id	sid	tid	token	lemma	pos
bam-5830	1	1	bam	bam	VERB
bam-5830	1	2	12	12	NUM
bam-5830	1	3	(	(	PUNCT
bam-5830	1	4	1	1	NUM
bam-5830	1	5	)	)	PUNCT
bam-5830	1	6	2002	2002	NUM
bam-5830	1	7	abstracts	abstract	NOUN
bam-5830	1	8	of	of	ADP
bam-5830	1	9	the	the	DET
bam-5830	1	10	xii	xii	PROPN
bam-5830	1	11	iim	iim	NOUN
bam-5830	1	12	myology	myology	NOUN
bam-5830	1	13	meeting	meeting	NOUN
bam-5830	1	14	october	october	PROPN
bam-5830	1	15	1–4	1–4	PROPN
bam-5830	1	16	,	,	PUNCT
bam-5830	1	17	2015	2015	NUM
bam-5830	2	1	eur	eur	PROPN
bam-5830	2	2	j	j	PROPN
bam-5830	2	3	transl	transl	PROPN
bam-5830	2	4	myol	myol	PROPN
bam-5830	2	5	basic	basic	ADJ
bam-5830	2	6	appl	appl	NOUN
bam-5830	2	7	myol	myol	NOUN
bam-5830	2	8	2016	2016	NUM
bam-5830	2	9	;	;	PUNCT
bam-5830	2	10	26	26	NUM
bam-5830	2	11	(	(	PUNCT
bam-5830	2	12	1):2	1):2	NUM
bam-5830	2	13	-	-	SYM
bam-5830	2	14	24	24	NUM
bam-5830	2	15	this	this	DET
bam-5830	2	16	article	article	NOUN
bam-5830	2	17	is	be	AUX
bam-5830	2	18	distributed	distribute	VERB
bam-5830	2	19	under	under	ADP
bam-5830	2	20	the	the	DET
bam-5830	2	21	terms	term	NOUN
bam-5830	2	22	of	of	ADP
bam-5830	2	23	the	the	DET
bam-5830	2	24	creative	creative	ADJ
bam-5830	2	25	commons	common	NOUN
bam-5830	2	26	attribution	attribution	NOUN
bam-5830	2	27	noncommercial	noncommercial	ADJ
bam-5830	2	28	license	license	NOUN
bam-5830	2	29	(	(	PUNCT
bam-5830	2	30	cc	cc	NOUN
bam-5830	2	31	by	by	ADP
bam-5830	2	32	-	-	PUNCT
bam-5830	2	33	nc	nc	PROPN
bam-5830	2	34	4.0	4.0	NUM
bam-5830	2	35	)	)	PUNCT
bam-5830	2	36	which	which	PRON
bam-5830	2	37	permits	permit	VERB
bam-5830	2	38	any	any	DET
bam-5830	2	39	noncommercial	noncommercial	ADJ
bam-5830	2	40	use	use	NOUN
bam-5830	2	41	,	,	PUNCT
bam-5830	2	42	distribution	distribution	NOUN
bam-5830	2	43	,	,	PUNCT
bam-5830	2	44	and	and	CCONJ
bam-5830	2	45	reproduction	reproduction	NOUN
bam-5830	2	46	in	in	ADP
bam-5830	2	47	any	any	DET
bam-5830	2	48	medium	medium	NOUN
bam-5830	2	49	,	,	PUNCT
bam-5830	2	50	provided	provide	VERB
bam-5830	2	51	the	the	DET
bam-5830	2	52	original	original	ADJ
bam-5830	2	53	author(s	author(s	NOUN
bam-5830	2	54	)	)	PUNCT
bam-5830	2	55	and	and	CCONJ
bam-5830	2	56	source	source	NOUN
bam-5830	2	57	are	be	AUX
bam-5830	2	58	credited	credit	VERB
bam-5830	2	59	.	.	PUNCT
bam-5830	3	1	2	2	NUM
bam-5830	3	2	abstracts	abstract	NOUN
bam-5830	3	3	of	of	ADP
bam-5830	3	4	the	the	DET
bam-5830	3	5	xii	xii	PROPN
bam-5830	3	6	iim	iim	NOUN
bam-5830	3	7	myology	myology	NOUN
bam-5830	3	8	meeting	meeting	NOUN
bam-5830	3	9	october	october	PROPN
bam-5830	3	10	1–4	1–4	PROPN
bam-5830	3	11	,	,	PUNCT
bam-5830	3	12	2015	2015	NUM
bam-5830	3	13	eur	eur	PROPN
bam-5830	3	14	j	j	PROPN
bam-5830	3	15	transl	transl	PROPN
bam-5830	3	16	myol	myol	PROPN
bam-5830	3	17	basic	basic	ADJ
bam-5830	3	18	appl	appl	NOUN
bam-5830	3	19	myol	myol	NOUN
bam-5830	3	20	2016	2016	NUM
bam-5830	3	21	;	;	PUNCT
bam-5830	3	22	26	26	NUM
bam-5830	3	23	(	(	PUNCT
bam-5830	3	24	1):2	1):2	NUM
bam-5830	3	25	-	-	SYM
bam-5830	3	26	24	24	NUM
bam-5830	3	27	this	this	DET
bam-5830	3	28	article	article	NOUN
bam-5830	3	29	is	be	AUX
bam-5830	3	30	distributed	distribute	VERB
bam-5830	3	31	under	under	ADP
bam-5830	3	32	the	the	DET
bam-5830	3	33	terms	term	NOUN
bam-5830	3	34	of	of	ADP
bam-5830	3	35	the	the	DET
bam-5830	3	36	creative	creative	ADJ
bam-5830	3	37	commons	common	NOUN
bam-5830	3	38	attribution	attribution	NOUN
bam-5830	3	39	noncommercial	noncommercial	ADJ
bam-5830	3	40	license	license	NOUN
bam-5830	3	41	(	(	PUNCT
bam-5830	3	42	cc	cc	NOUN
bam-5830	3	43	by	by	ADP
bam-5830	3	44	-	-	PUNCT
bam-5830	3	45	nc	nc	PROPN
bam-5830	3	46	4.0	4.0	NUM
bam-5830	3	47	)	)	PUNCT
bam-5830	3	48	which	which	PRON
bam-5830	3	49	permits	permit	VERB
bam-5830	3	50	any	any	DET
bam-5830	3	51	noncommercial	noncommercial	ADJ
bam-5830	3	52	use	use	NOUN
bam-5830	3	53	,	,	PUNCT
bam-5830	3	54	distribution	distribution	NOUN
bam-5830	3	55	,	,	PUNCT
bam-5830	3	56	and	and	CCONJ
bam-5830	3	57	reproduction	reproduction	NOUN
bam-5830	3	58	in	in	ADP
bam-5830	3	59	any	any	DET
bam-5830	3	60	medium	medium	NOUN
bam-5830	3	61	,	,	PUNCT
bam-5830	3	62	provided	provide	VERB
bam-5830	3	63	the	the	DET
bam-5830	3	64	original	original	ADJ
bam-5830	3	65	author(s	author(s	NOUN
bam-5830	3	66	)	)	PUNCT
bam-5830	3	67	and	and	CCONJ
bam-5830	3	68	source	source	NOUN
bam-5830	3	69	are	be	AUX
bam-5830	3	70	credited	credit	VERB
bam-5830	3	71	.	.	PUNCT
bam-5830	4	1	3	3	NUM
bam-5830	4	2	session	session	NOUN
bam-5830	4	3	1	1	NUM
bam-5830	4	4	.	.	PUNCT
bam-5830	4	5	satellite	satellite	NOUN
bam-5830	4	6	cells	cell	NOUN
bam-5830	4	7	and	and	CCONJ
bam-5830	4	8	muscle	muscle	NOUN
bam-5830	4	9	regeneration	regeneration	NOUN
bam-5830	4	10	in	in	ADP
bam-5830	4	11	healthy	healthy	ADJ
bam-5830	4	12	muscle	muscle	NOUN
bam-5830	4	13	and	and	CCONJ
bam-5830	4	14	in	in	ADP
bam-5830	4	15	dystrophies	dystrophy	NOUN
bam-5830	4	16	/	/	SYM
bam-5830	4	17	myopathies	myopathy	NOUN
bam-5830	4	18	s100b	s100b	PROPN
bam-5830	4	19	protein	protein	NOUN
bam-5830	4	20	in	in	ADP
bam-5830	4	21	skeletal	skeletal	ADJ
bam-5830	4	22	muscle	muscle	NOUN
bam-5830	4	23	regeneration	regeneration	NOUN
bam-5830	4	24	:	:	PUNCT
bam-5830	4	25	regulation	regulation	NOUN
bam-5830	4	26	of	of	ADP
bam-5830	4	27	myoblast	myoblast	ADJ
bam-5830	4	28	and	and	CCONJ
bam-5830	4	29	macrophage	macrophage	ADJ
bam-5830	4	30	functions	function	NOUN
bam-5830	4	31	f.	f.	PROPN
bam-5830	4	32	riuzzi	riuzzi	PROPN
bam-5830	4	33	,	,	PUNCT
bam-5830	4	34	s.	s.	PROPN
bam-5830	4	35	beccafico	beccafico	PROPN
bam-5830	4	36	,	,	PUNCT
bam-5830	4	37	g.	g.	PROPN
bam-5830	4	38	sorci	sorci	PROPN
bam-5830	4	39	,	,	PUNCT
bam-5830	4	40	r.	r.	PROPN
bam-5830	4	41	donato	donato	PROPN
bam-5830	4	42	department	department	PROPN
bam-5830	4	43	of	of	ADP
bam-5830	4	44	experimental	experimental	ADJ
bam-5830	4	45	medicine	medicine	NOUN
bam-5830	4	46	,	,	PUNCT
bam-5830	4	47	section	section	NOUN
bam-5830	4	48	of	of	ADP
bam-5830	4	49	anatomy	anatomy	NOUN
bam-5830	4	50	,	,	PUNCT
bam-5830	4	51	university	university	PROPN
bam-5830	4	52	of	of	ADP
bam-5830	4	53	perugia	perugia	PROPN
bam-5830	4	54	,	,	PUNCT
bam-5830	4	55	italy	italy	PROPN
bam-5830	4	56	e	e	PROPN
bam-5830	4	57	-	-	NOUN
bam-5830	4	58	mail	mail	NOUN
bam-5830	4	59	:	:	PUNCT
bam-5830	4	60	f.riuzzi@email.it	f.riuzzi@email.it	X
bam-5830	4	61	repair	repair	NOUN
bam-5830	4	62	of	of	ADP
bam-5830	4	63	damaged	damage	VERB
bam-5830	4	64	muscle	muscle	NOUN
bam-5830	4	65	tissue	tissue	NOUN
bam-5830	4	66	upon	upon	SCONJ
bam-5830	4	67	acute	acute	ADJ
bam-5830	4	68	injury	injury	NOUN
bam-5830	4	69	requires	require	VERB
bam-5830	4	70	the	the	DET
bam-5830	4	71	coordinated	coordinated	ADJ
bam-5830	4	72	action	action	NOUN
bam-5830	4	73	of	of	ADP
bam-5830	4	74	infiltrating	infiltrate	VERB
bam-5830	4	75	inflammatory	inflammatory	ADJ
bam-5830	4	76	cells	cell	NOUN
bam-5830	4	77	and	and	CCONJ
bam-5830	4	78	activated	activate	VERB
bam-5830	4	79	muscle	muscle	NOUN
bam-5830	4	80	stem	stem	NOUN
bam-5830	4	81	cells	cell	NOUN
bam-5830	4	82	known	know	VERB
bam-5830	4	83	as	as	ADP
bam-5830	4	84	satellite	satellite	NOUN
bam-5830	4	85	cells	cell	NOUN
bam-5830	4	86	to	to	PART
bam-5830	4	87	restore	restore	VERB
bam-5830	4	88	homeostasis	homeostasis	NOUN
bam-5830	4	89	.	.	PUNCT
bam-5830	5	1	s100b	s100b	PROPN
bam-5830	5	2	protein	protein	NOUN
bam-5830	5	3	regulates	regulate	VERB
bam-5830	5	4	myoblast	myoblast	ADJ
bam-5830	5	5	proliferation	proliferation	NOUN
bam-5830	5	6	and	and	CCONJ
bam-5830	5	7	differentiation	differentiation	NOUN
bam-5830	5	8	,	,	PUNCT
bam-5830	5	9	and	and	CCONJ
bam-5830	5	10	its	its	PRON
bam-5830	5	11	effects	effect	NOUN
bam-5830	5	12	depend	depend	VERB
bam-5830	5	13	on	on	ADP
bam-5830	5	14	its	its	PRON
bam-5830	5	15	concentration	concentration	NOUN
bam-5830	5	16	,	,	PUNCT
bam-5830	5	17	the	the	DET
bam-5830	5	18	myoblast	myoblast	ADJ
bam-5830	5	19	density	density	NOUN
bam-5830	5	20	,	,	PUNCT
bam-5830	5	21	the	the	DET
bam-5830	5	22	presence	presence	NOUN
bam-5830	5	23	of	of	ADP
bam-5830	5	24	bfgf	bfgf	NOUN
bam-5830	5	25	,	,	PUNCT
bam-5830	5	26	and	and	CCONJ
bam-5830	5	27	the	the	DET
bam-5830	5	28	duration	duration	NOUN
bam-5830	5	29	of	of	ADP
bam-5830	5	30	exposure	exposure	NOUN
bam-5830	5	31	of	of	ADP
bam-5830	5	32	myoblasts	myoblast	NOUN
bam-5830	5	33	to	to	ADP
bam-5830	5	34	the	the	DET
bam-5830	5	35	protein	protein	NOUN
bam-5830	5	36	(	(	PUNCT
bam-5830	5	37	1,2	1,2	NUM
bam-5830	5	38	)	)	PUNCT
bam-5830	5	39	.	.	PUNCT
bam-5830	6	1	s100b	s100b	PROPN
bam-5830	6	2	is	be	AUX
bam-5830	6	3	abundantly	abundantly	ADV
bam-5830	6	4	released	release	VERB
bam-5830	6	5	during	during	ADP
bam-5830	6	6	the	the	DET
bam-5830	6	7	first	first	ADJ
bam-5830	6	8	few	few	ADJ
bam-5830	6	9	days	day	NOUN
bam-5830	6	10	after	after	SCONJ
bam-5830	6	11	acute	acute	ADJ
bam-5830	6	12	muscle	muscle	NOUN
bam-5830	6	13	injury	injury	NOUN
bam-5830	6	14	and	and	CCONJ
bam-5830	6	15	its	its	PRON
bam-5830	6	16	release	release	NOUN
bam-5830	6	17	rapidly	rapidly	ADV
bam-5830	6	18	declines	decline	VERB
bam-5830	6	19	thereafter	thereafter	ADV
bam-5830	6	20	(	(	PUNCT
bam-5830	6	21	2	2	NUM
bam-5830	6	22	)	)	PUNCT
bam-5830	6	23	.	.	PUNCT
bam-5830	7	1	the	the	DET
bam-5830	7	2	role	role	NOUN
bam-5830	7	3	of	of	ADP
bam-5830	7	4	myofiber	myofiber	NOUN
bam-5830	7	5	-	-	PUNCT
bam-5830	7	6	released	release	VERB
bam-5830	7	7	s100b	s100b	PROPN
bam-5830	7	8	is	be	AUX
bam-5830	7	9	not	not	PART
bam-5830	7	10	known	know	VERB
bam-5830	7	11	.	.	PUNCT
bam-5830	8	1	here	here	ADV
bam-5830	8	2	we	we	PRON
bam-5830	8	3	report	report	VERB
bam-5830	8	4	that	that	SCONJ
bam-5830	8	5	following	follow	VERB
bam-5830	8	6	injury	injury	NOUN
bam-5830	8	7	with	with	ADP
bam-5830	8	8	bacl2	bacl2	NOUN
bam-5830	8	9	injection	injection	NOUN
bam-5830	8	10	myofiber	myofiber	NOUN
bam-5830	8	11	-	-	PUNCT
bam-5830	8	12	released	release	VERB
bam-5830	8	13	s100b	s100b	PROPN
bam-5830	8	14	expands	expand	VERB
bam-5830	8	15	the	the	DET
bam-5830	8	16	myoblast	myoblast	ADJ
bam-5830	8	17	population	population	NOUN
bam-5830	8	18	,	,	PUNCT
bam-5830	8	19	attracts	attract	VERB
bam-5830	8	20	macrophages	macrophage	NOUN
bam-5830	8	21	to	to	ADP
bam-5830	8	22	the	the	DET
bam-5830	8	23	site	site	NOUN
bam-5830	8	24	of	of	ADP
bam-5830	8	25	damage	damage	NOUN
bam-5830	8	26	,	,	PUNCT
bam-5830	8	27	and	and	CCONJ
bam-5830	8	28	promotes	promote	VERB
bam-5830	8	29	macrophage	macrophage	ADJ
bam-5830	8	30	polarization	polarization	NOUN
bam-5830	8	31	into	into	ADP
bam-5830	8	32	m2	m2	PROPN
bam-5830	8	33	(	(	PUNCT
bam-5830	8	34	proregenerative	proregenerative	ADJ
bam-5830	8	35	)	)	PUNCT
bam-5830	8	36	phenotype	phenotype	NOUN
bam-5830	8	37	.	.	PUNCT
bam-5830	9	1	also	also	ADV
bam-5830	9	2	,	,	PUNCT
bam-5830	9	3	s100b	s100b	PROPN
bam-5830	9	4	is	be	AUX
bam-5830	9	5	transiently	transiently	ADV
bam-5830	9	6	expressed	express	VERB
bam-5830	9	7	in	in	ADP
bam-5830	9	8	and	and	CCONJ
bam-5830	9	9	released	release	VERB
bam-5830	9	10	by	by	ADP
bam-5830	9	11	macrophages	macrophage	NOUN
bam-5830	9	12	in	in	ADP
bam-5830	9	13	response	response	NOUN
bam-5830	9	14	to	to	ADP
bam-5830	9	15	cytokines	cytokine	NOUN
bam-5830	9	16	.	.	PUNCT
bam-5830	10	1	s100b	s100b	PROPN
bam-5830	10	2	effects	effect	NOUN
bam-5830	10	3	are	be	AUX
bam-5830	10	4	mediated	mediate	VERB
bam-5830	10	5	by	by	ADP
bam-5830	10	6	rage	rage	NOUN
bam-5830	10	7	(	(	PUNCT
bam-5830	10	8	receptor	receptor	NOUN
bam-5830	10	9	for	for	ADP
bam-5830	10	10	advanced	advanced	ADJ
bam-5830	10	11	glycation	glycation	NOUN
bam-5830	10	12	end	end	NOUN
bam-5830	10	13	-	-	PUNCT
bam-5830	10	14	products	product	NOUN
bam-5830	10	15	)	)	PUNCT
bam-5830	10	16	in	in	ADP
bam-5830	10	17	the	the	DET
bam-5830	10	18	early	early	ADJ
bam-5830	10	19	phase	phase	NOUN
bam-5830	10	20	of	of	ADP
bam-5830	10	21	muscle	muscle	NOUN
bam-5830	10	22	regeneration	regeneration	NOUN
bam-5830	10	23	,	,	PUNCT
bam-5830	10	24	however	however	ADV
bam-5830	10	25	during	during	ADP
bam-5830	10	26	the	the	DET
bam-5830	10	27	myoblast	myoblast	ADJ
bam-5830	10	28	proliferation	proliferation	NOUN
bam-5830	10	29	phase	phase	NOUN
bam-5830	10	30	s100b	s100b	PROPN
bam-5830	10	31	also	also	ADV
bam-5830	10	32	activates	activate	VERB
bam-5830	10	33	the	the	DET
bam-5830	10	34	bfgf	bfgf	ADJ
bam-5830	10	35	-	-	PUNCT
bam-5830	10	36	fgfr1	fgfr1	NOUN
bam-5830	10	37	complex	complex	NOUN
bam-5830	10	38	to	to	PART
bam-5830	10	39	stimulate	stimulate	VERB
bam-5830	10	40	myoblast	myoblast	ADJ
bam-5830	10	41	proliferation	proliferation	NOUN
bam-5830	10	42	and	and	CCONJ
bam-5830	10	43	macrophage	macrophage	ADJ
bam-5830	10	44	m1	m1	NOUN
bam-5830	10	45	/	/	SYM
bam-5830	10	46	m2	m2	PROPN
bam-5830	10	47	transition	transition	NOUN
bam-5830	10	48	.	.	PUNCT
bam-5830	11	1	thus	thus	ADV
bam-5830	11	2	,	,	PUNCT
bam-5830	11	3	s100b	s100b	PROPN
bam-5830	11	4	controls	control	VERB
bam-5830	11	5	macrophage	macrophage	ADJ
bam-5830	11	6	phenotypic	phenotypic	ADJ
bam-5830	11	7	transition	transition	NOUN
bam-5830	11	8	and	and	CCONJ
bam-5830	11	9	myoblast	myoblast	ADJ
bam-5830	11	10	activity	activity	NOUN
bam-5830	11	11	following	follow	VERB
bam-5830	11	12	acute	acute	ADJ
bam-5830	11	13	muscle	muscle	NOUN
bam-5830	11	14	damage	damage	NOUN
bam-5830	11	15	.	.	PUNCT
bam-5830	12	1	our	our	PRON
bam-5830	12	2	data	data	NOUN
bam-5830	12	3	point	point	NOUN
bam-5830	12	4	to	to	ADP
bam-5830	12	5	s100b	s100b	PROPN
bam-5830	12	6	as	as	ADP
bam-5830	12	7	to	to	ADP
bam-5830	12	8	a	a	DET
bam-5830	12	9	physiological	physiological	ADJ
bam-5830	12	10	player	player	NOUN
bam-5830	12	11	required	require	VERB
bam-5830	12	12	for	for	ADP
bam-5830	12	13	correct	correct	ADJ
bam-5830	12	14	timing	timing	NOUN
bam-5830	12	15	of	of	ADP
bam-5830	12	16	skeletal	skeletal	ADJ
bam-5830	12	17	muscle	muscle	NOUN
bam-5830	12	18	regeneration	regeneration	NOUN
bam-5830	12	19	.	.	PUNCT
bam-5830	13	1	however	however	ADV
bam-5830	13	2	,	,	PUNCT
bam-5830	13	3	high	high	ADJ
bam-5830	13	4	amounts	amount	NOUN
bam-5830	13	5	of	of	ADP
bam-5830	13	6	s100b	s100b	PROPN
bam-5830	13	7	at	at	ADP
bam-5830	13	8	damage	damage	NOUN
bam-5830	13	9	sites	site	NOUN
bam-5830	13	10	early	early	ADV
bam-5830	13	11	after	after	ADP
bam-5830	13	12	injury	injury	NOUN
bam-5830	13	13	are	be	AUX
bam-5830	13	14	detrimental	detrimental	ADJ
bam-5830	13	15	causing	cause	VERB
bam-5830	13	16	prolongation	prolongation	NOUN
bam-5830	13	17	of	of	ADP
bam-5830	13	18	the	the	DET
bam-5830	13	19	myoblast	myoblast	ADJ
bam-5830	13	20	proliferation	proliferation	NOUN
bam-5830	13	21	phase	phase	NOUN
bam-5830	13	22	at	at	ADP
bam-5830	13	23	the	the	DET
bam-5830	13	24	expense	expense	NOUN
bam-5830	13	25	of	of	ADP
bam-5830	13	26	myoblast	myoblast	ADJ
bam-5830	13	27	differentiation	differentiation	NOUN
bam-5830	13	28	/	/	SYM
bam-5830	13	29	fusion	fusion	NOUN
bam-5830	13	30	,	,	PUNCT
bam-5830	13	31	larger	large	ADJ
bam-5830	13	32	infiltration	infiltration	NOUN
bam-5830	13	33	with	with	ADP
bam-5830	13	34	m1	m1	PROPN
bam-5830	13	35	macrophages	macrophage	NOUN
bam-5830	13	36	,	,	PUNCT
bam-5830	13	37	prolongation	prolongation	NOUN
bam-5830	13	38	of	of	ADP
bam-5830	13	39	the	the	DET
bam-5830	13	40	macrophage	macrophage	ADJ
bam-5830	13	41	m1	m1	NOUN
bam-5830	13	42	phase	phase	NOUN
bam-5830	13	43	,	,	PUNCT
bam-5830	13	44	and	and	CCONJ
bam-5830	13	45	deposition	deposition	NOUN
bam-5830	13	46	of	of	ADP
bam-5830	13	47	fibrotic	fibrotic	ADJ
bam-5830	13	48	tissue	tissue	NOUN
bam-5830	13	49	.	.	PUNCT
bam-5830	14	1	thus	thus	ADV
bam-5830	14	2	,	,	PUNCT
bam-5830	14	3	if	if	SCONJ
bam-5830	14	4	present	present	ADJ
bam-5830	14	5	in	in	ADP
bam-5830	14	6	high	high	ADJ
bam-5830	14	7	amounts	amount	NOUN
bam-5830	14	8	s100b	s100b	PROPN
bam-5830	14	9	might	might	AUX
bam-5830	14	10	contribute	contribute	VERB
bam-5830	14	11	to	to	ADP
bam-5830	14	12	the	the	DET
bam-5830	14	13	pathophysiology	pathophysiology	NOUN
bam-5830	14	14	of	of	ADP
bam-5830	14	15	muscle	muscle	NOUN
bam-5830	14	16	degenerative	degenerative	ADJ
bam-5830	14	17	diseases	disease	NOUN
bam-5830	14	18	characterized	characterize	VERB
bam-5830	14	19	by	by	ADP
bam-5830	14	20	chronic	chronic	ADJ
bam-5830	14	21	inflammation	inflammation	NOUN
bam-5830	14	22	and/or	and/or	CCONJ
bam-5830	14	23	deregulated	deregulate	VERB
bam-5830	14	24	muscle	muscle	NOUN
bam-5830	14	25	regeneration	regeneration	NOUN
bam-5830	14	26	.	.	PUNCT
bam-5830	15	1	1	1	X
bam-5830	15	2	.	.	X
bam-5830	15	3	riuzzi	riuzzi	NOUN
bam-5830	15	4	f.	f.	PROPN
bam-5830	15	5	et	et	PROPN
bam-5830	15	6	al	al	PROPN
bam-5830	15	7	.	.	PROPN
bam-5830	15	8	,	,	PUNCT
bam-5830	15	9	j.	j.	PROPN
bam-5830	15	10	cell	cell	PROPN
bam-5830	15	11	sci	sci	PROPN
bam-5830	15	12	2011;124:2389	2011;124:2389	NUM
bam-5830	15	13	-	-	SYM
bam-5830	15	14	400	400	NUM
bam-5830	15	15	.	.	PUNCT
bam-5830	16	1	2	2	NUM
bam-5830	16	2	.	.	X
bam-5830	16	3	riuzzi	riuzzi	NOUN
bam-5830	16	4	f.	f.	PROPN
bam-5830	16	5	et	et	PROPN
bam-5830	16	6	al	al	PROPN
bam-5830	16	7	.	.	PROPN
bam-5830	16	8	,	,	PUNCT
bam-5830	16	9	plos	plos	PROPN
bam-5830	16	10	one	one	NUM
bam-5830	16	11	2012	2012	NUM
bam-5830	16	12	;	;	PUNCT
bam-5830	16	13	7	7	NUM
bam-5830	16	14	:	:	PUNCT
bam-5830	16	15	e28700	e28700	NOUN
bam-5830	16	16	.	.	PUNCT
bam-5830	17	1	*	*	PUNCT
bam-5830	17	2	*	*	PUNCT
bam-5830	17	3	*	*	PUNCT
bam-5830	17	4	*	*	PUNCT
bam-5830	17	5	*	*	PUNCT
bam-5830	17	6	phosphorylation	phosphorylation	NOUN
bam-5830	17	7	and	and	CCONJ
bam-5830	17	8	alternative	alternative	ADJ
bam-5830	17	9	splicing	splicing	NOUN
bam-5830	17	10	of	of	ADP
bam-5830	17	11	mef2c	mef2c	PROPN
bam-5830	17	12	,	,	PUNCT
bam-5830	17	13	a	a	DET
bam-5830	17	14	dual	dual	ADJ
bam-5830	17	15	switch	switch	NOUN
bam-5830	17	16	function	function	NOUN
bam-5830	17	17	in	in	ADP
bam-5830	17	18	muscle	muscle	NOUN
bam-5830	17	19	regeneration	regeneration	NOUN
bam-5830	17	20	f.	f.	PROPN
bam-5830	17	21	baruffaldi	baruffaldi	PROPN
bam-5830	17	22	1	1	NUM
bam-5830	17	23	,	,	PUNCT
bam-5830	17	24	s.	s.	PROPN
bam-5830	17	25	badodi	badodi	VERB
bam-5830	17	26	1	1	NUM
bam-5830	17	27	,	,	PUNCT
bam-5830	17	28	l.	l.	PROPN
bam-5830	17	29	de	de	X
bam-5830	17	30	feo	feo	PROPN
bam-5830	17	31	1	1	NUM
bam-5830	17	32	,	,	PUNCT
bam-5830	17	33	m.	m.	NOUN
bam-5830	17	34	ganassi	ganassi	PROPN
bam-5830	17	35	2	2	NUM
bam-5830	17	36	,	,	PUNCT
bam-5830	17	37	r.	r.	PROPN
bam-5830	17	38	battini	battini	PROPN
bam-5830	17	39	1	1	NUM
bam-5830	17	40	,	,	PUNCT
bam-5830	17	41	c.	c.	PROPN
bam-5830	17	42	imbriano	imbriano	PROPN
bam-5830	17	43	1	1	NUM
bam-5830	17	44	,	,	PUNCT
bam-5830	17	45	c.	c.	PROPN
bam-5830	17	46	nicoletti	nicoletti	PROPN
bam-5830	17	47	3	3	NUM
bam-5830	17	48	,	,	PUNCT
bam-5830	17	49	a.	a.	NOUN
bam-5830	17	50	musarò	musarò	NOUN
bam-5830	17	51	3	3	NUM
bam-5830	17	52	,	,	PUNCT
bam-5830	17	53	m.	m.	NOUN
bam-5830	17	54	buckingham	buckingham	PROPN
bam-5830	17	55	4	4	NUM
bam-5830	17	56	,	,	PUNCT
bam-5830	17	57	d.	d.	PROPN
bam-5830	17	58	montarras	montarras	PROPN
bam-5830	17	59	4	4	NUM
bam-5830	17	60	,	,	PUNCT
bam-5830	17	61	s.	s.	PROPN
bam-5830	17	62	molinari	molinari	PROPN
bam-5830	17	63	1	1	NUM
bam-5830	17	64	1	1	NUM
bam-5830	17	65	.	.	X
bam-5830	17	66	dipartimento	dipartimento	ADP
bam-5830	17	67	di	di	PROPN
bam-5830	17	68	scienze	scienze	PROPN
bam-5830	17	69	della	della	PROPN
bam-5830	17	70	vita	vita	PROPN
bam-5830	17	71	,	,	PUNCT
bam-5830	17	72	2	2	NUM
bam-5830	18	1	.	.	NOUN
bam-5830	18	2	dipartimento	dipartimento	PROPN
bam-5830	18	3	di	di	PROPN
bam-5830	18	4	scienze	scienze	PROPN
bam-5830	18	5	biomediche	biomediche	PROPN
bam-5830	18	6	,	,	PUNCT
bam-5830	18	7	metaboliche	metaboliche	PROPN
bam-5830	18	8	e	e	PROPN
bam-5830	18	9	neuroscienze	neuroscienze	PROPN
bam-5830	18	10	,	,	PUNCT
bam-5830	18	11	università	università	PROPN
bam-5830	18	12	di	di	PROPN
bam-5830	18	13	modena	modena	PROPN
bam-5830	18	14	e	e	PROPN
bam-5830	18	15	reggio	reggio	PROPN
bam-5830	18	16	emilia	emilia	PROPN
bam-5830	18	17	,	,	PUNCT
bam-5830	18	18	modena	modena	PROPN
bam-5830	18	19	,	,	PUNCT
bam-5830	18	20	italy	italy	PROPN
bam-5830	18	21	;	;	PUNCT
bam-5830	18	22	3	3	X
bam-5830	18	23	.	.	X
bam-5830	18	24	institute	institute	PROPN
bam-5830	18	25	pasteur	pasteur	PROPN
bam-5830	18	26	-	-	PUNCT
bam-5830	18	27	cenci	cenci	PROPN
bam-5830	18	28	bolognetti	bolognetti	NOUN
bam-5830	18	29	,	,	PUNCT
bam-5830	18	30	dahfmo	dahfmo	NOUN
bam-5830	18	31	-	-	PUNCT
bam-5830	18	32	unit	unit	NOUN
bam-5830	18	33	of	of	ADP
bam-5830	18	34	histology	histology	NOUN
bam-5830	18	35	and	and	CCONJ
bam-5830	18	36	medical	medical	ADJ
bam-5830	18	37	embryology	embryology	NOUN
bam-5830	18	38	,	,	PUNCT
bam-5830	18	39	iim	iim	PROPN
bam-5830	18	40	,	,	PUNCT
bam-5830	18	41	sapienza	sapienza	PROPN
bam-5830	18	42	university	university	PROPN
bam-5830	18	43	of	of	ADP
bam-5830	18	44	rome	rome	PROPN
bam-5830	18	45	italy	italy	PROPN
bam-5830	18	46	;	;	PUNCT
bam-5830	18	47	4	4	X
bam-5830	18	48	.	.	X
bam-5830	19	1	department	department	PROPN
bam-5830	19	2	of	of	ADP
bam-5830	19	3	dev	dev	PROPN
bam-5830	19	4	&	&	CCONJ
bam-5830	19	5	stem	stem	NOUN
bam-5830	19	6	cell	cell	NOUN
bam-5830	19	7	biology	biology	NOUN
bam-5830	19	8	,	,	PUNCT
bam-5830	19	9	cnrs	cnrs	NOUN
bam-5830	19	10	ura	ura	NOUN
bam-5830	19	11	2578	2578	NUM
bam-5830	19	12	,	,	PUNCT
bam-5830	19	13	institut	institut	PROPN
bam-5830	19	14	pasteur	pasteur	PROPN
bam-5830	19	15	,	,	PUNCT
bam-5830	19	16	paris	paris	PROPN
bam-5830	19	17	,	,	PUNCT
bam-5830	19	18	france	france	PROPN
bam-5830	19	19	e	e	PROPN
bam-5830	19	20	-	-	NOUN
bam-5830	19	21	mail	mail	NOUN
bam-5830	19	22	:	:	PUNCT
bam-5830	19	23	susanna.molinari@unimore.it	susanna.molinari@unimore.it	NOUN
bam-5830	19	24	muscle	muscle	NOUN
bam-5830	19	25	regeneration	regeneration	NOUN
bam-5830	19	26	is	be	AUX
bam-5830	19	27	a	a	DET
bam-5830	19	28	multistep	multistep	ADJ
bam-5830	19	29	process	process	NOUN
bam-5830	19	30	that	that	PRON
bam-5830	19	31	is	be	AUX
bam-5830	19	32	regulated	regulate	VERB
bam-5830	19	33	by	by	ADP
bam-5830	19	34	a	a	DET
bam-5830	19	35	restricted	restricted	ADJ
bam-5830	19	36	number	number	NOUN
bam-5830	19	37	of	of	ADP
bam-5830	19	38	transcription	transcription	NOUN
bam-5830	19	39	factors	factor	NOUN
bam-5830	19	40	whose	whose	DET
bam-5830	19	41	activity	activity	NOUN
bam-5830	19	42	is	be	AUX
bam-5830	19	43	modulated	modulate	VERB
bam-5830	19	44	at	at	ADP
bam-5830	19	45	multiple	multiple	ADJ
bam-5830	19	46	levels	level	NOUN
bam-5830	19	47	.	.	PUNCT
bam-5830	20	1	however	however	ADV
bam-5830	20	2	,	,	PUNCT
bam-5830	20	3	how	how	SCONJ
bam-5830	20	4	different	different	ADJ
bam-5830	20	5	layers	layer	NOUN
bam-5830	20	6	of	of	ADP
bam-5830	20	7	regulation	regulation	NOUN
bam-5830	20	8	are	be	AUX
bam-5830	20	9	coordinated	coordinate	VERB
bam-5830	20	10	to	to	PART
bam-5830	20	11	promote	promote	VERB
bam-5830	20	12	adult	adult	NOUN
bam-5830	20	13	myogenesis	myogenesis	NOUN
bam-5830	20	14	is	be	AUX
bam-5830	20	15	not	not	PART
bam-5830	20	16	yet	yet	ADV
bam-5830	20	17	understood	understand	VERB
bam-5830	20	18	.	.	PUNCT
bam-5830	21	1	here	here	ADV
bam-5830	21	2	we	we	PRON
bam-5830	21	3	show	show	VERB
bam-5830	21	4	that	that	SCONJ
bam-5830	21	5	the	the	DET
bam-5830	21	6	mef2c	mef2c	PROPN
bam-5830	21	7	transcription	transcription	NOUN
bam-5830	21	8	factor	factor	NOUN
bam-5830	21	9	controls	control	VERB
bam-5830	21	10	multiple	multiple	ADJ
bam-5830	21	11	steps	step	NOUN
bam-5830	21	12	of	of	ADP
bam-5830	21	13	muscle	muscle	NOUN
bam-5830	21	14	regeneration	regeneration	NOUN
bam-5830	21	15	,	,	PUNCT
bam-5830	21	16	including	include	VERB
bam-5830	21	17	myogenic	myogenic	ADJ
bam-5830	21	18	progression	progression	NOUN
bam-5830	21	19	of	of	ADP
bam-5830	21	20	satellite	satellite	NOUN
bam-5830	21	21	cells	cell	NOUN
bam-5830	21	22	and	and	CCONJ
bam-5830	21	23	muscle	muscle	NOUN
bam-5830	21	24	maturation	maturation	NOUN
bam-5830	21	25	of	of	ADP
bam-5830	21	26	newly	newly	ADV
bam-5830	21	27	generated	generate	VERB
bam-5830	21	28	myofibers	myofiber	NOUN
bam-5830	21	29	,	,	PUNCT
bam-5830	21	30	exhibiting	exhibit	VERB
bam-5830	21	31	multiple	multiple	ADJ
bam-5830	21	32	functions	function	NOUN
bam-5830	21	33	that	that	PRON
bam-5830	21	34	depend	depend	VERB
bam-5830	21	35	on	on	ADP
bam-5830	21	36	alternative	alternative	ADJ
bam-5830	21	37	splicing	splicing	NOUN
bam-5830	21	38	and	and	CCONJ
bam-5830	21	39	post	post	ADJ
bam-5830	21	40	-	-	ADJ
bam-5830	21	41	translational	translational	ADJ
bam-5830	21	42	modifications	modification	NOUN
bam-5830	21	43	.	.	PUNCT
bam-5830	22	1	inclusion	inclusion	NOUN
bam-5830	22	2	of	of	ADP
bam-5830	22	3	the	the	DET
bam-5830	22	4	1	1	PROPN
bam-5830	22	5	exon	exon	NOUN
bam-5830	22	6	in	in	ADP
bam-5830	22	7	mef2c	mef2c	NOUN
bam-5830	22	8	transcripts	transcript	NOUN
bam-5830	22	9	is	be	AUX
bam-5830	22	10	upregulated	upregulate	VERB
bam-5830	22	11	in	in	ADP
bam-5830	22	12	proliferating	proliferate	VERB
bam-5830	22	13	mouse	mouse	NOUN
bam-5830	22	14	satellite	satellite	NOUN
bam-5830	22	15	cells	cell	NOUN
bam-5830	22	16	and	and	CCONJ
bam-5830	22	17	in	in	ADP
bam-5830	22	18	the	the	DET
bam-5830	22	19	early	early	ADJ
bam-5830	22	20	phases	phase	NOUN
bam-5830	22	21	of	of	ADP
bam-5830	22	22	muscle	muscle	NOUN
bam-5830	22	23	regeneration	regeneration	NOUN
bam-5830	22	24	.	.	PUNCT
bam-5830	23	1	the	the	DET
bam-5830	23	2	encoded	encode	VERB
bam-5830	23	3	mef2c1	mef2c1	NOUN
bam-5830	23	4	isoform	isoform	NOUN
bam-5830	23	5	stimulates	stimulate	VERB
bam-5830	23	6	expansion	expansion	NOUN
bam-5830	23	7	of	of	ADP
bam-5830	23	8	primary	primary	ADJ
bam-5830	23	9	myoblasts	myoblast	NOUN
bam-5830	23	10	ex	ex	PRON
bam-5830	23	11	vivo	vivo	VERB
bam-5830	23	12	and	and	CCONJ
bam-5830	23	13	in	in	ADP
bam-5830	23	14	vivo	vivo	NOUN
bam-5830	23	15	.	.	PUNCT
bam-5830	24	1	the	the	DET
bam-5830	24	2	proproliferative	proproliferative	ADJ
bam-5830	24	3	activity	activity	NOUN
bam-5830	24	4	of	of	ADP
bam-5830	24	5	mef2c	mef2c	PROPN
bam-5830	24	6	is	be	AUX
bam-5830	24	7	mediated	mediate	VERB
bam-5830	24	8	by	by	ADP
bam-5830	24	9	phosphorylation	phosphorylation	NOUN
bam-5830	24	10	of	of	ADP
bam-5830	24	11	two	two	NUM
bam-5830	24	12	phosphoserines	phosphoserine	NOUN
bam-5830	24	13	located	locate	VERB
bam-5830	24	14	in	in	ADP
bam-5830	24	15	exon	exon	PROPN
bam-5830	24	16	1	1	PROPN
bam-5830	24	17	.	.	PUNCT
bam-5830	24	18	subsequent	subsequent	ADJ
bam-5830	24	19	terminal	terminal	ADJ
bam-5830	24	20	differentiation	differentiation	NOUN
bam-5830	24	21	and	and	CCONJ
bam-5830	24	22	growth	growth	NOUN
bam-5830	24	23	of	of	ADP
bam-5830	24	24	newly	newly	ADV
bam-5830	24	25	formed	form	VERB
bam-5830	24	26	myofibers	myofiber	NOUN
bam-5830	24	27	are	be	AUX
bam-5830	24	28	promoted	promote	VERB
bam-5830	24	29	by	by	ADP
bam-5830	24	30	dephosphorylated	dephosphorylate	VERB
bam-5830	24	31	mef2c1	mef2c1	NOUN
bam-5830	24	32	and	and	CCONJ
bam-5830	24	33	mef2c2	mef2c2	PROPN
bam-5830	24	34	.	.	PUNCT
bam-5830	25	1	our	our	PRON
bam-5830	25	2	results	result	NOUN
bam-5830	25	3	thus	thus	ADV
bam-5830	25	4	reveal	reveal	VERB
bam-5830	25	5	an	an	DET
bam-5830	25	6	important	important	ADJ
bam-5830	25	7	role	role	NOUN
bam-5830	25	8	for	for	ADP
bam-5830	25	9	regulatory	regulatory	ADJ
bam-5830	25	10	interactions	interaction	NOUN
bam-5830	25	11	between	between	ADP
bam-5830	25	12	alternative	alternative	ADJ
bam-5830	25	13	splicing	splicing	NOUN
bam-5830	25	14	and	and	CCONJ
bam-5830	25	15	post	post	VERB
bam-5830	25	16	translational	translational	ADJ
bam-5830	25	17	modifications	modification	NOUN
bam-5830	25	18	of	of	ADP
bam-5830	25	19	a	a	DET
bam-5830	25	20	single	single	ADJ
bam-5830	25	21	transcription	transcription	NOUN
bam-5830	25	22	factor	factor	NOUN
bam-5830	25	23	in	in	ADP
bam-5830	25	24	the	the	DET
bam-5830	25	25	control	control	NOUN
bam-5830	25	26	of	of	ADP
bam-5830	25	27	the	the	DET
bam-5830	25	28	multilayered	multilayered	ADJ
bam-5830	25	29	regulatory	regulatory	ADJ
bam-5830	25	30	programs	program	NOUN
bam-5830	25	31	required	require	VERB
bam-5830	25	32	for	for	ADP
bam-5830	25	33	adult	adult	NOUN
bam-5830	25	34	myogenesis	myogenesis	NOUN
bam-5830	25	35	.	.	PUNCT
bam-5830	26	1	*	*	PUNCT
bam-5830	26	2	*	*	PUNCT
bam-5830	26	3	*	*	PUNCT
bam-5830	26	4	*	*	PUNCT
bam-5830	26	5	*	*	PUNCT
bam-5830	26	6	hdac4	hdac4	NOUN
bam-5830	26	7	is	be	AUX
bam-5830	26	8	necessary	necessary	ADJ
bam-5830	26	9	for	for	ADP
bam-5830	26	10	satellite	satellite	NOUN
bam-5830	26	11	cell	cell	NOUN
bam-5830	26	12	differentiation	differentiation	NOUN
bam-5830	26	13	and	and	CCONJ
bam-5830	26	14	muscle	muscle	NOUN
bam-5830	26	15	regeneration	regeneration	NOUN
bam-5830	26	16	n.	n.	NOUN
bam-5830	26	17	marroncelli	marroncelli	PROPN
bam-5830	26	18	1	1	NUM
bam-5830	26	19	,	,	PUNCT
bam-5830	26	20	c.	c.	PROPN
bam-5830	26	21	noviello	noviello	PROPN
bam-5830	26	22	1	1	NUM
bam-5830	26	23	,	,	PUNCT
bam-5830	26	24	s.	s.	PROPN
bam-5830	26	25	di	di	PROPN
bam-5830	26	26	francescantonio	francescantonio	PROPN
bam-5830	26	27	1	1	NUM
bam-5830	26	28	,	,	PUNCT
bam-5830	26	29	s.	s.	PROPN
bam-5830	26	30	consalvi	consalvi	PROPN
bam-5830	26	31	2	2	NUM
bam-5830	26	32	,	,	PUNCT
bam-5830	26	33	v.	v.	ADP
bam-5830	26	34	saccone	saccone	NOUN
bam-5830	26	35	2	2	NUM
bam-5830	26	36	,	,	PUNCT
bam-5830	27	1	p.	p.	PROPN
bam-5830	27	2	l.	l.	PROPN
bam-5830	27	3	puri	puri	PROPN
bam-5830	27	4	2	2	NUM
bam-5830	27	5	,	,	PUNCT
bam-5830	27	6	e.	e.	PROPN
bam-5830	27	7	n.	n.	PROPN
bam-5830	27	8	olson	olson	PROPN
bam-5830	27	9	3	3	NUM
bam-5830	27	10	,	,	PUNCT
bam-5830	27	11	s.	s.	PROPN
bam-5830	27	12	adamo	adamo	PROPN
bam-5830	27	13	1	1	PROPN
bam-5830	27	14	,	,	PUNCT
bam-5830	27	15	v.	v.	CCONJ
bam-5830	27	16	moresi	moresi	ADJ
bam-5830	27	17	1	1	NUM
bam-5830	27	18	1	1	NUM
bam-5830	27	19	.	.	PUNCT
bam-5830	27	20	dept	dept	PROPN
bam-5830	27	21	.	.	PROPN
bam-5830	27	22	of	of	ADP
bam-5830	27	23	anat	anat	PROPN
bam-5830	27	24	,	,	PUNCT
bam-5830	27	25	histol	histol	NOUN
bam-5830	27	26	,	,	PUNCT
bam-5830	27	27	forens	foren	NOUN
bam-5830	27	28	,	,	PUNCT
bam-5830	27	29	orthop	orthop	NOUN
bam-5830	27	30	sciences	science	NOUN
bam-5830	27	31	,	,	PUNCT
bam-5830	27	32	sapienza	sapienza	PROPN
bam-5830	27	33	university	university	PROPN
bam-5830	27	34	of	of	ADP
bam-5830	27	35	rome	rome	PROPN
bam-5830	27	36	,	,	PUNCT
bam-5830	27	37	italy	italy	PROPN
bam-5830	27	38	;	;	PUNCT
bam-5830	27	39	2	2	X
bam-5830	27	40	.	.	X
bam-5830	27	41	istituto	istituto	PROPN
bam-5830	27	42	di	di	PROPN
bam-5830	27	43	ricovero	ricovero	PROPN
bam-5830	27	44	e	e	PROPN
bam-5830	27	45	cura	cura	PROPN
bam-5830	27	46	a	a	PROPN
bam-5830	27	47	carattere	carattere	PROPN
bam-5830	27	48	scientifico	scientifico	PROPN
bam-5830	27	49	(	(	PUNCT
bam-5830	27	50	i.r.c.c.s	i.r.c.c.	VERB
bam-5830	27	51	.	.	PUNCT
bam-5830	27	52	)	)	PUNCT
bam-5830	28	1	fondazione	fondazione	PROPN
bam-5830	28	2	santa	santa	PROPN
bam-5830	28	3	lucia	lucia	PROPN
bam-5830	28	4	,	,	PUNCT
bam-5830	28	5	rome	rome	PROPN
bam-5830	28	6	,	,	PUNCT
bam-5830	28	7	italy	italy	PROPN
bam-5830	28	8	;	;	PUNCT
bam-5830	28	9	3	3	X
bam-5830	28	10	.	.	X
bam-5830	28	11	dept	dept	PROPN
bam-5830	28	12	.	.	PROPN
bam-5830	28	13	of	of	ADP
bam-5830	28	14	molecular	molecular	ADJ
bam-5830	28	15	biology	biology	NOUN
bam-5830	28	16	,	,	PUNCT
bam-5830	28	17	university	university	PROPN
bam-5830	28	18	of	of	ADP
bam-5830	28	19	texas	texas	PROPN
bam-5830	28	20	southwestern	southwestern	PROPN
bam-5830	28	21	medical	medical	ADJ
bam-5830	28	22	center	center	NOUN
bam-5830	28	23	,	,	PUNCT
bam-5830	28	24	dallas	dallas	PROPN
bam-5830	28	25	,	,	PUNCT
bam-5830	28	26	tx	tx	PROPN
bam-5830	28	27	,	,	PUNCT
bam-5830	28	28	usa	usa	PROPN
bam-5830	28	29	e	e	PROPN
bam-5830	28	30	-	-	NOUN
bam-5830	28	31	mail	mail	NOUN
bam-5830	28	32	:	:	PUNCT
bam-5830	28	33	viviana.moresi@uniroma1.it	viviana.moresi@uniroma1.it	NUM
bam-5830	28	34	skeletal	skeletal	ADJ
bam-5830	28	35	muscle	muscle	NOUN
bam-5830	28	36	exhibits	exhibit	VERB
bam-5830	28	37	a	a	DET
bam-5830	28	38	high	high	ADJ
bam-5830	28	39	capacity	capacity	NOUN
bam-5830	28	40	to	to	PART
bam-5830	28	41	regenerate	regenerate	VERB
bam-5830	28	42	,	,	PUNCT
bam-5830	28	43	mainly	mainly	ADV
bam-5830	28	44	due	due	ADP
bam-5830	28	45	to	to	ADP
bam-5830	28	46	the	the	DET
bam-5830	28	47	ability	ability	NOUN
bam-5830	28	48	of	of	ADP
bam-5830	28	49	satellite	satellite	NOUN
bam-5830	28	50	cells	cell	NOUN
bam-5830	28	51	to	to	PART
bam-5830	28	52	replicate	replicate	VERB
bam-5830	28	53	and	and	CCONJ
bam-5830	28	54	differentiate	differentiate	VERB
bam-5830	28	55	in	in	ADP
bam-5830	28	56	response	response	NOUN
bam-5830	28	57	to	to	ADP
bam-5830	28	58	stimuli	stimulus	NOUN
bam-5830	28	59	.	.	PUNCT
bam-5830	29	1	epigenetic	epigenetic	ADJ
bam-5830	29	2	control	control	NOUN
bam-5830	29	3	is	be	AUX
bam-5830	29	4	effective	effective	ADJ
bam-5830	29	5	at	at	ADP
bam-5830	29	6	multiple	multiple	ADJ
bam-5830	29	7	steps	step	NOUN
bam-5830	29	8	of	of	ADP
bam-5830	29	9	this	this	DET
bam-5830	29	10	process	process	NOUN
bam-5830	29	11	.	.	PUNCT
bam-5830	30	1	the	the	DET
bam-5830	30	2	chromatin	chromatin	NOUN
bam-5830	30	3	remodeling	remodeling	NOUN
bam-5830	30	4	factor	factor	NOUN
bam-5830	30	5	,	,	PUNCT
bam-5830	30	6	hdac4	hdac4	PROPN
bam-5830	30	7	,	,	PUNCT
bam-5830	30	8	is	be	AUX
bam-5830	30	9	up	up	ADV
bam-5830	30	10	-	-	PUNCT
bam-5830	30	11	regulated	regulate	VERB
bam-5830	30	12	in	in	ADP
bam-5830	30	13	skeletal	skeletal	ADJ
bam-5830	30	14	muscle	muscle	NOUN
bam-5830	30	15	upon	upon	SCONJ
bam-5830	30	16	injury	injury	NOUN
bam-5830	30	17	,	,	PUNCT
bam-5830	30	18	suggesting	suggest	VERB
bam-5830	30	19	a	a	DET
bam-5830	30	20	role	role	NOUN
bam-5830	30	21	for	for	ADP
bam-5830	30	22	this	this	DET
bam-5830	30	23	protein	protein	NOUN
bam-5830	30	24	in	in	ADP
bam-5830	30	25	muscle	muscle	NOUN
bam-5830	30	26	regeneration	regeneration	NOUN
bam-5830	30	27	.	.	PUNCT
bam-5830	31	1	with	with	ADP
bam-5830	31	2	the	the	DET
bam-5830	31	3	aim	aim	NOUN
bam-5830	31	4	to	to	PART
bam-5830	31	5	elucidate	elucidate	VERB
bam-5830	31	6	the	the	DET
bam-5830	31	7	role	role	NOUN
bam-5830	31	8	of	of	ADP
bam-5830	31	9	hdac4	hdac4	NOUN
bam-5830	31	10	in	in	ADP
bam-5830	31	11	satellite	satellite	NOUN
bam-5830	31	12	cells	cell	NOUN
bam-5830	31	13	and	and	CCONJ
bam-5830	31	14	skeletal	skeletal	ADJ
bam-5830	31	15	muscle	muscle	NOUN
bam-5830	31	16	regeneration	regeneration	NOUN
bam-5830	31	17	,	,	PUNCT
bam-5830	31	18	we	we	PRON
bam-5830	31	19	generated	generate	VERB
bam-5830	31	20	inducible	inducible	ADJ
bam-5830	31	21	mice	mouse	NOUN
bam-5830	31	22	lacking	lack	VERB
bam-5830	31	23	hdac4	hdac4	NOUN
bam-5830	31	24	in	in	ADP
bam-5830	31	25	pax7	pax7	PROPN
bam-5830	31	26	+	+	CCONJ
bam-5830	31	27	cells	cell	NOUN
bam-5830	31	28	abstracts	abstract	NOUN
bam-5830	31	29	of	of	ADP
bam-5830	31	30	the	the	DET
bam-5830	31	31	xii	xii	PROPN
bam-5830	31	32	iim	iim	NOUN
bam-5830	31	33	myology	myology	NOUN
bam-5830	31	34	meeting	meeting	NOUN
bam-5830	31	35	october	october	PROPN
bam-5830	31	36	1–4	1–4	PROPN
bam-5830	31	37	,	,	PUNCT
bam-5830	31	38	2015	2015	NUM
bam-5830	32	1	eur	eur	PROPN
bam-5830	32	2	j	j	PROPN
bam-5830	32	3	transl	transl	PROPN
bam-5830	32	4	myol	myol	PROPN
bam-5830	32	5	basic	basic	ADJ
bam-5830	32	6	appl	appl	NOUN
bam-5830	32	7	myol	myol	NOUN
bam-5830	32	8	2016	2016	NUM
bam-5830	32	9	;	;	PUNCT
bam-5830	32	10	26	26	NUM
bam-5830	32	11	(	(	PUNCT
bam-5830	32	12	1):2	1):2	NUM
bam-5830	32	13	-	-	SYM
bam-5830	32	14	24	24	NUM
bam-5830	32	15	this	this	DET
bam-5830	32	16	article	article	NOUN
bam-5830	32	17	is	be	AUX
bam-5830	32	18	distributed	distribute	VERB
bam-5830	32	19	under	under	ADP
bam-5830	32	20	the	the	DET
bam-5830	32	21	terms	term	NOUN
bam-5830	32	22	of	of	ADP
bam-5830	32	23	the	the	DET
bam-5830	32	24	creative	creative	ADJ
bam-5830	32	25	commons	common	NOUN
bam-5830	32	26	attribution	attribution	NOUN
bam-5830	32	27	noncommercial	noncommercial	ADJ
bam-5830	32	28	license	license	NOUN
bam-5830	32	29	(	(	PUNCT
bam-5830	32	30	cc	cc	NOUN
bam-5830	32	31	by	by	ADP
bam-5830	32	32	-	-	PUNCT
bam-5830	32	33	nc	nc	PROPN
bam-5830	32	34	4.0	4.0	NUM
bam-5830	32	35	)	)	PUNCT
bam-5830	32	36	which	which	PRON
bam-5830	32	37	permits	permit	VERB
bam-5830	32	38	any	any	DET
bam-5830	32	39	noncommercial	noncommercial	ADJ
bam-5830	32	40	use	use	NOUN
bam-5830	32	41	,	,	PUNCT
bam-5830	32	42	distribution	distribution	NOUN
bam-5830	32	43	,	,	PUNCT
bam-5830	32	44	and	and	CCONJ
bam-5830	32	45	reproduction	reproduction	NOUN
bam-5830	32	46	in	in	ADP
bam-5830	32	47	any	any	DET
bam-5830	32	48	medium	medium	NOUN
bam-5830	32	49	,	,	PUNCT
bam-5830	32	50	provided	provide	VERB
bam-5830	32	51	the	the	DET
bam-5830	32	52	original	original	ADJ
bam-5830	32	53	author(s	author(s	NOUN
bam-5830	32	54	)	)	PUNCT
bam-5830	32	55	and	and	CCONJ
bam-5830	32	56	source	source	NOUN
bam-5830	32	57	are	be	AUX
bam-5830	32	58	credited	credit	VERB
bam-5830	32	59	.	.	PUNCT
bam-5830	33	1	4	4	NUM
bam-5830	33	2	(	(	PUNCT
bam-5830	33	3	hdac4	hdac4	NOUN
bam-5830	33	4	ko	ko	PROPN
bam-5830	33	5	mice	mice	PROPN
bam-5830	33	6	)	)	PUNCT
bam-5830	33	7	.	.	PUNCT
bam-5830	34	1	despite	despite	SCONJ
bam-5830	34	2	having	have	VERB
bam-5830	34	3	similar	similar	ADJ
bam-5830	34	4	amount	amount	NOUN
bam-5830	34	5	of	of	ADP
bam-5830	34	6	satellite	satellite	NOUN
bam-5830	34	7	cells	cell	NOUN
bam-5830	34	8	,	,	PUNCT
bam-5830	34	9	hdac4	hdac4	NOUN
bam-5830	34	10	ko	ko	NOUN
bam-5830	34	11	mice	mouse	NOUN
bam-5830	34	12	show	show	VERB
bam-5830	34	13	impaired	impaired	ADJ
bam-5830	34	14	muscle	muscle	NOUN
bam-5830	34	15	regeneration	regeneration	NOUN
bam-5830	34	16	in	in	ADP
bam-5830	34	17	vivo	vivo	NOUN
bam-5830	34	18	,	,	PUNCT
bam-5830	34	19	and	and	CCONJ
bam-5830	34	20	compromised	compromise	VERB
bam-5830	34	21	satellite	satellite	NOUN
bam-5830	34	22	cell	cell	NOUN
bam-5830	34	23	proliferation	proliferation	NOUN
bam-5830	34	24	and	and	CCONJ
bam-5830	34	25	differentiation	differentiation	NOUN
bam-5830	34	26	in	in	ADP
bam-5830	34	27	vitro	vitro	X
bam-5830	34	28	.	.	PUNCT
bam-5830	35	1	hdac4	hdac4	NOUN
bam-5830	35	2	deletion	deletion	NOUN
bam-5830	35	3	in	in	ADP
bam-5830	35	4	satellite	satellite	NOUN
bam-5830	35	5	cells	cell	NOUN
bam-5830	35	6	is	be	AUX
bam-5830	35	7	sufficient	sufficient	ADJ
bam-5830	35	8	to	to	PART
bam-5830	35	9	block	block	VERB
bam-5830	35	10	their	their	PRON
bam-5830	35	11	differentiation	differentiation	NOUN
bam-5830	35	12	,	,	PUNCT
bam-5830	35	13	not	not	PART
bam-5830	35	14	acting	act	VERB
bam-5830	35	15	via	via	ADP
bam-5830	35	16	soluble	soluble	ADJ
bam-5830	35	17	factors	factor	NOUN
bam-5830	35	18	,	,	PUNCT
bam-5830	35	19	and	and	CCONJ
bam-5830	35	20	possibly	possibly	ADV
bam-5830	35	21	through	through	ADP
bam-5830	35	22	the	the	DET
bam-5830	35	23	inhibition	inhibition	NOUN
bam-5830	35	24	of	of	ADP
bam-5830	35	25	pax7	pax7	ADJ
bam-5830	35	26	expression	expression	NOUN
bam-5830	35	27	.	.	PUNCT
bam-5830	36	1	the	the	DET
bam-5830	36	2	molecular	molecular	ADJ
bam-5830	36	3	mechanisms	mechanism	NOUN
bam-5830	36	4	underling	underle	VERB
bam-5830	36	5	compromised	compromise	VERB
bam-5830	36	6	muscle	muscle	NOUN
bam-5830	36	7	regeneration	regeneration	NOUN
bam-5830	36	8	in	in	ADP
bam-5830	36	9	hdac4	hdac4	NOUN
bam-5830	36	10	ko	ko	NOUN
bam-5830	36	11	mice	mouse	NOUN
bam-5830	36	12	are	be	AUX
bam-5830	36	13	currently	currently	ADV
bam-5830	36	14	under	under	ADP
bam-5830	36	15	investigation	investigation	NOUN
bam-5830	36	16	.	.	PUNCT
bam-5830	37	1	all	all	ADV
bam-5830	37	2	together	together	ADV
bam-5830	37	3	,	,	PUNCT
bam-5830	37	4	these	these	DET
bam-5830	37	5	data	datum	NOUN
bam-5830	37	6	delineate	delineate	VERB
bam-5830	37	7	the	the	DET
bam-5830	37	8	importance	importance	NOUN
bam-5830	37	9	of	of	ADP
bam-5830	37	10	hdac4	hdac4	NOUN
bam-5830	37	11	in	in	ADP
bam-5830	37	12	satellite	satellite	NOUN
bam-5830	37	13	cell	cell	NOUN
bam-5830	37	14	differentiation	differentiation	NOUN
bam-5830	37	15	and	and	CCONJ
bam-5830	37	16	suggest	suggest	VERB
bam-5830	37	17	a	a	DET
bam-5830	37	18	protective	protective	ADJ
bam-5830	37	19	role	role	NOUN
bam-5830	37	20	of	of	ADP
bam-5830	37	21	hdac4	hdac4	NOUN
bam-5830	37	22	in	in	ADP
bam-5830	37	23	response	response	NOUN
bam-5830	37	24	to	to	ADP
bam-5830	37	25	muscle	muscle	NOUN
bam-5830	37	26	damage	damage	NOUN
bam-5830	37	27	.	.	PUNCT
bam-5830	38	1	*	*	PUNCT
bam-5830	38	2	*	*	PUNCT
bam-5830	38	3	*	*	PUNCT
bam-5830	38	4	*	*	PUNCT
bam-5830	38	5	*	*	PUNCT
bam-5830	38	6	the	the	DET
bam-5830	38	7	potential	potential	NOUN
bam-5830	38	8	of	of	ADP
bam-5830	38	9	mass	mass	ADJ
bam-5830	38	10	cytometry	cytometry	NOUN
bam-5830	38	11	to	to	PART
bam-5830	38	12	reveal	reveal	VERB
bam-5830	38	13	the	the	DET
bam-5830	38	14	complex	complex	ADJ
bam-5830	38	15	interplay	interplay	NOUN
bam-5830	38	16	between	between	ADP
bam-5830	38	17	muscle	muscle	NOUN
bam-5830	38	18	resident	resident	ADJ
bam-5830	38	19	mononuclear	mononuclear	ADJ
bam-5830	38	20	cells	cell	NOUN
bam-5830	38	21	during	during	ADP
bam-5830	38	22	regeneration	regeneration	NOUN
bam-5830	38	23	f.	f.	PROPN
bam-5830	38	24	spada	spada	PROPN
bam-5830	38	25	,	,	PUNCT
bam-5830	38	26	c.	c.	NOUN
bam-5830	38	27	fuoco	fuoco	PROPN
bam-5830	38	28	,	,	PUNCT
bam-5830	38	29	s.	s.	PROPN
bam-5830	38	30	pirrò	pirrò	PROPN
bam-5830	38	31	,	,	PUNCT
bam-5830	38	32	a.	a.	NOUN
bam-5830	38	33	reggio	reggio	PROPN
bam-5830	38	34	,	,	PUNCT
bam-5830	38	35	s.	s.	PROPN
bam-5830	38	36	paoluzi	paoluzi	PROPN
bam-5830	38	37	,	,	PUNCT
bam-5830	38	38	c.	c.	PROPN
bam-5830	38	39	gargioli	gargioli	PROPN
bam-5830	38	40	,	,	PUNCT
bam-5830	38	41	l.	l.	PROPN
bam-5830	38	42	castagnoli	castagnoli	PROPN
bam-5830	38	43	,	,	PUNCT
bam-5830	38	44	g.	g.	PROPN
bam-5830	38	45	cesareni	cesareni	PROPN
bam-5830	38	46	department	department	PROPN
bam-5830	38	47	of	of	ADP
bam-5830	38	48	biology	biology	NOUN
bam-5830	38	49	,	,	PUNCT
bam-5830	38	50	rome	rome	PROPN
bam-5830	38	51	university	university	NOUN
bam-5830	38	52	tor	tor	PROPN
bam-5830	38	53	vergata	vergata	PROPN
bam-5830	38	54	,	,	PUNCT
bam-5830	38	55	italy	italy	PROPN
bam-5830	38	56	e	e	PROPN
bam-5830	38	57	-	-	NOUN
bam-5830	38	58	mail	mail	NOUN
bam-5830	38	59	:	:	PUNCT
bam-5830	38	60	cesareni@uniroma2.it	cesareni@uniroma2.it	VERB
bam-5830	38	61	the	the	DET
bam-5830	38	62	adult	adult	NOUN
bam-5830	38	63	skeletal	skeletal	ADJ
bam-5830	38	64	muscle	muscle	NOUN
bam-5830	38	65	has	have	VERB
bam-5830	38	66	the	the	DET
bam-5830	38	67	ability	ability	NOUN
bam-5830	38	68	to	to	PART
bam-5830	38	69	self	self	NOUN
bam-5830	38	70	-	-	PUNCT
bam-5830	38	71	renew	renew	NOUN
bam-5830	38	72	and	and	CCONJ
bam-5830	38	73	repair	repair	VERB
bam-5830	38	74	in	in	ADP
bam-5830	38	75	response	response	NOUN
bam-5830	38	76	to	to	ADP
bam-5830	38	77	increased	increase	VERB
bam-5830	38	78	workload	workload	NOUN
bam-5830	38	79	,	,	PUNCT
bam-5830	38	80	stress	stress	NOUN
bam-5830	38	81	conditions	condition	NOUN
bam-5830	38	82	or	or	CCONJ
bam-5830	38	83	limited	limited	ADJ
bam-5830	38	84	damage	damage	NOUN
bam-5830	38	85	.	.	PUNCT
bam-5830	39	1	these	these	DET
bam-5830	39	2	properties	property	NOUN
bam-5830	39	3	rely	rely	VERB
bam-5830	39	4	on	on	ADP
bam-5830	39	5	an	an	DET
bam-5830	39	6	array	array	NOUN
bam-5830	39	7	of	of	ADP
bam-5830	39	8	different	different	ADJ
bam-5830	39	9	progenitor	progenitor	NOUN
bam-5830	39	10	cell	cell	NOUN
bam-5830	39	11	populations	population	NOUN
bam-5830	39	12	.	.	PUNCT
bam-5830	40	1	while	while	SCONJ
bam-5830	40	2	satellite	satellite	NOUN
bam-5830	40	3	cells	cell	NOUN
bam-5830	40	4	play	play	VERB
bam-5830	40	5	a	a	DET
bam-5830	40	6	central	central	ADJ
bam-5830	40	7	role	role	NOUN
bam-5830	40	8	in	in	ADP
bam-5830	40	9	muscle	muscle	NOUN
bam-5830	40	10	regeneration	regeneration	NOUN
bam-5830	40	11	,	,	PUNCT
bam-5830	40	12	a	a	DET
bam-5830	40	13	variety	variety	NOUN
bam-5830	40	14	of	of	ADP
bam-5830	40	15	other	other	ADJ
bam-5830	40	16	mononuclear	mononuclear	ADJ
bam-5830	40	17	progenitor	progenitor	NOUN
bam-5830	40	18	cells	cell	NOUN
bam-5830	40	19	,	,	PUNCT
bam-5830	40	20	either	either	CCONJ
bam-5830	40	21	resident	resident	NOUN
bam-5830	40	22	in	in	ADP
bam-5830	40	23	the	the	DET
bam-5830	40	24	muscle	muscle	NOUN
bam-5830	40	25	or	or	CCONJ
bam-5830	40	26	recruited	recruit	VERB
bam-5830	40	27	from	from	ADP
bam-5830	40	28	the	the	DET
bam-5830	40	29	blood	blood	NOUN
bam-5830	40	30	stream	stream	NOUN
bam-5830	40	31	,	,	PUNCT
bam-5830	40	32	contribute	contribute	VERB
bam-5830	40	33	to	to	ADP
bam-5830	40	34	the	the	DET
bam-5830	40	35	complex	complex	ADJ
bam-5830	40	36	crosstalk	crosstalk	NOUN
bam-5830	40	37	leading	lead	VERB
bam-5830	40	38	to	to	ADP
bam-5830	40	39	muscle	muscle	NOUN
bam-5830	40	40	repair	repair	NOUN
bam-5830	40	41	.	.	PUNCT
bam-5830	41	1	in	in	ADP
bam-5830	41	2	pathological	pathological	ADJ
bam-5830	41	3	conditions	condition	NOUN
bam-5830	41	4	or	or	CCONJ
bam-5830	41	5	with	with	ADP
bam-5830	41	6	aging	aging	NOUN
bam-5830	41	7	,	,	PUNCT
bam-5830	41	8	the	the	DET
bam-5830	41	9	relative	relative	ADJ
bam-5830	41	10	abundance	abundance	NOUN
bam-5830	41	11	and	and	CCONJ
bam-5830	41	12	the	the	DET
bam-5830	41	13	activation	activation	NOUN
bam-5830	41	14	stage	stage	NOUN
bam-5830	41	15	of	of	ADP
bam-5830	41	16	the	the	DET
bam-5830	41	17	different	different	ADJ
bam-5830	41	18	cell	cell	NOUN
bam-5830	41	19	populations	population	NOUN
bam-5830	41	20	in	in	ADP
bam-5830	41	21	the	the	DET
bam-5830	41	22	myogenic	myogenic	ADJ
bam-5830	41	23	stem	stem	NOUN
bam-5830	41	24	cell	cell	NOUN
bam-5830	41	25	compartment	compartment	NOUN
bam-5830	41	26	vary	vary	VERB
bam-5830	41	27	.	.	PUNCT
bam-5830	42	1	the	the	DET
bam-5830	42	2	ability	ability	NOUN
bam-5830	42	3	to	to	PART
bam-5830	42	4	probe	probe	VERB
bam-5830	42	5	the	the	DET
bam-5830	42	6	heterogeneity	heterogeneity	NOUN
bam-5830	42	7	and	and	CCONJ
bam-5830	42	8	the	the	DET
bam-5830	42	9	dynamic	dynamic	NOUN
bam-5830	42	10	of	of	ADP
bam-5830	42	11	the	the	DET
bam-5830	42	12	muscle	muscle	NOUN
bam-5830	42	13	tissue	tissue	NOUN
bam-5830	42	14	is	be	AUX
bam-5830	42	15	fundamental	fundamental	ADJ
bam-5830	42	16	to	to	PART
bam-5830	42	17	achieve	achieve	VERB
bam-5830	42	18	a	a	DET
bam-5830	42	19	complete	complete	ADJ
bam-5830	42	20	understanding	understanding	NOUN
bam-5830	42	21	of	of	ADP
bam-5830	42	22	muscle	muscle	NOUN
bam-5830	42	23	regeneration	regeneration	NOUN
bam-5830	42	24	.	.	PUNCT
bam-5830	43	1	to	to	ADP
bam-5830	43	2	this	this	DET
bam-5830	43	3	end	end	NOUN
bam-5830	43	4	we	we	PRON
bam-5830	43	5	have	have	AUX
bam-5830	43	6	invested	invest	VERB
bam-5830	43	7	in	in	ADP
bam-5830	43	8	a	a	DET
bam-5830	43	9	novel	novel	ADJ
bam-5830	43	10	approach	approach	NOUN
bam-5830	43	11	exploiting	exploit	VERB
bam-5830	43	12	mass	mass	ADJ
bam-5830	43	13	cytometry	cytometry	NOUN
bam-5830	43	14	technology	technology	NOUN
bam-5830	43	15	(	(	PUNCT
bam-5830	43	16	cytof2	cytof2	PROPN
bam-5830	43	17	platform	platform	PROPN
bam-5830	43	18	)	)	PUNCT
bam-5830	43	19	.	.	PUNCT
bam-5830	44	1	cytof	cytof	NOUN
bam-5830	44	2	technology	technology	NOUN
bam-5830	44	3	enables	enable	VERB
bam-5830	44	4	probing	probe	VERB
bam-5830	44	5	single	single	ADJ
bam-5830	44	6	cell	cell	NOUN
bam-5830	44	7	events	event	NOUN
bam-5830	44	8	,	,	PUNCT
bam-5830	44	9	by	by	ADP
bam-5830	44	10	labelling	label	VERB
bam-5830	44	11	intracellular	intracellular	NOUN
bam-5830	44	12	and	and	CCONJ
bam-5830	44	13	cell	cell	NOUN
bam-5830	44	14	surface	surface	NOUN
bam-5830	44	15	markers	marker	NOUN
bam-5830	44	16	with	with	ADP
bam-5830	44	17	up	up	ADP
bam-5830	44	18	to	to	PART
bam-5830	44	19	40	40	NUM
bam-5830	44	20	antibodies	antibody	NOUN
bam-5830	44	21	tagged	tag	VERB
bam-5830	44	22	with	with	ADP
bam-5830	44	23	stable	stable	ADJ
bam-5830	44	24	heavy	heavy	ADJ
bam-5830	44	25	metal	metal	NOUN
bam-5830	44	26	isotopes	isotope	NOUN
bam-5830	44	27	.	.	PUNCT
bam-5830	45	1	the	the	DET
bam-5830	45	2	sharp	sharp	ADJ
bam-5830	45	3	mass	mass	ADJ
bam-5830	45	4	peaks	peak	NOUN
bam-5830	45	5	obtained	obtain	VERB
bam-5830	45	6	by	by	ADP
bam-5830	45	7	tof	tof	PRON
bam-5830	45	8	inductively	inductively	ADV
bam-5830	45	9	coupled	couple	VERB
bam-5830	45	10	plasma	plasma	NOUN
bam-5830	45	11	mass	mass	PROPN
bam-5830	45	12	spectrometry	spectrometry	NOUN
bam-5830	45	13	eliminates	eliminate	VERB
bam-5830	45	14	the	the	DET
bam-5830	45	15	problems	problem	NOUN
bam-5830	45	16	of	of	ADP
bam-5830	45	17	spectra	spectra	ADJ
bam-5830	45	18	overlap	overlap	NOUN
bam-5830	45	19	typical	typical	ADJ
bam-5830	45	20	of	of	ADP
bam-5830	45	21	fluorescence	fluorescence	NOUN
bam-5830	45	22	based	base	VERB
bam-5830	45	23	flow	flow	NOUN
bam-5830	45	24	cytometry	cytometry	NOUN
bam-5830	45	25	.	.	PUNCT
bam-5830	46	1	i	i	PRON
bam-5830	46	2	will	will	AUX
bam-5830	46	3	describe	describe	VERB
bam-5830	46	4	the	the	DET
bam-5830	46	5	panel	panel	NOUN
bam-5830	46	6	of	of	ADP
bam-5830	46	7	tagged	tag	VERB
bam-5830	46	8	antibodies	antibody	NOUN
bam-5830	46	9	that	that	PRON
bam-5830	46	10	i	i	PRON
bam-5830	46	11	have	have	AUX
bam-5830	46	12	developed	develop	VERB
bam-5830	46	13	to	to	PART
bam-5830	46	14	characterize	characterize	VERB
bam-5830	46	15	the	the	DET
bam-5830	46	16	heterogeneous	heterogeneous	ADJ
bam-5830	46	17	muscle	muscle	NOUN
bam-5830	46	18	mononuclear	mononuclear	ADJ
bam-5830	46	19	cell	cell	NOUN
bam-5830	46	20	populations	population	NOUN
bam-5830	46	21	and	and	CCONJ
bam-5830	46	22	the	the	DET
bam-5830	46	23	advantages	advantage	NOUN
bam-5830	46	24	and	and	CCONJ
bam-5830	46	25	limitations	limitation	NOUN
bam-5830	46	26	of	of	ADP
bam-5830	46	27	mass	mass	ADJ
bam-5830	46	28	cytometry	cytometry	NOUN
bam-5830	46	29	.	.	PUNCT
bam-5830	47	1	in	in	ADP
bam-5830	47	2	addition	addition	NOUN
bam-5830	47	3	i	i	PRON
bam-5830	47	4	will	will	AUX
bam-5830	47	5	present	present	VERB
bam-5830	47	6	preliminary	preliminary	ADJ
bam-5830	47	7	data	datum	NOUN
bam-5830	47	8	on	on	ADP
bam-5830	47	9	the	the	DET
bam-5830	47	10	dynamic	dynamic	NOUN
bam-5830	47	11	of	of	ADP
bam-5830	47	12	cell	cell	NOUN
bam-5830	47	13	populations	population	NOUN
bam-5830	47	14	under	under	ADP
bam-5830	47	15	different	different	ADJ
bam-5830	47	16	conditions	condition	NOUN
bam-5830	47	17	and	and	CCONJ
bam-5830	47	18	stimuli	stimulus	NOUN
bam-5830	47	19	.	.	PUNCT
bam-5830	48	1	*	*	PUNCT
bam-5830	48	2	*	*	PUNCT
bam-5830	48	3	*	*	PUNCT
bam-5830	48	4	*	*	PUNCT
bam-5830	48	5	*	*	PUNCT
bam-5830	48	6	nf	nf	INTJ
bam-5830	48	7	-	-	PUNCT
bam-5830	48	8	y	y	PROPN
bam-5830	48	9	splice	splice	NOUN
bam-5830	48	10	variants	variant	NOUN
bam-5830	48	11	differentially	differentially	ADV
bam-5830	48	12	affect	affect	VERB
bam-5830	48	13	skeletal	skeletal	ADJ
bam-5830	48	14	myogenesis	myogenesis	NOUN
bam-5830	48	15	v.	v.	ADP
bam-5830	48	16	basile	basile	PROPN
bam-5830	48	17	1	1	NUM
bam-5830	48	18	,	,	PUNCT
bam-5830	48	19	f.	f.	PROPN
bam-5830	48	20	baruffaldi	baruffaldi	PROPN
bam-5830	48	21	1	1	NUM
bam-5830	48	22	,	,	PUNCT
bam-5830	48	23	d.	d.	PROPN
bam-5830	48	24	dolfini	dolfini	PROPN
bam-5830	48	25	2	2	NUM
bam-5830	48	26	,	,	PUNCT
bam-5830	48	27	l.	l.	PROPN
bam-5830	48	28	ricci	ricci	PROPN
bam-5830	48	29	1	1	NUM
bam-5830	48	30	,	,	PUNCT
bam-5830	48	31	r.	r.	PROPN
bam-5830	48	32	mantovani	mantovani	PROPN
bam-5830	48	33	2	2	NUM
bam-5830	48	34	,	,	PUNCT
bam-5830	48	35	s.	s.	PROPN
bam-5830	48	36	molinari	molinari	PROPN
bam-5830	48	37	1	1	NUM
bam-5830	48	38	,	,	PUNCT
bam-5830	48	39	c.	c.	PROPN
bam-5830	48	40	imbriano	imbriano	PROPN
bam-5830	48	41	1	1	NUM
bam-5830	48	42	1	1	NUM
bam-5830	48	43	.	.	X
bam-5830	49	1	dipartimento	dipartimento	ADP
bam-5830	49	2	di	di	PROPN
bam-5830	49	3	scienze	scienze	PROPN
bam-5830	49	4	della	della	PROPN
bam-5830	49	5	vita	vita	PROPN
bam-5830	49	6	,	,	PUNCT
bam-5830	49	7	università	università	PROPN
bam-5830	49	8	di	di	PROPN
bam-5830	49	9	modena	modena	PROPN
bam-5830	49	10	e	e	PROPN
bam-5830	49	11	reggio	reggio	PROPN
bam-5830	49	12	emilia	emilia	PROPN
bam-5830	49	13	,	,	PUNCT
bam-5830	49	14	italy	italy	PROPN
bam-5830	49	15	;	;	PUNCT
bam-5830	49	16	2	2	X
bam-5830	49	17	.	.	X
bam-5830	49	18	dipartimento	dipartimento	PROPN
bam-5830	49	19	di	di	X
bam-5830	49	20	scienze	scienze	PROPN
bam-5830	49	21	biomolecolari	biomolecolari	PROPN
bam-5830	49	22	e	e	PROPN
bam-5830	49	23	biotecnologie	biotecnologie	PROPN
bam-5830	49	24	,	,	PUNCT
bam-5830	49	25	università	università	PROPN
bam-5830	49	26	degli	degli	PROPN
bam-5830	49	27	studi	studi	PROPN
bam-5830	49	28	di	di	X
bam-5830	49	29	milano	milano	PROPN
bam-5830	49	30	,	,	PUNCT
bam-5830	49	31	italy	italy	PROPN
bam-5830	49	32	.	.	PUNCT
bam-5830	50	1	e	e	X
bam-5830	50	2	-	-	NOUN
bam-5830	50	3	mail	mail	NOUN
bam-5830	50	4	:	:	PUNCT
bam-5830	50	5	valentina.basile@unimore.it	valentina.basile@unimore.it	NOUN
bam-5830	50	6	the	the	DET
bam-5830	50	7	mechanisms	mechanism	NOUN
bam-5830	50	8	that	that	PRON
bam-5830	50	9	regulate	regulate	VERB
bam-5830	50	10	skeletal	skeletal	ADJ
bam-5830	50	11	muscle	muscle	NOUN
bam-5830	50	12	development	development	NOUN
bam-5830	50	13	involve	involve	VERB
bam-5830	50	14	the	the	DET
bam-5830	50	15	coordinated	coordinated	ADJ
bam-5830	50	16	activity	activity	NOUN
bam-5830	50	17	of	of	ADP
bam-5830	50	18	transcription	transcription	NOUN
bam-5830	50	19	factors	factor	NOUN
bam-5830	50	20	(	(	PUNCT
bam-5830	50	21	tfs	tfs	PROPN
bam-5830	50	22	)	)	PUNCT
bam-5830	50	23	and	and	CCONJ
bam-5830	50	24	a	a	DET
bam-5830	50	25	precise	precise	ADJ
bam-5830	50	26	timing	timing	NOUN
bam-5830	50	27	of	of	ADP
bam-5830	50	28	gene	gene	NOUN
bam-5830	50	29	expression	expression	NOUN
bam-5830	50	30	patterns	pattern	NOUN
bam-5830	50	31	.	.	PUNCT
bam-5830	51	1	nf	nf	X
bam-5830	51	2	-	-	PUNCT
bam-5830	51	3	y	y	PROPN
bam-5830	51	4	is	be	AUX
bam-5830	51	5	a	a	DET
bam-5830	51	6	heterotrimeric	heterotrimeric	NOUN
bam-5830	51	7	tf	tf	X
bam-5830	51	8	with	with	ADP
bam-5830	51	9	a	a	DET
bam-5830	51	10	pioneer	pioneer	NOUN
bam-5830	51	11	role	role	NOUN
bam-5830	51	12	in	in	ADP
bam-5830	51	13	the	the	DET
bam-5830	51	14	transcriptional	transcriptional	ADJ
bam-5830	51	15	and	and	CCONJ
bam-5830	51	16	epigenetic	epigenetic	ADJ
bam-5830	51	17	regulation	regulation	NOUN
bam-5830	51	18	of	of	ADP
bam-5830	51	19	promoters	promoter	NOUN
bam-5830	51	20	containing	contain	VERB
bam-5830	51	21	the	the	DET
bam-5830	51	22	ccaat	ccaat	NOUN
bam-5830	51	23	-	-	PUNCT
bam-5830	51	24	box	box	NOUN
bam-5830	51	25	.	.	PUNCT
bam-5830	52	1	nf	nf	PROPN
bam-5830	52	2	-	-	PUNCT
bam-5830	52	3	y	y	PROPN
bam-5830	52	4	activates	activate	VERB
bam-5830	52	5	the	the	DET
bam-5830	52	6	expression	expression	NOUN
bam-5830	52	7	of	of	ADP
bam-5830	52	8	various	various	ADJ
bam-5830	52	9	genes	gene	NOUN
bam-5830	52	10	related	relate	VERB
bam-5830	52	11	to	to	ADP
bam-5830	52	12	the	the	DET
bam-5830	52	13	cell	cell	NOUN
bam-5830	52	14	cycle	cycle	NOUN
bam-5830	52	15	,	,	PUNCT
bam-5830	52	16	particularly	particularly	ADV
bam-5830	52	17	genes	gene	NOUN
bam-5830	52	18	of	of	ADP
bam-5830	52	19	the	the	DET
bam-5830	52	20	g2	g2	PROPN
bam-5830	52	21	/	/	SYM
bam-5830	52	22	m	m	PROPN
bam-5830	52	23	phase	phase	NOUN
bam-5830	52	24	.	.	PUNCT
bam-5830	53	1	nf	nf	PROPN
bam-5830	53	2	-	-	PUNCT
bam-5830	53	3	ya	ya	PROPN
bam-5830	53	4	,	,	PUNCT
bam-5830	53	5	the	the	DET
bam-5830	53	6	regulatory	regulatory	ADJ
bam-5830	53	7	dna	dna	NOUN
bam-5830	53	8	-	-	PUNCT
bam-5830	53	9	binding	bind	VERB
bam-5830	53	10	subunit	subunit	NOUN
bam-5830	53	11	of	of	ADP
bam-5830	53	12	the	the	DET
bam-5830	53	13	complex	complex	NOUN
bam-5830	53	14	,	,	PUNCT
bam-5830	53	15	is	be	AUX
bam-5830	53	16	expressed	express	VERB
bam-5830	53	17	in	in	ADP
bam-5830	53	18	proliferating	proliferate	VERB
bam-5830	53	19	myoblasts	myoblast	NOUN
bam-5830	53	20	and	and	CCONJ
bam-5830	53	21	downregulated	downregulate	VERB
bam-5830	53	22	during	during	ADP
bam-5830	53	23	terminal	terminal	ADJ
bam-5830	53	24	differentiation	differentiation	NOUN
bam-5830	53	25	.	.	PUNCT
bam-5830	54	1	the	the	DET
bam-5830	54	2	nf	nf	ADJ
bam-5830	54	3	-	-	PUNCT
bam-5830	54	4	ya	ya	NOUN
bam-5830	54	5	gene	gene	NOUN
bam-5830	54	6	encodes	encode	NOUN
bam-5830	54	7	for	for	ADP
bam-5830	54	8	two	two	NUM
bam-5830	54	9	alternatively	alternatively	ADV
bam-5830	54	10	spliced	splice	VERB
bam-5830	54	11	isoforms	isoform	NOUN
bam-5830	54	12	,	,	PUNCT
bam-5830	54	13	namely	namely	ADV
bam-5830	54	14	nfyas	nfyas	NOUN
bam-5830	54	15	and	and	CCONJ
bam-5830	54	16	nf	nf	ADJ
bam-5830	54	17	-	-	PUNCT
bam-5830	54	18	yal	yal	NOUN
bam-5830	54	19	,	,	PUNCT
bam-5830	54	20	which	which	PRON
bam-5830	54	21	are	be	AUX
bam-5830	54	22	not	not	PART
bam-5830	54	23	functionally	functionally	ADV
bam-5830	54	24	identical	identical	ADJ
bam-5830	54	25	.	.	PUNCT
bam-5830	55	1	using	use	VERB
bam-5830	55	2	mouse	mouse	NOUN
bam-5830	55	3	c2c12	c2c12	PROPN
bam-5830	55	4	cells	cell	NOUN
bam-5830	55	5	,	,	PUNCT
bam-5830	55	6	we	we	PRON
bam-5830	55	7	provide	provide	VERB
bam-5830	55	8	evidence	evidence	NOUN
bam-5830	55	9	of	of	ADP
bam-5830	55	10	a	a	DET
bam-5830	55	11	different	different	ADJ
bam-5830	55	12	role	role	NOUN
bam-5830	55	13	for	for	ADP
bam-5830	55	14	nf	nf	ADJ
bam-5830	55	15	-	-	PUNCT
bam-5830	55	16	ya	ya	NOUN
bam-5830	55	17	variants	variant	NOUN
bam-5830	55	18	in	in	ADP
bam-5830	55	19	the	the	DET
bam-5830	55	20	myogenic	myogenic	ADJ
bam-5830	55	21	program	program	NOUN
bam-5830	55	22	.	.	PUNCT
bam-5830	56	1	while	while	SCONJ
bam-5830	56	2	nfyas	nfyas	NOUN
bam-5830	56	3	enhances	enhance	VERB
bam-5830	56	4	myoblasts	myoblast	NOUN
bam-5830	56	5	proliferation	proliferation	NOUN
bam-5830	56	6	,	,	PUNCT
bam-5830	56	7	nf	nf	ADJ
bam-5830	56	8	-	-	PUNCT
bam-5830	56	9	yal	yal	NOUN
bam-5830	56	10	boosts	boost	VERB
bam-5830	56	11	their	their	PRON
bam-5830	56	12	differentiation	differentiation	NOUN
bam-5830	56	13	by	by	ADP
bam-5830	56	14	up	up	ADV
bam-5830	56	15	-	-	PUNCT
bam-5830	56	16	regulating	regulate	VERB
bam-5830	56	17	the	the	DET
bam-5830	56	18	transcription	transcription	NOUN
bam-5830	56	19	of	of	ADP
bam-5830	56	20	novel	novel	ADJ
bam-5830	56	21	target	target	NOUN
bam-5830	56	22	genes	gene	NOUN
bam-5830	56	23	,	,	PUNCT
bam-5830	56	24	among	among	ADP
bam-5830	56	25	which	which	PRON
bam-5830	56	26	mef2d	mef2d	ADP
bam-5830	56	27	,	,	PUNCT
bam-5830	56	28	sixs	sixs	NOUN
bam-5830	56	29	and	and	CCONJ
bam-5830	56	30	cdkn1c	cdkn1c	NOUN
bam-5830	56	31	,	,	PUNCT
bam-5830	56	32	which	which	PRON
bam-5830	56	33	are	be	AUX
bam-5830	56	34	known	know	VERB
bam-5830	56	35	to	to	PART
bam-5830	56	36	be	be	AUX
bam-5830	56	37	involved	involve	VERB
bam-5830	56	38	in	in	ADP
bam-5830	56	39	the	the	DET
bam-5830	56	40	differentiation	differentiation	NOUN
bam-5830	56	41	program	program	NOUN
bam-5830	56	42	.	.	PUNCT
bam-5830	57	1	we	we	PRON
bam-5830	57	2	further	far	ADV
bam-5830	57	3	demonstrate	demonstrate	VERB
bam-5830	57	4	that	that	SCONJ
bam-5830	57	5	nf	nf	NOUN
bam-5830	57	6	-	-	PUNCT
bam-5830	57	7	ya	ya	PROPN
bam-5830	57	8	is	be	AUX
bam-5830	57	9	expressed	express	VERB
bam-5830	57	10	in	in	ADP
bam-5830	57	11	resident	resident	ADJ
bam-5830	57	12	stem	stem	NOUN
bam-5830	57	13	cells	cell	NOUN
bam-5830	57	14	(	(	PUNCT
bam-5830	57	15	scs	scs	ADJ
bam-5830	57	16	)	)	PUNCT
bam-5830	57	17	and	and	CCONJ
bam-5830	57	18	the	the	DET
bam-5830	57	19	two	two	NUM
bam-5830	57	20	isoforms	isoform	NOUN
bam-5830	57	21	are	be	AUX
bam-5830	57	22	transcribed	transcribe	VERB
bam-5830	57	23	at	at	ADP
bam-5830	57	24	different	different	ADJ
bam-5830	57	25	levels	level	NOUN
bam-5830	57	26	during	during	ADP
bam-5830	57	27	scs	scs	NOUN
bam-5830	57	28	activation	activation	NOUN
bam-5830	57	29	and	and	CCONJ
bam-5830	57	30	differentiation	differentiation	NOUN
bam-5830	57	31	.	.	PUNCT
bam-5830	58	1	the	the	DET
bam-5830	58	2	inhibition	inhibition	NOUN
bam-5830	58	3	of	of	ADP
bam-5830	58	4	nf	nf	ADJ
bam-5830	58	5	-	-	PUNCT
bam-5830	58	6	y	y	NOUN
bam-5830	58	7	activity	activity	NOUN
bam-5830	58	8	impairs	impair	VERB
bam-5830	58	9	both	both	DET
bam-5830	58	10	proliferation	proliferation	NOUN
bam-5830	58	11	and	and	CCONJ
bam-5830	58	12	differentiation	differentiation	NOUN
bam-5830	58	13	of	of	ADP
bam-5830	58	14	scs	scs	PROPN
bam-5830	58	15	and	and	CCONJ
bam-5830	58	16	the	the	DET
bam-5830	58	17	overexpression	overexpression	NOUN
bam-5830	58	18	of	of	ADP
bam-5830	58	19	the	the	DET
bam-5830	58	20	two	two	NUM
bam-5830	58	21	nfya	nfya	ADJ
bam-5830	58	22	isoforms	isoform	NOUN
bam-5830	58	23	differentially	differentially	ADV
bam-5830	58	24	affects	affect	VERB
bam-5830	58	25	their	their	PRON
bam-5830	58	26	fate	fate	NOUN
bam-5830	58	27	.	.	PUNCT
bam-5830	59	1	*	*	PUNCT
bam-5830	60	1	*	*	PUNCT
bam-5830	60	2	*	*	PUNCT
bam-5830	60	3	*	*	PUNCT
bam-5830	60	4	*	*	NOUN
bam-5830	60	5	role	role	NOUN
bam-5830	60	6	of	of	ADP
bam-5830	60	7	the	the	DET
bam-5830	60	8	oxidative	oxidative	ADJ
bam-5830	60	9	stress	stress	NOUN
bam-5830	60	10	in	in	ADP
bam-5830	60	11	the	the	DET
bam-5830	60	12	alteration	alteration	NOUN
bam-5830	60	13	of	of	ADP
bam-5830	60	14	muscle	muscle	NOUN
bam-5830	60	15	homeostasis	homeostasis	NOUN
bam-5830	60	16	age	age	NOUN
bam-5830	60	17	-	-	PUNCT
bam-5830	60	18	related	relate	VERB
bam-5830	60	19	r.	r.	PROPN
bam-5830	60	20	mancinelli	mancinelli	PROPN
bam-5830	60	21	,	,	PUNCT
bam-5830	60	22	s.	s.	PROPN
bam-5830	60	23	guarnieri	guarnieri	PROPN
bam-5830	60	24	,	,	PUNCT
bam-5830	60	25	e.s	e.s	PROPN
bam-5830	60	26	.	.	PROPN
bam-5830	60	27	di	di	PROPN
bam-5830	60	28	filippo	filippo	PROPN
bam-5830	60	29	,	,	PUNCT
bam-5830	60	30	t.	t.	PROPN
bam-5830	60	31	pietrangelo	pietrangelo	PROPN
bam-5830	60	32	,	,	PUNCT
bam-5830	60	33	s.	s.	PROPN
bam-5830	60	34	fulle	fulle	PROPN
bam-5830	60	35	department	department	NOUN
bam-5830	60	36	neuroscience	neuroscience	NOUN
bam-5830	60	37	,	,	PUNCT
bam-5830	60	38	imaging	imaging	NOUN
bam-5830	60	39	and	and	CCONJ
bam-5830	60	40	clinical	clinical	ADJ
bam-5830	60	41	sciences	science	NOUN
bam-5830	60	42	,	,	PUNCT
bam-5830	60	43	“	"	PUNCT
bam-5830	60	44	g.	g.	PROPN
bam-5830	60	45	d	d	PROPN
bam-5830	60	46	annunzio	annunzio	PROPN
bam-5830	60	47	”	"	PUNCT
bam-5830	60	48	university	university	NOUN
bam-5830	60	49	,	,	PUNCT
bam-5830	60	50	chieti	chieti	PROPN
bam-5830	60	51	-	-	PUNCT
bam-5830	60	52	pescara	pescara	PROPN
bam-5830	60	53	,	,	PUNCT
bam-5830	60	54	italy	italy	PROPN
bam-5830	60	55	e	e	PROPN
bam-5830	60	56	-	-	NOUN
bam-5830	60	57	mail	mail	NOUN
bam-5830	60	58	:	:	PUNCT
bam-5830	60	59	r.mancinelli@unich.it	r.mancinelli@unich.it	NUM
bam-5830	60	60	sarcopenia	sarcopenia	NOUN
bam-5830	60	61	is	be	AUX
bam-5830	60	62	the	the	DET
bam-5830	60	63	age	age	NOUN
bam-5830	60	64	-	-	PUNCT
bam-5830	60	65	related	relate	VERB
bam-5830	60	66	loss	loss	NOUN
bam-5830	60	67	of	of	ADP
bam-5830	60	68	muscle	muscle	NOUN
bam-5830	60	69	leading	lead	VERB
bam-5830	60	70	to	to	ADP
bam-5830	60	71	loss	loss	NOUN
bam-5830	60	72	of	of	ADP
bam-5830	60	73	muscle	muscle	NOUN
bam-5830	60	74	power	power	NOUN
bam-5830	60	75	,	,	PUNCT
bam-5830	60	76	which	which	PRON
bam-5830	60	77	in	in	ADP
bam-5830	60	78	the	the	DET
bam-5830	60	79	end	end	NOUN
bam-5830	60	80	results	result	NOUN
bam-5830	60	81	in	in	ADP
bam-5830	60	82	frailty	frailty	NOUN
bam-5830	60	83	and	and	CCONJ
bam-5830	60	84	disability	disability	NOUN
bam-5830	60	85	.	.	PUNCT
bam-5830	61	1	at	at	ADP
bam-5830	61	2	molecular	molecular	ADJ
bam-5830	61	3	level	level	NOUN
bam-5830	61	4	,	,	PUNCT
bam-5830	61	5	sarcopenia	sarcopenia	NOUN
bam-5830	61	6	is	be	AUX
bam-5830	61	7	characterized	characterize	VERB
bam-5830	61	8	by	by	ADP
bam-5830	61	9	insufficient	insufficient	ADJ
bam-5830	61	10	antioxidant	antioxidant	ADJ
bam-5830	61	11	defense	defense	NOUN
bam-5830	61	12	mechanism	mechanism	NOUN
bam-5830	61	13	,	,	PUNCT
bam-5830	61	14	increased	increase	VERB
bam-5830	61	15	oxidative	oxidative	ADJ
bam-5830	61	16	stress	stress	NOUN
bam-5830	61	17	and	and	CCONJ
bam-5830	61	18	altered	alter	VERB
bam-5830	61	19	function	function	NOUN
bam-5830	61	20	of	of	ADP
bam-5830	61	21	respiratory	respiratory	ADJ
bam-5830	61	22	chain	chain	NOUN
bam-5830	61	23	.	.	PUNCT
bam-5830	62	1	it	it	PRON
bam-5830	62	2	has	have	AUX
bam-5830	62	3	been	be	AUX
bam-5830	62	4	hypothesized	hypothesize	VERB
bam-5830	62	5	that	that	SCONJ
bam-5830	62	6	the	the	DET
bam-5830	62	7	accumulation	accumulation	NOUN
bam-5830	62	8	of	of	ADP
bam-5830	62	9	oxidative	oxidative	ADJ
bam-5830	62	10	stress	stress	NOUN
bam-5830	62	11	is	be	AUX
bam-5830	62	12	also	also	ADV
bam-5830	62	13	related	relate	VERB
bam-5830	62	14	to	to	ADP
bam-5830	62	15	an	an	DET
bam-5830	62	16	impaired	impaired	ADJ
bam-5830	62	17	regeneration	regeneration	NOUN
bam-5830	62	18	cooperating	cooperate	VERB
bam-5830	62	19	to	to	ADP
bam-5830	62	20	the	the	DET
bam-5830	62	21	atrophic	atrophic	ADJ
bam-5830	62	22	state	state	NOUN
bam-5830	62	23	that	that	PRON
bam-5830	62	24	characterizes	characterize	VERB
bam-5830	62	25	muscle	muscle	NOUN
bam-5830	62	26	ageing	ageing	NOUN
bam-5830	62	27	.	.	PUNCT
bam-5830	63	1	to	to	ADP
bam-5830	63	2	the	the	DET
bam-5830	63	3	purpose	purpose	NOUN
bam-5830	63	4	,	,	PUNCT
bam-5830	63	5	we	we	PRON
bam-5830	63	6	investigated	investigate	VERB
bam-5830	63	7	the	the	DET
bam-5830	63	8	myogenic	myogenic	ADJ
bam-5830	63	9	process	process	NOUN
bam-5830	63	10	in	in	ADP
bam-5830	63	11	satellite	satellite	NOUN
bam-5830	63	12	cells	cell	NOUN
bam-5830	63	13	,	,	PUNCT
bam-5830	63	14	the	the	DET
bam-5830	63	15	skeletal	skeletal	ADJ
bam-5830	63	16	muscle	muscle	NOUN
bam-5830	63	17	stem	stem	NOUN
bam-5830	63	18	cells	cell	NOUN
bam-5830	63	19	,	,	PUNCT
bam-5830	63	20	as	as	SCONJ
bam-5830	63	21	myoblasts	myoblast	NOUN
bam-5830	63	22	and	and	CCONJ
bam-5830	63	23	myotubes	myotube	NOUN
bam-5830	63	24	collected	collect	VERB
bam-5830	63	25	by	by	ADP
bam-5830	63	26	human	human	ADJ
bam-5830	63	27	vastus	vastus	NOUN
bam-5830	63	28	lateralis	lateralis	VERB
bam-5830	63	29	skeletal	skeletal	ADJ
bam-5830	63	30	muscle	muscle	NOUN
bam-5830	63	31	of	of	ADP
bam-5830	63	32	young	young	ADJ
bam-5830	63	33	and	and	CCONJ
bam-5830	63	34	old	old	ADJ
bam-5830	63	35	subjects	subject	NOUN
bam-5830	63	36	through	through	ADP
bam-5830	63	37	needle	needle	NOUN
bam-5830	63	38	-	-	PUNCT
bam-5830	63	39	biopsies	biopsy	NOUN
bam-5830	63	40	.	.	PUNCT
bam-5830	64	1	to	to	PART
bam-5830	64	2	measure	measure	VERB
bam-5830	64	3	both	both	DET
bam-5830	64	4	the	the	DET
bam-5830	64	5	o2and	o2and	NOUN
bam-5830	64	6	ros	ros	PROPN
bam-5830	64	7	level	level	NOUN
bam-5830	64	8	we	we	PRON
bam-5830	64	9	used	use	VERB
bam-5830	64	10	nbt	nbt	NOUN
bam-5830	64	11	and	and	CCONJ
bam-5830	64	12	h2dcf	h2dcf	PROPN
bam-5830	64	13	-	-	PUNCT
bam-5830	64	14	da	da	NOUN
bam-5830	64	15	assays	assay	NOUN
bam-5830	64	16	revealing	reveal	VERB
bam-5830	64	17	higher	high	ADJ
bam-5830	64	18	concentration	concentration	NOUN
bam-5830	64	19	in	in	ADP
bam-5830	64	20	elderly	elderly	ADJ
bam-5830	64	21	myoblasts	myoblast	NOUN
bam-5830	64	22	compared	compare	VERB
bam-5830	64	23	to	to	ADP
bam-5830	64	24	young	young	ADJ
bam-5830	64	25	ones	one	NOUN
bam-5830	64	26	.	.	PUNCT
bam-5830	65	1	to	to	PART
bam-5830	65	2	evaluate	evaluate	VERB
bam-5830	65	3	if	if	SCONJ
bam-5830	65	4	mitochondria	mitochondria	PROPN
bam-5830	65	5	are	be	AUX
bam-5830	65	6	damaged	damage	VERB
bam-5830	65	7	by	by	ADP
bam-5830	65	8	ros	ros	PROPN
bam-5830	65	9	we	we	PRON
bam-5830	65	10	measured	measure	VERB
bam-5830	65	11	mitochondrial	mitochondrial	ADJ
bam-5830	65	12	transmembrane	transmembrane	NOUN
bam-5830	65	13	potential	potential	NOUN
bam-5830	65	14	after	after	ADP
bam-5830	65	15	an	an	DET
bam-5830	65	16	oxidant	oxidant	ADJ
bam-5830	65	17	insult	insult	NOUN
bam-5830	65	18	as	as	ADP
bam-5830	65	19	h2o2	h2o2	NOUN
bam-5830	65	20	.	.	NOUN
bam-5830	65	21	we	we	PRON
bam-5830	65	22	found	find	VERB
bam-5830	65	23	that	that	SCONJ
bam-5830	65	24	in	in	ADP
bam-5830	65	25	elderly	elderly	ADJ
bam-5830	65	26	myoblasts	myoblast	NOUN
bam-5830	65	27	mitochondrial	mitochondrial	ADJ
bam-5830	65	28	transmembrane	transmembrane	NOUN
bam-5830	65	29	potential	potential	NOUN
bam-5830	65	30	decreases	decrease	VERB
bam-5830	65	31	much	much	ADV
bam-5830	65	32	more	more	ADJ
bam-5830	65	33	than	than	ADP
bam-5830	65	34	in	in	ADP
bam-5830	65	35	young	young	ADJ
bam-5830	65	36	ones	one	NOUN
bam-5830	65	37	probably	probably	ADV
bam-5830	65	38	due	due	ADJ
bam-5830	65	39	to	to	ADP
bam-5830	65	40	their	their	PRON
bam-5830	65	41	lower	low	ADJ
bam-5830	65	42	endogenous	endogenous	ADJ
bam-5830	65	43	antioxidant	antioxidant	ADJ
bam-5830	65	44	abilities	ability	NOUN
bam-5830	65	45	.	.	PUNCT
bam-5830	66	1	specifically	specifically	ADV
bam-5830	66	2	,	,	PUNCT
bam-5830	66	3	mitosox	mitosox	ADJ
bam-5830	66	4	™	™	ADJ
bam-5830	66	5	red	red	ADJ
bam-5830	66	6	reagent	reagent	NOUN
bam-5830	66	7	for	for	ADP
bam-5830	66	8	direct	direct	ADJ
bam-5830	66	9	measurements	measurement	NOUN
bam-5830	66	10	of	of	ADP
bam-5830	66	11	o2	o2	PROPN
bam-5830	66	12	in	in	ADP
bam-5830	66	13	mitochondria	mitochondria	NOUN
bam-5830	66	14	revealed	reveal	VERB
bam-5830	66	15	that	that	SCONJ
bam-5830	66	16	in	in	ADP
bam-5830	66	17	elderly	elderly	ADJ
bam-5830	66	18	myoblasts	myoblast	NOUN
bam-5830	66	19	o2production	o2production	NOUN
bam-5830	66	20	is	be	AUX
bam-5830	66	21	increased	increase	VERB
bam-5830	66	22	respect	respect	NOUN
bam-5830	66	23	to	to	ADP
bam-5830	66	24	young	young	ADJ
bam-5830	66	25	ones	one	NOUN
bam-5830	66	26	and	and	CCONJ
bam-5830	66	27	the	the	DET
bam-5830	66	28	result	result	NOUN
bam-5830	66	29	is	be	AUX
bam-5830	66	30	worsened	worsen	VERB
bam-5830	66	31	in	in	ADP
bam-5830	66	32	myotubes	myotube	NOUN
bam-5830	66	33	.	.	PUNCT
bam-5830	67	1	furthermore	furthermore	ADV
bam-5830	67	2	,	,	PUNCT
bam-5830	67	3	the	the	DET
bam-5830	67	4	upregulation	upregulation	NOUN
bam-5830	67	5	of	of	ADP
bam-5830	67	6	the	the	DET
bam-5830	67	7	atrophic	atrophic	ADJ
bam-5830	67	8	and	and	CCONJ
bam-5830	67	9	ubiquitinproteasome	ubiquitinproteasome	VERB
bam-5830	67	10	pathways	pathway	NOUN
bam-5830	67	11	together	together	ADV
bam-5830	67	12	with	with	ADP
bam-5830	67	13	a	a	DET
bam-5830	67	14	dysregulation	dysregulation	NOUN
bam-5830	67	15	of	of	ADP
bam-5830	67	16	the	the	DET
bam-5830	67	17	proliferative	proliferative	ADJ
bam-5830	67	18	one	one	NOUN
bam-5830	67	19	revealed	reveal	VERB
bam-5830	67	20	an	an	DET
bam-5830	67	21	alteration	alteration	NOUN
bam-5830	67	22	at	at	ADP
bam-5830	67	23	gene	gene	NOUN
bam-5830	67	24	expression	expression	NOUN
bam-5830	67	25	level	level	NOUN
bam-5830	67	26	in	in	ADP
bam-5830	67	27	elderly	elderly	ADJ
bam-5830	67	28	myoblasts	myoblast	NOUN
bam-5830	67	29	vs	vs	ADP
bam-5830	67	30	young	young	ADJ
bam-5830	67	31	ones	one	NOUN
bam-5830	67	32	.	.	PUNCT
bam-5830	68	1	overall	overall	ADV
bam-5830	68	2	our	our	PRON
bam-5830	68	3	data	datum	NOUN
bam-5830	68	4	confirm	confirm	VERB
bam-5830	68	5	that	that	PRON
bam-5830	68	6	oxidative	oxidative	ADJ
bam-5830	68	7	stress	stress	NOUN
bam-5830	68	8	impairs	impair	VERB
bam-5830	68	9	muscle	muscle	NOUN
bam-5830	68	10	regeneration	regeneration	NOUN
bam-5830	68	11	in	in	ADP
bam-5830	68	12	elderly	elderly	ADJ
bam-5830	68	13	subjects	subject	NOUN
bam-5830	68	14	.	.	PUNCT
bam-5830	69	1	*	*	PUNCT
bam-5830	69	2	*	*	PUNCT
bam-5830	69	3	*	*	PUNCT
bam-5830	69	4	*	*	PUNCT
bam-5830	69	5	*	*	VERB
bam-5830	69	6	abstracts	abstract	NOUN
bam-5830	69	7	of	of	ADP
bam-5830	69	8	the	the	DET
bam-5830	69	9	xii	xii	PROPN
bam-5830	69	10	iim	iim	NOUN
bam-5830	69	11	myology	myology	NOUN
bam-5830	69	12	meeting	meeting	NOUN
bam-5830	69	13	october	october	PROPN
bam-5830	69	14	1–4	1–4	PROPN
bam-5830	69	15	,	,	PUNCT
bam-5830	69	16	2015	2015	NUM
bam-5830	69	17	eur	eur	PROPN
bam-5830	69	18	j	j	PROPN
bam-5830	69	19	transl	transl	PROPN
bam-5830	69	20	myol	myol	PROPN
bam-5830	69	21	basic	basic	ADJ
bam-5830	69	22	appl	appl	NOUN
bam-5830	69	23	myol	myol	NOUN
bam-5830	69	24	2016	2016	NUM
bam-5830	69	25	;	;	PUNCT
bam-5830	69	26	26	26	NUM
bam-5830	69	27	(	(	PUNCT
bam-5830	69	28	1):2	1):2	NUM
bam-5830	69	29	-	-	SYM
bam-5830	69	30	24	24	NUM
bam-5830	69	31	this	this	DET
bam-5830	69	32	article	article	NOUN
bam-5830	69	33	is	be	AUX
bam-5830	69	34	distributed	distribute	VERB
bam-5830	69	35	under	under	ADP
bam-5830	69	36	the	the	DET
bam-5830	69	37	terms	term	NOUN
bam-5830	69	38	of	of	ADP
bam-5830	69	39	the	the	DET
bam-5830	69	40	creative	creative	ADJ
bam-5830	69	41	commons	common	NOUN
bam-5830	69	42	attribution	attribution	NOUN
bam-5830	69	43	noncommercial	noncommercial	ADJ
bam-5830	69	44	license	license	NOUN
bam-5830	69	45	(	(	PUNCT
bam-5830	69	46	cc	cc	NOUN
bam-5830	69	47	by	by	ADP
bam-5830	69	48	-	-	PUNCT
bam-5830	69	49	nc	nc	PROPN
bam-5830	69	50	4.0	4.0	NUM
bam-5830	69	51	)	)	PUNCT
bam-5830	69	52	which	which	PRON
bam-5830	69	53	permits	permit	VERB
bam-5830	69	54	any	any	DET
bam-5830	69	55	noncommercial	noncommercial	ADJ
bam-5830	69	56	use	use	NOUN
bam-5830	69	57	,	,	PUNCT
bam-5830	69	58	distribution	distribution	NOUN
bam-5830	69	59	,	,	PUNCT
bam-5830	69	60	and	and	CCONJ
bam-5830	69	61	reproduction	reproduction	NOUN
bam-5830	69	62	in	in	ADP
bam-5830	69	63	any	any	DET
bam-5830	69	64	medium	medium	NOUN
bam-5830	69	65	,	,	PUNCT
bam-5830	69	66	provided	provide	VERB
bam-5830	69	67	the	the	DET
bam-5830	69	68	original	original	ADJ
bam-5830	69	69	author(s	author(s	NOUN
bam-5830	69	70	)	)	PUNCT
bam-5830	69	71	and	and	CCONJ
bam-5830	69	72	source	source	NOUN
bam-5830	69	73	are	be	AUX
bam-5830	69	74	credited	credit	VERB
bam-5830	69	75	.	.	PUNCT
bam-5830	70	1	5	5	NUM
bam-5830	70	2	single­cell	single­cell	NOUN
bam-5830	70	3	based	base	VERB
bam-5830	70	4	analysis	analysis	NOUN
bam-5830	70	5	of	of	ADP
bam-5830	70	6	functional	functional	ADJ
bam-5830	70	7	populations	population	NOUN
bam-5830	70	8	in	in	ADP
bam-5830	70	9	aged	aged	ADJ
bam-5830	70	10	and	and	CCONJ
bam-5830	70	11	dystrophic	dystrophic	ADJ
bam-5830	70	12	muscle	muscle	NOUN
bam-5830	70	13	l.	l.	PROPN
bam-5830	70	14	giordani	giordani	PROPN
bam-5830	70	15	1,2	1,2	NUM
bam-5830	70	16	,	,	PUNCT
bam-5830	70	17	f.	f.	PROPN
bam-5830	70	18	le	le	PROPN
bam-5830	71	1	grand	grand	PROPN
bam-5830	71	2	1,2	1,2	NUM
bam-5830	71	3	1	1	NUM
bam-5830	71	4	.	.	PUNCT
bam-5830	71	5	centre	centre	PROPN
bam-5830	71	6	de	de	X
bam-5830	71	7	recherche	recherche	X
bam-5830	71	8	en	en	X
bam-5830	71	9	myologie	myologie	NOUN
bam-5830	71	10	,	,	PUNCT
bam-5830	71	11	105	105	NUM
bam-5830	71	12	,	,	PUNCT
bam-5830	71	13	bld	bld	PROPN
bam-5830	71	14	de	de	PROPN
bam-5830	71	15	l	l	PROPN
bam-5830	71	16	hôpital	hôpital	PROPN
bam-5830	71	17	g.h	g.h	PROPN
bam-5830	71	18	.	.	PROPN
bam-5830	71	19	pitié	pitié	PROPN
bam-5830	71	20	-	-	PUNCT
bam-5830	71	21	salpétrière	salpétrière	NOUN
bam-5830	71	22	,	,	PUNCT
bam-5830	71	23	paris	paris	PROPN
bam-5830	71	24	,	,	PUNCT
bam-5830	71	25	france	france	PROPN
bam-5830	71	26	;	;	PUNCT
bam-5830	71	27	2	2	X
bam-5830	71	28	.	.	X
bam-5830	71	29	institut	institut	PROPN
bam-5830	71	30	national	national	PROPN
bam-5830	71	31	de	de	X
bam-5830	71	32	la	la	X
bam-5830	71	33	santé	santé	X
bam-5830	71	34	et	et	PROPN
bam-5830	71	35	de	de	X
bam-5830	71	36	la	la	X
bam-5830	71	37	recherche	recherche	X
bam-5830	71	38	médicale	médicale	X
bam-5830	71	39	inserm	inserm	PROPN
bam-5830	71	40	u1016	u1016	PROPN
bam-5830	71	41	,	,	PUNCT
bam-5830	71	42	paris	paris	PROPN
bam-5830	71	43	,	,	PUNCT
bam-5830	71	44	france	france	PROPN
bam-5830	71	45	e	e	PROPN
bam-5830	71	46	-	-	NOUN
bam-5830	71	47	mail	mail	NOUN
bam-5830	71	48	:	:	PUNCT
bam-5830	71	49	lorenzo.giordani@inserm.fr	lorenzo.giordani@inserm.fr	ADJ
bam-5830	71	50	skeletal	skeletal	ADJ
bam-5830	71	51	muscle	muscle	NOUN
bam-5830	71	52	is	be	AUX
bam-5830	71	53	a	a	DET
bam-5830	71	54	complex	complex	ADJ
bam-5830	71	55	structure	structure	NOUN
bam-5830	71	56	endowed	endow	VERB
bam-5830	71	57	with	with	ADP
bam-5830	71	58	extreme	extreme	ADJ
bam-5830	71	59	regenerative	regenerative	ADJ
bam-5830	71	60	capability	capability	NOUN
bam-5830	71	61	;	;	PUNCT
bam-5830	71	62	this	this	DET
bam-5830	71	63	ability	ability	NOUN
bam-5830	71	64	relies	rely	VERB
bam-5830	71	65	on	on	ADP
bam-5830	71	66	the	the	DET
bam-5830	71	67	orchestrated	orchestrated	ADJ
bam-5830	71	68	interplay	interplay	NOUN
bam-5830	71	69	between	between	ADP
bam-5830	71	70	different	different	ADJ
bam-5830	71	71	muscle	muscle	NOUN
bam-5830	71	72	populations	population	NOUN
bam-5830	71	73	that	that	PRON
bam-5830	71	74	reside	reside	VERB
bam-5830	71	75	within	within	ADP
bam-5830	71	76	the	the	DET
bam-5830	71	77	tissue	tissue	NOUN
bam-5830	71	78	.	.	PUNCT
bam-5830	72	1	functional	functional	ADJ
bam-5830	72	2	changes	change	NOUN
bam-5830	72	3	occurring	occur	VERB
bam-5830	72	4	at	at	ADP
bam-5830	72	5	the	the	DET
bam-5830	72	6	microenvironmental	microenvironmental	ADJ
bam-5830	72	7	level	level	NOUN
bam-5830	72	8	during	during	ADP
bam-5830	72	9	aging	age	VERB
bam-5830	72	10	or	or	CCONJ
bam-5830	72	11	pathological	pathological	ADJ
bam-5830	72	12	conditions	condition	NOUN
bam-5830	72	13	however	however	ADV
bam-5830	72	14	interfere	interfere	VERB
bam-5830	72	15	with	with	ADP
bam-5830	72	16	this	this	DET
bam-5830	72	17	ability	ability	NOUN
bam-5830	72	18	leading	lead	VERB
bam-5830	72	19	to	to	ADP
bam-5830	72	20	fibrosis	fibrosis	NOUN
bam-5830	72	21	and	and	CCONJ
bam-5830	72	22	fat	fat	ADJ
bam-5830	72	23	infiltration	infiltration	NOUN
bam-5830	72	24	.	.	PUNCT
bam-5830	73	1	despite	despite	SCONJ
bam-5830	73	2	a	a	DET
bam-5830	73	3	large	large	ADJ
bam-5830	73	4	body	body	NOUN
bam-5830	73	5	of	of	ADP
bam-5830	73	6	work	work	NOUN
bam-5830	73	7	still	still	ADV
bam-5830	73	8	we	we	PRON
bam-5830	73	9	are	be	AUX
bam-5830	73	10	far	far	ADV
bam-5830	73	11	from	from	ADP
bam-5830	73	12	completely	completely	ADV
bam-5830	73	13	understanding	understand	VERB
bam-5830	73	14	these	these	DET
bam-5830	73	15	changes	change	NOUN
bam-5830	73	16	;	;	PUNCT
bam-5830	73	17	even	even	ADV
bam-5830	73	18	when	when	SCONJ
bam-5830	73	19	genetic	genetic	ADJ
bam-5830	73	20	cause	cause	NOUN
bam-5830	73	21	is	be	AUX
bam-5830	73	22	known	know	VERB
bam-5830	73	23	(	(	PUNCT
bam-5830	73	24	e.g.	e.g.	ADV
bam-5830	73	25	duchenne	duchenne	VERB
bam-5830	73	26	muscular	muscular	ADJ
bam-5830	73	27	dystrophy	dystrophy	NOUN
bam-5830	73	28	)	)	PUNCT
bam-5830	73	29	we	we	PRON
bam-5830	73	30	are	be	AUX
bam-5830	73	31	still	still	ADV
bam-5830	73	32	unable	unable	ADJ
bam-5830	73	33	to	to	PART
bam-5830	73	34	pin	pin	VERB
bam-5830	73	35	-	-	PUNCT
bam-5830	73	36	point	point	VERB
bam-5830	73	37	the	the	DET
bam-5830	73	38	steps	step	NOUN
bam-5830	73	39	that	that	PRON
bam-5830	73	40	lead	lead	VERB
bam-5830	73	41	from	from	ADP
bam-5830	73	42	the	the	DET
bam-5830	73	43	molecular	molecular	ADJ
bam-5830	73	44	cause	cause	NOUN
bam-5830	73	45	to	to	ADP
bam-5830	73	46	the	the	DET
bam-5830	73	47	outcome	outcome	NOUN
bam-5830	73	48	of	of	ADP
bam-5830	73	49	the	the	DET
bam-5830	73	50	disease	disease	NOUN
bam-5830	73	51	.	.	PUNCT
bam-5830	74	1	the	the	DET
bam-5830	74	2	main	main	ADJ
bam-5830	74	3	reason	reason	NOUN
bam-5830	74	4	for	for	ADP
bam-5830	74	5	this	this	DET
bam-5830	74	6	bottleneck	bottleneck	NOUN
bam-5830	74	7	is	be	AUX
bam-5830	74	8	that	that	SCONJ
bam-5830	74	9	our	our	PRON
bam-5830	74	10	knowledge	knowledge	NOUN
bam-5830	74	11	has	have	AUX
bam-5830	74	12	been	be	AUX
bam-5830	74	13	limited	limit	VERB
bam-5830	74	14	so	so	ADV
bam-5830	74	15	far	far	ADV
bam-5830	74	16	by	by	ADP
bam-5830	74	17	the	the	DET
bam-5830	74	18	lack	lack	NOUN
bam-5830	74	19	of	of	ADP
bam-5830	74	20	technical	technical	ADJ
bam-5830	74	21	tools	tool	NOUN
bam-5830	74	22	to	to	PART
bam-5830	74	23	dissect	dissect	VERB
bam-5830	74	24	the	the	DET
bam-5830	74	25	heterogeneity	heterogeneity	NOUN
bam-5830	74	26	of	of	ADP
bam-5830	74	27	these	these	DET
bam-5830	74	28	populations	population	NOUN
bam-5830	74	29	.	.	PUNCT
bam-5830	75	1	the	the	DET
bam-5830	75	2	use	use	NOUN
bam-5830	75	3	of	of	ADP
bam-5830	75	4	bulk	bulk	ADJ
bam-5830	75	5	-	-	PUNCT
bam-5830	75	6	scale	scale	NOUN
bam-5830	75	7	methods	method	NOUN
bam-5830	75	8	able	able	ADJ
bam-5830	75	9	only	only	ADV
bam-5830	75	10	to	to	PART
bam-5830	75	11	provide	provide	VERB
bam-5830	75	12	averaged	average	VERB
bam-5830	75	13	information	information	NOUN
bam-5830	75	14	has	have	AUX
bam-5830	75	15	frustrated	frustrate	VERB
bam-5830	75	16	our	our	PRON
bam-5830	75	17	effort	effort	NOUN
bam-5830	75	18	to	to	PART
bam-5830	75	19	characterize	characterize	VERB
bam-5830	75	20	those	those	DET
bam-5830	75	21	pathological	pathological	ADJ
bam-5830	75	22	changes	change	NOUN
bam-5830	75	23	leaving	leave	VERB
bam-5830	75	24	those	those	DET
bam-5830	75	25	dysfunctional	dysfunctional	ADJ
bam-5830	75	26	,	,	PUNCT
bam-5830	75	27	disease	disease	NOUN
bam-5830	75	28	-	-	PUNCT
bam-5830	75	29	specific	specific	ADJ
bam-5830	75	30	subpopulation	subpopulation	NOUN
bam-5830	75	31	to	to	PART
bam-5830	75	32	remain	remain	VERB
bam-5830	75	33	hidden	hidden	ADJ
bam-5830	75	34	within	within	ADP
bam-5830	75	35	the	the	DET
bam-5830	75	36	bulk	bulk	NOUN
bam-5830	75	37	.	.	PUNCT
bam-5830	76	1	here	here	ADV
bam-5830	76	2	we	we	PRON
bam-5830	76	3	present	present	VERB
bam-5830	76	4	a	a	DET
bam-5830	76	5	novel	novel	ADJ
bam-5830	76	6	approach	approach	NOUN
bam-5830	76	7	based	base	VERB
bam-5830	76	8	on	on	ADP
bam-5830	76	9	single	single	ADJ
bam-5830	76	10	cell	cell	NOUN
bam-5830	76	11	mass	mass	NOUN
bam-5830	76	12	spectrometry	spectrometry	NOUN
bam-5830	76	13	to	to	PART
bam-5830	76	14	study	study	VERB
bam-5830	76	15	the	the	DET
bam-5830	76	16	populations	population	NOUN
bam-5830	76	17	that	that	PRON
bam-5830	76	18	reside	reside	VERB
bam-5830	76	19	in	in	ADP
bam-5830	76	20	the	the	DET
bam-5830	76	21	muscle	muscle	NOUN
bam-5830	76	22	.	.	PUNCT
bam-5830	77	1	using	use	VERB
bam-5830	77	2	cytof	cytof	NOUN
bam-5830	77	3	technology	technology	NOUN
bam-5830	77	4	we	we	PRON
bam-5830	77	5	would	would	AUX
bam-5830	77	6	profile	profile	VERB
bam-5830	77	7	at	at	ADP
bam-5830	77	8	single	single	ADJ
bam-5830	77	9	cell	cell	NOUN
bam-5830	77	10	resolution	resolution	NOUN
bam-5830	77	11	the	the	DET
bam-5830	77	12	muscle	muscle	NOUN
bam-5830	77	13	resident	resident	NOUN
bam-5830	77	14	populations	population	NOUN
bam-5830	77	15	during	during	ADP
bam-5830	77	16	aging	age	VERB
bam-5830	77	17	and	and	CCONJ
bam-5830	77	18	in	in	ADP
bam-5830	77	19	diseased	diseased	ADJ
bam-5830	77	20	state	state	NOUN
bam-5830	77	21	.	.	PUNCT
bam-5830	78	1	this	this	PRON
bam-5830	78	2	would	would	AUX
bam-5830	78	3	allow	allow	VERB
bam-5830	78	4	us	we	PRON
bam-5830	78	5	to	to	PART
bam-5830	78	6	identify	identify	VERB
bam-5830	78	7	dysfunctional	dysfunctional	ADJ
bam-5830	78	8	subsets	subset	NOUN
bam-5830	78	9	involved	involve	VERB
bam-5830	78	10	in	in	ADP
bam-5830	78	11	the	the	DET
bam-5830	78	12	regeneration	regeneration	NOUN
bam-5830	78	13	defect	defect	NOUN
bam-5830	78	14	.	.	PUNCT
bam-5830	79	1	this	this	DET
bam-5830	79	2	study	study	NOUN
bam-5830	79	3	would	would	AUX
bam-5830	79	4	not	not	PART
bam-5830	79	5	only	only	ADV
bam-5830	79	6	shed	shed	VERB
bam-5830	79	7	light	light	NOUN
bam-5830	79	8	on	on	ADP
bam-5830	79	9	the	the	DET
bam-5830	79	10	mechanisms	mechanism	NOUN
bam-5830	79	11	underpinning	underpin	VERB
bam-5830	79	12	muscle	muscle	NOUN
bam-5830	79	13	regeneration	regeneration	NOUN
bam-5830	79	14	but	but	CCONJ
bam-5830	79	15	would	would	AUX
bam-5830	79	16	provide	provide	VERB
bam-5830	79	17	a	a	DET
bam-5830	79	18	solid	solid	ADJ
bam-5830	79	19	ground	ground	NOUN
bam-5830	79	20	for	for	ADP
bam-5830	79	21	the	the	DET
bam-5830	79	22	future	future	ADJ
bam-5830	79	23	identification	identification	NOUN
bam-5830	79	24	of	of	ADP
bam-5830	79	25	diagnostic	diagnostic	ADJ
bam-5830	79	26	biomarkers	biomarker	NOUN
bam-5830	79	27	through	through	ADP
bam-5830	79	28	the	the	DET
bam-5830	79	29	study	study	NOUN
bam-5830	79	30	of	of	ADP
bam-5830	79	31	disease	disease	NOUN
bam-5830	79	32	specific	specific	ADJ
bam-5830	79	33	subpopulations	subpopulation	NOUN
bam-5830	79	34	.	.	PUNCT
bam-5830	80	1	*	*	PUNCT
bam-5830	80	2	*	*	PUNCT
bam-5830	80	3	*	*	PUNCT
bam-5830	80	4	*	*	PUNCT
bam-5830	80	5	*	*	PUNCT
bam-5830	80	6	exosome	exosome	NUM
bam-5830	80	7	-	-	PUNCT
bam-5830	80	8	bore	bore	NOUN
bam-5830	80	9	micrornas	microrna	NOUN
bam-5830	80	10	in	in	ADP
bam-5830	80	11	muscle	muscle	NOUN
bam-5830	80	12	hypertrophic	hypertrophic	ADJ
bam-5830	80	13	and	and	CCONJ
bam-5830	80	14	dystrophic	dystrophic	ADJ
bam-5830	80	15	conditions	condition	NOUN
bam-5830	80	16	g.	g.	PROPN
bam-5830	80	17	giacomazzi	giacomazzi	PROPN
bam-5830	80	18	,	,	PUNCT
bam-5830	80	19	m.	m.	PROPN
bam-5830	80	20	quattrocelli	quattrocelli	PROPN
bam-5830	80	21	,	,	PUNCT
bam-5830	80	22	m.	m.	NOUN
bam-5830	80	23	sampaolesi	sampaolesi	PROPN
bam-5830	80	24	translational	translational	ADJ
bam-5830	80	25	cardiomyology	cardiomyology	NOUN
bam-5830	80	26	lab	lab	NOUN
bam-5830	80	27	,	,	PUNCT
bam-5830	80	28	stem	stem	NOUN
bam-5830	80	29	cell	cell	NOUN
bam-5830	80	30	and	and	CCONJ
bam-5830	80	31	embryo	embryo	NOUN
bam-5830	80	32	biology	biology	NOUN
bam-5830	80	33	,	,	PUNCT
bam-5830	80	34	dept	dept	NOUN
bam-5830	80	35	development	development	NOUN
bam-5830	80	36	&	&	CCONJ
bam-5830	80	37	regeneration	regeneration	PROPN
bam-5830	80	38	,	,	PUNCT
bam-5830	80	39	ku	ku	PROPN
bam-5830	80	40	leuven	leuven	PROPN
bam-5830	80	41	,	,	PUNCT
bam-5830	80	42	leuven	leuven	PROPN
bam-5830	80	43	,	,	PUNCT
bam-5830	80	44	belgium	belgium	NOUN
bam-5830	80	45	e	e	NOUN
bam-5830	80	46	-	-	NOUN
bam-5830	80	47	mail	mail	NOUN
bam-5830	80	48	:	:	PUNCT
bam-5830	80	49	giorgia.giacomazzi@kuleuven.be	giorgia.giacomazzi@kuleuven.be	NOUN
bam-5830	80	50	hypertrophy	hypertrophy	NOUN
bam-5830	80	51	and	and	CCONJ
bam-5830	80	52	dystrophy	dystrophy	NOUN
bam-5830	80	53	are	be	AUX
bam-5830	80	54	distinct	distinct	ADJ
bam-5830	80	55	,	,	PUNCT
bam-5830	80	56	yet	yet	ADV
bam-5830	80	57	linked	link	VERB
bam-5830	80	58	processes	process	NOUN
bam-5830	80	59	that	that	PRON
bam-5830	80	60	remodel	remodel	VERB
bam-5830	80	61	both	both	CCONJ
bam-5830	80	62	skeletal	skeletal	ADJ
bam-5830	80	63	and	and	CCONJ
bam-5830	80	64	cardiac	cardiac	ADJ
bam-5830	80	65	muscles	muscle	NOUN
bam-5830	80	66	in	in	ADP
bam-5830	80	67	physiological	physiological	ADJ
bam-5830	80	68	or	or	CCONJ
bam-5830	80	69	pathological	pathological	ADJ
bam-5830	80	70	settings	setting	NOUN
bam-5830	80	71	.	.	PUNCT
bam-5830	81	1	not	not	PART
bam-5830	81	2	only	only	ADV
bam-5830	81	3	is	be	AUX
bam-5830	81	4	hypertrophy	hypertrophy	NOUN
bam-5830	81	5	important	important	ADJ
bam-5830	81	6	during	during	ADP
bam-5830	81	7	development	development	NOUN
bam-5830	81	8	,	,	PUNCT
bam-5830	81	9	but	but	CCONJ
bam-5830	81	10	it	it	PRON
bam-5830	81	11	also	also	ADV
bam-5830	81	12	plays	play	VERB
bam-5830	81	13	major	major	ADJ
bam-5830	81	14	role	role	NOUN
bam-5830	81	15	upon	upon	SCONJ
bam-5830	81	16	acute	acute	ADJ
bam-5830	81	17	or	or	CCONJ
bam-5830	81	18	chronic	chronic	ADJ
bam-5830	81	19	damage	damage	NOUN
bam-5830	81	20	.	.	PUNCT
bam-5830	82	1	muscular	muscular	ADJ
bam-5830	82	2	dystrophies	dystrophy	NOUN
bam-5830	82	3	(	(	PUNCT
bam-5830	82	4	mds	mds	NOUN
bam-5830	82	5	)	)	PUNCT
bam-5830	82	6	cause	cause	VERB
bam-5830	82	7	progressive	progressive	ADJ
bam-5830	82	8	degeneration	degeneration	NOUN
bam-5830	82	9	and	and	CCONJ
bam-5830	82	10	loss	loss	NOUN
bam-5830	82	11	of	of	ADP
bam-5830	82	12	functionality	functionality	NOUN
bam-5830	82	13	in	in	ADP
bam-5830	82	14	both	both	CCONJ
bam-5830	82	15	striated	striated	ADJ
bam-5830	82	16	muscle	muscle	NOUN
bam-5830	82	17	types	type	NOUN
bam-5830	82	18	.	.	PUNCT
bam-5830	83	1	in	in	ADP
bam-5830	83	2	md	md	PROPN
bam-5830	83	3	patients	patient	NOUN
bam-5830	83	4	and	and	CCONJ
bam-5830	83	5	animal	animal	NOUN
bam-5830	83	6	models	model	NOUN
bam-5830	83	7	,	,	PUNCT
bam-5830	83	8	an	an	DET
bam-5830	83	9	initial	initial	ADJ
bam-5830	83	10	hypertrophic	hypertrophic	ADJ
bam-5830	83	11	response	response	NOUN
bam-5830	83	12	occurs	occur	VERB
bam-5830	83	13	,	,	PUNCT
bam-5830	83	14	with	with	ADP
bam-5830	83	15	contrasting	contrast	VERB
bam-5830	83	16	effects	effect	NOUN
bam-5830	83	17	on	on	ADP
bam-5830	83	18	skeletal	skeletal	ADJ
bam-5830	83	19	and	and	CCONJ
bam-5830	83	20	cardiac	cardiac	ADJ
bam-5830	83	21	muscle	muscle	NOUN
bam-5830	83	22	.	.	PUNCT
bam-5830	84	1	recently	recently	ADV
bam-5830	84	2	it	it	PRON
bam-5830	84	3	has	have	AUX
bam-5830	84	4	been	be	AUX
bam-5830	84	5	established	establish	VERB
bam-5830	84	6	that	that	SCONJ
bam-5830	84	7	muscle	muscle	NOUN
bam-5830	84	8	fibers	fiber	NOUN
bam-5830	84	9	secrete	secrete	NOUN
bam-5830	84	10	exosomes	exosome	NOUN
bam-5830	84	11	,	,	PUNCT
bam-5830	84	12	whose	whose	DET
bam-5830	84	13	cargo	cargo	NOUN
bam-5830	84	14	acts	act	VERB
bam-5830	84	15	as	as	ADP
bam-5830	84	16	endocrine	endocrine	NOUN
bam-5830	84	17	signals	signal	NOUN
bam-5830	84	18	during	during	ADP
bam-5830	84	19	myogenesis	myogenesis	NOUN
bam-5830	84	20	.	.	PUNCT
bam-5830	85	1	we	we	PRON
bam-5830	85	2	aim	aim	VERB
bam-5830	85	3	at	at	ADP
bam-5830	85	4	deciphering	decipher	VERB
bam-5830	85	5	the	the	DET
bam-5830	85	6	exosomal	exosomal	ADJ
bam-5830	85	7	information	information	NOUN
bam-5830	85	8	guiding	guide	VERB
bam-5830	85	9	hypertrophy	hypertrophy	NOUN
bam-5830	85	10	/	/	SYM
bam-5830	85	11	dystrophy	dystrophy	NOUN
bam-5830	85	12	in	in	ADP
bam-5830	85	13	both	both	DET
bam-5830	85	14	muscle	muscle	NOUN
bam-5830	85	15	in	in	ADP
bam-5830	85	16	order	order	NOUN
bam-5830	85	17	to	to	PART
bam-5830	85	18	establish	establish	VERB
bam-5830	85	19	a	a	DET
bam-5830	85	20	new	new	ADJ
bam-5830	85	21	strategy	strategy	NOUN
bam-5830	85	22	based	base	VERB
bam-5830	85	23	on	on	ADP
bam-5830	85	24	mirna	mirna	PROPN
bam-5830	85	25	modulation	modulation	NOUN
bam-5830	85	26	for	for	ADP
bam-5830	85	27	novel	novel	ADJ
bam-5830	85	28	myogenic	myogenic	ADJ
bam-5830	85	29	regeneration	regeneration	NOUN
bam-5830	85	30	.	.	PUNCT
bam-5830	86	1	we	we	PRON
bam-5830	86	2	performed	perform	VERB
bam-5830	86	3	ex	ex	PRON
bam-5830	86	4	vivo	vivo	NOUN
bam-5830	86	5	exosome	exosome	NOUN
bam-5830	86	6	analysis	analysis	NOUN
bam-5830	86	7	comparing	compare	VERB
bam-5830	86	8	age	age	NOUN
bam-5830	86	9	-	-	PUNCT
bam-5830	86	10	matched	match	VERB
bam-5830	86	11	wt	wt	NOUN
bam-5830	86	12	,	,	PUNCT
bam-5830	86	13	sgcb	sgcb	NOUN
bam-5830	86	14	-	-	PUNCT
bam-5830	86	15	null	null	ADJ
bam-5830	86	16	(	(	PUNCT
bam-5830	86	17	dystrophic	dystrophic	ADJ
bam-5830	86	18	)	)	PUNCT
bam-5830	86	19	,	,	PUNCT
bam-5830	86	20	and	and	CCONJ
bam-5830	86	21	magic	magic	NOUN
bam-5830	86	22	-	-	PUNCT
bam-5830	86	23	f1+/+	f1+/+	PROPN
bam-5830	86	24	(	(	PUNCT
bam-5830	86	25	hypertrophic	hypertrophic	ADJ
bam-5830	86	26	)	)	PUNCT
bam-5830	86	27	mice	mouse	NOUN
bam-5830	86	28	.	.	PUNCT
bam-5830	87	1	we	we	PRON
bam-5830	87	2	detected	detect	VERB
bam-5830	87	3	several	several	ADJ
bam-5830	87	4	differentially	differentially	ADV
bam-5830	87	5	regulated	regulate	VERB
bam-5830	87	6	mirnas	mirna	NOUN
bam-5830	87	7	,	,	PUNCT
bam-5830	87	8	virtually	virtually	ADV
bam-5830	87	9	relevant	relevant	ADJ
bam-5830	87	10	for	for	ADP
bam-5830	87	11	striated	striated	ADJ
bam-5830	87	12	muscle	muscle	NOUN
bam-5830	87	13	remodeling	remodeling	NOUN
bam-5830	87	14	and	and	CCONJ
bam-5830	87	15	de-/regeneration	de-/regeneration	NOUN
bam-5830	87	16	.	.	PUNCT
bam-5830	88	1	we	we	PRON
bam-5830	88	2	have	have	VERB
bam-5830	88	3	preliminary	preliminary	ADJ
bam-5830	88	4	results	result	NOUN
bam-5830	88	5	on	on	ADP
bam-5830	88	6	the	the	DET
bam-5830	88	7	effects	effect	NOUN
bam-5830	88	8	of	of	ADP
bam-5830	88	9	ex	ex	PRON
bam-5830	88	10	vivo	vivo	ADJ
bam-5830	88	11	exosomes	exosome	NOUN
bam-5830	88	12	on	on	ADP
bam-5830	88	13	cell	cell	NOUN
bam-5830	88	14	types	type	NOUN
bam-5830	88	15	relevant	relevant	ADJ
bam-5830	88	16	for	for	ADP
bam-5830	88	17	skeletal	skeletal	ADJ
bam-5830	88	18	and	and	CCONJ
bam-5830	88	19	cardiac	cardiac	ADJ
bam-5830	88	20	muscle	muscle	NOUN
bam-5830	88	21	analysis	analysis	NOUN
bam-5830	88	22	.	.	PUNCT
bam-5830	89	1	moreover	moreover	ADV
bam-5830	89	2	we	we	PRON
bam-5830	89	3	are	be	AUX
bam-5830	89	4	currently	currently	ADV
bam-5830	89	5	investigating	investigate	VERB
bam-5830	89	6	the	the	DET
bam-5830	89	7	uptake	uptake	ADJ
bam-5830	89	8	routes	route	NOUN
bam-5830	89	9	of	of	ADP
bam-5830	89	10	exosomes	exosome	NOUN
bam-5830	89	11	in	in	ADP
bam-5830	89	12	both	both	DET
bam-5830	89	13	muscle	muscle	NOUN
bam-5830	89	14	types	type	NOUN
bam-5830	89	15	.	.	PUNCT
bam-5830	90	1	in	in	ADP
bam-5830	90	2	the	the	DET
bam-5830	90	3	future	future	NOUN
bam-5830	90	4	we	we	PRON
bam-5830	90	5	will	will	AUX
bam-5830	90	6	rely	rely	VERB
bam-5830	90	7	on	on	ADP
bam-5830	90	8	mirna	mirna	NOUN
bam-5830	90	9	-	-	PUNCT
bam-5830	90	10	sequencing	sequencing	NOUN
bam-5830	90	11	of	of	ADP
bam-5830	90	12	ex	ex	PRON
bam-5830	90	13	vivo	vivo	ADJ
bam-5830	90	14	exosomes	exosome	NOUN
bam-5830	90	15	,	,	PUNCT
bam-5830	90	16	to	to	PART
bam-5830	90	17	identify	identify	VERB
bam-5830	90	18	key	key	ADJ
bam-5830	90	19	mrna	mrna	PROPN
bam-5830	90	20	/	/	SYM
bam-5830	90	21	mirna	mirna	PROPN
bam-5830	90	22	distinctive	distinctive	ADJ
bam-5830	90	23	signatures	signature	NOUN
bam-5830	90	24	by	by	ADP
bam-5830	90	25	means	mean	NOUN
bam-5830	90	26	of	of	ADP
bam-5830	90	27	an	an	DET
bam-5830	90	28	high	high	ADJ
bam-5830	90	29	-	-	PUNCT
bam-5830	90	30	throughput	throughput	NOUN
bam-5830	90	31	approach	approach	NOUN
bam-5830	90	32	and	and	CCONJ
bam-5830	90	33	place	place	VERB
bam-5830	90	34	our	our	PRON
bam-5830	90	35	ongoing	ongoing	ADJ
bam-5830	90	36	results	result	NOUN
bam-5830	90	37	into	into	ADP
bam-5830	90	38	a	a	DET
bam-5830	90	39	genome	genome	NOUN
bam-5830	90	40	-	-	PUNCT
bam-5830	90	41	wide	wide	ADJ
bam-5830	90	42	setting	setting	NOUN
bam-5830	90	43	.	.	PUNCT
bam-5830	91	1	as	as	ADP
bam-5830	91	2	a	a	DET
bam-5830	91	3	final	final	ADJ
bam-5830	91	4	goal	goal	NOUN
bam-5830	91	5	,	,	PUNCT
bam-5830	91	6	the	the	DET
bam-5830	91	7	hypertrophic	hypertrophic	ADJ
bam-5830	91	8	/	/	SYM
bam-5830	91	9	dystrophic	dystrophic	ADJ
bam-5830	91	10	signatures	signature	NOUN
bam-5830	91	11	and	and	CCONJ
bam-5830	91	12	tissue	tissue	NOUN
bam-5830	91	13	-	-	PUNCT
bam-5830	91	14	specific	specific	ADJ
bam-5830	91	15	information	information	NOUN
bam-5830	91	16	will	will	AUX
bam-5830	91	17	further	far	ADV
bam-5830	91	18	be	be	AUX
bam-5830	91	19	integrated	integrate	VERB
bam-5830	91	20	to	to	PART
bam-5830	91	21	establish	establish	VERB
bam-5830	91	22	skeletal	skeletal	ADJ
bam-5830	91	23	and	and	CCONJ
bam-5830	91	24	cardiac	cardiac	ADV
bam-5830	91	25	-	-	PUNCT
bam-5830	91	26	enhancing	enhance	VERB
bam-5830	91	27	cocktails	cocktail	NOUN
bam-5830	91	28	to	to	PART
bam-5830	91	29	selectively	selectively	ADV
bam-5830	91	30	improve	improve	VERB
bam-5830	91	31	the	the	DET
bam-5830	91	32	regenerative	regenerative	ADJ
bam-5830	91	33	outcome	outcome	NOUN
bam-5830	91	34	of	of	ADP
bam-5830	91	35	patient	patient	NOUN
bam-5830	91	36	-	-	PUNCT
bam-5830	91	37	specific	specific	ADJ
bam-5830	91	38	progenitors	progenitor	NOUN
bam-5830	91	39	in	in	ADP
bam-5830	91	40	vivo	vivo	NOUN
bam-5830	91	41	,	,	PUNCT
bam-5830	91	42	into	into	ADP
bam-5830	91	43	a	a	DET
bam-5830	91	44	xenograft	xenograft	NOUN
bam-5830	91	45	-	-	PUNCT
bam-5830	91	46	permissive	permissive	ADJ
bam-5830	91	47	murine	murine	ADJ
bam-5830	91	48	model	model	NOUN
bam-5830	91	49	.	.	PUNCT
bam-5830	92	1	*	*	PUNCT
bam-5830	92	2	*	*	PUNCT
bam-5830	92	3	*	*	PUNCT
bam-5830	92	4	*	*	PUNCT
bam-5830	92	5	*	*	PUNCT
bam-5830	92	6	development	development	NOUN
bam-5830	92	7	of	of	ADP
bam-5830	92	8	a	a	DET
bam-5830	92	9	3d	3d	NUM
bam-5830	92	10	implantable	implantable	ADJ
bam-5830	92	11	niche	niche	NOUN
bam-5830	92	12	of	of	ADP
bam-5830	92	13	hipsc	hipsc	ADJ
bam-5830	92	14	-	-	PUNCT
bam-5830	92	15	derived	derive	VERB
bam-5830	92	16	satellite	satellite	NOUN
bam-5830	92	17	cells	cell	NOUN
bam-5830	92	18	e.	e.	PROPN
bam-5830	92	19	serena,1,2	serena,1,2	PROPN
bam-5830	92	20	,	,	PUNCT
bam-5830	92	21	s.	s.	PROPN
bam-5830	92	22	zatti	zatti	PROPN
bam-5830	92	23	1,2	1,2	NUM
bam-5830	92	24	,	,	PUNCT
bam-5830	92	25	n.	n.	NOUN
bam-5830	92	26	mattei	mattei	NOUN
bam-5830	92	27	1,2	1,2	NUM
bam-5830	92	28	,	,	PUNCT
bam-5830	92	29	m.	m.	NOUN
bam-5830	92	30	vetralla	vetralla	NOUN
bam-5830	92	31	1,2	1,2	NUM
bam-5830	92	32	,	,	PUNCT
bam-5830	92	33	s.	s.	PROPN
bam-5830	92	34	giulitti	giulitti	PROPN
bam-5830	92	35	1,2	1,2	NUM
bam-5830	92	36	,	,	PUNCT
bam-5830	92	37	g.	g.	PROPN
bam-5830	92	38	selmin	selmin	PROPN
bam-5830	92	39	1,2	1,2	NUM
bam-5830	92	40	,	,	PUNCT
bam-5830	92	41	e.	e.	PROPN
bam-5830	92	42	torchio	torchio	PROPN
bam-5830	92	43	1,2	1,2	NUM
bam-5830	92	44	,	,	PUNCT
bam-5830	92	45	l.	l.	PROPN
bam-5830	92	46	vitiello	vitiello	PROPN
bam-5830	92	47	3	3	NUM
bam-5830	92	48	,	,	PUNCT
bam-5830	92	49	n.	n.	PROPN
bam-5830	92	50	elvassore	elvassore	PROPN
bam-5830	92	51	1	1	NUM
bam-5830	92	52	1	1	NUM
bam-5830	92	53	.	.	PUNCT
bam-5830	92	54	industrial	industrial	ADJ
bam-5830	92	55	engineering	engineering	PROPN
bam-5830	92	56	department	department	PROPN
bam-5830	92	57	,	,	PUNCT
bam-5830	92	58	university	university	PROPN
bam-5830	92	59	of	of	ADP
bam-5830	92	60	padova	padova	PROPN
bam-5830	92	61	,	,	PUNCT
bam-5830	92	62	italy	italy	PROPN
bam-5830	92	63	;	;	PUNCT
bam-5830	92	64	2	2	NUM
bam-5830	92	65	,	,	PUNCT
bam-5830	92	66	venetian	venetian	ADJ
bam-5830	92	67	institute	institute	NOUN
bam-5830	92	68	of	of	ADP
bam-5830	92	69	molecular	molecular	ADJ
bam-5830	92	70	medicine	medicine	NOUN
bam-5830	92	71	,	,	PUNCT
bam-5830	92	72	padova	padova	PROPN
bam-5830	92	73	,	,	PUNCT
bam-5830	92	74	italy	italy	PROPN
bam-5830	92	75	;	;	PUNCT
bam-5830	92	76	3	3	NUM
bam-5830	92	77	,	,	PUNCT
bam-5830	92	78	department	department	NOUN
bam-5830	92	79	of	of	ADP
bam-5830	92	80	biology	biology	NOUN
bam-5830	92	81	,	,	PUNCT
bam-5830	92	82	university	university	PROPN
bam-5830	92	83	of	of	ADP
bam-5830	92	84	padova	padova	PROPN
bam-5830	92	85	,	,	PUNCT
bam-5830	92	86	italy	italy	PROPN
bam-5830	92	87	.	.	PUNCT
bam-5830	93	1	e	e	X
bam-5830	93	2	-	-	NOUN
bam-5830	93	3	mail	mail	NOUN
bam-5830	93	4	:	:	PUNCT
bam-5830	93	5	elena.serena@unipd.it	elena.serena@unipd.it	PROPN
bam-5830	93	6	duchenne	duchenne	NOUN
bam-5830	93	7	muscular	muscular	ADJ
bam-5830	93	8	dystrophy	dystrophy	NOUN
