id sid tid token lemma pos bam-8931 1 1 muscle muscle NOUN bam-8931 1 2 impairment impairment NOUN bam-8931 1 3 in in ADP bam-8931 1 4 pre pre ADJ bam-8931 1 5 - - ADJ bam-8931 1 6 cachexia cachexia ADJ bam-8931 1 7 cancer cancer NOUN bam-8931 1 8 patients patient NOUN bam-8931 1 9 eur eur PROPN bam-8931 1 10 j j PROPN bam-8931 1 11 transl transl PROPN bam-8931 1 12 myol myol ADV bam-8931 1 13 30 30 NUM bam-8931 1 14 ( ( PUNCT bam-8931 1 15 2 2 NUM bam-8931 1 16 ): ): PUNCT bam-8931 1 17 258 258 NUM bam-8931 1 18 - - SYM bam-8931 1 19 267 267 NUM bam-8931 1 20 , , PUNCT bam-8931 1 21 2020 2020 NUM bam-8931 1 22 258 258 NUM bam-8931 1 23 muscle muscle NOUN bam-8931 1 24 function function NOUN bam-8931 1 25 impairment impairment NOUN bam-8931 1 26 in in ADP bam-8931 1 27 cancer cancer NOUN bam-8931 1 28 patients patient NOUN bam-8931 1 29 in in ADP bam-8931 1 30 pre pre ADJ bam-8931 1 31 - - ADJ bam-8931 1 32 cachexia cachexia ADJ bam-8931 1 33 stage stage NOUN bam-8931 1 34 stefania stefania NOUN bam-8931 1 35 dalise dalise NOUN bam-8931 1 36 ( ( PUNCT bam-8931 1 37 1 1 NUM bam-8931 1 38 ) ) PUNCT bam-8931 1 39 , , PUNCT bam-8931 1 40 peppino peppino PROPN bam-8931 1 41 tropea tropea PROPN bam-8931 1 42 ( ( PUNCT bam-8931 1 43 2 2 NUM bam-8931 1 44 ) ) PUNCT bam-8931 1 45 , , PUNCT bam-8931 1 46 luca luca PROPN bam-8931 1 47 galli galli NOUN bam-8931 1 48 ( ( PUNCT bam-8931 1 49 3 3 NUM bam-8931 1 50 ) ) PUNCT bam-8931 1 51 , , PUNCT bam-8931 1 52 andrea andrea PROPN bam-8931 1 53 sbrana sbrana PROPN bam-8931 1 54 ( ( PUNCT bam-8931 1 55 3 3 NUM bam-8931 1 56 ) ) PUNCT bam-8931 1 57 , , PUNCT bam-8931 1 58 carmelo carmelo NOUN bam-8931 1 59 chisari chisari NOUN bam-8931 1 60 ( ( PUNCT bam-8931 1 61 1 1 NUM bam-8931 1 62 ) ) PUNCT bam-8931 1 63 ( ( PUNCT bam-8931 1 64 1 1 X bam-8931 1 65 ) ) PUNCT bam-8931 1 66 unit unit NOUN bam-8931 1 67 of of ADP bam-8931 1 68 neurorehabilitation neurorehabilitation NOUN bam-8931 1 69 , , PUNCT bam-8931 1 70 university university NOUN bam-8931 1 71 hospital hospital NOUN bam-8931 1 72 of of ADP bam-8931 1 73 pisa pisa PROPN bam-8931 1 74 , , PUNCT bam-8931 1 75 pisa pisa PROPN bam-8931 1 76 , , PUNCT bam-8931 1 77 italy italy PROPN bam-8931 1 78 ; ; PUNCT bam-8931 1 79 ( ( PUNCT bam-8931 1 80 2 2 X bam-8931 1 81 ) ) PUNCT bam-8931 1 82 department department NOUN bam-8931 1 83 of of ADP bam-8931 1 84 neurorehabilitation neurorehabilitation PROPN bam-8931 1 85 sciences sciences PROPN bam-8931 1 86 casa casa PROPN bam-8931 1 87 cura cura PROPN bam-8931 1 88 policlinico policlinico PROPN bam-8931 1 89 , , PUNCT bam-8931 1 90 milan milan PROPN bam-8931 1 91 , , PUNCT bam-8931 1 92 italy italy PROPN bam-8931 1 93 ; ; PUNCT bam-8931 1 94 ( ( PUNCT bam-8931 1 95 3 3 X bam-8931 1 96 ) ) PUNCT bam-8931 1 97 unit unit NOUN bam-8931 1 98 of of ADP bam-8931 1 99 oncology oncology NOUN bam-8931 1 100 2 2 NUM bam-8931 1 101 , , PUNCT bam-8931 1 102 university university NOUN bam-8931 1 103 hospital hospital NOUN bam-8931 1 104 of of ADP bam-8931 1 105 pisa pisa PROPN bam-8931 1 106 , , PUNCT bam-8931 1 107 pisa pisa PROPN bam-8931 1 108 , , PUNCT bam-8931 1 109 italy italy PROPN bam-8931 1 110 . . PUNCT bam-8931 2 1 this this DET bam-8931 2 2 article article NOUN bam-8931 2 3 is be AUX bam-8931 2 4 distributed distribute VERB bam-8931 2 5 under under ADP bam-8931 2 6 the the DET bam-8931 2 7 terms term NOUN bam-8931 2 8 of of ADP bam-8931 2 9 the the DET bam-8931 2 10 creative creative ADJ bam-8931 2 11 commons common NOUN bam-8931 2 12 attribution attribution NOUN bam-8931 2 13 noncommercial noncommercial ADJ bam-8931 2 14 license license NOUN bam-8931 2 15 ( ( PUNCT bam-8931 2 16 cc cc NOUN bam-8931 2 17 by by ADP bam-8931 2 18 - - PUNCT bam-8931 2 19 nc nc PROPN bam-8931 2 20 4.0 4.0 NUM bam-8931 2 21 ) ) PUNCT bam-8931 2 22 which which PRON bam-8931 2 23 permits permit VERB bam-8931 2 24 any any DET bam-8931 2 25 noncommercial noncommercial ADJ bam-8931 2 26 use use NOUN bam-8931 2 27 , , PUNCT bam-8931 2 28 distribution distribution NOUN bam-8931 2 29 , , PUNCT bam-8931 2 30 and and CCONJ bam-8931 2 31 reproduction reproduction NOUN bam-8931 2 32 in in ADP bam-8931 2 33 any any DET bam-8931 2 34 medium medium NOUN bam-8931 2 35 , , PUNCT bam-8931 2 36 provided provide VERB bam-8931 2 37 the the DET bam-8931 2 38 original original ADJ bam-8931 2 39 author(s author(s NOUN bam-8931 2 40 ) ) PUNCT bam-8931 2 41 and and CCONJ bam-8931 2 42 source source NOUN bam-8931 2 43 are be AUX bam-8931 2 44 credited credit VERB bam-8931 2 45 . . PUNCT bam-8931 3 1 abstract abstract ADJ bam-8931 3 2 cancer cancer NOUN bam-8931 3 3 cachexia cachexia PROPN bam-8931 3 4 has have AUX bam-8931 3 5 been be AUX bam-8931 3 6 reported report VERB bam-8931 3 7 to to PART bam-8931 3 8 be be AUX bam-8931 3 9 directly directly ADV bam-8931 3 10 responsible responsible ADJ bam-8931 3 11 for for ADP bam-8931 3 12 at at ADV bam-8931 3 13 least least ADV bam-8931 3 14 20 20 NUM bam-8931 3 15 % % NOUN bam-8931 3 16 of of ADP bam-8931 3 17 cancer cancer NOUN bam-8931 3 18 deaths death NOUN bam-8931 3 19 . . PUNCT bam-8931 4 1 management management NOUN bam-8931 4 2 of of ADP bam-8931 4 3 muscle muscle NOUN bam-8931 4 4 wasting waste VERB bam-8931 4 5 in in ADP bam-8931 4 6 cancer cancer NOUN bam-8931 4 7 - - PUNCT bam-8931 4 8 associated associate VERB bam-8931 4 9 cachexia cachexia PROPN bam-8931 4 10 appears appear VERB bam-8931 4 11 to to PART bam-8931 4 12 be be AUX bam-8931 4 13 of of ADP bam-8931 4 14 pivotal pivotal ADJ bam-8931 4 15 importance importance NOUN bam-8931 4 16 for for ADP bam-8931 4 17 survival survival NOUN bam-8931 4 18 of of ADP bam-8931 4 19 patients patient NOUN bam-8931 4 20 . . PUNCT bam-8931 5 1 in in ADP bam-8931 5 2 this this DET bam-8931 5 3 regard regard NOUN bam-8931 5 4 , , PUNCT bam-8931 5 5 it it PRON bam-8931 5 6 would would AUX bam-8931 5 7 be be AUX bam-8931 5 8 interesting interesting ADJ bam-8931 5 9 to to PART bam-8931 5 10 identify identify VERB bam-8931 5 11 before before ADP bam-8931 5 12 its its PRON bam-8931 5 13 patent patent NOUN bam-8931 5 14 appearance appearance NOUN bam-8931 5 15 eventual eventual ADJ bam-8931 5 16 functional functional ADJ bam-8931 5 17 markers marker NOUN bam-8931 5 18 of of ADP bam-8931 5 19 muscle muscle NOUN bam-8931 5 20 damage damage NOUN bam-8931 5 21 , , PUNCT bam-8931 5 22 to to PART bam-8931 5 23 plan plan VERB bam-8931 5 24 specific specific ADJ bam-8931 5 25 exercise exercise NOUN bam-8931 5 26 protocols protocol NOUN bam-8931 5 27 to to PART bam-8931 5 28 counteract counteract VERB bam-8931 5 29 cachexia cachexia NOUN bam-8931 5 30 . . PUNCT bam-8931 6 1 the the DET bam-8931 6 2 muscle muscle NOUN bam-8931 6 3 function function NOUN bam-8931 6 4 of of ADP bam-8931 6 5 13 13 NUM bam-8931 6 6 oncologic oncologic ADJ bam-8931 6 7 patients patient NOUN bam-8931 6 8 and and CCONJ bam-8931 6 9 15 15 NUM bam-8931 6 10 controls control NOUN bam-8931 6 11 was be AUX bam-8931 6 12 analyzed analyze VERB bam-8931 6 13 through through ADP bam-8931 6 14 : : PUNCT bam-8931 6 15 i i NOUN bam-8931 6 16 ) ) PUNCT bam-8931 6 17 analysis analysis NOUN bam-8931 6 18 of of ADP bam-8931 6 19 the the DET bam-8931 6 20 oxidative oxidative ADJ bam-8931 6 21 metabolism metabolism NOUN bam-8931 6 22 , , PUNCT bam-8931 6 23 indirectly indirectly ADV bam-8931 6 24 evaluated evaluate VERB bam-8931 6 25 trough trough ADJ bam-8931 6 26 dosage dosage NOUN bam-8931 6 27 of of ADP bam-8931 6 28 blood blood NOUN bam-8931 6 29 lactate lactate NOUN bam-8931 6 30 levels level NOUN bam-8931 6 31 before before ADP bam-8931 6 32 and and CCONJ bam-8931 6 33 after after ADP bam-8931 6 34 a a DET bam-8931 6 35 submaximal submaximal ADJ bam-8931 6 36 incremental incremental ADJ bam-8931 6 37 exercise exercise NOUN bam-8931 6 38 on on ADP bam-8931 6 39 a a DET bam-8931 6 40 treadmill treadmill NOUN bam-8931 6 41 ; ; PUNCT bam-8931 6 42 ii ii X bam-8931 6 43 ) ) PUNCT bam-8931 6 44 analysis analysis NOUN bam-8931 6 45 of of ADP bam-8931 6 46 strength strength NOUN bam-8931 6 47 and and CCONJ bam-8931 6 48 , , PUNCT bam-8931 6 49 iii iii X bam-8931 6 50 ) ) PUNCT bam-8931 6 51 endurance endurance NOUN bam-8931 6 52 , , PUNCT bam-8931 6 53 in in ADP bam-8931 6 54 both both CCONJ bam-8931 6 55 lower low ADJ bam-8931 6 56 and and CCONJ bam-8931 6 57 upper upper ADJ bam-8931 6 58 limbs limb NOUN bam-8931 6 59 muscles muscle NOUN bam-8931 6 60 , , PUNCT bam-8931 6 61 employing employ VERB bam-8931 6 62 an an DET bam-8931 6 63 isokinetic isokinetic ADJ bam-8931 6 64 dynamometer dynamometer NOUN bam-8931 6 65 . . PUNCT bam-8931 7 1 statistical statistical ADJ bam-8931 7 2 analyses analysis NOUN bam-8931 7 3 were be AUX bam-8931 7 4 carried carry VERB bam-8931 7 5 out out ADP bam-8931 7 6 to to PART bam-8931 7 7 compare compare VERB bam-8931 7 8 the the DET bam-8931 7 9 muscle muscle NOUN bam-8931 7 10 activities activity NOUN bam-8931 7 11 between between ADP bam-8931 7 12 groups group NOUN bam-8931 7 13 . . PUNCT bam-8931 8 1 analysis analysis NOUN bam-8931 8 2 of of ADP bam-8931 8 3 oxidative oxidative ADJ bam-8931 8 4 metabolism metabolism NOUN bam-8931 8 5 during during ADP bam-8931 8 6 the the DET bam-8931 8 7 incremental incremental ADJ bam-8931 8 8 exercise exercise NOUN bam-8931 8 9 on on ADP bam-8931 8 10 a a DET bam-8931 8 11 treadmill treadmill NOUN bam-8931 8 12 showed show VERB bam-8931 8 13 that that SCONJ bam-8931 8 14 patients patient NOUN bam-8931 8 15 performed perform VERB bam-8931 8 16 a a DET bam-8931 8 17 shorter short ADJ bam-8931 8 18 exercise exercise NOUN bam-8931 8 19 than than ADP bam-8931 8 20 controls control NOUN bam-8931 8 21 . . PUNCT bam-8931 9 1 lactate lactate NOUN bam-8931 9 2 levels level NOUN bam-8931 9 3 were be AUX bam-8931 9 4 significantly significantly ADV bam-8931 9 5 higher high ADJ bam-8931 9 6 in in ADP bam-8931 9 7 patients patient NOUN bam-8931 9 8 both both CCONJ bam-8931 9 9 at at ADP bam-8931 9 10 baseline baseline NOUN bam-8931 9 11 and and CCONJ bam-8931 9 12 after after ADP bam-8931 9 13 the the DET bam-8931 9 14 task task NOUN bam-8931 9 15 . . PUNCT bam-8931 10 1 muscle muscle NOUN bam-8931 10 2 strength strength NOUN bam-8931 10 3 analysis analysis NOUN bam-8931 10 4 in in ADP bam-8931 10 5 patients patient NOUN bam-8931 10 6 group group NOUN bam-8931 10 7 showed show VERB bam-8931 10 8 a a DET bam-8931 10 9 reduction reduction NOUN bam-8931 10 10 of of ADP bam-8931 10 11 maximum maximum ADJ bam-8931 10 12 voluntary voluntary ADJ bam-8931 10 13 contraction contraction NOUN bam-8931 10 14 during during ADP bam-8931 10 15 the the DET bam-8931 10 16 isometric isometric ADJ bam-8931 10 17 contraction contraction NOUN bam-8931 10 18 and and CCONJ bam-8931 10 19 , , PUNCT bam-8931 10 20 a a DET bam-8931 10 21 tendency tendency NOUN bam-8931 10 22 to to ADP bam-8931 10 23 fatigue fatigue NOUN bam-8931 10 24 during during ADP bam-8931 10 25 endurance endurance NOUN bam-8931 