id	sid	tid	token	lemma	pos
bam-4840	1	1	bam	bam	VERB
bam-4840	1	2	12	12	NUM
bam-4840	1	3	(	(	PUNCT
bam-4840	1	4	1	1	NUM
bam-4840	1	5	)	)	PUNCT
bam-4840	1	6	2002	2002	NUM
bam-4840	1	7	3d	3d	NUM
bam-4840	1	8	structure	structure	NOUN
bam-4840	1	9	of	of	ADP
bam-4840	1	10	muscle	muscle	NOUN
bam-4840	1	11	dihydropyridine	dihydropyridine	NOUN
bam-4840	1	12	receptor	receptor	PROPN
bam-4840	1	13	eur	eur	PROPN
bam-4840	1	14	j	j	PROPN
bam-4840	1	15	transl	transl	PROPN
bam-4840	1	16	myol	myol	PROPN
bam-4840	1	17	basic	basic	ADJ
bam-4840	1	18	appl	appl	NOUN
bam-4840	1	19	myol	myol	NOUN
bam-4840	1	20	2015	2015	NUM
bam-4840	1	21	;	;	PUNCT
bam-4840	1	22	25	25	NUM
bam-4840	1	23	(	(	PUNCT
bam-4840	1	24	1	1	NUM
bam-4840	1	25	):	):	PUNCT
bam-4840	1	26	27	27	NUM
bam-4840	1	27	-	-	SYM
bam-4840	1	28	33	33	NUM
bam-4840	1	29	27	27	NUM
bam-4840	1	30	3d	3d	NOUN
bam-4840	1	31	structure	structure	NOUN
bam-4840	1	32	of	of	ADP
bam-4840	1	33	the	the	DET
bam-4840	1	34	dihydropyridine	dihydropyridine	NOUN
bam-4840	1	35	receptor	receptor	NOUN
bam-4840	1	36	of	of	ADP
bam-4840	1	37	skeletal	skeletal	ADJ
bam-4840	1	38	muscle	muscle	NOUN
bam-4840	1	39	montserrat	montserrat	PROPN
bam-4840	1	40	samsó	samsó	PROPN
bam-4840	1	41	department	department	PROPN
bam-4840	1	42	of	of	ADP
bam-4840	1	43	physiology	physiology	NOUN
bam-4840	1	44	and	and	CCONJ
bam-4840	1	45	biophysics	biophysic	NOUN
bam-4840	1	46	,	,	PUNCT
bam-4840	1	47	virginia	virginia	PROPN
bam-4840	1	48	commonwealth	commonwealth	PROPN
bam-4840	1	49	university	university	PROPN
bam-4840	1	50	,	,	PUNCT
bam-4840	1	51	richmond	richmond	PROPN
bam-4840	1	52	,	,	PUNCT
bam-4840	1	53	va	va	PROPN
bam-4840	1	54	,	,	PUNCT
bam-4840	1	55	usa	usa	PROPN
bam-4840	1	56	abstract	abstract	ADJ
bam-4840	1	57	excitation	excitation	NOUN
bam-4840	1	58	contraction	contraction	NOUN
bam-4840	1	59	coupling	coupling	NOUN
bam-4840	1	60	,	,	PUNCT
bam-4840	1	61	the	the	DET
bam-4840	1	62	rapid	rapid	ADJ
bam-4840	1	63	and	and	CCONJ
bam-4840	1	64	massive	massive	ADJ
bam-4840	1	65	ca	ca	NOUN
bam-4840	1	66	2	2	NUM
bam-4840	1	67	+	+	NOUN
bam-4840	1	68	release	release	NOUN
bam-4840	1	69	under	under	ADP
bam-4840	1	70	control	control	NOUN
bam-4840	1	71	of	of	ADP
bam-4840	1	72	an	an	DET
bam-4840	1	73	action	action	NOUN
bam-4840	1	74	potential	potential	NOUN
bam-4840	1	75	that	that	PRON
bam-4840	1	76	triggers	trigger	VERB
bam-4840	1	77	muscle	muscle	NOUN
bam-4840	1	78	contraction	contraction	NOUN
bam-4840	1	79	,	,	PUNCT
bam-4840	1	80	takes	take	VERB
bam-4840	1	81	places	place	NOUN
bam-4840	1	82	at	at	ADP
bam-4840	1	83	specialized	specialized	ADJ
bam-4840	1	84	regions	region	NOUN
bam-4840	1	85	of	of	ADP
bam-4840	1	86	the	the	DET
bam-4840	1	87	cell	cell	NOUN
bam-4840	1	88	called	call	VERB
bam-4840	1	89	triad	triad	NOUN
bam-4840	1	90	junctions	junction	NOUN
bam-4840	1	91	.	.	PUNCT
bam-4840	2	1	there	there	ADV
bam-4840	2	2	,	,	PUNCT
bam-4840	2	3	a	a	DET
bam-4840	2	4	highly	highly	ADV
bam-4840	2	5	ordered	order	VERB
bam-4840	2	6	supramolecular	supramolecular	ADJ
bam-4840	2	7	complex	complex	NOUN
bam-4840	2	8	between	between	ADP
bam-4840	2	9	the	the	DET
bam-4840	2	10	dihydropyridine	dihydropyridine	NOUN
bam-4840	2	11	receptor	receptor	NOUN
bam-4840	2	12	(	(	PUNCT
bam-4840	2	13	dhpr	dhpr	NOUN
bam-4840	2	14	)	)	PUNCT
bam-4840	2	15	and	and	CCONJ
bam-4840	2	16	the	the	DET
bam-4840	2	17	ryanodine	ryanodine	NOUN
bam-4840	2	18	receptor	receptor	NOUN
bam-4840	2	19	(	(	PUNCT
bam-4840	2	20	ryr1	ryr1	NOUN
bam-4840	2	21	)	)	PUNCT
bam-4840	2	22	mediates	mediate	VERB
bam-4840	2	23	the	the	DET
bam-4840	2	24	quasi‐instantaneous	quasi‐instantaneous	PROPN
bam-4840	2	25	conversion	conversion	NOUN
bam-4840	2	26	from	from	ADP
bam-4840	2	27	t‐tubule	t‐tubule	ADJ
bam-4840	2	28	depolarization	depolarization	NOUN
bam-4840	2	29	into	into	ADP
bam-4840	2	30	ca	ca	NOUN
bam-4840	2	31	2	2	NUM
bam-4840	2	32	+	+	NOUN
bam-4840	2	33	release	release	NOUN
bam-4840	2	34	from	from	ADP
bam-4840	2	35	the	the	DET
bam-4840	2	36	sarcoplasmic	sarcoplasmic	NOUN
bam-4840	2	37	reticulum	reticulum	NOUN
bam-4840	2	38	(	(	PUNCT
bam-4840	2	39	sr	sr	PROPN
bam-4840	2	40	)	)	PUNCT
bam-4840	2	41	.	.	PUNCT
bam-4840	3	1	the	the	DET
bam-4840	3	2	dhpr	dhpr	NOUN
bam-4840	3	3	has	have	VERB
bam-4840	3	4	several	several	ADJ
bam-4840	3	5	key	key	ADJ
bam-4840	3	6	modules	module	NOUN
bam-4840	3	7	required	require	VERB
bam-4840	3	8	for	for	ADP
bam-4840	3	9	ec	ec	PROPN
bam-4840	3	10	coupling	coupling	NOUN
bam-4840	3	11	:	:	PUNCT
bam-4840	3	12	the	the	DET
bam-4840	3	13	voltage	voltage	NOUN
bam-4840	3	14	sensors	sensor	NOUN
bam-4840	3	15	and	and	CCONJ
bam-4840	3	16	ii‐iii	ii‐iii	PROPN
bam-4840	3	17	loop	loop	NOUN
bam-4840	3	18	in	in	ADP
bam-4840	3	19	the	the	DET
bam-4840	3	20	alpha1s	alpha1s	ADJ
bam-4840	3	21	subunit	subunit	NOUN
bam-4840	3	22	,	,	PUNCT
bam-4840	3	23	and	and	CCONJ
bam-4840	3	24	the	the	DET
bam-4840	3	25	beta	beta	ADJ
bam-4840	3	26	subunit	subunit	NOUN
bam-4840	3	27	.	.	PUNCT
bam-4840	4	1	to	to	PART
bam-4840	4	2	gain	gain	VERB
bam-4840	4	3	insight	insight	NOUN
bam-4840	4	4	into	into	ADP
bam-4840	4	5	their	their	PRON
bam-4840	4	6	molecular	molecular	ADJ
bam-4840	4	7	organization	organization	NOUN
bam-4840	4	8	,	,	PUNCT
bam-4840	4	9	this	this	DET
bam-4840	4	10	review	review	NOUN
bam-4840	4	11	examines	examine	VERB
bam-4840	4	12	the	the	DET
bam-4840	4	13	most	most	ADV
bam-4840	4	14	updated	update	VERB
bam-4840	4	15	3d	3d	NUM
bam-4840	4	16	structure	structure	NOUN
bam-4840	4	17	of	of	ADP
bam-4840	4	18	the	the	DET
bam-4840	4	19	dhpr	dhpr	NOUN
bam-4840	4	20	as	as	SCONJ
bam-4840	4	21	obtained	obtain	VERB
bam-4840	4	22	by	by	ADP
bam-4840	4	23	transmission	transmission	NOUN
bam-4840	4	24	electron	electron	NOUN
bam-4840	4	25	microscopy	microscopy	NOUN
bam-4840	4	26	and	and	CCONJ
bam-4840	4	27	image	image	NOUN
bam-4840	4	28	reconstruction	reconstruction	NOUN
bam-4840	4	29	.	.	PUNCT
bam-4840	5	1	although	although	SCONJ
bam-4840	5	2	structure	structure	NOUN
bam-4840	5	3	determination	determination	NOUN
bam-4840	5	4	of	of	ADP
bam-4840	5	5	a	a	DET
bam-4840	5	6	heteromeric	heteromeric	ADJ
bam-4840	5	7	membrane	membrane	NOUN
bam-4840	5	8	protein	protein	NOUN
bam-4840	5	9	such	such	ADJ
bam-4840	5	10	as	as	ADP
bam-4840	5	11	the	the	DET
bam-4840	5	12	dhpr	dhpr	NOUN
bam-4840	5	13	is	be	AUX
bam-4840	5	14	challenging	challenging	ADJ
bam-4840	5	15	,	,	PUNCT
bam-4840	5	16	novel	novel	ADJ
bam-4840	5	17	technical	technical	ADJ
bam-4840	5	18	advances	advance	NOUN
bam-4840	5	19	in	in	ADP
bam-4840	5	20	protein	protein	NOUN
bam-4840	5	21	expression	expression	NOUN
bam-4840	5	22	and	and	CCONJ
bam-4840	5	23	3d	3d	NUM
bam-4840	5	24	labeling	labeling	NOUN
bam-4840	5	25	facilitated	facilitate	VERB
bam-4840	5	26	this	this	DET
bam-4840	5	27	task	task	NOUN
bam-4840	5	28	.	.	PUNCT
bam-4840	6	1	the	the	DET
bam-4840	6	2	3d	3d	PROPN
bam-4840	6	3	structure	structure	NOUN
bam-4840	6	4	of	of	ADP
bam-4840	6	5	the	the	DET
bam-4840	6	6	dhpr	dhpr	ADJ
bam-4840	6	7	complex	complex	ADJ
bam-4840	6	8	consists	consist	NOUN
bam-4840	6	9	of	of	ADP
bam-4840	6	10	a	a	DET
bam-4840	6	11	main	main	ADJ
bam-4840	6	12	body	body	NOUN
bam-4840	6	13	with	with	ADP
bam-4840	6	14	five	five	NUM
bam-4840	6	15	irregular	irregular	ADJ
bam-4840	6	16	corners	corner	NOUN
bam-4840	6	17	around	around	ADP
bam-4840	6	18	its	its	PRON
bam-4840	6	19	perimeter	perimeter	NOUN
bam-4840	6	20	encompassing	encompass	VERB
bam-4840	6	21	the	the	DET
bam-4840	6	22	transmembrane	transmembrane	ADJ
bam-4840	6	23	alpha	alpha	NOUN
bam-4840	6	24	1s	1s	NUM
bam-4840	6	25	subunit	subunit	NOUN
bam-4840	6	26	besides	besides	SCONJ
bam-4840	6	27	the	the	DET
bam-4840	6	28	intracellular	intracellular	ADJ
bam-4840	6	29	beta	beta	ADJ
bam-4840	6	30	subunit	subunit	NOUN
bam-4840	6	31	,	,	PUNCT
bam-4840	6	32	an	an	DET
bam-4840	6	33	extended	extended	ADJ
bam-4840	6	34	extracellular	extracellular	ADJ
bam-4840	6	35	alpha	alpha	NOUN
bam-4840	6	36	2	2	NUM
bam-4840	6	37	subunit	subunit	NOUN
bam-4840	6	38	,	,	PUNCT
bam-4840	6	39	and	and	CCONJ
bam-4840	6	40	a	a	DET
bam-4840	6	41	bulky	bulky	ADJ
bam-4840	6	42	intracellular	intracellular	ADJ
bam-4840	6	43	ii‐iii	ii‐iii	PROPN
bam-4840	6	44	loop	loop	NOUN
bam-4840	6	45	.	.	PUNCT
bam-4840	7	1	the	the	DET
bam-4840	7	2	structural	structural	ADJ
bam-4840	7	3	definition	definition	NOUN
bam-4840	7	4	attained	attain	VERB
bam-4840	7	5	at	at	ADP
bam-4840	7	6	19	19	NUM
bam-4840	7	7	å	å	PROPN
bam-4840	7	8	resolution	resolution	NOUN
bam-4840	7	9	enabled	enable	VERB
bam-4840	7	10	docking	docking	NOUN
bam-4840	7	11	of	of	ADP
bam-4840	7	12	the	the	DET
bam-4840	7	13	atomic	atomic	ADJ
bam-4840	7	14	coordinates	coordinate	NOUN
bam-4840	7	15	of	of	ADP
bam-4840	7	16	structural	structural	ADJ
bam-4840	7	17	homologs	homolog	NOUN
bam-4840	7	18	of	of	ADP
bam-4840	7	19	the	the	DET
bam-4840	7	20	alpha1s	alpha1s	ADJ
bam-4840	7	21	and	and	CCONJ
bam-4840	7	22	beta	beta	ADJ
bam-4840	7	23	subunits	subunit	NOUN
bam-4840	7	24	.	.	PUNCT
bam-4840	8	1	these	these	DET
bam-4840	8	2	structural	structural	ADJ
bam-4840	8	3	features	feature	NOUN
bam-4840	8	4	,	,	PUNCT
bam-4840	8	5	together	together	ADV
bam-4840	8	6	with	with	ADP
bam-4840	8	7	their	their	PRON
bam-4840	8	8	relative	relative	ADJ
bam-4840	8	9	location	location	NOUN
bam-4840	8	10	with	with	ADP
bam-4840	8	11	respect	respect	NOUN
bam-4840	8	12	to	to	ADP
bam-4840	8	13	the	the	DET
bam-4840	8	14	ryr1	ryr1	NOUN
bam-4840	8	15	,	,	PUNCT
bam-4840	8	16	are	be	AUX
bam-4840	8	17	discussed	discuss	VERB
bam-4840	8	18	in	in	ADP
bam-4840	8	19	the	the	DET
bam-4840	8	20	context	context	NOUN
bam-4840	8	21	of	of	ADP
bam-4840	8	22	the	the	DET
bam-4840	8	23	functional	functional	ADJ
bam-4840	8	24	data	datum	NOUN
bam-4840	8	25	.	.	PUNCT
bam-4840	9	1	key	key	ADJ
bam-4840	9	2	words	word	NOUN
bam-4840	9	3	:	:	PUNCT
bam-4840	9	4	dihydropyridine	dihydropyridine	NOUN
bam-4840	9	5	receptor	receptor	NOUN
bam-4840	9	6	,	,	PUNCT
bam-4840	9	7	excitation‐contraction	excitation‐contraction	NOUN
bam-4840	9	8	coupling	coupling	NOUN
bam-4840	9	9	,	,	PUNCT
bam-4840	9	10	transmission	transmission	NOUN
bam-4840	9	11	electron	electron	NOUN
bam-4840	9	12	microscopy	microscopy	NOUN
bam-4840	9	13	,	,	PUNCT
bam-4840	9	14	3d	3d	PROPN
bam-4840	9	15	reconstruction	reconstruction	NOUN
bam-4840	9	16	eur	eur	PROPN
bam-4840	9	17	j	j	PROPN
bam-4840	9	18	tranls	tranls	NOUN
bam-4840	9	19	myol	myol	NOUN
bam-4840	9	20	basic	basic	ADJ
bam-4840	9	21	appl	appl	NOUN
bam-4840	9	22	myol	myol	NOUN
bam-4840	9	23	2015	2015	NUM
bam-4840	9	24	;	;	PUNCT
bam-4840	9	25	25	25	NUM
bam-4840	9	26	(	(	PUNCT
bam-4840	9	27	1	1	NUM
bam-4840	9	28	):	):	PUNCT
bam-4840	9	29	27	27	NUM
bam-4840	9	30	-	-	SYM
bam-4840	9	31	33	33	NUM
bam-4840	9	32	the	the	DET
bam-4840	9	33	process	process	NOUN
bam-4840	9	34	by	by	ADP
bam-4840	9	35	which	which	PRON
bam-4840	9	36	an	an	DET
bam-4840	9	37	action	action	NOUN
bam-4840	9	38	potential	potential	NOUN
bam-4840	9	39	propagating	propagate	VERB
bam-4840	9	40	through	through	ADP
bam-4840	9	41	the	the	DET
bam-4840	9	42	muscle	muscle	NOUN
bam-4840	9	43	plasma	plasma	NOUN
bam-4840	9	44	membrane	membrane	NOUN
bam-4840	9	45	results	result	NOUN
bam-4840	9	46	into	into	ADP
bam-4840	9	47	ca	ca	NOUN
bam-4840	9	48	2	2	NUM
bam-4840	9	49	+	+	NOUN
bam-4840	9	50	release	release	NOUN
bam-4840	9	51	from	from	ADP
bam-4840	9	52	the	the	DET
bam-4840	9	53	sarcoplasmic	sarcoplasmic	NOUN
bam-4840	9	54	reticulum	reticulum	NOUN
bam-4840	9	55	(	(	PUNCT
bam-4840	9	56	sr	sr	PROPN
bam-4840	9	57	)	)	PUNCT
bam-4840	9	58	and	and	CCONJ
bam-4840	9	59	subsequent	subsequent	ADJ
bam-4840	9	60	muscle	muscle	NOUN
bam-4840	9	61	contraction	contraction	NOUN
bam-4840	9	62	is	be	AUX
bam-4840	9	63	called	call	VERB
bam-4840	9	64	excitation‐contraction	excitation‐contraction	NOUN
bam-4840	9	65	(	(	PUNCT
bam-4840	9	66	ec	ec	PROPN
bam-4840	9	67	)	)	PUNCT
bam-4840	9	68	coupling	coupling	NOUN
bam-4840	9	69	.	.	PUNCT
bam-4840	10	1	in	in	ADP
bam-4840	10	2	skeletal	skeletal	ADJ
bam-4840	10	3	muscle	muscle	NOUN
bam-4840	10	4	of	of	ADP
bam-4840	10	5	vertebrates	vertebrate	NOUN
bam-4840	10	6	this	this	DET
bam-4840	10	7	process	process	NOUN
bam-4840	10	8	takes	take	VERB
bam-4840	10	9	place	place	NOUN
bam-4840	10	10	in	in	ADP
bam-4840	10	11	the	the	DET
bam-4840	10	12	triad	triad	ADJ
bam-4840	10	13	junction	junction	NOUN
bam-4840	10	14	,	,	PUNCT
bam-4840	10	15	where	where	SCONJ
bam-4840	10	16	the	the	DET
bam-4840	10	17	transverse‐tubule	transverse‐tubule	NOUN
bam-4840	10	18	(	(	PUNCT
bam-4840	10	19	tt	tt	PROPN
bam-4840	10	20	)	)	PUNCT
bam-4840	10	21	extensions	extension	NOUN
bam-4840	10	22	of	of	ADP
bam-4840	10	23	the	the	DET
bam-4840	10	24	plasma	plasma	NOUN
bam-4840	10	25	membrane	membrane	NOUN
bam-4840	10	26	,	,	PUNCT
bam-4840	10	27	orthogonal	orthogonal	ADJ
bam-4840	10	28	to	to	ADP
bam-4840	10	29	the	the	DET
bam-4840	10	30	main	main	ADJ
bam-4840	10	31	axis	axis	NOUN
bam-4840	10	32	of	of	ADP
bam-4840	10	33	the	the	DET
bam-4840	10	34	muscle	muscle	NOUN
bam-4840	10	35	fiber	fiber	NOUN
bam-4840	10	36	,	,	PUNCT
bam-4840	10	37	run	run	VERB
bam-4840	10	38	adjacent	adjacent	ADJ
bam-4840	10	39	to	to	ADP
bam-4840	10	40	the	the	DET
bam-4840	10	41	terminal	terminal	ADJ
bam-4840	10	42	cisternae	cisternae	NOUN
bam-4840	10	43	of	of	ADP
bam-4840	10	44	the	the	DET
bam-4840	10	45	sr	sr	PROPN
bam-4840	10	46	.	.	PROPN
bam-4840	11	1	1	1	NUM
bam-4840	12	1	the	the	DET
bam-4840	12	2	close	close	ADJ
bam-4840	12	3	apposition	apposition	NOUN
bam-4840	12	4	of	of	ADP
bam-4840	12	5	the	the	DET
bam-4840	12	6	tt	tt	PROPN
bam-4840	12	7	and	and	CCONJ
bam-4840	12	8	sr	sr	PROPN
bam-4840	12	9	membranes	membrane	NOUN
bam-4840	12	10	brings	bring	VERB
bam-4840	12	11	together	together	ADV
bam-4840	12	12	the	the	DET
bam-4840	12	13	dihydropyridine	dihydropyridine	NOUN
bam-4840	12	14	receptor	receptor	NOUN
bam-4840	12	15	(	(	PUNCT
bam-4840	12	16	dhpr	dhpr	NOUN
bam-4840	12	17	)	)	PUNCT
bam-4840	12	18	and	and	CCONJ
bam-4840	12	19	the	the	DET
bam-4840	12	20	ryanodine	ryanodine	NOUN
bam-4840	12	21	receptor	receptor	NOUN
bam-4840	12	22	(	(	PUNCT
bam-4840	12	23	ryr1	ryr1	NOUN
bam-4840	12	24	)	)	PUNCT
bam-4840	12	25	,	,	PUNCT
bam-4840	12	26	two	two	NUM
bam-4840	12	27	calcium	calcium	NOUN
bam-4840	12	28	channels	channel	NOUN
bam-4840	12	29	residing	reside	VERB
bam-4840	12	30	respectively	respectively	ADV
bam-4840	12	31	in	in	ADP
bam-4840	12	32	each	each	PRON
bam-4840	12	33	of	of	ADP
bam-4840	12	34	these	these	DET
bam-4840	12	35	two	two	NUM
bam-4840	12	36	membrane	membrane	NOUN
bam-4840	12	37	systems	system	NOUN
bam-4840	12	38	.	.	PUNCT
bam-4840	13	1	upon	upon	SCONJ
bam-4840	13	2	depolarization	depolarization	NOUN
bam-4840	13	3	of	of	ADP
bam-4840	13	4	the	the	DET
bam-4840	13	5	plasma	plasma	NOUN
bam-4840	13	6	membrane	membrane	NOUN
bam-4840	13	7	and	and	CCONJ
bam-4840	13	8	tts	tts	PROPN
bam-4840	13	9	,	,	PUNCT
bam-4840	13	10	the	the	DET
bam-4840	13	11	dhprs	dhprs	NOUN
bam-4840	13	12	,	,	PUNCT
bam-4840	13	13	which	which	PRON
bam-4840	13	14	sense	sense	VERB
bam-4840	13	15	the	the	DET
bam-4840	13	16	voltage	voltage	NOUN
bam-4840	13	17	and	and	CCONJ
bam-4840	13	18	are	be	AUX
bam-4840	13	19	conformationally	conformationally	ADV
bam-4840	13	20	coupled	couple	VERB
bam-4840	13	21	to	to	ADP
bam-4840	13	22	ryr1s	ryr1s	VERB
bam-4840	13	23	,	,	PUNCT
bam-4840	13	24	induce	induce	VERB
bam-4840	13	25	the	the	DET
bam-4840	13	26	ryr1s	ryr1s	NOUN
bam-4840	13	27	to	to	PART
bam-4840	13	28	open	open	VERB
bam-4840	13	29	.	.	PUNCT
bam-4840	14	1	this	this	DET
bam-4840	14	2	opening	opening	NOUN
bam-4840	14	3	results	result	NOUN
bam-4840	14	4	in	in	ADP
bam-4840	14	5	a	a	DET
bam-4840	14	6	massive	massive	ADJ
bam-4840	14	7	release	release	NOUN
bam-4840	14	8	of	of	ADP
bam-4840	14	9	ca	ca	NOUN
bam-4840	14	10	2	2	NUM
bam-4840	14	11	+	+	NUM
bam-4840	14	12	from	from	ADP
bam-4840	14	13	the	the	DET
bam-4840	14	14	sr	sr	PROPN
bam-4840	14	15	and	and	CCONJ
bam-4840	14	16	the	the	DET
bam-4840	14	17	sudden	sudden	ADJ
bam-4840	14	18	raise	raise	NOUN
bam-4840	14	19	of	of	ADP
bam-4840	14	20	intracellular	intracellular	NOUN
bam-4840	14	21	ca	ca	AUX
bam-4840	14	22	2	2	NUM
bam-4840	14	23	+	+	NUM
bam-4840	14	24	triggers	trigger	VERB
bam-4840	14	25	contraction	contraction	NOUN
bam-4840	14	26	of	of	ADP
bam-4840	14	27	the	the	DET
bam-4840	14	28	muscle	muscle	NOUN
bam-4840	14	29	fibers	fiber	NOUN
bam-4840	14	30	.	.	PUNCT
bam-4840	15	1	2	2	NUM
bam-4840	15	2	dhpr	dhpr	ADJ
bam-4840	15	3	controls	control	NOUN
bam-4840	15	4	ryr1	ryr1	NOUN
bam-4840	15	5	not	not	PART
bam-4840	15	6	only	only	ADV
bam-4840	15	7	during	during	ADP
bam-4840	15	8	activation	activation	NOUN
bam-4840	15	9	(	(	PUNCT
bam-4840	15	10	ec	ec	PROPN
bam-4840	15	11	coupling	coupling	NOUN
bam-4840	15	12	)	)	PUNCT
bam-4840	15	13	but	but	CCONJ
bam-4840	15	14	also	also	ADV
bam-4840	15	15	at	at	ADP
bam-4840	15	16	rest	rest	NOUN
bam-4840	15	17	,	,	PUNCT
bam-4840	15	18	as	as	ADP
bam-4840	15	19	lack	lack	NOUN
bam-4840	15	20	of	of	ADP
bam-4840	15	21	dhpr	dhpr	ADJ
bam-4840	15	22	results	result	NOUN
bam-4840	15	23	in	in	ADP
bam-4840	15	24	elevated	elevated	ADJ
bam-4840	15	25	resting	rest	VERB
bam-4840	15	26	cytoplasmic	cytoplasmic	ADJ
bam-4840	15	27	ca	ca	NOUN
bam-4840	15	28	2	2	NUM
bam-4840	15	29	+	+	NOUN
bam-4840	15	30	,	,	PUNCT
bam-4840	15	31	3	3	NUM
bam-4840	15	32	and	and	CCONJ
bam-4840	15	33	mutations	mutation	NOUN
bam-4840	15	34	in	in	ADP
bam-4840	15	35	dhpr	dhpr	ADJ
bam-4840	15	36	result	result	NOUN
bam-4840	15	37	in	in	ADP
bam-4840	15	38	the	the	DET
bam-4840	15	39	malignant	malignant	ADJ
bam-4840	15	40	hyperthermia	hyperthermia	NOUN
bam-4840	15	41	syndrome	syndrome	PROPN
bam-4840	15	42	4­6	4­6	PROPN
bam-4840	15	43	that	that	PRON
bam-4840	15	44	has	have	AUX
bam-4840	15	45	been	be	AUX
bam-4840	15	46	associated	associate	VERB
bam-4840	15	47	with	with	ADP
bam-4840	15	48	dysregulation	dysregulation	NOUN
bam-4840	15	49	of	of	ADP
bam-4840	15	50	resting	rest	VERB
bam-4840	15	51	cytoplasmic	cytoplasmic	ADJ
bam-4840	15	52	ca	ca	NOUN
bam-4840	15	53	2	2	NUM
bam-4840	15	54	+	+	NUM
bam-4840	15	55	levels	level	NOUN
bam-4840	15	56	.	.	PUNCT
bam-4840	16	1	7,8	7,8	NUM
bam-4840	16	2	role	role	NOUN
bam-4840	16	3	of	of	ADP
bam-4840	16	4	the	the	DET
bam-4840	16	5	dihydripyridine	dihydripyridine	NOUN
bam-4840	16	6	receptor	receptor	NOUN
bam-4840	16	7	in	in	ADP
bam-4840	16	8	excitation	excitation	NOUN
bam-4840	16	9	-	-	PUNCT
bam-4840	16	10	contraction	contraction	NOUN
bam-4840	16	11	coupling	coupling	NOUN
bam-4840	16	12	of	of	ADP
bam-4840	16	13	skeletal	skeletal	ADJ
bam-4840	16	14	muscle	muscle	NOUN
bam-4840	16	15	ec	ec	PROPN
bam-4840	16	16	coupling	coupling	NOUN
bam-4840	16	17	relies	rely	VERB
bam-4840	16	18	on	on	ADP
bam-4840	16	19	a	a	DET
bam-4840	16	20	supramolecular	supramolecular	ADJ
bam-4840	16	21	complex	complex	NOUN
bam-4840	16	22	between	between	ADP
bam-4840	16	23	dhpr	dhpr	NOUN
bam-4840	16	24	,	,	PUNCT
bam-4840	16	25	which	which	PRON
bam-4840	16	26	is	be	AUX
bam-4840	16	27	the	the	DET
bam-4840	16	28	tt	tt	PROPN
bam-4840	16	29	voltage	voltage	NOUN
bam-4840	16	30	sensor	sensor	NOUN
bam-4840	16	31	,	,	PUNCT
bam-4840	16	32	and	and	CCONJ
bam-4840	16	33	the	the	DET
bam-4840	16	34	ryr1	ryr1	NOUN
bam-4840	16	35	,	,	PUNCT
bam-4840	16	36	which	which	PRON
bam-4840	16	37	is	be	AUX
bam-4840	16	38	the	the	DET
bam-4840	16	39	sr	sr	PROPN
bam-4840	16	40	ca	ca	PROPN
bam-4840	16	41	2	2	NUM
bam-4840	16	42	+	+	NOUN
bam-4840	16	43	release	release	NOUN
bam-4840	16	44	channel	channel	NOUN
bam-4840	16	45	.	.	PUNCT
bam-4840	17	1	the	the	DET
bam-4840	17	2	distinctive	distinctive	ADJ
bam-4840	17	3	spatial	spatial	ADJ
bam-4840	17	4	relationship	relationship	NOUN
bam-4840	17	5	between	between	ADP
bam-4840	17	6	these	these	DET
bam-4840	17	7	two	two	NUM
bam-4840	17	8	proteins	protein	NOUN
bam-4840	17	9	was	be	AUX
bam-4840	17	10	revealed	reveal	VERB
bam-4840	17	11	using	use	VERB
bam-4840	17	12	freeze	freeze	NOUN
bam-4840	17	13	fracture	fracture	NOUN
bam-4840	17	14	–	–	PUNCT
bam-4840	17	15	shadowing	shadow	VERB
bam-4840	17	16	electron	electron	NOUN
bam-4840	17	17	microscopy	microscopy	NOUN
bam-4840	17	18	.	.	PUNCT
bam-4840	18	1	on	on	ADP
bam-4840	18	2	the	the	DET
bam-4840	18	3	sr	sr	PROPN
bam-4840	18	4	terminal	terminal	PROPN
bam-4840	18	5	cisternae	cisternae	PROPN
bam-4840	18	6	side	side	NOUN
bam-4840	18	7	of	of	ADP
bam-4840	18	8	the	the	DET
bam-4840	18	9	triad	triad	ADJ
bam-4840	18	10	junction	junction	NOUN
bam-4840	18	11	,	,	PUNCT
bam-4840	18	12	large	large	ADJ
bam-4840	18	13	proteins	protein	NOUN
bam-4840	18	14	named	name	VERB
bam-4840	18	15	“	"	PUNCT
bam-4840	18	16	feet	foot	NOUN
bam-4840	18	17	”	"	PUNCT
