id	sid	tid	token	lemma	pos
bam-7218	1	1	14	14	NUM
bam-7218	1	2	th	th	NUM
bam-7218	1	3	iiim	iiim	NOUN
bam-7218	1	4	meeting	meeting	NOUN
bam-7218	1	5	,	,	PUNCT
bam-7218	1	6	assisi	assisi	PROPN
bam-7218	1	7	,	,	PUNCT
bam-7218	1	8	italy	italy	PROPN
bam-7218	1	9	october	october	PROPN
bam-7218	1	10	12	12	NUM
bam-7218	1	11	-	-	SYM
bam-7218	1	12	15	15	NUM
bam-7218	1	13	2017	2017	NUM
bam-7218	1	14	eur	eur	PROPN
bam-7218	1	15	j	j	PROPN
bam-7218	1	16	transl	transl	PROPN
bam-7218	1	17	myol	myol	ADV
bam-7218	1	18	27	27	NUM
bam-7218	1	19	(	(	PUNCT
bam-7218	1	20	4	4	NUM
bam-7218	1	21	):	):	SYM
bam-7218	1	22	185	185	NUM
bam-7218	1	23	-	-	SYM
bam-7218	1	24	224	224	NUM
bam-7218	1	25	185	185	NUM
bam-7218	1	26	report	report	NOUN
bam-7218	1	27	and	and	CCONJ
bam-7218	1	28	abstracts	abstract	NOUN
bam-7218	1	29	of	of	ADP
bam-7218	1	30	the	the	DET
bam-7218	1	31	14	14	NUM
bam-7218	1	32	th	th	NOUN
bam-7218	1	33	meeting	meeting	NOUN
bam-7218	1	34	of	of	ADP
bam-7218	1	35	iim	iim	NOUN
bam-7218	1	36	,	,	PUNCT
bam-7218	1	37	the	the	DET
bam-7218	1	38	interuniversity	interuniversity	PROPN
bam-7218	1	39	institute	institute	PROPN
bam-7218	1	40	of	of	ADP
bam-7218	1	41	myology	myology	NOUN
bam-7218	1	42	,	,	PUNCT
bam-7218	1	43	assisi	assisi	PROPN
bam-7218	1	44	(	(	PUNCT
bam-7218	1	45	italy	italy	PROPN
bam-7218	1	46	)	)	PUNCT
bam-7218	1	47	,	,	PUNCT
bam-7218	1	48	october	october	PROPN
bam-7218	1	49	12	12	NUM
bam-7218	1	50	-	-	SYM
bam-7218	1	51	15	15	NUM
bam-7218	1	52	,	,	PUNCT
bam-7218	1	53	2017	2017	NUM
bam-7218	1	54	davide	davide	NOUN
bam-7218	1	55	gabellini	gabellini	NOUN
bam-7218	1	56	(	(	PUNCT
bam-7218	1	57	1	1	NUM
bam-7218	1	58	)	)	PUNCT
bam-7218	1	59	,	,	PUNCT
bam-7218	1	60	antonio	antonio	PROPN
bam-7218	1	61	musarò	musarò	NOUN
bam-7218	1	62	(	(	PUNCT
bam-7218	1	63	2,3	2,3	NUM
bam-7218	1	64	)	)	PUNCT
bam-7218	1	65	(	(	PUNCT
bam-7218	1	66	1	1	X
bam-7218	1	67	)	)	PUNCT
bam-7218	1	68	gene	gene	NOUN
bam-7218	1	69	expression	expression	NOUN
bam-7218	1	70	and	and	CCONJ
bam-7218	1	71	muscular	muscular	ADJ
bam-7218	1	72	dystrophy	dystrophy	NOUN
bam-7218	1	73	unit	unit	NOUN
bam-7218	1	74	,	,	PUNCT
bam-7218	1	75	division	division	NOUN
bam-7218	1	76	of	of	ADP
bam-7218	1	77	genetics	genetic	NOUN
bam-7218	1	78	and	and	CCONJ
bam-7218	1	79	cell	cell	NOUN
bam-7218	1	80	biology	biology	NOUN
bam-7218	1	81	,	,	PUNCT
bam-7218	1	82	irccs	ircc	VERB
bam-7218	1	83	san	san	PROPN
bam-7218	1	84	raffaele	raffaele	PROPN
bam-7218	1	85	scientific	scientific	PROPN
bam-7218	1	86	institute	institute	PROPN
bam-7218	1	87	,	,	PUNCT
bam-7218	1	88	milano	milano	PROPN
bam-7218	1	89	,	,	PUNCT
bam-7218	1	90	italy	italy	PROPN
bam-7218	1	91	;	;	PUNCT
bam-7218	1	92	(	(	PUNCT
bam-7218	1	93	2	2	X
bam-7218	1	94	)	)	PUNCT
bam-7218	1	95	dahfmo	dahfmo	NOUN
bam-7218	1	96	-	-	PUNCT
bam-7218	1	97	unit	unit	NOUN
bam-7218	1	98	of	of	ADP
bam-7218	1	99	histology	histology	NOUN
bam-7218	1	100	and	and	CCONJ
bam-7218	1	101	medical	medical	ADJ
bam-7218	1	102	embryology	embryology	NOUN
bam-7218	1	103	,	,	PUNCT
bam-7218	1	104	laboratory	laboratory	NOUN
bam-7218	1	105	affiliated	affiliate	VERB
bam-7218	1	106	to	to	ADP
bam-7218	1	107	istituto	istituto	PROPN
bam-7218	1	108	pasteur	pasteur	PROPN
bam-7218	1	109	italia	italia	PROPN
bam-7218	1	110	–	–	PUNCT
bam-7218	1	111	fondazione	fondazione	PROPN
bam-7218	1	112	cenci	cenci	PROPN
bam-7218	1	113	bolognetti	bolognetti	PROPN
bam-7218	1	114	,	,	PUNCT
bam-7218	1	115	sapienza	sapienza	PROPN
bam-7218	1	116	university	university	NOUN
bam-7218	1	117	;	;	PUNCT
bam-7218	1	118	(	(	PUNCT
bam-7218	1	119	3	3	X
bam-7218	1	120	)	)	PUNCT
bam-7218	1	121	center	center	NOUN
bam-7218	1	122	for	for	ADP
bam-7218	1	123	life	life	NOUN
bam-7218	1	124	nano	nano	NOUN
bam-7218	1	125	science@sapienza	science@sapienza	PROPN
bam-7218	1	126	,	,	PUNCT
bam-7218	1	127	iit	iit	PROPN
bam-7218	1	128	,	,	PUNCT
bam-7218	1	129	rome	rome	PROPN
bam-7218	1	130	,	,	PUNCT
bam-7218	1	131	italy	italy	PROPN
bam-7218	1	132	.	.	PUNCT
bam-7218	2	1	this	this	DET
bam-7218	2	2	article	article	NOUN
bam-7218	2	3	is	be	AUX
bam-7218	2	4	distributed	distribute	VERB
bam-7218	2	5	under	under	ADP
bam-7218	2	6	the	the	DET
bam-7218	2	7	terms	term	NOUN
bam-7218	2	8	of	of	ADP
bam-7218	2	9	the	the	DET
bam-7218	2	10	creative	creative	ADJ
bam-7218	2	11	commons	common	NOUN
bam-7218	2	12	attribution	attribution	NOUN
bam-7218	2	13	noncommercial	noncommercial	ADJ
bam-7218	2	14	license	license	NOUN
bam-7218	2	15	(	(	PUNCT
bam-7218	2	16	cc	cc	NOUN
bam-7218	2	17	by	by	ADP
bam-7218	2	18	-	-	PUNCT
bam-7218	2	19	nc	nc	PROPN
bam-7218	2	20	4.0	4.0	NUM
bam-7218	2	21	)	)	PUNCT
bam-7218	2	22	which	which	PRON
bam-7218	2	23	permits	permit	VERB
bam-7218	2	24	any	any	DET
bam-7218	2	25	noncommercial	noncommercial	ADJ
bam-7218	2	26	use	use	NOUN
bam-7218	2	27	,	,	PUNCT
bam-7218	2	28	distribution	distribution	NOUN
bam-7218	2	29	,	,	PUNCT
bam-7218	2	30	and	and	CCONJ
bam-7218	2	31	reproduction	reproduction	NOUN
bam-7218	2	32	in	in	ADP
bam-7218	2	33	any	any	DET
bam-7218	2	34	medium	medium	NOUN
bam-7218	2	35	,	,	PUNCT
bam-7218	2	36	provided	provide	VERB
bam-7218	2	37	the	the	DET
bam-7218	2	38	original	original	ADJ
bam-7218	2	39	author(s	author(s	NOUN
bam-7218	2	40	)	)	PUNCT
bam-7218	2	41	and	and	CCONJ
bam-7218	2	42	source	source	NOUN
bam-7218	2	43	are	be	AUX
bam-7218	2	44	credited	credit	VERB
bam-7218	2	45	.	.	PUNCT
bam-7218	3	1	abstract	abstract	ADV
bam-7218	3	2	the	the	DET
bam-7218	3	3	14	14	NUM
bam-7218	3	4	th	th	NOUN
bam-7218	3	5	meeting	meeting	NOUN
bam-7218	3	6	of	of	ADP
bam-7218	3	7	the	the	DET
bam-7218	3	8	interuniversity	interuniversity	PROPN
bam-7218	3	9	institute	institute	PROPN
bam-7218	3	10	of	of	ADP
bam-7218	3	11	myology	myology	NOUN
bam-7218	3	12	(	(	PUNCT
bam-7218	3	13	iim	iim	NOUN
bam-7218	3	14	)	)	PUNCT
bam-7218	3	15	,	,	PUNCT
bam-7218	3	16	october	october	PROPN
bam-7218	3	17	12	12	NUM
bam-7218	3	18	-	-	SYM
bam-7218	3	19	15	15	NUM
bam-7218	3	20	,	,	PUNCT
bam-7218	3	21	2017	2017	NUM
bam-7218	3	22	assisi	assisi	PROPN
bam-7218	3	23	,	,	PUNCT
bam-7218	3	24	italy	italy	PROPN
bam-7218	3	25	gathered	gather	VERB
bam-7218	3	26	together	together	ADV
bam-7218	3	27	researchers	researcher	NOUN
bam-7218	3	28	from	from	ADP
bam-7218	3	29	italy	italy	PROPN
bam-7218	3	30	,	,	PUNCT
bam-7218	3	31	european	european	ADJ
bam-7218	3	32	and	and	CCONJ
bam-7218	3	33	north	north	ADJ
bam-7218	3	34	-	-	PUNCT
bam-7218	3	35	american	american	ADJ
bam-7218	3	36	countries	country	NOUN
bam-7218	3	37	to	to	PART
bam-7218	3	38	discuss	discuss	VERB
bam-7218	3	39	recent	recent	ADJ
bam-7218	3	40	results	result	NOUN
bam-7218	3	41	on	on	ADP
bam-7218	3	42	muscle	muscle	NOUN
bam-7218	3	43	research	research	NOUN
bam-7218	3	44	.	.	PUNCT
bam-7218	4	1	the	the	DET
bam-7218	4	2	program	program	NOUN
bam-7218	4	3	showcased	showcase	VERB
bam-7218	4	4	keynote	keynote	NOUN
bam-7218	4	5	lectures	lecture	NOUN
bam-7218	4	6	from	from	ADP
bam-7218	4	7	world	world	NOUN
bam-7218	4	8	-	-	PUNCT
bam-7218	4	9	renowned	renowne	VERB
bam-7218	4	10	international	international	ADJ
bam-7218	4	11	speakers	speaker	NOUN
bam-7218	4	12	presenting	present	VERB
bam-7218	4	13	advances	advance	NOUN
bam-7218	4	14	in	in	ADP
bam-7218	4	15	muscle	muscle	NOUN
bam-7218	4	16	physiology	physiology	NOUN
bam-7218	4	17	,	,	PUNCT
bam-7218	4	18	bioengineering	bioengineering	NOUN
bam-7218	4	19	,	,	PUNCT
bam-7218	4	20	metabolism	metabolism	NOUN
bam-7218	4	21	and	and	CCONJ
bam-7218	4	22	therapeutics	therapeutic	NOUN
bam-7218	4	23	.	.	PUNCT
bam-7218	5	1	based	base	VERB
bam-7218	5	2	on	on	ADP
bam-7218	5	3	selection	selection	NOUN
bam-7218	5	4	from	from	ADP
bam-7218	5	5	submitted	submit	VERB
bam-7218	5	6	abstracts	abstract	NOUN
bam-7218	5	7	,	,	PUNCT
bam-7218	5	8	participants	participant	NOUN
bam-7218	5	9	presented	present	VERB
bam-7218	5	10	their	their	PRON
bam-7218	5	11	novel	novel	NOUN
bam-7218	5	12	,	,	PUNCT
bam-7218	5	13	unpublished	unpublished	ADJ
bam-7218	5	14	results	result	NOUN
bam-7218	5	15	in	in	ADP
bam-7218	5	16	seven	seven	NUM
bam-7218	5	17	oral	oral	ADJ
bam-7218	5	18	communication	communication	NOUN
bam-7218	5	19	and	and	CCONJ
bam-7218	5	20	two	two	NUM
bam-7218	5	21	poster	poster	NOUN
bam-7218	5	22	sessions	session	NOUN
bam-7218	5	23	.	.	PUNCT
bam-7218	6	1	particular	particular	ADJ
bam-7218	6	2	emphasis	emphasis	NOUN
bam-7218	6	3	was	be	AUX
bam-7218	6	4	devoted	devote	VERB
bam-7218	6	5	to	to	ADP
bam-7218	6	6	young	young	ADJ
bam-7218	6	7	trainees	trainee	NOUN
bam-7218	6	8	.	.	PUNCT
bam-7218	7	1	for	for	ADP
bam-7218	7	2	example	example	NOUN
bam-7218	7	3	,	,	PUNCT
bam-7218	7	4	trainees	trainee	NOUN
bam-7218	7	5	where	where	SCONJ
bam-7218	7	6	directly	directly	ADV
bam-7218	7	7	involved	involve	VERB
bam-7218	7	8	in	in	ADP
bam-7218	7	9	organizing	organize	VERB
bam-7218	7	10	a	a	DET
bam-7218	7	11	scientific	scientific	ADJ
bam-7218	7	12	session	session	NOUN
bam-7218	7	13	and	and	CCONJ
bam-7218	7	14	three	three	NUM
bam-7218	7	15	round	round	ADJ
bam-7218	7	16	tables	table	NOUN
bam-7218	7	17	tailored	tailor	VERB
bam-7218	7	18	to	to	ADP
bam-7218	7	19	the	the	DET
bam-7218	7	20	interests	interest	NOUN
bam-7218	7	21	of	of	ADP
bam-7218	7	22	their	their	PRON
bam-7218	7	23	peers	peer	NOUN
bam-7218	7	24	.	.	PUNCT
bam-7218	8	1	the	the	DET
bam-7218	8	2	meeting	meeting	NOUN
bam-7218	8	3	attracted	attract	VERB
bam-7218	8	4	a	a	DET
bam-7218	8	5	broad	broad	ADJ
bam-7218	8	6	audience	audience	NOUN
bam-7218	8	7	from	from	ADP
bam-7218	8	8	italy	italy	PROPN
bam-7218	8	9	,	,	PUNCT
bam-7218	8	10	various	various	ADJ
bam-7218	8	11	european	european	ADJ
bam-7218	8	12	countries	country	NOUN
bam-7218	8	13	and	and	CCONJ
bam-7218	8	14	from	from	ADP
bam-7218	8	15	north	north	PROPN
bam-7218	8	16	america	america	PROPN
bam-7218	8	17	.	.	PUNCT
bam-7218	9	1	it	it	PRON
bam-7218	9	2	offered	offer	VERB
bam-7218	9	3	a	a	DET
bam-7218	9	4	unique	unique	ADJ
bam-7218	9	5	opportunity	opportunity	NOUN
bam-7218	9	6	to	to	ADP
bam-7218	9	7	all	all	DET
bam-7218	9	8	researchers	researcher	NOUN
bam-7218	9	9	involved	involve	VERB
bam-7218	9	10	in	in	ADP
bam-7218	9	11	the	the	DET
bam-7218	9	12	field	field	NOUN
bam-7218	9	13	of	of	ADP
bam-7218	9	14	muscle	muscle	NOUN
bam-7218	9	15	biology	biology	NOUN
bam-7218	9	16	to	to	PART
bam-7218	9	17	exchange	exchange	VERB
bam-7218	9	18	ideas	idea	NOUN
bam-7218	9	19	and	and	CCONJ
bam-7218	9	20	foster	foster	ADJ
bam-7218	9	21	scientific	scientific	ADJ
bam-7218	9	22	collaborations	collaboration	NOUN
bam-7218	9	23	to	to	PART
bam-7218	9	24	better	well	ADV
bam-7218	9	25	understand	understand	VERB
bam-7218	9	26	the	the	DET
bam-7218	9	27	causative	causative	ADJ
bam-7218	9	28	mechanisms	mechanism	NOUN
bam-7218	9	29	of	of	ADP
bam-7218	9	30	muscular	muscular	ADJ
bam-7218	9	31	diseases	disease	NOUN
bam-7218	9	32	and	and	CCONJ
bam-7218	9	33	to	to	PART
bam-7218	9	34	improve	improve	VERB
bam-7218	9	35	the	the	DET
bam-7218	9	36	design	design	NOUN
bam-7218	9	37	of	of	ADP
bam-7218	9	38	more	more	ADV
bam-7218	9	39	efficient	efficient	ADJ
bam-7218	9	40	therapeutic	therapeutic	ADJ
bam-7218	9	41	strategies	strategy	NOUN
bam-7218	9	42	.	.	PUNCT
bam-7218	10	1	the	the	DET
bam-7218	10	2	friendly	friendly	ADJ
bam-7218	10	3	and	and	CCONJ
bam-7218	10	4	inclusive	inclusive	ADJ
bam-7218	10	5	atmosphere	atmosphere	NOUN
bam-7218	10	6	promoted	promote	VERB
bam-7218	10	7	the	the	DET
bam-7218	10	8	active	active	ADJ
bam-7218	10	9	participation	participation	NOUN
bam-7218	10	10	of	of	ADP
bam-7218	10	11	junior	junior	ADJ
bam-7218	10	12	scientists	scientist	NOUN
bam-7218	10	13	to	to	ADP
bam-7218	10	14	exciting	exciting	ADJ
bam-7218	10	15	discussions	discussion	NOUN
bam-7218	10	16	,	,	PUNCT
bam-7218	10	17	which	which	PRON
bam-7218	10	18	allowed	allow	VERB
bam-7218	10	19	to	to	PART
bam-7218	10	20	identify	identify	VERB
bam-7218	10	21	emerging	emerge	VERB
bam-7218	10	22	areas	area	NOUN
bam-7218	10	23	of	of	ADP
bam-7218	10	24	myology	myology	NOUN
bam-7218	10	25	research	research	NOUN
bam-7218	10	26	and	and	CCONJ
bam-7218	10	27	encouraged	encourage	VERB
bam-7218	10	28	scientific	scientific	ADJ
bam-7218	10	29	cross	cross	NOUN
bam-7218	10	30	-	-	NOUN
bam-7218	10	31	fertilization	fertilization	NOUN
bam-7218	10	32	to	to	PART
bam-7218	10	33	facilitate	facilitate	VERB
bam-7218	10	34	exchanges	exchange	NOUN
bam-7218	10	35	between	between	ADP
bam-7218	10	36	different	different	ADJ
bam-7218	10	37	laboratories	laboratory	NOUN
bam-7218	10	38	in	in	ADP
bam-7218	10	39	different	different	ADJ
bam-7218	10	40	countries	country	NOUN
bam-7218	10	41	.	.	PUNCT
bam-7218	11	1	the	the	DET
bam-7218	11	2	meeting	meeting	NOUN
bam-7218	11	3	was	be	AUX
bam-7218	11	4	a	a	DET
bam-7218	11	5	success	success	NOUN
bam-7218	11	6	and	and	CCONJ
bam-7218	11	7	this	this	DET
bam-7218	11	8	community	community	NOUN
bam-7218	11	9	will	will	AUX
bam-7218	11	10	continue	continue	VERB
bam-7218	11	11	to	to	PART
bam-7218	11	12	deliver	deliver	VERB
bam-7218	11	13	major	major	ADJ
bam-7218	11	14	contributions	contribution	NOUN
bam-7218	11	15	to	to	ADP
bam-7218	11	16	our	our	PRON
bam-7218	11	17	understanding	understanding	NOUN
bam-7218	11	18	of	of	ADP
bam-7218	11	19	muscle	muscle	NOUN
bam-7218	11	20	development	development	NOUN
bam-7218	11	21	and	and	CCONJ
bam-7218	11	22	function	function	NOUN
bam-7218	11	23	,	,	PUNCT
bam-7218	11	24	the	the	DET
bam-7218	11	25	pathogenesis	pathogenesis	NOUN
bam-7218	11	26	of	of	ADP
bam-7218	11	27	muscle	muscle	NOUN
bam-7218	11	28	diseases	disease	NOUN
bam-7218	11	29	and	and	CCONJ
bam-7218	11	30	the	the	DET
bam-7218	11	31	development	development	NOUN
bam-7218	11	32	of	of	ADP
bam-7218	11	33	novel	novel	ADJ
bam-7218	11	34	therapeutic	therapeutic	ADJ
bam-7218	11	35	approaches	approach	NOUN
bam-7218	11	36	.	.	PUNCT
bam-7218	12	1	here	here	ADV
bam-7218	12	2	,	,	PUNCT
bam-7218	12	3	we	we	PRON
bam-7218	12	4	report	report	VERB
bam-7218	12	5	abstracts	abstract	NOUN
bam-7218	12	6	of	of	ADP
bam-7218	12	7	the	the	DET
bam-7218	12	8	meeting	meeting	NOUN
bam-7218	12	9	discussing	discuss	VERB
bam-7218	12	10	recent	recent	ADJ
bam-7218	12	11	results	result	NOUN
bam-7218	12	12	of	of	ADP
bam-7218	12	13	basic	basic	ADJ
bam-7218	12	14	,	,	PUNCT
bam-7218	12	15	translational	translational	ADJ
bam-7218	12	16	and	and	CCONJ
bam-7218	12	17	early	early	ADJ
bam-7218	12	18	clinical	clinical	ADJ
bam-7218	12	19	studies	study	NOUN
bam-7218	12	20	confirming	confirm	VERB
bam-7218	12	21	that	that	SCONJ
bam-7218	12	22	the	the	DET
bam-7218	12	23	field	field	NOUN
bam-7218	12	24	of	of	ADP
bam-7218	12	25	myology	myology	NOUN
bam-7218	12	26	is	be	AUX
bam-7218	12	27	strong	strong	ADJ
bam-7218	12	28	and	and	CCONJ
bam-7218	12	29	articulated	articulated	ADJ
bam-7218	12	30	,	,	PUNCT
bam-7218	12	31	maturing	mature	VERB
bam-7218	12	32	toward	toward	ADP
bam-7218	12	33	clinical	clinical	ADJ
bam-7218	12	34	development	development	NOUN
bam-7218	12	35	for	for	ADP
bam-7218	12	36	the	the	DET
bam-7218	12	37	treatment	treatment	NOUN
bam-7218	12	38	of	of	ADP
bam-7218	12	39	muscle	muscle	NOUN
bam-7218	12	40	diseases	disease	NOUN
bam-7218	12	41	.	.	PUNCT
bam-7218	13	1	key	key	ADJ
bam-7218	13	2	words	word	NOUN
bam-7218	13	3	:	:	PUNCT
bam-7218	13	4	muscle	muscle	NOUN
bam-7218	13	5	development	development	NOUN
bam-7218	13	6	,	,	PUNCT
bam-7218	13	7	stem	stem	NOUN
bam-7218	13	8	cells	cell	NOUN
bam-7218	13	9	,	,	PUNCT
bam-7218	13	10	regeneration	regeneration	NOUN
bam-7218	13	11	,	,	PUNCT
bam-7218	13	12	epigenetics	epigenetic	NOUN
bam-7218	13	13	,	,	PUNCT
bam-7218	13	14	muscle	muscle	NOUN
bam-7218	13	15	wasting	wasting	NOUN
bam-7218	13	16	,	,	PUNCT
bam-7218	13	17	proof	proof	NOUN
bam-7218	13	18	of	of	ADP
bam-7218	13	19	concept	concept	NOUN
bam-7218	13	20	,	,	PUNCT
bam-7218	13	21	translational	translational	ADJ
bam-7218	13	22	myology	myology	NOUN
bam-7218	13	23	,	,	PUNCT
bam-7218	13	24	ex	ex	NOUN
bam-7218	13	25	-	-	NOUN
bam-7218	13	26	vivo	vivo	ADJ
bam-7218	13	27	and	and	CCONJ
bam-7218	13	28	in	in	ADP
bam-7218	13	29	-	-	PUNCT
bam-7218	13	30	vivo	vivo	NOUN
bam-7218	13	31	studies	study	NOUN
bam-7218	13	32	,	,	PUNCT
bam-7218	13	33	clinical	clinical	ADJ
bam-7218	13	34	trials	trial	NOUN
bam-7218	13	35	eur	eur	PROPN
bam-7218	13	36	j	j	PROPN
bam-7218	13	37	transl	transl	PROPN
bam-7218	13	38	myol	myol	ADV
bam-7218	13	39	27	27	NUM
bam-7218	13	40	(	(	PUNCT
bam-7218	13	41	4	4	NUM
bam-7218	13	42	):	):	SYM
bam-7218	13	43	185	185	NUM
bam-7218	13	44	-	-	SYM
bam-7218	13	45	22	22	NUM
bam-7218	13	46	founded	found	VERB
bam-7218	13	47	in	in	ADP
bam-7218	13	48	2003	2003	NUM
bam-7218	13	49	,	,	PUNCT
bam-7218	13	50	the	the	DET
bam-7218	13	51	interuniversity	interuniversity	PROPN
bam-7218	13	52	institute	institute	PROPN
bam-7218	13	53	of	of	ADP
bam-7218	13	54	myology	myology	NOUN
bam-7218	13	55	(	(	PUNCT
bam-7218	13	56	imm	imm	NOUN
bam-7218	13	57	)	)	PUNCT
bam-7218	13	58	brings	bring	VERB
bam-7218	13	59	together	together	ADP
bam-7218	13	60	investigators	investigator	NOUN
bam-7218	13	61	performing	perform	VERB
bam-7218	13	62	muscle	muscle	NOUN
bam-7218	13	63	research	research	NOUN
bam-7218	13	64	in	in	ADP
bam-7218	13	65	universities	university	NOUN
bam-7218	13	66	and	and	CCONJ
bam-7218	13	67	research	research	NOUN
bam-7218	13	68	centers	center	NOUN
bam-7218	13	69	in	in	ADP
bam-7218	13	70	italy	italy	PROPN
bam-7218	13	71	and	and	CCONJ
bam-7218	13	72	abroad	abroad	ADV
bam-7218	13	73	.	.	PUNCT
bam-7218	14	1	iim	iim	NOUN
bam-7218	14	2	mission	mission	NOUN
bam-7218	14	3	is	be	AUX
bam-7218	14	4	to	to	PART
bam-7218	14	5	promote	promote	VERB
bam-7218	14	6	interdisciplinary	interdisciplinary	ADJ
bam-7218	14	7	collaborative	collaborative	ADJ
bam-7218	14	8	efforts	effort	NOUN
bam-7218	14	9	to	to	PART
bam-7218	14	10	further	further	VERB
bam-7218	14	11	the	the	DET
bam-7218	14	12	understanding	understanding	NOUN
bam-7218	14	13	of	of	ADP
bam-7218	14	14	normal	normal	ADJ
bam-7218	14	15	and	and	CCONJ
bam-7218	14	16	pathological	pathological	ADJ
bam-7218	14	17	aspects	aspect	NOUN
bam-7218	14	18	of	of	ADP
bam-7218	14	19	muscle	muscle	NOUN
bam-7218	14	20	formation	formation	NOUN
bam-7218	14	21	,	,	PUNCT
bam-7218	14	22	activity	activity	NOUN
bam-7218	14	23	and	and	CCONJ
bam-7218	14	24	repair	repair	NOUN
bam-7218	14	25	,	,	PUNCT
bam-7218	14	26	as	as	ADV
bam-7218	14	27	well	well	ADV
bam-7218	14	28	as	as	ADP
bam-7218	14	29	to	to	PART
bam-7218	14	30	foster	foster	VERB
bam-7218	14	31	collaborations	collaboration	NOUN
bam-7218	14	32	between	between	ADP
bam-7218	14	33	researchers	researcher	NOUN
bam-7218	14	34	,	,	PUNCT
bam-7218	14	35	clinicians	clinician	NOUN
bam-7218	14	36	and	and	CCONJ
bam-7218	14	37	patient	patient	ADJ
bam-7218	14	38	associations	association	NOUN
bam-7218	14	39	for	for	ADP
bam-7218	14	40	the	the	DET
bam-7218	14	41	development	development	NOUN
bam-7218	14	42	of	of	ADP
bam-7218	14	43	therapeutic	therapeutic	ADJ
bam-7218	14	44	treatments	treatment	NOUN
bam-7218	14	45	for	for	ADP
bam-7218	14	46	neuromuscular	neuromuscular	ADJ
bam-7218	14	47	diseases	disease	NOUN
bam-7218	14	48	.	.	PUNCT
bam-7218	15	1	special	special	ADJ
bam-7218	15	2	emphasis	emphasis	NOUN
bam-7218	15	3	is	be	AUX
bam-7218	15	4	devoted	devote	VERB
bam-7218	15	5	to	to	ADP
bam-7218	15	6	the	the	DET
bam-7218	15	7	training	training	NOUN
bam-7218	15	8	of	of	ADP
bam-7218	15	9	young	young	ADJ
bam-7218	15	10	fellows	fellow	NOUN
bam-7218	15	11	,	,	PUNCT
bam-7218	15	12	and	and	CCONJ
bam-7218	15	13	to	to	PART
bam-7218	15	14	promote	promote	VERB
bam-7218	15	15	international	international	ADJ
bam-7218	15	16	collaborations	collaboration	NOUN
bam-7218	15	17	and	and	CCONJ
bam-7218	15	18	exchanges	exchange	NOUN
bam-7218	15	19	.	.	PUNCT
bam-7218	16	1	at	at	ADP
bam-7218	16	2	the	the	DET
bam-7218	16	3	recent	recent	ADJ
bam-7218	16	4	14	14	NUM
bam-7218	16	5	th	th	NUM
bam-7218	16	6	iim	iim	PROPN
bam-7218	16	7	meeting	meeting	NOUN
bam-7218	16	8	,	,	PUNCT
bam-7218	16	9	held	hold	VERB
bam-7218	16	10	in	in	ADP
bam-7218	16	11	assisi	assisi	PROPN
bam-7218	16	12	,	,	PUNCT
bam-7218	16	13	italy	italy	PROPN
bam-7218	16	14	october	october	PROPN
bam-7218	16	15	12	12	NUM
bam-7218	16	16	-	-	SYM
bam-7218	16	17	15	15	NUM
bam-7218	16	18	,	,	PUNCT
bam-7218	16	19	2017	2017	NUM
bam-7218	16	20	,	,	PUNCT
bam-7218	16	21	junior	junior	ADJ
bam-7218	16	22	and	and	CCONJ
bam-7218	16	23	senior	senior	ADJ
bam-7218	16	24	myologists	myologist	NOUN
bam-7218	16	25	from	from	ADP
bam-7218	16	26	italian	italian	ADJ
bam-7218	16	27	universities	university	NOUN
bam-7218	16	28	and	and	CCONJ
bam-7218	16	29	research	research	NOUN
bam-7218	16	30	centers	center	NOUN
bam-7218	16	31	gathered	gather	VERB
bam-7218	16	32	with	with	ADP
bam-7218	16	33	international	international	ADJ
bam-7218	16	34	colleagues	colleague	NOUN
bam-7218	16	35	to	to	PART
bam-7218	16	36	present	present	VERB
bam-7218	16	37	recent	recent	ADJ
bam-7218	16	38	biomedical	biomedical	ADJ
bam-7218	16	39	and	and	CCONJ
bam-7218	16	40	clinical	clinical	ADJ
bam-7218	16	41	results	result	NOUN
bam-7218	16	42	.	.	PUNCT
bam-7218	17	1	forty	forty	NUM
bam-7218	17	2	four	four	NUM
bam-7218	17	3	oral	oral	ADJ
bam-7218	17	4	communications	communication	NOUN
bam-7218	17	5	were	be	AUX
bam-7218	17	6	grouped	group	VERB
bam-7218	17	7	in	in	ADP
bam-7218	17	8	seven	seven	NUM
bam-7218	17	9	sessions	session	NOUN
bam-7218	17	10	:	:	PUNCT
bam-7218	18	1	1	1	X
bam-7218	18	2	.	.	X
bam-7218	18	3	signaling	signal	VERB
bam-7218	18	4	in	in	ADP
bam-7218	18	5	muscle	muscle	NOUN
bam-7218	18	6	growth	growth	NOUN
bam-7218	18	7	,	,	PUNCT
bam-7218	18	8	homeostasis	homeostasis	NOUN
bam-7218	18	9	and	and	CCONJ
bam-7218	18	10	disease	disease	NOUN
bam-7218	18	11	;	;	PUNCT
bam-7218	18	12	2	2	X
bam-7218	18	13	.	.	X
bam-7218	18	14	biophysics	biophysic	NOUN
bam-7218	18	15	and	and	CCONJ
bam-7218	18	16	e	e	NOUN
bam-7218	18	17	-	-	PROPN
bam-7218	18	18	c	c	ADJ
bam-7218	18	19	coupling	coupling	NOUN
bam-7218	18	20	in	in	ADP
bam-7218	18	21	the	the	DET
bam-7218	18	22	pathophysiology	pathophysiology	NOUN
bam-7218	18	23	of	of	ADP
bam-7218	18	24	neuromuscular	neuromuscular	ADJ
bam-7218	18	25	diseases	disease	NOUN
bam-7218	18	26	;	;	PUNCT
bam-7218	18	27	3	3	X
bam-7218	18	28	.	.	X
bam-7218	18	29	satellite	satellite	NOUN
bam-7218	18	30	cells	cell	NOUN
bam-7218	18	31	and	and	CCONJ
bam-7218	18	32	muscle	muscle	NOUN
bam-7218	18	33	regeneration	regeneration	NOUN
bam-7218	18	34	in	in	ADP
bam-7218	18	35	healthy	healthy	ADJ
bam-7218	18	36	muscle	muscle	NOUN
bam-7218	18	37	and	and	CCONJ
bam-7218	18	38	in	in	ADP
bam-7218	18	39	diseases	disease	NOUN
bam-7218	18	40	;	;	PUNCT
bam-7218	18	41	4	4	X
bam-7218	18	42	.	.	X
bam-7218	18	43	genetic	genetic	ADJ
bam-7218	18	44	and	and	CCONJ
bam-7218	18	45	epigenetic	epigenetic	ADJ
bam-7218	18	46	alterations	alteration	NOUN
bam-7218	18	47	in	in	ADP
bam-7218	18	48	muscle	muscle	NOUN
bam-7218	18	49	dystrophies	dystrophy	NOUN
bam-7218	18	50	and	and	CCONJ
bam-7218	18	51	myopathies	myopathy	NOUN
bam-7218	18	52	;	;	PUNCT
bam-7218	18	53	5	5	X
bam-7218	18	54	.	.	X
bam-7218	18	55	metabolic	metabolic	NOUN
bam-7218	18	56	alterations	alteration	NOUN
bam-7218	18	57	and	and	CCONJ
bam-7218	18	58	muscle	muscle	NOUN
bam-7218	18	59	diseases	disease	NOUN
bam-7218	18	60	;	;	PUNCT
bam-7218	18	61	6	6	X
bam-7218	18	62	.	.	X
bam-7218	18	63	therapeutic	therapeutic	ADJ
bam-7218	18	64	approaches	approach	NOUN
bam-7218	18	65	for	for	ADP
bam-7218	18	66	muscle	muscle	NOUN
bam-7218	18	67	diseases	disease	NOUN
bam-7218	18	68	;	;	PUNCT
bam-7218	18	69	14	14	NUM
bam-7218	18	70	th	th	NUM
bam-7218	18	71	iiim	iiim	NOUN
bam-7218	18	72	meeting	meeting	NOUN
bam-7218	18	73	,	,	PUNCT
bam-7218	18	74	assisi	assisi	PROPN
bam-7218	18	75	,	,	PUNCT
bam-7218	18	76	italy	italy	PROPN
bam-7218	18	77	october	october	PROPN
bam-7218	18	78	12	12	NUM
bam-7218	18	79	-	-	SYM
bam-7218	18	80	15	15	NUM
bam-7218	18	81	2017	2017	NUM
bam-7218	18	82	eur	eur	PROPN
bam-7218	18	83	j	j	PROPN
bam-7218	18	84	transl	transl	PROPN
bam-7218	18	85	myol	myol	ADV
bam-7218	18	86	27	27	NUM
bam-7218	18	87	(	(	PUNCT
bam-7218	18	88	4	4	NUM
bam-7218	18	89	):	):	SYM
bam-7218	18	90	185	185	NUM
bam-7218	18	91	-	-	SYM
bam-7218	18	92	224	224	NUM
bam-7218	18	93	186	186	NUM
bam-7218	18	94	7	7	NUM
bam-7218	18	95	.	.	PUNCT
bam-7218	18	96	muscle	muscle	NOUN
bam-7218	18	97	wasting	wasting	NOUN
bam-7218	18	98	,	,	PUNCT
bam-7218	18	99	sarcopenia	sarcopenia	NOUN
bam-7218	18	100	and	and	CCONJ
bam-7218	18	101	cachexia	cachexia	NOUN
bam-7218	18	102	.	.	PUNCT
bam-7218	19	1	thirty	thirty	NUM
bam-7218	19	2	five	five	NUM
bam-7218	19	3	poster	poster	NOUN
bam-7218	19	4	presentations	presentation	NOUN
bam-7218	19	5	where	where	SCONJ
bam-7218	19	6	always	always	ADV
bam-7218	19	7	on	on	ADP
bam-7218	19	8	display	display	NOUN
bam-7218	19	9	during	during	ADP
bam-7218	19	10	the	the	DET
bam-7218	19	11	entire	entire	ADJ
bam-7218	19	12	meeting	meeting	NOUN
bam-7218	19	13	.	.	PUNCT
bam-7218	20	1	four	four	NUM
bam-7218	20	2	keynote	keynote	ADJ
bam-7218	20	3	lectures	lecture	NOUN
bam-7218	20	4	of	of	ADP
bam-7218	20	5	marco	marco	PROPN
bam-7218	20	6	linari	linari	PROPN
bam-7218	20	7	(	(	PUNCT
bam-7218	20	8	physiolab	physiolab	PROPN
bam-7218	20	9	,	,	PUNCT
bam-7218	20	10	university	university	NOUN
bam-7218	20	11	of	of	ADP
bam-7218	20	12	florence	florence	NOUN
bam-7218	20	13	,	,	PUNCT
bam-7218	20	14	italy	italy	PROPN
bam-7218	20	15	)	)	PUNCT
bam-7218	20	16	,	,	PUNCT
bam-7218	20	17	nicola	nicola	PROPN
bam-7218	20	18	elvassore	elvassore	PROPN
bam-7218	20	19	(	(	PUNCT
bam-7218	20	20	venetian	venetian	PROPN
bam-7218	20	21	institute	institute	NOUN
bam-7218	20	22	of	of	ADP
bam-7218	20	23	molecular	molecular	ADJ
bam-7218	20	24	medicine	medicine	NOUN
bam-7218	20	25	,	,	PUNCT
bam-7218	20	26	padova	padova	PROPN
bam-7218	20	27	,	,	PUNCT
bam-7218	20	28	italy	italy	PROPN
bam-7218	20	29	)	)	PUNCT
bam-7218	20	30	,	,	PUNCT
bam-7218	20	31	jorge	jorge	PROPN
bam-7218	20	32	ruas	ruas	PROPN
bam-7218	20	33	(	(	PUNCT
bam-7218	20	34	department	department	NOUN
bam-7218	20	35	of	of	ADP
bam-7218	20	36	physiology	physiology	NOUN
bam-7218	20	37	and	and	CCONJ
bam-7218	20	38	pharmacology	pharmacology	NOUN
bam-7218	20	39	,	,	PUNCT
bam-7218	20	40	karolinska	karolinska	PROPN
bam-7218	20	41	institute	institute	PROPN
bam-7218	20	42	,	,	PUNCT
bam-7218	20	43	stockholm	stockholm	PROPN
bam-7218	20	44	,	,	PUNCT
bam-7218	20	45	sweden	sweden	PROPN
bam-7218	20	46	)	)	PUNCT
bam-7218	20	47	,	,	PUNCT
bam-7218	20	48	and	and	CCONJ
bam-7218	20	49	mark	mark	PROPN
bam-7218	20	50	tarnopolsky	tarnopolsky	PROPN
bam-7218	20	51	(	(	PUNCT
bam-7218	20	52	mcmaster	mcmaster	PROPN
bam-7218	20	53	university	university	PROPN
bam-7218	20	54	medical	medical	ADJ
bam-7218	20	55	center	center	PROPN
bam-7218	20	56	,	,	PUNCT
bam-7218	20	57	hamilton	hamilton	PROPN
bam-7218	20	58	,	,	PUNCT
bam-7218	20	59	on	on	ADP
bam-7218	20	60	,	,	PUNCT
bam-7218	20	61	canada	canada	PROPN
bam-7218	20	62	)	)	PUNCT
bam-7218	20	63	completed	complete	VERB
bam-7218	20	64	the	the	DET
bam-7218	20	65	program	program	NOUN
bam-7218	20	66	of	of	ADP
bam-7218	20	67	the	the	DET
bam-7218	20	68	three	three	NUM
bam-7218	20	69	days	day	NOUN
bam-7218	20	70	of	of	ADP
bam-7218	20	71	the	the	DET
bam-7218	20	72	meeting	meeting	NOUN
bam-7218	20	73	.	.	PUNCT
bam-7218	21	1	scientific	scientific	ADJ
bam-7218	21	2	discussions	discussion	NOUN
bam-7218	21	3	were	be	AUX
bam-7218	21	4	very	very	ADV
bam-7218	21	5	interesting	interesting	ADJ
bam-7218	21	6	and	and	CCONJ
bam-7218	21	7	new	new	ADJ
bam-7218	21	8	collaborations	collaboration	NOUN
bam-7218	21	9	were	be	AUX
bam-7218	21	10	developed	develop	VERB
bam-7218	21	11	during	during	ADP
bam-7218	21	12	the	the	DET
bam-7218	21	13	scientific	scientific	ADJ
bam-7218	21	14	sessions	session	NOUN
bam-7218	21	15	and	and	CCONJ
bam-7218	21	16	through	through	ADP
bam-7218	21	17	spontaneous	spontaneous	ADJ
bam-7218	21	18	gatherings	gathering	NOUN
bam-7218	21	19	of	of	ADP
bam-7218	21	20	several	several	ADJ
bam-7218	21	21	after	after	ADP
bam-7218	21	22	lunch	lunch	NOUN
bam-7218	21	23	and	and	CCONJ
bam-7218	21	24	dinner	dinner	NOUN
bam-7218	21	25	.	.	PUNCT
bam-7218	22	1	the	the	DET
bam-7218	22	2	international	international	ADJ
bam-7218	22	3	participation	participation	NOUN
bam-7218	22	4	is	be	AUX
bam-7218	22	5	increasing	increase	VERB
bam-7218	22	6	every	every	DET
bam-7218	22	7	year	year	NOUN
bam-7218	22	8	,	,	PUNCT
bam-7218	22	9	a	a	DET
bam-7218	22	10	strong	strong	ADJ
bam-7218	22	11	evidence	evidence	NOUN
bam-7218	22	12	that	that	SCONJ
bam-7218	22	13	the	the	DET
bam-7218	22	14	italian	italian	ADJ
bam-7218	22	15	community	community	NOUN
bam-7218	22	16	of	of	ADP
bam-7218	22	17	myologists	myologist	NOUN
bam-7218	22	18	has	have	AUX
bam-7218	22	19	high	high	ADJ
bam-7218	22	20	standards	standard	NOUN
bam-7218	22	21	and	and	CCONJ
bam-7218	22	22	is	be	AUX
bam-7218	22	23	able	able	ADJ
bam-7218	22	24	to	to	PART
bam-7218	22	25	attract	attract	VERB
bam-7218	22	26	young	young	ADJ
bam-7218	22	27	and	and	CCONJ
bam-7218	22	28	senior	senior	ADJ
bam-7218	22	29	scientists	scientist	NOUN
bam-7218	22	30	.	.	PUNCT
bam-7218	23	1	the	the	DET
bam-7218	23	2	meeting	meeting	NOUN
bam-7218	23	3	has	have	AUX
bam-7218	23	4	been	be	AUX
bam-7218	23	5	highly	highly	ADV
bam-7218	23	6	successful	successful	ADJ
bam-7218	23	7	and	and	CCONJ
bam-7218	23	8	instrumental	instrumental	ADJ
bam-7218	23	9	to	to	PART
bam-7218	23	10	facilitate	facilitate	VERB
bam-7218	23	11	exchanges	exchange	NOUN
bam-7218	23	12	between	between	ADP
bam-7218	23	13	different	different	ADJ
bam-7218	23	14	laboratories	laboratory	NOUN
bam-7218	23	15	of	of	ADP
bam-7218	23	16	different	different	ADJ
bam-7218	23	17	countries	country	NOUN
bam-7218	23	18	.	.	PUNCT
bam-7218	24	1	it	it	PRON
bam-7218	24	2	was	be	AUX
bam-7218	24	3	also	also	ADV
bam-7218	24	4	very	very	ADV
bam-7218	24	5	valuable	valuable	ADJ
bam-7218	24	6	for	for	ADP
bam-7218	24	7	identifying	identify	VERB
bam-7218	24	8	emerging	emerge	VERB
bam-7218	24	9	areas	area	NOUN
bam-7218	24	10	of	of	ADP
bam-7218	24	11	research	research	NOUN
bam-7218	24	12	and	and	CCONJ
bam-7218	24	13	to	to	PART
bam-7218	24	14	encourage	encourage	VERB
bam-7218	24	15	the	the	DET
bam-7218	24	16	active	active	ADJ
bam-7218	24	17	participation	participation	NOUN
bam-7218	24	18	of	of	ADP
bam-7218	24	19	qualified	qualified	ADJ
bam-7218	24	20	researchers	researcher	NOUN
bam-7218	24	21	and	and	CCONJ
bam-7218	24	22	junior	junior	ADJ
bam-7218	24	23	scientists	scientist	NOUN
bam-7218	24	24	in	in	ADP
bam-7218	24	25	the	the	DET
bam-7218	24	26	field	field	NOUN
bam-7218	24	27	.	.	PUNCT
bam-7218	25	1	in	in	ADP
bam-7218	25	2	particular	particular	ADJ
bam-7218	25	3	,	,	PUNCT
bam-7218	25	4	the	the	DET
bam-7218	25	5	iim	iim	NOUN
bam-7218	25	6	-	-	PUNCT
bam-7218	25	7	myology	myology	NOUN
bam-7218	25	8	meeting	meeting	NOUN
bam-7218	25	9	offered	offer	VERB
bam-7218	25	10	an	an	DET
bam-7218	25	11	unique	unique	ADJ
bam-7218	25	12	opportunity	opportunity	NOUN
bam-7218	25	13	to	to	ADP
bam-7218	25	14	all	all	DET
bam-7218	25	15	researchers	researcher	NOUN
bam-7218	25	16	involved	involve	VERB
bam-7218	25	17	in	in	ADP
bam-7218	25	18	the	the	DET
bam-7218	25	19	field	field	NOUN
bam-7218	25	20	of	of	ADP
bam-7218	25	21	myology	myology	NOUN
bam-7218	25	22	to	to	PART
bam-7218	25	23	exchange	exchange	VERB
bam-7218	25	24	ideas	idea	NOUN
bam-7218	25	25	and	and	CCONJ
bam-7218	25	26	stimulate	stimulate	VERB
bam-7218	25	27	scientific	scientific	ADJ
bam-7218	25	28	collaborations	collaboration	NOUN
bam-7218	25	29	in	in	ADP
bam-7218	25	30	order	order	NOUN
bam-7218	25	31	to	to	PART
bam-7218	25	32	better	well	ADV
bam-7218	25	33	understand	understand	VERB
bam-7218	25	34	the	the	DET
bam-7218	25	35	causative	causative	ADJ
bam-7218	25	36	mechanisms	mechanism	NOUN
bam-7218	25	37	of	of	ADP
bam-7218	25	38	muscular	muscular	ADJ
bam-7218	25	39	diseases	disease	NOUN
bam-7218	25	40	and	and	CCONJ
bam-7218	25	41	to	to	PART
bam-7218	25	42	improve	improve	VERB
bam-7218	25	43	the	the	DET
bam-7218	25	44	design	design	NOUN
bam-7218	25	45	of	of	ADP
bam-7218	25	46	more	more	ADV
bam-7218	25	47	efficient	efficient	ADJ
bam-7218	25	48	therapeutic	therapeutic	ADJ
bam-7218	25	49	strategies	strategy	NOUN
bam-7218	25	50	.	.	PUNCT
bam-7218	26	1	it	it	PRON
bam-7218	26	2	is	be	AUX
bam-7218	26	3	very	very	ADV
bam-7218	26	4	likely	likely	ADJ
bam-7218	26	5	that	that	SCONJ
bam-7218	26	6	this	this	DET
bam-7218	26	7	community	community	NOUN
bam-7218	26	8	will	will	AUX
bam-7218	26	9	continue	continue	VERB
bam-7218	26	10	to	to	PART
bam-7218	26	11	deliver	deliver	VERB
bam-7218	26	12	major	major	ADJ
bam-7218	26	13	contributions	contribution	NOUN
bam-7218	26	14	to	to	ADP
bam-7218	26	15	the	the	DET
bam-7218	26	16	understanding	understanding	NOUN
bam-7218	26	17	and	and	CCONJ
bam-7218	26	18	treatment	treatment	NOUN
bam-7218	26	19	of	of	ADP
bam-7218	26	20	muscular	muscular	ADJ
bam-7218	26	21	muscle	muscle	NOUN
bam-7218	26	22	diseases	disease	NOUN
bam-7218	26	23	.	.	PUNCT
bam-7218	27	1	moreover	moreover	ADV
bam-7218	27	2	,	,	PUNCT
bam-7218	27	3	there	there	PRON
bam-7218	27	4	is	be	VERB
bam-7218	27	5	an	an	DET
bam-7218	27	6	urgent	urgent	ADJ
bam-7218	27	7	need	need	NOUN
bam-7218	27	8	to	to	PART
bam-7218	27	9	integrate	integrate	VERB
bam-7218	27	10	all	all	DET
bam-7218	27	11	the	the	DET
bam-7218	27	12	themes	theme	NOUN
bam-7218	27	13	involved	involve	VERB
bam-7218	27	14	in	in	ADP
bam-7218	27	15	myology	myology	NOUN
bam-7218	27	16	research	research	NOUN
bam-7218	27	17	in	in	ADP
bam-7218	27	18	a	a	DET
bam-7218	27	19	setting	setting	NOUN
bam-7218	27	20	that	that	PRON
bam-7218	27	21	promotes	promote	VERB
bam-7218	27	22	discussion	discussion	NOUN
bam-7218	27	23	.	.	PUNCT
bam-7218	28	1	this	this	PRON
bam-7218	28	2	will	will	AUX
bam-7218	28	3	certainly	certainly	ADV
bam-7218	28	4	attract	attract	VERB
bam-7218	28	5	a	a	DET
bam-7218	28	6	broader	broad	ADJ
bam-7218	28	7	audience	audience	NOUN
bam-7218	28	8	and	and	CCONJ
bam-7218	28	9	contribute	contribute	VERB
bam-7218	28	10	to	to	ADP
bam-7218	28	11	scientific	scientific	ADJ
bam-7218	28	12	crossfertilization	crossfertilization	NOUN
bam-7218	28	13	in	in	ADP
bam-7218	28	14	this	this	DET
bam-7218	28	15	exciting	exciting	ADJ
bam-7218	28	16	area	area	NOUN
bam-7218	28	17	of	of	ADP
bam-7218	28	18	research	research	NOUN
bam-7218	28	19	.	.	PUNCT
bam-7218	29	1	on	on	ADP
bam-7218	29	2	the	the	DET
bam-7218	29	3	first	first	ADJ
bam-7218	29	4	evening	evening	NOUN
bam-7218	29	5	of	of	ADP
bam-7218	29	6	the	the	DET
bam-7218	29	7	meeting	meeting	NOUN
bam-7218	29	8	,	,	PUNCT
bam-7218	29	9	young	young	ADJ
bam-7218	29	10	scientists	scientist	NOUN
bam-7218	29	11	organized	organize	VERB
bam-7218	29	12	three	three	NUM
bam-7218	29	13	roundtable	roundtable	ADJ
bam-7218	29	14	discussions	discussion	NOUN
bam-7218	29	15	during	during	ADP
bam-7218	29	16	which	which	PRON
bam-7218	29	17	trainees	trainee	NOUN
bam-7218	29	18	discussed	discuss	VERB
bam-7218	29	19	about	about	ADP
bam-7218	29	20	issues	issue	NOUN
bam-7218	29	21	and	and	CCONJ
bam-7218	29	22	new	new	ADJ
bam-7218	29	23	ideas	idea	NOUN
bam-7218	29	24	concerning	concern	VERB
bam-7218	29	25	gene	gene	NOUN
bam-7218	29	26	therapy	therapy	NOUN
bam-7218	29	27	,	,	PUNCT
bam-7218	29	28	stem	stem	NOUN
bam-7218	29	29	cells	cell	NOUN
bam-7218	29	30	e	e	NOUN
bam-7218	29	31	bioengineering	bioengineering	NOUN
bam-7218	29	32	;	;	PUNCT
bam-7218	29	33	metabolism	metabolism	NOUN
bam-7218	29	34	,	,	PUNCT
bam-7218	29	35	exercise	exercise	VERB
bam-7218	29	36	and	and	CCONJ
bam-7218	29	37	signaling	signal	VERB
bam-7218	29	38	pathways	pathway	NOUN
bam-7218	29	39	in	in	ADP
bam-7218	29	40	muscle	muscle	NOUN
bam-7218	29	41	wasting	waste	VERB
bam-7218	29	42	;	;	PUNCT
bam-7218	29	43	muscular	muscular	ADJ
bam-7218	29	44	dystrophies	dystrophy	NOUN
bam-7218	29	45	.	.	PUNCT
bam-7218	30	1	moderated	moderate	VERB
bam-7218	30	2	by	by	ADP
bam-7218	30	3	the	the	DET
bam-7218	30	4	invited	invite	VERB
bam-7218	30	5	speakers	speaker	NOUN
bam-7218	30	6	or	or	CCONJ
bam-7218	30	7	selected	select	VERB
bam-7218	30	8	members	member	NOUN
bam-7218	30	9	of	of	ADP
bam-7218	30	10	the	the	DET
bam-7218	30	11	iim	iim	PROPN
bam-7218	30	12	scientific	scientific	ADJ
bam-7218	30	13	committee	committee	NOUN
bam-7218	30	14	,	,	PUNCT
bam-7218	30	15	the	the	DET
bam-7218	30	16	roundtables	roundtable	NOUN
bam-7218	30	17	offered	offer	VERB
bam-7218	30	18	an	an	DET
bam-7218	30	19	ideal	ideal	ADJ
bam-7218	30	20	opportunity	opportunity	NOUN
bam-7218	30	21	to	to	PART
bam-7218	30	22	discuss	discuss	VERB
bam-7218	30	23	muscle	muscle	NOUN
bam-7218	30	24	research	research	NOUN
bam-7218	30	25	in	in	ADP
bam-7218	30	26	an	an	DET
bam-7218	30	27	informal	informal	ADJ
bam-7218	30	28	way	way	NOUN
bam-7218	30	29	,	,	PUNCT
bam-7218	30	30	over	over	ADP
bam-7218	30	31	food	food	NOUN
bam-7218	30	32	and	and	CCONJ
bam-7218	30	33	drinks	drink	NOUN
bam-7218	30	34	provided	provide	VERB
bam-7218	30	35	by	by	ADP
bam-7218	30	36	local	local	ADJ
bam-7218	30	37	producers	producer	NOUN
bam-7218	30	38	.	.	PUNCT
bam-7218	31	1	on	on	ADP
bam-7218	31	2	the	the	DET
bam-7218	31	3	second	second	ADJ
bam-7218	31	4	evening	evening	NOUN
bam-7218	31	5	of	of	ADP
bam-7218	31	6	the	the	DET
bam-7218	31	7	meeting	meeting	NOUN
bam-7218	31	8	,	,	PUNCT
bam-7218	31	9	guided	guide	VERB
bam-7218	31	10	tours	tour	NOUN
bam-7218	31	11	were	be	AUX
bam-7218	31	12	organized	organize	VERB
bam-7218	31	13	to	to	ADP
bam-7218	31	14	the	the	DET
bam-7218	31	15	saint	saint	PROPN
bam-7218	31	16	francis	francis	PROPN
bam-7218	31	17	basilica	basilica	PROPN
bam-7218	31	18	famous	famous	ADJ
bam-7218	31	19	for	for	ADP
bam-7218	31	20	its	its	PRON
bam-7218	31	21	giotto	giotto	NOUN
bam-7218	31	22	’s	’s	PART
bam-7218	31	23	frescoes	fresco	NOUN
bam-7218	31	24	and	and	CCONJ
bam-7218	31	25	to	to	ADP
bam-7218	31	26	the	the	DET
bam-7218	31	27	ancient	ancient	ADJ
bam-7218	31	28	roman	roman	PROPN
bam-7218	31	29	forum	forum	PROPN
bam-7218	31	30	.	.	PUNCT
bam-7218	32	1	the	the	DET
bam-7218	32	2	evening	evening	NOUN
bam-7218	32	3	concluded	conclude	VERB
bam-7218	32	4	with	with	ADP
bam-7218	32	5	a	a	DET
bam-7218	32	6	medieval	medieval	ADJ
bam-7218	32	7	show	show	NOUN
bam-7218	32	8	and	and	CCONJ
bam-7218	32	9	dinner	dinner	NOUN
bam-7218	32	10	in	in	ADP
bam-7218	32	11	the	the	DET
bam-7218	32	12	historic	historic	ADJ
bam-7218	32	13	sala	sala	PROPN
bam-7218	32	14	delle	delle	PROPN
bam-7218	32	15	volte	volte	PROPN
bam-7218	32	16	.	.	PUNCT
bam-7218	33	1	finally	finally	ADV
bam-7218	33	2	,	,	PUNCT
bam-7218	33	3	an	an	DET
bam-7218	33	4	award	award	NOUN
bam-7218	33	5	cerimony	cerimony	NOUN
bam-7218	33	6	was	be	AUX
bam-7218	33	7	held	hold	VERB
bam-7218	33	8	on	on	ADP
bam-7218	33	9	the	the	DET
bam-7218	33	10	last	last	ADJ
bam-7218	33	11	evening	evening	NOUN
bam-7218	33	12	of	of	ADP
bam-7218	33	13	the	the	DET
bam-7218	33	14	meeting	meeting	NOUN
bam-7218	33	15	to	to	PART
bam-7218	33	16	congratulate	congratulate	VERB
bam-7218	33	17	martina	martina	PROPN
bam-7218	33	18	baraldo	baraldo	PROPN
bam-7218	33	19	,	,	PUNCT
bam-7218	33	20	ester	ester	NOUN
bam-7218	33	21	sara	sara	PROPN
bam-7218	33	22	di	di	PROPN
bam-7218	33	23	filippo	filippo	PROPN
bam-7218	33	24	,	,	PUNCT
bam-7218	33	25	anäis	anäis	PROPN
bam-7218	33	26	franco	franco	PROPN
bam-7218	33	27	romero	romero	PROPN
bam-7218	33	28	and	and	CCONJ
bam-7218	33	29	alessandra	alessandra	PROPN
bam-7218	33	30	pasut	pasut	PROPN
bam-7218	33	31	,	,	PUNCT
bam-7218	33	32	winners	winner	NOUN
bam-7218	33	33	of	of	ADP
bam-7218	33	34	prices	price	NOUN
bam-7218	33	35	for	for	ADP
bam-7218	33	36	best	good	ADJ
bam-7218	33	37	oral	oral	ADJ
bam-7218	33	38	and	and	CCONJ
bam-7218	33	39	poster	poster	NOUN
bam-7218	33	40	presentations	presentation	NOUN
bam-7218	33	41	selected	select	VERB
bam-7218	33	42	by	by	ADP
bam-7218	33	43	an	an	DET
bam-7218	33	44	international	international	ADJ
bam-7218	33	45	panel	panel	NOUN
bam-7218	33	46	composed	compose	VERB
bam-7218	33	47	by	by	ADP
bam-7218	33	48	the	the	DET
bam-7218	33	49	invited	invite	VERB
bam-7218	33	50	speakers	speaker	NOUN
bam-7218	33	51	and	and	CCONJ
bam-7218	33	52	members	member	NOUN
bam-7218	33	53	of	of	ADP
bam-7218	33	54	the	the	DET
bam-7218	33	55	iim	iim	PROPN
bam-7218	33	56	scientific	scientific	ADJ
bam-7218	33	57	committee	committee	NOUN
bam-7218	33	58	.	.	PUNCT
bam-7218	34	1	since	since	SCONJ
bam-7218	34	2	2014	2014	NUM
bam-7218	34	3	,	,	PUNCT
bam-7218	34	4	the	the	DET
bam-7218	34	5	collections	collection	NOUN
bam-7218	34	6	of	of	ADP
bam-7218	34	7	abstracts	abstract	NOUN
bam-7218	34	8	presented	present	VERB
bam-7218	34	9	to	to	ADP
bam-7218	34	10	the	the	DET
bam-7218	34	11	annual	annual	ADJ
bam-7218	34	12	iim	iim	NOUN
bam-7218	34	13	meeting	meeting	NOUN
bam-7218	34	14	are	be	AUX
bam-7218	34	15	e	e	VERB
bam-7218	34	16	-	-	VERB
bam-7218	34	17	published	publish	VERB
bam-7218	34	18	in	in	ADP
bam-7218	34	19	the	the	DET
bam-7218	34	20	european	european	PROPN
bam-7218	34	21	journal	journal	PROPN
bam-7218	34	22	of	of	ADP
bam-7218	34	23	translational	translational	ADJ
bam-7218	34	24	myology	myology	NOUN
bam-7218	34	25	,	,	PUNCT
bam-7218	34	26	an	an	DET
bam-7218	34	27	open	open	ADJ
bam-7218	34	28	source	source	NOUN
bam-7218	34	29	journal	journal	NOUN
bam-7218	34	30	whose	whose	DET
bam-7218	34	31	contents	content	NOUN
bam-7218	34	32	are	be	AUX
bam-7218	34	33	retrievable	retrievable	ADJ
bam-7218	34	34	in	in	ADP
bam-7218	34	35	pubmed	pubmed	PROPN
bam-7218	34	36	from	from	ADP
bam-7218	34	37	2014	2014	NUM
bam-7218	34	38	and	and	CCONJ
bam-7218	34	39	more	more	ADV
bam-7218	34	40	recently	recently	ADV
bam-7218	34	41	in	in	ADP
bam-7218	34	42	the	the	DET
bam-7218	34	43	web	web	NOUN
bam-7218	34	44	of	of	ADP
bam-7218	34	45	science	science	NOUN
bam-7218	34	46	.	.	PUNCT
bam-7218	35	1	the	the	DET
bam-7218	35	2	collections	collection	NOUN
bam-7218	35	3	of	of	ADP
bam-7218	35	4	abstracts	abstract	NOUN
bam-7218	35	5	provide	provide	VERB
bam-7218	35	6	information	information	NOUN
bam-7218	35	7	on	on	ADP
bam-7218	35	8	research	research	NOUN
bam-7218	35	9	lines	line	NOUN
bam-7218	35	10	active	active	ADJ
bam-7218	35	11	on	on	ADP
bam-7218	35	12	basic	basic	ADJ
bam-7218	35	13	and	and	CCONJ
bam-7218	35	14	translational	translational	ADJ
bam-7218	35	15	myology	myology	NOUN
bam-7218	35	16	.	.	PUNCT
bam-7218	36	1	1	1	NUM
bam-7218	36	2	-	-	SYM
bam-7218	36	3	4	4	NUM
bam-7218	36	4	in	in	ADP
bam-7218	36	5	ejtm	ejtm	NOUN
bam-7218	36	6	more	more	ADV
bam-7218	36	7	clinically	clinically	ADV
bam-7218	36	8	oriented	orient	VERB
bam-7218	36	9	myology	myology	NOUN
bam-7218	36	10	research	research	NOUN
bam-7218	36	11	activities	activity	NOUN
bam-7218	36	12	,	,	PUNCT
bam-7218	36	13	related	relate	VERB
bam-7218	36	14	to	to	ADP
bam-7218	36	15	muscle	muscle	NOUN
bam-7218	36	16	repair	repair	NOUN
bam-7218	36	17	and	and	CCONJ
bam-7218	36	18	rehabilitation	rehabilitation	NOUN
bam-7218	36	19	,	,	PUNCT
bam-7218	36	20	are	be	AUX
bam-7218	36	21	published	publish	VERB
bam-7218	36	22	in	in	ADP
bam-7218	36	23	the	the	DET
bam-7218	36	24	collections	collection	NOUN
bam-7218	36	25	of	of	ADP
bam-7218	36	26	abstracts	abstract	NOUN
bam-7218	36	27	of	of	ADP
bam-7218	36	28	the	the	DET
bam-7218	36	29	paduamuscledays	paduamuscleday	NOUN
bam-7218	36	30	,	,	PUNCT
bam-7218	36	31	a	a	DET
bam-7218	36	32	series	series	NOUN
bam-7218	36	33	of	of	ADP
bam-7218	36	34	meetings	meeting	NOUN
bam-7218	36	35	that	that	PRON
bam-7218	36	36	held	hold	VERB
bam-7218	36	37	twice	twice	DET
bam-7218	36	38	a	a	DET
bam-7218	36	39	year	year	NOUN
bam-7218	36	40	in	in	ADP
bam-7218	36	41	euganei	euganei	ADJ
bam-7218	36	42	hills	hill	NOUN
bam-7218	36	43	and	and	CCONJ
bam-7218	36	44	padua	padua	PROPN
bam-7218	36	45	,	,	PUNCT
bam-7218	36	46	italy	italy	PROPN
bam-7218	36	47	.	.	PUNCT
bam-7218	37	1	5	5	NUM
bam-7218	37	2	-	-	SYM
bam-7218	37	3	9	9	NUM
bam-7218	37	4	ejtm	ejtm	NOUN
bam-7218	37	5	is	be	AUX
bam-7218	37	6	also	also	ADV
bam-7218	37	7	publishing	publish	VERB
bam-7218	37	8	articles	article	NOUN
bam-7218	37	9	and	and	CCONJ
bam-7218	37	10	reviews	review	NOUN
bam-7218	37	11	submitted	submit	VERB
bam-7218	37	12	by	by	ADP
bam-7218	37	13	researchers	researcher	NOUN
bam-7218	37	14	of	of	ADP
bam-7218	37	15	the	the	DET
bam-7218	37	16	italian	italian	ADJ
bam-7218	37	17	community	community	NOUN
bam-7218	37	18	of	of	ADP
bam-7218	37	19	myologists	myologist	NOUN
bam-7218	37	20	.	.	PUNCT
bam-7218	38	1	10	10	NUM
bam-7218	38	2	-	-	SYM
bam-7218	38	3	30	30	NUM
bam-7218	38	4	here	here	ADV
bam-7218	38	5	,	,	PUNCT
bam-7218	38	6	4	4	NUM
bam-7218	38	7	the	the	DET
bam-7218	38	8	abstracts	abstract	NOUN
bam-7218	38	9	of	of	ADP
bam-7218	38	10	the	the	DET
bam-7218	38	11	14	14	NUM
bam-7218	38	12	th	th	NUM
bam-7218	38	13	iim	iim	NOUN
bam-7218	38	14	meeting	meeting	NOUN
bam-7218	38	15	show	show	VERB
bam-7218	38	16	that	that	SCONJ
bam-7218	38	17	results	result	NOUN
bam-7218	38	18	of	of	ADP
bam-7218	38	19	basic	basic	ADJ
bam-7218	38	20	,	,	PUNCT
bam-7218	38	21	translation	translation	NOUN
bam-7218	38	22	and	and	CCONJ
bam-7218	38	23	early	early	ADJ
bam-7218	38	24	clinical	clinical	ADJ
bam-7218	38	25	studies	study	NOUN
bam-7218	38	26	for	for	ADP
bam-7218	38	27	many	many	ADJ
bam-7218	38	28	topics	topic	NOUN
bam-7218	38	29	are	be	AUX
bam-7218	38	30	mature	mature	ADJ
bam-7218	38	31	to	to	PART
bam-7218	38	32	be	be	AUX
bam-7218	38	33	translated	translate	VERB
bam-7218	38	34	to	to	ADP
bam-7218	38	35	clinical	clinical	ADJ
bam-7218	38	36	application	application	NOUN
bam-7218	38	37	.	.	PUNCT
bam-7218	39	1	however	however	ADV
bam-7218	39	2	,	,	PUNCT
bam-7218	39	3	further	further	ADJ
bam-7218	39	4	studies	study	NOUN
bam-7218	39	5	will	will	AUX
bam-7218	39	6	be	be	AUX
bam-7218	39	7	necessary	necessary	ADJ
bam-7218	39	8	to	to	PART
bam-7218	39	9	validate	validate	VERB
bam-7218	39	10	clinical	clinical	ADJ
bam-7218	39	11	relevance	relevance	NOUN
bam-7218	39	12	of	of	ADP
bam-7218	39	13	these	these	DET
bam-7218	39	14	preliminary	preliminary	ADJ
bam-7218	39	15	results	result	NOUN
bam-7218	39	16	.	.	PUNCT
bam-7218	40	1	hopefully	hopefully	ADV
bam-7218	40	2	,	,	PUNCT
bam-7218	40	3	public	public	ADJ
bam-7218	40	4	and	and	CCONJ
bam-7218	40	5	private	private	ADJ
bam-7218	40	6	granting	grant	VERB
bam-7218	40	7	agencies	agency	NOUN
bam-7218	40	8	will	will	AUX
bam-7218	40	9	provide	provide	VERB
bam-7218	40	10	the	the	DET
bam-7218	40	11	funds	fund	NOUN
bam-7218	40	12	to	to	PART
bam-7218	40	13	support	support	VERB
bam-7218	40	14	young	young	ADJ
bam-7218	40	15	and	and	CCONJ
bam-7218	40	16	expert	expert	ADJ
bam-7218	40	17	researchers	researcher	NOUN
bam-7218	40	18	needed	need	VERB
bam-7218	40	19	to	to	PART
bam-7218	40	20	implement	implement	VERB
bam-7218	40	21	sound	sound	ADJ
bam-7218	40	22	clinical	clinical	ADJ
bam-7218	40	23	trials	trial	NOUN
bam-7218	40	24	.	.	PUNCT
bam-7218	41	1	author	author	NOUN
bam-7218	41	2	’s	’s	PART
bam-7218	41	3	contributions	contribution	NOUN
bam-7218	41	4	authors	author	NOUN
bam-7218	41	5	equally	equally	ADV
bam-7218	41	6	contributed	contribute	VERB
bam-7218	41	7	design	design	NOUN
bam-7218	41	8	,	,	PUNCT
bam-7218	41	9	write	write	VERB
bam-7218	41	10	and	and	CCONJ
bam-7218	41	11	approved	approve	VERB
bam-7218	41	12	the	the	DET
bam-7218	41	13	proofs	proof	NOUN
bam-7218	41	14	of	of	ADP
bam-7218	41	15	the	the	DET
bam-7218	41	16	manuscript	manuscript	NOUN
bam-7218	41	17	.	.	PUNCT
bam-7218	42	1	acknowledgments	acknowledgment	NOUN
bam-7218	42	2	this	this	DET
bam-7218	42	3	typescript	typescript	NOUN
bam-7218	42	4	was	be	AUX
bam-7218	42	5	sponsored	sponsor	VERB
bam-7218	42	6	by	by	ADP
bam-7218	42	7	the	the	DET
bam-7218	42	8	a&c	a&c	PROPN
bam-7218	42	9	m	m	PROPN
bam-7218	42	10	-	-	PROPN
bam-7218	42	11	c	c	PROPN
bam-7218	42	12	foundation	foundation	NOUN
bam-7218	42	13	for	for	ADP
bam-7218	42	14	translational	translational	ADJ
bam-7218	42	15	myology	myology	NOUN
bam-7218	42	16	,	,	PUNCT
bam-7218	42	17	padova	padova	PROPN
bam-7218	42	18	,	,	PUNCT
bam-7218	42	19	italy	italy	PROPN
bam-7218	42	20	.	.	PUNCT
bam-7218	43	1	conflict	conflict	NOUN
bam-7218	43	2	of	of	ADP
bam-7218	43	3	interest	interest	NOUN
bam-7218	43	4	none	none	NOUN
bam-7218	43	5	of	of	ADP
bam-7218	43	6	the	the	DET
bam-7218	43	7	authors	author	NOUN
bam-7218	43	8	have	have	VERB
bam-7218	43	9	conflicts	conflict	NOUN
bam-7218	43	10	of	of	ADP
bam-7218	43	11	interests	interest	NOUN
bam-7218	43	12	.	.	PUNCT
bam-7218	44	1	ethical	ethical	ADJ
bam-7218	44	2	publication	publication	NOUN
bam-7218	44	3	statement	statement	NOUN
bam-7218	44	4	authors	author	NOUN
bam-7218	44	5	confirm	confirm	VERB
bam-7218	44	6	that	that	SCONJ
bam-7218	44	7	they	they	PRON
bam-7218	44	8	have	have	AUX
bam-7218	44	9	read	read	VERB
bam-7218	44	10	the	the	DET
bam-7218	44	11	journal	journal	NOUN
bam-7218	44	12	’s	’s	PART
bam-7218	44	13	position	position	NOUN
bam-7218	44	14	on	on	ADP
bam-7218	44	15	issues	issue	NOUN
bam-7218	44	16	involved	involve	VERB
bam-7218	44	17	in	in	ADP
bam-7218	44	18	ethical	ethical	ADJ
bam-7218	44	19	publication	publication	NOUN
bam-7218	44	20	and	and	CCONJ
bam-7218	44	21	affirm	affirm	NOUN
bam-7218	44	22	that	that	SCONJ
bam-7218	44	23	this	this	DET
bam-7218	44	24	report	report	NOUN
bam-7218	44	25	is	be	AUX
bam-7218	44	26	consistent	consistent	ADJ
bam-7218	44	27	with	with	ADP
bam-7218	44	28	those	those	DET
bam-7218	44	29	guidelines	guideline	NOUN
bam-7218	44	30	.	.	PUNCT
bam-7218	45	1	corresponding	correspond	VERB
bam-7218	45	2	authors	author	NOUN
bam-7218	45	3	davide	davide	PROPN
bam-7218	45	4	gabellini	gabellini	PROPN
bam-7218	45	5	,	,	PUNCT
bam-7218	45	6	gene	gene	NOUN
bam-7218	45	7	expression	expression	NOUN
bam-7218	45	8	and	and	CCONJ
bam-7218	45	9	muscular	muscular	ADJ
bam-7218	45	10	dystrophy	dystrophy	NOUN
bam-7218	45	11	unit	unit	NOUN
bam-7218	45	12	,	,	PUNCT
bam-7218	45	13	division	division	NOUN
bam-7218	45	14	of	of	ADP
bam-7218	45	15	genetics	genetic	NOUN
bam-7218	45	16	and	and	CCONJ
bam-7218	45	17	cell	cell	NOUN
bam-7218	45	18	biology	biology	NOUN
bam-7218	45	19	,	,	PUNCT
bam-7218	45	20	irccs	ircc	VERB
bam-7218	45	21	san	san	PROPN
bam-7218	45	22	raffaele	raffaele	PROPN
bam-7218	45	23	scientific	scientific	PROPN
bam-7218	45	24	institute	institute	PROPN
bam-7218	45	25	,	,	PUNCT
bam-7218	45	26	milano	milano	PROPN
bam-7218	45	27	,	,	PUNCT
bam-7218	45	28	italy	italy	PROPN
bam-7218	45	29	.	.	PUNCT
bam-7218	46	1	email	email	NOUN
bam-7218	46	2	:	:	PUNCT
bam-7218	46	3	gabellini.davide@hsr.it	gabellini.davide@hsr.it	PROPN
bam-7218	46	4	antonio	antonio	PROPN
bam-7218	46	5	musarò	musarò	PROPN
bam-7218	46	6	,	,	PUNCT
bam-7218	46	7	dahfmo	dahfmo	NOUN
bam-7218	46	8	-	-	PUNCT
bam-7218	46	9	unit	unit	NOUN
bam-7218	46	10	of	of	ADP
bam-7218	46	11	histology	histology	NOUN
bam-7218	46	12	and	and	CCONJ
bam-7218	46	13	medical	medical	ADJ
bam-7218	46	14	embryology	embryology	NOUN
bam-7218	46	15	,	,	PUNCT
bam-7218	46	16	laboratory	laboratory	NOUN
bam-7218	46	17	affiliated	affiliate	VERB
bam-7218	46	18	to	to	ADP
bam-7218	46	19	istituto	istituto	PROPN
bam-7218	46	20	pasteur	pasteur	PROPN
bam-7218	46	21	italia	italia	PROPN
bam-7218	46	22	–	–	PUNCT
bam-7218	46	23	fondazione	fondazione	PROPN
bam-7218	46	24	cenci	cenci	PROPN
bam-7218	46	25	bolognetti	bolognetti	PROPN
bam-7218	46	26	,	,	PUNCT
bam-7218	46	27	sapienza	sapienza	PROPN
bam-7218	46	28	university	university	NOUN
bam-7218	46	29	;	;	PUNCT
bam-7218	46	30	center	center	NOUN
bam-7218	46	31	for	for	ADP
bam-7218	46	32	life	life	NOUN
bam-7218	46	33	nano	nano	NOUN
bam-7218	46	34	science@sapienza	science@sapienza	PROPN
bam-7218	46	35	,	,	PUNCT
bam-7218	46	36	iit	iit	PROPN
bam-7218	46	37	,	,	PUNCT
bam-7218	46	38	rome	rome	PROPN
bam-7218	46	39	,	,	PUNCT
bam-7218	46	40	italy	italy	PROPN
bam-7218	46	41	.	.	PUNCT
bam-7218	47	1	e	e	X
bam-7218	47	2	-	-	NOUN
bam-7218	47	3	mail	mail	NOUN
bam-7218	47	4	:	:	PUNCT
bam-7218	47	5	antonio.musaro@uniroma1.it	antonio.musaro@uniroma1.it	NOUN
bam-7218	47	6	references	reference	NOUN
bam-7218	47	7	1	1	NUM
bam-7218	47	8	.	.	PUNCT
bam-7218	48	1	editors	editor	NOUN
bam-7218	48	2	.	.	PUNCT
bam-7218	49	1	xi	xi	X
bam-7218	49	2	iim	iim	PROPN
bam-7218	49	3	meeting	meeting	NOUN
bam-7218	49	4	2	2	NUM
bam-7218	49	5	-	-	SYM
bam-7218	49	6	5	5	NUM
bam-7218	49	7	october	october	PROPN
bam-7218	49	8	2014borgo	2014borgo	PROPN
bam-7218	49	9	san	san	PROPN
bam-7218	49	10	luigi	luigi	PROPN
bam-7218	49	11	,	,	PUNCT
bam-7218	49	12	monteriggioni	monteriggioni	PROPN
bam-7218	49	13	,	,	PUNCT
bam-7218	49	14	siena	siena	PROPN
bam-7218	49	15	(	(	PUNCT
bam-7218	49	16	italy	italy	PROPN
bam-7218	49	17	)	)	PUNCT
bam-7218	49	18	,	,	PUNCT
bam-7218	49	19	abstracts	abstract	VERB
bam-7218	49	20	.	.	PUNCT
bam-7218	50	1	eur	eur	PROPN
bam-7218	50	2	j	j	PROPN
bam-7218	50	3	transl	transl	PROPN
bam-7218	50	4	myol	myol	NOUN
bam-7218	50	5	2014;24:227	2014;24:227	PROPN
bam-7218	50	6	-	-	SYM
bam-7218	50	7	60	60	NUM
bam-7218	50	8	.	.	PUNCT
bam-7218	51	1	mailto:gabellini.davide@hsr.it	mailto:gabellini.davide@hsr.it	DET
bam-7218	51	2	mailto:antonio.musaro@uniroma1.it	mailto:antonio.musaro@uniroma1.it	PROPN
bam-7218	51	3	14	14	NUM
bam-7218	51	4	th	th	NUM
bam-7218	51	5	iiim	iiim	NOUN
bam-7218	51	6	meeting	meeting	NOUN
bam-7218	51	7	,	,	PUNCT
bam-7218	51	8	assisi	assisi	PROPN
bam-7218	51	9	,	,	PUNCT
bam-7218	51	10	italy	italy	PROPN
bam-7218	51	11	october	october	PROPN
bam-7218	51	12	12	12	NUM
bam-7218	51	13	-	-	SYM
bam-7218	51	14	15	15	NUM
bam-7218	51	15	2017	2017	NUM
bam-7218	51	16	eur	eur	PROPN
bam-7218	51	17	j	j	PROPN
bam-7218	51	18	transl	transl	PROPN
bam-7218	51	19	myol	myol	ADV
bam-7218	51	20	27	27	NUM
bam-7218	51	21	(	(	PUNCT
bam-7218	51	22	4	4	NUM
bam-7218	51	23	):	):	SYM
bam-7218	51	24	185	185	NUM
bam-7218	51	25	-	-	SYM
bam-7218	51	26	224	224	NUM
bam-7218	51	27	187	187	NUM
bam-7218	51	28	2	2	NUM
bam-7218	51	29	.	.	PUNCT
bam-7218	51	30	editors	editor	NOUN
bam-7218	51	31	.	.	PUNCT
bam-7218	52	1	xii	xii	PROPN
bam-7218	52	2	iim	iim	NOUN
bam-7218	52	3	myology	myology	NOUN
bam-7218	52	4	meeting	meeting	NOUN
bam-7218	52	5	,	,	PUNCT
bam-7218	52	6	october	october	PROPN
bam-7218	52	7	1st	1st	NOUN
bam-7218	52	8	to	to	ADP
bam-7218	52	9	4th	4th	ADJ
bam-7218	52	10	2015	2015	NUM
bam-7218	52	11	reggio	reggio	PROPN
bam-7218	52	12	emilia	emilia	PROPN
bam-7218	52	13	(	(	PUNCT
bam-7218	52	14	italy	italy	PROPN
bam-7218	52	15	)	)	PUNCT
bam-7218	52	16	,	,	PUNCT
bam-7218	52	17	abstracts	abstract	VERB
bam-7218	52	18	.	.	PUNCT
bam-7218	53	1	eur	eur	PROPN
bam-7218	53	2	j	j	PROPN
bam-7218	53	3	transl	transl	PROPN
bam-7218	53	4	myol	myol	NOUN
bam-7218	53	5	2016;26:2–24	2016;26:2–24	NUM
bam-7218	53	6	.	.	PUNCT
bam-7218	54	1	3	3	X
bam-7218	54	2	.	.	NUM
bam-7218	54	3	editors	editor	NOUN
bam-7218	54	4	.	.	PUNCT
bam-7218	55	1	xiii	xiii	PROPN
bam-7218	55	2	iim	iim	PROPN
bam-7218	55	3	myology	myology	NOUN
bam-7218	55	4	meeting	meeting	NOUN
bam-7218	55	5	,	,	PUNCT
bam-7218	55	6	october	october	PROPN
bam-7218	55	7	13	13	NUM
bam-7218	55	8	–	–	PUNCT
bam-7218	55	9	16	16	NUM
bam-7218	55	10	,	,	PUNCT
bam-7218	55	11	2016	2016	NUM
bam-7218	55	12	assisi	assisi	NOUN
bam-7218	55	13	,	,	PUNCT
bam-7218	55	14	perugia	perugia	PROPN
bam-7218	55	15	(	(	PUNCT
bam-7218	55	16	italy	italy	PROPN
bam-7218	55	17	)	)	PUNCT
bam-7218	55	18	,	,	PUNCT
bam-7218	55	19	abstracts	abstract	VERB
bam-7218	55	20	2017;27:2	2017;27:2	NUM
bam-7218	55	21	-	-	SYM
bam-7218	55	22	32	32	NUM
bam-7218	55	23	.	.	PUNCT
bam-7218	56	1	4	4	NUM
bam-7218	56	2	.	.	NUM
bam-7218	56	3	editors	editor	NOUN
bam-7218	56	4	.	.	PUNCT
bam-7218	57	1	14	14	NUM
bam-7218	57	2	th	th	NUM
bam-7218	57	3	iim	iim	NOUN
bam-7218	57	4	meeting	meeting	NOUN
bam-7218	57	5	,	,	PUNCT
bam-7218	57	6	october	october	PROPN
bam-7218	57	7	12–15	12–15	NUM
bam-7218	57	8	,	,	PUNCT
bam-7218	57	9	2017	2017	NUM
bam-7218	57	10	assisi	assisi	NOUN
bam-7218	57	11	,	,	PUNCT
bam-7218	57	12	perugia	perugia	PROPN
bam-7218	57	13	(	(	PUNCT
bam-7218	57	14	italy	italy	PROPN
bam-7218	57	15	)	)	PUNCT
bam-7218	57	16	,	,	PUNCT
bam-7218	57	17	abstracts	abstract	VERB
bam-7218	57	18	.	.	PUNCT
bam-7218	58	1	eur	eur	PROPN
bam-7218	58	2	j	j	PROPN
bam-7218	58	3	transl	transl	PROPN
bam-7218	58	4	myol	myol	PROPN
bam-7218	58	5	2017;27	2017;27	PROPN
bam-7218	58	6	,	,	PUNCT
bam-7218	58	7	in	in	ADP
bam-7218	58	8	press	press	NOUN
bam-7218	58	9	.	.	PUNCT
bam-7218	59	1	5	5	X
bam-7218	59	2	.	.	X
bam-7218	59	3	editors	editor	NOUN
bam-7218	59	4	.	.	PUNCT
bam-7218	60	1	abstracts	abstract	NOUN
bam-7218	60	2	of	of	ADP
bam-7218	60	3	the	the	DET
bam-7218	60	4	2017spring	2017spring	NUM
bam-7218	60	5	paduamuscledays	paduamuscleday	NOUN
bam-7218	60	6	,	,	PUNCT
bam-7218	60	7	march	march	PROPN
bam-7218	60	8	23–25	23–25	NUM
bam-7218	60	9	,	,	PUNCT
bam-7218	60	10	montegrotto	montegrotto	PROPN
bam-7218	60	11	&	&	CCONJ
bam-7218	60	12	padua	padua	PROPN
bam-7218	60	13	(	(	PUNCT
bam-7218	60	14	italy	italy	PROPN
bam-7218	60	15	)	)	PUNCT
bam-7218	60	16	,	,	PUNCT
bam-7218	60	17	eur	eur	PROPN
bam-7218	60	18	j	j	PROPN
bam-7218	60	19	transl	transl	PROPN
bam-7218	60	20	myol	myol	NOUN
bam-7218	60	21	2017;27:81	2017;27:81	NUM
bam-7218	60	22	-	-	SYM
bam-7218	60	23	112	112	NUM
bam-7218	60	24	.	.	PUNCT
bam-7218	61	1	6	6	NUM
bam-7218	61	2	.	.	PUNCT
bam-7218	61	3	carraro	carraro	PROPN
bam-7218	61	4	u.	u.	PROPN
bam-7218	61	5	2017spring	2017spring	PROPN
bam-7218	61	6	paduamuscledays	paduamuscleday	NOUN
bam-7218	61	7	,	,	PUNCT
bam-7218	61	8	roots	root	NOUN
bam-7218	61	9	and	and	CCONJ
bam-7218	61	10	byproducts	byproduct	NOUN
bam-7218	61	11	.	.	PUNCT
bam-7218	62	1	eur	eur	PROPN
bam-7218	62	2	j	j	PROPN
bam-7218	62	3	transl	transl	PROPN
bam-7218	62	4	myol	myol	NOUN
bam-7218	62	5	.	.	PUNCT
bam-7218	63	1	2017	2017	NUM
bam-7218	63	2	;	;	PUNCT
bam-7218	63	3	27:6810	27:6810	X
bam-7218	63	4	.	.	X
bam-7218	64	1	doi	doi	NOUN
bam-7218	64	2	:	:	PUNCT
bam-7218	64	3	10.4081	10.4081	NUM
bam-7218	64	4	/	/	SYM
bam-7218	64	5	ejtm.2017.6810	ejtm.2017.6810	PROPN
bam-7218	64	6	.	.	PUNCT
bam-7218	65	1	ecollection	ecollection	NOUN
bam-7218	65	2	2017	2017	NUM
bam-7218	65	3	jun	jun	PROPN
bam-7218	65	4	24	24	NUM
bam-7218	65	5	.	.	PUNCT
bam-7218	66	1	7	7	X
bam-7218	66	2	.	.	NUM
bam-7218	66	3	editors	editor	NOUN
bam-7218	66	4	.	.	PUNCT
bam-7218	67	1	muscle	muscle	NOUN
bam-7218	67	2	decline	decline	VERB
bam-7218	67	3	in	in	ADP
bam-7218	67	4	aging	age	VERB
bam-7218	67	5	and	and	CCONJ
bam-7218	67	6	neuromuscular	neuromuscular	ADJ
bam-7218	67	7	disorders	disorder	NOUN
bam-7218	67	8	mechanisms	mechanism	NOUN
bam-7218	67	9	and	and	CCONJ
bam-7218	67	10	countermeasures	countermeasure	NOUN
bam-7218	67	11	:	:	PUNCT
bam-7218	67	12	terme	terme	NOUN
bam-7218	67	13	euganee	euganee	NOUN
bam-7218	67	14	,	,	PUNCT
bam-7218	67	15	padova	padova	PROPN
bam-7218	67	16	(	(	PUNCT
bam-7218	67	17	italy	italy	PROPN
bam-7218	67	18	)	)	PUNCT
bam-7218	67	19	,	,	PUNCT
bam-7218	67	20	april	april	PROPN
bam-7218	67	21	13	13	NUM
bam-7218	67	22	-	-	SYM
bam-7218	67	23	16	16	NUM
bam-7218	67	24	,	,	PUNCT
bam-7218	67	25	2016	2016	NUM
bam-7218	67	26	.	.	PUNCT
bam-7218	68	1	eur	eur	PROPN
bam-7218	68	2	j	j	PROPN
bam-7218	68	3	transl	transl	PROPN
bam-7218	68	4	myol	myol	ADV
bam-7218	68	5	2016;26:5904	2016;26:5904	NUM
bam-7218	68	6	.	.	PUNCT
bam-7218	69	1	doi	doi	NOUN
bam-7218	69	2	:	:	PUNCT
bam-7218	69	3	10.4081	10.4081	NUM
bam-7218	69	4	/	/	SYM
bam-7218	69	5	ejtm.2016.5904	ejtm.2016.5904	PROPN
bam-7218	69	6	.	.	PUNCT
bam-7218	70	1	ecollection	ecollection	NOUN
bam-7218	70	2	2016	2016	NUM
bam-7218	70	3	feb	feb	NOUN
bam-7218	70	4	23	23	NUM
bam-7218	70	5	.	.	PUNCT
bam-7218	70	6	8	8	NUM
bam-7218	70	7	.	.	PUNCT
bam-7218	71	1	editors	editor	NOUN
bam-7218	71	2	.	.	PUNCT
bam-7218	72	1	functional	functional	ADJ
bam-7218	72	2	rejuvenation	rejuvenation	NOUN
bam-7218	72	3	in	in	ADP
bam-7218	72	4	aging	age	VERB
bam-7218	72	5	and	and	CCONJ
bam-7218	72	6	neuromuscular	neuromuscular	ADJ
bam-7218	72	7	disorders	disorder	NOUN
bam-7218	72	8	.	.	PUNCT
bam-7218	73	1	eur	eur	PROPN
bam-7218	73	2	j	j	PROPN
bam-7218	73	3	transl	transl	PROPN
bam-7218	73	4	myol	myol	NOUN
bam-7218	73	5	2015;25:269	2015;25:269	NOUN
bam-7218	73	6	-	-	SYM
bam-7218	73	7	75	75	NUM
bam-7218	73	8	.	.	PUNCT
bam-7218	74	1	doi	doi	NOUN
bam-7218	74	2	:	:	PUNCT
bam-7218	74	3	10.4081	10.4081	NUM
bam-7218	74	4	/	/	SYM
bam-7218	74	5	ejtm.2015.5607	ejtm.2015.5607	NOUN
bam-7218	74	6	ecollection	ecollection	NOUN
bam-7218	74	7	2015	2015	NUM
bam-7218	74	8	aug	aug	PROPN
bam-7218	74	9	24	24	NUM
bam-7218	74	10	.	.	NOUN
bam-7218	75	1	9	9	NUM
bam-7218	75	2	.	.	PUNCT
bam-7218	75	3	editors	editor	NOUN
bam-7218	75	4	.	.	PUNCT
bam-7218	76	1	2015spring	2015spre	VERB
bam-7218	76	2	paduamuscledays	paduamuscleday	NOUN
bam-7218	76	3	,	,	PUNCT
bam-7218	76	4	march	march	PROPN
bam-7218	76	5	1214	1214	NUM
bam-7218	76	6	,	,	PUNCT
bam-7218	76	7	2015	2015	NUM
bam-7218	76	8	terme	terme	NOUN
bam-7218	76	9	euganee	euganee	NOUN
bam-7218	76	10	(	(	PUNCT
bam-7218	76	11	padova	padova	PROPN
bam-7218	76	12	)	)	PUNCT
bam-7218	76	13	,	,	PUNCT
bam-7218	76	14	italy	italy	PROPN
bam-7218	76	15	abstracts	abstract	VERB
bam-7218	76	16	eur	eur	PROPN
bam-7218	76	17	j	j	PROPN
bam-7218	76	18	transl	transl	PROPN
bam-7218	76	19	myol	myol	NOUN
bam-7218	76	20	2015;25:145	2015;25:145	PROPN
bam-7218	76	21	-	-	SYM
bam-7218	76	22	82	82	NUM
bam-7218	76	23	.	.	NOUN
bam-7218	76	24	10	10	NUM
bam-7218	76	25	.	.	PUNCT
bam-7218	76	26	power	power	PROPN
bam-7218	76	27	ga	ga	PROPN
bam-7218	76	28	,	,	PUNCT
bam-7218	76	29	dalton	dalton	PROPN
bam-7218	76	30	bh	bh	PROPN
bam-7218	76	31	,	,	PUNCT
bam-7218	76	32	gilmore	gilmore	PROPN
bam-7218	76	33	kj	kj	PROPN
bam-7218	76	34	,	,	PUNCT
bam-7218	76	35	et	et	PROPN
bam-7218	76	36	al	al	PROPN
bam-7218	76	37	.	.	PUNCT
bam-7218	77	1	maintaining	maintain	VERB
bam-7218	77	2	motor	motor	NOUN
bam-7218	77	3	units	unit	NOUN
bam-7218	77	4	into	into	ADP
bam-7218	77	5	old	old	ADJ
bam-7218	77	6	age	age	NOUN
bam-7218	77	7	:	:	PUNCT
bam-7218	77	8	running	run	VERB
bam-7218	77	9	the	the	DET
bam-7218	77	10	final	final	ADJ
bam-7218	77	11	common	common	ADJ
bam-7218	77	12	pathway	pathway	NOUN
bam-7218	77	13	.	.	PUNCT
bam-7218	78	1	eur	eur	PROPN
bam-7218	78	2	j	j	PROPN
bam-7218	78	3	transl	transl	PROPN
bam-7218	78	4	myol	myol	PROPN
bam-7218	79	1	2017;27:6597	2017;27:6597	NUM
bam-7218	79	2	.	.	PUNCT
bam-7218	79	3	doi	doi	NOUN
bam-7218	79	4	:	:	PUNCT
bam-7218	79	5	10.4081	10.4081	NUM
bam-7218	79	6	/	/	SYM
bam-7218	79	7	ejtm.2017.6597	ejtm.2017.6597	PROPN
bam-7218	79	8	.	.	PUNCT
bam-7218	80	1	ecollection	ecollection	NOUN
bam-7218	80	2	2017	2017	NUM
bam-7218	80	3	feb	feb	NOUN
bam-7218	80	4	24	24	NUM
bam-7218	80	5	.	.	PUNCT
bam-7218	80	6	11	11	NUM
bam-7218	80	7	.	.	PUNCT
bam-7218	81	1	coletti	coletti	PROPN
bam-7218	81	2	d	d	PROPN
bam-7218	81	3	,	,	PUNCT
bam-7218	81	4	adamo	adamo	PROPN
bam-7218	81	5	s	s	PROPN
bam-7218	81	6	,	,	PUNCT
bam-7218	81	7	moresi	moresi	PROPN
bam-7218	81	8	v.	v.	INTJ
bam-7218	81	9	of	of	ADP
bam-7218	81	10	faeces	faece	NOUN
bam-7218	81	11	and	and	CCONJ
bam-7218	81	12	sweat	sweat	NOUN
bam-7218	81	13	.	.	PUNCT
bam-7218	82	1	how	how	SCONJ
bam-7218	82	2	much	much	ADJ
bam-7218	82	3	a	a	DET
bam-7218	82	4	mouse	mouse	NOUN
bam-7218	82	5	is	be	AUX
bam-7218	82	6	willing	willing	ADJ
bam-7218	82	7	to	to	PART
bam-7218	82	8	run	run	VERB
bam-7218	82	9	:	:	PUNCT
bam-7218	82	10	having	have	VERB
bam-7218	82	11	a	a	DET
bam-7218	82	12	hard	hard	ADJ
bam-7218	82	13	time	time	NOUN
bam-7218	82	14	measuring	measure	VERB
bam-7218	82	15	spontaneous	spontaneous	ADJ
bam-7218	82	16	physical	physical	ADJ
bam-7218	82	17	activity	activity	NOUN
bam-7218	82	18	in	in	ADP
bam-7218	82	19	different	different	ADJ
bam-7218	82	20	mouse	mouse	NOUN
bam-7218	82	21	sub	sub	NOUN
bam-7218	82	22	-	-	NOUN
bam-7218	82	23	strains	strain	NOUN
bam-7218	82	24	.	.	PUNCT
bam-7218	83	1	eur	eur	PROPN
bam-7218	83	2	j	j	PROPN
bam-7218	83	3	transl	transl	PROPN
bam-7218	83	4	myol	myol	PROPN
bam-7218	83	5	2017;27:6483	2017;27:6483	NUM
bam-7218	83	6	.	.	PUNCT
bam-7218	83	7	doi	doi	NOUN
bam-7218	83	8	:	:	PUNCT
bam-7218	83	9	10.4081	10.4081	NUM
bam-7218	83	10	/	/	SYM
bam-7218	83	11	ejtm.2017.6483	ejtm.2017.6483	PROPN
bam-7218	83	12	.	.	PUNCT
bam-7218	84	1	ecollection	ecollection	NOUN
bam-7218	84	2	2017	2017	NUM
bam-7218	84	3	feb	feb	NOUN
bam-7218	84	4	24	24	NUM
bam-7218	84	5	.	.	PUNCT
bam-7218	84	6	12	12	NUM
bam-7218	84	7	.	.	PUNCT
bam-7218	85	1	pigna	pigna	PROPN
bam-7218	85	2	e	e	PROPN
bam-7218	85	3	,	,	PUNCT
bam-7218	85	4	greco	greco	PROPN
bam-7218	85	5	e	e	PROPN
bam-7218	85	6	,	,	PUNCT
bam-7218	85	7	morozzi	morozzi	VERB
bam-7218	85	8	g	g	PROPN
bam-7218	85	9	,	,	PUNCT
bam-7218	85	10	et	et	PROPN
bam-7218	85	11	al	al	PROPN
bam-7218	85	12	.	.	PUNCT
bam-7218	85	13	denervation	denervation	NOUN
bam-7218	85	14	does	do	AUX
bam-7218	85	15	not	not	PART
bam-7218	85	16	induce	induce	VERB
bam-7218	85	17	muscle	muscle	NOUN
bam-7218	85	18	atrophy	atrophy	NOUN
bam-7218	85	19	through	through	ADP
bam-7218	85	20	oxidative	oxidative	ADJ
bam-7218	85	21	stress	stress	NOUN
bam-7218	85	22	.	.	PUNCT
bam-7218	86	1	eur	eur	PROPN
bam-7218	86	2	j	j	PROPN
bam-7218	86	3	transl	transl	PROPN
bam-7218	86	4	myol	myol	PROPN
bam-7218	86	5	2017;27:6406	2017;27:6406	X
bam-7218	86	6	.	.	PUNCT
bam-7218	86	7	doi	doi	NOUN
bam-7218	86	8	:	:	PUNCT
bam-7218	86	9	10.4081	10.4081	NUM
bam-7218	86	10	/	/	SYM
bam-7218	86	11	ejtm.2017.6406	ejtm.2017.6406	NOUN
bam-7218	86	12	.	.	PUNCT
bam-7218	87	1	ecollection	ecollection	NOUN
bam-7218	87	2	2017	2017	NUM
bam-7218	87	3	feb	feb	NOUN
bam-7218	87	4	24	24	NUM
bam-7218	87	5	.	.	PROPN
bam-7218	87	6	13	13	NUM
bam-7218	87	7	.	.	PUNCT
bam-7218	88	1	coste	coste	NOUN
bam-7218	88	2	ca	ca	PROPN
bam-7218	88	3	,	,	PUNCT
bam-7218	88	4	mayr	mayr	PROPN
bam-7218	88	5	w	w	PROPN
bam-7218	88	6	,	,	PUNCT
bam-7218	88	7	bijak	bijak	PROPN
bam-7218	88	8	m	m	PROPN
bam-7218	88	9	,	,	PUNCT
bam-7218	88	10	et	et	PROPN
bam-7218	88	11	al	al	PROPN
bam-7218	88	12	.	.	PROPN
bam-7218	88	13	fes	fes	PROPN
bam-7218	88	14	in	in	ADP
bam-7218	88	15	europe	europe	PROPN
bam-7218	88	16	and	and	CCONJ
bam-7218	88	17	beyond	beyond	ADP
bam-7218	88	18	:	:	PUNCT
bam-7218	88	19	current	current	ADJ
bam-7218	88	20	translational	translational	ADJ
bam-7218	88	21	research	research	NOUN
bam-7218	88	22	.	.	PUNCT
bam-7218	89	1	eur	eur	PROPN
bam-7218	89	2	j	j	PROPN
bam-7218	89	3	transl	transl	PROPN
bam-7218	89	4	myol	myol	NOUN
bam-7218	89	5	.	.	PUNCT
bam-7218	90	1	2016;26:6369	2016;26:6369	X
bam-7218	90	2	.	.	PUNCT
bam-7218	90	3	doi	doi	NOUN
bam-7218	90	4	:	:	PUNCT
bam-7218	90	5	10.4081	10.4081	NUM
bam-7218	90	6	/	/	SYM
bam-7218	90	7	ejtm.2016.6369	ejtm.2016.6369	PROPN
bam-7218	90	8	.	.	PUNCT
bam-7218	91	1	ecollection	ecollection	NOUN
bam-7218	91	2	2016	2016	NUM
bam-7218	91	3	sep	sep	PROPN
bam-7218	91	4	15	15	NUM
bam-7218	91	5	.	.	PUNCT
bam-7218	91	6	14	14	NUM
bam-7218	91	7	.	.	PUNCT
bam-7218	92	1	scicchitano	scicchitano	PROPN
bam-7218	92	2	bm	bm	PROPN
bam-7218	92	3	,	,	PUNCT
bam-7218	92	4	sica	sica	PROPN
bam-7218	92	5	g	g	PROPN
bam-7218	92	6	,	,	PUNCT
bam-7218	92	7	musarò	musarò	VERB
bam-7218	92	8	a.stem	a.stem	NOUN
bam-7218	92	9	cells	cell	NOUN
bam-7218	92	10	and	and	CCONJ
bam-7218	92	11	tissue	tissue	NOUN
bam-7218	92	12	niche	niche	NOUN
bam-7218	92	13	:	:	PUNCT
bam-7218	92	14	two	two	NUM
bam-7218	92	15	faces	face	NOUN
bam-7218	92	16	of	of	ADP
bam-7218	92	17	the	the	DET
bam-7218	92	18	same	same	ADJ
bam-7218	92	19	coin	coin	NOUN
bam-7218	92	20	of	of	ADP
bam-7218	92	21	muscle	muscle	NOUN
bam-7218	92	22	regeneration	regeneration	NOUN
bam-7218	92	23	.	.	PUNCT
bam-7218	93	1	eur	eur	PROPN
bam-7218	93	2	j	j	PROPN
bam-7218	93	3	transl	transl	PROPN
bam-7218	93	4	myol	myol	NOUN
bam-7218	93	5	201;26:6125	201;26:6125	NUM
bam-7218	93	6	.	.	PUNCT
bam-7218	93	7	doi	doi	NOUN
bam-7218	93	8	:	:	PUNCT
bam-7218	93	9	10.4081	10.4081	NUM
bam-7218	93	10	/	/	SYM
bam-7218	93	11	ejtm.2016.6125	ejtm.2016.6125	NOUN
bam-7218	93	12	.	.	PUNCT
bam-7218	94	1	ecollection	ecollection	NOUN
bam-7218	94	2	2016	2016	NUM
bam-7218	94	3	sep	sep	PROPN
bam-7218	94	4	15	15	NUM
bam-7218	94	5	.	.	PUNCT
bam-7218	94	6	15	15	NUM
bam-7218	94	7	.	.	PUNCT
bam-7218	94	8	lavorato	lavorato	PROPN
bam-7218	94	9	m	m	PROPN
bam-7218	94	10	,	,	PUNCT
bam-7218	94	11	gupta	gupta	PROPN
bam-7218	94	12	pk	pk	PROPN
bam-7218	94	13	,	,	PUNCT
bam-7218	94	14	hopkins	hopkins	PROPN
bam-7218	94	15	pm	pm	PROPN
bam-7218	94	16	,	,	PUNCT
bam-7218	94	17	franziniarmstrong	franziniarmstrong	ADJ
bam-7218	94	18	c.	c.	PROPN
bam-7218	94	19	skeletal	skeletal	ADJ
bam-7218	94	20	muscle	muscle	NOUN
bam-7218	94	21	microalterations	microalteration	NOUN
bam-7218	94	22	in	in	ADP
bam-7218	94	23	patients	patient	NOUN
bam-7218	94	24	carrying	carry	VERB
bam-7218	94	25	malignant	malignant	ADJ
bam-7218	94	26	hyperthermia	hyperthermia	NOUN
bam-7218	94	27	-	-	PUNCT
bam-7218	94	28	related	relate	VERB
bam-7218	94	29	mutations	mutation	NOUN
bam-7218	94	30	of	of	ADP
bam-7218	94	31	the	the	DET
bam-7218	94	32	e	e	PROPN
bam-7218	94	33	-	-	NOUN
bam-7218	94	34	c	c	ADJ
bam-7218	94	35	coupling	couple	VERB
bam-7218	94	36	machinery	machinery	NOUN
bam-7218	94	37	.	.	PUNCT
bam-7218	95	1	eur	eur	PROPN
bam-7218	95	2	j	j	PROPN
bam-7218	95	3	transl	transl	PROPN
bam-7218	95	4	myol	myol	PROPN
bam-7218	95	5	2016;26:6105	2016;26:6105	NUM
bam-7218	95	6	.	.	PUNCT
bam-7218	95	7	doi	doi	NOUN
bam-7218	95	8	:	:	PUNCT
bam-7218	95	9	10.4081	10.4081	NUM
bam-7218	95	10	/	/	SYM
bam-7218	95	11	ejtm	ejtm	NOUN
bam-7218	95	12	.	.	PUNCT
bam-7218	96	1	2016.6105	2016.6105	NUM
bam-7218	96	2	.	.	PUNCT
bam-7218	96	3	ecollection	ecollection	NOUN
bam-7218	96	4	2016	2016	NUM
bam-7218	96	5	sep	sep	PROPN
bam-7218	96	6	15	15	NUM
bam-7218	96	7	.	.	PUNCT
bam-7218	97	1	16	16	NUM
bam-7218	97	2	.	.	PUNCT
bam-7218	98	1	carotenuto	carotenuto	PROPN
bam-7218	98	2	f	f	PROPN
bam-7218	98	3	,	,	PUNCT
bam-7218	98	4	coletti	coletti	PROPN
bam-7218	98	5	d	d	PROPN
bam-7218	98	6	,	,	PUNCT
bam-7218	98	7	di	di	NOUN
bam-7218	98	8	nardo	nardo	PROPN
bam-7218	98	9	p	p	X
bam-7218	98	10	,	,	PUNCT
bam-7218	98	11	teodori	teodori	ADV
bam-7218	98	12	.	.	PUNCT
bam-7218	99	1	lαlinolenic	lαlinolenic	ADJ
bam-7218	99	2	acid	acid	NOUN
bam-7218	99	3	reduces	reduce	VERB
bam-7218	99	4	tnf	tnf	NOUN
bam-7218	99	5	-	-	PUNCT
bam-7218	99	6	induced	induce	VERB
bam-7218	99	7	apoptosis	apoptosis	NOUN
bam-7218	99	8	in	in	ADP
bam-7218	99	9	c2c12	c2c12	PROPN
bam-7218	99	10	myoblasts	myoblast	NOUN
bam-7218	99	11	by	by	ADP
bam-7218	99	12	regulating	regulate	VERB
bam-7218	99	13	expression	expression	NOUN
bam-7218	99	14	of	of	ADP
bam-7218	99	15	apoptotic	apoptotic	ADJ
bam-7218	99	16	proteins	protein	NOUN
bam-7218	99	17	.	.	PUNCT
bam-7218	100	1	eur	eur	PROPN
bam-7218	100	2	j	j	PROPN
bam-7218	100	3	transl	transl	PROPN
bam-7218	100	4	myol	myol	ADV
bam-7218	100	5	2016;26:6033	2016;26:6033	PROPN
bam-7218	100	6	.	.	PUNCT
bam-7218	100	7	doi	doi	NOUN
bam-7218	100	8	:	:	PUNCT
bam-7218	100	9	10.4081	10.4081	NUM
bam-7218	100	10	/	/	SYM
bam-7218	100	11	ejtm	ejtm	NOUN
bam-7218	100	12	.	.	PUNCT
bam-7218	101	1	2016.6033	2016.6033	NUM
bam-7218	101	2	.	.	PUNCT
bam-7218	102	1	ecollection	ecollection	NOUN
bam-7218	102	2	2016	2016	NUM
bam-7218	102	3	sep	sep	PROPN
bam-7218	102	4	15	15	NUM
bam-7218	102	5	.	.	PUNCT
bam-7218	102	6	17	17	NUM
bam-7218	102	7	.	.	PUNCT
bam-7218	103	1	mosole	mosole	NOUN
bam-7218	103	2	s	s	PROPN
bam-7218	103	3	,	,	PUNCT
bam-7218	103	4	carraro	carraro	NOUN
bam-7218	103	5	u	u	PROPN
bam-7218	103	6	,	,	PUNCT
bam-7218	103	7	kern	kern	PROPN
bam-7218	103	8	h	h	PROPN
bam-7218	103	9	,	,	PUNCT
bam-7218	103	10	et	et	PROPN
bam-7218	103	11	al	al	PROPN
bam-7218	103	12	.	.	PUNCT
bam-7218	103	13	use	use	VERB
bam-7218	103	14	it	it	PRON
bam-7218	103	15	or	or	CCONJ
bam-7218	103	16	lose	lose	VERB
bam-7218	103	17	it	it	PRON
bam-7218	103	18	:	:	PUNCT
bam-7218	103	19	tonic	tonic	NOUN
bam-7218	103	20	activity	activity	NOUN
bam-7218	103	21	of	of	ADP
bam-7218	103	22	slow	slow	ADJ
bam-7218	103	23	motoneurons	motoneuron	NOUN
bam-7218	103	24	promotes	promote	VERB
bam-7218	103	25	their	their	PRON
bam-7218	103	26	survival	survival	NOUN
bam-7218	103	27	and	and	CCONJ
bam-7218	103	28	preferentially	preferentially	ADV
bam-7218	103	29	increases	increase	VERB
bam-7218	103	30	slow	slow	ADJ
bam-7218	103	31	fiber	fiber	NOUN
bam-7218	103	32	-	-	PUNCT
bam-7218	103	33	type	type	NOUN
bam-7218	103	34	groupings	grouping	NOUN
bam-7218	103	35	in	in	ADP
bam-7218	103	36	muscles	muscle	NOUN
bam-7218	103	37	of	of	ADP
bam-7218	103	38	old	old	ADJ
bam-7218	103	39	lifelong	lifelong	ADJ
bam-7218	103	40	recreational	recreational	ADJ
bam-7218	103	41	sportsmen	sportsman	NOUN
bam-7218	103	42	.	.	PUNCT
bam-7218	104	1	eur	eur	PROPN
bam-7218	104	2	j	j	PROPN
bam-7218	104	3	transl	transl	PROPN
bam-7218	104	4	myol	myol	ADV
bam-7218	104	5	2016;26:5972	2016;26:5972	NUM
bam-7218	104	6	.	.	PUNCT
bam-7218	105	1	doi	doi	NOUN
bam-7218	105	2	:	:	PUNCT
bam-7218	105	3	10.4081/	10.4081/	PROPN
bam-7218	105	4	ejtm.2016.5972	ejtm.2016.5972	PROPN
bam-7218	105	5	.	.	PUNCT
bam-7218	106	1	ecollection	ecollection	NOUN
bam-7218	106	2	2016	2016	NUM
bam-7218	106	3	sep	sep	PROPN
bam-7218	106	4	15	15	NUM
bam-7218	106	5	.	.	PUNCT
bam-7218	106	6	18	18	NUM
bam-7218	106	7	.	.	PUNCT
bam-7218	106	8	edmunds	edmund	VERB
bam-7218	106	9	kj	kj	PROPN
bam-7218	106	10	,	,	PUNCT
bam-7218	106	11	gíslason	gíslason	PROPN
bam-7218	106	12	mk	mk	PROPN
bam-7218	106	13	,	,	PUNCT
bam-7218	106	14	arnadottir	arnadottir	ADV
bam-7218	106	15	i	i	PROPN
bam-7218	106	16	d	d	PROPN
bam-7218	106	17	,	,	PUNCT
bam-7218	106	18	et	et	PROPN
bam-7218	106	19	al	al	PROPN
bam-7218	106	20	.	.	PROPN
bam-7218	107	1	quantitative	quantitative	PROPN
bam-7218	107	2	computed	compute	VERB
bam-7218	107	3	tomography	tomography	NOUN
bam-7218	107	4	and	and	CCONJ
bam-7218	107	5	image	image	NOUN
bam-7218	107	6	analysis	analysis	NOUN
bam-7218	107	7	for	for	ADP
bam-7218	107	8	advanced	advanced	ADJ
bam-7218	107	9	muscle	muscle	NOUN
bam-7218	107	10	assessment	assessment	NOUN
bam-7218	107	11	.	.	PUNCT
bam-7218	108	1	eur	eur	PROPN
bam-7218	108	2	j	j	PROPN
bam-7218	108	3	transl	transl	PROPN
bam-7218	108	4	myol	myol	NOUN
bam-7218	108	5	2016;26:6015	2016;26:6015	PROPN
bam-7218	108	6	.	.	PUNCT
bam-7218	109	1	doi	doi	NOUN
bam-7218	109	2	:	:	PUNCT
bam-7218	109	3	10.4081	10.4081	NUM
bam-7218	109	4	/	/	SYM
bam-7218	109	5	ejtm	ejtm	NOUN
bam-7218	109	6	.	.	PUNCT
bam-7218	110	1	2016.6015	2016.6015	X
bam-7218	110	2	.	.	PUNCT
bam-7218	111	1	ecollection	ecollection	NOUN
bam-7218	111	2	2016	2016	NUM
bam-7218	111	3	jun	jun	PROPN
bam-7218	111	4	13	13	NUM
bam-7218	111	5	.	.	X
bam-7218	111	6	19	19	NUM
bam-7218	111	7	.	.	PUNCT
bam-7218	112	1	coletti	coletti	PROPN
bam-7218	112	2	d	d	PROPN
bam-7218	112	3	,	,	PUNCT
bam-7218	112	4	daou	daou	NOUN
bam-7218	112	5	n	n	PRON
bam-7218	112	6	,	,	PUNCT
bam-7218	112	7	hassani	hassani	PROPN
bam-7218	112	8	m	m	PROPN
bam-7218	112	9	,	,	PUNCT
bam-7218	112	10	et	et	PROPN
bam-7218	112	11	al	al	PROPN
bam-7218	112	12	.	.	PROPN
bam-7218	113	1	serum	serum	PROPN
bam-7218	113	2	response	response	NOUN
bam-7218	113	3	factor	factor	NOUN
bam-7218	113	4	in	in	ADP
bam-7218	113	5	muscle	muscle	NOUN
bam-7218	113	6	tissues	tissue	NOUN
bam-7218	113	7	:	:	PUNCT
bam-7218	113	8	from	from	ADP
bam-7218	113	9	development	development	NOUN
bam-7218	113	10	to	to	ADP
bam-7218	113	11	ageing	age	VERB
bam-7218	113	12	.	.	PUNCT
bam-7218	114	1	eur	eur	PROPN
bam-7218	114	2	j	j	PROPN
bam-7218	114	3	transl	transl	PROPN
bam-7218	114	4	myol	myol	PROPN
bam-7218	114	5	2016;26:6008	2016;26:6008	PROPN
bam-7218	114	6	.	.	PUNCT
bam-7218	114	7	doi	doi	NOUN
bam-7218	114	8	:	:	PUNCT
bam-7218	114	9	10.4081	10.4081	NUM
bam-7218	114	10	/	/	SYM
bam-7218	114	11	ejtm.2016	ejtm.2016	PROPN
bam-7218	114	12	.	.	PUNCT
bam-7218	114	13	6008	6008	NUM
bam-7218	114	14	.	.	PUNCT
bam-7218	115	1	ecollection	ecollection	NOUN
bam-7218	115	2	2016	2016	NUM
bam-7218	115	3	jun	jun	PROPN
bam-7218	115	4	13	13	NUM
bam-7218	115	5	.	.	PROPN
bam-7218	115	6	20	20	NUM
bam-7218	115	7	.	.	PUNCT
bam-7218	116	1	hiroux	hiroux	PROPN
bam-7218	116	2	c	c	NOUN
bam-7218	116	3	,	,	PUNCT
bam-7218	116	4	vandoorne	vandoorne	VERB
bam-7218	116	5	t	t	PROPN
bam-7218	116	6	,	,	PUNCT
bam-7218	116	7	koppo	koppo	PROPN
bam-7218	116	8	et	et	PROPN
bam-7218	116	9	al	al	PROPN
bam-7218	116	10	.	.	PROPN
bam-7218	117	1	physical	physical	ADJ
bam-7218	117	2	activity	activity	NOUN
bam-7218	117	3	counteracts	counteract	VERB
bam-7218	117	4	tumor	tumor	NOUN
bam-7218	117	5	cell	cell	NOUN
bam-7218	117	6	growth	growth	NOUN
bam-7218	117	7	in	in	ADP
bam-7218	117	8	colon	colon	NOUN
bam-7218	117	9	carcinoma	carcinoma	NOUN
bam-7218	117	10	c26	c26	NOUN
bam-7218	117	11	-	-	PUNCT
bam-7218	117	12	injected	inject	VERB
bam-7218	117	13	muscles	muscle	NOUN
bam-7218	117	14	:	:	PUNCT
bam-7218	117	15	an	an	DET
bam-7218	117	16	interim	interim	ADJ
bam-7218	117	17	report	report	NOUN
bam-7218	117	18	.	.	PUNCT
bam-7218	118	1	eur	eur	PROPN
bam-7218	118	2	j	j	PROPN
bam-7218	118	3	transl	transl	PROPN
bam-7218	118	4	myol	myol	NOUN
bam-7218	118	5	2016;26:5958	2016;26:5958	NUM
bam-7218	118	6	.	.	PUNCT
bam-7218	118	7	doi	doi	NOUN
bam-7218	118	8	:	:	PUNCT
bam-7218	118	9	10.4081	10.4081	NUM
bam-7218	118	10	/	/	SYM
bam-7218	118	11	ejtm.2016.5958	ejtm.2016.5958	NOUN
bam-7218	118	12	.	.	PUNCT
bam-7218	119	1	ecollection	ecollection	NOUN
bam-7218	119	2	2016	2016	NUM
bam-7218	119	3	jun	jun	PROPN
bam-7218	119	4	13	13	NUM
bam-7218	119	5	.	.	PUNCT
bam-7218	119	6	21	21	NUM
bam-7218	119	7	.	.	PUNCT
bam-7218	120	1	tramonti	tramonti	PROPN
bam-7218	120	2	c	c	PROPN
bam-7218	120	3	,	,	PUNCT
bam-7218	120	4	rossi	rossi	PROPN
bam-7218	120	5	b	b	X
bam-7218	120	6	,	,	PUNCT
bam-7218	120	7	chisari	chisari	ADJ
bam-7218	120	8	c.	c.	PROPN
bam-7218	120	9	extensive	extensive	ADJ
bam-7218	120	10	functional	functional	ADJ
bam-7218	120	11	evaluations	evaluation	NOUN
bam-7218	120	12	to	to	PART
bam-7218	120	13	monitor	monitor	VERB
bam-7218	120	14	aerobic	aerobic	ADJ
bam-7218	120	15	training	training	NOUN
bam-7218	120	16	in	in	ADP
bam-7218	120	17	becker	becker	NOUN
bam-7218	120	18	muscular	muscular	ADJ
bam-7218	120	19	dystrophy	dystrophy	NOUN
bam-7218	120	20	:	:	PUNCT
bam-7218	120	21	a	a	DET
bam-7218	120	22	case	case	NOUN
bam-7218	120	23	report	report	NOUN
bam-7218	120	24	.	.	PUNCT
bam-7218	121	1	eur	eur	PROPN
bam-7218	121	2	j	j	PROPN
bam-7218	121	3	transl	transl	PROPN
bam-7218	121	4	myol	myol	ADV
bam-7218	121	5	2016;26:5873	2016;26:5873	NUM
bam-7218	121	6	.	.	PUNCT
bam-7218	121	7	doi	doi	NOUN
bam-7218	121	8	:	:	PUNCT
bam-7218	121	9	10.4081	10.4081	NUM
bam-7218	121	10	/	/	SYM
bam-7218	121	11	ejtm.2016.5873	ejtm.2016.5873	PROPN
bam-7218	121	12	.	.	PUNCT
bam-7218	122	1	ecollection	ecollection	NOUN
bam-7218	122	2	2016	2016	NUM
bam-7218	122	3	jun	jun	PROPN
bam-7218	122	4	13	13	NUM
bam-7218	122	5	.	.	PUNCT
bam-7218	122	6	22	22	NUM
bam-7218	122	7	.	.	PUNCT
bam-7218	123	1	riuzzi	riuzzi	NOUN
bam-7218	123	2	f	f	PROPN
bam-7218	123	3	,	,	PUNCT
bam-7218	123	4	beccafico	beccafico	PROPN
bam-7218	123	5	s	s	PART
bam-7218	123	6	,	,	PUNCT
bam-7218	123	7	sorci	sorci	VERB
bam-7218	123	8	g	g	PROPN
bam-7218	123	9	,	,	PUNCT
bam-7218	123	10	donato	donato	PROPN
bam-7218	123	11	r.	r.	PROPN
bam-7218	123	12	s100b	s100b	PROPN
bam-7218	123	13	protein	protein	NOUN
bam-7218	123	14	in	in	ADP
bam-7218	123	15	skeletal	skeletal	ADJ
bam-7218	123	16	muscle	muscle	NOUN
bam-7218	123	17	regeneration	regeneration	NOUN
bam-7218	123	18	:	:	PUNCT
bam-7218	123	19	regulation	regulation	NOUN
bam-7218	123	20	of	of	ADP
bam-7218	123	21	myoblast	myoblast	ADJ
bam-7218	123	22	and	and	CCONJ
bam-7218	123	23	macrophage	macrophage	ADJ
bam-7218	123	24	functions	function	NOUN
bam-7218	123	25	.	.	PUNCT
bam-7218	124	1	eur	eur	PROPN
bam-7218	124	2	j	j	PROPN
bam-7218	124	3	transl	transl	PROPN
bam-7218	124	4	myol	myol	NOUN
bam-7218	124	5	2016;26:5830	2016;26:5830	NUM
bam-7218	124	6	.	.	PUNCT
bam-7218	125	1	doi	doi	NOUN
bam-7218	125	2	:	:	PUNCT
bam-7218	125	3	10.4081	10.4081	NUM
bam-7218	125	4	/	/	SYM
bam-7218	125	5	ejtm.2016.5830	ejtm.2016.5830	NOUN
bam-7218	125	6	.	.	PUNCT
bam-7218	126	1	ecollection	ecollection	NOUN
bam-7218	126	2	2016	2016	NUM
bam-7218	126	3	feb	feb	NOUN
bam-7218	126	4	23	23	NUM
bam-7218	126	5	.	.	PUNCT
bam-7218	127	1	23	23	NUM
bam-7218	127	2	.	.	PUNCT
bam-7218	128	1	barber	barber	PROPN
bam-7218	128	2	l	l	PROPN
bam-7218	128	3	,	,	PUNCT
bam-7218	128	4	scicchitano	scicchitano	ADJ
bam-7218	128	5	bm	bm	PROPN
bam-7218	128	6	,	,	PUNCT
bam-7218	128	7	musaro	musaro	VERB
bam-7218	128	8	a.	a.	NOUN
bam-7218	128	9	molecular	molecular	ADJ
bam-7218	128	10	and	and	CCONJ
bam-7218	128	11	cellular	cellular	ADJ
bam-7218	128	12	mechanisms	mechanism	NOUN
bam-7218	128	13	of	of	ADP
bam-7218	128	14	muscle	muscle	NOUN
bam-7218	128	15	aging	aging	NOUN
bam-7218	128	16	and	and	CCONJ
bam-7218	128	17	sarcopenia	sarcopenia	NOUN
bam-7218	128	18	and	and	CCONJ
bam-7218	128	19	effects	effect	NOUN
bam-7218	128	20	of	of	ADP
bam-7218	128	21	electrical	electrical	ADJ
bam-7218	128	22	stimulation	stimulation	NOUN
bam-7218	128	23	in	in	ADP
bam-7218	128	24	seniors	senior	NOUN
bam-7218	128	25	.	.	PUNCT
bam-7218	129	1	eur	eur	PROPN
bam-7218	129	2	j	j	PROPN
bam-7218	129	3	transl	transl	PROPN
bam-7218	129	4	myol	myol	NOUN
bam-7218	129	5	2015;25:231	2015;25:231	PROPN
bam-7218	129	6	-	-	SYM
bam-7218	129	7	6	6	NUM
bam-7218	129	8	.	.	PUNCT
bam-7218	129	9	doi	doi	NOUN
bam-7218	129	10	:	:	PUNCT
bam-7218	129	11	10.4081	10.4081	NUM
bam-7218	129	12	/	/	SYM
bam-7218	129	13	ejtm.2015.5227	ejtm.2015.5227	NOUN
bam-7218	129	14	.	.	PUNCT
bam-7218	130	1	ecollection	ecollection	NOUN
bam-7218	130	2	2015	2015	NUM
bam-7218	130	3	aug	aug	PROPN
bam-7218	130	4	24	24	NUM
bam-7218	130	5	.	.	PUNCT
bam-7218	130	6	review	review	NOUN
bam-7218	130	7	.	.	PUNCT
bam-7218	131	1	24	24	NUM
bam-7218	131	2	.	.	PUNCT
bam-7218	131	3	gabrielli	gabrielli	PROPN
bam-7218	132	1	e	e	NOUN
bam-7218	132	2	,	,	PUNCT
bam-7218	132	3	fulle	fulle	NOUN
bam-7218	132	4	s	s	NOUN
bam-7218	132	5	,	,	PUNCT
bam-7218	132	6	fanò	fanò	NOUN
bam-7218	132	7	-	-	PUNCT
bam-7218	132	8	illic	illic	NOUN
bam-7218	132	9	g	g	NOUN
bam-7218	132	10	,	,	PUNCT
bam-7218	132	11	pietrangelo	pietrangelo	VERB
bam-7218	132	12	t.	t.	NOUN
bam-7218	132	13	analysis	analysis	NOUN
bam-7218	132	14	of	of	ADP
bam-7218	132	15	training	training	NOUN
bam-7218	132	16	load	load	NOUN
bam-7218	132	17	and	and	CCONJ
bam-7218	132	18	competition	competition	NOUN
bam-7218	132	19	during	during	ADP
bam-7218	132	20	the	the	DET
bam-7218	132	21	phd	phd	NOUN
bam-7218	132	22	course	course	NOUN
bam-7218	132	23	of	of	ADP
bam-7218	132	24	a	a	DET
bam-7218	132	25	3000	3000	NUM
bam-7218	132	26	-	-	PUNCT
bam-7218	132	27	m	m	NOUN
bam-7218	132	28	steeplechase	steeplechase	NOUN
bam-7218	132	29	female	female	ADJ
bam-7218	132	30	master	master	NOUN
bam-7218	132	31	athlete	athlete	NOUN
bam-7218	132	32	:	:	PUNCT
bam-7218	132	33	an	an	DET
bam-7218	132	34	autobiography	autobiography	NOUN
bam-7218	132	35	.	.	PUNCT
bam-7218	133	1	eur	eur	PROPN
bam-7218	133	2	j	j	PROPN
bam-7218	133	3	transl	transl	PROPN
bam-7218	133	4	myol	myol	NOUN
bam-7218	133	5	2015;25:5184	2015;25:5184	NUM
bam-7218	133	6	.	.	PUNCT
bam-7218	133	7	doi	doi	NOUN
bam-7218	133	8	:	:	PUNCT
bam-7218	133	9	10.4081	10.4081	NUM
bam-7218	133	10	/	/	SYM
bam-7218	133	11	ejtm.2015.5184	ejtm.2015.5184	X
bam-7218	133	12	.	.	PUNCT
bam-7218	134	1	ecollection	ecollection	NOUN
bam-7218	134	2	2015	2015	NUM
bam-7218	134	3	sep	sep	PROPN
bam-7218	134	4	11	11	NUM
bam-7218	134	5	.	.	PUNCT
bam-7218	134	6	25	25	NUM
bam-7218	134	7	.	.	PUNCT
bam-7218	135	1	gargiulo	gargiulo	NOUN
bam-7218	135	2	p	p	X
bam-7218	135	3	,	,	PUNCT
bam-7218	135	4	helgason	helgason	PROPN
bam-7218	135	5	t	t	PROPN
bam-7218	135	6	,	,	PUNCT
bam-7218	135	7	ramon	ramon	NOUN
bam-7218	135	8	c	c	NOUN
bam-7218	135	9	,	,	PUNCT
bam-7218	135	10	et	et	PROPN
bam-7218	135	11	al	al	PROPN
bam-7218	135	12	.	.	PROPN
bam-7218	136	1	ct	ct	PROPN
bam-7218	136	2	and	and	CCONJ
bam-7218	136	3	mri	mri	NOUN
bam-7218	136	4	assessment	assessment	NOUN
bam-7218	136	5	and	and	CCONJ
bam-7218	136	6	characterization	characterization	NOUN
bam-7218	136	7	using	use	VERB
bam-7218	136	8	segmentation	segmentation	NOUN
bam-7218	136	9	and	and	CCONJ
bam-7218	136	10	3d	3d	NUM
bam-7218	136	11	modeling	modeling	NOUN
bam-7218	136	12	techniques	technique	NOUN
bam-7218	136	13	:	:	PUNCT
bam-7218	136	14	applications	application	NOUN
bam-7218	136	15	to	to	ADP
bam-7218	136	16	muscle	muscle	NOUN
bam-7218	136	17	,	,	PUNCT
bam-7218	136	18	bone	bone	NOUN
bam-7218	136	19	and	and	CCONJ
bam-7218	136	20	brain	brain	NOUN
bam-7218	136	21	.	.	PUNCT
bam-7218	137	1	eur	eur	PROPN
bam-7218	137	2	j	j	PROPN
bam-7218	137	3	transl	transl	PROPN
bam-7218	137	4	myol	myol	NOUN
bam-7218	137	5	2014;24:3298	2014;24:3298	NUM
bam-7218	137	6	.	.	PUNCT
bam-7218	138	1	doi	doi	NOUN
bam-7218	138	2	:	:	PUNCT
bam-7218	138	3	10.4081	10.4081	NUM
bam-7218	138	4	/	/	SYM
bam-7218	138	5	ejtm	ejtm	NOUN
bam-7218	138	6	.	.	PUNCT
bam-7218	139	1	2014	2014	NUM
bam-7218	139	2	3298	3298	NUM
bam-7218	139	3	.	.	PUNCT
bam-7218	140	1	ecollection	ecollection	NOUN
bam-7218	140	2	2014	2014	NUM
bam-7218	140	3	mar	mar	PROPN
bam-7218	140	4	31	31	NUM
bam-7218	140	5	.	.	PUNCT
bam-7218	141	1	https://www.ncbi.nlm.nih.gov/pubmed/27054019	https://www.ncbi.nlm.nih.gov/pubmed/27054019	X
bam-7218	141	2	https://www.ncbi.nlm.nih.gov/pubmed/27054019	https://www.ncbi.nlm.nih.gov/pubmed/27054019	NUM
bam-7218	141	3	https://www.ncbi.nlm.nih.gov/pubmed/27054019	https://www.ncbi.nlm.nih.gov/pubmed/27054019	NUM
bam-7218	141	4	14	14	NUM
bam-7218	141	5	th	th	NUM
bam-7218	141	6	iiim	iiim	NOUN
bam-7218	141	7	meeting	meeting	NOUN
bam-7218	141	8	,	,	PUNCT
bam-7218	141	9	assisi	assisi	PROPN
bam-7218	141	10	,	,	PUNCT
bam-7218	141	11	italy	italy	PROPN
bam-7218	141	12	october	october	PROPN
bam-7218	141	13	12	12	NUM
bam-7218	141	14	-	-	SYM
bam-7218	141	15	15	15	NUM
bam-7218	141	16	2017	2017	NUM
bam-7218	141	17	eur	eur	PROPN
bam-7218	141	18	j	j	PROPN
bam-7218	141	19	transl	transl	PROPN
bam-7218	141	20	myol	myol	ADV
bam-7218	141	21	27	27	NUM
bam-7218	141	22	(	(	PUNCT
bam-7218	141	23	4	4	NUM
bam-7218	141	24	):	):	SYM
bam-7218	141	25	185	185	NUM
bam-7218	141	26	-	-	SYM
bam-7218	141	27	224	224	NUM
bam-7218	141	28	188	188	NUM
bam-7218	141	29	26	26	NUM
bam-7218	141	30	.	.	PUNCT
bam-7218	142	1	ortolan	ortolan	PROPN
bam-7218	142	2	p	p	PROPN
bam-7218	142	3	,	,	PUNCT
bam-7218	142	4	zanato	zanato	PROPN
bam-7218	142	5	r	r	PROPN
bam-7218	142	6	,	,	PUNCT
bam-7218	142	7	coran	coran	PROPN
bam-7218	142	8	a	a	PROPN
bam-7218	142	9	,	,	PUNCT
bam-7218	142	10	et	et	PROPN
bam-7218	142	11	al	al	PROPN
bam-7218	142	12	.	.	PROPN
bam-7218	142	13	role	role	NOUN
bam-7218	142	14	of	of	ADP
bam-7218	142	15	radiologic	radiologic	ADJ
bam-7218	142	16	imaging	imaging	NOUN
bam-7218	142	17	in	in	ADP
bam-7218	142	18	genetic	genetic	ADJ
bam-7218	142	19	and	and	CCONJ
bam-7218	142	20	acquired	acquire	VERB
bam-7218	142	21	neuromuscular	neuromuscular	ADJ
bam-7218	142	22	disorders	disorder	NOUN
bam-7218	142	23	.	.	PUNCT
bam-7218	143	1	eur	eur	PROPN
bam-7218	143	2	j	j	PROPN
bam-7218	143	3	transl	transl	PROPN
bam-7218	143	4	myol	myol	NOUN
bam-7218	143	5	2015;25:5014	2015;25:5014	NUM
bam-7218	143	6	.	.	PUNCT
bam-7218	144	1	doi	doi	NOUN
bam-7218	144	2	:	:	PUNCT
bam-7218	144	3	10.4081	10.4081	NUM
bam-7218	144	4	/	/	SYM
bam-7218	144	5	ejtm.2015.5014	ejtm.2015.5014	NOUN
bam-7218	144	6	.	.	PUNCT
bam-7218	145	1	ecollection	ecollection	NOUN
bam-7218	145	2	2015	2015	NUM
bam-7218	145	3	mar	mar	PROPN
bam-7218	145	4	11	11	NUM
bam-7218	145	5	.	.	PUNCT
bam-7218	146	1	review	review	NOUN
bam-7218	146	2	.	.	PUNCT
bam-7218	147	1	27	27	NUM
bam-7218	147	2	.	.	PUNCT
bam-7218	148	1	ravara	ravara	PROPN
bam-7218	148	2	b	b	PROPN
bam-7218	148	3	,	,	PUNCT
bam-7218	148	4	gobbo	gobbo	PROPN
bam-7218	148	5	v	v	PROPN
bam-7218	148	6	,	,	PUNCT
bam-7218	148	7	carraro	carraro	NOUN
bam-7218	148	8	u	u	NOUN
bam-7218	148	9	,	,	PUNCT
bam-7218	148	10	et	et	PROPN
bam-7218	148	11	al	al	PROPN
bam-7218	148	12	.	.	PUNCT
bam-7218	149	1	functional	functional	ADJ
bam-7218	149	2	electrical	electrical	ADJ
bam-7218	149	3	stimulation	stimulation	NOUN
bam-7218	149	4	as	as	ADP
bam-7218	149	5	a	a	DET
bam-7218	149	6	safe	safe	ADJ
bam-7218	149	7	and	and	CCONJ
bam-7218	149	8	effective	effective	ADJ
bam-7218	149	9	treatment	treatment	NOUN
bam-7218	149	10	for	for	ADP
bam-7218	149	11	equine	equine	NOUN
bam-7218	149	12	epaxial	epaxial	ADJ
bam-7218	149	13	muscle	muscle	NOUN
bam-7218	149	14	spasms	spasm	NOUN
bam-7218	149	15	:	:	PUNCT
bam-7218	149	16	clinical	clinical	ADJ
bam-7218	149	17	evaluations	evaluation	NOUN
bam-7218	149	18	and	and	CCONJ
bam-7218	149	19	histochemical	histochemical	ADJ
bam-7218	149	20	morphometry	morphometry	NOUN
bam-7218	149	21	of	of	ADP
bam-7218	149	22	mitochondria	mitochondria	PROPN
bam-7218	149	23	in	in	ADP
bam-7218	149	24	muscle	muscle	NOUN
bam-7218	149	25	biopsies	biopsy	NOUN
bam-7218	149	26	.	.	PUNCT
bam-7218	150	1	eur	eur	PROPN
bam-7218	150	2	j	j	PROPN
bam-7218	150	3	transl	transl	PROPN
bam-7218	150	4	myol	myol	PROPN
bam-7218	150	5	201525:4910	201525:4910	PROPN
bam-7218	150	6	.	.	PUNCT
bam-7218	150	7	doi	doi	NOUN
bam-7218	150	8	:	:	PUNCT
bam-7218	150	9	10.4081	10.4081	NUM
bam-7218	150	10	/	/	SYM
bam-7218	150	11	ejtm.2015.4910	ejtm.2015.4910	NOUN
bam-7218	150	12	.	.	PUNCT
bam-7218	151	1	ecollection	ecollection	NOUN
bam-7218	151	2	2015	2015	NUM
bam-7218	151	3	mar	mar	PROPN
bam-7218	151	4	11	11	NUM
bam-7218	151	5	.	.	PUNCT
bam-7218	151	6	28	28	NUM
bam-7218	151	7	.	.	PUNCT
bam-7218	152	1	franzini	franzini	PROPN
bam-7218	152	2	-	-	PUNCT
bam-7218	152	3	armstrong	armstrong	PROPN
bam-7218	152	4	c.	c.	PROPN
bam-7218	152	5	electron	electron	PROPN
bam-7218	152	6	microscopy	microscopy	PROPN
bam-7218	152	7	:	:	PUNCT
bam-7218	152	8	from	from	ADP
bam-7218	152	9	2d	2d	NUM
bam-7218	152	10	to	to	ADP
bam-7218	152	11	3d	3d	NUM
bam-7218	152	12	images	image	NOUN
bam-7218	152	13	with	with	ADP
bam-7218	152	14	special	special	ADJ
bam-7218	152	15	reference	reference	NOUN
bam-7218	152	16	to	to	ADP
bam-7218	152	17	muscle	muscle	NOUN
bam-7218	152	18	.	.	PUNCT
bam-7218	153	1	eur	eur	PROPN
bam-7218	153	2	j	j	PROPN
bam-7218	153	3	transl	transl	PROPN
bam-7218	153	4	myol	myol	NOUN
bam-7218	153	5	2015;25:4836	2015;25:4836	NUM
bam-7218	153	6	.	.	PUNCT
bam-7218	154	1	doi	doi	NOUN
bam-7218	154	2	:	:	PUNCT
bam-7218	154	3	10.4081	10.4081	NUM
bam-7218	154	4	/	/	SYM
bam-7218	154	5	ejtm.2015.4836	ejtm.2015.4836	NOUN
bam-7218	154	6	.	.	PUNCT
bam-7218	155	1	ecollection	ecollection	NOUN
bam-7218	155	2	2015	2015	NUM
bam-7218	155	3	jan	jan	PROPN
bam-7218	155	4	7	7	NUM
bam-7218	155	5	.	.	PUNCT
bam-7218	155	6	review	review	NOUN
bam-7218	155	7	.	.	PUNCT
bam-7218	156	1	29	29	NUM
bam-7218	156	2	.	.	PUNCT
bam-7218	157	1	costa	costa	PROPN
bam-7218	157	2	a	a	PRON
bam-7218	157	3	,	,	PUNCT
bam-7218	157	4	rossi	rossi	ADJ
bam-7218	157	5	e	e	NOUN
bam-7218	157	6	,	,	PUNCT
bam-7218	157	7	scicchitano	scicchitano	ADJ
bam-7218	157	8	bm	bm	PROPN
bam-7218	157	9	,	,	PUNCT
bam-7218	157	10	et	et	PROPN
bam-7218	157	11	al	al	PROPN
bam-7218	157	12	.	.	PROPN
bam-7218	157	13	neurohypophyseal	neurohypophyseal	PROPN
bam-7218	157	14	hormones	hormone	NOUN
bam-7218	157	15	:	:	PUNCT
bam-7218	157	16	novel	novel	ADJ
bam-7218	157	17	actors	actor	NOUN
bam-7218	157	18	of	of	ADP
bam-7218	157	19	striated	striated	ADJ
bam-7218	157	20	muscle	muscle	NOUN
bam-7218	157	21	development	development	NOUN
bam-7218	157	22	and	and	CCONJ
bam-7218	157	23	homeostasis	homeostasis	NOUN
bam-7218	157	24	.	.	PUNCT
bam-7218	158	1	eur	eur	PROPN
bam-7218	158	2	j	j	PROPN
bam-7218	158	3	transl	transl	PROPN
bam-7218	158	4	myol	myol	NOUN
bam-7218	158	5	2014;24:3790	2014;24:3790	NUM
bam-7218	158	6	.	.	PUNCT
bam-7218	158	7	doi	doi	NOUN
bam-7218	158	8	:	:	PUNCT
bam-7218	158	9	10.4081	10.4081	NUM
bam-7218	158	10	/	/	SYM
bam-7218	158	11	ejtm.2014.3790	ejtm.2014.3790	NOUN
bam-7218	158	12	.	.	PUNCT
bam-7218	159	1	ecollection	ecollection	NOUN
bam-7218	159	2	2014	2014	NUM
bam-7218	159	3	sep	sep	PROPN
bam-7218	159	4	23	23	NUM
bam-7218	159	5	.	.	PUNCT
bam-7218	160	1	review	review	NOUN
bam-7218	160	2	.	.	PUNCT
bam-7218	161	1	30	30	NUM
bam-7218	161	2	.	.	PUNCT
bam-7218	162	1	veneziani	veneziani	PROPN
bam-7218	162	2	s	s	PART
bam-7218	162	3	,	,	PUNCT
bam-7218	162	4	doria	doria	PROPN
bam-7218	162	5	c	c	PROPN
bam-7218	162	6	,	,	PUNCT
bam-7218	162	7	falciati	falciati	PROPN
bam-7218	162	8	l	l	PROPN
bam-7218	162	9	,	,	PUNCT
bam-7218	162	10	castelli	castelli	PROPN
bam-7218	162	11	cc	cc	PROPN
bam-7218	162	12	,	,	PUNCT
bam-7218	162	13	illic	illic	PROPN
bam-7218	162	14	gf	gf	PROPN
bam-7218	162	15	.	.	PUNCT
bam-7218	162	16	return	return	VERB
bam-7218	162	17	to	to	ADP
bam-7218	162	18	competition	competition	NOUN
bam-7218	162	19	in	in	ADP
bam-7218	162	20	a	a	DET
bam-7218	162	21	chronic	chronic	ADJ
bam-7218	162	22	low	low	ADJ
bam-7218	162	23	back	back	NOUN
bam-7218	162	24	pain	pain	NOUN
bam-7218	162	25	runner	runner	NOUN
bam-7218	162	26	:	:	PUNCT
bam-7218	162	27	beyond	beyond	ADP
bam-7218	162	28	a	a	DET
bam-7218	162	29	therapeutic	therapeutic	ADJ
bam-7218	162	30	exercise	exercise	NOUN
bam-7218	162	31	approach	approach	NOUN
bam-7218	162	32	,	,	PUNCT
bam-7218	162	33	a	a	DET
bam-7218	162	34	case	case	NOUN
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bam-7218	162	36	.	.	PUNCT
bam-7218	163	1	eur	eur	PROPN
bam-7218	163	2	j	j	PROPN
bam-7218	163	3	transl	transl	PROPN
bam-7218	163	4	myol	myol	NOUN
bam-7218	163	5	2014;24:2221	2014;24:2221	PROPN
bam-7218	163	6	.	.	PUNCT
bam-7218	163	7	doi	doi	NOUN
bam-7218	163	8	:	:	PUNCT
bam-7218	163	9	10.4081	10.4081	NUM
bam-7218	163	10	/	/	SYM
bam-7218	163	11	ejtm.2014	ejtm.2014	PROPN
bam-7218	163	12	.	.	NOUN
bam-7218	163	13	2221	2221	NUM
bam-7218	163	14	.	.	PUNCT
bam-7218	164	1	ecollection	ecollection	NOUN
bam-7218	164	2	2014	2014	NUM
bam-7218	164	3	sep	sep	PROPN
bam-7218	164	4	23	23	NUM
bam-7218	164	5	.	.	PUNCT
bam-7218	165	1	abstracts	abstract	NOUN
bam-7218	165	2	of	of	ADP
bam-7218	165	3	the	the	DET
bam-7218	165	4	14	14	NUM
bam-7218	165	5	th	th	NUM
bam-7218	165	6	iim	iim	PROPN
bam-7218	165	7	meeting	meeting	NOUN
bam-7218	165	8	,	,	PUNCT
bam-7218	165	9	assisi	assisi	PROPN
bam-7218	165	10	,	,	PUNCT
bam-7218	165	11	italy	italy	PROPN
bam-7218	165	12	october	october	PROPN
bam-7218	165	13	12	12	NUM
bam-7218	165	14	-	-	SYM
bam-7218	165	15	15	15	NUM
bam-7218	165	16	,	,	PUNCT
bam-7218	165	17	2017	2017	NUM
bam-7218	165	18	.	.	PUNCT
bam-7218	166	1	lecture	lecture	VERB
bam-7218	166	2	1	1	NUM
bam-7218	166	3	breaking	break	VERB
bam-7218	166	4	news	news	NOUN
bam-7218	166	5	on	on	ADP
bam-7218	166	6	the	the	DET
bam-7218	166	7	regulation	regulation	NOUN
bam-7218	166	8	of	of	ADP
bam-7218	166	9	striated	striated	ADJ
bam-7218	166	10	muscle	muscle	NOUN
bam-7218	166	11	contraction	contraction	NOUN
bam-7218	166	12	:	:	PUNCT
bam-7218	166	13	thick	thick	ADJ
bam-7218	166	14	filament	filament	NOUN
bam-7218	166	15	participates	participate	VERB
bam-7218	166	16	!	!	PUNCT
bam-7218	167	1	marco	marco	PROPN
bam-7218	167	2	linari	linari	PROPN
bam-7218	167	3	university	university	PROPN
bam-7218	167	4	of	of	ADP
bam-7218	167	5	florence	florence	NOUN
bam-7218	167	6	,	,	PUNCT
bam-7218	167	7	italy	italy	PROPN
bam-7218	167	8	e	e	PROPN
bam-7218	167	9	-	-	NOUN
bam-7218	167	10	mail	mail	NOUN
bam-7218	167	11	:	:	PUNCT
bam-7218	167	12	marco.linari@unifi.it	marco.linari@unifi.it	NOUN
bam-7218	167	13	force	force	NOUN
bam-7218	167	14	and	and	CCONJ
bam-7218	167	15	shortening	shortening	NOUN
bam-7218	167	16	in	in	ADP
bam-7218	167	17	striated	striated	ADJ
bam-7218	167	18	(	(	PUNCT
bam-7218	167	19	skeletal	skeletal	ADJ
bam-7218	167	20	and	and	CCONJ
bam-7218	167	21	cardiac	cardiac	ADJ
bam-7218	167	22	)	)	PUNCT
bam-7218	167	23	muscles	muscle	NOUN
bam-7218	167	24	are	be	AUX
bam-7218	167	25	generated	generate	VERB
bam-7218	167	26	at	at	ADP
bam-7218	167	27	the	the	DET
bam-7218	167	28	level	level	NOUN
bam-7218	167	29	of	of	ADP
bam-7218	167	30	the	the	DET
bam-7218	167	31	sarcomere	sarcomere	NOUN
bam-7218	167	32	,	,	PUNCT
bam-7218	167	33	the	the	DET
bam-7218	167	34	structural	structural	ADJ
bam-7218	167	35	unit	unit	NOUN
bam-7218	167	36	,	,	PUNCT
bam-7218	167	37	by	by	ADP
bam-7218	167	38	the	the	DET
bam-7218	167	39	two	two	NUM
bam-7218	167	40	bipolar	bipolar	ADJ
bam-7218	167	41	arrays	array	NOUN
bam-7218	167	42	of	of	ADP
bam-7218	167	43	the	the	DET
bam-7218	167	44	motor	motor	NOUN
bam-7218	167	45	protein	protein	NOUN
bam-7218	167	46	myosin	myosin	PROPN
bam-7218	167	47	ii	ii	PROPN
bam-7218	167	48	emerging	emerge	VERB
bam-7218	167	49	from	from	ADP
bam-7218	167	50	the	the	DET
bam-7218	167	51	thick	thick	ADJ
bam-7218	167	52	filament	filament	NOUN
bam-7218	167	53	,	,	PUNCT
bam-7218	167	54	during	during	ADP
bam-7218	167	55	cyclical	cyclical	ADJ
bam-7218	167	56	interactions	interaction	NOUN
bam-7218	167	57	with	with	ADP
bam-7218	167	58	the	the	DET
bam-7218	167	59	interdigitating	interdigitate	VERB
bam-7218	167	60	thin	thin	ADJ
bam-7218	167	61	,	,	PUNCT
bam-7218	167	62	actin	actin	NOUN
bam-7218	167	63	-	-	PUNCT
bam-7218	167	64	containing	contain	VERB
bam-7218	167	65	,	,	PUNCT
bam-7218	167	66	filaments	filament	NOUN
bam-7218	167	67	.	.	PUNCT
bam-7218	168	1	in	in	ADP
bam-7218	168	2	the	the	DET
bam-7218	168	3	classical	classical	ADJ
bam-7218	168	4	model	model	NOUN
bam-7218	168	5	of	of	ADP
bam-7218	168	6	striated	striated	ADJ
bam-7218	168	7	muscle	muscle	NOUN
bam-7218	168	8	regulation	regulation	NOUN
bam-7218	168	9	the	the	DET
bam-7218	168	10	off	off	NOUN
bam-7218	168	11	(	(	PUNCT
bam-7218	168	12	resting	rest	VERB
bam-7218	168	13	)	)	PUNCT
bam-7218	168	14	and	and	CCONJ
bam-7218	168	15	on	on	ADP
bam-7218	168	16	(	(	PUNCT
bam-7218	168	17	actively	actively	ADV
bam-7218	168	18	contracting	contracting	NOUN
bam-7218	168	19	)	)	PUNCT
bam-7218	168	20	states	state	NOUN
bam-7218	168	21	of	of	ADP
bam-7218	168	22	muscle	muscle	NOUN
bam-7218	168	23	correspond	correspond	VERB
bam-7218	168	24	to	to	ADP
bam-7218	168	25	the	the	DET
bam-7218	168	26	off	off	NOUN
bam-7218	168	27	and	and	CCONJ
bam-7218	168	28	on	on	ADP
bam-7218	168	29	state	state	NOUN
bam-7218	168	30	of	of	ADP
bam-7218	168	31	the	the	DET
bam-7218	168	32	thin	thin	ADJ
bam-7218	168	33	filament	filament	NOUN
bam-7218	168	34	and	and	CCONJ
bam-7218	168	35	the	the	DET
bam-7218	168	36	switch	switch	NOUN
bam-7218	168	37	between	between	ADP
bam-7218	168	38	states	state	NOUN
bam-7218	168	39	is	be	AUX
bam-7218	168	40	controlled	control	VERB
bam-7218	168	41	by	by	ADP
bam-7218	168	42	calcium	calcium	NOUN
bam-7218	168	43	.	.	PUNCT
bam-7218	169	1	however	however	ADV
bam-7218	169	2	,	,	PUNCT
bam-7218	169	3	in	in	ADP
bam-7218	169	4	the	the	DET
bam-7218	169	5	resting	rest	VERB
bam-7218	169	6	muscle	muscle	NOUN
bam-7218	169	7	most	most	ADJ
bam-7218	169	8	of	of	ADP
bam-7218	169	9	the	the	DET
bam-7218	169	10	myosin	myosin	PROPN
bam-7218	169	11	motors	motors	PROPN
bam-7218	169	12	lie	lie	VERB
bam-7218	169	13	on	on	ADP
bam-7218	169	14	the	the	DET
bam-7218	169	15	surface	surface	NOUN
bam-7218	169	16	of	of	ADP
bam-7218	169	17	the	the	DET
bam-7218	169	18	thick	thick	ADJ
bam-7218	169	19	filament	filament	NOUN
bam-7218	169	20	folded	fold	VERB
bam-7218	169	21	back	back	ADV
bam-7218	169	22	against	against	ADP
bam-7218	169	23	the	the	DET
bam-7218	169	24	myosin	myosin	NOUN
bam-7218	169	25	tails	tail	NOUN
bam-7218	169	26	unavailable	unavailable	ADJ
bam-7218	169	27	for	for	ADP
bam-7218	169	28	binding	bind	VERB
bam-7218	169	29	to	to	ADP
bam-7218	169	30	the	the	DET
bam-7218	169	31	actin	actin	NOUN
bam-7218	169	32	(	(	PUNCT
bam-7218	169	33	woodhead	woodhead	PROPN
bam-7218	169	34	et	et	PROPN
bam-7218	169	35	al	al	PROPN
bam-7218	169	36	.	.	PROPN
bam-7218	169	37	nature	nature	PROPN
bam-7218	169	38	436:1195	436:1195	PROPN
bam-7218	169	39	,	,	PUNCT
bam-7218	169	40	2005	2005	NUM
bam-7218	169	41	;	;	PUNCT
bam-7218	169	42	zoghbi	zoghbi	PROPN
bam-7218	169	43	et	et	PROPN
bam-7218	169	44	al	al	PROPN
bam-7218	169	45	.	.	PUNCT
bam-7218	170	1	pnas	pnas	PROPN
bam-7218	170	2	105:2386	105:2386	NUM
bam-7218	170	3	,	,	PUNCT
bam-7218	170	4	2008	2008	NUM
bam-7218	170	5	)	)	PUNCT
bam-7218	170	6	and	and	CCONJ
bam-7218	170	7	splitting	split	VERB
bam-7218	170	8	atp	atp	PROPN
bam-7218	170	9	(	(	PUNCT
bam-7218	170	10	stewart	stewart	PROPN
bam-7218	170	11	et	et	PROPN
bam-7218	170	12	al	al	PROPN
bam-7218	170	13	.	.	PUNCT
bam-7218	171	1	pnas	pnas	PROPN
bam-7218	171	2	107:430	107:430	PROPN
bam-7218	171	3	,	,	PUNCT
bam-7218	171	4	2011	2011	NUM
bam-7218	171	5	)	)	PUNCT
bam-7218	171	6	(	(	PUNCT
bam-7218	171	7	off	off	ADP
bam-7218	171	8	state	state	NOUN
bam-7218	171	9	of	of	ADP
bam-7218	171	10	the	the	DET
bam-7218	171	11	thick	thick	ADJ
bam-7218	171	12	filament	filament	NOUN
bam-7218	171	13	)	)	PUNCT
bam-7218	171	14	.	.	PUNCT
bam-7218	172	1	this	this	PRON
bam-7218	172	2	implies	imply	VERB
bam-7218	172	3	the	the	DET
bam-7218	172	4	presence	presence	NOUN
bam-7218	172	5	of	of	ADP
bam-7218	172	6	a	a	DET
bam-7218	172	7	second	second	ADJ
bam-7218	172	8	thick	thick	ADV
bam-7218	172	9	-	-	PUNCT
bam-7218	172	10	filamentbased	filamentbase	VERB
bam-7218	172	11	switch	switch	NOUN
bam-7218	172	12	for	for	ADP
bam-7218	172	13	contraction	contraction	NOUN
bam-7218	172	14	:	:	PUNCT
bam-7218	172	15	muscle	muscle	NOUN
bam-7218	172	16	is	be	AUX
bam-7218	172	17	on	on	ADP
bam-7218	172	18	when	when	SCONJ
bam-7218	172	19	both	both	CCONJ
bam-7218	172	20	the	the	DET
bam-7218	172	21	thin	thin	ADJ
bam-7218	172	22	and	and	CCONJ
bam-7218	172	23	thick	thick	ADJ
bam-7218	172	24	filaments	filament	NOUN
bam-7218	172	25	are	be	AUX
bam-7218	172	26	on	on	ADP
bam-7218	172	27	.	.	PUNCT
bam-7218	173	1	to	to	PART
bam-7218	173	2	investigate	investigate	VERB
bam-7218	173	3	this	this	DET
bam-7218	173	4	point	point	NOUN
bam-7218	173	5	,	,	PUNCT
bam-7218	173	6	we	we	PRON
bam-7218	173	7	used	use	VERB
bam-7218	173	8	sarcomere	sarcomere	ADJ
bam-7218	173	9	-	-	PUNCT
bam-7218	173	10	level	level	NOUN
bam-7218	173	11	mechanics	mechanic	NOUN
bam-7218	173	12	and	and	CCONJ
bam-7218	173	13	x	x	NOUN
bam-7218	173	14	-	-	NOUN
bam-7218	173	15	ray	ray	NOUN
bam-7218	173	16	diffraction	diffraction	NOUN
bam-7218	173	17	interference	interference	NOUN
bam-7218	173	18	from	from	ADP
bam-7218	173	19	striated	striated	ADJ
bam-7218	173	20	muscle	muscle	NOUN
bam-7218	173	21	cells	cell	NOUN
bam-7218	173	22	at	at	ADP
bam-7218	173	23	id02	id02	PROPN
bam-7218	173	24	beamline	beamline	NOUN
bam-7218	173	25	of	of	ADP
bam-7218	173	26	the	the	DET
bam-7218	173	27	european	european	ADJ
bam-7218	173	28	synchrotron	synchrotron	NOUN
bam-7218	173	29	(	(	PUNCT
bam-7218	173	30	grenoble	grenoble	ADJ
bam-7218	173	31	,	,	PUNCT
bam-7218	173	32	france	france	PROPN
bam-7218	173	33	)	)	PUNCT
bam-7218	173	34	.	.	PUNCT
bam-7218	174	1	in	in	ADP
bam-7218	174	2	single	single	ADJ
bam-7218	174	3	intact	intact	ADJ
bam-7218	174	4	fibres	fibre	NOUN
bam-7218	174	5	from	from	ADP
bam-7218	174	6	frog	frog	ADJ
bam-7218	174	7	skeletal	skeletal	ADJ
bam-7218	174	8	muscle	muscle	NOUN
bam-7218	174	9	we	we	PRON
bam-7218	174	10	showed	show	VERB
bam-7218	174	11	that	that	SCONJ
bam-7218	174	12	,	,	PUNCT
bam-7218	174	13	for	for	ADP
bam-7218	174	14	contraction	contraction	NOUN
bam-7218	174	15	against	against	ADP
bam-7218	174	16	high	high	ADJ
bam-7218	174	17	loads	load	NOUN
bam-7218	174	18	,	,	PUNCT
bam-7218	174	19	the	the	DET
bam-7218	174	20	recruitment	recruitment	NOUN
bam-7218	174	21	of	of	ADP
bam-7218	174	22	myosin	myosin	PROPN
bam-7218	174	23	motors	motor	NOUN
bam-7218	174	24	from	from	ADP
bam-7218	174	25	the	the	DET
bam-7218	174	26	off	off	ADJ
bam-7218	174	27	state	state	NOUN
bam-7218	174	28	is	be	AUX
bam-7218	174	29	based	base	VERB
bam-7218	174	30	on	on	ADP
bam-7218	174	31	a	a	DET
bam-7218	174	32	stress	stress	NOUN
bam-7218	174	33	-	-	PUNCT
bam-7218	174	34	sensing	sense	VERB
bam-7218	174	35	mechanism	mechanism	NOUN
bam-7218	174	36	in	in	ADP
bam-7218	174	37	the	the	DET
bam-7218	174	38	thick	thick	ADJ
bam-7218	174	39	filament	filament	NOUN
bam-7218	174	40	and	and	CCONJ
bam-7218	174	41	that	that	SCONJ
bam-7218	174	42	during	during	ADP
bam-7218	174	43	unloaded	unload	VERB
bam-7218	174	44	shortening	shortening	NOUN
bam-7218	174	45	a	a	DET
bam-7218	174	46	large	large	ADJ
bam-7218	174	47	fraction	fraction	NOUN
bam-7218	174	48	of	of	ADP
bam-7218	174	49	motors	motor	NOUN
bam-7218	174	50	recovers	recover	VERB
bam-7218	174	51	progressively	progressively	ADV
bam-7218	174	52	the	the	DET
bam-7218	174	53	off	off	ADJ
bam-7218	174	54	state	state	NOUN
bam-7218	174	55	(	(	PUNCT
bam-7218	174	56	linari	linari	PROPN
bam-7218	174	57	et	et	PROPN
bam-7218	174	58	al	al	PROPN
bam-7218	174	59	.	.	PROPN
bam-7218	174	60	nature	nature	PROPN
bam-7218	174	61	,	,	PUNCT
bam-7218	174	62	528:276	528:276	NOUN
bam-7218	174	63	,	,	PUNCT
bam-7218	174	64	2015	2015	NUM
bam-7218	174	65	)	)	PUNCT
bam-7218	174	66	.	.	PUNCT
bam-7218	175	1	the	the	DET
bam-7218	175	2	role	role	NOUN
bam-7218	175	3	of	of	ADP
bam-7218	175	4	thick	thick	ADJ
bam-7218	175	5	filament	filament	NOUN
bam-7218	175	6	stress	stress	NOUN
bam-7218	175	7	-	-	PUNCT
bam-7218	175	8	sensing	sense	VERB
bam-7218	175	9	in	in	ADP
bam-7218	175	10	heartbeat	heartbeat	NOUN
bam-7218	175	11	regulation	regulation	NOUN
bam-7218	175	12	has	have	AUX
bam-7218	175	13	been	be	AUX
bam-7218	175	14	investigated	investigate	VERB
bam-7218	175	15	by	by	ADP
bam-7218	175	16	exploiting	exploit	VERB
bam-7218	175	17	our	our	PRON
bam-7218	175	18	recent	recent	ADJ
bam-7218	175	19	development	development	NOUN
bam-7218	175	20	of	of	ADP
bam-7218	175	21	sarcomere	sarcomere	ADJ
bam-7218	175	22	-	-	PUNCT
bam-7218	175	23	level	level	NOUN
bam-7218	175	24	mechanics	mechanic	NOUN
bam-7218	175	25	in	in	ADP
bam-7218	175	26	intact	intact	ADJ
bam-7218	175	27	trabeculae	trabeculae	NOUN
bam-7218	175	28	isolated	isolate	VERB
bam-7218	175	29	from	from	ADP
bam-7218	175	30	the	the	DET
bam-7218	175	31	ventricle	ventricle	NOUN
bam-7218	175	32	of	of	ADP
bam-7218	175	33	rat	rat	NOUN
bam-7218	175	34	heart	heart	NOUN
bam-7218	175	35	(	(	PUNCT
bam-7218	175	36	caremani	caremani	PROPN
bam-7218	175	37	et	et	PROPN
bam-7218	175	38	al	al	PROPN
bam-7218	175	39	.	.	PUNCT
bam-7218	176	1	pnas	pnas	PROPN
bam-7218	176	2	113:3675	113:3675	PROPN
bam-7218	176	3	,	,	PUNCT
bam-7218	176	4	2016	2016	NUM
bam-7218	176	5	)	)	PUNCT
bam-7218	176	6	and	and	CCONJ
bam-7218	176	7	the	the	DET
bam-7218	176	8	possibility	possibility	NOUN
bam-7218	176	9	at	at	ADP
bam-7218	176	10	id02	id02	PROPN
bam-7218	176	11	beamline	beamline	VERB
bam-7218	176	12	to	to	PART
bam-7218	176	13	record	record	VERB
bam-7218	176	14	both	both	CCONJ
bam-7218	176	15	the	the	DET
bam-7218	176	16	nanometer	nanometer	NOUN
bam-7218	176	17	-	-	PUNCT
bam-7218	176	18	scale	scale	NOUN
bam-7218	176	19	signals	signal	NOUN
bam-7218	176	20	from	from	ADP
bam-7218	176	21	the	the	DET
bam-7218	176	22	contractile	contractile	NOUN
bam-7218	176	23	proteins	protein	NOUN
bam-7218	176	24	along	along	ADP
bam-7218	176	25	the	the	DET
bam-7218	176	26	thick	thick	ADJ
bam-7218	176	27	filament	filament	NOUN
bam-7218	176	28	(	(	PUNCT
bam-7218	176	29	m1	m1	NOUN
bam-7218	176	30	-	-	PUNCT
bam-7218	176	31	m6	m6	PROPN
bam-7218	176	32	,	,	PUNCT
bam-7218	176	33	camera	camera	NOUN
bam-7218	176	34	length	length	NOUN
bam-7218	176	35	1.6	1.6	NUM
bam-7218	176	36	m	m	NOUN
bam-7218	176	37	)	)	PUNCT
bam-7218	176	38	and	and	CCONJ
bam-7218	176	39	the	the	DET
bam-7218	176	40	micrometer	micrometer	NOUN
bam-7218	176	41	-	-	PUNCT
bam-7218	176	42	scale	scale	NOUN
bam-7218	176	43	changes	change	NOUN
bam-7218	176	44	of	of	ADP
bam-7218	176	45	the	the	DET
bam-7218	176	46	length	length	NOUN
bam-7218	176	47	of	of	ADP
bam-7218	176	48	the	the	DET
bam-7218	176	49	sarcomere	sarcomere	NOUN
bam-7218	176	50	(	(	PUNCT
bam-7218	176	51	camera	camera	NOUN
bam-7218	176	52	length	length	NOUN
bam-7218	176	53	30	30	NUM
bam-7218	176	54	m	m	NOUN
bam-7218	176	55	)	)	PUNCT
bam-7218	176	56	.	.	PUNCT
bam-7218	177	1	it	it	PRON
bam-7218	177	2	was	be	AUX
bam-7218	177	3	found	find	VERB
bam-7218	177	4	that	that	SCONJ
bam-7218	177	5	,	,	PUNCT
bam-7218	177	6	starting	start	VERB
bam-7218	177	7	from	from	ADP
bam-7218	177	8	the	the	DET
bam-7218	177	9	same	same	ADJ
bam-7218	177	10	resting	resting	NOUN
bam-7218	177	11	sarcomere	sarcomere	NOUN
bam-7218	177	12	length	length	NOUN
bam-7218	177	13	,	,	PUNCT
bam-7218	177	14	at	at	ADP
bam-7218	177	15	the	the	DET
bam-7218	177	16	peak	peak	NOUN
bam-7218	177	17	of	of	ADP
bam-7218	177	18	the	the	DET
bam-7218	177	19	twitch	twitch	NOUN
bam-7218	177	20	force	force	NOUN
bam-7218	177	21	the	the	DET
bam-7218	177	22	intensity	intensity	NOUN
bam-7218	177	23	profile	profile	NOUN
bam-7218	177	24	of	of	ADP
bam-7218	177	25	the	the	DET
bam-7218	177	26	m3	m3	PROPN
bam-7218	177	27	reflection	reflection	NOUN
bam-7218	177	28	due	due	ADP
bam-7218	177	29	to	to	ADP
bam-7218	177	30	axial	axial	ADJ
bam-7218	177	31	repeat	repeat	NOUN
bam-7218	177	32	of	of	ADP
bam-7218	177	33	myosin	myosin	PROPN
bam-7218	177	34	motors	motors	PROPN
bam-7218	177	35	change	change	VERB
bam-7218	177	36	with	with	ADP
bam-7218	177	37	the	the	DET
bam-7218	177	38	loading	loading	NOUN
bam-7218	177	39	conditions	condition	NOUN
bam-7218	177	40	,	,	PUNCT
bam-7218	177	41	whether	whether	SCONJ
bam-7218	177	42	sarcomere	sarcomere	ADJ
bam-7218	177	43	shortening	shortening	NOUN
bam-7218	177	44	against	against	ADP
bam-7218	177	45	the	the	DET
bam-7218	177	46	end	end	NOUN
bam-7218	177	47	compliance	compliance	NOUN
bam-7218	177	48	during	during	ADP
bam-7218	177	49	force	force	NOUN
bam-7218	177	50	development	development	NOUN
bam-7218	177	51	is	be	AUX
bam-7218	177	52	allowed	allow	VERB
bam-7218	177	53	(	(	PUNCT
bam-7218	177	54	fixed	fix	VERB
bam-7218	177	55	end	end	NOUN
bam-7218	177	56	conditions	condition	NOUN
bam-7218	177	57	)	)	PUNCT
bam-7218	177	58	or	or	CCONJ
bam-7218	177	59	is	be	AUX
bam-7218	177	60	prevented	prevent	VERB
bam-7218	177	61	(	(	PUNCT
bam-7218	177	62	length	length	NOUN
bam-7218	177	63	clamp	clamp	NOUN
bam-7218	177	64	conditions	condition	NOUN
bam-7218	177	65	)	)	PUNCT
bam-7218	177	66	(	(	PUNCT
bam-7218	177	67	reconditi	reconditi	NOUN
bam-7218	177	68	et	et	PROPN
bam-7218	177	69	al	al	PROPN
bam-7218	177	70	.	.	PUNCT
bam-7218	178	1	pnas	pnas	PROPN
bam-7218	178	2	114:3240	114:3240	PROPN
bam-7218	178	3	,	,	PUNCT
bam-7218	178	4	2017	2017	NUM
bam-7218	178	5	)	)	PUNCT
bam-7218	178	6	.	.	PUNCT
bam-7218	179	1	the	the	DET
bam-7218	179	2	difference	difference	NOUN
bam-7218	179	3	in	in	ADP
bam-7218	179	4	m3	m3	PROPN
bam-7218	179	5	intensity	intensity	NOUN
bam-7218	179	6	profiles	profile	NOUN
bam-7218	179	7	indicates	indicate	VERB
bam-7218	179	8	that	that	SCONJ
bam-7218	179	9	,	,	PUNCT
bam-7218	179	10	during	during	ADP
bam-7218	179	11	a	a	DET
bam-7218	179	12	cardiac	cardiac	ADJ
bam-7218	179	13	twitch	twitch	NOUN
bam-7218	179	14	,	,	PUNCT
bam-7218	179	15	only	only	ADV
bam-7218	179	16	a	a	DET
bam-7218	179	17	fraction	fraction	NOUN
bam-7218	179	18	of	of	ADP
bam-7218	179	19	the	the	DET
bam-7218	179	20	motors	motor	NOUN
bam-7218	179	21	leaves	leave	VERB
bam-7218	179	22	the	the	DET
bam-7218	179	23	off	off	ADJ
bam-7218	179	24	state	state	NOUN
bam-7218	179	25	and	and	CCONJ
bam-7218	179	26	this	this	DET
bam-7218	179	27	fraction	fraction	NOUN
bam-7218	179	28	depends	depend	VERB
bam-7218	179	29	on	on	ADP
bam-7218	179	30	the	the	DET
bam-7218	179	31	level	level	NOUN
bam-7218	179	32	of	of	ADP
bam-7218	179	33	the	the	DET
bam-7218	179	34	force	force	NOUN
bam-7218	179	35	independently	independently	ADV
bam-7218	179	36	of	of	ADP
bam-7218	179	37	the	the	DET
bam-7218	179	38	diastolic	diastolic	NOUN
bam-7218	179	39	sarcomere	sarcomere	NOUN
bam-7218	179	40	length	length	NOUN
bam-7218	179	41	.	.	PUNCT
bam-7218	180	1	the	the	DET
bam-7218	180	2	different	different	ADJ
bam-7218	180	3	loading	loading	NOUN
bam-7218	180	4	conditions	condition	NOUN
bam-7218	180	5	of	of	ADP
bam-7218	180	6	the	the	DET
bam-7218	180	7	twitch	twitch	NOUN
bam-7218	180	8	reproduce	reproduce	VERB
bam-7218	180	9	the	the	DET
bam-7218	180	10	conditions	condition	NOUN
bam-7218	180	11	,	,	PUNCT
bam-7218	180	12	at	at	ADP
bam-7218	180	13	the	the	DET
bam-7218	180	14	organ	organ	NOUN
bam-7218	180	15	level	level	NOUN
bam-7218	180	16	,	,	PUNCT
bam-7218	180	17	of	of	ADP
bam-7218	180	18	the	the	DET
bam-7218	180	19	left	left	ADJ
bam-7218	180	20	ventricle	ventricle	NOUN
bam-7218	180	21	beating	beat	VERB
bam-7218	180	22	against	against	ADP
bam-7218	180	23	a	a	DET
bam-7218	180	24	high	high	ADJ
bam-7218	180	25	or	or	CCONJ
bam-7218	180	26	a	a	DET
bam-7218	180	27	low	low	ADJ
bam-7218	180	28	aortic	aortic	ADJ
bam-7218	180	29	pressure	pressure	NOUN
bam-7218	180	30	.	.	PUNCT
bam-7218	181	1	we	we	PRON
bam-7218	181	2	conclude	conclude	VERB
bam-7218	181	3	that	that	SCONJ
bam-7218	181	4	a	a	DET
bam-7218	181	5	stress	stress	NOUN
bam-7218	181	6	-	-	PUNCT
bam-7218	181	7	sensing	sense	VERB
bam-7218	181	8	mechanism	mechanism	NOUN
bam-7218	181	9	in	in	ADP
bam-7218	181	10	the	the	DET
bam-7218	181	11	heart	heart	NOUN
bam-7218	181	12	tunes	tune	VERB
bam-7218	181	13	the	the	DET
bam-7218	181	14	energetic	energetic	ADJ
bam-7218	181	15	cost	cost	NOUN
bam-7218	181	16	of	of	ADP
bam-7218	181	17	contraction	contraction	NOUN
bam-7218	181	18	to	to	ADP
bam-7218	181	19	the	the	DET
bam-7218	181	20	mechanical	mechanical	ADJ
bam-7218	181	21	task	task	NOUN
bam-7218	181	22	.	.	PUNCT
bam-7218	182	1	lecture	lecture	NOUN
bam-7218	182	2	2	2	NUM
bam-7218	182	3	the	the	DET
bam-7218	182	4	role	role	NOUN
bam-7218	182	5	of	of	ADP
bam-7218	182	6	endogenous	endogenous	ADJ
bam-7218	182	7	signals	signal	NOUN
bam-7218	182	8	in	in	ADP
bam-7218	182	9	cellular	cellular	ADJ
bam-7218	182	10	reprogramming	reprogramme	VERB
bam-7218	182	11	and	and	CCONJ
bam-7218	182	12	programming	programming	NOUN
bam-7218	182	13	nicola	nicola	PROPN
bam-7218	182	14	elvassore	elvassore	PROPN
bam-7218	182	15	vimm	vimm	PROPN
bam-7218	182	16	,	,	PUNCT
bam-7218	182	17	padova	padova	PROPN
bam-7218	182	18	,	,	PUNCT
bam-7218	182	19	italy	italy	PROPN
bam-7218	182	20	e	e	PROPN
bam-7218	182	21	-	-	NOUN
bam-7218	182	22	mail	mail	NOUN
bam-7218	182	23	:	:	PUNCT
bam-7218	182	24	nicola.elvassore@unipd.it	nicola.elvassore@unipd.it	PRON
bam-7218	182	25	mailto:marco.linari@unifi.it	mailto:marco.linari@unifi.it	NOUN
bam-7218	182	26	mailto:nicola.elvassore@unipd.it	mailto:nicola.elvassore@unipd.it	PROPN
bam-7218	182	27	14	14	NUM
bam-7218	182	28	th	th	NOUN
bam-7218	182	29	iiim	iiim	NOUN
bam-7218	182	30	meeting	meeting	NOUN
bam-7218	182	31	,	,	PUNCT
bam-7218	182	32	assisi	assisi	PROPN
bam-7218	182	33	,	,	PUNCT
bam-7218	182	34	italy	italy	PROPN
bam-7218	182	35	october	october	PROPN
bam-7218	182	36	12	12	NUM
bam-7218	182	37	-	-	SYM
bam-7218	182	38	15	15	NUM
bam-7218	182	39	2017	2017	NUM
bam-7218	182	40	eur	eur	PROPN
bam-7218	182	41	j	j	PROPN
bam-7218	182	42	transl	transl	PROPN
bam-7218	182	43	myol	myol	ADV
bam-7218	182	44	27	27	NUM
bam-7218	182	45	(	(	PUNCT
bam-7218	182	46	4	4	NUM
bam-7218	182	47	):	):	SYM
bam-7218	182	48	185	185	NUM
bam-7218	182	49	-	-	SYM
bam-7218	182	50	224	224	NUM
bam-7218	182	51	189	189	NUM
bam-7218	182	52	lecture	lecture	NOUN
bam-7218	182	53	3	3	NUM
bam-7218	182	54	transcriptional	transcriptional	ADJ
bam-7218	182	55	regulation	regulation	NOUN
bam-7218	182	56	of	of	ADP
bam-7218	182	57	skeletal	skeletal	ADJ
bam-7218	182	58	muscle	muscle	NOUN
bam-7218	182	59	function	function	NOUN
bam-7218	182	60	:	:	PUNCT
bam-7218	182	61	local	local	ADJ
bam-7218	182	62	and	and	CCONJ
bam-7218	182	63	systemic	systemic	ADJ
bam-7218	182	64	impact	impact	NOUN
bam-7218	182	65	jorge	jorge	PROPN
bam-7218	182	66	ruas	ruas	PROPN
bam-7218	182	67	karolinska	karolinska	PROPN
bam-7218	182	68	institute	institute	PROPN
bam-7218	182	69	,	,	PUNCT
bam-7218	182	70	stockholm	stockholm	PROPN
bam-7218	182	71	,	,	PUNCT
bam-7218	182	72	sweden	sweden	PROPN
bam-7218	182	73	e	e	NOUN
bam-7218	182	74	-	-	NOUN
bam-7218	182	75	mail	mail	NOUN
bam-7218	182	76	:	:	PUNCT
bam-7218	182	77	jorge.ruas@ki.se	jorge.ruas@ki.se	ADP
bam-7218	182	78	skeletal	skeletal	ADJ
bam-7218	182	79	muscle	muscle	NOUN
bam-7218	182	80	adapts	adapt	VERB
bam-7218	182	81	to	to	PART
bam-7218	182	82	exercise	exercise	VERB
bam-7218	182	83	training	training	NOUN
bam-7218	182	84	through	through	ADP
bam-7218	182	85	the	the	DET
bam-7218	182	86	concerted	concerted	ADJ
bam-7218	182	87	actions	action	NOUN
bam-7218	182	88	of	of	ADP
bam-7218	182	89	several	several	ADJ
bam-7218	182	90	transcriptional	transcriptional	ADJ
bam-7218	182	91	regulators	regulator	NOUN
bam-7218	182	92	,	,	PUNCT
bam-7218	182	93	among	among	ADP
bam-7218	182	94	which	which	PRON
bam-7218	182	95	pgc-1alpha	pgc-1alpha	NOUN
bam-7218	182	96	coactivators	coactivator	NOUN
bam-7218	182	97	play	play	VERB
bam-7218	182	98	a	a	DET
bam-7218	182	99	central	central	ADJ
bam-7218	182	100	role	role	NOUN
bam-7218	182	101	.	.	PUNCT
bam-7218	183	1	when	when	SCONJ
bam-7218	183	2	activated	activate	VERB
bam-7218	183	3	by	by	ADP
bam-7218	183	4	aerobic	aerobic	ADJ
bam-7218	183	5	exercise	exercise	NOUN
bam-7218	183	6	,	,	PUNCT
bam-7218	183	7	pgc-1alpha1	pgc-1alpha1	NOUN
bam-7218	183	8	induces	induce	VERB
bam-7218	183	9	genes	gene	NOUN
bam-7218	183	10	relevant	relevant	ADJ
bam-7218	183	11	to	to	ADP
bam-7218	183	12	mitochondrial	mitochondrial	ADJ
bam-7218	183	13	biogenesis	biogenesis	NOUN
bam-7218	183	14	,	,	PUNCT
bam-7218	183	15	adaptive	adaptive	ADJ
bam-7218	183	16	thermogenesis	thermogenesis	NOUN
bam-7218	183	17	,	,	PUNCT
bam-7218	183	18	lipid	lipid	NOUN
bam-7218	183	19	and	and	CCONJ
bam-7218	183	20	glucose	glucose	NOUN
bam-7218	183	21	homeostasis	homeostasis	NOUN
bam-7218	183	22	,	,	PUNCT
bam-7218	183	23	fiber	fiber	NOUN
bam-7218	183	24	-	-	PUNCT
bam-7218	183	25	type	type	NOUN
bam-7218	183	26	switching	switching	NOUN
bam-7218	183	27	,	,	PUNCT
bam-7218	183	28	among	among	ADP
bam-7218	183	29	other	other	ADJ
bam-7218	183	30	processes	process	NOUN
bam-7218	183	31	.	.	PUNCT
bam-7218	184	1	in	in	ADP
bam-7218	184	2	addition	addition	NOUN
bam-7218	184	3	,	,	PUNCT
bam-7218	184	4	exercised	exercise	VERB
bam-7218	184	5	skeletal	skeletal	ADJ
bam-7218	184	6	muscle	muscle	NOUN
bam-7218	184	7	promotes	promote	VERB
bam-7218	184	8	peripheral	peripheral	ADJ
bam-7218	184	9	kynurenine	kynurenine	NOUN
bam-7218	184	10	detoxification	detoxification	NOUN
bam-7218	184	11	,	,	PUNCT
bam-7218	184	12	which	which	PRON
bam-7218	184	13	protects	protect	VERB
bam-7218	184	14	from	from	ADP
bam-7218	184	15	stressinduced	stressinduced	ADJ
bam-7218	184	16	depression	depression	NOUN
bam-7218	184	17	.	.	PUNCT
bam-7218	185	1	metabolites	metabolite	NOUN
bam-7218	185	2	of	of	ADP
bam-7218	185	3	the	the	DET
bam-7218	185	4	kynurenine	kynurenine	NOUN
bam-7218	185	5	pathway	pathway	NOUN
bam-7218	185	6	of	of	ADP
bam-7218	185	7	tryptophan	tryptophan	NOUN
bam-7218	185	8	degradation	degradation	NOUN
bam-7218	185	9	play	play	VERB
bam-7218	185	10	important	important	ADJ
bam-7218	185	11	roles	role	NOUN
bam-7218	185	12	in	in	ADP
bam-7218	185	13	the	the	DET
bam-7218	185	14	regulation	regulation	NOUN
bam-7218	185	15	of	of	ADP
bam-7218	185	16	neuroinflammation	neuroinflammation	NOUN
bam-7218	185	17	and	and	CCONJ
bam-7218	185	18	mental	mental	ADJ
bam-7218	185	19	health	health	NOUN
bam-7218	185	20	.	.	PUNCT
bam-7218	186	1	this	this	DET
bam-7218	186	2	process	process	NOUN
bam-7218	186	3	is	be	AUX
bam-7218	186	4	mediated	mediate	VERB
bam-7218	186	5	by	by	ADP
bam-7218	186	6	pgc-1alpha1	pgc-1alpha1	PROPN
bam-7218	186	7	,	,	PUNCT
bam-7218	186	8	which	which	PRON
bam-7218	186	9	enhances	enhance	VERB
bam-7218	186	10	kynurenine	kynurenine	NOUN
bam-7218	186	11	aminotransferase	aminotransferase	PROPN
bam-7218	186	12	(	(	PUNCT
bam-7218	186	13	kat	kat	PROPN
bam-7218	186	14	)	)	PUNCT
bam-7218	186	15	gene	gene	NOUN
bam-7218	186	16	expression	expression	NOUN
bam-7218	186	17	in	in	ADP
bam-7218	186	18	skeletal	skeletal	ADJ
bam-7218	186	19	muscle	muscle	NOUN
bam-7218	186	20	.	.	PUNCT
bam-7218	187	1	elevated	elevated	PROPN
bam-7218	187	2	kat	kat	PROPN
bam-7218	187	3	levels	level	NOUN
bam-7218	187	4	convert	convert	VERB
bam-7218	187	5	accumulating	accumulate	VERB
bam-7218	187	6	kynurenine	kynurenine	NOUN
bam-7218	187	7	into	into	ADP
bam-7218	187	8	kynurenic	kynurenic	ADJ
bam-7218	187	9	acid	acid	NOUN
bam-7218	187	10	,	,	PUNCT
bam-7218	187	11	an	an	DET
bam-7218	187	12	end	end	NOUN
bam-7218	187	13	metabolite	metabolite	NOUN
bam-7218	187	14	of	of	ADP
bam-7218	187	15	the	the	DET
bam-7218	187	16	pathway	pathway	NOUN
bam-7218	187	17	that	that	PRON
bam-7218	187	18	can	can	AUX
bam-7218	187	19	not	not	PART
bam-7218	187	20	cross	cross	VERB
bam-7218	187	21	the	the	DET
bam-7218	187	22	blood	blood	NOUN
bam-7218	187	23	-	-	PUNCT
bam-7218	187	24	brain	brain	NOUN
bam-7218	187	25	barrier	barrier	NOUN
bam-7218	187	26	and	and	CCONJ
bam-7218	187	27	therefore	therefore	ADV
bam-7218	187	28	remains	remain	VERB
bam-7218	187	29	in	in	ADP
bam-7218	187	30	the	the	DET
bam-7218	187	31	periphery	periphery	NOUN
bam-7218	187	32	.	.	PUNCT
bam-7218	188	1	we	we	PRON
bam-7218	188	2	will	will	AUX
bam-7218	188	3	discuss	discuss	VERB
bam-7218	188	4	some	some	PRON
bam-7218	188	5	of	of	ADP
bam-7218	188	6	the	the	DET
bam-7218	188	7	consequences	consequence	NOUN
bam-7218	188	8	of	of	ADP
bam-7218	188	9	activating	activate	VERB
bam-7218	188	10	muscle	muscle	NOUN
bam-7218	188	11	kynurenine	kynurenine	NOUN
bam-7218	188	12	metabolism	metabolism	NOUN
bam-7218	188	13	for	for	ADP
bam-7218	188	14	peripheral	peripheral	ADJ
bam-7218	188	15	tissue	tissue	NOUN
bam-7218	188	16	inflammation	inflammation	NOUN
bam-7218	188	17	and	and	CCONJ
bam-7218	188	18	energy	energy	NOUN
bam-7218	188	19	expenditure	expenditure	NOUN
bam-7218	188	20	.	.	PUNCT
bam-7218	189	1	lecture	lecture	VERB
bam-7218	189	2	4	4	NUM
bam-7218	189	3	effect	effect	NOUN
bam-7218	189	4	of	of	ADP
bam-7218	189	5	exercise	exercise	NOUN
bam-7218	189	6	on	on	ADP
bam-7218	189	7	cellular	cellular	ADJ
bam-7218	189	8	senescence	senescence	NOUN
bam-7218	189	9	and	and	CCONJ
bam-7218	189	10	systemic	systemic	ADJ
bam-7218	189	11	mitochondrial	mitochondrial	ADJ
bam-7218	189	12	function	function	NOUN
bam-7218	189	13	mark	mark	PROPN
bam-7218	189	14	tarnopolsky	tarnopolsky	PROPN
bam-7218	189	15	mcmaster	mcmaster	PROPN
bam-7218	189	16	university	university	PROPN
bam-7218	189	17	medical	medical	ADJ
bam-7218	189	18	center	center	PROPN
bam-7218	189	19	,	,	PUNCT
bam-7218	189	20	hamilton	hamilton	PROPN
bam-7218	189	21	,	,	PUNCT
bam-7218	189	22	on	on	ADP
bam-7218	189	23	,	,	PUNCT
bam-7218	189	24	canada	canada	PROPN
bam-7218	189	25	e	e	PROPN
bam-7218	189	26	-	-	NOUN
bam-7218	189	27	mail	mail	NOUN
bam-7218	189	28	:	:	PUNCT
bam-7218	189	29	tarnopol@mcmaster.ca	tarnopol@mcmaster.ca	NOUN
bam-7218	189	30	human	human	ADJ
bam-7218	189	31	aging	aging	NOUN
bam-7218	189	32	is	be	AUX
bam-7218	189	33	associated	associate	VERB
bam-7218	189	34	with	with	ADP
bam-7218	189	35	an	an	DET
bam-7218	189	36	increase	increase	NOUN
bam-7218	189	37	in	in	ADP
bam-7218	189	38	the	the	DET
bam-7218	189	39	number	number	NOUN
bam-7218	189	40	of	of	ADP
bam-7218	189	41	senescent	senescent	ADJ
bam-7218	189	42	cells	cell	NOUN
bam-7218	189	43	in	in	ADP
bam-7218	189	44	a	a	DET
bam-7218	189	45	variety	variety	NOUN
bam-7218	189	46	of	of	ADP
bam-7218	189	47	tissues	tissue	NOUN
bam-7218	189	48	.	.	PUNCT
bam-7218	190	1	cellular	cellular	ADJ
bam-7218	190	2	senescence	senescence	NOUN
bam-7218	190	3	has	have	AUX
bam-7218	190	4	been	be	AUX
bam-7218	190	5	described	describe	VERB
bam-7218	190	6	in	in	ADP
bam-7218	190	7	vitro	vitro	X
bam-7218	190	8	as	as	ADP
bam-7218	190	9	the	the	DET
bam-7218	190	10	“	"	PUNCT
bam-7218	190	11	hayflick	hayflick	PROPN
bam-7218	190	12	phenomenon	phenomenon	NOUN
bam-7218	190	13	”	"	PUNCT
bam-7218	190	14	;	;	PUNCT
bam-7218	190	15	whereby	whereby	SCONJ
bam-7218	190	16	,	,	PUNCT
bam-7218	190	17	cells	cell	NOUN
bam-7218	190	18	fail	fail	VERB
bam-7218	190	19	to	to	PART
bam-7218	190	20	replicate	replicate	VERB
bam-7218	190	21	.	.	PUNCT
bam-7218	191	1	cellular	cellular	ADJ
bam-7218	191	2	senescence	senescence	NOUN
bam-7218	191	3	is	be	AUX
bam-7218	191	4	associated	associate	VERB
bam-7218	191	5	with	with	ADP
bam-7218	191	6	other	other	ADJ
bam-7218	191	7	canonical	canonical	ADJ
bam-7218	191	8	features	feature	NOUN
bam-7218	191	9	of	of	ADP
bam-7218	191	10	aging	age	VERB
bam-7218	191	11	such	such	ADJ
bam-7218	191	12	as	as	ADP
bam-7218	191	13	telomere	telomere	NOUN
bam-7218	191	14	shortening	shortening	NOUN
bam-7218	191	15	,	,	PUNCT
bam-7218	191	16	an	an	DET
bam-7218	191	17	increase	increase	NOUN
bam-7218	191	18	in	in	ADP
bam-7218	191	19	free	free	ADJ
bam-7218	191	20	radicals	radical	NOUN
bam-7218	191	21	/	/	SYM
bam-7218	191	22	reactive	reactive	ADJ
bam-7218	191	23	oxygen	oxygen	NOUN
bam-7218	191	24	species	specie	NOUN
bam-7218	191	25	,	,	PUNCT
bam-7218	191	26	mitochondrial	mitochondrial	ADJ
bam-7218	191	27	dysfunction	dysfunction	NOUN
bam-7218	191	28	and	and	CCONJ
bam-7218	191	29	an	an	DET
bam-7218	191	30	increase	increase	NOUN
bam-7218	191	31	in	in	ADP
bam-7218	191	32	inflammatory	inflammatory	ADJ
bam-7218	191	33	markers	marker	NOUN
bam-7218	191	34	.	.	PUNCT
bam-7218	192	1	the	the	DET
bam-7218	192	2	senescence	senescence	NOUN
bam-7218	192	3	associated	associate	VERB
bam-7218	192	4	secretory	secretory	NOUN
bam-7218	192	5	pattern	pattern	NOUN
bam-7218	192	6	(	(	PUNCT
bam-7218	192	7	sasp	sasp	NOUN
bam-7218	192	8	)	)	PUNCT
bam-7218	192	9	refers	refer	VERB
bam-7218	192	10	to	to	ADP
bam-7218	192	11	the	the	DET
bam-7218	192	12	propensity	propensity	NOUN
bam-7218	192	13	for	for	ADP
bam-7218	192	14	senescence	senescence	NOUN
bam-7218	192	15	cells	cell	NOUN
bam-7218	192	16	to	to	PART
bam-7218	192	17	release	release	VERB
bam-7218	192	18	pro	pro	ADJ
bam-7218	192	19	-	-	ADJ
bam-7218	192	20	inflammatory	inflammatory	ADJ
bam-7218	192	21	cytokines	cytokine	NOUN
bam-7218	192	22	(	(	PUNCT
bam-7218	192	23	il-1	il-1	X
bam-7218	192	24	alpha	alpha	NOUN
bam-7218	192	25	,	,	PUNCT
bam-7218	192	26	il-1	il-1	ADP
bam-7218	192	27	beta	beta	NOUN
bam-7218	192	28	,	,	PUNCT
bam-7218	192	29	il-6	il-6	NUM
bam-7218	192	30	,	,	PUNCT
bam-7218	192	31	il-13	il-13	NUM
bam-7218	192	32	)	)	PUNCT
bam-7218	192	33	,	,	PUNCT
bam-7218	192	34	proteases	protease	NOUN
bam-7218	192	35	(	(	PUNCT
bam-7218	192	36	pai-1	pai-1	X
bam-7218	192	37	,	,	PUNCT
bam-7218	192	38	mmp-3	mmp-3	NOUN
bam-7218	192	39	,	,	PUNCT
bam-7218	192	40	mmp-1	mmp-1	ADP
bam-7218	192	41	,	,	PUNCT
bam-7218	192	42	timp-1	timp-1	NUM
bam-7218	192	43	)	)	PUNCT
bam-7218	192	44	,	,	PUNCT
bam-7218	192	45	growth	growth	NOUN
bam-7218	192	46	factors	factor	NOUN
bam-7218	192	47	(	(	PUNCT
bam-7218	192	48	hepatocyte	hepatocyte	NOUN
bam-7218	192	49	growth	growth	NOUN
bam-7218	192	50	factor	factor	NOUN
bam-7218	192	51	,	,	PUNCT
bam-7218	192	52	basic	basic	ADJ
bam-7218	192	53	fibroblast	fibroblast	ADJ
bam-7218	192	54	growth	growth	NOUN
bam-7218	192	55	factor	factor	NOUN
bam-7218	192	56	,	,	PUNCT
bam-7218	192	57	vegf	vegf	PROPN
bam-7218	192	58	-	-	PUNCT
bam-7218	192	59	a	a	PROPN
bam-7218	192	60	,	,	PUNCT
bam-7218	192	61	hgf	hgf	PROPN
bam-7218	192	62	,	,	PUNCT
bam-7218	192	63	egf	egf	PROPN
bam-7218	192	64	)	)	PUNCT
bam-7218	192	65	and	and	CCONJ
bam-7218	192	66	chemokines	chemokine	NOUN
bam-7218	192	67	(	(	PUNCT
bam-7218	192	68	il-8	il-8	NOUN
bam-7218	192	69	,	,	PUNCT
bam-7218	192	70	ccl2	ccl2	PROPN
bam-7218	192	71	,	,	PUNCT
bam-7218	192	72	cxcl	cxcl	NOUN
bam-7218	192	73	,	,	PUNCT
bam-7218	192	74	eotaxin	eotaxin	PROPN
bam-7218	192	75	,	,	PUNCT
bam-7218	192	76	eotaxin-3	eotaxin-3	PROPN
bam-7218	192	77	,	,	PUNCT
bam-7218	192	78	mcp2	mcp2	NOUN
bam-7218	192	79	,	,	PUNCT
bam-7218	192	80	il-8	il-8	NOUN
bam-7218	192	81	,	,	PUNCT
bam-7218	192	82	mip1a	mip1a	NOUN
bam-7218	192	83	)	)	PUNCT
bam-7218	192	84	.	.	PUNCT
bam-7218	193	1	we	we	PRON
bam-7218	193	2	and	and	CCONJ
bam-7218	193	3	others	other	NOUN
bam-7218	193	4	have	have	AUX
bam-7218	193	5	found	find	VERB
bam-7218	193	6	that	that	SCONJ
bam-7218	193	7	the	the	DET
bam-7218	193	8	basal	basal	ADJ
bam-7218	193	9	concentration	concentration	NOUN
bam-7218	193	10	of	of	ADP
bam-7218	193	11	many	many	ADJ
bam-7218	193	12	of	of	ADP
bam-7218	193	13	the	the	DET
bam-7218	193	14	constituents	constituent	NOUN
bam-7218	193	15	of	of	ADP
bam-7218	193	16	the	the	DET
bam-7218	193	17	sasp	sasp	NOUN
bam-7218	193	18	are	be	AUX
bam-7218	193	19	higher	high	ADJ
bam-7218	193	20	in	in	ADP
bam-7218	193	21	older	old	ADJ
bam-7218	193	22	humans	human	NOUN
bam-7218	193	23	and	and	CCONJ
bam-7218	193	24	mice	mouse	NOUN
bam-7218	193	25	and	and	CCONJ
bam-7218	193	26	are	be	AUX
bam-7218	193	27	higher	high	ADJ
bam-7218	193	28	in	in	ADP
bam-7218	193	29	progeroid	progeroid	ADJ
bam-7218	193	30	aging	age	VERB
bam-7218	193	31	(	(	PUNCT
bam-7218	193	32	polymerase	polymerase	NOUN
bam-7218	193	33	gamma-1	gamma-1	NOUN
bam-7218	193	34	mutator	mutator	NOUN
bam-7218	193	35	mouse	mouse	NOUN
bam-7218	193	36	model	model	NOUN
bam-7218	193	37	)	)	PUNCT
bam-7218	193	38	.	.	PUNCT
bam-7218	194	1	our	our	PRON
bam-7218	194	2	recent	recent	ADJ
bam-7218	194	3	data	datum	NOUN
bam-7218	194	4	shows	show	VERB
bam-7218	194	5	that	that	SCONJ
bam-7218	194	6	fibroblasts	fibroblast	NOUN
bam-7218	194	7	from	from	ADP
bam-7218	194	8	older	old	ADJ
bam-7218	194	9	adults	adult	NOUN
bam-7218	194	10	have	have	VERB
bam-7218	194	11	far	far	ADV
bam-7218	194	12	fewer	few	ADJ
bam-7218	194	13	replicate	replicate	ADJ
bam-7218	194	14	cycles	cycle	NOUN
bam-7218	194	15	than	than	ADP
bam-7218	194	16	those	those	PRON
bam-7218	194	17	derived	derive	VERB
bam-7218	194	18	from	from	ADP
bam-7218	194	19	younger	young	ADJ
bam-7218	194	20	adults	adult	NOUN
bam-7218	194	21	and	and	CCONJ
bam-7218	194	22	older	old	ADJ
bam-7218	194	23	athletes	athlete	NOUN
bam-7218	194	24	are	be	AUX
bam-7218	194	25	similar	similar	ADJ
bam-7218	194	26	to	to	ADP
bam-7218	194	27	the	the	DET
bam-7218	194	28	young	young	ADJ
bam-7218	194	29	sedentary	sedentary	ADJ
bam-7218	194	30	adults	adult	NOUN
bam-7218	194	31	.	.	PUNCT
bam-7218	195	1	furthermore	furthermore	ADV
bam-7218	195	2	,	,	PUNCT
bam-7218	195	3	fibroblasts	fibroblast	NOUN
bam-7218	195	4	taken	take	VERB
bam-7218	195	5	from	from	ADP
bam-7218	195	6	sedentary	sedentary	ADJ
bam-7218	195	7	older	old	ADJ
bam-7218	195	8	adults	adult	NOUN
bam-7218	195	9	have	have	VERB
bam-7218	195	10	greater	great	ADJ
bam-7218	195	11	number	number	NOUN
bam-7218	195	12	of	of	ADP
bam-7218	195	13	passages	passage	NOUN
bam-7218	195	14	until	until	ADP
bam-7218	195	15	cellular	cellular	ADJ
bam-7218	195	16	senescence	senescence	NOUN
bam-7218	195	17	following	follow	VERB
bam-7218	195	18	three	three	NUM
bam-7218	195	19	months	month	NOUN
bam-7218	195	20	of	of	ADP
bam-7218	195	21	endurance	endurance	NOUN
bam-7218	195	22	exercise	exercise	NOUN
bam-7218	195	23	training	training	NOUN
bam-7218	195	24	.	.	PUNCT
bam-7218	196	1	we	we	PRON
bam-7218	196	2	and	and	CCONJ
bam-7218	196	3	others	other	NOUN
bam-7218	196	4	have	have	AUX
bam-7218	196	5	shown	show	VERB
bam-7218	196	6	improvements	improvement	NOUN
bam-7218	196	7	in	in	ADP
bam-7218	196	8	mitochondrial	mitochondrial	ADJ
bam-7218	196	9	function	function	NOUN
bam-7218	196	10	and	and	CCONJ
bam-7218	196	11	lower	low	ADJ
bam-7218	196	12	oxidative	oxidative	ADJ
bam-7218	196	13	stress	stress	NOUN
bam-7218	196	14	in	in	ADP
bam-7218	196	15	both	both	DET
bam-7218	196	16	cross	cross	VERB
bam-7218	196	17	sectional	sectional	ADJ
bam-7218	196	18	and	and	CCONJ
bam-7218	196	19	longitudinal	longitudinal	ADJ
bam-7218	196	20	studies	study	NOUN
bam-7218	196	21	in	in	ADP
bam-7218	196	22	humans	human	NOUN
bam-7218	196	23	and	and	CCONJ
bam-7218	196	24	mice	mouse	NOUN
bam-7218	196	25	.	.	PUNCT
bam-7218	197	1	acute	acute	ADJ
bam-7218	197	2	endurance	endurance	NOUN
bam-7218	197	3	exercise	exercise	NOUN
bam-7218	197	4	often	often	ADV
bam-7218	197	5	leads	lead	VERB
bam-7218	197	6	to	to	ADP
bam-7218	197	7	a	a	DET
bam-7218	197	8	“	"	PUNCT
bam-7218	197	9	pulse	pulse	NOUN
bam-7218	197	10	”	"	PUNCT
bam-7218	197	11	of	of	ADP
bam-7218	197	12	higher	high	ADJ
bam-7218	197	13	sasp	sasp	NOUN
bam-7218	197	14	components	component	NOUN
bam-7218	197	15	;	;	PUNCT
bam-7218	197	16	however	however	ADV
bam-7218	197	17	,	,	PUNCT
bam-7218	197	18	long	long	ADJ
bam-7218	197	19	term	term	NOUN
bam-7218	197	20	endurance	endurance	NOUN
bam-7218	197	21	training	training	NOUN
bam-7218	197	22	leads	lead	VERB
bam-7218	197	23	to	to	ADP
bam-7218	197	24	a	a	DET
bam-7218	197	25	lower	low	ADJ
bam-7218	197	26	basal	basal	NOUN
bam-7218	197	27	level	level	NOUN
bam-7218	197	28	of	of	ADP
bam-7218	197	29	sasp	sasp	NOUN
bam-7218	197	30	.	.	PUNCT
bam-7218	198	1	given	give	VERB
bam-7218	198	2	that	that	SCONJ
bam-7218	198	3	the	the	DET
bam-7218	198	4	consistent	consistent	ADJ
bam-7218	198	5	observation	observation	NOUN
bam-7218	198	6	of	of	ADP
bam-7218	198	7	increased	increase	VERB
bam-7218	198	8	mitochondrial	mitochondrial	ADJ
bam-7218	198	9	function	function	NOUN
bam-7218	198	10	and	and	CCONJ
bam-7218	198	11	lower	low	ADJ
bam-7218	198	12	oxidative	oxidative	ADJ
bam-7218	198	13	stress	stress	NOUN
bam-7218	198	14	in	in	ADP
bam-7218	198	15	endurance	endurance	NOUN
bam-7218	198	16	trained	train	VERB
bam-7218	198	17	mice	mouse	NOUN
bam-7218	198	18	and	and	CCONJ
bam-7218	198	19	humans	human	NOUN
bam-7218	198	20	and	and	CCONJ
bam-7218	198	21	the	the	DET
bam-7218	198	22	importance	importance	NOUN
bam-7218	198	23	of	of	ADP
bam-7218	198	24	mitochondria	mitochondria	NOUN
bam-7218	198	25	to	to	ADP
bam-7218	198	26	senescence	senescence	NOUN
bam-7218	198	27	pathways	pathway	NOUN
bam-7218	198	28	(	(	PUNCT
bam-7218	198	29	telomere	telomere	NOUN
bam-7218	198	30	length	length	NOUN
bam-7218	198	31	,	,	PUNCT
bam-7218	198	32	oxidative	oxidative	ADJ
bam-7218	198	33	stress	stress	NOUN
bam-7218	198	34	,	,	PUNCT
bam-7218	198	35	inflammasome	inflammasome	VERB
bam-7218	198	36	activation	activation	NOUN
bam-7218	198	37	)	)	PUNCT
bam-7218	199	1	i	i	PRON
bam-7218	199	2	posit	posit	VERB
bam-7218	199	3	that	that	SCONJ
bam-7218	199	4	mitochondrial	mitochondrial	ADJ
bam-7218	199	5	function	function	NOUN
bam-7218	199	6	is	be	AUX
bam-7218	199	7	the	the	DET
bam-7218	199	8	main	main	ADJ
bam-7218	199	9	factor	factor	NOUN
bam-7218	199	10	influenced	influence	VERB
bam-7218	199	11	by	by	ADP
bam-7218	199	12	exercise	exercise	NOUN
bam-7218	199	13	training	training	NOUN
bam-7218	199	14	that	that	PRON
bam-7218	199	15	leads	lead	VERB
bam-7218	199	16	to	to	ADP
bam-7218	199	17	a	a	DET
bam-7218	199	18	reduction	reduction	NOUN
bam-7218	199	19	in	in	ADP
bam-7218	199	20	sasp	sasp	NOUN
bam-7218	199	21	and	and	CCONJ
bam-7218	199	22	fewer	few	ADJ
bam-7218	199	23	senescence	senescence	NOUN
bam-7218	199	24	cells	cell	NOUN
bam-7218	199	25	.	.	PUNCT
bam-7218	200	1	october	october	PROPN
bam-7218	200	2	12	12	NUM
bam-7218	200	3	th	th	NOUN
bam-7218	200	4	session	session	NOUN
bam-7218	200	5	1	1	NUM
bam-7218	200	6	.	.	PUNCT
bam-7218	201	1	signaling	signal	VERB
bam-7218	201	2	in	in	ADP
bam-7218	201	3	muscle	muscle	NOUN
bam-7218	201	4	growth	growth	NOUN
bam-7218	201	5	,	,	PUNCT
bam-7218	201	6	homeostasis	homeostasis	NOUN
bam-7218	201	7	and	and	CCONJ
bam-7218	201	8	diseases	disease	NOUN
bam-7218	201	9	1.1	1.1	NUM
bam-7218	201	10	sh3bp2	sh3bp2	NOUN
bam-7218	201	11	as	as	ADP
bam-7218	201	12	a	a	DET
bam-7218	201	13	novel	novel	ADJ
bam-7218	201	14	scaffold	scaffold	NOUN
bam-7218	201	15	protein	protein	NOUN
bam-7218	201	16	regulating	regulate	VERB
bam-7218	201	17	muscle	muscle	NOUN
bam-7218	201	18	postsynaptic	postsynaptic	ADJ
bam-7218	201	19	machinery	machinery	NOUN
bam-7218	201	20	krzysztof	krzysztof	PROPN
bam-7218	201	21	marian	marian	PROPN
bam-7218	201	22	bernadzki	bernadzki	PROPN
bam-7218	201	23	,	,	PUNCT
bam-7218	201	24	marta	marta	PROPN
bam-7218	201	25	gawor	gawor	PROPN
bam-7218	201	26	,	,	PUNCT
bam-7218	201	27	paweł	paweł	VERB
bam-7218	201	28	niewiadomski	niewiadomski	PROPN
bam-7218	201	29	,	,	PUNCT
bam-7218	201	30	bhola	bhola	PROPN
bam-7218	201	31	shankar	shankar	PROPN
bam-7218	201	32	pradhan	pradhan	PROPN
bam-7218	201	33	,	,	PUNCT
bam-7218	201	34	tomasz	tomasz	PROPN
bam-7218	201	35	jacek	jacek	PROPN
bam-7218	201	36	prószyński	prószyński	PROPN
bam-7218	201	37	nencki	nencki	PROPN
bam-7218	201	38	institute	institute	PROPN
bam-7218	201	39	of	of	ADP
bam-7218	201	40	experimental	experimental	ADJ
bam-7218	201	41	biology	biology	NOUN
bam-7218	201	42	pas	pas	NOUN
bam-7218	201	43	,	,	PUNCT
bam-7218	201	44	laboratory	laboratory	NOUN
bam-7218	201	45	of	of	ADP
bam-7218	201	46	synaptogenesis	synaptogenesis	NOUN
bam-7218	201	47	,	,	PUNCT
bam-7218	201	48	poland	poland	PROPN
bam-7218	201	49	.	.	PUNCT
bam-7218	202	1	e	e	X
bam-7218	202	2	-	-	NOUN
bam-7218	202	3	mail	mail	NOUN
bam-7218	202	4	:	:	PUNCT
bam-7218	202	5	k.bernadzki@nencki.gov.pl	k.bernadzki@nencki.gov.pl	PROPN
bam-7218	202	6	neuromuscular	neuromuscular	ADJ
bam-7218	202	7	junctions	junction	NOUN
bam-7218	202	8	(	(	PUNCT
bam-7218	202	9	nmjs	nmj	NOUN
bam-7218	202	10	)	)	PUNCT
bam-7218	202	11	are	be	AUX
bam-7218	202	12	synapses	synapsis	NOUN
bam-7218	202	13	formed	form	VERB
bam-7218	202	14	between	between	ADP
bam-7218	202	15	motor	motor	NOUN
bam-7218	202	16	neurons	neuron	NOUN
bam-7218	202	17	and	and	CCONJ
bam-7218	202	18	skeletal	skeletal	ADJ
bam-7218	202	19	muscle	muscle	NOUN
bam-7218	202	20	fibers	fiber	NOUN
bam-7218	202	21	.	.	PUNCT
bam-7218	203	1	abnormalities	abnormality	NOUN
bam-7218	203	2	in	in	ADP
bam-7218	203	3	nmj	nmj	PROPN
bam-7218	203	4	development	development	NOUN
bam-7218	203	5	lead	lead	NOUN
bam-7218	203	6	to	to	ADP
bam-7218	203	7	various	various	ADJ
bam-7218	203	8	neuromuscular	neuromuscular	ADJ
bam-7218	203	9	disorders	disorder	NOUN
bam-7218	203	10	,	,	PUNCT
bam-7218	203	11	which	which	PRON
bam-7218	203	12	are	be	AUX
bam-7218	203	13	often	often	ADV
bam-7218	203	14	fatal	fatal	ADJ
bam-7218	203	15	.	.	PUNCT
bam-7218	204	1	despite	despite	SCONJ
bam-7218	204	2	their	their	PRON
bam-7218	204	3	crucial	crucial	ADJ
bam-7218	204	4	role	role	NOUN
bam-7218	204	5	,	,	PUNCT
bam-7218	204	6	the	the	DET
bam-7218	204	7	mechanisms	mechanism	NOUN
bam-7218	204	8	that	that	PRON
bam-7218	204	9	orchestrate	orchestrate	VERB
bam-7218	204	10	nmj	nmj	NOUN
bam-7218	204	11	development	development	NOUN
bam-7218	204	12	are	be	AUX
bam-7218	204	13	still	still	ADV
bam-7218	204	14	poorly	poorly	ADV
bam-7218	204	15	understood	understand	VERB
bam-7218	204	16	.	.	PUNCT
bam-7218	205	1	the	the	DET
bam-7218	205	2	dystrophin	dystrophin	NOUN
bam-7218	205	3	-	-	PUNCT
bam-7218	205	4	associated	associate	VERB
bam-7218	205	5	glycoprotein	glycoprotein	NOUN
bam-7218	205	6	complex	complex	NOUN
bam-7218	205	7	(	(	PUNCT
bam-7218	205	8	dgc	dgc	NOUN
bam-7218	205	9	)	)	PUNCT
bam-7218	205	10	is	be	AUX
bam-7218	205	11	a	a	DET
bam-7218	205	12	major	major	ADJ
bam-7218	205	13	laminin	laminin	NOUN
bam-7218	205	14	receptor	receptor	NOUN
bam-7218	205	15	in	in	ADP
bam-7218	205	16	the	the	DET
bam-7218	205	17	muscle	muscle	NOUN
bam-7218	205	18	required	require	VERB
bam-7218	205	19	for	for	ADP
bam-7218	205	20	proper	proper	ADJ
bam-7218	205	21	development	development	NOUN
bam-7218	205	22	of	of	ADP
bam-7218	205	23	the	the	DET
bam-7218	205	24	postsynaptic	postsynaptic	ADJ
bam-7218	205	25	machinery	machinery	NOUN
bam-7218	205	26	by	by	ADP
bam-7218	205	27	linking	link	VERB
bam-7218	205	28	its	its	PRON
bam-7218	205	29	components	component	NOUN
bam-7218	205	30	to	to	ADP
bam-7218	205	31	the	the	DET
bam-7218	205	32	extracellular	extracellular	ADJ
bam-7218	205	33	matrix	matrix	NOUN
bam-7218	205	34	and	and	CCONJ
bam-7218	205	35	the	the	DET
bam-7218	205	36	actin	actin	NOUN
bam-7218	205	37	cytoskeleton	cytoskeleton	PROPN
bam-7218	205	38	.	.	PUNCT
bam-7218	206	1	one	one	NUM
bam-7218	206	2	of	of	ADP
bam-7218	206	3	the	the	DET
bam-7218	206	4	cytoplasmic	cytoplasmic	ADJ
bam-7218	206	5	dgcassociated	dgcassociate	VERB
bam-7218	206	6	proteins	protein	NOUN
bam-7218	206	7	,	,	PUNCT
bam-7218	206	8	α	α	X
bam-7218	206	9	-	-	PUNCT
bam-7218	206	10	dystrobrevin-1	dystrobrevin-1	PUNCT
bam-7218	206	11	(	(	PUNCT
bam-7218	206	12	αdb1	αdb1	PROPN
bam-7218	206	13	)	)	PUNCT
bam-7218	206	14	,	,	PUNCT
bam-7218	206	15	was	be	AUX
bam-7218	206	16	shown	show	VERB
bam-7218	206	17	to	to	PART
bam-7218	206	18	play	play	VERB
bam-7218	206	19	an	an	DET
bam-7218	206	20	important	important	ADJ
bam-7218	206	21	role	role	NOUN
bam-7218	206	22	in	in	ADP
bam-7218	206	23	the	the	DET
bam-7218	206	24	organization	organization	NOUN
bam-7218	206	25	of	of	ADP
bam-7218	206	26	the	the	DET
bam-7218	206	27	nmj	nmj	PROPN
bam-7218	206	28	postsynaptic	postsynaptic	ADJ
bam-7218	206	29	machinery	machinery	NOUN
bam-7218	206	30	.	.	PUNCT
bam-7218	207	1	for	for	SCONJ
bam-7218	207	2	it	it	PRON
bam-7218	207	3	’s	’	VERB
bam-7218	207	4	proper	proper	ADJ
bam-7218	207	5	functioning	function	VERB
bam-7218	207	6	αdb1	αdb1	NOUN
bam-7218	207	7	needs	need	VERB
bam-7218	207	8	to	to	PART
bam-7218	207	9	be	be	AUX
bam-7218	207	10	phosphorylated	phosphorylate	VERB
bam-7218	207	11	on	on	ADP
bam-7218	207	12	its	its	PRON
bam-7218	207	13	cterminal	cterminal	ADJ
bam-7218	207	14	fragment	fragment	NOUN
bam-7218	207	15	.	.	PUNCT
bam-7218	208	1	to	to	PART
bam-7218	208	2	gain	gain	VERB
bam-7218	208	3	insight	insight	NOUN
bam-7218	208	4	into	into	ADP
bam-7218	208	5	the	the	DET
bam-7218	208	6	molecular	molecular	ADJ
bam-7218	208	7	mechanism	mechanism	NOUN
bam-7218	208	8	of	of	ADP
bam-7218	208	9	αdb1	αdb1	NOUN
bam-7218	208	10	function	function	NOUN
bam-7218	208	11	we	we	PRON
bam-7218	208	12	have	have	AUX
bam-7218	208	13	recently	recently	ADV
bam-7218	208	14	performed	perform	VERB
bam-7218	208	15	a	a	DET
bam-7218	208	16	biochemical	biochemical	ADJ
bam-7218	208	17	screen	screen	NOUN
bam-7218	208	18	for	for	ADP
bam-7218	208	19	phospho	phospho	ADJ
bam-7218	208	20	-	-	PUNCT
bam-7218	208	21	specific	specific	ADJ
bam-7218	208	22	interacting	interact	VERB
bam-7218	208	23	proteins	protein	NOUN
bam-7218	208	24	and	and	CCONJ
bam-7218	208	25	identified	identify	VERB
bam-7218	208	26	sh3bp2	sh3bp2	NOUN
bam-7218	208	27	as	as	ADP
bam-7218	208	28	a	a	DET
bam-7218	208	29	binding	bind	VERB
bam-7218	208	30	partner	partner	NOUN
bam-7218	208	31	.	.	PUNCT
bam-7218	209	1	sh3bp2	sh3bp2	PROPN
bam-7218	209	2	is	be	AUX
bam-7218	209	3	a	a	DET
bam-7218	209	4	scaffold	scaffold	NOUN
bam-7218	209	5	protein	protein	NOUN
bam-7218	209	6	with	with	ADP
bam-7218	209	7	unknown	unknown	ADJ
bam-7218	209	8	localization	localization	NOUN
bam-7218	209	9	and	and	CCONJ
bam-7218	209	10	function	function	NOUN
bam-7218	209	11	in	in	ADP
bam-7218	209	12	skeletal	skeletal	ADJ
bam-7218	209	13	muscles	muscle	NOUN
bam-7218	209	14	.	.	PUNCT
bam-7218	210	1	we	we	PRON
bam-7218	210	2	demonstrate	demonstrate	VERB
bam-7218	210	3	that	that	SCONJ
bam-7218	210	4	sh3bp2	sh3bp2	NOUN
bam-7218	210	5	is	be	AUX
bam-7218	210	6	concentrated	concentrate	VERB
bam-7218	210	7	at	at	ADP
bam-7218	210	8	the	the	DET
bam-7218	210	9	nmj	nmj	ADJ
bam-7218	210	10	postsynaptic	postsynaptic	ADJ
bam-7218	210	11	machinery	machinery	NOUN
bam-7218	210	12	and	and	CCONJ
bam-7218	210	13	also	also	ADV
bam-7218	210	14	at	at	ADP
bam-7218	210	15	the	the	DET
bam-7218	210	16	muscle	muscle	NOUN
bam-7218	210	17	mailto:jorge.ruas@ki.se	mailto:jorge.ruas@ki.se	NOUN
bam-7218	210	18	mailto:tarnopol@mcmaster.ca	mailto:tarnopol@mcmaster.ca	ADV
bam-7218	210	19	mailto:k.bernadzki@nencki.gov.pl	mailto:k.bernadzki@nencki.gov.pl	PROPN
bam-7218	210	20	14	14	NUM
bam-7218	210	21	th	th	NOUN
bam-7218	210	22	iiim	iiim	NOUN
bam-7218	210	23	meeting	meeting	NOUN
bam-7218	210	24	,	,	PUNCT
bam-7218	210	25	assisi	assisi	PROPN
bam-7218	210	26	,	,	PUNCT
bam-7218	210	27	italy	italy	PROPN
bam-7218	210	28	october	october	PROPN
bam-7218	210	29	12	12	NUM
bam-7218	210	30	-	-	SYM
bam-7218	210	31	15	15	NUM
bam-7218	210	32	2017	2017	NUM
bam-7218	210	33	eur	eur	PROPN
bam-7218	210	34	j	j	PROPN
bam-7218	210	35	transl	transl	PROPN
bam-7218	210	36	myol	myol	ADV
bam-7218	210	37	27	27	NUM
bam-7218	210	38	(	(	PUNCT
bam-7218	210	39	4	4	NUM
bam-7218	210	40	):	):	SYM
bam-7218	210	41	185	185	NUM
bam-7218	210	42	-	-	SYM
bam-7218	210	43	224	224	NUM
bam-7218	210	44	190	190	NUM
bam-7218	210	45	contractile	contractile	NOUN
bam-7218	210	46	machinery	machinery	NOUN
bam-7218	210	47	.	.	PUNCT
bam-7218	211	1	cultured	cultured	ADJ
bam-7218	211	2	myotubes	myotube	NOUN
bam-7218	211	3	depleted	deplete	VERB
bam-7218	211	4	of	of	ADP
bam-7218	211	5	sh3bp2	sh3bp2	NOUN
bam-7218	211	6	had	have	VERB
bam-7218	211	7	the	the	DET
bam-7218	211	8	impaired	impaired	ADJ
bam-7218	211	9	ability	ability	NOUN
bam-7218	211	10	to	to	PART
bam-7218	211	11	cluster	cluster	NOUN
bam-7218	211	12	achrs	achrs	PROPN
bam-7218	211	13	.	.	PUNCT
bam-7218	212	1	a	a	DET
bam-7218	212	2	similar	similar	ADJ
bam-7218	212	3	phenotype	phenotype	NOUN
bam-7218	212	4	was	be	AUX
bam-7218	212	5	observed	observe	VERB
bam-7218	212	6	at	at	ADP
bam-7218	212	7	the	the	DET
bam-7218	212	8	nmj	nmj	NOUN
bam-7218	212	9	upon	upon	SCONJ
bam-7218	212	10	muscles	muscle	NOUN
bam-7218	212	11	-	-	PUNCT
bam-7218	212	12	specific	specific	ADJ
bam-7218	212	13	deletion	deletion	NOUN
bam-7218	212	14	of	of	ADP
bam-7218	212	15	sh3bp2	sh3bp2	NOUN
bam-7218	212	16	.	.	PUNCT
bam-7218	213	1	protein	protein	NOUN
bam-7218	213	2	complex	complex	ADJ
bam-7218	213	3	purification	purification	NOUN
bam-7218	213	4	experiments	experiment	NOUN
bam-7218	213	5	combined	combine	VERB
bam-7218	213	6	with	with	ADP
bam-7218	213	7	mass	mass	ADJ
bam-7218	213	8	spectrometry	spectrometry	NOUN
bam-7218	213	9	analysis	analysis	NOUN
bam-7218	213	10	revealed	reveal	VERB
bam-7218	213	11	that	that	SCONJ
bam-7218	213	12	sh3bp2	sh3bp2	NOUN
bam-7218	213	13	interacts	interact	VERB
bam-7218	213	14	with	with	ADP
bam-7218	213	15	several	several	ADJ
bam-7218	213	16	postsynaptic	postsynaptic	ADJ
bam-7218	213	17	proteins	protein	NOUN
bam-7218	213	18	including	include	VERB
bam-7218	213	19	lrp4	lrp4	PROPN
bam-7218	213	20	,	,	PUNCT
bam-7218	213	21	achr	achr	PROPN
bam-7218	213	22	,	,	PUNCT
bam-7218	213	23	and	and	CCONJ
bam-7218	213	24	ck2	ck2	NOUN
bam-7218	213	25	,	,	PUNCT
bam-7218	213	26	proteins	protein	NOUN
bam-7218	213	27	of	of	ADP
bam-7218	213	28	the	the	DET
bam-7218	213	29	muscle	muscle	NOUN
bam-7218	213	30	contraction	contraction	NOUN
bam-7218	213	31	machinery	machinery	NOUN
bam-7218	213	32	as	as	ADV
bam-7218	213	33	well	well	ADV
bam-7218	213	34	as	as	ADP
bam-7218	213	35	several	several	ADJ
bam-7218	213	36	components	component	NOUN
bam-7218	213	37	of	of	ADP
bam-7218	213	38	the	the	DET
bam-7218	213	39	dgc	dgc	NOUN
bam-7218	213	40	.	.	PUNCT
bam-7218	214	1	our	our	PRON
bam-7218	214	2	results	result	NOUN
bam-7218	214	3	suggest	suggest	VERB
bam-7218	214	4	that	that	SCONJ
bam-7218	214	5	sh3bp2	sh3bp2	NOUN
bam-7218	214	6	acts	act	VERB
bam-7218	214	7	as	as	ADP
bam-7218	214	8	a	a	DET
bam-7218	214	9	scaffold	scaffold	NOUN
bam-7218	214	10	protein	protein	NOUN
bam-7218	214	11	involved	involve	VERB
bam-7218	214	12	in	in	ADP
bam-7218	214	13	the	the	DET
bam-7218	214	14	organization	organization	NOUN
bam-7218	214	15	of	of	ADP
bam-7218	214	16	the	the	DET
bam-7218	214	17	nmj	nmj	PROPN
bam-7218	214	18	postsynaptic	postsynaptic	ADJ
bam-7218	214	19	specialization	specialization	NOUN
bam-7218	214	20	.	.	PUNCT
bam-7218	215	1	supported	support	VERB
bam-7218	215	2	by	by	ADP
bam-7218	215	3	the	the	DET
bam-7218	215	4	national	national	PROPN
bam-7218	215	5	science	science	PROPN
bam-7218	215	6	centre	centre	NOUN
bam-7218	215	7	grants	grant	VERB
bam-7218	215	8	2012/05	2012/05	NUM
bam-7218	215	9	/	/	SYM
bam-7218	215	10	e	e	NOUN
bam-7218	215	11	/	/	SYM
bam-7218	215	12	nz3/00487	nz3/00487	PROPN
bam-7218	215	13	,	,	PUNCT
bam-7218	215	14	2013/09	2013/09	NUM
bam-7218	215	15	/	/	SYM
bam-7218	215	16	b	b	NOUN
bam-7218	215	17	/	/	SYM
bam-7218	215	18	nz3/03524	nz3/03524	PROPN
bam-7218	215	19	,	,	PUNCT
bam-7218	215	20	2015/19	2015/19	NUM
bam-7218	215	21	/	/	SYM
bam-7218	215	22	n/	n/	ADV
bam-7218	215	23	nz5/02268	nz5/02268	PRON
bam-7218	215	24	and	and	CCONJ
bam-7218	215	25	2016/21	2016/21	NUM
bam-7218	215	26	/	/	SYM
bam-7218	215	27	b	b	PROPN
bam-7218	215	28	/	/	SYM
bam-7218	215	29	nz3/03638	nz3/03638	PROPN
bam-7218	215	30	.	.	NOUN
bam-7218	215	31	1.2	1.2	NUM
bam-7218	215	32	identification	identification	NOUN
bam-7218	215	33	of	of	ADP
bam-7218	215	34	a	a	DET
bam-7218	215	35	novel	novel	ADJ
bam-7218	215	36	foxo	foxo	NOUN
bam-7218	215	37	-	-	PUNCT
bam-7218	215	38	dependent	dependent	ADJ
bam-7218	215	39	regulator	regulator	NOUN
bam-7218	215	40	of	of	ADP
bam-7218	215	41	muscle	muscle	NOUN
bam-7218	215	42	mass	mass	PROPN
bam-7218	215	43	anaïs	anaïs	PROPN
bam-7218	215	44	franco	franco	PROPN
bam-7218	215	45	-	-	PUNCT
bam-7218	215	46	romero	romero	PROPN
bam-7218	215	47	(	(	PUNCT
bam-7218	215	48	a	a	DET
bam-7218	215	49	,	,	PUNCT
bam-7218	215	50	b	b	NOUN
bam-7218	215	51	)	)	PUNCT
bam-7218	215	52	,	,	PUNCT
bam-7218	215	53	giulia	giulia	PROPN
bam-7218	215	54	milan	milan	PROPN
bam-7218	215	55	(	(	PUNCT
bam-7218	215	56	c	c	NOUN
bam-7218	215	57	)	)	PUNCT
bam-7218	215	58	,	,	PUNCT
bam-7218	216	1	vanina	vanina	PROPN
bam-7218	216	2	romanello	romanello	ADV
bam-7218	216	3	(	(	PUNCT
bam-7218	216	4	a	a	DET
bam-7218	216	5	,	,	PUNCT
bam-7218	216	6	b	b	NOUN
bam-7218	216	7	)	)	PUNCT
bam-7218	216	8	,	,	PUNCT
bam-7218	216	9	roberta	roberta	PROPN
bam-7218	216	10	sartori	sartori	PROPN
bam-7218	216	11	(	(	PUNCT
bam-7218	216	12	a	a	DET
bam-7218	216	13	,	,	PUNCT
bam-7218	216	14	b	b	NOUN
bam-7218	216	15	)	)	PUNCT
bam-7218	216	16	,	,	PUNCT
bam-7218	216	17	marco	marco	PROPN
bam-7218	216	18	sandri	sandri	PROPN
bam-7218	216	19	(	(	PUNCT
bam-7218	216	20	a	a	DET
bam-7218	216	21	,	,	PUNCT
bam-7218	216	22	b	b	NOUN
bam-7218	216	23	)	)	PUNCT
bam-7218	216	24	(	(	PUNCT
bam-7218	216	25	a	a	X
bam-7218	216	26	)	)	PUNCT
bam-7218	216	27	dept	dept	NOUN
bam-7218	216	28	of	of	ADP
bam-7218	216	29	biomedical	biomedical	ADJ
bam-7218	216	30	sciences	sciences	PROPN
bam-7218	216	31	,	,	PUNCT
bam-7218	216	32	university	university	NOUN
bam-7218	216	33	of	of	ADP
bam-7218	216	34	padova	padova	PROPN
bam-7218	216	35	,	,	PUNCT
bam-7218	216	36	italy	italy	PROPN
bam-7218	216	37	;	;	PUNCT
bam-7218	216	38	(	(	PUNCT
bam-7218	216	39	b	b	X
bam-7218	216	40	)	)	PUNCT
bam-7218	216	41	venetian	venetian	ADJ
bam-7218	216	42	institute	institute	NOUN
bam-7218	216	43	of	of	ADP
bam-7218	216	44	molecular	molecular	ADJ
bam-7218	216	45	medicine	medicine	NOUN
bam-7218	216	46	,	,	PUNCT
bam-7218	216	47	padova	padova	PROPN
bam-7218	216	48	,	,	PUNCT
bam-7218	216	49	italy	italy	PROPN
bam-7218	216	50	;	;	PUNCT
bam-7218	216	51	(	(	PUNCT
bam-7218	216	52	c	c	X
bam-7218	216	53	)	)	PUNCT
bam-7218	216	54	biozentrum	biozentrum	NOUN
bam-7218	216	55	,	,	PUNCT
bam-7218	216	56	university	university	PROPN
bam-7218	216	57	of	of	ADP
bam-7218	216	58	basel	basel	PROPN
bam-7218	216	59	,	,	PUNCT
bam-7218	216	60	basel	basel	PROPN
bam-7218	216	61	,	,	PUNCT
bam-7218	216	62	switzerland	switzerland	PROPN
bam-7218	216	63	.	.	PUNCT
bam-7218	217	1	e	e	X
bam-7218	217	2	-	-	NOUN
bam-7218	217	3	mail	mail	NOUN
bam-7218	217	4	:	:	PUNCT
bam-7218	217	5	anaisfr7@gmail.com	anaisfr7@gmail.com	X
bam-7218	217	6	muscle	muscle	NOUN
bam-7218	217	7	atrophy	atrophy	NOUN
bam-7218	217	8	results	result	NOUN
bam-7218	217	9	from	from	ADP
bam-7218	217	10	transcriptional	transcriptional	ADJ
bam-7218	217	11	adaptations	adaptation	NOUN
bam-7218	217	12	occurring	occur	VERB
bam-7218	217	13	in	in	ADP
bam-7218	217	14	catabolic	catabolic	ADJ
bam-7218	217	15	conditions	condition	NOUN
bam-7218	217	16	.	.	PUNCT
bam-7218	218	1	the	the	DET
bam-7218	218	2	forkhead	forkhead	PROPN
bam-7218	218	3	box	box	PROPN
bam-7218	218	4	(	(	PUNCT
bam-7218	218	5	fox	fox	NOUN
bam-7218	218	6	)	)	PUNCT
bam-7218	218	7	transcription	transcription	NOUN
bam-7218	218	8	factors	factor	NOUN
bam-7218	218	9	foxo1	foxo1	NOUN
bam-7218	218	10	,	,	PUNCT
bam-7218	218	11	foxo3	foxo3	PROPN
bam-7218	218	12	and	and	CCONJ
bam-7218	218	13	foxo4	foxo4	PROPN
bam-7218	218	14	are	be	AUX
bam-7218	218	15	critical	critical	ADJ
bam-7218	218	16	mediators	mediator	NOUN
bam-7218	218	17	of	of	ADP
bam-7218	218	18	the	the	DET
bam-7218	218	19	catabolic	catabolic	ADJ
bam-7218	218	20	response	response	NOUN
bam-7218	218	21	in	in	ADP
bam-7218	218	22	skeletal	skeletal	ADJ
bam-7218	218	23	muscle	muscle	NOUN
bam-7218	218	24	.	.	PUNCT
bam-7218	219	1	an	an	DET
bam-7218	219	2	exacerbated	exacerbate	VERB
bam-7218	219	3	activation	activation	NOUN
bam-7218	219	4	of	of	ADP
bam-7218	219	5	foxo	foxo	ADJ
bam-7218	219	6	family	family	NOUN
bam-7218	219	7	members	member	NOUN
bam-7218	219	8	leads	lead	VERB
bam-7218	219	9	to	to	ADP
bam-7218	219	10	increased	increase	VERB
bam-7218	219	11	protein	protein	NOUN
bam-7218	219	12	breakdown	breakdown	NOUN
bam-7218	219	13	and	and	CCONJ
bam-7218	219	14	muscle	muscle	NOUN
bam-7218	219	15	wasting	waste	VERB
bam-7218	219	16	.	.	PUNCT
bam-7218	220	1	microarray	microarray	VERB
bam-7218	220	2	analysis	analysis	NOUN
bam-7218	220	3	during	during	ADP
bam-7218	220	4	fasting	fasting	NOUN
bam-7218	220	5	showed	show	VERB
bam-7218	220	6	that	that	SCONJ
bam-7218	220	7	foxos	foxos	NOUN
bam-7218	220	8	are	be	AUX
bam-7218	220	9	required	require	VERB
bam-7218	220	10	for	for	ADP
bam-7218	220	11	the	the	DET
bam-7218	220	12	induction	induction	NOUN
bam-7218	220	13	of	of	ADP
bam-7218	220	14	several	several	ADJ
bam-7218	220	15	atrophy	atrophy	NOUN
bam-7218	220	16	-	-	PUNCT
bam-7218	220	17	related	relate	VERB
bam-7218	220	18	genes	gene	NOUN
bam-7218	220	19	(	(	PUNCT
bam-7218	220	20	atrogenes	atrogene	NOUN
bam-7218	220	21	)	)	PUNCT
bam-7218	220	22	.	.	PUNCT
bam-7218	221	1	however	however	ADV
bam-7218	221	2	,	,	PUNCT
bam-7218	221	3	the	the	DET
bam-7218	221	4	activation	activation	NOUN
bam-7218	221	5	of	of	ADP
bam-7218	221	6	already	already	ADV
bam-7218	221	7	identified	identify	VERB
bam-7218	221	8	atrogenes	atrogene	NOUN
bam-7218	221	9	can	can	AUX
bam-7218	221	10	not	not	PART
bam-7218	221	11	sustain	sustain	VERB
bam-7218	221	12	all	all	DET
bam-7218	221	13	the	the	DET
bam-7218	221	14	protein	protein	NOUN
bam-7218	221	15	breakdown	breakdown	NOUN
bam-7218	221	16	during	during	ADP
bam-7218	221	17	atrophy	atrophy	NOUN
bam-7218	221	18	.	.	PUNCT
bam-7218	222	1	indeed	indeed	ADV
bam-7218	222	2	,	,	PUNCT
bam-7218	222	3	the	the	DET
bam-7218	222	4	discovery	discovery	NOUN
bam-7218	222	5	of	of	ADP
bam-7218	222	6	new	new	ADJ
bam-7218	222	7	unknown	unknown	ADJ
bam-7218	222	8	players	player	NOUN
bam-7218	222	9	involved	involve	VERB
bam-7218	222	10	in	in	ADP
bam-7218	222	11	muscle	muscle	NOUN
bam-7218	222	12	protein	protein	NOUN
bam-7218	222	13	degradation	degradation	NOUN
bam-7218	222	14	is	be	AUX
bam-7218	222	15	now	now	ADV
bam-7218	222	16	of	of	ADP
bam-7218	222	17	potential	potential	ADJ
bam-7218	222	18	interest	interest	NOUN
bam-7218	222	19	.	.	PUNCT
bam-7218	223	1	we	we	PRON
bam-7218	223	2	identified	identify	VERB
bam-7218	223	3	several	several	ADJ
bam-7218	223	4	new	new	ADJ
bam-7218	223	5	foxos	foxos	NOUN
bam-7218	223	6	-	-	PUNCT
bam-7218	223	7	dependent	dependent	ADJ
bam-7218	223	8	genes	gene	NOUN
bam-7218	223	9	,	,	PUNCT
bam-7218	223	10	called	call	VERB
bam-7218	223	11	rikens	riken	NOUN
bam-7218	223	12	,	,	PUNCT
bam-7218	223	13	whose	whose	DET
bam-7218	223	14	functions	function	NOUN
bam-7218	223	15	are	be	AUX
bam-7218	223	16	still	still	ADV
bam-7218	223	17	unrevealed	unreveale	VERB
bam-7218	223	18	.	.	PUNCT
bam-7218	224	1	we	we	PRON
bam-7218	224	2	showed	show	VERB
bam-7218	224	3	that	that	SCONJ
bam-7218	224	4	some	some	DET
bam-7218	224	5	rikens	riken	NOUN
bam-7218	224	6	are	be	AUX
bam-7218	224	7	up	up	ADV
bam-7218	224	8	-	-	PUNCT
bam-7218	224	9	regulated	regulate	VERB
bam-7218	224	10	in	in	ADP
bam-7218	224	11	catabolic	catabolic	ADJ
bam-7218	224	12	condition	condition	NOUN
bam-7218	224	13	such	such	ADJ
bam-7218	224	14	as	as	ADP
bam-7218	224	15	fasting	fasting	NOUN
bam-7218	224	16	,	,	PUNCT
bam-7218	224	17	disuse	disuse	NOUN
bam-7218	224	18	and	and	CCONJ
bam-7218	224	19	cancer	cancer	NOUN
bam-7218	224	20	cachexia	cachexia	NOUN
bam-7218	224	21	.	.	PUNCT
bam-7218	225	1	interestingly	interestingly	ADV
bam-7218	225	2	,	,	PUNCT
bam-7218	225	3	knocking	knock	VERB
bam-7218	225	4	-	-	PUNCT
bam-7218	225	5	down	down	ADP
bam-7218	225	6	one	one	NUM
bam-7218	225	7	of	of	ADP
bam-7218	225	8	the	the	DET
bam-7218	225	9	rikens	riken	NOUN
bam-7218	225	10	(	(	PUNCT
bam-7218	225	11	riken1	riken1	X
bam-7218	225	12	)	)	PUNCT
bam-7218	225	13	protected	protect	VERB
bam-7218	225	14	from	from	ADP
bam-7218	225	15	atrophy	atrophy	NOUN
bam-7218	225	16	during	during	ADP
bam-7218	225	17	fasting	fast	VERB
bam-7218	225	18	.	.	PUNCT
bam-7218	226	1	moreover	moreover	ADV
bam-7218	226	2	,	,	PUNCT
bam-7218	226	3	colocalization	colocalization	NOUN
bam-7218	226	4	experiments	experiment	NOUN
bam-7218	226	5	showed	show	VERB
bam-7218	226	6	a	a	DET
bam-7218	226	7	possible	possible	ADJ
bam-7218	226	8	riken1	riken1	PROPN
bam-7218	226	9	-	-	PUNCT
bam-7218	226	10	lc3	lc3	NOUN
bam-7218	226	11	/	/	SYM
bam-7218	226	12	riken1	riken1	NOUN
bam-7218	226	13	-	-	PUNCT
bam-7218	226	14	lamp1	lamp1	NOUN
bam-7218	226	15	interaction	interaction	NOUN
bam-7218	226	16	,	,	PUNCT
bam-7218	226	17	suggesting	suggest	VERB
bam-7218	226	18	a	a	DET
bam-7218	226	19	potential	potential	ADJ
bam-7218	226	20	role	role	NOUN
bam-7218	226	21	in	in	ADP
bam-7218	226	22	the	the	DET
bam-7218	226	23	autophagy	autophagy	ADJ
bam-7218	226	24	-	-	PUNCT
bam-7218	226	25	lysosome	lysosome	NOUN
bam-7218	226	26	pathway	pathway	NOUN
bam-7218	226	27	.	.	PUNCT
bam-7218	227	1	our	our	PRON
bam-7218	227	2	findings	finding	NOUN
bam-7218	227	3	will	will	AUX
bam-7218	227	4	contribute	contribute	VERB
bam-7218	227	5	to	to	ADP
bam-7218	227	6	the	the	DET
bam-7218	227	7	identification	identification	NOUN
bam-7218	227	8	of	of	ADP
bam-7218	227	9	new	new	ADJ
bam-7218	227	10	mediators	mediator	NOUN
bam-7218	227	11	of	of	ADP
bam-7218	227	12	muscle	muscle	NOUN
bam-7218	227	13	mass	mass	NOUN
bam-7218	227	14	loss	loss	NOUN
bam-7218	227	15	in	in	ADP
bam-7218	227	16	order	order	NOUN
bam-7218	227	17	to	to	PART
bam-7218	227	18	develop	develop	VERB
bam-7218	227	19	new	new	ADJ
bam-7218	227	20	therapeutic	therapeutic	ADJ
bam-7218	227	21	approaches	approach	NOUN
bam-7218	227	22	against	against	ADP
bam-7218	227	23	muscle	muscle	NOUN
bam-7218	227	24	wasting	waste	VERB
bam-7218	227	25	.	.	PUNCT
bam-7218	228	1	1.3	1.3	NUM
bam-7218	228	2	the	the	DET
bam-7218	228	3	physiopathological	physiopathological	ADJ
bam-7218	228	4	role	role	NOUN
bam-7218	228	5	of	of	ADP
bam-7218	228	6	mitochondrial	mitochondrial	ADJ
bam-7218	228	7	calcium	calcium	NOUN
bam-7218	228	8	uptake	uptake	NOUN
bam-7218	228	9	in	in	ADP
bam-7218	228	10	skeletal	skeletal	ADJ
bam-7218	228	11	muscle	muscle	NOUN
bam-7218	228	12	homeostasis	homeostasis	NOUN
bam-7218	228	13	gaia	gaia	NOUN
bam-7218	228	14	gherardi	gherardi	PROPN
bam-7218	228	15	,	,	PUNCT
bam-7218	228	16	diego	diego	PROPN
bam-7218	228	17	de	de	PROPN
bam-7218	228	18	stefani	stefani	PROPN
bam-7218	228	19	,	,	PUNCT
bam-7218	228	20	rosario	rosario	PROPN
bam-7218	228	21	rizzuto	rizzuto	PROPN
bam-7218	228	22	,	,	PUNCT
bam-7218	228	23	cristina	cristina	PROPN
bam-7218	228	24	mammucari	mammucari	PROPN
bam-7218	228	25	dept	dept	PROPN
bam-7218	228	26	of	of	ADP
bam-7218	228	27	biomedical	biomedical	ADJ
bam-7218	228	28	sciences	sciences	PROPN
bam-7218	228	29	,	,	PUNCT
bam-7218	228	30	university	university	NOUN
bam-7218	228	31	of	of	ADP
bam-7218	228	32	padova	padova	PROPN
bam-7218	228	33	,	,	PUNCT
bam-7218	228	34	italy	italy	PROPN
bam-7218	228	35	.	.	PUNCT
bam-7218	229	1	e	e	X
bam-7218	229	2	-	-	NOUN
bam-7218	229	3	mail	mail	NOUN
bam-7218	229	4	:	:	PUNCT
bam-7218	229	5	gaia.gherardi88@gmail.com	gaia.gherardi88@gmail.com	X
bam-7218	229	6	muscle	muscle	NOUN
bam-7218	229	7	activity	activity	NOUN
bam-7218	229	8	leads	lead	VERB
bam-7218	229	9	to	to	ADP
bam-7218	229	10	major	major	ADJ
bam-7218	229	11	swings	swing	NOUN
bam-7218	229	12	in	in	ADP
bam-7218	229	13	mitochondrial	mitochondrial	ADJ
bam-7218	229	14	[	[	X
bam-7218	229	15	ca2	ca2	PROPN
bam-7218	229	16	+	+	PROPN
bam-7218	229	17	]	]	X
bam-7218	229	18	,	,	PUNCT
bam-7218	229	19	which	which	PRON
bam-7218	229	20	control	control	VERB
bam-7218	229	21	aerobic	aerobic	ADJ
bam-7218	229	22	metabolism	metabolism	NOUN
bam-7218	229	23	,	,	PUNCT
bam-7218	229	24	survival	survival	NOUN
bam-7218	229	25	pathways	pathway	NOUN
bam-7218	229	26	and	and	CCONJ
bam-7218	229	27	cell	cell	NOUN
bam-7218	229	28	death	death	NOUN
bam-7218	229	29	.	.	PUNCT
bam-7218	230	1	recently	recently	ADV
bam-7218	230	2	,	,	PUNCT
bam-7218	230	3	we	we	PRON
bam-7218	230	4	showed	show	VERB
bam-7218	230	5	that	that	SCONJ
bam-7218	230	6	mitochondrial	mitochondrial	ADJ
bam-7218	230	7	ca2	ca2	PROPN
bam-7218	230	8	+	+	PROPN
bam-7218	230	9	uptake	uptake	ADJ
bam-7218	230	10	positively	positively	ADV
bam-7218	230	11	modulates	modulate	VERB
bam-7218	230	12	skeletal	skeletal	ADJ
bam-7218	230	13	muscle	muscle	NOUN
bam-7218	230	14	trophism	trophism	NOUN
bam-7218	230	15	by	by	ADP
bam-7218	230	16	impinging	impinge	VERB
bam-7218	230	17	on	on	ADP
bam-7218	230	18	two	two	NUM
bam-7218	230	19	major	major	ADJ
bam-7218	230	20	pathways	pathway	NOUN
bam-7218	230	21	,	,	PUNCT
bam-7218	230	22	pgc-1alpha4	pgc-1alpha4	NOUN
bam-7218	230	23	and	and	CCONJ
bam-7218	230	24	igf1	igf1	PROPN
bam-7218	230	25	-	-	PUNCT
bam-7218	230	26	akt	akt	PROPN
bam-7218	230	27	/	/	SYM
bam-7218	230	28	pkb	pkb	PROPN
bam-7218	230	29	thanks	thank	NOUN
bam-7218	230	30	to	to	ADP
bam-7218	230	31	the	the	DET
bam-7218	230	32	use	use	NOUN
bam-7218	230	33	of	of	ADP
bam-7218	230	34	aav	aav	NOUN
bam-7218	230	35	vectors	vector	NOUN
bam-7218	230	36	.	.	PUNCT
bam-7218	231	1	here	here	ADV
bam-7218	231	2	,	,	PUNCT
bam-7218	231	3	we	we	PRON
bam-7218	231	4	aimed	aim	VERB
bam-7218	231	5	to	to	PART
bam-7218	231	6	discern	discern	VERB
bam-7218	231	7	the	the	DET
bam-7218	231	8	metabolic	metabolic	NOUN
bam-7218	231	9	route	route	NOUN
bam-7218	231	10	regulated	regulate	VERB
bam-7218	231	11	by	by	ADP
bam-7218	231	12	mitochondrial	mitochondrial	ADJ
bam-7218	231	13	ca2	ca2	PROPN
bam-7218	231	14	+	+	PROPN
bam-7218	231	15	uptake	uptake	NOUN
bam-7218	231	16	that	that	PRON
bam-7218	231	17	is	be	AUX
bam-7218	231	18	responsible	responsible	ADJ
bam-7218	231	19	for	for	ADP
bam-7218	231	20	muscle	muscle	NOUN
bam-7218	231	21	trophism	trophism	NOUN
bam-7218	231	22	.	.	PUNCT
bam-7218	232	1	for	for	ADP
bam-7218	232	2	this	this	DET
bam-7218	232	3	purpose	purpose	NOUN
bam-7218	232	4	,	,	PUNCT
bam-7218	232	5	we	we	PRON
bam-7218	232	6	generated	generate	VERB
bam-7218	232	7	a	a	DET
bam-7218	232	8	skeletal	skeletal	ADJ
bam-7218	232	9	muscle	muscle	NOUN
bam-7218	232	10	specific	specific	ADJ
bam-7218	232	11	mcu	mcu	PROPN
bam-7218	232	12	knockout	knockout	PROPN
bam-7218	232	13	mouse	mouse	PROPN
bam-7218	232	14	(	(	PUNCT
bam-7218	232	15	mlc1f	mlc1f	PROPN
bam-7218	232	16	-	-	PUNCT
bam-7218	232	17	cre	cre	NOUN
bam-7218	232	18	-	-	PUNCT
bam-7218	232	19	mcu-/-	mcu-/-	NOUN
bam-7218	232	20	)	)	PUNCT
bam-7218	232	21	,	,	PUNCT
bam-7218	232	22	by	by	ADP
bam-7218	232	23	crossing	cross	VERB
bam-7218	232	24	a	a	DET
bam-7218	232	25	mcufl	mcufl	ADJ
bam-7218	232	26	/	/	SYM
bam-7218	232	27	fl	fl	PROPN
bam-7218	232	28	mouse	mouse	NOUN
bam-7218	232	29	with	with	ADP
bam-7218	232	30	a	a	DET
bam-7218	232	31	line	line	NOUN
bam-7218	232	32	expressing	express	VERB
bam-7218	232	33	the	the	DET
bam-7218	232	34	cre	cre	PROPN
bam-7218	232	35	recombinase	recombinase	NOUN
bam-7218	232	36	under	under	ADP
bam-7218	232	37	the	the	DET
bam-7218	232	38	control	control	NOUN
bam-7218	232	39	of	of	ADP
bam-7218	232	40	the	the	DET
bam-7218	232	41	myosin	myosin	NOUN
bam-7218	232	42	light	light	PROPN
bam-7218	232	43	chain	chain	PROPN
bam-7218	232	44	1f	1f	PROPN
bam-7218	232	45	(	(	PUNCT
bam-7218	232	46	mlc1f	mlc1f	PROPN
bam-7218	232	47	)	)	PUNCT
bam-7218	232	48	promoter	promoter	NOUN
bam-7218	232	49	.	.	PUNCT
bam-7218	233	1	our	our	PRON
bam-7218	233	2	preliminary	preliminary	ADJ
bam-7218	233	3	data	datum	NOUN
bam-7218	233	4	confirm	confirm	VERB
bam-7218	233	5	that	that	PRON
bam-7218	233	6	pgc-1alpha4	pgc-1alpha4	NOUN
bam-7218	233	7	and	and	CCONJ
bam-7218	233	8	igf1	igf1	PROPN
bam-7218	233	9	-	-	PUNCT
bam-7218	233	10	akt	akt	PROPN
bam-7218	233	11	/	/	SYM
bam-7218	233	12	pkb	pkb	PROPN
bam-7218	233	13	signaling	signal	VERB
bam-7218	233	14	pathways	pathway	NOUN
bam-7218	233	15	are	be	AUX
bam-7218	233	16	negatively	negatively	ADV
bam-7218	233	17	regulated	regulate	VERB
bam-7218	233	18	in	in	ADP
bam-7218	233	19	skeletal	skeletal	ADJ
bam-7218	233	20	muscle	muscle	NOUN
bam-7218	233	21	specific	specific	ADJ
bam-7218	233	22	mcu	mcu	NOUN
bam-7218	233	23	knockout	knockout	NOUN
bam-7218	233	24	animals	animal	NOUN
bam-7218	233	25	.	.	PUNCT
bam-7218	234	1	in	in	ADP
bam-7218	234	2	addition	addition	NOUN
bam-7218	234	3	,	,	PUNCT
bam-7218	234	4	we	we	PRON
bam-7218	234	5	also	also	ADV
bam-7218	234	6	observed	observe	VERB
bam-7218	234	7	a	a	DET
bam-7218	234	8	slight	slight	ADJ
bam-7218	234	9	decrease	decrease	NOUN
bam-7218	234	10	of	of	ADP
bam-7218	234	11	fibre	fibre	NOUN
bam-7218	234	12	size	size	NOUN
bam-7218	234	13	in	in	ADP
bam-7218	234	14	mlc1f	mlc1f	PROPN
bam-7218	234	15	-	-	PUNCT
bam-7218	234	16	cre	cre	PROPN
bam-7218	234	17	-	-	PUNCT
bam-7218	234	18	mcu-/skeletal	mcu-/skeletal	ADJ
bam-7218	234	19	muscles	muscle	NOUN
bam-7218	234	20	.	.	PUNCT
bam-7218	235	1	most	most	ADV
bam-7218	235	2	importantly	importantly	ADV
bam-7218	235	3	,	,	PUNCT
bam-7218	235	4	when	when	SCONJ
bam-7218	235	5	these	these	DET
bam-7218	235	6	mice	mouse	NOUN
bam-7218	235	7	were	be	AUX
bam-7218	235	8	exercised	exercise	VERB
bam-7218	235	9	on	on	ADP
bam-7218	235	10	a	a	DET
bam-7218	235	11	treadmill	treadmill	NOUN
bam-7218	235	12	using	use	VERB
bam-7218	235	13	different	different	ADJ
bam-7218	235	14	training	training	NOUN
bam-7218	235	15	protocols	protocol	NOUN
bam-7218	235	16	,	,	PUNCT
bam-7218	235	17	an	an	DET
bam-7218	235	18	impaired	impaired	ADJ
bam-7218	235	19	running	running	NOUN
bam-7218	235	20	capacity	capacity	NOUN
bam-7218	235	21	became	become	VERB
bam-7218	235	22	evident	evident	ADJ
bam-7218	235	23	,	,	PUNCT
bam-7218	235	24	indicating	indicate	VERB
bam-7218	235	25	that	that	SCONJ
bam-7218	235	26	mitochondrial	mitochondrial	ADJ
bam-7218	235	27	ca2	ca2	PROPN
bam-7218	235	28	+	+	PROPN
bam-7218	235	29	accumulation	accumulation	NOUN
bam-7218	235	30	is	be	AUX
bam-7218	235	31	required	require	VERB
bam-7218	235	32	to	to	PART
bam-7218	235	33	guarantee	guarantee	VERB
bam-7218	235	34	skeletal	skeletal	ADJ
bam-7218	235	35	muscle	muscle	NOUN
bam-7218	235	36	performance	performance	NOUN
bam-7218	235	37	.	.	PUNCT
bam-7218	236	1	finally	finally	ADV
bam-7218	236	2	,	,	PUNCT
bam-7218	236	3	a	a	DET
bam-7218	236	4	clear	clear	ADJ
bam-7218	236	5	metabolic	metabolic	NOUN
bam-7218	236	6	alteration	alteration	NOUN
bam-7218	236	7	is	be	AUX
bam-7218	236	8	present	present	ADJ
bam-7218	236	9	in	in	ADP
bam-7218	236	10	mlc1fcre	mlc1fcre	PROPN
bam-7218	236	11	-	-	PUNCT
bam-7218	236	12	mcu-/animals	mcu-/animal	NOUN
bam-7218	236	13	.	.	PUNCT
bam-7218	237	1	specifically	specifically	ADV
bam-7218	237	2	,	,	PUNCT
bam-7218	237	3	mlc1f	mlc1f	PROPN
bam-7218	237	4	-	-	PUNCT
bam-7218	237	5	cre	cre	PROPN
bam-7218	237	6	-	-	PUNCT
bam-7218	237	7	mcu-/	mcu-/	NOUN
bam-7218	237	8	mice	mouse	NOUN
bam-7218	237	9	show	show	NOUN
bam-7218	237	10	decreased	decrease	VERB
bam-7218	237	11	glucose	glucose	NOUN
bam-7218	237	12	,	,	PUNCT
bam-7218	237	13	increased	increase	VERB
bam-7218	237	14	lactate	lactate	NOUN
bam-7218	237	15	,	,	PUNCT
bam-7218	237	16	free	free	ADJ
bam-7218	237	17	fatty	fatty	NOUN
bam-7218	237	18	acids	acid	NOUN
bam-7218	237	19	and	and	CCONJ
bam-7218	237	20	ketone	ketone	NOUN
bam-7218	237	21	bodies	body	NOUN
bam-7218	237	22	,	,	PUNCT
bam-7218	237	23	suggesting	suggest	VERB
bam-7218	237	24	an	an	DET
bam-7218	237	25	impaired	impaired	ADJ
bam-7218	237	26	crosstalk	crosstalk	NOUN
bam-7218	237	27	between	between	ADP
bam-7218	237	28	skeletal	skeletal	ADJ
bam-7218	237	29	muscle	muscle	NOUN
bam-7218	237	30	and	and	CCONJ
bam-7218	237	31	liver	liver	NOUN
bam-7218	237	32	.	.	PUNCT
bam-7218	238	1	taken	take	VERB
bam-7218	238	2	together	together	ADV
bam-7218	238	3	,	,	PUNCT
bam-7218	238	4	these	these	DET
bam-7218	238	5	data	datum	NOUN
bam-7218	238	6	indicate	indicate	VERB
bam-7218	238	7	that	that	SCONJ
bam-7218	238	8	mitochondrial	mitochondrial	ADJ
bam-7218	238	9	ca2	ca2	PROPN
bam-7218	238	10	+	+	PROPN
bam-7218	238	11	uptake	uptake	NOUN
bam-7218	238	12	plays	play	VERB
bam-7218	238	13	a	a	DET
bam-7218	238	14	pivotal	pivotal	ADJ
bam-7218	238	15	role	role	NOUN
bam-7218	238	16	in	in	ADP
bam-7218	238	17	the	the	DET
bam-7218	238	18	control	control	NOUN
bam-7218	238	19	of	of	ADP
bam-7218	238	20	skeletal	skeletal	ADJ
bam-7218	238	21	muscle	muscle	NOUN
bam-7218	238	22	trophism	trophism	NOUN
bam-7218	238	23	.	.	PUNCT
bam-7218	239	1	further	further	ADJ
bam-7218	239	2	investigations	investigation	NOUN
bam-7218	239	3	of	of	ADP
bam-7218	239	4	mcudependent	mcudependent	ADJ
bam-7218	239	5	effects	effect	NOUN
bam-7218	239	6	on	on	ADP
bam-7218	239	7	skeletal	skeletal	ADJ
bam-7218	239	8	muscle	muscle	NOUN
bam-7218	239	9	homeostasis	homeostasis	NOUN
bam-7218	239	10	will	will	AUX
bam-7218	239	11	represent	represent	VERB
bam-7218	239	12	an	an	DET
bam-7218	239	13	important	important	ADJ
bam-7218	239	14	task	task	NOUN
bam-7218	239	15	for	for	ADP
bam-7218	239	16	the	the	DET
bam-7218	239	17	future	future	NOUN
bam-7218	239	18	.	.	PUNCT
bam-7218	240	1	indeed	indeed	ADV
bam-7218	240	2	,	,	PUNCT
bam-7218	240	3	this	this	DET
bam-7218	240	4	research	research	NOUN
bam-7218	240	5	will	will	AUX
bam-7218	240	6	provide	provide	VERB
bam-7218	240	7	new	new	ADJ
bam-7218	240	8	possible	possible	ADJ
bam-7218	240	9	targets	target	NOUN
bam-7218	240	10	for	for	ADP
bam-7218	240	11	clinical	clinical	ADJ
bam-7218	240	12	intervention	intervention	NOUN
bam-7218	240	13	in	in	ADP
bam-7218	240	14	all	all	DET
bam-7218	240	15	diseases	disease	NOUN
bam-7218	240	16	characterized	characterize	VERB
bam-7218	240	17	by	by	ADP
bam-7218	240	18	muscle	muscle	NOUN
bam-7218	240	19	loss	loss	NOUN
bam-7218	240	20	,	,	PUNCT
bam-7218	240	21	such	such	ADJ
bam-7218	240	22	as	as	ADP
bam-7218	240	23	dystrophies	dystrophy	NOUN
bam-7218	240	24	,	,	PUNCT
bam-7218	240	25	cancer	cancer	NOUN
bam-7218	240	26	cachexia	cachexia	NOUN
bam-7218	240	27	and	and	CCONJ
bam-7218	240	28	aging	aging	NOUN
bam-7218	240	29	.	.	PUNCT
bam-7218	241	1	1.4	1.4	NUM
bam-7218	241	2	mitochondria	mitochondria	NOUN
bam-7218	241	3	and	and	CCONJ
bam-7218	241	4	cytoskeleton	cytoskeleton	PROPN
bam-7218	241	5	rearrangement	rearrangement	NOUN
bam-7218	241	6	in	in	ADP
bam-7218	241	7	drp1	drp1	NOUN
bam-7218	241	8	overexpressing	overexpresse	VERB
bam-7218	241	9	skeletal	skeletal	ADJ
bam-7218	241	10	muscle	muscle	NOUN
bam-7218	241	11	matteo	matteo	PROPN
bam-7218	241	12	giovarelli	giovarelli	PROPN
bam-7218	241	13	(	(	PUNCT
bam-7218	241	14	a	a	NOUN
bam-7218	241	15	)	)	PUNCT
bam-7218	241	16	,	,	PUNCT
bam-7218	241	17	silvia	silvia	PROPN
bam-7218	241	18	zecchini	zecchini	PROPN
bam-7218	241	19	(	(	PUNCT
bam-7218	241	20	b	b	NOUN
bam-7218	241	21	)	)	PUNCT
bam-7218	241	22	,	,	PUNCT
bam-7218	241	23	martina	martina	PROPN
bam-7218	241	24	brucoli	brucoli	PROPN
bam-7218	241	25	(	(	PUNCT
bam-7218	241	26	b	b	NOUN
bam-7218	241	27	)	)	PUNCT
bam-7218	241	28	,	,	PUNCT
bam-7218	241	29	clara	clara	PROPN
bam-7218	241	30	de	de	PROPN
bam-7218	241	31	palma	palma	PROPN
bam-7218	241	32	(	(	PUNCT
bam-7218	241	33	b	b	NOUN
bam-7218	241	34	)	)	PUNCT
bam-7218	241	35	(	(	PUNCT
bam-7218	241	36	a	a	X
bam-7218	241	37	)	)	PUNCT
bam-7218	241	38	dept	dept	NOUN
bam-7218	241	39	of	of	ADP
bam-7218	241	40	biomedical	biomedical	ADJ
bam-7218	241	41	and	and	CCONJ
bam-7218	241	42	clinical	clinical	ADJ
bam-7218	241	43	sciences	science	NOUN
bam-7218	241	44	“	"	PUNCT
bam-7218	241	45	luigi	luigi	PROPN
bam-7218	241	46	sacco	sacco	PROPN
bam-7218	241	47	”	"	PUNCT
bam-7218	241	48	,	,	PUNCT
bam-7218	241	49	università	università	PROPN
bam-7218	241	50	degli	degli	PROPN
bam-7218	241	51	studi	studi	PROPN
bam-7218	241	52	di	di	X
bam-7218	241	53	milano	milano	PROPN
bam-7218	241	54	,	,	PUNCT
bam-7218	241	55	milano	milano	PROPN
bam-7218	241	56	,	,	PUNCT
bam-7218	241	57	italy	italy	PROPN
bam-7218	241	58	;	;	PUNCT
bam-7218	241	59	(	(	PUNCT
bam-7218	241	60	b	b	X
bam-7218	241	61	)	)	PUNCT
bam-7218	241	62	unit	unit	NOUN
bam-7218	241	63	of	of	ADP
bam-7218	241	64	clinical	clinical	ADJ
bam-7218	241	65	pharmacology	pharmacology	NOUN
bam-7218	241	66	,	,	PUNCT
bam-7218	241	67	university	university	NOUN
bam-7218	241	68	hospital	hospital	NOUN
bam-7218	241	69	“	"	PUNCT
bam-7218	241	70	luigi	luigi	PROPN
bam-7218	241	71	sacco”-asst	sacco”-asst	PROPN
bam-7218	241	72	fatebenefratelli	fatebenefratelli	PROPN
bam-7218	241	73	sacco	sacco	PROPN
bam-7218	241	74	;	;	PUNCT
bam-7218	241	75	national	national	PROPN
bam-7218	241	76	research	research	PROPN
bam-7218	241	77	council	council	PROPN
bam-7218	241	78	-	-	PUNCT
bam-7218	241	79	institute	institute	PROPN
bam-7218	241	80	of	of	ADP
bam-7218	241	81	neuroscience	neuroscience	NOUN
bam-7218	241	82	;	;	PUNCT
bam-7218	241	83	dept	dept	NOUN
bam-7218	241	84	of	of	ADP
bam-7218	241	85	biomedical	biomedical	ADJ
bam-7218	241	86	and	and	CCONJ
bam-7218	241	87	clinical	clinical	ADJ
bam-7218	241	88	sciences	science	NOUN
bam-7218	241	89	,	,	PUNCT
bam-7218	241	90	università	università	PROPN
bam-7218	241	91	degli	degli	PROPN
bam-7218	241	92	studi	studi	PROPN
bam-7218	241	93	di	di	X
bam-7218	241	94	milano	milano	PROPN
bam-7218	241	95	,	,	PUNCT
bam-7218	241	96	milano	milano	PROPN
bam-7218	241	97	,	,	PUNCT
bam-7218	241	98	italy	italy	PROPN
bam-7218	241	99	.	.	PUNCT
bam-7218	242	1	e	e	X
bam-7218	242	2	-	-	NOUN
bam-7218	242	3	mail	mail	NOUN
bam-7218	242	4	:	:	PUNCT
bam-7218	243	1	mgiovarelli@gmail.com	mgiovarelli@gmail.com	X
bam-7218	244	1	mailto:anaisfr7@gmail.com	mailto:anaisfr7@gmail.com	X
bam-7218	244	2	mailto:gaia.gherardi88@gmail.com	mailto:gaia.gherardi88@gmail.com	X
bam-7218	244	3	mailto:mgiovarelli@gmail.com	mailto:mgiovarelli@gmail.com	PROPN
bam-7218	244	4	14	14	NUM
bam-7218	244	5	th	th	NUM
bam-7218	244	6	iiim	iiim	NOUN
bam-7218	244	7	meeting	meeting	NOUN
bam-7218	244	8	,	,	PUNCT
bam-7218	244	9	assisi	assisi	PROPN
bam-7218	244	10	,	,	PUNCT
bam-7218	244	11	italy	italy	PROPN
bam-7218	244	12	october	october	PROPN
bam-7218	244	13	12	12	NUM
bam-7218	244	14	-	-	SYM
bam-7218	244	15	15	15	NUM
bam-7218	244	16	2017	2017	NUM
bam-7218	244	17	eur	eur	PROPN
bam-7218	244	18	j	j	PROPN
bam-7218	244	19	transl	transl	PROPN
bam-7218	244	20	myol	myol	ADV
bam-7218	244	21	27	27	NUM
bam-7218	244	22	(	(	PUNCT
bam-7218	244	23	4	4	NUM
bam-7218	244	24	):	):	SYM
bam-7218	244	25	185	185	NUM
bam-7218	244	26	-	-	SYM
bam-7218	244	27	224	224	NUM
bam-7218	244	28	191	191	NUM
bam-7218	244	29	in	in	ADP
bam-7218	244	30	skeletal	skeletal	ADJ
bam-7218	244	31	muscle	muscle	NOUN
bam-7218	244	32	mitochondrial	mitochondrial	ADJ
bam-7218	244	33	fusion	fusion	NOUN
bam-7218	244	34	and	and	CCONJ
bam-7218	244	35	fission	fission	NOUN
bam-7218	244	36	define	define	VERB
bam-7218	244	37	the	the	DET
bam-7218	244	38	mitochondrial	mitochondrial	ADJ
bam-7218	244	39	network	network	NOUN
bam-7218	244	40	morphology	morphology	NOUN
bam-7218	244	41	regulating	regulate	VERB
bam-7218	244	42	myofiber	myofiber	ADJ
bam-7218	244	43	differentiation	differentiation	NOUN
bam-7218	244	44	,	,	PUNCT
bam-7218	244	45	muscle	muscle	NOUN
bam-7218	244	46	contraction	contraction	NOUN
bam-7218	244	47	and	and	CCONJ
bam-7218	244	48	response	response	NOUN
bam-7218	244	49	to	to	ADP
bam-7218	244	50	stress	stress	NOUN
bam-7218	244	51	conditions	condition	NOUN
bam-7218	244	52	.	.	PUNCT
bam-7218	245	1	mitochondrial	mitochondrial	ADJ
bam-7218	245	2	fission	fission	NOUN
bam-7218	245	3	is	be	AUX
bam-7218	245	4	mainly	mainly	ADV
bam-7218	245	5	mediated	mediate	VERB
bam-7218	245	6	by	by	ADP
bam-7218	245	7	dynamin	dynamin	NOUN
bam-7218	245	8	-	-	PUNCT
bam-7218	245	9	related	relate	VERB
bam-7218	245	10	protein	protein	NOUN
bam-7218	245	11	1	1	NUM
bam-7218	245	12	(	(	PUNCT
bam-7218	245	13	drp1	drp1	PROPN
bam-7218	245	14	)	)	PUNCT
bam-7218	245	15	which	which	PRON
bam-7218	245	16	represents	represent	VERB
bam-7218	245	17	a	a	DET
bam-7218	245	18	critical	critical	ADJ
bam-7218	245	19	player	player	NOUN
bam-7218	245	20	in	in	ADP
bam-7218	245	21	myogenesis	myogenesis	NOUN
bam-7218	245	22	and	and	CCONJ
bam-7218	245	23	its	its	PRON
bam-7218	245	24	inhibition	inhibition	NOUN
bam-7218	245	25	suppresses	suppress	VERB
bam-7218	245	26	myotube	myotube	NOUN
bam-7218	245	27	formation	formation	NOUN
bam-7218	245	28	.	.	PUNCT
bam-7218	246	1	we	we	PRON
bam-7218	246	2	studied	study	VERB
bam-7218	246	3	a	a	DET
bam-7218	246	4	transgenic	transgenic	NOUN
bam-7218	246	5	mouse	mouse	NOUN
bam-7218	246	6	overexpressing	overexpresse	VERB
bam-7218	246	7	drp1	drp1	NOUN
bam-7218	246	8	specifically	specifically	ADV
bam-7218	246	9	in	in	ADP
bam-7218	246	10	skeletal	skeletal	ADJ
bam-7218	246	11	muscle	muscle	NOUN
bam-7218	246	12	(	(	PUNCT
bam-7218	246	13	drp	drp	PROPN
bam-7218	246	14	/	/	SYM
bam-7218	246	15	mc	mc	PROPN
bam-7218	246	16	)	)	PUNCT
bam-7218	246	17	.	.	PUNCT
bam-7218	247	1	we	we	PRON
bam-7218	247	2	have	have	AUX
bam-7218	247	3	already	already	ADV
bam-7218	247	4	showed	show	VERB
bam-7218	247	5	growth	growth	NOUN
bam-7218	247	6	defects	defect	NOUN
bam-7218	247	7	of	of	ADP
bam-7218	247	8	drp	drp	PROPN
bam-7218	247	9	/	/	SYM
bam-7218	247	10	mc	mc	PROPN
bam-7218	247	11	mice	mouse	NOUN
bam-7218	247	12	starting	start	VERB
bam-7218	247	13	from	from	ADP
bam-7218	247	14	p7	p7	NOUN
bam-7218	247	15	mainly	mainly	ADV
bam-7218	247	16	due	due	ADP
bam-7218	247	17	to	to	ADP
bam-7218	247	18	an	an	DET
bam-7218	247	19	impairment	impairment	NOUN
bam-7218	247	20	of	of	ADP
bam-7218	247	21	glycolytic	glycolytic	ADJ
bam-7218	247	22	muscles	muscle	NOUN
bam-7218	247	23	development	development	NOUN
bam-7218	247	24	;	;	PUNCT
bam-7218	247	25	they	they	PRON
bam-7218	247	26	display	display	VERB
bam-7218	247	27	an	an	DET
bam-7218	247	28	overall	overall	ADJ
bam-7218	247	29	20	20	NUM
bam-7218	247	30	%	%	NOUN
bam-7218	247	31	reduction	reduction	NOUN
bam-7218	247	32	of	of	ADP
bam-7218	247	33	body	body	NOUN
bam-7218	247	34	weight	weight	NOUN
bam-7218	247	35	at	at	ADP
bam-7218	247	36	p100	p100	PROPN
bam-7218	247	37	and	and	CCONJ
bam-7218	247	38	a	a	DET
bam-7218	247	39	drop	drop	NOUN
bam-7218	247	40	of	of	ADP
bam-7218	247	41	locomotor	locomotor	ADJ
bam-7218	247	42	performance	performance	NOUN
bam-7218	247	43	without	without	ADP
bam-7218	247	44	any	any	DET
bam-7218	247	45	increasing	increasing	NOUN
bam-7218	247	46	in	in	ADP
bam-7218	247	47	catabolic	catabolic	ADJ
bam-7218	247	48	event	event	NOUN
bam-7218	247	49	.	.	PUNCT
bam-7218	248	1	drp	drp	PROPN
bam-7218	248	2	/	/	SYM
bam-7218	248	3	mc	mc	PROPN
bam-7218	248	4	mice	mouse	NOUN
bam-7218	248	5	exhibit	exhibit	VERB
bam-7218	248	6	low	low	ADJ
bam-7218	248	7	mitochondrial	mitochondrial	ADJ
bam-7218	248	8	dna	dna	NOUN
bam-7218	248	9	levels	level	NOUN
bam-7218	248	10	which	which	PRON
bam-7218	248	11	trigger	trigger	VERB
bam-7218	248	12	mitochondrial	mitochondrial	ADJ
bam-7218	248	13	stress	stress	NOUN
bam-7218	248	14	and	and	CCONJ
bam-7218	248	15	upregulate	upregulate	VERB
bam-7218	248	16	the	the	DET
bam-7218	248	17	unfolding	unfold	VERB
bam-7218	248	18	proteins	protein	NOUN
bam-7218	248	19	response	response	NOUN
bam-7218	248	20	(	(	PUNCT
bam-7218	248	21	mtupr	mtupr	NOUN
bam-7218	248	22	)	)	PUNCT
bam-7218	248	23	together	together	ADV
bam-7218	248	24	with	with	ADP
bam-7218	248	25	an	an	DET
bam-7218	248	26	impairment	impairment	NOUN
bam-7218	248	27	of	of	ADP
bam-7218	248	28	growth	growth	NOUN
bam-7218	248	29	hormone	hormone	NOUN
bam-7218	248	30	anabolic	anabolic	NOUN
bam-7218	248	31	pathway	pathway	NOUN
bam-7218	248	32	.	.	PUNCT
bam-7218	249	1	interestingly	interestingly	ADV
bam-7218	249	2	we	we	PRON
bam-7218	249	3	observe	observe	VERB
bam-7218	249	4	a	a	DET
bam-7218	249	5	strong	strong	ADJ
bam-7218	249	6	remodeling	remodeling	NOUN
bam-7218	249	7	of	of	ADP
bam-7218	249	8	mitochondria	mitochondria	ADJ
bam-7218	249	9	distribution	distribution	NOUN
bam-7218	249	10	with	with	ADP
bam-7218	249	11	a	a	DET
bam-7218	249	12	depletion	depletion	NOUN
bam-7218	249	13	of	of	ADP
bam-7218	249	14	intermyofibrillar	intermyofibrillar	ADJ
bam-7218	249	15	mitochondria	mitochondria	NOUN
bam-7218	249	16	and	and	CCONJ
bam-7218	249	17	an	an	DET
bam-7218	249	18	enrichment	enrichment	NOUN
bam-7218	249	19	of	of	ADP
bam-7218	249	20	the	the	DET
bam-7218	249	21	subsarcolemma	subsarcolemma	ADJ
bam-7218	249	22	pool	pool	NOUN
bam-7218	249	23	.	.	PUNCT
bam-7218	250	1	in	in	ADP
bam-7218	250	2	parallel	parallel	NOUN
bam-7218	250	3	,	,	PUNCT
bam-7218	250	4	we	we	PRON
bam-7218	250	5	observe	observe	VERB
bam-7218	250	6	a	a	DET
bam-7218	250	7	perturbation	perturbation	NOUN
bam-7218	250	8	of	of	ADP
bam-7218	250	9	citoskeleton	citoskeleton	NOUN
bam-7218	250	10	framework	framework	NOUN
bam-7218	250	11	characterized	characterize	VERB
bam-7218	250	12	by	by	ADP
bam-7218	250	13	the	the	DET
bam-7218	250	14	disruption	disruption	NOUN
bam-7218	250	15	of	of	ADP
bam-7218	250	16	desmin	desmin	ADJ
bam-7218	250	17	network	network	NOUN
bam-7218	250	18	(	(	PUNCT
bam-7218	250	19	the	the	DET
bam-7218	250	20	main	main	ADJ
bam-7218	250	21	skeletal	skeletal	ADJ
bam-7218	250	22	muscle	muscle	NOUN
bam-7218	250	23	intermediate	intermediate	ADJ
bam-7218	250	24	filament	filament	NOUN
bam-7218	250	25	connecting	connect	VERB
bam-7218	250	26	mitochondria	mitochondria	NOUN
bam-7218	250	27	to	to	ADP
bam-7218	250	28	citoskeleton	citoskeleton	PROPN
bam-7218	250	29	)	)	PUNCT
bam-7218	250	30	with	with	ADP
bam-7218	250	31	the	the	DET
bam-7218	250	32	presence	presence	NOUN
bam-7218	250	33	of	of	ADP
bam-7218	250	34	desmin	desmin	ADJ
bam-7218	250	35	aggregates	aggregate	NOUN
bam-7218	250	36	inside	inside	ADP
bam-7218	250	37	myofibers	myofiber	NOUN
bam-7218	250	38	and	and	CCONJ
bam-7218	250	39	accumulation	accumulation	NOUN
bam-7218	250	40	beneath	beneath	ADP
bam-7218	250	41	the	the	DET
bam-7218	250	42	sarcolemma	sarcolemma	NOUN
bam-7218	250	43	.	.	PUNCT
bam-7218	251	1	our	our	PRON
bam-7218	251	2	study	study	NOUN
bam-7218	251	3	aims	aim	VERB
bam-7218	251	4	at	at	PART
bam-7218	251	5	identify	identify	VERB
bam-7218	251	6	the	the	DET
bam-7218	251	7	involvement	involvement	NOUN
bam-7218	251	8	of	of	ADP
bam-7218	251	9	different	different	ADJ
bam-7218	251	10	molecular	molecular	ADJ
bam-7218	251	11	effectors	effector	NOUN
bam-7218	251	12	,	,	PUNCT
bam-7218	251	13	such	such	ADJ
bam-7218	251	14	as	as	ADP
bam-7218	251	15	the	the	DET
bam-7218	251	16	kinesin	kinesin	PROPN
bam-7218	251	17	kif5b	kif5b	PROPN
bam-7218	251	18	and	and	CCONJ
bam-7218	251	19	myotubularin	myotubularin	NOUN
bam-7218	251	20	,	,	PUNCT
bam-7218	251	21	in	in	ADP
bam-7218	251	22	dysregulated	dysregulate	VERB
bam-7218	251	23	muscular	muscular	ADJ
bam-7218	251	24	and	and	CCONJ
bam-7218	251	25	mitochondrial	mitochondrial	ADJ