10 26 task task NOUN bam-8931 10 27 . . PUNCT bam-8931 11 1 data datum NOUN bam-8931 11 2 emerging emerge VERB bam-8931 11 3 from from ADP bam-8931 11 4 this this DET bam-8931 11 5 study study NOUN bam-8931 11 6 highlight highlight VERB bam-8931 11 7 an an DET bam-8931 11 8 impairment impairment NOUN bam-8931 11 9 of of ADP bam-8931 11 10 muscle muscle NOUN bam-8931 11 11 oxidative oxidative ADJ bam-8931 11 12 metabolism metabolism NOUN bam-8931 11 13 in in ADP bam-8931 11 14 subjects subject NOUN bam-8931 11 15 affected affect VERB bam-8931 11 16 by by ADP bam-8931 11 17 a a DET bam-8931 11 18 pre pre ADJ bam-8931 11 19 - - ADJ bam-8931 11 20 cachexia cachexia ADJ bam-8931 11 21 stage stage NOUN bam-8931 11 22 of of ADP bam-8931 11 23 cancer cancer NOUN bam-8931 11 24 . . PUNCT bam-8931 12 1 a a DET bam-8931 12 2 trend trend NOUN bam-8931 12 3 of of ADP bam-8931 12 4 precocious precocious ADJ bam-8931 12 5 fatigability fatigability NOUN bam-8931 12 6 and and CCONJ bam-8931 12 7 an an DET bam-8931 12 8 impairment impairment NOUN bam-8931 12 9 of of ADP bam-8931 12 10 muscle muscle NOUN bam-8931 12 11 strength strength NOUN bam-8931 12 12 production production NOUN bam-8931 12 13 were be AUX bam-8931 12 14 also also ADV bam-8931 12 15 observed observe VERB bam-8931 12 16 . . PUNCT bam-8931 13 1 this this DET bam-8931 13 2 evidence evidence NOUN bam-8931 13 3 underlines underline VERB bam-8931 13 4 the the DET bam-8931 13 5 relevance relevance NOUN bam-8931 13 6 of of ADP bam-8931 13 7 assessing assess VERB bam-8931 13 8 muscle muscle NOUN bam-8931 13 9 function function NOUN bam-8931 13 10 in in ADP bam-8931 13 11 order order NOUN bam-8931 13 12 to to PART bam-8931 13 13 develop develop VERB bam-8931 13 14 novel novel ADJ bam-8931 13 15 rehabilitative rehabilitative ADJ bam-8931 13 16 approaches approach NOUN bam-8931 13 17 able able ADJ bam-8931 13 18 to to PART bam-8931 13 19 counteract counteract VERB bam-8931 13 20 motor motor NOUN bam-8931 13 21 impairment impairment NOUN bam-8931 13 22 and and CCONJ bam-8931 13 23 eventually eventually ADV bam-8931 13 24 to to PART bam-8931 13 25 prevent prevent VERB bam-8931 13 26 cachexia cachexia NOUN bam-8931 13 27 in in ADP bam-8931 13 28 these these DET bam-8931 13 29 patients patient NOUN bam-8931 13 30 . . PUNCT bam-8931 14 1 key key ADJ bam-8931 14 2 words word NOUN bam-8931 14 3 : : PUNCT bam-8931 14 4 cachexia cachexia NOUN bam-8931 14 5 , , PUNCT bam-8931 14 6 oxidative oxidative ADJ bam-8931 14 7 metabolism metabolism NOUN bam-8931 14 8 , , PUNCT bam-8931 14 9 cancer cancer NOUN bam-8931 14 10 , , PUNCT bam-8931 14 11 muscle muscle NOUN bam-8931 14 12 modifications modification NOUN bam-8931 14 13 , , PUNCT bam-8931 14 14 physical physical ADJ bam-8931 14 15 exercise exercise NOUN bam-8931 14 16 eur eur PROPN bam-8931 14 17 j j PROPN bam-8931 14 18 transl transl PROPN bam-8931 14 19 myol myol ADV bam-8931 14 20 30 30 NUM bam-8931 14 21 ( ( PUNCT bam-8931 14 22 2 2 NUM bam-8931 14 23 ): ): PUNCT bam-8931 14 24 258 258 NUM bam-8931 14 25 - - SYM bam-8931 14 26 267 267 NUM bam-8931 14 27 , , PUNCT bam-8931 14 28 2020 2020 NUM bam-8931 14 29 cachexia cachexia NOUN bam-8931 14 30 is be AUX bam-8931 14 31 one one NUM bam-8931 14 32 of of ADP bam-8931 14 33 the the DET bam-8931 14 34 most most ADV bam-8931 14 35 frequent frequent ADJ bam-8931 14 36 effects effect NOUN bam-8931 14 37 of of ADP bam-8931 14 38 malignancy malignancy NOUN bam-8931 14 39 , , PUNCT bam-8931 14 40 affecting affect VERB bam-8931 14 41 50 50 NUM bam-8931 14 42 % % NOUN bam-8931 14 43 of of ADP bam-8931 14 44 untreated untreated ADJ bam-8931 14 45 cancer cancer NOUN bam-8931 14 46 patients.1,2 patients.1,2 PROPN bam-8931 14 47 cancer cancer NOUN bam-8931 14 48 - - PUNCT bam-8931 14 49 associated associate VERB bam-8931 14 50 cachexia cachexia NOUN bam-8931 14 51 ( ( PUNCT bam-8931 14 52 cc cc NOUN bam-8931 14 53 ) ) PUNCT bam-8931 14 54 is be AUX bam-8931 14 55 a a DET bam-8931 14 56 metabolic metabolic NOUN bam-8931 14 57 syndrome syndrome NOUN bam-8931 14 58 characterized characterize VERB bam-8931 14 59 by by ADP bam-8931 14 60 loss loss NOUN bam-8931 14 61 of of ADP bam-8931 14 62 skeletal skeletal ADJ bam-8931 14 63 muscle muscle NOUN bam-8931 14 64 with with ADP bam-8931 14 65 or or CCONJ bam-8931 14 66 without without ADP bam-8931 14 67 loss loss NOUN bam-8931 14 68 of of ADP bam-8931 14 69 fat fat ADJ bam-8931 14 70 mass.3 mass.3 NOUN bam-8931 14 71 this this DET bam-8931 14 72 syndrome syndrome NOUN bam-8931 14 73 has have AUX bam-8931 14 74 been be AUX bam-8931 14 75 reported report VERB bam-8931 14 76 to to PART bam-8931 14 77 be be AUX bam-8931 14 78 directly directly ADV bam-8931 14 79 responsible responsible ADJ bam-8931 14 80 for for ADP bam-8931 14 81 at at ADV bam-8931 14 82 least least ADV bam-8931 14 83 20 20 NUM bam-8931 14 84 % % NOUN bam-8931 14 85 of of ADP bam-8931 14 86 cancer cancer NOUN bam-8931 14 87 deaths.4 deaths.4 PROPN bam-8931 14 88 decrease decrease NOUN bam-8931 14 89 in in ADP bam-8931 14 90 muscle muscle NOUN bam-8931 14 91 mass mass NOUN bam-8931 14 92 leads lead VERB bam-8931 14 93 to to ADP bam-8931 14 94 generalized generalized ADJ bam-8931 14 95 weakness weakness NOUN bam-8931 14 96 , , PUNCT bam-8931 14 97 decreased decrease VERB bam-8931 14 98 mobility mobility NOUN bam-8931 14 99 , , PUNCT bam-8931 14 100 and and CCONJ bam-8931 14 101 compromised compromise VERB bam-8931 14 102 quality quality NOUN bam-8931 14 103 of of ADP bam-8931 14 104 life life NOUN bam-8931 14 105 ( ( PUNCT bam-8931 14 106 qol qol NOUN bam-8931 14 107 ) ) PUNCT bam-8931 14 108 . . PUNCT bam-8931 15 1 despite despite SCONJ bam-8931 15 2 its its PRON bam-8931 15 3 association association NOUN bam-8931 15 4 with with ADP bam-8931 15 5 devastating devastating ADJ bam-8931 15 6 chronic chronic ADJ bam-8931 15 7 diseases disease NOUN bam-8931 15 8 , , PUNCT bam-8931 15 9 such such ADJ bam-8931 15 10 as as ADP bam-8931 15 11 cancer cancer NOUN bam-8931 15 12 , , PUNCT bam-8931 15 13 the the DET bam-8931 15 14 clinical clinical ADJ bam-8931 15 15 importance importance NOUN bam-8931 15 16 of of ADP bam-8931 15 17 cachexia cachexia PROPN bam-8931 15 18 has have AUX bam-8931 15 19 been be AUX bam-8931 15 20 neglected neglect VERB bam-8931 15 21 for for ADP bam-8931 15 22 decades decade NOUN bam-8931 15 23 . . PUNCT bam-8931 16 1 it it PRON bam-8931 16 2 is be AUX bam-8931 16 3 now now ADV bam-8931 16 4 established establish VERB bam-8931 16 5 that that SCONJ bam-8931 16 6 cachexia cachexia PROPN bam-8931 16 7 affects affect VERB bam-8931 16 8 prognosis prognosis NOUN bam-8931 16 9 , , PUNCT bam-8931 16 10 and and CCONJ bam-8931 16 11 reduces reduce VERB bam-8931 16 12 the the DET bam-8931 16 13 response response NOUN bam-8931 16 14 to to ADP bam-8931 16 15 therapy.1 therapy.1 PROPN bam-8931 16 16 recently recently ADV bam-8931 16 17 , , PUNCT bam-8931 16 18 it it PRON bam-8931 16 19 has have AUX bam-8931 16 20 emerged emerge VERB bam-8931 16 21 that that SCONJ bam-8931 16 22 skeletal skeletal ADJ bam-8931 16 23 muscle muscle NOUN bam-8931 16 24 mass mass NOUN bam-8931 16 25 is be AUX bam-8931 16 26 affected affect VERB bam-8931 16 27 not not PART bam-8931 16 28 only only ADV bam-8931 16 29 by by ADP bam-8931 16 30 disease disease NOUN bam-8931 16 31 progression progression NOUN bam-8931 16 32 but but CCONJ bam-8931 16 33 also also ADV bam-8931 16 34 by by ADP bam-8931 16 35 both both CCONJ bam-8931 16 36 therapeutic therapeutic ADJ bam-8931 16 37 and and CCONJ bam-8931 16 38 palliative palliative ADJ bam-8931 16 39 treatments treatment NOUN bam-8931 16 40 . . PUNCT bam-8931 17 1 it it PRON bam-8931 17 2 has have AUX bam-8931 17 3 been be AUX bam-8931 17 4 suggested suggest VERB bam-8931 17 5 that that SCONJ bam-8931 17 6 chemotherapy chemotherapy NOUN bam-8931 17 7 may may AUX bam-8931 17 8 be be AUX bam-8931 17 9 a a DET bam-8931 17 10 major major ADJ bam-8931 17 11 contributor contributor NOUN bam-8931 17 12 to to ADP bam-8931 17 13 the the DET bam-8931 17 14 development development NOUN bam-8931 17 15 and and CCONJ bam-8931 17 16 sustainment sustainment NOUN bam-8931 17 17 of of ADP bam-8931 17 18 cc.5 cc.5 PROPN bam-8931 17 19 the the DET bam-8931 17 20 newly newly ADV bam-8931 17 21 defined define VERB bam-8931 17 22 diagnostic diagnostic ADJ bam-8931 17 23 criteria criterion NOUN bam-8931 17 24 of of ADP bam-8931 17 25 cc cc PROPN bam-8931 17 26 will will AUX bam-8931 17 27 help help VERB bam-8931 17 28 diagnosis diagnosis NOUN bam-8931 17 29 and and CCONJ bam-8931 17 30 clinical clinical ADJ bam-8931 17 31 management management NOUN bam-8931 17 32 , , PUNCT bam-8931 17 33 as as ADV bam-8931 17 34 well well ADV bam-8931 17 35 as as ADP bam-8931 17 36 basic basic ADJ bam-8931 17 37 research.3 research.3 NOUN bam-8931 17 38 to to ADP bam-8931 17 39 date date NOUN bam-8931 17 40 , , PUNCT bam-8931 17 41 effective effective ADJ bam-8931 17 42 treatments treatment NOUN bam-8931 17 43 for for ADP bam-8931 17 44 cachexia cachexia NOUN bam-8931 17 45 are be AUX bam-8931 17 46 limited limited ADJ bam-8931 17 47 . . PUNCT bam-8931 18 1 ghrelin ghrelin NOUN bam-8931 18 2 agonists agonist NOUN bam-8931 18 3 , , PUNCT bam-8931 18 4 such such ADJ bam-8931 18 5 as as ADP bam-8931 18 6 anamorelin anamorelin PROPN bam-8931 18 7 , , PUNCT bam-8931 18 8 demonstrated demonstrate VERB bam-8931 18 9 efficacy efficacy NOUN bam-8931 18 10 in in ADP bam-8931 18 11 patients patient NOUN bam-8931 18 12 with with ADP bam-8931 18 13 metastatic metastatic ADJ bam-8931 18 14 non non ADJ bam-8931 18 15 - - ADJ bam-8931 18 16 small small ADJ bam-8931 18 17 cell cell NOUN bam-8931 18 18 lung lung NOUN bam-8931 18 19 cancer cancer NOUN bam-8931 18 20 and and CCONJ bam-8931 18 21 cachexia,6 cachexia,6 NOUN bam-8931 18 22 - - PUNCT bam-8931 18 23 7 7 NUM bam-8931 18 24 with with ADP bam-8931 18 25 limited limited ADJ bam-8931 18 26 and and CCONJ bam-8931 18 27 short short ADV bam-8931 18 28 - - PUNCT bam-8931 18 29 lasting last VERB bam-8931 18 30 efficacy efficacy NOUN bam-8931 18 31 . . PUNCT bam-8931 19 1 although although SCONJ bam-8931 19 2 molecular molecular ADJ bam-8931 19 3 mechanisms mechanism NOUN bam-8931 19 4 of of ADP bam-8931 19 5 cc cc NOUN bam-8931 19 6 remain remain VERB bam-8931 19 7 yet yet ADV bam-8931 19 8 to to PART bam-8931 19 9 be be AUX bam-8931 19 10 completely completely ADV bam-8931 19 11 defined define VERB bam-8931 19 12 , , PUNCT bam-8931 19 13 research research NOUN bam-8931 19 14 in in ADP bam-8931 19 15 the the DET bam-8931 19 16 last last ADJ bam-8931 19 17 two two NUM bam-8931 19 18 decades decade NOUN bam-8931 19 19 has have AUX bam-8931 19 20 made make VERB bam-8931 19 21 significant significant ADJ bam-8931 19 22 progress progress NOUN bam-8931 19 23 . . PUNCT bam-8931 20 1 firstly firstly ADV bam-8931 20 2 , , PUNCT bam-8931 20 3 several several ADJ bam-8931 20 4 mediators mediator NOUN bam-8931 20 5 have have