bam-4840	18	18	have	have	AUX
bam-4840	18	19	been	be	AUX
bam-4840	18	20	identified	identify	VERB
bam-4840	18	21	as	as	ADP
bam-4840	18	22	ryr1	ryr1	NOUN
bam-4840	18	23	.	.	PUNCT
bam-4840	19	1	these	these	DET
bam-4840	19	2	form	form	NOUN
bam-4840	19	3	ordered	order	VERB
bam-4840	19	4	2d	2d	NUM
bam-4840	19	5	arrays	array	VERB
bam-4840	19	6	,	,	PUNCT
bam-4840	19	7	whereby	whereby	SCONJ
bam-4840	19	8	ryr1s	ryr1s	NOUN
bam-4840	19	9	contact	contact	NOUN
bam-4840	19	10	each	each	DET
bam-4840	19	11	other	other	ADJ
bam-4840	19	12	through	through	ADP
bam-4840	19	13	their	their	PRON
bam-4840	19	14	corners	corner	NOUN
bam-4840	19	15	forming	form	VERB
bam-4840	19	16	two	two	NUM
bam-4840	19	17	or	or	CCONJ
bam-4840	19	18	three	three	NUM
bam-4840	19	19	rows	row	NOUN
bam-4840	19	20	along	along	ADP
bam-4840	19	21	the	the	DET
bam-4840	19	22	edge	edge	NOUN
bam-4840	19	23	of	of	ADP
bam-4840	19	24	the	the	DET
bam-4840	19	25	terminal	terminal	ADJ
bam-4840	19	26	cisternae	cisternae	NOUN
bam-4840	19	27	.	.	PUNCT
bam-4840	20	1	on	on	ADP
bam-4840	20	2	the	the	DET
bam-4840	20	3	tt	tt	PROPN
bam-4840	20	4	side	side	NOUN
bam-4840	20	5	,	,	PUNCT
bam-4840	20	6	groups	group	NOUN
bam-4840	20	7	of	of	ADP
bam-4840	20	8	four	four	NUM
bam-4840	20	9	particles	particle	NOUN
bam-4840	20	10	(	(	PUNCT
bam-4840	20	11	tetrads	tetrad	NOUN
bam-4840	20	12	)	)	PUNCT
bam-4840	20	13	,	,	PUNCT
bam-4840	20	14	identified	identify	VERB
bam-4840	20	15	as	as	ADP
bam-4840	20	16	3d	3d	NUM
bam-4840	20	17	structure	structure	NOUN
bam-4840	20	18	of	of	ADP
bam-4840	20	19	muscle	muscle	NOUN
bam-4840	20	20	dihydropyridine	dihydropyridine	NOUN
bam-4840	20	21	receptor	receptor	PROPN
bam-4840	20	22	eur	eur	PROPN
bam-4840	20	23	j	j	PROPN
bam-4840	20	24	transl	transl	PROPN
bam-4840	20	25	myol	myol	PROPN
bam-4840	20	26	basic	basic	ADJ
bam-4840	20	27	appl	appl	NOUN
bam-4840	20	28	myol	myol	NOUN
bam-4840	20	29	2015	2015	NUM
bam-4840	20	30	;	;	PUNCT
bam-4840	20	31	25	25	NUM
bam-4840	20	32	(	(	PUNCT
bam-4840	20	33	1	1	NUM
bam-4840	20	34	):	):	PUNCT
bam-4840	20	35	27	27	NUM
bam-4840	20	36	-	-	SYM
bam-4840	20	37	33	33	NUM
bam-4840	20	38	28	28	NUM
bam-4840	20	39	four	four	NUM
bam-4840	20	40	dhprs	dhprs	NOUN
bam-4840	20	41	,	,	PUNCT
bam-4840	20	42	correlated	correlate	VERB
bam-4840	20	43	with	with	ADP
bam-4840	20	44	the	the	DET
bam-4840	20	45	disposition	disposition	NOUN
bam-4840	20	46	of	of	ADP
bam-4840	20	47	individual	individual	ADJ
bam-4840	20	48	ryr1	ryr1	NOUN
bam-4840	20	49	particles	particle	NOUN
bam-4840	20	50	on	on	ADP
bam-4840	20	51	the	the	DET
bam-4840	20	52	sr	sr	PROPN
bam-4840	20	53	.	.	PUNCT
bam-4840	21	1	tetrads	tetrad	NOUN
bam-4840	21	2	overlap	overlap	VERB
bam-4840	21	3	alternate	alternate	ADJ
bam-4840	21	4	ryr1s	ryr1s	PROPN
bam-4840	21	5	,	,	PUNCT
bam-4840	21	6	leaving	leave	VERB
bam-4840	21	7	an	an	DET
bam-4840	21	8	“	"	PUNCT
bam-4840	21	9	orphan	orphan	NOUN
bam-4840	21	10	”	"	PUNCT
bam-4840	21	11	ryr1	ryr1	NOUN
bam-4840	21	12	in	in	ADP
bam-4840	21	13	between	between	ADP
bam-4840	21	14	.	.	PUNCT
bam-4840	22	1	9	9	NUM
bam-4840	22	2	the	the	DET
bam-4840	22	3	tetrads	tetrad	NOUN
bam-4840	22	4	of	of	ADP
bam-4840	22	5	dhpr	dhpr	NOUN
bam-4840	22	6	are	be	AUX
bam-4840	22	7	formed	form	VERB
bam-4840	22	8	by	by	ADP
bam-4840	22	9	the	the	DET
bam-4840	22	10	specific	specific	ADJ
bam-4840	22	11	interaction	interaction	NOUN
bam-4840	22	12	between	between	ADP
bam-4840	22	13	each	each	DET
bam-4840	22	14	dhpr	dhpr	NOUN
bam-4840	22	15	and	and	CCONJ
bam-4840	22	16	each	each	PRON
bam-4840	22	17	of	of	ADP
bam-4840	22	18	the	the	DET
bam-4840	22	19	four	four	NUM
bam-4840	22	20	corners	corner	NOUN
bam-4840	22	21	of	of	ADP
bam-4840	22	22	the	the	DET
bam-4840	22	23	much	much	ADV
bam-4840	22	24	larger	large	ADJ
bam-4840	22	25	,	,	PUNCT
bam-4840	22	26	prism‐shaped	prism‐shaped	ADJ
bam-4840	22	27	homotetrameric	homotetrameric	ADJ
bam-4840	22	28	ryr1	ryr1	NOUN
bam-4840	22	29	,	,	PUNCT
bam-4840	22	30	and	and	CCONJ
bam-4840	22	31	do	do	AUX
bam-4840	22	32	not	not	PART
bam-4840	22	33	form	form	VERB
bam-4840	22	34	in	in	ADP
bam-4840	22	35	its	its	PRON
bam-4840	22	36	absence	absence	NOUN
bam-4840	22	37	.	.	PUNCT
bam-4840	23	1	10	10	NUM
bam-4840	23	2	further	further	ADJ
bam-4840	23	3	evidence	evidence	NOUN
bam-4840	23	4	of	of	ADP
bam-4840	23	5	the	the	DET
bam-4840	23	6	tight	tight	ADJ
bam-4840	23	7	interaction	interaction	NOUN
bam-4840	23	8	between	between	ADP
bam-4840	23	9	dhpr	dhpr	NOUN
bam-4840	23	10	and	and	CCONJ
bam-4840	23	11	ryr1	ryr1	NOUN
bam-4840	23	12	is	be	AUX
bam-4840	23	13	the	the	DET
bam-4840	23	14	change	change	NOUN
bam-4840	23	15	in	in	ADP
bam-4840	23	16	intra‐tetrad	intra‐tetrad	ADJ
bam-4840	23	17	distance	distance	NOUN
bam-4840	23	18	when	when	SCONJ
bam-4840	23	19	applying	apply	VERB
bam-4840	23	20	an	an	DET
bam-4840	23	21	effector	effector	NOUN
bam-4840	23	22	known	know	VERB
bam-4840	23	23	to	to	PART
bam-4840	23	24	change	change	VERB
bam-4840	23	25	the	the	DET
bam-4840	23	26	conformation	conformation	NOUN
bam-4840	23	27	of	of	ADP
bam-4840	23	28	ryr1	ryr1	NOUN
bam-4840	23	29	.	.	PUNCT
bam-4840	24	1	11	11	NUM
bam-4840	25	1	the	the	DET
bam-4840	25	2	skeletal	skeletal	ADJ
bam-4840	25	3	muscle	muscle	NOUN
bam-4840	25	4	dhpr	dhpr	NOUN
bam-4840	25	5	is	be	AUX
bam-4840	25	6	a	a	DET
bam-4840	25	7	heteropentamer	heteropentamer	NOUN
bam-4840	25	8	formed	form	VERB
bam-4840	25	9	by	by	ADP
bam-4840	25	10	the	the	DET
bam-4840	25	11	1s	1s	NOUN
bam-4840	25	12	or	or	CCONJ
bam-4840	25	13	cav1.1	cav1.1	NOUN
bam-4840	25	14	,	,	PUNCT
bam-4840	25	15	2‐1	2‐1	PROPN
bam-4840	25	16	,	,	PUNCT
bam-4840	25	17	1a	1a	NOUN
bam-4840	25	18	,	,	PUNCT
bam-4840	25	19	and	and	CCONJ
bam-4840	25	20	subunits	subunit	NOUN
bam-4840	25	21	.	.	PROPN
bam-4840	25	22	12	12	NUM
bam-4840	25	23	cav1.1	cav1.1	NOUN
bam-4840	25	24	,	,	PUNCT
bam-4840	25	25	an	an	DET
bam-4840	25	26	l‐type	l‐type	PUNCT
bam-4840	25	27	voltage‐activated	voltage‐activate	VERB
bam-4840	25	28	ca	ca	NOUN
bam-4840	25	29	2	2	NUM
bam-4840	25	30	+	+	NUM
bam-4840	25	31	channel	channel	NOUN
bam-4840	25	32	,	,	PUNCT
bam-4840	25	33	acts	act	VERB
bam-4840	25	34	as	as	ADP
bam-4840	25	35	the	the	DET
bam-4840	25	36	voltage	voltage	NOUN
bam-4840	25	37	sensor	sensor	NOUN
bam-4840	25	38	for	for	ADP
bam-4840	25	39	ec	ec	PROPN
bam-4840	25	40	coupling	coupling	NOUN
bam-4840	25	41	.	.	PUNCT
bam-4840	26	1	13,14	13,14	NUM
bam-4840	26	2	since	since	SCONJ
bam-4840	26	3	its	its	PRON
bam-4840	26	4	ca	ca	PROPN
bam-4840	26	5	2	2	NUM
bam-4840	26	6	+	+	NOUN
bam-4840	26	7	channel	channel	NOUN
bam-4840	26	8	activity	activity	NOUN
bam-4840	26	9	is	be	AUX
bam-4840	26	10	irrelevant	irrelevant	ADJ
bam-4840	26	11	in	in	ADP
bam-4840	26	12	the	the	DET
bam-4840	26	13	ec	ec	PROPN
bam-4840	26	14	coupling	couple	VERB
bam-4840	26	15	context	context	NOUN
bam-4840	26	16	,	,	PUNCT
bam-4840	26	17	15,16	15,16	NUM
bam-4840	26	18	much	much	ADJ
bam-4840	26	19	effort	effort	NOUN
bam-4840	26	20	has	have	AUX
bam-4840	26	21	been	be	AUX
bam-4840	26	22	dedicated	dedicate	VERB
bam-4840	26	23	to	to	PART
bam-4840	26	24	understand	understand	VERB
bam-4840	26	25	how	how	SCONJ
bam-4840	26	26	the	the	DET
bam-4840	26	27	dhpr	dhpr	ADJ
bam-4840	26	28	transmits	transmit	VERB
bam-4840	26	29	the	the	DET
bam-4840	26	30	voltage‐sensing	voltage‐sensing	NOUN
bam-4840	26	31	signal	signal	NOUN
bam-4840	26	32	induced	induce	VERB
bam-4840	26	33	by	by	ADP
bam-4840	26	34	membrane	membrane	NOUN
bam-4840	26	35	depolarization	depolarization	NOUN
bam-4840	26	36	to	to	ADP
bam-4840	26	37	the	the	DET
bam-4840	26	38	ryr1	ryr1	NOUN
bam-4840	26	39	.	.	PUNCT
bam-4840	27	1	the	the	DET
bam-4840	27	2	main	main	ADJ
bam-4840	27	3	candidates	candidate	NOUN
bam-4840	27	4	that	that	PRON
bam-4840	27	5	have	have	AUX
bam-4840	27	6	emerged	emerge	VERB
bam-4840	27	7	are	be	AUX
bam-4840	27	8	the	the	DET
bam-4840	27	9	ii‐iii	ii‐iii	PROPN
bam-4840	27	10	loop	loop	NOUN
bam-4840	27	11	of	of	ADP
bam-4840	27	12	1s	1	NOUN
bam-4840	27	13	and	and	CCONJ
bam-4840	27	14	the	the	DET
bam-4840	27	15	1a	1a	NOUN
bam-4840	27	16	subunit	subunit	NOUN
bam-4840	27	17	:	:	PUNCT
bam-4840	27	18	their	their	PRON
bam-4840	27	19	presence	presence	NOUN
bam-4840	27	20	is	be	AUX
bam-4840	27	21	essential	essential	ADJ
bam-4840	27	22	for	for	ADP
bam-4840	27	23	ec	ec	PROPN
bam-4840	27	24	coupling	couple	VERB
bam-4840	27	25	17	17	NUM
bam-4840	27	26	-	-	SYM
bam-4840	27	27	19	19	NUM
bam-4840	27	28	and	and	CCONJ
bam-4840	27	29	tetrad	tetrad	NOUN
bam-4840	27	30	formation	formation	NOUN
bam-4840	27	31	.	.	PUNCT
bam-4840	28	1	20,21	20,21	NUM
bam-4840	28	2	thus	thus	ADV
bam-4840	28	3	,	,	PUNCT
bam-4840	28	4	it	it	PRON
bam-4840	28	5	became	become	VERB
bam-4840	28	6	important	important	ADJ
bam-4840	28	7	to	to	PART
bam-4840	28	8	see	see	VERB
bam-4840	28	9	how	how	SCONJ
bam-4840	28	10	these	these	DET
bam-4840	28	11	two	two	NUM
bam-4840	28	12	entities	entity	NOUN
bam-4840	28	13	are	be	AUX
bam-4840	28	14	organized	organize	VERB
bam-4840	28	15	within	within	ADP
bam-4840	28	16	the	the	DET
bam-4840	28	17	dhpr	dhpr	ADJ
bam-4840	28	18	complex	complex	NOUN
bam-4840	28	19	and	and	CCONJ
bam-4840	28	20	how	how	SCONJ
bam-4840	28	21	is	be	AUX
bam-4840	28	22	their	their	PRON
bam-4840	28	23	spatial	spatial	ADJ
bam-4840	28	24	relationship	relationship	NOUN
bam-4840	28	25	with	with	ADP
bam-4840	28	26	respect	respect	NOUN
bam-4840	28	27	to	to	ADP
bam-4840	28	28	the	the	DET
bam-4840	28	29	ryr1	ryr1	NOUN
bam-4840	28	30	.	.	PUNCT
bam-4840	29	1	challenges	challenge	NOUN
bam-4840	29	2	in	in	ADP
bam-4840	29	3	the	the	DET
bam-4840	29	4	structural	structural	ADJ
bam-4840	29	5	determination	determination	NOUN
bam-4840	29	6	of	of	ADP
bam-4840	29	7	the	the	DET
bam-4840	29	8	dhpr	dhpr	NOUN
bam-4840	29	9	the	the	DET
bam-4840	29	10	dhpr	dhpr	NOUN
bam-4840	29	11	has	have	AUX
bam-4840	29	12	been	be	AUX
bam-4840	29	13	visualized	visualize	VERB
bam-4840	29	14	within	within	ADP
bam-4840	29	15	the	the	DET
bam-4840	29	16	context	context	NOUN
bam-4840	29	17	of	of	ADP
bam-4840	29	18	the	the	DET
bam-4840	29	19	muscle	muscle	NOUN
bam-4840	29	20	tissue	tissue	NOUN
bam-4840	29	21	by	by	ADP
bam-4840	29	22	freeze	freeze	NOUN
bam-4840	29	23	fracture	fracture	NOUN
bam-4840	29	24	followed	follow	VERB
bam-4840	29	25	by	by	ADP
bam-4840	29	26	rotary	rotary	NOUN
bam-4840	29	27	shadowing	shadowing	NOUN
bam-4840	29	28	as	as	SCONJ
bam-4840	29	29	described	describe	VERB
bam-4840	29	30	above	above	ADV
bam-4840	29	31	.	.	PUNCT
bam-4840	30	1	in	in	ADP
bam-4840	30	2	this	this	DET
bam-4840	30	3	technique	technique	NOUN
bam-4840	30	4	,	,	PUNCT
bam-4840	30	5	the	the	DET
bam-4840	30	6	frozen	frozen	ADJ
bam-4840	30	7	tissue	tissue	NOUN
bam-4840	30	8	is	be	AUX
bam-4840	30	9	fractured	fracture	VERB
bam-4840	30	10	through	through	ADP
bam-4840	30	11	the	the	DET
bam-4840	30	12	less	less	ADV
bam-4840	30	13	cohesive	cohesive	ADJ
bam-4840	30	14	membrane	membrane	NOUN
bam-4840	30	15	planes	plane	NOUN
bam-4840	30	16	,	,	PUNCT
bam-4840	30	17	exposing	expose	VERB
bam-4840	30	18	the	the	DET
bam-4840	30	19	protruding	protrude	VERB
bam-4840	30	20	regions	region	NOUN
bam-4840	30	21	of	of	ADP
bam-4840	30	22	membrane	membrane	NOUN
bam-4840	30	23	proteins	protein	NOUN
bam-4840	30	24	.	.	PUNCT
bam-4840	31	1	these	these	DET
bam-4840	31	2	protrusions	protrusion	NOUN
bam-4840	31	3	can	can	AUX
bam-4840	31	4	then	then	ADV
bam-4840	31	5	be	be	AUX
bam-4840	31	6	highlighted	highlight	VERB
bam-4840	31	7	by	by	ADP
bam-4840	31	8	heavy	heavy	ADJ
bam-4840	31	9	metal	metal	NOUN
bam-4840	31	10	directional	directional	ADJ
bam-4840	31	11	or	or	CCONJ
bam-4840	31	12	rotary	rotary	NOUN
bam-4840	31	13	shadowing	shadowing	NOUN
bam-4840	31	14	and	and	CCONJ
bam-4840	31	15	then	then	ADV
bam-4840	31	16	imaged	image	VERB
bam-4840	31	17	on	on	ADP
bam-4840	31	18	the	the	DET
bam-4840	31	19	transmission	transmission	NOUN
bam-4840	31	20	electron	electron	NOUN
bam-4840	31	21	microscope	microscope	NOUN
bam-4840	31	22	(	(	PUNCT
bam-4840	31	23	tem	tem	PROPN
bam-4840	31	24	)	)	PUNCT
bam-4840	31	25	.	.	PUNCT
bam-4840	32	1	9	9	NUM
bam-4840	32	2	the	the	DET
bam-4840	32	3	particles	particle	NOUN
bam-4840	32	4	however	however	ADV
bam-4840	32	5	are	be	AUX
bam-4840	32	6	featureless	featureless	ADJ
bam-4840	32	7	and	and	CCONJ
bam-4840	32	8	the	the	DET
bam-4840	32	9	resolution	resolution	NOUN
bam-4840	32	10	of	of	ADP
bam-4840	32	11	this	this	DET
bam-4840	32	12	technique	technique	NOUN
bam-4840	32	13	is	be	AUX
bam-4840	32	14	limited	limit	VERB
bam-4840	32	15	by	by	ADP
bam-4840	32	16	the	the	DET
bam-4840	32	17	size	size	NOUN
bam-4840	32	18	of	of	ADP
bam-4840	32	19	the	the	DET
bam-4840	32	20	grain	grain	NOUN
bam-4840	32	21	of	of	ADP
bam-4840	32	22	evaporated	evaporate	VERB
bam-4840	32	23	heavy	heavy	ADJ
bam-4840	32	24	metal	metal	NOUN
bam-4840	32	25	,	,	PUNCT
bam-4840	32	26	to	to	ADP
bam-4840	32	27	around	around	ADP
bam-4840	32	28	50	50	NUM
bam-4840	32	29	å	å	NOUN
bam-4840	32	30	.	.	PUNCT
bam-4840	33	1	additionally	additionally	ADV
bam-4840	33	2	,	,	PUNCT
bam-4840	33	3	it	it	PRON
bam-4840	33	4	is	be	AUX
bam-4840	33	5	unclear	unclear	ADJ
bam-4840	33	6	which	which	DET
bam-4840	33	7	part	part	NOUN
bam-4840	33	8	of	of	ADP
bam-4840	33	9	the	the	DET
bam-4840	33	10	molecule	molecule	NOUN
bam-4840	33	11	is	be	AUX
bam-4840	33	12	represented	represent	VERB
bam-4840	33	13	by	by	ADP
bam-4840	33	14	the	the	DET
bam-4840	33	15	“	"	PUNCT
bam-4840	33	16	particle	particle	NOUN
bam-4840	33	17	”	"	PUNCT
bam-4840	33	18	since	since	SCONJ
bam-4840	33	19	the	the	DET
bam-4840	33	20	particle	particle	NOUN
bam-4840	33	21	size	size	NOUN
bam-4840	33	22	is	be	AUX
bam-4840	33	23	the	the	DET
bam-4840	33	24	same	same	ADJ
bam-4840	33	25	in	in	ADP
bam-4840	33	26	presence	presence	NOUN
bam-4840	33	27	and	and	CCONJ
bam-4840	33	28	absence	absence	NOUN
bam-4840	33	29	of	of	ADP
bam-4840	33	30	the	the	DET
bam-4840	33	31	2‐subunits	2‐subunit	NOUN
bam-4840	33	32	even	even	ADV
bam-4840	33	33	though	though	SCONJ
bam-4840	33	34	these	these	PRON
bam-4840	33	35	constitute	constitute	VERB
bam-4840	33	36	about	about	ADV
bam-4840	33	37	half	half	DET
bam-4840	33	38	the	the	DET
bam-4840	33	39	molecular	molecular	ADJ
bam-4840	33	40	weight	weight	NOUN
bam-4840	33	41	of	of	ADP
bam-4840	33	42	the	the	DET
bam-4840	33	43	whole	whole	ADJ
bam-4840	33	44	complex	complex	NOUN
bam-4840	33	45	.	.	PUNCT
bam-4840	34	1	22	22	NUM
bam-4840	34	2	an	an	DET
bam-4840	34	3	approach	approach	NOUN
bam-4840	34	4	to	to	PART
bam-4840	34	5	get	get	VERB
bam-4840	34	6	higher	high	ADJ
bam-4840	34	7	resolution	resolution	NOUN
bam-4840	34	8	,	,	PUNCT
bam-4840	34	9	at	at	ADP
bam-4840	34	10	the	the	DET
bam-4840	34	11	expense	expense	NOUN
bam-4840	34	12	of	of	ADP
bam-4840	34	13	losing	lose	VERB
bam-4840	34	14	the	the	DET
bam-4840	34	15	triad	triad	ADJ
bam-4840	34	16	context	context	NOUN
bam-4840	34	17	,	,	PUNCT
bam-4840	34	18	has	have	AUX
bam-4840	34	19	been	be	AUX
bam-4840	34	20	to	to	PART
bam-4840	34	21	extract	extract	VERB
bam-4840	34	22	the	the	DET
bam-4840	34	23	dhpr	dhpr	ADJ
bam-4840	34	24	complex	complex	NOUN
bam-4840	34	25	from	from	ADP
bam-4840	34	26	the	the	DET
bam-4840	34	27	membrane	membrane	NOUN
bam-4840	34	28	using	use	VERB
bam-4840	34	29	detergent	detergent	NOUN
bam-4840	34	30	,	,	PUNCT
bam-4840	34	31	and	and	CCONJ
bam-4840	34	32	then	then	ADV
bam-4840	34	33	to	to	PART
bam-4840	34	34	image	image	VERB
bam-4840	34	35	the	the	DET
bam-4840	34	36	solubilized	solubilize	VERB
bam-4840	34	37	protein	protein	NOUN
bam-4840	34	38	using	use	VERB
bam-4840	34	39	tem	tem	PROPN
bam-4840	34	40	and	and	CCONJ
bam-4840	34	41	single‐particle	single‐particle	PROPN
bam-4840	34	42	3d	3d	NUM
bam-4840	34	43	reconstruction	reconstruction	NOUN
bam-4840	34	44	.	.	PUNCT
bam-4840	35	1	purification	purification	NOUN
bam-4840	35	2	and	and	CCONJ
bam-4840	35	3	3d	3d	NUM
bam-4840	35	4	structural	structural	ADJ
bam-4840	35	5	determination	determination	NOUN
bam-4840	35	6	of	of	ADP
bam-4840	35	7	membrane	membrane	NOUN
bam-4840	35	8	proteins	protein	NOUN
bam-4840	35	9	has	have	VERB
bam-4840	35	10	many	many	ADJ
bam-4840	35	11	challenges	challenge	NOUN
bam-4840	35	12	when	when	SCONJ
bam-4840	35	13	compared	compare	VERB
bam-4840	35	14	to	to	ADP
bam-4840	35	15	soluble	soluble	ADJ
bam-4840	35	16	proteins	protein	NOUN
bam-4840	35	17	,	,	PUNCT
bam-4840	35	18	23	23	NUM
bam-4840	35	19	therefore	therefore	ADV
bam-4840	35	20	structures	structure	NOUN
bam-4840	35	21	of	of	ADP
bam-4840	35	22	membrane	membrane	NOUN
bam-4840	35	23	proteins	protein	NOUN
bam-4840	35	24	account	account	VERB
bam-4840	35	25	for	for	ADP
bam-4840	35	26	less	less	ADJ
bam-4840	35	27	than	than	ADP
bam-4840	35	28	2	2	NUM
bam-4840	35	29	%	%	NOUN
bam-4840	35	30	of	of	ADP
bam-4840	35	31	all	all	DET
bam-4840	35	32	protein	protein	NOUN
bam-4840	35	33	structures	structure	NOUN
bam-4840	35	34	available	available	ADJ
bam-4840	35	35	in	in	ADP
bam-4840	35	36	the	the	DET
bam-4840	35	37	3d	3d	NUM
bam-4840	35	38	structure	structure	NOUN
bam-4840	35	39	databases	database	NOUN
bam-4840	35	40	.	.	PUNCT
bam-4840	36	1	extraction	extraction	NOUN
bam-4840	36	2	of	of	ADP
bam-4840	36	3	the	the	DET
bam-4840	36	4	protein	protein	NOUN
bam-4840	36	5	from	from	ADP
bam-4840	36	6	the	the	DET
bam-4840	36	7	membrane	membrane	NOUN
bam-4840	36	8	needs	need	VERB
bam-4840	36	9	the	the	DET
bam-4840	36	10	right	right	ADJ
bam-4840	36	11	amount	amount	NOUN
bam-4840	36	12	of	of	ADP
bam-4840	36	13	detergent	detergent	NOUN
bam-4840	36	14	:	:	PUNCT
bam-4840	36	15	too	too	ADV
bam-4840	36	16	little	little	ADJ
bam-4840	36	17	detergent	detergent	NOUN
bam-4840	36	18	lowers	lower	VERB
bam-4840	36	19	the	the	DET
bam-4840	36	20	yield	yield	NOUN
bam-4840	36	21	of	of	ADP
bam-4840	36	22	protein	protein	NOUN
bam-4840	36	23	,	,	PUNCT
bam-4840	36	24	and	and	CCONJ
bam-4840	36	25	too	too	ADV
bam-4840	36	26	much	much	ADJ
bam-4840	36	27	detergent	detergent	NOUN
bam-4840	36	28	may	may	AUX
bam-4840	36	29	denature	denature	VERB
bam-4840	36	30	the	the	DET
bam-4840	36	31	protein	protein	NOUN
bam-4840	36	32	.	.	PUNCT
bam-4840	37	1	the	the	DET
bam-4840	37	2	choice	choice	NOUN
bam-4840	37	3	of	of	ADP
bam-4840	37	4	detergent	detergent	NOUN
bam-4840	37	5	is	be	AUX
bam-4840	37	6	also	also	ADV
bam-4840	37	7	important	important	ADJ
bam-4840	37	8	;	;	PUNCT
bam-4840	37	9	digitonin	digitonin	PROPN
bam-4840	37	10	has	have	AUX
bam-4840	37	11	been	be	AUX
bam-4840	37	12	the	the	DET
bam-4840	37	13	most	most	ADV
bam-4840	37	14	widely	widely	ADV
bam-4840	37	15	used	use	VERB
bam-4840	37	16	for	for	ADP
bam-4840	37	17	dhpr	dhpr	NOUN
bam-4840	37	18	.	.	PUNCT
bam-4840	38	1	after	after	ADP
bam-4840	38	2	extraction	extraction	NOUN
bam-4840	38	3	,	,	PUNCT
bam-4840	38	4	the	the	DET
bam-4840	38	5	dhpr	dhpr	NOUN
bam-4840	38	6	is	be	AUX
bam-4840	38	7	purified	purify	VERB
bam-4840	38	8	from	from	ADP
bam-4840	38	9	the	the	DET
bam-4840	38	10	other	other	ADJ
bam-4840	38	11	membrane	membrane	NOUN
bam-4840	38	12	proteins	protein	NOUN
bam-4840	38	13	using	use	VERB
bam-4840	38	14	chromatography	chromatography	NOUN
bam-4840	38	15	that	that	PRON
bam-4840	38	16	may	may	AUX
bam-4840	38	17	be	be	AUX
bam-4840	38	18	further	far	ADV
bam-4840	38	19	combined	combine	VERB
bam-4840	38	20	with	with	ADP
bam-4840	38	21	size	size	NOUN
bam-4840	38	22	separation	separation	NOUN
bam-4840	38	23	techniques	technique	NOUN
bam-4840	38	24	(	(	PUNCT
bam-4840	38	25	gel	gel	NOUN
bam-4840	38	26	filtration	filtration	NOUN
bam-4840	38	27	,	,	PUNCT
bam-4840	38	28	sucrose	sucrose	X
bam-4840	38	29	gradient	gradient	NOUN
bam-4840	38	30	)	)	PUNCT
bam-4840	38	31	.	.	PUNCT
bam-4840	39	1	since	since	SCONJ
bam-4840	39	2	dhpr	dhpr	NOUN
bam-4840	39	3	is	be	AUX
bam-4840	39	4	a	a	DET
bam-4840	39	5	heteropentamer	heteropentamer	ADJ
bam-4840	39	6	,	,	PUNCT
bam-4840	39	7	the	the	DET
bam-4840	39	8	purification	purification	NOUN
bam-4840	39	9	method	method	NOUN
bam-4840	39	10	also	also	ADV
bam-4840	39	11	has	have	VERB
bam-4840	39	12	to	to	PART
bam-4840	39	13	ensure	ensure	VERB
bam-4840	39	14	that	that	SCONJ
bam-4840	39	15	all	all	DET
bam-4840	39	16	subunits	subunit	NOUN
bam-4840	39	17	are	be	AUX
bam-4840	39	18	present	present	ADJ
bam-4840	39	19	at	at	ADP
bam-4840	39	20	the	the	DET
bam-4840	39	21	end	end	NOUN
bam-4840	39	22	of	of	ADP
bam-4840	39	23	the	the	DET
bam-4840	39	24	purification	purification	NOUN
bam-4840	39	25	process	process	NOUN
bam-4840	39	26	.	.	PUNCT
bam-4840	40	1	simultaneous	simultaneous	ADJ
bam-4840	40	2	heterologous	heterologous	ADJ
bam-4840	40	3	expression	expression	NOUN
bam-4840	40	4	of	of	ADP
bam-4840	40	5	all	all	DET
bam-4840	40	6	dhpr	dhpr	ADJ
bam-4840	40	7	subunits	subunit	NOUN
bam-4840	40	8	yielded	yield	VERB