bam-7218	251	26	phenotype	phenotype	NOUN
bam-7218	251	27	of	of	ADP
bam-7218	251	28	drp	drp	PROPN
bam-7218	251	29	/	/	SYM
bam-7218	251	30	mc	mc	PROPN
bam-7218	251	31	mice	mouse	NOUN
bam-7218	251	32	.	.	PUNCT
bam-7218	252	1	1.5	1.5	NUM
bam-7218	252	2	unravelling	unravel	VERB
bam-7218	252	3	myo9a	myo9a	PROPN
bam-7218	252	4	pathophysiology	pathophysiology	NOUN
bam-7218	252	5	in	in	ADP
bam-7218	252	6	cms	cms	PROPN
bam-7218	252	7	emily	emily	PROPN
bam-7218	252	8	o’connor	o’connor	PROPN
bam-7218	252	9	(	(	PUNCT
bam-7218	252	10	a	a	X
bam-7218	252	11	)	)	PUNCT
bam-7218	252	12	,	,	PUNCT
bam-7218	252	13	vietxuan	vietxuan	NOUN
bam-7218	252	14	phan	phan	PROPN
bam-7218	252	15	(	(	PUNCT
bam-7218	252	16	b	b	NOUN
bam-7218	252	17	)	)	PUNCT
bam-7218	252	18	,	,	PUNCT
bam-7218	252	19	isabell	isabell	PROPN
bam-7218	252	20	cordts	cordts	PROPN
bam-7218	252	21	(	(	PUNCT
bam-7218	252	22	a	a	NOUN
bam-7218	252	23	)	)	PUNCT
bam-7218	252	24	,	,	PUNCT
bam-7218	252	25	george	george	PROPN
bam-7218	252	26	cairns	cairns	PROPN
bam-7218	252	27	(	(	PUNCT
bam-7218	252	28	a	a	NOUN
bam-7218	252	29	)	)	PUNCT
bam-7218	252	30	andreas	andreas	PROPN
bam-7218	252	31	roos	roo	NOUN
bam-7218	252	32	(	(	PUNCT
bam-7218	252	33	a	a	DET
bam-7218	252	34	,	,	PUNCT
bam-7218	252	35	b	b	NOUN
bam-7218	252	36	)	)	PUNCT
bam-7218	252	37	,	,	PUNCT
bam-7218	252	38	hanns	hann	NOUN
bam-7218	252	39	lochmüller	lochmüll	ADJ
bam-7218	252	40	(	(	PUNCT
bam-7218	252	41	a	a	NOUN
bam-7218	252	42	)	)	PUNCT
bam-7218	252	43	(	(	PUNCT
bam-7218	252	44	a	a	PRON
bam-7218	252	45	)	)	PUNCT
bam-7218	252	46	institute	institute	NOUN
bam-7218	252	47	of	of	ADP
bam-7218	252	48	genetic	genetic	ADJ
bam-7218	252	49	medicine	medicine	NOUN
bam-7218	252	50	,	,	PUNCT
bam-7218	252	51	newcastle	newcastle	PROPN
bam-7218	252	52	university	university	PROPN
bam-7218	252	53	,	,	PUNCT
bam-7218	252	54	uk	uk	PROPN
bam-7218	252	55	.	.	PUNCT
bam-7218	252	56	(	(	PUNCT
bam-7218	252	57	b	b	X
bam-7218	252	58	)	)	PUNCT
bam-7218	252	59	leibniz	leibniz	PROPN
bam-7218	252	60	-	-	PUNCT
bam-7218	252	61	institut	institut	PROPN
bam-7218	252	62	für	für	PROPN
bam-7218	252	63	analytische	analytische	PROPN
bam-7218	252	64	wissenschaftenisas	wissenschaftenisas	PROPN
bam-7218	253	1	e.v	e.v	PROPN
bam-7218	253	2	,	,	PUNCT
bam-7218	253	3	germany	germany	PROPN
bam-7218	253	4	.	.	PUNCT
bam-7218	254	1	e	e	X
bam-7218	254	2	-	-	NOUN
bam-7218	254	3	mail	mail	NOUN
bam-7218	254	4	:	:	PUNCT
bam-7218	254	5	e.a.oconnor@ncl.ac.uk	e.a.oconnor@ncl.ac.uk	PROPN
bam-7218	254	6	congenital	congenital	ADJ
bam-7218	254	7	myasthenic	myasthenic	ADJ
bam-7218	254	8	syndromes	syndrome	NOUN
bam-7218	254	9	(	(	PUNCT
bam-7218	254	10	cms	cms	NOUN
bam-7218	254	11	)	)	PUNCT
bam-7218	254	12	are	be	AUX
bam-7218	254	13	a	a	DET
bam-7218	254	14	group	group	NOUN
bam-7218	254	15	of	of	ADP
bam-7218	254	16	rare	rare	ADJ
bam-7218	254	17	,	,	PUNCT
bam-7218	254	18	inherited	inherit	VERB
bam-7218	254	19	disorders	disorder	NOUN
bam-7218	254	20	characterised	characterise	VERB
bam-7218	254	21	by	by	ADP
bam-7218	254	22	compromised	compromise	VERB
bam-7218	254	23	function	function	NOUN
bam-7218	254	24	of	of	ADP
bam-7218	254	25	the	the	DET
bam-7218	254	26	neuromuscular	neuromuscular	ADJ
bam-7218	254	27	junction	junction	NOUN
bam-7218	254	28	(	(	PUNCT
bam-7218	254	29	nmj	nmj	NOUN
bam-7218	254	30	)	)	PUNCT
bam-7218	254	31	manifesting	manifest	VERB
bam-7218	254	32	with	with	ADP
bam-7218	254	33	fatigable	fatigable	ADJ
bam-7218	254	34	muscle	muscle	NOUN
bam-7218	254	35	weakness	weakness	NOUN
bam-7218	254	36	.	.	PUNCT
bam-7218	255	1	we	we	PRON
bam-7218	255	2	identified	identify	VERB
bam-7218	255	3	mutations	mutation	NOUN
bam-7218	255	4	in	in	ADP
bam-7218	255	5	myo9a	myo9a	PROPN
bam-7218	255	6	as	as	ADP
bam-7218	255	7	causative	causative	ADJ
bam-7218	255	8	for	for	ADP
bam-7218	255	9	cms	cms	NOUN
bam-7218	255	10	but	but	CCONJ
bam-7218	255	11	the	the	DET
bam-7218	255	12	precise	precise	ADJ
bam-7218	255	13	pathomechanism	pathomechanism	NOUN
bam-7218	255	14	remained	remain	VERB
bam-7218	255	15	to	to	PART
bam-7218	255	16	be	be	AUX
bam-7218	255	17	characterised	characterise	VERB
bam-7218	255	18	.	.	PUNCT
bam-7218	256	1	we	we	PRON
bam-7218	256	2	hypothesised	hypothesise	VERB
bam-7218	256	3	that	that	SCONJ
bam-7218	256	4	defects	defect	NOUN
bam-7218	256	5	in	in	ADP
bam-7218	256	6	myo9a	myo9a	PROPN
bam-7218	256	7	affect	affect	VERB
bam-7218	256	8	the	the	DET
bam-7218	256	9	neuronal	neuronal	ADJ
bam-7218	256	10	cytoskeleton	cytoskeleton	NOUN
bam-7218	256	11	,	,	PUNCT
bam-7218	256	12	thus	thus	ADV
bam-7218	256	13	leading	lead	VERB
bam-7218	256	14	to	to	ADP
bam-7218	256	15	impaired	impaired	ADJ
bam-7218	256	16	vesicular	vesicular	ADJ
bam-7218	256	17	transport	transport	NOUN
bam-7218	256	18	.	.	PUNCT
bam-7218	257	1	myo9a	myo9a	ADJ
bam-7218	257	2	-	-	PUNCT
bam-7218	257	3	depleted	deplete	VERB
bam-7218	257	4	nsc34	nsc34	NOUN
bam-7218	257	5	cells	cell	NOUN
bam-7218	257	6	(	(	PUNCT
bam-7218	257	7	mouse	mouse	PROPN
bam-7218	257	8	motor	motor	PROPN
bam-7218	257	9	neuron	neuron	NOUN
bam-7218	257	10	-	-	PUNCT
bam-7218	257	11	derived	derive	VERB
bam-7218	257	12	cells	cell	NOUN
bam-7218	257	13	)	)	PUNCT
bam-7218	257	14	were	be	AUX
bam-7218	257	15	used	use	VERB
bam-7218	257	16	to	to	PART
bam-7218	257	17	assess	assess	VERB
bam-7218	257	18	the	the	DET
bam-7218	257	19	effect	effect	NOUN
bam-7218	257	20	on	on	ADP
bam-7218	257	21	the	the	DET
bam-7218	257	22	cytoskeleton	cytoskeleton	NOUN
bam-7218	257	23	using	use	VERB
bam-7218	257	24	immunofluorescent	immunofluorescent	VERB
bam-7218	257	25	and	and	CCONJ
bam-7218	257	26	immunoblotting	immunoblotte	VERB
bam-7218	257	27	techniques	technique	NOUN
bam-7218	257	28	.	.	PUNCT
bam-7218	258	1	vesicular	vesicular	ADJ
bam-7218	258	2	transport	transport	NOUN
bam-7218	258	3	was	be	AUX
bam-7218	258	4	analysed	analyse	VERB
bam-7218	258	5	using	use	VERB
bam-7218	258	6	different	different	ADJ
bam-7218	258	7	assays	assay	NOUN
bam-7218	258	8	including	include	VERB
bam-7218	258	9	a	a	DET
bam-7218	258	10	secretomic	secretomic	ADJ
bam-7218	258	11	study	study	NOUN
bam-7218	258	12	to	to	PART
bam-7218	258	13	identify	identify	VERB
bam-7218	258	14	factors	factor	NOUN
bam-7218	258	15	released	release	VERB
bam-7218	258	16	from	from	ADP
bam-7218	258	17	the	the	DET
bam-7218	258	18	nerve	nerve	NOUN
bam-7218	258	19	to	to	PART
bam-7218	258	20	act	act	VERB
bam-7218	258	21	on	on	ADP
bam-7218	258	22	the	the	DET
bam-7218	258	23	muscle	muscle	NOUN
bam-7218	258	24	fibre	fibre	NOUN
bam-7218	258	25	for	for	ADP
bam-7218	258	26	nmj	nmj	NOUN
bam-7218	258	27	development	development	NOUN
bam-7218	258	28	and	and	CCONJ
bam-7218	258	29	function	function	NOUN
bam-7218	258	30	.	.	PUNCT
bam-7218	259	1	in	in	ADP
bam-7218	259	2	addition	addition	NOUN
bam-7218	259	3	,	,	PUNCT
bam-7218	259	4	an	an	DET
bam-7218	259	5	unbiased	unbiased	ADJ
bam-7218	259	6	approach	approach	NOUN
bam-7218	259	7	utilising	utilise	VERB
bam-7218	259	8	proteomic	proteomic	ADJ
bam-7218	259	9	profiling	profiling	NOUN
bam-7218	259	10	of	of	ADP
bam-7218	259	11	control	control	NOUN
bam-7218	259	12	and	and	CCONJ
bam-7218	259	13	myo9a	myo9a	NOUN
bam-7218	259	14	-	-	PUNCT
bam-7218	259	15	depleted	deplete	VERB
bam-7218	259	16	nsc-34	nsc-34	NUM
bam-7218	259	17	cells	cell	NOUN
bam-7218	259	18	was	be	AUX
bam-7218	259	19	performed	perform	VERB
bam-7218	259	20	to	to	PART
bam-7218	259	21	identify	identify	VERB
bam-7218	259	22	key	key	ADJ
bam-7218	259	23	players	player	NOUN
bam-7218	259	24	of	of	ADP
bam-7218	259	25	the	the	DET
bam-7218	259	26	pathophysiology	pathophysiology	NOUN
bam-7218	259	27	.	.	PUNCT
bam-7218	260	1	disruption	disruption	NOUN
bam-7218	260	2	of	of	ADP
bam-7218	260	3	the	the	DET
bam-7218	260	4	cytoskeleton	cytoskeleton	NOUN
bam-7218	260	5	has	have	AUX
bam-7218	260	6	been	be	AUX
bam-7218	260	7	identified	identify	VERB
bam-7218	260	8	in	in	ADP
bam-7218	260	9	myo9adepleted	myo9adepleted	PROPN
bam-7218	260	10	cells	cell	NOUN
bam-7218	260	11	,	,	PUNCT
bam-7218	260	12	with	with	SCONJ
bam-7218	260	13	corresponding	correspond	VERB
bam-7218	260	14	defects	defect	NOUN
bam-7218	260	15	in	in	ADP
bam-7218	260	16	receptor	receptor	NOUN
bam-7218	260	17	recycling	recycling	NOUN
bam-7218	260	18	and	and	CCONJ
bam-7218	260	19	regular	regular	ADJ
bam-7218	260	20	transport	transport	NOUN
bam-7218	260	21	of	of	ADP
bam-7218	260	22	proteins	protein	NOUN
bam-7218	260	23	to	to	ADP
bam-7218	260	24	the	the	DET
bam-7218	260	25	cell	cell	NOUN
bam-7218	260	26	surface	surface	NOUN
bam-7218	260	27	also	also	ADV
bam-7218	260	28	observed	observe	VERB
bam-7218	260	29	.	.	PUNCT
bam-7218	261	1	proteomic	proteomic	ADJ
bam-7218	261	2	data	datum	NOUN
bam-7218	261	3	support	support	VERB
bam-7218	261	4	a	a	DET
bam-7218	261	5	role	role	NOUN
bam-7218	261	6	for	for	ADP
bam-7218	261	7	defective	defective	ADJ
bam-7218	261	8	vesicular	vesicular	ADJ
bam-7218	261	9	transport	transport	NOUN
bam-7218	261	10	and	and	CCONJ
bam-7218	261	11	identified	identify	VERB
bam-7218	261	12	affected	affect	VERB
bam-7218	261	13	proteins	protein	NOUN
bam-7218	261	14	which	which	PRON
bam-7218	261	15	are	be	AUX
bam-7218	261	16	also	also	ADV
bam-7218	261	17	involved	involve	VERB
bam-7218	261	18	in	in	ADP
bam-7218	261	19	the	the	DET
bam-7218	261	20	manifestation	manifestation	NOUN
bam-7218	261	21	of	of	ADP
bam-7218	261	22	other	other	ADJ
bam-7218	261	23	neuromuscular	neuromuscular	ADJ
bam-7218	261	24	disorders	disorder	NOUN
bam-7218	261	25	.	.	PUNCT
bam-7218	262	1	furthermore	furthermore	ADV
bam-7218	262	2	,	,	PUNCT
bam-7218	262	3	a	a	DET
bam-7218	262	4	therapeutic	therapeutic	ADJ
bam-7218	262	5	target	target	NOUN
bam-7218	262	6	was	be	AUX
bam-7218	262	7	identified	identify	VERB
bam-7218	262	8	and	and	CCONJ
bam-7218	262	9	treatment	treatment	NOUN
bam-7218	262	10	of	of	ADP
bam-7218	262	11	our	our	PRON
bam-7218	262	12	myo9a	myo9a	PROPN
bam-7218	262	13	zebrafish	zebrafish	ADJ
bam-7218	262	14	model	model	NOUN
bam-7218	262	15	was	be	AUX
bam-7218	262	16	able	able	ADJ
bam-7218	262	17	to	to	PART
bam-7218	262	18	ameliorate	ameliorate	VERB
bam-7218	262	19	movement	movement	NOUN
bam-7218	262	20	defects	defect	NOUN
bam-7218	262	21	,	,	PUNCT
bam-7218	262	22	increase	increase	VERB
bam-7218	262	23	muscle	muscle	NOUN
bam-7218	262	24	mass	mass	NOUN
bam-7218	262	25	and	and	CCONJ
bam-7218	262	26	improve	improve	VERB
bam-7218	262	27	muscle	muscle	NOUN
bam-7218	262	28	innervation	innervation	NOUN
bam-7218	262	29	.	.	PUNCT
bam-7218	263	1	our	our	PRON
bam-7218	263	2	combined	combined	ADJ
bam-7218	263	3	data	datum	NOUN
bam-7218	263	4	allow	allow	VERB
bam-7218	263	5	new	new	ADJ
bam-7218	263	6	insights	insight	NOUN
bam-7218	263	7	into	into	ADP
bam-7218	263	8	the	the	DET
bam-7218	263	9	pathophysiology	pathophysiology	NOUN
bam-7218	263	10	of	of	ADP
bam-7218	263	11	cms	cms	NOUN
bam-7218	263	12	and	and	CCONJ
bam-7218	263	13	show	show	VERB
bam-7218	263	14	that	that	SCONJ
bam-7218	263	15	loss	loss	NOUN
bam-7218	263	16	of	of	ADP
bam-7218	263	17	myo9a	myo9a	PROPN
bam-7218	263	18	affects	affect	VERB
bam-7218	263	19	the	the	DET
bam-7218	263	20	neuronal	neuronal	ADJ
bam-7218	263	21	cytoskeleton	cytoskeleton	NOUN
bam-7218	263	22	,	,	PUNCT
bam-7218	263	23	leading	lead	VERB
bam-7218	263	24	to	to	ADP
bam-7218	263	25	impaired	impaired	ADJ
bam-7218	263	26	transport	transport	NOUN
bam-7218	263	27	and	and	CCONJ
bam-7218	263	28	vesicular	vesicular	ADJ
bam-7218	263	29	recycling	recycling	NOUN
bam-7218	263	30	of	of	ADP
bam-7218	263	31	proteins	protein	NOUN
bam-7218	263	32	.	.	PUNCT
bam-7218	264	1	we	we	PRON
bam-7218	264	2	also	also	ADV
bam-7218	264	3	identified	identify	VERB
bam-7218	264	4	a	a	DET
bam-7218	264	5	protein	protein	NOUN
bam-7218	264	6	of	of	ADP
bam-7218	264	7	potential	potential	ADJ
bam-7218	264	8	therapeutic	therapeutic	ADJ
bam-7218	264	9	importance	importance	NOUN
bam-7218	264	10	for	for	ADP
bam-7218	264	11	patients	patient	NOUN
bam-7218	264	12	.	.	PUNCT
bam-7218	265	1	1.6	1.6	NUM
bam-7218	265	2	organelle	organelle	NOUN
bam-7218	265	3	pathology	pathology	NOUN
bam-7218	265	4	affecting	affect	VERB
bam-7218	265	5	protein	protein	NOUN
bam-7218	265	6	processing	processing	NOUN
bam-7218	265	7	and	and	CCONJ
bam-7218	265	8	clearance	clearance	NOUN
bam-7218	265	9	in	in	ADP
bam-7218	265	10	myotonic	myotonic	ADJ
bam-7218	265	11	dystrophy	dystrophy	NOUN
bam-7218	265	12	type	type	NOUN
bam-7218	265	13	1	1	NUM
bam-7218	265	14	angus	angus	NOUN
bam-7218	265	15	isham	isham	PROPN
bam-7218	265	16	(	(	PUNCT
bam-7218	265	17	a	a	PROPN
bam-7218	265	18	)	)	PUNCT
bam-7218	265	19	,	,	PUNCT
bam-7218	265	20	charlie	charlie	PROPN
bam-7218	265	21	bowers	bowers	PROPN
bam-7218	265	22	(	(	PUNCT
bam-7218	265	23	a	a	X
bam-7218	265	24	)	)	PUNCT
bam-7218	265	25	,	,	PUNCT
bam-7218	265	26	emily	emily	PROPN
bam-7218	265	27	o´connor	o´connor	PROPN
bam-7218	265	28	(	(	PUNCT
bam-7218	265	29	a	a	NOUN
bam-7218	265	30	)	)	PUNCT
bam-7218	265	31	,	,	PUNCT
bam-7218	265	32	denisa	denisa	NOUN
bam-7218	265	33	hathazi	hathazi	NOUN
bam-7218	265	34	(	(	PUNCT
bam-7218	265	35	b	b	NOUN
bam-7218	265	36	)	)	PUNCT
bam-7218	265	37	,	,	PUNCT
bam-7218	265	38	aura	aura	NOUN
bam-7218	265	39	cecilia	cecilia	PROPN
bam-7218	265	40	jimenez	jimenez	PROPN
bam-7218	265	41	-	-	PUNCT
bam-7218	265	42	moreno	moreno	PROPN
bam-7218	265	43	(	(	PUNCT
bam-7218	265	44	a	a	PROPN
bam-7218	265	45	)	)	PUNCT
bam-7218	265	46	,	,	PUNCT
bam-7218	265	47	oksana	oksana	PROPN
bam-7218	265	48	pogoryelova	pogoryelova	PROPN
bam-7218	265	49	(	(	PUNCT
bam-7218	265	50	a	a	X
bam-7218	265	51	)	)	PUNCT
bam-7218	265	52	,	,	PUNCT
bam-7218	265	53	denis	denis	PROPN
bam-7218	265	54	furling	furling	NOUN
bam-7218	265	55	(	(	PUNCT
bam-7218	265	56	c	c	NOUN
bam-7218	265	57	)	)	PUNCT
bam-7218	265	58	,	,	PUNCT
bam-7218	265	59	ingrid	ingrid	PROPN
bam-7218	265	60	verhaart	verhaart	PROPN
bam-7218	265	61	(	(	PUNCT
bam-7218	265	62	a	a	NOUN
bam-7218	265	63	)	)	PUNCT
bam-7218	265	64	,	,	PUNCT
bam-7218	265	65	nikoletta	nikoletta	PROPN
bam-7218	265	66	nikolenko	nikolenko	PROPN
bam-7218	265	67	(	(	PUNCT
bam-7218	265	68	a	a	NOUN
bam-7218	265	69	)	)	PUNCT
bam-7218	265	70	,	,	PUNCT
bam-7218	265	71	hanns	hann	NOUN
bam-7218	265	72	lochmüller	lochmüll	ADJ
bam-7218	265	73	(	(	PUNCT
bam-7218	265	74	a	a	PROPN
bam-7218	265	75	)	)	PUNCT
bam-7218	265	76	,	,	PUNCT
bam-7218	265	77	andreas	andreas	PROPN
bam-7218	265	78	roos	roos	PROPN
bam-7218	265	79	(	(	PUNCT
bam-7218	265	80	a	a	DET
bam-7218	265	81	,	,	PUNCT
bam-7218	265	82	b	b	NOUN
bam-7218	265	83	)	)	PUNCT
bam-7218	265	84	(	(	PUNCT
bam-7218	265	85	a	a	PRON
bam-7218	265	86	)	)	PUNCT
bam-7218	265	87	institute	institute	NOUN
bam-7218	265	88	of	of	ADP
bam-7218	265	89	genetic	genetic	ADJ
bam-7218	265	90	medicine	medicine	NOUN
bam-7218	265	91	,	,	PUNCT
bam-7218	265	92	international	international	ADJ
bam-7218	265	93	centre	centre	NOUN
bam-7218	265	94	for	for	ADP
bam-7218	265	95	life	life	NOUN
bam-7218	265	96	,	,	PUNCT
bam-7218	265	97	central	central	ADJ
bam-7218	265	98	parkway	parkway	NOUN
bam-7218	265	99	,	,	PUNCT
bam-7218	265	100	newcastle	newcastle	PROPN
bam-7218	265	101	upon	upon	SCONJ
bam-7218	265	102	tyne	tyne	PROPN
bam-7218	265	103	,	,	PUNCT
bam-7218	265	104	england	england	PROPN
bam-7218	265	105	,	,	PUNCT
bam-7218	265	106	uk	uk	PROPN
bam-7218	265	107	.	.	PUNCT
bam-7218	265	108	(	(	PUNCT
bam-7218	265	109	b	b	X
bam-7218	265	110	)	)	PUNCT
bam-7218	265	111	leibniz	leibniz	PROPN
bam-7218	265	112	-	-	PUNCT
bam-7218	265	113	institut	institut	PROPN
bam-7218	265	114	für	für	PROPN
bam-7218	265	115	analytische	analytische	PROPN
bam-7218	265	116	wissenschaften	wissenschaften	VERB
bam-7218	265	117	isas	isas	PROPN
bam-7218	266	1	e.v	e.v	PROPN
bam-7218	266	2	,	,	PUNCT
bam-7218	266	3	dortmund	dortmund	PROPN
bam-7218	266	4	,	,	PUNCT
bam-7218	266	5	germany	germany	PROPN
bam-7218	266	6	;	;	PUNCT
bam-7218	266	7	(	(	PUNCT
bam-7218	266	8	c	c	X
bam-7218	266	9	)	)	PUNCT
bam-7218	266	10	institute	institute	NOUN
bam-7218	266	11	of	of	ADP
bam-7218	266	12	myology	myology	PROPN
bam-7218	266	13	,	,	PUNCT
bam-7218	266	14	paris	paris	PROPN
bam-7218	266	15	,	,	PUNCT
bam-7218	266	16	france	france	PROPN
bam-7218	266	17	.	.	PUNCT
bam-7218	267	1	e	e	X
bam-7218	267	2	-	-	NOUN
bam-7218	267	3	mail	mail	NOUN
bam-7218	267	4	:	:	PUNCT
bam-7218	267	5	andreas.roos@ncl.ac.uk	andreas.roos@ncl.ac.uk	VERB
bam-7218	267	6	myotonic	myotonic	ADJ
bam-7218	267	7	dystrophy	dystrophy	NOUN
bam-7218	267	8	is	be	AUX
bam-7218	267	9	the	the	DET
bam-7218	267	10	most	most	ADV
bam-7218	267	11	common	common	ADJ
bam-7218	267	12	adult	adult	NOUN
bam-7218	267	13	onset	onset	VERB
bam-7218	267	14	muscular	muscular	ADJ
bam-7218	267	15	dystrophy	dystrophy	NOUN
bam-7218	267	16	and	and	CCONJ
bam-7218	267	17	2	2	NUM
bam-7218	267	18	major	major	ADJ
bam-7218	267	19	forms	form	NOUN
bam-7218	267	20	have	have	AUX
bam-7218	267	21	been	be	AUX
bam-7218	267	22	identified	identify	VERB
bam-7218	267	23	based	base	VERB
bam-7218	267	24	on	on	ADP
bam-7218	267	25	distinct	distinct	ADJ
bam-7218	267	26	genetic	genetic	ADJ
bam-7218	267	27	mutations	mutation	NOUN
bam-7218	267	28	.	.	PUNCT
bam-7218	268	1	myotonic	myotonic	ADJ
bam-7218	268	2	dystrophy	dystrophy	NOUN
bam-7218	268	3	type	type	NOUN
bam-7218	268	4	1	1	NUM
bam-7218	268	5	(	(	PUNCT
bam-7218	268	6	dm1	dm1	NOUN
bam-7218	268	7	)	)	PUNCT
bam-7218	268	8	is	be	AUX
bam-7218	268	9	caused	cause	VERB
bam-7218	268	10	by	by	ADP
bam-7218	268	11	(	(	PUNCT
bam-7218	268	12	ctg)n	ctg)n	PROPN
bam-7218	268	13	trinucleotide	trinucleotide	NOUN
bam-7218	268	14	repeat	repeat	NOUN
bam-7218	268	15	expansion	expansion	NOUN
bam-7218	268	16	in	in	ADP
bam-7218	268	17	the	the	DET
bam-7218	268	18	3	3	NUM
bam-7218	268	19	’	'	PUNCT
bam-7218	268	20	untranslated	untranslated	ADJ
bam-7218	268	21	region	region	NOUN
bam-7218	268	22	of	of	ADP
bam-7218	268	23	the	the	DET
bam-7218	268	24	dmpk	dmpk	NOUN
bam-7218	268	25	gene	gene	NOUN
bam-7218	268	26	and	and	CCONJ
bam-7218	268	27	displays	display	VERB
bam-7218	268	28	an	an	DET
bam-7218	268	29	autosomal	autosomal	ADJ
bam-7218	268	30	dominant	dominant	ADJ
bam-7218	268	31	mode	mode	NOUN
bam-7218	268	32	of	of	ADP
bam-7218	268	33	inheritance	inheritance	NOUN
bam-7218	268	34	.	.	PUNCT
bam-7218	269	1	patients	patient	NOUN
bam-7218	269	2	present	present	ADJ
bam-7218	269	3	with	with	ADP
bam-7218	269	4	myotonia	myotonia	NOUN
bam-7218	269	5	,	,	PUNCT
bam-7218	269	6	muscular	muscular	ADJ
bam-7218	269	7	weakness	weakness	NOUN
bam-7218	269	8	,	,	PUNCT
bam-7218	269	9	cardiac	cardiac	ADJ
bam-7218	269	10	arrhythmia	arrhythmia	NOUN
bam-7218	269	11	,	,	PUNCT
bam-7218	269	12	and	and	CCONJ
bam-7218	269	13	visual	visual	ADJ
bam-7218	269	14	disturbances	disturbance	NOUN
bam-7218	269	15	.	.	PUNCT
bam-7218	270	1	the	the	DET
bam-7218	270	2	repeat	repeat	NOUN
bam-7218	270	3	expansion	expansion	NOUN
bam-7218	270	4	causes	cause	VERB
bam-7218	270	5	the	the	DET
bam-7218	270	6	disease	disease	NOUN
bam-7218	270	7	through	through	ADP
bam-7218	270	8	a	a	DET
bam-7218	270	9	toxic	toxic	ADJ
bam-7218	270	10	rna	rna	NOUN
bam-7218	270	11	product	product	NOUN
bam-7218	270	12	clustering	cluster	VERB
bam-7218	270	13	rna	rna	NOUN
bam-7218	270	14	processing	processing	NOUN
bam-7218	270	15	factors	factor	NOUN
bam-7218	270	16	.	.	PUNCT
bam-7218	271	1	mis	mi	NOUN
bam-7218	271	2	-	-	NOUN
bam-7218	271	3	splicing	splicing	NOUN
bam-7218	271	4	of	of	ADP
bam-7218	271	5	diverse	diverse	ADJ
bam-7218	271	6	transcripts	transcript	NOUN
bam-7218	271	7	has	have	AUX
bam-7218	271	8	been	be	AUX
bam-7218	271	9	observed	observe	VERB
bam-7218	271	10	in	in	ADP
bam-7218	271	11	dm1	dm1	PROPN
bam-7218	271	12	resulting	result	VERB
bam-7218	271	13	in	in	ADP
bam-7218	271	14	presence	presence	NOUN
bam-7218	271	15	of	of	ADP
bam-7218	271	16	aberrant	aberrant	ADJ
bam-7218	271	17	proteins	protein	NOUN
bam-7218	271	18	and/or	and/or	CCONJ
bam-7218	271	19	perturbed	perturb	VERB
bam-7218	271	20	protein	protein	NOUN
bam-7218	271	21	abundances	abundance	NOUN
bam-7218	271	22	such	such	ADJ
bam-7218	271	23	as	as	ADP
bam-7218	271	24	for	for	ADP
bam-7218	271	25	the	the	DET
bam-7218	271	26	sr	sr	PROPN
bam-7218	271	27	resident	resident	PROPN
bam-7218	271	28	serca	serca	PROPN
bam-7218	271	29	.	.	PUNCT
bam-7218	272	1	affection	affection	NOUN
bam-7218	272	2	of	of	ADP
bam-7218	272	3	the	the	DET
bam-7218	272	4	latter	latter	ADJ
bam-7218	272	5	protein	protein	NOUN
bam-7218	272	6	leading	lead	VERB
bam-7218	272	7	to	to	PART
bam-7218	272	8	perturbed	perturb	VERB
bam-7218	272	9	ca2	ca2	PROPN
bam-7218	272	10	+	+	CCONJ
bam-7218	272	11	sr	sr	PROPN
bam-7218	272	12	homeostasis	homeostasis	NOUN
bam-7218	272	13	is	be	AUX
bam-7218	272	14	in	in	ADP
bam-7218	272	15	accordance	accordance	NOUN
bam-7218	272	16	with	with	ADP
bam-7218	272	17	the	the	DET
bam-7218	272	18	few	few	ADJ
bam-7218	272	19	descriptions	description	NOUN
bam-7218	272	20	of	of	ADP
bam-7218	272	21	perturbed	perturb	VERB
bam-7218	272	22	er	er	INTJ
bam-7218	272	23	/	/	SYM
bam-7218	272	24	sr	sr	NOUN
bam-7218	272	25	-	-	PUNCT
bam-7218	272	26	homeostasis	homeostasis	NOUN
bam-7218	272	27	.	.	PUNCT
bam-7218	273	1	as	as	SCONJ
bam-7218	273	2	the	the	DET
bam-7218	273	3	er	er	INTJ
bam-7218	273	4	/	/	SYM
bam-7218	273	5	sr	sr	PROPN
bam-7218	273	6	is	be	AUX
bam-7218	273	7	connected	connect	VERB
bam-7218	273	8	to	to	ADP
bam-7218	273	9	the	the	DET
bam-7218	273	10	golgi	golgi	NOUN
bam-7218	273	11	,	,	PUNCT
bam-7218	273	12	an	an	DET
bam-7218	273	13	affection	affection	NOUN
bam-7218	273	14	of	of	ADP
bam-7218	273	15	these	these	DET
bam-7218	273	16	protein	protein	NOUN
bam-7218	273	17	processing	process	VERB
bam-7218	273	18	compartments	compartment	NOUN
bam-7218	273	19	is	be	AUX
bam-7218	273	20	very	very	ADV
bam-7218	273	21	likely	likely	ADJ
bam-7218	273	22	and	and	CCONJ
bam-7218	273	23	presumably	presumably	ADV
bam-7218	273	24	affects	affect	VERB
bam-7218	273	25	folding	fold	VERB
bam-7218	273	26	and	and	CCONJ
bam-7218	273	27	glycosylation	glycosylation	NOUN
bam-7218	273	28	of	of	ADP
bam-7218	273	29	further	further	ADJ
bam-7218	273	30	proteins	protein	NOUN
bam-7218	273	31	.	.	PUNCT
bam-7218	274	1	however	however	ADV
bam-7218	274	2	,	,	PUNCT
bam-7218	274	3	as	as	SCONJ
bam-7218	274	4	there	there	PRON
bam-7218	274	5	remains	remain	VERB
bam-7218	274	6	a	a	DET
bam-7218	274	7	lack	lack	NOUN
bam-7218	274	8	in	in	ADP
bam-7218	274	9	the	the	DET
bam-7218	274	10	understanding	understanding	NOUN
bam-7218	274	11	of	of	ADP
bam-7218	274	12	organelle	organelle	NOUN
bam-7218	274	13	pathology	pathology	NOUN
bam-7218	274	14	in	in	ADP
bam-7218	274	15	dm1	dm1	PROPN
bam-7218	274	16	,	,	PUNCT
bam-7218	274	17	we	we	PRON
bam-7218	274	18	here	here	ADV
bam-7218	274	19	systematically	systematically	ADV
bam-7218	274	20	addressed	address	VERB
bam-7218	274	21	this	this	DET
bam-7218	274	22	topic	topic	NOUN
bam-7218	274	23	:	:	PUNCT
bam-7218	274	24	utilizing	utilize	VERB
bam-7218	274	25	patient	patient	NOUN
bam-7218	274	26	and	and	CCONJ
bam-7218	274	27	animal	animal	NOUN
bam-7218	274	28	model	model	NOUN
bam-7218	274	29	-	-	PUNCT
bam-7218	274	30	derived	derive	VERB
bam-7218	274	31	material	material	NOUN
bam-7218	274	32	we	we	PRON
bam-7218	274	33	studied	study	VERB
bam-7218	274	34	(	(	PUNCT
bam-7218	274	35	i	i	NOUN
bam-7218	274	36	)	)	PUNCT
bam-7218	274	37	organelle	organelle	NOUN
bam-7218	274	38	integrity	integrity	NOUN
bam-7218	274	39	,	,	PUNCT
bam-7218	274	40	(	(	PUNCT
bam-7218	274	41	ii	ii	NOUN
bam-7218	274	42	)	)	PUNCT
bam-7218	274	43	cellular	cellular	ADJ
bam-7218	274	44	mailto:e.a.oconnor@ncl.ac.uk	mailto:e.a.oconnor@ncl.ac.uk	NOUN
bam-7218	275	1	mailto:andreas.roos@ncl.ac.uk	mailto:andreas.roos@ncl.ac.uk	PROPN
bam-7218	275	2	14	14	NUM
bam-7218	275	3	th	th	NOUN
bam-7218	275	4	iiim	iiim	NOUN
bam-7218	275	5	meeting	meeting	NOUN
bam-7218	275	6	,	,	PUNCT
bam-7218	275	7	assisi	assisi	PROPN
bam-7218	275	8	,	,	PUNCT
bam-7218	275	9	italy	italy	PROPN
bam-7218	275	10	october	october	PROPN
bam-7218	275	11	12	12	NUM
bam-7218	275	12	-	-	SYM
bam-7218	275	13	15	15	NUM
bam-7218	275	14	2017	2017	NUM
bam-7218	275	15	eur	eur	PROPN
bam-7218	275	16	j	j	PROPN
bam-7218	275	17	transl	transl	PROPN
bam-7218	275	18	myol	myol	ADV
bam-7218	275	19	27	27	NUM
bam-7218	275	20	(	(	PUNCT
bam-7218	275	21	4	4	NUM
bam-7218	275	22	):	):	SYM
bam-7218	275	23	185	185	NUM
bam-7218	275	24	-	-	SYM
bam-7218	275	25	224	224	NUM
bam-7218	275	26	192	192	NUM
bam-7218	275	27	fitness	fitness	NOUN
bam-7218	275	28	,	,	PUNCT
bam-7218	275	29	and	and	CCONJ
bam-7218	275	30	(	(	PUNCT
bam-7218	275	31	iii	iii	NOUN
bam-7218	275	32	)	)	PUNCT
bam-7218	275	33	protein	protein	NOUN
bam-7218	275	34	abundances	abundance	NOUN
bam-7218	275	35	(	(	PUNCT
bam-7218	275	36	proteomics	proteomic	NOUN
bam-7218	275	37	and	and	CCONJ
bam-7218	275	38	immunoblot	immunoblot	NOUN
bam-7218	275	39	)	)	PUNCT
bam-7218	275	40	including	include	VERB
bam-7218	275	41	(	(	PUNCT
bam-7218	275	42	iv	iv	X
bam-7218	275	43	)	)	PUNCT
bam-7218	275	44	the	the	DET
bam-7218	275	45	study	study	NOUN
bam-7218	275	46	of	of	ADP
bam-7218	275	47	glycoproteins	glycoprotein	NOUN
bam-7218	275	48	.	.	PUNCT
bam-7218	276	1	moreover	moreover	ADV
bam-7218	276	2	,	,	PUNCT
bam-7218	276	3	(	(	PUNCT
bam-7218	276	4	v	v	NOUN
bam-7218	276	5	)	)	PUNCT
bam-7218	276	6	rna	rna	NOUN
bam-7218	276	7	-	-	PUNCT
bam-7218	276	8	seq	seq	NOUN
bam-7218	276	9	and	and	CCONJ
bam-7218	276	10	(	(	PUNCT
bam-7218	276	11	vi	vi	NOUN
bam-7218	276	12	)	)	PUNCT
bam-7218	276	13	measurements	measurement	NOUN
bam-7218	276	14	of	of	ADP
bam-7218	276	15	protein	protein	NOUN
bam-7218	276	16	clearance	clearance	NOUN
bam-7218	276	17	have	have	AUX
bam-7218	276	18	been	be	AUX
bam-7218	276	19	performed	perform	VERB
bam-7218	276	20	.	.	PUNCT
bam-7218	277	1	our	our	PRON
bam-7218	277	2	combined	combined	ADJ
bam-7218	277	3	data	datum	NOUN
bam-7218	277	4	reveal	reveal	VERB
bam-7218	277	5	profound	profound	ADJ
bam-7218	277	6	overall	overall	ADJ
bam-7218	277	7	affection	affection	NOUN
bam-7218	277	8	of	of	ADP
bam-7218	277	9	the	the	DET
bam-7218	277	10	er	er	INTJ
bam-7218	277	11	-	-	PUNCT
bam-7218	277	12	golgi	golgi	NOUN
bam-7218	277	13	machinery	machinery	NOUN
bam-7218	277	14	along	along	ADP
bam-7218	277	15	with	with	ADP
bam-7218	277	16	affection	affection	NOUN
bam-7218	277	17	of	of	ADP
bam-7218	277	18	the	the	DET
bam-7218	277	19	protein	protein	NOUN
bam-7218	277	20	clearance	clearance	NOUN
bam-7218	277	21	machinery	machinery	NOUN
bam-7218	277	22	and	and	CCONJ
bam-7218	277	23	thus	thus	ADV
bam-7218	277	24	strengthen	strengthen	VERB
bam-7218	277	25	the	the	DET
bam-7218	277	26	current	current	ADJ
bam-7218	277	27	understanding	understanding	NOUN
bam-7218	277	28	of	of	ADP
bam-7218	277	29	the	the	DET
bam-7218	277	30	etiology	etiology	NOUN
bam-7218	277	31	of	of	ADP
bam-7218	277	32	dm1	dm1	PROPN
bam-7218	277	33	and	and	CCONJ
bam-7218	277	34	hereby	hereby	ADV
bam-7218	277	35	open	open	VERB
bam-7218	277	36	new	new	ADJ
bam-7218	277	37	avenues	avenue	NOUN
bam-7218	277	38	for	for	ADP
bam-7218	277	39	therapeutic	therapeutic	ADJ
bam-7218	277	40	intervention	intervention	NOUN
bam-7218	277	41	concepts	concept	NOUN
bam-7218	277	42	.	.	PUNCT
bam-7218	278	1	1.7	1.7	NUM
bam-7218	278	2	lacking	lack	VERB
bam-7218	278	3	of	of	ADP
bam-7218	278	4	nfix	nfix	NOUN
bam-7218	278	5	in	in	ADP
bam-7218	278	6	macrophages	macrophage	NOUN
bam-7218	278	7	induces	induce	VERB
bam-7218	278	8	a	a	DET
bam-7218	278	9	defect	defect	NOUN
bam-7218	278	10	of	of	ADP
bam-7218	278	11	muscle	muscle	NOUN
bam-7218	278	12	regeneration	regeneration	NOUN
bam-7218	278	13	through	through	ADP
bam-7218	278	14	failed	fail	VERB
bam-7218	278	15	phenotypical	phenotypical	ADJ
bam-7218	278	16	switch	switch	NOUN
bam-7218	278	17	marielle	marielle	PROPN
bam-7218	278	18	saclier	saclier	PROPN
bam-7218	278	19	,	,	PUNCT
bam-7218	278	20	giuliana	giuliana	PROPN
bam-7218	278	21	rossi	rossi	PROPN
bam-7218	278	22	,	,	PUNCT
bam-7218	278	23	stefania	stefania	PROPN
bam-7218	278	24	antonini	antonini	PROPN
bam-7218	278	25	,	,	PUNCT
bam-7218	278	26	michela	michela	PROPN
bam-7218	278	27	lapi	lapi	PROPN
bam-7218	278	28	,	,	PUNCT
bam-7218	278	29	chiara	chiara	PROPN
bam-7218	278	30	bonfanti	bonfanti	PROPN
bam-7218	278	31	,	,	PUNCT
bam-7218	278	32	graziella	graziella	PROPN
bam-7218	278	33	messina	messina	PROPN
bam-7218	278	34	dept	dept	PROPN
bam-7218	278	35	of	of	ADP
bam-7218	278	36	biosciences	bioscience	NOUN
bam-7218	278	37	,	,	PUNCT
bam-7218	278	38	university	university	PROPN
bam-7218	278	39	of	of	ADP
bam-7218	278	40	milan	milan	PROPN
bam-7218	278	41	,	,	PUNCT
bam-7218	278	42	italy	italy	PROPN
bam-7218	278	43	.	.	PUNCT
bam-7218	279	1	e	e	X
bam-7218	279	2	-	-	NOUN
bam-7218	279	3	mail	mail	NOUN
bam-7218	279	4	:	:	PUNCT
bam-7218	279	5	marielle.saclier@unimi.it	marielle.saclier@unimi.it	PROPN
bam-7218	279	6	muscle	muscle	PROPN
bam-7218	279	7	development	development	NOUN
bam-7218	279	8	and	and	CCONJ
bam-7218	279	9	skeletal	skeletal	ADJ
bam-7218	279	10	muscle	muscle	NOUN
bam-7218	279	11	regeneration	regeneration	NOUN
bam-7218	279	12	are	be	AUX
bam-7218	279	13	processes	process	NOUN
bam-7218	279	14	which	which	PRON
bam-7218	279	15	required	require	VERB
bam-7218	279	16	specific	specific	ADJ
bam-7218	279	17	and	and	CCONJ
bam-7218	279	18	synchronized	synchronize	VERB
bam-7218	279	19	controlled	control	VERB
bam-7218	279	20	steps	step	NOUN
bam-7218	279	21	.	.	PUNCT
bam-7218	280	1	in	in	ADP
bam-7218	280	2	the	the	DET
bam-7218	280	3	laboratory	laboratory	NOUN
bam-7218	280	4	,	,	PUNCT
bam-7218	280	5	it	it	PRON
bam-7218	280	6	has	have	AUX
bam-7218	280	7	been	be	AUX
bam-7218	280	8	shown	show	VERB
bam-7218	280	9	that	that	SCONJ
bam-7218	280	10	the	the	DET
bam-7218	280	11	transcription	transcription	NOUN
bam-7218	280	12	factor	factor	NOUN
bam-7218	280	13	nfix	nfix	NOUN
bam-7218	280	14	is	be	AUX
bam-7218	280	15	necessary	necessary	ADJ
bam-7218	280	16	for	for	ADP
bam-7218	280	17	both	both	DET
bam-7218	280	18	processes	process	NOUN
bam-7218	280	19	.	.	PUNCT
bam-7218	281	1	during	during	ADP
bam-7218	281	2	muscle	muscle	NOUN
bam-7218	281	3	development	development	NOUN
bam-7218	281	4	,	,	PUNCT
bam-7218	281	5	nfix	nfix	NOUN
bam-7218	281	6	is	be	AUX
bam-7218	281	7	expressed	express	VERB
bam-7218	281	8	by	by	ADP
bam-7218	281	9	fetal	fetal	ADJ
bam-7218	281	10	myoblasts	myoblast	NOUN
bam-7218	281	11	and	and	CCONJ
bam-7218	281	12	regulates	regulate	VERB
bam-7218	281	13	the	the	DET
bam-7218	281	14	switch	switch	NOUN
bam-7218	281	15	from	from	ADP
bam-7218	281	16	embryonic	embryonic	ADJ
bam-7218	281	17	to	to	ADP
bam-7218	281	18	fetal	fetal	ADJ
bam-7218	281	19	myogenesis	myogenesis	NOUN
bam-7218	281	20	by	by	ADP
bam-7218	281	21	activating	activate	VERB
bam-7218	281	22	or	or	CCONJ
bam-7218	281	23	repressing	repress	VERB
bam-7218	281	24	specific	specific	ADJ
bam-7218	281	25	myogenic	myogenic	ADJ
bam-7218	281	26	genes	gene	NOUN
bam-7218	281	27	.	.	PUNCT
bam-7218	282	1	in	in	ADP
bam-7218	282	2	post	post	ADJ
bam-7218	282	3	-	-	ADJ
bam-7218	282	4	natal	natal	ADJ
bam-7218	282	5	life	life	NOUN
bam-7218	282	6	,	,	PUNCT
bam-7218	282	7	nfix	nfix	NOUN
bam-7218	282	8	is	be	AUX
bam-7218	282	9	expressed	express	VERB
bam-7218	282	10	by	by	ADP
bam-7218	282	11	satellite	satellite	NOUN
bam-7218	282	12	cells	cell	NOUN
bam-7218	282	13	(	(	PUNCT
bam-7218	282	14	scs	scs	PROPN
bam-7218	282	15	)	)	PUNCT
bam-7218	282	16	regulating	regulate	VERB
bam-7218	282	17	the	the	DET
bam-7218	282	18	proper	proper	ADJ
bam-7218	282	19	timing	timing	NOUN
bam-7218	282	20	of	of	ADP
bam-7218	282	21	muscle	muscle	NOUN
bam-7218	282	22	regeneration	regeneration	NOUN
bam-7218	282	23	upon	upon	SCONJ
bam-7218	282	24	injury	injury	NOUN
bam-7218	282	25	.	.	PUNCT
bam-7218	283	1	interestingly	interestingly	ADV
bam-7218	283	2	,	,	PUNCT
bam-7218	283	3	not	not	PART
bam-7218	283	4	only	only	ADV
bam-7218	283	5	scs	scs	PROPN
bam-7218	283	6	but	but	CCONJ
bam-7218	283	7	also	also	ADV
bam-7218	283	8	macrophages	macrophage	NOUN
bam-7218	283	9	(	(	PUNCT
bam-7218	283	10	mps	mp	NOUN
bam-7218	283	11	)	)	PUNCT
bam-7218	283	12	express	express	VERB
bam-7218	283	13	nfix	nfix	NOUN
bam-7218	283	14	.	.	PUNCT
bam-7218	284	1	nfix	nfix	NOUN
bam-7218	284	2	is	be	AUX
bam-7218	284	3	expressed	express	VERB
bam-7218	284	4	by	by	ADP
bam-7218	284	5	mps	mp	NOUN
bam-7218	284	6	at	at	ADP
bam-7218	284	7	the	the	DET
bam-7218	284	8	later	later	ADJ
bam-7218	284	9	stages	stage	NOUN
bam-7218	284	10	of	of	ADP
bam-7218	284	11	muscle	muscle	NOUN
bam-7218	284	12	regeneration	regeneration	NOUN
bam-7218	284	13	.	.	PUNCT
bam-7218	285	1	specifically	specifically	ADV
bam-7218	285	2	,	,	PUNCT
bam-7218	285	3	ly6c+	ly6c+	PROPN
bam-7218	285	4	proinflammatory	proinflammatory	ADJ
bam-7218	285	5	mps	mp	NOUN
bam-7218	285	6	exhibit	exhibit	VERB
bam-7218	285	7	the	the	DET
bam-7218	285	8	same	same	ADJ
bam-7218	285	9	level	level	NOUN
bam-7218	285	10	of	of	ADP
bam-7218	285	11	nfix	nfix	NOUN
bam-7218	285	12	while	while	SCONJ
bam-7218	285	13	the	the	DET
bam-7218	285	14	percentage	percentage	NOUN
bam-7218	285	15	of	of	ADP
bam-7218	285	16	nfix+	nfix+	ADP
bam-7218	285	17	ly6canti	ly6canti	ADJ
bam-7218	285	18	-	-	ADJ
bam-7218	285	19	inflammatory	inflammatory	ADJ
bam-7218	285	20	mps	mp	NOUN
bam-7218	285	21	always	always	ADV
bam-7218	285	22	increases	increase	VERB
bam-7218	285	23	over	over	ADP
bam-7218	285	24	the	the	DET
bam-7218	285	25	time	time	NOUN
bam-7218	285	26	during	during	ADP
bam-7218	285	27	regeneration	regeneration	NOUN
bam-7218	285	28	.	.	PUNCT
bam-7218	286	1	since	since	SCONJ
bam-7218	286	2	scs	scs	PROPN
bam-7218	286	3	also	also	ADV
bam-7218	286	4	express	express	VERB
bam-7218	286	5	nfix	nfix	NOUN
bam-7218	286	6	,	,	PUNCT
bam-7218	286	7	we	we	PRON
bam-7218	286	8	generated	generate	VERB
bam-7218	286	9	lysmcre	lysmcre	NOUN
bam-7218	286	10	:	:	PUNCT
bam-7218	286	11	nfixfl	nfixfl	PROPN
bam-7218	286	12	/	/	SYM
bam-7218	286	13	fl	fl	NUM
bam-7218	286	14	mice	mouse	NOUN
bam-7218	286	15	which	which	PRON
bam-7218	286	16	selectively	selectively	ADV
bam-7218	286	17	lack	lack	NOUN
bam-7218	286	18	of	of	ADP
bam-7218	286	19	nfix	nfix	NOUN
bam-7218	286	20	in	in	ADP
bam-7218	286	21	mps	mps	PROPN
bam-7218	286	22	.	.	PUNCT
bam-7218	287	1	after	after	ADP
bam-7218	287	2	cardiotoxin	cardiotoxin	NOUN
bam-7218	287	3	injection	injection	NOUN
bam-7218	287	4	,	,	PUNCT
bam-7218	287	5	skeletal	skeletal	ADJ
bam-7218	287	6	muscles	muscle	NOUN
bam-7218	287	7	of	of	ADP
bam-7218	287	8	lysmcre	lysmcre	NOUN
bam-7218	287	9	:	:	PUNCT
bam-7218	287	10	nfixfl	nfixfl	PROPN
bam-7218	287	11	/	/	SYM
bam-7218	287	12	fl	fl	PROPN
bam-7218	287	13	mice	mouse	NOUN
bam-7218	287	14	exhibit	exhibit	VERB
bam-7218	287	15	a	a	DET
bam-7218	287	16	delay	delay	NOUN
bam-7218	287	17	of	of	ADP
bam-7218	287	18	regeneration	regeneration	NOUN
bam-7218	287	19	characterized	characterize	VERB
bam-7218	287	20	by	by	ADP
bam-7218	287	21	a	a	DET
bam-7218	287	22	persistence	persistence	NOUN
bam-7218	287	23	of	of	ADP
bam-7218	287	24	necrotic	necrotic	ADJ
bam-7218	287	25	myofibers	myofiber	NOUN
bam-7218	287	26	and	and	CCONJ
bam-7218	287	27	a	a	DET
bam-7218	287	28	later	later	ADJ
bam-7218	287	29	appearance	appearance	NOUN
bam-7218	287	30	of	of	ADP
bam-7218	287	31	newly	newly	ADV
bam-7218	287	32	-	-	PUNCT
bam-7218	287	33	formed	form	VERB
bam-7218	287	34	myofibers	myofiber	NOUN
bam-7218	287	35	.	.	PUNCT
bam-7218	288	1	in	in	ADP
bam-7218	288	2	vitro	vitro	X
bam-7218	288	3	,	,	PUNCT
bam-7218	288	4	nfix	nfix	NOUN
bam-7218	288	5	silencing	silence	VERB
bam-7218	288	6	leads	lead	VERB
bam-7218	288	7	to	to	ADP
bam-7218	288	8	a	a	DET
bam-7218	288	9	defect	defect	NOUN
bam-7218	288	10	of	of	ADP
bam-7218	288	11	anti	anti	ADJ
bam-7218	288	12	-	-	ADJ
bam-7218	288	13	inflammatory	inflammatory	ADJ
bam-7218	288	14	phenotype	phenotype	NOUN
bam-7218	288	15	acquisition	acquisition	NOUN
bam-7218	288	16	and	and	CCONJ
bam-7218	288	17	it	it	PRON
bam-7218	288	18	maintains	maintain	VERB
bam-7218	288	19	a	a	DET
bam-7218	288	20	proinflammatory	proinflammatory	ADJ
bam-7218	288	21	phenotype	phenotype	NOUN
bam-7218	288	22	upon	upon	SCONJ
bam-7218	288	23	m2	m2	PROPN
bam-7218	288	24	polarization	polarization	NOUN
bam-7218	288	25	.	.	PUNCT
bam-7218	289	1	functional	functional	ADJ
bam-7218	289	2	experiments	experiment	NOUN
bam-7218	289	3	on	on	ADP
bam-7218	289	4	myoblasts	myoblast	NOUN
bam-7218	289	5	shown	show	VERB
bam-7218	289	6	that	that	SCONJ
bam-7218	289	7	lysmcre	lysmcre	NOUN
bam-7218	289	8	:	:	PUNCT
bam-7218	289	9	nfixfl	nfixfl	PROPN
bam-7218	289	10	/	/	SYM
bam-7218	289	11	fl	fl	PROPN
bam-7218	289	12	m2	m2	PROPN
bam-7218	289	13	mps	mps	PROPN
bam-7218	289	14	adopt	adopt	VERB
bam-7218	289	15	wt	wt	PROPN
bam-7218	289	16	m1	m1	PROPN
bam-7218	289	17	features	feature	NOUN
bam-7218	289	18	.	.	PUNCT
bam-7218	290	1	moreover	moreover	ADV
bam-7218	290	2	,	,	PUNCT
bam-7218	290	3	we	we	PRON
bam-7218	290	4	observed	observe	VERB
bam-7218	290	5	that	that	SCONJ
bam-7218	290	6	mps	mps	PROPN
bam-7218	290	7	failed	fail	VERB
bam-7218	290	8	to	to	PART
bam-7218	290	9	switch	switch	VERB
bam-7218	290	10	from	from	ADP
bam-7218	290	11	proto	proto	NOUN
bam-7218	290	12	anti	anti	ADJ
bam-7218	290	13	-	-	ADJ
bam-7218	290	14	inflammatory	inflammatory	ADJ
bam-7218	290	15	phenotype	phenotype	NOUN
bam-7218	290	16	in	in	ADP
bam-7218	290	17	vivo	vivo	NOUN
bam-7218	290	18	.	.	PUNCT
bam-7218	291	1	dystrophies	dystrophy	NOUN
bam-7218	291	2	are	be	AUX
bam-7218	291	3	genetic	genetic	ADJ
bam-7218	291	4	muscle	muscle	NOUN
bam-7218	291	5	diseases	disease	NOUN
bam-7218	291	6	characterized	characterize	VERB
bam-7218	291	7	by	by	ADP
bam-7218	291	8	continuous	continuous	ADJ
bam-7218	291	9	cycles	cycle	NOUN
bam-7218	291	10	of	of	ADP
bam-7218	291	11	regeneration	regeneration	NOUN
bam-7218	291	12	-	-	PUNCT
bam-7218	291	13	degeneration	degeneration	NOUN
bam-7218	291	14	,	,	PUNCT
bam-7218	291	15	leading	lead	VERB
bam-7218	291	16	to	to	ADP
bam-7218	291	17	exhaustion	exhaustion	NOUN
bam-7218	291	18	of	of	ADP
bam-7218	291	19	scs	scs	NOUN
bam-7218	291	20	pool	pool	NOUN
bam-7218	291	21	and	and	CCONJ
bam-7218	291	22	inflammation	inflammation	NOUN
bam-7218	291	23	.	.	PUNCT
bam-7218	292	1	the	the	DET
bam-7218	292	2	high	high	ADJ
bam-7218	292	3	amount	amount	NOUN
bam-7218	292	4	of	of	ADP
bam-7218	292	5	mps	mps	PROPN
bam-7218	292	6	infiltration	infiltration	NOUN
bam-7218	292	7	is	be	AUX
bam-7218	292	8	linked	link	VERB
bam-7218	292	9	to	to	ADP
bam-7218	292	10	fibrosis	fibrosis	NOUN
bam-7218	292	11	establishment	establishment	NOUN
bam-7218	292	12	.	.	PUNCT
bam-7218	293	1	interestingly	interestingly	ADV
bam-7218	293	2	,	,	PUNCT
bam-7218	293	3	we	we	PRON
bam-7218	293	4	observed	observe	VERB
bam-7218	293	5	in	in	ADP
bam-7218	293	6	two	two	NUM
bam-7218	293	7	models	model	NOUN
bam-7218	293	8	of	of	ADP
bam-7218	293	9	dystrophic	dystrophic	ADJ
bam-7218	293	10	mice	mouse	NOUN
bam-7218	293	11	(	(	PUNCT
bam-7218	293	12	sgca	sgca	NOUN
bam-7218	293	13	null	null	NOUN
bam-7218	293	14	and	and	CCONJ
bam-7218	293	15	mdx	mdx	NOUN
bam-7218	293	16	)	)	PUNCT
bam-7218	293	17	that	that	SCONJ
bam-7218	293	18	the	the	DET
bam-7218	293	19	number	number	NOUN
bam-7218	293	20	of	of	ADP
bam-7218	293	21	mps	mp	NOUN
bam-7218	293	22	positive	positive	ADJ
bam-7218	293	23	for	for	ADP
bam-7218	293	24	nfix	nfix	NOUN
bam-7218	293	25	increases	increase	NOUN
bam-7218	293	26	with	with	ADP
bam-7218	293	27	the	the	DET
bam-7218	293	28	progression	progression	NOUN
bam-7218	293	29	of	of	ADP
bam-7218	293	30	the	the	DET
bam-7218	293	31	disease	disease	NOUN
bam-7218	293	32	.	.	PUNCT
bam-7218	294	1	with	with	ADP
bam-7218	294	2	these	these	DET
bam-7218	294	3	studies	study	NOUN
bam-7218	294	4	,	,	PUNCT
bam-7218	294	5	we	we	PRON
bam-7218	294	6	are	be	AUX
bam-7218	294	7	identifying	identify	VERB
bam-7218	294	8	nfix	nfix	NOUN
bam-7218	294	9	as	as	ADP
bam-7218	294	10	a	a	DET
bam-7218	294	11	necessary	necessary	ADJ
bam-7218	294	12	new	new	ADJ
bam-7218	294	13	interplayer	interplayer	NOUN
bam-7218	294	14	for	for	ADP
bam-7218	294	15	mps	mp	NOUN
bam-7218	294	16	identity	identity	NOUN
bam-7218	294	17	and	and	CCONJ
bam-7218	294	18	function	function	NOUN
bam-7218	294	19	during	during	ADP
bam-7218	294	20	acute	acute	ADJ
bam-7218	294	21	muscle	muscle	NOUN
bam-7218	294	22	regenerative	regenerative	ADJ
bam-7218	294	23	process	process	NOUN
bam-7218	294	24	,	,	PUNCT
bam-7218	294	25	while	while	SCONJ
bam-7218	294	26	nfix	nfix	NOUN
bam-7218	294	27	seems	seem	VERB
bam-7218	294	28	deleterious	deleterious	ADJ
bam-7218	294	29	in	in	ADP
bam-7218	294	30	chronic	chronic	ADJ
bam-7218	294	31	dystrophic	dystrophic	ADJ
bam-7218	294	32	context	context	NOUN
bam-7218	294	33	.	.	PUNCT
bam-7218	295	1	1.8	1.8	NUM
bam-7218	295	2	signaling	signal	VERB
bam-7218	295	3	pathways	pathway	NOUN
bam-7218	295	4	controlling	control	VERB
bam-7218	295	5	nfix	nfix	NOUN
bam-7218	295	6	expression	expression	NOUN
bam-7218	295	7	in	in	ADP
bam-7218	295	8	prenatal	prenatal	ADJ
bam-7218	295	9	and	and	CCONJ
bam-7218	295	10	postnatal	postnatal	ADJ
bam-7218	295	11	skeletal	skeletal	ADJ
bam-7218	295	12	muscle	muscle	NOUN
bam-7218	295	13	progenitors	progenitor	NOUN
bam-7218	295	14	valentina	valentina	PROPN
bam-7218	295	15	taglietti	taglietti	PROPN
bam-7218	295	16	,	,	PUNCT
bam-7218	295	17	stefania	stefania	PROPN
bam-7218	295	18	monteverde	monteverde	PROPN
bam-7218	295	19	,	,	PUNCT
bam-7218	295	20	chiara	chiara	PROPN
bam-7218	295	21	bonfanti	bonfanti	PROPN
bam-7218	295	22	,	,	PUNCT
bam-7218	295	23	graziella	graziella	PROPN
bam-7218	295	24	messina	messina	PROPN
bam-7218	295	25	dept	dept	PROPN
bam-7218	295	26	of	of	ADP
bam-7218	295	27	biosciences	bioscience	NOUN
bam-7218	295	28	,	,	PUNCT
bam-7218	295	29	university	university	NOUN
bam-7218	295	30	of	of	ADP
bam-7218	295	31	milano	milano	PROPN
bam-7218	295	32	,	,	PUNCT
bam-7218	295	33	italy	italy	PROPN
bam-7218	295	34	.	.	PUNCT
bam-7218	296	1	e	e	X
bam-7218	296	2	-	-	NOUN
bam-7218	296	3	mail	mail	NOUN
bam-7218	296	4	:	:	PUNCT
bam-7218	296	5	valentina.taglietti@unimi.it	valentina.taglietti@unimi.it	NOUN
bam-7218	296	6	the	the	DET
bam-7218	296	7	transition	transition	NOUN
bam-7218	296	8	from	from	ADP
bam-7218	296	9	embryonic	embryonic	ADJ
bam-7218	296	10	to	to	ADP
bam-7218	296	11	fetal	fetal	ADJ
bam-7218	296	12	myogenesis	myogenesis	NOUN
bam-7218	296	13	is	be	AUX
bam-7218	296	14	a	a	DET
bam-7218	296	15	crucial	crucial	ADJ
bam-7218	296	16	switch	switch	NOUN
bam-7218	296	17	,	,	PUNCT
bam-7218	296	18	required	require	VERB
bam-7218	296	19	for	for	ADP
bam-7218	296	20	the	the	DET
bam-7218	296	21	complete	complete	ADJ
bam-7218	296	22	maturation	maturation	NOUN
bam-7218	296	23	of	of	ADP
bam-7218	296	24	skeletal	skeletal	ADJ
bam-7218	296	25	muscle	muscle	NOUN
bam-7218	296	26	.	.	PUNCT
bam-7218	297	1	the	the	DET
bam-7218	297	2	transcription	transcription	NOUN
bam-7218	297	3	factor	factor	NOUN
bam-7218	297	4	nfix	nfix	NOUN
bam-7218	297	5	,	,	PUNCT
bam-7218	297	6	specifically	specifically	ADV
bam-7218	297	7	expressed	express	VERB
bam-7218	297	8	during	during	ADP
bam-7218	297	9	fetal	fetal	ADJ
bam-7218	297	10	myogenesis	myogenesis	NOUN
bam-7218	297	11	,	,	PUNCT
bam-7218	297	12	is	be	AUX
bam-7218	297	13	the	the	DET
bam-7218	297	14	master	master	NOUN
bam-7218	297	15	regulator	regulator	NOUN
bam-7218	297	16	of	of	ADP
bam-7218	297	17	this	this	DET
bam-7218	297	18	transition	transition	NOUN
bam-7218	297	19	.	.	PUNCT
bam-7218	298	1	here	here	ADV
bam-7218	298	2	,	,	PUNCT
bam-7218	298	3	we	we	PRON
bam-7218	298	4	show	show	VERB
bam-7218	298	5	that	that	SCONJ
bam-7218	298	6	the	the	DET
bam-7218	298	7	temporal	temporal	ADJ
bam-7218	298	8	progression	progression	NOUN
bam-7218	298	9	of	of	ADP
bam-7218	298	10	prenatal	prenatal	ADJ
bam-7218	298	11	muscle	muscle	NOUN
bam-7218	298	12	development	development	NOUN
bam-7218	298	13	is	be	AUX
bam-7218	298	14	timed	time	VERB
bam-7218	298	15	by	by	ADP
bam-7218	298	16	the	the	DET
bam-7218	298	17	rhoa	rhoa	PROPN
bam-7218	298	18	/	/	SYM
bam-7218	298	19	rock	rock	NOUN
bam-7218	298	20	axis	axis	NOUN
bam-7218	298	21	,	,	PUNCT
bam-7218	298	22	which	which	PRON
bam-7218	298	23	maintains	maintain	VERB
bam-7218	298	24	the	the	DET
bam-7218	298	25	embryonic	embryonic	ADJ
bam-7218	298	26	myogenesis	myogenesis	NOUN
bam-7218	298	27	,	,	PUNCT
bam-7218	298	28	suppressing	suppress	VERB
bam-7218	298	29	nfix	nfix	NOUN
bam-7218	298	30	expression	expression	NOUN
bam-7218	298	31	.	.	PUNCT
bam-7218	299	1	rhoa	rhoa	PROPN
bam-7218	299	2	and	and	CCONJ
bam-7218	299	3	rock	rock	NOUN
bam-7218	299	4	elicit	elicit	VERB
bam-7218	299	5	their	their	PRON
bam-7218	299	6	effects	effect	NOUN
bam-7218	299	7	repressing	repress	VERB
bam-7218	299	8	erk	erk	PROPN
bam-7218	299	9	kinase	kinase	PROPN
bam-7218	299	10	activity	activity	NOUN
bam-7218	299	11	,	,	PUNCT
bam-7218	299	12	which	which	PRON
bam-7218	299	13	instead	instead	ADV
bam-7218	299	14	promotes	promote	VERB
bam-7218	299	15	the	the	DET
bam-7218	299	16	fetal	fetal	ADJ
bam-7218	299	17	genetic	genetic	ADJ
bam-7218	299	18	program	program	NOUN
bam-7218	299	19	.	.	PUNCT
bam-7218	300	1	thus	thus	ADV
bam-7218	300	2	,	,	PUNCT
bam-7218	300	3	rhoa	rhoa	PROPN
bam-7218	300	4	/	/	SYM
bam-7218	300	5	rock	rock	PROPN
bam-7218	300	6	/	/	SYM
bam-7218	300	7	erk	erk	PROPN
bam-7218	300	8	axis	axis	NOUN
bam-7218	300	9	constitutes	constitute	VERB
bam-7218	300	10	one	one	NUM
bam-7218	300	11	of	of	ADP
bam-7218	300	12	the	the	DET
bam-7218	300	13	major	major	ADJ
bam-7218	300	14	pathways	pathway	NOUN
bam-7218	300	15	that	that	PRON
bam-7218	300	16	regulate	regulate	VERB
bam-7218	300	17	the	the	DET
bam-7218	300	18	temporal	temporal	ADJ
bam-7218	300	19	progression	progression	NOUN
bam-7218	300	20	of	of	ADP
bam-7218	300	21	prenatal	prenatal	ADJ
bam-7218	300	22	muscle	muscle	NOUN
bam-7218	300	23	development	development	NOUN
bam-7218	300	24	through	through	ADP
bam-7218	300	25	the	the	DET
bam-7218	300	26	control	control	NOUN
bam-7218	300	27	of	of	ADP
bam-7218	300	28	nfix	nfix	NOUN
bam-7218	300	29	expression	expression	NOUN
bam-7218	300	30	.	.	PUNCT
bam-7218	301	1	rhoa	rhoa	PROPN
bam-7218	301	2	/	/	SYM
bam-7218	301	3	rock	rock	PROPN
bam-7218	301	4	and	and	CCONJ
bam-7218	301	5	erk	erk	NOUN
bam-7218	301	6	signaling	signal	VERB
bam-7218	301	7	pathways	pathway	NOUN
bam-7218	301	8	were	be	AUX
bam-7218	301	9	also	also	ADV
bam-7218	301	10	active	active	ADJ
bam-7218	301	11	in	in	ADP
bam-7218	301	12	the	the	DET
bam-7218	301	13	satellite	satellite	NOUN
bam-7218	301	14	cells	cell	NOUN
bam-7218	301	15	,	,	PUNCT
bam-7218	301	16	the	the	DET
bam-7218	301	17	postnatal	postnatal	ADJ
bam-7218	301	18	population	population	NOUN
bam-7218	301	19	of	of	ADP
bam-7218	301	20	myogenic	myogenic	ADJ
bam-7218	301	21	stem	stem	NOUN
bam-7218	301	22	cells	cell	NOUN
bam-7218	301	23	,	,	PUNCT
bam-7218	301	24	which	which	PRON
bam-7218	301	25	expresses	express	VERB
bam-7218	301	26	high	high	ADJ
bam-7218	301	27	levels	level	NOUN
bam-7218	301	28	of	of	ADP
bam-7218	301	29	nfix	nfix	NOUN
bam-7218	301	30	.	.	PUNCT
bam-7218	302	1	the	the	DET
bam-7218	302	2	modulation	modulation	NOUN
bam-7218	302	3	of	of	ADP
bam-7218	302	4	rhoa	rhoa	PROPN
bam-7218	302	5	and	and	CCONJ
bam-7218	302	6	rock	rock	NOUN
bam-7218	302	7	axis	axis	NOUN
bam-7218	302	8	shows	show	VERB
bam-7218	302	9	that	that	SCONJ
bam-7218	302	10	their	their	PRON
bam-7218	302	11	role	role	NOUN
bam-7218	302	12	,	,	PUNCT
bam-7218	302	13	as	as	ADP
bam-7218	302	14	nfix	nfix	NOUN
bam-7218	302	15	inhibitors	inhibitor	NOUN
bam-7218	302	16	,	,	PUNCT
bam-7218	302	17	is	be	AUX
bam-7218	302	18	not	not	PART
bam-7218	302	19	conserved	conserve	VERB
bam-7218	302	20	in	in	ADP
bam-7218	302	21	satellite	satellite	NOUN
bam-7218	302	22	cells	cell	NOUN
bam-7218	302	23	.	.	PUNCT
bam-7218	303	1	conversely	conversely	ADV
bam-7218	303	2	,	,	PUNCT
bam-7218	303	3	erk	erk	PROPN
bam-7218	303	4	kinases	kinase	NOUN
bam-7218	303	5	activity	activity	NOUN
bam-7218	303	6	is	be	AUX
bam-7218	303	7	necessary	necessary	ADJ
bam-7218	303	8	for	for	ADP
bam-7218	303	9	the	the	DET
bam-7218	303	10	induction	induction	NOUN
bam-7218	303	11	of	of	ADP
bam-7218	303	12	nfix	nfix	NOUN
bam-7218	303	13	expression	expression	NOUN
bam-7218	303	14	not	not	PART
bam-7218	303	15	only	only	ADV
bam-7218	303	16	in	in	ADP
bam-7218	303	17	prenatal	prenatal	ADJ
bam-7218	303	18	fetal	fetal	ADJ
bam-7218	303	19	myoblasts	myoblast	NOUN
bam-7218	303	20	but	but	CCONJ
bam-7218	303	21	also	also	ADV
bam-7218	303	22	in	in	ADP
bam-7218	303	23	satellite	satellite	NOUN
bam-7218	303	24	cells	cell	NOUN
bam-7218	303	25	.	.	PUNCT
bam-7218	304	1	in	in	ADP
bam-7218	304	2	the	the	DET
bam-7218	304	3	light	light	NOUN
bam-7218	304	4	of	of	ADP
bam-7218	304	5	the	the	DET
bam-7218	304	6	fact	fact	NOUN
bam-7218	304	7	that	that	SCONJ
bam-7218	304	8	dystrophic	dystrophic	ADJ
bam-7218	304	9	muscles	muscle	NOUN
bam-7218	304	10	lacking	lack	VERB
bam-7218	304	11	nfix	nfix	NOUN
bam-7218	304	12	have	have	AUX
bam-7218	304	13	a	a	DET
bam-7218	304	14	robust	robust	ADJ
bam-7218	304	15	recovery	recovery	NOUN
bam-7218	304	16	of	of	ADP
bam-7218	304	17	symptoms	symptom	NOUN
bam-7218	304	18	and	and	CCONJ
bam-7218	304	19	muscle	muscle	NOUN
bam-7218	304	20	morphology	morphology	NOUN
bam-7218	304	21	,	,	PUNCT
bam-7218	304	22	our	our	PRON
bam-7218	304	23	results	result	NOUN
bam-7218	304	24	build	build	VERB
bam-7218	304	25	the	the	DET
bam-7218	304	26	basis	basis	NOUN
bam-7218	304	27	of	of	ADP
bam-7218	304	28	a	a	DET
bam-7218	304	29	future	future	ADJ
bam-7218	304	30	therapeutic	therapeutic	ADJ
bam-7218	304	31	approach	approach	NOUN
bam-7218	304	32	for	for	ADP
bam-7218	304	33	muscular	muscular	ADJ
bam-7218	304	34	dystrophies	dystrophy	NOUN
bam-7218	304	35	by	by	ADP
bam-7218	304	36	using	use	VERB
bam-7218	304	37	erk	erk	PROPN
bam-7218	304	38	inhibitors	inhibitor	NOUN
bam-7218	304	39	,	,	PUNCT
bam-7218	304	40	which	which	PRON
bam-7218	304	41	are	be	AUX
bam-7218	304	42	drugs	drug	NOUN
bam-7218	304	43	currently	currently	ADV
bam-7218	304	44	used	use	VERB
bam-7218	304	45	in	in	ADP
bam-7218	304	46	clinic	clinic	NOUN
bam-7218	304	47	for	for	ADP
bam-7218	304	48	the	the	DET
bam-7218	304	49	treatment	treatment	NOUN
bam-7218	304	50	of	of	ADP
bam-7218	304	51	melanoma	melanoma	NOUN
bam-7218	304	52	.	.	PUNCT
bam-7218	305	1	october	october	PROPN
bam-7218	305	2	12	12	NUM
bam-7218	305	3	th	th	NOUN
bam-7218	305	4	session	session	NOUN
bam-7218	305	5	2	2	NUM
bam-7218	305	6	biophysics	biophysic	NOUN
bam-7218	305	7	and	and	CCONJ
bam-7218	305	8	e	e	NOUN
bam-7218	305	9	-	-	NOUN
bam-7218	305	10	c	c	ADJ
bam-7218	305	11	coupling	coupling	NOUN
bam-7218	305	12	in	in	ADP
bam-7218	305	13	the	the	DET
bam-7218	305	14	pathophysiology	pathophysiology	NOUN
bam-7218	305	15	of	of	ADP
bam-7218	305	16	neuromuscular	neuromuscular	ADJ
bam-7218	305	17	diseases	disease	NOUN
bam-7218	305	18	2.1	2.1	NUM
bam-7218	305	19	mechanisms	mechanism	NOUN
bam-7218	305	20	underlying	underlie	VERB
bam-7218	305	21	aerobic	aerobic	ADJ
bam-7218	305	22	training	training	NOUN
bam-7218	305	23	as	as	ADP
bam-7218	305	24	a	a	DET
bam-7218	305	25	strategy	strategy	NOUN
bam-7218	305	26	to	to	PART
bam-7218	305	27	prevent	prevent	VERB
bam-7218	305	28	episodes	episode	NOUN
bam-7218	305	29	related	relate	VERB
bam-7218	305	30	to	to	PART
bam-7218	305	31	heat	heat	VERB
bam-7218	305	32	stress	stress	NOUN
bam-7218	305	33	flávia	flávia	PROPN
bam-7218	305	34	a.	a.	NOUN
bam-7218	305	35	guarnier	guarnier	NOUN
bam-7218	305	36	(	(	PUNCT
bam-7218	305	37	a	a	DET
bam-7218	305	38	,	,	PUNCT
bam-7218	305	39	b	b	NOUN
bam-7218	305	40	)	)	PUNCT
bam-7218	305	41	,	,	PUNCT
bam-7218	305	42	laura	laura	NOUN
bam-7218	305	43	pietrangelo	pietrangelo	PROPN
bam-7218	305	44	(	(	PUNCT
bam-7218	305	45	a	a	X
bam-7218	305	46	)	)	PUNCT
bam-7218	305	47	,	,	PUNCT
bam-7218	305	48	matteo	matteo	PROPN
bam-7218	305	49	serano	serano	PROPN
bam-7218	305	50	(	(	PUNCT
bam-7218	305	51	a	a	NOUN
bam-7218	305	52	)	)	PUNCT
bam-7218	305	53	,	,	PUNCT
bam-7218	305	54	simona	simona	NOUN
bam-7218	305	55	boncompagni	boncompagni	NOUN
bam-7218	305	56	(	(	PUNCT
bam-7218	305	57	a	a	X
bam-7218	305	58	)	)	PUNCT
bam-7218	305	59	,	,	PUNCT
bam-7218	305	60	feliciano	feliciano	PROPN
bam-7218	305	61	protasi	protasi	PROPN
bam-7218	305	62	(	(	PUNCT
bam-7218	305	63	a	a	NOUN
bam-7218	305	64	)	)	PUNCT
bam-7218	305	65	.	.	PUNCT
bam-7218	306	1	(	(	PUNCT
bam-7218	306	2	a	a	X
bam-7218	306	3	)	)	PUNCT
bam-7218	306	4	dept	dept	NOUN
bam-7218	306	5	of	of	ADP
bam-7218	306	6	general	general	ADJ
bam-7218	306	7	pathology	pathology	PROPN
bam-7218	306	8	,	,	PUNCT
bam-7218	306	9	univ	univ	PROPN
bam-7218	306	10	.	.	PUNCT
bam-7218	307	1	estadual	estadual	PROPN
bam-7218	307	2	de	de	PROPN
bam-7218	307	3	londrina	londrina	PROPN
bam-7218	307	4	,	,	PUNCT
bam-7218	307	5	londrina	londrina	PROPN
bam-7218	307	6	,	,	PUNCT
bam-7218	307	7	pr	pr	NOUN
bam-7218	307	8	,	,	PUNCT
bam-7218	307	9	brazil	brazil	PROPN
bam-7218	307	10	;	;	PUNCT
bam-7218	307	11	(	(	PUNCT
bam-7218	307	12	b	b	X
bam-7218	307	13	)	)	PUNCT
bam-7218	307	14	cesi	cesi	PROPN
bam-7218	307	15	-	-	PUNCT
bam-7218	307	16	met	meet	VERB
bam-7218	307	17	,	,	PUNCT
bam-7218	307	18	center	center	NOUN
bam-7218	307	19	for	for	ADP
bam-7218	307	20	research	research	NOUN
bam-7218	307	21	on	on	ADP
bam-7218	307	22	ageing	age	VERB
bam-7218	307	23	and	and	CCONJ
bam-7218	307	24	translational	translational	ADJ
bam-7218	307	25	medicine	medicine	NOUN
bam-7218	307	26	,	,	PUNCT
bam-7218	307	27	university	university	NOUN
bam-7218	307	28	g.	g.	PROPN
bam-7218	307	29	d'annunzio	d'annunzio	PROPN
bam-7218	307	30	,	,	PUNCT
bam-7218	307	31	chieti	chieti	PROPN
bam-7218	307	32	,	,	PUNCT
bam-7218	307	33	italy	italy	PROPN
bam-7218	307	34	.	.	PUNCT
bam-7218	308	1	e	e	X
bam-7218	308	2	-	-	NOUN
bam-7218	308	3	mail	mail	NOUN
bam-7218	308	4	:	:	PUNCT
bam-7218	308	5	faguarnier@uel.br	faguarnier@uel.br	PROPN
bam-7218	308	6	mailto:marielle.saclier@unimi.it	mailto:marielle.saclier@unimi.it	NOUN
bam-7218	308	7	mailto:valentina.taglietti@unimi.it	mailto:valentina.taglietti@unimi.it	NOUN
bam-7218	308	8	mailto:faguarnier@uel.br	mailto:faguarnier@uel.br	ADJ
bam-7218	308	9	14	14	NUM
bam-7218	308	10	th	th	NUM
bam-7218	308	11	iiim	iiim	NOUN
bam-7218	308	12	meeting	meeting	NOUN
bam-7218	308	13	,	,	PUNCT
bam-7218	308	14	assisi	assisi	PROPN
bam-7218	308	15	,	,	PUNCT
bam-7218	308	16	italy	italy	PROPN
bam-7218	308	17	october	october	PROPN
bam-7218	308	18	12	12	NUM
bam-7218	308	19	-	-	SYM
bam-7218	308	20	15	15	NUM
bam-7218	308	21	2017	2017	NUM
bam-7218	308	22	eur	eur	PROPN
bam-7218	308	23	j	j	PROPN
bam-7218	308	24	transl	transl	PROPN
bam-7218	308	25	myol	myol	ADV
bam-7218	308	26	27	27	NUM
bam-7218	308	27	(	(	PUNCT
bam-7218	308	28	4	4	NUM
bam-7218	308	29	):	):	SYM
bam-7218	308	30	185	185	NUM
bam-7218	308	31	-	-	SYM
bam-7218	308	32	224	224	NUM
bam-7218	308	33	193	193	NUM
bam-7218	308	34	heat	heat	NOUN
bam-7218	308	35	stress	stress	NOUN
bam-7218	308	36	is	be	AUX
bam-7218	308	37	defined	define	VERB
bam-7218	308	38	as	as	ADP
bam-7218	308	39	perceived	perceive	VERB
bam-7218	308	40	discomfort	discomfort	NOUN
bam-7218	308	41	and	and	CCONJ
bam-7218	308	42	physiological	physiological	ADJ
bam-7218	308	43	strain	strain	NOUN
bam-7218	308	44	associated	associate	VERB
bam-7218	308	45	with	with	ADP
bam-7218	308	46	exposure	exposure	NOUN
bam-7218	308	47	to	to	ADP
bam-7218	308	48	a	a	DET
bam-7218	308	49	hot	hot	ADJ
bam-7218	308	50	environment	environment	NOUN
bam-7218	308	51	especially	especially	ADV
bam-7218	308	52	during	during	ADP
bam-7218	308	53	physical	physical	ADJ
bam-7218	308	54	work	work	NOUN
bam-7218	308	55	.	.	PUNCT
bam-7218	309	1	in	in	ADP
bam-7218	309	2	2009	2009	NUM
bam-7218	309	3	,	,	PUNCT
bam-7218	309	4	dainese	dainese	PROPN
bam-7218	309	5	and	and	CCONJ
bam-7218	309	6	colleagues	colleague	NOUN
bam-7218	309	7	demonstrated	demonstrate	VERB
bam-7218	309	8	that	that	SCONJ
bam-7218	309	9	mice	mouse	NOUN
bam-7218	309	10	lacking	lack	VERB
bam-7218	309	11	calsequestrin	calsequestrin	PROPN
bam-7218	309	12	1	1	NUM
bam-7218	309	13	knockout	knockout	NOUN
bam-7218	309	14	(	(	PUNCT
bam-7218	309	15	casq1	casq1	NOUN
bam-7218	309	16	-	-	PUNCT
bam-7218	309	17	null	null	NOUN
bam-7218	309	18	)	)	PUNCT
bam-7218	309	19	suffer	suffer	VERB
bam-7218	309	20	lethal	lethal	ADJ
bam-7218	309	21	episodes	episode	NOUN
bam-7218	309	22	when	when	SCONJ
bam-7218	309	23	exposed	expose	VERB
bam-7218	309	24	to	to	ADP
bam-7218	309	25	high	high	ADJ
bam-7218	309	26	environmental	environmental	ADJ
bam-7218	309	27	heat	heat	NOUN
bam-7218	309	28	(	(	PUNCT
bam-7218	309	29	i.e.	i.e.	X
bam-7218	309	30	heat	heat	NOUN
bam-7218	309	31	strokes	stroke	NOUN
bam-7218	309	32	)	)	PUNCT
bam-7218	309	33	(	(	PUNCT
bam-7218	309	34	dainese	dainese	PROPN
bam-7218	309	35	et	et	PROPN
bam-7218	309	36	al	al	PROPN
bam-7218	309	37	.	.	PROPN
bam-7218	309	38	2009	2009	NUM
bam-7218	309	39	)	)	PUNCT
bam-7218	309	40	.	.	PUNCT
bam-7218	310	1	more	more	ADV
bam-7218	310	2	recently	recently	ADV
bam-7218	310	3	,	,	PUNCT
bam-7218	310	4	a	a	DET
bam-7218	310	5	link	link	NOUN
bam-7218	310	6	between	between	ADP
bam-7218	310	7	hyperthermic	hyperthermic	ADJ
bam-7218	310	8	episodes	episode	NOUN
bam-7218	310	9	and	and	CCONJ
bam-7218	310	10	excessive	excessive	ADJ
bam-7218	310	11	oxidative	oxidative	ADJ
bam-7218	310	12	stress	stress	NOUN
bam-7218	310	13	has	have	AUX
bam-7218	310	14	been	be	AUX
bam-7218	310	15	established	establish	VERB
bam-7218	310	16	(	(	PUNCT
bam-7218	310	17	michelucci	michelucci	VERB
bam-7218	310	18	et	et	PROPN
bam-7218	310	19	al	al	PROPN
bam-7218	310	20	.	.	PROPN
bam-7218	310	21	2015	2015	NUM
bam-7218	310	22	)	)	PUNCT
bam-7218	310	23	,	,	PUNCT
bam-7218	310	24	finally	finally	ADV
bam-7218	310	25	,	,	PUNCT
bam-7218	310	26	we	we	PRON
bam-7218	310	27	discovered	discover	VERB
bam-7218	310	28	that	that	SCONJ
bam-7218	310	29	crisis	crisis	NOUN
bam-7218	310	30	can	can	AUX
bam-7218	310	31	be	be	AUX
bam-7218	310	32	prevented	prevent	VERB
bam-7218	310	33	by	by	ADP
bam-7218	310	34	aerobic	aerobic	ADJ
bam-7218	310	35	training	training	NOUN
bam-7218	310	36	,	,	PUNCT
bam-7218	310	37	and	and	CCONJ
bam-7218	310	38	that	that	DET
bam-7218	310	39	oxidative	oxidative	ADJ
bam-7218	310	40	stress	stress	NOUN
bam-7218	310	41	is	be	AUX
bam-7218	310	42	decreased	decrease	VERB
bam-7218	310	43	in	in	ADP
bam-7218	310	44	muscles	muscle	NOUN
bam-7218	310	45	of	of	ADP
bam-7218	310	46	mice	mouse	NOUN
bam-7218	310	47	that	that	PRON
bam-7218	310	48	survive	survive	VERB
bam-7218	310	49	from	from	ADP
bam-7218	310	50	heat	heat	NOUN
bam-7218	310	51	exposure	exposure	NOUN
bam-7218	310	52	after	after	ADP
bam-7218	310	53	training	training	NOUN
bam-7218	310	54	(	(	PUNCT
bam-7218	310	55	guarnier	guarnier	X
bam-7218	310	56	et	et	PROPN
bam-7218	310	57	al	al	PROPN
bam-7218	311	1	.	.	PROPN
bam-7218	311	2	iim	iim	PROPN
bam-7218	311	3	2016	2016	NUM
bam-7218	311	4	)	)	PUNCT
bam-7218	311	5	.	.	PUNCT
bam-7218	312	1	however	however	ADV
bam-7218	312	2	,	,	PUNCT
bam-7218	312	3	the	the	DET
bam-7218	312	4	mechanisms	mechanism	NOUN
bam-7218	312	5	underlying	underlie	VERB
bam-7218	312	6	the	the	DET
bam-7218	312	7	protective	protective	ADJ
bam-7218	312	8	effect	effect	NOUN
bam-7218	312	9	of	of	ADP
bam-7218	312	10	aerobic	aerobic	ADJ
bam-7218	312	11	training	training	NOUN
bam-7218	312	12	deserve	deserve	VERB
bam-7218	312	13	additional	additional	ADJ
bam-7218	312	14	investigation	investigation	NOUN
bam-7218	312	15	.	.	PUNCT
bam-7218	313	1	here	here	ADV
bam-7218	313	2	,	,	PUNCT
bam-7218	313	3	c57bl/6	c57bl/6	NOUN
bam-7218	313	4	and	and	CCONJ
bam-7218	313	5	casq1	casq1	PROPN
bam-7218	313	6	-	-	PUNCT
bam-7218	313	7	null	null	ADJ
bam-7218	313	8	male	male	ADJ
bam-7218	313	9	mice	mouse	NOUN
bam-7218	313	10	had	have	VERB
bam-7218	313	11	their	their	PRON
bam-7218	313	12	individual	individual	ADJ
bam-7218	313	13	maximal	maximal	ADJ
bam-7218	313	14	exercise	exercise	NOUN
bam-7218	313	15	capacity	capacity	NOUN
bam-7218	313	16	evaluated	evaluate	VERB
bam-7218	313	17	at	at	ADP
bam-7218	313	18	2	2	NUM
bam-7218	313	19	-	-	SYM
bam-7218	313	20	2.5	2.5	NUM
bam-7218	313	21	months	month	NOUN
bam-7218	313	22	of	of	ADP
bam-7218	313	23	age	age	NOUN
bam-7218	313	24	before	before	ADP
bam-7218	313	25	being	be	AUX
bam-7218	313	26	subjected	subject	VERB
bam-7218	313	27	to	to	ADP
bam-7218	313	28	aerobic	aerobic	ADJ
bam-7218	313	29	training	training	NOUN
bam-7218	313	30	for	for	ADP
bam-7218	313	31	2	2	NUM
bam-7218	313	32	months	month	NOUN
bam-7218	313	33	(	(	PUNCT
bam-7218	313	34	60	60	NUM
bam-7218	313	35	%	%	NOUN
bam-7218	313	36	of	of	ADP
bam-7218	313	37	maximal	maximal	ADJ
bam-7218	313	38	speed	speed	NOUN
bam-7218	313	39	,	,	PUNCT
bam-7218	313	40	5x	5x	NUM
bam-7218	313	41	/	/	SYM
bam-7218	313	42	week	week	NOUN
bam-7218	313	43	)	)	PUNCT
bam-7218	313	44	.	.	PUNCT
bam-7218	314	1	in	in	ADP
bam-7218	314	2	addition	addition	NOUN
bam-7218	314	3	,	,	PUNCT
bam-7218	314	4	groups	group	NOUN
bam-7218	314	5	of	of	ADP
bam-7218	314	6	c57bl/6	c57bl/6	NOUN
bam-7218	314	7	and	and	CCONJ
bam-7218	314	8	casq1	casq1	NOUN
bam-7218	314	9	-	-	NOUN
bam-7218	314	10	null	null	NOUN
bam-7218	314	11	with	with	ADP
bam-7218	314	12	the	the	DET
bam-7218	314	13	same	same	ADJ
bam-7218	314	14	age	age	NOUN
bam-7218	314	15	were	be	AUX
bam-7218	314	16	sacrificed	sacrifice	VERB
bam-7218	314	17	and	and	CCONJ
bam-7218	314	18	muscles	muscle	NOUN
bam-7218	314	19	collected	collect	VERB
bam-7218	314	20	to	to	PART
bam-7218	314	21	evaluate	evaluate	VERB
bam-7218	314	22	mitochondrial	mitochondrial	ADJ
bam-7218	314	23	damage	damage	NOUN
bam-7218	314	24	and	and	CCONJ
bam-7218	314	25	proteolysis	proteolysis	NOUN
bam-7218	314	26	,	,	PUNCT
bam-7218	314	27	and	and	CCONJ
bam-7218	314	28	cytochrome	cytochrome	NOUN
bam-7218	314	29	c	c	NOUN
bam-7218	314	30	and	and	CCONJ
bam-7218	314	31	serca	serca	PROPN
bam-7218	314	32	activities	activity	NOUN
bam-7218	314	33	.	.	PUNCT
bam-7218	315	1	at	at	ADP
bam-7218	315	2	4	4	NUM
bam-7218	315	3	-	-	SYM
bam-7218	315	4	4.5	4.5	NUM
bam-7218	315	5	months	month	NOUN
bam-7218	315	6	of	of	ADP
bam-7218	315	7	age	age	NOUN
bam-7218	315	8	,	,	PUNCT
bam-7218	315	9	controls	control	NOUN
bam-7218	315	10	,	,	PUNCT
bam-7218	315	11	untrained	untrained	ADJ
bam-7218	315	12	and	and	CCONJ
bam-7218	315	13	trained	train	VERB
bam-7218	315	14	mice	mouse	NOUN
bam-7218	315	15	were	be	AUX
bam-7218	315	16	first	first	ADV
bam-7218	315	17	reevaluated	reevaluate	VERB
bam-7218	315	18	:	:	PUNCT
bam-7218	315	19	casq1	casq1	NOUN
bam-7218	315	20	-	-	PUNCT
bam-7218	315	21	null	null	NOUN
bam-7218	315	22	displayed	display	VERB
bam-7218	315	23	a	a	DET
bam-7218	315	24	raised	raise	VERB
bam-7218	315	25	aerobic	aerobic	ADJ
bam-7218	315	26	capacity	capacity	NOUN
bam-7218	315	27	and	and	CCONJ
bam-7218	315	28	,	,	PUNCT
bam-7218	315	29	when	when	SCONJ
bam-7218	315	30	submitted	submit	VERB
bam-7218	315	31	to	to	ADP
bam-7218	315	32	the	the	DET
bam-7218	315	33	heat	heat	NOUN
bam-7218	315	34	stress	stress	NOUN
bam-7218	315	35	protocol	protocol	NOUN
bam-7218	315	36	(	(	PUNCT
bam-7218	315	37	41	41	NUM
bam-7218	315	38	°	°	NUM
bam-7218	315	39	c/1h	c/1h	NUM
bam-7218	315	40	)	)	PUNCT
bam-7218	315	41	,	,	PUNCT
bam-7218	315	42	the	the	DET
bam-7218	315	43	mortality	mortality	NOUN
bam-7218	315	44	rate	rate	NOUN
bam-7218	315	45	of	of	ADP
bam-7218	315	46	trained	train	VERB
bam-7218	315	47	casq1	casq1	PROPN
bam-7218	315	48	-	-	PUNCT
bam-7218	315	49	null	null	NOUN
bam-7218	315	50	was	be	AUX
bam-7218	315	51	greatly	greatly	ADV
bam-7218	315	52	reduced	reduce	VERB
bam-7218	315	53	(	(	PUNCT
bam-7218	315	54	16.6	16.6	NUM
bam-7218	315	55	%	%	NOUN
bam-7218	315	56	)	)	PUNCT
bam-7218	315	57	when	when	SCONJ
bam-7218	315	58	compared	compare	VERB
bam-7218	315	59	to	to	ADP
bam-7218	315	60	untrained	untrained	ADJ
bam-7218	315	61	mice	mouse	NOUN
bam-7218	315	62	(	(	PUNCT
bam-7218	315	63	85.6	85.6	NUM
bam-7218	315	64	%	%	NOUN
bam-7218	315	65	)	)	PUNCT
bam-7218	315	66	.	.	PUNCT
bam-7218	316	1	muscles	muscle	NOUN
bam-7218	316	2	from	from	ADP
bam-7218	316	3	casq1	casq1	NOUN
bam-7218	316	4	-	-	PUNCT
bam-7218	316	5	null	null	ADJ
bam-7218	316	6	mice	mice	NOUN
bam-7218	316	7	that	that	PRON
bam-7218	316	8	survived	survive	VERB
bam-7218	316	9	from	from	ADP
bam-7218	316	10	heat	heat	NOUN
bam-7218	316	11	-	-	PUNCT
bam-7218	316	12	stress	stress	NOUN
bam-7218	316	13	protocol	protocol	NOUN
bam-7218	316	14	revealed	reveal	VERB
bam-7218	316	15	that	that	SCONJ
bam-7218	316	16	aerobic	aerobic	ADJ
bam-7218	316	17	training	training	NOUN
bam-7218	316	18	was	be	AUX
bam-7218	316	19	effective	effective	ADJ
bam-7218	316	20	in	in	ADP
bam-7218	316	21	:	:	PUNCT
bam-7218	316	22	a	a	X
bam-7218	316	23	)	)	PUNCT
bam-7218	316	24	decreasing	decrease	VERB
bam-7218	316	25	mitochondrial	mitochondrial	ADJ
bam-7218	316	26	damage	damage	NOUN
bam-7218	316	27	(	(	PUNCT
bam-7218	316	28	13	13	NUM
bam-7218	316	29	%	%	NOUN
bam-7218	316	30	vs	vs	ADP
bam-7218	316	31	7	7	NUM
bam-7218	316	32	%	%	NOUN
bam-7218	316	33	in	in	ADP
bam-7218	316	34	trained	train	VERB
bam-7218	316	35	mice	mouse	NOUN
bam-7218	316	36	)	)	PUNCT
bam-7218	316	37	;	;	PUNCT
bam-7218	317	1	b	b	X
bam-7218	317	2	)	)	PUNCT
bam-7218	317	3	improving	improve	VERB
bam-7218	317	4	energy	energy	NOUN
bam-7218	317	5	generation	generation	NOUN
bam-7218	317	6	,	,	PUNCT
bam-7218	317	7	by	by	ADP
bam-7218	317	8	increasing	increase	VERB
bam-7218	317	9	cytochrome	cytochrome	NOUN
bam-7218	317	10	c	c	NOUN
bam-7218	317	11	activity	activity	NOUN
bam-7218	317	12	,	,	PUNCT
bam-7218	317	13	while	while	SCONJ
bam-7218	317	14	decreasing	decrease	VERB
bam-7218	317	15	serca	serca	NOUN
bam-7218	317	16	’s	’s	PART
bam-7218	317	17	;	;	PUNCT
bam-7218	317	18	and	and	CCONJ
bam-7218	317	19	finally	finally	ADV
bam-7218	317	20	c	c	AUX
bam-7218	317	21	)	)	PUNCT
bam-7218	317	22	decreasing	decrease	VERB
bam-7218	317	23	calcium	calcium	NOUN
bam-7218	317	24	-	-	PUNCT
bam-7218	317	25	dependent	dependent	ADJ
bam-7218	317	26	proteolytic	proteolytic	ADJ
bam-7218	317	27	activity	activity	NOUN
bam-7218	317	28	.	.	PUNCT
bam-7218	318	1	taken	take	VERB
bam-7218	318	2	together	together	ADV
bam-7218	318	3	,	,	PUNCT
bam-7218	318	4	these	these	DET
bam-7218	318	5	results	result	NOUN
bam-7218	318	6	indicates	indicate	VERB
bam-7218	318	7	that	that	SCONJ
bam-7218	318	8	the	the	DET
bam-7218	318	9	protective	protective	ADJ
bam-7218	318	10	effect	effect	NOUN
bam-7218	318	11	of	of	ADP
bam-7218	318	12	aerobic	aerobic	ADJ
bam-7218	318	13	training	training	NOUN
bam-7218	318	14	against	against	ADP
bam-7218	318	15	heat	heat	NOUN
bam-7218	318	16	strokes	stroke	NOUN
bam-7218	318	17	is	be	AUX
bam-7218	318	18	mediated	mediate	VERB
bam-7218	318	19	by	by	ADP
bam-7218	318	20	reduction	reduction	NOUN
bam-7218	318	21	of	of	ADP
bam-7218	318	22	oxidative	oxidative	ADJ
bam-7218	318	23	stress	stress	NOUN
bam-7218	318	24	which	which	PRON
bam-7218	318	25	,	,	PUNCT
bam-7218	318	26	in	in	ADP
bam-7218	318	27	turn	turn	NOUN
bam-7218	318	28	,	,	PUNCT
bam-7218	318	29	reduces	reduce	VERB
bam-7218	318	30	mitochondrial	mitochondrial	ADJ
bam-7218	318	31	damage	damage	NOUN
bam-7218	318	32	and	and	CCONJ
bam-7218	318	33	proteolysis	proteolysis	NOUN
bam-7218	318	34	and	and	CCONJ
bam-7218	318	35	improves	improve	VERB
bam-7218	318	36	energy	energy	NOUN
bam-7218	318	37	expenditure	expenditure	NOUN
bam-7218	318	38	.	.	PUNCT
bam-7218	319	1	supported	support	VERB
bam-7218	319	2	by	by	ADP
bam-7218	319	3	:	:	PUNCT
bam-7218	319	4	a	a	X
bam-7218	319	5	)	)	PUNCT
bam-7218	319	6	brazilian	brazilian	NOUN
bam-7218	319	7	ciências	ciências	PROPN
bam-7218	319	8	sem	sem	PROPN
bam-7218	319	9	fronteiras	fronteiras	PROPN
bam-7218	319	10	:	:	PUNCT
bam-7218	319	11	cnpq	cnpq	PROPN
bam-7218	319	12	233892/2014	233892/2014	NUM
bam-7218	319	13	-	-	SYM
bam-7218	319	14	1	1	NUM
bam-7218	319	15	to	to	ADP
bam-7218	319	16	fag	fag	NOUN
bam-7218	319	17	;	;	PUNCT
bam-7218	319	18	b	b	X
bam-7218	319	19	)	)	PUNCT
bam-7218	319	20	italian	italian	ADJ
bam-7218	319	21	telethon	telethon	PROPN
bam-7218	319	22	onlus	onlus	PROPN
bam-7218	319	23	foundation	foundation	PROPN
bam-7218	319	24	rome	rome	PROPN
bam-7218	319	25	,	,	PUNCT
bam-7218	319	26	italy	italy	PROPN
bam-7218	319	27	:	:	PUNCT
bam-7218	319	28	ggp13213	ggp13213	PROPN
bam-7218	319	29	to	to	ADP
bam-7218	319	30	fp	fp	PROPN
bam-7218	319	31	;	;	PUNCT
bam-7218	319	32	c	c	X
bam-7218	319	33	)	)	PUNCT
bam-7218	319	34	italian	italian	ADJ
bam-7218	319	35	ministry	ministry	PROPN
bam-7218	319	36	of	of	ADP
bam-7218	319	37	health	health	PROPN
bam-7218	319	38	:	:	PUNCT
bam-7218	319	39	gr-2011	gr-2011	PROPN
bam-7218	319	40	-	-	PUNCT
bam-7218	319	41	02352681	02352681	NUM
bam-7218	319	42	to	to	ADP
bam-7218	319	43	sb	sb	PROPN
bam-7218	319	44	.	.	PROPN
bam-7218	319	45	2.2	2.2	NUM
bam-7218	319	46	exercise	exercise	NOUN
bam-7218	319	47	prevents	prevent	VERB
bam-7218	319	48	formation	formation	NOUN
bam-7218	319	49	of	of	ADP
bam-7218	319	50	tubular	tubular	ADJ
bam-7218	319	51	aggregates	aggregate	NOUN
bam-7218	319	52	in	in	ADP
bam-7218	319	53	ageing	age	VERB
bam-7218	319	54	skeletal	skeletal	ADJ
bam-7218	319	55	muscle	muscle	NOUN
bam-7218	319	56	fibers	fiber	NOUN
bam-7218	319	57	claudia	claudia	NOUN
bam-7218	319	58	pecorai	pecorai	PROPN
bam-7218	319	59	,	,	PUNCT
bam-7218	319	60	antonio	antonio	PROPN
bam-7218	319	61	michelucci	michelucci	PROPN
bam-7218	319	62	,	,	PUNCT
bam-7218	319	63	laura	laura	PROPN
bam-7218	319	64	pietrangelo	pietrangelo	PROPN
bam-7218	319	65	,	,	PUNCT
bam-7218	319	66	feliciano	feliciano	PROPN
bam-7218	319	67	protasi	protasi	PROPN
bam-7218	319	68	,	,	PUNCT
bam-7218	319	69	simona	simona	PROPN
bam-7218	319	70	boncompagni	boncompagni	NOUN
bam-7218	319	71	cesi	cesi	PROPN
bam-7218	319	72	-	-	PUNCT
bam-7218	319	73	met	meet	VERB
bam-7218	319	74	,	,	PUNCT
bam-7218	319	75	center	center	NOUN
bam-7218	319	76	for	for	ADP
bam-7218	319	77	research	research	NOUN
bam-7218	319	78	on	on	ADP
bam-7218	319	79	ageing	age	VERB
bam-7218	319	80	and	and	CCONJ
bam-7218	319	81	translational	translational	ADJ
bam-7218	319	82	medicine	medicine	NOUN
bam-7218	319	83	,	,	PUNCT
bam-7218	319	84	university	university	NOUN
bam-7218	319	85	g.	g.	PROPN
bam-7218	319	86	d'annunzio	d'annunzio	PROPN
bam-7218	319	87	,	,	PUNCT
bam-7218	319	88	chieti	chieti	PROPN
bam-7218	319	89	-	-	PUNCT
bam-7218	319	90	pescara	pescara	PROPN
bam-7218	319	91	,	,	PUNCT
bam-7218	319	92	italy	italy	PROPN
bam-7218	319	93	.	.	PUNCT
bam-7218	320	1	e	e	X
bam-7218	320	2	-	-	NOUN
bam-7218	320	3	mail	mail	NOUN
bam-7218	320	4	:	:	PUNCT
bam-7218	320	5	claudia.pecorai@unich.it	claudia.pecorai@unich.it	NOUN
bam-7218	320	6	tubular	tubular	ADJ
bam-7218	320	7	aggregates	aggregate	NOUN
bam-7218	320	8	(	(	PUNCT
bam-7218	320	9	tas	ta	NOUN
bam-7218	320	10	)	)	PUNCT
bam-7218	320	11	,	,	PUNCT
bam-7218	320	12	ordered	order	VERB
bam-7218	320	13	arrays	array	NOUN
bam-7218	320	14	of	of	ADP
bam-7218	320	15	sarcoplasmic	sarcoplasmic	ADJ
bam-7218	320	16	reticulum	reticulum	NOUN
bam-7218	320	17	(	(	PUNCT
bam-7218	320	18	sr	sr	PROPN
bam-7218	320	19	)	)	PUNCT
bam-7218	320	20	tubes	tube	NOUN
bam-7218	320	21	,	,	PUNCT
bam-7218	320	22	are	be	AUX
bam-7218	320	23	frequently	frequently	ADV
bam-7218	320	24	found	find	VERB
bam-7218	320	25	in	in	ADP
bam-7218	320	26	ageing	age	VERB
bam-7218	320	27	fast	fast	ADJ
bam-7218	320	28	-	-	PUNCT
bam-7218	320	29	twitch	twitch	NOUN
bam-7218	320	30	fibers	fiber	NOUN
bam-7218	320	31	of	of	ADP
bam-7218	320	32	male	male	ADJ
bam-7218	320	33	c57bl6	c57bl6	NOUN
bam-7218	320	34	mice	mouse	NOUN
bam-7218	320	35	.	.	PUNCT
bam-7218	321	1	tas	ta	NOUN
bam-7218	321	2	are	be	AUX
bam-7218	321	3	also	also	ADV
bam-7218	321	4	found	find	VERB
bam-7218	321	5	in	in	ADP
bam-7218	321	6	biopsies	biopsy	NOUN
bam-7218	321	7	from	from	ADP
bam-7218	321	8	patients	patient	NOUN
bam-7218	321	9	affected	affect	VERB
bam-7218	321	10	by	by	ADP
bam-7218	321	11	tubular	tubular	ADJ
bam-7218	321	12	aggregate	aggregate	ADJ
bam-7218	321	13	myopathy	myopathy	ADJ
bam-7218	321	14	(	(	PUNCT
bam-7218	321	15	tam	tam	PROPN
bam-7218	321	16	)	)	PUNCT
bam-7218	321	17	,	,	PUNCT
bam-7218	321	18	a	a	DET
bam-7218	321	19	muscle	muscle	NOUN
bam-7218	321	20	disorder	disorder	NOUN
bam-7218	321	21	linked	link	VERB
bam-7218	321	22	to	to	ADP
bam-7218	321	23	mutations	mutation	NOUN
bam-7218	321	24	in	in	ADP
bam-7218	321	25	stim1	stim1	NOUN
bam-7218	321	26	and	and	CCONJ
bam-7218	321	27	orai1	orai1	PROPN
bam-7218	321	28	,	,	PUNCT
bam-7218	321	29	stim1	stim1	NOUN
bam-7218	321	30	and	and	CCONJ
bam-7218	321	31	orai1	orai1	NOUN
bam-7218	321	32	are	be	AUX
bam-7218	321	33	the	the	DET
bam-7218	321	34	two	two	NUM
bam-7218	321	35	main	main	ADJ
bam-7218	321	36	players	player	NOUN
bam-7218	321	37	in	in	ADP
bam-7218	321	38	store	store	NOUN
bam-7218	321	39	-	-	PUNCT
bam-7218	321	40	operated	operate	VERB
bam-7218	321	41	ca2	ca2	PROPN
bam-7218	321	42	+	+	NOUN
bam-7218	321	43	entry	entry	NOUN
bam-7218	321	44	(	(	PUNCT
bam-7218	321	45	soce	soce	NOUN
bam-7218	321	46	)	)	PUNCT
bam-7218	321	47	,	,	PUNCT
bam-7218	321	48	a	a	DET
bam-7218	321	49	mechanism	mechanism	NOUN
bam-7218	321	50	that	that	PRON
bam-7218	321	51	allows	allow	VERB
bam-7218	321	52	recovery	recovery	NOUN
bam-7218	321	53	of	of	ADP
bam-7218	321	54	extracellular	extracellular	ADJ
bam-7218	321	55	ca2	ca2	PROPN
bam-7218	321	56	+	+	X
bam-7218	321	57	during	during	ADP
bam-7218	321	58	repetitive	repetitive	ADJ
bam-7218	321	59	activity	activity	NOUN
bam-7218	321	60	and	and	CCONJ
bam-7218	321	61	fatigue	fatigue	NOUN
bam-7218	321	62	.	.	PUNCT
bam-7218	322	1	first	first	ADV
bam-7218	322	2	,	,	PUNCT
bam-7218	322	3	we	we	PRON
bam-7218	322	4	investigated	investigate	VERB
bam-7218	322	5	presence	presence	NOUN
bam-7218	322	6	of	of	ADP
bam-7218	322	7	tas	ta	NOUN
bam-7218	322	8	,	,	PUNCT
bam-7218	322	9	expression	expression	NOUN
bam-7218	322	10	and	and	CCONJ
bam-7218	322	11	subcellular	subcellular	ADJ
bam-7218	322	12	localization	localization	NOUN
bam-7218	322	13	of	of	ADP
bam-7218	322	14	stim1	stim1	NOUN
bam-7218	322	15	and	and	CCONJ
bam-7218	322	16	orai1	orai1	PROPN
bam-7218	322	17	,	,	PUNCT
bam-7218	322	18	and	and	CCONJ
bam-7218	322	19	contractile	contractile	NOUN
bam-7218	322	20	force	force	NOUN
bam-7218	322	21	during	during	ADP
bam-7218	322	22	repetitive	repetitive	ADJ
bam-7218	322	23	stimulation	stimulation	NOUN
bam-7218	322	24	in	in	ADP
bam-7218	322	25	edl	edl	PROPN
bam-7218	322	26	muscle	muscle	NOUN
bam-7218	322	27	from	from	ADP
bam-7218	322	28	male	male	ADJ
bam-7218	322	29	adult	adult	NOUN
bam-7218	322	30	(	(	PUNCT
bam-7218	322	31	4	4	NUM
bam-7218	322	32	months	month	NOUN
bam-7218	322	33	)	)	PUNCT
bam-7218	322	34	and	and	CCONJ
bam-7218	322	35	aged	aged	ADJ
bam-7218	322	36	(	(	PUNCT
bam-7218	322	37	24	24	NUM
bam-7218	322	38	months	month	NOUN
bam-7218	322	39	)	)	PUNCT
bam-7218	322	40	mice	mouse	NOUN
bam-7218	322	41	.	.	PUNCT
bam-7218	323	1	while	while	SCONJ
bam-7218	323	2	tas	ta	NOUN
bam-7218	323	3	are	be	AUX
bam-7218	323	4	never	never	ADV
bam-7218	323	5	found	find	VERB
bam-7218	323	6	in	in	ADP
bam-7218	323	7	4	4	NUM
bam-7218	323	8	month	month	NOUN
bam-7218	323	9	old	old	ADJ
bam-7218	323	10	muscle	muscle	NOUN
bam-7218	323	11	,	,	PUNCT
bam-7218	323	12	50	50	NUM
bam-7218	323	13	%	%	NOUN
bam-7218	323	14	of	of	ADP
bam-7218	323	15	fibers	fiber	NOUN
bam-7218	323	16	contains	contain	VERB
bam-7218	323	17	tas	ta	NOUN
bam-7218	323	18	in	in	ADP
bam-7218	323	19	aged	aged	ADJ
bam-7218	323	20	edls	edls	ADJ
bam-7218	323	21	.	.	PUNCT
bam-7218	324	1	furthermore	furthermore	ADV
bam-7218	324	2	,	,	PUNCT
bam-7218	324	3	we	we	PRON
bam-7218	324	4	have	have	AUX
bam-7218	324	5	found	find	VERB
bam-7218	324	6	that	that	SCONJ
bam-7218	324	7	:	:	PUNCT
bam-7218	324	8	i	i	X
bam-7218	324	9	)	)	PUNCT
bam-7218	324	10	ageing	ageing	NOUN
bam-7218	324	11	causes	cause	VERB
bam-7218	324	12	stim1	stim1	NOUN
bam-7218	324	13	and	and	CCONJ
bam-7218	324	14	orai1	orai1	PROPN
bam-7218	324	15	,	,	PUNCT
bam-7218	324	16	to	to	PART
bam-7218	324	17	accumulate	accumulate	VERB
bam-7218	324	18	in	in	ADP
bam-7218	324	19	tas	ta	NOUN
bam-7218	324	20	;	;	PUNCT
bam-7218	324	21	and	and	CCONJ
bam-7218	324	22	ii	ii	X
bam-7218	324	23	)	)	PUNCT
bam-7218	324	24	edl	edl	PROPN
bam-7218	324	25	muscles	muscle	NOUN
bam-7218	324	26	from	from	ADP
bam-7218	324	27	aged	aged	ADJ
bam-7218	324	28	mice	mouse	NOUN
bam-7218	324	29	exhibit	exhibit	VERB
bam-7218	324	30	a	a	DET
bam-7218	324	31	decreased	decrease	VERB
bam-7218	324	32	capability	capability	NOUN
bam-7218	324	33	to	to	PART
bam-7218	324	34	maintain	maintain	VERB
bam-7218	324	35	contractile	contractile	NOUN
bam-7218	324	36	force	force	NOUN
bam-7218	324	37	compared	compare	VERB
bam-7218	324	38	to	to	ADP
bam-7218	324	39	young	young	ADJ
bam-7218	324	40	animals	animal	NOUN
bam-7218	324	41	(	(	PUNCT
bam-7218	324	42	relative	relative	ADJ
bam-7218	324	43	force	force	NOUN
bam-7218	324	44	after	after	ADP
bam-7218	324	45	10	10	NUM
bam-7218	324	46	tetani	tetani	NOUN
bam-7218	324	47	:	:	PUNCT
bam-7218	324	48	55.0±1.9	55.0±1.9	NUM
bam-7218	324	49	%	%	NOUN
bam-7218	324	50	vs.	vs.	ADP
bam-7218	324	51	65.6±3.5	65.6±3.5	NUM
bam-7218	324	52	%	%	NOUN
bam-7218	324	53	)	)	PUNCT
bam-7218	324	54	.	.	PUNCT
bam-7218	325	1	secondly	secondly	ADV
bam-7218	325	2	,	,	PUNCT
bam-7218	325	3	we	we	PRON
bam-7218	325	4	analyzed	analyze	VERB
bam-7218	325	5	edl	edl	PROPN
bam-7218	325	6	muscles	muscle	NOUN
bam-7218	325	7	from	from	ADP
bam-7218	325	8	3	3	NUM
bam-7218	325	9	male	male	ADJ
bam-7218	325	10	mice	mouse	NOUN
bam-7218	325	11	that	that	PRON
bam-7218	325	12	were	be	AUX
bam-7218	325	13	exercised	exercise	VERB
bam-7218	325	14	in	in	ADP
bam-7218	325	15	wheel	wheel	NOUN
bam-7218	325	16	cages	cage	NOUN
bam-7218	325	17	for	for	ADP
bam-7218	325	18	voluntary	voluntary	ADJ
bam-7218	325	19	running	running	NOUN
bam-7218	325	20	for	for	ADP
bam-7218	325	21	15	15	NUM
bam-7218	325	22	months	month	NOUN
bam-7218	325	23	,	,	PUNCT
bam-7218	325	24	from	from	ADP
bam-7218	325	25	9	9	NUM
bam-7218	325	26	up	up	ADP
bam-7218	325	27	to	to	PART
bam-7218	325	28	24	24	NUM
bam-7218	325	29	months	month	NOUN
bam-7218	325	30	of	of	ADP
bam-7218	325	31	age	age	NOUN
bam-7218	325	32	(	(	PUNCT
bam-7218	325	33	each	each	DET
bam-7218	325	34	mouse	mouse	NOUN
bam-7218	325	35	ran	run	VERB
bam-7218	325	36	on	on	ADP
bam-7218	325	37	the	the	DET
bam-7218	325	38	average	average	NOUN
bam-7218	325	39	a	a	DET
bam-7218	325	40	total	total	NOUN
bam-7218	325	41	of	of	ADP
bam-7218	325	42	~396±29	~396±29	NUM
bam-7218	325	43	km	km	NOUN
bam-7218	325	44	)	)	PUNCT
bam-7218	325	45	and	and	CCONJ
bam-7218	325	46	discovered	discover	VERB
bam-7218	325	47	that	that	SCONJ
bam-7218	325	48	:	:	PUNCT
bam-7218	325	49	a	a	X
bam-7218	325	50	)	)	PUNCT
bam-7218	325	51	wheel	wheel	NOUN
bam-7218	325	52	cage	cage	NOUN
bam-7218	325	53	running	run	VERB
bam-7218	325	54	significantly	significantly	ADV
bam-7218	325	55	reduced	reduce	VERB
bam-7218	325	56	formation	formation	NOUN
bam-7218	325	57	of	of	ADP
bam-7218	325	58	tas	ta	NOUN
bam-7218	325	59	,	,	PUNCT
bam-7218	325	60	with	with	ADP
bam-7218	325	61	a	a	DET
bam-7218	325	62	great	great	ADJ
bam-7218	325	63	reduction	reduction	NOUN
bam-7218	325	64	in	in	ADP
bam-7218	325	65	the	the	DET
bam-7218	325	66	percentage	percentage	NOUN
bam-7218	325	67	of	of	ADP
bam-7218	325	68	fibers	fiber	NOUN
bam-7218	325	69	containing	contain	VERB
bam-7218	325	70	tas	ta	NOUN
bam-7218	325	71	(	(	PUNCT
bam-7218	325	72	50	50	NUM
bam-7218	325	73	%	%	NOUN
bam-7218	325	74	vs.	vs.	ADP
bam-7218	325	75	7	7	NUM
bam-7218	325	76	%	%	NOUN
bam-7218	325	77	,	,	PUNCT
bam-7218	325	78	respectively	respectively	ADV
bam-7218	325	79	in	in	ADP
bam-7218	325	80	untrained	untrained	ADJ
bam-7218	325	81	vs.	vs.	CCONJ
bam-7218	325	82	trained	train	VERB
bam-7218	325	83	animals	animal	NOUN
bam-7218	325	84	)	)	PUNCT
bam-7218	325	85	;	;	PUNCT
bam-7218	325	86	b	b	X
bam-7218	325	87	)	)	PUNCT
bam-7218	325	88	edl	edl	PROPN
bam-7218	325	89	muscles	muscle	NOUN
bam-7218	325	90	from	from	ADP
bam-7218	325	91	aged	aged	ADJ
bam-7218	325	92	mice	mouse	NOUN
bam-7218	325	93	trained	train	VERB
bam-7218	325	94	in	in	ADP
bam-7218	325	95	wheel	wheel	NOUN
bam-7218	325	96	cages	cage	NOUN
bam-7218	325	97	exhibit	exhibit	VERB
bam-7218	325	98	an	an	DET
bam-7218	325	99	increased	increase	VERB
bam-7218	325	100	capability	capability	NOUN
bam-7218	325	101	to	to	PART
bam-7218	325	102	maintain	maintain	VERB
bam-7218	325	103	contractile	contractile	NOUN
bam-7218	325	104	force	force	NOUN
bam-7218	325	105	compared	compare	VERB
bam-7218	325	106	to	to	ADP
bam-7218	325	107	untrained	untrained	ADJ
bam-7218	325	108	aged	aged	ADJ
bam-7218	325	109	match	match	NOUN
bam-7218	325	110	animals	animal	NOUN
bam-7218	325	111	(	(	PUNCT
bam-7218	325	112	relative	relative	ADJ
bam-7218	325	113	force	force	NOUN
bam-7218	325	114	after	after	ADP
bam-7218	325	115	10	10	NUM
bam-7218	325	116	tetani	tetani	NOUN
bam-7218	325	117	:	:	PUNCT
bam-7218	325	118	63.1±4.9	63.1±4.9	NUM
bam-7218	325	119	%	%	NOUN
bam-7218	325	120	vs.	vs.	ADP
bam-7218	325	121	55.0±1.9	55.0±1.9	NUM
bam-7218	325	122	%	%	NOUN
bam-7218	325	123	)	)	PUNCT
bam-7218	325	124	.	.	PUNCT
bam-7218	326	1	taken	take	VERB
bam-7218	326	2	together	together	ADV
bam-7218	326	3	these	these	DET
bam-7218	326	4	findings	finding	NOUN
bam-7218	326	5	point	point	VERB
bam-7218	326	6	to	to	ADP
bam-7218	326	7	:	:	PUNCT
bam-7218	326	8	a	a	X
bam-7218	326	9	)	)	PUNCT
bam-7218	326	10	tas	ta	NOUN
bam-7218	326	11	as	as	ADP
bam-7218	326	12	structures	structure	NOUN
bam-7218	326	13	that	that	PRON
bam-7218	326	14	lead	lead	VERB
bam-7218	326	15	to	to	ADP
bam-7218	326	16	dysfunctional	dysfunctional	ADJ
bam-7218	326	17	accumulation	accumulation	NOUN
bam-7218	326	18	of	of	ADP
bam-7218	326	19	stim1	stim1	NOUN
bam-7218	326	20	and	and	CCONJ
bam-7218	326	21	orai1	orai1	NOUN
bam-7218	326	22	in	in	ADP
bam-7218	326	23	inactive	inactive	ADJ
bam-7218	326	24	mice	mouse	NOUN
bam-7218	326	25	;	;	PUNCT
bam-7218	326	26	and	and	CCONJ
bam-7218	326	27	b	b	X
bam-7218	326	28	)	)	PUNCT
bam-7218	326	29	voluntary	voluntary	ADJ
bam-7218	326	30	exercise	exercise	NOUN
bam-7218	326	31	as	as	ADP
bam-7218	326	32	an	an	DET
bam-7218	326	33	effective	effective	ADJ
bam-7218	326	34	measure	measure	NOUN
bam-7218	326	35	to	to	PART
bam-7218	326	36	prevent	prevent	VERB
bam-7218	326	37	formation	formation	NOUN
bam-7218	326	38	of	of	ADP
bam-7218	326	39	tas	ta	NOUN
bam-7218	326	40	and	and	CCONJ
bam-7218	326	41	maintain	maintain	VERB
bam-7218	326	42	a	a	DET
bam-7218	326	43	functional	functional	ADJ
bam-7218	326	44	soce	soce	NOUN
bam-7218	326	45	in	in	ADP
bam-7218	326	46	muscle	muscle	NOUN
bam-7218	326	47	.	.	PUNCT
bam-7218	327	1	2.3	2.3	NUM
bam-7218	327	2	new	new	ADJ
bam-7218	327	3	biomarkers	biomarker	NOUN
bam-7218	327	4	in	in	ADP
bam-7218	327	5	amiotrophyc	amiotrophyc	ADP
bam-7218	327	6	lateral	lateral	ADJ
bam-7218	327	7	sclerosis	sclerosis	NOUN
bam-7218	327	8	etiopathogenesis	etiopathogenesis	NOUN
bam-7218	327	9	:	:	PUNCT
bam-7218	327	10	analysis	analysis	NOUN
bam-7218	327	11	of	of	ADP
bam-7218	327	12	the	the	DET
bam-7218	327	13	biophysical	biophysical	ADJ
bam-7218	327	14	properties	property	NOUN
bam-7218	327	15	and	and	CCONJ
bam-7218	327	16	gene	gene	NOUN
bam-7218	327	17	expression	expression	NOUN
bam-7218	327	18	in	in	ADP
bam-7218	327	19	skeletal	skeletal	ADJ
bam-7218	327	20	muscle	muscle	NOUN
bam-7218	327	21	of	of	ADP
bam-7218	327	22	sod-1	sod-1	ADJ
bam-7218	327	23	mouse	mouse	NOUN
bam-7218	327	24	models	model	NOUN
bam-7218	327	25	and	and	CCONJ
bam-7218	327	26	repurposing	repurpose	VERB
bam-7218	327	27	of	of	ADP
bam-7218	327	28	acetazolamide	acetazolamide	NOUN
bam-7218	327	29	as	as	ADP
bam-7218	327	30	a	a	DET
bam-7218	327	31	new	new	ADJ
bam-7218	327	32	therapeutic	therapeutic	ADJ
bam-7218	327	33	approach	approach	NOUN
bam-7218	327	34	adriano	adriano	PROPN
bam-7218	327	35	fonzino	fonzino	NOUN
bam-7218	327	36	(	(	PUNCT
bam-7218	327	37	a	a	PROPN
bam-7218	327	38	)	)	PUNCT
bam-7218	327	39	,	,	PUNCT
bam-7218	327	40	elena	elena	PROPN
bam-7218	327	41	conte	conte	PROPN
bam-7218	327	42	(	(	PUNCT
bam-7218	327	43	a	a	NOUN
bam-7218	327	44	)	)	PUNCT
bam-7218	327	45	,	,	PUNCT
bam-7218	327	46	giulia	giulia	PROPN
bam-7218	327	47	maria	maria	PROPN
bam-7218	327	48	camerino	camerino	PROPN
bam-7218	327	49	(	(	PUNCT
bam-7218	327	50	a	a	NOUN
bam-7218	327	51	)	)	PUNCT
bam-7218	327	52	,	,	PUNCT
bam-7218	327	53	antonella	antonella	PROPN
bam-7218	327	54	liantonio	liantonio	PROPN
bam-7218	327	55	(	(	PUNCT
bam-7218	327	56	a	a	NOUN
bam-7218	327	57	)	)	PUNCT
bam-7218	327	58	,	,	PUNCT
bam-7218	327	59	michela	michela	PROPN
bam-7218	327	60	de	de	PROPN
bam-7218	327	61	bellis	bellis	PROPN
bam-7218	327	62	(	(	PUNCT
bam-7218	327	63	a	a	NOUN
bam-7218	327	64	)	)	PUNCT
bam-7218	327	65	,	,	PUNCT
bam-7218	327	66	antonietta	antonietta	VERB
bam-7218	327	67	mele	mele	PROPN
bam-7218	327	68	(	(	PUNCT
bam-7218	327	69	a	a	PROPN
bam-7218	327	70	)	)	PUNCT
bam-7218	327	71	,	,	PUNCT
bam-7218	327	72	domenico	domenico	PROPN
bam-7218	327	73	tricarico	tricarico	PROPN
bam-7218	327	74	(	(	PUNCT
bam-7218	327	75	a	a	NOUN
bam-7218	327	76	)	)	PUNCT
bam-7218	327	77	,	,	PUNCT
bam-7218	327	78	gabriella	gabriella	PROPN
bam-7218	327	79	dobrowolny	dobrowolny	PROPN
bam-7218	327	80	(	(	PUNCT
bam-7218	327	81	b	b	NOUN
bam-7218	327	82	)	)	PUNCT
bam-7218	327	83	,	,	PUNCT
bam-7218	327	84	antonio	antonio	PROPN
bam-7218	327	85	musarò	musarò	NOUN
bam-7218	327	86	(	(	PUNCT
bam-7218	327	87	b	b	NOUN
bam-7218	327	88	)	)	PUNCT
bam-7218	327	89	,	,	PUNCT
bam-7218	327	90	sabata	sabata	NOUN
bam-7218	327	91	pierno	pierno	VERB
bam-7218	327	92	(	(	PUNCT
bam-7218	327	93	a	a	NOUN
bam-7218	327	94	)	)	PUNCT
bam-7218	327	95	(	(	PUNCT
bam-7218	327	96	a	a	X
bam-7218	327	97	)	)	PUNCT
bam-7218	327	98	section	section	NOUN
bam-7218	327	99	of	of	ADP
bam-7218	327	100	pharmacology	pharmacology	NOUN
bam-7218	327	101	,	,	PUNCT
bam-7218	327	102	dept	dept	NOUN
bam-7218	327	103	of	of	ADP
bam-7218	327	104	pharmacy	pharmacy	NOUN
bam-7218	327	105	&	&	CCONJ
bam-7218	327	106	drug	drug	NOUN
bam-7218	327	107	sciences	sciences	PROPN
bam-7218	327	108	,	,	PUNCT
bam-7218	327	109	university	university	NOUN
bam-7218	327	110	of	of	ADP
bam-7218	327	111	bari	bari	NOUN
bam-7218	327	112	,	,	PUNCT
bam-7218	327	113	italy	italy	PROPN
bam-7218	327	114	;	;	PUNCT
bam-7218	327	115	(	(	PUNCT
bam-7218	327	116	b	b	X
bam-7218	327	117	)	)	PUNCT
bam-7218	327	118	dahfmounit	dahfmounit	NOUN
bam-7218	327	119	of	of	ADP
bam-7218	327	120	histology	histology	NOUN
bam-7218	327	121	and	and	CCONJ
bam-7218	327	122	medical	medical	ADJ
bam-7218	327	123	embryology	embryology	NOUN
bam-7218	327	124	,	,	PUNCT
bam-7218	327	125	iim	iim	PROPN
bam-7218	327	126	,	,	PUNCT
bam-7218	327	127	sapienza	sapienza	PROPN
bam-7218	327	128	university	university	PROPN
bam-7218	327	129	of	of	ADP
bam-7218	327	130	rome	rome	PROPN
bam-7218	327	131	,	,	PUNCT
bam-7218	327	132	italy	italy	PROPN
bam-7218	327	133	.	.	PUNCT
bam-7218	328	1	email	email	NOUN
bam-7218	328	2	:	:	PUNCT
bam-7218	328	3	sabata.pierno@uniba.it	sabata.pierno@uniba.it	NOUN
bam-7218	328	4	amyotrophic	amyotrophic	ADJ
bam-7218	328	5	lateral	lateral	ADJ
bam-7218	328	6	sclerosis	sclerosis	NOUN
bam-7218	328	7	(	(	PUNCT
bam-7218	328	8	als	als	NOUN
bam-7218	328	9	)	)	PUNCT
bam-7218	328	10	is	be	AUX
bam-7218	328	11	a	a	DET
bam-7218	328	12	progressive	progressive	ADJ
bam-7218	328	13	neurodegenerative	neurodegenerative	ADJ
bam-7218	328	14	disease	disease	NOUN
bam-7218	328	15	characterized	characterize	VERB
bam-7218	328	16	by	by	ADP
bam-7218	328	17	motorneuron	motorneuron	NOUN
bam-7218	328	18	injury	injury	NOUN
bam-7218	328	19	and	and	CCONJ
bam-7218	328	20	skeletal	skeletal	ADJ
bam-7218	328	21	muscle	muscle	NOUN
bam-7218	328	22	atrophy	atrophy	NOUN
bam-7218	328	23	.	.	PUNCT
bam-7218	329	1	transgenic	transgenic	NOUN
bam-7218	329	2	animals	animal	NOUN
bam-7218	329	3	carrying	carry	VERB
bam-7218	329	4	mutations	mutation	NOUN
bam-7218	329	5	in	in	ADP
bam-7218	329	6	the	the	DET
bam-7218	329	7	sod-1	sod-1	ADJ
bam-7218	329	8	gene	gene	NOUN
bam-7218	329	9	develop	develop	VERB
bam-7218	329	10	similar	similar	ADJ
bam-7218	329	11	symptoms	symptom	NOUN
bam-7218	329	12	than	than	ADP
bam-7218	329	13	those	those	PRON
bam-7218	329	14	observed	observe	VERB
bam-7218	329	15	in	in	ADP
bam-7218	329	16	clinic	clinic	NOUN
bam-7218	329	17	.	.	PUNCT
bam-7218	330	1	in	in	ADP
bam-7218	330	2	this	this	DET
bam-7218	330	3	animal	animal	NOUN
bam-7218	330	4	model	model	NOUN
bam-7218	330	5	skeletal	skeletal	ADJ
bam-7218	330	6	muscle	muscle	NOUN
bam-7218	330	7	has	have	AUX
bam-7218	330	8	been	be	AUX
bam-7218	330	9	demonstrated	demonstrate	VERB
bam-7218	330	10	to	to	ADP
bam-7218	330	11	mailto:claudia.pecorai@unich.it	mailto:claudia.pecorai@unich.it	PROPN
bam-7218	330	12	mailto:sabata.pierno@uniba.it	mailto:sabata.pierno@uniba.it	PROPN
bam-7218	330	13	14	14	NUM
bam-7218	330	14	th	th	NOUN
bam-7218	330	15	iiim	iiim	NOUN
bam-7218	330	16	meeting	meeting	NOUN
bam-7218	330	17	,	,	PUNCT
bam-7218	330	18	assisi	assisi	PROPN
bam-7218	330	19	,	,	PUNCT
bam-7218	330	20	italy	italy	PROPN
bam-7218	330	21	october	october	PROPN
bam-7218	330	22	12	12	NUM
bam-7218	330	23	-	-	SYM
bam-7218	330	24	15	15	NUM
bam-7218	330	25	2017	2017	NUM
bam-7218	330	26	eur	eur	PROPN
bam-7218	330	27	j	j	PROPN
bam-7218	330	28	transl	transl	PROPN
bam-7218	330	29	myol	myol	ADV
bam-7218	330	30	27	27	NUM
bam-7218	330	31	(	(	PUNCT
bam-7218	330	32	4	4	NUM
bam-7218	330	33	):	):	SYM
bam-7218	330	34	185	185	NUM
bam-7218	330	35	-	-	SYM
bam-7218	330	36	224	224	NUM
bam-7218	330	37	194	194	NUM
bam-7218	330	38	be	be	AUX
bam-7218	330	39	primarily	primarily	ADV
bam-7218	330	40	involved	involve	VERB
bam-7218	330	41	in	in	ADP
bam-7218	330	42	sod-1	sod-1	ADV
bam-7218	330	43	-	-	PUNCT
bam-7218	330	44	mediated	mediate	VERB
bam-7218	330	45	toxicity	toxicity	NOUN
bam-7218	330	46	(	(	PUNCT
bam-7218	330	47	dobrowolny	dobrowolny	NOUN
bam-7218	330	48	et	et	PROPN
bam-7218	330	49	al	al	PROPN
bam-7218	330	50	.	.	PROPN
bam-7218	330	51	cell	cell	NOUN
bam-7218	330	52	metabolism	metabolism	NOUN
bam-7218	330	53	.	.	PUNCT
bam-7218	331	1	8	8	NUM
bam-7218	331	2	,	,	PUNCT
bam-7218	331	3	425–36	425–36	NUM
bam-7218	331	4	,	,	PUNCT
bam-7218	331	5	2008	2008	NUM
bam-7218	331	6	)	)	PUNCT
bam-7218	331	7	.	.	PUNCT
bam-7218	332	1	in	in	ADP
bam-7218	332	2	this	this	DET
bam-7218	332	3	context	context	NOUN
bam-7218	332	4	,	,	PUNCT
bam-7218	332	5	sarcolemma	sarcolemma	ADJ
bam-7218	332	6	ion	ion	NOUN
bam-7218	332	7	channels	channel	NOUN
bam-7218	332	8	play	play	VERB
bam-7218	332	9	a	a	DET
bam-7218	332	10	crucial	crucial	ADJ
bam-7218	332	11	role	role	NOUN
bam-7218	332	12	for	for	ADP
bam-7218	332	13	muscle	muscle	NOUN
bam-7218	332	14	function	function	NOUN
bam-7218	332	15	.	.	PUNCT
bam-7218	333	1	resting	rest	VERB
bam-7218	333	2	chloride	chloride	NOUN
bam-7218	333	3	conductance	conductance	NOUN
bam-7218	333	4	(	(	PUNCT
bam-7218	333	5	gcl	gcl	NOUN
bam-7218	333	6	)	)	PUNCT
bam-7218	333	7	,	,	PUNCT
bam-7218	333	8	sustained	sustain	VERB
bam-7218	333	9	by	by	ADP
bam-7218	333	10	the	the	DET
bam-7218	333	11	clc-1	clc-1	DET
bam-7218	333	12	channel	channel	NOUN
bam-7218	333	13	,	,	PUNCT
bam-7218	333	14	controls	control	VERB
bam-7218	333	15	sarcolemma	sarcolemma	PROPN
bam-7218	333	16	excitability	excitability	NOUN
bam-7218	333	17	,	,	PUNCT
bam-7218	333	18	indeed	indeed	ADV
bam-7218	333	19	a	a	DET
bam-7218	333	20	large	large	ADJ
bam-7218	333	21	reduction	reduction	NOUN
bam-7218	333	22	of	of	ADP
bam-7218	333	23	gcl	gcl	PROPN
bam-7218	333	24	produces	produce	VERB
bam-7218	333	25	myotonic	myotonic	ADJ
bam-7218	333	26	-	-	PUNCT
bam-7218	333	27	like	like	ADJ
bam-7218	333	28	symptoms	symptom	NOUN
bam-7218	333	29	(	(	PUNCT
bam-7218	333	30	pierno	pierno	VERB
bam-7218	333	31	et	et	PROPN
bam-7218	333	32	al	al	PROPN
bam-7218	333	33	.	.	PROPN
bam-7218	333	34	brain	brain	PROPN
bam-7218	333	35	125	125	NUM
bam-7218	333	36	,	,	PUNCT
bam-7218	333	37	1510–21	1510–21	NUM
bam-7218	333	38	,	,	PUNCT
bam-7218	333	39	2002	2002	NUM
bam-7218	333	40	)	)	PUNCT
bam-7218	333	41	.	.	PUNCT
bam-7218	334	1	at	at	ADP
bam-7218	334	2	the	the	DET
bam-7218	334	3	moment	moment	NOUN
bam-7218	334	4	,	,	PUNCT
bam-7218	334	5	there	there	PRON
bam-7218	334	6	are	be	VERB
bam-7218	334	7	no	no	DET
bam-7218	334	8	data	datum	NOUN
bam-7218	334	9	describing	describe	VERB
bam-7218	334	10	the	the	DET
bam-7218	334	11	involvement	involvement	NOUN
bam-7218	334	12	of	of	ADP
bam-7218	334	13	skeletal	skeletal	ADJ
bam-7218	334	14	muscle	muscle	NOUN
bam-7218	334	15	ion	ion	NOUN
bam-7218	334	16	channels	channel	NOUN
bam-7218	334	17	functions	function	NOUN
bam-7218	334	18	in	in	ADP
bam-7218	334	19	this	this	DET
bam-7218	334	20	pathology	pathology	NOUN
bam-7218	334	21	,	,	PUNCT
bam-7218	334	22	thus	thus	ADV
bam-7218	334	23	,	,	PUNCT
bam-7218	334	24	we	we	PRON
bam-7218	334	25	measured	measure	VERB
bam-7218	334	26	the	the	DET
bam-7218	334	27	resting	rest	VERB
bam-7218	334	28	gcl	gcl	NOUN
bam-7218	334	29	and	and	CCONJ
bam-7218	334	30	the	the	DET
bam-7218	334	31	potassium	potassium	NOUN
bam-7218	334	32	conductance	conductance	NOUN
bam-7218	334	33	(	(	PUNCT
bam-7218	334	34	gk	gk	PROPN
bam-7218	334	35	)	)	PUNCT
bam-7218	334	36	,	,	PUNCT
bam-7218	334	37	as	as	ADV
bam-7218	334	38	well	well	ADV
bam-7218	334	39	as	as	ADP
bam-7218	334	40	muscle	muscle	NOUN
bam-7218	334	41	excitability	excitability	NOUN
bam-7218	334	42	in	in	ADP
bam-7218	334	43	extensor	extensor	PROPN
bam-7218	334	44	digitorum	digitorum	PROPN
bam-7218	334	45	longus	longus	PROPN
bam-7218	334	46	muscle	muscle	NOUN
bam-7218	334	47	of	of	ADP
bam-7218	334	48	4	4	NUM
bam-7218	334	49	-	-	PUNCT
bam-7218	334	50	months	month	NOUN
bam-7218	334	51	old	old	ADJ
bam-7218	334	52	transgenic	transgenic	NOUN
bam-7218	334	53	sod-1	sod-1	ADJ
bam-7218	334	54	mice	mouse	NOUN
bam-7218	334	55	,	,	PUNCT
bam-7218	334	56	at	at	ADP
bam-7218	334	57	the	the	DET
bam-7218	334	58	onset	onset	NOUN
bam-7218	334	59	of	of	ADP
bam-7218	334	60	the	the	DET
bam-7218	334	61	symptoms	symptom	NOUN
bam-7218	334	62	,	,	PUNCT
bam-7218	334	63	by	by	ADP
bam-7218	334	64	using	use	VERB
bam-7218	334	65	the	the	DET
bam-7218	334	66	two	two	NUM
bam-7218	334	67	-	-	PUNCT
bam-7218	334	68	intracellular	intracellular	ADJ
bam-7218	334	69	microelectrodes	microelectrode	NOUN
bam-7218	334	70	technique	technique	NOUN
bam-7218	334	71	.	.	PUNCT
bam-7218	335	1	we	we	PRON
bam-7218	335	2	found	find	VERB
bam-7218	335	3	that	that	SCONJ
bam-7218	335	4	resting	rest	VERB
bam-7218	335	5	gcl	gcl	PROPN
bam-7218	335	6	was	be	AUX
bam-7218	335	7	strongly	strongly	ADV
bam-7218	335	8	reduced	reduce	VERB
bam-7218	335	9	in	in	ADP
bam-7218	335	10	sod-1	sod-1	ADJ
bam-7218	335	11	mice	mouse	NOUN
bam-7218	335	12	as	as	ADP
bam-7218	335	13	compared	compare	VERB
bam-7218	335	14	to	to	ADP
bam-7218	335	15	wild	wild	ADJ
bam-7218	335	16	-	-	PUNCT
bam-7218	335	17	type	type	NOUN
bam-7218	335	18	(	(	PUNCT
bam-7218	335	19	wt	wt	NOUN
bam-7218	335	20	)	)	PUNCT
bam-7218	335	21	,	,	PUNCT
bam-7218	335	22	being	be	AUX
bam-7218	335	23	it	it	PRON
bam-7218	335	24	1593±100	1593±100	INTJ
bam-7218	335	25	µs	µs	X
bam-7218	335	26	/	/	SYM
bam-7218	335	27	cm2	cm2	PROPN
bam-7218	335	28	(	(	PUNCT
bam-7218	335	29	19	19	NUM
bam-7218	335	30	fibers	fiber	NOUN
bam-7218	335	31	)	)	PUNCT
bam-7218	335	32	and	and	CCONJ
bam-7218	335	33	2410±79	2410±79	NOUN
bam-7218	335	34	µs	µs	NOUN
bam-7218	335	35	/	/	SYM
bam-7218	335	36	cm2	cm2	NOUN
bam-7218	335	37	(	(	PUNCT
bam-7218	335	38	22	22	NUM
bam-7218	335	39	fibers	fiber	NOUN
bam-7218	335	40	)	)	PUNCT
bam-7218	335	41	,	,	PUNCT
bam-7218	335	42	respectively	respectively	ADV
bam-7218	335	43	.	.	PUNCT
bam-7218	336	1	resting	rest	VERB
bam-7218	336	2	gk	gk	PROPN
bam-7218	336	3	was	be	AUX
bam-7218	336	4	increased	increase	VERB
bam-7218	336	5	in	in	ADP
bam-7218	336	6	sod-1	sod-1	ADJ
bam-7218	336	7	animals	animal	NOUN
bam-7218	336	8	by	by	ADP
bam-7218	336	9	67±27	67±27	NOUN
bam-7218	336	10	%	%	NOUN
bam-7218	336	11	.	.	PUNCT
bam-7218	337	1	preliminary	preliminary	ADJ
bam-7218	337	2	patch	patch	PROPN
bam-7218	337	3	clamp	clamp	NOUN
bam-7218	337	4	studies	study	NOUN
bam-7218	337	5	showed	show	VERB
bam-7218	337	6	different	different	ADJ
bam-7218	337	7	activity	activity	NOUN
bam-7218	337	8	of	of	ADP
bam-7218	337	9	the	the	DET
bam-7218	337	10	katp	katp	NOUN
bam-7218	337	11	channels	channel	NOUN
bam-7218	337	12	and	and	CCONJ
bam-7218	337	13	an	an	DET
bam-7218	337	14	altered	altered	ADJ
bam-7218	337	15	sensitivity	sensitivity	NOUN
bam-7218	337	16	to	to	PART
bam-7218	337	17	atp	atp	PROPN
bam-7218	337	18	in	in	ADP
bam-7218	337	19	accord	accord	NOUN
bam-7218	337	20	with	with	ADP
bam-7218	337	21	the	the	DET
bam-7218	337	22	increase	increase	NOUN
bam-7218	337	23	of	of	ADP
bam-7218	337	24	gk	gk	PROPN
bam-7218	337	25	.	.	PUNCT
bam-7218	338	1	also	also	ADV
bam-7218	338	2	sarcolemma	sarcolemma	PROPN
bam-7218	338	3	excitability	excitability	NOUN
bam-7218	338	4	,	,	PUNCT
bam-7218	338	5	evaluated	evaluate	VERB
bam-7218	338	6	as	as	ADP
bam-7218	338	7	the	the	DET
bam-7218	338	8	maximum	maximum	ADJ
bam-7218	338	9	number	number	NOUN
bam-7218	338	10	of	of	ADP
bam-7218	338	11	action	action	NOUN
bam-7218	338	12	potentials	potential	NOUN
bam-7218	338	13	,	,	PUNCT
bam-7218	338	14	was	be	AUX
bam-7218	338	15	accordingly	accordingly	ADV
bam-7218	338	16	increased	increase	VERB
bam-7218	338	17	from	from	ADP
bam-7218	338	18	7.1±0.8	7.1±0.8	PROPN
bam-7218	338	19	(	(	PUNCT
bam-7218	338	20	16	16	NUM
bam-7218	338	21	fibers	fiber	NOUN
bam-7218	338	22	)	)	PUNCT
bam-7218	338	23	in	in	ADP
bam-7218	338	24	wt	wt	NUM
bam-7218	338	25	to	to	ADP
bam-7218	338	26	12.6±1.5	12.6±1.5	NUM
bam-7218	338	27	(	(	PUNCT
bam-7218	338	28	10	10	NUM
bam-7218	338	29	fibers	fiber	NOUN
bam-7218	338	30	)	)	PUNCT
bam-7218	338	31	in	in	ADP
bam-7218	338	32	sod-1	sod-1	ADJ
bam-7218	338	33	muscle	muscle	NOUN
bam-7218	338	34	fibers	fiber	NOUN
bam-7218	338	35	.	.	PUNCT
bam-7218	339	1	resting	rest	VERB
bam-7218	339	2	intracellular	intracellular	ADJ
bam-7218	339	3	calcium	calcium	NOUN
bam-7218	339	4	level	level	NOUN
bam-7218	339	5	was	be	AUX
bam-7218	339	6	increased	increase	VERB
bam-7218	339	7	in	in	ADP
bam-7218	339	8	these	these	DET
bam-7218	339	9	animals	animal	NOUN
bam-7218	339	10	and	and	CCONJ
bam-7218	339	11	an	an	DET
bam-7218	339	12	altered	altered	ADJ
bam-7218	339	13	response	response	NOUN
bam-7218	339	14	to	to	ADP
bam-7218	339	15	caffeine	caffeine	NOUN
bam-7218	339	16	was	be	AUX
bam-7218	339	17	found	find	VERB
bam-7218	339	18	.	.	PUNCT
bam-7218	340	1	in	in	ADP
bam-7218	340	2	order	order	NOUN
bam-7218	340	3	to	to	PART
bam-7218	340	4	evaluate	evaluate	VERB
bam-7218	340	5	the	the	DET
bam-7218	340	6	muscular	muscular	ADJ
bam-7218	340	7	involvement	involvement	NOUN
bam-7218	340	8	in	in	ADP
bam-7218	340	9	the	the	DET
bam-7218	340	10	pathology	pathology	NOUN
bam-7218	340	11	we	we	PRON
bam-7218	340	12	also	also	ADV
bam-7218	340	13	examined	examine	VERB
bam-7218	340	14	an	an	DET
bam-7218	340	15	animal	animal	NOUN
bam-7218	340	16	model	model	NOUN
bam-7218	340	17	in	in	ADP
bam-7218	340	18	which	which	PRON
bam-7218	340	19	the	the	DET
bam-7218	340	20	mutated	mutate	VERB
bam-7218	340	21	sod1	sod1	ADJ
bam-7218	340	22	g93a	g93a	NOUN
bam-7218	340	23	gene	gene	NOUN
bam-7218	340	24	is	be	AUX
bam-7218	340	25	selectively	selectively	ADV
bam-7218	340	26	overexpressed	overexpresse	VERB
bam-7218	340	27	in	in	ADP
bam-7218	340	28	skeletal	skeletal	ADJ
bam-7218	340	29	muscle	muscle	NOUN
bam-7218	340	30	under	under	ADP
bam-7218	340	31	the	the	DET
bam-7218	340	32	control	control	NOUN
bam-7218	340	33	of	of	ADP
bam-7218	340	34	the	the	DET
bam-7218	340	35	mlc	mlc	NOUN
bam-7218	340	36	promoter	promoter	NOUN
bam-7218	340	37	.	.	PUNCT
bam-7218	341	1	similar	similar	ADJ
bam-7218	341	2	modifications	modification	NOUN
bam-7218	341	3	were	be	AUX
bam-7218	341	4	found	find	VERB
bam-7218	341	5	in	in	ADP
bam-7218	341	6	skeletal	skeletal	ADJ
bam-7218	341	7	muscle	muscle	NOUN
bam-7218	341	8	of	of	ADP
bam-7218	341	9	these	these	DET
bam-7218	341	10	animals	animal	NOUN
bam-7218	341	11	,	,	PUNCT
bam-7218	341	12	since	since	SCONJ
bam-7218	341	13	resting	rest	VERB
bam-7218	341	14	gcl	gcl	PROPN
bam-7218	341	15	was	be	AUX
bam-7218	341	16	reduced	reduce	VERB
bam-7218	341	17	to	to	ADP
bam-7218	341	18	1694±146	1694±146	NUM
bam-7218	341	19	µs	µs	ADP
bam-7218	341	20	/	/	SYM
bam-7218	341	21	cm2	cm2	NOUN
bam-7218	341	22	(	(	PUNCT
bam-7218	341	23	19	19	NUM
bam-7218	341	24	fibers	fiber	NOUN
bam-7218	341	25	)	)	PUNCT
bam-7218	341	26	.	.	PUNCT
bam-7218	342	1	we	we	PRON
bam-7218	342	2	observed	observe	VERB
bam-7218	342	3	that	that	SCONJ
bam-7218	342	4	the	the	DET
bam-7218	342	5	clc-1	clc-1	DET
bam-7218	342	6	mrna	mrna	NOUN
bam-7218	342	7	expression	expression	NOUN
bam-7218	342	8	was	be	AUX
bam-7218	342	9	significantly	significantly	ADV
bam-7218	342	10	decreased	decrease	VERB
bam-7218	342	11	in	in	ADP
bam-7218	342	12	muscles	muscle	NOUN
bam-7218	342	13	of	of	ADP
bam-7218	342	14	sod-1	sod-1	ADJ
bam-7218	342	15	mice	mouse	NOUN
bam-7218	342	16	respect	respect	NOUN
bam-7218	342	17	to	to	ADP
bam-7218	342	18	wt	wt	PROPN
bam-7218	342	19	but	but	CCONJ
bam-7218	342	20	do	do	AUX
bam-7218	342	21	not	not	PART
bam-7218	342	22	change	change	VERB
bam-7218	342	23	in	in	ADP
bam-7218	342	24	muscles	muscle	NOUN
bam-7218	342	25	of	of	ADP
bam-7218	342	26	mlc	mlc	PROPN
bam-7218	342	27	/	/	SYM
bam-7218	342	28	sod1g93a	sod1g93a	NUM
bam-7218	342	29	mice	mouse	NOUN
bam-7218	342	30	.	.	PUNCT
bam-7218	343	1	in	in	ADP
bam-7218	343	2	this	this	DET
bam-7218	343	3	animal	animal	NOUN
bam-7218	343	4	model	model	NOUN
bam-7218	343	5	we	we	PRON
bam-7218	343	6	tested	test	VERB
bam-7218	343	7	the	the	DET
bam-7218	343	8	in	in	ADV
bam-7218	343	9	vitro	vitro	X
bam-7218	343	10	effect	effect	NOUN
bam-7218	343	11	of	of	ADP
bam-7218	343	12	acetazolamide	acetazolamide	NOUN
bam-7218	343	13	,	,	PUNCT
bam-7218	343	14	previously	previously	ADV
bam-7218	343	15	found	find	VERB
bam-7218	343	16	to	to	PART
bam-7218	343	17	beneficially	beneficially	ADV
bam-7218	343	18	improve	improve	VERB
bam-7218	343	19	clc-1	clc-1	DET
bam-7218	343	20	function	function	NOUN
bam-7218	343	21	in	in	ADP
bam-7218	343	22	myotonia	myotonia	NOUN
bam-7218	343	23	congenita	congenita	NOUN
bam-7218	343	24	through	through	ADP
bam-7218	343	25	voltage	voltage	NOUN
bam-7218	343	26	-	-	PUNCT
bam-7218	343	27	dependence	dependence	NOUN
bam-7218	343	28	regulation	regulation	NOUN
bam-7218	343	29	(	(	PUNCT
bam-7218	343	30	desaphy	desaphy	NOUN
bam-7218	343	31	et	et	PROPN
bam-7218	343	32	al	al	PROPN
bam-7218	343	33	.	.	PUNCT
bam-7218	344	1	exp	exp	PROPN
bam-7218	344	2	neurol	neurol	NOUN
bam-7218	344	3	.	.	PUNCT
bam-7218	345	1	248	248	NUM
bam-7218	345	2	:	:	PUNCT
bam-7218	345	3	530	530	NUM
bam-7218	345	4	-	-	SYM
bam-7218	345	5	40	40	NUM
bam-7218	345	6	,	,	PUNCT
bam-7218	345	7	2013	2013	NUM
bam-7218	345	8	)	)	PUNCT
bam-7218	345	9	.	.	PUNCT
bam-7218	346	1	interestingly	interestingly	ADV
bam-7218	346	2	,	,	PUNCT
bam-7218	346	3	acetazolamide	acetazolamide	NOUN
bam-7218	346	4	application	application	NOUN
bam-7218	346	5	,	,	PUNCT
bam-7218	346	6	increased	increase	VERB
bam-7218	346	7	resting	rest	VERB
bam-7218	346	8	gcl	gcl	NOUN
bam-7218	346	9	toward	toward	ADP
bam-7218	346	10	the	the	DET
bam-7218	346	11	control	control	NOUN
bam-7218	346	12	value	value	NOUN
bam-7218	346	13	,	,	PUNCT
bam-7218	346	14	being	be	AUX
bam-7218	346	15	2097±119	2097±119	NUM
bam-7218	346	16	µs	µs	NOUN
bam-7218	346	17	/	/	SYM
bam-7218	346	18	cm2	cm2	NOUN
bam-7218	346	19	(	(	PUNCT
bam-7218	346	20	19	19	NUM
bam-7218	346	21	fibers	fiber	NOUN
bam-7218	346	22	)	)	PUNCT
bam-7218	346	23	.	.	PUNCT
bam-7218	347	1	accordingly	accordingly	ADV
bam-7218	347	2	,	,	PUNCT
bam-7218	347	3	sarcolemma	sarcolemma	PROPN
bam-7218	347	4	hyperexcitability	hyperexcitability	PROPN
bam-7218	347	5	was	be	AUX
bam-7218	347	6	improved	improve	VERB
bam-7218	347	7	.	.	PUNCT
bam-7218	348	1	in	in	ADP
bam-7218	348	2	conclusion	conclusion	NOUN
bam-7218	348	3	,	,	PUNCT
bam-7218	348	4	chloride	chloride	ADJ
bam-7218	348	5	channel	channel	NOUN
bam-7218	348	6	function	function	NOUN
bam-7218	348	7	is	be	AUX
bam-7218	348	8	modified	modify	VERB
bam-7218	348	9	in	in	ADP
bam-7218	348	10	skeletal	skeletal	ADJ
bam-7218	348	11	muscle	muscle	NOUN
bam-7218	348	12	of	of	ADP
bam-7218	348	13	the	the	DET
bam-7218	348	14	sod-1	sod-1	ADJ
bam-7218	348	15	transgenic	transgenic	NOUN
bam-7218	348	16	animals	animal	NOUN
bam-7218	348	17	suggesting	suggest	VERB
bam-7218	348	18	their	their	PRON
bam-7218	348	19	contribution	contribution	NOUN
bam-7218	348	20	to	to	PART
bam-7218	348	21	als	als	VERB
bam-7218	348	22	and	and	CCONJ
bam-7218	348	23	opens	open	VERB
bam-7218	348	24	the	the	DET
bam-7218	348	25	possibility	possibility	NOUN
bam-7218	348	26	to	to	PART
bam-7218	348	27	investigate	investigate	VERB
bam-7218	348	28	on	on	ADP
bam-7218	348	29	acetazolamide	acetazolamide	ADV
bam-7218	348	30	as	as	ADP
bam-7218	348	31	a	a	DET
bam-7218	348	32	promising	promising	ADJ
bam-7218	348	33	therapy	therapy	NOUN
bam-7218	348	34	.	.	PUNCT
bam-7218	349	1	2.4	2.4	NUM
bam-7218	349	2	physiological	physiological	ADJ
bam-7218	349	3	and	and	CCONJ
bam-7218	349	4	structural	structural	ADJ
bam-7218	349	5	properties	property	NOUN
bam-7218	349	6	of	of	ADP
bam-7218	349	7	the	the	DET
bam-7218	349	8	octopus	octopus	NOUN
bam-7218	349	9	vulgaris	vulgaris	NOUN
bam-7218	349	10	arm	arm	VERB
bam-7218	349	11	hydrostatic	hydrostatic	ADJ
bam-7218	349	12	muscles	muscle	NOUN
bam-7218	349	13	federica	federica	PROPN
bam-7218	349	14	maiole	maiole	PROPN
bam-7218	349	15	(	(	PUNCT
bam-7218	349	16	a	a	DET
bam-7218	349	17	,	,	PUNCT
bam-7218	349	18	b	b	NOUN
bam-7218	349	19	)	)	PUNCT
bam-7218	349	20	,	,	PUNCT
bam-7218	349	21	fabio	fabio	PROPN
bam-7218	349	22	benfenati	benfenati	PROPN
bam-7218	349	23	(	(	PUNCT
bam-7218	349	24	a	a	DET
bam-7218	349	25	,	,	PUNCT
bam-7218	349	26	c	c	NOUN
bam-7218	349	27	)	)	PUNCT
bam-7218	349	28	,	,	PUNCT
bam-7218	349	29	letizia	letizia	PROPN
bam-7218	349	30	zullo	zullo	PROPN
bam-7218	349	31	(	(	PUNCT
bam-7218	349	32	a	a	NOUN
bam-7218	349	33	)	)	PUNCT
bam-7218	349	34	(	(	PUNCT
bam-7218	349	35	a	a	PRON
bam-7218	349	36	)	)	PUNCT
bam-7218	349	37	center	center	NOUN
bam-7218	349	38	for	for	ADP
bam-7218	349	39	synaptic	synaptic	ADJ
bam-7218	349	40	neuroscience	neuroscience	NOUN
bam-7218	349	41	and	and	CCONJ
bam-7218	349	42	technology	technology	NOUN
bam-7218	349	43	,	,	PUNCT
bam-7218	349	44	istituto	istituto	X
bam-7218	349	45	italiano	italiano	NOUN
bam-7218	349	46	di	di	X
bam-7218	349	47	tecnologia	tecnologia	PROPN
bam-7218	349	48	,	,	PUNCT
bam-7218	349	49	genova	genova	PROPN
bam-7218	349	50	,	,	PUNCT
bam-7218	349	51	italy	italy	PROPN
bam-7218	349	52	;	;	PUNCT
bam-7218	349	53	(	(	PUNCT
bam-7218	349	54	b	b	X
bam-7218	349	55	)	)	PUNCT
bam-7218	349	56	university	university	NOUN
bam-7218	349	57	of	of	ADP
bam-7218	349	58	genova	genova	PROPN
bam-7218	349	59	,	,	PUNCT
bam-7218	349	60	genova	genova	PROPN
bam-7218	349	61	,	,	PUNCT
bam-7218	349	62	italy	italy	PROPN
bam-7218	349	63	;	;	PUNCT
bam-7218	349	64	(	(	PUNCT
bam-7218	349	65	c	c	X
bam-7218	349	66	)	)	PUNCT
bam-7218	349	67	dept	dept	NOUN
bam-7218	349	68	of	of	ADP
bam-7218	349	69	experimental	experimental	ADJ
bam-7218	349	70	medicine	medicine	NOUN
bam-7218	349	71	,	,	PUNCT
bam-7218	349	72	university	university	NOUN
bam-7218	349	73	of	of	ADP
bam-7218	349	74	genova	genova	PROPN
bam-7218	349	75	,	,	PUNCT
bam-7218	349	76	italy	italy	PROPN
bam-7218	349	77	.	.	PUNCT
bam-7218	350	1	e	e	X
bam-7218	350	2	-	-	NOUN
bam-7218	350	3	mail	mail	NOUN
bam-7218	350	4	:	:	PUNCT
bam-7218	350	5	federica.maiole@iit.it	federica.maiole@iit.it	CCONJ
bam-7218	350	6	the	the	DET
bam-7218	350	7	octopus	octopus	NOUN
bam-7218	350	8	arm	arm	NOUN
bam-7218	350	9	is	be	AUX
bam-7218	350	10	composed	compose	VERB
bam-7218	350	11	by	by	ADP
bam-7218	350	12	uninucleated	uninucleated	ADJ
bam-7218	350	13	myofibers	myofiber	NOUN
bam-7218	350	14	packed	pack	VERB
bam-7218	350	15	in	in	ADP
bam-7218	350	16	a	a	DET
bam-7218	350	17	complex	complex	ADJ
bam-7218	350	18	matrix	matrix	NOUN
bam-7218	350	19	of	of	ADP
bam-7218	350	20	connective	connective	ADJ
bam-7218	350	21	tissue	tissue	NOUN
bam-7218	350	22	.	.	PUNCT
bam-7218	351	1	two	two	NUM
bam-7218	351	2	main	main	ADJ
bam-7218	351	3	muscle	muscle	NOUN
bam-7218	351	4	types	type	NOUN
bam-7218	351	5	compose	compose	VERB
bam-7218	351	6	the	the	DET
bam-7218	351	7	arm	arm	NOUN
bam-7218	351	8	bulk	bulk	NOUN
bam-7218	351	9	:	:	PUNCT
bam-7218	351	10	the	the	DET
bam-7218	351	11	longitudinal	longitudinal	ADJ
bam-7218	351	12	(	(	PUNCT
bam-7218	351	13	l	l	NOUN
bam-7218	351	14	)	)	PUNCT
bam-7218	351	15	,	,	PUNCT
bam-7218	351	16	located	locate	VERB
bam-7218	351	17	at	at	ADP
bam-7218	351	18	the	the	DET
bam-7218	351	19	outer	outer	ADJ
bam-7218	351	20	layer	layer	NOUN
bam-7218	351	21	,	,	PUNCT
bam-7218	351	22	and	and	CCONJ
bam-7218	351	23	the	the	DET
bam-7218	351	24	transverse	transverse	NOUN
bam-7218	351	25	(	(	PUNCT
bam-7218	351	26	t	t	PROPN
bam-7218	351	27	)	)	PUNCT
bam-7218	351	28	,	,	PUNCT
bam-7218	351	29	surrounding	surround	VERB
bam-7218	351	30	the	the	DET
bam-7218	351	31	arm	arm	NOUN
bam-7218	351	32	core	core	NOUN
bam-7218	351	33	.	.	PUNCT
bam-7218	352	1	here	here	ADV
bam-7218	352	2	we	we	PRON
bam-7218	352	3	investigated	investigate	VERB
bam-7218	352	4	the	the	DET
bam-7218	352	5	mechanical	mechanical	ADJ
bam-7218	352	6	properties	property	NOUN
bam-7218	352	7	of	of	ADP
bam-7218	352	8	these	these	DET
bam-7218	352	9	muscles	muscle	NOUN
bam-7218	352	10	using	use	VERB
bam-7218	352	11	a	a	DET
bam-7218	352	12	dual	dual	ADJ
bam-7218	352	13	-	-	PUNCT
bam-7218	352	14	mode	mode	NOUN
bam-7218	352	15	lever	lever	NOUN
bam-7218	352	16	system	system	NOUN
bam-7218	352	17	on	on	ADP
bam-7218	352	18	in	in	ADP
bam-7218	352	19	-	-	PUNCT
bam-7218	352	20	vitro	vitro	X
bam-7218	352	21	preparations	preparation	NOUN
bam-7218	352	22	.	.	PUNCT
bam-7218	353	1	we	we	PRON
bam-7218	353	2	show	show	VERB
bam-7218	353	3	that	that	SCONJ
bam-7218	353	4	l	l	NOUN
bam-7218	353	5	and	and	CCONJ
bam-7218	353	6	t	t	PROPN
bam-7218	353	7	muscles	muscle	NOUN
bam-7218	353	8	differ	differ	VERB
bam-7218	353	9	in	in	ADP
bam-7218	353	10	their	their	PRON
bam-7218	353	11	biophysics	biophysic	NOUN
bam-7218	353	12	although	although	SCONJ
bam-7218	353	13	single	single	ADJ
bam-7218	353	14	myofibers	myofiber	NOUN
bam-7218	353	15	share	share	VERB
bam-7218	353	16	the	the	DET
bam-7218	353	17	same	same	ADJ
bam-7218	353	18	physiological	physiological	ADJ
bam-7218	353	19	properties	property	NOUN
bam-7218	353	20	.	.	PUNCT
bam-7218	354	1	to	to	PART
bam-7218	354	2	explore	explore	VERB
bam-7218	354	3	the	the	DET
bam-7218	354	4	bases	basis	NOUN
bam-7218	354	5	of	of	ADP
bam-7218	354	6	these	these	DET
bam-7218	354	7	different	different	ADJ
bam-7218	354	8	mechanical	mechanical	ADJ
bam-7218	354	9	features	feature	NOUN
bam-7218	354	10	,	,	PUNCT
bam-7218	354	11	we	we	PRON
bam-7218	354	12	studied	study	VERB
bam-7218	354	13	the	the	DET
bam-7218	354	14	arm	arm	NOUN
bam-7218	354	15	muscle	muscle	NOUN
bam-7218	354	16	-	-	PUNCT
bam-7218	354	17	connective	connective	ADJ
bam-7218	354	18	interaction	interaction	NOUN
bam-7218	354	19	and	and	CCONJ
bam-7218	354	20	the	the	DET
bam-7218	354	21	possible	possible	ADJ
bam-7218	354	22	role	role	NOUN
bam-7218	354	23	of	of	ADP
bam-7218	354	24	gap	gap	NOUN
bam-7218	354	25	junctions	junction	NOUN
bam-7218	354	26	in	in	ADP
bam-7218	354	27	the	the	DET
bam-7218	354	28	coordination	coordination	NOUN
bam-7218	354	29	of	of	ADP
bam-7218	354	30	muscle	muscle	NOUN
bam-7218	354	31	ensembles	ensemble	NOUN
bam-7218	354	32	.	.	PUNCT
bam-7218	355	1	we	we	PRON
bam-7218	355	2	performed	perform	VERB
bam-7218	355	3	confocal	confocal	ADJ
bam-7218	355	4	microscopy	microscopy	NOUN
bam-7218	355	5	of	of	ADP
bam-7218	355	6	arm	arm	NOUN
bam-7218	355	7	sections	section	NOUN
bam-7218	355	8	and	and	CCONJ
bam-7218	355	9	employed	employ	VERB
bam-7218	355	10	a	a	DET
bam-7218	355	11	waviness	waviness	NOUN
bam-7218	355	12	index	index	NOUN
bam-7218	355	13	(	(	PUNCT
bam-7218	355	14	w.i	w.i	PROPN
bam-7218	355	15	.	.	PUNCT
bam-7218	355	16	)	)	PUNCT
bam-7218	356	1	analysis	analysis	NOUN
bam-7218	356	2	to	to	PART
bam-7218	356	3	measure	measure	VERB
bam-7218	356	4	the	the	DET
bam-7218	356	5	coiling	coiling	NOUN
bam-7218	356	6	of	of	ADP
bam-7218	356	7	elastic	elastic	ADJ
bam-7218	356	8	fibers	fiber	NOUN
bam-7218	356	9	.	.	PUNCT
bam-7218	357	1	w.i	w.i	PROPN
bam-7218	357	2	.	.	PROPN
bam-7218	357	3	was	be	AUX
bam-7218	357	4	found	find	VERB
bam-7218	357	5	to	to	PART
bam-7218	357	6	be	be	AUX
bam-7218	357	7	higher	high	ADJ
bam-7218	357	8	in	in	ADP
bam-7218	357	9	l	l	NOUN
bam-7218	357	10	muscles	muscle	NOUN
bam-7218	357	11	than	than	ADP
bam-7218	357	12	in	in	ADP
bam-7218	357	13	t	t	PROPN
bam-7218	357	14	,	,	PUNCT
bam-7218	357	15	where	where	SCONJ
bam-7218	357	16	elastic	elastic	ADJ
bam-7218	357	17	fibers	fiber	NOUN
bam-7218	357	18	are	be	AUX
bam-7218	357	19	sparsely	sparsely	ADV
bam-7218	357	20	organized	organize	VERB
bam-7218	357	21	.	.	PUNCT
bam-7218	358	1	this	this	DET
bam-7218	358	2	architecture	architecture	NOUN
bam-7218	358	3	contributes	contribute	VERB
bam-7218	358	4	to	to	PART
bam-7218	358	5	accommodate	accommodate	VERB
bam-7218	358	6	strain	strain	NOUN
bam-7218	358	7	during	during	ADP
bam-7218	358	8	movements	movement	NOUN
bam-7218	358	9	and	and	CCONJ
bam-7218	358	10	to	to	PART
bam-7218	358	11	coordinate	coordinate	VERB
bam-7218	358	12	contraction	contraction	NOUN
bam-7218	358	13	of	of	ADP
bam-7218	358	14	antagonistic	antagonistic	ADJ
bam-7218	358	15	muscles	muscle	NOUN
bam-7218	358	16	.	.	PUNCT
bam-7218	359	1	moreover	moreover	ADV
bam-7218	359	2	,	,	PUNCT
bam-7218	359	3	muscle	muscle	NOUN
bam-7218	359	4	fiber	fiber	NOUN
bam-7218	359	5	synchrony	synchrony	NOUN
bam-7218	359	6	is	be	AUX
bam-7218	359	7	achieved	achieve	VERB
bam-7218	359	8	despite	despite	SCONJ
bam-7218	359	9	monosynaptic	monosynaptic	ADJ
bam-7218	359	10	innervation	innervation	NOUN
bam-7218	359	11	and	and	CCONJ
bam-7218	359	12	might	might	AUX
bam-7218	359	13	be	be	AUX
bam-7218	359	14	based	base	VERB
bam-7218	359	15	on	on	ADP
bam-7218	359	16	gap	gap	NOUN
bam-7218	359	17	junction	junction	NOUN
bam-7218	359	18	intercellular	intercellular	ADJ
bam-7218	359	19	connections	connection	NOUN
bam-7218	359	20	.	.	PUNCT
bam-7218	360	1	invertebrates	invertebrate	VERB
bam-7218	360	2	gap	gap	NOUN
bam-7218	360	3	junctions	junction	NOUN
bam-7218	360	4	are	be	AUX
bam-7218	360	5	formed	form	VERB
bam-7218	360	6	by	by	ADP
bam-7218	360	7	innexin	innexin	PROPN
bam-7218	360	8	,	,	PUNCT
bam-7218	360	9	a	a	DET
bam-7218	360	10	family	family	NOUN
bam-7218	360	11	of	of	ADP
bam-7218	360	12	protein	protein	NOUN
bam-7218	360	13	analog	analog	NOUN
bam-7218	360	14	to	to	PART
bam-7218	360	15	vertebrate	vertebrate	VERB
bam-7218	360	16	connexin	connexin	NOUN
bam-7218	360	17	.	.	PUNCT
bam-7218	361	1	as	as	SCONJ
bam-7218	361	2	the	the	DET
bam-7218	361	3	presence	presence	NOUN
bam-7218	361	4	of	of	ADP
bam-7218	361	5	innexins	innexin	NOUN
bam-7218	361	6	might	might	AUX
bam-7218	361	7	be	be	AUX
bam-7218	361	8	an	an	DET
bam-7218	361	9	indicator	indicator	NOUN
bam-7218	361	10	for	for	ADP
bam-7218	361	11	gap	gap	NOUN
bam-7218	361	12	junction	junction	NOUN
bam-7218	361	13	,	,	PUNCT
bam-7218	361	14	we	we	PRON
bam-7218	361	15	sequenced	sequence	VERB
bam-7218	361	16	octopus	octopus	PROPN
bam-7218	361	17	unc-9	unc-9	ADV
bam-7218	361	18	innexin	innexin	NOUN
bam-7218	361	19	and	and	CCONJ
bam-7218	361	20	found	find	VERB
bam-7218	361	21	a	a	DET
bam-7218	361	22	good	good	ADJ
bam-7218	361	23	identity	identity	NOUN
bam-7218	361	24	and	and	CCONJ
bam-7218	361	25	a	a	DET
bam-7218	361	26	comparable	comparable	ADJ
bam-7218	361	27	topology	topology	NOUN
bam-7218	361	28	with	with	ADP
bam-7218	361	29	invertebrate	invertebrate	NOUN
bam-7218	361	30	c.	c.	NOUN
bam-7218	361	31	elegans	elegan	NOUN
bam-7218	361	32	unc-9	unc-9	ADV
bam-7218	361	33	innexin	innexin	NOUN
bam-7218	361	34	.	.	PUNCT
bam-7218	362	1	the	the	DET
bam-7218	362	2	presence	presence	NOUN
bam-7218	362	3	of	of	ADP
bam-7218	362	4	gap	gap	NOUN
bam-7218	362	5	junction	junction	NOUN
bam-7218	362	6	might	might	AUX
bam-7218	362	7	suggest	suggest	VERB
bam-7218	362	8	that	that	SCONJ
bam-7218	362	9	octopus	octopus	NOUN
bam-7218	362	10	arm	arm	NOUN
bam-7218	362	11	muscles	muscle	NOUN
bam-7218	362	12	evolved	evolve	VERB
bam-7218	362	13	together	together	ADV
bam-7218	362	14	with	with	ADP
bam-7218	362	15	a	a	DET
bam-7218	362	16	fine	fine	ADV
bam-7218	362	17	-	-	PUNCT
bam-7218	362	18	tuned	tune	VERB
bam-7218	362	19	coordination	coordination	NOUN
bam-7218	362	20	control	control	NOUN
bam-7218	362	21	mechanism	mechanism	NOUN
bam-7218	362	22	.	.	PUNCT
bam-7218	363	1	october	october	PROPN
bam-7218	363	2	13	13	NUM
bam-7218	363	3	th	th	NOUN
bam-7218	363	4	session	session	NOUN
bam-7218	363	5	3	3	NUM
bam-7218	363	6	satellite	satellite	NOUN
bam-7218	363	7	cells	cell	NOUN
bam-7218	363	8	and	and	CCONJ
bam-7218	363	9	muscle	muscle	NOUN
bam-7218	363	10	regeneration	regeneration	NOUN
bam-7218	363	11	in	in	ADP
bam-7218	363	12	healty	healty	PROPN
bam-7218	363	13	muscle	muscle	NOUN
bam-7218	363	14	and	and	CCONJ
bam-7218	363	15	in	in	ADP
bam-7218	363	16	diseases	disease	NOUN
bam-7218	363	17	3.1	3.1	NUM
bam-7218	363	18	hdac4	hdac4	NOUN
bam-7218	363	19	regulates	regulate	VERB
bam-7218	363	20	satellite	satellite	NOUN
bam-7218	363	21	cell	cell	NOUN
bam-7218	363	22	proliferation	proliferation	NOUN
bam-7218	363	23	and	and	CCONJ
bam-7218	363	24	differentiation	differentiation	NOUN
bam-7218	363	25	by	by	ADP
bam-7218	363	26	targeting	target	VERB
bam-7218	363	27	p21	p21	NOUN
bam-7218	363	28	and	and	CCONJ
bam-7218	363	29	sharp1	sharp1	NOUN
bam-7218	363	30	genes	gene	NOUN
bam-7218	363	31	marco	marco	PROPN
bam-7218	363	32	bertin	bertin	PROPN
bam-7218	363	33	(	(	PUNCT
bam-7218	363	34	a	a	NOUN
bam-7218	363	35	)	)	PUNCT
bam-7218	363	36	,	,	PUNCT
bam-7218	363	37	nicoletta	nicoletta	PROPN
bam-7218	363	38	marroncelli	marroncelli	PROPN
bam-7218	363	39	(	(	PUNCT
bam-7218	363	40	a	a	PROPN
bam-7218	363	41	)	)	PUNCT
bam-7218	363	42	,	,	PUNCT
bam-7218	363	43	marzia	marzia	PROPN
bam-7218	363	44	bianchi	bianchi	NOUN
bam-7218	363	45	(	(	PUNCT
bam-7218	363	46	a	a	X
bam-7218	363	47	)	)	PUNCT
bam-7218	363	48	,	,	PUNCT
bam-7218	363	49	silvia	silvia	PROPN
bam-7218	363	50	consalvi	consalvi	PROPN
bam-7218	363	51	(	(	PUNCT
bam-7218	363	52	b	b	NOUN
bam-7218	363	53	)	)	PUNCT
bam-7218	363	54	,	,	PUNCT
bam-7218	363	55	valentina	valentina	PROPN
bam-7218	363	56	saccone	saccone	PROPN
bam-7218	363	57	(	(	PUNCT
bam-7218	363	58	b	b	NOUN
bam-7218	363	59	)	)	PUNCT
bam-7218	363	60	,	,	PUNCT
bam-7218	363	61	marco	marco	PROPN
bam-7218	363	62	de	de	PROPN
bam-7218	363	63	bardi	bardi	PROPN
bam-7218	363	64	(	(	PUNCT
bam-7218	363	65	b	b	NOUN
bam-7218	363	66	)	)	PUNCT
bam-7218	363	67	,	,	PUNCT
bam-7218	363	68	pier	pier	PROPN
bam-7218	363	69	lorenzo	lorenzo	PROPN
bam-7218	363	70	puri	puri	PROPN
bam-7218	363	71	(	(	PUNCT
bam-7218	363	72	b	b	NOUN
bam-7218	363	73	)	)	PUNCT
bam-7218	363	74	,	,	PUNCT
bam-7218	363	75	daniela	daniela	PROPN
bam-7218	363	76	palacios	palacio	NOUN
bam-7218	363	77	(	(	PUNCT
bam-7218	363	78	b	b	NOUN
bam-7218	363	79	)	)	PUNCT
bam-7218	363	80	,	,	PUNCT
bam-7218	363	81	sergio	sergio	PROPN
bam-7218	363	82	adamo	adamo	PROPN
bam-7218	363	83	(	(	PUNCT
bam-7218	363	84	a	a	PROPN
bam-7218	363	85	)	)	PUNCT
bam-7218	363	86	,	,	PUNCT
bam-7218	363	87	viviana	viviana	PROPN
bam-7218	363	88	moresi	moresi	PROPN
bam-7218	363	89	(	(	PUNCT
bam-7218	363	90	a	a	DET
bam-7218	363	91	,	,	PUNCT
bam-7218	363	92	c	c	NOUN
bam-7218	363	93	)	)	PUNCT
bam-7218	363	94	(	(	PUNCT
bam-7218	363	95	a	a	X
bam-7218	363	96	)	)	PUNCT
bam-7218	363	97	dahfmo	dahfmo	NOUN
bam-7218	363	98	unit	unit	NOUN
bam-7218	363	99	of	of	ADP
bam-7218	363	100	histology	histology	NOUN
bam-7218	363	101	and	and	CCONJ
bam-7218	363	102	medical	medical	ADJ
bam-7218	363	103	embryology	embryology	PROPN
bam-7218	363	104	,	,	PUNCT
bam-7218	363	105	interuniversity	interuniversity	NOUN
bam-7218	363	106	institute	institute	PROPN
bam-7218	363	107	of	of	ADP
bam-7218	363	108	myology	myology	NOUN
bam-7218	363	109	,	,	PUNCT
bam-7218	363	110	sapienza	sapienza	PROPN
bam-7218	363	111	university	university	PROPN
bam-7218	363	112	of	of	ADP
bam-7218	363	113	rome	rome	PROPN
bam-7218	363	114	,	,	PUNCT
bam-7218	363	115	italy	italy	PROPN
bam-7218	363	116	.	.	PUNCT
bam-7218	364	1	(	(	PUNCT
bam-7218	364	2	b	b	X
bam-7218	364	3	)	)	PUNCT
bam-7218	364	4	irccs	irccs	NOUN
bam-7218	364	5	fondazione	fondazione	NOUN
bam-7218	364	6	santa	santa	PROPN
bam-7218	364	7	lucia	lucia	PROPN
bam-7218	364	8	,	,	PUNCT
bam-7218	364	9	rome	rome	PROPN
bam-7218	364	10	,	,	PUNCT
bam-7218	364	11	italy	italy	PROPN
bam-7218	364	12	.	.	PUNCT
bam-7218	365	1	(	(	PUNCT
bam-7218	365	2	c	c	X
bam-7218	365	3	)	)	PUNCT
bam-7218	365	4	laboratory	laboratory	NOUN
bam-7218	365	5	of	of	ADP
bam-7218	365	6	cardiovascular	cardiovascular	ADJ
bam-7218	365	7	endocrinology	endocrinology	NOUN
bam-7218	365	8	,	,	PUNCT
bam-7218	365	9	irccs	ircc	VERB
bam-7218	365	10	san	san	PROPN
bam-7218	365	11	raffaele	raffaele	PROPN
bam-7218	365	12	pisana	pisana	PROPN
bam-7218	365	13	,	,	PUNCT
bam-7218	365	14	rome	rome	PROPN
bam-7218	365	15	,	,	PUNCT
bam-7218	365	16	italy	italy	PROPN
bam-7218	365	17	.	.	PUNCT
bam-7218	366	1	e	e	X
bam-7218	366	2	-	-	NOUN
bam-7218	366	3	mail	mail	NOUN
bam-7218	366	4	:	:	PUNCT
bam-7218	366	5	marco.bertin22@gmail.com	marco.bertin22@gmail.com	NOUN
bam-7218	367	1	mailto:federica.maiole@iit.it	mailto:federica.maiole@iit.it	NUM
bam-7218	367	2	mailto:marco.bertin22@gmail.com	mailto:marco.bertin22@gmail.com	PROPN
bam-7218	367	3	14	14	NUM
bam-7218	367	4	th	th	NUM
bam-7218	367	5	iiim	iiim	NOUN
bam-7218	367	6	meeting	meeting	NOUN
bam-7218	367	7	,	,	PUNCT
bam-7218	367	8	assisi	assisi	PROPN
bam-7218	367	9	,	,	PUNCT
bam-7218	367	10	italy	italy	PROPN
bam-7218	367	11	october	october	PROPN
bam-7218	367	12	12	12	NUM
bam-7218	367	13	-	-	SYM
bam-7218	367	14	15	15	NUM
bam-7218	367	15	2017	2017	NUM
bam-7218	367	16	eur	eur	PROPN
bam-7218	367	17	j	j	PROPN
bam-7218	367	18	transl	transl	PROPN
bam-7218	367	19	myol	myol	ADV
bam-7218	367	20	27	27	NUM
bam-7218	367	21	(	(	PUNCT
bam-7218	367	22	4	4	NUM
bam-7218	367	23	):	):	SYM
bam-7218	367	24	185	185	NUM
bam-7218	367	25	-	-	SYM
bam-7218	367	26	224	224	NUM
bam-7218	367	27	195	195	NUM
bam-7218	367	28	skeletal	skeletal	ADJ
bam-7218	367	29	muscle	muscle	NOUN
bam-7218	367	30	exhibits	exhibit	VERB
bam-7218	367	31	a	a	DET
bam-7218	367	32	high	high	ADJ
bam-7218	367	33	capacity	capacity	NOUN
bam-7218	367	34	to	to	PART
bam-7218	367	35	regenerate	regenerate	VERB
bam-7218	367	36	,	,	PUNCT
bam-7218	367	37	mainly	mainly	ADV
bam-7218	367	38	due	due	ADP
bam-7218	367	39	to	to	ADP
bam-7218	367	40	the	the	DET
bam-7218	367	41	ability	ability	NOUN
bam-7218	367	42	of	of	ADP
bam-7218	367	43	satellite	satellite	NOUN
bam-7218	367	44	cells	cell	NOUN
bam-7218	367	45	to	to	PART
bam-7218	367	46	replicate	replicate	VERB
bam-7218	367	47	and	and	CCONJ
bam-7218	367	48	differentiate	differentiate	VERB
bam-7218	367	49	in	in	ADP
bam-7218	367	50	response	response	NOUN
bam-7218	367	51	to	to	ADP
bam-7218	367	52	stimuli	stimulus	NOUN
bam-7218	367	53	.	.	PUNCT
bam-7218	368	1	epigenetic	epigenetic	ADJ
bam-7218	368	2	control	control	NOUN
bam-7218	368	3	is	be	AUX
bam-7218	368	4	effective	effective	ADJ
bam-7218	368	5	at	at	ADP
bam-7218	368	6	multiple	multiple	ADJ
bam-7218	368	7	steps	step	NOUN
bam-7218	368	8	of	of	ADP
bam-7218	368	9	this	this	DET
bam-7218	368	10	process	process	NOUN
bam-7218	368	11	,	,	PUNCT
bam-7218	368	12	regulating	regulate	VERB
bam-7218	368	13	the	the	DET
bam-7218	368	14	transition	transition	NOUN
bam-7218	368	15	from	from	ADP
bam-7218	368	16	quiescence	quiescence	NOUN
bam-7218	368	17	to	to	ADP
bam-7218	368	18	activation	activation	NOUN
bam-7218	368	19	and	and	CCONJ
bam-7218	368	20	differentiation	differentiation	NOUN
bam-7218	368	21	of	of	ADP
bam-7218	368	22	muscle	muscle	NOUN
bam-7218	368	23	stem	stem	NOUN
bam-7218	368	24	cells1	cells1	ADJ
bam-7218	368	25	.	.	PUNCT
bam-7218	369	1	the	the	DET
bam-7218	369	2	chromatin	chromatin	NOUN
bam-7218	369	3	-	-	PUNCT
bam-7218	369	4	remodelling	remodelle	VERB
bam-7218	369	5	factor	factor	NOUN
bam-7218	369	6	,	,	PUNCT
bam-7218	369	7	hdac4	hdac4	PROPN
bam-7218	369	8	,	,	PUNCT
bam-7218	369	9	has	have	AUX
bam-7218	369	10	been	be	AUX
bam-7218	369	11	shown	show	VERB
bam-7218	369	12	to	to	PART
bam-7218	369	13	regulate	regulate	VERB
bam-7218	369	14	satellite	satellite	NOUN
bam-7218	369	15	cell	cell	NOUN
bam-7218	369	16	proliferation	proliferation	NOUN
bam-7218	369	17	and	and	CCONJ
bam-7218	369	18	commitment2	commitment2	NOUN
bam-7218	369	19	;	;	PUNCT
bam-7218	369	20	however	however	ADV
bam-7218	369	21	,	,	PUNCT
bam-7218	369	22	the	the	DET
bam-7218	369	23	underlying	underlie	VERB
bam-7218	369	24	molecular	molecular	ADJ
bam-7218	369	25	mechanisms	mechanism	NOUN
bam-7218	369	26	are	be	AUX
bam-7218	369	27	still	still	ADV
bam-7218	369	28	uncovered	uncover	VERB
bam-7218	369	29	.	.	PUNCT
bam-7218	370	1	to	to	PART
bam-7218	370	2	study	study	VERB
bam-7218	370	3	hdac4	hdac4	NOUN
bam-7218	370	4	in	in	ADP
bam-7218	370	5	satellite	satellite	NOUN
bam-7218	370	6	cells	cell	NOUN
bam-7218	370	7	,	,	PUNCT
bam-7218	370	8	we	we	PRON
bam-7218	370	9	generated	generate	VERB
bam-7218	370	10	a	a	DET
bam-7218	370	11	conditional	conditional	ADJ
bam-7218	370	12	inducible	inducible	ADJ
bam-7218	370	13	ko	ko	PROPN
bam-7218	370	14	mouse	mouse	NOUN
bam-7218	370	15	line	line	NOUN
bam-7218	370	16	,	,	PUNCT
bam-7218	370	17	in	in	ADP
bam-7218	370	18	which	which	PRON
bam-7218	370	19	hdac4	hdac4	NOUN
bam-7218	370	20	is	be	AUX
bam-7218	370	21	deleted	delete	VERB
bam-7218	370	22	in	in	ADP
bam-7218	370	23	pax7	pax7	ADJ
bam-7218	370	24	positive	positive	ADJ
bam-7218	370	25	cells	cell	NOUN
bam-7218	370	26	,	,	PUNCT
bam-7218	370	27	upon	upon	SCONJ
bam-7218	370	28	tamoxifen	tamoxifen	PROPN
bam-7218	370	29	administration	administration	NOUN
bam-7218	370	30	.	.	PUNCT
bam-7218	371	1	despite	despite	SCONJ
bam-7218	371	2	having	have	VERB
bam-7218	371	3	similar	similar	ADJ
bam-7218	371	4	amounts	amount	NOUN
bam-7218	371	5	of	of	ADP
bam-7218	371	6	satellite	satellite	NOUN
bam-7218	371	7	cells	cell	NOUN
bam-7218	371	8	,	,	PUNCT
bam-7218	371	9	hdac4	hdac4	NOUN
bam-7218	371	10	ko	ko	PROPN
bam-7218	371	11	mice	mouse	NOUN
bam-7218	371	12	show	show	PROPN
bam-7218	371	13	compromised	compromise	VERB
bam-7218	371	14	satellite	satellite	NOUN
bam-7218	371	15	cell	cell	NOUN
bam-7218	371	16	proliferation	proliferation	NOUN
bam-7218	371	17	and	and	CCONJ
bam-7218	371	18	differentiation	differentiation	NOUN
bam-7218	371	19	in	in	ADP
bam-7218	371	20	vitro	vitro	VERB
bam-7218	371	21	.	.	PUNCT
bam-7218	372	1	to	to	PART
bam-7218	372	2	identify	identify	VERB
bam-7218	372	3	the	the	DET
bam-7218	372	4	molecular	molecular	ADJ
bam-7218	372	5	targets	target	NOUN
bam-7218	372	6	regulated	regulate	VERB
bam-7218	372	7	by	by	ADP
bam-7218	372	8	hdac4	hdac4	NOUN
bam-7218	372	9	in	in	ADP
bam-7218	372	10	satellite	satellite	NOUN
bam-7218	372	11	cells	cell	NOUN
bam-7218	372	12	,	,	PUNCT
bam-7218	372	13	we	we	PRON
bam-7218	372	14	performed	perform	VERB
bam-7218	372	15	a	a	DET
bam-7218	372	16	chip	chip	NOUN
bam-7218	372	17	-	-	PUNCT
bam-7218	372	18	seq	seq	NOUN
bam-7218	372	19	analysis	analysis	NOUN
bam-7218	372	20	by	by	ADP
bam-7218	372	21	immuno	immuno	NOUN
bam-7218	372	22	-	-	PUNCT
bam-7218	372	23	precipitating	precipitate	VERB
bam-7218	372	24	the	the	DET
bam-7218	372	25	endogenous	endogenous	ADJ
bam-7218	372	26	hdac4	hdac4	NOUN
bam-7218	372	27	in	in	ADP
bam-7218	372	28	proliferative	proliferative	ADJ
bam-7218	372	29	muscle	muscle	NOUN
bam-7218	372	30	cells	cell	NOUN
bam-7218	372	31	and	and	CCONJ
bam-7218	372	32	we	we	PRON
bam-7218	372	33	performed	perform	VERB
bam-7218	372	34	a	a	DET
bam-7218	372	35	rna	rna	NOUN
bam-7218	372	36	-	-	PUNCT
bam-7218	372	37	seq	seq	NOUN
bam-7218	372	38	analysis	analysis	NOUN
bam-7218	372	39	by	by	ADP
bam-7218	372	40	comparing	compare	VERB
bam-7218	372	41	control	control	NOUN
bam-7218	372	42	and	and	CCONJ
bam-7218	372	43	hdac4	hdac4	NOUN
bam-7218	372	44	ko	ko	PROPN
bam-7218	372	45	satellite	satellite	NOUN
bam-7218	372	46	cells	cell	NOUN
bam-7218	372	47	.	.	PUNCT
bam-7218	373	1	by	by	ADP
bam-7218	373	2	intersecting	intersect	VERB
bam-7218	373	3	the	the	DET
bam-7218	373	4	results	result	NOUN
bam-7218	373	5	of	of	ADP
bam-7218	373	6	the	the	DET
bam-7218	373	7	chip	chip	NOUN
bam-7218	373	8	-	-	PUNCT
bam-7218	373	9	seq	seq	NOUN
bam-7218	373	10	with	with	ADP
bam-7218	373	11	the	the	DET
bam-7218	373	12	list	list	NOUN
bam-7218	373	13	of	of	ADP
bam-7218	373	14	the	the	DET
bam-7218	373	15	genes	gene	NOUN
bam-7218	373	16	significantly	significantly	ADV
bam-7218	373	17	up	up	ADV
bam-7218	373	18	-	-	PUNCT
bam-7218	373	19	regulated	regulate	VERB
bam-7218	373	20	in	in	ADP
bam-7218	373	21	hdac4	hdac4	NOUN
bam-7218	373	22	ko	ko	PROPN
bam-7218	373	23	satellite	satellite	NOUN
bam-7218	373	24	cells	cell	NOUN
bam-7218	373	25	from	from	ADP
bam-7218	373	26	the	the	DET
bam-7218	373	27	rna	rna	PROPN
bam-7218	373	28	-	-	PUNCT
bam-7218	373	29	seq	seq	NOUN
bam-7218	373	30	,	,	PUNCT
bam-7218	373	31	we	we	PRON
bam-7218	373	32	identified	identify	VERB
bam-7218	373	33	two	two	NUM
bam-7218	373	34	candidates	candidate	NOUN
bam-7218	373	35	,	,	PUNCT
bam-7218	373	36	p21	p21	NOUN
bam-7218	373	37	and	and	CCONJ
bam-7218	373	38	sharp1	sharp1	NOUN
bam-7218	373	39	,	,	PUNCT
bam-7218	373	40	as	as	ADP
bam-7218	373	41	direct	direct	ADJ
bam-7218	373	42	targets	target	NOUN
bam-7218	373	43	of	of	ADP
bam-7218	373	44	hdac4	hdac4	NOUN
bam-7218	373	45	in	in	ADP
bam-7218	373	46	proliferating	proliferate	VERB
bam-7218	373	47	muscle	muscle	NOUN
bam-7218	373	48	cells	cell	NOUN
bam-7218	373	49	.	.	PUNCT
bam-7218	374	1	by	by	ADP
bam-7218	374	2	interfering	interfere	VERB
bam-7218	374	3	with	with	ADP
bam-7218	374	4	their	their	PRON
bam-7218	374	5	expression	expression	NOUN
bam-7218	374	6	,	,	PUNCT
bam-7218	374	7	we	we	PRON
bam-7218	374	8	demonstrated	demonstrate	VERB
bam-7218	374	9	that	that	SCONJ
bam-7218	374	10	hdac4	hdac4	NOUN
bam-7218	374	11	-	-	PUNCT
bam-7218	374	12	mediated	mediate	VERB
bam-7218	374	13	repression	repression	NOUN
bam-7218	374	14	of	of	ADP
bam-7218	374	15	the	the	DET
bam-7218	374	16	cell	cell	NOUN
bam-7218	374	17	cycle	cycle	NOUN
bam-7218	374	18	inhibitor	inhibitor	NOUN
bam-7218	374	19	p21	p21	NOUN
bam-7218	374	20	,	,	PUNCT
bam-7218	374	21	promotes	promote	VERB
bam-7218	374	22	satellite	satellite	NOUN
bam-7218	374	23	cell	cell	NOUN
bam-7218	374	24	amplification	amplification	NOUN
bam-7218	374	25	;	;	PUNCT
bam-7218	374	26	while	while	SCONJ
bam-7218	374	27	hdac4	hdac4	NOUN
bam-7218	374	28	-	-	PUNCT
bam-7218	374	29	mediated	mediate	VERB
bam-7218	374	30	repression	repression	NOUN
bam-7218	374	31	of	of	ADP
bam-7218	374	32	sharp1	sharp1	NOUN
bam-7218	374	33	,	,	PUNCT
bam-7218	374	34	allows	allow	VERB
bam-7218	374	35	satellite	satellite	NOUN
bam-7218	374	36	cell	cell	NOUN
bam-7218	374	37	differentiation	differentiation	NOUN
bam-7218	374	38	and	and	CCONJ
bam-7218	374	39	fusion	fusion	NOUN
bam-7218	374	40	.	.	PUNCT
bam-7218	375	1	these	these	DET
bam-7218	375	2	data	datum	NOUN
bam-7218	375	3	identify	identify	VERB
bam-7218	375	4	hdac4	hdac4	NOUN
bam-7218	375	5	-	-	PUNCT
bam-7218	375	6	mediated	mediate	VERB
bam-7218	375	7	regulation	regulation	NOUN
bam-7218	375	8	of	of	ADP
bam-7218	375	9	genes	gene	NOUN
bam-7218	375	10	that	that	PRON
bam-7218	375	11	control	control	VERB
bam-7218	375	12	two	two	NUM
bam-7218	375	13	sequential	sequential	ADJ
bam-7218	375	14	stages	stage	NOUN
bam-7218	375	15	of	of	ADP
bam-7218	375	16	satellite	satellite	NOUN
bam-7218	375	17	cell	cell	NOUN
bam-7218	375	18	activity	activity	NOUN
bam-7218	375	19	during	during	ADP
bam-7218	375	20	myogenesis	myogenesis	NOUN
bam-7218	375	21	,	,	PUNCT
bam-7218	375	22	such	such	ADJ
bam-7218	375	23	as	as	ADP
bam-7218	375	24	proliferation	proliferation	NOUN
bam-7218	375	25	and	and	CCONJ
bam-7218	375	26	differentiation	differentiation	NOUN
bam-7218	375	27	into	into	ADP
bam-7218	375	28	new	new	ADJ
bam-7218	375	29	fibers	fiber	NOUN
bam-7218	375	30	.	.	PUNCT
bam-7218	376	1	references	reference	NOUN
bam-7218	376	2	:	:	PUNCT
bam-7218	376	3	1	1	X
bam-7218	376	4	.	.	X
bam-7218	376	5	world	world	PROPN
bam-7218	376	6	j	j	PROPN
bam-7218	376	7	stem	stem	NOUN
bam-7218	376	8	cells	cell	NOUN
bam-7218	376	9	.	.	PUNCT
bam-7218	377	1	2015	2015	NUM
bam-7218	377	2	jul	jul	NOUN
bam-7218	377	3	26;7(6):945	26;7(6):945	NUM
bam-7218	377	4	-	-	SYM
bam-7218	377	5	55	55	NUM
bam-7218	377	6	;	;	PUNCT
bam-7218	377	7	2	2	NUM
bam-7218	377	8	.	.	X
bam-7218	377	9	embo	embo	PROPN
bam-7218	377	10	rep	rep	PROPN
bam-7218	377	11	.	.	PROPN
bam-7218	377	12	2014	2014	NUM
bam-7218	377	13	nov;15(11):1175	nov;15(11):1175	PROPN
bam-7218	377	14	-	-	PUNCT
bam-7218	377	15	83	83	NUM
bam-7218	377	16	.	.	PUNCT
bam-7218	377	17	3.2	3.2	NUM
bam-7218	377	18	a	a	DET
bam-7218	377	19	first	first	ADJ
bam-7218	377	20	look	look	NOUN
bam-7218	377	21	at	at	ADP
bam-7218	377	22	acid	acid	NOUN
bam-7218	377	23	sphingomyelinase	sphingomyelinase	NOUN
bam-7218	377	24	in	in	ADP
bam-7218	377	25	the	the	DET
bam-7218	377	26	pathophysiology	pathophysiology	NOUN
bam-7218	377	27	of	of	ADP
bam-7218	377	28	duchenne	duchenne	PROPN
bam-7218	377	29	muscular	muscular	ADJ
bam-7218	377	30	dystrophy	dystrophy	NOUN
bam-7218	377	31	ilaria	ilaria	PROPN
bam-7218	377	32	di	di	PROPN
bam-7218	377	33	renzo	renzo	PROPN
bam-7218	377	34	(	(	PUNCT
bam-7218	377	35	a	a	NOUN
bam-7218	377	36	)	)	PUNCT
bam-7218	377	37	,	,	PUNCT
bam-7218	377	38	clara	clara	PROPN
bam-7218	377	39	de	de	PROPN
bam-7218	377	40	palma	palma	PROPN
bam-7218	377	41	(	(	PUNCT
bam-7218	377	42	b	b	NOUN
bam-7218	377	43	)	)	PUNCT
bam-7218	377	44	,	,	PUNCT
bam-7218	377	45	matteo	matteo	PROPN
bam-7218	377	46	giovarelli	giovarelli	PROPN
bam-7218	377	47	(	(	PUNCT
bam-7218	377	48	a	a	NOUN
bam-7218	377	49	)	)	PUNCT
bam-7218	377	50	,	,	PUNCT
bam-7218	377	51	emilio	emilio	PROPN
bam-7218	377	52	clementi	clementi	PROPN
bam-7218	377	53	(	(	PUNCT
bam-7218	377	54	a	a	DET
bam-7218	377	55	,	,	PUNCT
bam-7218	377	56	b	b	NOUN
bam-7218	377	57	,	,	PUNCT
bam-7218	377	58	c	c	NOUN
bam-7218	377	59	)	)	PUNCT
bam-7218	377	60	,	,	PUNCT
bam-7218	377	61	cristiana	cristiana	PROPN
bam-7218	377	62	perrotta	perrotta	PROPN
bam-7218	377	63	(	(	PUNCT
bam-7218	377	64	a	a	NOUN
bam-7218	377	65	)	)	PUNCT
bam-7218	377	66	(	(	PUNCT
bam-7218	377	67	a	a	X
bam-7218	377	68	)	)	PUNCT
bam-7218	377	69	dept	dept	NOUN
bam-7218	377	70	of	of	ADP
bam-7218	377	71	biomedical	biomedical	ADJ
bam-7218	377	72	and	and	CCONJ
bam-7218	377	73	clinical	clinical	ADJ
bam-7218	377	74	sciences	science	NOUN
bam-7218	377	75	“	"	PUNCT
bam-7218	377	76	luigi	luigi	PROPN
bam-7218	377	77	sacco	sacco	PROPN
bam-7218	377	78	”	"	PUNCT
bam-7218	377	79	,	,	PUNCT
bam-7218	377	80	università	università	PROPN
bam-7218	377	81	degli	degli	PROPN
bam-7218	377	82	studi	studi	PROPN
bam-7218	377	83	di	di	X
bam-7218	377	84	milano	milano	PROPN
bam-7218	377	85	,	,	PUNCT
bam-7218	377	86	milano	milano	PROPN
bam-7218	377	87	,	,	PUNCT
bam-7218	377	88	italy	italy	PROPN
bam-7218	377	89	;	;	PUNCT
bam-7218	377	90	(	(	PUNCT
bam-7218	377	91	b	b	X
bam-7218	377	92	)	)	PUNCT
bam-7218	377	93	unit	unit	NOUN
bam-7218	377	94	of	of	ADP
bam-7218	377	95	clinical	clinical	ADJ
bam-7218	377	96	pharmacology	pharmacology	NOUN
bam-7218	377	97	,	,	PUNCT
bam-7218	377	98	university	university	NOUN
bam-7218	377	99	hospital	hospital	NOUN
bam-7218	377	100	“	"	PUNCT
bam-7218	377	101	luigi	luigi	PROPN
bam-7218	377	102	sacco”asst	sacco”asst	PROPN
bam-7218	377	103	fatebenefratelli	fatebenefratelli	PROPN
bam-7218	377	104	sacco	sacco	PROPN
bam-7218	377	105	;	;	PUNCT
bam-7218	377	106	national	national	PROPN
bam-7218	377	107	research	research	PROPN
bam-7218	377	108	council	council	PROPN
bam-7218	377	109	-	-	PUNCT
bam-7218	377	110	institute	institute	PROPN
bam-7218	377	111	of	of	ADP
bam-7218	377	112	neuroscience	neuroscience	NOUN
bam-7218	377	113	;	;	PUNCT
bam-7218	377	114	dept	dept	NOUN
bam-7218	377	115	of	of	ADP
bam-7218	377	116	biomedical	biomedical	ADJ
bam-7218	377	117	and	and	CCONJ
bam-7218	377	118	clinical	clinical	ADJ
bam-7218	377	119	sciences	science	NOUN
bam-7218	377	120	,	,	PUNCT
bam-7218	377	121	università	università	PROPN
bam-7218	377	122	degli	degli	PROPN
bam-7218	377	123	studi	studi	PROPN
bam-7218	377	124	di	di	X
bam-7218	377	125	milano	milano	PROPN
bam-7218	377	126	,	,	PUNCT
bam-7218	377	127	milano	milano	PROPN
bam-7218	377	128	,	,	PUNCT
bam-7218	377	129	italy	italy	PROPN
bam-7218	377	130	;	;	PUNCT
bam-7218	377	131	(	(	PUNCT
bam-7218	377	132	c	c	X
bam-7218	377	133	)	)	PUNCT
bam-7218	377	134	irccs	irccs	NOUN
bam-7218	377	135	eugenio	eugenio	PROPN
bam-7218	377	136	medea	medea	PROPN
bam-7218	377	137	,	,	PUNCT
bam-7218	377	138	bosisio	bosisio	ADJ
bam-7218	377	139	parini	parini	PROPN
bam-7218	377	140	,	,	PUNCT
bam-7218	377	141	italy	italy	PROPN
bam-7218	377	142	.	.	PUNCT
bam-7218	378	1	e	e	X
bam-7218	378	2	-	-	NOUN
bam-7218	378	3	mail	mail	NOUN
bam-7218	378	4	:	:	PUNCT
bam-7218	378	5	ilaria.direnzo1989@gmail.com	ilaria.direnzo1989@gmail.com	NUM
bam-7218	378	6	skeletal	skeletal	ADJ
bam-7218	378	7	muscle	muscle	NOUN
bam-7218	378	8	inflammation	inflammation	NOUN
bam-7218	378	9	is	be	AUX
bam-7218	378	10	an	an	DET
bam-7218	378	11	important	important	ADJ
bam-7218	378	12	feature	feature	NOUN
bam-7218	378	13	of	of	ADP
bam-7218	378	14	different	different	ADJ
bam-7218	378	15	myopathies	myopathy	NOUN
bam-7218	378	16	and	and	CCONJ
bam-7218	378	17	supportive	supportive	ADJ
bam-7218	378	18	evidence	evidence	NOUN
bam-7218	378	19	for	for	ADP
bam-7218	378	20	the	the	DET
bam-7218	378	21	relevance	relevance	NOUN
bam-7218	378	22	of	of	ADP
bam-7218	378	23	inflammation	inflammation	NOUN
bam-7218	378	24	in	in	ADP
bam-7218	378	25	promoting	promote	VERB
bam-7218	378	26	dystrophinrelated	dystrophinrelate	VERB
bam-7218	378	27	diseases	disease	NOUN
bam-7218	378	28	come	come	VERB
bam-7218	378	29	from	from	ADP
bam-7218	378	30	the	the	DET
bam-7218	378	31	beneficial	beneficial	ADJ
bam-7218	378	32	effect	effect	NOUN
bam-7218	378	33	of	of	ADP
bam-7218	378	34	corticosteroids	corticosteroid	NOUN
bam-7218	378	35	in	in	ADP
bam-7218	378	36	the	the	DET
bam-7218	378	37	treatment	treatment	NOUN
bam-7218	378	38	of	of	ADP
bam-7218	378	39	duchenne	duchenne	ADJ
bam-7218	378	40	muscular	muscular	ADJ
bam-7218	378	41	dystrophy	dystrophy	NOUN
bam-7218	378	42	(	(	PUNCT
bam-7218	378	43	dmd	dmd	NOUN
bam-7218	378	44	)	)	PUNCT
bam-7218	378	45	.	.	PUNCT
bam-7218	379	1	although	although	SCONJ
bam-7218	379	2	many	many	ADJ
bam-7218	379	3	studies	study	NOUN
bam-7218	379	4	have	have	AUX
bam-7218	379	5	been	be	AUX
bam-7218	379	6	focused	focus	VERB
bam-7218	379	7	on	on	ADP
bam-7218	379	8	the	the	DET
bam-7218	379	9	role	role	NOUN
bam-7218	379	10	of	of	ADP
bam-7218	379	11	bioactive	bioactive	ADJ
bam-7218	379	12	sphingolipids	sphingolipid	NOUN
bam-7218	379	13	in	in	ADP
bam-7218	379	14	inflammatory	inflammatory	ADJ
bam-7218	379	15	-	-	PUNCT
bam-7218	379	16	associated	associate	VERB
bam-7218	379	17	disorders	disorder	NOUN
bam-7218	379	18	,	,	PUNCT
bam-7218	379	19	the	the	DET
bam-7218	379	20	involvement	involvement	NOUN
bam-7218	379	21	of	of	ADP
bam-7218	379	22	hydrolase	hydrolase	NOUN
bam-7218	379	23	acid	acid	NOUN
bam-7218	379	24	sphingomyelinase	sphingomyelinase	NOUN
bam-7218	379	25	(	(	PUNCT
bam-7218	379	26	a	a	DET
bam-7218	379	27	-	-	PUNCT
bam-7218	379	28	smase	smase	NOUN
bam-7218	379	29	)	)	PUNCT
bam-7218	379	30	in	in	ADP
bam-7218	379	31	dmdrelated	dmdrelate	VERB
bam-7218	379	32	inflammation	inflammation	NOUN
bam-7218	379	33	is	be	AUX
bam-7218	379	34	currently	currently	ADV
bam-7218	379	35	unknown	unknown	ADJ
bam-7218	379	36	.	.	PUNCT
bam-7218	380	1	our	our	PRON
bam-7218	380	2	results	result	NOUN
bam-7218	380	3	showed	show	VERB
bam-7218	380	4	that	that	SCONJ
bam-7218	380	5	a	a	DET
bam-7218	380	6	-	-	PUNCT
bam-7218	380	7	smase	smase	NOUN
bam-7218	380	8	is	be	AUX
bam-7218	380	9	overexpressed	overexpresse	VERB
bam-7218	380	10	in	in	ADP
bam-7218	380	11	skeletal	skeletal	ADJ
bam-7218	380	12	muscles	muscle	NOUN
bam-7218	380	13	of	of	ADP
bam-7218	380	14	mdx	mdx	PROPN
bam-7218	380	15	mouse	mouse	PROPN
bam-7218	380	16	model	model	NOUN
bam-7218	380	17	of	of	ADP
bam-7218	380	18	dmd	dmd	NOUN
bam-7218	380	19	,	,	PUNCT
bam-7218	380	20	both	both	PRON
bam-7218	380	21	at	at	ADP
bam-7218	380	22	4	4	NUM
bam-7218	380	23	and	and	CCONJ
bam-7218	380	24	12	12	NUM
bam-7218	380	25	weeks	week	NOUN
bam-7218	380	26	of	of	ADP
bam-7218	380	27	age	age	NOUN
bam-7218	380	28	.	.	PUNCT
bam-7218	381	1	the	the	DET
bam-7218	381	2	initial	initial	ADJ
bam-7218	381	3	inflammatory	inflammatory	ADJ
bam-7218	381	4	response	response	NOUN
bam-7218	381	5	during	during	ADP
bam-7218	381	6	chronic	chronic	ADJ
bam-7218	381	7	muscle	muscle	NOUN
bam-7218	381	8	injury	injury	NOUN
bam-7218	381	9	is	be	AUX
bam-7218	381	10	similar	similar	ADJ
bam-7218	381	11	to	to	ADP
bam-7218	381	12	the	the	DET
bam-7218	381	13	response	response	NOUN
bam-7218	381	14	to	to	ADP
bam-7218	381	15	acute	acute	ADJ
bam-7218	381	16	damage	damage	NOUN
bam-7218	381	17	.	.	PUNCT
bam-7218	382	1	to	to	PART
bam-7218	382	2	study	study	VERB
bam-7218	382	3	a	a	DET
bam-7218	382	4	possible	possible	ADJ
bam-7218	382	5	role	role	NOUN
bam-7218	382	6	of	of	ADP
bam-7218	382	7	a	a	DET
bam-7218	382	8	-	-	PUNCT
bam-7218	382	9	smase	smase	NOUN
bam-7218	382	10	in	in	ADP
bam-7218	382	11	muscle	muscle	NOUN
bam-7218	382	12	regeneration	regeneration	NOUN
bam-7218	382	13	we	we	PRON
bam-7218	382	14	injected	inject	VERB
bam-7218	382	15	cardiotoxin	cardiotoxin	NOUN
bam-7218	382	16	in	in	ADP
bam-7218	382	17	tibialis	tibialis	NOUN
bam-7218	382	18	anteriors	anterior	NOUN
bam-7218	382	19	of	of	ADP
bam-7218	382	20	wild	wild	ADJ
bam-7218	382	21	-	-	PUNCT
bam-7218	382	22	type	type	NOUN
bam-7218	382	23	(	(	PUNCT
bam-7218	382	24	wt	wt	NOUN
bam-7218	382	25	)	)	PUNCT
bam-7218	382	26	and	and	CCONJ
bam-7218	382	27	a	a	DET
bam-7218	382	28	-	-	PUNCT
bam-7218	382	29	smase	smase	NOUN
bam-7218	382	30	knock	knock	NOUN
bam-7218	382	31	-	-	PUNCT
bam-7218	382	32	out	out	NOUN
bam-7218	382	33	(	(	PUNCT
bam-7218	382	34	ko	ko	PROPN
bam-7218	382	35	)	)	PUNCT
bam-7218	382	36	mice	mouse	NOUN
bam-7218	382	37	thus	thus	ADV
bam-7218	382	38	inducing	induce	VERB
bam-7218	382	39	acute	acute	ADJ
bam-7218	382	40	muscle	muscle	NOUN
bam-7218	382	41	damage	damage	NOUN
bam-7218	382	42	.	.	PUNCT
bam-7218	383	1	of	of	ADP
bam-7218	383	2	interest	interest	NOUN
bam-7218	383	3	,	,	PUNCT
bam-7218	383	4	the	the	DET
bam-7218	383	5	expression	expression	NOUN
bam-7218	383	6	of	of	ADP
bam-7218	383	7	myogenin	myogenin	PROPN
bam-7218	383	8	,	,	PUNCT
bam-7218	383	9	a	a	DET
bam-7218	383	10	marker	marker	NOUN
bam-7218	383	11	of	of	ADP
bam-7218	383	12	muscle	muscle	NOUN
bam-7218	383	13	differentiation	differentiation	NOUN
bam-7218	383	14	,	,	PUNCT
bam-7218	383	15	significantly	significantly	ADV
bam-7218	383	16	increased	increase	VERB
bam-7218	383	17	in	in	ADP
bam-7218	383	18	asmase	asmase	NOUN
bam-7218	383	19	-	-	PUNCT
bam-7218	383	20	ko	ko	NOUN
bam-7218	383	21	mice	mouse	NOUN
bam-7218	383	22	when	when	SCONJ
bam-7218	383	23	compared	compare	VERB
bam-7218	383	24	to	to	ADP
bam-7218	383	25	wt	wt	PROPN
bam-7218	383	26	after	after	ADP
bam-7218	383	27	cardiotoxin	cardiotoxin	NOUN
bam-7218	383	28	administration	administration	NOUN
bam-7218	383	29	.	.	PUNCT
bam-7218	384	1	in	in	ADP
bam-7218	384	2	addition	addition	NOUN
bam-7218	384	3	,	,	PUNCT
bam-7218	384	4	a	a	DET
bam-7218	384	5	-	-	PUNCT
bam-7218	384	6	smase	smase	NOUN
bam-7218	384	7	-	-	PUNCT
bam-7218	384	8	ko	ko	NOUN
bam-7218	384	9	mice	mice	NOUN
bam-7218	384	10	muscles	muscle	NOUN
bam-7218	384	11	showed	show	VERB
bam-7218	384	12	enhanced	enhanced	ADJ
bam-7218	384	13	levels	level	NOUN
bam-7218	384	14	of	of	ADP
bam-7218	384	15	the	the	DET
bam-7218	384	16	anti	anti	ADJ
bam-7218	384	17	-	-	ADJ
bam-7218	384	18	inflammatory	inflammatory	ADJ
bam-7218	384	19	cytokines	cytokine	NOUN
bam-7218	384	20	and	and	CCONJ
bam-7218	384	21	arginase	arginase	NOUN
bam-7218	384	22	,	,	PUNCT
bam-7218	384	23	an	an	DET
bam-7218	384	24	enzyme	enzyme	NOUN
bam-7218	384	25	which	which	PRON
bam-7218	384	26	is	be	AUX
bam-7218	384	27	positively	positively	ADV
bam-7218	384	28	related	relate	VERB
bam-7218	384	29	to	to	ADP
bam-7218	384	30	muscle	muscle	NOUN
bam-7218	384	31	regeneration	regeneration	NOUN
bam-7218	384	32	.	.	PUNCT
bam-7218	385	1	these	these	DET
bam-7218	385	2	data	datum	NOUN
bam-7218	385	3	,	,	PUNCT
bam-7218	385	4	although	although	SCONJ
bam-7218	385	5	preliminary	preliminary	ADJ
bam-7218	385	6	,	,	PUNCT
bam-7218	385	7	provide	provide	VERB
bam-7218	385	8	the	the	DET
bam-7218	385	9	first	first	ADJ
bam-7218	385	10	evidence	evidence	NOUN
bam-7218	385	11	that	that	SCONJ
bam-7218	385	12	in	in	ADP
bam-7218	385	13	the	the	DET
bam-7218	385	14	absence	absence	NOUN
bam-7218	385	15	of	of	ADP
bam-7218	385	16	a	a	DET
bam-7218	385	17	-	-	PUNCT
bam-7218	385	18	smase	smase	NOUN
bam-7218	385	19	muscle	muscle	NOUN
bam-7218	385	20	regeneration	regeneration	NOUN
bam-7218	385	21	is	be	AUX
bam-7218	385	22	accelerated	accelerate	VERB
bam-7218	385	23	and	and	CCONJ
bam-7218	385	24	suggest	suggest	VERB
bam-7218	385	25	a	a	DET
bam-7218	385	26	role	role	NOUN
bam-7218	385	27	of	of	ADP
bam-7218	385	28	a	a	DET
bam-7218	385	29	-	-	PUNCT
bam-7218	385	30	smase	smase	NOUN
bam-7218	385	31	in	in	ADP
bam-7218	385	32	the	the	DET
bam-7218	385	33	pathophysiology	pathophysiology	NOUN
bam-7218	385	34	of	of	ADP
bam-7218	385	35	dmd	dmd	NOUN
bam-7218	385	36	.	.	PROPN
bam-7218	385	37	3.3	3.3	NUM
bam-7218	385	38	muscle	muscle	NOUN
bam-7218	385	39	perivascular	perivascular	ADJ
bam-7218	385	40	stem	stem	NOUN
bam-7218	385	41	cells	cell	NOUN
bam-7218	385	42	for	for	ADP
bam-7218	385	43	advanced	advanced	ADJ
bam-7218	385	44	skeletal	skeletal	ADJ
bam-7218	385	45	muscle	muscle	NOUN
bam-7218	385	46	tissue	tissue	NOUN
bam-7218	385	47	regenerative	regenerative	ADJ
bam-7218	385	48	approaches	approach	NOUN
bam-7218	385	49	ersilia	ersilia	PROPN
bam-7218	385	50	fornetti	fornetti	PROPN
bam-7218	385	51	,	,	PUNCT
bam-7218	385	52	stefano	stefano	PROPN
bam-7218	385	53	testa	testa	PROPN
bam-7218	385	54	,	,	PUNCT
bam-7218	385	55	claudia	claudia	NOUN
bam-7218	385	56	fuoco	fuoco	NOUN
bam-7218	385	57	,	,	PUNCT
bam-7218	385	58	gianni	gianni	PROPN
bam-7218	385	59	cesareni	cesareni	PROPN
bam-7218	385	60	,	,	PUNCT
bam-7218	385	61	stefano	stefano	PROPN
bam-7218	385	62	cannata	cannata	PROPN
bam-7218	385	63	,	,	PUNCT
bam-7218	385	64	cesare	cesare	PROPN
bam-7218	385	65	gargioli	gargioli	PROPN
bam-7218	385	66	dept	dept	PROPN
bam-7218	385	67	of	of	ADP
bam-7218	385	68	biology	biology	NOUN
bam-7218	385	69	,	,	PUNCT
bam-7218	385	70	rome	rome	PROPN
bam-7218	385	71	university	university	NOUN
bam-7218	385	72	tor	tor	PROPN
bam-7218	385	73	vergata	vergata	PROPN
bam-7218	385	74	,	,	PUNCT
bam-7218	385	75	rome	rome	PROPN
bam-7218	385	76	,	,	PUNCT
bam-7218	385	77	italy	italy	PROPN
bam-7218	385	78	.	.	PUNCT
bam-7218	386	1	e	e	X
bam-7218	386	2	-	-	NOUN
bam-7218	386	3	mail	mail	NOUN
bam-7218	386	4	:	:	PUNCT
bam-7218	386	5	ersiforn@hotmail.it	ersiforn@hotmail.it	PROPN
bam-7218	386	6	skeletal	skeletal	ADJ
bam-7218	386	7	muscle	muscle	NOUN
bam-7218	386	8	tissue	tissue	NOUN
bam-7218	386	9	engineering	engineering	NOUN
bam-7218	386	10	represents	represent	VERB
bam-7218	386	11	a	a	DET
bam-7218	386	12	revolutionary	revolutionary	ADJ
bam-7218	386	13	approach	approach	NOUN
bam-7218	386	14	for	for	ADP
bam-7218	386	15	the	the	DET
bam-7218	386	16	treatment	treatment	NOUN
bam-7218	386	17	of	of	ADP
bam-7218	386	18	musculoskeletal	musculoskeletal	ADJ
bam-7218	386	19	tissue	tissue	NOUN
bam-7218	386	20	pathologies1	pathologies1	NOUN
bam-7218	386	21	.	.	PUNCT
bam-7218	387	1	however	however	ADV
bam-7218	387	2	,	,	PUNCT
bam-7218	387	3	there	there	PRON
bam-7218	387	4	are	be	VERB
bam-7218	387	5	some	some	DET
bam-7218	387	6	limitations	limitation	NOUN
bam-7218	387	7	related	relate	VERB
bam-7218	387	8	to	to	ADP
bam-7218	387	9	the	the	DET
bam-7218	387	10	complex	complex	ADJ
bam-7218	387	11	muscle	muscle	NOUN
bam-7218	387	12	architectural	architectural	ADJ
bam-7218	387	13	organization	organization	NOUN
bam-7218	387	14	and	and	CCONJ
bam-7218	387	15	to	to	ADP
bam-7218	387	16	the	the	DET
bam-7218	387	17	difficulty	difficulty	NOUN
bam-7218	387	18	to	to	PART
bam-7218	387	19	find	find	VERB
bam-7218	387	20	a	a	DET
bam-7218	387	21	reliable	reliable	ADJ
bam-7218	387	22	and	and	CCONJ
bam-7218	387	23	appropriate	appropriate	ADJ
bam-7218	387	24	source	source	NOUN
bam-7218	387	25	of	of	ADP
bam-7218	387	26	myogenic	myogenic	ADJ
bam-7218	387	27	progenitors	progenitor	NOUN
bam-7218	387	28	able	able	ADJ
bam-7218	387	29	to	to	PART
bam-7218	387	30	sustain	sustain	VERB
bam-7218	387	31	swift	swift	ADJ
bam-7218	387	32	vascularization	vascularization	NOUN
bam-7218	387	33	.	.	PUNCT
bam-7218	388	1	recent	recent	ADJ
bam-7218	388	2	studies	study	NOUN
bam-7218	388	3	have	have	AUX
bam-7218	388	4	led	lead	VERB
bam-7218	388	5	to	to	ADP
bam-7218	388	6	the	the	DET
bam-7218	388	7	identification	identification	NOUN
bam-7218	388	8	of	of	ADP
bam-7218	388	9	a	a	DET
bam-7218	388	10	new	new	ADJ
bam-7218	388	11	muscle	muscle	NOUN
bam-7218	388	12	progenitor	progenitor	NOUN
bam-7218	388	13	cell	cell	NOUN
bam-7218	388	14	population	population	NOUN
bam-7218	388	15	namely	namely	ADV
bam-7218	388	16	pericytes2	pericytes2	VERB
bam-7218	388	17	.	.	PUNCT
bam-7218	389	1	these	these	PRON
bam-7218	389	2	are	be	AUX
bam-7218	389	3	perivascular	perivascular	ADJ
bam-7218	389	4	muscle	muscle	NOUN
bam-7218	389	5	progenitors	progenitor	NOUN
bam-7218	389	6	able	able	ADJ
bam-7218	389	7	to	to	PART
bam-7218	389	8	undergo	undergo	VERB
bam-7218	389	9	a	a	DET
bam-7218	389	10	robust	robust	ADJ
bam-7218	389	11	myogenic	myogenic	ADJ
bam-7218	389	12	differentiation	differentiation	NOUN
bam-7218	389	13	beside	beside	ADP
bam-7218	389	14	a	a	DET
bam-7218	389	15	preserved	preserve	VERB
bam-7218	389	16	angiogenic	angiogenic	ADJ
bam-7218	389	17	ability3,4	ability3,4	PROPN
bam-7218	389	18	.	.	PUNCT
bam-7218	390	1	human	human	ADJ
bam-7218	390	2	derived	derive	VERB
bam-7218	390	3	pericytes	pericyte	NOUN
bam-7218	390	4	(	(	PUNCT
bam-7218	390	5	hperi	hperi	NOUN
bam-7218	390	6	)	)	PUNCT
bam-7218	390	7	were	be	AUX
bam-7218	390	8	isolated	isolate	VERB
bam-7218	390	9	from	from	ADP
bam-7218	390	10	human	human	ADJ
bam-7218	390	11	muscle	muscle	NOUN
bam-7218	390	12	biopsies	biopsy	NOUN
bam-7218	390	13	by	by	ADP
bam-7218	390	14	enzymatic	enzymatic	ADJ
bam-7218	390	15	digestion	digestion	NOUN
bam-7218	390	16	and	and	CCONJ
bam-7218	390	17	selected	select	VERB
bam-7218	390	18	for	for	ADP
bam-7218	390	19	low	low	ADJ
bam-7218	390	20	confluence	confluence	NOUN
bam-7218	390	21	plastic	plastic	NOUN
bam-7218	390	22	adhesion	adhesion	NOUN
bam-7218	390	23	and	and	CCONJ
bam-7218	390	24	alkaline	alkaline	NOUN
bam-7218	390	25	phosphatase	phosphatase	NOUN
bam-7218	390	26	(	(	PUNCT
bam-7218	390	27	ap	ap	PROPN
bam-7218	390	28	)	)	PUNCT
bam-7218	390	29	expression5	expression5	NOUN
bam-7218	390	30	,	,	PUNCT
bam-7218	390	31	showing	show	VERB
bam-7218	390	32	colony	colony	NOUN
bam-7218	390	33	forming	form	VERB
bam-7218	390	34	capability	capability	NOUN
bam-7218	390	35	and	and	CCONJ
bam-7218	390	36	a	a	DET
bam-7218	390	37	remarkable	remarkable	ADJ
bam-7218	390	38	spontaneous	spontaneous	ADJ
bam-7218	390	39	myogenic	myogenic	ADJ
bam-7218	390	40	activity	activity	NOUN
bam-7218	390	41	.	.	PUNCT
bam-7218	391	1	hperi	hperi	PROPN
bam-7218	391	2	were	be	AUX
bam-7218	391	3	characterized	characterize	VERB
bam-7218	391	4	in	in	ADP
bam-7218	391	5	vitro	vitro	X
bam-7218	391	6	for	for	ADP
bam-7218	391	7	mesodermic	mesodermic	ADJ
bam-7218	391	8	differentiation	differentiation	NOUN
bam-7218	391	9	and	and	CCONJ
bam-7218	391	10	in	in	ADP
bam-7218	391	11	vivo	vivo	NOUN
bam-7218	391	12	by	by	ADP
bam-7218	391	13	intramuscular	intramuscular	ADJ
bam-7218	391	14	injection	injection	NOUN
bam-7218	391	15	,	,	PUNCT
bam-7218	391	16	revealing	reveal	VERB
bam-7218	391	17	their	their	PRON
bam-7218	391	18	astonishing	astonishing	ADJ
bam-7218	391	19	myogenic	myogenic	ADJ
bam-7218	391	20	capability	capability	NOUN
bam-7218	391	21	.	.	PUNCT
bam-7218	392	1	moreover	moreover	ADV
bam-7218	392	2	,	,	PUNCT
bam-7218	392	3	for	for	ADP
bam-7218	392	4	skeletal	skeletal	ADJ
bam-7218	392	5	muscle	muscle	NOUN
bam-7218	392	6	tissue	tissue	NOUN
bam-7218	392	7	engineering	engineering	NOUN
bam-7218	392	8	purpose	purpose	NOUN
bam-7218	392	9	,	,	PUNCT
bam-7218	392	10	it	it	PRON
bam-7218	392	11	was	be	AUX
bam-7218	392	12	evaluated	evaluate	VERB
bam-7218	392	13	the	the	DET
bam-7218	392	14	combination	combination	NOUN
bam-7218	392	15	of	of	ADP
bam-7218	392	16	hperi	hperi	NOUN
bam-7218	392	17	and	and	CCONJ
bam-7218	392	18	peg	peg	NOUN
bam-7218	392	19	-	-	PUNCT
bam-7218	392	20	fibrinogen	fibrinogen	NOUN
bam-7218	392	21	(	(	PUNCT
bam-7218	392	22	pf	pf	NOUN
bam-7218	392	23	)	)	PUNCT
bam-7218	392	24	based	base	VERB
bam-7218	392	25	biomimetic	biomimetic	ADJ
bam-7218	392	26	scaffold6	scaffold6	NOUN
bam-7218	392	27	for	for	ADP
bam-7218	392	28	building	build	VERB
bam-7218	392	29	a	a	DET
bam-7218	392	30	human	human	ADJ
bam-7218	392	31	derived	derive	VERB
bam-7218	392	32	artificial	artificial	ADJ
bam-7218	392	33	muscle	muscle	NOUN
bam-7218	392	34	in	in	ADP
bam-7218	392	35	vivo	vivo	NOUN
bam-7218	392	36	upon	upon	SCONJ
bam-7218	392	37	subcutaneous	subcutaneous	ADJ
bam-7218	392	38	mailto:ilaria.direnzo1989@gmail.com	mailto:ilaria.direnzo1989@gmail.com	NOUN
bam-7218	392	39	mailto:ersiforn@hotmail.it	mailto:ersiforn@hotmail.it	NOUN
bam-7218	392	40	14	14	NUM
bam-7218	392	41	th	th	NUM
bam-7218	392	42	iiim	iiim	NOUN
bam-7218	392	43	meeting	meeting	NOUN
bam-7218	392	44	,	,	PUNCT
bam-7218	392	45	assisi	assisi	PROPN
bam-7218	392	46	,	,	PUNCT
bam-7218	392	47	italy	italy	PROPN
bam-7218	392	48	october	october	PROPN
bam-7218	392	49	12	12	NUM
bam-7218	392	50	-	-	SYM
bam-7218	392	51	15	15	NUM
bam-7218	392	52	2017	2017	NUM
bam-7218	392	53	eur	eur	PROPN
bam-7218	392	54	j	j	PROPN
bam-7218	392	55	transl	transl	PROPN
bam-7218	392	56	myol	myol	ADV
bam-7218	392	57	27	27	NUM
bam-7218	392	58	(	(	PUNCT
bam-7218	392	59	4	4	NUM
bam-7218	392	60	):	):	SYM
bam-7218	392	61	185	185	NUM
bam-7218	392	62	-	-	SYM
bam-7218	392	63	224	224	NUM
bam-7218	392	64	196	196	NUM
bam-7218	392	65	implantation	implantation	NOUN
bam-7218	392	66	.	.	PUNCT
bam-7218	393	1	the	the	DET
bam-7218	393	2	results	result	NOUN
bam-7218	393	3	obtained	obtain	VERB
bam-7218	393	4	showed	show	VERB
bam-7218	393	5	that	that	SCONJ
bam-7218	393	6	pf	pf	PROPN
bam-7218	393	7	based	base	VERB
bam-7218	393	8	matrix	matrix	NOUN
bam-7218	393	9	encapsulating	encapsulate	VERB
bam-7218	393	10	hpery	hpery	NOUN
bam-7218	393	11	promoted	promote	VERB
bam-7218	393	12	the	the	DET
bam-7218	393	13	generation	generation	NOUN
bam-7218	393	14	of	of	ADP
bam-7218	393	15	an	an	DET
bam-7218	393	16	engineered	engineer	VERB
bam-7218	393	17	human	human	ADJ
bam-7218	393	18	derived	derive	VERB
bam-7218	393	19	muscle	muscle	NOUN
bam-7218	393	20	,	,	PUNCT
bam-7218	393	21	moreover	moreover	ADV
bam-7218	393	22	presenting	present	VERB
bam-7218	393	23	an	an	DET
bam-7218	393	24	important	important	ADJ
bam-7218	393	25	vascularization	vascularization	NOUN
bam-7218	393	26	upon	upon	SCONJ
bam-7218	393	27	hperi	hperi	NOUN
bam-7218	393	28	angiogenic	angiogenic	ADJ
bam-7218	393	29	action	action	NOUN
bam-7218	393	30	.	.	PUNCT
bam-7218	394	1	hence	hence	ADV
bam-7218	394	2	the	the	DET
bam-7218	394	3	perivascular	perivascular	ADJ
bam-7218	394	4	compartment	compartment	NOUN
bam-7218	394	5	with	with	ADP
bam-7218	394	6	hperi	hperi	NOUN
bam-7218	394	7	can	can	AUX
bam-7218	394	8	be	be	AUX
bam-7218	394	9	considered	consider	VERB
bam-7218	394	10	a	a	DET
bam-7218	394	11	remarkable	remarkable	ADJ
bam-7218	394	12	reliable	reliable	ADJ
bam-7218	394	13	source	source	NOUN
bam-7218	394	14	for	for	ADP
bam-7218	394	15	myogenic	myogenic	ADJ
bam-7218	394	16	stem	stem	NOUN
bam-7218	394	17	/	/	SYM
bam-7218	394	18	progenitor	progenitor	NOUN
bam-7218	394	19	cells	cell	NOUN
bam-7218	394	20	.	.	PUNCT
bam-7218	395	1	references	reference	NOUN
bam-7218	395	2	:	:	PUNCT
bam-7218	395	3	1	1	X
bam-7218	395	4	.	.	X
bam-7218	395	5	bian	bian	PROPN
bam-7218	395	6	w	w	PROPN
bam-7218	395	7	,	,	PUNCT
bam-7218	395	8	bursac	bursac	PROPN
bam-7218	395	9	n.	n.	PROPN
bam-7218	395	10	ieee	ieee	PROPN
bam-7218	395	11	eng	eng	PROPN
bam-7218	395	12	med	med	PROPN
bam-7218	395	13	biol	biol	PROPN
bam-7218	395	14	mag	mag	CCONJ
bam-7218	396	1	2008;27:109	2008;27:109	NUM
bam-7218	396	2	-	-	SYM
bam-7218	396	3	13	13	NUM
bam-7218	396	4	.	.	NOUN
bam-7218	397	1	2	2	NUM
bam-7218	397	2	.	.	X
bam-7218	397	3	armulik	armulik	PROPN
bam-7218	398	1	a	a	DET
bam-7218	398	2	et	et	PROPN
bam-7218	398	3	al	al	PROPN
bam-7218	398	4	.	.	PROPN
bam-7218	398	5	dev	dev	PROPN
bam-7218	398	6	cell	cell	NOUN
bam-7218	398	7	2011;21:193215	2011;21:193215	NUM
bam-7218	398	8	.	.	PUNCT
bam-7218	398	9	3.birbrair	3.birbrair	NUM
bam-7218	398	10	a	a	PRON
bam-7218	398	11	et	et	PROPN
bam-7218	398	12	al	al	PROPN
bam-7218	398	13	.	.	PROPN
bam-7218	399	1	clin	clin	PROPN
bam-7218	399	2	sci	sci	PROPN
bam-7218	399	3	(	(	PUNCT
bam-7218	399	4	lond	lond	ADJ
bam-7218	399	5	)	)	PUNCT
bam-7218	399	6	2015;128:81	2015;128:81	NUM
bam-7218	399	7	-	-	SYM
bam-7218	399	8	93	93	NUM
bam-7218	399	9	.	.	PUNCT
bam-7218	400	1	4	4	NUM
bam-7218	400	2	.	.	X
bam-7218	400	3	hellström	hellström	PROPN
bam-7218	400	4	m	m	PROPN
bam-7218	400	5	,	,	PUNCT
bam-7218	400	6	et	et	PROPN
bam-7218	400	7	al	al	PROPN
bam-7218	400	8	.	.	PUNCT
bam-7218	401	1	j	j	PROPN
bam-7218	401	2	cell	cell	NOUN
bam-7218	401	3	biol	biol	PROPN
bam-7218	401	4	2001;153:543	2001;153:543	NUM
bam-7218	401	5	-	-	SYM
bam-7218	401	6	54	54	NUM
bam-7218	401	7	.	.	PUNCT
bam-7218	402	1	5.crisan	5.crisan	NUM
bam-7218	402	2	m	m	PROPN
bam-7218	402	3	,	,	PUNCT
bam-7218	402	4	et	et	PROPN
bam-7218	402	5	al	al	PROPN
bam-7218	402	6	.	.	PROPN
bam-7218	402	7	cell	cell	NOUN
bam-7218	402	8	stem	stem	NOUN
bam-7218	402	9	cell	cell	NOUN
bam-7218	402	10	2008	2008	NUM
bam-7218	402	11	,	,	PUNCT
bam-7218	402	12	3:301	3:301	NUM
bam-7218	402	13	-	-	SYM
bam-7218	402	14	313	313	NUM
bam-7218	402	15	.	.	NOUN
bam-7218	403	1	6	6	NUM
bam-7218	403	2	.	.	PUNCT
bam-7218	403	3	almany	almany	NOUN
bam-7218	403	4	l	l	PROPN
bam-7218	403	5	,	,	PUNCT
bam-7218	403	6	seliktar	seliktar	NOUN
bam-7218	403	7	d	d	NOUN
bam-7218	403	8	biomaterials	biomaterial	NOUN
bam-7218	403	9	2005	2005	NUM
bam-7218	403	10	,	,	PUNCT
bam-7218	403	11	26:2467	26:2467	NOUN
bam-7218	403	12	-	-	NOUN
bam-7218	403	13	2477	2477	NUM
bam-7218	403	14	.	.	PUNCT
bam-7218	404	1	3.4	3.4	NUM
bam-7218	404	2	mitochondrial	mitochondrial	ADJ
bam-7218	404	3	bioenergetic	bioenergetic	ADJ
bam-7218	404	4	profile	profile	NOUN
bam-7218	404	5	in	in	ADP
bam-7218	404	6	correlation	correlation	NOUN
bam-7218	404	7	with	with	ADP
bam-7218	404	8	ros	ros	PROPN
bam-7218	404	9	production	production	NOUN
bam-7218	404	10	in	in	ADP
bam-7218	404	11	young	young	ADJ
bam-7218	404	12	and	and	CCONJ
bam-7218	404	13	elderly	elderly	ADJ
bam-7218	404	14	human	human	ADJ
bam-7218	404	15	satellite	satellite	NOUN
bam-7218	404	16	cells	cell	NOUN
bam-7218	404	17	mariangela	mariangela	ADP
bam-7218	404	18	marrone	marrone	PROPN
bam-7218	404	19	(	(	PUNCT
bam-7218	404	20	a	a	PRON
bam-7218	404	21	,	,	PUNCT
bam-7218	404	22	b	b	NOUN
bam-7218	404	23	,	,	PUNCT
bam-7218	404	24	c	c	NOUN
bam-7218	404	25	)	)	PUNCT
bam-7218	404	26	,	,	PUNCT
bam-7218	404	27	rita	rita	PROPN
bam-7218	404	28	maria	maria	PROPN
bam-7218	404	29	laura	laura	PROPN
bam-7218	404	30	la	la	PROPN
bam-7218	404	31	rovere	rovere	PROPN
bam-7218	404	32	(	(	PUNCT
bam-7218	404	33	d	d	NOUN
bam-7218	404	34	)	)	PUNCT
bam-7218	404	35	,	,	PUNCT
bam-7218	404	36	simone	simone	PROPN
bam-7218	404	37	guarnieri	guarnieri	PROPN
bam-7218	404	38	(	(	PUNCT
bam-7218	404	39	a	a	X
bam-7218	404	40	)	)	PUNCT
bam-7218	404	41	,	,	PUNCT
bam-7218	404	42	stefania	stefania	NOUN
bam-7218	404	43	fulle	fulle	ADV
bam-7218	404	44	(	(	PUNCT
bam-7218	404	45	a	a	DET
bam-7218	404	46	,	,	PUNCT
bam-7218	404	47	b	b	NOUN
bam-7218	404	48	,	,	PUNCT
bam-7218	404	49	c	c	NOUN
bam-7218	404	50	)	)	PUNCT
bam-7218	404	51	,	,	PUNCT
bam-7218	404	52	geert	geert	PROPN
bam-7218	404	53	bultynck	bultynck	NOUN
bam-7218	404	54	(	(	PUNCT
bam-7218	404	55	d	d	NOUN
bam-7218	404	56	)	)	PUNCT
bam-7218	404	57	,	,	PUNCT
bam-7218	404	58	rosa	rosa	PROPN
bam-7218	404	59	mancinelli	mancinelli	PROPN
bam-7218	404	60	(	(	PUNCT
bam-7218	404	61	a	a	DET
bam-7218	404	62	,	,	PUNCT
bam-7218	404	63	b	b	NOUN
bam-7218	404	64	,	,	PUNCT
bam-7218	404	65	c	c	NOUN
bam-7218	404	66	)	)	PUNCT
bam-7218	404	67	(	(	PUNCT
bam-7218	404	68	a	a	X
bam-7218	404	69	)	)	PUNCT
bam-7218	404	70	dept	dept	NOUN
bam-7218	404	71	of	of	ADP
bam-7218	404	72	neuroscience	neuroscience	NOUN
bam-7218	404	73	,	,	PUNCT
bam-7218	404	74	imaging	imaging	NOUN
bam-7218	404	75	and	and	CCONJ
bam-7218	404	76	clinical	clinical	ADJ
bam-7218	404	77	sciences	science	NOUN
bam-7218	404	78	,	,	PUNCT
bam-7218	404	79	“	"	PUNCT
bam-7218	404	80	g.	g.	PROPN
bam-7218	404	81	d’annunzio	d’annunzio	PROPN
bam-7218	404	82	”	"	PUNCT
bam-7218	404	83	university	university	NOUN
bam-7218	404	84	,	,	PUNCT
bam-7218	404	85	chietipescara	chietipescara	NOUN
bam-7218	404	86	,	,	PUNCT
bam-7218	404	87	italy	italy	PROPN
bam-7218	404	88	;	;	PUNCT
bam-7218	404	89	(	(	PUNCT
bam-7218	404	90	b	b	X
bam-7218	404	91	)	)	PUNCT
bam-7218	404	92	interuniversity	interuniversity	NOUN
bam-7218	404	93	institute	institute	PROPN
bam-7218	404	94	of	of	ADP
bam-7218	404	95	myology	myology	NOUN
bam-7218	404	96	,	,	PUNCT
bam-7218	404	97	chieti	chieti	PROPN
bam-7218	404	98	,	,	PUNCT
bam-7218	404	99	italy	italy	PROPN
bam-7218	404	100	;	;	PUNCT
bam-7218	404	101	(	(	PUNCT
bam-7218	404	102	c	c	X
bam-7218	404	103	)	)	PUNCT
bam-7218	404	104	laboratory	laboratory	NOUN
bam-7218	404	105	of	of	ADP
bam-7218	404	106	functional	functional	ADJ
bam-7218	404	107	evaluation	evaluation	NOUN
bam-7218	404	108	,	,	PUNCT
bam-7218	404	109	“	"	PUNCT
bam-7218	404	110	g.	g.	PROPN
bam-7218	404	111	d’annunzio	d’annunzio	PROPN
bam-7218	404	112	”	"	PUNCT
bam-7218	404	113	university	university	NOUN
bam-7218	404	114	,	,	PUNCT
bam-7218	404	115	chieti	chieti	PROPN
bam-7218	404	116	-	-	PUNCT
bam-7218	404	117	pescara	pescara	PROPN
bam-7218	404	118	,	,	PUNCT
bam-7218	404	119	italy	italy	PROPN
bam-7218	404	120	;	;	PUNCT
bam-7218	404	121	(	(	PUNCT
bam-7218	404	122	d	d	X
bam-7218	404	123	)	)	PUNCT
bam-7218	404	124	dept	dept	NOUN
bam-7218	404	125	of	of	ADP
bam-7218	404	126	cellular	cellular	ADJ
bam-7218	404	127	and	and	CCONJ
bam-7218	404	128	molecular	molecular	ADJ
bam-7218	404	129	medicine	medicine	NOUN
bam-7218	404	130	,	,	PUNCT
bam-7218	404	131	laboratory	laboratory	NOUN
bam-7218	404	132	of	of	ADP
bam-7218	404	133	molecular	molecular	ADJ
bam-7218	404	134	and	and	CCONJ
bam-7218	404	135	cellular	cellular	ADJ
bam-7218	404	136	signaling	signaling	NOUN
bam-7218	404	137	,	,	PUNCT
bam-7218	404	138	leuven	leuven	PROPN
bam-7218	404	139	,	,	PUNCT
bam-7218	404	140	belgium	belgium	NOUN
bam-7218	404	141	.	.	PUNCT
bam-7218	405	1	e	e	X
bam-7218	405	2	-	-	NOUN
bam-7218	405	3	mail	mail	NOUN
bam-7218	405	4	:	:	PUNCT
bam-7218	405	5	mariangela.marrone19@libero.it	mariangela.marrone19@libero.it	NOUN
bam-7218	405	6	sarcopenia	sarcopenia	PROPN
bam-7218	405	7	is	be	AUX
bam-7218	405	8	defined	define	VERB
bam-7218	405	9	as	as	ADP
bam-7218	405	10	the	the	DET
bam-7218	405	11	age	age	NOUN
bam-7218	405	12	-	-	PUNCT
bam-7218	405	13	related	relate	VERB
bam-7218	405	14	loss	loss	NOUN
bam-7218	405	15	of	of	ADP
bam-7218	405	16	muscle	muscle	NOUN
bam-7218	405	17	mass	mass	PROPN
bam-7218	405	18	,	,	PUNCT
bam-7218	405	19	strength	strength	NOUN
bam-7218	405	20	and	and	CCONJ
bam-7218	405	21	function	function	NOUN
bam-7218	405	22	,	,	PUNCT
bam-7218	405	23	associated	associate	VERB
bam-7218	405	24	to	to	ADP
bam-7218	405	25	regenerative	regenerative	ADJ
bam-7218	405	26	difficulties	difficulty	NOUN
bam-7218	405	27	by	by	ADP
bam-7218	405	28	satellite	satellite	NOUN
bam-7218	405	29	cells	cell	NOUN
bam-7218	405	30	(	(	PUNCT
bam-7218	405	31	scs	scs	ADJ
bam-7218	405	32	)	)	PUNCT
bam-7218	405	33	,	,	PUNCT
bam-7218	405	34	adult	adult	NOUN
bam-7218	405	35	muscle	muscle	NOUN
bam-7218	405	36	stem	stem	NOUN
bam-7218	405	37	cells	cell	NOUN
bam-7218	405	38	.	.	PUNCT
bam-7218	406	1	the	the	DET
bam-7218	406	2	oxidative	oxidative	ADJ
bam-7218	406	3	stress	stress	NOUN
bam-7218	406	4	and	and	CCONJ
bam-7218	406	5	mitochondrial	mitochondrial	ADJ
bam-7218	406	6	dysfunction	dysfunction	NOUN
bam-7218	406	7	are	be	AUX
bam-7218	406	8	closely	closely	ADV
bam-7218	406	9	linked	link	VERB
bam-7218	406	10	.	.	PUNCT
bam-7218	407	1	the	the	DET
bam-7218	407	2	aim	aim	NOUN
bam-7218	407	3	of	of	ADP
bam-7218	407	4	this	this	DET
bam-7218	407	5	study	study	NOUN
bam-7218	407	6	was	be	AUX
bam-7218	407	7	to	to	PART
bam-7218	407	8	investigate	investigate	VERB
bam-7218	407	9	the	the	DET
bam-7218	407	10	metabolic	metabolic	NOUN
bam-7218	407	11	profile	profile	NOUN
bam-7218	407	12	of	of	ADP
bam-7218	407	13	young	young	ADJ
bam-7218	407	14	and	and	CCONJ
bam-7218	407	15	aged	aged	ADJ
bam-7218	407	16	mitochondria	mitochondria	NOUN
bam-7218	407	17	in	in	ADP
bam-7218	407	18	scs	scs	PROPN
bam-7218	407	19	isolated	isolate	VERB
bam-7218	407	20	from	from	ADP
bam-7218	407	21	human	human	ADJ
bam-7218	407	22	vastus	vastus	NOUN
bam-7218	407	23	lateralis	lateralis	VERB
bam-7218	407	24	skeletal	skeletal	ADJ
bam-7218	407	25	muscles	muscle	NOUN
bam-7218	407	26	of	of	ADP
bam-7218	407	27	young	young	ADJ
bam-7218	407	28	(	(	PUNCT
bam-7218	407	29	20	20	NUM
bam-7218	407	30	-	-	SYM
bam-7218	407	31	35	35	NUM
bam-7218	407	32	y	y	NOUN
bam-7218	407	33	)	)	PUNCT
bam-7218	407	34	and	and	CCONJ
bam-7218	407	35	elderly	elderly	ADJ
bam-7218	407	36	(	(	PUNCT
bam-7218	407	37	65	65	NUM
bam-7218	407	38	-	-	SYM
bam-7218	407	39	80	80	NUM
bam-7218	407	40	y	y	NOUN
bam-7218	407	41	)	)	PUNCT
bam-7218	407	42	subjects	subject	NOUN
bam-7218	407	43	,	,	PUNCT
bam-7218	407	44	correlating	correlate	VERB
bam-7218	407	45	with	with	ADP
bam-7218	407	46	ros	ros	PROPN
bam-7218	407	47	production	production	NOUN
bam-7218	407	48	.	.	PUNCT
bam-7218	408	1	the	the	DET
bam-7218	408	2	mitochondrial	mitochondrial	ADJ
bam-7218	408	3	superoxide	superoxide	NOUN
bam-7218	408	4	anion	anion	NOUN
bam-7218	408	5	(	(	PUNCT
bam-7218	408	6	o2•-	o2•-	NOUN
bam-7218	408	7	)	)	PUNCT
bam-7218	408	8	production	production	NOUN
bam-7218	408	9	on	on	ADP
bam-7218	408	10	myoblasts	myoblast	NOUN
bam-7218	408	11	and	and	CCONJ
bam-7218	408	12	myotubes	myotube	NOUN
bam-7218	408	13	was	be	AUX
bam-7218	408	14	assessed	assess	VERB
bam-7218	408	15	with	with	ADP
bam-7218	408	16	mitosox	mitosox	ADJ
bam-7218	408	17	red	red	ADJ
bam-7218	408	18	probe	probe	NOUN
bam-7218	408	19	.	.	PUNCT
bam-7218	409	1	it	it	PRON
bam-7218	409	2	was	be	AUX
bam-7218	409	3	performed	perform	VERB
bam-7218	409	4	in	in	ADP
bam-7218	409	5	the	the	DET
bam-7218	409	6	presence	presence	NOUN
bam-7218	409	7	of	of	ADP
bam-7218	409	8	anti	anti	ADJ
bam-7218	409	9	-	-	ADJ
bam-7218	409	10	oxidant	oxidant	ADJ
bam-7218	409	11	n	n	CCONJ
bam-7218	409	12	-	-	PUNCT
bam-7218	409	13	acetylcysteine	acetylcysteine	NOUN
bam-7218	409	14	(	(	PUNCT
bam-7218	409	15	nac	nac	PROPN
bam-7218	409	16	)	)	PUNCT
bam-7218	409	17	or	or	CCONJ
bam-7218	409	18	glucose	glucose	NOUN
bam-7218	409	19	and	and	CCONJ
bam-7218	409	20	sodium	sodium	NOUN
bam-7218	409	21	pyruvate	pyruvate	NOUN
bam-7218	409	22	(	(	PUNCT
bam-7218	409	23	burst	burst	NOUN
bam-7218	409	24	)	)	PUNCT
bam-7218	409	25	.	.	PUNCT
bam-7218	410	1	young	young	ADJ
bam-7218	410	2	myoblasts	myoblast	NOUN
bam-7218	410	3	with	with	ADP
bam-7218	410	4	nac	nac	PROPN
bam-7218	410	5	and	and	CCONJ
bam-7218	410	6	burst	burst	PROPN
bam-7218	410	7	presented	present	VERB
bam-7218	410	8	a	a	DET
bam-7218	410	9	significant	significant	ADJ
bam-7218	410	10	reduction	reduction	NOUN
bam-7218	410	11	of	of	ADP
bam-7218	410	12	o2•levels	o2•levels	PROPN
bam-7218	410	13	.	.	PUNCT
bam-7218	411	1	in	in	ADP
bam-7218	411	2	elderly	elderly	ADJ
bam-7218	411	3	myoblasts	myoblast	NOUN
bam-7218	411	4	,	,	PUNCT
bam-7218	411	5	both	both	DET
bam-7218	411	6	treatments	treatment	NOUN
bam-7218	411	7	did	do	AUX
bam-7218	411	8	not	not	PART
bam-7218	411	9	give	give	VERB
bam-7218	411	10	effects	effect	NOUN
bam-7218	411	11	while	while	SCONJ
bam-7218	411	12	elderly	elderly	ADJ
bam-7218	411	13	myotubes	myotube	NOUN
bam-7218	411	14	increased	increase	VERB
bam-7218	411	15	o2•	o2•	ADJ
bam-7218	411	16	levels	level	NOUN
bam-7218	411	17	.	.	PUNCT
bam-7218	412	1	the	the	DET
bam-7218	412	2	seahorse	seahorse	NOUN
bam-7218	412	3	analyzer	analyzer	NOUN
bam-7218	412	4	measures	measure	VERB
bam-7218	412	5	the	the	DET
bam-7218	412	6	oxygen	oxygen	NOUN
bam-7218	412	7	consumption	consumption	NOUN
bam-7218	412	8	rate	rate	NOUN
bam-7218	412	9	(	(	PUNCT
bam-7218	412	10	ocr	ocr	NOUN
bam-7218	412	11	)	)	PUNCT
bam-7218	412	12	and	and	CCONJ
bam-7218	412	13	the	the	DET
bam-7218	412	14	extracellular	extracellular	ADJ
bam-7218	412	15	acidification	acidification	NOUN
bam-7218	412	16	rate	rate	NOUN
bam-7218	412	17	(	(	PUNCT
bam-7218	412	18	ecar	ecar	NOUN
bam-7218	412	19	)	)	PUNCT
bam-7218	412	20	.	.	PUNCT
bam-7218	413	1	the	the	DET
bam-7218	413	2	basal	basal	NOUN
bam-7218	413	3	and	and	CCONJ
bam-7218	413	4	the	the	DET
bam-7218	413	5	maximal	maximal	ADJ
bam-7218	413	6	ocr	ocr	NOUN
bam-7218	413	7	in	in	ADP
bam-7218	413	8	elderly	elderly	ADJ
bam-7218	413	9	myoblasts	myoblast	NOUN
bam-7218	413	10	were	be	AUX
bam-7218	413	11	lower	low	ADJ
bam-7218	413	12	respect	respect	NOUN
bam-7218	413	13	to	to	ADP
bam-7218	413	14	the	the	DET
bam-7218	413	15	young	young	ADJ
bam-7218	413	16	ones	one	NOUN
bam-7218	413	17	independently	independently	ADV
bam-7218	413	18	from	from	ADP
bam-7218	413	19	nac	nac	PROPN
bam-7218	413	20	.	.	PUNCT
bam-7218	414	1	in	in	ADP
bam-7218	414	2	presence	presence	NOUN
bam-7218	414	3	of	of	ADP
bam-7218	414	4	nac	nac	PROPN
bam-7218	414	5	elderly	elderly	ADJ
bam-7218	414	6	myotubes	myotube	NOUN
bam-7218	414	7	were	be	AUX
bam-7218	414	8	affected	affect	VERB
bam-7218	414	9	.	.	PUNCT
bam-7218	415	1	the	the	DET
bam-7218	415	2	spare	spare	ADJ
bam-7218	415	3	respiratory	respiratory	ADJ
bam-7218	415	4	capacity	capacity	NOUN
bam-7218	415	5	and	and	CCONJ
bam-7218	415	6	the	the	DET
bam-7218	415	7	atp	atp	NOUN
bam-7218	415	8	-	-	PUNCT
bam-7218	415	9	linked	link	VERB
bam-7218	415	10	ocr	ocr	PROPN
bam-7218	415	11	were	be	AUX
bam-7218	415	12	impaired	impair	VERB
bam-7218	415	13	only	only	ADV
bam-7218	415	14	in	in	ADP
bam-7218	415	15	elderly	elderly	ADJ
bam-7218	415	16	myoblasts	myoblast	NOUN
bam-7218	415	17	independently	independently	ADV
bam-7218	415	18	from	from	ADP
bam-7218	415	19	nac	nac	PROPN
bam-7218	415	20	.	.	PUNCT
bam-7218	416	1	the	the	DET
bam-7218	416	2	glycolytic	glycolytic	ADJ
bam-7218	416	3	parameters	parameter	NOUN
bam-7218	416	4	were	be	AUX
bam-7218	416	5	higher	high	ADJ
bam-7218	416	6	in	in	ADP
bam-7218	416	7	young	young	ADJ
bam-7218	416	8	myoblasts	myoblast	NOUN
bam-7218	416	9	compared	compare	VERB
bam-7218	416	10	to	to	ADP
bam-7218	416	11	elderly	elderly	ADJ
bam-7218	416	12	ones	one	NOUN
bam-7218	416	13	while	while	SCONJ
bam-7218	416	14	an	an	DET
bam-7218	416	15	opposite	opposite	ADJ
bam-7218	416	16	situation	situation	NOUN
bam-7218	416	17	observed	observe	VERB
bam-7218	416	18	in	in	ADP
bam-7218	416	19	myotubes	myotube	NOUN
bam-7218	416	20	.	.	PUNCT
bam-7218	417	1	in	in	ADP
bam-7218	417	2	conclusion	conclusion	NOUN
bam-7218	417	3	we	we	PRON
bam-7218	417	4	demonstrated	demonstrate	VERB
bam-7218	417	5	that	that	SCONJ
bam-7218	417	6	elderly	elderly	ADJ
bam-7218	417	7	muscle	muscle	NOUN
bam-7218	417	8	cells	cell	NOUN
bam-7218	417	9	are	be	AUX
bam-7218	417	10	unable	unable	ADJ
bam-7218	417	11	to	to	PART
bam-7218	417	12	handle	handle	VERB
bam-7218	417	13	high	high	ADJ
bam-7218	417	14	glucose	glucose	NOUN
bam-7218	417	15	concentrations	concentration	NOUN
bam-7218	417	16	that	that	PRON
bam-7218	417	17	is	be	AUX
bam-7218	417	18	associated	associate	VERB
bam-7218	417	19	to	to	ADP
bam-7218	417	20	impaired	impaired	ADJ
bam-7218	417	21	mitochondrial	mitochondrial	ADJ
bam-7218	417	22	function	function	NOUN
bam-7218	417	23	resulting	result	VERB
bam-7218	417	24	in	in	ADP
bam-7218	417	25	high	high	ADJ
bam-7218	417	26	ros	ros	PROPN
bam-7218	417	27	levels	level	NOUN
bam-7218	417	28	.	.	PUNCT
bam-7218	418	1	3.5	3.5	NUM
bam-7218	418	2	molecular	molecular	ADJ
bam-7218	418	3	and	and	CCONJ
bam-7218	418	4	cellular	cellular	ADJ
bam-7218	418	5	mechanisms	mechanism	NOUN
bam-7218	418	6	regulating	regulate	VERB
bam-7218	418	7	satellite	satellite	NOUN
bam-7218	418	8	cell	cell	NOUN
bam-7218	418	9	quiescence	quiescence	NOUN
bam-7218	418	10	and	and	CCONJ
bam-7218	418	11	growth	growth	NOUN
bam-7218	418	12	arrest	arrest	NOUN
bam-7218	418	13	frederic	frederic	PROPN
bam-7218	418	14	relaix	relaix	PROPN
bam-7218	418	15	imrb	imrb	PROPN
bam-7218	418	16	inserm	inserm	VERB
bam-7218	418	17	u955	u955	NUM
bam-7218	418	18	-	-	PUNCT
bam-7218	418	19	e10	e10	PROPN
bam-7218	418	20	bnms	bnms	NOUN
bam-7218	418	21	team	team	NOUN
bam-7218	418	22	,	,	PUNCT
bam-7218	418	23	université	université	PROPN
bam-7218	418	24	paris	paris	PROPN
bam-7218	418	25	-	-	PUNCT
bam-7218	418	26	est	est	PROPN
bam-7218	418	27	creteil	creteil	PROPN
bam-7218	418	28	,	,	PUNCT
bam-7218	418	29	france	france	PROPN
bam-7218	418	30	.	.	PUNCT
bam-7218	419	1	e	e	X
bam-7218	419	2	-	-	NOUN
bam-7218	419	3	mail	mail	NOUN
bam-7218	419	4	:	:	PUNCT
bam-7218	419	5	frederic.relaix@inserm.fr	frederic.relaix@inserm.fr	VERB
bam-7218	419	6	a	a	DET
bam-7218	419	7	major	major	ADJ
bam-7218	419	8	challenge	challenge	NOUN
bam-7218	419	9	in	in	ADP
bam-7218	419	10	the	the	DET
bam-7218	419	11	muscle	muscle	NOUN
bam-7218	419	12	field	field	NOUN
bam-7218	419	13	is	be	AUX
bam-7218	419	14	to	to	PART
bam-7218	419	15	understand	understand	VERB
bam-7218	419	16	how	how	SCONJ
bam-7218	419	17	growth	growth	NOUN
bam-7218	419	18	arrest	arrest	NOUN
bam-7218	419	19	is	be	AUX
bam-7218	419	20	coordinated	coordinate	VERB
bam-7218	419	21	in	in	ADP
bam-7218	419	22	satellite	satellite	NOUN
bam-7218	419	23	cells	cell	NOUN
bam-7218	419	24	(	(	PUNCT
bam-7218	419	25	i.e.	i.e.	X
bam-7218	419	26	muscle	muscle	NOUN
bam-7218	419	27	stem	stem	NOUN
bam-7218	419	28	cells	cell	NOUN
bam-7218	419	29	)	)	PUNCT
bam-7218	419	30	during	during	ADP
bam-7218	419	31	muscle	muscle	NOUN
bam-7218	419	32	homeostasis	homeostasis	NOUN
bam-7218	419	33	/	/	SYM
bam-7218	419	34	maintenance	maintenance	NOUN
bam-7218	419	35	and	and	CCONJ
bam-7218	419	36	repair	repair	NOUN
bam-7218	419	37	.	.	PUNCT
bam-7218	420	1	skeletal	skeletal	ADJ
bam-7218	420	2	muscle	muscle	NOUN
bam-7218	420	3	shows	show	VERB
bam-7218	420	4	a	a	DET
bam-7218	420	5	remarkable	remarkable	ADJ
bam-7218	420	6	capacity	capacity	NOUN
bam-7218	420	7	to	to	PART
bam-7218	420	8	regenerate	regenerate	VERB
bam-7218	420	9	after	after	ADP
bam-7218	420	10	severe	severe	ADJ
bam-7218	420	11	injuries	injury	NOUN
bam-7218	420	12	,	,	PUNCT
bam-7218	420	13	which	which	PRON
bam-7218	420	14	is	be	AUX
bam-7218	420	15	attributed	attribute	VERB
bam-7218	420	16	to	to	ADP
bam-7218	420	17	its	its	PRON
bam-7218	420	18	satellite	satellite	NOUN
bam-7218	420	19	cell	cell	NOUN
bam-7218	420	20	population	population	NOUN
bam-7218	420	21	.	.	PUNCT
bam-7218	421	1	once	once	ADV
bam-7218	421	2	muscle	muscle	NOUN
bam-7218	421	3	growth	growth	NOUN
bam-7218	421	4	is	be	AUX
bam-7218	421	5	completed	complete	VERB
bam-7218	421	6	at	at	ADP
bam-7218	421	7	early	early	ADJ
bam-7218	421	8	postnatal	postnatal	ADJ
bam-7218	421	9	life	life	NOUN
bam-7218	421	10	,	,	PUNCT
bam-7218	421	11	this	this	DET
bam-7218	421	12	stem	stem	NOUN
bam-7218	421	13	cell	cell	NOUN
bam-7218	421	14	population	population	NOUN
bam-7218	421	15	enters	enter	VERB
bam-7218	421	16	into	into	ADP
bam-7218	421	17	a	a	DET
bam-7218	421	18	non	non	ADJ
bam-7218	421	19	-	-	ADJ
bam-7218	421	20	cycling	cycling	ADJ
bam-7218	421	21	,	,	PUNCT
bam-7218	421	22	quiescent	quiescent	ADJ
bam-7218	421	23	state	state	NOUN
bam-7218	421	24	.	.	PUNCT
bam-7218	422	1	however	however	ADV
bam-7218	422	2	,	,	PUNCT
bam-7218	422	3	in	in	ADP
bam-7218	422	4	response	response	NOUN
bam-7218	422	5	to	to	ADP
bam-7218	422	6	specific	specific	ADJ
bam-7218	422	7	needs	need	NOUN
bam-7218	422	8	,	,	PUNCT
bam-7218	422	9	such	such	ADJ
bam-7218	422	10	as	as	ADP
bam-7218	422	11	injury	injury	NOUN
bam-7218	422	12	,	,	PUNCT
bam-7218	422	13	it	it	PRON
bam-7218	422	14	is	be	AUX
bam-7218	422	15	rapidly	rapidly	ADV
bam-7218	422	16	activated	activate	VERB
bam-7218	422	17	to	to	PART
bam-7218	422	18	provide	provide	VERB
bam-7218	422	19	differentiated	differentiated	ADJ
bam-7218	422	20	progeny	progeny	NOUN
bam-7218	422	21	for	for	ADP
bam-7218	422	22	muscle	muscle	NOUN
bam-7218	422	23	repair	repair	NOUN
bam-7218	422	24	as	as	ADV
bam-7218	422	25	well	well	ADV
bam-7218	422	26	as	as	ADP
bam-7218	422	27	to	to	AUX
bam-7218	422	28	self	self	NOUN
bam-7218	422	29	-	-	PUNCT
bam-7218	422	30	renew	renew	VERB
bam-7218	422	31	the	the	DET
bam-7218	422	32	quiescent	quiescent	ADJ
bam-7218	422	33	pool	pool	NOUN
bam-7218	422	34	.	.	PUNCT
bam-7218	423	1	we	we	PRON
bam-7218	423	2	have	have	AUX
bam-7218	423	3	designed	design	VERB
bam-7218	423	4	a	a	DET
bam-7218	423	5	protocol	protocol	NOUN
bam-7218	423	6	to	to	PART
bam-7218	423	7	isolate	isolate	VERB
bam-7218	423	8	the	the	DET
bam-7218	423	9	satellite	satellite	NOUN
bam-7218	423	10	cells	cell	NOUN
bam-7218	423	11	following	follow	VERB
bam-7218	423	12	direct	direct	ADJ
bam-7218	423	13	fixation	fixation	NOUN
bam-7218	423	14	and	and	CCONJ
bam-7218	423	15	defined	define	VERB
bam-7218	423	16	molecularly	molecularly	ADV
bam-7218	423	17	the	the	DET
bam-7218	423	18	early	early	ADJ
bam-7218	423	19	activation	activation	NOUN
bam-7218	423	20	following	follow	VERB
bam-7218	423	21	exit	exit	NOUN
bam-7218	423	22	from	from	ADP
bam-7218	423	23	quiescence	quiescence	NOUN
bam-7218	423	24	.	.	PUNCT
bam-7218	424	1	in	in	ADP
bam-7218	424	2	addition	addition	NOUN
bam-7218	424	3	,	,	PUNCT
bam-7218	424	4	muscle	muscle	NOUN
bam-7218	424	5	differentiation	differentiation	NOUN
bam-7218	424	6	is	be	AUX
bam-7218	424	7	a	a	DET
bam-7218	424	8	coordinated	coordinated	ADJ
bam-7218	424	9	process	process	NOUN
bam-7218	424	10	of	of	ADP
bam-7218	424	11	tissue	tissue	NOUN
bam-7218	424	12	-	-	PUNCT
bam-7218	424	13	specific	specific	ADJ
bam-7218	424	14	gene	gene	NOUN
bam-7218	424	15	expression	expression	NOUN
bam-7218	424	16	and	and	CCONJ
bam-7218	424	17	irreversible	irreversible	ADJ
bam-7218	424	18	cell	cell	NOUN
bam-7218	424	19	cycle	cycle	NOUN
bam-7218	424	20	exit	exit	NOUN
bam-7218	424	21	.	.	PUNCT
bam-7218	425	1	we	we	PRON
bam-7218	425	2	have	have	AUX
bam-7218	425	3	analysed	analyse	VERB
bam-7218	425	4	the	the	DET
bam-7218	425	5	mechanism	mechanism	NOUN
bam-7218	425	6	of	of	ADP
bam-7218	425	7	growth	growth	NOUN
bam-7218	425	8	arrest	arrest	NOUN
bam-7218	425	9	during	during	ADP
bam-7218	425	10	terminal	terminal	ADJ
bam-7218	425	11	differentiation	differentiation	NOUN
bam-7218	425	12	,	,	PUNCT
bam-7218	425	13	including	include	VERB
bam-7218	425	14	the	the	DET
bam-7218	425	15	role	role	NOUN
bam-7218	425	16	of	of	ADP
bam-7218	425	17	cyclin	cyclin	PROPN
bam-7218	425	18	dependent	dependent	PROPN
bam-7218	425	19	kinase	kinase	PROPN
bam-7218	425	20	inhibitors	inhibitor	NOUN
bam-7218	425	21	p21	p21	NOUN
bam-7218	425	22	and	and	CCONJ
bam-7218	425	23	p57	p57	NOUN
bam-7218	425	24	.	.	PUNCT
bam-7218	426	1	we	we	PRON
bam-7218	426	2	will	will	AUX
bam-7218	426	3	present	present	VERB
bam-7218	426	4	data	datum	NOUN
bam-7218	426	5	regarding	regard	VERB
bam-7218	426	6	p57	p57	NOUN
bam-7218	426	7	and	and	CCONJ
bam-7218	426	8	p21	p21	NOUN
bam-7218	426	9	expression	expression	NOUN
bam-7218	426	10	and	and	CCONJ
bam-7218	426	11	function	function	NOUN
bam-7218	426	12	ex	ex	PRON
bam-7218	426	13	vivo	vivo	NOUN
bam-7218	426	14	and	and	CCONJ
bam-7218	426	15	in	in	ADP
bam-7218	426	16	vivo	vivo	NOUN
bam-7218	426	17	,	,	PUNCT
bam-7218	426	18	in	in	ADP
bam-7218	426	19	adult	adult	NOUN
bam-7218	426	20	myofiber	myofiber	NOUN
bam-7218	426	21	culture	culture	NOUN
bam-7218	426	22	and	and	CCONJ
bam-7218	426	23	regeneration	regeneration	NOUN
bam-7218	426	24	models	model	NOUN
bam-7218	426	25	.	.	PUNCT
bam-7218	427	1	3.6	3.6	NUM
bam-7218	427	2	tissue	tissue	NOUN
bam-7218	427	3	engineering	engineering	NOUN
bam-7218	427	4	of	of	ADP
bam-7218	427	5	skeletal	skeletal	ADJ
bam-7218	427	6	muscle	muscle	NOUN
bam-7218	427	7	for	for	ADP
bam-7218	427	8	regenerative	regenerative	ADJ
bam-7218	427	9	medicine	medicine	NOUN
bam-7218	427	10	strategies	strategy	NOUN
bam-7218	427	11	anna	anna	PROPN
bam-7218	427	12	urciuolo	urciuolo	PROPN
bam-7218	427	13	(	(	PUNCT
bam-7218	427	14	a	a	DET
bam-7218	427	15	,	,	PUNCT
bam-7218	427	16	b	b	NOUN
bam-7218	427	17	)	)	PUNCT
bam-7218	427	18	,	,	PUNCT
bam-7218	427	19	elena	elena	PROPN
bam-7218	427	20	serena	serena	PROPN
bam-7218	427	21	(	(	PUNCT
bam-7218	427	22	a	a	NOUN
bam-7218	427	23	)	)	PUNCT
bam-7218	427	24	,	,	PUNCT
bam-7218	427	25	luca	luca	PROPN
bam-7218	427	26	urbani	urbani	PROPN
bam-7218	427	27	(	(	PUNCT
bam-7218	427	28	b	b	NOUN
bam-7218	427	29	)	)	PUNCT
bam-7218	427	30	,	,	PUNCT
bam-7218	427	31	silvia	silvia	PROPN
bam-7218	427	32	perin	perin	PROPN
bam-7218	427	33	(	(	PUNCT
bam-7218	427	34	b	b	NOUN
bam-7218	427	35	)	)	PUNCT
bam-7218	427	36	,	,	PUNCT
bam-7218	427	37	libero	libero	PROPN
bam-7218	427	38	vitiello	vitiello	PROPN
bam-7218	427	39	(	(	PUNCT
bam-7218	427	40	c	c	NOUN
bam-7218	427	41	)	)	PUNCT
bam-7218	427	42	,	,	PUNCT
bam-7218	427	43	bert	bert	PROPN
bam-7218	427	44	blaauw	blaauw	NOUN
bam-7218	427	45	(	(	PUNCT
bam-7218	427	46	a	a	X
bam-7218	427	47	)	)	PUNCT
bam-7218	427	48	,	,	PUNCT
bam-7218	427	49	paolo	paolo	PROPN
bam-7218	427	50	de	de	X
bam-7218	427	51	coppi	coppi	PROPN
bam-7218	427	52	(	(	PUNCT
bam-7218	427	53	b	b	NOUN
bam-7218	427	54	)	)	PUNCT
bam-7218	427	55	,	,	PUNCT
bam-7218	427	56	nicola	nicola	PROPN
bam-7218	427	57	elavassore	elavassore	ADV
bam-7218	427	58	(	(	PUNCT
bam-7218	427	59	a	a	DET
bam-7218	427	60	,	,	PUNCT
bam-7218	427	61	b	b	NOUN
bam-7218	427	62	)	)	PUNCT
bam-7218	427	63	(	(	PUNCT
bam-7218	427	64	a	a	X
bam-7218	427	65	)	)	PUNCT
bam-7218	427	66	venetian	venetian	ADJ
bam-7218	427	67	institute	institute	NOUN
bam-7218	427	68	of	of	ADP
bam-7218	427	69	molecular	molecular	ADJ
bam-7218	427	70	medicine	medicine	NOUN
bam-7218	427	71	,	,	PUNCT
bam-7218	427	72	padova	padova	PROPN
bam-7218	427	73	,	,	PUNCT
bam-7218	427	74	italy	italy	PROPN
bam-7218	427	75	;	;	PUNCT
bam-7218	427	76	
	