AUX bam-8931 20 6 been be AUX bam-8931 20 7 identified identify VERB bam-8931 20 8 , , PUNCT bam-8931 20 9 including include VERB bam-8931 20 10 proinflammatory proinflammatory ADJ bam-8931 20 11 cytokines cytokine NOUN bam-8931 20 12 , , PUNCT bam-8931 20 13 such such ADJ bam-8931 20 14 as as ADP bam-8931 20 15 tumor tumor NOUN bam-8931 20 16 - - PUNCT bam-8931 20 17 necrosis necrosis NOUN bam-8931 20 18 factor factor NOUN bam-8931 20 19 alpha alpha NOUN bam-8931 20 20 ( ( PUNCT bam-8931 20 21 tnfα tnfα NOUN bam-8931 20 22 ) ) PUNCT bam-8931 20 23 , , PUNCT bam-8931 20 24 interferon interferon PROPN bam-8931 20 25 gamma gamma PROPN bam-8931 20 26 ( ( PUNCT bam-8931 20 27 ifnγ ifnγ NOUN bam-8931 20 28 ) ) PUNCT bam-8931 20 29 and and CCONJ bam-8931 20 30 interleukin-6 interleukin-6 NUM bam-8931 20 31 ( ( PUNCT bam-8931 20 32 il-6 il-6 NUM bam-8931 20 33 ) ) PUNCT bam-8931 20 34 , , PUNCT bam-8931 20 35 as as ADV bam-8931 20 36 well well ADV bam-8931 20 37 as as ADP bam-8931 20 38 tumorsecreted tumorsecrete VERB bam-8931 20 39 proteolysis proteolysis NOUN bam-8931 20 40 - - PUNCT bam-8931 20 41 inducing induce VERB bam-8931 20 42 factor factor NOUN bam-8931 20 43 ( ( PUNCT bam-8931 20 44 pif).1 pif).1 NOUN bam-8931 20 45 - - SYM bam-8931 20 46 8 8 NUM bam-8931 20 47 - - SYM bam-8931 20 48 9 9 NUM bam-8931 20 49 secondly secondly ADV bam-8931 20 50 , , PUNCT bam-8931 20 51 cachexia cachexia PROPN bam-8931 20 52 mediators mediator NOUN bam-8931 20 53 reduce reduce VERB bam-8931 20 54 lean lean ADJ bam-8931 20 55 muscle muscle NOUN bam-8931 20 56 mass mass NOUN bam-8931 20 57 by by ADP bam-8931 20 58 altering alter VERB bam-8931 20 59 homeostasis homeostasis NOUN bam-8931 20 60 between between ADP bam-8931 20 61 synthesis synthesis NOUN bam-8931 20 62 and and CCONJ bam-8931 20 63 degradation degradation NOUN bam-8931 20 64 of of ADP bam-8931 20 65 muscle muscle NOUN bam-8931 20 66 proteins.10 proteins.10 NOUN bam-8931 20 67 - - PUNCT bam-8931 20 68 12 12 NUM bam-8931 20 69 protein protein NOUN bam-8931 20 70 degradation degradation NOUN bam-8931 20 71 is be AUX bam-8931 20 72 largely largely ADV bam-8931 20 73 regulated regulate VERB bam-8931 20 74 by by ADP bam-8931 20 75 the the DET bam-8931 20 76 lysosomal lysosomal NOUN bam-8931 20 77 and and CCONJ bam-8931 20 78 ubiquitin ubiquitin ADJ bam-8931 20 79 - - PUNCT bam-8931 20 80 proteasome proteasome NOUN bam-8931 20 81 muscle muscle NOUN bam-8931 20 82 impairment impairment NOUN bam-8931 20 83 in in ADP bam-8931 20 84 pre pre ADJ bam-8931 20 85 - - ADJ bam-8931 20 86 cachexia cachexia ADJ bam-8931 20 87 cancer cancer NOUN bam-8931 20 88 patients patient NOUN bam-8931 20 89 eur eur PROPN bam-8931 20 90 j j PROPN bam-8931 20 91 transl transl PROPN bam-8931 20 92 myol myol ADV bam-8931 20 93 30 30 NUM bam-8931 20 94 ( ( PUNCT bam-8931 20 95 2 2 NUM bam-8931 20 96 ): ): PUNCT bam-8931 20 97 258 258 NUM bam-8931 20 98 - - SYM bam-8931 20 99 267 267 NUM bam-8931 20 100 , , PUNCT bam-8931 20 101 2020 2020 NUM bam-8931 20 102 259 259 NUM bam-8931 20 103 pathways.13 pathways.13 VERB bam-8931 20 104 - - PUNCT bam-8931 20 105 16 16 NUM bam-8931 20 106 genes gene NOUN bam-8931 20 107 regulating regulate VERB bam-8931 20 108 proteasome proteasome NOUN bam-8931 20 109 - - PUNCT bam-8931 20 110 mediated mediate VERB bam-8931 20 111 proteolysis proteolysis NOUN bam-8931 20 112 are be AUX bam-8931 20 113 elevated elevate VERB bam-8931 20 114 in in ADP bam-8931 20 115 cc cc NOUN bam-8931 20 116 animal animal NOUN bam-8931 20 117 models model NOUN bam-8931 20 118 as as ADV bam-8931 20 119 well well ADV bam-8931 20 120 as as ADP bam-8931 20 121 in in ADP bam-8931 20 122 patients.17 patients.17 ADJ bam-8931 20 123 - - PUNCT bam-8931 20 124 18 18 NUM bam-8931 20 125 identification identification NOUN bam-8931 20 126 of of ADP bam-8931 20 127 two two NUM bam-8931 20 128 muscle muscle NOUN bam-8931 20 129 - - PUNCT bam-8931 20 130 specific specific ADJ bam-8931 20 131 e3 e3 NOUN bam-8931 20 132 ubiquitin ubiquitin NOUN bam-8931 20 133 ligases ligase NOUN bam-8931 20 134 , , PUNCT bam-8931 20 135 muscle muscle NOUN bam-8931 20 136 ring ring NOUN bam-8931 20 137 - - PUNCT bam-8931 20 138 finger finger NOUN bam-8931 20 139 protein protein NOUN bam-8931 20 140 ( ( PUNCT bam-8931 20 141 murf1 murf1 ADJ bam-8931 20 142 ) ) PUNCT bam-8931 20 143 and and CCONJ bam-8931 20 144 atrogin-1 atrogin-1 NUM bam-8931 20 145 / / SYM bam-8931 20 146 muscle muscle NOUN bam-8931 20 147 atrophy atrophy NOUN bam-8931 20 148 f f PROPN bam-8931 20 149 - - PUNCT bam-8931 20 150 box box PROPN bam-8931 20 151 ( ( PUNCT bam-8931 20 152 mafbx mafbx PROPN bam-8931 20 153 ) ) PUNCT bam-8931 20 154 , , PUNCT bam-8931 20 155 have have AUX bam-8931 20 156 further far ADV bam-8931 20 157 demonstrated demonstrate VERB bam-8931 20 158 the the DET bam-8931 20 159 predominant predominant ADJ bam-8931 20 160 contribution contribution NOUN bam-8931 20 161 of of ADP bam-8931 20 162 the the DET bam-8931 20 163 proteasome proteasome NOUN bam-8931 20 164 pathway pathway NOUN bam-8931 20 165 in in ADP bam-8931 20 166 muscle muscle PROPN bam-8931 20 167 wasting.19 wasting.19 PROPN bam-8931 20 168 - - PUNCT bam-8931 20 169 20 20 NUM bam-8931 20 170 despite despite SCONJ bam-8931 20 171 these these DET bam-8931 20 172 insights insight NOUN bam-8931 20 173 into into ADP bam-8931 20 174 the the DET bam-8931 20 175 molecular molecular ADJ bam-8931 20 176 aetiology aetiology NOUN bam-8931 20 177 of of ADP bam-8931 20 178 cc cc PROPN bam-8931 20 179 , , PUNCT bam-8931 20 180 little little ADJ bam-8931 20 181 is be AUX bam-8931 20 182 known know VERB bam-8931 20 183 about about ADP bam-8931 20 184 muscle muscle NOUN bam-8931 20 185 wasting waste VERB bam-8931 20 186 impact impact NOUN bam-8931 20 187 on on ADP bam-8931 20 188 muscle muscle NOUN bam-8931 20 189 function function NOUN bam-8931 20 190 . . PUNCT bam-8931 21 1 significant significant ADJ bam-8931 21 2 loss loss NOUN bam-8931 21 3 of of ADP bam-8931 21 4 muscle muscle NOUN bam-8931 21 5 mass mass NOUN bam-8931 21 6 leads lead VERB bam-8931 21 7 to to ADP bam-8931 21 8 generalized generalized ADJ bam-8931 21 9 muscle muscle NOUN bam-8931 21 10 weakness weakness NOUN bam-8931 21 11 , , PUNCT bam-8931 21 12 however however ADV bam-8931 21 13 , , PUNCT bam-8931 21 14 little little ADJ bam-8931 21 15 is be AUX bam-8931 21 16 known know VERB bam-8931 21 17 about about ADP bam-8931 21 18 other other ADJ bam-8931 21 19 aspects aspect NOUN bam-8931 21 20 of of ADP bam-8931 21 21 muscle muscle NOUN bam-8931 21 22 function function NOUN bam-8931 21 23 , , PUNCT bam-8931 21 24 such such ADJ bam-8931 21 25 as as ADP bam-8931 21 26 force force NOUN bam-8931 21 27 - - PUNCT bam-8931 21 28 velocity velocity NOUN bam-8931 21 29 characteristics characteristic NOUN bam-8931 21 30 , , PUNCT bam-8931 21 31 power power NOUN bam-8931 21 32 output output NOUN bam-8931 21 33 , , PUNCT bam-8931 21 34 metabolic metabolic NOUN bam-8931 21 35 properties property NOUN bam-8931 21 36 , , PUNCT bam-8931 21 37 and and CCONJ bam-8931 21 38 fatigability fatigability NOUN bam-8931 21 39 . . PUNCT bam-8931 22 1 various various ADJ bam-8931 22 2 interventions intervention NOUN bam-8931 22 3 have have AUX bam-8931 22 4 been be AUX bam-8931 22 5 used use VERB bam-8931 22 6 to to PART bam-8931 22 7 counteract counteract VERB bam-8931 22 8 body body NOUN bam-8931 22 9 weight weight NOUN bam-8931 22 10 loss loss NOUN bam-8931 22 11 in in ADP bam-8931 22 12 cachexia cachexia NOUN bam-8931 22 13 , , PUNCT bam-8931 22 14 including include VERB bam-8931 22 15 aggressive aggressive ADJ bam-8931 22 16 nutritional nutritional ADJ bam-8931 22 17 support support NOUN bam-8931 22 18 and and CCONJ bam-8931 22 19 administration administration NOUN bam-8931 22 20 of of ADP bam-8931 22 21 appetite appetite ADJ bam-8931 22 22 stimulants stimulant NOUN bam-8931 22 23 . . PUNCT bam-8931 23 1 often often ADV bam-8931 23 2 , , PUNCT bam-8931 23 3 these these DET bam-8931 23 4 approaches approach NOUN bam-8931 23 5 , , PUNCT bam-8931 23 6 resulted result VERB bam-8931 23 7 in in ADP bam-8931 23 8 weight weight NOUN bam-8931 23 9 gain gain NOUN bam-8931 23 10 due due ADP bam-8931 23 11 to to ADP bam-8931 23 12 water water NOUN bam-8931 23 13 retention retention NOUN bam-8931 23 14 or or CCONJ bam-8931 23 15 fat fat ADJ bam-8931 23 16 gain gain NOUN bam-8931 23 17 , , PUNCT bam-8931 23 18 uncoupled uncoupled ADJ bam-8931 23 19 by by ADP bam-8931 23 20 functional functional ADJ bam-8931 23 21 body body NOUN bam-8931 23 22 lean lean ADJ bam-8931 23 23 mass mass ADJ bam-8931 23 24 gain.1 gain.1 NOUN bam-8931 23 25 contractile contractile NOUN bam-8931 23 26 activity activity NOUN bam-8931 23 27 is be AUX bam-8931 23 28 necessary necessary ADJ bam-8931 23 29 for for ADP bam-8931 23 30 postnatal postnatal ADJ bam-8931 23 31 muscle muscle NOUN bam-8931 23 32 growth growth NOUN bam-8931 23 33 and and CCONJ bam-8931 23 34 the the DET bam-8931 23 35 maintenance maintenance NOUN bam-8931 23 36 of of ADP bam-8931 23 37 muscle muscle NOUN bam-8931 23 38 mass mass NOUN bam-8931 23 39 in in ADP bam-8931 23 40 adults adult NOUN bam-8931 23 41 , , PUNCT bam-8931 23 42 and and CCONJ bam-8931 23 43 increased increase VERB bam-8931 23 44 work work NOUN bam-8931 23 45 can can AUX bam-8931 23 46 cause cause VERB bam-8931 23 47 fiber fiber NOUN bam-8931 23 48 hypertrophy.21 hypertrophy.21 NOUN bam-8931 23 49 conversely conversely ADV bam-8931 23 50 , , PUNCT bam-8931 23 51 disuse disuse NOUN bam-8931 23 52 or or CCONJ bam-8931 23 53 denervation denervation NOUN bam-8931 23 54 causes cause VERB bam-8931 23 55 rapid rapid ADJ bam-8931 23 56 atrophy.22 atrophy.22 NOUN bam-8931 23 57 it it PRON bam-8931 23 58 has have AUX bam-8931 23 59 been be AUX bam-8931 23 60 shown show VERB bam-8931 23 61 that that SCONJ bam-8931 23 62 muscle muscle NOUN bam-8931 23 63 contraction contraction NOUN bam-8931 23 64 performed perform VERB bam-8931 23 65 immediately immediately ADV bam-8931 23 66 after after SCONJ bam-8931 23 67 immobilization immobilization NOUN bam-8931 23 68 rapidly rapidly ADV bam-8931 23 69 instigates instigate VERB bam-8931 23 70 profound profound ADJ bam-8931 23 71 changes change NOUN bam-8931 23 72 in in ADP bam-8931 23 73 gene gene NOUN bam-8931 23 74 expression expression NOUN bam-8931 23 75 collectively collectively ADV bam-8931 23 76 linked link VERB bam-8931 23 77 to to ADP bam-8931 23 78 the the DET bam-8931 23 79 suppression suppression NOUN bam-8931 23 80 of of ADP bam-8931 23 81 muscle muscle NOUN bam-8931 23 82 catabolism catabolism NOUN bam-8931 23 83 and and CCONJ bam-8931 23 84 the the DET bam-8931 23 85 promotion promotion NOUN bam-8931 23 86 of of ADP bam-8931 23 87 muscle muscle NOUN bam-8931 23 88 hypertrophy hypertrophy NOUN bam-8931 23 89 and and CCONJ bam-8931 23 90 remodelling remodelling NOUN bam-8931 23 91 , , PUNCT bam-8931 23 92 with with ADP bam-8931 23 93 a a DET