bam-4840	40	9	functional	functional	ADJ
bam-4840	40	10	dhprs	dhprs	NOUN
bam-4840	40	11	in	in	ADP
bam-4840	40	12	cho	cho	PROPN
bam-4840	40	13	cells	cell	NOUN
bam-4840	40	14	,	,	PUNCT
bam-4840	40	15	24	24	NUM
bam-4840	40	16	however	however	ADV
bam-4840	40	17	producing	produce	VERB
bam-4840	40	18	sufficient	sufficient	ADJ
bam-4840	40	19	quantity	quantity	NOUN
bam-4840	40	20	for	for	ADP
bam-4840	40	21	protein	protein	NOUN
bam-4840	40	22	purification	purification	NOUN
bam-4840	40	23	could	could	AUX
bam-4840	40	24	prove	prove	VERB
bam-4840	40	25	difficult	difficult	ADJ
bam-4840	40	26	.	.	PUNCT
bam-4840	41	1	to	to	PART
bam-4840	41	2	overcome	overcome	VERB
bam-4840	41	3	many	many	ADJ
bam-4840	41	4	of	of	ADP
bam-4840	41	5	these	these	DET
bam-4840	41	6	challenges	challenge	NOUN
bam-4840	41	7	,	,	PUNCT
bam-4840	41	8	one	one	NUM
bam-4840	41	9	successful	successful	ADJ
bam-4840	41	10	approach	approach	NOUN
bam-4840	41	11	was	be	AUX
bam-4840	41	12	to	to	PART
bam-4840	41	13	genetically	genetically	ADV
bam-4840	41	14	engineer	engineer	VERB
bam-4840	41	15	one	one	NUM
bam-4840	41	16	of	of	ADP
bam-4840	41	17	the	the	DET
bam-4840	41	18	dhpr	dhpr	ADJ
bam-4840	41	19	subunits	subunit	NOUN
bam-4840	41	20	with	with	ADP
bam-4840	41	21	a	a	DET
bam-4840	41	22	tag	tag	NOUN
bam-4840	41	23	for	for	ADP
bam-4840	41	24	purification	purification	NOUN
bam-4840	41	25	,	,	PUNCT
bam-4840	41	26	and	and	CCONJ
bam-4840	41	27	a	a	DET
bam-4840	41	28	second	second	ADJ
bam-4840	41	29	tag	tag	NOUN
bam-4840	41	30	for	for	ADP
bam-4840	41	31	3d	3d	NOUN
bam-4840	41	32	identification	identification	NOUN
bam-4840	41	33	.	.	PUNCT
bam-4840	42	1	a	a	DET
bam-4840	42	2	transgenic	transgenic	NOUN
bam-4840	42	3	mouse	mouse	NOUN
bam-4840	42	4	expressing	express	VERB
bam-4840	42	5	this	this	DET
bam-4840	42	6	construct	construct	NOUN
bam-4840	42	7	was	be	AUX
bam-4840	42	8	then	then	ADV
bam-4840	42	9	generated	generate	VERB
bam-4840	42	10	for	for	ADP
bam-4840	42	11	protein	protein	NOUN
bam-4840	42	12	purification	purification	NOUN
bam-4840	42	13	.	.	PUNCT
bam-4840	43	1	25	25	NUM
bam-4840	44	1	for	for	ADP
bam-4840	44	2	3d	3d	NUM
bam-4840	44	3	structural	structural	ADJ
bam-4840	44	4	determination	determination	NOUN
bam-4840	44	5	the	the	DET
bam-4840	44	6	purified	purified	ADJ
bam-4840	44	7	dhpr	dhpr	NOUN
bam-4840	44	8	in	in	ADP
bam-4840	44	9	solution	solution	NOUN
bam-4840	44	10	is	be	AUX
bam-4840	44	11	then	then	ADV
bam-4840	44	12	prepared	prepared	ADJ
bam-4840	44	13	for	for	ADP
bam-4840	44	14	negative	negative	ADJ
bam-4840	44	15	staining	staining	NOUN
bam-4840	44	16	or	or	CCONJ
bam-4840	44	17	cryoem	cryoem	NOUN
bam-4840	44	18	,	,	PUNCT
bam-4840	44	19	and	and	CCONJ
bam-4840	44	20	imaged	image	VERB
bam-4840	44	21	on	on	ADP
bam-4840	44	22	the	the	DET
bam-4840	44	23	tem	tem	PROPN
bam-4840	44	24	.	.	PUNCT
bam-4840	45	1	negative	negative	ADJ
bam-4840	45	2	staining	stain	VERB
bam-4840	45	3	uses	use	VERB
bam-4840	45	4	heavy	heavy	ADJ
bam-4840	45	5	metals	metal	NOUN
bam-4840	45	6	to	to	PART
bam-4840	45	7	provide	provide	VERB
bam-4840	45	8	high	high	ADJ
bam-4840	45	9	contrast	contrast	NOUN
bam-4840	45	10	of	of	ADP
bam-4840	45	11	the	the	DET
bam-4840	45	12	dehydrated	dehydrate	VERB
bam-4840	45	13	protein	protein	NOUN
bam-4840	45	14	at	at	ADP
bam-4840	45	15	the	the	DET
bam-4840	45	16	expense	expense	NOUN
bam-4840	45	17	of	of	ADP
bam-4840	45	18	resolution	resolution	NOUN
bam-4840	45	19	(	(	PUNCT
bam-4840	45	20	up	up	ADP
bam-4840	45	21	to	to	PART
bam-4840	45	22	~20	~20	X
bam-4840	45	23	å	å	PROPN
bam-4840	45	24	resolution	resolution	NOUN
bam-4840	45	25	)	)	PUNCT
bam-4840	45	26	;	;	PUNCT
bam-4840	45	27	cryoem	cryoem	PROPN
bam-4840	45	28	has	have	VERB
bam-4840	45	29	less	less	ADJ
bam-4840	45	30	contrast	contrast	NOUN
bam-4840	45	31	but	but	CCONJ
bam-4840	45	32	records	record	VERB
bam-4840	45	33	images	image	NOUN
bam-4840	45	34	of	of	ADP
bam-4840	45	35	the	the	DET
bam-4840	45	36	protein	protein	NOUN
bam-4840	45	37	in	in	ADP
bam-4840	45	38	its	its	PRON
bam-4840	45	39	frozen	frozen	ADJ
bam-4840	45	40	hydrated	hydrated	ADJ
bam-4840	45	41	state	state	NOUN
bam-4840	45	42	and	and	CCONJ
bam-4840	45	43	has	have	VERB
bam-4840	45	44	the	the	DET
bam-4840	45	45	potential	potential	NOUN
bam-4840	45	46	for	for	ADP
bam-4840	45	47	higher	high	ADJ
bam-4840	45	48	resolution	resolution	NOUN
bam-4840	45	49	(	(	PUNCT
bam-4840	45	50	up	up	ADP
bam-4840	45	51	to	to	ADP
bam-4840	45	52	near	near	ADP
bam-4840	45	53	atomic	atomic	ADJ
bam-4840	45	54	resolution	resolution	NOUN
bam-4840	45	55	)	)	PUNCT
bam-4840	45	56	.	.	PUNCT
bam-4840	46	1	however	however	ADV
bam-4840	46	2	an	an	DET
bam-4840	46	3	additional	additional	ADJ
bam-4840	46	4	complication	complication	NOUN
bam-4840	46	5	for	for	ADP
bam-4840	46	6	membrane	membrane	ADJ
bam-4840	46	7	proteins	protein	NOUN
bam-4840	46	8	in	in	ADP
bam-4840	46	9	the	the	DET
bam-4840	46	10	case	case	NOUN
bam-4840	46	11	of	of	ADP
bam-4840	46	12	cryoem	cryoem	NOUN
bam-4840	46	13	is	be	AUX
bam-4840	46	14	the	the	DET
bam-4840	46	15	presence	presence	NOUN
bam-4840	46	16	of	of	ADP
bam-4840	46	17	detergent	detergent	NOUN
bam-4840	46	18	,	,	PUNCT
bam-4840	46	19	which	which	PRON
bam-4840	46	20	reduces	reduce	VERB
bam-4840	46	21	image	image	NOUN
bam-4840	46	22	contrast	contrast	NOUN
bam-4840	46	23	.	.	PUNCT
bam-4840	47	1	single‐particle	single‐particle	PROPN
bam-4840	47	2	image	image	NOUN
bam-4840	47	3	processing	processing	NOUN
bam-4840	47	4	uses	use	VERB
bam-4840	47	5	the	the	DET
bam-4840	47	6	different	different	ADJ
bam-4840	47	7	views	view	NOUN
bam-4840	47	8	of	of	ADP
bam-4840	47	9	the	the	DET
bam-4840	47	10	protein	protein	NOUN
bam-4840	47	11	to	to	PART
bam-4840	47	12	reconstruct	reconstruct	VERB
bam-4840	47	13	its	its	PRON
bam-4840	47	14	original	original	ADJ
bam-4840	47	15	shape	shape	NOUN
bam-4840	47	16	.	.	PUNCT
bam-4840	48	1	this	this	PRON
bam-4840	48	2	is	be	AUX
bam-4840	48	3	done	do	VERB
bam-4840	48	4	by	by	ADP
bam-4840	48	5	finding	find	VERB
bam-4840	48	6	the	the	DET
bam-4840	48	7	exact	exact	ADJ
bam-4840	48	8	orientation	orientation	NOUN
bam-4840	48	9	in	in	ADP
bam-4840	48	10	space	space	NOUN
bam-4840	48	11	of	of	ADP
bam-4840	48	12	each	each	DET
bam-4840	48	13	dhpr	dhpr	ADJ
bam-4840	48	14	“	"	PUNCT
bam-4840	48	15	particle	particle	NOUN
bam-4840	48	16	”	"	PUNCT
bam-4840	48	17	,	,	PUNCT
bam-4840	48	18	back	back	ADV
bam-4840	48	19	projecting	project	VERB
bam-4840	48	20	it	it	PRON
bam-4840	48	21	to	to	PART
bam-4840	48	22	obtain	obtain	VERB
bam-4840	48	23	its	its	PRON
bam-4840	48	24	3d	3d	ADJ
bam-4840	48	25	reconstruction	reconstruction	NOUN
bam-4840	48	26	using	use	VERB
bam-4840	48	27	algorithms	algorithm	NOUN
bam-4840	48	28	related	relate	VERB
bam-4840	48	29	to	to	ADP
bam-4840	48	30	these	these	PRON
bam-4840	48	31	used	use	VERB
bam-4840	48	32	in	in	ADP
bam-4840	48	33	tomography	tomography	NOUN
bam-4840	48	34	,	,	PUNCT
bam-4840	48	35	and	and	CCONJ
bam-4840	48	36	by	by	ADP
bam-4840	48	37	averaging	average	VERB
bam-4840	48	38	multiple	multiple	ADJ
bam-4840	48	39	(	(	PUNCT
bam-4840	48	40	thousands	thousand	NOUN
bam-4840	48	41	)	)	PUNCT
bam-4840	48	42	of	of	ADP
bam-4840	48	43	such	such	ADJ
bam-4840	48	44	particles	particle	NOUN
bam-4840	48	45	.	.	PUNCT
bam-4840	49	1	finding	find	VERB
bam-4840	49	2	the	the	DET
bam-4840	49	3	spatial	spatial	ADJ
bam-4840	49	4	orientation	orientation	NOUN
bam-4840	49	5	is	be	AUX
bam-4840	49	6	not	not	PART
bam-4840	49	7	trivial	trivial	ADJ
bam-4840	49	8	when	when	SCONJ
bam-4840	49	9	the	the	DET
bam-4840	49	10	3d	3d	NUM
bam-4840	49	11	structure	structure	NOUN
bam-4840	49	12	of	of	ADP
bam-4840	49	13	the	the	DET
bam-4840	49	14	protein	protein	NOUN
bam-4840	49	15	is	be	AUX
bam-4840	49	16	not	not	PART
bam-4840	49	17	known	know	VERB
bam-4840	49	18	;	;	PUNCT
bam-4840	49	19	specialized	specialized	ADJ
bam-4840	49	20	algorithms	algorithm	NOUN
bam-4840	49	21	and	and	CCONJ
bam-4840	49	22	software	software	NOUN
bam-4840	49	23	tackle	tackle	VERB
bam-4840	49	24	this	this	DET
bam-4840	49	25	problem	problem	NOUN
bam-4840	49	26	.	.	PUNCT
bam-4840	50	1	26,27	26,27	NUM
bam-4840	50	2	important	important	ADJ
bam-4840	50	3	factors	factor	NOUN
bam-4840	50	4	favoring	favor	VERB
bam-4840	50	5	3d	3d	NUM
bam-4840	50	6	structural	structural	ADJ
bam-4840	50	7	determination	determination	NOUN
bam-4840	50	8	are	be	AUX
bam-4840	50	9	a	a	DET
bam-4840	50	10	large	large	ADJ
bam-4840	50	11	size	size	NOUN
bam-4840	50	12	,	,	PUNCT
bam-4840	50	13	presence	presence	NOUN
bam-4840	50	14	of	of	ADP
bam-4840	50	15	distinctive	distinctive	ADJ
bam-4840	50	16	features	feature	NOUN
bam-4840	50	17	in	in	ADP
bam-4840	50	18	the	the	DET
bam-4840	50	19	protein	protein	NOUN
bam-4840	50	20	,	,	PUNCT
bam-4840	50	21	and	and	CCONJ
bam-4840	50	22	conformational	conformational	ADJ
bam-4840	50	23	rigidity	rigidity	NOUN
bam-4840	50	24	.	.	PUNCT
bam-4840	51	1	while	while	SCONJ
bam-4840	51	2	the	the	DET
bam-4840	51	3	dhpr	dhpr	NOUN
bam-4840	51	4	has	have	VERB
bam-4840	51	5	distinctive	distinctive	ADJ
bam-4840	51	6	features	feature	NOUN
bam-4840	51	7	and	and	CCONJ
bam-4840	51	8	its	its	PRON
bam-4840	51	9	mw	mw	NOUN
bam-4840	51	10	of	of	ADP
bam-4840	51	11	~450	~450	X
bam-4840	51	12	kda	kda	NOUN
bam-4840	51	13	is	be	AUX
bam-4840	51	14	larger	large	ADJ
bam-4840	51	15	than	than	ADP
bam-4840	51	16	most	most	ADJ
bam-4840	51	17	proteins	protein	NOUN
bam-4840	51	18	,	,	PUNCT
bam-4840	51	19	it	it	PRON
bam-4840	51	20	is	be	AUX
bam-4840	51	21	slightly	slightly	ADV
bam-4840	51	22	small	small	ADJ
bam-4840	51	23	for	for	ADP
bam-4840	51	24	single	single	ADJ
bam-4840	51	25	particle	particle	NOUN
bam-4840	51	26	image	image	NOUN
bam-4840	51	27	processing	processing	NOUN
bam-4840	51	28	,	,	PUNCT
bam-4840	51	29	and	and	CCONJ
bam-4840	51	30	has	have	VERB
bam-4840	51	31	a	a	DET
bam-4840	51	32	flexible	flexible	ADJ
bam-4840	51	33	region	region	NOUN
bam-4840	51	34	.	.	PUNCT
bam-4840	52	1	in	in	ADP
bam-4840	52	2	this	this	DET
bam-4840	52	3	context	context	NOUN
bam-4840	52	4	ryr1	ryr1	NOUN
bam-4840	52	5	,	,	PUNCT
bam-4840	52	6	five	five	NUM
bam-4840	52	7	times	time	NOUN
bam-4840	52	8	larger	large	ADJ
bam-4840	52	9	than	than	ADP
bam-4840	52	10	dhpr	dhpr	ADJ
bam-4840	52	11	and	and	CCONJ
bam-4840	52	12	more	more	ADV
bam-4840	52	13	rigid	rigid	ADJ
bam-4840	52	14	,	,	PUNCT
bam-4840	52	15	is	be	AUX
bam-4840	52	16	a	a	DET
bam-4840	52	17	much	much	ADV
bam-4840	52	18	better	well	ADJ
bam-4840	52	19	candidate	candidate	NOUN
bam-4840	52	20	for	for	ADP
bam-4840	52	21	this	this	DET
bam-4840	52	22	technique	technique	NOUN
bam-4840	52	23	,	,	PUNCT
bam-4840	52	24	which	which	PRON
bam-4840	52	25	has	have	AUX
bam-4840	52	26	enabled	enable	VERB
bam-4840	52	27	its	its	PRON
bam-4840	52	28	3d	3d	PROPN
bam-4840	52	29	reconstruction	reconstruction	NOUN
bam-4840	52	30	to	to	ADP
bam-4840	52	31	10	10	NUM
bam-4840	52	32	å	å	NOUN
bam-4840	52	33	resolution	resolution	NOUN
bam-4840	52	34	revealing	reveal	VERB
bam-4840	52	35	secondary	secondary	ADJ
bam-4840	52	36	structure	structure	NOUN
bam-4840	52	37	.	.	PUNCT
bam-4840	53	1	28	28	NUM
bam-4840	53	2	for	for	ADP
bam-4840	53	3	dhpr	dhpr	ADJ
bam-4840	53	4	,	,	PUNCT
bam-4840	53	5	both	both	PRON
bam-4840	53	6	negative	negative	ADJ
bam-4840	53	7	staining	staining	NOUN
bam-4840	53	8	and	and	CCONJ
bam-4840	53	9	cryoem	cryoem	NOUN
bam-4840	53	10	have	have	AUX
bam-4840	53	11	been	be	AUX
bam-4840	53	12	applied	apply	VERB
bam-4840	53	13	;	;	PUNCT
bam-4840	53	14	the	the	DET
bam-4840	53	15	best	good	ADJ
bam-4840	53	16	resolution	resolution	NOUN
bam-4840	53	17	achieved	achieve	VERB
bam-4840	53	18	so	so	ADV
bam-4840	53	19	far	far	ADV
bam-4840	53	20	is	be	AUX
bam-4840	53	21	19	19	NUM
bam-4840	53	22	å	å	NOUN
bam-4840	53	23	by	by	ADP
bam-4840	53	24	negative	negative	ADJ
bam-4840	53	25	staining	staining	NOUN
bam-4840	53	26	.	.	PUNCT
bam-4840	54	1	25	25	NUM
bam-4840	54	2	three­dimensional	three­dimensional	ADJ
bam-4840	54	3	structure	structure	NOUN
bam-4840	54	4	of	of	ADP
bam-4840	54	5	the	the	DET
bam-4840	54	6	dihydropyridine	dihydropyridine	NOUN
bam-4840	54	7	receptor	receptor	NOUN
bam-4840	54	8	complex	complex	NOUN
bam-4840	54	9	the	the	DET
bam-4840	54	10	3d	3d	NUM
bam-4840	54	11	structures	structure	NOUN
bam-4840	54	12	of	of	ADP
bam-4840	54	13	skeletal	skeletal	ADJ
bam-4840	54	14	dhpr	dhpr	NOUN
bam-4840	54	15	that	that	PRON
bam-4840	54	16	have	have	AUX
bam-4840	54	17	remained	remain	VERB
bam-4840	54	18	consistent	consistent	ADJ
bam-4840	54	19	with	with	ADP
bam-4840	54	20	the	the	DET
bam-4840	54	21	increase	increase	NOUN
bam-4840	54	22	in	in	ADP
bam-4840	54	23	resolution	resolution	NOUN
bam-4840	54	24	25,29,30	25,29,30	NUM
bam-4840	54	25	show	show	VERB
bam-4840	54	26	a	a	DET
bam-4840	54	27	main	main	ADJ
bam-4840	54	28	globular	globular	ADJ
bam-4840	54	29	body	body	NOUN
bam-4840	54	30	with	with	ADP
bam-4840	54	31	an	an	DET
bam-4840	54	32	3d	3d	NUM
bam-4840	54	33	structure	structure	NOUN
bam-4840	54	34	of	of	ADP
bam-4840	54	35	muscle	muscle	NOUN
bam-4840	54	36	dihydropyridine	dihydropyridine	NOUN
bam-4840	54	37	receptor	receptor	PROPN
bam-4840	54	38	eur	eur	PROPN
bam-4840	54	39	j	j	PROPN
bam-4840	54	40	transl	transl	PROPN
bam-4840	54	41	myol	myol	PROPN
bam-4840	54	42	basic	basic	ADJ
bam-4840	54	43	appl	appl	NOUN
bam-4840	54	44	myol	myol	NOUN
bam-4840	54	45	2015	2015	NUM
bam-4840	54	46	;	;	PUNCT
bam-4840	54	47	25	25	NUM
bam-4840	54	48	(	(	PUNCT
bam-4840	54	49	1	1	NUM
bam-4840	54	50	):	):	PUNCT
bam-4840	54	51	27	27	NUM
bam-4840	54	52	-	-	SYM
bam-4840	54	53	33	33	NUM
bam-4840	54	54	29	29	NUM
bam-4840	54	55	appendage	appendage	NOUN
bam-4840	54	56	emerging	emerge	VERB
bam-4840	54	57	from	from	ADP
bam-4840	54	58	it	it	PRON
bam-4840	54	59	.	.	PUNCT
bam-4840	55	1	the	the	DET
bam-4840	55	2	structural	structural	ADJ
bam-4840	55	3	description	description	NOUN
bam-4840	55	4	will	will	AUX
bam-4840	55	5	be	be	AUX
bam-4840	55	6	centered	center	VERB
bam-4840	55	7	in	in	ADP
bam-4840	55	8	our	our	PRON
bam-4840	55	9	negative	negative	ADJ
bam-4840	55	10	staining	stain	VERB
bam-4840	55	11	3d	3d	PROPN
bam-4840	55	12	reconstruction	reconstruction	NOUN
bam-4840	55	13	,	,	PUNCT
bam-4840	55	14	which	which	PRON
bam-4840	55	15	has	have	VERB
bam-4840	55	16	the	the	DET
bam-4840	55	17	highest	high	ADJ
bam-4840	55	18	resolution	resolution	NOUN
bam-4840	55	19	to	to	ADP
bam-4840	55	20	date	date	NOUN
bam-4840	55	21	(	(	PUNCT
bam-4840	55	22	19	19	NUM
bam-4840	55	23	å	å	NOUN
bam-4840	55	24	)	)	PUNCT
bam-4840	55	25	and	and	CCONJ
bam-4840	55	26	enabled	enable	VERB
bam-4840	55	27	placing	placing	NOUN
bam-4840	55	28	of	of	ADP
bam-4840	55	29	the	the	DET
bam-4840	55	30	1s	1s	NOUN
bam-4840	55	31	and	and	CCONJ
bam-4840	55	32	1a	1a	VERB
bam-4840	55	33	subunits	subunit	NOUN
bam-4840	55	34	for	for	ADP
bam-4840	55	35	the	the	DET
bam-4840	55	36	first	first	ADJ
bam-4840	55	37	time	time	NOUN
bam-4840	55	38	.	.	PUNCT
bam-4840	56	1	25	25	NUM
bam-4840	56	2	the	the	DET
bam-4840	56	3	dhpr	dhpr	NOUN
bam-4840	56	4	used	use	VERB
bam-4840	56	5	to	to	PART
bam-4840	56	6	obtain	obtain	VERB
bam-4840	56	7	these	these	DET
bam-4840	56	8	images	image	NOUN
bam-4840	56	9	had	have	VERB
bam-4840	56	10	a	a	DET
bam-4840	56	11	heterologous	heterologous	ADJ
bam-4840	56	12	1a	1a	NOUN
bam-4840	56	13	subunit	subunit	NOUN
bam-4840	56	14	that	that	PRON
bam-4840	56	15	contained	contain	VERB
bam-4840	56	16	an	an	DET
bam-4840	56	17	yfp	yfp	NOUN
bam-4840	56	18	to	to	PART
bam-4840	56	19	aid	aid	VERB
bam-4840	56	20	in	in	ADP
bam-4840	56	21	3d	3d	NUM
bam-4840	56	22	sub‐localization	sub‐localization	NOUN
bam-4840	56	23	and	and	CCONJ
bam-4840	56	24	a	a	DET
bam-4840	56	25	biotin‐acceptor	biotin‐acceptor	NOUN
bam-4840	56	26	domain	domain	NOUN
bam-4840	56	27	tag	tag	NOUN
bam-4840	56	28	that	that	PRON
bam-4840	56	29	was	be	AUX
bam-4840	56	30	used	use	VERB
bam-4840	56	31	for	for	ADP
bam-4840	56	32	purification	purification	NOUN
bam-4840	56	33	;	;	PUNCT
bam-4840	56	34	the	the	DET
bam-4840	56	35	engineered	engineer	VERB
bam-4840	56	36	1a	1a	NOUN
bam-4840	56	37	subunit	subunit	NOUN
bam-4840	56	38	was	be	AUX
bam-4840	56	39	expressed	express	VERB
bam-4840	56	40	in	in	ADP
bam-4840	56	41	transgenic	transgenic	NOUN
bam-4840	56	42	mouse	mouse	NOUN
bam-4840	56	43	as	as	SCONJ
bam-4840	56	44	indicated	indicate	VERB
bam-4840	56	45	above	above	ADV
bam-4840	56	46	.	.	PUNCT
bam-4840	57	1	after	after	ADP
bam-4840	57	2	purification	purification	NOUN
bam-4840	57	3	from	from	ADP
bam-4840	57	4	the	the	DET
bam-4840	57	5	muscle	muscle	NOUN
bam-4840	57	6	tissue	tissue	NOUN
bam-4840	57	7	,	,	PUNCT
bam-4840	57	8	the	the	DET
bam-4840	57	9	dhpr	dhpr	ADJ
bam-4840	57	10	sample	sample	NOUN
bam-4840	57	11	was	be	AUX
bam-4840	57	12	negatively	negatively	ADV
bam-4840	57	13	stained	stain	VERB
bam-4840	57	14	,	,	PUNCT
bam-4840	57	15	imaged	image	VERB
bam-4840	57	16	by	by	ADP
bam-4840	57	17	tem	tem	PROPN
bam-4840	57	18	(	(	PUNCT
bam-4840	57	19	fig	fig	NOUN
bam-4840	57	20	.	.	PUNCT
bam-4840	58	1	1	1	NUM
bam-4840	58	2	)	)	PUNCT
bam-4840	58	3	,	,	PUNCT
bam-4840	58	4	and	and	CCONJ
bam-4840	58	5	its	its	PRON
bam-4840	58	6	3d	3d	PROPN
bam-4840	58	7	reconstruction	reconstruction	NOUN
bam-4840	58	8	was	be	AUX
bam-4840	58	9	determined	determine	VERB
bam-4840	58	10	by	by	ADP
bam-4840	58	11	single	single	ADJ
bam-4840	58	12	particle	particle	NOUN
bam-4840	58	13	analysis	analysis	NOUN
bam-4840	58	14	,	,	PUNCT
bam-4840	58	15	using	use	VERB
bam-4840	58	16	around	around	ADV
bam-4840	58	17	12,000	12,000	NUM
bam-4840	58	18	particles	particle	NOUN
bam-4840	58	19	.	.	PUNCT
bam-4840	59	1	its	its	PRON
bam-4840	59	2	dimensions	dimension	NOUN
bam-4840	59	3	are	be	AUX
bam-4840	59	4	17	17	NUM
bam-4840	59	5	x	x	SYM
bam-4840	59	6	11	11	NUM
bam-4840	59	7	x	x	SYM
bam-4840	59	8	8	8	NUM
bam-4840	59	9	nm	nm	PRON
bam-4840	59	10	3	3	NUM
bam-4840	59	11	for	for	ADP
bam-4840	59	12	the	the	DET
bam-4840	59	13	main	main	ADJ
bam-4840	59	14	body	body	NOUN
bam-4840	59	15	and	and	CCONJ
bam-4840	59	16	an	an	DET
bam-4840	59	17	appendage	appendage	NOUN
bam-4840	59	18	that	that	PRON
bam-4840	59	19	extends	extend	VERB
bam-4840	59	20	7	7	NUM
bam-4840	59	21	nm	nm	NOUN
bam-4840	59	22	from	from	ADP
bam-4840	59	23	the	the	DET
bam-4840	59	24	point	point	NOUN
bam-4840	59	25	of	of	ADP
bam-4840	59	26	attachment	attachment	NOUN
bam-4840	59	27	to	to	ADP
bam-4840	59	28	the	the	DET
bam-4840	59	29	main	main	ADJ
bam-4840	59	30	body	body	NOUN
bam-4840	59	31	(	(	PUNCT
bam-4840	59	32	fig	fig	NOUN
bam-4840	59	33	.	.	PUNCT
bam-4840	60	1	2a‐b	2a‐b	ADV
bam-4840	60	2	)	)	PUNCT
bam-4840	60	3	.	.	PUNCT
bam-4840	61	1	the	the	DET
bam-4840	61	2	main	main	ADJ
bam-4840	61	3	body	body	NOUN
bam-4840	61	4	shows	show	VERB
bam-4840	61	5	a	a	DET
bam-4840	61	6	flat	flat	ADJ
bam-4840	61	7	oblong	oblong	ADJ
bam-4840	61	8	shape	shape	NOUN
bam-4840	61	9	with	with	ADP
bam-4840	61	10	five	five	NUM
bam-4840	61	11	pronounced	pronounced	ADJ
bam-4840	61	12	corners	corner	NOUN
bam-4840	61	13	around	around	ADP
bam-4840	61	14	its	its	PRON
bam-4840	61	15	contour	contour	NOUN
bam-4840	61	16	,	,	PUNCT
bam-4840	61	17	and	and	CCONJ
bam-4840	61	18	a	a	DET
bam-4840	61	19	small	small	ADJ
bam-4840	61	20	protrusion	protrusion	NOUN
bam-4840	61	21	on	on	ADP
bam-4840	61	22	its	its	PRON
bam-4840	61	23	base	base	NOUN
bam-4840	61	24	,	,	PUNCT
bam-4840	61	25	opposite	opposite	ADJ
bam-4840	61	26	to	to	ADP
bam-4840	61	27	the	the	DET
bam-4840	61	28	side	side	NOUN
bam-4840	61	29	where	where	SCONJ
bam-4840	61	30	the	the	DET
bam-4840	61	31	appendage	appendage	NOUN
bam-4840	61	32	is	be	AUX
bam-4840	61	33	attached	attach	VERB
bam-4840	61	34	.	.	PUNCT
bam-4840	62	1	the	the	DET
bam-4840	62	2	engineered	engineer	VERB
bam-4840	62	3	yfp	yfp	NOUN
bam-4840	62	4	,	,	PUNCT
bam-4840	62	5	which	which	PRON
bam-4840	62	6	is	be	AUX
bam-4840	62	7	directly	directly	ADV
bam-4840	62	8	recognizable	recognizable	ADJ
bam-4840	62	9	in	in	ADP
bam-4840	62	10	the	the	DET
bam-4840	62	11	structure	structure	NOUN
bam-4840	62	12	,	,	PUNCT
bam-4840	62	13	together	together	ADV
bam-4840	62	14	with	with	ADP
bam-4840	62	15	antibody	antibody	NOUN
bam-4840	62	16	labeling	labeling	NOUN
bam-4840	62	17	in	in	ADP
bam-4840	62	18	this	this	PRON
bam-4840	62	19	and	and	CCONJ
bam-4840	62	20	previous	previous	ADJ
bam-4840	62	21	works	work	NOUN
bam-4840	62	22	,	,	PUNCT
bam-4840	62	23	identifies	identify	VERB
bam-4840	62	24	several	several	ADJ
bam-4840	62	25	subunits	subunit	NOUN
bam-4840	62	26	and	and	CCONJ
bam-4840	62	27	functional	functional	ADJ
bam-4840	62	28	regions	region	NOUN
bam-4840	62	29	within	within	ADP
bam-4840	62	30	the	the	DET
bam-4840	62	31	complex	complex	NOUN
bam-4840	62	32	.	.	PUNCT
bam-4840	63	1	cav1.1	cav1.1	NOUN