	SPACE
bam-7218	427	77	(	(	PUNCT
bam-7218	427	78	b	b	NOUN
bam-7218	427	79	)	)	PUNCT
bam-7218	427	80	stem	stem	NOUN
bam-7218	427	81	cells	cell	NOUN
bam-7218	427	82	&	&	CCONJ
bam-7218	427	83	regenerative	regenerative	ADJ
bam-7218	427	84	medicine	medicine	NOUN
bam-7218	427	85	section	section	NOUN
bam-7218	427	86	,	,	PUNCT
bam-7218	427	87	institute	institute	NOUN
bam-7218	427	88	of	of	ADP
bam-7218	427	89	child	child	PROPN
bam-7218	427	90	health	health	PROPN
bam-7218	427	91	ucl	ucl	PROPN
bam-7218	427	92	,	,	PUNCT
bam-7218	427	93	london	london	PROPN
bam-7218	427	94	,	,	PUNCT
bam-7218	427	95	uk	uk	PROPN
bam-7218	427	96	;	;	PUNCT
bam-7218	427	97	(	(	PUNCT
bam-7218	427	98	c	c	X
bam-7218	427	99	)	)	PUNCT
bam-7218	427	100	dept	dept	NOUN
bam-7218	427	101	of	of	ADP
bam-7218	427	102	biology	biology	NOUN
bam-7218	427	103	,	,	PUNCT
bam-7218	427	104	university	university	NOUN
bam-7218	427	105	of	of	ADP
bam-7218	427	106	padova	padova	PROPN
bam-7218	427	107	,	,	PUNCT
bam-7218	427	108	italy	italy	PROPN
bam-7218	427	109	.	.	PUNCT
bam-7218	428	1	e	e	X
bam-7218	428	2	-	-	NOUN
bam-7218	428	3	mail	mail	NOUN
bam-7218	428	4	:	:	PUNCT
bam-7218	428	5	anna.urciuolo@unipd.it	anna.urciuolo@unipd.it	VERB
bam-7218	428	6	skeletal	skeletal	ADJ
bam-7218	428	7	muscle	muscle	NOUN
bam-7218	428	8	is	be	AUX
bam-7218	428	9	of	of	ADP
bam-7218	428	10	high	high	ADJ
bam-7218	428	11	clinical	clinical	ADJ
bam-7218	428	12	interest	interest	NOUN
bam-7218	428	13	since	since	SCONJ
bam-7218	428	14	many	many	ADJ
bam-7218	428	15	congenital	congenital	ADJ
bam-7218	428	16	or	or	CCONJ
bam-7218	428	17	acquired	acquire	VERB
bam-7218	428	18	conditions	condition	NOUN
bam-7218	428	19	can	can	AUX
bam-7218	428	20	affect	affect	VERB
bam-7218	428	21	its	its	PRON
bam-7218	428	22	function	function	NOUN
bam-7218	428	23	,	,	PUNCT
bam-7218	428	24	leading	lead	VERB
bam-7218	428	25	to	to	ADP
bam-7218	428	26	irreversible	irreversible	ADJ
bam-7218	428	27	loss	loss	NOUN
bam-7218	428	28	of	of	ADP
bam-7218	428	29	tissue	tissue	NOUN
bam-7218	428	30	–	–	PUNCT
bam-7218	428	31	volumetric	volumetric	ADJ
bam-7218	428	32	muscle	muscle	NOUN
bam-7218	428	33	loss	loss	NOUN
bam-7218	428	34	,	,	PUNCT
bam-7218	429	1	vml	vml	NOUN
bam-7218	429	2	.	.	PUNCT
bam-7218	429	3	tissue	tissue	NOUN
bam-7218	429	4	engineering	engineering	NOUN
bam-7218	429	5	aims	aim	VERB
bam-7218	429	6	to	to	PART
bam-7218	429	7	mimic	mimic	VERB
bam-7218	429	8	neoorganogenesis	neoorganogenesis	NOUN
bam-7218	429	9	for	for	ADP
bam-7218	429	10	producing	produce	VERB
bam-7218	429	11	tissues	tissue	NOUN
bam-7218	429	12	to	to	PART
bam-7218	429	13	be	be	AUX
bam-7218	429	14	applied	apply	VERB
bam-7218	429	15	in	in	ADP
bam-7218	429	16	regenerative	regenerative	ADJ
bam-7218	429	17	medicine	medicine	NOUN
bam-7218	429	18	,	,	PUNCT
bam-7218	429	19	and	and	CCONJ
bam-7218	429	20	holds	hold	VERB
bam-7218	429	21	great	great	ADJ
bam-7218	429	22	potential	potential	NOUN
bam-7218	429	23	for	for	ADP
bam-7218	429	24	the	the	DET
bam-7218	429	25	treatment	treatment	NOUN
bam-7218	429	26	of	of	ADP
bam-7218	429	27	incurable	incurable	ADJ
bam-7218	429	28	skeletal	skeletal	ADJ
bam-7218	429	29	muscle	muscle	NOUN
bam-7218	429	30	pathologies	pathology	NOUN
bam-7218	429	31	.	.	PUNCT
bam-7218	430	1	recent	recent	ADJ
bam-7218	430	2	translational	translational	ADJ
bam-7218	430	3	technologies	technology	NOUN
bam-7218	430	4	are	be	AUX
bam-7218	430	5	based	base	VERB
bam-7218	430	6	on	on	ADP
bam-7218	430	7	the	the	DET
bam-7218	430	8	use	use	NOUN
bam-7218	430	9	of	of	ADP
bam-7218	430	10	natural	natural	ADJ
bam-7218	430	11	or	or	CCONJ
bam-7218	430	12	synthetic	synthetic	ADJ
bam-7218	430	13	scaffolds	scaffold	NOUN
bam-7218	430	14	that	that	PRON
bam-7218	430	15	ideally	ideally	ADV
bam-7218	430	16	can	can	AUX
bam-7218	430	17	be	be	AUX
bam-7218	430	18	implanted	implant	VERB
bam-7218	430	19	in	in	ADP
bam-7218	430	20	patients	patient	NOUN
bam-7218	430	21	and	and	CCONJ
bam-7218	430	22	aid	aid	VERB
bam-7218	430	23	functional	functional	ADJ
bam-7218	430	24	maturation	maturation	NOUN
bam-7218	430	25	of	of	ADP
bam-7218	430	26	mailto:mariangela.marrone19@libero.it	mailto:mariangela.marrone19@libero.it	NUM
bam-7218	430	27	mailto:frederic.relaix@inserm.fr	mailto:frederic.relaix@inserm.fr	PROPN
bam-7218	430	28	mailto:anna.urciuolo@unipd.it	mailto:anna.urciuolo@unipd.it	PROPN
bam-7218	430	29	14	14	NUM
bam-7218	430	30	th	th	NOUN
bam-7218	430	31	iiim	iiim	NOUN
bam-7218	430	32	meeting	meeting	NOUN
bam-7218	430	33	,	,	PUNCT
bam-7218	430	34	assisi	assisi	PROPN
bam-7218	430	35	,	,	PUNCT
bam-7218	430	36	italy	italy	PROPN
bam-7218	430	37	october	october	PROPN
bam-7218	430	38	12	12	NUM
bam-7218	430	39	-	-	SYM
bam-7218	430	40	15	15	NUM
bam-7218	430	41	2017	2017	NUM
bam-7218	430	42	eur	eur	PROPN
bam-7218	430	43	j	j	PROPN
bam-7218	430	44	transl	transl	PROPN
bam-7218	430	45	myol	myol	ADV
bam-7218	430	46	27	27	NUM
bam-7218	430	47	(	(	PUNCT
bam-7218	430	48	4	4	NUM
bam-7218	430	49	):	):	SYM
bam-7218	430	50	185	185	NUM
bam-7218	430	51	-	-	SYM
bam-7218	430	52	224	224	NUM
bam-7218	430	53	197	197	NUM
bam-7218	430	54	skeletal	skeletal	ADJ
bam-7218	430	55	muscle	muscle	NOUN
bam-7218	430	56	in	in	ADP
bam-7218	430	57	vivo	vivo	NOUN
bam-7218	430	58	.	.	PUNCT
bam-7218	431	1	in	in	ADP
bam-7218	431	2	order	order	NOUN
bam-7218	431	3	to	to	PART
bam-7218	431	4	investigate	investigate	VERB
bam-7218	431	5	the	the	DET
bam-7218	431	6	real	real	ADJ
bam-7218	431	7	application	application	NOUN
bam-7218	431	8	of	of	ADP
bam-7218	431	9	such	such	ADJ
bam-7218	431	10	scaffolds	scaffold	NOUN
bam-7218	431	11	in	in	ADP
bam-7218	431	12	muscle	muscle	NOUN
bam-7218	431	13	regenerative	regenerative	ADJ
bam-7218	431	14	medicine	medicine	NOUN
bam-7218	431	15	,	,	PUNCT
bam-7218	431	16	vml	vml	PROPN
bam-7218	431	17	mouse	mouse	NOUN
bam-7218	431	18	models	model	NOUN
bam-7218	431	19	were	be	AUX
bam-7218	431	20	generated	generate	VERB
bam-7218	431	21	for	for	ADP
bam-7218	431	22	extensor	extensor	NOUN
bam-7218	431	23	digitorum	digitorum	PROPN
bam-7218	431	24	longus	longus	PROPN
bam-7218	431	25	(	(	PUNCT
bam-7218	431	26	edl	edl	PROPN
bam-7218	431	27	)	)	PUNCT
bam-7218	431	28	and	and	CCONJ
bam-7218	431	29	tibialis	tibialis	PROPN
bam-7218	431	30	anterior	anterior	NOUN
bam-7218	431	31	(	(	PUNCT
bam-7218	431	32	ta	ta	NOUN
bam-7218	431	33	)	)	PUNCT
bam-7218	431	34	muscles	muscle	NOUN
bam-7218	431	35	.	.	PUNCT
bam-7218	432	1	decellularised	decellularise	VERB
bam-7218	432	2	rat	rat	NOUN
bam-7218	432	3	edl	edl	PROPN
bam-7218	432	4	were	be	AUX
bam-7218	432	5	used	use	VERB
bam-7218	432	6	to	to	PART
bam-7218	432	7	rescue	rescue	VERB
bam-7218	432	8	the	the	DET
bam-7218	432	9	vml	vml	NOUN
bam-7218	432	10	of	of	ADP
bam-7218	432	11	90	90	NUM
bam-7218	432	12	%	%	NOUN
bam-7218	432	13	edl	edl	PROPN
bam-7218	432	14	ablation	ablation	NOUN
bam-7218	432	15	,	,	PUNCT
bam-7218	432	16	while	while	SCONJ
bam-7218	432	17	a	a	DET
bam-7218	432	18	synthetic	synthetic	ADJ
bam-7218	432	19	photo	photo	NOUN
bam-7218	432	20	-	-	PUNCT
bam-7218	432	21	crosslinkable	crosslinkable	ADJ
bam-7218	432	22	biomaterial	biomaterial	NOUN
bam-7218	432	23	was	be	AUX
bam-7218	432	24	used	use	VERB
bam-7218	432	25	for	for	ADP
bam-7218	432	26	repairing	repair	VERB
bam-7218	432	27	30	30	NUM
bam-7218	432	28	%	%	NOUN
bam-7218	432	29	ta	ta	PART
bam-7218	432	30	ablation	ablation	NOUN
bam-7218	432	31	.	.	PUNCT
bam-7218	433	1	scaffolds	scaffold	NOUN
bam-7218	433	2	materials	material	NOUN
bam-7218	433	3	were	be	AUX
bam-7218	433	4	able	able	ADJ
bam-7218	433	5	to	to	PART
bam-7218	433	6	be	be	AUX
bam-7218	433	7	repopulated	repopulate	VERB
bam-7218	433	8	by	by	ADP
bam-7218	433	9	recipient	recipient	NOUN
bam-7218	433	10	cells	cell	NOUN
bam-7218	433	11	and	and	CCONJ
bam-7218	433	12	supported	support	VERB
bam-7218	433	13	myogenesis	myogenesis	NOUN
bam-7218	433	14	and	and	CCONJ
bam-7218	433	15	functional	functional	ADJ
bam-7218	433	16	muscle	muscle	NOUN
bam-7218	433	17	formation	formation	NOUN
bam-7218	433	18	.	.	PUNCT
bam-7218	434	1	the	the	DET
bam-7218	434	2	preservation	preservation	NOUN
bam-7218	434	3	of	of	ADP
bam-7218	434	4	native	native	ADJ
bam-7218	434	5	ecm	ecm	PROPN
bam-7218	434	6	components	component	NOUN
bam-7218	434	7	and	and	CCONJ
bam-7218	434	8	3d	3d	NUM
bam-7218	434	9	organization	organization	NOUN
bam-7218	434	10	,	,	PUNCT
bam-7218	434	11	strongly	strongly	ADV
bam-7218	434	12	improved	improve	VERB
bam-7218	434	13	the	the	DET
bam-7218	434	14	ability	ability	NOUN
bam-7218	434	15	of	of	ADP
bam-7218	434	16	the	the	DET
bam-7218	434	17	scaffold	scaffold	NOUN
bam-7218	434	18	to	to	PART
bam-7218	434	19	support	support	VERB
bam-7218	434	20	myogenesis	myogenesis	NOUN
bam-7218	434	21	.	.	PUNCT
bam-7218	435	1	3.7	3.7	NUM
bam-7218	435	2	macrophages	macrophage	NOUN
bam-7218	435	3	as	as	ADP
bam-7218	435	4	regulators	regulator	NOUN
bam-7218	435	5	of	of	ADP
bam-7218	435	6	skeletal	skeletal	ADJ
bam-7218	435	7	muscle	muscle	NOUN
bam-7218	435	8	regeneration	regeneration	NOUN
bam-7218	435	9	:	:	PUNCT
bam-7218	435	10	factors	factor	NOUN
bam-7218	435	11	secreted	secrete	VERB
bam-7218	435	12	by	by	ADP
bam-7218	435	13	murine	murine	ADJ
bam-7218	435	14	j774	j774	PROPN
bam-7218	435	15	cells	cell	NOUN
bam-7218	435	16	affect	affect	VERB
bam-7218	435	17	proliferation	proliferation	NOUN
bam-7218	435	18	,	,	PUNCT
bam-7218	435	19	differentiation	differentiation	NOUN
bam-7218	435	20	and	and	CCONJ
bam-7218	435	21	survival	survival	NOUN
bam-7218	435	22	of	of	ADP
bam-7218	435	23	muscle	muscle	NOUN
bam-7218	435	24	stem	stem	NOUN
bam-7218	435	25	cells	cell	NOUN
bam-7218	435	26	and	and	CCONJ
bam-7218	435	27	fibro	fibro	PROPN
bam-7218	435	28	-	-	PUNCT
bam-7218	435	29	adipogenic	adipogenic	ADJ
bam-7218	435	30	progenitors	progenitor	NOUN
bam-7218	435	31	eva	eva	NOUN
bam-7218	435	32	galletta	galletta	NOUN
bam-7218	435	33	(	(	PUNCT
bam-7218	435	34	a	a	X
bam-7218	435	35	)	)	PUNCT
bam-7218	435	36	,	,	PUNCT
bam-7218	435	37	federica	federica	PROPN
bam-7218	435	38	de	de	PROPN
bam-7218	435	39	majo	majo	X
bam-7218	435	40	(	(	PUNCT
bam-7218	435	41	a	a	NOUN
bam-7218	435	42	)	)	PUNCT
bam-7218	435	43	,	,	PUNCT
bam-7218	435	44	lucia	lucia	PROPN
bam-7218	435	45	tibaudo	tibaudo	PROPN
bam-7218	435	46	(	(	PUNCT
bam-7218	435	47	a	a	NOUN
bam-7218	435	48	)	)	PUNCT
bam-7218	435	49	,	,	PUNCT
bam-7218	435	50	cesare	cesare	PROPN
bam-7218	435	51	gargioli	gargioli	PROPN
bam-7218	435	52	(	(	PUNCT
bam-7218	435	53	b	b	NOUN
bam-7218	435	54	)	)	PUNCT
bam-7218	435	55	,	,	PUNCT
bam-7218	435	56	giorgia	giorgia	PROPN
bam-7218	435	57	giacomazzi	giacomazzi	PROPN
bam-7218	435	58	(	(	PUNCT
bam-7218	435	59	c	c	NOUN
bam-7218	435	60	)	)	PUNCT
bam-7218	435	61	,	,	PUNCT
bam-7218	435	62	luca	luca	PROPN
bam-7218	435	63	madaro	madaro	NOUN
bam-7218	435	64	(	(	PUNCT
bam-7218	435	65	d	d	NOUN
bam-7218	435	66	)	)	PUNCT
bam-7218	435	67	,	,	PUNCT
bam-7218	435	68	serena	serena	PROPN
bam-7218	435	69	mandla	mandla	NOUN
bam-7218	435	70	(	(	PUNCT
bam-7218	435	71	e	e	NOUN
bam-7218	435	72	)	)	PUNCT
bam-7218	435	73	,	,	PUNCT
bam-7218	435	74	penney	penney	PROPN
bam-7218	435	75	gilbert	gilbert	PROPN
bam-7218	435	76	(	(	PUNCT
bam-7218	435	77	e	e	NOUN
bam-7218	435	78	)	)	PUNCT
bam-7218	435	79	,	,	PUNCT
bam-7218	435	80	libero	libero	PROPN
bam-7218	435	81	vitiello	vitiello	PROPN
bam-7218	435	82	(	(	PUNCT
bam-7218	435	83	a	a	NOUN
bam-7218	435	84	)	)	PUNCT
bam-7218	435	85	(	(	PUNCT
bam-7218	435	86	a	a	X
bam-7218	435	87	)	)	PUNCT
bam-7218	435	88	dept	dept	NOUN
bam-7218	435	89	of	of	ADP
bam-7218	435	90	biology	biology	NOUN
bam-7218	435	91	,	,	PUNCT
bam-7218	435	92	university	university	NOUN
bam-7218	435	93	of	of	ADP
bam-7218	435	94	padova	padova	PROPN
bam-7218	435	95	,	,	PUNCT
bam-7218	435	96	italy	italy	PROPN
bam-7218	435	97	;	;	PUNCT
bam-7218	435	98	(	(	PUNCT
bam-7218	435	99	b	b	X
bam-7218	435	100	)	)	PUNCT
bam-7218	435	101	dept	dept	NOUN
bam-7218	435	102	of	of	ADP
bam-7218	435	103	biology	biology	NOUN
bam-7218	435	104	,	,	PUNCT
bam-7218	435	105	university	university	NOUN
bam-7218	435	106	of	of	ADP
bam-7218	435	107	tor	tor	PROPN
bam-7218	435	108	vergata	vergata	PROPN
bam-7218	435	109	,	,	PUNCT
bam-7218	435	110	italy	italy	PROPN
bam-7218	435	111	;	;	PUNCT
bam-7218	435	112	(	(	PUNCT
bam-7218	435	113	c	c	X
bam-7218	435	114	)	)	PUNCT
bam-7218	435	115	stamcelinstituut	stamcelinstituut	NOUN
bam-7218	435	116	,	,	PUNCT
bam-7218	435	117	university	university	NOUN
bam-7218	435	118	of	of	ADP
bam-7218	435	119	leuven	leuven	PROPN
bam-7218	435	120	,	,	PUNCT
bam-7218	435	121	belgium	belgium	NOUN
bam-7218	435	122	;	;	PUNCT
bam-7218	435	123	(	(	PUNCT
bam-7218	435	124	d	d	X
bam-7218	435	125	)	)	PUNCT
bam-7218	435	126	epigenetics	epigenetic	NOUN
bam-7218	435	127	&	&	CCONJ
bam-7218	435	128	regenerative	regenerative	ADJ
bam-7218	435	129	pharmacology	pharmacology	NOUN
bam-7218	435	130	,	,	PUNCT
bam-7218	435	131	irccs	ircc	VERB
bam-7218	435	132	fondazione	fondazione	PROPN
bam-7218	435	133	santa	santa	PROPN
bam-7218	435	134	lucia	lucia	PROPN
bam-7218	435	135	,	,	PUNCT
bam-7218	435	136	italy	italy	PROPN
bam-7218	435	137	;	;	PUNCT
bam-7218	435	138	(	(	PUNCT
bam-7218	435	139	e	e	X
bam-7218	435	140	)	)	PUNCT
bam-7218	435	141	institute	institute	NOUN
bam-7218	435	142	of	of	ADP
bam-7218	435	143	biomaterials	biomaterial	NOUN
bam-7218	435	144	and	and	CCONJ
bam-7218	435	145	biomedical	biomedical	ADJ
bam-7218	435	146	engineering	engineering	NOUN
bam-7218	435	147	,	,	PUNCT
bam-7218	435	148	university	university	PROPN
bam-7218	435	149	of	of	ADP
bam-7218	435	150	toronto	toronto	PROPN
bam-7218	435	151	,	,	PUNCT
bam-7218	435	152	canada	canada	PROPN
bam-7218	435	153	.	.	PUNCT
bam-7218	436	1	e	e	X
bam-7218	436	2	-	-	NOUN
bam-7218	436	3	mail	mail	NOUN
bam-7218	436	4	:	:	PUNCT
bam-7218	436	5	libero.vitiello@unipd.it	libero.vitiello@unipd.it	NOUN
bam-7218	436	6	muscle	muscle	NOUN
bam-7218	436	7	regeneration	regeneration	NOUN
bam-7218	436	8	is	be	AUX
bam-7218	436	9	a	a	DET
bam-7218	436	10	complex	complex	ADJ
bam-7218	436	11	,	,	PUNCT
bam-7218	436	12	multi	multi	ADJ
bam-7218	436	13	-	-	ADJ
bam-7218	436	14	staged	stage	VERB
bam-7218	436	15	process	process	NOUN
bam-7218	436	16	in	in	ADP
bam-7218	436	17	which	which	PRON
bam-7218	436	18	macrophages	macrophage	NOUN
bam-7218	436	19	play	play	VERB
bam-7218	436	20	a	a	DET
bam-7218	436	21	fundamental	fundamental	ADJ
bam-7218	436	22	role	role	NOUN
bam-7218	436	23	not	not	PART
bam-7218	436	24	only	only	ADV
bam-7218	436	25	as	as	ADP
bam-7218	436	26	scavengers	scavenger	NOUN
bam-7218	436	27	of	of	ADP
bam-7218	436	28	damage	damage	NOUN
bam-7218	436	29	tissue	tissue	NOUN
bam-7218	436	30	but	but	CCONJ
bam-7218	436	31	also	also	ADV
bam-7218	436	32	as	as	ADP
bam-7218	436	33	modulators	modulator	NOUN
bam-7218	436	34	of	of	ADP
bam-7218	436	35	both	both	CCONJ
bam-7218	436	36	myogenic	myogenic	ADJ
bam-7218	436	37	and	and	CCONJ
bam-7218	436	38	non	non	ADJ
bam-7218	436	39	-	-	ADJ
bam-7218	436	40	myogenic	myogenic	ADJ
bam-7218	436	41	precursors	precursor	NOUN
bam-7218	436	42	.	.	PUNCT
bam-7218	437	1	to	to	PART
bam-7218	437	2	study	study	VERB
bam-7218	437	3	the	the	DET
bam-7218	437	4	effects	effect	NOUN
bam-7218	437	5	of	of	ADP
bam-7218	437	6	macrophage	macrophage	NOUN
bam-7218	437	7	-	-	PUNCT
bam-7218	437	8	released	release	VERB
bam-7218	437	9	factors	factor	NOUN
bam-7218	437	10	in	in	ADP
bam-7218	437	11	this	this	DET
bam-7218	437	12	context	context	NOUN
bam-7218	437	13	we	we	PRON
bam-7218	437	14	used	use	VERB
bam-7218	437	15	the	the	DET
bam-7218	437	16	murine	murine	ADJ
bam-7218	437	17	macrophage	macrophage	ADJ
bam-7218	437	18	cell	cell	NOUN
bam-7218	437	19	line	line	NOUN
bam-7218	437	20	j774	j774	PROPN
bam-7218	437	21	to	to	PART
bam-7218	437	22	obtain	obtain	VERB
bam-7218	437	23	highly	highly	ADV
bam-7218	437	24	active	active	ADJ
bam-7218	437	25	conditioned	condition	VERB
bam-7218	437	26	medium	medium	ADJ
bam-7218	437	27	(	(	PUNCT
bam-7218	437	28	mmcm	mmcm	NOUN
bam-7218	437	29	)	)	PUNCT
bam-7218	437	30	upon	upon	SCONJ
bam-7218	437	31	exposure	exposure	NOUN
bam-7218	437	32	to	to	ADP
bam-7218	437	33	lps	lps	PROPN
bam-7218	437	34	.	.	PUNCT
bam-7218	438	1	we	we	PRON
bam-7218	438	2	have	have	AUX
bam-7218	438	3	previously	previously	ADV
bam-7218	438	4	shown	show	VERB
bam-7218	438	5	that	that	SCONJ
bam-7218	438	6	mmcm	mmcm	NOUN
bam-7218	438	7	can	can	AUX
bam-7218	438	8	enhance	enhance	VERB
bam-7218	438	9	the	the	DET
bam-7218	438	10	proliferation	proliferation	NOUN
bam-7218	438	11	and	and	CCONJ
bam-7218	438	12	differentiation	differentiation	NOUN
bam-7218	438	13	of	of	ADP
bam-7218	438	14	rat	rat	NOUN
bam-7218	438	15	primary	primary	ADJ
bam-7218	438	16	myoblasts	myoblast	NOUN
bam-7218	438	17	as	as	ADV
bam-7218	438	18	well	well	ADV
bam-7218	438	19	as	as	ADP
bam-7218	438	20	of	of	ADP
bam-7218	438	21	normal	normal	ADJ
bam-7218	438	22	and	and	CCONJ
bam-7218	438	23	dystrophic	dystrophic	ADJ
bam-7218	438	24	human	human	ADJ
bam-7218	438	25	myoblasts	myoblast	NOUN
bam-7218	438	26	.	.	PUNCT
bam-7218	439	1	we	we	PRON
bam-7218	439	2	now	now	ADV
bam-7218	439	3	show	show	VERB
bam-7218	439	4	that	that	SCONJ
bam-7218	439	5	mmcm	mmcm	PROPN
bam-7218	439	6	exert	exert	VERB
bam-7218	439	7	different	different	ADJ
bam-7218	439	8	effects	effect	NOUN
bam-7218	439	9	on	on	ADP
bam-7218	439	10	murine	murine	ADJ
bam-7218	439	11	myogenic	myogenic	ADJ
bam-7218	439	12	cells	cell	NOUN
bam-7218	439	13	,	,	PUNCT
bam-7218	439	14	depending	depend	VERB
bam-7218	439	15	on	on	ADP
bam-7218	439	16	their	their	PRON
bam-7218	439	17	physiological	physiological	ADJ
bam-7218	439	18	state	state	NOUN
bam-7218	439	19	.	.	PUNCT
bam-7218	440	1	specifically	specifically	ADV
bam-7218	440	2	,	,	PUNCT
bam-7218	440	3	macrophagic	macrophagic	ADJ
bam-7218	440	4	factors	factor	NOUN
bam-7218	440	5	turned	turn	VERB
bam-7218	440	6	out	out	ADP
bam-7218	440	7	to	to	PART
bam-7218	440	8	have	have	VERB
bam-7218	440	9	an	an	DET
bam-7218	440	10	anti	anti	ADJ
bam-7218	440	11	-	-	ADJ
bam-7218	440	12	apoptotic	apoptotic	ADJ
bam-7218	440	13	action	action	NOUN
bam-7218	440	14	on	on	ADP
bam-7218	440	15	freshly	freshly	ADV
bam-7218	440	16	isolated	isolate	VERB
bam-7218	440	17	satellite	satellite	NOUN
bam-7218	440	18	cells	cell	NOUN
bam-7218	440	19	and	and	CCONJ
bam-7218	440	20	a	a	DET
bam-7218	440	21	pro	pro	ADJ
bam-7218	440	22	-	-	ADJ
bam-7218	440	23	proliferative	proliferative	ADJ
bam-7218	440	24	effect	effect	NOUN
bam-7218	440	25	on	on	ADP
bam-7218	440	26	established	establish	VERB
bam-7218	440	27	cultures	culture	NOUN
bam-7218	440	28	of	of	ADP
bam-7218	440	29	satellite	satellite	NOUN
bam-7218	440	30	-	-	PUNCT
bam-7218	440	31	derived	derive	VERB
bam-7218	440	32	myoblasts	myoblast	NOUN
bam-7218	440	33	.	.	PUNCT
bam-7218	441	1	when	when	SCONJ
bam-7218	441	2	used	use	VERB
bam-7218	441	3	to	to	PART
bam-7218	441	4	challenge	challenge	VERB
bam-7218	441	5	muscle	muscle	NOUN
bam-7218	441	6	-	-	PUNCT
bam-7218	441	7	derived	derive	VERB
bam-7218	441	8	murine	murine	ADJ
bam-7218	441	9	fibro	fibro	NOUN
bam-7218	441	10	-	-	PUNCT
bam-7218	441	11	adipogenic	adipogenic	ADJ
bam-7218	441	12	precursors	precursor	NOUN
bam-7218	441	13	,	,	PUNCT
bam-7218	441	14	mmcm	mmcm	NOUN
bam-7218	441	15	did	do	AUX
bam-7218	441	16	not	not	PART
bam-7218	441	17	appear	appear	VERB
bam-7218	441	18	to	to	PART
bam-7218	441	19	modify	modify	VERB
bam-7218	441	20	their	their	PRON
bam-7218	441	21	proliferation	proliferation	NOUN
bam-7218	441	22	rate	rate	NOUN
bam-7218	441	23	but	but	CCONJ
bam-7218	441	24	it	it	PRON
bam-7218	441	25	showed	show	VERB
bam-7218	441	26	a	a	DET
bam-7218	441	27	potent	potent	ADJ
bam-7218	441	28	anti	anti	ADJ
bam-7218	441	29	-	-	ADJ
bam-7218	441	30	adipogenic	adipogenic	ADJ
bam-7218	441	31	effect	effect	NOUN
bam-7218	441	32	,	,	PUNCT
bam-7218	441	33	which	which	PRON
bam-7218	441	34	did	do	AUX
bam-7218	441	35	not	not	PART
bam-7218	441	36	appear	appear	VERB
bam-7218	441	37	to	to	PART
bam-7218	441	38	involve	involve	VERB
bam-7218	441	39	the	the	DET
bam-7218	441	40	triggering	triggering	NOUN
bam-7218	441	41	of	of	ADP
bam-7218	441	42	apoptosis	apoptosis	NOUN
bam-7218	441	43	.	.	PUNCT
bam-7218	442	1	interestingly	interestingly	ADV
bam-7218	442	2	,	,	PUNCT
bam-7218	442	3	the	the	DET
bam-7218	442	4	effect	effect	NOUN
bam-7218	442	5	on	on	ADP
bam-7218	442	6	fap	fap	NOUN
bam-7218	442	7	differentiation	differentiation	NOUN
bam-7218	442	8	seems	seem	VERB
bam-7218	442	9	to	to	PART
bam-7218	442	10	be	be	AUX
bam-7218	442	11	at	at	ADP
bam-7218	442	12	least	least	ADJ
bam-7218	442	13	in	in	ADP
bam-7218	442	14	part	part	NOUN
bam-7218	442	15	related	relate	VERB
bam-7218	442	16	to	to	ADP
bam-7218	442	17	the	the	DET
bam-7218	442	18	exosomes	exosome	NOUN
bam-7218	442	19	found	find	VERB
bam-7218	442	20	in	in	ADP
bam-7218	442	21	mmcm	mmcm	PROPN
bam-7218	442	22	.	.	PUNCT
bam-7218	443	1	lastly	lastly	ADV
bam-7218	443	2	,	,	PUNCT
bam-7218	443	3	we	we	PRON
bam-7218	443	4	tested	test	VERB
bam-7218	443	5	the	the	DET
bam-7218	443	6	effects	effect	NOUN
bam-7218	443	7	of	of	ADP
bam-7218	443	8	mmcm	mmcm	NOUN
bam-7218	443	9	on	on	ADP
bam-7218	443	10	human	human	ADJ
bam-7218	443	11	,	,	PUNCT
bam-7218	443	12	muscle	muscle	NOUN
bam-7218	443	13	-	-	PUNCT
bam-7218	443	14	derived	derive	VERB
bam-7218	443	15	pericytes	pericyte	NOUN
bam-7218	443	16	,	,	PUNCT
bam-7218	443	17	a	a	DET
bam-7218	443	18	population	population	NOUN
bam-7218	443	19	of	of	ADP
bam-7218	443	20	multi	multi	ADJ
bam-7218	443	21	potent	potent	ADJ
bam-7218	443	22	precursor	precursor	NOUN
bam-7218	443	23	cells	cell	NOUN
bam-7218	443	24	known	know	VERB
bam-7218	443	25	to	to	PART
bam-7218	443	26	exhibit	exhibit	VERB
bam-7218	443	27	myogenic	myogenic	ADJ
bam-7218	443	28	potential	potential	NOUN
bam-7218	443	29	.	.	PUNCT
bam-7218	444	1	similarly	similarly	ADV
bam-7218	444	2	to	to	ADP
bam-7218	444	3	what	what	PRON
bam-7218	444	4	we	we	PRON
bam-7218	444	5	found	find	VERB
bam-7218	444	6	in	in	ADP
bam-7218	444	7	faps	fap	NOUN
bam-7218	444	8	,	,	PUNCT
bam-7218	444	9	mmcm	mmcm	NOUN
bam-7218	444	10	did	do	AUX
bam-7218	444	11	not	not	PART
bam-7218	444	12	affect	affect	VERB
bam-7218	444	13	the	the	DET
bam-7218	444	14	proliferation	proliferation	NOUN
bam-7218	444	15	rate	rate	NOUN
bam-7218	444	16	of	of	ADP
bam-7218	444	17	cultured	cultured	ADJ
bam-7218	444	18	pericytes	pericyte	NOUN
bam-7218	444	19	,	,	PUNCT
bam-7218	444	20	but	but	CCONJ
bam-7218	444	21	,	,	PUNCT
bam-7218	444	22	somewhat	somewhat	ADV
bam-7218	444	23	surprisingly	surprisingly	ADV
bam-7218	444	24	,	,	PUNCT
bam-7218	444	25	it	it	PRON
bam-7218	444	26	seemed	seem	VERB
bam-7218	444	27	to	to	PART
bam-7218	444	28	actually	actually	ADV
bam-7218	444	29	decrease	decrease	VERB
bam-7218	444	30	their	their	PRON
bam-7218	444	31	capability	capability	NOUN
bam-7218	444	32	to	to	PART
bam-7218	444	33	differentiate	differentiate	VERB
bam-7218	444	34	towards	towards	ADP
bam-7218	444	35	skeletal	skeletal	ADJ
bam-7218	444	36	muscle	muscle	NOUN
bam-7218	444	37	cells	cell	NOUN
bam-7218	444	38	and	and	CCONJ
bam-7218	444	39	form	form	NOUN
bam-7218	444	40	myotubes	myotube	NOUN
bam-7218	444	41	.	.	PUNCT
bam-7218	445	1	3.8	3.8	NUM
bam-7218	445	2	loss	loss	NOUN
bam-7218	445	3	of	of	ADP
bam-7218	445	4	mmp13	mmp13	PROPN
bam-7218	445	5	impedes	impede	VERB
bam-7218	445	6	satellite	satellite	NOUN
bam-7218	445	7	cell	cell	NOUN
bam-7218	445	8	migration	migration	NOUN
bam-7218	445	9	and	and	CCONJ
bam-7218	445	10	delays	delay	NOUN
bam-7218	445	11	muscle	muscle	NOUN
bam-7218	445	12	regeneration	regeneration	NOUN
bam-7218	445	13	lucas	lucas	PROPN
bam-7218	445	14	smith	smith	PROPN
bam-7218	445	15	(	(	PUNCT
bam-7218	445	16	a	a	PROPN
bam-7218	445	17	)	)	PUNCT
bam-7218	445	18	,	,	PUNCT
bam-7218	445	19	hui	hui	PROPN
bam-7218	445	20	jean	jean	PROPN
bam-7218	445	21	kok	kok	PROPN
bam-7218	445	22	(	(	PUNCT
bam-7218	445	23	b	b	NOUN
bam-7218	445	24	)	)	PUNCT
bam-7218	445	25	,	,	PUNCT
bam-7218	445	26	elisabeth	elisabeth	PROPN
bam-7218	445	27	barton	barton	PROPN
bam-7218	445	28	(	(	PUNCT
bam-7218	445	29	b	b	NOUN
bam-7218	445	30	)	)	PUNCT
bam-7218	445	31	(	(	PUNCT
bam-7218	445	32	a	a	X
bam-7218	445	33	)	)	PUNCT
bam-7218	445	34	applied	apply	VERB
bam-7218	445	35	physiology	physiology	NOUN
bam-7218	445	36	&	&	CCONJ
bam-7218	445	37	kinesiology	kinesiology	PROPN
bam-7218	445	38	,	,	PUNCT
bam-7218	445	39	university	university	PROPN
bam-7218	445	40	of	of	ADP
bam-7218	445	41	florida	florida	PROPN
bam-7218	445	42	.	.	PUNCT
bam-7218	446	1	usa	usa	PROPN
bam-7218	446	2	;	;	PUNCT
bam-7218	446	3	(	(	PUNCT
bam-7218	446	4	b	b	X
bam-7218	446	5	)	)	PUNCT
bam-7218	446	6	bioengineering	bioengineering	NOUN
bam-7218	446	7	,	,	PUNCT
bam-7218	446	8	university	university	PROPN
bam-7218	446	9	of	of	ADP
bam-7218	446	10	pennsylvania	pennsylvania	PROPN
bam-7218	446	11	,	,	PUNCT
bam-7218	446	12	usa	usa	PROPN
bam-7218	446	13	.	.	PROPN
bam-7218	447	1	e	e	X
bam-7218	447	2	-	-	NOUN
bam-7218	447	3	mail	mail	NOUN
bam-7218	447	4	:	:	PUNCT
bam-7218	447	5	erbarton@ufl.edu	erbarton@ufl.edu	VERB
bam-7218	447	6	skeletal	skeletal	ADJ
bam-7218	447	7	muscle	muscle	NOUN
bam-7218	447	8	regeneration	regeneration	NOUN
bam-7218	447	9	requires	require	VERB
bam-7218	447	10	coordinated	coordinate	VERB
bam-7218	447	11	remodeling	remodeling	NOUN
bam-7218	447	12	of	of	ADP
bam-7218	447	13	the	the	DET
bam-7218	447	14	extracellular	extracellular	ADJ
bam-7218	447	15	matrix	matrix	NOUN
bam-7218	447	16	(	(	PUNCT
bam-7218	447	17	ecm	ecm	PROPN
bam-7218	447	18	)	)	PUNCT
bam-7218	447	19	,	,	PUNCT
bam-7218	447	20	and	and	CCONJ
bam-7218	447	21	matrix	matrix	NOUN
bam-7218	447	22	metalloproteinases	metalloproteinase	NOUN
bam-7218	447	23	(	(	PUNCT
bam-7218	447	24	mmp)s	mmp)s	PROPN
bam-7218	447	25	play	play	VERB
bam-7218	447	26	a	a	DET
bam-7218	447	27	critical	critical	ADJ
bam-7218	447	28	role	role	NOUN
bam-7218	447	29	.	.	PUNCT
bam-7218	448	1	mmp-13	mmp-13	NOUN
bam-7218	448	2	,	,	PUNCT
bam-7218	448	3	a	a	DET
bam-7218	448	4	collagenase	collagenase	NOUN
bam-7218	448	5	,	,	PUNCT
bam-7218	448	6	was	be	AUX
bam-7218	448	7	shown	show	VERB
bam-7218	448	8	to	to	PART
bam-7218	448	9	have	have	VERB
bam-7218	448	10	high	high	ADJ
bam-7218	448	11	expression	expression	NOUN
bam-7218	448	12	during	during	ADP
bam-7218	448	13	regeneration	regeneration	NOUN
bam-7218	448	14	and	and	CCONJ
bam-7218	448	15	regulate	regulate	VERB
bam-7218	448	16	c2c12	c2c12	PROPN
bam-7218	448	17	myoblast	myoblast	ADJ
bam-7218	448	18	migration	migration	NOUN
bam-7218	448	19	,	,	PUNCT
bam-7218	448	20	yet	yet	ADV
bam-7218	448	21	mmp-13	mmp-13	NOUN
bam-7218	448	22	’s	’s	PART
bam-7218	448	23	function	function	NOUN
bam-7218	448	24	in	in	ADP
bam-7218	448	25	skeletal	skeletal	ADJ
bam-7218	448	26	muscle	muscle	NOUN
bam-7218	448	27	in	in	ADP
bam-7218	448	28	vivo	vivo	NOUN
bam-7218	448	29	has	have	AUX
bam-7218	448	30	not	not	PART
bam-7218	448	31	been	be	AUX
bam-7218	448	32	studied	study	VERB
bam-7218	448	33	.	.	PUNCT
bam-7218	449	1	under	under	ADP
bam-7218	449	2	baseline	baseline	NOUN
bam-7218	449	3	conditions	condition	NOUN
bam-7218	449	4	the	the	DET
bam-7218	449	5	mmp13-/mouse	mmp13-/mouse	NOUN
bam-7218	449	6	does	do	AUX
bam-7218	449	7	not	not	PART
bam-7218	449	8	exhibit	exhibit	VERB
bam-7218	449	9	a	a	DET
bam-7218	449	10	muscle	muscle	NOUN
bam-7218	449	11	phenotype	phenotype	NOUN
bam-7218	449	12	;	;	PUNCT
bam-7218	449	13	including	include	VERB
bam-7218	449	14	muscle	muscle	NOUN
bam-7218	449	15	mechanics	mechanic	NOUN
bam-7218	449	16	,	,	PUNCT
bam-7218	449	17	fiber	fiber	NOUN
bam-7218	449	18	size	size	NOUN
bam-7218	449	19	,	,	PUNCT
bam-7218	449	20	capillary	capillary	ADJ
bam-7218	449	21	density	density	NOUN
bam-7218	449	22	,	,	PUNCT
bam-7218	449	23	or	or	CCONJ
bam-7218	449	24	ecm	ecm	PROPN
bam-7218	449	25	area	area	NOUN
bam-7218	449	26	.	.	PUNCT
bam-7218	450	1	however	however	ADV
bam-7218	450	2	,	,	PUNCT
bam-7218	450	3	in	in	ADP
bam-7218	450	4	muscle	muscle	NOUN
bam-7218	450	5	injured	injure	VERB
bam-7218	450	6	with	with	ADP
bam-7218	450	7	cardiotoxin	cardiotoxin	NOUN
bam-7218	450	8	,	,	PUNCT
bam-7218	450	9	regeneration	regeneration	NOUN
bam-7218	450	10	is	be	AUX
bam-7218	450	11	delayed	delay	VERB
bam-7218	450	12	at	at	ADP
bam-7218	450	13	2	2	NUM
bam-7218	450	14	weeks	week	NOUN
bam-7218	450	15	post	post	NOUN
bam-7218	450	16	injury	injury	NOUN
bam-7218	450	17	.	.	PUNCT
bam-7218	451	1	to	to	PART
bam-7218	451	2	determine	determine	VERB
bam-7218	451	3	if	if	SCONJ
bam-7218	451	4	these	these	DET
bam-7218	451	5	effects	effect	NOUN
bam-7218	451	6	were	be	AUX
bam-7218	451	7	mediated	mediate	VERB
bam-7218	451	8	by	by	ADP
bam-7218	451	9	satellite	satellite	NOUN
bam-7218	451	10	cell	cell	NOUN
bam-7218	451	11	deficiencies	deficiency	NOUN
bam-7218	451	12	when	when	SCONJ
bam-7218	451	13	lacking	lack	VERB
bam-7218	451	14	mmp-13	mmp-13	NOUN
bam-7218	451	15	,	,	PUNCT
bam-7218	451	16	live	live	ADJ
bam-7218	451	17	cell	cell	NOUN
bam-7218	451	18	imaging	imaging	NOUN
bam-7218	451	19	of	of	ADP
bam-7218	451	20	single	single	ADJ
bam-7218	451	21	fiber	fiber	NOUN
bam-7218	451	22	cultures	culture	NOUN
bam-7218	451	23	were	be	AUX
bam-7218	451	24	conducted	conduct	VERB
bam-7218	451	25	to	to	PART
bam-7218	451	26	directly	directly	ADV
bam-7218	451	27	measure	measure	VERB
bam-7218	451	28	migration	migration	NOUN
bam-7218	451	29	velocity	velocity	NOUN
bam-7218	451	30	.	.	PUNCT
bam-7218	452	1	mmp13-/satellite	mmp13-/satellite	NOUN
bam-7218	452	2	cells	cell	NOUN
bam-7218	452	3	had	have	VERB
bam-7218	452	4	33	33	NUM
bam-7218	452	5	%	%	NOUN
bam-7218	452	6	lower	low	ADJ
bam-7218	452	7	migration	migration	NOUN
bam-7218	452	8	velocity	velocity	NOUN
bam-7218	452	9	than	than	ADP
bam-7218	452	10	controls	control	NOUN
bam-7218	452	11	.	.	PUNCT
bam-7218	453	1	in	in	ADP
bam-7218	453	2	addition	addition	NOUN
bam-7218	453	3	,	,	PUNCT
bam-7218	453	4	3d	3d	NUM
bam-7218	453	5	invasion	invasion	NOUN
bam-7218	453	6	assays	assay	VERB
bam-7218	453	7	through	through	ADP
bam-7218	453	8	basement	basement	NOUN
bam-7218	453	9	membrane	membrane	NOUN
bam-7218	453	10	extract	extract	NOUN
bam-7218	453	11	(	(	PUNCT
bam-7218	453	12	bme	bme	NOUN
bam-7218	453	13	)	)	PUNCT
bam-7218	453	14	revealed	reveal	VERB
bam-7218	453	15	that	that	SCONJ
bam-7218	453	16	mmp13-/cells	mmp13-/cell	NOUN
bam-7218	453	17	had	have	VERB
bam-7218	453	18	a	a	DET
bam-7218	453	19	53	53	NUM
bam-7218	453	20	%	%	NOUN
bam-7218	453	21	reduced	reduce	VERB
bam-7218	453	22	ability	ability	NOUN
bam-7218	453	23	to	to	PART
bam-7218	453	24	migrate	migrate	VERB
bam-7218	453	25	through	through	ADP
bam-7218	453	26	bme	bme	NOUN
bam-7218	453	27	substrate	substrate	NOUN
bam-7218	453	28	..	..	PUNCT
bam-7218	453	29	these	these	DET
bam-7218	453	30	data	datum	NOUN
bam-7218	453	31	extend	extend	VERB
bam-7218	453	32	evidence	evidence	NOUN
bam-7218	453	33	of	of	ADP
bam-7218	453	34	mmp-13	mmp-13	PUNCT
bam-7218	453	35	being	be	AUX
bam-7218	453	36	a	a	DET
bam-7218	453	37	critical	critical	ADJ
bam-7218	453	38	component	component	NOUN
bam-7218	453	39	of	of	ADP
bam-7218	453	40	myoblast	myoblast	ADJ
bam-7218	453	41	migration	migration	NOUN
bam-7218	453	42	in	in	ADP
bam-7218	453	43	primary	primary	ADJ
bam-7218	453	44	cells	cell	NOUN
bam-7218	453	45	in	in	ADP
bam-7218	453	46	2d	2d	NUM
bam-7218	453	47	and	and	CCONJ
bam-7218	453	48	3d	3d	NOUN
bam-7218	453	49	.	.	PUNCT
bam-7218	454	1	to	to	PART
bam-7218	454	2	further	far	ADV
bam-7218	454	3	investigate	investigate	VERB
bam-7218	454	4	the	the	DET
bam-7218	454	5	contribution	contribution	NOUN
bam-7218	454	6	that	that	PRON
bam-7218	454	7	mmp-13	mmp-13	VERB
bam-7218	454	8	mediated	mediate	VERB
bam-7218	454	9	migration	migration	NOUN
bam-7218	454	10	had	have	VERB
bam-7218	454	11	on	on	ADP
bam-7218	454	12	the	the	DET
bam-7218	454	13	repair	repair	NOUN
bam-7218	454	14	process	process	NOUN
bam-7218	454	15	,	,	PUNCT
bam-7218	454	16	we	we	PRON
bam-7218	454	17	generated	generate	VERB
bam-7218	454	18	a	a	DET
bam-7218	454	19	mouse	mouse	NOUN
bam-7218	454	20	with	with	ADP
bam-7218	454	21	inducible	inducible	ADJ
bam-7218	454	22	and	and	CCONJ
bam-7218	454	23	satellite	satellite	NOUN
bam-7218	454	24	cell	cell	NOUN
bam-7218	454	25	specific	specific	ADJ
bam-7218	454	26	deletion	deletion	NOUN
bam-7218	454	27	of	of	ADP
bam-7218	454	28	mmp13	mmp13	NOUN
bam-7218	454	29	.	.	PUNCT
bam-7218	455	1	these	these	DET
bam-7218	455	2	mice	mouse	NOUN
bam-7218	455	3	mirrored	mirror	VERB
bam-7218	455	4	many	many	ADJ
bam-7218	455	5	of	of	ADP
bam-7218	455	6	the	the	DET
bam-7218	455	7	phenotypes	phenotype	NOUN
bam-7218	455	8	of	of	ADP
bam-7218	455	9	the	the	DET
bam-7218	455	10	global	global	ADJ
bam-7218	455	11	knockout	knockout	NOUN
bam-7218	455	12	,	,	PUNCT
bam-7218	455	13	including	include	VERB
bam-7218	455	14	a	a	DET
bam-7218	455	15	reduction	reduction	NOUN
bam-7218	455	16	in	in	ADP
bam-7218	455	17	satellite	satellite	NOUN
bam-7218	455	18	cell	cell	NOUN
bam-7218	455	19	migration	migration	NOUN
bam-7218	455	20	,	,	PUNCT
bam-7218	455	21	and	and	CCONJ
bam-7218	455	22	delayed	delay	VERB
bam-7218	455	23	resolution	resolution	NOUN
bam-7218	455	24	of	of	ADP
bam-7218	455	25	damage	damage	NOUN
bam-7218	455	26	by	by	ADP
bam-7218	455	27	cardiotoxin	cardiotoxin	NOUN
bam-7218	455	28	injection	injection	NOUN
bam-7218	455	29	.	.	PUNCT
bam-7218	456	1	in	in	ADP
bam-7218	456	2	sum	sum	NOUN
bam-7218	456	3	,	,	PUNCT
bam-7218	456	4	mmp-13	mmp-13	X
bam-7218	456	5	mediated	mediate	VERB
bam-7218	456	6	satellite	satellite	NOUN
bam-7218	456	7	cell	cell	NOUN
bam-7218	456	8	migration	migration	NOUN
bam-7218	456	9	is	be	AUX
bam-7218	456	10	an	an	DET
bam-7218	456	11	important	important	ADJ
bam-7218	456	12	factor	factor	NOUN
bam-7218	456	13	for	for	ADP
bam-7218	456	14	efficient	efficient	ADJ
bam-7218	456	15	muscle	muscle	NOUN
bam-7218	456	16	regeneration	regeneration	NOUN
bam-7218	456	17	.	.	PUNCT
bam-7218	457	1	supported	support	VERB
bam-7218	457	2	by	by	ADP
bam-7218	457	3	nih	nih	PROPN
bam-7218	457	4	r01	r01	PROPN
bam-7218	457	5	ar057363	ar057363	PROPN
bam-7218	457	6	.	.	PUNCT
bam-7218	458	1	october	october	PROPN
bam-7218	458	2	13	13	NUM
bam-7218	458	3	th	th	NOUN
bam-7218	458	4	session	session	NOUN
bam-7218	458	5	4	4	NUM
bam-7218	458	6	genetic	genetic	ADJ
bam-7218	458	7	and	and	CCONJ
bam-7218	458	8	epigenetic	epigenetic	ADJ
bam-7218	458	9	alterations	alteration	NOUN
bam-7218	458	10	in	in	ADP
bam-7218	458	11	muscle	muscle	NOUN
bam-7218	458	12	dystrophies	dystrophy	NOUN
bam-7218	458	13	and	and	CCONJ
bam-7218	458	14	myopathies	myopathy	NOUN
bam-7218	458	15	4.1	4.1	NUM
bam-7218	458	16	histone	histone	NOUN
bam-7218	458	17	h3	h3	NOUN
bam-7218	458	18	lysine	lysine	NOUN
bam-7218	458	19	9	9	NUM
bam-7218	458	20	methyltransferases	methyltransferase	NOUN
bam-7218	458	21	g9a	g9a	ADV
bam-7218	458	22	and	and	CCONJ
bam-7218	458	23	glp	glp	NOUN
bam-7218	458	24	as	as	ADP
bam-7218	458	25	potential	potential	ADJ
bam-7218	458	26	pharmacological	pharmacological	ADJ
bam-7218	458	27	targets	target	NOUN
bam-7218	458	28	in	in	ADP
bam-7218	458	29	skeletal	skeletal	ADJ
bam-7218	458	30	muscle	muscle	NOUN
bam-7218	458	31	regeneration	regeneration	NOUN
bam-7218	458	32	and	and	CCONJ
bam-7218	458	33	duchenne	duchenne	VERB
bam-7218	458	34	muscular	muscular	ADJ
bam-7218	458	35	dystrophy	dystrophy	NOUN
bam-7218	458	36	mailto:libero.vitiello@unipd.it	mailto:libero.vitiello@unipd.it	PROPN
bam-7218	458	37	mailto:erbarton@ufl.edu	mailto:erbarton@ufl.edu	PROPN
bam-7218	458	38	14	14	NUM
bam-7218	458	39	th	th	NUM
bam-7218	458	40	iiim	iiim	NOUN
bam-7218	458	41	meeting	meeting	NOUN
bam-7218	458	42	,	,	PUNCT
bam-7218	458	43	assisi	assisi	PROPN
bam-7218	458	44	,	,	PUNCT
bam-7218	458	45	italy	italy	PROPN
bam-7218	458	46	october	october	PROPN
bam-7218	458	47	12	12	NUM
bam-7218	458	48	-	-	SYM
bam-7218	458	49	15	15	NUM
bam-7218	458	50	2017	2017	NUM
bam-7218	458	51	eur	eur	PROPN
bam-7218	458	52	j	j	PROPN
bam-7218	458	53	transl	transl	PROPN
bam-7218	458	54	myol	myol	ADV
bam-7218	458	55	27	27	NUM
bam-7218	458	56	(	(	PUNCT
bam-7218	458	57	4	4	NUM
bam-7218	458	58	):	):	SYM
bam-7218	458	59	185	185	NUM
bam-7218	458	60	-	-	SYM
bam-7218	458	61	224	224	NUM
bam-7218	458	62	198	198	NUM
bam-7218	458	63	valeria	valeria	PROPN
bam-7218	458	64	bianconi	bianconi	NOUN
bam-7218	458	65	,	,	PUNCT
bam-7218	458	66	beatrice	beatrice	PROPN
bam-7218	458	67	biferali	biferali	PROPN
bam-7218	458	68	,	,	PUNCT
bam-7218	458	69	chiara	chiara	PROPN
bam-7218	458	70	mozzetta	mozzetta	PROPN
bam-7218	458	71	dept	dept	NOUN
bam-7218	458	72	of	of	ADP
bam-7218	458	73	biology	biology	NOUN
bam-7218	458	74	and	and	CCONJ
bam-7218	458	75	biotechnology	biotechnology	NOUN
bam-7218	458	76	“	"	PUNCT
bam-7218	458	77	charles	charles	PROPN
bam-7218	458	78	darwin	darwin	PROPN
bam-7218	458	79	”	"	PUNCT
bam-7218	458	80	,	,	PUNCT
bam-7218	458	81	sapienza	sapienza	PROPN
bam-7218	458	82	university	university	PROPN
bam-7218	458	83	of	of	ADP
bam-7218	458	84	rome	rome	PROPN
bam-7218	458	85	,	,	PUNCT
bam-7218	458	86	italy	italy	PROPN
bam-7218	458	87	.	.	PUNCT
bam-7218	459	1	e	e	X
bam-7218	459	2	-	-	NOUN
bam-7218	459	3	mail	mail	NOUN
bam-7218	459	4	:	:	PUNCT
bam-7218	459	5	valeria.bianconi@uniroma1.it	valeria.bianconi@uniroma1.it	PROPN
bam-7218	459	6	histone	histone	NOUN
bam-7218	459	7	lysine	lysine	NOUN
bam-7218	459	8	methyltransferases	methyltransferase	NOUN
bam-7218	459	9	(	(	PUNCT
bam-7218	459	10	kmts	kmts	PROPN
bam-7218	459	11	)	)	PUNCT
bam-7218	459	12	are	be	AUX
bam-7218	459	13	epigenetic	epigenetic	ADJ
bam-7218	459	14	modifiers	modifier	NOUN
bam-7218	459	15	that	that	PRON
bam-7218	459	16	dynamically	dynamically	ADV
bam-7218	459	17	control	control	VERB
bam-7218	459	18	gene	gene	NOUN
bam-7218	459	19	expression	expression	NOUN
bam-7218	459	20	during	during	ADP
bam-7218	459	21	stem	stem	NOUN
bam-7218	459	22	cell	cell	NOUN
bam-7218	459	23	differentiation	differentiation	NOUN
bam-7218	459	24	.	.	PUNCT
bam-7218	460	1	among	among	ADP
bam-7218	460	2	the	the	DET
bam-7218	460	3	different	different	ADJ
bam-7218	460	4	kmts	kmts	NOUN
bam-7218	460	5	,	,	PUNCT
bam-7218	460	6	ehmt2	ehmt2	ADJ
bam-7218	460	7	/	/	SYM
bam-7218	460	8	g9a	g9a	ADV
bam-7218	460	9	and	and	CCONJ
bam-7218	460	10	ehmt1	ehmt1	PROPN
bam-7218	460	11	/	/	SYM
bam-7218	460	12	glp	glp	PROPN
bam-7218	460	13	,	,	PUNCT
bam-7218	460	14	responsible	responsible	ADJ
bam-7218	460	15	of	of	ADP
bam-7218	460	16	monoand	monoand	NOUN
bam-7218	460	17	di	di	NOUN
bam-7218	460	18	-	-	NOUN
bam-7218	460	19	methylation	methylation	NOUN
bam-7218	460	20	of	of	ADP
bam-7218	460	21	lysine	lysine	NOUN
bam-7218	460	22	9	9	NUM
bam-7218	460	23	of	of	ADP
bam-7218	460	24	histone	histone	NOUN
bam-7218	460	25	h3	h3	NOUN
bam-7218	460	26	(	(	PUNCT
bam-7218	460	27	h3k9	h3k9	NOUN
bam-7218	460	28	)	)	PUNCT
bam-7218	460	29	,	,	PUNCT
bam-7218	460	30	are	be	AUX
bam-7218	460	31	of	of	ADP
bam-7218	460	32	particular	particular	ADJ
bam-7218	460	33	relevance	relevance	NOUN
bam-7218	460	34	in	in	ADP
bam-7218	460	35	the	the	DET
bam-7218	460	36	context	context	NOUN
bam-7218	460	37	of	of	ADP
bam-7218	460	38	myogenesis	myogenesis	NOUN
bam-7218	460	39	since	since	SCONJ
bam-7218	460	40	they	they	PRON
bam-7218	460	41	have	have	AUX
bam-7218	460	42	been	be	AUX
bam-7218	460	43	shown	show	VERB
bam-7218	460	44	to	to	PART
bam-7218	460	45	control	control	VERB
bam-7218	460	46	the	the	DET
bam-7218	460	47	repression	repression	NOUN
bam-7218	460	48	of	of	ADP
bam-7218	460	49	muscle	muscle	NOUN
bam-7218	460	50	-	-	PUNCT
bam-7218	460	51	specific	specific	ADJ
bam-7218	460	52	genes	gene	NOUN
bam-7218	460	53	in	in	ADP
bam-7218	460	54	myogenic	myogenic	ADJ
bam-7218	460	55	precursors	precursor	NOUN
bam-7218	460	56	and	and	CCONJ
bam-7218	460	57	to	to	PART
bam-7218	460	58	prevent	prevent	VERB
bam-7218	460	59	their	their	PRON
bam-7218	460	60	premature	premature	ADJ
bam-7218	460	61	differentiation	differentiation	NOUN
bam-7218	460	62	.	.	PUNCT
bam-7218	461	1	modulation	modulation	NOUN
bam-7218	461	2	of	of	ADP
bam-7218	461	3	their	their	PRON
bam-7218	461	4	activity	activity	NOUN
bam-7218	461	5	might	might	AUX
bam-7218	461	6	therefore	therefore	ADV
bam-7218	461	7	be	be	AUX
bam-7218	461	8	exploited	exploit	VERB
bam-7218	461	9	to	to	PART
bam-7218	461	10	promote	promote	VERB
bam-7218	461	11	the	the	DET
bam-7218	461	12	expression	expression	NOUN
bam-7218	461	13	of	of	ADP
bam-7218	461	14	muscle	muscle	NOUN
bam-7218	461	15	-	-	PUNCT
bam-7218	461	16	specific	specific	ADJ
bam-7218	461	17	genes	gene	NOUN
bam-7218	461	18	and	and	CCONJ
bam-7218	461	19	to	to	PART
bam-7218	461	20	enhance	enhance	VERB
bam-7218	461	21	muscle	muscle	NOUN
bam-7218	461	22	differentiation	differentiation	NOUN
bam-7218	461	23	in	in	ADP
bam-7218	461	24	tissues	tissue	NOUN
bam-7218	461	25	whose	whose	DET
bam-7218	461	26	myogenic	myogenic	ADJ
bam-7218	461	27	capacity	capacity	NOUN
bam-7218	461	28	is	be	AUX
bam-7218	461	29	compromised	compromise	VERB
bam-7218	461	30	due	due	ADP
bam-7218	461	31	to	to	ADP
bam-7218	461	32	a	a	DET
bam-7218	461	33	pathological	pathological	ADJ
bam-7218	461	34	condition	condition	NOUN
bam-7218	461	35	,	,	PUNCT
bam-7218	461	36	as	as	ADP
bam-7218	461	37	in	in	ADP
bam-7218	461	38	the	the	DET
bam-7218	461	39	case	case	NOUN
bam-7218	461	40	of	of	ADP
bam-7218	461	41	muscles	muscle	NOUN
bam-7218	461	42	affected	affect	VERB
bam-7218	461	43	by	by	ADP
bam-7218	461	44	duchenne	duchenne	NOUN
bam-7218	461	45	muscular	muscular	ADJ
bam-7218	461	46	dystrophy	dystrophy	NOUN
bam-7218	461	47	(	(	PUNCT
bam-7218	461	48	dmd	dmd	NOUN
bam-7218	461	49	)	)	PUNCT
bam-7218	461	50	.	.	PUNCT
bam-7218	462	1	dmd	dmd	PROPN
bam-7218	462	2	is	be	AUX
bam-7218	462	3	a	a	DET
bam-7218	462	4	severe	severe	ADJ
bam-7218	462	5	x	x	ADJ
bam-7218	462	6	-	-	ADJ
bam-7218	462	7	linked	link	VERB
bam-7218	462	8	neuromuscular	neuromuscular	ADJ
bam-7218	462	9	degenerative	degenerative	ADJ
bam-7218	462	10	disorder	disorder	NOUN
bam-7218	462	11	that	that	PRON
bam-7218	462	12	leads	lead	VERB
bam-7218	462	13	to	to	ADP
bam-7218	462	14	progressive	progressive	ADJ
bam-7218	462	15	muscle	muscle	NOUN
bam-7218	462	16	weakness	weakness	NOUN
bam-7218	462	17	associated	associate	VERB
bam-7218	462	18	with	with	ADP
bam-7218	462	19	loss	loss	NOUN
bam-7218	462	20	of	of	ADP
bam-7218	462	21	muscle	muscle	NOUN
bam-7218	462	22	tissue	tissue	NOUN
bam-7218	462	23	and	and	CCONJ
bam-7218	462	24	replacement	replacement	NOUN
bam-7218	462	25	with	with	ADP
bam-7218	462	26	adipose	adipose	ADP
bam-7218	462	27	and	and	CCONJ
bam-7218	462	28	connective	connective	ADJ
bam-7218	462	29	infiltrates	infiltrate	NOUN
bam-7218	462	30	,	,	PUNCT
bam-7218	462	31	in	in	ADP
bam-7218	462	32	coincidence	coincidence	NOUN
bam-7218	462	33	with	with	ADP
bam-7218	462	34	the	the	DET
bam-7218	462	35	final	final	ADJ
bam-7218	462	36	stages	stage	NOUN
bam-7218	462	37	of	of	ADP
bam-7218	462	38	disease	disease	NOUN
bam-7218	462	39	.	.	PUNCT
bam-7218	463	1	despite	despite	SCONJ
bam-7218	463	2	recent	recent	ADJ
bam-7218	463	3	progresses	progress	NOUN
bam-7218	463	4	in	in	ADP
bam-7218	463	5	genome	genome	NOUN
bam-7218	463	6	editing	editing	NOUN
bam-7218	463	7	approaches	approach	NOUN
bam-7218	463	8	,	,	PUNCT
bam-7218	463	9	the	the	DET
bam-7218	463	10	cure	cure	NOUN
bam-7218	463	11	for	for	ADP
bam-7218	463	12	dmd	dmd	NOUN
bam-7218	463	13	is	be	AUX
bam-7218	463	14	still	still	ADV
bam-7218	463	15	a	a	DET
bam-7218	463	16	big	big	ADJ
bam-7218	463	17	challenge	challenge	NOUN
bam-7218	463	18	and	and	CCONJ
bam-7218	463	19	pharmacological	pharmacological	ADJ
bam-7218	463	20	therapies	therapy	NOUN
bam-7218	463	21	aimed	aim	VERB
bam-7218	463	22	to	to	PART
bam-7218	463	23	counteract	counteract	VERB
bam-7218	463	24	the	the	DET
bam-7218	463	25	fibro	fibro	NOUN
bam-7218	463	26	-	-	PUNCT
bam-7218	463	27	adipogenic	adipogenic	ADJ
bam-7218	463	28	degeneration	degeneration	NOUN
bam-7218	463	29	and	and	CCONJ
bam-7218	463	30	to	to	PART
bam-7218	463	31	promote	promote	VERB
bam-7218	463	32	the	the	DET
bam-7218	463	33	compensatory	compensatory	ADJ
bam-7218	463	34	regeneration	regeneration	NOUN
bam-7218	463	35	,	,	PUNCT
bam-7218	463	36	typical	typical	ADJ
bam-7218	463	37	of	of	ADP
bam-7218	463	38	the	the	DET
bam-7218	463	39	early	early	ADJ
bam-7218	463	40	stages	stage	NOUN
bam-7218	463	41	of	of	ADP
bam-7218	463	42	disease	disease	NOUN
bam-7218	463	43	,	,	PUNCT
bam-7218	463	44	hold	hold	VERB
bam-7218	463	45	great	great	ADJ
bam-7218	463	46	promise	promise	NOUN
bam-7218	463	47	to	to	PART
bam-7218	463	48	slow	slow	VERB
bam-7218	463	49	-	-	PUNCT
bam-7218	463	50	down	down	ADP
bam-7218	463	51	dmd	dmd	NOUN
bam-7218	463	52	progression	progression	NOUN
bam-7218	463	53	.	.	PUNCT
bam-7218	464	1	here	here	ADV
bam-7218	464	2	we	we	PRON
bam-7218	464	3	provide	provide	VERB
bam-7218	464	4	evidence	evidence	NOUN
bam-7218	464	5	of	of	ADP
bam-7218	464	6	the	the	DET
bam-7218	464	7	pro	pro	ADJ
bam-7218	464	8	-	-	ADJ
bam-7218	464	9	regenerative	regenerative	ADJ
bam-7218	464	10	effect	effect	NOUN
bam-7218	464	11	of	of	ADP
bam-7218	464	12	g9a	g9a	NOUN
bam-7218	464	13	/	/	SYM
bam-7218	464	14	glp	glp	NOUN
bam-7218	464	15	specific	specific	ADJ
bam-7218	464	16	inhibitors	inhibitor	NOUN
bam-7218	464	17	in	in	ADP
bam-7218	464	18	vivo	vivo	NOUN
bam-7218	464	19	.	.	PUNCT
bam-7218	465	1	our	our	PRON
bam-7218	465	2	results	result	NOUN
bam-7218	465	3	show	show	VERB
bam-7218	465	4	that	that	SCONJ
bam-7218	465	5	in	in	ADP
bam-7218	465	6	vivo	vivo	ADJ
bam-7218	465	7	inhibition	inhibition	NOUN
bam-7218	465	8	of	of	ADP
bam-7218	465	9	g9a	g9a	NOUN
bam-7218	465	10	/	/	SYM
bam-7218	465	11	glp	glp	NOUN
bam-7218	465	12	-	-	PUNCT
bam-7218	465	13	mediated	mediate	VERB
bam-7218	465	14	h3k9me2	h3k9me2	PUNCT
bam-7218	465	15	improves	improve	VERB
bam-7218	465	16	skeletal	skeletal	ADJ
bam-7218	465	17	muscle	muscle	NOUN
bam-7218	465	18	regeneration	regeneration	NOUN
bam-7218	465	19	.	.	PUNCT
bam-7218	466	1	this	this	PRON
bam-7218	466	2	is	be	AUX
bam-7218	466	3	caused	cause	VERB
bam-7218	466	4	by	by	ADP
bam-7218	466	5	an	an	DET
bam-7218	466	6	accelerated	accelerate	VERB
bam-7218	466	7	myogenic	myogenic	ADJ
bam-7218	466	8	capacity	capacity	NOUN
bam-7218	466	9	of	of	ADP
bam-7218	466	10	muscle	muscle	NOUN
bam-7218	466	11	stem	stem	NOUN
bam-7218	466	12	cells	cell	NOUN
bam-7218	466	13	(	(	PUNCT
bam-7218	466	14	muscs	musc	NOUN
bam-7218	466	15	)	)	PUNCT
bam-7218	466	16	and	and	CCONJ
bam-7218	466	17	by	by	ADP
bam-7218	466	18	an	an	DET
bam-7218	466	19	impaired	impaired	ADJ
bam-7218	466	20	adipogenic	adipogenic	ADJ
bam-7218	466	21	differentiation	differentiation	NOUN
bam-7218	466	22	of	of	ADP
bam-7218	466	23	fibro	fibro	PROPN
bam-7218	466	24	-	-	PUNCT
bam-7218	466	25	adipogenic	adipogenic	ADJ
bam-7218	466	26	progenitors	progenitor	NOUN
bam-7218	466	27	(	(	PUNCT
bam-7218	466	28	faps	fap	NOUN
bam-7218	466	29	)	)	PUNCT
bam-7218	466	30	,	,	PUNCT
bam-7218	466	31	which	which	PRON
bam-7218	466	32	rather	rather	ADV
bam-7218	466	33	unmasks	unmask	VERB
bam-7218	466	34	a	a	DET
bam-7218	466	35	previously	previously	ADV
bam-7218	466	36	silent	silent	ADJ
bam-7218	466	37	myogenic	myogenic	ADJ
bam-7218	466	38	capacity	capacity	NOUN
bam-7218	466	39	.	.	PUNCT
bam-7218	467	1	our	our	PRON
bam-7218	467	2	preliminary	preliminary	ADJ
bam-7218	467	3	results	result	NOUN
bam-7218	467	4	provide	provide	VERB
bam-7218	467	5	proof	proof	NOUN
bam-7218	467	6	of	of	ADP
bam-7218	467	7	concept	concept	NOUN
bam-7218	467	8	of	of	ADP
bam-7218	467	9	the	the	DET
bam-7218	467	10	use	use	NOUN
bam-7218	467	11	of	of	ADP
bam-7218	467	12	h3k9	h3k9	X
bam-7218	467	13	kmts	kmts	VERB
bam-7218	467	14	specific	specific	ADJ
bam-7218	467	15	inhibitors	inhibitor	NOUN
bam-7218	467	16	as	as	ADP
bam-7218	467	17	potential	potential	ADJ
bam-7218	467	18	pharmacological	pharmacological	ADJ
bam-7218	467	19	strategy	strategy	NOUN
bam-7218	467	20	to	to	PART
bam-7218	467	21	promote	promote	VERB
bam-7218	467	22	the	the	DET
bam-7218	467	23	regenerative	regenerative	ADJ
bam-7218	467	24	response	response	NOUN
bam-7218	467	25	of	of	ADP
bam-7218	467	26	diseased	diseased	ADJ
bam-7218	467	27	,	,	PUNCT
bam-7218	467	28	dystrophic	dystrophic	ADJ
bam-7218	467	29	,	,	PUNCT
bam-7218	467	30	muscles	muscle	NOUN
bam-7218	467	31	,	,	PUNCT
bam-7218	467	32	while	while	SCONJ
bam-7218	467	33	concomitantly	concomitantly	ADV
bam-7218	467	34	blocking	block	VERB
bam-7218	467	35	their	their	PRON
bam-7218	467	36	fibro	fibro	NOUN
bam-7218	467	37	-	-	PUNCT
bam-7218	467	38	adipogenic	adipogenic	ADJ
bam-7218	467	39	degeneration	degeneration	NOUN
bam-7218	467	40	.	.	PUNCT
bam-7218	468	1	4.2	4.2	NUM
bam-7218	468	2	investigating	investigate	VERB
bam-7218	468	3	pathophysiological	pathophysiological	ADJ
bam-7218	468	4	mechanisms	mechanism	NOUN
bam-7218	468	5	of	of	ADP
bam-7218	468	6	the	the	DET
bam-7218	468	7	heart	heart	NOUN
bam-7218	468	8	in	in	ADP
bam-7218	468	9	dmd	dmd	PROPN
bam-7218	468	10	stephanie	stephanie	PROPN
bam-7218	468	11	carr	carr	PROPN
bam-7218	468	12	(	(	PUNCT
bam-7218	468	13	a	a	PROPN
bam-7218	468	14	)	)	PUNCT
bam-7218	468	15	,	,	PUNCT
bam-7218	468	16	morten	morten	PROPN
bam-7218	468	17	ritso	ritso	PROPN
bam-7218	468	18	(	(	PUNCT
bam-7218	468	19	a	a	PROPN
bam-7218	468	20	)	)	PUNCT
bam-7218	468	21	,	,	PUNCT
bam-7218	468	22	vietxuan	vietxuan	NOUN
bam-7218	468	23	phan	phan	PROPN
bam-7218	468	24	(	(	PUNCT
bam-7218	468	25	b	b	NOUN
bam-7218	468	26	)	)	PUNCT
bam-7218	468	27	,	,	PUNCT
bam-7218	468	28	theresa	theresa	PROPN
bam-7218	468	29	brand	brand	PROPN
bam-7218	468	30	(	(	PUNCT
bam-7218	468	31	b	b	NOUN
bam-7218	468	32	)	)	PUNCT
bam-7218	468	33	,	,	PUNCT
bam-7218	468	34	stefan	stefan	PROPN
bam-7218	468	35	krebs	krebs	PROPN
bam-7218	468	36	(	(	PUNCT
bam-7218	468	37	c	c	NOUN
bam-7218	468	38	)	)	PUNCT
bam-7218	468	39	,	,	PUNCT
bam-7218	468	40	alexander	alexander	PROPN
bam-7218	468	41	graf	graf	PROPN
bam-7218	468	42	(	(	PUNCT
bam-7218	468	43	3	3	NUM
bam-7218	468	44	)	)	PUNCT
bam-7218	468	45	,	,	PUNCT
bam-7218	468	46	helmut	helmut	PROPN
bam-7218	468	47	blum	blum	PROPN
bam-7218	468	48	(	(	PUNCT
bam-7218	468	49	3	3	NUM
bam-7218	468	50	)	)	PUNCT
bam-7218	468	51	,	,	PUNCT
bam-7218	468	52	andreas	andreas	PROPN
bam-7218	468	53	roos	roos	PROPN
bam-7218	468	54	(	(	PUNCT
bam-7218	468	55	a	a	DET
bam-7218	468	56	,	,	PUNCT
bam-7218	468	57	b	b	NOUN
bam-7218	468	58	)	)	PUNCT
bam-7218	468	59	,	,	PUNCT
bam-7218	468	60	kristina	kristina	PROPN
bam-7218	468	61	lorenz	lorenz	PROPN
bam-7218	468	62	(	(	PUNCT
bam-7218	468	63	b	b	NOUN
bam-7218	468	64	)	)	PUNCT
bam-7218	468	65	,	,	PUNCT
bam-7218	468	66	hanns	hann	NOUN
bam-7218	468	67	lochmϋller	lochmϋller	NOUN
bam-7218	468	68	(	(	PUNCT
bam-7218	468	69	a	a	NOUN
bam-7218	468	70	)	)	PUNCT
bam-7218	468	71	(	(	PUNCT
bam-7218	468	72	a	a	PRON
bam-7218	468	73	)	)	PUNCT
bam-7218	468	74	institute	institute	NOUN
bam-7218	468	75	of	of	ADP
bam-7218	468	76	genetic	genetic	ADJ
bam-7218	468	77	medicine	medicine	NOUN
bam-7218	468	78	,	,	PUNCT
bam-7218	468	79	newcastle	newcastle	PROPN
bam-7218	468	80	university	university	PROPN
bam-7218	468	81	,	,	PUNCT
bam-7218	468	82	uk	uk	PROPN
bam-7218	468	83	;	;	PUNCT
bam-7218	468	84	(	(	PUNCT
bam-7218	468	85	b	b	X
bam-7218	468	86	)	)	PUNCT
bam-7218	468	87	leibniz	leibniz	PROPN
bam-7218	468	88	-	-	PUNCT
bam-7218	468	89	institut	institut	PROPN
bam-7218	468	90	für	für	PROPN
bam-7218	468	91	analytische	analytische	PROPN
bam-7218	468	92	wissenschaften	wissenschaften	VERB
bam-7218	468	93	isas	isas	PROPN
bam-7218	468	94	v	v	PROPN
bam-7218	468	95	,	,	PUNCT
bam-7218	468	96	dortmund	dortmund	PROPN
bam-7218	468	97	;	;	PUNCT
bam-7218	468	98	(	(	PUNCT
bam-7218	468	99	c	c	X
bam-7218	468	100	)	)	PUNCT
bam-7218	468	101	3lafuga	3lafuga	NUM
bam-7218	468	102	genomics	genomic	NOUN
bam-7218	468	103	,	,	PUNCT
bam-7218	468	104	genzentrum	genzentrum	NOUN
bam-7218	468	105	,	,	PUNCT
bam-7218	468	106	universität	universität	PROPN
bam-7218	468	107	münchen	münchen	NOUN
bam-7218	468	108	(	(	PUNCT
bam-7218	468	109	lmu	lmu	PROPN
bam-7218	468	110	)	)	PUNCT
bam-7218	468	111	,	,	PUNCT
bam-7218	468	112	germany	germany	PROPN
bam-7218	468	113	.	.	PUNCT
bam-7218	469	1	e	e	X
bam-7218	469	2	-	-	NOUN
bam-7218	469	3	mail	mail	NOUN
bam-7218	469	4	:	:	PUNCT
bam-7218	469	5	s.carr2@ncl.ac.uk	s.carr2@ncl.ac.uk	VERB
bam-7218	469	6	several	several	ADJ
bam-7218	469	7	therapies	therapy	NOUN
bam-7218	469	8	to	to	PART
bam-7218	469	9	treat	treat	VERB
bam-7218	469	10	duchenne	duchenne	NOUN
bam-7218	469	11	muscular	muscular	ADJ
bam-7218	469	12	dystrophy	dystrophy	NOUN
bam-7218	469	13	(	(	PUNCT
bam-7218	469	14	dmd	dmd	NOUN
bam-7218	469	15	)	)	PUNCT
bam-7218	469	16	are	be	AUX
bam-7218	469	17	under	under	ADP
bam-7218	469	18	development	development	NOUN
bam-7218	469	19	;	;	PUNCT
bam-7218	469	20	unfortunately	unfortunately	ADV
bam-7218	469	21	many	many	ADJ
bam-7218	469	22	lack	lack	VERB
bam-7218	469	23	efficacy	efficacy	NOUN
bam-7218	469	24	in	in	ADP
bam-7218	469	25	the	the	DET
bam-7218	469	26	heart	heart	NOUN
bam-7218	469	27	.	.	PUNCT
bam-7218	470	1	despite	despite	SCONJ
bam-7218	470	2	the	the	DET
bam-7218	470	3	primary	primary	ADJ
bam-7218	470	4	genetic	genetic	ADJ
bam-7218	470	5	defect	defect	NOUN
bam-7218	470	6	being	be	AUX
bam-7218	470	7	identical	identical	ADJ
bam-7218	470	8	in	in	ADP
bam-7218	470	9	skeletal	skeletal	ADJ
bam-7218	470	10	and	and	CCONJ
bam-7218	470	11	cardiac	cardiac	ADJ
bam-7218	470	12	muscle	muscle	NOUN
bam-7218	470	13	,	,	PUNCT
bam-7218	470	14	the	the	DET
bam-7218	470	15	symptoms	symptom	NOUN
bam-7218	470	16	and	and	CCONJ
bam-7218	470	17	severity	severity	NOUN
bam-7218	470	18	differ	differ	VERB
bam-7218	470	19	suggesting	suggest	VERB
bam-7218	470	20	the	the	DET
bam-7218	470	21	involvement	involvement	NOUN
bam-7218	470	22	of	of	ADP
bam-7218	470	23	secondary	secondary	ADJ
bam-7218	470	24	organ	organ	NOUN
bam-7218	470	25	-	-	PUNCT
bam-7218	470	26	specific	specific	ADJ
bam-7218	470	27	pathways	pathway	NOUN
bam-7218	470	28	that	that	PRON
bam-7218	470	29	are	be	AUX
bam-7218	470	30	yet	yet	ADV
bam-7218	470	31	to	to	PART
bam-7218	470	32	be	be	AUX
bam-7218	470	33	fully	fully	ADV
bam-7218	470	34	understood	understand	VERB
bam-7218	470	35	.	.	PUNCT
bam-7218	471	1	we	we	PRON
bam-7218	471	2	have	have	AUX
bam-7218	471	3	developed	develop	VERB
bam-7218	471	4	an	an	DET
bam-7218	471	5	in	in	X
bam-7218	471	6	vitro	vitro	X
bam-7218	471	7	model	model	NOUN
bam-7218	471	8	of	of	ADP
bam-7218	471	9	cardiomyocyte	cardiomyocyte	PROPN
bam-7218	471	10	hypertrophy	hypertrophy	NOUN
bam-7218	471	11	using	use	VERB
bam-7218	471	12	cardiomyocytes	cardiomyocyte	NOUN
bam-7218	471	13	isolated	isolate	VERB
bam-7218	471	14	from	from	ADP
bam-7218	471	15	mdx	mdx	NOUN
bam-7218	471	16	(	(	PUNCT
bam-7218	471	17	mouse	mouse	NOUN
bam-7218	471	18	model	model	NOUN
bam-7218	471	19	of	of	ADP
bam-7218	471	20	dmd	dmd	NOUN
bam-7218	471	21	)	)	PUNCT
bam-7218	471	22	hearts	heart	NOUN
bam-7218	471	23	.	.	PUNCT
bam-7218	472	1	additionally	additionally	ADV
bam-7218	472	2	,	,	PUNCT
bam-7218	472	3	a	a	DET
bam-7218	472	4	transcriptomic	transcriptomic	ADJ
bam-7218	472	5	approach	approach	NOUN
bam-7218	472	6	has	have	AUX
bam-7218	472	7	been	be	AUX
bam-7218	472	8	applied	apply	VERB
bam-7218	472	9	to	to	ADP
bam-7218	472	10	this	this	DET
bam-7218	472	11	model	model	NOUN
bam-7218	472	12	,	,	PUNCT
bam-7218	472	13	to	to	PART
bam-7218	472	14	help	help	VERB
bam-7218	472	15	elucidate	elucidate	VERB
bam-7218	472	16	the	the	DET
bam-7218	472	17	secondary	secondary	ADJ
bam-7218	472	18	organ	organ	NOUN
bam-7218	472	19	-	-	PUNCT
bam-7218	472	20	specific	specific	ADJ
bam-7218	472	21	pathways	pathway	NOUN
bam-7218	472	22	involved	involve	VERB
bam-7218	472	23	.	.	PUNCT
bam-7218	473	1	proteomic	proteomic	ADJ
bam-7218	473	2	analysis	analysis	NOUN
bam-7218	473	3	of	of	ADP
bam-7218	473	4	25	25	NUM
bam-7218	473	5	week	week	NOUN
bam-7218	473	6	-	-	PUNCT
bam-7218	473	7	old	old	ADJ
bam-7218	473	8	mdx	mdx	NOUN
bam-7218	473	9	hearts	heart	NOUN
bam-7218	473	10	was	be	AUX
bam-7218	473	11	carried	carry	VERB
bam-7218	473	12	out	out	ADP
bam-7218	473	13	to	to	PART
bam-7218	473	14	identify	identify	VERB
bam-7218	473	15	changes	change	NOUN
bam-7218	473	16	in	in	ADP
bam-7218	473	17	the	the	DET
bam-7218	473	18	early	early	ADJ
bam-7218	473	19	stage	stage	NOUN
bam-7218	473	20	of	of	ADP
bam-7218	473	21	the	the	DET
bam-7218	473	22	disease	disease	NOUN
bam-7218	473	23	.	.	PUNCT
bam-7218	474	1	using	use	VERB
bam-7218	474	2	this	this	DET
bam-7218	474	3	model	model	NOUN
bam-7218	474	4	,	,	PUNCT
bam-7218	474	5	we	we	PRON
bam-7218	474	6	have	have	AUX
bam-7218	474	7	been	be	AUX
bam-7218	474	8	able	able	ADJ
bam-7218	474	9	to	to	PART
bam-7218	474	10	utilise	utilise	VERB
bam-7218	474	11	various	various	ADJ
bam-7218	474	12	therapeutic	therapeutic	ADJ
bam-7218	474	13	approaches	approach	NOUN
bam-7218	474	14	to	to	PART
bam-7218	474	15	lessen	lessen	VERB
bam-7218	474	16	the	the	DET
bam-7218	474	17	severity	severity	NOUN
bam-7218	474	18	of	of	ADP
bam-7218	474	19	the	the	DET
bam-7218	474	20	phenotype	phenotype	NOUN
bam-7218	474	21	.	.	PUNCT
bam-7218	475	1	this	this	DET
bam-7218	475	2	model	model	NOUN
bam-7218	475	3	could	could	AUX
bam-7218	475	4	be	be	AUX
bam-7218	475	5	a	a	DET
bam-7218	475	6	fast	fast	ADJ
bam-7218	475	7	,	,	PUNCT
bam-7218	475	8	efficient	efficient	ADJ
bam-7218	475	9	way	way	NOUN
bam-7218	475	10	to	to	PART
bam-7218	475	11	screen	screen	VERB
bam-7218	475	12	new	new	ADJ
bam-7218	475	13	and	and	CCONJ
bam-7218	475	14	existing	exist	VERB
bam-7218	475	15	approaches	approach	NOUN
bam-7218	475	16	for	for	ADP
bam-7218	475	17	therapeutic	therapeutic	ADJ
bam-7218	475	18	efficacy	efficacy	NOUN
bam-7218	475	19	.	.	PUNCT
bam-7218	476	1	restoration	restoration	NOUN
bam-7218	476	2	of	of	ADP
bam-7218	476	3	truncated	truncated	ADJ
bam-7218	476	4	dystrophin	dystrophin	ADJ
bam-7218	476	5	protein	protein	NOUN
bam-7218	476	6	to	to	ADP
bam-7218	476	7	these	these	DET
bam-7218	476	8	cells	cell	NOUN
bam-7218	476	9	via	via	ADP
bam-7218	476	10	a	a	DET
bam-7218	476	11	viral	viral	ADJ
bam-7218	476	12	vector	vector	NOUN
bam-7218	476	13	rescues	rescue	NOUN
bam-7218	476	14	the	the	DET
bam-7218	476	15	hypertrophic	hypertrophic	ADJ
bam-7218	476	16	phenotype	phenotype	NOUN
bam-7218	476	17	in	in	ADP
bam-7218	476	18	addition	addition	NOUN
bam-7218	476	19	to	to	ADP
bam-7218	476	20	the	the	DET
bam-7218	476	21	application	application	NOUN
bam-7218	476	22	of	of	ADP
bam-7218	476	23	pharmaceutical	pharmaceutical	NOUN
bam-7218	476	24	compounds	compound	NOUN
bam-7218	476	25	.	.	PUNCT
bam-7218	477	1	rna	rna	NOUN
bam-7218	477	2	-	-	PUNCT
bam-7218	477	3	seq	seq	NOUN
bam-7218	477	4	data	datum	NOUN
bam-7218	477	5	from	from	ADP
bam-7218	477	6	the	the	DET
bam-7218	477	7	hypertrophic	hypertrophic	ADJ
bam-7218	477	8	cardiomyocytes	cardiomyocyte	NOUN
bam-7218	477	9	implicated	implicate	VERB
bam-7218	477	10	the	the	DET
bam-7218	477	11	involvement	involvement	NOUN
bam-7218	477	12	of	of	ADP
bam-7218	477	13	pathways	pathway	NOUN
bam-7218	477	14	such	such	ADJ
bam-7218	477	15	as	as	ADP
bam-7218	477	16	angiogenesis	angiogenesis	NOUN
bam-7218	477	17	,	,	PUNCT
bam-7218	477	18	fibrosis	fibrosis	NOUN
bam-7218	477	19	and	and	CCONJ
bam-7218	477	20	calcium	calcium	NOUN
bam-7218	477	21	handling	handling	NOUN
bam-7218	477	22	.	.	PUNCT
bam-7218	478	1	using	use	VERB
bam-7218	478	2	data	datum	NOUN
bam-7218	478	3	generated	generate	VERB
bam-7218	478	4	from	from	ADP
bam-7218	478	5	transcriptomics	transcriptomic	NOUN
bam-7218	478	6	,	,	PUNCT
bam-7218	478	7	differentially	differentially	ADV
bam-7218	478	8	regulated	regulate	VERB
bam-7218	478	9	transcripts	transcript	NOUN
bam-7218	478	10	were	be	AUX
bam-7218	478	11	targeted	target	VERB
bam-7218	478	12	for	for	ADP
bam-7218	478	13	investigation	investigation	NOUN
bam-7218	478	14	on	on	ADP
bam-7218	478	15	a	a	DET
bam-7218	478	16	protein	protein	NOUN
bam-7218	478	17	level	level	NOUN
bam-7218	478	18	.	.	PUNCT
bam-7218	479	1	data	datum	NOUN
bam-7218	479	2	from	from	ADP
bam-7218	479	3	proteomic	proteomic	ADJ
bam-7218	479	4	analysis	analysis	NOUN
bam-7218	479	5	of	of	ADP
bam-7218	479	6	mdx	mdx	NOUN
bam-7218	479	7	hearts	heart	NOUN
bam-7218	479	8	revealed	reveal	VERB
bam-7218	479	9	perturbations	perturbation	NOUN
bam-7218	479	10	in	in	ADP
bam-7218	479	11	the	the	DET
bam-7218	479	12	immune	immune	ADJ
bam-7218	479	13	response	response	NOUN
bam-7218	479	14	and	and	CCONJ
bam-7218	479	15	actin	actin	NOUN
bam-7218	479	16	regulation	regulation	NOUN
bam-7218	479	17	.	.	PUNCT
bam-7218	480	1	identification	identification	NOUN
bam-7218	480	2	of	of	ADP
bam-7218	480	3	genes	gene	NOUN
bam-7218	480	4	,	,	PUNCT
bam-7218	480	5	proteins	protein	NOUN
bam-7218	480	6	and	and	CCONJ
bam-7218	480	7	pathways	pathway	NOUN
bam-7218	480	8	differentially	differentially	ADV
bam-7218	480	9	regulated	regulate	VERB
bam-7218	480	10	in	in	ADP
bam-7218	480	11	the	the	DET
bam-7218	480	12	mdx	mdx	NOUN
bam-7218	480	13	heart	heart	NOUN
bam-7218	480	14	provides	provide	VERB
bam-7218	480	15	novel	novel	ADJ
bam-7218	480	16	insights	insight	NOUN
bam-7218	480	17	into	into	ADP
bam-7218	480	18	the	the	DET
bam-7218	480	19	cellular	cellular	ADJ
bam-7218	480	20	pathophysiology	pathophysiology	NOUN
bam-7218	480	21	of	of	ADP
bam-7218	480	22	this	this	DET
bam-7218	480	23	organ	organ	NOUN
bam-7218	480	24	in	in	ADP
bam-7218	480	25	dmd	dmd	NOUN
bam-7218	480	26	and	and	CCONJ
bam-7218	480	27	allows	allow	VERB
bam-7218	480	28	the	the	DET
bam-7218	480	29	identification	identification	NOUN
bam-7218	480	30	of	of	ADP
bam-7218	480	31	potential	potential	ADJ
bam-7218	480	32	therapeutic	therapeutic	ADJ
bam-7218	480	33	targets	target	NOUN
bam-7218	480	34	.	.	PUNCT
bam-7218	481	1	4.3	4.3	NUM
bam-7218	481	2	the	the	DET
bam-7218	481	3	polycomb	polycomb	PROPN
bam-7218	481	4	ezh2	ezh2	PROPN
bam-7218	481	5	chromatin	chromatin	NOUN
bam-7218	481	6	modifier	modifier	NOUN
bam-7218	481	7	modulates	modulate	NOUN
bam-7218	481	8	chronic	chronic	ADJ
bam-7218	481	9	muscle	muscle	NOUN
bam-7218	481	10	fibrosis	fibrosis	NOUN
bam-7218	481	11	by	by	ADP
bam-7218	481	12	repressing	repress	VERB
bam-7218	481	13	fibro	fibro	NOUN
bam-7218	481	14	-	-	PUNCT
bam-7218	481	15	adipogenic	adipogenic	ADJ
bam-7218	481	16	progenitors	progenitor	NOUN
bam-7218	481	17	’	'	PUNCT
bam-7218	481	18	expansion	expansion	NOUN
bam-7218	481	19	alessandra	alessandra	PROPN
bam-7218	481	20	pasut	pasut	PROPN
bam-7218	481	21	(	(	PUNCT
bam-7218	481	22	a	a	PROPN
bam-7218	481	23	)	)	PUNCT
bam-7218	481	24	,	,	PUNCT
bam-7218	481	25	marcella	marcella	PROPN
bam-7218	481	26	low	low	PROPN
bam-7218	481	27	manilla	manilla	X
bam-7218	481	28	(	(	PUNCT
bam-7218	481	29	b	b	NOUN
bam-7218	481	30	)	)	PUNCT
bam-7218	481	31	,	,	PUNCT
bam-7218	481	32	eusebio	eusebio	NOUN
bam-7218	481	33	perdiguero	perdiguero	NOUN
bam-7218	481	34	(	(	PUNCT
bam-7218	481	35	c	c	NOUN
bam-7218	481	36	)	)	PUNCT
bam-7218	481	37	,	,	PUNCT
bam-7218	481	38	pura	pura	PROPN
bam-7218	481	39	muñoz	muñoz	PROPN
bam-7218	481	40	-	-	PUNCT
bam-7218	481	41	cánoves	cánove	NOUN
bam-7218	481	42	(	(	PUNCT
bam-7218	481	43	c	c	NOUN
bam-7218	481	44	)	)	PUNCT
bam-7218	481	45	,	,	PUNCT
bam-7218	481	46	fabio	fabio	PROPN
bam-7218	481	47	rossi	rossi	PROPN
bam-7218	481	48	(	(	PUNCT
bam-7218	481	49	b	b	NOUN
bam-7218	481	50	)	)	PUNCT
bam-7218	481	51	,	,	PUNCT
bam-7218	481	52	vittorio	vittorio	PROPN
bam-7218	481	53	sartorelli	sartorelli	PROPN
bam-7218	481	54	(	(	PUNCT
bam-7218	481	55	a	a	NOUN
bam-7218	481	56	)	)	PUNCT
bam-7218	481	57	(	(	PUNCT
bam-7218	481	58	a	a	X
bam-7218	481	59	)	)	PUNCT
bam-7218	481	60	national	national	PROPN
bam-7218	481	61	institute	institute	PROPN
bam-7218	481	62	of	of	ADP
bam-7218	481	63	health	health	PROPN
bam-7218	481	64	,	,	PUNCT
bam-7218	481	65	niams	niam	NOUN
bam-7218	481	66	,	,	PUNCT
bam-7218	481	67	bethesda	bethesda	PROPN
bam-7218	481	68	,	,	PUNCT
bam-7218	481	69	md	md	PROPN
bam-7218	481	70	,	,	PUNCT
bam-7218	481	71	usa	usa	PROPN
bam-7218	481	72	.	.	PROPN
bam-7218	481	73	(	(	PUNCT
bam-7218	481	74	b	b	X
bam-7218	481	75	)	)	PUNCT
bam-7218	481	76	biomedical	biomedical	ADJ
bam-7218	481	77	research	research	NOUN
bam-7218	481	78	center	center	NOUN
bam-7218	481	79	,	,	PUNCT
bam-7218	481	80	university	university	NOUN
bam-7218	481	81	of	of	ADP
bam-7218	481	82	british	british	PROPN
bam-7218	481	83	columbia	columbia	PROPN
bam-7218	481	84	,	,	PUNCT
bam-7218	481	85	vancouver	vancouver	PROPN
bam-7218	481	86	,	,	PUNCT
bam-7218	481	87	bc	bc	PROPN
bam-7218	481	88	,	,	PUNCT
bam-7218	481	89	canada	canada	PROPN
bam-7218	481	90	.	.	PUNCT
bam-7218	482	1	(	(	PUNCT
bam-7218	482	2	c	c	X
bam-7218	482	3	)	)	PUNCT
bam-7218	482	4	dept	dept	NOUN
bam-7218	482	5	of	of	ADP
bam-7218	482	6	experimental	experimental	ADJ
bam-7218	482	7	and	and	CCONJ
bam-7218	482	8	health	health	NOUN
bam-7218	482	9	science	science	NOUN
bam-7218	482	10	.	.	PUNCT
bam-7218	483	1	pompeu	pompeu	PROPN
bam-7218	483	2	fabra	fabra	VERB
bam-7218	483	3	university	university	PROPN
bam-7218	483	4	,	,	PUNCT
bam-7218	483	5	barcelona	barcelona	PROPN
bam-7218	483	6	,	,	PUNCT
bam-7218	483	7	spain	spain	PROPN
bam-7218	483	8	.	.	PUNCT
bam-7218	484	1	e	e	X
bam-7218	484	2	-	-	NOUN
bam-7218	484	3	mail	mail	NOUN
bam-7218	484	4	:	:	PUNCT
bam-7218	484	5	alessandra.pasut@nih.gov	alessandra.pasut@nih.gov	NOUN
bam-7218	484	6	in	in	ADP
bam-7218	484	7	the	the	DET
bam-7218	484	8	adult	adult	NOUN
bam-7218	484	9	muscle	muscle	NOUN
bam-7218	484	10	the	the	DET
bam-7218	484	11	process	process	NOUN
bam-7218	484	12	of	of	ADP
bam-7218	484	13	regeneration	regeneration	NOUN
bam-7218	484	14	is	be	AUX
bam-7218	484	15	necessary	necessary	ADJ
bam-7218	484	16	to	to	PART
bam-7218	484	17	replace	replace	VERB
bam-7218	484	18	and	and	CCONJ
bam-7218	484	19	rebuild	rebuild	VERB
bam-7218	484	20	mature	mature	ADJ
bam-7218	484	21	fibers	fiber	NOUN
bam-7218	484	22	.	.	PUNCT
bam-7218	485	1	following	follow	VERB
bam-7218	485	2	a	a	DET
bam-7218	485	3	muscle	muscle	NOUN
bam-7218	485	4	injury	injury	NOUN
bam-7218	485	5	,	,	PUNCT
bam-7218	485	6	inflammatory	inflammatory	ADJ
bam-7218	485	7	cells	cell	NOUN
bam-7218	485	8	and	and	CCONJ
bam-7218	485	9	tissue	tissue	NOUN
bam-7218	485	10	resident	resident	NOUN
bam-7218	485	11	fibroblasts	fibroblast	NOUN
bam-7218	485	12	are	be	AUX
bam-7218	485	13	recruited	recruit	VERB
bam-7218	485	14	to	to	ADP
bam-7218	485	15	the	the	DET
bam-7218	485	16	site	site	NOUN
bam-7218	485	17	of	of	ADP
bam-7218	485	18	injury	injury	NOUN
bam-7218	485	19	where	where	SCONJ
bam-7218	485	20	,	,	PUNCT
bam-7218	485	21	among	among	ADP
bam-7218	485	22	other	other	ADJ
bam-7218	485	23	functions	function	NOUN
bam-7218	485	24	,	,	PUNCT
bam-7218	485	25	they	they	PRON
bam-7218	485	26	contribute	contribute	VERB
bam-7218	485	27	to	to	ADP
bam-7218	485	28	the	the	DET
bam-7218	485	29	remodeling	remodeling	NOUN
bam-7218	485	30	of	of	ADP
bam-7218	485	31	the	the	DET
bam-7218	485	32	extra	extra	ADJ
bam-7218	485	33	cellular	cellular	ADJ
bam-7218	485	34	matrix	matrix	NOUN
bam-7218	485	35	(	(	PUNCT
bam-7218	485	36	ecm	ecm	PROPN
bam-7218	485	37	)	)	PUNCT
bam-7218	485	38	,	,	PUNCT
bam-7218	485	39	a	a	DET
bam-7218	485	40	process	process	NOUN
bam-7218	485	41	known	know	VERB
bam-7218	485	42	as	as	ADP
bam-7218	485	43	reparative	reparative	ADJ
bam-7218	485	44	fibrosis	fibrosis	NOUN
bam-7218	485	45	.	.	PUNCT
bam-7218	486	1	faps	fap	NOUN
bam-7218	486	2	(	(	PUNCT
bam-7218	486	3	fibroadipogenic	fibroadipogenic	ADJ
bam-7218	486	4	progenitors	progenitor	NOUN
bam-7218	486	5	)	)	PUNCT
bam-7218	486	6	are	be	AUX
bam-7218	486	7	thought	think	VERB
bam-7218	486	8	to	to	PART
bam-7218	486	9	be	be	AUX
bam-7218	486	10	the	the	DET
bam-7218	486	11	main	main	ADJ
bam-7218	486	12	source	source	NOUN
bam-7218	486	13	of	of	ADP
bam-7218	486	14	matrix	matrix	NOUN
bam-7218	486	15	producing	produce	VERB
bam-7218	486	16	cells	cell	NOUN
bam-7218	486	17	in	in	ADP
bam-7218	486	18	skeletal	skeletal	ADJ
bam-7218	486	19	muscle	muscle	NOUN
bam-7218	486	20	.	.	PUNCT
bam-7218	487	1	in	in	ADP
bam-7218	487	2	mailto:valeria.bianconi@uniroma1.it	mailto:valeria.bianconi@uniroma1.it	PROPN
bam-7218	487	3	mailto:s.carr2@ncl.ac.uk	mailto:s.carr2@ncl.ac.uk	NOUN
bam-7218	487	4	mailto:alessandra.pasut@nih.gov	mailto:alessandra.pasut@nih.gov	VERB
bam-7218	487	5	14	14	NUM
bam-7218	487	6	th	th	NUM
bam-7218	487	7	iiim	iiim	NOUN
bam-7218	487	8	meeting	meeting	NOUN
bam-7218	487	9	,	,	PUNCT
bam-7218	487	10	assisi	assisi	PROPN
bam-7218	487	11	,	,	PUNCT
bam-7218	487	12	italy	italy	PROPN
bam-7218	487	13	october	october	PROPN
bam-7218	487	14	12	12	NUM
bam-7218	487	15	-	-	SYM
bam-7218	487	16	15	15	NUM
bam-7218	487	17	2017	2017	NUM
bam-7218	487	18	eur	eur	PROPN
bam-7218	487	19	j	j	PROPN
bam-7218	487	20	transl	transl	PROPN
bam-7218	487	21	myol	myol	ADV
bam-7218	487	22	27	27	NUM
bam-7218	487	23	(	(	PUNCT
bam-7218	487	24	4	4	NUM
bam-7218	487	25	):	):	SYM
bam-7218	487	26	185	185	NUM
bam-7218	487	27	-	-	SYM
bam-7218	487	28	224	224	NUM
bam-7218	487	29	199	199	NUM
bam-7218	487	30	conditions	condition	NOUN
bam-7218	487	31	of	of	ADP
bam-7218	487	32	chronic	chronic	ADJ
bam-7218	487	33	or	or	CCONJ
bam-7218	487	34	unresolved	unresolved	ADJ
bam-7218	487	35	muscle	muscle	NOUN
bam-7218	487	36	damage	damage	NOUN
bam-7218	487	37	,	,	PUNCT
bam-7218	487	38	aging	aging	NOUN
bam-7218	487	39	,	,	PUNCT
bam-7218	487	40	or	or	CCONJ
bam-7218	487	41	muscular	muscular	ADJ
bam-7218	487	42	dystrophies	dystrophy	NOUN
bam-7218	487	43	,	,	PUNCT
bam-7218	487	44	faps	fap	NOUN
bam-7218	487	45	persist	persist	VERB
bam-7218	487	46	and	and	CCONJ
bam-7218	487	47	cause	cause	VERB
bam-7218	487	48	excessive	excessive	ADJ
bam-7218	487	49	scar	scar	ADJ
bam-7218	487	50	tissue	tissue	NOUN
bam-7218	487	51	and/or	and/or	CCONJ
bam-7218	487	52	ectopic	ectopic	VERB
bam-7218	487	53	fat	fat	ADJ
bam-7218	487	54	infiltration	infiltration	NOUN
bam-7218	487	55	,	,	PUNCT
bam-7218	487	56	ultimately	ultimately	ADV
bam-7218	487	57	responsible	responsible	ADJ
bam-7218	487	58	for	for	ADP
bam-7218	487	59	the	the	DET
bam-7218	487	60	progressive	progressive	ADJ
bam-7218	487	61	decline	decline	NOUN
bam-7218	487	62	of	of	ADP
bam-7218	487	63	muscle	muscle	NOUN
bam-7218	487	64	function	function	NOUN
bam-7218	487	65	.	.	PUNCT
bam-7218	488	1	here	here	ADV
bam-7218	488	2	we	we	PRON
bam-7218	488	3	identify	identify	VERB
bam-7218	488	4	a	a	DET
bam-7218	488	5	novel	novel	ADJ
bam-7218	488	6	mechanism	mechanism	NOUN
bam-7218	488	7	by	by	ADP
bam-7218	488	8	which	which	PRON
bam-7218	488	9	the	the	DET
bam-7218	488	10	polycomb	polycomb	ADJ
bam-7218	488	11	ezh2	ezh2	NOUN
bam-7218	488	12	chromatin	chromatin	NOUN
bam-7218	488	13	modifier	modifier	NOUN
bam-7218	488	14	modulates	modulate	VERB
bam-7218	488	15	the	the	DET
bam-7218	488	16	number	number	NOUN
bam-7218	488	17	and	and	CCONJ
bam-7218	488	18	proliferation	proliferation	NOUN
bam-7218	488	19	of	of	ADP
bam-7218	488	20	faps	fap	NOUN
bam-7218	488	21	within	within	ADP
bam-7218	488	22	skeletal	skeletal	ADJ
bam-7218	488	23	muscle	muscle	NOUN
bam-7218	488	24	through	through	ADP
bam-7218	488	25	the	the	DET
bam-7218	488	26	repression	repression	NOUN
bam-7218	488	27	of	of	ADP
bam-7218	488	28	several	several	ADJ
bam-7218	488	29	profibrotic	profibrotic	ADJ
bam-7218	488	30	cytokines	cytokine	NOUN
bam-7218	488	31	secreted	secrete	VERB
bam-7218	488	32	into	into	ADP
bam-7218	488	33	the	the	DET
bam-7218	488	34	extracellular	extracellular	ADJ
bam-7218	488	35	space	space	NOUN
bam-7218	488	36	.	.	PUNCT
bam-7218	489	1	we	we	PRON
bam-7218	489	2	found	find	VERB
bam-7218	489	3	that	that	SCONJ
bam-7218	489	4	specific	specific	ADJ
bam-7218	489	5	deletion	deletion	NOUN
bam-7218	489	6	of	of	ADP
bam-7218	489	7	ezh2	ezh2	NOUN
bam-7218	489	8	in	in	ADP
bam-7218	489	9	satellite	satellite	NOUN
bam-7218	489	10	cells	cell	NOUN
bam-7218	489	11	results	result	NOUN
bam-7218	489	12	in	in	ADP
bam-7218	489	13	the	the	DET
bam-7218	489	14	accumulation	accumulation	NOUN
bam-7218	489	15	and	and	CCONJ
bam-7218	489	16	hyperproliferation	hyperproliferation	NOUN
bam-7218	489	17	of	of	ADP
bam-7218	489	18	faps	fap	NOUN
bam-7218	489	19	in	in	ADP
bam-7218	489	20	adult	adult	NOUN
bam-7218	489	21	and	and	CCONJ
bam-7218	489	22	aged	aged	ADJ
bam-7218	489	23	muscles	muscle	NOUN
bam-7218	489	24	.	.	PUNCT
bam-7218	490	1	transcriptome	transcriptome	ADJ
bam-7218	490	2	studies	study	NOUN
bam-7218	490	3	showed	show	VERB
bam-7218	490	4	that	that	SCONJ
bam-7218	490	5	component	component	NOUN
bam-7218	490	6	of	of	ADP
bam-7218	490	7	the	the	DET
bam-7218	490	8	tgfb	tgfb	NOUN
bam-7218	490	9	,	,	PUNCT
bam-7218	490	10	wnt	wnt	PROPN
bam-7218	490	11	,	,	PUNCT
bam-7218	490	12	tnf	tnf	PROPN
bam-7218	490	13	-	-	PUNCT
bam-7218	490	14	alpha	alpha	NOUN
bam-7218	490	15	and	and	CCONJ
bam-7218	490	16	pdgf	pdgf	PROPN
bam-7218	490	17	signaling	signaling	NOUN
bam-7218	490	18	are	be	AUX
bam-7218	490	19	expressed	express	VERB
bam-7218	490	20	at	at	ADP
bam-7218	490	21	higher	high	ADJ
bam-7218	490	22	level	level	NOUN
bam-7218	490	23	in	in	ADP
bam-7218	490	24	ezh2	ezh2	NOUN
bam-7218	490	25	knock	knock	VERB
bam-7218	490	26	out	out	ADP
bam-7218	490	27	satellite	satellite	NOUN
bam-7218	490	28	cells	cell	NOUN
bam-7218	490	29	,	,	PUNCT
bam-7218	490	30	escaping	escape	VERB
bam-7218	490	31	ezh2	ezh2	NOUN
bam-7218	490	32	mediated	mediate	VERB
bam-7218	490	33	repression	repression	NOUN
bam-7218	490	34	and	and	CCONJ
bam-7218	490	35	are	be	AUX
bam-7218	490	36	also	also	ADV
bam-7218	490	37	found	find	VERB
bam-7218	490	38	up	up	ADV
bam-7218	490	39	-	-	PUNCT
bam-7218	490	40	regulated	regulated	ADJ
bam-7218	490	41	in	in	ADP
bam-7218	490	42	aged	aged	ADJ
bam-7218	490	43	satellite	satellite	NOUN
bam-7218	490	44	cells	cell	NOUN
bam-7218	490	45	.	.	PUNCT
bam-7218	491	1	inhibition	inhibition	NOUN
bam-7218	491	2	of	of	ADP
bam-7218	491	3	these	these	DET
bam-7218	491	4	signaling	signal	VERB
bam-7218	491	5	is	be	AUX
bam-7218	491	6	sufficient	sufficient	ADJ
bam-7218	491	7	to	to	PART
bam-7218	491	8	block	block	VERB
bam-7218	491	9	faps	fap	NOUN
bam-7218	491	10	proliferation	proliferation	NOUN
bam-7218	491	11	.	.	PUNCT
bam-7218	492	1	importantly	importantly	ADV
bam-7218	492	2	treatment	treatment	NOUN
bam-7218	492	3	of	of	ADP
bam-7218	492	4	aged	aged	ADJ
bam-7218	492	5	faps	fap	NOUN
bam-7218	492	6	with	with	ADP
bam-7218	492	7	supernatant	supernatant	NOUN
bam-7218	492	8	isolated	isolate	VERB
bam-7218	492	9	from	from	ADP
bam-7218	492	10	young	young	ADJ
bam-7218	492	11	wild	wild	ADJ
bam-7218	492	12	type	type	NOUN
bam-7218	492	13	satellite	satellite	NOUN
bam-7218	492	14	cells	cell	NOUN
bam-7218	492	15	rescue	rescue	VERB
bam-7218	492	16	the	the	DET
bam-7218	492	17	aged	aged	ADJ
bam-7218	492	18	faps	fap	NOUN
bam-7218	492	19	phenotype	phenotype	NOUN
bam-7218	492	20	,	,	PUNCT
bam-7218	492	21	providign	providign	VERB
bam-7218	492	22	further	further	ADJ
bam-7218	492	23	evidence	evidence	NOUN
bam-7218	492	24	that	that	SCONJ
bam-7218	492	25	satellite	satellite	NOUN
bam-7218	492	26	cells	cell	NOUN
bam-7218	492	27	modulate	modulate	VERB
bam-7218	492	28	the	the	DET
bam-7218	492	29	production	production	NOUN
bam-7218	492	30	of	of	ADP
bam-7218	492	31	fibrogenic	fibrogenic	ADJ
bam-7218	492	32	cells	cell	NOUN
bam-7218	492	33	in	in	ADP
bam-7218	492	34	a	a	DET
bam-7218	492	35	paracrine	paracrine	ADJ
bam-7218	492	36	fashion	fashion	NOUN
bam-7218	492	37	.	.	PUNCT
bam-7218	493	1	altogether	altogether	ADV
bam-7218	493	2	these	these	DET
bam-7218	493	3	results	result	NOUN
bam-7218	493	4	show	show	VERB
bam-7218	493	5	that	that	SCONJ
bam-7218	493	6	epigenetic	epigenetic	ADJ
bam-7218	493	7	changes	change	NOUN
bam-7218	493	8	driven	drive	VERB
bam-7218	493	9	by	by	ADP
bam-7218	493	10	ezh2	ezh2	NOUN
bam-7218	493	11	in	in	ADP
bam-7218	493	12	satellite	satellite	NOUN
bam-7218	493	13	cells	cell	NOUN
bam-7218	493	14	result	result	VERB
bam-7218	493	15	in	in	ADP
bam-7218	493	16	functional	functional	ADJ
bam-7218	493	17	changes	change	NOUN
bam-7218	493	18	in	in	ADP
bam-7218	493	19	the	the	DET
bam-7218	493	20	muscle	muscle	NOUN
bam-7218	493	21	niche	niche	NOUN
bam-7218	493	22	and	and	CCONJ
bam-7218	493	23	point	point	VERB
bam-7218	493	24	to	to	ADP
bam-7218	493	25	a	a	DET
bam-7218	493	26	role	role	NOUN
bam-7218	493	27	for	for	ADP
bam-7218	493	28	ezh2	ezh2	NOUN
bam-7218	493	29	in	in	ADP
bam-7218	493	30	regulating	regulate	VERB
bam-7218	493	31	persistent	persistent	ADJ
bam-7218	493	32	fibrosis	fibrosis	NOUN
bam-7218	493	33	during	during	ADP
bam-7218	493	34	aging	aging	NOUN
bam-7218	493	35	.	.	PUNCT
bam-7218	494	1	modulation	modulation	NOUN
bam-7218	494	2	of	of	ADP
bam-7218	494	3	satellite	satellite	NOUN
bam-7218	494	4	cells	cell	NOUN
bam-7218	494	5	epigenetics	epigenetic	NOUN
bam-7218	494	6	and	and	CCONJ
bam-7218	494	7	specifically	specifically	ADV
bam-7218	494	8	ezh2	ezh2	ADJ
bam-7218	494	9	acitivity	acitivity	NOUN
bam-7218	494	10	may	may	AUX
bam-7218	494	11	therefore	therefore	ADV
bam-7218	494	12	offer	offer	VERB
bam-7218	494	13	an	an	DET
bam-7218	494	14	additional	additional	ADJ
bam-7218	494	15	therapeutic	therapeutic	ADJ
bam-7218	494	16	route	route	NOUN
bam-7218	494	17	for	for	ADP
bam-7218	494	18	the	the	DET
bam-7218	494	19	treatment	treatment	NOUN
bam-7218	494	20	of	of	ADP
bam-7218	494	21	chronic	chronic	ADJ
bam-7218	494	22	fibrosis	fibrosis	NOUN
bam-7218	494	23	.	.	PUNCT
bam-7218	495	1	4.4	4.4	NUM
bam-7218	495	2	gene	gene	NOUN
bam-7218	495	3	editing	editing	NOUN
bam-7218	495	4	of	of	ADP
bam-7218	495	5	dmpk	dmpk	NOUN
bam-7218	495	6	mutated	mutate	VERB
bam-7218	495	7	gene	gene	NOUN
bam-7218	495	8	in	in	ADP
bam-7218	495	9	myotonic	myotonic	ADJ
bam-7218	495	10	dystrophy	dystrophy	NOUN
bam-7218	495	11	type	type	NOUN
bam-7218	495	12	1	1	NUM
bam-7218	495	13	claudia	claudia	NOUN
bam-7218	495	14	provenzano	provenzano	NOUN
bam-7218	495	15	(	(	PUNCT
bam-7218	495	16	a	a	X
bam-7218	495	17	)	)	PUNCT
bam-7218	495	18	,	,	PUNCT
bam-7218	495	19	marisa	marisa	NOUN
bam-7218	495	20	cappella	cappella	X
bam-7218	495	21	(	(	PUNCT
bam-7218	495	22	a	a	DET
bam-7218	495	23	,	,	PUNCT
bam-7218	495	24	b	b	NOUN
bam-7218	495	25	)	)	PUNCT
bam-7218	495	26	,	,	PUNCT
bam-7218	495	27	rea	rea	PROPN
bam-7218	495	28	valaperta	valaperta	PROPN
bam-7218	495	29	(	(	PUNCT
bam-7218	495	30	c	c	NOUN
bam-7218	495	31	)	)	PUNCT
bam-7218	495	32	,	,	PUNCT
bam-7218	495	33	rosanna	rosanna	NOUN
bam-7218	495	34	cardani	cardani	X
bam-7218	495	35	(	(	PUNCT
bam-7218	495	36	d	d	NOUN
bam-7218	495	37	)	)	PUNCT
bam-7218	495	38	,	,	PUNCT
bam-7218	495	39	giovanni	giovanni	PROPN
bam-7218	495	40	meola	meola	PROPN
bam-7218	495	41	(	(	PUNCT
bam-7218	495	42	e	e	PROPN
bam-7218	495	43	,	,	PUNCT
bam-7218	495	44	f	f	PROPN
bam-7218	495	45	)	)	PUNCT
bam-7218	495	46	,	,	PUNCT
bam-7218	495	47	fabio	fabio	PROPN
bam-7218	495	48	martelli	martelli	PROPN
bam-7218	495	49	(	(	PUNCT
bam-7218	495	50	g	g	NOUN
bam-7218	495	51	)	)	PUNCT
bam-7218	495	52	,	,	PUNCT
bam-7218	495	53	beatrice	beatrice	PROPN
bam-7218	495	54	cardinali	cardinali	PROPN
bam-7218	495	55	(	(	PUNCT
bam-7218	495	56	a	a	NOUN
bam-7218	495	57	)	)	PUNCT
bam-7218	495	58	,	,	PUNCT
bam-7218	495	59	germana	germana	PROPN
bam-7218	495	60	falcone	falcone	PROPN
bam-7218	495	61	(	(	PUNCT
bam-7218	495	62	a	a	NOUN
bam-7218	495	63	)	)	PUNCT
bam-7218	495	64	(	(	PUNCT
bam-7218	495	65	a	a	PRON
bam-7218	495	66	)	)	PUNCT
bam-7218	495	67	inst	inst	NOUN
bam-7218	495	68	.	.	PUNCT
bam-7218	495	69	cell	cell	NOUN
bam-7218	495	70	biology	biology	NOUN
bam-7218	495	71	and	and	CCONJ
bam-7218	495	72	neurobiology	neurobiology	NOUN
bam-7218	495	73	,	,	PUNCT
bam-7218	495	74	national	national	PROPN
bam-7218	495	75	research	research	PROPN
bam-7218	495	76	council	council	PROPN
bam-7218	495	77	,	,	PUNCT
bam-7218	495	78	monterotondo	monterotondo	PROPN
bam-7218	495	79	;	;	PUNCT
bam-7218	495	80	(	(	PUNCT
bam-7218	495	81	b	b	X
bam-7218	495	82	)	)	PUNCT
bam-7218	495	83	dahfmo	dahfmo	NOUN
bam-7218	495	84	-	-	PUNCT
bam-7218	495	85	unit	unit	NOUN
bam-7218	495	86	of	of	ADP
bam-7218	495	87	histology	histology	NOUN
bam-7218	495	88	and	and	CCONJ
bam-7218	495	89	medical	medical	ADJ
bam-7218	495	90	embryology	embryology	PROPN
bam-7218	495	91	,	,	PUNCT
bam-7218	495	92	sapienza	sapienza	PROPN
bam-7218	495	93	university	university	PROPN
bam-7218	495	94	of	of	ADP
bam-7218	495	95	rome	rome	PROPN
bam-7218	495	96	;	;	PUNCT
bam-7218	495	97	(	(	PUNCT
bam-7218	495	98	c	c	X
bam-7218	495	99	)	)	PUNCT
bam-7218	495	100	molecular	molecular	ADJ
bam-7218	495	101	biology	biology	NOUN
bam-7218	495	102	lab	lab	NOUN
bam-7218	495	103	.	.	PUNCT
bam-7218	495	104	,	,	PUNCT
bam-7218	495	105	policlinico	policlinico	PROPN
bam-7218	495	106	san	san	PROPN
bam-7218	495	107	donato	donato	PROPN
bam-7218	495	108	-	-	PUNCT
bam-7218	495	109	irccs	irccs	NOUN
bam-7218	495	110	;	;	PUNCT
bam-7218	495	111	(	(	PUNCT
bam-7218	495	112	d	d	X
bam-7218	495	113	)	)	PUNCT
bam-7218	495	114	muscle	muscle	NOUN
bam-7218	495	115	histopathology	histopathology	NOUN
bam-7218	495	116	and	and	CCONJ
bam-7218	495	117	molecular	molecular	ADJ
bam-7218	495	118	biology	biology	NOUN
bam-7218	495	119	lab	lab	NOUN
bam-7218	495	120	.	.	PUNCT
bam-7218	495	121	,	,	PUNCT
bam-7218	495	122	policlinico	policlinico	PROPN
bam-7218	495	123	san	san	PROPN
bam-7218	495	124	donato	donato	PROPN
bam-7218	495	125	-	-	PUNCT
bam-7218	495	126	irccs	irccs	NOUN
bam-7218	495	127	;	;	PUNCT
bam-7218	495	128	(	(	PUNCT
bam-7218	495	129	e	e	NOUN
bam-7218	495	130	)	)	PUNCT
bam-7218	495	131	dept	dept	NOUN
bam-7218	495	132	of	of	ADP
bam-7218	495	133	neurology	neurology	NOUN
bam-7218	495	134	,	,	PUNCT
bam-7218	495	135	policlinico	policlinico	PROPN
bam-7218	495	136	san	san	PROPN
bam-7218	495	137	donato	donato	PROPN
bam-7218	495	138	-	-	PUNCT
bam-7218	495	139	irccs	irccs	NOUN
bam-7218	495	140	;	;	PUNCT
bam-7218	495	141	(	(	PUNCT
bam-7218	495	142	f	f	X
bam-7218	495	143	)	)	PUNCT
bam-7218	495	144	dept	dept	NOUN
bam-7218	495	145	of	of	ADP
bam-7218	495	146	biomedical	biomedical	ADJ
bam-7218	495	147	sciences	science	NOUN
bam-7218	495	148	for	for	ADP
bam-7218	495	149	health	health	NOUN
bam-7218	495	150	,	,	PUNCT
bam-7218	495	151	university	university	PROPN
bam-7218	495	152	of	of	ADP
bam-7218	495	153	milan	milan	PROPN
bam-7218	495	154	;	;	PUNCT
bam-7218	495	155	(	(	PUNCT
bam-7218	495	156	g	g	NOUN
bam-7218	495	157	)	)	PUNCT
bam-7218	495	158	molecular	molecular	ADJ
bam-7218	495	159	cardiology	cardiology	NOUN
bam-7218	495	160	lab	lab	NOUN
bam-7218	495	161	.	.	PUNCT
bam-7218	495	162	,	,	PUNCT
bam-7218	495	163	policlinico	policlinico	PROPN
bam-7218	495	164	san	san	PROPN
bam-7218	495	165	donato	donato	PROPN
bam-7218	495	166	-	-	PUNCT
bam-7218	495	167	irccs	irccs	NOUN
bam-7218	495	168	,	,	PUNCT
bam-7218	495	169	san	san	PROPN
bam-7218	495	170	donato	donato	PROPN
bam-7218	495	171	milanese	milanese	PROPN
bam-7218	495	172	,	,	PUNCT
bam-7218	495	173	italy	italy	PROPN
bam-7218	495	174	.	.	PUNCT
bam-7218	496	1	e	e	X
bam-7218	496	2	-	-	NOUN
bam-7218	496	3	mail	mail	NOUN
bam-7218	496	4	:	:	PUNCT
bam-7218	496	5	germana.falcone@cnr.it	germana.falcone@cnr.it	X
bam-7218	496	6	myotonic	myotonic	ADJ
bam-7218	496	7	dystrophy	dystrophy	NOUN
bam-7218	496	8	type	type	NOUN
bam-7218	496	9	1	1	NUM
bam-7218	496	10	(	(	PUNCT
bam-7218	496	11	dm1	dm1	NOUN
bam-7218	496	12	)	)	PUNCT
bam-7218	496	13	is	be	AUX
bam-7218	496	14	the	the	DET
bam-7218	496	15	most	most	ADV
bam-7218	496	16	common	common	ADJ
bam-7218	496	17	adult	adult	NOUN
bam-7218	496	18	-	-	PUNCT
bam-7218	496	19	onset	onset	VERB
bam-7218	496	20	muscular	muscular	ADJ
bam-7218	496	21	dystrophy	dystrophy	NOUN
bam-7218	496	22	,	,	PUNCT
bam-7218	496	23	caused	cause	VERB
bam-7218	496	24	by	by	ADP
bam-7218	496	25	a	a	DET
bam-7218	496	26	(	(	PUNCT
bam-7218	496	27	ctg)n	ctg)n	NOUN
bam-7218	496	28	expansion	expansion	NOUN
bam-7218	496	29	within	within	ADP
bam-7218	496	30	the	the	DET
bam-7218	496	31	3	3	NUM
bam-7218	496	32	’	'	PUNCT
bam-7218	496	33	untranslated	untranslated	ADJ
bam-7218	496	34	region	region	NOUN
bam-7218	496	35	of	of	ADP
bam-7218	496	36	the	the	DET
bam-7218	496	37	dmpk	dmpk	NOUN
bam-7218	496	38	gene	gene	NOUN
bam-7218	496	39	and	and	CCONJ
bam-7218	496	40	characterized	characterize	VERB
bam-7218	496	41	by	by	ADP
bam-7218	496	42	progressive	progressive	ADJ
bam-7218	496	43	myopathy	myopathy	ADJ
bam-7218	496	44	,	,	PUNCT
bam-7218	496	45	myotonia	myotonia	NOUN
bam-7218	496	46	and	and	CCONJ
bam-7218	496	47	multiorgan	multiorgan	PROPN
bam-7218	496	48	involvement	involvement	NOUN
bam-7218	496	49	.	.	PUNCT
bam-7218	497	1	expression	expression	NOUN
bam-7218	497	2	of	of	ADP
bam-7218	497	3	the	the	DET
bam-7218	497	4	mutated	mutate	VERB
bam-7218	497	5	gene	gene	NOUN
bam-7218	497	6	results	result	NOUN
bam-7218	497	7	in	in	ADP
bam-7218	497	8	production	production	NOUN
bam-7218	497	9	of	of	ADP
bam-7218	497	10	toxic	toxic	ADJ
bam-7218	497	11	transcripts	transcript	NOUN
bam-7218	497	12	that	that	PRON
bam-7218	497	13	aggregate	aggregate	VERB
bam-7218	497	14	as	as	ADP
bam-7218	497	15	nuclear	nuclear	ADJ
bam-7218	497	16	foci	focus	NOUN
bam-7218	497	17	where	where	SCONJ
bam-7218	497	18	rna	rna	NOUN
bam-7218	497	19	-	-	PUNCT
bam-7218	497	20	binding	bind	VERB
bam-7218	497	21	proteins	protein	NOUN
bam-7218	497	22	are	be	AUX
bam-7218	497	23	sequestered	sequester	VERB
bam-7218	497	24	,	,	PUNCT
bam-7218	497	25	resulting	result	VERB
bam-7218	497	26	in	in	ADP
bam-7218	497	27	missplicing	missplice	VERB
bam-7218	497	28	of	of	ADP
bam-7218	497	29	several	several	ADJ
bam-7218	497	30	transcripts	transcript	NOUN
bam-7218	497	31	,	,	PUNCT
bam-7218	497	32	defective	defective	ADJ
bam-7218	497	33	translation	translation	NOUN
bam-7218	497	34	and	and	CCONJ
bam-7218	497	35	microrna	microrna	PROPN
bam-7218	497	36	dysregulation	dysregulation	PROPN
bam-7218	497	37	.	.	PUNCT
bam-7218	498	1	no	no	DET
bam-7218	498	2	effective	effective	ADJ
bam-7218	498	3	therapy	therapy	NOUN
bam-7218	498	4	is	be	AUX
bam-7218	498	5	yet	yet	ADV
bam-7218	498	6	available	available	ADJ
bam-7218	498	7	for	for	ADP
bam-7218	498	8	treatment	treatment	NOUN
bam-7218	498	9	of	of	ADP
bam-7218	498	10	the	the	DET
bam-7218	498	11	disease	disease	NOUN
bam-7218	498	12	.	.	PUNCT
bam-7218	499	1	in	in	ADP
bam-7218	499	2	this	this	DET
bam-7218	499	3	study	study	NOUN
bam-7218	499	4	we	we	PRON
bam-7218	499	5	exploited	exploit	VERB
bam-7218	499	6	the	the	DET
bam-7218	499	7	crispr	crispr	ADJ
bam-7218	499	8	/	/	SYM
bam-7218	499	9	cas9	cas9	NOUN
bam-7218	499	10	gene	gene	NOUN
bam-7218	499	11	editing	edit	VERB
bam-7218	499	12	strategy	strategy	NOUN
bam-7218	499	13	to	to	PART
bam-7218	499	14	remove	remove	VERB
bam-7218	499	15	the	the	DET
bam-7218	499	16	pathogenetic	pathogenetic	ADJ
bam-7218	499	17	repeat	repeat	NOUN
bam-7218	499	18	expansions	expansion	NOUN
bam-7218	499	19	for	for	ADP
bam-7218	499	20	future	future	ADJ
bam-7218	499	21	therapeutic	therapeutic	ADJ
bam-7218	499	22	use	use	NOUN
bam-7218	499	23	.	.	PUNCT
bam-7218	500	1	to	to	ADP
bam-7218	500	2	this	this	DET
bam-7218	500	3	aim	aim	NOUN
bam-7218	500	4	we	we	PRON
bam-7218	500	5	generated	generate	VERB
bam-7218	500	6	dm1	dm1	PROPN
bam-7218	500	7	myogenic	myogenic	ADJ
bam-7218	500	8	cell	cell	NOUN
bam-7218	500	9	models	model	NOUN
bam-7218	500	10	from	from	ADP
bam-7218	500	11	dm1	dm1	PROPN
bam-7218	500	12	patient	patient	NOUN
bam-7218	500	13	-	-	PUNCT
bam-7218	500	14	derived	derive	VERB
bam-7218	500	15	fibroblasts	fibroblast	NOUN
bam-7218	500	16	,	,	PUNCT
bam-7218	500	17	exhibiting	exhibit	VERB
bam-7218	500	18	typical	typical	ADJ
bam-7218	500	19	disease	disease	NOUN
bam-7218	500	20	-	-	PUNCT
bam-7218	500	21	associated	associate	VERB
bam-7218	500	22	alterations	alteration	NOUN
bam-7218	500	23	.	.	PUNCT
bam-7218	501	1	we	we	PRON
bam-7218	501	2	will	will	AUX
bam-7218	501	3	show	show	VERB
bam-7218	501	4	that	that	SCONJ
bam-7218	501	5	by	by	ADP
bam-7218	501	6	using	use	VERB
bam-7218	501	7	the	the	DET
bam-7218	501	8	crispr	crispr	NOUN
bam-7218	501	9	/	/	SYM
bam-7218	501	10	cas9	cas9	NOUN
bam-7218	501	11	and	and	CCONJ
bam-7218	501	12	nhej	nhej	ADJ
bam-7218	501	13	gene	gene	NOUN
bam-7218	501	14	-	-	PUNCT
bam-7218	501	15	editing	edit	VERB
bam-7218	501	16	system	system	NOUN
bam-7218	501	17	ctg	ctg	NOUN
bam-7218	501	18	expansions	expansion	NOUN
bam-7218	501	19	can	can	AUX
bam-7218	501	20	be	be	AUX
bam-7218	501	21	removed	remove	VERB
bam-7218	501	22	permanently	permanently	ADV
bam-7218	501	23	from	from	ADP
bam-7218	501	24	dmpk	dmpk	NOUN
bam-7218	501	25	gene	gene	NOUN
bam-7218	501	26	,	,	PUNCT
bam-7218	501	27	resulting	result	VERB
bam-7218	501	28	in	in	ADP
bam-7218	501	29	phenotypic	phenotypic	ADJ
bam-7218	501	30	reversion	reversion	NOUN
bam-7218	501	31	of	of	ADP
bam-7218	501	32	edited	edited	ADJ
bam-7218	501	33	cells	cell	NOUN
bam-7218	501	34	.	.	PUNCT
bam-7218	502	1	4.5	4.5	NUM
bam-7218	502	2	hdac4	hdac4	NOUN
bam-7218	502	3	preserves	preserve	VERB
bam-7218	502	4	skeletal	skeletal	ADJ
bam-7218	502	5	muscle	muscle	NOUN
bam-7218	502	6	structure	structure	NOUN
bam-7218	502	7	following	follow	VERB
bam-7218	502	8	long	long	ADJ
bam-7218	502	9	-	-	PUNCT
bam-7218	502	10	term	term	NOUN
bam-7218	502	11	denervation	denervation	NOUN
bam-7218	502	12	mediating	mediate	VERB
bam-7218	502	13	the	the	DET
bam-7218	502	14	activation	activation	NOUN
bam-7218	502	15	of	of	ADP
bam-7218	502	16	catabolic	catabolic	ADJ
bam-7218	502	17	pathways	pathway	NOUN
bam-7218	502	18	eva	eva	PROPN
bam-7218	502	19	pigna	pigna	PROPN
bam-7218	502	20	,	,	PUNCT
bam-7218	502	21	emanuela	emanuela	PROPN
bam-7218	502	22	greco	greco	PROPN
bam-7218	502	23	,	,	PUNCT
bam-7218	502	24	elena	elena	PROPN
bam-7218	502	25	simonazzi	simonazzi	PROPN
bam-7218	502	26	,	,	PUNCT
bam-7218	502	27	sergio	sergio	PROPN
bam-7218	502	28	adamo	adamo	PROPN
bam-7218	502	29	,	,	PUNCT
bam-7218	502	30	viviana	viviana	PROPN
bam-7218	502	31	moresi	moresi	PROPN
bam-7218	502	32	dahfmo	dahfmo	PROPN
bam-7218	502	33	unit	unit	NOUN
bam-7218	502	34	of	of	ADP
bam-7218	502	35	histology	histology	NOUN
bam-7218	502	36	and	and	CCONJ
bam-7218	502	37	medical	medical	ADJ
bam-7218	502	38	embryology	embryology	PROPN
bam-7218	502	39	,	,	PUNCT
bam-7218	502	40	interuniversity	interuniversity	NOUN
bam-7218	502	41	institute	institute	PROPN
bam-7218	502	42	of	of	ADP
bam-7218	502	43	myology	myology	NOUN
bam-7218	502	44	,	,	PUNCT
bam-7218	502	45	sapienza	sapienza	PROPN
bam-7218	502	46	university	university	PROPN
bam-7218	502	47	of	of	ADP
bam-7218	502	48	rome	rome	PROPN
bam-7218	502	49	,	,	PUNCT
bam-7218	502	50	italy	italy	PROPN
bam-7218	502	51	.	.	PUNCT
bam-7218	503	1	e	e	X
bam-7218	503	2	-	-	NOUN
bam-7218	503	3	mail	mail	NOUN
bam-7218	503	4	:	:	PUNCT
bam-7218	503	5	eva.pigna@uniroma1.it	eva.pigna@uniroma1.it	NOUN
bam-7218	503	6	loss	loss	NOUN
bam-7218	503	7	of	of	ADP
bam-7218	503	8	muscle	muscle	NOUN
bam-7218	503	9	innervation	innervation	NOUN
bam-7218	503	10	occurs	occur	VERB
bam-7218	503	11	in	in	ADP
bam-7218	503	12	several	several	ADJ
bam-7218	503	13	pathological	pathological	ADJ
bam-7218	503	14	conditions	condition	NOUN
bam-7218	503	15	and	and	CCONJ
bam-7218	503	16	mainly	mainly	ADV
bam-7218	503	17	depends	depend	VERB
bam-7218	503	18	on	on	ADP
bam-7218	503	19	the	the	DET
bam-7218	503	20	imbalance	imbalance	NOUN
bam-7218	503	21	between	between	ADP
bam-7218	503	22	protein	protein	NOUN
bam-7218	503	23	synthesis	synthesis	NOUN
bam-7218	503	24	and	and	CCONJ
bam-7218	503	25	degradation	degradation	NOUN
bam-7218	503	26	(	(	PUNCT
bam-7218	503	27	1,2,3	1,2,3	NUM
bam-7218	503	28	)	)	PUNCT
bam-7218	503	29	.	.	PUNCT
bam-7218	504	1	the	the	DET
bam-7218	504	2	ubiquitin	ubiquitin	ADJ
bam-7218	504	3	proteasome	proteasome	NOUN
bam-7218	504	4	system	system	NOUN
bam-7218	504	5	(	(	PUNCT
bam-7218	504	6	ups	up	NOUN
bam-7218	504	7	)	)	PUNCT
bam-7218	504	8	and	and	CCONJ
bam-7218	504	9	autophagy	autophagy	NOUN
bam-7218	504	10	are	be	AUX
bam-7218	504	11	the	the	DET
bam-7218	504	12	two	two	NUM
bam-7218	504	13	main	main	ADJ
bam-7218	504	14	proteolytic	proteolytic	ADJ
bam-7218	504	15	pathways	pathway	NOUN
bam-7218	504	16	in	in	ADP
bam-7218	504	17	skeletal	skeletal	ADJ
bam-7218	504	18	muscle	muscle	NOUN
bam-7218	504	19	,	,	PUNCT
bam-7218	504	20	which	which	PRON
bam-7218	504	21	are	be	AUX
bam-7218	504	22	activated	activate	VERB
bam-7218	504	23	upon	upon	SCONJ
bam-7218	504	24	denervation	denervation	NOUN
bam-7218	504	25	and	and	CCONJ
bam-7218	504	26	contribute	contribute	VERB
bam-7218	504	27	to	to	ADP
bam-7218	504	28	the	the	DET
bam-7218	504	29	maintenance	maintenance	NOUN
bam-7218	504	30	of	of	ADP
bam-7218	504	31	muscle	muscle	NOUN
bam-7218	504	32	homeostasis	homeostasis	NOUN
bam-7218	504	33	(	(	PUNCT
bam-7218	504	34	4,5	4,5	NUM
bam-7218	504	35	)	)	PUNCT
bam-7218	504	36	.	.	PUNCT
bam-7218	505	1	histone	histone	NOUN
bam-7218	505	2	deacetylase	deacetylase	VERB
bam-7218	505	3	4	4	NUM
bam-7218	505	4	(	(	PUNCT
bam-7218	505	5	hdac4	hdac4	PROPN
bam-7218	505	6	)	)	PUNCT
bam-7218	505	7	is	be	AUX
bam-7218	505	8	an	an	DET
bam-7218	505	9	epigenetic	epigenetic	ADJ
bam-7218	505	10	factor	factor	NOUN
bam-7218	505	11	that	that	PRON
bam-7218	505	12	mediates	mediate	VERB
bam-7218	505	13	skeletal	skeletal	ADJ
bam-7218	505	14	muscle	muscle	NOUN
bam-7218	505	15	response	response	NOUN
bam-7218	505	16	following	follow	VERB
bam-7218	505	17	denervation	denervation	NOUN
bam-7218	505	18	.	.	PUNCT
bam-7218	506	1	under	under	ADP
bam-7218	506	2	this	this	DET
bam-7218	506	3	condition	condition	NOUN
bam-7218	506	4	,	,	PUNCT
bam-7218	506	5	hdac4	hdac4	NOUN
bam-7218	506	6	mediates	mediate	VERB
bam-7218	506	7	skeletal	skeletal	ADJ
bam-7218	506	8	muscle	muscle	NOUN
bam-7218	506	9	atrophy	atrophy	NOUN
bam-7218	506	10	(	(	PUNCT
bam-7218	506	11	6,7	6,7	NUM
bam-7218	506	12	)	)	PUNCT
bam-7218	506	13	,	,	PUNCT
bam-7218	506	14	suggesting	suggest	VERB
bam-7218	506	15	the	the	DET
bam-7218	506	16	use	use	NOUN
bam-7218	506	17	of	of	ADP
bam-7218	506	18	hdac4	hdac4	NOUN
bam-7218	506	19	inhibitors	inhibitor	NOUN
bam-7218	506	20	as	as	ADP
bam-7218	506	21	pharmaceutical	pharmaceutical	ADJ
bam-7218	506	22	treatment	treatment	NOUN
bam-7218	506	23	for	for	ADP
bam-7218	506	24	neurogenic	neurogenic	ADJ
bam-7218	506	25	muscle	muscle	NOUN
bam-7218	506	26	atrophy	atrophy	NOUN
bam-7218	506	27	.	.	PUNCT
bam-7218	507	1	accordingly	accordingly	ADV
bam-7218	507	2	,	,	PUNCT
bam-7218	507	3	mice	mouse	NOUN
bam-7218	507	4	lacking	lack	VERB
bam-7218	507	5	hdac4	hdac4	NOUN
bam-7218	507	6	in	in	ADP
bam-7218	507	7	skeletal	skeletal	ADJ
bam-7218	507	8	muscle	muscle	NOUN
bam-7218	507	9	are	be	AUX
bam-7218	507	10	resistant	resistant	ADJ
bam-7218	507	11	to	to	ADP
bam-7218	507	12	neurogenic	neurogenic	ADJ
bam-7218	507	13	muscle	muscle	NOUN
bam-7218	507	14	atrophy	atrophy	NOUN
bam-7218	507	15	.	.	PUNCT
bam-7218	508	1	however	however	ADV
bam-7218	508	2	,	,	PUNCT
bam-7218	508	3	the	the	DET
bam-7218	508	4	effects	effect	NOUN
bam-7218	508	5	of	of	ADP
bam-7218	508	6	hdac4	hdac4	NOUN
bam-7218	508	7	inhibition	inhibition	NOUN
bam-7218	508	8	in	in	ADP
bam-7218	508	9	a	a	DET
bam-7218	508	10	condition	condition	NOUN
bam-7218	508	11	of	of	ADP
bam-7218	508	12	long	long	ADJ
bam-7218	508	13	-	-	PUNCT
bam-7218	508	14	term	term	NOUN
bam-7218	508	15	denervation	denervation	NOUN
bam-7218	508	16	have	have	AUX
bam-7218	508	17	not	not	PART
bam-7218	508	18	been	be	AUX
bam-7218	508	19	clarified	clarify	VERB
bam-7218	508	20	yet	yet	ADV
bam-7218	508	21	.	.	PUNCT
bam-7218	509	1	to	to	PART
bam-7218	509	2	investigate	investigate	VERB
bam-7218	509	3	the	the	DET
bam-7218	509	4	role	role	NOUN
bam-7218	509	5	of	of	ADP
bam-7218	509	6	hdac4	hdac4	NOUN
bam-7218	509	7	in	in	ADP
bam-7218	509	8	skeletal	skeletal	ADJ
bam-7218	509	9	muscle	muscle	NOUN
bam-7218	509	10	following	follow	VERB
bam-7218	509	11	long	long	ADJ
bam-7218	509	12	-	-	PUNCT
bam-7218	509	13	term	term	NOUN
bam-7218	509	14	denervation	denervation	NOUN
bam-7218	509	15	with	with	ADP
bam-7218	509	16	a	a	DET
bam-7218	509	17	genetic	genetic	ADJ
bam-7218	509	18	approach	approach	NOUN
bam-7218	509	19	,	,	PUNCT
bam-7218	509	20	we	we	PRON
bam-7218	509	21	analyzed	analyze	VERB
bam-7218	509	22	mutant	mutant	ADJ
bam-7218	509	23	mice	mouse	NOUN
bam-7218	509	24	with	with	ADP
bam-7218	509	25	a	a	DET
bam-7218	509	26	tissue	tissue	NOUN
bam-7218	509	27	-	-	PUNCT
bam-7218	509	28	specific	specific	ADJ
bam-7218	509	29	deletion	deletion	NOUN
bam-7218	509	30	of	of	ADP
bam-7218	509	31	hdac4	hdac4	NOUN
bam-7218	509	32	(	(	PUNCT
bam-7218	509	33	hdac4mko	hdac4mko	INTJ
bam-7218	509	34	mice	mouse	NOUN
bam-7218	509	35	)	)	PUNCT
bam-7218	509	36	.	.	PUNCT
bam-7218	510	1	strikingly	strikingly	ADV
bam-7218	510	2	,	,	PUNCT
bam-7218	510	3	while	while	SCONJ
bam-7218	510	4	hdac4mko	hdac4mko	ADP
bam-7218	510	5	muscles	muscle	NOUN
bam-7218	510	6	were	be	AUX
bam-7218	510	7	resistant	resistant	ADJ
bam-7218	510	8	to	to	ADP
bam-7218	510	9	neurogenic	neurogenic	ADJ
bam-7218	510	10	muscle	muscle	NOUN
bam-7218	510	11	atrophy	atrophy	NOUN
bam-7218	510	12	two	two	NUM
bam-7218	510	13	weeks	week	NOUN
bam-7218	510	14	following	follow	VERB
bam-7218	510	15	denervation	denervation	NOUN
bam-7218	510	16	,	,	PUNCT
bam-7218	510	17	muscles	muscle	NOUN
bam-7218	510	18	degenerated	degenerated	ADJ
bam-7218	510	19	following	follow	VERB
bam-7218	510	20	4	4	NUM
bam-7218	510	21	weeks	week	NOUN
bam-7218	510	22	of	of	ADP
bam-7218	510	23	denervation	denervation	NOUN
bam-7218	510	24	.	.	PUNCT
bam-7218	511	1	we	we	PRON
bam-7218	511	2	demonstrate	demonstrate	VERB
bam-7218	511	3	that	that	SCONJ
bam-7218	511	4	,	,	PUNCT
bam-7218	511	5	upon	upon	SCONJ
bam-7218	511	6	denervation	denervation	NOUN
bam-7218	511	7	,	,	PUNCT
bam-7218	511	8	hdac4	hdac4	NOUN
bam-7218	511	9	mediates	mediate	VERB
bam-7218	511	10	both	both	CCONJ
bam-7218	511	11	the	the	DET
bam-7218	511	12	ups	up	NOUN
bam-7218	511	13	and	and	CCONJ
bam-7218	511	14	the	the	DET
bam-7218	511	15	autophagic	autophagic	PROPN
bam-7218	511	16	flux	flux	NOUN
bam-7218	511	17	,	,	PUNCT
bam-7218	511	18	which	which	PRON
bam-7218	511	19	resulted	result	VERB
bam-7218	511	20	crucial	crucial	ADJ
bam-7218	511	21	for	for	ADP
bam-7218	511	22	maintaining	maintain	VERB
bam-7218	511	23	muscle	muscle	NOUN
bam-7218	511	24	homeostasis	homeostasis	NOUN
bam-7218	511	25	.	.	PUNCT
bam-7218	512	1	indeed	indeed	ADV
bam-7218	512	2	,	,	PUNCT
bam-7218	512	3	by	by	ADP
bam-7218	512	4	triggering	trigger	VERB
bam-7218	512	5	either	either	CCONJ
bam-7218	512	6	one	one	NUM
bam-7218	512	7	of	of	ADP
bam-7218	512	8	these	these	DET
bam-7218	512	9	two	two	NUM
bam-7218	512	10	catabolic	catabolic	ADJ
bam-7218	512	11	pathways	pathway	NOUN
bam-7218	512	12	in	in	ADP
bam-7218	512	13	hdac4mko	hdac4mko	DET
bam-7218	512	14	mice	mouse	NOUN
bam-7218	512	15	,	,	PUNCT
bam-7218	512	16	muscle	muscle	NOUN
bam-7218	512	17	degeneration	degeneration	NOUN
bam-7218	512	18	was	be	AUX
bam-7218	512	19	significantly	significantly	ADV
bam-7218	512	20	reduced	reduce	VERB
bam-7218	512	21	4	4	NUM
bam-7218	512	22	weeks	week	NOUN
bam-7218	512	23	after	after	ADP
bam-7218	512	24	denervation	denervation	NOUN
bam-7218	512	25	.	.	PUNCT
bam-7218	513	1	these	these	DET
bam-7218	513	2	findings	finding	NOUN
bam-7218	513	3	reveale	reveale	NOUN
bam-7218	513	4	that	that	SCONJ
bam-7218	513	5	hdac4	hdac4	NOUN
bam-7218	513	6	mediates	mediate	VERB
bam-7218	513	7	the	the	DET
bam-7218	513	8	activation	activation	NOUN
bam-7218	513	9	of	of	ADP
bam-7218	513	10	the	the	DET
bam-7218	513	11	catabolic	catabolic	ADJ
bam-7218	513	12	pathways	pathway	NOUN
bam-7218	513	13	in	in	ADP
bam-7218	513	14	skeletal	skeletal	ADJ
bam-7218	513	15	muscle	muscle	NOUN
bam-7218	513	16	and	and	CCONJ
bam-7218	513	17	that	that	SCONJ
bam-7218	513	18	inhibition	inhibition	NOUN
bam-7218	513	19	of	of	ADP
bam-7218	513	20	hdac4	hdac4	NOUN
bam-7218	513	21	,	,	PUNCT
bam-7218	513	22	in	in	ADP
bam-7218	513	23	a	a	DET
bam-7218	513	24	mailto:germana.falcone@cnr.it	mailto:germana.falcone@cnr.it	NOUN
bam-7218	513	25	mailto:eva.pigna@uniroma1.it	mailto:eva.pigna@uniroma1.it	NOUN
bam-7218	513	26	14	14	NUM
bam-7218	513	27	th	th	NUM
bam-7218	513	28	iiim	iiim	NOUN
bam-7218	513	29	meeting	meeting	NOUN
bam-7218	513	30	,	,	PUNCT
bam-7218	513	31	assisi	assisi	PROPN
bam-7218	513	32	,	,	PUNCT
bam-7218	513	33	italy	italy	PROPN
bam-7218	513	34	october	october	PROPN
bam-7218	513	35	12	12	NUM
bam-7218	513	36	-	-	SYM
bam-7218	513	37	15	15	NUM
bam-7218	513	38	2017	2017	NUM
bam-7218	513	39	eur	eur	PROPN
bam-7218	513	40	j	j	PROPN
bam-7218	513	41	transl	transl	PROPN
bam-7218	513	42	myol	myol	ADV
bam-7218	513	43	27	27	NUM
bam-7218	513	44	(	(	PUNCT
bam-7218	513	45	4	4	NUM
bam-7218	513	46	):	):	SYM
bam-7218	513	47	185	185	NUM
bam-7218	513	48	-	-	SYM
bam-7218	513	49	224	224	NUM
bam-7218	513	50	200	200	NUM
bam-7218	513	51	condition	condition	NOUN
bam-7218	513	52	of	of	ADP
bam-7218	513	53	long	long	ADJ
bam-7218	513	54	-	-	PUNCT
bam-7218	513	55	term	term	NOUN
bam-7218	513	56	denervation	denervation	NOUN
bam-7218	513	57	,	,	PUNCT
bam-7218	513	58	leads	lead	VERB
bam-7218	513	59	to	to	ADP
bam-7218	513	60	skeletal	skeletal	ADJ
bam-7218	513	61	muscle	muscle	NOUN
bam-7218	513	62	degeneration	degeneration	NOUN
bam-7218	513	63	.	.	PUNCT
bam-7218	514	1	references	reference	NOUN
bam-7218	514	2	:	:	PUNCT
bam-7218	514	3	1	1	X
bam-7218	514	4	.	.	PUNCT
bam-7218	514	5	j.	j.	PROPN
bam-7218	514	6	biol	biol	PROPN
bam-7218	514	7	.	.	PUNCT
bam-7218	515	1	chem	chem	PROPN
bam-7218	515	2	.	.	PUNCT
bam-7218	516	1	282	282	NUM
bam-7218	516	2	,	,	PUNCT
bam-7218	516	3	7087–7097	7087–7097	NUM
bam-7218	516	4	.	.	NOUN
bam-7218	516	5	2	2	NUM
bam-7218	516	6	.	.	NOUN
bam-7218	516	7	trends	trend	NOUN
bam-7218	516	8	mol	mol	PROPN
bam-7218	516	9	.	.	PROPN
bam-7218	516	10	med	med	PROPN
bam-7218	516	11	.	.	PROPN
bam-7218	517	1	9	9	NUM
bam-7218	517	2	,	,	PUNCT
bam-7218	517	3	344–350	344–350	NUM
bam-7218	517	4	.	.	PUNCT
bam-7218	518	1	3	3	X
bam-7218	518	2	.	.	X
bam-7218	518	3	cell	cell	NOUN
bam-7218	518	4	117	117	NUM
bam-7218	518	5	,	,	PUNCT
bam-7218	518	6	399–412	399–412	NUM
bam-7218	518	7	4	4	NUM
bam-7218	518	8	.	.	PUNCT
bam-7218	519	1	the	the	DET
bam-7218	519	2	faseb	faseb	PROPN
bam-7218	519	3	journal	journal	PROPN
bam-7218	519	4	vol	vol	NOUN
bam-7218	519	5	.	.	PROPN
bam-7218	520	1	26	26	NUM
bam-7218	520	2	no	no	NOUN
bam-7218	520	3	.	.	NOUN
bam-7218	520	4	7	7	NUM
bam-7218	520	5	2986	2986	NUM
bam-7218	520	6	-	-	SYM
bam-7218	520	7	2999	2999	NUM
bam-7218	520	8	5	5	NUM
bam-7218	520	9	.	.	PUNCT
bam-7218	520	10	cell	cell	NOUN
bam-7218	520	11	metab	metab	NOUN
bam-7218	520	12	.	.	PUNCT
bam-7218	521	1	2009	2009	NUM
bam-7218	521	2	dec;10(6):50715	dec;10(6):50715	NOUN
bam-7218	521	3	6	6	NUM
bam-7218	521	4	)	)	PUNCT
bam-7218	521	5	cell	cell	NOUN
bam-7218	521	6	.	.	PUNCT
bam-7218	522	1	2010	2010	NUM
bam-7218	522	2	oct	oct	NOUN
bam-7218	522	3	1;143(1):35	1;143(1):35	PROPN
bam-7218	522	4	-	-	SYM
bam-7218	522	5	45	45	NUM
bam-7218	522	6	.	.	PUNCT
bam-7218	522	7	4.6	4.6	NUM
bam-7218	522	8	an	an	DET
bam-7218	522	9	in	in	ADP
bam-7218	522	10	vitro	vitro	X
bam-7218	522	11	model	model	NOUN
bam-7218	522	12	of	of	ADP
bam-7218	522	13	fshd	fshd	ADJ
bam-7218	522	14	based	base	VERB
bam-7218	522	15	on	on	ADP
bam-7218	522	16	human	human	ADJ
bam-7218	522	17	pluripotent	pluripotent	NOUN
bam-7218	522	18	stem	stem	NOUN
bam-7218	522	19	cell	cell	NOUN
bam-7218	522	20	-	-	PUNCT
bam-7218	522	21	derived	derive	VERB
bam-7218	522	22	skeletal	skeletal	ADJ
bam-7218	522	23	myotubes	myotube	NOUN
bam-7218	522	24	and	and	CCONJ
bam-7218	522	25	its	its	PRON
bam-7218	522	26	application	application	NOUN
bam-7218	522	27	in	in	ADP
bam-7218	522	28	drug	drug	NOUN
bam-7218	522	29	discovery	discovery	PROPN
bam-7218	522	30	amanda	amanda	PROPN
bam-7218	522	31	marie	marie	PROPN
bam-7218	522	32	rickard	rickard	PROPN
bam-7218	522	33	,	,	PUNCT
bam-7218	522	34	jamshid	jamshid	PROPN
bam-7218	522	35	arjomand	arjomand	PROPN
bam-7218	522	36	,	,	PUNCT
bam-7218	522	37	alex	alex	PROPN
bam-7218	522	38	kiselyov	kiselyov	PROPN
bam-7218	522	39	,	,	PUNCT
bam-7218	522	40	uli	uli	PROPN
bam-7218	522	41	schmidt	schmidt	PROPN
bam-7218	522	42	genea	genea	PROPN
bam-7218	522	43	biocells	biocell	NOUN
bam-7218	522	44	,	,	PUNCT
bam-7218	522	45	san	san	PROPN
bam-7218	522	46	diego	diego	PROPN
bam-7218	522	47	,	,	PUNCT
bam-7218	522	48	ca	ca	PROPN
bam-7218	522	49	,	,	PUNCT
bam-7218	522	50	usa	usa	PROPN
bam-7218	522	51	.	.	PROPN
bam-7218	522	52	e	e	X
bam-7218	522	53	-	-	NOUN
bam-7218	522	54	mail	mail	NOUN
bam-7218	522	55	:	:	PUNCT
bam-7218	522	56	uli.schmidt@geneabiocells.com	uli.schmidt@geneabiocells.com	PROPN
bam-7218	522	57	facioscapulohumeral	facioscapulohumeral	ADJ
bam-7218	522	58	muscular	muscular	ADJ
bam-7218	522	59	dystrophy	dystrophy	NOUN
bam-7218	522	60	(	(	PUNCT
bam-7218	522	61	fshd	fshd	ADJ
bam-7218	522	62	)	)	PUNCT
bam-7218	522	63	is	be	AUX
bam-7218	522	64	caused	cause	VERB
bam-7218	522	65	by	by	ADP
bam-7218	522	66	a	a	DET
bam-7218	522	67	contraction	contraction	NOUN
bam-7218	522	68	of	of	ADP
bam-7218	522	69	the	the	DET
bam-7218	522	70	d4z4	d4z4	PROPN
bam-7218	522	71	macrosatellite	macrosatellite	PROPN
bam-7218	522	72	repeat	repeat	NOUN
bam-7218	522	73	on	on	ADP
bam-7218	522	74	the	the	DET
bam-7218	522	75	subtelomere	subtelomere	NOUN
bam-7218	522	76	of	of	ADP
bam-7218	522	77	chromosome	chromosome	NOUN
bam-7218	522	78	4	4	NUM
bam-7218	522	79	.	.	PUNCT
bam-7218	523	1	this	this	DET
bam-7218	523	2	genetic	genetic	ADJ
bam-7218	523	3	lesion	lesion	NOUN
bam-7218	523	4	results	result	VERB
bam-7218	523	5	in	in	ADP
bam-7218	523	6	epigenetic	epigenetic	ADJ
bam-7218	523	7	derepression	derepression	NOUN
bam-7218	523	8	and	and	CCONJ
bam-7218	523	9	aberrant	aberrant	ADJ
bam-7218	523	10	transcription	transcription	NOUN
bam-7218	523	11	of	of	ADP
bam-7218	523	12	the	the	DET
bam-7218	523	13	pathogenic	pathogenic	ADJ
bam-7218	523	14	double	double	ADJ
bam-7218	523	15	homeobox	homeobox	NOUN
bam-7218	523	16	domain	domain	NOUN
bam-7218	523	17	-	-	PUNCT
bam-7218	523	18	containing	contain	VERB
bam-7218	523	19	protein	protein	NOUN
bam-7218	523	20	4	4	NUM
bam-7218	523	21	(	(	PUNCT
bam-7218	523	22	dux4	dux4	NOUN
bam-7218	523	23	)	)	PUNCT
bam-7218	523	24	gene	gene	NOUN
bam-7218	523	25	.	.	PUNCT
bam-7218	524	1	understanding	understand	VERB
bam-7218	524	2	the	the	DET
bam-7218	524	3	pathogenesis	pathogenesis	NOUN
bam-7218	524	4	of	of	ADP
bam-7218	524	5	fshd	fshd	ADJ
bam-7218	524	6	and	and	CCONJ
bam-7218	524	7	development	development	NOUN
bam-7218	524	8	of	of	ADP
bam-7218	524	9	a	a	DET
bam-7218	524	10	dux4	dux4	NOUN
bam-7218	524	11	-	-	PUNCT
bam-7218	524	12	silencing	silence	VERB
bam-7218	524	13	therapy	therapy	NOUN
bam-7218	524	14	will	will	AUX
bam-7218	524	15	require	require	VERB
bam-7218	524	16	characterization	characterization	NOUN
bam-7218	524	17	of	of	ADP
bam-7218	524	18	the	the	DET
bam-7218	524	19	molecular	molecular	ADJ
bam-7218	524	20	players	player	NOUN
bam-7218	524	21	that	that	PRON
bam-7218	524	22	direct	direct	ADJ
bam-7218	524	23	transcriptional	transcriptional	ADJ
bam-7218	524	24	activation	activation	NOUN
bam-7218	524	25	of	of	ADP
bam-7218	524	26	the	the	DET
bam-7218	524	27	d4z4	d4z4	NOUN
bam-7218	524	28	locus	locus	NOUN
bam-7218	524	29	.	.	PUNCT
bam-7218	525	1	we	we	PRON
bam-7218	525	2	developed	develop	VERB
bam-7218	525	3	one	one	NUM
bam-7218	525	4	of	of	ADP
bam-7218	525	5	the	the	DET
bam-7218	525	6	largest	large	ADJ
bam-7218	525	7	banks	bank	NOUN
bam-7218	525	8	of	of	ADP
bam-7218	525	9	disease	disease	NOUN
bam-7218	525	10	-	-	PUNCT
bam-7218	525	11	affected	affect	VERB
bam-7218	525	12	human	human	ADJ
bam-7218	525	13	embryonic	embryonic	ADJ
bam-7218	525	14	stem	stem	NOUN
bam-7218	525	15	cells	cell	NOUN
bam-7218	525	16	(	(	PUNCT
bam-7218	525	17	hescs	hesc	NOUN
bam-7218	525	18	)	)	PUNCT
bam-7218	525	19	,	,	PUNCT
bam-7218	525	20	including	include	VERB
bam-7218	525	21	fshdaffected	fshdaffected	ADJ
bam-7218	525	22	cell	cell	NOUN
bam-7218	525	23	lines	line	NOUN
bam-7218	525	24	.	.	PUNCT
bam-7218	526	1	in	in	ADP
bam-7218	526	2	addition	addition	NOUN
bam-7218	526	3	,	,	PUNCT
bam-7218	526	4	we	we	PRON
bam-7218	526	5	developed	develop	VERB
bam-7218	526	6	and	and	CCONJ
bam-7218	526	7	published	publish	VERB
bam-7218	526	8	a	a	DET
bam-7218	526	9	fast	fast	ADJ
bam-7218	526	10	,	,	PUNCT
bam-7218	526	11	robust	robust	ADJ
bam-7218	526	12	and	and	CCONJ
bam-7218	526	13	highly	highly	ADV
bam-7218	526	14	efficient	efficient	ADJ
bam-7218	526	15	differentiation	differentiation	NOUN
bam-7218	526	16	method	method	NOUN
bam-7218	526	17	for	for	ADP
bam-7218	526	18	skeletal	skeletal	ADJ
bam-7218	526	19	muscle	muscle	NOUN
bam-7218	526	20	that	that	PRON
bam-7218	526	21	does	do	AUX
bam-7218	526	22	not	not	PART
bam-7218	526	23	rely	rely	VERB
bam-7218	526	24	on	on	ADP
bam-7218	526	25	the	the	DET
bam-7218	526	26	overexpression	overexpression	NOUN
bam-7218	526	27	of	of	ADP
bam-7218	526	28	myogenic	myogenic	ADJ
bam-7218	526	29	transcription	transcription	NOUN
bam-7218	526	30	factors	factor	NOUN
bam-7218	526	31	or	or	CCONJ
bam-7218	526	32	cell	cell	NOUN
bam-7218	526	33	sorting	sort	VERB
bam-7218	526	34	to	to	PART
bam-7218	526	35	enrich	enrich	VERB
bam-7218	526	36	myogenic	myogenic	ADJ
bam-7218	526	37	populations	population	NOUN
bam-7218	526	38	(	(	PUNCT
bam-7218	526	39	caron	caron	PROPN
bam-7218	526	40	et	et	PROPN
bam-7218	526	41	al	al	PROPN
bam-7218	526	42	.	.	PROPN
bam-7218	526	43	2016	2016	NUM
bam-7218	526	44	)	)	PUNCT
bam-7218	526	45	.	.	PUNCT
bam-7218	527	1	together	together	ADV
bam-7218	527	2	this	this	DET
bam-7218	527	3	technology	technology	NOUN
bam-7218	527	4	provides	provide	VERB
bam-7218	527	5	a	a	DET
bam-7218	527	6	valuable	valuable	ADJ
bam-7218	527	7	platform	platform	NOUN
bam-7218	527	8	to	to	PART
bam-7218	527	9	study	study	VERB
bam-7218	527	10	development	development	NOUN
bam-7218	527	11	and	and	CCONJ
bam-7218	527	12	disease	disease	NOUN
bam-7218	527	13	states	state	NOUN
bam-7218	527	14	in	in	ADP
bam-7218	527	15	fshd	fshd	ADJ
bam-7218	527	16	with	with	ADP
bam-7218	527	17	relevant	relevant	ADJ
bam-7218	527	18	human	human	ADJ
bam-7218	527	19	pathologies	pathology	NOUN
bam-7218	527	20	that	that	PRON
bam-7218	527	21	can	can	AUX
bam-7218	527	22	not	not	PART
bam-7218	527	23	be	be	AUX
bam-7218	527	24	recapitulated	recapitulate	VERB
bam-7218	527	25	in	in	ADP
bam-7218	527	26	animal	animal	NOUN
bam-7218	527	27	models	model	NOUN
bam-7218	527	28	.	.	PUNCT
bam-7218	528	1	it	it	PRON
bam-7218	528	2	also	also	ADV
bam-7218	528	3	provides	provide	VERB
bam-7218	528	4	an	an	DET
bam-7218	528	5	unlimited	unlimited	ADJ
bam-7218	528	6	,	,	PUNCT
bam-7218	528	7	uniform	uniform	ADJ
bam-7218	528	8	resource	resource	NOUN
bam-7218	528	9	to	to	PART
bam-7218	528	10	develop	develop	VERB
bam-7218	528	11	cellbased	cellbase	VERB
bam-7218	528	12	primary	primary	ADJ
bam-7218	528	13	and	and	CCONJ
bam-7218	528	14	secondary	secondary	ADJ
bam-7218	528	15	phenotypic	phenotypic	ADJ
bam-7218	528	16	assays	assay	NOUN
bam-7218	528	17	for	for	ADP
bam-7218	528	18	drug	drug	NOUN
bam-7218	528	19	discovery	discovery	NOUN
bam-7218	528	20	.	.	PUNCT
bam-7218	529	1	here	here	ADV
bam-7218	529	2	,	,	PUNCT
bam-7218	529	3	we	we	PRON
bam-7218	529	4	discuss	discuss	VERB
bam-7218	529	5	our	our	PRON
bam-7218	529	6	recent	recent	ADJ
bam-7218	529	7	findings	finding	NOUN
bam-7218	529	8	on	on	ADP
bam-7218	529	9	dux4	dux4	NOUN
bam-7218	529	10	expression	expression	NOUN
bam-7218	529	11	in	in	ADP
bam-7218	529	12	stem	stem	NOUN
bam-7218	529	13	cell	cell	NOUN
bam-7218	529	14	-	-	PUNCT
bam-7218	529	15	derived	derive	VERB
bam-7218	529	16	myotubes	myotube	NOUN
bam-7218	529	17	,	,	PUNCT
bam-7218	529	18	its	its	PRON
bam-7218	529	19	epigenetic	epigenetic	ADJ
bam-7218	529	20	regulation	regulation	NOUN
bam-7218	529	21	and	and	CCONJ
bam-7218	529	22	secondary	secondary	ADJ
bam-7218	529	23	fshd	fshd	ADJ
bam-7218	529	24	phenotypes	phenotype	NOUN
bam-7218	529	25	observed	observe	VERB
bam-7218	529	26	in	in	ADP
bam-7218	529	27	these	these	DET
bam-7218	529	28	cells	cell	NOUN
bam-7218	529	29	in	in	ADP
bam-7218	529	30	the	the	DET
bam-7218	529	31	context	context	NOUN
bam-7218	529	32	of	of	ADP
bam-7218	529	33	our	our	PRON
bam-7218	529	34	overall	overall	ADJ
bam-7218	529	35	aim	aim	NOUN
bam-7218	529	36	to	to	PART
bam-7218	529	37	develop	develop	VERB
bam-7218	529	38	a	a	DET
bam-7218	529	39	small	small	ADJ
bam-7218	529	40	molecule	molecule	NOUN
bam-7218	529	41	drug	drug	NOUN
bam-7218	529	42	to	to	PART
bam-7218	529	43	treat	treat	VERB
bam-7218	529	44	fshd	fshd	ADJ
bam-7218	529	45	patients	patient	NOUN
bam-7218	529	46	.	.	PUNCT
bam-7218	530	1	4.7	4.7	NUM
bam-7218	530	2	novel	novel	ADJ
bam-7218	530	3	zebrafish	zebrafish	ADJ
bam-7218	530	4	models	model	NOUN
bam-7218	530	5	of	of	ADP
bam-7218	530	6	sarcoglycanopathy	sarcoglycanopathy	PROPN
bam-7218	530	7	michela	michela	PROPN
bam-7218	530	8	soardi	soardi	PROPN
bam-7218	530	9	,	,	PUNCT
bam-7218	530	10	(	(	PUNCT
bam-7218	530	11	a	a	X
bam-7218	530	12	)	)	PUNCT
bam-7218	530	13	,	,	PUNCT
bam-7218	530	14	marcello	marcello	PROPN
bam-7218	530	15	carotti	carotti	PROPN
bam-7218	530	16	(	(	PUNCT
bam-7218	530	17	a	a	NOUN
bam-7218	530	18	)	)	PUNCT
bam-7218	530	19	,	,	PUNCT
bam-7218	530	20	chiara	chiara	X
bam-7218	530	21	fecchio	fecchio	X
bam-7218	530	22	(	(	PUNCT
bam-7218	530	23	a	a	NOUN
bam-7218	530	24	)	)	PUNCT
bam-7218	530	25	,	,	PUNCT
bam-7218	530	26	roberta	roberta	PROPN
bam-7218	530	27	sacchetto	sacchetto	PROPN
bam-7218	530	28	(	(	PUNCT
bam-7218	530	29	b	b	NOUN
bam-7218	530	30	)	)	PUNCT
bam-7218	530	31	,	,	PUNCT
bam-7218	530	32	dorianna	dorianna	NOUN
bam-7218	530	33	sandonà	sandonà	PROPN
bam-7218	530	34	(	(	PUNCT
bam-7218	530	35	a	a	NOUN
bam-7218	530	36	)	)	PUNCT
bam-7218	530	37	(	(	PUNCT
bam-7218	530	38	a	a	X
bam-7218	530	39	)	)	PUNCT
bam-7218	530	40	dept	dept	NOUN
bam-7218	530	41	of	of	ADP
bam-7218	530	42	biomedical	biomedical	ADJ
bam-7218	530	43	sciences	science	NOUN
bam-7218	530	44	;	;	PUNCT
bam-7218	530	45	(	(	PUNCT
bam-7218	530	46	2	2	X
bam-7218	530	47	)	)	PUNCT
bam-7218	530	48	dept	dept	NOUN
bam-7218	530	49	of	of	ADP
bam-7218	530	50	comparative	comparative	ADJ
bam-7218	530	51	biomedicine	biomedicine	NOUN
bam-7218	530	52	and	and	CCONJ
bam-7218	530	53	food	food	NOUN
bam-7218	530	54	science	science	NOUN
bam-7218	530	55	,	,	PUNCT
bam-7218	530	56	university	university	PROPN
bam-7218	530	57	of	of	ADP
bam-7218	530	58	padova	padova	PROPN
bam-7218	530	59	,	,	PUNCT
bam-7218	530	60	italy	italy	PROPN
bam-7218	530	61	.	.	PUNCT
bam-7218	531	1	e	e	X
bam-7218	531	2	-	-	NOUN
bam-7218	531	3	mail	mail	NOUN
bam-7218	531	4	:	:	PUNCT
bam-7218	532	1	michelasoardi@gmail.com	michelasoardi@gmail.com	PROPN
bam-7218	532	2	sarcoglycanopathy	sarcoglycanopathy	PROPN
bam-7218	532	3	is	be	AUX
bam-7218	532	4	the	the	DET
bam-7218	532	5	collective	collective	ADJ
bam-7218	532	6	name	name	NOUN
bam-7218	532	7	of	of	ADP
bam-7218	532	8	four	four	NUM
bam-7218	532	9	rare	rare	ADJ
bam-7218	532	10	genetic	genetic	ADJ
bam-7218	532	11	diseases	disease	NOUN
bam-7218	532	12	caused	cause	VERB
bam-7218	532	13	by	by	ADP
bam-7218	532	14	defects	defect	NOUN
bam-7218	532	15	in	in	ADP
bam-7218	532	16	the	the	DET
bam-7218	532	17	genes	gene	NOUN
bam-7218	532	18	coding	code	VERB
bam-7218	532	19	for	for	ADP
bam-7218	532	20	alpha-	alpha-	NOUN
bam-7218	532	21	,	,	PUNCT
bam-7218	532	22	beta-	beta-	NOUN
bam-7218	532	23	,	,	PUNCT
bam-7218	532	24	gammaand	gammaand	NOUN
bam-7218	532	25	delta	delta	NOUN
bam-7218	532	26	-	-	PUNCT
bam-7218	532	27	sarcoglycan	sarcoglycan	NOUN
bam-7218	532	28	(	(	PUNCT
bam-7218	532	29	sg	sg	PROPN
bam-7218	532	30	)	)	PUNCT
bam-7218	532	31	,	,	PUNCT
bam-7218	532	32	which	which	PRON
bam-7218	532	33	form	form	VERB
bam-7218	532	34	a	a	DET
bam-7218	532	35	key	key	ADJ
bam-7218	532	36	structural	structural	ADJ
bam-7218	532	37	complex	complex	NOUN
bam-7218	532	38	that	that	PRON
bam-7218	532	39	assures	assure	VERB
bam-7218	532	40	sarcolemma	sarcolemma	PROPN
bam-7218	532	41	stability	stability	NOUN
bam-7218	532	42	during	during	ADP
bam-7218	532	43	muscle	muscle	NOUN
bam-7218	532	44	contraction	contraction	NOUN
bam-7218	532	45	.	.	PUNCT
bam-7218	533	1	most	most	ADJ
bam-7218	533	2	of	of	ADP
bam-7218	533	3	the	the	DET
bam-7218	533	4	reported	report	VERB
bam-7218	533	5	cases	case	NOUN
bam-7218	533	6	of	of	ADP
bam-7218	533	7	sarcoglycanopathy	sarcoglycanopathy	NOUN
bam-7218	533	8	are	be	AUX
bam-7218	533	9	due	due	ADJ
bam-7218	533	10	to	to	PART
bam-7218	533	11	missense	missense	VERB
bam-7218	533	12	mutations	mutation	NOUN
bam-7218	533	13	.	.	PUNCT
bam-7218	534	1	the	the	DET
bam-7218	534	2	resulting	result	VERB
bam-7218	534	3	folding	folding	NOUN
bam-7218	534	4	-	-	PUNCT
bam-7218	534	5	defective	defective	ADJ
bam-7218	534	6	sg	sg	NOUN
bam-7218	534	7	is	be	AUX
bam-7218	534	8	degraded	degrade	VERB
bam-7218	534	9	by	by	ADP
bam-7218	534	10	the	the	DET
bam-7218	534	11	quality	quality	NOUN
bam-7218	534	12	control	control	NOUN
bam-7218	534	13	of	of	ADP
bam-7218	534	14	the	the	DET
bam-7218	534	15	cell	cell	NOUN
bam-7218	534	16	,	,	PUNCT
bam-7218	534	17	leading	lead	VERB
bam-7218	534	18	to	to	ADP
bam-7218	534	19	the	the	DET
bam-7218	534	20	secondary	secondary	ADJ
bam-7218	534	21	deficiency	deficiency	NOUN
bam-7218	534	22	of	of	ADP
bam-7218	534	23	the	the	DET
bam-7218	534	24	wild	wild	ADJ
bam-7218	534	25	type	type	NOUN
bam-7218	534	26	partners	partner	NOUN
bam-7218	534	27	.	.	PUNCT
bam-7218	535	1	many	many	ADJ
bam-7218	535	2	missense	missense	NOUN
bam-7218	535	3	mutants	mutant	NOUN
bam-7218	535	4	retain	retain	VERB
bam-7218	535	5	their	their	PRON
bam-7218	535	6	function	function	NOUN
bam-7218	535	7	as	as	SCONJ
bam-7218	535	8	the	the	DET
bam-7218	535	9	entire	entire	ADJ
bam-7218	535	10	sg	sg	NOUN
bam-7218	535	11	-	-	PUNCT
bam-7218	535	12	complex	complex	NOUN
bam-7218	535	13	can	can	AUX
bam-7218	535	14	be	be	AUX
bam-7218	535	15	properly	properly	ADV
bam-7218	535	16	rescued	rescue	VERB
bam-7218	535	17	by	by	ADP
bam-7218	535	18	skipping	skip	VERB
bam-7218	535	19	the	the	DET
bam-7218	535	20	degradation	degradation	NOUN
bam-7218	535	21	of	of	ADP
bam-7218	535	22	the	the	DET
bam-7218	535	23	defective	defective	ADJ
bam-7218	535	24	protein	protein	NOUN
bam-7218	535	25	.	.	PUNCT
bam-7218	536	1	presently	presently	ADV
bam-7218	536	2	,	,	PUNCT
bam-7218	536	3	major	major	ADJ
bam-7218	536	4	effort	effort	NOUN
bam-7218	536	5	is	be	AUX
bam-7218	536	6	devoted	devote	VERB
bam-7218	536	7	to	to	ADP
bam-7218	536	8	the	the	DET
bam-7218	536	9	development	development	NOUN
bam-7218	536	10	of	of	ADP
bam-7218	536	11	novel	novel	ADJ
bam-7218	536	12	therapeutic	therapeutic	ADJ
bam-7218	536	13	approaches	approach	NOUN
bam-7218	536	14	based	base	VERB
bam-7218	536	15	on	on	ADP
bam-7218	536	16	the	the	DET
bam-7218	536	17	use	use	NOUN
bam-7218	536	18	of	of	ADP
bam-7218	536	19	smallmolecules	smallmolecule	NOUN
bam-7218	536	20	either	either	CCONJ
bam-7218	536	21	inhibiting	inhibit	VERB
bam-7218	536	22	the	the	DET
bam-7218	536	23	degradation	degradation	NOUN
bam-7218	536	24	or	or	CCONJ
bam-7218	536	25	helping	help	VERB
bam-7218	536	26	the	the	DET
bam-7218	536	27	folding	fold	VERB
bam-7218	536	28	process	process	NOUN
bam-7218	536	29	of	of	ADP
bam-7218	536	30	sg	sg	PROPN
bam-7218	536	31	mutants	mutant	NOUN
bam-7218	536	32	.	.	PUNCT
bam-7218	537	1	indeed	indeed	ADV
bam-7218	537	2	,	,	PUNCT
bam-7218	537	3	the	the	DET
bam-7218	537	4	application	application	NOUN
bam-7218	537	5	of	of	ADP
bam-7218	537	6	this	this	DET
bam-7218	537	7	strategy	strategy	NOUN
bam-7218	537	8	allowed	allow	VERB
bam-7218	537	9	the	the	DET
bam-7218	537	10	recovery	recovery	NOUN
bam-7218	537	11	of	of	ADP
bam-7218	537	12	the	the	DET
bam-7218	537	13	sg	sg	NOUN
bam-7218	537	14	-	-	PUNCT
bam-7218	537	15	complex	complex	NOUN
bam-7218	537	16	in	in	ADP
bam-7218	537	17	both	both	DET
bam-7218	537	18	cell	cell	NOUN
bam-7218	537	19	models	model	NOUN
bam-7218	537	20	and	and	CCONJ
bam-7218	537	21	,	,	PUNCT
bam-7218	537	22	notably	notably	ADV
bam-7218	537	23	,	,	PUNCT
bam-7218	537	24	primary	primary	ADJ
bam-7218	537	25	myotubes	myotube	NOUN
bam-7218	537	26	from	from	ADP
bam-7218	537	27	a	a	DET
bam-7218	537	28	patient	patient	NOUN
bam-7218	537	29	with	with	ADP
bam-7218	537	30	sarcoglycanopathy	sarcoglycanopathy	PROPN
bam-7218	537	31	.	.	PUNCT
bam-7218	538	1	to	to	PART
bam-7218	538	2	confirm	confirm	VERB
bam-7218	538	3	in	in	ADP
bam-7218	538	4	vivo	vivo	ADJ
bam-7218	538	5	efficacy	efficacy	NOUN
bam-7218	538	6	and	and	CCONJ
bam-7218	538	7	tolerability	tolerability	NOUN
bam-7218	538	8	of	of	ADP
bam-7218	538	9	this	this	DET
bam-7218	538	10	successful	successful	ADJ
bam-7218	538	11	strategy	strategy	NOUN
bam-7218	538	12	,	,	PUNCT
bam-7218	538	13	we	we	PRON
bam-7218	538	14	are	be	AUX
bam-7218	538	15	now	now	ADV
bam-7218	538	16	generating	generate	VERB
bam-7218	538	17	novel	novel	ADJ
bam-7218	538	18	sarcoglycanopathy	sarcoglycanopathy	ADJ
bam-7218	538	19	models	model	NOUN
bam-7218	538	20	in	in	ADP
bam-7218	538	21	zebrafish	zebrafish	ADJ
bam-7218	538	22	,	,	PUNCT
bam-7218	538	23	which	which	PRON
bam-7218	538	24	will	will	AUX
bam-7218	538	25	carry	carry	VERB
bam-7218	538	26	a	a	DET
bam-7218	538	27	mutated	mutate	VERB
bam-7218	538	28	sg	sg	NOUN
bam-7218	538	29	,	,	PUNCT
bam-7218	538	30	recoverable	recoverable	NOUN
bam-7218	538	31	by	by	ADP
bam-7218	538	32	drug	drug	NOUN
bam-7218	538	33	treatment	treatment	NOUN
bam-7218	538	34	.	.	PUNCT
bam-7218	539	1	we	we	PRON
bam-7218	539	2	are	be	AUX
bam-7218	539	3	focused	focus	VERB
bam-7218	539	4	on	on	ADP
bam-7218	539	5	zebrafish	zebrafish	ADJ
bam-7218	539	6	because	because	SCONJ
bam-7218	539	7	it	it	PRON
bam-7218	539	8	is	be	AUX
bam-7218	539	9	an	an	DET
bam-7218	539	10	excellent	excellent	ADJ
bam-7218	539	11	vertebrate	vertebrate	NOUN
bam-7218	539	12	model	model	NOUN
bam-7218	539	13	for	for	ADP
bam-7218	539	14	muscular	muscular	ADJ
bam-7218	539	15	disorders	disorder	NOUN
bam-7218	539	16	,	,	PUNCT
bam-7218	539	17	drug	drug	NOUN
bam-7218	539	18	screening	screening	NOUN
bam-7218	539	19	,	,	PUNCT
bam-7218	539	20	and	and	CCONJ
bam-7218	539	21	it	it	PRON
bam-7218	539	22	is	be	AUX
bam-7218	539	23	relatively	relatively	ADV
bam-7218	539	24	easy	easy	ADJ
bam-7218	539	25	to	to	PART
bam-7218	539	26	introduce	introduce	VERB
bam-7218	539	27	any	any	DET
bam-7218	539	28	desired	desire	VERB
bam-7218	539	29	mutation	mutation	NOUN
bam-7218	539	30	by	by	ADP
bam-7218	539	31	genome	genome	NOUN
bam-7218	539	32	-	-	PUNCT
bam-7218	539	33	editing	edit	VERB
bam-7218	539	34	technologies	technology	NOUN
bam-7218	539	35	.	.	PUNCT
bam-7218	540	1	here	here	ADV
bam-7218	540	2	we	we	PRON
bam-7218	540	3	report	report	VERB
bam-7218	540	4	data	datum	NOUN
bam-7218	540	5	showing	show	VERB
bam-7218	540	6	knock	knock	NOUN
bam-7218	540	7	-	-	PUNCT
bam-7218	540	8	down	down	NOUN
bam-7218	540	9	of	of	ADP
bam-7218	540	10	delta	delta	NOUN
bam-7218	540	11	-	-	PUNCT
bam-7218	540	12	sg	sg	PROPN
bam-7218	540	13	in	in	ADP
bam-7218	540	14	zebrafish	zebrafish	NUM
bam-7218	540	15	,	,	PUNCT
bam-7218	540	16	that	that	PRON
bam-7218	540	17	leads	lead	VERB
bam-7218	540	18	to	to	ADP
bam-7218	540	19	severe	severe	ADJ
bam-7218	540	20	muscular	muscular	ADJ
bam-7218	540	21	abnormalities	abnormality	NOUN
bam-7218	540	22	,	,	PUNCT
bam-7218	540	23	well	well	ADV
bam-7218	540	24	mimicking	mimic	VERB
bam-7218	540	25	the	the	DET
bam-7218	540	26	human	human	ADJ
bam-7218	540	27	disease	disease	NOUN
bam-7218	540	28	,	,	PUNCT
bam-7218	540	29	and	and	CCONJ
bam-7218	540	30	first	first	ADJ
bam-7218	540	31	results	result	NOUN
bam-7218	540	32	concerning	concern	VERB
bam-7218	540	33	the	the	DET
bam-7218	540	34	generation	generation	NOUN
bam-7218	540	35	of	of	ADP
bam-7218	540	36	beta	beta	NOUN
bam-7218	540	37	-	-	PUNCT
bam-7218	540	38	sg	sg	PROPN
bam-7218	540	39	and	and	CCONJ
bam-7218	540	40	delta	delta	NOUN
bam-7218	540	41	-	-	PUNCT
bam-7218	540	42	sg	sg	NOUN
bam-7218	540	43	knock	knock	NOUN
bam-7218	540	44	-	-	PUNCT
bam-7218	540	45	in	in	NOUN
bam-7218	540	46	and	and	CCONJ
bam-7218	540	47	knock	knock	VERB
bam-7218	540	48	-	-	PUNCT
bam-7218	540	49	out	out	ADP
bam-7218	540	50	zebrafish	zebrafish	ADJ
bam-7218	540	51	lines	line	NOUN
bam-7218	540	52	by	by	ADP
bam-7218	540	53	the	the	DET
bam-7218	540	54	crispr	crispr	ADJ
bam-7218	540	55	/	/	SYM
bam-7218	540	56	cas9	cas9	NOUN
bam-7218	540	57	technique	technique	NOUN
bam-7218	540	58	.	.	PUNCT
bam-7218	541	1	october	october	PROPN
bam-7218	541	2	14	14	NUM
bam-7218	541	3	h	h	NOUN
bam-7218	541	4	session	session	NOUN
bam-7218	541	5	5	5	NUM
bam-7218	541	6	metabolic	metabolic	NOUN
bam-7218	541	7	alterations	alteration	NOUN
bam-7218	541	8	and	and	CCONJ
bam-7218	541	9	muscle	muscle	NOUN
bam-7218	541	10	diseases	disease	NOUN
bam-7218	541	11	5.1	5.1	NUM
bam-7218	541	12	cynidin	cynidin	VERB
bam-7218	541	13	enriched	enrich	VERB
bam-7218	541	14	diet	diet	NOUN
bam-7218	541	15	delays	delay	NOUN
bam-7218	541	16	muscular	muscular	ADJ
bam-7218	541	17	dystrophy	dystrophy	NOUN
bam-7218	541	18	in	in	ADP
bam-7218	541	19	alpha	alpha	NOUN
bam-7218	541	20	-	-	ADJ
bam-7218	541	21	sarcoglycan	sarcoglycan	ADJ
bam-7218	541	22	null	null	ADJ
bam-7218	541	23	mice	mice	PROPN
bam-7218	541	24	enrico	enrico	PROPN
bam-7218	541	25	caruso	caruso	PROPN
bam-7218	541	26	,	,	PUNCT
bam-7218	541	27	marielle	marielle	PROPN
bam-7218	541	28	saclier	saclier	PROPN
bam-7218	541	29	,	,	PUNCT
bam-7218	541	30	stefania	stefania	PROPN
bam-7218	541	31	antonini	antonini	PROPN
bam-7218	541	32	,	,	PUNCT
bam-7218	541	33	chiara	chiara	PROPN
bam-7218	541	34	bonfanti	bonfanti	PROPN
bam-7218	541	35	,	,	PUNCT
bam-7218	541	36	katia	katia	PROPN
bam-7218	541	37	petroni	petroni	PROPN
bam-7218	541	38	,	,	PUNCT
bam-7218	541	39	chiara	chiara	PROPN
bam-7218	541	40	tonelli	tonelli	PROPN
bam-7218	541	41	,	,	PUNCT
bam-7218	541	42	graziella	graziella	PROPN
bam-7218	541	43	messina	messina	PROPN
bam-7218	541	44	università	università	PROPN
bam-7218	541	45	degli	degli	PROPN
bam-7218	541	46	studi	studi	PROPN
bam-7218	541	47	di	di	X
bam-7218	541	48	milano	milano	PROPN
bam-7218	541	49	,	,	PUNCT
bam-7218	541	50	italy	italy	PROPN
bam-7218	541	51	.	.	PUNCT
bam-7218	542	1	e	e	X
bam-7218	542	2	-	-	NOUN
bam-7218	542	3	mail	mail	NOUN
bam-7218	542	4	:	:	PUNCT
bam-7218	542	5	enrico.caruso@unimi.it	enrico.caruso@unimi.it	VERB
bam-7218	542	6	muscular	muscular	ADJ
bam-7218	542	7	dystrophies	dystrophy	NOUN
bam-7218	542	8	(	(	PUNCT
bam-7218	542	9	md	md	PROPN
bam-7218	542	10	)	)	PUNCT
bam-7218	542	11	are	be	AUX
bam-7218	542	12	genetic	genetic	ADJ
bam-7218	542	13	diseases	disease	NOUN
bam-7218	542	14	,	,	PUNCT
bam-7218	542	15	all	all	PRON
bam-7218	542	16	characterized	characterize	VERB
bam-7218	542	17	by	by	ADP
bam-7218	542	18	a	a	DET
bam-7218	542	19	progressive	progressive	ADJ
bam-7218	542	20	muscle	muscle	NOUN
bam-7218	542	21	wasting	waste	VERB
bam-7218	542	22	in	in	ADP
bam-7218	542	23	time	time	NOUN
bam-7218	542	24	,	,	PUNCT
bam-7218	542	25	leading	lead	VERB
bam-7218	542	26	patients	patient	NOUN
bam-7218	542	27	to	to	PART
bam-7218	542	28	wheelchair	wheelchair	VERB
bam-7218	542	29	and	and	CCONJ
bam-7218	542	30	premature	premature	ADJ
bam-7218	542	31	death	death	NOUN
bam-7218	542	32	caused	cause	VERB
bam-7218	542	33	by	by	ADP
bam-7218	542	34	respiratory	respiratory	ADJ
bam-7218	542	35	and	and	CCONJ
bam-7218	542	36	cardiac	cardiac	ADJ
bam-7218	542	37	failure	failure	NOUN
bam-7218	542	38	.	.	PUNCT
bam-7218	543	1	nowadays	nowadays	ADV
bam-7218	543	2	there	there	PRON
bam-7218	543	3	is	be	VERB
bam-7218	543	4	still	still	ADV
bam-7218	543	5	no	no	DET
bam-7218	543	6	definitive	definitive	ADJ
bam-7218	543	7	cure	cure	NOUN
bam-7218	543	8	for	for	ADP
bam-7218	543	9	these	these	DET
bam-7218	543	10	pathologies	pathology	NOUN
bam-7218	543	11	.	.	PUNCT
bam-7218	544	1	only	only	ADV
bam-7218	544	2	chronic	chronic	ADJ
bam-7218	544	3	treatment	treatment	NOUN
bam-7218	544	4	of	of	ADP
bam-7218	544	5	corticosteroids	corticosteroid	NOUN
bam-7218	544	6	is	be	AUX
bam-7218	544	7	widely	widely	ADV
bam-7218	544	8	used	use	VERB
bam-7218	544	9	to	to	PART
bam-7218	544	10	slow	slow	VERB
bam-7218	544	11	down	down	ADP
bam-7218	544	12	the	the	DET
bam-7218	544	13	symptoms	symptom	NOUN
bam-7218	544	14	,	,	PUNCT
bam-7218	544	15	but	but	CCONJ
bam-7218	544	16	with	with	ADP
bam-7218	544	17	several	several	ADJ
bam-7218	544	18	sides	side	NOUN
bam-7218	544	19	effects	effect	NOUN
bam-7218	544	20	for	for	ADP
bam-7218	544	21	the	the	DET
bam-7218	544	22	patients	patient	NOUN
bam-7218	544	23	.	.	PUNCT
bam-7218	545	1	it	it	PRON
bam-7218	545	2	is	be	AUX
bam-7218	545	3	also	also	ADV
bam-7218	545	4	known	know	VERB
bam-7218	545	5	the	the	DET
bam-7218	545	6	myofibers	myofiber	NOUN
bam-7218	545	7	affected	affect	VERB
bam-7218	545	8	by	by	ADP
bam-7218	545	9	md	md	PROPN
bam-7218	545	10	are	be	AUX
bam-7218	545	11	more	more	ADV
bam-7218	545	12	susceptible	susceptible	ADJ
bam-7218	545	13	to	to	ADP
bam-7218	545	14	oxidative	oxidative	ADJ
bam-7218	545	15	stress	stress	NOUN
bam-7218	545	16	than	than	ADP
bam-7218	545	17	healthy	healthy	ADJ
bam-7218	545	18	fibers	fiber	NOUN
bam-7218	545	19	due	due	ADJ
bam-7218	545	20	to	to	ADP
bam-7218	545	21	a	a	DET
bam-7218	545	22	lacking	lacking	NOUN
bam-7218	545	23	of	of	ADP
bam-7218	545	24	antioxidant	antioxidant	ADJ
bam-7218	545	25	signal	signal	NOUN
bam-7218	545	26	.	.	PUNCT
bam-7218	546	1	in	in	ADP
bam-7218	546	2	this	this	DET
bam-7218	546	3	study	study	NOUN
bam-7218	546	4	we	we	PRON
bam-7218	546	5	investigate	investigate	VERB
bam-7218	546	6	on	on	ADP
bam-7218	546	7	the	the	DET
bam-7218	546	8	effects	effect	NOUN
bam-7218	546	9	of	of	ADP
bam-7218	546	10	a	a	DET
bam-7218	546	11	diet	diet	NOUN
bam-7218	546	12	enriched	enrich	VERB
bam-7218	546	13	with	with	ADP
bam-7218	546	14	a	a	DET
bam-7218	546	15	natural	natural	ADJ
bam-7218	546	16	antioxidant	antioxidant	NOUN
bam-7218	546	17	(	(	PUNCT
bam-7218	546	18	cyanidin	cyanidin	NOUN
bam-7218	546	19	,	,	PUNCT
bam-7218	546	20	red	red	PROPN
bam-7218	546	21	diet	diet	PROPN
bam-7218	546	22	rd	rd	PROPN
bam-7218	546	23	)	)	PUNCT
bam-7218	546	24	on	on	ADP
bam-7218	546	25	the	the	DET
bam-7218	546	26	dystrophic	dystrophic	ADJ
bam-7218	546	27	mouse	mouse	NOUN
bam-7218	546	28	model	model	NOUN
bam-7218	546	29	sgca	sgca	NOUN
bam-7218	546	30	null	null	NOUN
bam-7218	546	31	.	.	PUNCT
bam-7218	547	1	we	we	PRON
bam-7218	547	2	mailto:uli.schmidt@geneabiocells.com	mailto:uli.schmidt@geneabiocells.com	X
bam-7218	547	3	mailto:michelasoardi@gmail.com	mailto:michelasoardi@gmail.com	X
bam-7218	548	1	mailto:enrico.caruso@unimi.it	mailto:enrico.caruso@unimi.it	PROPN
bam-7218	548	2	14	14	NUM
bam-7218	548	3	th	th	NOUN
bam-7218	548	4	iiim	iiim	NOUN
bam-7218	548	5	meeting	meeting	NOUN
bam-7218	548	6	,	,	PUNCT
bam-7218	548	7	assisi	assisi	PROPN
bam-7218	548	8	,	,	PUNCT
bam-7218	548	9	italy	italy	PROPN
bam-7218	548	10	october	october	PROPN
bam-7218	548	11	12	12	NUM
bam-7218	548	12	-	-	SYM
bam-7218	548	13	15	15	NUM
bam-7218	548	14	2017	2017	NUM
bam-7218	548	15	eur	eur	PROPN
bam-7218	548	16	j	j	PROPN
bam-7218	548	17	transl	transl	PROPN
bam-7218	548	18	myol	myol	ADV
bam-7218	548	19	27	27	NUM
bam-7218	548	20	(	(	PUNCT
bam-7218	548	21	4	4	NUM
bam-7218	548	22	):	):	SYM
bam-7218	548	23	185	185	NUM
bam-7218	548	24	-	-	SYM
bam-7218	548	25	224	224	NUM
bam-7218	548	26	201	201	NUM
bam-7218	548	27	observed	observe	VERB
bam-7218	548	28	a	a	DET
bam-7218	548	29	delay	delay	NOUN
bam-7218	548	30	on	on	ADP
bam-7218	548	31	the	the	DET
bam-7218	548	32	typical	typical	ADJ
bam-7218	548	33	markers	marker	NOUN
bam-7218	548	34	of	of	ADP
bam-7218	548	35	the	the	DET
bam-7218	548	36	md	md	PROPN
bam-7218	548	37	onset	onset	NOUN
bam-7218	548	38	,	,	PUNCT
bam-7218	548	39	as	as	ADP
bam-7218	548	40	more	more	ADV
bam-7218	548	41	homogeneous	homogeneous	ADJ
bam-7218	548	42	csa	csa	PROPN
bam-7218	548	43	distribution	distribution	NOUN
bam-7218	548	44	,	,	PUNCT
bam-7218	548	45	reduction	reduction	NOUN
bam-7218	548	46	of	of	ADP
bam-7218	548	47	fibrosis	fibrosis	NOUN
bam-7218	548	48	and	and	CCONJ
bam-7218	548	49	also	also	ADV
bam-7218	548	50	a	a	DET
bam-7218	548	51	rescue	rescue	NOUN
bam-7218	548	52	in	in	ADP
bam-7218	548	53	the	the	DET
bam-7218	548	54	muscle	muscle	NOUN
bam-7218	548	55	performance	performance	NOUN
bam-7218	548	56	.	.	PUNCT
bam-7218	549	1	we	we	PRON
bam-7218	549	2	also	also	ADV
bam-7218	549	3	addressed	address	VERB
bam-7218	549	4	the	the	DET
bam-7218	549	5	molecular	molecular	ADJ
bam-7218	549	6	pathways	pathway	NOUN
bam-7218	549	7	triggered	trigger	VERB
bam-7218	549	8	by	by	ADP
bam-7218	549	9	rd	rd	PROPN
bam-7218	549	10	,	,	PUNCT
bam-7218	549	11	identifying	identify	VERB
bam-7218	549	12	an	an	DET
bam-7218	549	13	exclusion	exclusion	NOUN
bam-7218	549	14	of	of	ADP
bam-7218	549	15	the	the	DET
bam-7218	549	16	transcription	transcription	NOUN
bam-7218	549	17	factor	factor	NOUN
bam-7218	549	18	nf	nf	NOUN
bam-7218	549	19	-	-	PUNCT
bam-7218	549	20	kb	kb	PROPN
bam-7218	549	21	from	from	ADP
bam-7218	549	22	the	the	DET
bam-7218	549	23	myonuclei	myonuclei	NOUN
bam-7218	549	24	as	as	ADP
bam-7218	549	25	an	an	DET
bam-7218	549	26	anti	anti	ADJ
bam-7218	549	27	-	-	ADJ
bam-7218	549	28	inflammatory	inflammatory	ADJ
bam-7218	549	29	pathway	pathway	NOUN
bam-7218	549	30	.	.	PUNCT
bam-7218	550	1	on	on	ADP
bam-7218	550	2	the	the	DET
bam-7218	550	3	other	other	ADJ
bam-7218	550	4	side	side	NOUN
bam-7218	550	5	we	we	PRON
bam-7218	550	6	found	find	VERB
bam-7218	550	7	that	that	SCONJ
bam-7218	550	8	rd	rd	PROPN
bam-7218	550	9	promotes	promote	VERB
bam-7218	550	10	nrf-2	nrf-2	NUM
bam-7218	550	11	translocation	translocation	NOUN
bam-7218	550	12	into	into	ADP
bam-7218	550	13	the	the	DET
bam-7218	550	14	nuclei	nucleus	NOUN
bam-7218	550	15	to	to	PART
bam-7218	550	16	trigger	trigger	VERB
bam-7218	550	17	an	an	DET
bam-7218	550	18	antioxidant	antioxidant	ADJ
bam-7218	550	19	response	response	NOUN
bam-7218	550	20	through	through	ADP
bam-7218	550	21	ampk	ampk	NOUN
bam-7218	550	22	activity	activity	NOUN
bam-7218	550	23	.	.	PUNCT
bam-7218	551	1	5.2	5.2	NUM
bam-7218	551	2	high	high	ADJ
bam-7218	551	3	intensity	intensity	NOUN
bam-7218	551	4	exercise	exercise	NOUN
bam-7218	551	5	induced	induce	VERB
bam-7218	551	6	muscle	muscle	NOUN
bam-7218	551	7	remodelling	remodelling	NOUN
bam-7218	551	8	requires	require	VERB
bam-7218	551	9	histone	histone	NOUN
bam-7218	551	10	modifications	modification	NOUN
bam-7218	551	11	and	and	CCONJ
bam-7218	551	12	increased	increase	VERB
bam-7218	551	13	mrtf	mrtf	NOUN
bam-7218	551	14	-	-	PUNCT
bam-7218	551	15	srf	srf	NOUN
bam-7218	551	16	signaling	signal	VERB
bam-7218	551	17	francesca	francesca	PROPN
bam-7218	551	18	solagna	solagna	PROPN
bam-7218	551	19	(	(	PUNCT
bam-7218	551	20	a	a	DET
bam-7218	551	21	,	,	PUNCT
bam-7218	551	22	c	c	NOUN
bam-7218	551	23	)	)	PUNCT
bam-7218	551	24	,	,	PUNCT
bam-7218	552	1	leonardo	leonardo	PROPN
bam-7218	552	2	nogara	nogara	NOUN
bam-7218	552	3	(	(	PUNCT
bam-7218	552	4	a	a	DET
bam-7218	552	5	,	,	PUNCT
bam-7218	552	6	c	c	NOUN
bam-7218	552	7	)	)	PUNCT
bam-7218	552	8	,	,	PUNCT
bam-7218	552	9	kenneth	kenneth	PROPN
bam-7218	552	10	a.	a.	PROPN
bam-7218	552	11	dyar	dyar	PROPN
bam-7218	552	12	(	(	PUNCT
bam-7218	552	13	b	b	NOUN
bam-7218	552	14	)	)	PUNCT
bam-7218	552	15	,	,	PUNCT
bam-7218	552	16	francesco	francesco	PROPN
bam-7218	552	17	chemello	chemello	PROPN
bam-7218	552	18	(	(	PUNCT
bam-7218	552	19	c	c	NOUN
bam-7218	552	20	)	)	PUNCT
bam-7218	552	21	,	,	PUNCT
bam-7218	552	22	henriette	henriette	PROPN
bam-7218	552	23	uhlenhaut	uhlenhaut	PROPN
bam-7218	552	24	(	(	PUNCT
bam-7218	552	25	d	d	PROPN
bam-7218	552	26	)	)	PUNCT
bam-7218	552	27	,	,	PUNCT
bam-7218	552	28	kristian	kristian	PROPN
bam-7218	552	29	vissing	visse	VERB
bam-7218	552	30	(	(	PUNCT
bam-7218	552	31	d	d	PROPN
bam-7218	552	32	)	)	PUNCT
bam-7218	552	33	,	,	PUNCT
bam-7218	552	34	marcus	marcus	PROPN
bam-7218	552	35	kruger	kruger	PROPN
bam-7218	552	36	(	(	PUNCT
bam-7218	552	37	c	c	PROPN
bam-7218	552	38	)	)	PUNCT
bam-7218	552	39	,	,	PUNCT
bam-7218	552	40	bert	bert	PROPN
bam-7218	552	41	blaauw	blaauw	NOUN
bam-7218	552	42	(	(	PUNCT
bam-7218	552	43	a	a	DET
bam-7218	552	44	,	,	PUNCT
bam-7218	552	45	c	c	NOUN
bam-7218	552	46	)	)	PUNCT
bam-7218	552	47	(	(	PUNCT
bam-7218	552	48	a	a	X
bam-7218	552	49	)	)	PUNCT
bam-7218	552	50	venetian	venetian	ADJ
bam-7218	552	51	institute	institute	NOUN
bam-7218	552	52	of	of	ADP
bam-7218	552	53	molecular	molecular	ADJ
bam-7218	552	54	medicine	medicine	NOUN
bam-7218	552	55	,	,	PUNCT
bam-7218	552	56	university	university	NOUN
bam-7218	552	57	of	of	ADP
bam-7218	552	58	padova	padova	PROPN
bam-7218	552	59	;	;	PUNCT
bam-7218	552	60	(	(	PUNCT
bam-7218	552	61	b	b	X
bam-7218	552	62	)	)	PUNCT
bam-7218	552	63	helmholtz	helmholtz	NOUN
bam-7218	552	64	-	-	PUNCT
bam-7218	552	65	zentrum	zentrum	PROPN
bam-7218	552	66	,	,	PUNCT
bam-7218	552	67	münchen	münchen	PROPN
bam-7218	552	68	,	,	PUNCT
bam-7218	552	69	germany	germany	PROPN
bam-7218	552	70	;	;	PUNCT
bam-7218	552	71	(	(	PUNCT
bam-7218	552	72	c	c	X
bam-7218	552	73	)	)	PUNCT
bam-7218	552	74	dept	dept	NOUN
bam-7218	552	75	of	of	ADP
bam-7218	552	76	biomedical	biomedical	ADJ
bam-7218	552	77	sciences	sciences	PROPN
bam-7218	552	78	,	,	PUNCT
bam-7218	552	79	university	university	NOUN
bam-7218	552	80	of	of	ADP
bam-7218	552	81	padova	padova	PROPN
bam-7218	552	82	,	,	PUNCT
bam-7218	552	83	italy	italy	PROPN
bam-7218	552	84	;	;	PUNCT
bam-7218	552	85	(	(	PUNCT
bam-7218	552	86	d	d	X
bam-7218	552	87	)	)	PUNCT
bam-7218	552	88	department	department	NOUN
bam-7218	552	89	of	of	ADP
bam-7218	552	90	public	public	ADJ
bam-7218	552	91	health	health	NOUN
bam-7218	552	92	sport	sport	NOUN
bam-7218	552	93	science	science	NOUN
bam-7218	552	94	,	,	PUNCT
bam-7218	552	95	aarhus	aarhus	PROPN
bam-7218	552	96	university	university	PROPN
bam-7218	552	97	,	,	PUNCT
bam-7218	552	98	denmark	denmark	NOUN
bam-7218	552	99	)	)	PUNCT
bam-7218	552	100	–	–	PUNCT
bam-7218	552	101	(	(	PUNCT
bam-7218	552	102	e	e	NOUN
bam-7218	552	103	)	)	PUNCT
bam-7218	552	104	university	university	NOUN
bam-7218	552	105	of	of	ADP
bam-7218	552	106	cologne	cologne	NOUN
bam-7218	552	107	,	,	PUNCT
bam-7218	552	108	germany	germany	PROPN
bam-7218	552	109	e	e	PROPN
bam-7218	552	110	-	-	NOUN
bam-7218	552	111	mail	mail	NOUN
bam-7218	552	112	:	:	PUNCT
bam-7218	552	113	leonardo.nogara@unipd.it	leonardo.nogara@unipd.it	PROPN
bam-7218	552	114	gene	gene	NOUN
bam-7218	552	115	transcription	transcription	NOUN
bam-7218	552	116	is	be	AUX
bam-7218	552	117	strongly	strongly	ADV
bam-7218	552	118	influenced	influence	VERB
bam-7218	552	119	by	by	ADP
bam-7218	552	120	various	various	ADJ
bam-7218	552	121	posttranslational	posttranslational	ADJ
bam-7218	552	122	modifications	modification	NOUN
bam-7218	552	123	of	of	ADP
bam-7218	552	124	the	the	DET
bam-7218	552	125	n	n	CCONJ
bam-7218	552	126	-	-	PUNCT
bam-7218	552	127	terminal	terminal	ADJ
bam-7218	552	128	tails	tail	NOUN
bam-7218	552	129	of	of	ADP
bam-7218	552	130	histones	histone	NOUN
bam-7218	552	131	.	.	PUNCT
bam-7218	553	1	the	the	DET
bam-7218	553	2	aim	aim	NOUN
bam-7218	553	3	of	of	ADP
bam-7218	553	4	our	our	PRON
bam-7218	553	5	study	study	NOUN
bam-7218	553	6	is	be	AUX
bam-7218	553	7	to	to	PART
bam-7218	553	8	understand	understand	VERB
bam-7218	553	9	which	which	DET
bam-7218	553	10	role	role	NOUN
bam-7218	553	11	histone	histone	NOUN
bam-7218	553	12	modifications	modification	NOUN
bam-7218	553	13	play	play	VERB
bam-7218	553	14	during	during	ADP
bam-7218	553	15	exercise	exercise	NOUN
bam-7218	553	16	-	-	PUNCT
bam-7218	553	17	induced	induce	VERB
bam-7218	553	18	chromatin	chromatin	NOUN
bam-7218	553	19	remodelling	remodelling	NOUN
bam-7218	553	20	in	in	ADP
bam-7218	553	21	skeletal	skeletal	ADJ
bam-7218	553	22	muscle	muscle	NOUN
bam-7218	553	23	.	.	PUNCT
bam-7218	554	1	in	in	ADP
bam-7218	554	2	our	our	PRON
bam-7218	554	3	analyses	analysis	NOUN
bam-7218	554	4	,	,	PUNCT
bam-7218	554	5	we	we	PRON
bam-7218	554	6	found	find	VERB
bam-7218	554	7	a	a	DET
bam-7218	554	8	rapid	rapid	ADJ
bam-7218	554	9	and	and	CCONJ
bam-7218	554	10	significant	significant	ADJ
bam-7218	554	11	increase	increase	NOUN
bam-7218	554	12	in	in	ADP
bam-7218	554	13	phosphorylation	phosphorylation	NOUN
bam-7218	554	14	of	of	ADP
bam-7218	554	15	histone	histone	NOUN
bam-7218	554	16	3	3	NUM
bam-7218	554	17	on	on	ADP
bam-7218	554	18	serine	serine	NOUN
bam-7218	554	19	10	10	NUM
bam-7218	554	20	after	after	ADP
bam-7218	554	21	eccentric	eccentric	ADJ
bam-7218	554	22	contractions	contraction	NOUN
bam-7218	554	23	.	.	PUNCT
bam-7218	555	1	moreover	moreover	ADV
bam-7218	555	2	,	,	PUNCT
bam-7218	555	3	we	we	PRON
bam-7218	555	4	have	have	AUX
bam-7218	555	5	found	find	VERB
bam-7218	555	6	that	that	SCONJ
bam-7218	555	7	this	this	DET
bam-7218	555	8	histone	histone	NOUN
bam-7218	555	9	phosphorylation	phosphorylation	NOUN
bam-7218	555	10	is	be	AUX
bam-7218	555	11	followed	follow	VERB
bam-7218	555	12	by	by	ADP
bam-7218	555	13	an	an	DET
bam-7218	555	14	increase	increase	NOUN
bam-7218	555	15	in	in	ADP
bam-7218	555	16	the	the	DET
bam-7218	555	17	acetylation	acetylation	NOUN
bam-7218	555	18	of	of	ADP
bam-7218	555	19	the	the	DET
bam-7218	555	20	nearby	nearby	ADJ
bam-7218	555	21	lysine	lysine	NOUN
bam-7218	555	22	14	14	NUM
bam-7218	555	23	,	,	PUNCT
bam-7218	555	24	suggestive	suggestive	ADJ
bam-7218	555	25	of	of	ADP
bam-7218	555	26	an	an	DET
bam-7218	555	27	activation	activation	NOUN
bam-7218	555	28	of	of	ADP
bam-7218	555	29	gene	gene	NOUN
bam-7218	555	30	transcription	transcription	NOUN
bam-7218	555	31	.	.	PUNCT
bam-7218	556	1	we	we	PRON
bam-7218	556	2	identified	identify	VERB
bam-7218	556	3	p38	p38	NOUN
bam-7218	556	4	-	-	PUNCT
bam-7218	556	5	msk1	msk1	NOUN
bam-7218	556	6	,	,	PUNCT
bam-7218	556	7	whose	whose	DET
bam-7218	556	8	activity	activity	NOUN
bam-7218	556	9	is	be	AUX
bam-7218	556	10	strongly	strongly	ADV
bam-7218	556	11	up	up	ADP
bam-7218	556	12	regulated	regulate	VERB
bam-7218	556	13	during	during	ADP
bam-7218	556	14	exercise	exercise	NOUN
bam-7218	556	15	in	in	ADP
bam-7218	556	16	muscles	muscle	NOUN
bam-7218	556	17	,	,	PUNCT
bam-7218	556	18	as	as	SCONJ
bam-7218	556	19	the	the	DET
bam-7218	556	20	kinase	kinase	NOUN
bam-7218	556	21	involved	involve	VERB
bam-7218	556	22	in	in	ADP
bam-7218	556	23	this	this	DET
bam-7218	556	24	phosphorylation	phosphorylation	NOUN
bam-7218	556	25	.	.	PUNCT
bam-7218	557	1	we	we	PRON
bam-7218	557	2	are	be	AUX
bam-7218	557	3	now	now	ADV
bam-7218	557	4	investigating	investigate	VERB
bam-7218	557	5	the	the	DET
bam-7218	557	6	upstream	upstream	ADJ
bam-7218	557	7	signals	signal	NOUN
bam-7218	557	8	responsible	responsible	ADJ
bam-7218	557	9	for	for	ADP
bam-7218	557	10	p38mks1	p38mks1	ADJ
bam-7218	557	11	activation	activation	NOUN
bam-7218	557	12	and	and	CCONJ
bam-7218	557	13	the	the	DET
bam-7218	557	14	histone	histone	NOUN
bam-7218	557	15	modifications	modification	NOUN
bam-7218	557	16	observed	observe	VERB
bam-7218	557	17	.	.	PUNCT
bam-7218	558	1	in	in	ADP
bam-7218	558	2	addition	addition	NOUN
bam-7218	558	3	to	to	ADP
bam-7218	558	4	our	our	PRON
bam-7218	558	5	results	result	NOUN
bam-7218	558	6	in	in	ADP
bam-7218	558	7	mice	mouse	NOUN
bam-7218	558	8	,	,	PUNCT
bam-7218	558	9	we	we	PRON
bam-7218	558	10	confirmed	confirm	VERB
bam-7218	558	11	our	our	PRON
bam-7218	558	12	results	result	NOUN
bam-7218	558	13	in	in	ADP
bam-7218	558	14	human	human	ADJ
bam-7218	558	15	biopsies	biopsy	NOUN
bam-7218	558	16	taken	take	VERB
bam-7218	558	17	immediately	immediately	ADV
bam-7218	558	18	after	after	ADP
bam-7218	558	19	high	high	ADJ
bam-7218	558	20	intensity	intensity	NOUN
bam-7218	558	21	exercise	exercise	NOUN
bam-7218	558	22	where	where	SCONJ
bam-7218	558	23	we	we	PRON
bam-7218	558	24	have	have	AUX
bam-7218	558	25	observed	observe	VERB
bam-7218	558	26	similar	similar	ADJ
bam-7218	558	27	changes	change	NOUN
bam-7218	558	28	in	in	ADP
bam-7218	558	29	signaling	signal	VERB
bam-7218	558	30	and	and	CCONJ
bam-7218	558	31	histone	histone	NOUN
bam-7218	558	32	phosphorylation	phosphorylation	NOUN
bam-7218	558	33	.	.	PUNCT
bam-7218	559	1	in	in	ADP
bam-7218	559	2	our	our	PRON
bam-7218	559	3	model	model	NOUN
bam-7218	559	4	of	of	ADP
bam-7218	559	5	exercise	exercise	NOUN
bam-7218	559	6	,	,	PUNCT
bam-7218	559	7	the	the	DET
bam-7218	559	8	activation	activation	NOUN
bam-7218	559	9	of	of	ADP
bam-7218	559	10	the	the	DET
bam-7218	559	11	early	early	ADJ
bam-7218	559	12	genes	gene	NOUN
bam-7218	559	13	fos	fos	VERB
bam-7218	559	14	,	,	PUNCT
bam-7218	559	15	jun	jun	PROPN
bam-7218	559	16	and	and	CCONJ
bam-7218	559	17	egr1	egr1	PROPN
bam-7218	559	18	have	have	AUX
bam-7218	559	19	been	be	AUX
bam-7218	559	20	confirmed	confirm	VERB
bam-7218	559	21	by	by	ADP
bam-7218	559	22	chip	chip	NOUN
bam-7218	559	23	analyses	analysis	NOUN
bam-7218	559	24	on	on	ADP
bam-7218	559	25	the	the	DET
bam-7218	559	26	phosphorylated	phosphorylate	VERB
bam-7218	559	27	histone	histone	NOUN
bam-7218	559	28	.	.	PUNCT
bam-7218	560	1	we	we	PRON
bam-7218	560	2	are	be	AUX
bam-7218	560	3	now	now	ADV
bam-7218	560	4	exploring	explore	VERB
bam-7218	560	5	the	the	DET
bam-7218	560	6	expression	expression	NOUN
bam-7218	560	7	of	of	ADP
bam-7218	560	8	immediate	immediate	ADJ
bam-7218	560	9	early	early	ADJ
bam-7218	560	10	genes	gene	NOUN
bam-7218	560	11	in	in	ADP
bam-7218	560	12	msk1/2	msk1/2	PROPN
bam-7218	560	13	ko	ko	NOUN
bam-7218	560	14	mice	mouse	NOUN
bam-7218	560	15	to	to	PART
bam-7218	560	16	understand	understand	VERB
bam-7218	560	17	the	the	DET
bam-7218	560	18	importance	importance	NOUN
bam-7218	560	19	of	of	ADP
bam-7218	560	20	histone	histone	NOUN
bam-7218	560	21	phosphorylation	phosphorylation	NOUN
bam-7218	560	22	in	in	ADP
bam-7218	560	23	the	the	DET
bam-7218	560	24	early	early	ADJ
bam-7218	560	25	gene	gene	NOUN
bam-7218	560	26	response	response	NOUN
bam-7218	560	27	to	to	PART
bam-7218	560	28	exercise	exercise	VERB
bam-7218	560	29	.	.	PUNCT
bam-7218	561	1	5.3	5.3	NUM
bam-7218	561	2	the	the	DET
bam-7218	561	3	differentiation	differentiation	NOUN
bam-7218	561	4	of	of	ADP
bam-7218	561	5	fibro	fibro	PROPN
bam-7218	561	6	adipogenic	adipogenic	ADJ
bam-7218	561	7	progenitors	progenitor	NOUN
bam-7218	561	8	of	of	ADP
bam-7218	561	9	a	a	DET
bam-7218	561	10	mouse	mouse	NOUN
bam-7218	561	11	model	model	NOUN
bam-7218	561	12	of	of	ADP
bam-7218	561	13	duchenne	duchenne	PROPN
bam-7218	561	14	muscular	muscular	ADJ
bam-7218	561	15	dystrophy	dystrophy	NOUN
bam-7218	561	16	is	be	AUX
bam-7218	561	17	insensitive	insensitive	ADJ
bam-7218	561	18	to	to	ADP
bam-7218	561	19	negative	negative	ADJ
bam-7218	561	20	regulation	regulation	NOUN
bam-7218	561	21	by	by	ADP
bam-7218	561	22	notch	notch	PROPN
bam-7218	561	23	milica	milica	PROPN
bam-7218	561	24	marinkovic	marinkovic	PROPN
bam-7218	561	25	(	(	PUNCT
bam-7218	561	26	a	a	NOUN
bam-7218	561	27	)	)	PUNCT
bam-7218	561	28	,	,	PUNCT
bam-7218	561	29	lucia	lucia	PROPN
bam-7218	561	30	lisa	lisa	PROPN
bam-7218	561	31	petrilli	petrilli	PROPN
bam-7218	561	32	(	(	PUNCT
bam-7218	561	33	a	a	PROPN
bam-7218	561	34	)	)	PUNCT
bam-7218	561	35	,	,	PUNCT
bam-7218	561	36	filomena	filomena	PROPN
bam-7218	561	37	spada	spada	PROPN
bam-7218	561	38	(	(	PUNCT
bam-7218	561	39	a	a	NOUN
bam-7218	561	40	)	)	PUNCT
bam-7218	561	41	,	,	PUNCT
bam-7218	561	42	francesca	francesca	PROPN
bam-7218	561	43	sacco	sacco	PROPN
bam-7218	561	44	(	(	PUNCT
bam-7218	561	45	2	2	NUM
bam-7218	561	46	)	)	PUNCT
bam-7218	561	47	,	,	PUNCT
bam-7218	561	48	marco	marco	PROPN
bam-7218	561	49	rosina	rosina	PROPN
bam-7218	561	50	(	(	PUNCT
bam-7218	561	51	a	a	PROPN
bam-7218	561	52	)	)	PUNCT
bam-7218	561	53	,	,	PUNCT
bam-7218	561	54	claudia	claudia	NOUN
bam-7218	561	55	fuoco	fuoco	NOUN
bam-7218	561	56	(	(	PUNCT
bam-7218	561	57	a	a	NOUN
bam-7218	561	58	)	)	PUNCT
bam-7218	561	59	,	,	PUNCT
bam-7218	561	60	matthias	matthias	PROPN
bam-7218	561	61	mann	mann	X
bam-7218	561	62	(	(	PUNCT
bam-7218	561	63	b	b	NOUN
bam-7218	561	64	)	)	PUNCT
bam-7218	561	65	,	,	PUNCT
bam-7218	561	66	luisa	luisa	PROPN
bam-7218	561	67	castagnoli	castagnoli	NOUN
bam-7218	561	68	(	(	PUNCT
bam-7218	561	69	a	a	X
bam-7218	561	70	)	)	PUNCT
bam-7218	561	71	,	,	PUNCT
bam-7218	561	72	cesare	cesare	PROPN
bam-7218	561	73	gargioli	gargioli	PROPN
bam-7218	561	74	(	(	PUNCT
bam-7218	561	75	a	a	X
bam-7218	561	76	)	)	PUNCT
bam-7218	561	77	,	,	PUNCT
bam-7218	561	78	gianni	gianni	PROPN
bam-7218	561	79	cesareni	cesareni	PROPN
bam-7218	561	80	(	(	PUNCT
bam-7218	561	81	a	a	NOUN
bam-7218	561	82	)	)	PUNCT
bam-7218	561	83	(	(	PUNCT
bam-7218	561	84	a	a	X
bam-7218	561	85	)	)	PUNCT
bam-7218	561	86	dept	dept	NOUN
bam-7218	561	87	of	of	ADP
bam-7218	561	88	biology	biology	NOUN
bam-7218	561	89	,	,	PUNCT
bam-7218	561	90	university	university	NOUN
bam-7218	561	91	of	of	ADP
bam-7218	561	92	rome	rome	PROPN
bam-7218	561	93	tor	tor	PROPN
bam-7218	561	94	vergata	vergata	PROPN
bam-7218	561	95	,	,	PUNCT
bam-7218	561	96	italy	italy	PROPN
bam-7218	561	97	;	;	PUNCT
bam-7218	561	98	(	(	PUNCT
bam-7218	561	99	b	b	X
bam-7218	561	100	)	)	PUNCT
bam-7218	561	101	dept	dept	NOUN
bam-7218	561	102	of	of	ADP
bam-7218	561	103	proteomics	proteomic	NOUN
bam-7218	561	104	and	and	CCONJ
bam-7218	561	105	signal	signal	ADJ
bam-7218	561	106	transduction	transduction	NOUN
bam-7218	561	107	,	,	PUNCT
bam-7218	561	108	max	max	PROPN
bam-7218	561	109	-	-	PUNCT
bam-7218	561	110	planck	planck	PROPN
bam-7218	561	111	institute	institute	PROPN
bam-7218	561	112	of	of	ADP
bam-7218	561	113	biochemistry	biochemistry	PROPN
bam-7218	561	114	,	,	PUNCT
bam-7218	561	115	martinsried	martinsried	ADJ
bam-7218	561	116	,	,	PUNCT
bam-7218	561	117	germany	germany	PROPN
bam-7218	561	118	.	.	PUNCT
bam-7218	562	1	e	e	X
bam-7218	562	2	-	-	NOUN
bam-7218	562	3	mail	mail	NOUN
bam-7218	562	4	:	:	PUNCT
bam-7218	562	5	cesareni@uniroma2.it	cesareni@uniroma2.it	PROPN
bam-7218	562	6	fibro	fibro	PROPN
bam-7218	562	7	adipogenic	adipogenic	ADJ
bam-7218	562	8	progenitors	progenitor	NOUN
bam-7218	562	9	(	(	PUNCT
bam-7218	562	10	faps	fap	NOUN
bam-7218	562	11	)	)	PUNCT
bam-7218	562	12	play	play	VERB
bam-7218	562	13	a	a	DET
bam-7218	562	14	leading	lead	VERB
bam-7218	562	15	role	role	NOUN
bam-7218	562	16	in	in	ADP
bam-7218	562	17	muscle	muscle	NOUN
bam-7218	562	18	regeneration	regeneration	NOUN
bam-7218	562	19	by	by	ADP
bam-7218	562	20	positively	positively	ADV
bam-7218	562	21	regulating	regulate	VERB
bam-7218	562	22	satellite	satellite	NOUN
bam-7218	562	23	cells	cell	NOUN
bam-7218	562	24	differentiation	differentiation	NOUN
bam-7218	562	25	.	.	PUNCT
bam-7218	563	1	however	however	ADV
bam-7218	563	2	,	,	PUNCT
bam-7218	563	3	in	in	ADP
bam-7218	563	4	pathological	pathological	ADJ
bam-7218	563	5	conditions	condition	NOUN
bam-7218	563	6	,	,	PUNCT
bam-7218	563	7	they	they	PRON
bam-7218	563	8	are	be	AUX
bam-7218	563	9	responsible	responsible	ADJ
bam-7218	563	10	for	for	ADP
bam-7218	563	11	fibrosis	fibrosis	NOUN
bam-7218	563	12	and	and	CCONJ
bam-7218	563	13	fat	fat	ADJ
bam-7218	563	14	infiltration	infiltration	NOUN
bam-7218	563	15	.	.	PUNCT
bam-7218	564	1	despite	despite	SCONJ
bam-7218	564	2	the	the	DET
bam-7218	564	3	established	establish	VERB
bam-7218	564	4	importance	importance	NOUN
bam-7218	564	5	of	of	ADP
bam-7218	564	6	faps	fap	NOUN
bam-7218	564	7	in	in	ADP
bam-7218	564	8	both	both	DET
bam-7218	564	9	regeneration	regeneration	NOUN
bam-7218	564	10	and	and	CCONJ
bam-7218	564	11	degeneration	degeneration	NOUN
bam-7218	564	12	,	,	PUNCT
bam-7218	564	13	the	the	DET
bam-7218	564	14	signals	signal	NOUN
bam-7218	564	15	that	that	PRON
bam-7218	564	16	regulate	regulate	VERB
bam-7218	564	17	these	these	DET
bam-7218	564	18	opposing	oppose	VERB
bam-7218	564	19	roles	role	NOUN
bam-7218	564	20	are	be	AUX
bam-7218	564	21	not	not	PART
bam-7218	564	22	fully	fully	ADV
bam-7218	564	23	characterized	characterize	VERB
bam-7218	564	24	.	.	PUNCT
bam-7218	565	1	our	our	PRON
bam-7218	565	2	results	result	NOUN
bam-7218	565	3	support	support	VERB
bam-7218	565	4	a	a	DET
bam-7218	565	5	model	model	NOUN
bam-7218	565	6	whereby	whereby	SCONJ
bam-7218	565	7	notch	notch	NOUN
bam-7218	565	8	plays	play	VERB
bam-7218	565	9	an	an	DET
bam-7218	565	10	important	important	ADJ
bam-7218	565	11	role	role	NOUN
bam-7218	565	12	in	in	ADP
bam-7218	565	13	the	the	DET
bam-7218	565	14	regulation	regulation	NOUN
bam-7218	565	15	of	of	ADP
bam-7218	565	16	fap	fap	NOUN
bam-7218	565	17	differentiation	differentiation	NOUN
bam-7218	565	18	.	.	PUNCT
bam-7218	566	1	in	in	ADP
bam-7218	566	2	addition	addition	NOUN
bam-7218	566	3	,	,	PUNCT
bam-7218	566	4	when	when	SCONJ
bam-7218	566	5	co	co	VERB
bam-7218	566	6	-	-	ADJ
bam-7218	566	7	cultured	cultured	ADJ
bam-7218	566	8	ex	ex	X
bam-7218	566	9	vivo	vivo	NOUN
bam-7218	566	10	,	,	PUNCT
bam-7218	566	11	myotubes	myotube	NOUN
bam-7218	566	12	inhibits	inhibit	VERB
bam-7218	566	13	the	the	DET
bam-7218	566	14	adipogenic	adipogenic	ADJ
bam-7218	566	15	differentiation	differentiation	NOUN
bam-7218	566	16	of	of	ADP
bam-7218	566	17	faps	fap	NOUN
bam-7218	566	18	in	in	ADP
bam-7218	566	19	a	a	DET
bam-7218	566	20	notch	notch	ADJ
bam-7218	566	21	dependent	dependent	ADJ
bam-7218	566	22	way	way	NOUN
bam-7218	566	23	.	.	PUNCT
bam-7218	567	1	interestingly	interestingly	ADV
bam-7218	567	2	,	,	PUNCT
bam-7218	567	3	this	this	DET
bam-7218	567	4	control	control	NOUN
bam-7218	567	5	mechanism	mechanism	NOUN
bam-7218	567	6	is	be	AUX
bam-7218	567	7	impaired	impair	VERB
bam-7218	567	8	in	in	ADP
bam-7218	567	9	faps	fap	NOUN
bam-7218	567	10	isolated	isolate	VERB
bam-7218	567	11	from	from	ADP
bam-7218	567	12	young	young	ADJ
bam-7218	567	13	dystrophin	dystrophin	NOUN
bam-7218	567	14	-	-	PUNCT
bam-7218	567	15	deficient	deficient	ADJ
bam-7218	567	16	(	(	PUNCT
bam-7218	567	17	mdx	mdx	NOUN
bam-7218	567	18	)	)	PUNCT
bam-7218	567	19	mice	mouse	NOUN
bam-7218	567	20	or	or	CCONJ
bam-7218	567	21	in	in	ADP
bam-7218	567	22	faps	fap	NOUN
bam-7218	567	23	from	from	ADP
bam-7218	567	24	ageing	age	VERB
bam-7218	567	25	wild	wild	ADJ
bam-7218	567	26	type	type	NOUN
bam-7218	567	27	mice	mouse	NOUN
bam-7218	567	28	.	.	PUNCT
bam-7218	568	1	to	to	PART
bam-7218	568	2	further	far	ADV
bam-7218	568	3	investigate	investigate	VERB
bam-7218	568	4	these	these	DET
bam-7218	568	5	phenotypic	phenotypic	ADJ
bam-7218	568	6	differences	difference	NOUN
bam-7218	568	7	,	,	PUNCT
bam-7218	568	8	we	we	PRON
bam-7218	568	9	performed	perform	VERB
bam-7218	568	10	deep	deep	ADJ
bam-7218	568	11	proteomics	proteomic	NOUN
bam-7218	568	12	profiling	profiling	NOUN
bam-7218	568	13	and	and	CCONJ
bam-7218	568	14	multiparametric	multiparametric	ADJ
bam-7218	568	15	analyses	analysis	NOUN
bam-7218	568	16	of	of	ADP
bam-7218	568	17	mdx	mdx	NOUN
bam-7218	568	18	and	and	CCONJ
bam-7218	568	19	wild	wild	ADJ
bam-7218	568	20	type	type	NOUN
bam-7218	568	21	faps	fap	NOUN
bam-7218	568	22	,	,	PUNCT
bam-7218	568	23	by	by	ADP
bam-7218	568	24	exploiting	exploit	VERB
bam-7218	568	25	single	single	ADJ
bam-7218	568	26	cell	cell	NOUN
bam-7218	568	27	mass	mass	NOUN
bam-7218	568	28	cytometry	cytometry	NOUN
bam-7218	568	29	and	and	CCONJ
bam-7218	568	30	mass	mass	ADJ
bam-7218	568	31	spectrometry	spectrometry	NOUN
bam-7218	568	32	based	base	VERB
bam-7218	568	33	proteomics	proteomic	NOUN
bam-7218	568	34	.	.	PUNCT
bam-7218	569	1	both	both	DET
bam-7218	569	2	analyses	analysis	NOUN
bam-7218	569	3	reveal	reveal	VERB
bam-7218	569	4	clear	clear	ADJ
bam-7218	569	5	differences	difference	NOUN
bam-7218	569	6	in	in	ADP
bam-7218	569	7	the	the	DET
bam-7218	569	8	phenotypes	phenotype	NOUN
bam-7218	569	9	of	of	ADP
bam-7218	569	10	the	the	DET
bam-7218	569	11	mdx	mdx	NOUN
bam-7218	569	12	and	and	CCONJ
bam-7218	569	13	wild	wild	ADJ
bam-7218	569	14	type	type	NOUN
bam-7218	569	15	cell	cell	NOUN
bam-7218	569	16	populations	population	NOUN
bam-7218	569	17	and	and	CCONJ
bam-7218	569	18	in	in	ADP
bam-7218	569	19	their	their	PRON
bam-7218	569	20	proteome	proteome	ADJ
bam-7218	569	21	profiles	profile	NOUN
bam-7218	569	22	.	.	PUNCT
bam-7218	570	1	significantly	significantly	ADV
bam-7218	570	2	we	we	PRON
bam-7218	570	3	observed	observe	VERB
bam-7218	570	4	a	a	DET
bam-7218	570	5	striking	striking	ADJ
bam-7218	570	6	perturbation	perturbation	NOUN
bam-7218	570	7	of	of	ADP
bam-7218	570	8	the	the	DET
bam-7218	570	9	concentration	concentration	NOUN
bam-7218	570	10	level	level	NOUN
bam-7218	570	11	of	of	ADP
bam-7218	570	12	metabolic	metabolic	NOUN
bam-7218	570	13	enzymes	enzyme	NOUN
bam-7218	570	14	where	where	SCONJ
bam-7218	570	15	a	a	DET
bam-7218	570	16	significant	significant	ADJ
bam-7218	570	17	decrease	decrease	NOUN
bam-7218	570	18	of	of	ADP
bam-7218	570	19	enzymes	enzyme	NOUN
bam-7218	570	20	of	of	ADP
bam-7218	570	21	the	the	DET
bam-7218	570	22	tca	tca	PROPN
bam-7218	570	23	cycle	cycle	NOUN
bam-7218	570	24	and	and	CCONJ
bam-7218	570	25	fatty	fatty	NOUN
bam-7218	570	26	acid	acid	NOUN
bam-7218	570	27	oxidation	oxidation	NOUN
bam-7218	570	28	pathway	pathway	NOUN
bam-7218	570	29	was	be	AUX
bam-7218	570	30	balanced	balance	VERB
bam-7218	570	31	by	by	ADP
bam-7218	570	32	an	an	DET
bam-7218	570	33	increase	increase	NOUN
bam-7218	570	34	of	of	ADP
bam-7218	570	35	the	the	DET
bam-7218	570	36	enzymes	enzyme	NOUN
bam-7218	570	37	of	of	ADP
bam-7218	570	38	the	the	DET
bam-7218	570	39	glycolytic	glycolytic	ADJ
bam-7218	570	40	pathway	pathway	NOUN
bam-7218	570	41	.	.	PUNCT
bam-7218	571	1	in	in	ADP
bam-7218	571	2	addition	addition	NOUN
bam-7218	571	3	an	an	DET
bam-7218	571	4	increase	increase	NOUN
bam-7218	571	5	in	in	ADP
bam-7218	571	6	proteins	protein	NOUN
bam-7218	571	7	involved	involve	VERB
bam-7218	571	8	in	in	ADP
bam-7218	571	9	exosome	exosome	ADJ
bam-7218	571	10	formation	formation	NOUN
bam-7218	571	11	or	or	CCONJ
bam-7218	571	12	in	in	ADP
bam-7218	571	13	response	response	NOUN
bam-7218	571	14	to	to	ADP
bam-7218	571	15	activation	activation	NOUN
bam-7218	571	16	of	of	ADP
bam-7218	571	17	tollike	tollike	ADJ
bam-7218	571	18	receptors	receptor	NOUN
bam-7218	571	19	was	be	AUX
bam-7218	571	20	also	also	ADV
bam-7218	571	21	observed	observe	VERB
bam-7218	571	22	.	.	PUNCT
bam-7218	572	1	5.4	5.4	NUM
bam-7218	572	2	lamin	lamin	NOUN
bam-7218	572	3	a	a	PRON
bam-7218	572	4	/	/	SYM
bam-7218	572	5	c	c	NOUN
bam-7218	572	6	is	be	AUX
bam-7218	572	7	crucial	crucial	ADJ
bam-7218	572	8	for	for	ADP
bam-7218	572	9	skeletal	skeletal	ADJ
bam-7218	572	10	muscle	muscle	NOUN
bam-7218	572	11	plasticity	plasticity	NOUN
bam-7218	572	12	daniel	daniel	PROPN
bam-7218	572	13	owens	owens	PROPN
bam-7218	572	14	,	,	PUNCT
bam-7218	572	15	julien	julien	PROPN
bam-7218	572	16	mésséant	mésséant	PROPN
bam-7218	572	17	,	,	PUNCT
bam-7218	572	18	gaelle	gaelle	NOUN
bam-7218	572	19	herledan	herledan	PROPN
bam-7218	572	20	,	,	PUNCT
bam-7218	572	21	arnaud	arnaud	PROPN
bam-7218	572	22	ferry	ferry	NOUN
bam-7218	572	23	,	,	PUNCT
bam-7218	572	24	anne	anne	PROPN
bam-7218	572	25	bertrand	bertrand	PROPN
bam-7218	572	26	,	,	PUNCT
bam-7218	572	27	gisèle	gisèle	PROPN
bam-7218	572	28	bonne	bonne	PROPN
bam-7218	572	29	,	,	PUNCT
bam-7218	572	30	catherine	catherine	PROPN
bam-7218	572	31	coirault	coirault	PROPN
bam-7218	572	32	inserm	inserm	NOUN
bam-7218	572	33	umrs	umrs	ADJ
bam-7218	572	34	974	974	NUM
bam-7218	572	35	,	,	PUNCT
bam-7218	572	36	sorbonne	sorbonne	PROPN
bam-7218	572	37	université	université	PROPN
bam-7218	572	38	,	,	PUNCT
bam-7218	572	39	institut	institut	PROPN
bam-7218	572	40	de	de	PROPN
bam-7218	572	41	myologie	myologie	PROPN
bam-7218	572	42	,	,	PUNCT
bam-7218	572	43	france	france	PROPN
bam-7218	572	44	.	.	PUNCT
bam-7218	573	1	e	e	X
bam-7218	573	2	-	-	NOUN
bam-7218	573	3	mail	mail	NOUN
bam-7218	573	4	:	:	PUNCT
bam-7218	573	5	catherine.coirault@inserm.fr	catherine.coirault@inserm.fr	NOUN
bam-7218	573	6	mutations	mutation	NOUN
bam-7218	573	7	in	in	ADP
bam-7218	573	8	the	the	DET
bam-7218	573	9	lmna	lmna	NOUN
bam-7218	573	10	gene	gene	NOUN
bam-7218	573	11	encoding	encode	VERB
bam-7218	573	12	the	the	DET
bam-7218	573	13	nuclear	nuclear	ADJ
bam-7218	573	14	lamins	lamin	NOUN
bam-7218	573	15	a	a	DET
bam-7218	573	16	/	/	SYM
bam-7218	573	17	c	c	NOUN
bam-7218	573	18	cause	cause	VERB
bam-7218	573	19	a	a	DET
bam-7218	573	20	variety	variety	NOUN
bam-7218	573	21	of	of	ADP
bam-7218	573	22	diseases	disease	NOUN
bam-7218	573	23	,	,	PUNCT
bam-7218	573	24	including	include	VERB
bam-7218	573	25	laminrelated	laminrelate	VERB
bam-7218	573	26	congenital	congenital	ADJ
bam-7218	573	27	muscle	muscle	NOUN
bam-7218	573	28	dystrophy	dystrophy	NOUN
bam-7218	573	29	(	(	PUNCT
bam-7218	573	30	l	l	NOUN
bam-7218	573	31	-	-	PUNCT
bam-7218	573	32	cmd	cmd	NOUN
bam-7218	573	33	)	)	PUNCT
bam-7218	573	34	.	.	PUNCT
bam-7218	574	1	the	the	DET
bam-7218	574	2	underlying	underlie	VERB
bam-7218	574	3	mechanisms	mechanism	NOUN
bam-7218	574	4	by	by	ADP
bam-7218	574	5	which	which	PRON
bam-7218	574	6	lmna	lmna	VERB
bam-7218	574	7	mutations	mutation	NOUN
bam-7218	574	8	cause	cause	VERB
bam-7218	574	9	tissue	tissue	NOUN
bam-7218	574	10	specific	specific	ADJ
bam-7218	574	11	disease	disease	NOUN
bam-7218	574	12	remain	remain	VERB
bam-7218	574	13	elusive	elusive	ADJ
bam-7218	574	14	.	.	PUNCT
bam-7218	575	1	given	give	VERB
bam-7218	575	2	the	the	DET
bam-7218	575	3	apparent	apparent	ADJ
bam-7218	575	4	contribution	contribution	NOUN
bam-7218	575	5	of	of	ADP
bam-7218	575	6	lamins	lamin	NOUN
bam-7218	575	7	a	a	DET
bam-7218	575	8	/	/	SYM
bam-7218	575	9	c	c	NOUN
bam-7218	575	10	to	to	ADP
bam-7218	575	11	cellular	cellular	ADJ
bam-7218	575	12	mechanotransduction	mechanotransduction	NOUN
bam-7218	575	13	,	,	PUNCT
bam-7218	575	14	we	we	PRON
bam-7218	575	15	hypothesized	hypothesize	VERB
bam-7218	575	16	that	that	SCONJ
bam-7218	575	17	defective	defective	ADJ
bam-7218	575	18	mechanical	mechanical	ADJ
bam-7218	575	19	properties	property	NOUN
bam-7218	575	20	of	of	ADP
bam-7218	575	21	lmna	lmna	NOUN
bam-7218	575	22	mutated	mutate	VERB
bam-7218	575	23	muscle	muscle	NOUN
bam-7218	575	24	mailto:leonardo.nogara@unipd.it	mailto:leonardo.nogara@unipd.it	PROPN
bam-7218	575	25	mailto:cesareni@uniroma2.it	mailto:cesareni@uniroma2.it	PROPN
bam-7218	575	26	mailto:catherine.coirault@inserm.fr	mailto:catherine.coirault@inserm.fr	NOUN
bam-7218	575	27	14	14	NUM
bam-7218	575	28	th	th	NOUN
bam-7218	575	29	iiim	iiim	NOUN
bam-7218	575	30	meeting	meeting	NOUN
bam-7218	575	31	,	,	PUNCT
bam-7218	575	32	assisi	assisi	PROPN
bam-7218	575	33	,	,	PUNCT
bam-7218	575	34	italy	italy	PROPN
bam-7218	575	35	october	october	PROPN
bam-7218	575	36	12	12	NUM
bam-7218	575	37	-	-	SYM
bam-7218	575	38	15	15	NUM
bam-7218	575	39	2017	2017	NUM
bam-7218	575	40	eur	eur	PROPN
bam-7218	575	41	j	j	PROPN
bam-7218	575	42	transl	transl	PROPN
bam-7218	575	43	myol	myol	ADV
bam-7218	575	44	27	27	NUM
bam-7218	575	45	(	(	PUNCT
bam-7218	575	46	4	4	NUM
bam-7218	575	47	):	):	SYM
bam-7218	575	48	185	185	NUM
bam-7218	575	49	-	-	SYM
bam-7218	575	50	224	224	NUM
bam-7218	575	51	202	202	NUM
bam-7218	575	52	contribute	contribute	VERB
bam-7218	575	53	to	to	ADP
bam-7218	575	54	the	the	DET
bam-7218	575	55	dystrophic	dystrophic	ADJ
bam-7218	575	56	phenotype	phenotype	NOUN
bam-7218	575	57	in	in	ADP
bam-7218	575	58	l-cmd.to	l-cmd.to	PUNCT
bam-7218	575	59	assess	assess	NOUN
bam-7218	575	60	muscle	muscle	NOUN
bam-7218	575	61	plasticity	plasticity	NOUN
bam-7218	575	62	,	,	PUNCT
bam-7218	575	63	plantaris	plantaris	NOUN
bam-7218	575	64	muscle	muscle	NOUN
bam-7218	575	65	(	(	PUNCT
bam-7218	575	66	pln	pln	PROPN
bam-7218	575	67	)	)	PUNCT
bam-7218	575	68	of	of	ADP
bam-7218	575	69	wt	wt	ADP
bam-7218	575	70	and	and	CCONJ
bam-7218	575	71	lmna+/δk32	lmna+/δk32	NOUN
bam-7218	575	72	mice	mouse	NOUN
bam-7218	575	73	were	be	AUX
bam-7218	575	74	mechanically	mechanically	ADV
bam-7218	575	75	overloaded	overload	VERB
bam-7218	575	76	by	by	ADP
bam-7218	575	77	synergy	synergy	NOUN
bam-7218	575	78	ablation	ablation	NOUN
bam-7218	575	79	of	of	ADP
bam-7218	575	80	the	the	DET
bam-7218	575	81	gastrocnemius	gastrocnemius	NOUN
bam-7218	575	82	and	and	CCONJ
bam-7218	575	83	soleus	soleus	ADJ
bam-7218	575	84	muscles	muscle	NOUN
bam-7218	575	85	.	.	PUNCT
bam-7218	576	1	pln	pln	PROPN
bam-7218	576	2	muscles	muscle	NOUN
bam-7218	576	3	were	be	AUX
bam-7218	576	4	analyzed	analyze	VERB
bam-7218	576	5	1	1	NUM
bam-7218	576	6	or	or	CCONJ
bam-7218	576	7	4	4	NUM
bam-7218	576	8	weeks	week	NOUN
bam-7218	576	9	after	after	ADP
bam-7218	576	10	mechanical	mechanical	ADJ
bam-7218	576	11	overload	overload	NOUN
bam-7218	576	12	.	.	PUNCT
bam-7218	577	1	in	in	ADP
bam-7218	577	2	addition	addition	NOUN
bam-7218	577	3	,	,	PUNCT
bam-7218	577	4	human	human	ADJ
bam-7218	577	5	derived	derive	VERB
bam-7218	577	6	myoblasts	myoblast	NOUN
bam-7218	577	7	carrying	carry	VERB
bam-7218	577	8	the	the	DET
bam-7218	577	9	same	same	ADJ
bam-7218	577	10	mutation	mutation	NOUN
bam-7218	577	11	in	in	ADP
bam-7218	577	12	the	the	DET
bam-7218	577	13	lamin	lamin	NOUN
bam-7218	577	14	ac	ac	PROPN
bam-7218	577	15	gene	gene	NOUN
bam-7218	577	16	were	be	AUX
bam-7218	577	17	differentiated	differentiate	VERB
bam-7218	577	18	into	into	ADP
bam-7218	577	19	myotubes	myotube	NOUN
bam-7218	577	20	and	and	CCONJ
bam-7218	577	21	subjected	subject	VERB
bam-7218	577	22	to	to	ADP
bam-7218	577	23	cyclic	cyclic	ADJ
bam-7218	577	24	stretch	stretch	NOUN
bam-7218	577	25	.	.	PUNCT
bam-7218	578	1	in	in	ADP
bam-7218	578	2	response	response	NOUN
bam-7218	578	3	to	to	ADP
bam-7218	578	4	1	1	NUM
bam-7218	578	5	and	and	CCONJ
bam-7218	578	6	4	4	NUM
bam-7218	578	7	weeks	week	NOUN
bam-7218	578	8	of	of	ADP
bam-7218	578	9	mechanical	mechanical	ADJ
bam-7218	578	10	overload	overload	NOUN
bam-7218	578	11	,	,	PUNCT
bam-7218	578	12	wt	wt	PROPN
bam-7218	578	13	pln	pln	PROPN
bam-7218	578	14	mass	mass	PROPN
bam-7218	578	15	/	/	SYM
bam-7218	578	16	body	body	NOUN
bam-7218	578	17	mass	mass	NOUN
bam-7218	578	18	increased	increase	VERB
bam-7218	578	19	1.9	1.9	NUM
bam-7218	578	20	and	and	CCONJ
bam-7218	578	21	2.3	2.3	NUM
bam-7218	578	22	fold	fold	NOUN
bam-7218	578	23	respectively	respectively	ADV
bam-7218	578	24	compared	compare	VERB
bam-7218	578	25	to	to	PART
bam-7218	578	26	control	control	VERB
bam-7218	578	27	wt	wt	ADP
bam-7218	578	28	,	,	PUNCT
bam-7218	578	29	but	but	CCONJ
bam-7218	578	30	lmna+/δk32	lmna+/δk32	PROPN
bam-7218	578	31	mice	mouse	NOUN
bam-7218	578	32	failed	fail	VERB
bam-7218	578	33	to	to	PART
bam-7218	578	34	produce	produce	VERB
bam-7218	578	35	a	a	DET
bam-7218	578	36	comparable	comparable	ADJ
bam-7218	578	37	hypertrophic	hypertrophic	ADJ
bam-7218	578	38	response	response	NOUN
bam-7218	578	39	(	(	PUNCT
bam-7218	578	40	1.1	1.1	NUM
bam-7218	578	41	and	and	CCONJ
bam-7218	578	42	1.6	1.6	NUM
bam-7218	578	43	fold	fold	NOUN
bam-7218	578	44	increase	increase	NOUN
bam-7218	578	45	respectively	respectively	ADV
bam-7218	578	46	compared	compare	VERB
bam-7218	578	47	to	to	ADP
bam-7218	578	48	wt	wt	PROPN
bam-7218	578	49	controls	control	NOUN
bam-7218	578	50	)	)	PUNCT
bam-7218	578	51	.	.	PUNCT
bam-7218	579	1	paradoxically	paradoxically	ADV
bam-7218	579	2	,	,	PUNCT
bam-7218	579	3	anabolic	anabolic	NOUN
bam-7218	579	4	signals	signal	NOUN
bam-7218	579	5	(	(	PUNCT
bam-7218	579	6	akt	akt	PROPN
bam-7218	579	7	/	/	SYM
bam-7218	579	8	p70s6k	p70s6k	PROPN
bam-7218	579	9	)	)	PUNCT
bam-7218	579	10	were	be	AUX
bam-7218	579	11	similarly	similarly	ADV
bam-7218	579	12	activated	activate	VERB
bam-7218	579	13	between	between	ADP
bam-7218	579	14	mouse	mouse	NOUN
bam-7218	579	15	strains	strain	NOUN
bam-7218	579	16	,	,	PUNCT
bam-7218	579	17	however	however	ADV
bam-7218	579	18	the	the	DET
bam-7218	579	19	lmna+/δk32	lmna+/δk32	NOUN
bam-7218	579	20	mice	mouse	NOUN
bam-7218	579	21	displayed	display	VERB
bam-7218	579	22	a	a	DET
bam-7218	579	23	significant	significant	ADJ
bam-7218	579	24	up	up	ADJ
bam-7218	579	25	regulation	regulation	NOUN
bam-7218	579	26	of	of	ADP
bam-7218	579	27	both	both	PRON
bam-7218	579	28	total	total	ADJ
bam-7218	579	29	and	and	CCONJ
bam-7218	579	30	de	de	ADJ
bam-7218	579	31	-	-	ADJ
bam-7218	579	32	phosphorylated	phosphorylate	VERB
bam-7218	579	33	foxo3a	foxo3a	NOUN
bam-7218	579	34	and	and	CCONJ
bam-7218	579	35	its	its	PRON
bam-7218	579	36	downstream	downstream	ADJ
bam-7218	579	37	gene	gene	NOUN
bam-7218	579	38	targets	target	NOUN
bam-7218	579	39	(	(	PUNCT
bam-7218	579	40	murf1	murf1	PROPN
bam-7218	579	41	,	,	PUNCT
bam-7218	579	42	mafbx	mafbx	PROPN
bam-7218	579	43	,	,	PUNCT
bam-7218	579	44	musa1	musa1	NOUN
bam-7218	579	45	,	,	PUNCT
bam-7218	579	46	fbxo31	fbxo31	NOUN
bam-7218	579	47	,	,	PUNCT
bam-7218	579	48	smart	smart	ADJ
bam-7218	579	49	)	)	PUNCT
bam-7218	579	50	.	.	PUNCT
bam-7218	580	1	the	the	DET
bam-7218	580	2	average	average	ADJ
bam-7218	580	3	number	number	NOUN
bam-7218	580	4	of	of	ADP
bam-7218	580	5	pax7	pax7	PROPN
bam-7218	580	6	+	+	CCONJ
bam-7218	580	7	cells	cell	NOUN
bam-7218	580	8	per	per	ADP
bam-7218	580	9	cross	cross	NOUN
bam-7218	580	10	-	-	NOUN
bam-7218	580	11	section	section	ADJ
bam-7218	580	12	and	and	CCONJ
bam-7218	580	13	pax7	pax7	ADJ
bam-7218	580	14	protein	protein	NOUN
bam-7218	580	15	expression	expression	NOUN
bam-7218	580	16	were	be	AUX
bam-7218	580	17	significantly	significantly	ADV
bam-7218	580	18	lower	low	ADJ
bam-7218	580	19	in	in	ADP
bam-7218	580	20	lmna+/δk32	lmna+/δk32	PROPN
bam-7218	580	21	pln	pln	PROPN
bam-7218	580	22	compared	compare	VERB
bam-7218	580	23	to	to	ADP
bam-7218	580	24	wt	wt	PROPN
bam-7218	580	25	.	.	PUNCT
bam-7218	581	1	in	in	ADP
bam-7218	581	2	addition	addition	NOUN
bam-7218	581	3	,	,	PUNCT
bam-7218	581	4	we	we	PRON
bam-7218	581	5	observed	observe	VERB
bam-7218	581	6	a	a	DET
bam-7218	581	7	high	high	ADJ
bam-7218	581	8	rate	rate	NOUN
bam-7218	581	9	of	of	ADP
bam-7218	581	10	fragmentation	fragmentation	NOUN
bam-7218	581	11	of	of	ADP
bam-7218	581	12	the	the	DET
bam-7218	581	13	neuromuscular	neuromuscular	ADJ
bam-7218	581	14	junction	junction	NOUN
bam-7218	581	15	(	(	PUNCT
bam-7218	581	16	nmj	nmj	NOUN
bam-7218	581	17	)	)	PUNCT
bam-7218	581	18	following	follow	VERB
bam-7218	581	19	overload	overload	NOUN
bam-7218	581	20	whereas	whereas	SCONJ
bam-7218	581	21	wt	wt	PROPN
bam-7218	581	22	pln	pln	PROPN
bam-7218	581	23	were	be	AUX
bam-7218	581	24	characterized	characterize	VERB
bam-7218	581	25	by	by	ADP
bam-7218	581	26	nmj	nmj	NOUN
bam-7218	581	27	hypertrophy	hypertrophy	NOUN
bam-7218	581	28	.	.	PUNCT
bam-7218	582	1	in	in	ADP
bam-7218	582	2	vitro	vitro	X
bam-7218	582	3	data	datum	NOUN
bam-7218	582	4	showed	show	VERB
bam-7218	582	5	that	that	SCONJ
bam-7218	582	6	myotube	myotube	NOUN
bam-7218	582	7	morphology	morphology	NOUN
bam-7218	582	8	was	be	AUX
bam-7218	582	9	markedly	markedly	ADV
bam-7218	582	10	different	different	ADJ
bam-7218	582	11	between	between	ADP
bam-7218	582	12	cell	cell	NOUN
bam-7218	582	13	types	type	NOUN
bam-7218	582	14	with	with	ADP
bam-7218	582	15	increased	increase	VERB
bam-7218	582	16	myotube	myotube	NOUN
bam-7218	582	17	size	size	NOUN
bam-7218	582	18	,	,	PUNCT
bam-7218	582	19	nuclei	nucleus	NOUN
bam-7218	582	20	per	per	ADP
bam-7218	582	21	myotube	myotube	NOUN
bam-7218	582	22	and	and	CCONJ
bam-7218	582	23	cytoskeletal	cytoskeletal	ADJ
bam-7218	582	24	disorganization	disorganization	NOUN
bam-7218	582	25	observed	observe	VERB
bam-7218	582	26	in	in	ADP
bam-7218	582	27	lmna+/δk32	lmna+/δk32	NOUN
bam-7218	582	28	vs	vs	ADP
bam-7218	582	29	wt	wt	PROPN
bam-7218	582	30	myotubes	myotube	NOUN
bam-7218	582	31	.	.	PUNCT
bam-7218	583	1	acute	acute	ADJ
bam-7218	583	2	mechanoresponsiveness	mechanoresponsiveness	NOUN
bam-7218	583	3	of	of	ADP
bam-7218	583	4	lmna+/δk32	lmna+/δk32	PROPN
bam-7218	583	5	myotubes	myotube	NOUN
bam-7218	583	6	was	be	AUX
bam-7218	583	7	aberrant	aberrant	ADJ
bam-7218	583	8	in	in	ADP
bam-7218	583	9	vitro	vitro	X
bam-7218	583	10	as	as	SCONJ
bam-7218	583	11	determined	determine	VERB
bam-7218	583	12	by	by	ADP
bam-7218	583	13	abnormal	abnormal	ADJ
bam-7218	583	14	localization	localization	NOUN
bam-7218	583	15	and	and	CCONJ
bam-7218	583	16	activity	activity	NOUN
bam-7218	583	17	following	follow	VERB
bam-7218	583	18	stretch	stretch	NOUN
bam-7218	583	19	of	of	ADP
bam-7218	583	20	the	the	DET
bam-7218	583	21	mechanosensitive	mechanosensitive	ADJ
bam-7218	583	22	proteins	protein	NOUN
bam-7218	583	23	yap	yap	NOUN
bam-7218	583	24	and	and	CCONJ
bam-7218	583	25	mkl1	mkl1	NOUN
bam-7218	583	26	accompanied	accompany	VERB
bam-7218	583	27	by	by	ADP
bam-7218	583	28	a	a	DET
bam-7218	583	29	lack	lack	NOUN
bam-7218	583	30	of	of	ADP
bam-7218	583	31	cytoskeleton	cytoskeleton	NOUN
bam-7218	583	32	reorganization	reorganization	NOUN
bam-7218	583	33	in	in	ADP
bam-7218	583	34	lmna+/δk32	lmna+/δk32	PROPN
bam-7218	583	35	myotubes	myotube	NOUN
bam-7218	583	36	.	.	PUNCT
bam-7218	584	1	in	in	ADP
bam-7218	584	2	conclusion	conclusion	NOUN
bam-7218	584	3	,	,	PUNCT
bam-7218	584	4	our	our	PRON
bam-7218	584	5	results	result	NOUN
bam-7218	584	6	show	show	VERB
bam-7218	584	7	that	that	SCONJ
bam-7218	584	8	the	the	DET
bam-7218	584	9	muscle	muscle	NOUN
bam-7218	584	10	ability	ability	NOUN
bam-7218	584	11	to	to	PART
bam-7218	584	12	sense	sense	VERB
bam-7218	584	13	and	and	CCONJ
bam-7218	584	14	respond	respond	VERB
bam-7218	584	15	to	to	ADP
bam-7218	584	16	mechanical	mechanical	ADJ
bam-7218	584	17	overload	overload	NOUN
bam-7218	584	18	is	be	AUX
bam-7218	584	19	severely	severely	ADV
bam-7218	584	20	disturbed	disturb	VERB
bam-7218	584	21	in	in	ADP
bam-7218	584	22	l	l	NOUN
bam-7218	584	23	-	-	PUNCT
bam-7218	584	24	cmd	cmd	NOUN
bam-7218	584	25	.	.	PUNCT
bam-7218	585	1	these	these	DET
bam-7218	585	2	data	datum	NOUN
bam-7218	585	3	highlight	highlight	VERB
bam-7218	585	4	the	the	DET
bam-7218	585	5	importance	importance	NOUN
bam-7218	585	6	of	of	ADP
bam-7218	585	7	the	the	DET
bam-7218	585	8	nuclear	nuclear	ADJ
bam-7218	585	9	envelope	envelope	NOUN
bam-7218	585	10	in	in	ADP
bam-7218	585	11	mechanosensing	mechanosense	VERB
bam-7218	585	12	,	,	PUNCT
bam-7218	585	13	shedding	shed	VERB
bam-7218	585	14	light	light	NOUN
bam-7218	585	15	on	on	ADP
bam-7218	585	16	the	the	DET
bam-7218	585	17	intrinsic	intrinsic	ADJ
bam-7218	585	18	force	force	NOUN
bam-7218	585	19	sensing	sense	VERB
bam-7218	585	20	mechanisms	mechanism	NOUN
bam-7218	585	21	in	in	ADP
bam-7218	585	22	skeletal	skeletal	ADJ
bam-7218	585	23	muscle	muscle	NOUN
bam-7218	585	24	.	.	PUNCT
bam-7218	586	1	5.5	5.5	NUM
bam-7218	586	2	monitoring	monitor	VERB
bam-7218	586	3	oxygen	oxygen	NOUN
bam-7218	586	4	-	-	PUNCT
bam-7218	586	5	sensors	sensor	NOUN
bam-7218	586	6	in	in	ADP
bam-7218	586	7	cardiac	cardiac	ADJ
bam-7218	586	8	hypertrophy	hypertrophy	NOUN
bam-7218	586	9	using	use	VERB
bam-7218	586	10	a	a	DET
bam-7218	586	11	non	non	ADJ
bam-7218	586	12	-	-	ADJ
bam-7218	586	13	pressure	pressure	ADJ
bam-7218	586	14	overload	overload	NOUN
bam-7218	586	15	animal	animal	NOUN
bam-7218	586	16	model	model	NOUN
bam-7218	586	17	giulia	giulia	PROPN
bam-7218	586	18	belotti	belotti	PROPN
bam-7218	586	19	(	(	PUNCT
bam-7218	586	20	a	a	X
bam-7218	586	21	)	)	PUNCT
bam-7218	586	22	,	,	PUNCT
bam-7218	586	23	gabriele	gabriele	PROPN
bam-7218	586	24	ceccarelli	ceccarelli	PROPN
bam-7218	586	25	(	(	PUNCT
bam-7218	586	26	a	a	DET
bam-7218	586	27	,	,	PUNCT
bam-7218	586	28	b	b	NOUN
bam-7218	586	29	)	)	PUNCT
bam-7218	586	30	,	,	PUNCT
bam-7218	586	31	laura	laura	PROPN
bam-7218	586	32	benedetti	benedetti	PROPN
bam-7218	586	33	(	(	PUNCT
bam-7218	586	34	a	a	DET
bam-7218	586	35	,	,	PUNCT
bam-7218	586	36	b	b	NOUN
bam-7218	586	37	)	)	PUNCT
bam-7218	586	38	,	,	PUNCT
bam-7218	586	39	francesca	francesca	PROPN
bam-7218	586	40	mulas	mulas	PROPN
bam-7218	586	41	(	(	PUNCT
bam-7218	586	42	b	b	NOUN
bam-7218	586	43	,	,	PUNCT
bam-7218	586	44	d	d	NOUN
bam-7218	586	45	)	)	PUNCT
bam-7218	586	46	,	,	PUNCT
bam-7218	586	47	riccardo	riccardo	NOUN
bam-7218	586	48	bellazzi	bellazzi	NOUN
bam-7218	586	49	(	(	PUNCT
bam-7218	586	50	2,4	2,4	NUM
bam-7218	586	51	)	)	PUNCT
bam-7218	586	52	,	,	PUNCT
bam-7218	586	53	maria	maria	PROPN
bam-7218	586	54	gabriella	gabriella	PROPN
bam-7218	586	55	cusella	cusella	PROPN
bam-7218	586	56	de	de	X
bam-7218	586	57	angelis	angelis	PROPN
bam-7218	586	58	(	(	PUNCT
bam-7218	586	59	a	a	DET
bam-7218	586	60	,	,	PUNCT
bam-7218	586	61	b	b	NOUN
bam-7218	586	62	)	)	PUNCT
bam-7218	586	63	,	,	PUNCT
bam-7218	586	64	maurilio	maurilio	NOUN
bam-7218	586	65	sampaolesi	sampaolesi	NOUN
bam-7218	586	66	(	(	PUNCT
bam-7218	586	67	a	a	DET
bam-7218	586	68	,	,	PUNCT
bam-7218	586	69	b	b	NOUN
bam-7218	586	70	,	,	PUNCT
bam-7218	586	71	c	c	NOUN
bam-7218	586	72	)	)	PUNCT
bam-7218	586	73	,	,	PUNCT
bam-7218	586	74	flavio	flavio	PROPN
bam-7218	586	75	lorenzo	lorenzo	PROPN
bam-7218	586	76	ronzoni	ronzoni	VERB
bam-7218	586	77	(	(	PUNCT
bam-7218	586	78	a	a	DET
bam-7218	586	79	,	,	PUNCT
bam-7218	586	80	b	b	NOUN
bam-7218	586	81	)	)	PUNCT
bam-7218	586	82	(	(	PUNCT
bam-7218	586	83	a	a	X
bam-7218	586	84	)	)	PUNCT
bam-7218	586	85	dept	dept	NOUN
bam-7218	586	86	public	public	ADJ
bam-7218	586	87	health	health	NOUN
bam-7218	586	88	,	,	PUNCT
bam-7218	586	89	experimental	experimental	ADJ
bam-7218	586	90	and	and	CCONJ
bam-7218	586	91	forensic	forensic	ADJ
bam-7218	586	92	medicine	medicine	NOUN
bam-7218	586	93	,	,	PUNCT
bam-7218	586	94	university	university	NOUN
bam-7218	586	95	of	of	ADP
bam-7218	586	96	pavia	pavia	PROPN
bam-7218	586	97	,	,	PUNCT
bam-7218	586	98	italy	italy	PROPN
bam-7218	586	99	;	;	PUNCT
bam-7218	586	100	(	(	PUNCT
bam-7218	586	101	b	b	X
bam-7218	586	102	)	)	PUNCT
bam-7218	586	103	center	center	NOUN
bam-7218	586	104	for	for	ADP
bam-7218	586	105	health	health	NOUN
bam-7218	586	106	technologies	technology	NOUN
bam-7218	586	107	(	(	PUNCT
bam-7218	586	108	c.h.t	c.h.t	NOUN
bam-7218	586	109	.	.	PUNCT
bam-7218	586	110	)	)	PUNCT
bam-7218	586	111	,	,	PUNCT
bam-7218	586	112	university	university	NOUN
bam-7218	586	113	of	of	ADP
bam-7218	586	114	pavia	pavia	PROPN
bam-7218	586	115	,	,	PUNCT
bam-7218	586	116	italy	italy	PROPN
bam-7218	586	117	;	;	PUNCT
bam-7218	586	118	(	(	PUNCT
bam-7218	586	119	c	c	X
bam-7218	586	120	)	)	PUNCT
bam-7218	586	121	dept	dept	NOUN
bam-7218	586	122	development	development	NOUN
bam-7218	586	123	and	and	CCONJ
bam-7218	586	124	regeneration	regeneration	NOUN
bam-7218	586	125	,	,	PUNCT
bam-7218	586	126	ku	ku	PROPN
bam-7218	586	127	leuven	leuven	PROPN
bam-7218	586	128	,	,	PUNCT
bam-7218	586	129	belgium	belgium	NOUN
bam-7218	586	130	;	;	PUNCT
bam-7218	586	131	(	(	PUNCT
bam-7218	586	132	d	d	X
bam-7218	586	133	)	)	PUNCT
bam-7218	586	134	dept	dept	NOUN
bam-7218	586	135	of	of	ADP
bam-7218	586	136	electrical	electrical	ADJ
bam-7218	586	137	,	,	PUNCT
bam-7218	586	138	computer	computer	NOUN
bam-7218	586	139	and	and	CCONJ
bam-7218	586	140	biomedical	biomedical	ADJ
bam-7218	586	141	engineering	engineering	NOUN
bam-7218	586	142	,	,	PUNCT
bam-7218	586	143	university	university	NOUN
bam-7218	586	144	of	of	ADP
bam-7218	586	145	pavia	pavia	PROPN
bam-7218	586	146	,	,	PUNCT
bam-7218	586	147	italy	italy	PROPN
bam-7218	586	148	.	.	PUNCT
bam-7218	587	1	e	e	X
bam-7218	587	2	-	-	NOUN
bam-7218	587	3	mail	mail	NOUN
bam-7218	587	4	:	:	PUNCT
bam-7218	587	5	flavio.ronzoni@unipv.it	flavio.ronzoni@unipv.it	NOUN
bam-7218	587	6	met	meet	VERB
bam-7218	587	7	activating	activate	VERB
bam-7218	587	8	genetically	genetically	ADV
bam-7218	587	9	improved	improve	VERB
bam-7218	587	10	chimeric	chimeric	ADJ
bam-7218	587	11	factor	factor	NOUN
bam-7218	587	12	1	1	NUM
bam-7218	587	13	(	(	PUNCT
bam-7218	587	14	magic	magic	NOUN
bam-7218	587	15	-	-	PUNCT
bam-7218	587	16	f1	f1	NOUN
bam-7218	587	17	)	)	PUNCT
bam-7218	587	18	is	be	AUX
bam-7218	587	19	a	a	DET
bam-7218	587	20	human	human	ADJ
bam-7218	587	21	recombinant	recombinant	ADJ
bam-7218	587	22	protein	protein	NOUN
bam-7218	587	23	,	,	PUNCT
bam-7218	587	24	derived	derive	VERB
bam-7218	587	25	from	from	ADP
bam-7218	587	26	dimerization	dimerization	NOUN
bam-7218	587	27	of	of	ADP
bam-7218	587	28	the	the	DET
bam-7218	587	29	receptor	receptor	NOUN
bam-7218	587	30	-	-	PUNCT
bam-7218	587	31	binding	bind	VERB
bam-7218	587	32	domain	domain	NOUN
bam-7218	587	33	of	of	ADP
bam-7218	587	34	hepatocyte	hepatocyte	NOUN
bam-7218	587	35	growth	growth	NOUN
bam-7218	587	36	factor	factor	NOUN
bam-7218	587	37	(	(	PUNCT
bam-7218	587	38	hgf	hgf	PROPN
bam-7218	587	39	)	)	PUNCT
bam-7218	587	40	.	.	PUNCT
bam-7218	588	1	previous	previous	ADJ
bam-7218	588	2	experiments	experiment	NOUN
bam-7218	588	3	demonstrate	demonstrate	VERB
bam-7218	588	4	that	that	SCONJ
bam-7218	588	5	in	in	ADP
bam-7218	588	6	hemizigous	hemizigous	ADJ
bam-7218	588	7	transgenic	transgenic	NOUN
bam-7218	588	8	mice	mouse	NOUN
bam-7218	588	9	,	,	PUNCT
bam-7218	588	10	the	the	DET
bam-7218	588	11	skeletal	skeletal	ADJ
bam-7218	588	12	muscle	muscle	NOUN
bam-7218	588	13	specific	specific	ADJ
bam-7218	588	14	expression	expression	NOUN
bam-7218	588	15	of	of	ADP
bam-7218	588	16	magic	magic	ADJ
bam-7218	588	17	-	-	PUNCT
bam-7218	588	18	f1	f1	NOUN
bam-7218	588	19	can	can	AUX
bam-7218	588	20	induce	induce	VERB
bam-7218	588	21	a	a	DET
bam-7218	588	22	constitutive	constitutive	ADJ
bam-7218	588	23	muscular	muscular	ADJ
bam-7218	588	24	hypertrophy	hypertrophy	NOUN
bam-7218	588	25	,	,	PUNCT
bam-7218	588	26	improving	improve	VERB
bam-7218	588	27	running	running	NOUN
bam-7218	588	28	performance	performance	NOUN
bam-7218	588	29	and	and	CCONJ
bam-7218	588	30	accelerating	accelerate	VERB
bam-7218	588	31	muscle	muscle	NOUN
bam-7218	588	32	regeneration	regeneration	NOUN
bam-7218	588	33	after	after	ADP
bam-7218	588	34	injury	injury	NOUN
bam-7218	588	35	[	[	X
bam-7218	588	36	1	1	NUM
bam-7218	588	37	]	]	PUNCT
bam-7218	588	38	.	.	PUNCT
bam-7218	589	1	furthermore	furthermore	ADV
bam-7218	589	2	,	,	PUNCT
bam-7218	589	3	the	the	DET
bam-7218	589	4	microarray	microarray	NOUN
bam-7218	589	5	analysis	analysis	NOUN
bam-7218	589	6	of	of	ADP
bam-7218	589	7	magic	magic	ADJ
bam-7218	589	8	-	-	PUNCT
bam-7218	589	9	f1+/+	f1+/+	PROPN
bam-7218	589	10	satellite	satellite	NOUN
bam-7218	589	11	cells	cell	NOUN
bam-7218	589	12	evidenced	evidence	VERB
bam-7218	589	13	transcriptomic	transcriptomic	ADJ
bam-7218	589	14	changes	change	NOUN
bam-7218	589	15	in	in	ADP
bam-7218	589	16	genes	gene	NOUN
bam-7218	589	17	involved	involve	VERB
bam-7218	589	18	in	in	ADP
bam-7218	589	19	the	the	DET
bam-7218	589	20	control	control	NOUN
bam-7218	589	21	of	of	ADP
bam-7218	589	22	muscle	muscle	NOUN
bam-7218	589	23	growth	growth	NOUN
bam-7218	589	24	,	,	PUNCT
bam-7218	589	25	development	development	NOUN
bam-7218	589	26	and	and	CCONJ
bam-7218	589	27	vascularisation	vascularisation	NOUN
bam-7218	589	28	[	[	X
bam-7218	589	29	2	2	NUM
bam-7218	589	30	]	]	PUNCT
bam-7218	589	31	.	.	PUNCT
bam-7218	590	1	in	in	ADP
bam-7218	590	2	this	this	DET
bam-7218	590	3	study	study	NOUN
bam-7218	590	4	we	we	PRON
bam-7218	590	5	demonstrate	demonstrate	VERB
bam-7218	590	6	that	that	SCONJ
bam-7218	590	7	magic	magic	ADJ
bam-7218	590	8	-	-	PUNCT
bam-7218	590	9	f1	f1	NOUN
bam-7218	590	10	mice	mouse	NOUN
bam-7218	590	11	show	show	VERB
bam-7218	590	12	an	an	DET
bam-7218	590	13	alteration	alteration	NOUN
bam-7218	590	14	of	of	ADP
bam-7218	590	15	the	the	DET
bam-7218	590	16	heart	heart	NOUN
bam-7218	590	17	morphology	morphology	NOUN
bam-7218	590	18	.	.	PUNCT
bam-7218	591	1	data	datum	NOUN
bam-7218	591	2	obtained	obtain	VERB
bam-7218	591	3	by	by	ADP
bam-7218	591	4	morphometric	morphometric	ADJ
bam-7218	591	5	analysis	analysis	NOUN
bam-7218	591	6	and	and	CCONJ
bam-7218	591	7	three	three	NUM
bam-7218	591	8	-	-	PUNCT
bam-7218	591	9	dimensional	dimensional	ADJ
bam-7218	591	10	reconstruction	reconstruction	NOUN
bam-7218	591	11	of	of	ADP
bam-7218	591	12	the	the	DET
bam-7218	591	13	hearth	hearth	NOUN
bam-7218	591	14	revealed	reveal	VERB
bam-7218	591	15	that	that	SCONJ
bam-7218	591	16	circulating	circulate	VERB
bam-7218	591	17	magic	magic	ADJ
bam-7218	591	18	-	-	PUNCT
bam-7218	591	19	f1	f1	NOUN
bam-7218	591	20	proteins	protein	NOUN
bam-7218	591	21	are	be	AUX
bam-7218	591	22	able	able	ADJ
bam-7218	591	23	to	to	PART
bam-7218	591	24	induce	induce	VERB
bam-7218	591	25	a	a	DET
bam-7218	591	26	dilatation	dilatation	NOUN
bam-7218	591	27	of	of	ADP
bam-7218	591	28	the	the	DET
bam-7218	591	29	left	left	ADJ
bam-7218	591	30	ventricle	ventricle	NOUN
bam-7218	591	31	chamber	chamber	NOUN
bam-7218	591	32	of	of	ADP
bam-7218	591	33	transgenic	transgenic	NOUN
bam-7218	591	34	mice	mouse	NOUN
bam-7218	591	35	.	.	PUNCT
bam-7218	592	1	interestingly	interestingly	ADV
bam-7218	592	2	,	,	PUNCT
bam-7218	592	3	we	we	PRON
bam-7218	592	4	found	find	VERB
bam-7218	592	5	in	in	ADP
bam-7218	592	6	magic	magic	ADJ
bam-7218	592	7	-	-	PUNCT
bam-7218	592	8	f1	f1	NOUN
bam-7218	592	9	hearts	heart	NOUN
bam-7218	592	10	an	an	DET
bam-7218	592	11	alteration	alteration	NOUN
bam-7218	592	12	of	of	ADP
bam-7218	592	13	phd2	phd2	NOUN
bam-7218	592	14	and	and	CCONJ
bam-7218	592	15	hif1	hif1	NOUN
bam-7218	592	16	protein	protein	NOUN
bam-7218	592	17	levels	level	NOUN
bam-7218	592	18	.	.	PUNCT
bam-7218	593	1	these	these	DET
bam-7218	593	2	two	two	NUM
bam-7218	593	3	oxygen	oxygen	NOUN
bam-7218	593	4	sensors	sensor	NOUN
bam-7218	593	5	are	be	AUX
bam-7218	593	6	found	find	VERB
bam-7218	593	7	dysregulated	dysregulate	VERB
bam-7218	593	8	in	in	ADP
bam-7218	593	9	cardiac	cardiac	ADJ
bam-7218	593	10	ischaemic	ischaemic	ADJ
bam-7218	593	11	conditions	condition	NOUN
bam-7218	593	12	,	,	PUNCT
bam-7218	593	13	where	where	SCONJ
bam-7218	593	14	generalised	generalised	ADJ
bam-7218	593	15	hypoxia	hypoxia	NOUN
bam-7218	593	16	causes	cause	VERB
bam-7218	593	17	functional	functional	ADJ
bam-7218	593	18	impairments	impairment	NOUN
bam-7218	593	19	in	in	ADP
bam-7218	593	20	cardiomyocytes	cardiomyocyte	NOUN
bam-7218	593	21	and	and	CCONJ
bam-7218	593	22	structural	structural	ADJ
bam-7218	593	23	tissue	tissue	NOUN
bam-7218	593	24	damage	damage	NOUN
bam-7218	594	1	[	[	X
bam-7218	594	2	3	3	NUM
bam-7218	594	3	-	-	SYM
bam-7218	594	4	4	4	NUM
bam-7218	594	5	]	]	PUNCT
bam-7218	594	6	.	.	PUNCT
bam-7218	595	1	these	these	DET
bam-7218	595	2	preliminary	preliminary	ADJ
bam-7218	595	3	results	result	NOUN
bam-7218	595	4	support	support	VERB
bam-7218	595	5	the	the	DET
bam-7218	595	6	involvement	involvement	NOUN
bam-7218	595	7	of	of	ADP
bam-7218	595	8	oxygen	oxygen	NOUN
bam-7218	595	9	sensors	sensor	NOUN
bam-7218	595	10	in	in	ADP
bam-7218	595	11	magic	magic	ADJ
bam-7218	595	12	-	-	PUNCT
bam-7218	595	13	f1	f1	NOUN
bam-7218	595	14	-	-	PUNCT
bam-7218	595	15	induced	induce	VERB
bam-7218	595	16	cardiac	cardiac	ADJ
bam-7218	595	17	hypertrophy	hypertrophy	NOUN
bam-7218	595	18	.	.	PUNCT
bam-7218	596	1	in	in	ADP
bam-7218	596	2	addition	addition	NOUN
bam-7218	596	3	,	,	PUNCT
bam-7218	596	4	magic	magic	ADJ
bam-7218	596	5	-	-	PUNCT
bam-7218	596	6	f1+/+	f1+/+	NOUN
bam-7218	596	7	mice	mouse	NOUN
bam-7218	596	8	can	can	AUX
bam-7218	596	9	be	be	AUX
bam-7218	596	10	used	use	VERB
bam-7218	596	11	as	as	ADP
bam-7218	596	12	non	non	ADJ
bam-7218	596	13	-	-	ADJ
bam-7218	596	14	pressure	pressure	ADJ
bam-7218	596	15	overload	overload	NOUN
bam-7218	596	16	model	model	NOUN
bam-7218	596	17	to	to	PART
bam-7218	596	18	further	far	ADV
bam-7218	596	19	investigate	investigate	VERB
bam-7218	596	20	the	the	DET
bam-7218	596	21	role	role	NOUN
bam-7218	596	22	of	of	ADP
bam-7218	596	23	oxygen	oxygen	NOUN
bam-7218	596	24	-	-	PUNCT
bam-7218	596	25	sensors	sensor	NOUN
bam-7218	596	26	in	in	ADP
bam-7218	596	27	ischaemic	ischaemic	ADJ
bam-7218	596	28	heart	heart	NOUN
bam-7218	596	29	disease	disease	NOUN
bam-7218	596	30	.	.	PUNCT
bam-7218	597	1	references	reference	NOUN
bam-7218	597	2	:	:	PUNCT
bam-7218	597	3	1	1	X
bam-7218	597	4	.	.	X
bam-7218	597	5	cassano	cassano	PROPN
bam-7218	597	6	m	m	PROPN
bam-7218	597	7	et	et	PROPN
bam-7218	597	8	al	al	PROPN
bam-7218	597	9	.	.	PUNCT
bam-7218	597	10	(	(	PUNCT
bam-7218	597	11	2008	2008	NUM
bam-7218	597	12	)	)	PUNCT
bam-7218	597	13	.	.	PUNCT
bam-7218	598	1	magic	magic	ADJ
bam-7218	598	2	-	-	PUNCT
bam-7218	598	3	factor	factor	NOUN
bam-7218	598	4	1	1	NUM
bam-7218	598	5	,	,	PUNCT
bam-7218	598	6	a	a	DET
bam-7218	598	7	partial	partial	ADJ
bam-7218	598	8	agonist	agonist	NOUN
bam-7218	598	9	of	of	ADP
bam-7218	598	10	met	meet	VERB
bam-7218	598	11	,	,	PUNCT
bam-7218	598	12	induces	induce	VERB
bam-7218	598	13	muscle	muscle	NOUN
bam-7218	598	14	hypertrophy	hypertrophy	NOUN
bam-7218	598	15	by	by	ADP
bam-7218	598	16	protecting	protect	VERB
bam-7218	598	17	myogenic	myogenic	ADJ
bam-7218	598	18	progenitors	progenitor	NOUN
bam-7218	598	19	from	from	ADP
bam-7218	598	20	apoptosis	apoptosis	NOUN
bam-7218	598	21	.	.	PUNCT
bam-7218	599	1	plos	plos	PROPN
bam-7218	599	2	one	one	NUM
bam-7218	599	3	.	.	PUNCT
bam-7218	599	4	2008	2008	NUM
bam-7218	599	5	3(9	3(9	NUM
bam-7218	599	6	):	):	PUNCT
bam-7218	599	7	e3223	e3223	NOUN
bam-7218	599	8	.	.	PUNCT
bam-7218	600	1	2	2	X
bam-7218	600	2	.	.	X
bam-7218	600	3	ronzoni	ronzoni	VERB
bam-7218	600	4	f	f	PROPN
bam-7218	600	5	et	et	PROPN
bam-7218	600	6	al	al	PROPN
bam-7218	600	7	.	.	PROPN
bam-7218	601	1	(	(	PUNCT
bam-7218	601	2	2017	2017	NUM
bam-7218	601	3	)	)	PUNCT
bam-7218	601	4	.	.	PUNCT
bam-7218	602	1	met	met	AUX
bam-7218	602	2	-	-	PUNCT
bam-7218	602	3	activating	activate	VERB
bam-7218	602	4	genetically	genetically	ADV
bam-7218	602	5	improved	improve	VERB
bam-7218	602	6	chimeric	chimeric	NOUN
bam-7218	602	7	factor-1	factor-1	NUM
bam-7218	602	8	promotes	promote	VERB
bam-7218	602	9	angiogenesis	angiogenesis	NOUN
bam-7218	602	10	and	and	CCONJ
bam-7218	602	11	hypertrophy	hypertrophy	NOUN
bam-7218	602	12	in	in	ADP
bam-7218	602	13	adult	adult	NOUN
bam-7218	602	14	myogenesis	myogenesis	NOUN
bam-7218	602	15	.	.	PUNCT
bam-7218	603	1	curr	curr	PROPN
bam-7218	603	2	pharm	pharm	PROPN
bam-7218	603	3	biotechnol	biotechnol	PROPN
bam-7218	603	4	.	.	PUNCT
bam-7218	604	1	2017	2017	NUM
bam-7218	604	2	feb	feb	NOUN
bam-7218	604	3	1	1	NUM
bam-7218	604	4	.	.	NOUN
bam-7218	604	5	3	3	NUM
bam-7218	604	6	.	.	X
bam-7218	604	7	di	di	NOUN
bam-7218	604	8	conza	conza	NOUN
bam-7218	604	9	g	g	PROPN
bam-7218	604	10	et	et	PROPN
bam-7218	604	11	al	al	PROPN
bam-7218	604	12	.	.	PROPN
bam-7218	604	13	(	(	PUNCT
bam-7218	604	14	2017	2017	NUM
bam-7218	604	15	)	)	PUNCT
bam-7218	604	16	.	.	PUNCT
bam-7218	605	1	the	the	DET
bam-7218	605	2	mtor	mtor	NOUN
bam-7218	605	3	and	and	CCONJ
bam-7218	605	4	pp2a	pp2a	ADJ
bam-7218	605	5	pathways	pathway	NOUN
bam-7218	605	6	regulate	regulate	VERB
bam-7218	605	7	phd2	phd2	NOUN
bam-7218	605	8	phosphorylation	phosphorylation	NOUN
bam-7218	605	9	to	to	ADP
bam-7218	605	10	fine	fine	ADJ
bam-7218	605	11	-	-	PUNCT
bam-7218	605	12	tune	tune	NOUN
bam-7218	605	13	hif1α	hif1α	PROPN
bam-7218	605	14	levels	level	NOUN
bam-7218	605	15	and	and	CCONJ
bam-7218	605	16	colorectal	colorectal	ADJ
bam-7218	605	17	cancer	cancer	NOUN
bam-7218	605	18	cell	cell	NOUN
bam-7218	605	19	survival	survival	NOUN
bam-7218	605	20	under	under	ADP
bam-7218	605	21	hypoxia	hypoxia	NOUN
bam-7218	605	22	.	.	PUNCT
bam-7218	606	1	cell	cell	NOUN
bam-7218	606	2	rep	rep	PROPN
bam-7218	606	3	.	.	PROPN
bam-7218	606	4	2017	2017	NUM
bam-7218	606	5	feb	feb	NOUN
bam-7218	606	6	14	14	NUM
bam-7218	606	7	.	.	PUNCT
bam-7218	607	1	4	4	X
bam-7218	607	2	.	.	X
bam-7218	608	1	piccoli	piccoli	PROPN
bam-7218	608	2	m	m	VERB
bam-7218	608	3	et	et	VERB
bam-7218	608	4	al	al	PROPN
bam-7218	608	5	(	(	PUNCT
bam-7218	608	6	2016	2016	NUM
bam-7218	608	7	)	)	PUNCT
bam-7218	608	8	.	.	PUNCT
bam-7218	609	1	a	a	DET
bam-7218	609	2	chemical	chemical	ADJ
bam-7218	609	3	approach	approach	NOUN
bam-7218	609	4	to	to	ADP
bam-7218	609	5	myocardial	myocardial	ADJ
bam-7218	609	6	protection	protection	NOUN
bam-7218	609	7	and	and	CCONJ
bam-7218	609	8	regeneration	regeneration	NOUN
bam-7218	609	9	.	.	PUNCT
bam-7218	610	1	eur	eur	PROPN
bam-7218	610	2	heart	heart	NOUN
bam-7218	610	3	j	j	PROPN
bam-7218	610	4	suppl	suppl	PROPN
bam-7218	610	5	.	.	PUNCT
bam-7218	611	1	2016	2016	NUM
bam-7218	611	2	apr	apr	NOUN
bam-7218	611	3	28	28	NUM
bam-7218	611	4	.	.	PUNCT
bam-7218	612	1	5.6	5.6	NUM
bam-7218	612	2	a	a	DET
bam-7218	612	3	micu1	micu1	NOUN
bam-7218	612	4	splice	splice	NOUN
bam-7218	612	5	variant	variant	ADJ
bam-7218	612	6	confers	confer	NOUN
bam-7218	612	7	high	high	ADJ
bam-7218	612	8	sensitivity	sensitivity	NOUN
bam-7218	612	9	to	to	ADP
bam-7218	612	10	the	the	DET
bam-7218	612	11	ca2	ca2	PROPN
bam-7218	612	12	+	+	PROPN
bam-7218	612	13	uptake	uptake	ADJ
bam-7218	612	14	machinery	machinery	NOUN
bam-7218	612	15	of	of	ADP
bam-7218	612	16	skeletal	skeletal	ADJ
bam-7218	612	17	muscle	muscle	NOUN
bam-7218	612	18	denis	denis	PROPN
bam-7218	612	19	vecellio	vecellio	X
bam-7218	612	20	reane	reane	PROPN
bam-7218	612	21	(	(	PUNCT
bam-7218	612	22	a	a	X
bam-7218	612	23	)	)	PUNCT
bam-7218	612	24	,	,	PUNCT
bam-7218	612	25	francesca	francesca	PROPN
bam-7218	612	26	vallese	vallese	NOUN
bam-7218	612	27	(	(	PUNCT
bam-7218	612	28	a	a	X
bam-7218	612	29	)	)	PUNCT
bam-7218	612	30	,	,	PUNCT
bam-7218	612	31	vanessa	vanessa	NOUN
bam-7218	612	32	checchetto	checchetto	NOUN
bam-7218	612	33	(	(	PUNCT
bam-7218	612	34	b	b	NOUN
bam-7218	612	35	)	)	PUNCT
bam-7218	612	36	,	,	PUNCT
bam-7218	612	37	laura	laura	NOUN
bam-7218	612	38	acquasaliente	acquasaliente	PROPN
bam-7218	612	39	(	(	PUNCT
bam-7218	612	40	c	c	NOUN
bam-7218	612	41	)	)	PUNCT
bam-7218	612	42	,	,	PUNCT
bam-7218	612	43	gaia	gaia	PROPN
bam-7218	612	44	butera	butera	PROPN
bam-7218	612	45	(	(	PUNCT
bam-7218	612	46	a	a	NOUN
bam-7218	612	47	)	)	PUNCT
bam-7218	612	48	,	,	PUNCT
bam-7218	612	49	vincenzo	vincenzo	PROPN
bam-7218	612	50	de	de	PROPN
bam-7218	612	51	filippis	filippis	PROPN
bam-7218	612	52	(	(	PUNCT
bam-7218	612	53	c	c	NOUN
bam-7218	612	54	)	)	PUNCT
bam-7218	612	55	,	,	PUNCT
bam-7218	612	56	ildikò	ildikò	PROPN
bam-7218	612	57	szabò	szabò	PROPN
bam-7218	612	58	(	(	PUNCT
bam-7218	612	59	b	b	NOUN
bam-7218	612	60	)	)	PUNCT
bam-7218	612	61	,	,	PUNCT
bam-7218	612	62	giuseppe	giuseppe	PROPN
bam-7218	612	63	zanotti	zanotti	X
bam-7218	612	64	(	(	PUNCT
bam-7218	612	65	a	a	NOUN
bam-7218	612	66	)	)	PUNCT
bam-7218	612	67	,	,	PUNCT
bam-7218	612	68	rosario	rosario	PROPN
bam-7218	612	69	rizzuto	rizzuto	PROPN
bam-7218	612	70	(	(	PUNCT
bam-7218	612	71	a	a	NOUN
bam-7218	612	72	)	)	PUNCT
bam-7218	612	73	,	,	PUNCT
bam-7218	612	74	anna	anna	PROPN
bam-7218	612	75	raffaello	raffaello	PROPN
bam-7218	612	76	(	(	PUNCT
bam-7218	612	77	a	a	NOUN
bam-7218	612	78	)	)	PUNCT
bam-7218	612	79	(	(	PUNCT
bam-7218	612	80	a	a	X
bam-7218	612	81	)	)	PUNCT
bam-7218	612	82	dept	dept	NOUN
bam-7218	612	83	of	of	ADP
bam-7218	612	84	biomedical	biomedical	ADJ
bam-7218	612	85	sciences	sciences	PROPN
bam-7218	612	86	,	,	PUNCT
bam-7218	612	87	university	university	NOUN
bam-7218	612	88	of	of	ADP
bam-7218	612	89	padova	padova	PROPN
bam-7218	612	90	,	,	PUNCT
bam-7218	612	91	italy	italy	PROPN
bam-7218	612	92	;	;	PUNCT
bam-7218	612	93	b	b	X
bam-7218	612	94	)	)	PUNCT
bam-7218	612	95	dept	dept	NOUN
bam-7218	612	96	of	of	ADP
bam-7218	612	97	biology	biology	NOUN
bam-7218	612	98	,	,	PUNCT
bam-7218	612	99	university	university	NOUN
bam-7218	612	100	of	of	ADP
bam-7218	612	101	padova	padova	PROPN
bam-7218	612	102	,	,	PUNCT
bam-7218	612	103	italy	italy	PROPN
bam-7218	612	104	;	;	PUNCT
bam-7218	612	105	(	(	PUNCT
bam-7218	612	106	c	c	X
bam-7218	612	107	)	)	PUNCT
bam-7218	612	108	dept	dept	NOUN
bam-7218	612	109	of	of	ADP
bam-7218	612	110	pharmaceutical	pharmaceutical	ADJ
bam-7218	612	111	and	and	CCONJ
bam-7218	612	112	pharmacological	pharmacological	ADJ
bam-7218	612	113	sciences	science	NOUN
bam-7218	612	114	,	,	PUNCT
bam-7218	612	115	university	university	NOUN
bam-7218	612	116	of	of	ADP
bam-7218	612	117	padova	padova	PROPN
bam-7218	612	118	,	,	PUNCT
bam-7218	612	119	italy	italy	PROPN
bam-7218	612	120	.	.	PUNCT
bam-7218	613	1	e	e	X
bam-7218	613	2	-	-	NOUN
bam-7218	613	3	mail	mail	NOUN
bam-7218	613	4	:	:	PUNCT
bam-7218	613	5	denis.vecellioreane@unipd.it	denis.vecellioreane@unipd.it	PROPN
bam-7218	613	6	mailto:flavio.ronzoni@unipv.it	mailto:flavio.ronzoni@unipv.it	PROPN
bam-7218	613	7	mailto:denis.vecellioreane@unipd.it	mailto:denis.vecellioreane@unipd.it	PROPN
bam-7218	613	8	14	14	NUM
bam-7218	613	9	th	th	NOUN
bam-7218	613	10	iiim	iiim	NOUN
bam-7218	613	11	meeting	meeting	NOUN
bam-7218	613	12	,	,	PUNCT
bam-7218	613	13	assisi	assisi	PROPN
bam-7218	613	14	,	,	PUNCT
bam-7218	613	15	italy	italy	PROPN
bam-7218	613	16	october	october	PROPN
bam-7218	613	17	12	12	NUM
bam-7218	613	18	-	-	SYM
bam-7218	613	19	15	15	NUM
bam-7218	613	20	2017	2017	NUM
bam-7218	613	21	eur	eur	PROPN
bam-7218	613	22	j	j	PROPN
bam-7218	613	23	transl	transl	PROPN
bam-7218	613	24	myol	myol	ADV
bam-7218	613	25	27	27	NUM
bam-7218	613	26	(	(	PUNCT
bam-7218	613	27	4	4	NUM
bam-7218	613	28	):	):	SYM
bam-7218	613	29	185	185	NUM
bam-7218	613	30	-	-	SYM
bam-7218	613	31	224	224	NUM
bam-7218	613	32	203	203	NUM
bam-7218	613	33	skeletal	skeletal	ADJ
bam-7218	613	34	muscle	muscle	NOUN
bam-7218	613	35	is	be	AUX
bam-7218	613	36	a	a	DET
bam-7218	613	37	dynamic	dynamic	ADJ
bam-7218	613	38	organ	organ	NOUN
bam-7218	613	39	,	,	PUNCT
bam-7218	613	40	characterized	characterize	VERB
bam-7218	613	41	by	by	ADP
bam-7218	613	42	an	an	DET
bam-7218	613	43	incredible	incredible	ADJ
bam-7218	613	44	ability	ability	NOUN
bam-7218	613	45	to	to	PART
bam-7218	613	46	rapidly	rapidly	ADV
bam-7218	613	47	increase	increase	VERB
bam-7218	613	48	its	its	PRON
bam-7218	613	49	rate	rate	NOUN
bam-7218	613	50	of	of	ADP
bam-7218	613	51	energy	energy	NOUN
bam-7218	613	52	consumption	consumption	NOUN
bam-7218	613	53	to	to	PART
bam-7218	613	54	sustain	sustain	VERB
bam-7218	613	55	activity	activity	NOUN
bam-7218	613	56	.	.	PUNCT
bam-7218	614	1	muscle	muscle	NOUN
bam-7218	614	2	mitochondria	mitochondria	PROPN
bam-7218	614	3	provide	provide	VERB
bam-7218	614	4	most	most	ADJ
bam-7218	614	5	of	of	ADP
bam-7218	614	6	the	the	DET
bam-7218	614	7	atp	atp	NOUN
bam-7218	614	8	required	require	VERB
bam-7218	614	9	for	for	ADP
bam-7218	614	10	contraction	contraction	NOUN
bam-7218	614	11	via	via	ADP
bam-7218	614	12	oxidative	oxidative	ADJ
bam-7218	614	13	phosphorylation	phosphorylation	NOUN
bam-7218	614	14	.	.	PUNCT
bam-7218	615	1	here	here	ADV
bam-7218	615	2	,	,	PUNCT
bam-7218	615	3	we	we	PRON
bam-7218	615	4	found	find	VERB
bam-7218	615	5	that	that	SCONJ
bam-7218	615	6	skeletal	skeletal	ADJ
bam-7218	615	7	muscle	muscle	NOUN
bam-7218	615	8	mitochondria	mitochondria	NOUN
bam-7218	615	9	express	express	VERB
bam-7218	615	10	a	a	DET
bam-7218	615	11	unique	unique	ADJ
bam-7218	615	12	mcu	mcu	NOUN
bam-7218	615	13	complex	complex	NOUN
bam-7218	615	14	containing	contain	VERB
bam-7218	615	15	an	an	DET
bam-7218	615	16	alternative	alternative	ADJ
bam-7218	615	17	splice	splice	NOUN
bam-7218	615	18	isoform	isoform	NOUN
bam-7218	615	19	of	of	ADP
bam-7218	615	20	micu1	micu1	NOUN
bam-7218	615	21	,	,	PUNCT
bam-7218	615	22	micu1.1	micu1.1	NUM
bam-7218	615	23	,	,	PUNCT
bam-7218	615	24	characterized	characterize	VERB
bam-7218	615	25	by	by	ADP
bam-7218	615	26	the	the	DET
bam-7218	615	27	addition	addition	NOUN
bam-7218	615	28	of	of	ADP
bam-7218	615	29	a	a	DET
bam-7218	615	30	micro	micro	NOUN
bam-7218	615	31	-	-	NOUN
bam-7218	615	32	exon	exon	ADJ
bam-7218	615	33	that	that	PRON
bam-7218	615	34	is	be	AUX
bam-7218	615	35	sufficient	sufficient	ADJ
bam-7218	615	36	to	to	PART
bam-7218	615	37	greatly	greatly	ADV
bam-7218	615	38	modify	modify	VERB
bam-7218	615	39	the	the	DET
bam-7218	615	40	properties	property	NOUN
bam-7218	615	41	of	of	ADP
bam-7218	615	42	the	the	DET
bam-7218	615	43	mcu	mcu	NOUN
bam-7218	615	44	.	.	PUNCT
bam-7218	616	1	indeed	indeed	ADV
bam-7218	616	2	,	,	PUNCT
bam-7218	616	3	micu1.1	micu1.1	PUNCT
bam-7218	616	4	binds	bind	VERB
bam-7218	616	5	ca2	ca2	PROPN
bam-7218	616	6	+	+	PROPN
bam-7218	616	7	one	one	NUM
bam-7218	616	8	order	order	NOUN
bam-7218	616	9	magnitude	magnitude	NOUN
bam-7218	616	10	more	more	ADV
bam-7218	616	11	efficiently	efficiently	ADV
bam-7218	616	12	than	than	ADP
bam-7218	616	13	micu1	micu1	NOUN
bam-7218	616	14	and	and	CCONJ
bam-7218	616	15	,	,	PUNCT
bam-7218	616	16	when	when	SCONJ
bam-7218	616	17	heterodimerized	heterodimerize	VERB
bam-7218	616	18	with	with	ADP
bam-7218	616	19	micu2	micu2	PROPN
bam-7218	616	20	,	,	PUNCT
bam-7218	616	21	activates	activate	VERB
bam-7218	616	22	mcu	mcu	PROPN
bam-7218	616	23	current	current	NOUN
bam-7218	616	24	at	at	ADP
bam-7218	616	25	lower	low	ADJ
bam-7218	616	26	ca2	ca2	PROPN
bam-7218	616	27	+	+	PROPN
bam-7218	616	28	concentrations	concentration	NOUN
bam-7218	616	29	than	than	ADP
bam-7218	616	30	micu1	micu1	NOUN
bam-7218	616	31	-	-	PUNCT
bam-7218	616	32	micu2	micu2	NOUN
bam-7218	616	33	heterodimers	heterodimer	NOUN
bam-7218	616	34	.	.	PUNCT
bam-7218	617	1	in	in	ADP
bam-7218	617	2	skeletal	skeletal	ADJ
bam-7218	617	3	muscle	muscle	NOUN
bam-7218	617	4	in	in	ADP
bam-7218	617	5	vivo	vivo	NOUN
bam-7218	617	6	,	,	PUNCT
bam-7218	617	7	micu1.1	micu1.1	ADJ
bam-7218	617	8	is	be	AUX
bam-7218	617	9	required	require	VERB
bam-7218	617	10	for	for	ADP
bam-7218	617	11	sustained	sustained	ADJ
bam-7218	617	12	mitochondrial	mitochondrial	ADJ
bam-7218	617	13	ca2	ca2	PROPN
bam-7218	617	14	+	+	CCONJ
bam-7218	617	15	uptake	uptake	ADJ
bam-7218	617	16	and	and	CCONJ
bam-7218	617	17	atp	atp	NOUN
bam-7218	617	18	production	production	NOUN
bam-7218	617	19	.	.	PUNCT
bam-7218	618	1	these	these	DET
bam-7218	618	2	results	result	NOUN
bam-7218	618	3	highlight	highlight	VERB
bam-7218	618	4	a	a	DET
bam-7218	618	5	novel	novel	ADJ
bam-7218	618	6	mechanism	mechanism	NOUN
bam-7218	618	7	of	of	ADP
bam-7218	618	8	the	the	DET
bam-7218	618	9	molecular	molecular	ADJ
bam-7218	618	10	plasticity	plasticity	NOUN
bam-7218	618	11	of	of	ADP
bam-7218	618	12	the	the	DET
bam-7218	618	13	mcu	mcu	PROPN
bam-7218	618	14	ca2	ca2	PROPN
bam-7218	618	15	+	+	PROPN
bam-7218	618	16	uptake	uptake	ADJ
bam-7218	618	17	machinery	machinery	NOUN
bam-7218	618	18	that	that	PRON
bam-7218	618	19	allows	allow	VERB
bam-7218	618	20	skeletal	skeletal	ADJ
bam-7218	618	21	muscle	muscle	NOUN
bam-7218	618	22	mitochondria	mitochondria	NOUN
bam-7218	618	23	to	to	PART
bam-7218	618	24	be	be	AUX
bam-7218	618	25	highly	highly	ADV
bam-7218	618	26	responsive	responsive	ADJ
bam-7218	618	27	to	to	ADP
bam-7218	618	28	sarcoplasmic	sarcoplasmic	NOUN
bam-7218	618	29	[	[	X
bam-7218	618	30	ca2	ca2	PROPN
bam-7218	618	31	+	+	NOUN
bam-7218	618	32	]	]	X
bam-7218	618	33	responses	response	NOUN
bam-7218	618	34	.	.	PUNCT
bam-7218	619	1	october	october	PROPN
bam-7218	619	2	14	14	NUM
bam-7218	619	3	th	th	NOUN
bam-7218	619	4	session	session	NOUN
bam-7218	619	5	6	6	NUM
bam-7218	619	6	therapeutic	therapeutic	ADJ
bam-7218	619	7	approaches	approach	NOUN
bam-7218	619	8	for	for	ADP
bam-7218	619	9	muscle	muscle	NOUN
bam-7218	619	10	diseases	disease	NOUN
bam-7218	619	11	6.1	6.1	NUM
bam-7218	619	12	the	the	DET
bam-7218	619	13	voice	voice	NOUN
bam-7218	619	14	of	of	ADP
bam-7218	619	15	patients	patient	NOUN
bam-7218	619	16	and	and	CCONJ
bam-7218	619	17	their	their	PRON
bam-7218	619	18	families	family	NOUN
bam-7218	619	19	–	–	PUNCT
bam-7218	619	20	parent	parent	NOUN
bam-7218	619	21	project	project	NOUN
bam-7218	619	22	6.2	6.2	NUM
bam-7218	619	23	improving	improve	VERB
bam-7218	619	24	the	the	DET
bam-7218	619	25	myogenic	myogenic	ADJ
bam-7218	619	26	regenerative	regenerative	ADJ
bam-7218	619	27	capacity	capacity	NOUN
bam-7218	619	28	of	of	ADP
bam-7218	619	29	induced	induced	ADJ
bam-7218	619	30	pluripotent	pluripotent	ADJ
bam-7218	619	31	stem	stem	NOUN
bam-7218	619	32	cell	cell	NOUN
bam-7218	619	33	-	-	PUNCT
bam-7218	619	34	derived	derive	VERB
bam-7218	619	35	mesodermal	mesodermal	ADJ
bam-7218	619	36	progenitors	progenitor	NOUN
bam-7218	619	37	natacha	natacha	PROPN
bam-7218	619	38	breuls	breuls	PROPN
bam-7218	619	39	(	(	PUNCT
bam-7218	619	40	a	a	X
bam-7218	619	41	)	)	PUNCT
bam-7218	619	42	,	,	PUNCT
bam-7218	619	43	domiziana	domiziana	NOUN
bam-7218	619	44	costamagna	costamagna	NOUN
bam-7218	619	45	(	(	PUNCT
bam-7218	619	46	a	a	DET
bam-7218	619	47	,	,	PUNCT
bam-7218	619	48	c	c	NOUN
bam-7218	619	49	)	)	PUNCT
bam-7218	619	50	,	,	PUNCT
bam-7218	619	51	giorgia	giorgia	PROPN
bam-7218	619	52	giacomazzi	giacomazzi	PROPN
bam-7218	619	53	(	(	PUNCT
bam-7218	619	54	a	a	NOUN
bam-7218	619	55	)	)	PUNCT
bam-7218	619	56	,	,	PUNCT
bam-7218	619	57	bryan	bryan	PROPN
bam-7218	619	58	holvoet	holvoet	PROPN
bam-7218	619	59	(	(	PUNCT
bam-7218	619	60	a	a	DET
bam-7218	619	61	,	,	PUNCT
bam-7218	619	62	b	b	NOUN
bam-7218	619	63	)	)	PUNCT
bam-7218	619	64	,	,	PUNCT
bam-7218	619	65	robin	robin	PROPN
bam-7218	619	66	duelen	duelen	PROPN
bam-7218	619	67	(	(	PUNCT
bam-7218	619	68	a	a	NOUN
bam-7218	619	69	)	)	PUNCT
bam-7218	619	70	,	,	PUNCT
bam-7218	619	71	vardine	vardine	ADJ
bam-7218	619	72	sahakyan	sahakyan	NOUN
bam-7218	619	73	(	(	PUNCT
bam-7218	619	74	a	a	NOUN
bam-7218	619	75	)	)	PUNCT
bam-7218	619	76	,	,	PUNCT
bam-7218	619	77	maurilio	maurilio	NOUN
bam-7218	619	78	sampaolesi	sampaolesi	NOUN
bam-7218	619	79	(	(	PUNCT
bam-7218	619	80	a	a	DET
bam-7218	619	81	,	,	PUNCT
bam-7218	619	82	c	c	NOUN
bam-7218	619	83	)	)	PUNCT
bam-7218	619	84	(	(	PUNCT
bam-7218	619	85	a	a	X
bam-7218	619	86	)	)	PUNCT
bam-7218	619	87	translational	translational	ADJ
bam-7218	619	88	cardiomyology	cardiomyology	NOUN
bam-7218	619	89	lab	lab	NOUN
bam-7218	619	90	,	,	PUNCT
bam-7218	619	91	dept	dept	NOUN
bam-7218	619	92	of	of	ADP
bam-7218	619	93	development	development	NOUN
bam-7218	619	94	and	and	CCONJ
bam-7218	619	95	regeneration	regeneration	NOUN
bam-7218	619	96	,	,	PUNCT
bam-7218	619	97	stem	stem	NOUN
bam-7218	619	98	cell	cell	NOUN
bam-7218	619	99	institute	institute	NOUN
bam-7218	619	100	leuven	leuven	PROPN
bam-7218	619	101	,	,	PUNCT
bam-7218	619	102	ku	ku	PROPN
bam-7218	619	103	leuven	leuven	PROPN
bam-7218	619	104	,	,	PUNCT
bam-7218	619	105	belgium	belgium	PROPN
bam-7218	619	106	;	;	PUNCT
bam-7218	619	107	
	