bam-8931 23 94 decline decline NOUN bam-8931 23 95 in in ADP bam-8931 23 96 mafbx mafbx NOUN bam-8931 23 97 and and CCONJ bam-8931 23 98 murf1 murf1 NOUN bam-8931 23 99 . . PUNCT bam-8931 24 1 in in ADP bam-8931 24 2 literature literature NOUN bam-8931 24 3 , , PUNCT bam-8931 24 4 several several ADJ bam-8931 24 5 studies study NOUN bam-8931 24 6 have have AUX bam-8931 24 7 investigated investigate VERB bam-8931 24 8 the the DET bam-8931 24 9 beneficial beneficial ADJ bam-8931 24 10 effects effect NOUN bam-8931 24 11 of of ADP bam-8931 24 12 physical physical ADJ bam-8931 24 13 exercise exercise NOUN bam-8931 24 14 in in ADP bam-8931 24 15 animal animal NOUN bam-8931 24 16 models model NOUN bam-8931 24 17 of of ADP bam-8931 24 18 cancer cancer NOUN bam-8931 24 19 . . PUNCT bam-8931 25 1 in in ADP bam-8931 25 2 a a DET bam-8931 25 3 recent recent ADJ bam-8931 25 4 study study NOUN bam-8931 25 5 , , PUNCT bam-8931 25 6 aulino aulino NOUN bam-8931 25 7 and and CCONJ bam-8931 25 8 colleagues,23 colleagues,23 NOUN bam-8931 25 9 observed observe VERB bam-8931 25 10 that that SCONJ bam-8931 25 11 physical physical ADJ bam-8931 25 12 activity activity NOUN bam-8931 25 13 diminishes diminish VERB bam-8931 25 14 total total ADJ bam-8931 25 15 body body NOUN bam-8931 25 16 weight weight NOUN bam-8931 25 17 loss loss NOUN bam-8931 25 18 of of ADP bam-8931 25 19 tumor tumor NOUN bam-8931 25 20 - - PUNCT bam-8931 25 21 bearing bear VERB bam-8931 25 22 mice mouse NOUN bam-8931 25 23 and and CCONJ bam-8931 25 24 increases increase VERB bam-8931 25 25 survival survival NOUN bam-8931 25 26 . . PUNCT bam-8931 26 1 authors author NOUN bam-8931 26 2 related relate VERB bam-8931 26 3 these these DET bam-8931 26 4 effects effect NOUN bam-8931 26 5 to to ADP bam-8931 26 6 significant significant ADJ bam-8931 26 7 changes change NOUN bam-8931 26 8 in in ADP bam-8931 26 9 levels level NOUN bam-8931 26 10 of of ADP bam-8931 26 11 hormones hormone NOUN bam-8931 26 12 namely namely ADV bam-8931 26 13 arginine arginine NOUN bam-8931 26 14 vasopressin vasopressin NOUN bam-8931 26 15 ( ( PUNCT bam-8931 26 16 avp avp PROPN bam-8931 26 17 ) ) PUNCT bam-8931 26 18 and and CCONJ bam-8931 26 19 ghrelins ghrelin NOUN bam-8931 26 20 ( ( PUNCT bam-8931 26 21 i.e. i.e. X bam-8931 26 22 , , PUNCT bam-8931 26 23 acyl acyl ADJ bam-8931 26 24 ghrelin ghrelin NOUN bam-8931 26 25 ( ( PUNCT bam-8931 26 26 aghr aghr ADJ bam-8931 26 27 ) ) PUNCT bam-8931 26 28 and and CCONJ bam-8931 26 29 des des ADJ bam-8931 26 30 - - ADJ bam-8931 26 31 acyl acyl ADJ bam-8931 26 32 ghrelin ghrelin NOUN bam-8931 26 33 ( ( PUNCT bam-8931 26 34 dghr dghr NOUN bam-8931 26 35 ) ) PUNCT bam-8931 26 36 that that PRON bam-8931 26 37 are be AUX bam-8931 26 38 known know VERB bam-8931 26 39 to to PART bam-8931 26 40 be be AUX bam-8931 26 41 potent potent ADJ bam-8931 26 42 pro pro ADJ bam-8931 26 43 - - ADJ bam-8931 26 44 myogenic myogenic ADJ bam-8931 26 45 and and CCONJ bam-8931 26 46 anti anti ADJ bam-8931 26 47 - - ADJ bam-8931 26 48 cachexia cachexia ADJ bam-8931 26 49 factors factor NOUN bam-8931 26 50 . . PUNCT bam-8931 27 1 recently recently ADV bam-8931 27 2 , , PUNCT bam-8931 27 3 two two NUM bam-8931 27 4 epidemiological epidemiological ADJ bam-8931 27 5 studies study NOUN bam-8931 27 6 and and CCONJ bam-8931 27 7 one one NUM bam-8931 27 8 clinical clinical ADJ bam-8931 27 9 trial trial NOUN bam-8931 27 10 showed show VERB bam-8931 27 11 that that SCONJ bam-8931 27 12 physical physical ADJ bam-8931 27 13 activity activity NOUN bam-8931 27 14 performed perform VERB bam-8931 27 15 post post ADJ bam-8931 27 16 - - NOUN bam-8931 27 17 diagnosis diagnosis NOUN bam-8931 27 18 , , PUNCT bam-8931 27 19 rather rather ADV bam-8931 27 20 than than ADP bam-8931 27 21 their their PRON bam-8931 27 22 exercise exercise NOUN bam-8931 27 23 habits habit NOUN bam-8931 27 24 before before SCONJ bam-8931 27 25 disease disease NOUN bam-8931 27 26 onset onset NOUN bam-8931 27 27 , , PUNCT bam-8931 27 28 improves improve VERB bam-8931 27 29 prognosis prognosis NOUN bam-8931 27 30 in in ADP bam-8931 27 31 cancer cancer NOUN bam-8931 27 32 patients.24 patients.24 NOUN bam-8931 27 33 - - PUNCT bam-8931 27 34 26 26 NUM bam-8931 27 35 these these DET bam-8931 27 36 studies study NOUN bam-8931 27 37 analyzed analyze VERB bam-8931 27 38 cohorts cohort NOUN bam-8931 27 39 of of ADP bam-8931 27 40 cancer cancer NOUN bam-8931 27 41 patients patient NOUN bam-8931 27 42 and and CCONJ bam-8931 27 43 concluded conclude VERB bam-8931 27 44 that that SCONJ bam-8931 27 45 physical physical ADJ bam-8931 27 46 activity activity NOUN bam-8931 27 47 after after SCONJ bam-8931 27 48 diagnosis diagnosis NOUN bam-8931 27 49 decreases decrease VERB bam-8931 27 50 the the DET bam-8931 27 51 risk risk NOUN bam-8931 27 52 of of ADP bam-8931 27 53 both both DET bam-8931 27 54 cancer cancer NOUN bam-8931 27 55 - - PUNCT bam-8931 27 56 specific specific ADJ bam-8931 27 57 and and CCONJ bam-8931 27 58 overall overall ADJ bam-8931 27 59 mortality.24 mortality.24 NOUN bam-8931 27 60 - - PUNCT bam-8931 27 61 26 26 NUM bam-8931 27 62 the the DET bam-8931 27 63 limits limit NOUN bam-8931 27 64 of of ADP bam-8931 27 65 these these DET bam-8931 27 66 observations observation NOUN bam-8931 27 67 are be AUX bam-8931 27 68 that that SCONJ bam-8931 27 69 the the DET bam-8931 27 70 studies study NOUN bam-8931 27 71 are be AUX bam-8931 27 72 observational observational ADJ bam-8931 27 73 in in ADP bam-8931 27 74 nature nature NOUN bam-8931 27 75 and and CCONJ bam-8931 27 76 cause cause VERB bam-8931 27 77 and and CCONJ bam-8931 27 78 effect effect NOUN bam-8931 27 79 can can AUX bam-8931 27 80 not not PART bam-8931 27 81 be be AUX bam-8931 27 82 assumed assume VERB bam-8931 27 83 . . PUNCT bam-8931 28 1 in in ADP bam-8931 28 2 this this DET bam-8931 28 3 regard regard NOUN bam-8931 28 4 , , PUNCT bam-8931 28 5 it it PRON bam-8931 28 6 would would AUX bam-8931 28 7 be be AUX bam-8931 28 8 interesting interesting ADJ bam-8931 28 9 to to PART bam-8931 28 10 identify identify VERB bam-8931 28 11 early early ADJ bam-8931 28 12 functional functional ADJ bam-8931 28 13 markers marker NOUN bam-8931 28 14 of of ADP bam-8931 28 15 muscle muscle NOUN bam-8931 28 16 damage damage NOUN bam-8931 28 17 in in ADP bam-8931 28 18 order order NOUN bam-8931 28 19 to to PART bam-8931 28 20 plan plan VERB bam-8931 28 21 specific specific ADJ bam-8931 28 22 exercise exercise NOUN bam-8931 28 23 protocols protocol NOUN bam-8931 28 24 to to PART bam-8931 28 25 counteract counteract VERB bam-8931 28 26 cc cc PROPN bam-8931 28 27 . . PROPN bam-8931 28 28 for for ADP bam-8931 28 29 this this DET bam-8931 28 30 purpose purpose NOUN bam-8931 28 31 in in ADP bam-8931 28 32 our our PRON bam-8931 28 33 study study NOUN bam-8931 28 34 , , PUNCT bam-8931 28 35 we we PRON bam-8931 28 36 have have AUX bam-8931 28 37 extensively extensively ADV bam-8931 28 38 analyzed analyze VERB bam-8931 28 39 muscle muscle NOUN bam-8931 28 40 function function NOUN bam-8931 28 41 in in ADP bam-8931 28 42 a a DET bam-8931 28 43 heterogeneous heterogeneous ADJ bam-8931 28 44 group group NOUN bam-8931 28 45 of of ADP bam-8931 28 46 cancer cancer NOUN bam-8931 28 47 patients patient NOUN bam-8931 28 48 at at ADP bam-8931 28 49 a a DET bam-8931 28 50 different different ADJ bam-8931 28 51 stage stage NOUN bam-8931 28 52 of of ADP bam-8931 28 53 the the DET bam-8931 28 54 disease disease NOUN bam-8931 28 55 . . PUNCT bam-8931 29 1 materials material NOUN bam-8931 29 2 and and CCONJ bam-8931 29 3 methods method NOUN bam-8931 29 4 the the DET bam-8931 29 5 patients patient NOUN bam-8931 29 6 involved involve VERB bam-8931 29 7 in in ADP bam-8931 29 8 the the DET bam-8931 29 9 study study NOUN bam-8931 29 10 were be AUX bam-8931 29 11 enrolled enrol VERB bam-8931 29 12 at at ADP bam-8931 29 13 the the DET bam-8931 29 14 department department NOUN bam-8931 29 15 of of ADP bam-8931 29 16 clinical clinical ADJ bam-8931 29 17 oncology oncology NOUN bam-8931 29 18 , , PUNCT bam-8931 29 19 university university NOUN bam-8931 29 20 of of ADP bam-8931 29 21 pisa pisa PROPN bam-8931 29 22 . . PUNCT bam-8931 30 1 all all DET bam-8931 30 2 patients patient NOUN bam-8931 30 3 with with ADP bam-8931 30 4 a a DET bam-8931 30 5 cancer cancer NOUN bam-8931 30 6 diagnosis diagnosis NOUN bam-8931 30 7 ( ( PUNCT bam-8931 30 8 of of ADP bam-8931 30 9 any any DET bam-8931 30 10 type type NOUN bam-8931 30 11 and and CCONJ bam-8931 30 12 any any DET bam-8931 30 13 stage stage NOUN bam-8931 30 14 ) ) PUNCT bam-8931 30 15 who who PRON bam-8931 30 16 were be AUX bam-8931 30 17 about about ADJ bam-8931 30 18 to to PART bam-8931 30 19 start start VERB bam-8931 30 20 chemotherapy chemotherapy NOUN bam-8931 30 21 for for ADP bam-8931 30 22 their their PRON bam-8931 30 23 disease disease NOUN bam-8931 30 24 were be AUX bam-8931 30 25 eligible eligible ADJ bam-8931 30 26 for for ADP bam-8931 30 27 the the DET bam-8931 30 28 inclusion inclusion NOUN bam-8931 30 29 in in ADP bam-8931 30 30 the the DET bam-8931 30 31 study study NOUN bam-8931 30 32 . . PUNCT bam-8931 31 1 all all DET bam-8931 31 2 participants participant NOUN bam-8931 31 3 to to ADP bam-8931 31 4 the the DET bam-8931 31 5 study study NOUN bam-8931 31 6 were be AUX bam-8931 31 7 evaluated evaluate VERB bam-8931 31 8 for for ADP bam-8931 31 9 the the DET bam-8931 31 10 presence presence NOUN bam-8931 31 11 of of ADP bam-8931 31 12 signs sign NOUN bam-8931 31 13 of of ADP bam-8931 31 14 symptoms symptom NOUN bam-8931 31 15 of of ADP bam-8931 31 16 pre pre NOUN bam-8931 31 17 - - ADJ bam-8931 31 18 cachexia cachexia ADJ bam-8931 31 19 or or CCONJ bam-8931 31 20 cachexia cachexia NOUN bam-8931 31 21 , , PUNCT bam-8931 31 22 according accord VERB bam-8931 31 23 to to ADP bam-8931 31 24 the the DET bam-8931 31 25 criteria criterion NOUN bam-8931 31 26 emerged emerge VERB bam-8931 31 27 from from ADP bam-8931 31 28 the the DET bam-8931 31 29 international international ADJ bam-8931 31 30 consensus consensus NOUN bam-8931 31 31 conference conference NOUN bam-8931 31 32 published publish VERB bam-8931 31 33 in in ADP bam-8931 31 34 2011,27 2011,27 NUM bam-8931 31 35 as as ADP bam-8931 31 36 the the DET bam-8931 31 37 major major ADJ bam-8931 31 38 exclusion exclusion NOUN bam-8931 31 39 criterion criterion NOUN bam-8931 31 40 . . PUNCT bam-8931 32 1 other other ADJ bam-8931 32 2 exclusion exclusion NOUN bam-8931 32 3 criteria criterion NOUN bam-8931 32 4 for for ADP bam-8931 32 5 both both DET bam-8931 32 6 groups group NOUN bam-8931 32 7 were be AUX bam-8931 32 8 : : PUNCT bam-8931 32 9 a a DET bam-8931 32 10 severe severe ADJ bam-8931 32 11 pulmonary pulmonary NOUN bam-8931 32 12 or or CCONJ bam-8931 32 13 cardiac cardiac ADJ bam-8931 32 14 failure failure NOUN bam-8931 32 15 , , PUNCT bam-8931 32 16 fever fever NOUN bam-8931 32 17 , , PUNCT bam-8931 32 18 neurologic neurologic ADJ bam-8931 32 19 / / SYM