bam-5830	93	9	(	(	PUNCT
bam-5830	93	10	dmd	dmd	NOUN
bam-5830	93	11	)	)	PUNCT
bam-5830	93	12	is	be	AUX
bam-5830	93	13	the	the	DET
bam-5830	93	14	most	most	ADV
bam-5830	93	15	common	common	ADJ
bam-5830	93	16	,	,	PUNCT
bam-5830	93	17	lethal	lethal	ADJ
bam-5830	93	18	,	,	PUNCT
bam-5830	93	19	inherited	inherit	VERB
bam-5830	93	20	myopathy	myopathy	ADJ
bam-5830	93	21	,	,	PUNCT
bam-5830	93	22	which	which	PRON
bam-5830	93	23	results	result	VERB
bam-5830	93	24	in	in	ADP
bam-5830	93	25	muscle	muscle	NOUN
bam-5830	93	26	degeneration	degeneration	NOUN
bam-5830	93	27	.	.	PUNCT
bam-5830	94	1	in	in	ADP
bam-5830	94	2	this	this	DET
bam-5830	94	3	work	work	NOUN
bam-5830	94	4	,	,	PUNCT
bam-5830	94	5	we	we	PRON
bam-5830	94	6	aimed	aim	VERB
bam-5830	94	7	at	at	ADP
bam-5830	94	8	developing	develop	VERB
bam-5830	94	9	an	an	DET
bam-5830	94	10	innovative	innovative	ADJ
bam-5830	94	11	3d	3d	NOUN
bam-5830	94	12	satellite	satellite	NOUN
bam-5830	94	13	cell	cell	NOUN
bam-5830	94	14	niche	niche	NOUN
bam-5830	94	15	derived	derive	VERB
bam-5830	94	16	from	from	ADP
bam-5830	94	17	human	human	ADJ
bam-5830	94	18	induced	induce	VERB
bam-5830	94	19	pluripotent	pluripotent	ADJ
bam-5830	94	20	stem	stem	NOUN
bam-5830	94	21	cells	cell	NOUN
bam-5830	94	22	(	(	PUNCT
bam-5830	94	23	hipsc	hipsc	NOUN
bam-5830	94	24	)	)	PUNCT
bam-5830	94	25	within	within	ADP
bam-5830	94	26	their	their	PRON
bam-5830	94	27	native	native	ADJ
bam-5830	94	28	sublaminal	sublaminal	ADJ
bam-5830	94	29	position	position	NOUN
bam-5830	94	30	in	in	ADP
bam-5830	94	31	an	an	DET
bam-5830	94	32	engineered	engineer	VERB
bam-5830	94	33	human	human	ADJ
bam-5830	94	34	skeletal	skeletal	ADJ
bam-5830	94	35	muscle	muscle	NOUN
bam-5830	94	36	myofiber	myofiber	NOUN
bam-5830	94	37	.	.	PUNCT
bam-5830	95	1	one	one	NUM
bam-5830	95	2	of	of	ADP
bam-5830	95	3	the	the	DET
bam-5830	95	4	main	main	ADJ
bam-5830	95	5	limitations	limitation	NOUN
bam-5830	95	6	of	of	ADP
bam-5830	95	7	cell	cell	NOUN
bam-5830	95	8	therapy	therapy	NOUN
bam-5830	95	9	for	for	ADP
bam-5830	95	10	dmd	dmd	NOUN
bam-5830	95	11	is	be	AUX
bam-5830	95	12	the	the	DET
bam-5830	95	13	high	high	ADJ
bam-5830	95	14	number	number	NOUN
bam-5830	95	15	of	of	ADP
bam-5830	95	16	myogenic	myogenic	ADJ
bam-5830	95	17	cells	cell	NOUN
bam-5830	95	18	required	require	VERB
bam-5830	95	19	and	and	CCONJ
bam-5830	95	20	the	the	DET
bam-5830	95	21	efficiency	efficiency	NOUN
bam-5830	95	22	of	of	ADP
bam-5830	95	23	engraftment	engraftment	NOUN
bam-5830	95	24	in	in	ADP
bam-5830	95	25	vivo	vivo	NOUN
bam-5830	95	26	.	.	PUNCT
bam-5830	96	1	hipsc	hipsc	PROPN
bam-5830	96	2	ensure	ensure	VERB
bam-5830	96	3	large	large	ADJ
bam-5830	96	4	amount	amount	NOUN
bam-5830	96	5	of	of	ADP
bam-5830	96	6	cells	cell	NOUN
bam-5830	96	7	and	and	CCONJ
bam-5830	96	8	the	the	DET
bam-5830	96	9	possibility	possibility	NOUN
bam-5830	96	10	of	of	ADP
bam-5830	96	11	derive	derive	ADJ
bam-5830	96	12	patient	patient	NOUN
bam-5830	96	13	-	-	PUNCT
bam-5830	96	14	specific	specific	ADJ
bam-5830	96	15	cells	cell	NOUN
bam-5830	96	16	,	,	PUNCT
bam-5830	96	17	but	but	CCONJ
bam-5830	96	18	obtaining	obtain	VERB
bam-5830	96	19	myogenic	myogenic	ADJ
bam-5830	96	20	cells	cell	NOUN
bam-5830	96	21	in	in	ADP
bam-5830	96	22	vitro	vitro	X
bam-5830	96	23	from	from	ADP
bam-5830	96	24	hipsc	hipsc	ADJ
bam-5830	96	25	is	be	AUX
bam-5830	96	26	difficult	difficult	ADJ
bam-5830	96	27	and	and	CCONJ
bam-5830	96	28	the	the	DET
bam-5830	96	29	yield	yield	NOUN
bam-5830	96	30	is	be	AUX
bam-5830	96	31	low	low	ADJ
bam-5830	96	32	.	.	PUNCT
bam-5830	97	1	in	in	ADP
bam-5830	97	2	this	this	DET
bam-5830	97	3	work	work	NOUN
bam-5830	97	4	,	,	PUNCT
bam-5830	97	5	we	we	PRON
bam-5830	97	6	induced	induce	VERB
bam-5830	97	7	the	the	DET
bam-5830	97	8	myogenic	myogenic	ADJ
bam-5830	97	9	differentiation	differentiation	NOUN
bam-5830	97	10	of	of	ADP
bam-5830	97	11	hipsc	hipsc	NOUN
bam-5830	97	12	through	through	ADP
bam-5830	97	13	multiple	multiple	ADJ
bam-5830	97	14	transfection	transfection	NOUN
bam-5830	97	15	of	of	ADP
bam-5830	97	16	modified	modified	ADJ
bam-5830	97	17	mrna	mrna	NOUN
bam-5830	97	18	of	of	ADP
bam-5830	97	19	the	the	DET
bam-5830	97	20	master	master	NOUN
bam-5830	97	21	transcription	transcription	NOUN
bam-5830	97	22	factors	factor	NOUN
bam-5830	97	23	myod	myod	NOUN
bam-5830	97	24	,	,	PUNCT
bam-5830	97	25	pax3	pax3	NOUN
bam-5830	97	26	and	and	CCONJ
bam-5830	97	27	pax7	pax7	PROPN
bam-5830	97	28	.	.	PUNCT
bam-5830	98	1	to	to	ADP
bam-5830	98	2	this	this	DET
bam-5830	98	3	aim	aim	NOUN
bam-5830	98	4	,	,	PUNCT
bam-5830	98	5	we	we	PRON
bam-5830	98	6	exploited	exploit	VERB
bam-5830	98	7	a	a	DET
bam-5830	98	8	microfluidic	microfluidic	ADJ
bam-5830	98	9	platform	platform	NOUN
bam-5830	98	10	that	that	PRON
bam-5830	98	11	allows	allow	VERB
bam-5830	98	12	the	the	DET
bam-5830	98	13	downscaling	downscaling	NOUN
bam-5830	98	14	of	of	ADP
bam-5830	98	15	the	the	DET
bam-5830	98	16	process	process	NOUN
bam-5830	98	17	for	for	ADP
bam-5830	98	18	performing	perform	VERB
bam-5830	98	19	cost	cost	NOUN
bam-5830	98	20	-	-	PUNCT
bam-5830	98	21	effective	effective	ADJ
bam-5830	98	22	,	,	PUNCT
bam-5830	98	23	multiparametric	multiparametric	ADJ
bam-5830	98	24	and	and	CCONJ
bam-5830	98	25	highthroughput	highthroughput	VERB
bam-5830	98	26	experimental	experimental	ADJ
bam-5830	98	27	investigations	investigation	NOUN
bam-5830	98	28	.	.	PUNCT
bam-5830	99	1	we	we	PRON
bam-5830	99	2	optimized	optimize	VERB
bam-5830	99	3	the	the	DET
bam-5830	99	4	protocol	protocol	NOUN
bam-5830	99	5	for	for	ADP
bam-5830	99	6	transfecting	transfecte	VERB
bam-5830	99	7	hipsc	hipsc	ADJ
bam-5830	99	8	colonies	colony	NOUN
bam-5830	99	9	leading	lead	VERB
bam-5830	99	10	to	to	ADP
bam-5830	99	11	a	a	DET
bam-5830	99	12	transfection	transfection	NOUN
bam-5830	99	13	efficiency	efficiency	NOUN
bam-5830	99	14	of	of	ADP
bam-5830	99	15	60	60	NUM
bam-5830	99	16	%	%	NOUN
bam-5830	99	17	per	per	ADP
bam-5830	99	18	single	single	ADJ
bam-5830	99	19	transfection	transfection	NOUN
bam-5830	99	20	.	.	PUNCT
bam-5830	100	1	after	after	ADP
bam-5830	100	2	multiple	multiple	ADJ
bam-5830	100	3	transfections	transfection	NOUN
bam-5830	100	4	,	,	PUNCT
bam-5830	100	5	exogenous	exogenous	ADJ
bam-5830	100	6	myod	myod	NOUN
bam-5830	100	7	is	be	AUX
bam-5830	100	8	expressed	express	VERB
bam-5830	100	9	in	in	ADP
bam-5830	100	10	95	95	NUM
bam-5830	100	11	%	%	NOUN
bam-5830	100	12	of	of	ADP
bam-5830	100	13	the	the	DET
bam-5830	100	14	cells	cell	NOUN
bam-5830	100	15	and	and	CCONJ
bam-5830	100	16	endogenous	endogenous	ADJ
bam-5830	100	17	expression	expression	NOUN
bam-5830	100	18	of	of	ADP
bam-5830	100	19	desmin	desmin	ADJ
bam-5830	100	20	and	and	CCONJ
bam-5830	100	21	myosin	myosin	PROPN
bam-5830	100	22	heavy	heavy	PROPN
bam-5830	100	23	chain	chain	NOUN
bam-5830	100	24	was	be	AUX
bam-5830	100	25	observed	observe	VERB
bam-5830	100	26	(	(	PUNCT
bam-5830	100	27	4	4	NUM
bam-5830	100	28	days	day	NOUN
bam-5830	100	29	after	after	ADP
bam-5830	100	30	the	the	DET
bam-5830	100	31	last	last	ADJ
bam-5830	100	32	transfection	transfection	NOUN
bam-5830	100	33	)	)	PUNCT
bam-5830	100	34	.	.	PUNCT
bam-5830	101	1	ongoing	ongoing	ADJ
bam-5830	101	2	experiments	experiment	NOUN
bam-5830	101	3	are	be	AUX
bam-5830	101	4	extending	extend	VERB
bam-5830	101	5	these	these	DET
bam-5830	101	6	results	result	NOUN
bam-5830	101	7	to	to	ADP
bam-5830	101	8	pax3	pax3	NOUN
bam-5830	101	9	and	and	CCONJ
bam-5830	101	10	pax7	pax7	PROPN
bam-5830	101	11	.	.	PUNCT
bam-5830	102	1	another	another	DET
bam-5830	102	2	key	key	ADJ
bam-5830	102	3	factor	factor	NOUN
bam-5830	102	4	for	for	ADP
bam-5830	102	5	a	a	DET
bam-5830	102	6	successful	successful	ADJ
bam-5830	102	7	cell	cell	NOUN
bam-5830	102	8	therapy	therapy	NOUN
bam-5830	102	9	is	be	AUX
bam-5830	102	10	the	the	DET
bam-5830	102	11	cell	cell	NOUN
bam-5830	102	12	delivery	delivery	NOUN
bam-5830	102	13	.	.	PUNCT
bam-5830	103	1	in	in	ADP
bam-5830	103	2	this	this	DET
bam-5830	103	3	sight	sight	NOUN
bam-5830	103	4	,	,	PUNCT
bam-5830	103	5	we	we	PRON
bam-5830	103	6	developed	develop	VERB
bam-5830	103	7	a	a	DET
bam-5830	103	8	3d	3d	NUM
bam-5830	103	9	poly	poly	ADJ
bam-5830	103	10	-	-	PUNCT
bam-5830	103	11	acrilammide	acrilammide	NOUN
bam-5830	103	12	/	/	SYM
bam-5830	103	13	hyaluronic	hyaluronic	ADJ
bam-5830	103	14	acid	acid	NOUN
bam-5830	103	15	hydrogel	hydrogel	NOUN
bam-5830	103	16	(	(	PUNCT
bam-5830	103	17	hy	hy	NOUN
bam-5830	103	18	)	)	PUNCT
bam-5830	103	19	scaffold	scaffold	NOUN
bam-5830	103	20	and	and	CCONJ
bam-5830	103	21	optimized	optimize	VERB
bam-5830	103	22	its	its	PRON
bam-5830	103	23	biochemical	biochemical	ADJ
bam-5830	103	24	and	and	CCONJ
bam-5830	103	25	mechanical	mechanical	ADJ
bam-5830	103	26	properties	property	NOUN
bam-5830	103	27	in	in	ADP
bam-5830	103	28	order	order	NOUN
bam-5830	103	29	to	to	PART
bam-5830	103	30	sustain	sustain	VERB
bam-5830	103	31	the	the	DET
bam-5830	103	32	myogenic	myogenic	ADJ
bam-5830	103	33	differentiation	differentiation	NOUN
bam-5830	103	34	of	of	ADP
bam-5830	103	35	human	human	ADJ
bam-5830	103	36	primary	primary	ADJ
bam-5830	103	37	myoblasts	myoblast	NOUN
bam-5830	103	38	and	and	CCONJ
bam-5830	103	39	to	to	PART
bam-5830	103	40	reproduce	reproduce	VERB
bam-5830	103	41	the	the	DET
bam-5830	103	42	protective	protective	ADJ
bam-5830	103	43	microenvironment	microenvironment	NOUN
bam-5830	103	44	of	of	ADP
bam-5830	103	45	the	the	DET
bam-5830	103	46	satellite	satellite	NOUN
bam-5830	103	47	cell	cell	NOUN
bam-5830	103	48	niche	niche	NOUN
bam-5830	103	49	.	.	PUNCT
bam-5830	104	1	the	the	DET
bam-5830	104	2	scaffold	scaffold	NOUN
bam-5830	104	3	was	be	AUX
bam-5830	104	4	designed	design	VERB
bam-5830	104	5	in	in	ADP
bam-5830	104	6	order	order	NOUN
bam-5830	104	7	to	to	PART
bam-5830	104	8	control	control	VERB
bam-5830	104	9	the	the	DET
bam-5830	104	10	cell	cell	NOUN
bam-5830	104	11	topology	topology	NOUN
bam-5830	104	12	:	:	PUNCT
bam-5830	104	13	3d	3d	PROPN
bam-5830	104	14	parallel	parallel	PROPN
bam-5830	104	15	micro	micro	NOUN
bam-5830	104	16	-	-	NOUN
bam-5830	104	17	channels	channel	NOUN
bam-5830	104	18	(	(	PUNCT
bam-5830	104	19	80	80	NUM
bam-5830	104	20	-	-	SYM
bam-5830	104	21	160	160	NUM
bam-5830	104	22	μm	μm	NOUN
bam-5830	104	23	in	in	ADP
bam-5830	104	24	diameter	diameter	NOUN
bam-5830	104	25	,	,	PUNCT
bam-5830	104	26	10	10	NUM
bam-5830	104	27	-	-	SYM
bam-5830	104	28	15	15	NUM
bam-5830	104	29	mm	mm	NOUN
bam-5830	104	30	long	long	ADJ
bam-5830	104	31	)	)	PUNCT
bam-5830	104	32	were	be	AUX
bam-5830	104	33	produced	produce	VERB
bam-5830	104	34	inside	inside	ADP
bam-5830	104	35	the	the	DET
bam-5830	104	36	scaffold	scaffold	NOUN
bam-5830	104	37	and	and	CCONJ
bam-5830	104	38	functionalized	functionalize	VERB
bam-5830	104	39	with	with	ADP
bam-5830	104	40	ecm	ecm	NOUN
bam-5830	104	41	proteins	protein	NOUN
bam-5830	104	42	.	.	PUNCT
bam-5830	105	1	to	to	PART
bam-5830	105	2	reproduce	reproduce	VERB
bam-5830	105	3	the	the	DET
bam-5830	105	4	physiological	physiological	ADJ
bam-5830	105	5	abstracts	abstract	NOUN
bam-5830	105	6	of	of	ADP
bam-5830	105	7	the	the	DET
bam-5830	105	8	xii	xii	PROPN
bam-5830	105	9	iim	iim	NOUN
bam-5830	105	10	myology	myology	NOUN
bam-5830	105	11	meeting	meeting	NOUN
bam-5830	105	12	october	october	PROPN
bam-5830	105	13	1–4	1–4	PROPN
bam-5830	105	14	,	,	PUNCT
bam-5830	105	15	2015	2015	NUM
bam-5830	105	16	eur	eur	PROPN
bam-5830	105	17	j	j	PROPN
bam-5830	105	18	transl	transl	PROPN
bam-5830	105	19	myol	myol	PROPN
bam-5830	105	20	basic	basic	ADJ
bam-5830	105	21	appl	appl	NOUN
bam-5830	105	22	myol	myol	NOUN
bam-5830	105	23	2016	2016	NUM
bam-5830	105	24	;	;	PUNCT
bam-5830	105	25	26	26	NUM
bam-5830	105	26	(	(	PUNCT
bam-5830	105	27	1):2	1):2	NUM
bam-5830	105	28	-	-	SYM
bam-5830	105	29	24	24	NUM
bam-5830	105	30	this	this	DET
bam-5830	105	31	article	article	NOUN
bam-5830	105	32	is	be	AUX
bam-5830	105	33	distributed	distribute	VERB
bam-5830	105	34	under	under	ADP
bam-5830	105	35	the	the	DET
bam-5830	105	36	terms	term	NOUN
bam-5830	105	37	of	of	ADP
bam-5830	105	38	the	the	DET
bam-5830	105	39	creative	creative	ADJ
bam-5830	105	40	commons	common	NOUN
bam-5830	105	41	attribution	attribution	NOUN
bam-5830	105	42	noncommercial	noncommercial	ADJ
bam-5830	105	43	license	license	NOUN
bam-5830	105	44	(	(	PUNCT
bam-5830	105	45	cc	cc	NOUN
bam-5830	105	46	by	by	ADP
bam-5830	105	47	-	-	PUNCT
bam-5830	105	48	nc	nc	PROPN
bam-5830	105	49	4.0	4.0	NUM
bam-5830	105	50	)	)	PUNCT
bam-5830	105	51	which	which	PRON
bam-5830	105	52	permits	permit	VERB
bam-5830	105	53	any	any	DET
bam-5830	105	54	noncommercial	noncommercial	ADJ
bam-5830	105	55	use	use	NOUN
bam-5830	105	56	,	,	PUNCT
bam-5830	105	57	distribution	distribution	NOUN
bam-5830	105	58	,	,	PUNCT
bam-5830	105	59	and	and	CCONJ
bam-5830	105	60	reproduction	reproduction	NOUN
bam-5830	105	61	in	in	ADP
bam-5830	105	62	any	any	DET
bam-5830	105	63	medium	medium	NOUN
bam-5830	105	64	,	,	PUNCT
bam-5830	105	65	provided	provide	VERB
bam-5830	105	66	the	the	DET
bam-5830	105	67	original	original	ADJ
bam-5830	105	68	author(s	author(s	NOUN
bam-5830	105	69	)	)	PUNCT
bam-5830	105	70	and	and	CCONJ
bam-5830	105	71	source	source	NOUN
bam-5830	105	72	are	be	AUX
bam-5830	105	73	credited	credit	VERB
bam-5830	105	74	.	.	PUNCT
bam-5830	106	1	6	6	NUM
bam-5830	106	2	mechanobiology	mechanobiology	NOUN
bam-5830	106	3	,	,	PUNCT
bam-5830	106	4	hy	hy	PROPN
bam-5830	106	5	chemical	chemical	NOUN
bam-5830	106	6	composition	composition	NOUN
bam-5830	106	7	was	be	AUX
bam-5830	106	8	optimized	optimize	VERB
bam-5830	106	9	in	in	ADP
bam-5830	106	10	order	order	NOUN
bam-5830	106	11	to	to	PART
bam-5830	106	12	obtain	obtain	VERB
bam-5830	106	13	a	a	DET
bam-5830	106	14	soft	soft	ADJ
bam-5830	106	15	scaffold	scaffold	NOUN
bam-5830	106	16	with	with	ADP
bam-5830	106	17	physiological	physiological	ADJ
bam-5830	106	18	elastic	elastic	ADJ
bam-5830	106	19	modulus	modulus	NOUN
bam-5830	106	20	,	,	PUNCT
bam-5830	106	21	e≈12±4kpa	e≈12±4kpa	PUNCT
bam-5830	106	22	.	.	PUNCT
bam-5830	107	1	human	human	ADJ
bam-5830	107	2	primary	primary	ADJ
bam-5830	107	3	myoblasts	myoblast	NOUN
bam-5830	107	4	were	be	AUX
bam-5830	107	5	used	use	VERB
bam-5830	107	6	to	to	PART
bam-5830	107	7	optimize	optimize	VERB
bam-5830	107	8	the	the	DET
bam-5830	107	9	seeding	seeding	NOUN
bam-5830	107	10	,	,	PUNCT
bam-5830	107	11	culture	culture	NOUN
bam-5830	107	12	and	and	CCONJ
bam-5830	107	13	differentiation	differentiation	NOUN
bam-5830	107	14	protocols	protocol	NOUN
bam-5830	107	15	.	.	PUNCT
bam-5830	108	1	at	at	ADP
bam-5830	108	2	10	10	NUM
bam-5830	108	3	days	day	NOUN
bam-5830	108	4	,	,	PUNCT
bam-5830	108	5	we	we	PRON
bam-5830	108	6	observed	observe	VERB
bam-5830	108	7	tightly	tightly	ADV
bam-5830	108	8	packed	pack	VERB
bam-5830	108	9	myotubes	myotube	NOUN
bam-5830	108	10	bundles	bundle	NOUN
bam-5830	108	11	,	,	PUNCT
bam-5830	108	12	expressing	express	VERB
bam-5830	108	13	myosin	myosin	PROPN
bam-5830	108	14	heavy	heavy	PROPN
bam-5830	108	15	chain	chain	NOUN
bam-5830	108	16	,	,	PUNCT
bam-5830	108	17	α	α	NOUN
bam-5830	108	18	-	-	NOUN
bam-5830	108	19	actinin	actinin	NOUN
bam-5830	108	20	and	and	CCONJ
bam-5830	108	21	dystrophin	dystrophin	NOUN
bam-5830	108	22	.	.	PUNCT
bam-5830	109	1	we	we	PRON
bam-5830	109	2	are	be	AUX
bam-5830	109	3	now	now	ADV
bam-5830	109	4	integrating	integrate	VERB
bam-5830	109	5	hesc	hesc	NOUN
bam-5830	109	6	-	-	PUNCT
bam-5830	109	7	derived	derive	VERB
bam-5830	109	8	myoblast	myoblast	NOUN
bam-5830	109	9	and	and	CCONJ
bam-5830	109	10	we	we	PRON
bam-5830	109	11	observed	observe	VERB
bam-5830	109	12	differentiation	differentiation	NOUN
bam-5830	109	13	into	into	ADP
bam-5830	109	14	myoubes	myoube	NOUN
bam-5830	109	15	and	and	CCONJ
bam-5830	109	16	expression	expression	NOUN
bam-5830	109	17	of	of	ADP
bam-5830	109	18	myosin	myosin	PROPN
bam-5830	109	19	heavy	heavy	ADJ
bam-5830	109	20	chai	chai	NOUN
bam-5830	109	21	,	,	PUNCT
bam-5830	109	22	α	α	NOUN
bam-5830	109	23	-	-	NOUN
bam-5830	109	24	actinin	actinin	NOUN
bam-5830	109	25	and	and	CCONJ
bam-5830	109	26	desmin.we	desmin.we	PRON
bam-5830	109	27	hypothesize	hypothesize	VERB
bam-5830	109	28	that	that	SCONJ
bam-5830	109	29	such	such	ADJ
bam-5830	109	30	engineered	engineer	VERB
bam-5830	109	31	niche	niche	NOUN
bam-5830	109	32	will	will	AUX
bam-5830	109	33	provide	provide	VERB
bam-5830	109	34	,	,	PUNCT
bam-5830	109	35	upon	upon	SCONJ
bam-5830	109	36	in	in	ADP
bam-5830	109	37	vivo	vivo	ADJ
bam-5830	109	38	implantation	implantation	NOUN
bam-5830	109	39	,	,	PUNCT
bam-5830	109	40	satellite	satellite	NOUN
bam-5830	109	41	cells	cell	NOUN
bam-5830	109	42	able	able	ADJ
bam-5830	109	43	to	to	PART
bam-5830	109	44	regenerate	regenerate	VERB
bam-5830	109	45	the	the	DET
bam-5830	109	46	damaged	damage	VERB
bam-5830	109	47	muscle	muscle	NOUN
bam-5830	109	48	of	of	ADP
bam-5830	109	49	dmd	dmd	NOUN
bam-5830	109	50	patients	patient	NOUN
bam-5830	109	51	,	,	PUNCT
bam-5830	109	52	and	and	CCONJ
bam-5830	109	53	reconstitute	reconstitute	VERB
bam-5830	109	54	the	the	DET
bam-5830	109	55	stem	stem	NOUN
bam-5830	109	56	cell	cell	NOUN
bam-5830	109	57	pool	pool	NOUN
bam-5830	109	58	for	for	ADP
bam-5830	109	59	future	future	ADJ
bam-5830	109	60	muscle	muscle	NOUN
bam-5830	109	61	damages	damage	NOUN
bam-5830	109	62	.	.	PUNCT
bam-5830	110	1	on	on	ADP
bam-5830	110	2	the	the	DET
bam-5830	110	3	other	other	ADJ
bam-5830	110	4	hand	hand	NOUN
bam-5830	110	5	,	,	PUNCT
bam-5830	110	6	our	our	PRON
bam-5830	110	7	3d	3d	ADJ
bam-5830	110	8	niche	niche	NOUN
bam-5830	110	9	could	could	AUX
bam-5830	110	10	be	be	AUX
bam-5830	110	11	exploited	exploit	VERB
bam-5830	110	12	as	as	ADP
bam-5830	110	13	an	an	DET
bam-5830	110	14	in	in	ADP
bam-5830	110	15	vitro	vitro	X
bam-5830	110	16	tool	tool	NOUN
bam-5830	110	17	to	to	PART
bam-5830	110	18	study	study	VERB
bam-5830	110	19	the	the	DET
bam-5830	110	20	biology	biology	NOUN
bam-5830	110	21	of	of	ADP
bam-5830	110	22	the	the	DET
bam-5830	110	23	niche	niche	NOUN
bam-5830	110	24	itself	itself	PRON
bam-5830	110	25	,	,	PUNCT
bam-5830	110	26	the	the	DET
bam-5830	110	27	mechanism	mechanism	NOUN
bam-5830	110	28	of	of	ADP
bam-5830	110	29	the	the	DET
bam-5830	110	30	pathology	pathology	NOUN
bam-5830	110	31	or	or	CCONJ
bam-5830	110	32	as	as	ADP
bam-5830	110	33	a	a	DET
bam-5830	110	34	tool	tool	NOUN
bam-5830	110	35	for	for	ADP
bam-5830	110	36	testing	test	VERB
bam-5830	110	37	new	new	ADJ
bam-5830	110	38	drugs	drug	NOUN
bam-5830	110	39	and	and	CCONJ
bam-5830	110	40	therapies	therapy	NOUN
bam-5830	110	41	in	in	ADP
bam-5830	110	42	a	a	DET
bam-5830	110	43	personalized	personalized	ADJ
bam-5830	110	44	manner	manner	NOUN
bam-5830	110	45	.	.	PUNCT
bam-5830	111	1	*	*	PUNCT
bam-5830	111	2	*	*	PUNCT
bam-5830	111	3	*	*	PUNCT
bam-5830	111	4	*	*	PUNCT
bam-5830	111	5	*	*	PUNCT
bam-5830	111	6	a	a	DET
bam-5830	111	7	stem	stem	NOUN
bam-5830	111	8	cell	cell	NOUN
bam-5830	111	9	niche	niche	NOUN
bam-5830	111	10	in	in	ADP
bam-5830	111	11	the	the	DET
bam-5830	111	12	dish	dish	NOUN
bam-5830	111	13	m.	m.	NOUN
bam-5830	111	14	marinkovic	marinkovic	PROPN
bam-5830	111	15	,	,	PUNCT
bam-5830	111	16	t.	t.	NOUN
bam-5830	111	17	pavlidou	pavlidou	NOUN
bam-5830	111	18	,	,	PUNCT
bam-5830	111	19	l.	l.	PROPN
bam-5830	111	20	castagnoli	castagnoli	PROPN
bam-5830	111	21	,	,	PUNCT
bam-5830	111	22	c.	c.	PROPN
bam-5830	111	23	gargioli	gargioli	PROPN
bam-5830	111	24	,	,	PUNCT
bam-5830	111	25	g.	g.	PROPN
bam-5830	111	26	cesareni	cesareni	PROPN
bam-5830	111	27	department	department	PROPN
bam-5830	111	28	of	of	ADP
bam-5830	111	29	biology	biology	NOUN
bam-5830	111	30	,	,	PUNCT
bam-5830	111	31	rome	rome	PROPN
bam-5830	111	32	university	university	NOUN
bam-5830	111	33	tor	tor	PROPN
bam-5830	111	34	vergata	vergata	PROPN
bam-5830	111	35	,	,	PUNCT
bam-5830	111	36	italy	italy	PROPN
bam-5830	111	37	e	e	PROPN
bam-5830	111	38	-	-	NOUN
bam-5830	111	39	mail	mail	NOUN
bam-5830	111	40	:	:	PUNCT
bam-5830	111	41	cesareni@uniroma2.it	cesareni@uniroma2.it	PROPN
bam-5830	111	42	skeletal	skeletal	ADJ
bam-5830	111	43	muscle	muscle	NOUN
bam-5830	111	44	regeneration	regeneration	NOUN
bam-5830	111	45	is	be	AUX
bam-5830	111	46	mediated	mediate	VERB
bam-5830	111	47	by	by	ADP
bam-5830	111	48	a	a	DET
bam-5830	111	49	complex	complex	ADJ
bam-5830	111	50	crosstalk	crosstalk	NOUN
bam-5830	111	51	between	between	ADP
bam-5830	111	52	various	various	ADJ
bam-5830	111	53	resident	resident	ADJ
bam-5830	111	54	mononucleated	mononucleate	VERB
bam-5830	111	55	cell	cell	NOUN
bam-5830	111	56	populations	population	NOUN
bam-5830	111	57	.	.	PUNCT
bam-5830	112	1	these	these	DET
bam-5830	112	2	cell	cell	NOUN
bam-5830	112	3	interactions	interaction	NOUN
bam-5830	112	4	after	after	SCONJ
bam-5830	112	5	fiber	fiber	NOUN
bam-5830	112	6	damage	damage	NOUN
bam-5830	112	7	or	or	CCONJ
bam-5830	112	8	stress	stress	NOUN
bam-5830	112	9	are	be	AUX
bam-5830	112	10	finely	finely	ADV
bam-5830	112	11	regulated	regulate	VERB
bam-5830	112	12	in	in	ADP
bam-5830	112	13	time	time	NOUN
bam-5830	112	14	and	and	CCONJ
bam-5830	112	15	space	space	NOUN
bam-5830	112	16	.	.	PUNCT
bam-5830	113	1	satellite	satellite	NOUN
bam-5830	113	2	cells	cell	NOUN
bam-5830	113	3	,	,	PUNCT
bam-5830	113	4	skeletal	skeletal	ADJ
bam-5830	113	5	muscle	muscle	NOUN
bam-5830	113	6	stem	stem	NOUN
bam-5830	113	7	cells	cell	NOUN
bam-5830	113	8	,	,	PUNCT
bam-5830	113	9	play	play	VERB
bam-5830	113	10	a	a	DET
bam-5830	113	11	pivotal	pivotal	ADJ
bam-5830	113	12	role	role	NOUN
bam-5830	113	13	during	during	ADP
bam-5830	113	14	regeneration	regeneration	NOUN
bam-5830	113	15	being	be	AUX
bam-5830	113	16	the	the	DET
bam-5830	113	17	main	main	ADJ
bam-5830	113	18	source	source	NOUN
bam-5830	113	19	of	of	ADP
bam-5830	113	20	new	new	ADJ
bam-5830	113	21	myoblasts	myoblast	NOUN
bam-5830	113	22	.	.	PUNCT
bam-5830	114	1	however	however	ADV
bam-5830	114	2	,	,	PUNCT
bam-5830	114	3	their	their	PRON
bam-5830	114	4	activation	activation	NOUN
bam-5830	114	5	,	,	PUNCT
bam-5830	114	6	proliferation	proliferation	NOUN
bam-5830	114	7	and	and	CCONJ
bam-5830	114	8	differentiation	differentiation	NOUN
bam-5830	114	9	relies	rely	VERB
bam-5830	114	10	on	on	ADP
bam-5830	114	11	environmental	environmental	ADJ
bam-5830	114	12	cues	cue	NOUN
bam-5830	114	13	shaped	shape	VERB
bam-5830	114	14	by	by	ADP
bam-5830	114	15	cell	cell	NOUN
bam-5830	114	16	populations	population	NOUN
bam-5830	114	17	such	such	ADJ
bam-5830	114	18	as	as	ADP
bam-5830	114	19	macrophages	macrophage	NOUN
bam-5830	114	20	,	,	PUNCT
bam-5830	114	21	pericytes	pericyte	NOUN
bam-5830	114	22	,	,	PUNCT
bam-5830	114	23	and	and	CCONJ
bam-5830	114	24	fibro	fibro	PROPN
bam-5830	114	25	-	-	PUNCT
bam-5830	114	26	adipogenic	adipogenic	ADJ
bam-5830	114	27	progenitors	progenitor	NOUN
bam-5830	114	28	(	(	PUNCT
bam-5830	114	29	faps	fap	NOUN
bam-5830	114	30	)	)	PUNCT
bam-5830	114	31	.	.	PUNCT
bam-5830	115	1	faps	fap	NOUN
bam-5830	115	2	have	have	VERB
bam-5830	115	3	a	a	DET
bam-5830	115	4	leading	lead	VERB
bam-5830	115	5	role	role	NOUN
bam-5830	115	6	in	in	ADP
bam-5830	115	7	the	the	DET
bam-5830	115	8	regeneration	regeneration	NOUN
bam-5830	115	9	process	process	NOUN
bam-5830	115	10	since	since	SCONJ
bam-5830	115	11	they	they	PRON
bam-5830	115	12	promote	promote	VERB
bam-5830	115	13	myotube	myotube	NOUN
bam-5830	115	14	formation	formation	NOUN
bam-5830	115	15	by	by	ADP
bam-5830	115	16	positively	positively	ADV
bam-5830	115	17	regulating	regulate	VERB
bam-5830	115	18	satellite	satellite	NOUN
bam-5830	115	19	cell	cell	NOUN
bam-5830	115	20	differentiation	differentiation	NOUN
bam-5830	115	21	.	.	PUNCT
bam-5830	116	1	however	however	ADV
bam-5830	116	2	,	,	PUNCT
bam-5830	116	3	in	in	ADP
bam-5830	116	4	pathological	pathological	ADJ
bam-5830	116	5	conditions	condition	NOUN
bam-5830	116	6	,	,	PUNCT
bam-5830	116	7	such	such	ADJ
bam-5830	116	8	as	as	ADP
bam-5830	116	9	muscular	muscular	ADJ
bam-5830	116	10	dystropies	dystropie	NOUN
bam-5830	116	11	,	,	PUNCT
bam-5830	116	12	these	these	DET
bam-5830	116	13	cells	cell	NOUN
bam-5830	116	14	play	play	VERB
bam-5830	116	15	a	a	DET
bam-5830	116	16	negative	negative	ADJ
bam-5830	116	17	role	role	NOUN
bam-5830	116	18	since	since	SCONJ
bam-5830	116	19	they	they	PRON
bam-5830	116	20	are	be	AUX
bam-5830	116	21	responsible	responsible	ADJ
bam-5830	116	22	for	for	ADP
bam-5830	116	23	fibrosis	fibrosis	NOUN
bam-5830	116	24	and	and	CCONJ
bam-5830	116	25	fatty	fatty	ADJ
bam-5830	116	26	tissue	tissue	NOUN
bam-5830	116	27	accumulation	accumulation	NOUN
bam-5830	116	28	.	.	PUNCT
bam-5830	117	1	in	in	ADP
bam-5830	117	2	in	in	ADP
bam-5830	117	3	vitro	vitro	X
bam-5830	117	4	experiments	experiment	NOUN
bam-5830	117	5	we	we	PRON
bam-5830	117	6	have	have	AUX
bam-5830	117	7	observed	observe	VERB
bam-5830	117	8	an	an	DET
bam-5830	117	9	improvement	improvement	NOUN
bam-5830	117	10	in	in	ADP
bam-5830	117	11	the	the	DET
bam-5830	117	12	maturation	maturation	NOUN
bam-5830	117	13	of	of	ADP
bam-5830	117	14	myotubes	myotube	NOUN
bam-5830	117	15	derived	derive	VERB
bam-5830	117	16	from	from	ADP
bam-5830	117	17	satellite	satellite	NOUN
bam-5830	117	18	cells	cell	NOUN
bam-5830	117	19	,	,	PUNCT
bam-5830	117	20	when	when	SCONJ
bam-5830	117	21	co	co	VERB
bam-5830	117	22	-	-	VERB
bam-5830	117	23	cultured	cultured	ADJ
bam-5830	117	24	with	with	ADP
bam-5830	117	25	faps	fap	NOUN
bam-5830	117	26	.	.	PUNCT
bam-5830	118	1	furthermore	furthermore	ADV
bam-5830	118	2	,	,	PUNCT
bam-5830	118	3	we	we	PRON
bam-5830	118	4	have	have	AUX
bam-5830	118	5	also	also	ADV
bam-5830	118	6	observed	observe	VERB
bam-5830	118	7	that	that	SCONJ
bam-5830	118	8	direct	direct	ADJ
bam-5830	118	9	contact	contact	NOUN
bam-5830	118	10	of	of	ADP
bam-5830	118	11	these	these	DET
bam-5830	118	12	two	two	NUM
bam-5830	118	13	cell	cell	NOUN
bam-5830	118	14	populations	population	NOUN
bam-5830	118	15	inhibits	inhibit	VERB
bam-5830	118	16	adipogenic	adipogenic	ADJ
bam-5830	118	17	differentiation	differentiation	NOUN
bam-5830	118	18	of	of	ADP
bam-5830	118	19	faps	fap	NOUN
bam-5830	118	20	while	while	SCONJ
bam-5830	118	21	in	in	ADP
bam-5830	118	22	the	the	DET
bam-5830	118	23	transwell	transwell	NOUN
bam-5830	118	24	system	system	NOUN
bam-5830	118	25	this	this	DET
bam-5830	118	26	inhibition	inhibition	NOUN
bam-5830	118	27	does	do	AUX
bam-5830	118	28	not	not	PART
bam-5830	118	29	occur	occur	VERB
bam-5830	118	30	.	.	PUNCT
bam-5830	119	1	even	even	ADV
bam-5830	119	2	though	though	SCONJ
bam-5830	119	3	there	there	PRON
bam-5830	119	4	is	be	VERB
bam-5830	119	5	a	a	DET
bam-5830	119	6	clear	clear	ADJ
bam-5830	119	7	interaction	interaction	NOUN
bam-5830	119	8	between	between	ADP
bam-5830	119	9	these	these	DET
bam-5830	119	10	two	two	NUM
bam-5830	119	11	populations	population	NOUN
bam-5830	119	12	,	,	PUNCT
bam-5830	119	13	it	it	PRON
bam-5830	119	14	has	have	AUX
bam-5830	119	15	not	not	PART
bam-5830	119	16	been	be	AUX
bam-5830	119	17	thoroughly	thoroughly	ADV
bam-5830	119	18	characterized	characterize	VERB
bam-5830	119	19	yet	yet	ADV
bam-5830	119	20	.	.	PUNCT
bam-5830	120	1	thus	thus	ADV
bam-5830	120	2	exploiting	exploit	VERB
bam-5830	120	3	luminex	luminex	ADJ
bam-5830	120	4	technology	technology	NOUN
bam-5830	120	5	we	we	PRON
bam-5830	120	6	are	be	AUX
bam-5830	120	7	aiming	aim	VERB
bam-5830	120	8	at	at	ADP
bam-5830	120	9	identifying	identify	VERB
bam-5830	120	10	molecules	molecule	NOUN
bam-5830	120	11	affecting	affect	VERB
bam-5830	120	12	the	the	DET
bam-5830	120	13	differentiation	differentiation	NOUN
bam-5830	120	14	process	process	NOUN
bam-5830	120	15	of	of	ADP
bam-5830	120	16	these	these	DET
bam-5830	120	17	two	two	NUM
bam-5830	120	18	cell	cell	NOUN
bam-5830	120	19	types	type	NOUN
bam-5830	120	20	focusing	focus	VERB
bam-5830	120	21	on	on	ADP
bam-5830	120	22	cytokines	cytokine	NOUN
bam-5830	120	23	,	,	PUNCT
bam-5830	120	24	chemokines	chemokine	NOUN
bam-5830	120	25	and	and	CCONJ
bam-5830	120	26	growth	growth	NOUN
bam-5830	120	27	factors	factor	NOUN
bam-5830	120	28	.	.	PUNCT
bam-5830	121	1	in	in	ADP
bam-5830	121	2	addition	addition	NOUN
bam-5830	121	3	we	we	PRON
bam-5830	121	4	are	be	AUX
bam-5830	121	5	planning	plan	VERB
bam-5830	121	6	to	to	PART
bam-5830	121	7	include	include	VERB
bam-5830	121	8	in	in	ADP
bam-5830	121	9	these	these	DET
bam-5830	121	10	studies	study	NOUN
bam-5830	121	11	macrophages	macrophage	NOUN
bam-5830	121	12	and	and	CCONJ
bam-5830	121	13	pericytes	pericyte	NOUN
bam-5830	121	14	in	in	ADP
bam-5830	121	15	order	order	NOUN
bam-5830	121	16	to	to	PART
bam-5830	121	17	obtain	obtain	VERB
bam-5830	121	18	a	a	DET
bam-5830	121	19	more	more	ADV
bam-5830	121	20	complete	complete	ADJ
bam-5830	121	21	picture	picture	NOUN
bam-5830	121	22	of	of	ADP
bam-5830	121	23	molecular	molecular	ADJ
bam-5830	121	24	networks	network	NOUN
bam-5830	121	25	involved	involve	VERB
bam-5830	121	26	in	in	ADP
bam-5830	121	27	myogenesis	myogenesis	NOUN
bam-5830	121	28	and	and	CCONJ
bam-5830	121	29	finally	finally	ADV
bam-5830	121	30	build	build	VERB
bam-5830	121	31	a	a	DET
bam-5830	121	32	cell	cell	NOUN
bam-5830	121	33	-	-	PUNCT
bam-5830	121	34	cell	cell	NOUN
bam-5830	121	35	interaction	interaction	NOUN
bam-5830	121	36	model	model	NOUN
bam-5830	121	37	of	of	ADP
bam-5830	121	38	skeletal	skeletal	ADJ
bam-5830	121	39	muscle	muscle	NOUN
bam-5830	121	40	regeneration	regeneration	NOUN
bam-5830	121	41	.	.	PUNCT
bam-5830	122	1	*	*	PUNCT
bam-5830	122	2	*	*	PUNCT
bam-5830	122	3	*	*	PUNCT
bam-5830	122	4	*	*	PUNCT
bam-5830	122	5	*	*	PUNCT
bam-5830	122	6	extracellular	extracellular	ADJ
bam-5830	122	7	stimulation	stimulation	NOUN
bam-5830	122	8	with	with	ADP
bam-5830	122	9	human	human	ADJ
bam-5830	122	10	“	"	PUNCT
bam-5830	122	11	noisy	noisy	ADJ
bam-5830	122	12	”	"	PUNCT
bam-5830	122	13	electromyographic	electromyographic	ADJ
bam-5830	122	14	patterns	pattern	NOUN
bam-5830	122	15	facilitates	facilitate	VERB
bam-5830	122	16	myotube	myotube	NOUN
bam-5830	122	17	activity	activity	NOUN
bam-5830	122	18	g.	g.	PROPN
bam-5830	122	19	ziraldo1	ziraldo1	PROPN
bam-5830	122	20	,	,	PUNCT
bam-5830	122	21	g.	g.	PROPN
bam-5830	122	22	taccola2,3	taccola2,3	PROPN
bam-5830	122	23	,	,	PUNCT
bam-5830	122	24	t.	t.	PROPN
bam-5830	122	25	coslovich	coslovich	PROPN
bam-5830	122	26	2,3	2,3	NUM
bam-5830	122	27	,	,	PUNCT
bam-5830	122	28	p.	p.	PROPN
bam-5830	122	29	lorenzon1	lorenzon1	PROPN
bam-5830	122	30	,	,	PUNCT
bam-5830	122	31	m.	m.	NOUN
bam-5830	122	32	sciancalepore1	sciancalepore1	PROPN
bam-5830	123	1	1	1	X
bam-5830	123	2	.	.	X
bam-5830	123	3	dept	dept	PROPN
bam-5830	123	4	.	.	PROPN
bam-5830	124	1	life	life	PROPN
bam-5830	124	2	sciences	sciences	PROPN
bam-5830	124	3	&	&	CCONJ
bam-5830	124	4	brain	brain	PROPN
bam-5830	124	5	center	center	PROPN
bam-5830	124	6	,	,	PUNCT
bam-5830	124	7	univ	univ	PROPN
bam-5830	124	8	.	.	PROPN
bam-5830	124	9	,	,	PUNCT
bam-5830	124	10	trieste	trieste	PROPN
bam-5830	124	11	,	,	PUNCT
bam-5830	124	12	italy	italy	PROPN
bam-5830	124	13	;	;	PUNCT
bam-5830	124	14	2	2	X
bam-5830	124	15	.	.	X
bam-5830	124	16	neuroscience	neuroscience	NOUN
bam-5830	124	17	dept	dept	PROPN
bam-5830	124	18	.	.	PROPN
bam-5830	124	19	,	,	PUNCT
bam-5830	124	20	sissa	sissa	PROPN
bam-5830	124	21	,	,	PUNCT
bam-5830	124	22	trieste	trieste	PROPN
bam-5830	124	23	,	,	PUNCT
bam-5830	124	24	italy	italy	PROPN
bam-5830	124	25	;	;	PUNCT
bam-5830	124	26	3	3	X
bam-5830	124	27	.	.	X
bam-5830	124	28	spinal	spinal	ADJ
bam-5830	124	29	lab	lab	NOUN
bam-5830	124	30	.	.	PUNCT
bam-5830	124	31	,	,	PUNCT
bam-5830	124	32	imfr	imfr	NOUN
bam-5830	124	33	,	,	PUNCT
bam-5830	124	34	udine	udine	PROPN
bam-5830	124	35	,	,	PUNCT
bam-5830	124	36	italy	italy	PROPN
bam-5830	124	37	e	e	PROPN
bam-5830	124	38	-	-	NOUN
bam-5830	124	39	mail	mail	NOUN
bam-5830	124	40	:	:	PUNCT
bam-5830	124	41	msciancalepore@units.it	msciancalepore@units.it	NOUN
bam-5830	124	42	electrical	electrical	ADJ
bam-5830	124	43	stimulation	stimulation	NOUN
bam-5830	124	44	(	(	PUNCT
bam-5830	124	45	es	es	NOUN
bam-5830	124	46	)	)	PUNCT
bam-5830	124	47	of	of	ADP
bam-5830	124	48	skeletal	skeletal	ADJ
bam-5830	124	49	muscle	muscle	NOUN
bam-5830	124	50	has	have	AUX
bam-5830	124	51	been	be	AUX
bam-5830	124	52	proposed	propose	VERB
bam-5830	124	53	to	to	PART
bam-5830	124	54	mimic	mimic	VERB
bam-5830	124	55	the	the	DET
bam-5830	124	56	beneficial	beneficial	ADJ
bam-5830	124	57	effects	effect	NOUN
bam-5830	124	58	of	of	ADP
bam-5830	124	59	physical	physical	ADJ
bam-5830	124	60	training	training	NOUN
bam-5830	124	61	and	and	CCONJ
bam-5830	124	62	to	to	PART
bam-5830	124	63	counteract	counteract	VERB
bam-5830	124	64	the	the	DET
bam-5830	124	65	muscle	muscle	NOUN
bam-5830	124	66	atrophy	atrophy	NOUN
bam-5830	124	67	associated	associate	VERB
bam-5830	124	68	with	with	ADP
bam-5830	124	69	reduced	reduce	VERB
bam-5830	124	70	motor	motor	NOUN
bam-5830	124	71	activity	activity	NOUN
bam-5830	124	72	.	.	PUNCT
bam-5830	125	1	if	if	SCONJ
bam-5830	125	2	properly	properly	ADV
bam-5830	125	3	used	use	VERB
bam-5830	125	4	,	,	PUNCT
bam-5830	125	5	it	it	PRON
bam-5830	125	6	can	can	AUX
bam-5830	125	7	be	be	AUX
bam-5830	125	8	a	a	DET
bam-5830	125	9	potent	potent	ADJ
bam-5830	125	10	tool	tool	NOUN
bam-5830	125	11	to	to	PART
bam-5830	125	12	increase	increase	VERB
bam-5830	125	13	strength	strength	NOUN
bam-5830	125	14	and	and	CCONJ
bam-5830	125	15	endurance	endurance	NOUN
bam-5830	125	16	in	in	ADP
bam-5830	125	17	patients	patient	NOUN
bam-5830	125	18	affected	affect	VERB
bam-5830	125	19	by	by	ADP
bam-5830	125	20	muscle	muscle	NOUN
bam-5830	125	21	weakness	weakness	NOUN
bam-5830	125	22	due	due	ADP
bam-5830	125	23	to	to	ADP
bam-5830	125	24	ageing	age	VERB
bam-5830	125	25	or	or	CCONJ
bam-5830	125	26	prolonged	prolonged	ADJ
bam-5830	125	27	debilitating	debilitate	VERB
bam-5830	125	28	illness	illness	NOUN
bam-5830	125	29	.	.	PUNCT
bam-5830	126	1	however	however	ADV
bam-5830	126	2	,	,	PUNCT
bam-5830	126	3	classical	classical	ADJ
bam-5830	126	4	es	es	NOUN
bam-5830	126	5	exhibits	exhibit	VERB
bam-5830	126	6	several	several	ADJ
bam-5830	126	7	limitations	limitation	NOUN
bam-5830	126	8	,	,	PUNCT
bam-5830	126	9	such	such	ADJ
bam-5830	126	10	as	as	ADP
bam-5830	126	11	the	the	DET
bam-5830	126	12	unpleasant	unpleasant	ADJ
bam-5830	126	13	symptoms	symptom	NOUN
bam-5830	126	14	due	due	ADJ
bam-5830	126	15	to	to	ADP
bam-5830	126	16	pulse	pulse	NOUN
bam-5830	126	17	strength	strength	NOUN
bam-5830	126	18	and	and	CCONJ
bam-5830	126	19	the	the	DET
bam-5830	126	20	occurrence	occurrence	NOUN
bam-5830	126	21	of	of	ADP
bam-5830	126	22	muscle	muscle	NOUN
bam-5830	126	23	fatigue	fatigue	NOUN
bam-5830	126	24	.	.	PUNCT
bam-5830	127	1	the	the	DET
bam-5830	127	2	most	most	ADV
bam-5830	127	3	appropriate	appropriate	ADJ
bam-5830	127	4	parameters	parameter	NOUN
bam-5830	127	5	of	of	ADP
bam-5830	127	6	stimulation	stimulation	NOUN
bam-5830	127	7	,	,	PUNCT
bam-5830	127	8	such	such	ADJ
bam-5830	127	9	as	as	ADP
bam-5830	127	10	intensity	intensity	NOUN
bam-5830	127	11	,	,	PUNCT
bam-5830	127	12	frequency	frequency	NOUN
bam-5830	127	13	and	and	CCONJ
bam-5830	127	14	pulse	pulse	NOUN
bam-5830	127	15	duration	duration	NOUN
bam-5830	127	16	,	,	PUNCT
bam-5830	127	17	are	be	AUX
bam-5830	127	18	still	still	ADV
bam-5830	127	19	under	under	ADP
bam-5830	127	20	debate	debate	NOUN
bam-5830	127	21	.	.	PUNCT
bam-5830	128	1	field	field	NOUN
bam-5830	128	2	ess	ess	PROPN
bam-5830	128	3	were	be	AUX
bam-5830	128	4	given	give	VERB
bam-5830	128	5	to	to	PART
bam-5830	128	6	mouse	mouse	VERB
bam-5830	128	7	skeletal	skeletal	ADJ
bam-5830	128	8	myotubes	myotube	NOUN
bam-5830	128	9	in	in	ADP
bam-5830	128	10	culture	culture	NOUN
bam-5830	128	11	.	.	PUNCT
bam-5830	129	1	changes	change	NOUN
bam-5830	129	2	in	in	ADP
bam-5830	129	3	membrane	membrane	NOUN
bam-5830	129	4	potential	potential	NOUN
bam-5830	129	5	were	be	AUX
bam-5830	129	6	detected	detect	VERB
bam-5830	129	7	by	by	ADP
bam-5830	129	8	perforated	perforate	VERB
bam-5830	129	9	patch	patch	ADJ
bam-5830	129	10	recordings	recording	NOUN
bam-5830	129	11	and	and	CCONJ
bam-5830	129	12	calcium	calcium	NOUN
bam-5830	129	13	dynamics	dynamic	NOUN
bam-5830	129	14	was	be	AUX
bam-5830	129	15	followed	follow	VERB
bam-5830	129	16	using	use	VERB
bam-5830	129	17	fluorescent	fluorescent	ADJ
bam-5830	129	18	indicators	indicator	NOUN
bam-5830	129	19	.	.	PUNCT
bam-5830	130	1	different	different	ADJ
bam-5830	130	2	patterns	pattern	NOUN
bam-5830	130	3	of	of	ADP
bam-5830	130	4	es	es	NOUN
bam-5830	130	5	were	be	AUX
bam-5830	130	6	tested	test	VERB
bam-5830	130	7	.	.	PUNCT
bam-5830	131	1	tetanic	tetanic	ADJ
bam-5830	131	2	high	high	ADJ
bam-5830	131	3	frequency	frequency	NOUN
bam-5830	131	4	stimulation	stimulation	NOUN
bam-5830	131	5	at	at	ADP
bam-5830	131	6	45	45	NUM
bam-5830	131	7	hz	hz	PRON
bam-5830	131	8	induced	induced	ADJ
bam-5830	131	9	voltage	voltage	NOUN
bam-5830	131	10	changes	change	NOUN
bam-5830	131	11	invariably	invariably	ADV
bam-5830	131	12	characterized	characterize	VERB
bam-5830	131	13	by	by	ADP
bam-5830	131	14	failures	failure	NOUN
bam-5830	131	15	,	,	PUNCT
bam-5830	131	16	and	and	CCONJ
bam-5830	131	17	discontinuous	discontinuous	ADJ
bam-5830	131	18	firing	firing	NOUN
bam-5830	131	19	preceding	precede	VERB
bam-5830	131	20	the	the	DET
bam-5830	131	21	complete	complete	ADJ
bam-5830	131	22	disappearance	disappearance	NOUN
bam-5830	131	23	of	of	ADP
bam-5830	131	24	the	the	DET
bam-5830	131	25	electrical	electrical	ADJ
bam-5830	131	26	activity	activity	NOUN
bam-5830	131	27	,	,	PUNCT
bam-5830	131	28	whereas	whereas	SCONJ
bam-5830	131	29	low	low	ADJ
bam-5830	131	30	-	-	PUNCT
bam-5830	131	31	frequency	frequency	NOUN
bam-5830	131	32	stimulations	stimulation	NOUN
bam-5830	131	33	at	at	ADP
bam-5830	131	34	1	1	NUM
bam-5830	131	35	hz	hz	VERB
bam-5830	131	36	more	more	ADV
bam-5830	131	37	efficiently	efficiently	ADV
bam-5830	131	38	elicited	elicited	ADJ
bam-5830	131	39	single	single	ADJ
bam-5830	131	40	action	action	NOUN
bam-5830	131	41	potentials	potential	VERB
bam-5830	131	42	.	.	PUNCT
bam-5830	132	1	an	an	DET
bam-5830	132	2	innovative	innovative	ADJ
bam-5830	132	3	“	"	PUNCT
bam-5830	132	4	noisy	noisy	ADJ
bam-5830	132	5	”	"	PUNCT
bam-5830	132	6	waveform	waveform	NOUN
bam-5830	132	7	es	es	NOUN
bam-5830	132	8	pattern	pattern	NOUN
bam-5830	132	9	was	be	AUX
bam-5830	132	10	tested	test	VERB
bam-5830	132	11	,	,	PUNCT
bam-5830	132	12	obtained	obtain	VERB
bam-5830	132	13	from	from	ADP
bam-5830	132	14	a	a	DET
bam-5830	132	15	segment	segment	NOUN
bam-5830	132	16	of	of	ADP
bam-5830	132	17	electromyogram	electromyogram	NOUN
bam-5830	132	18	recording	recording	NOUN
bam-5830	132	19	,	,	PUNCT
bam-5830	132	20	sampled	sample	VERB
bam-5830	132	21	from	from	ADP
bam-5830	132	22	a	a	DET
bam-5830	132	23	limb	limb	NOUN
bam-5830	132	24	muscle	muscle	NOUN
bam-5830	132	25	of	of	ADP
bam-5830	132	26	adult	adult	NOUN
bam-5830	132	27	volunteers	volunteer	NOUN
bam-5830	132	28	during	during	ADP
bam-5830	132	29	the	the	DET
bam-5830	132	30	execution	execution	NOUN
bam-5830	132	31	of	of	ADP
bam-5830	132	32	a	a	DET
bam-5830	132	33	rhythmic	rhythmic	ADJ
bam-5830	132	34	motor	motor	NOUN
bam-5830	132	35	activity	activity	NOUN
bam-5830	132	36	.	.	PUNCT
bam-5830	133	1	using	use	VERB
bam-5830	133	2	half	half	NOUN
bam-5830	133	3	of	of	ADP
bam-5830	133	4	the	the	DET
bam-5830	133	5	intensity	intensity	NOUN
bam-5830	133	6	of	of	ADP
bam-5830	133	7	stimulation	stimulation	NOUN
bam-5830	133	8	employed	employ	VERB
bam-5830	133	9	for	for	ADP
bam-5830	133	10	more	more	ADV
bam-5830	133	11	stereotyped	stereotype	VERB
bam-5830	133	12	es	es	NOUN
bam-5830	133	13	patterns	pattern	NOUN
bam-5830	133	14	,	,	PUNCT
bam-5830	133	15	it	it	PRON
bam-5830	133	16	was	be	AUX
bam-5830	133	17	found	find	VERB
bam-5830	133	18	to	to	PART
bam-5830	133	19	be	be	AUX
bam-5830	133	20	more	more	ADV
bam-5830	133	21	efficient	efficient	ADJ
bam-5830	133	22	in	in	ADP
bam-5830	133	23	inducing	induce	VERB
bam-5830	133	24	repetitive	repetitive	ADJ
bam-5830	133	25	cell	cell	NOUN
bam-5830	133	26	firing	firing	NOUN
bam-5830	133	27	,	,	PUNCT
bam-5830	133	28	calcium	calcium	NOUN
bam-5830	133	29	transients	transient	NOUN
bam-5830	133	30	and	and	CCONJ
bam-5830	133	31	cell	cell	NOUN
bam-5830	133	32	twitching	twitching	NOUN
bam-5830	133	33	.	.	PUNCT
bam-5830	134	1	we	we	PRON
bam-5830	134	2	suggest	suggest	VERB
bam-5830	134	3	this	this	DET
bam-5830	134	4	approach	approach	NOUN
bam-5830	134	5	as	as	ADP
bam-5830	134	6	a	a	DET
bam-5830	134	7	new	new	ADJ
bam-5830	134	8	strategy	strategy	NOUN
bam-5830	134	9	for	for	ADP
bam-5830	134	10	the	the	DET
bam-5830	134	11	design	design	NOUN
bam-5830	134	12	of	of	ADP
bam-5830	134	13	new	new	ADJ
bam-5830	134	14	electrical	electrical	ADJ
bam-5830	134	15	devices	device	NOUN
bam-5830	134	16	able	able	ADJ
bam-5830	134	17	to	to	PART
bam-5830	134	18	provide	provide	VERB
bam-5830	134	19	a	a	DET
bam-5830	134	20	therapy	therapy	NOUN
bam-5830	134	21	option	option	NOUN
bam-5830	134	22	for	for	ADP
bam-5830	134	23	injured	injure	VERB
bam-5830	134	24	muscles	muscle	NOUN
bam-5830	134	25	in	in	ADP
bam-5830	134	26	human	human	ADJ
bam-5830	134	27	patients	patient	NOUN
bam-5830	134	28	.	.	PUNCT
bam-5830	135	1	*	*	PUNCT
bam-5830	135	2	*	*	PUNCT
bam-5830	135	3	*	*	PUNCT
bam-5830	135	4	*	*	PUNCT
bam-5830	135	5	*	*	PUNCT
bam-5830	135	6	*	*	PUNCT
bam-5830	135	7	*	*	PUNCT
bam-5830	135	8	*	*	PUNCT
bam-5830	135	9	*	*	PUNCT
bam-5830	135	10	*	*	PUNCT
bam-5830	135	11	*	*	PUNCT
bam-5830	135	12	*	*	PUNCT
bam-5830	135	13	*	*	PUNCT
bam-5830	135	14	*	*	PUNCT
bam-5830	135	15	*	*	PUNCT
bam-5830	135	16	session	session	NOUN
bam-5830	135	17	2	2	NUM
bam-5830	135	18	.	.	PUNCT
bam-5830	135	19	biophysics	biophysic	NOUN
bam-5830	135	20	and	and	CCONJ
bam-5830	135	21	e	e	NOUN
bam-5830	135	22	-	-	PROPN
bam-5830	135	23	c	c	ADJ
bam-5830	135	24	coupling	coupling	NOUN
bam-5830	135	25	in	in	ADP
bam-5830	135	26	the	the	DET
bam-5830	135	27	physiopathology	physiopathology	NOUN
bam-5830	135	28	of	of	ADP
bam-5830	135	29	neuromuscular	neuromuscular	ADJ
bam-5830	135	30	diseases	disease	NOUN
bam-5830	135	31	oscillatory	oscillatory	ADJ
bam-5830	135	32	behaviour	behaviour	NOUN
bam-5830	135	33	in	in	ADP
bam-5830	135	34	muscle	muscle	NOUN
bam-5830	135	35	myosin	myosin	PROPN
bam-5830	135	36	l.	l.	PROPN
bam-5830	135	37	marcucci	marcucci	PROPN
bam-5830	135	38	1,2	1,2	NUM
bam-5830	135	39	,	,	PUNCT
bam-5830	135	40	t.	t.	PROPN
bam-5830	135	41	washio	washio	NOUN
bam-5830	135	42	3	3	NUM
bam-5830	135	43	,	,	PUNCT
bam-5830	135	44	t.	t.	NOUN
bam-5830	135	45	yanagida	yanagida	PROPN
bam-5830	135	46	2	2	NUM
bam-5830	135	47	1	1	X
bam-5830	135	48	.	.	PUNCT
bam-5830	136	1	department	department	NOUN
bam-5830	136	2	of	of	ADP
bam-5830	136	3	biomedical	biomedical	ADJ
bam-5830	136	4	sciences	sciences	PROPN
bam-5830	136	5	,	,	PUNCT
bam-5830	136	6	university	university	NOUN
bam-5830	136	7	of	of	ADP
bam-5830	136	8	padova	padova	PROPN
bam-5830	136	9	,	,	PUNCT
bam-5830	136	10	padova	padova	PROPN
bam-5830	136	11	,	,	PUNCT
bam-5830	136	12	italy	italy	PROPN
bam-5830	136	13	;	;	PUNCT
bam-5830	136	14	2	2	X
bam-5830	136	15	.	.	NOUN
bam-5830	136	16	quantitative	quantitative	ADJ
bam-5830	136	17	biology	biology	NOUN
bam-5830	136	18	center	center	NOUN
bam-5830	136	19	,	,	PUNCT
bam-5830	136	20	riken	riken	PROPN
bam-5830	136	21	japan	japan	PROPN
bam-5830	136	22	;	;	PUNCT
bam-5830	136	23	3	3	X
bam-5830	136	24	.	.	X
bam-5830	136	25	graduate	graduate	NOUN
bam-5830	136	26	school	school	PROPN
bam-5830	136	27	of	of	ADP
bam-5830	136	28	frontier	frontier	NOUN
bam-5830	136	29	sciences	sciences	PROPN
bam-5830	136	30	,	,	PUNCT
bam-5830	136	31	university	university	NOUN
bam-5830	136	32	of	of	ADP
bam-5830	136	33	tokyo	tokyo	PROPN
bam-5830	136	34	,	,	PUNCT
bam-5830	136	35	japan	japan	PROPN
bam-5830	136	36	.	.	PUNCT
bam-5830	137	1	e	e	X
bam-5830	137	2	-	-	NOUN
bam-5830	137	3	mail	mail	NOUN
bam-5830	137	4	:	:	PUNCT
bam-5830	137	5	lorenzo.marcucci@unipd.it	lorenzo.marcucci@unipd.it	PROPN
bam-5830	137	6	muscle	muscle	NOUN
bam-5830	137	7	contraction	contraction	NOUN
bam-5830	137	8	is	be	AUX
bam-5830	137	9	generated	generate	VERB
bam-5830	137	10	by	by	ADP
bam-5830	137	11	cyclical	cyclical	ADJ
bam-5830	137	12	interactions	interaction	NOUN
bam-5830	137	13	of	of	ADP
bam-5830	137	14	myosin	myosin	NOUN
bam-5830	137	15	heads	head	NOUN
bam-5830	137	16	with	with	ADP
bam-5830	137	17	actin	actin	NOUN
bam-5830	137	18	filaments	filament	NOUN
bam-5830	137	19	to	to	PART
bam-5830	137	20	form	form	VERB
bam-5830	137	21	the	the	DET
bam-5830	137	22	actomyosin	actomyosin	NOUN
bam-5830	137	23	complex	complex	NOUN
bam-5830	137	24	.	.	PUNCT
bam-5830	138	1	the	the	DET
bam-5830	138	2	stable	stable	ADJ
bam-5830	138	3	configurations	configuration	NOUN
bam-5830	138	4	of	of	ADP
bam-5830	138	5	the	the	DET
bam-5830	138	6	actomyosin	actomyosin	NOUN
bam-5830	138	7	complex	complex	NOUN
bam-5830	138	8	have	have	AUX
bam-5830	138	9	been	be	AUX
bam-5830	138	10	described	describe	VERB
bam-5830	138	11	in	in	ADP
bam-5830	138	12	detail	detail	NOUN
bam-5830	138	13	,	,	PUNCT
bam-5830	138	14	but	but	CCONJ
bam-5830	138	15	whether	whether	SCONJ
bam-5830	138	16	in	in	ADP
bam-5830	138	17	vivo	vivo	NOUN
bam-5830	138	18	,	,	PUNCT
bam-5830	138	19	at	at	ADP
bam-5830	138	20	physiological	physiological	ADJ
bam-5830	138	21	temperatures	temperature	NOUN
bam-5830	138	22	,	,	PUNCT
bam-5830	138	23	these	these	DET
bam-5830	138	24	configurations	configuration	NOUN
bam-5830	138	25	are	be	AUX
bam-5830	138	26	fixed	fix	VERB
bam-5830	138	27	to	to	ADP
bam-5830	138	28	the	the	DET
bam-5830	138	29	ones	one	NOUN
bam-5830	138	30	observed	observe	VERB
bam-5830	138	31	in	in	ADP
bam-5830	138	32	cryomicroscopy	cryomicroscopy	NOUN
bam-5830	138	33	(	(	PUNCT
bam-5830	138	34	at	at	ADP
bam-5830	138	35	low	low	ADJ
bam-5830	138	36	temperature	temperature	NOUN
bam-5830	138	37	)	)	PUNCT
bam-5830	138	38	or	or	CCONJ
bam-5830	138	39	undergo	undergo	VERB
bam-5830	138	40	thermal	thermal	ADJ
bam-5830	138	41	oscillations	oscillation	NOUN
bam-5830	138	42	is	be	AUX
bam-5830	138	43	unknown	unknown	ADJ
bam-5830	138	44	and	and	CCONJ
bam-5830	138	45	not	not	PART
bam-5830	138	46	generally	generally	ADV
bam-5830	138	47	considered	consider	VERB
bam-5830	138	48	in	in	ADP
bam-5830	138	49	mathematical	mathematical	ADJ
bam-5830	138	50	modeling	modeling	NOUN
bam-5830	138	51	.	.	PUNCT
bam-5830	139	1	by	by	ADP
bam-5830	139	2	comparing	compare	VERB
bam-5830	139	3	three	three	NUM
bam-5830	139	4	abstracts	abstract	NOUN
bam-5830	139	5	of	of	ADP
bam-5830	139	6	the	the	DET
bam-5830	139	7	xii	xii	PROPN
bam-5830	139	8	iim	iim	NOUN
bam-5830	139	9	myology	myology	NOUN
bam-5830	139	10	meeting	meeting	NOUN
bam-5830	139	11	october	october	PROPN
bam-5830	139	12	1–4	1–4	PROPN
bam-5830	139	13	,	,	PUNCT
bam-5830	139	14	2015	2015	NUM
bam-5830	139	15	eur	eur	PROPN
bam-5830	139	16	j	j	PROPN
bam-5830	139	17	transl	transl	PROPN
bam-5830	139	18	myol	myol	PROPN
bam-5830	139	19	basic	basic	ADJ
bam-5830	139	20	appl	appl	NOUN
bam-5830	139	21	myol	myol	NOUN
bam-5830	139	22	2016	2016	NUM
bam-5830	139	23	;	;	PUNCT
bam-5830	139	24	26	26	NUM
bam-5830	139	25	(	(	PUNCT
bam-5830	139	26	1):2	1):2	NUM
bam-5830	139	27	-	-	SYM
bam-5830	139	28	24	24	NUM
bam-5830	139	29	this	this	DET
bam-5830	139	30	article	article	NOUN
bam-5830	139	31	is	be	AUX
bam-5830	139	32	distributed	distribute	VERB
bam-5830	139	33	under	under	ADP
bam-5830	139	34	the	the	DET
bam-5830	139	35	terms	term	NOUN
bam-5830	139	36	of	of	ADP
bam-5830	139	37	the	the	DET
bam-5830	139	38	creative	creative	ADJ
bam-5830	139	39	commons	common	NOUN
bam-5830	139	40	attribution	attribution	NOUN
bam-5830	139	41	noncommercial	noncommercial	ADJ
bam-5830	139	42	license	license	NOUN
bam-5830	139	43	(	(	PUNCT
bam-5830	139	44	cc	cc	NOUN
bam-5830	139	45	by	by	ADP
bam-5830	139	46	-	-	PUNCT
bam-5830	139	47	nc	nc	PROPN
bam-5830	139	48	4.0	4.0	NUM
bam-5830	139	49	)	)	PUNCT
bam-5830	139	50	which	which	PRON
bam-5830	139	51	permits	permit	VERB
bam-5830	139	52	any	any	DET
bam-5830	139	53	noncommercial	noncommercial	ADJ
bam-5830	139	54	use	use	NOUN
bam-5830	139	55	,	,	PUNCT
bam-5830	139	56	distribution	distribution	NOUN
bam-5830	139	57	,	,	PUNCT
bam-5830	139	58	and	and	CCONJ
bam-5830	139	59	reproduction	reproduction	NOUN
bam-5830	139	60	in	in	ADP
bam-5830	139	61	any	any	DET
bam-5830	139	62	medium	medium	NOUN
bam-5830	139	63	,	,	PUNCT
bam-5830	139	64	provided	provide	VERB
bam-5830	139	65	the	the	DET
bam-5830	139	66	original	original	ADJ
bam-5830	139	67	author(s	author(s	NOUN
bam-5830	139	68	)	)	PUNCT
bam-5830	139	69	and	and	CCONJ
bam-5830	139	70	source	source	NOUN
bam-5830	139	71	are	be	AUX
bam-5830	139	72	credited	credit	VERB
bam-5830	139	73	.	.	PUNCT
bam-5830	140	1	7	7	NUM
bam-5830	140	2	mathematical	mathematical	ADJ
bam-5830	140	3	models	model	NOUN
bam-5830	140	4	,	,	PUNCT
bam-5830	140	5	we	we	PRON
bam-5830	140	6	analyze	analyze	VERB
bam-5830	140	7	how	how	SCONJ
bam-5830	140	8	this	this	DET
bam-5830	140	9	intrinsic	intrinsic	ADJ
bam-5830	140	10	property	property	NOUN
bam-5830	140	11	of	of	ADP
bam-5830	140	12	the	the	DET
bam-5830	140	13	actomyosin	actomyosin	NOUN
bam-5830	140	14	complex	complex	NOUN
bam-5830	140	15	affects	affect	VERB
bam-5830	140	16	muscle	muscle	NOUN
bam-5830	140	17	contraction	contraction	NOUN
bam-5830	140	18	at	at	ADP
bam-5830	140	19	three	three	NUM
bam-5830	140	20	level	level	NOUN
bam-5830	140	21	;	;	PUNCT
bam-5830	140	22	namely	namely	ADV
bam-5830	140	23	,	,	PUNCT
bam-5830	140	24	single	single	ADJ
bam-5830	140	25	cross	cross	NOUN
bam-5830	140	26	-	-	NOUN
bam-5830	140	27	bridge	bridge	ADJ
bam-5830	140	28	,	,	PUNCT
bam-5830	140	29	single	single	ADJ
bam-5830	140	30	fiber	fiber	NOUN
bam-5830	140	31	and	and	CCONJ
bam-5830	140	32	organ	organ	NOUN
bam-5830	140	33	levels	level	NOUN
bam-5830	140	34	,	,	PUNCT
bam-5830	140	35	in	in	ADP
bam-5830	140	36	a	a	DET
bam-5830	140	37	ceteris	ceteris	NOUN
bam-5830	140	38	paribus	paribus	ADJ
bam-5830	140	39	analysis	analysis	NOUN
bam-5830	140	40	.	.	PUNCT
bam-5830	141	1	we	we	PRON
bam-5830	141	2	observed	observe	VERB
bam-5830	141	3	that	that	SCONJ
bam-5830	141	4	state	state	NOUN
bam-5830	141	5	fluctuations	fluctuation	NOUN
bam-5830	141	6	allow	allow	VERB
bam-5830	141	7	the	the	DET
bam-5830	141	8	lever	lever	NOUN
bam-5830	141	9	arm	arm	NOUN
bam-5830	141	10	of	of	ADP
bam-5830	141	11	myosin	myosin	NOUN
bam-5830	141	12	to	to	PART
bam-5830	141	13	easily	easily	ADV
bam-5830	141	14	and	and	CCONJ
bam-5830	141	15	dynamically	dynamically	ADV
bam-5830	141	16	explore	explore	VERB
bam-5830	141	17	all	all	DET
bam-5830	141	18	possible	possible	ADJ
bam-5830	141	19	minima	minima	NOUN
bam-5830	141	20	in	in	ADP
bam-5830	141	21	the	the	DET
bam-5830	141	22	energy	energy	NOUN
bam-5830	141	23	landscape	landscape	NOUN
bam-5830	141	24	,	,	PUNCT
bam-5830	141	25	generating	generate	VERB
bam-5830	141	26	several	several	ADJ
bam-5830	141	27	backward	backward	ADJ
bam-5830	141	28	and	and	CCONJ
bam-5830	141	29	forward	forward	ADV
bam-5830	141	30	jumps	jump	VERB
bam-5830	141	31	between	between	ADP
bam-5830	141	32	states	state	NOUN
bam-5830	141	33	during	during	ADP
bam-5830	141	34	the	the	DET
bam-5830	141	35	lifetime	lifetime	NOUN
bam-5830	141	36	of	of	ADP
bam-5830	141	37	the	the	DET
bam-5830	141	38	actomyosin	actomyosin	NOUN
bam-5830	141	39	complex	complex	NOUN
bam-5830	141	40	,	,	PUNCT
bam-5830	141	41	whereas	whereas	SCONJ
bam-5830	141	42	the	the	DET
bam-5830	141	43	rigid	rigid	ADJ
bam-5830	141	44	case	case	NOUN
bam-5830	141	45	is	be	AUX
bam-5830	141	46	characterized	characterize	VERB
bam-5830	141	47	by	by	ADP
bam-5830	141	48	fewer	few	ADJ
bam-5830	141	49	force	force	NOUN
bam-5830	141	50	generating	generate	VERB
bam-5830	141	51	events	event	NOUN
bam-5830	141	52	.	.	PUNCT
bam-5830	142	1	therefore	therefore	ADV
bam-5830	142	2	,	,	PUNCT
bam-5830	142	3	dynamical	dynamical	ADJ
bam-5830	142	4	oscillations	oscillation	NOUN
bam-5830	142	5	enable	enable	VERB
bam-5830	142	6	an	an	DET
bam-5830	142	7	efficient	efficient	ADJ
bam-5830	142	8	contraction	contraction	NOUN
bam-5830	142	9	mechanism	mechanism	NOUN
bam-5830	142	10	,	,	PUNCT
bam-5830	142	11	in	in	ADP
bam-5830	142	12	which	which	PRON
bam-5830	142	13	a	a	DET
bam-5830	142	14	higher	high	ADJ
bam-5830	142	15	force	force	NOUN
bam-5830	142	16	is	be	AUX
bam-5830	142	17	sustained	sustain	VERB
bam-5830	142	18	by	by	ADP
bam-5830	142	19	fewer	few	ADJ
bam-5830	142	20	attached	attached	ADJ
bam-5830	142	21	cross	cross	NOUN
bam-5830	142	22	-	-	NOUN
bam-5830	142	23	bridges	bridge	NOUN
bam-5830	142	24	.	.	PUNCT
bam-5830	143	1	*	*	PUNCT
bam-5830	143	2	*	*	PUNCT
bam-5830	143	3	*	*	PUNCT
bam-5830	143	4	*	*	PUNCT
bam-5830	143	5	*	*	PUNCT
bam-5830	143	6	the	the	DET
bam-5830	143	7	molecular	molecular	ADJ
bam-5830	143	8	machinery	machinery	NOUN
bam-5830	143	9	for	for	ADP
bam-5830	143	10	pretzel	pretzel	ADJ
bam-5830	143	11	formation	formation	NOUN
bam-5830	143	12	at	at	ADP
bam-5830	143	13	the	the	DET
bam-5830	143	14	neuromuscular	neuromuscular	ADJ
bam-5830	143	15	junction	junction	NOUN
bam-5830	143	16	p.	p.	NOUN
bam-5830	143	17	niewiadomski	niewiadomski	NOUN
bam-5830	143	18	1	1	NUM
bam-5830	143	19	,	,	PUNCT
bam-5830	143	20	m.	m.	NOUN
bam-5830	143	21	gawor	gawor	NOUN
bam-5830	143	22	1	1	NUM
bam-5830	143	23	,	,	PUNCT
bam-5830	143	24	k.	k.	PROPN
bam-5830	143	25	bernadzki	bernadzki	VERB
bam-5830	143	26	1	1	NUM
bam-5830	143	27	,	,	PUNCT
bam-5830	143	28	j.	j.	PROPN
bam-5830	143	29	jóźwiak	jóźwiak	PROPN
bam-5830	143	30	2	2	NUM
bam-5830	143	31	,	,	PUNCT
bam-5830	143	32	k.	k.	PROPN
bam-5830	143	33	rojek	rojek	PROPN
bam-5830	143	34	1	1	NUM
bam-5830	143	35	,	,	PUNCT
bam-5830	143	36	m.	m.	NOUN
bam-5830	143	37	jolanta	jolanta	PROPN
bam-5830	143	38	rędowicz	rędowicz	PROPN
bam-5830	143	39	2	2	NUM
bam-5830	143	40	,	,	PUNCT
bam-5830	143	41	t.	t.	NOUN
bam-5830	143	42	prószyński	prószyński	NOUN
bam-5830	143	43	1	1	NUM
bam-5830	143	44	1	1	NUM
bam-5830	143	45	.	.	PUNCT
bam-5830	143	46	laboratory	laboratory	NOUN
bam-5830	143	47	of	of	ADP
bam-5830	143	48	synaptogenesis	synaptogenesis	NOUN
bam-5830	143	49	,	,	PUNCT
bam-5830	143	50	department	department	NOUN
bam-5830	143	51	of	of	ADP
bam-5830	143	52	cell	cell	NOUN
bam-5830	143	53	biology	biology	NOUN
bam-5830	143	54	,	,	PUNCT
bam-5830	143	55	nencki	nencki	PROPN
bam-5830	143	56	institute	institute	PROPN
bam-5830	143	57	of	of	ADP
bam-5830	143	58	experimental	experimental	ADJ
bam-5830	143	59	biology	biology	NOUN
bam-5830	143	60	,	,	PUNCT
bam-5830	143	61	warsaw	warsaw	PROPN
bam-5830	143	62	,	,	PUNCT
bam-5830	143	63	poland	poland	PROPN
bam-5830	143	64	;	;	PUNCT
bam-5830	143	65	2	2	X
bam-5830	143	66	.	.	X
bam-5830	143	67	laboratory	laboratory	NOUN
bam-5830	143	68	of	of	ADP
bam-5830	143	69	cell	cell	NOUN
bam-5830	143	70	motility	motility	NOUN
bam-5830	143	71	,	,	PUNCT
bam-5830	143	72	department	department	NOUN
bam-5830	143	73	of	of	ADP
bam-5830	143	74	biochemistry	biochemistry	NOUN
bam-5830	143	75	,	,	PUNCT
bam-5830	143	76	nencki	nencki	PROPN
bam-5830	143	77	institute	institute	PROPN
bam-5830	143	78	of	of	ADP
bam-5830	143	79	experimental	experimental	ADJ
bam-5830	143	80	biology	biology	NOUN
bam-5830	143	81	,	,	PUNCT
bam-5830	143	82	warsaw	warsaw	PROPN
bam-5830	143	83	,	,	PUNCT
bam-5830	143	84	poland	poland	PROPN
bam-5830	143	85	e	e	PROPN
bam-5830	143	86	-	-	NOUN
bam-5830	143	87	mail	mail	NOUN
bam-5830	143	88	:	:	PUNCT
bam-5830	144	1	t.proszynski@nencki.gov.pl	t.proszynski@nencki.gov.pl	PROPN
bam-5830	144	2	mammalian	mammalian	ADJ
bam-5830	144	3	neuromuscular	neuromuscular	ADJ
bam-5830	144	4	junctions	junction	NOUN
bam-5830	144	5	(	(	PUNCT
bam-5830	144	6	nmjs	nmj	NOUN
bam-5830	144	7	)	)	PUNCT
bam-5830	144	8	undergo	undergo	VERB
bam-5830	144	9	a	a	DET
bam-5830	144	10	postnatal	postnatal	ADJ
bam-5830	144	11	topological	topological	ADJ
bam-5830	144	12	transformation	transformation	NOUN
bam-5830	144	13	from	from	ADP
bam-5830	144	14	a	a	DET
bam-5830	144	15	simple	simple	ADJ
bam-5830	144	16	oval	oval	NOUN
bam-5830	144	17	plaque	plaque	NOUN
bam-5830	144	18	to	to	ADP
bam-5830	144	19	a	a	DET
bam-5830	144	20	complex	complex	ADJ
bam-5830	144	21	branch	branch	NOUN
bam-5830	144	22	-	-	PUNCT
bam-5830	144	23	shaped	shape	VERB
bam-5830	144	24	structure	structure	NOUN
bam-5830	144	25	often	often	ADV
bam-5830	144	26	called	call	VERB
bam-5830	144	27	a	a	DET
bam-5830	144	28	“	"	PUNCT
bam-5830	144	29	pretzel	pretzel	NOUN
bam-5830	144	30	”	"	PUNCT
bam-5830	144	31	.	.	PUNCT
bam-5830	145	1	although	although	SCONJ
bam-5830	145	2	abnormalities	abnormality	NOUN
bam-5830	145	3	in	in	ADP
bam-5830	145	4	nmj	nmj	NOUN
bam-5830	145	5	maturation	maturation	NOUN
bam-5830	145	6	and/or	and/or	CCONJ
bam-5830	145	7	maintenance	maintenance	NOUN
bam-5830	145	8	are	be	AUX
bam-5830	145	9	frequently	frequently	ADV
bam-5830	145	10	observed	observe	VERB
bam-5830	145	11	in	in	ADP
bam-5830	145	12	neuromuscular	neuromuscular	ADJ
bam-5830	145	13	disorders	disorder	NOUN
bam-5830	145	14	,	,	PUNCT
bam-5830	145	15	such	such	ADJ
bam-5830	145	16	as	as	ADP
bam-5830	145	17	congenital	congenital	ADJ
bam-5830	145	18	myasthenic	myasthenic	ADJ
bam-5830	145	19	syndromes	syndrome	NOUN
bam-5830	145	20	(	(	PUNCT
bam-5830	145	21	cmss	cmss	NOUN
bam-5830	145	22	)	)	PUNCT
bam-5830	145	23	,	,	PUNCT
bam-5830	145	24	the	the	DET
bam-5830	145	25	mechanisms	mechanism	NOUN
bam-5830	145	26	that	that	PRON
bam-5830	145	27	govern	govern	VERB
bam-5830	145	28	synaptic	synaptic	ADJ
bam-5830	145	29	developmental	developmental	ADJ
bam-5830	145	30	remodeling	remodeling	NOUN
bam-5830	145	31	are	be	AUX
bam-5830	145	32	poorly	poorly	ADV
bam-5830	145	33	understood	understand	VERB
bam-5830	145	34	.	.	PUNCT
bam-5830	146	1	it	it	PRON
bam-5830	146	2	was	be	AUX
bam-5830	146	3	reported	report	VERB
bam-5830	146	4	that	that	SCONJ
bam-5830	146	5	myotubes	myotube	NOUN
bam-5830	146	6	,	,	PUNCT
bam-5830	146	7	when	when	SCONJ
bam-5830	146	8	cultured	cultured	ADJ
bam-5830	146	9	aneurally	aneurally	ADV
bam-5830	146	10	on	on	ADP
bam-5830	146	11	laminin	laminin	NOUN
bam-5830	146	12	-	-	PUNCT
bam-5830	146	13	coated	coat	VERB
bam-5830	146	14	surfaces	surface	NOUN
bam-5830	146	15	,	,	PUNCT
bam-5830	146	16	form	form	NOUN
bam-5830	146	17	complex	complex	ADJ
bam-5830	146	18	postsynaptic	postsynaptic	ADJ
bam-5830	146	19	machinery	machinery	NOUN
bam-5830	146	20	,	,	PUNCT
bam-5830	146	21	which	which	PRON
bam-5830	146	22	resembles	resemble	VERB
bam-5830	146	23	that	that	SCONJ
bam-5830	146	24	at	at	ADP
bam-5830	146	25	the	the	DET
bam-5830	146	26	nmj	nmj	NOUN
bam-5830	146	27	.	.	PUNCT
bam-5830	147	1	interestingly	interestingly	ADV
bam-5830	147	2	,	,	PUNCT
bam-5830	147	3	these	these	DET
bam-5830	147	4	assemblies	assembly	NOUN
bam-5830	147	5	of	of	ADP
bam-5830	147	6	postsynaptic	postsynaptic	ADJ
bam-5830	147	7	machinery	machinery	NOUN
bam-5830	147	8	undergo	undergo	VERB
bam-5830	147	9	similar	similar	ADJ
bam-5830	147	10	stages	stage	NOUN
bam-5830	147	11	in	in	ADP
bam-5830	147	12	developmental	developmental	ADJ
bam-5830	147	13	remodeling	remodeling	NOUN
bam-5830	147	14	from	from	ADP
bam-5830	147	15	“	"	PUNCT
bam-5830	147	16	plaques	plaque	NOUN
bam-5830	147	17	”	"	PUNCT
bam-5830	147	18	to	to	ADP
bam-5830	147	19	“	"	PUNCT
bam-5830	147	20	pretzels	pretzel	NOUN
bam-5830	147	21	”	"	PUNCT
bam-5830	147	22	as	as	ADP
bam-5830	147	23	those	those	PRON
bam-5830	147	24	formed	form	VERB
bam-5830	147	25	in	in	ADP
bam-5830	147	26	vivo	vivo	NOUN
bam-5830	147	27	.	.	PUNCT
bam-5830	148	1	we	we	PRON
bam-5830	148	2	have	have	AUX
bam-5830	148	3	recently	recently	ADV
bam-5830	148	4	demonstrated	demonstrate	VERB
bam-5830	148	5	that	that	SCONJ
bam-5830	148	6	podosomes	podosome	NOUN
bam-5830	148	7	,	,	PUNCT
bam-5830	148	8	actin	actin	NOUN
bam-5830	148	9	-	-	PUNCT
bam-5830	148	10	rich	rich	ADJ
bam-5830	148	11	adhesive	adhesive	ADJ
bam-5830	148	12	organelles	organelle	NOUN
bam-5830	148	13	,	,	PUNCT
bam-5830	148	14	promote	promote	VERB
bam-5830	148	15	the	the	DET
bam-5830	148	16	remodeling	remodeling	NOUN
bam-5830	148	17	process	process	NOUN
bam-5830	148	18	in	in	ADP
bam-5830	148	19	cultured	cultured	ADJ
bam-5830	148	20	myotubes	myotube	NOUN
bam-5830	148	21	and	and	CCONJ
bam-5830	148	22	showed	show	VERB
bam-5830	148	23	a	a	DET
bam-5830	148	24	key	key	ADJ
bam-5830	148	25	role	role	NOUN
bam-5830	148	26	of	of	ADP
bam-5830	148	27	one	one	NUM
bam-5830	148	28	podosome	podosome	ADJ
bam-5830	148	29	component	component	NOUN
bam-5830	148	30	,	,	PUNCT
bam-5830	148	31	amotl2	amotl2	PROPN
bam-5830	148	32	.	.	PUNCT
bam-5830	149	1	we	we	PRON
bam-5830	149	2	now	now	ADV
bam-5830	149	3	provide	provide	VERB
bam-5830	149	4	evidence	evidence	NOUN
bam-5830	149	5	that	that	SCONJ
bam-5830	149	6	several	several	ADJ
bam-5830	149	7	other	other	ADJ
bam-5830	149	8	known	know	VERB
bam-5830	149	9	podosome	podosome	NOUN
bam-5830	149	10	-	-	PUNCT
bam-5830	149	11	associated	associate	VERB
bam-5830	149	12	proteins	protein	NOUN
bam-5830	149	13	are	be	AUX
bam-5830	149	14	present	present	ADJ
bam-5830	149	15	at	at	ADP
bam-5830	149	16	the	the	DET
bam-5830	149	17	nmj	nmj	NOUN
bam-5830	149	18	in	in	ADP
bam-5830	149	19	vivo	vivo	NOUN
bam-5830	149	20	and	and	CCONJ
bam-5830	149	21	are	be	AUX
bam-5830	149	22	located	locate	VERB
bam-5830	149	23	to	to	ADP
bam-5830	149	24	the	the	DET
bam-5830	149	25	sites	site	NOUN
bam-5830	149	26	of	of	ADP
bam-5830	149	27	synaptic	synaptic	ADJ
bam-5830	149	28	remodeling	remodeling	NOUN
bam-5830	149	29	.	.	PUNCT
bam-5830	150	1	additionally	additionally	ADV
bam-5830	150	2	,	,	PUNCT
bam-5830	150	3	we	we	PRON
bam-5830	150	4	identified	identify	VERB
bam-5830	150	5	proteins	protein	NOUN
bam-5830	150	6	that	that	PRON
bam-5830	150	7	interact	interact	VERB
bam-5830	150	8	with	with	ADP
bam-5830	150	9	amotl2	amotl2	NOUN
bam-5830	150	10	in	in	ADP
bam-5830	150	11	muscle	muscle	NOUN
bam-5830	150	12	cells	cell	NOUN
bam-5830	150	13	.	.	PUNCT
bam-5830	151	1	we	we	PRON
bam-5830	151	2	show	show	VERB
bam-5830	151	3	that	that	SCONJ
bam-5830	151	4	two	two	NUM
bam-5830	151	5	of	of	ADP
bam-5830	151	6	them	they	PRON
bam-5830	151	7	:	:	PUNCT
bam-5830	151	8	rassf8	rassf8	PROPN
bam-5830	151	9	and	and	CCONJ
bam-5830	151	10	homer1	homer1	NOUN
bam-5830	151	11	,	,	PUNCT
bam-5830	151	12	together	together	ADV
bam-5830	151	13	with	with	ADP
bam-5830	151	14	other	other	ADJ
bam-5830	151	15	podosome	podosome	ADJ
bam-5830	151	16	components	component	NOUN
bam-5830	151	17	,	,	PUNCT
bam-5830	151	18	are	be	AUX
bam-5830	151	19	concentrated	concentrate	VERB
bam-5830	151	20	at	at	ADP
bam-5830	151	21	postsynaptic	postsynaptic	ADJ
bam-5830	151	22	areas	area	NOUN
bam-5830	151	23	of	of	ADP
bam-5830	151	24	nmjs	nmj	NOUN
bam-5830	151	25	in	in	ADP
bam-5830	151	26	the	the	DET
bam-5830	151	27	indentations	indentation	NOUN
bam-5830	151	28	between	between	ADP
bam-5830	151	29	the	the	DET
bam-5830	151	30	achr	achr	PROPN
bam-5830	151	31	-	-	PUNCT
bam-5830	151	32	rich	rich	ADJ
bam-5830	151	33	branches	branch	NOUN
bam-5830	151	34	.	.	PUNCT
bam-5830	152	1	our	our	PRON
bam-5830	152	2	results	result	NOUN
bam-5830	152	3	provide	provide	VERB
bam-5830	152	4	further	further	ADJ
bam-5830	152	5	support	support	NOUN
bam-5830	152	6	for	for	ADP
bam-5830	152	7	the	the	DET
bam-5830	152	8	hypothesis	hypothesis	NOUN
bam-5830	152	9	that	that	PRON
bam-5830	152	10	podosome	podosome	NOUN
bam-5830	152	11	-	-	PUNCT
bam-5830	152	12	like	like	ADJ
bam-5830	152	13	organelles	organelle	NOUN
bam-5830	152	14	are	be	AUX
bam-5830	152	15	involved	involve	VERB
bam-5830	152	16	in	in	ADP
bam-5830	152	17	synapse	synapse	NOUN
bam-5830	152	18	remodeling	remodeling	NOUN
bam-5830	152	19	and	and	CCONJ
bam-5830	152	20	that	that	DET
bam-5830	152	21	rassf8	rassf8	NOUN
bam-5830	152	22	and	and	CCONJ
bam-5830	152	23	homer1	homer1	PROPN
bam-5830	152	24	may	may	AUX
bam-5830	152	25	regulate	regulate	VERB
bam-5830	152	26	this	this	DET
bam-5830	152	27	process	process	NOUN
bam-5830	152	28	.	.	PUNCT
bam-5830	153	1	this	this	DET
bam-5830	153	2	research	research	NOUN
bam-5830	153	3	was	be	AUX
bam-5830	153	4	supported	support	VERB
bam-5830	153	5	by	by	ADP
bam-5830	153	6	the	the	DET
bam-5830	153	7	ncn	ncn	NOUN
bam-5830	153	8	grant	grant	PROPN
bam-5830	153	9	2012/05	2012/05	NUM
bam-5830	153	10	/	/	SYM
bam-5830	153	11	e	e	NOUN
bam-5830	153	12	/	/	SYM
bam-5830	153	13	nz3/00487	nz3/00487	PROPN
bam-5830	153	14	.	.	PUNCT
bam-5830	154	1	*	*	PUNCT
bam-5830	154	2	*	*	PUNCT
bam-5830	154	3	*	*	PUNCT
bam-5830	154	4	*	*	PUNCT
bam-5830	154	5	*	*	PUNCT
bam-5830	154	6	discovery	discovery	NOUN
bam-5830	154	7	of	of	ADP
bam-5830	154	8	junctions	junction	NOUN
bam-5830	154	9	mediating	mediate	VERB
bam-5830	154	10	store	store	NOUN
bam-5830	154	11	-	-	PUNCT
bam-5830	154	12	operated	operate	VERB
bam-5830	154	13	calcium	calcium	NOUN
bam-5830	154	14	entry	entry	NOUN
bam-5830	154	15	in	in	ADP
bam-5830	154	16	muscle	muscle	NOUN
bam-5830	154	17	s.	s.	PROPN
bam-5830	154	18	boncompagni	boncompagni	PROPN
bam-5830	154	19	*	*	PROPN
bam-5830	154	20	1	1	NUM
bam-5830	154	21	,	,	PUNCT
bam-5830	154	22	a.	a.	NOUN
bam-5830	154	23	michelucci	michelucci	NOUN
bam-5830	154	24	*	*	PROPN
bam-5830	154	25	1	1	NUM
bam-5830	154	26	,	,	PUNCT
bam-5830	154	27	l.	l.	PROPN
bam-5830	154	28	pietrangelo	pietrangelo	PROPN
bam-5830	154	29	1	1	NUM
bam-5830	154	30	,	,	PUNCT
bam-5830	154	31	r.t	r.t	PROPN
bam-5830	154	32	.	.	PROPN
bam-5830	154	33	dirksen	dirksen	PROPN
bam-5830	154	34	2	2	NUM
bam-5830	154	35	,	,	PUNCT
bam-5830	154	36	f.	f.	PROPN
bam-5830	154	37	protasi	protasi	PROPN
bam-5830	155	1	1	1	NUM
bam-5830	155	2	*	*	NOUN
bam-5830	155	3	these	these	DET
bam-5830	155	4	authors	author	NOUN
bam-5830	155	5	contributed	contribute	VERB
bam-5830	155	6	equally	equally	ADV
bam-5830	155	7	to	to	ADP
bam-5830	155	8	this	this	DET
bam-5830	155	9	work	work	NOUN
bam-5830	155	10	.	.	PUNCT
bam-5830	156	1	1	1	X
bam-5830	156	2	.	.	X
bam-5830	156	3	cesi	cesi	PROPN
bam-5830	156	4	center	center	PROPN
bam-5830	156	5	for	for	ADP
bam-5830	156	6	research	research	NOUN
bam-5830	156	7	on	on	ADP
bam-5830	156	8	ageing	ageing	NOUN
bam-5830	156	9	&	&	CCONJ
bam-5830	156	10	dnics	dnic	NOUN
bam-5830	156	11	dept	dept	PROPN
bam-5830	156	12	.	.	PROPN
bam-5830	156	13	of	of	ADP
bam-5830	156	14	neuroscience	neuroscience	NOUN
bam-5830	156	15	,	,	PUNCT
bam-5830	156	16	imaging	imaging	NOUN
bam-5830	156	17	and	and	CCONJ
bam-5830	156	18	clinical	clinical	ADJ
bam-5830	156	19	sciences	science	NOUN
bam-5830	156	20	,	,	PUNCT
bam-5830	156	21	university	university	NOUN
bam-5830	156	22	g.	g.	PROPN
bam-5830	156	23	d’annunzio	d’annunzio	PROPN
bam-5830	156	24	of	of	ADP
bam-5830	156	25	chieti	chieti	PROPN
bam-5830	156	26	,	,	PUNCT
bam-5830	156	27	i-66013	i-66013	PROPN
bam-5830	156	28	italy	italy	PROPN
bam-5830	156	29	;	;	PUNCT
bam-5830	156	30	2	2	X
bam-5830	156	31	.	.	X
bam-5830	156	32	dept	dept	NOUN
bam-5830	156	33	.	.	PROPN
bam-5830	156	34	of	of	ADP
bam-5830	156	35	pharmacology	pharmacology	NOUN
bam-5830	156	36	and	and	CCONJ
bam-5830	156	37	physiology	physiology	NOUN
bam-5830	156	38	,	,	PUNCT
bam-5830	156	39	university	university	NOUN
bam-5830	156	40	of	of	ADP
bam-5830	156	41	rochester	rochester	PROPN
bam-5830	156	42	medical	medical	ADJ
bam-5830	156	43	center	center	NOUN
bam-5830	156	44	,	,	PUNCT
bam-5830	156	45	rochester	rochester	PROPN
bam-5830	156	46	,	,	PUNCT
bam-5830	156	47	ny	ny	PROPN
bam-5830	156	48	,	,	PUNCT
bam-5830	156	49	usa	usa	PROPN
bam-5830	156	50	e	e	PROPN
bam-5830	156	51	-	-	NOUN
bam-5830	156	52	mail	mail	NOUN
bam-5830	156	53	:	:	PUNCT
bam-5830	156	54	s.boncompagni@unich.it	s.boncompagni@unich.it	PUNCT
bam-5830	157	1	depletion	depletion	NOUN
bam-5830	157	2	of	of	ADP
bam-5830	157	3	calcium	calcium	NOUN
bam-5830	157	4	(	(	PUNCT
bam-5830	157	5	ca2	ca2	PROPN
bam-5830	157	6	+	+	PROPN
bam-5830	157	7	)	)	PUNCT
bam-5830	157	8	from	from	ADP
bam-5830	157	9	intracellular	intracellular	ADJ
bam-5830	157	10	stores	store	NOUN
bam-5830	157	11	(	(	PUNCT
bam-5830	157	12	endoplasmic	endoplasmic	ADJ
bam-5830	157	13	reticulum	reticulum	NOUN
bam-5830	157	14	,	,	PUNCT
bam-5830	157	15	er	er	INTJ
bam-5830	157	16	)	)	PUNCT
bam-5830	157	17	,	,	PUNCT
bam-5830	157	18	triggers	trigger	VERB
bam-5830	157	19	ca2	ca2	PROPN
bam-5830	157	20	+	+	PROPN
bam-5830	157	21	entry	entry	NOUN
bam-5830	157	22	across	across	ADP
bam-5830	157	23	the	the	DET
bam-5830	157	24	plasma	plasma	NOUN
bam-5830	157	25	membrane	membrane	NOUN
bam-5830	157	26	,	,	PUNCT
bam-5830	157	27	a	a	DET
bam-5830	157	28	process	process	NOUN
bam-5830	157	29	known	know	VERB
bam-5830	157	30	as	as	ADP
bam-5830	157	31	store	store	NOUN
bam-5830	157	32	-	-	PUNCT
bam-5830	157	33	operated	operate	VERB
bam-5830	157	34	ca2	ca2	PROPN
bam-5830	157	35	+	+	NOUN
bam-5830	157	36	entry	entry	NOUN
bam-5830	157	37	(	(	PUNCT
bam-5830	157	38	soce	soce	NOUN
bam-5830	157	39	)	)	PUNCT
bam-5830	157	40	.	.	PUNCT
bam-5830	158	1	soce	soce	NOUN
bam-5830	158	2	is	be	AUX
bam-5830	158	3	mediated	mediate	VERB
bam-5830	158	4	by	by	ADP
bam-5830	158	5	the	the	DET
bam-5830	158	6	interaction	interaction	NOUN
bam-5830	158	7	between	between	ADP
bam-5830	158	8	stim1	stim1	NOUN
bam-5830	158	9	(	(	PUNCT
bam-5830	158	10	stromal	stromal	ADJ
bam-5830	158	11	interaction	interaction	NOUN
bam-5830	158	12	molecule	molecule	NOUN
bam-5830	158	13	1	1	NUM
bam-5830	158	14	)	)	PUNCT
bam-5830	158	15	,	,	PUNCT
bam-5830	158	16	which	which	PRON
bam-5830	158	17	functions	function	NOUN
bam-5830	158	18	as	as	ADP
bam-5830	158	19	the	the	DET
bam-5830	158	20	ca2	ca2	PROPN
bam-5830	158	21	+	+	PROPN
bam-5830	158	22	sensor	sensor	NOUN
bam-5830	158	23	in	in	ADP
bam-5830	158	24	the	the	DET
bam-5830	158	25	er	er	INTJ
bam-5830	158	26	,	,	PUNCT
bam-5830	158	27	and	and	CCONJ
bam-5830	158	28	ca2	ca2	PROPN
bam-5830	158	29	+	+	CCONJ
bam-5830	158	30	permeable	permeable	ADJ
bam-5830	158	31	orai1	orai1	NOUN
bam-5830	158	32	channels	channel	NOUN
bam-5830	158	33	in	in	ADP
bam-5830	158	34	the	the	DET
bam-5830	158	35	external	external	ADJ
bam-5830	158	36	membrane	membrane	NOUN
bam-5830	158	37	.	.	PUNCT
bam-5830	159	1	in	in	ADP
bam-5830	159	2	skeletal	skeletal	ADJ
bam-5830	159	3	muscle	muscle	NOUN
bam-5830	159	4	,	,	PUNCT
bam-5830	159	5	soce	soce	NOUN
bam-5830	159	6	is	be	AUX
bam-5830	159	7	the	the	DET
bam-5830	159	8	primary	primary	ADJ
bam-5830	159	9	mechanism	mechanism	NOUN
bam-5830	159	10	of	of	ADP
bam-5830	159	11	ca2	ca2	PROPN
bam-5830	159	12	+	+	NOUN
bam-5830	159	13	entry	entry	NOUN
bam-5830	159	14	during	during	ADP
bam-5830	159	15	repetitive	repetitive	ADJ
bam-5830	159	16	activity	activity	NOUN
bam-5830	159	17	,	,	PUNCT
bam-5830	159	18	a	a	DET
bam-5830	159	19	crucial	crucial	ADJ
bam-5830	159	20	step	step	NOUN
bam-5830	159	21	that	that	PRON
bam-5830	159	22	prevents	prevent	VERB
bam-5830	159	23	/	/	SYM
bam-5830	159	24	delays	delay	NOUN
bam-5830	159	25	fatigue	fatigue	NOUN
bam-5830	159	26	.	.	PUNCT
bam-5830	160	1	despite	despite	SCONJ
bam-5830	160	2	the	the	DET
bam-5830	160	3	importance	importance	NOUN
bam-5830	160	4	of	of	ADP
bam-5830	160	5	this	this	DET
bam-5830	160	6	mechanism	mechanism	NOUN
bam-5830	160	7	for	for	ADP
bam-5830	160	8	proper	proper	ADJ
bam-5830	160	9	muscle	muscle	NOUN
bam-5830	160	10	function	function	NOUN
bam-5830	160	11	during	during	ADP
bam-5830	160	12	sustained	sustained	ADJ
bam-5830	160	13	activity	activity	NOUN
bam-5830	160	14	,	,	PUNCT
bam-5830	160	15	the	the	DET
bam-5830	160	16	subcellular	subcellular	ADJ
bam-5830	160	17	sites	site	NOUN
bam-5830	160	18	for	for	ADP
bam-5830	160	19	soce	soce	NOUN
bam-5830	160	20	in	in	ADP
bam-5830	160	21	skeletal	skeletal	ADJ
bam-5830	160	22	fibers	fiber	NOUN
bam-5830	160	23	have	have	AUX
bam-5830	160	24	not	not	PART
bam-5830	160	25	been	be	AUX
bam-5830	160	26	identified	identify	VERB
bam-5830	160	27	.	.	PUNCT
bam-5830	161	1	here	here	ADV
bam-5830	161	2	we	we	PRON
bam-5830	161	3	show	show	VERB
bam-5830	161	4	that	that	SCONJ
bam-5830	161	5	prolonged	prolonged	ADJ
bam-5830	161	6	muscle	muscle	NOUN
bam-5830	161	7	activity	activity	NOUN
bam-5830	161	8	(	(	PUNCT
bam-5830	161	9	treadmill	treadmill	NOUN
bam-5830	161	10	running	run	VERB
bam-5830	161	11	in	in	ADP
bam-5830	161	12	mice	mouse	NOUN
bam-5830	161	13	)	)	PUNCT
bam-5830	161	14	drives	drive	VERB
bam-5830	161	15	the	the	DET
bam-5830	161	16	formation	formation	NOUN
bam-5830	161	17	of	of	ADP
bam-5830	161	18	previously	previously	ADV
bam-5830	161	19	unidentified	unidentified	ADJ
bam-5830	161	20	intracellular	intracellular	ADJ
bam-5830	161	21	junctions	junction	NOUN
bam-5830	161	22	between	between	ADP
bam-5830	161	23	the	the	DET
bam-5830	161	24	sarcoplasmic	sarcoplasmic	NOUN
bam-5830	161	25	reticulum	reticulum	NOUN
bam-5830	161	26	(	(	PUNCT
bam-5830	161	27	sr	sr	PROPN
bam-5830	161	28	)	)	PUNCT
bam-5830	161	29	and	and	CCONJ
bam-5830	161	30	extensions	extension	NOUN
bam-5830	161	31	of	of	ADP
bam-5830	161	32	the	the	DET
bam-5830	161	33	external	external	ADJ
bam-5830	161	34	transverse	transverse	NOUN
bam-5830	161	35	tubule	tubule	NOUN
bam-5830	161	36	(	(	PUNCT
bam-5830	161	37	tt	tt	NOUN
bam-5830	161	38	)	)	PUNCT
bam-5830	161	39	membrane	membrane	NOUN
bam-5830	161	40	.	.	PUNCT
bam-5830	162	1	the	the	DET
bam-5830	162	2	activity	activity	NOUN
bam-5830	162	3	-	-	PUNCT
bam-5830	162	4	dependent	dependent	ADJ
bam-5830	162	5	formation	formation	NOUN
bam-5830	162	6	of	of	ADP
bam-5830	162	7	these	these	DET
bam-5830	162	8	unique	unique	ADJ
bam-5830	162	9	sr	sr	PROPN
bam-5830	162	10	-	-	PUNCT
bam-5830	162	11	tt	tt	PROPN
bam-5830	162	12	junctions	junction	NOUN
bam-5830	162	13	reflects	reflect	VERB
bam-5830	162	14	a	a	DET
bam-5830	162	15	striking	striking	ADJ
bam-5830	162	16	and	and	CCONJ
bam-5830	162	17	unexpected	unexpected	ADJ
bam-5830	162	18	remodeling	remodeling	NOUN
bam-5830	162	19	of	of	ADP
bam-5830	162	20	the	the	DET
bam-5830	162	21	existing	exist	VERB
bam-5830	162	22	sarcotubular	sarcotubular	ADJ
bam-5830	162	23	system	system	NOUN
bam-5830	162	24	at	at	ADP
bam-5830	162	25	the	the	DET
bam-5830	162	26	i	i	PROPN
bam-5830	162	27	band	band	NOUN
bam-5830	162	28	of	of	ADP
bam-5830	162	29	the	the	DET
bam-5830	162	30	sarcomere	sarcomere	NOUN
bam-5830	162	31	.	.	PUNCT
bam-5830	163	1	using	use	VERB
bam-5830	163	2	immunochemistry	immunochemistry	PROPN
bam-5830	163	3	and	and	CCONJ
bam-5830	163	4	immuno	immuno	ADJ
bam-5830	163	5	-	-	PUNCT
bam-5830	163	6	gold	gold	ADJ
bam-5830	163	7	labeling	labeling	NOUN
bam-5830	163	8	we	we	PRON
bam-5830	163	9	also	also	ADV
bam-5830	163	10	demonstrate	demonstrate	VERB
bam-5830	163	11	that	that	SCONJ
bam-5830	163	12	these	these	DET
bam-5830	163	13	newly	newly	ADV
bam-5830	163	14	formed	form	VERB
bam-5830	163	15	,	,	PUNCT
bam-5830	163	16	activity	activity	NOUN
bam-5830	163	17	-	-	PUNCT
bam-5830	163	18	driven	drive	VERB
bam-5830	163	19	junctions	junction	NOUN
bam-5830	163	20	contain	contain	VERB
bam-5830	163	21	the	the	DET
bam-5830	163	22	molecular	molecular	ADJ
bam-5830	163	23	machinery	machinery	NOUN
bam-5830	163	24	known	know	VERB
bam-5830	163	25	to	to	PART
bam-5830	163	26	mediate	mediate	VERB
bam-5830	163	27	soce	soce	NOUN
bam-5830	163	28	in	in	ADP
bam-5830	163	29	muscle	muscle	NOUN
bam-5830	163	30	:	:	PUNCT
bam-5830	163	31	stim1	stim1	PROPN
bam-5830	163	32	ca2	ca2	PROPN
bam-5830	163	33	+	+	PROPN
bam-5830	163	34	sensor	sensor	NOUN
bam-5830	163	35	proteins	protein	NOUN
bam-5830	163	36	in	in	ADP
bam-5830	163	37	the	the	DET
bam-5830	163	38	sr	sr	PROPN
bam-5830	163	39	,	,	PUNCT
bam-5830	163	40	already	already	ADV
bam-5830	163	41	present	present	ADJ
bam-5830	163	42	in	in	ADP
bam-5830	163	43	the	the	DET
bam-5830	163	44	i	i	PROPN
bam-5830	163	45	band	band	NOUN
bam-5830	163	46	in	in	ADP
bam-5830	163	47	control	control	NOUN
bam-5830	163	48	conditions	condition	NOUN
bam-5830	163	49	,	,	PUNCT
bam-5830	163	50	and	and	CCONJ
bam-5830	163	51	ca2+permeable	ca2+permeable	NOUN
bam-5830	163	52	orai1	orai1	NOUN
bam-5830	163	53	channels	channel	NOUN
bam-5830	163	54	,	,	PUNCT
bam-5830	163	55	which	which	PRON
bam-5830	163	56	move	move	VERB
bam-5830	163	57	into	into	ADP
bam-5830	163	58	the	the	DET
bam-5830	163	59	i	i	PROPN
bam-5830	163	60	band	band	NOUN
bam-5830	163	61	with	with	ADP
bam-5830	163	62	tts	tts	PROPN
bam-5830	163	63	during	during	ADP
bam-5830	163	64	prolonged	prolonged	ADJ
bam-5830	163	65	muscle	muscle	NOUN
bam-5830	163	66	activity	activity	NOUN
bam-5830	163	67	.	.	PUNCT
bam-5830	164	1	thus	thus	ADV
bam-5830	164	2	,	,	PUNCT
bam-5830	164	3	we	we	PRON
bam-5830	164	4	refer	refer	VERB
bam-5830	164	5	to	to	ADP
bam-5830	164	6	these	these	DET
bam-5830	164	7	junctions	junction	NOUN
bam-5830	164	8	as	as	ADP
bam-5830	164	9	ca2	ca2	PROPN
bam-5830	164	10	+	+	CCONJ
bam-5830	164	11	entry	entry	NOUN
bam-5830	164	12	units	unit	NOUN
bam-5830	164	13	,	,	PUNCT
bam-5830	164	14	the	the	DET
bam-5830	164	15	first	first	ADJ
bam-5830	164	16	new	new	ADJ
bam-5830	164	17	,	,	PUNCT
bam-5830	164	18	molecularly	molecularly	ADV
bam-5830	164	19	defined	define	VERB
bam-5830	164	20	subcellular	subcellular	ADJ
bam-5830	164	21	structure	structure	NOUN
bam-5830	164	22	in	in	ADP
bam-5830	164	23	skeletal	skeletal	ADJ
bam-5830	164	24	muscle	muscle	NOUN
bam-5830	164	25	in	in	ADP
bam-5830	164	26	over	over	ADP
bam-5830	164	27	30	30	NUM
bam-5830	164	28	years	year	NOUN
bam-5830	164	29	.	.	PUNCT
bam-5830	165	1	*	*	PUNCT
bam-5830	165	2	*	*	PUNCT
bam-5830	165	3	*	*	PUNCT
bam-5830	165	4	*	*	PUNCT
bam-5830	165	5	*	*	ADJ
bam-5830	165	6	muscle	muscle	NOUN
bam-5830	165	7	-	-	PUNCT
bam-5830	165	8	nerve	nerve	NOUN
bam-5830	165	9	communication	communication	NOUN
bam-5830	165	10	in	in	ADP
bam-5830	165	11	murine	murine	ADJ
bam-5830	165	12	models	model	NOUN
bam-5830	165	13	of	of	ADP
bam-5830	165	14	amyotrophic	amyotrophic	ADJ
bam-5830	165	15	lateral	lateral	ADJ
bam-5830	165	16	sclerosis	sclerosis	NOUN
bam-5830	165	17	s.	s.	PROPN
bam-5830	165	18	pisu	pisu	PROPN
bam-5830	165	19	1	1	NUM
bam-5830	165	20	,	,	PUNCT
bam-5830	165	21	e.	e.	PROPN
bam-5830	165	22	rizzuto	rizzuto	PROPN
bam-5830	165	23	2	2	NUM
bam-5830	165	24	,	,	PUNCT
bam-5830	165	25	z.	z.	PROPN
bam-5830	165	26	del	del	PROPN
bam-5830	165	27	prete	prete	PROPN
bam-5830	165	28	2	2	NUM
bam-5830	165	29	,	,	PUNCT
bam-5830	165	30	a.	a.	NOUN
bam-5830	165	31	musarò	musarò	NOUN
bam-5830	165	32	1	1	NUM
bam-5830	165	33	1	1	NUM
bam-5830	165	34	.	.	PUNCT
bam-5830	166	1	dahfmo	dahfmo	NOUN
bam-5830	166	2	-	-	PUNCT
bam-5830	166	3	unit	unit	NOUN
bam-5830	166	4	of	of	ADP
bam-5830	166	5	histology	histology	NOUN
bam-5830	166	6	and	and	CCONJ
bam-5830	166	7	medical	medical	ADJ
bam-5830	166	8	embryology	embryology	PROPN
bam-5830	166	9	,	,	PUNCT
bam-5830	166	10	sapienza	sapienza	PROPN
bam-5830	166	11	university	university	PROPN
bam-5830	166	12	of	of	ADP
bam-5830	166	13	rome	rome	PROPN
bam-5830	166	14	,	,	PUNCT
bam-5830	166	15	italy	italy	PROPN
bam-5830	166	16	;	;	PUNCT
bam-5830	166	17	2	2	X
bam-5830	166	18	.	.	X
bam-5830	166	19	department	department	NOUN
bam-5830	166	20	of	of	ADP
bam-5830	166	21	mechanical	mechanical	ADJ
bam-5830	166	22	and	and	CCONJ
bam-5830	166	23	aerospace	aerospace	NOUN
bam-5830	166	24	engineering	engineering	NOUN
bam-5830	166	25	,	,	PUNCT
bam-5830	166	26	sapienza	sapienza	PROPN
bam-5830	166	27	university	university	PROPN
bam-5830	166	28	of	of	ADP
bam-5830	166	29	rome	rome	PROPN
bam-5830	166	30	.	.	PUNCT
bam-5830	167	1	e	e	X
bam-5830	167	2	-	-	NOUN
bam-5830	167	3	mail	mail	NOUN
bam-5830	167	4	:	:	PUNCT
bam-5830	167	5	simona.pisu@uniroma1.it	simona.pisu@uniroma1.it	NOUN
bam-5830	167	6	the	the	DET
bam-5830	167	7	loss	loss	NOUN
bam-5830	167	8	of	of	ADP
bam-5830	167	9	connection	connection	NOUN
bam-5830	167	10	between	between	ADP
bam-5830	167	11	muscle	muscle	NOUN
bam-5830	167	12	and	and	CCONJ
bam-5830	167	13	nerve	nerve	NOUN
bam-5830	167	14	is	be	AUX
bam-5830	167	15	a	a	DET
bam-5830	167	16	crucial	crucial	ADJ
bam-5830	167	17	biological	biological	ADJ
bam-5830	167	18	mechanism	mechanism	NOUN
bam-5830	167	19	involved	involve	VERB
bam-5830	167	20	in	in	ADP
bam-5830	167	21	amyotrophic	amyotrophic	ADJ
bam-5830	167	22	lateral	lateral	ADJ
bam-5830	167	23	sclerosis	sclerosis	NOUN
bam-5830	167	24	(	(	PUNCT
bam-5830	167	25	als	als	NOUN
bam-5830	167	26	)	)	PUNCT
bam-5830	167	27	,	,	PUNCT
bam-5830	167	28	a	a	DET
bam-5830	167	29	neurodegenerative	neurodegenerative	ADJ
bam-5830	167	30	disease	disease	NOUN
bam-5830	167	31	associated	associate	VERB
bam-5830	167	32	with	with	ADP
bam-5830	167	33	motor	motor	PROPN
bam-5830	167	34	neuron	neuron	PROPN
bam-5830	167	35	degeneration	degeneration	NOUN
bam-5830	167	36	,	,	PUNCT
bam-5830	167	37	muscle	muscle	NOUN
bam-5830	167	38	atrophy	atrophy	NOUN
bam-5830	167	39	and	and	CCONJ
bam-5830	167	40	paralysis	paralysis	NOUN
bam-5830	167	41	[	[	X
bam-5830	167	42	1	1	NUM
bam-5830	167	43	]	]	PUNCT
bam-5830	167	44	.	.	PUNCT
bam-5830	168	1	recent	recent	ADJ
bam-5830	168	2	studies	study	NOUN
bam-5830	168	3	showed	show	VERB
bam-5830	168	4	the	the	DET
bam-5830	168	5	primary	primary	ADJ
bam-5830	168	6	role	role	NOUN
bam-5830	168	7	of	of	ADP
bam-5830	168	8	the	the	DET
bam-5830	168	9	skeletal	skeletal	ADJ
bam-5830	168	10	muscle	muscle	NOUN
bam-5830	168	11	in	in	ADP
bam-5830	168	12	the	the	DET
bam-5830	168	13	pathogenesis	pathogenesis	NOUN
bam-5830	168	14	of	of	ADP
bam-5830	168	15	the	the	DET
bam-5830	168	16	disease	disease	NOUN
bam-5830	168	17	,	,	PUNCT
bam-5830	168	18	pointing	point	VERB
bam-5830	168	19	out	out	ADP
bam-5830	168	20	the	the	DET
bam-5830	168	21	key	key	ADJ
bam-5830	168	22	role	role	NOUN
bam-5830	168	23	of	of	ADP
bam-5830	168	24	the	the	DET
bam-5830	168	25	communication	communication	NOUN
bam-5830	168	26	between	between	ADP
bam-5830	168	27	muscle	muscle	NOUN
bam-5830	168	28	and	and	CCONJ
bam-5830	168	29	nerve	nerve	NOUN
bam-5830	168	30	.	.	PUNCT
bam-5830	169	1	in	in	ADP
bam-5830	169	2	this	this	DET
bam-5830	169	3	context	context	NOUN
bam-5830	169	4	,	,	PUNCT
bam-5830	169	5	we	we	PRON
bam-5830	169	6	developed	develop	VERB
bam-5830	169	7	a	a	DET
bam-5830	169	8	protocol	protocol	NOUN
bam-5830	169	9	to	to	PART
bam-5830	169	10	measure	measure	VERB
bam-5830	169	11	,	,	PUNCT
bam-5830	169	12	ex	ex	NOUN
bam-5830	169	13	vivo	vivo	NOUN
bam-5830	169	14	,	,	PUNCT
bam-5830	169	15	the	the	DET
bam-5830	169	16	neuromuscular	neuromuscular	ADJ
bam-5830	169	17	junction	junction	NOUN
bam-5830	169	18	(	(	PUNCT
bam-5830	169	19	nmj	nmj	NOUN
bam-5830	169	20	)	)	PUNCT
bam-5830	169	21	functionality	functionality	NOUN
bam-5830	170	1	[	[	X
bam-5830	170	2	2	2	NUM
bam-5830	170	3	]	]	PUNCT
bam-5830	170	4	.	.	PUNCT
bam-5830	171	1	the	the	DET
bam-5830	171	2	experimental	experimental	ADJ
bam-5830	171	3	technique	technique	NOUN
bam-5830	171	4	is	be	AUX
bam-5830	171	5	based	base	VERB
bam-5830	171	6	on	on	ADP
bam-5830	171	7	the	the	DET
bam-5830	171	8	comparison	comparison	NOUN
bam-5830	171	9	between	between	ADP
bam-5830	171	10	the	the	DET
bam-5830	171	11	muscle	muscle	NOUN
bam-5830	171	12	contractile	contractile	NOUN
bam-5830	171	13	response	response	NOUN
bam-5830	171	14	elicited	elicit	VERB
bam-5830	171	15	by	by	ADP
bam-5830	171	16	membrane	membrane	NOUN
bam-5830	171	17	abstracts	abstract	NOUN
bam-5830	171	18	of	of	ADP
bam-5830	171	19	the	the	DET
bam-5830	171	20	xii	xii	PROPN
bam-5830	171	21	iim	iim	NOUN
bam-5830	171	22	myology	myology	NOUN
bam-5830	171	23	meeting	meeting	NOUN
bam-5830	171	24	october	october	PROPN
bam-5830	171	25	1–4	1–4	PROPN
bam-5830	171	26	,	,	PUNCT
bam-5830	171	27	2015	2015	NUM
bam-5830	171	28	eur	eur	PROPN
bam-5830	171	29	j	j	PROPN
bam-5830	171	30	transl	transl	PROPN
bam-5830	171	31	myol	myol	PROPN
bam-5830	171	32	basic	basic	ADJ
bam-5830	171	33	appl	appl	NOUN
bam-5830	171	34	myol	myol	NOUN
bam-5830	171	35	2016	2016	NUM
bam-5830	171	36	;	;	PUNCT
bam-5830	171	37	26	26	NUM
bam-5830	171	38	(	(	PUNCT
bam-5830	171	39	1):2	1):2	NUM
bam-5830	171	40	-	-	SYM
bam-5830	171	41	24	24	NUM
bam-5830	171	42	this	this	DET
bam-5830	171	43	article	article	NOUN
bam-5830	171	44	is	be	AUX
bam-5830	171	45	distributed	distribute	VERB
bam-5830	171	46	under	under	ADP
bam-5830	171	47	the	the	DET
bam-5830	171	48	terms	term	NOUN
bam-5830	171	49	of	of	ADP
bam-5830	171	50	the	the	DET
bam-5830	171	51	creative	creative	ADJ
bam-5830	171	52	commons	common	NOUN
bam-5830	171	53	attribution	attribution	NOUN
bam-5830	171	54	noncommercial	noncommercial	ADJ
bam-5830	171	55	license	license	NOUN
bam-5830	171	56	(	(	PUNCT
bam-5830	171	57	cc	cc	NOUN
bam-5830	171	58	by	by	ADP
bam-5830	171	59	-	-	PUNCT
bam-5830	171	60	nc	nc	PROPN
bam-5830	171	61	4.0	4.0	NUM
bam-5830	171	62	)	)	PUNCT
bam-5830	171	63	which	which	PRON
bam-5830	171	64	permits	permit	VERB
bam-5830	171	65	any	any	DET
bam-5830	171	66	noncommercial	noncommercial	ADJ
bam-5830	171	67	use	use	NOUN
bam-5830	171	68	,	,	PUNCT
bam-5830	171	69	distribution	distribution	NOUN
bam-5830	171	70	,	,	PUNCT
bam-5830	171	71	and	and	CCONJ
bam-5830	171	72	reproduction	reproduction	NOUN
bam-5830	171	73	in	in	ADP
bam-5830	171	74	any	any	DET
bam-5830	171	75	medium	medium	NOUN
bam-5830	171	76	,	,	PUNCT
bam-5830	171	77	provided	provide	VERB
bam-5830	171	78	the	the	DET
bam-5830	171	79	original	original	ADJ
bam-5830	171	80	author(s	author(s	NOUN
bam-5830	171	81	)	)	PUNCT
bam-5830	171	82	and	and	CCONJ
bam-5830	171	83	source	source	NOUN
bam-5830	171	84	are	be	AUX
bam-5830	171	85	credited	credit	VERB
bam-5830	171	86	.	.	PUNCT
bam-5830	172	1	8	8	NUM
bam-5830	172	2	stimulation	stimulation	NOUN
bam-5830	172	3	and	and	CCONJ
bam-5830	172	4	the	the	DET
bam-5830	172	5	response	response	NOUN
bam-5830	172	6	evoked	evoke	VERB
bam-5830	172	7	by	by	ADP
bam-5830	172	8	nerve	nerve	NOUN
bam-5830	172	9	stimulation	stimulation	NOUN
bam-5830	172	10	.	.	PUNCT
bam-5830	173	1	since	since	SCONJ
bam-5830	173	2	this	this	DET
bam-5830	173	3	latter	latter	ADJ
bam-5830	173	4	stimulation	stimulation	NOUN
bam-5830	173	5	bypasses	bypass	VERB
bam-5830	173	6	the	the	DET
bam-5830	173	7	neuronal	neuronal	ADJ
bam-5830	173	8	signalling	signalling	NOUN
bam-5830	173	9	,	,	PUNCT
bam-5830	173	10	any	any	DET
bam-5830	173	11	difference	difference	NOUN
bam-5830	173	12	between	between	ADP
bam-5830	173	13	the	the	DET
bam-5830	173	14	two	two	NUM
bam-5830	173	15	responses	response	NOUN
bam-5830	173	16	may	may	AUX
bam-5830	173	17	be	be	AUX
bam-5830	173	18	related	relate	VERB
bam-5830	173	19	to	to	ADP
bam-5830	173	20	nmj	nmj	NOUN
bam-5830	173	21	alterations	alteration	NOUN
bam-5830	173	22	.	.	PUNCT
bam-5830	174	1	in	in	ADP
bam-5830	174	2	particular	particular	ADJ
bam-5830	174	3	,	,	PUNCT
bam-5830	174	4	we	we	PRON
bam-5830	174	5	started	start	VERB
bam-5830	174	6	studying	study	VERB
bam-5830	174	7	the	the	DET
bam-5830	174	8	soleus	soleus	NOUN
bam-5830	174	9	-	-	PUNCT
bam-5830	174	10	sciatic	sciatic	ADJ
bam-5830	174	11	nerve	nerve	NOUN
bam-5830	174	12	preparation	preparation	NOUN
bam-5830	174	13	of	of	ADP
bam-5830	174	14	one	one	NUM
bam-5830	174	15	of	of	ADP
bam-5830	174	16	the	the	DET
bam-5830	174	17	most	most	ADV
bam-5830	174	18	studied	study	VERB
bam-5830	174	19	als	als	NOUN
bam-5830	174	20	animal	animal	NOUN
bam-5830	174	21	models	model	NOUN
bam-5830	174	22	,	,	PUNCT
bam-5830	174	23	the	the	DET
bam-5830	174	24	sod1g93a	sod1g93a	PROPN
bam-5830	174	25	mouse	mouse	NOUN
bam-5830	174	26	[	[	X
bam-5830	174	27	3	3	NUM
bam-5830	174	28	]	]	PUNCT
bam-5830	174	29	,	,	PUNCT
bam-5830	174	30	with	with	ADP
bam-5830	174	31	the	the	DET
bam-5830	174	32	particular	particular	ADJ
bam-5830	174	33	aim	aim	NOUN
bam-5830	174	34	of	of	ADP
bam-5830	174	35	following	follow	VERB
bam-5830	174	36	the	the	DET
bam-5830	174	37	pathology	pathology	NOUN
bam-5830	174	38	’s	’s	PART
bam-5830	174	39	progress	progress	NOUN
bam-5830	174	40	.	.	PUNCT
bam-5830	175	1	we	we	PRON
bam-5830	175	2	observed	observe	VERB
bam-5830	175	3	that	that	SCONJ
bam-5830	175	4	the	the	DET
bam-5830	175	5	first	first	ADJ
bam-5830	175	6	functional	functional	ADJ
bam-5830	175	7	alterations	alteration	NOUN
bam-5830	175	8	begin	begin	VERB
bam-5830	175	9	at	at	ADP
bam-5830	175	10	90	90	NUM
bam-5830	175	11	days	day	NOUN
bam-5830	175	12	of	of	ADP
bam-5830	175	13	age	age	NOUN
bam-5830	175	14	,	,	PUNCT
bam-5830	175	15	with	with	ADP
bam-5830	175	16	an	an	DET
bam-5830	175	17	intrinsic	intrinsic	ADJ
bam-5830	175	18	damage	damage	NOUN
bam-5830	175	19	of	of	ADP
bam-5830	175	20	the	the	DET
bam-5830	175	21	muscle	muscle	NOUN
bam-5830	175	22	and	and	CCONJ
bam-5830	175	23	defects	defect	NOUN
bam-5830	175	24	in	in	ADP
bam-5830	175	25	nmj	nmj	NOUN
bam-5830	175	26	functionality	functionality	NOUN
bam-5830	175	27	who	who	PRON
bam-5830	175	28	increase	increase	VERB
bam-5830	175	29	until	until	ADP
bam-5830	175	30	the	the	DET
bam-5830	175	31	end	end	NOUN
bam-5830	175	32	-	-	PUNCT
bam-5830	175	33	stage	stage	NOUN
bam-5830	175	34	of	of	ADP
bam-5830	175	35	the	the	DET
bam-5830	175	36	disease	disease	NOUN
bam-5830	175	37	.	.	PUNCT
bam-5830	176	1	subsequently	subsequently	ADV
bam-5830	176	2	,	,	PUNCT
bam-5830	176	3	we	we	PRON
bam-5830	176	4	approached	approach	VERB
bam-5830	176	5	the	the	DET
bam-5830	176	6	study	study	NOUN
bam-5830	176	7	of	of	ADP
bam-5830	176	8	the	the	DET
bam-5830	176	9	mlc	mlc	PROPN
bam-5830	176	10	/	/	SYM
bam-5830	176	11	sod1g93a	sod1g93a	PROPN
bam-5830	176	12	mouse	mouse	PROPN
bam-5830	176	13	model	model	NOUN
bam-5830	176	14	,	,	PUNCT
bam-5830	176	15	in	in	ADP
bam-5830	176	16	which	which	PRON
bam-5830	176	17	superoxyde	superoxyde	NOUN
bam-5830	176	18	dismutase-1	dismutase-1	PROPN
bam-5830	176	19	mutated	mutate	VERB
bam-5830	176	20	gene	gene	NOUN
bam-5830	176	21	is	be	AUX
bam-5830	176	22	expressed	express	VERB
bam-5830	176	23	exclusively	exclusively	ADV
bam-5830	176	24	in	in	ADP
bam-5830	176	25	the	the	DET
bam-5830	176	26	skeletal	skeletal	ADJ
bam-5830	176	27	muscle	muscle	NOUN
bam-5830	176	28	[	[	X
bam-5830	176	29	4	4	NUM
bam-5830	176	30	]	]	PUNCT
bam-5830	176	31	.	.	PUNCT
bam-5830	177	1	our	our	PRON
bam-5830	177	2	preliminary	preliminary	ADJ
bam-5830	177	3	results	result	NOUN
bam-5830	177	4	highlighted	highlight	VERB
bam-5830	177	5	defects	defect	NOUN
bam-5830	177	6	in	in	ADP
bam-5830	177	7	soleus	soleus	ADJ
bam-5830	177	8	muscle	muscle	NOUN
bam-5830	177	9	and	and	CCONJ
bam-5830	177	10	nmjs	nmj	NOUN
bam-5830	177	11	functionality	functionality	NOUN
bam-5830	177	12	in	in	ADP
bam-5830	177	13	mlc	mlc	PROPN
bam-5830	177	14	/	/	SYM
bam-5830	177	15	sod1g93a	sod1g93a	PROPN
bam-5830	177	16	mouse	mouse	PROPN
bam-5830	177	17	model	model	NOUN
bam-5830	177	18	,	,	PUNCT
bam-5830	177	19	compared	compare	VERB
bam-5830	177	20	to	to	ADP
bam-5830	177	21	the	the	DET
bam-5830	177	22	wild	wild	ADJ
bam-5830	177	23	type	type	NOUN
bam-5830	177	24	,	,	PUNCT
bam-5830	177	25	suggesting	suggest	VERB
bam-5830	177	26	a	a	DET
bam-5830	177	27	direct	direct	ADJ
bam-5830	177	28	muscle	muscle	NOUN
bam-5830	177	29	impairment	impairment	NOUN
bam-5830	177	30	.	.	PUNCT
bam-5830	178	1	further	further	ADJ
bam-5830	178	2	analysis	analysis	NOUN
bam-5830	178	3	on	on	ADP
bam-5830	178	4	this	this	DET
bam-5830	178	5	model	model	NOUN
bam-5830	178	6	will	will	AUX
bam-5830	178	7	provide	provide	VERB
bam-5830	178	8	useful	useful	ADJ
bam-5830	178	9	information	information	NOUN
bam-5830	178	10	about	about	ADP
bam-5830	178	11	the	the	DET
bam-5830	178	12	nmj	nmj	PROPN
bam-5830	178	13	alterations	alteration	NOUN
bam-5830	178	14	directly	directly	ADV
bam-5830	178	15	related	relate	VERB
bam-5830	178	16	to	to	PART
bam-5830	178	17	oxidative	oxidative	ADJ
bam-5830	178	18	stress	stress	NOUN
bam-5830	178	19	on	on	ADP
bam-5830	178	20	skeletal	skeletal	ADJ
bam-5830	178	21	muscles	muscle	NOUN
bam-5830	178	22	.	.	PUNCT
bam-5830	179	1	1	1	X
bam-5830	179	2	.	.	X
bam-5830	179	3	dupuis	dupuis	PROPN
bam-5830	179	4	l	l	PROPN
bam-5830	179	5	,	,	PUNCT
bam-5830	179	6	loefflerjp	loefflerjp	NOUN
bam-5830	179	7	.	.	PUNCT
bam-5830	180	1	neuromuscular	neuromuscular	ADJ
bam-5830	180	2	junction	junction	NOUN
bam-5830	180	3	destruction	destruction	NOUN
bam-5830	180	4	during	during	ADP
bam-5830	180	5	amyotrophic	amyotrophic	ADJ
bam-5830	180	6	lateral	lateral	ADJ
bam-5830	180	7	sclerosis	sclerosis	NOUN
bam-5830	180	8	:	:	PUNCT
bam-5830	180	9	insights	insight	NOUN
bam-5830	180	10	from	from	ADP
bam-5830	180	11	transgenic	transgenic	NOUN
bam-5830	180	12	models	model	NOUN
bam-5830	180	13	.	.	PUNCT
bam-5830	181	1	curr	curr	PROPN
bam-5830	181	2	opin	opin	PROPN
bam-5830	181	3	pharmacol	pharmacol	PROPN
bam-5830	181	4	.	.	PUNCT
bam-5830	182	1	2009	2009	NUM
bam-5830	182	2	jun;9(3):341	jun;9(3):341	PROPN
bam-5830	182	3	-	-	PUNCT
bam-5830	182	4	6	6	NUM
bam-5830	182	5	.	.	PUNCT
bam-5830	182	6	doi	doi	NOUN
bam-5830	182	7	:	:	PUNCT
bam-5830	182	8	10.1016	10.1016	NUM
bam-5830	182	9	/	/	SYM
bam-5830	182	10	j.coph.2009.03.007	j.coph.2009.03.007	PROPN
bam-5830	182	11	.	.	PUNCT
bam-5830	183	1	epub	epub	PROPN
bam-5830	183	2	2009	2009	NUM
bam-5830	183	3	apr	apr	NOUN
bam-5830	183	4	20	20	NUM
bam-5830	183	5	.	.	PUNCT
bam-5830	183	6	review	review	NOUN
bam-5830	183	7	.	.	PUNCT
bam-5830	184	1	2	2	X
bam-5830	184	2	.	.	X
bam-5830	184	3	e.	e.	PROPN
bam-5830	184	4	rizzuto	rizzuto	PROPN
bam-5830	184	5	,	,	PUNCT
bam-5830	184	6	s.	s.	PROPN
bam-5830	184	7	pisu	pisu	PROPN
bam-5830	184	8	,	,	PUNCT
bam-5830	184	9	a.	a.	NOUN
bam-5830	184	10	musarò	musarò	PROPN
bam-5830	184	11	,	,	PUNCT
bam-5830	184	12	z.	z.	PROPN
bam-5830	184	13	del	del	PROPN
bam-5830	184	14	prete	prete	PROPN
bam-5830	184	15	.	.	PUNCT
bam-5830	185	1	measuring	measure	VERB
bam-5830	185	2	neuromuscular	neuromuscular	ADJ
bam-5830	185	3	junction	junction	NOUN
bam-5830	185	4	functionality	functionality	NOUN
bam-5830	185	5	in	in	ADP
bam-5830	185	6	the	the	DET
bam-5830	185	7	sod1g93a	sod1g93a	PROPN
bam-5830	185	8	animal	animal	NOUN
bam-5830	185	9	model	model	NOUN
bam-5830	185	10	of	of	ADP
bam-5830	185	11	amyotrophic	amyotrophic	ADJ
bam-5830	185	12	lateral	lateral	ADJ
bam-5830	185	13	sclerosis	sclerosis	NOUN
bam-5830	185	14	.	.	PUNCT
bam-5830	186	1	ann	ann	PROPN
bam-5830	186	2	biomed	biome	VERB
bam-5830	186	3	eng	eng	PROPN
bam-5830	186	4	.	.	PROPN
bam-5830	186	5	2015	2015	NUM
bam-5830	186	6	sep;43(9):2196	sep;43(9):2196	PROPN
bam-5830	186	7	-	-	PUNCT
bam-5830	186	8	206	206	NUM
bam-5830	186	9	.	.	PUNCT
bam-5830	187	1	doi	doi	NOUN
bam-5830	187	2	:	:	PUNCT
bam-5830	187	3	10.1007	10.1007	NUM
bam-5830	187	4	/	/	SYM
bam-5830	187	5	s10439	s10439	NOUN
bam-5830	187	6	-	-	PUNCT
bam-5830	187	7	0151259	0151259	NUM
bam-5830	187	8	-	-	PUNCT
bam-5830	187	9	x.	x.	NOUN
bam-5830	187	10	epub	epub	PROPN
bam-5830	187	11	2015	2015	NUM
bam-5830	187	12	jan	jan	PROPN
bam-5830	187	13	29	29	NUM
bam-5830	187	14	.	.	PUNCT
bam-5830	188	1	3	3	X
bam-5830	188	2	.	.	X
bam-5830	188	3	mark	mark	PROPN
bam-5830	188	4	e.	e.	PROPN
bam-5830	188	5	gurney	gurney	PROPN
bam-5830	188	6	et	et	PROPN
bam-5830	188	7	al	al	PROPN
bam-5830	188	8	.	.	PROPN
bam-5830	188	9	motor	motor	PROPN
bam-5830	188	10	neuron	neuron	PROPN
bam-5830	188	11	degeneration	degeneration	NOUN
bam-5830	188	12	in	in	ADP
bam-5830	188	13	mice	mouse	NOUN
bam-5830	188	14	that	that	PRON
bam-5830	188	15	express	express	VERB
bam-5830	188	16	a	a	DET
bam-5830	188	17	human	human	PROPN
bam-5830	188	18	cu	cu	PROPN
bam-5830	188	19	,	,	PUNCT
bam-5830	188	20	zn	zn	PROPN
bam-5830	188	21	superoxide	superoxide	NOUN
bam-5830	188	22	dismutase	dismutase	NOUN
bam-5830	188	23	mutation	mutation	NOUN
bam-5830	188	24	.	.	PUNCT
bam-5830	189	1	science	science	NOUN
bam-5830	189	2	.	.	PUNCT
bam-5830	190	1	1994	1994	NUM
bam-5830	190	2	jun	jun	PROPN
bam-5830	190	3	17;264(5166):1772	17;264(5166):1772	NUM
bam-5830	190	4	-	-	SYM
bam-5830	190	5	5	5	NUM
bam-5830	190	6	.	.	NOUN
bam-5830	190	7	4	4	NUM
bam-5830	190	8	.	.	X
bam-5830	190	9	g.	g.	PROPN
bam-5830	190	10	dobrowolny	dobrowolny	PROPN
bam-5830	190	11	,	,	PUNCT
bam-5830	190	12	m.	m.	NOUN
bam-5830	190	13	aucello	aucello	PROPN
bam-5830	190	14	,	,	PUNCT
bam-5830	190	15	e.	e.	PROPN
bam-5830	190	16	rizzuto	rizzuto	PROPN
bam-5830	190	17	,	,	PUNCT
bam-5830	190	18	et	et	PROPN
bam-5830	190	19	al	al	PROPN
bam-5830	190	20	.	.	PROPN
bam-5830	191	1	skeletal	skeletal	ADJ
bam-5830	191	2	muscle	muscle	NOUN
bam-5830	191	3	is	be	AUX
bam-5830	191	4	a	a	DET
bam-5830	191	5	primary	primary	ADJ
bam-5830	191	6	target	target	NOUN
bam-5830	191	7	of	of	ADP
bam-5830	191	8	sod1g93a	sod1g93a	CCONJ
bam-5830	191	9	mediated	mediate	VERB
bam-5830	191	10	toxicity	toxicity	NOUN
bam-5830	191	11	cell	cell	NOUN
bam-5830	191	12	metab	metab	NOUN
bam-5830	191	13	2008;8:425	2008;8:425	NUM
bam-5830	191	14	-	-	SYM
bam-5830	191	15	36	36	NUM
bam-5830	191	16	.	.	PUNCT
bam-5830	192	1	doi	doi	NOUN
bam-5830	192	2	:	:	PUNCT
bam-5830	192	3	10.1016	10.1016	NUM
bam-5830	192	4	/	/	SYM
bam-5830	192	5	j.cmet.2008.09.002	j.cmet.2008.09.002	NOUN
bam-5830	192	6	.	.	PUNCT
bam-5830	193	1	*	*	PUNCT
bam-5830	193	2	*	*	PUNCT
bam-5830	193	3	*	*	PUNCT
bam-5830	193	4	*	*	PUNCT
bam-5830	193	5	*	*	PUNCT
bam-5830	193	6	design	design	NOUN
bam-5830	193	7	of	of	ADP
bam-5830	193	8	a	a	DET
bam-5830	193	9	high	high	ADJ
bam-5830	193	10	throughput	throughput	NOUN
bam-5830	193	11	screening	screening	NOUN
bam-5830	193	12	:	:	PUNCT
bam-5830	193	13	disrupt	disrupt	VERB
bam-5830	193	14	the	the	DET
bam-5830	193	15	super	super	ADV
bam-5830	193	16	relaxed	relaxed	ADJ
bam-5830	193	17	state	state	NOUN
bam-5830	193	18	of	of	ADP
bam-5830	193	19	myosin	myosin	NOUN
bam-5830	193	20	to	to	PART
bam-5830	193	21	cure	cure	VERB
bam-5830	193	22	obesity	obesity	NOUN
bam-5830	193	23	and	and	CCONJ
bam-5830	193	24	diabetes	diabetes	NOUN
bam-5830	193	25	l.	l.	PROPN
bam-5830	193	26	nogara	nogara	PROPN
bam-5830	193	27	1	1	NUM
bam-5830	193	28	,	,	PUNCT
bam-5830	193	29	n.	n.	PROPN
bam-5830	193	30	naber	naber	PROPN
bam-5830	193	31	2	2	NUM
bam-5830	193	32	,	,	PUNCT
bam-5830	193	33	e.	e.	PROPN
bam-5830	193	34	pate	pate	PROPN
bam-5830	193	35	3	3	NUM
bam-5830	193	36	,	,	PUNCT
bam-5830	193	37	m.	m.	PROPN
bam-5830	193	38	canton	canton	PROPN
bam-5830	193	39	1	1	NUM
bam-5830	193	40	,	,	PUNCT
bam-5830	193	41	r.	r.	PROPN
bam-5830	193	42	cooke	cooke	PROPN
bam-5830	193	43	2	2	NUM
bam-5830	193	44	,	,	PUNCT
bam-5830	193	45	c.	c.	PROPN
bam-5830	193	46	reggiani	reggiani	VERB
bam-5830	193	47	1	1	NUM
bam-5830	193	48	1	1	NUM
bam-5830	193	49	.	.	PUNCT
bam-5830	194	1	department	department	NOUN
bam-5830	194	2	of	of	ADP
bam-5830	194	3	biomedical	biomedical	ADJ
bam-5830	194	4	sciences	sciences	PROPN