	SPACE
bam-7218	619	108	(	(	PUNCT
bam-7218	619	109	b	b	NOUN
bam-7218	619	110	)	)	PUNCT
bam-7218	619	111	nuclear	nuclear	ADJ
bam-7218	619	112	medicine	medicine	NOUN
bam-7218	619	113	and	and	CCONJ
bam-7218	619	114	molecular	molecular	ADJ
bam-7218	619	115	imaging	imaging	NOUN
bam-7218	619	116	,	,	PUNCT
bam-7218	619	117	dept	dept	NOUN
bam-7218	619	118	of	of	ADP
bam-7218	619	119	imaging	imaging	NOUN
bam-7218	619	120	and	and	CCONJ
bam-7218	619	121	pathology	pathology	PROPN
bam-7218	619	122	,	,	PUNCT
bam-7218	619	123	ku	ku	PROPN
bam-7218	619	124	leuven	leuven	PROPN
bam-7218	619	125	,	,	PUNCT
bam-7218	619	126	belgium	belgium	PROPN
bam-7218	619	127	;	;	PUNCT
bam-7218	619	128	
	
	SPACE
bam-7218	619	129	(	(	PUNCT
bam-7218	619	130	c	c	NOUN
bam-7218	619	131	)	)	PUNCT
bam-7218	619	132	dipartimento	dipartimento	ADP
bam-7218	619	133	di	di	PROPN
bam-7218	619	134	medicina	medicina	PROPN
bam-7218	619	135	sperimentale	sperimentale	PROPN
bam-7218	619	136	,	,	PUNCT
bam-7218	619	137	sanità	sanità	PROPN
bam-7218	619	138	pubblica	pubblica	PROPN
bam-7218	619	139	e	e	PROPN
bam-7218	619	140	forense	forense	PROPN
bam-7218	619	141	,	,	PUNCT
bam-7218	619	142	università	università	PROPN
bam-7218	619	143	degli	degli	PROPN
bam-7218	619	144	studi	studi	PROPN
bam-7218	619	145	di	di	PROPN
bam-7218	619	146	pavia	pavia	PROPN
bam-7218	619	147	,	,	PUNCT
bam-7218	619	148	italy	italy	PROPN
bam-7218	619	149	.	.	PUNCT
bam-7218	620	1	e	e	X
bam-7218	620	2	-	-	NOUN
bam-7218	620	3	mail	mail	NOUN
bam-7218	620	4	:	:	PUNCT
bam-7218	620	5	natacha.breuls@kuleuven.be	natacha.breuls@kuleuven.be	ADJ
bam-7218	620	6	pluripotent	pluripotent	ADJ
bam-7218	620	7	stem	stem	NOUN
bam-7218	620	8	cells	cell	NOUN
bam-7218	620	9	(	(	PUNCT
bam-7218	620	10	pscs	psc	NOUN
bam-7218	620	11	)	)	PUNCT
bam-7218	620	12	have	have	VERB
bam-7218	620	13	a	a	DET
bam-7218	620	14	high	high	ADJ
bam-7218	620	15	proliferative	proliferative	ADJ
bam-7218	620	16	capacity	capacity	NOUN
bam-7218	620	17	and	and	CCONJ
bam-7218	620	18	can	can	AUX
bam-7218	620	19	give	give	VERB
bam-7218	620	20	rise	rise	NOUN
bam-7218	620	21	to	to	ADP
bam-7218	620	22	all	all	DET
bam-7218	620	23	three	three	NUM
bam-7218	620	24	embryonic	embryonic	ADJ
bam-7218	620	25	germ	germ	NOUN
bam-7218	620	26	layers	layer	NOUN
bam-7218	620	27	.	.	PUNCT
bam-7218	621	1	due	due	ADP
bam-7218	621	2	to	to	ADP
bam-7218	621	3	these	these	DET
bam-7218	621	4	characteristics	characteristic	NOUN
bam-7218	621	5	,	,	PUNCT
bam-7218	621	6	pscs	psc	NOUN
bam-7218	621	7	have	have	AUX
bam-7218	621	8	been	be	AUX
bam-7218	621	9	extensively	extensively	ADV
bam-7218	621	10	researched	research	VERB
bam-7218	621	11	in	in	ADP
bam-7218	621	12	the	the	DET
bam-7218	621	13	field	field	NOUN
bam-7218	621	14	of	of	ADP
bam-7218	621	15	muscular	muscular	ADJ
bam-7218	621	16	dystrophies	dystrophy	NOUN
bam-7218	621	17	as	as	SCONJ
bam-7218	621	18	a	a	DET
bam-7218	621	19	large	large	ADJ
bam-7218	621	20	number	number	NOUN
bam-7218	621	21	of	of	ADP
bam-7218	621	22	cells	cell	NOUN
bam-7218	621	23	is	be	AUX
bam-7218	621	24	required	require	VERB
bam-7218	621	25	to	to	PART
bam-7218	621	26	restore	restore	VERB
bam-7218	621	27	the	the	DET
bam-7218	621	28	entire	entire	ADJ
bam-7218	621	29	muscle	muscle	NOUN
bam-7218	621	30	pool	pool	NOUN
bam-7218	621	31	.	.	PUNCT
bam-7218	622	1	recently	recently	ADV
bam-7218	622	2	,	,	PUNCT
bam-7218	622	3	our	our	PRON
bam-7218	622	4	group	group	NOUN
bam-7218	622	5	has	have	AUX
bam-7218	622	6	successfully	successfully	ADV
bam-7218	622	7	isolated	isolate	VERB
bam-7218	622	8	induced	induced	ADJ
bam-7218	622	9	psc	psc	NOUN
bam-7218	622	10	–	–	PUNCT
bam-7218	622	11	derived	derived	ADJ
bam-7218	622	12	mesodermal	mesodermal	ADJ
bam-7218	622	13	progenitors	progenitor	NOUN
bam-7218	622	14	(	(	PUNCT
bam-7218	622	15	mips	mips	PROPN
bam-7218	622	16	)	)	PUNCT
bam-7218	622	17	that	that	PRON
bam-7218	622	18	can	can	AUX
bam-7218	622	19	regenerate	regenerate	VERB
bam-7218	622	20	both	both	CCONJ
bam-7218	622	21	cardiac	cardiac	ADJ
bam-7218	622	22	and	and	CCONJ
bam-7218	622	23	skeletal	skeletal	ADJ
bam-7218	622	24	muscle1	muscle1	NOUN
bam-7218	622	25	.	.	PUNCT
bam-7218	623	1	nevertheless	nevertheless	ADV
bam-7218	623	2	,	,	PUNCT
bam-7218	623	3	improvements	improvement	NOUN
bam-7218	623	4	need	need	VERB
bam-7218	623	5	to	to	PART
bam-7218	623	6	be	be	AUX
bam-7218	623	7	made	make	VERB
bam-7218	623	8	to	to	PART
bam-7218	623	9	work	work	VERB
bam-7218	623	10	towards	towards	ADP
bam-7218	623	11	a	a	DET
bam-7218	623	12	clinical	clinical	ADJ
bam-7218	623	13	relevant	relevant	ADJ
bam-7218	623	14	protocol	protocol	NOUN
bam-7218	623	15	that	that	PRON
bam-7218	623	16	has	have	VERB
bam-7218	623	17	an	an	DET
bam-7218	623	18	efficacy	efficacy	NOUN
bam-7218	623	19	high	high	ADJ
bam-7218	623	20	enough	enough	ADV
bam-7218	623	21	to	to	PART
bam-7218	623	22	allow	allow	VERB
bam-7218	623	23	functional	functional	ADJ
bam-7218	623	24	improvements	improvement	NOUN
bam-7218	623	25	.	.	PUNCT
bam-7218	624	1	first	first	ADV
bam-7218	624	2	of	of	ADP
bam-7218	624	3	all	all	PRON
bam-7218	624	4	,	,	PUNCT
bam-7218	624	5	mips	mips	PROPN
bam-7218	624	6	are	be	AUX
bam-7218	624	7	obtained	obtain	VERB
bam-7218	624	8	through	through	ADP
bam-7218	624	9	the	the	DET
bam-7218	624	10	formation	formation	NOUN
bam-7218	624	11	of	of	ADP
bam-7218	624	12	embryoid	embryoid	NOUN
bam-7218	624	13	bodies	body	NOUN
bam-7218	624	14	using	use	VERB
bam-7218	624	15	serumcontaining	serumcontaine	VERB
bam-7218	624	16	media	medium	NOUN
bam-7218	624	17	thereby	thereby	ADV
bam-7218	624	18	limiting	limit	VERB
bam-7218	624	19	their	their	PRON
bam-7218	624	20	clinical	clinical	ADJ
bam-7218	624	21	translatability	translatability	NOUN
bam-7218	624	22	.	.	PUNCT
bam-7218	625	1	secondly	secondly	ADV
bam-7218	625	2	,	,	PUNCT
bam-7218	625	3	although	although	SCONJ
bam-7218	625	4	mips	mips	PROPN
bam-7218	625	5	showed	show	VERB
bam-7218	625	6	to	to	PART
bam-7218	625	7	contribute	contribute	VERB
bam-7218	625	8	to	to	ADP
bam-7218	625	9	both	both	CCONJ
bam-7218	625	10	cardiac	cardiac	ADJ
bam-7218	625	11	and	and	CCONJ
bam-7218	625	12	skeletal	skeletal	ADJ
bam-7218	625	13	muscle	muscle	NOUN
bam-7218	625	14	,	,	PUNCT
bam-7218	625	15	functional	functional	ADJ
bam-7218	625	16	improvement	improvement	NOUN
bam-7218	625	17	was	be	AUX
bam-7218	625	18	only	only	ADV
bam-7218	625	19	moderate	moderate	ADJ
bam-7218	625	20	.	.	PUNCT
bam-7218	626	1	for	for	ADP
bam-7218	626	2	this	this	DET
bam-7218	626	3	study	study	NOUN
bam-7218	626	4	,	,	PUNCT
bam-7218	626	5	a	a	DET
bam-7218	626	6	serum	serum	NOUN
bam-7218	626	7	-	-	PUNCT
bam-7218	626	8	free	free	ADJ
bam-7218	626	9	monolayer	monolayer	NOUN
bam-7218	626	10	approach	approach	NOUN
bam-7218	626	11	,	,	PUNCT
bam-7218	626	12	adapted	adapt	VERB
bam-7218	626	13	from	from	ADP
bam-7218	626	14	shelton	shelton	PROPN
bam-7218	626	15	et	et	PROPN
bam-7218	626	16	al	al	PROPN
bam-7218	626	17	.	.	PROPN
bam-7218	627	1	(	(	PUNCT
bam-7218	627	2	2014	2014	NUM
bam-7218	627	3	)	)	PUNCT
bam-7218	627	4	,	,	PUNCT
bam-7218	627	5	was	be	AUX
bam-7218	627	6	used	use	VERB
bam-7218	627	7	to	to	PART
bam-7218	627	8	derive	derive	VERB
bam-7218	627	9	mesodermal	mesodermal	ADJ
bam-7218	627	10	progenitors	progenitor	NOUN
bam-7218	627	11	from	from	ADP
bam-7218	627	12	induced	induced	ADJ
bam-7218	627	13	pscs	psc	NOUN
bam-7218	627	14	in	in	ADP
bam-7218	627	15	a	a	DET
bam-7218	627	16	clinical	clinical	ADJ
bam-7218	627	17	relevant	relevant	ADJ
bam-7218	627	18	manner2	manner2	NOUN
bam-7218	627	19	.	.	PUNCT
bam-7218	628	1	these	these	DET
bam-7218	628	2	progenitors	progenitor	NOUN
bam-7218	628	3	were	be	AUX
bam-7218	628	4	tested	test	VERB
bam-7218	628	5	in	in	ADP
bam-7218	628	6	vitro	vitro	X
bam-7218	628	7	for	for	ADP
bam-7218	628	8	their	their	PRON
bam-7218	628	9	potential	potential	NOUN
bam-7218	628	10	to	to	PART
bam-7218	628	11	contribute	contribute	VERB
bam-7218	628	12	to	to	ADP
bam-7218	628	13	the	the	DET
bam-7218	628	14	myogenic	myogenic	ADJ
bam-7218	628	15	lineages	lineage	NOUN
bam-7218	628	16	.	.	PUNCT
bam-7218	629	1	next	next	ADV
bam-7218	629	2	,	,	PUNCT
bam-7218	629	3	in	in	ADP
bam-7218	629	4	order	order	NOUN
bam-7218	629	5	to	to	PART
bam-7218	629	6	further	far	ADV
bam-7218	629	7	enhance	enhance	VERB
bam-7218	629	8	their	their	PRON
bam-7218	629	9	myogenic	myogenic	ADJ
bam-7218	629	10	capacity	capacity	NOUN
bam-7218	629	11	and	and	CCONJ
bam-7218	629	12	later	later	ADJ
bam-7218	629	13	engraftment	engraftment	NOUN
bam-7218	629	14	,	,	PUNCT
bam-7218	629	15	stimulation	stimulation	NOUN
bam-7218	629	16	of	of	ADP
bam-7218	629	17	the	the	DET
bam-7218	629	18	dll1	dll1	NOUN
bam-7218	629	19	/	/	SYM
bam-7218	629	20	notch1	notch1	NOUN
bam-7218	629	21	signaling	signal	VERB
bam-7218	629	22	pathway	pathway	NOUN
bam-7218	629	23	is	be	AUX
bam-7218	629	24	being	be	AUX
bam-7218	629	25	explored	explore	VERB
bam-7218	629	26	as	as	SCONJ
bam-7218	629	27	this	this	PRON
bam-7218	629	28	has	have	AUX
bam-7218	629	29	been	be	AUX
bam-7218	629	30	shown	show	VERB
bam-7218	629	31	to	to	PART
bam-7218	629	32	promote	promote	VERB
bam-7218	629	33	the	the	DET
bam-7218	629	34	myogenic	myogenic	ADJ
bam-7218	629	35	commitment	commitment	NOUN
bam-7218	629	36	of	of	ADP
bam-7218	629	37	adult	adult	NOUN
bam-7218	629	38	stem	stem	NOUN
bam-7218	629	39	cells3	cells3	NOUN
bam-7218	629	40	.	.	PUNCT
bam-7218	630	1	with	with	ADP
bam-7218	630	2	the	the	DET
bam-7218	630	3	purpose	purpose	NOUN
bam-7218	630	4	of	of	ADP
bam-7218	630	5	cell	cell	NOUN
bam-7218	630	6	therapy	therapy	NOUN
bam-7218	630	7	in	in	ADP
bam-7218	630	8	mind	mind	NOUN
bam-7218	630	9	,	,	PUNCT
bam-7218	630	10	two	two	NUM
bam-7218	630	11	small	small	ADJ
bam-7218	630	12	molecules	molecule	NOUN
bam-7218	630	13	,	,	PUNCT
bam-7218	630	14	namely	namely	ADV
bam-7218	630	15	valproic	valproic	ADJ
bam-7218	630	16	acid	acid	NOUN
bam-7218	630	17	and	and	CCONJ
bam-7218	630	18	resveratrol	resveratrol	NOUN
bam-7218	630	19	,	,	PUNCT
bam-7218	630	20	are	be	AUX
bam-7218	630	21	being	be	AUX
bam-7218	630	22	investigated	investigate	VERB
bam-7218	630	23	for	for	ADP
bam-7218	630	24	their	their	PRON
bam-7218	630	25	potential	potential	NOUN
bam-7218	630	26	to	to	PART
bam-7218	630	27	improve	improve	VERB
bam-7218	630	28	the	the	DET
bam-7218	630	29	myogenic	myogenic	ADJ
bam-7218	630	30	capacity	capacity	NOUN
bam-7218	630	31	of	of	ADP
bam-7218	630	32	the	the	DET
bam-7218	630	33	obtained	obtain	VERB
bam-7218	630	34	mesodermal	mesodermal	ADJ
bam-7218	630	35	progenitors	progenitor	NOUN
bam-7218	630	36	and	and	CCONJ
bam-7218	630	37	whether	whether	SCONJ
bam-7218	630	38	this	this	DET
bam-7218	630	39	effect	effect	NOUN
bam-7218	630	40	can	can	AUX
bam-7218	630	41	be	be	AUX
bam-7218	630	42	attributed	attribute	VERB
bam-7218	630	43	to	to	ADP
bam-7218	630	44	the	the	DET
bam-7218	630	45	stimulation	stimulation	NOUN
bam-7218	630	46	of	of	ADP
bam-7218	630	47	the	the	DET
bam-7218	630	48	dll1	dll1	NOUN
bam-7218	630	49	/	/	SYM
bam-7218	630	50	notch1	notch1	NOUN
bam-7218	630	51	pathway	pathway	NOUN
bam-7218	630	52	.	.	PUNCT
bam-7218	631	1	references	reference	NOUN
bam-7218	631	2	:	:	PUNCT
bam-7218	631	3	quattrocelli	quattrocelli	PROPN
bam-7218	631	4	,	,	PUNCT
bam-7218	631	5	m.	m.	NOUN
bam-7218	631	6	et	et	PROPN
bam-7218	631	7	al	al	PROPN
bam-7218	631	8	.	.	PROPN
bam-7218	632	1	mesodermal	mesodermal	ADJ
bam-7218	632	2	ipsc	ipsc	NOUN
bam-7218	632	3	-	-	PUNCT
bam-7218	632	4	derived	derive	VERB
bam-7218	632	5	progenitor	progenitor	NOUN
bam-7218	632	6	cells	cell	NOUN
bam-7218	632	7	functionally	functionally	ADV
bam-7218	632	8	regenerate	regenerate	VERB
bam-7218	632	9	cardiac	cardiac	ADJ
bam-7218	632	10	and	and	CCONJ
bam-7218	632	11	skeletal	skeletal	ADJ
bam-7218	632	12	muscle	muscle	NOUN
bam-7218	632	13	.	.	PUNCT
bam-7218	633	1	j.	j.	PROPN
bam-7218	633	2	clin	clin	PROPN
bam-7218	633	3	.	.	PUNCT
bam-7218	634	1	invest	invest	VERB
bam-7218	634	2	.	.	PUNCT
bam-7218	635	1	125	125	NUM
bam-7218	635	2	,	,	PUNCT
bam-7218	635	3	4463–82	4463–82	NUM
bam-7218	635	4	(	(	PUNCT
bam-7218	635	5	2015	2015	NUM
bam-7218	635	6	)	)	PUNCT
bam-7218	635	7	.	.	PUNCT
bam-7218	635	8	
	
	SPACE
bam-7218	636	1	2	2	NUM
bam-7218	636	2	.	.	X
bam-7218	636	3	shelton	shelton	PROPN
bam-7218	636	4	,	,	PUNCT
bam-7218	636	5	m.	m.	NOUN
bam-7218	636	6	,	,	PUNCT
bam-7218	636	7	kocharyan	kocharyan	PROPN
bam-7218	636	8	,	,	PUNCT
bam-7218	636	9	a.	a.	PROPN
bam-7218	636	10	,	,	PUNCT
bam-7218	636	11	liu	liu	PROPN
bam-7218	636	12	,	,	PUNCT
bam-7218	636	13	j.	j.	PROPN
bam-7218	636	14	&	&	CCONJ
bam-7218	636	15	skerjanc	skerjanc	PROPN
bam-7218	636	16	,	,	PUNCT
bam-7218	636	17	i.	i.	PROPN
bam-7218	636	18	s.	s.	PROPN
bam-7218	636	19	robust	robust	ADJ
bam-7218	636	20	generation	generation	NOUN
bam-7218	636	21	and	and	CCONJ
bam-7218	636	22	expansion	expansion	NOUN
bam-7218	636	23	of	of	ADP
bam-7218	636	24	skeletal	skeletal	ADJ
bam-7218	636	25	muscle	muscle	NOUN
bam-7218	636	26	progenitors	progenitor	NOUN
bam-7218	636	27	and	and	CCONJ
bam-7218	636	28	myocytes	myocyte	NOUN
bam-7218	636	29	from	from	ADP
bam-7218	636	30	human	human	ADJ
bam-7218	636	31	pluripotent	pluripotent	NOUN
bam-7218	636	32	stem	stem	NOUN
bam-7218	636	33	cells	cell	NOUN
bam-7218	636	34	.	.	PUNCT
bam-7218	637	1	methods	method	NOUN
bam-7218	637	2	101	101	NUM
bam-7218	637	3	,	,	PUNCT
bam-7218	637	4	73–84	73–84	NOUN
bam-7218	637	5	(	(	PUNCT
bam-7218	637	6	2016	2016	NUM
bam-7218	637	7	)	)	PUNCT
bam-7218	637	8	.	.	PUNCT
bam-7218	638	1	3	3	X
bam-7218	638	2	.	.	X
bam-7218	638	3	quattrocelli	quattrocelli	PROPN
bam-7218	638	4	,	,	PUNCT
bam-7218	638	5	m.	m.	NOUN
bam-7218	638	6	,	,	PUNCT
bam-7218	638	7	costamagna	costamagna	PROPN
bam-7218	638	8	,	,	PUNCT
bam-7218	638	9	d.	d.	PROPN
bam-7218	638	10	,	,	PUNCT
bam-7218	638	11	giacomazzi	giacomazzi	PROPN
bam-7218	638	12	,	,	PUNCT
bam-7218	638	13	g.	g.	PROPN
bam-7218	638	14	,	,	PUNCT
bam-7218	638	15	camps	camp	NOUN
bam-7218	638	16	,	,	PUNCT
bam-7218	638	17	j.	j.	PROPN
bam-7218	638	18	&	&	CCONJ
bam-7218	638	19	sampaolesi	sampaolesi	PROPN
bam-7218	638	20	,	,	PUNCT
bam-7218	638	21	m.	m.	NOUN
bam-7218	638	22	notch	notch	NOUN
bam-7218	638	23	signaling	signal	VERB
bam-7218	638	24	regulates	regulate	VERB
bam-7218	638	25	myogenic	myogenic	ADJ
bam-7218	638	26	regenerative	regenerative	ADJ
bam-7218	638	27	capacity	capacity	NOUN
bam-7218	638	28	of	of	ADP
bam-7218	638	29	murine	murine	ADJ
bam-7218	638	30	and	and	CCONJ
bam-7218	638	31	human	human	ADJ
bam-7218	638	32	mesoangioblasts	mesoangioblast	NOUN
bam-7218	638	33	.	.	PUNCT
bam-7218	639	1	cell	cell	NOUN
bam-7218	639	2	death	death	NOUN
bam-7218	640	1	dis	dis	PROPN
bam-7218	640	2	.	.	PUNCT
bam-7218	641	1	5	5	NUM
bam-7218	641	2	,	,	PUNCT
bam-7218	641	3	e1448	e1448	X
bam-7218	641	4	(	(	PUNCT
bam-7218	641	5	2014	2014	NUM
bam-7218	641	6	)	)	PUNCT
bam-7218	641	7	.	.	PUNCT
bam-7218	642	1	6.3	6.3	NUM
bam-7218	642	2	sarcoglycanopathy	sarcoglycanopathy	NOUN
bam-7218	642	3	:	:	PUNCT
bam-7218	642	4	from	from	ADP
bam-7218	642	5	the	the	DET
bam-7218	642	6	molecular	molecular	ADJ
bam-7218	642	7	mechanism	mechanism	NOUN
bam-7218	642	8	to	to	ADP
bam-7218	642	9	new	new	ADJ
bam-7218	642	10	therapeutic	therapeutic	ADJ
bam-7218	642	11	perspectives	perspective	NOUN
bam-7218	642	12	chiara	chiara	X
bam-7218	642	13	fecchio	fecchio	PROPN
bam-7218	642	14	,	,	PUNCT
bam-7218	642	15	marcello	marcello	PROPN
bam-7218	642	16	carotti	carotti	PROPN
bam-7218	642	17	,	,	PUNCT
bam-7218	642	18	michela	michela	PROPN
bam-7218	642	19	soardi	soardi	PROPN
bam-7218	642	20	,	,	PUNCT
bam-7218	642	21	valerio	valerio	PROPN
bam-7218	642	22	gobbo	gobbo	PROPN
bam-7218	642	23	,	,	PUNCT
bam-7218	642	24	elena	elena	PROPN
bam-7218	642	25	germinario	germinario	PROPN
bam-7218	642	26	,	,	PUNCT
bam-7218	642	27	dorianna	dorianna	PROPN
bam-7218	642	28	sandonà	sandonà	PROPN
bam-7218	642	29	dept	dept	NOUN
bam-7218	642	30	of	of	ADP
bam-7218	642	31	biomedical	biomedical	ADJ
bam-7218	642	32	sciences	sciences	PROPN
bam-7218	642	33	,	,	PUNCT
bam-7218	642	34	university	university	NOUN
bam-7218	642	35	of	of	ADP
bam-7218	642	36	padova	padova	PROPN
bam-7218	642	37	,	,	PUNCT
bam-7218	642	38	italy	italy	PROPN
bam-7218	642	39	.	.	PUNCT
bam-7218	643	1	e	e	X
bam-7218	643	2	-	-	NOUN
bam-7218	643	3	mail	mail	NOUN
bam-7218	643	4	:	:	PUNCT
bam-7218	643	5	chiara.fecchio@bio.unipd.it	chiara.fecchio@bio.unipd.it	DET
bam-7218	643	6	sarcoglycanopathy	sarcoglycanopathy	NOUN
bam-7218	643	7	is	be	AUX
bam-7218	643	8	caused	cause	VERB
bam-7218	643	9	by	by	ADP
bam-7218	643	10	mutations	mutation	NOUN
bam-7218	643	11	in	in	ADP
bam-7218	643	12	sarcoglycans	sarcoglycan	NOUN
bam-7218	643	13	(	(	PUNCT
bam-7218	643	14	sg	sg	PROPN
bam-7218	643	15	)	)	PUNCT
bam-7218	643	16	,	,	PUNCT
bam-7218	643	17	four	four	NUM
bam-7218	643	18	glycoproteins	glycoprotein	NOUN
bam-7218	643	19	that	that	PRON
bam-7218	643	20	form	form	VERB
bam-7218	643	21	an	an	DET
bam-7218	643	22	essential	essential	ADJ
bam-7218	643	23	complex	complex	NOUN
bam-7218	643	24	for	for	ADP
bam-7218	643	25	the	the	DET
bam-7218	643	26	integrity	integrity	NOUN
bam-7218	643	27	of	of	ADP
bam-7218	643	28	muscle	muscle	NOUN
bam-7218	643	29	cells	cell	NOUN
bam-7218	643	30	.	.	PUNCT
bam-7218	644	1	most	most	ADJ
bam-7218	644	2	sarcoglycan	sarcoglycan	ADJ
bam-7218	644	3	mutations	mutation	NOUN
bam-7218	644	4	are	be	AUX
bam-7218	644	5	missense	missense	NOUN
bam-7218	644	6	mutations	mutation	NOUN
bam-7218	644	7	generating	generate	VERB
bam-7218	644	8	a	a	DET
bam-7218	644	9	folding	folding	ADJ
bam-7218	644	10	defective	defective	ADJ
bam-7218	644	11	protein	protein	NOUN
bam-7218	644	12	,	,	PUNCT
bam-7218	644	13	which	which	PRON
bam-7218	644	14	is	be	AUX
bam-7218	644	15	prematurely	prematurely	ADV
bam-7218	644	16	degraded	degrade	VERB
bam-7218	644	17	by	by	ADP
bam-7218	644	18	the	the	DET
bam-7218	644	19	cell	cell	NOUN
bam-7218	644	20	’s	’s	PART
bam-7218	644	21	quality	quality	NOUN
bam-7218	644	22	control	control	NOUN
bam-7218	644	23	.	.	PUNCT
bam-7218	645	1	we	we	PRON
bam-7218	645	2	recently	recently	ADV
bam-7218	645	3	unveiled	unveil	VERB
bam-7218	645	4	the	the	DET
bam-7218	645	5	pathway	pathway	NOUN
bam-7218	645	6	responsible	responsible	ADJ
bam-7218	645	7	for	for	ADP
bam-7218	645	8	the	the	DET
bam-7218	645	9	disposal	disposal	NOUN
bam-7218	645	10	of	of	ADP
bam-7218	645	11	defective	defective	ADJ
bam-7218	645	12	alpha	alpha	NOUN
bam-7218	645	13	-	-	PUNCT
bam-7218	645	14	sg	sg	PROPN
bam-7218	645	15	and	and	CCONJ
bam-7218	645	16	demonstrated	demonstrate	VERB
bam-7218	645	17	that	that	SCONJ
bam-7218	645	18	many	many	ADJ
bam-7218	645	19	missense	missense	NOUN
bam-7218	645	20	mutants	mutant	NOUN
bam-7218	645	21	retain	retain	VERB
bam-7218	645	22	their	their	PRON
bam-7218	645	23	function	function	NOUN
bam-7218	645	24	.	.	PUNCT
bam-7218	646	1	indeed	indeed	ADV
bam-7218	646	2	,	,	PUNCT
bam-7218	646	3	the	the	DET
bam-7218	646	4	complex	complex	NOUN
bam-7218	646	5	can	can	AUX
bam-7218	646	6	be	be	AUX
bam-7218	646	7	properly	properly	ADV
bam-7218	646	8	rescued	rescue	VERB
bam-7218	646	9	by	by	ADP
bam-7218	646	10	targeting	target	VERB
bam-7218	646	11	the	the	DET
bam-7218	646	12	degradative	degradative	ADJ
bam-7218	646	13	pathway	pathway	NOUN
bam-7218	646	14	.	.	PUNCT
bam-7218	647	1	thanks	thank	NOUN
bam-7218	647	2	to	to	ADP
bam-7218	647	3	these	these	DET
bam-7218	647	4	knowledges	knowledge	NOUN
bam-7218	647	5	,	,	PUNCT
bam-7218	647	6	we	we	PRON
bam-7218	647	7	design	design	VERB
bam-7218	647	8	a	a	DET
bam-7218	647	9	novel	novel	ADJ
bam-7218	647	10	therapeutic	therapeutic	ADJ
bam-7218	647	11	approach	approach	NOUN
bam-7218	647	12	for	for	ADP
bam-7218	647	13	sarcoglycanopathy	sarcoglycanopathy	NOUN
bam-7218	647	14	based	base	VERB
bam-7218	647	15	on	on	ADP
bam-7218	647	16	the	the	DET
bam-7218	647	17	use	use	NOUN
bam-7218	647	18	of	of	ADP
bam-7218	647	19	small	small	ADJ
bam-7218	647	20	molecules	molecule	NOUN
bam-7218	647	21	able	able	ADJ
bam-7218	647	22	to	to	PART
bam-7218	647	23	improve	improve	VERB
bam-7218	647	24	the	the	DET
bam-7218	647	25	folding	fold	VERB
bam-7218	647	26	process	process	NOUN
bam-7218	647	27	of	of	ADP
bam-7218	647	28	defective	defective	ADJ
bam-7218	647	29	sarcoglycans	sarcoglycan	NOUN
bam-7218	647	30	.	.	PUNCT
bam-7218	648	1	once	once	ADV
bam-7218	648	2	structurally	structurally	ADV
bam-7218	648	3	stabilized	stabilize	VERB
bam-7218	648	4	,	,	PUNCT
bam-7218	648	5	they	they	PRON
bam-7218	648	6	can	can	AUX
bam-7218	648	7	skip	skip	VERB
bam-7218	648	8	disposal	disposal	NOUN
bam-7218	648	9	and	and	CCONJ
bam-7218	648	10	traffic	traffic	NOUN
bam-7218	648	11	at	at	ADP
bam-7218	648	12	the	the	DET
bam-7218	648	13	proper	proper	ADJ
bam-7218	648	14	site	site	NOUN
bam-7218	648	15	of	of	ADP
bam-7218	648	16	action	action	NOUN
bam-7218	648	17	.	.	PUNCT
bam-7218	649	1	to	to	ADP
bam-7218	649	2	this	this	DET
bam-7218	649	3	intent	intent	NOUN
bam-7218	649	4	,	,	PUNCT
bam-7218	649	5	we	we	PRON
bam-7218	649	6	tested	test	VERB
bam-7218	649	7	compounds	compound	NOUN
bam-7218	649	8	of	of	ADP
bam-7218	649	9	the	the	DET
bam-7218	649	10	library	library	NOUN
bam-7218	649	11	of	of	ADP
bam-7218	649	12	the	the	DET
bam-7218	649	13	cftr	cftr	NOUN
bam-7218	649	14	mailto:natacha.breuls@kuleuven.be	mailto:natacha.breuls@kuleuven.be	PROPN
bam-7218	649	15	mailto:chiara.fecchio@bio.unipd.it	mailto:chiara.fecchio@bio.unipd.it	NUM
bam-7218	649	16	14	14	NUM
bam-7218	649	17	th	th	NUM
bam-7218	649	18	iiim	iiim	NOUN
bam-7218	649	19	meeting	meeting	NOUN
bam-7218	649	20	,	,	PUNCT
bam-7218	649	21	assisi	assisi	PROPN
bam-7218	649	22	,	,	PUNCT
bam-7218	649	23	italy	italy	PROPN
bam-7218	649	24	october	october	PROPN
bam-7218	649	25	12	12	NUM
bam-7218	649	26	-	-	SYM
bam-7218	649	27	15	15	NUM
bam-7218	649	28	2017	2017	NUM
bam-7218	649	29	eur	eur	PROPN
bam-7218	649	30	j	j	PROPN
bam-7218	649	31	transl	transl	PROPN
bam-7218	649	32	myol	myol	ADV
bam-7218	649	33	27	27	NUM
bam-7218	649	34	(	(	PUNCT
bam-7218	649	35	4	4	NUM
bam-7218	649	36	):	):	SYM
bam-7218	649	37	185	185	NUM
bam-7218	649	38	-	-	SYM
bam-7218	649	39	224	224	NUM
bam-7218	649	40	204	204	NUM
bam-7218	649	41	correctors	corrector	NOUN
bam-7218	649	42	and	and	CCONJ
bam-7218	649	43	several	several	ADJ
bam-7218	649	44	of	of	ADP
bam-7218	649	45	them	they	PRON
bam-7218	649	46	were	be	AUX
bam-7218	649	47	effective	effective	ADJ
bam-7218	649	48	in	in	ADP
bam-7218	649	49	rescuing	rescue	VERB
bam-7218	649	50	sg	sg	ADP
bam-7218	649	51	mutants	mutant	NOUN
bam-7218	649	52	in	in	ADP
bam-7218	649	53	cell	cell	NOUN
bam-7218	649	54	models	model	NOUN
bam-7218	649	55	and	and	CCONJ
bam-7218	649	56	,	,	PUNCT
bam-7218	649	57	notably	notably	ADV
bam-7218	649	58	,	,	PUNCT
bam-7218	649	59	in	in	ADP
bam-7218	649	60	myotubes	myotube	NOUN
bam-7218	649	61	from	from	ADP
bam-7218	649	62	a	a	DET
bam-7218	649	63	patient	patient	NOUN
bam-7218	649	64	with	with	ADP
bam-7218	649	65	alpha	alpha	NOUN
bam-7218	649	66	-	-	PUNCT
bam-7218	649	67	sarcoglycanopathy	sarcoglycanopathy	NOUN
bam-7218	649	68	.	.	PUNCT
bam-7218	650	1	although	although	SCONJ
bam-7218	650	2	we	we	PRON
bam-7218	650	3	need	need	VERB
bam-7218	650	4	to	to	PART
bam-7218	650	5	clarify	clarify	VERB
bam-7218	650	6	the	the	DET
bam-7218	650	7	mechanism	mechanism	NOUN
bam-7218	650	8	by	by	ADP
bam-7218	650	9	which	which	PRON
bam-7218	650	10	cftr	cftr	NOUN
bam-7218	650	11	correctors	corrector	NOUN
bam-7218	650	12	exert	exert	VERB
bam-7218	650	13	their	their	PRON
bam-7218	650	14	activity	activity	NOUN
bam-7218	650	15	in	in	ADP
bam-7218	650	16	sarcoglycanopathy	sarcoglycanopathy	NOUN
bam-7218	650	17	,	,	PUNCT
bam-7218	650	18	these	these	DET
bam-7218	650	19	data	datum	NOUN
bam-7218	650	20	represent	represent	VERB
bam-7218	650	21	the	the	DET
bam-7218	650	22	proof	proof	NOUN
bam-7218	650	23	of	of	ADP
bam-7218	650	24	principle	principle	NOUN
bam-7218	650	25	of	of	ADP
bam-7218	650	26	a	a	DET
bam-7218	650	27	novel	novel	ADJ
bam-7218	650	28	pharmacological	pharmacological	NOUN
bam-7218	650	29	strategy	strategy	NOUN
bam-7218	650	30	for	for	ADP
bam-7218	650	31	this	this	PRON
bam-7218	650	32	,	,	PUNCT
bam-7218	650	33	still	still	ADV
bam-7218	650	34	incurable	incurable	ADJ
bam-7218	650	35	,	,	PUNCT
bam-7218	650	36	disease	disease	NOUN
bam-7218	650	37	.	.	PUNCT
bam-7218	651	1	now	now	ADV
bam-7218	651	2	we	we	PRON
bam-7218	651	3	are	be	AUX
bam-7218	651	4	focused	focus	VERB
bam-7218	651	5	on	on	ADP
bam-7218	651	6	the	the	DET
bam-7218	651	7	development	development	NOUN
bam-7218	651	8	of	of	ADP
bam-7218	651	9	unconventional	unconventional	ADJ
bam-7218	651	10	animal	animal	NOUN
bam-7218	651	11	models	model	NOUN
bam-7218	651	12	for	for	ADP
bam-7218	651	13	in	in	ADP
bam-7218	651	14	vivo	vivo	ADJ
bam-7218	651	15	studies	study	NOUN
bam-7218	651	16	,	,	PUNCT
bam-7218	651	17	essential	essential	ADJ
bam-7218	651	18	to	to	PART
bam-7218	651	19	confirm	confirm	VERB
bam-7218	651	20	efficacy	efficacy	NOUN
bam-7218	651	21	as	as	ADV
bam-7218	651	22	well	well	ADV
bam-7218	651	23	as	as	ADP
bam-7218	651	24	safety	safety	NOUN
bam-7218	651	25	and	and	CCONJ
bam-7218	651	26	tolerability	tolerability	NOUN
bam-7218	651	27	of	of	ADP
bam-7218	651	28	these	these	DET
bam-7218	651	29	compounds	compound	NOUN
bam-7218	651	30	.	.	PUNCT
bam-7218	652	1	at	at	ADP
bam-7218	652	2	present	present	ADJ
bam-7218	652	3	,	,	PUNCT
bam-7218	652	4	we	we	PRON
bam-7218	652	5	are	be	AUX
bam-7218	652	6	characterizing	characterize	VERB
bam-7218	652	7	at	at	ADP
bam-7218	652	8	the	the	DET
bam-7218	652	9	histological	histological	ADJ
bam-7218	652	10	and	and	CCONJ
bam-7218	652	11	molecular	molecular	ADJ
bam-7218	652	12	level	level	NOUN
bam-7218	652	13	,	,	PUNCT
bam-7218	652	14	mouse	mouse	NOUN
bam-7218	652	15	models	model	NOUN
bam-7218	652	16	obtained	obtain	VERB
bam-7218	652	17	by	by	ADP
bam-7218	652	18	the	the	DET
bam-7218	652	19	aav	aav	NOUN
bam-7218	652	20	-	-	PUNCT
bam-7218	652	21	mediated	mediate	VERB
bam-7218	652	22	gene	gene	NOUN
bam-7218	652	23	delivery	delivery	NOUN
bam-7218	652	24	of	of	ADP
bam-7218	652	25	mutated	mutate	VERB
bam-7218	652	26	versions	version	NOUN
bam-7218	652	27	of	of	ADP
bam-7218	652	28	the	the	DET
bam-7218	652	29	human	human	ADJ
bam-7218	652	30	sequence	sequence	NOUN
bam-7218	652	31	in	in	ADP
bam-7218	652	32	the	the	DET
bam-7218	652	33	null	null	ADJ
bam-7218	652	34	alpha	alpha	PROPN
bam-7218	652	35	-	-	PUNCT
bam-7218	652	36	sg	sg	PROPN
bam-7218	652	37	background	background	NOUN
bam-7218	652	38	.	.	PUNCT
bam-7218	653	1	6.4	6.4	NUM
bam-7218	653	2	human	human	ADJ
bam-7218	653	3	dental	dental	ADJ
bam-7218	653	4	pulp	pulp	NOUN
bam-7218	653	5	pluripotent	pluripotent	NOUN
bam-7218	653	6	-	-	PUNCT
bam-7218	653	7	like	like	ADJ
bam-7218	653	8	stem	stem	NOUN
bam-7218	653	9	cells	cell	NOUN
bam-7218	653	10	promote	promote	VERB
bam-7218	653	11	tissue	tissue	NOUN
bam-7218	653	12	regeneration	regeneration	NOUN
bam-7218	653	13	through	through	ADP
bam-7218	653	14	paracrine	paracrine	NOUN
bam-7218	653	15	signaling	signal	VERB
bam-7218	653	16	and	and	CCONJ
bam-7218	653	17	direct	direct	ADJ
bam-7218	653	18	contribution	contribution	NOUN
bam-7218	653	19	ester	ester	NOUN
bam-7218	653	20	martínez	martínez	PROPN
bam-7218	653	21	-	-	PUNCT
bam-7218	653	22	sarrà	sarrà	PROPN
bam-7218	653	23	(	(	PUNCT
bam-7218	653	24	a	a	DET
bam-7218	653	25	,	,	PUNCT
bam-7218	653	26	b	b	NOUN
bam-7218	653	27	)	)	PUNCT
bam-7218	653	28	,	,	PUNCT
bam-7218	653	29	sheyla	sheyla	NOUN
bam-7218	653	30	montori	montori	NOUN
bam-7218	653	31	(	(	PUNCT
bam-7218	653	32	b	b	NOUN
bam-7218	653	33	)	)	PUNCT
bam-7218	653	34	,	,	PUNCT
bam-7218	653	35	carlos	carlos	PROPN
bam-7218	653	36	gil	gil	PROPN
bam-7218	653	37	-	-	PUNCT
bam-7218	653	38	recio	recio	PROPN
bam-7218	653	39	(	(	PUNCT
bam-7218	653	40	b	b	NOUN
bam-7218	653	41	)	)	PUNCT
bam-7218	653	42	,	,	PUNCT
bam-7218	653	43	raquel	raquel	PROPN
bam-7218	653	44	núñez	núñez	PROPN
bam-7218	653	45	-	-	PUNCT
bam-7218	653	46	toldrà	toldrà	NOUN
bam-7218	653	47	(	(	PUNCT
bam-7218	653	48	b	b	NOUN
bam-7218	653	49	)	)	PUNCT
bam-7218	653	50	,	,	PUNCT
bam-7218	653	51	domiziana	domiziana	PROPN
bam-7218	653	52	costamagna	costamagna	NOUN
bam-7218	653	53	(	(	PUNCT
bam-7218	653	54	a	a	DET
bam-7218	653	55	,	,	PUNCT
bam-7218	653	56	c	c	NOUN
bam-7218	653	57	)	)	PUNCT
bam-7218	653	58	,	,	PUNCT
bam-7218	653	59	alessio	alessio	PROPN
bam-7218	653	60	rotini	rotini	X
bam-7218	653	61	(	(	PUNCT
bam-7218	653	62	a	a	DET
bam-7218	653	63	,	,	PUNCT
bam-7218	653	64	d	d	NOUN
bam-7218	653	65	)	)	PUNCT
bam-7218	653	66	,	,	PUNCT
bam-7218	653	67	maher	maher	PROPN
bam-7218	653	68	atari	atari	PROPN
bam-7218	653	69	(	(	PUNCT
bam-7218	653	70	b	b	NOUN
bam-7218	653	71	)	)	PUNCT
bam-7218	653	72	,	,	PUNCT
bam-7218	653	73	aernout	aernout	NOUN
bam-7218	653	74	luttun	luttun	PROPN
bam-7218	653	75	(	(	PUNCT
bam-7218	653	76	e	e	NOUN
bam-7218	653	77	)	)	PUNCT
bam-7218	653	78	,	,	PUNCT
bam-7218	653	79	maurilio	maurilio	NOUN
bam-7218	653	80	sampaolesi	sampaolesi	NOUN
bam-7218	653	81	(	(	PUNCT
bam-7218	653	82	a	a	DET
bam-7218	653	83	,	,	PUNCT
bam-7218	653	84	c	c	NOUN
bam-7218	653	85	)	)	PUNCT
bam-7218	653	86	(	(	PUNCT
bam-7218	653	87	a	a	X
bam-7218	653	88	)	)	PUNCT
bam-7218	653	89	translational	translational	ADJ
bam-7218	653	90	cardiomyology	cardiomyology	NOUN
bam-7218	653	91	laboratory	laboratory	NOUN
bam-7218	653	92	,	,	PUNCT
bam-7218	653	93	stem	stem	NOUN
bam-7218	653	94	cell	cell	NOUN
bam-7218	653	95	biology	biology	NOUN
bam-7218	653	96	and	and	CCONJ
bam-7218	653	97	embryology	embryology	NOUN
bam-7218	653	98	unit	unit	NOUN
bam-7218	653	99	,	,	PUNCT
bam-7218	653	100	dept	dept	NOUN
bam-7218	653	101	of	of	ADP
bam-7218	653	102	development	development	NOUN
bam-7218	653	103	and	and	CCONJ
bam-7218	653	104	regeneration	regeneration	NOUN
bam-7218	653	105	,	,	PUNCT
bam-7218	653	106	ku	ku	PROPN
bam-7218	653	107	leuven	leuven	PROPN
bam-7218	653	108	,	,	PUNCT
bam-7218	653	109	leuven	leuven	PROPN
bam-7218	653	110	,	,	PUNCT
bam-7218	653	111	belgium	belgium	NOUN
bam-7218	653	112	;	;	PUNCT
bam-7218	653	113	
	
	SPACE
bam-7218	653	114	(	(	PUNCT
bam-7218	653	115	b	b	NOUN
bam-7218	653	116	)	)	PUNCT
bam-7218	653	117	regenerative	regenerative	ADJ
bam-7218	653	118	medicine	medicine	NOUN
bam-7218	653	119	research	research	PROPN
bam-7218	653	120	institute	institute	PROPN
bam-7218	653	121	,	,	PUNCT
bam-7218	653	122	international	international	PROPN
bam-7218	653	123	university	university	PROPN
bam-7218	653	124	of	of	ADP
bam-7218	653	125	barcelona	barcelona	PROPN
bam-7218	653	126	,	,	PUNCT
bam-7218	653	127	spain	spain	PROPN
bam-7218	653	128	;	;	PUNCT
bam-7218	653	129	(	(	PUNCT
bam-7218	653	130	c	c	X
bam-7218	653	131	)	)	PUNCT
bam-7218	653	132	division	division	NOUN
bam-7218	653	133	of	of	ADP
bam-7218	653	134	human	human	ADJ
bam-7218	653	135	anatomy	anatomy	NOUN
bam-7218	653	136	,	,	PUNCT
bam-7218	653	137	dept	dept	NOUN
bam-7218	653	138	of	of	ADP
bam-7218	653	139	public	public	ADJ
bam-7218	653	140	health	health	NOUN
bam-7218	653	141	,	,	PUNCT
bam-7218	653	142	experimental	experimental	ADJ
bam-7218	653	143	and	and	CCONJ
bam-7218	653	144	forensic	forensic	ADJ
bam-7218	653	145	medicine	medicine	NOUN
bam-7218	653	146	,	,	PUNCT
bam-7218	653	147	university	university	NOUN
bam-7218	653	148	of	of	ADP
bam-7218	653	149	pavia	pavia	PROPN
bam-7218	653	150	,	,	PUNCT
bam-7218	653	151	pavia	pavia	PROPN
bam-7218	653	152	,	,	PUNCT
bam-7218	653	153	italy	italy	PROPN
bam-7218	653	154	;	;	PUNCT
bam-7218	653	155	
 	
 	SPACE
bam-7218	653	156	(	(	PUNCT
bam-7218	653	157	d	d	NOUN
bam-7218	653	158	)	)	PUNCT
bam-7218	653	159	dept	dept	NOUN
bam-7218	653	160	of	of	ADP
bam-7218	653	161	neuroscience	neuroscience	NOUN
bam-7218	653	162	,	,	PUNCT
bam-7218	653	163	imaging	imaging	NOUN
bam-7218	653	164	and	and	CCONJ
bam-7218	653	165	clinical	clinical	ADJ
bam-7218	653	166	sciences	science	NOUN
bam-7218	653	167	,	,	PUNCT
bam-7218	653	168	university	university	NOUN
bam-7218	653	169	“	"	PUNCT
bam-7218	653	170	g.	g.	PROPN
bam-7218	653	171	d’annunzio	d’annunzio	PROPN
bam-7218	653	172	”	"	PUNCT
bam-7218	653	173	chieti	chieti	PROPN
bam-7218	653	174	-	-	PUNCT
bam-7218	653	175	pescara	pescara	PROPN
bam-7218	653	176	;	;	PUNCT
bam-7218	653	177	interuniversity	interuniversity	NOUN
bam-7218	653	178	institute	institute	PROPN
bam-7218	653	179	of	of	ADP
bam-7218	653	180	myology	myology	NOUN
bam-7218	653	181	,	,	PUNCT
bam-7218	653	182	chieti	chieti	PROPN
bam-7218	653	183	,	,	PUNCT
bam-7218	653	184	italy	italy	PROPN
bam-7218	653	185	;	;	PUNCT
bam-7218	653	186	(	(	PUNCT
bam-7218	653	187	e	e	NOUN
bam-7218	653	188	)	)	PUNCT
bam-7218	653	189	centre	centre	NOUN
bam-7218	653	190	for	for	ADP
bam-7218	653	191	molecular	molecular	ADJ
bam-7218	653	192	and	and	CCONJ
bam-7218	653	193	vascular	vascular	ADJ
bam-7218	653	194	biology	biology	NOUN
bam-7218	653	195	,	,	PUNCT
bam-7218	653	196	dept	dept	NOUN
bam-7218	653	197	of	of	ADP
bam-7218	653	198	cardiovascular	cardiovascular	ADJ
bam-7218	653	199	sciences	science	NOUN
bam-7218	653	200	,	,	PUNCT
bam-7218	653	201	ku	ku	PROPN
bam-7218	653	202	leuven	leuven	PROPN
bam-7218	653	203	,	,	PUNCT
bam-7218	653	204	leuven	leuven	PROPN
bam-7218	653	205	,	,	PUNCT
bam-7218	653	206	belgium	belgium	NOUN
bam-7218	653	207	.	.	PUNCT
bam-7218	654	1	e	e	X
bam-7218	654	2	-	-	NOUN
bam-7218	654	3	mail	mail	NOUN
bam-7218	654	4	:	:	PUNCT
bam-7218	654	5	ester.martinezsarra@kuleuven.be	ester.martinezsarra@kuleuven.be	VERB
bam-7218	654	6	dental	dental	ADJ
bam-7218	654	7	pulp	pulp	NOUN
bam-7218	654	8	pluripotent	pluripotent	NOUN
bam-7218	654	9	-	-	PUNCT
bam-7218	654	10	like	like	ADJ
bam-7218	654	11	stem	stem	NOUN
bam-7218	654	12	cells	cell	NOUN
bam-7218	654	13	(	(	PUNCT
bam-7218	654	14	dppsc	dppsc	NOUN
bam-7218	654	15	)	)	PUNCT
bam-7218	654	16	isolated	isolate	VERB
bam-7218	654	17	from	from	ADP
bam-7218	654	18	human	human	PROPN
bam-7218	654	19	third	third	ADJ
bam-7218	654	20	molar	molar	ADJ
bam-7218	654	21	pulp	pulp	NOUN
bam-7218	654	22	express	express	NOUN
bam-7218	654	23	embryonic	embryonic	ADJ
bam-7218	654	24	stem	stem	NOUN
bam-7218	654	25	cell	cell	NOUN
bam-7218	654	26	markers	marker	NOUN
bam-7218	654	27	1	1	NUM
bam-7218	654	28	and	and	CCONJ
bam-7218	654	29	show	show	VERB
bam-7218	654	30	pluripotent	pluripotent	ADJ
bam-7218	654	31	-	-	PUNCT
bam-7218	654	32	like	like	ADJ
bam-7218	654	33	behavior	behavior	NOUN
bam-7218	654	34	,	,	PUNCT
bam-7218	654	35	2	2	NUM
bam-7218	654	36	making	make	VERB
bam-7218	654	37	dppsc	dppsc	NOUN
bam-7218	654	38	an	an	DET
bam-7218	654	39	appealing	appealing	ADJ
bam-7218	654	40	tool	tool	NOUN
bam-7218	654	41	for	for	ADP
bam-7218	654	42	tissue	tissue	NOUN
bam-7218	654	43	repair	repair	NOUN
bam-7218	654	44	or	or	CCONJ
bam-7218	654	45	maintenance	maintenance	NOUN
bam-7218	654	46	.	.	PUNCT
bam-7218	655	1	in	in	ADP
bam-7218	655	2	this	this	DET
bam-7218	655	3	study	study	NOUN
bam-7218	655	4	,	,	PUNCT
bam-7218	655	5	dppsc	dppsc	NOUN
bam-7218	655	6	obtained	obtain	VERB
bam-7218	655	7	from	from	ADP
bam-7218	655	8	young	young	ADJ
bam-7218	655	9	patients	patient	NOUN
bam-7218	655	10	were	be	AUX
bam-7218	655	11	characterized	characterize	VERB
bam-7218	655	12	and	and	CCONJ
bam-7218	655	13	their	their	PRON
bam-7218	655	14	secretome	secretome	NOUN
bam-7218	655	15	was	be	AUX
bam-7218	655	16	analyzed	analyze	VERB
bam-7218	655	17	.	.	PUNCT
bam-7218	656	1	we	we	PRON
bam-7218	656	2	then	then	ADV
bam-7218	656	3	evaluated	evaluate	VERB
bam-7218	656	4	dppsc	dppsc	NOUN
bam-7218	656	5	differentiation	differentiation	NOUN
bam-7218	656	6	potential	potential	NOUN
bam-7218	656	7	towards	towards	ADP
bam-7218	656	8	endothelial	endothelial	NOUN
bam-7218	656	9	,	,	PUNCT
bam-7218	656	10	smooth	smooth	ADJ
bam-7218	656	11	and	and	CCONJ
bam-7218	656	12	skeletal	skeletal	ADJ
bam-7218	656	13	muscle	muscle	NOUN
bam-7218	656	14	lineages	lineage	NOUN
bam-7218	656	15	.	.	PUNCT
bam-7218	657	1	the	the	PRON
bam-7218	657	2	in	in	ADP
bam-7218	657	3	vivo	vivo	ADJ
bam-7218	657	4	contribution	contribution	NOUN
bam-7218	657	5	of	of	ADP
bam-7218	657	6	dppsc	dppsc	NOUN
bam-7218	657	7	was	be	AUX
bam-7218	657	8	tested	test	VERB
bam-7218	657	9	in	in	ADP
bam-7218	657	10	a	a	DET
bam-7218	657	11	wound	wound	NOUN
bam-7218	657	12	-	-	PUNCT
bam-7218	657	13	healing	heal	VERB
bam-7218	657	14	mouse	mouse	NOUN
bam-7218	657	15	model	model	NOUN
bam-7218	657	16	and	and	CCONJ
bam-7218	657	17	in	in	ADP
bam-7218	657	18	two	two	NUM
bam-7218	657	19	immuno	immuno	ADJ
bam-7218	657	20	-	-	PUNCT
bam-7218	657	21	deficient	deficient	ADJ
bam-7218	657	22	mice	mouse	NOUN
bam-7218	657	23	resembling	resemble	VERB
bam-7218	657	24	duchenne	duchenne	ADJ
bam-7218	657	25	muscular	muscular	ADJ
bam-7218	657	26	dystrophy	dystrophy	NOUN
bam-7218	657	27	and	and	CCONJ
bam-7218	657	28	limb	limb	NOUN
bam-7218	657	29	-	-	PUNCT
bam-7218	657	30	girdle	girdle	NOUN
bam-7218	657	31	muscular	muscular	ADJ
bam-7218	657	32	dystrophy	dystrophy	NOUN
bam-7218	657	33	type	type	NOUN
bam-7218	657	34	2e	2e	NOUN
bam-7218	657	35	(	(	PUNCT
bam-7218	657	36	scid	scid	NOUN
bam-7218	657	37	/	/	SYM
bam-7218	657	38	mdx	mdx	PROPN
bam-7218	657	39	and	and	CCONJ
bam-7218	657	40	sgcb	sgcb	NOUN
bam-7218	657	41	-	-	PUNCT
bam-7218	657	42	null	null	NOUN
bam-7218	657	43	rag2	rag2	PROPN
bam-7218	657	44	-	-	PUNCT
bam-7218	657	45	null	null	PROPN
bam-7218	657	46	γc	γc	NOUN
bam-7218	657	47	-	-	NOUN
bam-7218	657	48	null	null	ADJ
bam-7218	657	49	[	[	X
bam-7218	657	50	3	3	NUM
bam-7218	657	51	]	]	PUNCT
bam-7218	657	52	,	,	PUNCT
bam-7218	657	53	respectively	respectively	ADV
bam-7218	657	54	)	)	PUNCT
bam-7218	657	55	.	.	PUNCT
bam-7218	658	1	our	our	PRON
bam-7218	658	2	results	result	NOUN
bam-7218	658	3	showed	show	VERB
bam-7218	658	4	that	that	SCONJ
bam-7218	658	5	dppsc	dppsc	NOUN
bam-7218	658	6	secreted	secrete	VERB
bam-7218	658	7	several	several	ADJ
bam-7218	658	8	growth	growth	NOUN
bam-7218	658	9	factors	factor	NOUN
bam-7218	658	10	involved	involve	VERB
bam-7218	658	11	in	in	ADP
bam-7218	658	12	angiogenesis	angiogenesis	NOUN
bam-7218	658	13	and	and	CCONJ
bam-7218	658	14	extracellular	extracellular	ADJ
bam-7218	658	15	matrix	matrix	NOUN
bam-7218	658	16	deposition	deposition	NOUN
bam-7218	658	17	and	and	CCONJ
bam-7218	658	18	that	that	DET
bam-7218	658	19	dppsc	dppsc	NOUN
bam-7218	658	20	treatment	treatment	NOUN
bam-7218	658	21	improved	improve	VERB
bam-7218	658	22	vascularization	vascularization	NOUN
bam-7218	658	23	in	in	ADP
bam-7218	658	24	all	all	DET
bam-7218	658	25	mouse	mouse	NOUN
bam-7218	658	26	models	model	NOUN
bam-7218	658	27	.	.	PUNCT
bam-7218	659	1	in	in	ADP
bam-7218	659	2	dystrophic	dystrophic	ADJ
bam-7218	659	3	mice	mouse	NOUN
bam-7218	659	4	,	,	PUNCT
bam-7218	659	5	dppsc	dppsc	NOUN
bam-7218	659	6	integrated	integrate	VERB
bam-7218	659	7	in	in	ADP
bam-7218	659	8	muscular	muscular	ADJ
bam-7218	659	9	fibres	fibre	NOUN
bam-7218	659	10	and	and	CCONJ
bam-7218	659	11	vessels	vessel	NOUN
bam-7218	659	12	,	,	PUNCT
bam-7218	659	13	and	and	CCONJ
bam-7218	659	14	induced	induce	VERB
bam-7218	659	15	larger	large	ADJ
bam-7218	659	16	crosssectional	crosssectional	ADJ
bam-7218	659	17	area	area	NOUN
bam-7218	659	18	of	of	ADP
bam-7218	659	19	type	type	NOUN
bam-7218	659	20	ii	ii	PROPN
bam-7218	659	21	fast	fast	ADJ
bam-7218	659	22	-	-	PUNCT
bam-7218	659	23	glycolytic	glycolytic	ADJ
bam-7218	659	24	fibres	fibre	NOUN
bam-7218	659	25	.	.	PUNCT
bam-7218	660	1	in	in	ADP
bam-7218	660	2	addition	addition	NOUN
bam-7218	660	3	,	,	PUNCT
bam-7218	660	4	dppsc	dppsc	NOUN
bam-7218	660	5	treatments	treatment	NOUN
bam-7218	660	6	resulted	result	VERB
bam-7218	660	7	in	in	ADP
bam-7218	660	8	reduced	reduced	ADJ
bam-7218	660	9	fibrosis	fibrosis	NOUN
bam-7218	660	10	and	and	CCONJ
bam-7218	660	11	collagen	collagen	NOUN
bam-7218	660	12	content	content	NOUN
bam-7218	660	13	and	and	CCONJ
bam-7218	660	14	changes	change	NOUN
bam-7218	660	15	in	in	ADP
bam-7218	660	16	macrophage	macrophage	ADJ
bam-7218	660	17	polarization	polarization	NOUN
bam-7218	660	18	.	.	PUNCT
bam-7218	661	1	this	this	PRON
bam-7218	661	2	is	be	AUX
bam-7218	661	3	likely	likely	ADJ
bam-7218	661	4	due	due	ADP
bam-7218	661	5	to	to	ADP
bam-7218	661	6	the	the	DET
bam-7218	661	7	observed	observe	VERB
bam-7218	661	8	cytokine	cytokine	NOUN
bam-7218	661	9	profile	profile	NOUN
bam-7218	661	10	modification	modification	NOUN
bam-7218	661	11	,	,	PUNCT
bam-7218	661	12	with	with	ADP
bam-7218	661	13	higher	high	ADJ
bam-7218	661	14	levels	level	NOUN
bam-7218	661	15	of	of	ADP
bam-7218	661	16	interleukin10	interleukin10	NOUN
bam-7218	661	17	in	in	ADP
bam-7218	661	18	dppsc	dppsc	NOUN
bam-7218	661	19	-	-	PUNCT
bam-7218	661	20	injected	inject	VERB
bam-7218	661	21	muscles	muscle	NOUN
bam-7218	661	22	compared	compare	VERB
bam-7218	661	23	to	to	ADP
bam-7218	661	24	controls	control	NOUN
bam-7218	661	25	.	.	PUNCT
bam-7218	662	1	overall	overall	ADV
bam-7218	662	2	,	,	PUNCT
bam-7218	662	3	dppsc	dppsc	NOUN
bam-7218	662	4	represent	represent	VERB
bam-7218	662	5	a	a	DET
bam-7218	662	6	source	source	NOUN
bam-7218	662	7	of	of	ADP
bam-7218	662	8	stem	stem	NOUN
bam-7218	662	9	cells	cell	NOUN
bam-7218	662	10	with	with	ADP
bam-7218	662	11	the	the	DET
bam-7218	662	12	potential	potential	NOUN
bam-7218	662	13	to	to	PART
bam-7218	662	14	enhance	enhance	VERB
bam-7218	662	15	wound	wound	ADJ
bam-7218	662	16	healing	healing	NOUN
bam-7218	662	17	and	and	CCONJ
bam-7218	662	18	slow	slow	VERB
bam-7218	662	19	down	down	ADP
bam-7218	662	20	dystrophic	dystrophic	ADJ
bam-7218	662	21	muscle	muscle	NOUN
bam-7218	662	22	degeneration	degeneration	NOUN
bam-7218	662	23	.	.	PUNCT
bam-7218	663	1	references	reference	NOUN
bam-7218	663	2	:	:	PUNCT
bam-7218	663	3	1	1	X
bam-7218	663	4	.	.	X
bam-7218	663	5	atari	atari	PROPN
bam-7218	663	6	m	m	PROPN
bam-7218	663	7	,	,	PUNCT
bam-7218	663	8	barajas	barajas	PROPN
bam-7218	663	9	m	m	PROPN
bam-7218	663	10	,	,	PUNCT
bam-7218	663	11	hernandez	hernandez	PROPN
bam-7218	663	12	-	-	PUNCT
bam-7218	663	13	alfaro	alfaro	PROPN
bam-7218	663	14	f	f	PROPN
bam-7218	663	15	,	,	PUNCT
bam-7218	663	16	gil	gil	PROPN
bam-7218	663	17	c	c	PROPN
bam-7218	663	18	,	,	PUNCT
bam-7218	663	19	fabregat	fabregat	PROPN
bam-7218	663	20	m	m	PROPN
bam-7218	663	21	,	,	PUNCT
bam-7218	663	22	ferres	ferre	VERB
bam-7218	663	23	padro	padro	PROPN
bam-7218	663	24	e	e	PROPN
bam-7218	663	25	,	,	PUNCT
bam-7218	663	26	giner	giner	NOUN
bam-7218	663	27	l	l	NOUN
bam-7218	663	28	,	,	PUNCT
bam-7218	663	29	casals	casal	NOUN
bam-7218	663	30	n	n	CCONJ
bam-7218	663	31	:	:	PUNCT
bam-7218	663	32	isolation	isolation	NOUN
bam-7218	663	33	of	of	ADP
bam-7218	663	34	pluripotent	pluripotent	ADJ
bam-7218	663	35	stem	stem	NOUN
bam-7218	663	36	cells	cell	NOUN
bam-7218	663	37	from	from	ADP
bam-7218	663	38	human	human	ADJ
bam-7218	663	39	third	third	ADJ
bam-7218	663	40	molar	molar	ADJ
bam-7218	663	41	dental	dental	ADJ
bam-7218	663	42	pulp	pulp	NOUN
bam-7218	663	43	.	.	PUNCT
bam-7218	663	44	histology	histology	NOUN
bam-7218	663	45	and	and	CCONJ
bam-7218	663	46	histopathology	histopathology	NOUN
bam-7218	663	47	2011	2011	NUM
bam-7218	663	48	,	,	PUNCT
bam-7218	663	49	26(8):10571070	26(8):10571070	NUM
bam-7218	663	50	.	.	PUNCT
bam-7218	663	51	
	
	SPACE
bam-7218	664	1	2	2	NUM
bam-7218	664	2	.	.	PUNCT
bam-7218	664	3	atari	atari	PROPN
bam-7218	664	4	m	m	PROPN
bam-7218	664	5	,	,	PUNCT
bam-7218	664	6	gil	gil	PROPN
bam-7218	664	7	-	-	PUNCT
bam-7218	664	8	recio	recio	PROPN
bam-7218	664	9	c	c	PROPN
bam-7218	664	10	,	,	PUNCT
bam-7218	664	11	fabregat	fabregat	PROPN
bam-7218	664	12	m	m	PROPN
bam-7218	664	13	,	,	PUNCT
bam-7218	664	14	garciafernandez	garciafernandez	PROPN
bam-7218	664	15	d	d	PROPN
bam-7218	664	16	,	,	PUNCT
bam-7218	664	17	barajas	barajas	PROPN
bam-7218	664	18	m	m	PROPN
bam-7218	664	19	,	,	PUNCT
bam-7218	664	20	carrasco	carrasco	PROPN
bam-7218	664	21	ma	ma	PROPN
bam-7218	664	22	,	,	PUNCT
bam-7218	664	23	jung	jung	PROPN
bam-7218	664	24	hs	hs	PROPN
bam-7218	664	25	,	,	PUNCT
bam-7218	664	26	alfaro	alfaro	PROPN
bam-7218	664	27	fh	fh	PROPN
bam-7218	664	28	,	,	PUNCT
bam-7218	664	29	casals	casal	NOUN
bam-7218	664	30	n	n	CCONJ
bam-7218	664	31	,	,	PUNCT
bam-7218	664	32	prosper	prosper	VERB
bam-7218	664	33	f	f	PROPN
bam-7218	664	34	et	et	NOUN
bam-7218	664	35	al	al	PROPN
bam-7218	664	36	:	:	PUNCT
bam-7218	664	37	dental	dental	ADJ
bam-7218	664	38	pulp	pulp	NOUN
bam-7218	664	39	of	of	ADP
bam-7218	664	40	the	the	DET
bam-7218	664	41	third	third	ADJ
bam-7218	664	42	molar	molar	NOUN
bam-7218	664	43	:	:	PUNCT
bam-7218	664	44	a	a	DET
bam-7218	664	45	new	new	ADJ
bam-7218	664	46	source	source	NOUN
bam-7218	664	47	of	of	ADP
bam-7218	664	48	pluripotent	pluripotent	NOUN
bam-7218	664	49	-	-	PUNCT
bam-7218	664	50	like	like	ADJ
bam-7218	664	51	stem	stem	NOUN
bam-7218	664	52	cells	cell	NOUN
bam-7218	664	53	.	.	PUNCT
bam-7218	665	1	journal	journal	NOUN
bam-7218	665	2	of	of	ADP
bam-7218	665	3	cell	cell	NOUN
bam-7218	665	4	science	science	NOUN
bam-7218	665	5	2012	2012	NUM
bam-7218	665	6	,	,	PUNCT
bam-7218	665	7	125(pt	125(pt	NUM
bam-7218	665	8	14):3343	14):3343	NUM
bam-7218	665	9	-	-	SYM
bam-7218	665	10	3356	3356	NUM
bam-7218	665	11	.	.	PUNCT
bam-7218	665	12	
	
	SPACE
bam-7218	666	1	3	3	NUM
bam-7218	666	2	.	.	PROPN
bam-7218	666	3	quattrocelli	quattrocelli	PROPN
bam-7218	666	4	m	m	PROPN
bam-7218	666	5	,	,	PUNCT
bam-7218	666	6	swinnen	swinnen	PROPN
bam-7218	666	7	m	m	PROPN
bam-7218	666	8	,	,	PUNCT
bam-7218	666	9	giacomazzi	giacomazzi	PROPN
bam-7218	666	10	g	g	NOUN
bam-7218	666	11	,	,	PUNCT
bam-7218	666	12	camps	camp	NOUN
bam-7218	666	13	j	j	PROPN
bam-7218	666	14	,	,	PUNCT
bam-7218	666	15	barthelemy	barthelemy	PROPN
bam-7218	666	16	i	i	PROPN
bam-7218	666	17	,	,	PUNCT
bam-7218	666	18	ceccarelli	ceccarelli	ADV
bam-7218	666	19	g	g	PROPN
bam-7218	666	20	,	,	PUNCT
bam-7218	666	21	caluwe	caluwe	NOUN
bam-7218	666	22	e	e	PROPN
bam-7218	666	23	,	,	PUNCT
bam-7218	666	24	grosemans	groseman	NOUN
bam-7218	666	25	h	h	PROPN
bam-7218	666	26	,	,	PUNCT
bam-7218	666	27	thorrez	thorrez	PROPN
bam-7218	666	28	l	l	NOUN
bam-7218	666	29	,	,	PUNCT
bam-7218	666	30	pelizzo	pelizzo	VERB
bam-7218	666	31	g	g	PROPN
bam-7218	666	32	et	et	PROPN
bam-7218	666	33	al	al	PROPN
bam-7218	666	34	:	:	PUNCT
bam-7218	666	35	mesodermal	mesodermal	ADJ
bam-7218	666	36	ipsc	ipsc	NOUN
bam-7218	666	37	-	-	PUNCT
bam-7218	666	38	derived	derive	VERB
bam-7218	666	39	progenitor	progenitor	NOUN
bam-7218	666	40	cells	cell	NOUN
bam-7218	666	41	functionally	functionally	ADV
bam-7218	666	42	regenerate	regenerate	VERB
bam-7218	666	43	cardiac	cardiac	ADJ
bam-7218	666	44	and	and	CCONJ
bam-7218	666	45	skeletal	skeletal	ADJ
bam-7218	666	46	muscle	muscle	NOUN
bam-7218	666	47	.	.	PUNCT
bam-7218	667	1	the	the	DET
bam-7218	667	2	journal	journal	NOUN
bam-7218	667	3	of	of	ADP
bam-7218	667	4	clinical	clinical	ADJ
bam-7218	667	5	investigation	investigation	NOUN
bam-7218	667	6	2015	2015	NUM
bam-7218	667	7	,	,	PUNCT
bam-7218	667	8	125(12):4463	125(12):4463	PROPN
bam-7218	667	9	-	-	SYM
bam-7218	667	10	4482	4482	NUM
bam-7218	667	11	.	.	PUNCT
bam-7218	668	1	6.5	6.5	NUM
bam-7218	668	2	strengthening	strengthen	VERB
bam-7218	668	3	the	the	DET
bam-7218	668	4	neuromuscular	neuromuscular	ADJ
bam-7218	668	5	junction	junction	NOUN
bam-7218	668	6	as	as	ADP
bam-7218	668	7	a	a	DET
bam-7218	668	8	new	new	ADJ
bam-7218	668	9	concept	concept	NOUN
bam-7218	668	10	for	for	ADP
bam-7218	668	11	the	the	DET
bam-7218	668	12	treatment	treatment	NOUN
bam-7218	668	13	of	of	ADP
bam-7218	668	14	congenital	congenital	ADJ
bam-7218	668	15	myasthenic	myasthenic	ADJ
bam-7218	668	16	syndromes	syndrome	NOUN
bam-7218	668	17	and	and	CCONJ
bam-7218	668	18	motor	motor	NOUN
bam-7218	668	19	neuropathies	neuropathy	NOUN
bam-7218	668	20	with	with	ADP
bam-7218	668	21	synaptic	synaptic	ADJ
bam-7218	668	22	dysfunction	dysfunction	NOUN
bam-7218	668	23	sally	sally	NOUN
bam-7218	668	24	spendiff	spendiff	NOUN
bam-7218	668	25	(	(	PUNCT
bam-7218	668	26	a	a	X
bam-7218	668	27	)	)	PUNCT
bam-7218	668	28	,	,	PUNCT
bam-7218	668	29	rachel	rachel	PROPN
bam-7218	668	30	howarth	howarth	PROPN
bam-7218	668	31	(	(	PUNCT
bam-7218	668	32	a	a	X
bam-7218	668	33	)	)	PUNCT
bam-7218	668	34	,	,	PUNCT
bam-7218	668	35	grace	grace	NOUN
bam-7218	668	36	mcmacken	mcmacken	VERB
bam-7218	668	37	(	(	PUNCT
bam-7218	668	38	a	a	NOUN
bam-7218	668	39	)	)	PUNCT
bam-7218	668	40	,	,	PUNCT
bam-7218	668	41	silvia	silvia	PROPN
bam-7218	668	42	cipriani	cipriani	PROPN
bam-7218	668	43	(	(	PUNCT
bam-7218	668	44	b	b	NOUN
bam-7218	668	45	)	)	PUNCT
bam-7218	668	46	,	,	PUNCT
bam-7218	668	47	andreas	andreas	PROPN
bam-7218	668	48	roos	roos	PROPN
bam-7218	668	49	(	(	PUNCT
bam-7218	668	50	a	a	X
bam-7218	668	51	)	)	PUNCT
bam-7218	668	52	,	,	PUNCT
bam-7218	668	53	rita	rita	PROPN
bam-7218	668	54	horvath	horvath	PROPN
bam-7218	668	55	(	(	PUNCT
bam-7218	668	56	a	a	DET
bam-7218	668	57	,	,	PUNCT
bam-7218	668	58	c	c	NOUN
bam-7218	668	59	)	)	PUNCT
bam-7218	668	60	,	,	PUNCT
bam-7218	668	61	hanns	hann	NOUN
bam-7218	668	62	lochmüller	lochmüll	ADJ
bam-7218	668	63	(	(	PUNCT
bam-7218	668	64	a	a	NOUN
bam-7218	668	65	)	)	PUNCT
bam-7218	668	66	(	(	PUNCT
bam-7218	668	67	a	a	X
bam-7218	668	68	)	)	PUNCT
bam-7218	668	69	john	john	PROPN
bam-7218	668	70	walton	walton	PROPN
bam-7218	668	71	muscular	muscular	ADJ
bam-7218	668	72	dystrophy	dystrophy	NOUN
bam-7218	668	73	research	research	NOUN
bam-7218	668	74	centre	centre	NOUN
bam-7218	668	75	,	,	PUNCT
bam-7218	668	76	institute	institute	NOUN
bam-7218	668	77	of	of	ADP
bam-7218	668	78	genetic	genetic	ADJ
bam-7218	668	79	medicine	medicine	NOUN
bam-7218	668	80	,	,	PUNCT
bam-7218	668	81	newcastle	newcastle	PROPN
bam-7218	668	82	university	university	PROPN
bam-7218	668	83	,	,	PUNCT
bam-7218	668	84	uk	uk	PROPN
bam-7218	668	85	;	;	PUNCT
bam-7218	668	86	(	(	PUNCT
bam-7218	668	87	b	b	X
bam-7218	668	88	)	)	PUNCT
bam-7218	668	89	università	università	PROPN
bam-7218	668	90	di	di	PROPN
bam-7218	668	91	bologna	bologna	PROPN
bam-7218	668	92	,	,	PUNCT
bam-7218	668	93	italy	italy	PROPN
bam-7218	668	94	;	;	PUNCT
bam-7218	668	95	(	(	PUNCT
bam-7218	668	96	c	c	X
bam-7218	668	97	)	)	PUNCT
bam-7218	668	98	welcome	welcome	ADJ
bam-7218	668	99	trust	trust	NOUN
bam-7218	668	100	centre	centre	NOUN
bam-7218	668	101	for	for	ADP
bam-7218	668	102	mitochondrial	mitochondrial	ADJ
bam-7218	668	103	research	research	NOUN
bam-7218	668	104	,	,	PUNCT
bam-7218	668	105	institute	institute	NOUN
bam-7218	668	106	of	of	ADP
bam-7218	668	107	neuroscience	neuroscience	NOUN
bam-7218	668	108	,	,	PUNCT
bam-7218	668	109	newcastle	newcastle	PROPN
bam-7218	668	110	university	university	PROPN
bam-7218	668	111	,	,	PUNCT
bam-7218	668	112	uk	uk	PROPN
bam-7218	668	113	.	.	PROPN
bam-7218	668	114	e	e	NOUN
bam-7218	668	115	-	-	NOUN
bam-7218	668	116	mail	mail	NOUN
bam-7218	668	117	:	:	PUNCT
bam-7218	668	118	sally.spendiff2@newcastle.ac.uk	sally.spendiff2@newcastle.ac.uk	VERB
bam-7218	668	119	disruption	disruption	NOUN
bam-7218	668	120	of	of	ADP
bam-7218	668	121	the	the	DET
bam-7218	668	122	development	development	NOUN
bam-7218	668	123	and	and	CCONJ
bam-7218	668	124	maintenance	maintenance	NOUN
bam-7218	668	125	of	of	ADP
bam-7218	668	126	the	the	DET
bam-7218	668	127	neuromuscular	neuromuscular	ADJ
bam-7218	668	128	junction	junction	NOUN
bam-7218	668	129	(	(	PUNCT
bam-7218	668	130	nmj	nmj	NOUN
bam-7218	668	131	)	)	PUNCT
bam-7218	668	132	through	through	ADP
bam-7218	668	133	mutations	mutation	NOUN
bam-7218	668	134	in	in	ADP
bam-7218	668	135	the	the	DET
bam-7218	668	136	genes	gene	NOUN
bam-7218	668	137	encoding	encode	VERB
bam-7218	668	138	its	its	PRON
bam-7218	668	139	components	component	NOUN
bam-7218	668	140	lead	lead	VERB
bam-7218	668	141	to	to	ADP
bam-7218	668	142	congenital	congenital	ADJ
bam-7218	668	143	myasthenic	myasthenic	ADJ
bam-7218	668	144	syndromes	syndrome	NOUN
bam-7218	668	145	(	(	PUNCT
bam-7218	668	146	cms	cms	NOUN
bam-7218	668	147	)	)	PUNCT
bam-7218	668	148	.	.	PUNCT
bam-7218	669	1	these	these	DET
bam-7218	669	2	disorders	disorder	NOUN
bam-7218	669	3	result	result	VERB
bam-7218	669	4	in	in	ADP
bam-7218	669	5	impaired	impaired	ADJ
bam-7218	669	6	neurotransmission	neurotransmission	NOUN
bam-7218	669	7	and	and	CCONJ
bam-7218	669	8	muscle	muscle	NOUN
bam-7218	669	9	weakness	weakness	NOUN
bam-7218	669	10	;	;	PUNCT
bam-7218	669	11	current	current	ADJ
bam-7218	669	12	treatments	treatment	NOUN
bam-7218	669	13	for	for	ADP
bam-7218	669	14	these	these	DET
bam-7218	669	15	conditions	condition	NOUN
bam-7218	669	16	are	be	AUX
bam-7218	669	17	limited	limit	VERB
bam-7218	669	18	.	.	PUNCT
bam-7218	670	1	development	development	NOUN
bam-7218	670	2	and	and	CCONJ
bam-7218	670	3	maintenance	maintenance	NOUN
bam-7218	670	4	of	of	ADP
bam-7218	670	5	the	the	DET
bam-7218	670	6	nmj	nmj	NOUN
bam-7218	670	7	depends	depend	VERB
bam-7218	670	8	on	on	ADP
bam-7218	670	9	the	the	DET
bam-7218	670	10	neuronal	neuronal	ADJ
bam-7218	670	11	factor	factor	NOUN
bam-7218	670	12	agrin	agrin	NOUN
bam-7218	670	13	and	and	CCONJ
bam-7218	670	14	its	its	PRON
bam-7218	670	15	downstream	downstream	ADJ
bam-7218	670	16	pathway	pathway	NOUN
bam-7218	670	17	.	.	PUNCT
bam-7218	671	1	neurotune	neurotune	PROPN
bam-7218	671	2	ag	ag	PROPN
bam-7218	671	3	has	have	AUX
bam-7218	671	4	developed	develop	VERB
bam-7218	671	5	a	a	DET
bam-7218	671	6	modified	modify	VERB
bam-7218	671	7	form	form	NOUN
bam-7218	671	8	of	of	ADP
bam-7218	671	9	agrin	agrin	NOUN
bam-7218	671	10	(	(	PUNCT
bam-7218	671	11	nt-1654	nt-1654	PROPN
bam-7218	671	12	)	)	PUNCT
bam-7218	671	13	which	which	PRON
bam-7218	671	14	has	have	AUX
bam-7218	671	15	been	be	AUX
bam-7218	671	16	show	show	NOUN
bam-7218	671	17	to	to	PART
bam-7218	671	18	stimulate	stimulate	VERB
bam-7218	671	19	the	the	DET
bam-7218	671	20	nmj	nmj	PROPN
bam-7218	671	21	development	development	NOUN
bam-7218	671	22	pathway	pathway	NOUN
bam-7218	671	23	.	.	PUNCT
bam-7218	672	1	the	the	DET
bam-7218	672	2	aim	aim	NOUN
bam-7218	672	3	of	of	ADP
bam-7218	672	4	this	this	DET
bam-7218	672	5	project	project	NOUN
bam-7218	672	6	is	be	AUX
bam-7218	672	7	to	to	PART
bam-7218	672	8	test	test	VERB
bam-7218	672	9	nt-1654	nt-1654	PROPN
bam-7218	672	10	in	in	ADP
bam-7218	672	11	mouse	mouse	NOUN
bam-7218	672	12	models	model	NOUN
bam-7218	672	13	of	of	ADP
bam-7218	672	14	human	human	ADJ
bam-7218	672	15	cms	cms	PROPN
bam-7218	672	16	,	,	PUNCT
bam-7218	672	17	and	and	CCONJ
bam-7218	672	18	provide	provide	VERB
bam-7218	672	19	evidence	evidence	NOUN
bam-7218	672	20	for	for	ADP
bam-7218	672	21	its	its	PRON
bam-7218	672	22	use	use	NOUN
bam-7218	672	23	as	as	ADP
bam-7218	672	24	a	a	DET
bam-7218	672	25	therapeutic	therapeutic	ADJ
bam-7218	672	26	compound	compound	NOUN
bam-7218	672	27	in	in	ADP
bam-7218	672	28	humans	human	NOUN
bam-7218	672	29	.	.	PUNCT
bam-7218	673	1	we	we	PRON
bam-7218	673	2	have	have	AUX
bam-7218	673	3	conducted	conduct	VERB
bam-7218	673	4	dose	dose	NOUN
bam-7218	673	5	finding	find	VERB
bam-7218	673	6	studies	study	NOUN
bam-7218	673	7	to	to	PART
bam-7218	673	8	identify	identify	VERB
bam-7218	673	9	safe	safe	ADJ
bam-7218	673	10	,	,	PUNCT
bam-7218	673	11	non	non	ADJ
bam-7218	673	12	-	-	ADJ
bam-7218	673	13	toxic	toxic	ADJ
bam-7218	673	14	concentrations	concentration	NOUN
bam-7218	673	15	of	of	ADP
bam-7218	673	16	the	the	DET
bam-7218	673	17	drug	drug	NOUN
bam-7218	673	18	in	in	ADP
bam-7218	673	19	three	three	NUM
bam-7218	673	20	animal	animal	NOUN
bam-7218	673	21	models	model	NOUN
bam-7218	673	22	of	of	ADP
bam-7218	673	23	cms	cms	NOUN
bam-7218	673	24	:	:	PUNCT
bam-7218	673	25	dok7(c.1124_1127duptgcc	dok7(c.1124_1127duptgcc	NOUN
bam-7218	673	26	)	)	PUNCT
bam-7218	673	27	,	,	PUNCT
bam-7218	673	28	colq(-/-	colq(-/-	NOUN
bam-7218	673	29	)	)	PUNCT
bam-7218	673	30	,	,	PUNCT
bam-7218	673	31	and	and	CCONJ
bam-7218	673	32	agrin	agrin	NOUN
bam-7218	673	33	(	(	PUNCT
bam-7218	673	34	nmf380	nmf380	PROPN
bam-7218	673	35	)	)	PUNCT
bam-7218	673	36	,	,	PUNCT
bam-7218	673	37	and	and	CCONJ
bam-7218	673	38	one	one	NUM
bam-7218	673	39	of	of	ADP
bam-7218	673	40	hereditary	hereditary	ADJ
bam-7218	673	41	neuropathy	neuropathy	ADJ
bam-7218	673	42	:	:	PUNCT
bam-7218	673	43	mailto:ester.martinezsarra@kuleuven.be	mailto:ester.martinezsarra@kuleuven.be	PROPN
bam-7218	673	44	mailto:sally.spendiff2@newcastle.ac.uk	mailto:sally.spendiff2@newcastle.ac.uk	NOUN
bam-7218	673	45	14	14	NUM
bam-7218	673	46	th	th	NUM
bam-7218	673	47	iiim	iiim	NOUN
bam-7218	673	48	meeting	meeting	NOUN
bam-7218	673	49	,	,	PUNCT
bam-7218	673	50	assisi	assisi	PROPN
bam-7218	673	51	,	,	PUNCT
bam-7218	673	52	italy	italy	PROPN
bam-7218	673	53	october	october	PROPN
bam-7218	673	54	12	12	NUM
bam-7218	673	55	-	-	SYM
bam-7218	673	56	15	15	NUM
bam-7218	673	57	2017	2017	NUM
bam-7218	673	58	eur	eur	PROPN
bam-7218	673	59	j	j	PROPN
bam-7218	673	60	transl	transl	PROPN
bam-7218	673	61	myol	myol	ADV
bam-7218	673	62	27	27	NUM
bam-7218	673	63	(	(	PUNCT
bam-7218	673	64	4	4	NUM
bam-7218	673	65	):	):	SYM
bam-7218	673	66	185	185	NUM
bam-7218	673	67	-	-	SYM
bam-7218	673	68	224	224	NUM
bam-7218	673	69	205	205	NUM
bam-7218	673	70	gars(c201r	gars(c201r	NOUN
bam-7218	673	71	)	)	PUNCT
bam-7218	673	72	.	.	PUNCT
bam-7218	674	1	daily	daily	ADJ
bam-7218	674	2	subcutaneous	subcutaneous	ADJ
bam-7218	674	3	injections	injection	NOUN
bam-7218	674	4	of	of	ADP
bam-7218	674	5	either	either	PRON
bam-7218	674	6	1mg	1mg	PROPN
bam-7218	674	7	/	/	SYM
bam-7218	674	8	kg	kg	PROPN
bam-7218	674	9	,	,	PUNCT
bam-7218	674	10	5mg	5mg	ADJ
bam-7218	674	11	/	/	SYM
bam-7218	674	12	kg	kg	PROPN
bam-7218	674	13	,	,	PUNCT
bam-7218	674	14	10mg	10mg	NOUN
bam-7218	674	15	/	/	SYM
bam-7218	674	16	kg	kg	PROPN
bam-7218	674	17	,	,	PUNCT
bam-7218	674	18	or	or	CCONJ
bam-7218	674	19	pbs	pbs	PROPN
bam-7218	674	20	,	,	PUNCT
bam-7218	674	21	were	be	AUX
bam-7218	674	22	administered	administer	VERB
bam-7218	674	23	and	and	CCONJ
bam-7218	674	24	animals	animal	NOUN
bam-7218	674	25	monitored	monitor	VERB
bam-7218	674	26	for	for	ADP
bam-7218	674	27	signs	sign	NOUN
bam-7218	674	28	of	of	ADP
bam-7218	674	29	adverse	adverse	ADJ
bam-7218	674	30	reactions	reaction	NOUN
bam-7218	674	31	and	and	CCONJ
bam-7218	674	32	toxic	toxic	ADJ
bam-7218	674	33	effects	effect	NOUN
bam-7218	674	34	.	.	PUNCT
bam-7218	675	1	so	so	ADV
bam-7218	675	2	far	far	ADV
bam-7218	675	3	all	all	DET
bam-7218	675	4	animals	animal	NOUN
bam-7218	675	5	have	have	AUX
bam-7218	675	6	all	all	PRON
bam-7218	675	7	tolerated	tolerate	VERB
bam-7218	675	8	the	the	DET
bam-7218	675	9	drug	drug	NOUN
bam-7218	675	10	well	well	ADV
bam-7218	675	11	,	,	PUNCT
bam-7218	675	12	with	with	ADP
bam-7218	675	13	no	no	DET
bam-7218	675	14	adverse	adverse	ADJ
bam-7218	675	15	changes	change	NOUN
bam-7218	675	16	being	be	AUX
bam-7218	675	17	noticed	notice	VERB
bam-7218	675	18	.	.	PUNCT
bam-7218	676	1	full	full	ADJ
bam-7218	676	2	studies	study	NOUN
bam-7218	676	3	administering	administer	VERB
bam-7218	676	4	nt1654	nt1654	PROPN
bam-7218	676	5	have	have	AUX
bam-7218	676	6	now	now	ADV
bam-7218	676	7	been	be	AUX
bam-7218	676	8	initiated	initiate	VERB
bam-7218	676	9	in	in	ADP
bam-7218	676	10	two	two	NUM
bam-7218	676	11	of	of	ADP
bam-7218	676	12	the	the	DET
bam-7218	676	13	cms	cms	NOUN
bam-7218	676	14	models	model	NOUN
bam-7218	676	15	with	with	ADP
bam-7218	676	16	further	further	ADJ
bam-7218	676	17	models	model	NOUN
bam-7218	676	18	expected	expect	VERB
bam-7218	676	19	to	to	PART
bam-7218	676	20	begin	begin	VERB
bam-7218	676	21	soon	soon	ADV
bam-7218	676	22	.	.	PUNCT
bam-7218	677	1	preliminary	preliminary	ADJ
bam-7218	677	2	data	datum	NOUN
bam-7218	677	3	regarding	regard	VERB
bam-7218	677	4	body	body	NOUN
bam-7218	677	5	weight	weight	NOUN
bam-7218	677	6	,	,	PUNCT
bam-7218	677	7	grip	grip	NOUN
bam-7218	677	8	strength	strength	NOUN
bam-7218	677	9	,	,	PUNCT
bam-7218	677	10	swallowing	swallow	VERB
bam-7218	677	11	ability	ability	NOUN
bam-7218	677	12	,	,	PUNCT
bam-7218	677	13	and	and	CCONJ
bam-7218	677	14	survival	survival	NOUN
bam-7218	677	15	will	will	AUX
bam-7218	677	16	be	be	AUX
bam-7218	677	17	presented	present	VERB
bam-7218	677	18	.	.	PUNCT
bam-7218	678	1	it	it	PRON
bam-7218	678	2	is	be	AUX
bam-7218	678	3	hoped	hope	VERB
bam-7218	678	4	that	that	SCONJ
bam-7218	678	5	these	these	DET
bam-7218	678	6	investigations	investigation	NOUN
bam-7218	678	7	will	will	AUX
bam-7218	678	8	provide	provide	VERB
bam-7218	678	9	the	the	DET
bam-7218	678	10	rationale	rationale	NOUN
bam-7218	678	11	for	for	ADP
bam-7218	678	12	beginning	begin	VERB
bam-7218	678	13	human	human	ADJ
bam-7218	678	14	trials	trial	NOUN
bam-7218	678	15	of	of	ADP
bam-7218	678	16	nt1654	nt1654	PROPN
bam-7218	678	17	in	in	ADP
bam-7218	678	18	patients	patient	NOUN
bam-7218	678	19	.	.	PUNCT
bam-7218	679	1	6.6	6.6	NUM
bam-7218	679	2	autologous	autologous	ADJ
bam-7218	679	3	intramuscular	intramuscular	ADJ
bam-7218	679	4	transplantation	transplantation	NOUN
bam-7218	679	5	of	of	ADP
bam-7218	679	6	engineered	engineer	VERB
bam-7218	679	7	satellite	satellite	NOUN
bam-7218	679	8	cells	cell	NOUN
bam-7218	679	9	induces	induce	VERB
bam-7218	679	10	exosome	exosome	ADV
bam-7218	679	11	-	-	PUNCT
bam-7218	679	12	mediated	mediate	VERB
bam-7218	679	13	systemic	systemic	ADJ
bam-7218	679	14	expression	expression	NOUN
bam-7218	679	15	of	of	ADP
bam-7218	679	16	fukutin	fukutin	NOUN
bam-7218	679	17	-	-	PUNCT
bam-7218	679	18	related	relate	VERB
bam-7218	679	19	protein	protein	NOUN
bam-7218	679	20	and	and	CCONJ
bam-7218	679	21	rescues	rescue	NOUN
bam-7218	679	22	disease	disease	NOUN
bam-7218	679	23	phenotype	phenotype	NOUN
bam-7218	679	24	in	in	ADP
bam-7218	679	25	a	a	DET
bam-7218	679	26	murine	murine	ADJ
bam-7218	679	27	model	model	NOUN
bam-7218	679	28	of	of	ADP
bam-7218	679	29	limb	limb	NOUN
bam-7218	679	30	-	-	PUNCT
bam-7218	679	31	girdle	girdle	NOUN
bam-7218	679	32	muscular	muscular	ADJ
bam-7218	679	33	dystrophy	dystrophy	NOUN
bam-7218	679	34	type	type	NOUN
bam-7218	679	35	2i	2i	PROPN
bam-7218	679	36	paola	paola	PROPN
bam-7218	679	37	frattini	frattini	ADV
bam-7218	679	38	(	(	PUNCT
bam-7218	679	39	a	a	NOUN
bam-7218	679	40	)	)	PUNCT
bam-7218	679	41	,	,	PUNCT
bam-7218	679	42	chiara	chiara	PROPN
bam-7218	679	43	villa	villa	PROPN
bam-7218	679	44	(	(	PUNCT
bam-7218	679	45	a	a	NOUN
bam-7218	679	46	)	)	PUNCT
bam-7218	679	47	,	,	PUNCT
bam-7218	679	48	francesca	francesca	PROPN
bam-7218	679	49	de	de	PROPN
bam-7218	679	50	santis	santis	PROPN
bam-7218	679	51	(	(	PUNCT
bam-7218	679	52	a	a	NOUN
bam-7218	679	53	)	)	PUNCT
bam-7218	679	54	,	,	PUNCT
bam-7218	679	55	mirella	mirella	PROPN
bam-7218	679	56	meregalli	meregalli	PROPN
bam-7218	679	57	(	(	PUNCT
bam-7218	679	58	a	a	DET
bam-7218	679	59	,	,	PUNCT
bam-7218	679	60	b	b	NOUN
bam-7218	679	61	)	)	PUNCT
bam-7218	679	62	,	,	PUNCT
bam-7218	679	63	marzia	marzia	PROPN
bam-7218	679	64	belicchi	belicchi	PROPN
bam-7218	679	65	(	(	PUNCT
bam-7218	679	66	a	a	DET
bam-7218	679	67	,	,	PUNCT
bam-7218	679	68	b	b	NOUN
bam-7218	679	69	)	)	PUNCT
bam-7218	679	70	,	,	PUNCT
bam-7218	679	71	silvia	silvia	PROPN
bam-7218	679	72	erratico	erratico	NOUN
bam-7218	679	73	(	(	PUNCT
bam-7218	679	74	b	b	NOUN
bam-7218	679	75	)	)	PUNCT
bam-7218	679	76	,	,	PUNCT
bam-7218	679	77	pamela	pamela	PROPN
bam-7218	679	78	bella	bella	PROPN
bam-7218	679	79	(	(	PUNCT
bam-7218	679	80	a	a	NOUN
bam-7218	679	81	)	)	PUNCT
bam-7218	679	82	,	,	PUNCT
bam-7218	679	83	manuela	manuela	PROPN
bam-7218	679	84	teresa	teresa	PROPN
bam-7218	679	85	raimondi	raimondi	PROPN
bam-7218	679	86	(	(	PUNCT
bam-7218	679	87	d	d	NOUN
bam-7218	679	88	)	)	PUNCT
bam-7218	679	89	,	,	PUNCT
bam-7218	679	90	qilong	qilong	ADJ
bam-7218	679	91	lu	lu	PROPN
bam-7218	679	92	(	(	PUNCT
bam-7218	679	93	e	e	NOUN
bam-7218	679	94	)	)	PUNCT
bam-7218	679	95	,	,	PUNCT
bam-7218	679	96	yvan	yvan	PROPN
bam-7218	679	97	torrente	torrente	PROPN
bam-7218	679	98	(	(	PUNCT
bam-7218	679	99	a	a	DET
bam-7218	679	100	,	,	PUNCT
bam-7218	679	101	b	b	NOUN
bam-7218	679	102	,	,	PUNCT
bam-7218	679	103	c	c	NOUN
bam-7218	679	104	)	)	PUNCT
bam-7218	679	105	(	(	PUNCT
bam-7218	679	106	a	a	X
bam-7218	679	107	)	)	PUNCT
bam-7218	679	108	stem	stem	NOUN
bam-7218	679	109	cell	cell	NOUN
bam-7218	679	110	laboratory	laboratory	NOUN
bam-7218	679	111	,	,	PUNCT
bam-7218	679	112	dept	dept	NOUN
bam-7218	679	113	of	of	ADP
bam-7218	679	114	pathophysiology	pathophysiology	NOUN
bam-7218	679	115	and	and	CCONJ
bam-7218	679	116	transplantation	transplantation	NOUN
bam-7218	679	117	,	,	PUNCT
bam-7218	679	118	università	università	PROPN
bam-7218	679	119	degli	degli	PROPN
bam-7218	679	120	studi	studi	PROPN
bam-7218	679	121	di	di	X
bam-7218	679	122	milano	milano	PROPN
bam-7218	679	123	,	,	PUNCT
bam-7218	679	124	unit	unit	NOUN
bam-7218	679	125	of	of	ADP
bam-7218	679	126	neurology	neurology	NOUN
bam-7218	679	127	,	,	PUNCT
bam-7218	679	128	fondazione	fondazione	NOUN
bam-7218	679	129	irccs	irccs	NOUN
bam-7218	679	130	ca	ca	NOUN
bam-7218	679	131	'	'	PART
bam-7218	679	132	granda	granda	PROPN
bam-7218	679	133	ospedale	ospedale	PROPN
bam-7218	679	134	maggiore	maggiore	PROPN
bam-7218	679	135	policlinico	policlinico	NOUN
bam-7218	679	136	,	,	PUNCT
bam-7218	679	137	centro	centro	PROPN
bam-7218	679	138	dino	dino	PROPN
bam-7218	679	139	ferrari	ferrari	PROPN
bam-7218	679	140	,	,	PUNCT
bam-7218	679	141	milan	milan	PROPN
bam-7218	679	142	,	,	PUNCT
bam-7218	679	143	italy	italy	PROPN
bam-7218	679	144	;	;	PUNCT
bam-7218	679	145	(	(	PUNCT
bam-7218	679	146	b	b	X
bam-7218	679	147	)	)	PUNCT
bam-7218	679	148	novastem	novastem	PROPN
bam-7218	679	149	srl	srl	PROPN
bam-7218	679	150	,	,	PUNCT
bam-7218	679	151	milan	milan	PROPN
bam-7218	679	152	,	,	PUNCT
bam-7218	679	153	italy	italy	PROPN
bam-7218	679	154	;	;	PUNCT
bam-7218	679	155	(	(	PUNCT
bam-7218	679	156	c	c	X
bam-7218	679	157	)	)	PUNCT
bam-7218	679	158	ystem	ystem	NOUN
bam-7218	679	159	s.r.l	s.r.l	NOUN
bam-7218	679	160	.	.	PROPN
bam-7218	679	161	,	,	PUNCT
bam-7218	679	162	milan	milan	PROPN
bam-7218	679	163	,	,	PUNCT
bam-7218	679	164	italy	italy	PROPN
bam-7218	679	165	;	;	PUNCT
bam-7218	679	166	(	(	PUNCT
bam-7218	679	167	d	d	X
bam-7218	679	168	)	)	PUNCT
bam-7218	679	169	dept	dept	NOUN
bam-7218	679	170	of	of	ADP
bam-7218	679	171	chemistry	chemistry	NOUN
bam-7218	679	172	,	,	PUNCT
bam-7218	679	173	materials	material	NOUN
bam-7218	679	174	and	and	CCONJ
bam-7218	679	175	chemical	chemical	NOUN
bam-7218	679	176	engineering	engineering	NOUN
bam-7218	679	177	“	"	PUNCT
bam-7218	679	178	giulio	giulio	PROPN
bam-7218	679	179	natta	natta	PROPN
bam-7218	679	180	”	"	PUNCT
bam-7218	679	181	,	,	PUNCT
bam-7218	679	182	politecnico	politecnico	PROPN
bam-7218	679	183	di	di	PROPN
bam-7218	679	184	milano	milano	PROPN
bam-7218	679	185	,	,	PUNCT
bam-7218	679	186	milan	milan	PROPN
bam-7218	679	187	,	,	PUNCT
bam-7218	679	188	italy	italy	PROPN
bam-7218	679	189	;	;	PUNCT
bam-7218	679	190	(	(	PUNCT
bam-7218	679	191	e	e	X
bam-7218	679	192	)	)	PUNCT
bam-7218	679	193	mccoll	mccoll	PROPN
bam-7218	679	194	-	-	PUNCT
bam-7218	679	195	lockwood	lockwood	PROPN
bam-7218	679	196	laboratory	laboratory	NOUN
bam-7218	679	197	for	for	ADP
bam-7218	679	198	muscular	muscular	ADJ
bam-7218	679	199	dystrophy	dystrophy	NOUN
bam-7218	679	200	research	research	NOUN
bam-7218	679	201	,	,	PUNCT
bam-7218	679	202	neuromuscular	neuromuscular	ADJ
bam-7218	679	203	/	/	SYM
bam-7218	679	204	als	als	NOUN
bam-7218	679	205	center	center	NOUN
bam-7218	679	206	,	,	PUNCT
bam-7218	679	207	dept	dept	NOUN
bam-7218	679	208	of	of	ADP
bam-7218	679	209	neurology	neurology	NOUN
bam-7218	679	210	,	,	PUNCT
bam-7218	679	211	carolinas	carolinas	PROPN
bam-7218	679	212	medical	medical	PROPN
bam-7218	679	213	center	center	PROPN
bam-7218	679	214	,	,	PUNCT
bam-7218	679	215	charlotte	charlotte	PROPN
bam-7218	679	216	,	,	PUNCT
bam-7218	679	217	north	north	PROPN
bam-7218	679	218	carolina	carolina	PROPN
bam-7218	679	219	,	,	PUNCT
bam-7218	679	220	united	united	PROPN
bam-7218	679	221	states	states	PROPN
bam-7218	679	222	of	of	ADP
bam-7218	679	223	america	america	PROPN
bam-7218	679	224	.	.	PUNCT
bam-7218	680	1	e	e	X
bam-7218	680	2	-	-	NOUN
bam-7218	680	3	mail	mail	NOUN
bam-7218	680	4	:	:	PUNCT
bam-7218	680	5	yvan.torrente@unimi.it	yvan.torrente@unimi.it	NOUN
bam-7218	680	6	α	α	NOUN
bam-7218	680	7	-	-	PUNCT
bam-7218	680	8	dystroglycanopathies	dystroglycanopathie	NOUN
bam-7218	680	9	are	be	AUX
bam-7218	680	10	a	a	DET
bam-7218	680	11	group	group	NOUN
bam-7218	680	12	of	of	ADP
bam-7218	680	13	muscular	muscular	ADJ
bam-7218	680	14	dystrophies	dystrophy	NOUN
bam-7218	680	15	characterized	characterize	VERB
bam-7218	680	16	by	by	ADP
bam-7218	680	17	α	α	PROPN
bam-7218	680	18	-	-	PUNCT
bam-7218	680	19	dg	dg	NOUN
bam-7218	680	20	hypoglycosylation	hypoglycosylation	NOUN
bam-7218	680	21	and	and	CCONJ
bam-7218	680	22	reduced	reduce	VERB
bam-7218	680	23	extracellular	extracellular	ADJ
bam-7218	680	24	ligand	ligand	NOUN
bam-7218	680	25	-	-	PUNCT
bam-7218	680	26	binding	bind	VERB
bam-7218	680	27	affinity	affinity	NOUN
bam-7218	680	28	.	.	PUNCT
bam-7218	681	1	among	among	ADP
bam-7218	681	2	other	other	ADJ
bam-7218	681	3	genes	gene	NOUN
bam-7218	681	4	involved	involve	VERB
bam-7218	681	5	in	in	ADP
bam-7218	681	6	the	the	DET
bam-7218	681	7	α	α	NOUN
bam-7218	681	8	-	-	PUNCT
bam-7218	681	9	dg	dg	NOUN
bam-7218	681	10	glycosylation	glycosylation	NOUN
bam-7218	681	11	process	process	NOUN
bam-7218	681	12	,	,	PUNCT
bam-7218	681	13	fukutin	fukutin	NOUN
bam-7218	681	14	related	relate	VERB
bam-7218	681	15	protein	protein	NOUN
bam-7218	681	16	(	(	PUNCT
bam-7218	681	17	fkrp	fkrp	NOUN
bam-7218	681	18	)	)	PUNCT
bam-7218	681	19	gene	gene	NOUN
bam-7218	681	20	mutations	mutation	NOUN
bam-7218	681	21	generate	generate	VERB
bam-7218	681	22	a	a	DET
bam-7218	681	23	wide	wide	ADJ
bam-7218	681	24	range	range	NOUN
bam-7218	681	25	of	of	ADP
bam-7218	681	26	pathologies	pathology	NOUN
bam-7218	681	27	from	from	ADP
bam-7218	681	28	mild	mild	ADJ
bam-7218	681	29	limb	limb	NOUN
bam-7218	681	30	girdle	girdle	NOUN
bam-7218	681	31	muscular	muscular	ADJ
bam-7218	681	32	dystrophy	dystrophy	NOUN
bam-7218	681	33	2i	2i	NOUN
bam-7218	681	34	(	(	PUNCT
bam-7218	681	35	lgmd2i	lgmd2i	PROPN
bam-7218	681	36	)	)	PUNCT
bam-7218	681	37	,	,	PUNCT
bam-7218	681	38	severe	severe	ADJ
bam-7218	681	39	congenital	congenital	ADJ
bam-7218	681	40	muscular	muscular	ADJ
bam-7218	681	41	dystrophy	dystrophy	NOUN
bam-7218	681	42	1c	1c	NOUN
bam-7218	681	43	(	(	PUNCT
bam-7218	681	44	mdc1c	mdc1c	NOUN
bam-7218	681	45	)	)	PUNCT
bam-7218	681	46	,	,	PUNCT
bam-7218	681	47	to	to	ADP
bam-7218	681	48	walker	walker	NOUN
bam-7218	681	49	-	-	PUNCT
bam-7218	681	50	warburg	warburg	PROPN
bam-7218	681	51	syndrome	syndrome	NOUN
bam-7218	681	52	and	and	CCONJ
bam-7218	681	53	muscle	muscle	NOUN
bam-7218	681	54	-	-	PUNCT
bam-7218	681	55	eye	eye	NOUN
bam-7218	681	56	-	-	PUNCT
bam-7218	681	57	brain	brain	NOUN
bam-7218	681	58	disease	disease	NOUN
bam-7218	681	59	.	.	PUNCT
bam-7218	682	1	fkrp	fkrp	NOUN
bam-7218	682	2	gene	gene	NOUN
bam-7218	682	3	encodes	encode	NOUN
bam-7218	682	4	for	for	ADP
bam-7218	682	5	a	a	DET
bam-7218	682	6	glycosyltransferase	glycosyltransferase	NOUN
bam-7218	682	7	that	that	SCONJ
bam-7218	682	8	in	in	ADP
bam-7218	682	9	vivo	vivo	NOUN
bam-7218	682	10	transfers	transfer	NOUN
bam-7218	682	11	a	a	DET
bam-7218	682	12	ribitol	ribitol	ADJ
bam-7218	682	13	phosphate	phosphate	NOUN
bam-7218	682	14	group	group	NOUN
bam-7218	682	15	from	from	ADP
bam-7218	682	16	a	a	DET
bam-7218	682	17	cdp	cdp	NOUN
bam-7218	682	18	–	–	PUNCT
bam-7218	682	19	ribitol	ribitol	ADJ
bam-7218	682	20	present	present	NOUN
bam-7218	682	21	in	in	ADP
bam-7218	682	22	muscles	muscle	NOUN
bam-7218	682	23	to	to	ADP
bam-7218	682	24	α	α	NOUN
bam-7218	682	25	-	-	PUNCT
bam-7218	682	26	dg	dg	NOUN
bam-7218	682	27	,	,	PUNCT
bam-7218	682	28	while	while	SCONJ
bam-7218	682	29	in	in	ADP
bam-7218	682	30	vitro	vitro	X
bam-7218	682	31	it	it	PRON
bam-7218	682	32	can	can	AUX
bam-7218	682	33	be	be	AUX
bam-7218	682	34	secreted	secrete	VERB
bam-7218	682	35	as	as	ADP
bam-7218	682	36	monomer	monomer	NOUN
bam-7218	682	37	of	of	ADP
bam-7218	682	38	60kda	60kda	NOUN
bam-7218	682	39	.	.	PUNCT
bam-7218	683	1	consistently	consistently	ADV
bam-7218	683	2	,	,	PUNCT
bam-7218	683	3	new	new	ADJ
bam-7218	683	4	evidences	evidence	NOUN
bam-7218	683	5	reported	report	VERB
bam-7218	683	6	glycosyltransferases	glycosyltransferase	NOUN
bam-7218	683	7	in	in	ADP
bam-7218	683	8	the	the	DET
bam-7218	683	9	blood	blood	NOUN
bam-7218	683	10	,	,	PUNCT
bam-7218	683	11	freely	freely	ADV
bam-7218	683	12	circulating	circulate	VERB
bam-7218	683	13	or	or	CCONJ
bam-7218	683	14	wrapped	wrap	VERB
bam-7218	683	15	within	within	ADP
bam-7218	683	16	vesicles	vesicle	NOUN
bam-7218	683	17	.	.	PUNCT
bam-7218	684	1	although	although	SCONJ
bam-7218	684	2	the	the	DET
bam-7218	684	3	physiological	physiological	ADJ
bam-7218	684	4	function	function	NOUN
bam-7218	684	5	of	of	ADP
bam-7218	684	6	blood	blood	NOUN
bam-7218	684	7	stream	stream	NOUN
bam-7218	684	8	glycosyltransferases	glycosyltransferase	NOUN
bam-7218	684	9	remains	remain	VERB
bam-7218	684	10	unclear	unclear	ADJ
bam-7218	684	11	,	,	PUNCT
bam-7218	684	12	they	they	PRON
bam-7218	684	13	are	be	AUX
bam-7218	684	14	likely	likely	ADV
bam-7218	684	15	released	release	VERB
bam-7218	684	16	from	from	ADP
bam-7218	684	17	blood	blood	NOUN
bam-7218	684	18	borne	borne	NOUN
bam-7218	684	19	or	or	CCONJ
bam-7218	684	20	distant	distant	ADJ
bam-7218	684	21	cells	cell	NOUN
bam-7218	684	22	.	.	PUNCT
bam-7218	685	1	thus	thus	ADV
bam-7218	685	2	,	,	PUNCT
bam-7218	685	3	we	we	PRON
bam-7218	685	4	hypothesized	hypothesize	VERB
bam-7218	685	5	that	that	SCONJ
bam-7218	685	6	freely	freely	ADV
bam-7218	685	7	or	or	CCONJ
bam-7218	685	8	wrapped	wrap	VERB
bam-7218	685	9	fkrp	fkrp	NOUN
bam-7218	685	10	might	might	AUX
bam-7218	685	11	circulate	circulate	VERB
bam-7218	685	12	as	as	ADP
bam-7218	685	13	an	an	DET
bam-7218	685	14	extracellular	extracellular	ADJ
bam-7218	685	15	glycosyltransferase	glycosyltransferase	NOUN
bam-7218	685	16	,	,	PUNCT
bam-7218	685	17	able	able	ADJ
bam-7218	685	18	to	to	PART
bam-7218	685	19	exert	exert	VERB
bam-7218	685	20	a	a	DET
bam-7218	685	21	“	"	PUNCT
bam-7218	685	22	glycan	glycan	NOUN
bam-7218	685	23	remodelling	remodelling	NOUN
bam-7218	685	24	”	"	PUNCT
bam-7218	685	25	process	process	NOUN
bam-7218	685	26	,	,	PUNCT
bam-7218	685	27	even	even	ADV
bam-7218	685	28	at	at	ADP
bam-7218	685	29	distal	distal	ADJ
bam-7218	685	30	compartments	compartment	NOUN
bam-7218	685	31	.	.	PUNCT
bam-7218	686	1	interestingly	interestingly	ADV
bam-7218	686	2	,	,	PUNCT
bam-7218	686	3	we	we	PRON
bam-7218	686	4	firstly	firstly	ADV
bam-7218	686	5	demonstrated	demonstrate	VERB
bam-7218	686	6	a	a	DET
bam-7218	686	7	successful	successful	ADJ
bam-7218	686	8	transduction	transduction	NOUN
bam-7218	686	9	of	of	ADP
bam-7218	686	10	mdc1c	mdc1c	PROPN
bam-7218	686	11	blood	blood	NOUN
bam-7218	686	12	-	-	PUNCT
bam-7218	686	13	derived	derive	VERB
bam-7218	686	14	cd133	cd133	NOUN
bam-7218	686	15	+	+	CCONJ
bam-7218	686	16	cells	cell	NOUN
bam-7218	686	17	and	and	CCONJ
bam-7218	686	18	fkrp	fkrp	NOUN
bam-7218	686	19	l276iki	l276iki	PROPN
bam-7218	686	20	mouse	mouse	VERB
bam-7218	686	21	derived	derive	VERB
bam-7218	686	22	satellite	satellite	NOUN
bam-7218	686	23	cells	cell	NOUN
bam-7218	686	24	by	by	ADP
bam-7218	686	25	a	a	DET
bam-7218	686	26	lentiviral	lentiviral	ADJ
bam-7218	686	27	vector	vector	NOUN
bam-7218	686	28	expressing	express	VERB
bam-7218	686	29	the	the	DET
bam-7218	686	30	wildtype	wildtype	NOUN
bam-7218	686	31	of	of	ADP
bam-7218	686	32	human	human	PROPN
bam-7218	686	33	fkrp	fkrp	PROPN
bam-7218	686	34	gene	gene	NOUN
bam-7218	686	35	.	.	PUNCT
bam-7218	687	1	moreover	moreover	ADV
bam-7218	687	2	,	,	PUNCT
bam-7218	687	3	we	we	PRON
bam-7218	687	4	showed	show	VERB
bam-7218	687	5	that	that	SCONJ
bam-7218	687	6	lv	lv	PROPN
bam-7218	687	7	-	-	PUNCT
bam-7218	687	8	fkrp	fkrp	NOUN
bam-7218	687	9	cells	cell	NOUN
bam-7218	687	10	were	be	AUX
bam-7218	687	11	driven	drive	VERB
bam-7218	687	12	to	to	PART
bam-7218	687	13	release	release	VERB
bam-7218	687	14	exosomes	exosome	NOUN
bam-7218	687	15	carrying	carry	VERB
bam-7218	687	16	fkrp	fkrp	NOUN
bam-7218	687	17	.	.	PUNCT
bam-7218	688	1	similarly	similarly	ADV
bam-7218	688	2	,	,	PUNCT
bam-7218	688	3	we	we	PRON
bam-7218	688	4	observed	observe	VERB
bam-7218	688	5	the	the	DET
bam-7218	688	6	presence	presence	NOUN
bam-7218	688	7	of	of	ADP
bam-7218	688	8	fkrp	fkrp	NOUN
bam-7218	688	9	positive	positive	ADJ
bam-7218	688	10	exosomes	exosome	NOUN
bam-7218	688	11	in	in	ADP
bam-7218	688	12	the	the	DET
bam-7218	688	13	plasma	plasma	NOUN
bam-7218	688	14	of	of	ADP
bam-7218	688	15	fkrp	fkrp	NOUN
bam-7218	688	16	l276iki	l276iki	PROPN
bam-7218	688	17	mice	mouse	NOUN
bam-7218	688	18	intramuscularly	intramuscularly	ADV
bam-7218	688	19	injected	inject	VERB
bam-7218	688	20	with	with	ADP
bam-7218	688	21	engineered	engineer	VERB
bam-7218	688	22	satellite	satellite	NOUN
bam-7218	688	23	cells	cell	NOUN
bam-7218	688	24	.	.	PUNCT
bam-7218	689	1	the	the	DET
bam-7218	689	2	distribution	distribution	NOUN
bam-7218	689	3	of	of	ADP
bam-7218	689	4	fkrp	fkrp	NOUN
bam-7218	689	5	protein	protein	NOUN
bam-7218	689	6	boosted	boost	VERB
bam-7218	689	7	by	by	ADP
bam-7218	689	8	exosomes	exosome	NOUN
bam-7218	689	9	determined	determine	VERB
bam-7218	689	10	its	its	PRON
bam-7218	689	11	restoration	restoration	NOUN
bam-7218	689	12	within	within	ADP
bam-7218	689	13	muscle	muscle	NOUN
bam-7218	689	14	tissues	tissue	NOUN
bam-7218	689	15	,	,	PUNCT
bam-7218	689	16	an	an	DET
bam-7218	689	17	overall	overall	ADJ
bam-7218	689	18	recovery	recovery	NOUN
bam-7218	689	19	of	of	ADP
bam-7218	689	20	α	α	NOUN
bam-7218	689	21	-	-	PUNCT
bam-7218	689	22	dg	dg	NOUN
bam-7218	689	23	glycosylation	glycosylation	NOUN
bam-7218	689	24	and	and	CCONJ
bam-7218	689	25	improved	improve	VERB
bam-7218	689	26	muscle	muscle	NOUN
bam-7218	689	27	strength	strength	NOUN
bam-7218	689	28	,	,	PUNCT
bam-7218	689	29	suggesting	suggest	VERB
bam-7218	689	30	a	a	DET
bam-7218	689	31	systemic	systemic	ADJ
bam-7218	689	32	supply	supply	NOUN
bam-7218	689	33	of	of	ADP
bam-7218	689	34	fkrp	fkrp	NOUN
bam-7218	689	35	protein	protein	NOUN
bam-7218	689	36	acting	act	VERB
bam-7218	689	37	as	as	ADP
bam-7218	689	38	glycosyltransferase	glycosyltransferase	NOUN
bam-7218	689	39	.	.	PUNCT
bam-7218	690	1	october	october	PROPN
bam-7218	690	2	14	14	NUM
bam-7218	690	3	th	th	NOUN
bam-7218	690	4	session	session	NOUN
bam-7218	690	5	7	7	NUM
bam-7218	690	6	muscle	muscle	NOUN
bam-7218	690	7	wasting	wasting	NOUN
bam-7218	690	8	,	,	PUNCT
bam-7218	690	9	sarcopenia	sarcopenia	NOUN
bam-7218	690	10	and	and	CCONJ
bam-7218	690	11	cachexia	cachexia	PROPN
bam-7218	690	12	7.1	7.1	NUM
bam-7218	690	13	inhibition	inhibition	NOUN
bam-7218	690	14	of	of	ADP
bam-7218	690	15	glutathione	glutathione	NOUN
bam-7218	690	16	peroxidase	peroxidase	NOUN
bam-7218	690	17	4	4	NUM
bam-7218	690	18	primes	prime	NOUN
bam-7218	690	19	mouse	mouse	NOUN
bam-7218	690	20	c2c12	c2c12	PROPN
bam-7218	690	21	myoblasts	myoblast	NOUN
bam-7218	690	22	and	and	CCONJ
bam-7218	690	23	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-7218	690	24	cell	cell	NOUN
bam-7218	690	25	lines	line	NOUN
bam-7218	690	26	to	to	PART
bam-7218	690	27	ferroptosis	ferroptosis	VERB
bam-7218	690	28	silvia	silvia	PROPN
bam-7218	690	29	codenotti	codenotti	PROPN
bam-7218	690	30	(	(	PUNCT
bam-7218	690	31	a	a	DET
bam-7218	690	32	,	,	PUNCT
bam-7218	690	33	b	b	NOUN
bam-7218	690	34	)	)	PUNCT
bam-7218	690	35	,	,	PUNCT
bam-7218	690	36	maura	maura	PROPN
bam-7218	690	37	poli	poli	PROPN
bam-7218	690	38	(	(	PUNCT
bam-7218	690	39	a	a	PROPN
bam-7218	690	40	)	)	PUNCT
bam-7218	690	41	,	,	PUNCT
bam-7218	690	42	michela	michela	PROPN
bam-7218	690	43	asperti	asperti	PROPN
bam-7218	690	44	(	(	PUNCT
bam-7218	690	45	a	a	PROPN
bam-7218	690	46	)	)	PUNCT
bam-7218	690	47	,	,	PUNCT
bam-7218	690	48	alessandro	alessandro	PROPN
bam-7218	690	49	fanzani	fanzani	PROPN
bam-7218	690	50	(	(	PUNCT
bam-7218	690	51	a	a	DET
bam-7218	690	52	,	,	PUNCT
bam-7218	690	53	b	b	NOUN
bam-7218	690	54	)	)	PUNCT
bam-7218	690	55	(	(	PUNCT
bam-7218	690	56	a	a	X
bam-7218	690	57	)	)	PUNCT
bam-7218	690	58	dept	dept	NOUN
bam-7218	690	59	of	of	ADP
bam-7218	690	60	molecular	molecular	ADJ
bam-7218	690	61	and	and	CCONJ
bam-7218	690	62	translational	translational	ADJ
bam-7218	690	63	medicine	medicine	NOUN
bam-7218	690	64	,	,	PUNCT
bam-7218	690	65	university	university	NOUN
bam-7218	690	66	of	of	ADP
bam-7218	690	67	brescia	brescia	PROPN
bam-7218	690	68	,	,	PUNCT
bam-7218	690	69	italy	italy	PROPN
bam-7218	690	70	;	;	PUNCT
bam-7218	690	71	(	(	PUNCT
bam-7218	690	72	b	b	X
bam-7218	690	73	)	)	PUNCT
bam-7218	690	74	interuniversity	interuniversity	NOUN
bam-7218	690	75	institute	institute	NOUN
bam-7218	690	76	of	of	ADP
bam-7218	690	77	myology	myology	NOUN
bam-7218	690	78	(	(	PUNCT
bam-7218	690	79	iim	iim	NOUN
bam-7218	690	80	)	)	PUNCT
bam-7218	690	81	,	,	PUNCT
bam-7218	690	82	rome	rome	PROPN
bam-7218	690	83	,	,	PUNCT
bam-7218	690	84	italy	italy	PROPN
bam-7218	690	85	.	.	PUNCT
bam-7218	691	1	e	e	X
bam-7218	691	2	-	-	NOUN
bam-7218	691	3	mail	mail	NOUN
bam-7218	691	4	:	:	PUNCT
bam-7218	691	5	silviacodenotti90@gmail.com	silviacodenotti90@gmail.com	X
bam-7218	691	6	ferroptosis	ferroptosis	NOUN
bam-7218	691	7	is	be	AUX
bam-7218	691	8	a	a	DET
bam-7218	691	9	recently	recently	ADV
bam-7218	691	10	discovered	discover	VERB
bam-7218	691	11	form	form	NOUN
bam-7218	691	12	of	of	ADP
bam-7218	691	13	cell	cell	NOUN
bam-7218	691	14	death	death	NOUN
bam-7218	691	15	causally	causally	ADV
bam-7218	691	16	linked	link	VERB
bam-7218	691	17	to	to	ADP
bam-7218	691	18	the	the	DET
bam-7218	691	19	ability	ability	NOUN
bam-7218	691	20	of	of	ADP
bam-7218	691	21	iron	iron	NOUN
bam-7218	691	22	to	to	PART
bam-7218	691	23	induce	induce	VERB
bam-7218	691	24	oxidative	oxidative	ADJ
bam-7218	691	25	damage	damage	NOUN
bam-7218	691	26	by	by	ADP
bam-7218	691	27	peroxidation	peroxidation	NOUN
bam-7218	691	28	of	of	ADP
bam-7218	691	29	polyunsaturated	polyunsaturated	ADJ
bam-7218	691	30	fatty	fatty	NOUN
bam-7218	691	31	acids	acid	NOUN
bam-7218	691	32	(	(	PUNCT
bam-7218	691	33	pufas	pufas	NOUN
bam-7218	691	34	)	)	PUNCT
bam-7218	691	35	.	.	PUNCT
bam-7218	692	1	misregulated	misregulated	ADJ
bam-7218	692	2	ferroptosis	ferroptosis	NOUN
bam-7218	692	3	has	have	AUX
bam-7218	692	4	been	be	AUX
bam-7218	692	5	implicated	implicate	VERB
bam-7218	692	6	in	in	ADP
bam-7218	692	7	a	a	DET
bam-7218	692	8	number	number	NOUN
bam-7218	692	9	of	of	ADP
bam-7218	692	10	pathological	pathological	ADJ
bam-7218	692	11	processes	process	NOUN
bam-7218	692	12	and	and	CCONJ
bam-7218	692	13	there	there	PRON
bam-7218	692	14	is	be	VERB
bam-7218	692	15	a	a	DET
bam-7218	692	16	growing	grow	VERB
bam-7218	692	17	interest	interest	NOUN
bam-7218	692	18	in	in	ADP
bam-7218	692	19	the	the	DET
bam-7218	692	20	pre	pre	ADJ
bam-7218	692	21	-	-	ADJ
bam-7218	692	22	clinical	clinical	ADJ
bam-7218	692	23	use	use	NOUN
bam-7218	692	24	of	of	ADP
bam-7218	692	25	ferroptosis	ferroptosis	NOUN
bam-7218	692	26	inducers	inducer	NOUN
bam-7218	692	27	against	against	ADP
bam-7218	692	28	tumors	tumor	NOUN
bam-7218	692	29	.	.	PUNCT
bam-7218	693	1	cells	cell	NOUN
bam-7218	693	2	to	to	PART
bam-7218	693	3	prevent	prevent	VERB
bam-7218	693	4	ferroptosis	ferroptosis	NOUN
bam-7218	693	5	mostly	mostly	ADV
bam-7218	693	6	engage	engage	VERB
bam-7218	693	7	in	in	ADP
bam-7218	693	8	the	the	DET
bam-7218	693	9	activity	activity	NOUN
bam-7218	693	10	of	of	ADP
bam-7218	693	11	glutathione	glutathione	NOUN
bam-7218	693	12	peroxidase	peroxidase	NOUN
bam-7218	693	13	4	4	NUM
bam-7218	693	14	(	(	PUNCT
bam-7218	693	15	gpx4	gpx4	PROPN
bam-7218	693	16	)	)	PUNCT
bam-7218	693	17	,	,	PUNCT
bam-7218	693	18	a	a	DET
bam-7218	693	19	selenoenzyme	selenoenzyme	NOUN
bam-7218	693	20	that	that	PRON
bam-7218	693	21	uses	use	VERB
bam-7218	693	22	glutathione	glutathione	NOUN
bam-7218	693	23	for	for	ADP
bam-7218	693	24	neutralizing	neutralize	VERB
bam-7218	693	25	lipid	lipid	NOUN
bam-7218	693	26	hydroperoxides	hydroperoxide	NOUN
bam-7218	693	27	.	.	PUNCT
bam-7218	694	1	two	two	NUM
bam-7218	694	2	major	major	ADJ
bam-7218	694	3	ferroptosis	ferroptosis	NOUN
bam-7218	694	4	inducers	inducer	NOUN
bam-7218	694	5	mediating	mediate	VERB
bam-7218	694	6	gpx4	gpx4	NOUN
bam-7218	694	7	inhibition	inhibition	NOUN
bam-7218	694	8	have	have	AUX
bam-7218	694	9	been	be	AUX
bam-7218	694	10	identified	identify	VERB
bam-7218	694	11	,	,	PUNCT
bam-7218	694	12	namely	namely	ADV
bam-7218	694	13	erastin	erastin	NOUN
bam-7218	694	14	(	(	PUNCT
bam-7218	694	15	eradicator	eradicator	NOUN
bam-7218	694	16	of	of	ADP
bam-7218	694	17	ras	ras	PROPN
bam-7218	694	18	and	and	CCONJ
bam-7218	694	19	st	st	NOUN
bam-7218	694	20	-	-	PUNCT
bam-7218	694	21	expressing	express	VERB
bam-7218	694	22	cells	cell	NOUN
bam-7218	694	23	)	)	PUNCT
bam-7218	694	24	and	and	CCONJ
bam-7218	694	25	rsl3	rsl3	PROPN
bam-7218	694	26	(	(	PUNCT
bam-7218	694	27	ras	ras	X
bam-7218	694	28	selective	selective	ADJ
bam-7218	694	29	lethal	lethal	ADJ
bam-7218	694	30	3	3	NUM
bam-7218	694	31	)	)	PUNCT
bam-7218	694	32	.	.	PUNCT
bam-7218	695	1	in	in	ADP
bam-7218	695	2	this	this	DET
bam-7218	695	3	work	work	NOUN
bam-7218	695	4	we	we	PRON
bam-7218	695	5	have	have	AUX
bam-7218	695	6	investigated	investigate	VERB
bam-7218	695	7	their	their	PRON
bam-7218	695	8	effect	effect	NOUN
bam-7218	695	9	on	on	ADP
bam-7218	695	10	mouse	mouse	NOUN
bam-7218	695	11	skeletal	skeletal	ADJ
bam-7218	695	12	c2c12	c2c12	PROPN
bam-7218	695	13	myoblasts	myoblast	NOUN
bam-7218	695	14	and	and	CCONJ
bam-7218	695	15	cell	cell	NOUN
bam-7218	695	16	lines	line	NOUN
bam-7218	695	17	of	of	ADP
bam-7218	695	18	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-7218	695	19	(	(	PUNCT
bam-7218	695	20	rms	rm	NOUN
bam-7218	695	21	)	)	PUNCT
bam-7218	695	22	,	,	PUNCT
bam-7218	695	23	the	the	DET
bam-7218	695	24	most	most	ADV
bam-7218	695	25	frequent	frequent	ADJ
bam-7218	695	26	softtissue	softtissue	NOUN
bam-7218	695	27	tumor	tumor	NOUN
bam-7218	695	28	affecting	affect	VERB
bam-7218	695	29	children	child	NOUN
bam-7218	695	30	and	and	CCONJ
bam-7218	695	31	adolescents	adolescent	NOUN
bam-7218	695	32	.	.	PUNCT
bam-7218	696	1	as	as	SCONJ
bam-7218	696	2	evaluated	evaluate	VERB
bam-7218	696	3	by	by	ADP
bam-7218	696	4	using	use	VERB
bam-7218	696	5	specific	specific	ADJ
bam-7218	696	6	fluorescent	fluorescent	ADJ
bam-7218	696	7	probes	probe	NOUN
bam-7218	696	8	,	,	PUNCT
bam-7218	696	9	treatment	treatment	NOUN
bam-7218	696	10	with	with	ADP
bam-7218	696	11	erastin	erastin	NOUN
bam-7218	696	12	or	or	CCONJ
bam-7218	696	13	rsl3	rsl3	ADJ
bam-7218	696	14	agents	agent	NOUN
bam-7218	696	15	resulted	result	VERB
bam-7218	696	16	in	in	ADP
bam-7218	696	17	a	a	DET
bam-7218	696	18	marked	mark	VERB
bam-7218	696	19	production	production	NOUN
bam-7218	696	20	of	of	ADP
bam-7218	696	21	both	both	CCONJ
bam-7218	696	22	cytoplasmic	cytoplasmic	ADJ
bam-7218	696	23	/	/	SYM
bam-7218	696	24	mitochondrial	mitochondrial	ADJ
bam-7218	696	25	ros	ro	NOUN
bam-7218	696	26	and	and	CCONJ
bam-7218	696	27	lipid	lipid	PROPN
bam-7218	696	28	ros	ros	PROPN
bam-7218	696	29	,	,	PUNCT
bam-7218	696	30	which	which	PRON
bam-7218	696	31	correlated	correlate	VERB
bam-7218	696	32	in	in	ADP
bam-7218	696	33	a	a	DET
bam-7218	696	34	dosedependent	dosedependent	NOUN
bam-7218	696	35	manner	manner	NOUN
bam-7218	696	36	with	with	ADP
bam-7218	696	37	a	a	DET
bam-7218	696	38	decreased	decrease	VERB
bam-7218	696	39	cell	cell	NOUN
bam-7218	696	40	viability	viability	NOUN
bam-7218	696	41	,	,	PUNCT
bam-7218	696	42	as	as	SCONJ
bam-7218	696	43	evaluated	evaluate	VERB
bam-7218	696	44	by	by	ADP
bam-7218	696	45	means	mean	NOUN
bam-7218	696	46	of	of	ADP
bam-7218	696	47	neutral	neutral	ADJ
bam-7218	696	48	red	red	ADJ
bam-7218	696	49	assays	assay	NOUN
bam-7218	696	50	after	after	ADP
bam-7218	696	51	48	48	NUM
bam-7218	696	52	hours	hour	NOUN
bam-7218	696	53	.	.	PUNCT
bam-7218	697	1	in	in	ADP
bam-7218	697	2	erastin	erastin	NOUN
bam-7218	697	3	-	-	PUNCT
bam-7218	697	4	treated	treat	VERB
bam-7218	697	5	cell	cell	NOUN
bam-7218	697	6	lines	line	NOUN
bam-7218	697	7	ferroptosis	ferroptosis	NOUN
bam-7218	697	8	was	be	AUX
bam-7218	697	9	enhanced	enhance	VERB
bam-7218	697	10	in	in	ADP
bam-7218	697	11	the	the	DET
bam-7218	697	12	presence	presence	NOUN
bam-7218	697	13	of	of	ADP
bam-7218	697	14	iron	iron	NOUN
bam-7218	697	15	supplementation	supplementation	NOUN
bam-7218	697	16	(	(	PUNCT
bam-7218	697	17	through	through	ADP
bam-7218	697	18	ferric	ferric	ADJ
bam-7218	697	19	ammonium	ammonium	NOUN
bam-7218	697	20	citrate	citrate	NOUN
bam-7218	697	21	)	)	PUNCT
bam-7218	697	22	,	,	PUNCT
bam-7218	697	23	while	while	SCONJ
bam-7218	697	24	it	it	PRON
bam-7218	697	25	was	be	AUX
bam-7218	697	26	prevented	prevent	VERB
bam-7218	697	27	by	by	ADP
bam-7218	697	28	pre	pre	ADJ
bam-7218	697	29	-	-	NOUN
bam-7218	697	30	treatment	treatment	NOUN
bam-7218	697	31	with	with	ADP
bam-7218	697	32	agents	agent	NOUN
bam-7218	697	33	sequestering	sequester	VERB
bam-7218	697	34	iron	iron	NOUN
bam-7218	697	35	(	(	PUNCT
bam-7218	697	36	bathophenanthrolinedisulfonic	bathophenanthrolinedisulfonic	ADJ
bam-7218	697	37	acid	acid	NOUN
bam-7218	697	38	)	)	PUNCT
bam-7218	697	39	,	,	PUNCT
bam-7218	697	40	antioxidant	antioxidant	ADJ
bam-7218	697	41	mailto:yvan.torrente@unimi.it	mailto:yvan.torrente@unimi.it	PROPN
bam-7218	697	42	mailto:silviacodenotti90@gmail.com	mailto:silviacodenotti90@gmail.com	PROPN
bam-7218	697	43	14	14	NUM
bam-7218	697	44	th	th	NOUN
bam-7218	697	45	iiim	iiim	NOUN
bam-7218	697	46	meeting	meeting	NOUN
bam-7218	697	47	,	,	PUNCT
bam-7218	697	48	assisi	assisi	PROPN
bam-7218	697	49	,	,	PUNCT
bam-7218	697	50	italy	italy	PROPN
bam-7218	697	51	october	october	PROPN
bam-7218	697	52	12	12	NUM
bam-7218	697	53	-	-	SYM
bam-7218	697	54	15	15	NUM
bam-7218	697	55	2017	2017	NUM
bam-7218	697	56	eur	eur	PROPN
bam-7218	697	57	j	j	PROPN
bam-7218	697	58	transl	transl	PROPN
bam-7218	697	59	myol	myol	ADV
bam-7218	697	60	27	27	NUM
bam-7218	697	61	(	(	PUNCT
bam-7218	697	62	4	4	NUM
bam-7218	697	63	):	):	SYM
bam-7218	697	64	185	185	NUM
bam-7218	697	65	-	-	SYM
bam-7218	697	66	224	224	NUM
bam-7218	697	67	206	206	NUM
bam-7218	697	68	scavengers	scavenger	NOUN
bam-7218	697	69	(	(	PUNCT
bam-7218	697	70	glutathione	glutathione	NOUN
bam-7218	697	71	and	and	CCONJ
bam-7218	697	72	n	n	CCONJ
bam-7218	697	73	-	-	PUNCT
bam-7218	697	74	acetylcysteine	acetylcysteine	NOUN
bam-7218	697	75	)	)	PUNCT
bam-7218	697	76	and	and	CCONJ
bam-7218	697	77	lipid	lipid	PROPN
bam-7218	697	78	ros	ros	PROPN
bam-7218	697	79	scavengers	scavenger	NOUN
bam-7218	697	80	(	(	PUNCT
bam-7218	697	81	ferrostatin-1	ferrostatin-1	PROPN
bam-7218	697	82	)	)	PUNCT
bam-7218	697	83	.	.	PUNCT
bam-7218	698	1	we	we	PRON
bam-7218	698	2	observed	observe	VERB
bam-7218	698	3	erastin	erastin	NOUN
bam-7218	698	4	to	to	PART
bam-7218	698	5	be	be	AUX
bam-7218	698	6	more	more	ADV
bam-7218	698	7	effective	effective	ADJ
bam-7218	698	8	to	to	PART
bam-7218	698	9	promote	promote	VERB
bam-7218	698	10	ferroptosis	ferroptosis	NOUN
bam-7218	698	11	in	in	ADP
bam-7218	698	12	the	the	DET
bam-7218	698	13	cell	cell	NOUN
bam-7218	698	14	lines	line	NOUN
bam-7218	698	15	showing	show	VERB
bam-7218	698	16	a	a	DET
bam-7218	698	17	higher	high	ADJ
bam-7218	698	18	proliferation	proliferation	NOUN
bam-7218	698	19	rate	rate	NOUN
bam-7218	698	20	.	.	PUNCT
bam-7218	699	1	indeed	indeed	ADV
bam-7218	699	2	,	,	PUNCT
bam-7218	699	3	inhibition	inhibition	NOUN
bam-7218	699	4	of	of	ADP
bam-7218	699	5	erk	erk	NOUN
bam-7218	699	6	signaling	signal	VERB
bam-7218	699	7	,	,	PUNCT
bam-7218	699	8	as	as	SCONJ
bam-7218	699	9	observed	observe	VERB
bam-7218	699	10	during	during	ADP
bam-7218	699	11	differentiation	differentiation	NOUN
bam-7218	699	12	or	or	CCONJ
bam-7218	699	13	upon	upon	SCONJ
bam-7218	699	14	pharmacological	pharmacological	ADJ
bam-7218	699	15	treatment	treatment	NOUN
bam-7218	699	16	with	with	ADP
bam-7218	699	17	pd090859	pd090859	PROPN
bam-7218	699	18	agent	agent	NOUN
bam-7218	699	19	,	,	PUNCT
bam-7218	699	20	prevented	prevent	VERB
bam-7218	699	21	ferroptosis	ferroptosis	NOUN
bam-7218	699	22	in	in	ADP
bam-7218	699	23	erastin	erastin	NOUN
bam-7218	699	24	-	-	PUNCT
bam-7218	699	25	treated	treat	VERB
bam-7218	699	26	human	human	ADJ
bam-7218	699	27	rms	rm	NOUN
bam-7218	699	28	embryonal	embryonal	PROPN
bam-7218	699	29	rd	rd	PROPN
bam-7218	699	30	and	and	CCONJ
bam-7218	699	31	c2c12	c2c12	PROPN
bam-7218	699	32	cell	cell	NOUN
bam-7218	699	33	lines	line	NOUN
bam-7218	699	34	.	.	PUNCT
bam-7218	700	1	furthermore	furthermore	ADV
bam-7218	700	2	,	,	PUNCT
bam-7218	700	3	we	we	PRON
bam-7218	700	4	found	find	VERB
bam-7218	700	5	erastin	erastin	NOUN
bam-7218	700	6	and	and	CCONJ
bam-7218	700	7	rsl3	rsl3	PROPN
bam-7218	700	8	to	to	PART
bam-7218	700	9	be	be	AUX
bam-7218	700	10	more	more	ADV
bam-7218	700	11	effective	effective	ADJ
bam-7218	700	12	in	in	ADP
bam-7218	700	13	inducing	induce	VERB
bam-7218	700	14	ferroptosis	ferroptosis	NOUN
bam-7218	700	15	in	in	ADP
bam-7218	700	16	rd	rd	NOUN
bam-7218	700	17	subclones	subclone	NOUN
bam-7218	700	18	characterized	characterize	VERB
bam-7218	700	19	by	by	ADP
bam-7218	700	20	higher	high	ADJ
bam-7218	700	21	erk1/2	erk1/2	PROPN
bam-7218	700	22	phosphorylation	phosphorylation	NOUN
bam-7218	700	23	and	and	CCONJ
bam-7218	700	24	proliferation	proliferation	NOUN
bam-7218	700	25	rate	rate	NOUN
bam-7218	700	26	.	.	PUNCT
bam-7218	701	1	taken	take	VERB
bam-7218	701	2	together	together	ADV
bam-7218	701	3	,	,	PUNCT
bam-7218	701	4	our	our	PRON
bam-7218	701	5	data	datum	NOUN
bam-7218	701	6	suggest	suggest	VERB
bam-7218	701	7	that	that	SCONJ
bam-7218	701	8	iron	iron	NOUN
bam-7218	701	9	metabolism	metabolism	NOUN
bam-7218	701	10	could	could	AUX
bam-7218	701	11	play	play	VERB
bam-7218	701	12	a	a	DET
bam-7218	701	13	key	key	ADJ
bam-7218	701	14	role	role	NOUN
bam-7218	701	15	in	in	ADP
bam-7218	701	16	the	the	DET
bam-7218	701	17	cell	cell	NOUN
bam-7218	701	18	fate	fate	NOUN
bam-7218	701	19	of	of	ADP
bam-7218	701	20	muscle	muscle	NOUN
bam-7218	701	21	cells	cell	NOUN
bam-7218	701	22	;	;	PUNCT
bam-7218	701	23	in	in	ADP
bam-7218	701	24	addition	addition	NOUN
bam-7218	701	25	,	,	PUNCT
bam-7218	701	26	the	the	DET
bam-7218	701	27	use	use	NOUN
bam-7218	701	28	of	of	ADP
bam-7218	701	29	ferroptotic	ferroptotic	ADJ
bam-7218	701	30	inducers	inducer	NOUN
bam-7218	701	31	could	could	AUX
bam-7218	701	32	offer	offer	VERB
bam-7218	701	33	a	a	DET
bam-7218	701	34	novel	novel	ADJ
bam-7218	701	35	alternative	alternative	NOUN
bam-7218	701	36	to	to	PART
bam-7218	701	37	improve	improve	VERB
bam-7218	701	38	the	the	DET
bam-7218	701	39	efficacy	efficacy	NOUN
bam-7218	701	40	of	of	ADP
bam-7218	701	41	conventional	conventional	ADJ
bam-7218	701	42	antineoplastic	antineoplastic	ADJ
bam-7218	701	43	cocktails	cocktail	NOUN
bam-7218	701	44	utilized	utilize	VERB
bam-7218	701	45	against	against	ADP
bam-7218	701	46	rms	rm	NOUN
bam-7218	701	47	.	.	PROPN
bam-7218	702	1	7.2	7.2	NUM
bam-7218	702	2	micro	micro	ADJ
bam-7218	702	3	-	-	ADJ
bam-7218	702	4	computed	compute	VERB
bam-7218	702	5	tomography	tomography	NOUN
bam-7218	702	6	
	