bam-8931 32 20 muscular muscular ADJ bam-8931 32 21 illnesses illness NOUN bam-8931 32 22 or or CCONJ bam-8931 32 23 a a DET bam-8931 32 24 physical physical ADJ bam-8931 32 25 inability inability NOUN bam-8931 32 26 to to PART bam-8931 32 27 exercise exercise VERB bam-8931 32 28 . . PUNCT bam-8931 33 1 no no DET bam-8931 33 2 limits limit NOUN bam-8931 33 3 on on ADP bam-8931 33 4 eligibility eligibility NOUN bam-8931 33 5 were be AUX bam-8931 33 6 based base VERB bam-8931 33 7 on on ADP bam-8931 33 8 the the DET bam-8931 33 9 sex sex NOUN bam-8931 33 10 of of ADP bam-8931 33 11 participants participant NOUN bam-8931 33 12 neither neither CCONJ bam-8931 33 13 on on ADP bam-8931 33 14 their their PRON bam-8931 33 15 age age NOUN bam-8931 33 16 . . PUNCT bam-8931 34 1 thirteen thirteen NUM bam-8931 34 2 patients patient NOUN bam-8931 34 3 affected affect VERB bam-8931 34 4 by by ADP bam-8931 34 5 solid solid ADJ bam-8931 34 6 tumors tumor NOUN bam-8931 34 7 were be AUX bam-8931 34 8 included include VERB bam-8931 34 9 in in ADP bam-8931 34 10 the the DET bam-8931 34 11 study study NOUN bam-8931 34 12 . . PUNCT bam-8931 35 1 the the DET bam-8931 35 2 patient patient ADJ bam-8931 35 3 group group NOUN bam-8931 35 4 was be AUX bam-8931 35 5 heterogeneous heterogeneous ADJ bam-8931 35 6 in in ADP bam-8931 35 7 terms term NOUN bam-8931 35 8 of of ADP bam-8931 35 9 demographic demographic ADJ bam-8931 35 10 and and CCONJ bam-8931 35 11 anthropometric anthropometric ADJ bam-8931 35 12 characteristics characteristic NOUN bam-8931 35 13 ( ( PUNCT bam-8931 35 14 e.g. e.g. ADV bam-8931 35 15 , , PUNCT bam-8931 35 16 age age NOUN bam-8931 35 17 , , PUNCT bam-8931 35 18 sex sex NOUN bam-8931 35 19 , , PUNCT bam-8931 35 20 weight weight NOUN bam-8931 35 21 , , PUNCT bam-8931 35 22 height height NOUN bam-8931 35 23 ) ) PUNCT bam-8931 35 24 , , PUNCT bam-8931 35 25 stage stage NOUN bam-8931 35 26 of of ADP bam-8931 35 27 the the DET bam-8931 35 28 disease disease NOUN bam-8931 35 29 and and CCONJ bam-8931 35 30 received receive VERB bam-8931 35 31 treatments treatment NOUN bam-8931 35 32 ( ( PUNCT bam-8931 35 33 e.g. e.g. ADV bam-8931 35 34 , , PUNCT bam-8931 35 35 surgery surgery NOUN bam-8931 35 36 , , PUNCT bam-8931 35 37 chemotherapy chemotherapy NOUN bam-8931 35 38 , , PUNCT bam-8931 35 39 or or CCONJ bam-8931 35 40 radiotherapy radiotherapy NOUN bam-8931 35 41 ) ) PUNCT bam-8931 35 42 . . PUNCT bam-8931 36 1 fifteen fifteen NUM bam-8931 36 2 healthy healthy ADJ bam-8931 36 3 subjects subject NOUN bam-8931 36 4 were be AUX bam-8931 36 5 recruited recruit VERB bam-8931 36 6 as as ADP bam-8931 36 7 a a DET bam-8931 36 8 control control NOUN bam-8931 36 9 group group NOUN bam-8931 36 10 , , PUNCT bam-8931 36 11 matched match VERB bam-8931 36 12 for for ADP bam-8931 36 13 demographic demographic ADJ bam-8931 36 14 and and CCONJ bam-8931 36 15 anthropometric anthropometric ADJ bam-8931 36 16 characteristics characteristic NOUN bam-8931 36 17 ( ( PUNCT bam-8931 36 18 i.e. i.e. X bam-8931 36 19 , , PUNCT bam-8931 36 20 age age NOUN bam-8931 36 21 , , PUNCT bam-8931 36 22 sex sex NOUN bam-8931 36 23 , , PUNCT bam-8931 36 24 weight weight NOUN bam-8931 36 25 , , PUNCT bam-8931 36 26 height height NOUN bam-8931 36 27 ) ) PUNCT bam-8931 36 28 to to ADP bam-8931 36 29 patients patient NOUN bam-8931 36 30 . . PUNCT bam-8931 37 1 after after ADP bam-8931 37 2 a a DET bam-8931 37 3 careful careful ADJ bam-8931 37 4 explanation explanation NOUN bam-8931 37 5 of of ADP bam-8931 37 6 procedures procedure NOUN bam-8931 37 7 , , PUNCT bam-8931 37 8 informed inform VERB bam-8931 37 9 consent consent NOUN bam-8931 37 10 was be AUX bam-8931 37 11 obtained obtain VERB bam-8931 37 12 from from ADP bam-8931 37 13 all all DET bam-8931 37 14 the the DET bam-8931 37 15 subjects subject NOUN bam-8931 37 16 . . PUNCT bam-8931 38 1 all all DET bam-8931 38 2 research research NOUN bam-8931 38 3 procedures procedure NOUN bam-8931 38 4 were be AUX bam-8931 38 5 in in ADP bam-8931 38 6 accordance accordance NOUN bam-8931 38 7 with with ADP bam-8931 38 8 the the DET bam-8931 38 9 declaration declaration NOUN bam-8931 38 10 of of ADP bam-8931 38 11 helsinki helsinki PROPN bam-8931 38 12 . . PUNCT bam-8931 39 1 the the DET bam-8931 39 2 study study NOUN bam-8931 39 3 was be AUX bam-8931 39 4 approved approve VERB bam-8931 39 5 by by ADP bam-8931 39 6 the the DET bam-8931 39 7 local local ADJ bam-8931 39 8 ethical ethical ADJ bam-8931 39 9 committee committee NOUN bam-8931 39 10 of of ADP bam-8931 39 11 university university PROPN bam-8931 39 12 hospital hospital NOUN bam-8931 39 13 of of ADP bam-8931 39 14 pisa pisa PROPN bam-8931 39 15 . . PUNCT bam-8931 40 1 all all DET bam-8931 40 2 the the DET bam-8931 40 3 evaluations evaluation NOUN bam-8931 40 4 described describe VERB bam-8931 40 5 below below ADV bam-8931 40 6 were be AUX bam-8931 40 7 performed perform VERB bam-8931 40 8 , , PUNCT bam-8931 40 9 for for ADP bam-8931 40 10 the the DET bam-8931 40 11 patient patient NOUN bam-8931 40 12 group group NOUN bam-8931 40 13 , , PUNCT bam-8931 40 14 the the DET bam-8931 40 15 very very ADV bam-8931 40 16 same same ADJ bam-8931 40 17 day day NOUN bam-8931 40 18 or or CCONJ bam-8931 40 19 , , PUNCT bam-8931 40 20 at at ADP bam-8931 40 21 most most ADJ bam-8931 40 22 , , PUNCT bam-8931 40 23 the the DET bam-8931 40 24 day day NOUN bam-8931 40 25 before before ADV bam-8931 40 26 , , PUNCT bam-8931 40 27 they they PRON bam-8931 40 28 started start VERB bam-8931 40 29 their their PRON bam-8931 40 30 chemotherapy chemotherapy NOUN bam-8931 40 31 . . PUNCT bam-8931 41 1 the the DET bam-8931 41 2 muscle muscle NOUN bam-8931 41 3 oxidative oxidative ADJ bam-8931 41 4 efficiency efficiency NOUN bam-8931 41 5 , , PUNCT bam-8931 41 6 the the DET bam-8931 41 7 maximum maximum ADJ bam-8931 41 8 voluntary voluntary ADJ bam-8931 41 9 strength strength NOUN bam-8931 41 10 of of ADP bam-8931 41 11 a a DET bam-8931 41 12 distal distal NOUN bam-8931 41 13 and and CCONJ bam-8931 41 14 a a DET bam-8931 41 15 proximal proximal ADJ bam-8931 41 16 district district NOUN bam-8931 41 17 and and CCONJ bam-8931 41 18 the the DET bam-8931 41 19 resistance resistance NOUN bam-8931 41 20 to to PART bam-8931 41 21 exercise exercise VERB bam-8931 41 22 were be AUX bam-8931 41 23 assessed assess VERB bam-8931 41 24 in in ADP bam-8931 41 25 both both DET bam-8931 41 26 groups group NOUN bam-8931 41 27 ( ( PUNCT bam-8931 41 28 i.e. i.e. X bam-8931 41 29 , , PUNCT bam-8931 41 30 patients patient NOUN bam-8931 41 31 and and CCONJ bam-8931 41 32 controls control NOUN bam-8931 41 33 ) ) PUNCT bam-8931 41 34 , , PUNCT bam-8931 41 35 and and CCONJ bam-8931 41 36 described describe VERB bam-8931 41 37 extensively extensively ADV bam-8931 41 38 in in ADP bam-8931 41 39 next next ADJ bam-8931 41 40 paragraphs paragraph NOUN bam-8931 41 41 . . PUNCT bam-8931 42 1 in in ADP bam-8931 42 2 addition addition NOUN bam-8931 42 3 , , PUNCT bam-8931 42 4 the the DET bam-8931 42 5 patients patient NOUN bam-8931 42 6 ’ ’ PART bam-8931 42 7 body body NOUN bam-8931 42 8 mass mass NOUN bam-8931 42 9 index index NOUN bam-8931 42 10 ( ( PUNCT bam-8931 42 11 bmi bmi PROPN bam-8931 42 12 ) ) PUNCT bam-8931 42 13 was be AUX bam-8931 42 14 evaluated evaluate VERB bam-8931 42 15 , , PUNCT bam-8931 42 16 and and CCONJ bam-8931 42 17 calculated calculate VERB bam-8931 42 18 according accord VERB bam-8931 42 19 to to ADP bam-8931 42 20 the the DET bam-8931 42 21 following follow VERB bam-8931 42 22 formula formula NOUN bam-8931 42 23 : : PUNCT bam-8931 42 24 where where SCONJ bam-8931 42 25 w w NOUN bam-8931 42 26 is be AUX bam-8931 42 27 the the DET bam-8931 42 28 weight weight NOUN bam-8931 42 29 of of ADP bam-8931 42 30 subjects subject NOUN bam-8931 42 31 express express VERB bam-8931 42 32 in in ADP bam-8931 42 33 kilograms kilogram NOUN bam-8931 42 34 ( ( PUNCT bam-8931 42 35 kg kg NOUN bam-8931 42 36 ) ) PUNCT bam-8931 42 37 and and CCONJ bam-8931 42 38 h h DET bam-8931 42 39 the the DET bam-8931 42 40 height height NOUN bam-8931 42 41 of of ADP bam-8931 42 42 subjects subject NOUN bam-8931 42 43 express express VERB bam-8931 42 44 in in ADP bam-8931 42 45 meters meter NOUN bam-8931 42 46 ( ( PUNCT bam-8931 42 47 m m NOUN bam-8931 42 48 ) ) PUNCT bam-8931 42 49 . . PUNCT bam-8931 43 1 muscle muscle NOUN bam-8931 43 2 oxidative oxidative ADJ bam-8931 43 3 efficiency efficiency NOUN bam-8931 43 4 evaluation evaluation NOUN bam-8931 43 5 muscle muscle NOUN bam-8931 43 6 oxidative oxidative ADJ bam-8931 43 7 efficiency efficiency NOUN bam-8931 43 8 was be AUX bam-8931 43 9 indirectly indirectly ADV bam-8931 43 10 evaluated evaluate VERB bam-8931 43 11 through through ADP bam-8931 43 12 the the DET bam-8931 43 13 determination determination NOUN bam-8931 43 14 of of ADP bam-8931 43 15 blood blood NOUN bam-8931 43 16 lactate lactate NOUN bam-8931 43 17 levels level NOUN bam-8931 43 18 before before ADP bam-8931 43 19 and and CCONJ bam-8931 43 20 after after ADP bam-8931 43 21 an an DET bam-8931 43 22 aerobic aerobic ADJ bam-8931 43 23 exercise exercise NOUN bam-8931 43 24 on on ADP bam-8931 43 25 a a DET bam-8931 43 26 treadmill treadmill NOUN bam-8931 43 27 : : PUNCT bam-8931 43 28 this this DET bam-8931 43 29 test test NOUN bam-8931 43 30 provides provide VERB bam-8931 43 31 an an DET bam-8931 43 32 estimation estimation NOUN bam-8931 43 33 of of ADP bam-8931 43 34 energetic energetic ADJ bam-8931 43 35 consumption consumption NOUN bam-8931 43 36 during during ADP bam-8931 43 37 the the DET bam-8931 43 38 motor motor NOUN bam-8931 43 39 task.28 task.28 PROPN bam-8931 43 40 - - PUNCT bam-8931 43 41 29 29 NUM bam-8931 43 42 the the DET bam-8931 43 43 exercising exercise VERB bam-8931 43 44 test test NOUN bam-8931 43 45 consisted consist VERB bam-8931 43 46 of of ADP bam-8931 43 47 an an DET bam-8931 43 48 incremental incremental ADJ bam-8931 43 49 submaximal submaximal ADJ bam-8931 43 50 exercise exercise NOUN bam-8931 43 51 on on ADP bam-8931 43 52 a a DET bam-8931 43 53 calibrated calibrate VERB bam-8931 43 54 electronically electronically ADV bam-8931 43 55 braked brake VERB bam-8931 43 56 treadmill treadmill NOUN bam-8931 43 57 . . PUNCT bam-8931 44 1 exercise exercise NOUN bam-8931 44 2 protocol protocol PROPN bam-8931 44 3 consists consist VERB bam-8931 44 4 of of ADP bam-8931 44 5 24 24 NUM bam-8931 44 6 minutes minute NOUN bam-8931 44 7 of of ADP bam-8931 44 8 walking walk VERB bam-8931 44 9 at at ADP bam-8931 44 10 a a DET bam-8931 44 11 constant constant ADJ bam-8931 44 12 speed speed NOUN bam-8931 44 13 of of ADP bam-8931 44 14 3 3 NUM bam-8931 44 15 km km NOUN bam-8931 44 16 / / SYM bam-8931 44 17 h h NOUN bam-8931 44 18 ; ; PUNCT bam-8931 44 19 the the DET bam-8931 44 20 first first ADJ bam-8931 44 21 and and CCONJ bam-8931 44 22 last last ADJ bam-8931 44 23 minutes minute NOUN bam-8931 44 24 were be AUX bam-8931 44 25 , , PUNCT bam-8931 44 26 respectively