bam-4840	63	2	or	or	CCONJ
bam-4840	63	3	1s	1s	X
bam-4840	63	4	is	be	AUX
bam-4840	63	5	the	the	DET
bam-4840	63	6	largest	large	ADJ
bam-4840	63	7	subunit	subunit	NOUN
bam-4840	63	8	(	(	PUNCT
bam-4840	63	9	176	176	NUM
bam-4840	63	10	kda	kda	NOUN
bam-4840	63	11	)	)	PUNCT
bam-4840	63	12	and	and	CCONJ
bam-4840	63	13	contributes	contribute	VERB
bam-4840	63	14	the	the	DET
bam-4840	63	15	voltage‐sensing	voltage‐sensing	NOUN
bam-4840	63	16	feature	feature	NOUN
bam-4840	63	17	.	.	PUNCT
bam-4840	64	1	it	it	PRON
bam-4840	64	2	has	have	VERB
bam-4840	64	3	a	a	DET
bam-4840	64	4	similar	similar	ADJ
bam-4840	64	5	molecular	molecular	ADJ
bam-4840	64	6	organization	organization	NOUN
bam-4840	64	7	to	to	ADP
bam-4840	64	8	that	that	PRON
bam-4840	64	9	found	find	VERB
bam-4840	64	10	in	in	ADP
bam-4840	64	11	voltage	voltage	NOUN
bam-4840	64	12	sensitive	sensitive	ADJ
bam-4840	64	13	k	k	PROPN
bam-4840	65	1	+	+	CCONJ
bam-4840	65	2	and	and	CCONJ
bam-4840	65	3	na	na	ADP
bam-4840	65	4	+	+	NUM
bam-4840	65	5	channels	channel	NOUN
bam-4840	66	1	and	and	CCONJ
bam-4840	66	2	it	it	PRON
bam-4840	66	3	is	be	AUX
bam-4840	66	4	assumed	assume	VERB
bam-4840	66	5	that	that	SCONJ
bam-4840	66	6	the	the	DET
bam-4840	66	7	tertiary	tertiary	ADJ
bam-4840	66	8	structure	structure	NOUN
bam-4840	66	9	is	be	AUX
bam-4840	66	10	also	also	ADV
bam-4840	66	11	the	the	DET
bam-4840	66	12	same	same	ADJ
bam-4840	66	13	;	;	PUNCT
bam-4840	66	14	31	31	NUM
bam-4840	66	15	their	their	PRON
bam-4840	66	16	canonical	canonical	ADJ
bam-4840	66	17	organization	organization	NOUN
bam-4840	66	18	consists	consist	VERB
bam-4840	66	19	of	of	ADP
bam-4840	66	20	four	four	NUM
bam-4840	66	21	repeats	repeat	NOUN
bam-4840	66	22	with	with	ADP
bam-4840	66	23	six	six	NUM
bam-4840	66	24	transmembrane	transmembrane	NOUN
bam-4840	66	25	each	each	PRON
bam-4840	66	26	,	,	PUNCT
bam-4840	66	27	s1‐s6	s1‐s6	NOUN
bam-4840	66	28	,	,	PUNCT
bam-4840	66	29	where	where	SCONJ
bam-4840	66	30	s1‐s4	s1‐s4	PRON
bam-4840	66	31	form	form	VERB
bam-4840	66	32	the	the	DET
bam-4840	66	33	peripheral	peripheral	ADJ
bam-4840	66	34	voltage	voltage	NOUN
bam-4840	66	35	sensors	sensor	NOUN
bam-4840	66	36	,	,	PUNCT
bam-4840	66	37	and	and	CCONJ
bam-4840	66	38	s5‐s6	s5‐s6	ADJ
bam-4840	66	39	from	from	ADP
bam-4840	66	40	each	each	DET
bam-4840	66	41	subunit	subunit	NOUN
bam-4840	66	42	combine	combine	VERB
bam-4840	66	43	in	in	ADP
bam-4840	66	44	the	the	DET
bam-4840	66	45	center	center	NOUN
bam-4840	66	46	to	to	PART
bam-4840	66	47	form	form	VERB
bam-4840	66	48	the	the	DET
bam-4840	66	49	cation	cation	NOUN
bam-4840	66	50	channel	channel	NOUN
bam-4840	66	51	,	,	PUNCT
bam-4840	66	52	forming	form	VERB
bam-4840	66	53	an	an	DET
bam-4840	66	54	overall	overall	ADJ
bam-4840	66	55	square	square	ADJ
bam-4840	66	56	prism	prism	NOUN
bam-4840	66	57	structure	structure	NOUN
bam-4840	66	58	with	with	ADP
bam-4840	66	59	protruding	protrude	VERB
bam-4840	66	60	corners	corner	NOUN
bam-4840	66	61	,	,	PUNCT
bam-4840	66	62	and	and	CCONJ
bam-4840	66	63	a	a	DET
bam-4840	66	64	footprint	footprint	NOUN
bam-4840	66	65	of	of	ADP
bam-4840	66	66	9	9	NUM
bam-4840	66	67	x	x	SYM
bam-4840	66	68	9	9	NUM
bam-4840	66	69	nm	nm	NOUN
bam-4840	66	70	2	2	NUM
bam-4840	66	71	.	.	PUNCT
bam-4840	67	1	for	for	ADP
bam-4840	67	2	each	each	DET
bam-4840	67	3	subunit	subunit	NOUN
bam-4840	67	4	,	,	PUNCT
bam-4840	67	5	an	an	DET
bam-4840	67	6	additional	additional	ADJ
bam-4840	67	7	pore	pore	ADJ
bam-4840	67	8	helix	helix	NOUN
bam-4840	67	9	between	between	ADP
bam-4840	67	10	s5‐s6	s5‐s6	ADJ
bam-4840	67	11	fig	fig	NOUN
bam-4840	67	12	1	1	NUM
bam-4840	67	13	.	.	PUNCT
bam-4840	67	14	electron	electron	NOUN
bam-4840	67	15	microscopy	microscopy	NOUN
bam-4840	67	16	of	of	ADP
bam-4840	67	17	negatively	negatively	ADV
bam-4840	67	18	stained	stain	VERB
bam-4840	67	19	dhpr	dhpr	NOUN
bam-4840	67	20	.	.	PUNCT
bam-4840	68	1	the	the	DET
bam-4840	68	2	main	main	ADJ
bam-4840	68	3	globular	globular	ADJ
bam-4840	68	4	body	body	NOUN
bam-4840	68	5	with	with	ADP
bam-4840	68	6	an	an	DET
bam-4840	68	7	appendage	appendage	NOUN
bam-4840	68	8	is	be	AUX
bam-4840	68	9	visible	visible	ADJ
bam-4840	68	10	in	in	ADP
bam-4840	68	11	the	the	DET
bam-4840	68	12	raw	raw	ADJ
bam-4840	68	13	images	image	NOUN
bam-4840	68	14	.	.	PUNCT
bam-4840	69	1	scale	scale	NOUN
bam-4840	69	2	bar	bar	NOUN
bam-4840	69	3	,	,	PUNCT
bam-4840	69	4	20	20	NUM
bam-4840	69	5	nm	nm	NOUN
bam-4840	69	6	.	.	PUNCT
bam-4840	69	7	fig	fig	PROPN
bam-4840	70	1	2	2	NUM
bam-4840	70	2	.	.	PUNCT
bam-4840	70	3	3d	3d	NUM
bam-4840	70	4	reconstruction	reconstruction	NOUN
bam-4840	70	5	of	of	ADP
bam-4840	70	6	the	the	DET
bam-4840	70	7	dhpr	dhpr	NOUN
bam-4840	70	8	and	and	CCONJ
bam-4840	70	9	docking	docking	NOUN
bam-4840	70	10	of	of	ADP
bam-4840	70	11	the	the	DET
bam-4840	70	12	1s	1s	NOUN
bam-4840	70	13	and	and	CCONJ
bam-4840	70	14	subunits	subunit	NOUN
bam-4840	70	15	.	.	PUNCT
bam-4840	71	1	a	a	X
bam-4840	71	2	-	-	PUNCT
bam-4840	71	3	b.	b.	NOUN
bam-4840	71	4	the	the	DET
bam-4840	71	5	boundaries	boundary	NOUN
bam-4840	71	6	of	of	ADP
bam-4840	71	7	the	the	DET
bam-4840	71	8	1s	1	NOUN
bam-4840	71	9	,	,	PUNCT
bam-4840	71	10	2	2	PUNCT
bam-4840	71	11	and	and	CCONJ
bam-4840	71	12	subunits	subunit	NOUN
bam-4840	71	13	within	within	ADP
bam-4840	71	14	the	the	DET
bam-4840	71	15	3d	3d	NOUN
bam-4840	71	16	reconstruction	reconstruction	NOUN
bam-4840	71	17	of	of	ADP
bam-4840	71	18	the	the	DET
bam-4840	71	19	dhpr	dhpr	NOUN
bam-4840	71	20	are	be	AUX
bam-4840	71	21	indicated	indicate	VERB
bam-4840	71	22	in	in	ADP
bam-4840	71	23	the	the	DET
bam-4840	71	24	two	two	NUM
bam-4840	71	25	orthogonal	orthogonal	ADJ
bam-4840	71	26	views	view	NOUN
bam-4840	71	27	.	.	PUNCT
bam-4840	72	1	c	c	X
bam-4840	72	2	-	-	PUNCT
bam-4840	72	3	d.	d.	VERB
bam-4840	72	4	molecular	molecular	ADJ
bam-4840	72	5	boundaries	boundary	NOUN
bam-4840	72	6	of	of	ADP
bam-4840	72	7	1s	1	NOUN
bam-4840	72	8	:	:	PUNCT
bam-4840	72	9	docking	docking	NOUN
bam-4840	72	10	of	of	ADP
bam-4840	72	11	the	the	DET
bam-4840	72	12	atomic	atomic	ADJ
bam-4840	72	13	structure	structure	NOUN
bam-4840	72	14	of	of	ADP
bam-4840	72	15	a	a	DET
bam-4840	72	16	representative	representative	ADJ
bam-4840	72	17	voltage‐gated	voltage‐gate	VERB
bam-4840	72	18	cation	cation	NOUN
bam-4840	72	19	channel	channel	NOUN
bam-4840	72	20	(	(	PUNCT
bam-4840	72	21	navab	navab	PROPN
bam-4840	72	22	32	32	NUM
bam-4840	72	23	)	)	PUNCT
bam-4840	72	24	,	,	PUNCT
bam-4840	72	25	and	and	CCONJ
bam-4840	72	26	location	location	NOUN
bam-4840	72	27	of	of	ADP
bam-4840	72	28	the	the	DET
bam-4840	72	29	ii‐iii	ii‐iii	PROPN
bam-4840	72	30	loop	loop	NOUN
bam-4840	72	31	.	.	PUNCT
bam-4840	73	1	e­f	e­f	X
bam-4840	73	2	.	.	PUNCT
bam-4840	74	1	docking	docking	NOUN
bam-4840	74	2	of	of	ADP
bam-4840	74	3	the	the	DET
bam-4840	74	4	crystal	crystal	NOUN
bam-4840	74	5	structure	structure	NOUN
bam-4840	74	6	of	of	ADP
bam-4840	74	7	a	a	DET
bam-4840	74	8	subunit	subunit	NOUN
bam-4840	74	9	35	35	NUM
bam-4840	74	10	with	with	ADP
bam-4840	74	11	the	the	DET
bam-4840	74	12	sh3	sh3	PROPN
bam-4840	74	13	and	and	CCONJ
bam-4840	74	14	gk	gk	PROPN
bam-4840	74	15	domains	domain	NOUN
bam-4840	74	16	indicated	indicate	VERB
bam-4840	74	17	in	in	ADP
bam-4840	74	18	light	light	NOUN
bam-4840	74	19	and	and	CCONJ
bam-4840	74	20	dark	dark	ADJ
bam-4840	74	21	blue	blue	NOUN
bam-4840	74	22	,	,	PUNCT
bam-4840	74	23	respectively	respectively	ADV
bam-4840	74	24	.	.	PUNCT
bam-4840	75	1	the	the	DET
bam-4840	75	2	barrel‐shape	barrel‐shape	NOUN
bam-4840	75	3	of	of	ADP
bam-4840	75	4	yfp	yfp	NOUN
bam-4840	75	5	(	(	PUNCT
bam-4840	75	6	yellow	yellow	ADJ
bam-4840	75	7	)	)	PUNCT
bam-4840	75	8	,	,	PUNCT
bam-4840	75	9	engineered	engineer	VERB
bam-4840	75	10	in	in	ADP
bam-4840	75	11	the	the	DET
bam-4840	75	12	n	n	DET
bam-4840	75	13	terminus	terminus	NOUN
bam-4840	75	14	of	of	ADP
bam-4840	75	15	a	a	NOUN
bam-4840	75	16	,	,	PUNCT
bam-4840	75	17	is	be	AUX
bam-4840	75	18	recognizable	recognizable	ADJ
bam-4840	75	19	in	in	ADP
bam-4840	75	20	the	the	DET
bam-4840	75	21	3d	3d	NUM
bam-4840	75	22	structure	structure	NOUN
bam-4840	75	23	.	.	PUNCT
bam-4840	76	1	the	the	DET
bam-4840	76	2	aid	aid	NOUN
bam-4840	76	3	sequence	sequence	NOUN
bam-4840	76	4	of	of	ADP
bam-4840	76	5	1s	1	NOUN
bam-4840	76	6	'	'	PART
bam-4840	76	7	i‐ii	i‐ii	ADJ
bam-4840	76	8	loop	loop	NOUN
bam-4840	76	9	(	(	PUNCT
bam-4840	76	10	green	green	NOUN
bam-4840	76	11	)	)	PUNCT
bam-4840	76	12	that	that	PRON
bam-4840	76	13	co‐crystallized	co‐crystallize	VERB
bam-4840	76	14	with	with	ADP
bam-4840	76	15	the	the	DET
bam-4840	76	16	subunits	subunit	NOUN
bam-4840	76	17	makes	make	VERB
bam-4840	76	18	contact	contact	NOUN
bam-4840	76	19	with	with	ADP
bam-4840	76	20	the	the	DET
bam-4840	76	21	1s	1	NOUN
bam-4840	76	22	subunit	subunit	NOUN
bam-4840	76	23	.	.	PUNCT
bam-4840	77	1	according	accord	VERB
bam-4840	77	2	to	to	ADP
bam-4840	77	3	functional	functional	ADJ
bam-4840	77	4	studies	study	NOUN
bam-4840	77	5	,	,	PUNCT
bam-4840	77	6	the	the	DET
bam-4840	77	7	subunit	subunit	PROPN
bam-4840	77	8	should	should	AUX
bam-4840	77	9	locate	locate	VERB
bam-4840	77	10	at	at	ADP
bam-4840	77	11	the	the	DET
bam-4840	77	12	interphase	interphase	NOUN
bam-4840	77	13	between	between	ADP
bam-4840	77	14	1s	1	NOUN
bam-4840	77	15	and	and	CCONJ
bam-4840	77	16	.	.	ADP
bam-4840	77	17	scale	scale	NOUN
bam-4840	77	18	bar	bar	NOUN
bam-4840	77	19	,	,	PUNCT
bam-4840	77	20	10	10	NUM
bam-4840	77	21	nm	nm	NOUN
bam-4840	77	22	.	.	PUNCT
bam-4840	78	1	3d	3d	NUM
bam-4840	78	2	structure	structure	NOUN
bam-4840	78	3	of	of	ADP
bam-4840	78	4	muscle	muscle	NOUN
bam-4840	78	5	dihydropyridine	dihydropyridine	NOUN
bam-4840	78	6	receptor	receptor	PROPN
bam-4840	78	7	eur	eur	PROPN
bam-4840	78	8	j	j	PROPN
bam-4840	78	9	transl	transl	PROPN
bam-4840	78	10	myol	myol	PROPN
bam-4840	78	11	basic	basic	ADJ
bam-4840	78	12	appl	appl	NOUN
bam-4840	78	13	myol	myol	NOUN
bam-4840	78	14	2015	2015	NUM
bam-4840	78	15	;	;	PUNCT
bam-4840	78	16	25	25	NUM
bam-4840	78	17	(	(	PUNCT
bam-4840	78	18	1	1	NUM
bam-4840	78	19	):	):	PUNCT
bam-4840	78	20	27	27	NUM
bam-4840	78	21	-	-	SYM
bam-4840	78	22	33	33	NUM
bam-4840	78	23	30	30	NUM
bam-4840	78	24	and	and	CCONJ
bam-4840	78	25	an	an	DET
bam-4840	78	26	s4‐s5	s4‐s5	NOUN
bam-4840	78	27	linker	linker	NOUN
bam-4840	78	28	do	do	AUX
bam-4840	78	29	not	not	PART
bam-4840	78	30	cross	cross	VERB
bam-4840	78	31	the	the	DET
bam-4840	78	32	membrane	membrane	NOUN
bam-4840	78	33	.	.	PUNCT
bam-4840	79	1	we	we	PRON
bam-4840	79	2	placed	place	VERB
bam-4840	79	3	the	the	DET
bam-4840	79	4	atomic	atomic	ADJ
bam-4840	79	5	structure	structure	NOUN
bam-4840	79	6	of	of	ADP
bam-4840	79	7	a	a	DET
bam-4840	79	8	voltage	voltage	NOUN
bam-4840	79	9	gated	gate	VERB
bam-4840	79	10	cation	cation	NOUN
bam-4840	79	11	channel	channel	NOUN
bam-4840	79	12	32	32	NUM
bam-4840	79	13	in	in	ADP
bam-4840	79	14	the	the	DET
bam-4840	79	15	main	main	ADJ
bam-4840	79	16	body	body	NOUN
bam-4840	79	17	of	of	ADP
bam-4840	79	18	the	the	DET
bam-4840	79	19	tem	tem	PROPN
bam-4840	79	20	derived	derive	VERB
bam-4840	79	21	structure	structure	NOUN
bam-4840	79	22	,	,	PUNCT
bam-4840	79	23	matching	match	VERB
bam-4840	79	24	two	two	NUM
bam-4840	79	25	contiguous	contiguous	ADJ
bam-4840	79	26	square	square	ADJ
bam-4840	79	27	corners	corner	NOUN
bam-4840	79	28	separated	separate	VERB
bam-4840	79	29	by	by	ADP
bam-4840	79	30	11	11	NUM
bam-4840	79	31	nm	nm	NOUN
bam-4840	79	32	(	(	PUNCT
bam-4840	79	33	fig	fig	NOUN
bam-4840	79	34	.	.	PUNCT
bam-4840	80	1	2c‐d	2c‐d	NOUN
bam-4840	80	2	)	)	PUNCT
bam-4840	80	3	.	.	PUNCT
bam-4840	81	1	we	we	PRON
bam-4840	81	2	attribute	attribute	VERB
bam-4840	81	3	the	the	DET
bam-4840	81	4	slightly	slightly	ADV
bam-4840	81	5	wider	wide	ADJ
bam-4840	81	6	dimensions	dimension	NOUN
bam-4840	81	7	of	of	ADP
bam-4840	81	8	the	the	DET
bam-4840	81	9	tem	tem	PROPN
bam-4840	81	10	structure	structure	NOUN
bam-4840	81	11	to	to	ADP
bam-4840	81	12	the	the	DET
bam-4840	81	13	presence	presence	NOUN
bam-4840	81	14	of	of	ADP
bam-4840	81	15	detergent	detergent	NOUN
bam-4840	81	16	surrounding	surround	VERB
bam-4840	81	17	the	the	DET
bam-4840	81	18	transmembrane	transmembrane	ADJ
bam-4840	81	19	domain	domain	NOUN
bam-4840	81	20	,	,	PUNCT
bam-4840	81	21	and	and	CCONJ
bam-4840	81	22	to	to	ADP
bam-4840	81	23	the	the	DET
bam-4840	81	24	lower	low	ADJ
bam-4840	81	25	resolution	resolution	NOUN
bam-4840	81	26	of	of	ADP
bam-4840	81	27	the	the	DET
bam-4840	81	28	tem	tem	PROPN
bam-4840	81	29	structure	structure	NOUN
bam-4840	81	30	.	.	PUNCT
bam-4840	82	1	two	two	NUM
bam-4840	82	2	voltage	voltage	NOUN
bam-4840	82	3	sensors	sensor	NOUN
bam-4840	82	4	would	would	AUX
bam-4840	82	5	be	be	AUX
bam-4840	82	6	totally	totally	ADV
bam-4840	82	7	exposed	expose	VERB
bam-4840	82	8	to	to	ADP
bam-4840	82	9	the	the	DET
bam-4840	82	10	periphery	periphery	NOUN
bam-4840	82	11	of	of	ADP
bam-4840	82	12	the	the	DET
bam-4840	82	13	structure	structure	NOUN
bam-4840	82	14	while	while	SCONJ
bam-4840	82	15	the	the	DET
bam-4840	82	16	other	other	ADJ
bam-4840	82	17	two	two	NUM
bam-4840	82	18	are	be	AUX
bam-4840	82	19	partially	partially	ADV
bam-4840	82	20	exposed	expose	VERB
bam-4840	82	21	to	to	ADP
bam-4840	82	22	the	the	DET
bam-4840	82	23	periphery	periphery	NOUN
bam-4840	82	24	and	and	CCONJ
bam-4840	82	25	partially	partially	ADV
bam-4840	82	26	interacting	interact	VERB
bam-4840	82	27	with	with	ADP
bam-4840	82	28	the	the	DET
bam-4840	82	29	rest	rest	NOUN
bam-4840	82	30	of	of	ADP
bam-4840	82	31	the	the	DET
bam-4840	82	32	main	main	ADJ
bam-4840	82	33	body	body	NOUN
bam-4840	82	34	.	.	PUNCT
bam-4840	83	1	a	a	DET
bam-4840	83	2	characteristic	characteristic	NOUN
bam-4840	83	3	of	of	ADP
bam-4840	83	4	mammalian	mammalian	ADJ
bam-4840	83	5	cav	cav	NOUN
bam-4840	83	6	channels	channel	NOUN
bam-4840	83	7	is	be	AUX
bam-4840	83	8	that	that	SCONJ
bam-4840	83	9	the	the	DET
bam-4840	83	10	four	four	NUM
bam-4840	83	11	repeated	repeat	VERB
bam-4840	83	12	units	unit	NOUN
bam-4840	83	13	(	(	PUNCT
bam-4840	83	14	i‐iv	i‐iv	NOUN
bam-4840	83	15	)	)	PUNCT
bam-4840	83	16	are	be	AUX
bam-4840	83	17	encoded	encode	VERB
bam-4840	83	18	in	in	ADP
bam-4840	83	19	a	a	DET
bam-4840	83	20	single	single	ADJ
bam-4840	83	21	polypeptide	polypeptide	ADJ
bam-4840	83	22	chain	chain	NOUN
bam-4840	83	23	of	of	ADP
bam-4840	83	24	almost	almost	ADV
bam-4840	83	25	1,900	1,900	NUM
bam-4840	83	26	residues	residue	NOUN
bam-4840	83	27	.	.	PUNCT
bam-4840	84	1	33	33	NUM
bam-4840	84	2	this	this	PRON
bam-4840	84	3	allows	allow	VERB
bam-4840	84	4	for	for	ADP
bam-4840	84	5	differences	difference	NOUN
bam-4840	84	6	in	in	ADP
bam-4840	84	7	sequence	sequence	NOUN
bam-4840	84	8	among	among	ADP
bam-4840	84	9	the	the	DET
bam-4840	84	10	four	four	NUM
bam-4840	84	11	repeats	repeat	NOUN
bam-4840	84	12	,	,	PUNCT
bam-4840	84	13	and	and	CCONJ
bam-4840	84	14	importantly	importantly	ADV
bam-4840	84	15	,	,	PUNCT
bam-4840	84	16	cytoplasmic	cytoplasmic	ADJ
bam-4840	84	17	loops	loop	NOUN
bam-4840	84	18	connecting	connect	VERB
bam-4840	84	19	these	these	DET
bam-4840	84	20	repeats	repeat	NOUN
bam-4840	84	21	have	have	VERB
bam-4840	84	22	distinct	distinct	ADJ
bam-4840	84	23	structural	structural	ADJ
bam-4840	84	24	and	and	CCONJ
bam-4840	84	25	functional	functional	ADJ
bam-4840	84	26	roles	role	NOUN
bam-4840	84	27	.	.	PUNCT
bam-4840	85	1	the	the	DET
bam-4840	85	2	i‐ii	i‐ii	PROPN
bam-4840	85	3	loop	loop	NOUN
bam-4840	85	4	(	(	PUNCT
bam-4840	85	5	residues	residue	NOUN
bam-4840	85	6	334‐432	334‐432	NUM
bam-4840	85	7	)	)	PUNCT
bam-4840	85	8	has	have	VERB
bam-4840	85	9	the	the	DET
bam-4840	85	10	alpha‐interacting	alpha‐interacting	NOUN
bam-4840	85	11	domain	domain	NOUN
bam-4840	85	12	(	(	PUNCT
bam-4840	85	13	aid	aid	NOUN
bam-4840	85	14	)	)	PUNCT
bam-4840	85	15	region	region	NOUN
bam-4840	85	16	(	(	PUNCT
bam-4840	85	17	residues	residue	NOUN
bam-4840	85	18	357‐374	357‐374	NUM
bam-4840	85	19	)	)	PUNCT
bam-4840	85	20	that	that	PRON
bam-4840	85	21	anchors	anchor	VERB
bam-4840	85	22	the	the	DET
bam-4840	85	23	1a	1a	NOUN
bam-4840	85	24	subunit	subunit	NOUN
bam-4840	85	25	.	.	PUNCT
bam-4840	86	1	34,35	34,35	ADJ
bam-4840	86	2	the	the	DET
bam-4840	86	3	ii‐iii	ii‐iii	PROPN
bam-4840	86	4	loop	loop	NOUN
bam-4840	86	5	(	(	PUNCT
bam-4840	86	6	residues	residue	NOUN
bam-4840	86	7	671‐790	671‐790	NOUN
bam-4840	86	8	)	)	PUNCT
bam-4840	86	9	,	,	PUNCT
bam-4840	86	10	longest	long	ADJ
bam-4840	86	11	and	and	CCONJ
bam-4840	86	12	partially	partially	ADV
bam-4840	86	13	unfolded	unfold	VERB
bam-4840	86	14	,	,	PUNCT
bam-4840	86	15	36	36	NUM
bam-4840	86	16	is	be	AUX
bam-4840	86	17	an	an	DET
bam-4840	86	18	important	important	ADJ
bam-4840	86	19	determinant	determinant	NOUN
bam-4840	86	20	of	of	ADP
bam-4840	86	21	ec	ec	PROPN
bam-4840	86	22	coupling	coupling	NOUN
bam-4840	86	23	;	;	PUNCT
bam-4840	86	24	17	17	NUM
bam-4840	86	25	the	the	DET
bam-4840	86	26	sequence	sequence	NOUN
bam-4840	86	27	formed	form	VERB
bam-4840	86	28	by	by	ADP
bam-4840	86	29	residues	residue	NOUN
bam-4840	86	30	720‐760	720‐760	PROPN
bam-4840	86	31	is	be	AUX
bam-4840	86	32	the	the	DET
bam-4840	86	33	critical	critical	ADJ
bam-4840	86	34	sequence	sequence	NOUN
bam-4840	86	35	for	for	ADP
bam-4840	86	36	ec	ec	PROPN
bam-4840	86	37	coupling	coupling	NOUN
bam-4840	86	38	.	.	PUNCT
bam-4840	87	1	18,37	18,37	NUM
bam-4840	87	2	the	the	DET
bam-4840	87	3	iii‐iv	iii‐iv	PROPN
bam-4840	87	4	loop	loop	NOUN
bam-4840	87	5	(	(	PUNCT
bam-4840	87	6	residues	residue	NOUN
bam-4840	87	7	1066‐1117	1066‐1117	NUM
bam-4840	87	8	)	)	PUNCT
bam-4840	87	9	influences	influence	NOUN
bam-4840	87	10	cav1.1	cav1.1	NOUN
bam-4840	87	11	current	current	ADJ
bam-4840	87	12	but	but	CCONJ
bam-4840	87	13	does	do	AUX
bam-4840	87	14	not	not	PART
bam-4840	87	15	appear	appear	VERB
bam-4840	87	16	to	to	PART
bam-4840	87	17	be	be	AUX
bam-4840	87	18	involved	involve	VERB
bam-4840	87	19	in	in	ADP
bam-4840	87	20	ec	ec	PROPN
bam-4840	87	21	coupling	couple	VERB
bam-4840	87	22	interactions	interaction	NOUN
bam-4840	87	23	with	with	ADP
bam-4840	87	24	the	the	DET
bam-4840	87	25	ryr1	ryr1	NOUN
bam-4840	87	26	,	,	PUNCT
bam-4840	87	27	38	38	NUM
bam-4840	87	28	however	however	ADV
bam-4840	87	29	its	its	PRON
bam-4840	87	30	importance	importance	NOUN
bam-4840	87	31	is	be	AUX
bam-4840	87	32	underscored	underscore	VERB
bam-4840	87	33	by	by	ADP
bam-4840	87	34	the	the	DET
bam-4840	87	35	fact	fact	NOUN
bam-4840	87	36	that	that	SCONJ
bam-4840	87	37	mutation	mutation	NOUN
bam-4840	87	38	at	at	ADP
bam-4840	87	39	residue	residue	NOUN
bam-4840	87	40	1086	1086	NUM
bam-4840	87	41	results	result	NOUN
bam-4840	87	42	in	in	ADP
bam-4840	87	43	malignant	malignant	ADJ
bam-4840	87	44	hyperthermia	hyperthermia	NOUN
bam-4840	87	45	.	.	PUNCT
bam-4840	88	1	5	5	NUM
bam-4840	88	2	cav1.1	cav1.1	NOUN
bam-4840	88	3	has	have	VERB
bam-4840	88	4	an	an	DET
bam-4840	88	5	extended	extended	ADJ
bam-4840	88	6	c	c	NOUN
bam-4840	88	7	'	'	PART
bam-4840	88	8	domain	domain	NOUN
bam-4840	88	9	of	of	ADP
bam-4840	88	10	~500	~500	NOUN
bam-4840	88	11	residues	residue	NOUN
bam-4840	88	12	;	;	PUNCT
bam-4840	88	13	its	its	PRON
bam-4840	88	14	distal	distal	ADJ
bam-4840	88	15	part	part	NOUN
bam-4840	88	16	is	be	AUX
bam-4840	88	17	proteolytically	proteolytically	ADV
bam-4840	88	18	cleaved	cleave	VERB
bam-4840	88	19	in	in	ADP
bam-4840	88	20	vivo	vivo	NOUN
bam-4840	88	21	and	and	CCONJ
bam-4840	88	22	in	in	ADP
bam-4840	88	23	general	general	ADJ
bam-4840	88	24	remains	remain	NOUN
bam-4840	88	25	associated	associate	VERB
bam-4840	88	26	through	through	ADP
bam-4840	88	27	non‐covalent	non‐covalent	ADJ
bam-4840	88	28	interactions	interaction	NOUN
bam-4840	88	29	.	.	PUNCT
bam-4840	89	1	39	39	NUM
bam-4840	89	2	tem	tem	NOUN
bam-4840	89	3	images	image	NOUN
bam-4840	89	4	of	of	ADP
bam-4840	89	5	the	the	DET
bam-4840	89	6	dhpr	dhpr	NOUN
bam-4840	89	7	incubated	incubate	VERB
bam-4840	89	8	with	with	ADP
bam-4840	89	9	antibodies	antibody	NOUN
bam-4840	89	10	against	against	ADP
bam-4840	89	11	the	the	DET
bam-4840	89	12	ii‐iii	ii‐iii	PROPN
bam-4840	89	13	loop	loop	NOUN
bam-4840	89	14	showed	show	VERB
bam-4840	89	15	that	that	SCONJ
bam-4840	89	16	these	these	PRON
bam-4840	89	17	bound	bind	VERB
bam-4840	89	18	to	to	ADP
bam-4840	89	19	the	the	DET
bam-4840	89	20	protuberance	protuberance	NOUN
bam-4840	89	21	emerging	emerge	VERB
bam-4840	89	22	from	from	ADP
bam-4840	89	23	the	the	DET
bam-4840	89	24	main	main	ADJ
bam-4840	89	25	body	body	NOUN
bam-4840	89	26	in	in	ADP
bam-4840	89	27	the	the	DET
bam-4840	89	28	center	center	NOUN
bam-4840	89	29	of	of	ADP
bam-4840	89	30	the	the	DET
bam-4840	89	31	region	region	NOUN
bam-4840	89	32	attributed	attribute	VERB
bam-4840	89	33	to	to	ADP