	SPACE
bam-7218	702	7	for	for	ADP
bam-7218	702	8	non	non	ADJ
bam-7218	702	9	-	-	ADJ
bam-7218	702	10	invasive	invasive	ADJ
bam-7218	702	11	evaluation	evaluation	NOUN
bam-7218	702	12	of	of	ADP
bam-7218	702	13	muscle	muscle	NOUN
bam-7218	702	14	atrophy	atrophy	NOUN
bam-7218	702	15	
	
	SPACE
bam-7218	702	16	in	in	ADP
bam-7218	702	17	mouse	mouse	NOUN
bam-7218	702	18	models	model	NOUN
bam-7218	702	19	of	of	ADP
bam-7218	702	20	neuromuscular	neuromuscular	ADJ
bam-7218	702	21	disease	disease	NOUN
bam-7218	702	22	and	and	CCONJ
bam-7218	702	23	cancer	cancer	NOUN
bam-7218	702	24	cachexia	cachexia	PROPN
bam-7218	702	25	laura	laura	PROPN
bam-7218	702	26	pasetto	pasetto	PROPN
bam-7218	702	27	(	(	PUNCT
bam-7218	702	28	a	a	NOUN
bam-7218	702	29	)	)	PUNCT
bam-7218	702	30	*	*	ADJ
bam-7218	702	31	,	,	PUNCT
bam-7218	702	32	davide	davide	ADJ
bam-7218	702	33	olivari	olivari	NOUN
bam-7218	702	34	(	(	PUNCT
bam-7218	702	35	b	b	NOUN
bam-7218	702	36	)	)	PUNCT
bam-7218	702	37	*	*	PUNCT
bam-7218	702	38	,	,	PUNCT
bam-7218	702	39	giovanni	giovanni	PROPN
bam-7218	702	40	nardo	nardo	PROPN
bam-7218	702	41	(	(	PUNCT
bam-7218	702	42	c	c	NOUN
bam-7218	702	43	)	)	PUNCT
bam-7218	702	44	,	,	PUNCT
bam-7218	702	45	caterina	caterina	PROPN
bam-7218	702	46	bendotti	bendotti	PROPN
bam-7218	702	47	(	(	PUNCT
bam-7218	702	48	c	c	NOUN
bam-7218	702	49	)	)	PUNCT
bam-7218	702	50	,	,	PUNCT
bam-7218	702	51	rosanna	rosanna	NOUN
bam-7218	702	52	piccirillo	piccirillo	NOUN
bam-7218	702	53	(	(	PUNCT
bam-7218	702	54	b	b	NOUN
bam-7218	702	55	)	)	PUNCT
bam-7218	702	56	#	#	PROPN
bam-7218	702	57	,	,	PUNCT
bam-7218	702	58	valentina	valentina	NOUN
bam-7218	702	59	bonetto	bonetto	NOUN
bam-7218	702	60	(	(	PUNCT
bam-7218	702	61	a	a	X
bam-7218	702	62	)	)	PUNCT
bam-7218	702	63	#	#	NOUN
bam-7218	702	64	(	(	PUNCT
bam-7218	702	65	a	a	NOUN
bam-7218	702	66	)	)	PUNCT
bam-7218	702	67	irccs	irccs	NOUN
bam-7218	702	68	-	-	PUNCT
bam-7218	702	69	istituto	istituto	X
bam-7218	702	70	di	di	X
bam-7218	702	71	ricerche	ricerche	PROPN
bam-7218	702	72	farmacologiche	farmacologiche	PROPN
bam-7218	702	73	mario	mario	PROPN
bam-7218	702	74	negri	negri	PROPN
bam-7218	702	75	/	/	SYM
bam-7218	702	76	dept	dept	NOUN
bam-7218	702	77	of	of	ADP
bam-7218	702	78	molecular	molecular	ADJ
bam-7218	702	79	biochemistry	biochemistry	NOUN
bam-7218	702	80	and	and	CCONJ
bam-7218	702	81	pharmacology	pharmacology	NOUN
bam-7218	702	82	,	,	PUNCT
bam-7218	702	83	milan	milan	PROPN
bam-7218	702	84	,	,	PUNCT
bam-7218	702	85	italy	italy	PROPN
bam-7218	702	86	;	;	PUNCT
bam-7218	702	87	
	
	SPACE
bam-7218	702	88	(	(	PUNCT
bam-7218	702	89	b	b	NOUN
bam-7218	702	90	)	)	PUNCT
bam-7218	702	91	irccs	irccs	NOUN
bam-7218	702	92	-	-	PUNCT
bam-7218	702	93	istituto	istituto	X
bam-7218	702	94	di	di	X
bam-7218	702	95	ricerche	ricerche	PROPN
bam-7218	702	96	farmacologiche	farmacologiche	PROPN
bam-7218	702	97	mario	mario	PROPN
bam-7218	702	98	negri	negri	PROPN
bam-7218	702	99	/	/	SYM
bam-7218	702	100	dept	dept	NOUN
bam-7218	702	101	of	of	ADP
bam-7218	702	102	oncology	oncology	NOUN
bam-7218	702	103	,	,	PUNCT
bam-7218	702	104	milan	milan	PROPN
bam-7218	702	105	,	,	PUNCT
bam-7218	702	106	italy	italy	PROPN
bam-7218	702	107	.	.	PUNCT
bam-7218	702	108	
	
	SPACE
bam-7218	702	109	circcs	circcs	NOUN
bam-7218	702	110	-	-	PUNCT
bam-7218	702	111	istituto	istituto	X
bam-7218	702	112	di	di	X
bam-7218	702	113	ricerche	ricerche	PROPN
bam-7218	702	114	farmacologiche	farmacologiche	PROPN
bam-7218	702	115	mario	mario	PROPN
bam-7218	702	116	negri	negri	PROPN
bam-7218	702	117	/	/	SYM
bam-7218	702	118	dept	dept	NOUN
bam-7218	702	119	of	of	ADP
bam-7218	702	120	neurosciences	neuroscience	NOUN
bam-7218	702	121	,	,	PUNCT
bam-7218	702	122	milan	milan	PROPN
bam-7218	702	123	,	,	PUNCT
bam-7218	702	124	italy	italy	PROPN
bam-7218	702	125	.	.	PUNCT
bam-7218	703	1	e	e	X
bam-7218	703	2	-	-	NOUN
bam-7218	703	3	mail	mail	NOUN
bam-7218	703	4	:	:	PUNCT
bam-7218	703	5	rosanna.piccirillo7@gmail.com	rosanna.piccirillo7@gmail.com	X
bam-7218	704	1	muscle	muscle	NOUN
bam-7218	704	2	wasting	waste	VERB
bam-7218	704	3	occurs	occur	VERB
bam-7218	704	4	during	during	ADP
bam-7218	704	5	various	various	ADJ
bam-7218	704	6	chronic	chronic	ADJ
bam-7218	704	7	diseases	disease	NOUN
bam-7218	704	8	and	and	CCONJ
bam-7218	704	9	precedes	precede	VERB
bam-7218	704	10	death	death	NOUN
bam-7218	704	11	in	in	ADP
bam-7218	704	12	humans	human	NOUN
bam-7218	704	13	as	as	ADP
bam-7218	704	14	in	in	ADP
bam-7218	704	15	mice	mouse	NOUN
bam-7218	704	16	.	.	PUNCT
bam-7218	705	1	assessing	assess	VERB
bam-7218	705	2	the	the	DET
bam-7218	705	3	degree	degree	NOUN
bam-7218	705	4	of	of	ADP
bam-7218	705	5	muscle	muscle	NOUN
bam-7218	705	6	atrophy	atrophy	NOUN
bam-7218	705	7	in	in	ADP
bam-7218	705	8	diseased	diseased	ADJ
bam-7218	705	9	mouse	mouse	NOUN
bam-7218	705	10	models	model	NOUN
bam-7218	705	11	is	be	AUX
bam-7218	705	12	often	often	ADV
bam-7218	705	13	overlooked	overlook	VERB
bam-7218	705	14	since	since	SCONJ
bam-7218	705	15	it	it	PRON
bam-7218	705	16	requires	require	VERB
bam-7218	705	17	the	the	DET
bam-7218	705	18	sacrifice	sacrifice	NOUN
bam-7218	705	19	of	of	ADP
bam-7218	705	20	the	the	DET
bam-7218	705	21	animals	animal	NOUN
bam-7218	705	22	for	for	ADP
bam-7218	705	23	muscle	muscle	NOUN
bam-7218	705	24	examination	examination	NOUN
bam-7218	705	25	or	or	CCONJ
bam-7218	705	26	expensive	expensive	ADJ
bam-7218	705	27	instrumentation	instrumentation	NOUN
bam-7218	705	28	and	and	CCONJ
bam-7218	705	29	highly	highly	ADV
bam-7218	705	30	qualified	qualified	ADJ
bam-7218	705	31	personnel	personnel	NOUN
bam-7218	705	32	,	,	PUNCT
bam-7218	705	33	such	such	ADJ
bam-7218	705	34	as	as	ADP
bam-7218	705	35	magnetic	magnetic	ADJ
bam-7218	705	36	resonance	resonance	NOUN
bam-7218	705	37	imaging	imaging	NOUN
bam-7218	705	38	(	(	PUNCT
bam-7218	705	39	mri	mri	NOUN
bam-7218	705	40	)	)	PUNCT
bam-7218	705	41	.	.	PUNCT
bam-7218	706	1	we	we	PRON
bam-7218	706	2	developed	develop	VERB
bam-7218	706	3	a	a	DET
bam-7218	706	4	non	non	ADJ
bam-7218	706	5	-	-	ADJ
bam-7218	706	6	invasive	invasive	ADJ
bam-7218	706	7	procedure	procedure	NOUN
bam-7218	706	8	based	base	VERB
bam-7218	706	9	on	on	ADP
bam-7218	706	10	micro	micro	ADJ
bam-7218	706	11	-	-	ADJ
bam-7218	706	12	computed	computed	ADJ
bam-7218	706	13	tomography	tomography	NOUN
bam-7218	706	14	(	(	PUNCT
bam-7218	706	15	micro	micro	NOUN
bam-7218	706	16	-	-	NOUN
bam-7218	706	17	ct	ct	NOUN
bam-7218	706	18	)	)	PUNCT
bam-7218	706	19	without	without	ADP
bam-7218	706	20	contrast	contrast	NOUN
bam-7218	706	21	agents	agent	NOUN
bam-7218	706	22	to	to	PART
bam-7218	706	23	monitor	monitor	VERB
bam-7218	706	24	hind	hind	NOUN
bam-7218	706	25	limb	limb	NOUN
bam-7218	706	26	muscle	muscle	NOUN
bam-7218	706	27	wasting	waste	VERB
bam-7218	706	28	in	in	ADP
bam-7218	706	29	mouse	mouse	NOUN
bam-7218	706	30	models	model	NOUN
bam-7218	706	31	of	of	ADP
bam-7218	706	32	neuromuscular	neuromuscular	ADJ
bam-7218	706	33	disease	disease	NOUN
bam-7218	706	34	and	and	CCONJ
bam-7218	706	35	cancer	cancer	NOUN
bam-7218	706	36	cachexia	cachexia	NOUN
bam-7218	706	37	:	:	PUNCT
bam-7218	706	38	the	the	DET
bam-7218	706	39	transgenic	transgenic	NOUN
bam-7218	706	40	sod1g93a	sod1g93a	NUM
bam-7218	706	41	mouse	mouse	NOUN
bam-7218	706	42	and	and	CCONJ
bam-7218	706	43	the	the	DET
bam-7218	706	44	colon	colon	NOUN
bam-7218	706	45	adenocarcinoma	adenocarcinoma	NOUN
bam-7218	706	46	c26	c26	NOUN
bam-7218	706	47	-	-	PUNCT
bam-7218	706	48	bearing	bear	VERB
bam-7218	706	49	mouse	mouse	NOUN
bam-7218	706	50	,	,	PUNCT
bam-7218	706	51	respectively	respectively	ADV
bam-7218	706	52	.	.	PUNCT
bam-7218	707	1	we	we	PRON
bam-7218	707	2	established	establish	VERB
bam-7218	707	3	the	the	DET
bam-7218	707	4	scanning	scanning	NOUN
bam-7218	707	5	procedure	procedure	NOUN
bam-7218	707	6	and	and	CCONJ
bam-7218	707	7	the	the	DET
bam-7218	707	8	parameters	parameter	NOUN
bam-7218	707	9	to	to	PART
bam-7218	707	10	consider	consider	VERB
bam-7218	707	11	in	in	ADP
bam-7218	707	12	the	the	DET
bam-7218	707	13	reconstructed	reconstruct	VERB
bam-7218	707	14	images	image	NOUN
bam-7218	707	15	to	to	PART
bam-7218	707	16	calculate	calculate	VERB
bam-7218	707	17	the	the	DET
bam-7218	707	18	index	index	NOUN
bam-7218	707	19	of	of	ADP
bam-7218	707	20	muscle	muscle	NOUN
bam-7218	707	21	mass	mass	PROPN
bam-7218	707	22	(	(	PUNCT
bam-7218	707	23	imm	imm	NOUN
bam-7218	707	24	)	)	PUNCT
bam-7218	707	25	.	.	PUNCT
bam-7218	708	1	we	we	PRON
bam-7218	708	2	performed	perform	VERB
bam-7218	708	3	longitudinally	longitudinally	PROPN
bam-7218	708	4	micro	micro	PROPN
bam-7218	708	5	-	-	PROPN
bam-7218	708	6	ct	ct	ADJ
bam-7218	708	7	scan	scan	NOUN
bam-7218	708	8	of	of	ADP
bam-7218	708	9	hind	hind	NOUN
bam-7218	708	10	limbs	limb	NOUN
bam-7218	708	11	in	in	ADP
bam-7218	708	12	sod1g93a	sod1g93a	NUM
bam-7218	708	13	mice	mouse	NOUN
bam-7218	708	14	at	at	ADP
bam-7218	708	15	presymptomatic	presymptomatic	ADJ
bam-7218	708	16	and	and	CCONJ
bam-7218	708	17	symptomatic	symptomatic	ADJ
bam-7218	708	18	stages	stage	NOUN
bam-7218	708	19	of	of	ADP
bam-7218	708	20	the	the	DET
bam-7218	708	21	disease	disease	NOUN
bam-7218	708	22	and	and	CCONJ
bam-7218	708	23	calculated	calculate	VERB
bam-7218	708	24	the	the	DET
bam-7218	708	25	imm	imm	NOUN
bam-7218	708	26	.	.	PUNCT
bam-7218	709	1	we	we	PRON
bam-7218	709	2	found	find	VERB
bam-7218	709	3	that	that	SCONJ
bam-7218	709	4	imm	imm	NOUN
bam-7218	709	5	in	in	ADP
bam-7218	709	6	sod1g93a	sod1g93a	NUM
bam-7218	709	7	mice	mouse	NOUN
bam-7218	709	8	was	be	AUX
bam-7218	709	9	lower	low	ADJ
bam-7218	709	10	than	than	ADP
bam-7218	709	11	agematched	agematched	ADJ
bam-7218	709	12	controls	control	NOUN
bam-7218	709	13	even	even	ADV
bam-7218	709	14	before	before	ADP
bam-7218	709	15	symptom	symptom	NOUN
bam-7218	709	16	onset	onset	NOUN
bam-7218	709	17	.	.	PUNCT
bam-7218	710	1	we	we	PRON
bam-7218	710	2	also	also	ADV
bam-7218	710	3	detected	detect	VERB
bam-7218	710	4	a	a	DET
bam-7218	710	5	further	further	ADJ
bam-7218	710	6	decrease	decrease	NOUN
bam-7218	710	7	in	in	ADP
bam-7218	710	8	imm	imm	NOUN
bam-7218	710	9	as	as	SCONJ
bam-7218	710	10	disease	disease	NOUN
bam-7218	710	11	progresses	progress	VERB
bam-7218	710	12	,	,	PUNCT
bam-7218	710	13	most	most	ADV
bam-7218	710	14	markedly	markedly	ADV
bam-7218	710	15	just	just	ADV
bam-7218	710	16	before	before	SCONJ
bam-7218	710	17	disease	disease	NOUN
bam-7218	710	18	onset	onset	VERB
bam-7218	710	19	.	.	PUNCT
bam-7218	711	1	we	we	PRON
bam-7218	711	2	performed	perform	VERB
bam-7218	711	3	the	the	DET
bam-7218	711	4	same	same	ADJ
bam-7218	711	5	analyses	analysis	NOUN
bam-7218	711	6	in	in	ADP
bam-7218	711	7	the	the	DET
bam-7218	711	8	c26	c26	NOUN
bam-7218	711	9	-	-	PUNCT
bam-7218	711	10	based	base	VERB
bam-7218	711	11	mouse	mouse	NOUN
bam-7218	711	12	model	model	NOUN
bam-7218	711	13	,	,	PUNCT
bam-7218	711	14	losing	lose	VERB
bam-7218	711	15	progressively	progressively	ADV
bam-7218	711	16	body	body	NOUN
bam-7218	711	17	and	and	CCONJ
bam-7218	711	18	muscle	muscle	NOUN
bam-7218	711	19	mass	mass	NOUN
bam-7218	711	20	because	because	SCONJ
bam-7218	711	21	of	of	ADP
bam-7218	711	22	cachexia	cachexia	NOUN
bam-7218	711	23	.	.	PUNCT
bam-7218	712	1	interestingly	interestingly	ADV
bam-7218	712	2	,	,	PUNCT
bam-7218	712	3	we	we	PRON
bam-7218	712	4	found	find	VERB
bam-7218	712	5	a	a	DET
bam-7218	712	6	strong	strong	ADJ
bam-7218	712	7	correlation	correlation	NOUN
bam-7218	712	8	between	between	ADP
bam-7218	712	9	imm	imm	NOUN
bam-7218	712	10	and	and	CCONJ
bam-7218	712	11	tibialis	tibialis	NOUN
bam-7218	712	12	anterior	anterior	ADJ
bam-7218	712	13	and	and	CCONJ
bam-7218	712	14	gastrocnemius	gastrocnemius	ADJ
bam-7218	712	15	muscle	muscle	NOUN
bam-7218	712	16	weights	weight	NOUN
bam-7218	712	17	in	in	ADP
bam-7218	712	18	both	both	DET
bam-7218	712	19	disease	disease	NOUN
bam-7218	712	20	models	model	NOUN
bam-7218	712	21	.	.	PUNCT
bam-7218	713	1	we	we	PRON
bam-7218	713	2	developed	develop	VERB
bam-7218	713	3	a	a	DET
bam-7218	713	4	fast	fast	ADJ
bam-7218	713	5	,	,	PUNCT
bam-7218	713	6	easy	easy	ADJ
bam-7218	713	7	-	-	PUNCT
bam-7218	713	8	to	to	ADP
bam-7218	713	9	-	-	PUNCT
bam-7218	713	10	conduct	conduct	VERB
bam-7218	713	11	and	and	CCONJ
bam-7218	713	12	cost	cost	NOUN
bam-7218	713	13	-	-	PUNCT
bam-7218	713	14	effective	effective	ADJ
bam-7218	713	15	imaging	imaging	NOUN
bam-7218	713	16	procedure	procedure	NOUN
bam-7218	713	17	to	to	PART
bam-7218	713	18	monitor	monitor	VERB
bam-7218	713	19	hind	hind	NOUN
bam-7218	713	20	limb	limb	NOUN
bam-7218	713	21	muscle	muscle	NOUN
bam-7218	713	22	mass	mass	NOUN
bam-7218	713	23	useful	useful	ADJ
bam-7218	713	24	in	in	ADP
bam-7218	713	25	preclinical	preclinical	ADJ
bam-7218	713	26	therapeutic	therapeutic	ADJ
bam-7218	713	27	trials	trial	NOUN
bam-7218	713	28	but	but	CCONJ
bam-7218	713	29	also	also	ADV
bam-7218	713	30	in	in	ADP
bam-7218	713	31	proofof	proofof	ADJ
bam-7218	713	32	-	-	PUNCT
bam-7218	713	33	principle	principle	NOUN
bam-7218	713	34	studies	study	NOUN
bam-7218	713	35	to	to	PART
bam-7218	713	36	identify	identify	VERB
bam-7218	713	37	the	the	DET
bam-7218	713	38	onset	onset	NOUN
bam-7218	713	39	of	of	ADP
bam-7218	713	40	muscle	muscle	NOUN
bam-7218	713	41	wasting	waste	VERB
bam-7218	713	42	.	.	PUNCT
bam-7218	714	1	this	this	DET
bam-7218	714	2	procedure	procedure	NOUN
bam-7218	714	3	could	could	AUX
bam-7218	714	4	be	be	AUX
bam-7218	714	5	widely	widely	ADV
bam-7218	714	6	applied	apply	VERB
bam-7218	714	7	to	to	ADP
bam-7218	714	8	other	other	ADJ
bam-7218	714	9	disease	disease	NOUN
bam-7218	714	10	models	model	NOUN
bam-7218	714	11	characterized	characterize	VERB
bam-7218	714	12	by	by	ADP
bam-7218	714	13	muscle	muscle	NOUN
bam-7218	714	14	wasting	waste	VERB
bam-7218	714	15	,	,	PUNCT
bam-7218	714	16	to	to	PART
bam-7218	714	17	assist	assist	VERB
bam-7218	714	18	drug	drug	NOUN
bam-7218	714	19	development	development	NOUN
bam-7218	714	20	and	and	CCONJ
bam-7218	714	21	search	search	NOUN
bam-7218	714	22	for	for	ADP
bam-7218	714	23	early	early	ADJ
bam-7218	714	24	biomarkers	biomarker	NOUN
bam-7218	714	25	of	of	ADP
bam-7218	714	26	muscle	muscle	NOUN
bam-7218	714	27	atrophy	atrophy	NOUN
bam-7218	714	28	.	.	PUNCT
bam-7218	715	1	#	#	SYM
bam-7218	715	2	equally	equally	ADV
bam-7218	715	3	contributing	contribute	VERB
bam-7218	715	4	authors	author	NOUN
bam-7218	715	5	.	.	PUNCT
bam-7218	716	1	7.3	7.3	NUM
bam-7218	716	2	musclin	musclin	NOUN
bam-7218	716	3	:	:	PUNCT
bam-7218	716	4	an	an	DET
bam-7218	716	5	exercise	exercise	NOUN
bam-7218	716	6	-	-	PUNCT
bam-7218	716	7	induced	induce	VERB
bam-7218	716	8	myokine	myokine	NOUN
bam-7218	716	9	useful	useful	ADJ
bam-7218	716	10	to	to	PART
bam-7218	716	11	contrast	contrast	VERB
bam-7218	716	12	muscle	muscle	NOUN
bam-7218	716	13	wasting	waste	VERB
bam-7218	716	14	during	during	ADP
bam-7218	716	15	cancer	cancer	NOUN
bam-7218	716	16	andrea	andrea	PROPN
bam-7218	716	17	david	david	PROPN
bam-7218	716	18	re	re	PROPN
bam-7218	716	19	cecconi	cecconi	PROPN
bam-7218	716	20	,	,	PUNCT
bam-7218	716	21	giulia	giulia	PROPN
bam-7218	716	22	benedetta	benedetta	PROPN
bam-7218	716	23	martinelli	martinelli	PROPN
bam-7218	716	24	,	,	PUNCT
bam-7218	716	25	sara	sara	PROPN
bam-7218	716	26	previdi	previdi	PROPN
bam-7218	716	27	,	,	PUNCT
bam-7218	716	28	sergio	sergio	PROPN
bam-7218	716	29	marchini	marchini	PROPN
bam-7218	716	30	,	,	PUNCT
bam-7218	716	31	luca	luca	PROPN
bam-7218	716	32	beltrame	beltrame	PROPN
bam-7218	716	33	,	,	PUNCT
bam-7218	716	34	rosanna	rosanna	NOUN
bam-7218	716	35	piccirillo	piccirillo	PROPN
bam-7218	716	36	oncology	oncology	NOUN
bam-7218	716	37	dept	dept	NOUN
bam-7218	716	38	,	,	PUNCT
bam-7218	716	39	irccs	irccs	NOUN
bam-7218	716	40	-	-	PUNCT
bam-7218	716	41	mario	mario	NOUN
bam-7218	716	42	negri	negri	PROPN
bam-7218	716	43	research	research	PROPN
bam-7218	716	44	institute	institute	PROPN
bam-7218	716	45	for	for	ADP
bam-7218	716	46	pharmacological	pharmacological	ADJ
bam-7218	716	47	research	research	NOUN
bam-7218	716	48	,	,	PUNCT
bam-7218	716	49	milan	milan	PROPN
bam-7218	716	50	,	,	PUNCT
bam-7218	716	51	italy	italy	PROPN
bam-7218	716	52	.	.	PUNCT
bam-7218	717	1	e	e	X
bam-7218	717	2	-	-	NOUN
bam-7218	717	3	mail	mail	NOUN
bam-7218	717	4	:	:	PUNCT
bam-7218	717	5	andrea.rececconi@marionegri.it	andrea.rececconi@marionegri.it	PROPN
bam-7218	717	6	physical	physical	ADJ
bam-7218	717	7	activity	activity	NOUN
bam-7218	717	8	extends	extend	VERB
bam-7218	717	9	life	life	NOUN
bam-7218	717	10	span	span	NOUN
bam-7218	717	11	of	of	ADP
bam-7218	717	12	patients	patient	NOUN
bam-7218	717	13	affected	affect	VERB
bam-7218	717	14	by	by	ADP
bam-7218	717	15	certain	certain	ADJ
bam-7218	717	16	types	type	NOUN
bam-7218	717	17	of	of	ADP
bam-7218	717	18	cancer	cancer	NOUN
bam-7218	717	19	,	,	PUNCT
bam-7218	717	20	also	also	ADV
bam-7218	717	21	by	by	ADP
bam-7218	717	22	contrasting	contrast	VERB
bam-7218	717	23	the	the	DET
bam-7218	717	24	associated	associated	ADJ
bam-7218	717	25	muscle	muscle	NOUN
bam-7218	717	26	wasting	waste	VERB
bam-7218	717	27	(	(	PUNCT
bam-7218	717	28	i.e.	i.e.	X
bam-7218	717	29	cachexia	cachexia	NOUN
bam-7218	717	30	)	)	PUNCT
bam-7218	717	31	.	.	PUNCT
bam-7218	718	1	the	the	DET
bam-7218	718	2	most	most	ADV
bam-7218	718	3	effective	effective	ADJ
bam-7218	718	4	type	type	NOUN
bam-7218	718	5	of	of	ADP
bam-7218	718	6	physical	physical	ADJ
bam-7218	718	7	activity	activity	NOUN
bam-7218	718	8	against	against	ADP
bam-7218	718	9	muscle	muscle	NOUN
bam-7218	718	10	wasting	waste	VERB
bam-7218	718	11	during	during	ADP
bam-7218	718	12	cancer	cancer	NOUN
bam-7218	718	13	seems	seem	VERB
bam-7218	718	14	to	to	PART
bam-7218	718	15	be	be	AUX
bam-7218	718	16	aerobic	aerobic	ADJ
bam-7218	718	17	exercise	exercise	NOUN
bam-7218	718	18	.	.	PUNCT
bam-7218	719	1	so	so	ADV
bam-7218	719	2	,	,	PUNCT
bam-7218	719	3	we	we	PRON
bam-7218	719	4	asked	ask	VERB
bam-7218	719	5	whether	whether	SCONJ
bam-7218	719	6	it	it	PRON
bam-7218	719	7	promotes	promote	VERB
bam-7218	719	8	secretion	secretion	NOUN
bam-7218	719	9	of	of	ADP
bam-7218	719	10	proteins	protein	NOUN
bam-7218	719	11	by	by	ADP
bam-7218	719	12	muscles	muscle	NOUN
bam-7218	719	13	(	(	PUNCT
bam-7218	719	14	i.e.	i.e.	X
bam-7218	719	15	myokines	myokine	NOUN
bam-7218	719	16	)	)	PUNCT
bam-7218	719	17	that	that	PRON
bam-7218	719	18	may	may	AUX
bam-7218	719	19	contrast	contrast	VERB
bam-7218	719	20	cancer	cancer	NOUN
bam-7218	719	21	cachexia	cachexia	NOUN
bam-7218	719	22	.	.	PUNCT
bam-7218	720	1	to	to	PART
bam-7218	720	2	mimic	mimic	VERB
bam-7218	720	3	aerobic	aerobic	ADJ
bam-7218	720	4	exercise	exercise	NOUN
bam-7218	720	5	,	,	PUNCT
bam-7218	720	6	we	we	PRON
bam-7218	720	7	infected	infect	VERB
bam-7218	720	8	c2c12	c2c12	PROPN
bam-7218	720	9	myotubes	myotube	NOUN
bam-7218	720	10	with	with	ADP
bam-7218	720	11	pgc1α	pgc1α	NOUN
bam-7218	720	12	-	-	PUNCT
bam-7218	720	13	expressing	express	VERB
bam-7218	720	14	adenoviruses	adenovirus	NOUN
bam-7218	720	15	,	,	PUNCT
bam-7218	720	16	because	because	SCONJ
bam-7218	720	17	pgc1α	pgc1α	PROPN
bam-7218	720	18	is	be	AUX
bam-7218	720	19	the	the	DET
bam-7218	720	20	main	main	ADJ
bam-7218	720	21	transcriptional	transcriptional	ADJ
bam-7218	720	22	coactivator	coactivator	NOUN
bam-7218	720	23	involved	involve	VERB
bam-7218	720	24	in	in	ADP
bam-7218	720	25	muscle	muscle	NOUN
bam-7218	720	26	adaptation	adaptation	NOUN
bam-7218	720	27	during	during	ADP
bam-7218	720	28	aerobic	aerobic	ADJ
bam-7218	720	29	exercise	exercise	NOUN
bam-7218	720	30	.	.	PUNCT
bam-7218	721	1	our	our	PRON
bam-7218	721	2	microarray	microarray	NOUN
bam-7218	721	3	analysis	analysis	NOUN
bam-7218	721	4	showed	show	VERB
bam-7218	721	5	musclin	musclin	NOUN
bam-7218	721	6	as	as	ADP
bam-7218	721	7	a	a	DET
bam-7218	721	8	pgc1αinduced	pgc1αinduced	PROPN
bam-7218	721	9	myokine	myokine	NOUN
bam-7218	721	10	.	.	PUNCT
bam-7218	722	1	we	we	PRON
bam-7218	722	2	further	far	ADV
bam-7218	722	3	immunoprecipitated	immunoprecipitate	VERB
bam-7218	722	4	it	it	PRON
bam-7218	722	5	only	only	ADV
bam-7218	722	6	from	from	ADP
bam-7218	722	7	supernatants	supernatant	NOUN
bam-7218	722	8	of	of	ADP
bam-7218	722	9	pgc1α	pgc1α	PROPN
bam-7218	722	10	expressing	express	VERB
bam-7218	722	11	-	-	PUNCT
bam-7218	722	12	myotubes	myotube	NOUN
bam-7218	722	13	.	.	PUNCT
bam-7218	723	1	by	by	ADP
bam-7218	723	2	q	q	NOUN
bam-7218	723	3	-	-	PUNCT
bam-7218	723	4	pcr	pcr	ADJ
bam-7218	723	5	,	,	PUNCT
bam-7218	723	6	we	we	PRON
bam-7218	723	7	found	find	VERB
bam-7218	723	8	musclin	musclin	PROPN
bam-7218	723	9	expression	expression	NOUN
bam-7218	723	10	unchanged	unchanged	ADJ
bam-7218	723	11	in	in	ADP
bam-7218	723	12	myotubes	myotube	NOUN
bam-7218	723	13	hypertrophying	hypertrophy	VERB
bam-7218	723	14	because	because	SCONJ
bam-7218	723	15	of	of	ADP
bam-7218	723	16	activated	activate	VERB
bam-7218	723	17	akt	akt	NOUN
bam-7218	723	18	(	(	PUNCT
bam-7218	723	19	to	to	PART
bam-7218	723	20	mimic	mimic	VERB
bam-7218	723	21	anaerobic	anaerobic	NOUN
bam-7218	723	22	exercise	exercise	NOUN
bam-7218	723	23	)	)	PUNCT
bam-7218	723	24	.	.	PUNCT
bam-7218	724	1	among	among	ADP
bam-7218	724	2	other	other	ADJ
bam-7218	724	3	pgc1αinduced	pgc1αinduced	PROPN
bam-7218	724	4	myokines	myokine	NOUN
bam-7218	724	5	,	,	PUNCT
bam-7218	724	6	we	we	PRON
bam-7218	724	7	found	find	VERB
bam-7218	724	8	only	only	ADV
bam-7218	724	9	musclin	musclin	PROPN
bam-7218	724	10	strongly	strongly	ADV
bam-7218	724	11	downregulated	downregulate	VERB
bam-7218	724	12	in	in	ADP
bam-7218	724	13	cachectic	cachectic	ADJ
bam-7218	724	14	muscles	muscle	NOUN
bam-7218	724	15	and	and	CCONJ
bam-7218	724	16	plasma	plasma	NOUN
bam-7218	724	17	of	of	ADP
bam-7218	724	18	c26bearing	c26beare	VERB
bam-7218	724	19	mice	mouse	NOUN
bam-7218	724	20	even	even	ADV
bam-7218	724	21	at	at	ADP
bam-7218	724	22	times	time	NOUN
bam-7218	724	23	when	when	SCONJ
bam-7218	724	24	their	their	PRON
bam-7218	724	25	body	body	NOUN
bam-7218	724	26	weights	weight	NOUN
bam-7218	724	27	were	be	AUX
bam-7218	724	28	not	not	PART
bam-7218	724	29	lost	lose	VERB
bam-7218	724	30	yet	yet	ADV
bam-7218	724	31	.	.	PUNCT
bam-7218	725	1	thus	thus	ADV
bam-7218	725	2	,	,	PUNCT
bam-7218	725	3	we	we	PRON
bam-7218	725	4	electroporated	electroporate	VERB
bam-7218	725	5	tibialis	tibialis	PROPN
bam-7218	725	6	anterior	anterior	NOUN
bam-7218	725	7	(	(	PUNCT
bam-7218	725	8	ta	ta	NOUN
bam-7218	725	9	)	)	PUNCT
bam-7218	725	10	of	of	ADP
bam-7218	725	11	c26	c26	NOUN
bam-7218	725	12	-	-	PUNCT
bam-7218	725	13	bearing	bear	VERB
bam-7218	725	14	mice	mouse	NOUN
bam-7218	725	15	with	with	ADP
bam-7218	725	16	musclinencoding	musclinencode	VERB
bam-7218	725	17	plasmids	plasmid	NOUN
bam-7218	725	18	and	and	CCONJ
bam-7218	725	19	found	find	VERB
bam-7218	725	20	musclin	musclin	NOUN
bam-7218	725	21	to	to	PART
bam-7218	725	22	preserve	preserve	VERB
bam-7218	725	23	fiber	fiber	NOUN
bam-7218	725	24	area	area	NOUN
bam-7218	725	25	.	.	PUNCT
bam-7218	726	1	dexamethazone	dexamethazone	NOUN
bam-7218	726	2	-	-	PUNCT
bam-7218	726	3	treated	treat	VERB
bam-7218	726	4	myotubes	myotube	NOUN
bam-7218	726	5	or	or	CCONJ
bam-7218	726	6	foxo3expressing	foxo3expresse	VERB
bam-7218	726	7	myotubes	myotube	NOUN
bam-7218	726	8	undergo	undergo	VERB
bam-7218	726	9	atrophy	atrophy	NOUN
bam-7218	726	10	as	as	SCONJ
bam-7218	726	11	measured	measure	VERB
bam-7218	726	12	by	by	ADP
bam-7218	726	13	increased	increase	VERB
bam-7218	726	14	rates	rate	NOUN
bam-7218	726	15	of	of	ADP
bam-7218	726	16	proteolysis	proteolysis	NOUN
bam-7218	726	17	and	and	CCONJ
bam-7218	726	18	murf1	murf1	ADJ
bam-7218	726	19	induction	induction	NOUN
bam-7218	726	20	.	.	PUNCT
bam-7218	727	1	unlike	unlike	ADP
bam-7218	727	2	gfp	gfp	PROPN
bam-7218	727	3	,	,	PUNCT
bam-7218	727	4	musclin	musclin	PROPN
bam-7218	727	5	was	be	AUX
bam-7218	727	6	able	able	ADJ
bam-7218	727	7	to	to	PART
bam-7218	727	8	contrast	contrast	VERB
bam-7218	727	9	the	the	DET
bam-7218	727	10	dexamethazone	dexamethazone	NOUN
bam-7218	727	11	induced	induced	ADJ
bam-7218	727	12	-	-	PUNCT
bam-7218	727	13	murf1	murf1	NOUN
bam-7218	727	14	expression	expression	NOUN
bam-7218	727	15	in	in	ADP
bam-7218	727	16	luciferase	luciferase	ADJ
bam-7218	727	17	assays	assay	NOUN
bam-7218	727	18	.	.	PUNCT
bam-7218	728	1	notably	notably	ADV
bam-7218	728	2	,	,	PUNCT
bam-7218	728	3	musclin	musclin	NOUN
bam-7218	728	4	-	-	PUNCT
bam-7218	728	5	containing	contain	VERB
bam-7218	728	6	supernatants	supernatant	NOUN
bam-7218	728	7	of	of	ADP
bam-7218	728	8	pgc1α	pgc1α	PROPN
bam-7218	728	9	expressing	express	VERB
bam-7218	728	10	-	-	PUNCT
bam-7218	728	11	myotubes	myotube	NOUN
bam-7218	728	12	restrained	restrain	VERB
bam-7218	728	13	the	the	DET
bam-7218	728	14	foxo3	foxo3	ADV
bam-7218	728	15	-	-	PUNCT
bam-7218	728	16	induced	induce	VERB
bam-7218	728	17	rates	rate	NOUN
bam-7218	728	18	of	of	ADP
bam-7218	728	19	long	long	ADV
bam-7218	728	20	-	-	PUNCT
bam-7218	728	21	lived	live	VERB
bam-7218	728	22	protein	protein	NOUN
bam-7218	728	23	degradation	degradation	NOUN
bam-7218	728	24	.	.	PUNCT
bam-7218	729	1	musclin	musclin	PROPN
bam-7218	729	2	is	be	AUX
bam-7218	729	3	a	a	DET
bam-7218	729	4	myokine	myokine	NOUN
bam-7218	729	5	induced	induce	VERB
bam-7218	729	6	specifically	specifically	ADV
bam-7218	729	7	by	by	ADP
bam-7218	729	8	pgc1α	pgc1α	PROPN
bam-7218	729	9	,	,	PUNCT
bam-7218	729	10	typically	typically	ADV
bam-7218	729	11	increased	increase	VERB
bam-7218	729	12	upon	upon	SCONJ
bam-7218	729	13	aerobic	aerobic	ADJ
bam-7218	729	14	exercise	exercise	NOUN
bam-7218	729	15	mailto:rosanna.piccirillo7@gmail.com	mailto:rosanna.piccirillo7@gmail.com	X
bam-7218	729	16	mailto:andrea.rececconi@marionegri.it	mailto:andrea.rececconi@marionegri.it	PROPN
bam-7218	729	17	14	14	NUM
bam-7218	729	18	th	th	NOUN
bam-7218	729	19	iiim	iiim	NOUN
bam-7218	729	20	meeting	meeting	NOUN
bam-7218	729	21	,	,	PUNCT
bam-7218	729	22	assisi	assisi	PROPN
bam-7218	729	23	,	,	PUNCT
bam-7218	729	24	italy	italy	PROPN
bam-7218	729	25	october	october	PROPN
bam-7218	729	26	12	12	NUM
bam-7218	729	27	-	-	SYM
bam-7218	729	28	15	15	NUM
bam-7218	729	29	2017	2017	NUM
bam-7218	729	30	eur	eur	PROPN
bam-7218	729	31	j	j	PROPN
bam-7218	729	32	transl	transl	PROPN
bam-7218	729	33	myol	myol	ADV
bam-7218	729	34	27	27	NUM
bam-7218	729	35	(	(	PUNCT
bam-7218	729	36	4	4	NUM
bam-7218	729	37	):	):	SYM
bam-7218	729	38	185	185	NUM
bam-7218	729	39	-	-	SYM
bam-7218	729	40	224	224	NUM
bam-7218	729	41	207	207	NUM
bam-7218	729	42	and	and	CCONJ
bam-7218	729	43	musclin	musclin	PROPN
bam-7218	729	44	overexpression	overexpression	NOUN
bam-7218	729	45	is	be	AUX
bam-7218	729	46	beneficial	beneficial	ADJ
bam-7218	729	47	against	against	ADP
bam-7218	729	48	muscle	muscle	NOUN
bam-7218	729	49	wasting	waste	VERB
bam-7218	729	50	during	during	ADP
bam-7218	729	51	c26	c26	NOUN
bam-7218	729	52	growth	growth	NOUN
bam-7218	729	53	or	or	CCONJ
bam-7218	729	54	in	in	ADP
bam-7218	729	55	atrophying	atrophy	VERB
bam-7218	729	56	myotubes	myotube	NOUN
bam-7218	729	57	.	.	PUNCT
bam-7218	730	1	overall	overall	ADV
bam-7218	730	2	,	,	PUNCT
bam-7218	730	3	musclin	musclin	PROPN
bam-7218	730	4	would	would	AUX
bam-7218	730	5	be	be	AUX
bam-7218	730	6	a	a	DET
bam-7218	730	7	good	good	ADJ
bam-7218	730	8	drug	drug	NOUN
bam-7218	730	9	option	option	NOUN
bam-7218	730	10	for	for	ADP
bam-7218	730	11	cancer	cancer	NOUN
bam-7218	730	12	patients	patient	NOUN
bam-7218	730	13	that	that	PRON
bam-7218	730	14	can	can	AUX
bam-7218	730	15	not	not	PART
bam-7218	730	16	exercise	exercise	VERB
bam-7218	730	17	and	and	CCONJ
bam-7218	730	18	are	be	AUX
bam-7218	730	19	at	at	ADP
bam-7218	730	20	risk	risk	NOUN
bam-7218	730	21	of	of	ADP
bam-7218	730	22	developing	develop	VERB
bam-7218	730	23	cachexia	cachexia	NOUN
bam-7218	730	24	.	.	PUNCT
bam-7218	731	1	7.4	7.4	NUM
bam-7218	731	2	elderly	elderly	ADJ
bam-7218	731	3	human	human	ADJ
bam-7218	731	4	mesoangioblasts	mesoangioblast	NOUN
bam-7218	731	5	are	be	AUX
bam-7218	731	6	impaired	impair	VERB
bam-7218	731	7	in	in	ADP
bam-7218	731	8	proliferation	proliferation	NOUN
bam-7218	731	9	and	and	CCONJ
bam-7218	731	10	in	in	ADP
bam-7218	731	11	differentiation	differentiation	NOUN
bam-7218	731	12	potential	potential	ADJ
bam-7218	731	13	alessio	alessio	PROPN
bam-7218	731	14	rotini	rotini	NOUN
bam-7218	731	15	(	(	PUNCT
bam-7218	731	16	a	a	DET
bam-7218	731	17	,	,	PUNCT
bam-7218	731	18	b	b	NOUN
bam-7218	731	19	)	)	PUNCT
bam-7218	731	20	,	,	PUNCT
bam-7218	731	21	ester	ester	NOUN
bam-7218	731	22	martínez	martínez	PROPN
bam-7218	731	23	-	-	PUNCT
bam-7218	731	24	sarrà	sarrà	PROPN
bam-7218	731	25	(	(	PUNCT
bam-7218	731	26	a	a	X
bam-7218	731	27	)	)	PUNCT
bam-7218	731	28	,	,	PUNCT
bam-7218	731	29	robin	robin	PROPN
bam-7218	731	30	duelen	duelen	PROPN
bam-7218	731	31	(	(	PUNCT
bam-7218	731	32	a	a	X
bam-7218	731	33	)	)	PUNCT
bam-7218	731	34	,	,	PUNCT
bam-7218	731	35	domiziana	domiziana	NOUN
bam-7218	731	36	costamagna	costamagna	NOUN
bam-7218	731	37	(	(	PUNCT
bam-7218	731	38	a	a	DET
bam-7218	731	39	,	,	PUNCT
bam-7218	731	40	c	c	NOUN
bam-7218	731	41	)	)	PUNCT
bam-7218	731	42	,	,	PUNCT
bam-7218	731	43	ester	ester	NOUN
bam-7218	731	44	sara	sara	PROPN
bam-7218	731	45	di	di	PROPN
bam-7218	731	46	filippo	filippo	PROPN
bam-7218	731	47	(	(	PUNCT
bam-7218	731	48	b	b	NOUN
bam-7218	731	49	)	)	PUNCT
bam-7218	731	50	,	,	PUNCT
bam-7218	731	51	stefania	stefania	NOUN
bam-7218	731	52	fulle	fulle	ADV
bam-7218	731	53	(	(	PUNCT
bam-7218	731	54	b	b	NOUN
bam-7218	731	55	)	)	PUNCT
bam-7218	731	56	,	,	PUNCT
bam-7218	731	57	maurilio	maurilio	NOUN
bam-7218	731	58	sampaolesi	sampaolesi	NOUN
bam-7218	731	59	(	(	PUNCT
bam-7218	731	60	a	a	DET
bam-7218	731	61	,	,	PUNCT
bam-7218	731	62	c	c	NOUN
bam-7218	731	63	)	)	PUNCT
bam-7218	731	64	(	(	PUNCT
bam-7218	731	65	a	a	X
bam-7218	731	66	)	)	PUNCT
bam-7218	731	67	translational	translational	ADJ
bam-7218	731	68	cardiomyology	cardiomyology	NOUN
bam-7218	731	69	laboratory	laboratory	NOUN
bam-7218	731	70	,	,	PUNCT
bam-7218	731	71	stem	stem	NOUN
bam-7218	731	72	cell	cell	NOUN
bam-7218	731	73	biology	biology	NOUN
bam-7218	731	74	and	and	CCONJ
bam-7218	731	75	embryology	embryology	NOUN
bam-7218	731	76	unit	unit	NOUN
bam-7218	731	77	,	,	PUNCT
bam-7218	731	78	dept	dept	NOUN
bam-7218	731	79	of	of	ADP
bam-7218	731	80	development	development	NOUN
bam-7218	731	81	and	and	CCONJ
bam-7218	731	82	regeneration	regeneration	NOUN
bam-7218	731	83	,	,	PUNCT
bam-7218	731	84	ku	ku	PROPN
bam-7218	731	85	leuven	leuven	PROPN
bam-7218	731	86	,	,	PUNCT
bam-7218	731	87	leuven	leuven	PROPN
bam-7218	731	88	,	,	PUNCT
bam-7218	731	89	belgium	belgium	NOUN
bam-7218	731	90	;	;	PUNCT
bam-7218	731	91	
	
	SPACE
bam-7218	731	92	(	(	PUNCT
bam-7218	731	93	b	b	NOUN
bam-7218	731	94	)	)	PUNCT
bam-7218	731	95	dept	dept	NOUN
bam-7218	731	96	of	of	ADP
bam-7218	731	97	neuroscience	neuroscience	NOUN
bam-7218	731	98	,	,	PUNCT
bam-7218	731	99	imaging	imaging	NOUN
bam-7218	731	100	and	and	CCONJ
bam-7218	731	101	clinical	clinical	ADJ
bam-7218	731	102	sciences	science	NOUN
bam-7218	731	103	,	,	PUNCT
bam-7218	731	104	university	university	NOUN
bam-7218	731	105	"	"	PUNCT
bam-7218	731	106	g.	g.	PROPN
bam-7218	731	107	d'annunzio	d'annunzio	PROPN
bam-7218	731	108	"	"	PUNCT
bam-7218	731	109	chieti	chieti	PROPN
bam-7218	731	110	-	-	PUNCT
bam-7218	731	111	pescara	pescara	PROPN
bam-7218	731	112	,	,	PUNCT
bam-7218	731	113	italy	italy	PROPN
bam-7218	731	114	;	;	PUNCT
bam-7218	731	115	interuniversity	interuniversity	NOUN
bam-7218	731	116	institute	institute	PROPN
bam-7218	731	117	of	of	ADP
bam-7218	731	118	myology	myology	NOUN
bam-7218	731	119	,	,	PUNCT
bam-7218	731	120	chieti	chieti	PROPN
bam-7218	731	121	,	,	PUNCT
bam-7218	731	122	italy	italy	PROPN
bam-7218	731	123	;	;	PUNCT
bam-7218	731	124	
	
	SPACE
bam-7218	731	125	(	(	PUNCT
bam-7218	731	126	c	c	NOUN
bam-7218	731	127	)	)	PUNCT
bam-7218	731	128	division	division	NOUN
bam-7218	731	129	of	of	ADP
bam-7218	731	130	human	human	ADJ
bam-7218	731	131	anatomy	anatomy	NOUN
bam-7218	731	132	,	,	PUNCT
bam-7218	731	133	dept	dept	NOUN
bam-7218	731	134	of	of	ADP
bam-7218	731	135	public	public	ADJ
bam-7218	731	136	health	health	NOUN
bam-7218	731	137	,	,	PUNCT
bam-7218	731	138	experimental	experimental	ADJ
bam-7218	731	139	and	and	CCONJ
bam-7218	731	140	forensic	forensic	ADJ
bam-7218	731	141	medicine	medicine	NOUN
bam-7218	731	142	,	,	PUNCT
bam-7218	731	143	university	university	NOUN
bam-7218	731	144	of	of	ADP
bam-7218	731	145	pavia	pavia	PROPN
bam-7218	731	146	,	,	PUNCT
bam-7218	731	147	pavia	pavia	PROPN
bam-7218	731	148	,	,	PUNCT
bam-7218	731	149	italy	italy	PROPN
bam-7218	731	150	.	.	PUNCT
bam-7218	732	1	e	e	X
bam-7218	732	2	-	-	NOUN
bam-7218	732	3	mail	mail	NOUN
bam-7218	732	4	:	:	PUNCT
bam-7218	732	5	alessio.rotini@gmail.com	alessio.rotini@gmail.com	X
bam-7218	732	6	muscle	muscle	NOUN
bam-7218	732	7	wasting	waste	VERB
bam-7218	732	8	is	be	AUX
bam-7218	732	9	responsible	responsible	ADJ
bam-7218	732	10	for	for	ADP
bam-7218	732	11	severe	severe	ADJ
bam-7218	732	12	debilitating	debilitate	VERB
bam-7218	732	13	weakness	weakness	NOUN
bam-7218	732	14	and	and	CCONJ
bam-7218	732	15	it	it	PRON
bam-7218	732	16	is	be	AUX
bam-7218	732	17	well	well	ADV
bam-7218	732	18	known	know	VERB
bam-7218	732	19	as	as	ADP
bam-7218	732	20	sarcopenia	sarcopenia	NOUN
bam-7218	732	21	when	when	SCONJ
bam-7218	732	22	it	it	PRON
bam-7218	732	23	occurs	occur	VERB
bam-7218	732	24	in	in	ADP
bam-7218	732	25	aged	aged	ADJ
bam-7218	732	26	people	people	NOUN
bam-7218	732	27	causing	cause	VERB
bam-7218	732	28	loss	loss	NOUN
bam-7218	732	29	of	of	ADP
bam-7218	732	30	muscle	muscle	NOUN
bam-7218	732	31	mass	mass	PROPN
bam-7218	732	32	,	,	PUNCT
bam-7218	732	33	strength	strength	NOUN
bam-7218	732	34	and	and	CCONJ
bam-7218	732	35	function	function	NOUN
bam-7218	732	36	[	[	X
bam-7218	732	37	1	1	NUM
bam-7218	732	38	]	]	PUNCT
bam-7218	732	39	.	.	PUNCT
bam-7218	733	1	recent	recent	ADJ
bam-7218	733	2	literature	literature	NOUN
bam-7218	733	3	revealed	reveal	VERB
bam-7218	733	4	that	that	SCONJ
bam-7218	733	5	human	human	ADJ
bam-7218	733	6	satellite	satellite	NOUN
bam-7218	733	7	cells	cell	NOUN
bam-7218	733	8	are	be	AUX
bam-7218	733	9	impaired	impair	VERB
bam-7218	733	10	in	in	ADP
bam-7218	733	11	elderly	elderly	ADJ
bam-7218	733	12	subjects	subject	NOUN
bam-7218	733	13	[	[	X
bam-7218	733	14	2	2	NUM
bam-7218	733	15	]	]	PUNCT
bam-7218	733	16	,	,	PUNCT
bam-7218	733	17	however	however	ADV
bam-7218	733	18	,	,	PUNCT
bam-7218	733	19	how	how	SCONJ
bam-7218	733	20	interstitial	interstitial	ADJ
bam-7218	733	21	muscle	muscle	NOUN
bam-7218	733	22	cells	cell	NOUN
bam-7218	733	23	affect	affect	VERB
bam-7218	733	24	tissue	tissue	NOUN
bam-7218	733	25	regeneration	regeneration	NOUN
bam-7218	733	26	and	and	CCONJ
bam-7218	733	27	fatty	fatty	NOUN
bam-7218	733	28	deposition	deposition	NOUN
bam-7218	733	29	upon	upon	SCONJ
bam-7218	733	30	ageing	ageing	NOUN
bam-7218	733	31	has	have	AUX
bam-7218	733	32	not	not	PART
bam-7218	733	33	yet	yet	ADV
bam-7218	733	34	been	be	AUX
bam-7218	733	35	elucidated	elucidate	VERB
bam-7218	733	36	.	.	PUNCT
bam-7218	734	1	firstly	firstly	ADV
bam-7218	734	2	,	,	PUNCT
bam-7218	734	3	we	we	PRON
bam-7218	734	4	isolated	isolate	VERB
bam-7218	734	5	the	the	DET
bam-7218	734	6	non	non	ADJ
bam-7218	734	7	-	-	ADJ
bam-7218	734	8	satellite	satellite	ADJ
bam-7218	734	9	cell	cell	NOUN
bam-7218	734	10	fraction	fraction	NOUN
bam-7218	734	11	from	from	ADP
bam-7218	734	12	human	human	ADJ
bam-7218	734	13	muscle	muscle	NOUN
bam-7218	734	14	biopsies	biopsy	NOUN
bam-7218	734	15	of	of	ADP
bam-7218	734	16	young	young	ADJ
bam-7218	734	17	and	and	CCONJ
bam-7218	734	18	elderly	elderly	ADJ
bam-7218	734	19	subjects	subject	NOUN
bam-7218	734	20	,	,	PUNCT
bam-7218	734	21	referred	refer	VERB
bam-7218	734	22	here	here	ADV
bam-7218	734	23	as	as	ADP
bam-7218	734	24	cd56interstitial	cd56interstitial	ADJ
bam-7218	734	25	cells	cell	NOUN
bam-7218	734	26	.	.	PUNCT
bam-7218	735	1	the	the	DET
bam-7218	735	2	elderly	elderly	ADJ
bam-7218	735	3	cd56interstitial	cd56interstitial	ADJ
bam-7218	735	4	cells	cell	NOUN
bam-7218	735	5	showed	show	VERB
bam-7218	735	6	a	a	DET
bam-7218	735	7	larger	large	ADJ
bam-7218	735	8	number	number	NOUN
bam-7218	735	9	of	of	ADP
bam-7218	735	10	cd15	cd15	PROPN
bam-7218	735	11	+	+	CCONJ
bam-7218	735	12	and	and	CCONJ
bam-7218	735	13	pdgfrα+	pdgfrα+	VERB
bam-7218	735	14	cells	cell	NOUN
bam-7218	735	15	in	in	ADP
bam-7218	735	16	comparison	comparison	NOUN
bam-7218	735	17	with	with	ADP
bam-7218	735	18	young	young	ADJ
bam-7218	735	19	interstitial	interstitial	ADJ
bam-7218	735	20	cells	cell	NOUN
bam-7218	735	21	.	.	PUNCT
bam-7218	736	1	moreover	moreover	ADV
bam-7218	736	2	,	,	PUNCT
bam-7218	736	3	cd56-/alp+	cd56-/alp+	PROPN
bam-7218	736	4	cells	cell	NOUN
bam-7218	736	5	were	be	AUX
bam-7218	736	6	the	the	DET
bam-7218	736	7	most	most	ADV
bam-7218	736	8	abundant	abundant	ADJ
bam-7218	736	9	plastic	plastic	ADJ
bam-7218	736	10	cell	cell	NOUN
bam-7218	736	11	population	population	NOUN
bam-7218	736	12	able	able	ADJ
bam-7218	736	13	to	to	PART
bam-7218	736	14	differentiate	differentiate	VERB
bam-7218	736	15	into	into	ADP
bam-7218	736	16	smooth	smooth	ADJ
bam-7218	736	17	muscle	muscle	NOUN
bam-7218	736	18	cells	cell	NOUN
bam-7218	736	19	and	and	CCONJ
bam-7218	736	20	adipocytes	adipocyte	NOUN
bam-7218	736	21	,	,	PUNCT
bam-7218	736	22	and	and	CCONJ
bam-7218	736	23	the	the	DET
bam-7218	736	24	unique	unique	ADJ
bam-7218	736	25	interstitial	interstitial	ADJ
bam-7218	736	26	population	population	NOUN
bam-7218	736	27	with	with	ADP
bam-7218	736	28	myogenic	myogenic	ADJ
bam-7218	736	29	differentiation	differentiation	NOUN
bam-7218	736	30	potential	potential	NOUN
bam-7218	736	31	.	.	PUNCT
bam-7218	737	1	they	they	PRON
bam-7218	737	2	expressed	express	VERB
bam-7218	737	3	pericyte	pericyte	NOUN
bam-7218	737	4	markers	marker	NOUN
bam-7218	737	5	including	include	VERB
bam-7218	737	6	ng2	ng2	PROPN
bam-7218	737	7	,	,	PUNCT
bam-7218	737	8	αsma	αsma	NOUN
bam-7218	737	9	and	and	CCONJ
bam-7218	737	10	pdgfr	pdgfr	ADJ
bam-7218	737	11	-	-	PUNCT
bam-7218	737	12	β	β	NOUN
bam-7218	737	13	and	and	CCONJ
bam-7218	737	14	were	be	AUX
bam-7218	737	15	referred	refer	VERB
bam-7218	737	16	as	as	ADP
bam-7218	737	17	mesoangioblasts	mesoangioblast	NOUN
bam-7218	737	18	(	(	PUNCT
bam-7218	737	19	mabs	mab	NOUN
bam-7218	737	20	)	)	PUNCT
bam-7218	737	21	,	,	PUNCT
bam-7218	737	22	vessel	vessel	NOUN
bam-7218	737	23	-	-	PUNCT
bam-7218	737	24	associated	associate	VERB
bam-7218	737	25	stem	stem	NOUN
bam-7218	737	26	cells	cell	NOUN
bam-7218	737	27	.	.	PUNCT
bam-7218	738	1	interestingly	interestingly	ADV
bam-7218	738	2	,	,	PUNCT
bam-7218	738	3	elderly	elderly	ADJ
bam-7218	738	4	mabs	mab	NOUN
bam-7218	738	5	displayed	display	VERB
bam-7218	738	6	a	a	DET
bam-7218	738	7	dramatic	dramatic	ADJ
bam-7218	738	8	impairment	impairment	NOUN
bam-7218	738	9	in	in	ADP
bam-7218	738	10	the	the	DET
bam-7218	738	11	myogenic	myogenic	ADJ
bam-7218	738	12	differentiation	differentiation	NOUN
bam-7218	738	13	ability	ability	NOUN
bam-7218	738	14	in	in	ADP
bam-7218	738	15	vitro	vitro	X
bam-7218	738	16	and	and	CCONJ
bam-7218	738	17	after	after	ADP
bam-7218	738	18	transplantation	transplantation	NOUN
bam-7218	738	19	in	in	ADP
bam-7218	738	20	immunodeficient	immunodeficient	NOUN
bam-7218	738	21	dystrophic	dystrophic	ADJ
bam-7218	738	22	mice	mouse	NOUN
bam-7218	738	23	(	(	PUNCT
bam-7218	738	24	sgcb	sgcb	NOUN
bam-7218	738	25	-	-	PUNCT
bam-7218	738	26	null	null	NOUN
bam-7218	738	27	rag2	rag2	PROPN
bam-7218	738	28	-	-	PUNCT
bam-7218	738	29	null	null	PROPN
bam-7218	738	30	γc	γc	PROPN
bam-7218	738	31	-	-	ADJ
bam-7218	738	32	null	null	ADJ
bam-7218	738	33	mice	mouse	NOUN
bam-7218	738	34	)	)	PUNCT
bam-7218	738	35	.	.	PUNCT
bam-7218	739	1	in	in	ADP
bam-7218	739	2	addition	addition	NOUN
bam-7218	739	3	,	,	PUNCT
bam-7218	739	4	elderly	elderly	ADJ
bam-7218	739	5	mabs	mab	NOUN
bam-7218	739	6	proliferated	proliferate	VERB
bam-7218	739	7	less	less	ADV
bam-7218	739	8	,	,	PUNCT
bam-7218	739	9	but	but	CCONJ
bam-7218	739	10	yet	yet	ADV
bam-7218	739	11	retained	retain	VERB
bam-7218	739	12	other	other	ADJ
bam-7218	739	13	multilineage	multilineage	NOUN
bam-7218	739	14	capabilities	capability	NOUN
bam-7218	739	15	.	.	PUNCT
bam-7218	740	1	taken	take	VERB
bam-7218	740	2	together	together	ADV
bam-7218	740	3	,	,	PUNCT
bam-7218	740	4	our	our	PRON
bam-7218	740	5	results	result	NOUN
bam-7218	740	6	suggest	suggest	VERB
bam-7218	740	7	that	that	SCONJ
bam-7218	740	8	the	the	DET
bam-7218	740	9	cd56cell	cd56cell	PROPN
bam-7218	740	10	fraction	fraction	NOUN
bam-7218	740	11	is	be	AUX
bam-7218	740	12	modulated	modulate	VERB
bam-7218	740	13	in	in	ADP
bam-7218	740	14	skeletal	skeletal	ADJ
bam-7218	740	15	muscle	muscle	NOUN
bam-7218	740	16	during	during	ADP
bam-7218	740	17	ageing	age	VERB
bam-7218	740	18	,	,	PUNCT
bam-7218	740	19	it	it	PRON
bam-7218	740	20	is	be	AUX
bam-7218	740	21	possibly	possibly	ADV
bam-7218	740	22	involved	involve	VERB
bam-7218	740	23	in	in	ADP
bam-7218	740	24	the	the	DET
bam-7218	740	25	fibroadipogenic	fibroadipogenic	ADJ
bam-7218	740	26	deposition	deposition	NOUN
bam-7218	740	27	and	and	CCONJ
bam-7218	740	28	could	could	AUX
bam-7218	740	29	represent	represent	VERB
bam-7218	740	30	a	a	DET
bam-7218	740	31	feasible	feasible	ADJ
bam-7218	740	32	target	target	NOUN
bam-7218	740	33	for	for	ADP
bam-7218	740	34	future	future	ADJ
bam-7218	740	35	treatments	treatment	NOUN
bam-7218	740	36	aimed	aim	VERB
bam-7218	740	37	to	to	PART
bam-7218	740	38	reduce	reduce	VERB
bam-7218	740	39	muscle	muscle	NOUN
bam-7218	740	40	loss	loss	NOUN
bam-7218	740	41	and	and	CCONJ
bam-7218	740	42	wasting	wasting	NOUN
bam-7218	740	43	.	.	PUNCT
bam-7218	741	1	references	reference	NOUN
bam-7218	741	2	:	:	PUNCT
bam-7218	741	3	
	
	SPACE
bam-7218	741	4	1	1	X
bam-7218	741	5	)	)	PUNCT
bam-7218	741	6	delbono	delbono	NOUN
bam-7218	741	7	o	o	NOUN
bam-7218	741	8	(	(	PUNCT
bam-7218	741	9	2011	2011	NUM
bam-7218	741	10	)	)	PUNCT
bam-7218	741	11	.	.	PUNCT
bam-7218	742	1	expression	expression	NOUN
bam-7218	742	2	and	and	CCONJ
bam-7218	742	3	regulation	regulation	NOUN
bam-7218	742	4	of	of	ADP
bam-7218	742	5	excitation	excitation	NOUN
bam-7218	742	6	-	-	PUNCT
bam-7218	742	7	contraction	contraction	NOUN
bam-7218	742	8	coupling	couple	VERB
bam-7218	742	9	proteins	protein	NOUN
bam-7218	742	10	in	in	ADP
bam-7218	742	11	aging	age	VERB
bam-7218	742	12	skeletal	skeletal	ADJ
bam-7218	742	13	muscle	muscle	NOUN
bam-7218	742	14	.	.	PUNCT
bam-7218	743	1	current	current	ADJ
bam-7218	743	2	aging	age	VERB
bam-7218	743	3	science	science	NOUN
bam-7218	743	4	.	.	PUNCT
bam-7218	744	1	4	4	NUM
bam-7218	744	2	,	,	PUNCT
bam-7218	744	3	248259	248259	NUM
bam-7218	744	4	.	.	PUNCT
bam-7218	745	1	2	2	X
bam-7218	745	2	)	)	PUNCT
bam-7218	745	3	pietrangelo	pietrangelo	PROPN
bam-7218	745	4	t	t	PROPN
bam-7218	745	5	,	,	PUNCT
bam-7218	745	6	di	di	X
bam-7218	745	7	filippo	filippo	PROPN
bam-7218	745	8	es	es	PROPN
bam-7218	745	9	,	,	PUNCT
bam-7218	745	10	doria	doria	PROPN
bam-7218	745	11	c	c	PROPN
bam-7218	745	12	,	,	PUNCT
bam-7218	745	13	rotini	rotini	X
bam-7218	745	14	a	a	X
bam-7218	745	15	,	,	PUNCT
bam-7218	745	16	fanò	fanò	PROPN
bam-7218	745	17	-	-	PUNCT
bam-7218	745	18	ilicic	ilicic	PROPN
bam-7218	745	19	g	g	PROPN
bam-7218	745	20	,	,	PUNCT
bam-7218	745	21	fulle	fulle	NOUN
bam-7218	745	22	s	s	X
bam-7218	745	23	(	(	PUNCT
bam-7218	745	24	2015	2015	NUM
bam-7218	745	25	)	)	PUNCT
bam-7218	745	26	.	.	PUNCT
bam-7218	746	1	low	low	ADJ
bam-7218	746	2	intensity	intensity	NOUN
bam-7218	746	3	exercise	exercise	NOUN
bam-7218	746	4	training	training	NOUN
bam-7218	746	5	improves	improve	VERB
bam-7218	746	6	skeletal	skeletal	ADJ
bam-7218	746	7	muscle	muscle	NOUN
bam-7218	746	8	regeneration	regeneration	NOUN
bam-7218	746	9	potential	potential	NOUN
bam-7218	746	10	.	.	PUNCT
bam-7218	747	1	frontiers	frontier	NOUN
bam-7218	747	2	in	in	ADP
bam-7218	747	3	physiology	physiology	NOUN
bam-7218	747	4	6:399	6:399	NOUN
bam-7218	747	5	.	.	PUNCT
bam-7218	748	1	7.5	7.5	NUM
bam-7218	748	2	role	role	NOUN
bam-7218	748	3	of	of	ADP
bam-7218	748	4	mical2	mical2	NOUN
bam-7218	748	5	in	in	ADP
bam-7218	748	6	adult	adult	NOUN
bam-7218	748	7	myogenic	myogenic	ADJ
bam-7218	748	8	differentiation	differentiation	NOUN
bam-7218	748	9	nefele	nefele	PROPN
bam-7218	748	10	giarratana	giarratana	NOUN
bam-7218	748	11	(	(	PUNCT
bam-7218	748	12	a	a	DET
bam-7218	748	13	,	,	PUNCT
bam-7218	748	14	b	b	NOUN
bam-7218	748	15	)	)	PUNCT
bam-7218	748	16	,	,	PUNCT
bam-7218	748	17	domiziana	domiziana	PROPN
bam-7218	748	18	costamagna	costamagna	NOUN
bam-7218	748	19	(	(	PUNCT
bam-7218	748	20	b	b	NOUN
bam-7218	748	21	,	,	PUNCT
bam-7218	748	22	c	c	NOUN
bam-7218	748	23	)	)	PUNCT
bam-7218	748	24	,	,	PUNCT
bam-7218	748	25	robin	robin	PROPN
bam-7218	748	26	duelen	duelen	PROPN
bam-7218	748	27	(	(	PUNCT
bam-7218	748	28	b	b	NOUN
bam-7218	748	29	)	)	PUNCT
bam-7218	748	30	,	,	PUNCT
bam-7218	748	31	stefania	stefania	NOUN
bam-7218	748	32	fulle	fulle	ADV
bam-7218	748	33	(	(	PUNCT
bam-7218	748	34	a	a	NOUN
bam-7218	748	35	)	)	PUNCT
bam-7218	748	36	,	,	PUNCT
bam-7218	748	37	maurilio	maurilio	NOUN
bam-7218	748	38	sampaolesi	sampaolesi	NOUN
bam-7218	748	39	(	(	PUNCT
bam-7218	748	40	b	b	NOUN
bam-7218	748	41	,	,	PUNCT
bam-7218	748	42	c	c	NOUN
bam-7218	748	43	)	)	PUNCT
bam-7218	748	44	(	(	PUNCT
bam-7218	748	45	a	a	X
bam-7218	748	46	)	)	PUNCT
bam-7218	748	47	dept	dept	NOUN
bam-7218	748	48	of	of	ADP
bam-7218	748	49	neurosciences	neuroscience	NOUN
bam-7218	748	50	,	,	PUNCT
bam-7218	748	51	imaging	imaging	NOUN
bam-7218	748	52	and	and	CCONJ
bam-7218	748	53	clinical	clinical	ADJ
bam-7218	748	54	sciences	science	NOUN
bam-7218	748	55	,	,	PUNCT
bam-7218	748	56	università	università	PROPN
bam-7218	748	57	g.	g.	PROPN
bam-7218	748	58	d’annunzio	d’annunzio	PROPN
bam-7218	748	59	chieti	chieti	PROPN
bam-7218	748	60	italy	italy	PROPN
bam-7218	748	61	;	;	PUNCT
bam-7218	748	62	
	
	SPACE
bam-7218	748	63	(	(	PUNCT
bam-7218	748	64	b	b	NOUN
bam-7218	748	65	)	)	PUNCT
bam-7218	748	66	laboratory	laboratory	NOUN
bam-7218	748	67	of	of	ADP
bam-7218	748	68	translational	translational	ADJ
bam-7218	748	69	cardiomyology	cardiomyology	NOUN
bam-7218	748	70	,	,	PUNCT
bam-7218	748	71	dept	dept	NOUN
bam-7218	748	72	of	of	ADP
bam-7218	748	73	development	development	NOUN
bam-7218	748	74	and	and	CCONJ
bam-7218	748	75	regeneration	regeneration	NOUN
bam-7218	748	76	,	,	PUNCT
bam-7218	748	77	
	