respectively ADV bam-8931 44 27 , , PUNCT bam-8931 44 28 warm warm ADJ bam-8931 44 29 - - PUNCT bam-8931 44 30 up up NOUN bam-8931 44 31 and and CCONJ bam-8931 44 32 cool cool ADJ bam-8931 44 33 - - PUNCT bam-8931 44 34 down down ADP bam-8931 44 35 periods period NOUN bam-8931 44 36 . . PUNCT bam-8931 45 1 during during ADP bam-8931 45 2 the the DET bam-8931 45 3 first first ADJ bam-8931 45 4 three three NUM bam-8931 45 5 minutes minute NOUN bam-8931 45 6 , , PUNCT bam-8931 45 7 the the DET bam-8931 45 8 inclination inclination NOUN bam-8931 45 9 of of ADP bam-8931 45 10 the the DET bam-8931 45 11 treadmill treadmill NOUN bam-8931 45 12 was be AUX bam-8931 45 13 0 0 NUM bam-8931 45 14 ° ° PRON bam-8931 45 15 then then ADV bam-8931 45 16 it it PRON bam-8931 45 17 increased increase VERB bam-8931 45 18 gradually gradually ADV bam-8931 45 19 of of ADP bam-8931 45 20 2.5 2.5 NUM bam-8931 45 21 % % NOUN bam-8931 45 22 slope slope NOUN bam-8931 45 23 every every DET bam-8931 45 24 two two NUM bam-8931 45 25 minutes minute NOUN bam-8931 45 26 . . PUNCT bam-8931 46 1 the the DET bam-8931 46 2 exercise exercise NOUN bam-8931 46 3 was be AUX bam-8931 46 4 early early ADV bam-8931 46 5 stopped stop VERB bam-8931 46 6 if if SCONJ bam-8931 46 7 the the DET bam-8931 46 8 patient patient NOUN bam-8931 46 9 reached reach VERB bam-8931 46 10 75 75 NUM bam-8931 46 11 % % NOUN bam-8931 46 12 of of ADP bam-8931 46 13 maximal maximal ADJ bam-8931 46 14 heart heart NOUN bam-8931 46 15 rate rate NOUN bam-8931 46 16 so so ADV bam-8931 46 17 keeping keep VERB bam-8931 46 18 the the DET bam-8931 46 19 exercise exercise NOUN bam-8931 46 20 predominantly predominantly ADV bam-8931 46 21 aerobic aerobic ADJ bam-8931 46 22 . . PUNCT bam-8931 47 1 the the DET bam-8931 47 2 maximal maximal ADJ bam-8931 47 3 heart heart NOUN bam-8931 47 4 rate rate NOUN bam-8931 47 5 ( ( PUNCT bam-8931 47 6 hrmax hrmax PROPN bam-8931 47 7 ) ) PUNCT bam-8931 47 8 was be AUX bam-8931 47 9 theoretically theoretically ADV bam-8931 47 10 calculated calculate VERB bam-8931 47 11 according accord VERB bam-8931 47 12 to to ADP bam-8931 47 13 the the DET bam-8931 47 14 formula formula NOUN bam-8931 47 15 : : PUNCT bam-8931 48 1 hrmax hrmax PROPN bam-8931 48 2 = = PROPN bam-8931 48 3 208 208 NUM bam-8931 48 4 – – PUNCT bam-8931 48 5 0.7x 0.7x NUM bam-8931 48 6 age.30 age.30 NOUN bam-8931 48 7 all all DET bam-8931 48 8 subjects subject NOUN bam-8931 48 9 were be AUX bam-8931 48 10 informed inform VERB bam-8931 48 11 that that SCONJ bam-8931 48 12 they they PRON bam-8931 48 13 could could AUX bam-8931 48 14 stop stop VERB bam-8931 48 15 exercise exercise NOUN bam-8931 48 16 at at ADP bam-8931 48 17 any any DET bam-8931 48 18 time time NOUN bam-8931 48 19 . . PUNCT bam-8931 49 1 lactate lactate PROPN bam-8931 49 2 was be AUX bam-8931 49 3 bmi bmi NOUN bam-8931 50 1 = = PUNCT bam-8931 50 2 w w PROPN bam-8931 50 3 h h NOUN bam-8931 50 4 2 2 NUM bam-8931 50 5 muscle muscle NOUN bam-8931 50 6 impairment impairment NOUN bam-8931 50 7 in in ADP bam-8931 50 8 pre pre ADJ bam-8931 50 9 - - ADJ bam-8931 50 10 cachexia cachexia ADJ bam-8931 50 11 cancer cancer NOUN bam-8931 50 12 patients patient NOUN bam-8931 50 13 eur eur PROPN bam-8931 50 14 j j PROPN bam-8931 50 15 transl transl PROPN bam-8931 50 16 myol myol ADV bam-8931 50 17 30 30 NUM bam-8931 50 18 ( ( PUNCT bam-8931 50 19 2 2 NUM bam-8931 50 20 ): ): PUNCT bam-8931 50 21 258 258 NUM bam-8931 50 22 - - SYM bam-8931 50 23 267 267 NUM bam-8931 50 24 , , PUNCT bam-8931 50 25 2020 2020 NUM bam-8931 50 26 260 260 NUM bam-8931 50 27 assessed assess VERB bam-8931 50 28 through through ADP bam-8931 50 29 venous venous ADJ bam-8931 50 30 blood blood NOUN bam-8931 50 31 samples sample NOUN bam-8931 50 32 , , PUNCT bam-8931 50 33 collected collect VERB bam-8931 50 34 before before ADV bam-8931 50 35 ( ( PUNCT bam-8931 50 36 t0 t0 NOUN bam-8931 50 37 ) ) PUNCT bam-8931 50 38 , , PUNCT bam-8931 50 39 immediately immediately ADV bam-8931 50 40 after after ADP bam-8931 50 41 ( ( PUNCT bam-8931 50 42 t1 t1 NOUN bam-8931 50 43 ) ) PUNCT bam-8931 50 44 and and CCONJ bam-8931 50 45 5 5 NUM bam-8931 50 46 , , PUNCT bam-8931 50 47 10 10 NUM bam-8931 50 48 and and CCONJ bam-8931 50 49 30 30 NUM bam-8931 50 50 minutes minute NOUN bam-8931 50 51 after after ADP bam-8931 50 52 the the DET bam-8931 50 53 end end NOUN bam-8931 50 54 of of ADP bam-8931 50 55 the the DET bam-8931 50 56 exercise exercise NOUN bam-8931 50 57 ( ( PUNCT bam-8931 50 58 respectively respectively ADV bam-8931 50 59 : : PUNCT bam-8931 50 60 t2 t2 NOUN bam-8931 50 61 , , PUNCT bam-8931 50 62 t3 t3 PROPN bam-8931 50 63 , , PUNCT bam-8931 50 64 t4 t4 PROPN bam-8931 50 65 ) ) PUNCT bam-8931 50 66 . . PUNCT bam-8931 51 1 blood blood NOUN bam-8931 51 2 sample sample NOUN bam-8931 51 3 was be AUX bam-8931 51 4 collected collect VERB bam-8931 51 5 in in ADP bam-8931 51 6 ethylenediaminetetraacetic ethylenediaminetetraacetic ADJ bam-8931 51 7 acid acid NOUN bam-8931 51 8 ( ( PUNCT bam-8931 51 9 edta edta NOUN bam-8931 51 10 ) ) PUNCT bam-8931 51 11 tubes tube NOUN bam-8931 51 12 . . PUNCT bam-8931 52 1 samples sample NOUN bam-8931 52 2 were be AUX bam-8931 52 3 withdrawn withdraw VERB bam-8931 52 4 by by ADP bam-8931 52 5 venipuncture venipuncture NOUN bam-8931 52 6 . . PUNCT bam-8931 53 1 lactate lactate PROPN bam-8931 53 2 was be AUX bam-8931 53 3 rapidly rapidly ADV bam-8931 53 4 analyzed analyze VERB bam-8931 53 5 through through ADP bam-8931 53 6 an an DET bam-8931 53 7 enzymatic enzymatic ADJ bam-8931 53 8 assay assay NOUN bam-8931 53 9 . . PUNCT bam-8931 54 1 muscle muscle NOUN bam-8931 54 2 strength strength NOUN bam-8931 54 3 evaluation evaluation NOUN bam-8931 54 4 muscle muscle NOUN bam-8931 54 5 strength strength NOUN bam-8931 54 6 was be AUX bam-8931 54 7 evaluated evaluate VERB bam-8931 54 8 measuring measure VERB bam-8931 54 9 maximum maximum ADJ bam-8931 54 10 voluntary voluntary ADJ bam-8931 54 11 contraction contraction NOUN bam-8931 54 12 ( ( PUNCT bam-8931 54 13 mvc mvc NOUN bam-8931 54 14 ) ) PUNCT bam-8931 54 15 in in ADP bam-8931 54 16 an an DET bam-8931 54 17 isometric isometric ADJ bam-8931 54 18 mode mode NOUN bam-8931 54 19 in in ADP bam-8931 54 20 both both CCONJ bam-8931 54 21 lower low ADJ bam-8931 54 22 ( ( PUNCT bam-8931 54 23 knee knee NOUN bam-8931 54 24 extension extension NOUN bam-8931 54 25 ) ) PUNCT bam-8931 54 26 and and CCONJ bam-8931 54 27 upper upper ADJ bam-8931 54 28 ( ( PUNCT bam-8931 54 29 handgrip handgrip NOUN bam-8931 54 30 ) ) PUNCT bam-8931 54 31 limbs limb NOUN bam-8931 54 32 . . PUNCT bam-8931 55 1 tests test NOUN bam-8931 55 2 were be AUX bam-8931 55 3 performed perform VERB bam-8931 55 4 on on ADP bam-8931 55 5 an an DET bam-8931 55 6 isokinetic isokinetic ADJ bam-8931 55 7 dynamometer dynamometer NOUN bam-8931 55 8 ( ( PUNCT bam-8931 55 9 primusrs primusrs X bam-8931 55 10 multi multi ADJ bam-8931 55 11 - - ADJ bam-8931 55 12 joint joint ADJ bam-8931 55 13 system system NOUN bam-8931 55 14 dynamometer dynamometer NOUN bam-8931 55 15 , , PUNCT bam-8931 55 16 bte bte NOUN bam-8931 55 17 technologies technology NOUN bam-8931 55 18 ) ) PUNCT bam-8931 55 19 . . PUNCT bam-8931 56 1 for for ADP bam-8931 56 2 evaluation evaluation NOUN bam-8931 56 3 of of ADP bam-8931 56 4 knee knee NOUN bam-8931 56 5 extension extension NOUN bam-8931 56 6 , , PUNCT bam-8931 56 7 patients patient NOUN bam-8931 56 8 sat sit VERB bam-8931 56 9 on on ADP bam-8931 56 10 a a DET bam-8931 56 11 chair chair NOUN bam-8931 56 12 with with SCONJ bam-8931 56 13 their their PRON bam-8931 56 14 upper upper ADJ bam-8931 56 15 body body NOUN bam-8931 56 16 strapped strap VERB bam-8931 56 17 firmly firmly ADV bam-8931 56 18 against against ADP bam-8931 56 19 the the DET bam-8931 56 20 backrest backrest NOUN bam-8931 56 21 of of ADP bam-8931 56 22 the the DET bam-8931 56 23 chair chair NOUN bam-8931 56 24 , , PUNCT bam-8931 56 25 straps strap NOUN bam-8931 56 26 tightened tighten VERB bam-8931 56 27 across across ADP bam-8931 56 28 their their PRON bam-8931 56 29 thighs thigh NOUN bam-8931 56 30 , , PUNCT bam-8931 56 31 arms arm NOUN bam-8931 56 32 were be AUX bam-8931 56 33 folded fold VERB bam-8931 56 34 . . PUNCT bam-8931 57 1 hip hip NOUN bam-8931 57 2 and and CCONJ bam-8931 57 3 knee knee NOUN bam-8931 57 4 angles angle NOUN bam-8931 57 5 were be AUX bam-8931 57 6 set set VERB bam-8931 57 7 respectively respectively ADV bam-8931 57 8 at at ADP bam-8931 57 9 110 110 NUM bam-8931 57 10 ° ° NOUN bam-8931 57 11 and and CCONJ bam-8931 57 12 at at ADP bam-8931 57 13 120 120 NUM bam-8931 57 14 ° ° NOUN bam-8931 57 15 ( ( PUNCT bam-8931 57 16 180 180 NUM bam-8931 57 17 ° ° NOUN bam-8931 57 18 refers refer VERB bam-8931 57 19 to to ADP bam-8931 57 20 full full ADJ bam-8931 57 21 extension extension NOUN bam-8931 57 22 ) ) PUNCT bam-8931 57 23 . . PUNCT bam-8931 58 1 for for ADP bam-8931 58 2 evaluation evaluation NOUN bam-8931 58 3 of of ADP bam-8931 58 4 handgrip handgrip NOUN bam-8931 58 5 , , PUNCT bam-8931 58 6 the the DET bam-8931 58 7 subject subject NOUN bam-8931 58 8 sat sit VERB bam-8931 58 9 on on ADP bam-8931 58 10 the the DET bam-8931 58 11 chair chair NOUN bam-8931 58 12 with with ADP bam-8931 58 13 their their PRON bam-8931 58 14 shoulders shoulder NOUN bam-8931 58 15 at at ADP bam-8931 58 16 0 0 NUM bam-8931 58 17 ° ° NOUN bam-8931 58 18 of of ADP bam-8931 58 19 abduction abduction NOUN bam-8931 58 20 and and CCONJ bam-8931 58 21 neutral neutral ADJ bam-8931 58 22 rotation rotation NOUN bam-8931 58 23 , , PUNCT bam-8931 58 24 elbows elbow VERB bam-8931 58 25 unsupported unsupported ADJ bam-8931 58 26 at at ADP bam-8931 58 27 90 90 NUM bam-8931 58 28 ° ° NOUN bam-8931 58 29 flexion flexion NOUN bam-8931 58 30 and and CCONJ bam-8931 58 31 forearms forearm NOUN bam-8931 58 32 in in ADP bam-8931 58 33 the the DET bam-8931 58 34 neutral neutral ADJ bam-8931 58 35 position position NOUN bam-8931 58 36 . . PUNCT bam-8931 59 1 before before ADP bam-8931 59 2 starting start VERB bam-8931 59 3 test test NOUN bam-8931 59 4 sections section NOUN bam-8931 59 5 , , PUNCT bam-8931 59 6 subjects subject NOUN bam-8931 59 7 were be AUX bam-8931 59 8 instructed instruct VERB bam-8931 59 9 about about ADP bam-8931 59 10 the the DET bam-8931 59 11 correct correct ADJ bam-8931 59 12 procedure procedure NOUN bam-8931 59 13 to to PART bam-8931 59 14 exert exert VERB bam-8931 59 15 maximum maximum ADJ bam-8931 59 16 voluntary voluntary ADJ bam-8931 59 17 contraction contraction NOUN bam-8931 59 18 , , PUNCT bam-8931 59 19 as as ADV bam-8931 59 20 hard hard ADV bam-8931 59 21 as as ADP bam-8931 59 22 possible possible ADJ bam-8931 59 23 without without ADP bam-8931 59 24 moving move VERB bam-8931 59 25 the the DET bam-8931 59 26 rest rest NOUN bam-8931 59 27 of of ADP bam-8931 59 28 the the DET bam-8931 59 29 body body NOUN bam-8931 59 30 , , PUNCT bam-8931 59 31 and and CCONJ bam-8931 59 32 to to PART bam-8931 59 