bam-5830	194	5	,	,	PUNCT
bam-5830	194	6	university	university	NOUN
bam-5830	194	7	of	of	ADP
bam-5830	194	8	padova	padova	PROPN
bam-5830	194	9	,	,	PUNCT
bam-5830	194	10	italy	italy	PROPN
bam-5830	194	11	;	;	PUNCT
bam-5830	194	12	2	2	X
bam-5830	194	13	.	.	X
bam-5830	194	14	department	department	NOUN
bam-5830	194	15	of	of	ADP
bam-5830	194	16	biochemistry	biochemistry	NOUN
bam-5830	194	17	and	and	CCONJ
bam-5830	194	18	biophysics	biophysic	NOUN
bam-5830	194	19	,	,	PUNCT
bam-5830	194	20	university	university	PROPN
bam-5830	194	21	of	of	ADP
bam-5830	194	22	california	california	PROPN
bam-5830	194	23	,	,	PUNCT
bam-5830	194	24	san	san	PROPN
bam-5830	194	25	francisco	francisco	PROPN
bam-5830	194	26	,	,	PUNCT
bam-5830	194	27	ca	ca	PROPN
bam-5830	194	28	,	,	PUNCT
bam-5830	194	29	usa	usa	PROPN
bam-5830	194	30	;	;	PUNCT
bam-5830	194	31	3.voiland	3.voiland	NUM
bam-5830	194	32	school	school	NOUN
bam-5830	194	33	of	of	ADP
bam-5830	194	34	chemical	chemical	NOUN
bam-5830	194	35	engineering	engineering	NOUN
bam-5830	194	36	and	and	CCONJ
bam-5830	194	37	bioengineering	bioengineering	NOUN
bam-5830	194	38	,	,	PUNCT
bam-5830	194	39	washington	washington	PROPN
bam-5830	194	40	state	state	PROPN
bam-5830	194	41	university	university	PROPN
bam-5830	194	42	,	,	PUNCT
bam-5830	194	43	pullman	pullman	NOUN
bam-5830	194	44	,	,	PUNCT
bam-5830	194	45	wa	wa	PROPN
bam-5830	194	46	,	,	PUNCT
bam-5830	194	47	usa	usa	PROPN
bam-5830	194	48	;	;	PUNCT
bam-5830	194	49	e	e	X
bam-5830	194	50	-	-	NOUN
bam-5830	194	51	mail	mail	NOUN
bam-5830	194	52	:	:	PUNCT
bam-5830	194	53	leonardo.nogara@studenti.unipd.it	leonardo.nogara@studenti.unipd.it	PROPN
bam-5830	194	54	myosin	myosin	PROPN
bam-5830	194	55	is	be	AUX
bam-5830	194	56	an	an	DET
bam-5830	194	57	abundant	abundant	ADJ
bam-5830	194	58	atpase	atpase	ADJ
bam-5830	194	59	protein	protein	NOUN
bam-5830	194	60	.	.	PUNCT
bam-5830	195	1	it	it	PRON
bam-5830	195	2	is	be	AUX
bam-5830	195	3	estimated	estimate	VERB
bam-5830	195	4	that	that	SCONJ
bam-5830	195	5	10	10	NUM
bam-5830	195	6	%	%	NOUN
bam-5830	195	7	of	of	ADP
bam-5830	195	8	muscle	muscle	NOUN
bam-5830	195	9	tissue	tissue	NOUN
bam-5830	195	10	weight	weight	NOUN
bam-5830	195	11	is	be	AUX
bam-5830	195	12	myosin	myosin	NOUN
bam-5830	195	13	.	.	PUNCT
bam-5830	196	1	due	due	ADP
bam-5830	196	2	to	to	ADP
bam-5830	196	3	its	its	PRON
bam-5830	196	4	abundance	abundance	NOUN
bam-5830	196	5	,	,	PUNCT
bam-5830	196	6	myosin	myosin	PROPN
bam-5830	196	7	can	can	AUX
bam-5830	196	8	be	be	AUX
bam-5830	196	9	a	a	DET
bam-5830	196	10	good	good	ADJ
bam-5830	196	11	target	target	NOUN
bam-5830	196	12	to	to	PART
bam-5830	196	13	raise	raise	VERB
bam-5830	196	14	basal	basal	ADJ
bam-5830	196	15	metabolic	metabolic	NOUN
bam-5830	196	16	rate	rate	NOUN
bam-5830	196	17	in	in	ADP
bam-5830	196	18	animals	animal	NOUN
bam-5830	196	19	.	.	PUNCT
bam-5830	197	1	a	a	DET
bam-5830	197	2	new	new	ADJ
bam-5830	197	3	low	low	ADJ
bam-5830	197	4	-	-	PUNCT
bam-5830	197	5	atp	atp	NOUN
bam-5830	197	6	-	-	PUNCT
bam-5830	197	7	consumption	consumption	NOUN
bam-5830	197	8	state	state	NOUN
bam-5830	197	9	of	of	ADP
bam-5830	197	10	myosin	myosin	PROPN
bam-5830	197	11	has	have	AUX
bam-5830	197	12	recently	recently	ADV
bam-5830	197	13	been	be	AUX
bam-5830	197	14	proposed	propose	VERB
bam-5830	197	15	(	(	PUNCT
bam-5830	197	16	1	1	NUM
bam-5830	197	17	,	,	PUNCT
bam-5830	197	18	2	2	NUM
bam-5830	197	19	)	)	PUNCT
bam-5830	197	20	.	.	PUNCT
bam-5830	198	1	this	this	DET
bam-5830	198	2	new	new	ADJ
bam-5830	198	3	state	state	NOUN
bam-5830	198	4	has	have	AUX
bam-5830	198	5	been	be	AUX
bam-5830	198	6	called	call	VERB
bam-5830	198	7	the	the	DET
bam-5830	198	8	"	"	PUNCT
bam-5830	198	9	super	super	ADJ
bam-5830	198	10	relaxed	relaxed	ADJ
bam-5830	198	11	state	state	NOUN
bam-5830	198	12	(	(	PUNCT
bam-5830	198	13	srx	srx	NOUN
bam-5830	198	14	)	)	PUNCT
bam-5830	198	15	"	"	PUNCT
bam-5830	198	16	of	of	ADP
bam-5830	198	17	myosin	myosin	PROPN
bam-5830	198	18	.	.	PUNCT
bam-5830	199	1	structural	structural	ADJ
bam-5830	199	2	evidence	evidence	NOUN
bam-5830	199	3	for	for	ADP
bam-5830	199	4	the	the	DET
bam-5830	199	5	srx	srx	PROPN
bam-5830	199	6	state	state	NOUN
bam-5830	199	7	have	have	AUX
bam-5830	199	8	recently	recently	ADV
bam-5830	199	9	been	be	AUX
bam-5830	199	10	published	publish	VERB
bam-5830	199	11	showing	show	VERB
bam-5830	199	12	a	a	DET
bam-5830	199	13	close	close	ADJ
bam-5830	199	14	complex	complex	NOUN
bam-5830	199	15	formed	form	VERB
bam-5830	199	16	by	by	ADP
bam-5830	199	17	the	the	DET
bam-5830	199	18	twomyosin	twomyosin	NOUN
bam-5830	199	19	heads	head	NOUN
bam-5830	199	20	(	(	PUNCT
bam-5830	199	21	3	3	NUM
bam-5830	199	22	)	)	PUNCT
bam-5830	199	23	.	.	PUNCT
bam-5830	200	1	it	it	PRON
bam-5830	200	2	is	be	AUX
bam-5830	200	3	characterized	characterize	VERB
bam-5830	200	4	by	by	ADP
bam-5830	200	5	an	an	DET
bam-5830	200	6	atpase	atpase	PROPN
bam-5830	200	7	time	time	NOUN
bam-5830	200	8	constant	constant	ADJ
bam-5830	200	9	in	in	ADP
bam-5830	200	10	the	the	DET
bam-5830	200	11	order	order	NOUN
bam-5830	200	12	of	of	ADP
bam-5830	200	13	300	300	NUM
bam-5830	200	14	seconds	second	NOUN
bam-5830	200	15	versus	versus	ADP
bam-5830	200	16	the	the	DET
bam-5830	200	17	15	15	NUM
bam-5830	200	18	seconds	second	NOUN
bam-5830	200	19	for	for	ADP
bam-5830	200	20	the	the	DET
bam-5830	200	21	so	so	ADV
bam-5830	200	22	-	-	PUNCT
bam-5830	200	23	called	call	VERB
bam-5830	200	24	“	"	PUNCT
bam-5830	200	25	disordered	disordered	ADJ
bam-5830	200	26	relax	relax	NOUN
bam-5830	200	27	state	state	NOUN
bam-5830	200	28	"	"	PUNCT
bam-5830	200	29	(	(	PUNCT
bam-5830	200	30	drx)(1,2	drx)(1,2	NOUN
bam-5830	200	31	)	)	PUNCT
bam-5830	200	32	.	.	PUNCT
bam-5830	201	1	the	the	DET
bam-5830	201	2	idea	idea	NOUN
bam-5830	201	3	is	be	AUX
bam-5830	201	4	that	that	SCONJ
bam-5830	201	5	behind	behind	ADP
bam-5830	201	6	that	that	DET
bam-5830	201	7	large	large	ADJ
bam-5830	201	8	number	number	NOUN
bam-5830	201	9	of	of	ADP
bam-5830	201	10	"	"	PUNCT
bam-5830	201	11	dormant	dormant	ADJ
bam-5830	201	12	"	"	PUNCT
bam-5830	201	13	atpases	atpase	NOUN
bam-5830	201	14	,	,	PUNCT
bam-5830	201	15	there	there	PRON
bam-5830	201	16	is	be	VERB
bam-5830	201	17	the	the	DET
bam-5830	201	18	key	key	NOUN
bam-5830	201	19	to	to	PART
bam-5830	201	20	raise	raise	VERB
bam-5830	201	21	basal	basal	ADJ
bam-5830	201	22	metabolism	metabolism	NOUN
bam-5830	201	23	in	in	ADP
bam-5830	201	24	a	a	DET
bam-5830	201	25	physiological	physiological	ADJ
bam-5830	201	26	way	way	NOUN
bam-5830	201	27	.	.	PUNCT
bam-5830	202	1	the	the	DET
bam-5830	202	2	amount	amount	NOUN
bam-5830	202	3	of	of	ADP
bam-5830	202	4	myosin	myosin	NOUN
bam-5830	202	5	in	in	ADP
bam-5830	202	6	the	the	DET
bam-5830	202	7	srx	srx	PROPN
bam-5830	202	8	state	state	NOUN
bam-5830	202	9	is	be	AUX
bam-5830	202	10	estimated	estimate	VERB
bam-5830	202	11	to	to	PART
bam-5830	202	12	be	be	AUX
bam-5830	202	13	approximately	approximately	ADV
bam-5830	202	14	60	60	NUM
bam-5830	202	15	%	%	NOUN
bam-5830	202	16	of	of	ADP
bam-5830	202	17	the	the	DET
bam-5830	202	18	total	total	NOUN
bam-5830	202	19	.	.	PUNCT
bam-5830	203	1	switching	switch	VERB
bam-5830	203	2	of	of	ADP
bam-5830	203	3	the	the	DET
bam-5830	203	4	myosin	myosin	PROPN
bam-5830	203	5	heads	head	NOUN
bam-5830	203	6	from	from	ADP
bam-5830	203	7	the	the	DET
bam-5830	203	8	srx	srx	PROPN
bam-5830	203	9	state	state	NOUN
bam-5830	203	10	to	to	ADP
bam-5830	203	11	the	the	DET
bam-5830	203	12	drx	drx	PROPN
bam-5830	203	13	state	state	NOUN
bam-5830	203	14	is	be	AUX
bam-5830	203	15	regulated	regulate	VERB
bam-5830	203	16	by	by	ADP
bam-5830	203	17	phosphorylation	phosphorylation	NOUN
bam-5830	203	18	in	in	ADP
bam-5830	203	19	a	a	DET
bam-5830	203	20	cooperativeness	cooperativeness	NOUN
bam-5830	203	21	-	-	PUNCT
bam-5830	203	22	driven	drive	VERB
bam-5830	203	23	-	-	PUNCT
bam-5830	203	24	equilibrium	equilibrium	NOUN
bam-5830	203	25	.	.	PUNCT
bam-5830	204	1	controlling	control	VERB
bam-5830	204	2	this	this	DET
bam-5830	204	3	equilibrium	equilibrium	NOUN
bam-5830	204	4	may	may	AUX
bam-5830	204	5	lead	lead	VERB
bam-5830	204	6	to	to	ADP
bam-5830	204	7	an	an	DET
bam-5830	204	8	increase	increase	NOUN
bam-5830	204	9	in	in	ADP
bam-5830	204	10	basal	basal	ADJ
bam-5830	204	11	metabolism	metabolism	NOUN
bam-5830	204	12	that	that	PRON
bam-5830	204	13	would	would	AUX
bam-5830	204	14	consume	consume	VERB
bam-5830	204	15	an	an	DET
bam-5830	204	16	additional	additional	ADJ
bam-5830	204	17	energy	energy	NOUN
bam-5830	204	18	of	of	ADP
bam-5830	204	19	up	up	ADP
bam-5830	204	20	to	to	PART
bam-5830	204	21	1000	1000	NUM
bam-5830	204	22	kcal	kcal	NOUN
bam-5830	204	23	/	/	SYM
bam-5830	204	24	day	day	NOUN
bam-5830	204	25	.	.	PUNCT
bam-5830	205	1	we	we	PRON
bam-5830	205	2	studied	study	VERB
bam-5830	205	3	the	the	DET
bam-5830	205	4	effect	effect	NOUN
bam-5830	205	5	of	of	ADP
bam-5830	205	6	several	several	ADJ
bam-5830	205	7	regulatory	regulatory	ADJ
bam-5830	205	8	light	light	NOUN
bam-5830	205	9	chain	chain	NOUN
bam-5830	205	10	mutants	mutant	NOUN
bam-5830	205	11	on	on	ADP
bam-5830	205	12	the	the	DET
bam-5830	205	13	srx	srx	PROPN
bam-5830	205	14	state	state	NOUN
bam-5830	205	15	and	and	CCONJ
bam-5830	205	16	we	we	PRON
bam-5830	205	17	applied	apply	VERB
bam-5830	205	18	this	this	DET
bam-5830	205	19	information	information	NOUN
bam-5830	205	20	to	to	ADP
bam-5830	205	21	the	the	DET
bam-5830	205	22	development	development	NOUN
bam-5830	205	23	of	of	ADP
bam-5830	205	24	a	a	DET
bam-5830	205	25	high	high	ADJ
bam-5830	205	26	throughput	throughput	NOUN
bam-5830	205	27	screen	screen	NOUN
bam-5830	205	28	.	.	PUNCT
bam-5830	206	1	we	we	PRON
bam-5830	206	2	are	be	AUX
bam-5830	206	3	searching	search	VERB
bam-5830	206	4	a	a	DET
bam-5830	206	5	molecule	molecule	NOUN
bam-5830	206	6	that	that	PRON
bam-5830	206	7	is	be	AUX
bam-5830	206	8	able	able	ADJ
bam-5830	206	9	to	to	PART
bam-5830	206	10	destabilize	destabilize	VERB
bam-5830	206	11	the	the	DET
bam-5830	206	12	srx	srx	PROPN
bam-5830	206	13	state	state	NOUN
bam-5830	206	14	in	in	ADP
bam-5830	206	15	skeletal	skeletal	ADJ
bam-5830	206	16	muscle	muscle	NOUN
bam-5830	206	17	fibers	fiber	NOUN
bam-5830	206	18	.	.	PUNCT
bam-5830	207	1	we	we	PRON
bam-5830	207	2	screened	screen	VERB
bam-5830	207	3	2000	2000	NUM
bam-5830	207	4	compound	compound	NOUN
bam-5830	207	5	of	of	ADP
bam-5830	207	6	an	an	DET
bam-5830	207	7	fda	fda	PROPN
bam-5830	207	8	approved	approve	VERB
bam-5830	207	9	library	library	NOUN
bam-5830	207	10	.	.	PUNCT
bam-5830	208	1	potential	potential	ADJ
bam-5830	208	2	lead	lead	NOUN
bam-5830	208	3	compounds	compound	NOUN
bam-5830	208	4	will	will	AUX
bam-5830	208	5	be	be	AUX
bam-5830	208	6	discussed	discuss	VERB
bam-5830	208	7	1	1	NUM
bam-5830	208	8	.	.	PUNCT
bam-5830	209	1	cooke	cooke	PROPN
bam-5830	209	2	.	.	PUNCT
bam-5830	210	1	biophysical	biophysical	ADJ
bam-5830	210	2	reviews	review	NOUN
bam-5830	210	3	.	.	PUNCT
bam-5830	211	1	2011	2011	NUM
bam-5830	211	2	.	.	PUNCT
bam-5830	212	1	2	2	X
bam-5830	212	2	.	.	X
bam-5830	212	3	stewart	stewart	PROPN
bam-5830	212	4	et	et	PROPN
bam-5830	212	5	al	al	PROPN
bam-5830	212	6	.	.	PROPN
bam-5830	213	1	proc	proc	PROPN
bam-5830	213	2	natl	natl	PROPN
bam-5830	213	3	acad	acad	PROPN
bam-5830	213	4	sci	sci	PROPN
bam-5830	213	5	2010	2010	NUM
bam-5830	213	6	.	.	PUNCT
bam-5830	214	1	3	3	X
bam-5830	214	2	.	.	X
bam-5830	214	3	padrón	padrón	PROPN
bam-5830	214	4	et	et	PROPN
bam-5830	214	5	al	al	PROPN
bam-5830	214	6	.	.	PUNCT
bam-5830	215	1	j.	j.	PROPN
bam-5830	215	2	mol	mol	PROPN
bam-5830	215	3	.	.	PUNCT
bam-5830	216	1	biol	biol	PROPN
bam-5830	216	2	.	.	PUNCT
bam-5830	217	1	2008	2008	NUM
bam-5830	217	2	.	.	PUNCT
bam-5830	218	1	*	*	PUNCT
bam-5830	218	2	*	*	PUNCT
bam-5830	218	3	*	*	PUNCT
bam-5830	218	4	*	*	PUNCT
bam-5830	218	5	*	*	PUNCT
bam-5830	218	6	realization	realization	NOUN
bam-5830	218	7	of	of	ADP
bam-5830	218	8	a	a	DET
bam-5830	218	9	sarcomere	sarcomere	ADJ
bam-5830	218	10	-	-	PUNCT
bam-5830	218	11	like	like	ADJ
bam-5830	218	12	machine	machine	NOUN
bam-5830	218	13	based	base	VERB
bam-5830	218	14	on	on	ADP
bam-5830	218	15	muscle	muscle	NOUN
bam-5830	218	16	myosin	myosin	PROPN
bam-5830	218	17	p.	p.	PROPN
bam-5830	218	18	bianco	bianco	PROPN
bam-5830	218	19	1	1	NUM
bam-5830	218	20	,	,	PUNCT
bam-5830	218	21	l.	l.	PROPN
bam-5830	218	22	melli	melli	PROPN
bam-5830	218	23	1	1	NUM
bam-5830	218	24	,	,	PUNCT
bam-5830	218	25	g.	g.	PROPN
bam-5830	218	26	falorsi	falorsi	PROPN
bam-5830	218	27	1	1	NUM
bam-5830	218	28	,	,	PUNCT
bam-5830	218	29	i.	i.	PROPN
bam-5830	218	30	pertici	pertici	PROPN
bam-5830	218	31	1	1	NUM
bam-5830	218	32	,	,	PUNCT
bam-5830	218	33	g.	g.	PROPN
bam-5830	218	34	coceano	coceano	PROPN
bam-5830	218	35	2	2	NUM
bam-5830	218	36	,	,	PUNCT
bam-5830	218	37	d.	d.	PROPN
bam-5830	218	38	cojoc	cojoc	PROPN
bam-5830	218	39	2	2	NUM
bam-5830	218	40	,	,	PUNCT
bam-5830	218	41	v.	v.	ADP
bam-5830	218	42	lombardi	lombardi	PROPN
bam-5830	218	43	1	1	NUM
bam-5830	218	44	1	1	NUM
bam-5830	218	45	.	.	PUNCT
bam-5830	219	1	laboratory	laboratory	NOUN
bam-5830	219	2	of	of	ADP
bam-5830	219	3	physiology	physiology	NOUN
bam-5830	219	4	,	,	PUNCT
bam-5830	219	5	bio	bio	NOUN
bam-5830	219	6	,	,	PUNCT
bam-5830	219	7	university	university	NOUN
bam-5830	219	8	of	of	ADP
bam-5830	219	9	florence	florence	NOUN
bam-5830	219	10	,	,	PUNCT
bam-5830	219	11	italy	italy	PROPN
bam-5830	219	12	;	;	PUNCT
bam-5830	219	13	2	2	X
bam-5830	219	14	.	.	X
bam-5830	219	15	istituto	istituto	PROPN
bam-5830	219	16	officina	officina	PROPN
bam-5830	219	17	dei	dei	PROPN
bam-5830	219	18	materiali	materiali	PROPN
bam-5830	219	19	,	,	PUNCT
bam-5830	219	20	cnr	cnr	PROPN
bam-5830	219	21	,	,	PUNCT
bam-5830	219	22	triste	triste	NOUN
bam-5830	219	23	,	,	PUNCT
bam-5830	219	24	italy	italy	PROPN
bam-5830	219	25	.	.	PUNCT
bam-5830	220	1	e	e	X
bam-5830	220	2	-	-	NOUN
bam-5830	220	3	mail	mail	NOUN
bam-5830	220	4	:	:	PUNCT
bam-5830	220	5	pasquale.bianco@unifi.it	pasquale.bianco@unifi.it	VERB
bam-5830	220	6	the	the	DET
bam-5830	220	7	muscle	muscle	NOUN
bam-5830	220	8	cell	cell	NOUN
bam-5830	220	9	is	be	AUX
bam-5830	220	10	a	a	DET
bam-5830	220	11	biological	biological	ADJ
bam-5830	220	12	machine	machine	NOUN
bam-5830	220	13	where	where	SCONJ
bam-5830	220	14	steady	steady	ADJ
bam-5830	220	15	force	force	NOUN
bam-5830	220	16	and	and	CCONJ
bam-5830	220	17	shortening	shortening	NOUN
bam-5830	220	18	are	be	AUX
bam-5830	220	19	generated	generate	VERB
bam-5830	220	20	by	by	ADP
bam-5830	220	21	arrays	array	NOUN
bam-5830	220	22	of	of	ADP
bam-5830	220	23	the	the	DET
bam-5830	220	24	motor	motor	NOUN
bam-5830	220	25	protein	protein	NOUN
bam-5830	220	26	myosin	myosin	PROPN
bam-5830	220	27	ii	ii	PROPN
bam-5830	220	28	pulling	pull	VERB
bam-5830	220	29	the	the	DET
bam-5830	220	30	actin	actin	NOUN
bam-5830	220	31	filament	filament	NOUN
bam-5830	220	32	towards	towards	ADP
bam-5830	220	33	the	the	DET
bam-5830	220	34	centre	centre	NOUN
bam-5830	220	35	of	of	ADP
bam-5830	220	36	the	the	DET
bam-5830	220	37	sarcomere	sarcomere	NOUN
bam-5830	220	38	(	(	PUNCT
bam-5830	220	39	the	the	PRON
bam-5830	220	40	~2	~2	ADJ
bam-5830	220	41	μm	μm	NUM
bam-5830	220	42	long	long	ADJ
bam-5830	220	43	structural	structural	ADJ
bam-5830	220	44	unit	unit	NOUN
bam-5830	220	45	of	of	ADP
bam-5830	220	46	muscle	muscle	NOUN
bam-5830	220	47	)	)	PUNCT
bam-5830	220	48	during	during	ADP
bam-5830	220	49	cyclical	cyclical	ADJ
bam-5830	220	50	atp	atp	PROPN
bam-5830	220	51	-	-	PUNCT
bam-5830	220	52	driven	drive	VERB
bam-5830	220	53	interactions	interaction	NOUN
bam-5830	220	54	.	.	PUNCT
bam-5830	221	1	the	the	DET
bam-5830	221	2	fraction	fraction	NOUN
bam-5830	221	3	of	of	ADP
bam-5830	221	4	the	the	DET
bam-5830	221	5	time	time	NOUN
bam-5830	221	6	of	of	ADP
bam-5830	221	7	the	the	DET
bam-5830	221	8	atp	atp	NOUN
bam-5830	221	9	hydrolysis	hydrolysis	NOUN
bam-5830	221	10	cycle	cycle	NOUN
bam-5830	221	11	that	that	PRON
bam-5830	221	12	myosin	myosin	PROPN
bam-5830	221	13	ii	ii	PROPN
bam-5830	221	14	spends	spend	VERB
bam-5830	221	15	attached	attach	VERB
bam-5830	221	16	to	to	ADP
bam-5830	221	17	actin	actin	NOUN
bam-5830	221	18	depends	depend	VERB
bam-5830	221	19	on	on	ADP
bam-5830	221	20	the	the	DET
bam-5830	221	21	sarcomere	sarcomere	ADJ
bam-5830	221	22	load	load	NOUN
bam-5830	221	23	and	and	CCONJ
bam-5830	221	24	at	at	ADP
bam-5830	221	25	low	low	ADJ
bam-5830	221	26	load	load	NOUN
bam-5830	221	27	can	can	AUX
bam-5830	221	28	be	be	AUX
bam-5830	221	29	as	as	ADV
bam-5830	221	30	small	small	ADJ
bam-5830	221	31	as	as	ADP
bam-5830	221	32	0.02	0.02	NUM
bam-5830	221	33	.	.	PUNCT
bam-5830	222	1	the	the	DET
bam-5830	222	2	array	array	NOUN
bam-5830	222	3	-	-	PUNCT
bam-5830	222	4	type	type	NOUN
bam-5830	222	5	arrangement	arrangement	NOUN
bam-5830	222	6	of	of	ADP
bam-5830	222	7	the	the	DET
bam-5830	222	8	motors	motor	NOUN
bam-5830	222	9	enhances	enhance	NOUN
bam-5830	222	10	and	and	CCONJ
bam-5830	222	11	makes	make	VERB
bam-5830	222	12	steady	steady	ADJ
bam-5830	222	13	the	the	DET
bam-5830	222	14	production	production	NOUN
bam-5830	222	15	of	of	ADP
bam-5830	222	16	force	force	NOUN
bam-5830	222	17	and	and	CCONJ
bam-5830	222	18	shortening	shortening	NOUN
bam-5830	222	19	,	,	PUNCT
bam-5830	222	20	but	but	CCONJ
bam-5830	222	21	has	have	AUX
bam-5830	222	22	so	so	ADV
bam-5830	222	23	far	far	ADV
bam-5830	222	24	limited	limit	VERB
bam-5830	222	25	the	the	DET
bam-5830	222	26	investigation	investigation	NOUN
bam-5830	222	27	of	of	ADP
bam-5830	222	28	mechanics	mechanic	NOUN
bam-5830	222	29	,	,	PUNCT
bam-5830	222	30	energetics	energetic	NOUN
bam-5830	222	31	and	and	CCONJ
bam-5830	222	32	structural	structural	ADJ
bam-5830	222	33	dynamics	dynamic	NOUN
bam-5830	222	34	of	of	ADP
bam-5830	222	35	this	this	DET
bam-5830	222	36	collective	collective	ADJ
bam-5830	222	37	motor	motor	NOUN
bam-5830	222	38	to	to	ADP
bam-5830	222	39	top	top	VERB
bam-5830	222	40	-	-	PUNCT
bam-5830	222	41	down	down	ADP
bam-5830	222	42	approaches	approach	NOUN
bam-5830	222	43	,	,	PUNCT
bam-5830	222	44	such	such	ADJ
bam-5830	222	45	as	as	ADP
bam-5830	222	46	single	single	ADJ
bam-5830	222	47	-	-	PUNCT
bam-5830	222	48	cell	cell	NOUN
bam-5830	222	49	mechanics	mechanic	NOUN
bam-5830	222	50	and	and	CCONJ
bam-5830	222	51	x	x	NOUN
bam-5830	222	52	-	-	NOUN
bam-5830	222	53	ray	ray	NOUN
bam-5830	222	54	diffraction	diffraction	NOUN
bam-5830	222	55	(	(	PUNCT
bam-5830	222	56	piazzesi	piazzesi	NOUN
bam-5830	222	57	et	et	PROPN
bam-5830	222	58	al	al	PROPN
bam-5830	222	59	.	.	PROPN
bam-5830	222	60	cell	cell	PROPN
bam-5830	222	61	131:784	131:784	NUM
bam-5830	222	62	-	-	SYM
bam-5830	222	63	795	795	NUM
bam-5830	222	64	,	,	PUNCT
bam-5830	222	65	2007	2007	NUM
bam-5830	222	66	)	)	PUNCT
bam-5830	222	67	.	.	PUNCT
bam-5830	223	1	the	the	DET
bam-5830	223	2	laser	laser	NOUN
bam-5830	223	3	trap	trap	NOUN
bam-5830	223	4	technique	technique	NOUN
bam-5830	223	5	in	in	ADP
bam-5830	223	6	the	the	DET
bam-5830	223	7	three	three	NUM
bam-5830	223	8	bead	bead	NOUN
bam-5830	223	9	assay	assay	NOUN
bam-5830	223	10	(	(	PUNCT
bam-5830	223	11	tba	tba	NOUN
bam-5830	223	12	)	)	PUNCT
bam-5830	223	13	configuration	configuration	NOUN
bam-5830	223	14	allowed	allow	VERB
bam-5830	223	15	the	the	DET
bam-5830	223	16	recording	recording	NOUN
bam-5830	223	17	of	of	ADP
bam-5830	223	18	single	single	ADJ
bam-5830	223	19	actin	actin	NOUN
bam-5830	223	20	-	-	PUNCT
bam-5830	223	21	myosin	myosin	NOUN
bam-5830	223	22	interaction	interaction	NOUN
bam-5830	223	23	in	in	ADP
bam-5830	223	24	vitro	vitro	NOUN
bam-5830	223	25	,	,	PUNCT
bam-5830	223	26	but	but	CCONJ
bam-5830	223	27	only	only	ADV
bam-5830	223	28	when	when	SCONJ
bam-5830	223	29	the	the	DET
bam-5830	223	30	duration	duration	NOUN
bam-5830	223	31	of	of	ADP
bam-5830	223	32	attachment	attachment	NOUN
bam-5830	223	33	was	be	AUX
bam-5830	223	34	increased	increase	VERB
bam-5830	223	35	by	by	ADP
bam-5830	223	36	reducing	reduce	VERB
bam-5830	223	37	the	the	DET
bam-5830	223	38	atp	atp	NOUN
bam-5830	223	39	concentration	concentration	NOUN
bam-5830	223	40	to	to	ADP
bam-5830	223	41	a	a	DET
bam-5830	223	42	few	few	ADJ
bam-5830	223	43	tens	ten	NOUN
bam-5830	223	44	of	of	ADP
bam-5830	223	45	micromolar	micromolar	ADJ
bam-5830	223	46	(	(	PUNCT
bam-5830	223	47	two	two	NUM
bam-5830	223	48	orders	order	NOUN
bam-5830	223	49	of	of	ADP
bam-5830	223	50	magnitude	magnitude	NOUN
bam-5830	223	51	lower	low	ADJ
bam-5830	223	52	than	than	ADP
bam-5830	223	53	that	that	PRON
bam-5830	223	54	in	in	ADP
bam-5830	223	55	situ	situ	NOUN
bam-5830	223	56	in	in	ADP
bam-5830	223	57	physiological	physiological	ADJ
bam-5830	223	58	conditions	condition	NOUN
bam-5830	223	59	)	)	PUNCT
bam-5830	223	60	.	.	PUNCT
bam-5830	224	1	in	in	ADP
bam-5830	224	2	this	this	DET
bam-5830	224	3	project	project	NOUN
bam-5830	224	4	we	we	PRON
bam-5830	224	5	use	use	VERB
bam-5830	224	6	an	an	DET
bam-5830	224	7	alternative	alternative	ADJ
bam-5830	224	8	approach	approach	NOUN
bam-5830	224	9	consisting	consist	VERB
bam-5830	224	10	in	in	ADP
bam-5830	224	11	assembling	assemble	VERB
bam-5830	224	12	molecular	molecular	ADJ
bam-5830	224	13	motor	motor	NOUN
bam-5830	224	14	proteins	protein	NOUN
bam-5830	224	15	on	on	ADP
bam-5830	224	16	a	a	DET
bam-5830	224	17	nanostructured	nanostructure	VERB
bam-5830	224	18	support	support	NOUN
bam-5830	224	19	to	to	PART
bam-5830	224	20	generate	generate	VERB
bam-5830	224	21	a	a	DET
bam-5830	224	22	synthetic	synthetic	ADJ
bam-5830	224	23	sarcomerescale	sarcomerescale	NOUN
bam-5830	224	24	machine	machine	NOUN
bam-5830	224	25	,	,	PUNCT
bam-5830	224	26	the	the	DET
bam-5830	224	27	mechanical	mechanical	ADJ
bam-5830	224	28	output	output	NOUN
bam-5830	224	29	of	of	ADP
bam-5830	224	30	which	which	PRON
bam-5830	224	31	is	be	AUX
bam-5830	224	32	measured	measure	VERB
bam-5830	224	33	with	with	ADP
bam-5830	224	34	a	a	DET
bam-5830	224	35	double	double	ADJ
bam-5830	224	36	laser	laser	NOUN
bam-5830	224	37	optical	optical	ADJ
bam-5830	224	38	tweezers	tweezer	NOUN
bam-5830	224	39	apparatus	apparatus	NOUN
bam-5830	224	40	(	(	PUNCT
bam-5830	224	41	bianco	bianco	PROPN
bam-5830	224	42	et	et	PROPN
bam-5830	224	43	al	al	PROPN
bam-5830	224	44	.	.	PROPN
bam-5830	224	45	biophys	biophys	PROPN
bam-5830	224	46	.	.	PUNCT
bam-5830	225	1	j.	j.	PROPN
bam-5830	225	2	101:866	101:866	PROPN
bam-5830	225	3	-	-	PUNCT
bam-5830	225	4	874	874	NUM
bam-5830	225	5	,	,	PUNCT
bam-5830	225	6	2011	2011	NUM
bam-5830	225	7	)	)	PUNCT
bam-5830	225	8	.	.	PUNCT
bam-5830	226	1	the	the	DET
bam-5830	226	2	shape	shape	NOUN
bam-5830	226	3	,	,	PUNCT
bam-5830	226	4	the	the	DET
bam-5830	226	5	material	material	NOUN
bam-5830	226	6	and	and	CCONJ
bam-5830	226	7	the	the	DET
bam-5830	226	8	coating	coating	NOUN
bam-5830	226	9	of	of	ADP
bam-5830	226	10	the	the	DET
bam-5830	226	11	support	support	NOUN
bam-5830	226	12	carrying	carry	VERB
bam-5830	226	13	the	the	DET
bam-5830	226	14	motor	motor	NOUN
bam-5830	226	15	array	array	NOUN
bam-5830	226	16	have	have	AUX
bam-5830	226	17	been	be	AUX
bam-5830	226	18	optimised	optimise	VERB
bam-5830	226	19	using	use	VERB
bam-5830	226	20	a	a	DET
bam-5830	226	21	preliminary	preliminary	ADJ
bam-5830	226	22	version	version	NOUN
bam-5830	226	23	of	of	ADP
bam-5830	226	24	the	the	DET
bam-5830	226	25	machine	machine	NOUN
bam-5830	226	26	consisting	consist	VERB
bam-5830	226	27	of	of	ADP
bam-5830	226	28	an	an	DET
bam-5830	226	29	ensemble	ensemble	NOUN
bam-5830	226	30	of	of	ADP
bam-5830	226	31	motor	motor	NOUN
bam-5830	226	32	proteins	protein	NOUN
bam-5830	226	33	randomly	randomly	ADV
bam-5830	226	34	adsorbed	adsorb	VERB
bam-5830	226	35	on	on	ADP
bam-5830	226	36	a	a	DET
bam-5830	226	37	flat	flat	ADJ
bam-5830	226	38	surface	surface	NOUN
bam-5830	226	39	and	and	CCONJ
bam-5830	226	40	brought	bring	VERB
bam-5830	226	41	to	to	PART
bam-5830	226	42	interact	interact	VERB
bam-5830	226	43	with	with	ADP
bam-5830	226	44	an	an	DET
bam-5830	226	45	actin	actin	NOUN
bam-5830	226	46	filament	filament	NOUN
bam-5830	226	47	attached	attach	VERB
bam-5830	226	48	to	to	ADP
bam-5830	226	49	the	the	DET
bam-5830	226	50	trapped	trap	VERB
bam-5830	226	51	bead	bead	NOUN
bam-5830	226	52	with	with	ADP
bam-5830	226	53	the	the	DET
bam-5830	226	54	correct	correct	ADJ
bam-5830	226	55	polarity	polarity	NOUN
bam-5830	226	56	.	.	PUNCT
bam-5830	227	1	tests	test	NOUN
bam-5830	227	2	on	on	ADP
bam-5830	227	3	the	the	DET
bam-5830	227	4	density	density	NOUN
bam-5830	227	5	and	and	CCONJ
bam-5830	227	6	the	the	DET
bam-5830	227	7	disposition	disposition	NOUN
bam-5830	227	8	of	of	ADP
bam-5830	227	9	the	the	DET
bam-5830	227	10	myosin	myosin	PROPN
bam-5830	227	11	motors	motor	NOUN
bam-5830	227	12	on	on	ADP
bam-5830	227	13	the	the	DET
bam-5830	227	14	surface	surface	NOUN
bam-5830	227	15	have	have	AUX
bam-5830	227	16	been	be	AUX
bam-5830	227	17	done	do	VERB
bam-5830	227	18	using	use	VERB
bam-5830	227	19	afm	afm	PROPN
bam-5830	227	20	.	.	PUNCT
bam-5830	228	1	the	the	DET
bam-5830	228	2	most	most	ADV
bam-5830	228	3	reproducible	reproducible	ADJ
bam-5830	228	4	results	result	NOUN
bam-5830	228	5	have	have	AUX
bam-5830	228	6	been	be	AUX
bam-5830	228	7	obtained	obtain	VERB
bam-5830	228	8	when	when	SCONJ
bam-5830	228	9	the	the	DET
bam-5830	228	10	support	support	NOUN
bam-5830	228	11	for	for	ADP
bam-5830	228	12	the	the	DET
bam-5830	228	13	motor	motor	NOUN
bam-5830	228	14	ensemble	ensemble	ADJ
bam-5830	228	15	is	be	AUX
bam-5830	228	16	the	the	DET
bam-5830	228	17	lateral	lateral	ADJ
bam-5830	228	18	surface	surface	NOUN
bam-5830	228	19	of	of	ADP
bam-5830	228	20	a	a	DET
bam-5830	228	21	chemically	chemically	ADV
bam-5830	228	22	etched	etch	VERB
bam-5830	228	23	single	single	ADJ
bam-5830	228	24	mode	mode	NOUN
bam-5830	228	25	optical	optical	ADJ
bam-5830	228	26	fibre	fibre	NOUN
bam-5830	228	27	(	(	PUNCT
bam-5830	228	28	diameter	diameter	NOUN
bam-5830	228	29	4	4	NUM
bam-5830	228	30	µm	µm	NOUN
bam-5830	228	31	)	)	PUNCT
bam-5830	228	32	.	.	PUNCT
bam-5830	229	1	in	in	ADP
bam-5830	229	2	solution	solution	NOUN
bam-5830	229	3	with	with	ADP
bam-5830	229	4	physiological	physiological	ADJ
bam-5830	229	5	[	[	X
bam-5830	229	6	atp	atp	X
bam-5830	229	7	]	]	X
bam-5830	229	8	(	(	PUNCT
bam-5830	229	9	2	2	NUM
bam-5830	229	10	mm	mm	NOUN
bam-5830	229	11	)	)	PUNCT
bam-5830	229	12	,	,	PUNCT
bam-5830	229	13	the	the	DET
bam-5830	229	14	ensemble	ensemble	ADJ
bam-5830	229	15	drives	drive	VERB
bam-5830	229	16	350	350	NUM
bam-5830	229	17	nm	nm	NOUN
bam-5830	229	18	of	of	ADP
bam-5830	229	19	actin	actin	NOUN
bam-5830	229	20	filament	filament	NOUN
bam-5830	229	21	sliding	slide	VERB
bam-5830	229	22	developing	develop	VERB
bam-5830	229	23	a	a	DET
bam-5830	229	24	steady	steady	ADJ
bam-5830	229	25	force	force	NOUN
bam-5830	229	26	of	of	ADP
bam-5830	229	27	50	50	NUM
bam-5830	229	28	pn	pn	NOUN
bam-5830	229	29	.	.	PUNCT
bam-5830	230	1	abstracts	abstract	NOUN
bam-5830	230	2	of	of	ADP
bam-5830	230	3	the	the	DET
bam-5830	230	4	xii	xii	PROPN
bam-5830	230	5	iim	iim	NOUN
bam-5830	230	6	myology	myology	NOUN
bam-5830	230	7	meeting	meeting	NOUN
bam-5830	230	8	october	october	PROPN
bam-5830	230	9	1–4	1–4	PROPN
bam-5830	230	10	,	,	PUNCT
bam-5830	230	11	2015	2015	NUM
bam-5830	230	12	eur	eur	PROPN
bam-5830	230	13	j	j	PROPN
bam-5830	230	14	transl	transl	PROPN
bam-5830	230	15	myol	myol	PROPN
bam-5830	230	16	basic	basic	ADJ
bam-5830	230	17	appl	appl	NOUN
bam-5830	230	18	myol	myol	NOUN
bam-5830	230	19	2016	2016	NUM
bam-5830	230	20	;	;	PUNCT
bam-5830	230	21	26	26	NUM
bam-5830	230	22	(	(	PUNCT
bam-5830	230	23	1):2	1):2	NUM
bam-5830	230	24	-	-	SYM
bam-5830	230	25	24	24	NUM
bam-5830	230	26	this	this	DET
bam-5830	230	27	article	article	NOUN
bam-5830	230	28	is	be	AUX
bam-5830	230	29	distributed	distribute	VERB
bam-5830	230	30	under	under	ADP
bam-5830	230	31	the	the	DET
bam-5830	230	32	terms	term	NOUN
bam-5830	230	33	of	of	ADP
bam-5830	230	34	the	the	DET
bam-5830	230	35	creative	creative	ADJ
bam-5830	230	36	commons	common	NOUN
bam-5830	230	37	attribution	attribution	NOUN
bam-5830	230	38	noncommercial	noncommercial	ADJ
bam-5830	230	39	license	license	NOUN
bam-5830	230	40	(	(	PUNCT
bam-5830	230	41	cc	cc	NOUN
bam-5830	230	42	by	by	ADP
bam-5830	230	43	-	-	PUNCT
bam-5830	230	44	nc	nc	PROPN
bam-5830	230	45	4.0	4.0	NUM
bam-5830	230	46	)	)	PUNCT
bam-5830	230	47	which	which	PRON
bam-5830	230	48	permits	permit	VERB
bam-5830	230	49	any	any	DET
bam-5830	230	50	noncommercial	noncommercial	ADJ
bam-5830	230	51	use	use	NOUN
bam-5830	230	52	,	,	PUNCT
bam-5830	230	53	distribution	distribution	NOUN
bam-5830	230	54	,	,	PUNCT
bam-5830	230	55	and	and	CCONJ
bam-5830	230	56	reproduction	reproduction	NOUN
bam-5830	230	57	in	in	ADP
bam-5830	230	58	any	any	DET
bam-5830	230	59	medium	medium	NOUN
bam-5830	230	60	,	,	PUNCT
bam-5830	230	61	provided	provide	VERB
bam-5830	230	62	the	the	DET
bam-5830	230	63	original	original	ADJ
bam-5830	230	64	author(s	author(s	NOUN
bam-5830	230	65	)	)	PUNCT
bam-5830	230	66	and	and	CCONJ
bam-5830	230	67	source	source	NOUN
bam-5830	230	68	are	be	AUX
bam-5830	230	69	credited	credit	VERB
bam-5830	230	70	.	.	PUNCT
bam-5830	231	1	9	9	NUM
bam-5830	231	2	supported	support	VERB
bam-5830	231	3	by	by	ADP
bam-5830	231	4	italian	italian	PROPN
bam-5830	231	5	institute	institute	PROPN
bam-5830	231	6	of	of	ADP
bam-5830	231	7	technology	technology	NOUN
bam-5830	231	8	-	-	PUNCT
bam-5830	231	9	seed	seed	NOUN
bam-5830	231	10	,	,	PUNCT
bam-5830	231	11	project	project	NOUN
bam-5830	231	12	myomac	myomac	NOUN
bam-5830	231	13	(	(	PUNCT
bam-5830	231	14	genova	genova	PROPN
bam-5830	231	15	)	)	PUNCT
bam-5830	231	16	and	and	CCONJ
bam-5830	231	17	prin	prin	NOUN
bam-5830	231	18	-	-	PUNCT
bam-5830	231	19	miur	miur	PROPN
bam-5830	231	20	,	,	PUNCT
bam-5830	231	21	italy	italy	PROPN
bam-5830	231	22	.	.	PUNCT
bam-5830	232	1	*	*	PUNCT
bam-5830	233	1	*	*	PUNCT
bam-5830	233	2	*	*	PUNCT
bam-5830	233	3	*	*	PUNCT
bam-5830	233	4	*	*	PUNCT
bam-5830	233	5	*	*	PUNCT
bam-5830	233	6	*	*	PUNCT
bam-5830	233	7	*	*	PUNCT
bam-5830	233	8	*	*	PUNCT
bam-5830	233	9	*	*	PUNCT
bam-5830	233	10	*	*	PUNCT
bam-5830	233	11	*	*	PUNCT
bam-5830	233	12	*	*	PUNCT
bam-5830	233	13	*	*	PUNCT
bam-5830	233	14	*	*	PUNCT
bam-5830	233	15	session	session	NOUN
bam-5830	233	16	3	3	X
bam-5830	233	17	.	.	PUNCT
bam-5830	233	18	muscle	muscle	NOUN
bam-5830	233	19	wasting	waste	VERB
bam-5830	233	20	and	and	CCONJ
bam-5830	233	21	cachexia	cachexia	NOUN
bam-5830	233	22	involvement	involvement	NOUN
bam-5830	233	23	of	of	ADP
bam-5830	233	24	s1p/	s1p/	PROPN
bam-5830	233	25	s1pr	s1pr	PUNCT
bam-5830	233	26	axis	axis	ADJ
bam-5830	233	27	in	in	ADP
bam-5830	233	28	skeletal	skeletal	ADJ
bam-5830	233	29	muscle	muscle	NOUN
bam-5830	233	30	atrophy	atrophy	NOUN
bam-5830	233	31	f.	f.	PROPN
bam-5830	233	32	pierucci	pierucci	PROPN
bam-5830	233	33	1	1	NUM
bam-5830	233	34	,	,	PUNCT
bam-5830	233	35	a.	a.	NOUN
bam-5830	233	36	frati	frati	NOUN
bam-5830	233	37	1	1	NUM
bam-5830	233	38	,	,	PUNCT
bam-5830	233	39	c.	c.	PROPN
bam-5830	233	40	battistini	battistini	PROPN
bam-5830	233	41	1	1	NUM
bam-5830	233	42	,	,	PUNCT
bam-5830	233	43	e.	e.	PROPN
bam-5830	233	44	bruzzone	bruzzone	PROPN
bam-5830	234	1	1	1	NUM
bam-5830	234	2	,	,	PUNCT
bam-5830	234	3	f.	f.	PROPN
bam-5830	234	4	matteini	matteini	PROPN
bam-5830	234	5	1	1	NUM
bam-5830	234	6	,	,	PUNCT
bam-5830	234	7	f.	f.	PROPN
bam-5830	234	8	penna	penna	PROPN
bam-5830	234	9	2	2	NUM
bam-5830	234	10	,	,	PUNCT
bam-5830	234	11	p.	p.	NOUN
bam-5830	234	12	costelli	costelli	PROPN
bam-5830	234	13	2	2	NUM
bam-5830	234	14	,	,	PUNCT
bam-5830	235	1	e.	e.	PROPN
bam-5830	235	2	meacci	meacci	PROPN
bam-5830	235	3	1	1	NUM
bam-5830	235	4	1	1	X
bam-5830	235	5	.	.	PUNCT
bam-5830	236	1	department	department	NOUN
bam-5830	236	2	of	of	ADP
bam-5830	236	3	biochemical	biochemical	ADJ
bam-5830	236	4	sciences	science	NOUN
bam-5830	236	5	,	,	PUNCT
bam-5830	236	6	university	university	NOUN
bam-5830	236	7	of	of	ADP
bam-5830	236	8	florence	florence	NOUN
bam-5830	236	9	,	,	PUNCT
bam-5830	236	10	italy	italy	PROPN
bam-5830	236	11	;	;	PUNCT
bam-5830	236	12	2	2	X
bam-5830	236	13	.	.	X
bam-5830	236	14	department	department	NOUN
bam-5830	236	15	of	of	ADP
bam-5830	236	16	experimental	experimental	ADJ
bam-5830	236	17	medicine	medicine	NOUN
bam-5830	236	18	and	and	CCONJ
bam-5830	236	19	oncology	oncology	NOUN
bam-5830	236	20	,	,	PUNCT
bam-5830	236	21	university	university	PROPN
bam-5830	236	22	of	of	ADP
bam-5830	236	23	turin	turin	PROPN
bam-5830	236	24	,	,	PUNCT
bam-5830	236	25	italy	italy	PROPN
bam-5830	236	26	e	e	PROPN
bam-5830	236	27	-	-	NOUN
bam-5830	236	28	mail	mail	NOUN
bam-5830	236	29	:	:	PUNCT
bam-5830	236	30	federica.pierucci@unifi.it	federica.pierucci@unifi.it	ADJ
bam-5830	236	31	skeletal	skeletal	ADJ
bam-5830	236	32	muscle	muscle	NOUN
bam-5830	236	33	atrophy	atrophy	NOUN
bam-5830	236	34	is	be	AUX
bam-5830	236	35	caused	cause	VERB
bam-5830	236	36	by	by	ADP
bam-5830	236	37	several	several	ADJ
bam-5830	236	38	and	and	CCONJ
bam-5830	236	39	heterogeneous	heterogeneous	ADJ
bam-5830	236	40	conditions	condition	NOUN
bam-5830	236	41	,	,	PUNCT
bam-5830	236	42	such	such	ADJ
bam-5830	236	43	as	as	ADP
bam-5830	236	44	cancer	cancer	NOUN
bam-5830	236	45	(	(	PUNCT
bam-5830	236	46	cachexia	cachexia	PROPN
bam-5830	236	47	)	)	PUNCT
bam-5830	236	48	,	,	PUNCT
bam-5830	236	49	neuromuscular	neuromuscular	ADJ
bam-5830	236	50	disorders	disorder	NOUN
bam-5830	236	51	and	and	CCONJ
bam-5830	236	52	aging	aging	NOUN
bam-5830	236	53	.	.	PUNCT
bam-5830	237	1	in	in	ADP
bam-5830	237	2	most	most	ADJ
bam-5830	237	3	types	type	NOUN
bam-5830	237	4	of	of	ADP
bam-5830	237	5	skeletal	skeletal	ADJ
bam-5830	237	6	muscle	muscle	NOUN
bam-5830	237	7	atrophy	atrophy	NOUN
bam-5830	237	8	overall	overall	ADJ
bam-5830	237	9	rates	rate	NOUN
bam-5830	237	10	of	of	ADP
bam-5830	237	11	protein	protein	NOUN
bam-5830	237	12	synthesis	synthesis	NOUN
bam-5830	237	13	are	be	AUX
bam-5830	237	14	suppressed	suppress	VERB
bam-5830	237	15	,	,	PUNCT
bam-5830	237	16	protein	protein	NOUN
bam-5830	237	17	degradation	degradation	NOUN
bam-5830	237	18	is	be	AUX
bam-5830	237	19	consistently	consistently	ADV
bam-5830	237	20	elevated	elevated	ADJ
bam-5830	237	21	and	and	CCONJ
bam-5830	237	22	atrogenes	atrogene	NOUN
bam-5830	237	23	,	,	PUNCT
bam-5830	237	24	such	such	ADJ
bam-5830	237	25	as	as	ADP
bam-5830	237	26	the	the	DET
bam-5830	237	27	ubiquitin	ubiquitin	NOUN
bam-5830	237	28	ligase	ligase	NOUN
bam-5830	237	29	atrogin-1	atrogin-1	PROPN
bam-5830	237	30	/	/	SYM
bam-5830	237	31	mafbx	mafbx	NOUN
bam-5830	237	32	,	,	PUNCT
bam-5830	237	33	are	be	AUX
bam-5830	237	34	up	up	ADV
bam-5830	237	35	-	-	PUNCT
bam-5830	237	36	regulated	regulate	VERB
bam-5830	237	37	.	.	PUNCT
bam-5830	238	1	sphingolipids	sphingolipid	NOUN
bam-5830	238	2	represent	represent	VERB
bam-5830	238	3	a	a	DET
bam-5830	238	4	class	class	NOUN
bam-5830	238	5	of	of	ADP
bam-5830	238	6	bioactive	bioactive	ADJ
bam-5830	238	7	molecules	molecule	NOUN
bam-5830	238	8	capable	capable	ADJ
bam-5830	238	9	of	of	ADP
bam-5830	238	10	modulating	modulate	VERB
bam-5830	238	11	the	the	DET
bam-5830	238	12	destiny	destiny	NOUN
bam-5830	238	13	of	of	ADP
bam-5830	238	14	many	many	ADJ
bam-5830	238	15	cell	cell	NOUN
bam-5830	238	16	types	type	NOUN
bam-5830	238	17	,	,	PUNCT
bam-5830	238	18	including	include	VERB
bam-5830	238	19	skeletal	skeletal	ADJ
bam-5830	238	20	muscle	muscle	NOUN
bam-5830	238	21	cells	cell	NOUN
bam-5830	238	22	.	.	PUNCT
bam-5830	239	1	in	in	ADP
bam-5830	239	2	particular	particular	ADJ
bam-5830	239	3	,	,	PUNCT
bam-5830	239	4	we	we	PRON
bam-5830	239	5	and	and	CCONJ
bam-5830	239	6	others	other	NOUN
bam-5830	239	7	have	have	AUX
bam-5830	239	8	shown	show	VERB
bam-5830	239	9	that	that	SCONJ
bam-5830	239	10	sphingosine	sphingosine	NOUN
bam-5830	239	11	1	1	NUM
bam-5830	239	12	-	-	NOUN
bam-5830	239	13	phosphate	phosphate	NOUN
bam-5830	239	14	(	(	PUNCT
bam-5830	239	15	s1p	s1p	PROPN
bam-5830	239	16	)	)	PUNCT
bam-5830	239	17	,	,	PUNCT
bam-5830	239	18	formed	form	VERB
bam-5830	239	19	by	by	ADP
bam-5830	239	20	sphingosine	sphingosine	PROPN
bam-5830	239	21	kinase	kinase	PROPN
bam-5830	239	22	(	(	PUNCT
bam-5830	239	23	sphk	sphk	PROPN
bam-5830	239	24	)	)	PUNCT
bam-5830	239	25	,	,	PUNCT
bam-5830	239	26	is	be	AUX
bam-5830	239	27	able	able	ADJ
bam-5830	239	28	to	to	PART
bam-5830	239	29	act	act	VERB
bam-5830	239	30	as	as	ADP
bam-5830	239	31	trophic	trophic	ADJ
bam-5830	239	32	and	and	CCONJ
bam-5830	239	33	morphogenic	morphogenic	ADJ
bam-5830	239	34	factor	factor	NOUN
bam-5830	239	35	in	in	ADP
bam-5830	239	36	myoblasts	myoblast	NOUN
bam-5830	239	37	.	.	PUNCT
bam-5830	240	1	here	here	ADV
bam-5830	240	2	,	,	PUNCT
bam-5830	240	3	we	we	PRON
bam-5830	240	4	report	report	VERB
bam-5830	240	5	that	that	SCONJ
bam-5830	240	6	the	the	DET
bam-5830	240	7	inhibition	inhibition	NOUN
bam-5830	240	8	of	of	ADP
bam-5830	240	9	sphk1	sphk1	NOUN
bam-5830	240	10	by	by	ADP
bam-5830	240	11	specific	specific	ADJ
bam-5830	240	12	gene	gene	NOUN
bam-5830	240	13	silencing	silence	VERB
bam-5830	240	14	or	or	CCONJ
bam-5830	240	15	pharmacological	pharmacological	ADJ
bam-5830	240	16	inhibition	inhibition	NOUN
bam-5830	240	17	drastically	drastically	ADV
bam-5830	240	18	reduced	reduce	VERB
bam-5830	240	19	myotube	myotube	NOUN
bam-5830	240	20	size	size	NOUN
bam-5830	240	21	and	and	CCONJ
bam-5830	240	22	myonuclei	myonuclei	NOUN
bam-5830	240	23	number	number	NOUN
bam-5830	240	24	,	,	PUNCT
bam-5830	240	25	and	and	CCONJ
bam-5830	240	26	increased	increase	VERB
bam-5830	240	27	atrogin-1	atrogin-1	NUM
bam-5830	240	28	/	/	SYM
bam-5830	240	29	mafbx	mafbx	NOUN
bam-5830	240	30	expression	expression	NOUN
bam-5830	240	31	.	.	PUNCT
bam-5830	241	1	notably	notably	ADV
bam-5830	241	2	,	,	PUNCT
bam-5830	241	3	the	the	DET
bam-5830	241	4	atrophic	atrophic	ADJ
bam-5830	241	5	phenotype	phenotype	NOUN
bam-5830	241	6	of	of	ADP
bam-5830	241	7	c2c12	c2c12	PROPN
bam-5830	241	8	myotubes	myotube	NOUN
bam-5830	241	9	treated	treat	VERB
bam-5830	241	10	with	with	ADP
bam-5830	241	11	dexamethasone	dexamethasone	NOUN
bam-5830	241	12	and	and	CCONJ
bam-5830	241	13	of	of	ADP
bam-5830	241	14	muscle	muscle	NOUN
bam-5830	241	15	fibers	fiber	NOUN
bam-5830	241	16	obtained	obtain	VERB
bam-5830	241	17	from	from	ADP
bam-5830	241	18	cachectic	cachectic	ADJ
bam-5830	241	19	mice	mouse	NOUN
bam-5830	241	20	inoculated	inoculate	VERB
bam-5830	241	21	with	with	ADP
bam-5830	241	22	c26	c26	NOUN
bam-5830	241	23	adenocarcinoma	adenocarcinoma	NOUN
bam-5830	241	24	,	,	PUNCT
bam-5830	241	25	was	be	AUX
bam-5830	241	26	characterized	characterize	VERB
bam-5830	241	27	by	by	ADP
bam-5830	241	28	increased	increase	VERB
bam-5830	241	29	expression	expression	NOUN
bam-5830	241	30	of	of	ADP
bam-5830	241	31	atrogin-1	atrogin-1	PROPN
bam-5830	241	32	/	/	SYM
bam-5830	241	33	mafbx	mafbx	NOUN
bam-5830	241	34	and	and	CCONJ
bam-5830	241	35	reduced	reduced	ADJ
bam-5830	241	36	levels	level	NOUN
bam-5830	241	37	of	of	ADP
bam-5830	241	38	active	active	ADJ
bam-5830	241	39	sphk1	sphk1	NOUN
bam-5830	241	40	.	.	PUNCT
bam-5830	242	1	in	in	ADP
bam-5830	242	2	addition	addition	NOUN
bam-5830	242	3	,	,	PUNCT
bam-5830	242	4	we	we	PRON
bam-5830	242	5	found	find	VERB
bam-5830	242	6	that	that	SCONJ
bam-5830	242	7	c2c12	c2c12	PROPN
bam-5830	242	8	muscle	muscle	NOUN
bam-5830	242	9	cell	cell	NOUN
bam-5830	242	10	atrophy	atrophy	NOUN
bam-5830	242	11	was	be	AUX
bam-5830	242	12	accomplished	accomplish	VERB
bam-5830	242	13	by	by	ADP
bam-5830	242	14	changes	change	NOUN
bam-5830	242	15	in	in	ADP
bam-5830	242	16	the	the	DET
bam-5830	242	17	pattern	pattern	NOUN
bam-5830	242	18	of	of	ADP
bam-5830	242	19	expression	expression	NOUN
bam-5830	242	20	of	of	ADP
bam-5830	242	21	s1p	s1p	PROPN
bam-5830	242	22	receptor	receptor	NOUN
bam-5830	242	23	subtypes	subtype	NOUN
bam-5830	242	24	(	(	PUNCT
bam-5830	242	25	s1prs	s1prs	NUM
bam-5830	242	26	)	)	PUNCT
bam-5830	242	27	and	and	CCONJ
bam-5830	242	28	treatment	treatment	NOUN
bam-5830	242	29	of	of	ADP
bam-5830	242	30	myotubes	myotube	NOUN
bam-5830	242	31	with	with	ADP
bam-5830	242	32	s1p	s1p	PROPN
bam-5830	242	33	was	be	AUX
bam-5830	242	34	able	able	ADJ
bam-5830	242	35	to	to	PART
bam-5830	242	36	prevent	prevent	VERB
bam-5830	242	37	dexa	dexa	NOUN
bam-5830	242	38	-	-	PUNCT
bam-5830	242	39	induced	induce	VERB
bam-5830	242	40	atrophic	atrophic	ADJ
bam-5830	242	41	marker	marker	NOUN
bam-5830	242	42	expression	expression	NOUN
bam-5830	242	43	.	.	PUNCT
bam-5830	243	1	finally	finally	ADV
bam-5830	243	2	,	,	PUNCT
bam-5830	243	3	by	by	ADP
bam-5830	243	4	using	use	VERB
bam-5830	243	5	specific	specific	ADJ
bam-5830	243	6	s1pr	s1pr	PUNCT
bam-5830	243	7	agonists	agonist	NOUN
bam-5830	243	8	and	and	CCONJ
bam-5830	243	9	antagonists	antagonist	NOUN
bam-5830	243	10	,	,	PUNCT
bam-5830	243	11	we	we	PRON
bam-5830	243	12	extended	extend	VERB
bam-5830	243	13	the	the	DET
bam-5830	243	14	investigation	investigation	NOUN
bam-5830	243	15	on	on	ADP
bam-5830	243	16	the	the	DET
bam-5830	243	17	role	role	NOUN
bam-5830	243	18	played	play	VERB
bam-5830	243	19	by	by	ADP
bam-5830	243	20	s1prs	s1prs	PROPN
bam-5830	243	21	in	in	ADP
bam-5830	243	22	the	the	DET
bam-5830	243	23	control	control	NOUN
bam-5830	243	24	of	of	ADP
bam-5830	243	25	atrogin-1	atrogin-1	PROPN
bam-5830	243	26	/	/	SYM
bam-5830	243	27	mafbx	mafbx	NOUN
bam-5830	243	28	expression	expression	NOUN
bam-5830	243	29	.	.	PUNCT
bam-5830	244	1	altogether	altogether	ADV
bam-5830	244	2	,	,	PUNCT
bam-5830	244	3	these	these	DET
bam-5830	244	4	findings	finding	NOUN
bam-5830	244	5	provide	provide	VERB
bam-5830	244	6	the	the	DET
bam-5830	244	7	first	first	ADJ
bam-5830	244	8	evidence	evidence	NOUN
bam-5830	244	9	that	that	PRON
bam-5830	244	10	s1p	s1p	VERB
bam-5830	244	11	/	/	SYM
bam-5830	244	12	sphk1	sphk1	NOUN
bam-5830	244	13	/	/	SYM
bam-5830	244	14	s1pr	s1pr	NOUN
bam-5830	244	15	axis	axis	NOUN
bam-5830	244	16	acts	act	VERB
bam-5830	244	17	as	as	ADP
bam-5830	244	18	a	a	DET
bam-5830	244	19	molecular	molecular	ADJ
bam-5830	244	20	regulator	regulator	NOUN
bam-5830	244	21	of	of	ADP
bam-5830	244	22	skeletal	skeletal	ADJ
bam-5830	244	23	muscle	muscle	NOUN
bam-5830	244	24	atrophy	atrophy	NOUN
bam-5830	244	25	,	,	PUNCT
bam-5830	244	26	thereby	thereby	ADV
bam-5830	244	27	representing	represent	VERB
bam-5830	244	28	a	a	DET
bam-5830	244	29	new	new	ADJ
bam-5830	244	30	possible	possible	ADJ
bam-5830	244	31	target	target	NOUN
bam-5830	244	32	for	for	ADP
bam-5830	244	33	therapy	therapy	NOUN
bam-5830	244	34	in	in	ADP
bam-5830	244	35	many	many	ADJ
bam-5830	244	36	physiological	physiological	ADJ
bam-5830	244	37	and	and	CCONJ
bam-5830	244	38	pathological	pathological	ADJ
bam-5830	244	39	conditions	condition	NOUN
bam-5830	244	40	.	.	PUNCT
bam-5830	245	1	*	*	PUNCT
bam-5830	245	2	*	*	PUNCT
bam-5830	245	3	*	*	PUNCT
bam-5830	245	4	*	*	PUNCT
bam-5830	245	5	*	*	PUNCT
bam-5830	245	6	interstitial	interstitial	ADJ
bam-5830	245	7	cell	cell	NOUN
bam-5830	245	8	activation	activation	NOUN
bam-5830	245	9	during	during	ADP
bam-5830	245	10	acute	acute	ADJ
bam-5830	245	11	muscle	muscle	NOUN
bam-5830	245	12	denervation	denervation	NOUN
bam-5830	245	13	m.	m.	NOUN
bam-5830	245	14	passafaro	passafaro	NOUN
bam-5830	245	15	1	1	NUM
bam-5830	245	16	,	,	PUNCT
bam-5830	245	17	l.	l.	PROPN
bam-5830	245	18	madaro	madaro	PROPN
bam-5830	245	19	1	1	NUM
bam-5830	245	20	,	,	PUNCT
bam-5830	245	21	l.	l.	PROPN
bam-5830	245	22	schirone	schirone	NOUN
bam-5830	245	23	1	1	NUM
bam-5830	245	24	,	,	PUNCT
bam-5830	245	25	l.berghella	l.berghella	NOUN
bam-5830	245	26	1	1	NUM
bam-5830	245	27	,	,	PUNCT
bam-5830	245	28	p.l	p.l	PROPN
bam-5830	245	29	.	.	PROPN
bam-5830	245	30	puri	puri	PROPN
bam-5830	245	31	1,2	1,2	NUM
bam-5830	245	32	1	1	NUM
bam-5830	245	33	.	.	PUNCT
bam-5830	246	1	irccs	ircc	VERB
bam-5830	246	2	fondazione	fondazione	PROPN
bam-5830	246	3	santa	santa	PROPN
bam-5830	246	4	lucia	lucia	PROPN
bam-5830	246	5	.	.	PUNCT
bam-5830	247	1	rome	rome	PROPN
bam-5830	247	2	,	,	PUNCT
bam-5830	247	3	italy	italy	PROPN
bam-5830	247	4	;	;	PUNCT
bam-5830	247	5	2.sanfordburnham	2.sanfordburnham	NUM
bam-5830	247	6	institute	institute	NOUN
bam-5830	247	7	for	for	ADP
bam-5830	247	8	medical	medical	ADJ
bam-5830	247	9	research	research	NOUN
bam-5830	247	10	,	,	PUNCT
bam-5830	247	11	la	la	PROPN
bam-5830	247	12	jolla	jolla	PROPN
bam-5830	247	13	,	,	PUNCT
bam-5830	247	14	ca	ca	PROPN
bam-5830	247	15	.	.	PUNCT
bam-5830	248	1	usa	usa	PROPN
bam-5830	248	2	e	e	PROPN
bam-5830	248	3	-	-	NOUN
bam-5830	248	4	mail	mail	NOUN
bam-5830	248	5	:	:	PUNCT
bam-5830	248	6	magda.passafaro@gmail.com	magda.passafaro@gmail.com	X
bam-5830	248	7	skeletal	skeletal	ADJ
bam-5830	248	8	muscle	muscle	NOUN
bam-5830	248	9	is	be	AUX
bam-5830	248	10	a	a	DET
bam-5830	248	11	dynamic	dynamic	ADJ
bam-5830	248	12	tissue	tissue	NOUN
bam-5830	248	13	that	that	PRON
bam-5830	248	14	can	can	AUX
bam-5830	248	15	respond	respond	VERB
bam-5830	248	16	to	to	ADP
bam-5830	248	17	external	external	ADJ
bam-5830	248	18	stimuli	stimulus	NOUN
bam-5830	248	19	through	through	ADP
bam-5830	248	20	both	both	CCONJ
bam-5830	248	21	anabolic	anabolic	ADJ
bam-5830	248	22	and	and	CCONJ
bam-5830	248	23	catabolic	catabolic	ADJ
bam-5830	248	24	processes	process	NOUN
bam-5830	248	25	.	.	PUNCT
bam-5830	249	1	in	in	ADP
bam-5830	249	2	a	a	DET
bam-5830	249	3	variety	variety	NOUN
bam-5830	249	4	of	of	ADP
bam-5830	249	5	conditions	condition	NOUN
bam-5830	249	6	,	,	PUNCT
bam-5830	249	7	including	include	VERB
bam-5830	249	8	immobilization	immobilization	NOUN
bam-5830	249	9	,	,	PUNCT
bam-5830	249	10	aids	aid	NOUN
bam-5830	249	11	and	and	CCONJ
bam-5830	249	12	neuromuscular	neuromuscular	ADJ
bam-5830	249	13	disorders	disorder	NOUN
bam-5830	249	14	,	,	PUNCT
bam-5830	249	15	skeletal	skeletal	ADJ
bam-5830	249	16	muscle	muscle	NOUN
bam-5830	249	17	mass	mass	NOUN
bam-5830	249	18	is	be	AUX
bam-5830	249	19	decreased	decrease	VERB
bam-5830	249	20	(	(	PUNCT
bam-5830	249	21	atrophy	atrophy	NOUN
bam-5830	249	22	)	)	PUNCT
bam-5830	249	23	.	.	PUNCT
bam-5830	250	1	upon	upon	SCONJ
bam-5830	250	2	denervation	denervation	NOUN
bam-5830	250	3	or	or	CCONJ
bam-5830	250	4	disuse	disuse	NOUN
bam-5830	250	5	,	,	PUNCT
bam-5830	250	6	skeletal	skeletal	ADJ
bam-5830	250	7	muscle	muscle	NOUN
bam-5830	250	8	undergoes	undergo	VERB
bam-5830	250	9	atrophy	atrophy	NOUN
bam-5830	250	10	,	,	PUNCT
bam-5830	250	11	leading	lead	VERB
bam-5830	250	12	to	to	ADP
bam-5830	250	13	reduced	reduced	ADJ
bam-5830	250	14	size	size	NOUN
bam-5830	250	15	of	of	ADP
bam-5830	250	16	myofibers	myofiber	NOUN
bam-5830	250	17	,	,	PUNCT
bam-5830	250	18	impaired	impaired	ADJ
bam-5830	250	19	contractile	contractile	NOUN
bam-5830	250	20	and	and	CCONJ
bam-5830	250	21	metabolic	metabolic	NOUN
bam-5830	250	22	activities	activity	NOUN
bam-5830	250	23	.	.	PUNCT
bam-5830	251	1	previous	previous	ADJ
bam-5830	251	2	studies	study	NOUN
bam-5830	251	3	have	have	AUX
bam-5830	251	4	identified	identify	VERB
bam-5830	251	5	key	key	ADJ
bam-5830	251	6	molecular	molecular	ADJ
bam-5830	251	7	pathways	pathway	NOUN
bam-5830	251	8	leading	lead	VERB
bam-5830	251	9	to	to	ADP
bam-5830	251	10	protein	protein	NOUN
bam-5830	251	11	breakdown	breakdown	NOUN
bam-5830	251	12	and	and	CCONJ
bam-5830	251	13	degradation	degradation	NOUN
bam-5830	251	14	of	of	ADP
bam-5830	251	15	sarcomeric	sarcomeric	ADJ
bam-5830	251	16	proteins	protein	NOUN
bam-5830	251	17	;	;	PUNCT
bam-5830	251	18	yet	yet	CCONJ
bam-5830	251	19	,	,	PUNCT
bam-5830	251	20	it	it	PRON
bam-5830	251	21	remains	remain	VERB
bam-5830	251	22	a	a	DET
bam-5830	251	23	gap	gap	NOUN
bam-5830	251	24	of	of	ADP
bam-5830	251	25	knowledge	knowledge	NOUN
bam-5830	251	26	on	on	ADP
bam-5830	251	27	whether	whether	SCONJ
bam-5830	251	28	muscle	muscle	NOUN
bam-5830	251	29	resident	resident	ADJ
bam-5830	251	30	cell	cell	NOUN
bam-5830	251	31	populations	population	NOUN
bam-5830	251	32	can	can	AUX
bam-5830	251	33	regulate	regulate	VERB
bam-5830	251	34	the	the	DET
bam-5830	251	35	response	response	NOUN
bam-5830	251	36	of	of	ADP
bam-5830	251	37	muscle	muscle	NOUN
bam-5830	251	38	to	to	ADP
bam-5830	251	39	atrophic	atrophic	ADJ
bam-5830	251	40	stimuli	stimulus	NOUN
bam-5830	251	41	.	.	PUNCT
bam-5830	252	1	indeed	indeed	ADV
bam-5830	252	2	,	,	PUNCT
bam-5830	252	3	the	the	DET
bam-5830	252	4	recent	recent	ADJ
bam-5830	252	5	identification	identification	NOUN
bam-5830	252	6	of	of	ADP
bam-5830	252	7	muscle	muscle	NOUN
bam-5830	252	8	-	-	PUNCT
bam-5830	252	9	derived	derive	VERB
bam-5830	252	10	interstitial	interstitial	ADJ
bam-5830	252	11	cells	cell	NOUN
bam-5830	252	12	,	,	PUNCT
bam-5830	252	13	named	name	VERB
bam-5830	252	14	fibro	fibro	NOUN
bam-5830	252	15	-	-	PUNCT
bam-5830	252	16	adipogenic	adipogenic	ADJ
bam-5830	252	17	progenitors	progenitor	NOUN
bam-5830	252	18	,	,	PUNCT
bam-5830	252	19	that	that	PRON
bam-5830	252	20	can	can	AUX
bam-5830	252	21	adopt	adopt	VERB
bam-5830	252	22	multiple	multiple	ADJ
bam-5830	252	23	lineages	lineage	NOUN
bam-5830	252	24	and	and	CCONJ
bam-5830	252	25	contribute	contribute	VERB
bam-5830	252	26	,	,	PUNCT
bam-5830	252	27	either	either	CCONJ
bam-5830	252	28	directly	directly	ADV
bam-5830	252	29	o	o	X
bam-5830	252	30	indirectly	indirectly	ADV
bam-5830	252	31	,	,	PUNCT
bam-5830	252	32	to	to	PART
bam-5830	252	33	muscle	muscle	NOUN
bam-5830	252	34	regeneration	regeneration	NOUN
bam-5830	252	35	(	(	PUNCT
bam-5830	252	36	joe	joe	PROPN
bam-5830	252	37	et	et	PROPN
bam-5830	252	38	al,2010	al,2010	PROPN
bam-5830	252	39	;	;	PUNCT
bam-5830	252	40	uezumi	uezumi	PROPN
bam-5830	252	41	et	et	PROPN
bam-5830	252	42	al,2010	al,2010	PROPN
bam-5830	252	43	)	)	PUNCT
bam-5830	252	44	indicates	indicate	VERB
bam-5830	252	45	a	a	DET
bam-5830	252	46	previously	previously	ADV
bam-5830	252	47	unrecognized	unrecognize	VERB
bam-5830	252	48	complexity	complexity	NOUN
bam-5830	252	49	in	in	ADP
bam-5830	252	50	the	the	DET
bam-5830	252	51	regulation	regulation	NOUN
bam-5830	252	52	of	of	ADP
bam-5830	252	53	muscle	muscle	NOUN
bam-5830	252	54	homeostasis	homeostasis	NOUN
bam-5830	252	55	(	(	PUNCT
bam-5830	252	56	saccone	saccone	NOUN
bam-5830	252	57	et	et	PROPN
bam-5830	252	58	al,2014	al,2014	PROPN
bam-5830	252	59	)	)	PUNCT
bam-5830	252	60	.	.	PUNCT
bam-5830	253	1	we	we	PRON
bam-5830	253	2	have	have	AUX
bam-5830	253	3	discovered	discover	VERB
bam-5830	253	4	an	an	DET
bam-5830	253	5	unexpected	unexpected	ADJ
bam-5830	253	6	key	key	ADJ
bam-5830	253	7	role	role	NOUN
bam-5830	253	8	of	of	ADP
bam-5830	253	9	specific	specific	ADJ
bam-5830	253	10	muscle	muscle	NOUN
bam-5830	253	11	-	-	PUNCT
bam-5830	253	12	derived	derive	VERB
bam-5830	253	13	mononuclear	mononuclear	ADJ
bam-5830	253	14	cells	cell	NOUN
bam-5830	253	15	in	in	ADP
bam-5830	253	16	the	the	DET
bam-5830	253	17	pathogenesis	pathogenesis	NOUN
bam-5830	253	18	of	of	ADP
bam-5830	253	19	muscle	muscle	NOUN
bam-5830	253	20	atrophy	atrophy	NOUN
bam-5830	253	21	.	.	PUNCT
bam-5830	254	1	the	the	DET
bam-5830	254	2	characterization	characterization	NOUN
bam-5830	254	3	of	of	ADP
bam-5830	254	4	the	the	DET
bam-5830	254	5	mechanism	mechanism	NOUN
bam-5830	254	6	by	by	ADP
bam-5830	254	7	which	which	PRON
bam-5830	254	8	these	these	DET
bam-5830	254	9	cells	cell	NOUN
bam-5830	254	10	contribute	contribute	VERB
bam-5830	254	11	to	to	ADP
bam-5830	254	12	the	the	DET
bam-5830	254	13	loss	loss	NOUN
bam-5830	254	14	of	of	ADP
bam-5830	254	15	muscle	muscle	NOUN
bam-5830	254	16	mass	mass	NOUN
bam-5830	254	17	may	may	AUX
bam-5830	254	18	lead	lead	VERB
bam-5830	254	19	to	to	ADP
bam-5830	254	20	the	the	DET
bam-5830	254	21	identification	identification	NOUN
bam-5830	254	22	of	of	ADP
bam-5830	254	23	new	new	ADJ
bam-5830	254	24	therapeutic	therapeutic	ADJ
bam-5830	254	25	targets	target	NOUN
bam-5830	254	26	to	to	PART
bam-5830	254	27	counteract	counteract	VERB
bam-5830	254	28	muscolar	muscolar	ADJ
bam-5830	254	29	atrophy	atrophy	NOUN
bam-5830	254	30	.	.	PUNCT
bam-5830	255	1	*	*	PUNCT
bam-5830	255	2	*	*	PUNCT
bam-5830	255	3	*	*	PUNCT
bam-5830	255	4	*	*	PUNCT
bam-5830	255	5	*	*	PUNCT
bam-5830	255	6	pgc-1α	pgc-1α	NOUN
bam-5830	255	7	overexpression	overexpression	NOUN
bam-5830	255	8	promotes	promote	VERB
bam-5830	255	9	myogenesis	myogenesis	NOUN
bam-5830	255	10	:	:	PUNCT
bam-5830	255	11	relevance	relevance	NOUN
bam-5830	255	12	to	to	ADP
bam-5830	255	13	cancer	cancer	NOUN
bam-5830	255	14	-	-	PUNCT
bam-5830	255	15	induced	induce	VERB
bam-5830	255	16	muscle	muscle	NOUN
bam-5830	255	17	wasting	waste	VERB
bam-5830	255	18	?	?	PUNCT
bam-5830	256	1	f.	f.	PROPN
bam-5830	256	2	pin	pin	PROPN
bam-5830	256	3	1	1	NUM
bam-5830	256	4	,	,	PUNCT
bam-5830	256	5	r.	r.	PROPN
bam-5830	256	6	ballarò	ballarò	PROPN
bam-5830	256	7	1	1	NUM
bam-5830	256	8	,	,	PUNCT
bam-5830	256	9	d.	d.	PROPN
bam-5830	256	10	costamagna	costamagna	PROPN
bam-5830	256	11	2	2	NUM
bam-5830	256	12	,	,	PUNCT
bam-5830	256	13	f.	f.	PROPN
bam-5830	256	14	penna	penna	PROPN
bam-5830	256	15	1	1	NUM
bam-5830	256	16	,	,	PUNCT
bam-5830	256	17	p.	p.	NOUN
bam-5830	256	18	costelli	costelli	NOUN
bam-5830	256	19	1	1	NUM
bam-5830	256	20	1	1	X
bam-5830	256	21	.	.	PUNCT
bam-5830	257	1	department	department	NOUN
bam-5830	257	2	of	of	ADP
bam-5830	257	3	clinical	clinical	ADJ
bam-5830	257	4	and	and	CCONJ
bam-5830	257	5	biological	biological	ADJ
bam-5830	257	6	sciences	science	NOUN
bam-5830	257	7	,	,	PUNCT
bam-5830	257	8	experimental	experimental	ADJ
bam-5830	257	9	medicine	medicine	NOUN
bam-5830	257	10	and	and	CCONJ
bam-5830	257	11	clinical	clinical	ADJ
bam-5830	257	12	pathology	pathology	NOUN
bam-5830	257	13	unit	unit	NOUN
bam-5830	257	14	,	,	PUNCT
bam-5830	257	15	university	university	PROPN
bam-5830	257	16	of	of	ADP
bam-5830	257	17	turin	turin	PROPN
bam-5830	257	18	,	,	PUNCT
bam-5830	257	19	italy	italy	PROPN
bam-5830	257	20	;	;	PUNCT
bam-5830	257	21	2	2	X
bam-5830	257	22	.	.	PUNCT
bam-5830	257	23	translational	translational	ADJ
bam-5830	257	24	cardiomyology	cardiomyology	NOUN
bam-5830	257	25	,	,	PUNCT
bam-5830	257	26	stem	stem	NOUN
bam-5830	257	27	cell	cell	NOUN
bam-5830	257	28	biology	biology	NOUN
bam-5830	257	29	and	and	CCONJ
bam-5830	257	30	embryology	embryology	NOUN
bam-5830	257	31	,	,	PUNCT
bam-5830	257	32	department	department	NOUN
bam-5830	257	33	of	of	ADP
bam-5830	257	34	development	development	NOUN
bam-5830	257	35	and	and	CCONJ
bam-5830	257	36	regeneration	regeneration	NOUN
bam-5830	257	37	,	,	PUNCT
bam-5830	257	38	university	university	NOUN
bam-5830	257	39	hospital	hospital	NOUN
bam-5830	257	40	gasthuisberg	gasthuisberg	PROPN
bam-5830	257	41	,	,	PUNCT
bam-5830	257	42	leuven	leuven	PROPN
bam-5830	257	43	,	,	PUNCT
bam-5830	257	44	belgium	belgium	NOUN
bam-5830	257	45	.	.	PUNCT
bam-5830	258	1	e	e	X
bam-5830	258	2	-	-	NOUN
bam-5830	258	3	mail	mail	NOUN
bam-5830	258	4	:	:	PUNCT
bam-5830	258	5	riccardo.ballaro@unito.it	riccardo.ballaro@unito.it	PROPN
bam-5830	258	6	pgc-1α	pgc-1α	NOUN
bam-5830	258	7	overexpression	overexpression	NOUN
bam-5830	258	8	is	be	AUX
bam-5830	258	9	able	able	ADJ
bam-5830	258	10	to	to	PART
bam-5830	258	11	protect	protect	VERB
bam-5830	258	12	skeletal	skeletal	ADJ
bam-5830	258	13	muscle	muscle	NOUN
bam-5830	258	14	from	from	ADP
bam-5830	258	15	fasting	fast	VERB
bam-5830	258	16	or	or	CCONJ
bam-5830	258	17	denervation	denervation	NOUN
bam-5830	258	18	-	-	PUNCT
bam-5830	258	19	induced	induce	VERB
bam-5830	258	20	atrophy	atrophy	NOUN
bam-5830	258	21	(	(	PUNCT
bam-5830	258	22	1	1	NUM
bam-5830	258	23	)	)	PUNCT
bam-5830	258	24	and	and	CCONJ
bam-5830	258	25	to	to	PART
bam-5830	258	26	improve	improve	VERB
bam-5830	258	27	sarcopenia	sarcopenia	NOUN
bam-5830	258	28	in	in	ADP
bam-5830	258	29	old	old	ADJ
bam-5830	258	30	mice	mouse	NOUN
bam-5830	258	31	(	(	PUNCT
bam-5830	258	32	2	2	NUM
bam-5830	258	33	)	)	PUNCT
bam-5830	258	34	.	.	PUNCT
bam-5830	259	1	consistently	consistently	ADV
bam-5830	259	2	,	,	PUNCT
bam-5830	259	3	in	in	ADP
bam-5830	259	4	the	the	DET
bam-5830	259	5	skeletal	skeletal	ADJ
bam-5830	259	6	muscle	muscle	NOUN
bam-5830	259	7	of	of	ADP
bam-5830	259	8	cachectic	cachectic	ADJ
bam-5830	259	9	tumor	tumor	NOUN
bam-5830	259	10	-	-	PUNCT
bam-5830	259	11	bearing	bear	VERB
bam-5830	259	12	mice	mouse	NOUN
bam-5830	259	13	,	,	PUNCT
bam-5830	259	14	pgc-1α	pgc-1α	NOUN
bam-5830	259	15	expression	expression	NOUN
bam-5830	259	16	is	be	AUX
bam-5830	259	17	reduced	reduce	VERB
bam-5830	259	18	(	(	PUNCT
bam-5830	259	19	3	3	NUM
bam-5830	259	20	)	)	PUNCT
bam-5830	259	21	,	,	PUNCT
bam-5830	259	22	in	in	ADP
bam-5830	259	23	association	association	NOUN
bam-5830	259	24	with	with	ADP
bam-5830	259	25	the	the	DET
bam-5830	259	26	accumulation	accumulation	NOUN
bam-5830	259	27	of	of	ADP
bam-5830	259	28	pax7	pax7	PROPN
bam-5830	259	29	+	+	CCONJ
bam-5830	259	30	cells	cell	NOUN
bam-5830	259	31	,	,	PUNCT
bam-5830	259	32	which	which	PRON
bam-5830	259	33	is	be	AUX
bam-5830	259	34	suggestive	suggestive	ADJ
bam-5830	259	35	of	of	ADP
bam-5830	259	36	an	an	DET
bam-5830	259	37	impairment	impairment	NOUN
bam-5830	259	38	of	of	ADP
bam-5830	259	39	myogenesis	myogenesis	NOUN
bam-5830	259	40	(	(	PUNCT
bam-5830	259	41	4	4	NUM
bam-5830	259	42	)	)	PUNCT
bam-5830	259	43	.	.	PUNCT
bam-5830	260	1	preliminary	preliminary	ADJ
bam-5830	260	2	observations	observation	NOUN
bam-5830	260	3	obtained	obtain	VERB
bam-5830	260	4	in	in	ADP
bam-5830	260	5	mice	mouse	NOUN
bam-5830	260	6	overexpressing	overexpresse	VERB
bam-5830	260	7	pgc-1α	pgc-1α	NOUN
bam-5830	260	8	specifically	specifically	ADV
bam-5830	260	9	in	in	ADP
bam-5830	260	10	the	the	DET
bam-5830	260	11	skeletal	skeletal	ADJ
bam-5830	260	12	muscle	muscle	NOUN
bam-5830	260	13	show	show	VERB
bam-5830	260	14	that	that	SCONJ
bam-5830	260	15	the	the	DET
bam-5830	260	16	number	number	NOUN
bam-5830	260	17	of	of	ADP
bam-5830	260	18	cd34+/sca1	cd34+/sca1	NOUN
bam-5830	260	19	+	+	CCONJ
bam-5830	260	20	cells	cell	NOUN
bam-5830	260	21	,	,	PUNCT
bam-5830	260	22	both	both	DET
bam-5830	260	23	integrin	integrin	NOUN
bam-5830	260	24	-	-	PUNCT
bam-5830	260	25	α7	α7	NOUN
bam-5830	260	26	positive	positive	ADJ
bam-5830	260	27	(	(	PUNCT
bam-5830	260	28	satellite	satellite	NOUN
bam-5830	260	29	cells	cell	NOUN
bam-5830	260	30	)	)	PUNCT
bam-5830	260	31	and	and	CCONJ
bam-5830	260	32	negative	negative	ADJ
bam-5830	260	33	(	(	PUNCT
bam-5830	260	34	other	other	ADJ
bam-5830	260	35	myogenic	myogenic	ADJ
bam-5830	260	36	precursors	precursor	NOUN
bam-5830	260	37	)	)	PUNCT
bam-5830	260	38	,	,	PUNCT
bam-5830	260	39	was	be	AUX
bam-5830	260	40	higher	high	ADJ
bam-5830	260	41	in	in	ADP
bam-5830	260	42	the	the	DET
bam-5830	260	43	muscle	muscle	NOUN
bam-5830	260	44	of	of	ADP
bam-5830	260	45	transgenic	transgenic	NOUN
bam-5830	260	46	(	(	PUNCT
bam-5830	260	47	tg	tg	NOUN
bam-5830	260	48	)	)	PUNCT
bam-5830	260	49	mice	mouse	NOUN
bam-5830	260	50	than	than	ADP
bam-5830	260	51	in	in	ADP
bam-5830	260	52	those	those	PRON
bam-5830	260	53	of	of	ADP
bam-5830	260	54	wild	wild	ADJ
bam-5830	260	55	-	-	PUNCT
bam-5830	260	56	type	type	NOUN
bam-5830	260	57	(	(	PUNCT
bam-5830	260	58	wt	wt	NOUN
bam-5830	260	59	)	)	PUNCT
bam-5830	260	60	animals	animal	NOUN
bam-5830	260	61	.	.	PUNCT
bam-5830	261	1	not	not	PART
bam-5830	261	2	only	only	ADV
bam-5830	261	3	,	,	PUNCT
bam-5830	261	4	myotubes	myotube	NOUN
bam-5830	261	5	originating	originate	VERB
bam-5830	261	6	from	from	ADP
bam-5830	261	7	tg	tg	ADV
bam-5830	261	8	-	-	PUNCT
bam-5830	261	9	derived	derive	VERB
bam-5830	261	10	myogenic	myogenic	ADJ
bam-5830	261	11	precursors	precursor	NOUN
bam-5830	261	12	were	be	AUX
bam-5830	261	13	increased	increase	VERB
bam-5830	261	14	in	in	ADP
bam-5830	261	15	both	both	PRON
bam-5830	261	16	number	number	NOUN
bam-5830	261	17	and	and	CCONJ
bam-5830	261	18	size	size	NOUN
bam-5830	261	19	in	in	ADP
bam-5830	261	20	comparison	comparison	NOUN
bam-5830	261	21	to	to	ADP
bam-5830	261	22	those	those	PRON
bam-5830	261	23	obtained	obtain	VERB
bam-5830	261	24	from	from	ADP
bam-5830	261	25	wt	wt	NOUN
bam-5830	261	26	progenitors	progenitor	NOUN
bam-5830	261	27	.	.	PUNCT
bam-5830	262	1	aim	aim	NOUN
bam-5830	262	2	of	of	ADP
bam-5830	262	3	the	the	DET
bam-5830	262	4	present	present	ADJ
bam-5830	262	5	study	study	NOUN
bam-5830	262	6	was	be	AUX
bam-5830	262	7	to	to	PART
bam-5830	262	8	investigate	investigate	VERB
bam-5830	262	9	if	if	SCONJ
bam-5830	262	10	pgc-1α	pgc-1α	NOUN
bam-5830	262	11	overexpression	overexpression	NOUN
bam-5830	262	12	can	can	AUX
bam-5830	262	13	improve	improve	VERB
bam-5830	262	14	the	the	DET
bam-5830	262	15	regenerative	regenerative	ADJ
bam-5830	262	16	capacity	capacity	NOUN
bam-5830	262	17	in	in	ADP
bam-5830	262	18	the	the	DET
bam-5830	262	19	muscle	muscle	NOUN
bam-5830	262	20	of	of	ADP
bam-5830	262	21	tumor	tumor	NOUN
bam-5830	262	22	(	(	PUNCT
bam-5830	262	23	c26)-bearing	c26)-beare	VERB
bam-5830	262	24	animals	animal	NOUN
bam-5830	262	25	after	after	ADP
bam-5830	262	26	chemically	chemically	ADV
bam-5830	262	27	-	-	PUNCT
bam-5830	262	28	induced	induce	VERB
bam-5830	262	29	injury	injury	NOUN
bam-5830	262	30	.	.	PUNCT
bam-5830	263	1	bacl2	bacl2	NOUN
bam-5830	263	2	(	(	PUNCT
bam-5830	263	3	30	30	NUM
bam-5830	263	4	μl	μl	ADJ
bam-5830	263	5	,	,	PUNCT
bam-5830	263	6	1.2	1.2	NUM
bam-5830	263	7	%	%	NOUN
bam-5830	263	8	w	w	PROPN
bam-5830	263	9	/	/	SYM
bam-5830	263	10	v	v	NOUN
bam-5830	263	11	)	)	PUNCT
bam-5830	263	12	was	be	AUX
bam-5830	263	13	injected	inject	VERB
bam-5830	263	14	in	in	ADP
bam-5830	263	15	the	the	DET
bam-5830	263	16	tibialis	tibialis	PROPN
bam-5830	263	17	anterior	anterior	ADJ
bam-5830	263	18	muscle	muscle	NOUN
bam-5830	263	19	the	the	DET
bam-5830	263	20	day	day	NOUN
bam-5830	263	21	after	after	ADP
bam-5830	263	22	tumor	tumor	NOUN
bam-5830	263	23	implantation	implantation	NOUN
bam-5830	263	24	.	.	PUNCT
bam-5830	264	1	thirteen	thirteen	NUM
bam-5830	264	2	days	day	NOUN
bam-5830	264	3	after	after	ADP
bam-5830	264	4	injury	injury	NOUN
bam-5830	264	5	,	,	PUNCT
bam-5830	264	6	both	both	PRON
bam-5830	264	7	wt	wt	NOUN
bam-5830	264	8	and	and	CCONJ
bam-5830	264	9	tg	tg	PROPN
bam-5830	264	10	controls	control	VERB
bam-5830	264	11	almost	almost	ADV
bam-5830	264	12	completely	completely	ADV
bam-5830	264	13	recovered	recover	VERB
bam-5830	264	14	the	the	DET
bam-5830	264	15	initial	initial	ADJ
bam-5830	264	16	myofiber	myofiber	PROPN
bam-5830	264	17	cross	cross	PROPN
bam-5830	264	18	sectional	sectional	ADJ
bam-5830	264	19	area	area	NOUN
bam-5830	264	20	(	(	PUNCT
bam-5830	264	21	csa	csa	PROPN
bam-5830	264	22	;	;	PUNCT
bam-5830	264	23	70	70	NUM
bam-5830	264	24	%	%	NOUN
bam-5830	264	25	of	of	ADP
bam-5830	264	26	uninjured	uninjured	ADJ
bam-5830	264	27	muscle	muscle	NOUN
bam-5830	264	28	)	)	PUNCT
bam-5830	264	29	.	.	PUNCT
bam-5830	265	1	by	by	ADP
bam-5830	265	2	contrast	contrast	NOUN
bam-5830	265	3	,	,	PUNCT
bam-5830	265	4	csa	csa	PROPN
bam-5830	265	5	recovery	recovery	NOUN
bam-5830	265	6	was	be	AUX
bam-5830	265	7	markedly	markedly	ADV
bam-5830	265	8	delayed	delay	VERB
bam-5830	265	9	in	in	ADP
bam-5830	265	10	wt	wt	ADP
bam-5830	265	11	or	or	CCONJ
bam-5830	265	12	tg	tg	ADV
bam-5830	265	13	tumor	tumor	NOUN
bam-5830	265	14	-	-	PUNCT
bam-5830	265	15	bearing	bear	VERB
bam-5830	265	16	mice	mouse	NOUN
bam-5830	265	17	(	(	PUNCT
bam-5830	265	18	30	30	NUM
bam-5830	265	19	%	%	NOUN
bam-5830	265	20	of	of	ADP
bam-5830	265	21	uninjured	uninjured	ADJ
bam-5830	265	22	muscle	muscle	NOUN
bam-5830	265	23	)	)	PUNCT
bam-5830	265	24	.	.	PUNCT
bam-5830	266	1	such	such	DET
bam-5830	266	2	a	a	DET
bam-5830	266	3	lack	lack	NOUN
bam-5830	266	4	of	of	ADP
bam-5830	266	5	csa	csa	PROPN
bam-5830	266	6	rescue	rescue	PROPN
bam-5830	266	7	in	in	ADP
bam-5830	266	8	tg	tg	PROPN
bam-5830	266	9	c26	c26	NOUN
bam-5830	266	10	hosts	host	NOUN
bam-5830	266	11	occurred	occur	VERB
bam-5830	266	12	despite	despite	SCONJ
bam-5830	266	13	tg	tg	PROPN
bam-5830	266	14	mice	mouse	NOUN
bam-5830	266	15	constitutively	constitutively	ADV
bam-5830	266	16	possess	possess	VERB
bam-5830	266	17	a	a	DET
bam-5830	266	18	number	number	NOUN
bam-5830	266	19	of	of	ADP
bam-5830	266	20	myogenic	myogenic	ADJ
bam-5830	266	21	precursors	precursor	NOUN
bam-5830	266	22	higher	high	ADJ
bam-5830	266	23	than	than	ADP
bam-5830	266	24	wt	wt	NOUN
bam-5830	266	25	animals	animal	NOUN
bam-5830	266	26	.	.	PUNCT
bam-5830	267	1	as	as	ADP
bam-5830	267	2	an	an	DET
bam-5830	267	3	estimate	estimate	NOUN
bam-5830	267	4	of	of	ADP
bam-5830	267	5	mitochondria	mitochondria	PROPN
bam-5830	267	6	number	number	NOUN
bam-5830	267	7	,	,	PUNCT
bam-5830	267	8	cytochrome	cytochrome	NOUN
bam-5830	267	9	c	c	NOUN
bam-5830	267	10	expression	expression	NOUN
bam-5830	267	11	was	be	AUX
bam-5830	267	12	evaluated	evaluate	VERB
bam-5830	267	13	.	.	PUNCT
bam-5830	268	1	the	the	DET
bam-5830	268	2	results	result	NOUN
bam-5830	268	3	show	show	VERB
bam-5830	268	4	that	that	SCONJ
bam-5830	268	5	cytochrome	cytochrome	NOUN
bam-5830	268	6	c	c	NOUN
bam-5830	268	7	levels	level	NOUN
bam-5830	268	8	were	be	AUX
bam-5830	268	9	significantly	significantly	ADV
bam-5830	268	10	reduced	reduce	VERB
bam-5830	268	11	in	in	ADP
bam-5830	268	12	the	the	DET
bam-5830	268	13	regenerating	regenerate	VERB
bam-5830	268	14	muscle	muscle	NOUN
bam-5830	268	15	of	of	ADP
bam-5830	268	16	wt	wt	PROPN
bam-5830	268	17	c26	c26	NOUN
bam-5830	268	18	hosts	host	NOUN
bam-5830	268	19	,	,	PUNCT
bam-5830	268	20	while	while	SCONJ
bam-5830	268	21	remained	remain	VERB
bam-5830	268	22	comparable	comparable	ADJ
bam-5830	268	23	to	to	ADP
bam-5830	268	24	those	those	PRON
bam-5830	268	25	of	of	ADP
bam-5830	268	26	uninjured	uninjured	ADJ
bam-5830	268	27	muscle	muscle	NOUN
bam-5830	268	28	in	in	ADP
bam-5830	268	29	bacl2	bacl2	NOUN
bam-5830	268	30	-	-	PUNCT
bam-5830	268	31	treated	treat	VERB
bam-5830	268	32	abstracts	abstract	NOUN
bam-5830	268	33	of	of	ADP
bam-5830	268	34	the	the	DET
bam-5830	268	35	xii	xii	PROPN
bam-5830	268	36	iim	iim	NOUN
bam-5830	268	37	myology	myology	NOUN
bam-5830	268	38	meeting	meeting	NOUN
bam-5830	268	39	october	october	PROPN
bam-5830	268	40	1–4	1–4	PROPN
bam-5830	268	41	,	,	PUNCT
bam-5830	268	42	2015	2015	NUM
bam-5830	268	43	eur	eur	PROPN
bam-5830	268	44	j	j	PROPN
bam-5830	268	45	transl	transl	PROPN
bam-5830	268	46	myol	myol	PROPN
bam-5830	268	47	basic	basic	ADJ
bam-5830	268	48	appl	appl	NOUN
bam-5830	268	49	myol	myol	NOUN
bam-5830	268	50	2016	2016	NUM
bam-5830	268	51	;	;	PUNCT
bam-5830	268	52	26	26	NUM
bam-5830	268	53	(	(	PUNCT
bam-5830	268	54	1):2	1):2	NUM
bam-5830	268	55	-	-	SYM
bam-5830	268	56	24	24	NUM
bam-5830	268	57	this	this	DET
bam-5830	268	58	article	article	NOUN
bam-5830	268	59	is	be	AUX
bam-5830	268	60	distributed	distribute	VERB
bam-5830	268	61	under	under	ADP
bam-5830	268	62	the	the	DET
bam-5830	268	63	terms	term	NOUN
bam-5830	268	64	of	of	ADP
bam-5830	268	65	the	the	DET
bam-5830	268	66	creative	creative	ADJ
bam-5830	268	67	commons	common	NOUN
bam-5830	268	68	attribution	attribution	NOUN
bam-5830	268	69	noncommercial	noncommercial	ADJ
bam-5830	268	70	license	license	NOUN
bam-5830	268	71	(	(	PUNCT
bam-5830	268	72	cc	cc	NOUN
bam-5830	268	73	by	by	ADP
bam-5830	268	74	-	-	PUNCT
bam-5830	268	75	nc	nc	PROPN
bam-5830	268	76	4.0	4.0	NUM
bam-5830	268	77	)	)	PUNCT
bam-5830	268	78	which	which	PRON
bam-5830	268	79	permits	permit	VERB
bam-5830	268	80	any	any	DET
bam-5830	268	81	noncommercial	noncommercial	ADJ
bam-5830	268	82	use	use	NOUN
bam-5830	268	83	,	,	PUNCT
bam-5830	268	84	distribution	distribution	NOUN
bam-5830	268	85	,	,	PUNCT
bam-5830	268	86	and	and	CCONJ
bam-5830	268	87	reproduction	reproduction	NOUN
bam-5830	268	88	in	in	ADP
bam-5830	268	89	any	any	DET
bam-5830	268	90	medium	medium	NOUN
bam-5830	268	91	,	,	PUNCT
bam-5830	268	92	provided	provide	VERB
bam-5830	268	93	the	the	DET
bam-5830	268	94	original	original	ADJ
bam-5830	268	95	author(s	author(s	NOUN
bam-5830	268	96	)	)	PUNCT
bam-5830	268	97	and	and	CCONJ
bam-5830	268	98	source	source	NOUN
bam-5830	268	99	are	be	AUX
bam-5830	268	100	credited	credit	VERB
bam-5830	268	101	.	.	PUNCT
bam-5830	269	1	10	10	NUM
bam-5830	269	2	tg	tg	PROPN
bam-5830	269	3	tumor	tumor	NOUN
bam-5830	269	4	bearers	bearer	NOUN
bam-5830	269	5	.	.	PUNCT
bam-5830	270	1	previous	previous	ADJ
bam-5830	270	2	observations	observation	NOUN
bam-5830	270	3	showed	show	VERB
bam-5830	270	4	that	that	SCONJ
bam-5830	270	5	inhibition	inhibition	NOUN
bam-5830	270	6	of	of	ADP
bam-5830	270	7	erk	erk	NOUN
bam-5830	270	8	activity	activity	NOUN
bam-5830	270	9	improved	improve	VERB
bam-5830	270	10	muscle	muscle	NOUN
bam-5830	270	11	wasting	waste	VERB
bam-5830	270	12	and	and	CCONJ
bam-5830	270	13	myogenesis	myogenesis	NOUN
bam-5830	270	14	in	in	ADP
bam-5830	270	15	the	the	DET
bam-5830	270	16	c26	c26	NOUN
bam-5830	270	17	hosts	host	NOUN
bam-5830	270	18	(	(	PUNCT
bam-5830	270	19	4	4	NUM
bam-5830	270	20	)	)	PUNCT
bam-5830	270	21	.	.	PUNCT
bam-5830	271	1	in	in	ADP
bam-5830	271	2	this	this	DET
bam-5830	271	3	regard	regard	NOUN
bam-5830	271	4	,	,	PUNCT
bam-5830	271	5	muscle	muscle	NOUN
bam-5830	271	6	perk	perk	NOUN
bam-5830	271	7	levels	level	NOUN
bam-5830	271	8	were	be	AUX
bam-5830	271	9	significantly	significantly	ADV
bam-5830	271	10	lower	low	ADJ
bam-5830	271	11	in	in	ADP
bam-5830	271	12	tg	tg	PROPN
bam-5830	271	13	tumor	tumor	NOUN
bam-5830	271	14	bearers	bearer	NOUN
bam-5830	271	15	than	than	ADP
bam-5830	271	16	in	in	ADP
bam-5830	271	17	wt	wt	PROPN
bam-5830	271	18	c26	c26	NOUN
bam-5830	271	19	hosts	host	NOUN
bam-5830	271	20	.	.	PUNCT
bam-5830	272	1	in	in	ADP
bam-5830	272	2	conclusion	conclusion	NOUN
bam-5830	272	3	,	,	PUNCT
bam-5830	272	4	the	the	DET
bam-5830	272	5	present	present	ADJ
bam-5830	272	6	study	study	NOUN
bam-5830	272	7	shows	show	VERB
bam-5830	272	8	that	that	SCONJ
bam-5830	272	9	pgc-1α	pgc-1α	NOUN
bam-5830	272	10	overexpression	overexpression	NOUN
bam-5830	272	11	in	in	ADP
bam-5830	272	12	the	the	DET
bam-5830	272	13	regenerating	regenerate	VERB
bam-5830	272	14	muscle	muscle	NOUN
bam-5830	272	15	of	of	ADP
bam-5830	272	16	tumor	tumor	NOUN
bam-5830	272	17	hosts	host	NOUN
bam-5830	272	18	resulted	result	VERB
bam-5830	272	19	in	in	ADP
bam-5830	272	20	improved	improved	ADJ
bam-5830	272	21	mitochondrial	mitochondrial	ADJ
bam-5830	272	22	mass	mass	NOUN
bam-5830	272	23	,	,	PUNCT
bam-5830	272	24	and	and	CCONJ
bam-5830	272	25	likely	likely	ADJ
bam-5830	272	26	,	,	PUNCT
bam-5830	272	27	oxidative	oxidative	ADJ
bam-5830	272	28	capacity	capacity	NOUN
bam-5830	272	29	,	,	PUNCT
bam-5830	272	30	and	and	CCONJ
bam-5830	272	31	in	in	ADP
bam-5830	272	32	reduced	reduced	ADJ
bam-5830	272	33	perk	perk	NOUN
bam-5830	272	34	levels	level	NOUN
bam-5830	272	35	,	,	PUNCT
bam-5830	272	36	however	however	ADV
bam-5830	272	37	without	without	ADP
bam-5830	272	38	obtaining	obtain	VERB
bam-5830	272	39	a	a	DET
bam-5830	272	40	significant	significant	ADJ
bam-5830	272	41	csa	csa	PROPN
bam-5830	272	42	rescue	rescue	NOUN
bam-5830	272	43	.	.	PUNCT
bam-5830	273	1	these	these	DET
bam-5830	273	2	observations	observation	NOUN
bam-5830	273	3	suggest	suggest	VERB
bam-5830	273	4	that	that	SCONJ
bam-5830	273	5	while	while	SCONJ
bam-5830	273	6	pgc1α	pgc1α	PROPN
bam-5830	273	7	overexpression	overexpression	NOUN
bam-5830	273	8	exerts	exert	VERB
bam-5830	273	9	positive	positive	ADJ
bam-5830	273	10	effects	effect	NOUN
bam-5830	273	11	on	on	ADP
bam-5830	273	12	tumor	tumor	NOUN
bam-5830	273	13	-	-	PUNCT
bam-5830	273	14	induced	induce	VERB
bam-5830	273	15	derangements	derangement	NOUN
bam-5830	273	16	at	at	ADP
bam-5830	273	17	the	the	DET
bam-5830	273	18	molecular	molecular	ADJ
bam-5830	273	19	level	level	NOUN
bam-5830	273	20	,	,	PUNCT
bam-5830	273	21	it	it	PRON
bam-5830	273	22	does	do	AUX
bam-5830	273	23	not	not	PART
bam-5830	273	24	appear	appear	VERB
bam-5830	273	25	able	able	ADJ
bam-5830	273	26	to	to	PART
bam-5830	273	27	impinge	impinge	VERB
bam-5830	273	28	on	on	ADP
bam-5830	273	29	the	the	DET
bam-5830	273	30	multifactorial	multifactorial	ADJ
bam-5830	273	31	nature	nature	NOUN
bam-5830	273	32	of	of	ADP
bam-5830	273	33	muscle	muscle	NOUN
bam-5830	273	34	wasting	waste	VERB
bam-5830	273	35	.	.	PUNCT
bam-5830	274	1	1	1	X
bam-5830	274	2	.	.	X
bam-5830	274	3	sandri	sandri	VERB
bam-5830	274	4	et	et	PROPN
bam-5830	274	5	al	al	PROPN
bam-5830	274	6	.	.	PROPN
bam-5830	274	7	,	,	PUNCT
bam-5830	275	1	proc	proc	PROPN
bam-5830	275	2	natl	natl	PROPN
bam-5830	275	3	acad	acad	PROPN
bam-5830	275	4	sci	sci	PROPN
bam-5830	275	5	u	u	PROPN
bam-5830	275	6	s	s	PROPN
bam-5830	275	7	a.	a.	NOUN
bam-5830	275	8	2006	2006	NUM
bam-5830	275	9	oct	oct	NOUN
bam-5830	275	10	31;103(44):16260	31;103(44):16260	PROPN
bam-5830	275	11	-	-	SYM
bam-5830	275	12	5	5	NUM
bam-5830	275	13	.	.	NOUN
bam-5830	275	14	2	2	NUM
bam-5830	275	15	.	.	X
bam-5830	275	16	wenz	wenz	PROPN
bam-5830	275	17	et	et	PROPN
bam-5830	275	18	al	al	PROPN
bam-5830	275	19	.	.	PROPN
bam-5830	275	20	,	,	PUNCT
bam-5830	275	21	proc	proc	PROPN
bam-5830	275	22	natl	natl	PROPN
bam-5830	275	23	acad	acad	PROPN
bam-5830	275	24	sci	sci	PROPN
bam-5830	275	25	u	u	PROPN
bam-5830	275	26	s	s	PROPN
bam-5830	275	27	a.	a.	NOUN
bam-5830	275	28	2009	2009	NUM
bam-5830	275	29	dec	dec	PROPN
bam-5830	275	30	1;106(48):20405	1;106(48):20405	PROPN
bam-5830	275	31	-	-	SYM
bam-5830	275	32	10	10	NUM
bam-5830	275	33	.	.	PUNCT
bam-5830	276	1	3	3	X
bam-5830	276	2	.	.	X
bam-5830	276	3	penna	penna	PROPN
bam-5830	276	4	,	,	PUNCT
bam-5830	276	5	bonetto	bonetto	NOUN
bam-5830	276	6	et	et	PROPN
bam-5830	276	7	al	al	PROPN
bam-5830	276	8	.	.	PROPN
bam-5830	276	9	,	,	PUNCT
bam-5830	276	10	int	int	PROPN
bam-5830	276	11	j	j	PROPN
bam-5830	276	12	cancer	cancer	NOUN
bam-5830	276	13	.	.	PUNCT
bam-5830	277	1	2010	2010	NUM
bam-5830	277	2	oct	oct	NOUN
bam-5830	277	3	1;127(7):1706	1;127(7):1706	PROPN
bam-5830	277	4	-	-	PUNCT
bam-5830	277	5	17	17	NUM
bam-5830	277	6	.	.	PUNCT
bam-5830	277	7	
 	
 	SPACE
bam-5830	278	1	4	4	NUM
bam-5830	278	2	.	.	PUNCT
bam-5830	278	3	penna	penna	PROPN
bam-5830	278	4	et	et	PROPN
bam-5830	278	5	al	al	PROPN
bam-5830	278	6	.	.	PROPN
bam-5830	278	7	,	,	PUNCT
bam-5830	278	8	plos	plos	PROPN
bam-5830	278	9	one	one	NUM
bam-5830	278	10	.	.	PUNCT
bam-5830	279	1	2010	2010	NUM
bam-5830	279	2	oct	oct	NOUN
bam-5830	279	3	27;5(10):e13604	27;5(10):e13604	NUM
bam-5830	279	4	.	.	PUNCT
bam-5830	280	1	*	*	PUNCT
bam-5830	280	2	*	*	PUNCT
bam-5830	280	3	*	*	PUNCT
bam-5830	280	4	*	*	PUNCT
bam-5830	280	5	*	*	PUNCT
bam-5830	280	6	the	the	DET
bam-5830	280	7	activation	activation	NOUN
bam-5830	280	8	of	of	ADP
bam-5830	280	9	the	the	DET
bam-5830	280	10	sdf1	sdf1	PROPN
bam-5830	280	11	/	/	SYM
bam-5830	280	12	cxcr4	cxcr4	NOUN
bam-5830	280	13	pathway	pathway	NOUN
bam-5830	280	14	retards	retard	NOUN
bam-5830	280	15	muscle	muscle	VERB
bam-5830	280	16	atrophy	atrophy	NOUN
bam-5830	280	17	during	during	ADP
bam-5830	280	18	cancer	cancer	NOUN
bam-5830	280	19	cachexia	cachexia	PROPN
bam-5830	280	20	g.b	g.b	PROPN
bam-5830	280	21	.	.	PROPN
bam-5830	280	22	martinelli	martinelli	PROPN
bam-5830	280	23	1	1	NUM
bam-5830	280	24	,	,	PUNCT
bam-5830	280	25	d.	d.	PROPN
bam-5830	280	26	olivari	olivari	PROPN
bam-5830	280	27	1	1	NUM
bam-5830	280	28	,	,	PUNCT
bam-5830	281	1	l.	l.	PROPN
bam-5830	281	2	talamini	talamini	PROPN
bam-5830	281	3	1	1	NUM
bam-5830	281	4	,	,	PUNCT
bam-5830	281	5	s.h	s.h	PROPN
bam-5830	281	6	.	.	PROPN
bam-5830	281	7	lecker	lecker	NOUN
bam-5830	281	8	2	2	NUM
bam-5830	281	9	,	,	PUNCT
bam-5830	281	10	l.	l.	PROPN
bam-5830	281	11	ottoboni	ottoboni	PROPN
bam-5830	281	12	3	3	NUM
bam-5830	281	13	,	,	PUNCT
bam-5830	281	14	a.	a.	NOUN
bam-5830	281	15	resovi	resovi	PROPN
bam-5830	281	16	4	4	NUM
bam-5830	281	17	,	,	PUNCT
bam-5830	281	18	r.	r.	PROPN
bam-5830	281	19	giavazzi	giavazzi	PROPN
bam-5830	281	20	1	1	NUM
bam-5830	281	21	,	,	PUNCT
bam-5830	281	22	l.	l.	PROPN
bam-5830	281	23	cervo	cervo	PROPN
bam-5830	281	24	,	,	PUNCT
bam-5830	281	25	5	5	NUM
bam-5830	281	26	,	,	PUNCT
bam-5830	281	27	r.	r.	NOUN
bam-5830	281	28	piccirillo	piccirillo	PROPN
bam-5830	281	29	1	1	NUM
bam-5830	281	30	1	1	NUM
bam-5830	281	31	.	.	PUNCT
bam-5830	281	32	oncology	oncology	NOUN
bam-5830	281	33	department	department	NOUN
bam-5830	281	34	,	,	PUNCT
bam-5830	281	35	irccs	irccs	NOUN
bam-5830	281	36	-	-	PUNCT
bam-5830	281	37	mario	mario	NOUN
bam-5830	281	38	negri	negri	PROPN
bam-5830	281	39	research	research	PROPN
bam-5830	281	40	institute	institute	PROPN
bam-5830	281	41	for	for	ADP
bam-5830	281	42	pharmacological	pharmacological	ADJ
bam-5830	281	43	research	research	NOUN
bam-5830	281	44	,	,	PUNCT
bam-5830	281	45	milan	milan	PROPN
bam-5830	281	46	,	,	PUNCT
bam-5830	281	47	italy	italy	PROPN
bam-5830	281	48	;	;	PUNCT
bam-5830	281	49	2	2	X
bam-5830	281	50	.	.	X
bam-5830	281	51	beth	beth	PROPN
bam-5830	281	52	israel	israel	PROPN
bam-5830	281	53	deaconess	deaconess	PROPN
bam-5830	281	54	center	center	PROPN
bam-5830	281	55	,	,	PUNCT
bam-5830	281	56	boston	boston	PROPN
bam-5830	281	57	,	,	PUNCT
bam-5830	281	58	ma	ma	PROPN
bam-5830	281	59	,	,	PUNCT
bam-5830	281	60	usa	usa	PROPN
bam-5830	281	61	;	;	PUNCT
bam-5830	281	62	3	3	X
bam-5830	281	63	.	.	X
bam-5830	281	64	san	san	PROPN
bam-5830	281	65	raffaele	raffaele	PROPN
bam-5830	281	66	scientific	scientific	PROPN
bam-5830	281	67	institute	institute	PROPN
bam-5830	281	68	,	,	PUNCT
bam-5830	281	69	milan	milan	PROPN
bam-5830	281	70	,	,	PUNCT
bam-5830	281	71	italy	italy	PROPN
bam-5830	281	72	;	;	PUNCT
bam-5830	281	73	4	4	X
bam-5830	281	74	.	.	X
bam-5830	281	75	oncology	oncology	NOUN
bam-5830	281	76	department	department	PROPN
bam-5830	281	77	,	,	PUNCT
bam-5830	281	78	tumor	tumor	NOUN
bam-5830	281	79	angiogenesis	angiogenesis	NOUN
bam-5830	281	80	unit	unit	NOUN
bam-5830	281	81	,	,	PUNCT
bam-5830	281	82	irccs	ircc	VERB
bam-5830	281	83	mario	mario	PROPN
bam-5830	281	84	negri	negri	PROPN
bam-5830	281	85	institute	institute	PROPN
bam-5830	281	86	for	for	ADP
bam-5830	281	87	pharmacological	pharmacological	ADJ
bam-5830	281	88	research	research	NOUN
bam-5830	281	89	,	,	PUNCT
bam-5830	281	90	bergamo	bergamo	NOUN
bam-5830	281	91	,	,	PUNCT
bam-5830	281	92	italy	italy	PROPN
bam-5830	281	93	;	;	PUNCT
bam-5830	281	94	5	5	X
bam-5830	281	95	.	.	X
bam-5830	281	96	neuroscience	neuroscience	PROPN
bam-5830	281	97	department	department	PROPN
bam-5830	281	98	,	,	PUNCT
bam-5830	281	99	irccs	ircc	VERB
bam-5830	281	100	mario	mario	PROPN
bam-5830	281	101	negri	negri	PROPN
bam-5830	281	102	institute	institute	PROPN
bam-5830	281	103	for	for	ADP
bam-5830	281	104	pharmacological	pharmacological	ADJ
bam-5830	281	105	research	research	NOUN
bam-5830	281	106	,	,	PUNCT
bam-5830	281	107	milan	milan	PROPN
bam-5830	281	108	,	,	PUNCT
bam-5830	281	109	italy	italy	PROPN
bam-5830	281	110	e	e	PROPN
bam-5830	281	111	-	-	NOUN
bam-5830	281	112	mail	mail	NOUN
bam-5830	281	113	:	:	PUNCT
bam-5830	281	114	giuliabenedetta.martinelli@marionegri.it	giuliabenedetta.martinelli@marionegri.it	NOUN
bam-5830	281	115	cancer	cancer	NOUN
bam-5830	281	116	cachexia	cachexia	PROPN
bam-5830	281	117	is	be	AUX
bam-5830	281	118	a	a	DET
bam-5830	281	119	life	life	NOUN
bam-5830	281	120	-	-	PUNCT
bam-5830	281	121	threatening	threaten	VERB
bam-5830	281	122	syndrome	syndrome	NOUN
bam-5830	281	123	that	that	PRON
bam-5830	281	124	affects	affect	VERB
bam-5830	281	125	most	most	ADJ
bam-5830	281	126	patients	patient	NOUN
bam-5830	281	127	with	with	ADP
bam-5830	281	128	advanced	advanced	ADJ
bam-5830	281	129	cancers	cancer	NOUN
bam-5830	281	130	and	and	CCONJ
bam-5830	281	131	involves	involve	VERB
bam-5830	281	132	severe	severe	ADJ
bam-5830	281	133	body	body	NOUN
bam-5830	281	134	weight	weight	NOUN
bam-5830	281	135	loss	loss	NOUN
bam-5830	281	136	,	,	PUNCT
bam-5830	281	137	with	with	ADP
bam-5830	281	138	rapid	rapid	ADJ
bam-5830	281	139	depletion	depletion	NOUN
bam-5830	281	140	of	of	ADP
bam-5830	281	141	skeletal	skeletal	ADJ
bam-5830	281	142	muscle	muscle	NOUN
bam-5830	281	143	.	.	PUNCT
bam-5830	282	1	no	no	DET
bam-5830	282	2	effective	effective	ADJ
bam-5830	282	3	treatment	treatment	NOUN
bam-5830	282	4	is	be	AUX
bam-5830	282	5	available	available	ADJ
bam-5830	282	6	.	.	PUNCT
bam-5830	283	1	we	we	PRON
bam-5830	283	2	analyzed	analyze	VERB
bam-5830	283	3	microarray	microarray	NOUN
bam-5830	283	4	datasets	dataset	NOUN
bam-5830	283	5	to	to	PART
bam-5830	283	6	identify	identify	VERB
bam-5830	283	7	a	a	DET
bam-5830	283	8	subset	subset	NOUN
bam-5830	283	9	of	of	ADP
bam-5830	283	10	genes	gene	NOUN
bam-5830	283	11	whose	whose	DET
bam-5830	283	12	expression	expression	NOUN
bam-5830	283	13	is	be	AUX
bam-5830	283	14	specifically	specifically	ADV
bam-5830	283	15	altered	alter	VERB
bam-5830	283	16	in	in	ADP
bam-5830	283	17	cachectic	cachectic	ADJ
bam-5830	283	18	muscles	muscle	NOUN
bam-5830	283	19	of	of	ADP
bam-5830	283	20	yoshida	yoshida	PROPN
bam-5830	283	21	hepatoma	hepatoma	NOUN
bam-5830	283	22	-	-	PUNCT
bam-5830	283	23	bearing	bear	VERB
bam-5830	283	24	rodents	rodent	NOUN
bam-5830	283	25	,	,	PUNCT
bam-5830	283	26	but	but	CCONJ
bam-5830	283	27	not	not	PART
bam-5830	283	28	in	in	ADP
bam-5830	283	29	those	those	PRON
bam-5830	283	30	with	with	ADP
bam-5830	283	31	diabetes	diabetes	NOUN
bam-5830	283	32	,	,	PUNCT
bam-5830	283	33	disuse	disuse	NOUN
bam-5830	283	34	,	,	PUNCT
bam-5830	283	35	uremia	uremia	NOUN
bam-5830	283	36	or	or	CCONJ
bam-5830	283	37	fasting	fasting	NOUN
bam-5830	283	38	.	.	PUNCT
bam-5830	284	1	by	by	ADP
bam-5830	284	2	ingenuity	ingenuity	NOUN
bam-5830	284	3	pathways	pathway	NOUN
bam-5830	284	4	analysis	analysis	NOUN
bam-5830	284	5	,	,	PUNCT
bam-5830	284	6	we	we	PRON
bam-5830	284	7	found	find	VERB
bam-5830	284	8	three	three	NUM
bam-5830	284	9	genes	gene	NOUN
bam-5830	284	10	belonging	belong	VERB
bam-5830	284	11	to	to	ADP
bam-5830	284	12	the	the	DET
bam-5830	284	13	cxcr4	cxcr4	NOUN
bam-5830	284	14	pathway	pathway	NOUN
bam-5830	284	15	downregulated	downregulate	VERB
bam-5830	284	16	only	only	ADV
bam-5830	284	17	in	in	ADP
bam-5830	284	18	muscles	muscle	NOUN
bam-5830	284	19	atrophying	atrophy	VERB
bam-5830	284	20	because	because	SCONJ
bam-5830	284	21	of	of	ADP
bam-5830	284	22	cancer	cancer	NOUN
bam-5830	284	23	:	:	PUNCT
bam-5830	284	24	sdf1	sdf1	PROPN
bam-5830	284	25	,	,	PUNCT
bam-5830	284	26	pak1	pak1	PROPN
bam-5830	284	27	and	and	CCONJ
bam-5830	284	28	adcy7	adcy7	PROPN
bam-5830	284	29	.	.	PUNCT
bam-5830	285	1	consistently	consistently	ADV
bam-5830	285	2	,	,	PUNCT
bam-5830	285	3	we	we	PRON
bam-5830	285	4	show	show	VERB
bam-5830	285	5	that	that	SCONJ
bam-5830	285	6	the	the	DET
bam-5830	285	7	expression	expression	NOUN
bam-5830	285	8	of	of	ADP
bam-5830	285	9	all	all	DET
bam-5830	285	10	sdf1	sdf1	PROPN
bam-5830	285	11	isoforms	isoform	NOUN
bam-5830	285	12	declines	decline	NOUN
bam-5830	285	13	also	also	ADV
bam-5830	285	14	in	in	ADP
bam-5830	285	15	tibialis	tibialis	PROPN
bam-5830	285	16	anterior	anterior	ADJ
bam-5830	285	17	from	from	ADP
bam-5830	285	18	cachectic	cachectic	ADJ
bam-5830	285	19	mice	mouse	NOUN
bam-5830	285	20	bearing	bear	VERB
bam-5830	285	21	colon	colon	NOUN
bam-5830	285	22	adenocarcinoma	adenocarcinoma	NOUN
bam-5830	285	23	or	or	CCONJ
bam-5830	285	24	renal	renal	ADJ
bam-5830	285	25	cancer	cancer	NOUN
bam-5830	285	26	and	and	CCONJ
bam-5830	285	27	anti	anti	ADJ
bam-5830	285	28	-	-	ADJ
bam-5830	285	29	cachexia	cachexia	ADJ
bam-5830	285	30	drugs	drug	NOUN
bam-5830	285	31	such	such	ADJ
bam-5830	285	32	as	as	ADP
bam-5830	285	33	sunitinib	sunitinib	NOUN
bam-5830	285	34	restore	restore	VERB
bam-5830	285	35	it	it	PRON
bam-5830	285	36	.	.	PUNCT
bam-5830	286	1	overexpressing	overexpresse	VERB
bam-5830	286	2	genes	gene	NOUN
bam-5830	286	3	of	of	ADP
bam-5830	286	4	this	this	DET
bam-5830	286	5	pathway	pathway	NOUN
bam-5830	286	6	(	(	PUNCT
bam-5830	286	7	i.e.	i.e.	X
bam-5830	286	8	sdf1	sdf1	NOUN
bam-5830	286	9	or	or	CCONJ
bam-5830	286	10	cxcr4	cxcr4	NOUN
bam-5830	286	11	)	)	PUNCT
bam-5830	286	12	in	in	ADP
bam-5830	286	13	cachectic	cachectic	ADJ
bam-5830	286	14	muscles	muscle	NOUN
bam-5830	286	15	increases	increase	VERB
bam-5830	286	16	the	the	DET
bam-5830	286	17	fiber	fiber	NOUN
bam-5830	286	18	area	area	NOUN
bam-5830	286	19	by	by	ADP
bam-5830	286	20	20	20	NUM
bam-5830	286	21	%	%	NOUN
bam-5830	286	22	,	,	PUNCT
bam-5830	286	23	partially	partially	ADV
bam-5830	286	24	protecting	protect	VERB
bam-5830	286	25	them	they	PRON
bam-5830	286	26	from	from	ADP
bam-5830	286	27	wasting	waste	VERB
bam-5830	286	28	.	.	PUNCT
bam-5830	287	1	the	the	DET
bam-5830	287	2	mechanisms	mechanism	NOUN
bam-5830	287	3	behind	behind	ADP
bam-5830	287	4	this	this	DET
bam-5830	287	5	muscle	muscle	NOUN
bam-5830	287	6	preservation	preservation	NOUN
bam-5830	287	7	during	during	ADP
bam-5830	287	8	cachexia	cachexia	PROPN
bam-5830	287	9	include	include	VERB
bam-5830	287	10	both	both	DET
bam-5830	287	11	reduced	reduce	VERB
bam-5830	287	12	degradation	degradation	NOUN
bam-5830	287	13	of	of	ADP
bam-5830	287	14	long	long	ADV
bam-5830	287	15	-	-	PUNCT
bam-5830	287	16	lived	live	VERB
bam-5830	287	17	proteins	protein	NOUN
bam-5830	287	18	,	,	PUNCT
bam-5830	287	19	by	by	ADP
bam-5830	287	20	either	either	CCONJ
bam-5830	287	21	sdf1α	sdf1α	PROPN
bam-5830	287	22	or	or	CCONJ
bam-5830	287	23	sdf1β	sdf1β	PROPN
bam-5830	287	24	on	on	ADP
bam-5830	287	25	atrophying	atrophy	VERB
bam-5830	287	26	myotubes	myotube	NOUN
bam-5830	287	27	,	,	PUNCT
bam-5830	287	28	and	and	CCONJ
bam-5830	287	29	increased	increase	VERB
bam-5830	287	30	protein	protein	NOUN
bam-5830	287	31	synthesis	synthesis	NOUN
bam-5830	287	32	,	,	PUNCT
bam-5830	287	33	mainly	mainly	ADV
bam-5830	287	34	by	by	ADP
bam-5830	287	35	sdf1α	sdf1α	PROPN
bam-5830	287	36	.	.	PUNCT
bam-5830	288	1	however	however	ADV
bam-5830	288	2	,	,	PUNCT
bam-5830	288	3	inhibiting	inhibit	VERB
bam-5830	288	4	cxcr4	cxcr4	NOUN
bam-5830	288	5	signaling	signal	VERB
bam-5830	288	6	with	with	ADP
bam-5830	288	7	the	the	DET
bam-5830	288	8	antagonist	antagonist	NOUN
bam-5830	288	9	amd3100	amd3100	NOUN
bam-5830	288	10	does	do	AUX
bam-5830	288	11	not	not	PART
bam-5830	288	12	affect	affect	VERB
bam-5830	288	13	protein	protein	NOUN
bam-5830	288	14	homeostasis	homeostasis	NOUN
bam-5830	288	15	in	in	ADP
bam-5830	288	16	atrophying	atrophy	VERB
bam-5830	288	17	myotubes	myotube	NOUN
bam-5830	288	18	at	at	ADV
bam-5830	288	19	all	all	ADV
bam-5830	288	20	,	,	PUNCT
bam-5830	288	21	whereas	whereas	SCONJ
bam-5830	288	22	normal	normal	ADJ
bam-5830	288	23	myotubes	myotube	NOUN
bam-5830	288	24	treated	treat	VERB
bam-5830	288	25	with	with	ADP
bam-5830	288	26	amd3100	amd3100	PROPN
bam-5830	288	27	display	display	PROPN
bam-5830	288	28	decreased	decrease	VERB
bam-5830	288	29	diameter	diameter	NOUN
bam-5830	288	30	in	in	ADP
bam-5830	288	31	a	a	DET
bam-5830	288	32	timeand	timeand	NOUN
bam-5830	288	33	dose	dose	NOUN
bam-5830	288	34	-	-	PUNCT
bam-5830	288	35	dependent	dependent	ADJ
bam-5830	288	36	manner	manner	NOUN
bam-5830	288	37	,	,	PUNCT
bam-5830	288	38	until	until	ADP
bam-5830	288	39	a	a	DET
bam-5830	288	40	plateau	plateau	NOUN
bam-5830	288	41	.	.	PUNCT
bam-5830	289	1	this	this	PRON
bam-5830	289	2	further	far	ADV
bam-5830	289	3	confirms	confirm	VERB
bam-5830	289	4	the	the	DET
bam-5830	289	5	involvement	involvement	NOUN
bam-5830	289	6	of	of	ADP
bam-5830	289	7	a	a	DET
bam-5830	289	8	saturable	saturable	ADJ
bam-5830	289	9	pathway	pathway	NOUN
bam-5830	289	10	(	(	PUNCT
bam-5830	289	11	i.e.	i.e.	X
bam-5830	289	12	cxcr4	cxcr4	NOUN
bam-5830	289	13	)	)	PUNCT
bam-5830	289	14	.	.	PUNCT
bam-5830	290	1	overall	overall	ADV
bam-5830	290	2	,	,	PUNCT
bam-5830	290	3	these	these	DET
bam-5830	290	4	findings	finding	NOUN
bam-5830	290	5	support	support	VERB
bam-5830	290	6	the	the	DET
bam-5830	290	7	idea	idea	NOUN
bam-5830	290	8	that	that	SCONJ
bam-5830	290	9	activating	activate	VERB
bam-5830	290	10	the	the	DET
bam-5830	290	11	cxcr4	cxcr4	NOUN
bam-5830	290	12	pathway	pathway	NOUN
bam-5830	290	13	in	in	ADP
bam-5830	290	14	muscle	muscle	NOUN
bam-5830	290	15	suppresses	suppress	VERB
bam-5830	290	16	the	the	DET
bam-5830	290	17	deleterious	deleterious	ADJ
bam-5830	290	18	wasting	wasting	NOUN
bam-5830	290	19	associated	associate	VERB
bam-5830	290	20	with	with	ADP
bam-5830	290	21	cancer	cancer	NOUN
bam-5830	290	22	.	.	PUNCT
bam-5830	291	1	*	*	PUNCT
bam-5830	292	1	*	*	PUNCT
bam-5830	292	2	*	*	PUNCT
bam-5830	292	3	*	*	PUNCT
bam-5830	292	4	*	*	NOUN
bam-5830	292	5	role	role	NOUN
bam-5830	292	6	of	of	ADP
bam-5830	292	7	the	the	DET
bam-5830	292	8	apelinergic	apelinergic	ADJ
bam-5830	292	9	pathway	pathway	NOUN
bam-5830	292	10	in	in	ADP
bam-5830	292	11	colon	colon	NOUN
bam-5830	292	12	adenocarcinoma	adenocarcinoma	NOUN
bam-5830	292	13	-	-	PUNCT
bam-5830	292	14	induced	induce	VERB
bam-5830	292	15	muscle	muscle	NOUN
bam-5830	292	16	wasting	waste	VERB
bam-5830	292	17	d.	d.	PROPN
bam-5830	292	18	olivari	olivari	PROPN
bam-5830	292	19	1	1	NUM
bam-5830	292	20	,	,	PUNCT
bam-5830	292	21	g.	g.	PROPN
bam-5830	292	22	b.	b.	PROPN
bam-5830	292	23	martinelli	martinelli	PROPN
bam-5830	292	24	1	1	NUM
bam-5830	292	25	,	,	PUNCT
bam-5830	292	26	a.	a.	PROPN
bam-5830	292	27	re	re	PROPN
bam-5830	292	28	cecconi	cecconi	PROPN
bam-5830	292	29	1	1	NUM
bam-5830	292	30	,	,	PUNCT
bam-5830	292	31	l.	l.	PROPN
bam-5830	292	32	talamini	talamini	PROPN
bam-5830	292	33	1	1	NUM
bam-5830	292	34	,	,	PUNCT
bam-5830	292	35	f.	f.	PROPN
bam-5830	292	36	cerruti	cerruti	PROPN
bam-5830	292	37	2	2	NUM
bam-5830	292	38	,	,	PUNCT
bam-5830	292	39	p.	p.	NOUN
bam-5830	292	40	cascio	cascio	NOUN
bam-5830	292	41	2	2	NUM
bam-5830	292	42	,	,	PUNCT
bam-5830	292	43	r.	r.	NOUN
bam-5830	292	44	piccirillo	piccirillo	PROPN
bam-5830	292	45	1	1	NUM
bam-5830	292	46	1	1	NUM
bam-5830	292	47	.	.	PUNCT
bam-5830	292	48	oncology	oncology	NOUN
bam-5830	292	49	department	department	NOUN
bam-5830	292	50	,	,	PUNCT
bam-5830	292	51	irccs	irccs	NOUN
bam-5830	292	52	-	-	PUNCT
bam-5830	292	53	mario	mario	NOUN
bam-5830	292	54	negri	negri	PROPN
bam-5830	292	55	research	research	PROPN
bam-5830	292	56	institute	institute	PROPN
bam-5830	292	57	for	for	ADP
bam-5830	292	58	pharmacological	pharmacological	ADJ
bam-5830	292	59	research	research	NOUN
bam-5830	292	60	,	,	PUNCT
bam-5830	292	61	milan	milan	PROPN
bam-5830	292	62	,	,	PUNCT
bam-5830	292	63	italy	italy	PROPN
bam-5830	292	64	;	;	PUNCT
bam-5830	292	65	2	2	X
bam-5830	292	66	.	.	X
bam-5830	292	67	veterinary	veterinary	ADJ
bam-5830	292	68	sciences	sciences	PROPN
bam-5830	292	69	,	,	PUNCT
bam-5830	292	70	turin	turin	PROPN
bam-5830	292	71	university	university	PROPN
bam-5830	292	72	,	,	PUNCT
bam-5830	292	73	turin	turin	PROPN
bam-5830	292	74	,	,	PUNCT
bam-5830	292	75	italy	italy	PROPN
bam-5830	292	76	e	e	PROPN
bam-5830	292	77	-	-	NOUN
bam-5830	292	78	mail	mail	NOUN
bam-5830	292	79	:	:	PUNCT
bam-5830	292	80	davide.olivari@marionegri.it	davide.olivari@marionegri.it	VERB
bam-5830	292	81	cancer	cancer	NOUN
bam-5830	292	82	cachexia	cachexia	PROPN
bam-5830	292	83	is	be	AUX
bam-5830	292	84	a	a	DET
bam-5830	292	85	systemic	systemic	ADJ
bam-5830	292	86	syndrome	syndrome	NOUN
bam-5830	292	87	that	that	PRON
bam-5830	292	88	consists	consist	VERB
bam-5830	292	89	of	of	ADP
bam-5830	292	90	a	a	DET
bam-5830	292	91	dramatic	dramatic	ADJ
bam-5830	292	92	weight	weight	NOUN
bam-5830	292	93	loss	loss	NOUN
bam-5830	292	94	with	with	ADP
bam-5830	292	95	rapid	rapid	ADJ
bam-5830	292	96	muscle	muscle	NOUN
bam-5830	292	97	depletion	depletion	NOUN
bam-5830	292	98	due	due	ADP
bam-5830	292	99	to	to	ADP
bam-5830	292	100	enhanced	enhance	VERB
bam-5830	292	101	protein	protein	NOUN
bam-5830	292	102	degradation	degradation	NOUN
bam-5830	292	103	,	,	PUNCT
bam-5830	292	104	irrespective	irrespective	ADV
bam-5830	292	105	of	of	ADP
bam-5830	292	106	food	food	NOUN
bam-5830	292	107	intake	intake	NOUN
bam-5830	292	108	.	.	PUNCT
bam-5830	293	1	remarkably	remarkably	ADV
bam-5830	293	2	,	,	PUNCT
bam-5830	293	3	50	50	NUM
bam-5830	293	4	%	%	NOUN
bam-5830	293	5	of	of	ADP
bam-5830	293	6	advanced	advanced	ADJ
bam-5830	293	7	cancer	cancer	NOUN
bam-5830	293	8	patients	patient	NOUN
bam-5830	293	9	are	be	AUX
bam-5830	293	10	affected	affect	VERB
bam-5830	293	11	by	by	ADP
bam-5830	293	12	cachexia	cachexia	PROPN
bam-5830	293	13	,	,	PUNCT
bam-5830	293	14	which	which	PRON
bam-5830	293	15	accounts	account	VERB
bam-5830	293	16	for	for	ADP
bam-5830	293	17	approximately	approximately	ADV
bam-5830	293	18	20	20	NUM
bam-5830	293	19	%	%	NOUN
bam-5830	293	20	of	of	ADP
bam-5830	293	21	cancer	cancer	NOUN
bam-5830	293	22	deaths	death	NOUN
bam-5830	293	23	.	.	PUNCT
bam-5830	294	1	no	no	DET
bam-5830	294	2	therapy	therapy	NOUN
bam-5830	294	3	is	be	AUX
bam-5830	294	4	available	available	ADJ
bam-5830	294	5	.	.	PUNCT
bam-5830	295	1	interestingly	interestingly	ADV
bam-5830	295	2	,	,	PUNCT
bam-5830	295	3	females	female	NOUN
bam-5830	295	4	are	be	AUX
bam-5830	295	5	more	more	ADV
bam-5830	295	6	resistant	resistant	ADJ
bam-5830	295	7	to	to	ADP
bam-5830	295	8	cancer	cancer	NOUN
bam-5830	295	9	cachexia	cachexia	NOUN
bam-5830	295	10	than	than	ADP
bam-5830	295	11	males	male	NOUN
bam-5830	295	12	.	.	PUNCT
bam-5830	296	1	we	we	PRON
bam-5830	296	2	analyzed	analyze	VERB
bam-5830	296	3	previous	previous	ADJ
bam-5830	296	4	microarray	microarray	NOUN
bam-5830	296	5	datasets	dataset	NOUN
bam-5830	296	6	to	to	PART
bam-5830	296	7	identify	identify	VERB
bam-5830	296	8	genes	gene	NOUN
bam-5830	296	9	whose	whose	DET
bam-5830	296	10	expression	expression	NOUN
bam-5830	296	11	is	be	AUX
bam-5830	296	12	specifically	specifically	ADV
bam-5830	296	13	altered	alter	VERB
bam-5830	296	14	in	in	ADP
bam-5830	296	15	cachectic	cachectic	ADJ
bam-5830	296	16	muscles	muscle	NOUN
bam-5830	296	17	of	of	ADP
bam-5830	296	18	yoshida	yoshida	PROPN
bam-5830	296	19	hepatoma	hepatoma	NOUN
bam-5830	296	20	-	-	PUNCT
bam-5830	296	21	bearing	bear	VERB
bam-5830	296	22	male	male	ADJ
bam-5830	296	23	rodents	rodent	NOUN
bam-5830	296	24	.	.	PUNCT
bam-5830	297	1	among	among	ADP
bam-5830	297	2	these	these	DET
bam-5830	297	3	genes	gene	NOUN
bam-5830	297	4	,	,	PUNCT
bam-5830	297	5	we	we	PRON
bam-5830	297	6	found	find	VERB
bam-5830	297	7	that	that	SCONJ
bam-5830	297	8	apelin	apelin	PROPN
bam-5830	297	9	was	be	AUX
bam-5830	297	10	drastically	drastically	ADV
bam-5830	297	11	downregulated	downregulate	VERB
bam-5830	297	12	to	to	ADP
bam-5830	297	13	8	8	NUM
bam-5830	297	14	%	%	NOUN
bam-5830	297	15	of	of	ADP
bam-5830	297	16	controls	control	NOUN
bam-5830	297	17	in	in	ADP
bam-5830	297	18	cachectic	cachectic	ADJ
bam-5830	297	19	gastrocnemius	gastrocnemius	NOUN
bam-5830	297	20	muscles	muscle	NOUN
bam-5830	297	21	(	(	PUNCT
bam-5830	297	22	with	with	ADP
bam-5830	297	23	14	14	NUM
bam-5830	297	24	%	%	NOUN
bam-5830	297	25	of	of	ADP
bam-5830	297	26	weight	weight	NOUN
bam-5830	297	27	loss	loss	NOUN
bam-5830	297	28	)	)	PUNCT
bam-5830	297	29	from	from	ADP
bam-5830	297	30	male	male	ADJ
bam-5830	297	31	rats	rat	NOUN
bam-5830	297	32	bearing	bear	VERB
bam-5830	297	33	yoshida	yoshida	PROPN
bam-5830	297	34	hepatoma	hepatoma	NOUN
bam-5830	297	35	for	for	ADP
bam-5830	297	36	5	5	NUM
bam-5830	297	37	days	day	NOUN
bam-5830	297	38	.	.	PUNCT
bam-5830	298	1	we	we	PRON
bam-5830	298	2	confirmed	confirm	VERB
bam-5830	298	3	by	by	ADP
bam-5830	298	4	q	q	NOUN
bam-5830	298	5	-	-	PUNCT
bam-5830	298	6	pcr	pcr	ADJ
bam-5830	298	7	that	that	SCONJ
bam-5830	298	8	apelin	apelin	PROPN
bam-5830	298	9	was	be	AUX
bam-5830	298	10	downregulated	downregulate	VERB
bam-5830	298	11	to	to	ADP
bam-5830	298	12	45	45	NUM
bam-5830	298	13	%	%	NOUN
bam-5830	298	14	and	and	CCONJ
bam-5830	298	15	2	2	NUM
bam-5830	298	16	%	%	NOUN
bam-5830	298	17	of	of	ADP
bam-5830	298	18	controls	control	NOUN
bam-5830	298	19	also	also	ADV
bam-5830	298	20	in	in	ADP
bam-5830	298	21	tibialis	tibialis	PROPN
bam-5830	298	22	anterior	anterior	NOUN
bam-5830	298	23	(	(	PUNCT
bam-5830	298	24	ta	ta	NOUN
bam-5830	298	25	)	)	PUNCT
bam-5830	298	26	muscles	muscle	NOUN
bam-5830	298	27	in	in	ADP
bam-5830	298	28	lewis	lewis	PROPN
bam-5830	298	29	lung	lung	NOUN
bam-5830	298	30	carcinoma	carcinoma	NOUN
bam-5830	298	31	and	and	CCONJ
bam-5830	298	32	in	in	ADP
bam-5830	298	33	colon	colon	NOUN
bam-5830	298	34	adenocarcinoma	adenocarcinoma	NOUN
bam-5830	298	35	26	26	NUM
bam-5830	298	36	(	(	PUNCT
bam-5830	298	37	c26)-bearing	c26)-beare	VERB
bam-5830	298	38	mice	mouse	NOUN
bam-5830	298	39	,	,	PUNCT
bam-5830	298	40	respectively	respectively	ADV
bam-5830	298	41	.	.	PUNCT
bam-5830	299	1	moreover	moreover	ADV
bam-5830	299	2	,	,	PUNCT
bam-5830	299	3	in	in	ADP
bam-5830	299	4	ta	ta	PROPN
bam-5830	299	5	from	from	ADP
bam-5830	299	6	c26	c26	NOUN
bam-5830	299	7	-	-	PUNCT
bam-5830	299	8	bearing	bear	VERB
bam-5830	299	9	mice	mouse	NOUN
bam-5830	299	10	also	also	ADV
bam-5830	299	11	the	the	DET
bam-5830	299	12	expression	expression	NOUN
bam-5830	299	13	of	of	ADP
bam-5830	299	14	apelin	apelin	PROPN
bam-5830	299	15	receptor	receptor	NOUN
bam-5830	299	16	(	(	PUNCT
bam-5830	299	17	apj	apj	PROPN
bam-5830	299	18	)	)	PUNCT
bam-5830	299	19	,	,	PUNCT
bam-5830	299	20	a	a	DET
bam-5830	299	21	member	member	NOUN
bam-5830	299	22	of	of	ADP
bam-5830	299	23	gprotein	gprotein	PROPN
bam-5830	299	24	coupled	couple	VERB
bam-5830	299	25	receptors	receptor	NOUN
bam-5830	299	26	,	,	PUNCT
bam-5830	299	27	was	be	AUX
bam-5830	299	28	reduced	reduce	VERB
bam-5830	299	29	to	to	ADP
bam-5830	299	30	16	16	NUM
bam-5830	299	31	%	%	NOUN
bam-5830	299	32	.	.	PUNCT
bam-5830	300	1	q	q	ADJ
bam-5830	300	2	-	-	ADJ
bam-5830	300	3	pcr	pcr	ADJ
bam-5830	300	4	analysis	analysis	NOUN
bam-5830	300	5	further	far	ADV
bam-5830	300	6	confirmed	confirm	VERB
bam-5830	300	7	that	that	SCONJ
bam-5830	300	8	apelin	apelin	PROPN
bam-5830	300	9	downregulation	downregulation	NOUN
bam-5830	300	10	occurred	occur	VERB
bam-5830	300	11	at	at	ADP
bam-5830	300	12	all	all	DET
bam-5830	300	13	stages	stage	NOUN
bam-5830	300	14	of	of	ADP
bam-5830	300	15	cancer	cancer	NOUN
bam-5830	300	16	cachexia	cachexia	NOUN
bam-5830	300	17	of	of	ADP
bam-5830	300	18	c26	c26	NOUN
bam-5830	300	19	-	-	PUNCT
bam-5830	300	20	bearing	bear	VERB
bam-5830	300	21	male	male	ADJ
bam-5830	300	22	mice	mouse	NOUN
bam-5830	300	23	,	,	PUNCT
bam-5830	300	24	while	while	SCONJ
bam-5830	300	25	the	the	DET
bam-5830	300	26	expression	expression	NOUN
bam-5830	300	27	of	of	ADP
bam-5830	300	28	apj	apj	PROPN
bam-5830	300	29	was	be	AUX
bam-5830	300	30	significantly	significantly	ADV
bam-5830	300	31	reduced	reduce	VERB
bam-5830	300	32	to	to	ADP
bam-5830	300	33	30	30	NUM
bam-5830	300	34	%	%	NOUN
bam-5830	300	35	of	of	ADP