bam-4840	89	34	the	the	DET
bam-4840	89	35	transmembrane	transmembrane	ADJ
bam-4840	89	36	region	region	NOUN
bam-4840	89	37	of	of	ADP
bam-4840	89	38	cav1.1	cav1.1	PROPN
bam-4840	89	39	,	,	PUNCT
bam-4840	89	40	and	and	CCONJ
bam-4840	89	41	on	on	ADP
bam-4840	89	42	the	the	DET
bam-4840	89	43	opposite	opposite	ADJ
bam-4840	89	44	side	side	NOUN
bam-4840	89	45	of	of	ADP
bam-4840	89	46	the	the	DET
bam-4840	89	47	appendage	appendage	NOUN
bam-4840	89	48	,	,	PUNCT
bam-4840	89	49	25	25	NUM
bam-4840	89	50	indicating	indicate	VERB
bam-4840	89	51	that	that	SCONJ
bam-4840	89	52	this	this	DET
bam-4840	89	53	protuberance	protuberance	NOUN
bam-4840	89	54	contains	contain	VERB
bam-4840	89	55	the	the	DET
bam-4840	89	56	ii‐iii	ii‐iii	PROPN
bam-4840	89	57	loop	loop	NOUN
bam-4840	89	58	(	(	PUNCT
bam-4840	89	59	fig	fig	NOUN
bam-4840	89	60	.	.	PUNCT
bam-4840	90	1	2c‐d	2c‐d	NOUN
bam-4840	90	2	)	)	PUNCT
bam-4840	90	3	.	.	PUNCT
bam-4840	91	1	this	this	DET
bam-4840	91	2	region	region	NOUN
bam-4840	91	3	marks	mark	VERB
bam-4840	91	4	the	the	DET
bam-4840	91	5	intracellular	intracellular	ADJ
bam-4840	91	6	side	side	NOUN
bam-4840	91	7	of	of	ADP
bam-4840	91	8	cav1.1	cav1.1	NOUN
bam-4840	91	9	and	and	CCONJ
bam-4840	91	10	hence	hence	ADV
bam-4840	91	11	it	it	PRON
bam-4840	91	12	is	be	AUX
bam-4840	91	13	plausible	plausible	ADJ
bam-4840	91	14	that	that	SCONJ
bam-4840	91	15	it	it	PRON
bam-4840	91	16	also	also	ADV
bam-4840	91	17	contains	contain	VERB
bam-4840	91	18	at	at	ADP
bam-4840	91	19	least	least	ADJ
bam-4840	91	20	part	part	NOUN
bam-4840	91	21	of	of	ADP
bam-4840	91	22	the	the	DET
bam-4840	91	23	neighboring	neighboring	NOUN
bam-4840	91	24	ii‐ii	ii‐ii	NOUN
bam-4840	91	25	and	and	CCONJ
bam-4840	91	26	iii‐iv	iii‐iv	ADV
bam-4840	91	27	loops	loop	NOUN
bam-4840	91	28	,	,	PUNCT
bam-4840	91	29	and	and	CCONJ
bam-4840	91	30	the	the	DET
bam-4840	91	31	c	c	NOUN
bam-4840	91	32	'	'	PART
bam-4840	91	33	domain	domain	NOUN
bam-4840	91	34	17	17	NUM
bam-4840	91	35	.	.	PUNCT
bam-4840	92	1	α2	α2	ADJ
bam-4840	92	2	and	and	CCONJ
bam-4840	92	3	δ1	δ1	NOUN
bam-4840	92	4	subunits	subunit	NOUN
bam-4840	92	5	the	the	DET
bam-4840	92	6	extracellular	extracellular	ADJ
bam-4840	92	7	2	2	ADJ
bam-4840	92	8	subunit	subunit	NOUN
bam-4840	92	9	(	(	PUNCT
bam-4840	92	10	147	147	NUM
bam-4840	92	11	kda	kda	NOUN
bam-4840	92	12	)	)	PUNCT
bam-4840	92	13	was	be	AUX
bam-4840	92	14	previously	previously	ADV
bam-4840	92	15	assigned	assign	VERB
bam-4840	92	16	to	to	ADP
bam-4840	92	17	the	the	DET
bam-4840	92	18	appendage	appendage	NOUN
bam-4840	92	19	emerging	emerge	VERB
bam-4840	92	20	from	from	ADP
bam-4840	92	21	the	the	DET
bam-4840	92	22	main	main	ADJ
bam-4840	92	23	body	body	NOUN
bam-4840	92	24	,	,	PUNCT
bam-4840	92	25	using	use	VERB
bam-4840	92	26	antibody	antibody	NOUN
bam-4840	92	27	labeling	labeling	NOUN
bam-4840	92	28	.	.	PUNCT
bam-4840	93	1	29,30	29,30	NUM
bam-4840	93	2	together	together	ADV
bam-4840	93	3	with	with	ADP
bam-4840	93	4	the	the	DET
bam-4840	93	5	identification	identification	NOUN
bam-4840	93	6	of	of	ADP
bam-4840	93	7	the	the	DET
bam-4840	93	8	ii‐iii	ii‐iii	PROPN
bam-4840	93	9	loop	loop	NOUN
bam-4840	93	10	within	within	ADP
bam-4840	93	11	the	the	DET
bam-4840	93	12	cav1.1	cav1.1	NOUN
bam-4840	93	13	subunit	subunit	NOUN
bam-4840	93	14	,	,	PUNCT
bam-4840	93	15	this	this	PRON
bam-4840	93	16	establishes	establish	VERB
bam-4840	93	17	the	the	DET
bam-4840	93	18	orientation	orientation	NOUN
bam-4840	93	19	of	of	ADP
bam-4840	93	20	the	the	DET
bam-4840	93	21	dhpr	dhpr	ADJ
bam-4840	93	22	3d	3d	NUM
bam-4840	93	23	structure	structure	NOUN
bam-4840	93	24	within	within	ADP
bam-4840	93	25	the	the	DET
bam-4840	93	26	triad	triad	ADJ
bam-4840	93	27	junction	junction	NOUN
bam-4840	93	28	.	.	PUNCT
bam-4840	94	1	compared	compare	VERB
bam-4840	94	2	with	with	ADP
bam-4840	94	3	the	the	DET
bam-4840	94	4	main	main	ADJ
bam-4840	94	5	body	body	NOUN
bam-4840	94	6	of	of	ADP
bam-4840	94	7	the	the	DET
bam-4840	94	8	dhpr	dhpr	NOUN
bam-4840	94	9	,	,	PUNCT
bam-4840	94	10	the	the	DET
bam-4840	94	11	size	size	NOUN
bam-4840	94	12	and	and	CCONJ
bam-4840	94	13	shape	shape	NOUN
bam-4840	94	14	of	of	ADP
bam-4840	94	15	the	the	DET
bam-4840	94	16	appendage	appendage	NOUN
bam-4840	94	17	attributed	attribute	VERB
bam-4840	94	18	to	to	ADP
bam-4840	94	19	2	2	PUNCT
bam-4840	94	20	is	be	AUX
bam-4840	94	21	very	very	ADV
bam-4840	94	22	threshold‐dependent	threshold‐dependent	ADJ
bam-4840	94	23	.	.	PUNCT
bam-4840	95	1	this	this	PRON
bam-4840	95	2	is	be	AUX
bam-4840	95	3	indicative	indicative	ADJ
bam-4840	95	4	of	of	ADP
bam-4840	95	5	variability	variability	NOUN
bam-4840	95	6	within	within	ADP
bam-4840	95	7	this	this	DET
bam-4840	95	8	region	region	NOUN
bam-4840	95	9	,	,	PUNCT
bam-4840	95	10	which	which	PRON
bam-4840	95	11	is	be	AUX
bam-4840	95	12	compatible	compatible	ADJ
bam-4840	95	13	with	with	ADP
bam-4840	95	14	its	its	PRON
bam-4840	95	15	heavy	heavy	ADJ
bam-4840	95	16	glycosylation	glycosylation	NOUN
bam-4840	95	17	,	,	PUNCT
bam-4840	95	18	and	and	CCONJ
bam-4840	95	19	may	may	AUX
bam-4840	95	20	also	also	ADV
bam-4840	95	21	be	be	AUX
bam-4840	95	22	an	an	DET
bam-4840	95	23	indicator	indicator	NOUN
bam-4840	95	24	of	of	ADP
bam-4840	95	25	flexibility	flexibility	NOUN
bam-4840	95	26	.	.	PUNCT
bam-4840	96	1	the	the	DET
bam-4840	96	2	2	2	PUNCT
bam-4840	96	3	and	and	CCONJ
bam-4840	96	4	1	1	NOUN
bam-4840	96	5	subunits	subunit	NOUN
bam-4840	96	6	are	be	AUX
bam-4840	96	7	encoded	encode	VERB
bam-4840	96	8	by	by	ADP
bam-4840	96	9	a	a	DET
bam-4840	96	10	single	single	ADJ
bam-4840	96	11	gene	gene	NOUN
bam-4840	96	12	;	;	PUNCT
bam-4840	96	13	40	40	NUM
bam-4840	96	14	the	the	DET
bam-4840	96	15	product	product	NOUN
bam-4840	96	16	is	be	AUX
bam-4840	96	17	later	later	ADV
bam-4840	96	18	cleaved	cleaved	ADJ
bam-4840	96	19	but	but	CCONJ
bam-4840	96	20	remains	remain	VERB
bam-4840	96	21	disulfide‐bonded	disulfide‐bonde	VERB
bam-4840	96	22	.	.	PUNCT
bam-4840	97	1	thus	thus	ADV
bam-4840	97	2	the	the	DET
bam-4840	97	3	single‐pass	single‐pass	ADJ
bam-4840	97	4	transmembranal	transmembranal	ADJ
bam-4840	97	5	1	1	NOUN
bam-4840	97	6	subunit	subunit	NOUN
bam-4840	97	7	(	(	PUNCT
bam-4840	97	8	24	24	NUM
bam-4840	97	9	kda	kda	NOUN
bam-4840	97	10	)	)	PUNCT
bam-4840	97	11	must	must	AUX
bam-4840	97	12	be	be	AUX
bam-4840	97	13	at	at	ADP
bam-4840	97	14	the	the	DET
bam-4840	97	15	base	base	NOUN
bam-4840	97	16	of	of	ADP
bam-4840	97	17	the	the	DET
bam-4840	97	18	2	2	ADJ
bam-4840	97	19	subunit	subunit	NOUN
bam-4840	97	20	,	,	PUNCT
bam-4840	97	21	anchoring	anchor	VERB
bam-4840	97	22	it	it	PRON
bam-4840	97	23	to	to	ADP
bam-4840	97	24	the	the	DET
bam-4840	97	25	membrane	membrane	NOUN
bam-4840	97	26	.	.	PUNCT
bam-4840	98	1	1a	1a	NOUN
bam-4840	98	2	subunit	subunit	NOUN
bam-4840	98	3	the	the	DET
bam-4840	98	4	position	position	NOUN
bam-4840	98	5	of	of	ADP
bam-4840	98	6	the	the	DET
bam-4840	98	7	intracellular	intracellular	ADJ
bam-4840	98	8	1a	1a	NOUN
bam-4840	98	9	subunit	subunit	NOUN
bam-4840	98	10	(	(	PUNCT
bam-4840	98	11	56	56	NUM
bam-4840	98	12	kda	kda	NOUN
bam-4840	98	13	)	)	PUNCT
bam-4840	98	14	was	be	AUX
bam-4840	98	15	established	establish	VERB
bam-4840	98	16	by	by	ADP
bam-4840	98	17	identification	identification	NOUN
bam-4840	98	18	of	of	ADP
bam-4840	98	19	the	the	DET
bam-4840	98	20	typical	typical	ADJ
bam-4840	98	21	barrel	barrel	NOUN
bam-4840	98	22	shape	shape	NOUN
bam-4840	98	23	corresponding	correspond	VERB
bam-4840	98	24	to	to	ADP
bam-4840	98	25	yfp	yfp	PROPN
bam-4840	98	26	(	(	PUNCT
bam-4840	98	27	fig	fig	NOUN
bam-4840	98	28	.	.	PUNCT
bam-4840	99	1	2f	2f	NUM
bam-4840	99	2	)	)	PUNCT
bam-4840	99	3	,	,	PUNCT
bam-4840	99	4	engineered	engineer	VERB
bam-4840	99	5	at	at	ADP
bam-4840	99	6	1a	1a	NOUN
bam-4840	99	7	's	's	PART
bam-4840	99	8	n	n	DET
bam-4840	99	9	terminus	terminus	NOUN
bam-4840	99	10	.	.	PUNCT
bam-4840	100	1	25	25	NUM
bam-4840	100	2	this	this	DET
bam-4840	100	3	localization	localization	NOUN
bam-4840	100	4	is	be	AUX
bam-4840	100	5	compatible	compatible	ADJ
bam-4840	100	6	with	with	ADP
bam-4840	100	7	previous	previous	ADJ
bam-4840	100	8	antibody	antibody	NOUN
bam-4840	100	9	labeling	labeling	NOUN
bam-4840	100	10	.	.	PUNCT
bam-4840	101	1	29,30	29,30	NUM
bam-4840	101	2	the	the	DET
bam-4840	101	3	atomic	atomic	ADJ
bam-4840	101	4	structure	structure	NOUN
bam-4840	101	5	of	of	ADP
bam-4840	101	6	the	the	DET
bam-4840	101	7	core	core	NOUN
bam-4840	101	8	region	region	NOUN
bam-4840	101	9	of	of	ADP
bam-4840	101	10	the	the	DET
bam-4840	101	11	2a	2a	NOUN
bam-4840	101	12	isoform	isoform	NOUN
bam-4840	101	13	,	,	PUNCT
bam-4840	101	14	encompassing	encompass	VERB
bam-4840	101	15	the	the	DET
bam-4840	101	16	src	src	NOUN
bam-4840	101	17	homology	homology	NOUN
bam-4840	101	18	3	3	NUM
bam-4840	101	19	(	(	PUNCT
bam-4840	101	20	sh3	sh3	NOUN
bam-4840	101	21	)	)	PUNCT
bam-4840	101	22	domain	domain	NOUN
bam-4840	101	23	and	and	CCONJ
bam-4840	101	24	a	a	DET
bam-4840	101	25	guanylate	guanylate	NOUN
bam-4840	101	26	kinase	kinase	NOUN
bam-4840	101	27	(	(	PUNCT
bam-4840	101	28	gk	gk	PROPN
bam-4840	101	29	)	)	PUNCT
bam-4840	101	30	domain	domain	NOUN
bam-4840	101	31	,	,	PUNCT
bam-4840	101	32	35	35	NUM
bam-4840	101	33	with	with	ADP
bam-4840	101	34	84	84	NUM
bam-4840	101	35	%	%	NOUN
bam-4840	101	36	identity	identity	NOUN
bam-4840	101	37	with	with	ADP
bam-4840	101	38	1a	1a	NOUN
bam-4840	101	39	,	,	PUNCT
bam-4840	101	40	was	be	AUX
bam-4840	101	41	docked	dock	VERB
bam-4840	101	42	into	into	ADP
bam-4840	101	43	the	the	DET
bam-4840	101	44	3d	3d	NOUN
bam-4840	101	45	reconstruction	reconstruction	NOUN
bam-4840	101	46	of	of	ADP
bam-4840	101	47	the	the	DET
bam-4840	101	48	dhpr	dhpr	ADJ
bam-4840	101	49	complex	complex	NOUN
bam-4840	101	50	obtained	obtain	VERB
bam-4840	101	51	by	by	ADP
bam-4840	101	52	tem	tem	PROPN
bam-4840	101	53	taking	take	VERB
bam-4840	101	54	several	several	ADJ
bam-4840	101	55	factors	factor	NOUN
bam-4840	101	56	into	into	ADP
bam-4840	101	57	account	account	NOUN
bam-4840	101	58	.	.	PUNCT
bam-4840	102	1	the	the	DET
bam-4840	102	2	alpha‐binding	alpha‐binde	VERB
bam-4840	102	3	pocket	pocket	NOUN
bam-4840	102	4	of	of	ADP
bam-4840	102	5	the	the	DET
bam-4840	102	6	subunitwhich	subunitwhich	PROPN
bam-4840	102	7	interacts	interact	VERB
bam-4840	102	8	with	with	ADP
bam-4840	102	9	the	the	DET
bam-4840	102	10	aid	aid	NOUN
bam-4840	102	11	binding	bind	VERB
bam-4840	102	12	region	region	NOUN
bam-4840	102	13	within	within	ADP
bam-4840	102	14	the	the	DET
bam-4840	102	15	i‐ii	i‐ii	ADJ
bam-4840	102	16	loop	loop	NOUN
bam-4840	102	17	of1s	of1	NOUN
bam-4840	102	18	,	,	PUNCT
bam-4840	102	19	was	be	AUX
bam-4840	102	20	situated	situate	VERB
bam-4840	102	21	adjacent	adjacent	ADJ
bam-4840	102	22	to	to	ADP
bam-4840	102	23	1s	1s	VERB
bam-4840	102	24	in	in	ADP
bam-4840	102	25	a	a	DET
bam-4840	102	26	position	position	NOUN
bam-4840	102	27	appropriate	appropriate	ADJ
bam-4840	102	28	for	for	SCONJ
bam-4840	102	29	this	this	DET
bam-4840	102	30	inter‐subunit	inter‐subunit	NOUN
bam-4840	102	31	interaction	interaction	NOUN
bam-4840	102	32	to	to	PART
bam-4840	102	33	occur	occur	VERB
bam-4840	102	34	.	.	PUNCT
bam-4840	103	1	the	the	DET
bam-4840	103	2	sh3	sh3	PROPN
bam-4840	103	3	in	in	ADP
bam-4840	103	4	the	the	DET
bam-4840	103	5	n	n	CCONJ
bam-4840	103	6	'	'	PUNCT
bam-4840	103	7	region	region	NOUN
bam-4840	103	8	of	of	ADP
bam-4840	103	9	the	the	DET
bam-4840	103	10	subunit	subunit	PROPN
bam-4840	103	11	was	be	AUX
bam-4840	103	12	placed	place	VERB
bam-4840	103	13	adjacent	adjacent	ADJ
bam-4840	103	14	to	to	ADP
bam-4840	103	15	the	the	DET
bam-4840	103	16	identifiable	identifiable	ADJ
bam-4840	103	17	yfp	yfp	NOUN
bam-4840	103	18	engineered	engineer	VERB
bam-4840	103	19	in	in	ADP
bam-4840	103	20	the	the	DET
bam-4840	103	21	n	n	CCONJ
bam-4840	103	22	’	'	PUNCT
bam-4840	103	23	region	region	NOUN
bam-4840	103	24	.	.	PUNCT
bam-4840	104	1	finally	finally	ADV
bam-4840	104	2	,	,	PUNCT
bam-4840	104	3	the	the	DET
bam-4840	104	4	two	two	NUM
bam-4840	104	5	prominent	prominent	ADJ
bam-4840	104	6	lobes	lobe	NOUN
bam-4840	104	7	of	of	ADP
bam-4840	104	8	the	the	DET
bam-4840	104	9	gk	gk	PROPN
bam-4840	104	10	domain	domain	NOUN
bam-4840	104	11	were	be	AUX
bam-4840	104	12	fit	fit	ADJ
bam-4840	104	13	with	with	ADP
bam-4840	104	14	the	the	DET
bam-4840	104	15	two	two	NUM
bam-4840	104	16	outward	outward	ADJ
bam-4840	104	17	spikes	spike	NOUN
bam-4840	104	18	in	in	ADP
bam-4840	104	19	the	the	DET
bam-4840	104	20	3d	3d	NOUN
bam-4840	104	21	volume	volume	NOUN
bam-4840	104	22	of	of	ADP
bam-4840	104	23	dhpr	dhpr	ADJ
bam-4840	104	24	25	25	NUM
bam-4840	104	25	(	(	PUNCT
bam-4840	104	26	fig	fig	NOUN
bam-4840	104	27	.	.	PUNCT
bam-4840	105	1	2e‐f	2e‐f	NOUN
bam-4840	105	2	)	)	PUNCT
bam-4840	105	3	.	.	PUNCT
bam-4840	106	1	in	in	ADP
bam-4840	106	2	addition	addition	NOUN
bam-4840	106	3	that	that	SCONJ
bam-4840	106	4	the	the	DET
bam-4840	106	5	choice	choice	NOUN
bam-4840	106	6	of	of	ADP
bam-4840	106	7	location	location	NOUN
bam-4840	106	8	and	and	CCONJ
bam-4840	106	9	orientation	orientation	NOUN
bam-4840	106	10	satisfy	satisfy	VERB
bam-4840	106	11	all	all	DET
bam-4840	106	12	the	the	DET
bam-4840	106	13	above	above	ADJ
bam-4840	106	14	conditions	condition	NOUN
bam-4840	106	15	,	,	PUNCT
bam-4840	106	16	further	further	ADJ
bam-4840	106	17	confidence	confidence	NOUN
bam-4840	106	18	in	in	ADP
bam-4840	106	19	this	this	DET
bam-4840	106	20	model	model	NOUN
bam-4840	106	21	comes	come	VERB
bam-4840	106	22	from	from	ADP
bam-4840	106	23	the	the	DET
bam-4840	106	24	fact	fact	NOUN
bam-4840	106	25	that	that	SCONJ
bam-4840	106	26	the	the	DET
bam-4840	106	27	docking	docking	NOUN
bam-4840	106	28	is	be	AUX
bam-4840	106	29	close	close	ADV
bam-4840	106	30	fitting	fitting	ADJ
bam-4840	106	31	when	when	SCONJ
bam-4840	106	32	seen	see	VERB
bam-4840	106	33	from	from	ADP
bam-4840	106	34	all	all	DET
bam-4840	106	35	directions	direction	NOUN
bam-4840	106	36	(	(	PUNCT
bam-4840	106	37	see	see	VERB
bam-4840	106	38	supplemental	supplemental	ADJ
bam-4840	106	39	movie	movie	NOUN
bam-4840	106	40	)	)	PUNCT
bam-4840	106	41	fig	fig	NOUN
bam-4840	106	42	3	3	NUM
bam-4840	106	43	.	.	NUM
bam-4840	106	44	approximate	approximate	ADJ
bam-4840	106	45	quaternary	quaternary	ADJ
bam-4840	106	46	arrangement	arrangement	NOUN
bam-4840	106	47	of	of	ADP
bam-4840	106	48	the	the	DET
bam-4840	106	49	dhpr	dhpr	NOUN
bam-4840	106	50	and	and	CCONJ
bam-4840	106	51	the	the	DET
bam-4840	106	52	ryr1	ryr1	NOUN
bam-4840	106	53	in	in	ADP
bam-4840	106	54	the	the	DET
bam-4840	106	55	triad	triad	ADJ
bam-4840	106	56	junction	junction	NOUN
bam-4840	106	57	.	.	PUNCT
bam-4840	107	1	in	in	ADP
bam-4840	107	2	this	this	DET
bam-4840	107	3	disposition	disposition	NOUN
bam-4840	107	4	,	,	PUNCT
bam-4840	107	5	the	the	DET
bam-4840	107	6	ii‐iii	ii‐iii	PROPN
bam-4840	107	7	loop	loop	NOUN
bam-4840	107	8	and	and	CCONJ
bam-4840	107	9	the	the	DET
bam-4840	107	10	subunit	subunit	NOUN
bam-4840	107	11	of	of	ADP
bam-4840	107	12	the	the	DET
bam-4840	107	13	dhpr	dhpr	NOUN
bam-4840	107	14	,	,	PUNCT
bam-4840	107	15	domains	domain	NOUN
bam-4840	107	16	important	important	ADJ
bam-4840	107	17	for	for	ADP
bam-4840	107	18	ec	ec	PROPN
bam-4840	107	19	coupling	coupling	NOUN
bam-4840	107	20	,	,	PUNCT
bam-4840	107	21	are	be	AUX
bam-4840	107	22	proximal	proximal	ADJ
bam-4840	107	23	to	to	ADP
bam-4840	107	24	the	the	DET
bam-4840	107	25	ryr1	ryr1	NOUN
bam-4840	107	26	.	.	PUNCT
bam-4840	108	1	in	in	ADP
bam-4840	108	2	addition	addition	NOUN
bam-4840	108	3	,	,	PUNCT
bam-4840	108	4	a	a	NOUN
bam-4840	108	5	is	be	AUX
bam-4840	108	6	located	locate	VERB
bam-4840	108	7	just	just	ADV
bam-4840	108	8	under	under	ADP
bam-4840	108	9	the	the	DET
bam-4840	108	10	membrane	membrane	NOUN
bam-4840	108	11	and	and	CCONJ
bam-4840	108	12	besides	besides	SCONJ
bam-4840	108	13	1s	1	NOUN
bam-4840	108	14	,	,	PUNCT
bam-4840	108	15	in	in	ADP
bam-4840	108	16	agreement	agreement	NOUN
bam-4840	108	17	with	with	ADP
bam-4840	108	18	its	its	PRON
bam-4840	108	19	role	role	NOUN
bam-4840	108	20	of	of	ADP
bam-4840	108	21	trafficking	traffic	VERB
bam-4840	108	22	1s	1	NOUN
bam-4840	108	23	to	to	ADP
bam-4840	108	24	the	the	DET
bam-4840	108	25	membrane	membrane	NOUN
bam-4840	108	26	in	in	ADP
bam-4840	108	27	the	the	DET
bam-4840	108	28	vicinity	vicinity	NOUN
bam-4840	108	29	of	of	ADP
bam-4840	108	30	ryr1	ryr1	NOUN
bam-4840	108	31	.	.	PUNCT
bam-4840	109	1	the	the	DET
bam-4840	109	2	tt	tt	PROPN
bam-4840	109	3	and	and	CCONJ
bam-4840	109	4	sr	sr	PROPN
bam-4840	109	5	membrane	membrane	NOUN
bam-4840	109	6	boundaries	boundary	NOUN
bam-4840	109	7	are	be	AUX
bam-4840	109	8	indicated	indicate	VERB
bam-4840	109	9	.	.	PUNCT
bam-4840	110	1	the	the	DET
bam-4840	110	2	two	two	NUM
bam-4840	110	3	proteins	protein	NOUN
bam-4840	110	4	are	be	AUX
bam-4840	110	5	represented	represent	VERB
bam-4840	110	6	at	at	ADP
bam-4840	110	7	the	the	DET
bam-4840	110	8	same	same	ADJ
bam-4840	110	9	scale	scale	NOUN
bam-4840	110	10	.	.	PUNCT
bam-4840	111	1	scale	scale	NOUN
bam-4840	111	2	bar	bar	NOUN
bam-4840	111	3	,	,	PUNCT
bam-4840	111	4	10	10	NUM
bam-4840	111	5	nm	nm	NOUN
bam-4840	111	6	.	.	PUNCT
bam-4840	112	1	3d	3d	NUM
bam-4840	112	2	structure	structure	NOUN
bam-4840	112	3	of	of	ADP
bam-4840	112	4	muscle	muscle	NOUN
bam-4840	112	5	dihydropyridine	dihydropyridine	NOUN
bam-4840	112	6	receptor	receptor	PROPN
bam-4840	112	7	eur	eur	PROPN
bam-4840	112	8	j	j	PROPN
bam-4840	112	9	transl	transl	PROPN
bam-4840	112	10	myol	myol	PROPN
bam-4840	112	11	basic	basic	ADJ
bam-4840	112	12	appl	appl	NOUN
bam-4840	112	13	myol	myol	NOUN
bam-4840	112	14	2015	2015	NUM
bam-4840	112	15	;	;	PUNCT
bam-4840	112	16	25	25	NUM
bam-4840	112	17	(	(	PUNCT
bam-4840	112	18	1	1	NUM
bam-4840	112	19	):	):	PUNCT
bam-4840	112	20	27	27	NUM
bam-4840	112	21	-	-	SYM
bam-4840	112	22	33	33	NUM
bam-4840	112	23	31	31	NUM
bam-4840	112	24	subunit	subunit	PROPN
bam-4840	112	25	the	the	DET
bam-4840	112	26	subunit	subunit	PROPN
bam-4840	112	27	(	(	PUNCT
bam-4840	112	28	34	34	NUM
bam-4840	112	29	kda	kda	NOUN
bam-4840	112	30	)	)	PUNCT
bam-4840	112	31	,	,	PUNCT
bam-4840	112	32	with	with	ADP
bam-4840	112	33	four	four	NUM
bam-4840	112	34	transmembrane	transmembrane	ADJ
bam-4840	112	35	domains	domain	NOUN
bam-4840	112	36	,	,	PUNCT
bam-4840	112	37	must	must	AUX
bam-4840	112	38	be	be	AUX
bam-4840	112	39	in	in	ADP
bam-4840	112	40	one	one	NUM
bam-4840	112	41	of	of	ADP
bam-4840	112	42	the	the	DET
bam-4840	112	43	empty	empty	ADJ
bam-4840	112	44	spaces	space	NOUN
bam-4840	112	45	near	near	ADP
bam-4840	112	46	1s	1	NOUN
bam-4840	112	47	,	,	PUNCT
bam-4840	112	48	as	as	SCONJ
bam-4840	112	49	it	it	PRON
bam-4840	112	50	is	be	AUX
bam-4840	112	51	known	know	VERB
bam-4840	112	52	to	to	PART
bam-4840	112	53	interact	interact	VERB
bam-4840	112	54	with	with	ADP
bam-4840	112	55	this	this	DET
bam-4840	112	56	subunit	subunit	NOUN
bam-4840	112	57	.	.	PUNCT
bam-4840	113	1	41	41	NUM
bam-4840	113	2	in	in	ADP
bam-4840	113	3	the	the	DET
bam-4840	113	4	context	context	NOUN
bam-4840	113	5	of	of	ADP
bam-4840	113	6	the	the	DET
bam-4840	113	7	quaternary	quaternary	ADJ
bam-4840	113	8	interactions	interaction	NOUN
bam-4840	113	9	with	with	ADP
bam-4840	113	10	the	the	DET
bam-4840	113	11	ryr1	ryr1	NOUN
bam-4840	113	12	,	,	PUNCT
bam-4840	113	13	the	the	DET
bam-4840	113	14	dhpr	dhpr	NOUN
bam-4840	113	15	would	would	AUX
bam-4840	113	16	be	be	AUX
bam-4840	113	17	facing	face	VERB
bam-4840	113	18	the	the	DET
bam-4840	113	19	ryr1	ryr1	NOUN
bam-4840	113	20	across	across	ADP
bam-4840	113	21	the	the	DET
bam-4840	113	22	junctional	junctional	ADJ
bam-4840	113	23	triadic	triadic	ADJ
bam-4840	113	24	cleft	cleft	NOUN
bam-4840	113	25	.	.	PUNCT
bam-4840	114	1	on	on	ADP
bam-4840	114	2	the	the	DET
bam-4840	114	3	sr	sr	PROPN
bam-4840	114	4	side	side	NOUN
bam-4840	114	5	,	,	PUNCT
bam-4840	114	6	the	the	DET
bam-4840	114	7	ryr1	ryr1	NOUN
bam-4840	114	8	's	's	PART
bam-4840	114	9	cytoplasmic	cytoplasmic	ADJ
bam-4840	114	10	domain	domain	NOUN
bam-4840	114	11	(	(	PUNCT
bam-4840	114	12	i.e.	i.e.	X
bam-4840	114	13	the	the	DET
bam-4840	114	14	foot	foot	NOUN
bam-4840	114	15	structure	structure	NOUN
bam-4840	114	16	)	)	PUNCT
bam-4840	114	17	occupies	occupy	VERB
bam-4840	114	18	120	120	NUM
bam-4840	114	19	å	å	PROPN
bam-4840	114	20	of	of	ADP
bam-4840	114	21	the	the	DET
bam-4840	114	22	cleft	cleft	NOUN
bam-4840	114	23	,	,	PUNCT
bam-4840	114	24	practically	practically	ADV
bam-4840	114	25	bridging	bridge	VERB
bam-4840	114	26	the	the	DET
bam-4840	114	27	space	space	NOUN
bam-4840	114	28	between	between	ADP
bam-4840	114	29	the	the	DET
bam-4840	114	30	two	two	NUM
bam-4840	114	31	membranes	membrane	NOUN
bam-4840	114	32	.	.	PUNCT
bam-4840	115	1	on	on	ADP