33 maintain maintain VERB bam-8931 59 34 it it PRON bam-8931 59 35 for for ADP bam-8931 59 36 3 3 NUM bam-8931 59 37 s. s. PROPN bam-8931 59 38 each each DET bam-8931 59 39 subject subject NOUN bam-8931 59 40 performed perform VERB bam-8931 59 41 three three NUM bam-8931 59 42 consecutive consecutive ADJ bam-8931 59 43 repetitions repetition NOUN bam-8931 59 44 for for ADP bam-8931 59 45 each each DET bam-8931 59 46 limb limb NOUN bam-8931 59 47 and and CCONJ bam-8931 59 48 each each DET bam-8931 59 49 side side NOUN bam-8931 59 50 . . PUNCT bam-8931 60 1 a a DET bam-8931 60 2 rest rest NOUN bam-8931 60 3 time time NOUN bam-8931 60 4 ( ( PUNCT bam-8931 60 5 10 10 NUM bam-8931 60 6 s s NOUN bam-8931 60 7 ) ) PUNCT bam-8931 60 8 was be AUX bam-8931 60 9 observed observe VERB bam-8931 60 10 between between ADP bam-8931 60 11 consecutive consecutive ADJ bam-8931 60 12 trials trial NOUN bam-8931 60 13 . . PUNCT bam-8931 61 1 the the DET bam-8931 61 2 three three NUM bam-8931 61 3 tests test NOUN bam-8931 61 4 were be AUX bam-8931 61 5 accepted accept VERB bam-8931 61 6 when when SCONJ bam-8931 61 7 the the DET bam-8931 61 8 coefficient coefficient NOUN bam-8931 61 9 of of ADP bam-8931 61 10 variation variation NOUN bam-8931 61 11 ( ( PUNCT bam-8931 61 12 cv cv PROPN bam-8931 61 13 ) ) PUNCT bam-8931 61 14 was be AUX bam-8931 61 15 less less ADJ bam-8931 61 16 than than ADP bam-8931 61 17 10.0%.31 10.0%.31 ADJ bam-8931 61 18 muscle muscle NOUN bam-8931 61 19 fatigue fatigue NOUN bam-8931 61 20 and and CCONJ bam-8931 61 21 muscle muscle NOUN bam-8931 61 22 recovery recovery NOUN bam-8931 61 23 evaluations evaluation NOUN bam-8931 61 24 muscle muscle NOUN bam-8931 61 25 fatigue fatigue NOUN bam-8931 61 26 was be AUX bam-8931 61 27 evaluated evaluate VERB bam-8931 61 28 measuring measure VERB bam-8931 61 29 sustained sustained ADJ bam-8931 61 30 contractions contraction NOUN bam-8931 61 31 in in ADP bam-8931 61 32 isometric isometric ADJ bam-8931 61 33 tasks task NOUN bam-8931 61 34 , , PUNCT bam-8931 61 35 in in ADP bam-8931 61 36 both both CCONJ bam-8931 61 37 lower low ADJ bam-8931 61 38 ( ( PUNCT bam-8931 61 39 knee knee NOUN bam-8931 61 40 extension extension NOUN bam-8931 61 41 ) ) PUNCT bam-8931 61 42 and and CCONJ bam-8931 61 43 upper upper ADJ bam-8931 61 44 ( ( PUNCT bam-8931 61 45 handgrip handgrip NOUN bam-8931 61 46 ) ) PUNCT bam-8931 61 47 limbs limb NOUN bam-8931 61 48 . . PUNCT bam-8931 62 1 endurance endurance NOUN bam-8931 62 2 tests test NOUN bam-8931 62 3 were be AUX bam-8931 62 4 performed perform VERB bam-8931 62 5 on on ADP bam-8931 62 6 an an DET bam-8931 62 7 isokinetic isokinetic ADJ bam-8931 62 8 dynamometer dynamometer NOUN bam-8931 62 9 ( ( PUNCT bam-8931 62 10 see see VERB bam-8931 62 11 above above ADV bam-8931 62 12 for for ADP bam-8931 62 13 further further ADJ bam-8931 62 14 details detail NOUN bam-8931 62 15 ) ) PUNCT bam-8931 62 16 . . PUNCT bam-8931 63 1 subject subject ADJ bam-8931 63 2 , , PUNCT bam-8931 63 3 seated seat VERB bam-8931 63 4 as as SCONJ bam-8931 63 5 described describe VERB bam-8931 63 6 above above ADV bam-8931 63 7 , , PUNCT bam-8931 63 8 was be AUX bam-8931 63 9 instructed instruct VERB bam-8931 63 10 to to PART bam-8931 63 11 exert exert VERB bam-8931 63 12 mvc mvc NOUN bam-8931 63 13 for for ADP bam-8931 63 14 knee knee NOUN bam-8931 63 15 extension extension NOUN bam-8931 63 16 and and CCONJ bam-8931 63 17 for for ADP bam-8931 63 18 handgrip handgrip NOUN bam-8931 63 19 and and CCONJ bam-8931 63 20 to to PART bam-8931 63 21 maintain maintain VERB bam-8931 63 22 it it PRON bam-8931 63 23 for for ADP bam-8931 63 24 60 60 NUM bam-8931 63 25 s. s. NOUN bam-8931 63 26 both both DET bam-8931 63 27 sides side NOUN bam-8931 63 28 were be AUX bam-8931 63 29 evaluated evaluate VERB bam-8931 63 30 . . PUNCT bam-8931 64 1 each each DET bam-8931 64 2 subject subject NOUN bam-8931 64 3 was be AUX bam-8931 64 4 instructed instruct VERB bam-8931 64 5 about about ADP bam-8931 64 6 the the DET bam-8931 64 7 test test NOUN bam-8931 64 8 before before ADP bam-8931 64 9 starting start VERB bam-8931 64 10 and and CCONJ bam-8931 64 11 was be AUX bam-8931 64 12 not not PART bam-8931 64 13 further far ADV bam-8931 64 14 encouraged encourage VERB bam-8931 64 15 during during ADP bam-8931 64 16 the the DET bam-8931 64 17 performance performance NOUN bam-8931 64 18 . . PUNCT bam-8931 65 1 an an DET bam-8931 65 2 index index NOUN bam-8931 65 3 of of ADP bam-8931 65 4 muscle muscle NOUN bam-8931 65 5 fatigue fatigue NOUN bam-8931 65 6 was be AUX bam-8931 65 7 extracted extract VERB bam-8931 65 8 as as ADP bam-8931 65 9 the the DET bam-8931 65 10 slope slope NOUN bam-8931 65 11 of of ADP bam-8931 65 12 the the DET bam-8931 65 13 linear linear ADJ bam-8931 65 14 regression regression NOUN bam-8931 65 15 of of ADP bam-8931 65 16 contraction contraction NOUN bam-8931 65 17 trend trend NOUN bam-8931 65 18 . . PUNCT bam-8931 66 1 to to PART bam-8931 66 2 compare compare VERB bam-8931 66 3 them they PRON bam-8931 66 4 , , PUNCT bam-8931 66 5 the the DET bam-8931 66 6 endurance endurance NOUN bam-8931 66 7 index index NOUN bam-8931 66 8 was be AUX bam-8931 66 9 normalized normalize VERB bam-8931 66 10 for for ADP bam-8931 66 11 the the DET bam-8931 66 12 mvc mvc NOUN bam-8931 66 13 . . PUNCT bam-8931 67 1 to to PART bam-8931 67 2 evaluate evaluate VERB bam-8931 67 3 an an DET bam-8931 67 4 additional additional ADJ bam-8931 67 5 parameter parameter NOUN bam-8931 67 6 , , PUNCT bam-8931 67 7 the the DET bam-8931 67 8 muscle muscle NOUN bam-8931 67 9 recovery recovery NOUN bam-8931 67 10 , , PUNCT bam-8931 67 11 the the DET bam-8931 67 12 mvc mvc NOUN bam-8931 67 13 in in ADP bam-8931 67 14 isometric isometric ADJ bam-8931 67 15 mode mode NOUN bam-8931 67 16 ( ( PUNCT bam-8931 67 17 with with ADP bam-8931 67 18 3 3 NUM bam-8931 67 19 s s NOUN bam-8931 67 20 hold hold NOUN bam-8931 67 21 time time NOUN bam-8931 67 22 ) ) PUNCT bam-8931 67 23 was be AUX bam-8931 67 24 performed perform VERB bam-8931 67 25 after after ADP bam-8931 67 26 20 20 NUM bam-8931 67 27 s s NOUN bam-8931 67 28 of of ADP bam-8931 67 29 rest rest NOUN bam-8931 67 30 at at ADP bam-8931 67 31 the the DET bam-8931 67 32 end end NOUN bam-8931 67 33 of of ADP bam-8931 67 34 muscle muscle NOUN bam-8931 67 35 fatigue fatigue NOUN bam-8931 67 36 trial trial NOUN bam-8931 67 37 . . PUNCT bam-8931 68 1 to to PART bam-8931 68 2 obtain obtain VERB bam-8931 68 3 a a DET bam-8931 68 4 single single ADJ bam-8931 68 5 explicative explicative ADJ bam-8931 68 6 parameter parameter NOUN bam-8931 68 7 the the DET bam-8931 68 8 difference difference NOUN bam-8931 68 9 ( ( PUNCT bam-8931 68 10 ∆ ∆ X bam-8931 68 11 ) ) PUNCT bam-8931 68 12 between between ADP bam-8931 68 13 mvc mvc NOUN bam-8931 68 14 in in ADP bam-8931 68 15 muscle muscle NOUN bam-8931 68 16 recovery recovery NOUN bam-8931 68 17 time time NOUN bam-8931 68 18 and and CCONJ bam-8931 68 19 the the DET bam-8931 68 20 strength strength NOUN bam-8931 68 21 exerted exert VERB bam-8931 68 22 in in ADP bam-8931 68 23 the the DET bam-8931 68 24 last last ADJ bam-8931 68 25 3 3 NUM bam-8931 68 26 s s NOUN bam-8931 68 27 of of ADP bam-8931 68 28 muscle muscle NOUN bam-8931 68 29 fatigue fatigue NOUN bam-8931 68 30 task task NOUN bam-8931 68 31 was be AUX bam-8931 68 32 calculated calculate VERB bam-8931 68 33 . . PUNCT bam-8931 69 1 statistical statistical ADJ bam-8931 69 2 analysis analysis NOUN bam-8931 69 3 data datum NOUN bam-8931 69 4 are be AUX bam-8931 69 5 presented present VERB bam-8931 69 6 as as ADP bam-8931 69 7 mean mean ADJ bam-8931 69 8 with with ADP bam-8931 69 9 standard standard ADJ bam-8931 69 10 deviation deviation NOUN bam-8931 69 11 . . PUNCT bam-8931 70 1 the the DET bam-8931 70 2 significance significance NOUN bam-8931 70 3 of of ADP bam-8931 70 4 statistical statistical ADJ bam-8931 70 5 tests test NOUN bam-8931 70 6 was be AUX bam-8931 70 7 set set VERB bam-8931 70 8 at at ADP bam-8931 70 9 α=0.05 α=0.05 NOUN bam-8931 70 10 . . PUNCT bam-8931 71 1 distributions distribution NOUN bam-8931 71 2 were be AUX bam-8931 71 3 checked check VERB bam-8931 71 4 for for ADP bam-8931 71 5 normality normality NOUN bam-8931 71 6 with with ADP bam-8931 71 7 a a DET bam-8931 71 8 onesample onesample NOUN bam-8931 71 9 kolmogorov kolmogorov ADJ bam-8931 71 10 - - PUNCT bam-8931 71 11 smirnov smirnov ADJ bam-8931 71 12 test test NOUN bam-8931 71 13 . . PUNCT bam-8931 72 1 the the DET bam-8931 72 2 homoscedasticity homoscedasticity NOUN bam-8931 72 3 of of ADP bam-8931 72 4 residuals residual NOUN bam-8931 72 5 was be AUX bam-8931 72 6 tested test VERB bam-8931 72 7 with with ADP bam-8931 72 8 levene levene NOUN bam-8931 72 9 ’s ’s PART bam-8931 72 10 test test NOUN bam-8931 72 11 . . PUNCT bam-8931 73 1 the the DET bam-8931 73 2 normality normality NOUN bam-8931 73 3 test test NOUN bam-8931 73 4 showed show VERB bam-8931 73 5 that that SCONJ bam-8931 73 6 data datum NOUN bam-8931 73 7 did do AUX bam-8931 73 8 not not PART bam-8931 73 9 fit fit VERB bam-8931 73 10 the the DET bam-8931 73 11 normality normality NOUN bam-8931 73 12 distribution distribution NOUN bam-8931 73 13 ( ( PUNCT bam-8931 73 14 p<0.05 p<0.05 NOUN bam-8931 73 15 ) ) PUNCT bam-8931 73 16 and and CCONJ bam-8931 73 17 levene levene NOUN bam-8931 73 18 's 's PART bam-8931 73 19 test test NOUN bam-8931 73 20 showed show VERB bam-8931 73 21 that that SCONJ bam-8931 73 22 all all DET bam-8931 73 23 homologous homologous ADJ bam-8931 73 24 datasets dataset NOUN bam-8931 73 25 were be AUX bam-8931 73 26 characterized characterize VERB bam-8931 73 27 by by ADP bam-8931 73 28 equal equal ADJ bam-8931 73 29 variance variance NOUN bam-8931 73 30 . . PUNCT bam-8931 74 1 since since SCONJ bam-8931 74 2 the the DET bam-8931 74 3 analysis analysis NOUN bam-8931 74 4 of of ADP bam-8931 74 5 variance variance NOUN bam-8931 74 6 ( ( PUNCT bam-8931 74 7 anova anova PROPN bam-8931 74 8 ) ) PUNCT bam-8931 74 9 is be AUX bam-8931 74 10 relatively relatively ADV bam-8931 74 11 robust robust ADJ bam-8931 74 12 for for ADP bam-8931 74 13 violations violation NOUN bam-8931 74 14 of of ADP bam-8931 74 15 the the DET bam-8931 74 16 normality normality NOUN bam-8931 74 17 assumption assumption NOUN bam-8931 74 18 and and CCONJ bam-8931 74 19 more more ADV bam-8931 74 20 sensitive sensitive ADJ bam-8931 74 21 to to ADP bam-8931 74 22 heterogeneous heterogeneous ADJ bam-8931 74 23 variances,32 variances,32 NOUN bam-8931 74 24 the the DET bam-8931 74 25 preliminary preliminary ADJ bam-8931 74 26 analysis analysis NOUN bam-8931 74 27 of of ADP bam-8931 74 28 the the DET bam-8931 74 29 data data NOUN bam-8931 74 30 samples sample NOUN bam-8931 74 31 allowed allow VERB bam-8931 74 32 the the DET bam-8931 74 33 authors author NOUN bam-8931 74 34 to to PART bam-8931 74 35 confidently confidently ADV bam-8931 74 36 use use VERB bam-8931 74 37 the the DET bam-8931 74 38 anova anova PROPN