bam-5830	300	36	controls	control	NOUN
bam-5830	300	37	only	only	ADV
bam-5830	300	38	in	in	ADP
bam-5830	300	39	early	early	ADJ
bam-5830	300	40	cachectic	cachectic	ADJ
bam-5830	300	41	mice	mouse	NOUN
bam-5830	300	42	with	with	ADP
bam-5830	300	43	less	less	ADJ
bam-5830	300	44	than	than	ADP
bam-5830	300	45	14	14	NUM
bam-5830	300	46	%	%	NOUN
bam-5830	300	47	of	of	ADP
bam-5830	300	48	body	body	NOUN
bam-5830	300	49	weight	weight	NOUN
bam-5830	300	50	loss	loss	NOUN
bam-5830	300	51	.	.	PUNCT
bam-5830	301	1	since	since	SCONJ
bam-5830	301	2	apelin	apelin	PROPN
bam-5830	301	3	is	be	AUX
bam-5830	301	4	expressed	express	VERB
bam-5830	301	5	on	on	ADP
bam-5830	301	6	x	x	PART
bam-5830	301	7	chromosome	chromosome	VERB
bam-5830	301	8	both	both	PRON
bam-5830	301	9	in	in	ADP
bam-5830	301	10	humans	human	NOUN
bam-5830	301	11	and	and	CCONJ
bam-5830	301	12	mice	mouse	NOUN
bam-5830	301	13	and	and	CCONJ
bam-5830	301	14	it	it	PRON
bam-5830	301	15	is	be	AUX
bam-5830	301	16	not	not	PART
bam-5830	301	17	downregulated	downregulate	VERB
bam-5830	301	18	in	in	ADP
bam-5830	301	19	muscles	muscle	NOUN
bam-5830	301	20	from	from	ADP
bam-5830	301	21	c26	c26	NOUN
bam-5830	301	22	-	-	PUNCT
bam-5830	301	23	bearing	bear	VERB
bam-5830	301	24	female	female	ADJ
bam-5830	301	25	mice	mouse	NOUN
bam-5830	301	26	,	,	PUNCT
bam-5830	301	27	we	we	PRON
bam-5830	301	28	believe	believe	VERB
bam-5830	301	29	that	that	SCONJ
bam-5830	301	30	apelin	apelin	PROPN
bam-5830	301	31	could	could	AUX
bam-5830	301	32	be	be	AUX
bam-5830	301	33	a	a	DET
bam-5830	301	34	good	good	ADJ
bam-5830	301	35	candidate	candidate	NOUN
bam-5830	301	36	to	to	PART
bam-5830	301	37	explain	explain	VERB
bam-5830	301	38	the	the	DET
bam-5830	301	39	gender	gender	NOUN
bam-5830	301	40	difference	difference	NOUN
bam-5830	301	41	of	of	ADP
bam-5830	301	42	cancer	cancer	NOUN
bam-5830	301	43	cachexia	cachexia	NOUN
bam-5830	301	44	.	.	PUNCT
bam-5830	302	1	*	*	PUNCT
bam-5830	302	2	*	*	PUNCT
bam-5830	302	3	*	*	PUNCT
bam-5830	302	4	*	*	PUNCT
bam-5830	302	5	*	*	ADJ
bam-5830	302	6	tumor	tumor	NOUN
bam-5830	302	7	-	-	PUNCT
bam-5830	302	8	derived	derive	VERB
bam-5830	302	9	microvesicles	microvesicle	NOUN
bam-5830	302	10	:	:	PUNCT
bam-5830	302	11	new	new	ADJ
bam-5830	302	12	players	player	NOUN
bam-5830	302	13	in	in	ADP
bam-5830	302	14	cancerinduced	cancerinduce	VERB
bam-5830	302	15	muscle	muscle	NOUN
bam-5830	302	16	wasting	waste	VERB
bam-5830	302	17	f.	f.	PROPN
bam-5830	302	18	pin	pin	PROPN
bam-5830	302	19	1,2,3	1,2,3	NUM
bam-5830	302	20	,	,	PUNCT
bam-5830	302	21	r.	r.	PROPN
bam-5830	302	22	ballarò	ballarò	PROPN
bam-5830	302	23	1	1	NUM
bam-5830	302	24	,	,	PUNCT
bam-5830	302	25	f.	f.	PROPN
bam-5830	302	26	penna	penna	PROPN
bam-5830	302	27	1,3	1,3	PROPN
bam-5830	302	28	,	,	PUNCT
bam-5830	302	29	m.	m.	NOUN
bam-5830	302	30	beltrà	beltrà	PROPN
bam-5830	302	31	bach	bach	PROPN
bam-5830	302	32	1	1	NUM
bam-5830	302	33	,	,	PUNCT
bam-5830	302	34	d.c	d.c	PROPN
bam-5830	302	35	.	.	PROPN
bam-5830	302	36	guttridge	guttridge	PROPN
bam-5830	302	37	2	2	NUM
bam-5830	302	38	,	,	PUNCT
bam-5830	302	39	p.	p.	NOUN
bam-5830	302	40	costelli	costelli	NOUN
bam-5830	303	1	1	1	NUM
bam-5830	303	2	1	1	X
bam-5830	303	3	.	.	PUNCT
bam-5830	304	1	department	department	NOUN
bam-5830	304	2	of	of	ADP
bam-5830	304	3	clinical	clinical	ADJ
bam-5830	304	4	and	and	CCONJ
bam-5830	304	5	biological	biological	ADJ
bam-5830	304	6	sciences	science	NOUN
bam-5830	304	7	,	,	PUNCT
bam-5830	304	8	experimental	experimental	ADJ
bam-5830	304	9	medicine	medicine	NOUN
bam-5830	304	10	and	and	CCONJ
bam-5830	304	11	clinical	clinical	ADJ
bam-5830	304	12	pathology	pathology	NOUN
bam-5830	304	13	unit	unit	NOUN
bam-5830	304	14	,	,	PUNCT
bam-5830	304	15	university	university	PROPN
bam-5830	304	16	of	of	ADP
bam-5830	304	17	torino	torino	PROPN
bam-5830	304	18	,	,	PUNCT
bam-5830	304	19	italy	italy	PROPN
bam-5830	304	20	;	;	PUNCT
bam-5830	304	21	2	2	X
bam-5830	304	22	.	.	X
bam-5830	304	23	human	human	ADJ
bam-5830	304	24	cancer	cancer	NOUN
bam-5830	304	25	genetics	genetics	PROPN
bam-5830	304	26	program	program	NOUN
bam-5830	304	27	,	,	PUNCT
bam-5830	304	28	department	department	NOUN
bam-5830	304	29	of	of	ADP
bam-5830	304	30	molecular	molecular	ADJ
bam-5830	304	31	virology	virology	NOUN
bam-5830	304	32	,	,	PUNCT
bam-5830	304	33	immunology	immunology	NOUN
bam-5830	304	34	and	and	CCONJ
bam-5830	304	35	medical	medical	ADJ
bam-5830	304	36	genetics	genetic	NOUN
bam-5830	304	37	,	,	PUNCT
bam-5830	304	38	the	the	DET
bam-5830	304	39	ohio	ohio	PROPN
bam-5830	304	40	state	state	PROPN
bam-5830	304	41	university	university	PROPN
bam-5830	304	42	,	,	PUNCT
bam-5830	304	43	columbus	columbus	PROPN
bam-5830	304	44	(	(	PUNCT
bam-5830	304	45	oh	oh	INTJ
bam-5830	304	46	)	)	PUNCT
bam-5830	304	47	,	,	PUNCT
bam-5830	304	48	usa	usa	PROPN
bam-5830	304	49	;	;	PUNCT
bam-5830	304	50	3.interuniversitary	3.interuniversitary	NUM
bam-5830	304	51	institute	institute	NOUN
bam-5830	304	52	of	of	ADP
bam-5830	304	53	myology	myology	NOUN
bam-5830	304	54	,	,	PUNCT
bam-5830	304	55	italy	italy	PROPN
bam-5830	304	56	e	e	PROPN
bam-5830	304	57	-	-	NOUN
bam-5830	304	58	mail	mail	NOUN
bam-5830	304	59	:	:	PUNCT
bam-5830	304	60	fabrizio.pin@unito.it	fabrizio.pin@unito.it	VERB
bam-5830	304	61	cachexia	cachexia	PROPN
bam-5830	304	62	is	be	AUX
bam-5830	304	63	a	a	DET
bam-5830	304	64	syndrome	syndrome	NOUN
bam-5830	304	65	frequently	frequently	ADV
bam-5830	304	66	occurring	occur	VERB
bam-5830	304	67	in	in	ADP
bam-5830	304	68	cancer	cancer	NOUN
bam-5830	304	69	patients	patient	NOUN
bam-5830	304	70	.	.	PUNCT
bam-5830	305	1	it	it	PRON
bam-5830	305	2	is	be	AUX
bam-5830	305	3	characterized	characterize	VERB
bam-5830	305	4	by	by	ADP
bam-5830	305	5	body	body	NOUN
bam-5830	305	6	and	and	CCONJ
bam-5830	305	7	skeletal	skeletal	ADJ
bam-5830	305	8	muscle	muscle	NOUN
bam-5830	305	9	wasting	waste	VERB
bam-5830	305	10	and	and	CCONJ
bam-5830	305	11	by	by	ADP
bam-5830	305	12	metabolic	metabolic	NOUN
bam-5830	305	13	abnormalities	abnormality	NOUN
bam-5830	305	14	.	.	PUNCT
bam-5830	306	1	these	these	DET
bam-5830	306	2	latter	latter	ADJ
bam-5830	306	3	are	be	AUX
bam-5830	306	4	mediated	mediate	VERB
bam-5830	306	5	,	,	PUNCT
bam-5830	306	6	partially	partially	ADV
bam-5830	306	7	at	at	ADP
bam-5830	306	8	least	least	ADJ
bam-5830	306	9	,	,	PUNCT
bam-5830	306	10	by	by	ADP
bam-5830	306	11	humoral	humoral	ADJ
bam-5830	306	12	factors	factor	NOUN
bam-5830	306	13	.	.	PUNCT
bam-5830	307	1	energy	energy	NOUN
bam-5830	307	2	balance	balance	NOUN
bam-5830	307	3	perturbations	perturbation	NOUN
bam-5830	307	4	also	also	ADV
bam-5830	307	5	contribute	contribute	VERB
bam-5830	307	6	to	to	ADP
bam-5830	307	7	the	the	DET
bam-5830	307	8	onset	onset	NOUN
bam-5830	307	9	of	of	ADP
bam-5830	307	10	cachexia	cachexia	NOUN
bam-5830	307	11	.	.	PUNCT
bam-5830	308	1	abstracts	abstract	NOUN
bam-5830	308	2	of	of	ADP
bam-5830	308	3	the	the	DET
bam-5830	308	4	xii	xii	PROPN
bam-5830	308	5	iim	iim	NOUN
bam-5830	308	6	myology	myology	NOUN
bam-5830	308	7	meeting	meeting	NOUN
bam-5830	308	8	october	october	PROPN
bam-5830	308	9	1–4	1–4	PROPN
bam-5830	308	10	,	,	PUNCT
bam-5830	308	11	2015	2015	NUM
bam-5830	308	12	eur	eur	PROPN
bam-5830	308	13	j	j	PROPN
bam-5830	308	14	transl	transl	PROPN
bam-5830	308	15	myol	myol	PROPN
bam-5830	308	16	basic	basic	ADJ
bam-5830	308	17	appl	appl	NOUN
bam-5830	308	18	myol	myol	NOUN
bam-5830	308	19	2016	2016	NUM
bam-5830	308	20	;	;	PUNCT
bam-5830	308	21	26	26	NUM
bam-5830	308	22	(	(	PUNCT
bam-5830	308	23	1):2	1):2	NUM
bam-5830	308	24	-	-	SYM
bam-5830	308	25	24	24	NUM
bam-5830	308	26	this	this	DET
bam-5830	308	27	article	article	NOUN
bam-5830	308	28	is	be	AUX
bam-5830	308	29	distributed	distribute	VERB
bam-5830	308	30	under	under	ADP
bam-5830	308	31	the	the	DET
bam-5830	308	32	terms	term	NOUN
bam-5830	308	33	of	of	ADP
bam-5830	308	34	the	the	DET
bam-5830	308	35	creative	creative	ADJ
bam-5830	308	36	commons	common	NOUN
bam-5830	308	37	attribution	attribution	NOUN
bam-5830	308	38	noncommercial	noncommercial	ADJ
bam-5830	308	39	license	license	NOUN
bam-5830	308	40	(	(	PUNCT
bam-5830	308	41	cc	cc	NOUN
bam-5830	308	42	by	by	ADP
bam-5830	308	43	-	-	PUNCT
bam-5830	308	44	nc	nc	PROPN
bam-5830	308	45	4.0	4.0	NUM
bam-5830	308	46	)	)	PUNCT
bam-5830	308	47	which	which	PRON
bam-5830	308	48	permits	permit	VERB
bam-5830	308	49	any	any	DET
bam-5830	308	50	noncommercial	noncommercial	ADJ
bam-5830	308	51	use	use	NOUN
bam-5830	308	52	,	,	PUNCT
bam-5830	308	53	distribution	distribution	NOUN
bam-5830	308	54	,	,	PUNCT
bam-5830	308	55	and	and	CCONJ
bam-5830	308	56	reproduction	reproduction	NOUN
bam-5830	308	57	in	in	ADP
bam-5830	308	58	any	any	DET
bam-5830	308	59	medium	medium	NOUN
bam-5830	308	60	,	,	PUNCT
bam-5830	308	61	provided	provide	VERB
bam-5830	308	62	the	the	DET
bam-5830	308	63	original	original	ADJ
bam-5830	308	64	author(s	author(s	NOUN
bam-5830	308	65	)	)	PUNCT
bam-5830	308	66	and	and	CCONJ
bam-5830	308	67	source	source	NOUN
bam-5830	308	68	are	be	AUX
bam-5830	308	69	credited	credit	VERB
bam-5830	308	70	.	.	PUNCT
bam-5830	309	1	11	11	NUM
bam-5830	309	2	in	in	ADP
bam-5830	309	3	this	this	DET
bam-5830	309	4	regard	regard	NOUN
bam-5830	309	5	,	,	PUNCT
bam-5830	309	6	impaired	impaired	ADJ
bam-5830	309	7	mitochondrial	mitochondrial	ADJ
bam-5830	309	8	functions	function	NOUN
bam-5830	309	9	and	and	CCONJ
bam-5830	309	10	altered	alter	VERB
bam-5830	309	11	energy	energy	NOUN
bam-5830	309	12	expenditure	expenditure	NOUN
bam-5830	309	13	likely	likely	ADV
bam-5830	309	14	play	play	VERB
bam-5830	309	15	a	a	DET
bam-5830	309	16	role	role	NOUN
bam-5830	309	17	.	.	PUNCT
bam-5830	310	1	recent	recent	ADJ
bam-5830	310	2	observations	observation	NOUN
bam-5830	310	3	suggest	suggest	VERB
bam-5830	310	4	that	that	SCONJ
bam-5830	310	5	in	in	ADP
bam-5830	310	6	addition	addition	NOUN
bam-5830	310	7	to	to	ADP
bam-5830	310	8	classical	classical	ADJ
bam-5830	310	9	humoral	humoral	ADJ
bam-5830	310	10	factors	factor	NOUN
bam-5830	310	11	such	such	ADJ
bam-5830	310	12	as	as	ADP
bam-5830	310	13	hormones	hormone	NOUN
bam-5830	310	14	or	or	CCONJ
bam-5830	310	15	cytokines	cytokine	NOUN
bam-5830	310	16	,	,	PUNCT
bam-5830	310	17	also	also	ADV
bam-5830	310	18	tumor	tumor	NOUN
bam-5830	310	19	-	-	PUNCT
bam-5830	310	20	derived	derive	VERB
bam-5830	310	21	microvesicles	microvesicle	NOUN
bam-5830	310	22	(	(	PUNCT
bam-5830	310	23	mvs	mvs	PROPN
bam-5830	310	24	)	)	PUNCT
bam-5830	310	25	,	,	PUNCT
bam-5830	310	26	circulating	circulate	VERB
bam-5830	310	27	particles	particle	NOUN
bam-5830	310	28	containing	contain	VERB
bam-5830	310	29	different	different	ADJ
bam-5830	310	30	molecules	molecule	NOUN
bam-5830	310	31	such	such	ADJ
bam-5830	310	32	as	as	ADP
bam-5830	310	33	proteins	protein	NOUN
bam-5830	310	34	,	,	PUNCT
bam-5830	310	35	mrnas	mrna	NOUN
bam-5830	310	36	and	and	CCONJ
bam-5830	310	37	micrornas	microrna	NOUN
bam-5830	310	38	,	,	PUNCT
bam-5830	310	39	may	may	AUX
bam-5830	310	40	contribute	contribute	VERB
bam-5830	310	41	to	to	ADP
bam-5830	310	42	derangements	derangement	NOUN
bam-5830	310	43	associated	associate	VERB
bam-5830	310	44	with	with	ADP
bam-5830	310	45	cachexia	cachexia	PROPN
bam-5830	310	46	(	(	PUNCT
bam-5830	310	47	1	1	NUM
bam-5830	310	48	)	)	PUNCT
bam-5830	310	49	.	.	PUNCT
bam-5830	311	1	mvs	mvs	PROPN
bam-5830	311	2	were	be	AUX
bam-5830	311	3	isolated	isolate	VERB
bam-5830	311	4	by	by	ADP
bam-5830	311	5	differential	differential	ADJ
bam-5830	311	6	ultracentrifugation	ultracentrifugation	NOUN
bam-5830	311	7	from	from	ADP
bam-5830	311	8	the	the	DET
bam-5830	311	9	conditioned	condition	VERB
bam-5830	311	10	medium	medium	NOUN
bam-5830	311	11	of	of	ADP
bam-5830	311	12	llc	llc	PROPN
bam-5830	311	13	(	(	PUNCT
bam-5830	311	14	lewis	lewis	PROPN
bam-5830	311	15	lung	lung	PROPN
bam-5830	311	16	carcinoma	carcinoma	NOUN
bam-5830	311	17	)	)	PUNCT
bam-5830	311	18	cells	cell	NOUN
bam-5830	311	19	and	and	CCONJ
bam-5830	311	20	were	be	AUX
bam-5830	311	21	quantified	quantify	VERB
bam-5830	311	22	by	by	ADP
bam-5830	311	23	a	a	DET
bam-5830	311	24	nanosight	nanosight	NOUN
bam-5830	311	25	apparatus	apparatus	NOUN
bam-5830	311	26	.	.	PUNCT
bam-5830	312	1	after	after	ADP
bam-5830	312	2	five	five	NUM
bam-5830	312	3	day	day	NOUN
bam-5830	312	4	culture	culture	NOUN
bam-5830	312	5	in	in	ADP
bam-5830	312	6	differentiation	differentiation	NOUN
bam-5830	312	7	medium	medium	NOUN
bam-5830	312	8	,	,	PUNCT
bam-5830	312	9	c2c12	c2c12	PROPN
bam-5830	312	10	myotubes	myotube	NOUN
bam-5830	312	11	were	be	AUX
bam-5830	312	12	treated	treat	VERB
bam-5830	312	13	for	for	ADP
bam-5830	312	14	24	24	NUM
bam-5830	312	15	h	h	NOUN
bam-5830	312	16	with	with	ADP
bam-5830	312	17	llc	llc	NOUN
bam-5830	312	18	-	-	PUNCT
bam-5830	312	19	derived	derive	VERB
bam-5830	312	20	mvs	mvs	NOUN
bam-5830	312	21	.	.	PUNCT
bam-5830	313	1	in	in	ADP
bam-5830	313	2	c2c12	c2c12	PROPN
bam-5830	313	3	myotubes	myotube	NOUN
bam-5830	313	4	tumor	tumor	NOUN
bam-5830	313	5	-	-	PUNCT
bam-5830	313	6	derived	derive	VERB
bam-5830	313	7	mvs	mvs	NOUN
bam-5830	313	8	induce	induce	VERB
bam-5830	313	9	a	a	DET
bam-5830	313	10	reduction	reduction	NOUN
bam-5830	313	11	of	of	ADP
bam-5830	313	12	pgc-1α	pgc-1α	NOUN
bam-5830	313	13	,	,	PUNCT
bam-5830	313	14	the	the	DET
bam-5830	313	15	master	master	NOUN
bam-5830	313	16	regulator	regulator	NOUN
bam-5830	313	17	of	of	ADP
bam-5830	313	18	oxidative	oxidative	ADJ
bam-5830	313	19	metabolisms	metabolism	NOUN
bam-5830	313	20	and	and	CCONJ
bam-5830	313	21	mitochondrial	mitochondrial	ADJ
bam-5830	313	22	biogenesis	biogenesis	NOUN
bam-5830	313	23	,	,	PUNCT
bam-5830	313	24	as	as	ADV
bam-5830	313	25	well	well	ADV
bam-5830	313	26	as	as	ADP
bam-5830	313	27	of	of	ADP
bam-5830	313	28	cyt	cyt	PROPN
bam-5830	313	29	-	-	PUNCT
bam-5830	313	30	c	c	PROPN
bam-5830	313	31	mrna	mrna	NOUN
bam-5830	313	32	expression	expression	NOUN
bam-5830	313	33	.	.	PUNCT
bam-5830	314	1	these	these	DET
bam-5830	314	2	results	result	NOUN
bam-5830	314	3	are	be	AUX
bam-5830	314	4	in	in	ADP
bam-5830	314	5	agreement	agreement	NOUN
bam-5830	314	6	with	with	ADP
bam-5830	314	7	previous	previous	ADJ
bam-5830	314	8	observations	observation	NOUN
bam-5830	314	9	showing	show	VERB
bam-5830	314	10	decreased	decrease	VERB
bam-5830	314	11	pgc1α	pgc1α	PROPN
bam-5830	314	12	expression	expression	NOUN
bam-5830	314	13	in	in	ADP
bam-5830	314	14	the	the	DET
bam-5830	314	15	skeletal	skeletal	ADJ
bam-5830	314	16	muscle	muscle	NOUN
bam-5830	314	17	of	of	ADP
bam-5830	314	18	cachectic	cachectic	ADJ
bam-5830	314	19	mice	mouse	NOUN
bam-5830	314	20	.	.	PUNCT
bam-5830	315	1	in	in	ADP
bam-5830	315	2	myotubes	myotube	NOUN
bam-5830	315	3	oxygen	oxygen	NOUN
bam-5830	315	4	consumption	consumption	NOUN
bam-5830	315	5	is	be	AUX
bam-5830	315	6	significantly	significantly	ADV
bam-5830	315	7	decreased	decrease	VERB
bam-5830	315	8	while	while	SCONJ
bam-5830	315	9	lactate	lactate	NOUN
bam-5830	315	10	levels	level	NOUN
bam-5830	315	11	in	in	ADP
bam-5830	315	12	the	the	DET
bam-5830	315	13	culture	culture	NOUN
bam-5830	315	14	medium	medium	NOUN
bam-5830	315	15	are	be	AUX
bam-5830	315	16	increased	increase	VERB
bam-5830	315	17	after	after	ADP
bam-5830	315	18	treatment	treatment	NOUN
bam-5830	315	19	with	with	ADP
bam-5830	315	20	mvs	mvs	PROPN
bam-5830	315	21	.	.	PUNCT
bam-5830	316	1	bnip3	bnip3	PROPN
bam-5830	316	2	mrna	mrna	PROPN
bam-5830	316	3	expression	expression	NOUN
bam-5830	316	4	is	be	AUX
bam-5830	316	5	significantly	significantly	ADV
bam-5830	316	6	increased	increase	VERB
bam-5830	316	7	,	,	PUNCT
bam-5830	316	8	while	while	SCONJ
bam-5830	316	9	no	no	DET
bam-5830	316	10	differences	difference	NOUN
bam-5830	316	11	can	can	AUX
bam-5830	316	12	be	be	AUX
bam-5830	316	13	observed	observe	VERB
bam-5830	316	14	as	as	ADP
bam-5830	316	15	for	for	ADP
bam-5830	316	16	myotube	myotube	NOUN
bam-5830	316	17	size	size	NOUN
bam-5830	316	18	and	and	CCONJ
bam-5830	316	19	mrna	mrna	NOUN
bam-5830	316	20	expression	expression	NOUN
bam-5830	316	21	of	of	ADP
bam-5830	316	22	both	both	DET
bam-5830	316	23	atrogin1	atrogin1	NOUN
bam-5830	316	24	and	and	CCONJ
bam-5830	316	25	murf-1	murf-1	PROPN
bam-5830	316	26	,	,	PUNCT
bam-5830	316	27	two	two	NUM
bam-5830	316	28	musclespecific	musclespecific	ADJ
bam-5830	316	29	ubiquitin	ubiquitin	NOUN
bam-5830	316	30	ligases	ligase	NOUN
bam-5830	316	31	.	.	PUNCT
bam-5830	317	1	these	these	DET
bam-5830	317	2	results	result	NOUN
bam-5830	317	3	suggest	suggest	VERB
bam-5830	317	4	that	that	SCONJ
bam-5830	317	5	tumorderived	tumorderive	VERB
bam-5830	317	6	mvs	mvs	PROPN
bam-5830	317	7	affect	affect	VERB
bam-5830	317	8	mitochondria	mitochondria	NOUN
bam-5830	317	9	in	in	ADP
bam-5830	317	10	c2c12	c2c12	PROPN
bam-5830	317	11	cultures	culture	NOUN
bam-5830	317	12	.	.	PUNCT
bam-5830	318	1	the	the	DET
bam-5830	318	2	reduction	reduction	NOUN
bam-5830	318	3	of	of	ADP
bam-5830	318	4	mitochondrial	mitochondrial	ADJ
bam-5830	318	5	mass	mass	NOUN
bam-5830	318	6	(	(	PUNCT
bam-5830	318	7	decreased	decrease	VERB
bam-5830	318	8	cyt	cyt	PROPN
bam-5830	318	9	-	-	PUNCT
bam-5830	318	10	c	c	PROPN
bam-5830	318	11	mrna	mrna	NOUN
bam-5830	318	12	expression	expression	NOUN
bam-5830	318	13	)	)	PUNCT
bam-5830	318	14	and	and	CCONJ
bam-5830	318	15	function	function	NOUN
bam-5830	318	16	is	be	AUX
bam-5830	318	17	associated	associate	VERB
bam-5830	318	18	with	with	ADP
bam-5830	318	19	down	down	NOUN
bam-5830	318	20	-	-	PUNCT
bam-5830	318	21	regulation	regulation	NOUN
bam-5830	318	22	of	of	ADP
bam-5830	318	23	pgc-1α	pgc-1α	NOUN
bam-5830	318	24	expression	expression	NOUN
bam-5830	318	25	and	and	CCONJ
bam-5830	318	26	enhancement	enhancement	NOUN
bam-5830	318	27	of	of	ADP
bam-5830	318	28	selective	selective	ADJ
bam-5830	318	29	autophagy	autophagy	NOUN
bam-5830	318	30	(	(	PUNCT
bam-5830	318	31	mitophagy	mitophagy	NOUN
bam-5830	318	32	)	)	PUNCT
bam-5830	318	33	.	.	PUNCT
bam-5830	319	1	on	on	ADP
bam-5830	319	2	the	the	DET
bam-5830	319	3	whole	whole	NOUN
bam-5830	319	4	,	,	PUNCT
bam-5830	319	5	mv	mv	ADJ
bam-5830	319	6	-	-	ADJ
bam-5830	319	7	induced	induced	ADJ
bam-5830	319	8	alterations	alteration	NOUN
bam-5830	319	9	could	could	AUX
bam-5830	319	10	contribute	contribute	VERB
bam-5830	319	11	to	to	ADP
bam-5830	319	12	muscle	muscle	NOUN
bam-5830	319	13	wasting	waste	VERB
bam-5830	319	14	during	during	ADP
bam-5830	319	15	cancer	cancer	NOUN
bam-5830	319	16	cachexia	cachexia	NOUN
bam-5830	319	17	.	.	PUNCT
bam-5830	320	1	1	1	X
bam-5830	320	2	.	.	X
bam-5830	320	3	he	he	PRON
bam-5830	320	4	wa	wa	VERB
bam-5830	320	5	,	,	PUNCT
bam-5830	320	6	calore	calore	PROPN
bam-5830	320	7	f	f	AUX
bam-5830	320	8	,	,	PUNCT
bam-5830	320	9	londhe	londhe	VERB
bam-5830	320	10	p	p	NOUN
bam-5830	320	11	,	,	PUNCT
bam-5830	320	12	canella	canella	PROPN
bam-5830	320	13	a	a	PRON
bam-5830	320	14	,	,	PUNCT
bam-5830	320	15	guttridge	guttridge	PROPN
bam-5830	320	16	dc	dc	PROPN
bam-5830	320	17	,	,	PUNCT
bam-5830	320	18	croce	croce	PROPN
bam-5830	320	19	cm	cm	PROPN
bam-5830	320	20	.	.	PUNCT
bam-5830	321	1	microvesicles	microvesicle	NOUN
bam-5830	321	2	containing	contain	VERB
bam-5830	321	3	mirnas	mirna	NOUN
bam-5830	321	4	promote	promote	VERB
bam-5830	321	5	muscle	muscle	NOUN
bam-5830	321	6	cell	cell	NOUN
bam-5830	321	7	death	death	NOUN
bam-5830	321	8	in	in	ADP
bam-5830	321	9	cancer	cancer	NOUN
bam-5830	321	10	cachexia	cachexia	NOUN
bam-5830	321	11	via	via	ADP
bam-5830	321	12	tlr7	tlr7	PROPN
bam-5830	321	13	.	.	PUNCT
bam-5830	322	1	proc	proc	PROPN
bam-5830	322	2	natl	natl	PROPN
bam-5830	322	3	acad	acad	PROPN
bam-5830	322	4	sci	sci	PROPN
bam-5830	322	5	u	u	PROPN
bam-5830	322	6	s	s	PROPN
bam-5830	322	7	a.	a.	NOUN
bam-5830	322	8	2014	2014	NUM
bam-5830	322	9	25;111(12):4525	25;111(12):4525	NUM
bam-5830	322	10	-	-	SYM
bam-5830	322	11	9	9	NUM
bam-5830	322	12	.	.	PUNCT
bam-5830	323	1	*	*	PUNCT
bam-5830	323	2	*	*	PUNCT
bam-5830	323	3	*	*	PUNCT
bam-5830	323	4	*	*	PUNCT
bam-5830	323	5	*	*	PUNCT
bam-5830	323	6	*	*	PUNCT
bam-5830	323	7	*	*	PUNCT
bam-5830	323	8	*	*	PUNCT
bam-5830	323	9	*	*	PUNCT
bam-5830	323	10	*	*	PUNCT
bam-5830	323	11	*	*	PUNCT
bam-5830	323	12	*	*	PUNCT
bam-5830	323	13	*	*	PUNCT
bam-5830	323	14	*	*	PUNCT
bam-5830	323	15	*	*	PUNCT
bam-5830	323	16	session	session	NOUN
bam-5830	323	17	4	4	NUM
bam-5830	323	18	metabolic	metabolic	NOUN
bam-5830	323	19	alterations	alteration	NOUN
bam-5830	323	20	and	and	CCONJ
bam-5830	323	21	muscle	muscle	NOUN
bam-5830	323	22	diseases	disease	NOUN
bam-5830	323	23	drp1	drp1	NOUN
bam-5830	323	24	overexpression	overexpression	NOUN
bam-5830	323	25	in	in	ADP
bam-5830	323	26	skeletal	skeletal	ADJ
bam-5830	323	27	muscle	muscle	NOUN
bam-5830	323	28	leads	lead	VERB
bam-5830	323	29	to	to	ADP
bam-5830	323	30	growth	growth	NOUN
bam-5830	323	31	defects	defect	NOUN
bam-5830	323	32	,	,	PUNCT
bam-5830	323	33	mitochondrial	mitochondrial	ADJ
bam-5830	323	34	stress	stress	NOUN
bam-5830	323	35	and	and	CCONJ
bam-5830	323	36	translational	translational	ADJ
bam-5830	323	37	impairment	impairment	NOUN
bam-5830	323	38	m.	m.	NOUN
bam-5830	323	39	giovarelli	giovarelli	PROPN
bam-5830	323	40	1	1	NUM
bam-5830	323	41	,	,	PUNCT
bam-5830	323	42	t.	t.	NOUN
bam-5830	323	43	touvier	touvier	NOUN
bam-5830	323	44	2	2	NUM
bam-5830	323	45	,	,	PUNCT
bam-5830	323	46	e.	e.	PROPN
bam-5830	323	47	clementi	clementi	PROPN
bam-5830	323	48	1,3	1,3	PROPN
bam-5830	323	49	,	,	PUNCT
bam-5830	323	50	c.	c.	PROPN
bam-5830	323	51	depalma1	depalma1	PROPN
bam-5830	323	52	1	1	NUM
bam-5830	323	53	.	.	X
bam-5830	324	1	department	department	NOUN
bam-5830	324	2	of	of	ADP
bam-5830	324	3	clinical	clinical	ADJ
bam-5830	324	4	and	and	CCONJ
bam-5830	324	5	biomedical	biomedical	ADJ
bam-5830	324	6	sciences	science	NOUN
bam-5830	324	7	,	,	PUNCT
bam-5830	324	8	unit	unit	NOUN
bam-5830	324	9	of	of	ADP
bam-5830	324	10	clinical	clinical	ADJ
bam-5830	324	11	pharmacology	pharmacology	NOUN
bam-5830	324	12	"	"	PUNCT
bam-5830	324	13	luigi	luigi	PROPN
bam-5830	324	14	sacco	sacco	PROPN
bam-5830	324	15	"	"	PUNCT
bam-5830	324	16	university	university	NOUN
bam-5830	324	17	hospital	hospital	NOUN
bam-5830	324	18	,	,	PUNCT
bam-5830	324	19	university	university	NOUN
bam-5830	324	20	of	of	ADP
bam-5830	324	21	milano	milano	PROPN
bam-5830	324	22	,	,	PUNCT
bam-5830	324	23	italy	italy	PROPN
bam-5830	324	24	;	;	PUNCT
bam-5830	324	25	2	2	X
bam-5830	324	26	.	.	X
bam-5830	324	27	consiglio	consiglio	PROPN
bam-5830	324	28	nazionale	nazionale	PROPN
bam-5830	324	29	delle	delle	PROPN
bam-5830	324	30	ricerche	ricerche	PROPN
bam-5830	324	31	institute	institute	PROPN
bam-5830	324	32	of	of	ADP
bam-5830	324	33	neuroscience	neuroscience	PROPN
bam-5830	324	34	,	,	PUNCT
bam-5830	324	35	italy	italy	PROPN
bam-5830	324	36	;	;	PUNCT
bam-5830	324	37	3	3	X
bam-5830	324	38	.	.	X
bam-5830	324	39	e.	e.	PROPN
bam-5830	324	40	medea	medea	PROPN
bam-5830	324	41	institute	institute	PROPN
bam-5830	324	42	,	,	PUNCT
bam-5830	324	43	bosisio	bosisio	PROPN
bam-5830	324	44	parini	parini	PROPN
bam-5830	324	45	,	,	PUNCT
bam-5830	324	46	lecco	lecco	PROPN
bam-5830	324	47	,	,	PUNCT
bam-5830	324	48	italy	italy	PROPN
bam-5830	324	49	e	e	NOUN
bam-5830	324	50	-	-	NOUN
bam-5830	324	51	mail	mail	NOUN
bam-5830	324	52	:	:	PUNCT
bam-5830	325	1	mgiovarelli@gmail.com	mgiovarelli@gmail.com	X
bam-5830	325	2	high	high	ADJ
bam-5830	325	3	mobility	mobility	NOUN
bam-5830	325	4	group	group	PROPN
bam-5830	325	5	box	box	PROPN
bam-5830	325	6	1	1	NUM
bam-5830	325	7	(	(	PUNCT
bam-5830	325	8	hmgb1	hmgb1	PROPN
bam-5830	325	9	)	)	PUNCT
bam-5830	325	10	is	be	AUX
bam-5830	325	11	a	a	DET
bam-5830	325	12	nuclear	nuclear	ADJ
bam-5830	325	13	protein	protein	NOUN
bam-5830	325	14	that	that	PRON
bam-5830	325	15	acts	act	VERB
bam-5830	325	16	extracellularly	extracellularly	ADV
bam-5830	325	17	as	as	ADP
bam-5830	325	18	an	an	DET
bam-5830	325	19	alarmin	alarmin	NOUN
bam-5830	325	20	to	to	PART
bam-5830	325	21	modulate	modulate	VERB
bam-5830	325	22	inflammation	inflammation	NOUN
bam-5830	325	23	and	and	CCONJ
bam-5830	325	24	tissue	tissue	NOUN
bam-5830	325	25	repair	repair	NOUN
bam-5830	325	26	by	by	ADP
bam-5830	325	27	recruiting	recruit	VERB
bam-5830	325	28	cells	cell	NOUN
bam-5830	325	29	and	and	CCONJ
bam-5830	325	30	promoting	promote	VERB
bam-5830	325	31	their	their	PRON
bam-5830	325	32	migration	migration	NOUN
bam-5830	325	33	and	and	CCONJ
bam-5830	325	34	activation	activation	NOUN
bam-5830	325	35	.	.	PUNCT
bam-5830	326	1	recently	recently	ADV
bam-5830	326	2	,	,	PUNCT
bam-5830	326	3	we	we	PRON
bam-5830	326	4	showed	show	VERB
bam-5830	326	5	that	that	SCONJ
bam-5830	326	6	hmgb1	hmgb1	PROPN
bam-5830	326	7	orchestrates	orchestrate	VERB
bam-5830	326	8	both	both	DET
bam-5830	326	9	processes	process	NOUN
bam-5830	326	10	by	by	ADP
bam-5830	326	11	switching	switch	VERB
bam-5830	326	12	among	among	ADP
bam-5830	326	13	mutually	mutually	ADV
bam-5830	326	14	exclusive	exclusive	ADJ
bam-5830	326	15	redox	redox	ADJ
bam-5830	326	16	states	state	NOUN
bam-5830	326	17	.	.	PUNCT
bam-5830	327	1	fully	fully	ADV
bam-5830	327	2	reduced	reduce	VERB
bam-5830	327	3	hmgb1	hmgb1	NOUN
bam-5830	327	4	acts	act	NOUN
bam-5830	327	5	as	as	ADP
bam-5830	327	6	a	a	DET
bam-5830	327	7	chemoattractant	chemoattractant	NOUN
bam-5830	327	8	,	,	PUNCT
bam-5830	327	9	whereas	whereas	SCONJ
bam-5830	327	10	a	a	DET
bam-5830	327	11	disulfide	disulfide	NOUN
bam-5830	327	12	bond	bond	NOUN
bam-5830	327	13	makes	make	VERB
bam-5830	327	14	it	it	PRON
bam-5830	327	15	a	a	DET
bam-5830	327	16	proinflammatory	proinflammatory	ADJ
bam-5830	327	17	cytokine	cytokine	NOUN
bam-5830	327	18	and	and	CCONJ
bam-5830	327	19	further	further	ADJ
bam-5830	327	20	cysteine	cysteine	NOUN
bam-5830	327	21	oxidation	oxidation	NOUN
bam-5830	327	22	by	by	ADP
bam-5830	327	23	reactive	reactive	ADJ
bam-5830	327	24	oxygen	oxygen	NOUN
bam-5830	327	25	species	specie	NOUN
bam-5830	327	26	(	(	PUNCT
bam-5830	327	27	ros	ros	PROPN
bam-5830	327	28	)	)	PUNCT
bam-5830	327	29	abrogates	abrogate	VERB
bam-5830	327	30	both	both	DET
bam-5830	327	31	activities	activity	NOUN
bam-5830	327	32	.	.	PUNCT
bam-5830	328	1	the	the	DET
bam-5830	328	2	fully	fully	ADV
bam-5830	328	3	reduced	reduce	VERB
bam-5830	328	4	hmgb1	hmgb1	PROPN
bam-5830	328	5	is	be	AUX
bam-5830	328	6	prevalent	prevalent	ADJ
bam-5830	328	7	in	in	ADP
bam-5830	328	8	the	the	DET
bam-5830	328	9	extracellular	extracellular	ADJ
bam-5830	328	10	environment	environment	NOUN
bam-5830	328	11	immediately	immediately	ADV
bam-5830	328	12	after	after	ADP
bam-5830	328	13	acute	acute	PROPN
bam-5830	328	14	muscle	muscle	NOUN
bam-5830	328	15	injury	injury	NOUN
bam-5830	328	16	,	,	PUNCT
bam-5830	328	17	and	and	CCONJ
bam-5830	328	18	disulfidehmgb1	disulfidehmgb1	PROPN
bam-5830	328	19	appears	appear	VERB
bam-5830	328	20	a	a	DET
bam-5830	328	21	few	few	ADJ
bam-5830	328	22	hours	hour	NOUN
bam-5830	328	23	later	later	ADV
bam-5830	328	24	.	.	PUNCT
bam-5830	329	1	thus	thus	ADV
bam-5830	329	2	,	,	PUNCT
bam-5830	329	3	the	the	DET
bam-5830	329	4	generation	generation	NOUN
bam-5830	329	5	of	of	ADP
bam-5830	329	6	ros	ros	PROPN
bam-5830	329	7	during	during	ADP
bam-5830	329	8	muscle	muscle	NOUN
bam-5830	329	9	damage	damage	NOUN
bam-5830	329	10	might	might	AUX
bam-5830	329	11	modulate	modulate	VERB
bam-5830	329	12	the	the	DET
bam-5830	329	13	redox	redox	ADJ
bam-5830	329	14	status	status	NOUN
bam-5830	329	15	of	of	ADP
bam-5830	329	16	the	the	DET
bam-5830	329	17	protein	protein	NOUN
bam-5830	329	18	and	and	CCONJ
bam-5830	329	19	eventually	eventually	ADV
bam-5830	329	20	limit	limit	VERB
bam-5830	329	21	its	its	PRON
bam-5830	329	22	lifespan	lifespan	NOUN
bam-5830	329	23	and	and	CCONJ
bam-5830	329	24	functions	function	NOUN
bam-5830	329	25	.	.	PUNCT
bam-5830	330	1	we	we	PRON
bam-5830	330	2	created	create	VERB
bam-5830	330	3	a	a	DET
bam-5830	330	4	mutant	mutant	NOUN
bam-5830	330	5	(	(	PUNCT
bam-5830	330	6	3s	3s	NOUN
bam-5830	330	7	-	-	PUNCT
bam-5830	330	8	hmgb1	hmgb1	NOUN
bam-5830	330	9	)	)	PUNCT
bam-5830	330	10	not	not	PART
bam-5830	330	11	susceptible	susceptible	ADJ
bam-5830	330	12	to	to	ADP
bam-5830	330	13	redox	redox	NOUN
bam-5830	330	14	modifications	modification	NOUN
bam-5830	330	15	and	and	CCONJ
bam-5830	330	16	we	we	PRON
bam-5830	330	17	evaluated	evaluate	VERB
bam-5830	330	18	its	its	PRON
bam-5830	330	19	regenerative	regenerative	ADJ
bam-5830	330	20	activity	activity	NOUN
bam-5830	330	21	in	in	ADP
bam-5830	330	22	a	a	DET
bam-5830	330	23	model	model	NOUN
bam-5830	330	24	of	of	ADP
bam-5830	330	25	acute	acute	ADJ
bam-5830	330	26	muscle	muscle	NOUN
bam-5830	330	27	injury	injury	NOUN
bam-5830	330	28	induced	induce	VERB
bam-5830	330	29	by	by	ADP
bam-5830	330	30	cardiotoxin	cardiotoxin	PROPN
bam-5830	330	31	.	.	PUNCT
bam-5830	331	1	we	we	PRON
bam-5830	331	2	demonstrated	demonstrate	VERB
bam-5830	331	3	so	so	ADV
bam-5830	331	4	far	far	ADV
bam-5830	331	5	that	that	SCONJ
bam-5830	331	6	hmgb1	hmgb1	PROPN
bam-5830	331	7	has	have	VERB
bam-5830	331	8	beneficial	beneficial	ADJ
bam-5830	331	9	effects	effect	NOUN
bam-5830	331	10	in	in	ADP
bam-5830	331	11	skeletal	skeletal	ADJ
bam-5830	331	12	muscle	muscle	NOUN
bam-5830	331	13	regeneration	regeneration	NOUN
bam-5830	331	14	after	after	ADP
bam-5830	331	15	acute	acute	ADJ
bam-5830	331	16	injury	injury	NOUN
bam-5830	331	17	by	by	ADP
bam-5830	331	18	dramatically	dramatically	ADV
bam-5830	331	19	increasing	increase	VERB
bam-5830	331	20	the	the	DET
bam-5830	331	21	number	number	NOUN
bam-5830	331	22	of	of	ADP
bam-5830	331	23	healthy	healthy	ADJ
bam-5830	331	24	fibers	fiber	NOUN
bam-5830	331	25	and	and	CCONJ
bam-5830	331	26	the	the	DET
bam-5830	331	27	number	number	NOUN
bam-5830	331	28	of	of	ADP
bam-5830	331	29	satellite	satellite	NOUN
bam-5830	331	30	cells	cell	NOUN
bam-5830	331	31	and	and	CCONJ
bam-5830	331	32	m2c	m2c	PUNCT
bam-5830	331	33	macrophages	macrophage	NOUN
bam-5830	331	34	,	,	PUNCT
bam-5830	331	35	two	two	NUM
bam-5830	331	36	cell	cell	NOUN
bam-5830	331	37	types	type	NOUN
bam-5830	331	38	essential	essential	ADJ
bam-5830	331	39	for	for	ADP
bam-5830	331	40	muscle	muscle	NOUN
bam-5830	331	41	repair	repair	NOUN
bam-5830	331	42	.	.	PUNCT
bam-5830	332	1	moreover	moreover	ADV
bam-5830	332	2	,	,	PUNCT
bam-5830	332	3	hmgb1	hmgb1	PROPN
bam-5830	332	4	acts	act	VERB
bam-5830	332	5	directly	directly	ADV
bam-5830	332	6	on	on	ADP
bam-5830	332	7	primary	primary	ADJ
bam-5830	332	8	myoblasts	myoblast	NOUN
bam-5830	332	9	by	by	ADP
bam-5830	332	10	inducing	induce	VERB
bam-5830	332	11	their	their	PRON
bam-5830	332	12	migration	migration	NOUN
bam-5830	332	13	and	and	CCONJ
bam-5830	332	14	their	their	PRON
bam-5830	332	15	fusion	fusion	NOUN
bam-5830	332	16	to	to	PART
bam-5830	332	17	form	form	VERB
bam-5830	332	18	large	large	ADJ
bam-5830	332	19	myotubes	myotube	NOUN
bam-5830	332	20	.	.	PUNCT
bam-5830	333	1	remarkably	remarkably	ADV
bam-5830	333	2	,	,	PUNCT
bam-5830	333	3	3s	3s	NUM
bam-5830	333	4	-	-	PUNCT
bam-5830	333	5	hmgb1	hmgb1	NOUN
bam-5830	333	6	behaves	behave	NOUN
bam-5830	333	7	as	as	ADP
bam-5830	333	8	a	a	DET
bam-5830	333	9	superagonist	superagonist	NOUN
bam-5830	333	10	of	of	ADP
bam-5830	333	11	hmgb1	hmgb1	PROPN
bam-5830	333	12	in	in	ADP
bam-5830	333	13	vivo	vivo	NOUN
bam-5830	333	14	,	,	PUNCT
bam-5830	333	15	suggesting	suggest	VERB
bam-5830	333	16	that	that	SCONJ
bam-5830	333	17	it	it	PRON
bam-5830	333	18	is	be	AUX
bam-5830	333	19	a	a	DET
bam-5830	333	20	promising	promising	ADJ
bam-5830	333	21	candidate	candidate	NOUN
bam-5830	333	22	for	for	ADP
bam-5830	333	23	muscle	muscle	NOUN
bam-5830	333	24	repair	repair	NOUN
bam-5830	333	25	therapies	therapy	NOUN
bam-5830	333	26	.	.	PUNCT
bam-5830	334	1	our	our	PRON
bam-5830	334	2	study	study	NOUN
bam-5830	334	3	will	will	AUX
bam-5830	334	4	be	be	AUX
bam-5830	334	5	extended	extend	VERB
bam-5830	334	6	to	to	ADP
bam-5830	334	7	other	other	ADJ
bam-5830	334	8	models	model	NOUN
bam-5830	334	9	of	of	ADP
bam-5830	334	10	muscle	muscle	NOUN
bam-5830	334	11	damage	damage	NOUN
bam-5830	334	12	,	,	PUNCT
bam-5830	334	13	in	in	ADP
bam-5830	334	14	particular	particular	ADJ
bam-5830	334	15	dystrophies	dystrophy	NOUN
bam-5830	334	16	,	,	PUNCT
bam-5830	334	17	in	in	ADP
bam-5830	334	18	order	order	NOUN
bam-5830	334	19	to	to	PART
bam-5830	334	20	evaluate	evaluate	VERB
bam-5830	334	21	the	the	DET
bam-5830	334	22	therapeutic	therapeutic	ADJ
bam-5830	334	23	potential	potential	NOUN
bam-5830	334	24	of	of	ADP
bam-5830	334	25	3s	3s	NOUN
bam-5830	334	26	-	-	PUNCT
bam-5830	334	27	hmgb1	hmgb1	NOUN
bam-5830	334	28	in	in	ADP
bam-5830	334	29	chronic	chronic	ADJ
bam-5830	334	30	conditions	condition	NOUN
bam-5830	334	31	.	.	PUNCT
bam-5830	335	1	*	*	PUNCT
bam-5830	336	1	*	*	PUNCT
bam-5830	336	2	*	*	PUNCT
bam-5830	336	3	*	*	PUNCT
bam-5830	336	4	*	*	NOUN
bam-5830	336	5	role	role	NOUN
bam-5830	336	6	of	of	ADP
bam-5830	336	7	the	the	DET
bam-5830	336	8	new	new	ADJ
bam-5830	336	9	e3	e3	NOUN
bam-5830	336	10	ubiquitin	ubiquitin	ADJ
bam-5830	336	11	ligase	ligase	PROPN
bam-5830	336	12	asb2	asb2	PROPN
bam-5830	336	13	in	in	ADP
bam-5830	336	14	skeletal	skeletal	ADJ
bam-5830	336	15	muscle	muscle	NOUN
bam-5830	336	16	f.	f.	PROPN
bam-5830	336	17	pescatore	pescatore	PROPN
bam-5830	336	18	1,2	1,2	NUM
bam-5830	336	19	,	,	PUNCT
bam-5830	336	20	m.	m.	NOUN
bam-5830	336	21	albiero	albiero	NOUN
bam-5830	336	22	1	1	NUM
bam-5830	336	23	,	,	PUNCT
bam-5830	336	24	c.	c.	PROPN
bam-5830	336	25	lutz	lutz	PROPN
bam-5830	336	26	3	3	NUM
bam-5830	336	27	,	,	PUNCT
bam-5830	336	28	s.	s.	PROPN
bam-5830	336	29	schiaffino	schiaffino	PROPN
bam-5830	336	30	1	1	NUM
bam-5830	336	31	,	,	PUNCT
bam-5830	336	32	m.	m.	NOUN
bam-5830	336	33	sandri1,2	sandri1,2	PROPN
bam-5830	336	34	1	1	NUM
bam-5830	336	35	.	.	PUNCT
bam-5830	336	36	venetian	venetian	ADJ
bam-5830	336	37	institute	institute	NOUN
bam-5830	336	38	of	of	ADP
bam-5830	336	39	molecular	molecular	ADJ
bam-5830	336	40	medicine	medicine	NOUN
bam-5830	336	41	(	(	PUNCT
bam-5830	336	42	vimm	vimm	PROPN
bam-5830	336	43	)	)	PUNCT
bam-5830	336	44	,	,	PUNCT
bam-5830	336	45	italy	italy	PROPN
bam-5830	336	46	;	;	PUNCT
bam-5830	336	47	2	2	X
bam-5830	336	48	.	.	X
bam-5830	336	49	department	department	NOUN
bam-5830	336	50	of	of	ADP
bam-5830	336	51	biomedical	biomedical	ADJ
bam-5830	336	52	sciences	sciences	PROPN
bam-5830	336	53	,	,	PUNCT
bam-5830	336	54	university	university	PROPN
bam-5830	336	55	of	of	ADP
bam-5830	336	56	padua	padua	PROPN
bam-5830	336	57	,	,	PUNCT
bam-5830	336	58	italy	italy	PROPN
bam-5830	336	59	;	;	PUNCT
bam-5830	336	60	3.ipbs	3.ipbs	NUM
bam-5830	336	61	institut	institut	PROPN
bam-5830	336	62	de	de	PROPN
bam-5830	336	63	pharmacologie	pharmacologie	PROPN
bam-5830	336	64	et	et	PROPN
bam-5830	336	65	de	de	PROPN
bam-5830	336	66	biologie	biologie	PROPN
bam-5830	336	67	structurale	structurale	PROPN
bam-5830	336	68	,	,	PUNCT
bam-5830	336	69	toulouse	toulouse	NOUN
bam-5830	336	70	,	,	PUNCT
bam-5830	336	71	france	france	PROPN
bam-5830	336	72	e	e	NOUN
bam-5830	336	73	-	-	NOUN
bam-5830	336	74	mail	mail	NOUN
bam-5830	336	75	:	:	PUNCT
bam-5830	336	76	francescapescatore@hotmail.it	francescapescatore@hotmail.it	ADJ
bam-5830	336	77	atrophy	atrophy	NOUN
bam-5830	336	78	is	be	AUX
bam-5830	336	79	an	an	DET
bam-5830	336	80	active	active	ADJ
bam-5830	336	81	process	process	NOUN
bam-5830	336	82	controlled	control	VERB
bam-5830	336	83	by	by	ADP
bam-5830	336	84	specific	specific	ADJ
bam-5830	336	85	signaling	signal	VERB
bam-5830	336	86	pathways	pathway	NOUN
bam-5830	336	87	and	and	CCONJ
bam-5830	336	88	transcriptional	transcriptional	ADJ
bam-5830	336	89	programs	program	NOUN
bam-5830	336	90	.	.	PUNCT
bam-5830	337	1	the	the	DET
bam-5830	337	2	identification	identification	NOUN
bam-5830	337	3	of	of	ADP
bam-5830	337	4	the	the	DET
bam-5830	337	5	precise	precise	ADJ
bam-5830	337	6	signaling	signal	VERB
bam-5830	337	7	cascades	cascade	NOUN
bam-5830	337	8	that	that	PRON
bam-5830	337	9	regulate	regulate	VERB
bam-5830	337	10	muscle	muscle	NOUN
bam-5830	337	11	wasting	waste	VERB
bam-5830	337	12	remains	remain	VERB
bam-5830	337	13	poorly	poorly	ADV
bam-5830	337	14	understood	understand	VERB
bam-5830	337	15	.	.	PUNCT
bam-5830	338	1	the	the	DET
bam-5830	338	2	ubiquitin	ubiquitin	ADJ
bam-5830	338	3	proteasome	proteasome	NOUN
bam-5830	338	4	system	system	NOUN
bam-5830	338	5	(	(	PUNCT
bam-5830	338	6	ups	up	NOUN
bam-5830	338	7	)	)	PUNCT
bam-5830	338	8	is	be	AUX
bam-5830	338	9	one	one	NUM
bam-5830	338	10	of	of	ADP
bam-5830	338	11	the	the	DET
bam-5830	338	12	major	major	ADJ
bam-5830	338	13	systems	system	NOUN
bam-5830	338	14	that	that	PRON
bam-5830	338	15	control	control	VERB
bam-5830	338	16	protein	protein	NOUN
bam-5830	338	17	breakdown	breakdown	NOUN
bam-5830	338	18	during	during	ADP
bam-5830	338	19	muscle	muscle	NOUN
bam-5830	338	20	wasting	waste	VERB
bam-5830	338	21	.	.	PUNCT
bam-5830	339	1	the	the	DET
bam-5830	339	2	specificity	specificity	NOUN
bam-5830	339	3	of	of	ADP
bam-5830	339	4	ubiquitin	ubiquitin	ADJ
bam-5830	339	5	-	-	PUNCT
bam-5830	339	6	dependent	dependent	ADJ
bam-5830	339	7	degradation	degradation	NOUN
bam-5830	339	8	derives	derive	VERB
bam-5830	339	9	from	from	ADP
bam-5830	339	10	many	many	ADJ
bam-5830	339	11	e3s	e3s	PROPN
bam-5830	339	12	that	that	PRON
bam-5830	339	13	recognize	recognize	VERB
bam-5830	339	14	specific	specific	ADJ
bam-5830	339	15	substrates	substrate	NOUN
bam-5830	339	16	.	.	PUNCT
bam-5830	340	1	this	this	DET
bam-5830	340	2	work	work	NOUN
bam-5830	340	3	is	be	AUX
bam-5830	340	4	focus	focus	NOUN
bam-5830	340	5	on	on	ADP
bam-5830	340	6	a	a	DET
bam-5830	340	7	novel	novel	ADJ
bam-5830	340	8	muscle	muscle	NOUN
bam-5830	340	9	-	-	PUNCT
bam-5830	340	10	specific	specific	ADJ
bam-5830	340	11	circadian	circadian	ADJ
bam-5830	340	12	-	-	PUNCT
bam-5830	340	13	rhythm	rhythm	NOUN
bam-5830	340	14	dependent	dependent	ADJ
bam-5830	340	15	ubiquitin	ubiquitin	NOUN
bam-5830	340	16	ligase	ligase	NOUN
bam-5830	340	17	named	name	VERB
bam-5830	340	18	asb2.	asb2.	NOUN
bam-5830	340	19	to	to	PART
bam-5830	340	20	dissect	dissect	VERB
bam-5830	340	21	its	its	PRON
bam-5830	340	22	role	role	NOUN
bam-5830	340	23	,	,	PUNCT
bam-5830	340	24	we	we	PRON
bam-5830	340	25	have	have	AUX
bam-5830	340	26	generated	generate	VERB
bam-5830	340	27	muscle	muscle	NOUN
bam-5830	340	28	specific	specific	ADJ
bam-5830	340	29	and	and	CCONJ
bam-5830	340	30	tamoxifen	tamoxifen	NOUN
bam-5830	340	31	-	-	PUNCT
bam-5830	340	32	inducible	inducible	ADJ
bam-5830	340	33	muscle	muscle	NOUN
bam-5830	340	34	specific	specific	ADJ
bam-5830	340	35	knock	knock	NOUN
bam-5830	340	36	-	-	PUNCT
bam-5830	340	37	out	out	ADP
bam-5830	340	38	mice	mouse	NOUN
bam-5830	340	39	.	.	PUNCT
bam-5830	341	1	we	we	PRON
bam-5830	341	2	have	have	AUX
bam-5830	341	3	characterized	characterize	VERB
bam-5830	341	4	these	these	DET
bam-5830	341	5	knockout	knockout	NOUN
bam-5830	341	6	mice	mouse	NOUN
bam-5830	341	7	in	in	ADP
bam-5830	341	8	physiological	physiological	ADJ
bam-5830	341	9	and	and	CCONJ
bam-5830	341	10	in	in	ADP
bam-5830	341	11	catabolic	catabolic	ADJ
bam-5830	341	12	conditions	condition	NOUN
bam-5830	341	13	.	.	PUNCT
bam-5830	342	1	asb2	asb2	PROPN
bam-5830	342	2	defective	defective	ADJ
bam-5830	342	3	muscles	muscle	NOUN
bam-5830	342	4	show	show	VERB
bam-5830	342	5	normal	normal	ADJ
bam-5830	342	6	muscle	muscle	NOUN
bam-5830	342	7	morphology	morphology	NOUN
bam-5830	342	8	and	and	CCONJ
bam-5830	342	9	mitochondrial	mitochondrial	ADJ
bam-5830	342	10	content	content	NOUN
bam-5830	342	11	but	but	CCONJ
bam-5830	342	12	muscles	muscle	NOUN
bam-5830	342	13	display	display	VERB
bam-5830	342	14	a	a	DET
bam-5830	342	15	fiber	fiber	NOUN
bam-5830	342	16	type	type	NOUN
bam-5830	342	17	switch	switch	NOUN
bam-5830	342	18	and	and	CCONJ
bam-5830	342	19	glycogen	glycogen	NOUN
bam-5830	342	20	accumulation	accumulation	NOUN
bam-5830	342	21	.	.	PUNCT
bam-5830	343	1	glucose	glucose	NOUN
bam-5830	343	2	tolerance	tolerance	NOUN
bam-5830	343	3	test	test	NOUN
bam-5830	343	4	revealed	reveal	VERB
bam-5830	343	5	an	an	DET
bam-5830	343	6	improved	improved	ADJ
bam-5830	343	7	glucose	glucose	NOUN
bam-5830	343	8	uptake	uptake	NOUN
bam-5830	343	9	in	in	ADP
bam-5830	343	10	knockout	knockout	NOUN
bam-5830	343	11	mice	mouse	NOUN
bam-5830	343	12	.	.	PUNCT
bam-5830	344	1	moreover	moreover	ADV
bam-5830	344	2	,	,	PUNCT
bam-5830	344	3	glycogen	glycogen	NOUN
bam-5830	344	4	content	content	NOUN
bam-5830	344	5	dramatically	dramatically	ADV
bam-5830	344	6	decreased	decrease	VERB
bam-5830	344	7	in	in	ADP
bam-5830	344	8	asb2	asb2	PROPN
bam-5830	344	9	knockout	knockout	NOUN
bam-5830	344	10	mice	mouse	NOUN
bam-5830	344	11	during	during	ADP
bam-5830	344	12	fasting	fast	VERB
bam-5830	344	13	.	.	PUNCT
bam-5830	345	1	the	the	DET
bam-5830	345	2	changes	change	NOUN
bam-5830	345	3	in	in	ADP
bam-5830	345	4	glucose	glucose	NOUN
bam-5830	345	5	homeostasis	homeostasis	NOUN
bam-5830	345	6	are	be	AUX
bam-5830	345	7	akt	akt	NOUN
bam-5830	345	8	independent	independent	ADJ
bam-5830	345	9	but	but	CCONJ
bam-5830	345	10	tbc1d1and	tbc1d1and	PROPN
bam-5830	345	11	as160	as160	PROPN
bam-5830	345	12	dependent	dependent	ADJ
bam-5830	345	13	.	.	PUNCT
bam-5830	346	1	however	however	ADV
bam-5830	346	2	,	,	PUNCT
bam-5830	346	3	absence	absence	NOUN
bam-5830	346	4	of	of	ADP
bam-5830	346	5	nutrients	nutrient	NOUN
bam-5830	346	6	triggers	trigger	VERB
bam-5830	346	7	necrotic	necrotic	ADJ
bam-5830	346	8	degeneration	degeneration	NOUN
bam-5830	346	9	and	and	CCONJ
bam-5830	346	10	appearance	appearance	NOUN
bam-5830	346	11	of	of	ADP
bam-5830	346	12	abnormal	abnormal	ADJ
bam-5830	346	13	mitochondria	mitochondria	NOUN
bam-5830	346	14	in	in	ADP
bam-5830	346	15	asb2-null	asb2-null	NOUN
bam-5830	346	16	muscles	muscle	NOUN
bam-5830	346	17	.	.	PUNCT
bam-5830	347	1	we	we	PRON
bam-5830	347	2	have	have	AUX
bam-5830	347	3	also	also	ADV
bam-5830	347	4	started	start	VERB
bam-5830	347	5	to	to	PART
bam-5830	347	6	characterize	characterize	VERB
bam-5830	347	7	the	the	DET
bam-5830	347	8	tamoxifeninducible	tamoxifeninducible	ADJ
bam-5830	347	9	knockout	knockout	NOUN
bam-5830	347	10	mice	mouse	NOUN
bam-5830	347	11	.	.	PUNCT
bam-5830	348	1	preliminary	preliminary	ADJ
bam-5830	348	2	data	datum	NOUN
bam-5830	348	3	show	show	VERB
bam-5830	348	4	that	that	SCONJ
bam-5830	348	5	acute	acute	NOUN
bam-5830	348	6	inhibition	inhibition	NOUN
bam-5830	348	7	of	of	ADP
bam-5830	348	8	asb2	asb2	PROPN
bam-5830	348	9	induces	induce	VERB
bam-5830	348	10	a	a	DET
bam-5830	348	11	time	time	NOUN
bam-5830	348	12	dependent	dependent	ADJ
bam-5830	348	13	muscle	muscle	NOUN
bam-5830	348	14	growth	growth	NOUN
bam-5830	348	15	.	.	PUNCT
bam-5830	349	1	in	in	ADP
bam-5830	349	2	conclusion	conclusion	NOUN
bam-5830	349	3	,	,	PUNCT
bam-5830	349	4	we	we	PRON
bam-5830	349	5	have	have	AUX
bam-5830	349	6	identified	identify	VERB
bam-5830	349	7	a	a	DET
bam-5830	349	8	novel	novel	ADJ
bam-5830	349	9	muscle	muscle	NOUN
bam-5830	349	10	specific	specific	ADJ
bam-5830	349	11	ubiquitin	ubiquitin	NOUN
bam-5830	349	12	ligase	ligase	NOUN
bam-5830	349	13	,	,	PUNCT
bam-5830	349	14	asb2	asb2	PROPN
bam-5830	349	15	,	,	PUNCT
bam-5830	349	16	that	that	PRON
bam-5830	349	17	plays	play	VERB
bam-5830	349	18	an	an	DET
bam-5830	349	19	important	important	ADJ
bam-5830	349	20	role	role	NOUN
bam-5830	349	21	in	in	ADP
bam-5830	349	22	glucose	glucose	NOUN
bam-5830	349	23	homeostasis	homeostasis	NOUN
bam-5830	349	24	and	and	CCONJ
bam-5830	349	25	muscle	muscle	NOUN
bam-5830	349	26	hypertrophy	hypertrophy	NOUN
bam-5830	349	27	.	.	PUNCT
bam-5830	350	1	*	*	PUNCT
bam-5830	350	2	*	*	PUNCT
bam-5830	350	3	*	*	PUNCT
bam-5830	350	4	*	*	PUNCT
bam-5830	350	5	*	*	VERB
bam-5830	350	6	abstracts	abstract	NOUN
bam-5830	350	7	of	of	ADP
bam-5830	350	8	the	the	DET
bam-5830	350	9	xii	xii	PROPN
bam-5830	350	10	iim	iim	NOUN
bam-5830	350	11	myology	myology	NOUN
bam-5830	350	12	meeting	meeting	NOUN
bam-5830	350	13	october	october	PROPN
bam-5830	350	14	1–4	1–4	PROPN
bam-5830	350	15	,	,	PUNCT
bam-5830	350	16	2015	2015	NUM
bam-5830	350	17	eur	eur	PROPN
bam-5830	350	18	j	j	PROPN
bam-5830	350	19	transl	transl	PROPN
bam-5830	350	20	myol	myol	PROPN
bam-5830	350	21	basic	basic	ADJ
bam-5830	350	22	appl	appl	NOUN
bam-5830	350	23	myol	myol	NOUN
bam-5830	350	24	2016	2016	NUM
bam-5830	350	25	;	;	PUNCT
bam-5830	350	26	26	26	NUM
bam-5830	350	27	(	(	PUNCT
bam-5830	350	28	1):2	1):2	NUM
bam-5830	350	29	-	-	SYM
bam-5830	350	30	24	24	NUM
bam-5830	350	31	this	this	DET
bam-5830	350	32	article	article	NOUN
bam-5830	350	33	is	be	AUX
bam-5830	350	34	distributed	distribute	VERB
bam-5830	350	35	under	under	ADP
bam-5830	350	36	the	the	DET
bam-5830	350	37	terms	term	NOUN
bam-5830	350	38	of	of	ADP
bam-5830	350	39	the	the	DET
bam-5830	350	40	creative	creative	ADJ
bam-5830	350	41	commons	common	NOUN
bam-5830	350	42	attribution	attribution	NOUN
bam-5830	350	43	noncommercial	noncommercial	ADJ
bam-5830	350	44	license	license	NOUN
bam-5830	350	45	(	(	PUNCT
bam-5830	350	46	cc	cc	NOUN
bam-5830	350	47	by	by	ADP
bam-5830	350	48	-	-	PUNCT
bam-5830	350	49	nc	nc	PROPN
bam-5830	350	50	4.0	4.0	NUM
bam-5830	350	51	)	)	PUNCT
bam-5830	350	52	which	which	PRON
bam-5830	350	53	permits	permit	VERB
bam-5830	350	54	any	any	DET
bam-5830	350	55	noncommercial	noncommercial	ADJ
bam-5830	350	56	use	use	NOUN
bam-5830	350	57	,	,	PUNCT
bam-5830	350	58	distribution	distribution	NOUN
bam-5830	350	59	,	,	PUNCT
bam-5830	350	60	and	and	CCONJ
bam-5830	350	61	reproduction	reproduction	NOUN
bam-5830	350	62	in	in	ADP
bam-5830	350	63	any	any	DET
bam-5830	350	64	medium	medium	NOUN
bam-5830	350	65	,	,	PUNCT
bam-5830	350	66	provided	provide	VERB
bam-5830	350	67	the	the	DET
bam-5830	350	68	original	original	ADJ
bam-5830	350	69	author(s	author(s	NOUN
bam-5830	350	70	)	)	PUNCT
bam-5830	350	71	and	and	CCONJ
bam-5830	350	72	source	source	NOUN
bam-5830	350	73	are	be	AUX
bam-5830	350	74	credited	credit	VERB
bam-5830	350	75	.	.	PUNCT
bam-5830	351	1	12	12	NUM
bam-5830	351	2	perilipin	perilipin	NOUN
bam-5830	351	3	2	2	NUM
bam-5830	351	4	downregulation	downregulation	NOUN
bam-5830	351	5	induces	induce	VERB
bam-5830	351	6	skeletal	skeletal	ADJ
bam-5830	351	7	muscle	muscle	NOUN
bam-5830	351	8	hypertrophy	hypertrophy	NOUN
bam-5830	351	9	m.	m.	NOUN
bam-5830	351	10	conte	conte	PROPN
bam-5830	351	11	1	1	NUM
bam-5830	351	12	,	,	PUNCT
bam-5830	351	13	a.	a.	NOUN
bam-5830	351	14	armani	armani	PROPN
bam-5830	351	15	2	2	NUM
bam-5830	351	16	,	,	PUNCT
bam-5830	351	17	m.	m.	NOUN
bam-5830	351	18	sandri	sandri	NOUN
bam-5830	351	19	2	2	NUM
bam-5830	351	20	,	,	PUNCT
bam-5830	351	21	c.	c.	PROPN
bam-5830	351	22	franceschi	franceschi	PROPN
bam-5830	351	23	1	1	NUM
bam-5830	351	24	,	,	PUNCT
bam-5830	351	25	s.	s.	PROPN
bam-5830	351	26	salvioli	salvioli	PROPN
bam-5830	351	27	1	1	NUM
bam-5830	351	28	1	1	NUM
bam-5830	351	29	.	.	PUNCT
bam-5830	352	1	department	department	NOUN
bam-5830	352	2	of	of	ADP
bam-5830	352	3	experimental	experimental	ADJ
bam-5830	352	4	,	,	PUNCT
bam-5830	352	5	diagnostic	diagnostic	ADJ
bam-5830	352	6	and	and	CCONJ
bam-5830	352	7	specialty	specialty	NOUN
bam-5830	352	8	medicine	medicine	NOUN
bam-5830	352	9	and	and	CCONJ
bam-5830	352	10	interdepartmental	interdepartmental	ADJ
bam-5830	352	11	centre	centre	NOUN
bam-5830	352	12	“	"	PUNCT
bam-5830	352	13	l.	l.	PROPN
bam-5830	352	14	galvani	galvani	PROPN
bam-5830	352	15	”	"	PUNCT
bam-5830	352	16	(	(	PUNCT
bam-5830	352	17	cig	cig	PROPN
bam-5830	352	18	)	)	PUNCT
bam-5830	352	19	,	,	PUNCT
bam-5830	352	20	university	university	NOUN
bam-5830	352	21	of	of	ADP
bam-5830	352	22	bologna	bologna	NOUN
bam-5830	352	23	;	;	PUNCT
bam-5830	352	24	2	2	X
bam-5830	352	25	.	.	X
bam-5830	352	26	dulbecco	dulbecco	PROPN
bam-5830	352	27	telethon	telethon	PROPN
bam-5830	352	28	institute	institute	NOUN
bam-5830	352	29	,	,	PUNCT
bam-5830	352	30	venetian	venetian	PROPN
bam-5830	352	31	institute	institute	NOUN
bam-5830	352	32	of	of	ADP
bam-5830	352	33	molecular	molecular	ADJ
bam-5830	352	34	medicine	medicine	NOUN
bam-5830	352	35	,	,	PUNCT
bam-5830	352	36	padova	padova	PROPN
bam-5830	352	37	,	,	PUNCT
bam-5830	352	38	italy	italy	PROPN
bam-5830	352	39	e	e	PROPN
bam-5830	352	40	-	-	NOUN
bam-5830	352	41	mail	mail	NOUN
bam-5830	352	42	m.conte@unibo.it	m.conte@unibo.it	NOUN
bam-5830	352	43	aging	age	VERB
bam-5830	352	44	is	be	AUX
bam-5830	352	45	characterized	characterize	VERB
bam-5830	352	46	by	by	ADP
bam-5830	352	47	loss	loss	NOUN
bam-5830	352	48	of	of	ADP
bam-5830	352	49	skeletal	skeletal	ADJ
bam-5830	352	50	muscle	muscle	NOUN
bam-5830	352	51	mass	mass	NOUN
bam-5830	352	52	and	and	CCONJ
bam-5830	352	53	function	function	NOUN
bam-5830	352	54	,	,	PUNCT
bam-5830	352	55	condition	condition	NOUN
bam-5830	352	56	known	know	VERB
bam-5830	352	57	as	as	ADP
bam-5830	352	58	sarcopenia	sarcopenia	NOUN
bam-5830	352	59	.	.	PUNCT
bam-5830	353	1	the	the	DET
bam-5830	353	2	mechanisms	mechanism	NOUN
bam-5830	353	3	underlying	underlie	VERB
bam-5830	353	4	sarcopenia	sarcopenia	NOUN
bam-5830	353	5	are	be	AUX
bam-5830	353	6	not	not	PART
bam-5830	353	7	completely	completely	ADV
bam-5830	353	8	understood	understand	VERB
bam-5830	353	9	,	,	PUNCT
bam-5830	353	10	however	however	ADV
bam-5830	353	11	a	a	DET
bam-5830	353	12	role	role	NOUN
bam-5830	353	13	for	for	ADP
bam-5830	353	14	ectopic	ectopic	ADJ
bam-5830	353	15	fat	fat	ADJ
bam-5830	353	16	accumulation	accumulation	NOUN
bam-5830	353	17	has	have	AUX
bam-5830	353	18	been	be	AUX
bam-5830	353	19	proposed	propose	VERB
bam-5830	353	20	.	.	PUNCT
bam-5830	354	1	skeletal	skeletal	ADJ
bam-5830	354	2	muscle	muscle	NOUN
bam-5830	354	3	accumulates	accumulate	VERB
bam-5830	354	4	lipid	lipid	NOUN
bam-5830	354	5	in	in	ADP
bam-5830	354	6	form	form	NOUN
bam-5830	354	7	of	of	ADP
bam-5830	354	8	triglycerides	triglyceride	NOUN
bam-5830	354	9	within	within	ADP
bam-5830	354	10	lipid	lipid	NOUN
bam-5830	354	11	droplets	droplet	NOUN
bam-5830	354	12	(	(	PUNCT
bam-5830	354	13	lds	ld	NOUN
bam-5830	354	14	)	)	PUNCT
bam-5830	354	15	.	.	PUNCT
bam-5830	355	1	lds	ld	NOUN
bam-5830	355	2	are	be	AUX
bam-5830	355	3	characterized	characterize	VERB
bam-5830	355	4	by	by	ADP
bam-5830	355	5	the	the	DET
bam-5830	355	6	presence	presence	NOUN
bam-5830	355	7	of	of	ADP
bam-5830	355	8	perilipins	perilipin	NOUN
bam-5830	355	9	(	(	PUNCT
bam-5830	355	10	plins	plin	NOUN
bam-5830	355	11	)	)	PUNCT
bam-5830	355	12	,	,	PUNCT
bam-5830	355	13	that	that	SCONJ
bam-5830	355	14	control	control	NOUN
bam-5830	355	15	lipid	lipid	NOUN
bam-5830	355	16	accumulation	accumulation	NOUN
bam-5830	355	17	and	and	CCONJ
bam-5830	355	18	metabolism	metabolism	NOUN
bam-5830	355	19	under	under	ADP
bam-5830	355	20	physiological	physiological	ADJ
bam-5830	355	21	and	and	CCONJ
bam-5830	355	22	pathological	pathological	ADJ
bam-5830	355	23	conditions	condition	NOUN
bam-5830	355	24	.	.	PUNCT
bam-5830	356	1	in	in	ADP
bam-5830	356	2	skeletal	skeletal	ADJ
bam-5830	356	3	muscle	muscle	NOUN
bam-5830	356	4	one	one	NUM
bam-5830	356	5	of	of	ADP
bam-5830	356	6	the	the	DET
bam-5830	356	7	most	most	ADV
bam-5830	356	8	representative	representative	NOUN
bam-5830	356	9	is	be	AUX
bam-5830	356	10	plin2	plin2	NOUN
bam-5830	356	11	,	,	PUNCT
bam-5830	356	12	particularly	particularly	ADV
bam-5830	356	13	involved	involve	VERB
bam-5830	356	14	in	in	ADP
bam-5830	356	15	lipid	lipid	NOUN
bam-5830	356	16	storage	storage	NOUN
bam-5830	356	17	.	.	PUNCT
bam-5830	357	1	however	however	ADV
bam-5830	357	2	,	,	PUNCT
bam-5830	357	3	the	the	DET
bam-5830	357	4	exact	exact	ADJ
bam-5830	357	5	role	role	NOUN
bam-5830	357	6	of	of	ADP
bam-5830	357	7	plin2	plin2	NOUN
bam-5830	357	8	is	be	AUX
bam-5830	357	9	not	not	PART
bam-5830	357	10	still	still	ADV
bam-5830	357	11	clear	clear	ADJ
bam-5830	357	12	.	.	PUNCT
bam-5830	358	1	we	we	PRON
bam-5830	358	2	found	find	VERB
bam-5830	358	3	that	that	SCONJ
bam-5830	358	4	in	in	ADP
bam-5830	358	5	human	human	ADJ
bam-5830	358	6	muscle	muscle	NOUN
bam-5830	358	7	the	the	DET
bam-5830	358	8	expression	expression	NOUN
bam-5830	358	9	of	of	ADP
bam-5830	358	10	plin2	plin2	NOUN
bam-5830	358	11	increases	increase	VERB
bam-5830	358	12	with	with	ADP
bam-5830	358	13	aging	aging	NOUN
bam-5830	358	14	and	and	CCONJ
bam-5830	358	15	it	it	PRON
bam-5830	358	16	is	be	AUX
bam-5830	358	17	inversely	inversely	ADV
bam-5830	358	18	associated	associate	VERB
bam-5830	358	19	with	with	ADP
bam-5830	358	20	muscle	muscle	NOUN
bam-5830	358	21	mass	mass	NOUN
bam-5830	358	22	and	and	CCONJ
bam-5830	358	23	strength	strength	NOUN
bam-5830	358	24	.	.	PUNCT
bam-5830	359	1	moreover	moreover	ADV
bam-5830	359	2	,	,	PUNCT
bam-5830	359	3	plin2	plin2	NOUN
bam-5830	359	4	expression	expression	NOUN
bam-5830	359	5	is	be	AUX
bam-5830	359	6	associated	associate	VERB
bam-5830	359	7	with	with	ADP
bam-5830	359	8	atrophy	atrophy	NOUN
bam-5830	359	9	-	-	PUNCT
bam-5830	359	10	related	relate	VERB
bam-5830	359	11	genes	gene	NOUN
bam-5830	359	12	,	,	PUNCT
bam-5830	359	13	murf-1	murf-1	PROPN
bam-5830	359	14	and	and	CCONJ
bam-5830	359	15	atrogin	atrogin	NOUN
bam-5830	359	16	,	,	PUNCT
bam-5830	359	17	suggesting	suggest	VERB
bam-5830	359	18	a	a	DET
bam-5830	359	19	role	role	NOUN
bam-5830	359	20	for	for	ADP
bam-5830	359	21	plin2	plin2	NOUN
bam-5830	359	22	in	in	ADP
bam-5830	359	23	muscle	muscle	NOUN
bam-5830	359	24	aging	aging	NOUN
bam-5830	359	25	and	and	CCONJ
bam-5830	359	26	atrophy	atrophy	NOUN
bam-5830	359	27	.	.	PUNCT
bam-5830	360	1	we	we	PRON
bam-5830	360	2	also	also	ADV
bam-5830	360	3	analysed	analyse	VERB
bam-5830	360	4	the	the	DET
bam-5830	360	5	expression	expression	NOUN
bam-5830	360	6	of	of	ADP
bam-5830	360	7	plin2	plin2	NOUN
bam-5830	360	8	in	in	ADP
bam-5830	360	9	adult	adult	NOUN
bam-5830	360	10	mice	mouse	NOUN
bam-5830	360	11	where	where	SCONJ
bam-5830	360	12	muscle	muscle	NOUN
bam-5830	360	13	atrophy	atrophy	NOUN
bam-5830	360	14	was	be	AUX
bam-5830	360	15	induced	induce	VERB
bam-5830	360	16	by	by	ADP
bam-5830	360	17	denervation	denervation	NOUN
bam-5830	360	18	.	.	PUNCT
bam-5830	361	1	denervation	denervation	NOUN
bam-5830	361	2	of	of	ADP
bam-5830	361	3	tibialis	tibialis	PROPN
bam-5830	361	4	anterior	anterior	ADJ
bam-5830	361	5	muscle	muscle	NOUN
bam-5830	361	6	was	be	AUX
bam-5830	361	7	compared	compare	VERB
bam-5830	361	8	with	with	ADP
bam-5830	361	9	the	the	DET
bam-5830	361	10	contralateral	contralateral	ADJ
bam-5830	361	11	intact	intact	ADJ
bam-5830	361	12	side	side	NOUN
bam-5830	361	13	.	.	PUNCT
bam-5830	362	1	after	after	ADP
bam-5830	362	2	denervation	denervation	NOUN
bam-5830	362	3	,	,	PUNCT
bam-5830	362	4	beside	beside	ADP
bam-5830	362	5	the	the	DET
bam-5830	362	6	expected	expect	VERB
bam-5830	362	7	increase	increase	NOUN
bam-5830	362	8	of	of	ADP
bam-5830	362	9	murf-1	murf-1	PROPN
bam-5830	362	10	and	and	CCONJ
bam-5830	362	11	atrogin	atrogin	NOUN
bam-5830	362	12	,	,	PUNCT
bam-5830	362	13	also	also	ADV
bam-5830	362	14	plin2	plin2	NOUN
bam-5830	362	15	expression	expression	NOUN
bam-5830	362	16	actually	actually	ADV
bam-5830	362	17	increases	increase	VERB
bam-5830	362	18	.	.	PUNCT
bam-5830	363	1	this	this	PRON
bam-5830	363	2	suggested	suggest	VERB
bam-5830	363	3	that	that	SCONJ
bam-5830	363	4	plin2	plin2	NOUN
bam-5830	363	5	expression	expression	NOUN
bam-5830	363	6	is	be	AUX
bam-5830	363	7	somehow	somehow	ADV
bam-5830	363	8	associated	associate	VERB
bam-5830	363	9	with	with	ADP
bam-5830	363	10	muscle	muscle	NOUN
bam-5830	363	11	atrophy	atrophy	NOUN
bam-5830	363	12	.	.	PUNCT
bam-5830	364	1	to	to	PART
bam-5830	364	2	support	support	VERB
bam-5830	364	3	this	this	DET
bam-5830	364	4	hypothesis	hypothesis	NOUN
bam-5830	364	5	,	,	PUNCT
bam-5830	364	6	we	we	PRON
bam-5830	364	7	performed	perform	VERB
bam-5830	364	8	muscle	muscle	NOUN
bam-5830	364	9	-	-	PUNCT
bam-5830	364	10	specific	specific	NOUN
bam-5830	364	11	in	in	ADP
bam-5830	364	12	vivo	vivo	NOUN
bam-5830	364	13	silencing	silence	VERB
bam-5830	364	14	experiments	experiment	NOUN
bam-5830	364	15	of	of	ADP
bam-5830	364	16	plin2	plin2	NOUN
bam-5830	364	17	.	.	PUNCT
bam-5830	365	1	after	after	ADP
bam-5830	365	2	7	7	NUM
bam-5830	365	3	days	day	NOUN
bam-5830	365	4	from	from	ADP
bam-5830	365	5	injection	injection	NOUN
bam-5830	365	6	,	,	PUNCT
bam-5830	365	7	a	a	DET
bam-5830	365	8	decrease	decrease	NOUN
bam-5830	365	9	of	of	ADP
bam-5830	365	10	plin2	plin2	NOUN
bam-5830	365	11	was	be	AUX
bam-5830	365	12	observed	observe	VERB
bam-5830	365	13	,	,	PUNCT
bam-5830	365	14	and	and	CCONJ
bam-5830	365	15	most	most	ADV
bam-5830	365	16	interestingly	interestingly	ADV
bam-5830	365	17	the	the	DET
bam-5830	365	18	cross	cross	ADJ
bam-5830	365	19	-	-	ADJ
bam-5830	365	20	sectional	sectional	ADJ
bam-5830	365	21	area	area	NOUN
bam-5830	365	22	(	(	PUNCT
bam-5830	365	23	csa	csa	PROPN
bam-5830	365	24	)	)	PUNCT
bam-5830	365	25	of	of	ADP
bam-5830	365	26	plin2	plin2	ADJ
bam-5830	365	27	-	-	PUNCT
bam-5830	365	28	negative	negative	ADJ
bam-5830	365	29	fibres	fibre	NOUN
bam-5830	365	30	resulted	result	VERB
bam-5830	365	31	increased	increase	VERB
bam-5830	365	32	of	of	ADP
bam-5830	365	33	about	about	ADV
bam-5830	365	34	30	30	NUM
bam-5830	365	35	%	%	NOUN
bam-5830	365	36	with	with	ADP
bam-5830	365	37	respect	respect	NOUN
bam-5830	365	38	to	to	ADP
bam-5830	365	39	plin2	plin2	NOUN
bam-5830	365	40	-	-	PUNCT
bam-5830	365	41	positive	positive	ADJ
bam-5830	365	42	ones	one	NOUN
bam-5830	365	43	.	.	PUNCT
bam-5830	366	1	as	as	ADP
bam-5830	366	2	a	a	DET
bam-5830	366	3	whole	whole	NOUN
bam-5830	366	4	,	,	PUNCT
bam-5830	366	5	these	these	DET
bam-5830	366	6	data	datum	NOUN
bam-5830	366	7	suggest	suggest	VERB
bam-5830	366	8	that	that	SCONJ
bam-5830	366	9	in	in	ADP
bam-5830	366	10	skeletal	skeletal	ADJ
bam-5830	366	11	muscle	muscle	NOUN
bam-5830	366	12	plin2	plin2	NOUN
bam-5830	366	13	is	be	AUX
bam-5830	366	14	involved	involve	VERB
bam-5830	366	15	not	not	PART
bam-5830	366	16	only	only	ADV
bam-5830	366	17	in	in	ADP
bam-5830	366	18	muscle	muscle	NOUN
bam-5830	366	19	atrophy	atrophy	NOUN
bam-5830	366	20	,	,	PUNCT
bam-5830	366	21	but	but	CCONJ
bam-5830	366	22	also	also	ADV
bam-5830	366	23	in	in	ADP
bam-5830	366	24	hypertrophy	hypertrophy	NOUN
bam-5830	366	25	.	.	PUNCT
bam-5830	367	1	further	further	ADJ
bam-5830	367	2	studies	study	NOUN
bam-5830	367	3	are	be	AUX
bam-5830	367	4	ongoing	ongoing	ADJ
bam-5830	367	5	to	to	PART
bam-5830	367	6	better	well	ADV
bam-5830	367	7	clarify	clarify	VERB
bam-5830	367	8	this	this	DET
bam-5830	367	9	new	new	ADJ
bam-5830	367	10	role	role	NOUN
bam-5830	367	11	of	of	ADP
bam-5830	367	12	plin2	plin2	NOUN
bam-5830	367	13	in	in	ADP
bam-5830	367	14	skeletal	skeletal	ADJ
bam-5830	367	15	muscle	muscle	NOUN
bam-5830	367	16	.	.	PUNCT
bam-5830	368	1	*	*	PUNCT
bam-5830	368	2	*	*	PUNCT
bam-5830	368	3	*	*	PUNCT
bam-5830	368	4	*	*	AUX
bam-5830	368	5	*	*	AUX
bam-5830	368	6	investigating	investigate	VERB
bam-5830	368	7	the	the	DET
bam-5830	368	8	cell	cell	NOUN
bam-5830	368	9	origin	origin	NOUN
bam-5830	368	10	and	and	CCONJ
bam-5830	368	11	heterogeneity	heterogeneity	NOUN
bam-5830	368	12	of	of	ADP
bam-5830	368	13	embryonal	embryonal	ADJ
bam-5830	368	14	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-5830	368	15	l.l	l.l	PROPN
bam-5830	368	16	.	.	PROPN
bam-5830	368	17	petrilli	petrilli	PROPN
bam-5830	368	18	,	,	PUNCT
bam-5830	368	19	c.	c.	PROPN
bam-5830	368	20	fuoco	fuoco	PROPN
bam-5830	368	21	,	,	PUNCT
bam-5830	368	22	l.	l.	PROPN
bam-5830	368	23	castagnoli	castagnoli	PROPN
bam-5830	368	24	,	,	PUNCT
bam-5830	368	25	c.	c.	PROPN
bam-5830	368	26	gargioli	gargioli	PROPN
bam-5830	368	27	,	,	PUNCT
bam-5830	368	28	g.	g.	PROPN
bam-5830	368	29	cesareni	cesareni	PROPN
bam-5830	368	30	department	department	PROPN
bam-5830	368	31	of	of	ADP
bam-5830	368	32	biology	biology	NOUN
bam-5830	368	33	,	,	PUNCT
bam-5830	368	34	rome	rome	PROPN
bam-5830	368	35	university	university	NOUN
bam-5830	368	36	tor	tor	PROPN
bam-5830	368	37	vergata	vergata	PROPN
bam-5830	368	38	,	,	PUNCT
bam-5830	368	39	italy	italy	PROPN
bam-5830	368	40	e	e	PROPN
bam-5830	368	41	-	-	NOUN
bam-5830	368	42	mail	mail	NOUN
bam-5830	368	43	:	:	PUNCT
bam-5830	368	44	lucialisa.petrilli@gmail.com	lucialisa.petrilli@gmail.com	X
bam-5830	368	45	the	the	DET
bam-5830	368	46	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-5830	368	47	(	(	PUNCT
bam-5830	368	48	rms	rm	NOUN
bam-5830	368	49	)	)	PUNCT
bam-5830	368	50	is	be	AUX
bam-5830	368	51	the	the	DET
bam-5830	368	52	most	most	ADV
bam-5830	368	53	common	common	ADJ
bam-5830	368	54	soft	soft	ADJ
bam-5830	368	55	tissue	tissue	NOUN
bam-5830	368	56	sarcoma	sarcoma	NOUN
bam-5830	368	57	in	in	ADP
bam-5830	368	58	people	people	NOUN
bam-5830	368	59	under	under	ADP
bam-5830	368	60	20	20	NUM
bam-5830	368	61	years	year	NOUN
bam-5830	368	62	of	of	ADP
bam-5830	368	63	age	age	NOUN
bam-5830	368	64	.	.	PUNCT
bam-5830	369	1	it	it	PRON
bam-5830	369	2	can	can	AUX
bam-5830	369	3	commonly	commonly	ADV
bam-5830	369	4	arise	arise	VERB
bam-5830	369	5	anywhere	anywhere	ADV
bam-5830	369	6	in	in	ADP
bam-5830	369	7	the	the	DET
bam-5830	369	8	body	body	NOUN
bam-5830	369	9	but	but	CCONJ
bam-5830	369	10	the	the	DET
bam-5830	369	11	head	head	NOUN
bam-5830	369	12	and	and	CCONJ
bam-5830	369	13	neck	neck	NOUN
bam-5830	369	14	,	,	PUNCT
bam-5830	369	15	the	the	DET
bam-5830	369	16	extremities	extremity	NOUN
bam-5830	369	17	and	and	CCONJ
bam-5830	369	18	the	the	DET
bam-5830	369	19	genitourinary	genitourinary	ADJ
bam-5830	369	20	tract	tract	NOUN
bam-5830	369	21	are	be	AUX
bam-5830	369	22	predominant	predominant	ADJ
bam-5830	369	23	sites	site	NOUN
bam-5830	369	24	.	.	PUNCT
bam-5830	369	25	
 	
 	SPACE
bam-5830	370	1	based	base	VERB
bam-5830	370	2	on	on	ADP
bam-5830	370	3	histology	histology	NOUN
bam-5830	370	4	,	,	PUNCT
bam-5830	370	5	rms	rm	NOUN
bam-5830	370	6	tumors	tumor	NOUN
bam-5830	370	7	are	be	AUX
bam-5830	370	8	classified	classify	VERB
bam-5830	370	9	into	into	ADP
bam-5830	370	10	two	two	NUM
bam-5830	370	11	major	major	ADJ
bam-5830	370	12	subtypes	subtype	NOUN
bam-5830	370	13	,	,	PUNCT
bam-5830	370	14	embryonal	embryonal	ADJ
bam-5830	370	15	and	and	CCONJ
bam-5830	370	16	alveolar	alveolar	ADJ
bam-5830	370	17	,	,	PUNCT
bam-5830	370	18	which	which	PRON
bam-5830	370	19	also	also	ADV
bam-5830	370	20	differ	differ	VERB
bam-5830	370	21	in	in	ADP
bam-5830	370	22	the	the	DET
bam-5830	370	23	molecular	molecular	ADJ
bam-5830	370	24	pathogenesis	pathogenesis	NOUN
bam-5830	370	25	of	of	ADP
bam-5830	370	26	development	development	NOUN
bam-5830	370	27	.	.	PUNCT
bam-5830	371	1	despite	despite	SCONJ
bam-5830	371	2	these	these	DET
bam-5830	371	3	differences	difference	NOUN
bam-5830	371	4	,	,	PUNCT
bam-5830	371	5	the	the	DET
bam-5830	371	6	origin	origin	NOUN
bam-5830	371	7	of	of	ADP
bam-5830	371	8	arms	arm	NOUN
bam-5830	371	9	and	and	CCONJ
bam-5830	371	10	erms	erm	NOUN
bam-5830	371	11	seems	seem	VERB
bam-5830	371	12	to	to	PART
bam-5830	371	13	be	be	AUX
bam-5830	371	14	the	the	DET
bam-5830	371	15	same	same	ADJ
bam-5830	371	16	but	but	CCONJ
bam-5830	371	17	the	the	DET
bam-5830	371	18	precise	precise	ADJ
bam-5830	371	19	cell	cell	NOUN
bam-5830	371	20	type	type	NOUN
bam-5830	371	21	that	that	PRON
bam-5830	371	22	triggers	trigger	VERB
bam-5830	371	23	rms	rm	NOUN
bam-5830	371	24	is	be	AUX
bam-5830	371	25	still	still	ADV
bam-5830	371	26	unclear	unclear	ADJ
bam-5830	371	27	.	.	PUNCT
bam-5830	372	1	some	some	DET
bam-5830	372	2	evidence	evidence	NOUN
bam-5830	372	3	supports	support	VERB
bam-5830	372	4	the	the	DET
bam-5830	372	5	notion	notion	NOUN
bam-5830	372	6	that	that	SCONJ
bam-5830	372	7	skeletal	skeletal	ADJ
bam-5830	372	8	muscle	muscle	NOUN
bam-5830	372	9	precursors	precursor	NOUN
bam-5830	372	10	,	,	PUNCT
bam-5830	372	11	probably	probably	ADV
bam-5830	372	12	satellite	satellite	NOUN
bam-5830	372	13	cells	cell	NOUN
bam-5830	372	14	,	,	PUNCT
bam-5830	372	15	may	may	AUX
bam-5830	372	16	initiate	initiate	VERB
bam-5830	372	17	rms	rm	NOUN
bam-5830	372	18	.	.	PUNCT
bam-5830	373	1	alternative	alternative	ADJ
bam-5830	373	2	theories	theory	NOUN
bam-5830	373	3	propose	propose	VERB
bam-5830	373	4	mesenchymal	mesenchymal	ADJ
bam-5830	373	5	stem	stem	NOUN
bam-5830	373	6	cells	cell	NOUN
bam-5830	373	7	,	,	PUNCT
bam-5830	373	8	or	or	CCONJ
bam-5830	373	9	even	even	ADV
bam-5830	373	10	cells	cell	NOUN
bam-5830	373	11	belonging	belong	VERB
bam-5830	373	12	to	to	ADP
bam-5830	373	13	the	the	DET
bam-5830	373	14	adipocyte	adipocyte	ADJ
bam-5830	373	15	lineage	lineage	NOUN
bam-5830	373	16	,	,	PUNCT
bam-5830	373	17	as	as	ADP
bam-5830	373	18	possible	possible	ADJ
bam-5830	373	19	tumor	tumor	NOUN
bam-5830	373	20	-	-	PUNCT
bam-5830	373	21	initiating	initiate	VERB
bam-5830	373	22	cells	cell	NOUN
bam-5830	373	23	.	.	PUNCT
bam-5830	374	1	in	in	ADP
bam-5830	374	2	order	order	NOUN
bam-5830	374	3	to	to	PART
bam-5830	374	4	shed	shed	VERB
bam-5830	374	5	light	light	NOUN
bam-5830	374	6	on	on	ADP
bam-5830	374	7	the	the	DET
bam-5830	374	8	origin	origin	NOUN
bam-5830	374	9	of	of	ADP
bam-5830	374	10	erms	erm	NOUN
bam-5830	374	11	,	,	PUNCT
bam-5830	374	12	we	we	PRON
bam-5830	374	13	adopted	adopt	VERB
bam-5830	374	14	the	the	DET
bam-5830	374	15	krasg12d/+trp53fl	krasg12d/+trp53fl	PROPN
bam-5830	374	16	/	/	SYM
bam-5830	374	17	fl	fl	PROPN
bam-5830	374	18	conditional	conditional	PROPN
bam-5830	374	19	mouse	mouse	NOUN
bam-5830	374	20	model	model	NOUN
bam-5830	374	21	.	.	PUNCT
bam-5830	375	1	this	this	DET
bam-5830	375	2	model	model	NOUN
bam-5830	375	3	allows	allow	VERB
bam-5830	375	4	us	we	PRON
bam-5830	375	5	to	to	PART
bam-5830	375	6	generate	generate	VERB
bam-5830	375	7	erms	erm	NOUN
bam-5830	375	8	in	in	ADP
bam-5830	375	9	the	the	DET
bam-5830	375	10	hind	hind	NOUN
bam-5830	375	11	limb	limb	NOUN
bam-5830	375	12	of	of	ADP
bam-5830	375	13	mice	mouse	NOUN
bam-5830	375	14	by	by	ADP
bam-5830	375	15	infecting	infect	VERB
bam-5830	375	16	them	they	PRON
bam-5830	375	17	with	with	ADP
bam-5830	375	18	an	an	DET
bam-5830	375	19	adenovirus	adenovirus	NOUN
bam-5830	375	20	vector	vector	NOUN
bam-5830	375	21	carrying	carry	VERB
bam-5830	375	22	the	the	DET
bam-5830	375	23	cre	cre	PROPN
bam-5830	375	24	recombinase	recombinase	NOUN
bam-5830	375	25	.	.	PUNCT
bam-5830	375	26	
 	
 	SPACE
bam-5830	375	27	in	in	ADP
bam-5830	375	28	a	a	DET
bam-5830	375	29	first	first	ADJ
bam-5830	375	30	approach	approach	NOUN
bam-5830	375	31	we	we	PRON
bam-5830	375	32	want	want	VERB
bam-5830	375	33	to	to	PART
bam-5830	375	34	describe	describe	VERB
bam-5830	375	35	and	and	CCONJ
bam-5830	375	36	rationalize	rationalize	VERB
bam-5830	375	37	the	the	DET
bam-5830	375	38	changes	change	NOUN
bam-5830	375	39	in	in	ADP
bam-5830	375	40	the	the	DET
bam-5830	375	41	tumor	tumor	NOUN
bam-5830	375	42	mass	mass	NOUN
bam-5830	375	43	cell	cell	NOUN
bam-5830	375	44	populations	population	NOUN
bam-5830	375	45	by	by	ADP
bam-5830	375	46	analyzing	analyze	VERB
bam-5830	375	47	the	the	DET
bam-5830	375	48	tumor	tumor	NOUN
bam-5830	375	49	at	at	ADP
bam-5830	375	50	different	different	ADJ
bam-5830	375	51	stages	stage	NOUN
bam-5830	375	52	of	of	ADP
bam-5830	375	53	development	development	NOUN
bam-5830	375	54	by	by	ADP
bam-5830	375	55	using	use	VERB
bam-5830	375	56	flow	flow	NOUN
bam-5830	375	57	and	and	CCONJ
bam-5830	375	58	mass	mass	ADJ
bam-5830	375	59	cytometry	cytometry	NOUN
bam-5830	375	60	techniques	technique	NOUN
bam-5830	375	61	.	.	PUNCT
bam-5830	376	1	in	in	ADP
bam-5830	376	2	a	a	DET
bam-5830	376	3	second	second	ADJ
bam-5830	376	4	approach	approach	NOUN
bam-5830	376	5	we	we	PRON
bam-5830	376	6	aim	aim	VERB
bam-5830	376	7	at	at	ADP
bam-5830	376	8	identifying	identify	VERB
bam-5830	376	9	the	the	DET
bam-5830	376	10	cell	cell	NOUN
bam-5830	376	11	population(s	population(s	NOUN
bam-5830	376	12	)	)	PUNCT
bam-5830	376	13	that	that	PRON
bam-5830	376	14	are	be	AUX
bam-5830	376	15	responsible	responsible	ADJ
bam-5830	376	16	for	for	ADP
bam-5830	376	17	initiating	initiate	VERB
bam-5830	376	18	the	the	DET
bam-5830	376	19	tumor	tumor	NOUN
bam-5830	376	20	.	.	PUNCT
bam-5830	377	1	to	to	ADP
bam-5830	377	2	this	this	DET
bam-5830	377	3	end	end	NOUN
bam-5830	377	4	we	we	PRON
bam-5830	377	5	induce	induce	VERB
bam-5830	377	6	the	the	DET
bam-5830	377	7	gene	gene	NOUN
bam-5830	377	8	mutations	mutation	NOUN
bam-5830	377	9	that	that	PRON
bam-5830	377	10	are	be	AUX
bam-5830	377	11	responsible	responsible	ADJ
bam-5830	377	12	for	for	ADP
bam-5830	377	13	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-5830	377	14	development	development	NOUN
bam-5830	377	15	by	by	ADP
bam-5830	377	16	infecting	infect	VERB
bam-5830	377	17	,	,	PUNCT
bam-5830	377	18	with	with	ADP
bam-5830	377	19	the	the	DET
bam-5830	377	20	cre	cre	PROPN
bam-5830	377	21	recombinase	recombinase	NOUN
bam-5830	377	22	adenovirus	adenovirus	NOUN
bam-5830	377	23	,	,	PUNCT
bam-5830	377	24	isolated	isolated	ADJ
bam-5830	377	25	muscle	muscle	NOUN
bam-5830	377	26	mononucleate	mononucleate	NOUN
bam-5830	377	27	cell	cell	NOUN
bam-5830	377	28	populations	population	NOUN
bam-5830	377	29	and	and	CCONJ
bam-5830	377	30	monitor	monitor	VERB
bam-5830	377	31	their	their	PRON
bam-5830	377	32	ability	ability	NOUN
bam-5830	377	33	to	to	PART
bam-5830	377	34	develop	develop	VERB
bam-5830	377	35	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-5830	377	36	tumorigenic	tumorigenic	ADJ
bam-5830	377	37	properties	property	NOUN
bam-5830	377	38	in	in	ADP
bam-5830	377	39	vitro	vitro	VERB
bam-5830	377	40	.	.	PUNCT
bam-5830	378	1	*	*	PUNCT
bam-5830	379	1	*	*	PUNCT
bam-5830	379	2	*	*	PUNCT
bam-5830	379	3	*	*	PUNCT
bam-5830	379	4	*	*	PUNCT
bam-5830	379	5	murc	murc	PROPN
bam-5830	379	6	/	/	SYM
bam-5830	379	7	cavin-4	cavin-4	PROPN
bam-5830	379	8	is	be	AUX
bam-5830	379	9	co	co	VERB
bam-5830	379	10	-	-	VERB
bam-5830	379	11	expressed	express	VERB
bam-5830	379	12	with	with	ADP
bam-5830	379	13	caveolin-3	caveolin-3	PROPN
bam-5830	379	14	in	in	ADP
bam-5830	379	15	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-5830	379	16	tumors	tumor	NOUN
bam-5830	379	17	and	and	CCONJ
bam-5830	379	18	its	its	PRON
bam-5830	379	19	silencing	silence	VERB
bam-5830	379	20	prevents	prevent	VERB
bam-5830	379	21	myogenic	myogenic	ADJ
bam-5830	379	22	differentiation	differentiation	NOUN
bam-5830	379	23	in	in	ADP
bam-5830	379	24	the	the	DET
bam-5830	379	25	human	human	ADJ
bam-5830	379	26	embryonal	embryonal	PROPN
bam-5830	379	27	rd	rd	PROPN
bam-5830	379	28	cell	cell	NOUN
bam-5830	379	29	line	line	NOUN
bam-5830	379	30	s.	s.	PROPN
bam-5830	379	31	codenotti	codenotti	PROPN
bam-5830	379	32	1,2	1,2	NUM
bam-5830	379	33	,	,	PUNCT
bam-5830	379	34	f.	f.	PROPN
bam-5830	379	35	faggi	faggi	PROPN
bam-5830	379	36	2	2	NUM
bam-5830	379	37	,	,	PUNCT
bam-5830	379	38	p.	p.	NOUN
bam-5830	379	39	l.	l.	PROPN
bam-5830	380	1	poliani	poliani	PROPN
bam-5830	380	2	1	1	NUM
bam-5830	380	3	,	,	PUNCT
bam-5830	380	4	m.	m.	NOUN
bam-5830	380	5	cominelli	cominelli	PROPN
bam-5830	380	6	1	1	NUM
bam-5830	380	7	,	,	PUNCT
bam-5830	380	8	n.	n.	NOUN
bam-5830	380	9	chiarelli	chiarelli	PROPN
bam-5830	380	10	1	1	NUM
bam-5830	380	11	,	,	PUNCT
bam-5830	380	12	m.	m.	NOUN
bam-5830	380	13	colombi	colombi	PROPN
bam-5830	380	14	1	1	NUM
bam-5830	380	15	,	,	PUNCT
bam-5830	380	16	m.	m.	NOUN
bam-5830	380	17	vezzoli	vezzoli	PROPN
bam-5830	380	18	1	1	NUM
bam-5830	380	19	,	,	PUNCT
bam-5830	380	20	e.	e.	PROPN
bam-5830	380	21	monti	monti	PROPN
bam-5830	380	22	1	1	PROPN
bam-5830	380	23	,	,	PUNCT
bam-5830	380	24	f.	f.	PROPN
bam-5830	380	25	bono	bono	X
bam-5830	380	26	1	1	NUM
bam-5830	380	27	,	,	PUNCT
bam-5830	380	28	g.	g.	PROPN
bam-5830	380	29	tulipano	tulipano	PROPN
bam-5830	380	30	1	1	NUM
bam-5830	380	31	,	,	PUNCT
bam-5830	380	32	c.	c.	PROPN
bam-5830	380	33	fiorentini	fiorentini	PROPN
bam-5830	380	34	1	1	NUM
bam-5830	380	35	,	,	PUNCT
bam-5830	380	36	a.	a.	PROPN
bam-5830	380	37	zanola	zanola	PROPN
bam-5830	380	38	1	1	NUM
bam-5830	380	39	,	,	PUNCT
bam-5830	380	40	s.	s.	PROPN
bam-5830	380	41	gavazzi	gavazzi	PROPN
bam-5830	380	42	1	1	NUM
bam-5830	380	43	,	,	PUNCT
bam-5830	381	1	h.	h.	PROPN
bam-5830	381	2	p.	p.	PROPN
bam-5830	381	3	lo	lo	PROPN
bam-5830	382	1	3	3	NUM
bam-5830	382	2	,	,	PUNCT
bam-5830	382	3	r.	r.	PROPN
bam-5830	382	4	g.	g.	PROPN
bam-5830	382	5	parton	parton	PROPN
bam-5830	382	6	3	3	NUM
bam-5830	382	7	,	,	PUNCT
bam-5830	382	8	c.	c.	PROPN
bam-5830	382	9	keller	keller	PROPN
bam-5830	382	10	4,5	4,5	NUM
bam-5830	382	11	,	,	PUNCT
bam-5830	382	12	a.	a.	NOUN
bam-5830	382	13	fanzani	fanzani	PROPN
bam-5830	382	14	1,2	1,2	NUM
bam-5830	382	15	1	1	NUM
bam-5830	382	16	.	.	PUNCT
bam-5830	383	1	department	department	NOUN
bam-5830	383	2	of	of	ADP
bam-5830	383	3	molecular	molecular	ADJ
bam-5830	383	4	and	and	CCONJ
bam-5830	383	5	translational	translational	ADJ
bam-5830	383	6	medicine	medicine	NOUN
bam-5830	383	7	,	,	PUNCT
bam-5830	383	8	university	university	NOUN
bam-5830	383	9	of	of	ADP
bam-5830	383	10	brescia	brescia	PROPN
bam-5830	383	11	,	,	PUNCT
bam-5830	383	12	italy	italy	PROPN
bam-5830	383	13	;	;	PUNCT
bam-5830	383	14	2	2	X
bam-5830	383	15	.	.	X
bam-5830	383	16	interuniversity	interuniversity	PROPN
bam-5830	383	17	institute	institute	PROPN
bam-5830	383	18	of	of	ADP
bam-5830	383	19	myology	myology	NOUN
bam-5830	383	20	(	(	PUNCT
bam-5830	383	21	iim	iim	NOUN
bam-5830	383	22	)	)	PUNCT
bam-5830	383	23	,	,	PUNCT
bam-5830	383	24	rome	rome	PROPN
bam-5830	383	25	,	,	PUNCT
bam-5830	383	26	italy	italy	PROPN
bam-5830	383	27	;	;	PUNCT
bam-5830	383	28	3	3	X
bam-5830	383	29	.	.	X
bam-5830	383	30	institute	institute	NOUN
bam-5830	383	31	for	for	ADP
bam-5830	383	32	molecular	molecular	ADJ
bam-5830	383	33	bioscience	bioscience	NOUN
bam-5830	383	34	,	,	PUNCT
bam-5830	383	35	university	university	PROPN
bam-5830	383	36	of	of	ADP
bam-5830	383	37	queensland	queensland	PROPN
bam-5830	383	38	,	,	PUNCT
bam-5830	383	39	brisbane	brisbane	PROPN
bam-5830	383	40	,	,	PUNCT
bam-5830	383	41	queensland	queensland	PROPN
bam-5830	383	42	,	,	PUNCT
bam-5830	383	43	australia	australia	PROPN
bam-5830	383	44	;	;	PUNCT
bam-5830	383	45	4	4	X
bam-5830	383	46	.	.	X
bam-5830	383	47	department	department	NOUN
bam-5830	383	48	of	of	ADP
bam-5830	383	49	pediatrics	pediatric	NOUN
bam-5830	383	50	,	,	PUNCT
bam-5830	383	51	oregon	oregon	PROPN
bam-5830	383	52	health	health	PROPN
bam-5830	383	53	&	&	CCONJ
bam-5830	383	54	science	science	PROPN
bam-5830	383	55	university	university	PROPN
bam-5830	383	56	,	,	PUNCT
bam-5830	383	57	portland	portland	PROPN
bam-5830	383	58	,	,	PUNCT
bam-5830	383	59	or	or	CCONJ
bam-5830	383	60	,	,	PUNCT
bam-5830	383	61	usa	usa	PROPN
bam-5830	383	62	;	;	PUNCT
bam-5830	383	63	5	5	NUM
bam-5830	383	64	.	.	PUNCT
bam-5830	383	65	children	child	NOUN
bam-5830	383	66	s	s	PART
bam-5830	383	67	cancer	cancer	NOUN
bam-5830	383	68	therapy	therapy	PROPN
bam-5830	383	69	development	development	PROPN
bam-5830	383	70	institute	institute	PROPN
bam-5830	383	71	,	,	PUNCT
bam-5830	383	72	fort	fort	PROPN
bam-5830	383	73	collins	collins	PROPN
bam-5830	383	74	,	,	PUNCT
bam-5830	383	75	co	co	PROPN
bam-5830	383	76	,	,	PUNCT
bam-5830	383	77	usa	usa	PROPN
bam-5830	383	78	e	e	PROPN
bam-5830	383	79	-	-	NOUN
bam-5830	383	80	mail	mail	NOUN
bam-5830	383	81	:	:	PUNCT
bam-5830	384	1	silviacodenotti90@gmail.com	silviacodenotti90@gmail.com	X
bam-5830	384	2	the	the	DET
bam-5830	384	3	purpose	purpose	NOUN
bam-5830	384	4	of	of	ADP
bam-5830	384	5	this	this	DET
bam-5830	384	6	study	study	NOUN
bam-5830	384	7	was	be	AUX
bam-5830	384	8	to	to	PART
bam-5830	384	9	investigate	investigate	VERB
bam-5830	384	10	whether	whether	SCONJ
bam-5830	384	11	murc	murc	NOUN
bam-5830	384	12	/	/	SYM
bam-5830	384	13	cavin-4	cavin-4	PROPN
bam-5830	384	14	,	,	PUNCT
bam-5830	384	15	a	a	DET
bam-5830	384	16	plasma	plasma	NOUN
bam-5830	384	17	membrane	membrane	NOUN
bam-5830	384	18	and	and	CCONJ
bam-5830	384	19	z	z	NOUN
bam-5830	384	20	-	-	PUNCT
bam-5830	384	21	line	line	NOUN
bam-5830	384	22	associated	associate	VERB
bam-5830	384	23	protein	protein	NOUN
bam-5830	384	24	exhibiting	exhibit	VERB
bam-5830	384	25	an	an	DET
bam-5830	384	26	overlapping	overlap	VERB
bam-5830	384	27	distribution	distribution	NOUN
bam-5830	384	28	with	with	ADP
bam-5830	384	29	caveolin3	caveolin3	PROPN
bam-5830	384	30	(	(	PUNCT
bam-5830	384	31	cav-3	cav-3	NOUN
bam-5830	384	32	)	)	PUNCT
bam-5830	384	33	in	in	ADP
bam-5830	384	34	heart	heart	NOUN
bam-5830	384	35	and	and	CCONJ
bam-5830	384	36	muscle	muscle	NOUN
bam-5830	384	37	tissues	tissue	NOUN
bam-5830	384	38	,	,	PUNCT
bam-5830	384	39	may	may	AUX
bam-5830	384	40	be	be	AUX
bam-5830	384	41	expressed	express	VERB
bam-5830	384	42	and	and	CCONJ
bam-5830	384	43	play	play	VERB
bam-5830	384	44	a	a	DET
bam-5830	384	45	role	role	NOUN
bam-5830	384	46	in	in	ADP
bam-5830	384	47	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-5830	384	48	(	(	PUNCT
bam-5830	384	49	rms	rm	NOUN
bam-5830	384	50	)	)	PUNCT
bam-5830	384	51	,	,	PUNCT
bam-5830	384	52	an	an	DET
bam-5830	384	53	aggressive	aggressive	ADJ
bam-5830	384	54	myogenic	myogenic	ADJ
bam-5830	384	55	tumor	tumor	NOUN
bam-5830	384	56	affecting	affect	VERB
bam-5830	384	57	childhood	childhood	NOUN
bam-5830	384	58	.	.	PUNCT
bam-5830	385	1	we	we	PRON
bam-5830	385	2	found	find	VERB
bam-5830	385	3	murc	murc	PROPN
bam-5830	385	4	/	/	SYM
bam-5830	385	5	cavin-4	cavin-4	PROPN
bam-5830	385	6	to	to	PART
bam-5830	385	7	be	be	AUX
bam-5830	385	8	expressed	express	VERB
bam-5830	385	9	,	,	PUNCT
bam-5830	385	10	often	often	ADV
bam-5830	385	11	concurrently	concurrently	ADV
bam-5830	385	12	with	with	ADP
bam-5830	385	13	cav3	cav3	PROPN
bam-5830	385	14	,	,	PUNCT
bam-5830	385	15	in	in	ADP
bam-5830	385	16	mouse	mouse	NOUN
bam-5830	385	17	and	and	CCONJ
bam-5830	385	18	human	human	ADJ
bam-5830	385	19	rms	rm	NOUN
bam-5830	385	20	,	,	PUNCT
bam-5830	385	21	as	as	SCONJ
bam-5830	385	22	demonstrated	demonstrate	VERB
bam-5830	385	23	through	through	ADP
bam-5830	385	24	in	in	ADP
bam-5830	385	25	silico	silico	NOUN
bam-5830	385	26	analysis	analysis	NOUN
bam-5830	385	27	of	of	ADP
bam-5830	385	28	gene	gene	NOUN
bam-5830	385	29	datasets	dataset	NOUN
bam-5830	385	30	and	and	CCONJ
bam-5830	385	31	immunohistochemical	immunohistochemical	ADJ
bam-5830	385	32	analysis	analysis	NOUN
bam-5830	385	33	of	of	ADP
bam-5830	385	34	tumor	tumor	NOUN
bam-5830	385	35	samples	sample	NOUN
bam-5830	385	36	.	.	PUNCT
bam-5830	386	1	in	in	ADP
bam-5830	386	2	vitro	vitro	X
bam-5830	386	3	expression	expression	NOUN
bam-5830	386	4	studies	study	NOUN
bam-5830	386	5	carried	carry	VERB
bam-5830	386	6	out	out	ADP
bam-5830	386	7	using	use	VERB
bam-5830	386	8	human	human	ADJ
bam-5830	386	9	cell	cell	NOUN
bam-5830	386	10	lines	line	NOUN
bam-5830	386	11	and	and	CCONJ
bam-5830	386	12	primary	primary	ADJ
bam-5830	386	13	mouse	mouse	NOUN
bam-5830	386	14	tumor	tumor	NOUN
bam-5830	386	15	cultures	culture	NOUN
bam-5830	386	16	showed	show	VERB
bam-5830	386	17	that	that	SCONJ
bam-5830	386	18	expression	expression	NOUN
bam-5830	386	19	levels	level	NOUN
bam-5830	386	20	of	of	ADP
bam-5830	386	21	both	both	CCONJ
bam-5830	386	22	murc	murc	NOUN
bam-5830	386	23	/	/	SYM
bam-5830	386	24	cavin-4	cavin-4	PROPN
bam-5830	386	25	and	and	CCONJ
bam-5830	386	26	cav-3	cav-3	ADV
bam-5830	386	27	,	,	PUNCT
bam-5830	386	28	while	while	SCONJ
bam-5830	386	29	being	be	AUX
bam-5830	386	30	low	low	ADJ
bam-5830	386	31	or	or	CCONJ
bam-5830	386	32	undetectable	undetectable	ADJ
bam-5830	386	33	during	during	ADP
bam-5830	386	34	cell	cell	NOUN
bam-5830	386	35	proliferation	proliferation	NOUN
bam-5830	386	36	,	,	PUNCT
bam-5830	386	37	became	became	AUX
bam-5830	386	38	robustly	robustly	ADV
bam-5830	386	39	increased	increase	VERB
bam-5830	386	40	during	during	ADP
bam-5830	386	41	myogenic	myogenic	ADJ
bam-5830	386	42	differentiation	differentiation	NOUN
bam-5830	386	43	,	,	PUNCT
bam-5830	386	44	as	as	SCONJ
bam-5830	386	45	detected	detect	VERB
bam-5830	386	46	via	via	ADP
bam-5830	386	47	semi	semi	ADJ
bam-5830	386	48	-	-	ADJ
bam-5830	386	49	quantitative	quantitative	ADJ
bam-5830	386	50	rt	rt	NOUN
bam-5830	386	51	-	-	PUNCT
bam-5830	386	52	pcr	pcr	NOUN
bam-5830	386	53	and	and	CCONJ
bam-5830	386	54	immunoblotting	immunoblotte	VERB
bam-5830	386	55	analysis	analysis	NOUN
bam-5830	386	56	.	.	PUNCT
bam-5830	387	1	furthermore	furthermore	ADV
bam-5830	387	2	,	,	PUNCT
bam-5830	387	3	confocal	confocal	ADJ
bam-5830	387	4	microscopy	microscopy	NOUN
bam-5830	387	5	analysis	analysis	NOUN
bam-5830	387	6	performed	perform	VERB
bam-5830	387	7	on	on	ADP
bam-5830	387	8	human	human	PROPN
bam-5830	387	9	rd	rd	PROPN
bam-5830	387	10	and	and	CCONJ
bam-5830	387	11	rh30	rh30	PROPN
bam-5830	387	12	cell	cell	NOUN
bam-5830	387	13	lines	line	NOUN
bam-5830	387	14	confirmed	confirm	VERB
bam-5830	387	15	that	that	SCONJ
bam-5830	387	16	murc	murc	PROPN
bam-5830	387	17	/	/	SYM
bam-5830	387	18	cavin-4	cavin-4	PRON
bam-5830	387	19	mostly	mostly	ADV
bam-5830	387	20	marks	mark	VERB
bam-5830	387	21	differentiated	differentiated	ADJ
bam-5830	387	22	cell	cell	NOUN
bam-5830	387	23	elements	element	NOUN
bam-5830	387	24	,	,	PUNCT
bam-5830	387	25	colocalizing	colocalize	VERB
bam-5830	387	26	at	at	ADP
bam-5830	387	27	the	the	DET
bam-5830	387	28	cell	cell	NOUN
bam-5830	387	29	surface	surface	NOUN
bam-5830	387	30	with	with	ADP
bam-5830	387	31	cav-3	cav-3	NOUN
bam-5830	387	32	and	and	CCONJ
bam-5830	387	33	labeling	labeling	NOUN
bam-5830	387	34	myosin	myosin	PROPN
bam-5830	387	35	heavy	heavy	PROPN
bam-5830	387	36	chain	chain	NOUN
bam-5830	387	37	(	(	PUNCT
bam-5830	387	38	mhc	mhc	PROPN
bam-5830	387	39	)	)	PUNCT
bam-5830	387	40	expressing	express	VERB
bam-5830	387	41	cells	cell	NOUN
bam-5830	387	42	.	.	PUNCT
bam-5830	388	1	finally	finally	ADV
bam-5830	388	2	,	,	PUNCT
bam-5830	388	3	murc	murc	PROPN
bam-5830	388	4	/	/	SYM
bam-5830	388	5	cavin-4	cavin-4	PRON
bam-5830	388	6	silencing	silence	VERB
bam-5830	388	7	prevented	prevent	VERB
bam-5830	388	8	the	the	DET
bam-5830	388	9	differentiation	differentiation	NOUN
bam-5830	388	10	in	in	ADP
bam-5830	388	11	the	the	DET
bam-5830	388	12	rd	rd	NOUN
bam-5830	388	13	cell	cell	NOUN
bam-5830	388	14	line	line	NOUN
bam-5830	388	15	,	,	PUNCT
bam-5830	388	16	leading	lead	VERB
bam-5830	388	17	to	to	ADP
bam-5830	388	18	morphological	morphological	ADJ
bam-5830	388	19	cell	cell	NOUN
bam-5830	388	20	impairment	impairment	NOUN
bam-5830	388	21	characterized	characterize	VERB
bam-5830	388	22	by	by	ADP
bam-5830	388	23	depletion	depletion	NOUN
bam-5830	388	24	of	of	ADP
bam-5830	388	25	myogenin	myogenin	PROPN
bam-5830	388	26	,	,	PUNCT
bam-5830	388	27	cav-3	cav-3	NOUN
bam-5830	388	28	and	and	CCONJ
bam-5830	388	29	mhc	mhc	PROPN
bam-5830	388	30	protein	protein	NOUN
bam-5830	388	31	levels	level	NOUN
bam-5830	388	32	.	.	PUNCT
bam-5830	389	1	overall	overall	ADV
bam-5830	389	2	,	,	PUNCT
bam-5830	389	3	our	our	PRON
bam-5830	389	4	data	datum	NOUN
bam-5830	389	5	suggest	suggest	VERB
bam-5830	389	6	that	that	SCONJ
bam-5830	389	7	murc	murc	PROPN
bam-5830	389	8	/	/	SYM
bam-5830	389	9	cavin-4	cavin-4	PROPN
bam-5830	389	10	,	,	PUNCT
bam-5830	389	11	especially	especially	ADV
bam-5830	389	12	in	in	ADP
bam-5830	389	13	combination	combination	NOUN
bam-5830	389	14	with	with	ADP
bam-5830	389	15	cav-3	cav-3	NOUN
bam-5830	389	16	,	,	PUNCT
bam-5830	389	17	may	may	AUX
bam-5830	389	18	play	play	VERB
bam-5830	389	19	a	a	DET
bam-5830	389	20	consistent	consistent	ADJ
bam-5830	389	21	role	role	NOUN
bam-5830	389	22	in	in	ADP
bam-5830	389	23	the	the	DET
bam-5830	389	24	differentiation	differentiation	NOUN
bam-5830	389	25	process	process	NOUN
bam-5830	389	26	of	of	ADP
bam-5830	389	27	rms	rm	NOUN
bam-5830	389	28	.	.	PUNCT
bam-5830	390	1	abstracts	abstract	NOUN
bam-5830	390	2	of	of	ADP
bam-5830	390	3	the	the	DET
bam-5830	390	4	xii	xii	PROPN
bam-5830	390	5	iim	iim	NOUN
bam-5830	390	6	myology	myology	NOUN
bam-5830	390	7	meeting	meeting	NOUN
bam-5830	390	8	october	october	PROPN
bam-5830	390	9	1–4	1–4	PROPN
bam-5830	390	10	,	,	PUNCT
bam-5830	390	11	2015	2015	NUM
bam-5830	390	12	eur	eur	PROPN
bam-5830	390	13	j	j	PROPN
bam-5830	390	14	transl	transl	PROPN
bam-5830	390	15	myol	myol	PROPN
bam-5830	390	16	basic	basic	ADJ
bam-5830	390	17	appl	appl	NOUN
bam-5830	390	18	myol	myol	NOUN
bam-5830	390	19	2016	2016	NUM
bam-5830	390	20	;	;	PUNCT
bam-5830	390	21	26	26	NUM
bam-5830	390	22	(	(	PUNCT
bam-5830	390	23	1):2	1):2	NUM
bam-5830	390	24	-	-	SYM
bam-5830	390	25	24	24	NUM
bam-5830	390	26	this	this	DET
bam-5830	390	27	article	article	NOUN
bam-5830	390	28	is	be	AUX
bam-5830	390	29	distributed	distribute	VERB
bam-5830	390	30	under	under	ADP
bam-5830	390	31	the	the	DET
bam-5830	390	32	terms	term	NOUN
bam-5830	390	33	of	of	ADP
bam-5830	390	34	the	the	DET
bam-5830	390	35	creative	creative	ADJ
bam-5830	390	36	commons	common	NOUN
bam-5830	390	37	attribution	attribution	NOUN
bam-5830	390	38	noncommercial	noncommercial	ADJ
bam-5830	390	39	license	license	NOUN
bam-5830	390	40	(	(	PUNCT
bam-5830	390	41	cc	cc	NOUN
bam-5830	390	42	by	by	ADP
bam-5830	390	43	-	-	PUNCT
bam-5830	390	44	nc	nc	PROPN
bam-5830	390	45	4.0	4.0	NUM
bam-5830	390	46	)	)	PUNCT
bam-5830	390	47	which	which	PRON
bam-5830	390	48	permits	permit	VERB
bam-5830	390	49	any	any	DET
bam-5830	390	50	noncommercial	noncommercial	ADJ
bam-5830	390	51	use	use	NOUN
bam-5830	390	52	,	,	PUNCT
bam-5830	390	53	distribution	distribution	NOUN
bam-5830	390	54	,	,	PUNCT
bam-5830	390	55	and	and	CCONJ
bam-5830	390	56	reproduction	reproduction	NOUN
bam-5830	390	57	in	in	ADP
bam-5830	390	58	any	any	DET
bam-5830	390	59	medium	medium	NOUN
bam-5830	390	60	,	,	PUNCT
bam-5830	390	61	provided	provide	VERB
bam-5830	390	62	the	the	DET
bam-5830	390	63	original	original	ADJ
bam-5830	390	64	author(s	author(s	NOUN
bam-5830	390	65	)	)	PUNCT
bam-5830	390	66	and	and	CCONJ
bam-5830	390	67	source	source	NOUN
bam-5830	390	68	are	be	AUX
bam-5830	390	69	credited	credit	VERB
bam-5830	390	70	.	.	PUNCT
bam-5830	391	1	13	13	NUM
bam-5830	391	2	cavin-1	cavin-1	NUM
bam-5830	391	3	and	and	CCONJ
bam-5830	391	4	caveolin-1	caveolin-1	NUM
bam-5830	391	5	are	be	AUX
bam-5830	391	6	both	both	PRON
bam-5830	391	7	required	require	VERB
bam-5830	391	8	to	to	PART
bam-5830	391	9	support	support	VERB
bam-5830	391	10	cell	cell	NOUN
bam-5830	391	11	proliferation	proliferation	NOUN
bam-5830	391	12	,	,	PUNCT
bam-5830	391	13	migration	migration	NOUN
bam-5830	391	14	and	and	CCONJ
bam-5830	391	15	anchorage	anchorage	NOUN
bam-5830	391	16	-	-	PUNCT
bam-5830	391	17	independent	independent	ADJ
bam-5830	391	18	cell	cell	NOUN
bam-5830	391	19	growth	growth	NOUN
bam-5830	391	20	in	in	ADP
bam-5830	391	21	rhabdomyosarcoma	rhabdomyosarcoma	PROPN
bam-5830	391	22	f.	f.	PROPN
bam-5830	391	23	faggi	faggi	PROPN
bam-5830	391	24	1	1	NUM
bam-5830	391	25	,	,	PUNCT
bam-5830	391	26	n.	n.	NOUN
bam-5830	391	27	chiarelli	chiarelli	PROPN
bam-5830	391	28	1	1	NUM
bam-5830	391	29	,	,	PUNCT
bam-5830	391	30	m.	m.	NOUN
bam-5830	391	31	colombi	colombi	PROPN
bam-5830	391	32	1	1	NUM
bam-5830	391	33	,	,	PUNCT
bam-5830	391	34	s.	s.	PROPN
bam-5830	391	35	mitola	mitola	PROPN
bam-5830	391	36	1	1	NUM
bam-5830	391	37	,	,	PUNCT
bam-5830	391	38	r.	r.	PROPN
bam-5830	391	39	ronca	ronca	PROPN
bam-5830	391	40	1	1	NUM
bam-5830	391	41	,	,	PUNCT
bam-5830	391	42	l.	l.	PROPN
bam-5830	391	43	madaro	madaro	PROPN
bam-5830	391	44	2	2	NUM
bam-5830	391	45	,	,	PUNCT
bam-5830	391	46	m.	m.	NOUN
bam-5830	391	47	bouche	bouche	X
bam-5830	391	48	2	2	NUM
bam-5830	391	49	,	,	PUNCT
bam-5830	391	50	l.	l.	PROPN
bam-5830	391	51	poliani	poliani	PROPN
bam-5830	391	52	1	1	NUM
bam-5830	391	53	,	,	PUNCT
bam-5830	391	54	m.	m.	NOUN
bam-5830	391	55	vezzoli	vezzoli	PROPN
bam-5830	391	56	1	1	NUM
bam-5830	391	57	,	,	PUNCT
bam-5830	391	58	f.	f.	PROPN
bam-5830	391	59	longhena	longhena	PROPN
bam-5830	391	60	1	1	NUM
bam-5830	391	61	,	,	PUNCT
bam-5830	391	62	e.	e.	PROPN
bam-5830	391	63	monti	monti	PROPN
bam-5830	391	64	2	2	PROPN
bam-5830	391	65	,	,	PUNCT
bam-5830	391	66	b.	b.	PROPN
bam-5830	391	67	salani	salani	PROPN
bam-5830	391	68	3	3	NUM
bam-5830	391	69	,	,	PUNCT
bam-5830	391	70	d.	d.	PROPN
bam-5830	391	71	maggi	maggi	PROPN
bam-5830	391	72	3	3	NUM
bam-5830	391	73	,	,	PUNCT
bam-5830	391	74	c.	c.	PROPN
bam-5830	391	75	keller	keller	PROPN
bam-5830	391	76	4	4	NUM
bam-5830	391	77	,	,	PUNCT
bam-5830	391	78	a.	a.	NOUN
bam-5830	391	79	fanzani	fanzani	PROPN
bam-5830	391	80	1,2	1,2	NUM
bam-5830	391	81	1	1	NUM
bam-5830	391	82	.	.	PUNCT
bam-5830	392	1	department	department	NOUN
bam-5830	392	2	of	of	ADP
bam-5830	392	3	molecular	molecular	ADJ
bam-5830	392	4	and	and	CCONJ
bam-5830	392	5	translational	translational	ADJ
bam-5830	392	6	medicine	medicine	NOUN
bam-5830	392	7	and	and	CCONJ
bam-5830	392	8	interuniversity	interuniversity	NOUN
bam-5830	392	9	institute	institute	PROPN
bam-5830	392	10	of	of	ADP
bam-5830	392	11	myology	myology	NOUN
bam-5830	392	12	(	(	PUNCT
bam-5830	392	13	iim	iim	NOUN
bam-5830	392	14	)	)	PUNCT
bam-5830	392	15	,	,	PUNCT
bam-5830	392	16	university	university	NOUN
bam-5830	392	17	of	of	ADP
bam-5830	392	18	brescia	brescia	PROPN
bam-5830	392	19	,	,	PUNCT
bam-5830	392	20	italy	italy	PROPN
bam-5830	392	21	;	;	PUNCT
bam-5830	392	22	2	2	X
bam-5830	392	23	.	.	X
bam-5830	392	24	unit	unit	NOUN
bam-5830	392	25	of	of	ADP
bam-5830	392	26	histology	histology	NOUN
bam-5830	392	27	and	and	CCONJ
bam-5830	392	28	iim	iim	PROPN
bam-5830	392	29	,	,	PUNCT
bam-5830	392	30	sapienza	sapienza	PROPN
bam-5830	392	31	university	university	PROPN
bam-5830	392	32	,	,	PUNCT
bam-5830	392	33	dahfmo	dahfmo	PROPN
bam-5830	392	34	,	,	PUNCT
bam-5830	392	35	rome	rome	PROPN
bam-5830	392	36	,	,	PUNCT
bam-5830	392	37	italy	italy	PROPN
bam-5830	392	38	;	;	PUNCT
bam-5830	392	39	3	3	X
bam-5830	392	40	.	.	X
bam-5830	392	41	department	department	NOUN
bam-5830	392	42	of	of	ADP
bam-5830	392	43	endocrinology	endocrinology	NOUN
bam-5830	392	44	and	and	CCONJ
bam-5830	392	45	medicine	medicine	NOUN
bam-5830	392	46	,	,	PUNCT
bam-5830	392	47	university	university	PROPN
bam-5830	392	48	of	of	ADP
bam-5830	392	49	genoa	genoa	PROPN
bam-5830	392	50	,	,	PUNCT
bam-5830	392	51	italy	italy	PROPN
bam-5830	392	52	;	;	PUNCT
bam-5830	392	53	
 	
 	SPACE
bam-5830	392	54	4	4	X
bam-5830	392	55	.	.	PUNCT
bam-5830	392	56	department	department	NOUN
bam-5830	392	57	of	of	ADP
bam-5830	392	58	pediatrics	pediatric	NOUN
bam-5830	392	59	,	,	PUNCT
bam-5830	392	60	oregon	oregon	PROPN
bam-5830	392	61	health	health	PROPN
bam-5830	392	62	&	&	CCONJ
bam-5830	392	63	science	science	PROPN
bam-5830	392	64	university	university	PROPN
bam-5830	392	65	,	,	PUNCT
bam-5830	392	66	usa	usa	PROPN
bam-5830	392	67	e	e	PROPN
bam-5830	392	68	-	-	NOUN
bam-5830	392	69	mail	mail	NOUN
bam-5830	392	70	:	:	PUNCT
bam-5830	392	71	fiorella.faggi@med.unibs.it	fiorella.faggi@med.unibs.it	NUM
bam-5830	392	72	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-5830	392	73	(	(	PUNCT
bam-5830	392	74	rms	rm	NOUN
bam-5830	392	75	)	)	PUNCT
bam-5830	392	76	is	be	AUX
bam-5830	392	77	a	a	DET
bam-5830	392	78	childhood	childhood	NOUN
bam-5830	392	79	soft	soft	ADJ
bam-5830	392	80	tissue	tissue	NOUN
bam-5830	392	81	tumor	tumor	NOUN
bam-5830	392	82	with	with	ADP
bam-5830	392	83	broad	broad	ADJ
bam-5830	392	84	expression	expression	NOUN
bam-5830	392	85	of	of	ADP
bam-5830	392	86	markers	marker	NOUN
bam-5830	392	87	that	that	PRON
bam-5830	392	88	are	be	AUX
bam-5830	392	89	typically	typically	ADV
bam-5830	392	90	found	find	VERB
bam-5830	392	91	in	in	ADP
bam-5830	392	92	skeletal	skeletal	ADJ
bam-5830	392	93	muscle	muscle	NOUN
bam-5830	392	94	.	.	PUNCT
bam-5830	393	1	cavin-1	cavin-1	NUM
bam-5830	393	2	is	be	AUX
bam-5830	393	3	a	a	DET
bam-5830	393	4	recently	recently	ADV
bam-5830	393	5	discovered	discover	VERB
bam-5830	393	6	protein	protein	NOUN
bam-5830	393	7	actively	actively	ADV
bam-5830	393	8	cooperating	cooperate	VERB
bam-5830	393	9	with	with	ADP
bam-5830	393	10	caveolin-1	caveolin-1	NUM
bam-5830	393	11	(	(	PUNCT
bam-5830	393	12	cav-1	cav-1	X
bam-5830	393	13	)	)	PUNCT
bam-5830	393	14	in	in	ADP
bam-5830	393	15	the	the	DET
bam-5830	393	16	morphogenesis	morphogenesis	NOUN
bam-5830	393	17	of	of	ADP
bam-5830	393	18	caveolae	caveolae	NOUN
bam-5830	393	19	and	and	CCONJ
bam-5830	393	20	whose	whose	DET
bam-5830	393	21	role	role	NOUN
bam-5830	393	22	in	in	ADP
bam-5830	393	23	cancer	cancer	NOUN
bam-5830	393	24	is	be	AUX
bam-5830	393	25	drawing	draw	VERB
bam-5830	393	26	increasing	increase	VERB
bam-5830	393	27	attention	attention	NOUN
bam-5830	393	28	.	.	PUNCT
bam-5830	394	1	using	use	VERB
bam-5830	394	2	a	a	DET
bam-5830	394	3	combined	combine	VERB
bam-5830	394	4	in	in	ADP
bam-5830	394	5	silico	silico	NOUN
bam-5830	394	6	and	and	CCONJ
bam-5830	394	7	in	in	ADP
bam-5830	394	8	vitro	vitro	X
bam-5830	394	9	analysis	analysis	NOUN
bam-5830	394	10	here	here	ADV
bam-5830	394	11	we	we	PRON
bam-5830	394	12	show	show	VERB
bam-5830	394	13	that	that	SCONJ
bam-5830	394	14	cavin-1	cavin-1	NUM
bam-5830	394	15	is	be	AUX
bam-5830	394	16	expressed	express	VERB
bam-5830	394	17	in	in	ADP
bam-5830	394	18	myogenic	myogenic	ADJ
bam-5830	394	19	rms	rm	NOUN
bam-5830	394	20	tumors	tumor	NOUN
bam-5830	394	21	as	as	ADV
bam-5830	394	22	well	well	ADV
bam-5830	394	23	as	as	ADP
bam-5830	394	24	in	in	ADP
bam-5830	394	25	human	human	ADJ
bam-5830	394	26	and	and	CCONJ
bam-5830	394	27	primary	primary	ADJ
bam-5830	394	28	mouse	mouse	NOUN
bam-5830	394	29	rms	rm	NOUN
bam-5830	394	30	cultures	culture	NOUN
bam-5830	394	31	,	,	PUNCT
bam-5830	394	32	exhibiting	exhibit	VERB
bam-5830	394	33	a	a	DET
bam-5830	394	34	broad	broad	ADJ
bam-5830	394	35	subcellular	subcellular	ADJ
bam-5830	394	36	localization	localization	NOUN
bam-5830	394	37	,	,	PUNCT
bam-5830	394	38	ranging	range	VERB
bam-5830	394	39	from	from	ADP
bam-5830	394	40	nuclei	nucleus	NOUN
bam-5830	394	41	and	and	CCONJ
bam-5830	394	42	cytosol	cytosol	NOUN
bam-5830	394	43	to	to	ADP
bam-5830	394	44	plasma	plasma	NOUN
bam-5830	394	45	membrane	membrane	NOUN
bam-5830	394	46	.	.	PUNCT
bam-5830	395	1	in	in	ADP
bam-5830	395	2	particular	particular	ADJ
bam-5830	395	3	,	,	PUNCT
bam-5830	395	4	the	the	DET
bam-5830	395	5	coexpression	coexpression	NOUN
bam-5830	395	6	and	and	CCONJ
bam-5830	395	7	plasma	plasma	NOUN
bam-5830	395	8	membrane	membrane	NOUN
bam-5830	395	9	interaction	interaction	NOUN
bam-5830	395	10	between	between	ADP
bam-5830	395	11	cavin-1	cavin-1	NUM
bam-5830	395	12	and	and	CCONJ
bam-5830	395	13	cav-1	cav-1	PUNCT
bam-5830	395	14	characterized	characterize	VERB
bam-5830	395	15	the	the	DET
bam-5830	395	16	proliferation	proliferation	NOUN
bam-5830	395	17	of	of	ADP
bam-5830	395	18	human	human	ADJ
bam-5830	395	19	and	and	CCONJ
bam-5830	395	20	mouse	mouse	PROPN
bam-5830	395	21	rms	rm	NOUN
bam-5830	395	22	cell	cell	NOUN
bam-5830	395	23	cultures	culture	NOUN
bam-5830	395	24	,	,	PUNCT
bam-5830	395	25	while	while	SCONJ
bam-5830	395	26	a	a	DET
bam-5830	395	27	downregulation	downregulation	NOUN
bam-5830	395	28	of	of	ADP
bam-5830	395	29	their	their	PRON
bam-5830	395	30	expression	expression	NOUN
bam-5830	395	31	levels	level	NOUN
bam-5830	395	32	was	be	AUX
bam-5830	395	33	observed	observe	VERB
bam-5830	395	34	during	during	ADP
bam-5830	395	35	the	the	DET
bam-5830	395	36	myogenic	myogenic	ADJ
bam-5830	395	37	differentiation	differentiation	NOUN
bam-5830	395	38	.	.	PUNCT
bam-5830	396	1	knockdown	knockdown	NOUN
bam-5830	396	2	of	of	ADP
bam-5830	396	3	cavin-1	cavin-1	NUM
bam-5830	396	4	or	or	CCONJ
bam-5830	396	5	cav-1	cav-1	PUNCT
bam-5830	396	6	in	in	ADP
bam-5830	396	7	the	the	DET
bam-5830	396	8	human	human	PROPN
bam-5830	396	9	rd	rd	PROPN
bam-5830	396	10	and	and	CCONJ
bam-5830	396	11	rh30	rh30	PROPN
bam-5830	396	12	cells	cell	NOUN
bam-5830	396	13	led	lead	VERB
bam-5830	396	14	to	to	ADP
bam-5830	396	15	impairment	impairment	NOUN
bam-5830	396	16	of	of	ADP
bam-5830	396	17	cell	cell	NOUN
bam-5830	396	18	proliferation	proliferation	NOUN
bam-5830	396	19	and	and	CCONJ
bam-5830	396	20	migration	migration	NOUN
bam-5830	396	21	.	.	PUNCT
bam-5830	397	1	moreover	moreover	ADV
bam-5830	397	2	,	,	PUNCT
bam-5830	397	3	loss	loss	NOUN
bam-5830	397	4	of	of	ADP
bam-5830	397	5	cavin-1	cavin-1	NUM
bam-5830	397	6	in	in	ADP
bam-5830	397	7	rd	rd	NOUN
bam-5830	397	8	cells	cell	NOUN
bam-5830	397	9	impaired	impair	VERB
bam-5830	397	10	the	the	DET
bam-5830	397	11	anchorage	anchorage	NOUN
bam-5830	397	12	-	-	PUNCT
bam-5830	397	13	independent	independent	ADJ
bam-5830	397	14	cell	cell	NOUN
bam-5830	397	15	growth	growth	NOUN
bam-5830	397	16	in	in	ADP
bam-5830	397	17	soft	soft	ADJ
bam-5830	397	18	agar	agar	NOUN
bam-5830	397	19	.	.	PUNCT
bam-5830	398	1	while	while	SCONJ
bam-5830	398	2	the	the	DET
bam-5830	398	3	loss	loss	NOUN
bam-5830	398	4	of	of	ADP
bam-5830	398	5	cavin-1	cavin-1	NUM
bam-5830	398	6	did	do	AUX
bam-5830	398	7	not	not	PART
bam-5830	398	8	affect	affect	VERB
bam-5830	398	9	the	the	DET
bam-5830	398	10	cav-1	cav-1	VERB
bam-5830	398	11	protein	protein	NOUN
bam-5830	398	12	levels	level	NOUN
bam-5830	398	13	in	in	ADP
bam-5830	398	14	rms	rm	NOUN
bam-5830	398	15	cells	cell	NOUN
bam-5830	398	16	,	,	PUNCT
bam-5830	398	17	cav-1	cav-1	NOUN
bam-5830	398	18	overexpression	overexpression	NOUN
bam-5830	398	19	and	and	CCONJ
bam-5830	398	20	knockdown	knockdown	NOUN
bam-5830	398	21	triggered	trigger	VERB
bam-5830	398	22	a	a	DET
bam-5830	398	23	rise	rise	NOUN
bam-5830	398	24	or	or	CCONJ
bam-5830	398	25	depletion	depletion	NOUN
bam-5830	398	26	of	of	ADP
bam-5830	398	27	cavin-1	cavin-1	NUM
bam-5830	398	28	protein	protein	NOUN
bam-5830	398	29	levels	level	NOUN
bam-5830	398	30	in	in	ADP
bam-5830	398	31	rd	rd	NOUN
bam-5830	398	32	cells	cell	NOUN
bam-5830	398	33	,	,	PUNCT
bam-5830	398	34	respectively	respectively	ADV
bam-5830	398	35	,	,	PUNCT
bam-5830	398	36	in	in	ADP
bam-5830	398	37	turn	turn	NOUN
bam-5830	398	38	reflecting	reflect	VERB
bam-5830	398	39	on	on	ADP
bam-5830	398	40	increased	increase	VERB
bam-5830	398	41	or	or	CCONJ
bam-5830	398	42	decreased	decrease	VERB
bam-5830	398	43	cell	cell	NOUN
bam-5830	398	44	proliferation	proliferation	NOUN
bam-5830	398	45	,	,	PUNCT
bam-5830	398	46	migration	migration	NOUN
bam-5830	398	47	and	and	CCONJ
bam-5830	398	48	anchorage	anchorage	NOUN
bam-5830	398	49	-	-	PUNCT
bam-5830	398	50	independent	independent	ADJ
bam-5830	398	51	cell	cell	NOUN
bam-5830	398	52	growth	growth	NOUN
bam-5830	398	53	.	.	PUNCT
bam-5830	399	1	collectively	collectively	ADV
bam-5830	399	2	,	,	PUNCT
bam-5830	399	3	these	these	DET
bam-5830	399	4	data	datum	NOUN