bam-4840	115	2	the	the	DET
bam-4840	115	3	tt	tt	PROPN
bam-4840	115	4	side	side	NOUN
bam-4840	115	5	,	,	PUNCT
bam-4840	115	6	the	the	DET
bam-4840	115	7	ii‐iii	ii‐iii	PROPN
bam-4840	115	8	loop	loop	NOUN
bam-4840	115	9	of	of	ADP
bam-4840	115	10	cav1.1	cav1.1	NOUN
bam-4840	115	11	is	be	AUX
bam-4840	115	12	sandwiched	sandwich	VERB
bam-4840	115	13	between	between	ADP
bam-4840	115	14	the	the	DET
bam-4840	115	15	rest	rest	NOUN
bam-4840	115	16	of	of	ADP
bam-4840	115	17	the	the	DET
bam-4840	115	18	dhpr	dhpr	NOUN
bam-4840	115	19	and	and	CCONJ
bam-4840	115	20	the	the	DET
bam-4840	115	21	ryr1	ryr1	NOUN
bam-4840	115	22	,	,	PUNCT
bam-4840	115	23	in	in	ADP
bam-4840	115	24	full	full	ADJ
bam-4840	115	25	agreement	agreement	NOUN
bam-4840	115	26	with	with	ADP
bam-4840	115	27	its	its	PRON
bam-4840	115	28	vital	vital	ADJ
bam-4840	115	29	role	role	NOUN
bam-4840	115	30	in	in	ADP
bam-4840	115	31	ec	ec	PROPN
bam-4840	115	32	coupling	coupling	NOUN
bam-4840	115	33	.	.	PUNCT
bam-4840	116	1	17	17	NUM
bam-4840	116	2	the	the	DET
bam-4840	116	3	1a	1a	NOUN
bam-4840	116	4	subunit	subunit	NOUN
bam-4840	116	5	location	location	NOUN
bam-4840	116	6	,	,	PUNCT
bam-4840	116	7	adjacent	adjacent	ADJ
bam-4840	116	8	to	to	ADP
bam-4840	116	9	cav1.1	cav1.1	NOUN
bam-4840	116	10	and	and	CCONJ
bam-4840	116	11	sandwiched	sandwich	VERB
bam-4840	116	12	between	between	ADP
bam-4840	116	13	the	the	DET
bam-4840	116	14	tt	tt	PROPN
bam-4840	116	15	membrane	membrane	NOUN
bam-4840	116	16	and	and	CCONJ
bam-4840	116	17	the	the	DET
bam-4840	116	18	ryr1	ryr1	NOUN
bam-4840	116	19	,	,	PUNCT
bam-4840	116	20	with	with	ADP
bam-4840	116	21	potentially	potentially	ADV
bam-4840	116	22	large	large	ADJ
bam-4840	116	23	areas	area	NOUN
bam-4840	116	24	of	of	ADP
bam-4840	116	25	interface	interface	NOUN
bam-4840	116	26	,	,	PUNCT
bam-4840	116	27	is	be	AUX
bam-4840	116	28	compatible	compatible	ADJ
bam-4840	116	29	with	with	ADP
bam-4840	116	30	its	its	PRON
bam-4840	116	31	functions	function	NOUN
bam-4840	116	32	of	of	ADP
bam-4840	116	33	trafficking	traffic	VERB
bam-4840	116	34	cav1.1	cav1.1	NOUN
bam-4840	116	35	to	to	ADP
bam-4840	116	36	the	the	DET
bam-4840	116	37	membrane	membrane	NOUN
bam-4840	116	38	42	42	NUM
bam-4840	116	39	and	and	CCONJ
bam-4840	116	40	control	control	NOUN
bam-4840	116	41	of	of	ADP
bam-4840	116	42	ec	ec	PROPN
bam-4840	116	43	coupling	coupling	PROPN
bam-4840	116	44	,	,	PUNCT
bam-4840	116	45	19	19	NUM
bam-4840	116	46	possibly	possibly	ADV
bam-4840	116	47	indirectly	indirectly	ADV
bam-4840	116	48	by	by	ADP
bam-4840	116	49	determining	determine	VERB
bam-4840	116	50	the	the	DET
bam-4840	116	51	dhpr‐ryr1	dhpr‐ryr1	PROPN
bam-4840	116	52	association	association	NOUN
bam-4840	116	53	.	.	PUNCT
bam-4840	117	1	21	21	NUM
bam-4840	117	2	figure	figure	NOUN
bam-4840	117	3	3	3	NUM
bam-4840	117	4	summarizes	summarize	NOUN
bam-4840	117	5	how	how	SCONJ
bam-4840	117	6	the	the	DET
bam-4840	117	7	ryr1	ryr1	NOUN
bam-4840	117	8	,	,	PUNCT
bam-4840	117	9	the	the	DET
bam-4840	117	10	dhpr	dhpr	NOUN
bam-4840	117	11	and	and	CCONJ
bam-4840	117	12	its	its	PRON
bam-4840	117	13	more	more	ADV
bam-4840	117	14	important	important	ADJ
bam-4840	117	15	ec	ec	PROPN
bam-4840	117	16	coupling	couple	VERB
bam-4840	117	17	domains	domain	NOUN
bam-4840	117	18	would	would	AUX
bam-4840	117	19	be	be	AUX
bam-4840	117	20	located	locate	VERB
bam-4840	117	21	relative	relative	ADJ
bam-4840	117	22	to	to	ADP
bam-4840	117	23	each	each	DET
bam-4840	117	24	other	other	ADJ
bam-4840	117	25	in	in	ADP
bam-4840	117	26	the	the	DET
bam-4840	117	27	context	context	NOUN
bam-4840	117	28	of	of	ADP
bam-4840	117	29	the	the	DET
bam-4840	117	30	triad	triad	ADJ
bam-4840	117	31	junction	junction	NOUN
bam-4840	117	32	.	.	PUNCT
bam-4840	118	1	it	it	PRON
bam-4840	118	2	is	be	AUX
bam-4840	118	3	expected	expect	VERB
bam-4840	118	4	that	that	SCONJ
bam-4840	118	5	higher	high	ADJ
bam-4840	118	6	resolution	resolution	NOUN
bam-4840	118	7	structures	structure	NOUN
bam-4840	118	8	,	,	PUNCT
bam-4840	118	9	combined	combine	VERB
bam-4840	118	10	with	with	ADP
bam-4840	118	11	functional	functional	ADJ
bam-4840	118	12	studies	study	NOUN
bam-4840	118	13	and	and	CCONJ
bam-4840	118	14	high	high	ADJ
bam-4840	118	15	electron	electron	NOUN
bam-4840	118	16	tomography	tomography	NOUN
bam-4840	118	17	,	,	PUNCT
bam-4840	118	18	will	will	AUX
bam-4840	118	19	,	,	PUNCT
bam-4840	118	20	in	in	ADP
bam-4840	118	21	the	the	DET
bam-4840	118	22	future	future	NOUN
bam-4840	118	23	,	,	PUNCT
bam-4840	118	24	provide	provide	VERB
bam-4840	118	25	a	a	DET
bam-4840	118	26	picture	picture	NOUN
bam-4840	118	27	of	of	ADP
bam-4840	118	28	the	the	DET
bam-4840	118	29	quaternary	quaternary	ADJ
bam-4840	118	30	assembly	assembly	NOUN
bam-4840	118	31	of	of	ADP
bam-4840	118	32	dhpr	dhpr	NOUN
bam-4840	118	33	and	and	CCONJ
bam-4840	118	34	ryr1	ryr1	NOUN
bam-4840	118	35	at	at	ADP
bam-4840	118	36	the	the	DET
bam-4840	118	37	atomic	atomic	ADJ
bam-4840	118	38	level	level	NOUN
bam-4840	118	39	,	,	PUNCT
bam-4840	118	40	and	and	CCONJ
bam-4840	118	41	enable	enable	VERB
bam-4840	118	42	a	a	DET
bam-4840	118	43	more	more	ADV
bam-4840	118	44	thorough	thorough	ADJ
bam-4840	118	45	understanding	understanding	NOUN
bam-4840	118	46	of	of	ADP
bam-4840	118	47	the	the	DET
bam-4840	118	48	ec	ec	PROPN
bam-4840	118	49	coupling	coupling	NOUN
bam-4840	118	50	mechanism	mechanism	NOUN
bam-4840	118	51	at	at	ADP
bam-4840	118	52	the	the	DET
bam-4840	118	53	molecular	molecular	ADJ
bam-4840	118	54	level	level	NOUN
bam-4840	118	55	.	.	PUNCT
bam-4840	119	1	recent	recent	ADJ
bam-4840	119	2	advancements	advancement	NOUN
bam-4840	119	3	in	in	ADP
bam-4840	119	4	membrane	membrane	NOUN
bam-4840	119	5	protein	protein	NOUN
bam-4840	119	6	stabilization	stabilization	NOUN
bam-4840	119	7	(	(	PUNCT
bam-4840	119	8	i.e.	i.e.	X
bam-4840	119	9	using	use	VERB
bam-4840	119	10	lipid	lipid	NOUN
bam-4840	119	11	mimics	mimic	NOUN
bam-4840	119	12	or	or	CCONJ
bam-4840	119	13	nanodisks	nanodisk	NOUN
bam-4840	119	14	)	)	PUNCT
bam-4840	119	15	and	and	CCONJ
bam-4840	119	16	in	in	ADP
bam-4840	119	17	tem	tem	PROPN
bam-4840	119	18	(	(	PUNCT
bam-4840	119	19	most	most	ADV
bam-4840	119	20	notably	notably	ADV
bam-4840	119	21	the	the	DET
bam-4840	119	22	installation	installation	NOUN
bam-4840	119	23	of	of	ADP
bam-4840	119	24	direct	direct	ADJ
bam-4840	119	25	electron	electron	NOUN
bam-4840	119	26	detectors	detector	NOUN
bam-4840	119	27	)	)	PUNCT
bam-4840	119	28	should	should	AUX
bam-4840	119	29	help	help	VERB
bam-4840	119	30	in	in	ADP
bam-4840	119	31	the	the	DET
bam-4840	119	32	single‐particle	single‐particle	NOUN
bam-4840	119	33	3d	3d	NUM
bam-4840	119	34	structural	structural	ADJ
bam-4840	119	35	determination	determination	NOUN
bam-4840	119	36	of	of	ADP
bam-4840	119	37	the	the	DET
bam-4840	119	38	dhpr	dhpr	NOUN
bam-4840	119	39	and	and	CCONJ
bam-4840	119	40	ryr1	ryr1	NOUN
bam-4840	119	41	at	at	ADP
bam-4840	119	42	much	much	ADV
bam-4840	119	43	higher	high	ADJ
bam-4840	119	44	resolution	resolution	NOUN
bam-4840	119	45	.	.	PUNCT
bam-4840	120	1	43	43	NUM
bam-4840	120	2	note	note	NOUN
bam-4840	120	3	added	add	VERB
bam-4840	120	4	in	in	ADP
bam-4840	120	5	proof	proof	NOUN
bam-4840	120	6	while	while	SCONJ
bam-4840	120	7	this	this	DET
bam-4840	120	8	paper	paper	NOUN
bam-4840	120	9	was	be	AUX
bam-4840	120	10	in	in	ADP
bam-4840	120	11	press	press	NOUN
bam-4840	120	12	,	,	PUNCT
bam-4840	120	13	the	the	DET
bam-4840	120	14	near	near	ADJ
bam-4840	120	15	-	-	PUNCT
bam-4840	120	16	atomic	atomic	ADJ
bam-4840	120	17	structure	structure	NOUN
bam-4840	120	18	of	of	ADP
bam-4840	120	19	ryr1	ryr1	NOUN
bam-4840	120	20	was	be	AUX
bam-4840	120	21	solved	solve	VERB
bam-4840	120	22	at	at	ADP
bam-4840	120	23	3.8	3.8	NUM
bam-4840	120	24	å	å	NOUN
bam-4840	120	25	by	by	ADP
bam-4840	120	26	cryoem	cryoem	NOUN
bam-4840	120	27	.	.	PUNCT
bam-4840	121	1	44	44	NUM
bam-4840	121	2	acknowledgement	acknowledgement	NOUN
bam-4840	121	3	this	this	DET
bam-4840	121	4	work	work	NOUN
bam-4840	121	5	was	be	AUX
bam-4840	121	6	supported	support	VERB
bam-4840	121	7	by	by	ADP
bam-4840	121	8	american	american	ADJ
bam-4840	121	9	heart	heart	PROPN
bam-4840	121	10	association	association	PROPN
bam-4840	121	11	grant	grant	PROPN
bam-4840	121	12	14grnt19660003	14grnt19660003	PROPN
bam-4840	121	13	.	.	PUNCT
bam-4840	122	1	corresponding	correspond	VERB
bam-4840	122	2	author	author	NOUN
bam-4840	122	3	montserrat	montserrat	PROPN
bam-4840	122	4	samsó	samsó	PROPN
bam-4840	122	5	.	.	PUNCT
bam-4840	123	1	department	department	PROPN
bam-4840	123	2	of	of	ADP
bam-4840	123	3	physiology	physiology	NOUN
bam-4840	123	4	and	and	CCONJ
bam-4840	123	5	biophysics	biophysic	NOUN
bam-4840	123	6	,	,	PUNCT
bam-4840	123	7	1101	1101	NUM
bam-4840	123	8	e.	e.	PROPN
bam-4840	123	9	marshall	marshall	PROPN
bam-4840	123	10	st	st	PROPN
bam-4840	123	11	.	.	PROPN
bam-4840	123	12	,	,	PUNCT
bam-4840	123	13	room	room	NOUN
bam-4840	123	14	3‐009	3‐009	NUM
bam-4840	123	15	,	,	PUNCT
bam-4840	123	16	richmond	richmond	PROPN
bam-4840	123	17	,	,	PUNCT
bam-4840	123	18	va	va	PROPN
bam-4840	123	19	23298	23298	NUM
bam-4840	123	20	,	,	PUNCT
bam-4840	123	21	u.s.a	u.s.a	PROPN
bam-4840	123	22	.	.	PUNCT
bam-4840	123	23	telephone	telephone	NOUN
bam-4840	123	24	:	:	PUNCT
bam-4840	123	25	(	(	PUNCT
bam-4840	123	26	804	804	NUM
bam-4840	123	27	)	)	PUNCT
bam-4840	123	28	828‐8728	828‐8728	NUM
bam-4840	123	29	;	;	PUNCT
bam-4840	123	30	fax	fax	NOUN
bam-4840	123	31	:	:	PUNCT
bam-4840	123	32	(	(	PUNCT
bam-4840	123	33	804	804	NUM
bam-4840	123	34	)	)	PUNCT
bam-4840	123	35	828‐9492	828‐9492	NUM
bam-4840	123	36	e‐mail	e‐mail	PUNCT
bam-4840	123	37	address	address	NOUN
bam-4840	123	38	:	:	PUNCT
bam-4840	123	39	msamso@vcu.edu	msamso@vcu.edu	VERB
bam-4840	123	40	references	reference	NOUN
bam-4840	123	41	1	1	NUM
bam-4840	123	42	.	.	PUNCT
bam-4840	124	1	flucher	flucher	PROPN
bam-4840	124	2	be	be	AUX
bam-4840	124	3	.	.	PUNCT
bam-4840	125	1	structural	structural	ADJ
bam-4840	125	2	analysis	analysis	NOUN
bam-4840	125	3	of	of	ADP
bam-4840	125	4	muscle	muscle	NOUN
bam-4840	125	5	development	development	NOUN
bam-4840	125	6	:	:	PUNCT
bam-4840	125	7	transverse	transverse	NOUN
bam-4840	125	8	tubules	tubule	NOUN
bam-4840	125	9	,	,	PUNCT
bam-4840	125	10	sarcoplasmic	sarcoplasmic	NOUN
bam-4840	125	11	reticulum	reticulum	NOUN
bam-4840	125	12	and	and	CCONJ
bam-4840	125	13	the	the	DET
bam-4840	125	14	triad	triad	PROPN
bam-4840	125	15	.	.	PUNCT
bam-4840	126	1	dev	dev	PROPN
bam-4840	126	2	biol	biol	PROPN
bam-4840	126	3	1992;154:245‐60	1992;154:245‐60	NUM
bam-4840	126	4	.	.	PUNCT
bam-4840	127	1	2	2	NUM
bam-4840	127	2	.	.	X
bam-4840	127	3	schneider	schneider	PROPN
bam-4840	127	4	mf	mf	PROPN
bam-4840	127	5	.	.	PROPN
bam-4840	127	6	membrane	membrane	NOUN
bam-4840	127	7	charge	charge	NOUN
bam-4840	127	8	movement	movement	NOUN
bam-4840	127	9	and	and	CCONJ
bam-4840	127	10	depolarization‐contraction	depolarization‐contraction	NOUN
bam-4840	127	11	coupling	coupling	NOUN
bam-4840	127	12	.	.	PUNCT
bam-4840	128	1	annu	annu	PROPN
bam-4840	128	2	rev	rev	PROPN
bam-4840	128	3	physiol	physiol	PROPN
bam-4840	128	4	1981;43:507‐7	1981;43:507‐7	PROPN
bam-4840	128	5	.	.	PROPN
bam-4840	129	1	3	3	NUM
bam-4840	129	2	.	.	NOUN
bam-4840	129	3	eltit	eltit	PROPN
bam-4840	129	4	jm	jm	PROPN
bam-4840	129	5	,	,	PUNCT
bam-4840	129	6	li	li	PROPN
bam-4840	129	7	h	h	PROPN
bam-4840	129	8	,	,	PUNCT
bam-4840	129	9	ward	ward	NOUN
bam-4840	129	10	cw	cw	NOUN
bam-4840	129	11	,	,	PUNCT
bam-4840	129	12	et	et	PROPN
bam-4840	129	13	al	al	PROPN
bam-4840	129	14	.	.	PROPN
bam-4840	130	1	orthograde	orthograde	ADJ
bam-4840	130	2	dihydropyridine	dihydropyridine	NOUN
bam-4840	130	3	receptor	receptor	NOUN
bam-4840	130	4	signal	signal	NOUN
bam-4840	130	5	regulates	regulate	VERB
bam-4840	130	6	ryanodine	ryanodine	NOUN
bam-4840	130	7	receptor	receptor	NOUN
bam-4840	130	8	passive	passive	ADJ
bam-4840	130	9	leak	leak	NOUN
bam-4840	130	10	.	.	PUNCT
bam-4840	131	1	proc	proc	PROPN
bam-4840	131	2	natl	natl	PROPN
bam-4840	131	3	acad	acad	PROPN
bam-4840	131	4	sci	sci	PROPN
bam-4840	131	5	u	u	PROPN
bam-4840	131	6	s	s	PROPN
bam-4840	131	7	a	a	DET
bam-4840	131	8	2011;108:7046‐51	2011;108:7046‐51	NUM
bam-4840	131	9	.	.	NOUN
bam-4840	131	10	4	4	NUM
bam-4840	131	11	.	.	X
bam-4840	132	1	pirone	pirone	PROPN
bam-4840	132	2	a	a	PRON
bam-4840	132	3	,	,	PUNCT
bam-4840	132	4	schredelseker	schredelseker	NOUN
bam-4840	132	5	j	j	PROPN
bam-4840	132	6	,	,	PUNCT
bam-4840	132	7	tuluc	tuluc	PROPN
bam-4840	132	8	p	p	X
bam-4840	132	9	,	,	PUNCT
bam-4840	132	10	et	et	PROPN
bam-4840	132	11	al	al	PROPN
bam-4840	132	12	.	.	PUNCT
bam-4840	132	13	identification	identification	NOUN
bam-4840	132	14	and	and	CCONJ
bam-4840	132	15	functional	functional	ADJ
bam-4840	132	16	characterization	characterization	NOUN
bam-4840	132	17	of	of	ADP
bam-4840	132	18	malignant	malignant	ADJ
bam-4840	132	19	hyperthermia	hyperthermia	NOUN
bam-4840	132	20	mutation	mutation	NOUN
bam-4840	132	21	t1354s	t1354s	NOUN
bam-4840	132	22	in	in	ADP
bam-4840	132	23	the	the	DET
bam-4840	132	24	outer	outer	ADJ
bam-4840	132	25	pore	pore	NOUN
bam-4840	132	26	of	of	ADP
bam-4840	132	27	the	the	DET
bam-4840	132	28	cavalpha1s‐subunit	cavalpha1s‐subunit	PROPN
bam-4840	132	29	.	.	PROPN
bam-4840	132	30	am	be	AUX
bam-4840	132	31	j	j	PROPN
bam-4840	132	32	physiol	physiol	PROPN
bam-4840	132	33	cell	cell	PROPN
bam-4840	132	34	physiol	physiol	PROPN
bam-4840	132	35	2010;299	2010;299	NUM
bam-4840	132	36	:	:	PUNCT
bam-4840	132	37	c1345‐54	c1345‐54	NOUN
bam-4840	132	38	.	.	PROPN
bam-4840	133	1	5	5	NUM
bam-4840	133	2	.	.	X
bam-4840	133	3	weiss	weiss	PROPN
bam-4840	133	4	rg	rg	PROPN
bam-4840	133	5	,	,	PUNCT
bam-4840	133	6	o'connell	o'connell	PROPN
bam-4840	133	7	km	km	PROPN
bam-4840	133	8	,	,	PUNCT
bam-4840	133	9	flucher	flucher	NOUN
bam-4840	133	10	be	be	AUX
bam-4840	133	11	,	,	PUNCT
bam-4840	133	12	et	et	PROPN
bam-4840	133	13	al	al	PROPN
bam-4840	133	14	.	.	PUNCT
bam-4840	134	1	functional	functional	ADJ
bam-4840	134	2	analysis	analysis	NOUN
bam-4840	134	3	of	of	ADP
bam-4840	134	4	the	the	DET
bam-4840	134	5	r1086h	r1086h	ADJ
bam-4840	134	6	malignant	malignant	ADJ
bam-4840	134	7	hyperthermia	hyperthermia	NOUN
bam-4840	134	8	mutation	mutation	NOUN
bam-4840	134	9	in	in	ADP
bam-4840	134	10	the	the	DET
bam-4840	134	11	dhpr	dhpr	NOUN
bam-4840	134	12	reveals	reveal	VERB
bam-4840	134	13	an	an	DET
bam-4840	134	14	unexpected	unexpected	ADJ
bam-4840	134	15	influence	influence	NOUN
bam-4840	134	16	of	of	ADP
bam-4840	134	17	the	the	DET
bam-4840	134	18	iii‐iv	iii‐iv	ADJ
bam-4840	134	19	loop	loop	NOUN
bam-4840	134	20	on	on	ADP
bam-4840	134	21	skeletal	skeletal	ADJ
bam-4840	134	22	muscle	muscle	NOUN
bam-4840	134	23	ec	ec	PROPN
bam-4840	134	24	coupling	coupling	NOUN
bam-4840	134	25	.	.	PUNCT
bam-4840	135	1	am	be	AUX
bam-4840	135	2	j	j	PROPN
bam-4840	135	3	physiol	physiol	PROPN
bam-4840	135	4	cell	cell	PROPN
bam-4840	135	5	physiol	physiol	PROPN
bam-4840	135	6	2004;287	2004;287	NUM
bam-4840	135	7	:	:	PUNCT
bam-4840	135	8	c1094‐102	c1094‐102	NOUN
bam-4840	135	9	.	.	PROPN
bam-4840	136	1	6	6	NUM
bam-4840	136	2	.	.	NUM
bam-4840	136	3	eltit	eltit	PROPN
bam-4840	136	4	jm	jm	PROPN
bam-4840	136	5	,	,	PUNCT
bam-4840	136	6	bannister	bannister	PROPN
bam-4840	136	7	ra	ra	PROPN
bam-4840	136	8	,	,	PUNCT
bam-4840	136	9	moua	moua	PROPN
bam-4840	136	10	o	o	PROPN
bam-4840	136	11	,	,	PUNCT
bam-4840	136	12	et	et	PROPN
bam-4840	136	13	al	al	PROPN
bam-4840	136	14	.	.	PROPN
bam-4840	136	15	malignant	malignant	ADJ
bam-4840	136	16	hyperthermia	hyperthermia	NOUN
bam-4840	136	17	susceptibility	susceptibility	NOUN
bam-4840	136	18	arising	arise	VERB
bam-4840	136	19	from	from	ADP
bam-4840	136	20	altered	altered	ADJ
bam-4840	136	21	resting	resting	NOUN
bam-4840	136	22	coupling	coupling	NOUN
bam-4840	136	23	between	between	ADP
bam-4840	136	24	the	the	DET
bam-4840	136	25	skeletal	skeletal	ADJ
bam-4840	136	26	muscle	muscle	NOUN
bam-4840	136	27	l‐type	l‐type	PUNCT
bam-4840	136	28	ca	ca	NOUN
bam-4840	136	29	2	2	NUM
bam-4840	136	30	+	+	NOUN
bam-4840	136	31	channel	channel	NOUN
bam-4840	136	32	and	and	CCONJ
bam-4840	136	33	the	the	DET
bam-4840	136	34	type	type	NOUN
bam-4840	136	35	1	1	NUM
bam-4840	136	36	ryanodine	ryanodine	NOUN
bam-4840	136	37	receptor	receptor	NOUN
bam-4840	136	38	.	.	PUNCT
bam-4840	137	1	proc	proc	PROPN
bam-4840	137	2	natl	natl	PROPN
bam-4840	137	3	acad	acad	PROPN
bam-4840	137	4	sci	sci	PROPN
bam-4840	137	5	u	u	PROPN
bam-4840	137	6	s	s	PROPN
bam-4840	137	7	a	a	DET
bam-4840	137	8	2012;109:7923‐8	2012;109:7923‐8	NUM
bam-4840	137	9	.	.	PROPN
bam-4840	138	1	7	7	NUM
bam-4840	138	2	.	.	X
bam-4840	138	3	tong	tong	PROPN
bam-4840	138	4	j	j	PROPN
bam-4840	138	5	,	,	PUNCT
bam-4840	138	6	mccarthy	mccarthy	PROPN
bam-4840	138	7	tv	tv	PROPN
bam-4840	138	8	,	,	PUNCT
bam-4840	138	9	maclennan	maclennan	NOUN
bam-4840	138	10	dh	dh	PROPN
bam-4840	138	11	.	.	PUNCT
bam-4840	138	12	measurement	measurement	NOUN
bam-4840	138	13	of	of	ADP
bam-4840	138	14	resting	rest	VERB
bam-4840	138	15	cytosolic	cytosolic	NOUN
bam-4840	138	16	ca	ca	NOUN
bam-4840	138	17	2	2	NUM
bam-4840	138	18	+	+	NUM
bam-4840	138	19	concentrations	concentration	NOUN
bam-4840	138	20	and	and	CCONJ
bam-4840	138	21	ca	ca	NOUN
bam-4840	138	22	2	2	NUM
bam-4840	138	23	+	+	NUM
bam-4840	138	24	store	store	NOUN
bam-4840	138	25	size	size	NOUN
bam-4840	138	26	in	in	ADP
bam-4840	138	27	hek‐293	hek‐293	NOUN
bam-4840	138	28	cells	cell	NOUN
bam-4840	138	29	transfected	transfecte	VERB
bam-4840	138	30	with	with	ADP
bam-4840	138	31	malignant	malignant	ADJ
bam-4840	138	32	hyperthermia	hyperthermia	NOUN
bam-4840	138	33	or	or	CCONJ
bam-4840	138	34	central	central	ADJ
bam-4840	138	35	core	core	NOUN
bam-4840	138	36	disease	disease	NOUN
bam-4840	138	37	mutant	mutant	NOUN
bam-4840	138	38	ca	ca	NOUN
bam-4840	138	39	2	2	NUM
bam-4840	138	40	+	+	NOUN
bam-4840	138	41	release	release	NOUN
bam-4840	138	42	channels	channel	NOUN
bam-4840	138	43	.	.	PUNCT
bam-4840	139	1	j	j	PROPN
bam-4840	139	2	biol	biol	PROPN
bam-4840	139	3	chem	chem	PROPN
bam-4840	139	4	1999;274	1999;274	NOUN
bam-4840	139	5	:	:	PUNCT
bam-4840	139	6	693‐702	693‐702	NUM
bam-4840	139	7	.	.	PUNCT
bam-4840	140	1	8	8	NUM
bam-4840	140	2	.	.	X
bam-4840	140	3	yang	yang	PROPN
bam-4840	140	4	t	t	PROPN
bam-4840	140	5	,	,	PUNCT
bam-4840	140	6	esteve	esteve	PROPN
bam-4840	140	7	e	e	PROPN
bam-4840	140	8	,	,	PUNCT
bam-4840	140	9	pessah	pessah	VERB
bam-4840	140	10	in	in	ADP
bam-4840	140	11	,	,	PUNCT
bam-4840	140	12	et	et	PROPN
bam-4840	140	13	al	al	PROPN
bam-4840	140	14	.	.	PROPN
bam-4840	140	15	elevated	elevated	PROPN
bam-4840	140	16	resting	rest	VERB
bam-4840	140	17	[	[	X
bam-4840	140	18	ca(2+)](i	ca(2+)](i	NOUN
bam-4840	140	19	)	)	PUNCT
bam-4840	140	20	in	in	ADP
bam-4840	140	21	myotubes	myotube	NOUN
bam-4840	140	22	expressing	express	VERB
bam-4840	140	23	malignant	malignant	ADJ
bam-4840	140	24	hyperthermia	hyperthermia	NOUN
bam-4840	140	25	ryr1	ryr1	NOUN
bam-4840	140	26	cdnas	cdna	NOUN
bam-4840	140	27	is	be	AUX
bam-4840	140	28	partially	partially	ADV
bam-4840	140	29	restored	restore	VERB
bam-4840	140	30	by	by	ADP
bam-4840	140	31	modulation	modulation	NOUN
bam-4840	140	32	of	of	ADP
bam-4840	140	33	passive	passive	ADJ
bam-4840	140	34	calcium	calcium	NOUN
bam-4840	140	35	leak	leak	NOUN
bam-4840	140	36	from	from	ADP
bam-4840	140	37	the	the	DET
bam-4840	140	38	sr	sr	PROPN
bam-4840	140	39	.	.	PUNCT
bam-4840	141	1	am	be	AUX
bam-4840	141	2	j	j	PROPN
bam-4840	141	3	physiol	physiol	PROPN
bam-4840	141	4	cell	cell	PROPN
bam-4840	141	5	physiol	physiol	PROPN
bam-4840	141	6	2007;292	2007;292	NUM
bam-4840	141	7	:	:	PUNCT
bam-4840	141	8	c1591‐8	c1591‐8	ADJ
bam-4840	141	9	.	.	PUNCT
bam-4840	142	1	9	9	X
bam-4840	142	2	.	.	X
bam-4840	142	3	block	block	PROPN
bam-4840	142	4	ba	ba	PROPN
bam-4840	142	5	,	,	PUNCT
bam-4840	142	6	imagawa	imagawa	PROPN
bam-4840	142	7	t	t	PROPN
bam-4840	142	8	,	,	PUNCT
bam-4840	142	9	campbell	campbell	PROPN
bam-4840	142	10	kp	kp	PROPN
bam-4840	142	11	,	,	PUNCT
bam-4840	142	12	franzini‐armstrong	franzini‐armstrong	PROPN
bam-4840	142	13	c.	c.	PROPN
bam-4840	142	14	structural	structural	ADJ
bam-4840	142	15	evidence	evidence	NOUN
bam-4840	142	16	for	for	ADP
bam-4840	142	17	direct	direct	ADJ
bam-4840	142	18	interaction	interaction	NOUN
bam-4840	142	19	between	between	ADP
bam-4840	142	20	the	the	DET
bam-4840	142	21	molecular	molecular	ADJ
bam-4840	142	22	components	component	NOUN
bam-4840	142	23	of	of	ADP
bam-4840	142	24	the	the	DET
bam-4840	142	25	transverse	transverse	NOUN
bam-4840	142	26	tubule	tubule	NOUN
bam-4840	142	27	/	/	SYM
bam-4840	142	28	sarcoplasmic	sarcoplasmic	NOUN
bam-4840	142	29	reticulum	reticulum	NOUN