	SPACE
bam-7218	748	78	ku	ku	PROPN
bam-7218	748	79	leuven	leuven	PROPN
bam-7218	748	80	belgium	belgium	PROPN
bam-7218	748	81	;	;	PUNCT
bam-7218	748	82	(	(	PUNCT
bam-7218	748	83	c	c	X
bam-7218	748	84	)	)	PUNCT
bam-7218	748	85	dipartimento	dipartimento	ADP
bam-7218	748	86	di	di	PROPN
bam-7218	748	87	medicina	medicina	PROPN
bam-7218	748	88	sperimentale	sperimentale	PROPN
bam-7218	748	89	,	,	PUNCT
bam-7218	748	90	sanità	sanità	PROPN
bam-7218	748	91	pubblica	pubblica	PROPN
bam-7218	748	92	forense	forense	PROPN
bam-7218	748	93	,	,	PUNCT
bam-7218	748	94	università	università	PROPN
bam-7218	748	95	di	di	PROPN
bam-7218	748	96	pavia	pavia	PROPN
bam-7218	748	97	,	,	PUNCT
bam-7218	748	98	italy	italy	PROPN
bam-7218	748	99	.	.	PUNCT
bam-7218	749	1	e	e	X
bam-7218	749	2	-	-	NOUN
bam-7218	749	3	mail	mail	NOUN
bam-7218	749	4	:	:	PUNCT
bam-7218	749	5	hana.sustova@med.uniupo.it	hana.sustova@med.uniupo.it	VERB
bam-7218	749	6	the	the	DET
bam-7218	749	7	dystrophin	dystrophin	NOUN
bam-7218	749	8	-	-	PUNCT
bam-7218	749	9	associated	associate	VERB
bam-7218	749	10	glycoprotein	glycoprotein	NOUN
bam-7218	749	11	complex	complex	NOUN
bam-7218	749	12	(	(	PUNCT
bam-7218	749	13	dgc	dgc	NOUN
bam-7218	749	14	)	)	PUNCT
bam-7218	749	15	serves	serve	VERB
bam-7218	749	16	as	as	ADP
bam-7218	749	17	a	a	DET
bam-7218	749	18	mechanical	mechanical	ADJ
bam-7218	749	19	link	link	NOUN
bam-7218	749	20	between	between	ADP
bam-7218	749	21	the	the	DET
bam-7218	749	22	cytoskeleton	cytoskeleton	PROPN
bam-7218	749	23	and	and	CCONJ
bam-7218	749	24	the	the	DET
bam-7218	749	25	extracellular	extracellular	ADJ
bam-7218	749	26	matrix	matrix	NOUN
bam-7218	749	27	of	of	ADP
bam-7218	749	28	muscle	muscle	NOUN
bam-7218	749	29	cells	cell	NOUN
bam-7218	749	30	.	.	PUNCT
bam-7218	750	1	disassembly	disassembly	ADV
bam-7218	750	2	of	of	ADP
bam-7218	750	3	this	this	DET
bam-7218	750	4	protein	protein	NOUN
bam-7218	750	5	complex	complex	NOUN
bam-7218	750	6	renders	render	VERB
bam-7218	750	7	the	the	DET
bam-7218	750	8	sarcolemma	sarcolemma	PROPN
bam-7218	750	9	vulnerable	vulnerable	ADJ
bam-7218	750	10	to	to	ADP
bam-7218	750	11	contraction	contraction	NOUN
bam-7218	750	12	-	-	PUNCT
bam-7218	750	13	induced	induce	VERB
bam-7218	750	14	injury	injury	NOUN
bam-7218	750	15	,	,	PUNCT
bam-7218	750	16	leading	lead	VERB
bam-7218	750	17	to	to	ADP
bam-7218	750	18	progressive	progressive	ADJ
bam-7218	750	19	fiber	fiber	NOUN
bam-7218	750	20	damage	damage	NOUN
bam-7218	750	21	,	,	PUNCT
bam-7218	750	22	membrane	membrane	NOUN
bam-7218	750	23	leakage	leakage	NOUN
bam-7218	750	24	and	and	CCONJ
bam-7218	750	25	cell	cell	NOUN
bam-7218	750	26	death	death	NOUN
bam-7218	750	27	.	.	PUNCT
bam-7218	751	1	dgc	dgc	NOUN
bam-7218	751	2	interacts	interact	VERB
bam-7218	751	3	with	with	ADP
bam-7218	751	4	filamentous	filamentous	ADJ
bam-7218	751	5	-	-	PUNCT
bam-7218	751	6	actin	actin	NOUN
bam-7218	751	7	(	(	PUNCT
bam-7218	751	8	f	f	NOUN
bam-7218	751	9	-	-	PUNCT
bam-7218	751	10	actin	actin	NOUN
bam-7218	751	11	)	)	PUNCT
bam-7218	751	12	fine	fine	NOUN
bam-7218	751	13	regulated	regulate	VERB
bam-7218	751	14	by	by	ADP
bam-7218	751	15	microtubule	microtubule	NOUN
bam-7218	751	16	associated	associate	VERB
bam-7218	751	17	monooxygenase	monooxygenase	NOUN
bam-7218	751	18	,	,	PUNCT
bam-7218	751	19	calponin	calponin	NOUN
bam-7218	751	20	and	and	CCONJ
bam-7218	751	21	lim	lim	PROPN
bam-7218	751	22	domain	domain	NOUN
bam-7218	751	23	containing	contain	VERB
bam-7218	751	24	2	2	NUM
bam-7218	751	25	(	(	PUNCT
bam-7218	751	26	mical2	mical2	NOUN
bam-7218	751	27	)	)	PUNCT
bam-7218	751	28	.	.	PUNCT
bam-7218	752	1	indeed	indeed	ADV
bam-7218	752	2	,	,	PUNCT
bam-7218	752	3	mical2	mical2	NOUN
bam-7218	752	4	modifies	modify	VERB
bam-7218	752	5	actin	actin	NOUN
bam-7218	752	6	subunits	subunit	NOUN
bam-7218	752	7	and	and	CCONJ
bam-7218	752	8	promotes	promote	VERB
bam-7218	752	9	actin	actin	NOUN
bam-7218	752	10	filament	filament	NOUN
bam-7218	752	11	turnover	turnover	NOUN
bam-7218	752	12	by	by	ADP
bam-7218	752	13	severing	sever	VERB
bam-7218	752	14	disaggregation	disaggregation	NOUN
bam-7218	752	15	and	and	CCONJ
bam-7218	752	16	preventing	prevent	VERB
bam-7218	752	17	repolymerization	repolymerization	NOUN
bam-7218	752	18	.	.	PUNCT
bam-7218	753	1	mical2	mical2	NOUN
bam-7218	753	2	has	have	AUX
bam-7218	753	3	been	be	AUX
bam-7218	753	4	shown	show	VERB
bam-7218	753	5	to	to	PART
bam-7218	753	6	transduce	transduce	VERB
bam-7218	753	7	semaphorin	semaphorin	NOUN
bam-7218	753	8	/	/	SYM
bam-7218	753	9	plexin	plexin	PROPN
bam-7218	753	10	external	external	NOUN
bam-7218	753	11	signaling	signal	VERB
bam-7218	753	12	into	into	ADP
bam-7218	753	13	cytoskeletal	cytoskeletal	ADJ
bam-7218	753	14	modifications	modification	NOUN
bam-7218	754	1	[	[	X
bam-7218	754	2	1	1	NUM
bam-7218	754	3	]	]	PUNCT
bam-7218	754	4	.	.	PUNCT
bam-7218	755	1	interestingly	interestingly	ADV
bam-7218	755	2	,	,	PUNCT
bam-7218	755	3	in	in	ADP
bam-7218	755	4	a	a	DET
bam-7218	755	5	genome	genome	NOUN
bam-7218	755	6	profiling	profiling	NOUN
bam-7218	755	7	study	study	NOUN
bam-7218	755	8	,	,	PUNCT
bam-7218	755	9	mical2	mical2	NOUN
bam-7218	755	10	has	have	AUX
bam-7218	755	11	been	be	AUX
bam-7218	755	12	found	find	VERB
bam-7218	755	13	among	among	ADP
bam-7218	755	14	a	a	DET
bam-7218	755	15	set	set	NOUN
bam-7218	755	16	of	of	ADP
bam-7218	755	17	ten	ten	NUM
bam-7218	755	18	functionally	functionally	ADV
bam-7218	755	19	linked	link	VERB
bam-7218	755	20	genes	gene	NOUN
bam-7218	755	21	involved	involve	VERB
bam-7218	755	22	in	in	ADP
bam-7218	755	23	muscle	muscle	NOUN
bam-7218	755	24	degenerations	degeneration	NOUN
bam-7218	755	25	of	of	ADP
bam-7218	755	26	mdx	mdx	NOUN
bam-7218	755	27	mice	mouse	NOUN
bam-7218	755	28	[	[	X
bam-7218	755	29	2	2	NUM
bam-7218	755	30	]	]	PUNCT
bam-7218	755	31	.	.	PUNCT
bam-7218	756	1	in	in	ADP
bam-7218	756	2	this	this	DET
bam-7218	756	3	study	study	NOUN
bam-7218	756	4	,	,	PUNCT
bam-7218	756	5	we	we	PRON
bam-7218	756	6	focus	focus	VERB
bam-7218	756	7	on	on	ADP
bam-7218	756	8	the	the	DET
bam-7218	756	9	role	role	NOUN
bam-7218	756	10	of	of	ADP
bam-7218	756	11	mical2	mical2	NOUN
bam-7218	756	12	in	in	ADP
bam-7218	756	13	skeletal	skeletal	ADJ
bam-7218	756	14	,	,	PUNCT
bam-7218	756	15	cardiac	cardiac	ADJ
bam-7218	756	16	and	and	CCONJ
bam-7218	756	17	smooth	smooth	ADJ
bam-7218	756	18	muscle	muscle	NOUN
bam-7218	756	19	differentiation	differentiation	NOUN
bam-7218	756	20	.	.	PUNCT
bam-7218	757	1	in	in	ADP
bam-7218	757	2	particular	particular	ADJ
bam-7218	757	3	,	,	PUNCT
bam-7218	757	4	we	we	PRON
bam-7218	757	5	found	find	VERB
bam-7218	757	6	that	that	SCONJ
bam-7218	757	7	mical2	mical2	NOUN
bam-7218	757	8	increases	increase	NOUN
bam-7218	757	9	during	during	ADP
bam-7218	757	10	myogenic	myogenic	ADJ
bam-7218	757	11	differentiation	differentiation	NOUN
bam-7218	757	12	of	of	ADP
bam-7218	757	13	c2c12	c2c12	PROPN
bam-7218	757	14	cells	cell	NOUN
bam-7218	757	15	and	and	CCONJ
bam-7218	757	16	primary	primary	ADJ
bam-7218	757	17	satellite	satellite	NOUN
bam-7218	757	18	cells	cell	NOUN
bam-7218	757	19	.	.	PUNCT
bam-7218	758	1	intriguingly	intriguingly	ADV
bam-7218	758	2	,	,	PUNCT
bam-7218	758	3	perturbation	perturbation	NOUN
bam-7218	758	4	studies	study	NOUN
bam-7218	758	5	of	of	ADP
bam-7218	758	6	mical2	mical2	NOUN
bam-7218	758	7	levels	level	NOUN
bam-7218	758	8	impair	impair	VERB
bam-7218	758	9	myogenic	myogenic	ADJ
bam-7218	758	10	differentiation	differentiation	NOUN
bam-7218	758	11	,	,	PUNCT
bam-7218	758	12	both	both	PRON
bam-7218	758	13	in	in	ADP
bam-7218	758	14	c2c12	c2c12	PROPN
bam-7218	758	15	and	and	CCONJ
bam-7218	758	16	satellite	satellite	NOUN
bam-7218	758	17	cells	cell	NOUN
bam-7218	758	18	.	.	PUNCT
bam-7218	759	1	murine	murine	ADJ
bam-7218	759	2	mesoangioblasts	mesoangioblast	NOUN
bam-7218	759	3	,	,	PUNCT
bam-7218	759	4	vessel	vessel	NOUN
bam-7218	759	5	associated	associate	VERB
bam-7218	759	6	stem	stem	NOUN
bam-7218	759	7	cells	cell	NOUN
bam-7218	759	8	,	,	PUNCT
bam-7218	759	9	also	also	ADV
bam-7218	759	10	express	express	VERB
bam-7218	759	11	high	high	ADJ
bam-7218	759	12	levels	level	NOUN
bam-7218	759	13	of	of	ADP
bam-7218	759	14	mical2	mical2	NOUN
bam-7218	759	15	when	when	SCONJ
bam-7218	759	16	differentiated	differentiate	VERB
bam-7218	759	17	into	into	ADP
bam-7218	759	18	smooth	smooth	ADJ
bam-7218	759	19	muscle	muscle	NOUN
bam-7218	759	20	cells	cell	NOUN
bam-7218	759	21	.	.	PUNCT
bam-7218	760	1	finally	finally	ADV
bam-7218	760	2	,	,	PUNCT
bam-7218	760	3	murine	murine	ADJ
bam-7218	760	4	hearts	heart	NOUN
bam-7218	760	5	express	express	VERB
bam-7218	760	6	mical2	mical2	NOUN
bam-7218	760	7	protein	protein	NOUN
bam-7218	760	8	both	both	CCONJ
bam-7218	760	9	in	in	ADP
bam-7218	760	10	embryonal	embryonal	ADJ
bam-7218	760	11	and	and	CCONJ
bam-7218	760	12	adult	adult	NOUN
bam-7218	760	13	conditions	condition	NOUN
bam-7218	760	14	,	,	PUNCT
bam-7218	760	15	as	as	ADV
bam-7218	760	16	well	well	ADV
bam-7218	760	17	as	as	ADP
bam-7218	760	18	human	human	ADJ
bam-7218	760	19	induced	induced	ADJ
bam-7218	760	20	pluripotent	pluripotent	ADJ
bam-7218	760	21	stem	stem	NOUN
bam-7218	760	22	cells	cell	NOUN
bam-7218	760	23	during	during	ADP
bam-7218	760	24	differentiation	differentiation	NOUN
bam-7218	760	25	into	into	ADP
bam-7218	760	26	cardiomyocytes	cardiomyocyte	NOUN
bam-7218	760	27	.	.	PUNCT
bam-7218	761	1	taken	take	VERB
bam-7218	761	2	together	together	ADV
bam-7218	761	3	,	,	PUNCT
bam-7218	761	4	these	these	DET
bam-7218	761	5	data	datum	NOUN
bam-7218	761	6	demonstrate	demonstrate	VERB
bam-7218	761	7	that	that	SCONJ
bam-7218	761	8	modulations	modulation	NOUN
bam-7218	761	9	of	of	ADP
bam-7218	761	10	mical2	mical2	NOUN
bam-7218	761	11	have	have	VERB
bam-7218	761	12	an	an	DET
bam-7218	761	13	impact	impact	NOUN
bam-7218	761	14	on	on	ADP
bam-7218	761	15	muscle	muscle	NOUN
bam-7218	761	16	differentiations	differentiation	NOUN
bam-7218	761	17	.	.	PUNCT
bam-7218	762	1	further	further	ADJ
bam-7218	762	2	experiments	experiment	NOUN
bam-7218	762	3	are	be	AUX
bam-7218	762	4	necessary	necessary	ADJ
bam-7218	762	5	to	to	PART
bam-7218	762	6	understand	understand	VERB
bam-7218	762	7	whether	whether	SCONJ
bam-7218	762	8	the	the	DET
bam-7218	762	9	absence	absence	NOUN
bam-7218	762	10	of	of	ADP
bam-7218	762	11	mical2	mical2	NOUN
bam-7218	762	12	affects	affect	VERB
bam-7218	762	13	smooth	smooth	ADJ
bam-7218	762	14	and	and	CCONJ
bam-7218	762	15	cardiac	cardiac	ADJ
bam-7218	762	16	muscle	muscle	NOUN
bam-7218	762	17	differentiation	differentiation	NOUN
bam-7218	762	18	.	.	PUNCT
bam-7218	763	1	moreover	moreover	ADV
bam-7218	763	2	,	,	PUNCT
bam-7218	763	3	gain	gain	NOUN
bam-7218	763	4	-	-	PUNCT
bam-7218	763	5	offunction	offunction	NOUN
bam-7218	763	6	experiments	experiment	NOUN
bam-7218	763	7	might	might	AUX
bam-7218	763	8	shed	shed	VERB
bam-7218	763	9	light	light	NOUN
bam-7218	763	10	on	on	ADP
bam-7218	763	11	the	the	DET
bam-7218	763	12	role	role	NOUN
bam-7218	763	13	of	of	ADP
bam-7218	763	14	mical2	mical2	NOUN
bam-7218	763	15	in	in	ADP
bam-7218	763	16	myogenic	myogenic	ADJ
bam-7218	763	17	commitments	commitment	NOUN
bam-7218	763	18	.	.	PUNCT
bam-7218	764	1	references	reference	NOUN
bam-7218	764	2	:	:	PUNCT
bam-7218	764	3	1	1	X
bam-7218	764	4	.	.	X
bam-7218	764	5	lundquist	lundquist	PROPN
bam-7218	764	6	et	et	PROPN
bam-7218	764	7	al	al	PROPN
bam-7218	764	8	.	.	PROPN
bam-7218	765	1	(	(	PUNCT
bam-7218	765	2	2014	2014	NUM
bam-7218	765	3	)	)	PUNCT
bam-7218	765	4	redox	redox	NOUN
bam-7218	765	5	modification	modification	NOUN
bam-7218	765	6	of	of	ADP
bam-7218	765	7	nuclear	nuclear	ADJ
bam-7218	765	8	actin	actin	NOUN
bam-7218	765	9	by	by	ADP
bam-7218	765	10	mical-2	mical-2	PRON
bam-7218	765	11	regulates	regulate	VERB
bam-7218	765	12	srf	srf	ADJ
bam-7218	765	13	signaling	signal	VERB
bam-7218	765	14	.	.	PUNCT
bam-7218	766	1	cell	cell	NOUN
bam-7218	766	2	.	.	PUNCT
bam-7218	767	1	156(3):563	156(3):563	PROPN
bam-7218	767	2	-	-	PUNCT
bam-7218	767	3	76	76	NUM
bam-7218	767	4	.	.	PUNCT
bam-7218	768	1	2	2	NUM
bam-7218	768	2	.	.	X
bam-7218	768	3	marotta	marotta	PROPN
bam-7218	768	4	et	et	PROPN
bam-7218	768	5	al	al	PROPN
bam-7218	768	6	.	.	PROPN
bam-7218	769	1	(	(	PUNCT
bam-7218	769	2	2009	2009	NUM
bam-7218	769	3	)	)	PUNCT
bam-7218	769	4	muscle	muscle	NOUN
bam-7218	769	5	genomemailto:alessio.rotini@gmail.com	genomemailto:alessio.rotini@gmail.com	PROPN
bam-7218	769	6	mailto:hana.sustova@med.uniupo.it	mailto:hana.sustova@med.uniupo.it	PUNCT
bam-7218	769	7	14	14	NUM
bam-7218	769	8	th	th	NUM
bam-7218	769	9	iiim	iiim	NOUN
bam-7218	769	10	meeting	meeting	NOUN
bam-7218	769	11	,	,	PUNCT
bam-7218	769	12	assisi	assisi	PROPN
bam-7218	769	13	,	,	PUNCT
bam-7218	769	14	italy	italy	PROPN
bam-7218	769	15	october	october	PROPN
bam-7218	769	16	12	12	NUM
bam-7218	769	17	-	-	SYM
bam-7218	769	18	15	15	NUM
bam-7218	769	19	2017	2017	NUM
bam-7218	769	20	eur	eur	PROPN
bam-7218	769	21	j	j	PROPN
bam-7218	769	22	transl	transl	PROPN
bam-7218	769	23	myol	myol	ADV
bam-7218	769	24	27	27	NUM
bam-7218	769	25	(	(	PUNCT
bam-7218	769	26	4	4	NUM
bam-7218	769	27	):	):	SYM
bam-7218	769	28	185	185	NUM
bam-7218	769	29	-	-	SYM
bam-7218	769	30	224	224	NUM
bam-7218	769	31	208	208	NUM
bam-7218	769	32	wide	wide	ADJ
bam-7218	769	33	expression	expression	NOUN
bam-7218	769	34	profiling	profiling	NOUN
bam-7218	769	35	during	during	ADP
bam-7218	769	36	disease	disease	NOUN
bam-7218	769	37	evolution	evolution	NOUN
bam-7218	769	38	in	in	ADP
bam-7218	769	39	mdx	mdx	NOUN
bam-7218	769	40	mice	mouse	NOUN
bam-7218	769	41	.	.	PUNCT
bam-7218	770	1	physiol	physiol	PROPN
bam-7218	770	2	genomics	genomics	PROPN
bam-7218	770	3	.	.	PUNCT
bam-7218	771	1	37(2):119	37(2):119	NUM
bam-7218	771	2	-	-	SYM
bam-7218	771	3	32	32	NUM
bam-7218	771	4	.	.	PUNCT
bam-7218	772	1	7.6	7.6	NUM
bam-7218	772	2	25(oh	25(oh	NUM
bam-7218	772	3	)	)	PUNCT
bam-7218	772	4	vitamin	vitamin	NOUN
bam-7218	772	5	d3	d3	PROPN
bam-7218	772	6	protects	protect	VERB
bam-7218	772	7	from	from	ADP
bam-7218	772	8	atrophy	atrophy	NOUN
bam-7218	772	9	in	in	ADP
bam-7218	772	10	vitro	vitro	X
bam-7218	772	11	hana	hana	PROPN
bam-7218	772	12	sustova	sustova	PROPN
bam-7218	772	13	,	,	PUNCT
bam-7218	772	14	marilisa	marilisa	NOUN
bam-7218	772	15	de	de	X
bam-7218	772	16	feudis	feudi	NOUN
bam-7218	772	17	,	,	PUNCT
bam-7218	772	18	simone	simone	PROPN
bam-7218	772	19	reano	reano	PROPN
bam-7218	772	20	,	,	PUNCT
bam-7218	772	21	flavia	flavia	PROPN
bam-7218	772	22	prodam	prodam	PROPN
bam-7218	772	23	,	,	PUNCT
bam-7218	772	24	nicoletta	nicoletta	PROPN
bam-7218	772	25	filigheddu	filigheddu	PROPN
bam-7218	772	26	dept	dept	NOUN
bam-7218	772	27	of	of	ADP
bam-7218	772	28	translational	translational	ADJ
bam-7218	772	29	medicine	medicine	NOUN
bam-7218	772	30	,	,	PUNCT
bam-7218	772	31	university	university	NOUN
bam-7218	772	32	of	of	ADP
bam-7218	772	33	piemonte	piemonte	PROPN
bam-7218	772	34	orientale	orientale	PROPN
bam-7218	772	35	,	,	PUNCT
bam-7218	772	36	italy	italy	PROPN
bam-7218	772	37	.	.	PUNCT
bam-7218	773	1	e	e	X
bam-7218	773	2	-	-	NOUN
bam-7218	773	3	mail	mail	NOUN
bam-7218	773	4	:	:	PUNCT
bam-7218	773	5	hana.sustova@med.uniupo.it	hana.sustova@med.uniupo.it	NUM
bam-7218	773	6	cachexia	cachexia	NOUN
bam-7218	773	7	is	be	AUX
bam-7218	773	8	a	a	DET
bam-7218	773	9	common	common	ADJ
bam-7218	773	10	complication	complication	NOUN
bam-7218	773	11	of	of	ADP
bam-7218	773	12	cancer	cancer	NOUN
bam-7218	773	13	characterized	characterize	VERB
bam-7218	773	14	by	by	ADP
bam-7218	773	15	several	several	ADJ
bam-7218	773	16	metabolic	metabolic	NOUN
bam-7218	773	17	alterations	alteration	NOUN
bam-7218	773	18	and	and	CCONJ
bam-7218	773	19	a	a	DET
bam-7218	773	20	massive	massive	ADJ
bam-7218	773	21	skeletal	skeletal	ADJ
bam-7218	773	22	mass	mass	NOUN
bam-7218	773	23	loss	loss	NOUN
bam-7218	773	24	occurring	occur	VERB
bam-7218	773	25	in	in	ADP
bam-7218	773	26	up	up	ADP
bam-7218	773	27	to	to	PART
bam-7218	773	28	60	60	NUM
bam-7218	773	29	%	%	NOUN
bam-7218	773	30	of	of	ADP
bam-7218	773	31	cancer	cancer	NOUN
bam-7218	773	32	patients	patient	NOUN
bam-7218	773	33	.	.	PUNCT
bam-7218	774	1	in	in	ADP
bam-7218	774	2	addition	addition	NOUN
bam-7218	774	3	to	to	ADP
bam-7218	774	4	increasing	increase	VERB
bam-7218	774	5	morbidity	morbidity	NOUN
bam-7218	774	6	and	and	CCONJ
bam-7218	774	7	mortality	mortality	NOUN
bam-7218	774	8	,	,	PUNCT
bam-7218	774	9	aggravating	aggravate	VERB
bam-7218	774	10	the	the	DET
bam-7218	774	11	side	side	NOUN
bam-7218	774	12	effects	effect	NOUN
bam-7218	774	13	of	of	ADP
bam-7218	774	14	chemotherapy	chemotherapy	NOUN
bam-7218	774	15	,	,	PUNCT
bam-7218	774	16	and	and	CCONJ
bam-7218	774	17	reducing	reduce	VERB
bam-7218	774	18	quality	quality	NOUN
bam-7218	774	19	of	of	ADP
bam-7218	774	20	life	life	NOUN
bam-7218	774	21	,	,	PUNCT
bam-7218	774	22	cachexia	cachexia	PROPN
bam-7218	774	23	is	be	AUX
bam-7218	774	24	considered	consider	VERB
bam-7218	774	25	the	the	DET
bam-7218	774	26	direct	direct	ADJ
bam-7218	774	27	cause	cause	NOUN
bam-7218	774	28	of	of	ADP
bam-7218	774	29	death	death	NOUN
bam-7218	774	30	of	of	ADP
bam-7218	774	31	a	a	DET
bam-7218	774	32	large	large	ADJ
bam-7218	774	33	proportion	proportion	NOUN
bam-7218	774	34	of	of	ADP
bam-7218	774	35	cancer	cancer	NOUN
bam-7218	774	36	patients	patient	NOUN
bam-7218	774	37	.	.	PUNCT
bam-7218	775	1	however	however	ADV
bam-7218	775	2	,	,	PUNCT
bam-7218	775	3	no	no	DET
bam-7218	775	4	efficacious	efficacious	ADJ
bam-7218	775	5	treatment	treatment	NOUN
bam-7218	775	6	exists	exist	VERB
bam-7218	775	7	today	today	NOUN
bam-7218	775	8	.	.	PUNCT
bam-7218	776	1	25(oh	25(oh	X
bam-7218	776	2	)	)	PUNCT
bam-7218	776	3	vitamin	vitamin	NOUN
bam-7218	776	4	d3	d3	PROPN
bam-7218	776	5	(	(	PUNCT
bam-7218	776	6	25ohd	25ohd	NOUN
bam-7218	776	7	)	)	PUNCT
bam-7218	776	8	blood	blood	NOUN
bam-7218	776	9	levels	level	NOUN
bam-7218	776	10	have	have	AUX
bam-7218	776	11	been	be	AUX
bam-7218	776	12	correlated	correlate	VERB
bam-7218	776	13	with	with	ADP
bam-7218	776	14	the	the	DET
bam-7218	776	15	incidence	incidence	NOUN
bam-7218	776	16	and	and	CCONJ
bam-7218	776	17	evolution	evolution	NOUN
bam-7218	776	18	of	of	ADP
bam-7218	776	19	some	some	DET
bam-7218	776	20	cancers	cancer	NOUN
bam-7218	776	21	,	,	PUNCT
bam-7218	776	22	suggesting	suggest	VERB
bam-7218	776	23	that	that	SCONJ
bam-7218	776	24	vitamin	vitamin	NOUN
bam-7218	776	25	d	d	X
bam-7218	776	26	(	(	PUNCT
bam-7218	776	27	vd	vd	NOUN
bam-7218	776	28	)	)	PUNCT
bam-7218	776	29	can	can	AUX
bam-7218	776	30	play	play	VERB
bam-7218	776	31	a	a	DET
bam-7218	776	32	role	role	NOUN
bam-7218	776	33	in	in	ADP
bam-7218	776	34	improving	improve	VERB
bam-7218	776	35	patients	patient	NOUN
bam-7218	776	36	’	'	PUNCT
bam-7218	776	37	prognosis	prognosis	NOUN
bam-7218	776	38	.	.	PUNCT
bam-7218	777	1	vd	vd	NOUN
bam-7218	777	2	has	have	AUX
bam-7218	777	3	been	be	AUX
bam-7218	777	4	also	also	ADV
bam-7218	777	5	shown	show	VERB
bam-7218	777	6	to	to	PART
bam-7218	777	7	be	be	AUX
bam-7218	777	8	important	important	ADJ
bam-7218	777	9	in	in	ADP
bam-7218	777	10	the	the	DET
bam-7218	777	11	maintenance	maintenance	NOUN
bam-7218	777	12	of	of	ADP
bam-7218	777	13	muscle	muscle	NOUN
bam-7218	777	14	homeostasis	homeostasis	NOUN
bam-7218	777	15	and	and	CCONJ
bam-7218	777	16	functionality	functionality	NOUN
bam-7218	777	17	.	.	PUNCT
bam-7218	778	1	this	this	PRON
bam-7218	778	2	led	lead	VERB
bam-7218	778	3	to	to	ADP
bam-7218	778	4	the	the	DET
bam-7218	778	5	hypothesis	hypothesis	NOUN
bam-7218	778	6	of	of	ADP
bam-7218	778	7	using	use	VERB
bam-7218	778	8	vd	vd	NOUN
bam-7218	778	9	as	as	ADP
bam-7218	778	10	anti	anti	ADJ
bam-7218	778	11	-	-	ADJ
bam-7218	778	12	cachectic	cachectic	ADJ
bam-7218	778	13	treatment	treatment	NOUN
bam-7218	778	14	,	,	PUNCT
bam-7218	778	15	but	but	CCONJ
bam-7218	778	16	the	the	DET
bam-7218	778	17	direct	direct	ADJ
bam-7218	778	18	effect	effect	NOUN
bam-7218	778	19	of	of	ADP
bam-7218	778	20	vd	vd	NOUN
bam-7218	778	21	supplementation	supplementation	NOUN
bam-7218	778	22	on	on	ADP
bam-7218	778	23	muscle	muscle	NOUN
bam-7218	778	24	and	and	CCONJ
bam-7218	778	25	its	its	PRON
bam-7218	778	26	mechanism	mechanism	NOUN
bam-7218	778	27	are	be	AUX
bam-7218	778	28	still	still	ADV
bam-7218	778	29	not	not	PART
bam-7218	778	30	clear	clear	ADJ
bam-7218	778	31	.	.	PUNCT
bam-7218	779	1	here	here	ADV
bam-7218	779	2	we	we	PRON
bam-7218	779	3	show	show	VERB
bam-7218	779	4	that	that	SCONJ
bam-7218	779	5	25ohd	25ohd	PROPN
bam-7218	779	6	protects	protect	VERB
bam-7218	779	7	c2c12	c2c12	PROPN
bam-7218	779	8	myotubes	myotube	NOUN
bam-7218	779	9	from	from	ADP
bam-7218	779	10	cytokineinduced	cytokineinduce	VERB
bam-7218	779	11	atrophy	atrophy	NOUN
bam-7218	779	12	by	by	ADP
bam-7218	779	13	activating	activate	VERB
bam-7218	779	14	akt	akt	PROPN
bam-7218	779	15	-	-	PUNCT
bam-7218	779	16	foxo3	foxo3	PROPN
bam-7218	779	17	signaling	signaling	NOUN
bam-7218	779	18	,	,	PUNCT
bam-7218	779	19	and	and	CCONJ
bam-7218	779	20	that	that	SCONJ
bam-7218	779	21	the	the	DET
bam-7218	779	22	intracellular	intracellular	ADJ
bam-7218	779	23	conversion	conversion	NOUN
bam-7218	779	24	of	of	ADP
bam-7218	779	25	25ohd	25ohd	NOUN
bam-7218	779	26	to	to	ADP
bam-7218	779	27	1,25(oh)2	1,25(oh)2	PROPN
bam-7218	779	28	vitamin	vitamin	NOUN
bam-7218	779	29	d3	d3	PROPN
bam-7218	779	30	is	be	AUX
bam-7218	779	31	crucial	crucial	ADJ
bam-7218	779	32	for	for	ADP
bam-7218	779	33	its	its	PRON
bam-7218	779	34	anti	anti	ADJ
bam-7218	779	35	-	-	ADJ
bam-7218	779	36	atrophic	atrophic	ADJ
bam-7218	779	37	function	function	NOUN
bam-7218	779	38	.	.	PUNCT
bam-7218	780	1	moreover	moreover	ADV
bam-7218	780	2	,	,	PUNCT
bam-7218	780	3	25ohd	25ohd	NUM
bam-7218	780	4	treatment	treatment	NOUN
bam-7218	780	5	promotes	promote	VERB
bam-7218	780	6	hypertrophy	hypertrophy	NOUN
bam-7218	780	7	.	.	PUNCT
bam-7218	781	1	altogether	altogether	ADV
bam-7218	781	2	,	,	PUNCT
bam-7218	781	3	our	our	PRON
bam-7218	781	4	data	datum	NOUN
bam-7218	781	5	indicate	indicate	VERB
bam-7218	781	6	that	that	SCONJ
bam-7218	781	7	25ohd	25ohd	NOUN
bam-7218	781	8	has	have	VERB
bam-7218	781	9	a	a	DET
bam-7218	781	10	protective	protective	ADJ
bam-7218	781	11	effect	effect	NOUN
bam-7218	781	12	on	on	ADP
bam-7218	781	13	skeletal	skeletal	ADJ
bam-7218	781	14	muscle	muscle	NOUN
bam-7218	781	15	cells	cell	NOUN
bam-7218	781	16	in	in	ADP
bam-7218	781	17	vitro	vitro	VERB
bam-7218	781	18	.	.	PUNCT
bam-7218	782	1	thus	thus	ADV
bam-7218	782	2	,	,	PUNCT
bam-7218	782	3	25ohd	25ohd	PROPN
bam-7218	782	4	could	could	AUX
bam-7218	782	5	be	be	AUX
bam-7218	782	6	a	a	DET
bam-7218	782	7	possible	possible	ADJ
bam-7218	782	8	candidate	candidate	NOUN
bam-7218	782	9	for	for	ADP
bam-7218	782	10	further	further	ADJ
bam-7218	782	11	studies	study	NOUN
bam-7218	782	12	in	in	ADP
bam-7218	782	13	cancer	cancer	NOUN
bam-7218	782	14	-	-	PUNCT
bam-7218	782	15	cachexia	cachexia	NOUN
bam-7218	782	16	treatment	treatment	NOUN
bam-7218	782	17	.	.	PUNCT
bam-7218	783	1	poster	poster	NOUN
bam-7218	783	2	session	session	NOUN
bam-7218	783	3	:	:	PUNCT
bam-7218	783	4	always	always	ADV
bam-7218	783	5	on	on	ADP
bam-7218	783	6	display	display	NOUN
bam-7218	783	7	p.01	p.01	DET
bam-7218	783	8	evaluation	evaluation	NOUN
bam-7218	783	9	of	of	ADP
bam-7218	783	10	anti	anti	ADJ
bam-7218	783	11	-	-	ADJ
bam-7218	783	12	atrophic	atrophic	ADJ
bam-7218	783	13	activity	activity	NOUN
bam-7218	783	14	of	of	ADP
bam-7218	783	15	anamorelin	anamorelin	NOUN
bam-7218	783	16	in	in	ADP
bam-7218	783	17	models	model	NOUN
bam-7218	783	18	of	of	ADP
bam-7218	783	19	muscle	muscle	NOUN
bam-7218	783	20	wasting	waste	VERB
bam-7218	783	21	emanuela	emanuela	PROPN
bam-7218	783	22	agosti	agosti	NOUN
bam-7218	783	23	(	(	PUNCT
bam-7218	783	24	a	a	NOUN
bam-7218	783	25	)	)	PUNCT
bam-7218	783	26	,	,	PUNCT
bam-7218	783	27	sara	sara	PROPN
bam-7218	783	28	clerici	clerici	PROPN
bam-7218	783	29	(	(	PUNCT
bam-7218	783	30	b	b	NOUN
bam-7218	783	31	)	)	PUNCT
bam-7218	783	32	,	,	PUNCT
bam-7218	783	33	michele	michele	PROPN
bam-7218	783	34	ferrara	ferrara	PROPN
bam-7218	783	35	(	(	PUNCT
bam-7218	783	36	b	b	NOUN
bam-7218	783	37	)	)	PUNCT
bam-7218	783	38	,	,	PUNCT
bam-7218	783	39	elia	elia	PROPN
bam-7218	783	40	angelino	angelino	PROPN
bam-7218	783	41	(	(	PUNCT
bam-7218	783	42	b	b	NOUN
bam-7218	783	43	)	)	PUNCT
bam-7218	783	44	,	,	PUNCT
bam-7218	783	45	simone	simone	NOUN
bam-7218	783	46	reano	reano	X
bam-7218	783	47	(	(	PUNCT
bam-7218	783	48	a	a	X
bam-7218	783	49	)	)	PUNCT
bam-7218	783	50	,	,	PUNCT
bam-7218	783	51	nicoletta	nicoletta	PROPN
bam-7218	783	52	filigheddu	filigheddu	PROPN
bam-7218	783	53	(	(	PUNCT
bam-7218	783	54	a	a	X
bam-7218	783	55	)	)	PUNCT
bam-7218	783	56	,	,	PUNCT
bam-7218	783	57	andrea	andrea	PROPN
bam-7218	783	58	graziani	graziani	PROPN
bam-7218	783	59	(	(	PUNCT
bam-7218	783	60	b	b	NOUN
bam-7218	783	61	)	)	PUNCT
bam-7218	783	62	(	(	PUNCT
bam-7218	783	63	a	a	X
bam-7218	783	64	)	)	PUNCT
bam-7218	783	65	dept	dept	NOUN
bam-7218	783	66	of	of	ADP
bam-7218	783	67	translational	translational	ADJ
bam-7218	783	68	medicine	medicine	NOUN
bam-7218	783	69	,	,	PUNCT
bam-7218	783	70	university	university	NOUN
bam-7218	783	71	of	of	ADP
bam-7218	783	72	piemonte	piemonte	PROPN
bam-7218	783	73	orientale	orientale	PROPN
bam-7218	783	74	,	,	PUNCT
bam-7218	783	75	novara	novara	PROPN
bam-7218	783	76	;	;	PUNCT
bam-7218	783	77	(	(	PUNCT
bam-7218	783	78	b	b	X
bam-7218	783	79	)	)	PUNCT
bam-7218	783	80	dept	dept	NOUN
bam-7218	783	81	of	of	ADP
bam-7218	783	82	experimental	experimental	ADJ
bam-7218	783	83	oncology	oncology	NOUN
bam-7218	783	84	,	,	PUNCT
bam-7218	783	85	university	university	NOUN
bam-7218	783	86	vita	vita	NOUN
bam-7218	783	87	-	-	PUNCT
bam-7218	783	88	salute	salute	NOUN
bam-7218	783	89	san	san	PROPN
bam-7218	783	90	raffaele	raffaele	PROPN
bam-7218	783	91	,	,	PUNCT
bam-7218	783	92	milano	milano	PROPN
bam-7218	783	93	,	,	PUNCT
bam-7218	783	94	italy	italy	PROPN
bam-7218	783	95	.	.	PUNCT
bam-7218	784	1	e	e	X
bam-7218	784	2	-	-	NOUN
bam-7218	784	3	mail	mail	NOUN
bam-7218	784	4	:	:	PUNCT
bam-7218	784	5	emanuela.agosti@med.uniupo.it	emanuela.agosti@med.uniupo.it	NUM
bam-7218	784	6	cachexia	cachexia	NOUN
bam-7218	784	7	is	be	AUX
bam-7218	784	8	a	a	DET
bam-7218	784	9	metabolic	metabolic	NOUN
bam-7218	784	10	syndrome	syndrome	NOUN
bam-7218	784	11	characterized	characterize	VERB
bam-7218	784	12	by	by	ADP
bam-7218	784	13	an	an	DET
bam-7218	784	14	involuntary	involuntary	ADJ
bam-7218	784	15	loss	loss	NOUN
bam-7218	784	16	of	of	ADP
bam-7218	784	17	skeletal	skeletal	ADJ
bam-7218	784	18	muscle	muscle	NOUN
bam-7218	784	19	and	and	CCONJ
bam-7218	784	20	adipose	adipose	PRON
bam-7218	784	21	tissue	tissue	NOUN
bam-7218	784	22	that	that	PRON
bam-7218	784	23	leads	lead	VERB
bam-7218	784	24	to	to	ADP
bam-7218	784	25	progressive	progressive	ADJ
bam-7218	784	26	functional	functional	ADJ
bam-7218	784	27	impairment	impairment	NOUN
bam-7218	784	28	.	.	PUNCT
bam-7218	785	1	this	this	DET
bam-7218	785	2	syndrome	syndrome	NOUN
bam-7218	785	3	affects	affect	VERB
bam-7218	785	4	about	about	ADV
bam-7218	785	5	50	50	NUM
bam-7218	785	6	-	-	SYM
bam-7218	785	7	80	80	NUM
bam-7218	785	8	%	%	NOUN
bam-7218	785	9	of	of	ADP
bam-7218	785	10	cancer	cancer	NOUN
bam-7218	785	11	patients	patient	NOUN
bam-7218	785	12	and	and	CCONJ
bam-7218	785	13	there	there	PRON
bam-7218	785	14	are	be	VERB
bam-7218	785	15	no	no	DET
bam-7218	785	16	standard	standard	ADJ
bam-7218	785	17	therapy	therapy	NOUN
bam-7218	785	18	regimens	regimen	NOUN
bam-7218	785	19	for	for	ADP
bam-7218	785	20	its	its	PRON
bam-7218	785	21	management	management	NOUN
bam-7218	785	22	.	.	PUNCT
bam-7218	786	1	acylated	acylate	VERB
bam-7218	786	2	and	and	CCONJ
bam-7218	786	3	unacylated	unacylated	ADJ
bam-7218	786	4	ghrelin	ghrelin	NOUN
bam-7218	786	5	(	(	PUNCT
bam-7218	786	6	ag	ag	PROPN
bam-7218	786	7	and	and	CCONJ
bam-7218	786	8	unag	unag	ADJ
bam-7218	786	9	)	)	PUNCT
bam-7218	786	10	are	be	AUX
bam-7218	786	11	circulating	circulate	VERB
bam-7218	786	12	peptide	peptide	ADJ
bam-7218	786	13	hormones	hormone	NOUN
bam-7218	786	14	generated	generate	VERB
bam-7218	786	15	mainly	mainly	ADV
bam-7218	786	16	in	in	ADP
bam-7218	786	17	the	the	DET
bam-7218	786	18	stomach	stomach	NOUN
bam-7218	786	19	due	due	ADP
bam-7218	786	20	to	to	ADP
bam-7218	786	21	fasting	fast	VERB
bam-7218	786	22	or	or	CCONJ
bam-7218	786	23	caloric	caloric	ADJ
bam-7218	786	24	restriction	restriction	NOUN
bam-7218	786	25	.	.	PUNCT
bam-7218	787	1	ag	ag	PROPN
bam-7218	787	2	,	,	PUNCT
bam-7218	787	3	through	through	ADP
bam-7218	787	4	binding	bind	VERB
bam-7218	787	5	to	to	ADP
bam-7218	787	6	ghsr-1a	ghsr-1a	NOUN
bam-7218	787	7	,	,	PUNCT
bam-7218	787	8	induces	induce	VERB
bam-7218	787	9	strong	strong	ADJ
bam-7218	787	10	gh	gh	PROPN
bam-7218	787	11	release	release	PROPN
bam-7218	787	12	,	,	PUNCT
bam-7218	787	13	stimulates	stimulate	VERB
bam-7218	787	14	food	food	NOUN
bam-7218	787	15	intake	intake	NOUN
bam-7218	787	16	,	,	PUNCT
bam-7218	787	17	adiposity	adiposity	NOUN
bam-7218	787	18	,	,	PUNCT
bam-7218	787	19	and	and	CCONJ
bam-7218	787	20	positive	positive	ADJ
bam-7218	787	21	energy	energy	NOUN
bam-7218	787	22	balance	balance	NOUN
bam-7218	787	23	.	.	PUNCT
bam-7218	788	1	acylation	acylation	NOUN
bam-7218	788	2	of	of	ADP
bam-7218	788	3	ghrelin	ghrelin	NOUN
bam-7218	788	4	is	be	AUX
bam-7218	788	5	essential	essential	ADJ
bam-7218	788	6	for	for	ADP
bam-7218	788	7	its	its	PRON
bam-7218	788	8	binding	binding	NOUN
bam-7218	788	9	to	to	ADP
bam-7218	788	10	ghsr-1a	ghsr-1a	NOUN
bam-7218	788	11	,	,	PUNCT
bam-7218	788	12	since	since	SCONJ
bam-7218	788	13	unag	unag	ADJ
bam-7218	788	14	does	do	AUX
bam-7218	788	15	not	not	PART
bam-7218	788	16	activate	activate	VERB
bam-7218	788	17	this	this	DET
bam-7218	788	18	receptor	receptor	NOUN
bam-7218	788	19	.	.	PUNCT
bam-7218	789	1	in	in	ADP
bam-7218	789	2	both	both	DET
bam-7218	789	3	patients	patient	NOUN
bam-7218	789	4	and	and	CCONJ
bam-7218	789	5	animal	animal	NOUN
bam-7218	789	6	models	model	NOUN
bam-7218	789	7	,	,	PUNCT
bam-7218	789	8	ag	ag	PROPN
bam-7218	789	9	ameliorates	ameliorate	VERB
bam-7218	789	10	cachexia	cachexia	NOUN
bam-7218	789	11	induced	induce	VERB
bam-7218	789	12	by	by	ADP
bam-7218	789	13	several	several	ADJ
bam-7218	789	14	pathological	pathological	ADJ
bam-7218	789	15	conditions	condition	NOUN
bam-7218	789	16	in	in	ADP
bam-7218	789	17	a	a	DET
bam-7218	789	18	ghsr	ghsr	NOUN
bam-7218	789	19	-	-	PUNCT
bam-7218	789	20	dependent	dependent	ADJ
bam-7218	789	21	manner	manner	NOUN
bam-7218	789	22	.	.	PUNCT
bam-7218	790	1	however	however	ADV
bam-7218	790	2	,	,	PUNCT
bam-7218	790	3	we	we	PRON
bam-7218	790	4	have	have	AUX
bam-7218	790	5	shown	show	VERB
bam-7218	790	6	that	that	SCONJ
bam-7218	790	7	both	both	DET
bam-7218	790	8	ag	ag	PROPN
bam-7218	790	9	and	and	CCONJ
bam-7218	790	10	unag	unag	VERB
bam-7218	790	11	directly	directly	ADV
bam-7218	790	12	protect	protect	VERB
bam-7218	790	13	skeletal	skeletal	ADJ
bam-7218	790	14	muscle	muscle	NOUN
bam-7218	790	15	from	from	ADP
bam-7218	790	16	experimentallyinduced	experimentallyinduce	VERB
bam-7218	790	17	atrophy	atrophy	NOUN
bam-7218	790	18	,	,	PUNCT
bam-7218	790	19	independently	independently	ADV
bam-7218	790	20	of	of	ADP
bam-7218	790	21	ghsr-1a	ghsr-1a	NOUN
bam-7218	790	22	,	,	PUNCT
bam-7218	790	23	thus	thus	ADV
bam-7218	790	24	providing	provide	VERB
bam-7218	790	25	the	the	DET
bam-7218	790	26	evidence	evidence	NOUN
bam-7218	790	27	for	for	ADP
bam-7218	790	28	the	the	DET
bam-7218	790	29	existence	existence	NOUN
bam-7218	790	30	of	of	ADP
bam-7218	790	31	an	an	DET
bam-7218	790	32	alternative	alternative	ADJ
bam-7218	790	33	ghrelin	ghrelin	NOUN
bam-7218	790	34	receptor	receptor	NOUN
bam-7218	790	35	.	.	PUNCT
bam-7218	791	1	anamorelin	anamorelin	PROPN
bam-7218	791	2	(	(	PUNCT
bam-7218	791	3	anam	anam	PROPN
bam-7218	791	4	)	)	PUNCT
bam-7218	791	5	is	be	AUX
bam-7218	791	6	a	a	DET
bam-7218	791	7	selective	selective	ADJ
bam-7218	791	8	agonist	agonist	NOUN
bam-7218	791	9	of	of	ADP
bam-7218	791	10	ghsr-1a	ghsr-1a	PUNCT
bam-7218	791	11	with	with	ADP
bam-7218	791	12	appetite	appetite	NOUN
bam-7218	791	13	-	-	PUNCT
bam-7218	791	14	enhancing	enhance	VERB
bam-7218	791	15	and	and	CCONJ
bam-7218	791	16	anabolic	anabolic	NOUN
bam-7218	791	17	effects	effect	NOUN
bam-7218	791	18	.	.	PUNCT
bam-7218	792	1	different	different	ADJ
bam-7218	792	2	clinical	clinical	ADJ
bam-7218	792	3	studies	study	NOUN
bam-7218	792	4	have	have	AUX
bam-7218	792	5	highlighted	highlight	VERB
bam-7218	792	6	its	its	PRON
bam-7218	792	7	ability	ability	NOUN
bam-7218	792	8	to	to	PART
bam-7218	792	9	improve	improve	VERB
bam-7218	792	10	the	the	DET
bam-7218	792	11	cachectic	cachectic	ADJ
bam-7218	792	12	state	state	NOUN
bam-7218	792	13	in	in	ADP
bam-7218	792	14	cancer	cancer	NOUN
bam-7218	792	15	patients	patient	NOUN
bam-7218	792	16	by	by	ADP
bam-7218	792	17	increasing	increase	VERB
bam-7218	792	18	total	total	ADJ
bam-7218	792	19	body	body	NOUN
bam-7218	792	20	mass	mass	NOUN
bam-7218	792	21	.	.	PUNCT
bam-7218	793	1	nevertheless	nevertheless	ADV
bam-7218	793	2	,	,	PUNCT
bam-7218	793	3	the	the	DET
bam-7218	793	4	effects	effect	NOUN
bam-7218	793	5	of	of	ADP
bam-7218	793	6	anam	anam	PROPN
bam-7218	793	7	on	on	ADP
bam-7218	793	8	muscle	muscle	NOUN
bam-7218	793	9	tissues	tissue	NOUN
bam-7218	793	10	have	have	AUX
bam-7218	793	11	not	not	PART
bam-7218	793	12	yet	yet	ADV
bam-7218	793	13	been	be	AUX
bam-7218	793	14	completely	completely	ADV
bam-7218	793	15	elucidated	elucidated	ADJ
bam-7218	793	16	.	.	PUNCT
bam-7218	794	1	the	the	DET
bam-7218	794	2	data	data	NOUN
bam-7218	794	3	herein	herein	NOUN
bam-7218	794	4	presented	present	VERB
bam-7218	794	5	show	show	VERB
bam-7218	794	6	that	that	SCONJ
bam-7218	794	7	anam	anam	VERB
bam-7218	794	8	not	not	PART
bam-7218	794	9	only	only	ADV
bam-7218	794	10	binds	bind	VERB
bam-7218	794	11	to	to	ADP
bam-7218	794	12	ghsr-1a	ghsr-1a	NOUN
bam-7218	794	13	,	,	PUNCT
bam-7218	794	14	but	but	CCONJ
bam-7218	794	15	also	also	ADV
bam-7218	794	16	recognizes	recognize	VERB
bam-7218	794	17	the	the	DET
bam-7218	794	18	alternative	alternative	ADJ
bam-7218	794	19	receptor	receptor	NOUN
bam-7218	794	20	responsible	responsible	ADJ
bam-7218	794	21	for	for	ADP
bam-7218	794	22	the	the	DET
bam-7218	794	23	anti	anti	ADJ
bam-7218	794	24	-	-	ADJ
bam-7218	794	25	atrophic	atrophic	ADJ
bam-7218	794	26	activity	activity	NOUN
bam-7218	794	27	shown	show	VERB
bam-7218	794	28	by	by	ADP
bam-7218	794	29	ghrelin	ghrelin	NOUN
bam-7218	794	30	.	.	PUNCT
bam-7218	795	1	indeed	indeed	ADV
bam-7218	795	2	,	,	PUNCT
bam-7218	795	3	anam	anam	PROPN
bam-7218	795	4	protects	protect	VERB
bam-7218	795	5	c2c12	c2c12	PROPN
bam-7218	795	6	myotubes	myotube	NOUN
bam-7218	795	7	from	from	ADP
bam-7218	795	8	experimentally	experimentally	ADV
bam-7218	795	9	-	-	PUNCT
bam-7218	795	10	induced	induce	VERB
bam-7218	795	11	atrophy	atrophy	NOUN
bam-7218	795	12	and	and	CCONJ
bam-7218	795	13	activates	activate	VERB
bam-7218	795	14	protein	protein	NOUN
bam-7218	795	15	synthesis	synthesis	NOUN
bam-7218	795	16	.	.	PUNCT
bam-7218	796	1	these	these	DET
bam-7218	796	2	effects	effect	NOUN
bam-7218	796	3	are	be	AUX
bam-7218	796	4	ghsr-1a	ghsr-1a	ADV
bam-7218	796	5	independent	independent	ADJ
bam-7218	796	6	,	,	PUNCT
bam-7218	796	7	since	since	SCONJ
bam-7218	796	8	they	they	PRON
bam-7218	796	9	are	be	AUX
bam-7218	796	10	also	also	ADV
bam-7218	796	11	visible	visible	ADJ
bam-7218	796	12	in	in	ADP
bam-7218	796	13	culture	culture	NOUN
bam-7218	796	14	of	of	ADP
bam-7218	796	15	primary	primary	ADJ
bam-7218	796	16	myotubes	myotube	NOUN
bam-7218	796	17	obtained	obtain	VERB
bam-7218	796	18	from	from	ADP
bam-7218	796	19	ghsr-1a	ghsr-1a	ADJ
bam-7218	796	20	knock	knock	VERB
bam-7218	796	21	-	-	PUNCT
bam-7218	796	22	out	out	ADP
bam-7218	796	23	mice	mouse	NOUN
bam-7218	796	24	.	.	PUNCT
bam-7218	797	1	p.02	p.02	DET
bam-7218	797	2	glycosylation	glycosylation	NOUN
bam-7218	797	3	stabilizes	stabilize	VERB
bam-7218	797	4	igf-1ea	igf-1ea	NUM
bam-7218	797	5	pro	pro	ADJ
bam-7218	797	6	hormone	hormone	NOUN
bam-7218	797	7	and	and	CCONJ
bam-7218	797	8	regulates	regulate	VERB
bam-7218	797	9	its	its	PRON
bam-7218	797	10	secretion	secretion	NOUN
bam-7218	797	11	giosuè	giosuè	NOUN
bam-7218	797	12	annibalini	annibalini	PROPN
bam-7218	797	13	(	(	PUNCT
bam-7218	797	14	a	a	NOUN
bam-7218	797	15	)	)	PUNCT
bam-7218	797	16	,	,	PUNCT
bam-7218	797	17	mauro	mauro	PROPN
bam-7218	797	18	de	de	PROPN
bam-7218	797	19	santi	santi	PROPN
bam-7218	797	20	(	(	PUNCT
bam-7218	797	21	a	a	PROPN
bam-7218	797	22	)	)	PUNCT
bam-7218	797	23	,	,	PUNCT
bam-7218	797	24	serena	serena	PROPN
bam-7218	797	25	contarelli	contarelli	PROPN
bam-7218	797	26	(	(	PUNCT
bam-7218	797	27	a	a	PROPN
bam-7218	797	28	)	)	PUNCT
bam-7218	797	29	,	,	PUNCT
bam-7218	797	30	roberta	roberta	PROPN
bam-7218	797	31	saltarelli	saltarelli	PROPN
bam-7218	797	32	(	(	PUNCT
bam-7218	797	33	a	a	X
bam-7218	797	34	)	)	PUNCT
bam-7218	797	35	,	,	PUNCT
bam-7218	797	36	michele	michele	PROPN
bam-7218	797	37	guescini	guescini	PROPN
bam-7218	797	38	(	(	PUNCT
bam-7218	797	39	a	a	NOUN
bam-7218	797	40	)	)	PUNCT
bam-7218	797	41	,	,	PUNCT
bam-7218	797	42	luciana	luciana	PROPN
bam-7218	797	43	vallorani	vallorani	PROPN
bam-7218	797	44	(	(	PUNCT
bam-7218	797	45	a	a	PROPN
bam-7218	797	46	)	)	PUNCT
bam-7218	797	47	,	,	PUNCT
bam-7218	797	48	giorgio	giorgio	PROPN
bam-7218	797	49	brandi	brandi	PROPN
bam-7218	797	50	(	(	PUNCT
bam-7218	797	51	a	a	NOUN
bam-7218	797	52	)	)	PUNCT
bam-7218	797	53	,	,	PUNCT
bam-7218	797	54	vilberto	vilberto	PROPN
bam-7218	797	55	stocchi	stocchi	PROPN
bam-7218	797	56	(	(	PUNCT
bam-7218	797	57	a	a	X
bam-7218	797	58	)	)	PUNCT
bam-7218	797	59	,	,	PUNCT
bam-7218	797	60	elena	elena	PROPN
bam-7218	797	61	barbieri	barbieri	PROPN
bam-7218	797	62	(	(	PUNCT
bam-7218	797	63	a	a	DET
bam-7218	797	64	,	,	PUNCT
bam-7218	797	65	b	b	NOUN
bam-7218	797	66	)	)	PUNCT
bam-7218	797	67	(	(	PUNCT
bam-7218	797	68	a	a	X
bam-7218	797	69	)	)	PUNCT
bam-7218	797	70	dept	dept	NOUN
bam-7218	797	71	of	of	ADP
bam-7218	797	72	biomolecular	biomolecular	ADJ
bam-7218	797	73	sciences	science	NOUN
bam-7218	797	74	,	,	PUNCT
bam-7218	797	75	university	university	NOUN
bam-7218	797	76	of	of	ADP
bam-7218	797	77	urbino	urbino	PROPN
bam-7218	797	78	carlo	carlo	PROPN
bam-7218	797	79	bo	bo	PROPN
bam-7218	797	80	,	,	PUNCT
bam-7218	797	81	61029	61029	NUM
bam-7218	797	82	urbino	urbino	NOUN
bam-7218	797	83	,	,	PUNCT
bam-7218	797	84	italy	italy	PROPN
bam-7218	797	85	;	;	PUNCT
bam-7218	797	86	(	(	PUNCT
bam-7218	797	87	b	b	X
bam-7218	797	88	)	)	PUNCT
bam-7218	797	89	interuniversity	interuniversity	NOUN
bam-7218	797	90	institute	institute	PROPN
bam-7218	797	91	of	of	ADP
bam-7218	797	92	myology	myology	NOUN
bam-7218	797	93	,	,	PUNCT
bam-7218	797	94	urbino	urbino	PROPN
bam-7218	797	95	,	,	PUNCT
bam-7218	797	96	italy	italy	PROPN
bam-7218	797	97	.	.	PUNCT
bam-7218	798	1	e	e	X
bam-7218	798	2	-	-	NOUN
bam-7218	798	3	mail	mail	NOUN
bam-7218	798	4	:	:	PUNCT
bam-7218	798	5	giosue.annibalini@uniurb.it	giosue.annibalini@uniurb.it	VERB
bam-7218	798	6	198	198	NUM
bam-7218	798	7	insulin	insulin	NOUN
bam-7218	798	8	-	-	PUNCT
bam-7218	798	9	like	like	ADJ
bam-7218	798	10	growth	growth	NOUN
bam-7218	798	11	factor-1	factor-1	PROPN
bam-7218	798	12	(	(	PUNCT
bam-7218	798	13	igf-1	igf-1	NOUN
bam-7218	798	14	)	)	PUNCT
bam-7218	798	15	is	be	AUX
bam-7218	798	16	a	a	DET
bam-7218	798	17	growth	growth	NOUN
bam-7218	798	18	factor	factor	NOUN
bam-7218	798	19	with	with	ADP
bam-7218	798	20	multiple	multiple	ADJ
bam-7218	798	21	roles	role	NOUN
bam-7218	798	22	in	in	ADP
bam-7218	798	23	various	various	ADJ
bam-7218	798	24	aspects	aspect	NOUN
bam-7218	798	25	of	of	ADP
bam-7218	798	26	normal	normal	ADJ
bam-7218	798	27	and	and	CCONJ
bam-7218	798	28	pathological	pathological	ADJ
bam-7218	798	29	growth	growth	NOUN
bam-7218	798	30	and	and	CCONJ
bam-7218	798	31	differentiation	differentiation	NOUN
bam-7218	798	32	.	.	PUNCT
bam-7218	799	1	the	the	DET
bam-7218	799	2	translation	translation	NOUN
bam-7218	799	3	of	of	ADP
bam-7218	799	4	the	the	DET
bam-7218	799	5	igf-1	igf-1	NUM
bam-7218	799	6	gene	gene	NOUN
bam-7218	799	7	gives	give	VERB
bam-7218	799	8	rise	rise	NOUN
bam-7218	799	9	to	to	ADP
bam-7218	799	10	an	an	DET
bam-7218	799	11	immature	immature	ADJ
bam-7218	799	12	igf-1	igf-1	NOUN
bam-7218	799	13	peptide	peptide	NOUN
bam-7218	799	14	,	,	PUNCT
bam-7218	799	15	which	which	PRON
bam-7218	799	16	has	have	VERB
bam-7218	799	17	a	a	DET
bam-7218	799	18	signal	signal	ADJ
bam-7218	799	19	peptide	peptide	NOUN
bam-7218	799	20	at	at	ADP
bam-7218	799	21	the	the	DET
bam-7218	799	22	5	5	NUM
bam-7218	799	23	’	'	PUNCT
bam-7218	799	24	end	end	NOUN
bam-7218	799	25	of	of	ADP
bam-7218	799	26	the	the	DET
bam-7218	799	27	gene	gene	NOUN
bam-7218	799	28	,	,	PUNCT
bam-7218	799	29	a	a	DET
bam-7218	799	30	core	core	NOUN
bam-7218	799	31	region	region	NOUN
bam-7218	799	32	and	and	CCONJ
bam-7218	799	33	an	an	DET
bam-7218	799	34	ea	ea	NOUN
bam-7218	799	35	-	-	NOUN
bam-7218	799	36	peptide	peptide	NOUN
bam-7218	799	37	at	at	ADP
bam-7218	799	38	the	the	DET
bam-7218	799	39	3	3	NUM
bam-7218	799	40	’	'	PUNCT
bam-7218	799	41	end	end	NOUN
bam-7218	799	42	.	.	PUNCT
bam-7218	800	1	the	the	DET
bam-7218	800	2	signal	signal	ADJ
bam-7218	800	3	peptide	peptide	NOUN
bam-7218	800	4	is	be	AUX
bam-7218	800	5	removed	remove	VERB
bam-7218	800	6	after	after	ADP
bam-7218	800	7	facilitating	facilitate	VERB
bam-7218	800	8	the	the	DET
bam-7218	800	9	passage	passage	NOUN
bam-7218	800	10	of	of	ADP
bam-7218	800	11	the	the	DET
bam-7218	800	12	polypeptide	polypeptide	NOUN
bam-7218	800	13	into	into	ADP
bam-7218	800	14	the	the	DET
bam-7218	800	15	endoplasmic	endoplasmic	ADJ
bam-7218	800	16	reticulum	reticulum	NOUN
bam-7218	800	17	and	and	CCONJ
bam-7218	800	18	give	give	VERB
bam-7218	800	19	rise	rise	NOUN
bam-7218	800	20	to	to	ADP
bam-7218	800	21	the	the	DET
bam-7218	800	22	igf-1	igf-1	NOUN
bam-7218	800	23	prohormone	prohormone	NOUN
bam-7218	800	24	(	(	PUNCT
bam-7218	800	25	proigf-1ea	proigf-1ea	NOUN
bam-7218	800	26	)	)	PUNCT
bam-7218	800	27	,	,	PUNCT
bam-7218	800	28	retaining	retain	VERB
bam-7218	800	29	c	c	NOUN
bam-7218	800	30	-	-	PUNCT
bam-7218	800	31	terminal	terminal	ADJ
bam-7218	800	32	ea	ea	NOUN
bam-7218	800	33	peptide	peptide	NOUN
bam-7218	800	34	.	.	PUNCT
bam-7218	801	1	recent	recent	ADJ
bam-7218	801	2	studies	study	NOUN
bam-7218	801	3	demonstrated	demonstrate	VERB
bam-7218	801	4	that	that	SCONJ
bam-7218	801	5	intracellular	intracellular	NOUN
bam-7218	801	6	igf-1	igf-1	NOUN
bam-7218	801	7	is	be	AUX
bam-7218	801	8	mainly	mainly	ADV
bam-7218	801	9	mailto:hana.sustova@med.uniupo.it	mailto:hana.sustova@med.uniupo.it	X
bam-7218	801	10	mailto:emanuela.agosti@med.uniupo.it	mailto:emanuela.agosti@med.uniupo.it	NOUN
bam-7218	801	11	mailto:giosue.annibalini@uniurb.it	mailto:giosue.annibalini@uniurb.it	PROPN
bam-7218	801	12	14	14	NUM
bam-7218	801	13	th	th	NOUN
bam-7218	801	14	iiim	iiim	NOUN
bam-7218	801	15	meeting	meeting	NOUN
bam-7218	801	16	,	,	PUNCT
bam-7218	801	17	assisi	assisi	PROPN
bam-7218	801	18	,	,	PUNCT
bam-7218	801	19	italy	italy	PROPN
bam-7218	801	20	october	october	PROPN
bam-7218	801	21	12	12	NUM
bam-7218	801	22	-	-	SYM
bam-7218	801	23	15	15	NUM
bam-7218	801	24	2017	2017	NUM
bam-7218	801	25	eur	eur	PROPN
bam-7218	801	26	j	j	PROPN
bam-7218	801	27	transl	transl	PROPN
bam-7218	801	28	myol	myol	ADV
bam-7218	801	29	27	27	NUM
bam-7218	801	30	(	(	PUNCT
bam-7218	801	31	4	4	NUM
bam-7218	801	32	):	):	SYM
bam-7218	801	33	185	185	NUM
bam-7218	801	34	-	-	SYM
bam-7218	801	35	224	224	NUM
bam-7218	801	36	209	209	NUM
bam-7218	801	37	expressed	express	VERB
bam-7218	801	38	as	as	ADP
bam-7218	801	39	prohormone	prohormone	NOUN
bam-7218	801	40	,	,	PUNCT
bam-7218	801	41	not	not	PART
bam-7218	801	42	mature	mature	VERB
bam-7218	801	43	igf-1	igf-1	NOUN
bam-7218	801	44	.	.	PUNCT
bam-7218	802	1	moreover	moreover	ADV
bam-7218	802	2	,	,	PUNCT
bam-7218	802	3	we	we	PRON
bam-7218	802	4	recently	recently	ADV
bam-7218	802	5	demonstrated	demonstrate	VERB
bam-7218	802	6	that	that	SCONJ
bam-7218	802	7	the	the	DET
bam-7218	802	8	ea	ea	PROPN
bam-7218	802	9	peptide	peptide	NOUN
bam-7218	802	10	is	be	AUX
bam-7218	802	11	an	an	DET
bam-7218	802	12	intrinsically	intrinsically	ADV
bam-7218	802	13	disordered	disordered	ADJ
bam-7218	802	14	region	region	NOUN
bam-7218	802	15	(	(	PUNCT
bam-7218	802	16	idr	idr	PROPN
bam-7218	802	17	)	)	PUNCT
bam-7218	802	18	enriched	enrich	VERB
bam-7218	802	19	in	in	ADP
bam-7218	802	20	regulatory	regulatory	ADJ
bam-7218	802	21	elements	element	NOUN
bam-7218	802	22	including	include	VERB
bam-7218	802	23	a	a	DET
bam-7218	802	24	highly	highly	ADV
bam-7218	802	25	conserved	conserve	VERB
bam-7218	802	26	nglycoylation	nglycoylation	NOUN
bam-7218	802	27	site	site	NOUN
bam-7218	802	28	.	.	PUNCT
bam-7218	803	1	in	in	ADP
bam-7218	803	2	this	this	DET
bam-7218	803	3	study	study	NOUN
bam-7218	803	4	we	we	PRON
bam-7218	803	5	investigate	investigate	VERB
bam-7218	803	6	the	the	DET
bam-7218	803	7	role	role	NOUN
bam-7218	803	8	of	of	ADP
bam-7218	803	9	ea	ea	X
bam-7218	803	10	peptide	peptide	NOUN
bam-7218	803	11	glycosylation	glycosylation	NOUN
bam-7218	803	12	on	on	ADP
bam-7218	803	13	proigf-1ea	proigf-1ea	ADJ
bam-7218	803	14	stability	stability	NOUN
bam-7218	803	15	and	and	CCONJ
bam-7218	803	16	secretion	secretion	NOUN
bam-7218	803	17	.	.	PUNCT
bam-7218	804	1	after	after	SCONJ
bam-7218	804	2	transient	transient	ADJ
bam-7218	804	3	transfection	transfection	NOUN
bam-7218	804	4	of	of	ADP
bam-7218	804	5	hek293	hek293	PROPN
bam-7218	804	6	cells	cell	NOUN
bam-7218	804	7	with	with	ADP
bam-7218	804	8	igf-1ea	igf-1ea	NUM
bam-7218	804	9	transgene	transgene	VERB
bam-7218	804	10	two	two	NUM
bam-7218	804	11	igf-1	igf-1	NOUN
bam-7218	804	12	prohormones	prohormone	NOUN
bam-7218	804	13	were	be	AUX
bam-7218	804	14	produced	produce	VERB
bam-7218	804	15	intracellularly	intracellularly	ADV
bam-7218	804	16	:	:	PUNCT
bam-7218	804	17	glycosylated	glycosylated	ADJ
bam-7218	804	18	(	(	PUNCT
bam-7218	804	19	~17kda	~17kda	NOUN
bam-7218	804	20	)	)	PUNCT
bam-7218	804	21	and	and	CCONJ
bam-7218	804	22	non	non	ADJ
bam-7218	804	23	-	-	ADJ
bam-7218	804	24	glycosylated	glycosylated	ADJ
bam-7218	804	25	forms	form	NOUN
bam-7218	804	26	(	(	PUNCT
bam-7218	804	27	~11	~11	NOUN
bam-7218	804	28	-	-	NOUN
bam-7218	804	29	12kda	12kda	NOUN
bam-7218	804	30	)	)	PUNCT
bam-7218	804	31	.	.	PUNCT
bam-7218	805	1	subsequently	subsequently	ADV
bam-7218	805	2	,	,	PUNCT
bam-7218	805	3	we	we	PRON
bam-7218	805	4	wondered	wonder	VERB
bam-7218	805	5	whether	whether	SCONJ
bam-7218	805	6	glucose	glucose	NOUN
bam-7218	805	7	withdrawal	withdrawal	NOUN
bam-7218	805	8	or	or	CCONJ
bam-7218	805	9	direct	direct	ADJ
bam-7218	805	10	inhibition	inhibition	NOUN
bam-7218	805	11	of	of	ADP
bam-7218	805	12	n	n	NOUN
bam-7218	805	13	-	-	PUNCT
bam-7218	805	14	glycosylation	glycosylation	NOUN
bam-7218	805	15	by	by	ADP
bam-7218	805	16	tunicamycin	tunicamycin	PROPN
bam-7218	805	17	(	(	PUNCT
bam-7218	805	18	tun	tun	NOUN
bam-7218	805	19	)	)	PUNCT
bam-7218	805	20	might	might	AUX
bam-7218	805	21	interfere	interfere	VERB
bam-7218	805	22	with	with	ADP
bam-7218	805	23	igf-1ea	igf-1ea	NOUN
bam-7218	805	24	production	production	NOUN
bam-7218	805	25	.	.	PUNCT
bam-7218	806	1	to	to	PART
bam-7218	806	2	achieve	achieve	VERB
bam-7218	806	3	this	this	DET
bam-7218	806	4	aim	aim	NOUN
bam-7218	806	5	,	,	PUNCT
bam-7218	806	6	we	we	PRON
bam-7218	806	7	overexpressed	overexpresse	VERB
bam-7218	806	8	proigf-1ea	proigf-1ea	NOUN
bam-7218	806	9	in	in	ADP
bam-7218	806	10	hek293	hek293	PROPN
bam-7218	806	11	cells	cell	NOUN
bam-7218	806	12	cultured	cultured	ADJ
bam-7218	806	13	in	in	ADP
bam-7218	806	14	glucose	glucose	NOUN
bam-7218	806	15	depleted	deplete	VERB
bam-7218	806	16	medium	medium	NOUN
bam-7218	806	17	or	or	CCONJ
bam-7218	806	18	treated	treat	VERB
bam-7218	806	19	with	with	ADP
bam-7218	806	20	tun	tun	PROPN
bam-7218	806	21	.	.	PUNCT
bam-7218	807	1	notably	notably	ADV
bam-7218	807	2	,	,	PUNCT
bam-7218	807	3	the	the	DET
bam-7218	807	4	band	band	NOUN
bam-7218	807	5	corresponding	correspond	VERB
bam-7218	807	6	to	to	ADP
bam-7218	807	7	glycosylated	glycosylated	ADJ
bam-7218	807	8	proigf-1ea	proigf-1ea	NOUN
bam-7218	807	9	completely	completely	ADV
bam-7218	807	10	disappeared	disappear	VERB
bam-7218	807	11	in	in	ADP
bam-7218	807	12	the	the	DET
bam-7218	807	13	absence	absence	NOUN
bam-7218	807	14	of	of	ADP
bam-7218	807	15	glucose	glucose	NOUN
bam-7218	807	16	or	or	CCONJ
bam-7218	807	17	after	after	ADP
bam-7218	807	18	treatment	treatment	NOUN
bam-7218	807	19	with	with	ADP
bam-7218	807	20	tun	tun	PROPN
bam-7218	807	21	.	.	PUNCT
bam-7218	808	1	moreover	moreover	ADV
bam-7218	808	2	,	,	PUNCT
bam-7218	808	3	the	the	DET
bam-7218	808	4	analysis	analysis	NOUN
bam-7218	808	5	of	of	ADP
bam-7218	808	6	culture	culture	NOUN
bam-7218	808	7	media	medium	NOUN
bam-7218	808	8	of	of	ADP
bam-7218	808	9	igf-1ea	igf-1ea	NOUN
bam-7218	808	10	-	-	PUNCT
bam-7218	808	11	transfected	transfecte	VERB
bam-7218	808	12	hek293	hek293	PROPN
bam-7218	808	13	cells	cell	NOUN
bam-7218	808	14	showed	show	VERB
bam-7218	808	15	that	that	SCONJ
bam-7218	808	16	the	the	DET
bam-7218	808	17	inhibition	inhibition	NOUN
bam-7218	808	18	of	of	ADP
bam-7218	808	19	glycosylation	glycosylation	NOUN
bam-7218	808	20	by	by	ADP
bam-7218	808	21	glucose	glucose	NOUN
bam-7218	808	22	deprivation	deprivation	NOUN
bam-7218	808	23	or	or	CCONJ
bam-7218	808	24	tun	tun	NOUN
bam-7218	808	25	completely	completely	ADV
bam-7218	808	26	abrogated	abrogate	VERB
bam-7218	808	27	the	the	DET
bam-7218	808	28	glycosylated	glycosylate	VERB
bam-7218	808	29	proigf-1ea	proigf-1ea	NOUN
bam-7218	808	30	secretion	secretion	NOUN
bam-7218	808	31	and	and	CCONJ
bam-7218	808	32	markedly	markedly	ADV
bam-7218	808	33	reduced	reduce	VERB
bam-7218	808	34	the	the	DET
bam-7218	808	35	mature	mature	ADJ
bam-7218	808	36	igf-1	igf-1	NOUN
bam-7218	808	37	secretion	secretion	NOUN
bam-7218	808	38	.	.	PUNCT
bam-7218	809	1	after	after	ADP
bam-7218	809	2	that	that	PRON
bam-7218	809	3	,	,	PUNCT
bam-7218	809	4	using	use	VERB
bam-7218	809	5	the	the	DET
bam-7218	809	6	protein	protein	NOUN
bam-7218	809	7	synthesis	synthesis	NOUN
bam-7218	809	8	inhibitor	inhibitor	NOUN
bam-7218	809	9	cycloheximide	cycloheximide	NOUN
bam-7218	809	10	,	,	PUNCT
bam-7218	809	11	we	we	PRON
bam-7218	809	12	demonstrated	demonstrate	VERB
bam-7218	809	13	that	that	SCONJ
bam-7218	809	14	the	the	DET
bam-7218	809	15	turnover	turnover	NOUN
bam-7218	809	16	rate	rate	NOUN
bam-7218	809	17	for	for	ADP
bam-7218	809	18	non	non	ADJ
bam-7218	809	19	-	-	ADJ
bam-7218	809	20	glycosylated	glycosylated	ADJ
bam-7218	809	21	igf-1ea	igf-1ea	NOUN
bam-7218	809	22	was	be	AUX
bam-7218	809	23	faster	fast	ADJ
bam-7218	809	24	than	than	ADP
bam-7218	809	25	glycosylated	glycosylated	ADJ
bam-7218	809	26	igf-1ea	igf-1ea	NOUN
bam-7218	809	27	.	.	PUNCT
bam-7218	810	1	to	to	PART
bam-7218	810	2	test	test	VERB
bam-7218	810	3	the	the	DET
bam-7218	810	4	involvement	involvement	NOUN
bam-7218	810	5	of	of	ADP
bam-7218	810	6	26s	26s	PROPN
bam-7218	810	7	proteasome	proteasome	NOUN
bam-7218	810	8	machinery	machinery	NOUN
bam-7218	810	9	,	,	PUNCT
bam-7218	810	10	we	we	PRON
bam-7218	810	11	subsequently	subsequently	ADV
bam-7218	810	12	treated	treat	VERB
bam-7218	810	13	igf-1ea	igf-1ea	NOUN
bam-7218	810	14	-	-	PUNCT
bam-7218	810	15	transfected	transfecte	VERB
bam-7218	810	16	hek293	hek293	PROPN
bam-7218	810	17	cells	cell	NOUN
bam-7218	810	18	with	with	ADP
bam-7218	810	19	proteasome	proteasome	NOUN
bam-7218	810	20	inhibitor	inhibitor	NOUN
bam-7218	810	21	mg132	mg132	PROPN
bam-7218	811	1	and	and	CCONJ
bam-7218	811	2	we	we	PRON
bam-7218	811	3	found	find	VERB
bam-7218	811	4	an	an	DET
bam-7218	811	5	increase	increase	NOUN
bam-7218	811	6	of	of	ADP
bam-7218	811	7	non	non	ADJ
bam-7218	811	8	-	-	ADJ
bam-7218	811	9	glycosylated	glycosylated	ADJ
bam-7218	811	10	igf-1ea	igf-1ea	NOUN
bam-7218	811	11	,	,	PUNCT
bam-7218	811	12	while	while	SCONJ
bam-7218	811	13	igf-1ea	igf-1ea	NOUN
bam-7218	811	14	glycosylated	glycosylate	VERB
bam-7218	811	15	was	be	AUX
bam-7218	811	16	marginally	marginally	ADV
bam-7218	811	17	affected	affect	VERB
bam-7218	811	18	by	by	ADP
bam-7218	811	19	proteasome	proteasome	NOUN
bam-7218	811	20	inhibitor	inhibitor	NOUN
bam-7218	811	21	.	.	PUNCT
bam-7218	812	1	in	in	ADP
bam-7218	812	2	conclusion	conclusion	NOUN
bam-7218	812	3	,	,	PUNCT
bam-7218	812	4	these	these	DET
bam-7218	812	5	results	result	NOUN
bam-7218	812	6	show	show	VERB
bam-7218	812	7	that	that	SCONJ
bam-7218	812	8	glycosylation	glycosylation	NOUN
bam-7218	812	9	of	of	ADP
bam-7218	812	10	ea	ea	NOUN
bam-7218	812	11	peptide	peptide	NOUN
bam-7218	812	12	enhances	enhance	VERB
bam-7218	812	13	the	the	DET
bam-7218	812	14	export	export	NOUN
bam-7218	812	15	efficiency	efficiency	NOUN
bam-7218	812	16	of	of	ADP
bam-7218	812	17	proigf-1ea	proigf-1ea	NOUN
bam-7218	813	1	and	and	CCONJ
bam-7218	813	2	it	it	PRON
bam-7218	813	3	is	be	AUX
bam-7218	813	4	necessary	necessary	ADJ
bam-7218	813	5	for	for	ADP
bam-7218	813	6	igf-1	igf-1	NOUN
bam-7218	813	7	secretion	secretion	NOUN
bam-7218	813	8	.	.	PUNCT
bam-7218	814	1	we	we	PRON
bam-7218	814	2	hypothesize	hypothesize	VERB
bam-7218	814	3	that	that	SCONJ
bam-7218	814	4	proigf-1ea	proigf-1ea	NOUN
bam-7218	814	5	glycosylation	glycosylation	NOUN
bam-7218	814	6	ensures	ensure	VERB
bam-7218	814	7	proper	proper	ADJ
bam-7218	814	8	prohormone	prohormone	NOUN
bam-7218	814	9	folding	folding	NOUN
bam-7218	814	10	and	and	CCONJ
bam-7218	814	11	secretion	secretion	NOUN
bam-7218	814	12	preventing	prevent	VERB
bam-7218	814	13	its	its	PRON
bam-7218	814	14	entry	entry	NOUN
bam-7218	814	15	into	into	ADP
bam-7218	814	16	the	the	DET
bam-7218	814	17	er	er	ADV
bam-7218	814	18	-	-	PUNCT
bam-7218	814	19	associated	associate	VERB
bam-7218	814	20	degradation	degradation	NOUN
bam-7218	814	21	(	(	PUNCT
bam-7218	814	22	erad	erad	ADJ
bam-7218	814	23	)	)	PUNCT
bam-7218	814	24	pathway	pathway	NOUN
bam-7218	814	25	.	.	PUNCT
bam-7218	815	1	p.03	p.03	ADJ
bam-7218	815	2	2d	2d	NUM
bam-7218	815	3	and	and	CCONJ
bam-7218	815	4	3d	3d	NUM
bam-7218	815	5	disease	disease	NOUN
bam-7218	815	6	modeling	modeling	NOUN
bam-7218	815	7	of	of	ADP
bam-7218	815	8	becker	becker	PROPN
bam-7218	815	9	and	and	CCONJ
bam-7218	815	10	duchenne	duchenne	PROPN
bam-7218	815	11	’s	’s	PART
bam-7218	815	12	muscular	muscular	ADJ
bam-7218	815	13	dystrophies	dystrophy	NOUN
bam-7218	815	14	jamshid	jamshid	VERB
bam-7218	815	15	arjomand	arjomand	ADV
bam-7218	815	16	(	(	PUNCT
bam-7218	815	17	a	a	X
bam-7218	815	18	)	)	PUNCT
bam-7218	815	19	,	,	PUNCT
bam-7218	815	20	amanda	amanda	PROPN
bam-7218	815	21	rickard	rickard	PROPN
bam-7218	815	22	(	(	PUNCT
bam-7218	815	23	a	a	NOUN
bam-7218	815	24	)	)	PUNCT
bam-7218	815	25	,	,	PUNCT
bam-7218	815	26	lingjun	lingjun	PROPN
bam-7218	815	27	rao	rao	PROPN
bam-7218	815	28	(	(	PUNCT
bam-7218	815	29	b	b	NOUN
bam-7218	815	30	)	)	PUNCT
bam-7218	815	31	,	,	PUNCT
bam-7218	815	32	nenad	nenad	PROPN
bam-7218	815	33	bursac	bursac	NOUN
bam-7218	815	34	(	(	PUNCT
bam-7218	815	35	b	b	NOUN
bam-7218	815	36	)	)	PUNCT
bam-7218	815	37	,	,	PUNCT
bam-7218	815	38	uli	uli	PROPN
bam-7218	815	39	schmidt	schmidt	PROPN
bam-7218	815	40	(	(	PUNCT
bam-7218	815	41	a	a	NOUN
bam-7218	815	42	)	)	PUNCT
bam-7218	815	43	(	(	PUNCT
bam-7218	815	44	a	a	X
bam-7218	815	45	)	)	PUNCT
bam-7218	815	46	genea	genea	NOUN
bam-7218	815	47	biocells	biocell	VERB
bam-7218	815	48	us	us	PROPN
bam-7218	815	49	inc	inc	PROPN
bam-7218	815	50	,	,	PUNCT
bam-7218	815	51	san	san	PROPN
bam-7218	815	52	diego	diego	PROPN
bam-7218	815	53	,	,	PUNCT
bam-7218	815	54	ca	ca	PROPN
bam-7218	815	55	,	,	PUNCT
bam-7218	815	56	usa	usa	PROPN
bam-7218	815	57	;	;	PUNCT
bam-7218	815	58	(	(	PUNCT
bam-7218	815	59	b	b	X
bam-7218	815	60	)	)	PUNCT
bam-7218	815	61	dept	dept	ADJ
bam-7218	815	62	biomedical	biomedical	ADJ
bam-7218	815	63	engineering	engineering	NOUN
bam-7218	815	64	,	,	PUNCT
bam-7218	815	65	duke	duke	PROPN
bam-7218	815	66	university	university	PROPN
bam-7218	815	67	,	,	PUNCT
bam-7218	815	68	durham	durham	PROPN
bam-7218	815	69	,	,	PUNCT
bam-7218	815	70	nc	nc	PROPN
bam-7218	815	71	,	,	PUNCT
bam-7218	815	72	usa	usa	PROPN
bam-7218	815	73	.	.	PROPN
bam-7218	816	1	e	e	X
bam-7218	816	2	-	-	NOUN
bam-7218	816	3	mail	mail	NOUN
bam-7218	816	4	:	:	PUNCT
bam-7218	816	5	jamshid.arjomand@geneabiocells.com	jamshid.arjomand@geneabiocells.com	X
bam-7218	816	6	duchenne	duchenne	NOUN
bam-7218	816	7	and	and	CCONJ
bam-7218	816	8	becker	becker	PROPN
bam-7218	816	9	muscular	muscular	ADJ
bam-7218	816	10	dystrophies	dystrophy	NOUN
bam-7218	816	11	(	(	PUNCT
bam-7218	816	12	d	d	X
bam-7218	816	13	/	/	SYM
bam-7218	816	14	bmd	bmd	PROPN
bam-7218	816	15	)	)	PUNCT
bam-7218	817	1	are	be	AUX
bam-7218	817	2	caused	cause	VERB
bam-7218	817	3	by	by	ADP
bam-7218	817	4	a	a	DET
bam-7218	817	5	variety	variety	NOUN
bam-7218	817	6	of	of	ADP
bam-7218	817	7	mutations	mutation	NOUN
bam-7218	817	8	in	in	ADP
bam-7218	817	9	the	the	DET
bam-7218	817	10	dystrophin	dystrophin	ADJ
bam-7218	817	11	gene	gene	NOUN
bam-7218	817	12	and	and	CCONJ
bam-7218	817	13	collectively	collectively	ADV
bam-7218	817	14	comprise	comprise	VERB
bam-7218	817	15	the	the	DET
bam-7218	817	16	most	most	ADV
bam-7218	817	17	prevalent	prevalent	ADJ
bam-7218	817	18	congenital	congenital	ADJ
bam-7218	817	19	skeletal	skeletal	ADJ
bam-7218	817	20	muscle	muscle	NOUN
bam-7218	817	21	disorders	disorder	NOUN
bam-7218	817	22	.	.	PUNCT
bam-7218	818	1	although	although	SCONJ
bam-7218	818	2	a	a	DET
bam-7218	818	3	recent	recent	ADJ
bam-7218	818	4	therapeutic	therapeutic	ADJ
bam-7218	818	5	treatment	treatment	NOUN
bam-7218	818	6	has	have	AUX
bam-7218	818	7	been	be	AUX
bam-7218	818	8	approved	approve	VERB
bam-7218	818	9	by	by	ADP
bam-7218	818	10	the	the	DET
bam-7218	818	11	fda	fda	PROPN
bam-7218	818	12	,	,	PUNCT
bam-7218	818	13	long	long	ADJ
bam-7218	818	14	term	term	NOUN
bam-7218	818	15	therapeutic	therapeutic	ADJ
bam-7218	818	16	benefits	benefit	NOUN
bam-7218	818	17	are	be	AUX
bam-7218	818	18	pending	pende	VERB
bam-7218	818	19	and	and	CCONJ
bam-7218	818	20	subpopulations	subpopulation	NOUN
bam-7218	818	21	of	of	ADP
bam-7218	818	22	d	d	PROPN
bam-7218	818	23	/	/	SYM
bam-7218	818	24	bmd	bmd	PROPN
bam-7218	818	25	patients	patient	NOUN
bam-7218	818	26	do	do	AUX
bam-7218	818	27	not	not	PART
bam-7218	818	28	benefit	benefit	VERB
bam-7218	818	29	from	from	ADP
bam-7218	818	30	it	it	PRON
bam-7218	818	31	.	.	PUNCT
bam-7218	819	1	drug	drug	NOUN
bam-7218	819	2	discovery	discovery	PROPN
bam-7218	819	3	in	in	ADP
bam-7218	819	4	d	d	PROPN
bam-7218	819	5	/	/	SYM
bam-7218	819	6	bmd	bmd	PROPN
bam-7218	819	7	,	,	PUNCT
bam-7218	819	8	as	as	ADV
bam-7218	819	9	well	well	ADV
bam-7218	819	10	as	as	ADP
bam-7218	819	11	other	other	ADJ
bam-7218	819	12	orphan	orphan	NOUN
bam-7218	819	13	disorders	disorder	NOUN
bam-7218	819	14	,	,	PUNCT
bam-7218	819	15	is	be	AUX
bam-7218	819	16	typically	typically	ADV
bam-7218	819	17	hampered	hamper	VERB
bam-7218	819	18	by	by	ADP
bam-7218	819	19	the	the	DET
bam-7218	819	20	lack	lack	NOUN
bam-7218	819	21	of	of	ADP
bam-7218	819	22	adequate	adequate	ADJ
bam-7218	819	23	disease	disease	NOUN
bam-7218	819	24	models	model	NOUN
bam-7218	819	25	,	,	PUNCT
bam-7218	819	26	clinically	clinically	ADV
bam-7218	819	27	irrelevant	irrelevant	ADJ
bam-7218	819	28	assays	assay	NOUN
bam-7218	819	29	or	or	CCONJ
bam-7218	819	30	a	a	DET
bam-7218	819	31	combination	combination	NOUN
bam-7218	819	32	of	of	ADP
bam-7218	819	33	both	both	PRON
bam-7218	819	34	.	.	PUNCT
bam-7218	820	1	herein	herein	NOUN
bam-7218	820	2	,	,	PUNCT
bam-7218	820	3	we	we	PRON
bam-7218	820	4	present	present	VERB
bam-7218	820	5	a	a	DET
bam-7218	820	6	human	human	ADJ
bam-7218	820	7	pluripotent	pluripotent	NOUN
bam-7218	820	8	stem	stem	NOUN
bam-7218	820	9	cell	cell	NOUN
bam-7218	820	10	(	(	PUNCT
bam-7218	820	11	hpsc	hpsc	NOUN
bam-7218	820	12	)	)	PUNCT
bam-7218	820	13	derived	derive	VERB
bam-7218	820	14	twoand	twoand	ADP
bam-7218	820	15	threedimensional	threedimensional	NOUN
bam-7218	820	16	(	(	PUNCT
bam-7218	820	17	2d	2d	NUM
bam-7218	820	18	and	and	CCONJ
bam-7218	820	19	3d	3d	NUM
bam-7218	820	20	)	)	PUNCT
bam-7218	821	1	d	d	X
bam-7218	821	2	/	/	SYM
bam-7218	821	3	bmd	bmd	PROPN
bam-7218	821	4	disease	disease	PROPN
bam-7218	821	5	modeling	model	VERB
bam-7218	821	6	platform	platform	NOUN
bam-7218	821	7	,	,	PUNCT
bam-7218	821	8	amenable	amenable	ADJ
bam-7218	821	9	to	to	PART
bam-7218	821	10	use	use	VERB
bam-7218	821	11	with	with	ADP
bam-7218	821	12	hpscs	hpscs	NOUN
bam-7218	821	13	carrying	carry	VERB
bam-7218	821	14	any	any	DET
bam-7218	821	15	type	type	NOUN
bam-7218	821	16	of	of	ADP
bam-7218	821	17	dystrophin	dystrophin	ADJ
bam-7218	821	18	mutations	mutation	NOUN
bam-7218	821	19	.	.	PUNCT
bam-7218	822	1	skeletal	skeletal	ADJ
bam-7218	822	2	muscle	muscle	NOUN
bam-7218	822	3	differentiation	differentiation	NOUN
bam-7218	822	4	is	be	AUX
bam-7218	822	5	achieved	achieve	VERB
bam-7218	822	6	using	use	VERB
bam-7218	822	7	genea	genea	NOUN
bam-7218	822	8	biocells	biocell	NOUN
bam-7218	822	9	'	'	PART
bam-7218	822	10	simple	simple	ADJ
bam-7218	822	11	three	three	NUM
bam-7218	822	12	media	medium	NOUN
bam-7218	822	13	process	process	NOUN
bam-7218	822	14	as	as	SCONJ
bam-7218	822	15	previously	previously	ADV
bam-7218	822	16	described	describe	VERB
bam-7218	822	17	by	by	ADP
bam-7218	822	18	caron	caron	PROPN
bam-7218	822	19	et	et	PROPN
bam-7218	822	20	al	al	PROPN
bam-7218	822	21	.	.	PUNCT
bam-7218	823	1	(	(	PUNCT
bam-7218	823	2	stem	stem	NOUN
bam-7218	823	3	cell	cell	NOUN
bam-7218	823	4	trans	tran	NOUN
bam-7218	823	5	med	med	PROPN
bam-7218	823	6	,	,	PUNCT
bam-7218	823	7	2016	2016	NUM
bam-7218	823	8	)	)	PUNCT
bam-7218	823	9	.	.	PUNCT
bam-7218	824	1	for	for	ADP
bam-7218	824	2	2d	2d	PROPN
bam-7218	824	3	modeling	modeling	NOUN
bam-7218	824	4	,	,	PUNCT
bam-7218	824	5	monolayer	monolayer	NOUN
bam-7218	824	6	hpscs	hpsc	NOUN
bam-7218	824	7	are	be	AUX
bam-7218	824	8	plated	plate	VERB
bam-7218	824	9	onto	onto	ADP
bam-7218	824	10	collagen	collagen	NOUN
bam-7218	824	11	i	i	NOUN
bam-7218	824	12	-	-	PUNCT
bam-7218	824	13	coated	coat	VERB
bam-7218	824	14	dishes	dish	NOUN
bam-7218	824	15	and	and	CCONJ
bam-7218	824	16	differentiated	differentiate	VERB
bam-7218	824	17	through	through	ADP
bam-7218	824	18	three	three	NUM
bam-7218	824	19	myogenic	myogenic	ADJ
bam-7218	824	20	developmental	developmental	ADJ
bam-7218	824	21	stages	stage	NOUN
bam-7218	824	22	(	(	PUNCT
bam-7218	824	23	e.	e.	PROPN
bam-7218	824	24	g.	g.	PROPN
bam-7218	824	25	satellite	satellite	PROPN
bam-7218	824	26	-	-	PUNCT
bam-7218	824	27	like	like	ADJ
bam-7218	824	28	cells	cell	NOUN
bam-7218	824	29	,	,	PUNCT
bam-7218	824	30	myoblasts	myoblast	NOUN
bam-7218	824	31	and	and	CCONJ
bam-7218	824	32	myotubes	myotube	NOUN
bam-7218	824	33	)	)	PUNCT
bam-7218	824	34	,	,	PUNCT
bam-7218	824	35	generating	generate	VERB
bam-7218	824	36	cultures	culture	NOUN
bam-7218	824	37	suitable	suitable	ADJ
bam-7218	824	38	for	for	ADP
bam-7218	824	39	morphological	morphological	ADJ
bam-7218	824	40	and	and	CCONJ
bam-7218	824	41	metabolic	metabolic	NOUN
bam-7218	824	42	analyses	analysis	NOUN
bam-7218	824	43	and	and	CCONJ
bam-7218	824	44	cell	cell	NOUN
bam-7218	824	45	-	-	PUNCT
bam-7218	824	46	based	base	VERB
bam-7218	824	47	drug	drug	NOUN
bam-7218	824	48	screening	screen	VERB
bam-7218	824	49	assays	assay	NOUN
bam-7218	824	50	.	.	PUNCT
bam-7218	825	1	for	for	ADP
bam-7218	825	2	3d	3d	PROPN
bam-7218	825	3	modeling	modeling	NOUN
bam-7218	825	4	,	,	PUNCT
bam-7218	825	5	similar	similar	ADJ
bam-7218	825	6	to	to	ADP
bam-7218	825	7	previously	previously	ADV
bam-7218	825	8	published	publish	VERB
bam-7218	825	9	work	work	NOUN
bam-7218	825	10	using	use	VERB
bam-7218	825	11	primary	primary	ADJ
bam-7218	825	12	human	human	ADJ
bam-7218	825	13	myoblasts	myoblast	NOUN
bam-7218	825	14	(	(	PUNCT
bam-7218	825	15	madden	madden	PROPN
bam-7218	825	16	et	et	PROPN
bam-7218	825	17	al	al	PROPN
bam-7218	825	18	.	.	PROPN
bam-7218	825	19	,	,	PUNCT
bam-7218	825	20	elife	elife	NOUN
bam-7218	825	21	,	,	PUNCT
bam-7218	825	22	2015	2015	NUM
bam-7218	825	23	)	)	PUNCT
bam-7218	825	24	,	,	PUNCT
bam-7218	825	25	hpsc	hpsc	NOUN
bam-7218	825	26	-	-	PUNCT
bam-7218	825	27	derived	derive	VERB
bam-7218	825	28	myoblasts	myoblast	NOUN
bam-7218	825	29	generated	generate	VERB
bam-7218	825	30	in	in	ADP
bam-7218	825	31	the	the	DET
bam-7218	825	32	2d	2d	NOUN
bam-7218	825	33	system	system	NOUN
bam-7218	825	34	were	be	AUX
bam-7218	825	35	encapsulated	encapsulate	VERB
bam-7218	825	36	in	in	ADP
bam-7218	825	37	hydrogel	hydrogel	NOUN
bam-7218	825	38	based	base	VERB
bam-7218	825	39	myobundles	myobundle	NOUN
bam-7218	825	40	to	to	PART
bam-7218	825	41	promote	promote	VERB
bam-7218	825	42	differentiation	differentiation	NOUN
bam-7218	825	43	into	into	ADP
bam-7218	825	44	myotubes	myotube	NOUN
bam-7218	825	45	using	use	VERB
bam-7218	825	46	a	a	DET
bam-7218	825	47	3d	3d	NUM
bam-7218	825	48	culture	culture	NOUN
bam-7218	825	49	environment	environment	NOUN
bam-7218	825	50	.	.	PUNCT
bam-7218	826	1	the	the	DET
bam-7218	826	2	3d	3d	PROPN
bam-7218	826	3	myobundles	myobundle	NOUN
bam-7218	826	4	are	be	AUX
bam-7218	826	5	suitable	suitable	ADJ
bam-7218	826	6	for	for	ADP
bam-7218	826	7	histology	histology	NOUN
bam-7218	826	8	,	,	PUNCT
bam-7218	826	9	as	as	ADV
bam-7218	826	10	well	well	ADV
bam-7218	826	11	as	as	ADP
bam-7218	826	12	contractile	contractile	NOUN
bam-7218	826	13	force	force	NOUN
bam-7218	826	14	measurements	measurement	NOUN
bam-7218	826	15	,	,	PUNCT
bam-7218	826	16	both	both	CCONJ
bam-7218	826	17	critical	critical	ADJ
bam-7218	826	18	clinical	clinical	ADJ
bam-7218	826	19	outcome	outcome	NOUN
bam-7218	826	20	measures	measure	NOUN
bam-7218	826	21	.	.	PUNCT
bam-7218	827	1	collectively	collectively	ADV
bam-7218	827	2	,	,	PUNCT
bam-7218	827	3	these	these	DET
bam-7218	827	4	platforms	platform	NOUN
bam-7218	827	5	provide	provide	VERB
bam-7218	827	6	a	a	DET
bam-7218	827	7	patient	patient	NOUN
bam-7218	827	8	-	-	PUNCT
bam-7218	827	9	specific	specific	ADJ
bam-7218	827	10	disease	disease	NOUN
bam-7218	827	11	-	-	PUNCT
bam-7218	827	12	in	in	ADP
bam-7218	827	13	-	-	PUNCT
bam-7218	827	14	adish	adish	NOUN
bam-7218	827	15	model	model	NOUN
bam-7218	827	16	with	with	ADP
bam-7218	827	17	clinically	clinically	ADV
bam-7218	827	18	-	-	PUNCT
bam-7218	827	19	relevant	relevant	ADJ
bam-7218	827	20	assay	assay	NOUN
bam-7218	827	21	endpoints	endpoint	NOUN
bam-7218	827	22	for	for	ADP
bam-7218	827	23	drug	drug	NOUN
bam-7218	827	24	discovery	discovery	NOUN
bam-7218	827	25	programs	program	NOUN
bam-7218	827	26	.	.	PUNCT
bam-7218	828	1	moreover	moreover	ADV
bam-7218	828	2	,	,	PUNCT
bam-7218	828	3	this	this	DET
bam-7218	828	4	approach	approach	NOUN
bam-7218	828	5	can	can	AUX
bam-7218	828	6	be	be	AUX
bam-7218	828	7	extended	extend	VERB
bam-7218	828	8	to	to	PART
bam-7218	828	9	model	model	VERB
bam-7218	828	10	a	a	DET
bam-7218	828	11	variety	variety	NOUN
bam-7218	828	12	of	of	ADP
bam-7218	828	13	other	other	ADJ
bam-7218	828	14	skeletal	skeletal	ADJ
bam-7218	828	15	muscle	muscle	NOUN
bam-7218	828	16	disorders	disorder	NOUN
bam-7218	828	17	.	.	PUNCT
bam-7218	829	1	p.04	p.04	NOUN
bam-7218	829	2	role	role	NOUN
bam-7218	829	3	of	of	ADP
bam-7218	829	4	igf-1	igf-1	NOUN
bam-7218	829	5	in	in	ADP
bam-7218	829	6	sarcopenia	sarcopenia	PROPN
bam-7218	829	7	francesca	francesca	PROPN
bam-7218	829	8	ascenzi	ascenzi	PROPN
bam-7218	829	9	(	(	PUNCT
bam-7218	829	10	a	a	X
bam-7218	829	11	)	)	PUNCT
bam-7218	829	12	,	,	PUNCT
bam-7218	829	13	laura	laura	NOUN
bam-7218	829	14	barberi	barberi	PROPN
bam-7218	829	15	(	(	PUNCT
bam-7218	829	16	b	b	NOUN
bam-7218	829	17	)	)	PUNCT
bam-7218	829	18	,	,	PUNCT
bam-7218	829	19	carmine	carmine	NOUN
bam-7218	829	20	nicoletti	nicoletti	NOUN
bam-7218	829	21	(	(	PUNCT
bam-7218	829	22	b	b	NOUN
bam-7218	829	23	)	)	PUNCT
bam-7218	829	24	,	,	PUNCT
bam-7218	829	25	antonio	antonio	PROPN
bam-7218	829	26	musarò	musarò	NOUN
bam-7218	829	27	(	(	PUNCT
bam-7218	829	28	a	a	DET
bam-7218	829	29	,	,	PUNCT
bam-7218	829	30	b	b	NOUN
bam-7218	829	31	)	)	PUNCT
bam-7218	829	32	(	(	PUNCT
bam-7218	829	33	a	a	PRON
bam-7218	829	34	)	)	PUNCT
bam-7218	829	35	center	center	NOUN
bam-7218	829	36	for	for	ADP
bam-7218	829	37	life	life	NOUN
bam-7218	829	38	nano	nano	NOUN
bam-7218	829	39	science	science	NOUN
bam-7218	829	40	at	at	ADP
bam-7218	829	41	sapienza	sapienza	PROPN
bam-7218	829	42	,	,	PUNCT
bam-7218	829	43	istituto	istituto	X
bam-7218	829	44	italiano	italiano	NOUN
bam-7218	829	45	di	di	X
bam-7218	829	46	tecnologia	tecnologia	PROPN
bam-7218	829	47	,	,	PUNCT
bam-7218	829	48	rome	rome	PROPN
bam-7218	829	49	;	;	PUNCT
bam-7218	829	50	(	(	PUNCT
bam-7218	829	51	b	b	X
bam-7218	829	52	)	)	PUNCT
bam-7218	829	53	institute	institute	NOUN
bam-7218	829	54	pasteurcenci	pasteurcenci	PROPN
bam-7218	829	55	bolognetti	bolognetti	PROPN
bam-7218	829	56	,	,	PUNCT
bam-7218	829	57	dahfmo	dahfmo	NOUN
bam-7218	829	58	-	-	PUNCT
bam-7218	829	59	unit	unit	NOUN
bam-7218	829	60	of	of	ADP
bam-7218	829	61	histology	histology	NOUN
bam-7218	829	62	and	and	CCONJ
bam-7218	829	63	medical	medical	ADJ
bam-7218	829	64	embryology	embryology	PROPN
bam-7218	829	65	,	,	PUNCT
bam-7218	829	66	sapienza	sapienza	PROPN
bam-7218	829	67	university	university	PROPN
bam-7218	829	68	of	of	ADP
bam-7218	829	69	rome	rome	PROPN
bam-7218	829	70	,	,	PUNCT
bam-7218	829	71	rome	rome	PROPN
bam-7218	829	72	,	,	PUNCT
bam-7218	829	73	italy	italy	PROPN
bam-7218	829	74	.	.	PUNCT
bam-7218	830	1	e	e	X
bam-7218	830	2	-	-	NOUN
bam-7218	830	3	mail	mail	NOUN
bam-7218	830	4	:	:	PUNCT
bam-7218	830	5	francesca.ascenzi@uniroma1.it	francesca.ascenzi@uniroma1.it	DET
bam-7218	830	6	sarcopenia	sarcopenia	NOUN
bam-7218	830	7	is	be	AUX
bam-7218	830	8	the	the	DET
bam-7218	830	9	progressive	progressive	ADJ
bam-7218	830	10	aging	age	VERB
bam-7218	830	11	-	-	PUNCT
bam-7218	830	12	related	relate	VERB
bam-7218	830	13	loss	loss	NOUN
bam-7218	830	14	of	of	ADP
bam-7218	830	15	skeletal	skeletal	ADJ
bam-7218	830	16	muscle	muscle	NOUN
bam-7218	830	17	mass	mass	NOUN
bam-7218	830	18	and	and	CCONJ
bam-7218	830	19	function	function	NOUN
bam-7218	830	20	occurring	occur	VERB
bam-7218	830	21	during	during	ADP
bam-7218	830	22	aging	aging	NOUN
bam-7218	830	23	.	.	PUNCT
bam-7218	831	1	it	it	PRON
bam-7218	831	2	is	be	AUX
bam-7218	831	3	the	the	DET
bam-7218	831	4	result	result	NOUN
bam-7218	831	5	of	of	ADP
bam-7218	831	6	multiple	multiple	ADJ
bam-7218	831	7	factors	factor	NOUN
bam-7218	831	8	,	,	PUNCT
bam-7218	831	9	including	include	VERB
bam-7218	831	10	changes	change	NOUN
bam-7218	831	11	in	in	ADP
bam-7218	831	12	the	the	DET
bam-7218	831	13	metabolic	metabolic	NOUN
bam-7218	831	14	state	state	NOUN
bam-7218	831	15	or	or	CCONJ
bam-7218	831	16	in	in	ADP
bam-7218	831	17	the	the	DET
bam-7218	831	18	neuromuscular	neuromuscular	ADJ
bam-7218	831	19	system	system	NOUN
bam-7218	831	20	,	,	PUNCT
bam-7218	831	21	inflammatory	inflammatory	ADJ
bam-7218	831	22	pathway	pathway	NOUN
bam-7218	831	23	activation	activation	NOUN
bam-7218	831	24	,	,	PUNCT
bam-7218	831	25	altered	alter	VERB
bam-7218	831	26	turnover	turnover	NOUN
bam-7218	831	27	of	of	ADP
bam-7218	831	28	contractile	contractile	ADJ
bam-7218	831	29	proteins	protein	NOUN
bam-7218	831	30	and	and	CCONJ
bam-7218	831	31	organelles	organelle	NOUN
bam-7218	831	32	as	as	ADV
bam-7218	831	33	well	well	ADV
bam-7218	831	34	as	as	ADP
bam-7218	831	35	altered	alter	VERB
bam-7218	831	36	production	production	NOUN
bam-7218	831	37	and	and	CCONJ
bam-7218	831	38	tissue	tissue	NOUN
bam-7218	831	39	responsiveness	responsiveness	NOUN
bam-7218	831	40	of	of	ADP
bam-7218	831	41	trophic	trophic	ADJ
bam-7218	831	42	factors	factor	NOUN
bam-7218	831	43	.	.	PUNCT
bam-7218	832	1	in	in	ADP
bam-7218	832	2	particular	particular	ADJ
bam-7218	832	3	changes	change	NOUN
bam-7218	832	4	in	in	ADP
bam-7218	832	5	hormonal	hormonal	ADJ
bam-7218	832	6	level	level	NOUN
bam-7218	832	7	,	,	PUNCT
bam-7218	832	8	including	include	VERB
bam-7218	832	9	decrease	decrease	NOUN
bam-7218	832	10	of	of	ADP
bam-7218	832	11	insulin	insulin	NOUN
bam-7218	832	12	-	-	PUNCT
bam-7218	832	13	like	like	ADJ
bam-7218	832	14	growth	growth	NOUN
bam-7218	832	15	factor	factor	NOUN
bam-7218	832	16	(	(	PUNCT
bam-7218	832	17	igf-1	igf-1	NOUN
bam-7218	832	18	)	)	PUNCT
bam-7218	832	19	,	,	PUNCT
bam-7218	832	20	contribute	contribute	VERB
bam-7218	832	21	to	to	ADP
bam-7218	832	22	sarcopenic	sarcopenic	ADJ
bam-7218	832	23	condition	condition	NOUN
bam-7218	832	24	.	.	PUNCT
bam-7218	833	1	we	we	PRON
bam-7218	833	2	demonstrated	demonstrate	VERB
bam-7218	833	3	that	that	SCONJ
bam-7218	833	4	the	the	DET
bam-7218	833	5	overexpression	overexpression	NOUN
bam-7218	833	6	of	of	ADP
bam-7218	833	7	igf-1	igf-1	NOUN
bam-7218	833	8	in	in	ADP
bam-7218	833	9	skeletal	skeletal	ADJ
bam-7218	833	10	muscle	muscle	NOUN
bam-7218	833	11	was	be	AUX
bam-7218	833	12	able	able	ADJ
bam-7218	833	13	to	to	PART
bam-7218	833	14	counter	counter	VERB
bam-7218	833	15	the	the	DET
bam-7218	833	16	decrease	decrease	NOUN
bam-7218	833	17	in	in	ADP
bam-7218	833	18	muscle	muscle	PROPN
bam-7218	833	19	mass	mass	PROPN
bam-7218	833	20	,	,	PUNCT
bam-7218	833	21	csa	csa	PROPN
bam-7218	833	22	and	and	CCONJ
bam-7218	833	23	strength	strength	NOUN
bam-7218	833	24	,	,	PUNCT
bam-7218	833	25	in	in	ADP
bam-7218	833	26	24	24	NUM
bam-7218	833	27	months	month	NOUN
bam-7218	833	28	age	age	NOUN
bam-7218	833	29	old	old	ADJ
bam-7218	833	30	mice	mouse	NOUN
bam-7218	833	31	.	.	PUNCT
bam-7218	834	1	moreover	moreover	ADV
bam-7218	834	2	,	,	PUNCT
bam-7218	834	3	overexpression	overexpression	NOUN
bam-7218	834	4	of	of	ADP
bam-7218	834	5	igf-1	igf-1	ADV
bam-7218	834	6	improved	improve	VERB
bam-7218	834	7	insulin	insulin	NOUN
bam-7218	834	8	sensitivity	sensitivity	NOUN
bam-7218	834	9	and	and	CCONJ
bam-7218	834	10	glucose	glucose	NOUN
bam-7218	834	11	tolerance	tolerance	NOUN
bam-7218	834	12	..	..	PUNCT
bam-7218	834	13	mailto:jamshid.arjomand@geneabiocells.com	mailto:jamshid.arjomand@geneabiocells.com	PROPN
bam-7218	834	14	mailto:francesca.ascenzi@uniroma1.it	mailto:francesca.ascenzi@uniroma1.it	PROPN
bam-7218	834	15	14	14	NUM
bam-7218	834	16	th	th	NOUN
bam-7218	834	17	iiim	iiim	NOUN
bam-7218	834	18	meeting	meeting	NOUN
bam-7218	834	19	,	,	PUNCT
bam-7218	834	20	assisi	assisi	PROPN
bam-7218	834	21	,	,	PUNCT
bam-7218	834	22	italy	italy	PROPN
bam-7218	834	23	october	october	PROPN
bam-7218	834	24	12	12	NUM
bam-7218	834	25	-	-	SYM
bam-7218	834	26	15	15	NUM
bam-7218	834	27	2017	2017	NUM
bam-7218	834	28	eur	eur	PROPN
bam-7218	834	29	j	j	PROPN
bam-7218	834	30	transl	transl	PROPN
bam-7218	834	31	myol	myol	ADV
bam-7218	834	32	27	27	NUM
bam-7218	834	33	(	(	PUNCT
bam-7218	834	34	4	4	NUM
bam-7218	834	35	):	):	SYM
bam-7218	834	36	185	185	NUM
bam-7218	834	37	-	-	SYM
bam-7218	834	38	224	224	NUM
bam-7218	834	39	210	210	NUM
bam-7218	834	40	p.05	p.05	NOUN
bam-7218	834	41	pgc-1α	pgc-1α	NOUN
bam-7218	834	42	overexpression	overexpression	NOUN
bam-7218	834	43	in	in	ADP
bam-7218	834	44	the	the	DET
bam-7218	834	45	skeletal	skeletal	ADJ
bam-7218	834	46	muscle	muscle	NOUN
bam-7218	834	47	:	:	PUNCT
bam-7218	834	48	effects	effect	NOUN
bam-7218	834	49	on	on	ADP
bam-7218	834	50	myogenesis	myogenesis	NOUN
bam-7218	834	51	marc	marc	PROPN
bam-7218	834	52	beltrà	beltrà	PROPN
bam-7218	834	53	,	,	PUNCT
bam-7218	834	54	fabrizio	fabrizio	PROPN
bam-7218	834	55	pin	pin	NOUN
bam-7218	834	56	,	,	PUNCT
bam-7218	834	57	riccardo	riccardo	PROPN
bam-7218	834	58	ballarò	ballarò	NOUN
bam-7218	834	59	,	,	PUNCT
bam-7218	834	60	ambra	ambra	NOUN
bam-7218	834	61	iannuzzi	iannuzzi	NOUN
bam-7218	834	62	,	,	PUNCT
bam-7218	834	63	fabio	fabio	PROPN
bam-7218	834	64	penna	penna	PROPN
bam-7218	834	65	,	,	PUNCT
bam-7218	834	66	paola	paola	PROPN
bam-7218	834	67	costelli	costelli	PROPN
bam-7218	834	68	dept	dept	PROPN
bam-7218	834	69	of	of	ADP
bam-7218	834	70	clinical	clinical	ADJ
bam-7218	834	71	and	and	CCONJ
bam-7218	834	72	biological	biological	ADJ
bam-7218	834	73	sciences	science	NOUN
bam-7218	834	74	,	,	PUNCT
bam-7218	834	75	university	university	PROPN
bam-7218	834	76	of	of	ADP
bam-7218	834	77	turin	turin	PROPN
bam-7218	834	78	,	,	PUNCT
bam-7218	834	79	italy	italy	PROPN
bam-7218	834	80	;	;	PUNCT
bam-7218	834	81	interuniversity	interuniversity	NOUN
bam-7218	834	82	institute	institute	PROPN
bam-7218	834	83	of	of	ADP
bam-7218	834	84	myology	myology	PROPN
bam-7218	834	85	,	,	PUNCT
bam-7218	834	86	italy	italy	PROPN
bam-7218	834	87	.	.	PUNCT
bam-7218	835	1	e	e	X
bam-7218	835	2	-	-	NOUN
bam-7218	835	3	mail	mail	NOUN
bam-7218	835	4	:	:	PUNCT
bam-7218	835	5	marc.beltrabach@unito.it	marc.beltrabach@unito.it	PROPN
bam-7218	835	6	peroxisome	peroxisome	VERB
bam-7218	835	7	proliferator	proliferator	PROPN
bam-7218	835	8	-	-	PUNCT
bam-7218	835	9	activated	activate	VERB
bam-7218	835	10	receptor	receptor	NOUN
bam-7218	835	11	γ	γ	NOUN
bam-7218	835	12	coactivator	coactivator	NOUN
bam-7218	835	13	1α	1α	NUM
bam-7218	835	14	(	(	PUNCT
bam-7218	835	15	pgc-1α	pgc-1α	NOUN
bam-7218	835	16	)	)	PUNCT
bam-7218	835	17	is	be	AUX
bam-7218	835	18	a	a	DET
bam-7218	835	19	master	master	NOUN
bam-7218	835	20	regulator	regulator	NOUN
bam-7218	835	21	of	of	ADP
bam-7218	835	22	mitochondrial	mitochondrial	ADJ
bam-7218	835	23	biogenesis	biogenesis	NOUN
bam-7218	835	24	.	.	PUNCT
bam-7218	836	1	in	in	ADP
bam-7218	836	2	skeletal	skeletal	ADJ
bam-7218	836	3	muscle	muscle	NOUN
bam-7218	836	4	,	,	PUNCT
bam-7218	836	5	pgc-1α	pgc-1α	NOUN
bam-7218	836	6	expression	expression	NOUN
bam-7218	836	7	is	be	AUX
bam-7218	836	8	induced	induce	VERB
bam-7218	836	9	by	by	ADP
bam-7218	836	10	exercise	exercise	NOUN
bam-7218	836	11	.	.	PUNCT
bam-7218	837	1	along	along	ADP
bam-7218	837	2	this	this	DET
bam-7218	837	3	line	line	NOUN
bam-7218	837	4	,	,	PUNCT
bam-7218	837	5	transgenic	transgenic	NOUN
bam-7218	837	6	mckpgc-1α	mckpgc-1α	NOUN
bam-7218	837	7	,	,	PUNCT
bam-7218	837	8	which	which	PRON
bam-7218	837	9	overexpress	overexpress	NOUN
bam-7218	837	10	this	this	DET
bam-7218	837	11	transcription	transcription	NOUN
bam-7218	837	12	factor	factor	NOUN
bam-7218	837	13	specifically	specifically	ADV
bam-7218	837	14	in	in	ADP
bam-7218	837	15	the	the	DET
bam-7218	837	16	skeletal	skeletal	ADJ
bam-7218	837	17	muscle	muscle	NOUN
bam-7218	837	18	,	,	PUNCT
bam-7218	837	19	are	be	AUX
bam-7218	837	20	characterized	characterize	VERB
bam-7218	837	21	by	by	ADP
bam-7218	837	22	enhanced	enhance	VERB
bam-7218	837	23	exercise	exercise	NOUN
bam-7218	837	24	performance	performance	NOUN
bam-7218	837	25	in	in	ADP
bam-7218	837	26	comparison	comparison	NOUN
bam-7218	837	27	with	with	ADP
bam-7218	837	28	wild	wild	ADJ
bam-7218	837	29	-	-	PUNCT
bam-7218	837	30	type	type	NOUN
bam-7218	837	31	animals	animal	NOUN
bam-7218	837	32	1	1	NUM
bam-7218	837	33	;	;	PUNCT
bam-7218	837	34	this	this	PRON
bam-7218	837	35	is	be	AUX
bam-7218	837	36	mainly	mainly	ADV
bam-7218	837	37	due	due	ADJ
bam-7218	837	38	to	to	ADP
bam-7218	837	39	increased	increase	VERB
bam-7218	837	40	myofiber	myofiber	ADJ
bam-7218	837	41	mitochondrial	mitochondrial	ADJ
bam-7218	837	42	content	content	NOUN
bam-7218	837	43	that	that	PRON
bam-7218	837	44	results	result	VERB
bam-7218	837	45	in	in	ADP
bam-7218	837	46	markedly	markedly	ADV
bam-7218	837	47	improved	improve	VERB
bam-7218	837	48	energy	energy	NOUN
bam-7218	837	49	metabolism	metabolism	NOUN
bam-7218	837	50	.	.	PUNCT
bam-7218	838	1	in	in	ADP
bam-7218	838	2	addition	addition	NOUN
bam-7218	838	3	to	to	ADP
bam-7218	838	4	an	an	DET
bam-7218	838	5	increased	increase	VERB
bam-7218	838	6	proportion	proportion	NOUN
bam-7218	838	7	of	of	ADP
bam-7218	838	8	oxidative	oxidative	ADJ
bam-7218	838	9	fibers	fiber	NOUN
bam-7218	838	10	vs	vs	ADP
bam-7218	838	11	glycolytic	glycolytic	ADJ
bam-7218	838	12	ones	one	NOUN
bam-7218	838	13	2	2	NUM
bam-7218	838	14	,	,	PUNCT
bam-7218	838	15	we	we	PRON
bam-7218	838	16	found	find	VERB
bam-7218	838	17	a	a	DET
bam-7218	838	18	high	high	ADJ
bam-7218	838	19	number	number	NOUN
bam-7218	838	20	of	of	ADP
bam-7218	838	21	fibers	fiber	NOUN
bam-7218	838	22	with	with	ADP
bam-7218	838	23	centrally	centrally	ADV
bam-7218	838	24	located	locate	VERB
bam-7218	838	25	nuclei	nucleus	NOUN
bam-7218	838	26	,	,	PUNCT
bam-7218	838	27	which	which	PRON
bam-7218	838	28	is	be	AUX
bam-7218	838	29	indicative	indicative	ADJ
bam-7218	838	30	of	of	ADP
bam-7218	838	31	muscle	muscle	NOUN
bam-7218	838	32	regeneration	regeneration	NOUN
bam-7218	838	33	.	.	PUNCT
bam-7218	839	1	moreover	moreover	ADV
bam-7218	839	2	,	,	PUNCT
bam-7218	839	3	myogenic	myogenic	ADJ
bam-7218	839	4	stem	stem	NOUN
bam-7218	839	5	cells	cell	NOUN
bam-7218	839	6	are	be	AUX
bam-7218	839	7	more	more	ADV
bam-7218	839	8	abundant	abundant	ADJ
bam-7218	839	9	in	in	ADP
bam-7218	839	10	transgenic	transgenic	NOUN
bam-7218	839	11	mice	mouse	NOUN
bam-7218	839	12	compared	compare	VERB
bam-7218	839	13	to	to	ADP
bam-7218	839	14	wild	wild	ADJ
bam-7218	839	15	-	-	PUNCT
bam-7218	839	16	type	type	NOUN
bam-7218	839	17	animals	animal	NOUN
bam-7218	839	18	,	,	PUNCT
bam-7218	839	19	and	and	CCONJ
bam-7218	839	20	when	when	SCONJ
bam-7218	839	21	isolated	isolated	ADJ
bam-7218	839	22	and	and	CCONJ
bam-7218	839	23	cultured	cultured	ADJ
bam-7218	839	24	in	in	ADP
bam-7218	839	25	differentiating	differentiate	VERB
bam-7218	839	26	medium	medium	NOUN
bam-7218	839	27	,	,	PUNCT
bam-7218	839	28	they	they	PRON
bam-7218	839	29	form	form	VERB
bam-7218	839	30	larger	large	ADJ
bam-7218	839	31	myotubes	myotube	NOUN
bam-7218	839	32	.	.	PUNCT
bam-7218	840	1	starting	start	VERB
bam-7218	840	2	from	from	ADP
bam-7218	840	3	this	this	DET
bam-7218	840	4	point	point	NOUN
bam-7218	840	5	,	,	PUNCT
bam-7218	840	6	the	the	DET
bam-7218	840	7	aim	aim	NOUN
bam-7218	840	8	of	of	ADP
bam-7218	840	9	the	the	DET
bam-7218	840	10	study	study	NOUN
bam-7218	840	11	was	be	AUX
bam-7218	840	12	to	to	PART
bam-7218	840	13	investigate	investigate	VERB
bam-7218	840	14	if	if	SCONJ
bam-7218	840	15	stem	stem	NOUN
bam-7218	840	16	cells	cell	NOUN
bam-7218	840	17	from	from	ADP
bam-7218	840	18	mck	mck	ADJ
bam-7218	840	19	-	-	PUNCT
bam-7218	840	20	pgc-1α	pgc-1α	NOUN
bam-7218	840	21	mice	mouse	NOUN
bam-7218	840	22	can	can	AUX
bam-7218	840	23	improve	improve	VERB
bam-7218	840	24	myogenesis	myogenesis	NOUN
bam-7218	840	25	.	.	PUNCT
bam-7218	841	1	muscles	muscle	NOUN
bam-7218	841	2	from	from	ADP
bam-7218	841	3	male	male	ADJ
bam-7218	841	4	wild	wild	ADJ
bam-7218	841	5	-	-	PUNCT
bam-7218	841	6	type	type	NOUN
bam-7218	841	7	and	and	CCONJ
bam-7218	841	8	mck	mck	ADJ
bam-7218	841	9	-	-	PUNCT
bam-7218	841	10	pgc-1α	pgc-1α	NOUN
bam-7218	841	11	mice	mouse	NOUN
bam-7218	841	12	were	be	AUX
bam-7218	841	13	subjected	subject	VERB
bam-7218	841	14	to	to	ADP
bam-7218	841	15	mild	mild	ADJ
bam-7218	841	16	digestion	digestion	NOUN
bam-7218	841	17	and	and	CCONJ
bam-7218	841	18	mononuclear	mononuclear	ADJ
bam-7218	841	19	cells	cell	NOUN
bam-7218	841	20	were	be	AUX
bam-7218	841	21	isolated	isolate	VERB
bam-7218	841	22	by	by	ADP
bam-7218	841	23	filtration	filtration	NOUN
bam-7218	841	24	.	.	PUNCT
bam-7218	842	1	these	these	DET
bam-7218	842	2	cells	cell	NOUN
bam-7218	842	3	were	be	AUX
bam-7218	842	4	then	then	ADV
bam-7218	842	5	transplanted	transplant	VERB
bam-7218	842	6	into	into	ADP
bam-7218	842	7	the	the	DET
bam-7218	842	8	tibialis	tibialis	PROPN
bam-7218	842	9	anterior	anterior	ADJ
bam-7218	842	10	muscle	muscle	NOUN
bam-7218	842	11	of	of	ADP
bam-7218	842	12	female	female	ADJ
bam-7218	842	13	wild	wild	ADJ
bam-7218	842	14	-	-	PUNCT
bam-7218	842	15	type	type	NOUN
bam-7218	842	16	mice	mouse	NOUN
bam-7218	842	17	,	,	PUNCT
bam-7218	842	18	either	either	CCONJ
bam-7218	842	19	injured	injure	VERB
bam-7218	842	20	(	(	PUNCT
bam-7218	842	21	bacl2	bacl2	PROPN
bam-7218	842	22	i.m	i.m	PROPN
bam-7218	842	23	.	.	PUNCT
bam-7218	842	24	injection	injection	NOUN
bam-7218	842	25	8	8	NUM
bam-7218	842	26	hours	hour	NOUN
bam-7218	842	27	before	before	ADP
bam-7218	842	28	cell	cell	NOUN
bam-7218	842	29	transplantation	transplantation	NOUN
bam-7218	842	30	)	)	PUNCT
bam-7218	842	31	or	or	CCONJ
bam-7218	842	32	not	not	PART
bam-7218	842	33	.	.	PUNCT
bam-7218	843	1	the	the	DET
bam-7218	843	2	animals	animal	NOUN
bam-7218	843	3	were	be	AUX
bam-7218	843	4	euthanized	euthanize	VERB
bam-7218	843	5	12	12	NUM
bam-7218	843	6	days	day	NOUN
bam-7218	843	7	after	after	ADP
bam-7218	843	8	bacl2	bacl2	NOUN
bam-7218	843	9	injection	injection	NOUN
bam-7218	843	10	.	.	PUNCT
bam-7218	844	1	hematoxylin	hematoxylin	NOUN
bam-7218	844	2	/	/	SYM
bam-7218	844	3	eosin	eosin	NOUN
bam-7218	844	4	staining	stain	VERB
bam-7218	844	5	of	of	ADP
bam-7218	844	6	muscles	muscle	NOUN
bam-7218	844	7	transplanted	transplant	VERB
bam-7218	844	8	with	with	ADP
bam-7218	844	9	wt	wt	ADV
bam-7218	844	10	-	-	PUNCT
bam-7218	844	11	derived	derive	VERB
bam-7218	844	12	cells	cell	NOUN
bam-7218	844	13	shows	show	VERB
bam-7218	844	14	improved	improved	ADJ
bam-7218	844	15	regeneration	regeneration	NOUN
bam-7218	844	16	.	.	PUNCT
bam-7218	845	1	on	on	ADP
bam-7218	845	2	the	the	DET
bam-7218	845	3	contrary	contrary	NOUN
bam-7218	845	4	,	,	PUNCT
bam-7218	845	5	all	all	DET
bam-7218	845	6	the	the	DET
bam-7218	845	7	muscles	muscle	NOUN
bam-7218	845	8	injected	inject	VERB
bam-7218	845	9	with	with	ADP
bam-7218	845	10	mck	mck	PROPN
bam-7218	845	11	-	-	PUNCT
bam-7218	845	12	pgc-1α	pgc-1α	NOUN
bam-7218	845	13	-	-	PUNCT
bam-7218	845	14	derived	derive	VERB
bam-7218	845	15	cells	cell	NOUN
bam-7218	845	16	show	show	VERB
bam-7218	845	17	an	an	DET
bam-7218	845	18	increase	increase	NOUN
bam-7218	845	19	of	of	ADP
bam-7218	845	20	centrally	centrally	ADV
bam-7218	845	21	located	locate	VERB
bam-7218	845	22	nuclei	nucleus	NOUN
bam-7218	845	23	,	,	PUNCT
bam-7218	845	24	altered	alter	VERB
bam-7218	845	25	myofiber	myofiber	PROPN
bam-7218	845	26	cross	cross	ADJ
bam-7218	845	27	-	-	ADJ
bam-7218	845	28	sectional	sectional	ADJ
bam-7218	845	29	area	area	NOUN
bam-7218	845	30	distribution	distribution	NOUN
bam-7218	845	31	and	and	CCONJ
bam-7218	845	32	marked	mark	VERB
bam-7218	845	33	sdh	sdh	PROPN
bam-7218	845	34	staining	staining	NOUN
bam-7218	845	35	.	.	PUNCT
bam-7218	846	1	the	the	DET
bam-7218	846	2	expression	expression	NOUN
bam-7218	846	3	of	of	ADP
bam-7218	846	4	molecular	molecular	ADJ
bam-7218	846	5	markers	marker	NOUN
bam-7218	846	6	of	of	ADP
bam-7218	846	7	regeneration	regeneration	NOUN
bam-7218	846	8	is	be	AUX
bam-7218	846	9	consistent	consistent	ADJ
bam-7218	846	10	with	with	ADP
bam-7218	846	11	the	the	DET
bam-7218	846	12	histological	histological	ADJ
bam-7218	846	13	pattern	pattern	NOUN
bam-7218	846	14	.	.	PUNCT
bam-7218	847	1	the	the	DET
bam-7218	847	2	results	result	NOUN
bam-7218	847	3	obtained	obtain	VERB
bam-7218	847	4	in	in	ADP
bam-7218	847	5	the	the	DET
bam-7218	847	6	present	present	ADJ
bam-7218	847	7	study	study	NOUN
bam-7218	847	8	suggest	suggest	VERB
bam-7218	847	9	that	that	SCONJ
bam-7218	847	10	cells	cell	NOUN
bam-7218	847	11	isolated	isolate	VERB
bam-7218	847	12	from	from	ADP
bam-7218	847	13	mck	mck	ADJ
bam-7218	847	14	-	-	PUNCT
bam-7218	847	15	pgc-1α	pgc-1α	NOUN
bam-7218	847	16	donor	donor	NOUN
bam-7218	847	17	mice	mouse	NOUN
bam-7218	847	18	are	be	AUX
bam-7218	847	19	able	able	ADJ
bam-7218	847	20	to	to	PART
bam-7218	847	21	fuse	fuse	VERB
bam-7218	847	22	with	with	ADP
bam-7218	847	23	recipient	recipient	NOUN
bam-7218	847	24	muscle	muscle	NOUN
bam-7218	847	25	myofibers	myofiber	NOUN
bam-7218	847	26	partially	partially	ADV
bam-7218	847	27	inducing	induce	VERB
bam-7218	847	28	a	a	DET
bam-7218	847	29	shift	shift	NOUN
bam-7218	847	30	towards	towards	ADP
bam-7218	847	31	oxidative	oxidative	ADJ
bam-7218	847	32	metabolism	metabolism	NOUN
bam-7218	847	33	and	and	CCONJ
bam-7218	847	34	affecting	affect	VERB
bam-7218	847	35	regeneration	regeneration	NOUN
bam-7218	847	36	.	.	PUNCT
bam-7218	848	1	references	reference	NOUN
bam-7218	848	2	1	1	NUM
bam-7218	848	3	.	.	PUNCT
bam-7218	848	4	calvo	calvo	PROPN
bam-7218	848	5	ja	ja	PROPN
bam-7218	848	6	,	,	PUNCT
bam-7218	848	7	daniels	daniels	PROPN
bam-7218	848	8	tg	tg	PROPN
bam-7218	848	9	,	,	PUNCT
bam-7218	848	10	wang	wang	PROPN
bam-7218	848	11	xm	xm	PROPN
bam-7218	848	12	,	,	PUNCT
bam-7218	848	13	et	et	PROPN
bam-7218	848	14	al	al	PROPN
bam-7218	848	15	.	.	PROPN
bam-7218	848	16	muscle	muscle	NOUN
bam-7218	848	17	-	-	PUNCT
bam-7218	848	18	specific	specific	ADJ
bam-7218	848	19	expression	expression	NOUN
bam-7218	848	20	of	of	ADP
bam-7218	848	21	ppar	ppar	NOUN
bam-7218	848	22	coactivator-1	coactivator-1	NUM
bam-7218	848	23	improves	improve	VERB
bam-7218	848	24	exercise	exercise	NOUN
bam-7218	848	25	performance	performance	NOUN
bam-7218	848	26	and	and	CCONJ
bam-7218	848	27	increases	increase	NOUN
bam-7218	848	28	peak	peak	VERB
bam-7218	848	29	oxygen	oxygen	NOUN
bam-7218	848	30	uptake	uptake	NOUN
bam-7218	848	31	.	.	PUNCT
bam-7218	849	1	j	j	PROPN
bam-7218	849	2	appl	appl	PROPN
bam-7218	849	3	physiol	physiol	PROPN
bam-7218	849	4	2008;104:1304–12	2008;104:1304–12	PROPN
bam-7218	849	5	.	.	PROPN
bam-7218	850	1	2	2	NUM
bam-7218	850	2	.	.	X
bam-7218	850	3	lin	lin	PROPN
bam-7218	850	4	j	j	PROPN
bam-7218	850	5	,	,	PUNCT
bam-7218	850	6	wu	wu	PROPN
bam-7218	850	7	h	h	PROPN
bam-7218	850	8	,	,	PUNCT
bam-7218	850	9	tarr	tarr	PROPN
bam-7218	850	10	pt	pt	PROPN
bam-7218	850	11	,	,	PUNCT
bam-7218	850	12	et	et	PROPN
bam-7218	850	13	al	al	PROPN
bam-7218	850	14	.	.	PROPN
bam-7218	850	15	transcriptional	transcriptional	ADJ
bam-7218	850	16	co	co	NOUN
bam-7218	850	17	-	-	NOUN
bam-7218	850	18	activator	activator	NOUN
bam-7218	850	19	pgc-1	pgc-1	NOUN
bam-7218	850	20	alpha	alpha	NOUN
bam-7218	850	21	drives	drive	VERB
bam-7218	850	22	the	the	DET
bam-7218	850	23	formation	formation	NOUN
bam-7218	850	24	of	of	ADP
bam-7218	850	25	slow	slow	ADJ
bam-7218	850	26	-	-	PUNCT
bam-7218	850	27	twitch	twitch	NOUN
bam-7218	850	28	muscle	muscle	NOUN
bam-7218	850	29	fibres	fibre	NOUN
bam-7218	850	30	.	.	PUNCT
bam-7218	851	1	nature	nature	NOUN
bam-7218	851	2	2002;418(6899):797	2002;418(6899):797	NUM
bam-7218	851	3	-	-	SYM
bam-7218	851	4	801	801	NUM
bam-7218	851	5	.	.	PUNCT
bam-7218	852	1	p.06	p.06	ADP
bam-7218	852	2	in	in	ADP
bam-7218	852	3	early	early	ADJ
bam-7218	852	4	stages	stage	NOUN
bam-7218	852	5	of	of	ADP
bam-7218	852	6	cancer	cancer	NOUN
bam-7218	852	7	-	-	PUNCT
bam-7218	852	8	cachexia	cachexia	NOUN
bam-7218	852	9	,	,	PUNCT
bam-7218	852	10	loss	loss	NOUN
bam-7218	852	11	of	of	ADP
bam-7218	852	12	mass	mass	NOUN
bam-7218	852	13	of	of	ADP
bam-7218	852	14	fast	fast	ADJ
bam-7218	852	15	-	-	PUNCT
bam-7218	852	16	twitch	twitch	NOUN
bam-7218	852	17	fibers	fiber	NOUN
bam-7218	852	18	results	result	NOUN
bam-7218	852	19	from	from	ADP
bam-7218	852	20	mitochondria	mitochondria	PROPN
bam-7218	852	21	and	and	CCONJ
bam-7218	852	22	sr	sr	PROPN
bam-7218	852	23	reduction	reduction	NOUN
bam-7218	852	24	.	.	PUNCT
bam-7218	853	1	fernanda	fernanda	PROPN
bam-7218	853	2	paschoal	paschoal	AUX
bam-7218	853	3	blegniski	blegniski	NOUN
bam-7218	853	4	(	(	PUNCT
bam-7218	853	5	a	a	X
bam-7218	853	6	)	)	PUNCT
bam-7218	853	7	,	,	PUNCT
bam-7218	853	8	claudia	claudia	NOUN
bam-7218	853	9	pecorai	pecorai	NOUN
bam-7218	853	10	(	(	PUNCT
bam-7218	853	11	b	b	NOUN
bam-7218	853	12	)	)	PUNCT
bam-7218	853	13	,	,	PUNCT
bam-7218	853	14	rubens	ruben	NOUN
bam-7218	853	15	cecchini	cecchini	PROPN
bam-7218	853	16	(	(	PUNCT
bam-7218	853	17	a	a	X
bam-7218	853	18	)	)	PUNCT
bam-7218	853	19	;	;	PUNCT
bam-7218	853	20	feliciano	feliciano	PROPN
bam-7218	853	21	protasi	protasi	PROPN
bam-7218	853	22	(	(	PUNCT
bam-7218	853	23	b	b	NOUN
bam-7218	853	24	)	)	PUNCT
bam-7218	853	25	,	,	PUNCT
bam-7218	853	26	simona	simona	NOUN
bam-7218	853	27	boncompagni	boncompagni	NOUN
bam-7218	853	28	(	(	PUNCT
bam-7218	853	29	b	b	NOUN
bam-7218	853	30	)	)	PUNCT
bam-7218	853	31	,	,	PUNCT
bam-7218	853	32	flávia	flávia	PROPN
bam-7218	853	33	alessandra	alessandra	PROPN
bam-7218	853	34	guarnier	guarnier	NOUN
bam-7218	853	35	(	(	PUNCT
bam-7218	853	36	a	a	X
bam-7218	853	37	)	)	PUNCT
bam-7218	853	38	(	(	PUNCT
bam-7218	853	39	a	a	X
bam-7218	853	40	)	)	PUNCT
bam-7218	853	41	dept	dept	NOUN
bam-7218	853	42	of	of	ADP
bam-7218	853	43	general	general	ADJ
bam-7218	853	44	pathology	pathology	PROPN
bam-7218	853	45	,	,	PUNCT
bam-7218	853	46	univ	univ	PROPN
bam-7218	853	47	.	.	PUNCT
bam-7218	854	1	estadual	estadual	PROPN
bam-7218	854	2	de	de	PROPN
bam-7218	854	3	londrina	londrina	PROPN
bam-7218	854	4	,	,	PUNCT
bam-7218	854	5	londrina	londrina	PROPN
bam-7218	854	6	,	,	PUNCT
bam-7218	854	7	pr	pr	NOUN
bam-7218	854	8	,	,	PUNCT
bam-7218	854	9	brazil	brazil	PROPN
bam-7218	854	10	;	;	PUNCT
bam-7218	854	11	(	(	PUNCT
bam-7218	854	12	b	b	X
bam-7218	854	13	)	)	PUNCT
bam-7218	854	14	cesi	cesi	PROPN
bam-7218	854	15	-	-	PUNCT
bam-7218	854	16	met	meet	VERB
bam-7218	854	17	,	,	PUNCT
bam-7218	854	18	center	center	NOUN
bam-7218	854	19	for	for	ADP
bam-7218	854	20	research	research	NOUN
bam-7218	854	21	on	on	ADP
bam-7218	854	22	ageing	age	VERB
bam-7218	854	23	and	and	CCONJ
bam-7218	854	24	translational	translational	ADJ
bam-7218	854	25	medicine	medicine	NOUN
bam-7218	854	26	,	,	PUNCT
bam-7218	854	27	univ	univ	PROPN
bam-7218	854	28	.	.	PUNCT
bam-7218	855	1	g.	g.	PROPN
bam-7218	855	2	d'annunzio	d'annunzio	PROPN
bam-7218	855	3	,	,	PUNCT
bam-7218	855	4	chieti	chieti	PROPN
bam-7218	855	5	,	,	PUNCT
bam-7218	855	6	italy	italy	PROPN
bam-7218	855	7	.	.	PUNCT
bam-7218	856	1	e	e	X
bam-7218	856	2	-	-	NOUN
bam-7218	856	3	mail	mail	NOUN
bam-7218	856	4	:	:	PUNCT
bam-7218	856	5	fprotasi@unich.it	fprotasi@unich.it	NOUN
bam-7218	856	6	fast	fast	ADJ
bam-7218	856	7	-	-	PUNCT
bam-7218	856	8	twitch	twitch	NOUN
bam-7218	856	9	fibers	fiber	NOUN
bam-7218	856	10	are	be	AUX
bam-7218	856	11	more	more	ADV
bam-7218	856	12	affected	affected	ADJ
bam-7218	856	13	during	during	ADP
bam-7218	856	14	the	the	DET
bam-7218	856	15	muscle	muscle	NOUN
bam-7218	856	16	waste	waste	NOUN
bam-7218	856	17	induced	induce	VERB
bam-7218	856	18	by	by	ADP
bam-7218	856	19	cancer	cancer	NOUN
bam-7218	856	20	cachexia	cachexia	PROPN
bam-7218	856	21	.	.	PUNCT
bam-7218	857	1	the	the	DET
bam-7218	857	2	current	current	ADJ
bam-7218	857	3	literature	literature	NOUN
bam-7218	857	4	correlates	correlate	VERB
bam-7218	857	5	the	the	DET
bam-7218	857	6	proteolysis	proteolysis	NOUN
bam-7218	857	7	-	-	PUNCT
bam-7218	857	8	related	relate	VERB
bam-7218	857	9	atrophy	atrophy	NOUN
bam-7218	857	10	(	(	PUNCT
bam-7218	857	11	which	which	PRON
bam-7218	857	12	usually	usually	ADV
bam-7218	857	13	occurs	occur	VERB
bam-7218	857	14	in	in	ADP
bam-7218	857	15	later	later	ADJ
bam-7218	857	16	stages	stage	NOUN
bam-7218	857	17	of	of	ADP
bam-7218	857	18	cachexia	cachexia	NOUN
bam-7218	857	19	syndrome	syndrome	NOUN
bam-7218	857	20	)	)	PUNCT
bam-7218	857	21	to	to	PART
bam-7218	857	22	oxidative	oxidative	VERB
bam-7218	857	23	damage	damage	NOUN
bam-7218	857	24	of	of	ADP
bam-7218	857	25	proteins	protein	NOUN
bam-7218	857	26	.	.	PUNCT
bam-7218	858	1	in	in	ADP
bam-7218	858	2	the	the	DET
bam-7218	858	3	present	present	ADJ
bam-7218	858	4	study	study	NOUN
bam-7218	858	5	,	,	PUNCT
bam-7218	858	6	we	we	PRON
bam-7218	858	7	investigated	investigate	VERB
bam-7218	858	8	oxidative	oxidative	ADJ
bam-7218	858	9	modifications	modification	NOUN
bam-7218	858	10	,	,	PUNCT
bam-7218	858	11	ultrastructural	ultrastructural	ADJ
bam-7218	858	12	modifications	modification	NOUN
bam-7218	858	13	in	in	ADP
bam-7218	858	14	mitochondria	mitochondria	NOUN
bam-7218	858	15	and	and	CCONJ
bam-7218	858	16	sarcoplasmic	sarcoplasmic	NOUN
bam-7218	858	17	reticulum	reticulum	NOUN
bam-7218	858	18	(	(	PUNCT
bam-7218	858	19	sr	sr	PROPN
bam-7218	858	20	)	)	PUNCT
bam-7218	858	21	,	,	PUNCT
bam-7218	858	22	and	and	CCONJ
bam-7218	858	23	the	the	DET
bam-7218	858	24	correlation	correlation	NOUN
bam-7218	858	25	with	with	ADP
bam-7218	858	26	muscle	muscle	NOUN
bam-7218	858	27	loss	loss	NOUN
bam-7218	858	28	in	in	ADP
bam-7218	858	29	edl	edl	PROPN
bam-7218	858	30	and	and	CCONJ
bam-7218	858	31	soleus	soleus	ADJ
bam-7218	858	32	muscles	muscle	NOUN
bam-7218	858	33	(	(	PUNCT
bam-7218	858	34	respectively	respectively	ADV
bam-7218	858	35	fastand	fastand	ADJ
bam-7218	858	36	slowtwitch	slowtwitch	NOUN
bam-7218	858	37	muscles	muscle	NOUN
bam-7218	858	38	)	)	PUNCT
bam-7218	858	39	in	in	ADP
bam-7218	858	40	an	an	DET
bam-7218	858	41	early	early	ADJ
bam-7218	858	42	stage	stage	NOUN
bam-7218	858	43	of	of	ADP
bam-7218	858	44	cachexia	cachexia	PROPN
bam-7218	858	45	(	(	PUNCT
bam-7218	858	46	precachexia	precachexia	PROPN
bam-7218	858	47	)	)	PUNCT
bam-7218	858	48	.	.	PUNCT
bam-7218	859	1	male	male	PROPN
bam-7218	859	2	wistar	wistar	PROPN
bam-7218	859	3	rats	rat	NOUN
bam-7218	859	4	were	be	AUX
bam-7218	859	5	subcutaneously	subcutaneously	ADV
bam-7218	859	6	inoculated	inoculate	VERB
bam-7218	859	7	with	with	ADP
bam-7218	859	8	a	a	DET
bam-7218	859	9	suspension	suspension	NOUN
bam-7218	859	10	of	of	ADP
bam-7218	859	11	walker-256	walker-256	ADJ
bam-7218	859	12	tumor	tumor	NOUN
bam-7218	859	13	cells	cell	NOUN
bam-7218	859	14	,	,	PUNCT
bam-7218	859	15	and	and	CCONJ
bam-7218	859	16	divided	divide	VERB
bam-7218	859	17	in	in	ADP
bam-7218	859	18	2	2	NUM
bam-7218	859	19	groups	group	NOUN
bam-7218	859	20	:	:	PUNCT
bam-7218	859	21	tumor	tumor	NOUN
bam-7218	859	22	bearing	bear	VERB
bam-7218	859	23	rats	rat	NOUN
bam-7218	859	24	(	(	PUNCT
bam-7218	859	25	t	t	NOUN
bam-7218	859	26	)	)	PUNCT
bam-7218	859	27	,	,	PUNCT
bam-7218	859	28	and	and	CCONJ
bam-7218	859	29	tumor	tumor	NOUN
bam-7218	859	30	bearing	bear	VERB
bam-7218	859	31	rats	rat	NOUN
bam-7218	859	32	treated	treat	VERB
bam-7218	859	33	with	with	ADP
bam-7218	859	34	n	n	X
bam-7218	859	35	-	-	PUNCT
bam-7218	859	36	acetylcisteine	acetylcisteine	NOUN
bam-7218	859	37	(	(	PUNCT
bam-7218	859	38	tnac	tnac	NOUN
bam-7218	859	39	;	;	PUNCT
bam-7218	859	40	nac	nac	PROPN
bam-7218	859	41	1	1	NUM
bam-7218	859	42	%	%	NOUN
bam-7218	859	43	ad	ad	NOUN
bam-7218	859	44	libitum	libitum	NOUN
bam-7218	859	45	in	in	ADP
bam-7218	859	46	drinking	drinking	NOUN
bam-7218	859	47	water	water	NOUN
bam-7218	859	48	)	)	PUNCT
bam-7218	859	49	,	,	PUNCT
bam-7218	859	50	a	a	DET
bam-7218	859	51	drug	drug	NOUN
bam-7218	859	52	known	know	VERB
bam-7218	859	53	to	to	PART
bam-7218	859	54	promote	promote	VERB
bam-7218	859	55	increased	increase	VERB
bam-7218	859	56	antioxidant	antioxidant	ADJ
bam-7218	859	57	capacity	capacity	NOUN
bam-7218	859	58	in	in	ADP
bam-7218	859	59	tissues	tissue	NOUN
bam-7218	859	60	.	.	PUNCT
bam-7218	860	1	a	a	DET
bam-7218	860	2	control	control	NOUN
bam-7218	860	3	group	group	NOUN
bam-7218	860	4	(	(	PUNCT
bam-7218	860	5	c	c	NOUN
bam-7218	860	6	)	)	PUNCT
bam-7218	860	7	without	without	ADP
bam-7218	860	8	tumor	tumor	NOUN
bam-7218	860	9	implantation	implantation	NOUN
bam-7218	860	10	or	or	CCONJ
bam-7218	860	11	nac	nac	NOUN
bam-7218	860	12	treatment	treatment	NOUN
bam-7218	860	13	was	be	AUX
bam-7218	860	14	also	also	ADV
bam-7218	860	15	added	add	VERB
bam-7218	860	16	.	.	PUNCT
bam-7218	861	1	after	after	ADP
bam-7218	861	2	5	5	NUM
bam-7218	861	3	days	day	NOUN
bam-7218	861	4	,	,	PUNCT
bam-7218	861	5	precachexia	precachexia	PROPN
bam-7218	861	6	was	be	AUX
bam-7218	861	7	characterized	characterize	VERB
bam-7218	861	8	in	in	ADP
bam-7218	861	9	t	t	NOUN
bam-7218	861	10	animals	animal	NOUN
bam-7218	861	11	according	accord	VERB
bam-7218	861	12	to	to	ADP
bam-7218	861	13	the	the	DET
bam-7218	861	14	criteria	criterion	NOUN
bam-7218	861	15	pre	pre	VERB
bam-7218	861	16	-	-	VERB
bam-7218	861	17	established	establish	VERB
bam-7218	861	18	by	by	ADP
bam-7218	861	19	fearon	fearon	PROPN
bam-7218	861	20	et	et	PROPN
bam-7218	861	21	al	al	PROPN
bam-7218	861	22	.	.	PROPN
bam-7218	862	1	(	(	PUNCT
bam-7218	862	2	2011	2011	NUM
bam-7218	862	3	;	;	PUNCT
bam-7218	862	4	lancet	lancet	PROPN
bam-7218	862	5	oncol	oncol	PROPN
bam-7218	862	6	)	)	PUNCT
bam-7218	862	7	.	.	PUNCT
bam-7218	863	1	tumor	tumor	NOUN
bam-7218	863	2	implantation	implantation	NOUN
bam-7218	863	3	caused	cause	VERB
bam-7218	863	4	decrease	decrease	NOUN
bam-7218	863	5	in	in	ADP
bam-7218	863	6	general	general	ADJ
bam-7218	863	7	body	body	NOUN
bam-7218	863	8	weight	weight	NOUN
bam-7218	863	9	(	(	PUNCT
bam-7218	863	10	-2.77	-2.77	NUM
bam-7218	863	11	%	%	NOUN
bam-7218	863	12	)	)	PUNCT
bam-7218	863	13	,	,	PUNCT
bam-7218	863	14	followed	follow	VERB
bam-7218	863	15	by	by	ADP
bam-7218	863	16	a	a	DET
bam-7218	863	17	significant	significant	ADJ
bam-7218	863	18	weight	weight	NOUN
bam-7218	863	19	loss	loss	NOUN
bam-7218	863	20	in	in	ADP
bam-7218	863	21	edl	edl	PROPN
bam-7218	863	22	muscle	muscle	NOUN
bam-7218	863	23	(	(	PUNCT
bam-7218	863	24	-15.33	-15.33	NOUN
bam-7218	863	25	%	%	NOUN
bam-7218	863	26	)	)	PUNCT
bam-7218	863	27	,	,	PUNCT
bam-7218	863	28	contrasting	contrast	VERB
bam-7218	863	29	with	with	ADP
bam-7218	863	30	the	the	DET
bam-7218	863	31	small	small	ADJ
bam-7218	863	32	mass	mass	NOUN
bam-7218	863	33	loss	loss	NOUN
bam-7218	863	34	of	of	ADP
bam-7218	863	35	soleus	soleus	NOUN
bam-7218	863	36	(	(	PUNCT
bam-7218	863	37	-5.14	-5.14	NOUN
bam-7218	863	38	%	%	NOUN
bam-7218	863	39	)	)	PUNCT
bam-7218	863	40	.	.	PUNCT
bam-7218	864	1	we	we	PRON
bam-7218	864	2	measured	measure	VERB
bam-7218	864	3	both	both	CCONJ
bam-7218	864	4	protein	protein	NOUN
bam-7218	864	5	and	and	CCONJ
bam-7218	864	6	membrane	membrane	NOUN
bam-7218	864	7	oxidation	oxidation	NOUN
bam-7218	864	8	and	and	CCONJ
bam-7218	864	9	found	find	VERB
bam-7218	864	10	that	that	SCONJ
bam-7218	864	11	only	only	ADJ
bam-7218	864	12	membrane	membrane	NOUN
bam-7218	864	13	oxidation	oxidation	NOUN
bam-7218	864	14	was	be	AUX
bam-7218	864	15	significantly	significantly	ADV
bam-7218	864	16	increased	increase	VERB
bam-7218	864	17	in	in	ADP
bam-7218	864	18	edl	edl	PROPN
bam-7218	864	19	from	from	ADP
bam-7218	864	20	tumor	tumor	NOUN
bam-7218	864	21	bearing	bear	VERB
bam-7218	864	22	mice	mouse	NOUN
bam-7218	864	23	.	.	PUNCT
bam-7218	865	1	as	as	ADP
bam-7218	865	2	a	a	DET
bam-7218	865	3	result	result	NOUN
bam-7218	865	4	,	,	PUNCT
bam-7218	865	5	we	we	PRON
bam-7218	865	6	found	find	VERB
bam-7218	865	7	that	that	SCONJ
bam-7218	865	8	the	the	DET
bam-7218	865	9	volume	volume	NOUN
bam-7218	865	10	of	of	ADP
bam-7218	865	11	intracellular	intracellular	ADJ
bam-7218	865	12	membrane	membrane	NOUN
bam-7218	865	13	organelles	organelle	NOUN
bam-7218	865	14	such	such	ADJ
bam-7218	865	15	as	as	ADP
bam-7218	865	16	sr	sr	PROPN
bam-7218	865	17	and	and	CCONJ
bam-7218	865	18	mitochondria	mitochondria	PROPN
bam-7218	865	19	was	be	AUX
bam-7218	865	20	significantly	significantly	ADV
bam-7218	865	21	decreased	decrease	VERB
bam-7218	865	22	(	(	PUNCT
bam-7218	865	23	-18.89	-18.89	NOUN
bam-7218	865	24	%	%	NOUN
bam-7218	865	25	and	and	CCONJ
bam-7218	865	26	-22.41	-22.41	NOUN
bam-7218	865	27	%	%	NOUN
bam-7218	865	28	,	,	PUNCT
bam-7218	865	29	respectively	respectively	ADV
bam-7218	865	30	)	)	PUNCT
bam-7218	865	31	compared	compare	VERB
bam-7218	865	32	to	to	ADP
bam-7218	865	33	group	group	PROPN
bam-7218	865	34	c.	c.	PROPN
bam-7218	865	35	interestingly	interestingly	ADV
bam-7218	865	36	,	,	PUNCT
bam-7218	865	37	all	all	DET
bam-7218	865	38	differences	difference	NOUN
bam-7218	865	39	were	be	AUX
bam-7218	865	40	significantly	significantly	ADV
bam-7218	865	41	rescued	rescue	VERB
bam-7218	865	42	in	in	ADP
bam-7218	865	43	t	t	PROPN
bam-7218	865	44	-	-	PUNCT
bam-7218	865	45	nac	nac	PROPN
bam-7218	865	46	group	group	NOUN
bam-7218	865	47	,	,	PUNCT
bam-7218	865	48	suggesting	suggest	VERB
bam-7218	865	49	a	a	DET
bam-7218	865	50	central	central	ADJ
bam-7218	865	51	role	role	NOUN
bam-7218	865	52	of	of	ADP
bam-7218	865	53	oxidative	oxidative	ADJ
bam-7218	865	54	stress	stress	NOUN
bam-7218	865	55	in	in	ADP
bam-7218	865	56	the	the	DET
bam-7218	865	57	modifications	modification	NOUN
bam-7218	865	58	of	of	ADP
bam-7218	865	59	membrane	membrane	NOUN
bam-7218	865	60	compartments	compartment	NOUN
bam-7218	865	61	.	.	PUNCT
bam-7218	866	1	these	these	DET
bam-7218	866	2	data	datum	NOUN
bam-7218	866	3	suggests	suggest	VERB
bam-7218	866	4	that	that	SCONJ
bam-7218	866	5	in	in	ADP
bam-7218	866	6	pre	pre	ADJ
bam-7218	866	7	-	-	ADJ
bam-7218	866	8	cachectic	cachectic	ADJ
bam-7218	866	9	stages	stage	NOUN
bam-7218	866	10	:	:	PUNCT
bam-7218	866	11	1	1	X
bam-7218	866	12	)	)	PUNCT
bam-7218	866	13	glycolytic	glycolytic	ADJ
bam-7218	866	14	muscles	muscle	NOUN
bam-7218	866	15	are	be	AUX
bam-7218	866	16	already	already	ADV
bam-7218	866	17	more	more	ADV
bam-7218	866	18	prone	prone	ADJ
bam-7218	866	19	to	to	ADP
bam-7218	866	20	mass	mass	ADJ
bam-7218	866	21	waste	waste	NOUN
bam-7218	866	22	,	,	PUNCT
bam-7218	866	23	but	but	CCONJ
bam-7218	866	24	independently	independently	ADV
bam-7218	866	25	of	of	ADP
bam-7218	866	26	protein	protein	NOUN
bam-7218	866	27	oxidation	oxidation	NOUN
bam-7218	866	28	;	;	PUNCT
bam-7218	866	29	and	and	CCONJ
bam-7218	866	30	2	2	X
bam-7218	866	31	)	)	PUNCT
bam-7218	866	32	loss	loss	NOUN
bam-7218	866	33	of	of	ADP
bam-7218	866	34	membrane	membrane	NOUN
bam-7218	866	35	organelles	organelle	NOUN
bam-7218	866	36	could	could	AUX
bam-7218	866	37	play	play	VERB
bam-7218	866	38	an	an	DET
bam-7218	866	39	important	important	ADJ
bam-7218	866	40	role	role	NOUN
bam-7218	866	41	early	early	ADV
bam-7218	866	42	in	in	ADP
bam-7218	866	43	these	these	DET
bam-7218	866	44	initial	initial	ADJ
bam-7218	866	45	stages	stage	NOUN
bam-7218	866	46	.	.	PUNCT
bam-7218	867	1	supported	support	VERB
bam-7218	867	2	by	by	ADP
bam-7218	867	3	:	:	PUNCT
bam-7218	867	4	a	a	X
bam-7218	867	5	)	)	PUNCT
bam-7218	867	6	brazilian	brazilian	NOUN
bam-7218	867	7	ciências	ciências	PROPN
bam-7218	867	8	sem	sem	PROPN
bam-7218	867	9	fronteiras	fronteiras	PROPN
bam-7218	867	10	:	:	PUNCT
bam-7218	867	11	cnpq	cnpq	PROPN
bam-7218	867	12	233892/2014	233892/2014	NUM
bam-7218	867	13	-	-	SYM
bam-7218	867	14	1	1	NUM
bam-7218	867	15	and	and	CCONJ
bam-7218	867	16	brazilian	brazilian	ADJ
bam-7218	867	17	continuous	continuous	ADJ
bam-7218	867	18	flow	flow	NOUN
bam-7218	867	19	program	program	NOUN
bam-7218	867	20	to	to	PART
bam-7218	867	21	support	support	VERB
bam-7218	867	22	special	special	ADJ
bam-7218	867	23	projects	project	NOUN
bam-7218	867	24	(	(	PUNCT
bam-7218	867	25	973/2013	973/2013	NUM
bam-7218	867	26	)	)	PUNCT
bam-7218	867	27	to	to	ADP
bam-7218	867	28	fag	fag	NOUN
bam-7218	867	29	;	;	PUNCT
bam-7218	867	30	b	b	X
bam-7218	867	31	)	)	PUNCT
bam-7218	867	32	miur	miur	NOUN
bam-7218	867	33	future	future	NOUN
bam-7218	867	34	in	in	ADP
bam-7218	867	35	research	research	NOUN
bam-7218	867	36	:	:	PUNCT
bam-7218	867	37	rbfr13a20k	rbfr13a20k	NOUN
bam-7218	867	38	to	to	ADP
bam-7218	867	39	sb	sb	PROPN
bam-7218	867	40	.	.	PUNCT
bam-7218	868	1	mailto:marc.beltrabach@unito.it	mailto:marc.beltrabach@unito.it	PROPN
bam-7218	868	2	mailto:fprotasi@unich.it	mailto:fprotasi@unich.it	VERB
bam-7218	868	3	14	14	NUM
bam-7218	868	4	th	th	NUM
bam-7218	868	5	iiim	iiim	NOUN
bam-7218	868	6	meeting	meeting	NOUN
bam-7218	868	7	,	,	PUNCT
bam-7218	868	8	assisi	assisi	PROPN
bam-7218	868	9	,	,	PUNCT
bam-7218	868	10	italy	italy	PROPN
bam-7218	868	11	october	october	PROPN
bam-7218	868	12	12	12	NUM
bam-7218	868	13	-	-	SYM
bam-7218	868	14	15	15	NUM
bam-7218	868	15	2017	2017	NUM
bam-7218	868	16	eur	eur	PROPN
bam-7218	868	17	j	j	PROPN
bam-7218	868	18	transl	transl	PROPN
bam-7218	868	19	myol	myol	ADV
bam-7218	868	20	27	27	NUM
bam-7218	868	21	(	(	PUNCT
bam-7218	868	22	4	4	NUM
bam-7218	868	23	):	):	SYM
bam-7218	868	24	185	185	NUM
bam-7218	868	25	-	-	SYM
bam-7218	868	26	224	224	NUM
bam-7218	868	27	211	211	NUM
bam-7218	868	28	p.07	p.07	X
bam-7218	868	29	caveolin-3	caveolin-3	PROPN
bam-7218	868	30	,	,	PUNCT
bam-7218	868	31	murc	murc	NOUN
bam-7218	868	32	and	and	CCONJ
bam-7218	868	33	trim72	trim72	NOUN
bam-7218	868	34	predict	predict	VERB
bam-7218	868	35	myogenic	myogenic	ADJ
bam-7218	868	36	differentiation	differentiation	NOUN
bam-7218	868	37	in	in	ADP
bam-7218	868	38	the	the	DET
bam-7218	868	39	human	human	ADJ
bam-7218	868	40	embryonal	embryonal	ADJ
bam-7218	868	41	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-7218	868	42	rd	rd	PROPN
bam-7218	868	43	cell	cell	PROPN
bam-7218	868	44	line	line	PROPN
bam-7218	868	45	francesca	francesca	PROPN
bam-7218	868	46	bonazza	bonazza	PROPN
bam-7218	868	47	(	(	PUNCT
bam-7218	868	48	a	a	X
bam-7218	868	49	)	)	PUNCT
bam-7218	868	50	,	,	PUNCT
bam-7218	868	51	silvia	silvia	PROPN
bam-7218	868	52	codenotti	codenotti	PROPN
bam-7218	868	53	(	(	PUNCT
bam-7218	868	54	a	a	DET
bam-7218	868	55	,	,	PUNCT
bam-7218	868	56	b	b	NOUN
bam-7218	868	57	)	)	PUNCT
bam-7218	868	58	,	,	PUNCT
bam-7218	868	59	sara	sara	PROPN
bam-7218	868	60	gavazzi	gavazzi	PROPN
bam-7218	868	61	(	(	PUNCT
bam-7218	868	62	a	a	X
bam-7218	868	63	)	)	PUNCT
bam-7218	868	64	,	,	PUNCT
bam-7218	868	65	alessandro	alessandro	PROPN
bam-7218	868	66	fanzani	fanzani	PROPN
bam-7218	868	67	(	(	PUNCT
bam-7218	868	68	a	a	DET
bam-7218	868	69	,	,	PUNCT
bam-7218	868	70	b	b	NOUN
bam-7218	868	71	)	)	PUNCT
bam-7218	868	72	*	*	PUNCT
bam-7218	868	73	(	(	PUNCT
bam-7218	868	74	a	a	X
bam-7218	868	75	)	)	PUNCT
bam-7218	868	76	dept	dept	NOUN
bam-7218	868	77	of	of	ADP
bam-7218	868	78	molecular	molecular	ADJ
bam-7218	868	79	and	and	CCONJ
bam-7218	868	80	translational	translational	ADJ
bam-7218	868	81	medicine	medicine	NOUN
bam-7218	868	82	,	,	PUNCT
bam-7218	868	83	university	university	NOUN
bam-7218	868	84	of	of	ADP
bam-7218	868	85	brescia	brescia	PROPN
bam-7218	868	86	,	,	PUNCT
bam-7218	868	87	italy	italy	PROPN
bam-7218	868	88	;	;	PUNCT
bam-7218	868	89	(	(	PUNCT
bam-7218	868	90	b	b	X
bam-7218	868	91	)	)	PUNCT
bam-7218	868	92	interuniversity	interuniversity	NOUN
bam-7218	868	93	institute	institute	NOUN
bam-7218	868	94	of	of	ADP
bam-7218	868	95	myology	myology	NOUN
bam-7218	868	96	(	(	PUNCT
bam-7218	868	97	iim	iim	NOUN
bam-7218	868	98	)	)	PUNCT
bam-7218	868	99	,	,	PUNCT
bam-7218	868	100	rome	rome	PROPN
bam-7218	868	101	,	,	PUNCT
bam-7218	868	102	italy	italy	PROPN
bam-7218	868	103	.	.	PUNCT
bam-7218	869	1	e	e	X
bam-7218	869	2	-	-	NOUN
bam-7218	869	3	mail	mail	NOUN
bam-7218	869	4	:	:	PUNCT
bam-7218	870	1	fra.bonazza@gmail.com	fra.bonazza@gmail.com	PROPN
bam-7218	870	2	caveolin-3	caveolin-3	X
bam-7218	870	3	(	(	PUNCT
bam-7218	870	4	cav-3	cav-3	NOUN
bam-7218	870	5	)	)	PUNCT
bam-7218	870	6	,	,	PUNCT
bam-7218	870	7	muscle	muscle	NOUN
bam-7218	870	8	-	-	PUNCT
bam-7218	870	9	restricted	restrict	VERB
bam-7218	870	10	coiled	coil	VERB
bam-7218	870	11	coil	coil	NOUN
bam-7218	870	12	murc	murc	NOUN
bam-7218	870	13	(	(	PUNCT
bam-7218	870	14	also	also	ADV
bam-7218	870	15	referred	refer	VERB
bam-7218	870	16	to	to	ADP
bam-7218	870	17	as	as	ADP
bam-7218	870	18	cavin-4	cavin-4	NUM
bam-7218	870	19	)	)	PUNCT
bam-7218	870	20	and	and	CCONJ
bam-7218	870	21	the	the	DET
bam-7218	870	22	recently	recently	ADV
bam-7218	870	23	identified	identify	VERB
bam-7218	870	24	large	large	ADJ
bam-7218	870	25	tripartite	tripartite	ADJ
bam-7218	870	26	motif	motif	NOUN
bam-7218	870	27	trim72	trim72	NOUN
bam-7218	870	28	are	be	AUX
bam-7218	870	29	proteins	protein	NOUN
bam-7218	870	30	controlling	control	VERB
bam-7218	870	31	a	a	DET
bam-7218	870	32	number	number	NOUN
bam-7218	870	33	of	of	ADP
bam-7218	870	34	important	important	ADJ
bam-7218	870	35	processes	process	NOUN
bam-7218	870	36	in	in	ADP
bam-7218	870	37	skeletal	skeletal	ADJ
bam-7218	870	38	muscle	muscle	NOUN
bam-7218	870	39	,	,	PUNCT
bam-7218	870	40	ranging	range	VERB
bam-7218	870	41	from	from	ADP
bam-7218	870	42	myogenesis	myogenesis	NOUN
bam-7218	870	43	and	and	CCONJ
bam-7218	870	44	insulin	insulin	NOUN
bam-7218	870	45	signaling	signal	VERB
bam-7218	870	46	up	up	ADP
bam-7218	870	47	to	to	ADP
bam-7218	870	48	sarcolemma	sarcolemma	PROPN
bam-7218	870	49	repair	repair	NOUN
bam-7218	870	50	.	.	PUNCT
bam-7218	871	1	in	in	ADP
bam-7218	871	2	this	this	DET
bam-7218	871	3	study	study	NOUN
bam-7218	871	4	we	we	PRON
bam-7218	871	5	investigated	investigate	VERB
bam-7218	871	6	their	their	PRON
bam-7218	871	7	expression	expression	NOUN
bam-7218	871	8	in	in	ADP
bam-7218	871	9	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-7218	871	10	(	(	PUNCT
bam-7218	871	11	rms	rm	NOUN
bam-7218	871	12	)	)	PUNCT
bam-7218	871	13	,	,	PUNCT
bam-7218	871	14	a	a	DET
bam-7218	871	15	soft	soft	ADJ
bam-7218	871	16	tissue	tissue	NOUN
bam-7218	871	17	tumor	tumor	NOUN
bam-7218	871	18	showing	show	VERB
bam-7218	871	19	morphological	morphological	ADJ
bam-7218	871	20	and	and	CCONJ
bam-7218	871	21	biochemical	biochemical	ADJ
bam-7218	871	22	traits	trait	NOUN
bam-7218	871	23	of	of	ADP
bam-7218	871	24	the	the	DET
bam-7218	871	25	skeletal	skeletal	ADJ
bam-7218	871	26	muscle	muscle	NOUN
bam-7218	871	27	lineage	lineage	NOUN
bam-7218	871	28	.	.	PUNCT
bam-7218	872	1	immunohistochemical	immunohistochemical	ADJ
bam-7218	872	2	analysis	analysis	NOUN
bam-7218	872	3	showed	show	VERB
bam-7218	872	4	a	a	DET
bam-7218	872	5	similar	similar	ADJ
bam-7218	872	6	pattern	pattern	NOUN
bam-7218	872	7	of	of	ADP
bam-7218	872	8	expression	expression	NOUN
bam-7218	872	9	of	of	ADP
bam-7218	872	10	the	the	DET
bam-7218	872	11	three	three	NUM
bam-7218	872	12	proteins	protein	NOUN
bam-7218	872	13	in	in	ADP
bam-7218	872	14	different	different	ADJ
bam-7218	872	15	human	human	ADJ
bam-7218	872	16	rms	rm	NOUN
bam-7218	872	17	samples	sample	NOUN
bam-7218	872	18	.	.	PUNCT
bam-7218	873	1	immunoblotting	immunoblotte	VERB
bam-7218	873	2	analysis	analysis	NOUN
bam-7218	873	3	carried	carry	VERB
bam-7218	873	4	out	out	ADP
bam-7218	873	5	using	use	VERB
bam-7218	873	6	different	different	ADJ
bam-7218	873	7	rms	rm	NOUN
bam-7218	873	8	cell	cell	NOUN
bam-7218	873	9	lines	line	NOUN
bam-7218	873	10	showed	show	VERB
bam-7218	873	11	an	an	DET
bam-7218	873	12	increased	increase	VERB
bam-7218	873	13	expression	expression	NOUN
bam-7218	873	14	of	of	ADP
bam-7218	873	15	these	these	DET
bam-7218	873	16	proteins	protein	NOUN
bam-7218	873	17	during	during	ADP
bam-7218	873	18	myogenic	myogenic	ADJ
bam-7218	873	19	differentiation	differentiation	NOUN
bam-7218	873	20	as	as	ADP
bam-7218	873	21	compared	compare	VERB
bam-7218	873	22	to	to	ADP
bam-7218	873	23	proliferating	proliferate	VERB
bam-7218	873	24	cells	cell	NOUN
bam-7218	873	25	.	.	PUNCT
bam-7218	874	1	in	in	ADP
bam-7218	874	2	addition	addition	NOUN
bam-7218	874	3	,	,	PUNCT
bam-7218	874	4	confocal	confocal	ADJ
bam-7218	874	5	microscopy	microscopy	NOUN
bam-7218	874	6	analysis	analysis	NOUN
bam-7218	874	7	revealed	reveal	VERB
bam-7218	874	8	that	that	SCONJ
bam-7218	874	9	cav-3	cav-3	NOUN
bam-7218	874	10	,	,	PUNCT
bam-7218	874	11	murc	murc	NOUN
bam-7218	874	12	and	and	CCONJ
bam-7218	874	13	trim72	trim72	X
bam-7218	874	14	all	all	DET
bam-7218	874	15	co	co	NOUN
bam-7218	874	16	-	-	NOUN
bam-7218	874	17	localize	localize	VERB
bam-7218	874	18	at	at	ADP
bam-7218	874	19	the	the	DET
bam-7218	874	20	plasmalemma	plasmalemma	NOUN
bam-7218	874	21	of	of	ADP
bam-7218	874	22	differentiated	differentiated	ADJ
bam-7218	874	23	embryonal	embryonal	ADJ
bam-7218	874	24	rd	rd	NOUN
bam-7218	874	25	cells	cell	NOUN
bam-7218	874	26	.	.	PUNCT
bam-7218	875	1	ectopic	ectopic	ADJ
bam-7218	875	2	expression	expression	NOUN
bam-7218	875	3	of	of	ADP
bam-7218	875	4	a	a	DET
bam-7218	875	5	point	point	NOUN
bam-7218	875	6	mutated	mutate	VERB
bam-7218	875	7	cav-3	cav-3	AUX
bam-7218	875	8	p104l	p104l	PROPN
bam-7218	875	9	form	form	NOUN
bam-7218	875	10	in	in	ADP
bam-7218	875	11	rd	rd	NOUN
bam-7218	875	12	cells	cell	NOUN
bam-7218	875	13	was	be	AUX
bam-7218	875	14	sufficient	sufficient	ADJ
bam-7218	875	15	to	to	PART
bam-7218	875	16	mislocalize	mislocalize	VERB
bam-7218	875	17	both	both	PRON
bam-7218	875	18	murc	murc	NOUN
bam-7218	875	19	and	and	CCONJ
bam-7218	875	20	trim72	trim72	NOUN
bam-7218	875	21	into	into	ADP
bam-7218	875	22	perinuclear	perinuclear	ADJ
bam-7218	875	23	golgi	golgi	NOUN
bam-7218	875	24	-	-	PUNCT
bam-7218	875	25	like	like	ADJ
bam-7218	875	26	compartments	compartment	NOUN
bam-7218	875	27	,	,	PUNCT
bam-7218	875	28	leading	lead	VERB
bam-7218	875	29	to	to	ADP
bam-7218	875	30	a	a	DET
bam-7218	875	31	cell	cell	NOUN
bam-7218	875	32	phenotype	phenotype	NOUN
bam-7218	875	33	characterized	characterize	VERB
bam-7218	875	34	by	by	ADP
bam-7218	875	35	increased	increase	VERB
bam-7218	875	36	erk	erk	PROPN
bam-7218	875	37	phosphorylation	phosphorylation	NOUN
bam-7218	875	38	and	and	CCONJ
bam-7218	875	39	severe	severe	ADJ
bam-7218	875	40	impairment	impairment	NOUN
bam-7218	875	41	of	of	ADP
bam-7218	875	42	myogenic	myogenic	ADJ
bam-7218	875	43	differentiation	differentiation	NOUN
bam-7218	875	44	.	.	PUNCT
bam-7218	876	1	overall	overall	ADV
bam-7218	876	2	,	,	PUNCT
bam-7218	876	3	these	these	DET
bam-7218	876	4	data	datum	NOUN
bam-7218	876	5	suggest	suggest	VERB
bam-7218	876	6	that	that	SCONJ
bam-7218	876	7	a	a	DET
bam-7218	876	8	concurrent	concurrent	ADJ
bam-7218	876	9	expression	expression	NOUN
bam-7218	876	10	of	of	ADP
bam-7218	876	11	cav-3	cav-3	NOUN
bam-7218	876	12	,	,	PUNCT
bam-7218	876	13	murc	murc	ADJ
bam-7218	876	14	and	and	CCONJ
bam-7218	876	15	trim72	trim72	NOUN
bam-7218	876	16	configures	configure	VERB
bam-7218	876	17	as	as	ADP
bam-7218	876	18	a	a	DET
bam-7218	876	19	specific	specific	ADJ
bam-7218	876	20	signature	signature	NOUN
bam-7218	876	21	predicting	predict	VERB
bam-7218	876	22	and	and	CCONJ
bam-7218	876	23	regulating	regulate	VERB
bam-7218	876	24	cell	cell	NOUN
bam-7218	876	25	differentiation	differentiation	NOUN
bam-7218	876	26	in	in	ADP
bam-7218	876	27	rms	rm	NOUN
bam-7218	876	28	.	.	PUNCT
bam-7218	877	1	p.08	p.08	ADJ
bam-7218	877	2	physical	physical	ADJ
bam-7218	877	3	preconditioning	preconditioning	NOUN
bam-7218	877	4	prior	prior	ADV
bam-7218	877	5	to	to	ADP
bam-7218	877	6	hindlimb	hindlimb	NOUN
bam-7218	877	7	unloading	unload	VERB
bam-7218	877	8	preserves	preserve	NOUN
bam-7218	877	9	gastrocnemius	gastrocnemius	PROPN
bam-7218	877	10	mass	mass	PROPN
bam-7218	877	11	lorenza	lorenza	ADV
bam-7218	877	12	brocca	brocca	NOUN
bam-7218	877	13	(	(	PUNCT
bam-7218	877	14	a	a	X
bam-7218	877	15	)	)	PUNCT
bam-7218	877	16	,	,	PUNCT
bam-7218	877	17	roberto	roberto	PROPN
bam-7218	877	18	bottinelli	bottinelli	PROPN
bam-7218	877	19	(	(	PUNCT
bam-7218	877	20	a	a	DET
bam-7218	877	21	,	,	PUNCT
bam-7218	877	22	c	c	NOUN
bam-7218	877	23	,	,	PUNCT
bam-7218	877	24	d	d	NOUN
bam-7218	877	25	)	)	PUNCT
bam-7218	877	26	,	,	PUNCT
bam-7218	877	27	maria	maria	PROPN
bam-7218	877	28	antonietta	antonietta	VERB
bam-7218	877	29	pellegrino	pellegrino	NOUN
bam-7218	877	30	(	(	PUNCT
bam-7218	877	31	a	a	DET
bam-7218	877	32	,	,	PUNCT
bam-7218	877	33	b	b	NOUN
bam-7218	877	34	,	,	PUNCT
bam-7218	877	35	c	c	NOUN
bam-7218	877	36	)	)	PUNCT
bam-7218	877	37	(	(	PUNCT
bam-7218	877	38	a	a	X
bam-7218	877	39	)	)	PUNCT
bam-7218	877	40	dept	dept	NOUN
bam-7218	877	41	of	of	ADP
bam-7218	877	42	molecular	molecular	ADJ
bam-7218	877	43	medicine	medicine	NOUN
bam-7218	877	44	,	,	PUNCT
bam-7218	877	45	university	university	NOUN
bam-7218	877	46	of	of	ADP
bam-7218	877	47	pavia	pavia	PROPN
bam-7218	877	48	,	,	PUNCT
bam-7218	877	49	italy	italy	PROPN
bam-7218	877	50	;	;	PUNCT
bam-7218	877	51	(	(	PUNCT
bam-7218	877	52	b	b	X
bam-7218	877	53	)	)	PUNCT
bam-7218	877	54	interdipartimental	interdipartimental	ADJ
bam-7218	877	55	centre	centre	NOUN
bam-7218	877	56	for	for	ADP
bam-7218	877	57	biology	biology	NOUN
bam-7218	877	58	and	and	CCONJ
bam-7218	877	59	sport	sport	NOUN
bam-7218	877	60	medicine	medicine	NOUN
bam-7218	877	61	,	,	PUNCT
bam-7218	877	62	university	university	NOUN
bam-7218	877	63	of	of	ADP
bam-7218	877	64	pavia	pavia	PROPN
bam-7218	877	65	,	,	PUNCT
bam-7218	877	66	italy	italy	PROPN
bam-7218	877	67	;	;	PUNCT
bam-7218	877	68	(	(	PUNCT
bam-7218	877	69	c	c	X
bam-7218	877	70	)	)	PUNCT
bam-7218	877	71	interuniversity	interuniversity	NOUN
bam-7218	877	72	institute	institute	PROPN
bam-7218	877	73	of	of	ADP
bam-7218	877	74	myology	myology	NOUN
bam-7218	877	75	;	;	PUNCT
bam-7218	877	76	(	(	PUNCT
bam-7218	877	77	d	d	X
bam-7218	877	78	)	)	PUNCT
bam-7218	877	79	fondazione	fondazione	NOUN
bam-7218	877	80	salvatore	salvatore	NOUN
bam-7218	877	81	maugeri	maugeri	PROPN
bam-7218	877	82	(	(	PUNCT
bam-7218	877	83	irccs	irccs	PROPN
bam-7218	877	84	)	)	PUNCT
bam-7218	877	85	,	,	PUNCT
bam-7218	877	86	scientific	scientific	ADJ
bam-7218	877	87	institute	institute	NOUN
bam-7218	877	88	of	of	ADP
bam-7218	877	89	pavia	pavia	PROPN
bam-7218	877	90	,	,	PUNCT
bam-7218	877	91	italy	italy	PROPN
bam-7218	877	92	.	.	PUNCT
bam-7218	878	1	e	e	X
bam-7218	878	2	-	-	NOUN
bam-7218	878	3	mail	mail	NOUN
bam-7218	878	4	:	:	PUNCT
bam-7218	878	5	lorenza.brocca@unipv.it	lorenza.brocca@unipv.it	ADP
bam-7218	878	6	it	it	PRON
bam-7218	878	7	has	have	AUX
bam-7218	878	8	been	be	AUX
bam-7218	878	9	shown	show	VERB
bam-7218	878	10	that	that	SCONJ
bam-7218	878	11	mitochondrial	mitochondrial	ADJ
bam-7218	878	12	dysfunction	dysfunction	NOUN
bam-7218	878	13	modulates	modulate	NOUN
bam-7218	878	14	intracellular	intracellular	ADJ
bam-7218	878	15	pathways	pathway	NOUN
bam-7218	878	16	involved	involve	VERB
bam-7218	878	17	in	in	ADP
bam-7218	878	18	skeletal	skeletal	ADJ
bam-7218	878	19	muscle	muscle	NOUN
bam-7218	878	20	mass	mass	NOUN
bam-7218	878	21	control	control	NOUN
bam-7218	878	22	and	and	CCONJ
bam-7218	878	23	plays	play	VERB
bam-7218	878	24	a	a	DET
bam-7218	878	25	major	major	ADJ
bam-7218	878	26	role	role	NOUN
bam-7218	878	27	in	in	ADP
bam-7218	878	28	disuse	disuse	NOUN
bam-7218	878	29	atrophy	atrophy	NOUN
bam-7218	878	30	.	.	PUNCT
bam-7218	879	1	as	as	SCONJ
bam-7218	879	2	aerobic	aerobic	ADJ
bam-7218	879	3	exercise	exercise	NOUN
bam-7218	879	4	can	can	AUX
bam-7218	879	5	promote	promote	VERB
bam-7218	879	6	an	an	DET
bam-7218	879	7	oxidative	oxidative	ADJ
bam-7218	879	8	metabolic	metabolic	NOUN
bam-7218	879	9	program	program	NOUN
bam-7218	879	10	,	,	PUNCT
bam-7218	879	11	we	we	PRON
bam-7218	879	12	hypothesized	hypothesize	VERB
bam-7218	879	13	that	that	SCONJ
bam-7218	879	14	exercise	exercise	NOUN
bam-7218	879	15	training	training	NOUN
bam-7218	879	16	before	before	ADP
bam-7218	879	17	hindlimb	hindlimb	ADJ
bam-7218	879	18	suspension	suspension	NOUN
bam-7218	879	19	could	could	AUX
bam-7218	879	20	prevent	prevent	VERB
bam-7218	879	21	mitochondrial	mitochondrial	ADJ
bam-7218	879	22	dysfunction	dysfunction	NOUN
bam-7218	879	23	and	and	CCONJ
bam-7218	879	24	skeletal	skeletal	ADJ
bam-7218	879	25	muscle	muscle	NOUN
bam-7218	879	26	atrophy	atrophy	NOUN
bam-7218	879	27	.	.	PUNCT
bam-7218	880	1	to	to	PART
bam-7218	880	2	test	test	VERB
bam-7218	880	3	the	the	DET
bam-7218	880	4	latter	latter	ADJ
bam-7218	880	5	hypothesis	hypothesis	NOUN
bam-7218	880	6	the	the	DET
bam-7218	880	7	effects	effect	NOUN
bam-7218	880	8	of	of	ADP
bam-7218	880	9	aerobic	aerobic	ADJ
bam-7218	880	10	physical	physical	ADJ
bam-7218	880	11	preconditioning	precondition	VERB
bam-7218	880	12	on	on	ADP
bam-7218	880	13	mechanisms	mechanism	NOUN
bam-7218	880	14	involved	involve	VERB
bam-7218	880	15	in	in	ADP
bam-7218	880	16	muscle	muscle	NOUN
bam-7218	880	17	mass	mass	NOUN
bam-7218	880	18	maintenance	maintenance	NOUN
bam-7218	880	19	and	and	CCONJ
bam-7218	880	20	muscle	muscle	NOUN
bam-7218	880	21	mass	mass	NOUN
bam-7218	880	22	were	be	AUX
bam-7218	880	23	studied	study	VERB
bam-7218	880	24	.	.	PUNCT
bam-7218	881	1	mice	mouse	NOUN
bam-7218	881	2	were	be	AUX
bam-7218	881	3	divided	divide	VERB
bam-7218	881	4	into	into	ADP
bam-7218	881	5	4	4	NUM
bam-7218	881	6	groups	group	NOUN
bam-7218	881	7	:	:	PUNCT
bam-7218	881	8	7	7	NUM
bam-7218	881	9	days	day	NOUN
bam-7218	881	10	aerobic	aerobic	ADJ
bam-7218	881	11	training	training	NOUN
bam-7218	881	12	before	before	ADP
bam-7218	881	13	suspension	suspension	NOUN
bam-7218	881	14	(	(	PUNCT
bam-7218	881	15	ex+hu	ex+hu	NOUN
bam-7218	881	16	)	)	PUNCT
bam-7218	881	17	;	;	PUNCT
bam-7218	881	18	7	7	NUM
bam-7218	881	19	days	day	NOUN
bam-7218	881	20	exercise	exercise	VERB
bam-7218	881	21	only	only	ADV
bam-7218	881	22	(	(	PUNCT
bam-7218	881	23	ex	ex	NOUN
bam-7218	881	24	)	)	PUNCT
bam-7218	881	25	;	;	PUNCT
bam-7218	881	26	3	3	NUM
bam-7218	881	27	days	day	NOUN
bam-7218	881	28	of	of	ADP
bam-7218	881	29	hindlimb	hindlimb	NOUN
bam-7218	881	30	unloading	unloading	NOUN
bam-7218	881	31	(	(	PUNCT
bam-7218	881	32	hu	hu	PROPN
bam-7218	881	33	)	)	PUNCT
bam-7218	881	34	;	;	PUNCT
bam-7218	881	35	control	control	NOUN
bam-7218	881	36	(	(	PUNCT
bam-7218	881	37	ctrl	ctrl	NOUN
bam-7218	881	38	)	)	PUNCT
bam-7218	881	39	.	.	PUNCT
bam-7218	882	1	mice	mouse	NOUN
bam-7218	882	2	were	be	AUX
bam-7218	882	3	trained	train	VERB
bam-7218	882	4	daily	daily	ADV
bam-7218	882	5	on	on	ADP
bam-7218	882	6	treadmill	treadmill	NOUN
bam-7218	882	7	for	for	ADP
bam-7218	882	8	7	7	NUM
bam-7218	882	9	days	day	NOUN
bam-7218	882	10	.	.	PUNCT
bam-7218	883	1	after	after	ADP
bam-7218	883	2	3	3	NUM
bam-7218	883	3	days	day	NOUN
bam-7218	883	4	hu	hu	PROPN
bam-7218	883	5	,	,	PUNCT
bam-7218	883	6	gastrocnemius	gastrocnemius	NOUN
bam-7218	883	7	showed	show	VERB
bam-7218	883	8	atrophy	atrophy	NOUN
bam-7218	883	9	(	(	PUNCT
bam-7218	883	10	csa	csa	PROPN
bam-7218	883	11	:	:	PUNCT
bam-7218	883	12	ctrl	ctrl	VERB
bam-7218	883	13	1557±26	1557±26	NUM
bam-7218	883	14	vs	vs	ADP
bam-7218	883	15	hu	hu	PROPN
bam-7218	883	16	1300±134	1300±134	PROPN
bam-7218	883	17	)	)	PUNCT
bam-7218	883	18	,	,	PUNCT
bam-7218	883	19	ubiquitine	ubiquitine	ADJ
bam-7218	883	20	proteasome	proteasome	NOUN
bam-7218	883	21	system	system	NOUN
bam-7218	883	22	(	(	PUNCT
bam-7218	883	23	murf1	murf1	ADJ
bam-7218	883	24	and	and	CCONJ
bam-7218	883	25	atrogin1	atrogin1	NOUN
bam-7218	883	26	increase	increase	NOUN
bam-7218	883	27	)	)	PUNCT
bam-7218	883	28	,	,	PUNCT
bam-7218	883	29	autophagy	autophagy	ADJ
bam-7218	883	30	activation	activation	NOUN
bam-7218	883	31	(	(	PUNCT
bam-7218	883	32	lc3ii	lc3ii	PROPN
bam-7218	883	33	/	/	SYM
bam-7218	883	34	lc3i	lc3i	PROPN
bam-7218	883	35	increase	increase	NOUN
bam-7218	883	36	)	)	PUNCT
bam-7218	883	37	and	and	CCONJ
bam-7218	883	38	no	no	DET
bam-7218	883	39	change	change	NOUN
bam-7218	883	40	of	of	ADP
bam-7218	883	41	synthetic	synthetic	ADJ
bam-7218	883	42	pathway	pathway	NOUN
bam-7218	883	43	(	(	PUNCT
bam-7218	883	44	mtor	mtor	NOUN
bam-7218	883	45	)	)	PUNCT
bam-7218	883	46	compared	compare	VERB
bam-7218	883	47	to	to	AUX
bam-7218	883	48	control	control	VERB
bam-7218	883	49	mice	mouse	NOUN
bam-7218	883	50	.	.	PUNCT
bam-7218	884	1	gastrocnemius	gastrocnemius	NOUN
bam-7218	884	2	of	of	ADP
bam-7218	884	3	ex+hu	ex+hu	NUM
bam-7218	884	4	mice	mouse	NOUN
bam-7218	884	5	did	do	AUX
bam-7218	884	6	not	not	PART
bam-7218	884	7	show	show	VERB
bam-7218	884	8	muscle	muscle	NOUN
bam-7218	884	9	mass	mass	NOUN
bam-7218	884	10	loss	loss	NOUN
bam-7218	884	11	(	(	PUNCT
bam-7218	884	12	csa	csa	PROPN
bam-7218	884	13	:	:	PUNCT
bam-7218	884	14	hu	hu	PROPN
bam-7218	884	15	1300±134	1300±134	PROPN
bam-7218	884	16	vs	vs	ADP
bam-7218	884	17	7ex+hu	7ex+hu	NUM
bam-7218	884	18	1479±5	1479±5	NUM
bam-7218	884	19	)	)	PUNCT
bam-7218	884	20	.	.	PUNCT
bam-7218	885	1	such	such	ADJ
bam-7218	885	2	prevention	prevention	NOUN
bam-7218	885	3	of	of	ADP
bam-7218	885	4	muscle	muscle	NOUN
bam-7218	885	5	atrophy	atrophy	NOUN
bam-7218	885	6	in	in	ADP
bam-7218	885	7	ex+hu	ex+hu	NUM
bam-7218	885	8	was	be	AUX
bam-7218	885	9	associated	associate	VERB
bam-7218	885	10	with	with	ADP
bam-7218	885	11	:	:	PUNCT
bam-7218	885	12	(	(	PUNCT
bam-7218	885	13	i	i	NOUN
bam-7218	885	14	)	)	PUNCT
bam-7218	885	15	a	a	DET
bam-7218	885	16	significant	significant	ADJ
bam-7218	885	17	enhancement	enhancement	NOUN
bam-7218	885	18	of	of	ADP
bam-7218	885	19	tfam	tfam	NOUN
bam-7218	885	20	and	and	CCONJ
bam-7218	885	21	nrf-1	nrf-1	NUM
bam-7218	885	22	mrna	mrna	PROPN
bam-7218	885	23	levels	level	NOUN
bam-7218	885	24	,	,	PUNCT
bam-7218	885	25	two	two	NUM
bam-7218	885	26	transcription	transcription	NOUN
bam-7218	885	27	factors	factor	NOUN
bam-7218	885	28	regulating	regulate	VERB
bam-7218	885	29	mitochondrial	mitochondrial	ADJ
bam-7218	885	30	biogenesis	biogenesis	NOUN
bam-7218	885	31	;	;	PUNCT
bam-7218	885	32	(	(	PUNCT
bam-7218	885	33	ii	ii	NOUN
bam-7218	885	34	)	)	PUNCT
bam-7218	885	35	a	a	DET
bam-7218	885	36	significant	significant	ADJ
bam-7218	885	37	increase	increase	NOUN
bam-7218	885	38	of	of	ADP
bam-7218	885	39	mrna	mrna	PROPN
bam-7218	885	40	levels	level	NOUN
bam-7218	885	41	of	of	ADP
bam-7218	885	42	key	key	ADJ
bam-7218	885	43	factors	factor	NOUN
bam-7218	885	44	involved	involve	VERB
bam-7218	885	45	in	in	ADP
bam-7218	885	46	mitochondrial	mitochondrial	ADJ
bam-7218	885	47	dynamic	dynamic	ADJ
bam-7218	885	48	,	,	PUNCT
bam-7218	885	49	namely	namely	ADV
bam-7218	885	50	profusion	profusion	NOUN
bam-7218	885	51	proteins	protein	NOUN
bam-7218	885	52	mfn2	mfn2	PROPN
bam-7218	885	53	,	,	PUNCT
bam-7218	885	54	opa1	opa1	PROPN
bam-7218	885	55	and	and	CCONJ
bam-7218	885	56	profission	profission	NOUN
bam-7218	885	57	proteins	protein	NOUN
bam-7218	885	58	drp1	drp1	NOUN
bam-7218	885	59	and	and	CCONJ
bam-7218	885	60	fis1	fis1	NOUN
bam-7218	885	61	;	;	PUNCT
bam-7218	885	62	(	(	PUNCT
bam-7218	885	63	iii	iii	X
bam-7218	885	64	)	)	PUNCT
bam-7218	885	65	an	an	DET
bam-7218	885	66	increased	increase	VERB
bam-7218	885	67	phosphorylation	phosphorylation	NOUN
bam-7218	885	68	of	of	ADP
bam-7218	885	69	mtor	mtor	NOUN
bam-7218	885	70	compared	compare	VERB
bam-7218	885	71	to	to	ADP
bam-7218	885	72	control	control	NOUN
bam-7218	885	73	and	and	CCONJ
bam-7218	885	74	hu	hu	NOUN
bam-7218	885	75	mice	mouse	NOUN
bam-7218	885	76	;	;	PUNCT
bam-7218	885	77	(	(	PUNCT
bam-7218	885	78	iv	iv	X
bam-7218	885	79	)	)	PUNCT
bam-7218	885	80	a	a	DET
bam-7218	885	81	significant	significant	ADJ
bam-7218	885	82	persistent	persistent	ADJ
bam-7218	885	83	activation	activation	NOUN
bam-7218	885	84	of	of	ADP
bam-7218	885	85	catabolic	catabolic	ADJ
bam-7218	885	86	pathways	pathway	NOUN
bam-7218	885	87	.	.	PUNCT
bam-7218	886	1	the	the	DET
bam-7218	886	2	data	datum	NOUN
bam-7218	886	3	suggest	suggest	VERB
bam-7218	886	4	that	that	SCONJ
bam-7218	886	5	exercise	exercise	NOUN
bam-7218	886	6	training	training	NOUN
bam-7218	886	7	can	can	AUX
bam-7218	886	8	prevent	prevent	VERB
bam-7218	886	9	skeletal	skeletal	ADJ
bam-7218	886	10	muscle	muscle	NOUN
bam-7218	886	11	atrophy	atrophy	NOUN
bam-7218	886	12	due	due	ADP
bam-7218	886	13	to	to	ADP
bam-7218	886	14	acute	acute	ADJ
bam-7218	886	15	periods	period	NOUN
bam-7218	886	16	of	of	ADP
bam-7218	886	17	unloading	unloading	NOUN
bam-7218	886	18	by	by	ADP
bam-7218	886	19	modulating	modulate	VERB
bam-7218	886	20	mitochondrial	mitochondrial	ADJ
bam-7218	886	21	dynamics	dynamic	NOUN
bam-7218	886	22	.	.	PUNCT
bam-7218	887	1	p.09	p.09	PROPN
bam-7218	887	2	exercise	exercise	NOUN
bam-7218	887	3	role	role	NOUN
bam-7218	887	4	on	on	ADP
bam-7218	887	5	myotendinous	myotendinous	ADJ
bam-7218	887	6	junction	junction	NOUN
bam-7218	887	7	modulation	modulation	NOUN
bam-7218	887	8	:	:	PUNCT
bam-7218	887	9	a	a	DET
bam-7218	887	10	morphofunctional	morphofunctional	ADJ
bam-7218	887	11	study	study	NOUN
bam-7218	887	12	debora	debora	PROPN
bam-7218	887	13	burini	burini	PROPN
bam-7218	887	14	,	,	PUNCT
bam-7218	887	15	sara	sara	PROPN
bam-7218	887	16	salucci	salucci	PROPN
bam-7218	887	17	,	,	PUNCT
bam-7218	887	18	michela	michela	PROPN
bam-7218	887	19	battistelli	battistelli	PROPN
bam-7218	887	20	,	,	PUNCT
bam-7218	887	21	sabrina	sabrina	PROPN
bam-7218	887	22	burattini	burattini	PROPN
bam-7218	887	23	,	,	PUNCT
bam-7218	887	24	pietro	pietro	PROPN
bam-7218	887	25	gobbi	gobbi	PROPN
bam-7218	887	26	,	,	PUNCT
bam-7218	887	27	elisabetta	elisabetta	PROPN
bam-7218	887	28	falcieri	falcieri	PROPN
bam-7218	887	29	,	,	PUNCT
bam-7218	887	30	davide	davide	ADJ
bam-7218	887	31	curzi	curzi	NOUN
bam-7218	887	32	dept	dept	NOUN
bam-7218	887	33	of	of	ADP
bam-7218	887	34	biomolecular	biomolecular	ADJ
bam-7218	887	35	sciences	science	NOUN
bam-7218	887	36	,	,	PUNCT
bam-7218	887	37	university	university	NOUN
bam-7218	887	38	of	of	ADP
bam-7218	887	39	urbino	urbino	PROPN
bam-7218	887	40	carlo	carlo	PROPN
bam-7218	887	41	bo	bo	PROPN
bam-7218	887	42	,	,	PUNCT
bam-7218	887	43	italy	italy	PROPN
bam-7218	887	44	.	.	PUNCT
bam-7218	888	1	e	e	X
bam-7218	888	2	-	-	NOUN
bam-7218	888	3	mail	mail	NOUN
bam-7218	888	4	:	:	PUNCT
bam-7218	888	5	debora.burini@uniurb.it	debora.burini@uniurb.it	VERB
bam-7218	888	6	the	the	DET
bam-7218	888	7	muscle	muscle	NOUN
bam-7218	888	8	-	-	PUNCT
bam-7218	888	9	tendon	tendon	NOUN
bam-7218	888	10	interface	interface	NOUN
bam-7218	888	11	,	,	PUNCT
bam-7218	888	12	called	call	VERB
bam-7218	888	13	myotendinous	myotendinous	ADJ
bam-7218	888	14	junction	junction	NOUN
bam-7218	888	15	(	(	PUNCT
bam-7218	888	16	mtj	mtj	NOUN
bam-7218	888	17	)	)	PUNCT
bam-7218	888	18	,	,	PUNCT
bam-7218	888	19	is	be	AUX
bam-7218	888	20	the	the	DET
bam-7218	888	21	key	key	ADJ
bam-7218	888	22	anatomical	anatomical	ADJ
bam-7218	888	23	area	area	NOUN
bam-7218	888	24	through	through	ADP
bam-7218	888	25	which	which	PRON
bam-7218	888	26	the	the	DET
bam-7218	888	27	contractile	contractile	NOUN
bam-7218	888	28	strength	strength	NOUN
bam-7218	888	29	can	can	AUX
bam-7218	888	30	be	be	AUX
bam-7218	888	31	transmitted	transmit	VERB
bam-7218	888	32	between	between	ADP
bam-7218	888	33	tissues	tissue	NOUN
bam-7218	888	34	.	.	PUNCT
bam-7218	889	1	the	the	DET
bam-7218	889	2	mtj	mtj	NOUN
bam-7218	889	3	is	be	AUX
bam-7218	889	4	a	a	DET
bam-7218	889	5	dynamic	dynamic	ADJ
bam-7218	889	6	interface	interface	NOUN
bam-7218	889	7	and	and	CCONJ
bam-7218	889	8	different	different	ADJ
bam-7218	889	9	physiological	physiological	ADJ
bam-7218	889	10	and	and	CCONJ
bam-7218	889	11	pathological	pathological	ADJ
bam-7218	889	12	conditions	condition	NOUN
bam-7218	889	13	may	may	AUX
bam-7218	889	14	induce	induce	VERB
bam-7218	889	15	morphofunctional	morphofunctional	ADJ
bam-7218	889	16	changes	change	NOUN
bam-7218	889	17	.	.	PUNCT
bam-7218	890	1	mechanical	mechanical	ADJ
bam-7218	890	2	loading	loading	NOUN
bam-7218	890	3	seems	seem	VERB
bam-7218	890	4	to	to	PART
bam-7218	890	5	have	have	VERB
bam-7218	890	6	a	a	DET
bam-7218	890	7	key	key	ADJ
bam-7218	890	8	role	role	NOUN
bam-7218	890	9	in	in	ADP
bam-7218	890	10	the	the	DET
bam-7218	890	11	mtj	mtj	NOUN
bam-7218	890	12	plasticity	plasticity	NOUN
bam-7218	890	13	.	.	PUNCT
bam-7218	891	1	in	in	ADP
bam-7218	891	2	fact	fact	NOUN
bam-7218	891	3	,	,	PUNCT
bam-7218	891	4	mtj	mtj	NOUN
bam-7218	891	5	may	may	AUX
bam-7218	891	6	reduce	reduce	VERB
bam-7218	891	7	or	or	CCONJ
bam-7218	891	8	increase	increase	VERB
bam-7218	891	9	its	its	PRON
bam-7218	891	10	complexity	complexity	NOUN
bam-7218	891	11	and	and	CCONJ
bam-7218	891	12	the	the	DET
bam-7218	891	13	contact	contact	NOUN
bam-7218	891	14	surface	surface	NOUN
bam-7218	891	15	between	between	ADP
bam-7218	891	16	tissues	tissue	NOUN
bam-7218	891	17	,	,	PUNCT
bam-7218	891	18	in	in	ADP
bam-7218	891	19	relationship	relationship	NOUN
bam-7218	891	20	to	to	PART
bam-7218	891	21	muscle	muscle	VERB
bam-7218	891	22	atrophy	atrophy	NOUN
bam-7218	891	23	and	and	CCONJ
bam-7218	891	24	exercise	exercise	NOUN
bam-7218	891	25	protocols	protocol	NOUN
bam-7218	891	26	,	,	PUNCT
bam-7218	891	27	respectively	respectively	ADV
bam-7218	891	28	.	.	PUNCT
bam-7218	892	1	the	the	DET
bam-7218	892	2	molecular	molecular	ADJ
bam-7218	892	3	mechanisms	mechanism	NOUN
bam-7218	892	4	and	and	CCONJ
bam-7218	892	5	the	the	DET
bam-7218	892	6	different	different	ADJ
bam-7218	892	7	stages	stage	NOUN
bam-7218	892	8	of	of	ADP
bam-7218	892	9	these	these	DET
bam-7218	892	10	morphofunctional	morphofunctional	ADJ
bam-7218	892	11	adaptations	adaptation	NOUN
bam-7218	892	12	need	need	VERB
bam-7218	892	13	to	to	PART
bam-7218	892	14	be	be	AUX
bam-7218	892	15	further	far	ADV
bam-7218	892	16	deepened	deepen	VERB
bam-7218	892	17	.	.	PUNCT
bam-7218	893	1	an	an	DET
bam-7218	893	2	interesting	interesting	ADJ
bam-7218	893	3	high	high	ADJ
bam-7218	893	4	presence	presence	NOUN
bam-7218	893	5	of	of	ADP
bam-7218	893	6	tenocytes	tenocyte	NOUN
bam-7218	893	7	near	near	ADP
bam-7218	893	8	the	the	DET
bam-7218	893	9	mtj	mtj	NOUN
bam-7218	893	10	has	have	AUX
bam-7218	893	11	been	be	AUX
bam-7218	893	12	revealed	reveal	VERB
bam-7218	893	13	by	by	ADP
bam-7218	893	14	means	mean	NOUN
bam-7218	893	15	of	of	ADP
bam-7218	893	16	transmission	transmission	NOUN
bam-7218	893	17	electron	electron	NOUN
bam-7218	893	18	microscopy	microscopy	NOUN
bam-7218	893	19	.	.	PUNCT
bam-7218	894	1	these	these	DET
bam-7218	894	2	cells	cell	NOUN
bam-7218	894	3	showed	show	VERB
bam-7218	894	4	an	an	DET
bam-7218	894	5	increased	increase	VERB
bam-7218	894	6	amount	amount	NOUN
bam-7218	894	7	of	of	ADP
bam-7218	894	8	rough	rough	ADJ
bam-7218	894	9	endoplasmic	endoplasmic	ADJ
bam-7218	894	10	reticulum	reticulum	NOUN
bam-7218	894	11	in	in	ADP
bam-7218	894	12	exercised	exercised	ADJ
bam-7218	894	13	rats	rat	NOUN
bam-7218	894	14	,	,	PUNCT
bam-7218	894	15	compared	compare	VERB
bam-7218	894	16	to	to	ADP
bam-7218	894	17	sedentary	sedentary	ADJ
bam-7218	894	18	ones	one	NOUN
bam-7218	894	19	.	.	PUNCT
bam-7218	895	1	in	in	ADP
bam-7218	895	2	literature	literature	NOUN
bam-7218	895	3	,	,	PUNCT
bam-7218	895	4	the	the	DET
bam-7218	895	5	exercise	exercise	NOUN
bam-7218	895	6	ability	ability	NOUN
bam-7218	895	7	to	to	PART
bam-7218	895	8	increase	increase	VERB
bam-7218	895	9	tenocyte	tenocyte	NOUN
bam-7218	895	10	rough	rough	ADJ
bam-7218	895	11	endoplasmic	endoplasmic	ADJ
bam-7218	895	12	reticulum	reticulum	NOUN
bam-7218	895	13	amount	amount	NOUN
bam-7218	895	14	has	have	AUX
bam-7218	895	15	already	already	ADV
bam-7218	895	16	been	be	AUX
bam-7218	895	17	mailto:fra.bonazza@gmail.com	mailto:fra.bonazza@gmail.com	X
bam-7218	895	18	mailto:lorenza.brocca@unipv.it	mailto:lorenza.brocca@unipv.it	PROPN
bam-7218	895	19	mailto:debora.burini@uniurb.it	mailto:debora.burini@uniurb.it	PROPN
bam-7218	895	20	14	14	NUM
bam-7218	895	21	th	th	NOUN
bam-7218	895	22	iiim	iiim	NOUN
bam-7218	895	23	meeting	meeting	NOUN
bam-7218	895	24	,	,	PUNCT
bam-7218	895	25	assisi	assisi	PROPN
bam-7218	895	26	,	,	PUNCT
bam-7218	895	27	italy	italy	PROPN
bam-7218	895	28	october	october	PROPN
bam-7218	895	29	12	12	NUM
bam-7218	895	30	-	-	SYM
bam-7218	895	31	15	15	NUM
bam-7218	895	32	2017	2017	NUM
bam-7218	895	33	eur	eur	PROPN
bam-7218	895	34	j	j	PROPN
bam-7218	895	35	transl	transl	PROPN
bam-7218	895	36	myol	myol	ADV
bam-7218	895	37	27	27	NUM
bam-7218	895	38	(	(	PUNCT
bam-7218	895	39	4	4	NUM
bam-7218	895	40	):	):	SYM
bam-7218	895	41	185	185	NUM
bam-7218	895	42	-	-	SYM
bam-7218	895	43	224	224	NUM
bam-7218	895	44	212	212	NUM
bam-7218	895	45	demonstrated	demonstrate	VERB
bam-7218	895	46	.	.	PUNCT
bam-7218	896	1	this	this	DET
bam-7218	896	2	increase	increase	NOUN
bam-7218	896	3	has	have	AUX
bam-7218	896	4	been	be	AUX
bam-7218	896	5	associated	associate	VERB
bam-7218	896	6	with	with	ADP
bam-7218	896	7	enhanced	enhanced	ADJ
bam-7218	896	8	production	production	NOUN
bam-7218	896	9	of	of	ADP
bam-7218	896	10	collagen	collagen	NOUN
bam-7218	896	11	fibers	fiber	NOUN
bam-7218	896	12	and	and	CCONJ
bam-7218	896	13	extracellular	extracellular	ADJ
bam-7218	896	14	matrix	matrix	NOUN
bam-7218	896	15	components	component	NOUN
bam-7218	896	16	.	.	PUNCT
bam-7218	897	1	morphological	morphological	ADJ
bam-7218	897	2	observations	observation	NOUN
bam-7218	897	3	of	of	ADP
bam-7218	897	4	tenocyte	tenocyte	PROPN
bam-7218	897	5	behaviour	behaviour	NOUN
bam-7218	897	6	near	near	ADP
bam-7218	897	7	mtj	mtj	NOUN
bam-7218	897	8	reveal	reveal	VERB
bam-7218	897	9	their	their	PRON
bam-7218	897	10	activation	activation	NOUN
bam-7218	897	11	following	follow	VERB
bam-7218	897	12	exercise	exercise	NOUN
bam-7218	897	13	protocol	protocol	NOUN
bam-7218	897	14	,	,	PUNCT
bam-7218	897	15	suggesting	suggest	VERB
bam-7218	897	16	a	a	DET
bam-7218	897	17	key	key	ADJ
bam-7218	897	18	role	role	NOUN
bam-7218	897	19	of	of	ADP
bam-7218	897	20	these	these	DET
bam-7218	897	21	cells	cell	NOUN
bam-7218	897	22	in	in	ADP
bam-7218	897	23	the	the	DET
bam-7218	897	24	modulation	modulation	NOUN
bam-7218	897	25	of	of	ADP
bam-7218	897	26	mtj	mtj	NOUN
bam-7218	897	27	morphology	morphology	NOUN
bam-7218	897	28	.	.	PUNCT
bam-7218	898	1	p.10	p.10	ADP
bam-7218	898	2	electrical	electrical	ADJ
bam-7218	898	3	pulse	pulse	NOUN
bam-7218	898	4	-	-	PUNCT
bam-7218	898	5	stimulation	stimulation	NOUN
bam-7218	898	6	of	of	ADP
bam-7218	898	7	myotubes	myotube	NOUN
bam-7218	898	8	induces	induce	VERB
bam-7218	898	9	extracellular	extracellular	ADJ
bam-7218	898	10	vesicle	vesicle	NOUN
bam-7218	898	11	release	release	NOUN
bam-7218	898	12	paola	paola	PROPN
bam-7218	898	13	ceccaroli	ceccaroli	PROPN
bam-7218	898	14	,	,	PUNCT
bam-7218	898	15	michele	michele	PROPN
bam-7218	898	16	guescini	guescini	PROPN
bam-7218	898	17	,	,	PUNCT
bam-7218	898	18	serena	serena	PROPN
bam-7218	898	19	maggio	maggio	PROPN
bam-7218	898	20	,	,	PUNCT
bam-7218	898	21	giosuè	giosuè	PROPN
bam-7218	898	22	annibalini	annibalini	PROPN
bam-7218	898	23	,	,	PUNCT
bam-7218	898	24	emanuela	emanuela	PROPN
bam-7218	898	25	polidori	polidori	PROPN
bam-7218	898	26	,	,	PUNCT
bam-7218	898	27	francesco	francesco	PROPN
bam-7218	898	28	lucertini	lucertini	PROPN
bam-7218	898	29	,	,	PUNCT
bam-7218	898	30	vilberto	vilberto	PROPN
bam-7218	898	31	stocchi	stocchi	PROPN
bam-7218	898	32	dept	dept	PROPN
bam-7218	898	33	of	of	ADP
bam-7218	898	34	biomolecular	biomolecular	ADJ
bam-7218	898	35	sciences	science	NOUN
bam-7218	898	36	,	,	PUNCT
bam-7218	898	37	university	university	NOUN
bam-7218	898	38	of	of	ADP
bam-7218	898	39	urbino	urbino	PROPN
bam-7218	898	40	carlo	carlo	PROPN
bam-7218	898	41	bo	bo	PROPN
bam-7218	898	42	,	,	PUNCT
bam-7218	898	43	italy	italy	PROPN
bam-7218	898	44	.	.	PUNCT
bam-7218	899	1	e	e	X
bam-7218	899	2	-	-	NOUN
bam-7218	899	3	mail	mail	NOUN
bam-7218	899	4	:	:	PUNCT
bam-7218	899	5	paola.ceccaroli@uniurb.it	paola.ceccaroli@uniurb.it	NOUN
bam-7218	899	6	regular	regular	ADJ
bam-7218	899	7	exercise	exercise	NOUN
bam-7218	899	8	has	have	AUX
bam-7218	899	9	emerged	emerge	VERB
bam-7218	899	10	as	as	ADP
bam-7218	899	11	an	an	DET
bam-7218	899	12	effective	effective	ADJ
bam-7218	899	13	strategy	strategy	NOUN
bam-7218	899	14	to	to	PART
bam-7218	899	15	prevent	prevent	VERB
bam-7218	899	16	and	and	CCONJ
bam-7218	899	17	treat	treat	VERB
bam-7218	899	18	metabolic	metabolic	NOUN
bam-7218	899	19	diseases	disease	NOUN
bam-7218	899	20	.	.	PUNCT
bam-7218	900	1	the	the	DET
bam-7218	900	2	beneficial	beneficial	ADJ
bam-7218	900	3	effects	effect	NOUN
bam-7218	900	4	of	of	ADP
bam-7218	900	5	exercise	exercise	NOUN
bam-7218	900	6	can	can	AUX
bam-7218	900	7	be	be	AUX
bam-7218	900	8	easily	easily	ADV
bam-7218	900	9	observed	observe	VERB
bam-7218	900	10	in	in	ADP
bam-7218	900	11	muscle	muscle	NOUN
bam-7218	900	12	tissue	tissue	NOUN
bam-7218	900	13	but	but	CCONJ
bam-7218	900	14	also	also	ADV
bam-7218	900	15	on	on	ADP
bam-7218	900	16	a	a	DET
bam-7218	900	17	variety	variety	NOUN
bam-7218	900	18	of	of	ADP
bam-7218	900	19	distant	distant	ADJ
bam-7218	900	20	organs	organ	NOUN
bam-7218	900	21	,	,	PUNCT
bam-7218	900	22	such	such	ADJ
bam-7218	900	23	as	as	ADP
bam-7218	900	24	brain	brain	NOUN
bam-7218	900	25	,	,	PUNCT
bam-7218	900	26	heart	heart	NOUN
bam-7218	900	27	,	,	PUNCT
bam-7218	900	28	lungs	lung	NOUN
bam-7218	900	29	,	,	PUNCT
bam-7218	900	30	adipose	adipose	NOUN
bam-7218	900	31	tissue	tissue	NOUN
bam-7218	900	32	and	and	CCONJ
bam-7218	900	33	liver	liver	NOUN
bam-7218	900	34	,	,	PUNCT
bam-7218	900	35	thus	thus	ADV
bam-7218	900	36	suggesting	suggest	VERB
bam-7218	900	37	that	that	PRON
bam-7218	900	38	muscle	muscle	NOUN
bam-7218	900	39	has	have	VERB
bam-7218	900	40	endocrine	endocrine	ADJ
bam-7218	900	41	activity	activity	NOUN
bam-7218	900	42	.	.	PUNCT
bam-7218	901	1	a	a	DET
bam-7218	901	2	growing	grow	VERB
bam-7218	901	3	body	body	NOUN
bam-7218	901	4	of	of	ADP
bam-7218	901	5	evidence	evidence	NOUN
bam-7218	901	6	shows	show	VERB
bam-7218	901	7	that	that	SCONJ
bam-7218	901	8	contracting	contract	VERB
bam-7218	901	9	muscle	muscle	NOUN
bam-7218	901	10	releases	release	VERB
bam-7218	901	11	cytokines	cytokine	NOUN
bam-7218	901	12	with	with	ADP
bam-7218	901	13	autocrine	autocrine	NOUN
bam-7218	901	14	,	,	PUNCT
bam-7218	901	15	paracrine	paracrine	NOUN
bam-7218	901	16	and	and	CCONJ
bam-7218	901	17	endocrine	endocrine	NOUN
bam-7218	901	18	functions	function	NOUN
bam-7218	901	19	;	;	PUNCT
bam-7218	901	20	hence	hence	ADV
bam-7218	901	21	,	,	PUNCT
bam-7218	901	22	they	they	PRON
bam-7218	901	23	are	be	AUX
bam-7218	901	24	now	now	ADV
bam-7218	901	25	recognized	recognize	VERB
bam-7218	901	26	as	as	ADP
bam-7218	901	27	myokines	myokine	NOUN
bam-7218	901	28	.	.	PUNCT
bam-7218	902	1	in	in	ADP
bam-7218	902	2	the	the	DET
bam-7218	902	3	last	last	ADJ
bam-7218	902	4	years	year	NOUN
bam-7218	902	5	a	a	DET
bam-7218	902	6	new	new	ADJ
bam-7218	902	7	mechanism	mechanism	NOUN
bam-7218	902	8	for	for	ADP
bam-7218	902	9	intercellular	intercellular	ADJ
bam-7218	902	10	communication	communication	NOUN
bam-7218	902	11	mediated	mediate	VERB
bam-7218	902	12	by	by	ADP
bam-7218	902	13	extracellular	extracellular	ADJ
bam-7218	902	14	vesicles	vesicle	NOUN
bam-7218	902	15	(	(	PUNCT
bam-7218	902	16	evs	evs	NOUN
bam-7218	902	17	)	)	PUNCT
bam-7218	902	18	has	have	AUX
bam-7218	902	19	emerged	emerge	VERB
bam-7218	902	20	.	.	PUNCT
bam-7218	903	1	evs	evs	NOUN
bam-7218	903	2	are	be	AUX
bam-7218	903	3	spherical	spherical	ADJ
bam-7218	903	4	structures	structure	NOUN
bam-7218	903	5	bound	bind	VERB
bam-7218	903	6	by	by	ADP
bam-7218	903	7	a	a	DET
bam-7218	903	8	lipid	lipid	NOUN
bam-7218	903	9	bilayer	bilayer	NOUN
bam-7218	903	10	,	,	PUNCT
bam-7218	903	11	which	which	PRON
bam-7218	903	12	is	be	AUX
bam-7218	903	13	similar	similar	ADJ
bam-7218	903	14	in	in	ADP
bam-7218	903	15	composition	composition	NOUN
bam-7218	903	16	to	to	ADP
bam-7218	903	17	the	the	DET
bam-7218	903	18	cell	cell	NOUN
bam-7218	903	19	membrane	membrane	NOUN
bam-7218	903	20	from	from	ADP
bam-7218	903	21	which	which	PRON
bam-7218	903	22	the	the	DET
bam-7218	903	23	vesicle	vesicle	NOUN
bam-7218	903	24	originated	originate	VERB
bam-7218	903	25	.	.	PUNCT
bam-7218	904	1	among	among	ADP
bam-7218	904	2	these	these	PRON
bam-7218	904	3	,	,	PUNCT
bam-7218	904	4	exosomes	exosome	NOUN
bam-7218	904	5	are	be	AUX
bam-7218	904	6	welldefined	welldefine	VERB
bam-7218	904	7	vesicles	vesicle	NOUN
bam-7218	904	8	(	(	PUNCT
bam-7218	904	9	ranging	range	VERB
bam-7218	904	10	in	in	ADP
bam-7218	904	11	size	size	NOUN
bam-7218	904	12	from	from	ADP
bam-7218	904	13	40	40	NUM
bam-7218	904	14	to	to	PART
bam-7218	904	15	100	100	NUM
bam-7218	904	16	nm	nm	NOUN
bam-7218	904	17	)	)	PUNCT
bam-7218	904	18	that	that	PRON
bam-7218	904	19	originate	originate	VERB
bam-7218	904	20	from	from	ADP
bam-7218	904	21	multivesicular	multivesicular	ADJ
bam-7218	904	22	bodies	body	NOUN
bam-7218	904	23	.	.	PUNCT
bam-7218	905	1	in	in	ADP
bam-7218	905	2	order	order	NOUN
bam-7218	905	3	to	to	PART
bam-7218	905	4	understand	understand	VERB
bam-7218	905	5	ev	ev	ADP
bam-7218	905	6	release	release	NOUN
bam-7218	905	7	in	in	ADP
bam-7218	905	8	working	work	VERB
bam-7218	905	9	skeletal	skeletal	ADJ
bam-7218	905	10	muscles	muscle	NOUN
bam-7218	905	11	,	,	PUNCT
bam-7218	905	12	we	we	PRON
bam-7218	905	13	took	take	VERB
bam-7218	905	14	advantage	advantage	NOUN
bam-7218	905	15	of	of	ADP
bam-7218	905	16	electrical	electrical	ADJ
bam-7218	905	17	pulse	pulse	NOUN
bam-7218	905	18	stimulated	stimulate	VERB
bam-7218	905	19	(	(	PUNCT
bam-7218	905	20	eps	eps	PROPN
bam-7218	905	21	)	)	PUNCT
bam-7218	905	22	c2c12	c2c12	NOUN
bam-7218	905	23	myotube	myotube	NOUN
bam-7218	905	24	model	model	NOUN
bam-7218	905	25	to	to	PART
bam-7218	905	26	investigate	investigate	VERB
bam-7218	905	27	the	the	DET
bam-7218	905	28	characteristics	characteristic	NOUN
bam-7218	905	29	of	of	ADP
bam-7218	905	30	secreted	secrete	VERB
bam-7218	905	31	evs	evs	NOUN
bam-7218	905	32	in	in	ADP
bam-7218	905	33	response	response	NOUN
bam-7218	905	34	to	to	ADP
bam-7218	905	35	eps	eps	VERB
bam-7218	905	36	-	-	PUNCT
bam-7218	905	37	evoked	evoke	VERB
bam-7218	905	38	contractile	contractile	NOUN
bam-7218	905	39	activity	activity	NOUN
bam-7218	905	40	.	.	PUNCT
bam-7218	906	1	five	five	NUM
bam-7218	906	2	to	to	PART
bam-7218	906	3	six	six	NUM
bam-7218	906	4	days	day	NOUN
bam-7218	906	5	after	after	ADP
bam-7218	906	6	differentiation	differentiation	NOUN
bam-7218	906	7	,	,	PUNCT
bam-7218	906	8	c2c12	c2c12	PROPN
bam-7218	906	9	myotubes	myotube	NOUN
bam-7218	906	10	were	be	AUX
bam-7218	906	11	placed	place	VERB
bam-7218	906	12	in	in	ADP
bam-7218	906	13	a	a	DET
bam-7218	906	14	chamber	chamber	NOUN
bam-7218	906	15	for	for	ADP
bam-7218	906	16	electrical	electrical	ADJ
bam-7218	906	17	stimulation	stimulation	NOUN
bam-7218	906	18	.	.	PUNCT
bam-7218	907	1	eps	eps	PROPN
bam-7218	907	2	was	be	AUX
bam-7218	907	3	carried	carry	VERB
bam-7218	907	4	out	out	ADP
bam-7218	907	5	as	as	SCONJ
bam-7218	907	6	follows	follow	VERB
bam-7218	907	7	:	:	PUNCT
bam-7218	907	8	6	6	NUM
bam-7218	907	9	hours	hour	NOUN
bam-7218	907	10	stimulation	stimulation	NOUN
bam-7218	907	11	with	with	ADP
bam-7218	907	12	continuous	continuous	ADJ
bam-7218	907	13	10	10	NUM
bam-7218	907	14	-	-	PUNCT
bam-7218	907	15	ms	ms	NOUN
bam-7218	907	16	duration	duration	NOUN
bam-7218	907	17	pulse	pulse	NOUN
bam-7218	907	18	of	of	ADP
bam-7218	907	19	40v/60	40v/60	NUM
bam-7218	907	20	mm	mm	NOUN
bam-7218	907	21	voltage	voltage	NOUN
bam-7218	907	22	and	and	CCONJ
bam-7218	907	23	1	1	NUM
bam-7218	907	24	hz	hz	VERB
bam-7218	907	25	frequency	frequency	NOUN
bam-7218	907	26	.	.	PUNCT
bam-7218	908	1	conditioned	condition	VERB
bam-7218	908	2	medium	medium	NOUN
bam-7218	908	3	was	be	AUX
bam-7218	908	4	first	first	ADV
bam-7218	908	5	cleared	clear	VERB
bam-7218	908	6	and	and	CCONJ
bam-7218	908	7	then	then	ADV
bam-7218	908	8	exosomes	exosome	NOUN
bam-7218	908	9	were	be	AUX
bam-7218	908	10	collected	collect	VERB
bam-7218	908	11	using	use	VERB
bam-7218	908	12	standard	standard	ADJ
bam-7218	908	13	ultracentrifugation	ultracentrifugation	NOUN
bam-7218	908	14	protocol	protocol	NOUN
bam-7218	908	15	.	.	PUNCT
bam-7218	909	1	eps	eps	PROPN
bam-7218	909	2	applied	apply	VERB
bam-7218	909	3	for	for	ADP
bam-7218	909	4	6	6	NUM
bam-7218	909	5	hours	hour	NOUN
bam-7218	909	6	resulted	result	VERB
bam-7218	909	7	in	in	ADP
bam-7218	909	8	contraction	contraction	NOUN
bam-7218	909	9	of	of	ADP
bam-7218	909	10	the	the	DET
bam-7218	909	11	myotubes	myotube	NOUN
bam-7218	909	12	and	and	CCONJ
bam-7218	909	13	no	no	DET
bam-7218	909	14	other	other	ADJ
bam-7218	909	15	dramatic	dramatic	ADJ
bam-7218	909	16	morphological	morphological	ADJ
bam-7218	909	17	changes	change	NOUN
bam-7218	909	18	were	be	AUX
bam-7218	909	19	detected	detect	VERB
bam-7218	909	20	.	.	PUNCT
bam-7218	910	1	although	although	SCONJ
bam-7218	910	2	eps	eps	PROPN
bam-7218	910	3	promoted	promote	VERB
bam-7218	910	4	the	the	DET
bam-7218	910	5	contraction	contraction	NOUN
bam-7218	910	6	of	of	ADP
bam-7218	910	7	c2c12	c2c12	PROPN
bam-7218	910	8	myotubes	myotube	NOUN
bam-7218	910	9	,	,	PUNCT
bam-7218	910	10	it	it	PRON
bam-7218	910	11	did	do	AUX
bam-7218	910	12	not	not	PART
bam-7218	910	13	appear	appear	VERB
bam-7218	910	14	to	to	PART
bam-7218	910	15	induce	induce	VERB
bam-7218	910	16	cell	cell	NOUN
bam-7218	910	17	death	death	NOUN
bam-7218	910	18	,	,	PUNCT
bam-7218	910	19	as	as	SCONJ
bam-7218	910	20	assessed	assess	VERB
bam-7218	910	21	by	by	ADP
bam-7218	910	22	ldh	ldh	PROPN
bam-7218	910	23	release	release	NOUN
bam-7218	910	24	,	,	PUNCT
bam-7218	910	25	since	since	SCONJ
bam-7218	910	26	cytotoxicity	cytotoxicity	NOUN
bam-7218	910	27	did	do	AUX
bam-7218	910	28	not	not	PART
bam-7218	910	29	differ	differ	VERB
bam-7218	910	30	significantly	significantly	ADV
bam-7218	910	31	between	between	ADP
bam-7218	910	32	cell	cell	NOUN
bam-7218	910	33	cultures	culture	NOUN
bam-7218	910	34	with	with	ADP
bam-7218	910	35	vs.	vs.	NOUN
bam-7218	910	36	without	without	ADP
bam-7218	910	37	eps	eps	PROPN
bam-7218	910	38	treatment	treatment	NOUN
bam-7218	910	39	.	.	PUNCT
bam-7218	911	1	the	the	DET
bam-7218	911	2	immunoblotting	immunoblotte	VERB
bam-7218	911	3	results	result	NOUN
bam-7218	911	4	showed	show	VERB
bam-7218	911	5	that	that	DET
bam-7218	911	6	phosphorylation	phosphorylation	NOUN
bam-7218	911	7	of	of	ADP
bam-7218	911	8	amp	amp	NOUN
bam-7218	911	9	-	-	PUNCT
bam-7218	911	10	activated	activate	VERB
bam-7218	911	11	protein	protein	NOUN
bam-7218	911	12	kinase	kinase	NOUN
bam-7218	911	13	(	(	PUNCT
bam-7218	911	14	ampk	ampk	PROPN
bam-7218	911	15	;	;	PUNCT
bam-7218	911	16	thr172	thr172	PROPN
bam-7218	911	17	)	)	PUNCT
bam-7218	911	18	,	,	PUNCT
bam-7218	911	19	and	and	CCONJ
bam-7218	911	20	erk1/2	erk1/2	PROPN
bam-7218	911	21	(	(	PUNCT
bam-7218	911	22	thr202	thr202	PROPN
bam-7218	911	23	/	/	SYM
bam-7218	911	24	tyr204	tyr204	PROPN
bam-7218	911	25	)	)	PUNCT
bam-7218	911	26	was	be	AUX
bam-7218	911	27	slightly	slightly	ADV
bam-7218	911	28	but	but	CCONJ
bam-7218	911	29	significantly	significantly	ADV
bam-7218	911	30	increased	increase	VERB
bam-7218	911	31	by	by	ADP
bam-7218	911	32	6	6	NUM
bam-7218	911	33	-	-	PUNCT
bam-7218	911	34	h	h	NOUN
bam-7218	911	35	eps	eps	PROPN
bam-7218	911	36	.	.	PROPN
bam-7218	912	1	then	then	ADV
bam-7218	912	2	we	we	PRON
bam-7218	912	3	examined	examine	VERB
bam-7218	912	4	whether	whether	SCONJ
bam-7218	912	5	eps	eps	NOUN
bam-7218	912	6	-	-	PUNCT
bam-7218	912	7	evoked	evoke	VERB
bam-7218	912	8	contraction	contraction	NOUN
bam-7218	912	9	results	result	NOUN
bam-7218	912	10	in	in	ADP
bam-7218	912	11	cytokine	cytokine	NOUN
bam-7218	912	12	and	and	CCONJ
bam-7218	912	13	mirnas	mirna	NOUN
bam-7218	912	14	modulation	modulation	NOUN
bam-7218	912	15	and	and	CCONJ
bam-7218	912	16	,	,	PUNCT
bam-7218	912	17	as	as	SCONJ
bam-7218	912	18	expected	expect	VERB
bam-7218	912	19	,	,	PUNCT
bam-7218	912	20	il-6	il-6	CCONJ
bam-7218	912	21	mrna	mrna	NOUN
bam-7218	912	22	and	and	CCONJ
bam-7218	912	23	mir-146a	mir-146a	ADJ
bam-7218	912	24	expression	expression	NOUN
bam-7218	912	25	were	be	AUX
bam-7218	912	26	remarkably	remarkably	ADV
bam-7218	912	27	upregulated	upregulate	VERB
bam-7218	912	28	in	in	ADP
bam-7218	912	29	contractile	contractile	NOUN
bam-7218	912	30	myotubes	myotube	NOUN
bam-7218	912	31	.	.	PUNCT
bam-7218	913	1	nanoparticle	nanoparticle	NOUN
bam-7218	913	2	tracking	tracking	NOUN
bam-7218	913	3	assay	assay	PROPN
bam-7218	913	4	showed	show	VERB
bam-7218	913	5	that	that	SCONJ
bam-7218	913	6	eps	eps	NOUN
bam-7218	913	7	-	-	PUNCT
bam-7218	913	8	induced	induce	VERB
bam-7218	913	9	contraction	contraction	NOUN
bam-7218	913	10	determined	determine	VERB
bam-7218	913	11	an	an	DET
bam-7218	913	12	increased	increase	VERB
bam-7218	913	13	release	release	NOUN
bam-7218	913	14	of	of	ADP
bam-7218	913	15	evs	evs	NOUN
bam-7218	913	16	in	in	ADP
bam-7218	913	17	the	the	DET
bam-7218	913	18	medium	medium	NOUN
bam-7218	913	19	compared	compare	VERB
bam-7218	913	20	with	with	ADP
bam-7218	913	21	control	control	NOUN
bam-7218	913	22	.	.	PUNCT
bam-7218	914	1	these	these	DET
bam-7218	914	2	data	datum	NOUN
bam-7218	914	3	were	be	AUX
bam-7218	914	4	further	far	ADV
bam-7218	914	5	corroborated	corroborate	VERB
bam-7218	914	6	by	by	ADP
bam-7218	914	7	western	western	ADJ
bam-7218	914	8	blot	blot	NOUN
bam-7218	914	9	analysis	analysis	NOUN
bam-7218	914	10	of	of	ADP
bam-7218	914	11	purified	purified	ADJ
bam-7218	914	12	evs	evs	NOUN
bam-7218	914	13	using	use	VERB
bam-7218	914	14	antibodies	antibody	NOUN
bam-7218	914	15	against	against	ADP
bam-7218	914	16	well	well	ADV
bam-7218	914	17	-	-	PUNCT
bam-7218	914	18	defined	define	VERB
bam-7218	914	19	exosomes	exosome	NOUN
bam-7218	914	20	markers	marker	NOUN
bam-7218	914	21	(	(	PUNCT
bam-7218	914	22	tsg101	tsg101	PROPN
bam-7218	914	23	and	and	CCONJ
bam-7218	914	24	alix	alix	PROPN
bam-7218	914	25	)	)	PUNCT
bam-7218	914	26	.	.	PUNCT
bam-7218	915	1	taken	take	VERB
bam-7218	915	2	together	together	ADV
bam-7218	915	3	,	,	PUNCT
bam-7218	915	4	these	these	DET
bam-7218	915	5	findings	finding	NOUN
bam-7218	915	6	indicate	indicate	VERB
bam-7218	915	7	that	that	SCONJ
bam-7218	915	8	myotube	myotube	NOUN
bam-7218	915	9	contraction	contraction	NOUN
bam-7218	915	10	may	may	AUX
bam-7218	915	11	induce	induce	VERB
bam-7218	915	12	the	the	DET
bam-7218	915	13	active	active	ADJ
bam-7218	915	14	release	release	NOUN
bam-7218	915	15	of	of	ADP
bam-7218	915	16	membrane	membrane	NOUN
bam-7218	915	17	vesicles	vesicle	NOUN
bam-7218	915	18	,	,	PUNCT
bam-7218	915	19	in	in	ADP
bam-7218	915	20	particular	particular	ADJ
bam-7218	915	21	exosomes	exosome	NOUN
bam-7218	915	22	potentially	potentially	ADV
bam-7218	915	23	involved	involve	VERB
bam-7218	915	24	in	in	ADP
bam-7218	915	25	mediating	mediate	VERB
bam-7218	915	26	communication	communication	NOUN
bam-7218	915	27	between	between	ADP
bam-7218	915	28	muscle	muscle	NOUN
bam-7218	915	29	and	and	CCONJ
bam-7218	915	30	other	other	ADJ
bam-7218	915	31	organs	organ	NOUN
bam-7218	915	32	.	.	PUNCT
bam-7218	916	1	supported	support	VERB
bam-7218	916	2	by	by	ADP
bam-7218	916	3	:	:	PUNCT
bam-7218	916	4	italian	italian	ADJ
bam-7218	916	5	ministry	ministry	PROPN
bam-7218	916	6	of	of	ADP
bam-7218	916	7	health	health	PROPN
bam-7218	916	8	:	:	PUNCT
bam-7218	916	9	gr-2011	gr-2011	PROPN
bam-7218	916	10	-	-	PUNCT
bam-7218	916	11	02350264	02350264	NUM
bam-7218	916	12	to	to	ADP
bam-7218	916	13	mg	mg	PROPN
bam-7218	916	14	.	.	PUNCT
bam-7218	917	1	p.11	p.11	ADJ
bam-7218	917	2	rage	rage	NOUN
bam-7218	917	3	and	and	CCONJ
bam-7218	917	4	its	its	PRON
bam-7218	917	5	ligands	ligand	NOUN
bam-7218	917	6	,	,	PUNCT
bam-7218	917	7	s100b	s100b	PROPN
bam-7218	917	8	and	and	CCONJ
bam-7218	917	9	hmgb1	hmgb1	PROPN
bam-7218	917	10	,	,	PUNCT
bam-7218	917	11	are	be	AUX
bam-7218	917	12	molecular	molecular	ADJ
bam-7218	917	13	determinants	determinant	NOUN
bam-7218	917	14	of	of	ADP
bam-7218	917	15	cancer	cancer	NOUN
bam-7218	917	16	-	-	PUNCT
bam-7218	917	17	induced	induce	VERB
bam-7218	917	18	muscle	muscle	NOUN
bam-7218	917	19	wasting	waste	VERB
bam-7218	917	20	sara	sara	PROPN
bam-7218	917	21	chiappalupi	chiappalupi	PROPN
bam-7218	917	22	*	*	PROPN
bam-7218	917	23	,	,	PUNCT
bam-7218	917	24	francesca	francesca	PROPN
bam-7218	917	25	riuzzi	riuzzi	PROPN
bam-7218	917	26	*	*	PROPN
bam-7218	917	27	,	,	PUNCT
bam-7218	917	28	laura	laura	PROPN
bam-7218	917	29	salvadori	salvadori	PROPN
bam-7218	917	30	,	,	PUNCT
bam-7218	917	31	roberta	roberta	PROPN
bam-7218	917	32	sagheddu	sagheddu	PROPN
bam-7218	917	33	,	,	PUNCT
bam-7218	917	34	rosario	rosario	PROPN
bam-7218	917	35	donato	donato	PROPN
bam-7218	917	36	,	,	PUNCT
bam-7218	917	37	guglielmo	guglielmo	PROPN
bam-7218	917	38	sorci	sorci	VERB
bam-7218	917	39	dept	dept	ADJ
bam-7218	917	40	experimental	experimental	ADJ
bam-7218	917	41	medicine	medicine	NOUN
bam-7218	917	42	,	,	PUNCT
bam-7218	917	43	university	university	PROPN
bam-7218	917	44	of	of	ADP
bam-7218	917	45	perugia	perugia	PROPN
bam-7218	917	46	,	,	PUNCT
bam-7218	917	47	perugia	perugia	PROPN
bam-7218	917	48	,	,	PUNCT
bam-7218	917	49	italy	italy	PROPN
bam-7218	917	50	.	.	PUNCT
bam-7218	918	1	e	e	X
bam-7218	918	2	-	-	NOUN
bam-7218	918	3	mail	mail	NOUN
bam-7218	918	4	:	:	PUNCT
bam-7218	918	5	sarac.84@libero.it	sarac.84@libero.it	NOUN
bam-7218	918	6	cancer	cancer	NOUN
bam-7218	918	7	is	be	AUX
bam-7218	918	8	a	a	DET
bam-7218	918	9	recognized	recognize	VERB
bam-7218	918	10	cause	cause	NOUN
bam-7218	918	11	of	of	ADP
bam-7218	918	12	the	the	DET
bam-7218	918	13	prominently	prominently	ADV
bam-7218	918	14	reduced	reduce	VERB
bam-7218	918	15	muscle	muscle	NOUN
bam-7218	918	16	mass	mass	NOUN
bam-7218	918	17	known	know	VERB
bam-7218	918	18	as	as	ADP
bam-7218	918	19	cachexia	cachexia	NOUN
bam-7218	918	20	.	.	PUNCT
bam-7218	919	1	inflammatory	inflammatory	ADJ
bam-7218	919	2	cytokines	cytokine	NOUN
bam-7218	919	3	such	such	ADJ
bam-7218	919	4	as	as	ADP
bam-7218	919	5	tnf	tnf	PROPN
bam-7218	919	6	-	-	PUNCT
bam-7218	919	7	α	α	PROPN
bam-7218	919	8	,	,	PUNCT
bam-7218	919	9	il-1β	il-1β	PROPN
bam-7218	919	10	,	,	PUNCT
bam-7218	919	11	il-6	il-6	NUM
bam-7218	919	12	and	and	CCONJ
bam-7218	919	13	ifn	ifn	PROPN
bam-7218	919	14	-	-	PUNCT
bam-7218	919	15	γ	γ	NOUN
bam-7218	919	16	are	be	AUX
bam-7218	919	17	main	main	ADJ
bam-7218	919	18	atrophy	atrophy	NOUN
bam-7218	919	19	-	-	PUNCT
bam-7218	919	20	inducing	induce	VERB
bam-7218	919	21	factors	factor	NOUN
bam-7218	919	22	in	in	ADP
bam-7218	919	23	cachexia	cachexia	NOUN
bam-7218	919	24	causing	cause	VERB
bam-7218	919	25	excess	excess	ADJ
bam-7218	919	26	catabolism	catabolism	NOUN
bam-7218	919	27	of	of	ADP
bam-7218	919	28	myofibrillary	myofibrillary	ADJ
bam-7218	919	29	proteins	protein	NOUN
bam-7218	919	30	.	.	PUNCT
bam-7218	920	1	1	1	NUM
bam-7218	920	2	rage	rage	NOUN
bam-7218	920	3	(	(	PUNCT
bam-7218	920	4	receptor	receptor	NOUN
bam-7218	920	5	for	for	ADP
bam-7218	920	6	advanced	advanced	ADJ
bam-7218	920	7	glycation	glycation	NOUN
bam-7218	920	8	end	end	NOUN
bam-7218	920	9	-	-	PUNCT
bam-7218	920	10	products	product	NOUN
bam-7218	920	11	)	)	PUNCT
bam-7218	920	12	and	and	CCONJ
bam-7218	920	13	its	its	PRON
bam-7218	920	14	physiological	physiological	ADJ
bam-7218	920	15	ligands	ligand	NOUN
bam-7218	920	16	,	,	PUNCT
bam-7218	920	17	s100b	s100b	PROPN
bam-7218	920	18	and	and	CCONJ
bam-7218	920	19	hmgb1	hmgb1	PROPN
bam-7218	920	20	,	,	PUNCT
bam-7218	920	21	are	be	AUX
bam-7218	920	22	involved	involve	VERB
bam-7218	920	23	in	in	ADP
bam-7218	920	24	muscle	muscle	NOUN
bam-7218	920	25	regeneration	regeneration	NOUN
bam-7218	920	26	,	,	PUNCT
bam-7218	920	27	inflammation	inflammation	NOUN
bam-7218	920	28	,	,	PUNCT
bam-7218	920	29	and	and	CCONJ
bam-7218	920	30	tumor	tumor	NOUN
bam-7218	920	31	growth	growth	NOUN
bam-7218	920	32	,	,	PUNCT
bam-7218	920	33	which	which	PRON
bam-7218	920	34	represent	represent	VERB
bam-7218	920	35	key	key	ADJ
bam-7218	920	36	processes	process	NOUN
bam-7218	920	37	in	in	ADP
bam-7218	920	38	cancer	cancer	NOUN
bam-7218	920	39	cachexia	cachexia	NOUN
bam-7218	920	40	.	.	PUNCT
bam-7218	921	1	2,3	2,3	NOUN
bam-7218	921	2	we	we	PRON
bam-7218	921	3	found	find	VERB
bam-7218	921	4	that	that	SCONJ
bam-7218	921	5	:	:	PUNCT
bam-7218	921	6	i	i	PRON
bam-7218	921	7	)	)	PUNCT
bam-7218	921	8	rage	rage	NOUN
bam-7218	921	9	signaling	signal	VERB
bam-7218	921	10	has	have	VERB
bam-7218	921	11	a	a	DET
bam-7218	921	12	trophic	trophic	ADJ
bam-7218	921	13	effect	effect	NOUN
bam-7218	921	14	in	in	ADP
bam-7218	921	15	myotubes	myotube	NOUN
bam-7218	921	16	in	in	ADP
bam-7218	921	17	physiological	physiological	ADJ
bam-7218	921	18	conditions	condition	NOUN
bam-7218	921	19	;	;	PUNCT
bam-7218	921	20	ii	ii	X
bam-7218	921	21	)	)	PUNCT
bam-7218	921	22	excess	excess	ADJ
bam-7218	921	23	rage	rage	NOUN
bam-7218	921	24	ligands	ligand	NOUN
bam-7218	921	25	leads	lead	VERB
bam-7218	921	26	to	to	PART
bam-7218	921	27	myotube	myotube	VERB
bam-7218	921	28	atrophy	atrophy	NOUN
bam-7218	921	29	;	;	PUNCT
bam-7218	921	30	iii	iii	X
bam-7218	921	31	)	)	PUNCT
bam-7218	921	32	high	high	ADJ
bam-7218	921	33	amounts	amount	NOUN
bam-7218	921	34	of	of	ADP
bam-7218	921	35	s100b	s100b	PROPN
bam-7218	921	36	and	and	CCONJ
bam-7218	921	37	hmgb1	hmgb1	PROPN
bam-7218	921	38	are	be	AUX
bam-7218	921	39	found	find	VERB
bam-7218	921	40	in	in	ADP
bam-7218	921	41	cachectic	cachectic	ADJ
bam-7218	921	42	muscles	muscle	NOUN
bam-7218	921	43	,	,	PUNCT
bam-7218	921	44	and	and	CCONJ
bam-7218	921	45	elevated	elevated	ADJ
bam-7218	921	46	levels	level	NOUN
bam-7218	921	47	of	of	ADP
bam-7218	921	48	s100b	s100b	PROPN
bam-7218	921	49	are	be	AUX
bam-7218	921	50	present	present	ADJ
bam-7218	921	51	in	in	ADP
bam-7218	921	52	the	the	DET
bam-7218	921	53	serum	serum	NOUN
bam-7218	921	54	of	of	ADP
bam-7218	921	55	cachectic	cachectic	ADJ
bam-7218	921	56	mice	mouse	NOUN
bam-7218	921	57	,	,	PUNCT
bam-7218	921	58	likely	likely	ADV
bam-7218	921	59	released	release	VERB
bam-7218	921	60	by	by	ADP
bam-7218	921	61	tumor	tumor	NOUN
bam-7218	921	62	cells	cell	NOUN
bam-7218	921	63	;	;	PUNCT
bam-7218	921	64	iv	iv	X
bam-7218	921	65	)	)	PUNCT
bam-7218	921	66	atrophying	atrophy	VERB
bam-7218	921	67	muscles	muscle	NOUN
bam-7218	921	68	re	re	ADJ
bam-7218	921	69	-	-	NOUN
bam-7218	921	70	express	express	ADJ
bam-7218	921	71	rage	rage	NOUN
bam-7218	921	72	;	;	PUNCT
bam-7218	921	73	v	v	X
bam-7218	921	74	)	)	PUNCT
bam-7218	921	75	rage	rage	NOUN
bam-7218	921	76	,	,	PUNCT
bam-7218	921	77	s100b	s100b	PROPN
bam-7218	921	78	and	and	CCONJ
bam-7218	921	79	hmgb1	hmgb1	PROPN
bam-7218	921	80	are	be	AUX
bam-7218	921	81	involved	involve	VERB
bam-7218	921	82	in	in	ADP
bam-7218	921	83	the	the	DET
bam-7218	921	84	mechanism	mechanism	NOUN
bam-7218	921	85	through	through	ADP
bam-7218	921	86	which	which	PRON
bam-7218	921	87	tnfα±ifnγ	tnfα±ifnγ	NOUN
bam-7218	921	88	induces	induce	VERB
bam-7218	921	89	atrophy	atrophy	NOUN
bam-7218	921	90	in	in	ADP
bam-7218	921	91	myotubes	myotube	NOUN
bam-7218	921	92	in	in	ADP
bam-7218	921	93	vitro	vitro	X
bam-7218	921	94	and	and	CCONJ
bam-7218	921	95	in	in	ADP
bam-7218	921	96	muscles	muscle	NOUN
bam-7218	921	97	in	in	ADP
bam-7218	921	98	vivo	vivo	NOUN
bam-7218	921	99	;	;	PUNCT
bam-7218	921	100	vi	vi	X
bam-7218	921	101	)	)	PUNCT
bam-7218	921	102	lewis	lewis	PROPN
bam-7218	921	103	lung	lung	PROPN
bam-7218	921	104	carcinoma	carcinoma	NOUN
bam-7218	921	105	(	(	PUNCT
bam-7218	921	106	llc)-bearing	llc)-beare	VERB
bam-7218	921	107	rage	rage	NOUN
bam-7218	921	108	-	-	PUNCT
bam-7218	921	109	null	null	NOUN
bam-7218	921	110	(	(	PUNCT
bam-7218	921	111	ager	ager	PROPN
bam-7218	921	112	‒/‒	‒/‒	PROPN
bam-7218	921	113	)	)	PUNCT
bam-7218	921	114	mice	mouse	NOUN
bam-7218	921	115	show	show	VERB
bam-7218	921	116	reduced	reduce	VERB
bam-7218	921	117	loss	loss	NOUN
bam-7218	921	118	of	of	ADP
bam-7218	921	119	muscle	muscle	NOUN
bam-7218	921	120	mass	mass	NOUN
bam-7218	921	121	and	and	CCONJ
bam-7218	921	122	reduced	reduce	VERB
bam-7218	921	123	atrogenes	atrogene	NOUN
bam-7218	921	124	expression	expression	NOUN
bam-7218	921	125	,	,	PUNCT
bam-7218	921	126	and	and	CCONJ
bam-7218	921	127	a	a	DET
bam-7218	921	128	dramatic	dramatic	ADJ
bam-7218	921	129	increase	increase	NOUN
bam-7218	921	130	in	in	ADP
bam-7218	921	131	survival	survival	NOUN
bam-7218	921	132	rate	rate	NOUN
bam-7218	921	133	compared	compare	VERB
bam-7218	921	134	with	with	ADP
bam-7218	921	135	llc	llc	NOUN
bam-7218	921	136	-	-	PUNCT
bam-7218	921	137	bearing	bear	VERB
bam-7218	921	138	wt	wt	NOUN
bam-7218	921	139	mice	mouse	NOUN
bam-7218	921	140	,	,	PUNCT
bam-7218	921	141	likely	likely	ADJ
bam-7218	921	142	due	due	ADP
bam-7218	921	143	to	to	ADP
bam-7218	921	144	reduced	reduce	VERB
bam-7218	921	145	systemic	systemic	ADJ
bam-7218	921	146	inflammation	inflammation	NOUN
bam-7218	921	147	,	,	PUNCT
bam-7218	921	148	maintenance	maintenance	NOUN
bam-7218	921	149	of	of	ADP
bam-7218	921	150	spleen	spleen	NOUN
bam-7218	921	151	morphology	morphology	NOUN
bam-7218	921	152	and	and	CCONJ
bam-7218	921	153	a	a	DET
bam-7218	921	154	different	different	ADJ
bam-7218	921	155	tumor	tumor	NOUN
bam-7218	921	156	-	-	PUNCT
bam-7218	921	157	derived	derive	VERB
bam-7218	921	158	cytokine	cytokine	NOUN
bam-7218	921	159	profile	profile	NOUN
bam-7218	921	160	.	.	PUNCT
bam-7218	922	1	thus	thus	ADV
bam-7218	922	2	,	,	PUNCT
bam-7218	922	3	increased	increase	VERB
bam-7218	922	4	expression	expression	NOUN
bam-7218	922	5	/	/	SYM
bam-7218	922	6	activity	activity	NOUN
bam-7218	922	7	of	of	ADP
bam-7218	922	8	rage	rage	NOUN
bam-7218	922	9	and	and	CCONJ
bam-7218	922	10	its	its	PRON
bam-7218	922	11	ligands	ligand	NOUN
bam-7218	922	12	,	,	PUNCT
bam-7218	922	13	s100b	s100b	PROPN
bam-7218	922	14	and	and	CCONJ
bam-7218	922	15	hmgb1	hmgb1	PROPN
bam-7218	922	16	at	at	ADP
bam-7218	922	17	both	both	CCONJ
bam-7218	922	18	systemic	systemic	ADJ
bam-7218	922	19	and	and	CCONJ
bam-7218	922	20	muscle	muscle	NOUN
bam-7218	922	21	levels	level	NOUN
bam-7218	922	22	appears	appear	VERB
bam-7218	922	23	to	to	PART
bam-7218	922	24	concur	concur	VERB
bam-7218	922	25	to	to	ADP
bam-7218	922	26	muscle	muscle	NOUN
bam-7218	922	27	wasting	waste	VERB
bam-7218	922	28	in	in	ADP
bam-7218	922	29	cancer	cancer	NOUN
bam-7218	922	30	conditions	condition	NOUN
bam-7218	922	31	.	.	PUNCT
bam-7218	923	1	references	reference	NOUN
bam-7218	923	2	:	:	PUNCT
bam-7218	923	3	1	1	X
bam-7218	923	4	.	.	X
bam-7218	923	5	porporato	porporato	PROPN
bam-7218	923	6	p.e	p.e	PROPN
bam-7218	923	7	.	.	PROPN
bam-7218	923	8	,	,	PUNCT
bam-7218	923	9	2016	2016	NUM
bam-7218	923	10	,	,	PUNCT
bam-7218	923	11	oncogenesis	oncogenesis	NOUN
bam-7218	923	12	.	.	PUNCT
bam-7218	924	1	22(5	22(5	NOUN
bam-7218	924	2	):	):	PUNCT
bam-7218	924	3	e200	e200	PROPN
bam-7218	924	4	;	;	PUNCT
bam-7218	924	5	2	2	NUM
bam-7218	924	6	.	.	X
bam-7218	924	7	riuzzi	riuzzi	NOUN
bam-7218	924	8	f.	f.	PROPN
bam-7218	924	9	et	et	PROPN
bam-7218	925	1	al	al	PROPN
bam-7218	925	2	.	.	PROPN
bam-7218	925	3	,	,	PUNCT
bam-7218	925	4	2012	2012	NUM
bam-7218	925	5	,	,	PUNCT
bam-7218	925	6	j.	j.	PROPN
bam-7218	925	7	cell	cell	PROPN
bam-7218	925	8	sci	sci	PROPN
bam-7218	925	9	.	.	PUNCT
bam-7218	926	1	125:1440	125:1440	NUM
bam-7218	926	2	-	-	SYM
bam-7218	926	3	54	54	NUM
bam-7218	926	4	;	;	PUNCT
bam-7218	926	5	3	3	X
bam-7218	926	6	.	.	X
bam-7218	926	7	riuzzi	riuzzi	PROPN
bam-7218	926	8	f.	f.	PROPN
bam-7218	926	9	et	et	PROPN
bam-7218	927	1	al	al	PROPN
bam-7218	927	2	.	.	PROPN
bam-7218	927	3	,	,	PUNCT
bam-7218	927	4	2012	2012	NUM
bam-7218	927	5	,	,	PUNCT
bam-7218	927	6	plos	plos	PROPN
bam-7218	927	7	one	one	NUM
bam-7218	927	8	7(1	7(1	NUM
bam-7218	927	9	):	):	PUNCT
bam-7218	927	10	e28700	e28700	X
bam-7218	927	11	.	.	PUNCT
bam-7218	928	1	*	*	PUNCT
bam-7218	928	2	equally	equally	ADV
bam-7218	928	3	contributing	contribute	VERB
bam-7218	928	4	authors	author	NOUN
bam-7218	928	5	.	.	PUNCT
bam-7218	929	1	mailto:paola.ceccaroli@uniurb.it	mailto:paola.ceccaroli@uniurb.it	NOUN
bam-7218	929	2	mailto:sarac.84@libero.it	mailto:sarac.84@libero.it	PRON
bam-7218	929	3	14	14	NUM
bam-7218	929	4	th	th	NUM
bam-7218	929	5	iiim	iiim	NOUN
bam-7218	929	6	meeting	meeting	NOUN
bam-7218	929	7	,	,	PUNCT
bam-7218	929	8	assisi	assisi	PROPN
bam-7218	929	9	,	,	PUNCT
bam-7218	929	10	italy	italy	PROPN
bam-7218	929	11	october	october	PROPN
bam-7218	929	12	12	12	NUM
bam-7218	929	13	-	-	SYM
bam-7218	929	14	15	15	NUM
bam-7218	929	15	2017	2017	NUM
bam-7218	929	16	eur	eur	PROPN
bam-7218	929	17	j	j	PROPN
bam-7218	929	18	transl	transl	PROPN
bam-7218	929	19	myol	myol	ADV
bam-7218	929	20	27	27	NUM
bam-7218	929	21	(	(	PUNCT
bam-7218	929	22	4	4	NUM
bam-7218	929	23	):	):	SYM
bam-7218	929	24	185	185	NUM
bam-7218	929	25	-	-	SYM
bam-7218	929	26	224	224	NUM
bam-7218	929	27	213	213	NUM
bam-7218	929	28	p.12	p.12	NOUN
bam-7218	929	29	effect	effect	NOUN
bam-7218	929	30	of	of	ADP
bam-7218	929	31	flywheel	flywheel	NOUN
bam-7218	929	32	-	-	PUNCT
bam-7218	929	33	based	base	VERB
bam-7218	929	34	isoinertial	isoinertial	ADJ
bam-7218	929	35	exercise	exercise	NOUN
bam-7218	929	36	on	on	ADP
bam-7218	929	37	markers	marker	NOUN
bam-7218	929	38	of	of	ADP
bam-7218	929	39	skeletal	skeletal	ADJ
bam-7218	929	40	muscle	muscle	NOUN
bam-7218	929	41	adaptations	adaptation	NOUN
bam-7218	929	42	serena	serena	PROPN
bam-7218	929	43	contarelli	contarelli	PROPN
bam-7218	929	44	(	(	PUNCT
bam-7218	929	45	a	a	X
bam-7218	929	46	)	)	PUNCT
bam-7218	929	47	,	,	PUNCT
bam-7218	929	48	giosuè	giosuè	NOUN
bam-7218	929	49	annibalini	annibalini	PROPN
bam-7218	929	50	(	(	PUNCT
bam-7218	929	51	a	a	NOUN
bam-7218	929	52	)	)	PUNCT
bam-7218	929	53	,	,	PUNCT
bam-7218	929	54	michele	michele	PROPN
bam-7218	929	55	guescini	guescini	PROPN
bam-7218	929	56	(	(	PUNCT
bam-7218	929	57	a	a	NOUN
bam-7218	929	58	)	)	PUNCT
bam-7218	929	59	,	,	PUNCT
bam-7218	929	60	serena	serena	PROPN
bam-7218	929	61	maggio	maggio	PROPN
bam-7218	929	62	(	(	PUNCT
bam-7218	929	63	a	a	X
bam-7218	929	64	)	)	PUNCT
bam-7218	929	65	,	,	PUNCT
bam-7218	929	66	paola	paola	PROPN
bam-7218	929	67	ceccaroli	ceccaroli	PROPN
bam-7218	929	68	(	(	PUNCT
bam-7218	929	69	a	a	NOUN
bam-7218	929	70	)	)	PUNCT
bam-7218	929	71	,	,	PUNCT
bam-7218	929	72	francesco	francesco	PROPN
bam-7218	929	73	lucertini	lucertini	PROPN
bam-7218	929	74	(	(	PUNCT
bam-7218	929	75	a	a	NOUN
bam-7218	929	76	)	)	PUNCT
bam-7218	929	77	,	,	PUNCT
bam-7218	929	78	marco	marco	PROPN
bam-7218	929	79	gervasi	gervasi	PROPN
bam-7218	929	80	(	(	PUNCT
bam-7218	929	81	a	a	NOUN
bam-7218	929	82	)	)	PUNCT
bam-7218	929	83	,	,	PUNCT
bam-7218	929	84	carlo	carlo	PROPN
bam-7218	929	85	ferri	ferri	PROPN
bam-7218	929	86	marini	marini	PROPN
bam-7218	929	87	(	(	PUNCT
bam-7218	929	88	a	a	NOUN
bam-7218	929	89	)	)	PUNCT
bam-7218	929	90	,	,	PUNCT
bam-7218	929	91	francesco	francesco	PROPN
bam-7218	929	92	fardetti	fardetti	PROPN
bam-7218	929	93	(	(	PUNCT
bam-7218	929	94	a	a	NOUN
bam-7218	929	95	)	)	PUNCT
bam-7218	929	96	,	,	PUNCT
bam-7218	929	97	eugenio	eugenio	PROPN
bam-7218	929	98	grassi	grassi	PROPN
bam-7218	929	99	(	(	PUNCT
bam-7218	929	100	a	a	PROPN
bam-7218	929	101	)	)	PUNCT
bam-7218	929	102	,	,	PUNCT
bam-7218	929	103	piero	piero	PROPN
bam-7218	929	104	benelli	benelli	PROPN
bam-7218	929	105	(	(	PUNCT
bam-7218	929	106	a	a	NOUN
bam-7218	929	107	)	)	PUNCT
bam-7218	929	108	,	,	PUNCT
bam-7218	929	109	vilberto	vilberto	PROPN
bam-7218	929	110	stocchi	stocchi	PROPN
bam-7218	929	111	(	(	PUNCT
bam-7218	929	112	a	a	X
bam-7218	929	113	)	)	PUNCT
bam-7218	929	114	,	,	PUNCT
bam-7218	929	115	elena	elena	PROPN
bam-7218	929	116	barbieri	barbieri	PROPN
bam-7218	929	117	(	(	PUNCT
bam-7218	929	118	a	a	DET
bam-7218	929	119	,	,	PUNCT
bam-7218	929	120	b	b	NOUN
bam-7218	929	121	)	)	PUNCT
bam-7218	929	122	(	(	PUNCT
bam-7218	929	123	a	a	X
bam-7218	929	124	)	)	PUNCT
bam-7218	929	125	dept	dept	NOUN
bam-7218	929	126	of	of	ADP
bam-7218	929	127	biomolecular	biomolecular	ADJ
bam-7218	929	128	sciences	science	NOUN
bam-7218	929	129	division	division	NOUN
bam-7218	929	130	of	of	ADP
bam-7218	929	131	exercise	exercise	NOUN
bam-7218	929	132	and	and	CCONJ
bam-7218	929	133	health	health	NOUN
bam-7218	929	134	sciences	sciences	PROPN
bam-7218	929	135	,	,	PUNCT
bam-7218	929	136	university	university	NOUN
bam-7218	929	137	of	of	ADP
bam-7218	929	138	urbino	urbino	PROPN
bam-7218	929	139	carlo	carlo	PROPN
bam-7218	929	140	bo	bo	PROPN
bam-7218	929	141	,	,	PUNCT
bam-7218	929	142	urbino	urbino	PROPN
bam-7218	929	143	,	,	PUNCT
bam-7218	929	144	italy	italy	PROPN
bam-7218	929	145	;	;	PUNCT
bam-7218	929	146	(	(	PUNCT
bam-7218	929	147	b)interuniversity	b)interuniversity	PROPN
bam-7218	929	148	institute	institute	NOUN
bam-7218	929	149	of	of	ADP
bam-7218	929	150	myology	myology	NOUN
bam-7218	929	151	,	,	PUNCT
bam-7218	929	152	urbino	urbino	PROPN
bam-7218	929	153	,	,	PUNCT
bam-7218	929	154	italy	italy	PROPN
bam-7218	929	155	.	.	PUNCT
bam-7218	930	1	e	e	X
bam-7218	930	2	-	-	NOUN
bam-7218	930	3	mail	mail	NOUN
bam-7218	930	4	:	:	PUNCT
bam-7218	930	5	serena.contarelli@uniurb.it	serena.contarelli@uniurb.it	NOUN
bam-7218	930	6	flywheel	flywheel	NOUN
bam-7218	930	7	-	-	PUNCT
bam-7218	930	8	based	base	VERB
bam-7218	930	9	isoinertial	isoinertial	ADJ
bam-7218	930	10	exercise	exercise	NOUN
bam-7218	930	11	was	be	AUX
bam-7218	930	12	originally	originally	ADV
bam-7218	930	13	designed	design	VERB
bam-7218	930	14	to	to	PART
bam-7218	930	15	maintain	maintain	VERB
bam-7218	930	16	muscle	muscle	NOUN
bam-7218	930	17	health	health	NOUN
bam-7218	930	18	of	of	ADP
bam-7218	930	19	astronauts	astronaut	NOUN
bam-7218	930	20	during	during	ADP
bam-7218	930	21	spaceflight	spaceflight	PROPN
bam-7218	930	22	.	.	PUNCT
bam-7218	931	1	it	it	PRON
bam-7218	931	2	employs	employ	VERB
bam-7218	931	3	isoinertial	isoinertial	ADJ
bam-7218	931	4	technology	technology	NOUN
bam-7218	931	5	rather	rather	ADV
bam-7218	931	6	than	than	ADP
bam-7218	931	7	gravity	gravity	NOUN
bam-7218	931	8	dependent	dependent	ADJ
bam-7218	931	9	weights	weight	NOUN
bam-7218	931	10	,	,	PUNCT
bam-7218	931	11	which	which	PRON
bam-7218	931	12	allows	allow	VERB
bam-7218	931	13	for	for	ADP
bam-7218	931	14	maximal	maximal	ADJ
bam-7218	931	15	concentric	concentric	ADJ
bam-7218	931	16	and	and	CCONJ
bam-7218	931	17	eccentric	eccentric	ADJ
bam-7218	931	18	muscle	muscle	NOUN
bam-7218	931	19	actions	action	NOUN
bam-7218	931	20	,	,	PUNCT
bam-7218	931	21	with	with	ADP
bam-7218	931	22	brief	brief	ADJ
bam-7218	931	23	episodes	episode	NOUN
bam-7218	931	24	of	of	ADP
bam-7218	931	25	eccentric	eccentric	ADJ
bam-7218	931	26	overload	overload	NOUN
bam-7218	931	27	.	.	PUNCT
bam-7218	932	1	isoinertial	isoinertial	ADJ
bam-7218	932	2	exercise	exercise	NOUN
bam-7218	932	3	produces	produce	VERB
bam-7218	932	4	greater	great	ADJ
bam-7218	932	5	muscle	muscle	NOUN
bam-7218	932	6	hypertrophy	hypertrophy	NOUN
bam-7218	932	7	and	and	CCONJ
bam-7218	932	8	peripheral	peripheral	ADJ
bam-7218	932	9	neural	neural	ADJ
bam-7218	932	10	adaptations	adaptation	NOUN
bam-7218	932	11	than	than	ADP
bam-7218	932	12	weight	weight	NOUN
bam-7218	932	13	-	-	PUNCT
bam-7218	932	14	loaded	load	VERB
bam-7218	932	15	resistance	resistance	NOUN
bam-7218	932	16	exercise	exercise	NOUN
bam-7218	932	17	in	in	ADP
bam-7218	932	18	healthy	healthy	ADJ
bam-7218	932	19	subjects	subject	NOUN
bam-7218	932	20	probably	probably	ADV
bam-7218	932	21	due	due	ADJ
bam-7218	932	22	to	to	ADP
bam-7218	932	23	the	the	DET
bam-7218	932	24	eccentric	eccentric	ADJ
bam-7218	932	25	overload	overload	NOUN
bam-7218	932	26	.	.	PUNCT
bam-7218	933	1	the	the	DET
bam-7218	933	2	purpose	purpose	NOUN
bam-7218	933	3	of	of	ADP
bam-7218	933	4	this	this	DET
bam-7218	933	5	study	study	NOUN
bam-7218	933	6	was	be	AUX
bam-7218	933	7	to	to	PART
bam-7218	933	8	analyse	analyse	VERB
bam-7218	933	9	the	the	DET
bam-7218	933	10	modulation	modulation	NOUN
bam-7218	933	11	of	of	ADP
bam-7218	933	12	circulating	circulate	VERB
bam-7218	933	13	and	and	CCONJ
bam-7218	933	14	local	local	ADJ
bam-7218	933	15	molecular	molecular	ADJ
bam-7218	933	16	markers	marker	NOUN
bam-7218	933	17	of	of	ADP
bam-7218	933	18	muscle	muscle	NOUN
bam-7218	933	19	damage	damage	NOUN
bam-7218	933	20	and	and	CCONJ
bam-7218	933	21	growth	growth	NOUN
bam-7218	933	22	/	/	SYM
bam-7218	933	23	repair	repair	NOUN
bam-7218	933	24	over	over	ADP
bam-7218	933	25	48h	48h	NOUN
bam-7218	933	26	after	after	ADP
bam-7218	933	27	an	an	DET
bam-7218	933	28	isoinertial	isoinertial	ADJ
bam-7218	933	29	exercise	exercise	NOUN
bam-7218	933	30	.	.	PUNCT
bam-7218	934	1	eight	eight	NUM
bam-7218	934	2	male	male	ADJ
bam-7218	934	3	collegiate	collegiate	ADJ
bam-7218	934	4	students	student	NOUN
bam-7218	934	5	(	(	PUNCT
bam-7218	934	6	with	with	ADP
bam-7218	934	7	at	at	ADV
bam-7218	934	8	least	least	ADV
bam-7218	934	9	2	2	NUM
bam-7218	934	10	years	year	NOUN
bam-7218	934	11	of	of	ADP
bam-7218	934	12	squatting	squatting	NOUN
bam-7218	934	13	experience	experience	NOUN
bam-7218	934	14	)	)	PUNCT
bam-7218	934	15	performed	perform	VERB
bam-7218	934	16	a	a	DET
bam-7218	934	17	session	session	NOUN
bam-7218	934	18	of	of	ADP
bam-7218	934	19	isoinertial	isoinertial	ADJ
bam-7218	934	20	squat	squat	ADJ
bam-7218	934	21	exercise	exercise	NOUN
bam-7218	934	22	(	(	PUNCT
bam-7218	934	23	5	5	NUM
bam-7218	934	24	sets	set	NOUN
bam-7218	934	25	of	of	ADP
bam-7218	934	26	10	10	NUM
bam-7218	934	27	maximal	maximal	ADJ
bam-7218	934	28	reps	rep	NOUN
bam-7218	934	29	;	;	PUNCT
bam-7218	934	30	3	3	NUM
bam-7218	934	31	’	'	PUNCT
bam-7218	934	32	rest	rest	NOUN
bam-7218	934	33	in	in	ADP
bam-7218	934	34	-	-	PUNCT
bam-7218	934	35	between	between	NOUN
bam-7218	934	36	)	)	PUNCT
bam-7218	934	37	on	on	ADP
bam-7218	934	38	the	the	DET
bam-7218	934	39	d11	d11	PROPN
bam-7218	934	40	flywheel	flywheel	NOUN
bam-7218	934	41	device	device	NOUN
bam-7218	934	42	(	(	PUNCT
bam-7218	934	43	desmotec	desmotec	NOUN
bam-7218	934	44	,	,	PUNCT
bam-7218	934	45	italy	italy	PROPN
bam-7218	934	46	)	)	PUNCT
bam-7218	934	47	.	.	PUNCT
bam-7218	935	1	circulating	circulate	VERB
bam-7218	935	2	markers	marker	NOUN
bam-7218	935	3	analyzed	analyze	VERB
bam-7218	935	4	were	be	AUX
bam-7218	935	5	:	:	PUNCT
bam-7218	935	6	muscle	muscle	NOUN
bam-7218	935	7	creatine	creatine	PROPN
bam-7218	935	8	kinase	kinase	PROPN
bam-7218	935	9	(	(	PUNCT
bam-7218	935	10	ckm	ckm	PROPN
bam-7218	935	11	)	)	PUNCT
bam-7218	935	12	,	,	PUNCT
bam-7218	935	13	insulin	insulin	NOUN
bam-7218	935	14	-	-	PUNCT
bam-7218	935	15	like	like	ADJ
bam-7218	935	16	growths	growth	NOUN
bam-7218	935	17	factor-1	factor-1	PROPN
bam-7218	935	18	(	(	PUNCT
bam-7218	935	19	igf-1	igf-1	NOUN
bam-7218	935	20	)	)	PUNCT
bam-7218	935	21	and	and	CCONJ
bam-7218	935	22	interleukin-6	interleukin-6	NUM
bam-7218	935	23	(	(	PUNCT
bam-7218	935	24	il-6	il-6	NUM
bam-7218	935	25	)	)	PUNCT
bam-7218	935	26	;	;	PUNCT
bam-7218	935	27	measured	measure	VERB
bam-7218	935	28	before	before	ADV
bam-7218	935	29	and	and	CCONJ
bam-7218	935	30	2	2	NUM
bam-7218	935	31	,	,	PUNCT
bam-7218	935	32	24	24	NUM
bam-7218	935	33	,	,	PUNCT
bam-7218	935	34	48h	48h	NOUN
bam-7218	935	35	post	post	NOUN
bam-7218	935	36	-	-	NOUN
bam-7218	935	37	exercise	exercise	NOUN
bam-7218	935	38	.	.	PUNCT
bam-7218	936	1	in	in	ADP
bam-7218	936	2	addition	addition	NOUN
bam-7218	936	3	,	,	PUNCT
bam-7218	936	4	mirnas	mirna	NOUN
bam-7218	936	5	(	(	PUNCT
bam-7218	936	6	mir-1	mir-1	NUM
bam-7218	936	7	,	,	PUNCT
bam-7218	936	8	-133b	-133b	VERB
bam-7218	936	9	,	,	PUNCT
bam-7218	936	10	206	206	NUM
bam-7218	936	11	,	,	PUNCT
bam-7218	936	12	-146a	-146a	ADJ
bam-7218	936	13	,	,	PUNCT
bam-7218	936	14	-126	-126	PROPN
bam-7218	936	15	and	and	CCONJ
bam-7218	936	16	-423	-423	PROPN
bam-7218	936	17	)	)	PUNCT
bam-7218	936	18	encapsulated	encapsulate	VERB
bam-7218	936	19	in	in	ADP
bam-7218	936	20	circulating	circulate	VERB
bam-7218	936	21	exosomes	exosome	NOUN
bam-7218	936	22	were	be	AUX
bam-7218	936	23	quantified	quantify	VERB
bam-7218	936	24	before	before	ADP
bam-7218	936	25	and	and	CCONJ
bam-7218	936	26	2h	2h	NUM
bam-7218	936	27	after	after	ADP
bam-7218	936	28	exercise	exercise	NOUN
bam-7218	936	29	.	.	PUNCT
bam-7218	937	1	local	local	ADJ
bam-7218	937	2	markers	marker	NOUN
bam-7218	937	3	investigated	investigate	VERB
bam-7218	937	4	were	be	AUX
bam-7218	937	5	:	:	PUNCT
bam-7218	937	6	mrna	mrna	PROPN
bam-7218	937	7	levels	level	NOUN
bam-7218	937	8	of	of	ADP
bam-7218	937	9	genes	gene	NOUN
bam-7218	937	10	involved	involve	VERB
bam-7218	937	11	in	in	ADP
bam-7218	937	12	myogenesis	myogenesis	NOUN
bam-7218	937	13	and	and	CCONJ
bam-7218	937	14	cell	cell	NOUN
bam-7218	937	15	cycle	cycle	NOUN
bam-7218	937	16	control	control	NOUN
bam-7218	937	17	such	such	ADJ
bam-7218	937	18	as	as	ADP
bam-7218	937	19	igf-1	igf-1	NOUN
bam-7218	937	20	isoforms	isoform	NOUN
bam-7218	937	21	(	(	PUNCT
bam-7218	937	22	igf-1ea	igf-1ea	NUM
bam-7218	937	23	,	,	PUNCT
bam-7218	937	24	igf-1eb	igf-1eb	PROPN
bam-7218	937	25	,	,	PUNCT
bam-7218	937	26	and	and	CCONJ
bam-7218	937	27	igf-1ec	igf-1ec	NUM
bam-7218	937	28	)	)	PUNCT
bam-7218	937	29	,	,	PUNCT
bam-7218	937	30	myogenin	myogenin	ADJ
bam-7218	937	31	,	,	PUNCT
bam-7218	937	32	myogenic	myogenic	ADJ
bam-7218	937	33	regulator	regulator	NOUN
bam-7218	937	34	factor-4	factor-4	NUM
bam-7218	937	35	(	(	PUNCT
bam-7218	937	36	mrf-4	mrf-4	ADJ
bam-7218	937	37	)	)	PUNCT
bam-7218	937	38	and	and	CCONJ
bam-7218	937	39	cyclin	cyclin	NOUN
bam-7218	937	40	d1	d1	PROPN
bam-7218	937	41	;	;	PUNCT
bam-7218	937	42	determined	determine	VERB
bam-7218	937	43	in	in	ADP
bam-7218	937	44	vastus	vastus	NOUN
bam-7218	937	45	lateralis	lateralis	NOUN
bam-7218	937	46	muscle	muscle	NOUN
bam-7218	937	47	using	use	VERB
bam-7218	937	48	fine	fine	ADJ
bam-7218	937	49	needle	needle	NOUN
bam-7218	937	50	aspiration	aspiration	NOUN
bam-7218	937	51	coupled	couple	VERB
bam-7218	937	52	with	with	ADP
bam-7218	937	53	real	real	ADJ
bam-7218	937	54	-	-	PUNCT
bam-7218	937	55	time	time	NOUN
bam-7218	937	56	pcr	pcr	NOUN
bam-7218	937	57	before	before	ADP
bam-7218	937	58	and	and	CCONJ
bam-7218	937	59	2h	2h	NUM
bam-7218	937	60	post	post	NOUN
bam-7218	937	61	-	-	NOUN
bam-7218	937	62	exercise	exercise	NOUN
bam-7218	937	63	.	.	PUNCT
bam-7218	938	1	exercise	exercise	NOUN
bam-7218	938	2	-	-	PUNCT
bam-7218	938	3	induced	induce	VERB
bam-7218	938	4	inflammatory	inflammatory	ADJ
bam-7218	938	5	response	response	NOUN
bam-7218	938	6	was	be	AUX
bam-7218	938	7	also	also	ADV
bam-7218	938	8	analyzed	analyze	VERB
bam-7218	938	9	by	by	ADP
bam-7218	938	10	quantification	quantification	NOUN
bam-7218	938	11	of	of	ADP
bam-7218	938	12	mrna	mrna	PROPN
bam-7218	938	13	encoding	encode	VERB
bam-7218	938	14	cytokines	cytokine	NOUN
bam-7218	938	15	and	and	CCONJ
bam-7218	938	16	chemokines	chemokine	NOUN
bam-7218	938	17	(	(	PUNCT
bam-7218	938	18	iκb	iκb	NOUN
bam-7218	938	19	-	-	PUNCT
bam-7218	938	20	α	α	NOUN
bam-7218	938	21	,	,	PUNCT
bam-7218	938	22	mcp-1	mcp-1	NOUN
bam-7218	938	23	,	,	PUNCT
bam-7218	938	24	tnfα	tnfα	NOUN
bam-7218	938	25	,	,	PUNCT
bam-7218	938	26	il-6	il-6	NOUN
bam-7218	938	27	and	and	CCONJ
bam-7218	938	28	il-6r	il-6r	NOUN
bam-7218	938	29	)	)	PUNCT
bam-7218	938	30	in	in	ADP
bam-7218	938	31	muscle	muscle	NOUN
bam-7218	938	32	and	and	CCONJ
bam-7218	938	33	in	in	ADP
bam-7218	938	34	peripheral	peripheral	ADJ
bam-7218	938	35	blood	blood	NOUN
bam-7218	938	36	mononuclear	mononuclear	ADJ
bam-7218	938	37	cells	cell	NOUN
bam-7218	938	38	(	(	PUNCT
bam-7218	938	39	pbmc	pbmc	NOUN
bam-7218	938	40	)	)	PUNCT
bam-7218	938	41	.	.	PUNCT
bam-7218	939	1	circulating	circulate	VERB
bam-7218	939	2	ckm	ckm	PROPN
bam-7218	939	3	increased	increase	VERB
bam-7218	939	4	significantly	significantly	ADV
bam-7218	939	5	after	after	ADP
bam-7218	939	6	2h	2h	NUM
bam-7218	939	7	post	post	ADJ
bam-7218	939	8	-	-	ADJ
bam-7218	939	9	exercise	exercise	ADJ
bam-7218	939	10	,	,	PUNCT
bam-7218	939	11	the	the	DET
bam-7218	939	12	maximum	maximum	ADJ
bam-7218	939	13	peak	peak	NOUN
bam-7218	939	14	occurred	occur	VERB
bam-7218	939	15	within	within	ADP
bam-7218	939	16	24h	24h	NOUN
bam-7218	939	17	restoring	restore	VERB
bam-7218	939	18	to	to	PART
bam-7218	939	19	baseline	baseline	VERB
bam-7218	939	20	level	level	NOUN
bam-7218	939	21	within	within	ADP
bam-7218	939	22	48h	48h	NOUN
bam-7218	939	23	.	.	PUNCT
bam-7218	940	1	isoinertial	isoinertial	ADJ
bam-7218	940	2	exercise	exercise	NOUN
bam-7218	940	3	significantly	significantly	ADV
bam-7218	940	4	increased	increase	VERB
bam-7218	940	5	total	total	ADJ
bam-7218	940	6	serum	serum	NOUN
bam-7218	940	7	igf-1	igf-1	ADV
bam-7218	940	8	24h	24h	VERB
bam-7218	940	9	post	post	ADJ
bam-7218	940	10	-	-	ADJ
bam-7218	940	11	exercise	exercise	NOUN
bam-7218	940	12	and	and	CCONJ
bam-7218	940	13	il-6	il-6	NOUN
bam-7218	940	14	at	at	ADP
bam-7218	940	15	2	2	NUM
bam-7218	940	16	,	,	PUNCT
bam-7218	940	17	24	24	NUM
bam-7218	940	18	and	and	CCONJ
bam-7218	940	19	48h	48h	NOUN
bam-7218	940	20	post	post	ADJ
bam-7218	940	21	-	-	ADJ
bam-7218	940	22	exercise	exercise	ADJ
bam-7218	940	23	.	.	PUNCT
bam-7218	941	1	nanoparticle	nanoparticle	NOUN
bam-7218	941	2	tracking	tracking	NOUN
bam-7218	941	3	assay	assay	PROPN
bam-7218	941	4	revealed	reveal	VERB
bam-7218	941	5	a	a	DET
bam-7218	941	6	2	2	NUM
bam-7218	941	7	-	-	ADJ
bam-7218	941	8	fold	fold	ADJ
bam-7218	941	9	increase	increase	NOUN
bam-7218	941	10	in	in	ADP
bam-7218	941	11	circulating	circulate	VERB
bam-7218	941	12	exosomes	exosome	NOUN
bam-7218	941	13	in	in	ADP
bam-7218	941	14	response	response	NOUN
bam-7218	941	15	to	to	ADP
bam-7218	941	16	acute	acute	ADJ
bam-7218	941	17	exercise	exercise	NOUN
bam-7218	941	18	,	,	PUNCT
bam-7218	941	19	which	which	PRON
bam-7218	941	20	was	be	AUX
bam-7218	941	21	paralleled	parallel	VERB
bam-7218	941	22	by	by	ADP
bam-7218	941	23	higher	high	ADJ
bam-7218	941	24	levels	level	NOUN
bam-7218	941	25	of	of	ADP
bam-7218	941	26	the	the	DET
bam-7218	941	27	mir-146a	mir-146a	ADJ
bam-7218	941	28	ad	ad	NOUN
bam-7218	941	29	mir-126	mir-126	NOUN
bam-7218	941	30	.	.	PUNCT
bam-7218	942	1	exercise	exercise	NOUN
bam-7218	942	2	increased	increase	VERB
bam-7218	942	3	muscle	muscle	NOUN
bam-7218	942	4	mcp-1	mcp-1	NOUN
bam-7218	942	5	,	,	PUNCT
bam-7218	942	6	tnf	tnf	PROPN
bam-7218	942	7	-	-	PUNCT
bam-7218	942	8	α	α	PROPN
bam-7218	942	9	and	and	CCONJ
bam-7218	942	10	il-6	il-6	NOUN
bam-7218	942	11	and	and	CCONJ
bam-7218	942	12	peripheral	peripheral	ADJ
bam-7218	942	13	pbmc	pbmc	NOUN
bam-7218	942	14	ikb	ikb	PROPN
bam-7218	942	15	-	-	PUNCT
bam-7218	942	16	α	α	NOUN
bam-7218	942	17	and	and	CCONJ
bam-7218	942	18	mcp-1	mcp-1	NOUN
bam-7218	942	19	mrna	mrna	PROPN
bam-7218	942	20	levels	level	NOUN
bam-7218	942	21	2h	2h	NUM
bam-7218	942	22	post	post	NOUN
bam-7218	942	23	-	-	NOUN
bam-7218	942	24	exercise	exercise	NOUN
bam-7218	942	25	.	.	PUNCT
bam-7218	943	1	on	on	ADP
bam-7218	943	2	the	the	DET
bam-7218	943	3	contrary	contrary	NOUN
bam-7218	943	4	,	,	PUNCT
bam-7218	943	5	muscle	muscle	NOUN
bam-7218	943	6	igf-1ea	igf-1ea	PROPN
bam-7218	943	7	,	,	PUNCT
bam-7218	943	8	igf-1eb	igf-1eb	PROPN
bam-7218	943	9	,	,	PUNCT
bam-7218	943	10	igf-1ec	igf-1ec	NOUN
bam-7218	943	11	myogenin	myogenin	ADJ
bam-7218	943	12	and	and	CCONJ
bam-7218	943	13	cyclin	cyclin	PROPN
bam-7218	943	14	d1	d1	PROPN
bam-7218	943	15	mrna	mrna	PROPN
bam-7218	943	16	content	content	PROPN
bam-7218	943	17	was	be	AUX
bam-7218	943	18	down	down	ADV
bam-7218	943	19	-	-	PUNCT
bam-7218	943	20	regulated	regulate	VERB
bam-7218	943	21	2h	2h	NUM
bam-7218	943	22	after	after	ADP
bam-7218	943	23	the	the	DET
bam-7218	943	24	exercise	exercise	NOUN
bam-7218	943	25	bout	bout	NOUN
bam-7218	943	26	.	.	PUNCT
bam-7218	944	1	muscle	muscle	NOUN
bam-7218	944	2	ikb	ikb	PROPN
bam-7218	944	3	-	-	PUNCT
bam-7218	944	4	α	α	NOUN
bam-7218	944	5	,	,	PUNCT
bam-7218	944	6	il-6r	il-6r	PROPN
bam-7218	944	7	and	and	CCONJ
bam-7218	944	8	mrf-4	mrf-4	PUNCT
bam-7218	944	9	and	and	CCONJ
bam-7218	944	10	pbmc	pbmc	PROPN
bam-7218	944	11	tnf	tnf	PROPN
bam-7218	944	12	-	-	PUNCT
bam-7218	944	13	α	α	PROPN
bam-7218	944	14	,	,	PUNCT
bam-7218	944	15	il-6	il-6	NUM
bam-7218	944	16	andil-6r	andil-6r	PUNCT
bam-7218	944	17	mrna	mrna	PROPN
bam-7218	944	18	levels	level	NOUN
bam-7218	944	19	were	be	AUX
bam-7218	944	20	unaffected	unaffected	ADJ
bam-7218	944	21	.	.	PUNCT
bam-7218	945	1	in	in	ADP
bam-7218	945	2	conclusion	conclusion	NOUN
bam-7218	945	3	,	,	PUNCT
bam-7218	945	4	a	a	DET
bam-7218	945	5	single	single	ADJ
bam-7218	945	6	isoinertial	isoinertial	ADJ
bam-7218	945	7	exercise	exercise	NOUN
bam-7218	945	8	session	session	NOUN
bam-7218	945	9	increased	increase	VERB
bam-7218	945	10	serum	serum	NOUN
bam-7218	945	11	markers	marker	NOUN
bam-7218	945	12	of	of	ADP
bam-7218	945	13	muscle	muscle	NOUN
bam-7218	945	14	damage	damage	NOUN
bam-7218	945	15	(	(	PUNCT
bam-7218	945	16	ckm	ckm	NOUN
bam-7218	945	17	and	and	CCONJ
bam-7218	945	18	il-6	il-6	NUM
bam-7218	945	19	)	)	PUNCT
bam-7218	945	20	and	and	CCONJ
bam-7218	945	21	pro	pro	ADJ
bam-7218	945	22	-	-	ADJ
bam-7218	945	23	inflammatory	inflammatory	ADJ
bam-7218	945	24	gene	gene	NOUN
bam-7218	945	25	expression	expression	NOUN
bam-7218	945	26	in	in	ADP
bam-7218	945	27	muscle	muscle	NOUN
bam-7218	945	28	and	and	CCONJ
bam-7218	945	29	pbmc	pbmc	NOUN
bam-7218	945	30	of	of	ADP
bam-7218	945	31	healthy	healthy	ADJ
bam-7218	945	32	,	,	PUNCT
bam-7218	945	33	recreationally	recreationally	ADV
bam-7218	945	34	resistance	resistance	NOUN
bam-7218	945	35	-	-	PUNCT
bam-7218	945	36	trained	train	VERB
bam-7218	945	37	men	man	NOUN
bam-7218	945	38	.	.	PUNCT
bam-7218	946	1	on	on	ADP
bam-7218	946	2	the	the	DET
bam-7218	946	3	contrary	contrary	NOUN
bam-7218	946	4	,	,	PUNCT
bam-7218	946	5	the	the	DET
bam-7218	946	6	mrna	mrna	PROPN
bam-7218	946	7	level	level	NOUN
bam-7218	946	8	of	of	ADP
bam-7218	946	9	genes	gene	NOUN
bam-7218	946	10	related	relate	VERB
bam-7218	946	11	to	to	ADP
bam-7218	946	12	muscle	muscle	NOUN
bam-7218	946	13	growth	growth	NOUN
bam-7218	946	14	and	and	CCONJ
bam-7218	946	15	repair	repair	NOUN
bam-7218	946	16	decreased	decrease	VERB
bam-7218	946	17	2h	2h	NUM
bam-7218	946	18	post	post	ADJ
bam-7218	946	19	-	-	NOUN
bam-7218	946	20	exercise	exercise	ADJ
bam-7218	946	21	,	,	PUNCT
bam-7218	946	22	suggesting	suggest	VERB
bam-7218	946	23	that	that	SCONJ
bam-7218	946	24	these	these	DET
bam-7218	946	25	processes	process	NOUN
bam-7218	946	26	had	have	AUX
bam-7218	946	27	not	not	PART
bam-7218	946	28	yet	yet	ADV
bam-7218	946	29	been	be	AUX
bam-7218	946	30	activated	activate	VERB
bam-7218	946	31	while	while	SCONJ
bam-7218	946	32	those	those	PRON
bam-7218	946	33	responding	respond	VERB
bam-7218	946	34	to	to	ADP
bam-7218	946	35	muscular	muscular	ADJ
bam-7218	946	36	injury	injury	NOUN
bam-7218	946	37	were	be	AUX
bam-7218	946	38	prevalent	prevalent	ADJ
bam-7218	946	39	.	.	PUNCT
bam-7218	947	1	accordingly	accordingly	ADV
bam-7218	947	2	,	,	PUNCT
bam-7218	947	3	the	the	DET
bam-7218	947	4	plasma	plasma	NOUN
bam-7218	947	5	levels	level	NOUN
bam-7218	947	6	of	of	ADP
bam-7218	947	7	igf-1	igf-1	ADV
bam-7218	947	8	increased	increase	VERB
bam-7218	947	9	only	only	ADV
bam-7218	947	10	after	after	ADP
bam-7218	947	11	24	24	NUM
bam-7218	947	12	h	h	NOUN
bam-7218	947	13	post	post	NOUN
bam-7218	947	14	-	-	NOUN
bam-7218	947	15	exercise	exercise	NOUN
bam-7218	947	16	.	.	PUNCT
bam-7218	948	1	these	these	DET
bam-7218	948	2	results	result	NOUN
bam-7218	948	3	indicate	indicate	VERB
bam-7218	948	4	early	early	ADJ
bam-7218	948	5	molecular	molecular	ADJ
bam-7218	948	6	adaptations	adaptation	NOUN
bam-7218	948	7	of	of	ADP
bam-7218	948	8	skeletal	skeletal	ADJ
bam-7218	948	9	muscle	muscle	NOUN
bam-7218	948	10	to	to	ADP
bam-7218	948	11	loading	loading	NOUN
bam-7218	948	12	,	,	PUNCT
bam-7218	948	13	supporting	support	VERB
bam-7218	948	14	the	the	DET
bam-7218	948	15	hypothesis	hypothesis	NOUN
bam-7218	948	16	that	that	PRON
bam-7218	948	17	eccentric	eccentric	ADJ
bam-7218	948	18	-	-	PUNCT
bam-7218	948	19	overload	overload	NOUN
bam-7218	948	20	inferred	infer	VERB
bam-7218	948	21	by	by	ADP
bam-7218	948	22	isoinertial	isoinertial	ADJ
bam-7218	948	23	machinery	machinery	NOUN
bam-7218	948	24	offers	offer	VERB
bam-7218	948	25	a	a	DET
bam-7218	948	26	potent	potent	ADJ
bam-7218	948	27	stimulus	stimulus	NOUN
bam-7218	948	28	to	to	PART
bam-7218	948	29	critically	critically	ADV
bam-7218	948	30	optimize	optimize	VERB
bam-7218	948	31	the	the	DET
bam-7218	948	32	benefits	benefit	NOUN
bam-7218	948	33	of	of	ADP
bam-7218	948	34	resistance	resistance	NOUN
bam-7218	948	35	exercise	exercise	NOUN
bam-7218	948	36	.	.	PUNCT
bam-7218	949	1	p.13	p.13	AUX
bam-7218	949	2	unraveling	unravel	VERB
bam-7218	949	3	muscle	muscle	NOUN
bam-7218	949	4	slowness	slowness	NOUN
bam-7218	949	5	in	in	ADP
bam-7218	949	6	nem6	nem6	PROPN
bam-7218	949	7	myopathy	myopathy	ADJ
bam-7218	949	8	:	:	PUNCT
bam-7218	949	9	a	a	DET
bam-7218	949	10	key	key	ADJ
bam-7218	949	11	role	role	NOUN
bam-7218	949	12	for	for	ADP
bam-7218	949	13	the	the	DET
bam-7218	949	14	skeletal	skeletal	ADJ
bam-7218	949	15	muscle	muscle	NOUN
bam-7218	949	16	thin	thin	ADJ
bam-7218	949	17	filament	filament	NOUN
bam-7218	949	18	josine	josine	NOUN
bam-7218	949	19	de	de	ADP
bam-7218	949	20	winter	winter	X
bam-7218	949	21	(	(	PUNCT
bam-7218	949	22	a	a	NOUN
bam-7218	949	23	)	)	PUNCT
bam-7218	949	24	,	,	PUNCT
bam-7218	949	25	joery	joery	NOUN
bam-7218	949	26	molenaar	molenaar	NOUN
bam-7218	949	27	(	(	PUNCT
bam-7218	949	28	b	b	NOUN
bam-7218	949	29	)	)	PUNCT
bam-7218	949	30	,	,	PUNCT
bam-7218	949	31	manuela	manuela	PROPN
bam-7218	949	32	marabita	marabita	PROPN
bam-7218	949	33	(	(	PUNCT
bam-7218	949	34	c	c	NOUN
bam-7218	949	35	)	)	PUNCT
bam-7218	949	36	,	,	PUNCT
bam-7218	949	37	menne	menne	PROPN
bam-7218	949	38	van	van	PROPN
bam-7218	949	39	willigenburg	willigenburg	NOUN
bam-7218	949	40	(	(	PUNCT
bam-7218	949	41	a	a	X
bam-7218	949	42	)	)	PUNCT
bam-7218	949	43	,	,	PUNCT
bam-7218	949	44	stefan	stefan	PROPN
bam-7218	949	45	conijn	conijn	PROPN
bam-7218	949	46	(	(	PUNCT
bam-7218	949	47	a	a	NOUN
bam-7218	949	48	)	)	PUNCT
bam-7218	949	49	,	,	PUNCT
bam-7218	949	50	barbara	barbara	PROPN
bam-7218	949	51	joureau	joureau	PROPN
bam-7218	949	52	(	(	PUNCT
bam-7218	949	53	a	a	X
bam-7218	949	54	)	)	PUNCT
bam-7218	949	55	,	,	PUNCT
bam-7218	949	56	ger	ger	NOUN
bam-7218	949	57	stienen	stienen	NOUN
bam-7218	949	58	(	(	PUNCT
bam-7218	949	59	a	a	DET
bam-7218	949	60	,	,	PUNCT
bam-7218	949	61	d	d	NOUN
bam-7218	949	62	)	)	PUNCT
bam-7218	949	63	,	,	PUNCT
bam-7218	949	64	saskia	saskia	NOUN
bam-7218	949	65	lassche	lassche	NOUN
bam-7218	949	66	(	(	PUNCT
bam-7218	949	67	b	b	NOUN
bam-7218	949	68	)	)	PUNCT
bam-7218	949	69	,	,	PUNCT
bam-7218	949	70	thomas	thomas	PROPN
bam-7218	949	71	irving	irving	PROPN
bam-7218	949	72	(	(	PUNCT
bam-7218	949	73	e	e	NOUN
bam-7218	949	74	)	)	PUNCT
bam-7218	949	75	,	,	PUNCT
bam-7218	949	76	ken	ken	PROPN
bam-7218	949	77	campbell	campbell	PROPN
bam-7218	949	78	(	(	PUNCT
bam-7218	949	79	f	f	PROPN
bam-7218	949	80	)	)	PUNCT
bam-7218	949	81	,	,	PUNCT
bam-7218	949	82	baziel	baziel	VERB
bam-7218	949	83	van	van	PROPN
bam-7218	949	84	engelen	engelen	PROPN
bam-7218	949	85	(	(	PUNCT
bam-7218	949	86	b	b	NOUN
bam-7218	949	87	)	)	PUNCT
bam-7218	949	88	,	,	PUNCT
bam-7218	949	89	bert	bert	PROPN
bam-7218	949	90	blaauw	blaauw	NOUN
bam-7218	949	91	(	(	PUNCT
bam-7218	949	92	c	c	NOUN
bam-7218	949	93	)	)	PUNCT
bam-7218	949	94	,	,	PUNCT
bam-7218	949	95	nicol	nicol	PROPN
bam-7218	949	96	voermans	voerman	NOUN
bam-7218	949	97	(	(	PUNCT
bam-7218	949	98	b	b	NOUN
bam-7218	949	99	)	)	PUNCT
bam-7218	949	100	,	,	PUNCT
bam-7218	949	101	coen	coen	PROPN
bam-7218	949	102	ottenheijm	ottenheijm	PROPN
bam-7218	949	103	(	(	PUNCT
bam-7218	949	104	a	a	NOUN
bam-7218	949	105	)	)	PUNCT
bam-7218	949	106	(	(	PUNCT
bam-7218	949	107	a	a	PRON
bam-7218	949	108	)	)	PUNCT
bam-7218	949	109	dept	dept	NOUN
bam-7218	949	110	.	.	PROPN
bam-7218	949	111	of	of	ADP
bam-7218	949	112	physiology	physiology	NOUN
bam-7218	949	113	,	,	PUNCT
bam-7218	949	114	vu	vu	PROPN
bam-7218	949	115	university	university	PROPN
bam-7218	949	116	medical	medical	ADJ
bam-7218	949	117	center	center	NOUN
bam-7218	949	118	,	,	PUNCT
bam-7218	949	119	amsterdam	amsterdam	PROPN
bam-7218	949	120	;	;	PUNCT
bam-7218	949	121	(	(	PUNCT
bam-7218	949	122	b	b	X
bam-7218	949	123	)	)	PUNCT
bam-7218	949	124	dept	dept	NOUN
bam-7218	949	125	.	.	PROPN
bam-7218	949	126	of	of	ADP
bam-7218	949	127	neurology	neurology	PROPN
bam-7218	949	128	,	,	PUNCT
bam-7218	949	129	radboud	radboud	PROPN
bam-7218	949	130	university	university	PROPN
bam-7218	949	131	medical	medical	ADJ
bam-7218	949	132	centre	centre	NOUN
bam-7218	949	133	,	,	PUNCT
bam-7218	949	134	nijmegen	nijmegen	PROPN
bam-7218	949	135	,	,	PUNCT
bam-7218	949	136	the	the	DET
bam-7218	949	137	netherland;(c	netherland;(c	PROPN
bam-7218	949	138	)	)	PUNCT
bam-7218	949	139	venetian	venetian	ADJ
bam-7218	949	140	institute	institute	NOUN
bam-7218	949	141	of	of	ADP
bam-7218	949	142	molecular	molecular	ADJ
bam-7218	949	143	medicine	medicine	NOUN
bam-7218	949	144	,	,	PUNCT
bam-7218	949	145	university	university	NOUN
bam-7218	949	146	of	of	ADP
bam-7218	949	147	padova	padova	PROPN
bam-7218	949	148	,	,	PUNCT
bam-7218	949	149	italy	italy	PROPN
bam-7218	949	150	;	;	PUNCT
bam-7218	949	151	(	(	PUNCT
bam-7218	949	152	d	d	X
bam-7218	949	153	)	)	PUNCT
bam-7218	949	154	dept	dept	NOUN
bam-7218	949	155	.	.	PROPN
bam-7218	949	156	of	of	ADP
bam-7218	949	157	physics	physics	PROPN
bam-7218	949	158	and	and	CCONJ
bam-7218	949	159	astronomy	astronomy	NOUN
bam-7218	949	160	,	,	PUNCT
bam-7218	949	161	vu	vu	X
bam-7218	949	162	university	university	NOUN
bam-7218	949	163	,	,	PUNCT
bam-7218	949	164	amsterdam	amsterdam	PROPN
bam-7218	949	165	,	,	PUNCT
bam-7218	949	166	the	the	DET
bam-7218	949	167	netherlands	netherlands	PROPN
bam-7218	949	168	;	;	PUNCT
bam-7218	949	169	(	(	PUNCT
bam-7218	949	170	e	e	NOUN
bam-7218	949	171	)	)	PUNCT
bam-7218	949	172	biocat	biocat	PROPN
bam-7218	949	173	,	,	PUNCT
bam-7218	949	174	illinois	illinois	PROPN
bam-7218	949	175	institute	institute	PROPN
bam-7218	949	176	of	of	ADP
bam-7218	949	177	technology	technology	PROPN
bam-7218	949	178	,	,	PUNCT
bam-7218	949	179	chicago	chicago	PROPN
bam-7218	949	180	,	,	PUNCT
bam-7218	949	181	il	il	PROPN
bam-7218	949	182	;	;	PUNCT
bam-7218	949	183	(	(	PUNCT
bam-7218	949	184	f	f	X
bam-7218	949	185	)	)	PUNCT
bam-7218	949	186	dept	dept	NOUN
bam-7218	949	187	of	of	ADP
bam-7218	949	188	physiology	physiology	NOUN
bam-7218	949	189	and	and	CCONJ
bam-7218	949	190	division	division	NOUN
bam-7218	949	191	of	of	ADP
bam-7218	949	192	cardiovascular	cardiovascular	ADJ
bam-7218	949	193	medicine	medicine	NOUN
bam-7218	949	194	,	,	PUNCT
bam-7218	949	195	university	university	NOUN
bam-7218	949	196	of	of	ADP
bam-7218	949	197	kentucky	kentucky	PROPN
bam-7218	949	198	,	,	PUNCT
bam-7218	949	199	lexington	lexington	PROPN
bam-7218	949	200	,	,	PUNCT
bam-7218	949	201	ky	ky	PROPN
bam-7218	949	202	,	,	PUNCT
bam-7218	949	203	usa	usa	PROPN
bam-7218	949	204	e	e	PROPN
bam-7218	949	205	-	-	NOUN
bam-7218	949	206	mail	mail	NOUN
bam-7218	949	207	:	:	PUNCT
bam-7218	949	208	jm.dewinter@vumc.nl	jm.dewinter@vumc.nl	PROPN
bam-7218	949	209	nemaline	nemaline	PROPN
bam-7218	949	210	myopathy	myopathy	ADJ
bam-7218	949	211	(	(	PUNCT
bam-7218	949	212	nm	nm	NOUN
bam-7218	949	213	)	)	PUNCT
bam-7218	949	214	is	be	AUX
bam-7218	949	215	among	among	ADP
bam-7218	949	216	the	the	DET
bam-7218	949	217	most	most	ADV
bam-7218	949	218	common	common	ADJ
bam-7218	949	219	non	non	ADJ
bam-7218	949	220	-	-	ADJ
bam-7218	949	221	dystrophic	dystrophic	ADJ
bam-7218	949	222	congenital	congenital	ADJ
bam-7218	949	223	myopathies	myopathy	NOUN
bam-7218	949	224	.	.	PUNCT
bam-7218	950	1	recently	recently	ADV
bam-7218	950	2	,	,	PUNCT
bam-7218	950	3	a	a	DET
bam-7218	950	4	novel	novel	ADJ
bam-7218	950	5	implicated	implicate	VERB
bam-7218	950	6	gene	gene	NOUN
bam-7218	950	7	was	be	AUX
bam-7218	950	8	discovered	discover	VERB
bam-7218	950	9	kbtbd13	kbtbd13	NOUN
bam-7218	950	10	.	.	PUNCT
bam-7218	951	1	nm	nm	PRON
bam-7218	951	2	patients	patient	NOUN
bam-7218	951	3	with	with	ADP
bam-7218	951	4	mutations	mutation	NOUN
bam-7218	951	5	in	in	ADP
bam-7218	951	6	kbtbd13	kbtbd13	PROPN
bam-7218	951	7	(	(	PUNCT
bam-7218	951	8	nem6	nem6	PROPN
bam-7218	951	9	)	)	PUNCT
bam-7218	951	10	exhibit	exhibit	VERB
bam-7218	951	11	muscle	muscle	NOUN
bam-7218	951	12	weakness	weakness	NOUN
bam-7218	951	13	and	and	CCONJ
bam-7218	951	14	a	a	DET
bam-7218	951	15	typical	typical	ADJ
bam-7218	951	16	muscle	muscle	NOUN
bam-7218	951	17	slowness	slowness	NOUN
bam-7218	951	18	.	.	PUNCT
bam-7218	952	1	here	here	ADV
bam-7218	952	2	,	,	PUNCT
bam-7218	952	3	we	we	PRON
bam-7218	952	4	aim	aim	VERB
bam-7218	952	5	to	to	PART
bam-7218	952	6	gain	gain	VERB
bam-7218	952	7	insight	insight	NOUN
bam-7218	952	8	in	in	ADP
bam-7218	952	9	the	the	DET
bam-7218	952	10	pathophysiology	pathophysiology	NOUN
bam-7218	952	11	of	of	ADP
bam-7218	952	12	nem6	nem6	PROPN
bam-7218	952	13	myopathy	myopathy	ADJ
bam-7218	952	14	muscle	muscle	NOUN
bam-7218	952	15	slowness	slowness	NOUN
bam-7218	952	16	.	.	PUNCT
bam-7218	953	1	in	in	ADP
bam-7218	953	2	vivo	vivo	ADJ
bam-7218	953	3	muscle	muscle	NOUN
bam-7218	953	4	relaxation	relaxation	NOUN
bam-7218	953	5	was	be	AUX
bam-7218	953	6	assessed	assess	VERB
bam-7218	953	7	using	use	VERB
bam-7218	953	8	transcranial	transcranial	ADJ
bam-7218	953	9	magnetic	magnetic	ADJ
bam-7218	953	10	stimulation	stimulation	NOUN
bam-7218	953	11	(	(	PUNCT
bam-7218	953	12	tms	tms	PROPN
bam-7218	953	13	)	)	PUNCT
bam-7218	953	14	in	in	ADP
bam-7218	953	15	nem6	nem6	PROPN
bam-7218	953	16	patients	patient	NOUN
bam-7218	953	17	(	(	PUNCT
bam-7218	953	18	n=10	n=10	NOUN
bam-7218	953	19	)	)	PUNCT
bam-7218	953	20	and	and	CCONJ
bam-7218	953	21	controls	control	NOUN
bam-7218	953	22	(	(	PUNCT
bam-7218	953	23	ctrl	ctrl	NOUN
bam-7218	953	24	)	)	PUNCT
bam-7218	953	25	(	(	PUNCT
bam-7218	953	26	n=24	n=24	PROPN
bam-7218	953	27	)	)	PUNCT
bam-7218	953	28	.	.	PUNCT
bam-7218	954	1	calcium	calcium	NOUN
bam-7218	954	2	-	-	PUNCT
bam-7218	954	3	handling	handle	VERB
bam-7218	954	4	protein	protein	NOUN
bam-7218	954	5	levels	level	NOUN
bam-7218	954	6	were	be	AUX
bam-7218	954	7	determined	determine	VERB
bam-7218	954	8	in	in	ADP
bam-7218	954	9	skeletal	skeletal	ADJ
bam-7218	954	10	muscle	muscle	NOUN
bam-7218	954	11	biopsies	biopsy	NOUN
bam-7218	954	12	by	by	ADP
bam-7218	954	13	western	western	ADJ
bam-7218	954	14	blot	blot	NOUN
bam-7218	954	15	.	.	PUNCT
bam-7218	955	1	contractile	contractile	NOUN
bam-7218	955	2	parameters	parameter	NOUN
bam-7218	955	3	were	be	AUX
bam-7218	955	4	measured	measure	VERB
bam-7218	955	5	in	in	ADP
bam-7218	955	6	isolated	isolated	ADJ
bam-7218	955	7	single	single	ADJ
bam-7218	955	8	fibers	fiber	NOUN
bam-7218	955	9	and	and	CCONJ
bam-7218	955	10	in	in	ADP
bam-7218	955	11	myofibrils	myofibril	NOUN
bam-7218	955	12	that	that	PRON
bam-7218	955	13	were	be	AUX
bam-7218	955	14	isolated	isolate	VERB
bam-7218	955	15	from	from	ADP
bam-7218	955	16	skeletal	skeletal	ADJ
bam-7218	955	17	mailto:serena.contarelli@uniurb.it	mailto:serena.contarelli@uniurb.it	NOUN
bam-7218	955	18	mailto:jm.dewinter@vumc.nl	mailto:jm.dewinter@vumc.nl	PROPN
bam-7218	955	19	14	14	NUM
bam-7218	955	20	th	th	NOUN
bam-7218	955	21	iiim	iiim	NOUN
bam-7218	955	22	meeting	meeting	NOUN
bam-7218	955	23	,	,	PUNCT
bam-7218	955	24	assisi	assisi	PROPN
bam-7218	955	25	,	,	PUNCT
bam-7218	955	26	italy	italy	PROPN
bam-7218	955	27	october	october	PROPN
bam-7218	955	28	12	12	NUM
bam-7218	955	29	-	-	SYM
bam-7218	955	30	15	15	NUM
bam-7218	955	31	2017	2017	NUM
bam-7218	955	32	eur	eur	PROPN
bam-7218	955	33	j	j	PROPN
bam-7218	955	34	transl	transl	PROPN
bam-7218	955	35	myol	myol	ADV
bam-7218	955	36	27	27	NUM
bam-7218	955	37	(	(	PUNCT
bam-7218	955	38	4	4	NUM
bam-7218	955	39	):	):	SYM
bam-7218	955	40	185	185	NUM
bam-7218	955	41	-	-	SYM
bam-7218	955	42	224	224	NUM
bam-7218	955	43	214	214	NUM
bam-7218	955	44	muscle	muscle	NOUN
bam-7218	955	45	biopsies	biopsy	NOUN
bam-7218	955	46	.	.	PUNCT
bam-7218	956	1	next	next	ADV
bam-7218	956	2	,	,	PUNCT
bam-7218	956	3	the	the	DET
bam-7218	956	4	nanoscale	nanoscale	NOUN
bam-7218	956	5	structure	structure	NOUN
bam-7218	956	6	and	and	CCONJ
bam-7218	956	7	actomyosin	actomyosin	NOUN
bam-7218	956	8	interactions	interaction	NOUN
bam-7218	956	9	in	in	ADP
bam-7218	956	10	these	these	DET
bam-7218	956	11	muscle	muscle	NOUN
bam-7218	956	12	fibers	fiber	NOUN
bam-7218	956	13	were	be	AUX
bam-7218	956	14	studied	study	VERB
bam-7218	956	15	by	by	ADP
bam-7218	956	16	x	x	NOUN
bam-7218	956	17	-	-	NOUN
bam-7218	956	18	ray	ray	NOUN
bam-7218	956	19	diffraction	diffraction	NOUN
bam-7218	956	20	.	.	PUNCT
bam-7218	957	1	in	in	ADP
bam-7218	957	2	vivo	vivo	ADJ
bam-7218	957	3	tms	tms	PROPN
bam-7218	957	4	revealed	reveal	VERB
bam-7218	957	5	slower	slow	ADJ
bam-7218	957	6	muscle	muscle	NOUN
bam-7218	957	7	relaxation	relaxation	NOUN
bam-7218	957	8	in	in	ADP
bam-7218	957	9	nem6	nem6	NOUN
bam-7218	957	10	patients	patient	NOUN
bam-7218	957	11	.	.	PUNCT
bam-7218	958	1	the	the	DET
bam-7218	958	2	phosphorylated	phosphorylate	VERB
bam-7218	958	3	phospholamban	phospholamban	NOUN
bam-7218	958	4	/	/	SYM
bam-7218	958	5	phospholamban	phospholamban	NOUN
bam-7218	958	6	ratio	ratio	NOUN
bam-7218	958	7	was	be	AUX
bam-7218	958	8	lower	low	ADJ
bam-7218	958	9	in	in	ADP
bam-7218	958	10	nem6	nem6	PROPN
bam-7218	958	11	muscle	muscle	NOUN
bam-7218	958	12	biopsies	biopsy	NOUN
bam-7218	958	13	,	,	PUNCT
bam-7218	958	14	which	which	PRON
bam-7218	958	15	might	might	AUX
bam-7218	958	16	contribute	contribute	VERB
bam-7218	958	17	to	to	ADP
bam-7218	958	18	slower	slow	ADJ
bam-7218	958	19	calcium	calcium	NOUN
bam-7218	958	20	-	-	PUNCT
bam-7218	958	21	uptake	uptake	ADJ
bam-7218	958	22	.	.	PUNCT
bam-7218	959	1	relaxation	relaxation	NOUN
bam-7218	959	2	kinetics	kinetic	NOUN
bam-7218	959	3	of	of	ADP
bam-7218	959	4	both	both	DET
bam-7218	959	5	single	single	ADJ
bam-7218	959	6	muscle	muscle	NOUN
bam-7218	959	7	fibers	fiber	NOUN
bam-7218	959	8	as	as	ADV
bam-7218	959	9	well	well	ADV
bam-7218	959	10	as	as	ADP
bam-7218	959	11	individual	individual	ADJ
bam-7218	959	12	myofibrils	myofibril	NOUN
bam-7218	959	13	were	be	AUX
bam-7218	959	14	slower	slow	ADJ
bam-7218	959	15	in	in	ADP
bam-7218	959	16	nem6	nem6	NOUN
bam-7218	959	17	compared	compare	VERB
bam-7218	959	18	to	to	PART
bam-7218	959	19	ctrl	ctrl	VERB
bam-7218	959	20	.	.	PUNCT
bam-7218	960	1	x	x	X
bam-7218	960	2	-	-	PUNCT
bam-7218	960	3	ray	ray	NOUN
bam-7218	960	4	diffraction	diffraction	NOUN
bam-7218	960	5	studies	study	NOUN
bam-7218	960	6	show	show	VERB
bam-7218	960	7	that	that	SCONJ
bam-7218	960	8	the	the	DET
bam-7218	960	9	peak	peak	NOUN
bam-7218	960	10	position	position	NOUN
bam-7218	960	11	of	of	ADP
bam-7218	960	12	the	the	DET
bam-7218	960	13	actin	actin	NOUN
bam-7218	960	14	layer	layer	NOUN
bam-7218	960	15	line	line	NOUN
bam-7218	960	16	6	6	NUM
bam-7218	960	17	was	be	AUX
bam-7218	960	18	reduced	reduce	VERB
bam-7218	960	19	in	in	ADP
bam-7218	960	20	nem6	nem6	NOUN
bam-7218	960	21	compared	compare	VERB
bam-7218	960	22	to	to	PART
bam-7218	960	23	ctrl	ctrl	VERB
bam-7218	960	24	,	,	PUNCT
bam-7218	960	25	suggesting	suggest	VERB
bam-7218	960	26	a	a	DET
bam-7218	960	27	compressed	compressed	ADJ
bam-7218	960	28	,	,	PUNCT
bam-7218	960	29	stiffer	stiffer	ADJ
bam-7218	960	30	thin	thin	ADJ
bam-7218	960	31	filament	filament	NOUN
bam-7218	960	32	.	.	PUNCT
bam-7218	961	1	modelling	modelling	NOUN
bam-7218	961	2	of	of	ADP
bam-7218	961	3	sarcomere	sarcomere	ADJ
bam-7218	961	4	kinetics	kinetic	NOUN
bam-7218	961	5	revealed	reveal	VERB
bam-7218	961	6	that	that	SCONJ
bam-7218	961	7	a	a	DET
bam-7218	961	8	stiffer	stiff	ADJ
bam-7218	961	9	thin	thin	ADJ
bam-7218	961	10	filament	filament	NOUN
bam-7218	961	11	slows	slow	VERB
bam-7218	961	12	muscle	muscle	NOUN
bam-7218	961	13	relaxation	relaxation	NOUN
bam-7218	961	14	.	.	PUNCT
bam-7218	962	1	here	here	ADV
bam-7218	962	2	,	,	PUNCT
bam-7218	962	3	we	we	PRON
bam-7218	962	4	studied	study	VERB
bam-7218	962	5	the	the	DET
bam-7218	962	6	pathophysiology	pathophysiology	NOUN
bam-7218	962	7	of	of	ADP
bam-7218	962	8	muscle	muscle	NOUN
bam-7218	962	9	slowness	slowness	NOUN
bam-7218	962	10	in	in	ADP
bam-7218	962	11	nem6	nem6	NOUN
bam-7218	962	12	patients	patient	NOUN
bam-7218	962	13	.	.	PUNCT
bam-7218	963	1	we	we	PRON
bam-7218	963	2	used	use	VERB
bam-7218	963	3	a	a	DET
bam-7218	963	4	top	top	ADJ
bam-7218	963	5	-	-	PUNCT
bam-7218	963	6	to	to	ADP
bam-7218	963	7	-	-	PUNCT
bam-7218	963	8	bottom	bottom	NOUN
bam-7218	963	9	approach	approach	NOUN
bam-7218	963	10	:	:	PUNCT
bam-7218	963	11	from	from	ADP
bam-7218	963	12	the	the	DET
bam-7218	963	13	patient	patient	NOUN
bam-7218	963	14	in	in	ADP
bam-7218	963	15	vivo	vivo	ADJ
bam-7218	963	16	level	level	NOUN
bam-7218	963	17	to	to	ADP
bam-7218	963	18	the	the	DET
bam-7218	963	19	nanoscale	nanoscale	NOUN
bam-7218	963	20	acto	acto	PROPN
bam-7218	963	21	-	-	PUNCT
bam-7218	963	22	myosin	myosin	PROPN
bam-7218	963	23	in	in	ADP
bam-7218	963	24	vitro	vitro	X
bam-7218	963	25	level	level	NOUN
bam-7218	963	26	.	.	PUNCT
bam-7218	964	1	the	the	DET
bam-7218	964	2	data	datum	NOUN
bam-7218	964	3	suggest	suggest	VERB
bam-7218	964	4	that	that	SCONJ
bam-7218	964	5	changes	change	NOUN
bam-7218	964	6	in	in	ADP
bam-7218	964	7	the	the	DET
bam-7218	964	8	skeletal	skeletal	ADJ
bam-7218	964	9	muscle	muscle	NOUN
bam-7218	964	10	thin	thin	ADJ
bam-7218	964	11	filament	filament	NOUN
bam-7218	964	12	level	level	NOUN
bam-7218	964	13	contribute	contribute	VERB
bam-7218	964	14	to	to	ADP
bam-7218	964	15	the	the	DET
bam-7218	964	16	clinical	clinical	ADJ
bam-7218	964	17	phenotype	phenotype	NOUN
bam-7218	964	18	of	of	ADP
bam-7218	964	19	nem6	nem6	PROPN
bam-7218	964	20	.	.	PUNCT
bam-7218	965	1	p.14	p.14	X
bam-7218	965	2	zinc	zinc	NOUN
bam-7218	965	3	finger	finger	NOUN
bam-7218	965	4	e	e	PROPN
bam-7218	965	5	-	-	NOUN
bam-7218	965	6	box	box	NOUN
bam-7218	965	7	-	-	PUNCT
bam-7218	965	8	binding	bind	VERB
bam-7218	965	9	homeobox	homeobox	NOUN
bam-7218	965	10	2	2	NUM
bam-7218	965	11	a	a	DET
bam-7218	965	12	new	new	ADJ
bam-7218	965	13	player	player	NOUN
bam-7218	965	14	in	in	ADP
bam-7218	965	15	skeletal	skeletal	ADJ
bam-7218	965	16	muscle	muscle	NOUN
bam-7218	965	17	differentiation	differentiation	NOUN
bam-7218	965	18	ester	ester	NOUN
bam-7218	965	19	sara	sara	PROPN
bam-7218	965	20	di	di	PROPN
bam-7218	965	21	filippo	filippo	PROPN
bam-7218	965	22	(	(	PUNCT
bam-7218	965	23	a	a	DET
bam-7218	965	24	,	,	PUNCT
bam-7218	965	25	b	b	NOUN
bam-7218	965	26	,	,	PUNCT
bam-7218	965	27	c	c	NOUN
bam-7218	965	28	,	,	PUNCT
bam-7218	965	29	d	d	NOUN
bam-7218	965	30	)	)	PUNCT
bam-7218	965	31	,	,	PUNCT
bam-7218	965	32	giorgia	giorgia	PROPN
bam-7218	965	33	giacomazzi	giacomazzi	PROPN
bam-7218	965	34	(	(	PUNCT
bam-7218	965	35	c	c	X
bam-7218	965	36	,	,	PUNCT
bam-7218	965	37	d	d	NOUN
bam-7218	965	38	)	)	PUNCT
bam-7218	965	39	,	,	PUNCT
bam-7218	965	40	domiziana	domiziana	NOUN
bam-7218	965	41	costamagna	costamagna	NOUN
bam-7218	965	42	(	(	PUNCT
bam-7218	965	43	c	c	X
bam-7218	965	44	,	,	PUNCT
bam-7218	965	45	d	d	NOUN
bam-7218	965	46	)	)	PUNCT
bam-7218	965	47	,	,	PUNCT
bam-7218	965	48	danny	danny	PROPN
bam-7218	965	49	huylebroeck	huylebroeck	NOUN
bam-7218	965	50	(	(	PUNCT
bam-7218	965	51	d	d	NOUN
bam-7218	965	52	,	,	PUNCT
bam-7218	965	53	e	e	NOUN
bam-7218	965	54	)	)	PUNCT
bam-7218	965	55	,	,	PUNCT
bam-7218	965	56	stefania	stefania	NOUN
bam-7218	965	57	fulle	fulle	ADV
bam-7218	965	58	(	(	PUNCT
bam-7218	965	59	a	a	DET
bam-7218	965	60	,	,	PUNCT
bam-7218	965	61	b	b	NOUN
bam-7218	965	62	,	,	PUNCT
bam-7218	965	63	c	c	NOUN
bam-7218	965	64	)	)	PUNCT
bam-7218	965	65	,	,	PUNCT
bam-7218	965	66	maurilio	maurilio	NOUN
bam-7218	965	67	sampaolesi	sampaolesi	NOUN
bam-7218	965	68	(	(	PUNCT
bam-7218	965	69	c	c	X
bam-7218	965	70	,	,	PUNCT
bam-7218	965	71	d	d	NOUN
bam-7218	965	72	,	,	PUNCT
bam-7218	965	73	g	g	NOUN
bam-7218	965	74	)	)	PUNCT
bam-7218	965	75	(	(	PUNCT
bam-7218	965	76	a	a	X
bam-7218	965	77	)	)	PUNCT
bam-7218	965	78	dept	dept	NOUN
bam-7218	965	79	neuroscience	neuroscience	NOUN
bam-7218	965	80	imaging	imaging	NOUN
bam-7218	965	81	and	and	CCONJ
bam-7218	965	82	clinical	clinical	ADJ
bam-7218	965	83	sciences	science	NOUN
bam-7218	965	84	,	,	PUNCT
bam-7218	965	85	university	university	NOUN
bam-7218	965	86	“	"	PUNCT
bam-7218	965	87	g.	g.	PROPN
bam-7218	965	88	d'annunzio	d'annunzio	PROPN
bam-7218	965	89	”	"	PUNCT
bam-7218	965	90	of	of	ADP
bam-7218	965	91	chietipescara	chietipescara	PROPN
bam-7218	965	92	,	,	PUNCT
bam-7218	965	93	italy	italy	PROPN
bam-7218	965	94	;	;	PUNCT
bam-7218	965	95	(	(	PUNCT
bam-7218	965	96	b	b	X
bam-7218	965	97	)	)	PUNCT
bam-7218	965	98	ce.s.i	ce.s.i	PROPN
bam-7218	965	99	.	.	PUNCT
bam-7218	965	100	center	center	PROPN
bam-7218	965	101	for	for	ADP
bam-7218	965	102	research	research	NOUN
bam-7218	965	103	on	on	ADP
bam-7218	965	104	ageing	age	VERB
bam-7218	965	105	,	,	PUNCT
bam-7218	965	106	"	"	PUNCT
bam-7218	965	107	g.	g.	PROPN
bam-7218	965	108	d'annunzio	d'annunzio	PROPN
bam-7218	965	109	"	"	PUNCT
bam-7218	965	110	foundation	foundation	PROPN
bam-7218	965	111	,	,	PUNCT
bam-7218	965	112	chieti	chieti	PROPN
bam-7218	965	113	,	,	PUNCT
bam-7218	965	114	italy	italy	PROPN
bam-7218	965	115	;	;	PUNCT
bam-7218	965	116	(	(	PUNCT
bam-7218	965	117	c	c	X
bam-7218	965	118	)	)	PUNCT
bam-7218	965	119	interuniversity	interuniversity	NOUN
bam-7218	965	120	institute	institute	PROPN
bam-7218	965	121	of	of	ADP
bam-7218	965	122	myology	myology	NOUN
bam-7218	965	123	;	;	PUNCT
bam-7218	965	124	(	(	PUNCT
bam-7218	965	125	d	d	X
bam-7218	965	126	)	)	PUNCT
bam-7218	965	127	dept	dept	NOUN
bam-7218	965	128	development	development	NOUN
bam-7218	965	129	and	and	CCONJ
bam-7218	965	130	regeneration	regeneration	NOUN
bam-7218	965	131	,	,	PUNCT
bam-7218	965	132	ku	ku	PROPN
bam-7218	965	133	leuven	leuven	PROPN
bam-7218	965	134	,	,	PUNCT
bam-7218	965	135	belgium	belgium	NOUN
bam-7218	965	136	;	;	PUNCT
bam-7218	965	137	(	(	PUNCT
bam-7218	965	138	g	g	NOUN
bam-7218	965	139	)	)	PUNCT
bam-7218	965	140	
 	
