROPN
bam-4803	476	11	al	al	PROPN
bam-4803	476	12	..	..	PUNCT
bam-4803	476	13	structural	structural	ADJ
bam-4803	476	14	determinants	determinant	NOUN
bam-4803	476	15	of	of	ADP
bam-4803	476	16	skeletal	skeletal	ADJ
bam-4803	476	17	muscle	muscle	NOUN
bam-4803	476	18	ryanodine	ryanodine	NOUN
bam-4803	476	19	receptor	receptor	NOUN
bam-4803	476	20	.	.	PUNCT
bam-4803	477	1	j	j	PROPN
bam-4803	477	2	biol	biol	PROPN
bam-4803	477	3	chem	chem	NOUN
bam-4803	477	4	2013;288:615462	2013;288:615462	NUM
bam-4803	477	5	.	.	PUNCT