bam-5830	399	5	indicate	indicate	VERB
bam-5830	399	6	that	that	SCONJ
bam-5830	399	7	the	the	DET
bam-5830	399	8	interaction	interaction	NOUN
bam-5830	399	9	between	between	ADP
bam-5830	399	10	cavin-1	cavin-1	NUM
bam-5830	399	11	and	and	CCONJ
bam-5830	399	12	cav-1	cav-1	X
bam-5830	399	13	underlies	underlie	VERB
bam-5830	399	14	the	the	DET
bam-5830	399	15	cell	cell	NOUN
bam-5830	399	16	growth	growth	NOUN
bam-5830	399	17	,	,	PUNCT
bam-5830	399	18	migration	migration	NOUN
bam-5830	399	19	and	and	CCONJ
bam-5830	399	20	differentiation	differentiation	NOUN
bam-5830	399	21	grade	grade	NOUN
bam-5830	399	22	in	in	ADP
bam-5830	399	23	myogenic	myogenic	ADJ
bam-5830	399	24	tumors	tumor	NOUN
bam-5830	399	25	.	.	PUNCT
bam-5830	400	1	*	*	PUNCT
bam-5830	400	2	*	*	PUNCT
bam-5830	400	3	*	*	PUNCT
bam-5830	400	4	*	*	PUNCT
bam-5830	400	5	*	*	PUNCT
bam-5830	400	6	*	*	PUNCT
bam-5830	400	7	*	*	PUNCT
bam-5830	400	8	*	*	PUNCT
bam-5830	400	9	*	*	PUNCT
bam-5830	400	10	*	*	PUNCT
bam-5830	400	11	*	*	PUNCT
bam-5830	400	12	*	*	PUNCT
bam-5830	400	13	*	*	PUNCT
bam-5830	400	14	*	*	PUNCT
bam-5830	400	15	*	*	PUNCT
bam-5830	400	16	session	session	NOUN
bam-5830	400	17	5	5	NUM
bam-5830	400	18	.	.	PUNCT
bam-5830	400	19	signalling	signal	VERB
bam-5830	400	20	in	in	ADP
bam-5830	400	21	muscle	muscle	NOUN
bam-5830	400	22	homeostasis	homeostasis	NOUN
bam-5830	400	23	and	and	CCONJ
bam-5830	400	24	diseases	disease	NOUN
bam-5830	400	25	mitochondrial	mitochondrial	ADJ
bam-5830	400	26	protein	protein	NOUN
bam-5830	400	27	import	import	NOUN
bam-5830	400	28	is	be	AUX
bam-5830	400	29	regulated	regulate	VERB
bam-5830	400	30	by	by	ADP
bam-5830	400	31	ck2dependent	ck2dependent	NOUN
bam-5830	400	32	phosphorylation	phosphorylation	NOUN
bam-5830	400	33	of	of	ADP
bam-5830	400	34	outer	outer	ADJ
bam-5830	400	35	mitochondrial	mitochondrial	ADJ
bam-5830	400	36	membrane	membrane	NOUN
bam-5830	400	37	protein	protein	NOUN
bam-5830	400	38	tom22	tom22	PROPN
bam-5830	400	39	in	in	ADP
bam-5830	400	40	mouse	mouse	NOUN
bam-5830	400	41	skeletal	skeletal	ADJ
bam-5830	400	42	muscles	muscle	NOUN
bam-5830	400	43	b.	b.	PROPN
bam-5830	400	44	kravic	kravic	PROPN
bam-5830	400	45	1	1	NUM
bam-5830	400	46	,	,	PUNCT
bam-5830	400	47	a.	a.	PROPN
bam-5830	400	48	b.	b.	PROPN
bam-5830	400	49	harbauer	harbauer	PROPN
bam-5830	400	50	2	2	NUM
bam-5830	400	51	,	,	PUNCT
bam-5830	400	52	l.	l.	PROPN
bam-5830	400	53	simeone	simeone	PROPN
bam-5830	400	54	1	1	NUM
bam-5830	400	55	,	,	PUNCT
bam-5830	400	56	t.	t.	PROPN
bam-5830	400	57	kaiser	kaiser	PROPN
bam-5830	400	58	1	1	NUM
bam-5830	400	59	,	,	PUNCT
bam-5830	400	60	v.	v.	CCONJ
bam-5830	400	61	romanello	romanello	ADJ
bam-5830	400	62	3	3	NUM
bam-5830	400	63	,	,	PUNCT
bam-5830	400	64	a.	a.	NOUN
bam-5830	400	65	buttgereit	buttgereit	NOUN
bam-5830	400	66	4	4	NUM
bam-5830	400	67	,	,	PUNCT
bam-5830	400	68	w.	w.	PROPN
bam-5830	400	69	neuhuber	neuhuber	PROPN
bam-5830	400	70	5	5	NUM
bam-5830	400	71	,	,	PUNCT
bam-5830	400	72	m.	m.	NOUN
bam-5830	400	73	straubinger	straubinger	NOUN
bam-5830	400	74	1	1	NUM
bam-5830	400	75	,	,	PUNCT
bam-5830	400	76	d.	d.	PROPN
bam-5830	400	77	heuss	heus	VERB
bam-5830	400	78	6	6	NUM
bam-5830	400	79	,	,	PUNCT
bam-5830	400	80	r.	r.	PROPN
bam-5830	400	81	rudolf	rudolf	PROPN
bam-5830	400	82	7	7	NUM
bam-5830	400	83	,	,	PUNCT
bam-5830	400	84	o.	o.	NOUN
bam-5830	400	85	friedrich	friedrich	PROPN
bam-5830	400	86	4	4	NUM
bam-5830	400	87	,	,	PUNCT
bam-5830	400	88	m.	m.	NOUN
bam-5830	400	89	sandri	sandri	NOUN
bam-5830	400	90	3	3	NUM
bam-5830	400	91	,	,	PUNCT
bam-5830	400	92	c.	c.	NOUN
bam-5830	400	93	meisinger	meisinger	NOUN
bam-5830	400	94	2	2	NUM
bam-5830	400	95	,	,	PUNCT
bam-5830	400	96	s.	s.	PROPN
bam-5830	400	97	hashemolhosseini	hashemolhosseini	PROPN
bam-5830	400	98	1	1	NUM
bam-5830	400	99	1	1	NUM
bam-5830	400	100	.	.	PUNCT
bam-5830	401	1	institut	institut	PROPN
bam-5830	401	2	für	für	PROPN
bam-5830	401	3	biochemie	biochemie	PROPN
bam-5830	401	4	,	,	PUNCT
bam-5830	401	5	friedrich	friedrich	NOUN
bam-5830	401	6	-	-	PUNCT
bam-5830	401	7	alexander	alexander	NOUN
bam-5830	401	8	-	-	PUNCT
bam-5830	401	9	universität	universität	ADJ
bam-5830	401	10	erlangen	erlangen	PROPN
bam-5830	401	11	-	-	PUNCT
bam-5830	401	12	nürnberg	nürnberg	PROPN
bam-5830	401	13	,	,	PUNCT
bam-5830	401	14	erlangen	erlangen	PROPN
bam-5830	401	15	,	,	PUNCT
bam-5830	401	16	germany	germany	PROPN
bam-5830	401	17	;	;	PUNCT
bam-5830	401	18	2	2	X
bam-5830	401	19	.	.	X
bam-5830	401	20	institut	institut	PROPN
bam-5830	401	21	für	für	PROPN
bam-5830	401	22	biochemie	biochemie	VERB
bam-5830	401	23	und	und	PROPN
bam-5830	401	24	molekularbiologie	molekularbiologie	NOUN
bam-5830	401	25	,	,	PUNCT
bam-5830	401	26	zbmz	zbmz	NOUN
bam-5830	401	27	,	,	PUNCT
bam-5830	401	28	universität	universität	PROPN
bam-5830	401	29	freiburg	freiburg	PROPN
bam-5830	401	30	,	,	PUNCT
bam-5830	401	31	germany	germany	PROPN
bam-5830	401	32	;	;	PUNCT
bam-5830	401	33	3	3	X
bam-5830	401	34	.	.	X
bam-5830	401	35	dulbecco	dulbecco	PROPN
bam-5830	401	36	telethon	telethon	PROPN
bam-5830	401	37	institute	institute	NOUN
bam-5830	401	38	at	at	ADP
bam-5830	401	39	venetian	venetian	PROPN
bam-5830	401	40	institute	institute	NOUN
bam-5830	401	41	of	of	ADP
bam-5830	401	42	molecular	molecular	ADJ
bam-5830	401	43	medicine	medicine	NOUN
bam-5830	401	44	,	,	PUNCT
bam-5830	401	45	padova	padova	PROPN
bam-5830	401	46	,	,	PUNCT
bam-5830	401	47	italy	italy	PROPN
bam-5830	401	48	;	;	PUNCT
bam-5830	401	49	4	4	NUM
bam-5830	401	50	medizinische	medizinische	PROPN
bam-5830	401	51	biotechnologie	biotechnologie	PROPN
bam-5830	401	52	,	,	PUNCT
bam-5830	401	53	friedrich	friedrich	ADJ
bam-5830	401	54	-	-	PUNCT
bam-5830	401	55	alexanderuniversität	alexanderuniversität	NOUN
bam-5830	401	56	erlangen	erlangen	PROPN
bam-5830	401	57	-	-	PUNCT
bam-5830	401	58	nürnberg	nürnberg	PROPN
bam-5830	401	59	,	,	PUNCT
bam-5830	401	60	germany	germany	PROPN
bam-5830	401	61	;	;	PUNCT
bam-5830	401	62	5	5	X
bam-5830	401	63	.	.	NOUN
bam-5830	402	1	anatomisches	anatomisches	PROPN
bam-5830	402	2	institut	institut	PROPN
bam-5830	402	3	,	,	PUNCT
bam-5830	402	4	friedrich	friedrich	PROPN
bam-5830	402	5	-	-	PUNCT
bam-5830	402	6	alexander	alexander	NOUN
bam-5830	402	7	-	-	PUNCT
bam-5830	402	8	universität	universität	ADJ
bam-5830	402	9	erlangen	erlangen	PROPN
bam-5830	402	10	-	-	PUNCT
bam-5830	402	11	nürnberg	nürnberg	PROPN
bam-5830	402	12	,	,	PUNCT
bam-5830	402	13	germany	germany	PROPN
bam-5830	402	14	;	;	PUNCT
bam-5830	402	15	6	6	X
bam-5830	402	16	.	.	X
bam-5830	402	17	neurologische	neurologische	PROPN
bam-5830	402	18	klinik	klinik	PROPN
bam-5830	402	19	,	,	PUNCT
bam-5830	402	20	friedrich	friedrich	PROPN
bam-5830	402	21	-	-	PUNCT
bam-5830	402	22	alexanderuniversität	alexanderuniversität	NOUN
bam-5830	402	23	erlangen	erlangen	PROPN
bam-5830	402	24	-	-	PUNCT
bam-5830	402	25	nürnberg	nürnberg	PROPN
bam-5830	402	26	,	,	PUNCT
bam-5830	402	27	germany	germany	PROPN
bam-5830	402	28	;	;	PUNCT
bam-5830	402	29	7	7	X
bam-5830	402	30	.	.	X
bam-5830	402	31	university	university	NOUN
bam-5830	402	32	of	of	ADP
bam-5830	402	33	applied	apply	VERB
bam-5830	402	34	sciences	sciences	PROPN
bam-5830	402	35	mannheim	mannheim	PROPN
bam-5830	402	36	,	,	PUNCT
bam-5830	402	37	germany	germany	PROPN
bam-5830	402	38	e	e	PROPN
bam-5830	402	39	-	-	NOUN
bam-5830	402	40	mail	mail	NOUN
bam-5830	402	41	:	:	PUNCT
bam-5830	402	42	said.hashemolhosseini@fau.de	said.hashemolhosseini@fau.de	NOUN
bam-5830	402	43	recently	recently	ADV
bam-5830	402	44	,	,	PUNCT
bam-5830	402	45	it	it	PRON
bam-5830	402	46	was	be	AUX
bam-5830	402	47	shown	show	VERB
bam-5830	402	48	that	that	SCONJ
bam-5830	402	49	in	in	ADP
bam-5830	402	50	yeast	yeast	NOUN
bam-5830	402	51	ck2	ck2	NOUN
bam-5830	402	52	-	-	PUNCT
bam-5830	402	53	dependent	dependent	ADJ
bam-5830	402	54	phosphorylation	phosphorylation	NOUN
bam-5830	402	55	of	of	ADP
bam-5830	402	56	the	the	DET
bam-5830	402	57	mitochondrial	mitochondrial	ADJ
bam-5830	402	58	import	import	NOUN
bam-5830	402	59	receptor	receptor	NOUN
bam-5830	402	60	tom22	tom22	PROPN
bam-5830	402	61	promotes	promote	VERB
bam-5830	402	62	biogenesis	biogenesis	NOUN
bam-5830	402	63	of	of	ADP
bam-5830	402	64	the	the	DET
bam-5830	402	65	tom	tom	PROPN
bam-5830	402	66	translocase	translocase	NOUN
bam-5830	402	67	and	and	CCONJ
bam-5830	402	68	is	be	AUX
bam-5830	402	69	required	require	VERB
bam-5830	402	70	for	for	ADP
bam-5830	402	71	import	import	NOUN
bam-5830	402	72	of	of	ADP
bam-5830	402	73	mitochondrial	mitochondrial	ADJ
bam-5830	402	74	proteins	protein	NOUN
bam-5830	402	75	.	.	PUNCT
bam-5830	403	1	we	we	PRON
bam-5830	403	2	asked	ask	VERB
bam-5830	403	3	whether	whether	SCONJ
bam-5830	403	4	ck2	ck2	NOUN
bam-5830	403	5	-	-	PUNCT
bam-5830	403	6	dependent	dependent	ADJ
bam-5830	403	7	phosphorylation	phosphorylation	NOUN
bam-5830	403	8	of	of	ADP
bam-5830	403	9	tom	tom	PROPN
bam-5830	403	10	proteins	protein	NOUN
bam-5830	403	11	also	also	ADV
bam-5830	403	12	occurs	occur	VERB
bam-5830	403	13	in	in	ADP
bam-5830	403	14	mammals	mammal	NOUN
bam-5830	403	15	.	.	PUNCT
bam-5830	404	1	using	use	VERB
bam-5830	404	2	ck2-deficient	ck2-deficient	NOUN
bam-5830	404	3	skeletal	skeletal	ADJ
bam-5830	404	4	muscle	muscle	NOUN
bam-5830	404	5	lysates	lysate	NOUN
bam-5830	404	6	,	,	PUNCT
bam-5830	404	7	we	we	PRON
bam-5830	404	8	observed	observe	VERB
bam-5830	404	9	less	less	ADJ
bam-5830	404	10	phosphorylation	phosphorylation	NOUN
bam-5830	404	11	of	of	ADP
bam-5830	404	12	tom22	tom22	PROPN
bam-5830	404	13	.	.	PUNCT
bam-5830	405	1	moreover	moreover	ADV
bam-5830	405	2	,	,	PUNCT
bam-5830	405	3	we	we	PRON
bam-5830	405	4	confirmed	confirm	VERB
bam-5830	405	5	ck2	ck2	NOUN
bam-5830	405	6	phosphorylating	phosphorylating	NOUN
bam-5830	405	7	residues	residue	NOUN
bam-5830	405	8	serine	serine	VERB
bam-5830	405	9	15	15	NUM
bam-5830	405	10	and	and	CCONJ
bam-5830	405	11	threonine	threonine	ADJ
bam-5830	405	12	43	43	NUM
bam-5830	405	13	of	of	ADP
bam-5830	405	14	murine	murine	PROPN
bam-5830	405	15	tom22	tom22	PROPN
bam-5830	405	16	.	.	PUNCT
bam-5830	406	1	further	far	ADV
bam-5830	406	2	,	,	PUNCT
bam-5830	406	3	ck2dependent	ck2dependent	PRON
bam-5830	406	4	phosphorylation	phosphorylation	NOUN
bam-5830	406	5	of	of	ADP
bam-5830	406	6	tom22	tom22	PROPN
bam-5830	406	7	changes	change	VERB
bam-5830	406	8	its	its	PRON
bam-5830	406	9	binding	bind	VERB
bam-5830	406	10	affinity	affinity	NOUN
bam-5830	406	11	for	for	ADP
bam-5830	406	12	proteins	protein	NOUN
bam-5830	406	13	need	need	VERB
bam-5830	406	14	to	to	PART
bam-5830	406	15	be	be	AUX
bam-5830	406	16	imported	import	VERB
bam-5830	406	17	into	into	ADP
bam-5830	406	18	mitochondria	mitochondria	NOUN
bam-5830	406	19	.	.	PUNCT
bam-5830	407	1	in	in	ADP
bam-5830	407	2	the	the	DET
bam-5830	407	3	absence	absence	NOUN
bam-5830	407	4	of	of	ADP
bam-5830	407	5	ck2	ck2	NOUN
bam-5830	407	6	mitochondrial	mitochondrial	ADJ
bam-5830	407	7	protein	protein	NOUN
bam-5830	407	8	import	import	NOUN
bam-5830	407	9	is	be	AUX
bam-5830	407	10	impaired	impair	VERB
bam-5830	407	11	in	in	ADP
bam-5830	407	12	muscle	muscle	NOUN
bam-5830	407	13	fibers	fiber	NOUN
bam-5830	407	14	and	and	CCONJ
bam-5830	407	15	mitochondria	mitochondria	NOUN
bam-5830	407	16	are	be	AUX
bam-5830	407	17	dysfunctional	dysfunctional	ADJ
bam-5830	407	18	.	.	PUNCT
bam-5830	408	1	pink1	pink1	NOUN
bam-5830	408	2	,	,	PUNCT
bam-5830	408	3	a	a	DET
bam-5830	408	4	mitochondria	mitochondria	PROPN
bam-5830	408	5	health	health	NOUN
bam-5830	408	6	sensor	sensor	NOUN
bam-5830	408	7	and	and	CCONJ
bam-5830	408	8	involved	involve	VERB
bam-5830	408	9	in	in	ADP
bam-5830	408	10	parkinson	parkinson	NOUN
bam-5830	408	11	s	s	PART
bam-5830	408	12	disease	disease	NOUN
bam-5830	408	13	,	,	PUNCT
bam-5830	408	14	accumulates	accumulate	VERB
bam-5830	408	15	within	within	ADP
bam-5830	408	16	mutant	mutant	ADJ
bam-5830	408	17	muscle	muscle	NOUN
bam-5830	408	18	cells	cell	NOUN
bam-5830	408	19	,	,	PUNCT
bam-5830	408	20	and	and	CCONJ
bam-5830	408	21	labels	label	VERB
bam-5830	408	22	removal	removal	NOUN
bam-5830	408	23	of	of	ADP
bam-5830	408	24	dysfunctional	dysfunctional	ADJ
bam-5830	408	25	mitochondria	mitochondria	NOUN
bam-5830	408	26	by	by	ADP
bam-5830	408	27	mitophagy	mitophagy	NOUN
bam-5830	408	28	and	and	CCONJ
bam-5830	408	29	involvement	involvement	NOUN
bam-5830	408	30	of	of	ADP
bam-5830	408	31	autophagic	autophagic	ADJ
bam-5830	408	32	adaptor	adaptor	NOUN
bam-5830	408	33	protein	protein	NOUN
bam-5830	408	34	p62	p62	NOUN
bam-5830	408	35	/	/	SYM
bam-5830	408	36	sqstm1	sqstm1	NOUN
bam-5830	408	37	.	.	PUNCT
bam-5830	409	1	consequently	consequently	ADV
bam-5830	409	2	,	,	PUNCT
bam-5830	409	3	the	the	DET
bam-5830	409	4	metabolism	metabolism	NOUN
bam-5830	409	5	of	of	ADP
bam-5830	409	6	oxidative	oxidative	ADJ
bam-5830	409	7	muscle	muscle	NOUN
bam-5830	409	8	fibers	fiber	NOUN
bam-5830	409	9	in	in	ADP
bam-5830	409	10	mutant	mutant	ADJ
bam-5830	409	11	muscles	muscle	NOUN
bam-5830	409	12	shifted	shift	VERB
bam-5830	409	13	towards	towards	ADP
bam-5830	409	14	glycolytic	glycolytic	NOUN
bam-5830	409	15	.	.	PUNCT
bam-5830	410	1	as	as	ADP
bam-5830	410	2	proof	proof	NOUN
bam-5830	410	3	of	of	ADP
bam-5830	410	4	concept	concept	NOUN
bam-5830	410	5	,	,	PUNCT
bam-5830	410	6	removal	removal	NOUN
bam-5830	410	7	of	of	ADP
bam-5830	410	8	aggregated	aggregated	ADJ
bam-5830	410	9	p62	p62	NOUN
bam-5830	410	10	/	/	SYM
bam-5830	410	11	sqstm1	sqstm1	NOUN
bam-5830	410	12	by	by	ADP
bam-5830	410	13	muscular	muscular	ADJ
bam-5830	410	14	in	in	ADP
bam-5830	410	15	vivo	vivo	ADJ
bam-5830	410	16	electroporation	electroporation	NOUN
bam-5830	410	17	of	of	ADP
bam-5830	410	18	phosphomimetic	phosphomimetic	ADJ
bam-5830	410	19	tom22	tom22	PROPN
bam-5830	410	20	was	be	AUX
bam-5830	410	21	successful	successful	ADJ
bam-5830	410	22	.	.	PUNCT
bam-5830	411	1	this	this	PRON
bam-5830	411	2	is	be	AUX
bam-5830	411	3	the	the	DET
bam-5830	411	4	first	first	ADJ
bam-5830	411	5	evidence	evidence	NOUN
bam-5830	411	6	for	for	ADP
bam-5830	411	7	both	both	PRON
bam-5830	411	8	,	,	PUNCT
bam-5830	411	9	regulated	regulated	ADJ
bam-5830	411	10	protein	protein	NOUN
bam-5830	411	11	import	import	NOUN
bam-5830	411	12	into	into	ADP
bam-5830	411	13	mammalian	mammalian	ADJ
bam-5830	411	14	mitochondria	mitochondria	NOUN
bam-5830	411	15	,	,	PUNCT
bam-5830	411	16	and	and	CCONJ
bam-5830	411	17	muscle	muscle	NOUN
bam-5830	411	18	weaknes	weakne	NOUN
bam-5830	411	19	due	due	ADJ
bam-5830	411	20	to	to	ADP
bam-5830	411	21	a	a	DET
bam-5830	411	22	mitochondrial	mitochondrial	ADJ
bam-5830	411	23	protein	protein	NOUN
bam-5830	411	24	import	import	NOUN
bam-5830	411	25	defect	defect	NOUN
bam-5830	411	26	.	.	PUNCT
bam-5830	412	1	*	*	PUNCT
bam-5830	412	2	*	*	PUNCT
bam-5830	412	3	*	*	PUNCT
bam-5830	412	4	*	*	PUNCT
bam-5830	412	5	*	*	PUNCT
bam-5830	412	6	canonical	canonical	ADJ
bam-5830	412	7	wnt/-catenin	wnt/-catenin	NOUN
bam-5830	412	8	signaling	signal	VERB
bam-5830	412	9	through	through	ADP
bam-5830	412	10	axin2	axin2	NOUN
bam-5830	412	11	,	,	PUNCT
bam-5830	412	12	yap	yap	PROPN
bam-5830	412	13	/	/	SYM
bam-5830	412	14	taz	taz	PROPN
bam-5830	412	15	and	and	CCONJ
bam-5830	412	16	tead1	tead1	NOUN
bam-5830	412	17	,	,	PUNCT
bam-5830	412	18	is	be	AUX
bam-5830	412	19	essential	essential	ADJ
bam-5830	412	20	for	for	ADP
bam-5830	412	21	myotube	myotube	NOUN
bam-5830	412	22	formation	formation	NOUN
bam-5830	412	23	and	and	CCONJ
bam-5830	412	24	small	small	ADJ
bam-5830	412	25	diameter	diameter	NOUN
bam-5830	412	26	adult	adult	NOUN
bam-5830	412	27	fiber	fiber	NOUN
bam-5830	412	28	types	type	NOUN
bam-5830	412	29	d.	d.	PROPN
bam-5830	412	30	huraskin	huraskin	VERB
bam-5830	412	31	1	1	NUM
bam-5830	412	32	*	*	NOUN
bam-5830	412	33	,	,	PUNCT
bam-5830	412	34	n.	n.	NOUN
bam-5830	412	35	eiber	eiber	PROPN
bam-5830	412	36	1	1	NUM
bam-5830	412	37	*	*	NOUN
bam-5830	412	38	,	,	PUNCT
bam-5830	412	39	m.	m.	NOUN
bam-5830	412	40	reichel	reichel	PROPN
bam-5830	412	41	2	2	NUM
bam-5830	412	42	,	,	PUNCT
bam-5830	412	43	l.	l.	PROPN
bam-5830	412	44	zidek	zidek	PROPN
bam-5830	412	45	3	3	NUM
bam-5830	412	46	,	,	PUNCT
bam-5830	412	47	b.	b.	PROPN
bam-5830	412	48	kravic	kravic	PROPN
bam-5830	412	49	1	1	NUM
bam-5830	412	50	,	,	PUNCT
bam-5830	412	51	d.	d.	PROPN
bam-5830	412	52	bernkopf	bernkopf	VERB
bam-5830	412	53	2	2	NUM
bam-5830	412	54	,	,	PUNCT
bam-5830	412	55	j.	j.	PROPN
bam-5830	412	56	von	von	PROPN
bam-5830	412	57	maltzahn	maltzahn	PROPN
bam-5830	412	58	3	3	NUM
bam-5830	412	59	,	,	PUNCT
bam-5830	412	60	j.	j.	PROPN
bam-5830	412	61	behrens	behrens	PROPN
bam-5830	412	62	2	2	NUM
bam-5830	412	63	,	,	PUNCT
bam-5830	412	64	s.hashemolhosseini	s.hashemolhosseini	X
bam-5830	412	65	1	1	NUM
bam-5830	412	66	*	*	NOUN
bam-5830	412	67	these	these	DET
bam-5830	412	68	authors	author	NOUN
bam-5830	412	69	contributed	contribute	VERB
bam-5830	412	70	equally	equally	ADV
bam-5830	412	71	to	to	ADP
bam-5830	412	72	this	this	DET
bam-5830	412	73	work	work	NOUN
bam-5830	412	74	.	.	PUNCT
bam-5830	413	1	1	1	X
bam-5830	413	2	.	.	X
bam-5830	413	3	institute	institute	PROPN
bam-5830	413	4	of	of	ADP
bam-5830	413	5	biochemistry	biochemistry	PROPN
bam-5830	413	6	,	,	PUNCT
bam-5830	413	7	2	2	X
bam-5830	413	8	.	.	X
bam-5830	413	9	department	department	NOUN
bam-5830	413	10	of	of	ADP
bam-5830	413	11	experimental	experimental	PROPN
bam-5830	413	12	medicine	medicine	PROPN
bam-5830	413	13	ii	ii	PROPN
bam-5830	413	14	,	,	PUNCT
bam-5830	413	15	friedrich	friedrich	PROPN
bam-5830	413	16	-	-	PUNCT
bam-5830	413	17	alexander	alexander	PROPN
bam-5830	413	18	university	university	PROPN
bam-5830	413	19	erlangennürnberg	erlangennürnberg	PROPN
bam-5830	413	20	,	,	PUNCT
bam-5830	413	21	erlangen	erlangen	PROPN
bam-5830	413	22	,	,	PUNCT
bam-5830	413	23	germany	germany	PROPN
bam-5830	413	24	;	;	PUNCT
bam-5830	413	25	3	3	X
bam-5830	413	26	.	.	X
bam-5830	413	27	leibniz	leibniz	PROPN
bam-5830	413	28	institute	institute	PROPN
bam-5830	413	29	for	for	ADP
bam-5830	413	30	age	age	NOUN
bam-5830	413	31	research	research	PROPN
bam-5830	413	32	/	/	SYM
bam-5830	413	33	fritz	fritz	PROPN
bam-5830	413	34	lipmann	lipmann	PROPN
bam-5830	413	35	institute	institute	PROPN
bam-5830	413	36	(	(	PUNCT
bam-5830	413	37	fli	fli	PROPN
bam-5830	413	38	)	)	PUNCT
bam-5830	413	39	,	,	PUNCT
bam-5830	413	40	jena	jena	PROPN
bam-5830	413	41	;	;	PUNCT
bam-5830	413	42	germany	germany	PROPN
bam-5830	413	43	e	e	PROPN
bam-5830	413	44	-	-	NOUN
bam-5830	413	45	mail	mail	NOUN
bam-5830	413	46	:	:	PUNCT
bam-5830	413	47	danyil.huraskin@fau.de	danyil.huraskin@fau.de	VERB
bam-5830	413	48	canonical	canonical	ADJ
bam-5830	413	49	wnt/-catenin	wnt/-catenin	PROPN
bam-5830	414	1	signaling	signal	VERB
bam-5830	414	2	plays	play	VERB
bam-5830	414	3	a	a	DET
bam-5830	414	4	role	role	NOUN
bam-5830	414	5	in	in	ADP
bam-5830	414	6	myogenic	myogenic	ADJ
bam-5830	414	7	differentiation	differentiation	NOUN
bam-5830	414	8	,	,	PUNCT
bam-5830	414	9	but	but	CCONJ
bam-5830	414	10	its	its	PRON
bam-5830	414	11	role	role	NOUN
bam-5830	414	12	in	in	ADP
bam-5830	414	13	adult	adult	NOUN
bam-5830	414	14	muscle	muscle	NOUN
bam-5830	414	15	fibers	fiber	NOUN
bam-5830	414	16	is	be	AUX
bam-5830	414	17	completely	completely	ADV
bam-5830	414	18	unknown	unknown	ADJ
bam-5830	414	19	.	.	PUNCT
bam-5830	415	1	we	we	PRON
bam-5830	415	2	approached	approach	VERB
bam-5830	415	3	canonical	canonical	ADJ
bam-5830	415	4	wnt	wnt	NOUN
bam-5830	415	5	signaling	signal	VERB
bam-5830	415	6	in	in	ADP
bam-5830	415	7	adult	adult	NOUN
bam-5830	415	8	myofibers	myofiber	NOUN
bam-5830	415	9	by	by	ADP
bam-5830	415	10	well	well	ADV
bam-5830	415	11	-	-	PUNCT
bam-5830	415	12	known	know	VERB
bam-5830	415	13	reporter	reporter	NOUN
bam-5830	415	14	axin2lacz	axin2lacz	NOUN
bam-5830	415	15	mice	mouse	NOUN
bam-5830	415	16	,	,	PUNCT
bam-5830	415	17	monitoring	monitor	VERB
bam-5830	415	18	x	x	ADJ
bam-5830	415	19	-	-	ADJ
bam-5830	415	20	gal	gal	ADJ
bam-5830	415	21	staining	stain	VERB
bam-5830	415	22	in	in	ADP
bam-5830	415	23	muscle	muscle	NOUN
bam-5830	415	24	stem	stem	NOUN
bam-5830	415	25	cells	cell	NOUN
bam-5830	415	26	,	,	PUNCT
bam-5830	415	27	in	in	ADP
bam-5830	415	28	adult	adult	NOUN
bam-5830	415	29	muscle	muscle	NOUN
bam-5830	415	30	fibers	fiber	NOUN
bam-5830	415	31	and	and	CCONJ
bam-5830	415	32	at	at	ADP
bam-5830	415	33	their	their	PRON
bam-5830	415	34	neuromuscular	neuromuscular	ADJ
bam-5830	415	35	synapse	synapse	NOUN
bam-5830	415	36	.	.	PUNCT
bam-5830	416	1	in	in	ADP
bam-5830	416	2	muscle	muscle	NOUN
bam-5830	416	3	stem	stem	NOUN
bam-5830	416	4	cells	cell	NOUN
bam-5830	416	5	,	,	PUNCT
bam-5830	416	6	canonical	canonical	ADJ
bam-5830	416	7	wnt	wnt	NOUN
bam-5830	416	8	signalling	signal	VERB
bam-5830	416	9	is	be	AUX
bam-5830	416	10	absent	absent	ADJ
bam-5830	416	11	in	in	ADP
bam-5830	416	12	quiescent	quiescent	ADJ
bam-5830	416	13	cells	cell	NOUN
bam-5830	416	14	and	and	CCONJ
bam-5830	416	15	72	72	NUM
bam-5830	416	16	h	h	NOUN
bam-5830	416	17	proliferating	proliferate	VERB
bam-5830	416	18	cells	cell	NOUN
bam-5830	416	19	.	.	PUNCT
bam-5830	417	1	in	in	ADP
bam-5830	417	2	adult	adult	NOUN
bam-5830	417	3	muscle	muscle	NOUN
bam-5830	417	4	fibers	fiber	NOUN
bam-5830	417	5	,	,	PUNCT
bam-5830	417	6	canonical	canonical	ADJ
bam-5830	417	7	wnt	wnt	NOUN
bam-5830	417	8	signaling	signal	VERB
bam-5830	417	9	is	be	AUX
bam-5830	417	10	strongly	strongly	ADV
bam-5830	417	11	detectable	detectable	ADJ
bam-5830	417	12	by	by	ADP
bam-5830	417	13	axin2and	axin2and	PUNCT
bam-5830	418	1	-catenin	-catenin	PROPN
bam-5830	418	2	-	-	PUNCT
bam-5830	418	3	positive	positive	ADJ
bam-5830	418	4	skeletal	skeletal	ADJ
bam-5830	418	5	muscle	muscle	NOUN
bam-5830	418	6	fibers	fiber	NOUN
bam-5830	418	7	,	,	PUNCT
bam-5830	418	8	where	where	SCONJ
bam-5830	418	9	it	it	PRON
bam-5830	418	10	is	be	AUX
bam-5830	418	11	expressed	express	VERB
bam-5830	418	12	only	only	ADV
bam-5830	418	13	in	in	ADP
bam-5830	418	14	fast	fast	ADJ
bam-5830	418	15	fiber	fiber	NOUN
bam-5830	418	16	types	type	NOUN
bam-5830	418	17	with	with	ADP
bam-5830	418	18	small	small	ADJ
bam-5830	418	19	crosssectional	crosssectional	ADJ
bam-5830	418	20	areas	area	NOUN
bam-5830	418	21	.	.	PUNCT
bam-5830	419	1	in	in	ADP
bam-5830	419	2	these	these	DET
bam-5830	419	3	fibers	fiber	NOUN
bam-5830	419	4	,	,	PUNCT
bam-5830	419	5	canonical	canonical	ADJ
bam-5830	419	6	wnt	wnt	NOUN
bam-5830	419	7	signaling	signal	VERB
bam-5830	419	8	is	be	AUX
bam-5830	419	9	active	active	ADJ
bam-5830	419	10	together	together	ADV
bam-5830	419	11	with	with	ADP
bam-5830	419	12	hippo	hippo	ADJ
bam-5830	419	13	signaling	signal	VERB
bam-5830	419	14	members	member	NOUN
bam-5830	419	15	,	,	PUNCT
bam-5830	419	16	yap	yap	PROPN
bam-5830	419	17	/	/	SYM
bam-5830	419	18	taz	taz	PROPN
bam-5830	419	19	and	and	CCONJ
bam-5830	419	20	tead1	tead1	PROPN
bam-5830	419	21	.	.	PUNCT
bam-5830	420	1	during	during	ADP
bam-5830	420	2	differentiation	differentiation	NOUN
bam-5830	420	3	of	of	ADP
bam-5830	420	4	c2c12	c2c12	PROPN
bam-5830	420	5	cells	cell	NOUN
bam-5830	420	6	,	,	PUNCT
bam-5830	420	7	axin2	axin2	NOUN
bam-5830	420	8	increases	increase	VERB
bam-5830	420	9	together	together	ADV
bam-5830	420	10	with	with	ADP
bam-5830	420	11	the	the	DET
bam-5830	420	12	expression	expression	NOUN
bam-5830	420	13	of	of	ADP
bam-5830	420	14	tead1	tead1	NOUN
bam-5830	420	15	-	-	PUNCT
bam-5830	420	16	target	target	NOUN
bam-5830	420	17	genes	gene	NOUN
bam-5830	420	18	:	:	PUNCT
bam-5830	420	19	ctgf	ctgf	NOUN
bam-5830	420	20	,	,	PUNCT
bam-5830	420	21	ankrd1	ankrd1	NOUN
bam-5830	420	22	and	and	CCONJ
bam-5830	420	23	cyr61	cyr61	PROPN
bam-5830	420	24	.	.	PUNCT
bam-5830	421	1	in	in	ADP
bam-5830	421	2	cultured	cultured	ADJ
bam-5830	421	3	primary	primary	ADJ
bam-5830	421	4	muscle	muscle	NOUN
bam-5830	421	5	abstracts	abstract	NOUN
bam-5830	421	6	of	of	ADP
bam-5830	421	7	the	the	DET
bam-5830	421	8	xii	xii	PROPN
bam-5830	421	9	iim	iim	NOUN
bam-5830	421	10	myology	myology	NOUN
bam-5830	421	11	meeting	meeting	NOUN
bam-5830	421	12	october	october	PROPN
bam-5830	421	13	1–4	1–4	PROPN
bam-5830	421	14	,	,	PUNCT
bam-5830	421	15	2015	2015	NUM
bam-5830	421	16	eur	eur	PROPN
bam-5830	421	17	j	j	PROPN
bam-5830	421	18	transl	transl	PROPN
bam-5830	421	19	myol	myol	PROPN
bam-5830	421	20	basic	basic	ADJ
bam-5830	421	21	appl	appl	NOUN
bam-5830	421	22	myol	myol	NOUN
bam-5830	421	23	2016	2016	NUM
bam-5830	421	24	;	;	PUNCT
bam-5830	421	25	26	26	NUM
bam-5830	421	26	(	(	PUNCT
bam-5830	421	27	1):2	1):2	NUM
bam-5830	421	28	-	-	SYM
bam-5830	421	29	24	24	NUM
bam-5830	421	30	this	this	DET
bam-5830	421	31	article	article	NOUN
bam-5830	421	32	is	be	AUX
bam-5830	421	33	distributed	distribute	VERB
bam-5830	421	34	under	under	ADP
bam-5830	421	35	the	the	DET
bam-5830	421	36	terms	term	NOUN
bam-5830	421	37	of	of	ADP
bam-5830	421	38	the	the	DET
bam-5830	421	39	creative	creative	ADJ
bam-5830	421	40	commons	common	NOUN
bam-5830	421	41	attribution	attribution	NOUN
bam-5830	421	42	noncommercial	noncommercial	ADJ
bam-5830	421	43	license	license	NOUN
bam-5830	421	44	(	(	PUNCT
bam-5830	421	45	cc	cc	NOUN
bam-5830	421	46	by	by	ADP
bam-5830	421	47	-	-	PUNCT
bam-5830	421	48	nc	nc	PROPN
bam-5830	421	49	4.0	4.0	NUM
bam-5830	421	50	)	)	PUNCT
bam-5830	421	51	which	which	PRON
bam-5830	421	52	permits	permit	VERB
bam-5830	421	53	any	any	DET
bam-5830	421	54	noncommercial	noncommercial	ADJ
bam-5830	421	55	use	use	NOUN
bam-5830	421	56	,	,	PUNCT
bam-5830	421	57	distribution	distribution	NOUN
bam-5830	421	58	,	,	PUNCT
bam-5830	421	59	and	and	CCONJ
bam-5830	421	60	reproduction	reproduction	NOUN
bam-5830	421	61	in	in	ADP
bam-5830	421	62	any	any	DET
bam-5830	421	63	medium	medium	NOUN
bam-5830	421	64	,	,	PUNCT
bam-5830	421	65	provided	provide	VERB
bam-5830	421	66	the	the	DET
bam-5830	421	67	original	original	ADJ
bam-5830	421	68	author(s	author(s	NOUN
bam-5830	421	69	)	)	PUNCT
bam-5830	421	70	and	and	CCONJ
bam-5830	421	71	source	source	NOUN
bam-5830	421	72	are	be	AUX
bam-5830	421	73	credited	credit	VERB
bam-5830	421	74	.	.	PUNCT
bam-5830	422	1	14	14	NUM
bam-5830	422	2	cells	cell	NOUN
bam-5830	422	3	,	,	PUNCT
bam-5830	422	4	we	we	PRON
bam-5830	422	5	observed	observe	VERB
bam-5830	422	6	axin1	axin1	ADV
bam-5830	422	7	and	and	CCONJ
bam-5830	422	8	axin2	axin2	NOUN
bam-5830	422	9	being	be	AUX
bam-5830	422	10	involved	involve	VERB
bam-5830	422	11	in	in	ADP
bam-5830	422	12	proliferation	proliferation	NOUN
bam-5830	422	13	and	and	CCONJ
bam-5830	422	14	myotube	myotube	VERB
bam-5830	422	15	formation	formation	NOUN
bam-5830	422	16	in	in	ADP
bam-5830	422	17	a	a	DET
bam-5830	422	18	wnt1	wnt1	NOUN
bam-5830	422	19	and	and	CCONJ
bam-5830	422	20	wnt3a	wnt3a	X
bam-5830	422	21	dependent	dependent	ADJ
bam-5830	422	22	manner	manner	NOUN
bam-5830	422	23	.	.	PUNCT
bam-5830	423	1	we	we	PRON
bam-5830	423	2	present	present	VERB
bam-5830	423	3	a	a	DET
bam-5830	423	4	model	model	NOUN
bam-5830	423	5	how	how	SCONJ
bam-5830	423	6	canonical	canonical	ADJ
bam-5830	423	7	wnt/-catenin	wnt/-catenin	PROPN
bam-5830	423	8	signaling	signaling	NOUN
bam-5830	423	9	,	,	PUNCT
bam-5830	423	10	together	together	ADV
bam-5830	423	11	with	with	ADP
bam-5830	423	12	yap	yap	PROPN
bam-5830	423	13	/	/	SYM
bam-5830	423	14	taz	taz	PROPN
bam-5830	423	15	and	and	CCONJ
bam-5830	423	16	tead1	tead1	PROPN
bam-5830	423	17	,	,	PUNCT
bam-5830	423	18	influences	influence	VERB
bam-5830	423	19	muscle	muscle	NOUN
bam-5830	423	20	fiber	fiber	NOUN
bam-5830	423	21	diameter	diameter	NOUN
bam-5830	423	22	in	in	ADP
bam-5830	423	23	fiber	fiber	NOUN
bam-5830	423	24	-	-	PUNCT
bam-5830	423	25	type	type	NOUN
bam-5830	423	26	specific	specific	ADJ
bam-5830	423	27	manner	manner	NOUN
bam-5830	423	28	.	.	PUNCT
bam-5830	424	1	*	*	PUNCT
bam-5830	425	1	*	*	PUNCT
bam-5830	425	2	*	*	PUNCT
bam-5830	425	3	*	*	PUNCT
bam-5830	425	4	*	*	PUNCT
bam-5830	425	5	the	the	DET
bam-5830	425	6	mitochondrial	mitochondrial	ADJ
bam-5830	425	7	calcium	calcium	NOUN
bam-5830	425	8	uniporter	uniporter	NOUN
bam-5830	425	9	controls	control	VERB
bam-5830	425	10	skeletal	skeletal	ADJ
bam-5830	425	11	muscle	muscle	NOUN
bam-5830	425	12	trophism	trophism	NOUN
bam-5830	425	13	in	in	ADP
bam-5830	425	14	vivo	vivo	NOUN
bam-5830	425	15	g.	g.	PROPN
bam-5830	425	16	gherardi	gherardi	PROPN
bam-5830	425	17	1	1	NUM
bam-5830	425	18	,	,	PUNCT
bam-5830	425	19	c.	c.	PROPN
bam-5830	425	20	mammucari	mammucari	PROPN
bam-5830	425	21	1	1	NUM
bam-5830	425	22	,	,	PUNCT
bam-5830	425	23	i.	i.	PROPN
bam-5830	425	24	zamparo	zamparo	PROPN
bam-5830	425	25	1	1	NUM
bam-5830	425	26	,	,	PUNCT
bam-5830	425	27	a.	a.	PROPN
bam-5830	425	28	raffaello	raffaello	PROPN
bam-5830	425	29	1	1	NUM
bam-5830	425	30	,	,	PUNCT
bam-5830	425	31	s.	s.	PROPN
bam-5830	425	32	boncompagni	boncompagni	PROPN
bam-5830	425	33	2	2	NUM
bam-5830	425	34	,	,	PUNCT
bam-5830	425	35	f.	f.	PROPN
bam-5830	425	36	chemello	chemello	PROPN
bam-5830	425	37	3	3	NUM
bam-5830	425	38	,	,	PUNCT
bam-5830	425	39	s.	s.	PROPN
bam-5830	425	40	cagnin	cagnin	PROPN
bam-5830	425	41	3	3	NUM
bam-5830	425	42	,	,	PUNCT
bam-5830	425	43	a.	a.	NOUN
bam-5830	425	44	braga	braga	NOUN
bam-5830	425	45	1	1	NUM
bam-5830	425	46	,	,	PUNCT
bam-5830	425	47	s.	s.	PROPN
bam-5830	425	48	zanin	zanin	PROPN
bam-5830	425	49	1	1	NUM
bam-5830	425	50	,	,	PUNCT
bam-5830	425	51	g.	g.	PROPN
bam-5830	425	52	pallafacchina	pallafacchina	PROPN
bam-5830	425	53	1,4	1,4	PROPN
bam-5830	425	54	,	,	PUNCT
bam-5830	425	55	l.	l.	PROPN
bam-5830	425	56	zentilin	zentilin	PROPN
bam-5830	425	57	5	5	NUM
bam-5830	425	58	,	,	PUNCT
bam-5830	425	59	m.	m.	NOUN
bam-5830	425	60	sandri	sandri	NOUN
bam-5830	425	61	1,4,6,7	1,4,6,7	NUM
bam-5830	425	62	,	,	PUNCT
bam-5830	425	63	d.	d.	PROPN
bam-5830	425	64	de	de	PROPN
bam-5830	425	65	stefani	stefani	PROPN
bam-5830	425	66	1	1	NUM
bam-5830	425	67	,	,	PUNCT
bam-5830	425	68	f.	f.	PROPN
bam-5830	425	69	protasi	protasi	PROPN
bam-5830	425	70	2	2	NUM
bam-5830	425	71	,	,	PUNCT
bam-5830	425	72	g.	g.	PROPN
bam-5830	425	73	lanfranchi	lanfranchi	PROPN
bam-5830	425	74	3	3	NUM
bam-5830	425	75	,	,	PUNCT
bam-5830	425	76	r.	r.	PROPN
bam-5830	425	77	rizzuto	rizzuto	PROPN
bam-5830	425	78	1,4	1,4	NUM
bam-5830	425	79	1	1	NUM
bam-5830	425	80	.	.	PUNCT
bam-5830	426	1	department	department	NOUN
bam-5830	426	2	of	of	ADP
bam-5830	426	3	biomedical	biomedical	ADJ
bam-5830	426	4	sciences	sciences	PROPN
bam-5830	426	5	,	,	PUNCT
bam-5830	426	6	university	university	NOUN
bam-5830	426	7	of	of	ADP
bam-5830	426	8	padua	padua	PROPN
bam-5830	426	9	;	;	PUNCT
bam-5830	426	10	2.ce.s.i	2.ce.s.i	X
bam-5830	426	11	.	.	NOUN
bam-5830	426	12	center	center	NOUN
bam-5830	426	13	for	for	ADP
bam-5830	426	14	research	research	NOUN
bam-5830	426	15	on	on	ADP
bam-5830	426	16	ageing	ageing	NOUN
bam-5830	426	17	and	and	CCONJ
bam-5830	426	18	d.n.i.c.s	d.n.i.c.	NOUN
bam-5830	426	19	.	.	PUNCT
bam-5830	427	1	department	department	NOUN
bam-5830	427	2	of	of	ADP
bam-5830	427	3	neuroscience	neuroscience	NOUN
bam-5830	427	4	,	,	PUNCT
bam-5830	427	5	imaging	imaging	NOUN
bam-5830	427	6	and	and	CCONJ
bam-5830	427	7	clinical	clinical	ADJ
bam-5830	427	8	sciences	science	NOUN
bam-5830	427	9	,	,	PUNCT
bam-5830	427	10	university	university	NOUN
bam-5830	427	11	"	"	PUNCT
bam-5830	427	12	g.	g.	PROPN
bam-5830	427	13	d	d	PROPN
bam-5830	427	14	annunzio	annunzio	PROPN
bam-5830	427	15	"	"	PUNCT
bam-5830	427	16	of	of	ADP
bam-5830	427	17	chieti	chieti	PROPN
bam-5830	427	18	;	;	PUNCT
bam-5830	427	19	3	3	X
bam-5830	427	20	.	.	X
bam-5830	427	21	department	department	NOUN
bam-5830	427	22	of	of	ADP
bam-5830	427	23	biology	biology	NOUN
bam-5830	427	24	and	and	CCONJ
bam-5830	427	25	cribi	cribi	NOUN
bam-5830	427	26	biotechnology	biotechnology	NOUN
bam-5830	427	27	center	center	NOUN
bam-5830	427	28	,	,	PUNCT
bam-5830	427	29	university	university	PROPN
bam-5830	427	30	of	of	ADP
bam-5830	427	31	padua	padua	PROPN
bam-5830	427	32	;	;	PUNCT
bam-5830	427	33	4	4	X
bam-5830	427	34	.	.	X
bam-5830	427	35	neuroscience	neuroscience	PROPN
bam-5830	427	36	institute	institute	PROPN
bam-5830	427	37	,	,	PUNCT
bam-5830	427	38	national	national	PROPN
bam-5830	427	39	research	research	PROPN
bam-5830	427	40	council	council	PROPN
bam-5830	427	41	,	,	PUNCT
bam-5830	427	42	padua	padua	PROPN
bam-5830	427	43	,	,	PUNCT
bam-5830	427	44	italy	italy	PROPN
bam-5830	427	45	:	:	PUNCT
bam-5830	427	46	5	5	X
bam-5830	427	47	.	.	X
bam-5830	427	48	international	international	ADJ
bam-5830	427	49	centre	centre	NOUN
bam-5830	427	50	for	for	ADP
bam-5830	427	51	genetic	genetic	ADJ
bam-5830	427	52	engineering	engineering	NOUN
bam-5830	427	53	and	and	CCONJ
bam-5830	427	54	biotechnology	biotechnology	NOUN
bam-5830	427	55	(	(	PUNCT
bam-5830	427	56	icgeb	icgeb	PROPN
bam-5830	427	57	)	)	PUNCT
bam-5830	427	58	,	,	PUNCT
bam-5830	427	59	trieste	trieste	VERB
bam-5830	427	60	;	;	PUNCT
bam-5830	427	61	6	6	X
bam-5830	427	62	.	.	X
bam-5830	427	63	dulbecco	dulbecco	PROPN
bam-5830	427	64	telethon	telethon	PROPN
bam-5830	427	65	institute	institute	NOUN
bam-5830	427	66	at	at	ADP
bam-5830	427	67	vimm	vimm	PROPN
bam-5830	427	68	,	,	PUNCT
bam-5830	427	69	padua	padua	PROPN
bam-5830	427	70	;	;	PUNCT
bam-5830	427	71	7	7	X
bam-5830	427	72	.	.	X
bam-5830	427	73	telethon	telethon	PROPN
bam-5830	427	74	institute	institute	PROPN
bam-5830	427	75	of	of	ADP
bam-5830	427	76	genetics	genetic	NOUN
bam-5830	427	77	and	and	CCONJ
bam-5830	427	78	medicine	medicine	NOUN
bam-5830	427	79	,	,	PUNCT
bam-5830	427	80	naples	naples	PROPN
bam-5830	427	81	,	,	PUNCT
bam-5830	427	82	italy	italy	PROPN
bam-5830	427	83	e	e	PROPN
bam-5830	427	84	-	-	NOUN
bam-5830	427	85	mail	mail	NOUN
bam-5830	427	86	:	:	PUNCT
bam-5830	427	87	gaia.gherardi88@gmail.com	gaia.gherardi88@gmail.com	X
bam-5830	427	88	muscle	muscle	NOUN
bam-5830	427	89	atrophy	atrophy	NOUN
bam-5830	427	90	contributes	contribute	VERB
bam-5830	427	91	to	to	ADP
bam-5830	427	92	the	the	DET
bam-5830	427	93	poor	poor	ADJ
bam-5830	427	94	prognosis	prognosis	NOUN
bam-5830	427	95	of	of	ADP
bam-5830	427	96	many	many	ADJ
bam-5830	427	97	pathophysiological	pathophysiological	ADJ
bam-5830	427	98	conditions	condition	NOUN
bam-5830	427	99	,	,	PUNCT
bam-5830	427	100	but	but	CCONJ
bam-5830	427	101	pharmacological	pharmacological	ADJ
bam-5830	427	102	therapies	therapy	NOUN
bam-5830	427	103	are	be	AUX
bam-5830	427	104	still	still	ADV
bam-5830	427	105	limited	limited	ADJ
bam-5830	427	106	.	.	PUNCT
bam-5830	428	1	muscle	muscle	NOUN
bam-5830	428	2	activity	activity	NOUN
bam-5830	428	3	leads	lead	VERB
bam-5830	428	4	to	to	ADP
bam-5830	428	5	major	major	ADJ
bam-5830	428	6	swings	swing	NOUN
bam-5830	428	7	in	in	ADP
bam-5830	428	8	mitochondrial	mitochondrial	ADJ
bam-5830	428	9	[	[	X
bam-5830	428	10	ca2	ca2	PROPN
bam-5830	428	11	+	+	PROPN
bam-5830	428	12	]	]	X
bam-5830	428	13	which	which	PRON
bam-5830	428	14	control	control	VERB
bam-5830	428	15	aerobic	aerobic	ADJ
bam-5830	428	16	metabolism	metabolism	NOUN
bam-5830	428	17	,	,	PUNCT
bam-5830	428	18	cell	cell	NOUN
bam-5830	428	19	death	death	NOUN
bam-5830	428	20	and	and	CCONJ
bam-5830	428	21	survival	survival	NOUN
bam-5830	428	22	pathways	pathway	NOUN
bam-5830	428	23	.	.	PUNCT
bam-5830	429	1	we	we	PRON
bam-5830	429	2	have	have	AUX
bam-5830	429	3	investigated	investigate	VERB
bam-5830	429	4	in	in	ADP
bam-5830	429	5	vivo	vivo	NOUN
bam-5830	429	6	the	the	DET
bam-5830	429	7	effects	effect	NOUN
bam-5830	429	8	of	of	ADP
bam-5830	429	9	mitochondrial	mitochondrial	ADJ
bam-5830	429	10	ca2	ca2	PROPN
bam-5830	429	11	+	+	NOUN
bam-5830	429	12	homeostasis	homeostasis	NOUN
bam-5830	429	13	in	in	ADP
bam-5830	429	14	skeletal	skeletal	ADJ
bam-5830	429	15	muscle	muscle	NOUN
bam-5830	429	16	function	function	NOUN
bam-5830	429	17	and	and	CCONJ
bam-5830	429	18	trophism	trophism	NOUN
bam-5830	429	19	,	,	PUNCT
bam-5830	429	20	by	by	ADP
bam-5830	429	21	overexpressing	overexpresse	VERB
bam-5830	429	22	or	or	CCONJ
bam-5830	429	23	silencing	silence	VERB
bam-5830	429	24	the	the	DET
bam-5830	429	25	mitochondrial	mitochondrial	ADJ
bam-5830	429	26	calcium	calcium	NOUN
bam-5830	429	27	uniporter	uniporter	NOUN
bam-5830	429	28	(	(	PUNCT
bam-5830	429	29	mcu	mcu	NOUN
bam-5830	429	30	)	)	PUNCT
bam-5830	429	31	.	.	PUNCT
bam-5830	430	1	the	the	DET
bam-5830	430	2	results	result	NOUN
bam-5830	430	3	demonstrate	demonstrate	VERB
bam-5830	430	4	that	that	SCONJ
bam-5830	430	5	both	both	CCONJ
bam-5830	430	6	in	in	ADP
bam-5830	430	7	developing	develop	VERB
bam-5830	430	8	and	and	CCONJ
bam-5830	430	9	in	in	ADP
bam-5830	430	10	adult	adult	NOUN
bam-5830	430	11	muscles	muscle	NOUN
bam-5830	430	12	mcu	mcu	NOUN
bam-5830	430	13	-	-	PUNCT
bam-5830	430	14	dependent	dependent	ADJ
bam-5830	430	15	mitochondrial	mitochondrial	ADJ
bam-5830	430	16	ca2	ca2	PROPN
bam-5830	430	17	+	+	PROPN
bam-5830	431	1	uptake	uptake	NOUN
bam-5830	431	2	has	have	VERB
bam-5830	431	3	a	a	DET
bam-5830	431	4	marked	mark	VERB
bam-5830	431	5	trophic	trophic	ADJ
bam-5830	431	6	effect	effect	NOUN
bam-5830	431	7	that	that	PRON
bam-5830	431	8	does	do	AUX
bam-5830	431	9	not	not	PART
bam-5830	431	10	depend	depend	VERB
bam-5830	431	11	on	on	ADP
bam-5830	431	12	aerobic	aerobic	ADJ
bam-5830	431	13	control	control	NOUN
bam-5830	431	14	,	,	PUNCT
bam-5830	431	15	but	but	CCONJ
bam-5830	431	16	impinges	impinge	VERB
bam-5830	431	17	on	on	ADP
bam-5830	431	18	two	two	NUM
bam-5830	431	19	major	major	ADJ
bam-5830	431	20	hypertrophic	hypertrophic	ADJ
bam-5830	431	21	pathways	pathway	NOUN
bam-5830	431	22	of	of	ADP
bam-5830	431	23	skeletal	skeletal	ADJ
bam-5830	431	24	muscle	muscle	NOUN
bam-5830	431	25	,	,	PUNCT
bam-5830	431	26	pgc-14	pgc-14	NOUN
bam-5830	431	27	and	and	CCONJ
bam-5830	431	28	igf1	igf1	PROPN
bam-5830	431	29	-	-	PUNCT
bam-5830	431	30	akt	akt	PROPN
bam-5830	431	31	/	/	SYM
bam-5830	431	32	pkb	pkb	PROPN
bam-5830	431	33	.	.	PUNCT
bam-5830	432	1	in	in	ADP
bam-5830	432	2	addition	addition	NOUN
bam-5830	432	3	,	,	PUNCT
bam-5830	432	4	mcu	mcu	NOUN
bam-5830	432	5	overexpression	overexpression	NOUN
bam-5830	432	6	protects	protect	VERB
bam-5830	432	7	from	from	ADP
bam-5830	432	8	denervation	denervation	NOUN
bam-5830	432	9	-	-	PUNCT
bam-5830	432	10	induced	induce	VERB
bam-5830	432	11	atrophy	atrophy	NOUN
bam-5830	432	12	.	.	PUNCT
bam-5830	433	1	these	these	DET
bam-5830	433	2	data	datum	NOUN
bam-5830	433	3	reveal	reveal	VERB
bam-5830	433	4	a	a	DET
bam-5830	433	5	novel	novel	ADJ
bam-5830	433	6	ca2	ca2	PROPN
bam-5830	433	7	+	+	ADJ
bam-5830	433	8	-dependent	-dependent	ADJ
bam-5830	433	9	organelle	organelle	NOUN
bam-5830	433	10	-	-	PUNCT
bam-5830	433	11	tonucleus	tonucleus	NOUN
bam-5830	433	12	signaling	signal	VERB
bam-5830	433	13	route	route	NOUN
bam-5830	433	14	,	,	PUNCT
bam-5830	433	15	which	which	PRON
bam-5830	433	16	links	link	VERB
bam-5830	433	17	mitochondrial	mitochondrial	ADJ
bam-5830	433	18	function	function	NOUN
bam-5830	433	19	to	to	ADP
bam-5830	433	20	the	the	DET
bam-5830	433	21	control	control	NOUN
bam-5830	433	22	of	of	ADP
bam-5830	433	23	muscle	muscle	NOUN
bam-5830	433	24	mass	mass	NOUN
bam-5830	433	25	and	and	CCONJ
bam-5830	433	26	may	may	AUX
bam-5830	433	27	represent	represent	VERB
bam-5830	433	28	a	a	DET
bam-5830	433	29	possible	possible	ADJ
bam-5830	433	30	pharmacological	pharmacological	ADJ
bam-5830	433	31	target	target	NOUN
bam-5830	433	32	in	in	ADP
bam-5830	433	33	conditions	condition	NOUN
bam-5830	433	34	of	of	ADP
bam-5830	433	35	muscle	muscle	NOUN
bam-5830	433	36	loss	loss	NOUN
bam-5830	433	37	.	.	PUNCT
bam-5830	434	1	*	*	PUNCT
bam-5830	434	2	*	*	PUNCT
bam-5830	434	3	*	*	PUNCT
bam-5830	434	4	*	*	PUNCT
bam-5830	434	5	*	*	NOUN
bam-5830	434	6	role	role	NOUN
bam-5830	434	7	of	of	ADP
bam-5830	434	8	atypical	atypical	ADJ
bam-5830	434	9	pkcs	pkcs	NOUN
bam-5830	434	10	in	in	ADP
bam-5830	434	11	skeletal	skeletal	ADJ
bam-5830	434	12	muscle	muscle	NOUN
bam-5830	434	13	homeostasis	homeostasis	NOUN
bam-5830	434	14	a.	a.	NOUN
bam-5830	434	15	braga	braga	NOUN
bam-5830	434	16	,	,	PUNCT
bam-5830	434	17	r.	r.	PROPN
bam-5830	434	18	rizzuto	rizzuto	PROPN
bam-5830	434	19	,	,	PUNCT
bam-5830	434	20	c.	c.	PROPN
bam-5830	434	21	mammucari	mammucari	PROPN
bam-5830	434	22	department	department	PROPN
bam-5830	434	23	of	of	ADP
bam-5830	434	24	biomedical	biomedical	ADJ
bam-5830	434	25	sciences	sciences	PROPN
bam-5830	434	26	,	,	PUNCT
bam-5830	434	27	university	university	PROPN
bam-5830	434	28	of	of	ADP
bam-5830	434	29	padua	padua	PROPN
bam-5830	434	30	,	,	PUNCT
bam-5830	434	31	padua	padua	PROPN
bam-5830	434	32	,	,	PUNCT
bam-5830	434	33	italy	italy	PROPN
bam-5830	434	34	e	e	PROPN
bam-5830	434	35	-	-	NOUN
bam-5830	434	36	mail	mail	NOUN
bam-5830	434	37	:	:	PUNCT
bam-5830	434	38	alessandra.braga@unipd.it	alessandra.braga@unipd.it	PROPN
bam-5830	434	39	pkc	pkc	PROPN
bam-5830	434	40	(	(	PUNCT
bam-5830	434	41	protein	protein	NOUN
bam-5830	434	42	kinase	kinase	NOUN
bam-5830	434	43	c	c	PROPN
bam-5830	434	44	)	)	PUNCT
bam-5830	434	45	family	family	NOUN
bam-5830	434	46	is	be	AUX
bam-5830	434	47	composed	compose	VERB
bam-5830	434	48	by	by	ADP
bam-5830	434	49	3	3	NUM
bam-5830	434	50	subgroups	subgroup	NOUN
bam-5830	434	51	:	:	PUNCT
bam-5830	434	52	conventional	conventional	ADJ
bam-5830	434	53	,	,	PUNCT
bam-5830	434	54	novel	novel	ADJ
bam-5830	434	55	and	and	CCONJ
bam-5830	434	56	atypical	atypical	ADJ
bam-5830	434	57	pkc	pkc	NOUN
bam-5830	434	58	.	.	PUNCT
bam-5830	435	1	these	these	DET
bam-5830	435	2	kinases	kinase	NOUN
bam-5830	435	3	are	be	AUX
bam-5830	435	4	involved	involve	VERB
bam-5830	435	5	in	in	ADP
bam-5830	435	6	a	a	DET
bam-5830	435	7	large	large	ADJ
bam-5830	435	8	number	number	NOUN
bam-5830	435	9	of	of	ADP
bam-5830	435	10	biological	biological	ADJ
bam-5830	435	11	processes	process	NOUN
bam-5830	435	12	(	(	PUNCT
bam-5830	435	13	such	such	ADJ
bam-5830	435	14	as	as	ADP
bam-5830	435	15	protein	protein	NOUN
bam-5830	435	16	synthesis	synthesis	NOUN
bam-5830	435	17	,	,	PUNCT
bam-5830	435	18	glucose	glucose	NOUN
bam-5830	435	19	metabolism	metabolism	NOUN
bam-5830	435	20	,	,	PUNCT
bam-5830	435	21	apoptosis	apoptosis	NOUN
bam-5830	435	22	)	)	PUNCT
bam-5830	435	23	.	.	PUNCT
bam-5830	436	1	pkczeta	pkczeta	ADJ
bam-5830	436	2	and	and	CCONJ
bam-5830	436	3	pkclambda	pkclambda	ADJ
bam-5830	436	4	/	/	SYM
bam-5830	436	5	iota	iota	NOUN
bam-5830	436	6	belong	belong	VERB
bam-5830	436	7	to	to	ADP
bam-5830	436	8	the	the	DET
bam-5830	436	9	atypical	atypical	ADJ
bam-5830	436	10	pkc	pkc	PROPN
bam-5830	436	11	subgroup	subgroup	NOUN
bam-5830	436	12	and	and	CCONJ
bam-5830	436	13	differ	differ	VERB
bam-5830	436	14	from	from	ADP
bam-5830	436	15	conventional	conventional	ADJ
bam-5830	436	16	and	and	CCONJ
bam-5830	436	17	novel	novel	ADJ
bam-5830	436	18	pkcs	pkcs	NOUN
bam-5830	436	19	for	for	ADP
bam-5830	436	20	their	their	PRON
bam-5830	436	21	activation	activation	NOUN
bam-5830	436	22	mechanism	mechanism	NOUN
bam-5830	436	23	.	.	PUNCT
bam-5830	437	1	indeed	indeed	ADV
bam-5830	437	2	atypical	atypical	ADJ
bam-5830	437	3	pkcs	pkcs	NOUN
bam-5830	437	4	are	be	AUX
bam-5830	437	5	calcium	calcium	NOUN
bam-5830	437	6	and	and	CCONJ
bam-5830	437	7	diacylglycerol	diacylglycerol	NOUN
bam-5830	437	8	(	(	PUNCT
bam-5830	437	9	dag	dag	NOUN
bam-5830	437	10	)	)	PUNCT
bam-5830	437	11	insensitive	insensitive	ADJ
bam-5830	437	12	,	,	PUNCT
bam-5830	437	13	while	while	SCONJ
bam-5830	437	14	classical	classical	ADJ
bam-5830	437	15	pkcs	pkcs	NOUN
bam-5830	437	16	are	be	AUX
bam-5830	437	17	activated	activate	VERB
bam-5830	437	18	by	by	ADP
bam-5830	437	19	calcium	calcium	NOUN
bam-5830	437	20	and	and	CCONJ
bam-5830	437	21	dag	dag	PROPN
bam-5830	437	22	,	,	PUNCT
bam-5830	437	23	and	and	CCONJ
bam-5830	437	24	novel	novel	NOUN
bam-5830	437	25	pkcs	pkcs	NOUN
bam-5830	437	26	are	be	AUX
bam-5830	437	27	activated	activate	VERB
bam-5830	437	28	by	by	ADP
bam-5830	437	29	dag	dag	PROPN
bam-5830	437	30	but	but	CCONJ
bam-5830	437	31	not	not	PART
bam-5830	437	32	by	by	ADP
bam-5830	437	33	calcium	calcium	NOUN
bam-5830	437	34	(	(	PUNCT
bam-5830	437	35	1,2	1,2	NUM
bam-5830	437	36	)	)	PUNCT
bam-5830	437	37	.	.	PUNCT
bam-5830	438	1	little	little	ADJ
bam-5830	438	2	is	be	AUX
bam-5830	438	3	known	know	VERB
bam-5830	438	4	on	on	ADP
bam-5830	438	5	the	the	DET
bam-5830	438	6	role	role	NOUN
bam-5830	438	7	of	of	ADP
bam-5830	438	8	pkczeta	pkczeta	NOUN
bam-5830	438	9	on	on	ADP
bam-5830	438	10	skeletal	skeletal	ADJ
bam-5830	438	11	muscle	muscle	NOUN
bam-5830	438	12	homeostasis	homeostasis	NOUN
bam-5830	438	13	.	.	PUNCT
bam-5830	439	1	thus	thus	ADV
bam-5830	439	2	,	,	PUNCT
bam-5830	439	3	we	we	PRON
bam-5830	439	4	overexpressed	overexpresse	VERB
bam-5830	439	5	this	this	DET
bam-5830	439	6	kinase	kinase	NOUN
bam-5830	439	7	by	by	ADP
bam-5830	439	8	in	in	ADP
bam-5830	439	9	vivo	vivo	ADJ
bam-5830	439	10	transient	transient	NOUN
bam-5830	439	11	transfection	transfection	NOUN
bam-5830	439	12	.	.	PUNCT
bam-5830	440	1	we	we	PRON
bam-5830	440	2	observed	observe	VERB
bam-5830	440	3	a	a	DET
bam-5830	440	4	marked	mark	VERB
bam-5830	440	5	hypertrophy	hypertrophy	NOUN
bam-5830	440	6	in	in	ADP
bam-5830	440	7	pkczeta	pkczeta	ADJ
bam-5830	440	8	positive	positive	ADJ
bam-5830	440	9	myofibers	myofiber	NOUN
bam-5830	440	10	compared	compare	VERB
bam-5830	440	11	to	to	ADP
bam-5830	440	12	surrounding	surround	VERB
bam-5830	440	13	not	not	PART
bam-5830	440	14	transfected	transfecte	VERB
bam-5830	440	15	fibers	fiber	NOUN
bam-5830	440	16	.	.	PUNCT
bam-5830	441	1	in	in	ADP
bam-5830	441	2	addition	addition	NOUN
bam-5830	441	3	pkczeta	pkczeta	ADJ
bam-5830	441	4	overexpression	overexpression	NOUN
bam-5830	441	5	protected	protect	VERB
bam-5830	441	6	muscle	muscle	NOUN
bam-5830	441	7	from	from	ADP
bam-5830	441	8	denervation	denervation	NOUN
bam-5830	441	9	-	-	PUNCT
bam-5830	441	10	induced	induce	VERB
bam-5830	441	11	atrophy	atrophy	NOUN
bam-5830	441	12	.	.	PUNCT
bam-5830	442	1	next	next	ADV
bam-5830	442	2	,	,	PUNCT
bam-5830	442	3	we	we	PRON
bam-5830	442	4	studied	study	VERB
bam-5830	442	5	the	the	DET
bam-5830	442	6	effects	effect	NOUN
bam-5830	442	7	of	of	ADP
bam-5830	442	8	3	3	NUM
bam-5830	442	9	different	different	ADJ
bam-5830	442	10	pkczeta	pkczeta	ADJ
bam-5830	442	11	mutants	mutant	NOUN
bam-5830	442	12	on	on	ADP
bam-5830	442	13	fiber	fiber	NOUN
bam-5830	442	14	size	size	NOUN
bam-5830	442	15	:	:	PUNCT
bam-5830	442	16	1	1	X
bam-5830	442	17	)	)	PUNCT
bam-5830	442	18	pkczeta	pkczeta	ADJ
bam-5830	442	19	-	-	ADJ
bam-5830	442	20	dn	dn	ADJ
bam-5830	442	21	(	(	PUNCT
bam-5830	442	22	a	a	DET
bam-5830	442	23	dominant	dominant	ADJ
bam-5830	442	24	negative	negative	ADJ
bam-5830	442	25	isoform	isoform	NOUN
bam-5830	442	26	carrying	carry	VERB
bam-5830	442	27	a	a	DET
bam-5830	442	28	point	point	NOUN
bam-5830	442	29	mutation	mutation	NOUN
bam-5830	442	30	on	on	ADP
bam-5830	442	31	the	the	DET
bam-5830	442	32	atp	atp	NOUN
bam-5830	442	33	-	-	PUNCT
bam-5830	442	34	binding	bind	VERB
bam-5830	442	35	site	site	NOUN
bam-5830	442	36	)	)	PUNCT
bam-5830	442	37	;	;	PUNCT
bam-5830	442	38	2	2	X
bam-5830	442	39	)	)	PUNCT
bam-5830	442	40	pkczeta	pkczeta	ADJ
bam-5830	442	41	-	-	PUNCT
bam-5830	442	42	δnps	δnps	NOUN
bam-5830	442	43	(	(	PUNCT
bam-5830	442	44	a	a	DET
bam-5830	442	45	costitutive	costitutive	ADJ
bam-5830	442	46	active	active	ADJ
bam-5830	442	47	mutant	mutant	NOUN
bam-5830	442	48	)	)	PUNCT
bam-5830	442	49	;	;	PUNCT
bam-5830	442	50	3	3	X
bam-5830	442	51	)	)	PUNCT
bam-5830	442	52	pkczeta	pkczeta	ADJ
bam-5830	442	53	-	-	ADJ
bam-5830	442	54	inloop	inloop	NOUN
bam-5830	442	55	(	(	PUNCT
bam-5830	442	56	a	a	DET
bam-5830	442	57	dominant	dominant	ADJ
bam-5830	442	58	negative	negative	ADJ
bam-5830	442	59	isoform	isoform	NOUN
bam-5830	442	60	mutated	mutate	VERB
bam-5830	442	61	in	in	ADP
bam-5830	442	62	the	the	DET
bam-5830	442	63	activation	activation	NOUN
bam-5830	442	64	loop	loop	NOUN
bam-5830	442	65	)	)	PUNCT
bam-5830	442	66	.	.	PUNCT
bam-5830	443	1	surprisingly	surprisingly	ADV
bam-5830	443	2	all	all	DET
bam-5830	443	3	these	these	DET
bam-5830	443	4	mutants	mutant	NOUN
bam-5830	443	5	cause	cause	VERB
bam-5830	443	6	muscle	muscle	NOUN
bam-5830	443	7	hypertrophy	hypertrophy	NOUN
bam-5830	443	8	and	and	CCONJ
bam-5830	443	9	protect	protect	VERB
bam-5830	443	10	from	from	ADP
bam-5830	443	11	denervationinduced	denervationinduced	ADJ
bam-5830	443	12	atrophy	atrophy	NOUN
bam-5830	443	13	suggesting	suggest	VERB
bam-5830	443	14	a	a	DET
bam-5830	443	15	possible	possible	ADJ
bam-5830	443	16	kinase	kinase	ADJ
bam-5830	443	17	-	-	PUNCT
bam-5830	443	18	independent	independent	ADJ
bam-5830	443	19	mechanism	mechanism	NOUN
bam-5830	443	20	of	of	ADP
bam-5830	443	21	pkczeta	pkczeta	NOUN
bam-5830	443	22	on	on	ADP
bam-5830	443	23	skeletal	skeletal	ADJ
bam-5830	443	24	muscle	muscle	NOUN
bam-5830	443	25	trophism	trophism	NOUN
bam-5830	443	26	.	.	PUNCT
bam-5830	444	1	1	1	X
bam-5830	444	2	.	.	X
bam-5830	444	3	liu	liu	PROPN
bam-5830	444	4	xj	xj	PROPN
bam-5830	444	5	,	,	PUNCT
bam-5830	444	6	he	he	PRON
bam-5830	444	7	ab	ab	PROPN
bam-5830	444	8	,	,	PUNCT
bam-5830	444	9	chang	chang	PROPN
bam-5830	444	10	ys	ys	PROPN
bam-5830	444	11	,	,	PUNCT
bam-5830	444	12	fang	fang	X
bam-5830	444	13	fd	fd	PROPN
bam-5830	444	14	.	.	PUNCT
bam-5830	444	15	atypical	atypical	ADJ
bam-5830	444	16	protein	protein	NOUN
bam-5830	444	17	kinase	kinase	NOUN
bam-5830	444	18	c	c	PROPN
bam-5830	444	19	in	in	ADP
bam-5830	444	20	glucose	glucose	NOUN
bam-5830	444	21	metabolism	metabolism	NOUN
bam-5830	444	22	.	.	PUNCT
bam-5830	445	1	cell	cell	NOUN
bam-5830	445	2	signal	signal	VERB
bam-5830	445	3	2006	2006	NUM
bam-5830	445	4	dec;18(12):2071	dec;18(12):2071	NOUN
bam-5830	445	5	-	-	PUNCT
bam-5830	445	6	6	6	NUM
bam-5830	445	7	.	.	NOUN
bam-5830	445	8	2	2	NUM
bam-5830	445	9	.	.	X
bam-5830	445	10	farese	farese	PROPN
bam-5830	445	11	rv	rv	PROPN
bam-5830	445	12	,	,	PUNCT
bam-5830	445	13	sajan	sajan	PROPN
bam-5830	445	14	mp	mp	PROPN
bam-5830	445	15	.	.	PROPN
bam-5830	445	16	metabolic	metabolic	PROPN
bam-5830	445	17	functions	function	NOUN
bam-5830	445	18	of	of	ADP
bam-5830	445	19	atypical	atypical	ADJ
bam-5830	445	20	protein	protein	NOUN
bam-5830	445	21	kinase	kinase	NOUN
bam-5830	446	1	c	c	NOUN
bam-5830	446	2	:	:	PUNCT
bam-5830	446	3	"	"	PUNCT
bam-5830	446	4	good	good	ADJ
bam-5830	446	5	"	"	PUNCT
bam-5830	446	6	and	and	CCONJ
bam-5830	446	7	"	"	PUNCT
bam-5830	446	8	bad	bad	ADJ
bam-5830	446	9	"	"	PUNCT
bam-5830	446	10	as	as	SCONJ
bam-5830	446	11	defined	define	VERB
bam-5830	446	12	by	by	ADP
bam-5830	446	13	nutritional	nutritional	ADJ
bam-5830	446	14	status	status	NOUN
bam-5830	446	15	.	.	PUNCT
bam-5830	447	1	am	be	AUX
bam-5830	447	2	j	j	PROPN
bam-5830	447	3	physiol	physiol	PROPN
bam-5830	447	4	endocrinol	endocrinol	VERB
bam-5830	447	5	metab	metab	NOUN
bam-5830	447	6	2009	2009	NUM
bam-5830	447	7	dec;298(3):e385	dec;298(3):e385	PROPN
bam-5830	447	8	-	-	PUNCT
bam-5830	447	9	94	94	NUM
bam-5830	447	10	.	.	PUNCT
bam-5830	448	1	*	*	PUNCT
bam-5830	448	2	*	*	PUNCT
bam-5830	448	3	*	*	PUNCT
bam-5830	448	4	*	*	PUNCT
bam-5830	448	5	*	*	AUX
bam-5830	448	6	pak1	pak1	PROPN
bam-5830	448	7	positively	positively	ADV
bam-5830	448	8	modulates	modulate	VERB
bam-5830	448	9	p38	p38	NOUN
bam-5830	448	10	activation	activation	NOUN
bam-5830	448	11	during	during	ADP
bam-5830	448	12	myogenic	myogenic	ADJ
bam-5830	448	13	differentiation	differentiation	NOUN
bam-5830	448	14	and	and	CCONJ
bam-5830	448	15	muscle	muscle	NOUN
bam-5830	448	16	regeneration	regeneration	NOUN
bam-5830	448	17	a.	a.	NOUN
bam-5830	448	18	cerquone	cerquone	NOUN
bam-5830	448	19	perpetuini	perpetuini	NOUN
bam-5830	448	20	,	,	PUNCT
bam-5830	448	21	c.	c.	NOUN
bam-5830	448	22	fuoco	fuoco	NOUN
bam-5830	448	23	,	,	PUNCT
bam-5830	448	24	g.	g.	PROPN
bam-5830	448	25	desiderio	desiderio	PROPN
bam-5830	448	26	,	,	PUNCT
bam-5830	448	27	l.	l.	PROPN
bam-5830	448	28	castagnoli	castagnoli	PROPN
bam-5830	448	29	,	,	PUNCT
bam-5830	448	30	c.	c.	PROPN
bam-5830	448	31	gargioli	gargioli	PROPN
bam-5830	448	32	,	,	PUNCT
bam-5830	448	33	g.	g.	PROPN
bam-5830	448	34	cesareni	cesareni	PROPN
bam-5830	448	35	department	department	PROPN
bam-5830	448	36	of	of	ADP
bam-5830	448	37	biology	biology	NOUN
bam-5830	448	38	,	,	PUNCT
bam-5830	448	39	rome	rome	PROPN
bam-5830	448	40	university	university	NOUN
bam-5830	448	41	tor	tor	PROPN
bam-5830	448	42	vergata	vergata	PROPN
bam-5830	448	43	,	,	PUNCT
bam-5830	448	44	italy	italy	PROPN
bam-5830	448	45	.	.	PUNCT
bam-5830	449	1	e	e	X
bam-5830	449	2	-	-	NOUN
bam-5830	449	3	mail	mail	NOUN
bam-5830	449	4	:	:	PUNCT
bam-5830	449	5	andrea.cerquoneperpetuini@gmail.com	andrea.cerquoneperpetuini@gmail.com	X
bam-5830	449	6	p38	p38	NOUN
bam-5830	449	7	mitogen	mitogen	NOUN
bam-5830	449	8	activated	activate	VERB
bam-5830	449	9	protein	protein	NOUN
bam-5830	449	10	kinases	kinase	NOUN
bam-5830	449	11	(	(	PUNCT
bam-5830	449	12	mapks	mapks	NOUN
bam-5830	449	13	)	)	PUNCT
bam-5830	449	14	are	be	AUX
bam-5830	449	15	required	require	VERB
bam-5830	449	16	at	at	ADP
bam-5830	449	17	several	several	ADJ
bam-5830	449	18	stages	stage	NOUN
bam-5830	449	19	during	during	ADP
bam-5830	449	20	differentiation	differentiation	NOUN
bam-5830	449	21	of	of	ADP
bam-5830	449	22	muscle	muscle	NOUN
bam-5830	449	23	progenitor	progenitor	NOUN
bam-5830	449	24	cells	cell	NOUN
bam-5830	449	25	.	.	PUNCT
bam-5830	450	1	p38	p38	NOUN
bam-5830	450	2	phosphorylation	phosphorylation	NOUN
bam-5830	450	3	initially	initially	ADV
bam-5830	450	4	accompanies	accompany	VERB
bam-5830	450	5	satellite	satellite	NOUN
bam-5830	450	6	cells	cell	NOUN
bam-5830	450	7	activation	activation	NOUN
bam-5830	450	8	and	and	CCONJ
bam-5830	450	9	triggers	trigger	VERB
bam-5830	450	10	asymmetric	asymmetric	ADJ
bam-5830	450	11	division	division	NOUN
bam-5830	450	12	.	.	PUNCT
bam-5830	451	1	at	at	ADP
bam-5830	451	2	a	a	DET
bam-5830	451	3	later	later	ADJ
bam-5830	451	4	stage	stage	NOUN
bam-5830	451	5	,	,	PUNCT
bam-5830	451	6	it	it	PRON
bam-5830	451	7	orchestrates	orchestrate	VERB
bam-5830	451	8	myoblast	myoblast	ADJ
bam-5830	451	9	differentiation	differentiation	NOUN
bam-5830	451	10	promoting	promote	VERB
bam-5830	451	11	myotube	myotube	NOUN
bam-5830	451	12	formation	formation	NOUN
bam-5830	451	13	.	.	PUNCT
bam-5830	452	1	the	the	DET
bam-5830	452	2	signals	signal	NOUN
bam-5830	452	3	that	that	PRON
bam-5830	452	4	trigger	trigger	NOUN
bam-5830	452	5	or	or	CCONJ
bam-5830	452	6	modulate	modulate	VERB
bam-5830	452	7	p38	p38	NOUN
bam-5830	452	8	activation	activation	NOUN
bam-5830	452	9	during	during	ADP
bam-5830	452	10	the	the	DET
bam-5830	452	11	differentiation	differentiation	NOUN
bam-5830	452	12	process	process	NOUN
bam-5830	452	13	are	be	AUX
bam-5830	452	14	still	still	ADV
bam-5830	452	15	debated	debate	VERB
bam-5830	452	16	.	.	PUNCT
bam-5830	453	1	both	both	DET
bam-5830	453	2	celljtojcell	celljtojcell	NOUN
bam-5830	453	3	contact	contact	NOUN
bam-5830	453	4	and	and	CCONJ
bam-5830	453	5	tnfα	tnfα	NOUN
bam-5830	453	6	prime	prime	ADJ
bam-5830	453	7	p38α	p38α	PROPN
bam-5830	453	8	/	/	SYM
bam-5830	453	9	β	β	NOUN
bam-5830	453	10	phosphorylation	phosphorylation	NOUN
bam-5830	453	11	and	and	CCONJ
bam-5830	453	12	activation	activation	NOUN
bam-5830	453	13	during	during	ADP
bam-5830	453	14	myogenesis	myogenesis	NOUN
bam-5830	453	15	.	.	PUNCT
bam-5830	454	1	cdo	cdo	PROPN
bam-5830	454	2	,	,	PUNCT
bam-5830	454	3	a	a	DET
bam-5830	454	4	multifunctional	multifunctional	ADJ
bam-5830	454	5	surface	surface	NOUN
bam-5830	454	6	protein	protein	NOUN
bam-5830	454	7	has	have	AUX
bam-5830	454	8	been	be	AUX
bam-5830	454	9	implicated	implicate	VERB
bam-5830	454	10	in	in	ADP
bam-5830	454	11	myogenesis	myogenesis	NOUN
bam-5830	454	12	.	.	PUNCT
bam-5830	455	1	following	follow	VERB
bam-5830	455	2	celljtojcell	celljtojcell	NOUN
bam-5830	455	3	contact	contact	NOUN
bam-5830	455	4	and	and	CCONJ
bam-5830	455	5	ligation	ligation	NOUN
bam-5830	455	6	to	to	ADP
bam-5830	455	7	cadherin	cadherin	NOUN
bam-5830	455	8	,	,	PUNCT
bam-5830	455	9	cdo	cdo	PROPN
bam-5830	455	10	binds	bind	VERB
bam-5830	455	11	jlp	jlp	PROPN
bam-5830	455	12	and	and	CCONJ
bam-5830	455	13	bnipj2	bnipj2	PROPN
bam-5830	455	14	which	which	PRON
bam-5830	455	15	act	act	VERB
bam-5830	455	16	as	as	ADP
bam-5830	455	17	scaffolds	scaffold	NOUN
bam-5830	455	18	for	for	ADP
bam-5830	455	19	recruitment	recruitment	NOUN
bam-5830	455	20	of	of	ADP
bam-5830	455	21	p38α	p38α	PROPN
bam-5830	455	22	/	/	SYM
bam-5830	455	23	β	β	X
bam-5830	455	24	and	and	CCONJ
bam-5830	455	25	cdc42	cdc42	PROPN
bam-5830	455	26	.	.	PUNCT
bam-5830	456	1	the	the	DET
bam-5830	456	2	formation	formation	NOUN
bam-5830	456	3	of	of	ADP
bam-5830	456	4	the	the	DET
bam-5830	456	5	complex	complex	NOUN
bam-5830	456	6	leads	lead	VERB
bam-5830	456	7	to	to	ADP
bam-5830	456	8	activation	activation	NOUN
bam-5830	456	9	of	of	ADP
bam-5830	456	10	cdc42	cdc42	PROPN
bam-5830	456	11	,	,	PUNCT
bam-5830	456	12	which	which	PRON
bam-5830	456	13	is	be	AUX
bam-5830	456	14	fundamental	fundamental	ADJ
bam-5830	456	15	to	to	PART
bam-5830	456	16	promote	promote	VERB
bam-5830	456	17	p38α	p38α	PROPN
bam-5830	456	18	/	/	SYM
bam-5830	456	19	β	β	NOUN
bam-5830	456	20	phosphorylation	phosphorylation	NOUN
bam-5830	456	21	and	and	CCONJ
bam-5830	456	22	myogenic	myogenic	ADJ
bam-5830	456	23	differentiation	differentiation	NOUN
bam-5830	456	24	.	.	PUNCT
bam-5830	457	1	however	however	ADV
bam-5830	457	2	,	,	PUNCT
bam-5830	457	3	the	the	DET
bam-5830	457	4	phosphorylation	phosphorylation	NOUN
bam-5830	457	5	cascade	cascade	NOUN
bam-5830	457	6	leading	lead	VERB
bam-5830	457	7	to	to	ADP
bam-5830	457	8	p38α	p38α	PROPN
bam-5830	457	9	/	/	SYM
bam-5830	457	10	β	β	NOUN
bam-5830	457	11	activation	activation	NOUN
bam-5830	457	12	has	have	AUX
bam-5830	457	13	not	not	PART
bam-5830	457	14	been	be	AUX
bam-5830	457	15	elucidated	elucidate	VERB
bam-5830	457	16	.	.	PUNCT
bam-5830	458	1	we	we	PRON
bam-5830	458	2	focused	focus	VERB
bam-5830	458	3	on	on	ADP
bam-5830	458	4	pak1	pak1	PROPN
bam-5830	458	5	,	,	PUNCT
bam-5830	458	6	a	a	DET
bam-5830	458	7	member	member	NOUN
bam-5830	458	8	of	of	ADP
bam-5830	458	9	the	the	DET
bam-5830	458	10	p21	p21	NOUN
bam-5830	458	11	activated	activate	VERB
bam-5830	458	12	kinase	kinase	PROPN
bam-5830	458	13	family	family	PROPN
bam-5830	458	14	,	,	PUNCT
bam-5830	458	15	which	which	PRON
bam-5830	458	16	is	be	AUX
bam-5830	458	17	activated	activate	VERB
bam-5830	458	18	by	by	ADP
bam-5830	458	19	cdc42	cdc42	PROPN
bam-5830	458	20	.	.	PUNCT
bam-5830	459	1	we	we	PRON
bam-5830	459	2	have	have	AUX
bam-5830	459	3	observed	observe	VERB
bam-5830	459	4	that	that	SCONJ
bam-5830	459	5	treatment	treatment	NOUN
bam-5830	459	6	of	of	ADP
bam-5830	459	7	differentiating	differentiate	VERB
bam-5830	459	8	myogenic	myogenic	ADJ
bam-5830	459	9	progenitors	progenitor	NOUN
bam-5830	459	10	(	(	PUNCT
bam-5830	459	11	mesoangioblasts	mesoangioblast	NOUN
bam-5830	459	12	)	)	PUNCT
bam-5830	459	13	with	with	ADP
bam-5830	459	14	the	the	DET
bam-5830	459	15	pak1	pak1	PROPN
bam-5830	459	16	inhibitor	inhibitor	NOUN
bam-5830	459	17	ipaj3	ipaj3	PROPN
bam-5830	459	18	negatively	negatively	ADV
bam-5830	459	19	modulates	modulate	VERB
bam-5830	459	20	p38α	p38α	NOUN
bam-5830	459	21	/	/	SYM
bam-5830	459	22	β	β	NOUN
bam-5830	459	23	phosphorylation	phosphorylation	NOUN
bam-5830	459	24	and	and	CCONJ
bam-5830	459	25	myogenin	myogenin	ADJ
bam-5830	459	26	expression	expression	NOUN
bam-5830	459	27	without	without	ADP
bam-5830	459	28	affecting	affect	VERB
bam-5830	459	29	cell	cell	NOUN
bam-5830	459	30	proliferation	proliferation	NOUN
bam-5830	459	31	.	.	PUNCT
bam-5830	460	1	this	this	DET
bam-5830	460	2	inhibition	inhibition	NOUN
bam-5830	460	3	of	of	ADP
bam-5830	460	4	the	the	DET
bam-5830	460	5	myogenic	myogenic	ADJ
bam-5830	460	6	differentiation	differentiation	NOUN
bam-5830	460	7	program	program	NOUN
bam-5830	460	8	results	result	NOUN
bam-5830	460	9	in	in	ADP
bam-5830	460	10	a	a	DET
bam-5830	460	11	lower	low	ADJ
bam-5830	460	12	efficiency	efficiency	NOUN
bam-5830	460	13	of	of	ADP
bam-5830	460	14	myotube	myotube	NOUN
bam-5830	460	15	formation	formation	NOUN
bam-5830	460	16	.	.	PUNCT
bam-5830	461	1	we	we	PRON
bam-5830	461	2	followed	follow	VERB
bam-5830	461	3	these	these	DET
bam-5830	461	4	observations	observation	NOUN
bam-5830	461	5	in	in	ADP
bam-5830	461	6	vivo	vivo	NOUN
bam-5830	461	7	by	by	ADP
bam-5830	461	8	monitoring	monitor	VERB
bam-5830	461	9	regeneration	regeneration	NOUN
bam-5830	461	10	efficiency	efficiency	NOUN
bam-5830	461	11	in	in	ADP
bam-5830	461	12	mice	mouse	NOUN
bam-5830	461	13	treated	treat	VERB
bam-5830	461	14	with	with	ADP
bam-5830	461	15	ipa-3	ipa-3	PUNCT
bam-5830	461	16	and	and	CCONJ
bam-5830	461	17	we	we	PRON
bam-5830	461	18	observed	observe	VERB
bam-5830	461	19	that	that	SCONJ
bam-5830	461	20	mice	mouse	NOUN
bam-5830	461	21	treated	treat	VERB
bam-5830	461	22	with	with	ADP
bam-5830	461	23	ipa-3	ipa-3	PUNCT
bam-5830	461	24	displayed	display	VERB
bam-5830	461	25	a	a	DET
bam-5830	461	26	delayed	delay	VERB
bam-5830	461	27	recovery	recovery	NOUN
bam-5830	461	28	after	after	SCONJ
bam-5830	461	29	cardiotoxin	cardiotoxin	NOUN
bam-5830	461	30	injury	injury	NOUN
bam-5830	461	31	.	.	PUNCT
bam-5830	462	1	these	these	DET
bam-5830	462	2	results	result	NOUN
bam-5830	462	3	suggest	suggest	VERB
bam-5830	462	4	the	the	DET
bam-5830	462	5	pak1	pak1	NOUN
bam-5830	462	6	contributes	contribute	VERB
bam-5830	462	7	to	to	ADP
bam-5830	462	8	myogenic	myogenic	ADJ
bam-5830	462	9	differentiation	differentiation	NOUN
bam-5830	462	10	of	of	ADP
bam-5830	462	11	progenitor	progenitor	NOUN
bam-5830	462	12	cells	cell	NOUN
bam-5830	462	13	in	in	ADP
bam-5830	462	14	vitro	vitro	X
bam-5830	462	15	and	and	CCONJ
bam-5830	462	16	participates	participate	VERB
bam-5830	462	17	in	in	ADP
bam-5830	462	18	muscle	muscle	NOUN
bam-5830	462	19	regeneration	regeneration	NOUN
bam-5830	462	20	in	in	ADP
bam-5830	462	21	vivo	vivo	NOUN
bam-5830	462	22	.	.	PUNCT
bam-5830	463	1	*	*	PUNCT
bam-5830	463	2	*	*	PUNCT
bam-5830	463	3	*	*	PUNCT
bam-5830	463	4	*	*	PUNCT
bam-5830	463	5	*	*	VERB
bam-5830	463	6	abstracts	abstract	NOUN
bam-5830	463	7	of	of	ADP
bam-5830	463	8	the	the	DET
bam-5830	463	9	xii	xii	PROPN
bam-5830	463	10	iim	iim	NOUN
bam-5830	463	11	myology	myology	NOUN
bam-5830	463	12	meeting	meeting	NOUN
bam-5830	463	13	october	october	PROPN
bam-5830	463	14	1–4	1–4	PROPN
bam-5830	463	15	,	,	PUNCT
bam-5830	463	16	2015	2015	NUM
bam-5830	463	17	eur	eur	PROPN
bam-5830	463	18	j	j	PROPN
bam-5830	463	19	transl	transl	PROPN
bam-5830	463	20	myol	myol	PROPN
bam-5830	463	21	basic	basic	ADJ
bam-5830	463	22	appl	appl	NOUN
bam-5830	463	23	myol	myol	NOUN
bam-5830	463	24	2016	2016	NUM
bam-5830	463	25	;	;	PUNCT
bam-5830	463	26	26	26	NUM
bam-5830	463	27	(	(	PUNCT
bam-5830	463	28	1):2	1):2	NUM
bam-5830	463	29	-	-	SYM
bam-5830	463	30	24	24	NUM
bam-5830	463	31	this	this	DET
bam-5830	463	32	article	article	NOUN
bam-5830	463	33	is	be	AUX
bam-5830	463	34	distributed	distribute	VERB
bam-5830	463	35	under	under	ADP
bam-5830	463	36	the	the	DET
bam-5830	463	37	terms	term	NOUN
bam-5830	463	38	of	of	ADP
bam-5830	463	39	the	the	DET
bam-5830	463	40	creative	creative	ADJ
bam-5830	463	41	commons	common	NOUN
bam-5830	463	42	attribution	attribution	NOUN
bam-5830	463	43	noncommercial	noncommercial	ADJ
bam-5830	463	44	license	license	NOUN
bam-5830	463	45	(	(	PUNCT
bam-5830	463	46	cc	cc	NOUN
bam-5830	463	47	by	by	ADP
bam-5830	463	48	-	-	PUNCT
bam-5830	463	49	nc	nc	PROPN
bam-5830	463	50	4.0	4.0	NUM
bam-5830	463	51	)	)	PUNCT
bam-5830	463	52	which	which	PRON
bam-5830	463	53	permits	permit	VERB
bam-5830	463	54	any	any	DET
bam-5830	463	55	noncommercial	noncommercial	ADJ
bam-5830	463	56	use	use	NOUN
bam-5830	463	57	,	,	PUNCT
bam-5830	463	58	distribution	distribution	NOUN
bam-5830	463	59	,	,	PUNCT
bam-5830	463	60	and	and	CCONJ
bam-5830	463	61	reproduction	reproduction	NOUN
bam-5830	463	62	in	in	ADP
bam-5830	463	63	any	any	DET
bam-5830	463	64	medium	medium	NOUN
bam-5830	463	65	,	,	PUNCT
bam-5830	463	66	provided	provide	VERB
bam-5830	463	67	the	the	DET
bam-5830	463	68	original	original	ADJ
bam-5830	463	69	author(s	author(s	NOUN
bam-5830	463	70	)	)	PUNCT
bam-5830	463	71	and	and	CCONJ
bam-5830	463	72	source	source	NOUN
bam-5830	463	73	are	be	AUX
bam-5830	463	74	credited	credit	VERB
bam-5830	463	75	.	.	PUNCT
bam-5830	464	1	15	15	NUM
bam-5830	464	2	dissecting	dissect	VERB
bam-5830	464	3	the	the	DET
bam-5830	464	4	role	role	NOUN
bam-5830	464	5	of	of	ADP
bam-5830	464	6	ambra1	ambra1	PROPN
bam-5830	464	7	in	in	ADP
bam-5830	464	8	developing	develop	VERB
bam-5830	464	9	and	and	CCONJ
bam-5830	464	10	adult	adult	VERB
bam-5830	464	11	skeletal	skeletal	ADJ
bam-5830	464	12	muscle	muscle	NOUN
bam-5830	464	13	m.	m.	NOUN
bam-5830	464	14	chrisam	chrisam	PROPN
bam-5830	464	15	1	1	NUM
bam-5830	464	16	,	,	PUNCT
bam-5830	464	17	s.	s.	PROPN
bam-5830	464	18	castagnaro	castagnaro	VERB
bam-5830	464	19	1	1	NUM
bam-5830	464	20	,	,	PUNCT
bam-5830	464	21	m.	m.	NOUN
bam-5830	464	22	spizzotin	spizzotin	PROPN
bam-5830	464	23	1	1	NUM
bam-5830	464	24	,	,	PUNCT
bam-5830	464	25	p.	p.	NOUN
bam-5830	464	26	braghetta	braghetta	NOUN
bam-5830	465	1	1	1	NUM
bam-5830	465	2	,	,	PUNCT
bam-5830	465	3	p.	p.	NOUN
bam-5830	465	4	grumati	grumati	NOUN
bam-5830	465	5	1,2	1,2	NUM
bam-5830	465	6	,	,	PUNCT
bam-5830	465	7	f.	f.	PROPN
bam-5830	465	8	cecconi	cecconi	PROPN
bam-5830	465	9	3,4,5	3,4,5	NUM
bam-5830	465	10	,	,	PUNCT
bam-5830	465	11	p.	p.	NOUN
bam-5830	465	12	bonaldo	bonaldo	ADJ
bam-5830	466	1	1	1	NUM
bam-5830	466	2	1	1	NUM
bam-5830	466	3	.	.	PUNCT
bam-5830	466	4	department	department	NOUN
bam-5830	466	5	of	of	ADP
bam-5830	466	6	molecular	molecular	ADJ
bam-5830	466	7	medicine	medicine	NOUN
bam-5830	466	8	,	,	PUNCT
bam-5830	466	9	university	university	PROPN
bam-5830	466	10	of	of	ADP
bam-5830	466	11	padova	padova	PROPN
bam-5830	466	12	,	,	PUNCT
bam-5830	466	13	padova	padova	PROPN
bam-5830	466	14	,	,	PUNCT
bam-5830	466	15	italy	italy	PROPN
bam-5830	466	16	;	;	PUNCT
bam-5830	466	17	2	2	X
bam-5830	466	18	.	.	X
bam-5830	466	19	institute	institute	PROPN
bam-5830	466	20	of	of	ADP
bam-5830	466	21	biochemistry	biochemistry	PROPN
bam-5830	466	22	ii	ii	PROPN
bam-5830	466	23	,	,	PUNCT
bam-5830	466	24	goethe	goethe	PROPN
bam-5830	466	25	university	university	PROPN
bam-5830	466	26	,	,	PUNCT
bam-5830	466	27	frankfurt	frankfurt	PROPN
bam-5830	466	28	am	be	AUX
bam-5830	466	29	main	main	ADJ
bam-5830	466	30	,	,	PUNCT
bam-5830	466	31	germany	germany	NOUN
bam-5830	466	32	;	;	PUNCT
bam-5830	466	33	3	3	X
bam-5830	466	34	.	.	X
bam-5830	466	35	irccs	ircc	VERB
bam-5830	466	36	fondazione	fondazione	PROPN
bam-5830	466	37	santa	santa	PROPN
bam-5830	466	38	lucia	lucia	PROPN
bam-5830	466	39	,	,	PUNCT
bam-5830	466	40	rome	rome	PROPN
bam-5830	466	41	,	,	PUNCT
bam-5830	466	42	italy	italy	PROPN
bam-5830	466	43	;	;	PUNCT
bam-5830	466	44	4	4	X
bam-5830	466	45	.	.	X
bam-5830	466	46	department	department	NOUN
bam-5830	466	47	of	of	ADP
bam-5830	466	48	biology	biology	NOUN
bam-5830	466	49	,	,	PUNCT
bam-5830	466	50	university	university	NOUN
bam-5830	466	51	of	of	ADP
bam-5830	466	52	rome	rome	PROPN
bam-5830	466	53	tor	tor	PROPN
bam-5830	466	54	vergata	vergata	PROPN
bam-5830	466	55	,	,	PUNCT
bam-5830	466	56	italy	italy	PROPN
bam-5830	466	57	;	;	PUNCT
bam-5830	466	58	5	5	X
bam-5830	466	59	.	.	NOUN
bam-5830	466	60	danish	danish	PROPN
bam-5830	466	61	cancer	cancer	PROPN
bam-5830	466	62	society	society	PROPN
bam-5830	466	63	research	research	NOUN
bam-5830	466	64	center	center	PROPN
bam-5830	466	65	,	,	PUNCT
bam-5830	466	66	copenhagen	copenhagen	PROPN
bam-5830	466	67	,	,	PUNCT
bam-5830	466	68	denmark	denmark	NOUN
bam-5830	466	69	e	e	NOUN
bam-5830	466	70	-	-	NOUN
bam-5830	466	71	mail	mail	NOUN
bam-5830	466	72	:	:	PUNCT
bam-5830	466	73	martina.chrisam@studenti.unipd.it	martina.chrisam@studenti.unipd.it	NUM
bam-5830	466	74	ambra1	ambra1	PROPN
bam-5830	466	75	(	(	PUNCT
bam-5830	466	76	activating	activate	VERB
bam-5830	466	77	molecule	molecule	NOUN
bam-5830	466	78	in	in	ADP
bam-5830	466	79	beclin	beclin	NOUN
bam-5830	466	80	1	1	NUM
bam-5830	466	81	-	-	PUNCT
bam-5830	466	82	regulated	regulate	VERB
bam-5830	466	83	autophagy	autophagy	NOUN
bam-5830	466	84	)	)	PUNCT
bam-5830	466	85	is	be	AUX
bam-5830	466	86	an	an	DET
bam-5830	466	87	adaptor	adaptor	NOUN
bam-5830	466	88	protein	protein	NOUN
bam-5830	466	89	involved	involve	VERB
bam-5830	466	90	in	in	ADP
bam-5830	466	91	a	a	DET
bam-5830	466	92	plethora	plethora	NOUN
bam-5830	466	93	of	of	ADP
bam-5830	466	94	cellular	cellular	ADJ
bam-5830	466	95	processes	process	NOUN
bam-5830	466	96	.	.	PUNCT
bam-5830	467	1	studies	study	NOUN
bam-5830	467	2	in	in	ADP
bam-5830	467	3	mice	mouse	NOUN
bam-5830	467	4	with	with	ADP
bam-5830	467	5	a	a	DET
bam-5830	467	6	randomly	randomly	ADV
bam-5830	467	7	mutated	mutate	VERB
bam-5830	467	8	ambra1	ambra1	PROPN
bam-5830	467	9	locus	locus	NOUN
bam-5830	467	10	(	(	PUNCT
bam-5830	467	11	ambra1gt	ambra1gt	NOUN
bam-5830	467	12	/	/	SYM
bam-5830	467	13	gt	gt	PROPN
bam-5830	467	14	)	)	PUNCT
bam-5830	467	15	showed	show	VERB
bam-5830	467	16	that	that	SCONJ
bam-5830	467	17	this	this	DET
bam-5830	467	18	gene	gene	NOUN
bam-5830	467	19	is	be	AUX
bam-5830	467	20	essential	essential	ADJ
bam-5830	467	21	for	for	ADP
bam-5830	467	22	the	the	DET
bam-5830	467	23	development	development	NOUN
bam-5830	467	24	of	of	ADP
bam-5830	467	25	the	the	DET
bam-5830	467	26	central	central	ADJ
bam-5830	467	27	nervous	nervous	ADJ
bam-5830	467	28	system	system	NOUN
bam-5830	467	29	.	.	PUNCT
bam-5830	468	1	a	a	DET
bam-5830	468	2	recently	recently	ADV
bam-5830	468	3	published	publish	VERB
bam-5830	468	4	work	work	NOUN
bam-5830	468	5	by	by	ADP
bam-5830	468	6	our	our	PRON
bam-5830	468	7	team	team	NOUN
bam-5830	468	8	suggests	suggest	VERB
bam-5830	468	9	that	that	SCONJ
bam-5830	468	10	ambra1	ambra1	PROPN
bam-5830	468	11	may	may	AUX
bam-5830	468	12	also	also	ADV
bam-5830	468	13	play	play	VERB
bam-5830	468	14	a	a	DET
bam-5830	468	15	key	key	ADJ
bam-5830	468	16	role	role	NOUN
bam-5830	468	17	for	for	ADP
bam-5830	468	18	muscle	muscle	NOUN
bam-5830	468	19	development	development	NOUN
bam-5830	468	20	in	in	ADP
bam-5830	468	21	zebrafish	zebrafish	NUM
bam-5830	468	22	and	and	CCONJ
bam-5830	468	23	mouse	mouse	NOUN
bam-5830	468	24	.	.	PUNCT
bam-5830	469	1	indeed	indeed	ADV
bam-5830	469	2	,	,	PUNCT
bam-5830	469	3	ambra1gt	ambra1gt	PROPN
bam-5830	469	4	/	/	SYM
bam-5830	469	5	gt	gt	PROPN
bam-5830	469	6	e13.5	e13.5	PROPN
bam-5830	469	7	mouse	mouse	NOUN
bam-5830	469	8	embryos	embryo	NOUN
bam-5830	469	9	display	display	VERB
bam-5830	469	10	severe	severe	ADJ
bam-5830	469	11	defects	defect	NOUN
bam-5830	469	12	of	of	ADP
bam-5830	469	13	neck	neck	NOUN
bam-5830	469	14	,	,	PUNCT
bam-5830	469	15	tongue	tongue	NOUN
bam-5830	469	16	,	,	PUNCT
bam-5830	469	17	dorsal	dorsal	NOUN
bam-5830	469	18	and	and	CCONJ
bam-5830	469	19	limb	limb	NOUN
bam-5830	469	20	muscles	muscle	NOUN
bam-5830	469	21	,	,	PUNCT
bam-5830	469	22	being	be	AUX
bam-5830	469	23	characterized	characterize	VERB
bam-5830	469	24	by	by	ADP
bam-5830	469	25	increased	increase	VERB
bam-5830	469	26	cellularity	cellularity	NOUN
bam-5830	469	27	and	and	CCONJ
bam-5830	469	28	a	a	DET
bam-5830	469	29	marked	mark	VERB
bam-5830	469	30	disorganization	disorganization	NOUN
bam-5830	469	31	of	of	ADP
bam-5830	469	32	myofibers	myofiber	NOUN
bam-5830	469	33	.	.	PUNCT
bam-5830	470	1	to	to	PART
bam-5830	470	2	better	well	ADV
bam-5830	470	3	clarify	clarify	VERB
bam-5830	470	4	the	the	DET
bam-5830	470	5	role	role	NOUN
bam-5830	470	6	of	of	ADP
bam-5830	470	7	ambra1	ambra1	PROPN
bam-5830	470	8	in	in	ADP
bam-5830	470	9	skeletal	skeletal	ADJ
bam-5830	470	10	muscles	muscle	NOUN
bam-5830	470	11	,	,	PUNCT
bam-5830	470	12	we	we	PRON
bam-5830	470	13	generated	generate	VERB
bam-5830	470	14	mice	mouse	NOUN
bam-5830	470	15	with	with	ADP
bam-5830	470	16	a	a	DET
bam-5830	470	17	floxed	floxed	ADJ
bam-5830	470	18	ambra1	ambra1	PROPN
bam-5830	470	19	allele	allele	NOUN
bam-5830	470	20	(	(	PUNCT
bam-5830	470	21	ambra1flox	ambra1flox	PROPN
bam-5830	470	22	/	/	SYM
bam-5830	470	23	flox	flox	PROPN
bam-5830	470	24	)	)	PUNCT
bam-5830	470	25	.	.	PUNCT
bam-5830	471	1	ambra1flox	ambra1flox	PROPN
bam-5830	471	2	/	/	SYM
bam-5830	472	1	flox	flox	PROPN
bam-5830	472	2	mice	mouse	NOUN
bam-5830	472	3	were	be	AUX
bam-5830	472	4	then	then	ADV
bam-5830	472	5	crossed	cross	VERB
bam-5830	472	6	with	with	ADP
bam-5830	472	7	a	a	DET
bam-5830	472	8	cag	cag	PROPN
bam-5830	472	9	-	-	PUNCT
bam-5830	472	10	cre	cre	PROPN
bam-5830	472	11	transgenic	transgenic	NOUN
bam-5830	472	12	line	line	NOUN
bam-5830	472	13	,	,	PUNCT
bam-5830	472	14	which	which	PRON
bam-5830	472	15	express	express	VERB
bam-5830	472	16	cre	cre	PROPN
bam-5830	472	17	recombinase	recombinase	NOUN
bam-5830	472	18	in	in	ADP
bam-5830	472	19	the	the	DET
bam-5830	472	20	oocytes	oocyte	NOUN
bam-5830	472	21	,	,	PUNCT
bam-5830	472	22	thus	thus	ADV
bam-5830	472	23	obtaining	obtain	VERB
bam-5830	472	24	ambra1+/−	ambra1+/−	PRON
bam-5830	472	25	mice	mouse	NOUN
bam-5830	472	26	.	.	PUNCT
bam-5830	473	1	here	here	ADV
bam-5830	473	2	we	we	PRON
bam-5830	473	3	show	show	VERB
bam-5830	473	4	that	that	SCONJ
bam-5830	473	5	ambra1−/−	ambra1−/−	ADJ
bam-5830	473	6	mice	mouse	NOUN
bam-5830	473	7	die	die	VERB
bam-5830	473	8	at	at	ADP
bam-5830	473	9	late	late	ADJ
bam-5830	473	10	developmental	developmental	ADJ
bam-5830	473	11	stages	stage	NOUN
bam-5830	473	12	and	and	CCONJ
bam-5830	473	13	display	display	VERB
bam-5830	473	14	severe	severe	ADJ
bam-5830	473	15	morphological	morphological	ADJ
bam-5830	473	16	defects	defect	NOUN
bam-5830	473	17	,	,	PUNCT
bam-5830	473	18	similar	similar	ADJ
bam-5830	473	19	to	to	ADP
bam-5830	473	20	ambra1gt	ambra1gt	NOUN
bam-5830	473	21	/	/	SYM
bam-5830	473	22	gt	gt	PROPN
bam-5830	473	23	embryos	embryo	NOUN
bam-5830	473	24	.	.	PUNCT
bam-5830	474	1	adult	adult	NOUN
bam-5830	474	2	ambra1+/−	ambra1+/−	NOUN
bam-5830	474	3	mice	mouse	NOUN
bam-5830	474	4	show	show	VERB
bam-5830	474	5	an	an	DET
bam-5830	474	6	increased	increased	ADJ
bam-5830	474	7	percentage	percentage	NOUN
bam-5830	474	8	of	of	ADP
bam-5830	474	9	centrally	centrally	ADV
bam-5830	474	10	nucleated	nucleated	ADJ
bam-5830	474	11	fibers	fiber	NOUN
bam-5830	474	12	and	and	CCONJ
bam-5830	474	13	a	a	DET
bam-5830	474	14	decreased	decrease	VERB
bam-5830	474	15	proportion	proportion	NOUN
bam-5830	474	16	of	of	ADP
bam-5830	474	17	oxidative	oxidative	ADJ
bam-5830	474	18	fibers	fiber	NOUN
bam-5830	474	19	.	.	PUNCT
bam-5830	475	1	ambra1flox	ambra1flox	PROPN
bam-5830	475	2	/	/	SYM
bam-5830	476	1	flox	flox	PROPN
bam-5830	476	2	mice	mouse	NOUN
bam-5830	476	3	were	be	AUX
bam-5830	476	4	then	then	ADV
bam-5830	476	5	bred	breed	VERB
bam-5830	476	6	with	with	ADP
bam-5830	476	7	mlc-1f	mlc-1f	NOUN
bam-5830	476	8	-	-	PUNCT
bam-5830	476	9	cre	cre	NOUN
bam-5830	476	10	transgenic	transgenic	NOUN
bam-5830	476	11	animals	animal	NOUN
bam-5830	476	12	,	,	PUNCT
bam-5830	476	13	which	which	PRON
bam-5830	476	14	only	only	ADV
bam-5830	476	15	express	express	VERB
bam-5830	476	16	cre	cre	PROPN
bam-5830	476	17	recombinase	recombinase	NOUN
bam-5830	476	18	in	in	ADP
bam-5830	476	19	mature	mature	ADJ
bam-5830	476	20	myofibers	myofiber	NOUN
bam-5830	476	21	.	.	PUNCT
bam-5830	477	1	our	our	PRON
bam-5830	477	2	preliminary	preliminary	ADJ
bam-5830	477	3	data	datum	NOUN
bam-5830	477	4	in	in	ADP
bam-5830	477	5	adult	adult	NOUN
bam-5830	477	6	ambra1flox	ambra1flox	NOUN
bam-5830	477	7	/	/	SYM
bam-5830	477	8	flox;mlc-1f	flox;mlc-1f	NOUN
bam-5830	477	9	-	-	PUNCT
bam-5830	477	10	cre	cre	NOUN
bam-5830	477	11	mice	mouse	NOUN
bam-5830	477	12	show	show	VERB
bam-5830	477	13	a	a	DET
bam-5830	477	14	significant	significant	ADJ
bam-5830	477	15	increase	increase	NOUN
bam-5830	477	16	of	of	ADP
bam-5830	477	17	centrally	centrally	ADV
bam-5830	477	18	nucleated	nucleated	ADJ
bam-5830	477	19	fibers	fiber	NOUN
bam-5830	477	20	,	,	PUNCT
bam-5830	477	21	although	although	SCONJ
bam-5830	477	22	we	we	PRON
bam-5830	477	23	did	do	AUX
bam-5830	477	24	not	not	PART
bam-5830	477	25	observe	observe	VERB
bam-5830	477	26	any	any	DET
bam-5830	477	27	overt	overt	ADJ
bam-5830	477	28	defect	defect	NOUN
bam-5830	477	29	of	of	ADP
bam-5830	477	30	oxidative	oxidative	ADJ
bam-5830	477	31	fibers	fiber	NOUN
bam-5830	477	32	.	.	PUNCT
bam-5830	478	1	altogether	altogether	ADV
bam-5830	478	2	,	,	PUNCT
bam-5830	478	3	our	our	PRON
bam-5830	478	4	data	datum	NOUN
bam-5830	478	5	suggest	suggest	VERB
bam-5830	478	6	that	that	SCONJ
bam-5830	478	7	ambra1	ambra1	PROPN
bam-5830	478	8	is	be	AUX
bam-5830	478	9	important	important	ADJ
bam-5830	478	10	for	for	ADP
bam-5830	478	11	the	the	DET
bam-5830	478	12	development	development	NOUN
bam-5830	478	13	of	of	ADP
bam-5830	478	14	skeletal	skeletal	ADJ
bam-5830	478	15	muscle	muscle	NOUN
bam-5830	478	16	.	.	PUNCT
bam-5830	479	1	further	further	ADJ
bam-5830	479	2	studies	study	NOUN
bam-5830	479	3	in	in	ADP
bam-5830	479	4	different	different	ADJ
bam-5830	479	5	muscles	muscle	NOUN
bam-5830	479	6	of	of	ADP
bam-5830	479	7	ambra1flox	ambra1flox	PROPN
bam-5830	479	8	/	/	SYM
bam-5830	479	9	flox;mlc-1f	flox;mlc-1f	NOUN
bam-5830	479	10	-	-	PUNCT
bam-5830	479	11	cre	cre	NOUN
bam-5830	479	12	mice	mouse	NOUN
bam-5830	479	13	under	under	ADP
bam-5830	479	14	different	different	ADJ
bam-5830	479	15	stress	stress	NOUN
bam-5830	479	16	conditions	condition	NOUN
bam-5830	479	17	will	will	AUX
bam-5830	479	18	allow	allow	VERB
bam-5830	479	19	elucidating	elucidate	VERB
bam-5830	479	20	the	the	DET
bam-5830	479	21	role	role	NOUN
bam-5830	479	22	of	of	ADP
bam-5830	479	23	this	this	DET
bam-5830	479	24	adaptor	adaptor	NOUN
bam-5830	479	25	protein	protein	NOUN
bam-5830	479	26	in	in	ADP
bam-5830	479	27	myofiber	myofiber	ADJ
bam-5830	479	28	homeostasis	homeostasis	NOUN
bam-5830	479	29	*	*	PUNCT
bam-5830	479	30	*	*	PUNCT
bam-5830	479	31	*	*	PUNCT
bam-5830	479	32	*	*	PUNCT
bam-5830	479	33	*	*	PUNCT
bam-5830	479	34	the	the	DET
bam-5830	479	35	role	role	NOUN
bam-5830	479	36	of	of	ADP
bam-5830	479	37	myopalladin	myopalladin	VERB
bam-5830	479	38	in	in	ADP
bam-5830	479	39	skeletal	skeletal	ADJ
bam-5830	479	40	muscle	muscle	NOUN
bam-5830	479	41	growth	growth	PROPN
bam-5830	479	42	m.c	m.c	PROPN
bam-5830	479	43	.	.	PROPN
bam-5830	479	44	filomena	filomena	PROPN
bam-5830	479	45	1,2	1,2	NUM
bam-5830	479	46	,	,	PUNCT
bam-5830	479	47	d.l	d.l	PROPN
bam-5830	479	48	.	.	PROPN
bam-5830	479	49	yamamoto	yamamoto	PROPN
bam-5830	479	50	3,5	3,5	NUM
bam-5830	479	51	,	,	PUNCT
bam-5830	479	52	g.	g.	PROPN
bam-5830	479	53	mastrototaro	mastrototaro	PROPN
bam-5830	479	54	3,6	3,6	NUM
bam-5830	479	55	,	,	PUNCT
bam-5830	479	56	p.	p.	NOUN
bam-5830	479	57	carullo	carullo	PROPN
bam-5830	479	58	2,4	2,4	NUM
bam-5830	479	59	,	,	PUNCT
bam-5830	479	60	m.	m.	NOUN
bam-5830	479	61	caremani	caremani	NOUN
bam-5830	479	62	7	7	NUM
bam-5830	479	63	,	,	PUNCT
bam-5830	479	64	r.	r.	PROPN
bam-5830	479	65	lieber	lieber	PROPN
bam-5830	479	66	8	8	NUM
bam-5830	479	67	,	,	PUNCT
bam-5830	479	68	v.	v.	ADP
bam-5830	479	69	nigro	nigro	ADJ
bam-5830	479	70	9,10	9,10	PROPN
bam-5830	479	71	,	,	PUNCT
bam-5830	479	72	m.	m.	NOUN
bam-5830	479	73	linari	linari	PROPN
bam-5830	479	74	7	7	NUM
bam-5830	479	75	,	,	PUNCT
bam-5830	479	76	j.	j.	PROPN
bam-5830	479	77	chen	chen	PROPN
bam-5830	479	78	8	8	PROPN
bam-5830	479	79	,	,	PUNCT
bam-5830	479	80	m.l	m.l	PROPN
bam-5830	479	81	bang	bang	NOUN
bam-5830	479	82	2,4	2,4	NUM
bam-5830	479	83	1	1	NUM
bam-5830	479	84	.	.	PUNCT
bam-5830	480	1	department	department	NOUN
bam-5830	480	2	of	of	ADP
bam-5830	480	3	medical	medical	ADJ
bam-5830	480	4	biotechnologies	biotechnology	NOUN
bam-5830	480	5	and	and	CCONJ
bam-5830	480	6	translational	translational	ADJ
bam-5830	480	7	medicine	medicine	NOUN
bam-5830	480	8	,	,	PUNCT
bam-5830	480	9	university	university	PROPN
bam-5830	480	10	of	of	ADP
bam-5830	480	11	milan	milan	PROPN
bam-5830	480	12	;	;	PUNCT
bam-5830	480	13	2	2	X
bam-5830	480	14	.	.	X
bam-5830	480	15	humanitas	humanitas	PROPN
bam-5830	480	16	research	research	PROPN
bam-5830	480	17	hospital	hospital	NOUN
bam-5830	480	18	,	,	PUNCT
bam-5830	480	19	rozzano	rozzano	PROPN
bam-5830	480	20	,	,	PUNCT
bam-5830	480	21	milan	milan	PROPN
bam-5830	480	22	;	;	PUNCT
bam-5830	480	23	3	3	X
bam-5830	480	24	.	.	X
bam-5830	480	25	institute	institute	PROPN
bam-5830	480	26	of	of	ADP
bam-5830	480	27	biomedical	biomedical	ADJ
bam-5830	480	28	technologies	technology	NOUN
bam-5830	480	29	and	and	CCONJ
bam-5830	480	30	4	4	NUM
bam-5830	480	31	.	.	X
bam-5830	480	32	institute	institute	PROPN
bam-5830	480	33	of	of	ADP
bam-5830	480	34	genetic	genetic	ADJ
bam-5830	480	35	and	and	CCONJ
bam-5830	480	36	biomedical	biomedical	ADJ
bam-5830	480	37	research	research	NOUN
bam-5830	480	38	,	,	PUNCT
bam-5830	480	39	milan	milan	PROPN
bam-5830	480	40	unit	unit	PROPN
bam-5830	480	41	,	,	PUNCT
bam-5830	480	42	cnr	cnr	PROPN
bam-5830	480	43	,	,	PUNCT
bam-5830	480	44	milan	milan	PROPN
bam-5830	480	45	;	;	PUNCT
bam-5830	480	46	5	5	NUM
bam-5830	480	47	.	.	NOUN
bam-5830	480	48	multimedica	multimedica	PROPN
bam-5830	480	49	hospital	hospital	NOUN
bam-5830	480	50	,	,	PUNCT
bam-5830	480	51	scientific	scientific	ADJ
bam-5830	480	52	and	and	CCONJ
bam-5830	480	53	technology	technology	NOUN
bam-5830	480	54	pole	pole	NOUN
bam-5830	480	55	,	,	PUNCT
bam-5830	480	56	milan	milan	PROPN
bam-5830	480	57	;	;	PUNCT
bam-5830	480	58	6	6	NUM
bam-5830	480	59	.	.	PUNCT
bam-5830	480	60	doctoral	doctoral	ADJ
bam-5830	480	61	school	school	NOUN
bam-5830	480	62	in	in	ADP
bam-5830	480	63	molecular	molecular	ADJ
bam-5830	480	64	and	and	CCONJ
bam-5830	480	65	translational	translational	ADJ
bam-5830	480	66	medicine	medicine	NOUN
bam-5830	480	67	,	,	PUNCT
bam-5830	480	68	university	university	NOUN
bam-5830	480	69	of	of	ADP
bam-5830	480	70	milanobicocca	milanobicocca	PROPN
bam-5830	480	71	,	,	PUNCT
bam-5830	480	72	milan	milan	PROPN
bam-5830	480	73	;	;	PUNCT
bam-5830	480	74	7	7	X
bam-5830	480	75	.	.	X
bam-5830	480	76	department	department	NOUN
bam-5830	480	77	of	of	ADP
bam-5830	480	78	biological	biological	ADJ
bam-5830	480	79	evolution	evolution	NOUN
bam-5830	480	80	,	,	PUNCT
bam-5830	480	81	university	university	NOUN
bam-5830	480	82	of	of	ADP
bam-5830	480	83	florence	florence	NOUN
bam-5830	480	84	,	,	PUNCT
bam-5830	480	85	italy	italy	PROPN
bam-5830	480	86	;	;	PUNCT
bam-5830	480	87	8	8	X
bam-5830	480	88	.	.	X
bam-5830	480	89	department	department	NOUN
bam-5830	480	90	of	of	ADP
bam-5830	480	91	medicine	medicine	NOUN
bam-5830	480	92	,	,	PUNCT
bam-5830	480	93	university	university	PROPN
bam-5830	480	94	of	of	ADP
bam-5830	480	95	california	california	PROPN
bam-5830	480	96	san	san	PROPN
bam-5830	480	97	diego	diego	PROPN
bam-5830	480	98	,	,	PUNCT
bam-5830	480	99	usa	usa	PROPN
bam-5830	480	100	;	;	PUNCT
bam-5830	480	101	9	9	NUM
bam-5830	480	102	.	.	X
bam-5830	480	103	department	department	PROPN
bam-5830	480	104	of	of	ADP
bam-5830	480	105	general	general	ADJ
bam-5830	480	106	pathology	pathology	PROPN
bam-5830	480	107	,	,	PUNCT
bam-5830	480	108	second	second	ADJ
bam-5830	480	109	university	university	PROPN
bam-5830	480	110	of	of	ADP
bam-5830	480	111	naples	naples	PROPN
bam-5830	480	112	;	;	PUNCT
bam-5830	480	113	10	10	NUM
bam-5830	480	114	.	.	PUNCT
bam-5830	481	1	telethon	telethon	PROPN
bam-5830	481	2	institute	institute	PROPN
bam-5830	481	3	of	of	ADP
bam-5830	481	4	genetics	genetic	NOUN
bam-5830	481	5	and	and	CCONJ
bam-5830	481	6	medicine	medicine	NOUN
bam-5830	481	7	,	,	PUNCT
bam-5830	481	8	naples	naples	PROPN
bam-5830	481	9	,	,	PUNCT
bam-5830	481	10	italy	italy	PROPN
bam-5830	481	11	e	e	PROPN
bam-5830	481	12	-	-	NOUN
bam-5830	481	13	mail	mail	NOUN
bam-5830	481	14	:	:	PUNCT
bam-5830	481	15	maria_carmela.filomena@humanitasresearch.it	maria_carmela.filomena@humanitasresearch.it	PRON
bam-5830	481	16	myopalladin	myopalladin	NOUN
bam-5830	481	17	(	(	PUNCT
bam-5830	481	18	mypn	mypn	PROPN
bam-5830	481	19	)	)	PUNCT
bam-5830	481	20	is	be	AUX
bam-5830	481	21	a	a	DET
bam-5830	481	22	striated	striated	ADJ
bam-5830	481	23	muscle	muscle	NOUN
bam-5830	481	24	-	-	PUNCT
bam-5830	481	25	specific	specific	ADJ
bam-5830	481	26	sarcomeric	sarcomeric	ADJ
bam-5830	481	27	protein	protein	NOUN
bam-5830	481	28	belonging	belong	VERB
bam-5830	481	29	to	to	ADP
bam-5830	481	30	a	a	DET
bam-5830	481	31	small	small	ADJ
bam-5830	481	32	family	family	NOUN
bam-5830	481	33	of	of	ADP
bam-5830	481	34	actinassociated	actinassociate	VERB
bam-5830	481	35	immunoglobulin	immunoglobulin	NOUN
bam-5830	481	36	-	-	PUNCT
bam-5830	481	37	containing	contain	VERB
bam-5830	481	38	proteins	protein	NOUN
bam-5830	481	39	.	.	PUNCT
bam-5830	482	1	mypn	mypn	NOUN
bam-5830	482	2	mutations	mutation	NOUN
bam-5830	482	3	have	have	AUX
bam-5830	482	4	been	be	AUX
bam-5830	482	5	identified	identify	VERB
bam-5830	482	6	in	in	ADP
bam-5830	482	7	patients	patient	NOUN
bam-5830	482	8	with	with	ADP
bam-5830	482	9	dilated	dilated	ADJ
bam-5830	482	10	(	(	PUNCT
bam-5830	482	11	dcm	dcm	NOUN
bam-5830	482	12	)	)	PUNCT
bam-5830	482	13	,	,	PUNCT
bam-5830	482	14	hypertrophic	hypertrophic	ADJ
bam-5830	482	15	,	,	PUNCT
bam-5830	482	16	and	and	CCONJ
bam-5830	482	17	restrictive	restrictive	ADJ
bam-5830	482	18	cardiomyopathy	cardiomyopathy	ADJ
bam-5830	482	19	.	.	PUNCT
bam-5830	483	1	furthermore	furthermore	ADV
bam-5830	483	2	,	,	PUNCT
bam-5830	483	3	we	we	PRON
bam-5830	483	4	identified	identify	VERB
bam-5830	483	5	three	three	NUM
bam-5830	483	6	mypn	mypn	NOUN
bam-5830	483	7	mutations	mutation	NOUN
bam-5830	483	8	in	in	ADP
bam-5830	483	9	limb	limb	NOUN
bam-5830	483	10	girdle	girdle	NOUN
bam-5830	483	11	muscular	muscular	ADJ
bam-5830	483	12	dystrophy	dystrophy	NOUN
bam-5830	483	13	(	(	PUNCT
bam-5830	483	14	lgmd	lgmd	NOUN
bam-5830	483	15	)	)	PUNCT
bam-5830	483	16	patients	patient	NOUN
bam-5830	483	17	with	with	ADP
bam-5830	483	18	associated	associated	ADJ
bam-5830	483	19	dcm	dcm	PROPN
bam-5830	483	20	.	.	PUNCT
bam-5830	484	1	within	within	ADP
bam-5830	484	2	the	the	DET
bam-5830	484	3	sarcomeric	sarcomeric	ADJ
bam-5830	484	4	z	z	NOUN
bam-5830	484	5	-	-	NOUN
bam-5830	484	6	line	line	NOUN
bam-5830	484	7	,	,	PUNCT
bam-5830	484	8	myopalladin	myopalladin	NOUN
bam-5830	484	9	binds	bind	VERB
bam-5830	484	10	to	to	ADP
bam-5830	484	11	αactinin	αactinin	NOUN
bam-5830	484	12	,	,	PUNCT
bam-5830	484	13	nebulin	nebulin	PROPN
bam-5830	484	14	,	,	PUNCT
bam-5830	484	15	and	and	CCONJ
bam-5830	484	16	pdz	pdz	NOUN
bam-5830	484	17	-	-	PUNCT
bam-5830	484	18	lim	lim	NOUN
bam-5830	484	19	proteins	protein	NOUN
bam-5830	484	20	.	.	PUNCT
bam-5830	485	1	furthermore	furthermore	ADV
bam-5830	485	2	,	,	PUNCT
bam-5830	485	3	it	it	PRON
bam-5830	485	4	is	be	AUX
bam-5830	485	5	present	present	ADJ
bam-5830	485	6	in	in	ADP
bam-5830	485	7	the	the	DET
bam-5830	485	8	nucleus	nucleus	NOUN
bam-5830	485	9	and	and	CCONJ
bam-5830	485	10	the	the	DET
bam-5830	485	11	i	i	NOUN
bam-5830	485	12	-	-	NOUN
bam-5830	485	13	band	band	NOUN
bam-5830	485	14	where	where	SCONJ
bam-5830	485	15	it	it	PRON
bam-5830	485	16	binds	bind	VERB
bam-5830	485	17	to	to	ADP
bam-5830	485	18	the	the	DET
bam-5830	485	19	stress	stress	NOUN
bam-5830	485	20	-	-	PUNCT
bam-5830	485	21	inducible	inducible	ADJ
bam-5830	485	22	transcriptional	transcriptional	ADJ
bam-5830	485	23	cofactor	cofactor	NOUN
bam-5830	485	24	carp	carp	NOUN
bam-5830	485	25	/	/	SYM
bam-5830	485	26	ankrd1	ankrd1	NOUN
bam-5830	485	27	,	,	PUNCT
bam-5830	485	28	which	which	PRON
bam-5830	485	29	,	,	PUNCT
bam-5830	485	30	in	in	ADP
bam-5830	485	31	turn	turn	NOUN
bam-5830	485	32	,	,	PUNCT
bam-5830	485	33	binds	bind	VERB
bam-5830	485	34	to	to	ADP
bam-5830	485	35	the	the	DET
bam-5830	485	36	i	i	PROPN
bam-5830	485	37	-	-	PUNCT
bam-5830	485	38	band	band	NOUN
bam-5830	485	39	region	region	NOUN
bam-5830	485	40	of	of	ADP
bam-5830	485	41	titin	titin	PROPN
bam-5830	485	42	,	,	PUNCT
bam-5830	485	43	suggesting	suggest	VERB
bam-5830	485	44	a	a	DET
bam-5830	485	45	role	role	NOUN
bam-5830	485	46	of	of	ADP
bam-5830	485	47	mypn	mypn	NOUN
bam-5830	485	48	in	in	ADP
bam-5830	485	49	mechanosensing	mechanosense	VERB
bam-5830	485	50	.	.	PUNCT
bam-5830	486	1	in	in	ADP
bam-5830	486	2	our	our	PRON
bam-5830	486	3	preliminary	preliminary	ADJ
bam-5830	486	4	studies	study	NOUN
bam-5830	486	5	,	,	PUNCT
bam-5830	486	6	we	we	PRON
bam-5830	486	7	found	find	VERB
bam-5830	486	8	that	that	SCONJ
bam-5830	486	9	mypn	mypn	PROPN
bam-5830	486	10	can	can	AUX
bam-5830	486	11	bind	bind	VERB
bam-5830	486	12	to	to	ADP
bam-5830	486	13	and	and	CCONJ
bam-5830	486	14	bundle	bundle	VERB
bam-5830	486	15	filamentous	filamentous	ADJ
bam-5830	486	16	actin	actin	NOUN
bam-5830	486	17	,	,	PUNCT
bam-5830	486	18	thereby	thereby	ADV
bam-5830	486	19	promoting	promote	VERB
bam-5830	486	20	actin	actin	NOUN
bam-5830	486	21	polymerization	polymerization	NOUN
bam-5830	486	22	.	.	PUNCT
bam-5830	487	1	moreover	moreover	ADV
bam-5830	487	2	,	,	PUNCT
bam-5830	487	3	mypn	mypn	PROPN
bam-5830	487	4	interacts	interact	VERB
bam-5830	487	5	with	with	ADP
bam-5830	487	6	mrtf	mrtf	NOUN
bam-5830	487	7	-	-	PUNCT
bam-5830	487	8	a	a	NOUN
bam-5830	487	9	and	and	CCONJ
bam-5830	487	10	strongly	strongly	ADV
bam-5830	487	11	increases	increase	VERB
bam-5830	487	12	mrtf	mrtf	ADJ
bam-5830	487	13	-	-	PUNCT
bam-5830	487	14	a	a	PRON
bam-5830	487	15	-	-	PUNCT
bam-5830	487	16	mediated	mediate	VERB
bam-5830	487	17	activation	activation	NOUN
bam-5830	487	18	of	of	ADP
bam-5830	487	19	serum	serum	NOUN
bam-5830	487	20	response	response	NOUN
bam-5830	487	21	factor	factor	NOUN
bam-5830	487	22	(	(	PUNCT
bam-5830	487	23	srf	srf	NOUN
bam-5830	487	24	)	)	PUNCT
bam-5830	487	25	signaling	signal	VERB
bam-5830	487	26	.	.	PUNCT
bam-5830	488	1	in	in	ADP
bam-5830	488	2	studies	study	NOUN
bam-5830	488	3	of	of	ADP
bam-5830	488	4	mypn	mypn	PROPN
bam-5830	488	5	knockout	knockout	PROPN
bam-5830	488	6	(	(	PUNCT
bam-5830	488	7	mko	mko	PROPN
bam-5830	488	8	)	)	PUNCT
bam-5830	488	9	mice	mouse	NOUN
bam-5830	488	10	,	,	PUNCT
bam-5830	488	11	we	we	PRON
bam-5830	488	12	found	find	VERB
bam-5830	488	13	that	that	SCONJ
bam-5830	488	14	mko	mko	PROPN
bam-5830	488	15	mice	mouse	NOUN
bam-5830	488	16	are	be	AUX
bam-5830	488	17	significantly	significantly	ADV
bam-5830	488	18	smaller	small	ADJ
bam-5830	488	19	compared	compare	VERB
bam-5830	488	20	to	to	ADP
bam-5830	488	21	wildtype	wildtype	NOUN
bam-5830	488	22	(	(	PUNCT
bam-5830	488	23	wt	wt	NOUN
bam-5830	488	24	)	)	PUNCT
bam-5830	488	25	mice	mouse	NOUN
bam-5830	488	26	and	and	CCONJ
bam-5830	488	27	have	have	VERB
bam-5830	488	28	an	an	DET
bam-5830	488	29	about	about	ADP
bam-5830	488	30	30	30	NUM
bam-5830	488	31	%	%	NOUN
bam-5830	488	32	reduction	reduction	NOUN
bam-5830	488	33	in	in	ADP
bam-5830	488	34	skeletal	skeletal	ADJ
bam-5830	488	35	muscle	muscle	NOUN
bam-5830	488	36	cross	cross	ADJ
bam-5830	488	37	-	-	ADJ
bam-5830	488	38	sectional	sectional	ADJ
bam-5830	488	39	area	area	NOUN
bam-5830	488	40	(	(	PUNCT
bam-5830	488	41	csa	csa	PROPN
bam-5830	488	42	)	)	PUNCT
bam-5830	488	43	at	at	ADP
bam-5830	488	44	all	all	DET
bam-5830	488	45	ages	age	NOUN
bam-5830	488	46	.	.	PUNCT
bam-5830	489	1	consistently	consistently	ADV
bam-5830	489	2	,	,	PUNCT
bam-5830	489	3	reduced	reduce	VERB
bam-5830	489	4	differentiation	differentiation	NOUN
bam-5830	489	5	rate	rate	NOUN
bam-5830	489	6	and	and	CCONJ
bam-5830	489	7	myotube	myotube	NOUN
bam-5830	489	8	width	width	NOUN
bam-5830	489	9	was	be	AUX
bam-5830	489	10	observed	observe	VERB
bam-5830	489	11	in	in	ADP
bam-5830	489	12	primary	primary	ADJ
bam-5830	489	13	skeletal	skeletal	ADJ
bam-5830	489	14	muscle	muscle	NOUN
bam-5830	489	15	cultures	culture	NOUN
bam-5830	489	16	derived	derive	VERB
bam-5830	489	17	from	from	ADP
bam-5830	489	18	mko	mko	PROPN
bam-5830	489	19	mice	mouse	NOUN
bam-5830	489	20	.	.	PUNCT
bam-5830	490	1	furthermore	furthermore	ADV
bam-5830	490	2	,	,	PUNCT
bam-5830	490	3	studies	study	NOUN
bam-5830	490	4	of	of	ADP
bam-5830	490	5	muscle	muscle	NOUN
bam-5830	490	6	performance	performance	NOUN
bam-5830	490	7	in	in	ADP
bam-5830	490	8	2	2	NUM
bam-5830	490	9	-	-	PUNCT
bam-5830	490	10	month	month	NOUN
bam-5830	490	11	-	-	PUNCT
bam-5830	490	12	old	old	ADJ
bam-5830	490	13	mko	mko	NOUN
bam-5830	490	14	mice	mouse	NOUN
bam-5830	490	15	showed	show	VERB
bam-5830	490	16	reduced	reduce	VERB
bam-5830	490	17	isometric	isometric	ADJ
bam-5830	490	18	force	force	NOUN
bam-5830	490	19	and	and	CCONJ
bam-5830	490	20	power	power	NOUN
bam-5830	490	21	during	during	ADP
bam-5830	490	22	isotonic	isotonic	ADJ
bam-5830	490	23	shortening	shortening	NOUN
bam-5830	490	24	at	at	ADP
bam-5830	490	25	any	any	DET
bam-5830	490	26	loads	load	NOUN
bam-5830	490	27	as	as	ADP
bam-5830	490	28	a	a	DET
bam-5830	490	29	result	result	NOUN
bam-5830	490	30	of	of	ADP
bam-5830	490	31	the	the	DET
bam-5830	490	32	reduced	reduce	VERB
bam-5830	490	33	cross	cross	PROPN
bam-5830	490	34	sectional	sectional	ADJ
bam-5830	490	35	area	area	NOUN
bam-5830	490	36	,	,	PUNCT
bam-5830	490	37	whereas	whereas	SCONJ
bam-5830	490	38	the	the	DET
bam-5830	490	39	force	force	NOUN
bam-5830	490	40	developed	develop	VERB
bam-5830	490	41	by	by	ADP
bam-5830	490	42	each	each	DET
bam-5830	490	43	myosin	myosin	PROPN
bam-5830	490	44	molecular	molecular	ADJ
bam-5830	490	45	motor	motor	NOUN
bam-5830	490	46	was	be	AUX
bam-5830	490	47	unaffected	unaffected	ADJ
bam-5830	490	48	.	.	PUNCT
bam-5830	491	1	by	by	ADP
bam-5830	491	2	upand	upand	PROPN
bam-5830	491	3	downhill	downhill	ADV
bam-5830	491	4	treadmill	treadmill	NOUN
bam-5830	491	5	running	run	VERB
bam-5830	491	6	,	,	PUNCT
bam-5830	491	7	mko	mko	PROPN
bam-5830	491	8	and	and	CCONJ
bam-5830	491	9	wt	wt	PROPN
bam-5830	491	10	mice	mouse	NOUN
bam-5830	491	11	performed	perform	VERB
bam-5830	491	12	similarly	similarly	ADV
bam-5830	491	13	.	.	PUNCT
bam-5830	492	1	however	however	ADV
bam-5830	492	2	,	,	PUNCT
bam-5830	492	3	while	while	SCONJ
bam-5830	492	4	the	the	DET
bam-5830	492	5	performance	performance	NOUN
bam-5830	492	6	of	of	ADP
bam-5830	492	7	wt	wt	DET
bam-5830	492	8	mice	mouse	NOUN
bam-5830	492	9	was	be	AUX
bam-5830	492	10	unaffected	unaffected	ADJ
bam-5830	492	11	following	follow	VERB
bam-5830	492	12	four	four	NUM
bam-5830	492	13	consecutive	consecutive	ADJ
bam-5830	492	14	days	day	NOUN
bam-5830	492	15	of	of	ADP
bam-5830	492	16	downhill	downhill	ADV
bam-5830	492	17	running	run	VERB
bam-5830	492	18	,	,	PUNCT
bam-5830	492	19	the	the	DET
bam-5830	492	20	performance	performance	NOUN
bam-5830	492	21	of	of	ADP
bam-5830	492	22	mko	mko	PROPN
bam-5830	492	23	mice	mouse	NOUN
bam-5830	492	24	decreased	decrease	VERB
bam-5830	492	25	progressively	progressively	ADV
bam-5830	492	26	and	and	CCONJ
bam-5830	492	27	signs	sign	NOUN
bam-5830	492	28	of	of	ADP
bam-5830	492	29	muscle	muscle	NOUN
bam-5830	492	30	regeneration	regeneration	NOUN
bam-5830	492	31	following	follow	VERB
bam-5830	492	32	muscle	muscle	NOUN
bam-5830	492	33	damage	damage	NOUN
bam-5830	492	34	were	be	AUX
bam-5830	492	35	observed	observe	VERB
bam-5830	492	36	.	.	PUNCT
bam-5830	493	1	consistent	consistent	ADJ
bam-5830	493	2	with	with	ADP
bam-5830	493	3	a	a	DET
bam-5830	493	4	higher	high	ADJ
bam-5830	493	5	susceptibility	susceptibility	NOUN
bam-5830	493	6	to	to	PART
bam-5830	493	7	muscle	muscle	NOUN
bam-5830	493	8	damage	damage	NOUN
bam-5830	493	9	,	,	PUNCT
bam-5830	493	10	progressive	progressive	ADJ
bam-5830	493	11	z	z	NOUN
bam-5830	493	12	-	-	PUNCT
bam-5830	493	13	line	line	NOUN
bam-5830	493	14	widening	widening	NOUN
bam-5830	493	15	was	be	AUX
bam-5830	493	16	observed	observe	VERB
bam-5830	493	17	in	in	ADP
bam-5830	493	18	mko	mko	PROPN
bam-5830	493	19	skeletal	skeletal	ADJ
bam-5830	493	20	muscle	muscle	NOUN
bam-5830	493	21	from	from	ADP
bam-5830	493	22	about	about	ADV
bam-5830	493	23	8	8	NUM
bam-5830	493	24	months	month	NOUN
bam-5830	493	25	of	of	ADP
bam-5830	493	26	age	age	NOUN
bam-5830	493	27	.	.	PUNCT
bam-5830	494	1	rnaseq	rnaseq	NOUN
bam-5830	494	2	revealed	reveal	VERB
bam-5830	494	3	downregulation	downregulation	NOUN
bam-5830	494	4	of	of	ADP
bam-5830	494	5	actin	actin	NOUN
bam-5830	494	6	isoforms	isoform	NOUN
bam-5830	494	7	and	and	CCONJ
bam-5830	494	8	other	other	ADJ
bam-5830	494	9	srf	srf	ADJ
bam-5830	494	10	-	-	PUNCT
bam-5830	494	11	target	target	NOUN
bam-5830	494	12	genes	gene	NOUN
bam-5830	494	13	in	in	ADP
bam-5830	494	14	mko	mko	PROPN
bam-5830	494	15	muscle	muscle	NOUN
bam-5830	494	16	both	both	CCONJ
bam-5830	494	17	at	at	ADP
bam-5830	494	18	2	2	NUM
bam-5830	494	19	and	and	CCONJ
bam-5830	494	20	4	4	NUM
bam-5830	494	21	weeks	week	NOUN
bam-5830	494	22	of	of	ADP
bam-5830	494	23	age	age	NOUN
bam-5830	494	24	,	,	PUNCT
bam-5830	494	25	suggesting	suggest	VERB
bam-5830	494	26	altered	alter	VERB
bam-5830	494	27	srf	srf	PROPN
bam-5830	494	28	signaling	signal	VERB
bam-5830	494	29	as	as	ADP
bam-5830	494	30	a	a	DET
bam-5830	494	31	possible	possible	ADJ
bam-5830	494	32	explanation	explanation	NOUN
bam-5830	494	33	for	for	ADP
bam-5830	494	34	the	the	DET
bam-5830	494	35	reduced	reduce	VERB
bam-5830	494	36	csa	csa	PROPN
bam-5830	494	37	in	in	ADP
bam-5830	494	38	mko	mko	PROPN
bam-5830	494	39	mice	mouse	NOUN
bam-5830	494	40	.	.	PUNCT
bam-5830	495	1	*	*	PUNCT
bam-5830	495	2	*	*	PUNCT
bam-5830	495	3	*	*	PUNCT
bam-5830	495	4	*	*	PUNCT
bam-5830	495	5	*	*	PUNCT
bam-5830	495	6	micro	micro	NOUN
bam-5830	496	1	-	-	NOUN
bam-5830	497	1	rna206	rna206	NOUN
bam-5830	497	2	and	and	CCONJ
bam-5830	497	3	exosomes	exosome	NOUN
bam-5830	497	4	:	:	PUNCT
bam-5830	497	5	a	a	DET
bam-5830	497	6	retrograde	retrograde	NOUN
bam-5830	497	7	signaling	signal	VERB
bam-5830	497	8	that	that	PRON
bam-5830	497	9	controls	control	VERB
bam-5830	497	10	neuromuscular	neuromuscular	ADJ
bam-5830	497	11	junction	junction	NOUN
bam-5830	497	12	and	and	CCONJ
bam-5830	497	13	tissue	tissue	NOUN
bam-5830	497	14	homeostasis	homeostasis	NOUN
bam-5830	497	15	f.	f.	NOUN
bam-5830	497	16	lo	lo	PROPN
bam-5830	497	17	verso	verso	VERB
bam-5830	497	18	1	1	NUM
bam-5830	497	19	,	,	PUNCT
bam-5830	497	20	r.	r.	PROPN
bam-5830	497	21	soares	soares	PROPN
bam-5830	497	22	1	1	NUM
bam-5830	497	23	,	,	PUNCT
bam-5830	497	24	m.	m.	NOUN
bam-5830	497	25	albiero1	albiero1	PROPN
bam-5830	497	26	,	,	PUNCT
bam-5830	497	27	m.	m.	NOUN
bam-5830	497	28	guescini	guescini	NOUN
bam-5830	497	29	2	2	NUM
bam-5830	497	30	,	,	PUNCT
bam-5830	497	31	m.	m.	NOUN
bam-5830	497	32	sandri	sandri	PROPN
bam-5830	497	33	1,3	1,3	PROPN