bam-4840	142	30	junction	junction	NOUN
bam-4840	142	31	in	in	ADP
bam-4840	142	32	skeletal	skeletal	ADJ
bam-4840	142	33	muscle	muscle	NOUN
bam-4840	142	34	.	.	PUNCT
bam-4840	143	1	j	j	PROPN
bam-4840	143	2	cell	cell	NOUN
bam-4840	143	3	biol	biol	PROPN
bam-4840	143	4	1988;107:2587‐600	1988;107:2587‐600	NUM
bam-4840	143	5	.	.	PROPN
bam-4840	143	6	10	10	NUM
bam-4840	143	7	.	.	PUNCT
bam-4840	144	1	protasi	protasi	PROPN
bam-4840	144	2	f	f	PROPN
bam-4840	144	3	,	,	PUNCT
bam-4840	144	4	franzini‐armstrong	franzini‐armstrong	ADJ
bam-4840	144	5	c	c	X
bam-4840	144	6	,	,	PUNCT
bam-4840	144	7	allen	allen	PROPN
bam-4840	144	8	pd	pd	PROPN
bam-4840	144	9	.	.	PROPN
bam-4840	144	10	role	role	NOUN
bam-4840	144	11	of	of	ADP
bam-4840	144	12	ryanodine	ryanodine	NOUN
bam-4840	144	13	receptors	receptor	NOUN
bam-4840	144	14	in	in	ADP
bam-4840	144	15	the	the	DET
bam-4840	144	16	assembly	assembly	NOUN
bam-4840	144	17	of	of	ADP
bam-4840	144	18	calcium	calcium	NOUN
bam-4840	144	19	release	release	NOUN
bam-4840	144	20	units	unit	NOUN
bam-4840	144	21	in	in	ADP
bam-4840	144	22	skeletal	skeletal	ADJ
bam-4840	144	23	muscle	muscle	NOUN
bam-4840	144	24	.	.	PUNCT
bam-4840	145	1	j	j	PROPN
bam-4840	145	2	cell	cell	NOUN
bam-4840	145	3	biol	biol	PROPN
bam-4840	145	4	1998;140:831‐42	1998;140:831‐42	NUM
bam-4840	145	5	.	.	PUNCT
bam-4840	146	1	11	11	NUM
bam-4840	146	2	.	.	PUNCT
bam-4840	147	1	paolini	paolini	PROPN
bam-4840	147	2	c	c	PROPN
bam-4840	147	3	,	,	PUNCT
bam-4840	147	4	fessenden	fessenden	PROPN
bam-4840	147	5	jd	jd	PROPN
bam-4840	147	6	,	,	PUNCT
bam-4840	147	7	pessah	pessah	VERB
bam-4840	147	8	in	in	ADP
bam-4840	147	9	,	,	PUNCT
bam-4840	147	10	et	et	PROPN
bam-4840	147	11	al	al	PROPN
bam-4840	147	12	.	.	PROPN
bam-4840	148	1	evidence	evidence	NOUN
bam-4840	148	2	for	for	ADP
bam-4840	148	3	conformational	conformational	ADJ
bam-4840	148	4	coupling	coupling	NOUN
bam-4840	148	5	between	between	ADP
bam-4840	148	6	two	two	NUM
bam-4840	148	7	calcium	calcium	NOUN
bam-4840	148	8	channels	channel	NOUN
bam-4840	148	9	.	.	PUNCT
bam-4840	149	1	proc	proc	PROPN
bam-4840	149	2	natl	natl	PROPN
bam-4840	149	3	acad	acad	PROPN
bam-4840	149	4	sci	sci	PROPN
bam-4840	149	5	u	u	PROPN
bam-4840	149	6	s	s	PROPN
bam-4840	149	7	a	a	DET
bam-4840	149	8	2004;101:12748‐52	2004;101:12748‐52	PROPN
bam-4840	149	9	.	.	PROPN
bam-4840	149	10	12	12	NUM
bam-4840	149	11	.	.	PUNCT
bam-4840	150	1	leung	leung	PROPN
bam-4840	150	2	at	at	ADP
bam-4840	150	3	,	,	PUNCT
bam-4840	150	4	imagawa	imagawa	PROPN
bam-4840	150	5	t	t	PROPN
bam-4840	150	6	,	,	PUNCT
bam-4840	150	7	block	block	NOUN
bam-4840	150	8	b	b	NOUN
bam-4840	150	9	,	,	PUNCT
bam-4840	150	10	et	et	PROPN
bam-4840	150	11	al	al	PROPN
bam-4840	150	12	.	.	PROPN
bam-4840	151	1	biochemical	biochemical	ADJ
bam-4840	151	2	and	and	CCONJ
bam-4840	151	3	ultrastructural	ultrastructural	ADJ
bam-4840	151	4	characterization	characterization	NOUN
bam-4840	151	5	of	of	ADP
bam-4840	151	6	the	the	DET
bam-4840	151	7	1,4‐dihydropyridine	1,4‐dihydropyridine	PROPN
bam-4840	151	8	receptor	receptor	NOUN
bam-4840	151	9	from	from	ADP
bam-4840	151	10	rabbit	rabbit	NOUN
bam-4840	151	11	skeletal	skeletal	ADJ
bam-4840	151	12	muscle	muscle	NOUN
bam-4840	151	13	.	.	PUNCT
bam-4840	152	1	evidence	evidence	NOUN
bam-4840	152	2	for	for	ADP
bam-4840	152	3	a	a	DET
bam-4840	152	4	52,000	52,000	NUM
bam-4840	152	5	da	da	NOUN
bam-4840	152	6	subunit	subunit	NOUN
bam-4840	152	7	.	.	PUNCT
bam-4840	153	1	j	j	PROPN
bam-4840	153	2	biol	biol	PROPN
bam-4840	153	3	chem	chem	PROPN
bam-4840	153	4	1988;263:994‐1001	1988;263:994‐1001	NUM
bam-4840	153	5	.	.	PROPN
bam-4840	153	6	13	13	NUM
bam-4840	153	7	.	.	PUNCT
bam-4840	154	1	rios	rios	PROPN
bam-4840	154	2	e	e	PROPN
bam-4840	154	3	,	,	PUNCT
bam-4840	154	4	brum	brum	PROPN
bam-4840	154	5	g.	g.	PROPN
bam-4840	154	6	involvement	involvement	NOUN
bam-4840	154	7	of	of	ADP
bam-4840	154	8	dihydropyridine	dihydropyridine	NOUN
bam-4840	154	9	receptors	receptor	NOUN
bam-4840	154	10	in	in	ADP
bam-4840	154	11	excitation‐contraction	excitation‐contraction	NOUN
bam-4840	154	12	coupling	coupling	NOUN
bam-4840	154	13	in	in	ADP
bam-4840	154	14	skeletal	skeletal	ADJ
bam-4840	154	15	muscle	muscle	NOUN
bam-4840	154	16	.	.	PUNCT
bam-4840	155	1	nature	nature	NOUN
bam-4840	155	2	1987;325:717‐20	1987;325:717‐20	NUM
bam-4840	155	3	.	.	PUNCT
bam-4840	156	1	14	14	NUM
bam-4840	156	2	.	.	PUNCT
bam-4840	157	1	tanabe	tanabe	PROPN
bam-4840	157	2	t	t	PROPN
bam-4840	157	3	,	,	PUNCT
bam-4840	157	4	beam	beam	NOUN
bam-4840	157	5	kg	kg	PROPN
bam-4840	157	6	powell	powell	PROPN
bam-4840	157	7	ja	ja	PROPN
bam-4840	157	8	,	,	PUNCT
bam-4840	157	9	numa	numa	PROPN
bam-4840	157	10	s.	s.	PROPN
bam-4840	157	11	restoration	restoration	NOUN
bam-4840	157	12	of	of	ADP
bam-4840	157	13	excitation‐contraction	excitation‐contraction	NOUN
bam-4840	157	14	coupling	couple	VERB
bam-4840	157	15	mailto:msamso@vcu.edu	mailto:msamso@vcu.edu	PROPN
bam-4840	157	16	3d	3d	NUM
bam-4840	157	17	structure	structure	NOUN
bam-4840	157	18	of	of	ADP
bam-4840	157	19	muscle	muscle	NOUN
bam-4840	157	20	dihydropyridine	dihydropyridine	NOUN
bam-4840	157	21	receptor	receptor	PROPN
bam-4840	157	22	eur	eur	PROPN
bam-4840	157	23	j	j	PROPN
bam-4840	157	24	transl	transl	PROPN
bam-4840	157	25	myol	myol	PROPN
bam-4840	157	26	basic	basic	ADJ
bam-4840	157	27	appl	appl	NOUN
bam-4840	157	28	myol	myol	NOUN
bam-4840	157	29	2015	2015	NUM
bam-4840	157	30	;	;	PUNCT
bam-4840	157	31	25	25	NUM
bam-4840	157	32	(	(	PUNCT
bam-4840	157	33	1	1	NUM
bam-4840	157	34	):	):	PUNCT
bam-4840	157	35	27	27	NUM
bam-4840	157	36	-	-	SYM
bam-4840	157	37	33	33	NUM
bam-4840	157	38	32	32	NUM
bam-4840	157	39	and	and	CCONJ
bam-4840	157	40	slow	slow	ADJ
bam-4840	157	41	calcium	calcium	NOUN
bam-4840	157	42	current	current	NOUN
bam-4840	157	43	in	in	ADP
bam-4840	157	44	dysgenic	dysgenic	ADJ
bam-4840	157	45	muscle	muscle	NOUN
bam-4840	157	46	by	by	ADP
bam-4840	157	47	dihydropyridine	dihydropyridine	PROPN
bam-4840	157	48	receptor	receptor	PROPN
bam-4840	157	49	complementary	complementary	PROPN
bam-4840	157	50	dna	dna	PROPN
bam-4840	157	51	.	.	PUNCT
bam-4840	158	1	nature	nature	PROPN
bam-4840	158	2	1988;336:134‐9	1988;336:134‐9	PROPN
bam-4840	158	3	.	.	PROPN
bam-4840	158	4	15	15	NUM
bam-4840	158	5	.	.	PUNCT
bam-4840	159	1	garcia	garcia	PROPN
bam-4840	159	2	j	j	PROPN
bam-4840	159	3	,	,	PUNCT
bam-4840	159	4	tanabe	tanabe	PROPN
bam-4840	159	5	t	t	PROPN
bam-4840	159	6	,	,	PUNCT
bam-4840	159	7	beam	beam	PROPN
bam-4840	159	8	kg	kg	PROPN
bam-4840	159	9	.	.	PUNCT
bam-4840	159	10	relationship	relationship	NOUN
bam-4840	159	11	of	of	ADP
bam-4840	159	12	calcium	calcium	NOUN
bam-4840	159	13	transients	transient	NOUN
bam-4840	159	14	to	to	ADP
bam-4840	159	15	calcium	calcium	NOUN
bam-4840	159	16	currents	current	NOUN
bam-4840	159	17	and	and	CCONJ
bam-4840	159	18	charge	charge	NOUN
bam-4840	159	19	movements	movement	NOUN
bam-4840	159	20	in	in	ADP
bam-4840	159	21	myotubes	myotube	NOUN
bam-4840	159	22	expressing	express	VERB
bam-4840	159	23	skeletal	skeletal	ADJ
bam-4840	159	24	and	and	CCONJ
bam-4840	159	25	cardiac	cardiac	ADJ
bam-4840	159	26	dihydropyridine	dihydropyridine	NOUN
bam-4840	159	27	receptors	receptor	NOUN
bam-4840	159	28	.	.	PUNCT
bam-4840	160	1	j	j	PROPN
bam-4840	160	2	gen	gen	PROPN
bam-4840	160	3	physiol	physiol	PROPN
bam-4840	160	4	1994;103:125‐47	1994;103:125‐47	NUM
bam-4840	160	5	.	.	PUNCT
bam-4840	161	1	16	16	NUM
bam-4840	161	2	.	.	PUNCT
bam-4840	162	1	armstrong	armstrong	PROPN
bam-4840	162	2	cm	cm	PROPN
bam-4840	162	3	,	,	PUNCT
bam-4840	162	4	bezanilla	bezanilla	NOUN
bam-4840	162	5	fm	fm	PROPN
bam-4840	162	6	,	,	PUNCT
bam-4840	162	7	horowicz	horowicz	VERB
bam-4840	162	8	p.twitches	p.twitche	NOUN
bam-4840	162	9	in	in	ADP
bam-4840	162	10	the	the	DET
bam-4840	162	11	presence	presence	NOUN
bam-4840	162	12	of	of	ADP
bam-4840	162	13	ethylene	ethylene	NOUN
bam-4840	162	14	glycol	glycol	NOUN
bam-4840	162	15	bis	bis	PROPN
bam-4840	162	16	(	(	PUNCT
bam-4840	162	17	‐aminoethyl	‐aminoethyl	PROPN
bam-4840	162	18	ether)‐n	ether)‐n	X
bam-4840	162	19	,	,	PUNCT
bam-4840	162	20	n'‐tetracetic	n'‐tetracetic	ADJ
bam-4840	162	21	acid	acid	NOUN
bam-4840	162	22	.	.	PUNCT
bam-4840	163	1	biochim	biochim	PROPN
bam-4840	163	2	biophys	biophy	NOUN
bam-4840	163	3	acta	acta	PROPN
bam-4840	163	4	1972;267:605‐8	1972;267:605‐8	PROPN
bam-4840	163	5	.	.	PROPN
bam-4840	163	6	17	17	NUM
bam-4840	163	7	.	.	PUNCT
bam-4840	164	1	tanabe	tanabe	PROPN
bam-4840	164	2	t	t	PROPN
bam-4840	164	3	,	,	PUNCT
bam-4840	164	4	beam	beam	NOUN
bam-4840	164	5	kg	kg	PROPN
bam-4840	164	6	,	,	PUNCT
bam-4840	164	7	adams	adams	PROPN
bam-4840	164	8	ba	ba	PROPN
bam-4840	164	9	,	,	PUNCT
bam-4840	164	10	et	et	PROPN
bam-4840	164	11	al	al	PROPN
bam-4840	164	12	.	.	PROPN
bam-4840	164	13	regions	region	NOUN
bam-4840	164	14	of	of	ADP
bam-4840	164	15	the	the	DET
bam-4840	164	16	skeletal	skeletal	ADJ
bam-4840	164	17	muscle	muscle	NOUN
bam-4840	164	18	dihydropyridine	dihydropyridine	NOUN
bam-4840	164	19	receptor	receptor	NOUN
bam-4840	164	20	critical	critical	ADJ
bam-4840	164	21	for	for	ADP
bam-4840	164	22	excitation‐contraction	excitation‐contraction	NOUN
bam-4840	164	23	coupling	coupling	NOUN
bam-4840	164	24	.	.	PUNCT
bam-4840	165	1	nature	nature	NOUN
bam-4840	165	2	1990;346:567‐9	1990;346:567‐9	PROPN
bam-4840	165	3	.	.	PUNCT
bam-4840	166	1	18	18	NUM
bam-4840	166	2	.	.	PUNCT
bam-4840	167	1	kugler	kugler	PROPN
bam-4840	167	2	g	g	PROPN
bam-4840	167	3	,	,	PUNCT
bam-4840	167	4	weiss	weiss	PROPN
bam-4840	167	5	rg	rg	PROPN
bam-4840	167	6	,	,	PUNCT
bam-4840	167	7	flucher	flucher	PROPN
bam-4840	167	8	be	be	AUX
bam-4840	167	9	,	,	PUNCT
bam-4840	167	10	grabner	grabner	NOUN
bam-4840	167	11	,	,	PUNCT
bam-4840	167	12	m.	m.	NOUN
bam-4840	167	13	structural	structural	ADJ
bam-4840	167	14	requirements	requirement	NOUN
bam-4840	167	15	of	of	ADP
bam-4840	167	16	the	the	DET
bam-4840	167	17	dihydropyridine	dihydropyridine	NOUN
bam-4840	167	18	receptor	receptor	NOUN
bam-4840	167	19	alpha1s	alpha1s	PROPN
bam-4840	167	20	ii‐iii	ii‐iii	PROPN
bam-4840	167	21	loop	loop	NOUN
bam-4840	167	22	for	for	ADP
bam-4840	167	23	skeletal‐type	skeletal‐type	NOUN
bam-4840	167	24	excitation‐contraction	excitation‐contraction	NOUN
bam-4840	167	25	coupling	coupling	NOUN
bam-4840	167	26	.	.	PUNCT
bam-4840	168	1	j	j	PROPN
bam-4840	168	2	biol	biol	PROPN
bam-4840	168	3	chem	chem	NOUN
bam-4840	168	4	2004;279:4721‐8	2004;279:4721‐8	NOUN
bam-4840	168	5	.	.	PUNCT
bam-4840	169	1	19	19	NUM
bam-4840	169	2	.	.	PUNCT
bam-4840	170	1	coronado	coronado	PROPN
bam-4840	170	2	r	r	PROPN
bam-4840	170	3	,	,	PUNCT
bam-4840	170	4	ahern	ahern	PROPN
bam-4840	170	5	ca	ca	PROPN
bam-4840	170	6	,	,	PUNCT
bam-4840	170	7	sheridan	sheridan	PROPN
bam-4840	170	8	dc	dc	PROPN
bam-4840	170	9	,	,	PUNCT
bam-4840	170	10	et	et	PROPN
bam-4840	170	11	al	al	PROPN
bam-4840	170	12	.	.	PROPN
bam-4840	170	13	functional	functional	ADJ
bam-4840	170	14	equivalence	equivalence	NOUN
bam-4840	170	15	of	of	ADP
bam-4840	170	16	dihydropyridine	dihydropyridine	NOUN
bam-4840	170	17	receptor	receptor	NOUN
bam-4840	170	18	alpha1s	alpha1s	PROPN
bam-4840	170	19	and	and	CCONJ
bam-4840	170	20	beta1a	beta1a	PROPN
bam-4840	170	21	subunits	subunit	NOUN
bam-4840	170	22	in	in	ADP
bam-4840	170	23	triggering	trigger	VERB
bam-4840	170	24	excitation‐contraction	excitation‐contraction	NOUN
bam-4840	170	25	coupling	coupling	NOUN
bam-4840	170	26	in	in	ADP
bam-4840	170	27	skeletal	skeletal	ADJ
bam-4840	170	28	muscle	muscle	NOUN
bam-4840	170	29	.	.	PUNCT
bam-4840	171	1	biol	biol	PROPN
bam-4840	171	2	res	re	NOUN
bam-4840	171	3	2004;37:565‐75	2004;37:565‐75	PROPN
bam-4840	171	4	.	.	PROPN
bam-4840	171	5	20	20	NUM
bam-4840	171	6	.	.	PUNCT
bam-4840	172	1	takekura	takekura	ADJ
bam-4840	172	2	h	h	PROPN
bam-4840	172	3	,	,	PUNCT
bam-4840	172	4	paolini	paolini	PROPN
bam-4840	172	5	c	c	PROPN
bam-4840	172	6	,	,	PUNCT
bam-4840	172	7	franzini‐armstrong	franzini‐armstrong	ADJ
bam-4840	172	8	c	c	X
bam-4840	172	9	,	,	PUNCT
bam-4840	172	10	et	et	PROPN
bam-4840	172	11	al	al	PROPN
bam-4840	172	12	.	.	PROPN
bam-4840	172	13	differential	differential	PROPN
bam-4840	172	14	contribution	contribution	NOUN
bam-4840	172	15	of	of	ADP
bam-4840	172	16	skeletal	skeletal	ADJ
bam-4840	172	17	and	and	CCONJ
bam-4840	172	18	cardiac	cardiac	ADJ
bam-4840	172	19	ii‐iii	ii‐iii	PROPN
bam-4840	172	20	loop	loop	NOUN
bam-4840	172	21	sequences	sequence	NOUN
bam-4840	172	22	to	to	ADP
bam-4840	172	23	the	the	DET
bam-4840	172	24	assembly	assembly	NOUN
bam-4840	172	25	of	of	ADP
bam-4840	172	26	dihydropyridine‐receptor	dihydropyridine‐receptor	NOUN
bam-4840	172	27	arrays	array	VERB
bam-4840	172	28	in	in	ADP
bam-4840	172	29	skeletal	skeletal	ADJ
bam-4840	172	30	muscle	muscle	NOUN
bam-4840	172	31	.	.	PUNCT
bam-4840	173	1	mol	mol	ADP
bam-4840	173	2	biol	biol	PROPN
bam-4840	173	3	cell	cell	NOUN
bam-4840	173	4	2004;15:5408	2004;15:5408	NUM
bam-4840	173	5	-	-	SYM
bam-4840	173	6	19	19	NUM
bam-4840	173	7	.	.	NOUN
bam-4840	173	8	21	21	NUM
bam-4840	173	9	.	.	PUNCT
bam-4840	173	10	schredelseker	schredelseker	PROPN
bam-4840	173	11	j	j	PROPN
bam-4840	173	12	,	,	PUNCT
bam-4840	173	13	di	di	X
bam-4840	173	14	biase	biase	PROPN
bam-4840	173	15	v	v	PROPN
bam-4840	173	16	,	,	PUNCT
bam-4840	173	17	obermair	obermair	NOUN
bam-4840	173	18	gj	gj	PROPN
bam-4840	173	19	,	,	PUNCT
bam-4840	173	20	et	et	PROPN
bam-4840	173	21	al	al	PROPN
bam-4840	173	22	.	.	PUNCT
bam-4840	174	1	the	the	DET
bam-4840	174	2	beta	beta	PROPN
bam-4840	174	3	1a	1a	X
bam-4840	174	4	subunit	subunit	NOUN
bam-4840	174	5	is	be	AUX
bam-4840	174	6	essential	essential	ADJ
bam-4840	174	7	for	for	SCONJ
bam-4840	174	8	the	the	DET
bam-4840	174	9	assembly	assembly	NOUN
bam-4840	174	10	of	of	ADP
bam-4840	174	11	dihydropyridine‐receptor	dihydropyridine‐receptor	NOUN
bam-4840	174	12	arrays	array	VERB
bam-4840	174	13	in	in	ADP
bam-4840	174	14	skeletal	skeletal	ADJ
bam-4840	174	15	muscle	muscle	NOUN
bam-4840	174	16	.	.	PUNCT
bam-4840	175	1	proc	proc	PROPN
bam-4840	175	2	natl	natl	PROPN
bam-4840	175	3	acad	acad	PROPN
bam-4840	175	4	sci	sci	PROPN
bam-4840	175	5	u	u	PROPN
bam-4840	175	6	s	s	PROPN
bam-4840	175	7	a	a	DET
bam-4840	175	8	2005;102:17219‐24	2005;102:17219‐24	PROPN
bam-4840	175	9	.	.	PROPN
bam-4840	175	10	22	22	NUM
bam-4840	175	11	.	.	PUNCT
bam-4840	176	1	gach	gach	PROPN
bam-4840	176	2	mp	mp	PROPN
bam-4840	176	3	,	,	PUNCT
bam-4840	176	4	cherednichenko	cherednichenko	VERB
bam-4840	176	5	g	g	PROPN
bam-4840	176	6	,	,	PUNCT
bam-4840	176	7	haarmann	haarmann	PROPN
bam-4840	176	8	c	c	AUX
bam-4840	176	9	,	,	PUNCT
bam-4840	176	10	et	et	PROPN
bam-4840	176	11	al	al	PROPN
bam-4840	176	12	.	.	PUNCT
bam-4840	177	1	alpha2	alpha2	NOUN
bam-4840	177	2	delta1	delta1	NOUN
bam-4840	177	3	dihydropyridine	dihydropyridine	NOUN
bam-4840	177	4	receptor	receptor	NOUN
bam-4840	177	5	subunit	subunit	NOUN
bam-4840	177	6	is	be	AUX
bam-4840	177	7	a	a	DET
bam-4840	177	8	critical	critical	ADJ
bam-4840	177	9	element	element	NOUN
bam-4840	177	10	for	for	ADP
bam-4840	177	11	excitation‐coupled	excitation‐couple	VERB
bam-4840	177	12	calcium	calcium	NOUN
bam-4840	177	13	entry	entry	NOUN
bam-4840	177	14	but	but	CCONJ
bam-4840	177	15	not	not	PART
bam-4840	177	16	for	for	ADP
bam-4840	177	17	formation	formation	NOUN
bam-4840	177	18	of	of	ADP
bam-4840	177	19	tetrads	tetrad	NOUN
bam-4840	177	20	in	in	ADP
bam-4840	177	21	skeletal	skeletal	ADJ
bam-4840	177	22	myotubes	myotube	NOUN
bam-4840	177	23	.	.	PUNCT
bam-4840	178	1	biophys	biophys	PROPN
bam-4840	178	2	j	j	PROPN
bam-4840	178	3	2008;94:3023‐34	2008;94:3023‐34	NUM
bam-4840	178	4	.	.	PUNCT
bam-4840	178	5	23	23	NUM
bam-4840	178	6	.	.	PUNCT
bam-4840	179	1	torres	torre	VERB
bam-4840	179	2	j	j	PROPN
bam-4840	179	3	,	,	PUNCT
bam-4840	179	4	stevens	stevens	PROPN
bam-4840	179	5	tj	tj	PROPN
bam-4840	179	6	,	,	PUNCT
bam-4840	179	7	samso	samso	ADJ
bam-4840	179	8	m.	m.	NOUN
bam-4840	179	9	membrane	membrane	NOUN
bam-4840	179	10	proteins	protein	NOUN
bam-4840	179	11	:	:	PUNCT
bam-4840	179	12	the	the	DET
bam-4840	179	13	'	'	PUNCT
bam-4840	179	14	wild	wild	ADJ
bam-4840	179	15	west	west	NOUN
bam-4840	179	16	'	'	PUNCT
bam-4840	179	17	of	of	ADP
bam-4840	179	18	structural	structural	ADJ
bam-4840	179	19	biology	biology	NOUN
bam-4840	179	20	.	.	PUNCT
bam-4840	180	1	trends	trend	NOUN
bam-4840	180	2	biochem	biochem	PROPN
bam-4840	180	3	sci	sci	PROPN
bam-4840	180	4	2003;28:137‐44	2003;28:137‐44	NUM
bam-4840	180	5	.	.	PROPN
bam-4840	180	6	24	24	NUM
bam-4840	180	7	.	.	PUNCT
bam-4840	180	8	takekura	takekura	ADJ
bam-4840	180	9	h	h	NOUN
bam-4840	180	10	,	,	PUNCT
bam-4840	180	11	takeshima	takeshima	NOUN
bam-4840	180	12	h	h	NOUN
bam-4840	180	13	,	,	PUNCT
bam-4840	180	14	nishimura	nishimura	PROPN
bam-4840	180	15	s	s	PROPN
bam-4840	180	16	,	,	PUNCT
bam-4840	180	17	et	et	PROPN
bam-4840	180	18	al	al	PROPN
bam-4840	180	19	.	.	PROPN
bam-4840	180	20	co‐expression	co‐expression	PROPN
bam-4840	180	21	in	in	ADP
bam-4840	180	22	cho	cho	PROPN
bam-4840	180	23	cells	cell	NOUN
bam-4840	180	24	of	of	ADP
bam-4840	180	25	two	two	NUM
bam-4840	180	26	muscle	muscle	NOUN
bam-4840	180	27	proteins	protein	NOUN
bam-4840	180	28	involved	involve	VERB
bam-4840	180	29	in	in	ADP
bam-4840	180	30	excitation‐contraction	excitation‐contraction	NOUN
bam-4840	180	31	coupling	coupling	NOUN
bam-4840	180	32	.	.	PUNCT
bam-4840	181	1	j	j	PROPN
bam-4840	181	2	muscle	muscle	NOUN
bam-4840	181	3	res	re	NOUN
bam-4840	181	4	cell	cell	NOUN
bam-4840	181	5	motil	motil	NOUN
bam-4840	181	6	1995;16:465‐80	1995;16:465‐80	NUM
bam-4840	181	7	.	.	PROPN
bam-4840	181	8	25	25	NUM
bam-4840	181	9	.	.	PUNCT
bam-4840	182	1	szpyt	szpyt	PROPN
bam-4840	182	2	j	j	PROPN
bam-4840	182	3	,	,	PUNCT
bam-4840	182	4	lorenzon	lorenzon	PROPN
bam-4840	182	5	n	n	PROPN
bam-4840	182	6	,	,	PUNCT
bam-4840	182	7	perez	perez	PROPN
bam-4840	182	8	cf	cf	PROPN
bam-4840	182	9	,	,	PUNCT
bam-4840	182	10	et	et	PROPN
bam-4840	182	11	al	al	PROPN
bam-4840	182	12	.	.	PUNCT
bam-4840	183	1	three‐dimensional	three‐dimensional	ADJ
bam-4840	183	2	localization	localization	NOUN
bam-4840	183	3	of	of	ADP
bam-4840	183	4	the	the	DET
bam-4840	183	5	alpha	alpha	NOUN
bam-4840	183	6	and	and	CCONJ
bam-4840	183	7	beta	beta	NOUN
bam-4840	183	8	subunits	subunit	NOUN
bam-4840	183	9	and	and	CCONJ
bam-4840	183	10	of	of	ADP
bam-4840	183	11	the	the	DET
bam-4840	183	12	ii‐iii	ii‐iii	PROPN
bam-4840	183	13	loop	loop	NOUN
bam-4840	183	14	in	in	ADP
bam-4840	183	15	the	the	DET
bam-4840	183	16	skeletal	skeletal	ADJ
bam-4840	183	17	muscle	muscle	NOUN
bam-4840	183	18	l‐type	l‐type	PUNCT
bam-4840	183	19	ca	ca	NOUN
bam-4840	183	20	2	2	NUM
bam-4840	183	21	+	+	NUM
bam-4840	183	22	channel	channel	NOUN
bam-4840	183	23	.	.	PUNCT
bam-4840	184	1	j	j	PROPN
bam-4840	184	2	biol	biol	PROPN
bam-4840	184	3	chem	chem	PROPN
bam-4840	184	4	2012;287:43853‐61	2012;287:43853‐61	NUM
bam-4840	184	5	.	.	PROPN
bam-4840	184	6	26	26	NUM
bam-4840	184	7	.	.	PUNCT
bam-4840	185	1	shaikh	shaikh	PROPN
bam-4840	185	2	tr	tr	VERB
bam-4840	185	3	,	,	PUNCT
bam-4840	185	4	gao	gao	PROPN
bam-4840	185	5	h	h	PROPN
bam-4840	185	6	,	,	PUNCT
bam-4840	185	7	baxter	baxter	PROPN
bam-4840	185	8	wt	wt	PROPN
bam-4840	185	9	,	,	PUNCT
bam-4840	185	10	et	et	PROPN
bam-4840	185	11	al	al	PROPN
bam-4840	185	12	.	.	PROPN
bam-4840	186	1	spider	spider	NOUN
bam-4840	186	2	image	image	NOUN
bam-4840	186	3	processing	processing	NOUN
bam-4840	186	4	for	for	ADP
bam-4840	186	5	single‐particle	single‐particle	NOUN
bam-4840	186	6	reconstruction	reconstruction	NOUN
bam-4840	186	7	of	of	ADP
bam-4840	186	8	biological	biological	ADJ
bam-4840	186	9	macromolecules	macromolecule	NOUN
bam-4840	186	10	from	from	ADP
bam-4840	186	11	electron	electron	NOUN
bam-4840	186	12	micrographs	micrograph	NOUN
bam-4840	186	13	.	.	PUNCT
bam-4840	187	1	nat	nat	PROPN
bam-4840	187	2	protoc	protoc	VERB
bam-4840	187	3	2008;3:1941‐74	2008;3:1941‐74	NOUN
bam-4840	187	4	.	.	PROPN
bam-4840	187	5	27	27	NUM
bam-4840	187	6	.	.	PUNCT
bam-4840	188	1	ludtke	ludtke	PROPN
bam-4840	188	2	sj	sj	PROPN
bam-4840	188	3	,	,	PUNCT
bam-4840	188	4	baldwin	baldwin	PROPN
bam-4840	188	5	pr	pr	PROPN
bam-4840	188	6	,	,	PUNCT
bam-4840	188	7	chiu	chiu	PROPN
bam-4840	188	8	w.	w.	PROPN
bam-4840	188	9	eman	eman	PROPN
bam-4840	188	10	:	:	PUNCT
bam-4840	188	11	semiautomated	semiautomate	VERB
bam-4840	188	12	software	software	NOUN
bam-4840	188	13	for	for	ADP
bam-4840	188	14	high‐resolution	high‐resolution	NOUN
bam-4840	188	15	single‐particle	single‐particle	NOUN
bam-4840	188	16	reconstructions	reconstruction	NOUN
bam-4840	188	17	.	.	PUNCT
bam-4840	189	1	j	j	PROPN
bam-4840	189	2	struct	struct	VERB
bam-4840	189	3	biol	biol	PROPN
bam-4840	189	4	1999;128:82‐97	1999;128:82‐97	NUM