 	SPACE
bam-7218	965	141	dept	dept	NOUN
bam-7218	965	142	of	of	ADP
bam-7218	965	143	cell	cell	NOUN
bam-7218	965	144	biology	biology	NOUN
bam-7218	965	145	,	,	PUNCT
bam-7218	965	146	erasmus	erasmus	PROPN
bam-7218	965	147	university	university	PROPN
bam-7218	965	148	medical	medical	ADJ
bam-7218	965	149	center	center	NOUN
bam-7218	965	150	,	,	PUNCT
bam-7218	965	151	rotterdam	rotterdam	PROPN
bam-7218	965	152	,	,	PUNCT
bam-7218	965	153	3015	3015	NUM
bam-7218	965	154	cn	cn	PROPN
bam-7218	965	155	,	,	PUNCT
bam-7218	965	156	the	the	DET
bam-7218	965	157	netherlands	netherlands	PROPN
bam-7218	965	158	;	;	PUNCT
bam-7218	965	159	(	(	PUNCT
bam-7218	965	160	g	g	NOUN
bam-7218	965	161	)	)	PUNCT
bam-7218	965	162	human	human	ADJ
bam-7218	965	163	anatomy	anatomy	NOUN
bam-7218	965	164	unit	unit	NOUN
bam-7218	965	165	,	,	PUNCT
bam-7218	965	166	dept	dept	NOUN
bam-7218	965	167	of	of	ADP
bam-7218	965	168	public	public	ADJ
bam-7218	965	169	health	health	NOUN
bam-7218	965	170	,	,	PUNCT
bam-7218	965	171	experimental	experimental	ADJ
bam-7218	965	172	and	and	CCONJ
bam-7218	965	173	forensic	forensic	ADJ
bam-7218	965	174	medicine	medicine	NOUN
bam-7218	965	175	,	,	PUNCT
bam-7218	965	176	university	university	NOUN
bam-7218	965	177	of	of	ADP
bam-7218	965	178	pavia	pavia	PROPN
bam-7218	965	179	,	,	PUNCT
bam-7218	965	180	pavia	pavia	PROPN
bam-7218	965	181	,	,	PUNCT
bam-7218	965	182	italy	italy	PROPN
bam-7218	965	183	.	.	PUNCT
bam-7218	966	1	e	e	X
bam-7218	966	2	-	-	NOUN
bam-7218	966	3	mail	mail	NOUN
bam-7218	966	4	:	:	PUNCT
bam-7218	966	5	esterpasquale@hotmail.it	esterpasquale@hotmail.it	X
bam-7218	966	6	myogenic	myogenic	ADJ
bam-7218	966	7	helix	helix	NOUN
bam-7218	966	8	-	-	PUNCT
bam-7218	966	9	loop	loop	NOUN
bam-7218	966	10	-	-	PUNCT
bam-7218	966	11	helix	helix	NOUN
bam-7218	966	12	proteins	protein	NOUN
bam-7218	966	13	such	such	ADJ
bam-7218	966	14	as	as	ADP
bam-7218	966	15	myod	myod	NOUN
bam-7218	966	16	,	,	PUNCT
bam-7218	966	17	myf5	myf5	NOUN
bam-7218	966	18	,	,	PUNCT
bam-7218	966	19	myogenin	myogenin	ADJ
bam-7218	966	20	and	and	CCONJ
bam-7218	966	21	mrf-4	mrf-4	ADV
bam-7218	966	22	regulate	regulate	VERB
bam-7218	966	23	the	the	DET
bam-7218	966	24	skeletal	skeletal	ADJ
bam-7218	966	25	muscle	muscle	NOUN
bam-7218	966	26	development	development	NOUN
bam-7218	966	27	and	and	CCONJ
bam-7218	966	28	differentiation	differentiation	NOUN
bam-7218	966	29	.	.	PUNCT
bam-7218	967	1	in	in	ADP
bam-7218	967	2	addition	addition	NOUN
bam-7218	967	3	,	,	PUNCT
bam-7218	967	4	a	a	DET
bam-7218	967	5	few	few	ADJ
bam-7218	967	6	zinc	zinc	NOUN
bam-7218	967	7	finger	finger	NOUN
bam-7218	967	8	proteins	protein	NOUN
bam-7218	967	9	have	have	AUX
bam-7218	967	10	been	be	AUX
bam-7218	967	11	described	describe	VERB
bam-7218	967	12	as	as	ADP
bam-7218	967	13	helixloop	helixloop	NOUN
bam-7218	967	14	-	-	PUNCT
bam-7218	967	15	helix	helix	NOUN
bam-7218	967	16	proteins	protein	NOUN
bam-7218	967	17	and	and	CCONJ
bam-7218	967	18	are	be	AUX
bam-7218	967	19	also	also	ADV
bam-7218	967	20	regulators	regulator	NOUN
bam-7218	967	21	of	of	ADP
bam-7218	967	22	muscle	muscle	NOUN
bam-7218	967	23	development	development	NOUN
bam-7218	967	24	and	and	CCONJ
bam-7218	967	25	muscle	muscle	NOUN
bam-7218	967	26	gene	gene	NOUN
bam-7218	967	27	expression	expression	NOUN
bam-7218	967	28	.	.	PUNCT
bam-7218	968	1	among	among	ADP
bam-7218	968	2	those	those	DET
bam-7218	968	3	proteins	protein	NOUN
bam-7218	968	4	,	,	PUNCT
bam-7218	968	5	zinc	zinc	NOUN
bam-7218	968	6	finger	finger	NOUN
bam-7218	968	7	e	e	NOUN
bam-7218	968	8	-	-	ADJ
bam-7218	968	9	boxbinding	boxbinde	VERB
bam-7218	968	10	homeobox	homeobox	NOUN
bam-7218	968	11	2	2	NUM
bam-7218	968	12	(	(	PUNCT
bam-7218	968	13	zeb2	zeb2	PROPN
bam-7218	968	14	,	,	PUNCT
bam-7218	968	15	also	also	ADV
bam-7218	968	16	known	know	VERB
bam-7218	968	17	as	as	ADP
bam-7218	968	18	smad	smad	PROPN
bam-7218	968	19	interacting	interact	VERB
bam-7218	968	20	protein	protein	NOUN
bam-7218	968	21	1	1	NUM
bam-7218	968	22	)	)	PUNCT
bam-7218	968	23	is	be	AUX
bam-7218	968	24	poorly	poorly	ADV
bam-7218	968	25	characterized	characterize	VERB
bam-7218	968	26	although	although	SCONJ
bam-7218	968	27	showing	show	VERB
bam-7218	968	28	similar	similar	ADJ
bam-7218	968	29	molecular	molecular	ADJ
bam-7218	968	30	characteristic	characteristic	NOUN
bam-7218	968	31	of	of	ADP
bam-7218	968	32	skeletal	skeletal	ADJ
bam-7218	968	33	muscle	muscle	NOUN
bam-7218	968	34	regulators	regulator	NOUN
bam-7218	968	35	(	(	PUNCT
bam-7218	968	36	1	1	NUM
bam-7218	968	37	)	)	PUNCT
bam-7218	968	38	.	.	PUNCT
bam-7218	969	1	in	in	ADP
bam-7218	969	2	this	this	DET
bam-7218	969	3	study	study	NOUN
bam-7218	969	4	we	we	PRON
bam-7218	969	5	investigate	investigate	VERB
bam-7218	969	6	whether	whether	SCONJ
bam-7218	969	7	zeb2	zeb2	PROPN
bam-7218	969	8	could	could	AUX
bam-7218	969	9	play	play	VERB
bam-7218	969	10	a	a	DET
bam-7218	969	11	role	role	NOUN
bam-7218	969	12	in	in	ADP
bam-7218	969	13	regulating	regulate	VERB
bam-7218	969	14	myogenic	myogenic	ADJ
bam-7218	969	15	differentiation	differentiation	NOUN
bam-7218	969	16	using	use	VERB
bam-7218	969	17	genetic	genetic	ADJ
bam-7218	969	18	tools	tool	NOUN
bam-7218	969	19	and	and	CCONJ
bam-7218	969	20	transgenic	transgenic	NOUN
bam-7218	969	21	mouse	mouse	NOUN
bam-7218	969	22	embryonic	embryonic	ADJ
bam-7218	969	23	stem	stem	NOUN
bam-7218	969	24	(	(	PUNCT
bam-7218	969	25	mes	me	NOUN
bam-7218	969	26	)	)	PUNCT
bam-7218	969	27	cells	cell	NOUN
bam-7218	969	28	.	.	PUNCT
bam-7218	970	1	we	we	PRON
bam-7218	970	2	report	report	VERB
bam-7218	970	3	that	that	SCONJ
bam-7218	970	4	mes	me	NOUN
bam-7218	970	5	cells	cell	NOUN
bam-7218	970	6	genetically	genetically	ADV
bam-7218	970	7	modified	modify	VERB
bam-7218	970	8	for	for	ADP
bam-7218	970	9	the	the	DET
bam-7218	970	10	absence	absence	NOUN
bam-7218	970	11	or	or	CCONJ
bam-7218	970	12	the	the	DET
bam-7218	970	13	overexpression	overexpression	NOUN
bam-7218	970	14	of	of	ADP
bam-7218	970	15	zeb2	zeb2	PROPN
bam-7218	970	16	maintain	maintain	VERB
bam-7218	970	17	pluripotency	pluripotency	NOUN
bam-7218	970	18	and	and	CCONJ
bam-7218	970	19	are	be	AUX
bam-7218	970	20	capable	capable	ADJ
bam-7218	970	21	to	to	PART
bam-7218	970	22	differentiate	differentiate	VERB
bam-7218	970	23	in	in	ADP
bam-7218	970	24	skeletal	skeletal	ADJ
bam-7218	970	25	muscle	muscle	NOUN
bam-7218	970	26	cells	cell	NOUN
bam-7218	970	27	.	.	PUNCT
bam-7218	971	1	however	however	ADV
bam-7218	971	2	,	,	PUNCT
bam-7218	971	3	zeb2	zeb2	PROPN
bam-7218	971	4	-	-	PUNCT
bam-7218	971	5	null	null	ADJ
bam-7218	971	6	mes	me	NOUN
bam-7218	971	7	cells	cell	NOUN
bam-7218	971	8	display	display	VERB
bam-7218	971	9	impaired	impair	VERB
bam-7218	971	10	myogenic	myogenic	ADJ
bam-7218	971	11	differentiation	differentiation	NOUN
bam-7218	971	12	and	and	CCONJ
bam-7218	971	13	more	more	ADJ
bam-7218	971	14	interestingly	interestingly	ADV
bam-7218	971	15	the	the	DET
bam-7218	971	16	overexpression	overexpression	NOUN
bam-7218	971	17	of	of	ADP
bam-7218	971	18	zeb2	zeb2	PROPN
bam-7218	971	19	in	in	ADP
bam-7218	971	20	both	both	DET
bam-7218	971	21	mes	me	NOUN
bam-7218	971	22	cells	cell	NOUN
bam-7218	971	23	and	and	CCONJ
bam-7218	971	24	adult	adult	NOUN
bam-7218	971	25	myogenic	myogenic	ADJ
bam-7218	971	26	cells	cell	NOUN
bam-7218	971	27	impacts	impact	NOUN
bam-7218	971	28	positively	positively	ADV
bam-7218	971	29	the	the	DET
bam-7218	971	30	myogenic	myogenic	ADJ
bam-7218	971	31	commitment	commitment	NOUN
bam-7218	971	32	in	in	ADP
bam-7218	971	33	vitro	vitro	X
bam-7218	971	34	and	and	CCONJ
bam-7218	971	35	in	in	ADP
bam-7218	971	36	vivo	vivo	NOUN
bam-7218	971	37	.	.	PUNCT
bam-7218	972	1	to	to	PART
bam-7218	972	2	deeper	deeply	ADV
bam-7218	972	3	investigate	investigate	VERB
bam-7218	972	4	the	the	DET
bam-7218	972	5	role	role	NOUN
bam-7218	972	6	of	of	ADP
bam-7218	972	7	zeb2	zeb2	PROPN
bam-7218	972	8	in	in	ADP
bam-7218	972	9	myogenic	myogenic	ADJ
bam-7218	972	10	differentiation	differentiation	NOUN
bam-7218	972	11	and	and	CCONJ
bam-7218	972	12	in	in	ADP
bam-7218	972	13	the	the	DET
bam-7218	972	14	context	context	NOUN
bam-7218	972	15	of	of	ADP
bam-7218	972	16	cellular	cellular	ADJ
bam-7218	972	17	microenvironment	microenvironment	NOUN
bam-7218	972	18	we	we	PRON
bam-7218	972	19	employed	employ	VERB
bam-7218	972	20	the	the	DET
bam-7218	972	21	single	single	ADJ
bam-7218	972	22	cell	cell	NOUN
bam-7218	972	23	sequencing	sequence	VERB
bam-7218	972	24	(	(	PUNCT
bam-7218	972	25	rna	rna	NOUN
bam-7218	972	26	-	-	PUNCT
bam-7218	972	27	seq	seq	NOUN
bam-7218	972	28	)	)	PUNCT
bam-7218	972	29	in	in	ADP
bam-7218	972	30	transgenic	transgenic	NOUN
bam-7218	972	31	mes	me	NOUN
bam-7218	972	32	cells	cell	NOUN
bam-7218	972	33	.	.	PUNCT
bam-7218	973	1	this	this	DET
bam-7218	973	2	technology	technology	NOUN
bam-7218	973	3	examines	examine	VERB
bam-7218	973	4	the	the	DET
bam-7218	973	5	sequence	sequence	NOUN
bam-7218	973	6	information	information	NOUN
bam-7218	973	7	from	from	ADP
bam-7218	973	8	individual	individual	ADJ
bam-7218	973	9	cells	cell	NOUN
bam-7218	973	10	with	with	ADP
bam-7218	973	11	optimized	optimize	VERB
bam-7218	973	12	next	next	ADJ
bam-7218	973	13	generation	generation	NOUN
bam-7218	973	14	sequencing	sequence	VERB
bam-7218	973	15	technologies	technology	NOUN
bam-7218	973	16	(	(	PUNCT
bam-7218	973	17	2	2	NUM
bam-7218	973	18	)	)	PUNCT
bam-7218	973	19	.	.	PUNCT
bam-7218	974	1	the	the	DET
bam-7218	974	2	single	single	ADJ
bam-7218	974	3	cell	cell	NOUN
bam-7218	974	4	rna	rna	NOUN
bam-7218	974	5	-	-	PUNCT
bam-7218	974	6	seq	seq	NOUN
bam-7218	974	7	analysis	analysis	NOUN
bam-7218	974	8	shows	show	VERB
bam-7218	974	9	that	that	SCONJ
bam-7218	974	10	myogenic	myogenic	ADJ
bam-7218	974	11	regulatory	regulatory	ADJ
bam-7218	974	12	factors	factor	NOUN
bam-7218	974	13	including	include	VERB
bam-7218	974	14	i	i	PROPN
bam-7218	974	15	d	d	PROPN
bam-7218	974	16	family	family	NOUN
bam-7218	974	17	and	and	CCONJ
bam-7218	974	18	smad	smad	PROPN
bam-7218	974	19	/	/	SYM
bam-7218	974	20	tgfβ	tgfβ	ADJ
bam-7218	974	21	pathway	pathway	NOUN
bam-7218	974	22	genes	gene	NOUN
bam-7218	974	23	are	be	AUX
bam-7218	974	24	affected	affect	VERB
bam-7218	974	25	by	by	ADP
bam-7218	974	26	the	the	DET
bam-7218	974	27	absence	absence	NOUN
bam-7218	974	28	or	or	CCONJ
bam-7218	974	29	the	the	DET
bam-7218	974	30	overexpression	overexpression	NOUN
bam-7218	974	31	of	of	ADP
bam-7218	974	32	zeb2	zeb2	PROPN
bam-7218	974	33	.	.	PUNCT
bam-7218	975	1	these	these	DET
bam-7218	975	2	findings	finding	NOUN
bam-7218	975	3	reveal	reveal	VERB
bam-7218	975	4	a	a	DET
bam-7218	975	5	critical	critical	ADJ
bam-7218	975	6	role	role	NOUN
bam-7218	975	7	of	of	ADP
bam-7218	975	8	zeb2	zeb2	PROPN
bam-7218	975	9	in	in	ADP
bam-7218	975	10	skeletal	skeletal	ADJ
bam-7218	975	11	muscle	muscle	NOUN
bam-7218	975	12	differentiation	differentiation	NOUN
bam-7218	975	13	,	,	PUNCT
bam-7218	975	14	thus	thus	ADV
bam-7218	975	15	providing	provide	VERB
bam-7218	975	16	a	a	DET
bam-7218	975	17	novel	novel	ADJ
bam-7218	975	18	possible	possible	ADJ
bam-7218	975	19	target	target	NOUN
bam-7218	975	20	to	to	PART
bam-7218	975	21	improve	improve	VERB
bam-7218	975	22	skeletal	skeletal	ADJ
bam-7218	975	23	muscle	muscle	NOUN
bam-7218	975	24	regeneration	regeneration	NOUN
bam-7218	975	25	in	in	ADP
bam-7218	975	26	muscle	muscle	NOUN
bam-7218	975	27	diseases	disease	NOUN
bam-7218	975	28	.	.	PUNCT
bam-7218	976	1	references	reference	NOUN
bam-7218	976	2	:	:	PUNCT
bam-7218	976	3	1	1	X
bam-7218	976	4	.	.	X
bam-7218	976	5	krempler	krempler	PROPN
bam-7218	976	6	a	a	PRON
bam-7218	976	7	,	,	PUNCT
bam-7218	976	8	brenig	brenig	PROPN
bam-7218	976	9	b.	b.	PROPN
bam-7218	976	10	zinc	zinc	NOUN
bam-7218	976	11	finger	finger	NOUN
bam-7218	976	12	proteins	protein	NOUN
bam-7218	976	13	:	:	PUNCT
bam-7218	976	14	watchdogs	watchdog	NOUN
bam-7218	976	15	in	in	ADP
bam-7218	976	16	muscle	muscle	NOUN
bam-7218	976	17	development	development	NOUN
bam-7218	976	18	.	.	PUNCT
bam-7218	977	1	mol	mol	ADP
bam-7218	977	2	gen	gen	PROPN
bam-7218	977	3	genet	genet	PROPN
bam-7218	977	4	.	.	PUNCT
bam-7218	978	1	1999	1999	NUM
bam-7218	978	2	mar	mar	PROPN
bam-7218	978	3	;	;	PUNCT
bam-7218	978	4	261(2	261(2	NUM
bam-7218	978	5	):	):	PUNCT
bam-7218	978	6	209	209	NUM
bam-7218	978	7	-	-	SYM
bam-7218	978	8	15	15	NUM
bam-7218	978	9	.	.	NOUN
bam-7218	978	10	2	2	NUM
bam-7218	978	11	.	.	X
bam-7218	978	12	andrews	andrews	PROPN
bam-7218	978	13	ts	ts	PROPN
bam-7218	978	14	,	,	PUNCT
bam-7218	978	15	hemberg	hemberg	PROPN
bam-7218	978	16	m.	m.	NOUN
bam-7218	978	17	identifying	identify	VERB
bam-7218	978	18	cell	cell	NOUN
bam-7218	978	19	populations	population	NOUN
bam-7218	978	20	with	with	ADP
bam-7218	978	21	scrnaseq	scrnaseq	NOUN
bam-7218	978	22	.	.	PUNCT
bam-7218	979	1	mol	mol	ADP
bam-7218	979	2	aspects	aspect	NOUN
bam-7218	979	3	med	me	VERB
bam-7218	979	4	.	.	PUNCT
bam-7218	979	5	2017	2017	NUM
bam-7218	979	6	jul	jul	PROPN
bam-7218	979	7	25	25	NUM
bam-7218	979	8	.	.	PUNCT
bam-7218	980	1	pii	pii	PROPN
bam-7218	980	2	:	:	PUNCT
bam-7218	980	3	s0098	s0098	NOUN
bam-7218	980	4	-	-	PUNCT
bam-7218	980	5	2997(17)30049	2997(17)30049	NUM
bam-7218	980	6	-	-	PUNCT
bam-7218	980	7	3	3	NUM
bam-7218	980	8	.	.	PUNCT
bam-7218	981	1	p.15	p.15	ADP
bam-7218	981	2	physiopathological	physiopathological	ADJ
bam-7218	981	3	characterization	characterization	NOUN
bam-7218	981	4	of	of	ADP
bam-7218	981	5	the	the	DET
bam-7218	981	6	role	role	NOUN
bam-7218	981	7	of	of	ADP
bam-7218	981	8	mcub	mcub	NOUN
bam-7218	981	9	in	in	ADP
bam-7218	981	10	skeletal	skeletal	ADJ
bam-7218	981	11	muscle	muscle	NOUN
bam-7218	981	12	regeneration	regeneration	NOUN
bam-7218	981	13	simona	simona	NOUN
bam-7218	981	14	feno	feno	NOUN
bam-7218	981	15	(	(	PUNCT
bam-7218	981	16	a	a	X
bam-7218	981	17	)	)	PUNCT
bam-7218	981	18	,	,	PUNCT
bam-7218	981	19	fabio	fabio	VERB
bam-7218	981	20	munari	munari	PROPN
bam-7218	981	21	(	(	PUNCT
bam-7218	981	22	a	a	X
bam-7218	981	23	)	)	PUNCT
bam-7218	981	24	,	,	PUNCT
bam-7218	981	25	antonella	antonella	PROPN
bam-7218	981	26	viola	viola	PROPN
bam-7218	981	27	(	(	PUNCT
bam-7218	981	28	a	a	NOUN
bam-7218	981	29	)	)	PUNCT
bam-7218	981	30	,	,	PUNCT
bam-7218	981	31	anna	anna	PROPN
bam-7218	981	32	raffaello	raffaello	PROPN
bam-7218	981	33	(	(	PUNCT
bam-7218	981	34	a	a	NOUN
bam-7218	981	35	)	)	PUNCT
bam-7218	981	36	,	,	PUNCT
bam-7218	981	37	rosario	rosario	PROPN
bam-7218	981	38	rizzuto	rizzuto	PROPN
bam-7218	981	39	(	(	PUNCT
bam-7218	981	40	b	b	NOUN
bam-7218	981	41	)	)	PUNCT
bam-7218	981	42	(	(	PUNCT
bam-7218	981	43	a	a	X
bam-7218	981	44	)	)	PUNCT
bam-7218	981	45	dept	dept	NOUN
bam-7218	981	46	of	of	ADP
bam-7218	981	47	biomedical	biomedical	ADJ
bam-7218	981	48	sciences	sciences	PROPN
bam-7218	981	49	,	,	PUNCT
bam-7218	981	50	university	university	NOUN
bam-7218	981	51	of	of	ADP
bam-7218	981	52	padova	padova	PROPN
bam-7218	981	53	;	;	PUNCT
bam-7218	981	54	(	(	PUNCT
bam-7218	981	55	b	b	X
bam-7218	981	56	)	)	PUNCT
bam-7218	981	57	dept	dept	NOUN
bam-7218	981	58	of	of	ADP
bam-7218	981	59	biomedical	biomedical	ADJ
bam-7218	981	60	sciences	sciences	PROPN
bam-7218	981	61	and	and	CCONJ
bam-7218	981	62	cnr	cnr	PROPN
bam-7218	981	63	neuroscience	neuroscience	PROPN
bam-7218	981	64	institute	institute	PROPN
bam-7218	981	65	,	,	PUNCT
bam-7218	981	66	university	university	PROPN
bam-7218	981	67	of	of	ADP
bam-7218	981	68	padova	padova	PROPN
bam-7218	981	69	,	,	PUNCT
bam-7218	981	70	italy	italy	PROPN
bam-7218	981	71	.	.	PUNCT
bam-7218	982	1	e	e	X
bam-7218	982	2	-	-	NOUN
bam-7218	982	3	mail	mail	NOUN
bam-7218	982	4	:	:	PUNCT
bam-7218	982	5	simona.feno@yahoo.it	simona.feno@yahoo.it	NOUN
bam-7218	982	6	mitochondrial	mitochondrial	ADJ
bam-7218	982	7	calcium	calcium	NOUN
bam-7218	982	8	uptake	uptake	NOUN
bam-7218	982	9	plays	play	VERB
bam-7218	982	10	a	a	DET
bam-7218	982	11	key	key	ADJ
bam-7218	982	12	role	role	NOUN
bam-7218	982	13	in	in	ADP
bam-7218	982	14	modulating	modulate	VERB
bam-7218	982	15	cell	cell	NOUN
bam-7218	982	16	metabolism	metabolism	NOUN
bam-7218	982	17	,	,	PUNCT
bam-7218	982	18	cell	cell	NOUN
bam-7218	982	19	survival	survival	NOUN
bam-7218	982	20	and	and	CCONJ
bam-7218	982	21	other	other	ADJ
bam-7218	982	22	cell	cell	NOUN
bam-7218	982	23	specific	specific	ADJ
bam-7218	982	24	functions	function	NOUN
bam-7218	982	25	.	.	PUNCT
bam-7218	983	1	calcium	calcium	NOUN
bam-7218	983	2	accumulates	accumulate	VERB
bam-7218	983	3	into	into	ADP
bam-7218	983	4	the	the	DET
bam-7218	983	5	mitochondrial	mitochondrial	ADJ
bam-7218	983	6	matrix	matrix	NOUN
bam-7218	983	7	through	through	ADP
bam-7218	983	8	the	the	DET
bam-7218	983	9	mitochondrial	mitochondrial	ADJ
bam-7218	983	10	calcium	calcium	NOUN
bam-7218	983	11	uniporter	uniporter	NOUN
bam-7218	983	12	(	(	PUNCT
bam-7218	983	13	mcu	mcu	NOUN
bam-7218	983	14	)	)	PUNCT
bam-7218	983	15	.	.	PUNCT
bam-7218	984	1	few	few	ADJ
bam-7218	984	2	years	year	NOUN
bam-7218	984	3	ago	ago	ADV
bam-7218	984	4	a	a	DET
bam-7218	984	5	mcu	mcu	PROPN
bam-7218	984	6	homolog	homolog	NOUN
bam-7218	984	7	has	have	AUX
bam-7218	984	8	been	be	AUX
bam-7218	984	9	discovered	discover	VERB
bam-7218	984	10	,	,	PUNCT
bam-7218	984	11	which	which	PRON
bam-7218	984	12	has	have	AUX
bam-7218	984	13	been	be	AUX
bam-7218	984	14	called	call	VERB
bam-7218	984	15	mcub	mcub	NOUN
bam-7218	984	16	.	.	PUNCT
bam-7218	985	1	mcu	mcu	PROPN
bam-7218	985	2	and	and	CCONJ
bam-7218	985	3	mcub	mcub	NOUN
bam-7218	985	4	shares	share	NOUN
bam-7218	985	5	50	50	NUM
bam-7218	985	6	%	%	NOUN
bam-7218	985	7	sequence	sequence	NOUN
bam-7218	985	8	and	and	CCONJ
bam-7218	985	9	structure	structure	NOUN
bam-7218	985	10	similarity	similarity	NOUN
bam-7218	985	11	although	although	SCONJ
bam-7218	985	12	some	some	DET
bam-7218	985	13	conserved	conserve	VERB
bam-7218	985	14	differences	difference	NOUN
bam-7218	985	15	in	in	ADP
bam-7218	985	16	the	the	DET
bam-7218	985	17	primary	primary	ADJ
bam-7218	985	18	sequence	sequence	NOUN
bam-7218	985	19	prevent	prevent	NOUN
bam-7218	985	20	mcub	mcub	NOUN
bam-7218	985	21	from	from	ADP
bam-7218	985	22	forming	form	VERB
bam-7218	985	23	a	a	DET
bam-7218	985	24	ca	ca	NOUN
bam-7218	985	25	2	2	NUM
bam-7218	985	26	+	+	CCONJ
bam-7218	985	27	permeable	permeable	ADJ
bam-7218	985	28	channel	channel	NOUN
bam-7218	985	29	,	,	PUNCT
bam-7218	985	30	thus	thus	ADV
bam-7218	985	31	acting	act	VERB
bam-7218	985	32	as	as	ADP
bam-7218	985	33	a	a	DET
bam-7218	985	34	dominant	dominant	ADJ
bam-7218	985	35	-	-	PUNCT
bam-7218	985	36	negative	negative	ADJ
bam-7218	985	37	subunit	subunit	NOUN
bam-7218	985	38	.	.	PUNCT
bam-7218	986	1	rt	rt	ADJ
bam-7218	986	2	-	-	PUNCT
bam-7218	986	3	pcr	pcr	ADJ
bam-7218	986	4	experiments	experiment	NOUN
bam-7218	986	5	demonstrated	demonstrate	VERB
bam-7218	986	6	that	that	SCONJ
bam-7218	986	7	mcub	mcub	NOUN
bam-7218	986	8	expression	expression	NOUN
bam-7218	986	9	levels	level	NOUN
bam-7218	986	10	dramatically	dramatically	ADV
bam-7218	986	11	increase	increase	VERB
bam-7218	986	12	during	during	ADP
bam-7218	986	13	skeletal	skeletal	ADJ
bam-7218	986	14	muscle	muscle	NOUN
bam-7218	986	15	regeneration	regeneration	NOUN
bam-7218	986	16	after	after	ADP
bam-7218	986	17	cardiotoxin	cardiotoxin	NOUN
bam-7218	986	18	-	-	PUNCT
bam-7218	986	19	induced	induce	VERB
bam-7218	986	20	injury	injury	NOUN
bam-7218	986	21	.	.	PUNCT
bam-7218	987	1	in	in	ADP
bam-7218	987	2	addition	addition	NOUN
bam-7218	987	3	,	,	PUNCT
bam-7218	987	4	high	high	ADJ
bam-7218	987	5	mcub	mcub	NOUN
bam-7218	987	6	expression	expression	NOUN
bam-7218	987	7	levels	level	NOUN
bam-7218	987	8	have	have	AUX
bam-7218	987	9	been	be	AUX
bam-7218	987	10	detected	detect	VERB
bam-7218	987	11	in	in	ADP
bam-7218	987	12	anti	anti	ADJ
bam-7218	987	13	-	-	ADJ
bam-7218	987	14	inflammatory	inflammatory	ADJ
bam-7218	987	15	macrophages	macrophage	NOUN
bam-7218	987	16	(	(	PUNCT
bam-7218	987	17	m2	m2	PROPN
bam-7218	987	18	)	)	PUNCT
bam-7218	987	19	.	.	PUNCT
bam-7218	988	1	the	the	DET
bam-7218	988	2	latter	latter	ADJ
bam-7218	988	3	are	be	AUX
bam-7218	988	4	one	one	NUM
bam-7218	988	5	of	of	ADP
bam-7218	988	6	the	the	DET
bam-7218	988	7	most	most	ADV
bam-7218	988	8	important	important	ADJ
bam-7218	988	9	effectors	effector	NOUN
bam-7218	988	10	of	of	ADP
bam-7218	988	11	the	the	DET
bam-7218	988	12	later	later	ADJ
bam-7218	988	13	stages	stage	NOUN
bam-7218	988	14	of	of	ADP
bam-7218	988	15	tissue	tissue	NOUN
bam-7218	988	16	repair	repair	NOUN
bam-7218	988	17	.	.	PUNCT
bam-7218	989	1	preliminary	preliminary	ADJ
bam-7218	989	2	results	result	NOUN
bam-7218	989	3	demonstrated	demonstrate	VERB
bam-7218	989	4	that	that	SCONJ
bam-7218	989	5	mcub	mcub	NOUN
bam-7218	989	6	has	have	VERB
bam-7218	989	7	a	a	DET
bam-7218	989	8	key	key	ADJ
bam-7218	989	9	role	role	NOUN
bam-7218	989	10	in	in	ADP
bam-7218	989	11	macrophages	macrophage	NOUN
bam-7218	989	12	skewing	skew	VERB
bam-7218	989	13	from	from	ADP
bam-7218	989	14	m1	m1	PROPN
bam-7218	989	15	to	to	ADP
bam-7218	989	16	m2	m2	PROPN
bam-7218	989	17	phenotype	phenotype	NOUN
bam-7218	989	18	.	.	PUNCT
bam-7218	990	1	in	in	ADP
bam-7218	990	2	order	order	NOUN
bam-7218	990	3	to	to	PART
bam-7218	990	4	confirm	confirm	VERB
bam-7218	990	5	our	our	PRON
bam-7218	990	6	hypothesis	hypothesis	NOUN
bam-7218	990	7	,	,	PUNCT
bam-7218	990	8	we	we	PRON
bam-7218	990	9	performed	perform	VERB
bam-7218	990	10	skeletal	skeletal	ADJ
bam-7218	990	11	muscle	muscle	NOUN
bam-7218	990	12	regeneration	regeneration	NOUN
bam-7218	990	13	experiments	experiment	NOUN
bam-7218	990	14	on	on	ADP
bam-7218	990	15	a	a	DET
bam-7218	990	16	mcub	mcub	NOUN
bam-7218	990	17	ko	ko	PROPN
bam-7218	990	18	mouse	mouse	PROPN
bam-7218	990	19	model	model	NOUN
bam-7218	990	20	.	.	PUNCT
bam-7218	991	1	our	our	PRON
bam-7218	991	2	preliminary	preliminary	ADJ
bam-7218	991	3	results	result	NOUN
bam-7218	991	4	demonstrate	demonstrate	VERB
bam-7218	991	5	that	that	SCONJ
bam-7218	991	6	the	the	DET
bam-7218	991	7	lack	lack	NOUN
bam-7218	991	8	of	of	ADP
bam-7218	991	9	mcub	mcub	NOUN
bam-7218	991	10	causes	cause	VERB
bam-7218	991	11	a	a	DET
bam-7218	991	12	delay	delay	NOUN
bam-7218	991	13	in	in	ADP
bam-7218	991	14	skeletal	skeletal	ADJ
bam-7218	991	15	muscle	muscle	NOUN
bam-7218	991	16	regeneration	regeneration	NOUN
bam-7218	991	17	process	process	NOUN
bam-7218	991	18	that	that	PRON
bam-7218	991	19	occurs	occur	VERB
bam-7218	991	20	in	in	ADP
bam-7218	991	21	parallel	parallel	NOUN
bam-7218	991	22	with	with	ADP
bam-7218	991	23	a	a	DET
bam-7218	991	24	reduction	reduction	NOUN
bam-7218	991	25	of	of	ADP
bam-7218	991	26	the	the	DET
bam-7218	991	27	expression	expression	NOUN
bam-7218	991	28	level	level	NOUN
bam-7218	991	29	of	of	ADP
bam-7218	991	30	known	know	VERB
bam-7218	991	31	markers	marker	NOUN
bam-7218	991	32	of	of	ADP
bam-7218	991	33	m2	m2	PROPN
bam-7218	991	34	.	.	PUNCT
bam-7218	992	1	we	we	PRON
bam-7218	992	2	hypothesized	hypothesize	VERB
bam-7218	992	3	that	that	SCONJ
bam-7218	992	4	this	this	PRON
bam-7218	992	5	altered	alter	VERB
bam-7218	992	6	muscular	muscular	ADJ
bam-7218	992	7	phenotype	phenotype	NOUN
bam-7218	992	8	might	might	AUX
bam-7218	992	9	be	be	AUX
bam-7218	992	10	due	due	ADJ
bam-7218	992	11	to	to	ADP
bam-7218	992	12	an	an	DET
bam-7218	992	13	mailto:esterpasquale@hotmail.it	mailto:esterpasquale@hotmail.it	NOUN
bam-7218	992	14	mailto:simona.feno@yahoo.it	mailto:simona.feno@yahoo.it	PROPN
bam-7218	992	15	14	14	NUM
bam-7218	992	16	th	th	NOUN
bam-7218	992	17	iiim	iiim	NOUN
bam-7218	992	18	meeting	meeting	NOUN
bam-7218	992	19	,	,	PUNCT
bam-7218	992	20	assisi	assisi	PROPN
bam-7218	992	21	,	,	PUNCT
bam-7218	992	22	italy	italy	PROPN
bam-7218	992	23	october	october	PROPN
bam-7218	992	24	12	12	NUM
bam-7218	992	25	-	-	SYM
bam-7218	992	26	15	15	NUM
bam-7218	992	27	2017	2017	NUM
bam-7218	992	28	eur	eur	PROPN
bam-7218	992	29	j	j	PROPN
bam-7218	992	30	transl	transl	PROPN
bam-7218	992	31	myol	myol	ADV
bam-7218	992	32	27	27	NUM
bam-7218	992	33	(	(	PUNCT
bam-7218	992	34	4	4	NUM
bam-7218	992	35	):	):	SYM
bam-7218	992	36	185	185	NUM
bam-7218	992	37	-	-	SYM
bam-7218	992	38	224	224	NUM
bam-7218	992	39	215	215	NUM
bam-7218	992	40	impairment	impairment	NOUN
bam-7218	992	41	in	in	ADP
bam-7218	992	42	macrophages	macrophage	NOUN
bam-7218	992	43	skewing	skew	VERB
bam-7218	992	44	from	from	ADP
bam-7218	992	45	an	an	DET
bam-7218	992	46	m1	m1	NOUN
bam-7218	992	47	to	to	ADP
bam-7218	992	48	m2	m2	PROPN
bam-7218	992	49	phenotype	phenotype	NOUN
bam-7218	992	50	.	.	PUNCT
bam-7218	993	1	indeed	indeed	ADV
bam-7218	993	2	,	,	PUNCT
bam-7218	993	3	macrophages	macrophage	NOUN
bam-7218	993	4	from	from	ADP
bam-7218	993	5	mcub	mcub	NOUN
bam-7218	993	6	ko	ko	PROPN
bam-7218	993	7	animals	animal	NOUN
bam-7218	993	8	have	have	VERB
bam-7218	993	9	lower	low	ADJ
bam-7218	993	10	phagocytic	phagocytic	ADJ
bam-7218	993	11	capacity	capacity	NOUN
bam-7218	993	12	compared	compare	VERB
bam-7218	993	13	to	to	ADP
bam-7218	993	14	wild	wild	ADJ
bam-7218	993	15	type	type	NOUN
bam-7218	993	16	animals	animal	NOUN
bam-7218	993	17	and	and	CCONJ
bam-7218	993	18	this	this	PRON
bam-7218	993	19	affects	affect	VERB
bam-7218	993	20	skeletal	skeletal	ADJ
bam-7218	993	21	muscle	muscle	NOUN
bam-7218	993	22	regeneration	regeneration	NOUN
bam-7218	993	23	.	.	PUNCT
bam-7218	994	1	these	these	DET
bam-7218	994	2	results	result	NOUN
bam-7218	994	3	are	be	AUX
bam-7218	994	4	in	in	ADP
bam-7218	994	5	line	line	NOUN
bam-7218	994	6	with	with	ADP
bam-7218	994	7	published	publish	VERB
bam-7218	994	8	data	datum	NOUN
bam-7218	994	9	demonstrating	demonstrate	VERB
bam-7218	994	10	that	that	SCONJ
bam-7218	994	11	phagocytic	phagocytic	ADJ
bam-7218	994	12	activity	activity	NOUN
bam-7218	994	13	is	be	AUX
bam-7218	994	14	fundamental	fundamental	ADJ
bam-7218	994	15	for	for	ADP
bam-7218	994	16	m2	m2	PROPN
bam-7218	994	17	polarization	polarization	NOUN
bam-7218	994	18	.	.	PUNCT
bam-7218	995	1	p.16	p.16	PRON
bam-7218	995	2	migf-1	migf-1	NUM
bam-7218	995	3	over	over	ADP
bam-7218	995	4	-	-	PUNCT
bam-7218	995	5	expression	expression	NOUN
bam-7218	995	6	ameliorates	ameliorate	NOUN
bam-7218	995	7	dystrophic	dystrophic	ADJ
bam-7218	995	8	muscle	muscle	NOUN
bam-7218	995	9	niche	niche	NOUN
bam-7218	995	10	improving	improve	VERB
bam-7218	995	11	the	the	DET
bam-7218	995	12	efficacy	efficacy	NOUN
bam-7218	995	13	of	of	ADP
bam-7218	995	14	dmd	dmd	NOUN
bam-7218	995	15	therapies	therapy	NOUN
bam-7218	995	16	in	in	ADP
bam-7218	995	17	mdx	mdx	PROPN
bam-7218	995	18	mice	mice	PROPN
bam-7218	995	19	laura	laura	PROPN
bam-7218	995	20	forcina	forcina	VERB
bam-7218	995	21	(	(	PUNCT
bam-7218	995	22	a	a	X
bam-7218	995	23	)	)	PUNCT
bam-7218	995	24	,	,	PUNCT
bam-7218	995	25	laura	laura	NOUN
bam-7218	995	26	pelosi	pelosi	PROPN
bam-7218	995	27	(	(	PUNCT
bam-7218	995	28	a	a	NOUN
bam-7218	995	29	)	)	PUNCT
bam-7218	995	30	,	,	PUNCT
bam-7218	995	31	carmine	carmine	NOUN
bam-7218	995	32	nicoletti	nicoletti	NOUN
bam-7218	995	33	(	(	PUNCT
bam-7218	995	34	a	a	NOUN
bam-7218	995	35	)	)	PUNCT
bam-7218	995	36	,	,	PUNCT
bam-7218	995	37	carmen	carmen	PROPN
bam-7218	995	38	miano	miano	PROPN
bam-7218	995	39	(	(	PUNCT
bam-7218	995	40	a	a	X
bam-7218	995	41	)	)	PUNCT
bam-7218	995	42	,	,	PUNCT
bam-7218	995	43	antonio	antonio	PROPN
bam-7218	995	44	musarò	musarò	NOUN
bam-7218	995	45	(	(	PUNCT
bam-7218	995	46	a	a	DET
bam-7218	995	47	,	,	PUNCT
bam-7218	995	48	b	b	NOUN
bam-7218	995	49	)	)	PUNCT
bam-7218	995	50	(	(	PUNCT
bam-7218	995	51	a	a	PRON
bam-7218	995	52	)	)	PUNCT
bam-7218	995	53	institute	institute	PROPN
bam-7218	995	54	pasteur	pasteur	PROPN
bam-7218	995	55	cenci	cenci	PROPN
bam-7218	995	56	-	-	PUNCT
bam-7218	995	57	bolognetti	bolognetti	PROPN
bam-7218	995	58	dahfmo	dahfmo	NOUN
bam-7218	995	59	-	-	PUNCT
bam-7218	995	60	unit	unit	NOUN
bam-7218	995	61	of	of	ADP
bam-7218	995	62	histology	histology	NOUN
bam-7218	995	63	and	and	CCONJ
bam-7218	995	64	medical	medical	ADJ
bam-7218	995	65	embryology	embryology	NOUN
bam-7218	995	66	,	,	PUNCT
bam-7218	995	67	iim	iim	PROPN
bam-7218	995	68	,	,	PUNCT
bam-7218	995	69	sapienza	sapienza	PROPN
bam-7218	995	70	university	university	PROPN
bam-7218	995	71	of	of	ADP
bam-7218	995	72	rome	rome	PROPN
bam-7218	995	73	;	;	PUNCT
bam-7218	995	74	(	(	PUNCT
bam-7218	995	75	b	b	X
bam-7218	995	76	)	)	PUNCT
bam-7218	995	77	center	center	NOUN
bam-7218	995	78	for	for	ADP
bam-7218	995	79	life	life	NOUN
bam-7218	995	80	nano	nano	NOUN
bam-7218	995	81	science@sapienza	science@sapienza	PUNCT
bam-7218	995	82	istituto	istituto	X
bam-7218	995	83	italiano	italiano	PROPN
bam-7218	995	84	di	di	PROPN
bam-7218	995	85	tecnologia	tecnologia	PROPN
bam-7218	995	86	rome	rome	PROPN
bam-7218	995	87	,	,	PUNCT
bam-7218	995	88	italy	italy	PROPN
bam-7218	995	89	.	.	PUNCT
bam-7218	996	1	e	e	X
bam-7218	996	2	-	-	NOUN
bam-7218	996	3	mail	mail	NOUN
bam-7218	996	4	:	:	PUNCT
bam-7218	996	5	laura.forcina@uniroma1.it	laura.forcina@uniroma1.it	NOUN
bam-7218	996	6	duchenne	duchenne	VERB
bam-7218	996	7	muscular	muscular	ADJ
bam-7218	996	8	dystrophy	dystrophy	NOUN
bam-7218	996	9	(	(	PUNCT
bam-7218	996	10	dmd	dmd	NOUN
bam-7218	996	11	)	)	PUNCT
bam-7218	996	12	is	be	AUX
bam-7218	996	13	a	a	DET
bam-7218	996	14	pathological	pathological	ADJ
bam-7218	996	15	condition	condition	NOUN
bam-7218	996	16	caused	cause	VERB
bam-7218	996	17	by	by	ADP
bam-7218	996	18	the	the	DET
bam-7218	996	19	absence	absence	NOUN
bam-7218	996	20	of	of	ADP
bam-7218	996	21	a	a	DET
bam-7218	996	22	functional	functional	ADJ
bam-7218	996	23	dystrophin	dystrophin	ADJ
bam-7218	996	24	protein	protein	NOUN
bam-7218	996	25	.	.	PUNCT
bam-7218	997	1	to	to	ADP
bam-7218	997	2	date	date	NOUN
bam-7218	997	3	,	,	PUNCT
bam-7218	997	4	there	there	PRON
bam-7218	997	5	is	be	VERB
bam-7218	997	6	no	no	DET
bam-7218	997	7	effective	effective	ADJ
bam-7218	997	8	therapy	therapy	NOUN
bam-7218	997	9	for	for	ADP
bam-7218	997	10	dmd	dmd	NOUN
bam-7218	997	11	;	;	PUNCT
bam-7218	997	12	however	however	ADV
bam-7218	997	13	,	,	PUNCT
bam-7218	997	14	alternative	alternative	ADJ
bam-7218	997	15	therapeutic	therapeutic	ADJ
bam-7218	997	16	approaches	approach	NOUN
bam-7218	997	17	have	have	AUX
bam-7218	997	18	been	be	AUX
bam-7218	997	19	attempted	attempt	VERB
bam-7218	997	20	.	.	PUNCT
bam-7218	998	1	cell	cell	NOUN
bam-7218	998	2	-	-	PUNCT
bam-7218	998	3	based	base	VERB
bam-7218	998	4	therapies	therapy	NOUN
bam-7218	998	5	are	be	AUX
bam-7218	998	6	promising	promise	VERB
bam-7218	998	7	methods	method	NOUN
bam-7218	998	8	for	for	ADP
bam-7218	998	9	treating	treat	VERB
bam-7218	998	10	dmd	dmd	NOUN
bam-7218	998	11	but	but	CCONJ
bam-7218	998	12	stalled	stall	VERB
bam-7218	998	13	by	by	ADP
bam-7218	998	14	a	a	DET
bam-7218	998	15	limited	limited	ADJ
bam-7218	998	16	impact	impact	NOUN
bam-7218	998	17	of	of	ADP
bam-7218	998	18	transplanted	transplanted	ADJ
bam-7218	998	19	stem	stem	NOUN
bam-7218	998	20	cells	cell	NOUN
bam-7218	998	21	on	on	ADP
bam-7218	998	22	the	the	DET
bam-7218	998	23	long	long	ADJ
bam-7218	998	24	-	-	PUNCT
bam-7218	998	25	term	term	NOUN
bam-7218	998	26	muscle	muscle	NOUN
bam-7218	998	27	cell	cell	NOUN
bam-7218	998	28	replacement	replacement	NOUN
bam-7218	998	29	.	.	PUNCT
bam-7218	999	1	gene	gene	NOUN
bam-7218	999	2	therapy	therapy	NOUN
bam-7218	999	3	,	,	PUNCT
bam-7218	999	4	including	include	VERB
bam-7218	999	5	exonskipping	exonskippe	VERB
bam-7218	999	6	,	,	PUNCT
bam-7218	999	7	gained	gain	VERB
bam-7218	999	8	interest	interest	NOUN
bam-7218	999	9	because	because	SCONJ
bam-7218	999	10	of	of	ADP
bam-7218	999	11	optimistic	optimistic	ADJ
bam-7218	999	12	results	result	NOUN
bam-7218	999	13	in	in	ADP
bam-7218	999	14	clinical	clinical	ADJ
bam-7218	999	15	trials	trial	NOUN
bam-7218	999	16	but	but	CCONJ
bam-7218	999	17	antisense	antisense	NOUN
bam-7218	999	18	oligonucleotides	oligonucleotide	NOUN
bam-7218	999	19	(	(	PUNCT
bam-7218	999	20	ao	ao	PROPN
bam-7218	999	21	)	)	PUNCT
bam-7218	999	22	needs	need	VERB
bam-7218	999	23	to	to	PART
bam-7218	999	24	be	be	AUX
bam-7218	999	25	chronically	chronically	ADV
bam-7218	999	26	injected	inject	VERB
bam-7218	999	27	to	to	PART
bam-7218	999	28	maintain	maintain	VERB
bam-7218	999	29	a	a	DET
bam-7218	999	30	clinical	clinical	ADJ
bam-7218	999	31	efficacy	efficacy	NOUN
bam-7218	999	32	.	.	PUNCT
bam-7218	1000	1	our	our	PRON
bam-7218	1000	2	working	work	VERB
bam-7218	1000	3	hypothesis	hypothesis	NOUN
bam-7218	1000	4	is	be	AUX
bam-7218	1000	5	that	that	SCONJ
bam-7218	1000	6	the	the	DET
bam-7218	1000	7	hostile	hostile	ADJ
bam-7218	1000	8	dystrophic	dystrophic	ADJ
bam-7218	1000	9	microenvironment	microenvironment	NOUN
bam-7218	1000	10	might	might	AUX
bam-7218	1000	11	interfere	interfere	VERB
bam-7218	1000	12	with	with	ADP
bam-7218	1000	13	and	and	CCONJ
bam-7218	1000	14	limit	limit	VERB
bam-7218	1000	15	the	the	DET
bam-7218	1000	16	efficacy	efficacy	NOUN
bam-7218	1000	17	of	of	ADP
bam-7218	1000	18	dmd	dmd	NOUN
bam-7218	1000	19	therapies	therapy	NOUN
bam-7218	1000	20	.	.	PUNCT
bam-7218	1001	1	a	a	DET
bam-7218	1001	2	potential	potential	ADJ
bam-7218	1001	3	candidate	candidate	NOUN
bam-7218	1001	4	that	that	PRON
bam-7218	1001	5	contributes	contribute	VERB
bam-7218	1001	6	to	to	PART
bam-7218	1001	7	sustain	sustain	VERB
bam-7218	1001	8	a	a	DET
bam-7218	1001	9	more	more	ADV
bam-7218	1001	10	hospitable	hospitable	ADJ
bam-7218	1001	11	microenvironment	microenvironment	NOUN
bam-7218	1001	12	in	in	ADP
bam-7218	1001	13	dystrophic	dystrophic	ADJ
bam-7218	1001	14	muscle	muscle	NOUN
bam-7218	1001	15	is	be	AUX
bam-7218	1001	16	the	the	DET
bam-7218	1001	17	insulinlike	insulinlike	NOUN
bam-7218	1001	18	growth	growth	NOUN
bam-7218	1001	19	factor-1	factor-1	PROPN
bam-7218	1001	20	(	(	PUNCT
bam-7218	1001	21	igf-1	igf-1	NOUN
bam-7218	1001	22	)	)	PUNCT
bam-7218	1001	23	.	.	PUNCT
bam-7218	1002	1	we	we	PRON
bam-7218	1002	2	previously	previously	ADV
bam-7218	1002	3	demonstrated	demonstrate	VERB
bam-7218	1002	4	that	that	SCONJ
bam-7218	1002	5	local	local	ADJ
bam-7218	1002	6	igf-1	igf-1	NOUN
bam-7218	1002	7	over	over	ADP
bam-7218	1002	8	-	-	PUNCT
bam-7218	1002	9	expression	expression	NOUN
bam-7218	1002	10	plays	play	VERB
bam-7218	1002	11	a	a	DET
bam-7218	1002	12	critical	critical	ADJ
bam-7218	1002	13	role	role	NOUN
bam-7218	1002	14	in	in	ADP
bam-7218	1002	15	muscle	muscle	NOUN
bam-7218	1002	16	regeneration	regeneration	NOUN
bam-7218	1002	17	modulating	modulate	VERB
bam-7218	1002	18	musclespecific	musclespecific	ADJ
bam-7218	1002	19	genes	gene	NOUN
bam-7218	1002	20	associated	associate	VERB
bam-7218	1002	21	with	with	ADP
bam-7218	1002	22	maturation	maturation	NOUN
bam-7218	1002	23	of	of	ADP
bam-7218	1002	24	regenerating	regenerate	VERB
bam-7218	1002	25	fibers	fiber	NOUN
bam-7218	1002	26	.	.	PUNCT
bam-7218	1003	1	thus	thus	ADV
bam-7218	1003	2	,	,	PUNCT
bam-7218	1003	3	migf-1	migf-1	NUM
bam-7218	1003	4	over	over	ADP
bam-7218	1003	5	-	-	PUNCT
bam-7218	1003	6	expression	expression	NOUN
bam-7218	1003	7	in	in	ADP
bam-7218	1003	8	dystrophic	dystrophic	ADJ
bam-7218	1003	9	context	context	NOUN
bam-7218	1003	10	could	could	AUX
bam-7218	1003	11	be	be	AUX
bam-7218	1003	12	useful	useful	ADJ
bam-7218	1003	13	for	for	ADP
bam-7218	1003	14	cell	cell	NOUN
bam-7218	1003	15	-	-	PUNCT
bam-7218	1003	16	based	base	VERB
bam-7218	1003	17	therapy	therapy	NOUN
bam-7218	1003	18	,	,	PUNCT
bam-7218	1003	19	sustaining	sustain	VERB
bam-7218	1003	20	resident	resident	NOUN
bam-7218	1003	21	and	and	CCONJ
bam-7218	1003	22	transplanted	transplanted	ADJ
bam-7218	1003	23	stem	stem	NOUN
bam-7218	1003	24	cells	cell	NOUN
bam-7218	1003	25	survival	survival	NOUN
bam-7218	1003	26	and	and	CCONJ
bam-7218	1003	27	could	could	AUX
bam-7218	1003	28	improve	improve	VERB
bam-7218	1003	29	the	the	DET
bam-7218	1003	30	efficacy	efficacy	NOUN
bam-7218	1003	31	of	of	ADP
bam-7218	1003	32	the	the	DET
bam-7218	1003	33	exon	exon	ADJ
bam-7218	1003	34	skipping	skip	VERB
bam-7218	1003	35	-	-	PUNCT
bam-7218	1003	36	mediated	mediate	VERB
bam-7218	1003	37	approach	approach	NOUN
bam-7218	1003	38	trough	trough	ADP
bam-7218	1003	39	the	the	DET
bam-7218	1003	40	stabilization	stabilization	NOUN
bam-7218	1003	41	of	of	ADP
bam-7218	1003	42	the	the	DET
bam-7218	1003	43	differentiated	differentiated	ADJ
bam-7218	1003	44	phenotype	phenotype	NOUN
bam-7218	1003	45	in	in	ADP
bam-7218	1003	46	mdx	mdx	NOUN
bam-7218	1003	47	muscle	muscle	NOUN
bam-7218	1003	48	.	.	PUNCT
bam-7218	1004	1	in	in	ADP
bam-7218	1004	2	this	this	DET
bam-7218	1004	3	work	work	NOUN
bam-7218	1004	4	we	we	PRON
bam-7218	1004	5	show	show	VERB
bam-7218	1004	6	how	how	SCONJ
bam-7218	1004	7	migf-1	migf-1	NUM
bam-7218	1004	8	over	over	NOUN
bam-7218	1004	9	-	-	PUNCT
bam-7218	1004	10	expression	expression	NOUN
bam-7218	1004	11	in	in	ADP
bam-7218	1004	12	mdx	mdx	NOUN
bam-7218	1004	13	mice	mouse	NOUN
bam-7218	1004	14	is	be	AUX
bam-7218	1004	15	able	able	ADJ
bam-7218	1004	16	to	to	PART
bam-7218	1004	17	modulate	modulate	VERB
bam-7218	1004	18	pathological	pathological	ADJ
bam-7218	1004	19	mechanisms	mechanism	NOUN
bam-7218	1004	20	affecting	affect	VERB
bam-7218	1004	21	muscle	muscle	NOUN
bam-7218	1004	22	niche	niche	NOUN
bam-7218	1004	23	.	.	PUNCT
bam-7218	1005	1	moreover	moreover	ADV
bam-7218	1005	2	,	,	PUNCT
bam-7218	1005	3	we	we	PRON
bam-7218	1005	4	analysed	analyse	VERB
bam-7218	1005	5	the	the	DET
bam-7218	1005	6	impact	impact	NOUN
bam-7218	1005	7	of	of	ADP
bam-7218	1005	8	the	the	DET
bam-7218	1005	9	modulation	modulation	NOUN
bam-7218	1005	10	of	of	ADP
bam-7218	1005	11	dystrophic	dystrophic	ADJ
bam-7218	1005	12	environment	environment	NOUN
bam-7218	1005	13	by	by	ADP
bam-7218	1005	14	migf-1	migf-1	NUM
bam-7218	1005	15	on	on	ADP
bam-7218	1005	16	both	both	DET
bam-7218	1005	17	stem	stem	NOUN
bam-7218	1005	18	cell	cell	NOUN
bam-7218	1005	19	therapy	therapy	NOUN
bam-7218	1005	20	,	,	PUNCT
bam-7218	1005	21	based	base	VERB
bam-7218	1005	22	on	on	ADP
bam-7218	1005	23	mesoangioblasts	mesoangioblast	NOUN
bam-7218	1005	24	transplantation	transplantation	NOUN
bam-7218	1005	25	,	,	PUNCT
bam-7218	1005	26	and	and	CCONJ
bam-7218	1005	27	gene	gene	NOUN
bam-7218	1005	28	therapy	therapy	NOUN
bam-7218	1005	29	performed	perform	VERB
bam-7218	1005	30	using	use	VERB
bam-7218	1005	31	pmo	pmo	PROPN
bam-7218	1005	32	-	-	PUNCT
bam-7218	1005	33	pip6a	pip6a	PROPN
bam-7218	1005	34	,	,	PUNCT
bam-7218	1005	35	a	a	DET
bam-7218	1005	36	new	new	ADJ
bam-7218	1005	37	generation	generation	NOUN
bam-7218	1005	38	pmobased	pmobase	VERB
bam-7218	1005	39	ao	ao	NOUN
bam-7218	1005	40	conjugated	conjugate	VERB
bam-7218	1005	41	to	to	ADP
bam-7218	1005	42	the	the	DET
bam-7218	1005	43	pip6a	pip6a	PROPN
bam-7218	1005	44	peptide	peptide	NOUN
bam-7218	1005	45	enhancing	enhance	VERB
bam-7218	1005	46	the	the	DET
bam-7218	1005	47	delivery	delivery	NOUN
bam-7218	1005	48	in	in	ADP
bam-7218	1005	49	mdx	mdx	NOUN
bam-7218	1005	50	mice	mouse	NOUN
bam-7218	1005	51	.	.	PUNCT
bam-7218	1006	1	p.17	p.17	AUX
bam-7218	1006	2	the	the	DET
bam-7218	1006	3	hdac	hdac	PROPN
bam-7218	1006	4	inhibitor	inhibitor	NOUN
bam-7218	1006	5	givinostat	givinostat	PROPN
bam-7218	1006	6	counters	counter	VERB
bam-7218	1006	7	the	the	DET
bam-7218	1006	8	atrophy	atrophy	NOUN
bam-7218	1006	9	program	program	NOUN
bam-7218	1006	10	induced	induce	VERB
bam-7218	1006	11	by	by	ADP
bam-7218	1006	12	tnf-	tnf-	PROPN
bam-7218	1006	13	in	in	ADP
bam-7218	1006	14	human	human	ADJ
bam-7218	1006	15	skeletal	skeletal	ADJ
bam-7218	1006	16	myotubes	myotube	NOUN
bam-7218	1006	17	monica	monica	PROPN
bam-7218	1006	18	forino	forino	PROPN
bam-7218	1006	19	,	,	PUNCT
bam-7218	1006	20	julie	julie	PROPN
bam-7218	1006	21	de	de	PROPN
bam-7218	1006	22	santis	santis	PROPN
bam-7218	1006	23	,	,	PUNCT
bam-7218	1006	24	christian	christian	PROPN
bam-7218	1006	25	steikuhler	steikuhler	NOUN
bam-7218	1006	26	,	,	PUNCT
bam-7218	1006	27	gianluca	gianluca	PROPN
bam-7218	1006	28	caprini	caprini	PROPN
bam-7218	1006	29	,	,	PUNCT
bam-7218	1006	30	gianluca	gianluca	PROPN
bam-7218	1006	31	fossati	fossati	PROPN
bam-7218	1006	32	italfarmaco	italfarmaco	PROPN
bam-7218	1006	33	spa	spa	PROPN
bam-7218	1006	34	drug	drug	PROPN
bam-7218	1006	35	discovery	discovery	PROPN
bam-7218	1006	36	dept	dept	PROPN
bam-7218	1006	37	,	,	PUNCT
bam-7218	1006	38	italy	italy	PROPN
bam-7218	1006	39	.	.	PUNCT
bam-7218	1007	1	email	email	NOUN
bam-7218	1007	2	:	:	PUNCT
bam-7218	1007	3	m.forino@italfarmaco.com	m.forino@italfarmaco.com	X
bam-7218	1007	4	histone	histone	PROPN
bam-7218	1007	5	deacetylase	deacetylase	PROPN
bam-7218	1007	6	(	(	PUNCT
bam-7218	1007	7	hdac	hdac	PROPN
bam-7218	1007	8	)	)	PUNCT
bam-7218	1007	9	and	and	CCONJ
bam-7218	1007	10	histone	histone	NOUN
bam-7218	1007	11	acetyltransferase	acetyltransferase	NOUN
bam-7218	1007	12	(	(	PUNCT
bam-7218	1007	13	hat	hat	NOUN
bam-7218	1007	14	)	)	PUNCT
bam-7218	1007	15	catalyse	catalyse	VERB
bam-7218	1007	16	the	the	DET
bam-7218	1007	17	reactions	reaction	NOUN
bam-7218	1007	18	that	that	PRON
bam-7218	1007	19	maintain	maintain	VERB
bam-7218	1007	20	the	the	DET
bam-7218	1007	21	homeostatic	homeostatic	ADJ
bam-7218	1007	22	level	level	NOUN
bam-7218	1007	23	of	of	ADP
bam-7218	1007	24	lysine	lysine	NOUN
bam-7218	1007	25	side	side	NOUN
bam-7218	1007	26	chain	chain	NOUN
bam-7218	1007	27	acetylation	acetylation	NOUN
bam-7218	1007	28	in	in	ADP
bam-7218	1007	29	thousands	thousand	NOUN
bam-7218	1007	30	of	of	ADP
bam-7218	1007	31	cellular	cellular	ADJ
bam-7218	1007	32	proteins	protein	NOUN
bam-7218	1007	33	.	.	PUNCT
bam-7218	1008	1	in	in	ADP
bam-7218	1008	2	muscle	muscle	NOUN
bam-7218	1008	3	cells	cell	NOUN
bam-7218	1008	4	,	,	PUNCT
bam-7218	1008	5	alteration	alteration	NOUN
bam-7218	1008	6	of	of	ADP
bam-7218	1008	7	this	this	DET
bam-7218	1008	8	equilibrium	equilibrium	NOUN
bam-7218	1008	9	is	be	AUX
bam-7218	1008	10	found	find	VERB
bam-7218	1008	11	in	in	ADP
bam-7218	1008	12	a	a	DET
bam-7218	1008	13	variety	variety	NOUN
bam-7218	1008	14	of	of	ADP
bam-7218	1008	15	pathological	pathological	ADJ
bam-7218	1008	16	conditions	condition	NOUN
bam-7218	1008	17	characterized	characterize	VERB
bam-7218	1008	18	by	by	ADP
bam-7218	1008	19	progressive	progressive	ADJ
bam-7218	1008	20	degeneration	degeneration	NOUN
bam-7218	1008	21	and	and	CCONJ
bam-7218	1008	22	atrophy	atrophy	NOUN
bam-7218	1008	23	.	.	PUNCT
bam-7218	1009	1	muscle	muscle	NOUN
bam-7218	1009	2	atrophy	atrophy	NOUN
bam-7218	1009	3	may	may	AUX
bam-7218	1009	4	occur	occur	VERB
bam-7218	1009	5	as	as	ADP
bam-7218	1009	6	a	a	DET
bam-7218	1009	7	consequence	consequence	NOUN
bam-7218	1009	8	of	of	ADP
bam-7218	1009	9	genetic	genetic	ADJ
bam-7218	1009	10	diseases	disease	NOUN
bam-7218	1009	11	such	such	ADJ
bam-7218	1009	12	as	as	ADP
bam-7218	1009	13	duchenne	duchenne	NOUN
bam-7218	1009	14	muscular	muscular	ADJ
bam-7218	1009	15	dystrophy	dystrophy	NOUN
bam-7218	1009	16	(	(	PUNCT
bam-7218	1009	17	dmd	dmd	NOUN
bam-7218	1009	18	)	)	PUNCT
bam-7218	1009	19	.	.	PUNCT
bam-7218	1010	1	dmd	dmd	PROPN
bam-7218	1010	2	is	be	AUX
bam-7218	1010	3	caused	cause	VERB
bam-7218	1010	4	by	by	ADP
bam-7218	1010	5	mutations	mutation	NOUN
bam-7218	1010	6	in	in	ADP
bam-7218	1010	7	the	the	DET
bam-7218	1010	8	dystrophin	dystrophin	ADJ
bam-7218	1010	9	gene	gene	NOUN
bam-7218	1010	10	that	that	PRON
bam-7218	1010	11	lead	lead	VERB
bam-7218	1010	12	to	to	ADP
bam-7218	1010	13	the	the	DET
bam-7218	1010	14	absence	absence	NOUN
bam-7218	1010	15	of	of	ADP
bam-7218	1010	16	the	the	DET
bam-7218	1010	17	functional	functional	ADJ
bam-7218	1010	18	protein	protein	NOUN
bam-7218	1010	19	,	,	PUNCT
bam-7218	1010	20	myofiber	myofiber	ADJ
bam-7218	1010	21	membrane	membrane	NOUN
bam-7218	1010	22	instability	instability	NOUN
bam-7218	1010	23	and	and	CCONJ
bam-7218	1010	24	damage	damage	NOUN
bam-7218	1010	25	upon	upon	SCONJ
bam-7218	1010	26	contraction	contraction	NOUN
bam-7218	1010	27	.	.	PUNCT
bam-7218	1011	1	consequently	consequently	ADV
bam-7218	1011	2	,	,	PUNCT
bam-7218	1011	3	muscle	muscle	NOUN
bam-7218	1011	4	cells	cell	NOUN
bam-7218	1011	5	release	release	VERB
bam-7218	1011	6	cytoplasmic	cytoplasmic	ADJ
bam-7218	1011	7	components	component	NOUN
bam-7218	1011	8	including	include	VERB
bam-7218	1011	9	the	the	DET
bam-7218	1011	10	so	so	ADV
bam-7218	1011	11	-	-	PUNCT
bam-7218	1011	12	called	call	VERB
bam-7218	1011	13	damage	damage	NOUN
bam-7218	1011	14	associated	associate	VERB
bam-7218	1011	15	molecular	molecular	ADJ
bam-7218	1011	16	patterns	pattern	NOUN
bam-7218	1011	17	(	(	PUNCT
bam-7218	1011	18	damps	damp	NOUN
bam-7218	1011	19	)	)	PUNCT
bam-7218	1011	20	.	.	PUNCT
bam-7218	1012	1	these	these	PRON
bam-7218	1012	2	activate	activate	VERB
bam-7218	1012	3	both	both	CCONJ
bam-7218	1012	4	the	the	DET
bam-7218	1012	5	resident	resident	ADJ
bam-7218	1012	6	immune	immune	ADJ
bam-7218	1012	7	cells	cell	NOUN
bam-7218	1012	8	and	and	CCONJ
bam-7218	1012	9	the	the	DET
bam-7218	1012	10	muscle	muscle	NOUN
bam-7218	1012	11	cells	cell	NOUN
bam-7218	1012	12	thus	thus	ADV
bam-7218	1012	13	generating	generate	VERB
bam-7218	1012	14	an	an	DET
bam-7218	1012	15	inflammatory	inflammatory	ADJ
bam-7218	1012	16	environment	environment	NOUN
bam-7218	1012	17	that	that	PRON
bam-7218	1012	18	progressively	progressively	ADV
bam-7218	1012	19	increases	increase	VERB
bam-7218	1012	20	and	and	CCONJ
bam-7218	1012	21	amplifies	amplify	VERB
bam-7218	1012	22	the	the	DET
bam-7218	1012	23	muscle	muscle	NOUN
bam-7218	1012	24	damage	damage	NOUN
bam-7218	1012	25	.	.	PUNCT
bam-7218	1013	1	nf	nf	X
bam-7218	1013	2	-	-	PUNCT
bam-7218	1013	3	kb	kb	NOUN
bam-7218	1013	4	activation	activation	NOUN
bam-7218	1013	5	is	be	AUX
bam-7218	1013	6	one	one	NUM
bam-7218	1013	7	of	of	ADP
bam-7218	1013	8	the	the	DET
bam-7218	1013	9	downstream	downstream	ADJ
bam-7218	1013	10	effect	effect	NOUN
bam-7218	1013	11	of	of	ADP
bam-7218	1013	12	tlr	tlr	PROPN
bam-7218	1013	13	activation	activation	NOUN
bam-7218	1013	14	through	through	ADP
bam-7218	1013	15	damps	damp	NOUN
bam-7218	1013	16	and	and	CCONJ
bam-7218	1013	17	proinflammatory	proinflammatory	ADJ
bam-7218	1013	18	cytokines	cytokine	NOUN
bam-7218	1013	19	such	such	ADJ
bam-7218	1013	20	as	as	ADP
bam-7218	1013	21	tnfthese	tnfthese	ADJ
bam-7218	1013	22	pathways	pathway	NOUN
bam-7218	1013	23	are	be	AUX
bam-7218	1013	24	subjected	subject	VERB
bam-7218	1013	25	to	to	ADP
bam-7218	1013	26	regulation	regulation	NOUN
bam-7218	1013	27	involving	involve	VERB
bam-7218	1013	28	the	the	DET
bam-7218	1013	29	acetylation	acetylation	NOUN
bam-7218	1013	30	of	of	ADP
bam-7218	1013	31	effector	effector	NOUN
bam-7218	1013	32	molecules	molecule	NOUN
bam-7218	1013	33	.	.	PUNCT
bam-7218	1014	1	hdac	hdac	PROPN
bam-7218	1014	2	inhibitors	inhibitor	NOUN
bam-7218	1014	3	are	be	AUX
bam-7218	1014	4	endowed	endow	VERB
bam-7218	1014	5	with	with	ADP
bam-7218	1014	6	pleiotropic	pleiotropic	ADJ
bam-7218	1014	7	activities	activity	NOUN
bam-7218	1014	8	that	that	PRON
bam-7218	1014	9	influence	influence	VERB
bam-7218	1014	10	the	the	DET
bam-7218	1014	11	biology	biology	NOUN
bam-7218	1014	12	of	of	ADP
bam-7218	1014	13	muscle	muscle	NOUN
bam-7218	1014	14	cells	cell	NOUN
bam-7218	1014	15	at	at	ADP
bam-7218	1014	16	different	different	ADJ
bam-7218	1014	17	levels	level	NOUN
bam-7218	1014	18	.	.	PUNCT
bam-7218	1015	1	givinostat	givinostat	PROPN
bam-7218	1015	2	is	be	AUX
bam-7218	1015	3	a	a	DET
bam-7218	1015	4	pan	pan	ADJ
bam-7218	1015	5	-	-	ADJ
bam-7218	1015	6	hdac	hdac	NOUN
bam-7218	1015	7	inhibitor	inhibitor	NOUN
bam-7218	1015	8	currently	currently	ADV
bam-7218	1015	9	in	in	ADP
bam-7218	1015	10	phase	phase	NOUN
bam-7218	1015	11	iii	iii	NUM
bam-7218	1015	12	clinical	clinical	ADJ
bam-7218	1015	13	trial	trial	NOUN
bam-7218	1015	14	for	for	ADP
bam-7218	1015	15	the	the	DET
bam-7218	1015	16	treatment	treatment	NOUN
bam-7218	1015	17	of	of	ADP
bam-7218	1015	18	dmd	dmd	NOUN
bam-7218	1015	19	.	.	PROPN
bam-7218	1015	20	immunohistochemistry	immunohistochemistry	NOUN
bam-7218	1015	21	analysis	analysis	NOUN
bam-7218	1015	22	of	of	ADP
bam-7218	1015	23	patients	patient	NOUN
bam-7218	1015	24	’	'	PUNCT
bam-7218	1015	25	biopsies	biopsy	NOUN
bam-7218	1015	26	demonstrated	demonstrate	VERB
bam-7218	1015	27	that	that	SCONJ
bam-7218	1015	28	treatment	treatment	NOUN
bam-7218	1015	29	with	with	ADP
bam-7218	1015	30	givinostat	givinostat	NOUN
bam-7218	1015	31	lead	lead	NOUN
bam-7218	1015	32	to	to	ADP
bam-7218	1015	33	a	a	DET
bam-7218	1015	34	reduced	reduced	ADJ
bam-7218	1015	35	inflammation	inflammation	NOUN
bam-7218	1015	36	,	,	PUNCT
bam-7218	1015	37	necrosis	necrosis	NOUN
bam-7218	1015	38	,	,	PUNCT
bam-7218	1015	39	fibrosis	fibrosis	NOUN
bam-7218	1015	40	and	and	CCONJ
bam-7218	1015	41	increase	increase	NOUN
bam-7218	1015	42	of	of	ADP
bam-7218	1015	43	the	the	DET
bam-7218	1015	44	cross	cross	PROPN
bam-7218	1015	45	sectional	sectional	ADJ
bam-7218	1015	46	area	area	NOUN
bam-7218	1015	47	of	of	ADP
bam-7218	1015	48	the	the	DET
bam-7218	1015	49	myofibers	myofiber	NOUN
bam-7218	1015	50	that	that	PRON
bam-7218	1015	51	occupy	occupy	VERB
bam-7218	1015	52	a	a	DET
bam-7218	1015	53	larger	large	ADJ
bam-7218	1015	54	fraction	fraction	NOUN
bam-7218	1015	55	of	of	ADP
bam-7218	1015	56	muscle	muscle	NOUN
bam-7218	1015	57	tissue	tissue	NOUN
bam-7218	1015	58	.	.	PUNCT
bam-7218	1016	1	to	to	PART
bam-7218	1016	2	further	far	ADV
bam-7218	1016	3	characterize	characterize	VERB
bam-7218	1016	4	the	the	DET
bam-7218	1016	5	molecular	molecular	ADJ
bam-7218	1016	6	mechanism	mechanism	NOUN
bam-7218	1016	7	of	of	ADP
bam-7218	1016	8	action	action	NOUN
bam-7218	1016	9	of	of	ADP
bam-7218	1016	10	givinostat	givinostat	NOUN
bam-7218	1016	11	on	on	ADP
bam-7218	1016	12	muscle	muscle	NOUN
bam-7218	1016	13	cells	cell	NOUN
bam-7218	1016	14	induced	induce	VERB
bam-7218	1016	15	atrophy	atrophy	NOUN
bam-7218	1016	16	we	we	PRON
bam-7218	1016	17	used	use	VERB
bam-7218	1016	18	in	in	ADP
bam-7218	1016	19	vitro	vitro	X
bam-7218	1016	20	differentiated	differentiated	ADJ
bam-7218	1016	21	human	human	ADJ
bam-7218	1016	22	skeletal	skeletal	ADJ
bam-7218	1016	23	myotubes	myotube	NOUN
bam-7218	1016	24	stimulated	stimulate	VERB
bam-7218	1016	25	with	with	ADP
bam-7218	1016	26	the	the	DET
bam-7218	1016	27	atrophy	atrophy	NOUN
bam-7218	1016	28	inducer	inducer	NOUN
bam-7218	1016	29	cytokine	cytokine	NOUN
bam-7218	1016	30	tnf-.	tnf-.	X
bam-7218	1016	31	we	we	PRON
bam-7218	1016	32	found	find	VERB
bam-7218	1016	33	that	that	DET
bam-7218	1016	34	givinostat	givinostat	NOUN
bam-7218	1016	35	countered	counter	VERB
bam-7218	1016	36	the	the	DET
bam-7218	1016	37	upregulation	upregulation	NOUN
bam-7218	1016	38	of	of	ADP
bam-7218	1016	39	some	some	DET
bam-7218	1016	40	key	key	ADJ
bam-7218	1016	41	atrogenes	atrogene	NOUN
bam-7218	1016	42	such	such	ADJ
bam-7218	1016	43	as	as	ADP
bam-7218	1016	44	trim63	trim63	NOUN
bam-7218	1016	45	and	and	CCONJ
bam-7218	1016	46	atrogin-1	atrogin-1	NUM
bam-7218	1016	47	induced	induce	VERB
bam-7218	1016	48	by	by	ADP
bam-7218	1016	49	tnf-	tnf-	PROPN
bam-7218	1016	50	activated	activate	VERB
bam-7218	1016	51	the	the	DET
bam-7218	1016	52	expression	expression	NOUN
bam-7218	1016	53	of	of	ADP
bam-7218	1016	54	hdac4	hdac4	NOUN
bam-7218	1016	55	and	and	CCONJ
bam-7218	1016	56	hdac6	hdac6	PROPN
bam-7218	1016	57	,	,	PUNCT
bam-7218	1016	58	both	both	PRON
bam-7218	1016	59	involved	involve	VERB
bam-7218	1016	60	in	in	ADP
bam-7218	1016	61	muscle	muscle	NOUN
bam-7218	1016	62	atrophy	atrophy	NOUN
bam-7218	1016	63	.	.	PUNCT
bam-7218	1017	1	furthermore	furthermore	ADV
bam-7218	1017	2	,	,	PUNCT
bam-7218	1017	3	hdac6	hdac6	PROPN
bam-7218	1017	4	has	have	AUX
bam-7218	1017	5	been	be	AUX
bam-7218	1017	6	recently	recently	ADV
bam-7218	1017	7	described	describe	VERB
bam-7218	1017	8	as	as	ADP
bam-7218	1017	9	an	an	DET
bam-7218	1017	10	atrogene	atrogene	NOUN
bam-7218	1017	11	that	that	PRON
bam-7218	1017	12	interact	interact	VERB
bam-7218	1017	13	with	with	ADP
bam-7218	1017	14	atrogin-1	atrogin-1	NUM
bam-7218	1017	15	multiprotein	multiprotein	ADJ
bam-7218	1017	16	complex	complex	NOUN
bam-7218	1017	17	.	.	PUNCT
bam-7218	1018	1	as	as	SCONJ
bam-7218	1018	2	expected	expect	VERB
bam-7218	1018	3	,	,	PUNCT
bam-7218	1018	4	givinostat	givinostat	PROPN
bam-7218	1018	5	induced	induce	VERB
bam-7218	1018	6	tubulin	tubulin	NOUN
bam-7218	1018	7	hyperacetylation	hyperacetylation	NOUN
bam-7218	1018	8	,	,	PUNCT
bam-7218	1018	9	a	a	DET
bam-7218	1018	10	pharmacodynamic	pharmacodynamic	ADJ
bam-7218	1018	11	marker	marker	NOUN
bam-7218	1018	12	of	of	ADP
bam-7218	1018	13	hdac6	hdac6	NOUN
bam-7218	1018	14	inhibition	inhibition	NOUN
bam-7218	1018	15	.	.	PUNCT
bam-7218	1019	1	since	since	SCONJ
bam-7218	1019	2	givinostat	givinostat	NOUN
bam-7218	1019	3	inhibits	inhibit	VERB
bam-7218	1019	4	hdac4	hdac4	NOUN
bam-7218	1019	5	activity	activity	NOUN
bam-7218	1019	6	,	,	PUNCT
bam-7218	1019	7	both	both	DET
bam-7218	1019	8	enzymes	enzyme	NOUN
bam-7218	1019	9	are	be	AUX
bam-7218	1019	10	dually	dually	ADV
bam-7218	1019	11	inhibited	inhibit	VERB
bam-7218	1019	12	,	,	PUNCT
bam-7218	1019	13	at	at	ADP
bam-7218	1019	14	transcriptional	transcriptional	ADJ
bam-7218	1019	15	and	and	CCONJ
bam-7218	1019	16	functional	functional	ADJ
bam-7218	1019	17	level	level	NOUN
bam-7218	1019	18	.	.	PUNCT
bam-7218	1020	1	in	in	ADP
bam-7218	1020	2	agreement	agreement	NOUN
bam-7218	1020	3	with	with	ADP
bam-7218	1020	4	these	these	DET
bam-7218	1020	5	gene	gene	NOUN
bam-7218	1020	6	modulations	modulation	NOUN
bam-7218	1020	7	,	,	PUNCT
bam-7218	1020	8	we	we	PRON
bam-7218	1020	9	found	find	VERB
bam-7218	1020	10	that	that	DET
bam-7218	1020	11	givinostat	givinostat	NOUN
bam-7218	1020	12	upregulated	upregulate	VERB
bam-7218	1020	13	the	the	DET
bam-7218	1020	14	gene	gene	NOUN
bam-7218	1020	15	expression	expression	NOUN
bam-7218	1020	16	of	of	ADP
bam-7218	1020	17	myosin	myosin	PROPN
bam-7218	1020	18	heavy	heavy	PROPN
bam-7218	1020	19	chain	chain	NOUN
bam-7218	1020	20	i	i	PROPN
bam-7218	1020	21	and	and	CCONJ
bam-7218	1020	22	ii	ii	PROPN
bam-7218	1020	23	that	that	PRON
bam-7218	1020	24	are	be	AUX
bam-7218	1020	25	targeted	target	VERB
bam-7218	1020	26	to	to	PART
bam-7218	1020	27	proteasomal	proteasomal	VERB
bam-7218	1020	28	degradation	degradation	NOUN
bam-7218	1020	29	mailto:laura.forcina@uniroma1.it	mailto:laura.forcina@uniroma1.it	NOUN
bam-7218	1020	30	mailto:m.forino@italfarmaco.com	mailto:m.forino@italfarmaco.com	X
bam-7218	1020	31	14	14	NUM
bam-7218	1020	32	th	th	NOUN
bam-7218	1020	33	iiim	iiim	NOUN
bam-7218	1020	34	meeting	meeting	NOUN
bam-7218	1020	35	,	,	PUNCT
bam-7218	1020	36	assisi	assisi	PROPN
bam-7218	1020	37	,	,	PUNCT
bam-7218	1020	38	italy	italy	PROPN
bam-7218	1020	39	october	october	PROPN
bam-7218	1020	40	12	12	NUM
bam-7218	1020	41	-	-	SYM
bam-7218	1020	42	15	15	NUM
bam-7218	1020	43	2017	2017	NUM
bam-7218	1020	44	eur	eur	PROPN
bam-7218	1020	45	j	j	PROPN
bam-7218	1020	46	transl	transl	PROPN
bam-7218	1020	47	myol	myol	ADV
bam-7218	1020	48	27	27	NUM
bam-7218	1020	49	(	(	PUNCT
bam-7218	1020	50	4	4	NUM
bam-7218	1020	51	):	):	SYM
bam-7218	1020	52	185	185	NUM
bam-7218	1020	53	-	-	SYM
bam-7218	1020	54	224	224	NUM
bam-7218	1020	55	216	216	NUM
bam-7218	1020	56	during	during	ADP
bam-7218	1020	57	atrophy	atrophy	NOUN
bam-7218	1020	58	.	.	PUNCT
bam-7218	1021	1	taken	take	VERB
bam-7218	1021	2	together	together	ADV
bam-7218	1021	3	,	,	PUNCT
bam-7218	1021	4	these	these	DET
bam-7218	1021	5	data	datum	NOUN
bam-7218	1021	6	indicate	indicate	VERB
bam-7218	1021	7	that	that	SCONJ
bam-7218	1021	8	givinostat	givinostat	NOUN
bam-7218	1021	9	counters	counter	VERB
bam-7218	1021	10	the	the	DET
bam-7218	1021	11	atrophy	atrophy	NOUN
bam-7218	1021	12	program	program	NOUN
bam-7218	1021	13	induced	induce	VERB
bam-7218	1021	14	by	by	ADP
bam-7218	1021	15	tnf-	tnf-	NOUN
bam-7218	1021	16	in	in	ADP
bam-7218	1021	17	normal	normal	ADJ
bam-7218	1021	18	skeletal	skeletal	ADJ
bam-7218	1021	19	muscle	muscle	NOUN
bam-7218	1021	20	cells	cell	NOUN
bam-7218	1021	21	and	and	CCONJ
bam-7218	1021	22	suggest	suggest	VERB
bam-7218	1021	23	that	that	SCONJ
bam-7218	1021	24	a	a	DET
bam-7218	1021	25	similar	similar	ADJ
bam-7218	1021	26	mechanism	mechanism	NOUN
bam-7218	1021	27	may	may	AUX
bam-7218	1021	28	take	take	VERB
bam-7218	1021	29	place	place	NOUN
bam-7218	1021	30	in	in	ADP
bam-7218	1021	31	dmd	dmd	NOUN
bam-7218	1021	32	muscle	muscle	NOUN
bam-7218	1021	33	cells	cell	NOUN
bam-7218	1021	34	.	.	PUNCT
bam-7218	1022	1	p.18	p.18	PRON
bam-7218	1022	2	investigating	investigate	VERB
bam-7218	1022	3	the	the	DET
bam-7218	1022	4	cell	cell	NOUN
bam-7218	1022	5	origin	origin	NOUN
bam-7218	1022	6	and	and	CCONJ
bam-7218	1022	7	heterogeneity	heterogeneity	NOUN
bam-7218	1022	8	of	of	ADP
bam-7218	1022	9	embryonal	embryonal	ADJ
bam-7218	1022	10	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-7218	1022	11	claudia	claudia	NOUN
bam-7218	1022	12	fuoco	fuoco	NOUN
bam-7218	1022	13	,	,	PUNCT
bam-7218	1022	14	lucia	lucia	PROPN
bam-7218	1022	15	lisa	lisa	PROPN
bam-7218	1022	16	petrilli	petrilli	PROPN
bam-7218	1022	17	,	,	PUNCT
bam-7218	1022	18	luisa	luisa	PROPN
bam-7218	1022	19	castagnoli	castagnoli	PROPN
bam-7218	1022	20	,	,	PUNCT
bam-7218	1022	21	cesare	cesare	PROPN
bam-7218	1022	22	gargioli	gargioli	PROPN
bam-7218	1022	23	,	,	PUNCT
bam-7218	1022	24	gianni	gianni	PROPN
bam-7218	1022	25	cesareni	cesareni	PROPN
bam-7218	1022	26	dept	dept	PROPN
bam-7218	1022	27	of	of	ADP
bam-7218	1022	28	biology	biology	NOUN
bam-7218	1022	29	,	,	PUNCT
bam-7218	1022	30	rome	rome	PROPN
bam-7218	1022	31	university	university	NOUN
bam-7218	1022	32	tor	tor	PROPN
bam-7218	1022	33	vergata	vergata	PROPN
bam-7218	1022	34	,	,	PUNCT
bam-7218	1022	35	italy	italy	PROPN
bam-7218	1022	36	.	.	PUNCT
bam-7218	1022	37	email	email	NOUN
bam-7218	1022	38	:	:	PUNCT
bam-7218	1022	39	c.fuoco@yahoo.it	c.fuoco@yahoo.it	NOUN
bam-7218	1022	40	with	with	ADP
bam-7218	1022	41	an	an	DET
bam-7218	1022	42	incidence	incidence	NOUN
bam-7218	1022	43	of	of	ADP
bam-7218	1022	44	4.5	4.5	NUM
bam-7218	1022	45	cases	case	NOUN
bam-7218	1022	46	per	per	ADP
bam-7218	1022	47	million	million	NUM
bam-7218	1022	48	adolescents	adolescent	NOUN
bam-7218	1022	49	,	,	PUNCT
bam-7218	1022	50	the	the	DET
bam-7218	1022	51	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-7218	1022	52	(	(	PUNCT
bam-7218	1022	53	rms	rm	NOUN
bam-7218	1022	54	)	)	PUNCT
bam-7218	1022	55	is	be	AUX
bam-7218	1022	56	the	the	DET
bam-7218	1022	57	most	most	ADV
bam-7218	1022	58	common	common	ADJ
bam-7218	1022	59	type	type	NOUN
bam-7218	1022	60	of	of	ADP
bam-7218	1022	61	soft	soft	ADJ
bam-7218	1022	62	tissue	tissue	NOUN
bam-7218	1022	63	sarcoma	sarcoma	NOUN
bam-7218	1022	64	.	.	PUNCT
bam-7218	1023	1	it	it	PRON
bam-7218	1023	2	develops	develop	VERB
bam-7218	1023	3	in	in	ADP
bam-7218	1023	4	different	different	ADJ
bam-7218	1023	5	tissues	tissue	NOUN
bam-7218	1023	6	,	,	PUNCT
bam-7218	1023	7	most	most	ADV
bam-7218	1023	8	commonly	commonly	ADV
bam-7218	1023	9	in	in	ADP
bam-7218	1023	10	the	the	DET
bam-7218	1023	11	head	head	NOUN
bam-7218	1023	12	and	and	CCONJ
bam-7218	1023	13	neck	neck	NOUN
bam-7218	1023	14	,	,	PUNCT
bam-7218	1023	15	in	in	ADP
bam-7218	1023	16	the	the	DET
bam-7218	1023	17	extremities	extremity	NOUN
bam-7218	1023	18	and	and	CCONJ
bam-7218	1023	19	in	in	ADP
bam-7218	1023	20	the	the	DET
bam-7218	1023	21	genitourinary	genitourinary	ADJ
bam-7218	1023	22	tract	tract	NOUN
bam-7218	1023	23	.	.	PUNCT
bam-7218	1024	1	according	accord	VERB
bam-7218	1024	2	to	to	ADP
bam-7218	1024	3	its	its	PRON
bam-7218	1024	4	histological	histological	ADJ
bam-7218	1024	5	and	and	CCONJ
bam-7218	1024	6	pathological	pathological	ADJ
bam-7218	1024	7	characteristics	characteristic	NOUN
bam-7218	1024	8	,	,	PUNCT
bam-7218	1024	9	rms	rm	NOUN
bam-7218	1024	10	can	can	AUX
bam-7218	1024	11	be	be	AUX
bam-7218	1024	12	classified	classify	VERB
bam-7218	1024	13	in	in	ADP
bam-7218	1024	14	two	two	NUM
bam-7218	1024	15	major	major	ADJ
bam-7218	1024	16	subtypes	subtype	NOUN
bam-7218	1024	17	,	,	PUNCT
bam-7218	1024	18	embryonal	embryonal	ADJ
bam-7218	1024	19	(	(	PUNCT
bam-7218	1024	20	erms	erm	NOUN
bam-7218	1024	21	)	)	PUNCT
bam-7218	1024	22	and	and	CCONJ
bam-7218	1024	23	alveolar	alveolar	ADJ
bam-7218	1024	24	(	(	PUNCT
bam-7218	1024	25	arms	arm	NOUN
bam-7218	1024	26	)	)	PUNCT
bam-7218	1024	27	,	,	PUNCT
bam-7218	1024	28	which	which	PRON
bam-7218	1024	29	seem	seem	VERB
bam-7218	1024	30	to	to	PART
bam-7218	1024	31	share	share	VERB
bam-7218	1024	32	the	the	DET
bam-7218	1024	33	same	same	ADJ
bam-7218	1024	34	initiating	initiate	VERB
bam-7218	1024	35	cell	cell	NOUN
bam-7218	1024	36	type(s	type(s	NOUN
bam-7218	1024	37	)	)	PUNCT
bam-7218	1024	38	,	,	PUNCT
bam-7218	1024	39	even	even	ADV
bam-7218	1024	40	if	if	SCONJ
bam-7218	1024	41	this	this	DET
bam-7218	1024	42	point	point	NOUN
bam-7218	1024	43	is	be	AUX
bam-7218	1024	44	still	still	ADV
bam-7218	1024	45	debated	debate	VERB
bam-7218	1024	46	.	.	PUNCT
bam-7218	1025	1	in	in	ADP
bam-7218	1025	2	fact	fact	NOUN
bam-7218	1025	3	,	,	PUNCT
bam-7218	1025	4	some	some	DET
bam-7218	1025	5	evidence	evidence	NOUN
bam-7218	1025	6	supports	support	VERB
bam-7218	1025	7	the	the	DET
bam-7218	1025	8	notion	notion	NOUN
bam-7218	1025	9	that	that	SCONJ
bam-7218	1025	10	skeletal	skeletal	ADJ
bam-7218	1025	11	muscle	muscle	NOUN
bam-7218	1025	12	progenitors	progenitor	NOUN
bam-7218	1025	13	,	,	PUNCT
bam-7218	1025	14	such	such	ADJ
bam-7218	1025	15	as	as	ADP
bam-7218	1025	16	satellite	satellite	NOUN
bam-7218	1025	17	cells	cell	NOUN
bam-7218	1025	18	,	,	PUNCT
bam-7218	1025	19	could	could	AUX
bam-7218	1025	20	give	give	VERB
bam-7218	1025	21	rise	rise	NOUN
bam-7218	1025	22	to	to	ADP
bam-7218	1025	23	rms	rm	NOUN
bam-7218	1025	24	even	even	ADV
bam-7218	1025	25	though	though	SCONJ
bam-7218	1025	26	alternative	alternative	ADJ
bam-7218	1025	27	theories	theory	NOUN
bam-7218	1025	28	point	point	VERB
bam-7218	1025	29	to	to	ADP
bam-7218	1025	30	mesenchymal	mesenchymal	ADJ
bam-7218	1025	31	stem	stem	NOUN
bam-7218	1025	32	cells	cell	NOUN
bam-7218	1025	33	or	or	CCONJ
bam-7218	1025	34	even	even	ADV
bam-7218	1025	35	progenitors	progenitor	NOUN
bam-7218	1025	36	of	of	ADP
bam-7218	1025	37	the	the	DET
bam-7218	1025	38	adipocyte	adipocyte	ADJ
bam-7218	1025	39	lineage	lineage	NOUN
bam-7218	1025	40	,	,	PUNCT
bam-7218	1025	41	as	as	ADP
bam-7218	1025	42	possible	possible	ADJ
bam-7218	1025	43	tumor	tumor	NOUN
bam-7218	1025	44	-	-	PUNCT
bam-7218	1025	45	initiating	initiate	VERB
bam-7218	1025	46	cells	cell	NOUN
bam-7218	1025	47	.	.	PUNCT
bam-7218	1026	1	the	the	DET
bam-7218	1026	2	clinical	clinical	ADJ
bam-7218	1026	3	differences	difference	NOUN
bam-7218	1026	4	between	between	ADP
bam-7218	1026	5	the	the	DET
bam-7218	1026	6	two	two	NUM
bam-7218	1026	7	rms	rm	NOUN
bam-7218	1026	8	types	type	NOUN
bam-7218	1026	9	result	result	VERB
bam-7218	1026	10	from	from	ADP
bam-7218	1026	11	different	different	ADJ
bam-7218	1026	12	molecular	molecular	ADJ
bam-7218	1026	13	genetic	genetic	ADJ
bam-7218	1026	14	mechanisms	mechanism	NOUN
bam-7218	1026	15	of	of	ADP
bam-7218	1026	16	origin	origin	NOUN
bam-7218	1026	17	.	.	PUNCT
bam-7218	1027	1	to	to	PART
bam-7218	1027	2	study	study	VERB
bam-7218	1027	3	the	the	DET
bam-7218	1027	4	erms	erm	NOUN
bam-7218	1027	5	,	,	PUNCT
bam-7218	1027	6	which	which	PRON
bam-7218	1027	7	is	be	AUX
bam-7218	1027	8	our	our	PRON
bam-7218	1027	9	main	main	ADJ
bam-7218	1027	10	focus	focus	NOUN
bam-7218	1027	11	,	,	PUNCT
bam-7218	1027	12	we	we	PRON
bam-7218	1027	13	adopted	adopt	VERB
bam-7218	1027	14	the	the	DET
bam-7218	1027	15	krasg12d/+trp53fl	krasg12d/+trp53fl	PROPN
bam-7218	1027	16	/	/	SYM
bam-7218	1027	17	fl	fl	PROPN
bam-7218	1027	18	conditional	conditional	PROPN
bam-7218	1027	19	mouse	mouse	NOUN
bam-7218	1027	20	model	model	NOUN
bam-7218	1027	21	to	to	PART
bam-7218	1027	22	induce	induce	VERB
bam-7218	1027	23	cell	cell	NOUN
bam-7218	1027	24	transformation	transformation	NOUN
bam-7218	1027	25	,	,	PUNCT
bam-7218	1027	26	by	by	ADP
bam-7218	1027	27	in	in	ADP
bam-7218	1027	28	vivo	vivo	NOUN
bam-7218	1027	29	or	or	CCONJ
bam-7218	1027	30	in	in	ADP
bam-7218	1027	31	vitro	vitro	X
bam-7218	1027	32	infecting	infect	VERB
bam-7218	1027	33	cells	cell	NOUN
bam-7218	1027	34	with	with	ADP
bam-7218	1027	35	an	an	DET
bam-7218	1027	36	adenovirus	adenovirus	NOUN
bam-7218	1027	37	vector	vector	NOUN
bam-7218	1027	38	expressing	express	VERB
bam-7218	1027	39	the	the	DET
bam-7218	1027	40	cre	cre	PROPN
bam-7218	1027	41	recombinase	recombinase	NOUN
bam-7218	1027	42	that	that	PRON
bam-7218	1027	43	leads	lead	VERB
bam-7218	1027	44	to	to	ADP
bam-7218	1027	45	the	the	DET
bam-7218	1027	46	constitutive	constitutive	ADJ
bam-7218	1027	47	activation	activation	NOUN
bam-7218	1027	48	of	of	ADP
bam-7218	1027	49	the	the	DET
bam-7218	1027	50	oncogene	oncogene	NOUN
bam-7218	1027	51	kras	kra	NOUN
bam-7218	1027	52	along	along	ADP
bam-7218	1027	53	with	with	ADP
bam-7218	1027	54	the	the	DET
bam-7218	1027	55	inactivation	inactivation	NOUN
bam-7218	1027	56	of	of	ADP
bam-7218	1027	57	the	the	DET
bam-7218	1027	58	p53	p53	NOUN
bam-7218	1027	59	tumor	tumor	NOUN
bam-7218	1027	60	suppressor	suppressor	NOUN
bam-7218	1027	61	gene	gene	NOUN
bam-7218	1027	62	.	.	PUNCT
bam-7218	1028	1	since	since	SCONJ
bam-7218	1028	2	our	our	PRON
bam-7218	1028	3	goal	goal	NOUN
bam-7218	1028	4	is	be	AUX
bam-7218	1028	5	to	to	PART
bam-7218	1028	6	identify	identify	VERB
bam-7218	1028	7	which	which	DET
bam-7218	1028	8	cell	cell	NOUN
bam-7218	1028	9	population(s	population(s	NOUN
bam-7218	1028	10	)	)	PUNCT
bam-7218	1028	11	can	can	AUX
bam-7218	1028	12	give	give	VERB
bam-7218	1028	13	rise	rise	NOUN
bam-7218	1028	14	to	to	ADP
bam-7218	1028	15	erms	erm	NOUN
bam-7218	1028	16	,	,	PUNCT
bam-7218	1028	17	we	we	PRON
bam-7218	1028	18	triggered	trigger	VERB
bam-7218	1028	19	embryonal	embryonal	ADJ
bam-7218	1028	20	rms	rm	NOUN
bam-7218	1028	21	formation	formation	NOUN
bam-7218	1028	22	by	by	ADP
bam-7218	1028	23	infecting	infect	VERB
bam-7218	1028	24	purified	purified	ADJ
bam-7218	1028	25	muscle	muscle	NOUN
bam-7218	1028	26	mononuclear	mononuclear	ADJ
bam-7218	1028	27	cell	cell	NOUN
bam-7218	1028	28	populations	population	NOUN
bam-7218	1028	29	with	with	ADP
bam-7218	1028	30	the	the	DET
bam-7218	1028	31	cre	cre	PROPN
bam-7218	1028	32	recombinase	recombinase	NOUN
bam-7218	1028	33	adenovirus	adenovirus	NOUN
bam-7218	1028	34	which	which	PRON
bam-7218	1028	35	activates	activate	VERB
bam-7218	1028	36	expression	expression	NOUN
bam-7218	1028	37	of	of	ADP
bam-7218	1028	38	kras(g12d	kras(g12d	PROPN
bam-7218	1028	39	)	)	PUNCT
bam-7218	1028	40	and	and	CCONJ
bam-7218	1028	41	inactivates	inactivate	VERB
bam-7218	1028	42	the	the	DET
bam-7218	1028	43	p53	p53	NOUN
bam-7218	1028	44	gene	gene	NOUN
bam-7218	1028	45	.	.	PUNCT
bam-7218	1029	1	both	both	DET
bam-7218	1029	2	satellites	satellite	NOUN
bam-7218	1029	3	and	and	CCONJ
bam-7218	1029	4	faps	fap	NOUN
bam-7218	1029	5	are	be	AUX
bam-7218	1029	6	transformed	transform	VERB
bam-7218	1029	7	in	in	ADP
bam-7218	1029	8	vitro	vitro	X
bam-7218	1029	9	by	by	ADP
bam-7218	1029	10	this	this	DET
bam-7218	1029	11	approach	approach	NOUN
bam-7218	1029	12	and	and	CCONJ
bam-7218	1029	13	induce	induce	VERB
bam-7218	1029	14	the	the	DET
bam-7218	1029	15	formation	formation	NOUN
bam-7218	1029	16	erms	erm	NOUN
bam-7218	1029	17	like	like	ADP
bam-7218	1029	18	tumors	tumor	NOUN
bam-7218	1029	19	when	when	SCONJ
bam-7218	1029	20	grafted	graft	VERB
bam-7218	1029	21	into	into	ADP
bam-7218	1029	22	nude	nude	ADJ
bam-7218	1029	23	mice	mouse	NOUN
bam-7218	1029	24	.	.	PUNCT
bam-7218	1030	1	we	we	PRON
bam-7218	1030	2	are	be	AUX
bam-7218	1030	3	in	in	ADP
bam-7218	1030	4	the	the	DET
bam-7218	1030	5	process	process	NOUN
bam-7218	1030	6	of	of	ADP
bam-7218	1030	7	characterizing	characterize	VERB
bam-7218	1030	8	the	the	DET
bam-7218	1030	9	changes	change	NOUN
bam-7218	1030	10	in	in	ADP
bam-7218	1030	11	the	the	DET
bam-7218	1030	12	cell	cell	NOUN
bam-7218	1030	13	populations	population	NOUN
bam-7218	1030	14	from	from	ADP
bam-7218	1030	15	the	the	DET
bam-7218	1030	16	tumor	tumor	NOUN
bam-7218	1030	17	mass	mass	NOUN
bam-7218	1030	18	,	,	PUNCT
bam-7218	1030	19	at	at	ADP
bam-7218	1030	20	different	different	ADJ
bam-7218	1030	21	stages	stage	NOUN
bam-7218	1030	22	of	of	ADP
bam-7218	1030	23	development	development	NOUN
bam-7218	1030	24	,	,	PUNCT
bam-7218	1030	25	by	by	ADP
bam-7218	1030	26	flow	flow	NOUN
bam-7218	1030	27	cytometry	cytometry	NOUN
bam-7218	1030	28	techniques	technique	NOUN
bam-7218	1030	29	.	.	PUNCT
bam-7218	1031	1	references	reference	NOUN
bam-7218	1031	2	:	:	PUNCT
bam-7218	1032	1	1	1	X
bam-7218	1032	2	.	.	X
bam-7218	1032	3	ognjanovic	ognjanovic	PROPN
bam-7218	1032	4	sa	sa	PROPN
bam-7218	1032	5	.	.	PUNCT
bam-7218	1032	6	et	et	PROPN
bam-7218	1032	7	al	al	PROPN
bam-7218	1032	8	.	.	PUNCT
bam-7218	1032	9	trends	trend	NOUN
bam-7218	1032	10	in	in	ADP
bam-7218	1032	11	childhood	childhood	ADJ
bam-7218	1032	12	rhabdomyo	rhabdomyo	ADJ
bam-7218	1032	13	-	-	PUNCT
bam-7218	1032	14	sarcoma	sarcoma	NOUN
bam-7218	1032	15	incidence	incidence	NOUN
bam-7218	1032	16	and	and	CCONJ
bam-7218	1032	17	survival	survival	NOUN
bam-7218	1032	18	in	in	ADP
bam-7218	1032	19	the	the	DET
bam-7218	1032	20	united	united	PROPN
bam-7218	1032	21	states	states	PROPN
bam-7218	1032	22	,	,	PUNCT
bam-7218	1032	23	1975	1975	NUM
bam-7218	1032	24	-	-	SYM
bam-7218	1032	25	2005	2005	NUM
bam-7218	1032	26	.	.	PUNCT
bam-7218	1033	1	cancer	cancer	NOUN
bam-7218	1033	2	2009;115:4218	2009;115:4218	NUM
bam-7218	1033	3	-	-	SYM
bam-7218	1033	4	26	26	NUM
bam-7218	1033	5	.	.	PUNCT
bam-7218	1033	6	2	2	X
bam-7218	1033	7	.	.	X
bam-7218	1033	8	saab	saab	PROPN
bam-7218	1033	9	r	r	PROPN
bam-7218	1033	10	,	,	PUNCT
bam-7218	1033	11	et	et	PROPN
bam-7218	1033	12	al	al	PROPN
bam-7218	1033	13	.	.	PROPN
bam-7218	1033	14	myogenesis	myogenesis	NOUN
bam-7218	1033	15	and	and	CCONJ
bam-7218	1033	16	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-7218	1033	17	:	:	PUNCT
bam-7218	1033	18	the	the	DET
bam-7218	1033	19	jekyll	jekyll	PROPN
bam-7218	1033	20	and	and	CCONJ
bam-7218	1033	21	hyde	hyde	PROPN
bam-7218	1033	22	of	of	ADP
bam-7218	1033	23	skeletal	skeletal	ADJ
bam-7218	1033	24	muscle	muscle	NOUN
bam-7218	1033	25	.	.	PUNCT
bam-7218	1034	1	curr	curr	PROPN
bam-7218	1034	2	top	top	PROPN
bam-7218	1034	3	dev	dev	PROPN
bam-7218	1034	4	bio	bio	NOUN
bam-7218	1034	5	2011;94:197	2011;94:197	PROPN
bam-7218	1034	6	-	-	SYM
bam-7218	1034	7	234	234	NUM
bam-7218	1034	8	.	.	PUNCT
bam-7218	1034	9	3	3	X
bam-7218	1034	10	.	.	X
bam-7218	1034	11	kirsch	kirsch	PROPN
bam-7218	1034	12	dg	dg	PROPN
bam-7218	1034	13	,	,	PUNCT
bam-7218	1034	14	et	et	PROPN
bam-7218	1034	15	al	al	PROPN
bam-7218	1034	16	.	.	PROPN
bam-7218	1034	17	kirsch	kirsch	PROPN
bam-7218	1034	18	dg	dg	PROPN
bam-7218	1034	19	,	,	PUNCT
bam-7218	1034	20	et	et	PROPN
bam-7218	1034	21	al	al	PROPN
bam-7218	1034	22	.	.	PUNCT
bam-7218	1035	1	a	a	DET
bam-7218	1035	2	spatially	spatially	ADV
bam-7218	1035	3	and	and	CCONJ
bam-7218	1035	4	temporally	temporally	ADV
bam-7218	1035	5	restricted	restrict	VERB
bam-7218	1035	6	mouse	mouse	NOUN
bam-7218	1035	7	model	model	NOUN
bam-7218	1035	8	of	of	ADP
bam-7218	1035	9	soft	soft	ADJ
bam-7218	1035	10	tissue	tissue	NOUN
bam-7218	1035	11	sarcoma	sarcoma	NOUN
bam-7218	1035	12	.	.	PUNCT
bam-7218	1036	1	nat	nat	PROPN
bam-7218	1036	2	med	me	VERB
bam-7218	1036	3	2007;13:992	2007;13:992	PROPN
bam-7218	1036	4	-	-	SYM
bam-7218	1036	5	7	7	NUM
bam-7218	1036	6	.	.	PUNCT
bam-7218	1036	7	p.19	p.19	NOUN
bam-7218	1036	8	amotl2	amotl2	NOUN
bam-7218	1036	9	and	and	CCONJ
bam-7218	1036	10	homer1	homer1	NOUN
bam-7218	1036	11	–	–	PUNCT
bam-7218	1036	12	novel	novel	ADJ
bam-7218	1036	13	regulators	regulator	NOUN
bam-7218	1036	14	of	of	ADP
bam-7218	1036	15	the	the	DET
bam-7218	1036	16	postsynaptic	postsynaptic	ADJ
bam-7218	1036	17	machinery	machinery	NOUN
bam-7218	1036	18	organization	organization	NOUN
bam-7218	1036	19	marta	marta	PROPN
bam-7218	1036	20	gawor	gawor	PROPN
bam-7218	1036	21	(	(	PUNCT
bam-7218	1036	22	a	a	PROPN
bam-7218	1036	23	)	)	PUNCT
bam-7218	1036	24	,	,	PUNCT
bam-7218	1036	25	paweł	paweł	VERB
bam-7218	1036	26	niewiadomski	niewiadomski	PROPN
bam-7218	1036	27	(	(	PUNCT
bam-7218	1036	28	a	a	NOUN
bam-7218	1036	29	)	)	PUNCT
bam-7218	1036	30	,	,	PUNCT
bam-7218	1036	31	anna	anna	PROPN
bam-7218	1036	32	protasiuk	protasiuk	NOUN
bam-7218	1036	33	(	(	PUNCT
bam-7218	1036	34	a	a	X
bam-7218	1036	35	)	)	PUNCT
bam-7218	1036	36	,	,	PUNCT
bam-7218	1036	37	bhola	bhola	PROPN
bam-7218	1036	38	shankar	shankar	PROPN
bam-7218	1036	39	pradhan	pradhan	PROPN
bam-7218	1036	40	(	(	PUNCT
bam-7218	1036	41	a	a	PROPN
bam-7218	1036	42	)	)	PUNCT
bam-7218	1036	43	,	,	PUNCT
bam-7218	1036	44	maria	maria	PROPN
bam-7218	1036	45	jolanta	jolanta	PROPN
bam-7218	1036	46	rędowicz	rędowicz	PROPN
bam-7218	1036	47	(	(	PUNCT
bam-7218	1036	48	b	b	NOUN
bam-7218	1036	49	)	)	PUNCT
bam-7218	1036	50	,	,	PUNCT
bam-7218	1036	51	tomasz	tomasz	PROPN
bam-7218	1036	52	jacek	jacek	PROPN
bam-7218	1036	53	prószyński	prószyński	PROPN
bam-7218	1036	54	(	(	PUNCT
bam-7218	1036	55	a	a	NOUN
bam-7218	1036	56	)	)	PUNCT
bam-7218	1036	57	(	(	PUNCT
bam-7218	1036	58	a	a	DET
bam-7218	1036	59	)	)	PUNCT
bam-7218	1036	60	nencki	nencki	PROPN
bam-7218	1036	61	institute	institute	PROPN
bam-7218	1036	62	of	of	ADP
bam-7218	1036	63	experimental	experimental	ADJ
bam-7218	1036	64	biology	biology	NOUN
bam-7218	1036	65	pas	pas	NOUN
bam-7218	1036	66	,	,	PUNCT
bam-7218	1036	67	laboratory	laboratory	NOUN
bam-7218	1036	68	of	of	ADP
bam-7218	1036	69	synaptogenesis	synaptogenesis	NOUN
bam-7218	1036	70	,	,	PUNCT
bam-7218	1036	71	poland	poland	PROPN
bam-7218	1036	72	;	;	PUNCT
bam-7218	1036	73	(	(	PUNCT
bam-7218	1036	74	b	b	X
bam-7218	1036	75	)	)	PUNCT
bam-7218	1036	76	nencki	nencki	PROPN
bam-7218	1036	77	institute	institute	PROPN
bam-7218	1036	78	of	of	ADP
bam-7218	1036	79	experimental	experimental	ADJ
bam-7218	1036	80	biology	biology	NOUN
bam-7218	1036	81	pas	pas	NOUN
bam-7218	1036	82	,	,	PUNCT
bam-7218	1036	83	laboratory	laboratory	NOUN
bam-7218	1036	84	of	of	ADP
bam-7218	1036	85	cell	cell	NOUN
bam-7218	1036	86	motility	motility	NOUN
bam-7218	1036	87	,	,	PUNCT
bam-7218	1036	88	poland	poland	PROPN
bam-7218	1036	89	email	email	NOUN
bam-7218	1036	90	:	:	PUNCT
bam-7218	1036	91	m.gawor@nencki.gov.pl	m.gawor@nencki.gov.pl	PROPN
bam-7218	1036	92	mammalian	mammalian	ADJ
bam-7218	1036	93	neuromuscular	neuromuscular	ADJ
bam-7218	1036	94	junctions	junction	NOUN
bam-7218	1036	95	(	(	PUNCT
bam-7218	1036	96	nmjs	nmj	NOUN
bam-7218	1036	97	)	)	PUNCT
bam-7218	1036	98	undergo	undergo	VERB
bam-7218	1036	99	a	a	DET
bam-7218	1036	100	postnatal	postnatal	ADJ
bam-7218	1036	101	topological	topological	ADJ
bam-7218	1036	102	transformation	transformation	NOUN
bam-7218	1036	103	from	from	ADP
bam-7218	1036	104	a	a	DET
bam-7218	1036	105	simple	simple	ADJ
bam-7218	1036	106	oval	oval	NOUN
bam-7218	1036	107	plaque	plaque	NOUN
bam-7218	1036	108	to	to	ADP
bam-7218	1036	109	a	a	DET
bam-7218	1036	110	complex	complex	ADJ
bam-7218	1036	111	branch	branch	NOUN
bam-7218	1036	112	-	-	PUNCT
bam-7218	1036	113	shaped	shape	VERB
bam-7218	1036	114	structure	structure	NOUN
bam-7218	1036	115	called	call	VERB
bam-7218	1036	116	“	"	PUNCT
bam-7218	1036	117	pretzel	pretzel	NOUN
bam-7218	1036	118	”	"	PUNCT
bam-7218	1036	119	.	.	PUNCT
bam-7218	1037	1	although	although	SCONJ
bam-7218	1037	2	abnormalities	abnormality	NOUN
bam-7218	1037	3	in	in	ADP
bam-7218	1037	4	nmj	nmj	NOUN
bam-7218	1037	5	maturation	maturation	NOUN
bam-7218	1037	6	and/or	and/or	CCONJ
bam-7218	1037	7	maintenance	maintenance	NOUN
bam-7218	1037	8	are	be	AUX
bam-7218	1037	9	frequently	frequently	ADV
bam-7218	1037	10	observed	observe	VERB
bam-7218	1037	11	in	in	ADP
bam-7218	1037	12	neuromuscular	neuromuscular	ADJ
bam-7218	1037	13	disorders	disorder	NOUN
bam-7218	1037	14	,	,	PUNCT
bam-7218	1037	15	such	such	ADJ
bam-7218	1037	16	as	as	ADP
bam-7218	1037	17	congenital	congenital	ADJ
bam-7218	1037	18	myasthenic	myasthenic	ADJ
bam-7218	1037	19	syndromes	syndrome	NOUN
bam-7218	1037	20	(	(	PUNCT
bam-7218	1037	21	cmss	cmss	NOUN
bam-7218	1037	22	)	)	PUNCT
bam-7218	1037	23	,	,	PUNCT
bam-7218	1037	24	the	the	DET
bam-7218	1037	25	mechanisms	mechanism	NOUN
bam-7218	1037	26	that	that	PRON
bam-7218	1037	27	govern	govern	VERB
bam-7218	1037	28	synaptic	synaptic	ADJ
bam-7218	1037	29	developmental	developmental	ADJ
bam-7218	1037	30	remodeling	remodeling	NOUN
bam-7218	1037	31	are	be	AUX
bam-7218	1037	32	poorly	poorly	ADV
bam-7218	1037	33	understood	understand	VERB
bam-7218	1037	34	.	.	PUNCT
bam-7218	1038	1	it	it	PRON
bam-7218	1038	2	was	be	AUX
bam-7218	1038	3	reported	report	VERB
bam-7218	1038	4	,	,	PUNCT
bam-7218	1038	5	that	that	SCONJ
bam-7218	1038	6	myotubes	myotube	NOUN
bam-7218	1038	7	when	when	SCONJ
bam-7218	1038	8	cultured	cultured	ADJ
bam-7218	1038	9	aneurally	aneurally	ADV
bam-7218	1038	10	on	on	ADP
bam-7218	1038	11	laminin	laminin	NOUN
bam-7218	1038	12	-	-	PUNCT
bam-7218	1038	13	coated	coat	VERB
bam-7218	1038	14	surfaces	surface	NOUN
bam-7218	1038	15	,	,	PUNCT
bam-7218	1038	16	form	form	NOUN
bam-7218	1038	17	complex	complex	ADJ
bam-7218	1038	18	postsynaptic	postsynaptic	ADJ
bam-7218	1038	19	machinery	machinery	NOUN
bam-7218	1038	20	,	,	PUNCT
bam-7218	1038	21	which	which	PRON
bam-7218	1038	22	resembles	resemble	VERB
bam-7218	1038	23	that	that	SCONJ
bam-7218	1038	24	at	at	ADP
bam-7218	1038	25	the	the	DET
bam-7218	1038	26	nmj	nmj	NOUN
bam-7218	1038	27	.	.	PUNCT
bam-7218	1039	1	interestingly	interestingly	ADV
bam-7218	1039	2	,	,	PUNCT
bam-7218	1039	3	assemblies	assembly	NOUN
bam-7218	1039	4	formed	form	VERB
bam-7218	1039	5	in	in	ADP
bam-7218	1039	6	vitro	vitro	X
bam-7218	1039	7	undergo	undergo	VERB
bam-7218	1039	8	similar	similar	ADJ
bam-7218	1039	9	stages	stage	NOUN
bam-7218	1039	10	in	in	ADP
bam-7218	1039	11	developmental	developmental	ADJ
bam-7218	1039	12	remodeling	remodeling	NOUN
bam-7218	1039	13	from	from	ADP
bam-7218	1039	14	“	"	PUNCT
bam-7218	1039	15	plaques	plaque	NOUN
bam-7218	1039	16	”	"	PUNCT
bam-7218	1039	17	to	to	ADP
bam-7218	1039	18	“	"	PUNCT
bam-7218	1039	19	pretzels	pretzel	NOUN
bam-7218	1039	20	”	"	PUNCT
bam-7218	1039	21	as	as	ADP
bam-7218	1039	22	the	the	DET
bam-7218	1039	23	nmj	nmj	PROPN
bam-7218	1039	24	postsynaptic	postsynaptic	ADJ
bam-7218	1039	25	machinery	machinery	NOUN
bam-7218	1039	26	in	in	ADP
bam-7218	1039	27	vivo	vivo	NOUN
bam-7218	1039	28	.	.	PUNCT
bam-7218	1040	1	we	we	PRON
bam-7218	1040	2	have	have	AUX
bam-7218	1040	3	recently	recently	ADV
bam-7218	1040	4	demonstrated	demonstrate	VERB
bam-7218	1040	5	that	that	SCONJ
bam-7218	1040	6	podosomes	podosome	NOUN
bam-7218	1040	7	,	,	PUNCT
bam-7218	1040	8	actin	actin	NOUN
bam-7218	1040	9	-	-	PUNCT
bam-7218	1040	10	rich	rich	ADJ
bam-7218	1040	11	adhesive	adhesive	ADJ
bam-7218	1040	12	organelles	organelle	NOUN
bam-7218	1040	13	,	,	PUNCT
bam-7218	1040	14	promote	promote	VERB
bam-7218	1040	15	the	the	DET
bam-7218	1040	16	remodeling	remodeling	NOUN
bam-7218	1040	17	process	process	NOUN
bam-7218	1040	18	in	in	ADP
bam-7218	1040	19	cultured	cultured	ADJ
bam-7218	1040	20	myotubes	myotube	NOUN
bam-7218	1040	21	and	and	CCONJ
bam-7218	1040	22	showed	show	VERB
bam-7218	1040	23	a	a	DET
bam-7218	1040	24	key	key	ADJ
bam-7218	1040	25	role	role	NOUN
bam-7218	1040	26	of	of	ADP
bam-7218	1040	27	scaffolding	scaffold	VERB
bam-7218	1040	28	protein	protein	NOUN
bam-7218	1040	29	amotl2	amotl2	NOUN
bam-7218	1040	30	,	,	PUNCT
bam-7218	1040	31	which	which	PRON
bam-7218	1040	32	is	be	AUX
bam-7218	1040	33	localized	localize	VERB
bam-7218	1040	34	at	at	ADP
bam-7218	1040	35	podosomes	podosome	NOUN
bam-7218	1040	36	.	.	PUNCT
bam-7218	1041	1	we	we	PRON
bam-7218	1041	2	now	now	ADV
bam-7218	1041	3	report	report	VERB
bam-7218	1041	4	that	that	SCONJ
bam-7218	1041	5	in	in	ADP
bam-7218	1041	6	muscle	muscle	NOUN
bam-7218	1041	7	cells	cell	NOUN
bam-7218	1041	8	amotl2	amotl2	NOUN
bam-7218	1041	9	interacts	interact	VERB
bam-7218	1041	10	with	with	ADP
bam-7218	1041	11	one	one	NUM
bam-7218	1041	12	of	of	ADP
bam-7218	1041	13	the	the	DET
bam-7218	1041	14	key	key	ADJ
bam-7218	1041	15	synaptic	synaptic	ADJ
bam-7218	1041	16	components	component	NOUN
bam-7218	1041	17	,	,	PUNCT
bam-7218	1041	18	homer1	homer1	PROPN
bam-7218	1041	19	.	.	PUNCT
bam-7218	1042	1	mice	mouse	NOUN
bam-7218	1042	2	lacking	lack	VERB
bam-7218	1042	3	homer1	homer1	NOUN
bam-7218	1042	4	expression	expression	NOUN
bam-7218	1042	5	exhibit	exhibit	VERB
bam-7218	1042	6	skeletal	skeletal	ADJ
bam-7218	1042	7	muscle	muscle	NOUN
bam-7218	1042	8	myopathy	myopathy	ADJ
bam-7218	1042	9	characterized	characterize	VERB
bam-7218	1042	10	by	by	ADP
bam-7218	1042	11	disturbed	disturbed	ADJ
bam-7218	1042	12	calcium	calcium	NOUN
bam-7218	1042	13	homeostasis	homeostasis	NOUN
bam-7218	1042	14	.	.	PUNCT
bam-7218	1043	1	additionally	additionally	ADV
bam-7218	1043	2	,	,	PUNCT
bam-7218	1043	3	it	it	PRON
bam-7218	1043	4	has	have	AUX
bam-7218	1043	5	been	be	AUX
bam-7218	1043	6	shown	show	VERB
bam-7218	1043	7	that	that	SCONJ
bam-7218	1043	8	homer1	homer1	NOUN
bam-7218	1043	9	expression	expression	NOUN
bam-7218	1043	10	is	be	AUX
bam-7218	1043	11	affected	affect	VERB
bam-7218	1043	12	in	in	ADP
bam-7218	1043	13	mouse	mouse	NOUN
bam-7218	1043	14	models	model	NOUN
bam-7218	1043	15	of	of	ADP
bam-7218	1043	16	amyotrophic	amyotrophic	ADJ
bam-7218	1043	17	lateral	lateral	ADJ
bam-7218	1043	18	sclerosis	sclerosis	NOUN
bam-7218	1043	19	(	(	PUNCT
bam-7218	1043	20	als	als	NOUN
bam-7218	1043	21	)	)	PUNCT
bam-7218	1043	22	and	and	CCONJ
bam-7218	1043	23	duchenne	duchenne	PROPN
bam-7218	1043	24	’s	’s	PART
bam-7218	1043	25	muscular	muscular	ADJ
bam-7218	1043	26	dystrophy	dystrophy	NOUN
bam-7218	1043	27	(	(	PUNCT
bam-7218	1043	28	dmd	dmd	NOUN
bam-7218	1043	29	)	)	PUNCT
bam-7218	1043	30	.	.	PUNCT
bam-7218	1044	1	we	we	PRON
bam-7218	1044	2	show	show	VERB
bam-7218	1044	3	that	that	SCONJ
bam-7218	1044	4	homer1	homer1	NOUN
bam-7218	1044	5	,	,	PUNCT
bam-7218	1044	6	together	together	ADV
bam-7218	1044	7	with	with	ADP
bam-7218	1044	8	amotl2	amotl2	NOUN
bam-7218	1044	9	are	be	AUX
bam-7218	1044	10	concentrated	concentrate	VERB
bam-7218	1044	11	at	at	ADP
bam-7218	1044	12	postsynaptic	postsynaptic	ADJ
bam-7218	1044	13	areas	area	NOUN
bam-7218	1044	14	of	of	ADP
bam-7218	1044	15	nmjs	nmj	NOUN
bam-7218	1044	16	in	in	ADP
bam-7218	1044	17	the	the	DET
bam-7218	1044	18	indentations	indentation	NOUN
bam-7218	1044	19	between	between	ADP
bam-7218	1044	20	the	the	DET
bam-7218	1044	21	acetylcholine	acetylcholine	NOUN
bam-7218	1044	22	receptor	receptor	NOUN
bam-7218	1044	23	-	-	PUNCT
bam-7218	1044	24	rich	rich	ADJ
bam-7218	1044	25	branches	branch	NOUN
bam-7218	1044	26	.	.	PUNCT
bam-7218	1045	1	we	we	PRON
bam-7218	1045	2	also	also	ADV
bam-7218	1045	3	demonstrate	demonstrate	VERB
bam-7218	1045	4	that	that	SCONJ
bam-7218	1045	5	homer1	homer1	NOUN
bam-7218	1045	6	is	be	AUX
bam-7218	1045	7	indispensable	indispensable	ADJ
bam-7218	1045	8	for	for	ADP
bam-7218	1045	9	achr	achr	PROPN
bam-7218	1045	10	clustering	cluster	VERB
bam-7218	1045	11	in	in	ADP
bam-7218	1045	12	the	the	DET
bam-7218	1045	13	cultured	cultured	ADJ
bam-7218	1045	14	myotubes	myotube	NOUN
bam-7218	1045	15	and	and	CCONJ
bam-7218	1045	16	identify	identify	VERB
bam-7218	1045	17	homer1	homer1	NOUN
bam-7218	1045	18	-	-	PUNCT
bam-7218	1045	19	interacting	interact	VERB
bam-7218	1045	20	proteins	protein	NOUN
bam-7218	1045	21	that	that	PRON
bam-7218	1045	22	are	be	AUX
bam-7218	1045	23	involved	involve	VERB
bam-7218	1045	24	in	in	ADP
bam-7218	1045	25	this	this	DET
bam-7218	1045	26	process	process	NOUN
bam-7218	1045	27	.	.	PUNCT
bam-7218	1046	1	our	our	PRON
bam-7218	1046	2	results	result	NOUN
bam-7218	1046	3	provide	provide	VERB
bam-7218	1046	4	novel	novel	ADJ
bam-7218	1046	5	insight	insight	NOUN
bam-7218	1046	6	into	into	ADP
bam-7218	1046	7	molecular	molecular	ADJ
bam-7218	1046	8	machinery	machinery	NOUN
bam-7218	1046	9	that	that	PRON
bam-7218	1046	10	is	be	AUX
bam-7218	1046	11	orchestrating	orchestrate	VERB
bam-7218	1046	12	postsynaptic	postsynaptic	ADJ
bam-7218	1046	13	machinery	machinery	NOUN
bam-7218	1046	14	development	development	NOUN
bam-7218	1046	15	.	.	PUNCT
bam-7218	1047	1	supported	support	VERB
bam-7218	1047	2	by	by	ADP
bam-7218	1047	3	the	the	DET
bam-7218	1047	4	national	national	PROPN
bam-7218	1047	5	science	science	PROPN
bam-7218	1047	6	centre	centre	NOUN
bam-7218	1047	7	grants	grant	VERB
bam-7218	1047	8	2012/05	2012/05	NUM
bam-7218	1047	9	/	/	SYM
bam-7218	1047	10	e	e	NOUN
bam-7218	1047	11	/	/	SYM
bam-7218	1047	12	nz3/00487	nz3/00487	PROPN
bam-7218	1047	13	,	,	PUNCT
bam-7218	1047	14	2014/13	2014/13	NUM
bam-7218	1047	15	/	/	SYM
bam-7218	1047	16	b	b	NOUN
bam-7218	1047	17	/	/	SYM
bam-7218	1047	18	nz3/00909	nz3/00909	PROPN
bam-7218	1047	19	and	and	CCONJ
bam-7218	1047	20	2016/21	2016/21	NUM
bam-7218	1047	21	/	/	SYM
bam-7218	1047	22	d	d	PROPN
bam-7218	1047	23	/	/	SYM
bam-7218	1047	24	nz4/03069	nz4/03069	PROPN
bam-7218	1047	25	.	.	PUNCT
bam-7218	1048	1	p.20	p.20	X
bam-7218	1048	2	biochemical	biochemical	ADJ
bam-7218	1048	3	investigations	investigation	NOUN
bam-7218	1048	4	to	to	PART
bam-7218	1048	5	unravel	unravel	VERB
bam-7218	1048	6	myopathological	myopathological	ADJ
bam-7218	1048	7	perturbations	perturbation	NOUN
bam-7218	1048	8	caused	cause	VERB
bam-7218	1048	9	by	by	ADP
bam-7218	1048	10	the	the	DET
bam-7218	1048	11	caveolin-3	caveolin-3	NUM
bam-7218	1048	12	p.p104l	p.p104l	PROPN
bam-7218	1048	13	mutation	mutation	PROPN
bam-7218	1048	14	josé	josé	PROPN
bam-7218	1048	15	andrés	andrés	PROPN
bam-7218	1048	16	gonzález	gonzález	PROPN
bam-7218	1048	17	-	-	PUNCT
bam-7218	1048	18	coraspe	coraspe	PROPN
bam-7218	1048	19	(	(	PUNCT
bam-7218	1048	20	a	a	NOUN
bam-7218	1048	21	)	)	PUNCT
bam-7218	1048	22	,	,	PUNCT
bam-7218	1048	23	erik	erik	PROPN
bam-7218	1048	24	freier	freier	PROPN
bam-7218	1048	25	(	(	PUNCT
bam-7218	1048	26	b	b	NOUN
bam-7218	1048	27	)	)	PUNCT
bam-7218	1048	28	,	,	PUNCT
bam-7218	1048	29	hanns	hann	NOUN
bam-7218	1048	30	lochmüller	lochmüll	ADJ
bam-7218	1048	31	(	(	PUNCT
bam-7218	1048	32	c	c	NOUN
bam-7218	1048	33	)	)	PUNCT
bam-7218	1048	34	,	,	PUNCT
bam-7218	1048	35	stephanie	stephanie	PROPN
bam-7218	1048	36	carr	carr	PROPN
bam-7218	1048	37	(	(	PUNCT
bam-7218	1048	38	c	c	NOUN
bam-7218	1048	39	)	)	PUNCT
bam-7218	1048	40	,	,	PUNCT
bam-7218	1048	41	stephan	stephan	PROPN
bam-7218	1048	42	buchkremer	buchkremer	PROPN
bam-7218	1048	43	(	(	PUNCT
bam-7218	1048	44	a	a	NOUN
bam-7218	1048	45	)	)	PUNCT
bam-7218	1048	46	,	,	PUNCT
bam-7218	1048	47	rené	rené	PROPN
bam-7218	1048	48	zahedi	zahedi	PROPN
bam-7218	1048	49	(	(	PUNCT
bam-7218	1048	50	b	b	PROPN
bam-7218	1048	51	)	)	PUNCT
bam-7218	1048	52	eva	eva	PROPN
bam-7218	1048	53	brauer	brauer	PROPN
bam-7218	1048	54	(	(	PUNCT
bam-7218	1048	55	a	a	PROPN
bam-7218	1048	56	)	)	PUNCT
bam-7218	1048	57	,	,	PUNCT
bam-7218	1048	58	mailto:c.fuoco@yahoo.it	mailto:c.fuoco@yahoo.it	PROPN
bam-7218	1048	59	mailto:m.gawor@nencki.gov.pl	mailto:m.gawor@nencki.gov.pl	PROPN
bam-7218	1048	60	14	14	NUM
bam-7218	1048	61	th	th	NOUN
bam-7218	1048	62	iiim	iiim	NOUN
bam-7218	1048	63	meeting	meeting	NOUN
bam-7218	1048	64	,	,	PUNCT
bam-7218	1048	65	assisi	assisi	PROPN
bam-7218	1048	66	,	,	PUNCT
bam-7218	1048	67	italy	italy	PROPN
bam-7218	1048	68	october	october	PROPN
bam-7218	1048	69	12	12	NUM
bam-7218	1048	70	-	-	SYM
bam-7218	1048	71	15	15	NUM
bam-7218	1048	72	2017	2017	NUM
bam-7218	1048	73	eur	eur	PROPN
bam-7218	1048	74	j	j	PROPN
bam-7218	1048	75	transl	transl	PROPN
bam-7218	1048	76	myol	myol	ADV
bam-7218	1048	77	27	27	NUM
bam-7218	1048	78	(	(	PUNCT
bam-7218	1048	79	4	4	NUM
bam-7218	1048	80	):	):	SYM
bam-7218	1048	81	185	185	NUM
bam-7218	1048	82	-	-	SYM
bam-7218	1048	83	224	224	NUM
bam-7218	1048	84	217	217	NUM
bam-7218	1048	85	hannah	hannah	PROPN
bam-7218	1048	86	michels	michels	PROPN
bam-7218	1048	87	(	(	PUNCT
bam-7218	1048	88	b	b	NOUN
bam-7218	1048	89	)	)	PUNCT
bam-7218	1048	90	,	,	PUNCT
bam-7218	1048	91	yoshihide	yoshihide	NOUN
bam-7218	1048	92	sunada	sunada	NOUN
bam-7218	1048	93	(	(	PUNCT
bam-7218	1048	94	d	d	NOUN
bam-7218	1048	95	)	)	PUNCT
bam-7218	1048	96	,	,	PUNCT
bam-7218	1048	97	joachim	joachim	PROPN
bam-7218	1048	98	weis	weis	PROPN
bam-7218	1048	99	(	(	PUNCT
bam-7218	1048	100	a	a	X
bam-7218	1048	101	)	)	PUNCT
bam-7218	1048	102	,	,	PUNCT
bam-7218	1048	103	denisa	denisa	NOUN
bam-7218	1048	104	hathazi	hathazi	NOUN
bam-7218	1048	105	(	(	PUNCT
bam-7218	1048	106	b	b	NOUN
bam-7218	1048	107	)	)	PUNCT
bam-7218	1048	108	*	*	PUNCT
bam-7218	1048	109	,	,	PUNCT
bam-7218	1048	110	andreas	andreas	PROPN
bam-7218	1048	111	roos	roos	PROPN
bam-7218	1048	112	(	(	PUNCT
bam-7218	1048	113	a	a	DET
bam-7218	1048	114	,	,	PUNCT
bam-7218	1048	115	b	b	NOUN
bam-7218	1048	116	,	,	PUNCT
bam-7218	1048	117	c	c	NOUN
bam-7218	1048	118	)	)	PUNCT
bam-7218	1048	119	*	*	PUNCT
bam-7218	1048	120	#	#	NOUN
bam-7218	1048	121	(	(	PUNCT
bam-7218	1048	122	a	a	PRON
bam-7218	1048	123	)	)	PUNCT
bam-7218	1048	124	institute	institute	NOUN
bam-7218	1048	125	of	of	ADP
bam-7218	1048	126	neuropathology	neuropathology	NOUN
bam-7218	1048	127	,	,	PUNCT
bam-7218	1048	128	rwth	rwth	PROPN
bam-7218	1048	129	aachen	aachen	PROPN
bam-7218	1048	130	university	university	PROPN
bam-7218	1048	131	hospital	hospital	NOUN
bam-7218	1048	132	,	,	PUNCT
bam-7218	1048	133	aachen	aachen	PROPN
bam-7218	1048	134	;	;	PUNCT
bam-7218	1048	135	(	(	PUNCT
bam-7218	1048	136	b	b	X
bam-7218	1048	137	)	)	PUNCT
bam-7218	1048	138	leibniz	leibniz	PROPN
bam-7218	1048	139	-	-	PUNCT
bam-7218	1048	140	institut	institut	PROPN
bam-7218	1048	141	für	für	PROPN
bam-7218	1048	142	analytische	analytische	PROPN
bam-7218	1048	143	wissenschaften	wissenschaften	VERB
bam-7218	1048	144	isas	isas	PROPN
bam-7218	1048	145	e.v	e.v	PROPN
bam-7218	1048	146	,	,	PUNCT
bam-7218	1048	147	dortmund	dortmund	PROPN
bam-7218	1048	148	,	,	PUNCT
bam-7218	1048	149	germany	germany	PROPN
bam-7218	1048	150	;	;	PUNCT
bam-7218	1048	151	(	(	PUNCT
bam-7218	1048	152	c	c	X
bam-7218	1048	153	)	)	PUNCT
bam-7218	1048	154	institute	institute	NOUN
bam-7218	1048	155	of	of	ADP
bam-7218	1048	156	genetic	genetic	ADJ
bam-7218	1048	157	medicine	medicine	NOUN
bam-7218	1048	158	,	,	PUNCT
bam-7218	1048	159	john	john	PROPN
bam-7218	1048	160	walton	walton	PROPN
bam-7218	1048	161	muscular	muscular	ADJ
bam-7218	1048	162	dystrophy	dystrophy	NOUN
bam-7218	1048	163	research	research	NOUN
bam-7218	1048	164	centre	centre	NOUN
bam-7218	1048	165	,	,	PUNCT
bam-7218	1048	166	international	international	ADJ
bam-7218	1048	167	centre	centre	NOUN
bam-7218	1048	168	for	for	ADP
bam-7218	1048	169	life	life	NOUN
bam-7218	1048	170	,	,	PUNCT
bam-7218	1048	171	newcastle	newcastle	PROPN
bam-7218	1048	172	upon	upon	SCONJ
bam-7218	1048	173	tyne	tyne	PROPN
bam-7218	1048	174	,	,	PUNCT
bam-7218	1048	175	england	england	PROPN
bam-7218	1048	176	,	,	PUNCT
bam-7218	1048	177	uk	uk	PROPN
bam-7218	1048	178	;	;	PUNCT
bam-7218	1048	179	(	(	PUNCT
bam-7218	1048	180	d	d	X
bam-7218	1048	181	)	)	PUNCT
bam-7218	1048	182	department	department	NOUN
bam-7218	1048	183	of	of	ADP
bam-7218	1048	184	neurology	neurology	NOUN
bam-7218	1048	185	,	,	PUNCT
bam-7218	1048	186	kawasaki	kawasaki	PROPN
bam-7218	1048	187	medical	medical	PROPN
bam-7218	1048	188	school	school	PROPN
bam-7218	1048	189	,	,	PUNCT
bam-7218	1048	190	okayama	okayama	PROPN
bam-7218	1048	191	,	,	PUNCT
bam-7218	1048	192	japan	japan	PROPN
bam-7218	1048	193	email	email	NOUN
bam-7218	1048	194	:	:	PUNCT
bam-7218	1049	1	jandresgonzalezc@gmail.com	jandresgonzalezc@gmail.com	X
bam-7218	1050	1	caveolin-3	caveolin-3	INTJ
bam-7218	1050	2	(	(	PUNCT
bam-7218	1050	3	cav3	cav3	PROPN
bam-7218	1050	4	)	)	PUNCT
bam-7218	1050	5	is	be	AUX
bam-7218	1050	6	a	a	DET
bam-7218	1050	7	muscle	muscle	NOUN
bam-7218	1050	8	specific	specific	ADJ
bam-7218	1050	9	protein	protein	NOUN
bam-7218	1050	10	localized	localize	VERB
bam-7218	1050	11	to	to	ADP
bam-7218	1050	12	the	the	DET
bam-7218	1050	13	sarcolemma	sarcolemma	NOUN
bam-7218	1050	14	where	where	SCONJ
bam-7218	1050	15	it	it	PRON
bam-7218	1050	16	interacts	interact	VERB
bam-7218	1050	17	with	with	ADP
bam-7218	1050	18	the	the	DET
bam-7218	1050	19	dystroglycan	dystroglycan	ADJ
bam-7218	1050	20	complex	complex	NOUN
bam-7218	1050	21	(	(	PUNCT
bam-7218	1050	22	dgc	dgc	NOUN
bam-7218	1050	23	)	)	PUNCT
bam-7218	1050	24	and	and	CCONJ
bam-7218	1050	25	is	be	AUX
bam-7218	1050	26	thus	thus	ADV
bam-7218	1050	27	involved	involve	VERB
bam-7218	1050	28	in	in	ADP
bam-7218	1050	29	the	the	DET
bam-7218	1050	30	connection	connection	NOUN
bam-7218	1050	31	between	between	ADP
bam-7218	1050	32	the	the	DET
bam-7218	1050	33	extracellular	extracellular	ADJ
bam-7218	1050	34	matrix	matrix	NOUN
bam-7218	1050	35	(	(	PUNCT
bam-7218	1050	36	ecm	ecm	PROPN
bam-7218	1050	37	)	)	PUNCT
bam-7218	1050	38	and	and	CCONJ
bam-7218	1050	39	the	the	DET
bam-7218	1050	40	cytoskeleton	cytoskeleton	PROPN
bam-7218	1050	41	.	.	PUNCT
bam-7218	1051	1	muscle	muscle	NOUN
bam-7218	1051	2	diseases	disease	NOUN
bam-7218	1051	3	caused	cause	VERB
bam-7218	1051	4	by	by	ADP
bam-7218	1051	5	mutations	mutation	NOUN
bam-7218	1051	6	in	in	ADP
bam-7218	1051	7	the	the	DET
bam-7218	1051	8	cav3	cav3	ADJ
bam-7218	1051	9	gene	gene	NOUN
bam-7218	1051	10	are	be	AUX
bam-7218	1051	11	called	call	VERB
bam-7218	1051	12	caveolinopathies	caveolinopathie	NOUN
bam-7218	1051	13	.	.	PUNCT
bam-7218	1052	1	so	so	ADV
bam-7218	1052	2	far	far	ADV
bam-7218	1052	3	,	,	PUNCT
bam-7218	1052	4	more	more	ADJ
bam-7218	1052	5	than	than	ADP
bam-7218	1052	6	40	40	NUM
bam-7218	1052	7	dominant	dominant	ADJ
bam-7218	1052	8	pathogenic	pathogenic	ADJ
bam-7218	1052	9	mutations	mutation	NOUN
bam-7218	1052	10	have	have	AUX
bam-7218	1052	11	been	be	AUX
bam-7218	1052	12	described	describe	VERB
bam-7218	1052	13	leading	lead	VERB
bam-7218	1052	14	to	to	ADP
bam-7218	1052	15	different	different	ADJ
bam-7218	1052	16	phenotypes	phenotype	NOUN
bam-7218	1052	17	molecularly	molecularly	ADV
bam-7218	1052	18	associated	associate	VERB
bam-7218	1052	19	with	with	ADP
bam-7218	1052	20	a	a	DET
bam-7218	1052	21	mis	mis	NOUN
bam-7218	1052	22	-	-	NOUN
bam-7218	1052	23	localization	localization	NOUN
bam-7218	1052	24	of	of	ADP
bam-7218	1052	25	the	the	DET
bam-7218	1052	26	mutant	mutant	ADJ
bam-7218	1052	27	protein	protein	NOUN
bam-7218	1052	28	to	to	ADP
bam-7218	1052	29	the	the	DET
bam-7218	1052	30	golgi	golgi	NOUN
bam-7218	1052	31	.	.	PUNCT
bam-7218	1053	1	hereby	hereby	ADV
bam-7218	1053	2	,	,	PUNCT
bam-7218	1053	3	associated	associate	VERB
bam-7218	1053	4	endoplasmic	endoplasmic	ADJ
bam-7218	1053	5	reticulum	reticulum	NOUN
bam-7218	1053	6	(	(	PUNCT
bam-7218	1053	7	er)-stress	er)-stress	NOUN
bam-7218	1053	8	has	have	AUX
bam-7218	1053	9	been	be	AUX
bam-7218	1053	10	demonstrated	demonstrate	VERB
bam-7218	1053	11	for	for	ADP
bam-7218	1053	12	the	the	DET
bam-7218	1053	13	p.p104l	p.p104l	NOUN
bam-7218	1053	14	mutation	mutation	NOUN
bam-7218	1053	15	.	.	PUNCT
bam-7218	1054	1	however	however	ADV
bam-7218	1054	2	,	,	PUNCT
bam-7218	1054	3	the	the	DET
bam-7218	1054	4	further	further	ADJ
bam-7218	1054	5	pathophysiological	pathophysiological	ADJ
bam-7218	1054	6	consequences	consequence	NOUN
bam-7218	1054	7	of	of	ADP
bam-7218	1054	8	mutant	mutant	ADJ
bam-7218	1054	9	cav3	cav3	ADJ
bam-7218	1054	10	mislocalization	mislocalization	NOUN
bam-7218	1054	11	and	and	CCONJ
bam-7218	1054	12	er	er	INTJ
bam-7218	1054	13	-	-	PUNCT
bam-7218	1054	14	stress	stress	NOUN
bam-7218	1054	15	remained	remain	VERB
bam-7218	1054	16	elusive	elusive	ADJ
bam-7218	1054	17	.	.	PUNCT
bam-7218	1055	1	utilizing	utilize	VERB
bam-7218	1055	2	a	a	DET
bam-7218	1055	3	transgenic	transgenic	NOUN
bam-7218	1055	4	(	(	PUNCT
bam-7218	1055	5	p.p104l	p.p104l	PROPN
bam-7218	1055	6	)	)	PUNCT
bam-7218	1055	7	mouse	mouse	NOUN
bam-7218	1055	8	model	model	NOUN
bam-7218	1055	9	of	of	ADP
bam-7218	1055	10	caveolinopathy	caveolinopathy	ADJ
bam-7218	1055	11	and	and	CCONJ
bam-7218	1055	12	performing	perform	VERB
bam-7218	1055	13	proteomic	proteomic	ADJ
bam-7218	1055	14	profiling	profiling	NOUN
bam-7218	1055	15	along	along	ADP
bam-7218	1055	16	with	with	ADP
bam-7218	1055	17	immunoblot	immunoblot	NOUN
bam-7218	1055	18	and	and	CCONJ
bam-7218	1055	19	morphological	morphological	ADJ
bam-7218	1055	20	studies	study	NOUN
bam-7218	1055	21	(	(	PUNCT
bam-7218	1055	22	including	include	VERB
bam-7218	1055	23	electron	electron	NOUN
bam-7218	1055	24	and	and	CCONJ
bam-7218	1055	25	cars	car	NOUN
bam-7218	1055	26	microscopy	microscopy	VERB
bam-7218	1055	27	)	)	PUNCT
bam-7218	1055	28	we	we	PRON
bam-7218	1055	29	systematically	systematically	ADV
bam-7218	1055	30	addressed	address	VERB
bam-7218	1055	31	these	these	DET
bam-7218	1055	32	consequences	consequence	NOUN
bam-7218	1055	33	.	.	PUNCT
bam-7218	1056	1	our	our	PRON
bam-7218	1056	2	morphological	morphological	ADJ
bam-7218	1056	3	studies	study	NOUN
bam-7218	1056	4	revealed	reveal	VERB
bam-7218	1056	5	golgi	golgi	PROPN
bam-7218	1056	6	and	and	CCONJ
bam-7218	1056	7	er	er	INTJ
bam-7218	1056	8	proliferations	proliferation	NOUN
bam-7218	1056	9	as	as	ADV
bam-7218	1056	10	well	well	ADV
bam-7218	1056	11	as	as	ADP
bam-7218	1056	12	the	the	DET
bam-7218	1056	13	build	build	NOUN
bam-7218	1056	14	-	-	PUNCT
bam-7218	1056	15	up	up	NOUN
bam-7218	1056	16	of	of	ADP
bam-7218	1056	17	protein	protein	NOUN
bam-7218	1056	18	aggregates	aggregate	NOUN
bam-7218	1056	19	.	.	PUNCT
bam-7218	1057	1	these	these	DET
bam-7218	1057	2	observations	observation	NOUN
bam-7218	1057	3	were	be	AUX
bam-7218	1057	4	confirmed	confirm	VERB
bam-7218	1057	5	via	via	ADP
bam-7218	1057	6	immunological	immunological	ADJ
bam-7218	1057	7	studies	study	NOUN
bam-7218	1057	8	and	and	CCONJ
bam-7218	1057	9	are	be	AUX
bam-7218	1057	10	in	in	ADP
bam-7218	1057	11	accordance	accordance	NOUN
bam-7218	1057	12	with	with	ADP
bam-7218	1057	13	our	our	PRON
bam-7218	1057	14	proteomic	proteomic	ADJ
bam-7218	1057	15	data	datum	NOUN
bam-7218	1057	16	showing	show	VERB
bam-7218	1057	17	altered	altered	ADJ
bam-7218	1057	18	abundance	abundance	NOUN
bam-7218	1057	19	of	of	ADP
bam-7218	1057	20	120	120	NUM
bam-7218	1057	21	proteins	protein	NOUN
bam-7218	1057	22	in	in	ADP
bam-7218	1057	23	diseased	diseased	ADJ
bam-7218	1057	24	quadriceps	quadricep	NOUN
bam-7218	1057	25	muscle	muscle	NOUN
bam-7218	1057	26	fibres	fibre	NOUN
bam-7218	1057	27	.	.	PUNCT
bam-7218	1058	1	proteomic	proteomic	ADJ
bam-7218	1058	2	findings	finding	NOUN
bam-7218	1058	3	indicated	indicate	VERB
bam-7218	1058	4	ecm	ecm	NOUN
bam-7218	1058	5	remodeling	remodeling	NOUN
bam-7218	1058	6	and	and	CCONJ
bam-7218	1058	7	cytoskeletal	cytoskeletal	ADJ
bam-7218	1058	8	vulnerability	vulnerability	NOUN
bam-7218	1058	9	.	.	PUNCT
bam-7218	1059	1	moreover	moreover	ADV
bam-7218	1059	2	,	,	PUNCT
bam-7218	1059	3	our	our	PRON
bam-7218	1059	4	proteomic	proteomic	ADJ
bam-7218	1059	5	findings	finding	NOUN
bam-7218	1059	6	suggested	suggest	VERB
bam-7218	1059	7	that	that	SCONJ
bam-7218	1059	8	further	further	ADJ
bam-7218	1059	9	dgc	dgc	NOUN
bam-7218	1059	10	components	component	NOUN
bam-7218	1059	11	are	be	AUX
bam-7218	1059	12	affected	affect	VERB
bam-7218	1059	13	by	by	ADP
bam-7218	1059	14	the	the	DET
bam-7218	1059	15	perturbed	perturb	VERB
bam-7218	1059	16	protein	protein	NOUN
bam-7218	1059	17	processing	processing	NOUN
bam-7218	1059	18	machinery	machinery	NOUN
bam-7218	1059	19	leading	lead	VERB
bam-7218	1059	20	to	to	ADP
bam-7218	1059	21	the	the	DET
bam-7218	1059	22	formation	formation	NOUN
bam-7218	1059	23	of	of	ADP
bam-7218	1059	24	protein	protein	NOUN
bam-7218	1059	25	aggregates	aggregate	NOUN
bam-7218	1059	26	which	which	PRON
bam-7218	1059	27	could	could	AUX
bam-7218	1059	28	be	be	AUX
bam-7218	1059	29	confirmed	confirm	VERB
bam-7218	1059	30	via	via	ADP
bam-7218	1059	31	cars	car	NOUN
bam-7218	1059	32	microscopy	microscopy	VERB
bam-7218	1059	33	.	.	PUNCT
bam-7218	1060	1	hence	hence	ADV
bam-7218	1060	2	,	,	PUNCT
bam-7218	1060	3	our	our	PRON
bam-7218	1060	4	combined	combine	VERB
bam-7218	1060	5	data	data	NOUN
bam-7218	1060	6	classify	classify	VERB
bam-7218	1060	7	(	(	PUNCT
bam-7218	1060	8	p.p104l	p.p104l	PROPN
bam-7218	1060	9	)	)	PUNCT
bam-7218	1060	10	caveolinopathy	caveolinopathy	ADJ
bam-7218	1060	11	as	as	ADP
bam-7218	1060	12	an	an	DET
bam-7218	1060	13	acquired	acquire	VERB
bam-7218	1060	14	protein	protein	NOUN
bam-7218	1060	15	folding	fold	VERB
bam-7218	1060	16	disease	disease	NOUN
bam-7218	1060	17	with	with	ADP
bam-7218	1060	18	sarcolemmal	sarcolemmal	ADJ
bam-7218	1060	19	affection	affection	NOUN
bam-7218	1060	20	and	and	CCONJ
bam-7218	1060	21	thus	thus	ADV
bam-7218	1060	22	expand	expand	VERB
bam-7218	1060	23	the	the	DET
bam-7218	1060	24	pathophysiological	pathophysiological	ADJ
bam-7218	1060	25	knowledge	knowledge	NOUN
bam-7218	1060	26	of	of	ADP
bam-7218	1060	27	this	this	DET
bam-7218	1060	28	disorder	disorder	NOUN
bam-7218	1060	29	,	,	PUNCT
bam-7218	1060	30	an	an	DET
bam-7218	1060	31	important	important	ADJ
bam-7218	1060	32	aspect	aspect	NOUN
bam-7218	1060	33	in	in	ADP
bam-7218	1060	34	the	the	DET
bam-7218	1060	35	therapeutic	therapeutic	ADJ
bam-7218	1060	36	management	management	NOUN
bam-7218	1060	37	of	of	ADP
bam-7218	1060	38	cav3	cav3	ADJ
bam-7218	1060	39	-	-	PUNCT
bam-7218	1060	40	patients	patient	NOUN
bam-7218	1060	41	.	.	PUNCT
bam-7218	1061	1	p.21	p.21	NOUN
bam-7218	1061	2	extracellular	extracellular	ADJ
bam-7218	1061	3	vesicles	vesicle	NOUN
bam-7218	1061	4	released	release	VERB
bam-7218	1061	5	during	during	ADP
bam-7218	1061	6	myogenic	myogenic	ADJ
bam-7218	1061	7	differentiation	differentiation	NOUN
bam-7218	1061	8	trigger	trigger	NOUN
bam-7218	1061	9	changes	change	NOUN
bam-7218	1061	10	in	in	ADP
bam-7218	1061	11	macrophage	macrophage	ADJ
bam-7218	1061	12	phenotype	phenotype	NOUN
bam-7218	1061	13	michele	michele	PROPN
bam-7218	1061	14	guescini	guescini	PROPN
bam-7218	1061	15	,	,	PUNCT
bam-7218	1061	16	serena	serena	PROPN
bam-7218	1061	17	maggio	maggio	PROPN
bam-7218	1061	18	,	,	PUNCT
bam-7218	1061	19	paola	paola	PROPN
bam-7218	1061	20	ceccaroli	ceccaroli	PROPN
bam-7218	1061	21	,	,	PUNCT
bam-7218	1061	22	giosuè	giosuè	PROPN
bam-7218	1061	23	annibalini	annibalini	PROPN
bam-7218	1061	24	,	,	PUNCT
bam-7218	1061	25	vilberto	vilberto	PROPN
bam-7218	1061	26	stocchi	stocchi	PROPN
bam-7218	1061	27	dept	dept	PROPN
bam-7218	1061	28	of	of	ADP
bam-7218	1061	29	biomolecular	biomolecular	ADJ
bam-7218	1061	30	sciences	science	NOUN
bam-7218	1061	31	,	,	PUNCT
bam-7218	1061	32	university	university	NOUN
bam-7218	1061	33	of	of	ADP
bam-7218	1061	34	urbino	urbino	PROPN
bam-7218	1061	35	carlo	carlo	PROPN
bam-7218	1061	36	bo	bo	PROPN
bam-7218	1061	37	,	,	PUNCT
bam-7218	1061	38	italy	italy	PROPN
bam-7218	1061	39	.	.	PUNCT
bam-7218	1062	1	email	email	NOUN
bam-7218	1062	2	:	:	PUNCT
bam-7218	1062	3	michele.guescini@uniurb.it	michele.guescini@uniurb.it	NOUN
bam-7218	1062	4	skeletal	skeletal	ADJ
bam-7218	1062	5	muscle	muscle	NOUN
bam-7218	1062	6	is	be	AUX
bam-7218	1062	7	a	a	DET
bam-7218	1062	8	highly	highly	ADV
bam-7218	1062	9	plastic	plastic	ADJ
bam-7218	1062	10	tissue	tissue	NOUN
bam-7218	1062	11	able	able	ADJ
bam-7218	1062	12	to	to	PART
bam-7218	1062	13	adapt	adapt	VERB
bam-7218	1062	14	to	to	ADP
bam-7218	1062	15	different	different	ADJ
bam-7218	1062	16	stresses	stress	NOUN
bam-7218	1062	17	,	,	PUNCT
bam-7218	1062	18	in	in	ADP
bam-7218	1062	19	part	part	NOUN
bam-7218	1062	20	due	due	ADP
bam-7218	1062	21	to	to	ADP
bam-7218	1062	22	its	its	PRON
bam-7218	1062	23	remarkable	remarkable	ADJ
bam-7218	1062	24	regenerative	regenerative	ADJ
bam-7218	1062	25	capacity	capacity	NOUN
bam-7218	1062	26	.	.	PUNCT
bam-7218	1063	1	recently	recently	ADV
bam-7218	1063	2	,	,	PUNCT
bam-7218	1063	3	it	it	PRON
bam-7218	1063	4	has	have	AUX
bam-7218	1063	5	been	be	AUX
bam-7218	1063	6	found	find	VERB
bam-7218	1063	7	that	that	SCONJ
bam-7218	1063	8	myoblasts	myoblast	NOUN
bam-7218	1063	9	and	and	CCONJ
bam-7218	1063	10	myotubes	myotube	NOUN
bam-7218	1063	11	release	release	VERB
bam-7218	1063	12	exosomes	exosome	NOUN
bam-7218	1063	13	and	and	CCONJ
bam-7218	1063	14	exosome	exosome	NOUN
bam-7218	1063	15	-	-	PUNCT
bam-7218	1063	16	like	like	ADJ
bam-7218	1063	17	vesicles	vesicle	NOUN
bam-7218	1063	18	in	in	ADP
bam-7218	1063	19	the	the	DET
bam-7218	1063	20	extracellular	extracellular	ADJ
bam-7218	1063	21	environment	environment	NOUN
bam-7218	1063	22	during	during	ADP
bam-7218	1063	23	myogenic	myogenic	ADJ
bam-7218	1063	24	differentiation	differentiation	NOUN
bam-7218	1063	25	.	.	PUNCT
bam-7218	1064	1	within	within	ADP
bam-7218	1064	2	the	the	DET
bam-7218	1064	3	satellite	satellite	NOUN
bam-7218	1064	4	cell	cell	NOUN
bam-7218	1064	5	niche	niche	NOUN
bam-7218	1064	6	,	,	PUNCT
bam-7218	1064	7	muscle	muscle	NOUN
bam-7218	1064	8	stem	stem	NOUN
bam-7218	1064	9	cells	cell	NOUN
bam-7218	1064	10	exchange	exchange	NOUN
bam-7218	1064	11	signals	signal	NOUN
bam-7218	1064	12	with	with	ADP
bam-7218	1064	13	other	other	ADJ
bam-7218	1064	14	cell	cell	NOUN
bam-7218	1064	15	types	type	NOUN
bam-7218	1064	16	,	,	PUNCT
bam-7218	1064	17	and	and	CCONJ
bam-7218	1064	18	among	among	ADP
bam-7218	1064	19	these	these	PRON
bam-7218	1064	20	,	,	PUNCT
bam-7218	1064	21	complex	complex	ADJ
bam-7218	1064	22	interactions	interaction	NOUN
bam-7218	1064	23	between	between	ADP
bam-7218	1064	24	skeletal	skeletal	ADJ
bam-7218	1064	25	muscle	muscle	NOUN
bam-7218	1064	26	and	and	CCONJ
bam-7218	1064	27	the	the	DET
bam-7218	1064	28	immune	immune	ADJ
bam-7218	1064	29	system	system	NOUN
bam-7218	1064	30	have	have	AUX
bam-7218	1064	31	been	be	AUX
bam-7218	1064	32	reported	report	VERB
bam-7218	1064	33	.	.	PUNCT
bam-7218	1065	1	the	the	DET
bam-7218	1065	2	aim	aim	NOUN
bam-7218	1065	3	of	of	ADP
bam-7218	1065	4	this	this	DET
bam-7218	1065	5	study	study	NOUN
bam-7218	1065	6	was	be	AUX
bam-7218	1065	7	to	to	PART
bam-7218	1065	8	ask	ask	VERB
bam-7218	1065	9	whether	whether	SCONJ
bam-7218	1065	10	evs	evs	NOUN
bam-7218	1065	11	(	(	PUNCT
bam-7218	1065	12	extracellular	extracellular	ADJ
bam-7218	1065	13	vescicles	vescicle	NOUN
bam-7218	1065	14	)	)	PUNCT
bam-7218	1065	15	released	release	VERB
bam-7218	1065	16	by	by	ADP
bam-7218	1065	17	differentiating	differentiate	VERB
bam-7218	1065	18	myocytes	myocyte	NOUN
bam-7218	1065	19	can	can	AUX
bam-7218	1065	20	mediate	mediate	VERB
bam-7218	1065	21	cell	cell	NOUN
bam-7218	1065	22	-	-	PUNCT
bam-7218	1065	23	communication	communication	NOUN
bam-7218	1065	24	between	between	ADP
bam-7218	1065	25	muscle	muscle	NOUN
bam-7218	1065	26	cells	cell	NOUN
bam-7218	1065	27	and	and	CCONJ
bam-7218	1065	28	macrophages	macrophage	NOUN
bam-7218	1065	29	,	,	PUNCT
bam-7218	1065	30	one	one	NUM
bam-7218	1065	31	of	of	ADP
bam-7218	1065	32	the	the	DET
bam-7218	1065	33	key	key	ADJ
bam-7218	1065	34	actors	actor	NOUN
bam-7218	1065	35	of	of	ADP
bam-7218	1065	36	muscle	muscle	NOUN
bam-7218	1065	37	remodelling	remodelling	NOUN
bam-7218	1065	38	.	.	PUNCT
bam-7218	1066	1	to	to	ADP
bam-7218	1066	2	this	this	DET
bam-7218	1066	3	end	end	NOUN
bam-7218	1066	4	,	,	PUNCT
bam-7218	1066	5	raw	raw	ADJ
bam-7218	1066	6	264.7	264.7	NUM
bam-7218	1066	7	cells	cell	NOUN
bam-7218	1066	8	(	(	PUNCT
bam-7218	1066	9	a	a	DET
bam-7218	1066	10	model	model	NOUN
bam-7218	1066	11	of	of	ADP
bam-7218	1066	12	macrophages	macrophage	NOUN
bam-7218	1066	13	)	)	PUNCT
bam-7218	1066	14	have	have	AUX
bam-7218	1066	15	been	be	AUX
bam-7218	1066	16	used	use	VERB
bam-7218	1066	17	as	as	ADP
bam-7218	1066	18	target	target	NOUN
bam-7218	1066	19	cells	cell	NOUN
bam-7218	1066	20	.	.	PUNCT
bam-7218	1067	1	myocytes	myocyte	NOUN
bam-7218	1067	2	undergoing	undergo	VERB
bam-7218	1067	3	myogenic	myogenic	ADJ
bam-7218	1067	4	differentiation	differentiation	NOUN
bam-7218	1067	5	are	be	AUX
bam-7218	1067	6	subjected	subject	VERB
bam-7218	1067	7	to	to	ADP
bam-7218	1067	8	deep	deep	ADJ
bam-7218	1067	9	structural	structural	ADJ
bam-7218	1067	10	rearrangements	rearrangement	NOUN
bam-7218	1067	11	,	,	PUNCT
bam-7218	1067	12	so	so	SCONJ
bam-7218	1067	13	that	that	SCONJ
bam-7218	1067	14	a	a	DET
bam-7218	1067	15	complex	complex	ADJ
bam-7218	1067	16	mixture	mixture	NOUN
bam-7218	1067	17	of	of	ADP
bam-7218	1067	18	evs	evs	NOUN
bam-7218	1067	19	(	(	PUNCT
bam-7218	1067	20	comprising	comprise	VERB
bam-7218	1067	21	exosomes	exosome	NOUN
bam-7218	1067	22	and	and	CCONJ
bam-7218	1067	23	shedding	shed	VERB
bam-7218	1067	24	microvesicles	microvesicle	NOUN
bam-7218	1067	25	)	)	PUNCT
bam-7218	1067	26	and	and	CCONJ
bam-7218	1067	27	cellular	cellular	ADJ
bam-7218	1067	28	membrane	membrane	NOUN
bam-7218	1067	29	fragments	fragment	NOUN
bam-7218	1067	30	may	may	AUX
bam-7218	1067	31	be	be	AUX
bam-7218	1067	32	released	release	VERB
bam-7218	1067	33	in	in	ADP
bam-7218	1067	34	the	the	DET
bam-7218	1067	35	extracellular	extracellular	ADJ
bam-7218	1067	36	environment	environment	NOUN
bam-7218	1067	37	.	.	PUNCT
bam-7218	1068	1	a	a	DET
bam-7218	1068	2	serial	serial	ADJ
bam-7218	1068	3	ultracentrifugation	ultracentrifugation	NOUN
bam-7218	1068	4	protocol	protocol	NOUN
bam-7218	1068	5	was	be	AUX
bam-7218	1068	6	specifically	specifically	ADV
bam-7218	1068	7	adjusted	adjust	VERB
bam-7218	1068	8	to	to	PART
bam-7218	1068	9	remove	remove	VERB
bam-7218	1068	10	cellular	cellular	ADJ
bam-7218	1068	11	debris	debris	NOUN
bam-7218	1068	12	and	and	CCONJ
bam-7218	1068	13	isolate	isolate	VERB
bam-7218	1068	14	shedding	shed	VERB
bam-7218	1068	15	microvesicles	microvesicle	NOUN
bam-7218	1068	16	and	and	CCONJ
bam-7218	1068	17	exosomes	exosome	NOUN
bam-7218	1068	18	.	.	PUNCT
bam-7218	1069	1	the	the	DET
bam-7218	1069	2	evs	evs	NOUN
bam-7218	1069	3	collected	collect	VERB
bam-7218	1069	4	during	during	ADP
bam-7218	1069	5	myogenic	myogenic	ADJ
bam-7218	1069	6	differentiation	differentiation	NOUN
bam-7218	1069	7	process	process	NOUN
bam-7218	1069	8	were	be	AUX
bam-7218	1069	9	characterized	characterize	VERB
bam-7218	1069	10	using	use	VERB
bam-7218	1069	11	tem	tem	PROPN
bam-7218	1069	12	,	,	PUNCT
bam-7218	1069	13	western	western	ADJ
bam-7218	1069	14	blot	blot	NOUN
bam-7218	1069	15	,	,	PUNCT
bam-7218	1069	16	density	density	NOUN
bam-7218	1069	17	gradient	gradient	NOUN
bam-7218	1069	18	and	and	CCONJ
bam-7218	1069	19	real	real	ADJ
bam-7218	1069	20	-	-	PUNCT
bam-7218	1069	21	time	time	NOUN
bam-7218	1069	22	pcr	pcr	NOUN
bam-7218	1069	23	analyses	analysis	NOUN
bam-7218	1069	24	and	and	CCONJ
bam-7218	1069	25	used	use	VERB
bam-7218	1069	26	to	to	PART
bam-7218	1069	27	treat	treat	VERB
bam-7218	1069	28	raw	raw	ADJ
bam-7218	1069	29	264.7	264.7	NUM
bam-7218	1069	30	cells	cell	NOUN
bam-7218	1069	31	.	.	PUNCT
bam-7218	1070	1	gene	gene	NOUN
bam-7218	1070	2	expression	expression	NOUN
bam-7218	1070	3	analysis	analysis	NOUN
bam-7218	1070	4	performed	perform	VERB
bam-7218	1070	5	24	24	NUM
bam-7218	1070	6	h	h	NOUN
bam-7218	1070	7	after	after	SCONJ
bam-7218	1070	8	treatment	treatment	NOUN
bam-7218	1070	9	highlighted	highlight	VERB
bam-7218	1070	10	a	a	DET
bam-7218	1070	11	significant	significant	ADJ
bam-7218	1070	12	up	up	NOUN
bam-7218	1070	13	-	-	PUNCT
bam-7218	1070	14	regulation	regulation	NOUN
bam-7218	1070	15	of	of	ADP
bam-7218	1070	16	il-6	il-6	NOUN
bam-7218	1070	17	and	and	CCONJ
bam-7218	1070	18	il-10	il-10	PRON
bam-7218	1070	19	,	,	PUNCT
bam-7218	1070	20	two	two	NUM
bam-7218	1070	21	cytokines	cytokine	NOUN
bam-7218	1070	22	involved	involve	VERB
bam-7218	1070	23	in	in	ADP
bam-7218	1070	24	muscle	muscle	NOUN
bam-7218	1070	25	differentiation	differentiation	NOUN
bam-7218	1070	26	and	and	CCONJ
bam-7218	1070	27	anti	anti	ADJ
bam-7218	1070	28	-	-	ADJ
bam-7218	1070	29	inflammatory	inflammatory	ADJ
bam-7218	1070	30	process	process	NOUN
bam-7218	1070	31	,	,	PUNCT
bam-7218	1070	32	respectively	respectively	ADV
bam-7218	1070	33	,	,	PUNCT
bam-7218	1070	34	but	but	CCONJ
bam-7218	1070	35	not	not	PART
bam-7218	1070	36	of	of	ADP
bam-7218	1070	37	tnf	tnf	PROPN
bam-7218	1070	38	-	-	PUNCT
bam-7218	1070	39	alpha	alpha	NOUN
bam-7218	1070	40	(	(	PUNCT
bam-7218	1070	41	a	a	DET
bam-7218	1070	42	proinflammatory	proinflammatory	ADJ
bam-7218	1070	43	cytokine	cytokine	NOUN
bam-7218	1070	44	)	)	PUNCT
bam-7218	1070	45	.	.	PUNCT
bam-7218	1071	1	il-6	il-6	NOUN
bam-7218	1071	2	stimulates	stimulate	VERB
bam-7218	1071	3	the	the	DET
bam-7218	1071	4	production	production	NOUN
bam-7218	1071	5	of	of	ADP
bam-7218	1071	6	the	the	DET
bam-7218	1071	7	classical	classical	ADJ
bam-7218	1071	8	anti	anti	ADJ
bam-7218	1071	9	-	-	ADJ
bam-7218	1071	10	inflammatory	inflammatory	ADJ
bam-7218	1071	11	cytokines	cytokine	NOUN
bam-7218	1071	12	il-1ra	il-1ra	ADJ
bam-7218	1071	13	and	and	CCONJ
bam-7218	1071	14	il-10	il-10	PRON
bam-7218	1071	15	,	,	PUNCT
bam-7218	1071	16	moreover	moreover	ADV
bam-7218	1071	17	it	it	PRON
bam-7218	1071	18	has	have	AUX
bam-7218	1071	19	been	be	AUX
bam-7218	1071	20	reported	report	VERB
bam-7218	1071	21	that	that	SCONJ
bam-7218	1071	22	il-10	il-10	PRON
bam-7218	1071	23	plays	play	VERB
bam-7218	1071	24	a	a	DET
bam-7218	1071	25	central	central	ADJ
bam-7218	1071	26	role	role	NOUN
bam-7218	1071	27	in	in	ADP
bam-7218	1071	28	regulating	regulate	VERB
bam-7218	1071	29	the	the	DET
bam-7218	1071	30	switch	switch	NOUN
bam-7218	1071	31	of	of	ADP
bam-7218	1071	32	muscle	muscle	NOUN
bam-7218	1071	33	macrophages	macrophage	NOUN
bam-7218	1071	34	from	from	ADP
bam-7218	1071	35	a	a	DET
bam-7218	1071	36	m1	m1	NOUN
bam-7218	1071	37	to	to	ADP
bam-7218	1071	38	m2	m2	PROPN
bam-7218	1071	39	phenotype	phenotype	NOUN
bam-7218	1071	40	in	in	ADP
bam-7218	1071	41	injured	injure	VERB
bam-7218	1071	42	muscle	muscle	NOUN
bam-7218	1071	43	in	in	ADP
bam-7218	1071	44	vivo	vivo	NOUN
bam-7218	1071	45	.	.	PUNCT
bam-7218	1072	1	collectivelly	collectivelly	ADV
bam-7218	1072	2	,	,	PUNCT
bam-7218	1072	3	these	these	DET
bam-7218	1072	4	data	datum	NOUN
bam-7218	1072	5	suggest	suggest	VERB
bam-7218	1072	6	that	that	SCONJ
bam-7218	1072	7	evs	evs	NOUN
bam-7218	1072	8	could	could	AUX
bam-7218	1072	9	be	be	AUX
bam-7218	1072	10	involved	involve	VERB
bam-7218	1072	11	in	in	ADP
bam-7218	1072	12	the	the	DET
bam-7218	1072	13	regulation	regulation	NOUN
bam-7218	1072	14	of	of	ADP
bam-7218	1072	15	normal	normal	ADJ
bam-7218	1072	16	growth	growth	NOUN
bam-7218	1072	17	and	and	CCONJ
bam-7218	1072	18	regeneration	regeneration	NOUN
bam-7218	1072	19	of	of	ADP
bam-7218	1072	20	muscle	muscle	NOUN
bam-7218	1072	21	.	.	PUNCT
bam-7218	1073	1	supported	support	VERB
bam-7218	1073	2	by	by	ADP
bam-7218	1073	3	:	:	PUNCT
bam-7218	1073	4	italian	italian	ADJ
bam-7218	1073	5	ministry	ministry	PROPN
bam-7218	1073	6	of	of	ADP
bam-7218	1073	7	health	health	PROPN
bam-7218	1073	8	:	:	PUNCT
bam-7218	1073	9	gr-2011	gr-2011	PROPN
bam-7218	1073	10	-	-	PUNCT
bam-7218	1073	11	02350264	02350264	NUM
bam-7218	1073	12	to	to	ADP
bam-7218	1073	13	mg	mg	PROPN
bam-7218	1073	14	.	.	PUNCT
bam-7218	1074	1	p.22	p.22	PROPN
bam-7218	1074	2	pericyte	pericyte	NOUN
bam-7218	1074	3	in	in	ADP
bam-7218	1074	4	the	the	DET
bam-7218	1074	5	muscle	muscle	NOUN
bam-7218	1074	6	satellite	satellite	NOUN
bam-7218	1074	7	cell	cell	NOUN
bam-7218	1074	8	niche	niche	NOUN
bam-7218	1074	9	:	:	PUNCT
bam-7218	1074	10	a	a	DET
bam-7218	1074	11	key	key	ADJ
bam-7218	1074	12	player	player	NOUN
bam-7218	1074	13	maintaining	maintain	VERB
bam-7218	1074	14	the	the	DET
bam-7218	1074	15	steady	steady	ADJ
bam-7218	1074	16	state	state	NOUN
bam-7218	1074	17	and	and	CCONJ
bam-7218	1074	18	helping	help	VERB
bam-7218	1074	19	recovery	recovery	NOUN
bam-7218	1074	20	.	.	PUNCT
bam-7218	1075	1	koumaiha	koumaiha	PROPN
bam-7218	1075	2	zeynab	zeynab	PROPN
bam-7218	1075	3	(	(	PUNCT
bam-7218	1075	4	a	a	X
bam-7218	1075	5	)	)	PUNCT
bam-7218	1075	6	,	,	PUNCT
bam-7218	1075	7	baptiste	baptiste	NOUN
bam-7218	1075	8	périou	périou	NOUN
bam-7218	1075	9	(	(	PUNCT
bam-7218	1075	10	b	b	NOUN
bam-7218	1075	11	)	)	PUNCT
bam-7218	1075	12	,	,	PUNCT
bam-7218	1075	13	muriel	muriel	PROPN
bam-7218	1075	14	rigolet	rigolet	PROPN
bam-7218	1075	15	(	(	PUNCT
bam-7218	1075	16	b	b	NOUN
bam-7218	1075	17	)	)	PUNCT
bam-7218	1075	18	,	,	PUNCT
bam-7218	1075	19	frederic	frederic	PROPN
bam-7218	1075	20	relaix	relaix	PROPN
bam-7218	1075	21	(	(	PUNCT
bam-7218	1075	22	a	a	DET
bam-7218	1075	23	,	,	PUNCT
bam-7218	1075	24	c	c	NOUN
bam-7218	1075	25	)	)	PUNCT
bam-7218	1075	26	,	,	PUNCT
bam-7218	1075	27	romain	romain	PROPN
bam-7218	1075	28	gherardi	gherardi	PROPN
bam-7218	1075	29	(	(	PUNCT
bam-7218	1075	30	b	b	NOUN
bam-7218	1075	31	,	,	PUNCT
bam-7218	1075	32	c	c	NOUN
bam-7218	1075	33	)	)	PUNCT
bam-7218	1075	34	,	,	PUNCT
bam-7218	1075	35	peggy	peggy	PROPN
bam-7218	1075	36	lafuste	lafuste	PROPN
bam-7218	1075	37	(	(	PUNCT
bam-7218	1075	38	a	a	NOUN
bam-7218	1075	39	)	)	PUNCT
bam-7218	1075	40	(	(	PUNCT
bam-7218	1075	41	a	a	X
bam-7218	1075	42	)	)	PUNCT
bam-7218	1075	43	inserm	inserm	NOUN
bam-7218	1075	44	imrb	imrb	PROPN
bam-7218	1075	45	u955	u955	NUM
bam-7218	1075	46	,	,	PUNCT
bam-7218	1075	47	team	team	NOUN
bam-7218	1075	48	10	10	NUM
bam-7218	1075	49	group	group	NOUN
bam-7218	1075	50	1	1	NUM
bam-7218	1075	51	–	–	PUNCT
bam-7218	1075	52	(	(	PUNCT
bam-7218	1075	53	b	b	NOUN
bam-7218	1075	54	)	)	PUNCT
bam-7218	1075	55	inserm	inserm	NOUN
bam-7218	1075	56	imrb	imrb	NOUN
bam-7218	1075	57	u955	u955	NUM
bam-7218	1075	58	,	,	PUNCT
bam-7218	1075	59	team	team	NOUN
bam-7218	1075	60	10	10	NUM
bam-7218	1075	61	group	group	NOUN
bam-7218	1075	62	2	2	NUM
bam-7218	1075	63	–	–	PUNCT
bam-7218	1075	64	(	(	PUNCT
bam-7218	1075	65	c	c	X
bam-7218	1075	66	)	)	PUNCT
bam-7218	1075	67	henri	henri	PROPN
bam-7218	1075	68	mondor	mondor	PROPN
bam-7218	1075	69	hospital	hospital	PROPN
bam-7218	1075	70	,	,	PUNCT
bam-7218	1075	71	dept	dept	NOUN
bam-7218	1075	72	of	of	ADP
bam-7218	1075	73	pathology	pathology	PROPN
bam-7218	1075	74	,	,	PUNCT
bam-7218	1075	75	university	university	PROPN
bam-7218	1075	76	of	of	ADP
bam-7218	1075	77	paris	paris	PROPN
bam-7218	1075	78	-	-	PUNCT
bam-7218	1075	79	est	est	PROPN
bam-7218	1075	80	creteil	creteil	PROPN
bam-7218	1075	81	,	,	PUNCT
bam-7218	1075	82	france	france	PROPN
bam-7218	1075	83	.	.	PUNCT
bam-7218	1076	1	email	email	NOUN
bam-7218	1076	2	:	:	PUNCT
bam-7218	1076	3	peggy.lafuste@inserm.fr	peggy.lafuste@inserm.fr	NOUN
bam-7218	1076	4	muscle	muscle	NOUN
bam-7218	1076	5	growth	growth	NOUN
bam-7218	1076	6	and	and	CCONJ
bam-7218	1076	7	regeneration	regeneration	NOUN
bam-7218	1076	8	following	follow	VERB
bam-7218	1076	9	injury	injury	NOUN
bam-7218	1076	10	,	,	PUNCT
bam-7218	1076	11	is	be	AUX
bam-7218	1076	12	regulated	regulate	VERB
bam-7218	1076	13	by	by	ADP
bam-7218	1076	14	the	the	DET
bam-7218	1076	15	myogenic	myogenic	ADJ
bam-7218	1076	16	stem	stem	NOUN
bam-7218	1076	17	cells	cell	NOUN
bam-7218	1076	18	,	,	PUNCT
bam-7218	1076	19	called	call	VERB
bam-7218	1076	20	satellite	satellite	NOUN
bam-7218	1076	21	cells	cell	NOUN
bam-7218	1076	22	.	.	PUNCT
bam-7218	1077	1	the	the	DET
bam-7218	1077	2	satellite	satellite	NOUN
bam-7218	1077	3	cells	cell	NOUN
bam-7218	1077	4	are	be	AUX
bam-7218	1077	5	located	locate	VERB
bam-7218	1077	6	beneath	beneath	ADP
bam-7218	1077	7	myofiber	myofiber	PROPN
bam-7218	1077	8	mailto:jandresgonzalezc@gmail.com	mailto:jandresgonzalezc@gmail.com	PROPN
bam-7218	1078	1	mailto:michele.guescini@uniurb.it	mailto:michele.guescini@uniurb.it	PROPN
bam-7218	1078	2	mailto:peggy.lafuste@inserm.fr	mailto:peggy.lafuste@inserm.fr	PROPN
bam-7218	1078	3	14	14	NUM
bam-7218	1078	4	th	th	NOUN
bam-7218	1078	5	iiim	iiim	NOUN
bam-7218	1078	6	meeting	meeting	NOUN
bam-7218	1078	7	,	,	PUNCT
bam-7218	1078	8	assisi	assisi	PROPN
bam-7218	1078	9	,	,	PUNCT
bam-7218	1078	10	italy	italy	PROPN
bam-7218	1078	11	october	october	PROPN
bam-7218	1078	12	12	12	NUM
bam-7218	1078	13	-	-	SYM
bam-7218	1078	14	15	15	NUM
bam-7218	1078	15	2017	2017	NUM
bam-7218	1078	16	eur	eur	PROPN
bam-7218	1078	17	j	j	PROPN
bam-7218	1078	18	transl	transl	PROPN
bam-7218	1078	19	myol	myol	ADV
bam-7218	1078	20	27	27	NUM
bam-7218	1078	21	(	(	PUNCT
bam-7218	1078	22	4	4	NUM
bam-7218	1078	23	):	):	SYM
bam-7218	1078	24	185	185	NUM
bam-7218	1078	25	-	-	SYM
bam-7218	1078	26	224	224	NUM
bam-7218	1078	27	218	218	NUM
bam-7218	1078	28	basement	basement	NOUN
bam-7218	1078	29	membranes	membrane	NOUN
bam-7218	1078	30	and	and	CCONJ
bam-7218	1078	31	closely	closely	ADV
bam-7218	1078	32	associated	associate	VERB
bam-7218	1078	33	with	with	ADP
bam-7218	1078	34	capillary	capillary	ADJ
bam-7218	1078	35	endothelial	endothelial	ADJ
bam-7218	1078	36	cells	cell	NOUN
bam-7218	1078	37	.	.	PUNCT
bam-7218	1079	1	we	we	PRON
bam-7218	1079	2	previously	previously	ADV
bam-7218	1079	3	observed	observe	VERB
bam-7218	1079	4	that	that	SCONJ
bam-7218	1079	5	90	90	NUM
bam-7218	1079	6	%	%	NOUN
bam-7218	1079	7	of	of	ADP
bam-7218	1079	8	capillaries	capillary	NOUN
bam-7218	1079	9	were	be	AUX
bam-7218	1079	10	associated	associate	VERB
bam-7218	1079	11	with	with	ADP
bam-7218	1079	12	pericytes	pericyte	NOUN
bam-7218	1079	13	in	in	ADP
bam-7218	1079	14	adult	adult	NOUN
bam-7218	1079	15	mouse	mouse	NOUN
bam-7218	1079	16	and	and	CCONJ
bam-7218	1079	17	human	human	ADJ
bam-7218	1079	18	muscle	muscle	NOUN
bam-7218	1079	19	.	.	PUNCT
bam-7218	1080	1	we	we	PRON
bam-7218	1080	2	also	also	ADV
bam-7218	1080	3	have	have	AUX
bam-7218	1080	4	shown	show	VERB
bam-7218	1080	5	during	during	ADP
bam-7218	1080	6	post	post	ADJ
bam-7218	1080	7	-	-	ADJ
bam-7218	1080	8	natal	natal	ADJ
bam-7218	1080	9	growth	growth	NOUN
bam-7218	1080	10	that	that	PRON
bam-7218	1080	11	,	,	PUNCT
bam-7218	1080	12	by	by	ADP
bam-7218	1080	13	promoting	promote	VERB
bam-7218	1080	14	post	post	ADJ
bam-7218	1080	15	-	-	ADJ
bam-7218	1080	16	natal	natal	ADJ
bam-7218	1080	17	myogenesis	myogenesis	NOUN
bam-7218	1080	18	through	through	ADP
bam-7218	1080	19	insulin	insulin	NOUN
bam-7218	1080	20	like	like	ADP
bam-7218	1080	21	-	-	PUNCT
bam-7218	1080	22	growth	growth	NOUN
bam-7218	1080	23	factor	factor	NOUN
bam-7218	1080	24	1	1	NUM
bam-7218	1080	25	and	and	CCONJ
bam-7218	1080	26	stem	stem	NOUN
bam-7218	1080	27	cell	cell	NOUN
bam-7218	1080	28	quiescence	quiescence	NOUN
bam-7218	1080	29	through	through	ADP
bam-7218	1080	30	angiopoietin-1	angiopoietin-1	PROPN
bam-7218	1080	31	,	,	PUNCT
bam-7218	1080	32	pericytes	pericyte	NOUN
bam-7218	1080	33	play	play	VERB
bam-7218	1080	34	a	a	DET
bam-7218	1080	35	key	key	ADJ
bam-7218	1080	36	role	role	NOUN
bam-7218	1080	37	in	in	ADP
bam-7218	1080	38	the	the	DET
bam-7218	1080	39	microvascular	microvascular	ADJ
bam-7218	1080	40	niche	niche	NOUN
bam-7218	1080	41	of	of	ADP
bam-7218	1080	42	satellite	satellite	NOUN
bam-7218	1080	43	cells	cell	NOUN
bam-7218	1080	44	.	.	PUNCT
bam-7218	1081	1	consistently	consistently	ADV
bam-7218	1081	2	,	,	PUNCT
bam-7218	1081	3	here	here	ADV
bam-7218	1081	4	we	we	PRON
bam-7218	1081	5	show	show	VERB
bam-7218	1081	6	that	that	SCONJ
bam-7218	1081	7	in	in	ADP
bam-7218	1081	8	a	a	DET
bam-7218	1081	9	mouse	mouse	NOUN
bam-7218	1081	10	model	model	NOUN
bam-7218	1081	11	of	of	ADP
bam-7218	1081	12	muscle	muscle	NOUN
bam-7218	1081	13	pericytes	pericyte	NOUN
bam-7218	1081	14	depletion	depletion	NOUN
bam-7218	1081	15	,	,	PUNCT
bam-7218	1081	16	the	the	DET
bam-7218	1081	17	loss	loss	NOUN
bam-7218	1081	18	of	of	ADP
bam-7218	1081	19	the	the	DET
bam-7218	1081	20	perivascular	perivascular	ADJ
bam-7218	1081	21	cells	cell	NOUN
bam-7218	1081	22	induces	induce	VERB
bam-7218	1081	23	a	a	DET
bam-7218	1081	24	spontaneous	spontaneous	ADJ
bam-7218	1081	25	necrosis	necrosis	NOUN
bam-7218	1081	26	of	of	ADP
bam-7218	1081	27	the	the	DET
bam-7218	1081	28	muscle	muscle	NOUN
bam-7218	1081	29	.	.	PUNCT
bam-7218	1082	1	we	we	PRON
bam-7218	1082	2	also	also	ADV
bam-7218	1082	3	observed	observe	VERB
bam-7218	1082	4	after	after	ADP
bam-7218	1082	5	induced	induce	VERB
bam-7218	1082	6	chemical	chemical	ADJ
bam-7218	1082	7	injury	injury	NOUN
bam-7218	1082	8	of	of	ADP
bam-7218	1082	9	the	the	DET
bam-7218	1082	10	muscle	muscle	NOUN
bam-7218	1082	11	in	in	ADP
bam-7218	1082	12	a	a	DET
bam-7218	1082	13	mouse	mouse	NOUN
bam-7218	1082	14	model	model	NOUN
bam-7218	1082	15	of	of	ADP
bam-7218	1082	16	depletion	depletion	NOUN
bam-7218	1082	17	of	of	ADP
bam-7218	1082	18	microvascular	microvascular	NOUN
bam-7218	1082	19	angiopoietin-1	angiopoietin-1	PROPN
bam-7218	1082	20	,	,	PUNCT
bam-7218	1082	21	a	a	DET
bam-7218	1082	22	delayed	delay	VERB
bam-7218	1082	23	regeneration	regeneration	NOUN
bam-7218	1082	24	process	process	NOUN
bam-7218	1082	25	associated	associate	VERB
bam-7218	1082	26	with	with	ADP
bam-7218	1082	27	type	type	NOUN
bam-7218	1082	28	2	2	NUM
bam-7218	1082	29	myofibers	myofiber	NOUN
bam-7218	1082	30	hypotrophy	hypotrophy	PROPN
bam-7218	1082	31	along	along	ADP
bam-7218	1082	32	with	with	ADP
bam-7218	1082	33	an	an	DET
bam-7218	1082	34	elevated	elevated	ADJ
bam-7218	1082	35	number	number	NOUN
bam-7218	1082	36	of	of	ADP
bam-7218	1082	37	remaining	remain	VERB
bam-7218	1082	38	cycling	cycling	NOUN
bam-7218	1082	39	pax7	pax7	NOUN
bam-7218	1082	40	+	+	CCONJ
bam-7218	1082	41	cells	cell	NOUN
bam-7218	1082	42	.	.	PUNCT
bam-7218	1083	1	in	in	ADP
bam-7218	1083	2	conclusion	conclusion	NOUN
bam-7218	1083	3	,	,	PUNCT
bam-7218	1083	4	pericytes	pericyte	NOUN
bam-7218	1083	5	associated	associate	VERB
bam-7218	1083	6	with	with	ADP
bam-7218	1083	7	endothelial	endothelial	ADJ
bam-7218	1083	8	cells	cell	NOUN
bam-7218	1083	9	are	be	AUX
bam-7218	1083	10	essential	essential	ADJ
bam-7218	1083	11	to	to	PART
bam-7218	1083	12	maintain	maintain	VERB
bam-7218	1083	13	adult	adult	NOUN
bam-7218	1083	14	muscle	muscle	NOUN
bam-7218	1083	15	homeostasis	homeostasis	NOUN
bam-7218	1083	16	and	and	CCONJ
bam-7218	1083	17	exert	exert	VERB
bam-7218	1083	18	paracrine	paracrine	NOUN
bam-7218	1083	19	effects	effect	NOUN
bam-7218	1083	20	on	on	ADP
bam-7218	1083	21	adjacent	adjacent	ADJ
bam-7218	1083	22	myogenic	myogenic	ADJ
bam-7218	1083	23	cells	cell	NOUN
bam-7218	1083	24	during	during	ADP
bam-7218	1083	25	muscle	muscle	NOUN
bam-7218	1083	26	repair	repair	NOUN
bam-7218	1083	27	in	in	ADP
bam-7218	1083	28	adulthood	adulthood	NOUN
bam-7218	1083	29	.	.	PUNCT
bam-7218	1084	1	p.23	p.23	AUX
bam-7218	1084	2	silencing	silence	VERB
bam-7218	1084	3	nfix	nfix	NOUN
bam-7218	1084	4	rescues	rescue	VERB
bam-7218	1084	5	muscular	muscular	ADJ
bam-7218	1084	6	dystrophy	dystrophy	NOUN
bam-7218	1084	7	by	by	ADP
bam-7218	1084	8	delaying	delay	VERB
bam-7218	1084	9	muscle	muscle	NOUN
bam-7218	1084	10	regeneration	regeneration	NOUN
bam-7218	1084	11	giuliana	giuliana	PROPN
bam-7218	1084	12	rossi	rossi	PROPN
bam-7218	1084	13	(	(	PUNCT
bam-7218	1084	14	a	a	NOUN
bam-7218	1084	15	)	)	PUNCT
bam-7218	1084	16	,	,	PUNCT
bam-7218	1084	17	chiara	chiara	X
bam-7218	1084	18	bonfanti	bonfanti	PROPN
bam-7218	1084	19	(	(	PUNCT
bam-7218	1084	20	a	a	NOUN
bam-7218	1084	21	)	)	PUNCT
bam-7218	1084	22	,	,	PUNCT
bam-7218	1084	23	stefania	stefania	PROPN
bam-7218	1084	24	antonini	antonini	PROPN
bam-7218	1084	25	(	(	PUNCT
bam-7218	1084	26	a	a	NOUN
bam-7218	1084	27	)	)	PUNCT
bam-7218	1084	28	,	,	PUNCT
bam-7218	1084	29	mattia	mattia	NOUN
bam-7218	1084	30	bastoni	bastoni	NOUN
bam-7218	1084	31	(	(	PUNCT
bam-7218	1084	32	a	a	NOUN
bam-7218	1084	33	)	)	PUNCT
bam-7218	1084	34	,	,	PUNCT
bam-7218	1084	35	stefania	stefania	PROPN
bam-7218	1084	36	monteverde	monteverde	PROPN
bam-7218	1084	37	(	(	PUNCT
bam-7218	1084	38	a	a	NOUN
bam-7218	1084	39	)	)	PUNCT
bam-7218	1084	40	,	,	PUNCT
bam-7218	1084	41	anna	anna	NOUN
bam-7218	1084	42	innocenzi	innocenzi	NOUN
bam-7218	1084	43	(	(	PUNCT
bam-7218	1084	44	b	b	NOUN
bam-7218	1084	45	)	)	PUNCT
bam-7218	1084	46	,	,	PUNCT
bam-7218	1084	47	marielle	marielle	PROPN
bam-7218	1084	48	saclier	saclier	X
bam-7218	1084	49	(	(	PUNCT
bam-7218	1084	50	a	a	X
bam-7218	1084	51	)	)	PUNCT
bam-7218	1084	52	,	,	PUNCT
bam-7218	1084	53	valentina	valentina	PROPN
bam-7218	1084	54	taglietti	taglietti	PROPN
bam-7218	1084	55	(	(	PUNCT
bam-7218	1084	56	a	a	NOUN
bam-7218	1084	57	)	)	PUNCT
bam-7218	1084	58	,	,	PUNCT
bam-7218	1084	59	graziella	graziella	PROPN
bam-7218	1084	60	messina	messina	PROPN
bam-7218	1084	61	(	(	PUNCT
bam-7218	1084	62	a	a	PROPN
bam-7218	1084	63	)	)	PUNCT
bam-7218	1084	64	a	a	DET
bam-7218	1084	65	dept	dept	NOUN
bam-7218	1084	66	of	of	ADP
bam-7218	1084	67	biosciences	bioscience	NOUN
bam-7218	1084	68	,	,	PUNCT
bam-7218	1084	69	university	university	PROPN
bam-7218	1084	70	of	of	ADP
bam-7218	1084	71	milan	milan	PROPN
bam-7218	1084	72	,	,	PUNCT
bam-7218	1084	73	italy	italy	PROPN
bam-7218	1084	74	.	.	PUNCT
bam-7218	1085	1	b	b	PROPN
bam-7218	1085	2	division	division	NOUN
bam-7218	1085	3	of	of	ADP
bam-7218	1085	4	regenerative	regenerative	ADJ
bam-7218	1085	5	medicine	medicine	NOUN
bam-7218	1085	6	,	,	PUNCT
bam-7218	1085	7	stem	stem	NOUN
bam-7218	1085	8	cells	cell	NOUN
bam-7218	1085	9	and	and	CCONJ
bam-7218	1085	10	gene	gene	NOUN
bam-7218	1085	11	therapy	therapy	NOUN
bam-7218	1085	12	,	,	PUNCT
bam-7218	1085	13	san	san	PROPN
bam-7218	1085	14	raffaele	raffaele	PROPN
bam-7218	1085	15	scientific	scientific	PROPN
bam-7218	1085	16	institute	institute	PROPN
bam-7218	1085	17	,	,	PUNCT
bam-7218	1085	18	italy	italy	PROPN
bam-7218	1085	19	.	.	PUNCT
bam-7218	1086	1	email	email	NOUN
bam-7218	1086	2	:	:	PUNCT
bam-7218	1086	3	graziella.messina@unimi.it	graziella.messina@unimi.it	VERB
bam-7218	1086	4	muscular	muscular	ADJ
bam-7218	1086	5	dystrophies	dystrophy	NOUN
bam-7218	1086	6	are	be	AUX
bam-7218	1086	7	severe	severe	ADJ
bam-7218	1086	8	disorders	disorder	NOUN
bam-7218	1086	9	due	due	ADJ
bam-7218	1086	10	to	to	ADP
bam-7218	1086	11	mutations	mutation	NOUN
bam-7218	1086	12	in	in	ADP
bam-7218	1086	13	structural	structural	ADJ
bam-7218	1086	14	genes	gene	NOUN
bam-7218	1086	15	that	that	PRON
bam-7218	1086	16	cause	cause	VERB
bam-7218	1086	17	skeletal	skeletal	ADJ
bam-7218	1086	18	muscle	muscle	NOUN
bam-7218	1086	19	wasting	waste	VERB
bam-7218	1086	20	compromising	compromise	VERB
bam-7218	1086	21	patient	patient	ADJ
bam-7218	1086	22	mobility	mobility	NOUN
bam-7218	1086	23	and	and	CCONJ
bam-7218	1086	24	respiratory	respiratory	ADJ
bam-7218	1086	25	functions	function	NOUN
bam-7218	1086	26	.	.	PUNCT
bam-7218	1087	1	although	although	SCONJ
bam-7218	1087	2	previous	previous	ADJ
bam-7218	1087	3	works	work	NOUN
bam-7218	1087	4	suggested	suggest	VERB
bam-7218	1087	5	enhancing	enhance	VERB
bam-7218	1087	6	regeneration	regeneration	NOUN
bam-7218	1087	7	and	and	CCONJ
bam-7218	1087	8	muscle	muscle	NOUN
bam-7218	1087	9	mass	mass	NOUN
bam-7218	1087	10	as	as	ADP
bam-7218	1087	11	therapeutic	therapeutic	ADJ
bam-7218	1087	12	strategies	strategy	NOUN
bam-7218	1087	13	,	,	PUNCT
bam-7218	1087	14	these	these	PRON
bam-7218	1087	15	led	lead	VERB
bam-7218	1087	16	to	to	ADP
bam-7218	1087	17	no	no	DET
bam-7218	1087	18	long	long	ADJ
bam-7218	1087	19	-	-	PUNCT
bam-7218	1087	20	term	term	NOUN
bam-7218	1087	21	benefits	benefit	NOUN
bam-7218	1087	22	in	in	ADP
bam-7218	1087	23	humans	human	NOUN
bam-7218	1087	24	.	.	PUNCT
bam-7218	1088	1	here	here	ADV
bam-7218	1088	2	we	we	PRON
bam-7218	1088	3	propose	propose	VERB
bam-7218	1088	4	a	a	DET
bam-7218	1088	5	conceptually	conceptually	ADV
bam-7218	1088	6	new	new	ADJ
bam-7218	1088	7	idea	idea	NOUN
bam-7218	1088	8	based	base	VERB
bam-7218	1088	9	on	on	ADP
bam-7218	1088	10	making	make	VERB
bam-7218	1088	11	a	a	DET
bam-7218	1088	12	dystrophic	dystrophic	ADJ
bam-7218	1088	13	muscle	muscle	NOUN
bam-7218	1088	14	slower	slow	ADV
bam-7218	1088	15	in	in	ADP
bam-7218	1088	16	regeneration	regeneration	NOUN
bam-7218	1088	17	and	and	CCONJ
bam-7218	1088	18	more	more	ADV
bam-7218	1088	19	oxidative	oxidative	ADJ
bam-7218	1088	20	,	,	PUNCT
bam-7218	1088	21	by	by	ADP
bam-7218	1088	22	silencing	silence	VERB
bam-7218	1088	23	of	of	ADP
bam-7218	1088	24	the	the	DET
bam-7218	1088	25	transcription	transcription	NOUN
bam-7218	1088	26	factor	factor	NOUN
bam-7218	1088	27	nfix	nfix	NOUN
bam-7218	1088	28	.	.	PUNCT
bam-7218	1089	1	in	in	ADP
bam-7218	1089	2	different	different	ADJ
bam-7218	1089	3	forms	form	NOUN
bam-7218	1089	4	of	of	ADP
bam-7218	1089	5	muscular	muscular	ADJ
bam-7218	1089	6	dystrophy	dystrophy	NOUN
bam-7218	1089	7	,	,	PUNCT
bam-7218	1089	8	lack	lack	NOUN
bam-7218	1089	9	of	of	ADP
bam-7218	1089	10	nfix	nfix	NOUN
bam-7218	1089	11	rescues	rescue	VERB
bam-7218	1089	12	histopathological	histopathological	ADJ
bam-7218	1089	13	and	and	CCONJ
bam-7218	1089	14	functional	functional	ADJ
bam-7218	1089	15	hallmarks	hallmark	NOUN
bam-7218	1089	16	of	of	ADP
bam-7218	1089	17	dystrophic	dystrophic	ADJ
bam-7218	1089	18	muscle	muscle	NOUN
bam-7218	1089	19	.	.	PUNCT
bam-7218	1090	1	more	more	ADV
bam-7218	1090	2	importantly	importantly	ADV
bam-7218	1090	3	,	,	PUNCT
bam-7218	1090	4	silencing	silence	VERB
bam-7218	1090	5	nfix	nfix	NOUN
bam-7218	1090	6	in	in	ADP
bam-7218	1090	7	post	post	ADJ
bam-7218	1090	8	-	-	ADJ
bam-7218	1090	9	natal	natal	ADJ
bam-7218	1090	10	dystrophic	dystrophic	ADJ
bam-7218	1090	11	mice	mouse	NOUN
bam-7218	1090	12	,	,	PUNCT
bam-7218	1090	13	when	when	SCONJ
bam-7218	1090	14	the	the	DET
bam-7218	1090	15	first	first	ADJ
bam-7218	1090	16	signs	sign	NOUN
bam-7218	1090	17	of	of	ADP
bam-7218	1090	18	the	the	DET
bam-7218	1090	19	disease	disease	NOUN
bam-7218	1090	20	already	already	ADV
bam-7218	1090	21	occurred	occur	VERB
bam-7218	1090	22	,	,	PUNCT
bam-7218	1090	23	rescues	rescue	VERB
bam-7218	1090	24	the	the	DET
bam-7218	1090	25	pathology	pathology	NOUN
bam-7218	1090	26	.	.	PUNCT
bam-7218	1091	1	on	on	ADP
bam-7218	1091	2	the	the	DET
bam-7218	1091	3	contrary	contrary	NOUN
bam-7218	1091	4	,	,	PUNCT
bam-7218	1091	5	nfix	nfix	NOUN
bam-7218	1091	6	overexpression	overexpression	NOUN
bam-7218	1091	7	in	in	ADP
bam-7218	1091	8	dystrophic	dystrophic	ADJ
bam-7218	1091	9	muscles	muscle	NOUN
bam-7218	1091	10	pushes	push	VERB
bam-7218	1091	11	regeneration	regeneration	NOUN
bam-7218	1091	12	and	and	CCONJ
bam-7218	1091	13	markedly	markedly	ADV
bam-7218	1091	14	exacerbates	exacerbate	VERB
bam-7218	1091	15	the	the	DET
bam-7218	1091	16	pathology	pathology	NOUN
bam-7218	1091	17	.	.	PUNCT
bam-7218	1092	1	we	we	PRON
bam-7218	1092	2	therefore	therefore	ADV
bam-7218	1092	3	provide	provide	VERB
bam-7218	1092	4	evidence	evidence	NOUN
bam-7218	1092	5	that	that	SCONJ
bam-7218	1092	6	current	current	ADJ
bam-7218	1092	7	strategies	strategy	NOUN
bam-7218	1092	8	are	be	AUX
bam-7218	1092	9	based	base	VERB
bam-7218	1092	10	on	on	ADP
bam-7218	1092	11	a	a	DET
bam-7218	1092	12	misconception	misconception	NOUN
bam-7218	1092	13	and	and	CCONJ
bam-7218	1092	14	offer	offer	VERB
bam-7218	1092	15	a	a	DET
bam-7218	1092	16	proof	proof	NOUN
bam-7218	1092	17	of	of	ADP
bam-7218	1092	18	principle	principle	NOUN
bam-7218	1092	19	for	for	ADP
bam-7218	1092	20	a	a	DET
bam-7218	1092	21	novel	novel	ADJ
bam-7218	1092	22	therapeutic	therapeutic	ADJ
bam-7218	1092	23	approach	approach	NOUN
bam-7218	1092	24	.	.	PUNCT
bam-7218	1093	1	p.24	p.24	PROPN
bam-7218	1093	2	crosstalk	crosstalk	VERB
bam-7218	1093	3	between	between	ADP
bam-7218	1093	4	oxidative	oxidative	ADJ
bam-7218	1093	5	stress	stress	NOUN
bam-7218	1093	6	and	and	CCONJ
bam-7218	1093	7	inflammation	inflammation	NOUN
bam-7218	1093	8	in	in	ADP
bam-7218	1093	9	dystrophic	dystrophic	ADJ
bam-7218	1093	10	muscle	muscle	NOUN
bam-7218	1093	11	:	:	PUNCT
bam-7218	1093	12	focus	focus	VERB
bam-7218	1093	13	on	on	ADP
bam-7218	1093	14	il6	il6	NOUN
bam-7218	1093	15	signaling	signal	VERB
bam-7218	1093	16	carmen	carman	NOUN
bam-7218	1093	17	miano	miano	PROPN
bam-7218	1093	18	(	(	PUNCT
bam-7218	1093	19	a	a	X
bam-7218	1093	20	)	)	PUNCT
bam-7218	1093	21	,	,	PUNCT
bam-7218	1093	22	laura	laura	NOUN
bam-7218	1093	23	pelosi	pelosi	PROPN
bam-7218	1093	24	(	(	PUNCT
bam-7218	1093	25	a	a	PROPN
bam-7218	1093	26	)	)	PUNCT
bam-7218	1093	27	,	,	PUNCT
bam-7218	1093	28	laura	laura	PROPN
bam-7218	1093	29	forcina	forcina	VERB
bam-7218	1093	30	(	(	PUNCT
bam-7218	1093	31	a	a	X
bam-7218	1093	32	)	)	PUNCT
bam-7218	1093	33	,	,	PUNCT
bam-7218	1093	34	carmine	carmine	NOUN
bam-7218	1093	35	nicoletti	nicoletti	NOUN
bam-7218	1093	36	(	(	PUNCT
bam-7218	1093	37	a	a	X
bam-7218	1093	38	)	)	PUNCT
bam-7218	1093	39	,	,	PUNCT
bam-7218	1093	40	antonio	antonio	PROPN
bam-7218	1093	41	musarò	musarò	NOUN
bam-7218	1093	42	(	(	PUNCT
bam-7218	1093	43	a	a	DET
bam-7218	1093	44	,	,	PUNCT
bam-7218	1093	45	b	b	NOUN
bam-7218	1093	46	)	)	PUNCT
bam-7218	1093	47	(	(	PUNCT
bam-7218	1093	48	a	a	DET
bam-7218	1093	49	)	)	PUNCT
bam-7218	1093	50	institute	institute	PROPN
bam-7218	1093	51	pasteur	pasteur	PROPN
bam-7218	1093	52	cenci	cenci	PROPN
bam-7218	1093	53	-	-	PUNCT
bam-7218	1093	54	bolognetti	bolognetti	NOUN
bam-7218	1093	55	;	;	PUNCT
bam-7218	1093	56	dahfmo	dahfmo	NOUN
bam-7218	1093	57	-	-	PUNCT
bam-7218	1093	58	unit	unit	NOUN
bam-7218	1093	59	of	of	ADP
bam-7218	1093	60	histology	histology	NOUN
bam-7218	1093	61	and	and	CCONJ
bam-7218	1093	62	medical	medical	ADJ
bam-7218	1093	63	embryology	embryology	NOUN
bam-7218	1093	64	,	,	PUNCT
bam-7218	1093	65	iim	iim	PROPN
bam-7218	1093	66	,	,	PUNCT
bam-7218	1093	67	sapienza	sapienza	PROPN
bam-7218	1093	68	university	university	PROPN
bam-7218	1093	69	of	of	ADP
bam-7218	1093	70	rome	rome	PROPN
bam-7218	1093	71	;	;	PUNCT
bam-7218	1093	72	(	(	PUNCT
bam-7218	1093	73	b	b	X
bam-7218	1093	74	)	)	PUNCT
bam-7218	1093	75	center	center	NOUN
bam-7218	1093	76	for	for	ADP
bam-7218	1093	77	life	life	NOUN
bam-7218	1093	78	nano	nano	NOUN
bam-7218	1093	79	science@sapienza	science@sapienza	NOUN
bam-7218	1093	80	,	,	PUNCT
bam-7218	1093	81	istituto	istituto	X
bam-7218	1093	82	italiano	italiano	NOUN
bam-7218	1093	83	di	di	X
bam-7218	1093	84	tecnologia	tecnologia	PROPN
bam-7218	1093	85	,	,	PUNCT
bam-7218	1093	86	rome	rome	PROPN
bam-7218	1093	87	,	,	PUNCT
bam-7218	1093	88	italy	italy	PROPN
bam-7218	1093	89	.	.	PUNCT
bam-7218	1094	1	email	email	NOUN
bam-7218	1094	2	:	:	PUNCT
bam-7218	1094	3	carmen.miano@uniroma1.it	carmen.miano@uniroma1.it	NUM
bam-7218	1094	4	duchenne	duchenne	NOUN
bam-7218	1094	5	muscular	muscular	ADJ
bam-7218	1094	6	dystrophy	dystrophy	NOUN
bam-7218	1094	7	(	(	PUNCT
bam-7218	1094	8	dmd	dmd	NOUN
bam-7218	1094	9	)	)	PUNCT
bam-7218	1094	10	is	be	AUX
bam-7218	1094	11	an	an	DET
bam-7218	1094	12	x	x	ADV
bam-7218	1094	13	-	-	ADJ
bam-7218	1094	14	linked	link	VERB
bam-7218	1094	15	genetic	genetic	ADJ
bam-7218	1094	16	disorder	disorder	NOUN
bam-7218	1094	17	caused	cause	VERB
bam-7218	1094	18	by	by	ADP
bam-7218	1094	19	mutations	mutation	NOUN
bam-7218	1094	20	in	in	ADP
bam-7218	1094	21	the	the	DET
bam-7218	1094	22	dystrophin	dystrophin	ADJ
bam-7218	1094	23	gene	gene	NOUN
bam-7218	1094	24	.	.	PUNCT
bam-7218	1095	1	oxidative	oxidative	ADJ
bam-7218	1095	2	stress	stress	NOUN
bam-7218	1095	3	and	and	CCONJ
bam-7218	1095	4	chronic	chronic	ADJ
bam-7218	1095	5	inflammation	inflammation	NOUN
bam-7218	1095	6	have	have	AUX
bam-7218	1095	7	been	be	AUX
bam-7218	1095	8	proposed	propose	VERB
bam-7218	1095	9	as	as	ADP
bam-7218	1095	10	important	important	ADJ
bam-7218	1095	11	mechanisms	mechanism	NOUN
bam-7218	1095	12	involved	involve	VERB
bam-7218	1095	13	in	in	ADP
bam-7218	1095	14	dmd	dmd	NOUN
bam-7218	1095	15	.	.	PROPN
bam-7218	1095	16	under	under	ADP
bam-7218	1095	17	pathological	pathological	ADJ
bam-7218	1095	18	conditions	condition	NOUN
bam-7218	1095	19	,	,	PUNCT
bam-7218	1095	20	elevated	elevated	ADJ
bam-7218	1095	21	levels	level	NOUN
bam-7218	1095	22	of	of	ADP
bam-7218	1095	23	ros	ros	PROPN
bam-7218	1095	24	in	in	ADP
bam-7218	1095	25	skeletal	skeletal	ADJ
bam-7218	1095	26	muscle	muscle	NOUN
bam-7218	1095	27	can	can	AUX
bam-7218	1095	28	overwhelm	overwhelm	VERB
bam-7218	1095	29	cellular	cellular	ADJ
bam-7218	1095	30	antioxidant	antioxidant	ADJ
bam-7218	1095	31	defenses	defense	NOUN
bam-7218	1095	32	,	,	PUNCT
bam-7218	1095	33	leading	lead	VERB
bam-7218	1095	34	to	to	ADP
bam-7218	1095	35	oxidant	oxidant	NOUN
bam-7218	1095	36	-	-	PUNCT
bam-7218	1095	37	related	relate	VERB
bam-7218	1095	38	damage	damage	NOUN
bam-7218	1095	39	.	.	PUNCT
bam-7218	1096	1	moreover	moreover	ADV
bam-7218	1096	2	,	,	PUNCT
bam-7218	1096	3	an	an	DET
bam-7218	1096	4	alteration	alteration	NOUN
bam-7218	1096	5	in	in	ADP
bam-7218	1096	6	the	the	DET
bam-7218	1096	7	redox	redox	NOUN
bam-7218	1096	8	signaling	signal	VERB
bam-7218	1096	9	might	might	AUX
bam-7218	1096	10	stimulate	stimulate	VERB
bam-7218	1096	11	inflammatory	inflammatory	ADJ
bam-7218	1096	12	response	response	NOUN
bam-7218	1096	13	collaborating	collaborate	VERB
bam-7218	1096	14	to	to	PART
bam-7218	1096	15	produce	produce	VERB
bam-7218	1096	16	muscle	muscle	NOUN
bam-7218	1096	17	fiber	fiber	NOUN
bam-7218	1096	18	necrosis	necrosis	NOUN
bam-7218	1096	19	.	.	PUNCT
bam-7218	1097	1	to	to	ADP
bam-7218	1097	2	date	date	NOUN
bam-7218	1097	3	,	,	PUNCT
bam-7218	1097	4	inflammation	inflammation	NOUN
bam-7218	1097	5	is	be	AUX
bam-7218	1097	6	considered	consider	VERB
bam-7218	1097	7	the	the	DET
bam-7218	1097	8	principal	principal	ADJ
bam-7218	1097	9	determinant	determinant	ADJ
bam-7218	1097	10	of	of	ADP
bam-7218	1097	11	degenerative	degenerative	ADJ
bam-7218	1097	12	processes	process	NOUN
bam-7218	1097	13	in	in	ADP
bam-7218	1097	14	dystrophic	dystrophic	ADJ
bam-7218	1097	15	muscle	muscle	NOUN
bam-7218	1097	16	and	and	CCONJ
bam-7218	1097	17	treatments	treatment	NOUN
bam-7218	1097	18	are	be	AUX
bam-7218	1097	19	limited	limit	VERB
bam-7218	1097	20	to	to	ADP
bam-7218	1097	21	glucocorticoids	glucocorticoid	NOUN
bam-7218	1097	22	.	.	PUNCT
bam-7218	1098	1	however	however	ADV
bam-7218	1098	2	,	,	PUNCT
bam-7218	1098	3	a	a	DET
bam-7218	1098	4	central	central	ADJ
bam-7218	1098	5	role	role	NOUN
bam-7218	1098	6	of	of	ADP
bam-7218	1098	7	oxidative	oxidative	ADJ
bam-7218	1098	8	stress	stress	NOUN
bam-7218	1098	9	in	in	ADP
bam-7218	1098	10	dmd	dmd	PROPN
bam-7218	1098	11	pathology	pathology	NOUN
bam-7218	1098	12	has	have	AUX
bam-7218	1098	13	been	be	AUX
bam-7218	1098	14	evidenced	evidence	VERB
bam-7218	1098	15	by	by	ADP
bam-7218	1098	16	clinical	clinical	ADJ
bam-7218	1098	17	and	and	CCONJ
bam-7218	1098	18	pre	pre	ADJ
bam-7218	1098	19	-	-	ADJ
bam-7218	1098	20	clinical	clinical	ADJ
bam-7218	1098	21	studies	study	NOUN
bam-7218	1098	22	.	.	PUNCT
bam-7218	1099	1	a	a	DET
bam-7218	1099	2	potential	potential	ADJ
bam-7218	1099	3	candidate	candidate	NOUN
bam-7218	1099	4	linking	link	VERB
bam-7218	1099	5	inflammation	inflammation	NOUN
bam-7218	1099	6	and	and	CCONJ
bam-7218	1099	7	ros	ros	PROPN
bam-7218	1099	8	production	production	NOUN
bam-7218	1099	9	is	be	AUX
bam-7218	1099	10	interleukine	interleukine	ADJ
bam-7218	1099	11	6	6	NUM
bam-7218	1099	12	(	(	PUNCT
bam-7218	1099	13	il6	il6	NOUN
bam-7218	1099	14	)	)	PUNCT
bam-7218	1099	15	,	,	PUNCT
bam-7218	1099	16	a	a	DET
bam-7218	1099	17	critical	critical	ADJ
bam-7218	1099	18	factor	factor	NOUN
bam-7218	1099	19	involved	involve	VERB
bam-7218	1099	20	in	in	ADP
bam-7218	1099	21	the	the	DET
bam-7218	1099	22	switch	switch	NOUN
bam-7218	1099	23	between	between	ADP
bam-7218	1099	24	acute	acute	ADJ
bam-7218	1099	25	and	and	CCONJ
bam-7218	1099	26	chronic	chronic	ADJ
bam-7218	1099	27	inflammation	inflammation	NOUN
bam-7218	1099	28	.	.	PUNCT
bam-7218	1100	1	we	we	PRON
bam-7218	1100	2	generated	generate	VERB
bam-7218	1100	3	a	a	DET
bam-7218	1100	4	severe	severe	ADJ
bam-7218	1100	5	animal	animal	NOUN
bam-7218	1100	6	model	model	NOUN
bam-7218	1100	7	of	of	ADP
bam-7218	1100	8	dmd	dmd	NOUN
bam-7218	1100	9	,	,	PUNCT
bam-7218	1100	10	the	the	DET
bam-7218	1100	11	mdx	mdx	PROPN
bam-7218	1100	12	/	/	SYM
bam-7218	1100	13	il6	il6	PROPN
bam-7218	1100	14	mouse	mouse	NOUN
bam-7218	1100	15	,	,	PUNCT
bam-7218	1100	16	that	that	SCONJ
bam-7218	1100	17	better	well	ADJ
bam-7218	1100	18	recapitulates	recapitulate	VERB
bam-7218	1100	19	disease	disease	NOUN
bam-7218	1100	20	progression	progression	NOUN
bam-7218	1100	21	in	in	ADP
bam-7218	1100	22	human	human	ADJ
bam-7218	1100	23	pathology	pathology	NOUN
bam-7218	1100	24	and	and	CCONJ
bam-7218	1100	25	approximates	approximate	VERB
bam-7218	1100	26	the	the	DET
bam-7218	1100	27	antioxidant	antioxidant	ADJ
bam-7218	1100	28	expression	expression	NOUN
bam-7218	1100	29	profile	profile	NOUN
bam-7218	1100	30	observed	observe	VERB
bam-7218	1100	31	in	in	ADP
bam-7218	1100	32	dmd	dmd	NOUN
bam-7218	1100	33	patients	patient	NOUN
bam-7218	1100	34	.	.	PUNCT
bam-7218	1101	1	in	in	ADP
bam-7218	1101	2	particular	particular	ADJ
bam-7218	1101	3	,	,	PUNCT
bam-7218	1101	4	increased	increase	VERB
bam-7218	1101	5	circulating	circulate	VERB
bam-7218	1101	6	levels	level	NOUN
bam-7218	1101	7	of	of	ADP
bam-7218	1101	8	il6	il6	NOUN
bam-7218	1101	9	alter	alter	VERB
bam-7218	1101	10	the	the	DET
bam-7218	1101	11	redox	redox	NOUN
bam-7218	1101	12	signaling	signal	VERB
bam-7218	1101	13	cascade	cascade	NOUN
bam-7218	1101	14	in	in	ADP
bam-7218	1101	15	dystrophic	dystrophic	ADJ
bam-7218	1101	16	muscle	muscle	NOUN
bam-7218	1101	17	.	.	PUNCT
bam-7218	1102	1	p.25	p.25	PROPN
bam-7218	1102	2	caveolin-1	caveolin-1	NUM
bam-7218	1102	3	overexpression	overexpression	NOUN
bam-7218	1102	4	accelerates	accelerate	VERB
bam-7218	1102	5	tumor	tumor	NOUN
bam-7218	1102	6	growth	growth	NOUN
bam-7218	1102	7	and	and	CCONJ
bam-7218	1102	8	metastasis	metastasis	NOUN
bam-7218	1102	9	of	of	ADP
bam-7218	1102	10	embryonal	embryonal	ADJ
bam-7218	1102	11	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-7218	1102	12	luca	luca	PROPN
bam-7218	1102	13	pinardi	pinardi	PROPN
bam-7218	1102	14	(	(	PUNCT
bam-7218	1102	15	a	a	NOUN
bam-7218	1102	16	)	)	PUNCT
bam-7218	1102	17	,	,	PUNCT
bam-7218	1102	18	fiorella	fiorella	X
bam-7218	1102	19	faggi	faggi	PROPN
bam-7218	1102	20	(	(	PUNCT
bam-7218	1102	21	a	a	DET
bam-7218	1102	22	,	,	PUNCT
bam-7218	1102	23	b	b	NOUN
bam-7218	1102	24	)	)	PUNCT
bam-7218	1102	25	,	,	PUNCT
bam-7218	1102	26	roberto	roberto	PROPN
bam-7218	1102	27	ronca	ronca	PROPN
bam-7218	1102	28	(	(	PUNCT
bam-7218	1102	29	a	a	NOUN
bam-7218	1102	30	)	)	PUNCT
bam-7218	1102	31	,	,	PUNCT
bam-7218	1102	32	silvia	silvia	PROPN
bam-7218	1102	33	codenotti	codenotti	PROPN
bam-7218	1102	34	(	(	PUNCT
bam-7218	1102	35	a	a	DET
bam-7218	1102	36	,	,	PUNCT
bam-7218	1102	37	b	b	NOUN
bam-7218	1102	38	)	)	PUNCT
bam-7218	1102	39	,	,	PUNCT
bam-7218	1102	40	alessandro	alessandro	PROPN
bam-7218	1102	41	fanzani	fanzani	PROPN
bam-7218	1102	42	(	(	PUNCT
bam-7218	1102	43	a	a	DET
bam-7218	1102	44	,	,	PUNCT
bam-7218	1102	45	b	b	NOUN
bam-7218	1102	46	)	)	PUNCT
bam-7218	1102	47	*	*	PUNCT
bam-7218	1103	1	(	(	PUNCT
bam-7218	1103	2	a	a	X
bam-7218	1103	3	)	)	PUNCT
bam-7218	1103	4	dept	dept	NOUN
bam-7218	1103	5	of	of	ADP
bam-7218	1103	6	molecular	molecular	ADJ
bam-7218	1103	7	and	and	CCONJ
bam-7218	1103	8	translational	translational	ADJ
bam-7218	1103	9	medicine	medicine	NOUN
bam-7218	1103	10	,	,	PUNCT
bam-7218	1103	11	university	university	NOUN
bam-7218	1103	12	of	of	ADP
bam-7218	1103	13	brescia	brescia	PROPN
bam-7218	1103	14	,	,	PUNCT
bam-7218	1103	15	italy	italy	PROPN
bam-7218	1103	16	;	;	PUNCT
bam-7218	1103	17	(	(	PUNCT
bam-7218	1103	18	b	b	X
bam-7218	1103	19	)	)	PUNCT
bam-7218	1103	20	interuniversity	interuniversity	NOUN
bam-7218	1103	21	institute	institute	PROPN
bam-7218	1103	22	of	of	ADP
bam-7218	1103	23	myology	myology	PROPN
bam-7218	1103	24	,	,	PUNCT
bam-7218	1103	25	rome	rome	PROPN
bam-7218	1103	26	,	,	PUNCT
bam-7218	1103	27	italy	italy	PROPN
bam-7218	1103	28	.	.	PUNCT
bam-7218	1104	1	email	email	NOUN
bam-7218	1104	2	:	:	PUNCT
bam-7218	1104	3	l.pinardi94@gmail.com	l.pinardi94@gmail.com	X
bam-7218	1104	4	caveolin-1	caveolin-1	NUM
bam-7218	1104	5	(	(	PUNCT
bam-7218	1104	6	cav-1	cav-1	X
bam-7218	1104	7	)	)	PUNCT
bam-7218	1104	8	is	be	AUX
bam-7218	1104	9	a	a	DET
bam-7218	1104	10	plasma	plasma	NOUN
bam-7218	1104	11	membrane	membrane	NOUN
bam-7218	1104	12	scaffolding	scaffolding	NOUN
bam-7218	1104	13	protein	protein	NOUN
bam-7218	1104	14	that	that	PRON
bam-7218	1104	15	was	be	AUX
bam-7218	1104	16	shown	show	VERB
bam-7218	1104	17	to	to	PART
bam-7218	1104	18	control	control	VERB
bam-7218	1104	19	the	the	DET
bam-7218	1104	20	erk	erk	PROPN
bam-7218	1104	21	pathway	pathway	NOUN
bam-7218	1104	22	in	in	ADP
bam-7218	1104	23	muscle	muscle	NOUN
bam-7218	1104	24	satellite	satellite	NOUN
bam-7218	1104	25	cells	cell	NOUN
bam-7218	1104	26	.	.	PUNCT
bam-7218	1105	1	oncogenic	oncogenic	ADJ
bam-7218	1105	2	transformation	transformation	NOUN
bam-7218	1105	3	of	of	ADP
bam-7218	1105	4	satellite	satellite	NOUN
bam-7218	1105	5	cells	cell	NOUN
bam-7218	1105	6	is	be	AUX
bam-7218	1105	7	responsible	responsible	ADJ
bam-7218	1105	8	of	of	ADP
bam-7218	1105	9	the	the	DET
bam-7218	1105	10	generation	generation	NOUN
bam-7218	1105	11	of	of	ADP
bam-7218	1105	12	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-7218	1105	13	(	(	PUNCT
bam-7218	1105	14	rms	rm	NOUN
bam-7218	1105	15	)	)	PUNCT
bam-7218	1105	16	,	,	PUNCT
bam-7218	1105	17	a	a	DET
bam-7218	1105	18	soft	soft	ADJ
bam-7218	1105	19	tissue	tissue	NOUN
bam-7218	1105	20	tumor	tumor	NOUN
bam-7218	1105	21	affecting	affect	VERB
bam-7218	1105	22	childhood	childhood	NOUN
bam-7218	1105	23	and	and	CCONJ
bam-7218	1105	24	adolescence	adolescence	NOUN
bam-7218	1105	25	.	.	PUNCT
bam-7218	1106	1	we	we	PRON
bam-7218	1106	2	previously	previously	ADV
bam-7218	1106	3	reported	report	VERB
bam-7218	1106	4	that	that	SCONJ
bam-7218	1106	5	cav-1	cav-1	PUNCT
bam-7218	1106	6	is	be	AUX
bam-7218	1106	7	a	a	DET
bam-7218	1106	8	marker	marker	NOUN
bam-7218	1106	9	of	of	ADP
bam-7218	1106	10	proliferating	proliferate	VERB
bam-7218	1106	11	rms	rm	NOUN
bam-7218	1106	12	cell	cell	NOUN
bam-7218	1106	13	lines	line	NOUN
bam-7218	1106	14	and	and	CCONJ
bam-7218	1106	15	that	that	SCONJ
bam-7218	1106	16	its	its	PRON
bam-7218	1106	17	overexpression	overexpression	NOUN
bam-7218	1106	18	promotes	promote	VERB
bam-7218	1106	19	increased	increase	VERB
bam-7218	1106	20	malignancy	malignancy	NOUN
bam-7218	1106	21	of	of	ADP
bam-7218	1106	22	rms	rm	NOUN
bam-7218	1106	23	cells	cell	NOUN
bam-7218	1106	24	in	in	ADP
bam-7218	1106	25	vitro	vitro	X
bam-7218	1106	26	and	and	CCONJ
bam-7218	1106	27	in	in	ADP
bam-7218	1106	28	vivo	vivo	NOUN
bam-7218	1106	29	.	.	PUNCT
bam-7218	1107	1	here	here	ADV
bam-7218	1107	2	we	we	PRON
bam-7218	1107	3	show	show	VERB
bam-7218	1107	4	that	that	SCONJ
bam-7218	1107	5	tail	tail	NOUN
bam-7218	1107	6	vein	vein	VERB
bam-7218	1107	7	injection	injection	NOUN
bam-7218	1107	8	of	of	ADP
bam-7218	1107	9	the	the	DET
bam-7218	1107	10	human	human	ADJ
bam-7218	1107	11	embryonal	embryonal	PROPN
bam-7218	1107	12	rd	rd	NOUN
bam-7218	1107	13	cells	cell	NOUN
bam-7218	1107	14	with	with	ADP
bam-7218	1107	15	cav-1	cav-1	PUNCT
bam-7218	1107	16	overexpression	overexpression	NOUN
bam-7218	1107	17	(	(	PUNCT
bam-7218	1107	18	rd	rd	NOUN
bam-7218	1107	19	cav-1	cav-1	PUNCT
bam-7218	1107	20	)	)	PUNCT
bam-7218	1107	21	into	into	ADP
bam-7218	1107	22	nod	nod	PROPN
bam-7218	1107	23	/	/	SYM
bam-7218	1107	24	scid	scid	PROPN
bam-7218	1107	25	mice	mouse	NOUN
bam-7218	1107	26	resulted	result	VERB
bam-7218	1107	27	in	in	ADP
bam-7218	1107	28	formation	formation	NOUN
bam-7218	1107	29	of	of	ADP
bam-7218	1107	30	lung	lung	NOUN
bam-7218	1107	31	metastasis	metastasis	NOUN
bam-7218	1107	32	in	in	ADP
bam-7218	1107	33	about	about	ADV
bam-7218	1107	34	9	9	NUM
bam-7218	1107	35	weeks	week	NOUN
bam-7218	1107	36	as	as	SCONJ
bam-7218	1107	37	compared	compare	VERB
bam-7218	1107	38	to	to	ADP
bam-7218	1107	39	control	control	VERB
bam-7218	1107	40	cells	cell	NOUN
bam-7218	1107	41	that	that	PRON
bam-7218	1107	42	did	do	AUX
bam-7218	1107	43	not	not	PART
bam-7218	1107	44	form	form	VERB
bam-7218	1107	45	mailto:graziella.messina@unimi.it	mailto:graziella.messina@unimi.it	PROPN
bam-7218	1107	46	mailto:carmen.miano@uniroma1.it	mailto:carmen.miano@uniroma1.it	NOUN
bam-7218	1107	47	mailto:l.pinardi94@gmail.com	mailto:l.pinardi94@gmail.com	NOUN
bam-7218	1107	48	14	14	NUM
bam-7218	1107	49	th	th	NOUN
bam-7218	1107	50	iiim	iiim	NOUN
bam-7218	1107	51	meeting	meeting	NOUN
bam-7218	1107	52	,	,	PUNCT
bam-7218	1107	53	assisi	assisi	PROPN
bam-7218	1107	54	,	,	PUNCT
bam-7218	1107	55	italy	italy	PROPN
bam-7218	1107	56	october	october	PROPN
bam-7218	1107	57	12	12	NUM
bam-7218	1107	58	-	-	SYM
bam-7218	1107	59	15	15	NUM
bam-7218	1107	60	2017	2017	NUM
bam-7218	1107	61	eur	eur	PROPN
bam-7218	1107	62	j	j	PROPN
bam-7218	1107	63	transl	transl	PROPN
bam-7218	1107	64	myol	myol	ADV
bam-7218	1107	65	27	27	NUM
bam-7218	1107	66	(	(	PUNCT
bam-7218	1107	67	4	4	NUM
bam-7218	1107	68	):	):	SYM
bam-7218	1107	69	185	185	NUM
bam-7218	1107	70	-	-	SYM
bam-7218	1107	71	224	224	NUM
bam-7218	1107	72	219	219	NUM
bam-7218	1107	73	metastasis	metastasis	NOUN
bam-7218	1107	74	.	.	PUNCT
bam-7218	1108	1	after	after	ADP
bam-7218	1108	2	performing	perform	VERB
bam-7218	1108	3	ex	ex	PRON
bam-7218	1108	4	vivo	vivo	ADJ
bam-7218	1108	5	transplantation	transplantation	NOUN
bam-7218	1108	6	of	of	ADP
bam-7218	1108	7	lung	lung	NOUN
bam-7218	1108	8	metastases	metastasis	NOUN
bam-7218	1108	9	we	we	PRON
bam-7218	1108	10	isolated	isolate	VERB
bam-7218	1108	11	one	one	NUM
bam-7218	1108	12	cell	cell	NOUN
bam-7218	1108	13	population	population	NOUN
bam-7218	1108	14	,	,	PUNCT
bam-7218	1108	15	termed	term	VERB
bam-7218	1108	16	lung	lung	NOUN
bam-7218	1108	17	metastatic	metastatic	ADJ
bam-7218	1108	18	rd1	rd1	PROPN
bam-7218	1108	19	,	,	PUNCT
bam-7218	1108	20	which	which	PRON
bam-7218	1108	21	injected	inject	VERB
bam-7218	1108	22	in	in	ADP
bam-7218	1108	23	mice	mouse	NOUN
bam-7218	1108	24	again	again	ADV
bam-7218	1108	25	gave	give	VERB
bam-7218	1108	26	rise	rise	NOUN
bam-7218	1108	27	to	to	ADP
bam-7218	1108	28	lung	lung	NOUN
bam-7218	1108	29	metastases	metastasis	NOUN
bam-7218	1108	30	in	in	ADP
bam-7218	1108	31	5	5	NUM
bam-7218	1108	32	weeks	week	NOUN
bam-7218	1108	33	;	;	PUNCT
bam-7218	1108	34	from	from	ADP
bam-7218	1108	35	these	these	DET
bam-7218	1108	36	disseminated	disseminate	VERB
bam-7218	1108	37	lungs	lung	NOUN
bam-7218	1108	38	we	we	PRON
bam-7218	1108	39	were	be	AUX
bam-7218	1108	40	able	able	ADJ
bam-7218	1108	41	to	to	PART
bam-7218	1108	42	isolate	isolate	VERB
bam-7218	1108	43	the	the	DET
bam-7218	1108	44	lung	lung	NOUN
bam-7218	1108	45	metastatic	metastatic	NOUN
bam-7218	1108	46	rd2	rd2	PROPN
bam-7218	1108	47	cell	cell	NOUN
bam-7218	1108	48	population	population	NOUN
bam-7218	1108	49	.	.	PUNCT
bam-7218	1109	1	all	all	DET
bam-7218	1109	2	the	the	DET
bam-7218	1109	3	distinct	distinct	ADJ
bam-7218	1109	4	cell	cell	NOUN
bam-7218	1109	5	populations	population	NOUN
bam-7218	1109	6	,	,	PUNCT
bam-7218	1109	7	including	include	VERB
bam-7218	1109	8	rd	rd	PROPN
bam-7218	1109	9	cav-1	cav-1	PUNCT
bam-7218	1109	10	and	and	CCONJ
bam-7218	1109	11	lung	lung	PROPN
bam-7218	1109	12	metastatic	metastatic	PROPN
bam-7218	1109	13	rd1	rd1	PROPN
bam-7218	1109	14	and	and	CCONJ
bam-7218	1109	15	rd2	rd2	PROPN
bam-7218	1109	16	clones	clone	NOUN
bam-7218	1109	17	,	,	PUNCT
bam-7218	1109	18	retained	retain	VERB
bam-7218	1109	19	high	high	ADJ
bam-7218	1109	20	cav-1	cav-1	X
bam-7218	1109	21	expression	expression	NOUN
bam-7218	1109	22	and	and	CCONJ
bam-7218	1109	23	showed	show	VERB
bam-7218	1109	24	high	high	ADJ
bam-7218	1109	25	phosphorylation	phosphorylation	NOUN
bam-7218	1109	26	levels	level	NOUN
bam-7218	1109	27	of	of	ADP
bam-7218	1109	28	erk1/2	erk1/2	PROPN
bam-7218	1109	29	,	,	PUNCT
bam-7218	1109	30	which	which	PRON
bam-7218	1109	31	completely	completely	ADV
bam-7218	1109	32	prevented	prevent	VERB
bam-7218	1109	33	their	their	PRON
bam-7218	1109	34	ability	ability	NOUN
bam-7218	1109	35	to	to	PART
bam-7218	1109	36	undergo	undergo	VERB
bam-7218	1109	37	myogenic	myogenic	ADJ
bam-7218	1109	38	differentiation	differentiation	NOUN
bam-7218	1109	39	.	.	PUNCT
bam-7218	1110	1	in	in	ADP
bam-7218	1110	2	addition	addition	NOUN
bam-7218	1110	3	,	,	PUNCT
bam-7218	1110	4	lung	lung	NOUN
bam-7218	1110	5	metastatic	metastatic	NOUN
bam-7218	1110	6	rd1	rd1	PROPN
bam-7218	1110	7	and	and	CCONJ
bam-7218	1110	8	rd2	rd2	PROPN
bam-7218	1110	9	clones	clone	NOUN
bam-7218	1110	10	exhibited	exhibit	VERB
bam-7218	1110	11	an	an	DET
bam-7218	1110	12	increased	increase	VERB
bam-7218	1110	13	migration	migration	NOUN
bam-7218	1110	14	,	,	PUNCT
bam-7218	1110	15	adhesion	adhesion	NOUN
bam-7218	1110	16	and	and	CCONJ
bam-7218	1110	17	production	production	NOUN
bam-7218	1110	18	of	of	ADP
bam-7218	1110	19	angiogenic	angiogenic	ADJ
bam-7218	1110	20	stimuli	stimulus	NOUN
bam-7218	1110	21	in	in	ADP
bam-7218	1110	22	comparison	comparison	NOUN
bam-7218	1110	23	to	to	ADP
bam-7218	1110	24	non	non	ADJ
bam-7218	1110	25	-	-	ADJ
bam-7218	1110	26	metastatic	metastatic	ADJ
bam-7218	1110	27	control	control	PROPN
bam-7218	1110	28	rd	rd	PROPN
bam-7218	1110	29	and	and	CCONJ
bam-7218	1110	30	rd	rd	PROPN
bam-7218	1110	31	cav-1	cav-1	X
bam-7218	1110	32	lines	line	NOUN
bam-7218	1110	33	.	.	PUNCT
bam-7218	1111	1	taken	take	VERB
bam-7218	1111	2	together	together	ADV
bam-7218	1111	3	,	,	PUNCT
bam-7218	1111	4	these	these	DET
bam-7218	1111	5	data	datum	NOUN
bam-7218	1111	6	suggest	suggest	VERB
bam-7218	1111	7	a	a	DET
bam-7218	1111	8	key	key	ADJ
bam-7218	1111	9	role	role	NOUN
bam-7218	1111	10	of	of	ADP
bam-7218	1111	11	cav-1	cav-1	PUNCT
bam-7218	1111	12	in	in	ADP
bam-7218	1111	13	promoting	promote	VERB
bam-7218	1111	14	both	both	CCONJ
bam-7218	1111	15	local	local	ADJ
bam-7218	1111	16	tumor	tumor	NOUN
bam-7218	1111	17	growth	growth	NOUN
bam-7218	1111	18	and	and	CCONJ
bam-7218	1111	19	metastasis	metastasis	NOUN
bam-7218	1111	20	of	of	ADP
bam-7218	1111	21	rms	rm	NOUN
bam-7218	1111	22	through	through	ADP
bam-7218	1111	23	cooperation	cooperation	NOUN
bam-7218	1111	24	of	of	ADP
bam-7218	1111	25	the	the	DET
bam-7218	1111	26	erk	erk	NOUN
bam-7218	1111	27	signaling	signal	VERB
bam-7218	1111	28	pathway	pathway	NOUN
bam-7218	1111	29	.	.	PUNCT
bam-7218	1112	1	p.26	p.26	X
bam-7218	1112	2	oxidative	oxidative	ADJ
bam-7218	1112	3	stress	stress	NOUN
bam-7218	1112	4	in	in	ADP
bam-7218	1112	5	duchenne	duchenne	ADJ
bam-7218	1112	6	muscular	muscular	ADJ
bam-7218	1112	7	dystrophy	dystrophy	NOUN
bam-7218	1112	8	:	:	PUNCT
bam-7218	1112	9	focus	focus	VERB
bam-7218	1112	10	on	on	ADP
bam-7218	1112	11	the	the	DET
bam-7218	1112	12	nrf2	nrf2	PROPN
bam-7218	1112	13	redox	redox	NOUN
bam-7218	1112	14	pathway	pathway	NOUN
bam-7218	1112	15	sara	sara	PROPN
bam-7218	1112	16	petrillo	petrillo	PROPN
bam-7218	1112	17	(	(	PUNCT
bam-7218	1112	18	a	a	X
bam-7218	1112	19	)	)	PUNCT
bam-7218	1112	20	,	,	PUNCT
bam-7218	1112	21	laura	laura	NOUN
bam-7218	1112	22	pelosi	pelosi	PROPN
bam-7218	1112	23	(	(	PUNCT
bam-7218	1112	24	b	b	NOUN
bam-7218	1112	25	)	)	PUNCT
bam-7218	1112	26	,	,	PUNCT
bam-7218	1112	27	fiorella	fiorella	PROPN
bam-7218	1112	28	piemonte	piemonte	PROPN
bam-7218	1112	29	(	(	PUNCT
bam-7218	1112	30	a	a	X
bam-7218	1112	31	)	)	PUNCT
bam-7218	1112	32	,	,	PUNCT
bam-7218	1112	33	lorena	lorena	PROPN
bam-7218	1112	34	travaglini	travaglini	PROPN
bam-7218	1112	35	(	(	PUNCT
bam-7218	1112	36	a	a	NOUN
bam-7218	1112	37	)	)	PUNCT
bam-7218	1112	38	,	,	PUNCT
bam-7218	1112	39	laura	laura	PROPN
bam-7218	1112	40	forcina	forcina	VERB
bam-7218	1112	41	(	(	PUNCT
bam-7218	1112	42	b	b	NOUN
bam-7218	1112	43	)	)	PUNCT
bam-7218	1112	44	,	,	PUNCT
bam-7218	1112	45	michela	michela	PROPN
bam-7218	1112	46	catteruccia	catteruccia	PROPN
bam-7218	1112	47	(	(	PUNCT
bam-7218	1112	48	a	a	X
bam-7218	1112	49	)	)	PUNCT
bam-7218	1112	50	,	,	PUNCT
bam-7218	1112	51	stefania	stefania	NOUN
bam-7218	1112	52	petrini	petrini	NOUN
bam-7218	1112	53	(	(	PUNCT
bam-7218	1112	54	c	c	NOUN
bam-7218	1112	55	)	)	PUNCT
bam-7218	1112	56	,	,	PUNCT
bam-7218	1112	57	margherita	margherita	PROPN
bam-7218	1112	58	verardo	verardo	PROPN
bam-7218	1112	59	(	(	PUNCT
bam-7218	1112	60	a	a	X
bam-7218	1112	61	)	)	PUNCT
bam-7218	1112	62	,	,	PUNCT
bam-7218	1112	63	adele	adele	PROPN
bam-7218	1112	64	d’amico	d’amico	PROPN
bam-7218	1112	65	(	(	PUNCT
bam-7218	1112	66	a	a	NOUN
bam-7218	1112	67	)	)	PUNCT
bam-7218	1112	68	,	,	PUNCT
bam-7218	1112	69	antonio	antonio	PROPN
bam-7218	1112	70	musarò	musarò	NOUN
bam-7218	1112	71	(	(	PUNCT
bam-7218	1112	72	b	b	NOUN
bam-7218	1112	73	,	,	PUNCT
bam-7218	1112	74	d	d	NOUN
bam-7218	1112	75	)	)	PUNCT
bam-7218	1112	76	,	,	PUNCT
bam-7218	1112	77	enrico	enrico	PROPN
bam-7218	1112	78	bertini	bertini	PROPN
bam-7218	1112	79	(	(	PUNCT
bam-7218	1112	80	a	a	NOUN
bam-7218	1112	81	)	)	PUNCT
bam-7218	1112	82	(	(	PUNCT
bam-7218	1112	83	a	a	PRON
bam-7218	1112	84	)	)	PUNCT
bam-7218	1112	85	unit	unit	NOUN
bam-7218	1112	86	of	of	ADP
bam-7218	1112	87	muscular	muscular	ADJ
bam-7218	1112	88	and	and	CCONJ
bam-7218	1112	89	neurodegenerative	neurodegenerative	ADJ
bam-7218	1112	90	diseases	disease	NOUN
bam-7218	1112	91	,	,	PUNCT
bam-7218	1112	92	children	child	NOUN
bam-7218	1112	93	hospital	hospital	NOUN
bam-7218	1112	94	and	and	CCONJ
bam-7218	1112	95	research	research	PROPN
bam-7218	1112	96	institute	institute	PROPN
bam-7218	1112	97	bambino	bambino	PROPN
bam-7218	1112	98	gesú	gesú	PROPN
bam-7218	1112	99	;	;	PUNCT
bam-7218	1112	100	(	(	PUNCT
bam-7218	1112	101	b	b	X
bam-7218	1112	102	)	)	PUNCT
bam-7218	1112	103	dahfmo	dahfmo	NOUN
bam-7218	1112	104	-	-	PUNCT
bam-7218	1112	105	unit	unit	NOUN
bam-7218	1112	106	of	of	ADP
bam-7218	1112	107	histology	histology	NOUN
bam-7218	1112	108	and	and	CCONJ
bam-7218	1112	109	medical	medical	ADJ
bam-7218	1112	110	embryology	embryology	NOUN
bam-7218	1112	111	,	,	PUNCT
bam-7218	1112	112	laboratory	laboratory	NOUN
bam-7218	1112	113	affiliated	affiliate	VERB
bam-7218	1112	114	to	to	ADP
bam-7218	1112	115	istituto	istituto	PROPN
bam-7218	1112	116	pasteur	pasteur	PROPN
bam-7218	1112	117	italia	italia	PROPN
bam-7218	1112	118	–	–	PUNCT
bam-7218	1112	119	fondazione	fondazione	PROPN
bam-7218	1112	120	cenci	cenci	PROPN
bam-7218	1112	121	bolognetti	bolognetti	PROPN
bam-7218	1112	122	,	,	PUNCT
bam-7218	1112	123	sapienza	sapienza	PROPN
bam-7218	1112	124	university	university	PROPN
bam-7218	1112	125	;	;	PUNCT
bam-7218	1112	126	
	