bam-5830	497	34	1.venetian	1.venetian	PROPN
bam-5830	497	35	institute	institute	NOUN
bam-5830	497	36	of	of	ADP
bam-5830	497	37	molecular	molecular	ADJ
bam-5830	497	38	medicine	medicine	NOUN
bam-5830	497	39	,	,	PUNCT
bam-5830	497	40	university	university	PROPN
bam-5830	497	41	of	of	ADP
bam-5830	497	42	padua	padua	PROPN
bam-5830	497	43	,	,	PUNCT
bam-5830	497	44	italy	italy	PROPN
bam-5830	497	45	;	;	PUNCT
bam-5830	497	46	2	2	X
bam-5830	497	47	.	.	X
bam-5830	497	48	university	university	NOUN
bam-5830	497	49	of	of	ADP
bam-5830	497	50	urbino	urbino	PROPN
bam-5830	497	51	“	"	PUNCT
bam-5830	497	52	carlo	carlo	PROPN
bam-5830	497	53	bo	bo	PROPN
bam-5830	497	54	”	"	PUNCT
bam-5830	497	55	,	,	PUNCT
bam-5830	497	56	italy	italy	PROPN
bam-5830	497	57	,	,	PUNCT
bam-5830	497	58	3	3	X
bam-5830	497	59	.	.	PUNCT
bam-5830	497	60	telethon	telethon	PROPN
bam-5830	497	61	institute	institute	PROPN
bam-5830	497	62	of	of	ADP
bam-5830	497	63	genetics	genetic	NOUN
bam-5830	497	64	and	and	CCONJ
bam-5830	497	65	medicine	medicine	NOUN
bam-5830	497	66	,	,	PUNCT
bam-5830	497	67	naples	naples	PROPN
bam-5830	497	68	,	,	PUNCT
bam-5830	497	69	italy	italy	PROPN
bam-5830	497	70	e	e	PROPN
bam-5830	497	71	-	-	NOUN
bam-5830	497	72	mail	mail	NOUN
bam-5830	497	73	:	:	PUNCT
bam-5830	498	1	marco.sandri@unipd.it	marco.sandri@unipd.it	NOUN
bam-5830	498	2	impairment	impairment	NOUN
bam-5830	498	3	of	of	ADP
bam-5830	498	4	autophagy	autophagy	NOUN
bam-5830	498	5	in	in	ADP
bam-5830	498	6	muscle	muscle	NOUN
bam-5830	498	7	leads	lead	VERB
bam-5830	498	8	to	to	ADP
bam-5830	498	9	precocious	precocious	ADJ
bam-5830	498	10	ageing1	ageing1	NOUN
bam-5830	498	11	.	.	PUNCT
bam-5830	499	1	in	in	ADP
bam-5830	499	2	particular	particular	ADJ
bam-5830	499	3	,	,	PUNCT
bam-5830	499	4	autophagy	autophagy	ADJ
bam-5830	499	5	deficient	deficient	ADJ
bam-5830	499	6	mice	mouse	NOUN
bam-5830	499	7	are	be	AUX
bam-5830	499	8	characterized	characterize	VERB
bam-5830	499	9	by	by	ADP
bam-5830	499	10	weakness	weakness	NOUN
bam-5830	499	11	are	be	AUX
bam-5830	499	12	atrophy	atrophy	NOUN
bam-5830	499	13	that	that	PRON
bam-5830	499	14	are	be	AUX
bam-5830	499	15	associated	associate	VERB
bam-5830	499	16	with	with	ADP
bam-5830	499	17	alteration	alteration	NOUN
bam-5830	499	18	in	in	ADP
bam-5830	499	19	neuro	neuro	NOUN
bam-5830	499	20	muscular	muscular	ADJ
bam-5830	499	21	junction	junction	NOUN
bam-5830	499	22	(	(	PUNCT
bam-5830	499	23	nmj	nmj	NOUN
bam-5830	499	24	)	)	PUNCT
bam-5830	499	25	and	and	CCONJ
bam-5830	499	26	loss	loss	NOUN
bam-5830	499	27	of	of	ADP
bam-5830	499	28	innervation	innervation	NOUN
bam-5830	499	29	.	.	PUNCT
bam-5830	500	1	in	in	ADP
bam-5830	500	2	order	order	NOUN
bam-5830	500	3	to	to	PART
bam-5830	500	4	investigate	investigate	VERB
bam-5830	500	5	the	the	DET
bam-5830	500	6	cross	cross	NOUN
bam-5830	500	7	-	-	NOUN
bam-5830	500	8	talk	talk	NOUN
bam-5830	500	9	between	between	ADP
bam-5830	500	10	muscle	muscle	NOUN
bam-5830	500	11	and	and	CCONJ
bam-5830	500	12	nerve	nerve	NOUN
bam-5830	500	13	,	,	PUNCT
bam-5830	500	14	we	we	PRON
bam-5830	500	15	found	find	VERB
bam-5830	500	16	that	that	SCONJ
bam-5830	500	17	the	the	DET
bam-5830	500	18	expression	expression	NOUN
bam-5830	500	19	of	of	ADP
bam-5830	500	20	fgfbp1	fgfbp1	PROPN
bam-5830	500	21	,	,	PUNCT
bam-5830	500	22	a	a	DET
bam-5830	500	23	neurotrophic	neurotrophic	ADJ
bam-5830	500	24	factor	factor	NOUN
bam-5830	500	25	that	that	PRON
bam-5830	500	26	is	be	AUX
bam-5830	500	27	critical	critical	ADJ
bam-5830	500	28	to	to	PART
bam-5830	500	29	preserve	preserve	VERB
bam-5830	500	30	muscle	muscle	NOUN
bam-5830	500	31	-	-	PUNCT
bam-5830	500	32	nerve	nerve	NOUN
bam-5830	500	33	interaction	interaction	NOUN
bam-5830	500	34	,	,	PUNCT
bam-5830	500	35	is	be	AUX
bam-5830	500	36	suppressed	suppress	VERB
bam-5830	500	37	in	in	ADP
bam-5830	500	38	muscle	muscle	NOUN
bam-5830	500	39	of	of	ADP
bam-5830	500	40	autophagy	autophagy	ADJ
bam-5830	500	41	deficient	deficient	ADJ
bam-5830	500	42	mice	mouse	NOUN
bam-5830	500	43	.	.	PUNCT
bam-5830	501	1	fgfbp1	fgfbp1	PROPN
bam-5830	501	2	has	have	AUX
bam-5830	501	3	been	be	AUX
bam-5830	501	4	found	find	VERB
bam-5830	501	5	to	to	PART
bam-5830	501	6	be	be	AUX
bam-5830	501	7	regulated	regulate	VERB
bam-5830	501	8	by	by	ADP
bam-5830	501	9	mirna206	mirna206	PROPN
bam-5830	501	10	,	,	PUNCT
bam-5830	501	11	the	the	DET
bam-5830	501	12	muscle	muscle	NOUN
bam-5830	501	13	-	-	PUNCT
bam-5830	501	14	specific	specific	ADJ
bam-5830	501	15	mirna2	mirna2	NOUN
bam-5830	501	16	.	.	PUNCT
bam-5830	502	1	when	when	SCONJ
bam-5830	502	2	we	we	PRON
bam-5830	502	3	checked	check	VERB
bam-5830	502	4	abstracts	abstract	NOUN
bam-5830	502	5	of	of	ADP
bam-5830	502	6	the	the	DET
bam-5830	502	7	xii	xii	PROPN
bam-5830	502	8	iim	iim	NOUN
bam-5830	502	9	myology	myology	NOUN
bam-5830	502	10	meeting	meeting	NOUN
bam-5830	502	11	october	october	PROPN
bam-5830	502	12	1–4	1–4	PROPN
bam-5830	502	13	,	,	PUNCT
bam-5830	502	14	2015	2015	NUM
bam-5830	502	15	eur	eur	PROPN
bam-5830	502	16	j	j	PROPN
bam-5830	502	17	transl	transl	PROPN
bam-5830	502	18	myol	myol	PROPN
bam-5830	502	19	basic	basic	ADJ
bam-5830	502	20	appl	appl	NOUN
bam-5830	502	21	myol	myol	NOUN
bam-5830	502	22	2016	2016	NUM
bam-5830	502	23	;	;	PUNCT
bam-5830	502	24	26	26	NUM
bam-5830	502	25	(	(	PUNCT
bam-5830	502	26	1):2	1):2	NUM
bam-5830	502	27	-	-	SYM
bam-5830	502	28	24	24	NUM
bam-5830	502	29	this	this	DET
bam-5830	502	30	article	article	NOUN
bam-5830	502	31	is	be	AUX
bam-5830	502	32	distributed	distribute	VERB
bam-5830	502	33	under	under	ADP
bam-5830	502	34	the	the	DET
bam-5830	502	35	terms	term	NOUN
bam-5830	502	36	of	of	ADP
bam-5830	502	37	the	the	DET
bam-5830	502	38	creative	creative	ADJ
bam-5830	502	39	commons	common	NOUN
bam-5830	502	40	attribution	attribution	NOUN
bam-5830	502	41	noncommercial	noncommercial	ADJ
bam-5830	502	42	license	license	NOUN
bam-5830	502	43	(	(	PUNCT
bam-5830	502	44	cc	cc	NOUN
bam-5830	502	45	by	by	ADP
bam-5830	502	46	-	-	PUNCT
bam-5830	502	47	nc	nc	PROPN
bam-5830	502	48	4.0	4.0	NUM
bam-5830	502	49	)	)	PUNCT
bam-5830	502	50	which	which	PRON
bam-5830	502	51	permits	permit	VERB
bam-5830	502	52	any	any	DET
bam-5830	502	53	noncommercial	noncommercial	ADJ
bam-5830	502	54	use	use	NOUN
bam-5830	502	55	,	,	PUNCT
bam-5830	502	56	distribution	distribution	NOUN
bam-5830	502	57	,	,	PUNCT
bam-5830	502	58	and	and	CCONJ
bam-5830	502	59	reproduction	reproduction	NOUN
bam-5830	502	60	in	in	ADP
bam-5830	502	61	any	any	DET
bam-5830	502	62	medium	medium	NOUN
bam-5830	502	63	,	,	PUNCT
bam-5830	502	64	provided	provide	VERB
bam-5830	502	65	the	the	DET
bam-5830	502	66	original	original	ADJ
bam-5830	502	67	author(s	author(s	NOUN
bam-5830	502	68	)	)	PUNCT
bam-5830	502	69	and	and	CCONJ
bam-5830	502	70	source	source	NOUN
bam-5830	502	71	are	be	AUX
bam-5830	502	72	credited	credit	VERB
bam-5830	502	73	.	.	PUNCT
bam-5830	503	1	16	16	NUM
bam-5830	504	1	the	the	DET
bam-5830	504	2	level	level	NOUN
bam-5830	504	3	of	of	ADP
bam-5830	504	4	mirna206	mirna206	PROPN
bam-5830	504	5	expression	expression	NOUN
bam-5830	504	6	,	,	PUNCT
bam-5830	504	7	we	we	PRON
bam-5830	504	8	found	find	VERB
bam-5830	504	9	higher	high	ADJ
bam-5830	504	10	level	level	NOUN
bam-5830	504	11	of	of	ADP
bam-5830	504	12	mirna206	mirna206	PROPN
bam-5830	504	13	in	in	ADP
bam-5830	504	14	serum	serum	NOUN
bam-5830	504	15	of	of	ADP
bam-5830	504	16	muscle	muscle	NOUN
bam-5830	504	17	specific	specific	ADJ
bam-5830	504	18	autophagy	autophagy	ADJ
bam-5830	504	19	deficient	deficient	ADJ
bam-5830	504	20	mice	mouse	NOUN
bam-5830	504	21	than	than	ADP
bam-5830	504	22	in	in	ADP
bam-5830	504	23	controls	control	NOUN
bam-5830	504	24	.	.	PUNCT
bam-5830	505	1	importantly	importantly	ADV
bam-5830	505	2	,	,	PUNCT
bam-5830	505	3	mirna206	mirna206	PROPN
bam-5830	505	4	was	be	AUX
bam-5830	505	5	detected	detect	VERB
bam-5830	505	6	in	in	ADP
bam-5830	505	7	the	the	DET
bam-5830	505	8	heart	heart	NOUN
bam-5830	505	9	of	of	ADP
bam-5830	505	10	those	those	DET
bam-5830	505	11	mice	mouse	NOUN
bam-5830	505	12	.	.	PUNCT
bam-5830	506	1	to	to	PART
bam-5830	506	2	understand	understand	VERB
bam-5830	506	3	whether	whether	SCONJ
bam-5830	506	4	autophagy	autophagy	ADJ
bam-5830	506	5	deficient	deficient	ADJ
bam-5830	506	6	muscles	muscle	NOUN
bam-5830	506	7	released	release	VERB
bam-5830	506	8	vesicles	vesicle	NOUN
bam-5830	506	9	containing	contain	VERB
bam-5830	506	10	micrornas	microrna	NOUN
bam-5830	506	11	,	,	PUNCT
bam-5830	506	12	we	we	PRON
bam-5830	506	13	analysed	analyse	VERB
bam-5830	506	14	exosomes	exosome	NOUN
bam-5830	506	15	quantitative	quantitative	ADJ
bam-5830	506	16	rt	rt	ADJ
bam-5830	506	17	-	-	PUNCT
bam-5830	506	18	pcr	pcr	ADJ
bam-5830	506	19	analyses	analysis	NOUN
bam-5830	506	20	confirmed	confirm	VERB
bam-5830	506	21	an	an	DET
bam-5830	506	22	increased	increase	VERB
bam-5830	506	23	expression	expression	NOUN
bam-5830	506	24	of	of	ADP
bam-5830	506	25	mirna206	mirna206	PROPN
bam-5830	506	26	in	in	ADP
bam-5830	506	27	purified	purified	ADJ
bam-5830	506	28	exosomes	exosome	NOUN
bam-5830	506	29	from	from	ADP
bam-5830	506	30	both	both	CCONJ
bam-5830	506	31	denervated	denervated	ADJ
bam-5830	506	32	and	and	CCONJ
bam-5830	506	33	autophagy	autophagy	ADJ
bam-5830	506	34	deficient	deficient	ADJ
bam-5830	506	35	fibers	fiber	NOUN
bam-5830	506	36	.	.	PUNCT
bam-5830	507	1	moreover	moreover	ADV
bam-5830	507	2	expression	expression	NOUN
bam-5830	507	3	of	of	ADP
bam-5830	507	4	bdnf	bdnf	PROPN
bam-5830	507	5	in	in	ADP
bam-5830	507	6	neurons	neuron	NOUN
bam-5830	507	7	treated	treat	VERB
bam-5830	507	8	with	with	ADP
bam-5830	507	9	purified	purified	ADJ
bam-5830	507	10	exosomes	exosome	NOUN
bam-5830	507	11	containing	contain	VERB
bam-5830	507	12	mirna206	mirna206	PROPN
bam-5830	507	13	was	be	AUX
bam-5830	507	14	downregulated	downregulate	VERB
bam-5830	507	15	.	.	PUNCT
bam-5830	508	1	this	this	DET
bam-5830	508	2	finding	finding	NOUN
bam-5830	508	3	suggests	suggest	VERB
bam-5830	508	4	a	a	DET
bam-5830	508	5	potential	potential	ADJ
bam-5830	508	6	role	role	NOUN
bam-5830	508	7	of	of	ADP
bam-5830	508	8	exosomes	exosome	NOUN
bam-5830	508	9	and	and	CCONJ
bam-5830	508	10	mirna206	mirna206	PROPN
bam-5830	508	11	in	in	ADP
bam-5830	508	12	modulating	modulate	VERB
bam-5830	508	13	synaptic	synaptic	ADJ
bam-5830	508	14	plasticity	plasticity	NOUN
bam-5830	508	15	.	.	PUNCT
bam-5830	509	1	in	in	ADP
bam-5830	509	2	order	order	NOUN
bam-5830	509	3	to	to	PART
bam-5830	509	4	mimic	mimic	VERB
bam-5830	509	5	autophagy	autophagy	ADJ
bam-5830	509	6	deficient	deficient	ADJ
bam-5830	509	7	mice	mouse	NOUN
bam-5830	509	8	condition	condition	NOUN
bam-5830	509	9	,	,	PUNCT
bam-5830	509	10	we	we	PRON
bam-5830	509	11	systemically	systemically	ADV
bam-5830	509	12	injected	inject	VERB
bam-5830	509	13	exosomes	exosome	NOUN
bam-5830	509	14	transfected	transfecte	VERB
bam-5830	509	15	with	with	ADP
bam-5830	509	16	mirna206	mirna206	PROPN
bam-5830	509	17	in	in	ADP
bam-5830	509	18	wild	wild	ADJ
bam-5830	509	19	-	-	PUNCT
bam-5830	509	20	type	type	NOUN
bam-5830	509	21	animals	animal	NOUN
bam-5830	509	22	.	.	PUNCT
bam-5830	510	1	mirna206	mirna206	PROPN
bam-5830	510	2	was	be	AUX
bam-5830	510	3	found	find	VERB
bam-5830	510	4	in	in	ADP
bam-5830	510	5	several	several	ADJ
bam-5830	510	6	tissues	tissue	NOUN
bam-5830	510	7	,	,	PUNCT
bam-5830	510	8	in	in	ADP
bam-5830	510	9	particular	particular	ADJ
bam-5830	510	10	liver	liver	NOUN
bam-5830	510	11	and	and	CCONJ
bam-5830	510	12	heart	heart	NOUN
bam-5830	510	13	.	.	PUNCT
bam-5830	511	1	moreover	moreover	ADV
bam-5830	511	2	the	the	DET
bam-5830	511	3	treatment	treatment	NOUN
bam-5830	511	4	was	be	AUX
bam-5830	511	5	sufficient	sufficient	ADJ
bam-5830	511	6	to	to	PART
bam-5830	511	7	induce	induce	VERB
bam-5830	511	8	skeletal	skeletal	ADJ
bam-5830	511	9	muscle	muscle	NOUN
bam-5830	511	10	atrophy	atrophy	NOUN
bam-5830	511	11	and	and	CCONJ
bam-5830	511	12	changes	change	NOUN
bam-5830	511	13	in	in	ADP
bam-5830	511	14	the	the	DET
bam-5830	511	15	expression	expression	NOUN
bam-5830	511	16	of	of	ADP
bam-5830	511	17	several	several	ADJ
bam-5830	511	18	neurotrophic	neurotrophic	ADJ
bam-5830	511	19	factors	factor	NOUN
bam-5830	511	20	.	.	PUNCT
bam-5830	512	1	these	these	DET
bam-5830	512	2	data	datum	NOUN
bam-5830	512	3	support	support	VERB
bam-5830	512	4	the	the	DET
bam-5830	512	5	role	role	NOUN
bam-5830	512	6	of	of	ADP
bam-5830	512	7	exosome	exosome	NOUN
bam-5830	512	8	as	as	ADP
bam-5830	512	9	a	a	DET
bam-5830	512	10	signaling	signal	VERB
bam-5830	512	11	mechanism	mechanism	NOUN
bam-5830	512	12	that	that	PRON
bam-5830	512	13	connects	connect	VERB
bam-5830	512	14	muscle	muscle	NOUN
bam-5830	512	15	with	with	ADP
bam-5830	512	16	different	different	ADJ
bam-5830	512	17	tissues	tissue	NOUN
bam-5830	512	18	including	include	VERB
bam-5830	512	19	motorneuron	motorneuron	NOUN
bam-5830	512	20	,	,	PUNCT
bam-5830	512	21	heart	heart	NOUN
bam-5830	512	22	and	and	CCONJ
bam-5830	512	23	liver	liver	NOUN
bam-5830	512	24	.	.	PUNCT
bam-5830	513	1	carnio	carnio	INTJ
bam-5830	513	2	et	et	PROPN
bam-5830	513	3	al	al	PROPN
bam-5830	513	4	.	.	PROPN
bam-5830	513	5	,	,	PUNCT
bam-5830	513	6	cell	cell	NOUN
bam-5830	513	7	rep	rep	PROPN
bam-5830	513	8	,	,	PUNCT
bam-5830	513	9	2014	2014	NUM
bam-5830	513	10	.	.	PUNCT
bam-5830	514	1	williams	williams	PROPN
bam-5830	514	2	et	et	PROPN
bam-5830	514	3	al	al	PROPN
bam-5830	514	4	.	.	PROPN
bam-5830	514	5	,	,	PUNCT
bam-5830	514	6	science	science	NOUN
bam-5830	514	7	,	,	PUNCT
bam-5830	514	8	2009	2009	NUM
bam-5830	514	9	.	.	PUNCT
bam-5830	515	1	*	*	PUNCT
bam-5830	515	2	*	*	PUNCT
bam-5830	515	3	*	*	PUNCT
bam-5830	515	4	*	*	PUNCT
bam-5830	515	5	*	*	PUNCT
bam-5830	515	6	microrna	microrna	PROPN
bam-5830	515	7	signature	signature	NOUN
bam-5830	515	8	in	in	ADP
bam-5830	515	9	mdx	mdx	PROPN
bam-5830	515	10	dystrophic	dystrophic	ADJ
bam-5830	515	11	mice	mouse	NOUN
bam-5830	515	12	overexpressing	overexpresse	VERB
bam-5830	515	13	migf-1	migf-1	NUM
bam-5830	515	14	l.	l.	PROPN
bam-5830	515	15	pelosi	pelosi	PROPN
bam-5830	515	16	1	1	NUM
bam-5830	515	17	,	,	PUNCT
bam-5830	515	18	a.	a.	PROPN
bam-5830	515	19	coggi	coggi	PROPN
bam-5830	515	20	1	1	NUM
bam-5830	515	21	,	,	PUNCT
bam-5830	515	22	l.	l.	PROPN
bam-5830	515	23	forcina	forcina	PROPN
bam-5830	515	24	1	1	NUM
bam-5830	515	25	,	,	PUNCT
bam-5830	515	26	a.	a.	NOUN
bam-5830	515	27	musarò	musarò	NOUN
bam-5830	515	28	1,2	1,2	NUM
bam-5830	515	29	1	1	NUM
bam-5830	515	30	.	.	PUNCT
bam-5830	515	31	institute	institute	PROPN
bam-5830	515	32	pasteur	pasteur	PROPN
bam-5830	515	33	cenci	cenci	PROPN
bam-5830	515	34	-	-	PUNCT
bam-5830	515	35	bolognetti	bolognetti	PROPN
bam-5830	515	36	dahfmo	dahfmo	NOUN
bam-5830	515	37	-	-	PUNCT
bam-5830	515	38	histology	histology	NOUN
bam-5830	515	39	and	and	CCONJ
bam-5830	515	40	medical	medical	ADJ
bam-5830	515	41	embryology	embryology	NOUN
bam-5830	515	42	unit	unit	NOUN
bam-5830	515	43	,	,	PUNCT
bam-5830	515	44	iim	iim	PROPN
bam-5830	515	45	,	,	PUNCT
bam-5830	515	46	sapienza	sapienza	PROPN
bam-5830	515	47	university	university	PROPN
bam-5830	515	48	of	of	ADP
bam-5830	515	49	rome	rome	PROPN
bam-5830	515	50	,	,	PUNCT
bam-5830	515	51	italy	italy	PROPN
bam-5830	515	52	;	;	PUNCT
bam-5830	515	53	2	2	X
bam-5830	515	54	.	.	X
bam-5830	515	55	center	center	NOUN
bam-5830	515	56	for	for	ADP
bam-5830	515	57	life	life	NOUN
bam-5830	515	58	nano	nano	NOUN
bam-5830	515	59	science@sapienza	science@sapienza	PUNCT
bam-5830	515	60	istituto	istituto	X
bam-5830	515	61	italiano	italiano	PROPN
bam-5830	515	62	di	di	X
bam-5830	515	63	tecnologia	tecnologia	PROPN
bam-5830	515	64	,	,	PUNCT
bam-5830	515	65	rome	rome	PROPN
bam-5830	515	66	,	,	PUNCT
bam-5830	515	67	italy	italy	PROPN
bam-5830	515	68	e	e	PROPN
bam-5830	515	69	-	-	NOUN
bam-5830	515	70	mail	mail	NOUN
bam-5830	515	71	:	:	PUNCT
bam-5830	515	72	laura.forcina@uniroma1.it	laura.forcina@uniroma1.it	NOUN
bam-5830	515	73	duchenne	duchenne	VERB
bam-5830	515	74	muscular	muscular	ADJ
bam-5830	515	75	dystrophy	dystrophy	NOUN
bam-5830	515	76	(	(	PUNCT
bam-5830	515	77	dmd	dmd	NOUN
bam-5830	515	78	)	)	PUNCT
bam-5830	515	79	is	be	AUX
bam-5830	515	80	a	a	DET
bam-5830	515	81	genetic	genetic	ADJ
bam-5830	515	82	disease	disease	NOUN
bam-5830	515	83	in	in	ADP
bam-5830	515	84	which	which	DET
bam-5830	515	85	loss	loss	NOUN
bam-5830	515	86	of	of	ADP
bam-5830	515	87	functional	functional	ADJ
bam-5830	515	88	dystrophin	dystrophin	ADJ
bam-5830	515	89	protein	protein	NOUN
bam-5830	515	90	results	result	NOUN
bam-5830	515	91	in	in	ADP
bam-5830	515	92	progressive	progressive	ADJ
bam-5830	515	93	skeletal	skeletal	ADJ
bam-5830	515	94	muscle	muscle	NOUN
bam-5830	515	95	degeneration	degeneration	NOUN
bam-5830	515	96	.	.	PUNCT
bam-5830	516	1	although	although	SCONJ
bam-5830	516	2	the	the	DET
bam-5830	516	3	genetic	genetic	ADJ
bam-5830	516	4	defect	defect	NOUN
bam-5830	516	5	is	be	AUX
bam-5830	516	6	widely	widely	ADV
bam-5830	516	7	known	know	VERB
bam-5830	516	8	,	,	PUNCT
bam-5830	516	9	the	the	DET
bam-5830	516	10	mechanisms	mechanism	NOUN
bam-5830	516	11	by	by	ADP
bam-5830	516	12	which	which	PRON
bam-5830	516	13	the	the	DET
bam-5830	516	14	absence	absence	NOUN
bam-5830	516	15	of	of	ADP
bam-5830	516	16	dystrophin	dystrophin	NOUN
bam-5830	516	17	leads	lead	NOUN
bam-5830	516	18	to	to	ADP
bam-5830	516	19	the	the	DET
bam-5830	516	20	complex	complex	ADJ
bam-5830	516	21	pathophisiology	pathophisiology	NOUN
bam-5830	516	22	of	of	ADP
bam-5830	516	23	the	the	DET
bam-5830	516	24	disease	disease	NOUN
bam-5830	516	25	is	be	AUX
bam-5830	516	26	not	not	PART
bam-5830	516	27	completely	completely	ADV
bam-5830	516	28	understood	understand	VERB
bam-5830	516	29	.	.	PUNCT
bam-5830	517	1	mirnas	mirna	NOUN
bam-5830	517	2	are	be	AUX
bam-5830	517	3	small	small	ADJ
bam-5830	517	4	non	non	ADJ
bam-5830	517	5	coding	code	VERB
bam-5830	517	6	rna	rna	NOUN
bam-5830	517	7	that	that	PRON
bam-5830	517	8	are	be	AUX
bam-5830	517	9	important	important	ADJ
bam-5830	517	10	regulatory	regulatory	ADJ
bam-5830	517	11	elements	element	NOUN
bam-5830	517	12	for	for	ADP
bam-5830	517	13	muscle	muscle	NOUN
bam-5830	517	14	development	development	NOUN
bam-5830	517	15	and	and	CCONJ
bam-5830	517	16	function	function	NOUN
bam-5830	517	17	[	[	X
bam-5830	517	18	1	1	NUM
bam-5830	517	19	]	]	PUNCT
bam-5830	517	20	.	.	PUNCT
bam-5830	518	1	altered	altered	ADJ
bam-5830	518	2	levels	level	NOUN
bam-5830	518	3	of	of	ADP
bam-5830	518	4	specific	specific	ADJ
bam-5830	518	5	mirnas	mirna	NOUN
bam-5830	518	6	were	be	AUX
bam-5830	518	7	found	find	VERB
bam-5830	518	8	in	in	ADP
bam-5830	518	9	several	several	ADJ
bam-5830	518	10	muscular	muscular	ADJ
bam-5830	518	11	disorders	disorder	NOUN
bam-5830	518	12	,	,	PUNCT
bam-5830	518	13	including	include	VERB
bam-5830	518	14	dmd	dmd	NOUN
bam-5830	518	15	[	[	X
bam-5830	518	16	2	2	NUM
bam-5830	518	17	,	,	PUNCT
bam-5830	518	18	3	3	NUM
bam-5830	518	19	]	]	PUNCT
bam-5830	518	20	.	.	PUNCT
bam-5830	519	1	in	in	ADP
bam-5830	519	2	particular	particular	ADJ
bam-5830	519	3	it	it	PRON
bam-5830	519	4	has	have	AUX
bam-5830	519	5	been	be	AUX
bam-5830	519	6	identified	identify	VERB
bam-5830	519	7	a	a	DET
bam-5830	519	8	specific	specific	ADJ
bam-5830	519	9	dmd	dmd	ADJ
bam-5830	519	10	-	-	PUNCT
bam-5830	519	11	signature	signature	NOUN
bam-5830	519	12	mirnas	mirna	NOUN
bam-5830	519	13	that	that	PRON
bam-5830	519	14	may	may	AUX
bam-5830	519	15	serve	serve	VERB
bam-5830	519	16	as	as	ADP
bam-5830	519	17	a	a	DET
bam-5830	519	18	marker	marker	NOUN
bam-5830	519	19	for	for	ADP
bam-5830	519	20	therapeutic	therapeutic	ADJ
bam-5830	519	21	purposes	purpose	NOUN
bam-5830	519	22	[	[	X
bam-5830	519	23	4	4	NUM
bam-5830	519	24	]	]	PUNCT
bam-5830	519	25	.	.	PUNCT
bam-5830	520	1	moreover	moreover	ADV
bam-5830	520	2	,	,	PUNCT
bam-5830	520	3	in	in	ADP
bam-5830	520	4	a	a	DET
bam-5830	520	5	recent	recent	ADJ
bam-5830	520	6	work	work	NOUN
bam-5830	520	7	it	it	PRON
bam-5830	520	8	has	have	AUX
bam-5830	520	9	been	be	AUX
bam-5830	520	10	defined	define	VERB
bam-5830	520	11	a	a	DET
bam-5830	520	12	specific	specific	ADJ
bam-5830	520	13	group	group	NOUN
bam-5830	520	14	of	of	ADP
bam-5830	520	15	mirnas	mirna	NOUN
bam-5830	520	16	strictly	strictly	ADV
bam-5830	520	17	correlated	correlate	VERB
bam-5830	520	18	to	to	ADP
bam-5830	520	19	dystrophin	dystrophin	ADJ
bam-5830	520	20	levels	level	NOUN
bam-5830	520	21	and	and	CCONJ
bam-5830	520	22	whose	whose	DET
bam-5830	520	23	deregulated	deregulated	ADJ
bam-5830	520	24	expression	expression	NOUN
bam-5830	520	25	could	could	AUX
bam-5830	520	26	explain	explain	VERB
bam-5830	520	27	several	several	ADJ
bam-5830	520	28	pathogenetic	pathogenetic	ADJ
bam-5830	520	29	features	feature	NOUN
bam-5830	520	30	of	of	ADP
bam-5830	520	31	dmd	dmd	NOUN
bam-5830	520	32	[	[	X
bam-5830	520	33	5	5	NUM
bam-5830	520	34	]	]	PUNCT
bam-5830	520	35	.	.	PUNCT
bam-5830	521	1	previously	previously	ADV
bam-5830	521	2	we	we	PRON
bam-5830	521	3	have	have	AUX
bam-5830	521	4	demonstrated	demonstrate	VERB
bam-5830	521	5	that	that	SCONJ
bam-5830	521	6	the	the	DET
bam-5830	521	7	local	local	ADJ
bam-5830	521	8	expression	expression	NOUN
bam-5830	521	9	of	of	ADP
bam-5830	521	10	migf-1	migf-1	NUM
bam-5830	521	11	in	in	ADP
bam-5830	521	12	mdx	mdx	NOUN
bam-5830	521	13	mice	mouse	NOUN
bam-5830	521	14	ameliorates	ameliorate	VERB
bam-5830	521	15	the	the	DET
bam-5830	521	16	dystrophic	dystrophic	ADJ
bam-5830	521	17	phenotype	phenotype	NOUN
bam-5830	521	18	reducing	reduce	VERB
bam-5830	521	19	myonecrosis	myonecrosis	NOUN
bam-5830	521	20	and	and	CCONJ
bam-5830	521	21	upregulating	upregulating	ADJ
bam-5830	521	22	survival	survival	NOUN
bam-5830	521	23	pathways	pathway	NOUN
bam-5830	521	24	such	such	ADJ
bam-5830	521	25	as	as	ADP
bam-5830	521	26	akt	akt	PROPN
bam-5830	521	27	pathway	pathway	NOUN
bam-5830	522	1	[	[	X
bam-5830	522	2	6	6	NUM
bam-5830	522	3	]	]	PUNCT
bam-5830	522	4	.	.	PUNCT
bam-5830	523	1	in	in	ADP
bam-5830	523	2	this	this	DET
bam-5830	523	3	work	work	NOUN
bam-5830	523	4	,	,	PUNCT
bam-5830	523	5	we	we	PRON
bam-5830	523	6	show	show	VERB
bam-5830	523	7	that	that	SCONJ
bam-5830	523	8	a	a	DET
bam-5830	523	9	specific	specific	ADJ
bam-5830	523	10	group	group	NOUN
bam-5830	523	11	of	of	ADP
bam-5830	523	12	mirnas	mirna	NOUN
bam-5830	523	13	,	,	PUNCT
bam-5830	523	14	dystrophinindipendent	dystrophinindipendent	PROPN
bam-5830	523	15	,	,	PUNCT
bam-5830	523	16	are	be	AUX
bam-5830	523	17	modulated	modulate	VERB
bam-5830	523	18	by	by	ADP
bam-5830	523	19	migf-1	migf-1	NUM
bam-5830	523	20	expression	expression	NOUN
bam-5830	523	21	.	.	PUNCT
bam-5830	524	1	in	in	ADP
bam-5830	524	2	particular	particular	ADJ
bam-5830	524	3	,	,	PUNCT
bam-5830	524	4	local	local	ADJ
bam-5830	524	5	expression	expression	NOUN
bam-5830	524	6	of	of	ADP
bam-5830	524	7	migf-1	migf-1	NUM
bam-5830	524	8	promotes	promote	VERB
bam-5830	524	9	the	the	DET
bam-5830	524	10	modulation	modulation	NOUN
bam-5830	524	11	of	of	ADP
bam-5830	524	12	mir-206	mir-206	NOUN
bam-5830	524	13	and	and	CCONJ
bam-5830	524	14	mir-24	mir-24	NOUN
bam-5830	524	15	as	as	ADV
bam-5830	524	16	well	well	ADV
bam-5830	524	17	as	as	ADP
bam-5830	524	18	muscle	muscle	NOUN
bam-5830	524	19	specific	specific	ADJ
bam-5830	524	20	genes	gene	NOUN
bam-5830	524	21	associated	associate	VERB
bam-5830	524	22	with	with	ADP
bam-5830	524	23	maturation	maturation	NOUN
bam-5830	524	24	of	of	ADP
bam-5830	524	25	regenerating	regenerate	VERB
bam-5830	524	26	muscle	muscle	NOUN
bam-5830	524	27	fibers	fiber	NOUN
bam-5830	524	28	and	and	CCONJ
bam-5830	524	29	differentiation	differentiation	NOUN
bam-5830	524	30	.	.	PUNCT
bam-5830	525	1	these	these	DET
bam-5830	525	2	results	result	NOUN
bam-5830	525	3	indicates	indicate	VERB
bam-5830	525	4	that	that	SCONJ
bam-5830	525	5	local	local	ADJ
bam-5830	525	6	overexpression	overexpression	NOUN
bam-5830	525	7	of	of	ADP
bam-5830	525	8	the	the	DET
bam-5830	525	9	anabolic	anabolic	NOUN
bam-5830	525	10	factor	factor	NOUN
bam-5830	525	11	migf-1	migf-1	NUM
bam-5830	525	12	in	in	ADP
bam-5830	525	13	mdx	mdx	NOUN
bam-5830	525	14	mice	mouse	NOUN
bam-5830	525	15	ameliorates	ameliorate	VERB
bam-5830	525	16	the	the	DET
bam-5830	525	17	dystrophic	dystrophic	ADJ
bam-5830	525	18	microenviroment	microenviroment	NOUN
bam-5830	525	19	modulating	modulate	VERB
bam-5830	525	20	the	the	DET
bam-5830	525	21	expression	expression	NOUN
bam-5830	525	22	of	of	ADP
bam-5830	525	23	a	a	DET
bam-5830	525	24	specific	specific	ADJ
bam-5830	525	25	group	group	NOUN
bam-5830	525	26	of	of	ADP
bam-5830	525	27	mirnas	mirna	NOUN
bam-5830	525	28	and	and	CCONJ
bam-5830	525	29	inducing	induce	VERB
bam-5830	525	30	a	a	DET
bam-5830	525	31	partial	partial	ADJ
bam-5830	525	32	rescue	rescue	NOUN
bam-5830	525	33	of	of	ADP
bam-5830	525	34	the	the	DET
bam-5830	525	35	characteristic	characteristic	ADJ
bam-5830	525	36	dmd	dmd	NOUN
bam-5830	525	37	-	-	NOUN
bam-5830	525	38	signature	signature	NOUN
bam-5830	525	39	.	.	PUNCT
bam-5830	526	1	1	1	X
bam-5830	526	2	.	.	X
bam-5830	527	1	eisenberg	eisenberg	PROPN
bam-5830	527	2	i	i	PRON
bam-5830	527	3	,	,	PUNCT
bam-5830	527	4	et	et	PROPN
bam-5830	527	5	al	al	PROPN
bam-5830	527	6	.	.	PUNCT
bam-5830	528	1	j	j	PROPN
bam-5830	528	2	cell	cell	PROPN
bam-5830	528	3	mol	mol	ADP
bam-5830	528	4	med	med	ADJ
bam-5830	528	5	2009;13:2–11	2009;13:2–11	NUM
bam-5830	528	6	.	.	PUNCT
bam-5830	529	1	2	2	NUM
bam-5830	529	2	.	.	X
bam-5830	529	3	eisenberg	eisenberg	PROPN
bam-5830	529	4	i	i	PRON
bam-5830	529	5	,	,	PUNCT
bam-5830	529	6	et	et	PROPN
bam-5830	529	7	al	al	PROPN
bam-5830	529	8	.	.	PUNCT
bam-5830	529	9	procnatlacadsci	procnatlacadsci	PROPN
bam-5830	529	10	usa	usa	PROPN
bam-5830	529	11	2007;104:1701621	2007;104:1701621	NUM
bam-5830	529	12	.	.	PUNCT
bam-5830	530	1	3	3	X
bam-5830	530	2	.	.	X
bam-5830	530	3	greco	greco	PROPN
bam-5830	530	4	s	s	PROPN
bam-5830	530	5	,	,	PUNCT
bam-5830	531	1	et	et	PROPN
bam-5830	531	2	al	al	PROPN
bam-5830	531	3	.	.	PROPN
bam-5830	531	4	faseb	faseb	PROPN
bam-5830	531	5	j	j	PROPN
bam-5830	531	6	2009;23:3335	2009;23:3335	NUM
bam-5830	531	7	-	-	SYM
bam-5830	531	8	46	46	NUM
bam-5830	531	9	.	.	PUNCT
bam-5830	532	1	4	4	NUM
bam-5830	532	2	.	.	X
bam-5830	532	3	lang	lang	PROPN
bam-5830	532	4	jm	jm	PROPN
bam-5830	532	5	,	,	PUNCT
bam-5830	532	6	et	et	PROPN
bam-5830	532	7	al	al	PROPN
bam-5830	532	8	.	.	PROPN
bam-5830	533	1	exp	exp	PROPN
bam-5830	533	2	biol	biol	PROPN
bam-5830	533	3	med	med	PROPN
bam-5830	533	4	(	(	PUNCT
bam-5830	533	5	maywood	maywood	PROPN
bam-5830	533	6	)	)	PUNCT
bam-5830	533	7	2004;229:50311	2004;229:50311	NUM
bam-5830	533	8	.	.	PUNCT
bam-5830	534	1	5	5	NUM
bam-5830	534	2	.	.	X
bam-5830	534	3	cacchiarelli	cacchiarelli	PROPN
bam-5830	534	4	d.	d.	PROPN
bam-5830	534	5	,	,	PUNCT
bam-5830	534	6	et	et	PROPN
bam-5830	534	7	al	al	PROPN
bam-5830	534	8	.	.	PROPN
bam-5830	534	9	cell	cell	PROPN
bam-5830	534	10	metab	metab	PROPN
bam-5830	534	11	2010;12:341	2010;12:341	PROPN
bam-5830	534	12	-	-	SYM
bam-5830	534	13	51	51	NUM
bam-5830	534	14	.	.	NOUN
bam-5830	535	1	6	6	NUM
bam-5830	535	2	.	.	X
bam-5830	536	1	barton	barton	PROPN
bam-5830	536	2	er	er	INTJ
bam-5830	536	3	.	.	PROPN
bam-5830	536	4	,	,	PUNCT
bam-5830	536	5	et	et	PROPN
bam-5830	536	6	al	al	PROPN
bam-5830	536	7	.	.	PROPN
bam-5830	536	8	,	,	PUNCT
bam-5830	536	9	j	j	PROPN
bam-5830	536	10	cell	cell	NOUN
bam-5830	536	11	biol	biol	PROPN
bam-5830	536	12	2002;157:137	2002;157:137	NUM
bam-5830	536	13	-	-	SYM
bam-5830	536	14	48	48	NUM
bam-5830	536	15	.	.	PUNCT
bam-5830	537	1	*	*	PUNCT
bam-5830	537	2	*	*	PUNCT
bam-5830	537	3	*	*	PUNCT
bam-5830	537	4	*	*	PUNCT
bam-5830	537	5	*	*	PUNCT
bam-5830	537	6	circular	circular	ADJ
bam-5830	537	7	rnas	rna	NOUN
bam-5830	537	8	expression	expression	NOUN
bam-5830	537	9	and	and	CCONJ
bam-5830	537	10	function	function	NOUN
bam-5830	537	11	in	in	ADP
bam-5830	537	12	myogenesis	myogenesis	NOUN
bam-5830	537	13	i.	i.	PROPN
bam-5830	537	14	legnini	legnini	PROPN
bam-5830	537	15	1	1	PROPN
bam-5830	537	16	,	,	PUNCT
bam-5830	537	17	g.	g.	PROPN
bam-5830	537	18	di	di	PROPN
bam-5830	537	19	timoteo	timoteo	PROPN
bam-5830	537	20	1	1	NUM
bam-5830	537	21	,	,	PUNCT
bam-5830	537	22	f.	f.	PROPN
bam-5830	537	23	rossi	rossi	PROPN
bam-5830	537	24	1	1	NUM
bam-5830	537	25	,	,	PUNCT
bam-5830	537	26	f.	f.	PROPN
bam-5830	537	27	briganti	briganti	PROPN
bam-5830	537	28	1	1	NUM
bam-5830	537	29	,	,	PUNCT
bam-5830	537	30	o.	o.	NOUN
bam-5830	537	31	sthandier	sthandier	NOUN
bam-5830	537	32	1	1	NUM
bam-5830	537	33	,	,	PUNCT
bam-5830	537	34	m.	m.	NOUN
bam-5830	537	35	morlando	morlando	NOUN
bam-5830	537	36	1	1	NUM
bam-5830	537	37	,	,	PUNCT
bam-5830	537	38	a.	a.	NOUN
bam-5830	537	39	fatica	fatica	PROPN
bam-5830	537	40	1	1	NUM
bam-5830	537	41	,	,	PUNCT
bam-5830	537	42	a.	a.	NOUN
bam-5830	537	43	andronache	andronache	NOUN
bam-5830	537	44	2	2	NUM
bam-5830	537	45	,	,	PUNCT
bam-5830	537	46	m.	m.	PROPN
bam-5830	537	47	wade	wade	PROPN
bam-5830	537	48	2	2	NUM
bam-5830	537	49	,	,	PUNCT
bam-5830	537	50	n.	n.	NOUN
bam-5830	537	51	rajewsky	rajewsky	PROPN
bam-5830	537	52	3	3	NUM
bam-5830	537	53	,	,	PUNCT
bam-5830	537	54	i.	i.	PROPN
bam-5830	537	55	bozzoni	bozzoni	NOUN
bam-5830	537	56	1,4,5	1,4,5	NUM
bam-5830	537	57	1	1	NUM
bam-5830	537	58	.	.	PUNCT
bam-5830	537	59	dip	dip	NOUN
bam-5830	537	60	.	.	PUNCT
bam-5830	538	1	biologia	biologia	PROPN
bam-5830	538	2	e	e	PROPN
bam-5830	538	3	biotecnologie	biotecnologie	PROPN
bam-5830	538	4	,	,	PUNCT
bam-5830	538	5	sapienza	sapienza	PROPN
bam-5830	538	6	university	university	PROPN
bam-5830	538	7	rome	rome	PROPN
bam-5830	538	8	;	;	PUNCT
bam-5830	538	9	2	2	X
bam-5830	538	10	.	.	X
bam-5830	538	11	center	center	NOUN
bam-5830	538	12	for	for	ADP
bam-5830	538	13	genomic	genomic	ADJ
bam-5830	538	14	science	science	NOUN
bam-5830	538	15	of	of	ADP
bam-5830	538	16	iit@semm	iit@semm	NOUN
bam-5830	538	17	,	,	PUNCT
bam-5830	538	18	istituto	istituto	X
bam-5830	538	19	italiano	italiano	NOUN
bam-5830	538	20	di	di	X
bam-5830	538	21	tecnologia	tecnologia	PROPN
bam-5830	538	22	,	,	PUNCT
bam-5830	538	23	milano	milano	PROPN
bam-5830	538	24	italy	italy	PROPN
bam-5830	538	25	;	;	PUNCT
bam-5830	538	26	3	3	X
bam-5830	538	27	.	.	X
bam-5830	538	28	berlin	berlin	PROPN
bam-5830	538	29	institute	institute	PROPN
bam-5830	538	30	for	for	ADP
bam-5830	538	31	medical	medical	ADJ
bam-5830	538	32	systems	system	NOUN
bam-5830	538	33	biology	biology	NOUN
bam-5830	538	34	,	,	PUNCT
bam-5830	538	35	max	max	PROPN
bam-5830	538	36	delbruck	delbruck	PROPN
bam-5830	538	37	center	center	NOUN
bam-5830	538	38	for	for	ADP
bam-5830	538	39	molecular	molecular	ADJ
bam-5830	538	40	medicine	medicine	NOUN
bam-5830	538	41	,	,	PUNCT
bam-5830	538	42	germany	germany	PROPN
bam-5830	538	43	;	;	PUNCT
bam-5830	538	44	4	4	X
bam-5830	538	45	.	.	X
bam-5830	538	46	center	center	NOUN
bam-5830	538	47	for	for	ADP
bam-5830	538	48	life	life	NOUN
bam-5830	538	49	nano	nano	NOUN
bam-5830	538	50	science@sapienza	science@sapienza	NOUN
bam-5830	538	51	,	,	PUNCT
bam-5830	538	52	istituto	istituto	X
bam-5830	538	53	italiano	italiano	NOUN
bam-5830	538	54	di	di	X
bam-5830	538	55	tecnologia	tecnologia	PROPN
bam-5830	538	56	,	,	PUNCT
bam-5830	538	57	roma	roma	PROPN
bam-5830	538	58	,	,	PUNCT
bam-5830	538	59	italy	italy	PROPN
bam-5830	538	60	;	;	PUNCT
bam-5830	538	61	5	5	X
bam-5830	538	62	.	.	X
bam-5830	538	63	istituto	istituto	PROPN
bam-5830	538	64	pasteur	pasteur	PROPN
bam-5830	538	65	–	–	PUNCT
bam-5830	538	66	fondazione	fondazione	PROPN
bam-5830	538	67	cenci	cenci	NOUN
bam-5830	538	68	bolognetti	bolognetti	PROPN
bam-5830	538	69	,	,	PUNCT
bam-5830	538	70	rome	rome	PROPN
bam-5830	538	71	,	,	PUNCT
bam-5830	538	72	italy	italy	PROPN
bam-5830	538	73	e	e	PROPN
bam-5830	538	74	-	-	NOUN
bam-5830	538	75	mail	mail	NOUN
bam-5830	538	76	:	:	PUNCT
bam-5830	538	77	ivano.legnini@uniroma1.it	ivano.legnini@uniroma1.it	NOUN
bam-5830	538	78	circular	circular	ADJ
bam-5830	538	79	rnas	rna	NOUN
bam-5830	538	80	have	have	AUX
bam-5830	538	81	been	be	AUX
bam-5830	538	82	recently	recently	ADV
bam-5830	538	83	re	re	VERB
bam-5830	538	84	-	-	VERB
bam-5830	538	85	discovered	discover	VERB
bam-5830	538	86	as	as	ADP
bam-5830	538	87	a	a	DET
bam-5830	538	88	large	large	ADJ
bam-5830	538	89	class	class	NOUN
bam-5830	538	90	of	of	ADP
bam-5830	538	91	putative	putative	ADJ
bam-5830	538	92	non	non	ADJ
bam-5830	538	93	-	-	ADJ
bam-5830	538	94	coding	coding	ADJ
bam-5830	538	95	rnas	rna	NOUN
bam-5830	538	96	with	with	ADP
bam-5830	538	97	a	a	DET
bam-5830	538	98	peculiar	peculiar	ADJ
bam-5830	538	99	structure	structure	NOUN
bam-5830	538	100	and	and	CCONJ
bam-5830	538	101	poorly	poorly	ADV
bam-5830	538	102	understood	understand	VERB
bam-5830	538	103	functions	function	NOUN
bam-5830	538	104	.	.	PUNCT
bam-5830	539	1	although	although	SCONJ
bam-5830	539	2	their	their	PRON
bam-5830	539	3	biogenesis	biogenesis	NOUN
bam-5830	539	4	,	,	PUNCT
bam-5830	539	5	which	which	PRON
bam-5830	539	6	proceeds	proceed	VERB
bam-5830	539	7	via	via	ADP
bam-5830	539	8	a	a	DET
bam-5830	539	9	back	back	ADJ
bam-5830	539	10	-	-	PUNCT
bam-5830	539	11	splicing	splicing	NOUN
bam-5830	539	12	reaction	reaction	NOUN
bam-5830	539	13	,	,	PUNCT
bam-5830	539	14	has	have	AUX
bam-5830	539	15	been	be	AUX
bam-5830	539	16	studied	study	VERB
bam-5830	539	17	and	and	CCONJ
bam-5830	539	18	dissected	dissect	VERB
bam-5830	539	19	in	in	ADP
bam-5830	539	20	the	the	DET
bam-5830	539	21	last	last	ADJ
bam-5830	539	22	years	year	NOUN
bam-5830	539	23	,	,	PUNCT
bam-5830	539	24	their	their	PRON
bam-5830	539	25	role	role	NOUN
bam-5830	539	26	in	in	ADP
bam-5830	539	27	biologically	biologically	ADV
bam-5830	539	28	relevant	relevant	ADJ
bam-5830	539	29	processes	process	NOUN
bam-5830	539	30	is	be	AUX
bam-5830	539	31	still	still	ADV
bam-5830	539	32	uncharacterized	uncharacterized	ADJ
bam-5830	539	33	.	.	PUNCT
bam-5830	540	1	here	here	ADV
bam-5830	540	2	,	,	PUNCT
bam-5830	540	3	we	we	PRON
bam-5830	540	4	performed	perform	VERB
bam-5830	540	5	expression	expression	NOUN
bam-5830	540	6	profiling	profiling	NOUN
bam-5830	540	7	of	of	ADP
bam-5830	540	8	circrnas	circrna	NOUN
bam-5830	540	9	during	during	ADP
bam-5830	540	10	in	in	ADP
bam-5830	540	11	vitro	vitro	X
bam-5830	540	12	differentiation	differentiation	NOUN
bam-5830	540	13	of	of	ADP
bam-5830	540	14	murine	murine	ADJ
bam-5830	540	15	and	and	CCONJ
bam-5830	540	16	human	human	ADJ
bam-5830	540	17	myoblasts	myoblast	NOUN
bam-5830	540	18	,	,	PUNCT
bam-5830	540	19	we	we	PRON
bam-5830	540	20	selected	select	VERB
bam-5830	540	21	and	and	CCONJ
bam-5830	540	22	validated	validate	VERB
bam-5830	540	23	the	the	DET
bam-5830	540	24	expression	expression	NOUN
bam-5830	540	25	of	of	ADP
bam-5830	540	26	a	a	DET
bam-5830	540	27	subset	subset	NOUN
bam-5830	540	28	of	of	ADP
bam-5830	540	29	highly	highly	ADV
bam-5830	540	30	expressed	express	VERB
bam-5830	540	31	,	,	PUNCT
bam-5830	540	32	conserved	conserve	VERB
bam-5830	540	33	circular	circular	ADJ
bam-5830	540	34	rnas	rna	NOUN
bam-5830	540	35	and	and	CCONJ
bam-5830	540	36	applied	apply	VERB
bam-5830	540	37	a	a	DET
bam-5830	540	38	high	high	ADJ
bam-5830	540	39	-	-	PUNCT
bam-5830	540	40	content	content	NOUN
bam-5830	540	41	functional	functional	ADJ
bam-5830	540	42	genomic	genomic	NOUN
bam-5830	540	43	screen	screen	NOUN
bam-5830	540	44	in	in	ADP
bam-5830	540	45	order	order	NOUN
bam-5830	540	46	to	to	PART
bam-5830	540	47	identify	identify	VERB
bam-5830	540	48	molecules	molecule	NOUN
bam-5830	540	49	that	that	PRON
bam-5830	540	50	were	be	AUX
bam-5830	540	51	able	able	ADJ
bam-5830	540	52	to	to	PART
bam-5830	540	53	impact	impact	VERB
bam-5830	540	54	on	on	ADP
bam-5830	540	55	the	the	DET
bam-5830	540	56	differentiation	differentiation	NOUN
bam-5830	540	57	process	process	NOUN
bam-5830	540	58	.	.	PUNCT
bam-5830	541	1	we	we	PRON
bam-5830	541	2	focused	focus	VERB
bam-5830	541	3	on	on	ADP
bam-5830	541	4	three	three	NUM
bam-5830	541	5	circrnas	circrna	NOUN
bam-5830	541	6	whose	whose	DET
bam-5830	541	7	down	down	ADP
bam-5830	541	8	-	-	PUNCT
bam-5830	541	9	regulation	regulation	NOUN
bam-5830	541	10	resulted	result	VERB
bam-5830	541	11	in	in	ADP
bam-5830	541	12	important	important	ADJ
bam-5830	541	13	phenotypes	phenotype	NOUN
bam-5830	541	14	and	and	CCONJ
bam-5830	541	15	further	far	ADV
bam-5830	541	16	scrutinized	scrutinize	VERB
bam-5830	541	17	one	one	NUM
bam-5830	541	18	of	of	ADP
bam-5830	541	19	them	they	PRON
bam-5830	541	20	,	,	PUNCT
bam-5830	541	21	named	name	VERB
bam-5830	541	22	circ	circ	NOUN
bam-5830	541	23	-	-	PUNCT
bam-5830	541	24	znf609	znf609	PROPN
bam-5830	541	25	,	,	PUNCT
bam-5830	541	26	with	with	ADP
bam-5830	541	27	the	the	DET
bam-5830	541	28	aim	aim	NOUN
bam-5830	541	29	of	of	ADP
bam-5830	541	30	undestanding	undestanding	ADJ
bam-5830	541	31	its	its	PRON
bam-5830	541	32	molecular	molecular	ADJ
bam-5830	541	33	function	function	NOUN
bam-5830	541	34	.	.	PUNCT
bam-5830	542	1	we	we	PRON
bam-5830	542	2	found	find	VERB
bam-5830	542	3	that	that	SCONJ
bam-5830	542	4	circ	circ	NOUN
bam-5830	542	5	-	-	PUNCT
bam-5830	542	6	znf609	znf609	PROPN
bam-5830	542	7	contains	contain	VERB
bam-5830	542	8	an	an	DET
bam-5830	542	9	open	open	ADJ
bam-5830	542	10	reading	reading	NOUN
bam-5830	542	11	frame	frame	NOUN
bam-5830	542	12	spanning	span	VERB
bam-5830	542	13	from	from	ADP
bam-5830	542	14	the	the	DET
bam-5830	542	15	native	native	ADJ
bam-5830	542	16	start	start	NOUN
bam-5830	542	17	codon	codon	NOUN
bam-5830	542	18	of	of	ADP
bam-5830	542	19	its	its	PRON
bam-5830	542	20	host	host	NOUN
bam-5830	542	21	transcript	transcript	NOUN
bam-5830	542	22	and	and	CCONJ
bam-5830	542	23	terminating	terminate	VERB
bam-5830	542	24	at	at	ADP
bam-5830	542	25	an	an	DET
bam-5830	542	26	in	in	ADP
bam-5830	542	27	-	-	PUNCT
bam-5830	542	28	frame	frame	NOUN
bam-5830	542	29	stop	stop	NOUN
bam-5830	542	30	codon	codon	NOUN
bam-5830	542	31	that	that	PRON
bam-5830	542	32	is	be	AUX
bam-5830	542	33	created	create	VERB
bam-5830	542	34	upon	upon	SCONJ
bam-5830	542	35	circularization	circularization	NOUN
bam-5830	542	36	.	.	PUNCT
bam-5830	543	1	circ	circ	NOUN
bam-5830	543	2	-	-	PUNCT
bam-5830	543	3	znf609	znf609	PROPN
bam-5830	543	4	is	be	AUX
bam-5830	543	5	associated	associate	VERB
bam-5830	543	6	to	to	ADP
bam-5830	543	7	heavy	heavy	ADJ
bam-5830	543	8	polysomes	polysome	NOUN
bam-5830	543	9	and	and	CCONJ
bam-5830	543	10	is	be	AUX
bam-5830	543	11	translated	translate	VERB
bam-5830	543	12	into	into	ADP
bam-5830	543	13	a	a	DET
bam-5830	543	14	30kda	30kda	NOUN
bam-5830	543	15	peptide	peptide	NOUN
bam-5830	543	16	that	that	PRON
bam-5830	543	17	is	be	AUX
bam-5830	543	18	able	able	ADJ
bam-5830	543	19	to	to	PART
bam-5830	543	20	promote	promote	VERB
bam-5830	543	21	human	human	ADJ
bam-5830	543	22	myoblasts	myoblast	NOUN
bam-5830	543	23	proliferation	proliferation	NOUN
bam-5830	543	24	.	.	PUNCT
bam-5830	544	1	*	*	PUNCT
bam-5830	544	2	*	*	PUNCT
bam-5830	544	3	*	*	PUNCT
bam-5830	544	4	*	*	PUNCT
bam-5830	544	5	*	*	PUNCT
bam-5830	544	6	*	*	PUNCT
bam-5830	544	7	*	*	PUNCT
bam-5830	544	8	*	*	PUNCT
bam-5830	544	9	*	*	PUNCT
bam-5830	544	10	*	*	PUNCT
bam-5830	544	11	*	*	PUNCT
bam-5830	544	12	*	*	PUNCT
bam-5830	544	13	*	*	PUNCT
bam-5830	544	14	*	*	PUNCT
bam-5830	544	15	*	*	PUNCT
bam-5830	544	16	session	session	NOUN
bam-5830	544	17	6	6	NUM
bam-5830	544	18	.	.	PUNCT
bam-5830	545	1	signalling	signal	VERB
bam-5830	545	2	and	and	CCONJ
bam-5830	545	3	therapeutic	therapeutic	ADJ
bam-5830	545	4	approaches	approach	NOUN
bam-5830	545	5	for	for	ADP
bam-5830	545	6	muscle	muscle	NOUN
bam-5830	545	7	diseases	disease	NOUN
bam-5830	545	8	muscle	muscle	NOUN
bam-5830	545	9	derived	derive	VERB
bam-5830	545	10	pericytes	pericyte	NOUN
bam-5830	545	11	for	for	ADP
bam-5830	545	12	artificial	artificial	ADJ
bam-5830	545	13	skeletal	skeletal	ADJ
bam-5830	545	14	muscle	muscle	NOUN
bam-5830	545	15	human	human	NOUN
bam-5830	545	16	-	-	PUNCT
bam-5830	545	17	like	like	ADJ
bam-5830	545	18	size	size	NOUN
bam-5830	545	19	c.	c.	NOUN
bam-5830	545	20	fuoco	fuoco	PROPN
bam-5830	545	21	,	,	PUNCT
bam-5830	545	22	s.	s.	PROPN
bam-5830	545	23	testa	testa	PROPN
bam-5830	545	24	,	,	PUNCT
bam-5830	545	25	v.	v.	ADP
bam-5830	545	26	bianconi	bianconi	PROPN
bam-5830	545	27	,	,	PUNCT
bam-5830	545	28	l.	l.	PROPN
bam-5830	545	29	l.	l.	PROPN
bam-5830	545	30	petrilli	petrilli	PROPN
bam-5830	545	31	,	,	PUNCT
bam-5830	545	32	s.	s.	PROPN
bam-5830	545	33	bernardini	bernardini	PROPN
bam-5830	545	34	,	,	PUNCT
bam-5830	545	35	s.	s.	PROPN
bam-5830	545	36	cannata	cannata	PROPN
bam-5830	545	37	,	,	PUNCT
bam-5830	545	38	g.	g.	PROPN
bam-5830	545	39	cesareni	cesareni	PROPN
bam-5830	545	40	,	,	PUNCT
bam-5830	545	41	c.	c.	PROPN
bam-5830	545	42	gargioli	gargioli	PROPN
bam-5830	545	43	,	,	PUNCT
bam-5830	545	44	biology	biology	NOUN
bam-5830	545	45	department	department	NOUN
bam-5830	545	46	,	,	PUNCT
bam-5830	545	47	univeristy	univeristy	PROPN
bam-5830	545	48	of	of	ADP
bam-5830	545	49	rome	rome	PROPN
bam-5830	545	50	tor	tor	PROPN
bam-5830	545	51	vergata	vergata	PROPN
bam-5830	545	52	,	,	PUNCT
bam-5830	545	53	italy	italy	PROPN
bam-5830	545	54	e	e	PROPN
bam-5830	545	55	-	-	NOUN
bam-5830	545	56	mail	mail	NOUN
bam-5830	545	57	:	:	PUNCT
bam-5830	545	58	cesare.gargioli@uniroma2.it	cesare.gargioli@uniroma2.it	NOUN
bam-5830	545	59	stem	stem	VERB
bam-5830	545	60	cells	cell	NOUN
bam-5830	545	61	and	and	CCONJ
bam-5830	545	62	regenerative	regenerative	ADJ
bam-5830	545	63	medicine	medicine	NOUN
bam-5830	545	64	have	have	AUX
bam-5830	545	65	greatly	greatly	ADV
bam-5830	545	66	increased	increase	VERB
bam-5830	545	67	the	the	DET
bam-5830	545	68	expectations	expectation	NOUN
bam-5830	545	69	of	of	ADP
bam-5830	545	70	the	the	DET
bam-5830	545	71	scientific	scientific	ADJ
bam-5830	545	72	community	community	NOUN
bam-5830	545	73	and	and	CCONJ
bam-5830	545	74	the	the	DET
bam-5830	545	75	public	public	NOUN
bam-5830	545	76	for	for	ADP
bam-5830	545	77	their	their	PRON
bam-5830	545	78	potential	potential	NOUN
bam-5830	545	79	in	in	ADP
bam-5830	545	80	applications	application	NOUN
bam-5830	545	81	that	that	PRON
bam-5830	545	82	aim	aim	VERB
bam-5830	545	83	at	at	ADP
bam-5830	545	84	recovering	recover	VERB
bam-5830	545	85	or	or	CCONJ
bam-5830	545	86	replacing	replace	VERB
bam-5830	545	87	injured	injure	VERB
bam-5830	545	88	,	,	PUNCT
bam-5830	545	89	aged	aged	ADJ
bam-5830	545	90	and	and	CCONJ
bam-5830	545	91	diseased	diseased	ADJ
bam-5830	545	92	tissues	tissue	NOUN
bam-5830	545	93	.	.	PUNCT
bam-5830	546	1	nevertheless	nevertheless	ADV
bam-5830	546	2	abstracts	abstract	NOUN
bam-5830	546	3	of	of	ADP
bam-5830	546	4	the	the	DET
bam-5830	546	5	xii	xii	PROPN
bam-5830	546	6	iim	iim	NOUN
bam-5830	546	7	myology	myology	NOUN
bam-5830	546	8	meeting	meeting	NOUN
bam-5830	546	9	october	october	PROPN
bam-5830	546	10	1–4	1–4	PROPN
bam-5830	546	11	,	,	PUNCT
bam-5830	546	12	2015	2015	NUM
bam-5830	546	13	eur	eur	PROPN
bam-5830	546	14	j	j	PROPN
bam-5830	546	15	transl	transl	PROPN
bam-5830	546	16	myol	myol	PROPN
bam-5830	546	17	basic	basic	ADJ
bam-5830	546	18	appl	appl	NOUN
bam-5830	546	19	myol	myol	NOUN
bam-5830	546	20	2016	2016	NUM
bam-5830	546	21	;	;	PUNCT
bam-5830	546	22	26	26	NUM
bam-5830	546	23	(	(	PUNCT
bam-5830	546	24	1):2	1):2	NUM
bam-5830	546	25	-	-	SYM
bam-5830	546	26	24	24	NUM
bam-5830	546	27	this	this	DET
bam-5830	546	28	article	article	NOUN
bam-5830	546	29	is	be	AUX
bam-5830	546	30	distributed	distribute	VERB
bam-5830	546	31	under	under	ADP
bam-5830	546	32	the	the	DET
bam-5830	546	33	terms	term	NOUN
bam-5830	546	34	of	of	ADP
bam-5830	546	35	the	the	DET
bam-5830	546	36	creative	creative	ADJ
bam-5830	546	37	commons	common	NOUN
bam-5830	546	38	attribution	attribution	NOUN
bam-5830	546	39	noncommercial	noncommercial	ADJ
bam-5830	546	40	license	license	NOUN
bam-5830	546	41	(	(	PUNCT
bam-5830	546	42	cc	cc	NOUN
bam-5830	546	43	by	by	ADP
bam-5830	546	44	-	-	PUNCT
bam-5830	546	45	nc	nc	PROPN
bam-5830	546	46	4.0	4.0	NUM
bam-5830	546	47	)	)	PUNCT
bam-5830	546	48	which	which	PRON
bam-5830	546	49	permits	permit	VERB
bam-5830	546	50	any	any	DET
bam-5830	546	51	noncommercial	noncommercial	ADJ
bam-5830	546	52	use	use	NOUN
bam-5830	546	53	,	,	PUNCT
bam-5830	546	54	distribution	distribution	NOUN
bam-5830	546	55	,	,	PUNCT
bam-5830	546	56	and	and	CCONJ
bam-5830	546	57	reproduction	reproduction	NOUN
bam-5830	546	58	in	in	ADP
bam-5830	546	59	any	any	DET
bam-5830	546	60	medium	medium	NOUN
bam-5830	546	61	,	,	PUNCT
bam-5830	546	62	provided	provide	VERB
bam-5830	546	63	the	the	DET
bam-5830	546	64	original	original	ADJ
bam-5830	546	65	author(s	author(s	NOUN
bam-5830	546	66	)	)	PUNCT
bam-5830	546	67	and	and	CCONJ
bam-5830	546	68	source	source	NOUN
bam-5830	546	69	are	be	AUX
bam-5830	546	70	credited	credit	VERB
bam-5830	546	71	.	.	PUNCT
bam-5830	547	1	17	17	NUM
bam-5830	547	2	their	their	PRON
bam-5830	547	3	clinical	clinical	ADJ
bam-5830	547	4	application	application	NOUN
bam-5830	547	5	is	be	AUX
bam-5830	547	6	currently	currently	ADV
bam-5830	547	7	hindered	hinder	VERB
bam-5830	547	8	by	by	ADP
bam-5830	547	9	cell	cell	NOUN
bam-5830	547	10	survival	survival	NOUN
bam-5830	547	11	,	,	PUNCT
bam-5830	547	12	inflammatory	inflammatory	ADJ
bam-5830	547	13	response	response	NOUN
bam-5830	547	14	,	,	PUNCT
bam-5830	547	15	tissue	tissue	NOUN
bam-5830	547	16	engraftment	engraftment	NOUN
bam-5830	547	17	,	,	PUNCT
bam-5830	547	18	vascularization	vascularization	NOUN
bam-5830	547	19	and	and	CCONJ
bam-5830	547	20	efficient	efficient	ADJ
bam-5830	547	21	differentiation	differentiation	NOUN
bam-5830	547	22	.	.	PUNCT
bam-5830	548	1	tissue	tissue	NOUN
bam-5830	548	2	engineering	engineering	NOUN
bam-5830	548	3	exploits	exploit	VERB
bam-5830	548	4	biomaterials	biomaterial	NOUN
bam-5830	548	5	to	to	PART
bam-5830	548	6	improve	improve	VERB
bam-5830	548	7	stem	stem	NOUN
bam-5830	548	8	cell	cell	NOUN
bam-5830	548	9	engraftment	engraftment	NOUN
bam-5830	548	10	and	and	CCONJ
bam-5830	548	11	differentiation	differentiation	NOUN
bam-5830	548	12	by	by	ADP
bam-5830	548	13	mimicking	mimic	VERB
bam-5830	548	14	organogenesis	organogenesis	NOUN
bam-5830	548	15	.	.	PUNCT
bam-5830	549	1	skeletal	skeletal	ADJ
bam-5830	549	2	muscle	muscle	NOUN
bam-5830	549	3	tissue	tissue	NOUN
bam-5830	549	4	engineering	engineering	NOUN
bam-5830	549	5	is	be	AUX
bam-5830	549	6	an	an	DET
bam-5830	549	7	up	up	ADV
bam-5830	549	8	-	-	PUNCT
bam-5830	549	9	and	and	CCONJ
bam-5830	549	10	-	-	PUNCT
bam-5830	549	11	coming	come	VERB
bam-5830	549	12	biotechnology	biotechnology	NOUN
bam-5830	549	13	that	that	PRON
bam-5830	549	14	could	could	AUX
bam-5830	549	15	offer	offer	VERB
bam-5830	549	16	great	great	ADJ
bam-5830	549	17	potential	potential	NOUN
bam-5830	549	18	,	,	PUNCT
bam-5830	549	19	in	in	ADP
bam-5830	549	20	the	the	DET
bam-5830	549	21	near	near	ADJ
bam-5830	549	22	future	future	NOUN
bam-5830	549	23	,	,	PUNCT
bam-5830	549	24	for	for	ADP
bam-5830	549	25	muscle	muscle	NOUN
bam-5830	549	26	repair	repair	NOUN
bam-5830	549	27	.	.	PUNCT
bam-5830	550	1	reconstructing	reconstruct	VERB
bam-5830	550	2	the	the	DET
bam-5830	550	3	skeletal	skeletal	ADJ
bam-5830	550	4	muscle	muscle	NOUN
bam-5830	550	5	architecture	architecture	NOUN
bam-5830	550	6	and	and	CCONJ
bam-5830	550	7	function	function	NOUN
bam-5830	550	8	is	be	AUX
bam-5830	550	9	still	still	ADV
bam-5830	550	10	a	a	DET
bam-5830	550	11	challenge	challenge	NOUN
bam-5830	550	12	requiring	require	VERB
bam-5830	550	13	parallel	parallel	ADJ
bam-5830	550	14	alignment	alignment	NOUN
bam-5830	550	15	of	of	ADP
bam-5830	550	16	myofibrils	myofibril	NOUN
bam-5830	550	17	arranged	arrange	VERB
bam-5830	550	18	into	into	ADP
bam-5830	550	19	organized	organized	ADJ
bam-5830	550	20	sarcomeres	sarcomere	NOUN
bam-5830	550	21	.	.	PUNCT
bam-5830	551	1	we	we	PRON
bam-5830	551	2	show	show	VERB
bam-5830	551	3	that	that	SCONJ
bam-5830	551	4	an	an	DET
bam-5830	551	5	"	"	PUNCT
bam-5830	551	6	anatomical	anatomical	ADJ
bam-5830	551	7	bioreactor	bioreactor	NOUN
bam-5830	551	8	-	-	PUNCT
bam-5830	551	9	like	like	NOUN
bam-5830	551	10	"	"	PUNCT
bam-5830	551	11	represented	represent	VERB
bam-5830	551	12	by	by	ADP
bam-5830	551	13	the	the	DET
bam-5830	551	14	surface	surface	NOUN
bam-5830	551	15	of	of	ADP
bam-5830	551	16	mouse	mouse	NOUN
bam-5830	551	17	tibialis	tibialis	PROPN
bam-5830	551	18	anterior	anterior	ADJ
bam-5830	551	19	muscle	muscle	NOUN
bam-5830	551	20	(	(	PUNCT
bam-5830	551	21	ta	ta	NOUN
bam-5830	551	22	)	)	PUNCT
bam-5830	551	23	,	,	PUNCT
bam-5830	551	24	positively	positively	ADV
bam-5830	551	25	influences	influence	VERB
bam-5830	551	26	maturation	maturation	NOUN
bam-5830	551	27	and	and	CCONJ
bam-5830	551	28	alignment	alignment	NOUN
bam-5830	551	29	of	of	ADP
bam-5830	551	30	fibers	fiber	NOUN
bam-5830	551	31	derived	derive	VERB
bam-5830	551	32	from	from	ADP
bam-5830	551	33	adult	adult	NOUN
bam-5830	551	34	muscle	muscle	NOUN
bam-5830	551	35	stem	stem	NOUN
bam-5830	551	36	/	/	SYM
bam-5830	551	37	progenitor	progenitor	NOUN
bam-5830	551	38	cells	cell	NOUN
bam-5830	551	39	embedded	embed	VERB
bam-5830	551	40	into	into	ADP
bam-5830	551	41	a	a	DET
bam-5830	551	42	polyethylene	polyethylene	NOUN
bam-5830	551	43	-	-	PUNCT
bam-5830	551	44	glycol	glycol	NOUN
bam-5830	551	45	-	-	PUNCT
bam-5830	551	46	fibrinogen	fibrinogen	NOUN
bam-5830	551	47	(	(	PUNCT
bam-5830	551	48	pf	pf	NOUN
bam-5830	551	49	)	)	PUNCT
bam-5830	551	50	hydrogel	hydrogel	NOUN
bam-5830	551	51	.	.	PUNCT
bam-5830	552	1	this	this	DET
bam-5830	552	2	approach	approach	NOUN
bam-5830	552	3	leads	lead	VERB
bam-5830	552	4	to	to	ADP
bam-5830	552	5	the	the	DET
bam-5830	552	6	generation	generation	NOUN
bam-5830	552	7	of	of	ADP
bam-5830	552	8	an	an	DET
bam-5830	552	9	artificial	artificial	ADJ
bam-5830	552	10	normal	normal	ADJ
bam-5830	552	11	muscle	muscle	NOUN
bam-5830	552	12	.	.	PUNCT
bam-5830	553	1	furthermore	furthermore	ADV
bam-5830	553	2	by	by	ADP
bam-5830	553	3	the	the	DET
bam-5830	553	4	same	same	ADJ
bam-5830	553	5	approach	approach	NOUN
bam-5830	553	6	we	we	PRON
bam-5830	553	7	succeeded	succeed	VERB
bam-5830	553	8	in	in	ADP
bam-5830	553	9	replacing	replace	VERB
bam-5830	553	10	a	a	DET
bam-5830	553	11	complete	complete	ADJ
bam-5830	553	12	mouse	mouse	NOUN
bam-5830	553	13	ta	ta	NOUN
bam-5830	553	14	after	after	ADP
bam-5830	553	15	massive	massive	ADJ
bam-5830	553	16	muscle	muscle	NOUN
bam-5830	553	17	ablation	ablation	NOUN
bam-5830	553	18	,	,	PUNCT
bam-5830	553	19	recovering	recover	VERB
bam-5830	553	20	morphology	morphology	NOUN
bam-5830	553	21	and	and	CCONJ
bam-5830	553	22	function	function	NOUN
bam-5830	553	23	of	of	ADP
bam-5830	553	24	the	the	DET
bam-5830	553	25	substituting	substitute	VERB
bam-5830	553	26	artificial	artificial	PROPN
bam-5830	553	27	ta	ta	PROPN
bam-5830	553	28	.	.	PUNCT
bam-5830	554	1	starting	start	VERB
bam-5830	554	2	from	from	ADP
bam-5830	554	3	these	these	DET
bam-5830	554	4	observations	observation	NOUN
bam-5830	554	5	,	,	PUNCT
bam-5830	554	6	we	we	PRON
bam-5830	554	7	are	be	AUX
bam-5830	554	8	now	now	ADV
bam-5830	554	9	developing	develop	VERB
bam-5830	554	10	a	a	DET
bam-5830	554	11	novel	novel	ADJ
bam-5830	554	12	approach	approach	NOUN
bam-5830	554	13	for	for	ADP
bam-5830	554	14	regeneration	regeneration	NOUN
bam-5830	554	15	and/or	and/or	CCONJ
bam-5830	554	16	reconstruction	reconstruction	NOUN
bam-5830	554	17	of	of	ADP
bam-5830	554	18	skeletal	skeletal	ADJ
bam-5830	554	19	muscle	muscle	NOUN
bam-5830	554	20	tissue	tissue	NOUN
bam-5830	554	21	segments	segment	NOUN
bam-5830	554	22	human	human	ADJ
bam-5830	554	23	-	-	PUNCT
bam-5830	554	24	like	like	ADJ
bam-5830	554	25	size	size	NOUN
bam-5830	554	26	in	in	ADP
bam-5830	554	27	order	order	NOUN
bam-5830	554	28	to	to	PART
bam-5830	554	29	translate	translate	VERB
bam-5830	554	30	this	this	DET
bam-5830	554	31	technique	technique	NOUN
bam-5830	554	32	to	to	ADP
bam-5830	554	33	clinical	clinical	ADJ
bam-5830	554	34	application	application	NOUN
bam-5830	554	35	.	.	PUNCT
bam-5830	555	1	for	for	ADP
bam-5830	555	2	this	this	DET
bam-5830	555	3	purpose	purpose	NOUN
bam-5830	555	4	human	human	ADJ
bam-5830	555	5	derived	derive	VERB
bam-5830	555	6	muscle	muscle	NOUN
bam-5830	555	7	pericytes	pericyte	NOUN
bam-5830	555	8	have	have	AUX
bam-5830	555	9	been	be	AUX
bam-5830	555	10	isolated	isolate	VERB
bam-5830	555	11	from	from	ADP
bam-5830	555	12	muscle	muscle	NOUN
bam-5830	555	13	biopsies	biopsy	NOUN
bam-5830	555	14	and	and	CCONJ
bam-5830	555	15	have	have	AUX
bam-5830	555	16	been	be	AUX
bam-5830	555	17	investigated	investigate	VERB
bam-5830	555	18	for	for	ADP
bam-5830	555	19	their	their	PRON
bam-5830	555	20	myogenic	myogenic	ADJ
bam-5830	555	21	potential	potential	NOUN
bam-5830	555	22	.	.	PUNCT
bam-5830	556	1	moreover	moreover	ADV
bam-5830	556	2	by	by	ADP
bam-5830	556	3	exploiting	exploit	VERB
bam-5830	556	4	the	the	DET
bam-5830	556	5	pf	pf	PROPN
bam-5830	556	6	properties	property	NOUN
bam-5830	556	7	,	,	PUNCT
bam-5830	556	8	we	we	PRON
bam-5830	556	9	demonstrated	demonstrate	VERB
bam-5830	556	10	the	the	DET
bam-5830	556	11	noteworthy	noteworthy	ADJ
bam-5830	556	12	potential	potential	NOUN
bam-5830	556	13	of	of	ADP
bam-5830	556	14	this	this	DET
bam-5830	556	15	cell	cell	NOUN
bam-5830	556	16	population	population	NOUN
bam-5830	556	17	for	for	ADP
bam-5830	556	18	human	human	ADJ
bam-5830	556	19	skeletal	skeletal	ADJ
bam-5830	556	20	muscle	muscle	NOUN
bam-5830	556	21	tissue	tissue	NOUN
bam-5830	556	22	engineering	engineering	NOUN
bam-5830	556	23	.	.	PUNCT
bam-5830	557	1	*	*	PUNCT
bam-5830	557	2	*	*	PUNCT
bam-5830	557	3	*	*	PUNCT
bam-5830	557	4	*	*	PUNCT
bam-5830	557	5	*	*	NOUN
bam-5830	557	6	effects	effect	NOUN
bam-5830	557	7	of	of	ADP
bam-5830	557	8	the	the	DET
bam-5830	557	9	hdaci	hdaci	NOUN
bam-5830	557	10	givinostat	givinostat	NOUN
bam-5830	557	11	on	on	ADP
bam-5830	557	12	muscle	muscle	NOUN
bam-5830	557	13	regeneration	regeneration	NOUN
bam-5830	557	14	of	of	ADP
bam-5830	557	15	mdx	mdx	NOUN
bam-5830	557	16	mice	mice	NOUN
bam-5830	557	17	a.	a.	NOUN
bam-5830	557	18	torcinaro	torcinaro	PROPN
bam-5830	557	19	1	1	NUM
bam-5830	557	20	,	,	PUNCT
bam-5830	557	21	l.	l.	PROPN
bam-5830	557	22	madaro	madaro	PROPN
bam-5830	557	23	1,2	1,2	NUM
bam-5830	557	24	,	,	PUNCT
bam-5830	557	25	f.	f.	PROPN
bam-5830	557	26	de	de	PROPN
bam-5830	557	27	santa	santa	PROPN
bam-5830	557	28	1	1	NUM
bam-5830	557	29	1	1	NUM
bam-5830	557	30	.	.	PUNCT
bam-5830	558	1	institute	institute	PROPN
bam-5830	558	2	of	of	ADP
bam-5830	558	3	cell	cell	NOUN
bam-5830	558	4	biology	biology	NOUN
bam-5830	558	5	and	and	CCONJ
bam-5830	558	6	neurobiology	neurobiology	NOUN
bam-5830	558	7	(	(	PUNCT
bam-5830	558	8	ibcn	ibcn	PROPN
bam-5830	558	9	)	)	PUNCT
bam-5830	558	10	,	,	PUNCT
bam-5830	558	11	national	national	PROPN
bam-5830	558	12	council	council	PROPN
bam-5830	558	13	of	of	ADP
bam-5830	558	14	research	research	PROPN
bam-5830	558	15	(	(	PUNCT
bam-5830	558	16	cnr	cnr	PROPN
bam-5830	558	17	)	)	PUNCT
bam-5830	558	18	,	,	PUNCT
bam-5830	558	19	rome	rome	PROPN
bam-5830	558	20	,	,	PUNCT
bam-5830	558	21	italy	italy	PROPN
bam-5830	558	22	;	;	PUNCT
bam-5830	558	23	2	2	X
bam-5830	558	24	.	.	PUNCT
bam-5830	558	25	epigenetics	epigenetic	NOUN
bam-5830	558	26	and	and	CCONJ
bam-5830	558	27	regenerative	regenerative	ADJ
bam-5830	558	28	medicine	medicine	NOUN
bam-5830	558	29	,	,	PUNCT
bam-5830	558	30	irccs	ircc	VERB
bam-5830	558	31	fondazione	fondazione	PROPN
bam-5830	558	32	santa	santa	PROPN
bam-5830	558	33	lucia	lucia	PROPN
bam-5830	558	34	,	,	PUNCT
bam-5830	558	35	rome	rome	PROPN
bam-5830	558	36	,	,	PUNCT
bam-5830	558	37	italy	italy	PROPN
bam-5830	558	38	e	e	PROPN
bam-5830	558	39	-	-	NOUN
bam-5830	558	40	mail	mail	NOUN
bam-5830	558	41	:	:	PUNCT
bam-5830	558	42	alessio.torcinaro@libero.it	alessio.torcinaro@libero.it	PROPN
bam-5830	558	43	histone	histone	NOUN
bam-5830	558	44	deacetylases	deacetylase	NOUN
bam-5830	558	45	(	(	PUNCT
bam-5830	558	46	hdacs	hdac	NOUN
bam-5830	558	47	)	)	PUNCT
bam-5830	558	48	control	control	VERB
bam-5830	558	49	the	the	DET
bam-5830	558	50	transcriptional	transcriptional	NOUN
bam-5830	558	51	networks	network	NOUN
bam-5830	558	52	underlying	underlie	VERB
bam-5830	558	53	both	both	DET
bam-5830	558	54	muscle	muscle	NOUN
bam-5830	558	55	differentiation	differentiation	NOUN
bam-5830	558	56	and	and	CCONJ
bam-5830	558	57	progression	progression	NOUN
bam-5830	558	58	of	of	ADP
bam-5830	558	59	dystrophy	dystrophy	NOUN
bam-5830	558	60	.	.	PUNCT
bam-5830	559	1	considering	consider	VERB
bam-5830	559	2	that	that	PRON
bam-5830	559	3	,	,	PUNCT
bam-5830	559	4	hdac	hdac	NOUN
bam-5830	559	5	inhibitors	inhibitor	NOUN
bam-5830	559	6	(	(	PUNCT
bam-5830	559	7	hdaci	hdaci	NOUN
bam-5830	559	8	)	)	PUNCT
bam-5830	559	9	are	be	AUX
bam-5830	559	10	important	important	ADJ
bam-5830	559	11	candidate	candidate	NOUN
bam-5830	559	12	drugs	drug	NOUN
bam-5830	559	13	for	for	ADP
bam-5830	559	14	pharmacological	pharmacological	ADJ
bam-5830	559	15	interventions	intervention	NOUN
bam-5830	559	16	in	in	ADP
bam-5830	559	17	muscular	muscular	ADJ
bam-5830	559	18	dystrophies	dystrophy	NOUN
bam-5830	559	19	.	.	PUNCT
bam-5830	560	1	although	although	SCONJ
bam-5830	560	2	the	the	DET
bam-5830	560	3	beneficial	beneficial	ADJ
bam-5830	560	4	effects	effect	NOUN
bam-5830	560	5	of	of	ADP
bam-5830	560	6	hdaci	hdaci	NOUN
bam-5830	560	7	in	in	ADP
bam-5830	560	8	the	the	DET
bam-5830	560	9	treatment	treatment	NOUN
bam-5830	560	10	of	of	ADP
bam-5830	560	11	muscular	muscular	ADJ
bam-5830	560	12	dystrophy	dystrophy	NOUN
bam-5830	560	13	are	be	AUX
bam-5830	560	14	known	know	VERB
bam-5830	560	15	,	,	PUNCT
bam-5830	560	16	it	it	PRON
bam-5830	560	17	remains	remain	VERB
bam-5830	560	18	to	to	PART
bam-5830	560	19	dissect	dissect	VERB
bam-5830	560	20	the	the	DET
bam-5830	560	21	mechanism	mechanism	NOUN
bam-5830	560	22	of	of	ADP
bam-5830	560	23	action	action	NOUN
bam-5830	560	24	and	and	CCONJ
bam-5830	560	25	the	the	DET
bam-5830	560	26	cellular	cellular	ADJ
bam-5830	560	27	mediators	mediator	NOUN
bam-5830	560	28	of	of	ADP
bam-5830	560	29	these	these	DET
bam-5830	560	30	drugs	drug	NOUN
bam-5830	560	31	.	.	PUNCT
bam-5830	561	1	the	the	DET
bam-5830	561	2	goal	goal	NOUN
bam-5830	561	3	of	of	ADP
bam-5830	561	4	this	this	DET
bam-5830	561	5	project	project	NOUN
bam-5830	561	6	is	be	AUX
bam-5830	561	7	to	to	PART
bam-5830	561	8	analyze	analyze	VERB
bam-5830	561	9	the	the	DET
bam-5830	561	10	molecular	molecular	ADJ
bam-5830	561	11	mechanisms	mechanism	NOUN
bam-5830	561	12	underlying	underlie	VERB
bam-5830	561	13	the	the	DET
bam-5830	561	14	role	role	NOUN
bam-5830	561	15	of	of	ADP
bam-5830	561	16	resident	resident	ADJ
bam-5830	561	17	satellite	satellite	NOUN
bam-5830	561	18	cells	cell	NOUN
bam-5830	561	19	and	and	CCONJ
bam-5830	561	20	infiltrating	infiltrate	VERB
bam-5830	561	21	macrophages	macrophage	NOUN
bam-5830	561	22	in	in	ADP
bam-5830	561	23	mediating	mediate	VERB
bam-5830	561	24	the	the	DET
bam-5830	561	25	activity	activity	NOUN
bam-5830	561	26	of	of	ADP
bam-5830	561	27	hdaci	hdaci	NOUN
bam-5830	561	28	itf2357	itf2357	VERB
bam-5830	561	29	(	(	PUNCT
bam-5830	561	30	also	also	ADV
bam-5830	561	31	referred	refer	VERB
bam-5830	561	32	to	to	ADP
bam-5830	561	33	as	as	ADP
bam-5830	561	34	givinostat	givinostat	NOUN
bam-5830	561	35	)	)	PUNCT
bam-5830	561	36	in	in	ADP
bam-5830	561	37	dystrophic	dystrophic	ADJ
bam-5830	561	38	muscle	muscle	NOUN
bam-5830	561	39	of	of	ADP
bam-5830	561	40	mdx	mdx	NOUN
bam-5830	561	41	mice	mouse	NOUN
bam-5830	561	42	,	,	PUNCT
bam-5830	561	43	the	the	DET
bam-5830	561	44	best	good	ADJ
bam-5830	561	45	animal	animal	NOUN
bam-5830	561	46	model	model	NOUN
bam-5830	561	47	of	of	ADP
bam-5830	561	48	duchenne	duchenne	PROPN
bam-5830	561	49	muscular	muscular	ADJ
bam-5830	561	50	dystrophy	dystrophy	NOUN
bam-5830	561	51	(	(	PUNCT
bam-5830	561	52	dmd	dmd	NOUN
bam-5830	561	53	)	)	PUNCT
bam-5830	561	54	.	.	PUNCT
bam-5830	562	1	we	we	PRON
bam-5830	562	2	analyzed	analyze	VERB
bam-5830	562	3	the	the	DET
bam-5830	562	4	dystrophic	dystrophic	ADJ
bam-5830	562	5	phenotype	phenotype	NOUN
bam-5830	562	6	of	of	ADP
bam-5830	562	7	mdx	mdx	NOUN
bam-5830	562	8	mice	mouse	NOUN
bam-5830	562	9	treated	treat	VERB
bam-5830	562	10	with	with	ADP
bam-5830	562	11	givinostat	givinostat	NOUN
bam-5830	562	12	at	at	ADP
bam-5830	562	13	different	different	ADJ
bam-5830	562	14	stages	stage	NOUN
bam-5830	562	15	of	of	ADP
bam-5830	562	16	disease	disease	NOUN
bam-5830	562	17	,	,	PUNCT
bam-5830	562	18	specifically	specifically	ADV
bam-5830	562	19	6	6	NUM
bam-5830	562	20	,	,	PUNCT
bam-5830	562	21	12	12	NUM
bam-5830	562	22	and	and	CCONJ
bam-5830	562	23	36	36	NUM
bam-5830	562	24	weeks	week	NOUN
bam-5830	562	25	,	,	PUNCT
bam-5830	562	26	corresponding	correspond	VERB
bam-5830	562	27	to	to	ADP
bam-5830	562	28	necrotic	necrotic	ADJ
bam-5830	562	29	/	/	SYM
bam-5830	562	30	inflammatory	inflammatory	ADJ
bam-5830	562	31	,	,	PUNCT
bam-5830	562	32	regenerative	regenerative	ADJ
bam-5830	562	33	and	and	CCONJ
bam-5830	562	34	fibrotic	fibrotic	ADJ
bam-5830	562	35	stage	stage	NOUN
bam-5830	562	36	,	,	PUNCT
bam-5830	562	37	respectively	respectively	ADV
bam-5830	562	38	.	.	PUNCT
bam-5830	563	1	the	the	DET
bam-5830	563	2	histopathological	histopathological	ADJ
bam-5830	563	3	and	and	CCONJ
bam-5830	563	4	morphometric	morphometric	ADJ
bam-5830	563	5	analyses	analysis	NOUN
bam-5830	563	6	show	show	VERB
bam-5830	563	7	an	an	DET
bam-5830	563	8	amelioration	amelioration	NOUN
bam-5830	563	9	of	of	ADP
bam-5830	563	10	dystrophic	dystrophic	ADJ
bam-5830	563	11	phenotype	phenotype	NOUN
bam-5830	563	12	with	with	ADP
bam-5830	563	13	a	a	DET
bam-5830	563	14	significant	significant	ADJ
bam-5830	563	15	increase	increase	NOUN
bam-5830	563	16	of	of	ADP
bam-5830	563	17	muscle	muscle	NOUN
bam-5830	563	18	fiber	fiber	NOUN
bam-5830	563	19	cross	cross	ADJ
bam-5830	563	20	-	-	ADJ
bam-5830	563	21	sectional	sectional	ADJ
bam-5830	563	22	area	area	NOUN
bam-5830	563	23	and	and	CCONJ
bam-5830	563	24	a	a	DET
bam-5830	563	25	consistent	consistent	ADJ
bam-5830	563	26	reduction	reduction	NOUN
bam-5830	563	27	of	of	ADP
bam-5830	563	28	intramuscular	intramuscular	ADJ
bam-5830	563	29	fibrosis	fibrosis	NOUN
bam-5830	563	30	,	,	PUNCT
bam-5830	563	31	surprisingly	surprisingly	ADV
bam-5830	563	32	also	also	ADV
bam-5830	563	33	at	at	ADP
bam-5830	563	34	late	late	ADJ
bam-5830	563	35	stage	stage	NOUN
bam-5830	563	36	of	of	ADP
bam-5830	563	37	disease	disease	NOUN
bam-5830	563	38	,	,	PUNCT
bam-5830	563	39	suggest	suggest	VERB
bam-5830	563	40	a	a	DET
bam-5830	563	41	positive	positive	ADJ
bam-5830	563	42	outcome	outcome	NOUN
bam-5830	563	43	also	also	ADV
bam-5830	563	44	in	in	ADP
bam-5830	563	45	old	old	ADJ
bam-5830	563	46	mdx	mdx	NOUN
bam-5830	563	47	mice	mouse	NOUN
bam-5830	563	48	.	.	PUNCT
bam-5830	564	1	moreover	moreover	ADV
bam-5830	564	2	,	,	PUNCT
bam-5830	564	3	gene	gene	NOUN
bam-5830	564	4	expression	expression	NOUN
bam-5830	564	5	analysis	analysis	NOUN
bam-5830	564	6	of	of	ADP
bam-5830	564	7	whole	whole	ADJ
bam-5830	564	8	skeletal	skeletal	ADJ
bam-5830	564	9	muscle	muscle	NOUN
bam-5830	564	10	and	and	CCONJ
bam-5830	564	11	purified	purified	ADJ
bam-5830	564	12	cell	cell	NOUN
bam-5830	564	13	populations	population	NOUN
bam-5830	564	14	pointed	point	VERB
bam-5830	564	15	out	out	ADP
bam-5830	564	16	a	a	DET
bam-5830	564	17	modulation	modulation	NOUN
bam-5830	564	18	of	of	ADP
bam-5830	564	19	fibrosis	fibrosis	NOUN
bam-5830	564	20	and	and	CCONJ
bam-5830	564	21	inflammatory	inflammatory	ADJ
bam-5830	564	22	markers	marker	NOUN
bam-5830	564	23	and	and	CCONJ
bam-5830	564	24	fibroadipogenic	fibroadipogenic	ADJ
bam-5830	564	25	differentiation	differentiation	NOUN
bam-5830	564	26	.	.	PUNCT
bam-5830	565	1	overall	overall	ADV
bam-5830	565	2	,	,	PUNCT
bam-5830	565	3	these	these	DET
bam-5830	565	4	data	datum	NOUN
bam-5830	565	5	confirm	confirm	VERB
bam-5830	565	6	the	the	DET
bam-5830	565	7	beneficial	beneficial	ADJ
bam-5830	565	8	effects	effect	NOUN
bam-5830	565	9	of	of	ADP
bam-5830	565	10	givinostat	givinostat	NOUN
bam-5830	565	11	on	on	ADP
bam-5830	565	12	dystrophic	dystrophic	ADJ
bam-5830	565	13	muscle	muscle	NOUN
bam-5830	565	14	and	and	CCONJ
bam-5830	565	15	identify	identify	VERB
bam-5830	565	16	the	the	DET
bam-5830	565	17	involvement	involvement	NOUN
bam-5830	565	18	of	of	ADP
bam-5830	565	19	macrophages	macrophage	NOUN
bam-5830	565	20	in	in	ADP
bam-5830	565	21	mediating	mediate	VERB
bam-5830	565	22	givinostat	givinostat	ADJ
bam-5830	565	23	activity	activity	NOUN
bam-5830	565	24	.	.	PUNCT
bam-5830	566	1	*	*	PUNCT
bam-5830	566	2	*	*	PUNCT
bam-5830	566	3	*	*	PUNCT
bam-5830	566	4	*	*	PUNCT
bam-5830	566	5	*	*	PUNCT
bam-5830	566	6	an	an	DET
bam-5830	566	7	anti	anti	ADJ
bam-5830	566	8	-	-	ADJ
bam-5830	566	9	oxidant	oxidant	ADJ
bam-5830	566	10	treatment	treatment	NOUN
bam-5830	566	11	(	(	PUNCT
bam-5830	566	12	nac	nac	NOUN
bam-5830	566	13	)	)	PUNCT
bam-5830	566	14	reduces	reduce	VERB
bam-5830	566	15	formation	formation	NOUN
bam-5830	566	16	of	of	ADP
bam-5830	566	17	cores	core	NOUN
bam-5830	566	18	and	and	CCONJ
bam-5830	566	19	improves	improve	VERB
bam-5830	566	20	muscle	muscle	NOUN
bam-5830	566	21	function	function	NOUN
bam-5830	566	22	in	in	ADP
bam-5830	566	23	ryr1y522s	ryr1y522s	NOUN
bam-5830	566	24	/	/	SYM
bam-5830	566	25	wt	wt	NOUN
bam-5830	566	26	mice	mice	NOUN
bam-5830	566	27	a.	a.	PROPN
bam-5830	566	28	de	de	PROPN
bam-5830	566	29	marco	marco	PROPN
bam-5830	566	30	1	1	NUM
bam-5830	566	31	,	,	PUNCT
bam-5830	566	32	a.	a.	NOUN
bam-5830	566	33	michelucci	michelucci	NOUN
bam-5830	566	34	1	1	NUM
bam-5830	566	35	,	,	PUNCT
bam-5830	566	36	s.	s.	PROPN
bam-5830	566	37	l.	l.	PROPN
bam-5830	566	38	hamilton	hamilton	PROPN
bam-5830	566	39	2	2	PROPN
bam-5830	566	40	,	,	PUNCT
bam-5830	566	41	s.	s.	PROPN
bam-5830	566	42	boncompagni	boncompagni	PROPN
bam-5830	566	43	1	1	NUM
bam-5830	566	44	,	,	PUNCT
bam-5830	566	45	f.	f.	PROPN
bam-5830	566	46	protasi	protasi	PROPN
bam-5830	566	47	1	1	NUM
bam-5830	566	48	1	1	NUM
bam-5830	566	49	.	.	PUNCT
bam-5830	567	1	cesi	cesi	PROPN
bam-5830	567	2	center	center	PROPN
bam-5830	567	3	for	for	ADP
bam-5830	567	4	research	research	NOUN
bam-5830	567	5	on	on	ADP
bam-5830	567	6	ageing	ageing	NOUN
bam-5830	567	7	&	&	CCONJ
bam-5830	567	8	dnics	dnic	NOUN
bam-5830	567	9	–	–	PUNCT
bam-5830	567	10	dept	dept	NOUN
bam-5830	567	11	.	.	PROPN
bam-5830	567	12	neuroscience	neuroscience	PROPN
bam-5830	567	13	,	,	PUNCT
bam-5830	567	14	imaging	imaging	NOUN
bam-5830	567	15	,	,	PUNCT
bam-5830	567	16	and	and	CCONJ
bam-5830	567	17	clinical	clinical	ADJ
bam-5830	567	18	sciences	science	NOUN
bam-5830	567	19	;	;	PUNCT
bam-5830	567	20	university	university	NOUN
bam-5830	567	21	g.	g.	PROPN
bam-5830	567	22	d’annunzio	d’annunzio	PROPN
bam-5830	567	23	of	of	ADP
bam-5830	567	24	chieti	chieti	PROPN
bam-5830	567	25	,	,	PUNCT
bam-5830	567	26	italy	italy	PROPN
bam-5830	567	27	;	;	PUNCT
bam-5830	567	28	2	2	X
bam-5830	567	29	.	.	X
bam-5830	567	30	dept	dept	NOUN
bam-5830	567	31	.	.	PROPN
bam-5830	568	1	of	of	ADP
bam-5830	568	2	molecular	molecular	ADJ
bam-5830	568	3	physiology	physiology	NOUN
bam-5830	568	4	and	and	CCONJ
bam-5830	568	5	biophysics	biophysic	NOUN
bam-5830	568	6	,	,	PUNCT
bam-5830	568	7	baylor	baylor	PROPN
bam-5830	568	8	college	college	PROPN
bam-5830	568	9	of	of	ADP
bam-5830	568	10	medicine	medicine	NOUN
bam-5830	568	11	,	,	PUNCT
bam-5830	568	12	houston	houston	PROPN
bam-5830	568	13	,	,	PUNCT
bam-5830	568	14	usa	usa	PROPN
bam-5830	568	15	e	e	PROPN
bam-5830	568	16	-	-	NOUN
bam-5830	568	17	mail	mail	NOUN
bam-5830	568	18	:	:	PUNCT
bam-5830	568	19	alessandro.demarco@outlook.com	alessandro.demarco@outlook.com	PROPN
bam-5830	568	20	central	central	ADJ
bam-5830	568	21	core	core	NOUN
bam-5830	568	22	disease	disease	NOUN
bam-5830	568	23	(	(	PUNCT
bam-5830	568	24	ccd	ccd	NOUN
bam-5830	568	25	)	)	PUNCT
bam-5830	568	26	and	and	CCONJ
bam-5830	568	27	malignant	malignant	ADJ
bam-5830	568	28	hyperthermia	hyperthermia	NOUN
bam-5830	568	29	(	(	PUNCT
bam-5830	568	30	mh	mh	PROPN
bam-5830	568	31	)	)	PUNCT
bam-5830	568	32	are	be	AUX
bam-5830	568	33	related	relate	VERB
bam-5830	568	34	disorders	disorder	NOUN
bam-5830	568	35	linked	link	VERB
bam-5830	568	36	to	to	ADP
bam-5830	568	37	mutations	mutation	NOUN
bam-5830	568	38	in	in	ADP
bam-5830	568	39	the	the	DET
bam-5830	568	40	ryanodine	ryanodine	NOUN
bam-5830	568	41	receptopr-1	receptopr-1	NUM
bam-5830	568	42	(	(	PUNCT
bam-5830	568	43	ryr1	ryr1	NOUN
bam-5830	568	44	)	)	PUNCT
bam-5830	568	45	gene	gene	NOUN
bam-5830	568	46	,	,	PUNCT
bam-5830	568	47	encoding	encode	VERB
bam-5830	568	48	for	for	ADP
bam-5830	568	49	the	the	DET
bam-5830	568	50	sarcoplasmic	sarcoplasmic	ADJ
bam-5830	568	51	reticulum	reticulum	NOUN
bam-5830	568	52	(	(	PUNCT
bam-5830	568	53	sr	sr	PROPN
bam-5830	568	54	)	)	PUNCT
bam-5830	568	55	ca2	ca2	PROPN
bam-5830	568	56	+	+	PROPN
bam-5830	568	57	release	release	NOUN
bam-5830	568	58	channel	channel	NOUN
bam-5830	568	59	.	.	PUNCT
bam-5830	569	1	ccd	ccd	PROPN
bam-5830	569	2	is	be	AUX
bam-5830	569	3	a	a	DET
bam-5830	569	4	congenital	congenital	ADJ
bam-5830	569	5	myopathy	myopathy	NOUN
bam-5830	569	6	characterized	characterize	VERB
bam-5830	569	7	by	by	ADP
bam-5830	569	8	amorphous	amorphous	ADJ
bam-5830	569	9	regions	region	NOUN
bam-5830	569	10	lacking	lack	VERB
bam-5830	569	11	mitochondrial	mitochondrial	ADJ
bam-5830	569	12	activity	activity	NOUN
bam-5830	569	13	(	(	PUNCT
bam-5830	569	14	cores	core	NOUN
bam-5830	569	15	)	)	PUNCT
bam-5830	569	16	in	in	ADP
bam-5830	569	17	skeletal	skeletal	ADJ
bam-5830	569	18	fibers	fiber	NOUN
bam-5830	569	19	.	.	PUNCT
bam-5830	570	1	in	in	ADP
bam-5830	570	2	humans	human	NOUN
bam-5830	570	3	,	,	PUNCT
bam-5830	570	4	the	the	DET
bam-5830	570	5	ryr1	ryr1	PROPN
bam-5830	570	6	-	-	PUNCT
bam-5830	570	7	y522s	y522s	PROPN
bam-5830	570	8	mutation	mutation	NOUN
bam-5830	570	9	is	be	AUX
bam-5830	570	10	associated	associate	VERB
bam-5830	570	11	with	with	ADP
bam-5830	570	12	mh	mh	PROPN
bam-5830	570	13	and	and	CCONJ
bam-5830	570	14	formation	formation	NOUN
bam-5830	570	15	of	of	ADP
bam-5830	570	16	structural	structural	ADJ
bam-5830	570	17	cores	core	NOUN
bam-5830	570	18	.	.	PUNCT
bam-5830	571	1	skeletal	skeletal	ADJ
bam-5830	571	2	fibers	fiber	NOUN
bam-5830	571	3	of	of	ADP
bam-5830	571	4	knock	knock	NOUN
bam-5830	571	5	-	-	PUNCT
bam-5830	571	6	in	in	ADP
bam-5830	571	7	ryr1y522s	ryr1y522s	NOUN
bam-5830	571	8	/	/	SYM
bam-5830	571	9	wt	wt	NOUN
bam-5830	571	10	mice	mouse	NOUN
bam-5830	571	11	develop	develop	VERB
bam-5830	571	12	mitochondrial	mitochondrial	ADJ
bam-5830	571	13	damage	damage	NOUN
bam-5830	571	14	and	and	CCONJ
bam-5830	571	15	cores	core	NOUN
bam-5830	571	16	,	,	PUNCT
bam-5830	571	17	caused	cause	VERB
bam-5830	571	18	by	by	ADP
bam-5830	571	19	excessive	excessive	ADJ
bam-5830	571	20	oxidative	oxidative	ADJ
bam-5830	571	21	stress	stress	NOUN
bam-5830	571	22	(	(	PUNCT
bam-5830	571	23	boncompagni	boncompagni	NOUN
bam-5830	571	24	et	et	PROPN
bam-5830	571	25	al	al	PROPN
bam-5830	571	26	.	.	PROPN
bam-5830	571	27	2009	2009	NUM
bam-5830	571	28	pnas	pna	NOUN
bam-5830	571	29	)	)	PUNCT
bam-5830	571	30	.	.	PUNCT
bam-5830	572	1	we	we	PRON
bam-5830	572	2	treated	treat	VERB
bam-5830	572	3	ryr1y522s	ryr1y522s	NOUN
bam-5830	572	4	/	/	SYM
bam-5830	572	5	wt	wt	NOUN
bam-5830	572	6	mice	mouse	NOUN
bam-5830	572	7	with	with	ADP
bam-5830	572	8	an	an	DET
bam-5830	572	9	antioxidant	antioxidant	ADJ
bam-5830	572	10	,	,	PUNCT
bam-5830	572	11	n	n	CCONJ
bam-5830	572	12	-	-	PUNCT
bam-5830	572	13	acetylcysteine	acetylcysteine	NOUN
bam-5830	572	14	(	(	PUNCT
bam-5830	572	15	nac	nac	PROPN
bam-5830	572	16	)	)	PUNCT
bam-5830	572	17	,	,	PUNCT
bam-5830	572	18	provided	provide	VERB
bam-5830	572	19	ad	ad	NOUN
bam-5830	572	20	-	-	PUNCT
bam-5830	572	21	libitum	libitum	NOUN
bam-5830	572	22	in	in	ADP
bam-5830	572	23	drinking	drinking	NOUN
bam-5830	572	24	water	water	NOUN
bam-5830	572	25	(	(	PUNCT
bam-5830	572	26	1%w	1%w	PROPN
bam-5830	572	27	/	/	SYM
bam-5830	572	28	v	v	NOUN
bam-5830	572	29	)	)	PUNCT
bam-5830	572	30	for	for	ADP
bam-5830	572	31	2	2	NUM
bam-5830	572	32	months	month	NOUN
bam-5830	572	33	and	and	CCONJ
bam-5830	572	34	verified	verify	VERB
bam-5830	572	35	reduction	reduction	NOUN
bam-5830	572	36	of	of	ADP
bam-5830	572	37	oxidative	oxidative	ADJ
bam-5830	572	38	stress	stress	NOUN
bam-5830	572	39	:	:	PUNCT
bam-5830	572	40	indeed	indeed	ADV
bam-5830	572	41	,	,	PUNCT
bam-5830	572	42	level	level	NOUN
bam-5830	572	43	of	of	ADP
bam-5830	572	44	3	3	NUM
bam-5830	572	45	-	-	PUNCT
bam-5830	572	46	nitrotyrosine	nitrotyrosine	NOUN
bam-5830	572	47	was	be	AUX
bam-5830	572	48	increased	increase	VERB
bam-5830	572	49	by	by	ADP
bam-5830	572	50	1.44	1.44	NUM
bam-5830	572	51	-	-	PUNCT
bam-5830	572	52	folds	fold	NOUN
bam-5830	572	53	in	in	ADP
bam-5830	572	54	ryr1y522s	ryr1y522s	NOUN
bam-5830	572	55	/	/	SYM
bam-5830	572	56	wt	wt	NOUN
bam-5830	572	57	mice	mouse	NOUN
bam-5830	572	58	,	,	PUNCT
bam-5830	572	59	but	but	CCONJ
bam-5830	572	60	reduced	reduce	VERB
bam-5830	572	61	to	to	PART
bam-5830	572	62	control	control	VERB
bam-5830	572	63	levels	level	NOUN
bam-5830	572	64	after	after	ADP
bam-5830	572	65	nac	nac	PROPN
bam-5830	572	66	treatment	treatment	PROPN
bam-5830	572	67	.	.	PUNCT
bam-5830	573	1	electron	electron	NOUN
bam-5830	573	2	microscopy	microscopy	NOUN
bam-5830	573	3	was	be	AUX
bam-5830	573	4	used	use	VERB
bam-5830	573	5	to	to	PART
bam-5830	573	6	assess	assess	VERB
bam-5830	573	7	mitochondrial	mitochondrial	ADJ
bam-5830	573	8	integrity	integrity	NOUN
bam-5830	573	9	following	follow	VERB
bam-5830	573	10	nactreatment	nactreatment	NOUN
bam-5830	573	11	:	:	PUNCT
bam-5830	573	12	a	a	X
bam-5830	573	13	)	)	PUNCT
bam-5830	573	14	mitochondria	mitochondria	NOUN
bam-5830	573	15	swelling	swelling	NOUN
bam-5830	573	16	and	and	CCONJ
bam-5830	573	17	frequency	frequency	NOUN
bam-5830	573	18	of	of	ADP
bam-5830	573	19	damaged	damage	VERB
bam-5830	573	20	mitochondria	mitochondria	NOUN
bam-5830	573	21	were	be	AUX
bam-5830	573	22	both	both	PRON
bam-5830	573	23	decreased	decrease	VERB
bam-5830	573	24	(	(	PUNCT
bam-5830	573	25	-24	-24	NOUN
bam-5830	573	26	%	%	NOUN
bam-5830	573	27	and	and	CCONJ
bam-5830	573	28	-10	-10	NUM
bam-5830	573	29	%	%	NOUN
bam-5830	573	30	,	,	PUNCT
bam-5830	573	31	respectively	respectively	ADV
bam-5830	573	32	)	)	PUNCT
bam-5830	573	33	;	;	PUNCT
bam-5830	573	34	b	b	X
bam-5830	573	35	)	)	PUNCT
bam-5830	573	36	the	the	DET
bam-5830	573	37	number/100	number/100	NOUN
bam-5830	573	38	m2	m2	PROPN
bam-5830	573	39	of	of	ADP
bam-5830	573	40	mitochondria	mitochondria	NOUN
bam-5830	573	41	(	(	PUNCT
bam-5830	573	42	25.9	25.9	NUM
bam-5830	573	43	±	±	NUM
bam-5830	573	44	0.7	0.7	NUM
bam-5830	573	45	vs	vs	ADP
bam-5830	573	46	29.1	29.1	NUM
bam-5830	573	47	±	±	NUM
bam-5830	573	48	0.6	0.6	NUM
bam-5830	573	49	)	)	PUNCT
bam-5830	573	50	and	and	CCONJ
bam-5830	573	51	their	their	PRON
bam-5830	573	52	proper	proper	ADJ
bam-5830	573	53	association	association	NOUN
bam-5830	573	54	with	with	ADP
bam-5830	573	55	the	the	DET
bam-5830	573	56	sr	sr	PROPN
bam-5830	573	57	(	(	PUNCT
bam-5830	573	58	+22	+22	PROPN
bam-5830	573	59	%	%	NOUN
bam-5830	573	60	)	)	PUNCT
bam-5830	573	61	were	be	AUX
bam-5830	573	62	both	both	PRON
bam-5830	573	63	increased	increase	VERB
bam-5830	573	64	.	.	PUNCT
bam-5830	574	1	using	use	VERB
bam-5830	574	2	histological	histological	ADJ
bam-5830	574	3	analysis	analysis	NOUN
bam-5830	574	4	,	,	PUNCT
bam-5830	574	5	we	we	PRON
bam-5830	574	6	also	also	ADV
bam-5830	574	7	verified	verify	VERB
bam-5830	574	8	that	that	SCONJ
bam-5830	574	9	nac	nac	PROPN
bam-5830	574	10	was	be	AUX
bam-5830	574	11	effective	effective	ADJ
bam-5830	574	12	in	in	ADP
bam-5830	574	13	reducing	reduce	VERB
bam-5830	574	14	the	the	DET
bam-5830	574	15	frequency	frequency	NOUN
bam-5830	574	16	of	of	ADP
bam-5830	574	17	cores	core	NOUN
bam-5830	574	18	(	(	PUNCT
bam-5830	574	19	-20	-20	NUM
bam-5830	574	20	%	%	NOUN
bam-5830	574	21	contracture	contracture	NOUN
bam-5830	574	22	cores	core	NOUN
bam-5830	574	23	;	;	PUNCT
bam-5830	574	24	-30	-30	NUM
bam-5830	574	25	%	%	NOUN
bam-5830	574	26	unstructured	unstructured	ADJ
bam-5830	574	27	cores	core	NOUN
bam-5830	574	28	)	)	PUNCT
bam-5830	574	29	.	.	PUNCT
bam-5830	575	1	finally	finally	ADV
bam-5830	575	2	,	,	PUNCT
bam-5830	575	3	we	we	PRON
bam-5830	575	4	evaluated	evaluate	VERB
bam-5830	575	5	muscle	muscle	NOUN
bam-5830	575	6	function	function	NOUN
bam-5830	575	7	in	in	ADP
bam-5830	575	8	treated	treat	VERB
bam-5830	575	9	mice	mouse	NOUN
bam-5830	575	10	by	by	ADP
bam-5830	575	11	grip	grip	NOUN
bam-5830	575	12	strength	strength	NOUN
bam-5830	575	13	test	test	NOUN
bam-5830	575	14	:	:	PUNCT
bam-5830	575	15	nac	nac	PROPN
bam-5830	575	16	was	be	AUX
bam-5830	575	17	able	able	ADJ
bam-5830	575	18	to	to	PART
bam-5830	575	19	improve	improve	VERB
bam-5830	575	20	muscle	muscle	NOUN
bam-5830	575	21	strength	strength	NOUN
bam-5830	575	22	of	of	ADP
bam-5830	575	23	about	about	ADV
bam-5830	575	24	80	80	NUM
bam-5830	575	25	%	%	NOUN
bam-5830	575	26	.	.	PUNCT
bam-5830	576	1	this	this	DET
bam-5830	576	2	work	work	NOUN
bam-5830	576	3	provides	provide	VERB
bam-5830	576	4	the	the	DET
bam-5830	576	5	bases	basis	NOUN
bam-5830	576	6	for	for	ADP
bam-5830	576	7	clinical	clinical	ADJ
bam-5830	576	8	trial	trial	NOUN
bam-5830	576	9	as	as	SCONJ
bam-5830	576	10	it	it	PRON
bam-5830	576	11	demonstrate	demonstrate	VERB
bam-5830	576	12	that	that	SCONJ
bam-5830	576	13	nac	nac	PROPN
bam-5830	576	14	-	-	PUNCT
bam-5830	576	15	administration	administration	NOUN
bam-5830	576	16	prevents	prevent	VERB
bam-5830	576	17	mitochondrial	mitochondrial	ADJ
bam-5830	576	18	damage	damage	NOUN
bam-5830	576	19	,	,	PUNCT
bam-5830	576	20	development	development	NOUN
bam-5830	576	21	of	of	ADP
bam-5830	576	22	cores	core	NOUN
bam-5830	576	23	,	,	PUNCT
bam-5830	576	24	and	and	CCONJ
bam-5830	576	25	improves	improve	VERB
bam-5830	576	26	muscle	muscle	NOUN
bam-5830	576	27	function	function	NOUN
bam-5830	576	28	in	in	ADP
bam-5830	576	29	a	a	DET
bam-5830	576	30	mouse	mouse	NOUN
bam-5830	576	31	model	model	NOUN
bam-5830	576	32	of	of	ADP
bam-5830	576	33	ccd	ccd	PROPN
bam-5830	576	34	.	.	PUNCT
bam-5830	577	1	*	*	PUNCT
bam-5830	577	2	*	*	PUNCT
bam-5830	577	3	*	*	PUNCT
bam-5830	577	4	*	*	PUNCT
bam-5830	577	5	*	*	PUNCT
bam-5830	577	6	lethal	lethal	ADJ
bam-5830	577	7	exertional	exertional	ADJ
bam-5830	577	8	strokes	stroke	NOUN
bam-5830	577	9	in	in	ADP
bam-5830	577	10	ryr1y522s	ryr1y522s	NOUN
bam-5830	577	11	/	/	SYM
bam-5830	577	12	wt	wt	NOUN
bam-5830	577	13	and	and	CCONJ
bam-5830	577	14	casq1null	casq1null	NOUN
bam-5830	577	15	mice	mouse	NOUN
bam-5830	577	16	are	be	AUX
bam-5830	577	17	prevented	prevent	VERB
bam-5830	577	18	by	by	ADP
bam-5830	577	19	drugs	drug	NOUN
bam-5830	577	20	used	use	VERB
bam-5830	577	21	to	to	PART
bam-5830	577	22	treat	treat	VERB
bam-5830	577	23	malignant	malignant	ADJ
bam-5830	577	24	hyperthermia	hyperthermia	NOUN
bam-5830	577	25	in	in	ADP
bam-5830	577	26	humans	human	NOUN
bam-5830	577	27	a.	a.	NOUN
bam-5830	577	28	michelucci	michelucci	NOUN
bam-5830	577	29	1	1	NUM
bam-5830	577	30	,	,	PUNCT
bam-5830	577	31	c.	c.	PROPN
bam-5830	577	32	paolini	paolini	PROPN
bam-5830	577	33	1	1	NUM
bam-5830	577	34	,	,	PUNCT
bam-5830	577	35	s.	s.	PROPN
bam-5830	577	36	boncompagni	boncompagni	PROPN
bam-5830	577	37	1	1	NUM
bam-5830	577	38	,	,	PUNCT
bam-5830	577	39	m.	m.	NOUN
bam-5830	577	40	canato	canato	PROPN
bam-5830	577	41	3	3	NUM
bam-5830	577	42	,	,	PUNCT
bam-5830	577	43	s.	s.	PROPN
bam-5830	577	44	l.	l.	PROPN
bam-5830	577	45	hamilton	hamilton	PROPN
bam-5830	577	46	2	2	PROPN
bam-5830	577	47	,	,	PUNCT
bam-5830	577	48	c.	c.	PROPN
bam-5830	577	49	reggiani	reggiani	PROPN
bam-5830	577	50	3	3	NUM
bam-5830	577	51	,	,	PUNCT
bam-5830	577	52	f.	f.	PROPN
bam-5830	577	53	protasi	protasi	PROPN
bam-5830	577	54	1	1	NUM
bam-5830	577	55	1	1	NUM
bam-5830	577	56	cesi	cesi	NOUN
bam-5830	577	57	center	center	NOUN
bam-5830	577	58	for	for	ADP
bam-5830	577	59	research	research	NOUN
bam-5830	577	60	on	on	ADP
bam-5830	577	61	ageing	ageing	NOUN
bam-5830	577	62	&	&	CCONJ
bam-5830	577	63	dnics	dnic	NOUN
bam-5830	577	64	dept	dept	PROPN
bam-5830	577	65	.	.	PROPN
bam-5830	577	66	neuroscience	neuroscience	PROPN
bam-5830	577	67	,	,	PUNCT
bam-5830	577	68	imaging	imaging	NOUN
bam-5830	577	69	,	,	PUNCT
bam-5830	577	70	and	and	CCONJ
bam-5830	577	71	clinical	clinical	ADJ
bam-5830	577	72	sciences	science	NOUN
bam-5830	577	73	;	;	PUNCT
bam-5830	577	74	univ	univ	PROPN
bam-5830	577	75	.	.	PUNCT
bam-5830	578	1	g.	g.	PROPN
bam-5830	578	2	d’annunzio	d’annunzio	PROPN
bam-5830	578	3	,	,	PUNCT
bam-5830	578	4	chieti	chieti	PROPN
bam-5830	578	5	,	,	PUNCT
bam-5830	578	6	italy	italy	PROPN
bam-5830	578	7	.	.	PROPN
bam-5830	579	1	2	2	X
bam-5830	579	2	.	.	X
bam-5830	579	3	dept	dept	NOUN
bam-5830	579	4	.	.	PROPN
bam-5830	580	1	of	of	ADP
bam-5830	580	2	molecular	molecular	ADJ
bam-5830	580	3	physiology	physiology	NOUN
bam-5830	580	4	and	and	CCONJ
bam-5830	580	5	biophysics	biophysic	NOUN
bam-5830	580	6	;	;	PUNCT
bam-5830	580	7	baylor	baylor	PROPN
bam-5830	580	8	college	college	PROPN
bam-5830	580	9	of	of	ADP
bam-5830	580	10	medicine	medicine	NOUN
bam-5830	580	11	,	,	PUNCT
bam-5830	580	12	houston	houston	PROPN
bam-5830	580	13	,	,	PUNCT
bam-5830	580	14	tx	tx	PROPN
bam-5830	580	15	,	,	PUNCT
bam-5830	580	16	usa	usa	PROPN
bam-5830	580	17	.	.	PROPN
bam-5830	580	18	3	3	NUM
bam-5830	580	19	.	.	X
bam-5830	580	20	dept	dept	PROPN
bam-5830	580	21	.	.	PROPN
bam-5830	580	22	of	of	ADP
bam-5830	580	23	biomedical	biomedical	ADJ
bam-5830	580	24	sciences	science	NOUN
bam-5830	580	25	;	;	PUNCT
bam-5830	580	26	university	university	NOUN
bam-5830	580	27	of	of	ADP
bam-5830	580	28	padova	padova	PROPN
bam-5830	580	29	,	,	PUNCT
bam-5830	580	30	italy	italy	PROPN
bam-5830	580	31	e	e	PROPN
bam-5830	580	32	-	-	NOUN
bam-5830	580	33	mail	mail	NOUN
bam-5830	580	34	:	:	PUNCT
bam-5830	580	35	a.michelucci@unich.it	a.michelucci@unich.it	PUNCT
bam-5830	581	1	abstracts	abstract	NOUN
bam-5830	581	2	of	of	ADP
bam-5830	581	3	the	the	DET
bam-5830	581	4	xii	xii	PROPN
bam-5830	581	5	iim	iim	NOUN
bam-5830	581	6	myology	myology	NOUN
bam-5830	581	7	meeting	meeting	NOUN
bam-5830	581	8	october	october	PROPN
bam-5830	581	9	1–4	1–4	PROPN
bam-5830	581	10	,	,	PUNCT
bam-5830	581	11	2015	2015	NUM
bam-5830	581	12	eur	eur	PROPN
bam-5830	581	13	j	j	PROPN
bam-5830	581	14	transl	transl	PROPN
bam-5830	581	15	myol	myol	PROPN
bam-5830	581	16	basic	basic	ADJ
bam-5830	581	17	appl	appl	NOUN
bam-5830	581	18	myol	myol	NOUN
bam-5830	581	19	2016	2016	NUM
bam-5830	581	20	;	;	PUNCT
bam-5830	581	21	26	26	NUM
bam-5830	581	22	(	(	PUNCT
bam-5830	581	23	1):2	1):2	NUM
bam-5830	581	24	-	-	SYM
bam-5830	581	25	24	24	NUM
bam-5830	581	26	this	this	DET
bam-5830	581	27	article	article	NOUN
bam-5830	581	28	is	be	AUX
bam-5830	581	29	distributed	distribute	VERB
bam-5830	581	30	under	under	ADP
bam-5830	581	31	the	the	DET
bam-5830	581	32	terms	term	NOUN
bam-5830	581	33	of	of	ADP
bam-5830	581	34	the	the	DET
bam-5830	581	35	creative	creative	ADJ
bam-5830	581	36	commons	common	NOUN
bam-5830	581	37	attribution	attribution	NOUN
bam-5830	581	38	noncommercial	noncommercial	ADJ
bam-5830	581	39	license	license	NOUN
bam-5830	581	40	(	(	PUNCT
bam-5830	581	41	cc	cc	NOUN
bam-5830	581	42	by	by	ADP
bam-5830	581	43	-	-	PUNCT
bam-5830	581	44	nc	nc	PROPN
bam-5830	581	45	4.0	4.0	NUM
bam-5830	581	46	)	)	PUNCT
bam-5830	581	47	which	which	PRON
bam-5830	581	48	permits	permit	VERB
bam-5830	581	49	any	any	DET
bam-5830	581	50	noncommercial	noncommercial	ADJ
bam-5830	581	51	use	use	NOUN
bam-5830	581	52	,	,	PUNCT
bam-5830	581	53	distribution	distribution	NOUN
bam-5830	581	54	,	,	PUNCT
bam-5830	581	55	and	and	CCONJ
bam-5830	581	56	reproduction	reproduction	NOUN
bam-5830	581	57	in	in	ADP
bam-5830	581	58	any	any	DET
bam-5830	581	59	medium	medium	NOUN
bam-5830	581	60	,	,	PUNCT
bam-5830	581	61	provided	provide	VERB
bam-5830	581	62	the	the	DET
bam-5830	581	63	original	original	ADJ
bam-5830	581	64	author(s	author(s	NOUN
bam-5830	581	65	)	)	PUNCT
bam-5830	581	66	and	and	CCONJ
bam-5830	581	67	source	source	NOUN
bam-5830	581	68	are	be	AUX
bam-5830	581	69	credited	credit	VERB
bam-5830	581	70	.	.	PUNCT
bam-5830	582	1	18	18	NUM
bam-5830	582	2	in	in	ADP
bam-5830	582	3	humans	human	NOUN
bam-5830	582	4	,	,	PUNCT
bam-5830	582	5	lethal	lethal	ADJ
bam-5830	582	6	hyperthermic	hyperthermic	ADJ
bam-5830	582	7	episodes	episode	NOUN
bam-5830	582	8	can	can	AUX
bam-5830	582	9	be	be	AUX
bam-5830	582	10	trigger	trigger	NOUN
bam-5830	582	11	by	by	ADP
bam-5830	582	12	anesthetics	anesthetic	NOUN
bam-5830	582	13	(	(	PUNCT
bam-5830	582	14	a	a	DET
bam-5830	582	15	disorder	disorder	NOUN
bam-5830	582	16	known	know	VERB
bam-5830	582	17	as	as	ADP
bam-5830	582	18	malignant	malignant	ADJ
bam-5830	582	19	hyperthermia	hyperthermia	NOUN
bam-5830	582	20	,	,	PUNCT
bam-5830	582	21	susceptibility	susceptibility	NOUN
bam-5830	582	22	,	,	PUNCT
bam-5830	582	23	mhs	mhs	PROPN
bam-5830	582	24	)	)	PUNCT
bam-5830	582	25	and	and	CCONJ
bam-5830	582	26	by	by	ADP
bam-5830	582	27	high	high	ADJ
bam-5830	582	28	temperature	temperature	NOUN
bam-5830	582	29	and/or	and/or	CCONJ
bam-5830	582	30	strenuous	strenuous	ADJ
bam-5830	582	31	exercise	exercise	NOUN
bam-5830	582	32	(	(	PUNCT
bam-5830	582	33	crises	crisis	NOUN
bam-5830	582	34	identified	identify	VERB
bam-5830	582	35	as	as	ADP
bam-5830	582	36	environmental/	environmental/	NUM
bam-5830	582	37	exertional	exertional	ADJ
bam-5830	582	38	heat	heat	NOUN
bam-5830	582	39	strokes	stroke	NOUN
bam-5830	582	40	,	,	PUNCT
bam-5830	582	41	ehss	ehss	PROPN
bam-5830	582	42	)	)	PUNCT
bam-5830	582	43	.	.	PUNCT
bam-5830	583	1	the	the	DET
bam-5830	583	2	correlation	correlation	NOUN
bam-5830	583	3	between	between	ADP
bam-5830	583	4	mhs	mhs	PROPN
bam-5830	583	5	and	and	CCONJ
bam-5830	583	6	ehs	ehs	NOUN
bam-5830	583	7	is	be	AUX
bam-5830	583	8	strongly	strongly	ADV
bam-5830	583	9	supported	support	VERB
bam-5830	583	10	by	by	ADP
bam-5830	583	11	extensive	extensive	ADJ
bam-5830	583	12	work	work	NOUN
bam-5830	583	13	in	in	ADP
bam-5830	583	14	animal	animal	NOUN
bam-5830	583	15	models	model	NOUN
bam-5830	583	16	:	:	PUNCT
bam-5830	583	17	indeed	indeed	ADV
bam-5830	583	18	,	,	PUNCT
bam-5830	583	19	both	both	PRON
bam-5830	583	20	ryr1y522s	ryr1y522s	ADJ
bam-5830	583	21	/	/	SYM
bam-5830	583	22	wt	wt	NOUN
bam-5830	583	23	knock	knock	NOUN
bam-5830	583	24	-	-	PUNCT
bam-5830	583	25	in	in	NOUN
bam-5830	583	26	and	and	CCONJ
bam-5830	583	27	casq-1	casq-1	VERB
bam-5830	583	28	knockout	knockout	NOUN
bam-5830	583	29	mice	mice	NOUN
bam-5830	583	30	trigger	trigger	NOUN
bam-5830	583	31	similar	similar	ADJ
bam-5830	583	32	lethal	lethal	ADJ
bam-5830	583	33	crises	crisis	NOUN
bam-5830	583	34	when	when	SCONJ
bam-5830	583	35	exposed	expose	VERB
bam-5830	583	36	to	to	ADP
bam-5830	583	37	both	both	CCONJ
bam-5830	583	38	halothane	halothane	ADJ
bam-5830	583	39	and	and	CCONJ
bam-5830	583	40	heat	heat	NOUN
bam-5830	583	41	.	.	PUNCT
bam-5830	584	1	here	here	ADV
bam-5830	584	2	we	we	PRON
bam-5830	584	3	tested	test	VERB
bam-5830	584	4	the	the	DET
bam-5830	584	5	following	following	ADJ
bam-5830	584	6	hypotheses	hypothesis	NOUN
bam-5830	584	7	:	:	PUNCT
bam-5830	584	8	a	a	X
bam-5830	584	9	)	)	PUNCT
bam-5830	584	10	strenuous	strenuous	ADJ
bam-5830	584	11	exercise	exercise	NOUN
bam-5830	584	12	is	be	AUX
bam-5830	584	13	a	a	DET
bam-5830	584	14	stimulus	stimulus	NOUN
bam-5830	584	15	capable	capable	ADJ
bam-5830	584	16	to	to	AUX
bam-5830	584	17	trigger	trigger	VERB
bam-5830	584	18	ehs	ehs	NOUN
bam-5830	584	19	-	-	PUNCT
bam-5830	584	20	lethal	lethal	ADJ
bam-5830	584	21	episodes	episode	NOUN
bam-5830	584	22	;	;	PUNCT
bam-5830	584	23	b	b	X
bam-5830	584	24	)	)	PUNCT
bam-5830	584	25	mhs	mhs	PROPN
bam-5830	584	26	and	and	CCONJ
bam-5830	584	27	ehs	ehs	PROPN
bam-5830	584	28	share	share	PROPN
bam-5830	584	29	common	common	ADJ
bam-5830	584	30	molecular	molecular	ADJ
bam-5830	584	31	mechanisms	mechanism	NOUN
bam-5830	584	32	underlying	underlie	VERB
bam-5830	584	33	crises	crisis	NOUN
bam-5830	584	34	.	.	PUNCT
bam-5830	585	1	when	when	SCONJ
bam-5830	585	2	ryr1	ryr1	PROPN
bam-5830	585	3	y522s	y522s	PROPN
bam-5830	585	4	/	/	SYM
bam-5830	585	5	wt	wt	PROPN
bam-5830	585	6	and	and	CCONJ
bam-5830	585	7	casq1	casq1	NOUN
bam-5830	585	8	-	-	ADJ
bam-5830	585	9	null	null	ADJ
bam-5830	585	10	mice	mouse	NOUN
bam-5830	585	11	were	be	AUX
bam-5830	585	12	subjected	subject	VERB
bam-5830	585	13	to	to	ADP
bam-5830	585	14	an	an	DET
bam-5830	585	15	exertional	exertional	ADJ
bam-5830	585	16	-	-	PUNCT
bam-5830	585	17	stress	stress	NOUN
bam-5830	585	18	(	(	PUNCT
bam-5830	585	19	es	es	NOUN
bam-5830	585	20	)	)	PUNCT
bam-5830	585	21	protocol	protocol	NOUN
bam-5830	585	22	(	(	PUNCT
bam-5830	585	23	executed	execute	VERB
bam-5830	585	24	on	on	ADP
bam-5830	585	25	a	a	DET
bam-5830	585	26	treadmill	treadmill	NOUN
bam-5830	585	27	placed	place	VERB
bam-5830	585	28	in	in	ADP
bam-5830	585	29	an	an	DET
bam-5830	585	30	environmental	environmental	ADJ
bam-5830	585	31	chamber	chamber	NOUN
bam-5830	585	32	)	)	PUNCT
bam-5830	585	33	,	,	PUNCT
bam-5830	585	34	which	which	PRON
bam-5830	585	35	was	be	AUX
bam-5830	585	36	well	well	ADV
bam-5830	585	37	tolerated	tolerate	VERB
bam-5830	585	38	by	by	ADP
bam-5830	585	39	wt	wt	NOUN
bam-5830	585	40	animals	animal	NOUN
bam-5830	585	41	(	(	PUNCT
bam-5830	585	42	0	0	NUM
bam-5830	585	43	%	%	NOUN
bam-5830	585	44	of	of	ADP
bam-5830	585	45	deaths	death	NOUN
bam-5830	585	46	)	)	PUNCT
bam-5830	585	47	,	,	PUNCT
bam-5830	585	48	the	the	DET
bam-5830	585	49	mortality	mortality	NOUN
bam-5830	585	50	rate	rate	NOUN
bam-5830	585	51	was	be	AUX
bam-5830	585	52	dramatically	dramatically	ADV
bam-5830	585	53	increased	increase	VERB
bam-5830	585	54	(	(	PUNCT
bam-5830	585	55	80	80	NUM
bam-5830	585	56	%	%	NOUN
bam-5830	585	57	and	and	CCONJ
bam-5830	585	58	75	75	NUM
bam-5830	585	59	%	%	NOUN
bam-5830	585	60	,	,	PUNCT
bam-5830	585	61	respectively	respectively	ADV
bam-5830	585	62	)	)	PUNCT
bam-5830	585	63	,	,	PUNCT
bam-5830	585	64	with	with	ADP
bam-5830	585	65	a	a	DET
bam-5830	585	66	rise	rise	NOUN
bam-5830	585	67	in	in	ADP
bam-5830	585	68	core	core	ADJ
bam-5830	585	69	temperature	temperature	NOUN
bam-5830	585	70	(	(	PUNCT
bam-5830	585	71	hyperthermia	hyperthermia	NOUN
bam-5830	585	72	)	)	PUNCT
bam-5830	585	73	significantly	significantly	ADV
bam-5830	585	74	higher	high	ADJ
bam-5830	585	75	than	than	ADP
bam-5830	585	76	in	in	ADP
bam-5830	585	77	wt	wt	NOUN
bam-5830	585	78	at	at	ADP
bam-5830	585	79	the	the	DET
bam-5830	585	80	end	end	NOUN
bam-5830	585	81	of	of	ADP
bam-5830	585	82	the	the	DET
bam-5830	585	83	stimulus	stimulus	NOUN
bam-5830	585	84	.	.	PUNCT
bam-5830	586	1	during	during	ADP
bam-5830	586	2	exertional	exertional	ADJ
bam-5830	586	3	-	-	PUNCT
bam-5830	586	4	crises	crisis	NOUN
bam-5830	586	5	,	,	PUNCT
bam-5830	586	6	most	most	ADJ
bam-5830	586	7	fibers	fiber	NOUN
bam-5830	586	8	from	from	ADP
bam-5830	586	9	ryr1	ryr1	PROPN
bam-5830	586	10	y522s	y522s	PROPN
bam-5830	586	11	/	/	SYM
bam-5830	586	12	wt	wt	PROPN
bam-5830	586	13	and	and	CCONJ
bam-5830	586	14	casq1	casq1	NOUN
bam-5830	586	15	-	-	ADJ
bam-5830	586	16	null	null	ADJ
bam-5830	586	17	mice	mouse	NOUN
bam-5830	586	18	suffer	suffer	VERB
bam-5830	586	19	severe	severe	ADJ
bam-5830	586	20	structural	structural	ADJ
bam-5830	586	21	damage	damage	NOUN
bam-5830	586	22	(	(	PUNCT
bam-5830	586	23	~99	~99	X
bam-5830	586	24	%	%	NOUN
bam-5830	586	25	and	and	CCONJ
bam-5830	586	26	~64	~64	PRON
bam-5830	586	27	%	%	NOUN
bam-5830	586	28	of	of	ADP
bam-5830	586	29	fibers	fiber	NOUN
bam-5830	586	30	,	,	PUNCT
bam-5830	586	31	respectively	respectively	ADV
bam-5830	586	32	)	)	PUNCT
bam-5830	586	33	,	,	PUNCT
bam-5830	586	34	indication	indication	NOUN
bam-5830	586	35	of	of	ADP
bam-5830	586	36	rhabdomyolysis	rhabdomyolysis	NOUN
bam-5830	586	37	.	.	PUNCT
bam-5830	587	1	importantly	importantly	ADV
bam-5830	587	2	,	,	PUNCT
bam-5830	587	3	pre	pre	ADJ
bam-5830	587	4	-	-	NOUN
bam-5830	587	5	treatment	treatment	NOUN
bam-5830	587	6	of	of	ADP
bam-5830	587	7	animals	animal	NOUN
bam-5830	587	8	with	with	ADP
bam-5830	587	9	azumolene	azumolene	NOUN
bam-5830	587	10	(	(	PUNCT
bam-5830	587	11	a	a	DET
bam-5830	587	12	more	more	ADV
bam-5830	587	13	water	water	NOUN
bam-5830	587	14	soluble	soluble	ADJ
bam-5830	587	15	dantrolene	dantrolene	ADJ
bam-5830	587	16	analog	analog	NOUN
bam-5830	587	17	,	,	PUNCT
bam-5830	587	18	the	the	DET
bam-5830	587	19	only	only	ADJ
bam-5830	587	20	drug	drug	NOUN
bam-5830	587	21	approved	approve	VERB
bam-5830	587	22	for	for	ADP
bam-5830	587	23	treatment	treatment	NOUN
bam-5830	587	24	of	of	ADP
bam-5830	587	25	mh	mh	PROPN
bam-5830	587	26	crises	crisis	NOUN
bam-5830	587	27	in	in	ADP
bam-5830	587	28	humans	human	NOUN
bam-5830	587	29	)	)	PUNCT
bam-5830	587	30	almost	almost	ADV
bam-5830	587	31	completely	completely	ADV
bam-5830	587	32	abolished	abolish	VERB
bam-5830	587	33	mortality	mortality	NOUN
bam-5830	587	34	rate	rate	NOUN
bam-5830	587	35	in	in	ADP
bam-5830	587	36	ryr1	ryr1	PROPN
bam-5830	587	37	y522s	y522s	PROPN
bam-5830	587	38	/	/	SYM
bam-5830	587	39	wt	wt	PROPN
bam-5830	587	40	and	and	CCONJ
bam-5830	587	41	casq1	casq1	NOUN
bam-5830	587	42	-	-	PUNCT
bam-5830	587	43	null	null	ADJ
bam-5830	587	44	animals	animal	NOUN
bam-5830	587	45	,	,	PUNCT
bam-5830	587	46	by	by	ADP
bam-5830	587	47	reducing	reduce	VERB
bam-5830	587	48	hyperthermia	hyperthermia	NOUN
bam-5830	587	49	,	,	PUNCT
bam-5830	587	50	rhabdomyolysis	rhabdomyolysis	NOUN
bam-5830	587	51	,	,	PUNCT
bam-5830	587	52	and	and	CCONJ
bam-5830	587	53	ca2+leak	ca2+leak	NOUN
bam-5830	587	54	from	from	ADP
bam-5830	587	55	the	the	DET
bam-5830	587	56	sr	sr	PROPN
bam-5830	587	57	.	.	PUNCT
bam-5830	588	1	all	all	DET
bam-5830	588	2	these	these	DET
bam-5830	588	3	results	result	NOUN
bam-5830	588	4	strongly	strongly	ADV
bam-5830	588	5	suggest	suggest	VERB
bam-5830	588	6	that	that	SCONJ
bam-5830	588	7	ehs	ehs	PROPN
bam-5830	588	8	share	share	VERB
bam-5830	588	9	common	common	ADJ
bam-5830	588	10	molecular	molecular	ADJ
bam-5830	588	11	mechanisms	mechanism	NOUN
bam-5830	588	12	with	with	ADP
bam-5830	588	13	anesthetic	anesthetic	NOUN
bam-5830	588	14	-	-	PUNCT
bam-5830	588	15	induced	induce	VERB
bam-5830	588	16	mh	mh	PROPN
bam-5830	588	17	episodes	episode	NOUN
bam-5830	588	18	and	and	CCONJ
bam-5830	588	19	that	that	SCONJ
bam-5830	588	20	drugs	drug	NOUN
bam-5830	588	21	used	use	VERB
bam-5830	588	22	to	to	PART
bam-5830	588	23	treat	treat	VERB
bam-5830	588	24	classic	classic	ADJ
bam-5830	588	25	mh	mh	PROPN
bam-5830	588	26	should	should	AUX
bam-5830	588	27	be	be	AUX
bam-5830	588	28	considered	consider	VERB
bam-5830	588	29	for	for	ADP
bam-5830	588	30	treatment	treatment	NOUN
bam-5830	588	31	of	of	ADP
bam-5830	588	32	ehs	ehs	NOUN
bam-5830	588	33	.	.	PUNCT
bam-5830	589	1	*	*	PUNCT
bam-5830	589	2	*	*	PUNCT
bam-5830	589	3	*	*	PUNCT
bam-5830	589	4	*	*	PUNCT
bam-5830	589	5	*	*	PUNCT
bam-5830	589	6	mdx	mdx	PROPN
bam-5830	589	7	/	/	SYM
bam-5830	589	8	ager–/	ager–/	PROPN
bam-5830	589	9	–	–	PUNCT
bam-5830	589	10	mice	mouse	NOUN
bam-5830	589	11	show	show	VERB
bam-5830	589	12	reduced	reduce	VERB
bam-5830	589	13	muscle	muscle	NOUN
bam-5830	589	14	necrosis	necrosis	NOUN
bam-5830	589	15	and	and	CCONJ
bam-5830	589	16	inflammation	inflammation	NOUN
bam-5830	589	17	compared	compare	VERB
bam-5830	589	18	with	with	ADP
bam-5830	589	19	mdx	mdx	NOUN
bam-5830	589	20	mice	mice	PROPN
bam-5830	589	21	l.	l.	PROPN
bam-5830	589	22	salvadori	salvadori	PROPN
bam-5830	589	23	*	*	PROPN
bam-5830	589	24	1	1	NUM
bam-5830	589	25	,	,	PUNCT
bam-5830	589	26	r.	r.	PROPN
bam-5830	589	27	sagheddu	sagheddu	PROPN
bam-5830	589	28	*	*	SYM
bam-5830	589	29	1,2	1,2	NUM
bam-5830	589	30	,	,	PUNCT
bam-5830	589	31	s.	s.	PROPN
bam-5830	589	32	chiappalupi	chiappalupi	PROPN
bam-5830	590	1	*	*	PROPN
bam-5830	590	2	1	1	NUM
bam-5830	590	3	,	,	PUNCT
bam-5830	590	4	r.	r.	PROPN
bam-5830	590	5	donato	donato	PROPN
bam-5830	590	6	1	1	NUM
bam-5830	590	7	,	,	PUNCT
bam-5830	590	8	g.	g.	PROPN
bam-5830	590	9	sorci	sorci	VERB
bam-5830	590	10	1	1	NUM
bam-5830	590	11	*	*	NOUN
bam-5830	590	12	these	these	DET
bam-5830	590	13	authors	author	NOUN
bam-5830	590	14	contributed	contribute	VERB
bam-5830	590	15	equally	equally	ADV
bam-5830	590	16	to	to	ADP
bam-5830	590	17	this	this	DET
bam-5830	590	18	work	work	NOUN
bam-5830	590	19	.	.	PUNCT
bam-5830	591	1	1	1	X
bam-5830	591	2	.	.	X
bam-5830	591	3	department	department	NOUN
bam-5830	591	4	of	of	ADP
bam-5830	591	5	experimental	experimental	ADJ
bam-5830	591	6	medicine	medicine	NOUN
bam-5830	591	7	,	,	PUNCT
bam-5830	591	8	university	university	PROPN
bam-5830	591	9	of	of	ADP
bam-5830	591	10	perugia	perugia	PROPN
bam-5830	591	11	,	,	PUNCT
bam-5830	591	12	perugia	perugia	PROPN
bam-5830	591	13	,	,	PUNCT
bam-5830	591	14	italy	italy	PROPN
bam-5830	591	15	;	;	PUNCT
bam-5830	591	16	2	2	X
bam-5830	591	17	.	.	X
bam-5830	591	18	department	department	NOUN
bam-5830	591	19	of	of	ADP
bam-5830	591	20	neuroscience	neuroscience	NOUN
bam-5830	591	21	,	,	PUNCT
bam-5830	591	22	imaging	imaging	NOUN
bam-5830	591	23	and	and	CCONJ
bam-5830	591	24	clinical	clinical	ADJ
bam-5830	591	25	sciences	science	NOUN
bam-5830	591	26	,	,	PUNCT
bam-5830	591	27	university	university	NOUN
bam-5830	591	28	g.	g.	PROPN
bam-5830	591	29	d'annunzio	d'annunzio	PROPN
bam-5830	591	30	,	,	PUNCT
bam-5830	591	31	chieti	chieti	PROPN
bam-5830	591	32	-	-	PUNCT
bam-5830	591	33	pescara	pescara	PROPN
bam-5830	591	34	,	,	PUNCT
bam-5830	591	35	italy	italy	PROPN
bam-5830	591	36	e	e	PROPN
bam-5830	591	37	-	-	NOUN
bam-5830	591	38	mail	mail	NOUN
bam-5830	591	39	:	:	PUNCT
bam-5830	591	40	laurasalvadori1988@gmail.com	laurasalvadori1988@gmail.com	PROPN
bam-5830	592	1	duchenne	duchenne	PROPN
bam-5830	592	2	muscular	muscular	ADJ
bam-5830	592	3	dystrophy	dystrophy	NOUN
bam-5830	592	4	(	(	PUNCT
bam-5830	592	5	dmd	dmd	NOUN
bam-5830	592	6	)	)	PUNCT
bam-5830	592	7	is	be	AUX
bam-5830	592	8	an	an	DET
bam-5830	592	9	x	x	ADV
bam-5830	592	10	-	-	ADJ
bam-5830	592	11	linked	link	VERB
bam-5830	592	12	neuromuscular	neuromuscular	ADJ
bam-5830	592	13	disorder	disorder	NOUN
bam-5830	592	14	characterized	characterize	VERB
bam-5830	592	15	by	by	ADP
bam-5830	592	16	progressive	progressive	ADJ
bam-5830	592	17	muscle	muscle	NOUN