bam-4840	189	5	.	.	PUNCT
bam-4840	189	6	28	28	NUM
bam-4840	189	7	.	.	PUNCT
bam-4840	190	1	samso	samso	PROPN
bam-4840	190	2	m	m	PROPN
bam-4840	190	3	,	,	PUNCT
bam-4840	190	4	wagenknecht	wagenknecht	PROPN
bam-4840	190	5	t	t	PROPN
bam-4840	190	6	,	,	PUNCT
bam-4840	190	7	allen	allen	PROPN
bam-4840	190	8	pd	pd	PROPN
bam-4840	190	9	.	.	PROPN
bam-4840	190	10	internal	internal	ADJ
bam-4840	190	11	structure	structure	NOUN
bam-4840	190	12	and	and	CCONJ
bam-4840	190	13	visualization	visualization	NOUN
bam-4840	190	14	of	of	ADP
bam-4840	190	15	transmembrane	transmembrane	ADJ
bam-4840	190	16	domains	domain	NOUN
bam-4840	190	17	of	of	ADP
bam-4840	190	18	the	the	DET
bam-4840	190	19	ryr1	ryr1	NOUN
bam-4840	190	20	calcium	calcium	NOUN
bam-4840	190	21	release	release	NOUN
bam-4840	190	22	channel	channel	NOUN
bam-4840	190	23	by	by	ADP
bam-4840	190	24	cryo‐em	cryo‐em	PROPN
bam-4840	190	25	.	.	PUNCT
bam-4840	191	1	nat	nat	PROPN
bam-4840	191	2	struct	struct	NOUN
bam-4840	191	3	mol	mol	ADP
bam-4840	191	4	biol	biol	PROPN
bam-4840	191	5	2005;12:539‐44	2005;12:539‐44	NUM
bam-4840	191	6	.	.	PROPN
bam-4840	191	7	29	29	NUM
bam-4840	191	8	.	.	PUNCT
bam-4840	192	1	murata	murata	PROPN
bam-4840	192	2	k	k	PROPN
bam-4840	192	3	,	,	PUNCT
bam-4840	192	4	nishimura	nishimura	PROPN
bam-4840	192	5	s	s	PROPN
bam-4840	192	6	,	,	PUNCT
bam-4840	192	7	kuniyasu	kuniyasu	VERB
bam-4840	192	8	a	a	PRON
bam-4840	192	9	,	,	PUNCT
bam-4840	192	10	nakayama	nakayama	PROPN
bam-4840	192	11	h.	h.	PROPN
bam-4840	192	12	three‐dimensional	three‐dimensional	ADJ
bam-4840	192	13	structure	structure	NOUN
bam-4840	192	14	of	of	ADP
bam-4840	192	15	the	the	DET
bam-4840	192	16	alpha1‐beta	alpha1‐beta	PROPN
bam-4840	192	17	complex	complex	NOUN
bam-4840	192	18	in	in	ADP
bam-4840	192	19	the	the	DET
bam-4840	192	20	skeletal	skeletal	ADJ
bam-4840	192	21	muscle	muscle	NOUN
bam-4840	192	22	dihydropyridine	dihydropyridine	NOUN
bam-4840	192	23	receptor	receptor	NOUN
bam-4840	192	24	by	by	ADP
bam-4840	192	25	single‐particle	single‐particle	PROPN
bam-4840	192	26	electron	electron	NOUN
bam-4840	192	27	microscopy	microscopy	PROPN
bam-4840	192	28	.	.	PUNCT
bam-4840	193	1	j	j	PROPN
bam-4840	193	2	electron	electron	PROPN
bam-4840	193	3	microsc	microsc	PROPN
bam-4840	193	4	(	(	PUNCT
bam-4840	193	5	tokyo	tokyo	PROPN
bam-4840	193	6	)	)	PUNCT
bam-4840	193	7	2010;59:215‐26	2010;59:215‐26	NUM
bam-4840	193	8	.	.	PUNCT
bam-4840	193	9	30	30	NUM
bam-4840	193	10	.	.	PUNCT
bam-4840	194	1	wolf	wolf	PROPN
bam-4840	194	2	m	m	PROPN
bam-4840	194	3	,	,	PUNCT
bam-4840	194	4	eberhart	eberhart	NOUN
bam-4840	194	5	a	a	X
bam-4840	194	6	,	,	PUNCT
bam-4840	194	7	glossmann	glossmann	ADJ
bam-4840	194	8	h	h	NOUN
bam-4840	194	9	,	,	PUNCT
bam-4840	194	10	et	et	PROPN
bam-4840	194	11	al	al	PROPN
bam-4840	194	12	.	.	PUNCT
bam-4840	194	13	visualization	visualization	NOUN
bam-4840	194	14	of	of	ADP
bam-4840	194	15	the	the	DET
bam-4840	194	16	domain	domain	NOUN
bam-4840	194	17	structure	structure	NOUN
bam-4840	194	18	of	of	ADP
bam-4840	194	19	an	an	DET
bam-4840	194	20	l‐type	l‐type	PUNCT
bam-4840	194	21	ca	ca	NOUN
bam-4840	194	22	2	2	NUM
bam-4840	194	23	+	+	NOUN
bam-4840	194	24	channel	channel	NOUN
bam-4840	194	25	using	use	VERB
bam-4840	194	26	electron	electron	NOUN
bam-4840	194	27	cryo‐microscopy	cryo‐microscopy	NOUN
bam-4840	194	28	.	.	PUNCT
bam-4840	195	1	j	j	PROPN
bam-4840	195	2	mol	mol	ADP
bam-4840	195	3	biol	biol	PROPN
bam-4840	195	4	2003;332:171‐82	2003;332:171‐82	NUM
bam-4840	195	5	.	.	PUNCT
bam-4840	196	1	31	31	NUM
bam-4840	196	2	.	.	PUNCT
bam-4840	196	3	yu	yu	PROPN
bam-4840	196	4	fh	fh	PROPN
bam-4840	196	5	,	,	PUNCT
bam-4840	196	6	yarov‐yarovoy	yarov‐yarovoy	X
bam-4840	196	7	v	v	NOUN
bam-4840	196	8	,	,	PUNCT
bam-4840	196	9	gutman	gutman	PROPN
bam-4840	196	10	ga	ga	PROPN
bam-4840	196	11	,	,	PUNCT
bam-4840	196	12	catterall	catterall	PROPN
bam-4840	196	13	wa	wa	PROPN
bam-4840	196	14	.	.	PROPN
bam-4840	197	1	overview	overview	NOUN
bam-4840	197	2	of	of	ADP
bam-4840	197	3	molecular	molecular	ADJ
bam-4840	197	4	relationships	relationship	NOUN
bam-4840	197	5	in	in	ADP
bam-4840	197	6	the	the	DET
bam-4840	197	7	voltage‐gated	voltage‐gate	VERB
bam-4840	197	8	ion	ion	NOUN
bam-4840	197	9	channel	channel	NOUN
bam-4840	197	10	superfamily	superfamily	NOUN
bam-4840	197	11	.	.	PUNCT
bam-4840	198	1	pharmacol	pharmacol	PROPN
bam-4840	198	2	rev	rev	PROPN
bam-4840	198	3	2005;57:387‐95	2005;57:387‐95	NUM
bam-4840	198	4	.	.	PROPN
bam-4840	198	5	32	32	NUM
bam-4840	198	6	.	.	PUNCT
bam-4840	199	1	payandeh	payandeh	PROPN
bam-4840	199	2	j	j	PROPN
bam-4840	199	3	,	,	PUNCT
bam-4840	199	4	scheuer	scheuer	PROPN
bam-4840	199	5	t	t	PROPN
bam-4840	199	6	,	,	PUNCT
bam-4840	199	7	zheng	zheng	PROPN
bam-4840	199	8	n	n	SYM
bam-4840	199	9	,	,	PUNCT
bam-4840	199	10	catterall	catterall	PROPN
bam-4840	199	11	,	,	PUNCT
bam-4840	199	12	wa	wa	PROPN
bam-4840	199	13	.	.	PUNCT
bam-4840	200	1	the	the	DET
bam-4840	200	2	crystal	crystal	NOUN
bam-4840	200	3	structure	structure	NOUN
bam-4840	200	4	of	of	ADP
bam-4840	200	5	a	a	DET
bam-4840	200	6	voltage‐gated	voltage‐gate	VERB
bam-4840	200	7	sodium	sodium	NOUN
bam-4840	200	8	channel	channel	NOUN
bam-4840	200	9	.	.	PUNCT
bam-4840	201	1	nature	nature	NOUN
bam-4840	201	2	2011;475:353‐8	2011;475:353‐8	PROPN
bam-4840	201	3	.	.	PUNCT
bam-4840	202	1	33	33	NUM
bam-4840	202	2	.	.	PUNCT
bam-4840	203	1	catterall	catterall	PROPN
bam-4840	203	2	wa	wa	PROPN
bam-4840	203	3	,	,	PUNCT
bam-4840	203	4	perez‐reyes	perez‐reye	NOUN
bam-4840	203	5	e	e	NOUN
bam-4840	203	6	,	,	PUNCT
bam-4840	203	7	snutch	snutch	NOUN
bam-4840	203	8	,	,	PUNCT
bam-4840	203	9	tp	tp	ADP
bam-4840	203	10	striessnig	striessnig	NOUN
bam-4840	203	11	.	.	PUNCT
bam-4840	204	1	j	j	PROPN
bam-4840	204	2	international	international	PROPN
bam-4840	204	3	union	union	PROPN
bam-4840	204	4	of	of	ADP
bam-4840	204	5	pharmacology	pharmacology	NOUN
bam-4840	204	6	.	.	PUNCT
bam-4840	205	1	xlviii	xlviii	PROPN
bam-4840	205	2	.	.	PUNCT
bam-4840	206	1	nomenclature	nomenclature	NOUN
bam-4840	206	2	and	and	CCONJ
bam-4840	206	3	structure‐function	structure‐function	NOUN
bam-4840	206	4	relationships	relationship	NOUN
bam-4840	206	5	of	of	ADP
bam-4840	206	6	voltage‐gated	voltage‐gate	VERB
bam-4840	206	7	calcium	calcium	NOUN
bam-4840	206	8	channels	channel	NOUN
bam-4840	206	9	.	.	PUNCT
bam-4840	207	1	pharmacol	pharmacol	PROPN
bam-4840	207	2	rev	rev	PROPN
bam-4840	207	3	2005;57:411‐25	2005;57:411‐25	NUM
bam-4840	207	4	.	.	PROPN
bam-4840	207	5	34	34	NUM
bam-4840	207	6	.	.	PUNCT
bam-4840	207	7	pragnell	pragnell	PROPN
bam-4840	207	8	m	m	PROPN
bam-4840	207	9	,	,	PUNCT
bam-4840	207	10	de	de	X
bam-4840	207	11	waard	waard	PROPN
bam-4840	207	12	m	m	PROPN
bam-4840	207	13	,	,	PUNCT
bam-4840	207	14	mori	mori	PROPN
bam-4840	207	15	y	y	PROPN
bam-4840	207	16	,	,	PUNCT
bam-4840	207	17	et	et	PROPN
bam-4840	207	18	al	al	PROPN
bam-4840	207	19	.	.	PROPN
bam-4840	207	20	calcium	calcium	NOUN
bam-4840	207	21	channel	channel	PROPN
bam-4840	207	22	beta‐subunit	beta‐subunit	NOUN
bam-4840	207	23	binds	bind	VERB
bam-4840	207	24	to	to	ADP
bam-4840	207	25	a	a	DET
bam-4840	207	26	conserved	conserved	ADJ
bam-4840	207	27	motif	motif	NOUN
bam-4840	207	28	in	in	ADP
bam-4840	207	29	the	the	DET
bam-4840	207	30	i‐ii	i‐ii	ADJ
bam-4840	207	31	cytoplasmic	cytoplasmic	ADJ
bam-4840	207	32	linker	linker	NOUN
bam-4840	207	33	of	of	ADP
bam-4840	207	34	the	the	DET
bam-4840	207	35	alpha	alpha	NOUN
bam-4840	207	36	1‐subunit	1‐subunit	NUM
bam-4840	207	37	.	.	PUNCT
bam-4840	208	1	nature	nature	PROPN
bam-4840	208	2	1994;368:67‐70	1994;368:67‐70	PROPN
bam-4840	208	3	.	.	PUNCT
bam-4840	209	1	35	35	NUM
bam-4840	209	2	.	.	PUNCT
bam-4840	210	1	opatowsky	opatowsky	PROPN
bam-4840	210	2	y	y	PROPN
bam-4840	210	3	,	,	PUNCT
bam-4840	210	4	chen	chen	PROPN
bam-4840	210	5	cc	cc	PROPN
bam-4840	210	6	,	,	PUNCT
bam-4840	210	7	campbell	campbell	PROPN
bam-4840	210	8	k	k	PROPN
bam-4840	210	9	,	,	PUNCT
bam-4840	210	10	phirsch	phirsch	PROPN
bam-4840	210	11	,	,	PUNCT
bam-4840	210	12	ja	ja	PROPN
bam-4840	210	13	.	.	PROPN
bam-4840	210	14	structural	structural	ADJ
bam-4840	210	15	analysis	analysis	NOUN
bam-4840	210	16	of	of	ADP
bam-4840	210	17	the	the	DET
bam-4840	210	18	voltage	voltage	NOUN
bam-4840	210	19	-	-	PUNCT
bam-4840	210	20	dependent	dependent	ADJ
bam-4840	210	21	calcium	calcium	NOUN
bam-4840	210	22	channel	channel	NOUN
bam-4840	210	23	beta	beta	ADJ
bam-4840	210	24	subunit	subunit	NOUN
bam-4840	210	25	functional	functional	ADJ
bam-4840	210	26	core	core	NOUN
bam-4840	210	27	and	and	CCONJ
bam-4840	210	28	its	its	PRON
bam-4840	210	29	complex	complex	NOUN
bam-4840	210	30	with	with	ADP
bam-4840	210	31	the	the	DET
bam-4840	210	32	alpha	alpha	ADJ
bam-4840	210	33	1	1	NUM
bam-4840	210	34	interaction	interaction	NOUN
bam-4840	210	35	domain	domain	NOUN
bam-4840	210	36	.	.	PUNCT
bam-4840	211	1	neuron	neuron	PROPN
bam-4840	211	2	2004;42:387‐99	2004;42:387‐99	NUM
bam-4840	211	3	.	.	PROPN
bam-4840	211	4	36	36	NUM
bam-4840	211	5	.	.	PUNCT
bam-4840	212	1	casarotto	casarotto	VERB
bam-4840	212	2	mg	mg	PROPN
bam-4840	212	3	,	,	PUNCT
bam-4840	212	4	cui	cui	VERB
bam-4840	212	5	y	y	PROPN
bam-4840	212	6	,	,	PUNCT
bam-4840	212	7	karunasekara	karunasekara	PROPN
bam-4840	212	8	y	y	PROPN
bam-4840	212	9	,	,	PUNCT
bam-4840	212	10	et	et	PROPN
bam-4840	212	11	al	al	PROPN
bam-4840	212	12	.	.	PROPN
bam-4840	213	1	structural	structural	ADJ
bam-4840	213	2	and	and	CCONJ
bam-4840	213	3	functional	functional	ADJ
bam-4840	213	4	characterization	characterization	NOUN
bam-4840	213	5	of	of	ADP
bam-4840	213	6	interactions	interaction	NOUN
bam-4840	213	7	between	between	ADP
bam-4840	213	8	the	the	DET
bam-4840	213	9	dihydropyridine	dihydropyridine	NOUN
bam-4840	213	10	receptor	receptor	NOUN
bam-4840	213	11	ii‐iii	ii‐iii	PROPN
bam-4840	213	12	loop	loop	NOUN
bam-4840	213	13	and	and	CCONJ
bam-4840	213	14	the	the	DET
bam-4840	213	15	ryanodine	ryanodine	NOUN
bam-4840	213	16	receptor	receptor	NOUN
bam-4840	213	17	.	.	PUNCT
bam-4840	214	1	clin	clin	PROPN
bam-4840	214	2	exp	exp	NOUN
bam-4840	214	3	pharmacol	pharmacol	PROPN
bam-4840	214	4	physiol	physiol	PROPN
bam-4840	214	5	2006;33:1114‐7	2006;33:1114‐7	NUM
bam-4840	214	6	.	.	PUNCT
bam-4840	215	1	37	37	NUM
bam-4840	215	2	.	.	PUNCT
bam-4840	216	1	nakai	nakai	PROPN
bam-4840	216	2	j	j	PROPN
bam-4840	216	3	,	,	PUNCT
bam-4840	216	4	tanabe	tanabe	PROPN
bam-4840	216	5	t	t	PROPN
bam-4840	216	6	,	,	PUNCT
bam-4840	216	7	konno	konno	PROPN
bam-4840	216	8	t	t	PROPN
bam-4840	216	9	,	,	PUNCT
bam-4840	216	10	et	et	PROPN
bam-4840	216	11	al	al	PROPN
bam-4840	216	12	.	.	PUNCT
bam-4840	216	13	localization	localization	NOUN
bam-4840	216	14	in	in	ADP
bam-4840	216	15	the	the	DET
bam-4840	216	16	ii‐iii	ii‐iii	PROPN
bam-4840	216	17	loop	loop	NOUN
bam-4840	216	18	of	of	ADP
bam-4840	216	19	the	the	DET
bam-4840	216	20	dihydropyridine	dihydropyridine	NOUN
bam-4840	216	21	receptor	receptor	NOUN
bam-4840	216	22	of	of	ADP
bam-4840	216	23	a	a	DET
bam-4840	216	24	sequence	sequence	NOUN
bam-4840	216	25	critical	critical	ADJ
bam-4840	216	26	for	for	ADP
bam-4840	216	27	excitation‐contraction	excitation‐contraction	NOUN
bam-4840	216	28	coupling	coupling	NOUN
bam-4840	216	29	.	.	PUNCT
bam-4840	217	1	j	j	PROPN
bam-4840	217	2	biol	biol	PROPN
bam-4840	217	3	chem	chem	NOUN
bam-4840	217	4	1998;273:24983‐6	1998;273:24983‐6	NUM
bam-4840	217	5	.	.	PROPN
bam-4840	218	1	38	38	NUM
bam-4840	218	2	.	.	PUNCT
bam-4840	219	1	bannister	bannister	PROPN
bam-4840	219	2	ra	ra	PROPN
bam-4840	219	3	,	,	PUNCT
bam-4840	219	4	grabner	grabner	NOUN
bam-4840	219	5	m	m	PROPN
bam-4840	219	6	,	,	PUNCT
bam-4840	219	7	beam	beam	NOUN
bam-4840	219	8	kg	kg	PROPN
bam-4840	219	9	.	.	PUNCT
bam-4840	220	1	the	the	DET
bam-4840	220	2	alpha(1s	alpha(1s	PROPN
bam-4840	220	3	)	)	PUNCT
bam-4840	220	4	iii‐iv	iii‐iv	ADP
bam-4840	220	5	loop	loop	NOUN
bam-4840	220	6	influences	influence	NOUN
bam-4840	220	7	1,4‐dihydropyridine	1,4‐dihydropyridine	NUM
bam-4840	220	8	receptor	receptor	NOUN
bam-4840	220	9	gating	gate	VERB
bam-4840	220	10	but	but	CCONJ
bam-4840	220	11	is	be	AUX
bam-4840	220	12	not	not	PART
bam-4840	220	13	directly	directly	ADV
bam-4840	220	14	involved	involve	VERB
bam-4840	220	15	in	in	ADP
bam-4840	220	16	excitation‐coupling	excitation‐couple	VERB
bam-4840	220	17	interactions	interaction	NOUN
bam-4840	220	18	with	with	ADP
bam-4840	220	19	the	the	DET
bam-4840	220	20	type	type	NOUN
bam-4840	220	21	1	1	NUM
bam-4840	220	22	ryanodine	ryanodine	NOUN
bam-4840	220	23	receptor	receptor	NOUN
bam-4840	220	24	.	.	PUNCT
bam-4840	221	1	j	j	PROPN
bam-4840	221	2	biol	biol	PROPN
bam-4840	221	3	chem	chem	NOUN
bam-4840	221	4	2008;283:23217‐23	2008;283:23217‐23	NUM
bam-4840	221	5	.	.	PUNCT
bam-4840	222	1	3d	3d	NUM
bam-4840	222	2	structure	structure	NOUN
bam-4840	222	3	of	of	ADP
bam-4840	222	4	muscle	muscle	NOUN
bam-4840	222	5	dihydropyridine	dihydropyridine	NOUN
bam-4840	222	6	receptor	receptor	PROPN
bam-4840	222	7	eur	eur	PROPN
bam-4840	222	8	j	j	PROPN
bam-4840	222	9	transl	transl	PROPN
bam-4840	222	10	myol	myol	PROPN
bam-4840	222	11	basic	basic	ADJ
bam-4840	222	12	appl	appl	NOUN
bam-4840	222	13	myol	myol	NOUN
bam-4840	222	14	2015	2015	NUM
bam-4840	222	15	;	;	PUNCT
bam-4840	222	16	25	25	NUM
bam-4840	222	17	(	(	PUNCT
bam-4840	222	18	1	1	NUM
bam-4840	222	19	):	):	PUNCT
bam-4840	222	20	27	27	NUM
bam-4840	222	21	-	-	SYM
bam-4840	222	22	33	33	NUM
bam-4840	222	23	33	33	NUM
bam-4840	222	24	39	39	NUM
bam-4840	222	25	.	.	PUNCT
bam-4840	223	1	hulme	hulme	PROPN
bam-4840	223	2	jt	jt	PROPN
bam-4840	223	3	,	,	PUNCT
bam-4840	223	4	konoki	konoki	PROPN
bam-4840	223	5	k	k	PROPN
bam-4840	223	6	,	,	PUNCT
bam-4840	223	7	lin	lin	PROPN
bam-4840	223	8	tw	tw	PROPN
bam-4840	223	9	,	,	PUNCT
bam-4840	223	10	et	et	PROPN
bam-4840	223	11	al	al	PROPN
bam-4840	223	12	.	.	PUNCT
bam-4840	224	1	sites	site	NOUN
bam-4840	224	2	of	of	ADP
bam-4840	224	3	proteolytic	proteolytic	ADJ
bam-4840	224	4	processing	processing	NOUN
bam-4840	224	5	and	and	CCONJ
bam-4840	224	6	noncovalent	noncovalent	NOUN
bam-4840	224	7	association	association	NOUN
bam-4840	224	8	of	of	ADP
bam-4840	224	9	the	the	DET
bam-4840	224	10	distal	distal	ADJ
bam-4840	224	11	c‐terminal	c‐terminal	PROPN
bam-4840	224	12	domain	domain	NOUN
bam-4840	224	13	of	of	ADP
bam-4840	224	14	cav1.1	cav1.1	NOUN
bam-4840	224	15	channels	channel	NOUN
bam-4840	224	16	in	in	ADP
bam-4840	224	17	skeletal	skeletal	ADJ
bam-4840	224	18	muscle	muscle	NOUN
bam-4840	224	19	.	.	PUNCT
bam-4840	225	1	proc	proc	PROPN
bam-4840	225	2	natl	natl	PROPN
bam-4840	225	3	acad	acad	PROPN
bam-4840	225	4	sci	sci	PROPN
bam-4840	225	5	u	u	PROPN
bam-4840	225	6	s	s	PROPN
bam-4840	225	7	a	a	DET
bam-4840	225	8	2005;102:5274‐9	2005;102:5274‐9	NUM
bam-4840	225	9	.	.	PUNCT
bam-4840	226	1	40	40	NUM
bam-4840	226	2	.	.	X
bam-4840	226	3	de	de	PROPN
bam-4840	226	4	jongh	jongh	PROPN
bam-4840	226	5	ks	ks	PROPN
bam-4840	226	6	,	,	PUNCT
bam-4840	226	7	warner	warner	PROPN
bam-4840	226	8	c	c	PROPN
bam-4840	226	9	,	,	PUNCT
bam-4840	226	10	catterall	catterall	PROPN
bam-4840	226	11	wa	wa	PROPN
bam-4840	226	12	.	.	PROPN
bam-4840	226	13	subunits	subunit	NOUN
bam-4840	226	14	of	of	ADP
bam-4840	226	15	purified	purified	ADJ
bam-4840	226	16	calcium	calcium	NOUN
bam-4840	226	17	channels	channel	NOUN
bam-4840	226	18	.	.	PUNCT
bam-4840	227	1	alpha	alpha	NOUN
bam-4840	227	2	2	2	NUM
bam-4840	227	3	and	and	CCONJ
bam-4840	227	4	delta	delta	NOUN
bam-4840	227	5	are	be	AUX
bam-4840	227	6	encoded	encode	VERB
bam-4840	227	7	by	by	ADP
bam-4840	227	8	the	the	DET
bam-4840	227	9	same	same	ADJ
bam-4840	227	10	gene	gene	NOUN
bam-4840	227	11	.	.	PUNCT
bam-4840	228	1	j	j	PROPN
bam-4840	228	2	biol	biol	PROPN
bam-4840	228	3	chem	chem	NOUN
bam-4840	228	4	1990;265:14738‐41	1990;265:14738‐41	NUM
bam-4840	228	5	.	.	PROPN
bam-4840	228	6	41	41	NUM
bam-4840	228	7	.	.	PUNCT
bam-4840	229	1	arikkath	arikkath	PROPN
bam-4840	229	2	j	j	PROPN
bam-4840	229	3	,	,	PUNCT
bam-4840	229	4	chen	chen	PROPN
bam-4840	229	5	cc	cc	PROPN
bam-4840	229	6	,	,	PUNCT
bam-4840	229	7	ahern	ahern	PROPN
bam-4840	229	8	c	c	PROPN
bam-4840	229	9	,	,	PUNCT
bam-4840	229	10	allamand	allamand	NOUN
bam-4840	229	11	,	,	PUNCT
bam-4840	229	12	v	v	NOUN
bam-4840	229	13	et	et	PROPN
bam-4840	229	14	al	al	PROPN
bam-4840	229	15	.	.	PROPN
bam-4840	230	1	gamma	gamma	PROPN
bam-4840	230	2	1	1	NUM
bam-4840	230	3	subunit	subunit	NOUN
bam-4840	230	4	interactions	interaction	NOUN
bam-4840	230	5	the	the	DET
bam-4840	230	6	skeletal	skeletal	ADJ
bam-4840	230	7	muscle	muscle	NOUN
bam-4840	230	8	l‐type	l‐type	PUNCT
bam-4840	230	9	voltage‐gated	voltage‐gate	VERB
bam-4840	230	10	calcium	calcium	NOUN
bam-4840	230	11	channels	channel	NOUN
bam-4840	230	12	.	.	PUNCT
bam-4840	231	1	j	j	PROPN
bam-4840	231	2	biol	biol	PROPN
bam-4840	231	3	chem	chem	PROPN
bam-4840	231	4	2003;278:1212‐9	2003;278:1212‐9	NUM
bam-4840	231	5	.	.	PUNCT
bam-4840	232	1	42	42	NUM
bam-4840	232	2	.	.	PUNCT
bam-4840	233	1	gregg	gregg	PROPN
bam-4840	233	2	rg	rg	PROPN
bam-4840	233	3	,	,	PUNCT
bam-4840	233	4	messing	mess	VERB
bam-4840	233	5	a	a	DET
bam-4840	233	6	,	,	PUNCT
bam-4840	233	7	strube	strube	NOUN
bam-4840	233	8	c	c	NOUN
bam-4840	233	9	,	,	PUNCT
bam-4840	233	10	et	et	PROPN
bam-4840	233	11	al	al	PROPN
bam-4840	233	12	.	.	PROPN
bam-4840	234	1	absence	absence	NOUN
bam-4840	234	2	of	of	ADP
bam-4840	234	3	the	the	DET
bam-4840	234	4	beta	beta	ADJ
bam-4840	234	5	subunit	subunit	NOUN
bam-4840	234	6	(	(	PUNCT
bam-4840	234	7	cchb1	cchb1	NOUN
bam-4840	234	8	)	)	PUNCT
bam-4840	234	9	of	of	ADP
bam-4840	234	10	the	the	DET
bam-4840	234	11	skeletal	skeletal	ADJ
bam-4840	234	12	muscle	muscle	NOUN
bam-4840	234	13	dihydropyridine	dihydropyridine	NOUN
bam-4840	234	14	receptor	receptor	NOUN
bam-4840	234	15	alters	alter	VERB
bam-4840	234	16	expression	expression	NOUN
bam-4840	234	17	of	of	ADP
bam-4840	234	18	the	the	DET
bam-4840	234	19	alpha	alpha	NOUN
bam-4840	234	20	1	1	NUM
bam-4840	234	21	subunit	subunit	NOUN
bam-4840	234	22	and	and	CCONJ
bam-4840	234	23	eliminates	eliminate	NOUN
bam-4840	234	24	excitation‐	excitation‐	ADP
bam-4840	234	25	contraction	contraction	NOUN
bam-4840	234	26	coupling	coupling	NOUN
bam-4840	234	27	.	.	PUNCT
bam-4840	235	1	proc	proc	PROPN
bam-4840	235	2	natl	natl	PROPN
bam-4840	235	3	acad	acad	PROPN
bam-4840	235	4	sci	sci	PROPN
bam-4840	235	5	u	u	PROPN
bam-4840	235	6	s	s	PROPN
bam-4840	235	7	a	a	DET
bam-4840	235	8	1996;93:13961‐6	1996;93:13961‐6	NUM
bam-4840	235	9	.	.	PUNCT
bam-4840	235	10	43	43	NUM
bam-4840	235	11	.	.	PUNCT
bam-4840	236	1	cabra	cabra	PROPN
bam-4840	236	2	v	v	PROPN
bam-4840	236	3	,	,	PUNCT
bam-4840	236	4	samso	samso	ADJ
bam-4840	236	5	m.	m.	NOUN
bam-4840	236	6	do	do	VERB
bam-4840	236	7	's	's	PART
bam-4840	236	8	and	and	CCONJ
bam-4840	236	9	don'ts	don't	NOUN
bam-4840	236	10	of	of	ADP
bam-4840	236	11	cryo‐electron	cryo‐electron	PROPN
bam-4840	236	12	microscopy	microscopy	NOUN
bam-4840	236	13	:	:	PUNCT
bam-4840	236	14	a	a	DET
bam-4840	236	15	primer	primer	NOUN
bam-4840	236	16	on	on	ADP
bam-4840	236	17	sample	sample	NOUN
bam-4840	236	18	preparation	preparation	NOUN
bam-4840	236	19	and	and	CCONJ
bam-4840	236	20	high	high	ADJ
bam-4840	236	21	quality	quality	NOUN
bam-4840	236	22	data	datum	NOUN
bam-4840	236	23	collection	collection	NOUN
bam-4840	236	24	for	for	ADP
bam-4840	236	25	macromolecular	macromolecular	NOUN
bam-4840	236	26	3d	3d	PROPN
bam-4840	236	27	reconstruction	reconstruction	NOUN
bam-4840	236	28	.	.	PUNCT
bam-4840	237	1	j	j	PROPN
bam-4840	237	2	vis	vis	X
bam-4840	237	3	exp	exp	PROPN
bam-4840	237	4	2015;95	2015;95	NUM
bam-4840	237	5	:	:	PUNCT
bam-4840	237	6	e52311	e52311	PROPN
bam-4840	237	7	.	.	PROPN
bam-4840	237	8	44	44	NUM
bam-4840	237	9	.	.	PUNCT
bam-4840	237	10	yan	yan	PROPN
bam-4840	238	1	z	z	PROPN
bam-4840	238	2	,	,	PUNCT
bam-4840	238	3	bai	bai	PROPN
bam-4840	238	4	x	x	PROPN
bam-4840	238	5	-	-	PUNCT
bam-4840	238	6	c	c	PROPN
bam-4840	238	7	,	,	PUNCT
bam-4840	238	8	yan	yan	PROPN
bam-4840	239	1	c	c	X
bam-4840	239	2	,	,	PUNCT
bam-4840	239	3	et	et	PROPN
bam-4840	239	4	al	al	PROPN
bam-4840	239	5	.	.	PUNCT
bam-4840	239	6	structure	structure	NOUN
bam-4840	239	7	of	of	ADP
bam-4840	239	8	the	the	DET
bam-4840	239	9	rabbit	rabbit	NOUN
bam-4840	239	10	ryanodine	ryanodine	NOUN
bam-4840	239	11	receptor	receptor	NOUN
bam-4840	239	12	ryr1	ryr1	NOUN
bam-4840	239	13	at	at	ADP
bam-4840	239	14	near	near	ADJ
bam-4840	239	15	-	-	PUNCT
bam-4840	239	16	atomic	atomic	ADJ
bam-4840	239	17	resolution	resolution	NOUN
bam-4840	239	18	.	.	PUNCT
bam-4840	240	1	nature	nature	NOUN
bam-4840	240	2	2014;517:50	2014;517:50	NUM
bam-4840	240	3	-	-	SYM
bam-4840	240	4	5	5	NUM
bam-4840	240	5	.	.	PUNCT