	SPACE
bam-7218	1112	127	(	(	PUNCT
bam-7218	1112	128	c	c	NOUN
bam-7218	1112	129	)	)	PUNCT
bam-7218	1112	130	laboratory	laboratory	NOUN
bam-7218	1112	131	of	of	ADP
bam-7218	1112	132	research	research	NOUN
bam-7218	1112	133	,	,	PUNCT
bam-7218	1112	134	children	child	NOUN
bam-7218	1112	135	hospital	hospital	NOUN
bam-7218	1112	136	and	and	CCONJ
bam-7218	1112	137	research	research	PROPN
bam-7218	1112	138	institute	institute	PROPN
bam-7218	1112	139	bambino	bambino	PROPN
bam-7218	1112	140	gesú	gesú	PROPN
bam-7218	1112	141	;	;	PUNCT
bam-7218	1112	142	(	(	PUNCT
bam-7218	1112	143	d)center	d)center	NOUN
bam-7218	1112	144	for	for	ADP
bam-7218	1112	145	life	life	NOUN
bam-7218	1112	146	nano	nano	NOUN
bam-7218	1112	147	science@sapienza	science@sapienza	PROPN
bam-7218	1112	148	,	,	PUNCT
bam-7218	1112	149	iit	iit	PROPN
bam-7218	1112	150	,	,	PUNCT
bam-7218	1112	151	rome	rome	PROPN
bam-7218	1112	152	,	,	PUNCT
bam-7218	1112	153	italy	italy	PROPN
bam-7218	1112	154	.	.	PUNCT
bam-7218	1113	1	email	email	NOUN
bam-7218	1113	2	:	:	PUNCT
bam-7218	1113	3	sara.petrillo@opbg.net	sara.petrillo@opbg.net	NOUN
bam-7218	1113	4	oxidative	oxidative	ADJ
bam-7218	1113	5	stress	stress	NOUN
bam-7218	1113	6	is	be	AUX
bam-7218	1113	7	involved	involve	VERB
bam-7218	1113	8	in	in	ADP
bam-7218	1113	9	the	the	DET
bam-7218	1113	10	pathogenesis	pathogenesis	NOUN
bam-7218	1113	11	of	of	ADP
bam-7218	1113	12	duchenne	duchenne	ADJ
bam-7218	1113	13	muscular	muscular	ADJ
bam-7218	1113	14	dystrophy	dystrophy	NOUN
bam-7218	1113	15	(	(	PUNCT
bam-7218	1113	16	dmd	dmd	NOUN
bam-7218	1113	17	)	)	PUNCT
bam-7218	1113	18	,	,	PUNCT
bam-7218	1113	19	an	an	DET
bam-7218	1113	20	x	x	X
bam-7218	1113	21	-	-	ADJ
bam-7218	1113	22	linked	link	VERB
bam-7218	1113	23	genetic	genetic	ADJ
bam-7218	1113	24	disorder	disorder	NOUN
bam-7218	1113	25	caused	cause	VERB
bam-7218	1113	26	by	by	ADP
bam-7218	1113	27	mutations	mutation	NOUN
bam-7218	1113	28	in	in	ADP
bam-7218	1113	29	the	the	DET
bam-7218	1113	30	dystrophin	dystrophin	ADJ
bam-7218	1113	31	gene	gene	NOUN
bam-7218	1113	32	and	and	CCONJ
bam-7218	1113	33	characterized	characterize	VERB
bam-7218	1113	34	by	by	ADP
bam-7218	1113	35	progressive	progressive	ADJ
bam-7218	1113	36	,	,	PUNCT
bam-7218	1113	37	lethal	lethal	ADJ
bam-7218	1113	38	muscle	muscle	NOUN
bam-7218	1113	39	degeneration	degeneration	NOUN
bam-7218	1113	40	and	and	CCONJ
bam-7218	1113	41	chronic	chronic	ADJ
bam-7218	1113	42	inflammation	inflammation	NOUN
bam-7218	1113	43	.	.	PUNCT
bam-7218	1114	1	in	in	ADP
bam-7218	1114	2	this	this	DET
bam-7218	1114	3	study	study	NOUN
bam-7218	1114	4	,	,	PUNCT
bam-7218	1114	5	we	we	PRON
bam-7218	1114	6	explored	explore	VERB
bam-7218	1114	7	the	the	DET
bam-7218	1114	8	expression	expression	NOUN
bam-7218	1114	9	and	and	CCONJ
bam-7218	1114	10	signaling	signal	VERB
bam-7218	1114	11	pathway	pathway	NOUN
bam-7218	1114	12	of	of	ADP
bam-7218	1114	13	a	a	DET
bam-7218	1114	14	master	master	NOUN
bam-7218	1114	15	player	player	NOUN
bam-7218	1114	16	of	of	ADP
bam-7218	1114	17	the	the	DET
bam-7218	1114	18	anti	anti	ADJ
bam-7218	1114	19	-	-	ADJ
bam-7218	1114	20	oxidant	oxidant	ADJ
bam-7218	1114	21	and	and	CCONJ
bam-7218	1114	22	anti	anti	ADJ
bam-7218	1114	23	-	-	ADJ
bam-7218	1114	24	inflammatory	inflammatory	ADJ
bam-7218	1114	25	response	response	NOUN
bam-7218	1114	26	,	,	PUNCT
bam-7218	1114	27	namely	namely	ADV
bam-7218	1114	28	nf	nf	NOUN
bam-7218	1114	29	-	-	PUNCT
bam-7218	1114	30	e2	e2	NOUN
bam-7218	1114	31	-	-	PUNCT
bam-7218	1114	32	related	relate	VERB
bam-7218	1114	33	factor	factor	NOUN
bam-7218	1114	34	2	2	NUM
bam-7218	1114	35	,	,	PUNCT
bam-7218	1114	36	in	in	ADP
bam-7218	1114	37	muscle	muscle	NOUN
bam-7218	1114	38	biopsies	biopsy	NOUN
bam-7218	1114	39	of	of	ADP
bam-7218	1114	40	dmd	dmd	NOUN
bam-7218	1114	41	patients	patient	NOUN
bam-7218	1114	42	.	.	PUNCT
bam-7218	1115	1	we	we	PRON
bam-7218	1115	2	classified	classify	VERB
bam-7218	1115	3	dmd	dmd	NOUN
bam-7218	1115	4	patients	patient	NOUN
bam-7218	1115	5	in	in	ADP
bam-7218	1115	6	two	two	NUM
bam-7218	1115	7	age	age	NOUN
bam-7218	1115	8	groups	group	NOUN
bam-7218	1115	9	(	(	PUNCT
bam-7218	1115	10	class	class	NOUN
bam-7218	1115	11	i	i	PROPN
bam-7218	1115	12	,	,	PUNCT
bam-7218	1115	13	0–2	0–2	NUM
bam-7218	1115	14	years	year	NOUN
bam-7218	1115	15	and	and	CCONJ
bam-7218	1115	16	class	class	PROPN
bam-7218	1115	17	ii	ii	PROPN
bam-7218	1115	18	,	,	PUNCT
bam-7218	1115	19	2–9	2–9	NUM
bam-7218	1115	20	years	year	NOUN
bam-7218	1115	21	)	)	PUNCT
bam-7218	1115	22	,	,	PUNCT
bam-7218	1115	23	in	in	ADP
bam-7218	1115	24	order	order	NOUN
bam-7218	1115	25	to	to	PART
bam-7218	1115	26	evaluate	evaluate	VERB
bam-7218	1115	27	the	the	DET
bam-7218	1115	28	antioxidant	antioxidant	ADJ
bam-7218	1115	29	pathway	pathway	NOUN
bam-7218	1115	30	expression	expression	NOUN
bam-7218	1115	31	during	during	ADP
bam-7218	1115	32	the	the	DET
bam-7218	1115	33	disease	disease	NOUN
bam-7218	1115	34	progression	progression	NOUN
bam-7218	1115	35	.	.	PUNCT
bam-7218	1116	1	we	we	PRON
bam-7218	1116	2	observed	observe	VERB
bam-7218	1116	3	that	that	SCONJ
bam-7218	1116	4	altered	alter	VERB
bam-7218	1116	5	enzymatic	enzymatic	ADJ
bam-7218	1116	6	antioxidant	antioxidant	ADJ
bam-7218	1116	7	responses	response	NOUN
bam-7218	1116	8	,	,	PUNCT
bam-7218	1116	9	increased	increase	VERB
bam-7218	1116	10	levels	level	NOUN
bam-7218	1116	11	of	of	ADP
bam-7218	1116	12	oxidized	oxidize	VERB
bam-7218	1116	13	glutathione	glutathione	NOUN
bam-7218	1116	14	and	and	CCONJ
bam-7218	1116	15	oxidative	oxidative	ADJ
bam-7218	1116	16	damage	damage	NOUN
bam-7218	1116	17	are	be	AUX
bam-7218	1116	18	differently	differently	ADV
bam-7218	1116	19	modulated	modulate	VERB
bam-7218	1116	20	in	in	ADP
bam-7218	1116	21	the	the	DET
bam-7218	1116	22	two	two	NUM
bam-7218	1116	23	age	age	NOUN
bam-7218	1116	24	classes	class	NOUN
bam-7218	1116	25	of	of	ADP
bam-7218	1116	26	patients	patient	NOUN
bam-7218	1116	27	and	and	CCONJ
bam-7218	1116	28	well	well	ADV
bam-7218	1116	29	correlate	correlate	VERB
bam-7218	1116	30	with	with	ADP
bam-7218	1116	31	the	the	DET
bam-7218	1116	32	severity	severity	NOUN
bam-7218	1116	33	of	of	ADP
bam-7218	1116	34	pathology	pathology	NOUN
bam-7218	1116	35	.	.	PUNCT
bam-7218	1117	1	interestingly	interestingly	ADV
bam-7218	1117	2	,	,	PUNCT
bam-7218	1117	3	we	we	PRON
bam-7218	1117	4	also	also	ADV
bam-7218	1117	5	observed	observe	VERB
bam-7218	1117	6	a	a	DET
bam-7218	1117	7	modulation	modulation	NOUN
bam-7218	1117	8	of	of	ADP
bam-7218	1117	9	relevant	relevant	ADJ
bam-7218	1117	10	markers	marker	NOUN
bam-7218	1117	11	of	of	ADP
bam-7218	1117	12	the	the	DET
bam-7218	1117	13	inflammatory	inflammatory	ADJ
bam-7218	1117	14	response	response	NOUN
bam-7218	1117	15	,	,	PUNCT
bam-7218	1117	16	such	such	ADJ
bam-7218	1117	17	as	as	ADP
bam-7218	1117	18	heme	heme	NOUN
bam-7218	1117	19	oxygenase	oxygenase	NOUN
bam-7218	1117	20	1	1	NUM
bam-7218	1117	21	and	and	CCONJ
bam-7218	1117	22	inteleukin-6	inteleukin-6	NUM
bam-7218	1117	23	(	(	PUNCT
bam-7218	1117	24	il-6	il-6	NUM
bam-7218	1117	25	)	)	PUNCT
bam-7218	1117	26	,	,	PUNCT
bam-7218	1117	27	suggesting	suggest	VERB
bam-7218	1117	28	a	a	DET
bam-7218	1117	29	link	link	NOUN
bam-7218	1117	30	between	between	ADP
bam-7218	1117	31	oxidative	oxidative	ADJ
bam-7218	1117	32	stress	stress	NOUN
bam-7218	1117	33	and	and	CCONJ
bam-7218	1117	34	chronic	chronic	ADJ
bam-7218	1117	35	inflammatory	inflammatory	ADJ
bam-7218	1117	36	response	response	NOUN
bam-7218	1117	37	.	.	PUNCT
bam-7218	1118	1	of	of	ADP
bam-7218	1118	2	note	note	NOUN
bam-7218	1118	3	,	,	PUNCT
bam-7218	1118	4	using	use	VERB
bam-7218	1118	5	a	a	DET
bam-7218	1118	6	transgenic	transgenic	NOUN
bam-7218	1118	7	mouse	mouse	NOUN
bam-7218	1118	8	model	model	NOUN
bam-7218	1118	9	,	,	PUNCT
bam-7218	1118	10	we	we	PRON
bam-7218	1118	11	demonstrated	demonstrate	VERB
bam-7218	1118	12	that	that	SCONJ
bam-7218	1118	13	il-6	il-6	NOUN
bam-7218	1118	14	overexpression	overexpression	NOUN
bam-7218	1118	15	parallels	parallel	VERB
bam-7218	1118	16	the	the	DET
bam-7218	1118	17	antioxidant	antioxidant	ADJ
bam-7218	1118	18	expression	expression	NOUN
bam-7218	1118	19	profile	profile	NOUN
bam-7218	1118	20	and	and	CCONJ
bam-7218	1118	21	the	the	DET
bam-7218	1118	22	severity	severity	NOUN
bam-7218	1118	23	of	of	ADP
bam-7218	1118	24	dystrophic	dystrophic	ADJ
bam-7218	1118	25	muscle	muscle	NOUN
bam-7218	1118	26	observed	observe	VERB
bam-7218	1118	27	in	in	ADP
bam-7218	1118	28	dmd	dmd	NOUN
bam-7218	1118	29	patients	patient	NOUN
bam-7218	1118	30	.	.	PUNCT
bam-7218	1119	1	this	this	DET
bam-7218	1119	2	study	study	NOUN
bam-7218	1119	3	advances	advance	VERB
bam-7218	1119	4	our	our	PRON
bam-7218	1119	5	understanding	understanding	NOUN
bam-7218	1119	6	of	of	ADP
bam-7218	1119	7	the	the	DET
bam-7218	1119	8	pathogenic	pathogenic	ADJ
bam-7218	1119	9	mechanisms	mechanism	NOUN
bam-7218	1119	10	underlying	underlie	VERB
bam-7218	1119	11	dmd	dmd	NOUN
bam-7218	1119	12	and	and	CCONJ
bam-7218	1119	13	defines	define	VERB
bam-7218	1119	14	the	the	DET
bam-7218	1119	15	critical	critical	ADJ
bam-7218	1119	16	role	role	NOUN
bam-7218	1119	17	of	of	ADP
bam-7218	1119	18	oxidative	oxidative	ADJ
bam-7218	1119	19	stress	stress	NOUN
bam-7218	1119	20	on	on	ADP
bam-7218	1119	21	muscle	muscle	NOUN
bam-7218	1119	22	wasting	waste	VERB
bam-7218	1119	23	with	with	ADP
bam-7218	1119	24	clear	clear	ADJ
bam-7218	1119	25	implications	implication	NOUN
bam-7218	1119	26	for	for	ADP
bam-7218	1119	27	disease	disease	NOUN
bam-7218	1119	28	pathogenesis	pathogenesis	NOUN
bam-7218	1119	29	and	and	CCONJ
bam-7218	1119	30	therapy	therapy	NOUN
bam-7218	1119	31	in	in	ADP
bam-7218	1119	32	human	human	NOUN
bam-7218	1119	33	.	.	PUNCT
bam-7218	1120	1	p.27	p.27	PROPN
bam-7218	1120	2	role	role	NOUN
bam-7218	1120	3	of	of	ADP
bam-7218	1120	4	ghrelin	ghrelin	NOUN
bam-7218	1120	5	peptides	peptide	NOUN
bam-7218	1120	6	in	in	ADP
bam-7218	1120	7	aging	age	VERB
bam-7218	1120	8	simone	simone	NOUN
bam-7218	1120	9	reano	reano	NOUN
bam-7218	1120	10	(	(	PUNCT
bam-7218	1120	11	a	a	NOUN
bam-7218	1120	12	)	)	PUNCT
bam-7218	1120	13	,	,	PUNCT
bam-7218	1120	14	emanuela	emanuela	PROPN
bam-7218	1120	15	agosti	agosti	PROPN
bam-7218	1120	16	(	(	PUNCT
bam-7218	1120	17	a	a	PROPN
bam-7218	1120	18	)	)	PUNCT
bam-7218	1120	19	,	,	PUNCT
bam-7218	1120	20	elia	elia	PROPN
bam-7218	1120	21	angelino	angelino	PROPN
bam-7218	1120	22	(	(	PUNCT
bam-7218	1120	23	b	b	NOUN
bam-7218	1120	24	)	)	PUNCT
bam-7218	1120	25	,	,	PUNCT
bam-7218	1120	26	hana	hana	PROPN
bam-7218	1120	27	sustova	sustova	VERB
bam-7218	1120	28	(	(	PUNCT
bam-7218	1120	29	a	a	X
bam-7218	1120	30	)	)	PUNCT
bam-7218	1120	31	,	,	PUNCT
bam-7218	1120	32	michele	michele	PROPN
bam-7218	1120	33	ferrar	ferrar	PROPN
bam-7218	1120	34	(	(	PUNCT
bam-7218	1120	35	b	b	NOUN
bam-7218	1120	36	)	)	PUNCT
bam-7218	1120	37	,	,	PUNCT
bam-7218	1120	38	sara	sara	PROPN
bam-7218	1120	39	clerici	clerici	PROPN
bam-7218	1120	40	(	(	PUNCT
bam-7218	1120	41	b	b	NOUN
bam-7218	1120	42	)	)	PUNCT
bam-7218	1120	43	,	,	PUNCT
bam-7218	1120	44	marilisa	marilisa	VERB
bam-7218	1120	45	de	de	X
bam-7218	1120	46	feudis	feudis	X
bam-7218	1120	47	(	(	PUNCT
bam-7218	1120	48	a	a	NOUN
bam-7218	1120	49	)	)	PUNCT
bam-7218	1120	50	,	,	PUNCT
bam-7218	1120	51	andrea	andrea	PROPN
bam-7218	1120	52	graziani	graziani	PROPN
bam-7218	1120	53	(	(	PUNCT
bam-7218	1120	54	b	b	NOUN
bam-7218	1120	55	)	)	PUNCT
bam-7218	1120	56	,	,	PUNCT
bam-7218	1120	57	nicoletta	nicoletta	PROPN
bam-7218	1120	58	filigheddu	filigheddu	PROPN
bam-7218	1120	59	(	(	PUNCT
bam-7218	1120	60	a	a	NOUN
bam-7218	1120	61	)	)	PUNCT
bam-7218	1120	62	(	(	PUNCT
bam-7218	1120	63	a)university	a)university	NOUN
bam-7218	1120	64	of	of	ADP
bam-7218	1120	65	piemonte	piemonte	PROPN
bam-7218	1120	66	orientale	orientale	PROPN
bam-7218	1120	67	,	,	PUNCT
bam-7218	1120	68	dept	dept	NOUN
bam-7218	1120	69	of	of	ADP
bam-7218	1120	70	translational	translational	ADJ
bam-7218	1120	71	medicine	medicine	NOUN
bam-7218	1120	72	,	,	PUNCT
bam-7218	1120	73	novara	novara	PROPN
bam-7218	1120	74	;	;	PUNCT
bam-7218	1120	75	(	(	PUNCT
bam-7218	1120	76	b	b	X
bam-7218	1120	77	)	)	PUNCT
bam-7218	1120	78	university	university	NOUN
bam-7218	1120	79	vitasalute	vitasalute	NOUN
bam-7218	1120	80	san	san	PROPN
bam-7218	1120	81	raffaele	raffaele	PROPN
bam-7218	1120	82	,	,	PUNCT
bam-7218	1120	83	milano	milano	PROPN
bam-7218	1120	84	,	,	PUNCT
bam-7218	1120	85	italy	italy	PROPN
bam-7218	1120	86	.	.	PUNCT
bam-7218	1121	1	email	email	NOUN
bam-7218	1121	2	:	:	PUNCT
bam-7218	1121	3	simone.reano@med.unipmn.it	simone.reano@med.unipmn.it	DET
bam-7218	1121	4	sarcopenia	sarcopenia	NOUN
bam-7218	1121	5	is	be	AUX
bam-7218	1121	6	a	a	DET
bam-7218	1121	7	multifactorial	multifactorial	ADJ
bam-7218	1121	8	syndrome	syndrome	NOUN
bam-7218	1121	9	defined	define	VERB
bam-7218	1121	10	as	as	ADP
bam-7218	1121	11	the	the	DET
bam-7218	1121	12	irreversible	irreversible	ADJ
bam-7218	1121	13	loss	loss	NOUN
bam-7218	1121	14	of	of	ADP
bam-7218	1121	15	skeletal	skeletal	ADJ
bam-7218	1121	16	muscle	muscle	NOUN
bam-7218	1121	17	mass	mass	NOUN
bam-7218	1121	18	and	and	CCONJ
bam-7218	1121	19	functionality	functionality	NOUN
bam-7218	1121	20	occurring	occur	VERB
bam-7218	1121	21	during	during	ADP
bam-7218	1121	22	aging	aging	NOUN
bam-7218	1121	23	.	.	PUNCT
bam-7218	1122	1	muscle	muscle	NOUN
bam-7218	1122	2	atrophy	atrophy	NOUN
bam-7218	1122	3	and	and	CCONJ
bam-7218	1122	4	impaired	impaired	ADJ
bam-7218	1122	5	regeneration	regeneration	NOUN
bam-7218	1122	6	are	be	AUX
bam-7218	1122	7	the	the	DET
bam-7218	1122	8	main	main	ADJ
bam-7218	1122	9	features	feature	NOUN
bam-7218	1122	10	of	of	ADP
bam-7218	1122	11	this	this	DET
bam-7218	1122	12	syndrome	syndrome	NOUN
bam-7218	1122	13	but	but	CCONJ
bam-7218	1122	14	the	the	DET
bam-7218	1122	15	underlying	underlie	VERB
bam-7218	1122	16	mechanisms	mechanism	NOUN
bam-7218	1122	17	and	and	CCONJ
bam-7218	1122	18	etiology	etiology	NOUN
bam-7218	1122	19	remain	remain	VERB
bam-7218	1122	20	poorly	poorly	ADV
bam-7218	1122	21	defined	define	VERB
bam-7218	1122	22	.	.	PUNCT
bam-7218	1123	1	acylated	acylated	ADJ
bam-7218	1123	2	and	and	CCONJ
bam-7218	1123	3	unacylated	unacylated	ADJ
bam-7218	1123	4	ghrelin	ghrelin	NOUN
bam-7218	1123	5	(	(	PUNCT
bam-7218	1123	6	ag	ag	PROPN
bam-7218	1123	7	and	and	CCONJ
bam-7218	1123	8	unag	unag	ADJ
bam-7218	1123	9	,	,	PUNCT
bam-7218	1123	10	respectively	respectively	ADV
bam-7218	1123	11	)	)	PUNCT
bam-7218	1123	12	are	be	AUX
bam-7218	1123	13	circulating	circulate	VERB
bam-7218	1123	14	peptide	peptide	ADJ
bam-7218	1123	15	hormones	hormone	NOUN
bam-7218	1123	16	mainly	mainly	ADV
bam-7218	1123	17	produced	produce	VERB
bam-7218	1123	18	in	in	ADP
bam-7218	1123	19	the	the	DET
bam-7218	1123	20	stomach	stomach	NOUN
bam-7218	1123	21	.	.	PUNCT
bam-7218	1124	1	ag	ag	PROPN
bam-7218	1124	2	,	,	PUNCT
bam-7218	1124	3	through	through	ADP
bam-7218	1124	4	ghsr-1a	ghsr-1a	PROPN
bam-7218	1124	5	,	,	PUNCT
bam-7218	1124	6	induces	induce	VERB
bam-7218	1124	7	a	a	DET
bam-7218	1124	8	strong	strong	ADJ
bam-7218	1124	9	release	release	NOUN
bam-7218	1124	10	of	of	ADP
bam-7218	1124	11	gh	gh	PROPN
bam-7218	1124	12	and	and	CCONJ
bam-7218	1124	13	orexigenic	orexigenic	ADJ
bam-7218	1124	14	effects	effect	NOUN
bam-7218	1124	15	.	.	PUNCT
bam-7218	1125	1	although	although	SCONJ
bam-7218	1125	2	unag	unag	ADJ
bam-7218	1125	3	does	do	AUX
bam-7218	1125	4	not	not	PART
bam-7218	1125	5	activate	activate	VERB
bam-7218	1125	6	this	this	DET
bam-7218	1125	7	receptor	receptor	NOUN
bam-7218	1125	8	,	,	PUNCT
bam-7218	1125	9	shares	share	VERB
bam-7218	1125	10	common	common	ADJ
bam-7218	1125	11	activities	activity	NOUN
bam-7218	1125	12	with	with	ADP
bam-7218	1125	13	ag	ag	PROPN
bam-7218	1125	14	on	on	ADP
bam-7218	1125	15	skeletal	skeletal	ADJ
bam-7218	1125	16	muscle	muscle	NOUN
bam-7218	1125	17	counteracting	counteract	VERB
bam-7218	1125	18	atrophy	atrophy	NOUN
bam-7218	1125	19	and	and	CCONJ
bam-7218	1125	20	promoting	promote	VERB
bam-7218	1125	21	myoblast	myoblast	ADJ
bam-7218	1125	22	differentiation	differentiation	NOUN
bam-7218	1125	23	.	.	PUNCT
bam-7218	1126	1	moreover	moreover	ADV
bam-7218	1126	2	,	,	PUNCT
bam-7218	1126	3	unag	unag	ADJ
bam-7218	1126	4	enhances	enhance	VERB
bam-7218	1126	5	muscle	muscle	NOUN
bam-7218	1126	6	regeneration	regeneration	NOUN
bam-7218	1126	7	stimulating	stimulate	VERB
bam-7218	1126	8	satellite	satellite	NOUN
bam-7218	1126	9	cell	cell	NOUN
bam-7218	1126	10	functions	function	NOUN
bam-7218	1126	11	.	.	PUNCT
bam-7218	1127	1	ag	ag	PROPN
bam-7218	1127	2	/	/	SYM
bam-7218	1127	3	unag	unag	ADJ
bam-7218	1127	4	plasmatic	plasmatic	NOUN
bam-7218	1127	5	levels	level	NOUN
bam-7218	1127	6	change	change	VERB
bam-7218	1127	7	during	during	ADP
bam-7218	1127	8	aging	aging	NOUN
bam-7218	1127	9	and	and	CCONJ
bam-7218	1127	10	this	this	PRON
bam-7218	1127	11	may	may	AUX
bam-7218	1127	12	contribute	contribute	VERB
bam-7218	1127	13	to	to	ADP
bam-7218	1127	14	sarcopenia	sarcopenia	NOUN
bam-7218	1127	15	establishment	establishment	NOUN
bam-7218	1127	16	.	.	PUNCT
bam-7218	1128	1	we	we	PRON
bam-7218	1128	2	are	be	AUX
bam-7218	1128	3	evaluating	evaluate	VERB
bam-7218	1128	4	the	the	DET
bam-7218	1128	5	role	role	NOUN
bam-7218	1128	6	of	of	ADP
bam-7218	1128	7	ag	ag	PROPN
bam-7218	1128	8	/	/	SYM
bam-7218	1128	9	unag	unag	ADJ
bam-7218	1128	10	in	in	ADP
bam-7218	1128	11	sarcopenia	sarcopenia	PROPN
bam-7218	1128	12	prevention	prevention	NOUN
bam-7218	1128	13	by	by	ADP
bam-7218	1128	14	means	mean	NOUN
bam-7218	1128	15	of	of	ADP
bam-7218	1128	16	myh6	myh6	PROPN
bam-7218	1128	17	/	/	SYM
bam-7218	1128	18	ghrl	ghrl	NOUN
bam-7218	1128	19	transgenic	transgenic	NOUN
bam-7218	1128	20	(	(	PUNCT
bam-7218	1128	21	tg	tg	NOUN
bam-7218	1128	22	)	)	PUNCT
bam-7218	1128	23	mice	mouse	NOUN
bam-7218	1128	24	(	(	PUNCT
bam-7218	1128	25	characterized	characterize	VERB
bam-7218	1128	26	by	by	ADP
bam-7218	1128	27	high	high	ADJ
bam-7218	1128	28	levels	level	NOUN
bam-7218	1128	29	of	of	ADP
bam-7218	1128	30	circulating	circulate	VERB
bam-7218	1128	31	unag	unag	ADJ
bam-7218	1128	32	)	)	PUNCT
bam-7218	1128	33	and	and	CCONJ
bam-7218	1128	34	of	of	ADP
bam-7218	1128	35	ghrl	ghrl	NOUN
bam-7218	1128	36	-/	-/	PROPN
bam-7218	1128	37	(	(	PUNCT
bam-7218	1128	38	ko	ko	NOUN
bam-7218	1128	39	)	)	PUNCT
bam-7218	1128	40	mice	mouse	NOUN
bam-7218	1128	41	.	.	PUNCT
bam-7218	1129	1	although	although	SCONJ
bam-7218	1129	2	no	no	DET
bam-7218	1129	3	difference	difference	NOUN
bam-7218	1129	4	in	in	ADP
bam-7218	1129	5	muscle	muscle	NOUN
bam-7218	1129	6	functionality	functionality	NOUN
bam-7218	1129	7	were	be	AUX
bam-7218	1129	8	observed	observe	VERB
bam-7218	1129	9	among	among	ADP
bam-7218	1129	10	tg	tg	PROPN
bam-7218	1129	11	,	,	PUNCT
bam-7218	1129	12	ko	ko	PROPN
bam-7218	1129	13	and	and	CCONJ
bam-7218	1129	14	wt	wt	X
bam-7218	1129	15	at	at	ADP
bam-7218	1129	16	6	6	NUM
bam-7218	1129	17	and	and	CCONJ
bam-7218	1129	18	12	12	NUM
bam-7218	1129	19	months	month	NOUN
bam-7218	1129	20	,	,	PUNCT
bam-7218	1129	21	fat	fat	ADJ
bam-7218	1129	22	accumulation	accumulation	NOUN
bam-7218	1129	23	and	and	CCONJ
bam-7218	1129	24	glucose	glucose	NOUN
bam-7218	1129	25	clearance	clearance	NOUN
bam-7218	1129	26	rate	rate	NOUN
bam-7218	1129	27	were	be	AUX
bam-7218	1129	28	significantly	significantly	ADV
bam-7218	1129	29	different	different	ADJ
bam-7218	1129	30	in	in	ADP
bam-7218	1129	31	the	the	DET
bam-7218	1129	32	different	different	ADJ
bam-7218	1129	33	genotypes	genotype	NOUN
bam-7218	1129	34	.	.	PUNCT
bam-7218	1130	1	moreover	moreover	ADV
bam-7218	1130	2	,	,	PUNCT
bam-7218	1130	3	muscle	muscle	NOUN
bam-7218	1130	4	regeneration	regeneration	NOUN
bam-7218	1130	5	in	in	ADP
bam-7218	1130	6	ko	ko	PROPN
bam-7218	1130	7	mice	mouse	NOUN
bam-7218	1130	8	was	be	AUX
bam-7218	1130	9	impaired	impair	VERB
bam-7218	1130	10	,	,	PUNCT
bam-7218	1130	11	suggesting	suggest	VERB
bam-7218	1130	12	a	a	DET
bam-7218	1130	13	potential	potential	ADJ
bam-7218	1130	14	role	role	NOUN
bam-7218	1130	15	of	of	ADP
bam-7218	1130	16	ag	ag	PROPN
bam-7218	1130	17	/	/	SYM
bam-7218	1130	18	unag	unag	ADJ
bam-7218	1130	19	system	system	NOUN
bam-7218	1130	20	in	in	ADP
bam-7218	1130	21	the	the	DET
bam-7218	1130	22	sarcopenia	sarcopenia	NOUN
bam-7218	1130	23	onset	onset	VERB
bam-7218	1130	24	.	.	PUNCT
bam-7218	1131	1	supported	support	VERB
bam-7218	1131	2	by	by	ADP
bam-7218	1131	3	fondazione	fondazione	PROPN
bam-7218	1131	4	cariplo	cariplo	NOUN
bam-7218	1131	5	p.28	p.28	PRON
bam-7218	1131	6	circznf609	circznf609	PROPN
bam-7218	1131	7	:	:	PUNCT
bam-7218	1131	8	a	a	DET
bam-7218	1131	9	circular	circular	ADJ
bam-7218	1131	10	rna	rna	NOUN
bam-7218	1131	11	involved	involve	VERB
bam-7218	1131	12	in	in	ADP
bam-7218	1131	13	myoblast	myoblast	ADJ
bam-7218	1131	14	proliferation	proliferation	NOUN
bam-7218	1131	15	and	and	CCONJ
bam-7218	1131	16	in	in	ADP
bam-7218	1131	17	rhabdomyosarcoma	rhabdomyosarcoma	PROPN
bam-7218	1131	18	francesca	francesca	PROPN
bam-7218	1131	19	rossi	rossi	PROPN
bam-7218	1131	20	(	(	PUNCT
bam-7218	1131	21	a	a	NOUN
bam-7218	1131	22	)	)	PUNCT
bam-7218	1131	23	,	,	PUNCT
bam-7218	1132	1	ivano	ivano	PROPN
bam-7218	1132	2	legnini	legnini	PROPN
bam-7218	1132	3	(	(	PUNCT
bam-7218	1132	4	a	a	NOUN
bam-7218	1132	5	)	)	PUNCT
bam-7218	1132	6	,	,	PUNCT
bam-7218	1132	7	francesca	francesca	PROPN
bam-7218	1132	8	megiorni	megiorni	PROPN
bam-7218	1132	9	(	(	PUNCT
bam-7218	1132	10	b	b	NOUN
bam-7218	1132	11	)	)	PUNCT
bam-7218	1132	12	,	,	PUNCT
bam-7218	1132	13	simona	simona	PROPN
bam-7218	1132	14	camero	camero	PROPN
bam-7218	1132	15	(	(	PUNCT
bam-7218	1132	16	b	b	NOUN
bam-7218	1132	17	)	)	PUNCT
bam-7218	1132	18	,	,	PUNCT
bam-7218	1132	19	carlo	carlo	PROPN
bam-7218	1132	20	dominici	dominici	PROPN
bam-7218	1132	21	(	(	PUNCT
bam-7218	1132	22	b	b	NOUN
bam-7218	1132	23	)	)	PUNCT
bam-7218	1132	24	,	,	PUNCT
bam-7218	1132	25	olga	olga	PROPN
bam-7218	1132	26	sthandier	sthandier	PROPN
bam-7218	1132	27	(	(	PUNCT
bam-7218	1132	28	a	a	NOUN
bam-7218	1132	29	)	)	PUNCT
bam-7218	1132	30	,	,	PUNCT
bam-7218	1132	31	gaia	gaia	PROPN
bam-7218	1132	32	di	di	PROPN
bam-7218	1132	33	timoteo	timoteo	PROPN
bam-7218	1132	34	(	(	PUNCT
bam-7218	1132	35	a	a	X
bam-7218	1132	36	)	)	PUNCT
bam-7218	1132	37	,	,	PUNCT
bam-7218	1132	38	dario	dario	NOUN
bam-7218	1132	39	dattilo	dattilo	ADV
bam-7218	1132	40	(	(	PUNCT
bam-7218	1132	41	c	c	NOUN
bam-7218	1132	42	)	)	PUNCT
bam-7218	1132	43	,	,	PUNCT
bam-7218	1132	44	irene	irene	PROPN
bam-7218	1132	45	bozzoni	bozzoni	PROPN
bam-7218	1132	46	(	(	PUNCT
bam-7218	1132	47	a	a	DET
bam-7218	1132	48	,	,	PUNCT
bam-7218	1132	49	c	c	NOUN
bam-7218	1132	50	)	)	PUNCT
bam-7218	1132	51	(	(	PUNCT
bam-7218	1132	52	1	1	X
bam-7218	1132	53	)	)	PUNCT
bam-7218	1132	54	dept	dept	NOUN
bam-7218	1132	55	of	of	ADP
bam-7218	1132	56	biology	biology	NOUN
bam-7218	1132	57	and	and	CCONJ
bam-7218	1132	58	biotechnology	biotechnology	NOUN
bam-7218	1132	59	charles	charles	PROPN
bam-7218	1132	60	darwin	darwin	PROPN
bam-7218	1132	61	and	and	CCONJ
bam-7218	1132	62	ibpm	ibpm	PROPN
bam-7218	1132	63	,	,	PUNCT
bam-7218	1132	64	sapienza	sapienza	PROPN
bam-7218	1132	65	university	university	PROPN
bam-7218	1132	66	of	of	ADP
bam-7218	1132	67	rome	rome	PROPN
bam-7218	1132	68	;	;	PUNCT
bam-7218	1132	69	(	(	PUNCT
bam-7218	1132	70	b	b	X
bam-7218	1132	71	)	)	PUNCT
bam-7218	1132	72	dept	dept	NOUN
bam-7218	1132	73	of	of	ADP
bam-7218	1132	74	mailto:sara.petrillo@opbg.net	mailto:sara.petrillo@opbg.net	ADJ
bam-7218	1132	75	mailto:simone.reano@med.unipmn.it	mailto:simone.reano@med.unipmn.it	NOUN
bam-7218	1132	76	14	14	NUM
bam-7218	1132	77	th	th	NOUN
bam-7218	1132	78	iiim	iiim	NOUN
bam-7218	1132	79	meeting	meeting	NOUN
bam-7218	1132	80	,	,	PUNCT
bam-7218	1132	81	assisi	assisi	PROPN
bam-7218	1132	82	,	,	PUNCT
bam-7218	1132	83	italy	italy	PROPN
bam-7218	1132	84	october	october	PROPN
bam-7218	1132	85	12	12	NUM
bam-7218	1132	86	-	-	SYM
bam-7218	1132	87	15	15	NUM
bam-7218	1132	88	2017	2017	NUM
bam-7218	1132	89	eur	eur	PROPN
bam-7218	1132	90	j	j	PROPN
bam-7218	1132	91	transl	transl	PROPN
bam-7218	1132	92	myol	myol	ADV
bam-7218	1132	93	27	27	NUM
bam-7218	1132	94	(	(	PUNCT
bam-7218	1132	95	4	4	NUM
bam-7218	1132	96	):	):	SYM
bam-7218	1132	97	185	185	NUM
bam-7218	1132	98	-	-	SYM
bam-7218	1132	99	224	224	NUM
bam-7218	1132	100	220	220	NUM
bam-7218	1132	101	pediatrics	pediatric	NOUN
bam-7218	1132	102	and	and	CCONJ
bam-7218	1132	103	infantile	infantile	ADJ
bam-7218	1132	104	neuropsychiatry	neuropsychiatry	NOUN
bam-7218	1132	105	,	,	PUNCT
bam-7218	1132	106	sapienza	sapienza	PROPN
bam-7218	1132	107	university	university	PROPN
bam-7218	1132	108	of	of	ADP
bam-7218	1132	109	rome	rome	PROPN
bam-7218	1132	110	;	;	PUNCT
bam-7218	1132	111	(	(	PUNCT
bam-7218	1132	112	c	c	X
bam-7218	1132	113	)	)	PUNCT
bam-7218	1132	114	center	center	NOUN
bam-7218	1132	115	for	for	ADP
bam-7218	1132	116	life	life	NOUN
bam-7218	1132	117	nano	nano	NOUN
bam-7218	1132	118	science@sapienza	science@sapienza	NOUN
bam-7218	1132	119	,	,	PUNCT
bam-7218	1132	120	istituto	istituto	X
bam-7218	1132	121	italiano	italiano	NOUN
bam-7218	1132	122	di	di	X
bam-7218	1132	123	tecnologia	tecnologia	PROPN
bam-7218	1132	124	,	,	PUNCT
bam-7218	1132	125	rome	rome	PROPN
bam-7218	1132	126	,	,	PUNCT
bam-7218	1132	127	italy	italy	PROPN
bam-7218	1132	128	.	.	PUNCT
bam-7218	1132	129	email	email	NOUN
bam-7218	1132	130	:	:	PUNCT
bam-7218	1132	131	franc.rossi@uniroma1.it	franc.rossi@uniroma1.it	NOUN
bam-7218	1132	132	circular	circular	ADJ
bam-7218	1132	133	rnas	rna	NOUN
bam-7218	1132	134	represent	represent	VERB
bam-7218	1132	135	a	a	DET
bam-7218	1132	136	recently	recently	ADV
bam-7218	1132	137	re	re	VERB
bam-7218	1132	138	-	-	ADJ
bam-7218	1132	139	discovered	discover	VERB
bam-7218	1132	140	class	class	NOUN
bam-7218	1132	141	of	of	ADP
bam-7218	1132	142	covalently	covalently	ADV
bam-7218	1132	143	closed	close	VERB
bam-7218	1132	144	rnas	rna	NOUN
bam-7218	1132	145	,	,	PUNCT
bam-7218	1132	146	derived	derive	VERB
bam-7218	1132	147	from	from	ADP
bam-7218	1132	148	a	a	DET
bam-7218	1132	149	noncanonical	noncanonical	ADJ
bam-7218	1132	150	splicing	splicing	NOUN
bam-7218	1132	151	event	event	NOUN
bam-7218	1132	152	(	(	PUNCT
bam-7218	1132	153	back	back	NOUN
bam-7218	1132	154	-	-	PUNCT
bam-7218	1132	155	splicing	splicing	NOUN
bam-7218	1132	156	)	)	PUNCT
bam-7218	1132	157	,	,	PUNCT
bam-7218	1132	158	ubiquitously	ubiquitously	ADV
bam-7218	1132	159	expressed	express	VERB
bam-7218	1132	160	among	among	ADP
bam-7218	1132	161	eukaryotes	eukaryote	NOUN
bam-7218	1132	162	and	and	CCONJ
bam-7218	1132	163	conserved	conserve	VERB
bam-7218	1132	164	among	among	ADP
bam-7218	1132	165	different	different	ADJ
bam-7218	1132	166	species	specie	NOUN
bam-7218	1132	167	.	.	PUNCT
bam-7218	1133	1	we	we	PRON
bam-7218	1133	2	identified	identify	VERB
bam-7218	1133	3	several	several	ADJ
bam-7218	1133	4	circular	circular	ADJ
bam-7218	1133	5	rnas	rna	NOUN
bam-7218	1133	6	expressed	express	VERB
bam-7218	1133	7	during	during	ADP
bam-7218	1133	8	myogenesis	myogenesis	NOUN
bam-7218	1133	9	.	.	PUNCT
bam-7218	1134	1	thanks	thank	NOUN
bam-7218	1134	2	to	to	ADP
bam-7218	1134	3	a	a	DET
bam-7218	1134	4	knockdownbased	knockdownbase	VERB
bam-7218	1134	5	phenotypic	phenotypic	ADJ
bam-7218	1134	6	screening	screening	NOUN
bam-7218	1134	7	,	,	PUNCT
bam-7218	1134	8	we	we	PRON
bam-7218	1134	9	identified	identify	VERB
bam-7218	1134	10	a	a	DET
bam-7218	1134	11	circrna	circrna	NOUN
bam-7218	1134	12	,	,	PUNCT
bam-7218	1134	13	named	name	VERB
bam-7218	1134	14	circznf609	circznf609	PROPN
bam-7218	1134	15	,	,	PUNCT
bam-7218	1134	16	involved	involve	VERB
bam-7218	1134	17	in	in	ADP
bam-7218	1134	18	the	the	DET
bam-7218	1134	19	regulation	regulation	NOUN
bam-7218	1134	20	of	of	ADP
bam-7218	1134	21	human	human	ADJ
bam-7218	1134	22	myoblast	myoblast	ADJ
bam-7218	1134	23	proliferation	proliferation	NOUN
bam-7218	1134	24	.	.	PUNCT
bam-7218	1135	1	upon	upon	SCONJ
bam-7218	1135	2	its	its	PRON
bam-7218	1135	3	depletion	depletion	NOUN
bam-7218	1135	4	,	,	PUNCT
bam-7218	1135	5	the	the	DET
bam-7218	1135	6	percentage	percentage	NOUN
bam-7218	1135	7	of	of	ADP
bam-7218	1135	8	proliferating	proliferate	VERB
bam-7218	1135	9	cells	cell	NOUN
bam-7218	1135	10	is	be	AUX
bam-7218	1135	11	highly	highly	ADV
bam-7218	1135	12	reduced	reduce	VERB
bam-7218	1135	13	with	with	ADP
bam-7218	1135	14	respect	respect	NOUN
bam-7218	1135	15	to	to	ADP
bam-7218	1135	16	the	the	DET
bam-7218	1135	17	control	control	NOUN
bam-7218	1135	18	sample	sample	NOUN
bam-7218	1135	19	.	.	PUNCT
bam-7218	1136	1	circznf609	circznf609	PROPN
bam-7218	1136	2	also	also	ADV
bam-7218	1136	3	has	have	VERB
bam-7218	1136	4	an	an	DET
bam-7218	1136	5	open	open	ADJ
bam-7218	1136	6	reading	reading	NOUN
bam-7218	1136	7	frame	frame	NOUN
bam-7218	1136	8	generated	generate	VERB
bam-7218	1136	9	upon	upon	SCONJ
bam-7218	1136	10	circularization	circularization	NOUN
bam-7218	1136	11	and	and	CCONJ
bam-7218	1136	12	it	it	PRON
bam-7218	1136	13	can	can	AUX
bam-7218	1136	14	encode	encode	VERB
bam-7218	1136	15	a	a	DET
bam-7218	1136	16	peptide	peptide	NOUN
bam-7218	1136	17	.	.	PUNCT
bam-7218	1137	1	here	here	ADV
bam-7218	1137	2	we	we	PRON
bam-7218	1137	3	focus	focus	VERB
bam-7218	1137	4	on	on	ADP
bam-7218	1137	5	circznf609	circznf609	PROPN
bam-7218	1137	6	role	role	NOUN
bam-7218	1137	7	in	in	ADP
bam-7218	1137	8	regulating	regulate	VERB
bam-7218	1137	9	cell	cell	NOUN
bam-7218	1137	10	cycle	cycle	NOUN
bam-7218	1137	11	progression	progression	NOUN
bam-7218	1137	12	.	.	PUNCT
bam-7218	1138	1	an	an	DET
bam-7218	1138	2	rnaseq	rnaseq	NOUN
bam-7218	1138	3	experiment	experiment	NOUN
bam-7218	1138	4	performed	perform	VERB
bam-7218	1138	5	on	on	ADP
bam-7218	1138	6	human	human	ADJ
bam-7218	1138	7	myoblasts	myoblast	NOUN
bam-7218	1138	8	revealed	reveal	VERB
bam-7218	1138	9	that	that	SCONJ
bam-7218	1138	10	the	the	DET
bam-7218	1138	11	expression	expression	NOUN
bam-7218	1138	12	of	of	ADP
bam-7218	1138	13	300	300	NUM
bam-7218	1138	14	genes	gene	NOUN
bam-7218	1138	15	is	be	AUX
bam-7218	1138	16	altered	alter	VERB
bam-7218	1138	17	upon	upon	SCONJ
bam-7218	1138	18	circznf609	circznf609	PROPN
bam-7218	1138	19	specific	specific	ADJ
bam-7218	1138	20	depletion	depletion	NOUN
bam-7218	1138	21	,	,	PUNCT
bam-7218	1138	22	of	of	ADP
bam-7218	1138	23	which	which	PRON
bam-7218	1138	24	60	60	NUM
bam-7218	1138	25	%	%	NOUN
bam-7218	1138	26	are	be	AUX
bam-7218	1138	27	downregulated	downregulate	VERB
bam-7218	1138	28	,	,	PUNCT
bam-7218	1138	29	and	and	CCONJ
bam-7218	1138	30	specifically	specifically	ADV
bam-7218	1138	31	enriched	enrich	VERB
bam-7218	1138	32	for	for	ADP
bam-7218	1138	33	cell	cell	NOUN
bam-7218	1138	34	cycle	cycle	NOUN
bam-7218	1138	35	related	relate	VERB
bam-7218	1138	36	genes	gene	NOUN
bam-7218	1138	37	.	.	PUNCT
bam-7218	1139	1	to	to	PART
bam-7218	1139	2	deepen	deepen	VERB
bam-7218	1139	3	our	our	PRON
bam-7218	1139	4	knowledge	knowledge	NOUN
bam-7218	1139	5	about	about	ADP
bam-7218	1139	6	circznf609	circznf609	PROPN
bam-7218	1139	7	role	role	NOUN
bam-7218	1139	8	in	in	ADP
bam-7218	1139	9	proliferation	proliferation	NOUN
bam-7218	1139	10	,	,	PUNCT
bam-7218	1139	11	we	we	PRON
bam-7218	1139	12	studied	study	VERB
bam-7218	1139	13	its	its	PRON
bam-7218	1139	14	expression	expression	NOUN
bam-7218	1139	15	and	and	CCONJ
bam-7218	1139	16	function	function	NOUN
bam-7218	1139	17	in	in	ADP
bam-7218	1139	18	rhabdomyosarcoma	rhabdomyosarcoma	NOUN
bam-7218	1139	19	(	(	PUNCT
bam-7218	1139	20	rms	rm	NOUN
bam-7218	1139	21	)	)	PUNCT
bam-7218	1139	22	,	,	PUNCT
bam-7218	1139	23	a	a	DET
bam-7218	1139	24	pediatric	pediatric	ADJ
bam-7218	1139	25	muscle	muscle	NOUN
bam-7218	1139	26	malignancy	malignancy	NOUN
bam-7218	1139	27	.	.	PUNCT
bam-7218	1140	1	we	we	PRON
bam-7218	1140	2	found	find	VERB
bam-7218	1140	3	that	that	SCONJ
bam-7218	1140	4	circznf609	circznf609	PROPN
bam-7218	1140	5	is	be	AUX
bam-7218	1140	6	strongly	strongly	ADV
bam-7218	1140	7	upregulated	upregulate	VERB
bam-7218	1140	8	in	in	ADP
bam-7218	1140	9	biopsies	biopsy	NOUN
bam-7218	1140	10	from	from	ADP
bam-7218	1140	11	the	the	DET
bam-7218	1140	12	two	two	NUM
bam-7218	1140	13	major	major	ADJ
bam-7218	1140	14	rms	rm	NOUN
bam-7218	1140	15	subtypes	subtype	NOUN
bam-7218	1140	16	,	,	PUNCT
bam-7218	1140	17	the	the	DET
bam-7218	1140	18	embryonal	embryonal	ADJ
bam-7218	1140	19	and	and	CCONJ
bam-7218	1140	20	the	the	DET
bam-7218	1140	21	alveolar	alveolar	NOUN
bam-7218	1140	22	,	,	PUNCT
bam-7218	1140	23	and	and	CCONJ
bam-7218	1140	24	we	we	PRON
bam-7218	1140	25	discovered	discover	VERB
bam-7218	1140	26	that	that	SCONJ
bam-7218	1140	27	its	its	PRON
bam-7218	1140	28	knockdown	knockdown	NOUN
bam-7218	1140	29	blocks	block	VERB
bam-7218	1140	30	proliferation	proliferation	NOUN
bam-7218	1140	31	of	of	ADP
bam-7218	1140	32	an	an	DET
bam-7218	1140	33	rms	rm	NOUN
bam-7218	1140	34	-	-	PUNCT
bam-7218	1140	35	derived	derive	VERB
bam-7218	1140	36	cell	cell	NOUN
bam-7218	1140	37	line	line	NOUN
bam-7218	1140	38	,	,	PUNCT
bam-7218	1140	39	promoting	promote	VERB
bam-7218	1140	40	an	an	DET
bam-7218	1140	41	accumulation	accumulation	NOUN
bam-7218	1140	42	of	of	ADP
bam-7218	1140	43	cells	cell	NOUN
bam-7218	1140	44	in	in	ADP
bam-7218	1140	45	g1	g1	PROPN
bam-7218	1140	46	cell	cell	NOUN
bam-7218	1140	47	cycle	cycle	NOUN
bam-7218	1140	48	phase	phase	NOUN
bam-7218	1140	49	,	,	PUNCT
bam-7218	1140	50	with	with	ADP
bam-7218	1140	51	a	a	DET
bam-7218	1140	52	reduction	reduction	NOUN
bam-7218	1140	53	of	of	ADP
bam-7218	1140	54	cells	cell	NOUN
bam-7218	1140	55	in	in	ADP
bam-7218	1140	56	s	s	NOUN
bam-7218	1140	57	phase	phase	NOUN
bam-7218	1140	58	.	.	PUNCT
bam-7218	1141	1	these	these	DET
bam-7218	1141	2	results	result	NOUN
bam-7218	1141	3	suggest	suggest	VERB
bam-7218	1141	4	that	that	SCONJ
bam-7218	1141	5	circznf609	circznf609	NOUN
bam-7218	1141	6	could	could	AUX
bam-7218	1141	7	be	be	AUX
bam-7218	1141	8	a	a	DET
bam-7218	1141	9	good	good	ADJ
bam-7218	1141	10	target	target	NOUN
bam-7218	1141	11	for	for	ADP
bam-7218	1141	12	therapeutic	therapeutic	ADJ
bam-7218	1141	13	approaches	approach	NOUN
bam-7218	1141	14	against	against	ADP
bam-7218	1141	15	rms	rm	NOUN
bam-7218	1141	16	.	.	PUNCT
bam-7218	1142	1	we	we	PRON
bam-7218	1142	2	are	be	AUX
bam-7218	1142	3	now	now	ADV
bam-7218	1142	4	testing	test	VERB
bam-7218	1142	5	the	the	DET
bam-7218	1142	6	effect	effect	NOUN
bam-7218	1142	7	of	of	ADP
bam-7218	1142	8	its	its	PRON
bam-7218	1142	9	depletion	depletion	NOUN
bam-7218	1142	10	on	on	ADP
bam-7218	1142	11	tumor	tumor	NOUN
bam-7218	1142	12	growth	growth	NOUN
bam-7218	1142	13	in	in	ADP
bam-7218	1142	14	xenograft	xenograft	NOUN
bam-7218	1142	15	mice	mouse	NOUN
bam-7218	1142	16	,	,	PUNCT
bam-7218	1142	17	injected	inject	VERB
bam-7218	1142	18	with	with	ADP
bam-7218	1142	19	a	a	DET
bam-7218	1142	20	stable	stable	ADJ
bam-7218	1142	21	rms	rm	NOUN
bam-7218	1142	22	cell	cell	NOUN
bam-7218	1142	23	line	line	NOUN
bam-7218	1142	24	expressing	express	VERB
bam-7218	1142	25	an	an	DET
bam-7218	1142	26	sirna	sirna	NOUN
bam-7218	1142	27	against	against	ADP
bam-7218	1142	28	circznf609	circznf609	PROPN
bam-7218	1142	29	upon	upon	SCONJ
bam-7218	1142	30	doxycycline	doxycycline	NOUN
bam-7218	1142	31	induction	induction	NOUN
bam-7218	1142	32	.	.	PUNCT
bam-7218	1143	1	p.29	p.29	NOUN
bam-7218	1143	2	sertoli	sertoli	NOUN
bam-7218	1143	3	cells	cell	NOUN
bam-7218	1143	4	protect	protect	VERB
bam-7218	1143	5	c2c12	c2c12	PROPN
bam-7218	1143	6	myotubes	myotube	NOUN
bam-7218	1143	7	against	against	ADP
bam-7218	1143	8	atrophy	atrophy	NOUN
bam-7218	1143	9	and	and	CCONJ
bam-7218	1143	10	induce	induce	VERB
bam-7218	1143	11	utrophin	utrophin	ADJ
bam-7218	1143	12	expression	expression	NOUN
bam-7218	1143	13	in	in	ADP
bam-7218	1143	14	canine	canine	NOUN
bam-7218	1143	15	and	and	CCONJ
bam-7218	1143	16	human	human	ADJ
bam-7218	1143	17	dystrophic	dystrophic	ADJ
bam-7218	1143	18	myotubes	myotube	NOUN
bam-7218	1143	19	laura	laura	PROPN
bam-7218	1143	20	salvadori	salvadori	PROPN
bam-7218	1143	21	(	(	PUNCT
bam-7218	1143	22	a	a	PROPN
bam-7218	1143	23	)	)	PUNCT
bam-7218	1143	24	*	*	PUNCT
bam-7218	1143	25	,	,	PUNCT
bam-7218	1143	26	sara	sara	PROPN
bam-7218	1143	27	chiappalupi	chiappalupi	PROPN
bam-7218	1143	28	(	(	PUNCT
bam-7218	1143	29	a	a	NOUN
bam-7218	1143	30	)	)	PUNCT
bam-7218	1143	31	*	*	PUNCT
bam-7218	1143	32	,	,	PUNCT
bam-7218	1143	33	giovanni	giovanni	PROPN
bam-7218	1143	34	luca	luca	PROPN
bam-7218	1143	35	(	(	PUNCT
bam-7218	1143	36	a	a	NOUN
bam-7218	1143	37	)	)	PUNCT
bam-7218	1143	38	*	*	PUNCT
bam-7218	1143	39	,	,	PUNCT
bam-7218	1143	40	roberta	roberta	PROPN
bam-7218	1143	41	sagheddu	sagheddu	PROPN
bam-7218	1143	42	(	(	PUNCT
bam-7218	1143	43	a	a	X
bam-7218	1143	44	)	)	PUNCT
bam-7218	1143	45	,	,	PUNCT
bam-7218	1143	46	francesca	francesca	PROPN
bam-7218	1143	47	riuzzi	riuzzi	NOUN
bam-7218	1143	48	(	(	PUNCT
bam-7218	1143	49	a	a	X
bam-7218	1143	50	)	)	PUNCT
bam-7218	1143	51	,	,	PUNCT
bam-7218	1143	52	francesca	francesca	PROPN
bam-7218	1143	53	mancuso	mancuso	PROPN
bam-7218	1143	54	(	(	PUNCT
bam-7218	1143	55	a	a	PROPN
bam-7218	1143	56	)	)	PUNCT
bam-7218	1143	57	,	,	PUNCT
bam-7218	1143	58	mario	mario	PROPN
bam-7218	1143	59	calvitti	calvitti	PROPN
bam-7218	1143	60	(	(	PUNCT
bam-7218	1143	61	a	a	NOUN
bam-7218	1143	62	)	)	PUNCT
bam-7218	1143	63	,	,	PUNCT
bam-7218	1143	64	iva	iva	PROPN
bam-7218	1143	65	arato	arato	NOUN
bam-7218	1143	66	(	(	PUNCT
bam-7218	1143	67	a	a	X
bam-7218	1143	68	)	)	PUNCT
bam-7218	1143	69	,	,	PUNCT
bam-7218	1143	70	ester	ester	NOUN
bam-7218	1143	71	sara	sara	PROPN
bam-7218	1143	72	di	di	PROPN
bam-7218	1143	73	filippo	filippo	PROPN
bam-7218	1143	74	(	(	PUNCT
bam-7218	1143	75	c	c	NOUN
bam-7218	1143	76	)	)	PUNCT
bam-7218	1143	77	,	,	PUNCT
bam-7218	1143	78	stefania	stefania	NOUN
bam-7218	1143	79	full	full	ADJ
bam-7218	1143	80	(	(	PUNCT
bam-7218	1143	81	c	c	NOUN
bam-7218	1143	82	)	)	PUNCT
bam-7218	1143	83	,	,	PUNCT
bam-7218	1143	84	riccardo	riccardo	PROPN
bam-7218	1143	85	calafiore	calafiore	PROPN
bam-7218	1143	86	(	(	PUNCT
bam-7218	1143	87	b	b	NOUN
bam-7218	1143	88	)	)	PUNCT
bam-7218	1143	89	,	,	PUNCT
bam-7218	1143	90	rosario	rosario	PROPN
bam-7218	1143	91	donato	donato	PROPN
bam-7218	1143	92	(	(	PUNCT
bam-7218	1143	93	a	a	NOUN
bam-7218	1143	94	)	)	PUNCT
bam-7218	1143	95	,	,	PUNCT
bam-7218	1143	96	guglielmo	guglielmo	PROPN
bam-7218	1143	97	sorci	sorci	VERB
bam-7218	1143	98	(	(	PUNCT
bam-7218	1143	99	a	a	NOUN
bam-7218	1143	100	)	)	PUNCT
bam-7218	1143	101	(	(	PUNCT
bam-7218	1143	102	a	a	X
bam-7218	1143	103	)	)	PUNCT
bam-7218	1143	104	dept	dept	ADJ
bam-7218	1143	105	experimental	experimental	ADJ
bam-7218	1143	106	medicine	medicine	NOUN
bam-7218	1143	107	,	,	PUNCT
bam-7218	1143	108	university	university	PROPN
bam-7218	1143	109	of	of	ADP
bam-7218	1143	110	perugia	perugia	PROPN
bam-7218	1143	111	;	;	PUNCT
bam-7218	1143	112	(	(	PUNCT
bam-7218	1143	113	b	b	X
bam-7218	1143	114	)	)	PUNCT
bam-7218	1143	115	dept	dept	ADJ
bam-7218	1143	116	internal	internal	ADJ
bam-7218	1143	117	medicine	medicine	NOUN
bam-7218	1143	118	,	,	PUNCT
bam-7218	1143	119	university	university	PROPN
bam-7218	1143	120	of	of	ADP
bam-7218	1143	121	perugia	perugia	PROPN
bam-7218	1143	122	;	;	PUNCT
bam-7218	1143	123	(	(	PUNCT
bam-7218	1143	124	c	c	X
bam-7218	1143	125	)	)	PUNCT
bam-7218	1143	126	dept	dept	NOUN
bam-7218	1143	127	neuroscience	neuroscience	NOUN
bam-7218	1143	128	imaging	imaging	NOUN
bam-7218	1143	129	and	and	CCONJ
bam-7218	1143	130	clinical	clinical	ADJ
bam-7218	1143	131	sciences	science	NOUN
bam-7218	1143	132	,	,	PUNCT
bam-7218	1143	133	university	university	NOUN
bam-7218	1143	134	"	"	PUNCT
bam-7218	1143	135	g.	g.	PROPN
bam-7218	1143	136	d'annunzio	d'annunzio	PROPN
bam-7218	1143	137	"	"	PUNCT
bam-7218	1143	138	chieti	chieti	PROPN
bam-7218	1143	139	-	-	PUNCT
bam-7218	1143	140	pescara	pescara	PROPN
bam-7218	1143	141	,	,	PUNCT
bam-7218	1143	142	chieti	chieti	PROPN
bam-7218	1143	143	,	,	PUNCT
bam-7218	1143	144	italy	italy	PROPN
bam-7218	1143	145	.	.	PUNCT
bam-7218	1144	1	email	email	PROPN
bam-7218	1144	2	:	:	PUNCT
bam-7218	1144	3	laurasalvadori1988@gmail.com	laurasalvadori1988@gmail.com	PROPN
bam-7218	1144	4	sertoli	sertoli	PROPN
bam-7218	1144	5	cells	cell	NOUN
bam-7218	1144	6	(	(	PUNCT
bam-7218	1144	7	sec	sec	PROPN
bam-7218	1144	8	)	)	PUNCT
bam-7218	1144	9	,	,	PUNCT
bam-7218	1144	10	which	which	PRON
bam-7218	1144	11	are	be	AUX
bam-7218	1144	12	crucial	crucial	ADJ
bam-7218	1144	13	for	for	ADP
bam-7218	1144	14	germinal	germinal	ADJ
bam-7218	1144	15	cell	cell	NOUN
bam-7218	1144	16	development	development	NOUN
bam-7218	1144	17	,	,	PUNCT
bam-7218	1144	18	have	have	AUX
bam-7218	1144	19	demonstrated	demonstrate	VERB
bam-7218	1144	20	trophic	trophic	ADJ
bam-7218	1144	21	and	and	CCONJ
bam-7218	1144	22	immunomodulatory	immunomodulatory	ADJ
bam-7218	1144	23	effects	effect	NOUN
bam-7218	1144	24	in	in	ADP
bam-7218	1144	25	numerous	numerous	ADJ
bam-7218	1144	26	experimental	experimental	ADJ
bam-7218	1144	27	setting	setting	NOUN
bam-7218	1144	28	.	.	PUNCT
bam-7218	1145	1	1	1	NUM
bam-7218	1145	2	a	a	DET
bam-7218	1145	3	single	single	ADJ
bam-7218	1145	4	injection	injection	NOUN
bam-7218	1145	5	of	of	ADP
bam-7218	1145	6	microencapsulated	microencapsulate	VERB
bam-7218	1145	7	sec	sec	PROPN
bam-7218	1145	8	into	into	ADP
bam-7218	1145	9	the	the	DET
bam-7218	1145	10	peritoneal	peritoneal	ADJ
bam-7218	1145	11	cavity	cavity	NOUN
bam-7218	1145	12	of	of	ADP
bam-7218	1145	13	mdx	mdx	NOUN
bam-7218	1145	14	mice	mouse	NOUN
bam-7218	1145	15	,	,	PUNCT
bam-7218	1145	16	an	an	DET
bam-7218	1145	17	experimental	experimental	ADJ
bam-7218	1145	18	model	model	NOUN
bam-7218	1145	19	of	of	ADP
bam-7218	1145	20	duchenne	duchenne	PROPN
bam-7218	1145	21	muscular	muscular	ADJ
bam-7218	1145	22	dystrophy	dystrophy	NOUN
bam-7218	1145	23	(	(	PUNCT
bam-7218	1145	24	dmd	dmd	NOUN
bam-7218	1145	25	)	)	PUNCT
bam-7218	1145	26	,	,	PUNCT
bam-7218	1145	27	results	result	VERB
bam-7218	1145	28	into	into	ADP
bam-7218	1145	29	recovery	recovery	NOUN
bam-7218	1145	30	of	of	ADP
bam-7218	1145	31	muscle	muscle	NOUN
bam-7218	1145	32	architecture	architecture	NOUN
bam-7218	1145	33	and	and	CCONJ
bam-7218	1145	34	performance	performance	NOUN
bam-7218	1145	35	in	in	ADP
bam-7218	1145	36	the	the	DET
bam-7218	1145	37	absence	absence	NOUN
bam-7218	1145	38	of	of	ADP
bam-7218	1145	39	any	any	DET
bam-7218	1145	40	pharmacological	pharmacological	ADJ
bam-7218	1145	41	immunosuppression	immunosuppression	NOUN
bam-7218	1145	42	,	,	PUNCT
bam-7218	1145	43	opening	opening	NOUN
bam-7218	1145	44	to	to	ADP
bam-7218	1145	45	new	new	ADJ
bam-7218	1145	46	perspectives	perspective	NOUN
bam-7218	1145	47	for	for	ADP
bam-7218	1145	48	dmd	dmd	NOUN
bam-7218	1145	49	treatment	treatment	NOUN
bam-7218	1145	50	.	.	PUNCT
bam-7218	1146	1	2	2	NUM
bam-7218	1146	2	besides	besides	SCONJ
bam-7218	1146	3	restraining	restrain	VERB
bam-7218	1146	4	muscle	muscle	NOUN
bam-7218	1146	5	inflammation	inflammation	NOUN
bam-7218	1146	6	,	,	PUNCT
bam-7218	1146	7	treatment	treatment	NOUN
bam-7218	1146	8	of	of	ADP
bam-7218	1146	9	mdx	mdx	NOUN
bam-7218	1146	10	mice	mouse	NOUN
bam-7218	1146	11	with	with	ADP
bam-7218	1146	12	microencapsulated	microencapsulate	VERB
bam-7218	1146	13	sec	sec	PROPN
bam-7218	1146	14	induced	induce	VERB
bam-7218	1146	15	at	at	ADP
bam-7218	1146	16	the	the	DET
bam-7218	1146	17	sarcolemma	sarcolemma	NOUN
bam-7218	1146	18	of	of	ADP
bam-7218	1146	19	myofibers	myofiber	NOUN
bam-7218	1146	20	the	the	DET
bam-7218	1146	21	expression	expression	NOUN
bam-7218	1146	22	of	of	ADP
bam-7218	1146	23	the	the	DET
bam-7218	1146	24	dystrophin	dystrophin	ADJ
bam-7218	1146	25	paralogue	paralogue	NOUN
bam-7218	1146	26	,	,	PUNCT
bam-7218	1146	27	utrophin	utrophin	ADJ
bam-7218	1146	28	,	,	PUNCT
bam-7218	1146	29	thus	thus	ADV
bam-7218	1146	30	conferring	confer	VERB
bam-7218	1146	31	an	an	DET
bam-7218	1146	32	additional	additional	ADJ
bam-7218	1146	33	advantage	advantage	NOUN
bam-7218	1146	34	to	to	ADP
bam-7218	1146	35	dystrophic	dystrophic	ADJ
bam-7218	1146	36	muscles	muscle	NOUN
bam-7218	1146	37	.	.	PUNCT
bam-7218	1147	1	2	2	NUM
bam-7218	1147	2	however	however	ADV
bam-7218	1147	3	,	,	PUNCT
bam-7218	1147	4	the	the	DET
bam-7218	1147	5	direct	direct	ADJ
bam-7218	1147	6	effects	effect	NOUN
bam-7218	1147	7	of	of	ADP
bam-7218	1147	8	sec	sec	PROPN
bam-7218	1147	9	on	on	ADP
bam-7218	1147	10	myoblasts	myoblast	NOUN
bam-7218	1147	11	/	/	SYM
bam-7218	1147	12	myotubes	myotube	NOUN
bam-7218	1147	13	themselves	themselves	PRON
bam-7218	1147	14	and	and	CCONJ
bam-7218	1147	15	on	on	ADP
bam-7218	1147	16	myotubes	myotube	NOUN
bam-7218	1147	17	of	of	ADP
bam-7218	1147	18	higher	high	ADJ
bam-7218	1147	19	mammals	mammal	NOUN
bam-7218	1147	20	have	have	AUX
bam-7218	1147	21	not	not	PART
bam-7218	1147	22	been	be	AUX
bam-7218	1147	23	investigated	investigate	VERB
bam-7218	1147	24	yet	yet	ADV
bam-7218	1147	25	.	.	PUNCT
bam-7218	1148	1	c2c12	c2c12	PROPN
bam-7218	1148	2	myotubes	myotube	NOUN
bam-7218	1148	3	treated	treat	VERB
bam-7218	1148	4	with	with	ADP
bam-7218	1148	5	tnfα	tnfα	NOUN
bam-7218	1148	6	/	/	SYM
bam-7218	1148	7	ifnγ	ifnγ	NOUN
bam-7218	1148	8	or	or	CCONJ
bam-7218	1148	9	cultured	cultured	ADJ
bam-7218	1148	10	in	in	ADP
bam-7218	1148	11	pbs	pbs	PROPN
bam-7218	1148	12	(	(	PUNCT
bam-7218	1148	13	phosphate	phosphate	ADJ
bam-7218	1148	14	buffered	buffer	VERB
bam-7218	1148	15	saline	saline	NOUN
bam-7218	1148	16	)	)	PUNCT
bam-7218	1148	17	to	to	PART
bam-7218	1148	18	mimic	mimic	VERB
bam-7218	1148	19	atrophying	atrophy	VERB
bam-7218	1148	20	conditions	condition	NOUN
bam-7218	1148	21	show	show	VERB
bam-7218	1148	22	reduced	reduced	ADJ
bam-7218	1148	23	levels	level	NOUN
bam-7218	1148	24	of	of	ADP
bam-7218	1148	25	myosin	myosin	PROPN
bam-7218	1148	26	heavy	heavy	PROPN
bam-7218	1148	27	chain	chain	NOUN
bam-7218	1148	28	(	(	PUNCT
bam-7218	1148	29	myhc	myhc	PROPN
bam-7218	1148	30	)	)	PUNCT
bam-7218	1148	31	,	,	PUNCT
bam-7218	1148	32	and	and	CCONJ
bam-7218	1148	33	we	we	PRON
bam-7218	1148	34	found	find	VERB
bam-7218	1148	35	that	that	SCONJ
bam-7218	1148	36	sec	sec	PROPN
bam-7218	1148	37	protect	protect	NOUN
bam-7218	1148	38	against	against	ADP
bam-7218	1148	39	loss	loss	NOUN
bam-7218	1148	40	of	of	ADP
bam-7218	1148	41	myhc	myhc	NOUN
bam-7218	1148	42	in	in	ADP
bam-7218	1148	43	both	both	DET
bam-7218	1148	44	conditions	condition	NOUN
bam-7218	1148	45	in	in	ADP
bam-7218	1148	46	a	a	DET
bam-7218	1148	47	dose	dose	NOUN
bam-7218	1148	48	-	-	PUNCT
bam-7218	1148	49	dependent	dependent	ADJ
bam-7218	1148	50	manner	manner	NOUN
bam-7218	1148	51	,	,	PUNCT
bam-7218	1148	52	high	high	ADJ
bam-7218	1148	53	numbers	number	NOUN
bam-7218	1148	54	of	of	ADP
bam-7218	1148	55	sec	sec	PROPN
bam-7218	1148	56	being	be	AUX
bam-7218	1148	57	the	the	DET
bam-7218	1148	58	most	most	ADV
bam-7218	1148	59	efficacious	efficacious	ADJ
bam-7218	1148	60	.	.	PUNCT
bam-7218	1149	1	moreover	moreover	ADV
bam-7218	1149	2	,	,	PUNCT
bam-7218	1149	3	we	we	PRON
bam-7218	1149	4	demonstrated	demonstrate	VERB
bam-7218	1149	5	that	that	SCONJ
bam-7218	1149	6	,	,	PUNCT
bam-7218	1149	7	as	as	ADP
bam-7218	1149	8	for	for	ADP
bam-7218	1149	9	mdx	mdx	PROPN
bam-7218	1149	10	myotubes	myotube	NOUN
bam-7218	1149	11	/	/	SYM
bam-7218	1149	12	myofibers	myofiber	NOUN
bam-7218	1149	13	,	,	PUNCT
bam-7218	1149	14	2	2	NUM
bam-7218	1149	15	sec	sec	PROPN
bam-7218	1149	16	are	be	AUX
bam-7218	1149	17	able	able	ADJ
bam-7218	1149	18	to	to	PART
bam-7218	1149	19	induce	induce	VERB
bam-7218	1149	20	utrophin	utrophin	ADJ
bam-7218	1149	21	expression	expression	NOUN
bam-7218	1149	22	in	in	ADP
bam-7218	1149	23	myotubes	myotube	NOUN
bam-7218	1149	24	from	from	ADP
bam-7218	1149	25	grmd	grmd	PROPN
bam-7218	1149	26	(	(	PUNCT
bam-7218	1149	27	golden	golden	ADJ
bam-7218	1149	28	retriever	retriever	NOUN
bam-7218	1149	29	muscular	muscular	ADJ
bam-7218	1149	30	dystrophy	dystrophy	NOUN
bam-7218	1149	31	)	)	PUNCT
bam-7218	1149	32	dogs	dog	NOUN
bam-7218	1149	33	and	and	CCONJ
bam-7218	1149	34	dystrophic	dystrophic	ADJ
bam-7218	1149	35	humans	human	NOUN
bam-7218	1149	36	.	.	PUNCT
bam-7218	1150	1	our	our	PRON
bam-7218	1150	2	data	datum	NOUN
bam-7218	1150	3	further	far	ADV
bam-7218	1150	4	support	support	VERB
bam-7218	1150	5	the	the	DET
bam-7218	1150	6	use	use	NOUN
bam-7218	1150	7	of	of	ADP
bam-7218	1150	8	microencapsulated	microencapsulate	VERB
bam-7218	1150	9	sec	sec	PROPN
bam-7218	1150	10	for	for	ADP
bam-7218	1150	11	treatment	treatment	NOUN
bam-7218	1150	12	of	of	ADP
bam-7218	1150	13	dmd	dmd	NOUN
bam-7218	1150	14	patients	patient	NOUN
bam-7218	1150	15	.	.	PUNCT
bam-7218	1151	1	references	reference	NOUN
bam-7218	1151	2	:	:	PUNCT
bam-7218	1151	3	1	1	X
bam-7218	1151	4	.	.	X
bam-7218	1151	5	mital	mital	NOUN
bam-7218	1151	6	et	et	PROPN
bam-7218	1151	7	al	al	PROPN
bam-7218	1151	8	.	.	PROPN
bam-7218	1152	1	(	(	PUNCT
bam-7218	1152	2	2010	2010	NUM
bam-7218	1152	3	)	)	PUNCT
bam-7218	1152	4	immunoprotective	immunoprotective	ADJ
bam-7218	1152	5	sertoli	sertoli	NOUN
bam-7218	1152	6	cells	cell	NOUN
bam-7218	1152	7	:	:	PUNCT
bam-7218	1152	8	making	make	VERB
bam-7218	1152	9	allogeneic	allogeneic	ADJ
bam-7218	1152	10	and	and	CCONJ
bam-7218	1152	11	xenogeneic	xenogeneic	VERB
bam-7218	1152	12	transplantation	transplantation	NOUN
bam-7218	1152	13	feasible	feasible	ADJ
bam-7218	1152	14	.	.	PUNCT
bam-7218	1153	1	reproduction	reproduction	NOUN
bam-7218	1153	2	139	139	NUM
bam-7218	1153	3	:	:	PUNCT
bam-7218	1153	4	495	495	NUM
bam-7218	1153	5	-	-	SYM
bam-7218	1153	6	504	504	NUM
bam-7218	1153	7	.	.	PUNCT
bam-7218	1154	1	2	2	NUM
bam-7218	1154	2	.	.	NUM
bam-7218	1154	3	chiappalupi	chiappalupi	PROPN
bam-7218	1154	4	et	et	PROPN
bam-7218	1154	5	al	al	PROPN
bam-7218	1154	6	.	.	PUNCT
bam-7218	1155	1	(	(	PUNCT
bam-7218	1155	2	2016	2016	NUM
bam-7218	1155	3	)	)	PUNCT
bam-7218	1155	4	intraperitoneal	intraperitoneal	ADJ
bam-7218	1155	5	injection	injection	NOUN
bam-7218	1155	6	of	of	ADP
bam-7218	1155	7	microencapsulated	microencapsulate	VERB
bam-7218	1155	8	sertoli	sertoli	NOUN
bam-7218	1155	9	cells	cell	NOUN
bam-7218	1155	10	restores	restore	VERB
bam-7218	1155	11	muscle	muscle	NOUN
bam-7218	1155	12	morphology	morphology	NOUN
bam-7218	1155	13	and	and	CCONJ
bam-7218	1155	14	performance	performance	NOUN
bam-7218	1155	15	in	in	ADP
bam-7218	1155	16	dystrophic	dystrophic	ADJ
bam-7218	1155	17	mice	mouse	NOUN
bam-7218	1155	18	.	.	PUNCT
bam-7218	1156	1	biomaterials	biomaterial	NOUN
bam-7218	1156	2	75	75	NUM
bam-7218	1156	3	:	:	PUNCT
bam-7218	1156	4	313	313	NUM
bam-7218	1156	5	-	-	SYM
bam-7218	1156	6	26	26	NUM
bam-7218	1156	7	.	.	PUNCT
bam-7218	1157	1	p.30	p.30	PROPN
bam-7218	1157	2	creatine	creatine	PROPN
bam-7218	1157	3	preserves	preserve	VERB
bam-7218	1157	4	the	the	DET
bam-7218	1157	5	myogenic	myogenic	ADJ
bam-7218	1157	6	capacity	capacity	NOUN
bam-7218	1157	7	of	of	ADP
bam-7218	1157	8	oxidant	oxidant	NOUN
bam-7218	1157	9	-	-	PUNCT
bam-7218	1157	10	stressed	stressed	ADJ
bam-7218	1157	11	c2c12	c2c12	PROPN
bam-7218	1157	12	myoblasts	myoblast	NOUN
bam-7218	1157	13	through	through	ADP
bam-7218	1157	14	mitochondrially	mitochondrially	ADV
bam-7218	1157	15	-	-	PUNCT
bam-7218	1157	16	targeted	target	VERB
bam-7218	1157	17	mechanisms	mechanism	NOUN
bam-7218	1157	18	elena	elena	PROPN
bam-7218	1157	19	barbieri	barbieri	PROPN
bam-7218	1157	20	(	(	PUNCT
bam-7218	1157	21	a	a	PROPN
bam-7218	1157	22	)	)	PUNCT
bam-7218	1157	23	,	,	PUNCT
bam-7218	1157	24	cinzia	cinzia	PROPN
bam-7218	1157	25	calcabrini	calcabrini	PROPN
bam-7218	1157	26	(	(	PUNCT
bam-7218	1157	27	a	a	DET
bam-7218	1157	28	,	,	PUNCT
bam-7218	1157	29	b	b	NOUN
bam-7218	1157	30	)	)	PUNCT
bam-7218	1157	31	,	,	PUNCT
bam-7218	1157	32	carmela	carmela	PROPN
bam-7218	1157	33	fimognari	fimognari	PROPN
bam-7218	1157	34	(	(	PUNCT
bam-7218	1157	35	b	b	NOUN
bam-7218	1157	36	)	)	PUNCT
bam-7218	1157	37	,	,	PUNCT
bam-7218	1157	38	piero	piero	PROPN
bam-7218	1157	39	sestili	sestili	PROPN
bam-7218	1157	40	(	(	PUNCT
bam-7218	1157	41	a	a	NOUN
bam-7218	1157	42	)	)	PUNCT
bam-7218	1157	43	(	(	PUNCT
bam-7218	1157	44	a	a	X
bam-7218	1157	45	)	)	PUNCT
bam-7218	1157	46	dept	dept	NOUN
bam-7218	1157	47	of	of	ADP
bam-7218	1157	48	biomolecular	biomolecular	ADJ
bam-7218	1157	49	sciences	science	NOUN
bam-7218	1157	50	,	,	PUNCT
bam-7218	1157	51	university	university	NOUN
bam-7218	1157	52	of	of	ADP
bam-7218	1157	53	urbino	urbino	PROPN
bam-7218	1157	54	carlo	carlo	PROPN
bam-7218	1157	55	bo	bo	PROPN
bam-7218	1157	56	,	,	PUNCT
bam-7218	1157	57	italy	italy	PROPN
bam-7218	1157	58	;	;	PUNCT
bam-7218	1157	59	(	(	PUNCT
bam-7218	1157	60	b	b	X
bam-7218	1157	61	)	)	PUNCT
bam-7218	1157	62	dept	dept	NOUN
bam-7218	1157	63	for	for	ADP
bam-7218	1157	64	life	life	NOUN
bam-7218	1157	65	quality	quality	NOUN
bam-7218	1157	66	studies	study	NOUN
bam-7218	1157	67	,	,	PUNCT
bam-7218	1157	68	alma	alma	NOUN
bam-7218	1157	69	mater	mater	NOUN
bam-7218	1157	70	studiorum	studiorum	PROPN
bam-7218	1157	71	-	-	PUNCT
bam-7218	1157	72	university	university	NOUN
bam-7218	1157	73	of	of	ADP
bam-7218	1157	74	bologna	bologna	PROPN
bam-7218	1157	75	,	,	PUNCT
bam-7218	1157	76	rimini	rimini	PROPN
bam-7218	1157	77	,	,	PUNCT
bam-7218	1157	78	italy	italy	PROPN
bam-7218	1157	79	.	.	PUNCT
bam-7218	1158	1	email	email	NOUN
bam-7218	1158	2	:	:	PUNCT
bam-7218	1158	3	piero.sestili@uniurb.it	piero.sestili@uniurb.it	PROPN
bam-7218	1158	4	creatine	creatine	PROPN
bam-7218	1158	5	(	(	PUNCT
bam-7218	1158	6	cr	cr	NOUN
bam-7218	1158	7	)	)	PUNCT
bam-7218	1158	8	is	be	AUX
bam-7218	1158	9	a	a	DET
bam-7218	1158	10	nutritional	nutritional	ADJ
bam-7218	1158	11	supplement	supplement	NOUN
bam-7218	1158	12	promoting	promote	VERB
bam-7218	1158	13	a	a	DET
bam-7218	1158	14	number	number	NOUN
bam-7218	1158	15	of	of	ADP
bam-7218	1158	16	health	health	NOUN
bam-7218	1158	17	benefits	benefit	NOUN
bam-7218	1158	18	,	,	PUNCT
bam-7218	1158	19	whose	whose	DET
bam-7218	1158	20	use	use	NOUN
bam-7218	1158	21	is	be	AUX
bam-7218	1158	22	spreading	spread	VERB
bam-7218	1158	23	in	in	ADP
bam-7218	1158	24	the	the	DET
bam-7218	1158	25	prevention	prevention	NOUN
bam-7218	1158	26	of	of	ADP
bam-7218	1158	27	muscle	muscle	NOUN
bam-7218	1158	28	aging	aging	NOUN
bam-7218	1158	29	and	and	CCONJ
bam-7218	1158	30	treatment	treatment	NOUN
bam-7218	1158	31	of	of	ADP
bam-7218	1158	32	neuromuscular	neuromuscular	ADJ
bam-7218	1158	33	maladies	malady	NOUN
bam-7218	1158	34	(	(	PUNCT
bam-7218	1158	35	wallimann	wallimann	NOUN
bam-7218	1158	36	,	,	PUNCT
bam-7218	1158	37	2007	2007	NUM
bam-7218	1158	38	)	)	PUNCT
bam-7218	1158	39	.	.	PUNCT
bam-7218	1159	1	indeed	indeed	ADV
bam-7218	1159	2	cr	cr	PROPN
bam-7218	1159	3	has	have	AUX
bam-7218	1159	4	been	be	AUX
bam-7218	1159	5	shown	show	VERB
bam-7218	1159	6	to	to	PART
bam-7218	1159	7	be	be	AUX
bam-7218	1159	8	beneficial	beneficial	ADJ
bam-7218	1159	9	in	in	ADP
bam-7218	1159	10	disease	disease	NOUN
bam-7218	1159	11	-	-	PUNCT
bam-7218	1159	12	induced	induce	VERB
bam-7218	1159	13	muscle	muscle	NOUN
bam-7218	1159	14	atrophy	atrophy	NOUN
bam-7218	1159	15	,	,	PUNCT
bam-7218	1159	16	improve	improve	VERB
bam-7218	1159	17	rehabilitation	rehabilitation	NOUN
bam-7218	1159	18	and	and	CCONJ
bam-7218	1159	19	afford	afford	VERB
bam-7218	1159	20	mild	mild	ADJ
bam-7218	1159	21	antioxidant	antioxidant	ADJ
bam-7218	1159	22	activity	activity	NOUN
bam-7218	1159	23	(	(	PUNCT
bam-7218	1159	24	tarnopolsky	tarnopolsky	NOUN
bam-7218	1159	25	,	,	PUNCT
bam-7218	1159	26	2011	2011	NUM
bam-7218	1159	27	)	)	PUNCT
bam-7218	1159	28	.	.	PUNCT
bam-7218	1160	1	the	the	DET
bam-7218	1160	2	beneficial	beneficial	ADJ
bam-7218	1160	3	effects	effect	NOUN
bam-7218	1160	4	of	of	ADP
bam-7218	1160	5	its	its	PRON
bam-7218	1160	6	supplementation	supplementation	NOUN
bam-7218	1160	7	are	be	AUX
bam-7218	1160	8	likely	likely	ADJ
bam-7218	1160	9	to	to	PART
bam-7218	1160	10	derive	derive	VERB
bam-7218	1160	11	from	from	ADP
bam-7218	1160	12	pleiotropic	pleiotropic	ADJ
bam-7218	1160	13	interactions	interaction	NOUN
bam-7218	1160	14	.	.	PUNCT
bam-7218	1161	1	in	in	ADP
bam-7218	1161	2	accord	accord	NOUN
bam-7218	1161	3	with	with	ADP
bam-7218	1161	4	this	this	DET
bam-7218	1161	5	notion	notion	NOUN
bam-7218	1161	6	,	,	PUNCT
bam-7218	1161	7	we	we	PRON
bam-7218	1161	8	previously	previously	ADV
bam-7218	1161	9	demonstrated	demonstrate	VERB
bam-7218	1161	10	that	that	PRON
bam-7218	1161	11	multiple	multiple	ADJ
bam-7218	1161	12	,	,	PUNCT
bam-7218	1161	13	pleiotropic	pleiotropic	ADJ
bam-7218	1161	14	effects	effect	NOUN
bam-7218	1161	15	account	account	VERB
bam-7218	1161	16	for	for	ADP
bam-7218	1161	17	the	the	DET
bam-7218	1161	18	capacity	capacity	NOUN
bam-7218	1161	19	of	of	ADP
bam-7218	1161	20	cr	cr	NOUN
bam-7218	1161	21	to	to	PART
bam-7218	1161	22	prevent	prevent	VERB
bam-7218	1161	23	the	the	DET
bam-7218	1161	24	differentiation	differentiation	NOUN
bam-7218	1161	25	arrest	arrest	NOUN
bam-7218	1161	26	caused	cause	VERB
bam-7218	1161	27	by	by	ADP
bam-7218	1161	28	oxidative	oxidative	ADJ
bam-7218	1161	29	stress	stress	NOUN
bam-7218	1161	30	in	in	ADP
bam-7218	1161	31	c2c12	c2c12	PROPN
bam-7218	1161	32	myoblasts	myoblast	NOUN
bam-7218	1161	33	,	,	PUNCT
bam-7218	1161	34	namely	namely	ADV
bam-7218	1161	35	:	:	PUNCT
bam-7218	1161	36	increased	increase	VERB
bam-7218	1161	37	expression	expression	NOUN
bam-7218	1161	38	of	of	ADP
bam-7218	1161	39	mailto:franc.rossi@uniroma1.it	mailto:franc.rossi@uniroma1.it	PROPN
bam-7218	1161	40	mailto:laurasalvadori1988@gmail.com	mailto:laurasalvadori1988@gmail.com	PROPN
bam-7218	1161	41	mailto:piero.sestili@uniurb.it	mailto:piero.sestili@uniurb.it	PROPN
bam-7218	1161	42	14	14	NUM
bam-7218	1161	43	th	th	NOUN
bam-7218	1161	44	iiim	iiim	NOUN
bam-7218	1161	45	meeting	meeting	NOUN
bam-7218	1161	46	,	,	PUNCT
bam-7218	1161	47	assisi	assisi	PROPN
bam-7218	1161	48	,	,	PUNCT
bam-7218	1161	49	italy	italy	PROPN
bam-7218	1161	50	october	october	PROPN
bam-7218	1161	51	12	12	NUM
bam-7218	1161	52	-	-	SYM
bam-7218	1161	53	15	15	NUM
bam-7218	1161	54	2017	2017	NUM
bam-7218	1161	55	eur	eur	PROPN
bam-7218	1161	56	j	j	PROPN
bam-7218	1161	57	transl	transl	PROPN
bam-7218	1161	58	myol	myol	ADV
bam-7218	1161	59	27	27	NUM
bam-7218	1161	60	(	(	PUNCT
bam-7218	1161	61	4	4	NUM
bam-7218	1161	62	):	):	SYM
bam-7218	1161	63	185	185	NUM
bam-7218	1161	64	-	-	SYM
bam-7218	1161	65	224	224	NUM
bam-7218	1161	66	221	221	NUM
bam-7218	1161	67	muscle	muscle	NOUN
bam-7218	1161	68	regulatory	regulatory	ADJ
bam-7218	1161	69	factors	factor	NOUN
bam-7218	1161	70	mrna	mrna	NOUN
bam-7218	1161	71	,	,	PUNCT
bam-7218	1161	72	antioxidant	antioxidant	ADJ
bam-7218	1161	73	activity	activity	NOUN
bam-7218	1161	74	,	,	PUNCT
bam-7218	1161	75	amelioration	amelioration	NOUN
bam-7218	1161	76	of	of	ADP
bam-7218	1161	77	energy	energy	NOUN
bam-7218	1161	78	status	status	NOUN
bam-7218	1161	79	and	and	CCONJ
bam-7218	1161	80	preservation	preservation	NOUN
bam-7218	1161	81	of	of	ADP
bam-7218	1161	82	mitochondrial	mitochondrial	ADJ
bam-7218	1161	83	damage	damage	NOUN
bam-7218	1161	84	(	(	PUNCT
bam-7218	1161	85	sestili	sestili	NOUN
bam-7218	1161	86	,	,	PUNCT
bam-7218	1161	87	2015	2015	NUM
bam-7218	1161	88	)	)	PUNCT
bam-7218	1161	89	.	.	PUNCT
bam-7218	1162	1	given	give	VERB
bam-7218	1162	2	the	the	DET
bam-7218	1162	3	importance	importance	NOUN
bam-7218	1162	4	of	of	ADP
bam-7218	1162	5	mitochondria	mitochondria	NOUN
bam-7218	1162	6	in	in	ADP
bam-7218	1162	7	supporting	support	VERB
bam-7218	1162	8	the	the	DET
bam-7218	1162	9	myogenic	myogenic	ADJ
bam-7218	1162	10	process	process	NOUN
bam-7218	1162	11	,	,	PUNCT
bam-7218	1162	12	here	here	ADV
bam-7218	1162	13	we	we	PRON
bam-7218	1162	14	further	far	ADV
bam-7218	1162	15	explored	explore	VERB
bam-7218	1162	16	morphologically	morphologically	ADV
bam-7218	1162	17	,	,	PUNCT
bam-7218	1162	18	cytofluorimetrically	cytofluorimetrically	ADV
bam-7218	1162	19	and	and	CCONJ
bam-7218	1162	20	biochemically	biochemically	ADV
bam-7218	1162	21	the	the	DET
bam-7218	1162	22	protective	protective	ADJ
bam-7218	1162	23	effects	effect	NOUN
bam-7218	1162	24	of	of	ADP
bam-7218	1162	25	cr	cr	NOUN
bam-7218	1162	26	on	on	ADP
bam-7218	1162	27	the	the	DET
bam-7218	1162	28	structure	structure	NOUN
bam-7218	1162	29	,	,	PUNCT
bam-7218	1162	30	function	function	NOUN
bam-7218	1162	31	and	and	CCONJ
bam-7218	1162	32	networking	networking	NOUN
bam-7218	1162	33	of	of	ADP
bam-7218	1162	34	these	these	DET
bam-7218	1162	35	organelles	organelle	NOUN
bam-7218	1162	36	in	in	ADP
bam-7218	1162	37	c2c12	c2c12	PROPN
bam-7218	1162	38	cells	cell	NOUN
bam-7218	1162	39	differentiating	differentiate	VERB
bam-7218	1162	40	under	under	ADP
bam-7218	1162	41	oxidative	oxidative	ADJ
bam-7218	1162	42	stressing	stress	VERB
bam-7218	1162	43	conditions	condition	NOUN
bam-7218	1162	44	(	(	PUNCT
bam-7218	1162	45	acute	acute	ADJ
bam-7218	1162	46	exposure	exposure	NOUN
bam-7218	1162	47	to	to	ADP
bam-7218	1162	48	0.3	0.3	NUM
bam-7218	1162	49	mm	mm	NUM
bam-7218	1162	50	h2o2	h2o2	PROPN
bam-7218	1162	51	)	)	PUNCT
bam-7218	1162	52	;	;	PUNCT
bam-7218	1162	53	the	the	DET
bam-7218	1162	54	effects	effect	NOUN
bam-7218	1162	55	on	on	ADP
bam-7218	1162	56	the	the	DET
bam-7218	1162	57	energy	energy	NOUN
bam-7218	1162	58	sensor	sensor	NOUN
bam-7218	1162	59	ampk	ampk	NOUN
bam-7218	1162	60	,	,	PUNCT
bam-7218	1162	61	on	on	ADP
bam-7218	1162	62	pgc-1α	pgc-1α	NOUN
bam-7218	1162	63	,	,	PUNCT
bam-7218	1162	64	which	which	PRON
bam-7218	1162	65	is	be	AUX
bam-7218	1162	66	involved	involve	VERB
bam-7218	1162	67	in	in	ADP
bam-7218	1162	68	mitochondrial	mitochondrial	ADJ
bam-7218	1162	69	biogenesis	biogenesis	NOUN
bam-7218	1162	70	and	and	CCONJ
bam-7218	1162	71	its	its	PRON
bam-7218	1162	72	downstream	downstream	ADJ
bam-7218	1162	73	effector	effector	NOUN
bam-7218	1162	74	tfam	tfam	NOUN
bam-7218	1162	75	were	be	AUX
bam-7218	1162	76	also	also	ADV
bam-7218	1162	77	investigated	investigate	VERB
bam-7218	1162	78	.	.	PUNCT
bam-7218	1163	1	our	our	PRON
bam-7218	1163	2	results	result	NOUN
bam-7218	1163	3	indicate	indicate	VERB
bam-7218	1163	4	that	that	SCONJ
bam-7218	1163	5	damage	damage	NOUN
bam-7218	1163	6	to	to	ADP
bam-7218	1163	7	mitochondria	mitochondria	PROPN
bam-7218	1163	8	is	be	AUX
bam-7218	1163	9	crucial	crucial	ADJ
bam-7218	1163	10	in	in	ADP
bam-7218	1163	11	the	the	DET
bam-7218	1163	12	differentation	differentation	NOUN
bam-7218	1163	13	imbalance	imbalance	NOUN
bam-7218	1163	14	caused	cause	VERB
bam-7218	1163	15	by	by	ADP
bam-7218	1163	16	oxidative	oxidative	ADJ
bam-7218	1163	17	stress	stress	NOUN
bam-7218	1163	18	and	and	CCONJ
bam-7218	1163	19	that	that	SCONJ
bam-7218	1163	20	the	the	DET
bam-7218	1163	21	cr	cr	PROPN
bam-7218	1163	22	-	-	PUNCT
bam-7218	1163	23	prevention	prevention	NOUN
bam-7218	1163	24	of	of	ADP
bam-7218	1163	25	these	these	DET
bam-7218	1163	26	injuries	injury	NOUN
bam-7218	1163	27	is	be	AUX
bam-7218	1163	28	invariably	invariably	ADV
bam-7218	1163	29	associated	associate	VERB
bam-7218	1163	30	with	with	ADP
bam-7218	1163	31	the	the	DET
bam-7218	1163	32	recovery	recovery	NOUN
bam-7218	1163	33	of	of	ADP
bam-7218	1163	34	the	the	DET
bam-7218	1163	35	normal	normal	ADJ
bam-7218	1163	36	myogenic	myogenic	ADJ
bam-7218	1163	37	capacity	capacity	NOUN
bam-7218	1163	38	.	.	PUNCT
bam-7218	1164	1	we	we	PRON
bam-7218	1164	2	also	also	ADV
bam-7218	1164	3	found	find	VERB
bam-7218	1164	4	that	that	SCONJ
bam-7218	1164	5	cractivates	cractivate	VERB
bam-7218	1164	6	ampk	ampk	NOUN
bam-7218	1164	7	and	and	CCONJ
bam-7218	1164	8	induces	induce	VERB
bam-7218	1164	9	an	an	DET
bam-7218	1164	10	up	up	ADJ
bam-7218	1164	11	-	-	PUNCT
bam-7218	1164	12	regulation	regulation	NOUN
bam-7218	1164	13	of	of	ADP
bam-7218	1164	14	pgc-1α	pgc-1α	NOUN
bam-7218	1164	15	expression	expression	NOUN
bam-7218	1164	16	,	,	PUNCT
bam-7218	1164	17	two	two	NUM
bam-7218	1164	18	events	event	NOUN
bam-7218	1164	19	which	which	PRON
bam-7218	1164	20	are	be	AUX
bam-7218	1164	21	likely	likely	ADJ
bam-7218	1164	22	to	to	PART
bam-7218	1164	23	contribute	contribute	VERB
bam-7218	1164	24	to	to	ADP
bam-7218	1164	25	the	the	DET
bam-7218	1164	26	protection	protection	NOUN
bam-7218	1164	27	of	of	ADP
bam-7218	1164	28	mitochondrial	mitochondrial	ADJ
bam-7218	1164	29	quality	quality	NOUN
bam-7218	1164	30	and	and	CCONJ
bam-7218	1164	31	function	function	NOUN
bam-7218	1164	32	.	.	PUNCT
bam-7218	1165	1	references	reference	NOUN
bam-7218	1165	2	:	:	PUNCT
bam-7218	1165	3	sestili	sestili	PROPN
bam-7218	1165	4	et	et	PROPN
bam-7218	1165	5	al	al	PROPN
bam-7218	1165	6	.	.	PROPN
bam-7218	1166	1	(	(	PUNCT
bam-7218	1166	2	2015	2015	NUM
bam-7218	1166	3	)	)	PUNCT
bam-7218	1166	4	mini	mini	NOUN
bam-7218	1166	5	rev	rev	X
bam-7218	1166	6	med	med	PROPN
bam-7218	1166	7	chem	chem	NOUN
bam-7218	1166	8	.	.	PUNCT
bam-7218	1167	1	16	16	NUM
bam-7218	1167	2	,	,	PUNCT
bam-7218	1167	3	4	4	NUM
bam-7218	1167	4	-	-	SYM
bam-7218	1167	5	11	11	NUM
bam-7218	1167	6	.	.	PUNCT
bam-7218	1168	1	tarnopolsky	tarnopolsky	NOUN
bam-7218	1168	2	(	(	PUNCT
bam-7218	1168	3	2011	2011	NUM
bam-7218	1168	4	)	)	PUNCT
bam-7218	1168	5	amino	amino	ADJ
bam-7218	1168	6	acids	acid	NOUN
bam-7218	1168	7	40	40	NUM
bam-7218	1168	8	,	,	PUNCT
bam-7218	1168	9	13971407	13971407	NUM
bam-7218	1168	10	.	.	PUNCT
bam-7218	1169	1	wallimann	wallimann	PROPN
bam-7218	1169	2	(	(	PUNCT
bam-7218	1169	3	2007	2007	NUM
bam-7218	1169	4	)	)	PUNCT
bam-7218	1169	5	sub	sub	ADJ
bam-7218	1169	6	-	-	ADJ
bam-7218	1169	7	cell	cell	ADJ
bam-7218	1169	8	biochem	biochem	NOUN
bam-7218	1169	9	.	.	PUNCT
bam-7218	1170	1	46	46	NUM
bam-7218	1170	2	,	,	PUNCT
bam-7218	1170	3	1	1	NUM
bam-7218	1170	4	-	-	SYM
bam-7218	1170	5	16	16	NUM
bam-7218	1170	6	.	.	PUNCT
bam-7218	1171	1	p.	p.	NOUN
bam-7218	1171	2	31	31	NUM
bam-7218	1171	3	epigenetic	epigenetic	ADJ
bam-7218	1171	4	and	and	CCONJ
bam-7218	1171	5	transcriptomic	transcriptomic	ADJ
bam-7218	1171	6	profiling	profiling	NOUN
bam-7218	1171	7	of	of	ADP
bam-7218	1171	8	primary	primary	ADJ
bam-7218	1171	9	muscle	muscle	NOUN
bam-7218	1171	10	cells	cell	NOUN
bam-7218	1171	11	during	during	ADP
bam-7218	1171	12	dmd	dmd	NOUN
bam-7218	1171	13	progression	progression	NOUN
bam-7218	1171	14	and	and	CCONJ
bam-7218	1171	15	hdaci	hdaci	NOUN
bam-7218	1171	16	treatment	treatment	NOUN
bam-7218	1171	17	luca	luca	PROPN
bam-7218	1171	18	tucciarone	tucciarone	NOUN
bam-7218	1171	19	(	(	PUNCT
bam-7218	1171	20	a	a	DET
bam-7218	1171	21	,	,	PUNCT
bam-7218	1171	22	b	b	NOUN
bam-7218	1171	23	)	)	PUNCT
bam-7218	1171	24	,	,	PUNCT
bam-7218	1171	25	francesca	francesca	PROPN
bam-7218	1171	26	lugarini	lugarini	PROPN
bam-7218	1171	27	(	(	PUNCT
bam-7218	1171	28	b	b	NOUN
bam-7218	1171	29	)	)	PUNCT
bam-7218	1171	30	,	,	PUNCT
bam-7218	1171	31	pier	pier	PROPN
bam-7218	1171	32	lorenzo	lorenzo	PROPN
bam-7218	1171	33	puri	puri	PROPN
bam-7218	1171	34	(	(	PUNCT
bam-7218	1171	35	b	b	PROPN
bam-7218	1171	36	,	,	PUNCT
bam-7218	1171	37	c	c	NOUN
bam-7218	1171	38	)	)	PUNCT
bam-7218	1171	39	,	,	PUNCT
bam-7218	1171	40	silvia	silvia	PROPN
bam-7218	1171	41	consalvi	consalvi	PROPN
bam-7218	1171	42	(	(	PUNCT
bam-7218	1171	43	b	b	X
bam-7218	1171	44	,	,	PUNCT
bam-7218	1171	45	c	c	NOUN
bam-7218	1171	46	)	)	PUNCT
bam-7218	1171	47	(	(	PUNCT
bam-7218	1171	48	a	a	DET
bam-7218	1171	49	)	)	PUNCT
bam-7218	1171	50	sapienza	sapienza	PROPN
bam-7218	1171	51	university	university	PROPN
bam-7218	1171	52	of	of	ADP
bam-7218	1171	53	rome	rome	PROPN
bam-7218	1171	54	(	(	PUNCT
bam-7218	1171	55	dahfmo	dahfmo	NOUN
bam-7218	1171	56	/	/	SYM
bam-7218	1171	57	unit	unit	NOUN
bam-7218	1171	58	of	of	ADP
bam-7218	1171	59	histology	histology	NOUN
bam-7218	1171	60	and	and	CCONJ
bam-7218	1171	61	medical	medical	ADJ
bam-7218	1171	62	embryology	embryology	NOUN
bam-7218	1171	63	;	;	PUNCT
bam-7218	1171	64	(	(	PUNCT
bam-7218	1171	65	b	b	X
bam-7218	1171	66	)	)	PUNCT
bam-7218	1171	67	fondazione	fondazione	NOUN
bam-7218	1171	68	santa	santa	PROPN
bam-7218	1171	69	lucia	lucia	PROPN
bam-7218	1171	70	(	(	PUNCT
bam-7218	1171	71	irccs)/development	irccs)/development	ADJ
bam-7218	1171	72	aging	age	VERB
bam-7218	1171	73	and	and	CCONJ
bam-7218	1171	74	regeneration	regeneration	NOUN
bam-7218	1171	75	program	program	NOUN
bam-7218	1171	76	,	,	PUNCT
bam-7218	1171	77	italy	italy	PROPN
bam-7218	1171	78	–	–	PUNCT
bam-7218	1171	79	sanford	sanford	PROPN
bam-7218	1171	80	burnham	burnham	PROPN
bam-7218	1171	81	(	(	PUNCT
bam-7218	1171	82	prebys	prebys	PROPN
bam-7218	1171	83	medical	medical	PROPN
bam-7218	1171	84	discovery	discovery	PROPN
bam-7218	1171	85	institute	institute	PROPN
bam-7218	1171	86	,	,	PUNCT
bam-7218	1171	87	ca	ca	PROPN
bam-7218	1171	88	,	,	PUNCT
bam-7218	1171	89	usa	usa	PROPN
bam-7218	1171	90	)	)	PUNCT
bam-7218	1171	91	.	.	PUNCT
bam-7218	1172	1	email	email	NOUN
bam-7218	1172	2	:	:	PUNCT
bam-7218	1172	3	lucatucciarone@gmail.com	lucatucciarone@gmail.com	X
bam-7218	1173	1	duchenne	duchenne	PROPN
bam-7218	1173	2	muscular	muscular	ADJ
bam-7218	1173	3	dystrophy	dystrophy	NOUN
bam-7218	1173	4	(	(	PUNCT
bam-7218	1173	5	dmd	dmd	NOUN
bam-7218	1173	6	)	)	PUNCT
bam-7218	1173	7	is	be	AUX
bam-7218	1173	8	a	a	DET
bam-7218	1173	9	lethal	lethal	ADJ
bam-7218	1173	10	xlinked	xlinke	VERB
bam-7218	1173	11	disease	disease	NOUN
bam-7218	1173	12	caused	cause	VERB
bam-7218	1173	13	by	by	ADP
bam-7218	1173	14	mutations	mutation	NOUN
bam-7218	1173	15	in	in	ADP
bam-7218	1173	16	the	the	DET
bam-7218	1173	17	dystrophin	dystrophin	ADJ
bam-7218	1173	18	gene	gene	NOUN
bam-7218	1173	19	that	that	PRON
bam-7218	1173	20	progressively	progressively	ADV
bam-7218	1173	21	lead	lead	VERB
bam-7218	1173	22	to	to	ADP
bam-7218	1173	23	severe	severe	ADJ
bam-7218	1173	24	respiratory	respiratory	ADJ
bam-7218	1173	25	and	and	CCONJ
bam-7218	1173	26	cardiac	cardiac	ADJ
bam-7218	1173	27	failure	failure	NOUN
bam-7218	1173	28	that	that	PRON
bam-7218	1173	29	cause	cause	VERB
bam-7218	1173	30	premature	premature	ADJ
bam-7218	1173	31	death	death	NOUN
bam-7218	1173	32	.	.	PUNCT
bam-7218	1174	1	dmd	dmd	PROPN
bam-7218	1174	2	pathogenesis	pathogenesis	NOUN
bam-7218	1174	3	is	be	AUX
bam-7218	1174	4	characterized	characterize	VERB
bam-7218	1174	5	by	by	ADP
bam-7218	1174	6	continuous	continuous	ADJ
bam-7218	1174	7	cycles	cycle	NOUN
bam-7218	1174	8	of	of	ADP
bam-7218	1174	9	muscle	muscle	NOUN
bam-7218	1174	10	contraction	contraction	NOUN
bam-7218	1174	11	/	/	SYM
bam-7218	1174	12	degeneration	degeneration	NOUN
bam-7218	1174	13	.	.	PUNCT
bam-7218	1175	1	at	at	ADP
bam-7218	1175	2	early	early	ADJ
bam-7218	1175	3	stages	stage	NOUN
bam-7218	1175	4	of	of	ADP
bam-7218	1175	5	disease	disease	NOUN
bam-7218	1175	6	,	,	PUNCT
bam-7218	1175	7	muscle	muscle	NOUN
bam-7218	1175	8	degeneration	degeneration	NOUN
bam-7218	1175	9	is	be	AUX
bam-7218	1175	10	counterbalanced	counterbalance	VERB
bam-7218	1175	11	by	by	ADP
bam-7218	1175	12	a	a	DET
bam-7218	1175	13	compensatory	compensatory	ADJ
bam-7218	1175	14	repair	repair	NOUN
bam-7218	1175	15	driven	drive	VERB
bam-7218	1175	16	by	by	ADP
bam-7218	1175	17	muscular	muscular	ADJ
bam-7218	1175	18	stem	stem	NOUN
bam-7218	1175	19	cells	cell	NOUN
bam-7218	1175	20	(	(	PUNCT
bam-7218	1175	21	muscs	musc	NOUN
bam-7218	1175	22	)	)	PUNCT
bam-7218	1175	23	.	.	PUNCT
bam-7218	1176	1	as	as	SCONJ
bam-7218	1176	2	the	the	DET
bam-7218	1176	3	disease	disease	NOUN
bam-7218	1176	4	progresses	progress	VERB
bam-7218	1176	5	,	,	PUNCT
bam-7218	1176	6	the	the	DET
bam-7218	1176	7	regeneration	regeneration	NOUN
bam-7218	1176	8	potential	potential	NOUN
bam-7218	1176	9	is	be	AUX
bam-7218	1176	10	exhausted	exhaust	VERB
bam-7218	1176	11	and	and	CCONJ
bam-7218	1176	12	muscles	muscle	NOUN
bam-7218	1176	13	are	be	AUX
bam-7218	1176	14	replaced	replace	VERB
bam-7218	1176	15	by	by	ADP
bam-7218	1176	16	fibrotic	fibrotic	ADJ
bam-7218	1176	17	scars	scar	NOUN
bam-7218	1176	18	and	and	CCONJ
bam-7218	1176	19	fat	fat	ADJ
bam-7218	1176	20	infiltration	infiltration	NOUN
bam-7218	1176	21	(	(	PUNCT
bam-7218	1176	22	dalkilic	dalkilic	PROPN
bam-7218	1176	23	&	&	CCONJ
bam-7218	1176	24	kunkel	kunkel	PROPN
bam-7218	1176	25	,	,	PUNCT
bam-7218	1176	26	2003	2003	NUM
bam-7218	1176	27	)	)	PUNCT
bam-7218	1176	28	.	.	PUNCT
bam-7218	1177	1	the	the	DET
bam-7218	1177	2	identity	identity	NOUN
bam-7218	1177	3	of	of	ADP
bam-7218	1177	4	the	the	DET
bam-7218	1177	5	cellular	cellular	ADJ
bam-7218	1177	6	source	source	NOUN
bam-7218	1177	7	of	of	ADP
bam-7218	1177	8	fibrosis	fibrosis	NOUN
bam-7218	1177	9	and	and	CCONJ
bam-7218	1177	10	fat	fat	ADJ
bam-7218	1177	11	deposition	deposition	NOUN
bam-7218	1177	12	has	have	AUX
bam-7218	1177	13	been	be	AUX
bam-7218	1177	14	recently	recently	ADV
bam-7218	1177	15	assigned	assign	VERB
bam-7218	1177	16	to	to	ADP
bam-7218	1177	17	fibroadipogenic	fibroadipogenic	ADJ
bam-7218	1177	18	progenitors	progenitor	NOUN
bam-7218	1177	19	(	(	PUNCT
bam-7218	1177	20	faps	fap	NOUN
bam-7218	1177	21	;	;	PUNCT
bam-7218	1177	22	joe	joe	PROPN
bam-7218	1177	23	et	et	PROPN
bam-7218	1177	24	al	al	PROPN
bam-7218	1177	25	.	.	PROPN
bam-7218	1177	26	,	,	PUNCT
bam-7218	1177	27	2010	2010	NUM
bam-7218	1177	28	;	;	PUNCT
bam-7218	1177	29	uezumi	uezumi	PROPN
bam-7218	1177	30	et	et	PROPN
bam-7218	1177	31	al	al	PROPN
bam-7218	1177	32	.	.	PROPN
bam-7218	1177	33	,	,	PUNCT
bam-7218	1177	34	2010	2010	NUM
bam-7218	1177	35	)	)	PUNCT
bam-7218	1177	36	.	.	PUNCT
bam-7218	1178	1	although	although	SCONJ
bam-7218	1178	2	there	there	PRON
bam-7218	1178	3	is	be	VERB
bam-7218	1178	4	currently	currently	ADV
bam-7218	1178	5	no	no	DET
bam-7218	1178	6	available	available	ADJ
bam-7218	1178	7	cure	cure	NOUN
bam-7218	1178	8	for	for	ADP
bam-7218	1178	9	dmd	dmd	NOUN
bam-7218	1178	10	,	,	PUNCT
bam-7218	1178	11	several	several	ADJ
bam-7218	1178	12	therapeutic	therapeutic	ADJ
bam-7218	1178	13	strategies	strategy	NOUN
bam-7218	1178	14	are	be	AUX
bam-7218	1178	15	undergoing	undergo	VERB
bam-7218	1178	16	investigation	investigation	NOUN
bam-7218	1178	17	.	.	PUNCT
bam-7218	1179	1	in	in	ADP
bam-7218	1179	2	this	this	DET
bam-7218	1179	3	context	context	NOUN
bam-7218	1179	4	,	,	PUNCT
bam-7218	1179	5	it	it	PRON
bam-7218	1179	6	is	be	AUX
bam-7218	1179	7	of	of	ADP
bam-7218	1179	8	particular	particular	ADJ
bam-7218	1179	9	interest	interest	NOUN
bam-7218	1179	10	the	the	DET
bam-7218	1179	11	pharmacological	pharmacological	ADJ
bam-7218	1179	12	approach	approach	NOUN
bam-7218	1179	13	based	base	VERB
bam-7218	1179	14	on	on	ADP
bam-7218	1179	15	the	the	DET
bam-7218	1179	16	histone	histone	NOUN
bam-7218	1179	17	deacetylase	deacetylase	NOUN
bam-7218	1179	18	inhibitors	inhibitor	NOUN
bam-7218	1179	19	(	(	PUNCT
bam-7218	1179	20	hdaci	hdaci	NOUN
bam-7218	1179	21	)	)	PUNCT
bam-7218	1179	22	,	,	PUNCT
bam-7218	1179	23	which	which	PRON
bam-7218	1179	24	represent	represent	VERB
bam-7218	1179	25	the	the	DET
bam-7218	1179	26	first	first	ADJ
bam-7218	1179	27	generation	generation	NOUN
bam-7218	1179	28	of	of	ADP
bam-7218	1179	29	epigenetic	epigenetic	ADJ
bam-7218	1179	30	drugs	drug	NOUN
bam-7218	1179	31	used	use	VERB
bam-7218	1179	32	to	to	PART
bam-7218	1179	33	counteract	counteract	VERB
bam-7218	1179	34	the	the	DET
bam-7218	1179	35	dmd	dmd	NOUN
bam-7218	1179	36	progression	progression	NOUN
bam-7218	1179	37	.	.	PUNCT
bam-7218	1180	1	recently	recently	ADV
bam-7218	1180	2	,	,	PUNCT
bam-7218	1180	3	our	our	PRON
bam-7218	1180	4	lab	lab	NOUN
bam-7218	1180	5	has	have	AUX
bam-7218	1180	6	identified	identify	VERB
bam-7218	1180	7	a	a	DET
bam-7218	1180	8	regulatory	regulatory	ADJ
bam-7218	1180	9	network	network	NOUN
bam-7218	1180	10	targeted	target	VERB
bam-7218	1180	11	by	by	ADP
bam-7218	1180	12	hdaci	hdaci	NOUN
bam-7218	1180	13	to	to	PART
bam-7218	1180	14	repress	repress	VERB
bam-7218	1180	15	faps	fap	NOUN
bam-7218	1180	16	differentiation	differentiation	NOUN
bam-7218	1180	17	into	into	ADP
bam-7218	1180	18	pro	pro	ADJ
bam-7218	1180	19	-	-	ADJ
bam-7218	1180	20	fibrotic	fibrotic	ADJ
bam-7218	1180	21	and	and	CCONJ
bam-7218	1180	22	adipogenic	adipogenic	ADJ
bam-7218	1180	23	cells	cell	NOUN
bam-7218	1180	24	,	,	PUNCT
bam-7218	1180	25	while	while	SCONJ
bam-7218	1180	26	enhancing	enhance	VERB
bam-7218	1180	27	their	their	PRON
bam-7218	1180	28	ability	ability	NOUN
bam-7218	1180	29	to	to	PART
bam-7218	1180	30	support	support	VERB
bam-7218	1180	31	muscs	musc	NOUN
bam-7218	1180	32	-	-	PUNCT
bam-7218	1180	33	mediated	mediate	VERB
bam-7218	1180	34	compensatory	compensatory	ADJ
bam-7218	1180	35	regeneration	regeneration	NOUN
bam-7218	1180	36	(	(	PUNCT
bam-7218	1180	37	saccone	saccone	NOUN
bam-7218	1180	38	et	et	PROPN
bam-7218	1180	39	al	al	PROPN
bam-7218	1180	40	.	.	PROPN
bam-7218	1180	41	,	,	PUNCT
bam-7218	1180	42	2014	2014	NUM
bam-7218	1180	43	)	)	PUNCT
bam-7218	1180	44	.	.	PUNCT
bam-7218	1181	1	interestingly	interestingly	ADV
bam-7218	1181	2	hdaci	hdaci	VERB
bam-7218	1181	3	pharmacological	pharmacological	ADJ
bam-7218	1181	4	effect	effect	NOUN
bam-7218	1181	5	is	be	AUX
bam-7218	1181	6	restricted	restrict	VERB
bam-7218	1181	7	to	to	ADP
bam-7218	1181	8	the	the	DET
bam-7218	1181	9	early	early	ADJ
bam-7218	1181	10	stage	stage	NOUN
bam-7218	1181	11	of	of	ADP
bam-7218	1181	12	dmd	dmd	NOUN
bam-7218	1181	13	(	(	PUNCT
bam-7218	1181	14	mozzetta	mozzetta	PROPN
bam-7218	1181	15	et	et	PROPN
bam-7218	1181	16	al	al	PROPN
bam-7218	1181	17	.	.	PROPN
bam-7218	1181	18	2013	2013	NUM
bam-7218	1181	19	)	)	PUNCT
bam-7218	1181	20	.	.	PUNCT
bam-7218	1182	1	the	the	DET
bam-7218	1182	2	mechanism	mechanism	NOUN
bam-7218	1182	3	during	during	ADP
bam-7218	1182	4	the	the	DET
bam-7218	1182	5	aging	aging	NOUN
bam-7218	1182	6	of	of	ADP
bam-7218	1182	7	dmd	dmd	NOUN
bam-7218	1182	8	faps	fap	NOUN
bam-7218	1182	9	that	that	PRON
bam-7218	1182	10	confers	confer	VERB
bam-7218	1182	11	resistance	resistance	NOUN
bam-7218	1182	12	to	to	ADP
bam-7218	1182	13	hdaci	hdaci	NOUN
bam-7218	1182	14	treatment	treatment	NOUN
bam-7218	1182	15	is	be	AUX
bam-7218	1182	16	still	still	ADV
bam-7218	1182	17	unknown	unknown	ADJ
bam-7218	1182	18	.	.	PUNCT
bam-7218	1183	1	the	the	DET
bam-7218	1183	2	aim	aim	NOUN
bam-7218	1183	3	of	of	ADP
bam-7218	1183	4	this	this	DET
bam-7218	1183	5	project	project	NOUN
bam-7218	1183	6	is	be	AUX
bam-7218	1183	7	thus	thus	ADV
bam-7218	1183	8	to	to	PART
bam-7218	1183	9	investigate	investigate	VERB
bam-7218	1183	10	the	the	DET
bam-7218	1183	11	epigenetic	epigenetic	ADJ
bam-7218	1183	12	and	and	CCONJ
bam-7218	1183	13	transcriptomic	transcriptomic	ADJ
bam-7218	1183	14	changes	change	NOUN
bam-7218	1183	15	that	that	PRON
bam-7218	1183	16	leads	lead	VERB
bam-7218	1183	17	faps	fap	NOUN
bam-7218	1183	18	stage	stage	VERB
bam-7218	1183	19	dependent	dependent	ADJ
bam-7218	1183	20	response	response	NOUN
bam-7218	1183	21	to	to	ADP
bam-7218	1183	22	hdaci	hdaci	NOUN
bam-7218	1183	23	.	.	PUNCT
bam-7218	1184	1	by	by	ADP
bam-7218	1184	2	chipseq	chipseq	NOUN
bam-7218	1184	3	bioinformatic	bioinformatic	ADJ
bam-7218	1184	4	analysis	analysis	NOUN
bam-7218	1184	5	of	of	ADP
bam-7218	1184	6	mdx	mdx	PROPN
bam-7218	1184	7	faps	fap	NOUN
bam-7218	1184	8	histone	histone	NOUN
bam-7218	1184	9	acetylation	acetylation	NOUN
bam-7218	1184	10	we	we	PRON
bam-7218	1184	11	uncovered	uncover	VERB
bam-7218	1184	12	an	an	DET
bam-7218	1184	13	indiscriminate	indiscriminate	ADJ
bam-7218	1184	14	histone	histone	NOUN
bam-7218	1184	15	hyperacetylation	hyperacetylation	NOUN
bam-7218	1184	16	at	at	ADP
bam-7218	1184	17	late	late	ADJ
bam-7218	1184	18	stages	stage	NOUN
bam-7218	1184	19	of	of	ADP
bam-7218	1184	20	dmd	dmd	NOUN
bam-7218	1184	21	that	that	PRON
bam-7218	1184	22	is	be	AUX
bam-7218	1184	23	paradoxically	paradoxically	ADV
bam-7218	1184	24	reduced	reduce	VERB
bam-7218	1184	25	by	by	ADP
bam-7218	1184	26	hdaci	hdaci	NOUN
bam-7218	1184	27	treatment	treatment	NOUN
bam-7218	1184	28	.	.	PUNCT
bam-7218	1185	1	this	this	DET
bam-7218	1185	2	data	datum	NOUN
bam-7218	1185	3	could	could	AUX
bam-7218	1185	4	represent	represent	VERB
bam-7218	1185	5	the	the	DET
bam-7218	1185	6	first	first	ADJ
bam-7218	1185	7	evidence	evidence	NOUN
bam-7218	1185	8	of	of	ADP
bam-7218	1185	9	an	an	DET
bam-7218	1185	10	hdaci	hdaci	NOUN
bam-7218	1185	11	counter	counter	ADJ
bam-7218	1185	12	-	-	ADJ
bam-7218	1185	13	active	active	ADJ
bam-7218	1185	14	effect	effect	NOUN
bam-7218	1185	15	at	at	ADP
bam-7218	1185	16	late	late	ADJ
bam-7218	1185	17	stages	stage	NOUN
bam-7218	1185	18	of	of	ADP
bam-7218	1185	19	dmd	dmd	NOUN
bam-7218	1185	20	.	.	NOUN
bam-7218	1185	21	integrating	integrate	VERB
bam-7218	1185	22	various	various	ADJ
bam-7218	1185	23	histone	histone	NOUN
bam-7218	1185	24	modification	modification	NOUN
bam-7218	1185	25	and	and	CCONJ
bam-7218	1185	26	the	the	DET
bam-7218	1185	27	transcriptomic	transcriptomic	ADJ
bam-7218	1185	28	profile	profile	NOUN
bam-7218	1185	29	of	of	ADP
bam-7218	1185	30	faps	fap	NOUN
bam-7218	1185	31	could	could	AUX
bam-7218	1185	32	unveil	unveil	VERB
bam-7218	1185	33	a	a	DET
bam-7218	1185	34	possible	possible	ADJ
bam-7218	1185	35	mechanism	mechanism	NOUN
bam-7218	1185	36	behind	behind	ADP
bam-7218	1185	37	dmd	dmd	NOUN
bam-7218	1185	38	aging	aging	NOUN
bam-7218	1185	39	and	and	CCONJ
bam-7218	1185	40	hdaci	hdaci	NOUN
bam-7218	1185	41	efficacy	efficacy	NOUN
bam-7218	1185	42	at	at	ADP
bam-7218	1185	43	late	late	ADJ
bam-7218	1185	44	stage	stage	NOUN
bam-7218	1185	45	of	of	ADP
bam-7218	1185	46	dmd	dmd	PROPN
bam-7218	1185	47	.	.	PROPN
bam-7218	1185	48	references	reference	NOUN
bam-7218	1185	49	:	:	PUNCT
bam-7218	1185	50	dalkilic	dalkilic	PROPN
bam-7218	1185	51	i	i	PROPN
bam-7218	1185	52	,	,	PUNCT
bam-7218	1185	53	kunkel	kunkel	PROPN
bam-7218	1185	54	lm	lm	PROPN
bam-7218	1185	55	(	(	PUNCT
bam-7218	1185	56	2003	2003	NUM
bam-7218	1185	57	)	)	PUNCT
bam-7218	1185	58	muscular	muscular	ADJ
bam-7218	1185	59	dystrophies	dystrophy	NOUN
bam-7218	1185	60	:	:	PUNCT
bam-7218	1185	61	genes	gene	NOUN
bam-7218	1185	62	to	to	ADP
bam-7218	1185	63	pathogenesis	pathogenesis	NOUN
bam-7218	1185	64	.	.	PUNCT
bam-7218	1186	1	curr	curr	PROPN
bam-7218	1186	2	opin	opin	PROPN
bam-7218	1186	3	genet	genet	PROPN
bam-7218	1186	4	dev	dev	PROPN
bam-7218	1186	5	13	13	NUM
bam-7218	1186	6	:	:	PUNCT
bam-7218	1186	7	231–238	231–238	NUM
bam-7218	1186	8	.	.	PUNCT
bam-7218	1187	1	mozzetta	mozzetta	PROPN
bam-7218	1187	2	c	c	PROPN
bam-7218	1187	3	,	,	PUNCT
bam-7218	1187	4	consalvi	consalvi	PROPN
bam-7218	1187	5	s	s	PROPN
bam-7218	1187	6	,	,	PUNCT
bam-7218	1187	7	saccone	saccone	NOUN
bam-7218	1187	8	et	et	PROPN
bam-7218	1187	9	al	al	PROPN
bam-7218	1187	10	.	.	PROPN
bam-7218	1187	11	,fibroadipogenic	,fibroadipogenic	PUNCT
bam-7218	1187	12	progenitors	progenitor	NOUN
bam-7218	1187	13	mediate	mediate	VERB
bam-7218	1187	14	the	the	DET
bam-7218	1187	15	ability	ability	NOUN
bam-7218	1187	16	of	of	ADP
bam-7218	1187	17	hdac	hdac	NOUN
bam-7218	1187	18	inhibitors	inhibitor	NOUN
bam-7218	1187	19	to	to	PART
bam-7218	1187	20	promote	promote	VERB
bam-7218	1187	21	regeneration	regeneration	NOUN
bam-7218	1187	22	in	in	ADP
bam-7218	1187	23	dystrophic	dystrophic	ADJ
bam-7218	1187	24	muscles	muscle	NOUN
bam-7218	1187	25	of	of	ADP
bam-7218	1187	26	young	young	ADJ
bam-7218	1187	27	,	,	PUNCT
bam-7218	1187	28	but	but	CCONJ
bam-7218	1187	29	not	not	PART
bam-7218	1187	30	old	old	ADJ
bam-7218	1187	31	mdx	mdx	NOUN
bam-7218	1187	32	mice	mouse	NOUN
bam-7218	1187	33	.	.	PUNCT
bam-7218	1188	1	references	reference	NOUN
bam-7218	1188	2	.	.	PUNCT
bam-7218	1189	1	embo	embo	NOUN
bam-7218	1189	2	mol	mol	ADP
bam-7218	1189	3	med	med	PROPN
bam-7218	1189	4	.	.	PUNCT
bam-7218	1190	1	2013	2013	NUM
bam-7218	1190	2	apr;5(4):626	apr;5(4):626	NOUN
bam-7218	1190	3	-	-	NOUN
bam-7218	1190	4	39	39	NUM
bam-7218	1190	5	.	.	PUNCT
bam-7218	1191	1	doi	doi	NOUN
bam-7218	1191	2	:	:	PUNCT
bam-7218	1191	3	10.1002	10.1002	NUM
bam-7218	1191	4	/	/	SYM
bam-7218	1191	5	emmm.201202096	emmm.201202096	PROPN
bam-7218	1191	6	.	.	PUNCT
bam-7218	1192	1	epub	epub	PROPN
bam-7218	1192	2	2013	2013	NUM
bam-7218	1192	3	mar	mar	PROPN
bam-7218	1192	4	18	18	NUM
bam-7218	1192	5	.	.	PUNCT
bam-7218	1193	1	saccone	saccone	PROPN
bam-7218	1193	2	v	v	PROPN
bam-7218	1193	3	,	,	PUNCT
bam-7218	1193	4	consalvi	consalvi	PROPN
bam-7218	1193	5	s	s	PART
bam-7218	1193	6	,	,	PUNCT
bam-7218	1193	7	giordani	giordani	PROPN
bam-7218	1193	8	et	et	PROPN
bam-7218	1193	9	al	al	PROPN
bam-7218	1193	10	ri	ri	PROPN
bam-7218	1193	11	pl	pl	PROPN
bam-7218	1193	12	.	.	PROPN
bam-7218	1193	13	hdacregulated	hdacregulate	VERB
bam-7218	1193	14	myomirs	myomirs	NOUN
bam-7218	1193	15	control	control	NOUN
bam-7218	1193	16	baf60	baf60	VERB
bam-7218	1193	17	variant	variant	ADJ
bam-7218	1193	18	exchange	exchange	NOUN
bam-7218	1193	19	and	and	CCONJ
bam-7218	1193	20	direct	direct	VERB
bam-7218	1193	21	the	the	DET
bam-7218	1193	22	functional	functional	ADJ
bam-7218	1193	23	phenotype	phenotype	NOUN
bam-7218	1193	24	of	of	ADP
bam-7218	1193	25	fibro	fibro	PROPN
bam-7218	1193	26	-	-	PUNCT
bam-7218	1193	27	adipogenic	adipogenic	ADJ
bam-7218	1193	28	progenitors	progenitor	NOUN
bam-7218	1193	29	in	in	ADP
bam-7218	1193	30	dystrophic	dystrophic	ADJ
bam-7218	1193	31	muscles	muscle	NOUN
bam-7218	1193	32	.	.	PUNCT
bam-7218	1194	1	genes	gene	NOUN
bam-7218	1194	2	dev	dev	PROPN
bam-7218	1194	3	.	.	PROPN
bam-7218	1195	1	2014	2014	NUM
bam-7218	1195	2	apr	apr	PROPN
bam-7218	1195	3	15;28(8):841	15;28(8):841	NUM
bam-7218	1195	4	-	-	SYM
bam-7218	1195	5	57	57	NUM
bam-7218	1195	6	.	.	PUNCT
bam-7218	1196	1	doi	doi	NOUN
bam-7218	1196	2	:	:	PUNCT
bam-7218	1196	3	10.1101	10.1101	NUM
bam-7218	1196	4	/	/	SYM
bam-7218	1196	5	gad.234468.113	gad.234468.113	PROPN
bam-7218	1196	6	.	.	PUNCT
bam-7218	1197	1	epub	epub	PROPN
bam-7218	1197	2	2014	2014	NUM
bam-7218	1197	3	mar	mar	PROPN
bam-7218	1197	4	28	28	NUM
bam-7218	1197	5	.	.	PUNCT
bam-7218	1198	1	p.32	p.32	VERB
bam-7218	1198	2	iron	iron	NOUN
bam-7218	1198	3	availability	availability	NOUN
bam-7218	1198	4	and	and	CCONJ
bam-7218	1198	5	recycling	recycling	NOUN
bam-7218	1198	6	regulates	regulate	VERB
bam-7218	1198	7	skeletal	skeletal	ADJ
bam-7218	1198	8	muscle	muscle	NOUN
bam-7218	1198	9	wasting	waste	VERB
bam-7218	1198	10	elisabeth	elisabeth	PROPN
bam-7218	1198	11	wyart	wyart	NOUN
bam-7218	1198	12	(	(	PUNCT
bam-7218	1198	13	a	a	NOUN
bam-7218	1198	14	)	)	PUNCT
bam-7218	1198	15	,	,	PUNCT
bam-7218	1198	16	laure	laure	PROPN
bam-7218	1198	17	bindels	bindel	NOUN
bam-7218	1198	18	(	(	PUNCT
bam-7218	1198	19	b	b	NOUN
bam-7218	1198	20	)	)	PUNCT
bam-7218	1198	21	,	,	PUNCT
bam-7218	1198	22	paolo	paolo	NOUN
bam-7218	1198	23	e	e	PROPN
bam-7218	1198	24	porporato	porporato	NOUN
bam-7218	1198	25	(	(	PUNCT
bam-7218	1198	26	a	a	NOUN
bam-7218	1198	27	)	)	PUNCT
bam-7218	1198	28	a	a	X
bam-7218	1198	29	)	)	PUNCT
bam-7218	1198	30	molecular	molecular	ADJ
bam-7218	1198	31	biotechnology	biotechnology	NOUN
bam-7218	1198	32	center	center	NOUN
bam-7218	1198	33	,	,	PUNCT
bam-7218	1198	34	dept	dept	NOUN
bam-7218	1198	35	of	of	ADP
bam-7218	1198	36	molecular	molecular	ADJ
bam-7218	1198	37	biotechnology	biotechnology	NOUN
bam-7218	1198	38	and	and	CCONJ
bam-7218	1198	39	health	health	NOUN
bam-7218	1198	40	sciences	science	NOUN
bam-7218	1198	41	;	;	PUNCT
bam-7218	1198	42	b)university	b)university	NOUN
bam-7218	1198	43	of	of	ADP
bam-7218	1198	44	louvain	louvain	NOUN
bam-7218	1198	45	(	(	PUNCT
bam-7218	1198	46	ucl	ucl	PROPN
bam-7218	1198	47	)	)	PUNCT
bam-7218	1198	48	medical	medical	ADJ
bam-7218	1198	49	school	school	NOUN
bam-7218	1198	50	,	,	PUNCT
bam-7218	1198	51	brussels	brussels	PROPN
bam-7218	1198	52	,	,	PUNCT
bam-7218	1198	53	belgium	belgium	PROPN
bam-7218	1198	54	.	.	PUNCT
bam-7218	1199	1	email	email	NOUN
bam-7218	1199	2	:	:	PUNCT
bam-7218	1199	3	elisabeth.wyart@unito.it	elisabeth.wyart@unito.it	NOUN
bam-7218	1199	4	iron	iron	NOUN
bam-7218	1199	5	is	be	AUX
bam-7218	1199	6	an	an	DET
bam-7218	1199	7	essential	essential	ADJ
bam-7218	1199	8	metal	metal	NOUN
bam-7218	1199	9	for	for	ADP
bam-7218	1199	10	a	a	DET
bam-7218	1199	11	plethora	plethora	NOUN
bam-7218	1199	12	of	of	ADP
bam-7218	1199	13	biological	biological	ADJ
bam-7218	1199	14	reactions	reaction	NOUN
bam-7218	1199	15	in	in	ADP
bam-7218	1199	16	light	light	NOUN
bam-7218	1199	17	of	of	ADP
bam-7218	1199	18	an	an	DET
bam-7218	1199	19	elevated	elevated	ADJ
bam-7218	1199	20	reactivity	reactivity	NOUN
bam-7218	1199	21	,	,	PUNCT
bam-7218	1199	22	which	which	PRON
bam-7218	1199	23	is	be	AUX
bam-7218	1199	24	also	also	ADV
bam-7218	1199	25	the	the	DET
bam-7218	1199	26	reason	reason	NOUN
bam-7218	1199	27	of	of	ADP
bam-7218	1199	28	its	its	PRON
bam-7218	1199	29	elevated	elevated	ADJ
bam-7218	1199	30	toxicity	toxicity	NOUN
bam-7218	1199	31	when	when	SCONJ
bam-7218	1199	32	it	it	PRON
bam-7218	1199	33	is	be	AUX
bam-7218	1199	34	not	not	PART
bam-7218	1199	35	properly	properly	ADV
bam-7218	1199	36	compartmentalized	compartmentalize	VERB
bam-7218	1199	37	.	.	PUNCT
bam-7218	1200	1	while	while	SCONJ
bam-7218	1200	2	iron	iron	NOUN
bam-7218	1200	3	overload	overload	NOUN
bam-7218	1200	4	is	be	AUX
bam-7218	1200	5	known	know	VERB
bam-7218	1200	6	to	to	PART
bam-7218	1200	7	cause	cause	VERB
bam-7218	1200	8	muscle	muscle	NOUN
bam-7218	1200	9	dysfunction	dysfunction	NOUN
bam-7218	1200	10	,	,	PUNCT
bam-7218	1200	11	we	we	PRON
bam-7218	1200	12	still	still	ADV
bam-7218	1200	13	have	have	VERB
bam-7218	1200	14	a	a	DET
bam-7218	1200	15	limited	limited	ADJ
bam-7218	1200	16	knowledge	knowledge	NOUN
bam-7218	1200	17	of	of	ADP
bam-7218	1200	18	the	the	DET
bam-7218	1200	19	role	role	NOUN
bam-7218	1200	20	played	play	VERB
bam-7218	1200	21	by	by	ADP
bam-7218	1200	22	iron	iron	NOUN
bam-7218	1200	23	deprivation	deprivation	NOUN
bam-7218	1200	24	in	in	ADP
bam-7218	1200	25	the	the	DET
bam-7218	1200	26	pathogenesis	pathogenesis	NOUN
bam-7218	1200	27	of	of	ADP
bam-7218	1200	28	skeletal	skeletal	ADJ
bam-7218	1200	29	muscle	muscle	NOUN
bam-7218	1200	30	atrophy	atrophy	NOUN
bam-7218	1200	31	.	.	PUNCT
bam-7218	1201	1	since	since	SCONJ
bam-7218	1201	2	iron	iron	NOUN
bam-7218	1201	3	is	be	AUX
bam-7218	1201	4	commonly	commonly	ADV
bam-7218	1201	5	limited	limit	VERB
bam-7218	1201	6	in	in	ADP
bam-7218	1201	7	several	several	ADJ
bam-7218	1201	8	systemic	systemic	ADJ
bam-7218	1201	9	diseases	disease	NOUN
bam-7218	1201	10	characterized	characterize	VERB
bam-7218	1201	11	by	by	ADP
bam-7218	1201	12	muscle	muscle	NOUN
bam-7218	1201	13	atrophy	atrophy	NOUN
bam-7218	1201	14	,	,	PUNCT
bam-7218	1201	15	we	we	PRON
bam-7218	1201	16	speculated	speculate	VERB
bam-7218	1201	17	that	that	SCONJ
bam-7218	1201	18	iron	iron	NOUN
bam-7218	1201	19	availability	availability	NOUN
bam-7218	1201	20	might	might	AUX
bam-7218	1201	21	directly	directly	ADV
bam-7218	1201	22	regulate	regulate	VERB
bam-7218	1201	23	skeletal	skeletal	ADJ
bam-7218	1201	24	muscle	muscle	NOUN
bam-7218	1201	25	mass	mass	NOUN
bam-7218	1201	26	homeostasis	homeostasis	NOUN
bam-7218	1201	27	.	.	PUNCT
bam-7218	1202	1	consistently	consistently	ADV
bam-7218	1202	2	,	,	PUNCT
bam-7218	1202	3	iron	iron	NOUN
bam-7218	1202	4	deprivation	deprivation	NOUN
bam-7218	1202	5	in	in	ADP
bam-7218	1202	6	vitro	vitro	X
bam-7218	1202	7	is	be	AUX
bam-7218	1202	8	sufficient	sufficient	ADJ
bam-7218	1202	9	to	to	PART
bam-7218	1202	10	promote	promote	VERB
bam-7218	1202	11	myotubes	myotube	NOUN
bam-7218	1202	12	atrophy	atrophy	NOUN
bam-7218	1202	13	as	as	ADP
bam-7218	1202	14	seen	see	VERB
bam-7218	1202	15	as	as	ADP
bam-7218	1202	16	myotubes	myotube	NOUN
bam-7218	1202	17	thickness	thickness	NOUN
bam-7218	1202	18	reduction	reduction	NOUN
bam-7218	1202	19	and	and	CCONJ
bam-7218	1202	20	atrogenes	atrogene	VERB
bam-7218	1202	21	mailto:lucatucciarone@gmail.com	mailto:lucatucciarone@gmail.com	PROPN
bam-7218	1203	1	mailto:elisabeth.wyart@unito.it	mailto:elisabeth.wyart@unito.it	PROPN
bam-7218	1203	2	14	14	NUM
bam-7218	1203	3	th	th	NOUN
bam-7218	1203	4	iiim	iiim	NOUN
bam-7218	1203	5	meeting	meeting	NOUN
bam-7218	1203	6	,	,	PUNCT
bam-7218	1203	7	assisi	assisi	PROPN
bam-7218	1203	8	,	,	PUNCT
bam-7218	1203	9	italy	italy	PROPN
bam-7218	1203	10	october	october	PROPN
bam-7218	1203	11	12	12	NUM
bam-7218	1203	12	-	-	SYM
bam-7218	1203	13	15	15	NUM
bam-7218	1203	14	2017	2017	NUM
bam-7218	1203	15	eur	eur	PROPN
bam-7218	1203	16	j	j	PROPN
bam-7218	1203	17	transl	transl	PROPN
bam-7218	1203	18	myol	myol	ADV
bam-7218	1203	19	27	27	NUM
bam-7218	1203	20	(	(	PUNCT
bam-7218	1203	21	4	4	NUM
bam-7218	1203	22	):	):	SYM
bam-7218	1203	23	185	185	NUM
bam-7218	1203	24	-	-	SYM
bam-7218	1203	25	224	224	NUM
bam-7218	1203	26	222	222	NUM
bam-7218	1203	27	expression	expression	NOUN
bam-7218	1203	28	.	.	PUNCT
bam-7218	1204	1	datasets	dataset	NOUN
bam-7218	1204	2	analysis	analysis	NOUN
bam-7218	1204	3	indicated	indicate	VERB
bam-7218	1204	4	transferrin	transferrin	NOUN
bam-7218	1204	5	receptor	receptor	NOUN
bam-7218	1204	6	1	1	NUM
bam-7218	1204	7	(	(	PUNCT
bam-7218	1204	8	the	the	DET
bam-7218	1204	9	receptor	receptor	NOUN
bam-7218	1204	10	involved	involve	VERB
bam-7218	1204	11	in	in	ADP
bam-7218	1204	12	transferrin	transferrin	NOUN
bam-7218	1204	13	uptake	uptake	NOUN
bam-7218	1204	14	)	)	PUNCT
bam-7218	1204	15	as	as	ADP
bam-7218	1204	16	one	one	NUM
bam-7218	1204	17	of	of	ADP
bam-7218	1204	18	the	the	DET
bam-7218	1204	19	primary	primary	ADJ
bam-7218	1204	20	targets	target	NOUN
bam-7218	1204	21	to	to	PART
bam-7218	1204	22	be	be	AUX
bam-7218	1204	23	downregulated	downregulate	VERB
bam-7218	1204	24	during	during	ADP
bam-7218	1204	25	muscle	muscle	NOUN
bam-7218	1204	26	atrophy	atrophy	NOUN
bam-7218	1204	27	upon	upon	SCONJ
bam-7218	1204	28	various	various	ADJ
bam-7218	1204	29	stimuli	stimulus	NOUN
bam-7218	1204	30	,	,	PUNCT
bam-7218	1204	31	while	while	SCONJ
bam-7218	1204	32	treatment	treatment	NOUN
bam-7218	1204	33	with	with	ADP
bam-7218	1204	34	conditioned	condition	VERB
bam-7218	1204	35	media	medium	NOUN
bam-7218	1204	36	derived	derive	VERB
bam-7218	1204	37	from	from	ADP
bam-7218	1204	38	cancer	cancer	NOUN
bam-7218	1204	39	cells	cell	NOUN
bam-7218	1204	40	or	or	CCONJ
bam-7218	1204	41	dexamethasone	dexamethasone	NOUN
bam-7218	1204	42	is	be	AUX
bam-7218	1204	43	sufficient	sufficient	ADJ
bam-7218	1204	44	to	to	PART
bam-7218	1204	45	impair	impair	VERB
bam-7218	1204	46	transferrin	transferrin	NOUN
bam-7218	1204	47	recycling	recycling	NOUN
bam-7218	1204	48	in	in	ADP
bam-7218	1204	49	myotubes	myotube	NOUN
bam-7218	1204	50	,	,	PUNCT
bam-7218	1204	51	as	as	ADV
bam-7218	1204	52	well	well	ADV
bam-7218	1204	53	as	as	ADP
bam-7218	1204	54	total	total	ADJ
bam-7218	1204	55	transferrin	transferrin	NOUN
bam-7218	1204	56	receptor	receptor	NOUN
bam-7218	1204	57	protein	protein	NOUN
bam-7218	1204	58	levels	level	NOUN
bam-7218	1204	59	.	.	PUNCT
bam-7218	1205	1	these	these	DET
bam-7218	1205	2	data	datum	NOUN
bam-7218	1205	3	further	far	ADV
bam-7218	1205	4	suggest	suggest	VERB
bam-7218	1205	5	that	that	SCONJ
bam-7218	1205	6	iron	iron	NOUN
bam-7218	1205	7	metabolism	metabolism	NOUN
bam-7218	1205	8	might	might	AUX
bam-7218	1205	9	be	be	AUX
bam-7218	1205	10	directly	directly	ADV
bam-7218	1205	11	involved	involve	VERB
bam-7218	1205	12	in	in	ADP
bam-7218	1205	13	the	the	DET
bam-7218	1205	14	pathogenesis	pathogenesis	NOUN
bam-7218	1205	15	of	of	ADP
bam-7218	1205	16	muscle	muscle	NOUN
bam-7218	1205	17	wasting	waste	VERB
bam-7218	1205	18	.	.	PUNCT
bam-7218	1206	1	implications	implication	NOUN
bam-7218	1206	2	of	of	ADP
bam-7218	1206	3	the	the	DET
bam-7218	1206	4	effects	effect	NOUN
bam-7218	1206	5	of	of	ADP
bam-7218	1206	6	iron	iron	NOUN
bam-7218	1206	7	dysbiosis	dysbiosis	NOUN
bam-7218	1206	8	on	on	ADP
bam-7218	1206	9	mitochondrial	mitochondrial	ADJ
bam-7218	1206	10	metabolism	metabolism	NOUN
bam-7218	1206	11	and	and	CCONJ
bam-7218	1206	12	altered	alter	VERB
bam-7218	1206	13	gene	gene	NOUN
bam-7218	1206	14	expression	expression	NOUN
bam-7218	1206	15	will	will	AUX
bam-7218	1206	16	be	be	AUX
bam-7218	1206	17	discussed	discuss	VERB
bam-7218	1206	18	.	.	PUNCT
bam-7218	1207	1	p.33	p.33	PROPN
bam-7218	1207	2	mcu	mcu	PROPN
bam-7218	1207	3	expression	expression	NOUN
bam-7218	1207	4	levels	level	NOUN
bam-7218	1207	5	and	and	CCONJ
bam-7218	1207	6	mitochondria	mitochondria	NOUN
bam-7218	1207	7	dynamics	dynamic	NOUN
bam-7218	1207	8	in	in	ADP
bam-7218	1207	9	skeletal	skeletal	ADJ
bam-7218	1207	10	muscle	muscle	NOUN
bam-7218	1207	11	of	of	ADP
bam-7218	1207	12	70yrs	70yrs	NUM
bam-7218	1207	13	trained	train	VERB
bam-7218	1207	14	seniors	senior	NOUN
bam-7218	1207	15	sandra	sandra	PROPN
bam-7218	1207	16	zampieri	zampieri	PROPN
bam-7218	1207	17	(	(	PUNCT
bam-7218	1207	18	a	a	DET
bam-7218	1207	19	,	,	PUNCT
bam-7218	1207	20	b	b	NOUN
bam-7218	1207	21	,	,	PUNCT
bam-7218	1207	22	c	c	NOUN
bam-7218	1207	23	)	)	PUNCT
bam-7218	1207	24	,	,	PUNCT
bam-7218	1207	25	cristina	cristina	PROPN
bam-7218	1207	26	mammucari	mammucari	PROPN
bam-7218	1207	27	(	(	PUNCT
bam-7218	1207	28	b	b	NOUN
bam-7218	1207	29	)	)	PUNCT
bam-7218	1207	30	,	,	PUNCT
bam-7218	1208	1	vanina	vanina	NOUN
bam-7218	1208	2	romanello	romanello	INTJ
bam-7218	1208	3	(	(	PUNCT
bam-7218	1208	4	d	d	NOUN
bam-7218	1208	5	)	)	PUNCT
bam-7218	1208	6	,	,	PUNCT
bam-7218	1208	7	laura	laura	NOUN
bam-7218	1208	8	barberi	barberi	PROPN
bam-7218	1208	9	(	(	PUNCT
bam-7218	1208	10	e	e	NOUN
bam-7218	1208	11	)	)	PUNCT
bam-7218	1208	12	,	,	PUNCT
bam-7218	1208	13	laura	laura	NOUN
bam-7218	1208	14	pietrangelo	pietrangelo	PROPN
bam-7218	1208	15	(	(	PUNCT
bam-7218	1208	16	f	f	X
bam-7218	1208	17	)	)	PUNCT
bam-7218	1208	18	,	,	PUNCT
bam-7218	1208	19	arianna	arianna	PROPN
bam-7218	1208	20	fusella	fusella	PROPN
bam-7218	1208	21	(	(	PUNCT
bam-7218	1208	22	f	f	PROPN
bam-7218	1208	23	)	)	PUNCT
bam-7218	1208	24	,	,	PUNCT
bam-7218	1208	25	gaia	gaia	PROPN
bam-7218	1208	26	gherardi	gherardi	PROPN
bam-7218	1208	27	(	(	PUNCT
bam-7218	1208	28	g	g	NOUN
bam-7218	1208	29	)	)	PUNCT
bam-7218	1208	30	,	,	PUNCT
bam-7218	1208	31	christian	christian	NOUN
bam-7218	1208	32	höfer	höfer	NOUN
bam-7218	1208	33	(	(	PUNCT
bam-7218	1208	34	c	c	NOUN
bam-7218	1208	35	)	)	PUNCT
bam-7218	1208	36	,	,	PUNCT
bam-7218	1209	1	stefan	stefan	PROPN
bam-7218	1209	2	löfler	löfler	PROPN
bam-7218	1209	3	s	s	PROPN
bam-7218	1209	4	(	(	PUNCT
bam-7218	1209	5	c	c	NOUN
bam-7218	1209	6	)	)	PUNCT
bam-7218	1209	7	,	,	PUNCT
bam-7218	1209	8	nejc	nejc	NOUN
bam-7218	1209	9	sarabon	sarabon	NOUN
bam-7218	1209	10	(	(	PUNCT
bam-7218	1209	11	g	g	NOUN
bam-7218	1209	12	)	)	PUNCT
bam-7218	1209	13	;	;	PUNCT
bam-7218	1209	14	jan	jan	PROPN
bam-7218	1209	15	cvecka	cvecka	NOUN
bam-7218	1209	16	(	(	PUNCT
bam-7218	1209	17	h	h	NOUN
bam-7218	1209	18	)	)	PUNCT
bam-7218	1209	19	,	,	PUNCT
bam-7218	1209	20	ugo	ugo	PROPN
bam-7218	1209	21	carraro	carraro	PROPN
bam-7218	1209	22	(	(	PUNCT
bam-7218	1209	23	i	i	NOUN
bam-7218	1209	24	)	)	PUNCT
bam-7218	1209	25	,	,	PUNCT
bam-7218	1209	26	helmut	helmut	PROPN
bam-7218	1209	27	kern	kern	PROPN
bam-7218	1209	28	(	(	PUNCT
bam-7218	1209	29	c	c	NOUN
bam-7218	1209	30	)	)	PUNCT
bam-7218	1209	31	,	,	PUNCT
bam-7218	1209	32	feliciano	feliciano	PROPN
bam-7218	1209	33	protasi	protasi	PROPN
bam-7218	1209	34	(	(	PUNCT
bam-7218	1209	35	f	f	PROPN
bam-7218	1209	36	)	)	PUNCT
bam-7218	1209	37	,	,	PUNCT
bam-7218	1209	38	antonio	antonio	PROPN
bam-7218	1209	39	musarò	musarò	NOUN
bam-7218	1209	40	(	(	PUNCT
bam-7218	1209	41	e	e	NOUN
bam-7218	1209	42	,	,	PUNCT
bam-7218	1209	43	l	l	NOUN
bam-7218	1209	44	)	)	PUNCT
bam-7218	1209	45	,	,	PUNCT
bam-7218	1209	46	rosario	rosario	PROPN
bam-7218	1209	47	rizzuto	rizzuto	PROPN
bam-7218	1209	48	(	(	PUNCT
bam-7218	1209	49	b	b	NOUN
bam-7218	1209	50	)	)	PUNCT
bam-7218	1209	51	,	,	PUNCT
bam-7218	1209	52	marco	marco	PROPN
bam-7218	1209	53	sandri	sandri	PROPN
bam-7218	1209	54	(	(	PUNCT
bam-7218	1209	55	b	b	NOUN
bam-7218	1209	56	,	,	PUNCT
bam-7218	1209	57	d	d	NOUN
bam-7218	1209	58	)	)	PUNCT
bam-7218	1209	59	(	(	PUNCT
bam-7218	1209	60	a	a	X
bam-7218	1209	61	)	)	PUNCT
bam-7218	1209	62	dept	dept	NOUN
bam-7218	1209	63	of	of	ADP
bam-7218	1209	64	biology	biology	NOUN
bam-7218	1209	65	,	,	PUNCT
bam-7218	1209	66	university	university	NOUN
bam-7218	1209	67	of	of	ADP
bam-7218	1209	68	padova	padova	PROPN
bam-7218	1209	69	;	;	PUNCT
bam-7218	1209	70	(	(	PUNCT
bam-7218	1209	71	b	b	X
bam-7218	1209	72	)	)	PUNCT
bam-7218	1209	73	dept	dept	NOUN
bam-7218	1209	74	of	of	ADP
bam-7218	1209	75	biomedical	biomedical	ADJ
bam-7218	1209	76	science	science	NOUN
bam-7218	1209	77	,	,	PUNCT
bam-7218	1209	78	university	university	PROPN
bam-7218	1209	79	of	of	ADP
bam-7218	1209	80	padova	padova	PROPN
bam-7218	1209	81	;	;	PUNCT
bam-7218	1209	82	(	(	PUNCT
bam-7218	1209	83	c	c	X
bam-7218	1209	84	)	)	PUNCT
bam-7218	1209	85	ludwig	ludwig	PROPN
bam-7218	1209	86	boltzmann	boltzmann	PROPN
bam-7218	1209	87	institute	institute	PROPN
bam-7218	1209	88	of	of	ADP
bam-7218	1209	89	electrical	electrical	ADJ
bam-7218	1209	90	stimulation	stimulation	NOUN
bam-7218	1209	91	and	and	CCONJ
bam-7218	1209	92	physical	physical	ADJ
bam-7218	1209	93	rehabilitation	rehabilitation	NOUN
bam-7218	1209	94	,	,	PUNCT
bam-7218	1209	95	vienna	vienna	PROPN
bam-7218	1209	96	,	,	PUNCT
bam-7218	1209	97	austria	austria	PROPN
bam-7218	1209	98	;	;	PUNCT
bam-7218	1209	99	(	(	PUNCT
bam-7218	1209	100	d	d	X
bam-7218	1209	101	)	)	PUNCT
bam-7218	1209	102	venetian	venetian	ADJ
bam-7218	1209	103	institute	institute	NOUN
bam-7218	1209	104	of	of	ADP
bam-7218	1209	105	molecular	molecular	ADJ
bam-7218	1209	106	medicine	medicine	NOUN
bam-7218	1209	107	,	,	PUNCT
bam-7218	1209	108	padova	padova	PROPN
bam-7218	1209	109	;	;	PUNCT
bam-7218	1209	110	(	(	PUNCT
bam-7218	1209	111	e	e	NOUN
bam-7218	1209	112	)	)	PUNCT
bam-7218	1209	113	institute	institute	PROPN
bam-7218	1209	114	pasteur	pasteur	PROPN
bam-7218	1209	115	cenci	cenci	PROPN
bam-7218	1209	116	-	-	PUNCT
bam-7218	1209	117	bolognetti	bolognetti	NOUN
bam-7218	1209	118	,	,	PUNCT
bam-7218	1209	119	dahfmo	dahfmo	NOUN
bam-7218	1209	120	-	-	PUNCT
bam-7218	1209	121	unit	unit	NOUN
bam-7218	1209	122	of	of	ADP
bam-7218	1209	123	histology	histology	NOUN
bam-7218	1209	124	and	and	CCONJ
bam-7218	1209	125	medical	medical	ADJ
bam-7218	1209	126	embryology	embryology	PROPN
bam-7218	1209	127	,	,	PUNCT
bam-7218	1209	128	sapienza	sapienza	PROPN
bam-7218	1209	129	university	university	NOUN
bam-7218	1209	130	;	;	PUNCT
bam-7218	1209	131	(	(	PUNCT
bam-7218	1209	132	f	f	X
bam-7218	1209	133	)	)	PUNCT
bam-7218	1209	134	cesi	cesi	PROPN
bam-7218	1209	135	-	-	PUNCT
bam-7218	1209	136	met	meet	VERB
bam-7218	1209	137	center	center	NOUN
bam-7218	1209	138	for	for	ADP
bam-7218	1209	139	research	research	NOUN
bam-7218	1209	140	on	on	ADP
bam-7218	1209	141	aging	age	VERB
bam-7218	1209	142	and	and	CCONJ
bam-7218	1209	143	translational	translational	ADJ
bam-7218	1209	144	medicine	medicine	NOUN
bam-7218	1209	145	&	&	CCONJ
bam-7218	1209	146	dnics	dnic	NOUN
bam-7218	1209	147	,	,	PUNCT
bam-7218	1209	148	university	university	NOUN
bam-7218	1209	149	g.	g.	PROPN
bam-7218	1209	150	d’annunzio	d’annunzio	PROPN
bam-7218	1209	151	,	,	PUNCT
bam-7218	1209	152	chieti	chieti	PROPN
bam-7218	1209	153	;	;	PUNCT
bam-7218	1209	154	(	(	PUNCT
bam-7218	1209	155	g	g	NOUN
bam-7218	1209	156	)	)	PUNCT
bam-7218	1209	157	university	university	NOUN
bam-7218	1209	158	of	of	ADP
bam-7218	1209	159	primorska	primorska	PROPN
bam-7218	1209	160	,	,	PUNCT
bam-7218	1209	161	institute	institute	NOUN
bam-7218	1209	162	for	for	ADP
bam-7218	1209	163	kinesiology	kinesiology	NOUN
bam-7218	1209	164	research	research	NOUN
bam-7218	1209	165	,	,	PUNCT
bam-7218	1209	166	koper	koper	PROPN
bam-7218	1209	167	,	,	PUNCT
bam-7218	1209	168	slovenia	slovenia	PROPN
bam-7218	1209	169	;	;	PUNCT
bam-7218	1209	170	(	(	PUNCT
bam-7218	1209	171	h	h	NOUN
bam-7218	1209	172	)	)	PUNCT
bam-7218	1209	173	faculty	faculty	NOUN
bam-7218	1209	174	of	of	ADP
bam-7218	1209	175	physical	physical	ADJ
bam-7218	1209	176	education	education	NOUN
bam-7218	1209	177	and	and	CCONJ
bam-7218	1209	178	sport	sport	NOUN
bam-7218	1209	179	,	,	PUNCT
bam-7218	1209	180	comenius	comenius	ADJ
bam-7218	1209	181	university	university	PROPN
bam-7218	1209	182	,	,	PUNCT
bam-7218	1209	183	bratislava	bratislava	PROPN
bam-7218	1209	184	,	,	PUNCT
bam-7218	1209	185	slovakia	slovakia	PROPN
bam-7218	1209	186	;	;	PUNCT
bam-7218	1209	187	(	(	PUNCT
bam-7218	1209	188	i	i	NOUN
bam-7218	1209	189	)	)	PUNCT
bam-7218	1209	190	irccs	ircc	VERB
bam-7218	1209	191	fondazione	fondazione	X
bam-7218	1209	192	ospedale	ospedale	PROPN
bam-7218	1209	193	san	san	PROPN
bam-7218	1209	194	camillo	camillo	PROPN
bam-7218	1209	195	,	,	PUNCT
bam-7218	1209	196	venezia	venezia	PROPN
bam-7218	1209	197	,	,	PUNCT
bam-7218	1209	198	italy	italy	PROPN
bam-7218	1209	199	;	;	PUNCT
bam-7218	1209	200	(	(	PUNCT
bam-7218	1209	201	l	l	NOUN
bam-7218	1209	202	)	)	PUNCT
bam-7218	1209	203	center	center	NOUN
bam-7218	1209	204	for	for	ADP
bam-7218	1209	205	life	life	NOUN
bam-7218	1209	206	nano	nano	NOUN
bam-7218	1209	207	science	science	NOUN
bam-7218	1209	208	at	at	ADP
bam-7218	1209	209	sapienza	sapienza	PROPN
bam-7218	1209	210	,	,	PUNCT
bam-7218	1209	211	istituto	istituto	X
bam-7218	1209	212	italiano	italiano	NOUN
bam-7218	1209	213	di	di	X
bam-7218	1209	214	tecnologia	tecnologia	PROPN
bam-7218	1209	215	,	,	PUNCT
bam-7218	1209	216	rome	rome	PROPN
bam-7218	1209	217	,	,	PUNCT
bam-7218	1209	218	italy	italy	PROPN
bam-7218	1209	219	.	.	PUNCT
bam-7218	1210	1	email	email	NOUN
bam-7218	1210	2	:	:	PUNCT
bam-7218	1210	3	sanzamp@unipd.it	sanzamp@unipd.it	NOUN
bam-7218	1210	4	alterations	alteration	NOUN
bam-7218	1210	5	of	of	ADP
bam-7218	1210	6	mitochondrial	mitochondrial	ADJ
bam-7218	1210	7	ca	ca	NOUN
bam-7218	1210	8	2	2	NUM
bam-7218	1210	9	+	+	NUM
bam-7218	1210	10	homeostasis	homeostasis	NOUN
bam-7218	1210	11	regulated	regulate	VERB
bam-7218	1210	12	by	by	ADP
bam-7218	1210	13	mcu	mcu	PROPN
bam-7218	1210	14	has	have	AUX
bam-7218	1210	15	been	be	AUX
bam-7218	1210	16	recently	recently	ADV
bam-7218	1210	17	shown	show	VERB
bam-7218	1210	18	to	to	PART
bam-7218	1210	19	affect	affect	VERB
bam-7218	1210	20	muscle	muscle	NOUN
bam-7218	1210	21	trophism	trophism	NOUN
bam-7218	1210	22	in	in	ADP
bam-7218	1210	23	vivo	vivo	NOUN
bam-7218	1210	24	.	.	PUNCT
bam-7218	1211	1	mice	mouse	NOUN
bam-7218	1211	2	lacking	lack	VERB
bam-7218	1211	3	mcu	mcu	PROPN
bam-7218	1211	4	exhibit	exhibit	VERB
bam-7218	1211	5	functional	functional	ADJ
bam-7218	1211	6	abnormalities	abnormality	NOUN
bam-7218	1211	7	in	in	ADP
bam-7218	1211	8	conditions	condition	NOUN
bam-7218	1211	9	that	that	PRON
bam-7218	1211	10	require	require	VERB
bam-7218	1211	11	a	a	DET
bam-7218	1211	12	rapid	rapid	ADJ
bam-7218	1211	13	increase	increase	NOUN
bam-7218	1211	14	in	in	ADP
bam-7218	1211	15	the	the	DET
bam-7218	1211	16	skeletal	skeletal	ADJ
bam-7218	1211	17	muscle	muscle	NOUN
bam-7218	1211	18	work	work	NOUN
bam-7218	1211	19	load	load	NOUN
bam-7218	1211	20	.	.	PUNCT
bam-7218	1212	1	during	during	ADP
bam-7218	1212	2	aging	age	VERB
bam-7218	1212	3	skeletal	skeletal	ADJ
bam-7218	1212	4	muscle	muscle	NOUN
bam-7218	1212	5	undergoes	undergo	VERB
bam-7218	1212	6	a	a	DET
bam-7218	1212	7	progressive	progressive	ADJ
bam-7218	1212	8	loss	loss	NOUN
bam-7218	1212	9	of	of	ADP
bam-7218	1212	10	muscle	muscle	NOUN
bam-7218	1212	11	mass	mass	NOUN
bam-7218	1212	12	,	,	PUNCT
bam-7218	1212	13	with	with	ADP
bam-7218	1212	14	decline	decline	NOUN
bam-7218	1212	15	in	in	ADP
bam-7218	1212	16	specific	specific	ADJ
bam-7218	1212	17	force	force	NOUN
bam-7218	1212	18	and	and	CCONJ
bam-7218	1212	19	functional	functional	ADJ
bam-7218	1212	20	impairment	impairment	NOUN
bam-7218	1212	21	.	.	PUNCT
bam-7218	1213	1	the	the	DET
bam-7218	1213	2	etiology	etiology	NOUN
bam-7218	1213	3	of	of	ADP
bam-7218	1213	4	this	this	DET
bam-7218	1213	5	phenomenon	phenomenon	NOUN
bam-7218	1213	6	is	be	AUX
bam-7218	1213	7	complex	complex	ADJ
bam-7218	1213	8	and	and	CCONJ
bam-7218	1213	9	involves	involve	VERB
bam-7218	1213	10	the	the	DET
bam-7218	1213	11	interplay	interplay	NOUN
bam-7218	1213	12	of	of	ADP
bam-7218	1213	13	numerous	numerous	ADJ
bam-7218	1213	14	factors	factor	NOUN
bam-7218	1213	15	whose	whose	DET
bam-7218	1213	16	underlying	underlying	ADJ
bam-7218	1213	17	mechanisms	mechanism	NOUN
bam-7218	1213	18	are	be	AUX
bam-7218	1213	19	currently	currently	ADV
bam-7218	1213	20	not	not	PART
bam-7218	1213	21	fully	fully	ADV
bam-7218	1213	22	understood	understand	VERB
bam-7218	1213	23	.	.	PUNCT
bam-7218	1214	1	physical	physical	ADJ
bam-7218	1214	2	exercise	exercise	NOUN
bam-7218	1214	3	is	be	AUX
bam-7218	1214	4	known	know	VERB
bam-7218	1214	5	to	to	PART
bam-7218	1214	6	have	have	VERB
bam-7218	1214	7	beneficial	beneficial	ADJ
bam-7218	1214	8	effects	effect	NOUN
bam-7218	1214	9	on	on	ADP
bam-7218	1214	10	muscle	muscle	NOUN
bam-7218	1214	11	trophism	trophism	NOUN
bam-7218	1214	12	and	and	CCONJ
bam-7218	1214	13	force	force	NOUN
bam-7218	1214	14	production	production	NOUN
bam-7218	1214	15	modulating	modulate	VERB
bam-7218	1214	16	signaling	signal	VERB
bam-7218	1214	17	pathways	pathway	NOUN
bam-7218	1214	18	also	also	ADV
bam-7218	1214	19	via	via	ADP
bam-7218	1214	20	intracellular	intracellular	ADJ
bam-7218	1214	21	ca	ca	NOUN
bam-7218	1214	22	2	2	NUM
bam-7218	1214	23	+	+	NUM
bam-7218	1214	24	and	and	CCONJ
bam-7218	1214	25	specific	specific	ADJ
bam-7218	1214	26	mitochondrial	mitochondrial	ADJ
bam-7218	1214	27	adaptations	adaptation	NOUN
bam-7218	1214	28	.	.	PUNCT
bam-7218	1215	1	to	to	PART
bam-7218	1215	2	understand	understand	VERB
bam-7218	1215	3	the	the	DET
bam-7218	1215	4	relevance	relevance	NOUN
bam-7218	1215	5	of	of	ADP
bam-7218	1215	6	mcudependent	mcudependent	ADJ
bam-7218	1215	7	mitochondrial	mitochondrial	ADJ
bam-7218	1215	8	ca	ca	NOUN
bam-7218	1215	9	2	2	NUM
bam-7218	1215	10	+	+	NOUN
bam-7218	1215	11	uptake	uptake	ADJ
bam-7218	1215	12	in	in	ADP
bam-7218	1215	13	aging	aging	NOUN
bam-7218	1215	14	and	and	CCONJ
bam-7218	1215	15	to	to	PART
bam-7218	1215	16	investigate	investigate	VERB
bam-7218	1215	17	the	the	DET
bam-7218	1215	18	effect	effect	NOUN
bam-7218	1215	19	of	of	ADP
bam-7218	1215	20	physical	physical	ADJ
bam-7218	1215	21	exercise	exercise	NOUN
bam-7218	1215	22	on	on	ADP
bam-7218	1215	23	mcu	mcu	PROPN
bam-7218	1215	24	expression	expression	NOUN
bam-7218	1215	25	and	and	CCONJ
bam-7218	1215	26	mitochondria	mitochondria	NOUN
bam-7218	1215	27	dynamics	dynamic	NOUN
bam-7218	1215	28	,	,	PUNCT
bam-7218	1215	29	we	we	PRON
bam-7218	1215	30	analyzed	analyze	VERB
bam-7218	1215	31	skeletal	skeletal	ADJ
bam-7218	1215	32	muscle	muscle	NOUN
bam-7218	1215	33	biopsies	biopsy	NOUN
bam-7218	1215	34	from	from	ADP
bam-7218	1215	35	70yrs	70yrs	NUM
bam-7218	1215	36	old	old	ADJ
bam-7218	1215	37	seniors	senior	NOUN
bam-7218	1215	38	,	,	PUNCT
bam-7218	1215	39	either	either	CCONJ
bam-7218	1215	40	sedentary	sedentary	ADJ
bam-7218	1215	41	,	,	PUNCT
bam-7218	1215	42	9	9	NUM
bam-7218	1215	43	weeks	week	NOUN
bam-7218	1215	44	and	and	CCONJ
bam-7218	1215	45	lifelong	lifelong	ADJ
bam-7218	1215	46	trained	train	VERB
bam-7218	1215	47	in	in	ADP
bam-7218	1215	48	comparison	comparison	NOUN
bam-7218	1215	49	to	to	ADP
bam-7218	1215	50	young	young	ADJ
bam-7218	1215	51	subjects	subject	NOUN
bam-7218	1215	52	.	.	PUNCT
bam-7218	1216	1	we	we	PRON
bam-7218	1216	2	demonstrate	demonstrate	VERB
bam-7218	1216	3	that	that	SCONJ
bam-7218	1216	4	improved	improve	VERB
bam-7218	1216	5	muscle	muscle	NOUN
bam-7218	1216	6	function	function	NOUN
bam-7218	1216	7	and	and	CCONJ
bam-7218	1216	8	structure	structure	NOUN
bam-7218	1216	9	induced	induce	VERB
bam-7218	1216	10	by	by	ADP
bam-7218	1216	11	physical	physical	ADJ
bam-7218	1216	12	exercise	exercise	NOUN
bam-7218	1216	13	are	be	AUX
bam-7218	1216	14	linked	link	VERB
bam-7218	1216	15	to	to	ADP
bam-7218	1216	16	increased	increase	VERB
bam-7218	1216	17	protein	protein	NOUN
bam-7218	1216	18	levels	level	NOUN
bam-7218	1216	19	of	of	ADP
bam-7218	1216	20	mcu	mcu	PROPN
bam-7218	1216	21	.	.	PUNCT
bam-7218	1217	1	ultrastructural	ultrastructural	ADJ
bam-7218	1217	2	analyses	analysis	NOUN
bam-7218	1217	3	by	by	ADP
bam-7218	1217	4	electron	electron	NOUN
bam-7218	1217	5	microscopy	microscopy	NOUN
bam-7218	1217	6	showed	show	VERB
bam-7218	1217	7	remodeling	remodeling	NOUN
bam-7218	1217	8	of	of	ADP
bam-7218	1217	9	mitochondrial	mitochondrial	ADJ
bam-7218	1217	10	apparatus	apparatus	NOUN
bam-7218	1217	11	in	in	ADP
bam-7218	1217	12	trained	train	VERB
bam-7218	1217	13	muscles	muscle	NOUN
bam-7218	1217	14	that	that	PRON
bam-7218	1217	15	is	be	AUX
bam-7218	1217	16	consistent	consistent	ADJ
bam-7218	1217	17	with	with	ADP
bam-7218	1217	18	an	an	DET
bam-7218	1217	19	adaptation	adaptation	NOUN
bam-7218	1217	20	to	to	ADP
bam-7218	1217	21	physical	physical	ADJ
bam-7218	1217	22	exercise	exercise	NOUN
bam-7218	1217	23	,	,	PUNCT
bam-7218	1217	24	a	a	DET
bam-7218	1217	25	response	response	NOUN
bam-7218	1217	26	likely	likely	ADV
bam-7218	1217	27	mediated	mediate	VERB
bam-7218	1217	28	by	by	ADP
bam-7218	1217	29	an	an	DET
bam-7218	1217	30	increased	increase	VERB
bam-7218	1217	31	expression	expression	NOUN
bam-7218	1217	32	of	of	ADP
bam-7218	1217	33	mitochondrial	mitochondrial	ADJ
bam-7218	1217	34	fusion	fusion	NOUN
bam-7218	1217	35	protein	protein	NOUN
bam-7218	1217	36	opa1	opa1	PROPN
bam-7218	1217	37	.	.	PUNCT
bam-7218	1218	1	altogether	altogether	ADV
bam-7218	1218	2	these	these	DET
bam-7218	1218	3	results	result	NOUN
bam-7218	1218	4	indicate	indicate	VERB
bam-7218	1218	5	that	that	SCONJ
bam-7218	1218	6	the	the	DET
bam-7218	1218	7	physiological	physiological	ADJ
bam-7218	1218	8	effects	effect	NOUN
bam-7218	1218	9	of	of	ADP
bam-7218	1218	10	exercise	exercise	NOUN
bam-7218	1218	11	on	on	ADP
bam-7218	1218	12	skeletal	skeletal	ADJ
bam-7218	1218	13	muscle	muscle	NOUN
bam-7218	1218	14	size	size	NOUN
bam-7218	1218	15	and	and	CCONJ
bam-7218	1218	16	force	force	NOUN
bam-7218	1218	17	are	be	AUX
bam-7218	1218	18	associated	associate	VERB
bam-7218	1218	19	with	with	ADP
bam-7218	1218	20	changes	change	NOUN
bam-7218	1218	21	in	in	ADP
bam-7218	1218	22	mitochondrialrelated	mitochondrialrelated	ADJ
bam-7218	1218	23	proteins	protein	NOUN
bam-7218	1218	24	involved	involve	VERB
bam-7218	1218	25	in	in	ADP
bam-7218	1218	26	ca	ca	PROPN
bam-7218	1218	27	2	2	NUM
bam-7218	1218	28	+	+	NOUN
bam-7218	1218	29	homeostasis	homeostasis	NOUN
bam-7218	1218	30	and	and	CCONJ
bam-7218	1218	31	mitochondrial	mitochondrial	ADJ
bam-7218	1218	32	shape	shape	NOUN
bam-7218	1218	33	.	.	PUNCT
bam-7218	1219	1	these	these	DET
bam-7218	1219	2	findings	finding	NOUN
bam-7218	1219	3	observed	observe	VERB
bam-7218	1219	4	for	for	ADP
bam-7218	1219	5	the	the	DET
bam-7218	1219	6	first	first	ADJ
bam-7218	1219	7	time	time	NOUN
bam-7218	1219	8	in	in	ADP
bam-7218	1219	9	aging	age	VERB
bam-7218	1219	10	human	human	ADJ
bam-7218	1219	11	skeletal	skeletal	ADJ
bam-7218	1219	12	muscle	muscle	NOUN
bam-7218	1219	13	confirm	confirm	VERB
bam-7218	1219	14	the	the	DET
bam-7218	1219	15	data	datum	NOUN
bam-7218	1219	16	obtained	obtain	VERB
bam-7218	1219	17	in	in	ADP
bam-7218	1219	18	mice	mouse	NOUN
bam-7218	1219	19	and	and	CCONJ
bam-7218	1219	20	propose	propose	VERB
bam-7218	1219	21	mcu	mcu	NOUN
bam-7218	1219	22	and	and	CCONJ
bam-7218	1219	23	mitochondria	mitochondria	ADJ
bam-7218	1219	24	related	relate	VERB
bam-7218	1219	25	proteins	protein	NOUN
bam-7218	1219	26	as	as	ADP
bam-7218	1219	27	potential	potential	ADJ
bam-7218	1219	28	pharmacological	pharmacological	ADJ
bam-7218	1219	29	targets	target	NOUN
bam-7218	1219	30	to	to	PART
bam-7218	1219	31	counteract	counteract	VERB
bam-7218	1219	32	age	age	NOUN
bam-7218	1219	33	-	-	PUNCT
bam-7218	1219	34	related	relate	VERB
bam-7218	1219	35	muscle	muscle	NOUN
bam-7218	1219	36	loss	loss	NOUN
bam-7218	1219	37	,	,	PUNCT
bam-7218	1219	38	promoting	promote	VERB
bam-7218	1219	39	healthy	healthy	ADJ
bam-7218	1219	40	aging	aging	NOUN
bam-7218	1219	41	.	.	PUNCT
bam-7218	1220	1	sandra	sandra	PROPN
bam-7218	1220	2	zampieri	zampieri	PROPN
bam-7218	1220	3	was	be	AUX
bam-7218	1220	4	supported	support	VERB
bam-7218	1220	5	by	by	ADP
bam-7218	1220	6	a&cm	a&cm	PROPN
bam-7218	1220	7	carraro	carraro	PROPN
bam-7218	1220	8	foundation	foundation	NOUN
bam-7218	1220	9	for	for	ADP
bam-7218	1220	10	translational	translational	ADJ
bam-7218	1220	11	myology	myology	NOUN
bam-7218	1220	12	,	,	PUNCT
bam-7218	1220	13	padua	padua	PROPN
bam-7218	1220	14	,	,	PUNCT
bam-7218	1220	15	italy	italy	PROPN
bam-7218	1220	16	to	to	PART
bam-7218	1220	17	attend	attend	VERB
bam-7218	1220	18	the	the	DET
bam-7218	1220	19	2017	2017	NUM
bam-7218	1220	20	iim	iim	NOUN
bam-7218	1220	21	meeting	meeting	NOUN
bam-7218	1220	22	.	.	PUNCT
bam-7218	1221	1	p.34	p.34	VERB
bam-7218	1221	2	the	the	DET
bam-7218	1221	3	role	role	NOUN
bam-7218	1221	4	of	of	ADP
bam-7218	1221	5	raptor	raptor	NOUN
bam-7218	1221	6	in	in	ADP
bam-7218	1221	7	adult	adult	NOUN
bam-7218	1221	8	skeletal	skeletal	ADJ
bam-7218	1221	9	muscle	muscle	NOUN
bam-7218	1221	10	martina	martina	PROPN
bam-7218	1221	11	baraldo	baraldo	PROPN
bam-7218	1221	12	(	(	PUNCT
bam-7218	1221	13	a	a	X
bam-7218	1221	14	)	)	PUNCT
bam-7218	1221	15	,	,	PUNCT
bam-7218	1221	16	marco	marco	PROPN
bam-7218	1221	17	sandri	sandri	PROPN
bam-7218	1221	18	(	(	PUNCT
bam-7218	1221	19	a	a	DET
bam-7218	1221	20	,	,	PUNCT
bam-7218	1221	21	b	b	NOUN
bam-7218	1221	22	)	)	PUNCT
bam-7218	1221	23	,	,	PUNCT
bam-7218	1221	24	bert	bert	PROPN
bam-7218	1221	25	blaauw	blaauw	NOUN
bam-7218	1221	26	(	(	PUNCT
bam-7218	1221	27	a	a	DET
bam-7218	1221	28	,	,	PUNCT
bam-7218	1221	29	b	b	NOUN
bam-7218	1221	30	)	)	PUNCT
bam-7218	1221	31	(	(	PUNCT
bam-7218	1221	32	a	a	X
bam-7218	1221	33	)	)	PUNCT
bam-7218	1221	34	venetian	venetian	ADJ
bam-7218	1221	35	institute	institute	NOUN
bam-7218	1221	36	of	of	ADP
bam-7218	1221	37	molecular	molecular	ADJ
bam-7218	1221	38	medicine	medicine	NOUN
bam-7218	1221	39	(	(	PUNCT
bam-7218	1221	40	vimm	vimm	PROPN
bam-7218	1221	41	)	)	PUNCT
bam-7218	1221	42	;	;	PUNCT
bam-7218	1221	43	(	(	PUNCT
bam-7218	1221	44	b	b	X
bam-7218	1221	45	)	)	PUNCT
bam-7218	1221	46	dept	dept	NOUN
bam-7218	1221	47	of	of	ADP
bam-7218	1221	48	biomedical	biomedical	ADJ
bam-7218	1221	49	sciences	sciences	PROPN
bam-7218	1221	50	,	,	PUNCT
bam-7218	1221	51	university	university	NOUN
bam-7218	1221	52	of	of	ADP
bam-7218	1221	53	padova	padova	PROPN
bam-7218	1221	54	,	,	PUNCT
bam-7218	1221	55	italy	italy	PROPN
bam-7218	1221	56	email	email	NOUN
bam-7218	1221	57	:	:	PUNCT
bam-7218	1221	58	martina.baraldo@studenti.unipd.it	martina.baraldo@studenti.unipd.it	NOUN
bam-7218	1221	59	mammalian	mammalian	ADJ
bam-7218	1221	60	target	target	NOUN
bam-7218	1221	61	of	of	ADP
bam-7218	1221	62	rapamycin	rapamycin	NOUN
bam-7218	1221	63	(	(	PUNCT
bam-7218	1221	64	mtor	mtor	PROPN
bam-7218	1221	65	)	)	PUNCT
bam-7218	1221	66	plays	play	VERB
bam-7218	1221	67	a	a	DET
bam-7218	1221	68	central	central	ADJ
bam-7218	1221	69	role	role	NOUN
bam-7218	1221	70	in	in	ADP
bam-7218	1221	71	cell	cell	NOUN
bam-7218	1221	72	growth	growth	NOUN
bam-7218	1221	73	.	.	PUNCT
bam-7218	1222	1	mtor	mtor	PROPN
bam-7218	1222	2	assembles	assemble	NOUN
bam-7218	1222	3	into	into	ADP
bam-7218	1222	4	two	two	NUM
bam-7218	1222	5	distinct	distinct	ADJ
bam-7218	1222	6	multiprotein	multiprotein	ADJ
bam-7218	1222	7	complexes	complex	NOUN
bam-7218	1222	8	,	,	PUNCT
bam-7218	1222	9	namely	namely	ADV
bam-7218	1222	10	the	the	DET
bam-7218	1222	11	rapamycinsensitive	rapamycinsensitive	ADJ
bam-7218	1222	12	complex	complex	ADJ
bam-7218	1222	13	mtorc1	mtorc1	NOUN
bam-7218	1222	14	and	and	CCONJ
bam-7218	1222	15	the	the	DET
bam-7218	1222	16	rapamycininsensitive	rapamycininsensitive	ADJ
bam-7218	1222	17	complex	complex	PROPN
bam-7218	1222	18	mtorc2	mtorc2	PROPN
bam-7218	1222	19	.	.	PUNCT
bam-7218	1223	1	one	one	NUM
bam-7218	1223	2	of	of	ADP
bam-7218	1223	3	the	the	DET
bam-7218	1223	4	key	key	ADJ
bam-7218	1223	5	members	member	NOUN
bam-7218	1223	6	of	of	ADP
bam-7218	1223	7	the	the	DET
bam-7218	1223	8	mtorc1	mtorc1	NOUN
bam-7218	1223	9	complex	complex	NOUN
bam-7218	1223	10	is	be	AUX
bam-7218	1223	11	a.	a.	NOUN
bam-7218	1223	12	150kda	150kda	NUM
bam-7218	1223	13	protein	protein	NOUN
bam-7218	1223	14	called	call	VERB
bam-7218	1223	15	raptor	raptor	NOUN
bam-7218	1223	16	,	,	PUNCT
bam-7218	1223	17	which	which	PRON
bam-7218	1223	18	has	have	AUX
bam-7218	1223	19	been	be	AUX
bam-7218	1223	20	shown	show	VERB
bam-7218	1223	21	to	to	PART
bam-7218	1223	22	be	be	AUX
bam-7218	1223	23	able	able	ADJ
bam-7218	1223	24	to	to	PART
bam-7218	1223	25	recruit	recruit	VERB
bam-7218	1223	26	mtor	mtor	NOUN
bam-7218	1223	27	substrates	substrate	NOUN
bam-7218	1223	28	s6k1	s6k1	NOUN
bam-7218	1223	29	and	and	CCONJ
bam-7218	1223	30	4ebp1	4ebp1	NUM
bam-7218	1223	31	on	on	ADP
bam-7218	1223	32	mtorc1	mtorc1	PROPN
bam-7218	1223	33	.	.	PUNCT
bam-7218	1224	1	mice	mouse	NOUN
bam-7218	1224	2	lacking	lack	VERB
bam-7218	1224	3	raptor	raptor	NOUN
bam-7218	1224	4	only	only	ADV
bam-7218	1224	5	in	in	ADP
bam-7218	1224	6	skeletal	skeletal	ADJ
bam-7218	1224	7	muscle	muscle	NOUN
bam-7218	1224	8	from	from	ADP
bam-7218	1224	9	birth	birth	NOUN
bam-7218	1224	10	show	show	VERB
bam-7218	1224	11	a	a	DET
bam-7218	1224	12	pronounced	pronounce	VERB
bam-7218	1224	13	myopathy	myopathy	ADJ
bam-7218	1224	14	leading	lead	VERB
bam-7218	1224	15	to	to	ADP
bam-7218	1224	16	a	a	DET
bam-7218	1224	17	premature	premature	ADJ
bam-7218	1224	18	death	death	NOUN
bam-7218	1224	19	.	.	PUNCT
bam-7218	1225	1	however	however	ADV
bam-7218	1225	2	,	,	PUNCT
bam-7218	1225	3	treating	treat	VERB
bam-7218	1225	4	adult	adult	NOUN
bam-7218	1225	5	mice	mouse	NOUN
bam-7218	1225	6	with	with	ADP
bam-7218	1225	7	the	the	DET
bam-7218	1225	8	specific	specific	ADJ
bam-7218	1225	9	mtorc1	mtorc1	NOUN
bam-7218	1225	10	inhibitor	inhibitor	NOUN
bam-7218	1225	11	rapamycin	rapamycin	NOUN
bam-7218	1225	12	does	do	AUX
bam-7218	1225	13	not	not	PART
bam-7218	1225	14	lead	lead	VERB
bam-7218	1225	15	to	to	ADP
bam-7218	1225	16	a	a	DET
bam-7218	1225	17	myopathic	myopathic	ADJ
bam-7218	1225	18	phenotype	phenotype	NOUN
bam-7218	1225	19	,	,	PUNCT
bam-7218	1225	20	and	and	CCONJ
bam-7218	1225	21	even	even	ADV
bam-7218	1225	22	improves	improve	VERB
bam-7218	1225	23	muscle	muscle	NOUN
bam-7218	1225	24	physiology	physiology	NOUN
bam-7218	1225	25	in	in	ADP
bam-7218	1225	26	aged	aged	ADJ
bam-7218	1225	27	mice	mouse	NOUN
bam-7218	1225	28	.	.	PUNCT
bam-7218	1226	1	here	here	ADV
bam-7218	1226	2	we	we	PRON
bam-7218	1226	3	want	want	VERB
bam-7218	1226	4	to	to	PART
bam-7218	1226	5	examine	examine	VERB
bam-7218	1226	6	the	the	DET
bam-7218	1226	7	role	role	NOUN
bam-7218	1226	8	of	of	ADP
bam-7218	1226	9	raptor	raptor	NOUN
bam-7218	1226	10	and	and	CCONJ
bam-7218	1226	11	mtorc1	mtorc1	NOUN
bam-7218	1226	12	using	use	VERB
bam-7218	1226	13	a	a	DET
bam-7218	1226	14	new	new	ADJ
bam-7218	1226	15	creerinducible	creerinducible	ADJ
bam-7218	1226	16	transgenic	transgenic	NOUN
bam-7218	1226	17	mouse	mouse	NOUN
bam-7218	1226	18	in	in	ADP
bam-7218	1226	19	which	which	PRON
bam-7218	1226	20	we	we	PRON
bam-7218	1226	21	can	can	AUX
bam-7218	1226	22	delete	delete	VERB
bam-7218	1226	23	raptor	raptor	NOUN
bam-7218	1226	24	in	in	ADP
bam-7218	1226	25	muscles	muscle	NOUN
bam-7218	1226	26	of	of	ADP
bam-7218	1226	27	adult	adult	NOUN
bam-7218	1226	28	mice	mouse	NOUN
bam-7218	1226	29	(	(	PUNCT
bam-7218	1226	30	raptor	raptor	NOUN
bam-7218	1226	31	k.o	k.o	PROPN
bam-7218	1226	32	.	.	PROPN
bam-7218	1226	33	)	)	PUNCT
bam-7218	1226	34	.	.	PUNCT
bam-7218	1227	1	activation	activation	NOUN
bam-7218	1227	2	of	of	ADP
bam-7218	1227	3	cre	cre	PROPN
bam-7218	1227	4	by	by	ADP
bam-7218	1227	5	treatment	treatment	NOUN
bam-7218	1227	6	with	with	ADP
bam-7218	1227	7	tamoxifen	tamoxifen	PROPN
bam-7218	1227	8	leads	lead	VERB
bam-7218	1227	9	to	to	ADP
bam-7218	1227	10	a	a	DET
bam-7218	1227	11	rapid	rapid	ADJ
bam-7218	1227	12	loss	loss	NOUN
bam-7218	1227	13	of	of	ADP
bam-7218	1227	14	raptor	raptor	NOUN
bam-7218	1227	15	transcript	transcript	NOUN
bam-7218	1227	16	and	and	CCONJ
bam-7218	1227	17	protein	protein	NOUN
bam-7218	1227	18	levels	level	NOUN
bam-7218	1227	19	.	.	PUNCT
bam-7218	1228	1	also	also	ADV
bam-7218	1228	2	the	the	DET
bam-7218	1228	3	phosphorylation	phosphorylation	NOUN
bam-7218	1228	4	levels	level	NOUN
bam-7218	1228	5	of	of	ADP
bam-7218	1228	6	ribosomal	ribosomal	NOUN
bam-7218	1228	7	protein	protein	NOUN
bam-7218	1228	8	s6	s6	PROPN
bam-7218	1228	9	,	,	PUNCT
bam-7218	1228	10	a	a	DET
bam-7218	1228	11	known	known	ADJ
bam-7218	1228	12	mtorc1	mtorc1	NOUN
bam-7218	1228	13	target	target	NOUN
bam-7218	1228	14	,	,	PUNCT
bam-7218	1228	15	are	be	AUX
bam-7218	1228	16	strongly	strongly	ADV
bam-7218	1228	17	reduced	reduce	VERB
bam-7218	1228	18	in	in	ADP
bam-7218	1228	19	raptor	raptor	PROPN
bam-7218	1228	20	ko	ko	PROPN
bam-7218	1228	21	mice	mice	PROPN
bam-7218	1228	22	.	.	PUNCT
bam-7218	1229	1	one	one	NUM
bam-7218	1229	2	month	month	NOUN
bam-7218	1229	3	after	after	ADP
bam-7218	1229	4	raptor	raptor	NOUN
bam-7218	1229	5	deletion	deletion	NOUN
bam-7218	1229	6	,	,	PUNCT
bam-7218	1229	7	muscle	muscle	NOUN
bam-7218	1229	8	weight	weight	NOUN
bam-7218	1229	9	and	and	CCONJ
bam-7218	1229	10	basic	basic	ADJ
bam-7218	1229	11	histology	histology	NOUN
bam-7218	1229	12	are	be	AUX
bam-7218	1229	13	unchanged	unchanged	ADJ
bam-7218	1229	14	.	.	PUNCT
bam-7218	1230	1	a	a	DET
bam-7218	1230	2	longer	long	ADJ
bam-7218	1230	3	deletion	deletion	NOUN
bam-7218	1230	4	of	of	ADP
bam-7218	1230	5	raptor	raptor	NOUN
bam-7218	1230	6	,	,	PUNCT
bam-7218	1230	7	however	however	ADV
bam-7218	1230	8	,	,	PUNCT
bam-7218	1230	9	leads	lead	VERB
bam-7218	1230	10	to	to	ADP
bam-7218	1230	11	a	a	DET
bam-7218	1230	12	myopathic	myopathic	ADJ
bam-7218	1230	13	mailto:sanzamp@unipd.it	mailto:sanzamp@unipd.it	NOUN
bam-7218	1230	14	mailto:martina.baraldo@studenti.unipd.it	mailto:martina.baraldo@studenti.unipd.it	PROPN
bam-7218	1230	15	14	14	NUM
bam-7218	1230	16	th	th	NOUN
bam-7218	1230	17	iiim	iiim	NOUN
bam-7218	1230	18	meeting	meeting	NOUN
bam-7218	1230	19	,	,	PUNCT
bam-7218	1230	20	assisi	assisi	PROPN
bam-7218	1230	21	,	,	PUNCT
bam-7218	1230	22	italy	italy	PROPN
bam-7218	1230	23	october	october	PROPN
bam-7218	1230	24	12	12	NUM
bam-7218	1230	25	-	-	SYM
bam-7218	1230	26	15	15	NUM
bam-7218	1230	27	2017	2017	NUM
bam-7218	1230	28	eur	eur	PROPN
bam-7218	1230	29	j	j	PROPN
bam-7218	1230	30	transl	transl	PROPN
bam-7218	1230	31	myol	myol	ADV
bam-7218	1230	32	27	27	NUM
bam-7218	1230	33	(	(	PUNCT
bam-7218	1230	34	4	4	NUM
bam-7218	1230	35	):	):	SYM
bam-7218	1230	36	185	185	NUM
bam-7218	1230	37	-	-	SYM
bam-7218	1230	38	224	224	NUM
bam-7218	1230	39	223	223	NUM
bam-7218	1230	40	phenotype	phenotype	NOUN
bam-7218	1230	41	with	with	ADP
bam-7218	1230	42	central	central	ADJ
bam-7218	1230	43	-	-	PUNCT
bam-7218	1230	44	core	core	NOUN
bam-7218	1230	45	structures	structure	NOUN
bam-7218	1230	46	and	and	CCONJ
bam-7218	1230	47	a	a	DET
bam-7218	1230	48	high	high	ADJ
bam-7218	1230	49	number	number	NOUN
bam-7218	1230	50	of	of	ADP
bam-7218	1230	51	small	small	ADJ
bam-7218	1230	52	and	and	CCONJ
bam-7218	1230	53	large	large	ADJ
bam-7218	1230	54	muscle	muscle	NOUN
bam-7218	1230	55	fibers	fiber	NOUN
bam-7218	1230	56	.	.	PUNCT
bam-7218	1231	1	p.35	p.35	ADJ
bam-7218	1231	2	role	role	NOUN
bam-7218	1231	3	of	of	ADP
bam-7218	1231	4	bioactive	bioactive	ADJ
bam-7218	1231	5	sphingolipids	sphingolipid	NOUN
bam-7218	1231	6	in	in	ADP
bam-7218	1231	7	skeletal	skeletal	ADJ
bam-7218	1231	8	muscle	muscle	NOUN
bam-7218	1231	9	cell	cell	NOUN
bam-7218	1231	10	degeneration	degeneration	NOUN
bam-7218	1231	11	:	:	PUNCT
bam-7218	1231	12	caenorhabditis	caenorhabditis	NOUN
bam-7218	1231	13	elegans	elegan	NOUN
bam-7218	1231	14	as	as	ADP
bam-7218	1231	15	model	model	NOUN
bam-7218	1231	16	organism	organism	PROPN
bam-7218	1231	17	elisabetta	elisabetta	PROPN
bam-7218	1231	18	meacci	meacci	PROPN
bam-7218	1231	19	,	,	PUNCT
bam-7218	1231	20	angelo	angelo	PROPN
bam-7218	1231	21	fortunato	fortunato	PROPN
bam-7218	1231	22	,	,	PUNCT
bam-7218	1231	23	francesca	francesca	PROPN
bam-7218	1231	24	matteini	matteini	PROPN
bam-7218	1231	25	,	,	PUNCT
bam-7218	1231	26	federica	federica	PROPN
bam-7218	1231	27	pierucci	pierucci	PROPN
bam-7218	1231	28	,	,	PUNCT
bam-7218	1231	29	alessia	alessia	PROPN
bam-7218	1231	30	frati	frati	PROPN
bam-7218	1231	31	,	,	PUNCT
bam-7218	1231	32	chiara	chiara	PROPN
bam-7218	1231	33	battistini	battistini	PROPN
bam-7218	1231	34	dept	dept	NOUN
bam-7218	1231	35	of	of	ADP
bam-7218	1231	36	experimental	experimental	ADJ
bam-7218	1231	37	and	and	CCONJ
bam-7218	1231	38	clinical	clinical	ADJ
bam-7218	1231	39	biomedical	biomedical	ADJ
bam-7218	1231	40	sciences	science	NOUN
bam-7218	1231	41	,	,	PUNCT
bam-7218	1231	42	molecular	molecular	ADJ
bam-7218	1231	43	biology	biology	NOUN
bam-7218	1231	44	and	and	CCONJ
bam-7218	1231	45	applied	apply	VERB
bam-7218	1231	46	biology	biology	NOUN
bam-7218	1231	47	research	research	NOUN
bam-7218	1231	48	unit	unit	NOUN
bam-7218	1231	49	university	university	PROPN
bam-7218	1231	50	of	of	ADP
bam-7218	1231	51	florence	florence	PROPN
bam-7218	1231	52	,	,	PUNCT
bam-7218	1231	53	italy	italy	PROPN
bam-7218	1231	54	.	.	PUNCT
bam-7218	1232	1	email	email	NOUN
bam-7218	1232	2	:	:	PUNCT
bam-7218	1232	3	elisabetta.meacci@unifi.it	elisabetta.meacci@unifi.it	VERB
bam-7218	1232	4	the	the	DET
bam-7218	1232	5	causes	cause	NOUN
bam-7218	1232	6	of	of	ADP
bam-7218	1232	7	skeletal	skeletal	ADJ
bam-7218	1232	8	muscle	muscle	NOUN
bam-7218	1232	9	(	(	PUNCT
bam-7218	1232	10	skm	skm	NOUN
bam-7218	1232	11	)	)	PUNCT
bam-7218	1232	12	loss	loss	NOUN
bam-7218	1232	13	in	in	ADP
bam-7218	1232	14	aging	aging	NOUN
bam-7218	1232	15	and	and	CCONJ
bam-7218	1232	16	diseases	disease	NOUN
bam-7218	1232	17	are	be	AUX
bam-7218	1232	18	complex	complex	ADJ
bam-7218	1232	19	and	and	CCONJ
bam-7218	1232	20	largely	largely	ADV
bam-7218	1232	21	unknown	unknown	ADJ
bam-7218	1232	22	.	.	PUNCT
bam-7218	1233	1	intensive	intensive	ADJ
bam-7218	1233	2	research	research	NOUN
bam-7218	1233	3	in	in	ADP
bam-7218	1233	4	simple	simple	ADJ
bam-7218	1233	5	model	model	NOUN
bam-7218	1233	6	organisms	organism	NOUN
bam-7218	1233	7	,	,	PUNCT
bam-7218	1233	8	such	such	ADJ
bam-7218	1233	9	as	as	ADP
bam-7218	1233	10	the	the	DET
bam-7218	1233	11	nematode	nematode	ADJ
bam-7218	1233	12	caenorhabditis	caenorhabditis	NOUN
bam-7218	1233	13	elegans	elegan	NOUN
bam-7218	1233	14	,	,	PUNCT
bam-7218	1233	15	which	which	PRON
bam-7218	1233	16	offers	offer	VERB
bam-7218	1233	17	the	the	DET
bam-7218	1233	18	prowess	prowess	NOUN
bam-7218	1233	19	of	of	ADP
bam-7218	1233	20	sophisticated	sophisticated	ADJ
bam-7218	1233	21	genetic	genetic	ADJ
bam-7218	1233	22	approaches	approach	NOUN
bam-7218	1233	23	and	and	CCONJ
bam-7218	1233	24	recapitulates	recapitulate	VERB
bam-7218	1233	25	aspects	aspect	NOUN
bam-7218	1233	26	of	of	ADP
bam-7218	1233	27	the	the	DET
bam-7218	1233	28	human	human	ADJ
bam-7218	1233	29	pathologies	pathology	NOUN
bam-7218	1233	30	,	,	PUNCT
bam-7218	1233	31	may	may	AUX
bam-7218	1233	32	contribute	contribute	VERB
bam-7218	1233	33	in	in	ADP
bam-7218	1233	34	understanding	understand	VERB
bam-7218	1233	35	the	the	DET
bam-7218	1233	36	molecular	molecular	ADJ
bam-7218	1233	37	mechanisms	mechanism	NOUN
bam-7218	1233	38	of	of	ADP
bam-7218	1233	39	skm	skm	NOUN
bam-7218	1233	40	cell	cell	NOUN
bam-7218	1233	41	degeneration	degeneration	NOUN
bam-7218	1233	42	.	.	PUNCT
bam-7218	1234	1	c.elegans	c.elegan	NOUN
bam-7218	1234	2	has	have	VERB
bam-7218	1234	3	distinct	distinct	ADJ
bam-7218	1234	4	striated	striated	ADJ
bam-7218	1234	5	and	and	CCONJ
bam-7218	1234	6	non	non	ADJ
bam-7218	1234	7	-	-	ADJ
bam-7218	1234	8	striated	striated	ADJ
bam-7218	1234	9	muscle	muscle	NOUN
bam-7218	1234	10	systems	system	NOUN
bam-7218	1234	11	,	,	PUNCT
bam-7218	1234	12	the	the	DET
bam-7218	1234	13	sarcomere	sarcomere	NOUN
bam-7218	1234	14	contains	contain	VERB
bam-7218	1234	15	the	the	DET
bam-7218	1234	16	same	same	ADJ
bam-7218	1234	17	or	or	CCONJ
bam-7218	1234	18	homolog	homolog	NOUN
bam-7218	1234	19	morphological	morphological	ADJ
bam-7218	1234	20	features	feature	NOUN
bam-7218	1234	21	described	describe	VERB
bam-7218	1234	22	in	in	ADP
bam-7218	1234	23	mammals	mammal	NOUN
bam-7218	1234	24	and	and	CCONJ
bam-7218	1234	25	functional	functional	ADJ
bam-7218	1234	26	age	age	NOUN
bam-7218	1234	27	-	-	PUNCT
bam-7218	1234	28	related	relate	VERB
bam-7218	1234	29	changes	change	NOUN
bam-7218	1234	30	of	of	ADP
bam-7218	1234	31	c.elegans	c.elegan	NOUN
bam-7218	1234	32	skm	skm	PROPN
bam-7218	1234	33	,	,	PUNCT
bam-7218	1234	34	including	include	VERB
bam-7218	1234	35	the	the	DET
bam-7218	1234	36	decline	decline	NOUN
bam-7218	1234	37	of	of	ADP
bam-7218	1234	38	locomotor	locomotor	PROPN
bam-7218	1234	39	behavior	behavior	NOUN
bam-7218	1234	40	,	,	PUNCT
bam-7218	1234	41	are	be	AUX
bam-7218	1234	42	similar	similar	ADJ
bam-7218	1234	43	to	to	ADP
bam-7218	1234	44	the	the	DET
bam-7218	1234	45	age	age	NOUN
bam-7218	1234	46	-	-	PUNCT
bam-7218	1234	47	related	relate	VERB
bam-7218	1234	48	or	or	CCONJ
bam-7218	1234	49	diseaseinduced	diseaseinduce	VERB
bam-7218	1234	50	modifications	modification	NOUN
bam-7218	1234	51	observed	observe	VERB
bam-7218	1234	52	in	in	ADP
bam-7218	1234	53	mammals	mammal	NOUN
bam-7218	1234	54	.	.	PUNCT
bam-7218	1235	1	sphingolipids	sphingolipid	NOUN
bam-7218	1235	2	(	(	PUNCT
bam-7218	1235	3	sls	sls	PROPN
bam-7218	1235	4	)	)	PUNCT
bam-7218	1235	5	,	,	PUNCT
bam-7218	1235	6	essential	essential	ADJ
bam-7218	1235	7	components	component	NOUN
bam-7218	1235	8	of	of	ADP
bam-7218	1235	9	eukaryotic	eukaryotic	ADJ
bam-7218	1235	10	cell	cell	NOUN
bam-7218	1235	11	membranes	membrane	NOUN
bam-7218	1235	12	and	and	CCONJ
bam-7218	1235	13	bioactive	bioactive	ADJ
bam-7218	1235	14	factors	factor	NOUN
bam-7218	1235	15	involved	involve	VERB
bam-7218	1235	16	in	in	ADP
bam-7218	1235	17	the	the	DET
bam-7218	1235	18	regulation	regulation	NOUN
bam-7218	1235	19	of	of	ADP
bam-7218	1235	20	a	a	DET
bam-7218	1235	21	variety	variety	NOUN
bam-7218	1235	22	of	of	ADP
bam-7218	1235	23	different	different	ADJ
bam-7218	1235	24	cellular	cellular	ADJ
bam-7218	1235	25	processes	process	NOUN
bam-7218	1235	26	,	,	PUNCT
bam-7218	1235	27	such	such	ADJ
bam-7218	1235	28	as	as	ADP
bam-7218	1235	29	cell	cell	NOUN
bam-7218	1235	30	growth	growth	NOUN
bam-7218	1235	31	and	and	CCONJ
bam-7218	1235	32	differentiation	differentiation	NOUN
bam-7218	1235	33	,	,	PUNCT
bam-7218	1235	34	are	be	AUX
bam-7218	1235	35	also	also	ADV
bam-7218	1235	36	emerging	emerge	VERB
bam-7218	1235	37	as	as	ADP
bam-7218	1235	38	key	key	ADJ
bam-7218	1235	39	regulators	regulator	NOUN
bam-7218	1235	40	of	of	ADP
bam-7218	1235	41	skm	skm	NOUN
bam-7218	1235	42	cell	cell	NOUN
bam-7218	1235	43	biology	biology	NOUN
bam-7218	1235	44	.	.	PUNCT
bam-7218	1236	1	in	in	ADP
bam-7218	1236	2	particular	particular	ADJ
bam-7218	1236	3	,	,	PUNCT
bam-7218	1236	4	sphingosine	sphingosine	NOUN
bam-7218	1236	5	1	1	NUM
bam-7218	1236	6	-	-	PUNCT
bam-7218	1236	7	phosphate	phosphate	NOUN
bam-7218	1236	8	attenuates	attenuate	VERB
bam-7218	1236	9	the	the	DET
bam-7218	1236	10	muscle	muscle	NOUN
bam-7218	1236	11	damage	damage	NOUN
bam-7218	1236	12	,	,	PUNCT
bam-7218	1236	13	protect	protect	VERB
bam-7218	1236	14	the	the	DET
bam-7218	1236	15	muscle	muscle	NOUN
bam-7218	1236	16	fiber	fiber	NOUN
bam-7218	1236	17	from	from	ADP
bam-7218	1236	18	apoptosis	apoptosis	NOUN
bam-7218	1236	19	and	and	CCONJ
bam-7218	1236	20	preserve	preserve	VERB
bam-7218	1236	21	satellite	satellite	NOUN
bam-7218	1236	22	cell	cell	NOUN
bam-7218	1236	23	viability	viability	NOUN
bam-7218	1236	24	and	and	CCONJ
bam-7218	1236	25	renewal	renewal	NOUN
bam-7218	1236	26	(	(	PUNCT
bam-7218	1236	27	sassoli	sassoli	NOUN
bam-7218	1236	28	et	et	PROPN
bam-7218	1236	29	al	al	PROPN
bam-7218	1236	30	.	.	PROPN
bam-7218	1236	31	,	,	PUNCT
bam-7218	1236	32	2011	2011	NUM
bam-7218	1236	33	;	;	PUNCT
bam-7218	1236	34	meacci	meacci	PROPN
bam-7218	1236	35	et	et	PROPN
bam-7218	1236	36	al	al	PROPN
bam-7218	1236	37	.	.	PROPN
bam-7218	1236	38	,	,	PUNCT
bam-7218	1236	39	2008	2008	NUM
bam-7218	1236	40	)	)	PUNCT
bam-7218	1236	41	.	.	PUNCT
bam-7218	1237	1	since	since	SCONJ
bam-7218	1237	2	the	the	DET
bam-7218	1237	3	principal	principal	ADJ
bam-7218	1237	4	components	component	NOUN
bam-7218	1237	5	of	of	ADP
bam-7218	1237	6	sl	sl	INTJ
bam-7218	1237	7	biochemical	biochemical	ADJ
bam-7218	1237	8	pathways	pathway	NOUN
bam-7218	1237	9	are	be	AUX
bam-7218	1237	10	also	also	ADV
bam-7218	1237	11	described	describe	VERB
bam-7218	1237	12	in	in	ADP
bam-7218	1237	13	the	the	DET
bam-7218	1237	14	nematode	nematode	NOUN
bam-7218	1237	15	,	,	PUNCT
bam-7218	1237	16	here	here	ADV
bam-7218	1237	17	,	,	PUNCT
bam-7218	1237	18	we	we	PRON
bam-7218	1237	19	provide	provide	VERB
bam-7218	1237	20	evidence	evidence	NOUN
bam-7218	1237	21	of	of	ADP
bam-7218	1237	22	s1p	s1p	NOUN
bam-7218	1237	23	signaling	signal	VERB
bam-7218	1237	24	involvement	involvement	NOUN
bam-7218	1237	25	in	in	ADP
bam-7218	1237	26	the	the	DET
bam-7218	1237	27	maintaining	maintaining	NOUN
bam-7218	1237	28	of	of	ADP
bam-7218	1237	29	skm	skm	NOUN
bam-7218	1237	30	phenotype	phenotype	NOUN
bam-7218	1237	31	.	.	PUNCT
bam-7218	1238	1	grants	grant	NOUN
bam-7218	1238	2	from	from	ADP
bam-7218	1238	3	miur	miur	NOUN
bam-7218	1238	4	and	and	CCONJ
bam-7218	1238	5	fondazione	fondazione	NOUN
bam-7218	1238	6	cassa	cassa	PROPN
bam-7218	1238	7	di	di	PROPN
bam-7218	1238	8	risparmio	risparmio	PROPN
bam-7218	1238	9	di	di	PROPN
bam-7218	1238	10	pistoia	pistoia	PROPN
bam-7218	1238	11	e	e	PROPN
bam-7218	1238	12	pescia	pescia	PROPN
bam-7218	1238	13	.	.	PUNCT
bam-7218	1239	1	references	reference	NOUN
bam-7218	1239	2	.	.	PUNCT
bam-7218	1240	1	sassoli	sassoli	NOUN
bam-7218	1240	2	et	et	PROPN
bam-7218	1240	3	al	al	PROPN
bam-7218	1240	4	.	.	PUNCT
bam-7218	1241	1	j	j	PROPN
bam-7218	1241	2	cell	cell	NOUN
bam-7218	1241	3	mol	mol	ADP
bam-7218	1241	4	medicine	medicine	NOUN
bam-7218	1241	5	2011;1	2011;1	NOUN
bam-7218	1241	6	:	:	PUNCT
bam-7218	1241	7	24982511	24982511	NUM
bam-7218	1241	8	.	.	PUNCT
bam-7218	1242	1	meacci	meacci	PROPN
bam-7218	1242	2	et	et	PROPN
bam-7218	1242	3	al	al	PROPN
bam-7218	1242	4	.	.	PROPN
bam-7218	1242	5	,	,	PUNCT
bam-7218	1242	6	methods	method	NOUN
bam-7218	1242	7	in	in	ADP
bam-7218	1242	8	molecular	molecular	ADJ
bam-7218	1242	9	biology	biology	NOUN
bam-7218	1242	10	2012	2012	NUM
bam-7218	1242	11	:	:	PUNCT
bam-7218	1242	12	1:155	1:155	PROPN
bam-7218	1242	13	-	-	SYM
bam-7218	1242	14	65	65	NUM
bam-7218	1242	15	.	.	PUNCT
bam-7218	1242	16	index	index	NOUN
bam-7218	1242	17	of	of	ADP
bam-7218	1242	18	authors	author	NOUN
bam-7218	1242	19	acquasaliente	acquasaliente	ADJ
bam-7218	1242	20	l	l	NOUN
bam-7218	1242	21	,	,	PUNCT
bam-7218	1242	22	203	203	NUM
bam-7218	1242	23	adamo	adamo	PROPN
bam-7218	1242	24	s	s	PROPN
bam-7218	1242	25	,	,	PUNCT
bam-7218	1242	26	194,199	194,199	NUM
bam-7218	1242	27	agosti	agosti	NOUN
bam-7218	1242	28	e	e	NOUN
bam-7218	1242	29	,	,	PUNCT
bam-7218	1242	30	208,219	208,219	NUM
bam-7218	1242	31	angelino	angelino	NOUN
bam-7218	1242	32	e	e	NOUN
bam-7218	1242	33	,	,	PUNCT
bam-7218	1242	34	208,219	208,219	NUM
bam-7218	1242	35	annibalini	annibalini	NOUN
bam-7218	1242	36	g	g	PROPN
bam-7218	1242	37	,	,	PUNCT
bam-7218	1242	38	209,212	209,212	NUM
bam-7218	1242	39	,	,	PUNCT
bam-7218	1242	40	213,217	213,217	NUM
bam-7218	1242	41	antonini	antonini	PROPN
bam-7218	1242	42	s	s	SYM
bam-7218	1242	43	,	,	PUNCT
bam-7218	1242	44	192,200,218	192,200,218	NUM
bam-7218	1242	45	arato	arato	NOUN
bam-7218	1242	46	i	i	PRON
bam-7218	1242	47	,	,	PUNCT
bam-7218	1242	48	220	220	NUM
bam-7218	1242	49	arjomand	arjomand	NOUN
bam-7218	1242	50	j	j	PROPN
bam-7218	1242	51	,	,	PUNCT
bam-7218	1242	52	200,209	200,209	NUM
bam-7218	1242	53	ascenzi	ascenzi	NOUN
bam-7218	1242	54	f	f	PROPN
bam-7218	1242	55	,	,	PUNCT
bam-7218	1242	56	209	209	NUM
bam-7218	1242	57	asperti	asperti	PROPN
bam-7218	1242	58	m	m	PROPN
bam-7218	1242	59	,	,	PUNCT
bam-7218	1242	60	205	205	NUM
bam-7218	1242	61	atari	atari	NOUN
bam-7218	1242	62	m	m	SYM
bam-7218	1242	63	,	,	PUNCT
bam-7218	1242	64	204	204	NUM
bam-7218	1242	65	ballarò	ballarò	NOUN
bam-7218	1242	66	r	r	NOUN
bam-7218	1242	67	,	,	PUNCT
bam-7218	1242	68	210	210	NUM
bam-7218	1242	69	baraldo	baraldo	NOUN
bam-7218	1242	70	m	m	NOUN
bam-7218	1242	71	,	,	PUNCT
bam-7218	1242	72	222	222	NUM
bam-7218	1242	73	barberi	barberi	NOUN
bam-7218	1242	74	l	l	PROPN
bam-7218	1242	75	,	,	PUNCT
bam-7218	1242	76	209,222	209,222	NUM
bam-7218	1242	77	barbieri	barbieri	PROPN
bam-7218	1242	78	e	e	PROPN
bam-7218	1242	79	,	,	PUNCT
bam-7218	1242	80	209,213,220	209,213,220	NUM
bam-7218	1242	81	barton	barton	NOUN
bam-7218	1242	82	e	e	NOUN
bam-7218	1242	83	,	,	PUNCT
bam-7218	1242	84	197	197	NUM
bam-7218	1242	85	bastoni	bastoni	NOUN
bam-7218	1242	86	m	m	PROPN
bam-7218	1242	87	,	,	PUNCT
bam-7218	1242	88	218	218	NUM
bam-7218	1242	89	battistelli	battistelli	NOUN
bam-7218	1242	90	m	m	PROPN
bam-7218	1242	91	,	,	PUNCT
bam-7218	1242	92	211	211	NUM
bam-7218	1242	93	battistini	battistini	ADJ
bam-7218	1242	94	c	c	NOUN
bam-7218	1242	95	,	,	PUNCT
bam-7218	1242	96	223	223	NUM
bam-7218	1242	97	belicchi	belicchi	PROPN
bam-7218	1242	98	m	m	PROPN
bam-7218	1242	99	,	,	PUNCT
bam-7218	1242	100	205	205	NUM
bam-7218	1242	101	bella	bella	NOUN
bam-7218	1242	102	p	p	NOUN
bam-7218	1242	103	,	,	PUNCT
bam-7218	1242	104	205	205	NUM
bam-7218	1242	105	bellazzi	bellazzi	NOUN
bam-7218	1242	106	r	r	NOUN
bam-7218	1242	107	,	,	PUNCT
bam-7218	1242	108	202	202	NUM
bam-7218	1242	109	belotti	belotti	ADJ
bam-7218	1242	110	g	g	NOUN
bam-7218	1242	111	,	,	PUNCT
bam-7218	1242	112	202	202	NUM
bam-7218	1242	113	beltrà	beltrà	NOUN
bam-7218	1242	114	m	m	PROPN
bam-7218	1242	115	,	,	PUNCT
bam-7218	1242	116	210	210	NUM
bam-7218	1242	117	beltrame	beltrame	NOUN
bam-7218	1242	118	l	l	NOUN
bam-7218	1242	119	,	,	PUNCT
bam-7218	1242	120	206	206	NUM
bam-7218	1242	121	bendotti	bendotti	NOUN
bam-7218	1242	122	c	c	NOUN
bam-7218	1242	123	,	,	PUNCT
bam-7218	1242	124	206	206	NUM
bam-7218	1242	125	benedetti	benedetti	PROPN
bam-7218	1242	126	l	l	PROPN
bam-7218	1242	127	,	,	PUNCT
bam-7218	1242	128	202	202	NUM
bam-7218	1242	129	benelli	benelli	PROPN
bam-7218	1242	130	p	p	X
bam-7218	1242	131	,	,	PUNCT
bam-7218	1242	132	213	213	NUM
bam-7218	1242	133	benfenati	benfenati	NOUN
bam-7218	1242	134	f	f	NOUN
bam-7218	1242	135	,	,	PUNCT
bam-7218	1242	136	194	194	NUM
bam-7218	1242	137	bernadzki	bernadzki	NOUN
bam-7218	1242	138	km	km	PROPN
bam-7218	1242	139	,	,	PUNCT
bam-7218	1242	140	189	189	NUM
bam-7218	1242	141	bertin	bertin	PROPN
bam-7218	1242	142	m	m	PROPN
bam-7218	1242	143	,	,	PUNCT
bam-7218	1242	144	194	194	NUM
bam-7218	1242	145	bertini	bertini	PROPN
bam-7218	1242	146	e	e	PROPN
bam-7218	1242	147	,	,	PUNCT
bam-7218	1242	148	219	219	NUM
bam-7218	1242	149	bertrand	bertrand	PROPN
bam-7218	1242	150	a	a	PRON
bam-7218	1242	151	,	,	PUNCT
bam-7218	1242	152	202	202	NUM
bam-7218	1242	153	bianchi	bianchi	NOUN
bam-7218	1242	154	m	m	PROPN
bam-7218	1242	155	,	,	PUNCT
bam-7218	1242	156	194	194	NUM
bam-7218	1242	157	bianconi	bianconi	NOUN
bam-7218	1242	158	v	v	NOUN
bam-7218	1242	159	,	,	PUNCT
bam-7218	1242	160	198	198	NUM
bam-7218	1242	161	biferali	biferali	PROPN
bam-7218	1242	162	b	b	PROPN
bam-7218	1242	163	,	,	PUNCT
bam-7218	1242	164	198	198	NUM
bam-7218	1242	165	bindels	bindel	NOUN
bam-7218	1242	166	l	l	NOUN
bam-7218	1242	167	,	,	PUNCT
bam-7218	1242	168	222	222	NUM
bam-7218	1242	169	blaauw	blaauw	NOUN
bam-7218	1242	170	b	b	NOUN
bam-7218	1242	171	,	,	PUNCT
bam-7218	1242	172	196,201,213,222	196,201,213,222	NUM
bam-7218	1242	173	blegniski	blegniski	PROPN
bam-7218	1242	174	fp	fp	NOUN
bam-7218	1242	175	,	,	PUNCT
bam-7218	1242	176	210	210	NUM
bam-7218	1242	177	blum	blum	NOUN
bam-7218	1242	178	h	h	NOUN
bam-7218	1242	179	,	,	PUNCT
bam-7218	1242	180	198	198	NUM
bam-7218	1242	181	bonazza	bonazza	NOUN
bam-7218	1242	182	f	f	PROPN
bam-7218	1242	183	,	,	PUNCT
bam-7218	1242	184	211	211	NUM
bam-7218	1242	185	boncompagni	boncompagni	NOUN
bam-7218	1242	186	s	s	PART
bam-7218	1242	187	,	,	PUNCT
bam-7218	1242	188	192,193,210	192,193,210	NUM
bam-7218	1242	189	bonetto	bonetto	NOUN
bam-7218	1242	190	v	v	NOUN
bam-7218	1242	191	,	,	PUNCT
bam-7218	1242	192	206	206	NUM
bam-7218	1242	193	bonfanti	bonfanti	NOUN
bam-7218	1242	194	c	c	NOUN
bam-7218	1242	195	,	,	PUNCT
bam-7218	1242	196	192,192,200,218	192,192,200,218	NUM
bam-7218	1242	197	bonne	bonne	PROPN
bam-7218	1242	198	g	g	PROPN
bam-7218	1242	199	,	,	PUNCT
bam-7218	1242	200	202	202	NUM
bam-7218	1242	201	bottinelli	bottinelli	NOUN
bam-7218	1242	202	r	r	PROPN
bam-7218	1242	203	,	,	PUNCT
bam-7218	1242	204	211	211	NUM
bam-7218	1242	205	bowers	bower	NOUN
bam-7218	1242	206	c	c	NOUN
bam-7218	1242	207	,	,	PUNCT
bam-7218	1242	208	191	191	NUM
bam-7218	1242	209	bozzoni	bozzoni	NOUN
bam-7218	1242	210	i	i	NOUN
bam-7218	1242	211	,	,	PUNCT
bam-7218	1242	212	220	220	NUM
bam-7218	1242	213	brand	brand	NOUN
bam-7218	1242	214	t	t	PROPN
bam-7218	1242	215	,	,	PUNCT
bam-7218	1242	216	198	198	NUM
bam-7218	1242	217	brandi	brandi	NOUN
bam-7218	1242	218	g	g	PROPN
bam-7218	1242	219	,	,	PUNCT
bam-7218	1242	220	209	209	NUM
bam-7218	1242	221	brauer	brauer	PROPN
bam-7218	1242	222	e	e	PROPN
bam-7218	1242	223	,	,	PUNCT
bam-7218	1242	224	217	217	NUM
bam-7218	1242	225	breuls	breul	NOUN
bam-7218	1242	226	n	n	CCONJ
bam-7218	1242	227	,	,	PUNCT
bam-7218	1242	228	203	203	NUM
bam-7218	1242	229	brocca	brocca	NOUN
bam-7218	1242	230	l	l	NOUN
bam-7218	1242	231	,	,	PUNCT
bam-7218	1242	232	211	211	NUM
bam-7218	1242	233	brucoli	brucoli	NOUN
bam-7218	1242	234	m	m	PROPN
bam-7218	1242	235	,	,	PUNCT
bam-7218	1242	236	190	190	NUM
bam-7218	1242	237	buchkremer	buchkremer	NOUN
bam-7218	1242	238	s	s	PROPN
bam-7218	1242	239	,	,	PUNCT
bam-7218	1242	240	217	217	NUM
bam-7218	1242	241	bultynck	bultynck	NOUN
bam-7218	1242	242	g	g	NOUN
bam-7218	1242	243	,	,	PUNCT
bam-7218	1242	244	196	196	NUM
bam-7218	1242	245	burattini	burattini	PROPN
bam-7218	1242	246	s	s	PROPN
bam-7218	1242	247	,	,	PUNCT
bam-7218	1242	248	211	211	NUM
bam-7218	1242	249	burini	burini	NOUN
bam-7218	1242	250	d	d	NOUN
bam-7218	1242	251	,	,	PUNCT
bam-7218	1242	252	211	211	NUM
bam-7218	1242	253	bursac	bursac	NOUN
bam-7218	1242	254	n	n	CCONJ
bam-7218	1242	255	,	,	PUNCT
bam-7218	1242	256	209	209	NUM
bam-7218	1242	257	butera	butera	NOUN
bam-7218	1242	258	g	g	PROPN
bam-7218	1242	259	,	,	PUNCT
bam-7218	1242	260	203	203	NUM
bam-7218	1242	261	cairns	cairn	NOUN
bam-7218	1242	262	g	g	NOUN
bam-7218	1242	263	,	,	PUNCT
bam-7218	1242	264	191	191	NUM
bam-7218	1242	265	calafiore	calafiore	NOUN
bam-7218	1242	266	r	r	NOUN
bam-7218	1242	267	,	,	PUNCT
bam-7218	1242	268	220	220	NUM
bam-7218	1242	269	calcabrini	calcabrini	NOUN
bam-7218	1242	270	c	c	NOUN
bam-7218	1242	271	,	,	PUNCT
bam-7218	1242	272	220	220	NUM
bam-7218	1242	273	calvitti	calvitti	NOUN
bam-7218	1242	274	m	m	NOUN
bam-7218	1242	275	,	,	PUNCT
bam-7218	1242	276	220	220	NUM
bam-7218	1242	277	camerino	camerino	NOUN
bam-7218	1242	278	gm	gm	PROPN
bam-7218	1242	279	,	,	PUNCT
bam-7218	1242	280	193	193	NUM
bam-7218	1242	281	camero	camero	PROPN
bam-7218	1242	282	s	s	PROPN
bam-7218	1242	283	,	,	PUNCT
bam-7218	1242	284	220	220	NUM
bam-7218	1242	285	campbell	campbell	PROPN
bam-7218	1242	286	k	k	PROPN
bam-7218	1242	287	,	,	PUNCT
bam-7218	1242	288	213	213	NUM
bam-7218	1242	289	cannata	cannata	NOUN
bam-7218	1242	290	s	s	NOUN
bam-7218	1242	291	,	,	PUNCT
bam-7218	1242	292	195	195	NUM
bam-7218	1242	293	cappella	cappella	NOUN
bam-7218	1242	294	m	m	PROPN
bam-7218	1242	295	,	,	PUNCT
bam-7218	1242	296	199	199	NUM
bam-7218	1242	297	caprini	caprini	NOUN
bam-7218	1242	298	g	g	NOUN
bam-7218	1242	299	,	,	PUNCT
bam-7218	1242	300	215	215	NUM
bam-7218	1242	301	cardani	cardani	NOUN
bam-7218	1242	302	r	r	NOUN
bam-7218	1242	303	,	,	PUNCT
bam-7218	1242	304	199	199	NUM
bam-7218	1242	305	cardinali	cardinali	ADJ
bam-7218	1242	306	b	b	PROPN
bam-7218	1242	307	,	,	PUNCT
bam-7218	1242	308	199	199	NUM
bam-7218	1242	309	carotti	carotti	NOUN
bam-7218	1242	310	m	m	PROPN
bam-7218	1242	311	,	,	PUNCT
bam-7218	1242	312	200,203	200,203	NUM
bam-7218	1242	313	carr	carr	PROPN
bam-7218	1242	314	s	s	PROPN
bam-7218	1242	315	,	,	PUNCT
bam-7218	1242	316	198,217	198,217	NUM
bam-7218	1242	317	carraro	carraro	NOUN
bam-7218	1242	318	u	u	NOUN
bam-7218	1242	319	,	,	PUNCT
bam-7218	1242	320	222	222	NUM
bam-7218	1242	321	caruso	caruso	NOUN
bam-7218	1242	322	e	e	PROPN
bam-7218	1242	323	,	,	PUNCT
bam-7218	1242	324	200	200	NUM
bam-7218	1242	325	castagnoli	castagnoli	NOUN
bam-7218	1242	326	l	l	NOUN
bam-7218	1242	327	,	,	PUNCT
bam-7218	1242	328	201,216	201,216	NUM
bam-7218	1242	329	catteruccia	catteruccia	NOUN
bam-7218	1242	330	m	m	PROPN
bam-7218	1242	331	,	,	PUNCT
bam-7218	1242	332	219	219	NUM
bam-7218	1242	333	ceccarelli	ceccarelli	ADV
bam-7218	1242	334	g	g	NOUN
bam-7218	1242	335	,	,	PUNCT
bam-7218	1242	336	202	202	NUM
bam-7218	1242	337	ceccaroli	ceccaroli	VERB
bam-7218	1242	338	p	p	NOUN
bam-7218	1242	339	,	,	PUNCT
bam-7218	1242	340	212,213,217	212,213,217	NUM
bam-7218	1242	341	cecchini	cecchini	NOUN
bam-7218	1242	342	r	r	NOUN
bam-7218	1242	343	,	,	PUNCT
bam-7218	1242	344	210	210	NUM
bam-7218	1242	345	cesareni	cesareni	NOUN
bam-7218	1242	346	g	g	NOUN
bam-7218	1242	347	,	,	PUNCT
bam-7218	1242	348	195,201,216	195,201,216	NUM
bam-7218	1242	349	checchetto	checchetto	NOUN
bam-7218	1242	350	v	v	NOUN
bam-7218	1242	351	,	,	PUNCT
bam-7218	1242	352	203	203	NUM
bam-7218	1242	353	chemello	chemello	NOUN
bam-7218	1242	354	f	f	X
bam-7218	1242	355	,	,	PUNCT
bam-7218	1242	356	201	201	NUM
bam-7218	1242	357	chiappalupi	chiappalupi	NOUN
bam-7218	1242	358	s	s	NOUN
bam-7218	1242	359	,	,	PUNCT
bam-7218	1242	360	212,220	212,220	NUM
bam-7218	1242	361	cipriani	cipriani	PROPN
bam-7218	1242	362	s	s	PROPN
bam-7218	1242	363	,	,	PUNCT
bam-7218	1242	364	204	204	NUM
bam-7218	1242	365	clementi	clementi	PROPN
bam-7218	1242	366	e	e	PROPN
bam-7218	1242	367	,	,	PUNCT
bam-7218	1242	368	195	195	NUM
bam-7218	1242	369	clerici	clerici	NOUN
bam-7218	1242	370	s	s	NOUN
bam-7218	1242	371	,	,	PUNCT
bam-7218	1242	372	208,219	208,219	NUM
bam-7218	1242	373	codenotti	codenotti	NOUN
bam-7218	1242	374	s	s	NOUN
bam-7218	1242	375	,	,	PUNCT
bam-7218	1242	376	205,211,218	205,211,218	NUM
bam-7218	1242	377	coirault	coirault	VERB
bam-7218	1242	378	c	c	NOUN
bam-7218	1242	379	,	,	PUNCT
bam-7218	1242	380	202	202	NUM
bam-7218	1242	381	conijn	conijn	NOUN
bam-7218	1242	382	s	s	NOUN
bam-7218	1242	383	,	,	PUNCT
bam-7218	1242	384	213	213	NUM
bam-7218	1242	385	consalvi	consalvi	NOUN
bam-7218	1242	386	s	s	NOUN
bam-7218	1242	387	,	,	PUNCT
bam-7218	1242	388	194,221	194,221	NUM
bam-7218	1242	389	contarelli	contarelli	NOUN
bam-7218	1242	390	s	s	PROPN
bam-7218	1242	391	,	,	PUNCT
bam-7218	1242	392	209,213	209,213	NUM
bam-7218	1242	393	conte	conte	NOUN
bam-7218	1242	394	e	e	NOUN
bam-7218	1242	395	,	,	PUNCT
bam-7218	1242	396	193	193	NUM
bam-7218	1242	397	cordts	cordts	ADJ
bam-7218	1242	398	i	i	PRON
bam-7218	1242	399	,	,	PUNCT
bam-7218	1242	400	191	191	NUM
bam-7218	1242	401	costamagna	costamagna	NOUN
bam-7218	1242	402	d	d	PROPN
bam-7218	1242	403	,	,	PUNCT
bam-7218	1242	404	203,204	203,204	NUM
bam-7218	1242	405	,	,	PUNCT
bam-7218	1242	406	207	207	NUM
bam-7218	1242	407	,	,	PUNCT
bam-7218	1242	408	207,214	207,214	NUM
bam-7218	1242	409	costelli	costelli	ADV
bam-7218	1242	410	p	p	X
bam-7218	1242	411	,	,	PUNCT
bam-7218	1242	412	210	210	NUM
bam-7218	1242	413	curzi	curzi	NOUN
bam-7218	1242	414	d	d	PROPN
bam-7218	1242	415	,	,	PUNCT
bam-7218	1242	416	221	221	NUM
bam-7218	1242	417	cusella	cusella	NOUN
bam-7218	1242	418	de	de	X
bam-7218	1242	419	angelis	angelis	PROPN
bam-7218	1242	420	mg	mg	PROPN
bam-7218	1242	421	,	,	PUNCT
bam-7218	1242	422	202	202	NUM
bam-7218	1242	423	cvecka	cvecka	PROPN
bam-7218	1242	424	j	j	PROPN
bam-7218	1242	425	,	,	PUNCT
bam-7218	1242	426	222	222	NUM
bam-7218	1242	427	d’amico	d’amico	NOUN
bam-7218	1242	428	a	a	DET
bam-7218	1242	429	,	,	PUNCT
bam-7218	1242	430	219	219	NUM
bam-7218	1242	431	dattilo	dattilo	ADV
bam-7218	1243	1	d	d	NOUN
bam-7218	1243	2	,	,	PUNCT
bam-7218	1243	3	220	220	NUM
bam-7218	1243	4	de	de	X
bam-7218	1243	5	bardi	bardi	PROPN
bam-7218	1243	6	m	m	PROPN
bam-7218	1243	7	,	,	PUNCT
bam-7218	1243	8	194	194	NUM
bam-7218	1243	9	de	de	PROPN
bam-7218	1243	10	bellis	bellis	PROPN
bam-7218	1243	11	m	m	PROPN
bam-7218	1243	12	,	,	PUNCT
bam-7218	1243	13	193	193	NUM
bam-7218	1243	14	de	de	X
bam-7218	1243	15	coppi	coppi	NOUN
bam-7218	1243	16	p	p	NOUN
bam-7218	1243	17	,	,	PUNCT
bam-7218	1243	18	196	196	NUM
bam-7218	1243	19	de	de	PROPN
bam-7218	1243	20	feudis	feudis	PROPN
bam-7218	1243	21	m	m	PROPN
bam-7218	1243	22	,	,	PUNCT
bam-7218	1243	23	208,219	208,219	NUM
bam-7218	1243	24	de	de	X
bam-7218	1243	25	filippis	filippis	PROPN
bam-7218	1243	26	v	v	ADP
bam-7218	1243	27	,	,	PUNCT
bam-7218	1243	28	203	203	NUM
bam-7218	1243	29	de	de	X
bam-7218	1243	30	majo	majo	PROPN
bam-7218	1243	31	f	f	PROPN
bam-7218	1243	32	,	,	PUNCT
bam-7218	1243	33	197	197	NUM
bam-7218	1243	34	de	de	X
bam-7218	1243	35	palma	palma	PROPN
bam-7218	1243	36	c	c	NOUN
bam-7218	1243	37	,	,	PUNCT
bam-7218	1243	38	190,195	190,195	NUM
bam-7218	1243	39	de	de	X
bam-7218	1243	40	santi	santi	PROPN
bam-7218	1243	41	m	m	PROPN
bam-7218	1243	42	,	,	PUNCT
bam-7218	1243	43	209	209	NUM
bam-7218	1243	44	de	de	X
bam-7218	1243	45	santis	santis	PROPN
bam-7218	1243	46	f	f	PROPN
bam-7218	1243	47	,	,	PUNCT
bam-7218	1243	48	205	205	NUM
bam-7218	1243	49	de	de	PROPN
bam-7218	1243	50	santis	santis	PROPN
bam-7218	1243	51	j	j	PROPN
bam-7218	1243	52	,	,	PUNCT
bam-7218	1243	53	215	215	NUM
bam-7218	1243	54	de	de	X
bam-7218	1243	55	stefani	stefani	PROPN
bam-7218	1243	56	d	d	PROPN
bam-7218	1243	57	,	,	PUNCT
bam-7218	1243	58	190	190	NUM
bam-7218	1243	59	de	de	PROPN
bam-7218	1243	60	winter	winter	PROPN
bam-7218	1243	61	j	j	PROPN
bam-7218	1243	62	,	,	PUNCT
bam-7218	1243	63	213	213	NUM
bam-7218	1243	64	di	di	X
bam-7218	1243	65	filippo	filippo	PROPN
bam-7218	1243	66	es	es	PROPN
bam-7218	1243	67	,	,	PUNCT
bam-7218	1243	68	207,214,220	207,214,220	NUM
bam-7218	1243	69	di	di	NOUN
bam-7218	1243	70	renzo	renzo	PROPN
bam-7218	1243	71	i	i	PRON
bam-7218	1243	72	,	,	PUNCT
bam-7218	1243	73	195	195	NUM
bam-7218	1243	74	di	di	NOUN
bam-7218	1243	75	timoteo	timoteo	NOUN
bam-7218	1243	76	g	g	NOUN
bam-7218	1243	77	,	,	PUNCT
bam-7218	1243	78	220	220	NUM
bam-7218	1243	79	dobrowolny	dobrowolny	NOUN
bam-7218	1243	80	g	g	NOUN
bam-7218	1243	81	,	,	PUNCT
bam-7218	1243	82	193	193	NUM
bam-7218	1243	83	dominici	dominici	PROPN
bam-7218	1243	84	c	c	NOUN
bam-7218	1243	85	,	,	PUNCT
bam-7218	1243	86	220	220	NUM
bam-7218	1243	87	donato	donato	NOUN
bam-7218	1243	88	r	r	NOUN
bam-7218	1243	89	,	,	PUNCT
bam-7218	1243	90	212,220	212,220	NUM
bam-7218	1243	91	duelen	duelen	ADJ
bam-7218	1243	92	r	r	NOUN
bam-7218	1243	93	,	,	PUNCT
bam-7218	1243	94	203,207,207	203,207,207	NUM
bam-7218	1243	95	dyar	dyar	PROPN
bam-7218	1243	96	ka	ka	PROPN
bam-7218	1243	97	,	,	PUNCT
bam-7218	1243	98	201	201	NUM
bam-7218	1243	99	elvassore	elvassore	NOUN
bam-7218	1243	100	n	n	CCONJ
bam-7218	1243	101	,	,	PUNCT
bam-7218	1243	102	188,196	188,196	NUM
bam-7218	1243	103	erratico	erratico	PROPN
bam-7218	1243	104	s	s	PROPN
bam-7218	1243	105	,	,	PUNCT
bam-7218	1243	106	205	205	NUM
bam-7218	1243	107	faggi	faggi	ADJ
bam-7218	1243	108	f	f	NOUN
bam-7218	1243	109	,	,	PUNCT
bam-7218	1243	110	218	218	NUM
bam-7218	1243	111	falcieri	falcieri	ADJ
bam-7218	1243	112	e	e	NOUN
bam-7218	1243	113	,	,	PUNCT
bam-7218	1243	114	211	211	NUM
bam-7218	1243	115	falcone	falcone	NOUN
bam-7218	1243	116	g	g	PROPN
bam-7218	1243	117	,	,	PUNCT
bam-7218	1243	118	199	199	NUM
bam-7218	1243	119	fanzani	fanzani	NOUN
bam-7218	1243	120	a	a	DET
bam-7218	1243	121	,	,	PUNCT
bam-7218	1243	122	205,211,218	205,211,218	NUM
bam-7218	1243	123	fardetti	fardetti	ADJ
bam-7218	1243	124	f	f	PROPN
bam-7218	1243	125	,	,	PUNCT
bam-7218	1243	126	213	213	NUM
bam-7218	1243	127	fecchio	fecchio	NOUN
bam-7218	1243	128	c	c	NOUN
bam-7218	1243	129	,	,	PUNCT
bam-7218	1243	130	200,203	200,203	NUM
bam-7218	1243	131	feno	feno	NOUN
bam-7218	1243	132	s	s	PROPN
bam-7218	1243	133	,	,	PUNCT
bam-7218	1243	134	214	214	NUM
bam-7218	1243	135	ferrar	ferrar	NOUN
bam-7218	1243	136	m	m	PROPN
bam-7218	1243	137	,	,	PUNCT
bam-7218	1243	138	219	219	NUM
bam-7218	1243	139	ferrara	ferrara	NOUN
bam-7218	1243	140	m	m	PROPN
bam-7218	1243	141	,	,	PUNCT
bam-7218	1243	142	208	208	NUM
bam-7218	1243	143	ferri	ferri	PROPN
bam-7218	1243	144	marini	marini	PROPN
bam-7218	1243	145	c	c	PROPN
bam-7218	1243	146	,	,	PUNCT
bam-7218	1243	147	213	213	NUM
bam-7218	1243	148	ferry	ferry	NOUN
bam-7218	1243	149	a	a	PRON
bam-7218	1243	150	,	,	PUNCT
bam-7218	1243	151	202	202	NUM
bam-7218	1243	152	filigheddu	filigheddu	ADJ
bam-7218	1243	153	n	n	CCONJ
bam-7218	1243	154	,	,	PUNCT
bam-7218	1243	155	208,208,219	208,208,219	NUM
bam-7218	1243	156	fimognari	fimognari	ADJ
bam-7218	1243	157	c	c	NOUN
bam-7218	1243	158	,	,	PUNCT
bam-7218	1243	159	220	220	NUM
bam-7218	1243	160	fonzino	fonzino	NOUN
bam-7218	1243	161	a	a	PRON
bam-7218	1243	162	,	,	PUNCT
bam-7218	1243	163	193	193	NUM
bam-7218	1243	164	forcina	forcina	NOUN
bam-7218	1243	165	l	l	NOUN
bam-7218	1243	166	,	,	PUNCT
bam-7218	1243	167	215,218	215,218	NUM
bam-7218	1243	168	forino	forino	NOUN
bam-7218	1243	169	m	m	PROPN
bam-7218	1243	170	,	,	PUNCT
bam-7218	1243	171	215	215	NUM
bam-7218	1243	172	fornetti	fornetti	ADJ
bam-7218	1243	173	e	e	NOUN
bam-7218	1243	174	,	,	PUNCT
bam-7218	1243	175	195	195	NUM
bam-7218	1243	176	fortunato	fortunato	PROPN
bam-7218	1243	177	a	a	X
bam-7218	1243	178	,	,	PUNCT
bam-7218	1243	179	223	223	NUM
bam-7218	1243	180	fossati	fossati	NOUN
bam-7218	1243	181	g	g	NOUN
bam-7218	1243	182	,	,	PUNCT
bam-7218	1243	183	215	215	NUM
bam-7218	1243	184	franco	franco	PROPN
bam-7218	1243	185	-	-	PUNCT
bam-7218	1243	186	romero	romero	PROPN
bam-7218	1243	187	a	a	PRON
bam-7218	1243	188	,	,	PUNCT
bam-7218	1243	189	190	190	NUM
bam-7218	1243	190	frati	frati	NOUN
bam-7218	1243	191	a	a	PRON
bam-7218	1243	192	,	,	PUNCT
bam-7218	1243	193	223	223	NUM
bam-7218	1243	194	frattini	frattini	ADJ
bam-7218	1243	195	p	p	NOUN
bam-7218	1243	196	,	,	PUNCT
bam-7218	1243	197	205	205	NUM
bam-7218	1243	198	mailto:elisabetta.meacci@unifi.it	mailto:elisabetta.meacci@unifi.it	PROPN
bam-7218	1243	199	14	14	NUM
bam-7218	1243	200	th	th	NOUN
bam-7218	1243	201	iiim	iiim	NOUN
bam-7218	1243	202	meeting	meeting	NOUN
bam-7218	1243	203	,	,	PUNCT
bam-7218	1243	204	assisi	assisi	PROPN
bam-7218	1243	205	,	,	PUNCT
bam-7218	1243	206	italy	italy	PROPN
bam-7218	1243	207	october	october	PROPN
bam-7218	1243	208	12	12	NUM
bam-7218	1243	209	-	-	SYM
bam-7218	1243	210	15	15	NUM
bam-7218	1243	211	2017	2017	NUM
bam-7218	1243	212	eur	eur	PROPN
bam-7218	1243	213	j	j	PROPN
bam-7218	1243	214	transl	transl	PROPN
bam-7218	1243	215	myol	myol	ADV
bam-7218	1243	216	27	27	NUM
bam-7218	1243	217	(	(	PUNCT
bam-7218	1243	218	4	4	NUM
bam-7218	1243	219	):	):	SYM
bam-7218	1243	220	185	185	NUM
bam-7218	1243	221	-	-	SYM
bam-7218	1243	222	224	224	NUM
bam-7218	1243	223	224	224	NUM
bam-7218	1243	224	freier	freier	NOUN
bam-7218	1243	225	e	e	PROPN
bam-7218	1243	226	,	,	PUNCT
bam-7218	1243	227	217	217	NUM
bam-7218	1243	228	fulle	fulle	VERB
bam-7218	1243	229	s	s	NOUN
bam-7218	1243	230	,	,	PUNCT
bam-7218	1243	231	196,207,207,214,220	196,207,207,214,220	NUM
bam-7218	1243	232	fuoco	fuoco	NOUN
bam-7218	1243	233	c	c	NOUN
bam-7218	1243	234	,	,	PUNCT
bam-7218	1243	235	195,201,216	195,201,216	NUM
bam-7218	1243	236	furling	furl	VERB
bam-7218	1243	237	d	d	NOUN
bam-7218	1243	238	,	,	PUNCT
bam-7218	1243	239	191	191	NUM
bam-7218	1243	240	fusella	fusella	NOUN
bam-7218	1243	241	a	a	PRON
bam-7218	1243	242	,	,	PUNCT
bam-7218	1243	243	222	222	NUM
bam-7218	1243	244	galletta	galletta	NOUN
bam-7218	1243	245	e	e	NOUN
bam-7218	1243	246	,	,	PUNCT
bam-7218	1243	247	197	197	NUM
bam-7218	1243	248	gargioli	gargioli	NOUN
bam-7218	1243	249	c	c	NOUN
bam-7218	1243	250	,	,	PUNCT
bam-7218	1243	251	195,197,201,216	195,197,201,216	NUM
bam-7218	1243	252	gavazzi	gavazzi	NOUN
bam-7218	1243	253	s	s	PROPN
bam-7218	1243	254	,	,	PUNCT
bam-7218	1243	255	211	211	NUM
bam-7218	1243	256	gawor	gawor	NOUN
bam-7218	1243	257	m	m	PROPN
bam-7218	1243	258	,	,	PUNCT
bam-7218	1243	259	189,216	189,216	NUM
bam-7218	1243	260	germinario	germinario	NOUN
bam-7218	1243	261	e	e	NOUN
bam-7218	1243	262	,	,	PUNCT
bam-7218	1243	263	203	203	NUM
bam-7218	1243	264	gervasi	gervasi	PROPN
bam-7218	1243	265	m	m	PROPN
bam-7218	1243	266	,	,	PUNCT
bam-7218	1243	267	213	213	NUM
bam-7218	1243	268	gherardi	gherardi	NOUN
bam-7218	1243	269	g	g	NOUN
bam-7218	1243	270	,	,	PUNCT
bam-7218	1243	271	190,222	190,222	NUM
bam-7218	1243	272	gherardi	gherardi	NOUN
bam-7218	1243	273	r	r	NOUN
bam-7218	1243	274	,	,	PUNCT
bam-7218	1243	275	218	218	NUM
bam-7218	1243	276	giacomazzi	giacomazzi	NOUN
bam-7218	1243	277	g	g	NOUN
bam-7218	1243	278	,	,	PUNCT
bam-7218	1243	279	197,203,214	197,203,214	NUM
bam-7218	1243	280	giarratana	giarratana	NOUN
bam-7218	1243	281	n	n	CCONJ
bam-7218	1243	282	,	,	PUNCT
bam-7218	1243	283	207	207	NUM
bam-7218	1243	284	gilbert	gilbert	PROPN
bam-7218	1243	285	p	p	X
bam-7218	1243	286	,	,	PUNCT
bam-7218	1243	287	197	197	NUM
bam-7218	1243	288	gil	gil	PROPN
bam-7218	1243	289	-	-	PUNCT
bam-7218	1243	290	recio	recio	PROPN
bam-7218	1243	291	c	c	PROPN
bam-7218	1243	292	,	,	PUNCT
bam-7218	1243	293	204	204	NUM
bam-7218	1243	294	giovarelli	giovarelli	NOUN
bam-7218	1243	295	m	m	PROPN
bam-7218	1243	296	,	,	PUNCT
bam-7218	1243	297	190,195	190,195	NUM
bam-7218	1243	298	gobbi	gobbi	PROPN
bam-7218	1243	299	p	p	X
bam-7218	1243	300	,	,	PUNCT
bam-7218	1243	301	211	211	NUM
bam-7218	1243	302	gobbo	gobbo	NOUN
bam-7218	1243	303	v	v	NOUN
bam-7218	1243	304	,	,	PUNCT
bam-7218	1243	305	203	203	NUM
bam-7218	1243	306	gonzález	gonzález	PROPN
bam-7218	1243	307	-	-	PUNCT
bam-7218	1243	308	coraspe	coraspe	PROPN
bam-7218	1243	309	ja	ja	PROPN
bam-7218	1243	310	,	,	PUNCT
bam-7218	1243	311	217	217	NUM
bam-7218	1243	312	graf	graf	NOUN
bam-7218	1243	313	a	a	DET
bam-7218	1243	314	,	,	PUNCT
bam-7218	1243	315	188	188	NUM
bam-7218	1243	316	grassi	grassi	NOUN
bam-7218	1243	317	e	e	NOUN
bam-7218	1243	318	,	,	PUNCT
bam-7218	1243	319	213	213	NUM
bam-7218	1243	320	graziani	graziani	NOUN
bam-7218	1243	321	a	a	PRON
bam-7218	1243	322	,	,	PUNCT
bam-7218	1243	323	208,219	208,219	NUM
bam-7218	1243	324	greco	greco	PROPN
bam-7218	1243	325	e	e	PROPN
bam-7218	1243	326	,	,	PUNCT
bam-7218	1243	327	199	199	NUM
bam-7218	1243	328	guarnier	guarnier	ADJ
bam-7218	1243	329	fa	fa	NOUN
bam-7218	1243	330	,	,	PUNCT
bam-7218	1243	331	192,210	192,210	NUM
bam-7218	1243	332	guarnieri	guarnieri	PROPN
bam-7218	1243	333	s	s	PROPN
bam-7218	1243	334	,	,	PUNCT
bam-7218	1243	335	196	196	NUM
bam-7218	1243	336	guescini	guescini	NOUN
bam-7218	1243	337	m	m	PROPN
bam-7218	1243	338	,	,	PUNCT
bam-7218	1243	339	209	209	NUM
bam-7218	1243	340	guescini	guescini	NOUN
bam-7218	1243	341	m	m	PROPN
bam-7218	1243	342	,	,	PUNCT
bam-7218	1243	343	212,213,217	212,213,217	NUM
bam-7218	1243	344	hathazi	hathazi	NOUN
bam-7218	1243	345	d	d	NOUN
bam-7218	1243	346	,	,	PUNCT
bam-7218	1243	347	191,217	191,217	NUM
bam-7218	1243	348	herledan	herledan	NOUN
bam-7218	1243	349	g	g	NOUN
bam-7218	1243	350	,	,	PUNCT
bam-7218	1243	351	202	202	NUM
bam-7218	1243	352	höfer	höfer	VERB
bam-7218	1243	353	c	c	NOUN
bam-7218	1243	354	,	,	PUNCT
bam-7218	1243	355	222	222	NUM
bam-7218	1243	356	holvoet	holvoet	VERB
bam-7218	1243	357	b	b	NOUN
bam-7218	1243	358	,	,	PUNCT
bam-7218	1243	359	203	203	NUM
bam-7218	1243	360	horvath	horvath	PROPN
bam-7218	1243	361	r	r	PROPN
bam-7218	1243	362	,	,	PUNCT
bam-7218	1243	363	204,204	204,204	NUM
bam-7218	1243	364	huylebroeck	huylebroeck	NOUN
bam-7218	1243	365	d	d	NOUN
bam-7218	1243	366	,	,	PUNCT
bam-7218	1243	367	214	214	NUM
bam-7218	1243	368	iannuzzi	iannuzzi	NOUN
bam-7218	1243	369	a	a	PRON
bam-7218	1243	370	,	,	PUNCT
bam-7218	1243	371	210	210	NUM
bam-7218	1243	372	innocenzi	innocenzi	NOUN
bam-7218	1243	373	a	a	PRON
bam-7218	1243	374	,	,	PUNCT
bam-7218	1243	375	218	218	NUM
bam-7218	1243	376	irving	irving	PROPN
bam-7218	1243	377	t	t	PROPN
bam-7218	1243	378	,	,	PUNCT
bam-7218	1243	379	213	213	NUM
bam-7218	1243	380	isham	isham	PROPN
bam-7218	1243	381	a	a	PRON
bam-7218	1243	382	,	,	PUNCT
bam-7218	1243	383	191	191	NUM
bam-7218	1243	384	jimenez	jimenez	PROPN
bam-7218	1243	385	-	-	PUNCT
bam-7218	1243	386	moreno	moreno	PROPN
bam-7218	1243	387	ac	ac	PROPN
bam-7218	1243	388	,	,	PUNCT
bam-7218	1243	389	191	191	NUM
bam-7218	1243	390	joureau	joureau	PROPN
bam-7218	1243	391	b	b	PROPN
bam-7218	1243	392	,	,	PUNCT
bam-7218	1243	393	213	213	NUM
bam-7218	1243	394	kern	kern	PROPN
bam-7218	1243	395	h	h	NOUN
bam-7218	1243	396	,	,	PUNCT
bam-7218	1243	397	222	222	NUM
bam-7218	1243	398	kiselyov	kiselyov	NOUN
bam-7218	1243	399	a	a	ADP
bam-7218	1243	400	,	,	PUNCT
bam-7218	1243	401	200	200	NUM
bam-7218	1243	402	kok	kok	PROPN
bam-7218	1243	403	hj	hj	PROPN
bam-7218	1243	404	,	,	PUNCT
bam-7218	1243	405	197	197	NUM
bam-7218	1243	406	krebs	krebs	NOUN
bam-7218	1243	407	s	s	PROPN
bam-7218	1243	408	,	,	PUNCT
bam-7218	1243	409	198	198	NUM
bam-7218	1243	410	kruger	kruger	PROPN
bam-7218	1243	411	m	m	PROPN
bam-7218	1243	412	,	,	PUNCT
bam-7218	1243	413	201	201	NUM
bam-7218	1243	414	la	la	DET
bam-7218	1243	415	rovere	rovere	NOUN
bam-7218	1243	416	rml	rml	NOUN
bam-7218	1243	417	,	,	PUNCT
bam-7218	1243	418	196	196	NUM
bam-7218	1243	419	lafuste	lafuste	VERB
bam-7218	1243	420	p	p	NOUN
bam-7218	1243	421	,	,	PUNCT
bam-7218	1243	422	218	218	NUM
bam-7218	1243	423	lapi	lapi	NOUN
bam-7218	1243	424	m	m	PROPN
bam-7218	1243	425	,	,	PUNCT
bam-7218	1243	426	192	192	NUM
bam-7218	1243	427	lassche	lassche	NOUN
bam-7218	1243	428	s	s	PROPN
bam-7218	1243	429	,	,	PUNCT
bam-7218	1243	430	213	213	NUM
bam-7218	1243	431	legnini	legnini	PROPN
bam-7218	1243	432	i	i	PRON
bam-7218	1243	433	,	,	PUNCT
bam-7218	1243	434	220	220	NUM
bam-7218	1243	435	liantonio	liantonio	NOUN
bam-7218	1243	436	a	a	DET
bam-7218	1243	437	,	,	PUNCT
bam-7218	1243	438	193	193	NUM
bam-7218	1243	439	linari	linari	NOUN
bam-7218	1243	440	m	m	SYM
bam-7218	1243	441	,	,	PUNCT
bam-7218	1243	442	188	188	NUM
bam-7218	1243	443	lochmüller	lochmüller	NOUN
bam-7218	1243	444	h	h	NOUN
bam-7218	1243	445	,	,	PUNCT
bam-7218	1243	446	191,191,198	191,191,198	NUM
bam-7218	1243	447	,	,	PUNCT
bam-7218	1243	448	204,217	204,217	NUM
bam-7218	1243	449	löfler	löfler	NOUN
bam-7218	1243	450	s	s	NOUN
bam-7218	1243	451	,	,	PUNCT
bam-7218	1243	452	222	222	NUM
bam-7218	1243	453	lorenz	lorenz	PROPN
bam-7218	1243	454	k	k	PROPN
bam-7218	1243	455	,	,	PUNCT
bam-7218	1243	456	198	198	NUM
bam-7218	1243	457	low	low	ADJ
bam-7218	1243	458	manilla	manilla	NOUN
bam-7218	1243	459	m	m	PRON
bam-7218	1243	460	,	,	PUNCT
bam-7218	1243	461	198	198	NUM
bam-7218	1243	462	lu	lu	NOUN
bam-7218	1243	463	q	q	NOUN
bam-7218	1243	464	,	,	PUNCT
bam-7218	1243	465	205	205	NUM
bam-7218	1243	466	luca	luca	PROPN
bam-7218	1243	467	g	g	NOUN
bam-7218	1243	468	,	,	PUNCT
bam-7218	1243	469	220	220	NUM
bam-7218	1243	470	lucertini	lucertini	NOUN
bam-7218	1243	471	f	f	PROPN
bam-7218	1243	472	,	,	PUNCT
bam-7218	1243	473	212,213	212,213	NUM
bam-7218	1243	474	lugarini	lugarini	VERB
bam-7218	1243	475	f	f	PROPN
bam-7218	1243	476	,	,	PUNCT
bam-7218	1243	477	221	221	NUM
bam-7218	1243	478	luttun	luttun	NOUN
bam-7218	1243	479	a	a	PRON
bam-7218	1243	480	,	,	PUNCT
bam-7218	1243	481	204	204	NUM
bam-7218	1243	482	madaro	madaro	NOUN
bam-7218	1243	483	l	l	NOUN
bam-7218	1243	484	,	,	PUNCT
bam-7218	1243	485	197	197	NUM
bam-7218	1243	486	maggio	maggio	NOUN
bam-7218	1243	487	s	s	PART
bam-7218	1243	488	,	,	PUNCT
bam-7218	1243	489	212,213,217	212,213,217	NUM
bam-7218	1243	490	maiole	maiole	NOUN
bam-7218	1243	491	f	f	PROPN
bam-7218	1243	492	,	,	PUNCT
bam-7218	1243	493	194	194	NUM
bam-7218	1243	494	mammucari	mammucari	PROPN
bam-7218	1243	495	c	c	NOUN
bam-7218	1243	496	,	,	PUNCT
bam-7218	1243	497	190,222	190,222	NUM
bam-7218	1243	498	mancinelli	mancinelli	ADJ
bam-7218	1243	499	r	r	NOUN
bam-7218	1243	500	,	,	PUNCT
bam-7218	1243	501	196	196	NUM
bam-7218	1243	502	mancuso	mancuso	X
bam-7218	1243	503	f	f	PROPN
bam-7218	1243	504	,	,	PUNCT
bam-7218	1243	505	220	220	NUM
bam-7218	1243	506	mandla	mandla	NOUN
bam-7218	1243	507	s	s	NOUN
bam-7218	1243	508	,	,	PUNCT
bam-7218	1243	509	197	197	NUM
bam-7218	1243	510	mann	mann	PROPN
bam-7218	1243	511	m	m	PROPN
bam-7218	1243	512	,	,	PUNCT
bam-7218	1243	513	201	201	NUM
bam-7218	1243	514	marabita	marabita	NOUN
bam-7218	1243	515	m	m	PROPN
bam-7218	1243	516	,	,	PUNCT
bam-7218	1243	517	213	213	NUM
bam-7218	1243	518	marchini	marchini	NOUN
bam-7218	1243	519	s	s	NOUN
bam-7218	1243	520	,	,	PUNCT
bam-7218	1243	521	206	206	NUM
bam-7218	1243	522	marinkovic	marinkovic	PROPN
bam-7218	1243	523	m	m	PROPN
bam-7218	1243	524	,	,	PUNCT
bam-7218	1243	525	201	201	NUM
bam-7218	1243	526	marroncelli	marroncelli	NOUN
bam-7218	1243	527	n	n	CCONJ
bam-7218	1243	528	,	,	PUNCT
bam-7218	1243	529	194	194	NUM
bam-7218	1243	530	marrone	marrone	PROPN
bam-7218	1243	531	m	m	PROPN
bam-7218	1243	532	,	,	PUNCT
bam-7218	1243	533	196	196	NUM
bam-7218	1243	534	martelli	martelli	PROPN
bam-7218	1243	535	f	f	X
bam-7218	1243	536	,	,	PUNCT
bam-7218	1243	537	199	199	NUM
bam-7218	1243	538	martinelli	martinelli	PROPN
bam-7218	1243	539	gb	gb	PROPN
bam-7218	1243	540	,	,	PUNCT
bam-7218	1243	541	206	206	NUM
bam-7218	1243	542	martínez	martínez	NOUN
bam-7218	1243	543	-	-	PUNCT
bam-7218	1243	544	sarrà	sarrà	PROPN
bam-7218	1243	545	e	e	NOUN
bam-7218	1243	546	,	,	PUNCT
bam-7218	1243	547	204,207	204,207	NUM
bam-7218	1243	548	matteini	matteini	NOUN
bam-7218	1243	549	f	f	NOUN
bam-7218	1243	550	,	,	PUNCT
bam-7218	1243	551	223	223	NUM
bam-7218	1243	552	mcmacken	mcmacken	VERB
bam-7218	1243	553	g	g	PROPN
bam-7218	1243	554	,	,	PUNCT
bam-7218	1243	555	204	204	NUM
bam-7218	1243	556	meacci	meacci	NOUN
bam-7218	1243	557	e	e	NOUN
bam-7218	1243	558	,	,	PUNCT
bam-7218	1243	559	223	223	NUM
bam-7218	1243	560	megiorni	megiorni	PROPN
bam-7218	1243	561	f	f	PROPN
bam-7218	1243	562	,	,	PUNCT
bam-7218	1243	563	220	220	NUM
bam-7218	1243	564	mele	mele	PROPN
bam-7218	1243	565	a	a	PRON
bam-7218	1243	566	,	,	PUNCT
bam-7218	1243	567	193	193	NUM
bam-7218	1243	568	meola	meola	PROPN
bam-7218	1243	569	g	g	PROPN
bam-7218	1243	570	,	,	PUNCT
bam-7218	1243	571	199	199	NUM
bam-7218	1243	572	meregalli	meregalli	NOUN
bam-7218	1243	573	m	m	PROPN
bam-7218	1243	574	,	,	PUNCT
bam-7218	1243	575	205	205	NUM
bam-7218	1243	576	mésséant	mésséant	PROPN
bam-7218	1243	577	j	j	PROPN
bam-7218	1243	578	,	,	PUNCT
bam-7218	1243	579	202	202	NUM
bam-7218	1243	580	messina	messina	PROPN
bam-7218	1243	581	g	g	PROPN
bam-7218	1243	582	,	,	PUNCT
bam-7218	1243	583	192,192,200,218	192,192,200,218	NUM
bam-7218	1243	584	miano	miano	PROPN
bam-7218	1243	585	c	c	NOUN
bam-7218	1243	586	,	,	PUNCT
bam-7218	1243	587	215,218	215,218	NUM
bam-7218	1243	588	michels	michel	NOUN
bam-7218	1243	589	h	h	NOUN
bam-7218	1243	590	,	,	PUNCT
bam-7218	1243	591	217	217	NUM
bam-7218	1243	592	michelucci	michelucci	VERB
bam-7218	1243	593	a	a	PRON
bam-7218	1243	594	,	,	PUNCT
bam-7218	1243	595	193	193	NUM
bam-7218	1243	596	milan	milan	PROPN
bam-7218	1243	597	g	g	PROPN
bam-7218	1243	598	,	,	PUNCT
bam-7218	1243	599	190	190	NUM
bam-7218	1243	600	molenaar	molenaar	PROPN
bam-7218	1243	601	j	j	PROPN
bam-7218	1243	602	,	,	PUNCT
bam-7218	1243	603	213	213	NUM
bam-7218	1243	604	monteverde	monteverde	PROPN
bam-7218	1243	605	s	s	PROPN
bam-7218	1243	606	,	,	PUNCT
bam-7218	1243	607	192,218	192,218	NUM
bam-7218	1243	608	montori	montori	NOUN
bam-7218	1243	609	s	s	PROPN
bam-7218	1243	610	,	,	PUNCT
bam-7218	1243	611	204	204	NUM
bam-7218	1243	612	moresi	moresi	NOUN
bam-7218	1243	613	v	v	NOUN
bam-7218	1243	614	,	,	PUNCT
bam-7218	1243	615	194,199	194,199	NUM
bam-7218	1243	616	mozzetta	mozzetta	NOUN
bam-7218	1243	617	c	c	NOUN
bam-7218	1243	618	,	,	PUNCT
bam-7218	1243	619	198	198	NUM
bam-7218	1243	620	mulas	mula	NOUN
bam-7218	1243	621	f	f	PROPN
bam-7218	1243	622	,	,	PUNCT
bam-7218	1243	623	202	202	NUM
bam-7218	1243	624	munari	munari	ADJ
bam-7218	1243	625	f	f	X
bam-7218	1243	626	,	,	PUNCT
bam-7218	1243	627	214	214	NUM
bam-7218	1243	628	muñoz	muñoz	NOUN
bam-7218	1243	629	-	-	PUNCT
bam-7218	1243	630	cánoves	cánove	NOUN
bam-7218	1243	631	p	p	NOUN
bam-7218	1243	632	,	,	PUNCT
bam-7218	1243	633	198	198	NUM
bam-7218	1243	634	musarò	musarò	NOUN
bam-7218	1243	635	a	a	PRON
bam-7218	1243	636	,	,	PUNCT
bam-7218	1243	637	193,209,215,218	193,209,215,218	NUM
bam-7218	1243	638	,	,	PUNCT
bam-7218	1243	639	219,222	219,222	NUM
bam-7218	1243	640	nardo	nardo	NOUN
bam-7218	1243	641	g	g	PROPN
bam-7218	1243	642	,	,	PUNCT
bam-7218	1243	643	206	206	NUM
bam-7218	1243	644	nicoletti	nicoletti	NOUN
bam-7218	1243	645	c	c	NOUN
bam-7218	1243	646	,	,	PUNCT
bam-7218	1243	647	209,215,218	209,215,218	NUM
bam-7218	1243	648	niewiadomski	niewiadomski	NOUN
bam-7218	1243	649	p	p	X
bam-7218	1243	650	,	,	PUNCT
bam-7218	1243	651	189,216	189,216	NUM
bam-7218	1243	652	nikolenko	nikolenko	PROPN
bam-7218	1243	653	n	n	NUM
bam-7218	1243	654	,	,	PUNCT
bam-7218	1243	655	191	191	NUM
bam-7218	1243	656	nogara	nogara	NOUN
bam-7218	1243	657	l	l	NOUN
bam-7218	1243	658	,	,	PUNCT
bam-7218	1243	659	201	201	NUM
bam-7218	1243	660	núñez	núñez	NOUN
bam-7218	1243	661	-	-	PUNCT
bam-7218	1243	662	toldrà	toldrà	NOUN
bam-7218	1243	663	r	r	NOUN
bam-7218	1243	664	,	,	PUNCT
bam-7218	1243	665	204	204	NUM
bam-7218	1243	666	o´connor	o´connor	ADJ
bam-7218	1243	667	e	e	NOUN
bam-7218	1243	668	,	,	PUNCT
bam-7218	1243	669	191,191	191,191	NUM
bam-7218	1243	670	olivari	olivari	NOUN
bam-7218	1243	671	d	d	NOUN
bam-7218	1243	672	,	,	PUNCT
bam-7218	1243	673	206	206	NUM
bam-7218	1243	674	ottenheijm	ottenheijm	ADJ
bam-7218	1243	675	c	c	NOUN
bam-7218	1243	676	,	,	PUNCT
bam-7218	1243	677	213	213	NUM
bam-7218	1243	678	owens	owen	NOUN
bam-7218	1243	679	d	d	X
bam-7218	1243	680	,	,	PUNCT
bam-7218	1243	681	202	202	NUM
bam-7218	1243	682	palacios	palacio	NOUN
bam-7218	1243	683	d	d	NOUN
bam-7218	1243	684	,	,	PUNCT
bam-7218	1243	685	194	194	NUM
bam-7218	1243	686	pasetto	pasetto	PROPN
bam-7218	1243	687	l	l	NOUN
bam-7218	1243	688	,	,	PUNCT
bam-7218	1243	689	206	206	NUM
bam-7218	1243	690	pasut	pasut	PROPN
bam-7218	1243	691	a	a	DET
bam-7218	1243	692	,	,	PUNCT
bam-7218	1243	693	198	198	NUM
bam-7218	1243	694	pecorai	pecorai	NOUN
bam-7218	1243	695	c	c	NOUN
bam-7218	1243	696	,	,	PUNCT
bam-7218	1243	697	193,210	193,210	NUM
bam-7218	1243	698	pellegrino	pellegrino	PROPN
bam-7218	1243	699	ma	ma	PROPN
bam-7218	1243	700	,	,	PUNCT
bam-7218	1243	701	211	211	NUM
bam-7218	1243	702	pelosi	pelosi	NOUN
bam-7218	1243	703	l	l	NOUN
bam-7218	1243	704	,	,	PUNCT
bam-7218	1243	705	215,218,219	215,218,219	NUM
bam-7218	1243	706	penna	penna	PROPN
bam-7218	1243	707	f	f	PROPN
bam-7218	1243	708	,	,	PUNCT
bam-7218	1243	709	210	210	NUM
bam-7218	1243	710	perdiguero	perdiguero	ADJ
bam-7218	1243	711	e	e	NOUN
bam-7218	1243	712	,	,	PUNCT
bam-7218	1243	713	198	198	NUM
bam-7218	1243	714	perin	perin	NOUN
bam-7218	1243	715	s	s	NOUN
bam-7218	1243	716	,	,	PUNCT
bam-7218	1243	717	196	196	NUM
bam-7218	1243	718	périou	périou	NOUN
bam-7218	1243	719	b	b	NOUN
bam-7218	1243	720	,	,	PUNCT
bam-7218	1243	721	218	218	NUM
bam-7218	1243	722	perrotta	perrotta	PROPN
bam-7218	1243	723	c,195	c,195	PROPN
bam-7218	1243	724	petrilli	petrilli	PROPN
bam-7218	1243	725	l	l	PROPN
bam-7218	1243	726	,	,	PUNCT
bam-7218	1243	727	201,216	201,216	NUM
bam-7218	1243	728	petrillo	petrillo	NOUN
bam-7218	1243	729	s	s	PROPN
bam-7218	1243	730	,	,	PUNCT
bam-7218	1243	731	229	229	NUM
bam-7218	1243	732	petrini	petrini	NOUN
bam-7218	1243	733	s	s	PROPN
bam-7218	1243	734	,	,	PUNCT
bam-7218	1243	735	229	229	NUM
bam-7218	1243	736	petroni	petroni	NOUN
bam-7218	1243	737	k	k	PROPN
bam-7218	1243	738	,	,	PUNCT
bam-7218	1243	739	200	200	NUM
bam-7218	1243	740	phan	phan	NOUN
bam-7218	1243	741	v	v	NOUN
bam-7218	1243	742	,	,	PUNCT
bam-7218	1243	743	191,198	191,198	NUM
bam-7218	1243	744	piccirillo	piccirillo	ADJ
bam-7218	1243	745	r	r	NOUN
bam-7218	1243	746	,	,	PUNCT
bam-7218	1243	747	206,206	206,206	NUM
bam-7218	1243	748	piemonte	piemonte	NOUN
bam-7218	1243	749	f	f	X
bam-7218	1243	750	,	,	PUNCT
bam-7218	1243	751	219	219	NUM
bam-7218	1243	752	pierno	pierno	NOUN
bam-7218	1243	753	s	s	PROPN
bam-7218	1243	754	,	,	PUNCT
bam-7218	1243	755	183	183	NUM
bam-7218	1243	756	pierucci	pierucci	NOUN
bam-7218	1243	757	f	f	X
bam-7218	1243	758	,	,	PUNCT
bam-7218	1243	759	223	223	NUM
bam-7218	1243	760	pietrangelo	pietrangelo	NOUN
bam-7218	1243	761	l	l	NOUN
bam-7218	1243	762	,	,	PUNCT
bam-7218	1243	763	192,193,222	192,193,222	NUM
bam-7218	1243	764	pigna	pigna	NOUN
bam-7218	1243	765	e	e	NOUN
bam-7218	1243	766	,	,	PUNCT
bam-7218	1243	767	199	199	NUM
bam-7218	1243	768	pin	pin	NOUN
bam-7218	1243	769	f	f	PROPN
bam-7218	1243	770	,	,	PUNCT
bam-7218	1243	771	210	210	NUM
bam-7218	1243	772	pinardi	pinardi	NOUN
bam-7218	1243	773	l	l	NOUN
bam-7218	1243	774	,	,	PUNCT
bam-7218	1243	775	218	218	NUM
bam-7218	1243	776	pogoryelova	pogoryelova	NOUN
bam-7218	1243	777	o	o	NOUN
bam-7218	1243	778	,	,	PUNCT
bam-7218	1243	779	191	191	NUM
bam-7218	1243	780	poli	poli	PROPN
bam-7218	1243	781	m	m	PROPN
bam-7218	1243	782	,	,	PUNCT
bam-7218	1243	783	205	205	NUM
bam-7218	1243	784	polidori	polidori	NOUN
bam-7218	1243	785	e	e	NOUN
bam-7218	1243	786	,	,	PUNCT
bam-7218	1243	787	212	212	NUM
bam-7218	1243	788	porporato	porporato	NOUN
bam-7218	1243	789	pe	pe	NOUN
bam-7218	1243	790	,	,	PUNCT
bam-7218	1243	791	222	222	NUM
bam-7218	1243	792	pradhan	pradhan	PROPN
bam-7218	1243	793	bs	b	NOUN
bam-7218	1243	794	,	,	PUNCT
bam-7218	1243	795	189,216	189,216	NUM
bam-7218	1243	796	previdi	previdi	NOUN
bam-7218	1243	797	s	s	PROPN
bam-7218	1243	798	,	,	PUNCT
bam-7218	1243	799	206	206	NUM
bam-7218	1243	800	prodam	prodam	NOUN
bam-7218	1243	801	f	f	X
bam-7218	1243	802	,	,	PUNCT
bam-7218	1243	803	208	208	NUM
bam-7218	1243	804	prószyński	prószyński	NOUN
bam-7218	1243	805	tj	tj	NOUN
bam-7218	1243	806	,	,	PUNCT
bam-7218	1243	807	189,226	189,226	NUM
bam-7218	1243	808	protasi	protasi	NOUN
bam-7218	1243	809	f	f	PROPN
bam-7218	1243	810	,	,	PUNCT
bam-7218	1243	811	192,193,210,222	192,193,210,222	NUM
bam-7218	1243	812	protasiuk	protasiuk	NOUN
bam-7218	1243	813	a	a	DET
bam-7218	1243	814	,	,	PUNCT
bam-7218	1243	815	216	216	NUM
bam-7218	1243	816	provenzano	provenzano	ADJ
bam-7218	1243	817	c	c	NOUN
bam-7218	1243	818	,	,	PUNCT
bam-7218	1243	819	199	199	NUM
bam-7218	1243	820	puri	puri	PROPN
bam-7218	1243	821	pl	pl	PROPN
bam-7218	1243	822	,	,	PUNCT
bam-7218	1243	823	194,221	194,221	NUM
bam-7218	1243	824	raffaello	raffaello	NOUN
bam-7218	1243	825	a	a	NOUN
bam-7218	1243	826	,	,	PUNCT
bam-7218	1243	827	203,214	203,214	NUM
bam-7218	1243	828	raimondi	raimondi	PROPN
bam-7218	1243	829	mt	mt	PROPN
bam-7218	1243	830	,	,	PUNCT
bam-7218	1243	831	205	205	NUM
bam-7218	1243	832	rao	rao	PROPN
bam-7218	1243	833	l	l	NOUN
bam-7218	1243	834	,	,	PUNCT
bam-7218	1243	835	209	209	NUM
bam-7218	1243	836	re	re	NOUN
bam-7218	1243	837	cecconi	cecconi	PROPN
bam-7218	1243	838	ad	ad	NOUN
bam-7218	1243	839	,	,	PUNCT
bam-7218	1243	840	206	206	NUM
bam-7218	1243	841	reano	reano	VERB
bam-7218	1243	842	a	a	PRON
bam-7218	1243	843	,	,	PUNCT
bam-7218	1243	844	219	219	NUM
bam-7218	1243	845	reano	reano	NOUN
bam-7218	1243	846	s	s	NOUN
bam-7218	1243	847	,	,	PUNCT
bam-7218	1243	848	208,208	208,208	NUM
bam-7218	1243	849	rędowicz	rędowicz	ADJ
bam-7218	1243	850	mj	mj	PROPN
bam-7218	1243	851	,	,	PUNCT
bam-7218	1243	852	216	216	NUM
bam-7218	1243	853	relaix	relaix	PROPN
bam-7218	1243	854	f	f	PROPN
bam-7218	1243	855	,	,	PUNCT
bam-7218	1243	856	196,218	196,218	NUM
bam-7218	1243	857	rickard	rickard	NOUN
bam-7218	1243	858	a	a	NOUN
bam-7218	1243	859	,	,	PUNCT
bam-7218	1243	860	209	209	NUM
bam-7218	1243	861	rickard	rickard	PROPN
bam-7218	1243	862	am	be	AUX
bam-7218	1243	863	,	,	PUNCT
bam-7218	1243	864	200	200	NUM
bam-7218	1243	865	rigolet	rigolet	NOUN
bam-7218	1243	866	m	m	PROPN
bam-7218	1243	867	,	,	PUNCT
bam-7218	1243	868	218	218	NUM
bam-7218	1243	869	ritso	ritso	PROPN
bam-7218	1243	870	m	m	PROPN
bam-7218	1243	871	,	,	PUNCT
bam-7218	1243	872	198	198	NUM
bam-7218	1243	873	riuzzi	riuzzi	NOUN
bam-7218	1243	874	f	f	NOUN
bam-7218	1243	875	,	,	PUNCT
bam-7218	1243	876	212,220	212,220	NUM
bam-7218	1243	877	rizzuto	rizzuto	NOUN
bam-7218	1243	878	r	r	NOUN
bam-7218	1243	879	,	,	PUNCT
bam-7218	1243	880	190,203,214	190,203,214	NUM
bam-7218	1243	881	212	212	NUM
bam-7218	1243	882	romanello	romanello	ADJ
bam-7218	1243	883	v	v	NOUN
bam-7218	1243	884	,	,	PUNCT
bam-7218	1243	885	190,222	190,222	NUM
bam-7218	1243	886	ronca	ronca	NOUN
bam-7218	1243	887	r	r	NOUN
bam-7218	1243	888	,	,	PUNCT
bam-7218	1243	889	218	218	NUM
bam-7218	1243	890	ronzoni	ronzoni	NOUN
bam-7218	1243	891	,	,	PUNCT
bam-7218	1243	892	fl	fl	PROPN
bam-7218	1243	893	202	202	NUM
bam-7218	1243	894	roos	roo	NOUN
bam-7218	1243	895	a	a	PRON
bam-7218	1243	896	,	,	PUNCT
bam-7218	1243	897	191,191,198	191,191,198	NUM
bam-7218	1243	898	204,217	204,217	NUM
bam-7218	1243	899	rosina	rosina	PROPN
bam-7218	1243	900	m	m	PROPN
bam-7218	1243	901	,	,	PUNCT
bam-7218	1243	902	201	201	NUM
bam-7218	1243	903	rossi	rossi	ADJ
bam-7218	1243	904	f	f	X
bam-7218	1243	905	,	,	PUNCT
bam-7218	1243	906	198,220	198,220	NUM
bam-7218	1243	907	rossi	rossi	ADJ
bam-7218	1243	908	g	g	PROPN
bam-7218	1243	909	,	,	PUNCT
bam-7218	1243	910	192,218	192,218	NUM
bam-7218	1243	911	rotini	rotini	NOUN
bam-7218	1243	912	a	a	ADP
bam-7218	1243	913	,	,	PUNCT
bam-7218	1243	914	204,207	204,207	NUM
bam-7218	1243	915	ruas	ruas	PROPN
bam-7218	1243	916	j,189	j,189	ADP
bam-7218	1243	917	sacchetto	sacchetto	ADJ
bam-7218	1243	918	r	r	NOUN
bam-7218	1243	919	,	,	PUNCT
bam-7218	1243	920	200	200	NUM
bam-7218	1243	921	sacco	sacco	NOUN
bam-7218	1243	922	f	f	PROPN
bam-7218	1243	923	,	,	PUNCT
bam-7218	1243	924	201	201	NUM
bam-7218	1243	925	saccone	saccone	NOUN
bam-7218	1243	926	v	v	NOUN
bam-7218	1243	927	,	,	PUNCT
bam-7218	1243	928	194	194	NUM
bam-7218	1243	929	saclier	saclier	NOUN
bam-7218	1243	930	m	m	PROPN
bam-7218	1243	931	,	,	PUNCT
bam-7218	1243	932	192	192	NUM
bam-7218	1243	933	,	,	PUNCT
bam-7218	1243	934	200,218	200,218	NUM
bam-7218	1243	935	sagheddu	sagheddu	NOUN
bam-7218	1243	936	r	r	NOUN
bam-7218	1243	937	,	,	PUNCT
bam-7218	1243	938	212,220	212,220	NUM
bam-7218	1243	939	sahakyan	sahakyan	ADJ
bam-7218	1243	940	v	v	NOUN
bam-7218	1243	941	,	,	PUNCT
bam-7218	1243	942	203	203	NUM
bam-7218	1243	943	saltarelli	saltarelli	ADJ
bam-7218	1243	944	r	r	NOUN
bam-7218	1243	945	,	,	PUNCT
bam-7218	1243	946	209	209	NUM
bam-7218	1243	947	salucci	salucci	NOUN
bam-7218	1243	948	s	s	PART
bam-7218	1243	949	,	,	PUNCT
bam-7218	1243	950	211	211	NUM
bam-7218	1243	951	salvadori	salvadori	PROPN
bam-7218	1243	952	l	l	NOUN
bam-7218	1243	953	,	,	PUNCT
bam-7218	1243	954	212,220	212,220	NUM
bam-7218	1243	955	sampaolesi	sampaolesi	NOUN
bam-7218	1243	956	m	m	PROPN
bam-7218	1243	957	,	,	PUNCT
bam-7218	1243	958	202,203,204	202,203,204	NUM
bam-7218	1243	959	,	,	PUNCT
bam-7218	1243	960	207,207,214	207,207,214	NUM
bam-7218	1243	961	sandonà	sandonà	NOUN
bam-7218	1243	962	d	d	NOUN
bam-7218	1243	963	,	,	PUNCT
bam-7218	1243	964	200,203	200,203	NUM
bam-7218	1243	965	sandri	sandri	PROPN
bam-7218	1243	966	m	m	NOUN
bam-7218	1243	967	,	,	PUNCT
bam-7218	1243	968	190,222,222	190,222,222	NUM
bam-7218	1243	969	sarabon	sarabon	NOUN
bam-7218	1243	970	n	n	CCONJ
bam-7218	1243	971	,	,	PUNCT
bam-7218	1243	972	222	222	NUM
bam-7218	1243	973	sartorelli	sartorelli	NOUN
bam-7218	1243	974	v	v	ADP
bam-7218	1243	975	,	,	PUNCT
bam-7218	1243	976	198	198	NUM
bam-7218	1243	977	sartori	sartori	NOUN
bam-7218	1243	978	r	r	NOUN
bam-7218	1243	979	,	,	PUNCT
bam-7218	1243	980	190	190	NUM
bam-7218	1243	981	schmidt	schmidt	PROPN
bam-7218	1243	982	u	u	NOUN
bam-7218	1243	983	,	,	PUNCT
bam-7218	1243	984	200,209	200,209	NUM
bam-7218	1243	985	serano	serano	PROPN
bam-7218	1243	986	m	m	PROPN
bam-7218	1243	987	,	,	PUNCT
bam-7218	1243	988	192	192	NUM
bam-7218	1243	989	serena	serena	NOUN
bam-7218	1243	990	e	e	NOUN
bam-7218	1243	991	,	,	PUNCT
bam-7218	1243	992	196	196	NUM
bam-7218	1243	993	sestili	sestili	NOUN
bam-7218	1243	994	p	p	X
bam-7218	1243	995	,	,	PUNCT
bam-7218	1243	996	220	220	NUM
bam-7218	1243	997	simonazzi	simonazzi	NOUN
bam-7218	1243	998	e	e	NOUN
bam-7218	1243	999	,	,	PUNCT
bam-7218	1243	1000	199	199	NUM
bam-7218	1243	1001	smith	smith	PROPN
bam-7218	1243	1002	l	l	PROPN
bam-7218	1243	1003	,	,	PUNCT
bam-7218	1243	1004	197	197	NUM
bam-7218	1243	1005	soardi	soardi	PROPN
bam-7218	1243	1006	m	m	PROPN
bam-7218	1243	1007	,	,	PUNCT
bam-7218	1243	1008	200,1203	200,1203	NUM
bam-7218	1243	1009	solagna	solagna	PROPN
bam-7218	1243	1010	f	f	X
bam-7218	1243	1011	,	,	PUNCT
bam-7218	1243	1012	201	201	NUM
bam-7218	1243	1013	sorci	sorci	VERB
bam-7218	1243	1014	g	g	ADP
bam-7218	1243	1015	,	,	PUNCT
bam-7218	1243	1016	212,220	212,220	NUM
bam-7218	1243	1017	spada	spada	PROPN
bam-7218	1243	1018	f	f	PROPN
bam-7218	1243	1019	,	,	PUNCT
bam-7218	1243	1020	201	201	NUM
bam-7218	1243	1021	spendiff	spendiff	NOUN
bam-7218	1243	1022	s	s	NOUN
bam-7218	1243	1023	,	,	PUNCT
bam-7218	1243	1024	204	204	NUM
bam-7218	1243	1025	steikuhler	steikuhler	NOUN
bam-7218	1243	1026	c	c	NOUN
bam-7218	1243	1027	,	,	PUNCT
bam-7218	1243	1028	215	215	NUM
bam-7218	1243	1029	sthandier	sthandier	NOUN
bam-7218	1243	1030	o	o	NOUN
bam-7218	1243	1031	,	,	PUNCT
bam-7218	1243	1032	220	220	NUM
bam-7218	1243	1033	stienen	stienen	NOUN
bam-7218	1243	1034	g	g	NOUN
bam-7218	1243	1035	,	,	PUNCT
bam-7218	1243	1036	213	213	NUM
bam-7218	1243	1037	stocchi	stocchi	PROPN
bam-7218	1243	1038	v	v	NOUN
bam-7218	1243	1039	,	,	PUNCT
bam-7218	1243	1040	209,212,213,217	209,212,213,217	NUM
bam-7218	1243	1041	sunada	sunada	PROPN
bam-7218	1243	1042	y	y	PROPN
bam-7218	1243	1043	,	,	PUNCT
bam-7218	1243	1044	217	217	NUM
bam-7218	1243	1045	sustova	sustova	VERB
bam-7218	1244	1	h	h	NOUN
bam-7218	1244	2	,	,	PUNCT
bam-7218	1244	3	208,219	208,219	NUM
bam-7218	1244	4	szabò	szabò	ADJ
bam-7218	1245	1	i	i	PRON
bam-7218	1245	2	,	,	PUNCT
bam-7218	1245	3	203	203	NUM
bam-7218	1245	4	taglietti	taglietti	NOUN
bam-7218	1245	5	v	v	NOUN
bam-7218	1245	6	,	,	PUNCT
bam-7218	1245	7	192,218	192,218	NUM
bam-7218	1245	8	tarnopolsky	tarnopolsky	NOUN
bam-7218	1245	9	m	m	PROPN
bam-7218	1245	10	,	,	PUNCT
bam-7218	1245	11	189	189	NUM
bam-7218	1245	12	testa	testa	PROPN
bam-7218	1245	13	s	s	SYM
bam-7218	1245	14	,	,	PUNCT
bam-7218	1245	15	195	195	NUM
bam-7218	1245	16	tibaudo	tibaudo	NOUN
bam-7218	1245	17	l	l	NOUN
bam-7218	1245	18	,	,	PUNCT
bam-7218	1245	19	197	197	NUM
bam-7218	1245	20	tonelli	tonelli	PROPN
bam-7218	1245	21	c	c	NOUN
bam-7218	1245	22	,	,	PUNCT
bam-7218	1245	23	200	200	NUM
bam-7218	1245	24	torrente	torrente	PROPN
bam-7218	1245	25	y	y	PROPN
bam-7218	1245	26	,	,	PUNCT
bam-7218	1245	27	205	205	NUM
bam-7218	1245	28	travaglini	travaglini	ADJ
bam-7218	1245	29	l	l	NOUN
bam-7218	1245	30	,	,	PUNCT
bam-7218	1245	31	219	219	NUM
bam-7218	1245	32	tricarico	tricarico	NOUN
bam-7218	1245	33	d	d	NOUN
bam-7218	1245	34	,	,	PUNCT
bam-7218	1245	35	193	193	NUM
bam-7218	1245	36	tucciarone	tucciarone	NOUN
bam-7218	1245	37	l	l	NOUN
bam-7218	1245	38	,	,	PUNCT
bam-7218	1245	39	221	221	NUM
bam-7218	1245	40	uhlenhaut	uhlenhaut	ADJ
bam-7218	1245	41	h	h	NOUN
bam-7218	1245	42	,	,	PUNCT
bam-7218	1245	43	201	201	NUM
bam-7218	1245	44	urbani	urbani	PROPN
bam-7218	1245	45	l	l	PROPN
bam-7218	1245	46	,	,	PUNCT
bam-7218	1245	47	196	196	NUM
bam-7218	1245	48	urciuolo	urciuolo	NOUN
bam-7218	1245	49	a	a	PRON
bam-7218	1245	50	,	,	PUNCT
bam-7218	1245	51	196	196	NUM
bam-7218	1245	52	valaperta	valaperta	NOUN
bam-7218	1245	53	r	r	NOUN
bam-7218	1245	54	,	,	PUNCT
bam-7218	1245	55	199	199	NUM
bam-7218	1245	56	vallese	vallese	NOUN
bam-7218	1245	57	f	f	X
bam-7218	1245	58	,	,	PUNCT
bam-7218	1245	59	203	203	NUM
bam-7218	1245	60	vallorani	vallorani	ADJ
bam-7218	1245	61	l	l	NOUN
bam-7218	1245	62	,	,	PUNCT
bam-7218	1245	63	209	209	NUM
bam-7218	1245	64	van	van	PROPN
bam-7218	1245	65	engelen	engelen	PROPN
bam-7218	1245	66	b	b	PROPN
bam-7218	1245	67	,	,	PUNCT
bam-7218	1245	68	213	213	NUM
bam-7218	1245	69	van	van	PROPN
bam-7218	1245	70	willigenburg	willigenburg	PROPN
bam-7218	1245	71	m	m	PROPN
bam-7218	1245	72	,	,	PUNCT
bam-7218	1245	73	213	213	NUM
bam-7218	1245	74	vecellio	vecellio	NOUN
bam-7218	1245	75	reane	reane	PROPN
bam-7218	1245	76	d	d	NOUN
bam-7218	1245	77	,	,	PUNCT
bam-7218	1245	78	203	203	NUM
bam-7218	1245	79	verardo	verardo	NOUN
bam-7218	1245	80	m	m	PROPN
bam-7218	1245	81	,	,	PUNCT
bam-7218	1245	82	219	219	NUM
bam-7218	1245	83	verhaart	verhaart	NOUN
bam-7218	1246	1	i	i	PRON
bam-7218	1246	2	,	,	PUNCT
bam-7218	1246	3	191	191	NUM
bam-7218	1246	4	villa	villa	PROPN
bam-7218	1246	5	c	c	PROPN
bam-7218	1246	6	,	,	PUNCT
bam-7218	1246	7	205	205	NUM
bam-7218	1246	8	viola	viola	NOUN
bam-7218	1246	9	a	a	X
bam-7218	1246	10	,	,	PUNCT
bam-7218	1246	11	214	214	NUM
bam-7218	1246	12	vissing	visse	VERB
bam-7218	1246	13	k	k	PROPN
bam-7218	1246	14	,	,	PUNCT
bam-7218	1246	15	201	201	NUM
bam-7218	1246	16	vitiello	vitiello	ADP
bam-7218	1246	17	l	l	NOUN
bam-7218	1246	18	,	,	PUNCT
bam-7218	1246	19	196,197	196,197	NUM
bam-7218	1246	20	voermans	voerman	NOUN
bam-7218	1246	21	n	n	CCONJ
bam-7218	1246	22	,	,	PUNCT
bam-7218	1246	23	13	13	NUM
bam-7218	1246	24	weis	weis	PROPN
bam-7218	1246	25	j	j	PROPN
bam-7218	1246	26	,	,	PUNCT
bam-7218	1246	27	217	217	NUM
bam-7218	1246	28	wyart	wyart	NOUN
bam-7218	1246	29	e	e	NOUN
bam-7218	1246	30	,	,	PUNCT
bam-7218	1246	31	222	222	NUM
bam-7218	1246	32	zahedi	zahedi	NOUN
bam-7218	1246	33	r	r	NOUN
bam-7218	1246	34	,	,	PUNCT
bam-7218	1246	35	217	217	NUM
bam-7218	1246	36	zampieri	zampieri	NOUN
bam-7218	1246	37	s	s	PART
bam-7218	1246	38	,	,	PUNCT
bam-7218	1246	39	222	222	NUM
bam-7218	1246	40	zanotti	zanotti	NOUN
bam-7218	1246	41	g	g	NOUN
bam-7218	1246	42	,	,	PUNCT
bam-7218	1246	43	203	203	NUM
bam-7218	1246	44	zecchini	zecchini	NUM
bam-7218	1246	45	s	s	PROPN
bam-7218	1246	46	,	,	PUNCT
bam-7218	1246	47	190	190	NUM
bam-7218	1246	48	zeynab	zeynab	NOUN
bam-7218	1246	49	k	k	NOUN
bam-7218	1246	50	,	,	PUNCT
bam-7218	1246	51	218	218	NUM
bam-7218	1246	52	zullo	zullo	PROPN
bam-7218	1246	53	l	l	NOUN
bam-7218	1246	54	,	,	PUNCT
bam-7218	1246	55	194	194	NUM