bam-5830	592	18	degeneration	degeneration	NOUN
bam-5830	592	19	due	due	ADP
bam-5830	592	20	to	to	ADP
bam-5830	592	21	lack	lack	NOUN
bam-5830	592	22	of	of	ADP
bam-5830	592	23	dystrophin	dystrophin	NOUN
bam-5830	592	24	,	,	PUNCT
bam-5830	592	25	a	a	DET
bam-5830	592	26	protein	protein	NOUN
bam-5830	592	27	essential	essential	ADJ
bam-5830	592	28	for	for	ADP
bam-5830	592	29	the	the	DET
bam-5830	592	30	integrity	integrity	NOUN
bam-5830	592	31	of	of	ADP
bam-5830	592	32	sarcolemma	sarcolemma	PROPN
bam-5830	592	33	during	during	ADP
bam-5830	592	34	contraction	contraction	NOUN
bam-5830	592	35	.	.	PUNCT
bam-5830	593	1	in	in	ADP
bam-5830	593	2	dmd	dmd	NOUN
bam-5830	593	3	compensative	compensative	ADJ
bam-5830	593	4	degeneration	degeneration	NOUN
bam-5830	593	5	/	/	SYM
bam-5830	593	6	regeneration	regeneration	NOUN
bam-5830	593	7	cycles	cycle	NOUN
bam-5830	593	8	determine	determine	VERB
bam-5830	593	9	a	a	DET
bam-5830	593	10	condition	condition	NOUN
bam-5830	593	11	of	of	ADP
bam-5830	593	12	chronic	chronic	ADJ
bam-5830	593	13	inflammation	inflammation	NOUN
bam-5830	593	14	contributing	contribute	VERB
bam-5830	593	15	to	to	ADP
bam-5830	593	16	progressive	progressive	ADJ
bam-5830	593	17	muscle	muscle	NOUN
bam-5830	593	18	wasting	waste	VERB
bam-5830	593	19	.	.	PUNCT
bam-5830	594	1	rage	rage	NOUN
bam-5830	594	2	(	(	PUNCT
bam-5830	594	3	receptor	receptor	NOUN
bam-5830	594	4	for	for	ADP
bam-5830	594	5	advanced	advanced	ADJ
bam-5830	594	6	glycation	glycation	NOUN
bam-5830	594	7	end	end	NOUN
bam-5830	594	8	-	-	PUNCT
bam-5830	594	9	products	product	NOUN
bam-5830	594	10	)	)	PUNCT
bam-5830	594	11	is	be	AUX
bam-5830	594	12	a	a	DET
bam-5830	594	13	multiligand	multiligand	ADJ
bam-5830	594	14	receptor	receptor	NOUN
bam-5830	594	15	belonging	belong	VERB
bam-5830	594	16	to	to	ADP
bam-5830	594	17	the	the	DET
bam-5830	594	18	immunoglobulin	immunoglobulin	NOUN
bam-5830	594	19	superfamily	superfamily	ADV
bam-5830	594	20	involved	involve	VERB
bam-5830	594	21	in	in	ADP
bam-5830	594	22	physiological	physiological	ADJ
bam-5830	594	23	and	and	CCONJ
bam-5830	594	24	pathological	pathological	ADJ
bam-5830	594	25	processes	process	NOUN
bam-5830	594	26	including	include	VERB
bam-5830	594	27	inflammation	inflammation	NOUN
bam-5830	594	28	and	and	CCONJ
bam-5830	594	29	myogenesis	myogenesis	NOUN
bam-5830	594	30	[	[	X
bam-5830	594	31	1	1	NUM
bam-5830	594	32	]	]	PUNCT
bam-5830	594	33	.	.	PUNCT
bam-5830	595	1	rage	rage	NOUN
bam-5830	595	2	is	be	AUX
bam-5830	595	3	not	not	PART
bam-5830	595	4	expressed	express	VERB
bam-5830	595	5	in	in	ADP
bam-5830	595	6	adult	adult	NOUN
bam-5830	595	7	muscle	muscle	NOUN
bam-5830	595	8	tissue	tissue	NOUN
bam-5830	595	9	,	,	PUNCT
bam-5830	595	10	whereas	whereas	SCONJ
bam-5830	595	11	it	it	PRON
bam-5830	595	12	is	be	AUX
bam-5830	595	13	expressed	express	VERB
bam-5830	595	14	in	in	ADP
bam-5830	595	15	regenerating	regenerate	VERB
bam-5830	595	16	myofibers	myofiber	NOUN
bam-5830	595	17	during	during	ADP
bam-5830	595	18	muscle	muscle	NOUN
bam-5830	595	19	regeneration	regeneration	NOUN
bam-5830	596	1	[	[	X
bam-5830	596	2	2,3	2,3	NUM
bam-5830	596	3	]	]	PUNCT
bam-5830	596	4	,	,	PUNCT
bam-5830	596	5	in	in	ADP
bam-5830	596	6	dystrophic	dystrophic	ADJ
bam-5830	596	7	muscles	muscle	NOUN
bam-5830	596	8	and	and	CCONJ
bam-5830	596	9	activated	activate	VERB
bam-5830	596	10	immune	immune	ADJ
bam-5830	596	11	cells	cell	NOUN
bam-5830	596	12	.	.	PUNCT
bam-5830	597	1	to	to	PART
bam-5830	597	2	have	have	VERB
bam-5830	597	3	information	information	NOUN
bam-5830	597	4	about	about	ADP
bam-5830	597	5	the	the	DET
bam-5830	597	6	role	role	NOUN
bam-5830	597	7	of	of	ADP
bam-5830	597	8	rage	rage	NOUN
bam-5830	597	9	in	in	ADP
bam-5830	597	10	the	the	DET
bam-5830	597	11	pathophysiology	pathophysiology	NOUN
bam-5830	597	12	of	of	ADP
bam-5830	597	13	dmd	dmd	NOUN
bam-5830	597	14	we	we	PRON
bam-5830	597	15	generated	generate	VERB
bam-5830	597	16	a	a	DET
bam-5830	597	17	double	double	ADJ
bam-5830	597	18	mutant	mutant	NOUN
bam-5830	597	19	mdx	mdx	NOUN
bam-5830	597	20	/	/	SYM
bam-5830	597	21	ager–/	ager–/	PROPN
bam-5830	597	22	–	–	PUNCT
bam-5830	597	23	mouse	mouse	NOUN
bam-5830	597	24	lacking	lack	VERB
bam-5830	597	25	dystrophin	dystrophin	NOUN
bam-5830	597	26	and	and	CCONJ
bam-5830	597	27	rage	rage	NOUN
bam-5830	597	28	(	(	PUNCT
bam-5830	597	29	ager	ager	NOUN
bam-5830	597	30	)	)	PUNCT
bam-5830	597	31	.	.	PUNCT
bam-5830	598	1	we	we	PRON
bam-5830	598	2	analyzed	analyze	VERB
bam-5830	598	3	diaphragms	diaphragm	NOUN
bam-5830	598	4	and	and	CCONJ
bam-5830	598	5	hind	hind	ADJ
bam-5830	598	6	-	-	PUNCT
bam-5830	598	7	limb	limb	NOUN
bam-5830	598	8	muscles	muscle	NOUN
bam-5830	598	9	(	(	PUNCT
bam-5830	598	10	i.e.	i.e.	X
bam-5830	598	11	,	,	PUNCT
bam-5830	598	12	tibialis	tibiali	NOUN
bam-5830	598	13	anterior	anterior	ADJ
bam-5830	598	14	and	and	CCONJ
bam-5830	598	15	quadriceps	quadricep	NOUN
bam-5830	598	16	femoris	femoris	NOUN
bam-5830	598	17	)	)	PUNCT
bam-5830	598	18	of	of	ADP
bam-5830	598	19	mdx	mdx	PROPN
bam-5830	598	20	,	,	PUNCT
bam-5830	598	21	mdx	mdx	PROPN
bam-5830	598	22	/	/	SYM
bam-5830	598	23	ager–/	ager–/	PROPN
bam-5830	598	24	–	–	PUNCT
bam-5830	598	25	,	,	PUNCT
bam-5830	598	26	ager–/	ager–/	PROPN
bam-5830	598	27	–	–	PUNCT
bam-5830	598	28	and	and	CCONJ
bam-5830	598	29	wt	wt	NUM
bam-5830	598	30	mice	mouse	NOUN
bam-5830	598	31	at	at	ADP
bam-5830	598	32	different	different	ADJ
bam-5830	598	33	ages	age	NOUN
bam-5830	598	34	(	(	PUNCT
bam-5830	598	35	i.e.	i.e.	X
bam-5830	598	36	,	,	PUNCT
bam-5830	598	37	2	2	NUM
bam-5830	598	38	,	,	PUNCT
bam-5830	598	39	3	3	NUM
bam-5830	598	40	,	,	PUNCT
bam-5830	598	41	4	4	NUM
bam-5830	598	42	and	and	CCONJ
bam-5830	598	43	5	5	NUM
bam-5830	598	44	weeks	week	NOUN
bam-5830	598	45	,	,	PUNCT
bam-5830	598	46	and	and	CCONJ
bam-5830	598	47	3	3	NUM
bam-5830	598	48	and	and	CCONJ
bam-5830	598	49	6	6	NUM
bam-5830	598	50	months	month	NOUN
bam-5830	598	51	of	of	ADP
bam-5830	598	52	age	age	NOUN
bam-5830	598	53	)	)	PUNCT
bam-5830	598	54	.	.	PUNCT
bam-5830	599	1	we	we	PRON
bam-5830	599	2	found	find	VERB
bam-5830	599	3	that	that	SCONJ
bam-5830	599	4	although	although	SCONJ
bam-5830	599	5	the	the	DET
bam-5830	599	6	absence	absence	NOUN
bam-5830	599	7	of	of	ADP
bam-5830	599	8	rage	rage	NOUN
bam-5830	599	9	in	in	ADP
bam-5830	599	10	dystrophic	dystrophic	ADJ
bam-5830	599	11	mice	mouse	NOUN
bam-5830	599	12	did	do	AUX
bam-5830	599	13	not	not	PART
bam-5830	599	14	affect	affect	VERB
bam-5830	599	15	the	the	DET
bam-5830	599	16	onset	onset	NOUN
bam-5830	599	17	of	of	ADP
bam-5830	599	18	the	the	DET
bam-5830	599	19	pathology	pathology	NOUN
bam-5830	599	20	,	,	PUNCT
bam-5830	599	21	muscles	muscle	NOUN
bam-5830	599	22	of	of	ADP
bam-5830	599	23	5	5	NUM
bam-5830	599	24	weekand	weekand	NOUN
bam-5830	599	25	6	6	NUM
bam-5830	599	26	month	month	NOUN
bam-5830	599	27	-	-	PUNCT
bam-5830	599	28	old	old	ADJ
bam-5830	599	29	mdx	mdx	NOUN
bam-5830	599	30	/	/	SYM
bam-5830	599	31	ager–/	ager–/	PROPN
bam-5830	599	32	–	–	PUNCT
bam-5830	599	33	mice	mouse	NOUN
bam-5830	599	34	showed	show	VERB
bam-5830	599	35	significantly	significantly	ADV
bam-5830	599	36	reduced	reduce	VERB
bam-5830	599	37	numbers	number	NOUN
bam-5830	599	38	of	of	ADP
bam-5830	599	39	necrotic	necrotic	ADJ
bam-5830	599	40	myofibers	myofiber	NOUN
bam-5830	599	41	,	,	PUNCT
bam-5830	599	42	and	and	CCONJ
bam-5830	599	43	reduced	reduced	ADJ
bam-5830	599	44	areas	area	NOUN
bam-5830	599	45	of	of	ADP
bam-5830	599	46	immune	immune	ADJ
bam-5830	599	47	cell	cell	NOUN
bam-5830	599	48	infiltrate	infiltrate	NOUN
bam-5830	599	49	compared	compare	VERB
bam-5830	599	50	with	with	ADP
bam-5830	599	51	age	age	NOUN
bam-5830	599	52	-	-	PUNCT
bam-5830	599	53	matched	match	VERB
bam-5830	599	54	mdx	mdx	NOUN
bam-5830	599	55	mice	mouse	NOUN
bam-5830	599	56	.	.	PUNCT
bam-5830	600	1	also	also	ADV
bam-5830	600	2	,	,	PUNCT
bam-5830	600	3	muscles	muscle	NOUN
bam-5830	600	4	of	of	ADP
bam-5830	600	5	mdx	mdx	NOUN
bam-5830	600	6	/	/	SYM
bam-5830	600	7	ager–/–mice	ager–/–mice	PROPN
bam-5830	600	8	showed	show	VERB
bam-5830	600	9	strongly	strongly	ADV
bam-5830	600	10	reduced	reduce	VERB
bam-5830	600	11	expression	expression	NOUN
bam-5830	600	12	of	of	ADP
bam-5830	600	13	the	the	DET
bam-5830	600	14	marker	marker	NOUN
bam-5830	600	15	of	of	ADP
bam-5830	600	16	activated	activated	ADJ
bam-5830	600	17	macrophages	macrophage	NOUN
bam-5830	600	18	,	,	PUNCT
bam-5830	600	19	mac3	mac3	PROPN
bam-5830	600	20	,	,	PUNCT
bam-5830	600	21	compared	compare	VERB
bam-5830	600	22	with	with	ADP
bam-5830	600	23	mdx	mdx	NOUN
bam-5830	600	24	mice	mouse	NOUN
bam-5830	600	25	.	.	PUNCT
bam-5830	601	1	moreover	moreover	ADV
bam-5830	601	2	,	,	PUNCT
bam-5830	601	3	muscles	muscle	NOUN
bam-5830	601	4	of	of	ADP
bam-5830	601	5	mdx	mdx	PROPN
bam-5830	601	6	/	/	SYM
bam-5830	601	7	ager–/	ager–/	PROPN
bam-5830	601	8	–	–	PUNCT
bam-5830	601	9	mice	mouse	NOUN
bam-5830	601	10	exhibited	exhibit	VERB
bam-5830	601	11	significantly	significantly	ADV
bam-5830	601	12	reduced	reduce	VERB
bam-5830	601	13	pax7+ve	pax7+ve	ADJ
bam-5830	601	14	and	and	CCONJ
bam-5830	601	15	myogenin+ve	myogenin+ve	ADJ
bam-5830	601	16	cell	cell	NOUN
bam-5830	601	17	numbers	number	NOUN
bam-5830	601	18	,	,	PUNCT
bam-5830	601	19	pointing	point	VERB
bam-5830	601	20	to	to	ADP
bam-5830	601	21	a	a	DET
bam-5830	601	22	reduced	reduce	VERB
bam-5830	601	23	recruitment	recruitment	NOUN
bam-5830	601	24	of	of	ADP
bam-5830	601	25	muscle	muscle	NOUN
bam-5830	601	26	precursor	precursor	NOUN
bam-5830	601	27	cells	cell	NOUN
bam-5830	601	28	and	and	CCONJ
bam-5830	601	29	a	a	DET
bam-5830	601	30	more	more	ADV
bam-5830	601	31	efficient	efficient	ADJ
bam-5830	601	32	regeneration	regeneration	NOUN
bam-5830	601	33	in	in	ADP
bam-5830	601	34	dystrophic	dystrophic	ADJ
bam-5830	601	35	mice	mouse	NOUN
bam-5830	601	36	lacking	lack	VERB
bam-5830	601	37	rage	rage	NOUN
bam-5830	601	38	.	.	PUNCT
bam-5830	602	1	our	our	PRON
bam-5830	602	2	results	result	NOUN
bam-5830	602	3	suggest	suggest	VERB
bam-5830	602	4	that	that	SCONJ
bam-5830	602	5	rage	rage	NOUN
bam-5830	602	6	has	have	VERB
bam-5830	602	7	an	an	DET
bam-5830	602	8	important	important	ADJ
bam-5830	602	9	role	role	NOUN
bam-5830	602	10	in	in	ADP
bam-5830	602	11	sustaining	sustain	VERB
bam-5830	602	12	inflammatory	inflammatory	ADJ
bam-5830	602	13	and	and	CCONJ
bam-5830	602	14	degenerative	degenerative	ADJ
bam-5830	602	15	processes	process	NOUN
bam-5830	602	16	in	in	ADP
bam-5830	602	17	dystrophic	dystrophic	ADJ
bam-5830	602	18	muscles	muscle	NOUN
bam-5830	602	19	,	,	PUNCT
bam-5830	602	20	and	and	CCONJ
bam-5830	602	21	that	that	SCONJ
bam-5830	602	22	inhibition	inhibition	NOUN
bam-5830	602	23	of	of	ADP
bam-5830	602	24	rage	rage	NOUN
bam-5830	602	25	expression	expression	NOUN
bam-5830	602	26	/	/	SYM
bam-5830	602	27	activity	activity	NOUN
bam-5830	602	28	might	might	AUX
bam-5830	602	29	represent	represent	VERB
bam-5830	602	30	a	a	DET
bam-5830	602	31	potential	potential	ADJ
bam-5830	602	32	therapeutic	therapeutic	ADJ
bam-5830	602	33	approach	approach	NOUN
bam-5830	602	34	in	in	ADP
bam-5830	602	35	dmd	dmd	NOUN
bam-5830	602	36	patients	patient	NOUN
bam-5830	602	37	.	.	PUNCT
bam-5830	603	1	1	1	X
bam-5830	603	2	.	.	X
bam-5830	603	3	sorci	sorci	VERB
bam-5830	603	4	g	g	PROPN
bam-5830	603	5	,	,	PUNCT
bam-5830	603	6	et	et	PROPN
bam-5830	603	7	al	al	PROPN
bam-5830	603	8	.	.	PROPN
bam-5830	603	9	mol	mol	ADP
bam-5830	603	10	cell	cell	NOUN
bam-5830	603	11	biol	biol	NOUN
bam-5830	603	12	2004;24:4880	2004;24:4880	NUM
bam-5830	603	13	-	-	SYM
bam-5830	603	14	94	94	NUM
bam-5830	603	15	.	.	PUNCT
bam-5830	604	1	2	2	NUM
bam-5830	604	2	.	.	X
bam-5830	604	3	riuzzi	riuzzi	NOUN
bam-5830	604	4	f	f	PROPN
bam-5830	604	5	,	,	PUNCT
bam-5830	604	6	et	et	PROPN
bam-5830	604	7	al	al	PROPN
bam-5830	604	8	.	.	PUNCT
bam-5830	605	1	j	j	PROPN
bam-5830	605	2	cell	cell	NOUN
bam-5830	605	3	sci	sci	PROPN
bam-5830	605	4	2012;125:1440	2012;125:1440	PROPN
bam-5830	605	5	-	-	SYM
bam-5830	605	6	54	54	NUM
bam-5830	605	7	.	.	PUNCT
bam-5830	606	1	3	3	X
bam-5830	606	2	.	.	PROPN
bam-5830	606	3	haslbeck	haslbeck	PROPN
bam-5830	606	4	km	km	PROPN
bam-5830	606	5	,	,	PUNCT
bam-5830	606	6	et	et	PROPN
bam-5830	606	7	al	al	PROPN
bam-5830	606	8	.	.	PROPN
bam-5830	607	1	acta	acta	PROPN
bam-5830	607	2	neuropathol	neuropathol	PROPN
bam-5830	607	3	2005;110:247	2005;110:247	NUM
bam-5830	607	4	-	-	SYM
bam-5830	607	5	54	54	NUM
bam-5830	607	6	.	.	PUNCT
bam-5830	608	1	*	*	PUNCT
bam-5830	608	2	*	*	PUNCT
bam-5830	608	3	*	*	PUNCT
bam-5830	608	4	*	*	PUNCT
bam-5830	608	5	*	*	PUNCT
bam-5830	608	6	ageing	age	VERB
bam-5830	608	7	causes	cause	VERB
bam-5830	608	8	ultra	ultra	ADJ
bam-5830	608	9	-	-	ADJ
bam-5830	608	10	structural	structural	ADJ
bam-5830	608	11	modification	modification	NOUN
bam-5830	608	12	to	to	ADP
bam-5830	608	13	calcium	calcium	NOUN
bam-5830	608	14	release	release	NOUN
bam-5830	608	15	units	unit	NOUN
bam-5830	608	16	and	and	CCONJ
bam-5830	608	17	mitochondria	mitochondria	NOUN
bam-5830	608	18	in	in	ADP
bam-5830	608	19	cardiomyocytes	cardiomyocyte	NOUN
bam-5830	608	20	a.	a.	PROPN
bam-5830	608	21	di	di	PROPN
bam-5830	608	22	fonso	fonso	PROPN
bam-5830	608	23	*	*	PROPN
bam-5830	608	24	,	,	PUNCT
bam-5830	608	25	l.	l.	PROPN
bam-5830	608	26	d’onofrio	d’onofrio	PROPN
bam-5830	608	27	*	*	PROPN
bam-5830	608	28	,	,	PUNCT
bam-5830	608	29	a.	a.	NOUN
bam-5830	608	30	michelucci	michelucci	PROPN
bam-5830	608	31	,	,	PUNCT
bam-5830	608	32	f.	f.	PROPN
bam-5830	608	33	protasi	protasi	PROPN
bam-5830	608	34	,	,	PUNCT
bam-5830	608	35	s.	s.	PROPN
bam-5830	608	36	boncompagni	boncompagni	PROPN
bam-5830	608	37	*	*	VERB
bam-5830	608	38	these	these	DET
bam-5830	608	39	authors	author	NOUN
bam-5830	608	40	contributed	contribute	VERB
bam-5830	608	41	equally	equally	ADV
bam-5830	608	42	to	to	ADP
bam-5830	608	43	this	this	DET
bam-5830	608	44	work	work	NOUN
bam-5830	608	45	.	.	PUNCT
bam-5830	609	1	cesi	cesi	PROPN
bam-5830	609	2	center	center	PROPN
bam-5830	609	3	for	for	ADP
bam-5830	609	4	research	research	NOUN
bam-5830	609	5	on	on	ADP
bam-5830	609	6	ageing	ageing	NOUN
bam-5830	609	7	&	&	CCONJ
bam-5830	609	8	dept	dept	PROPN
bam-5830	609	9	.	.	PROPN
bam-5830	610	1	neuroscience	neuroscience	PROPN
bam-5830	610	2	,	,	PUNCT
bam-5830	610	3	imaging	imaging	NOUN
bam-5830	610	4	,	,	PUNCT
bam-5830	610	5	and	and	CCONJ
bam-5830	610	6	clinical	clinical	ADJ
bam-5830	610	7	sciences	science	NOUN
bam-5830	610	8	;	;	PUNCT
bam-5830	610	9	university	university	NOUN
bam-5830	610	10	g.	g.	PROPN
bam-5830	610	11	d’annunzio	d’annunzio	PROPN
bam-5830	610	12	of	of	ADP
bam-5830	610	13	chieti	chieti	PROPN
bam-5830	610	14	,	,	PUNCT
bam-5830	610	15	italy	italy	PROPN
bam-5830	610	16	e	e	PROPN
bam-5830	610	17	-	-	NOUN
bam-5830	610	18	mail	mail	NOUN
bam-5830	610	19	:	:	PUNCT
bam-5830	610	20	s.boncompagni@unich.it	s.boncompagni@unich.it	PUNCT
bam-5830	611	1	ageing	age	VERB
bam-5830	611	2	is	be	AUX
bam-5830	611	3	associated	associate	VERB
bam-5830	611	4	to	to	ADP
bam-5830	611	5	a	a	DET
bam-5830	611	6	dramatic	dramatic	ADJ
bam-5830	611	7	increase	increase	NOUN
bam-5830	611	8	in	in	ADP
bam-5830	611	9	the	the	DET
bam-5830	611	10	incidence	incidence	NOUN
bam-5830	611	11	of	of	ADP
bam-5830	611	12	heart	heart	NOUN
bam-5830	611	13	failure	failure	NOUN
bam-5830	611	14	,	,	PUNCT
bam-5830	611	15	even	even	ADV
bam-5830	611	16	if	if	SCONJ
bam-5830	611	17	the	the	DET
bam-5830	611	18	existence	existence	NOUN
bam-5830	611	19	of	of	ADP
bam-5830	611	20	a	a	DET
bam-5830	611	21	real	real	ADJ
bam-5830	611	22	age	age	NOUN
bam-5830	611	23	-	-	PUNCT
bam-5830	611	24	related	relate	VERB
bam-5830	611	25	cardiomyopathy	cardiomyopathy	ADJ
bam-5830	611	26	remains	remain	VERB
bam-5830	611	27	controversial	controversial	ADJ
bam-5830	611	28	.	.	PUNCT
bam-5830	612	1	as	as	SCONJ
bam-5830	612	2	effective	effective	ADJ
bam-5830	612	3	contraction	contraction	NOUN
bam-5830	612	4	and	and	CCONJ
bam-5830	612	5	relaxation	relaxation	NOUN
bam-5830	612	6	of	of	ADP
bam-5830	612	7	cardiomyocytes	cardiomyocyte	NOUN
bam-5830	612	8	also	also	ADV
bam-5830	612	9	depends	depend	VERB
bam-5830	612	10	on	on	ADP
bam-5830	612	11	ca2	ca2	PROPN
bam-5830	612	12	+	+	PROPN
bam-5830	612	13	supply	supply	NOUN
bam-5830	612	14	to	to	ADP
bam-5830	612	15	myofibrils	myofibril	NOUN
bam-5830	612	16	(	(	PUNCT
bam-5830	612	17	handled	handle	VERB
bam-5830	612	18	by	by	ADP
bam-5830	612	19	calcium	calcium	NOUN
bam-5830	612	20	release	release	NOUN
bam-5830	612	21	units	unit	NOUN
bam-5830	612	22	,	,	PUNCT
bam-5830	612	23	crus	crus	NOUN
bam-5830	612	24	)	)	PUNCT
bam-5830	612	25	and	and	CCONJ
bam-5830	612	26	on	on	ADP
bam-5830	612	27	efficient	efficient	ADJ
bam-5830	612	28	atp	atp	NOUN
bam-5830	612	29	production	production	NOUN
bam-5830	612	30	(	(	PUNCT
bam-5830	612	31	provided	provide	VERB
bam-5830	612	32	by	by	ADP
bam-5830	612	33	mitochondria	mitochondria	NOUN
bam-5830	612	34	)	)	PUNCT
bam-5830	612	35	,	,	PUNCT
bam-5830	612	36	in	in	ADP
bam-5830	612	37	this	this	DET
bam-5830	612	38	study	study	NOUN
bam-5830	612	39	we	we	PRON
bam-5830	612	40	performed	perform	VERB
bam-5830	612	41	a	a	DET
bam-5830	612	42	morphological	morphological	ADJ
bam-5830	612	43	study	study	NOUN
bam-5830	612	44	of	of	ADP
bam-5830	612	45	cardiac	cardiac	ADJ
bam-5830	612	46	cells	cell	NOUN
bam-5830	612	47	in	in	ADP
bam-5830	612	48	hearts	heart	NOUN
bam-5830	612	49	from	from	ADP
bam-5830	612	50	adult	adult	NOUN
bam-5830	612	51	and	and	CCONJ
bam-5830	612	52	old	old	ADJ
bam-5830	612	53	mice	mouse	NOUN
bam-5830	612	54	(	(	PUNCT
bam-5830	612	55	4	4	NUM
bam-5830	612	56	months	month	NOUN
bam-5830	612	57	vs.	vs.	X
bam-5830	612	58	≥	≥	NOUN
bam-5830	612	59	24	24	NUM
bam-5830	612	60	months	month	NOUN
bam-5830	612	61	of	of	ADP
bam-5830	612	62	age	age	NOUN
bam-5830	612	63	)	)	PUNCT
bam-5830	612	64	using	use	VERB
bam-5830	612	65	confocal	confocal	ADJ
bam-5830	612	66	and	and	CCONJ
bam-5830	612	67	electron	electron	NOUN
bam-5830	612	68	microscopy	microscopy	NOUN
bam-5830	612	69	.	.	PUNCT
bam-5830	613	1	the	the	DET
bam-5830	613	2	analysis	analysis	NOUN
bam-5830	613	3	of	of	ADP
bam-5830	613	4	crus	crus	NOUN
bam-5830	613	5	indicates	indicate	VERB
bam-5830	613	6	that	that	SCONJ
bam-5830	613	7	couplons	couplon	NOUN
bam-5830	613	8	become	become	VERB
bam-5830	613	9	shorter	short	ADJ
bam-5830	613	10	with	with	ADP
bam-5830	613	11	age	age	NOUN
bam-5830	613	12	and	and	CCONJ
bam-5830	613	13	that	that	SCONJ
bam-5830	613	14	the	the	DET
bam-5830	613	15	number	number	NOUN
bam-5830	613	16	of	of	ADP
bam-5830	613	17	crus/50	crus/50	NOUN
bam-5830	613	18	m2	m2	PROPN
bam-5830	613	19	is	be	AUX
bam-5830	613	20	decreased	decrease	VERB
bam-5830	613	21	of	of	ADP
bam-5830	613	22	about	about	ADV
bam-5830	613	23	24	24	NUM
bam-5830	613	24	%	%	NOUN
bam-5830	613	25	(	(	PUNCT
bam-5830	613	26	adults	adult	NOUN
bam-5830	613	27	:	:	PUNCT
bam-5830	613	28	5.1±0.32	5.1±0.32	NUM
bam-5830	613	29	;	;	PUNCT
bam-5830	613	30	old	old	ADJ
bam-5830	613	31	:	:	PUNCT
bam-5830	613	32	3.9±0.19	3.9±0.19	NUM
bam-5830	613	33	)	)	PUNCT
bam-5830	613	34	.	.	PUNCT
bam-5830	614	1	also	also	ADV
bam-5830	614	2	mitochondria	mitochondria	VERB
bam-5830	614	3	present	present	ADJ
bam-5830	614	4	structural	structural	ADJ
bam-5830	614	5	modifications	modification	NOUN
bam-5830	614	6	,	,	PUNCT
bam-5830	614	7	with	with	ADP
bam-5830	614	8	a	a	DET
bam-5830	614	9	significant	significant	ADJ
bam-5830	614	10	increase	increase	NOUN
bam-5830	614	11	in	in	ADP
bam-5830	614	12	the	the	DET
bam-5830	614	13	percentage	percentage	NOUN
bam-5830	614	14	of	of	ADP
bam-5830	614	15	organelles	organelle	NOUN
bam-5830	614	16	presenting	present	VERB
bam-5830	614	17	severe	severe	ADJ
bam-5830	614	18	alterations	alteration	NOUN
bam-5830	614	19	(	(	PUNCT
bam-5830	614	20	3.5	3.5	NUM
bam-5830	614	21	%	%	NOUN
bam-5830	614	22	vs.	vs.	ADP
bam-5830	614	23	16.5	16.5	NUM
bam-5830	614	24	%	%	NOUN
bam-5830	614	25	)	)	PUNCT
bam-5830	614	26	.	.	PUNCT
bam-5830	615	1	importantly	importantly	ADV
bam-5830	615	2	,	,	PUNCT
bam-5830	615	3	both	both	DET
bam-5830	615	4	crus	crus	NOUN
bam-5830	615	5	and	and	CCONJ
bam-5830	615	6	mitochondria	mitochondria	PROPN
bam-5830	615	7	undergo	undergo	VERB
bam-5830	615	8	a	a	DET
bam-5830	615	9	spatial	spatial	ADJ
bam-5830	615	10	re	re	NOUN
bam-5830	615	11	-	-	NOUN
bam-5830	615	12	organization	organization	NOUN
bam-5830	615	13	with	with	ADP
bam-5830	615	14	respect	respect	NOUN
bam-5830	615	15	to	to	ADP
bam-5830	615	16	sarcomeres	sarcomere	NOUN
bam-5830	615	17	/	/	SYM
bam-5830	615	18	myofibrils	myofibril	NOUN
bam-5830	615	19	:	:	PUNCT
bam-5830	615	20	crus	crus	NOUN
bam-5830	615	21	may	may	AUX
bam-5830	615	22	be	be	AUX
bam-5830	615	23	miss	miss	ADV
bam-5830	615	24	-	-	PUNCT
bam-5830	615	25	oriented	orient	VERB
bam-5830	615	26	(	(	PUNCT
bam-5830	615	27	longitudinal	longitudinal	ADJ
bam-5830	615	28	)	)	PUNCT
bam-5830	615	29	or	or	CCONJ
bam-5830	615	30	miss	miss	NOUN
bam-5830	615	31	-	-	PUNCT
bam-5830	615	32	placed	place	VERB
bam-5830	615	33	(	(	PUNCT
bam-5830	615	34	found	find	VERB
bam-5830	615	35	at	at	ADP
bam-5830	615	36	the	the	DET
bam-5830	615	37	a	a	DET
bam-5830	615	38	band	band	NOUN
bam-5830	615	39	instead	instead	ADV
bam-5830	615	40	of	of	ADP
bam-5830	615	41	being	be	AUX
bam-5830	615	42	correctly	correctly	ADV
bam-5830	615	43	placed	place	VERB
bam-5830	615	44	in	in	ADP
bam-5830	615	45	proximity	proximity	NOUN
bam-5830	615	46	of	of	ADP
bam-5830	615	47	z	z	NOUN
bam-5830	615	48	-	-	PUNCT
bam-5830	615	49	lines	line	NOUN
bam-5830	615	50	)	)	PUNCT
bam-5830	615	51	,	,	PUNCT
bam-5830	615	52	while	while	SCONJ
bam-5830	615	53	mitochondria	mitochondria	PROPN
bam-5830	615	54	are	be	AUX
bam-5830	615	55	often	often	ADV
bam-5830	615	56	grouped	group	VERB
bam-5830	615	57	in	in	ADP
bam-5830	615	58	an	an	DET
bam-5830	615	59	abnormal	abnormal	ADJ
bam-5830	615	60	fashion	fashion	NOUN
bam-5830	615	61	.	.	PUNCT
bam-5830	616	1	in	in	ADP
bam-5830	616	2	addition	addition	NOUN
bam-5830	616	3	,	,	PUNCT
bam-5830	616	4	wb	wb	PROPN
bam-5830	616	5	analysis	analysis	NOUN
bam-5830	616	6	shows	show	VERB
bam-5830	616	7	that	that	SCONJ
bam-5830	616	8	in	in	ADP
bam-5830	616	9	aged	aged	ADJ
bam-5830	616	10	mice	mouse	NOUN
bam-5830	616	11	,	,	PUNCT
bam-5830	616	12	there	there	PRON
bam-5830	616	13	is	be	VERB
bam-5830	616	14	a	a	DET
bam-5830	616	15	significant	significant	ADJ
bam-5830	616	16	reduced	reduce	VERB
bam-5830	616	17	expression	expression	NOUN
bam-5830	616	18	of	of	ADP
bam-5830	616	19	junctophilin-2	junctophilin-2	NUM
bam-5830	616	20	(	(	PUNCT
bam-5830	616	21	jp-2	jp-2	PROPN
bam-5830	616	22	)	)	PUNCT
bam-5830	616	23	,	,	PUNCT
bam-5830	616	24	a	a	DET
bam-5830	616	25	membrane	membrane	NOUN
bam-5830	616	26	protein	protein	NOUN
bam-5830	616	27	involved	involve	VERB
bam-5830	616	28	in	in	ADP
bam-5830	616	29	maintaining	maintain	VERB
bam-5830	616	30	stability	stability	NOUN
bam-5830	616	31	and	and	CCONJ
bam-5830	616	32	morphometry	morphometry	NOUN
bam-5830	616	33	of	of	ADP
bam-5830	616	34	dyads	dyad	NOUN
bam-5830	616	35	.	.	PUNCT
bam-5830	617	1	these	these	PRON
bam-5830	617	2	agerelated	agerelate	VERB
bam-5830	617	3	ultra	ultra	ADJ
bam-5830	617	4	-	-	ADJ
bam-5830	617	5	structural	structural	ADJ
bam-5830	617	6	changes	change	NOUN
bam-5830	617	7	may	may	AUX
bam-5830	617	8	underlie	underlie	VERB
bam-5830	617	9	an	an	DET
bam-5830	617	10	inefficient	inefficient	ADJ
bam-5830	617	11	supply	supply	NOUN
bam-5830	617	12	of	of	ADP
bam-5830	617	13	ca2	ca2	PROPN
bam-5830	617	14	+	+	PROPN
bam-5830	617	15	and	and	CCONJ
bam-5830	617	16	atp	atp	NOUN
bam-5830	617	17	to	to	ADP
bam-5830	617	18	contractile	contractile	NOUN
bam-5830	617	19	elements	element	NOUN
bam-5830	617	20	,	,	PUNCT
bam-5830	617	21	providing	provide	VERB
bam-5830	617	22	a	a	DET
bam-5830	617	23	possible	possible	ADJ
bam-5830	617	24	explanation	explanation	NOUN
bam-5830	617	25	for	for	ADP
bam-5830	617	26	heart	heart	NOUN
bam-5830	617	27	dysfunction	dysfunction	NOUN
bam-5830	617	28	associate	associate	NOUN
bam-5830	617	29	to	to	ADP
bam-5830	617	30	age	age	NOUN
bam-5830	617	31	.	.	PUNCT
bam-5830	618	1	*	*	PUNCT
bam-5830	618	2	*	*	PUNCT
bam-5830	618	3	*	*	PUNCT
bam-5830	618	4	*	*	PUNCT
bam-5830	618	5	*	*	VERB
bam-5830	618	6	abstracts	abstract	NOUN
bam-5830	618	7	of	of	ADP
bam-5830	618	8	the	the	DET
bam-5830	618	9	xii	xii	PROPN
bam-5830	618	10	iim	iim	NOUN
bam-5830	618	11	myology	myology	NOUN
bam-5830	618	12	meeting	meeting	NOUN
bam-5830	618	13	october	october	PROPN
bam-5830	618	14	1–4	1–4	PROPN
bam-5830	618	15	,	,	PUNCT
bam-5830	618	16	2015	2015	NUM
bam-5830	618	17	eur	eur	PROPN
bam-5830	618	18	j	j	PROPN
bam-5830	618	19	transl	transl	PROPN
bam-5830	618	20	myol	myol	PROPN
bam-5830	618	21	basic	basic	ADJ
bam-5830	618	22	appl	appl	NOUN
bam-5830	618	23	myol	myol	NOUN
bam-5830	618	24	2016	2016	NUM
bam-5830	618	25	;	;	PUNCT
bam-5830	618	26	26	26	NUM
bam-5830	618	27	(	(	PUNCT
bam-5830	618	28	1):2	1):2	NUM
bam-5830	618	29	-	-	SYM
bam-5830	618	30	24	24	NUM
bam-5830	618	31	this	this	DET
bam-5830	618	32	article	article	NOUN
bam-5830	618	33	is	be	AUX
bam-5830	618	34	distributed	distribute	VERB
bam-5830	618	35	under	under	ADP
bam-5830	618	36	the	the	DET
bam-5830	618	37	terms	term	NOUN
bam-5830	618	38	of	of	ADP
bam-5830	618	39	the	the	DET
bam-5830	618	40	creative	creative	ADJ
bam-5830	618	41	commons	common	NOUN
bam-5830	618	42	attribution	attribution	NOUN
bam-5830	618	43	noncommercial	noncommercial	ADJ
bam-5830	618	44	license	license	NOUN
bam-5830	618	45	(	(	PUNCT
bam-5830	618	46	cc	cc	NOUN
bam-5830	618	47	by	by	ADP
bam-5830	618	48	-	-	PUNCT
bam-5830	618	49	nc	nc	PROPN
bam-5830	618	50	4.0	4.0	NUM
bam-5830	618	51	)	)	PUNCT
bam-5830	618	52	which	which	PRON
bam-5830	618	53	permits	permit	VERB
bam-5830	618	54	any	any	DET
bam-5830	618	55	noncommercial	noncommercial	ADJ
bam-5830	618	56	use	use	NOUN
bam-5830	618	57	,	,	PUNCT
bam-5830	618	58	distribution	distribution	NOUN
bam-5830	618	59	,	,	PUNCT
bam-5830	618	60	and	and	CCONJ
bam-5830	618	61	reproduction	reproduction	NOUN
bam-5830	618	62	in	in	ADP
bam-5830	618	63	any	any	DET
bam-5830	618	64	medium	medium	NOUN
bam-5830	618	65	,	,	PUNCT
bam-5830	618	66	provided	provide	VERB
bam-5830	618	67	the	the	DET
bam-5830	618	68	original	original	ADJ
bam-5830	618	69	author(s	author(s	NOUN
bam-5830	618	70	)	)	PUNCT
bam-5830	618	71	and	and	CCONJ
bam-5830	618	72	source	source	NOUN
bam-5830	618	73	are	be	AUX
bam-5830	618	74	credited	credit	VERB
bam-5830	618	75	.	.	PUNCT
bam-5830	619	1	19	19	NUM
bam-5830	619	2	chemokines	chemokine	NOUN
bam-5830	619	3	in	in	ADP
bam-5830	619	4	dystrophic	dystrophic	ADJ
bam-5830	619	5	heart	heart	NOUN
bam-5830	619	6	and	and	CCONJ
bam-5830	619	7	implications	implication	NOUN
bam-5830	619	8	for	for	ADP
bam-5830	619	9	stem	stem	NOUN
bam-5830	619	10	cell	cell	NOUN
bam-5830	619	11	homing	homing	NOUN
bam-5830	619	12	/	/	SYM
bam-5830	619	13	therapy	therapy	NOUN
bam-5830	619	14	j.	j.	PROPN
bam-5830	619	15	camps	camps	PROPN
bam-5830	619	16	,	,	PUNCT
bam-5830	619	17	m.	m.	NOUN
bam-5830	619	18	quattrocelli	quattrocelli	PROPN
bam-5830	619	19	,	,	PUNCT
bam-5830	619	20	m.	m.	NOUN
bam-5830	619	21	sampaolesi	sampaolesi	PROPN
bam-5830	619	22	translational	translational	ADJ
bam-5830	619	23	cardiomyology	cardiomyology	NOUN
bam-5830	619	24	lab	lab	NOUN
bam-5830	619	25	,	,	PUNCT
bam-5830	619	26	dept	dept	NOUN
bam-5830	619	27	development	development	NOUN
bam-5830	619	28	&	&	CCONJ
bam-5830	619	29	regeneration	regeneration	PROPN
bam-5830	619	30	,	,	PUNCT
bam-5830	619	31	ku	ku	PROPN
bam-5830	619	32	leuven	leuven	PROPN
bam-5830	619	33	,	,	PUNCT
bam-5830	619	34	leuven	leuven	PROPN
bam-5830	619	35	,	,	PUNCT
bam-5830	619	36	belgium	belgium	NOUN
bam-5830	619	37	e	e	NOUN
bam-5830	619	38	-	-	NOUN
bam-5830	619	39	mail	mail	NOUN
bam-5830	619	40	:	:	PUNCT
bam-5830	619	41	jordi.camps@kuleuven.be	jordi.camps@kuleuven.be	ADJ
bam-5830	619	42	progressive	progressive	ADJ
bam-5830	619	43	muscle	muscle	NOUN
bam-5830	619	44	degeneration	degeneration	NOUN
bam-5830	619	45	followed	follow	VERB
bam-5830	619	46	by	by	ADP
bam-5830	619	47	dilated	dilate	VERB
bam-5830	619	48	cardiomyopathy	cardiomyopathy	ADJ
bam-5830	619	49	is	be	AUX
bam-5830	619	50	a	a	DET
bam-5830	619	51	hallmark	hallmark	NOUN
bam-5830	619	52	of	of	ADP
bam-5830	619	53	muscular	muscular	ADJ
bam-5830	619	54	dystrophy	dystrophy	NOUN
bam-5830	619	55	.	.	PUNCT
bam-5830	620	1	stem	stem	NOUN
bam-5830	620	2	cell	cell	NOUN
bam-5830	620	3	therapy	therapy	NOUN
bam-5830	620	4	is	be	AUX
bam-5830	620	5	suggested	suggest	VERB
bam-5830	620	6	to	to	PART
bam-5830	620	7	replace	replace	VERB
bam-5830	620	8	diseased	disease	VERB
bam-5830	620	9	by	by	ADP
bam-5830	620	10	healthy	healthy	ADJ
bam-5830	620	11	myofibers	myofiber	NOUN
bam-5830	620	12	,	,	PUNCT
bam-5830	620	13	although	although	SCONJ
bam-5830	620	14	so	so	ADV
bam-5830	620	15	far	far	ADV
bam-5830	620	16	we	we	PRON
bam-5830	620	17	are	be	AUX
bam-5830	620	18	faced	face	VERB
bam-5830	620	19	by	by	ADP
bam-5830	620	20	low	low	ADJ
bam-5830	620	21	efficiencies	efficiency	NOUN
bam-5830	620	22	of	of	ADP
bam-5830	620	23	migration	migration	NOUN
bam-5830	620	24	,	,	PUNCT
bam-5830	620	25	engraftment	engraftment	NOUN
bam-5830	620	26	and	and	CCONJ
bam-5830	620	27	differentiation	differentiation	NOUN
bam-5830	620	28	of	of	ADP
bam-5830	620	29	stem	stem	NOUN
bam-5830	620	30	cells	cell	NOUN
bam-5830	620	31	.	.	PUNCT
bam-5830	621	1	chemokines	chemokine	NOUN
bam-5830	621	2	are	be	AUX
bam-5830	621	3	signalling	signal	VERB
bam-5830	621	4	proteins	protein	NOUN
bam-5830	621	5	guiding	guiding	NOUN
bam-5830	621	6	cell	cell	NOUN
bam-5830	621	7	migration	migration	NOUN
bam-5830	621	8	and	and	CCONJ
bam-5830	621	9	have	have	AUX
bam-5830	621	10	been	be	AUX
bam-5830	621	11	shown	show	VERB
bam-5830	621	12	to	to	PART
bam-5830	621	13	tightly	tightly	ADV
bam-5830	621	14	regulate	regulate	VERB
bam-5830	621	15	cardiac	cardiac	ADJ
bam-5830	621	16	repair	repair	NOUN
bam-5830	621	17	.	.	PUNCT
bam-5830	622	1	we	we	PRON
bam-5830	622	2	sought	seek	VERB
bam-5830	622	3	to	to	PART
bam-5830	622	4	determine	determine	VERB
bam-5830	622	5	which	which	PRON
bam-5830	622	6	chemokines	chemokine	NOUN
bam-5830	622	7	are	be	AUX
bam-5830	622	8	expressed	express	VERB
bam-5830	622	9	in	in	ADP
bam-5830	622	10	a	a	DET
bam-5830	622	11	dystrophic	dystrophic	ADJ
bam-5830	622	12	heart	heart	NOUN
bam-5830	622	13	that	that	PRON
bam-5830	622	14	is	be	AUX
bam-5830	622	15	undergoing	undergo	VERB
bam-5830	622	16	cardiac	cardiac	ADJ
bam-5830	622	17	remodelling	remodelling	NOUN
bam-5830	622	18	.	.	PUNCT
bam-5830	623	1	therefor	therefor	ADP
bam-5830	623	2	we	we	PRON
bam-5830	623	3	analysed	analyse	VERB
bam-5830	623	4	chemokine	chemokine	ADJ
bam-5830	623	5	expression	expression	NOUN
bam-5830	623	6	of	of	ADP
bam-5830	623	7	sarcoglycanα	sarcoglycanα	NOUN
bam-5830	623	8	(	(	PUNCT
bam-5830	623	9	sgcα	sgcα	NOUN
bam-5830	623	10	)	)	PUNCT
bam-5830	623	11	null	null	ADJ
bam-5830	623	12	,	,	PUNCT
bam-5830	623	13	sarcoglycan	sarcoglycan	NOUN
bam-5830	623	14	-	-	PUNCT
bam-5830	623	15	β	β	X
bam-5830	623	16	(	(	PUNCT
bam-5830	623	17	sgcβ	sgcβ	NOUN
bam-5830	623	18	)	)	PUNCT
bam-5830	623	19	null	null	NOUN
bam-5830	623	20	and	and	CCONJ
bam-5830	623	21	immunodeficient	immunodeficient	NOUN
bam-5830	623	22	sgcβ	sgcβ	NOUN
bam-5830	623	23	-	-	PUNCT
bam-5830	623	24	null	null	NOUN
bam-5830	623	25	mice	mouse	NOUN
bam-5830	623	26	.	.	PUNCT
bam-5830	624	1	high	high	ADJ
bam-5830	624	2	expression	expression	NOUN
bam-5830	624	3	of	of	ADP
bam-5830	624	4	all	all	DET
bam-5830	624	5	three	three	NUM
bam-5830	624	6	monocyte	monocyte	ADJ
bam-5830	624	7	-	-	PUNCT
bam-5830	624	8	chemotactic	chemotactic	ADJ
bam-5830	624	9	proteins	protein	NOUN
bam-5830	624	10	was	be	AUX
bam-5830	624	11	observed	observe	VERB
bam-5830	624	12	,	,	PUNCT
bam-5830	624	13	especially	especially	ADV
bam-5830	624	14	ccl8	ccl8	NOUN
bam-5830	624	15	in	in	ADP
bam-5830	624	16	both	both	DET
bam-5830	624	17	sgcβ	sgcβ	NOUN
bam-5830	624	18	-	-	PUNCT
bam-5830	624	19	null	null	NOUN
bam-5830	624	20	models	model	NOUN
bam-5830	624	21	and	and	CCONJ
bam-5830	624	22	to	to	ADP
bam-5830	624	23	a	a	DET
bam-5830	624	24	greater	great	ADJ
bam-5830	624	25	extent	extent	NOUN
bam-5830	624	26	in	in	ADP
bam-5830	624	27	sgcα	sgcα	NOUN
bam-5830	624	28	-	-	PUNCT
bam-5830	624	29	null	null	NOUN
bam-5830	624	30	mice	mouse	NOUN
bam-5830	624	31	.	.	PUNCT
bam-5830	625	1	additionally	additionally	ADV
bam-5830	625	2	,	,	PUNCT
bam-5830	625	3	fractalkine	fractalkine	NOUN
bam-5830	625	4	(	(	PUNCT
bam-5830	625	5	cx3cl1	cx3cl1	NOUN
bam-5830	625	6	)	)	PUNCT
bam-5830	625	7	was	be	AUX
bam-5830	625	8	upregulated	upregulate	VERB
bam-5830	625	9	in	in	ADP
bam-5830	625	10	both	both	CCONJ
bam-5830	625	11	the	the	DET
bam-5830	625	12	immunocompetent	immunocompetent	ADJ
bam-5830	625	13	and	and	CCONJ
bam-5830	625	14	immunodeficient	immunodeficient	NOUN
bam-5830	625	15	sgcβ	sgcβ	NOUN
bam-5830	625	16	-	-	PUNCT
bam-5830	625	17	null	null	NOUN
bam-5830	625	18	mice	mouse	NOUN
bam-5830	625	19	.	.	PUNCT
bam-5830	626	1	in	in	ADP
bam-5830	626	2	addition	addition	NOUN
bam-5830	626	3	,	,	PUNCT
bam-5830	626	4	we	we	PRON
bam-5830	626	5	aim	aim	VERB
bam-5830	626	6	to	to	PART
bam-5830	626	7	evaluate	evaluate	VERB
bam-5830	626	8	the	the	DET
bam-5830	626	9	migration	migration	NOUN
bam-5830	626	10	potential	potential	NOUN
bam-5830	626	11	of	of	ADP
bam-5830	626	12	cardiovascular	cardiovascular	ADJ
bam-5830	626	13	progenitors	progenitor	NOUN
bam-5830	626	14	derived	derive	VERB
bam-5830	626	15	from	from	ADP
bam-5830	626	16	pluripotent	pluripotent	ADJ
bam-5830	626	17	stem	stem	NOUN
bam-5830	626	18	cells	cell	NOUN
bam-5830	626	19	in	in	ADP
bam-5830	626	20	vitro	vitro	NOUN
bam-5830	626	21	,	,	PUNCT
bam-5830	626	22	that	that	PRON
bam-5830	626	23	have	have	VERB
bam-5830	626	24	the	the	DET
bam-5830	626	25	potential	potential	NOUN
bam-5830	626	26	to	to	PART
bam-5830	626	27	differentiate	differentiate	VERB
bam-5830	626	28	with	with	ADP
bam-5830	626	29	high	high	ADJ
bam-5830	626	30	efficiency	efficiency	NOUN
bam-5830	626	31	towards	towards	ADP
bam-5830	626	32	cardiomyocytes	cardiomyocyte	NOUN
bam-5830	626	33	,	,	PUNCT
bam-5830	626	34	smooth	smooth	ADJ
bam-5830	626	35	muscle	muscle	NOUN
bam-5830	626	36	cells	cell	NOUN
bam-5830	626	37	and	and	CCONJ
bam-5830	626	38	endothelial	endothelial	ADJ
bam-5830	626	39	cells	cell	NOUN
bam-5830	626	40	in	in	ADP
bam-5830	626	41	vitro	vitro	VERB
bam-5830	626	42	.	.	PUNCT
bam-5830	627	1	we	we	PRON
bam-5830	627	2	plan	plan	VERB
bam-5830	627	3	to	to	PART
bam-5830	627	4	test	test	VERB
bam-5830	627	5	these	these	DET
bam-5830	627	6	cells	cell	NOUN
bam-5830	627	7	for	for	ADP
bam-5830	627	8	their	their	PRON
bam-5830	627	9	in	in	ADP
bam-5830	627	10	vivo	vivo	ADJ
bam-5830	627	11	differentiation	differentiation	NOUN
bam-5830	627	12	and	and	CCONJ
bam-5830	627	13	migration	migration	NOUN
bam-5830	627	14	capacity	capacity	NOUN
bam-5830	627	15	towards	towards	ADP
bam-5830	627	16	the	the	DET
bam-5830	627	17	previously	previously	ADV
bam-5830	627	18	mentioned	mention	VERB
bam-5830	627	19	chemokines	chemokine	NOUN
bam-5830	627	20	.	.	PUNCT
bam-5830	628	1	this	this	PRON
bam-5830	628	2	sheds	shed	VERB
bam-5830	628	3	perspective	perspective	NOUN
bam-5830	628	4	for	for	ADP
bam-5830	628	5	an	an	DET
bam-5830	628	6	approachable	approachable	ADJ
bam-5830	628	7	mechanism	mechanism	NOUN
bam-5830	628	8	,	,	PUNCT
bam-5830	628	9	which	which	PRON
bam-5830	628	10	could	could	AUX
bam-5830	628	11	potentially	potentially	ADV
bam-5830	628	12	improve	improve	VERB
bam-5830	628	13	stem	stem	NOUN
bam-5830	628	14	cell	cell	NOUN
bam-5830	628	15	homing	homing	NOUN
bam-5830	628	16	towards	towards	ADP
bam-5830	628	17	the	the	DET
bam-5830	628	18	dystrophic	dystrophic	ADJ
bam-5830	628	19	myocardium	myocardium	NOUN
bam-5830	628	20	.	.	PUNCT
bam-5830	629	1	*	*	PUNCT
bam-5830	629	2	*	*	PUNCT
bam-5830	629	3	*	*	PUNCT
bam-5830	629	4	*	*	PUNCT
bam-5830	629	5	*	*	PUNCT
bam-5830	629	6	long	long	ADJ
bam-5830	629	7	and	and	CCONJ
bam-5830	629	8	short	short	ADJ
bam-5830	629	9	-	-	PUNCT
bam-5830	629	10	term	term	NOUN
bam-5830	629	11	effects	effect	NOUN
bam-5830	629	12	of	of	ADP
bam-5830	629	13	plant	plant	NOUN
bam-5830	629	14	derived	derive	VERB
bam-5830	629	15	nutrients	nutrient	NOUN
bam-5830	629	16	on	on	ADP
bam-5830	629	17	dystrophic	dystrophic	ADJ
bam-5830	629	18	cardiomyopathy	cardiomyopathy	ADJ
bam-5830	629	19	f.	f.	PROPN
bam-5830	629	20	carotenuto	carotenuto	PROPN
bam-5830	629	21	1	1	NUM
bam-5830	629	22	,	,	PUNCT
bam-5830	629	23	m.	m.	NOUN
bam-5830	629	24	minieri	minieri	NOUN
bam-5830	629	25	2	2	NUM
bam-5830	629	26	,	,	PUNCT
bam-5830	629	27	p.	p.	NOUN
bam-5830	629	28	di	di	NOUN
bam-5830	629	29	nardo	nardo	PROPN
bam-5830	629	30	1	1	NUM
bam-5830	629	31	1	1	NUM
bam-5830	629	32	.	.	PUNCT
bam-5830	630	1	department	department	NOUN
bam-5830	630	2	of	of	ADP
bam-5830	630	3	clinical	clinical	ADJ
bam-5830	630	4	sciences	science	NOUN
bam-5830	630	5	and	and	CCONJ
bam-5830	630	6	translational	translational	ADJ
bam-5830	630	7	medicine	medicine	NOUN
bam-5830	630	8	,	,	PUNCT
bam-5830	630	9	university	university	NOUN
bam-5830	630	10	of	of	ADP
bam-5830	630	11	rome	rome	PROPN
bam-5830	630	12	tor	tor	PROPN
bam-5830	630	13	vergata	vergata	NOUN
bam-5830	630	14	;	;	PUNCT
bam-5830	630	15	2	2	X
bam-5830	630	16	.	.	X
bam-5830	630	17	department	department	NOUN
bam-5830	630	18	of	of	ADP
bam-5830	630	19	experimental	experimental	ADJ
bam-5830	630	20	medicine	medicine	NOUN
bam-5830	630	21	and	and	CCONJ
bam-5830	630	22	surgery	surgery	NOUN
bam-5830	630	23	,	,	PUNCT
bam-5830	630	24	university	university	NOUN
bam-5830	630	25	of	of	ADP
bam-5830	630	26	rome	rome	PROPN
bam-5830	630	27	tor	tor	PROPN
bam-5830	630	28	vergata	vergata	PROPN
bam-5830	630	29	,	,	PUNCT
bam-5830	630	30	rome	rome	PROPN
bam-5830	630	31	,	,	PUNCT
bam-5830	630	32	italy	italy	PROPN
bam-5830	630	33	e	e	PROPN
bam-5830	630	34	-	-	NOUN
bam-5830	630	35	mail	mail	NOUN
bam-5830	630	36	:	:	PUNCT
bam-5830	630	37	carotenuto@med.uniroma2.it	carotenuto@med.uniroma2.it	ADP
bam-5830	630	38	cardiac	cardiac	ADJ
bam-5830	630	39	dysfunction	dysfunction	NOUN
bam-5830	630	40	from	from	ADP
bam-5830	630	41	cardiomyopathy	cardiomyopathy	ADJ
bam-5830	630	42	is	be	AUX
bam-5830	630	43	a	a	DET
bam-5830	630	44	frequent	frequent	ADJ
bam-5830	630	45	manifestation	manifestation	NOUN
bam-5830	630	46	of	of	ADP
bam-5830	630	47	muscular	muscular	ADJ
bam-5830	630	48	dystrophy	dystrophy	NOUN
bam-5830	630	49	.	.	PUNCT
bam-5830	631	1	the	the	DET
bam-5830	631	2	primary	primary	ADJ
bam-5830	631	3	defect	defect	NOUN
bam-5830	631	4	common	common	ADJ
bam-5830	631	5	to	to	ADP
bam-5830	631	6	most	most	ADJ
bam-5830	631	7	dystrophies	dystrophy	NOUN
bam-5830	631	8	involves	involve	VERB
bam-5830	631	9	the	the	DET
bam-5830	631	10	disruption	disruption	NOUN
bam-5830	631	11	of	of	ADP
bam-5830	631	12	the	the	DET
bam-5830	631	13	dystrophin	dystrophin	NOUN
bam-5830	631	14	-	-	PUNCT
bam-5830	631	15	glycoprotein	glycoprotein	NOUN
bam-5830	631	16	complex	complex	NOUN
bam-5830	631	17	(	(	PUNCT
bam-5830	631	18	dgc	dgc	NOUN
bam-5830	631	19	)	)	PUNCT
bam-5830	631	20	with	with	ADP
bam-5830	631	21	subsequent	subsequent	ADJ
bam-5830	631	22	sarcolemma	sarcolemma	PROPN
bam-5830	631	23	instability	instability	NOUN
bam-5830	631	24	and	and	CCONJ
bam-5830	631	25	ca2	ca2	PROPN
bam-5830	631	26	+	+	PROPN
bam-5830	631	27	influx	influx	NOUN
bam-5830	631	28	,	,	PUNCT
bam-5830	631	29	inducing	induce	VERB
bam-5830	631	30	cellular	cellular	ADJ
bam-5830	631	31	necrosis	necrosis	NOUN
bam-5830	631	32	.	.	PUNCT
bam-5830	632	1	defective	defective	ADJ
bam-5830	632	2	ca2	ca2	PROPN
bam-5830	632	3	+	+	PROPN
bam-5830	632	4	uptake	uptake	NOUN
bam-5830	632	5	resulting	result	VERB
bam-5830	632	6	from	from	ADP
bam-5830	632	7	decreased	decrease	VERB
bam-5830	632	8	expression	expression	NOUN
bam-5830	632	9	and	and	CCONJ
bam-5830	632	10	reduced	reduced	ADJ
bam-5830	632	11	activity	activity	NOUN
bam-5830	632	12	of	of	ADP
bam-5830	632	13	calcium	calcium	NOUN
bam-5830	632	14	-	-	PUNCT
bam-5830	632	15	transporting	transport	VERB
bam-5830	632	16	atpase	atpase	PROPN
bam-5830	632	17	(	(	PUNCT
bam-5830	632	18	serca2a	serca2a	PROPN
bam-5830	632	19	)	)	PUNCT
bam-5830	633	1	and	and	CCONJ
bam-5830	633	2	,	,	PUNCT
bam-5830	633	3	recently	recently	ADV
bam-5830	633	4	,	,	PUNCT
bam-5830	633	5	serca2a	serca2a	PROPN
bam-5830	633	6	gene	gene	NOUN
bam-5830	633	7	therapy	therapy	NOUN
bam-5830	633	8	has	have	AUX
bam-5830	633	9	been	be	AUX
bam-5830	633	10	demonstrated	demonstrate	VERB
bam-5830	633	11	to	to	PART
bam-5830	633	12	mitigate	mitigate	VERB
bam-5830	633	13	dystrophic	dystrophic	ADJ
bam-5830	633	14	diseases	disease	NOUN
bam-5830	633	15	.	.	PUNCT
bam-5830	634	1	our	our	PRON
bam-5830	634	2	previous	previous	ADJ
bam-5830	634	3	studies	study	NOUN
bam-5830	634	4	have	have	AUX
bam-5830	634	5	demonstrated	demonstrate	VERB
bam-5830	634	6	that	that	SCONJ
bam-5830	634	7	the	the	DET
bam-5830	634	8	dystrophic	dystrophic	ADJ
bam-5830	634	9	phenotype	phenotype	NOUN
bam-5830	634	10	observed	observe	VERB
bam-5830	634	11	in	in	ADP
bam-5830	634	12	δ	δ	PROPN
bam-5830	634	13	-	-	ADJ
bam-5830	634	14	sarcoglycan	sarcoglycan	ADJ
bam-5830	634	15	–	–	PUNCT
bam-5830	634	16	null	null	ADJ
bam-5830	634	17	hamster	hamster	NOUN
bam-5830	634	18	is	be	AUX
bam-5830	634	19	dramatically	dramatically	ADV
bam-5830	634	20	improved	improve	VERB
bam-5830	634	21	by	by	ADP
bam-5830	634	22	a	a	DET
bam-5830	634	23	long	long	ADJ
bam-5830	634	24	-	-	PUNCT
bam-5830	634	25	term	term	NOUN
bam-5830	634	26	dietary	dietary	ADJ
bam-5830	634	27	supplementation	supplementation	NOUN
bam-5830	634	28	with	with	ADP
bam-5830	634	29	flaxseeds	flaxseed	NOUN
bam-5830	634	30	(	(	PUNCT
bam-5830	634	31	fs	fs	PROPN
bam-5830	634	32	)	)	PUNCT
bam-5830	634	33	(	(	PUNCT
bam-5830	634	34	rich	rich	ADJ
bam-5830	634	35	in	in	ADP
bam-5830	634	36	n3	n3	NOUN
bam-5830	634	37	-	-	PUNCT
bam-5830	634	38	pufas	pufas	NOUN
bam-5830	634	39	)	)	PUNCT
bam-5830	634	40	,	,	PUNCT
bam-5830	634	41	but	but	CCONJ
bam-5830	634	42	the	the	DET
bam-5830	634	43	molecular	molecular	ADJ
bam-5830	634	44	mechanisms	mechanism	NOUN
bam-5830	634	45	have	have	AUX
bam-5830	634	46	not	not	PART
bam-5830	634	47	yet	yet	ADV
bam-5830	634	48	been	be	AUX
bam-5830	634	49	fully	fully	ADV
bam-5830	634	50	understood	understand	VERB
bam-5830	634	51	.	.	PUNCT
bam-5830	635	1	the	the	DET
bam-5830	635	2	present	present	ADJ
bam-5830	635	3	study	study	NOUN
bam-5830	635	4	was	be	AUX
bam-5830	635	5	designed	design	VERB
bam-5830	635	6	to	to	PART
bam-5830	635	7	test	test	VERB
bam-5830	635	8	the	the	DET
bam-5830	635	9	hypothesis	hypothesis	NOUN
bam-5830	635	10	that	that	PRON
bam-5830	635	11	fs	f	VERB
bam-5830	635	12	enriched	enrich	VERB
bam-5830	635	13	diet	diet	NOUN
bam-5830	635	14	could	could	AUX
bam-5830	635	15	regulate	regulate	VERB
bam-5830	635	16	dgc	dgc	NOUN
bam-5830	635	17	and	and	CCONJ
bam-5830	635	18	serca2a	serca2a	PROPN
bam-5830	635	19	proteins	protein	NOUN
bam-5830	635	20	that	that	PRON
bam-5830	635	21	play	play	VERB
bam-5830	635	22	an	an	DET
bam-5830	635	23	important	important	ADJ
bam-5830	635	24	structural	structural	ADJ
bam-5830	635	25	and	and	CCONJ
bam-5830	635	26	functional	functional	ADJ
bam-5830	635	27	role	role	NOUN
bam-5830	635	28	in	in	ADP
bam-5830	635	29	cardiomyocytes	cardiomyocyte	NOUN
bam-5830	635	30	.	.	PUNCT
bam-5830	636	1	therefore	therefore	ADV
bam-5830	636	2	,	,	PUNCT
bam-5830	636	3	the	the	DET
bam-5830	636	4	levels	level	NOUN
bam-5830	636	5	of	of	ADP
bam-5830	636	6	these	these	DET
bam-5830	636	7	proteins	protein	NOUN
bam-5830	636	8	and	and	CCONJ
bam-5830	636	9	mrnas	mrna	NOUN
bam-5830	636	10	were	be	AUX
bam-5830	636	11	analyzed	analyze	VERB
bam-5830	636	12	in	in	ADP
bam-5830	636	13	heart	heart	NOUN
bam-5830	636	14	dystrophic	dystrophic	ADJ
bam-5830	636	15	hamsters	hamster	NOUN
bam-5830	636	16	fed	feed	VERB
bam-5830	636	17	with	with	ADP
bam-5830	636	18	fs	fs	ADP
bam-5830	636	19	diet	diet	NOUN
bam-5830	636	20	for	for	ADP
bam-5830	636	21	long	long	ADJ
bam-5830	636	22	(	(	PUNCT
bam-5830	636	23	five	five	NUM
bam-5830	636	24	months	month	NOUN
bam-5830	636	25	)	)	PUNCT
bam-5830	636	26	or	or	CCONJ
bam-5830	636	27	short	short	ADJ
bam-5830	636	28	time	time	NOUN
bam-5830	636	29	(	(	PUNCT
bam-5830	636	30	48	48	NUM
bam-5830	636	31	hours	hour	NOUN
bam-5830	636	32	)	)	PUNCT
bam-5830	636	33	.	.	PUNCT
bam-5830	637	1	results	result	NOUN
bam-5830	637	2	showed	show	VERB
bam-5830	637	3	that	that	SCONJ
bam-5830	637	4	distroglycan	distroglycan	ADJ
bam-5830	637	5	,	,	PUNCT
bam-5830	637	6	-	-	ADJ
bam-5830	637	7	,	,	PUNCT
bam-5830	637	8			NOUN
bam-5830	637	9	,	,	PUNCT
bam-5830	637	10	sarcoglycan	sarcoglycan	PROPN
bam-5830	637	11	and	and	CCONJ
bam-5830	637	12	serca2a	serca2a	PROPN
bam-5830	637	13	proteins	protein	NOUN
bam-5830	637	14	were	be	AUX
bam-5830	637	15	down	down	ADV
bam-5830	637	16	-	-	PUNCT
bam-5830	637	17	regulated	regulate	VERB
bam-5830	637	18	in	in	ADP
bam-5830	637	19	dystrophic	dystrophic	ADJ
bam-5830	637	20	hearts	heart	NOUN
bam-5830	637	21	and	and	CCONJ
bam-5830	637	22	fs	f	NOUN
bam-5830	637	23	-	-	PUNCT
bam-5830	637	24	diet	diet	NOUN
bam-5830	637	25	restored	restore	VERB
bam-5830	637	26	their	their	PRON
bam-5830	637	27	normal	normal	ADJ
bam-5830	637	28	expression	expression	NOUN
bam-5830	637	29	pattern	pattern	NOUN
bam-5830	637	30	.	.	PUNCT
bam-5830	638	1	the	the	DET
bam-5830	638	2	rt	rt	ADJ
bam-5830	638	3	-	-	PUNCT
bam-5830	638	4	pcr	pcr	NOUN
bam-5830	638	5	analysis	analysis	NOUN
bam-5830	638	6	showed	show	VERB
bam-5830	638	7	that	that	SCONJ
bam-5830	638	8	distroglycan	distroglycan	ADJ
bam-5830	638	9	,	,	PUNCT
bam-5830	638	10	-sarcoglycan	-sarcoglycan	PROPN
bam-5830	638	11	and	and	CCONJ
bam-5830	638	12	serca2a	serca2a	PROPN
bam-5830	638	13	were	be	AUX
bam-5830	638	14	upregulated	upregulate	VERB
bam-5830	638	15	at	at	ADP
bam-5830	638	16	the	the	DET
bam-5830	638	17	transcriptional	transcriptional	ADJ
bam-5830	638	18	level	level	NOUN
bam-5830	638	19	.	.	PUNCT
bam-5830	639	1	interestingly	interestingly	ADV
bam-5830	639	2	,	,	PUNCT
bam-5830	639	3	the	the	DET
bam-5830	639	4	mrnas	mrna	NOUN
bam-5830	639	5	increase	increase	NOUN
bam-5830	639	6	was	be	AUX
bam-5830	639	7	observed	observe	VERB
bam-5830	639	8	even	even	ADV
bam-5830	639	9	when	when	SCONJ
bam-5830	639	10	fs	f	NOUN
bam-5830	639	11	was	be	AUX
bam-5830	639	12	administered	administer	VERB
bam-5830	639	13	for	for	ADP
bam-5830	639	14	short	short	ADJ
bam-5830	639	15	periods	period	NOUN
bam-5830	639	16	suggesting	suggest	VERB
bam-5830	639	17	the	the	DET
bam-5830	639	18	involvement	involvement	NOUN
bam-5830	639	19	of	of	ADP
bam-5830	639	20	an	an	DET
bam-5830	639	21	epigenetic	epigenetic	ADJ
bam-5830	639	22	mechanism	mechanism	NOUN
bam-5830	639	23	.	.	PUNCT
bam-5830	640	1	therefore	therefore	ADV
bam-5830	640	2	,	,	PUNCT
bam-5830	640	3	it	it	PRON
bam-5830	640	4	seems	seem	VERB
bam-5830	640	5	plausible	plausible	ADJ
bam-5830	640	6	to	to	PART
bam-5830	640	7	consider	consider	VERB
bam-5830	640	8	the	the	DET
bam-5830	640	9	administration	administration	NOUN
bam-5830	640	10	of	of	ADP
bam-5830	640	11	plant	plant	NOUN
bam-5830	640	12	-	-	PUNCT
bam-5830	640	13	originated	originate	VERB
bam-5830	640	14	n-3	n-3	ADJ
bam-5830	640	15	pufas	pufas	NOUN
bam-5830	640	16	as	as	ADP
bam-5830	640	17	an	an	DET
bam-5830	640	18	adjuvant	adjuvant	ADJ
bam-5830	640	19	strategy	strategy	NOUN
bam-5830	640	20	for	for	ADP
bam-5830	640	21	attenuating	attenuate	VERB
bam-5830	640	22	sarcolemma	sarcolemma	ADJ
bam-5830	640	23	instability	instability	NOUN
bam-5830	640	24	and	and	CCONJ
bam-5830	640	25	defective	defective	ADJ
bam-5830	640	26	ca2	ca2	PROPN
bam-5830	640	27	+	+	PROPN
bam-5830	640	28	uptake	uptake	ADJ
bam-5830	640	29	that	that	PRON
bam-5830	640	30	represent	represent	VERB
bam-5830	640	31	major	major	ADJ
bam-5830	640	32	damages	damage	NOUN
bam-5830	640	33	associated	associate	VERB
bam-5830	640	34	with	with	ADP
bam-5830	640	35	dystrophic	dystrophic	ADJ
bam-5830	640	36	cardiomyopathies	cardiomyopathy	NOUN
bam-5830	640	37	.	.	PUNCT
bam-5830	641	1	*	*	PUNCT
bam-5830	641	2	*	*	PUNCT
bam-5830	641	3	*	*	PUNCT
bam-5830	641	4	*	*	PUNCT
bam-5830	641	5	*	*	PUNCT
bam-5830	641	6	*	*	PUNCT
bam-5830	641	7	*	*	PUNCT
bam-5830	641	8	*	*	PUNCT
bam-5830	641	9	*	*	PUNCT
bam-5830	641	10	*	*	PUNCT
bam-5830	641	11	*	*	PUNCT
bam-5830	641	12	*	*	PUNCT
bam-5830	641	13	*	*	PUNCT
bam-5830	641	14	*	*	PUNCT
bam-5830	641	15	*	*	PUNCT
bam-5830	641	16	session	session	NOUN
bam-5830	641	17	7	7	NUM
bam-5830	641	18	.	.	PUNCT
bam-5830	641	19	genetic	genetic	ADJ
bam-5830	641	20	and	and	CCONJ
bam-5830	641	21	epigenetic	epigenetic	ADJ
bam-5830	641	22	alterations	alteration	NOUN
bam-5830	641	23	in	in	ADP
bam-5830	641	24	muscle	muscle	NOUN
bam-5830	641	25	dystrophies	dystrophy	NOUN
bam-5830	641	26	and	and	CCONJ
bam-5830	641	27	myopathies	myopathy	NOUN
bam-5830	641	28	hdac4	hdac4	NOUN
bam-5830	641	29	modulates	modulate	VERB
bam-5830	641	30	the	the	DET
bam-5830	641	31	response	response	NOUN
bam-5830	641	32	to	to	PART
bam-5830	641	33	oxidative	oxidative	ADJ
bam-5830	641	34	stress	stress	NOUN
bam-5830	641	35	in	in	ADP
bam-5830	641	36	skeletal	skeletal	ADJ
bam-5830	641	37	muscle	muscle	NOUN
bam-5830	641	38	e.	e.	PROPN
bam-5830	641	39	pigna	pigna	PROPN
bam-5830	641	40	1	1	NUM
bam-5830	641	41	,	,	PUNCT
bam-5830	641	42	d.	d.	PROPN
bam-5830	641	43	coletti	coletti	PROPN
bam-5830	641	44	1,2	1,2	NUM
bam-5830	641	45	,	,	PUNCT
bam-5830	641	46	r.	r.	PROPN
bam-5830	641	47	mancinelli	mancinelli	PROPN
bam-5830	641	48	3	3	NUM
bam-5830	641	49	,	,	PUNCT
bam-5830	641	50	s.	s.	PROPN
bam-5830	641	51	adamo	adamo	PROPN
bam-5830	641	52	1	1	PROPN
bam-5830	641	53	,	,	PUNCT
bam-5830	641	54	v.	v.	CCONJ
bam-5830	641	55	moresi	moresi	ADJ
bam-5830	641	56	1	1	NUM
bam-5830	641	57	1	1	NUM
bam-5830	641	58	.	.	PUNCT
bam-5830	642	1	department	department	NOUN
bam-5830	642	2	of	of	ADP
bam-5830	642	3	anatomical	anatomical	ADJ
bam-5830	642	4	,	,	PUNCT
bam-5830	642	5	histological	histological	ADJ
bam-5830	642	6	,	,	PUNCT
bam-5830	642	7	forensic	forensic	ADJ
bam-5830	642	8	&	&	CCONJ
bam-5830	642	9	orthopaedic	orthopaedic	ADJ
bam-5830	642	10	sciences	sciences	PROPN
bam-5830	642	11	,	,	PUNCT
bam-5830	642	12	histology	histology	NOUN
bam-5830	642	13	&	&	CCONJ
bam-5830	642	14	medical	medical	ADJ
bam-5830	642	15	embryology	embryology	PROPN
bam-5830	642	16	section	section	NOUN
bam-5830	642	17	,	,	PUNCT
bam-5830	642	18	rome	rome	PROPN
bam-5830	642	19	,	,	PUNCT
bam-5830	642	20	sapienza	sapienza	PROPN
bam-5830	642	21	university	university	PROPN
bam-5830	642	22	of	of	ADP
bam-5830	642	23	rome	rome	PROPN
bam-5830	642	24	italy	italy	PROPN
bam-5830	642	25	;	;	PUNCT
bam-5830	642	26	2	2	X
bam-5830	642	27	.	.	X
bam-5830	642	28	department	department	NOUN
bam-5830	642	29	of	of	ADP
bam-5830	642	30	biological	biological	ADJ
bam-5830	642	31	adaptation	adaptation	NOUN
bam-5830	642	32	and	and	CCONJ
bam-5830	642	33	ageing	age	VERB
bam-5830	642	34	b2a	b2a	NOUN
bam-5830	642	35	(	(	PUNCT
bam-5830	642	36	cnrs	cnrs	NOUN
bam-5830	642	37	umr	umr	ADJ
bam-5830	642	38	8256	8256	NUM
bam-5830	642	39	inserm	inserm	NOUN
bam-5830	642	40	erl	erl	PROPN
bam-5830	642	41	u1164	u1164	PROPN
bam-5830	642	42	upmc	upmc	PROPN
bam-5830	642	43	p6	p6	PROPN
bam-5830	642	44	)	)	PUNCT
bam-5830	642	45	,	,	PUNCT
bam-5830	642	46	pierre	pierre	PROPN
bam-5830	642	47	et	et	PROPN
bam-5830	642	48	marie	marie	PROPN
bam-5830	642	49	curie	curie	PROPN
bam-5830	642	50	university	university	PROPN
bam-5830	642	51	,	,	PUNCT
bam-5830	642	52	paris	paris	PROPN
bam-5830	642	53	6	6	NUM
bam-5830	642	54	,	,	PUNCT
bam-5830	642	55	france	france	PROPN
bam-5830	642	56	;	;	PUNCT
bam-5830	642	57	3	3	X
bam-5830	642	58	.	.	X
bam-5830	642	59	department	department	NOUN
bam-5830	642	60	of	of	ADP
bam-5830	642	61	neuroscience	neuroscience	NOUN
bam-5830	642	62	imaging	imaging	NOUN
bam-5830	642	63	and	and	CCONJ
bam-5830	642	64	clinical	clinical	ADJ
bam-5830	642	65	sciences	science	NOUN
bam-5830	642	66	,	,	PUNCT
bam-5830	642	67	university	university	NOUN
bam-5830	642	68	g.	g.	PROPN
bam-5830	642	69	d	d	PROPN
bam-5830	642	70	annunzio	annunzio	VERB
bam-5830	642	71	chieti	chieti	PROPN
bam-5830	642	72	-	-	PUNCT
bam-5830	642	73	pescara	pescara	PROPN
bam-5830	642	74	,	,	PUNCT
bam-5830	642	75	chieti	chieti	PROPN
bam-5830	642	76	,	,	PUNCT
bam-5830	642	77	italy	italy	PROPN
bam-5830	642	78	e	e	PROPN
bam-5830	642	79	-	-	NOUN
bam-5830	642	80	mail	mail	NOUN
bam-5830	642	81	:	:	PUNCT
bam-5830	642	82	eva.pigna@uniroma1.it	eva.pigna@uniroma1.it	NOUN
bam-5830	642	83	oxidative	oxidative	ADJ
bam-5830	642	84	stress	stress	NOUN
bam-5830	642	85	(	(	PUNCT
bam-5830	642	86	os	os	NOUN
bam-5830	642	87	)	)	PUNCT
bam-5830	642	88	is	be	AUX
bam-5830	642	89	an	an	DET
bam-5830	642	90	imbalance	imbalance	NOUN
bam-5830	642	91	between	between	ADP
bam-5830	642	92	the	the	DET
bam-5830	642	93	production	production	NOUN
bam-5830	642	94	of	of	ADP
bam-5830	642	95	free	free	ADJ
bam-5830	642	96	radicals	radical	NOUN
bam-5830	642	97	,	,	PUNCT
bam-5830	642	98	in	in	ADP
bam-5830	642	99	particular	particular	ADJ
bam-5830	642	100	reactive	reactive	ADJ
bam-5830	642	101	oxygen	oxygen	NOUN
bam-5830	642	102	species	specie	NOUN
bam-5830	642	103	(	(	PUNCT
bam-5830	642	104	ros	ros	PROPN
bam-5830	642	105	)	)	PUNCT
bam-5830	642	106	,	,	PUNCT
bam-5830	642	107	and	and	CCONJ
bam-5830	642	108	the	the	DET
bam-5830	642	109	ability	ability	NOUN
bam-5830	642	110	of	of	ADP
bam-5830	642	111	the	the	DET
bam-5830	642	112	cells	cell	NOUN
bam-5830	642	113	to	to	PART
bam-5830	642	114	counteract	counteract	VERB
bam-5830	642	115	them	they	PRON
bam-5830	642	116	by	by	ADP
bam-5830	642	117	antioxidant	antioxidant	ADJ
bam-5830	642	118	responses	response	NOUN
bam-5830	642	119	.	.	PUNCT
bam-5830	643	1	ros	ros	PROPN
bam-5830	643	2	production	production	NOUN
bam-5830	643	3	in	in	ADP
bam-5830	643	4	skeletal	skeletal	ADJ
bam-5830	643	5	muscle	muscle	NOUN
bam-5830	643	6	occurs	occur	VERB
bam-5830	643	7	mainly	mainly	ADV
bam-5830	643	8	in	in	ADP
bam-5830	643	9	mitochondria	mitochondria	NOUN
bam-5830	643	10	,	,	PUNCT
bam-5830	643	11	both	both	PRON
bam-5830	643	12	following	follow	VERB
bam-5830	643	13	physiological	physiological	ADJ
bam-5830	643	14	stimuli	stimulus	NOUN
bam-5830	643	15	(	(	PUNCT
bam-5830	643	16	e.g.	e.g.	ADV
bam-5830	643	17	aging	aging	NOUN
bam-5830	643	18	,	,	PUNCT
bam-5830	643	19	physical	physical	ADJ
bam-5830	643	20	exercise	exercise	NOUN
bam-5830	643	21	,	,	PUNCT
bam-5830	643	22	or	or	CCONJ
bam-5830	643	23	at	at	ADP
bam-5830	643	24	birth	birth	NOUN
bam-5830	643	25	)	)	PUNCT
bam-5830	643	26	(	(	PUNCT
bam-5830	643	27	1	1	NUM
bam-5830	643	28	-	-	SYM
bam-5830	643	29	3	3	NUM
bam-5830	643	30	)	)	PUNCT
bam-5830	643	31	and	and	CCONJ
bam-5830	643	32	in	in	ADP
bam-5830	643	33	response	response	NOUN
bam-5830	643	34	to	to	ADP
bam-5830	643	35	pathological	pathological	ADJ
bam-5830	643	36	events	event	NOUN
bam-5830	643	37	,	,	PUNCT
bam-5830	643	38	such	such	ADJ
bam-5830	643	39	as	as	ADP
bam-5830	643	40	denervation	denervation	NOUN
bam-5830	643	41	(	(	PUNCT
bam-5830	643	42	4	4	NUM
bam-5830	643	43	)	)	PUNCT
bam-5830	643	44	.	.	PUNCT
bam-5830	644	1	in	in	ADP
bam-5830	644	2	all	all	DET
bam-5830	644	3	cases	case	NOUN
bam-5830	644	4	,	,	PUNCT
bam-5830	644	5	high	high	ADJ
bam-5830	644	6	levels	level	NOUN
bam-5830	644	7	of	of	ADP
bam-5830	644	8	ros	ros	PROPN
bam-5830	644	9	actively	actively	ADV
bam-5830	644	10	influence	influence	VERB
bam-5830	644	11	the	the	DET
bam-5830	644	12	maintenance	maintenance	NOUN
bam-5830	644	13	of	of	ADP
bam-5830	644	14	muscle	muscle	NOUN
bam-5830	644	15	homeostasis	homeostasis	NOUN
bam-5830	644	16	.	.	PUNCT
bam-5830	645	1	histone	histone	NOUN
bam-5830	645	2	deacetylase	deacetylase	VERB
bam-5830	645	3	4	4	NUM
bam-5830	645	4	(	(	PUNCT
bam-5830	645	5	hdac4	hdac4	PROPN
bam-5830	645	6	)	)	PUNCT
bam-5830	645	7	is	be	AUX
bam-5830	645	8	a	a	DET
bam-5830	645	9	member	member	NOUN
bam-5830	645	10	the	the	DET
bam-5830	645	11	class	class	NOUN
bam-5830	645	12	ii	ii	PROPN
bam-5830	645	13	of	of	ADP
bam-5830	645	14	the	the	DET
bam-5830	645	15	hdac	hdac	NOUN
bam-5830	645	16	superfamily	superfamily	NOUN
bam-5830	645	17	that	that	PRON
bam-5830	645	18	regulates	regulate	VERB
bam-5830	645	19	many	many	ADJ
bam-5830	645	20	cellular	cellular	ADJ
bam-5830	645	21	processes	process	NOUN
bam-5830	645	22	(	(	PUNCT
bam-5830	645	23	5	5	NUM
bam-5830	645	24	-	-	SYM
bam-5830	645	25	7	7	NUM
bam-5830	645	26	)	)	PUNCT
bam-5830	645	27	.	.	PUNCT
bam-5830	646	1	following	follow	VERB
bam-5830	646	2	denervation	denervation	NOUN
bam-5830	646	3	,	,	PUNCT
bam-5830	646	4	hdac4	hdac4	NOUN
bam-5830	646	5	is	be	AUX
bam-5830	646	6	upregulated	upregulate	VERB
bam-5830	646	7	in	in	ADP
bam-5830	646	8	skeletal	skeletal	ADJ
bam-5830	646	9	muscle	muscle	NOUN
bam-5830	646	10	:	:	PUNCT
bam-5830	646	11	it	it	PRON
bam-5830	646	12	induces	induce	VERB
bam-5830	646	13	muscle	muscle	NOUN
bam-5830	646	14	atrophy	atrophy	NOUN
bam-5830	646	15	and	and	CCONJ
bam-5830	646	16	represses	repress	VERB
bam-5830	646	17	reinnervation	reinnervation	NOUN
bam-5830	646	18	(	(	PUNCT
bam-5830	646	19	8	8	NUM
bam-5830	646	20	-	-	SYM
bam-5830	646	21	9	9	NUM
bam-5830	646	22	)	)	PUNCT
bam-5830	646	23	.	.	PUNCT
bam-5830	647	1	increased	increase	VERB
bam-5830	647	2	levels	level	NOUN
bam-5830	647	3	of	of	ADP
bam-5830	647	4	ros	ros	PROPN
bam-5830	647	5	cause	cause	VERB
bam-5830	647	6	hdac4	hdac4	NOUN
bam-5830	647	7	translocation	translocation	NOUN
bam-5830	647	8	from	from	ADP
bam-5830	647	9	the	the	DET
bam-5830	647	10	nucleus	nucleus	NOUN
bam-5830	647	11	to	to	ADP
bam-5830	647	12	the	the	DET
bam-5830	647	13	cytoplasm	cytoplasm	NOUN
bam-5830	647	14	,	,	PUNCT
bam-5830	647	15	thus	thus	ADV
bam-5830	647	16	inducing	induce	VERB
bam-5830	647	17	the	the	DET
bam-5830	647	18	release	release	NOUN
bam-5830	647	19	of	of	ADP
bam-5830	647	20	genes	gene	NOUN
bam-5830	647	21	transcriptionally	transcriptionally	ADV
bam-5830	647	22	repressed	repress	VERB
bam-5830	647	23	by	by	ADP
bam-5830	647	24	hdac4	hdac4	NOUN
bam-5830	647	25	(	(	PUNCT
bam-5830	647	26	10	10	NUM
bam-5830	647	27	)	)	PUNCT
bam-5830	647	28	.	.	PUNCT
bam-5830	648	1	however	however	ADV
bam-5830	648	2	,	,	PUNCT
bam-5830	648	3	hdac4	hdac4	NOUN
bam-5830	648	4	targets	target	NOUN
bam-5830	648	5	in	in	ADP
bam-5830	648	6	skeletal	skeletal	ADJ
bam-5830	648	7	muscle	muscle	NOUN
bam-5830	648	8	have	have	AUX
bam-5830	648	9	not	not	PART
bam-5830	648	10	been	be	AUX
bam-5830	648	11	discovered	discover	VERB
bam-5830	648	12	yet	yet	ADV
bam-5830	648	13	.	.	PUNCT
bam-5830	649	1	in	in	ADP
bam-5830	649	2	order	order	NOUN
bam-5830	649	3	to	to	PART
bam-5830	649	4	investigate	investigate	VERB
bam-5830	649	5	the	the	DET
bam-5830	649	6	role	role	NOUN
bam-5830	649	7	of	of	ADP
bam-5830	649	8	hdac4	hdac4	NOUN
bam-5830	649	9	in	in	ADP
bam-5830	649	10	response	response	NOUN
bam-5830	649	11	to	to	ADP
bam-5830	649	12	os	os	VERB
bam-5830	649	13	in	in	ADP
bam-5830	649	14	skeletal	skeletal	ADJ
bam-5830	649	15	muscle	muscle	NOUN
bam-5830	649	16	,	,	PUNCT
bam-5830	649	17	we	we	PRON
bam-5830	649	18	use	use	VERB
bam-5830	649	19	a	a	DET
bam-5830	649	20	mouse	mouse	NOUN
bam-5830	649	21	model	model	NOUN
bam-5830	649	22	with	with	ADP
bam-5830	649	23	the	the	DET
bam-5830	649	24	selective	selective	ADJ
bam-5830	649	25	deletion	deletion	NOUN
bam-5830	649	26	of	of	ADP
bam-5830	649	27	hdac4	hdac4	NOUN
bam-5830	649	28	in	in	ADP
bam-5830	649	29	myogenin	myogenin	ADJ
bam-5830	649	30	positive	positive	ADJ
bam-5830	649	31	cells	cell	NOUN
bam-5830	649	32	(	(	PUNCT
bam-5830	649	33	hdac4	hdac4	NOUN
bam-5830	649	34	mko	mko	PROPN
bam-5830	649	35	mice	mice	PROPN
bam-5830	649	36	)	)	PUNCT
bam-5830	649	37	.	.	PUNCT
bam-5830	650	1	hdac4	hdac4	PROPN
bam-5830	650	2	mko	mko	PROPN
bam-5830	650	3	mice	mouse	NOUN
bam-5830	650	4	are	be	AUX
bam-5830	650	5	viable	viable	ADJ
bam-5830	650	6	and	and	CCONJ
bam-5830	650	7	do	do	AUX
bam-5830	650	8	not	not	PART
bam-5830	650	9	show	show	VERB
bam-5830	650	10	gross	gross	ADJ
bam-5830	650	11	abnormalities	abnormality	NOUN
bam-5830	650	12	in	in	ADP
bam-5830	650	13	skeletal	skeletal	ADJ
bam-5830	650	14	muscle	muscle	NOUN
bam-5830	650	15	.	.	PUNCT
bam-5830	651	1	we	we	PRON
bam-5830	651	2	analyzed	analyze	VERB
bam-5830	651	3	mice	mouse	NOUN
bam-5830	651	4	in	in	ADP
bam-5830	651	5	two	two	NUM
bam-5830	651	6	different	different	ADJ
bam-5830	651	7	conditions	condition	NOUN
bam-5830	651	8	characterized	characterize	VERB
bam-5830	651	9	by	by	ADP
bam-5830	651	10	elevated	elevated	ADJ
bam-5830	651	11	os	os	NOUN
bam-5830	651	12	:	:	PUNCT
bam-5830	651	13	at	at	ADP
bam-5830	651	14	birth	birth	NOUN
bam-5830	651	15	and	and	CCONJ
bam-5830	651	16	in	in	ADP
bam-5830	651	17	adult	adult	NOUN
bam-5830	651	18	mice	mouse	NOUN
bam-5830	651	19	following	follow	VERB
bam-5830	651	20	denervation	denervation	NOUN
bam-5830	651	21	.	.	PUNCT
bam-5830	652	1	molecular	molecular	ADJ
bam-5830	652	2	responses	response	NOUN
bam-5830	652	3	to	to	PART
bam-5830	652	4	oxidative	oxidative	ADJ
bam-5830	652	5	stress	stress	NOUN
bam-5830	652	6	are	be	AUX
bam-5830	652	7	blunted	blunt	VERB
bam-5830	652	8	in	in	ADP
bam-5830	652	9	both	both	CCONJ
bam-5830	652	10	newborn	newborn	ADJ
bam-5830	652	11	and	and	CCONJ
bam-5830	652	12	adult	adult	NOUN
bam-5830	652	13	hdac4	hdac4	NOUN
bam-5830	652	14	mko	mko	NOUN
bam-5830	652	15	compared	compare	VERB
bam-5830	652	16	to	to	AUX
bam-5830	652	17	control	control	VERB
bam-5830	652	18	mice	mouse	NOUN
bam-5830	652	19	.	.	PUNCT
bam-5830	653	1	since	since	SCONJ
bam-5830	653	2	elevated	elevate	VERB
bam-5830	653	3	ros	ros	PROPN
bam-5830	653	4	contribute	contribute	VERB
bam-5830	653	5	to	to	ADP
bam-5830	653	6	abstracts	abstract	NOUN
bam-5830	653	7	of	of	ADP
bam-5830	653	8	the	the	DET
bam-5830	653	9	xii	xii	PROPN
bam-5830	653	10	iim	iim	NOUN
bam-5830	653	11	myology	myology	NOUN
bam-5830	653	12	meeting	meeting	NOUN
bam-5830	653	13	october	october	PROPN
bam-5830	653	14	1–4	1–4	PROPN
bam-5830	653	15	,	,	PUNCT
bam-5830	653	16	2015	2015	NUM
bam-5830	653	17	eur	eur	PROPN
bam-5830	653	18	j	j	PROPN
bam-5830	653	19	transl	transl	PROPN
bam-5830	653	20	myol	myol	PROPN
bam-5830	653	21	basic	basic	ADJ
bam-5830	653	22	appl	appl	NOUN
bam-5830	653	23	myol	myol	NOUN
bam-5830	653	24	2016	2016	NUM
bam-5830	653	25	;	;	PUNCT
bam-5830	653	26	26	26	NUM
bam-5830	653	27	(	(	PUNCT
bam-5830	653	28	1):2	1):2	NUM
bam-5830	653	29	-	-	SYM
bam-5830	653	30	24	24	NUM
bam-5830	653	31	this	this	DET
bam-5830	653	32	article	article	NOUN
bam-5830	653	33	is	be	AUX
bam-5830	653	34	distributed	distribute	VERB
bam-5830	653	35	under	under	ADP
bam-5830	653	36	the	the	DET
bam-5830	653	37	terms	term	NOUN
bam-5830	653	38	of	of	ADP
bam-5830	653	39	the	the	DET
bam-5830	653	40	creative	creative	ADJ
bam-5830	653	41	commons	common	NOUN
bam-5830	653	42	attribution	attribution	NOUN
bam-5830	653	43	noncommercial	noncommercial	ADJ
bam-5830	653	44	license	license	NOUN
bam-5830	653	45	(	(	PUNCT
bam-5830	653	46	cc	cc	NOUN
bam-5830	653	47	by	by	ADP
bam-5830	653	48	-	-	PUNCT
bam-5830	653	49	nc	nc	PROPN
bam-5830	653	50	4.0	4.0	NUM
bam-5830	653	51	)	)	PUNCT
bam-5830	653	52	which	which	PRON
bam-5830	653	53	permits	permit	VERB
bam-5830	653	54	any	any	DET
bam-5830	653	55	noncommercial	noncommercial	ADJ
bam-5830	653	56	use	use	NOUN
bam-5830	653	57	,	,	PUNCT
bam-5830	653	58	distribution	distribution	NOUN
bam-5830	653	59	,	,	PUNCT
bam-5830	653	60	and	and	CCONJ
bam-5830	653	61	reproduction	reproduction	NOUN
bam-5830	653	62	in	in	ADP
bam-5830	653	63	any	any	DET
bam-5830	653	64	medium	medium	NOUN
bam-5830	653	65	,	,	PUNCT
bam-5830	653	66	provided	provide	VERB
bam-5830	653	67	the	the	DET
bam-5830	653	68	original	original	ADJ
bam-5830	653	69	author(s	author(s	NOUN
bam-5830	653	70	)	)	PUNCT
bam-5830	653	71	and	and	CCONJ
bam-5830	653	72	source	source	NOUN
bam-5830	653	73	are	be	AUX
bam-5830	653	74	credited	credit	VERB
bam-5830	653	75	.	.	PUNCT
bam-5830	654	1	20	20	NUM
bam-5830	654	2	mitochondrial	mitochondrial	ADJ
bam-5830	654	3	damage	damage	NOUN
bam-5830	654	4	and	and	CCONJ
bam-5830	654	5	are	be	AUX
bam-5830	654	6	important	important	ADJ
bam-5830	654	7	in	in	ADP
bam-5830	654	8	redox	redox	NOUN
bam-5830	654	9	signaling	signal	VERB
bam-5830	654	10	from	from	ADP
bam-5830	654	11	the	the	DET
bam-5830	654	12	organelle	organelle	NOUN
bam-5830	654	13	to	to	ADP
bam-5830	654	14	the	the	DET
bam-5830	654	15	rest	rest	NOUN
bam-5830	654	16	of	of	ADP
bam-5830	654	17	the	the	DET
bam-5830	654	18	cell	cell	NOUN
bam-5830	654	19	,	,	PUNCT
bam-5830	654	20	we	we	PRON
bam-5830	654	21	analyzed	analyze	VERB
bam-5830	654	22	mitochondrial	mitochondrial	ADJ
bam-5830	654	23	ultrastructure	ultrastructure	NOUN
bam-5830	654	24	.	.	PUNCT
bam-5830	655	1	both	both	DET
bam-5830	655	2	newborn	newborn	ADJ
bam-5830	655	3	and	and	CCONJ
bam-5830	655	4	adult	adult	NOUN
bam-5830	655	5	hdac4	hdac4	NOUN
bam-5830	655	6	mko	mko	PROPN
bam-5830	655	7	muscles	muscle	NOUN
bam-5830	655	8	presented	present	VERB
bam-5830	655	9	damaged	damage	VERB
bam-5830	655	10	mitochondria	mitochondria	NOUN
bam-5830	655	11	,	,	PUNCT
bam-5830	655	12	altered	alter	VERB
bam-5830	655	13	mitochondrial	mitochondrial	ADJ
bam-5830	655	14	dynamics	dynamic	NOUN
bam-5830	655	15	and	and	CCONJ
bam-5830	655	16	defects	defect	NOUN
bam-5830	655	17	in	in	ADP
bam-5830	655	18	myofiber	myofiber	ADJ
bam-5830	655	19	organization	organization	NOUN
bam-5830	655	20	.	.	PUNCT
bam-5830	656	1	our	our	PRON
bam-5830	656	2	results	result	NOUN
bam-5830	656	3	indicate	indicate	VERB
bam-5830	656	4	that	that	DET
bam-5830	656	5	hdac4	hdac4	NOUN
bam-5830	656	6	is	be	AUX
bam-5830	656	7	important	important	ADJ
bam-5830	656	8	in	in	ADP
bam-5830	656	9	skeletal	skeletal	ADJ
bam-5830	656	10	muscle	muscle	NOUN
bam-5830	656	11	to	to	PART
bam-5830	656	12	maintain	maintain	VERB
bam-5830	656	13	muscle	muscle	NOUN
bam-5830	656	14	integrity	integrity	NOUN
bam-5830	656	15	and	and	CCONJ
bam-5830	656	16	a	a	DET
bam-5830	656	17	proper	proper	ADJ
bam-5830	656	18	response	response	NOUN
bam-5830	656	19	upon	upon	SCONJ
bam-5830	656	20	os	os	NOUN
bam-5830	656	21	.	.	PUNCT
bam-5830	657	1	current	current	ADJ
bam-5830	657	2	studies	study	NOUN
bam-5830	657	3	are	be	AUX
bam-5830	657	4	focused	focus	VERB
bam-5830	657	5	on	on	ADP
bam-5830	657	6	the	the	DET
bam-5830	657	7	identification	identification	NOUN
bam-5830	657	8	of	of	ADP
bam-5830	657	9	hdac4	hdac4	NOUN
bam-5830	657	10	targets	target	NOUN
bam-5830	657	11	in	in	ADP
bam-5830	657	12	the	the	DET
bam-5830	657	13	os	os	ADJ
bam-5830	657	14	response	response	NOUN
bam-5830	657	15	in	in	ADP
bam-5830	657	16	skeletal	skeletal	ADJ
bam-5830	657	17	muscle	muscle	NOUN
bam-5830	657	18	1	1	NUM
bam-5830	657	19	.	.	PUNCT
bam-5830	657	20	antioxid	antioxid	VERB
bam-5830	657	21	redox	redox	NOUN
bam-5830	657	22	signal	signal	NOUN
bam-5830	657	23	.	.	PUNCT
bam-5830	658	1	2013	2013	NUM
bam-5830	658	2	oct	oct	PROPN
bam-5830	658	3	20;19(12):1362	20;19(12):1362	NUM
bam-5830	658	4	-	-	SYM
bam-5830	658	5	72	72	NUM
bam-5830	658	6	.	.	PUNCT
bam-5830	658	7	2	2	NUM
bam-5830	658	8	.	.	X
bam-5830	658	9	j	j	PROPN
bam-5830	658	10	physiol	physiol	PROPN
bam-5830	658	11	sci	sci	PROPN
bam-5830	658	12	2010	2010	NUM
bam-5830	658	13	60	60	NUM
bam-5830	658	14	,	,	PUNCT
bam-5830	658	15	5	5	NUM
bam-5830	658	16	-	-	SYM
bam-5830	658	17	57	57	NUM
bam-5830	658	18	.	.	PUNCT
bam-5830	659	1	3	3	X
bam-5830	659	2	.	.	X
bam-5830	659	3	pediatr	pediatr	PROPN
bam-5830	659	4	res	re	NOUN
bam-5830	659	5	dec	dec	PROPN
bam-5830	659	6	;	;	PUNCT
bam-5830	659	7	2004	2004	NUM
bam-5830	659	8	56(6):878	56(6):878	NUM
bam-5830	659	9	-	-	SYM
bam-5830	659	10	82	82	NUM
bam-5830	659	11	.	.	NOUN
bam-5830	660	1	4	4	X
bam-5830	660	2	.	.	X
bam-5830	660	3	free	free	ADJ
bam-5830	660	4	radic	radic	ADJ
bam-5830	660	5	res	re	NOUN
bam-5830	660	6	.	.	PUNCT
bam-5830	660	7	2010	2010	NUM
bam-5830	660	8	may;44(5):563	may;44(5):563	NOUN
bam-5830	660	9	-	-	PUNCT
bam-5830	660	10	76	76	NUM
bam-5830	660	11	.	.	PUNCT
bam-5830	661	1	5	5	NUM
bam-5830	661	2	.	.	X
bam-5830	661	3	j	j	PROPN
bam-5830	661	4	clin	clin	PROPN
bam-5830	661	5	invest	invest	PROPN
bam-5830	661	6	.	.	PUNCT
bam-5830	662	1	2013	2013	NUM
bam-5830	662	2	mar;123(3):1359	mar;123(3):1359	NOUN
bam-5830	662	3	-	-	PUNCT
bam-5830	662	4	70	70	NUM
bam-5830	662	5	.	.	PUNCT
bam-5830	663	1	6	6	NUM
bam-5830	663	2	.	.	X
bam-5830	663	3	j	j	PROPN
bam-5830	663	4	clin	clin	PROPN
bam-5830	663	5	invest	invest	PROPN
bam-5830	663	6	.	.	PUNCT
bam-5830	664	1	2007	2007	NUM
bam-5830	664	2	sep;117(9):2459	sep;117(9):2459	PROPN
bam-5830	664	3	-	-	PUNCT
bam-5830	664	4	67	67	NUM
bam-5830	664	5	.	.	PUNCT
bam-5830	664	6	7	7	X
bam-5830	664	7	.	.	X
bam-5830	664	8	cell	cell	NOUN
bam-5830	664	9	.	.	PUNCT
bam-5830	665	1	2004	2004	NUM
bam-5830	665	2	nov	nov	NOUN
bam-5830	665	3	12;119(4):55566	12;119(4):55566	NUM
bam-5830	665	4	.	.	NOUN
bam-5830	665	5	8	8	NUM
bam-5830	665	6	.	.	PUNCT
bam-5830	666	1	science	science	NOUN
bam-5830	666	2	.	.	PUNCT
bam-5830	667	1	2009	2009	NUM
bam-5830	667	2	dec	dec	PROPN
bam-5830	667	3	11;326(5959):1549	11;326(5959):1549	NUM
bam-5830	667	4	-	-	SYM
bam-5830	667	5	54	54	NUM
bam-5830	667	6	.	.	PUNCT
bam-5830	667	7	9	9	X
bam-5830	667	8	.	.	X
bam-5830	667	9	cell	cell	NOUN
bam-5830	667	10	.	.	PUNCT
bam-5830	668	1	2010	2010	NUM
bam-5830	668	2	oct	oct	NOUN
bam-5830	668	3	1;143(1):35	1;143(1):35	PROPN
bam-5830	668	4	-	-	SYM
bam-5830	668	5	45	45	NUM
bam-5830	668	6	.	.	NOUN
bam-5830	668	7	10	10	NUM
bam-5830	668	8	.	.	X
bam-5830	668	9	nature	nature	NOUN
bam-5830	668	10	2000;408:106	2000;408:106	NUM
bam-5830	668	11	-	-	SYM
bam-5830	668	12	11	11	NUM
bam-5830	668	13	.	.	PUNCT
bam-5830	669	1	*	*	PUNCT
bam-5830	669	2	*	*	PUNCT
bam-5830	669	3	*	*	PUNCT
bam-5830	669	4	*	*	PUNCT
bam-5830	669	5	*	*	PUNCT
bam-5830	669	6	collagen	collagen	PROPN
bam-5830	669	7	vi	vi	PROPN
bam-5830	669	8	,	,	PUNCT
bam-5830	669	9	a	a	DET
bam-5830	669	10	key	key	ADJ
bam-5830	669	11	extracellular	extracellular	ADJ
bam-5830	669	12	matrix	matrix	NOUN
bam-5830	669	13	protein	protein	NOUN
bam-5830	669	14	at	at	ADP
bam-5830	669	15	the	the	DET
bam-5830	669	16	crossroad	crossroad	NOUN
bam-5830	669	17	of	of	ADP
bam-5830	669	18	skeletal	skeletal	ADJ
bam-5830	669	19	muscle	muscle	NOUN
bam-5830	669	20	and	and	CCONJ
bam-5830	669	21	peripheral	peripheral	ADJ
bam-5830	669	22	nerves	nerve	NOUN
bam-5830	669	23	m.	m.	NOUN
bam-5830	669	24	cescon	cescon	NOUN
bam-5830	669	25	1	1	NUM
bam-5830	669	26	,	,	PUNCT
bam-5830	669	27	f.	f.	PROPN
bam-5830	669	28	gattazzo	gattazzo	PROPN
bam-5830	669	29	1	1	NUM
bam-5830	669	30	,	,	PUNCT
bam-5830	669	31	p.	p.	NOUN
bam-5830	669	32	sabatelli	sabatelli	PROPN
bam-5830	669	33	2	2	NUM
bam-5830	669	34	,	,	PUNCT
bam-5830	669	35	a.	a.	NOUN
bam-5830	669	36	megighian	megighian	NOUN
bam-5830	669	37	3	3	NUM
bam-5830	669	38	,	,	PUNCT
bam-5830	669	39	s.	s.	PROPN
bam-5830	669	40	hashemolhosseini	hashemolhosseini	PROPN
bam-5830	669	41	4	4	NUM
bam-5830	669	42	,	,	PUNCT
bam-5830	669	43	p.	p.	NOUN
bam-5830	669	44	bonaldo	bonaldo	ADJ
bam-5830	670	1	1	1	NUM
bam-5830	670	2	1	1	NUM
bam-5830	670	3	.	.	PUNCT
bam-5830	670	4	department	department	NOUN
bam-5830	670	5	of	of	ADP
bam-5830	670	6	molecular	molecular	ADJ
bam-5830	670	7	medicine	medicine	NOUN
bam-5830	670	8	,	,	PUNCT
bam-5830	670	9	university	university	NOUN
bam-5830	670	10	of	of	ADP
bam-5830	670	11	padova	padova	PROPN
bam-5830	670	12	,	,	PUNCT
bam-5830	670	13	italy	italy	PROPN
bam-5830	670	14	;	;	PUNCT
bam-5830	670	15	2	2	X
bam-5830	670	16	.	.	X
bam-5830	670	17	institute	institute	NOUN
bam-5830	670	18	of	of	ADP
bam-5830	670	19	molecular	molecular	ADJ
bam-5830	670	20	genetics	genetic	NOUN
bam-5830	670	21	-	-	PUNCT
bam-5830	670	22	cnr	cnr	PROPN
bam-5830	670	23	,	,	PUNCT
bam-5830	670	24	ior	ior	PROPN
bam-5830	670	25	,	,	PUNCT
bam-5830	670	26	bologna	bologna	PROPN
bam-5830	670	27	,	,	PUNCT
bam-5830	670	28	italy	italy	PROPN
bam-5830	670	29	;	;	PUNCT
bam-5830	670	30	3	3	X
bam-5830	670	31	.	.	X
bam-5830	670	32	department	department	PROPN
bam-5830	670	33	of	of	ADP
bam-5830	670	34	biomedical	biomedical	ADJ
bam-5830	670	35	sciences	sciences	PROPN
bam-5830	670	36	,	,	PUNCT
bam-5830	670	37	university	university	NOUN
bam-5830	670	38	of	of	ADP
bam-5830	670	39	padova	padova	PROPN
bam-5830	670	40	,	,	PUNCT
bam-5830	670	41	italy	italy	PROPN
bam-5830	670	42	;	;	PUNCT
bam-5830	670	43	4	4	X
bam-5830	670	44	.	.	X
bam-5830	670	45	institut	institut	PROPN
bam-5830	670	46	für	für	PROPN
bam-5830	670	47	biochemie	biochemie	PROPN
bam-5830	670	48	,	,	PUNCT
bam-5830	670	49	friedrich	friedrich	ADJ
bam-5830	670	50	-	-	PUNCT
bam-5830	670	51	alexanderuniversität	alexanderuniversität	NOUN
bam-5830	670	52	erlangen	erlangen	PROPN
bam-5830	670	53	-	-	PUNCT
bam-5830	670	54	nürnberg	nürnberg	PROPN
bam-5830	670	55	,	,	PUNCT
bam-5830	670	56	erlangen	erlangen	PROPN
bam-5830	670	57	,	,	PUNCT
bam-5830	670	58	germany	germany	PROPN
bam-5830	670	59	e	e	PROPN
bam-5830	670	60	-	-	NOUN
bam-5830	670	61	mail	mail	NOUN
bam-5830	670	62	:	:	PUNCT
bam-5830	670	63	matilde.cescon@unipd.it	matilde.cescon@unipd.it	PROPN
bam-5830	670	64	collagen	collagen	PROPN
bam-5830	670	65	vi	vi	PROPN
bam-5830	670	66	(	(	PUNCT
bam-5830	670	67	colvi	colvi	PROPN
bam-5830	670	68	)	)	PUNCT
bam-5830	670	69	is	be	AUX
bam-5830	670	70	a	a	DET
bam-5830	670	71	major	major	ADJ
bam-5830	670	72	extracellular	extracellular	ADJ
bam-5830	670	73	matrix	matrix	NOUN
bam-5830	670	74	component	component	NOUN
bam-5830	670	75	made	make	VERB
bam-5830	670	76	of	of	ADP
bam-5830	670	77	three	three	NUM
bam-5830	670	78	genetically	genetically	ADV
bam-5830	670	79	distinct	distinct	ADJ
bam-5830	670	80			NOUN
bam-5830	670	81	chains	chain	NOUN
bam-5830	670	82	and	and	CCONJ
bam-5830	670	83	abundantly	abundantly	ADV
bam-5830	670	84	deposited	deposit	VERB
bam-5830	670	85	in	in	ADP
bam-5830	670	86	the	the	DET
bam-5830	670	87	basement	basement	NOUN
bam-5830	670	88	membrane	membrane	NOUN
bam-5830	670	89	of	of	ADP
bam-5830	670	90	both	both	PRON
bam-5830	670	91	skeletal	skeletal	ADJ
bam-5830	670	92	muscles	muscle	NOUN
bam-5830	670	93	and	and	CCONJ
bam-5830	670	94	peripheral	peripheral	ADJ
bam-5830	670	95	nerves	nerve	NOUN
bam-5830	670	96	.	.	PUNCT
bam-5830	671	1	mutations	mutation	NOUN
bam-5830	671	2	in	in	ADP
bam-5830	671	3	col6a1	col6a1	NOUN
bam-5830	671	4	,	,	PUNCT
bam-5830	671	5	col6a2	col6a2	NOUN
bam-5830	671	6	and	and	CCONJ
bam-5830	671	7	col6a3	col6a3	NOUN
bam-5830	671	8	genes	gene	NOUN
bam-5830	671	9	are	be	AUX
bam-5830	671	10	known	know	VERB
bam-5830	671	11	to	to	PART
bam-5830	671	12	cause	cause	VERB
bam-5830	671	13	different	different	ADJ
bam-5830	671	14	forms	form	NOUN
bam-5830	671	15	of	of	ADP
bam-5830	671	16	muscle	muscle	NOUN
bam-5830	671	17	diseases	disease	NOUN
bam-5830	671	18	,	,	PUNCT
bam-5830	671	19	including	include	VERB
bam-5830	671	20	bethlem	bethlem	ADJ
bam-5830	671	21	myopathy	myopathy	ADJ
bam-5830	671	22	,	,	PUNCT
bam-5830	671	23	ullrich	ullrich	PROPN
bam-5830	671	24	congenital	congenital	ADJ
bam-5830	671	25	muscular	muscular	ADJ
bam-5830	671	26	dystrophy	dystrophy	NOUN
bam-5830	671	27	and	and	CCONJ
bam-5830	671	28	myosclerosis	myosclerosis	NOUN
bam-5830	671	29	myopathy	myopathy	ADJ
bam-5830	671	30	.	.	PUNCT
bam-5830	672	1	colvi	colvi	PROPN
bam-5830	672	2	null	null	NOUN
bam-5830	672	3	(	(	PUNCT
bam-5830	672	4	col6a1–/	col6a1–/	ADJ
bam-5830	672	5	–	–	PUNCT
bam-5830	672	6	)	)	PUNCT
bam-5830	672	7	mice	mouse	NOUN
bam-5830	672	8	display	display	VERB
bam-5830	672	9	a	a	DET
bam-5830	672	10	myopathic	myopathic	ADJ
bam-5830	672	11	phenotype	phenotype	NOUN
bam-5830	672	12	characterized	characterize	VERB
bam-5830	672	13	by	by	ADP
bam-5830	672	14	latent	latent	ADJ
bam-5830	672	15	mitochondrial	mitochondrial	ADJ
bam-5830	672	16	dysfunction	dysfunction	NOUN
bam-5830	672	17	,	,	PUNCT
bam-5830	672	18	spontaneous	spontaneous	ADJ
bam-5830	672	19	apoptosis	apoptosis	NOUN
bam-5830	672	20	,	,	PUNCT
bam-5830	672	21	defective	defective	ADJ
bam-5830	672	22	autophagy	autophagy	ADJ
bam-5830	672	23	regulation	regulation	NOUN
bam-5830	672	24	and	and	CCONJ
bam-5830	672	25	compromised	compromise	VERB
bam-5830	672	26	muscle	muscle	NOUN
bam-5830	672	27	regeneration	regeneration	NOUN
bam-5830	672	28	.	.	PUNCT
bam-5830	673	1	we	we	PRON
bam-5830	673	2	recently	recently	ADV
bam-5830	673	3	demonstrated	demonstrate	VERB
bam-5830	673	4	that	that	SCONJ
bam-5830	673	5	the	the	DET
bam-5830	673	6	absence	absence	NOUN
bam-5830	673	7	of	of	ADP
bam-5830	673	8	colvi	colvi	PROPN
bam-5830	673	9	in	in	ADP
bam-5830	673	10	peripheral	peripheral	ADJ
bam-5830	673	11	nerves	nerve	NOUN
bam-5830	673	12	leads	lead	VERB
bam-5830	673	13	to	to	ADP
bam-5830	673	14	hypermyelination	hypermyelination	NOUN
bam-5830	673	15	,	,	PUNCT
bam-5830	673	16	altered	alter	VERB
bam-5830	673	17	remak	remak	NOUN
bam-5830	673	18	bundles	bundle	NOUN
bam-5830	673	19	,	,	PUNCT
bam-5830	673	20	sensory	sensory	ADJ
bam-5830	673	21	-	-	PUNCT
bam-5830	673	22	motor	motor	NOUN
bam-5830	673	23	functional	functional	ADJ
bam-5830	673	24	deficits	deficit	NOUN
bam-5830	673	25	and	and	CCONJ
bam-5830	673	26	decreased	decrease	VERB
bam-5830	673	27	nerve	nerve	NOUN
bam-5830	673	28	conduction	conduction	NOUN
bam-5830	673	29	velocities	velocity	NOUN
bam-5830	673	30	,	,	PUNCT
bam-5830	673	31	thus	thus	ADV
bam-5830	673	32	pointing	point	VERB
bam-5830	673	33	at	at	ADP
bam-5830	673	34	colvi	colvi	PROPN
bam-5830	673	35	as	as	ADP
bam-5830	673	36	a	a	DET
bam-5830	673	37	crucial	crucial	ADJ
bam-5830	673	38	molecule	molecule	NOUN
bam-5830	673	39	for	for	ADP
bam-5830	673	40	peripheral	peripheral	ADJ
bam-5830	673	41	nerve	nerve	NOUN
bam-5830	673	42	structure	structure	NOUN
bam-5830	673	43	and	and	CCONJ
bam-5830	673	44	function	function	NOUN
bam-5830	673	45	.	.	PUNCT
bam-5830	674	1	given	give	VERB
bam-5830	674	2	the	the	DET
bam-5830	674	3	muscle	muscle	NOUN
bam-5830	674	4	and	and	CCONJ
bam-5830	674	5	nerve	nerve	NOUN
bam-5830	674	6	defects	defect	NOUN
bam-5830	674	7	displayed	display	VERB
bam-5830	674	8	by	by	ADP
bam-5830	674	9	col6a1	col6a1	NOUN
bam-5830	674	10	null	null	ADJ
bam-5830	674	11	mice	mouse	NOUN
bam-5830	674	12	,	,	PUNCT
bam-5830	674	13	we	we	PRON
bam-5830	674	14	decided	decide	VERB
bam-5830	674	15	to	to	PART
bam-5830	674	16	explore	explore	VERB
bam-5830	674	17	the	the	DET
bam-5830	674	18	role	role	NOUN
bam-5830	674	19	of	of	ADP
bam-5830	674	20	colvi	colvi	PROPN
bam-5830	674	21	in	in	ADP
bam-5830	674	22	the	the	DET
bam-5830	674	23	neuromuscular	neuromuscular	ADJ
bam-5830	674	24	junction	junction	NOUN
bam-5830	674	25	(	(	PUNCT
bam-5830	674	26	nmj	nmj	NOUN
bam-5830	674	27	)	)	PUNCT
bam-5830	674	28	.	.	PUNCT
bam-5830	675	1	our	our	PRON
bam-5830	675	2	unpublished	unpublished	ADJ
bam-5830	675	3	studies	study	NOUN
bam-5830	675	4	revealed	reveal	VERB
bam-5830	675	5	that	that	SCONJ
bam-5830	675	6	colvi	colvi	PROPN
bam-5830	675	7	is	be	AUX
bam-5830	675	8	indeed	indeed	ADV
bam-5830	675	9	deposited	deposit	VERB
bam-5830	675	10	at	at	ADP
bam-5830	675	11	the	the	DET
bam-5830	675	12	synapse	synapse	NOUN
bam-5830	675	13	.	.	PUNCT
bam-5830	676	1	immunofluorescence	immunofluorescence	NOUN
bam-5830	676	2	analysis	analysis	NOUN
bam-5830	676	3	showed	show	VERB
bam-5830	676	4	colvi	colvi	NOUN
bam-5830	676	5	deposition	deposition	NOUN
bam-5830	676	6	in	in	ADP
bam-5830	676	7	nmjs	nmj	NOUN
bam-5830	676	8	.	.	PUNCT
bam-5830	677	1	preliminary	preliminary	ADJ
bam-5830	677	2	results	result	NOUN
bam-5830	677	3	revealed	reveal	VERB
bam-5830	677	4	altered	altered	ADJ
bam-5830	677	5	expression	expression	NOUN
bam-5830	677	6	of	of	ADP
bam-5830	677	7	synaptic	synaptic	ADJ
bam-5830	677	8	genes	gene	NOUN
bam-5830	677	9	and	and	CCONJ
bam-5830	677	10	abnormal	abnormal	ADJ
bam-5830	677	11	electrophysiological	electrophysiological	ADJ
bam-5830	677	12	parameters	parameter	NOUN
bam-5830	677	13	in	in	ADP
bam-5830	677	14	col6a1–/	col6a1–/	NOUN
bam-5830	677	15	–	–	PUNCT
bam-5830	677	16	mice	mouse	NOUN
bam-5830	677	17	.	.	PUNCT
bam-5830	678	1	these	these	DET
bam-5830	678	2	findings	finding	NOUN
bam-5830	678	3	suggest	suggest	VERB
bam-5830	678	4	a	a	DET
bam-5830	678	5	potential	potential	ADJ
bam-5830	678	6	role	role	NOUN
bam-5830	678	7	for	for	ADP
bam-5830	678	8	colvi	colvi	PROPN
bam-5830	678	9	at	at	ADP
bam-5830	678	10	the	the	DET
bam-5830	678	11	nmj	nmj	NOUN
bam-5830	678	12	,	,	PUNCT
bam-5830	678	13	and	and	CCONJ
bam-5830	678	14	further	further	ADJ
bam-5830	678	15	studies	study	NOUN
bam-5830	678	16	will	will	AUX
bam-5830	678	17	allow	allow	VERB
bam-5830	678	18	shedding	shed	VERB
bam-5830	678	19	new	new	ADJ
bam-5830	678	20	light	light	NOUN
bam-5830	678	21	on	on	ADP
bam-5830	678	22	the	the	DET
bam-5830	678	23	roles	role	NOUN
bam-5830	678	24	of	of	ADP
bam-5830	678	25	this	this	DET
bam-5830	678	26	extracellular	extracellular	ADJ
bam-5830	678	27	matrix	matrix	NOUN
bam-5830	678	28	component	component	NOUN
bam-5830	678	29	in	in	ADP
bam-5830	678	30	the	the	DET
bam-5830	678	31	nerve	nerve	NOUN
bam-5830	678	32	/	/	SYM
bam-5830	678	33	muscle	muscle	NOUN
bam-5830	678	34	axis	axis	NOUN
bam-5830	678	35	.	.	PUNCT
bam-5830	679	1	*	*	PUNCT
bam-5830	679	2	*	*	PUNCT
bam-5830	679	3	*	*	PUNCT
bam-5830	679	4	*	*	PUNCT
bam-5830	679	5	*	*	PUNCT
bam-5830	679	6	mir-143	mir-143	PROPN
bam-5830	679	7	is	be	AUX
bam-5830	679	8	activated	activate	VERB
bam-5830	679	9	under	under	ADP
bam-5830	679	10	tsa	tsa	NOUN
bam-5830	679	11	conditions	condition	NOUN
bam-5830	679	12	and	and	CCONJ
bam-5830	679	13	helps	help	VERB
bam-5830	679	14	cells	cell	NOUN
bam-5830	679	15	to	to	PART
bam-5830	679	16	choose	choose	VERB
bam-5830	679	17	an	an	DET
bam-5830	679	18	anti	anti	ADJ
bam-5830	679	19	-	-	ADJ
bam-5830	679	20	adipogenic	adipogenic	ADJ
bam-5830	679	21	fate	fate	PROPN
bam-5830	679	22	c.	c.	PROPN
bam-5830	679	23	sanchez	sanchez	PROPN
bam-5830	679	24	-	-	PUNCT
bam-5830	679	25	riera	riera	PROPN
bam-5830	679	26	1	1	NUM
bam-5830	679	27	,	,	PUNCT
bam-5830	679	28	v.	v.	ADP
bam-5830	679	29	saccone	saccone	NOUN
bam-5830	679	30	1	1	NUM
bam-5830	679	31	,	,	PUNCT
bam-5830	679	32	s.	s.	PROPN
bam-5830	679	33	consalvi	consalvi	PROPN
bam-5830	679	34	1	1	NUM
bam-5830	679	35	,	,	PUNCT
bam-5830	679	36	l.	l.	PROPN
bam-5830	679	37	madaro	madaro	PROPN
bam-5830	679	38	1	1	NUM
bam-5830	679	39	,	,	PUNCT
bam-5830	679	40	a.	a.	PROPN
bam-5830	679	41	lahm	lahm	PROPN
bam-5830	679	42	1	1	NUM
bam-5830	679	43	,	,	PUNCT
bam-5830	679	44	l.	l.	PROPN
bam-5830	679	45	guido	guido	PROPN
bam-5830	679	46	1	1	NUM
bam-5830	679	47	,	,	PUNCT
bam-5830	679	48	p.l	p.l	PROPN
bam-5830	680	1	.	.	PROPN
bam-5830	680	2	puri	puri	PROPN
bam-5830	680	3	1,2	1,2	NUM
bam-5830	680	4	e	e	NOUN
bam-5830	680	5	-	-	NOUN
bam-5830	680	6	mail	mail	NOUN
bam-5830	680	7	:	:	PUNCT
bam-5830	680	8	c.sanchezriera@hsantalucia.it	c.sanchezriera@hsantalucia.it	PRON
bam-5830	680	9	1	1	NUM
bam-5830	680	10	laboratory	laboratory	NOUN
bam-5830	680	11	of	of	ADP
bam-5830	680	12	epigenetics	epigenetic	NOUN
bam-5830	680	13	and	and	CCONJ
bam-5830	680	14	regenerative	regenerative	ADJ
bam-5830	680	15	pharmacology	pharmacology	NOUN
bam-5830	680	16	,	,	PUNCT
bam-5830	680	17	fondazione	fondazione	PROPN
bam-5830	680	18	santa	santa	PROPN
bam-5830	680	19	lucia	lucia	PROPN
bam-5830	680	20	,	,	PUNCT
bam-5830	680	21	rome	rome	PROPN
bam-5830	680	22	,	,	PUNCT
bam-5830	680	23	italy	italy	PROPN
bam-5830	680	24	;	;	PUNCT
bam-5830	680	25	2	2	NUM
bam-5830	680	26	sanford	sanford	PROPN
bam-5830	680	27	-	-	PUNCT
bam-5830	680	28	burnham	burnham	PROPN
bam-5830	680	29	medical	medical	PROPN
bam-5830	680	30	research	research	PROPN
bam-5830	680	31	institute	institute	PROPN
bam-5830	680	32	,	,	PUNCT
bam-5830	680	33	sanford	sanford	PROPN
bam-5830	680	34	children	children	PROPN
bam-5830	680	35	’s	’s	PART
bam-5830	680	36	health	health	NOUN
bam-5830	680	37	research	research	NOUN
bam-5830	680	38	center	center	NOUN
bam-5830	680	39	,	,	PUNCT
bam-5830	680	40	la	la	PROPN
bam-5830	680	41	jolla	jolla	PROPN
bam-5830	680	42	,	,	PUNCT
bam-5830	680	43	california	california	PROPN
bam-5830	680	44	,	,	PUNCT
bam-5830	680	45	usa	usa	PROPN
bam-5830	680	46	muscular	muscular	PROPN
bam-5830	680	47	dystrophies	dystrophy	NOUN
bam-5830	680	48	are	be	AUX
bam-5830	680	49	non	non	ADJ
bam-5830	680	50	curable	curable	ADJ
bam-5830	680	51	diseases	disease	NOUN
bam-5830	680	52	.	.	PUNCT
bam-5830	681	1	recently	recently	ADV
bam-5830	681	2	,	,	PUNCT
bam-5830	681	3	new	new	ADJ
bam-5830	681	4	strategies	strategy	NOUN
bam-5830	681	5	shed	shed	VERB
bam-5830	681	6	light	light	NOUN
bam-5830	681	7	to	to	ADP
bam-5830	681	8	an	an	DET
bam-5830	681	9	increase	increase	NOUN
bam-5830	681	10	of	of	ADP
bam-5830	681	11	muscle	muscle	NOUN
bam-5830	681	12	regeneration	regeneration	NOUN
bam-5830	681	13	.	.	PUNCT
bam-5830	682	1	these	these	DET
bam-5830	682	2	strategies	strategy	NOUN
bam-5830	682	3	focus	focus	VERB
bam-5830	682	4	on	on	ADP
bam-5830	682	5	epigenetic	epigenetic	ADJ
bam-5830	682	6	drugs	drug	NOUN
bam-5830	682	7	.	.	PUNCT
bam-5830	683	1	tsa	tsa	NOUN
bam-5830	683	2	(	(	PUNCT
bam-5830	683	3	hdaci	hdaci	NOUN
bam-5830	683	4	)	)	PUNCT
bam-5830	683	5	achieve	achieve	VERB
bam-5830	683	6	to	to	PART
bam-5830	683	7	enhance	enhance	VERB
bam-5830	683	8	the	the	DET
bam-5830	683	9	regeneration	regeneration	NOUN
bam-5830	683	10	rate	rate	NOUN
bam-5830	683	11	in	in	ADP
bam-5830	683	12	both	both	DET
bam-5830	683	13	mice	mouse	NOUN
bam-5830	683	14	and	and	CCONJ
bam-5830	683	15	humans	human	NOUN
bam-5830	683	16	.	.	PUNCT
bam-5830	684	1	however	however	ADV
bam-5830	684	2	,	,	PUNCT
bam-5830	684	3	new	new	ADJ
bam-5830	684	4	challenges	challenge	NOUN
bam-5830	684	5	stay	stay	VERB
bam-5830	684	6	on	on	ADP
bam-5830	684	7	the	the	DET
bam-5830	684	8	horizon	horizon	NOUN
bam-5830	684	9	.	.	PUNCT
bam-5830	685	1	monitoring	monitor	VERB
bam-5830	685	2	and	and	CCONJ
bam-5830	685	3	controlling	control	VERB
bam-5830	685	4	the	the	DET
bam-5830	685	5	changes	change	NOUN
bam-5830	685	6	of	of	ADP
bam-5830	685	7	the	the	DET
bam-5830	685	8	treatment	treatment	NOUN
bam-5830	685	9	in	in	ADP
bam-5830	685	10	muscle	muscle	NOUN
bam-5830	685	11	without	without	ADP
bam-5830	685	12	invasive	invasive	ADJ
bam-5830	685	13	techniques	technique	NOUN
bam-5830	685	14	are	be	AUX
bam-5830	685	15	one	one	NUM
bam-5830	685	16	of	of	ADP
bam-5830	685	17	that	that	PRON
bam-5830	685	18	’s	’s	NOUN
bam-5830	685	19	.	.	PUNCT
bam-5830	686	1	in	in	ADP
bam-5830	686	2	our	our	PRON
bam-5830	686	3	research	research	NOUN
bam-5830	686	4	we	we	PRON
bam-5830	686	5	identified	identify	VERB
bam-5830	686	6	seven	seven	NUM
bam-5830	686	7	micrornas	microrna	NOUN
bam-5830	686	8	differential	differential	NOUN
bam-5830	686	9	expressed	express	VERB
bam-5830	686	10	in	in	ADP
bam-5830	686	11	faps	fap	NOUN
bam-5830	686	12	population	population	NOUN
bam-5830	686	13	.	.	PUNCT
bam-5830	687	1	faps	fap	NOUN
bam-5830	687	2	are	be	AUX
bam-5830	687	3	key	key	ADJ
bam-5830	687	4	players	player	NOUN
bam-5830	687	5	of	of	ADP
bam-5830	687	6	muscle	muscle	NOUN
bam-5830	687	7	regeneration	regeneration	NOUN
bam-5830	687	8	under	under	ADP
bam-5830	687	9	hdaci	hdaci	NOUN
bam-5830	687	10	treatment	treatment	NOUN
bam-5830	687	11	.	.	PUNCT
bam-5830	688	1	from	from	ADP
bam-5830	688	2	these	these	DET
bam-5830	688	3	seven	seven	NUM
bam-5830	688	4	microrna	microrna	PROPN
bam-5830	688	5	,	,	PUNCT
bam-5830	688	6	mir-143	mir-143	PROPN
bam-5830	688	7	has	have	AUX
bam-5830	688	8	been	be	AUX
bam-5830	688	9	validated	validate	VERB
bam-5830	688	10	with	with	ADP
bam-5830	688	11	qrt	qrt	NOUN
bam-5830	688	12	-	-	PUNCT
bam-5830	688	13	pcr	pcr	ADJ
bam-5830	688	14	,	,	PUNCT
bam-5830	688	15	and	and	CCONJ
bam-5830	688	16	chip	chip	NOUN
bam-5830	688	17	techniques	technique	NOUN
bam-5830	688	18	.	.	PUNCT
bam-5830	689	1	this	this	DET
bam-5830	689	2	mir-143	mir-143	NOUN
bam-5830	689	3	form	form	VERB
bam-5830	689	4	part	part	NOUN
bam-5830	689	5	of	of	ADP
bam-5830	689	6	a	a	DET
bam-5830	689	7	cluster	cluster	NOUN
bam-5830	689	8	with	with	ADP
bam-5830	689	9	mir-145	mir-145	NOUN
bam-5830	689	10	that	that	PRON
bam-5830	689	11	locates	locate	VERB
bam-5830	689	12	into	into	ADP
bam-5830	689	13	a	a	DET
bam-5830	689	14	long	long	ADJ
bam-5830	689	15	non	non	ADJ
bam-5830	689	16	coding	code	VERB
bam-5830	689	17	rna	rna	NOUN
bam-5830	689	18	non	non	NOUN
bam-5830	689	19	characterized	characterize	VERB
bam-5830	689	20	until	until	ADP
bam-5830	689	21	that	that	DET
bam-5830	689	22	moment	moment	NOUN
bam-5830	689	23	.	.	PUNCT
bam-5830	690	1	the	the	DET
bam-5830	690	2	overexpression	overexpression	NOUN
bam-5830	690	3	of	of	ADP
bam-5830	690	4	this	this	DET
bam-5830	690	5	mir-143	mir-143	NOUN
bam-5830	690	6	turns	turn	VERB
bam-5830	690	7	faps	fap	NOUN
bam-5830	690	8	into	into	ADP
bam-5830	690	9	a	a	DET
bam-5830	690	10	non	non	X
bam-5830	690	11	adipogenic	adipogenic	ADJ
bam-5830	690	12	phenotype	phenotype	NOUN
bam-5830	690	13	,	,	PUNCT
bam-5830	690	14	whereas	whereas	SCONJ
bam-5830	690	15	the	the	DET
bam-5830	690	16	inhibition	inhibition	NOUN
bam-5830	690	17	of	of	ADP
bam-5830	690	18	it	it	PRON
bam-5830	690	19	recovershe	recovershe	ADJ
bam-5830	690	20	adipogenic	adipogenic	ADJ
bam-5830	690	21	behavior	behavior	NOUN
bam-5830	690	22	.	.	PUNCT
bam-5830	691	1	thus	thus	ADV
bam-5830	691	2	,	,	PUNCT
bam-5830	691	3	in	in	ADP
bam-5830	691	4	this	this	DET
bam-5830	691	5	work	work	NOUN
bam-5830	691	6	we	we	PRON
bam-5830	691	7	are	be	AUX
bam-5830	691	8	trying	try	VERB
bam-5830	691	9	to	to	PART
bam-5830	691	10	characterize	characterize	VERB
bam-5830	691	11	the	the	DET
bam-5830	691	12	role	role	NOUN
bam-5830	691	13	of	of	ADP
bam-5830	691	14	this	this	DET
bam-5830	691	15	microrna	microrna	PROPN
bam-5830	691	16	and	and	CCONJ
bam-5830	691	17	their	their	PRON
bam-5830	691	18	host	host	NOUN
bam-5830	691	19	gene	gene	NOUN
bam-5830	691	20	to	to	PART
bam-5830	691	21	understand	understand	VERB
bam-5830	691	22	if	if	SCONJ
bam-5830	691	23	it	it	PRON
bam-5830	691	24	could	could	AUX
bam-5830	691	25	be	be	AUX
bam-5830	691	26	a	a	DET
bam-5830	691	27	good	good	ADJ
bam-5830	691	28	candidate	candidate	NOUN
bam-5830	691	29	to	to	PART
bam-5830	691	30	be	be	AUX
bam-5830	691	31	used	use	VERB
bam-5830	691	32	as	as	ADP
bam-5830	691	33	marker	marker	NOUN
bam-5830	691	34	during	during	ADP
bam-5830	691	35	the	the	DET
bam-5830	691	36	treatment	treatment	NOUN
bam-5830	691	37	.	.	PUNCT
bam-5830	692	1	*	*	PUNCT
bam-5830	692	2	*	*	PUNCT
bam-5830	692	3	*	*	PUNCT
bam-5830	692	4	*	*	PUNCT
bam-5830	692	5	*	*	PUNCT
bam-5830	692	6	characterization	characterization	NOUN
bam-5830	692	7	of	of	ADP
bam-5830	692	8	a	a	DET
bam-5830	692	9	nuclear	nuclear	ADJ
bam-5830	692	10	lncrna	lncrna	NOUN
bam-5830	692	11	involved	involve	VERB
bam-5830	692	12	in	in	ADP
bam-5830	692	13	skeletal	skeletal	ADJ
bam-5830	692	14	and	and	CCONJ
bam-5830	692	15	cardiac	cardiac	ADJ
bam-5830	692	16	muscle	muscle	NOUN
bam-5830	692	17	differentiation	differentiation	NOUN
bam-5830	692	18	a.	a.	NOUN
bam-5830	692	19	cipriano	cipriano	PROPN
bam-5830	692	20	1	1	NUM
bam-5830	692	21	,	,	PUNCT
bam-5830	692	22	r.tita	r.tita	X
bam-5830	692	23	1	1	NUM
bam-5830	692	24	,	,	PUNCT
bam-5830	692	25	l.	l.	PROPN
bam-5830	692	26	bisceglie	bisceglie	PROPN
bam-5830	692	27	1	1	NUM
bam-5830	692	28	,	,	PUNCT
bam-5830	692	29	m.ballarino	m.ballarino	PRON
bam-5830	692	30	1	1	NUM
bam-5830	692	31	,	,	PUNCT
bam-5830	692	32	i.	i.	PROPN
bam-5830	692	33	bozzoni	bozzoni	PROPN
bam-5830	692	34	1,2,3	1,2,3	NUM
bam-5830	692	35	1	1	NUM
bam-5830	692	36	department	department	NOUN
bam-5830	692	37	of	of	ADP
bam-5830	692	38	biology	biology	NOUN
bam-5830	692	39	and	and	CCONJ
bam-5830	692	40	biotechnology	biotechnology	NOUN
bam-5830	692	41	charles	charles	PROPN
bam-5830	692	42	darwin	darwin	PROPN
bam-5830	692	43	,	,	PUNCT
bam-5830	692	44	sapienza	sapienza	PROPN
bam-5830	692	45	university	university	PROPN
bam-5830	692	46	of	of	ADP
bam-5830	692	47	rome	rome	PROPN
bam-5830	692	48	,	,	PUNCT
bam-5830	692	49	italy	italy	PROPN
bam-5830	692	50	;	;	PUNCT
bam-5830	692	51	2	2	X
bam-5830	692	52	.	.	X
bam-5830	692	53	center	center	NOUN
bam-5830	692	54	for	for	ADP
bam-5830	692	55	life	life	NOUN
bam-5830	692	56	nano	nano	NOUN
bam-5830	692	57	science@sapienza	science@sapienza	NOUN
bam-5830	692	58	,	,	PUNCT
bam-5830	692	59	istituto	istituto	X
bam-5830	692	60	italiano	italiano	NOUN
bam-5830	692	61	di	di	X
bam-5830	692	62	tecnologia	tecnologia	PROPN
bam-5830	692	63	,	,	PUNCT
bam-5830	692	64	rome	rome	PROPN
bam-5830	692	65	,	,	PUNCT
bam-5830	692	66	italy	italy	PROPN
bam-5830	692	67	;	;	PUNCT
bam-5830	692	68	3	3	X
bam-5830	692	69	.	.	X
bam-5830	692	70	institute	institute	PROPN
bam-5830	692	71	pasteur	pasteur	PROPN
bam-5830	692	72	fondazione	fondazione	PROPN
bam-5830	692	73	cenci	cenci	PROPN
bam-5830	692	74	-	-	PUNCT
bam-5830	692	75	bolognetti	bolognetti	PROPN
bam-5830	692	76	and	and	CCONJ
bam-5830	692	77	ibpm	ibpm	PROPN
bam-5830	692	78	,	,	PUNCT
bam-5830	692	79	sapienza	sapienza	PROPN
bam-5830	692	80	university	university	PROPN
bam-5830	692	81	of	of	ADP
bam-5830	692	82	rome	rome	PROPN
bam-5830	692	83	,	,	PUNCT
bam-5830	692	84	italy	italy	PROPN
bam-5830	692	85	e	e	PROPN
bam-5830	692	86	-	-	NOUN
bam-5830	692	87	mail	mail	NOUN
bam-5830	692	88	:	:	PUNCT
bam-5830	692	89	andrea.cipriano@uniroma1.it	andrea.cipriano@uniroma1.it	X
bam-5830	692	90	the	the	DET
bam-5830	692	91	central	central	ADJ
bam-5830	692	92	dogma	dogma	NOUN
bam-5830	692	93	of	of	ADP
bam-5830	692	94	gene	gene	NOUN
bam-5830	692	95	expression	expression	NOUN
bam-5830	692	96	is	be	AUX
bam-5830	692	97	that	that	SCONJ
bam-5830	692	98	dna	dna	PROPN
bam-5830	692	99	is	be	AUX
bam-5830	692	100	transcribed	transcribe	VERB
bam-5830	692	101	into	into	ADP
bam-5830	692	102	messenger	messenger	NOUN
bam-5830	692	103	rnas	rna	NOUN
bam-5830	692	104	,	,	PUNCT
bam-5830	692	105	which	which	PRON
bam-5830	692	106	in	in	ADP
bam-5830	692	107	turn	turn	NOUN
bam-5830	692	108	serve	serve	VERB
bam-5830	692	109	as	as	ADP
bam-5830	692	110	the	the	DET
bam-5830	692	111	template	template	NOUN
bam-5830	692	112	for	for	ADP
bam-5830	692	113	protein	protein	NOUN
bam-5830	692	114	synthesis	synthesis	NOUN
bam-5830	692	115	.	.	PUNCT
bam-5830	693	1	in	in	ADP
bam-5830	693	2	recent	recent	ADJ
bam-5830	693	3	years	year	NOUN
bam-5830	693	4	,	,	PUNCT
bam-5830	693	5	it	it	PRON
bam-5830	693	6	has	have	AUX
bam-5830	693	7	been	be	AUX
bam-5830	693	8	discovered	discover	VERB
bam-5830	693	9	that	that	SCONJ
bam-5830	693	10	genomes	genome	NOUN
bam-5830	693	11	of	of	ADP
bam-5830	693	12	multicellular	multicellular	ADJ
bam-5830	693	13	organisms	organism	NOUN
bam-5830	693	14	are	be	AUX
bam-5830	693	15	characterized	characterize	VERB
bam-5830	693	16	by	by	ADP
bam-5830	693	17	the	the	DET
bam-5830	693	18	pervasive	pervasive	ADJ
bam-5830	693	19	expression	expression	NOUN
bam-5830	693	20	of	of	ADP
bam-5830	693	21	different	different	ADJ
bam-5830	693	22	types	type	NOUN
bam-5830	693	23	of	of	ADP
bam-5830	693	24	non	non	ADJ
bam-5830	693	25	-	-	ADJ
bam-5830	693	26	coding	coding	ADJ
bam-5830	693	27	rnas	rna	NOUN
bam-5830	693	28	(	(	PUNCT
bam-5830	693	29	ncrna	ncrna	NOUN
bam-5830	693	30	)	)	PUNCT
bam-5830	693	31	and	and	CCONJ
bam-5830	693	32	,	,	PUNCT
bam-5830	693	33	among	among	ADP
bam-5830	693	34	them	they	PRON
bam-5830	693	35	,	,	PUNCT
bam-5830	693	36	long	long	ADV
bam-5830	693	37	noncoding	noncoding	ADJ
bam-5830	693	38	rnas	rna	NOUN
bam-5830	693	39	(	(	PUNCT
bam-5830	693	40	incrnas	incrna	NOUN
bam-5830	693	41	)	)	PUNCT
bam-5830	693	42	.	.	PUNCT
bam-5830	694	1	in	in	ADP
bam-5830	694	2	particular	particular	ADJ
bam-5830	694	3	the	the	DET
bam-5830	694	4	mammalian	mammalian	ADJ
bam-5830	694	5	genome	genome	NOUN
bam-5830	694	6	contains	contain	VERB
bam-5830	694	7	many	many	ADJ
bam-5830	694	8	thousands	thousand	NOUN
bam-5830	694	9	of	of	ADP
bam-5830	694	10	lncrnas	lncrna	NOUN
bam-5830	694	11	,	,	PUNCT
bam-5830	694	12	which	which	PRON
bam-5830	694	13	have	have	AUX
bam-5830	694	14	been	be	AUX
bam-5830	694	15	proposed	propose	VERB
bam-5830	694	16	to	to	PART
bam-5830	694	17	be	be	AUX
bam-5830	694	18	fundamental	fundamental	ADJ
bam-5830	694	19	in	in	ADP
bam-5830	694	20	the	the	DET
bam-5830	694	21	regulation	regulation	NOUN
bam-5830	694	22	of	of	ADP
bam-5830	694	23	many	many	ADJ
bam-5830	694	24	biological	biological	ADJ
bam-5830	694	25	processes	process	NOUN
bam-5830	694	26	such	such	ADJ
bam-5830	694	27	as	as	ADP
bam-5830	694	28	cellular	cellular	ADJ
bam-5830	694	29	differentiation	differentiation	NOUN
bam-5830	694	30	and	and	CCONJ
bam-5830	694	31	show	show	VERB
bam-5830	694	32	an	an	DET
bam-5830	694	33	aberrant	aberrant	ADJ
bam-5830	694	34	regulation	regulation	NOUN
bam-5830	694	35	in	in	ADP
bam-5830	694	36	a	a	DET
bam-5830	694	37	variety	variety	NOUN
bam-5830	694	38	of	of	ADP
bam-5830	694	39	diseases	disease	NOUN
bam-5830	694	40	.	.	PUNCT
bam-5830	695	1	a	a	DET
bam-5830	695	2	transcriptome	transcriptome	ADJ
bam-5830	695	3	analysis	analysis	NOUN
bam-5830	695	4	performed	perform	VERB
bam-5830	695	5	during	during	ADP
bam-5830	695	6	in	in	ADP
bam-5830	695	7	vitro	vitro	X
bam-5830	695	8	murine	murine	ADJ
bam-5830	695	9	muscle	muscle	NOUN
bam-5830	695	10	differentiation	differentiation	NOUN
bam-5830	695	11	allowed	allow	VERB
bam-5830	695	12	us	we	PRON
bam-5830	695	13	to	to	PART
bam-5830	695	14	identify	identify	VERB
bam-5830	695	15	a	a	DET
bam-5830	695	16	subset	subset	NOUN
bam-5830	695	17	of	of	ADP
bam-5830	695	18	new	new	ADJ
bam-5830	695	19	lncrnas	lncrna	NOUN
bam-5830	695	20	differentially	differentially	ADV
bam-5830	695	21	expressed	express	VERB
bam-5830	695	22	during	during	ADP
bam-5830	695	23	myogenesis	myogenesis	NOUN
bam-5830	695	24	(	(	PUNCT
bam-5830	695	25	1	1	NUM
bam-5830	695	26	)	)	PUNCT
bam-5830	695	27	.	.	PUNCT
bam-5830	696	1	these	these	DET
bam-5830	696	2	transcripts	transcript	NOUN
bam-5830	696	3	were	be	AUX
bam-5830	696	4	classified	classify	VERB
bam-5830	696	5	on	on	ADP
bam-5830	696	6	the	the	DET
bam-5830	696	7	basis	basis	NOUN
bam-5830	696	8	of	of	ADP
bam-5830	696	9	their	their	PRON
bam-5830	696	10	expression	expression	NOUN
bam-5830	696	11	in	in	ADP
bam-5830	696	12	proliferating	proliferate	VERB
bam-5830	696	13	versus	versus	ADP
bam-5830	696	14	differentiated	differentiated	ADJ
bam-5830	696	15	conditions	condition	NOUN
bam-5830	696	16	,	,	PUNCT
bam-5830	696	17	muscle	muscle	NOUN
bam-5830	696	18	-	-	PUNCT
bam-5830	696	19	restricted	restrict	VERB
bam-5830	696	20	activation	activation	NOUN
bam-5830	696	21	and	and	CCONJ
bam-5830	696	22	subcellular	subcellular	ADJ
bam-5830	696	23	localization	localization	NOUN
bam-5830	696	24	.	.	PUNCT
bam-5830	697	1	we	we	PRON
bam-5830	697	2	are	be	AUX
bam-5830	697	3	now	now	ADV
bam-5830	697	4	focusing	focus	VERB
bam-5830	697	5	on	on	ADP
bam-5830	697	6	the	the	DET
bam-5830	697	7	characterization	characterization	NOUN
bam-5830	697	8	of	of	ADP
bam-5830	697	9	a	a	DET
bam-5830	697	10	nuclear	nuclear	ADJ
bam-5830	697	11	lncrna	lncrna	NOUN
bam-5830	697	12	conserved	conserve	VERB
bam-5830	697	13	in	in	ADP
bam-5830	697	14	human	human	ADJ
bam-5830	697	15	,	,	PUNCT
bam-5830	697	16	lnc-405	lnc-405	NOUN
bam-5830	697	17	,	,	PUNCT
bam-5830	697	18	up	up	ADV
bam-5830	697	19	-	-	PUNCT
bam-5830	697	20	regulated	regulate	VERB
bam-5830	697	21	during	during	ADP
bam-5830	697	22	abstracts	abstract	NOUN
bam-5830	697	23	of	of	ADP
bam-5830	697	24	the	the	DET
bam-5830	697	25	xii	xii	PROPN
bam-5830	697	26	iim	iim	NOUN
bam-5830	697	27	myology	myology	NOUN
bam-5830	697	28	meeting	meeting	NOUN
bam-5830	697	29	october	october	PROPN
bam-5830	697	30	1–4	1–4	PROPN
bam-5830	697	31	,	,	PUNCT
bam-5830	697	32	2015	2015	NUM
bam-5830	697	33	eur	eur	PROPN
bam-5830	697	34	j	j	PROPN
bam-5830	697	35	transl	transl	PROPN
bam-5830	697	36	myol	myol	PROPN
bam-5830	697	37	basic	basic	ADJ
bam-5830	697	38	appl	appl	NOUN
bam-5830	697	39	myol	myol	NOUN
bam-5830	697	40	2016	2016	NUM
bam-5830	697	41	;	;	PUNCT
bam-5830	697	42	26	26	NUM
bam-5830	697	43	(	(	PUNCT
bam-5830	697	44	1):2	1):2	NUM
bam-5830	697	45	-	-	SYM
bam-5830	697	46	24	24	NUM
bam-5830	697	47	this	this	DET
bam-5830	697	48	article	article	NOUN
bam-5830	697	49	is	be	AUX
bam-5830	697	50	distributed	distribute	VERB
bam-5830	697	51	under	under	ADP
bam-5830	697	52	the	the	DET
bam-5830	697	53	terms	term	NOUN
bam-5830	697	54	of	of	ADP
bam-5830	697	55	the	the	DET
bam-5830	697	56	creative	creative	ADJ
bam-5830	697	57	commons	common	NOUN
bam-5830	697	58	attribution	attribution	NOUN
bam-5830	697	59	noncommercial	noncommercial	ADJ
bam-5830	697	60	license	license	NOUN
bam-5830	697	61	(	(	PUNCT
bam-5830	697	62	cc	cc	NOUN
bam-5830	697	63	by	by	ADP
bam-5830	697	64	-	-	PUNCT
bam-5830	697	65	nc	nc	PROPN
bam-5830	697	66	4.0	4.0	NUM
bam-5830	697	67	)	)	PUNCT
bam-5830	697	68	which	which	PRON
bam-5830	697	69	permits	permit	VERB
bam-5830	697	70	any	any	DET
bam-5830	697	71	noncommercial	noncommercial	ADJ
bam-5830	697	72	use	use	NOUN
bam-5830	697	73	,	,	PUNCT
bam-5830	697	74	distribution	distribution	NOUN
bam-5830	697	75	,	,	PUNCT
bam-5830	697	76	and	and	CCONJ
bam-5830	697	77	reproduction	reproduction	NOUN
bam-5830	697	78	in	in	ADP
bam-5830	697	79	any	any	DET
bam-5830	697	80	medium	medium	NOUN
bam-5830	697	81	,	,	PUNCT
bam-5830	697	82	provided	provide	VERB
bam-5830	697	83	the	the	DET
bam-5830	697	84	original	original	ADJ
bam-5830	697	85	author(s	author(s	NOUN
bam-5830	697	86	)	)	PUNCT
bam-5830	697	87	and	and	CCONJ
bam-5830	697	88	source	source	NOUN
bam-5830	697	89	are	be	AUX
bam-5830	697	90	credited	credit	VERB
bam-5830	697	91	.	.	PUNCT
bam-5830	698	1	21	21	NUM
bam-5830	698	2	differentiation	differentiation	NOUN
bam-5830	698	3	,	,	PUNCT
bam-5830	698	4	whose	whose	DET
bam-5830	698	5	expression	expression	NOUN
bam-5830	698	6	is	be	AUX
bam-5830	698	7	cardiac	cardiac	ADJ
bam-5830	698	8	and	and	CCONJ
bam-5830	698	9	skeletal	skeletal	ADJ
bam-5830	698	10	muscle	muscle	NOUN
bam-5830	698	11	restricted	restrict	VERB
bam-5830	698	12	.	.	PUNCT
bam-5830	699	1	to	to	PART
bam-5830	699	2	dissect	dissect	VERB
bam-5830	699	3	its	its	PRON
bam-5830	699	4	role	role	NOUN
bam-5830	699	5	in	in	ADP
bam-5830	699	6	myogenesis	myogenesis	NOUN
bam-5830	699	7	,	,	PUNCT
bam-5830	699	8	we	we	PRON
bam-5830	699	9	performed	perform	VERB
bam-5830	699	10	loss	loss	NOUN
bam-5830	699	11	of	of	ADP
bam-5830	699	12	function	function	NOUN
bam-5830	699	13	experiments	experiment	NOUN
bam-5830	699	14	using	use	VERB
bam-5830	699	15	lna	lna	PROPN
bam-5830	699	16	-	-	PUNCT
bam-5830	699	17	gapmers	gapmer	NOUN
bam-5830	699	18	followed	follow	VERB
bam-5830	699	19	by	by	ADP
bam-5830	699	20	a	a	DET
bam-5830	699	21	transcriptome	transcriptome	ADJ
bam-5830	699	22	analysis	analysis	NOUN
bam-5830	699	23	.	.	PUNCT
bam-5830	700	1	this	this	DET
bam-5830	700	2	approach	approach	NOUN
bam-5830	700	3	revealed	reveal	VERB
bam-5830	700	4	a	a	DET
bam-5830	700	5	strong	strong	ADJ
bam-5830	700	6	down	down	NOUN
bam-5830	700	7	-	-	PUNCT
bam-5830	700	8	regulation	regulation	NOUN
bam-5830	700	9	of	of	ADP
bam-5830	700	10	a	a	DET
bam-5830	700	11	subset	subset	NOUN
bam-5830	700	12	of	of	ADP
bam-5830	700	13	genes	gene	NOUN
bam-5830	700	14	involved	involve	VERB
bam-5830	700	15	in	in	ADP
bam-5830	700	16	fiber	fiber	NOUN
bam-5830	700	17	contraction	contraction	NOUN
bam-5830	700	18	,	,	PUNCT
bam-5830	700	19	cell	cell	NOUN
bam-5830	700	20	fusion	fusion	NOUN
bam-5830	700	21	and	and	CCONJ
bam-5830	700	22	related	relate	VERB
bam-5830	700	23	to	to	ADP
bam-5830	700	24	several	several	ADJ
bam-5830	700	25	cardiomyopathies	cardiomyopathy	NOUN
bam-5830	700	26	.	.	PUNCT
bam-5830	701	1	with	with	ADP
bam-5830	701	2	the	the	DET
bam-5830	701	3	idea	idea	NOUN
bam-5830	701	4	to	to	PART
bam-5830	701	5	better	well	ADV
bam-5830	701	6	explain	explain	VERB
bam-5830	701	7	its	its	PRON
bam-5830	701	8	crucial	crucial	ADJ
bam-5830	701	9	role	role	NOUN
bam-5830	701	10	during	during	ADP
bam-5830	701	11	myogenesis	myogenesis	NOUN
bam-5830	701	12	,	,	PUNCT
bam-5830	701	13	we	we	PRON
bam-5830	701	14	are	be	AUX
bam-5830	701	15	now	now	ADV
bam-5830	701	16	focusing	focus	VERB
bam-5830	701	17	on	on	ADP
bam-5830	701	18	the	the	DET
bam-5830	701	19	molecular	molecular	ADJ
bam-5830	701	20	mechanism	mechanism	NOUN
bam-5830	701	21	by	by	ADP
bam-5830	701	22	which	which	PRON
bam-5830	701	23	lnc-405	lnc-405	NOUN
bam-5830	701	24	exerts	exert	VERB
bam-5830	701	25	its	its	PRON
bam-5830	701	26	function	function	NOUN
bam-5830	701	27	in	in	ADP
bam-5830	701	28	the	the	DET
bam-5830	701	29	nucleus	nucleus	NOUN
bam-5830	701	30	by	by	ADP
bam-5830	701	31	rip	rip	NOUN
bam-5830	701	32	,	,	PUNCT
bam-5830	701	33	chirp	chirp	ADJ
bam-5830	701	34	and	and	CCONJ
bam-5830	701	35	rna	rna	NOUN
bam-5830	701	36	pull	pull	NOUN
bam-5830	701	37	-	-	PUNCT
bam-5830	701	38	down	down	NOUN
bam-5830	701	39	assays	assay	NOUN
bam-5830	701	40	that	that	PRON
bam-5830	701	41	are	be	AUX
bam-5830	701	42	on	on	ADP
bam-5830	701	43	going	go	VERB
bam-5830	701	44	.	.	PUNCT
bam-5830	702	1	1	1	X
bam-5830	702	2	.	.	X
bam-5830	702	3	ballarino	ballarino	PROPN
bam-5830	702	4	m	m	PROPN
bam-5830	702	5	,	,	PUNCT
bam-5830	702	6	et	et	PROPN
bam-5830	702	7	al	al	PROPN
bam-5830	702	8	.	.	PROPN
bam-5830	702	9	mcb	mcb	PROPN
bam-5830	702	10	,	,	PUNCT
bam-5830	702	11	2015	2015	NUM
bam-5830	702	12	.	.	PUNCT
bam-5830	703	1	*	*	PUNCT
bam-5830	703	2	*	*	PUNCT
bam-5830	703	3	*	*	PUNCT
bam-5830	703	4	*	*	PUNCT
bam-5830	703	5	*	*	ADJ
bam-5830	703	6	muscle	muscle	NOUN
bam-5830	703	7	expression	expression	NOUN
bam-5830	703	8	of	of	ADP
bam-5830	703	9	sod1g93a	sod1g93a	NUM
bam-5830	703	10	modulates	modulate	NOUN
bam-5830	703	11	microrna	microrna	PROPN
bam-5830	703	12	and	and	CCONJ
bam-5830	703	13	mrna	mrna	PROPN
bam-5830	703	14	expression	expression	NOUN
bam-5830	703	15	pattern	pattern	NOUN
bam-5830	703	16	in	in	ADP
bam-5830	703	17	the	the	DET
bam-5830	703	18	spinal	spinal	ADJ
bam-5830	703	19	cord	cord	NOUN
bam-5830	703	20	of	of	ADP
bam-5830	703	21	transgenic	transgenic	NOUN
bam-5830	703	22	mice	mouse	NOUN
bam-5830	703	23	m.	m.	NOUN
bam-5830	703	24	martini	martini	PROPN
bam-5830	703	25	1,2	1,2	NUM
bam-5830	703	26	,	,	PUNCT
bam-5830	703	27	g.	g.	PROPN
bam-5830	703	28	dobrowolny	dobrowolny	PROPN
bam-5830	703	29	1,2	1,2	NUM
bam-5830	703	30	,	,	PUNCT
bam-5830	703	31	a.	a.	NOUN
bam-5830	703	32	musarò	musarò	NOUN
bam-5830	703	33	1,2	1,2	NUM
bam-5830	703	34	1	1	NUM
bam-5830	703	35	institute	institute	NOUN
bam-5830	703	36	pasteur	pasteur	PROPN
bam-5830	703	37	-	-	PUNCT
bam-5830	703	38	cenci	cenci	PROPN
bam-5830	703	39	bolognetti	bolognetti	NOUN
bam-5830	703	40	,	,	PUNCT
bam-5830	703	41	dahfmo	dahfmo	NOUN
bam-5830	703	42	-	-	PUNCT
bam-5830	703	43	unit	unit	NOUN
bam-5830	703	44	of	of	ADP
bam-5830	703	45	histology	histology	NOUN
bam-5830	703	46	and	and	CCONJ
bam-5830	703	47	medical	medical	ADJ
bam-5830	703	48	embryology	embryology	NOUN
bam-5830	703	49	,	,	PUNCT
bam-5830	703	50	iim	iim	PROPN
bam-5830	703	51	,	,	PUNCT
bam-5830	703	52	sapienza	sapienza	PROPN
bam-5830	703	53	university	university	PROPN
bam-5830	703	54	of	of	ADP
bam-5830	703	55	rome	rome	PROPN
bam-5830	703	56	,	,	PUNCT
bam-5830	703	57	italy	italy	PROPN
bam-5830	703	58	;	;	PUNCT
bam-5830	703	59	2	2	X
bam-5830	703	60	.	.	X
bam-5830	703	61	center	center	NOUN
bam-5830	703	62	for	for	ADP
bam-5830	703	63	life	life	NOUN
bam-5830	703	64	nano	nano	NOUN
bam-5830	703	65	science	science	NOUN
bam-5830	703	66	at	at	ADP
bam-5830	703	67	sapienza	sapienza	PROPN
bam-5830	703	68	,	,	PUNCT
bam-5830	703	69	istituto	istituto	X
bam-5830	703	70	italiano	italiano	NOUN
bam-5830	703	71	di	di	X
bam-5830	703	72	tecnologia	tecnologia	PROPN
bam-5830	703	73	,	,	PUNCT
bam-5830	703	74	rome	rome	PROPN
bam-5830	703	75	,	,	PUNCT
bam-5830	703	76	italy	italy	PROPN
bam-5830	703	77	e	e	PROPN
bam-5830	703	78	-	-	NOUN
bam-5830	703	79	mail	mail	NOUN
bam-5830	703	80	:	:	PUNCT
bam-5830	703	81	martina.martini@uniroma1.it	martina.martini@uniroma1.it	NOUN
bam-5830	703	82	the	the	DET
bam-5830	703	83	functional	functional	ADJ
bam-5830	703	84	connection	connection	NOUN
bam-5830	703	85	between	between	ADP
bam-5830	703	86	muscle	muscle	NOUN
bam-5830	703	87	and	and	CCONJ
bam-5830	703	88	nerve	nerve	NOUN
bam-5830	703	89	is	be	AUX
bam-5830	703	90	affected	affect	VERB
bam-5830	703	91	in	in	ADP
bam-5830	703	92	several	several	ADJ
bam-5830	703	93	neuromuscular	neuromuscular	ADJ
bam-5830	703	94	diseases	disease	NOUN
bam-5830	703	95	,	,	PUNCT
bam-5830	703	96	including	include	VERB
bam-5830	703	97	amyotrophic	amyotrophic	ADJ
bam-5830	703	98	lateral	lateral	ADJ
bam-5830	703	99	sclerosis	sclerosis	NOUN
bam-5830	703	100	(	(	PUNCT
bam-5830	703	101	als	als	NOUN
bam-5830	703	102	)	)	PUNCT
bam-5830	703	103	whose	whose	DET
bam-5830	703	104	major	major	ADJ
bam-5830	703	105	pathological	pathological	ADJ
bam-5830	703	106	processes	process	NOUN
bam-5830	703	107	are	be	AUX
bam-5830	703	108	motor	motor	NOUN
bam-5830	703	109	neuron	neuron	NOUN
bam-5830	703	110	degeneration	degeneration	NOUN
bam-5830	703	111	.	.	PUNCT
bam-5830	704	1	however	however	ADV
bam-5830	704	2	,	,	PUNCT
bam-5830	704	3	other	other	ADJ
bam-5830	704	4	cells	cell	NOUN
bam-5830	704	5	may	may	AUX
bam-5830	704	6	be	be	AUX
bam-5830	704	7	involved	involve	VERB
bam-5830	704	8	in	in	ADP
bam-5830	704	9	the	the	DET
bam-5830	704	10	pathogenesis	pathogenesis	NOUN
bam-5830	704	11	of	of	ADP
bam-5830	704	12	als	al	NOUN
bam-5830	704	13	and	and	CCONJ
bam-5830	704	14	open	open	VERB
bam-5830	704	15	the	the	DET
bam-5830	704	16	possibility	possibility	NOUN
bam-5830	704	17	that	that	PRON
bam-5830	704	18	alteration	alteration	NOUN
bam-5830	704	19	in	in	ADP
bam-5830	704	20	skeletal	skeletal	ADJ
bam-5830	704	21	muscle	muscle	NOUN
bam-5830	704	22	homeostasis	homeostasis	NOUN
bam-5830	704	23	represents	represent	VERB
bam-5830	704	24	one	one	NUM
bam-5830	704	25	of	of	ADP
bam-5830	704	26	the	the	DET
bam-5830	704	27	principal	principal	ADJ
bam-5830	704	28	mediators	mediator	NOUN
bam-5830	704	29	of	of	ADP
bam-5830	704	30	motor	motor	NOUN
bam-5830	704	31	neuron	neuron	PROPN
bam-5830	704	32	degeneration	degeneration	NOUN
bam-5830	704	33	.	.	PUNCT
bam-5830	705	1	we	we	PRON
bam-5830	705	2	have	have	VERB
bam-5830	705	3	evidences	evidence	NOUN
bam-5830	705	4	that	that	PRON
bam-5830	705	5	indicate	indicate	VERB
bam-5830	705	6	that	that	DET
bam-5830	705	7	muscle	muscle	NOUN
bam-5830	705	8	selective	selective	ADJ
bam-5830	705	9	expression	expression	NOUN
bam-5830	705	10	of	of	ADP
bam-5830	705	11	sod1g93a	sod1g93a	CCONJ
bam-5830	705	12	mutant	mutant	ADJ
bam-5830	705	13	gene	gene	NOUN
bam-5830	705	14	modulates	modulate	NOUN
bam-5830	705	15	,	,	PUNCT
bam-5830	705	16	at	at	ADP
bam-5830	705	17	the	the	DET
bam-5830	705	18	level	level	NOUN
bam-5830	705	19	of	of	ADP
bam-5830	705	20	spinal	spinal	ADJ
bam-5830	705	21	cord	cord	NOUN
bam-5830	705	22	of	of	ADP
bam-5830	705	23	mlc	mlc	PROPN
bam-5830	705	24	/	/	SYM
bam-5830	705	25	sod1g93a	sod1g93a	NUM
bam-5830	705	26	mice	mouse	NOUN
bam-5830	705	27	,	,	PUNCT
bam-5830	705	28	relevant	relevant	ADJ
bam-5830	705	29	mrna	mrna	PROPN
bam-5830	705	30	and	and	CCONJ
bam-5830	705	31	microrna	microrna	PROPN
bam-5830	705	32	associated	associate	VERB
bam-5830	705	33	with	with	ADP
bam-5830	705	34	myelin	myelin	NOUN
bam-5830	705	35	homeostasis	homeostasis	NOUN
bam-5830	705	36	.	.	PUNCT
bam-5830	706	1	our	our	PRON
bam-5830	706	2	study	study	NOUN
bam-5830	706	3	provided	provide	VERB
bam-5830	706	4	insights	insight	NOUN
bam-5830	706	5	into	into	ADP
bam-5830	706	6	the	the	DET
bam-5830	706	7	pathophysiological	pathophysiological	ADJ
bam-5830	706	8	interplay	interplay	NOUN
bam-5830	706	9	between	between	ADP
bam-5830	706	10	muscle	muscle	NOUN
bam-5830	706	11	and	and	CCONJ
bam-5830	706	12	nerve	nerve	NOUN
bam-5830	706	13	and	and	CCONJ
bam-5830	706	14	supports	support	VERB
bam-5830	706	15	the	the	DET
bam-5830	706	16	hypothesis	hypothesis	NOUN
bam-5830	706	17	that	that	PRON
bam-5830	706	18	skeletal	skeletal	ADJ
bam-5830	706	19	muscle	muscle	NOUN
bam-5830	706	20	is	be	AUX
bam-5830	706	21	a	a	DET
bam-5830	706	22	source	source	NOUN
bam-5830	706	23	of	of	ADP
bam-5830	706	24	signals	signal	NOUN
bam-5830	706	25	that	that	PRON
bam-5830	706	26	can	can	AUX
bam-5830	706	27	affect	affect	VERB
bam-5830	706	28	the	the	DET
bam-5830	706	29	nervous	nervous	ADJ
bam-5830	706	30	system	system	NOUN
bam-5830	706	31	.	.	PUNCT
bam-5830	707	1	*	*	PUNCT
bam-5830	707	2	*	*	PUNCT
bam-5830	707	3	*	*	PUNCT
bam-5830	707	4	*	*	PUNCT
bam-5830	707	5	*	*	PUNCT
bam-5830	707	6	characterization	characterization	NOUN
bam-5830	707	7	of	of	ADP
bam-5830	707	8	a	a	DET
bam-5830	707	9	calsequestrin-1	calsequestrin-1	PROPN
bam-5830	707	10	mutation	mutation	NOUN
bam-5830	707	11	identified	identify	VERB
bam-5830	707	12	in	in	ADP
bam-5830	707	13	patients	patient	NOUN
bam-5830	707	14	affected	affect	VERB
bam-5830	707	15	by	by	ADP
bam-5830	707	16	a	a	DET
bam-5830	707	17	vacuolar	vacuolar	ADJ
bam-5830	707	18	myophaty	myophaty	NOUN
bam-5830	707	19	v.	v.	ADP
bam-5830	707	20	del	del	PROPN
bam-5830	707	21	re	re	PROPN
bam-5830	707	22	,	,	PUNCT
bam-5830	707	23	s.	s.	PROPN
bam-5830	707	24	spinozzi	spinozzi	PROPN
bam-5830	707	25	,	,	PUNCT
bam-5830	707	26	a.	a.	NOUN
bam-5830	707	27	gamberucci	gamberucci	NOUN
bam-5830	707	28	,	,	PUNCT
bam-5830	707	29	v.	v.	X
bam-5830	707	30	barone	barone	PROPN
bam-5830	707	31	,	,	PUNCT
bam-5830	707	32	v.	v.	ADP
bam-5830	707	33	sorrentino1	sorrentino1	PROPN
bam-5830	707	34	.	.	PUNCT
bam-5830	708	1	section	section	NOUN
bam-5830	708	2	of	of	ADP
bam-5830	708	3	molecular	molecular	ADJ
bam-5830	708	4	medicine	medicine	NOUN
bam-5830	708	5	,	,	PUNCT
bam-5830	708	6	department	department	NOUN
bam-5830	708	7	of	of	ADP
bam-5830	708	8	molecular	molecular	ADJ
bam-5830	708	9	and	and	CCONJ
bam-5830	708	10	developmental	developmental	ADJ
bam-5830	708	11	medicine	medicine	NOUN
bam-5830	708	12	,	,	PUNCT
bam-5830	708	13	university	university	PROPN
bam-5830	708	14	of	of	ADP
bam-5830	708	15	siena	siena	PROPN
bam-5830	708	16	,	,	PUNCT
bam-5830	708	17	italy	italy	PROPN
bam-5830	708	18	e	e	PROPN
bam-5830	708	19	-	-	NOUN
bam-5830	708	20	mail	mail	NOUN
bam-5830	708	21	:	:	PUNCT
bam-5830	708	22	valeriadelre@libero.it	valeriadelre@libero.it	PROPN
bam-5830	708	23	calsequestrin	calsequestrin	PROPN
bam-5830	708	24	(	(	PUNCT
bam-5830	708	25	casq	casq	PROPN
bam-5830	708	26	)	)	PUNCT
bam-5830	708	27	is	be	AUX
bam-5830	708	28	the	the	DET
bam-5830	708	29	major	major	ADJ
bam-5830	708	30	protein	protein	NOUN
bam-5830	708	31	of	of	ADP
bam-5830	708	32	the	the	DET
bam-5830	708	33	sarcoplasmic	sarcoplasmic	ADJ
bam-5830	708	34	reticulum	reticulum	NOUN
bam-5830	708	35	of	of	ADP
bam-5830	708	36	striated	striated	ADJ
bam-5830	708	37	muscle	muscle	NOUN
bam-5830	708	38	that	that	PRON
bam-5830	708	39	binds	bind	VERB
bam-5830	708	40	ca2	ca2	PROPN
bam-5830	708	41	+	+	PROPN
bam-5830	708	42	with	with	ADP
bam-5830	708	43	high	high	ADJ
bam-5830	708	44	capacity	capacity	NOUN
bam-5830	708	45	and	and	CCONJ
bam-5830	708	46	moderate	moderate	ADJ
bam-5830	708	47	affinity	affinity	NOUN
bam-5830	708	48	.	.	PUNCT
bam-5830	709	1	casq	casq	PROPN
bam-5830	709	2	exist	exist	VERB
bam-5830	709	3	as	as	ADP
bam-5830	709	4	a	a	DET
bam-5830	709	5	monomer	monomer	NOUN
bam-5830	709	6	and	and	CCONJ
bam-5830	709	7	polymers	polymer	NOUN
bam-5830	709	8	,	,	PUNCT
bam-5830	709	9	depending	depend	VERB
bam-5830	709	10	on	on	ADP
bam-5830	709	11	ca2	ca2	PROPN
bam-5830	709	12	+	+	PROPN
bam-5830	709	13	concentration	concentration	NOUN
bam-5830	709	14	.	.	PUNCT
bam-5830	710	1	casq	casq	PROPN
bam-5830	710	2	switches	switch	NOUN
bam-5830	710	3	from	from	ADP
bam-5830	710	4	an	an	DET
bam-5830	710	5	unfolded	unfolded	ADJ
bam-5830	710	6	state	state	NOUN
bam-5830	710	7	to	to	ADP
bam-5830	710	8	a	a	DET
bam-5830	710	9	folded	fold	VERB
bam-5830	710	10	monomer	monomer	NOUN
bam-5830	710	11	when	when	SCONJ
bam-5830	710	12	the	the	DET
bam-5830	710	13	ionic	ionic	ADJ
bam-5830	710	14	strength	strength	NOUN
bam-5830	710	15	increases	increase	VERB
bam-5830	710	16	allowing	allow	VERB
bam-5830	710	17	the	the	DET
bam-5830	710	18	formation	formation	NOUN
bam-5830	710	19	of	of	ADP
bam-5830	710	20	front	front	NOUN
bam-5830	710	21	-	-	PUNCT
bam-5830	710	22	to	to	ADP
bam-5830	710	23	-	-	PUNCT
bam-5830	710	24	front	front	NOUN
bam-5830	710	25	first	first	ADV
bam-5830	710	26	and	and	CCONJ
bam-5830	710	27	then	then	ADV
bam-5830	710	28	back	back	NOUN
bam-5830	710	29	-	-	PUNCT
bam-5830	710	30	to	to	ADP
bam-5830	710	31	-	-	PUNCT
bam-5830	710	32	back	back	NOUN
bam-5830	710	33	interactions	interaction	NOUN
bam-5830	710	34	in	in	ADP
bam-5830	710	35	higher	high	ADJ
bam-5830	710	36	ca2	ca2	PROPN
bam-5830	710	37	+	+	PROPN
bam-5830	710	38	concentrations	concentration	NOUN
bam-5830	710	39	.	.	PUNCT
bam-5830	711	1	in	in	ADP
bam-5830	711	2	humans	human	NOUN
bam-5830	711	3	,	,	PUNCT
bam-5830	711	4	mutations	mutation	NOUN
bam-5830	711	5	in	in	ADP
bam-5830	711	6	the	the	DET
bam-5830	711	7	cardiac	cardiac	ADJ
bam-5830	711	8	isoform	isoform	NOUN
bam-5830	711	9	casq2	casq2	NOUN
bam-5830	711	10	lead	lead	VERB
bam-5830	711	11	to	to	ADP
bam-5830	711	12	catecholamine	catecholamine	NOUN
bam-5830	711	13	-	-	PUNCT
bam-5830	711	14	induced	induce	VERB
bam-5830	711	15	polymorphic	polymorphic	ADJ
bam-5830	711	16	ventricular	ventricular	ADJ
bam-5830	711	17	tachycardia	tachycardia	NOUN
bam-5830	711	18	.	.	PUNCT
bam-5830	712	1	recently	recently	ADV
bam-5830	712	2	we	we	PRON
bam-5830	712	3	reported	report	VERB
bam-5830	712	4	one	one	NUM
bam-5830	712	5	mutation	mutation	NOUN
bam-5830	712	6	in	in	ADP
bam-5830	712	7	the	the	DET
bam-5830	712	8	skeletal	skeletal	ADJ
bam-5830	712	9	casq1	casq1	NOUN
bam-5830	712	10	gene	gene	NOUN
bam-5830	712	11	in	in	ADP
bam-5830	712	12	a	a	DET
bam-5830	712	13	group	group	NOUN
bam-5830	712	14	of	of	ADP
bam-5830	712	15	patients	patient	NOUN
bam-5830	712	16	with	with	ADP
bam-5830	712	17	a	a	DET
bam-5830	712	18	vacuolar	vacuolar	ADJ
bam-5830	712	19	myopathy	myopathy	NOUN
bam-5830	712	20	characterized	characterize	VERB
bam-5830	712	21	by	by	ADP
bam-5830	712	22	the	the	DET
bam-5830	712	23	presence	presence	NOUN
bam-5830	712	24	of	of	ADP
bam-5830	712	25	inclusions	inclusion	NOUN
bam-5830	712	26	containing	contain	VERB
bam-5830	712	27	casq1	casq1	NOUN
bam-5830	712	28	and	and	CCONJ
bam-5830	712	29	other	other	ADJ
bam-5830	712	30	sr	sr	PROPN
bam-5830	712	31	proteins	protein	NOUN
bam-5830	712	32	.	.	PUNCT
bam-5830	713	1	the	the	DET
bam-5830	713	2	casq1	casq1	PROPN
bam-5830	713	3	mutation	mutation	NOUN
bam-5830	713	4	(	(	PUNCT
bam-5830	713	5	casq1d244	casq1d244	NOUN
bam-5830	713	6	g	g	NOUN
bam-5830	713	7	)	)	PUNCT
bam-5830	713	8	affects	affect	VERB
bam-5830	713	9	one	one	NUM
bam-5830	713	10	of	of	ADP
bam-5830	713	11	the	the	DET
bam-5830	713	12	high	high	ADJ
bam-5830	713	13	-	-	PUNCT
bam-5830	713	14	affinity	affinity	NOUN
bam-5830	713	15	ca2	ca2	PROPN
bam-5830	713	16	+	+	PROPN
bam-5830	713	17	-binding	-binde	VERB
bam-5830	713	18	sites	site	NOUN
bam-5830	713	19	of	of	ADP
bam-5830	713	20	the	the	DET
bam-5830	713	21	protein	protein	NOUN
bam-5830	713	22	and	and	CCONJ
bam-5830	713	23	alters	alter	VERB
bam-5830	713	24	the	the	DET
bam-5830	713	25	kinetics	kinetic	NOUN
bam-5830	713	26	of	of	ADP
bam-5830	713	27	ca2	ca2	PROPN
bam-5830	713	28	+	+	NOUN
bam-5830	713	29	release	release	NOUN
bam-5830	713	30	in	in	ADP
bam-5830	713	31	muscle	muscle	NOUN
bam-5830	713	32	fibers	fiber	NOUN
bam-5830	713	33	from	from	ADP
bam-5830	713	34	patients	patient	NOUN
bam-5830	713	35	.	.	PUNCT
bam-5830	714	1	expression	expression	NOUN
bam-5830	714	2	of	of	ADP
bam-5830	714	3	the	the	DET
bam-5830	714	4	casq1d244	casq1d244	NOUN
bam-5830	714	5	g	g	NOUN
bam-5830	714	6	in	in	ADP
bam-5830	714	7	myotubes	myotube	NOUN
bam-5830	714	8	and	and	CCONJ
bam-5830	714	9	in	in	ADP
bam-5830	714	10	mouse	mouse	NOUN
bam-5830	714	11	fibers	fiber	NOUN
bam-5830	714	12	causes	cause	VERB
bam-5830	714	13	the	the	DET
bam-5830	714	14	appearance	appearance	NOUN
bam-5830	714	15	of	of	ADP
bam-5830	714	16	sr	sr	PROPN
bam-5830	714	17	vacuoles	vacuole	NOUN
bam-5830	714	18	containing	contain	VERB
bam-5830	714	19	aggregates	aggregate	NOUN
bam-5830	714	20	of	of	ADP
bam-5830	714	21	the	the	DET
bam-5830	714	22	mutant	mutant	ADJ
bam-5830	714	23	casq1	casq1	NOUN
bam-5830	714	24	protein	protein	NOUN
bam-5830	714	25	that	that	PRON
bam-5830	714	26	resemble	resemble	VERB
bam-5830	714	27	those	those	PRON
bam-5830	714	28	observed	observe	VERB
bam-5830	714	29	in	in	ADP
bam-5830	714	30	patients	patient	NOUN
bam-5830	714	31	.	.	PUNCT
bam-5830	715	1	studies	study	NOUN
bam-5830	715	2	of	of	ADP
bam-5830	715	3	ca2	ca2	PROPN
bam-5830	715	4	+	+	NOUN
bam-5830	715	5	release	release	NOUN
bam-5830	715	6	showed	show	VERB
bam-5830	715	7	an	an	DET
bam-5830	715	8	increase	increase	NOUN
bam-5830	715	9	in	in	ADP
bam-5830	715	10	ca2	ca2	PROPN
bam-5830	715	11	+	+	PROPN
bam-5830	715	12	storage	storage	NOUN
bam-5830	715	13	in	in	ADP
bam-5830	715	14	casq1wt	casq1wt	NOUN
bam-5830	715	15	cos-7	cos-7	PUNCT
bam-5830	715	16	transfected	transfecte	VERB
bam-5830	715	17	cells	cell	NOUN
bam-5830	715	18	whereas	whereas	SCONJ
bam-5830	715	19	no	no	DET
bam-5830	715	20	increase	increase	NOUN
bam-5830	715	21	was	be	AUX
bam-5830	715	22	observed	observe	VERB
bam-5830	715	23	in	in	ADP
bam-5830	715	24	casq1d244	casq1d244	AUX
bam-5830	715	25	g.	g.	NOUN
bam-5830	715	26	moreover	moreover	ADV
bam-5830	715	27	both	both	DET
bam-5830	715	28	casq1wt	casq1wt	NOUN
bam-5830	715	29	and	and	CCONJ
bam-5830	715	30	casq1d244	casq1d244	NOUN
bam-5830	715	31	g	g	NOUN
bam-5830	715	32	were	be	AUX
bam-5830	715	33	expressed	express	VERB
bam-5830	715	34	in	in	ADP
bam-5830	715	35	bacteria	bacteria	NOUN
bam-5830	715	36	,	,	PUNCT
bam-5830	715	37	purified	purified	ADJ
bam-5830	715	38	and	and	CCONJ
bam-5830	715	39	analysed	analyse	VERB
bam-5830	715	40	for	for	ADP
bam-5830	715	41	their	their	PRON
bam-5830	715	42	ability	ability	NOUN
bam-5830	715	43	to	to	PART
bam-5830	715	44	polymerize	polymerize	VERB
bam-5830	715	45	at	at	ADP
bam-5830	715	46	increasing	increase	VERB
bam-5830	715	47	ca2	ca2	PROPN
bam-5830	715	48	+	+	PROPN
bam-5830	715	49	concentrations	concentration	NOUN
bam-5830	715	50	.	.	PUNCT
bam-5830	716	1	the	the	DET
bam-5830	716	2	results	result	NOUN
bam-5830	716	3	obtained	obtain	VERB
bam-5830	716	4	indicate	indicate	VERB
bam-5830	716	5	that	that	SCONJ
bam-5830	716	6	the	the	DET
bam-5830	716	7	casq1d244	casq1d244	NOUN
bam-5830	716	8	g	g	NOUN
bam-5830	716	9	protein	protein	NOUN
bam-5830	716	10	polymerizes	polymerize	VERB
bam-5830	716	11	at	at	ADP
bam-5830	716	12	lower	low	ADJ
bam-5830	716	13	ca2	ca2	PROPN
bam-5830	716	14	+	+	PROPN
bam-5830	716	15	levels	level	NOUN
bam-5830	716	16	and	and	CCONJ
bam-5830	716	17	more	more	ADV
bam-5830	716	18	rapidly	rapidly	ADV
bam-5830	716	19	than	than	ADP
bam-5830	716	20	casq1wt	casq1wt	NOUN
bam-5830	716	21	.	.	PUNCT
bam-5830	717	1	these	these	DET
bam-5830	717	2	results	result	NOUN
bam-5830	717	3	suggest	suggest	VERB
bam-5830	717	4	that	that	SCONJ
bam-5830	717	5	the	the	DET
bam-5830	717	6	casq1d244	casq1d244	NOUN
bam-5830	717	7	g	g	NOUN
bam-5830	717	8	mutation	mutation	NOUN
bam-5830	717	9	interferes	interfere	VERB
bam-5830	717	10	with	with	ADP
bam-5830	717	11	the	the	DET
bam-5830	717	12	correct	correct	ADJ
bam-5830	717	13	process	process	NOUN
bam-5830	717	14	of	of	ADP
bam-5830	717	15	ca2	ca2	PROPN
bam-5830	717	16	+	+	CCONJ
bam-5830	717	17	-dependent	-dependent	ADJ
bam-5830	717	18	protein	protein	NOUN
bam-5830	717	19	polymerization	polymerization	NOUN
bam-5830	717	20	causing	cause	VERB
bam-5830	717	21	altered	alter	VERB
bam-5830	717	22	intracellular	intracellular	ADJ
bam-5830	717	23	calcium	calcium	NOUN
bam-5830	717	24	storage	storage	NOUN
bam-5830	717	25	and	and	CCONJ
bam-5830	717	26	the	the	DET
bam-5830	717	27	formation	formation	NOUN
bam-5830	717	28	of	of	ADP
bam-5830	717	29	protein	protein	NOUN
bam-5830	717	30	aggregates	aggregate	NOUN
bam-5830	717	31	.	.	PUNCT
bam-5830	718	1	*	*	PUNCT
bam-5830	718	2	*	*	PUNCT
bam-5830	718	3	*	*	PUNCT
bam-5830	718	4	*	*	PUNCT
bam-5830	718	5	*	*	PUNCT
bam-5830	718	6	functional	functional	ADJ
bam-5830	718	7	cross	cross	NOUN
bam-5830	718	8	-	-	NOUN
bam-5830	718	9	talk	talk	NOUN
bam-5830	718	10	between	between	ADP
bam-5830	718	11	the	the	DET
bam-5830	718	12	different	different	ADJ
bam-5830	718	13	cell	cell	NOUN
bam-5830	718	14	populations	population	NOUN
bam-5830	718	15	that	that	PRON
bam-5830	718	16	contribute	contribute	VERB
bam-5830	718	17	to	to	ADP
bam-5830	718	18	dmd	dmd	NOUN
bam-5830	718	19	progression	progression	NOUN
bam-5830	718	20	m.	m.	NOUN
bam-5830	718	21	sandonà	sandonà	PROPN
bam-5830	718	22	1	1	NUM
bam-5830	718	23	,	,	PUNCT
bam-5830	718	24	v.	v.	ADP
bam-5830	718	25	saccone	saccone	NOUN
bam-5830	718	26	1	1	NUM
bam-5830	718	27	,	,	PUNCT
bam-5830	718	28	s.	s.	PROPN
bam-5830	718	29	consalvi	consalvi	PROPN
bam-5830	718	30	1	1	NUM
bam-5830	718	31	,	,	PUNCT
bam-5830	718	32	l.	l.	PROPN
bam-5830	718	33	tucciarone	tucciarone	PROPN
bam-5830	718	34	1	1	NUM
bam-5830	718	35	,	,	PUNCT
bam-5830	719	1	p.l	p.l	PROPN
bam-5830	719	2	.	.	PROPN
bam-5830	719	3	puri	puri	PROPN
bam-5830	719	4	1,2	1,2	NUM
bam-5830	719	5	1	1	NUM
bam-5830	719	6	.	.	PUNCT
bam-5830	720	1	istituto	istituto	PROPN
bam-5830	720	2	di	di	PROPN
bam-5830	720	3	ricovero	ricovero	PROPN
bam-5830	720	4	e	e	PROPN
bam-5830	720	5	cura	cura	PROPN
bam-5830	720	6	a	a	PROPN
bam-5830	720	7	carattere	carattere	PROPN
bam-5830	720	8	scientifico	scientifico	PROPN
bam-5830	720	9	(	(	PUNCT
bam-5830	720	10	irccs	irccs	NOUN
bam-5830	720	11	)	)	PUNCT
bam-5830	720	12	fondazione	fondazione	NOUN
bam-5830	720	13	santa	santa	PROPN
bam-5830	720	14	lucia	lucia	PROPN
bam-5830	720	15	,	,	PUNCT
bam-5830	720	16	rome	rome	PROPN
bam-5830	720	17	,	,	PUNCT
bam-5830	720	18	italy	italy	PROPN
bam-5830	720	19	;	;	PUNCT
bam-5830	720	20	2	2	X
bam-5830	720	21	.	.	X
bam-5830	720	22	sanford	sanford	PROPN
bam-5830	720	23	-	-	PUNCT
bam-5830	720	24	burnham	burnham	PROPN
bam-5830	720	25	medical	medical	PROPN
bam-5830	720	26	research	research	PROPN
bam-5830	720	27	institute	institute	PROPN
bam-5830	720	28	,	,	PUNCT
bam-5830	720	29	sanford	sanford	PROPN
bam-5830	720	30	children	children	PROPN
bam-5830	720	31	’s	’s	PART
bam-5830	720	32	health	health	NOUN
bam-5830	720	33	research	research	NOUN
bam-5830	720	34	center	center	NOUN
bam-5830	720	35	,	,	PUNCT
bam-5830	720	36	la	la	PROPN
bam-5830	720	37	jolla	jolla	PROPN
bam-5830	720	38	,	,	PUNCT
bam-5830	720	39	california	california	PROPN
bam-5830	720	40	,	,	PUNCT
bam-5830	720	41	usa	usa	PROPN
bam-5830	720	42	e	e	PROPN
bam-5830	720	43	-	-	NOUN
bam-5830	720	44	mail	mail	NOUN
bam-5830	720	45	:	:	PUNCT
bam-5830	720	46	martinasandona2@gmail.com	martinasandona2@gmail.com	X
bam-5830	720	47	muscle	muscle	NOUN
bam-5830	720	48	regeneration	regeneration	NOUN
bam-5830	720	49	is	be	AUX
bam-5830	720	50	dependent	dependent	ADJ
bam-5830	720	51	upon	upon	SCONJ
bam-5830	720	52	a	a	DET
bam-5830	720	53	complex	complex	ADJ
bam-5830	720	54	interplay	interplay	NOUN
bam-5830	720	55	of	of	ADP
bam-5830	720	56	different	different	ADJ
bam-5830	720	57	cell	cell	NOUN
bam-5830	720	58	types	type	NOUN
bam-5830	720	59	in	in	ADP
bam-5830	720	60	the	the	DET
bam-5830	720	61	muscle	muscle	NOUN
bam-5830	720	62	stem	stem	NOUN
bam-5830	720	63	cell	cell	NOUN
bam-5830	720	64	niche	niche	NOUN
bam-5830	720	65	.	.	PUNCT
bam-5830	721	1	in	in	ADP
bam-5830	721	2	particular	particular	ADJ
bam-5830	721	3	,	,	PUNCT
bam-5830	721	4	the	the	DET
bam-5830	721	5	recently	recently	ADV
bam-5830	721	6	described	describe	VERB
bam-5830	721	7	population	population	NOUN
bam-5830	721	8	of	of	ADP
bam-5830	721	9	interstitial	interstitial	ADJ
bam-5830	721	10	fibro	fibro	PROPN
bam-5830	721	11	-	-	PUNCT
bam-5830	721	12	adipogenic	adipogenic	ADJ
bam-5830	721	13	progenitors	progenitor	NOUN
bam-5830	721	14	(	(	PUNCT
bam-5830	721	15	faps	fap	NOUN
bam-5830	721	16	)	)	PUNCT
bam-5830	721	17	and	and	CCONJ
bam-5830	721	18	satellite	satellite	NOUN
bam-5830	721	19	cells	cell	NOUN
bam-5830	721	20	(	(	PUNCT
bam-5830	721	21	muscs	musc	NOUN
bam-5830	721	22	)	)	PUNCT
bam-5830	721	23	establish	establish	VERB
bam-5830	721	24	a	a	DET
bam-5830	721	25	complex	complex	ADJ
bam-5830	721	26	network	network	NOUN
bam-5830	721	27	of	of	ADP
bam-5830	721	28	interactions	interaction	NOUN
bam-5830	721	29	to	to	PART
bam-5830	721	30	coordinate	coordinate	VERB
bam-5830	721	31	muscle	muscle	NOUN
bam-5830	721	32	regeneration	regeneration	NOUN
bam-5830	721	33	.	.	PUNCT
bam-5830	722	1	faps	fap	NOUN
bam-5830	722	2	are	be	AUX
bam-5830	722	3	able	able	ADJ
bam-5830	722	4	to	to	PART
bam-5830	722	5	promote	promote	VERB
bam-5830	722	6	satellite	satellite	NOUN
bam-5830	722	7	cell	cell	NOUN
bam-5830	722	8	differentiation	differentiation	NOUN
bam-5830	722	9	and	and	CCONJ
bam-5830	722	10	compensate	compensate	NOUN
bam-5830	722	11	for	for	ADP
bam-5830	722	12	muscle	muscle	NOUN
bam-5830	722	13	necrosis	necrosis	NOUN
bam-5830	722	14	.	.	PUNCT
bam-5830	723	1	in	in	ADP
bam-5830	723	2	our	our	PRON
bam-5830	723	3	recent	recent	ADJ
bam-5830	723	4	studies	study	NOUN
bam-5830	723	5	,	,	PUNCT
bam-5830	723	6	we	we	PRON
bam-5830	723	7	demonstrated	demonstrate	VERB
bam-5830	723	8	that	that	SCONJ
bam-5830	723	9	faps	fap	NOUN
bam-5830	723	10	are	be	AUX
bam-5830	723	11	the	the	DET
bam-5830	723	12	key	key	ADJ
bam-5830	723	13	cellular	cellular	ADJ
bam-5830	723	14	mediators	mediator	NOUN
bam-5830	723	15	of	of	ADP
bam-5830	723	16	the	the	DET
bam-5830	723	17	beneficial	beneficial	ADJ
bam-5830	723	18	effect	effect	NOUN
bam-5830	723	19	of	of	ADP
bam-5830	723	20	hdac	hdac	NOUN
bam-5830	723	21	inhibitors	inhibitor	NOUN
bam-5830	723	22	at	at	ADP
bam-5830	723	23	early	early	ADJ
bam-5830	723	24	stages	stage	NOUN
bam-5830	723	25	of	of	ADP
bam-5830	723	26	duchenne	duchenne	ADJ
bam-5830	723	27	muscular	muscular	ADJ
bam-5830	723	28	dystrophy	dystrophy	NOUN
bam-5830	723	29	(	(	PUNCT
bam-5830	723	30	dmd	dmd	NOUN
bam-5830	723	31	)	)	PUNCT
bam-5830	723	32	.	.	PUNCT
bam-5830	724	1	indeed	indeed	ADV
bam-5830	724	2	,	,	PUNCT
bam-5830	724	3	faps	fap	NOUN
bam-5830	724	4	,	,	PUNCT
bam-5830	724	5	from	from	ADP
bam-5830	724	6	young	young	ADJ
bam-5830	724	7	mdx	mdx	NOUN
bam-5830	724	8	mice	mouse	NOUN
bam-5830	724	9	hdaci	hdaci	NOUN
bam-5830	724	10	,	,	PUNCT
bam-5830	724	11	induce	induce	VERB
bam-5830	724	12	myogenesis	myogenesis	NOUN
bam-5830	724	13	at	at	ADP
bam-5830	724	14	expense	expense	NOUN
bam-5830	724	15	of	of	ADP
bam-5830	724	16	adipogenesis	adipogenesis	NOUN
bam-5830	724	17	and	and	CCONJ
bam-5830	724	18	enhance	enhance	VERB
bam-5830	724	19	their	their	PRON
bam-5830	724	20	ability	ability	NOUN
bam-5830	724	21	to	to	PART
bam-5830	724	22	support	support	VERB
bam-5830	724	23	muscs	muscs	ADJ
bam-5830	724	24	differentiation	differentiation	NOUN
bam-5830	724	25	.	.	PUNCT
bam-5830	725	1	conversely	conversely	ADV
bam-5830	725	2	,	,	PUNCT
bam-5830	725	3	faps	fap	NOUN
bam-5830	725	4	from	from	ADP
bam-5830	725	5	old	old	ADJ
bam-5830	725	6	mdx	mdx	NOUN
bam-5830	725	7	mice	mouse	NOUN
bam-5830	725	8	are	be	AUX
bam-5830	725	9	resistant	resistant	ADJ
bam-5830	725	10	to	to	ADP
bam-5830	725	11	hdaci	hdaci	NOUN
bam-5830	725	12	and	and	CCONJ
bam-5830	725	13	repress	repress	VERB
bam-5830	725	14	muscs	muscs	ADJ
bam-5830	725	15	differentiation	differentiation	NOUN
bam-5830	725	16	(	(	PUNCT
bam-5830	725	17	mozzetta	mozzetta	VERB
bam-5830	725	18	et	et	PROPN
bam-5830	725	19	al	al	PROPN
bam-5830	725	20	.	.	PROPN
bam-5830	725	21	,	,	PUNCT
bam-5830	725	22	2013	2013	NUM
bam-5830	725	23	;	;	PUNCT
bam-5830	725	24	saccone	saccone	NOUN
bam-5830	725	25	et	et	PROPN
bam-5830	725	26	al	al	PROPN
bam-5830	725	27	.	.	PROPN
bam-5830	725	28	,	,	PUNCT
bam-5830	725	29	2014	2014	NUM
bam-5830	725	30	)	)	PUNCT
bam-5830	725	31	.	.	PUNCT
bam-5830	726	1	given	give	VERB
bam-5830	726	2	the	the	DET
bam-5830	726	3	importance	importance	NOUN
bam-5830	726	4	of	of	ADP
bam-5830	726	5	the	the	DET
bam-5830	726	6	cross	cross	NOUN
bam-5830	726	7	-	-	NOUN
bam-5830	726	8	talk	talk	NOUN
bam-5830	726	9	between	between	ADP
bam-5830	726	10	faps	fap	NOUN
bam-5830	726	11	and	and	CCONJ
bam-5830	726	12	muscs	musc	NOUN
bam-5830	726	13	in	in	ADP
bam-5830	726	14	dmd	dmd	NOUN
bam-5830	726	15	progression	progression	NOUN
bam-5830	726	16	,	,	PUNCT
bam-5830	726	17	we	we	PRON
bam-5830	726	18	are	be	AUX
bam-5830	726	19	currently	currently	ADV
bam-5830	726	20	deciphering	decipher	VERB
bam-5830	726	21	the	the	DET
bam-5830	726	22	role	role	NOUN
bam-5830	726	23	of	of	ADP
bam-5830	726	24	fap	fap	NOUN
bam-5830	726	25	-	-	PUNCT
bam-5830	726	26	released	release	VERB
bam-5830	726	27	extracellular	extracellular	ADJ
bam-5830	726	28	vesicles	vesicle	NOUN
bam-5830	726	29	(	(	PUNCT
bam-5830	726	30	and	and	CCONJ
bam-5830	726	31	in	in	ADP
bam-5830	726	32	particular	particular	ADJ
bam-5830	726	33	the	the	DET
bam-5830	726	34	exosomes	exosome	NOUN
bam-5830	726	35	endosome	endosome	ADJ
bam-5830	726	36	derived	derive	VERB
bam-5830	726	37	vesicles	vesicle	NOUN
bam-5830	726	38	)	)	PUNCT
bam-5830	726	39	as	as	ADP
bam-5830	726	40	mediators	mediator	NOUN
bam-5830	726	41	of	of	ADP
bam-5830	726	42	the	the	DET
bam-5830	726	43	functional	functional	ADJ
bam-5830	726	44	interactions	interaction	NOUN
bam-5830	726	45	between	between	ADP
bam-5830	726	46	mononuclear	mononuclear	ADJ
bam-5830	726	47	cell	cell	NOUN
bam-5830	726	48	types	type	NOUN
bam-5830	726	49	that	that	PRON
bam-5830	726	50	contribute	contribute	VERB
bam-5830	726	51	to	to	ADP
bam-5830	726	52	muscle	muscle	NOUN
bam-5830	726	53	regeneration	regeneration	NOUN
bam-5830	726	54	.	.	PUNCT
bam-5830	727	1	*	*	PUNCT
bam-5830	727	2	*	*	PUNCT
bam-5830	727	3	*	*	PUNCT
bam-5830	727	4	*	*	PUNCT
bam-5830	727	5	*	*	VERB
bam-5830	727	6	abstracts	abstract	NOUN
bam-5830	727	7	of	of	ADP
bam-5830	727	8	the	the	DET
bam-5830	727	9	xii	xii	PROPN
bam-5830	727	10	iim	iim	NOUN
bam-5830	727	11	myology	myology	NOUN
bam-5830	727	12	meeting	meeting	NOUN
bam-5830	727	13	october	october	PROPN
bam-5830	727	14	1–4	1–4	PROPN
bam-5830	727	15	,	,	PUNCT
bam-5830	727	16	2015	2015	NUM
bam-5830	727	17	eur	eur	PROPN
bam-5830	727	18	j	j	PROPN
bam-5830	727	19	transl	transl	PROPN
bam-5830	727	20	myol	myol	PROPN
bam-5830	727	21	basic	basic	ADJ
bam-5830	727	22	appl	appl	NOUN
bam-5830	727	23	myol	myol	NOUN
bam-5830	727	24	2016	2016	NUM
bam-5830	727	25	;	;	PUNCT
bam-5830	727	26	26	26	NUM
bam-5830	727	27	(	(	PUNCT
bam-5830	727	28	1):2	1):2	NUM
bam-5830	727	29	-	-	SYM
bam-5830	727	30	24	24	NUM
bam-5830	727	31	this	this	DET
bam-5830	727	32	article	article	NOUN
bam-5830	727	33	is	be	AUX
bam-5830	727	34	distributed	distribute	VERB
bam-5830	727	35	under	under	ADP
bam-5830	727	36	the	the	DET
bam-5830	727	37	terms	term	NOUN
bam-5830	727	38	of	of	ADP
bam-5830	727	39	the	the	DET
bam-5830	727	40	creative	creative	ADJ
bam-5830	727	41	commons	common	NOUN
bam-5830	727	42	attribution	attribution	NOUN
bam-5830	727	43	noncommercial	noncommercial	ADJ
bam-5830	727	44	license	license	NOUN
bam-5830	727	45	(	(	PUNCT
bam-5830	727	46	cc	cc	NOUN
bam-5830	727	47	by	by	ADP
bam-5830	727	48	-	-	PUNCT
bam-5830	727	49	nc	nc	PROPN
bam-5830	727	50	4.0	4.0	NUM
bam-5830	727	51	)	)	PUNCT
bam-5830	727	52	which	which	PRON
bam-5830	727	53	permits	permit	VERB
bam-5830	727	54	any	any	DET
bam-5830	727	55	noncommercial	noncommercial	ADJ
bam-5830	727	56	use	use	NOUN
bam-5830	727	57	,	,	PUNCT
bam-5830	727	58	distribution	distribution	NOUN
bam-5830	727	59	,	,	PUNCT
bam-5830	727	60	and	and	CCONJ
bam-5830	727	61	reproduction	reproduction	NOUN
bam-5830	727	62	in	in	ADP
bam-5830	727	63	any	any	DET
bam-5830	727	64	medium	medium	NOUN
bam-5830	727	65	,	,	PUNCT
bam-5830	727	66	provided	provide	VERB
bam-5830	727	67	the	the	DET
bam-5830	727	68	original	original	ADJ
bam-5830	727	69	author(s	author(s	NOUN
bam-5830	727	70	)	)	PUNCT
bam-5830	727	71	and	and	CCONJ
bam-5830	727	72	source	source	NOUN
bam-5830	727	73	are	be	AUX
bam-5830	727	74	credited	credit	VERB
bam-5830	727	75	.	.	PUNCT
bam-5830	728	1	22	22	NUM
bam-5830	728	2	study	study	NOUN
bam-5830	728	3	of	of	ADP
bam-5830	728	4	physio	physio	NOUN
bam-5830	728	5	-	-	PUNCT
bam-5830	728	6	pathological	pathological	ADJ
bam-5830	728	7	mechanisms	mechanism	NOUN
bam-5830	728	8	implicated	implicate	VERB
bam-5830	728	9	in	in	ADP
bam-5830	728	10	sarcoglycanopathies	sarcoglycanopathie	NOUN
bam-5830	728	11	j.	j.	PROPN
bam-5830	728	12	marsolier	marsolier	PROPN
bam-5830	728	13	1,2	1,2	NUM
bam-5830	728	14	,	,	PUNCT
bam-5830	728	15	c.	c.	PROPN
bam-5830	728	16	patissier	patissier	PROPN
bam-5830	728	17	1,2	1,2	NUM
bam-5830	728	18	,	,	PUNCT
bam-5830	728	19	e.	e.	PROPN
bam-5830	728	20	gicquel	gicquel	PROPN
bam-5830	728	21	1,2	1,2	NUM
bam-5830	728	22	,	,	PUNCT
bam-5830	728	23	o.	o.	PROPN
bam-5830	728	24	adjali	adjali	PROPN
bam-5830	728	25	3	3	NUM
bam-5830	728	26	,	,	PUNCT
bam-5830	728	27	i.	i.	PROPN
bam-5830	728	28	richard	richard	PROPN
bam-5830	728	29	1,2	1,2	NUM
bam-5830	728	30	1	1	NUM
bam-5830	728	31	.	.	PUNCT
bam-5830	729	1	inserm	inserm	NOUN
bam-5830	729	2	,	,	PUNCT
bam-5830	729	3	u951	u951	PROPN
bam-5830	729	4	,	,	PUNCT
bam-5830	729	5	evry	evry	PROPN
bam-5830	729	6	,	,	PUNCT
bam-5830	729	7	france	france	PROPN
bam-5830	729	8	;	;	PUNCT
bam-5830	729	9	2	2	X
bam-5830	729	10	.	.	X
bam-5830	729	11	généthon	généthon	PROPN
bam-5830	729	12	,	,	PUNCT
bam-5830	729	13	r&d	r&d	NOUN
bam-5830	729	14	department	department	NOUN
bam-5830	729	15	,	,	PUNCT
bam-5830	729	16	integrare	integrare	NOUN
bam-5830	729	17	research	research	NOUN
bam-5830	729	18	unit	unit	NOUN
bam-5830	729	19	,	,	PUNCT
bam-5830	729	20	evry	evry	PROPN
bam-5830	729	21	,	,	PUNCT
bam-5830	729	22	france	france	PROPN
bam-5830	729	23	;	;	PUNCT
bam-5830	729	24	3	3	X
bam-5830	729	25	.	.	X
bam-5830	729	26	inserm	inserm	PROPN
bam-5830	729	27	umr	umr	PROPN
bam-5830	729	28	1089	1089	NUM
bam-5830	729	29	,	,	PUNCT
bam-5830	729	30	nantes	nantes	PROPN
bam-5830	729	31	university	university	NOUN
bam-5830	729	32	hospital	hospital	NOUN
bam-5830	729	33	,	,	PUNCT
bam-5830	729	34	nantes	nante	NOUN
bam-5830	729	35	,	,	PUNCT
bam-5830	729	36	france	france	PROPN
bam-5830	729	37	.	.	PUNCT
bam-5830	730	1	e	e	X
bam-5830	730	2	-	-	NOUN
bam-5830	730	3	mail	mail	NOUN
bam-5830	730	4	:	:	PUNCT
bam-5830	730	5	jmarsolier@genethon.fr	jmarsolier@genethon.fr	PROPN
bam-5830	730	6	limb	limb	PROPN
bam-5830	730	7	girdle	girdle	NOUN
bam-5830	730	8	muscular	muscular	ADJ
bam-5830	730	9	dystrophies	dystrophy	NOUN
bam-5830	730	10	are	be	AUX
bam-5830	730	11	rare	rare	ADJ
bam-5830	730	12	genetic	genetic	ADJ
bam-5830	730	13	diseases	disease	NOUN
bam-5830	730	14	,	,	PUNCT
bam-5830	730	15	characterized	characterize	VERB
bam-5830	730	16	by	by	ADP
bam-5830	730	17	weakness	weakness	NOUN
bam-5830	730	18	and	and	CCONJ
bam-5830	730	19	progressive	progressive	ADJ
bam-5830	730	20	muscular	muscular	ADJ
bam-5830	730	21	atrophy	atrophy	NOUN
bam-5830	730	22	.	.	PUNCT
bam-5830	731	1	a	a	DET
bam-5830	731	2	subfamily	subfamily	NOUN
bam-5830	731	3	of	of	ADP
bam-5830	731	4	lgmd2	lgmd2	PROPN
bam-5830	731	5	regroups	regroup	VERB
bam-5830	731	6	sarcoglycanopathies	sarcoglycanopathie	NOUN
bam-5830	731	7	caused	cause	VERB
bam-5830	731	8	by	by	ADP
bam-5830	731	9	mutations	mutation	NOUN
bam-5830	731	10	in	in	ADP
bam-5830	731	11	genes	gene	NOUN
bam-5830	731	12	coding	code	VERB
bam-5830	731	13	for	for	ADP
bam-5830	731	14	sarcoglycans	sarcoglycan	NOUN
bam-5830	731	15	.	.	PUNCT
bam-5830	732	1	these	these	DET
bam-5830	732	2	transmembrane	transmembrane	ADJ
bam-5830	732	3	proteins	protein	NOUN
bam-5830	732	4	are	be	AUX
bam-5830	732	5	part	part	NOUN
bam-5830	732	6	of	of	ADP
bam-5830	732	7	the	the	DET
bam-5830	732	8	dystrophin	dystrophin	ADJ
bam-5830	732	9	complex	complex	NOUN
bam-5830	732	10	that	that	PRON
bam-5830	732	11	protects	protect	VERB
bam-5830	732	12	muscle	muscle	NOUN
bam-5830	732	13	fibers	fiber	NOUN
bam-5830	732	14	against	against	ADP
bam-5830	732	15	mechanical	mechanical	ADJ
bam-5830	732	16	stress	stress	NOUN
bam-5830	732	17	due	due	ADP
bam-5830	732	18	to	to	ADP
bam-5830	732	19	contraction	contraction	NOUN
bam-5830	732	20	.	.	PUNCT
bam-5830	733	1	there	there	PRON
bam-5830	733	2	is	be	VERB
bam-5830	733	3	no	no	DET
bam-5830	733	4	treatment	treatment	NOUN
bam-5830	733	5	available	available	ADJ
bam-5830	733	6	for	for	ADP
bam-5830	733	7	these	these	DET
bam-5830	733	8	diseases.in	diseases.in	X
bam-5830	733	9	order	order	NOUN
bam-5830	733	10	to	to	PART
bam-5830	733	11	understand	understand	VERB
bam-5830	733	12	the	the	DET
bam-5830	733	13	molecular	molecular	ADJ
bam-5830	733	14	mechanisms	mechanism	NOUN
bam-5830	733	15	implicated	implicate	VERB
bam-5830	733	16	in	in	ADP
bam-5830	733	17	sarcoglycanopathies	sarcoglycanopathie	NOUN
bam-5830	733	18	and	and	CCONJ
bam-5830	733	19	to	to	PART
bam-5830	733	20	identify	identify	VERB
bam-5830	733	21	new	new	ADJ
bam-5830	733	22	therapeutic	therapeutic	ADJ
bam-5830	733	23	targets	target	NOUN
bam-5830	733	24	,	,	PUNCT
bam-5830	733	25	we	we	PRON
bam-5830	733	26	are	be	AUX
bam-5830	733	27	conducting	conduct	VERB
bam-5830	733	28	two	two	NUM
bam-5830	733	29	studies	study	NOUN
bam-5830	733	30	:	:	PUNCT
bam-5830	733	31	1	1	NUM
bam-5830	733	32	sg	sg	ADP
bam-5830	733	33	mutants	mutant	NOUN
bam-5830	733	34	are	be	AUX
bam-5830	733	35	not	not	PART
bam-5830	733	36	present	present	ADJ
bam-5830	733	37	at	at	ADP
bam-5830	733	38	the	the	DET
bam-5830	733	39	muscle	muscle	NOUN
bam-5830	733	40	fiber	fiber	NOUN
bam-5830	733	41	membrane	membrane	NOUN
bam-5830	733	42	because	because	SCONJ
bam-5830	733	43	they	they	PRON
bam-5830	733	44	are	be	AUX
bam-5830	733	45	retained	retain	VERB
bam-5830	733	46	in	in	ADP
bam-5830	733	47	the	the	DET
bam-5830	733	48	endoplasmic	endoplasmic	ADJ
bam-5830	733	49	reticulum	reticulum	NOUN
bam-5830	733	50	by	by	ADP
bam-5830	733	51	the	the	DET
bam-5830	733	52	quality	quality	NOUN
bam-5830	733	53	control	control	NOUN
bam-5830	733	54	(	(	PUNCT
bam-5830	733	55	erqc	erqc	NOUN
bam-5830	733	56	)	)	PUNCT
bam-5830	733	57	and	and	CCONJ
bam-5830	733	58	they	they	PRON
bam-5830	733	59	are	be	AUX
bam-5830	733	60	prematurely	prematurely	ADV
bam-5830	733	61	degraded	degrade	VERB
bam-5830	733	62	by	by	ADP
bam-5830	733	63	the	the	DET
bam-5830	733	64	proteasome	proteasome	NOUN
bam-5830	733	65	.	.	PUNCT
bam-5830	734	1	to	to	PART
bam-5830	734	2	study	study	VERB
bam-5830	734	3	the	the	DET
bam-5830	734	4	ercq	ercq	NOUN
bam-5830	734	5	pathways	pathway	NOUN
bam-5830	734	6	responsible	responsible	ADJ
bam-5830	734	7	for	for	ADP
bam-5830	734	8	sarcoglycan	sarcoglycan	ADJ
bam-5830	734	9	disposal	disposal	NOUN
bam-5830	734	10	at	at	ADP
bam-5830	734	11	molecular	molecular	ADJ
bam-5830	734	12	level	level	NOUN
bam-5830	734	13	,	,	PUNCT
bam-5830	734	14	we	we	PRON
bam-5830	734	15	first	first	ADV
bam-5830	734	16	generated	generate	VERB
bam-5830	734	17	cell	cell	NOUN
bam-5830	734	18	lines	line	NOUN
bam-5830	734	19	expressing	express	VERB
bam-5830	734	20	clonally	clonally	ADV
bam-5830	734	21	one	one	NUM
bam-5830	734	22	sg	sg	NOUN
bam-5830	734	23	mutant	mutant	NOUN
bam-5830	734	24	.	.	PUNCT
bam-5830	735	1	those	those	DET
bam-5830	735	2	clones	clone	NOUN
bam-5830	735	3	are	be	AUX
bam-5830	735	4	now	now	ADV
bam-5830	735	5	used	use	VERB
bam-5830	735	6	to	to	PART
bam-5830	735	7	investigate	investigate	VERB
bam-5830	735	8	the	the	DET
bam-5830	735	9	sgs	sgs	PROPN
bam-5830	735	10	cellular	cellular	ADJ
bam-5830	735	11	trafficking	trafficking	NOUN
bam-5830	735	12	mechanisms	mechanism	NOUN
bam-5830	735	13	and	and	CCONJ
bam-5830	735	14	then	then	ADV
bam-5830	735	15	to	to	PART
bam-5830	735	16	test	test	VERB
bam-5830	735	17	pharmacological	pharmacological	ADJ
bam-5830	735	18	compounds	compound	NOUN
bam-5830	735	19	modulating	modulate	VERB
bam-5830	735	20	ercq	ercq	NOUN
bam-5830	735	21	pathways	pathway	NOUN
bam-5830	735	22	.	.	PUNCT
bam-5830	736	1	2	2	NUM
bam-5830	736	2	–	–	PUNCT
bam-5830	736	3	in	in	ADP
bam-5830	736	4	these	these	DET
bam-5830	736	5	diseases	disease	NOUN
bam-5830	736	6	,	,	PUNCT
bam-5830	736	7	muscular	muscular	ADJ
bam-5830	736	8	atrophy	atrophy	NOUN
bam-5830	736	9	affects	affect	VERB
bam-5830	736	10	limb	limb	NOUN
bam-5830	736	11	muscles	muscle	NOUN
bam-5830	736	12	and	and	CCONJ
bam-5830	736	13	infrequently	infrequently	ADV
bam-5830	736	14	head	head	VERB
bam-5830	736	15	muscles	muscle	NOUN
bam-5830	736	16	.	.	PUNCT
bam-5830	737	1	to	to	PART
bam-5830	737	2	investigate	investigate	VERB
bam-5830	737	3	mechanisms	mechanism	NOUN
bam-5830	737	4	underlying	underlie	VERB
bam-5830	737	5	the	the	DET
bam-5830	737	6	fact	fact	NOUN
bam-5830	737	7	that	that	SCONJ
bam-5830	737	8	some	some	DET
bam-5830	737	9	muscles	muscle	NOUN
bam-5830	737	10	are	be	AUX
bam-5830	737	11	more	more	ADV
bam-5830	737	12	affected	affected	ADJ
bam-5830	737	13	than	than	ADP
bam-5830	737	14	other	other	ADJ
bam-5830	737	15	,	,	PUNCT
bam-5830	737	16	we	we	PRON
bam-5830	737	17	analyzed	analyze	VERB
bam-5830	737	18	different	different	ADJ
bam-5830	737	19	muscles	muscle	NOUN
bam-5830	737	20	to	to	PART
bam-5830	737	21	search	search	VERB
bam-5830	737	22	for	for	ADP
bam-5830	737	23	molecular	molecular	ADJ
bam-5830	737	24	differences	difference	NOUN
bam-5830	737	25	that	that	PRON
bam-5830	737	26	may	may	AUX
bam-5830	737	27	sign	sign	VERB
bam-5830	737	28	their	their	PRON
bam-5830	737	29	relative	relative	ADJ
bam-5830	737	30	sensitivity	sensitivity	NOUN
bam-5830	737	31	to	to	ADP
bam-5830	737	32	the	the	DET
bam-5830	737	33	genetic	genetic	ADJ
bam-5830	737	34	defects	defect	NOUN
bam-5830	737	35	.	.	PUNCT
bam-5830	738	1	the	the	DET
bam-5830	738	2	content	content	NOUN
bam-5830	738	3	in	in	ADP
bam-5830	738	4	micro	micro	NOUN
bam-5830	738	5	-	-	NOUN
bam-5830	738	6	rna	rna	NOUN
bam-5830	738	7	of	of	ADP
bam-5830	738	8	muscles	muscle	NOUN
bam-5830	738	9	from	from	ADP
bam-5830	738	10	the	the	DET
bam-5830	738	11	limbs	limb	NOUN
bam-5830	738	12	and	and	CCONJ
bam-5830	738	13	face	face	NOUN
bam-5830	738	14	of	of	ADP
bam-5830	738	15	macaca	macaca	NOUN
bam-5830	738	16	fascicularis	fascicularis	NOUN
bam-5830	738	17	was	be	AUX
bam-5830	738	18	explored	explore	VERB
bam-5830	738	19	.	.	PUNCT
bam-5830	739	1	experiments	experiment	NOUN
bam-5830	739	2	are	be	AUX
bam-5830	739	3	in	in	ADP
bam-5830	739	4	progress	progress	NOUN
bam-5830	739	5	to	to	PART
bam-5830	739	6	analyze	analyze	VERB
bam-5830	739	7	the	the	DET
bam-5830	739	8	function	function	NOUN
bam-5830	739	9	of	of	ADP
bam-5830	739	10	identified	identify	VERB
bam-5830	739	11	micro	micro	NOUN
bam-5830	739	12	-	-	NOUN
bam-5830	739	13	rnas	rna	NOUN
bam-5830	739	14	and	and	CCONJ
bam-5830	739	15	to	to	PART
bam-5830	739	16	evaluate	evaluate	VERB
bam-5830	739	17	their	their	PRON
bam-5830	739	18	therapeutic	therapeutic	ADJ
bam-5830	739	19	potential	potential	NOUN
bam-5830	739	20	for	for	ADP
bam-5830	739	21	sarcoglycanopathies	sarcoglycanopathie	NOUN
bam-5830	739	22	.	.	PUNCT
bam-5830	740	1	these	these	DET
bam-5830	740	2	projects	project	NOUN
bam-5830	740	3	will	will	AUX
bam-5830	740	4	improve	improve	VERB
bam-5830	740	5	the	the	DET
bam-5830	740	6	knowledge	knowledge	NOUN
bam-5830	740	7	on	on	ADP
bam-5830	740	8	physio	physio	ADJ
bam-5830	740	9	-	-	PUNCT
bam-5830	740	10	pathological	pathological	ADJ
bam-5830	740	11	mechanisms	mechanism	NOUN
bam-5830	740	12	of	of	ADP
bam-5830	740	13	sarcoglycanopathies	sarcoglycanopathie	NOUN
bam-5830	740	14	in	in	ADP
bam-5830	740	15	order	order	NOUN
bam-5830	740	16	to	to	PART
bam-5830	740	17	identify	identify	VERB
bam-5830	740	18	new	new	ADJ
bam-5830	740	19	therapies	therapy	NOUN
bam-5830	740	20	for	for	ADP
bam-5830	740	21	patients	patient	NOUN
bam-5830	740	22	.	.	PUNCT
bam-5830	741	1	*	*	PUNCT
bam-5830	741	2	*	*	PUNCT
bam-5830	741	3	*	*	PUNCT
bam-5830	741	4	*	*	PUNCT
bam-5830	741	5	*	*	PUNCT
bam-5830	741	6	molecular	molecular	ADJ
bam-5830	741	7	characterization	characterization	NOUN
bam-5830	741	8	of	of	ADP
bam-5830	741	9	dbe	dbe	PROPN
bam-5830	741	10	-	-	PUNCT
bam-5830	741	11	t	t	PROPN
bam-5830	741	12	lncrna	lncrna	NOUN
bam-5830	741	13	driving	drive	VERB
bam-5830	741	14	fshd	fshd	ADJ
bam-5830	741	15	muscular	muscular	ADJ
bam-5830	741	16	dystrophy	dystrophy	NOUN
bam-5830	741	17	r.	r.	PROPN
bam-5830	741	18	giambruno	giambruno	PROPN
bam-5830	741	19	1,2	1,2	NUM
bam-5830	741	20	,	,	PUNCT
bam-5830	741	21	s.	s.	PROPN
bam-5830	741	22	micheloni	micheloni	PROPN
bam-5830	741	23	1	1	NUM
bam-5830	741	24	,	,	PUNCT
bam-5830	741	25	g.	g.	PROPN
bam-5830	741	26	ferri	ferri	PROPN
bam-5830	741	27	1,2	1,2	NUM
bam-5830	741	28	,	,	PUNCT
bam-5830	741	29	m.	m.	NOUN
bam-5830	741	30	jothi	jothi	ADJ
bam-5830	741	31	1	1	NUM
bam-5830	741	32	,	,	PUNCT
bam-5830	741	33	d.	d.	PROPN
bam-5830	741	34	s.	s.	PROPN
bam-5830	741	35	cabianca	cabianca	PROPN
bam-5830	741	36	1	1	NUM
bam-5830	741	37	,	,	PUNCT
bam-5830	741	38	j.	j.	PROPN
bam-5830	741	39	huber	huber	PROPN
bam-5830	741	40	1	1	NUM
bam-5830	741	41	,	,	PUNCT
bam-5830	741	42	s.	s.	PROPN
bam-5830	741	43	warner	warner	PROPN
bam-5830	741	44	1	1	NUM
bam-5830	741	45	,	,	PUNCT
bam-5830	741	46	d.	d.	PROPN
bam-5830	741	47	gabellini	gabellini	VERB
bam-5830	741	48	1	1	NUM
bam-5830	741	49	1	1	NUM
bam-5830	741	50	dulbecco	dulbecco	NOUN
bam-5830	741	51	telethon	telethon	NOUN
bam-5830	741	52	institute	institute	NOUN
bam-5830	741	53	and	and	CCONJ
bam-5830	741	54	division	division	NOUN
bam-5830	741	55	of	of	ADP
bam-5830	741	56	regenerative	regenerative	ADJ
bam-5830	741	57	medicine	medicine	NOUN
bam-5830	741	58	,	,	PUNCT
bam-5830	741	59	stem	stem	NOUN
bam-5830	741	60	cells	cell	NOUN
bam-5830	741	61	,	,	PUNCT
bam-5830	741	62	and	and	CCONJ
bam-5830	741	63	gene	gene	NOUN
bam-5830	741	64	therapy	therapy	NOUN
bam-5830	741	65	,	,	PUNCT
bam-5830	741	66	san	san	PROPN
bam-5830	741	67	raffaele	raffaele	PROPN
bam-5830	741	68	scientific	scientific	PROPN
bam-5830	741	69	institute	institute	PROPN
bam-5830	741	70	,	,	PUNCT
bam-5830	741	71	milano	milano	PROPN
bam-5830	741	72	,	,	PUNCT
bam-5830	741	73	italy	italy	PROPN
bam-5830	741	74	;	;	PUNCT
bam-5830	741	75	2	2	X
bam-5830	741	76	.	.	X
bam-5830	741	77	università	università	PROPN
bam-5830	741	78	vita	vita	PROPN
bam-5830	741	79	-	-	PUNCT
bam-5830	741	80	salute	salute	NOUN
bam-5830	741	81	san	san	PROPN
bam-5830	741	82	raffaele	raffaele	PROPN
bam-5830	741	83	,	,	PUNCT
bam-5830	741	84	milano	milano	PROPN
bam-5830	741	85	,	,	PUNCT
bam-5830	741	86	italy	italy	PROPN
bam-5830	741	87	e	e	PROPN
bam-5830	741	88	-	-	NOUN
bam-5830	741	89	mail	mail	NOUN
bam-5830	741	90	:	:	PUNCT
bam-5830	741	91	giambruno.roberto@hsr.it	giambruno.roberto@hsr.it	DET
bam-5830	741	92	facioscapulohumeral	facioscapulohumeral	ADJ
bam-5830	741	93	muscular	muscular	ADJ
bam-5830	741	94	dystrophy	dystrophy	NOUN
bam-5830	741	95	(	(	PUNCT
bam-5830	741	96	fshd	fshd	ADJ
bam-5830	741	97	)	)	PUNCT
bam-5830	741	98	is	be	AUX
bam-5830	741	99	one	one	NUM
bam-5830	741	100	of	of	ADP
bam-5830	741	101	the	the	DET
bam-5830	741	102	most	most	ADV
bam-5830	741	103	common	common	ADJ
bam-5830	741	104	human	human	ADJ
bam-5830	741	105	myopathies	myopathy	NOUN
bam-5830	741	106	and	and	CCONJ
bam-5830	741	107	arises	arise	VERB
bam-5830	741	108	with	with	ADP
bam-5830	741	109	progressive	progressive	ADJ
bam-5830	741	110	wasting	wasting	NOUN
bam-5830	741	111	of	of	ADP
bam-5830	741	112	facial	facial	ADJ
bam-5830	741	113	mimic	mimic	ADJ
bam-5830	741	114	muscles	muscle	NOUN
bam-5830	741	115	as	as	ADV
bam-5830	741	116	well	well	ADV
bam-5830	741	117	as	as	ADP
bam-5830	741	118	upper	upper	ADJ
bam-5830	741	119	arms	arm	NOUN
bam-5830	741	120	and	and	CCONJ
bam-5830	741	121	shoulder	shoulder	NOUN
bam-5830	741	122	girdle	girdle	NOUN
bam-5830	741	123	muscles	muscle	NOUN
bam-5830	741	124	.	.	PUNCT
bam-5830	742	1	in	in	ADP
bam-5830	742	2	95	95	NUM
bam-5830	742	3	%	%	NOUN
bam-5830	742	4	of	of	ADP
bam-5830	742	5	the	the	DET
bam-5830	742	6	cases	case	NOUN
bam-5830	742	7	,	,	PUNCT
bam-5830	742	8	fshd	fshd	ADJ
bam-5830	742	9	is	be	AUX
bam-5830	742	10	associated	associate	VERB
bam-5830	742	11	with	with	ADP
bam-5830	742	12	the	the	DET
bam-5830	742	13	copy	copy	NOUN
bam-5830	742	14	number	number	NOUN
bam-5830	742	15	reduction	reduction	NOUN
bam-5830	742	16	of	of	ADP
bam-5830	742	17	d4z4	d4z4	PUNCT
bam-5830	742	18	macrosatellite	macrosatellite	PROPN
bam-5830	742	19	repeats	repeat	NOUN
bam-5830	742	20	at	at	ADP
bam-5830	742	21	the	the	DET
bam-5830	742	22	subtelomeric	subtelomeric	ADJ
bam-5830	742	23	region	region	NOUN
bam-5830	742	24	of	of	ADP
bam-5830	742	25	chromosome	chromosome	NOUN
bam-5830	742	26	4	4	NUM
bam-5830	742	27	(	(	PUNCT
bam-5830	742	28	4q35	4q35	NUM
bam-5830	742	29	)	)	PUNCT
bam-5830	742	30	.	.	PUNCT
bam-5830	743	1	this	this	DET
bam-5830	743	2	change	change	NOUN
bam-5830	743	3	is	be	AUX
bam-5830	743	4	associated	associate	VERB
bam-5830	743	5	with	with	ADP
bam-5830	743	6	an	an	DET
bam-5830	743	7	epigenetic	epigenetic	ADJ
bam-5830	743	8	deregulation	deregulation	NOUN
bam-5830	743	9	of	of	ADP
bam-5830	743	10	the	the	DET
bam-5830	743	11	region	region	NOUN
bam-5830	743	12	that	that	PRON
bam-5830	743	13	ultimately	ultimately	ADV
bam-5830	743	14	leads	lead	VERB
bam-5830	743	15	to	to	ADP
bam-5830	743	16	the	the	DET
bam-5830	743	17	de	de	NOUN
bam-5830	743	18	-	-	NOUN
bam-5830	743	19	repression	repression	NOUN
bam-5830	743	20	of	of	ADP
bam-5830	743	21	nearby	nearby	ADJ
bam-5830	743	22	genes	gene	NOUN
bam-5830	743	23	,	,	PUNCT
bam-5830	743	24	such	such	ADJ
bam-5830	743	25	as	as	ADP
bam-5830	743	26	dux4	dux4	NOUN
bam-5830	743	27	and	and	CCONJ
bam-5830	743	28	frg1	frg1	PROPN
bam-5830	743	29	that	that	PRON
bam-5830	743	30	have	have	AUX
bam-5830	743	31	been	be	AUX
bam-5830	743	32	reported	report	VERB
bam-5830	743	33	to	to	PART
bam-5830	743	34	contribute	contribute	VERB
bam-5830	743	35	to	to	ADP
bam-5830	743	36	the	the	DET
bam-5830	743	37	muscular	muscular	ADJ
bam-5830	743	38	dystrophic	dystrophic	ADJ
bam-5830	743	39	phenotype	phenotype	NOUN
bam-5830	743	40	observed	observe	VERB
bam-5830	743	41	in	in	ADP
bam-5830	743	42	fshd	fshd	ADJ
bam-5830	743	43	patients	patient	NOUN
bam-5830	743	44	.	.	PUNCT
bam-5830	744	1	the	the	DET
bam-5830	744	2	chromatin	chromatin	NOUN
bam-5830	744	3	-	-	PUNCT
bam-5830	744	4	associated	associate	VERB
bam-5830	744	5	lncrna	lncrna	NOUN
bam-5830	744	6	dbe	dbe	PROPN
bam-5830	744	7	-	-	PUNCT
bam-5830	744	8	t	t	PROPN
bam-5830	744	9	,	,	PUNCT
bam-5830	744	10	encoded	encode	VERB
bam-5830	744	11	by	by	ADP
bam-5830	744	12	the	the	DET
bam-5830	744	13	fshd	fshd	ADJ
bam-5830	744	14	locus	locus	NOUN
bam-5830	744	15	,	,	PUNCT
bam-5830	744	16	has	have	AUX
bam-5830	744	17	been	be	AUX
bam-5830	744	18	shown	show	VERB
bam-5830	744	19	to	to	PART
bam-5830	744	20	be	be	AUX
bam-5830	744	21	one	one	NUM
bam-5830	744	22	of	of	ADP
bam-5830	744	23	the	the	DET
bam-5830	744	24	main	main	ADJ
bam-5830	744	25	players	player	NOUN
bam-5830	744	26	of	of	ADP
bam-5830	744	27	such	such	ADJ
bam-5830	744	28	event	event	NOUN
bam-5830	744	29	,	,	PUNCT
bam-5830	744	30	though	though	SCONJ
bam-5830	744	31	the	the	DET
bam-5830	744	32	molecular	molecular	ADJ
bam-5830	744	33	mechanism	mechanism	NOUN
bam-5830	744	34	has	have	AUX
bam-5830	744	35	not	not	PART
bam-5830	744	36	been	be	AUX
bam-5830	744	37	yet	yet	ADV
bam-5830	744	38	fully	fully	ADV
bam-5830	744	39	elucidated	elucidated	ADJ
bam-5830	744	40	.	.	PUNCT
bam-5830	745	1	dbe	dbe	PROPN
bam-5830	745	2	-	-	PUNCT
bam-5830	745	3	t	t	PROPN
bam-5830	745	4	is	be	AUX
bam-5830	745	5	preferentially	preferentially	ADV
bam-5830	745	6	expressed	express	VERB
bam-5830	745	7	in	in	ADP
bam-5830	745	8	fshd	fshd	ADJ
bam-5830	745	9	patients	patient	NOUN
bam-5830	745	10	where	where	SCONJ
bam-5830	745	11	it	it	PRON
bam-5830	745	12	favors	favor	VERB
bam-5830	745	13	the	the	DET
bam-5830	745	14	transcription	transcription	NOUN
bam-5830	745	15	of	of	ADP
bam-5830	745	16	the	the	DET
bam-5830	745	17	4q35	4q35	NUM
bam-5830	745	18	genes	gene	NOUN
bam-5830	745	19	thanks	thank	NOUN
bam-5830	745	20	to	to	ADP
bam-5830	745	21	the	the	DET
bam-5830	745	22	recruitment	recruitment	NOUN
bam-5830	745	23	of	of	ADP
bam-5830	745	24	the	the	DET
bam-5830	745	25	histone	histone	NOUN
bam-5830	745	26	methyl	methyl	NOUN
bam-5830	745	27	transferase	transferase	NOUN
bam-5830	745	28	of	of	ADP
bam-5830	745	29	the	the	DET
bam-5830	745	30	trithorax	trithorax	PROPN
bam-5830	745	31	group	group	NOUN
bam-5830	745	32	of	of	ADP
bam-5830	745	33	epigenetic	epigenetic	ADJ
bam-5830	745	34	activators	activator	NOUN
bam-5830	745	35	ash1l	ash1l	PROPN
bam-5830	745	36	.	.	PUNCT
bam-5830	746	1	interestingly	interestingly	ADV
bam-5830	746	2	,	,	PUNCT
bam-5830	746	3	through	through	ADP
bam-5830	746	4	a	a	DET
bam-5830	746	5	structural	structural	ADJ
bam-5830	746	6	/	/	SYM
bam-5830	746	7	functional	functional	ADJ
bam-5830	746	8	analysis	analysis	NOUN
bam-5830	746	9	,	,	PUNCT
bam-5830	746	10	we	we	PRON
bam-5830	746	11	have	have	AUX
bam-5830	746	12	recognized	recognize	VERB
bam-5830	746	13	several	several	ADJ
bam-5830	746	14	dbe	dbe	PROPN
bam-5830	746	15	-	-	PUNCT
bam-5830	746	16	t	t	NOUN
bam-5830	746	17	functional	functional	ADJ
bam-5830	746	18	domains	domain	NOUN
bam-5830	746	19	that	that	PRON
bam-5830	746	20	can	can	AUX
bam-5830	746	21	be	be	AUX
bam-5830	746	22	exploited	exploit	VERB
bam-5830	746	23	as	as	ADP
bam-5830	746	24	new	new	ADJ
bam-5830	746	25	molecular	molecular	ADJ
bam-5830	746	26	targets	target	NOUN
bam-5830	746	27	for	for	ADP
bam-5830	746	28	therapeutic	therapeutic	ADJ
bam-5830	746	29	purposes	purpose	NOUN
bam-5830	746	30	.	.	PUNCT
bam-5830	747	1	specifically	specifically	ADV
bam-5830	747	2	,	,	PUNCT
bam-5830	747	3	we	we	PRON
bam-5830	747	4	have	have	AUX
bam-5830	747	5	identified	identify	VERB
bam-5830	747	6	a	a	DET
bam-5830	747	7	region	region	NOUN
bam-5830	747	8	and	and	CCONJ
bam-5830	747	9	the	the	DET
bam-5830	747	10	molecular	molecular	ADJ
bam-5830	747	11	mechanism	mechanism	NOUN
bam-5830	747	12	required	require	VERB
bam-5830	747	13	for	for	ADP
bam-5830	747	14	dbe	dbe	PROPN
bam-5830	747	15	-	-	PUNCT
bam-5830	747	16	t	t	PROPN
bam-5830	747	17	tethering	tethering	NOUN
bam-5830	747	18	to	to	ADP
bam-5830	747	19	the	the	DET
bam-5830	747	20	chromatin	chromatin	NOUN
bam-5830	747	21	.	.	PUNCT
bam-5830	748	1	in	in	ADP
bam-5830	748	2	addition	addition	NOUN
bam-5830	748	3	,	,	PUNCT
bam-5830	748	4	we	we	PRON
bam-5830	748	5	have	have	AUX
bam-5830	748	6	mapped	map	VERB
bam-5830	748	7	the	the	DET
bam-5830	748	8	minimal	minimal	ADJ
bam-5830	748	9	binding	bind	VERB
bam-5830	748	10	domains	domain	NOUN
bam-5830	748	11	in	in	ADP
bam-5830	748	12	ash1l	ash1l	PROPN
bam-5830	748	13	and	and	CCONJ
bam-5830	748	14	dbe	dbe	PROPN
bam-5830	748	15	-	-	PROPN
bam-5830	748	16	t.	t.	PROPN
bam-5830	748	17	finally	finally	ADV
bam-5830	748	18	,	,	PUNCT
bam-5830	748	19	we	we	PRON
bam-5830	748	20	have	have	AUX
bam-5830	748	21	highlighted	highlight	VERB
bam-5830	748	22	a	a	DET
bam-5830	748	23	portion	portion	NOUN
bam-5830	748	24	of	of	ADP
bam-5830	748	25	dbe	dbe	PROPN
bam-5830	748	26	-	-	PUNCT
bam-5830	748	27	t	t	PROPN
bam-5830	748	28	required	require	VERB
bam-5830	748	29	to	to	PART
bam-5830	748	30	positively	positively	ADV
bam-5830	748	31	promote	promote	VERB
bam-5830	748	32	transcription	transcription	NOUN
bam-5830	748	33	.	.	PUNCT
bam-5830	749	1	in	in	ADP
bam-5830	749	2	agreement	agreement	NOUN
bam-5830	749	3	,	,	PUNCT
bam-5830	749	4	a	a	DET
bam-5830	749	5	dbe	dbe	PROPN
bam-5830	749	6	-	-	PUNCT
bam-5830	749	7	t	t	PROPN
bam-5830	749	8	mutant	mutant	NOUN
bam-5830	749	9	lacking	lack	VERB
bam-5830	749	10	this	this	DET
bam-5830	749	11	region	region	NOUN
bam-5830	749	12	is	be	AUX
bam-5830	749	13	unable	unable	ADJ
bam-5830	749	14	to	to	PART
bam-5830	749	15	trigger	trigger	VERB
bam-5830	749	16	transcription	transcription	NOUN
bam-5830	749	17	.	.	PUNCT
bam-5830	750	1	currently	currently	ADV
bam-5830	750	2	,	,	PUNCT
bam-5830	750	3	through	through	ADP
bam-5830	750	4	proteomic	proteomic	ADJ
bam-5830	750	5	approaches	approach	NOUN
bam-5830	750	6	,	,	PUNCT
bam-5830	750	7	we	we	PRON
bam-5830	750	8	are	be	AUX
bam-5830	750	9	investigating	investigate	VERB
bam-5830	750	10	dbe	dbe	PROPN
bam-5830	750	11	-	-	PUNCT
bam-5830	750	12	t	t	NOUN
bam-5830	750	13	protein	protein	NOUN
bam-5830	750	14	partners	partner	NOUN
bam-5830	750	15	that	that	PRON
bam-5830	750	16	are	be	AUX
bam-5830	750	17	specific	specific	ADJ
bam-5830	750	18	for	for	ADP
bam-5830	750	19	each	each	DET
bam-5830	750	20	dbe	dbe	PROPN
bam-5830	750	21	-	-	PUNCT
bam-5830	750	22	t	t	NOUN
bam-5830	750	23	functional	functional	ADJ
bam-5830	750	24	domain	domain	NOUN
bam-5830	750	25	.	.	PUNCT
bam-5830	751	1	our	our	PRON
bam-5830	751	2	goal	goal	NOUN
bam-5830	751	3	is	be	AUX
bam-5830	751	4	to	to	PART
bam-5830	751	5	identify	identify	VERB
bam-5830	751	6	unknown	unknown	ADJ
bam-5830	751	7	molecular	molecular	ADJ
bam-5830	751	8	players	player	NOUN
bam-5830	751	9	that	that	PRON
bam-5830	751	10	,	,	PUNCT
bam-5830	751	11	similarly	similarly	ADV
bam-5830	751	12	to	to	ADP
bam-5830	751	13	ash1l	ash1l	PROPN
bam-5830	751	14	,	,	PUNCT
bam-5830	751	15	are	be	AUX
bam-5830	751	16	recruited	recruit	VERB
bam-5830	751	17	by	by	ADP
bam-5830	751	18	dbe	dbe	PROPN
bam-5830	751	19	-	-	PUNCT
bam-5830	751	20	t	t	PROPN
bam-5830	751	21	to	to	ADP
bam-5830	751	22	the	the	DET
bam-5830	751	23	fshd	fshd	ADJ
bam-5830	751	24	locus	locus	NOUN
bam-5830	751	25	and	and	CCONJ
bam-5830	751	26	can	can	AUX
bam-5830	751	27	play	play	VERB
bam-5830	751	28	a	a	DET
bam-5830	751	29	role	role	NOUN
bam-5830	751	30	in	in	ADP
bam-5830	751	31	the	the	DET
bam-5830	751	32	disease	disease	NOUN
bam-5830	751	33	.	.	PUNCT
bam-5830	752	1	overall	overall	ADV
bam-5830	752	2	,	,	PUNCT
bam-5830	752	3	our	our	PRON
bam-5830	752	4	study	study	NOUN
bam-5830	752	5	elucidates	elucidate	VERB
bam-5830	752	6	the	the	DET
bam-5830	752	7	molecular	molecular	ADJ
bam-5830	752	8	mechanism	mechanism	NOUN
bam-5830	752	9	of	of	ADP
bam-5830	752	10	dbe	dbe	PROPN
bam-5830	752	11	-	-	PUNCT
bam-5830	752	12	t	t	PROPN
bam-5830	752	13	in	in	ADP
bam-5830	752	14	fshd	fshd	ADJ
bam-5830	752	15	and	and	CCONJ
bam-5830	752	16	might	might	AUX
bam-5830	752	17	unveil	unveil	VERB
bam-5830	752	18	new	new	ADJ
bam-5830	752	19	therapeutic	therapeutic	ADJ
bam-5830	752	20	targets	target	NOUN
bam-5830	752	21	for	for	ADP
bam-5830	752	22	the	the	DET
bam-5830	752	23	treatment	treatment	NOUN
bam-5830	752	24	of	of	ADP
bam-5830	752	25	the	the	DET
bam-5830	752	26	disease	disease	NOUN
bam-5830	752	27	.	.	PUNCT
bam-5830	753	1	*	*	PUNCT
bam-5830	754	1	*	*	PUNCT
bam-5830	754	2	*	*	PUNCT
bam-5830	754	3	*	*	PUNCT
bam-5830	754	4	*	*	PUNCT
bam-5830	754	5	*	*	PUNCT
bam-5830	754	6	*	*	PUNCT
bam-5830	754	7	*	*	PUNCT
bam-5830	754	8	*	*	PUNCT
bam-5830	754	9	*	*	PUNCT
bam-5830	754	10	*	*	PUNCT
bam-5830	754	11	*	*	PUNCT
bam-5830	754	12	*	*	PUNCT
bam-5830	754	13	*	*	PUNCT
bam-5830	754	14	*	*	PUNCT
bam-5830	754	15	*	*	PUNCT
bam-5830	754	16	*	*	PUNCT
bam-5830	754	17	*	*	PUNCT
bam-5830	754	18	*	*	PUNCT
bam-5830	754	19	*	*	PUNCT
bam-5830	754	20	*	*	PUNCT
bam-5830	754	21	*	*	PUNCT
bam-5830	754	22	*	*	PUNCT
bam-5830	754	23	*	*	PUNCT
bam-5830	754	24	*	*	PUNCT
bam-5830	754	25	*	*	PUNCT
bam-5830	754	26	*	*	PUNCT
bam-5830	754	27	*	*	PUNCT
bam-5830	754	28	*	*	PUNCT
bam-5830	754	29	*	*	PUNCT
bam-5830	754	30	*	*	PUNCT
bam-5830	754	31	*	*	PUNCT
bam-5830	754	32	*	*	VERB
bam-5830	754	33	abstracts	abstract	NOUN
bam-5830	754	34	of	of	ADP
bam-5830	754	35	the	the	DET
bam-5830	754	36	xii	xii	PROPN
bam-5830	754	37	iim	iim	NOUN
bam-5830	754	38	myology	myology	NOUN
bam-5830	754	39	meeting	meet	VERB
bam-5830	754	40	1	1	NUM
bam-5830	754	41	-	-	SYM
bam-5830	754	42	4	4	NUM
bam-5830	754	43	october	october	NOUN
bam-5830	754	44	2015	2015	NUM
bam-5830	754	45	eur	eur	PROPN
bam-5830	754	46	j	j	PROPN
bam-5830	754	47	transl	transl	PROPN
bam-5830	754	48	myol	myol	PROPN
bam-5830	754	49	basic	basic	ADJ
bam-5830	754	50	appl	appl	NOUN
bam-5830	754	51	myol	myol	NOUN
bam-5830	754	52	2016	2016	NUM
bam-5830	754	53	;	;	PUNCT
bam-5830	754	54	26	26	NUM
bam-5830	754	55	(	(	PUNCT
bam-5830	754	56	1	1	NUM
bam-5830	754	57	):	):	PUNCT
bam-5830	754	58	2	2	NUM
bam-5830	754	59	-	-	SYM
bam-5830	754	60	24	24	NUM
bam-5830	754	61	this	this	DET
bam-5830	754	62	article	article	NOUN
bam-5830	754	63	is	be	AUX
bam-5830	754	64	distributed	distribute	VERB
bam-5830	754	65	under	under	ADP
bam-5830	754	66	the	the	DET
bam-5830	754	67	terms	term	NOUN
bam-5830	754	68	of	of	ADP
bam-5830	754	69	the	the	DET
bam-5830	754	70	creative	creative	ADJ
bam-5830	754	71	commons	common	NOUN
bam-5830	754	72	attribution	attribution	NOUN
bam-5830	754	73	noncommercial	noncommercial	ADJ
bam-5830	754	74	license	license	NOUN
bam-5830	754	75	(	(	PUNCT
bam-5830	754	76	cc	cc	NOUN
bam-5830	754	77	by	by	ADP
bam-5830	754	78	-	-	PUNCT
bam-5830	754	79	nc	nc	PROPN
bam-5830	754	80	4.0	4.0	NUM
bam-5830	754	81	)	)	PUNCT
bam-5830	754	82	which	which	PRON
bam-5830	754	83	permits	permit	VERB
bam-5830	754	84	any	any	DET
bam-5830	754	85	noncommercial	noncommercial	ADJ
bam-5830	754	86	use	use	NOUN
bam-5830	754	87	,	,	PUNCT
bam-5830	754	88	distribution	distribution	NOUN
bam-5830	754	89	,	,	PUNCT
bam-5830	754	90	and	and	CCONJ
bam-5830	754	91	reproduction	reproduction	NOUN
bam-5830	754	92	in	in	ADP
bam-5830	754	93	any	any	DET
bam-5830	754	94	medium	medium	NOUN
bam-5830	754	95	,	,	PUNCT
bam-5830	754	96	provided	provide	VERB
bam-5830	754	97	the	the	DET
bam-5830	754	98	original	original	ADJ
bam-5830	754	99	author(s	author(s	NOUN
bam-5830	754	100	)	)	PUNCT
bam-5830	754	101	and	and	CCONJ
bam-5830	754	102	source	source	NOUN
bam-5830	754	103	are	be	AUX
bam-5830	754	104	credited	credit	VERB
bam-5830	754	105	.	.	PUNCT
bam-5830	755	1	23	23	NUM
bam-5830	755	2	index	index	NOUN
bam-5830	755	3	adamo	adamo	PROPN
bam-5830	755	4	s.	s.	PROPN
bam-5830	755	5	3,19	3,19	PROPN
bam-5830	755	6	adjali	adjali	PROPN
bam-5830	755	7	o.	o.	NOUN
bam-5830	755	8	22	22	NUM
bam-5830	755	9	albiero	albiero	NOUN
bam-5830	755	10	m.	m.	NOUN
bam-5830	755	11	11,15	11,15	NUM
bam-5830	755	12	andronache	andronache	PROPN
bam-5830	755	13	a.	a.	PROPN
bam-5830	755	14	16	16	NUM
bam-5830	755	15	armani	armani	PROPN
bam-5830	755	16	a.	a.	PROPN
bam-5830	755	17	12	12	NUM
bam-5830	755	18	badodi	badodi	PROPN
bam-5830	755	19	s	s	PART
bam-5830	755	20	3	3	NUM
bam-5830	755	21	ballarino	ballarino	NOUN
bam-5830	755	22	m.	m.	NOUN
bam-5830	755	23	20	20	NUM
bam-5830	755	24	ballarò	ballarò	PROPN
bam-5830	755	25	r.	r.	NOUN
bam-5830	755	26	9	9	NUM
bam-5830	755	27	ballarò	ballarò	NOUN
bam-5830	755	28	r.	r.	PROPN
bam-5830	755	29	10	10	NUM
bam-5830	755	30	bang	bang	PROPN
bam-5830	755	31	m.l	m.l	PROPN
bam-5830	755	32	15	15	NUM
bam-5830	755	33	barone	barone	NOUN
bam-5830	755	34	v.	v.	ADP
bam-5830	755	35	21	21	NUM
bam-5830	755	36	baruffaldi	baruffaldi	PROPN
bam-5830	755	37	f.	f.	PROPN
bam-5830	755	38	3	3	NUM
bam-5830	755	39	baruffaldi	baruffaldi	PROPN
bam-5830	755	40	f.	f.	PROPN
bam-5830	755	41	4	4	NUM
bam-5830	755	42	basile	basile	NOUN
bam-5830	755	43	v.	v.	ADP
bam-5830	755	44	4	4	NUM
bam-5830	755	45	battini	battini	NOUN
bam-5830	755	46	r	r	NOUN
bam-5830	755	47	3	3	NUM
bam-5830	755	48	battistini	battistini	NOUN
bam-5830	755	49	c.	c.	PROPN
bam-5830	755	50	8	8	NUM
bam-5830	755	51	beccafico	beccafico	PROPN
bam-5830	755	52	s.	s.	PROPN
bam-5830	755	53	3	3	NUM
bam-5830	755	54	behrens	behrens	PROPN
bam-5830	755	55	j.	j.	PROPN
bam-5830	755	56	13	13	PROPN
bam-5830	755	57	beltrà	beltrà	PROPN
bam-5830	755	58	bach	bach	PROPN
bam-5830	755	59	m	m	PROPN
bam-5830	755	60	10	10	NUM
bam-5830	755	61	berghella	berghella	NOUN
bam-5830	755	62	l.	l.	NOUN
bam-5830	755	63	9	9	NUM
bam-5830	755	64	bernadzki	bernadzki	VERB
bam-5830	755	65	k.	k.	PROPN
bam-5830	755	66	7	7	NUM
bam-5830	755	67	bernardini	bernardini	PROPN
bam-5830	755	68	s	s	PART
bam-5830	755	69	16	16	NUM
bam-5830	755	70	bernkopf	bernkopf	VERB
bam-5830	755	71	d.	d.	PROPN
bam-5830	755	72	13	13	NUM
bam-5830	755	73	bianconi	bianconi	NOUN
bam-5830	755	74	v.	v.	ADP
bam-5830	755	75	16	16	NUM
bam-5830	755	76	bisceglie	bisceglie	PROPN
bam-5830	755	77	l.	l.	PROPN
bam-5830	755	78	20	20	NUM
bam-5830	755	79	bonaldo	bonaldo	ADJ
bam-5830	755	80	p.	p.	NOUN
bam-5830	755	81	15,20	15,20	NUM
bam-5830	755	82	boncompagni	boncompagni	NOUN
bam-5830	755	83	s.	s.	PROPN
bam-5830	755	84	7	7	NUM
bam-5830	755	85	boncompagni	boncompagni	NOUN
bam-5830	755	86	s.	s.	PROPN
bam-5830	755	87	14,17,17,18	14,17,17,18	NUM
bam-5830	755	88	bono	bono	X
bam-5830	755	89	f.	f.	PROPN
bam-5830	755	90	12	12	NUM
bam-5830	755	91	bouche	bouche	PROPN
bam-5830	755	92	m.	m.	NOUN
bam-5830	755	93	13	13	NUM
bam-5830	755	94	bozzoni	bozzoni	PROPN
bam-5830	755	95	i.	i.	PROPN
bam-5830	755	96	16,20	16,20	PROPN
bam-5830	755	97	braga	braga	PROPN
bam-5830	755	98	a.	a.	PROPN
bam-5830	755	99	14	14	NUM
bam-5830	755	100	braga	braga	PROPN
bam-5830	755	101	a.	a.	NOUN
bam-5830	755	102	14	14	NUM
bam-5830	755	103	braghetta	braghetta	NOUN
bam-5830	756	1	p.	p.	NOUN
bam-5830	756	2	15	15	NUM
bam-5830	757	1	briganti	briganti	PROPN
bam-5830	757	2	f.	f.	PROPN
bam-5830	757	3	16	16	PROPN
bam-5830	757	4	bruzzone	bruzzone	PROPN
bam-5830	757	5	e.	e.	PROPN
bam-5830	757	6	8	8	PROPN
bam-5830	757	7	buckingham	buckingham	PROPN
bam-5830	757	8	m.	m.	NOUN
bam-5830	757	9	3	3	NUM
bam-5830	757	10	buttgereit	buttgereit	PROPN
bam-5830	757	11	a.	a.	NOUN
bam-5830	757	12	13	13	NUM
bam-5830	757	13	cabianca	cabianca	PROPN
bam-5830	757	14	d.	d.	PROPN
bam-5830	757	15	s.	s.	PROPN
bam-5830	757	16	22	22	NUM
bam-5830	757	17	caccia	caccia	PROPN
bam-5830	757	18	r	r	NOUN
bam-5830	757	19	20	20	NUM
bam-5830	757	20	cagnin	cagnin	NOUN
bam-5830	757	21	s.	s.	PROPN
bam-5830	757	22	14	14	NUM
bam-5830	757	23	camps	camp	NOUN
bam-5830	757	24	j.	j.	PROPN
bam-5830	757	25	19	19	NUM
bam-5830	757	26	canato	canato	NOUN
bam-5830	757	27	m.	m.	NOUN
bam-5830	757	28	17	17	NUM
bam-5830	757	29	cannata	cannata	NOUN
bam-5830	757	30	s	s	PART
bam-5830	757	31	16	16	NUM
bam-5830	757	32	canton	canton	PROPN
bam-5830	757	33	m.	m.	NOUN
bam-5830	757	34	8	8	NUM
bam-5830	757	35	caremani	caremani	PROPN
bam-5830	757	36	m.	m.	NOUN
bam-5830	757	37	15	15	NUM
bam-5830	757	38	carotenuto	carotenuto	PROPN
bam-5830	757	39	f.	f.	PROPN
bam-5830	757	40	19	19	NUM
bam-5830	757	41	carullo	carullo	PROPN
bam-5830	757	42	p.	p.	NOUN
bam-5830	757	43	15	15	NUM
bam-5830	757	44	castagnaro	castagnaro	NOUN
bam-5830	757	45	s.	s.	PROPN
bam-5830	757	46	15	15	NUM
bam-5830	757	47	spizzotin	spizzotin	PROPN
bam-5830	757	48	m.	m.	NOUN
bam-5830	757	49	15	15	NUM
bam-5830	757	50	castagnoli	castagnoli	NOUN
bam-5830	757	51	l.	l.	PROPN
bam-5830	758	1	4,6,12,14	4,6,12,14	NUM
bam-5830	758	2	castiglioni	castiglioni	PROPN
bam-5830	758	3	i.	i.	PROPN
bam-5830	758	4	20	20	NUM
bam-5830	758	5	cecconi	cecconi	PROPN
bam-5830	758	6	f	f	PROPN
bam-5830	758	7	15	15	NUM
bam-5830	758	8	cerquone	cerquone	NOUN
bam-5830	758	9	perpetuini	perpetuini	PROPN
bam-5830	758	10	a.	a.	PROPN
bam-5830	758	11	14	14	NUM
bam-5830	758	12	cervo	cervo	PROPN
bam-5830	758	13	l.	l.	PROPN
bam-5830	758	14	10	10	NUM
bam-5830	758	15	cesareni	cesareni	PROPN
bam-5830	758	16	g.	g.	PROPN
bam-5830	758	17	4,6	4,6	PROPN
bam-5830	758	18	,	,	PUNCT
bam-5830	758	19	12,14,16	12,14,16	NUM
bam-5830	758	20	cescon	cescon	NOUN
bam-5830	758	21	m.	m.	NOUN
bam-5830	758	22	20	20	NUM
bam-5830	758	23	chemello	chemello	NOUN
bam-5830	758	24	f	f	PROPN
bam-5830	758	25	14	14	NUM
bam-5830	758	26	chen	chen	PROPN
bam-5830	758	27	j.	j.	PROPN
bam-5830	758	28	15	15	NUM
bam-5830	758	29	chiappalupi	chiappalupi	PROPN
bam-5830	758	30	s.	s.	PROPN
bam-5830	758	31	18	18	NUM
bam-5830	758	32	chiarelli	chiarelli	PROPN
bam-5830	758	33	n.	n.	PROPN
bam-5830	758	34	12,13	12,13	PROPN
bam-5830	758	35	chrisam	chrisam	PROPN
bam-5830	758	36	m.	m.	NOUN
bam-5830	758	37	15	15	NUM
bam-5830	758	38	cipriano	cipriano	PROPN
bam-5830	758	39	a.	a.	PROPN
bam-5830	758	40	20	20	NUM
bam-5830	758	41	clementi	clementi	PROPN
bam-5830	758	42	e.	e.	PROPN
bam-5830	758	43	11	11	PROPN
bam-5830	758	44	codenotti	codenotti	PROPN
bam-5830	758	45	s.	s.	PROPN
bam-5830	758	46	12	12	NUM
bam-5830	758	47	coggi	coggi	PROPN
bam-5830	758	48	a.	a.	PROPN
bam-5830	758	49	16	16	PROPN
bam-5830	758	50	colombi	colombi	PROPN
bam-5830	758	51	m.	m.	PROPN
bam-5830	758	52	12,13	12,13	NUM
bam-5830	758	53	cominelli	cominelli	PROPN
bam-5830	758	54	m.	m.	NOUN
bam-5830	758	55	12	12	NUM
bam-5830	758	56	consalvi	consalvi	PROPN
bam-5830	758	57	s.	s.	PROPN
bam-5830	758	58	3,20,21	3,20,21	NUM
bam-5830	758	59	conte	conte	PROPN
bam-5830	758	60	m.	m.	NOUN
bam-5830	758	61	12	12	NUM
bam-5830	758	62	cooke	cooke	PROPN
bam-5830	758	63	r.	r.	PROPN
bam-5830	758	64	7	7	PROPN
bam-5830	759	1	coslovich	coslovich	PROPN
bam-5830	759	2	t.	t.	PROPN
bam-5830	759	3	6	6	NUM
bam-5830	759	4	costamagna	costamagna	PROPN
bam-5830	759	5	d.	d.	PROPN
bam-5830	759	6	9	9	NUM
bam-5830	759	7	costelli	costelli	ADV
bam-5830	760	1	p.	p.	PROPN
bam-5830	760	2	8,9,10	8,9,10	PROPN
bam-5830	760	3	d’onofrio	d’onofrio	PROPN
bam-5830	760	4	l.	l.	PROPN
bam-5830	760	5	18	18	NUM
bam-5830	760	6	de	de	X
bam-5830	760	7	feo	feo	X
bam-5830	760	8	l.	l.	PROPN
bam-5830	760	9	3	3	PROPN
bam-5830	760	10	de	de	PROPN
bam-5830	760	11	marco	marco	PROPN
bam-5830	760	12	a.	a.	PROPN
bam-5830	760	13	17	17	NUM
bam-5830	760	14	de	de	PROPN
bam-5830	760	15	santa	santa	PROPN
bam-5830	760	16	f.	f.	PROPN
bam-5830	760	17	17	17	NUM
bam-5830	760	18	de	de	PROPN
bam-5830	760	19	stefani	stefani	PROPN
bam-5830	760	20	d.	d.	PROPN
bam-5830	760	21	14	14	NUM
bam-5830	760	22	del	del	PROPN
bam-5830	760	23	prete	prete	PROPN
bam-5830	760	24	z.	z.	PROPN
bam-5830	760	25	7	7	NUM
bam-5830	760	26	del	del	PROPN
bam-5830	760	27	re	re	PROPN
bam-5830	760	28	v.	v.	PROPN
bam-5830	760	29	21	21	NUM
bam-5830	760	30	depalma	depalma	PROPN
bam-5830	760	31	c.	c.	PROPN
bam-5830	760	32	11	11	NUM
bam-5830	760	33	desiderio	desiderio	NOUN
bam-5830	760	34	g.	g.	PROPN
bam-5830	760	35	14	14	NUM
bam-5830	760	36	di	di	PROPN
bam-5830	760	37	filippo	filippo	PROPN
bam-5830	760	38	e.s	e.s	PROPN
bam-5830	760	39	4	4	NUM
bam-5830	760	40	di	di	NOUN
bam-5830	760	41	fonso	fonso	PROPN
bam-5830	760	42	a.	a.	PROPN
bam-5830	760	43	18	18	NUM
bam-5830	760	44	di	di	NOUN
bam-5830	760	45	francescantonio	francescantonio	PROPN
bam-5830	760	46	s.	s.	PROPN
bam-5830	760	47	3	3	NUM
bam-5830	760	48	di	di	PROPN
bam-5830	760	49	nardo	nardo	PROPN
bam-5830	760	50	p.	p.	PROPN
bam-5830	760	51	19	19	NUM
bam-5830	760	52	di	di	NOUN
bam-5830	760	53	timoteo	timoteo	NOUN
bam-5830	760	54	g.	g.	PROPN
bam-5830	760	55	16	16	NUM
bam-5830	760	56	dirksen	dirksen	PROPN
bam-5830	760	57	r.t	r.t	PROPN
bam-5830	760	58	.	.	PROPN
bam-5830	760	59	7	7	NUM
bam-5830	760	60	dobrowolny	dobrowolny	PROPN
bam-5830	760	61	g.	g.	PROPN
bam-5830	760	62	21	21	NUM
bam-5830	760	63	dolfini	dolfini	PROPN
bam-5830	760	64	d.	d.	PROPN
bam-5830	760	65	4	4	NUM
bam-5830	760	66	donato	donato	PROPN
bam-5830	760	67	r.	r.	PROPN
bam-5830	761	1	3,18	3,18	PROPN
bam-5830	762	1	eiber	eiber	PROPN
bam-5830	762	2	n.	n.	NOUN
bam-5830	762	3	13	13	NUM
bam-5830	762	4	elvassore	elvassore	NOUN
bam-5830	762	5	n.	n.	NOUN
bam-5830	762	6	5	5	NUM
bam-5830	762	7	faggi	faggi	ADJ
bam-5830	762	8	f.	f.	PROPN
bam-5830	762	9	12	12	NUM
bam-5830	762	10	faggi	faggi	ADJ
bam-5830	762	11	f.	f.	PROPN
bam-5830	762	12	13	13	NUM
bam-5830	762	13	fanzani	fanzani	PROPN
bam-5830	762	14	a.	a.	PROPN
bam-5830	762	15	12,13	12,13	PROPN
bam-5830	762	16	fatica	fatica	PROPN
bam-5830	762	17	a.	a.	PROPN
bam-5830	762	18	16	16	NUM
bam-5830	763	1	ferri	ferri	PROPN
bam-5830	763	2	g.	g.	PROPN
bam-5830	763	3	22	22	NUM
bam-5830	763	4	filomena	filomena	PROPN
bam-5830	763	5	m.c	m.c	PROPN
bam-5830	763	6	.	.	PROPN
bam-5830	763	7	15	15	NUM
bam-5830	763	8	fiorentini	fiorentini	PROPN
bam-5830	763	9	c.	c.	PROPN
bam-5830	763	10	12	12	NUM
bam-5830	763	11	forcina	forcina	PROPN
bam-5830	763	12	l.	l.	PROPN
bam-5830	763	13	16	16	NUM
bam-5830	763	14	franceschi	franceschi	PROPN
bam-5830	763	15	c.	c.	PROPN
bam-5830	763	16	12	12	NUM
bam-5830	763	17	frati	frati	PROPN
bam-5830	763	18	a.	a.	NOUN
bam-5830	763	19	8	8	NUM
bam-5830	764	1	friedrich	friedrich	NOUN
bam-5830	764	2	o.	o.	NOUN
bam-5830	764	3	13	13	NUM
bam-5830	764	4	fulle	fulle	ADJ
bam-5830	764	5	s.	s.	PROPN
bam-5830	764	6	4	4	NUM
bam-5830	764	7	fuoco	fuoco	PROPN
bam-5830	764	8	c.	c.	PROPN
bam-5830	764	9	4,12,14,16	4,12,14,16	PROPN
bam-5830	764	10	gabellini	gabellini	PROPN
bam-5830	764	11	d.	d.	PROPN
bam-5830	764	12	20,22	20,22	NUM
bam-5830	764	13	gamberucci	gamberucci	PROPN
bam-5830	764	14	a.	a.	PROPN
bam-5830	764	15	21	21	NUM
bam-5830	764	16	ganassi	ganassi	PROPN
bam-5830	764	17	m.	m.	NOUN
bam-5830	764	18	3	3	NUM
bam-5830	764	19	gargioli	gargioli	PROPN
bam-5830	764	20	c.	c.	PROPN
bam-5830	764	21	12,14	12,14	PROPN
bam-5830	764	22	gargioli	gargioli	PROPN
bam-5830	764	23	c.	c.	PROPN
bam-5830	764	24	4,6	4,6	PROPN
bam-5830	764	25	gargioli	gargioli	PROPN
bam-5830	764	26	c.	c.	PROPN
bam-5830	764	27	16	16	NUM
bam-5830	765	1	gattazzo	gattazzo	PROPN
bam-5830	765	2	f.	f.	PROPN
bam-5830	765	3	20	20	NUM
bam-5830	765	4	gavazzi	gavazzi	PROPN
bam-5830	765	5	s.	s.	PROPN
bam-5830	765	6	12	12	NUM
bam-5830	765	7	gawor	gawor	NOUN
bam-5830	765	8	m.	m.	NOUN
bam-5830	765	9	7	7	NUM
bam-5830	765	10	gherardi	gherardi	NOUN
bam-5830	765	11	g.	g.	NOUN
bam-5830	765	12	14	14	NUM
bam-5830	765	13	giacomazzi	giacomazzi	PROPN
bam-5830	765	14	g.	g.	PROPN
bam-5830	765	15	5	5	NUM
bam-5830	765	16	giambruno	giambruno	PROPN
bam-5830	765	17	r.	r.	PROPN
bam-5830	765	18	22	22	NUM
bam-5830	765	19	giavazzi	giavazzi	PROPN
bam-5830	765	20	r.	r.	PROPN
bam-5830	765	21	10	10	NUM
bam-5830	765	22	gicquel	gicquel	PROPN
bam-5830	765	23	e.	e.	PROPN
bam-5830	765	24	22	22	PROPN
bam-5830	765	25	giordani	giordani	PROPN
bam-5830	765	26	l.	l.	PROPN
bam-5830	765	27	4	4	NUM
bam-5830	765	28	giovarelli	giovarelli	PROPN
bam-5830	765	29	m	m	VERB
bam-5830	765	30	11	11	NUM
bam-5830	765	31	giulitti	giulitti	ADJ
bam-5830	765	32	s.	s.	PROPN
bam-5830	765	33	5	5	NUM
bam-5830	765	34	grumati	grumati	NOUN
bam-5830	765	35	p.	p.	NOUN
bam-5830	765	36	15	15	NUM
bam-5830	766	1	guarnieri	guarnieri	PROPN
bam-5830	766	2	s.	s.	PROPN
bam-5830	766	3	4	4	NUM
bam-5830	766	4	guescini	guescini	PROPN
bam-5830	766	5	m.	m.	NOUN
bam-5830	766	6	15	15	NUM
bam-5830	766	7	guido	guido	NOUN
bam-5830	766	8	l.	l.	PROPN
bam-5830	766	9	20	20	NUM
bam-5830	766	10	guttridge	guttridge	PROPN
bam-5830	766	11	d.c	d.c	PROPN
bam-5830	766	12	.	.	PROPN
bam-5830	766	13	10	10	NUM
bam-5830	766	14	hamilton	hamilton	PROPN
bam-5830	766	15	s.	s.	PROPN
bam-5830	766	16	l.	l.	PROPN
bam-5830	766	17	17,17	17,17	PROPN
bam-5830	766	18	harbauer	harbauer	PROPN
bam-5830	766	19	a.	a.	PROPN
bam-5830	766	20	b.	b.	PROPN
bam-5830	766	21	13	13	NUM
bam-5830	766	22	hashemolhosseini	hashemolhosseini	ADJ
bam-5830	766	23	s.	s.	PROPN
bam-5830	766	24	13	13	NUM
bam-5830	766	25	hashemolhosseini	hashemolhosseini	ADJ
bam-5830	766	26	s.	s.	PROPN
bam-5830	766	27	13,20	13,20	PROPN
bam-5830	766	28	heuss	heuss	PROPN
bam-5830	766	29	d.	d.	PROPN
bam-5830	766	30	13	13	NUM
bam-5830	766	31	huber	huber	PROPN
bam-5830	766	32	j.	j.	PROPN
bam-5830	766	33	22	22	PROPN
bam-5830	766	34	huraskin	huraskin	VERB
bam-5830	766	35	d.	d.	PROPN
bam-5830	766	36	13	13	NUM
bam-5830	766	37	imbriano	imbriano	PROPN
bam-5830	766	38	c.	c.	PROPN
bam-5830	766	39	3,4	3,4	NUM
bam-5830	766	40	jolanta	jolanta	PROPN
bam-5830	766	41	rędowicz	rędowicz	VERB
bam-5830	766	42	m	m	PROPN
bam-5830	766	43	7	7	NUM
bam-5830	766	44	jothi	jothi	ADJ
bam-5830	766	45	m.	m.	NOUN
bam-5830	766	46	22	22	NUM
bam-5830	766	47	jóźwiak	jóźwiak	PROPN
bam-5830	766	48	j.	j.	PROPN
bam-5830	766	49	7	7	PROPN
bam-5830	766	50	kaiser	kaiser	PROPN
bam-5830	766	51	t.	t.	PROPN
bam-5830	766	52	13	13	NUM
bam-5830	766	53	keller	keller	PROPN
bam-5830	766	54	c.	c.	PROPN
bam-5830	766	55	13	13	NUM
bam-5830	766	56	kellerd	kellerd	NOUN
bam-5830	766	57	c.	c.	PROPN
bam-5830	766	58	12	12	NUM
bam-5830	767	1	kravic	kravic	PROPN
bam-5830	767	2	b.	b.	PROPN
bam-5830	767	3	13,13	13,13	PROPN
bam-5830	767	4	lahm	lahm	PROPN
bam-5830	767	5	a.	a.	PROPN
bam-5830	767	6	20	20	NUM
bam-5830	767	7	lanfranchi	lanfranchi	PROPN
bam-5830	767	8	g	g	PROPN
bam-5830	767	9	14	14	NUM
bam-5830	767	10	le	le	PROPN
bam-5830	767	11	grand	grand	PROPN
bam-5830	767	12	f.	f.	PROPN
bam-5830	767	13	4	4	NUM
bam-5830	767	14	lecker	lecker	PROPN
bam-5830	767	15	s.h	s.h	PROPN
bam-5830	767	16	.	.	PROPN
bam-5830	767	17	10	10	NUM
bam-5830	767	18	legnini	legnini	PROPN
bam-5830	767	19	i.	i.	PROPN
bam-5830	767	20	16	16	PROPN
bam-5830	767	21	lieber	lieber	PROPN
bam-5830	767	22	r.	r.	PROPN
bam-5830	767	23	15	15	NUM
bam-5830	767	24	linari	linari	PROPN
bam-5830	767	25	m.	m.	NOUN
bam-5830	767	26	15	15	NUM
bam-5830	767	27	lo	lo	PROPN
bam-5830	767	28	h.	h.	PROPN
bam-5830	767	29	p.	p.	NOUN
bam-5830	767	30	12	12	NUM
bam-5830	768	1	lo	lo	PROPN
bam-5830	768	2	verso	verso	PROPN
bam-5830	768	3	f.	f.	PROPN
bam-5830	768	4	15	15	NUM
bam-5830	768	5	longhena	longhena	PROPN
bam-5830	768	6	f.	f.	PROPN
bam-5830	768	7	13	13	NUM
bam-5830	769	1	lorenzon	lorenzon	NOUN
bam-5830	769	2	p.	p.	NOUN
bam-5830	769	3	6	6	NUM
bam-5830	770	1	lutz	lutz	PROPN
bam-5830	770	2	c.	c.	PROPN
bam-5830	770	3	11	11	NUM
bam-5830	770	4	madaro	madaro	NOUN
bam-5830	770	5	l.	l.	NOUN
bam-5830	770	6	9,13	9,13	NUM
bam-5830	770	7	madaro	madaro	NOUN
bam-5830	770	8	l.	l.	NOUN
bam-5830	770	9	17	17	NUM
bam-5830	770	10	madaro	madaro	NOUN
bam-5830	770	11	l.	l.	PROPN
bam-5830	770	12	20	20	NUM
bam-5830	770	13	maggi	maggi	PROPN
bam-5830	770	14	d.	d.	PROPN
bam-5830	770	15	13	13	NUM
bam-5830	770	16	mammucari	mammucari	PROPN
bam-5830	770	17	c.	c.	PROPN
bam-5830	770	18	14,14	14,14	PROPN
bam-5830	770	19	mancinelli	mancinelli	PROPN
bam-5830	770	20	r.	r.	PROPN
bam-5830	770	21	4	4	NUM
bam-5830	770	22	mancinelli	mancinelli	PROPN
bam-5830	770	23	r.	r.	PROPN
bam-5830	770	24	19	19	NUM
bam-5830	770	25	mantovani	mantovani	PROPN
bam-5830	770	26	r.	r.	PROPN
bam-5830	770	27	4	4	NUM
bam-5830	770	28	marcucci	marcucci	PROPN
bam-5830	770	29	l.	l.	PROPN
bam-5830	770	30	6	6	NUM
bam-5830	770	31	marinkovic	marinkovic	ADJ
bam-5830	770	32	m.	m.	NOUN
bam-5830	770	33	6	6	NUM
bam-5830	770	34	marroncelli	marroncelli	PROPN
bam-5830	770	35	n.	n.	PROPN
bam-5830	770	36	3	3	NUM
bam-5830	770	37	marsolier	marsolier	ADV
bam-5830	770	38	j.	j.	PROPN
bam-5830	770	39	22	22	NUM
bam-5830	770	40	martinelli	martinelli	PROPN
bam-5830	770	41	g.b	g.b	PROPN
bam-5830	770	42	.	.	PROPN
bam-5830	770	43	10	10	NUM
bam-5830	770	44	martini	martini	NOUN
bam-5830	770	45	m.	m.	NOUN
bam-5830	770	46	21	21	NUM
bam-5830	770	47	mastrototaro	mastrototaro	NOUN
bam-5830	770	48	g.	g.	NOUN
bam-5830	770	49	15	15	NUM
bam-5830	770	50	mattei	mattei	NOUN
bam-5830	770	51	n.	n.	NOUN
bam-5830	770	52	5	5	NUM
bam-5830	770	53	matteini	matteini	PROPN
bam-5830	770	54	f.	f.	PROPN
bam-5830	770	55	8	8	NUM
bam-5830	770	56	meacci	meacci	PROPN
bam-5830	770	57	e.	e.	PROPN
bam-5830	770	58	8	8	NUM
bam-5830	770	59	megighian	megighian	PROPN
bam-5830	770	60	a.	a.	NOUN
bam-5830	770	61	20	20	NUM
bam-5830	770	62	meisinger	meisinger	NOUN
bam-5830	770	63	c.	c.	PROPN
bam-5830	770	64	13	13	NUM
bam-5830	770	65	micheloni	micheloni	PROPN
bam-5830	770	66	s.	s.	PROPN
bam-5830	770	67	22	22	NUM
bam-5830	770	68	michelucci	michelucci	PROPN
bam-5830	770	69	a.	a.	NOUN
bam-5830	770	70	7,17,18	7,17,18	NUM
bam-5830	770	71	michelucci	michelucci	VERB
bam-5830	770	72	a.	a.	NOUN
bam-5830	770	73	17	17	NUM
bam-5830	770	74	minieri	minieri	PROPN
bam-5830	770	75	m.	m.	NOUN
bam-5830	770	76	19	19	NUM
bam-5830	770	77	mitola	mitola	PROPN
bam-5830	770	78	s.	s.	PROPN
bam-5830	770	79	13	13	NUM
bam-5830	770	80	molinari	molinari	PROPN
bam-5830	770	81	s.	s.	PROPN
bam-5830	770	82	3,4	3,4	NUM
bam-5830	770	83	montarras	montarras	X
bam-5830	770	84	d.	d.	PROPN
bam-5830	770	85	3	3	NUM
bam-5830	770	86	monti	monti	PROPN
bam-5830	770	87	e.	e.	PROPN
bam-5830	770	88	12,13	12,13	PROPN
bam-5830	770	89	moresi	moresi	X
bam-5830	770	90	v.	v.	ADP
bam-5830	770	91	3	3	NUM
bam-5830	770	92	moresi	moresi	NOUN
bam-5830	770	93	v.	v.	ADP
bam-5830	770	94	19	19	NUM
bam-5830	770	95	abstracts	abstract	NOUN
bam-5830	770	96	of	of	ADP
bam-5830	770	97	the	the	DET
bam-5830	770	98	xii	xii	PROPN
bam-5830	770	99	iim	iim	NOUN
bam-5830	770	100	myology	myology	NOUN
bam-5830	770	101	meeting	meet	VERB
bam-5830	770	102	1	1	NUM
bam-5830	770	103	-	-	SYM
bam-5830	770	104	4	4	NUM
bam-5830	770	105	october	october	NOUN
bam-5830	770	106	2015	2015	NUM
bam-5830	770	107	eur	eur	PROPN
bam-5830	770	108	j	j	PROPN
bam-5830	770	109	transl	transl	PROPN
bam-5830	770	110	myol	myol	PROPN
bam-5830	770	111	basic	basic	ADJ
bam-5830	770	112	appl	appl	NOUN
bam-5830	770	113	myol	myol	NOUN
bam-5830	770	114	2016	2016	NUM
bam-5830	770	115	;	;	PUNCT
bam-5830	770	116	26	26	NUM
bam-5830	770	117	(	(	PUNCT
bam-5830	770	118	1	1	NUM
bam-5830	770	119	):	):	PUNCT
bam-5830	770	120	2	2	NUM
bam-5830	770	121	-	-	SYM
bam-5830	770	122	24	24	NUM
bam-5830	770	123	this	this	DET
bam-5830	770	124	article	article	NOUN
bam-5830	770	125	is	be	AUX
bam-5830	770	126	distributed	distribute	VERB
bam-5830	770	127	under	under	ADP
bam-5830	770	128	the	the	DET
bam-5830	770	129	terms	term	NOUN
bam-5830	770	130	of	of	ADP
bam-5830	770	131	the	the	DET
bam-5830	770	132	creative	creative	ADJ
bam-5830	770	133	commons	common	NOUN
bam-5830	770	134	attribution	attribution	NOUN
bam-5830	770	135	noncommercial	noncommercial	ADJ
bam-5830	770	136	license	license	NOUN
bam-5830	770	137	(	(	PUNCT
bam-5830	770	138	cc	cc	NOUN
bam-5830	770	139	by	by	ADP
bam-5830	770	140	-	-	PUNCT
bam-5830	770	141	nc	nc	PROPN
bam-5830	770	142	4.0	4.0	NUM
bam-5830	770	143	)	)	PUNCT
bam-5830	770	144	which	which	PRON
bam-5830	770	145	permits	permit	VERB
bam-5830	770	146	any	any	DET
bam-5830	770	147	noncommercial	noncommercial	ADJ
bam-5830	770	148	use	use	NOUN
bam-5830	770	149	,	,	PUNCT
bam-5830	770	150	distribution	distribution	NOUN
bam-5830	770	151	,	,	PUNCT
bam-5830	770	152	and	and	CCONJ
bam-5830	770	153	reproduction	reproduction	NOUN
bam-5830	770	154	in	in	ADP
bam-5830	770	155	any	any	DET
bam-5830	770	156	medium	medium	NOUN
bam-5830	770	157	,	,	PUNCT
bam-5830	770	158	provided	provide	VERB
bam-5830	770	159	the	the	DET
bam-5830	770	160	original	original	ADJ
bam-5830	770	161	author(s	author(s	NOUN
bam-5830	770	162	)	)	PUNCT
bam-5830	770	163	and	and	CCONJ
bam-5830	770	164	source	source	NOUN
bam-5830	770	165	are	be	AUX
bam-5830	770	166	credited	credit	VERB
bam-5830	770	167	.	.	PUNCT
bam-5830	771	1	24	24	NUM
bam-5830	771	2	morlando	morlando	NOUN
bam-5830	771	3	m.	m.	NOUN
bam-5830	771	4	16	16	NUM
bam-5830	771	5	musarò	musarò	ADV
bam-5830	771	6	a.	a.	NOUN
bam-5830	771	7	3,7,16,21	3,7,16,21	PROPN
bam-5830	771	8	naber	naber	PROPN
bam-5830	771	9	n.	n.	PROPN
bam-5830	771	10	8	8	PROPN
bam-5830	771	11	neuhuber	neuhuber	PROPN
bam-5830	771	12	w.	w.	PROPN
bam-5830	771	13	34	34	NUM
bam-5830	771	14	nicoletti	nicoletti	PROPN
bam-5830	771	15	c.	c.	PROPN
bam-5830	771	16	3	3	NUM
bam-5830	771	17	niewiadomski	niewiadomski	NOUN
bam-5830	771	18	p	p	ADJ
bam-5830	771	19	7	7	NUM
bam-5830	771	20	nigro	nigro	NOUN
bam-5830	771	21	v.	v.	ADP
bam-5830	771	22	15	15	NUM
bam-5830	771	23	nogara	nogara	NOUN
bam-5830	772	1	l.	l.	PROPN
bam-5830	772	2	8	8	NUM
bam-5830	772	3	noviello	noviello	PROPN
bam-5830	772	4	c.	c.	PROPN
bam-5830	772	5	3	3	NUM
bam-5830	772	6	olivari	olivari	PROPN
bam-5830	772	7	d.	d.	PROPN
bam-5830	772	8	10	10	NUM
bam-5830	773	1	olson	olson	PROPN
bam-5830	773	2	e.	e.	PROPN
bam-5830	773	3	n.	n.	PROPN
bam-5830	773	4	3	3	NUM
bam-5830	773	5	ottoboni	ottoboni	PROPN
bam-5830	773	6	l.	l.	PROPN
bam-5830	773	7	10	10	NUM
bam-5830	773	8	pallafacchina	pallafacchina	PROPN
bam-5830	773	9	g.	g.	PROPN
bam-5830	773	10	14	14	NUM
bam-5830	774	1	paolini	paolini	PROPN
bam-5830	774	2	c.	c.	PROPN
bam-5830	774	3	17	17	NUM
bam-5830	774	4	paoluzi	paoluzi	PROPN
bam-5830	774	5	s.	s.	PROPN
bam-5830	774	6	4	4	NUM
bam-5830	774	7	parton	parton	PROPN
bam-5830	774	8	r.	r.	PROPN
bam-5830	774	9	g.	g.	PROPN
bam-5830	774	10	12	12	NUM
bam-5830	774	11	passafaro	passafaro	NOUN
bam-5830	774	12	m.	m.	NOUN
bam-5830	774	13	9	9	NUM
bam-5830	774	14	pate	pate	NOUN
bam-5830	774	15	e.	e.	PROPN
bam-5830	774	16	8	8	PROPN
bam-5830	774	17	patissier	patissier	PROPN
bam-5830	774	18	c.	c.	PROPN
bam-5830	774	19	22	22	NUM
bam-5830	774	20	pavlidou	pavlidou	NOUN
bam-5830	774	21	t.	t.	NOUN
bam-5830	774	22	6	6	NUM
bam-5830	774	23	pelosi	pelosi	PROPN
bam-5830	774	24	l.	l.	PROPN
bam-5830	774	25	16	16	NUM
bam-5830	774	26	penna	penna	PROPN
bam-5830	774	27	f.	f.	PROPN
bam-5830	774	28	8,9,10	8,9,10	PROPN
bam-5830	774	29	pescatore	pescatore	PROPN
bam-5830	774	30	f.	f.	PROPN
bam-5830	774	31	11	11	NUM
bam-5830	774	32	petrilli	petrilli	PROPN
bam-5830	774	33	l.l	l.l	PROPN
bam-5830	774	34	12,16	12,16	PROPN
bam-5830	774	35	piccirillo	piccirillo	PROPN
bam-5830	774	36	r.	r.	PROPN
bam-5830	774	37	10	10	NUM
bam-5830	774	38	pierucci	pierucci	PROPN
bam-5830	774	39	f.	f.	PROPN
bam-5830	774	40	8	8	NUM
bam-5830	774	41	pietrangelo	pietrangelo	PROPN
bam-5830	774	42	l.	l.	PROPN
bam-5830	774	43	7	7	NUM
bam-5830	774	44	pietrangelo	pietrangelo	PROPN
bam-5830	774	45	t	t	PROPN
bam-5830	774	46	4	4	NUM
bam-5830	774	47	pigna	pigna	NOUN
bam-5830	774	48	e	e	NOUN
bam-5830	774	49	19	19	NUM
bam-5830	774	50	pin	pin	NOUN
bam-5830	774	51	f.	f.	PROPN
bam-5830	774	52	9	9	NUM
bam-5830	774	53	pin	pin	PROPN
bam-5830	774	54	f.	f.	PROPN
bam-5830	774	55	10	10	NUM
bam-5830	774	56	pirrò	pirrò	PROPN
bam-5830	774	57	s.	s.	PROPN
bam-5830	774	58	4	4	NUM
bam-5830	774	59	pisu	pisu	NOUN
bam-5830	774	60	s.	s.	PROPN
bam-5830	774	61	7	7	NUM
bam-5830	775	1	poliani	poliani	PROPN
bam-5830	775	2	l.	l.	PROPN
bam-5830	775	3	13	13	NUM
bam-5830	776	1	poliani	poliani	PROPN
bam-5830	776	2	p.	p.	NOUN
bam-5830	776	3	l.	l.	NOUN
bam-5830	777	1	12	12	NUM
bam-5830	777	2	prószyński	prószyński	NOUN
bam-5830	777	3	t.	t.	PROPN
bam-5830	777	4	7	7	NUM
bam-5830	777	5	protasi	protasi	PROPN
bam-5830	777	6	f.	f.	PROPN
bam-5830	777	7	7,14,17,17,18	7,14,17,17,18	PROPN
bam-5830	778	1	puri	puri	PROPN
bam-5830	778	2	p.l	p.l	PROPN
bam-5830	778	3	.	.	PUNCT
bam-5830	779	1	3,9,20,21	3,9,20,21	NUM
bam-5830	779	2	quattrocelli	quattrocelli	PROPN
bam-5830	779	3	m.	m.	NOUN
bam-5830	779	4	5,19	5,19	PROPN
bam-5830	779	5	raffaello	raffaello	PROPN
bam-5830	779	6	a.	a.	PROPN
bam-5830	779	7	14	14	NUM
bam-5830	779	8	rajewsky	rajewsky	PROPN
bam-5830	779	9	n.	n.	PROPN
bam-5830	779	10	16	16	NUM
bam-5830	779	11	reggiani	reggiani	PROPN
bam-5830	779	12	c.	c.	PROPN
bam-5830	779	13	8,17	8,17	NUM
bam-5830	779	14	reggio	reggio	PROPN
bam-5830	779	15	a.	a.	PROPN
bam-5830	779	16	4	4	PROPN
bam-5830	779	17	reichel	reichel	PROPN
bam-5830	779	18	m.	m.	PROPN
bam-5830	779	19	13	13	NUM
bam-5830	779	20	resovi	resovi	PROPN
bam-5830	779	21	a.	a.	NOUN
bam-5830	779	22	9	9	NUM
bam-5830	779	23	ricci	ricci	PROPN
bam-5830	779	24	l.	l.	PROPN
bam-5830	779	25	4	4	NUM
bam-5830	779	26	richard	richard	PROPN
bam-5830	779	27	i.	i.	PROPN
bam-5830	779	28	22	22	NUM
bam-5830	779	29	riuzzi	riuzzi	NOUN
bam-5830	779	30	f.	f.	PROPN
bam-5830	779	31	3	3	PROPN
bam-5830	779	32	rizzuto	rizzuto	PROPN
bam-5830	779	33	e.	e.	PROPN
bam-5830	779	34	7	7	PROPN
bam-5830	779	35	rizzuto	rizzuto	PROPN
bam-5830	779	36	r	r	NOUN
bam-5830	779	37	14,14	14,14	NUM
bam-5830	779	38	rojek	rojek	VERB
bam-5830	779	39	k.	k.	PROPN
bam-5830	779	40	7	7	NUM
bam-5830	779	41	romanello	romanello	ADV
bam-5830	779	42	v.	v.	ADP
bam-5830	779	43	13	13	NUM
bam-5830	779	44	ronca	ronca	PROPN
bam-5830	779	45	r.	r.	PROPN
bam-5830	779	46	13	13	NUM
bam-5830	779	47	rossi	rossi	PROPN
bam-5830	779	48	f.	f.	PROPN
bam-5830	779	49	16	16	NUM
bam-5830	779	50	rudolf	rudolf	PROPN
bam-5830	779	51	r.	r.	PROPN
bam-5830	779	52	13	13	NUM
bam-5830	779	53	sabatelli	sabatelli	PROPN
bam-5830	780	1	p.	p.	NOUN
bam-5830	780	2	20	20	NUM
bam-5830	780	3	saccone	saccone	NOUN
bam-5830	780	4	v.	v.	ADP
bam-5830	780	5	3,20,21	3,20,21	NUM
bam-5830	780	6	sagheddu	sagheddu	ADJ
bam-5830	780	7	r.	r.	PROPN
bam-5830	780	8	18	18	NUM
bam-5830	780	9	salani	salani	PROPN
bam-5830	780	10	b.	b.	PROPN
bam-5830	780	11	13	13	NUM
bam-5830	780	12	salvadori	salvadori	PROPN
bam-5830	780	13	l.	l.	PROPN
bam-5830	780	14	18	18	NUM
bam-5830	780	15	salvioli	salvioli	PROPN
bam-5830	780	16	s.	s.	PROPN
bam-5830	780	17	12	12	NUM
bam-5830	780	18	sampaolesi	sampaolesi	PROPN
bam-5830	780	19	m.	m.	NOUN
bam-5830	780	20	5,19	5,19	PROPN
bam-5830	780	21	sanchez	sanchez	PROPN
bam-5830	780	22	-	-	PUNCT
bam-5830	780	23	riera	riera	PROPN
bam-5830	780	24	c.	c.	PROPN
bam-5830	780	25	20	20	NUM
bam-5830	780	26	sandonà	sandonà	PROPN
bam-5830	780	27	m.	m.	NOUN
bam-5830	780	28	21	21	NUM
bam-5830	780	29	sandri	sandri	ADJ
bam-5830	780	30	m.	m.	NOUN
bam-5830	780	31	11,12,13,14,15	11,12,13,14,15	PROPN
bam-5830	780	32	schiaffino	schiaffino	PROPN
bam-5830	780	33	s.	s.	PROPN
bam-5830	780	34	11	11	NUM
bam-5830	780	35	schirone	schirone	NOUN
bam-5830	780	36	l.	l.	PROPN
bam-5830	780	37	9	9	NUM
bam-5830	780	38	sciancalepore	sciancalepore	ADJ
bam-5830	780	39	m.	m.	NOUN
bam-5830	780	40	6	6	NUM
bam-5830	780	41	selmin	selmin	NOUN
bam-5830	780	42	g.	g.	PROPN
bam-5830	780	43	5	5	NUM
bam-5830	780	44	serena	serena	PROPN
bam-5830	780	45	e.	e.	PROPN
bam-5830	780	46	5	5	NUM
bam-5830	780	47	simeone	simeone	PROPN
bam-5830	780	48	l.	l.	PROPN
bam-5830	780	49	13	13	PROPN
bam-5830	780	50	soares	soares	PROPN
bam-5830	780	51	r.	r.	PROPN
bam-5830	780	52	15	15	NUM
bam-5830	780	53	sorci	sorci	ADJ
bam-5830	780	54	g.	g.	PROPN
bam-5830	780	55	3,18	3,18	NUM
bam-5830	780	56	sorrentino1	sorrentino1	NOUN
bam-5830	780	57	v.	v.	ADP
bam-5830	780	58	21	21	NUM
bam-5830	780	59	spada	spada	PROPN
bam-5830	780	60	f.	f.	PROPN
bam-5830	780	61	2	2	NUM
bam-5830	780	62	spinozzi	spinozzi	NOUN
bam-5830	780	63	s.	s.	PROPN
bam-5830	780	64	21	21	NUM
bam-5830	780	65	sthandier	sthandier	NOUN
bam-5830	780	66	o.	o.	PROPN
bam-5830	780	67	16	16	NUM
bam-5830	780	68	straubinger	straubinger	NOUN
bam-5830	780	69	m.	m.	NOUN
bam-5830	780	70	13	13	NUM
bam-5830	781	1	taccola	taccola	PROPN
bam-5830	781	2	g.	g.	PROPN
bam-5830	781	3	6	6	NUM
bam-5830	781	4	talamini	talamini	PROPN
bam-5830	781	5	l.	l.	PROPN
bam-5830	781	6	10	10	NUM
bam-5830	781	7	testa	testa	PROPN
bam-5830	781	8	s.	s.	PROPN
bam-5830	781	9	16	16	NUM
bam-5830	782	1	tita	tita	PROPN
bam-5830	782	2	r.	r.	PROPN
bam-5830	782	3	20	20	NUM
bam-5830	782	4	torchio	torchio	PROPN
bam-5830	782	5	g.	g.	NOUN
bam-5830	782	6	5	5	NUM
bam-5830	782	7	torcinaro	torcinaro	NOUN
bam-5830	782	8	a.	a.	NOUN
bam-5830	782	9	17	17	NUM
bam-5830	782	10	touvier	touvier	NOUN
bam-5830	782	11	t.	t.	NOUN
bam-5830	782	12	11	11	NUM
bam-5830	782	13	tucciarone	tucciarone	NOUN
bam-5830	782	14	l.	l.	NOUN
bam-5830	782	15	21	21	NUM
bam-5830	782	16	tulipano	tulipano	NOUN
bam-5830	782	17	g.	g.	PROPN
bam-5830	782	18	12	12	NUM
bam-5830	782	19	vetralla	vetralla	NOUN
bam-5830	782	20	m.	m.	NOUN
bam-5830	782	21	5	5	NUM
bam-5830	782	22	vezzoli	vezzoli	PROPN
bam-5830	782	23	m.	m.	NOUN
bam-5830	782	24	12,13	12,13	NUM
bam-5830	782	25	vitiello	vitiello	ADP
bam-5830	782	26	g.	g.	PROPN
bam-5830	782	27	5	5	NUM
bam-5830	782	28	von	von	PROPN
bam-5830	782	29	maltzahn	maltzahn	PROPN
bam-5830	782	30	j.	j.	PROPN
bam-5830	782	31	13	13	PROPN
bam-5830	782	32	wade	wade	PROPN
bam-5830	782	33	m.	m.	PROPN
bam-5830	782	34	16	16	NUM
bam-5830	782	35	warner	warner	PROPN
bam-5830	782	36	s.	s.	PROPN
bam-5830	782	37	22	22	NUM
bam-5830	782	38	washio	washio	PROPN
bam-5830	782	39	t.	t.	PROPN
bam-5830	782	40	6	6	NUM
bam-5830	782	41	yamamoto	yamamoto	PROPN
bam-5830	782	42	d.l	d.l	PROPN
bam-5830	782	43	.	.	PROPN
bam-5830	782	44	16	16	NUM
bam-5830	783	1	yanagida	yanagida	PROPN
bam-5830	783	2	t.	t.	PROPN
bam-5830	783	3	6	6	NUM
bam-5830	783	4	zamparo	zamparo	PROPN
bam-5830	783	5	i.	i.	PROPN
bam-5830	783	6	14	14	NUM
bam-5830	783	7	zanin	zanin	PROPN
bam-5830	783	8	s.	s.	PROPN
bam-5830	783	9	14	14	NUM
bam-5830	783	10	zanola	zanola	PROPN
bam-5830	783	11	a.	a.	NOUN
bam-5830	783	12	12	12	NUM
bam-5830	783	13	zatti	zatti	NOUN
bam-5830	783	14	s.	s.	PROPN
bam-5830	783	15	5	5	NUM
bam-5830	783	16	zentilin	zentilin	PROPN
bam-5830	783	17	l.	l.	PROPN
bam-5830	783	18	14	14	PROPN
bam-5830	783	19	zidek	zidek	PROPN
bam-5830	783	20	l.	l.	PROPN
bam-5830	783	21	13	13	NUM
bam-5830	783	22	ziraldo	ziraldo	PROPN
bam-5830	783	23	g.	g.	PROPN
bam-5830	783	24	6	6	NUM