bam-8931 74 39 as as ADP bam-8931 74 40 the the DET bam-8931 74 41 main main ADJ bam-8931 74 42 statistical statistical ADJ bam-8931 74 43 test test NOUN bam-8931 74 44 in in ADP bam-8931 74 45 this this DET bam-8931 74 46 study study NOUN bam-8931 74 47 . . PUNCT bam-8931 75 1 due due ADP bam-8931 75 2 to to ADP bam-8931 75 3 non non ADJ bam-8931 75 4 - - NOUN bam-8931 75 5 normality normality NOUN bam-8931 75 6 of of ADP bam-8931 75 7 the the DET bam-8931 75 8 dataset dataset NOUN bam-8931 75 9 , , PUNCT bam-8931 75 10 wilcoxon wilcoxon PROPN bam-8931 75 11 test test NOUN bam-8931 75 12 was be AUX bam-8931 75 13 used use VERB bam-8931 75 14 to to PART bam-8931 75 15 compare compare VERB bam-8931 75 16 walking walking NOUN bam-8931 75 17 time time NOUN bam-8931 75 18 on on ADP bam-8931 75 19 the the DET bam-8931 75 20 treadmill treadmill NOUN bam-8931 75 21 ( ( PUNCT bam-8931 75 22 i.e. i.e. X bam-8931 75 23 , , PUNCT bam-8931 75 24 duration duration NOUN bam-8931 75 25 ) ) PUNCT bam-8931 75 26 , , PUNCT bam-8931 75 27 and and CCONJ bam-8931 75 28 both both DET bam-8931 75 29 muscle muscle NOUN bam-8931 75 30 strength strength NOUN bam-8931 75 31 ( ( PUNCT bam-8931 75 32 i.e. i.e. X bam-8931 75 33 , , PUNCT bam-8931 75 34 mvc mvc NOUN bam-8931 75 35 in in ADP bam-8931 75 36 isometric isometric ADJ bam-8931 75 37 mode mode NOUN bam-8931 75 38 ) ) PUNCT bam-8931 75 39 , , PUNCT bam-8931 75 40 fatigue fatigue NOUN bam-8931 75 41 parameters parameter NOUN bam-8931 75 42 ( ( PUNCT bam-8931 75 43 i.e. i.e. X bam-8931 75 44 , , PUNCT bam-8931 75 45 slope slope NOUN bam-8931 75 46 and and CCONJ bam-8931 75 47 muscle muscle NOUN bam-8931 75 48 recovery recovery NOUN bam-8931 75 49 after after ADP bam-8931 75 50 20 20 NUM bam-8931 75 51 s s NOUN bam-8931 75 52 of of ADP bam-8931 75 53 resting rest VERB bam-8931 75 54 time time NOUN bam-8931 75 55 ( ( PUNCT bam-8931 75 56 i.e. i.e. X bam-8931 75 57 , , PUNCT bam-8931 75 58 ∆ ∆ NUM bam-8931 75 59 ) ) PUNCT bam-8931 75 60 ) ) PUNCT bam-8931 75 61 in in ADP bam-8931 75 62 patients patient NOUN bam-8931 75 63 and and CCONJ bam-8931 75 64 control control NOUN bam-8931 75 65 group group NOUN bam-8931 75 66 , , PUNCT bam-8931 75 67 for for ADP bam-8931 75 68 knee knee NOUN bam-8931 75 69 extension extension NOUN bam-8931 75 70 value value NOUN bam-8931 75 71 and and CCONJ bam-8931 75 72 handgrip handgrip NOUN bam-8931 75 73 measurements measurement NOUN bam-8931 75 74 . . PUNCT bam-8931 76 1 in in ADP bam-8931 76 2 the the DET bam-8931 76 3 analysis analysis NOUN bam-8931 76 4 of of ADP bam-8931 76 5 muscle muscle NOUN bam-8931 76 6 table table NOUN bam-8931 76 7 1 1 NUM bam-8931 76 8 demographic demographic ADJ bam-8931 76 9 and and CCONJ bam-8931 76 10 anthropometrics anthropometric NOUN bam-8931 76 11 of of ADP bam-8931 76 12 cancer cancer NOUN bam-8931 76 13 patients patient NOUN bam-8931 76 14 participants participant NOUN bam-8931 76 15 . . PUNCT bam-8931 77 1 i i PRON bam-8931 77 2 d d PROPN bam-8931 77 3 age age NOUN bam-8931 77 4 ( ( PUNCT bam-8931 77 5 yr yr NOUN bam-8931 77 6 ) ) PUNCT bam-8931 77 7 sex sex NOUN bam-8931 77 8 weight weight NOUN bam-8931 77 9 ( ( PUNCT bam-8931 77 10 kg kg NOUN bam-8931 77 11 ) ) PUNCT bam-8931 77 12 height height NOUN bam-8931 77 13 ( ( PUNCT bam-8931 77 14 cm cm NOUN bam-8931 77 15 ) ) PUNCT bam-8931 77 16 bmi bmi NOUN bam-8931 77 17 ( ( PUNCT bam-8931 77 18 kg kg NOUN bam-8931 77 19 / / SYM bam-8931 77 20 m2 m2 PROPN bam-8931 77 21 ) ) PUNCT bam-8931 77 22 level level NOUN bam-8931 77 23 of of ADP bam-8931 77 24 physical physical ADJ bam-8931 77 25 exercises exercise NOUN bam-8931 77 26 p01 p01 VERB bam-8931 77 27 35 35 NUM bam-8931 77 28 m m NOUN bam-8931 77 29 107 107 NUM bam-8931 77 30 190 190 NUM bam-8931 77 31 29.6 29.6 NUM bam-8931 77 32 professional professional ADJ bam-8931 77 33 basket basket NOUN bam-8931 77 34 player player NOUN bam-8931 77 35 p02 p02 X bam-8931 77 36 54 54 NUM bam-8931 77 37 m m NUM bam-8931 77 38 66 66 NUM bam-8931 77 39 175 175 NUM bam-8931 77 40 21.6 21.6 NUM bam-8931 77 41 mildly mildly ADV bam-8931 77 42 active active ADJ bam-8931 77 43 p03 p03 NOUN bam-8931 77 44 69 69 NUM bam-8931 77 45 m m NOUN bam-8931 77 46 83 83 NUM bam-8931 77 47 167 167 NUM bam-8931 77 48 29.8 29.8 NUM bam-8931 77 49 sedentary sedentary ADJ bam-8931 77 50 p04 p04 PROPN bam-8931 77 51 31 31 NUM bam-8931 77 52 m m NOUN bam-8931 77 53 82 82 NUM bam-8931 77 54 183 183 NUM bam-8931 77 55 24.5 24.5 NUM bam-8931 77 56 active active ADJ bam-8931 77 57 p05 p05 NOUN bam-8931 77 58 33 33 NUM bam-8931 77 59 m m NOUN bam-8931 77 60 74 74 NUM bam-8931 77 61 174 174 NUM bam-8931 77 62 24.4 24.4 NUM bam-8931 77 63 active active ADJ bam-8931 77 64 p06 p06 ADJ bam-8931 77 65 43 43 NUM bam-8931 77 66 m m NUM bam-8931 77 67 97 97 NUM bam-8931 77 68 180 180 NUM bam-8931 77 69 29.9 29.9 NUM bam-8931 77 70 active active ADJ bam-8931 77 71 p07 p07 NOUN bam-8931 77 72 23 23 NUM bam-8931 77 73 m m NOUN bam-8931 77 74 70 70 NUM bam-8931 77 75 180 180 NUM bam-8931 77 76 21.6 21.6 NUM bam-8931 77 77 professional professional ADJ bam-8931 77 78 football football NOUN bam-8931 77 79 player player NOUN bam-8931 77 80 p08 p08 NOUN bam-8931 77 81 69 69 NUM bam-8931 77 82 f f NOUN bam-8931 77 83 69 69 NUM bam-8931 77 84 168 168 NUM bam-8931 77 85 24.4 24.4 NUM bam-8931 77 86 sedentary sedentary ADJ bam-8931 77 87 p09 p09 NOUN bam-8931 77 88 58 58 NUM bam-8931 77 89 m m NUM bam-8931 77 90 72 72 NUM bam-8931 77 91 180 180 NUM bam-8931 77 92 22.2 22.2 NUM bam-8931 77 93 moderately moderately ADV bam-8931 77 94 active active ADJ bam-8931 77 95 p10 p10 NOUN bam-8931 77 96 48 48 NUM bam-8931 77 97 m m NUM bam-8931 77 98 69 69 NUM bam-8931 77 99 172 172 NUM bam-8931 77 100 23.3 23.3 NUM bam-8931 77 101 mildly mildly ADV bam-8931 77 102 active active ADJ bam-8931 77 103 p11 p11 NOUN bam-8931 77 104 30 30 NUM bam-8931 77 105 m m NOUN bam-8931 77 106 96 96 NUM bam-8931 77 107 196 196 NUM bam-8931 77 108 25.0 25.0 NUM bam-8931 77 109 active active ADJ bam-8931 77 110 p12 p12 ADJ bam-8931 77 111 28 28 NUM bam-8931 77 112 m m NOUN bam-8931 77 113 70 70 NUM bam-8931 77 114 178 178 NUM bam-8931 77 115 22.1 22.1 NUM bam-8931 77 116 active active ADJ bam-8931 77 117 p13 p13 NOUN bam-8931 77 118 32 32 NUM bam-8931 77 119 m m NUM bam-8931 77 120 70 70 NUM bam-8931 77 121 180 180 NUM bam-8931 77 122 21.6 21.6 NUM bam-8931 77 123 active active ADJ bam-8931 77 124 labels label NOUN bam-8931 77 125 in in ADP bam-8931 77 126 3rd 3rd ADJ bam-8931 77 127 column column NOUN bam-8931 77 128 refer refer VERB bam-8931 77 129 to to ADP bam-8931 77 130 : : PUNCT bam-8931 77 131 f f X bam-8931 77 132 : : PUNCT bam-8931 77 133 female female ADJ bam-8931 77 134 ; ; PUNCT bam-8931 77 135 m m NUM bam-8931 77 136 : : PUNCT bam-8931 77 137 male male ADJ bam-8931 77 138 . . PUNCT bam-8931 78 1 muscle muscle NOUN bam-8931 78 2 impairment impairment NOUN bam-8931 78 3 in in ADP bam-8931 78 4 pre pre ADJ bam-8931 78 5 - - ADJ bam-8931 78 6 cachexia cachexia ADJ bam-8931 78 7 cancer cancer NOUN bam-8931 78 8 patients patient NOUN bam-8931 78 9 eur eur PROPN bam-8931 78 10 j j PROPN bam-8931 78 11 transl transl PROPN bam-8931 78 12 myol myol ADV bam-8931 78 13 30 30 NUM bam-8931 78 14 ( ( PUNCT bam-8931 78 15 2 2 NUM bam-8931 78 16 ): ): PUNCT bam-8931 78 17 258 258 NUM bam-8931 78 18 - - SYM bam-8931 78 19 267 267 NUM bam-8931 78 20 , , PUNCT bam-8931 78 21 2020 2020 NUM bam-8931 78 22 261 261 NUM bam-8931 78 23 oxidative oxidative ADJ bam-8931 78 24 efficiency efficiency NOUN bam-8931 78 25 , , PUNCT bam-8931 78 26 a a DET bam-8931 78 27 two two NUM bam-8931 78 28 - - PUNCT bam-8931 78 29 way way NOUN bam-8931 78 30 anova anova X bam-8931 78 31 of of ADP bam-8931 78 32 “ " PUNCT bam-8931 78 33 group group NOUN bam-8931 78 34 ” " PUNCT bam-8931 78 35 ( ( PUNCT bam-8931 78 36 i.e. i.e. X bam-8931 78 37 , , PUNCT bam-8931 78 38 patients patient NOUN bam-8931 78 39 vs. vs. ADP bam-8931 78 40 control control NOUN bam-8931 78 41 group group PROPN bam-8931 78 42 ) ) PUNCT bam-8931 78 43 and and CCONJ bam-8931 78 44 “ " PUNCT bam-8931 78 45 time time NOUN bam-8931 78 46 ” " PUNCT bam-8931 78 47 ( ( PUNCT bam-8931 78 48 i.e. i.e. X bam-8931 78 49 , , PUNCT bam-8931 78 50 t0 t0 PROPN bam-8931 78 51 , , PUNCT bam-8931 78 52 t1 t1 NOUN bam-8931 78 53 , , PUNCT bam-8931 78 54 t2 t2 NOUN bam-8931 78 55 , , PUNCT bam-8931 78 56 t3 t3 PROPN bam-8931 78 57 , , PUNCT bam-8931 78 58 t4 t4 PROPN bam-8931 78 59 ) ) PUNCT bam-8931 78 60 with with ADP bam-8931 78 61 repeated repeat VERB bam-8931 78 62 measures measure NOUN bam-8931 78 63 on on ADP bam-8931 78 64 “ " PUNCT bam-8931 78 65 time time NOUN bam-8931 78 66 ” " PUNCT bam-8931 78 67 was be AUX bam-8931 78 68 used use VERB bam-8931 78 69 to to PART bam-8931 78 70 find find VERB bam-8931 78 71 significant significant ADJ bam-8931 78 72 differences difference NOUN bam-8931 78 73 in in ADP bam-8931 78 74 the the DET bam-8931 78 75 lactate lactate NOUN bam-8931 78 76 blood blood NOUN bam-8931 78 77 concentrations concentration NOUN bam-8931 78 78 . . PUNCT bam-8931 79 1 post post ADJ bam-8931 79 2 - - ADJ bam-8931 79 3 hoc hoc X bam-8931 79 4 an an DET bam-8931 79 5 unpaired unpaired ADJ bam-8931 79 6 t t NOUN bam-8931 79 7 - - PUNCT bam-8931 79 8 test test NOUN bam-8931 79 9 with with ADP bam-8931 79 10 bonferroni bonferroni NOUN bam-8931 79 11 correction correction NOUN bam-8931 79 12 ( ( PUNCT bam-8931 79 13 𝛼=0.05/5 𝛼=0.05/5 NOUN bam-8931 79 14 ) ) PUNCT bam-8931 79 15 was be AUX bam-8931 79 16 applied apply VERB bam-8931 79 17 to to PART bam-8931 79 18 identify identify VERB bam-8931 79 19 pairwise pairwise NOUN bam-8931 79 20 differences difference NOUN bam-8931 79 21 . . PUNCT bam-8931 80 1 data datum NOUN bam-8931 80 2 processing processing NOUN bam-8931 80 3 and and CCONJ bam-8931 80 4 statistical statistical ADJ bam-8931 80 5 analysis analysis NOUN bam-8931 80 6 were be AUX bam-8931 80 7 performed perform VERB bam-8931 80 8 using use VERB bam-8931 80 9 custom custom ADV bam-8931 80 10 - - PUNCT bam-8931 80 11 written write VERB bam-8931 80 12 matlab matlab NOUN bam-8931 80 13 ( ( PUNCT bam-8931 80 14 the the DET bam-8931 80 15 mathworks mathworks PROPN bam-8931 80 16 , , PUNCT bam-8931 80 17 inc inc PROPN bam-8931 80 18 . . PROPN bam-8931 80 19 , , PUNCT bam-8931 80 20 natick natick PROPN bam-8931 80 21 , , PUNCT bam-8931 80 22 ma ma PROPN bam-8931 80 23 , , PUNCT bam-8931 80 24 usa usa PROPN bam-8931 80 25 ) ) PUNCT bam-8931 80 26 scripts script NOUN bam-8931 80 27 . . PUNCT bam-8931 81 1 results result VERB bam-8931 81 2 twelve twelve NUM bam-8931 81 3 males male NOUN bam-8931 81 4 and and CCONJ bam-8931 81 5 one one NUM bam-8931 81 6 female female NOUN bam-8931 81 7 were be AUX bam-8931 81 8 enrolled enrol VERB bam-8931 81 9 ( ( PUNCT bam-8931 81 10 age age NOUN bam-8931 81 11 42.5 42.5 NUM bam-8931 81 12 ± ± NUM bam-8931 81 13 15.7 15.7 NUM bam-8931 81 14 years year NOUN bam-8931 81 15 , , PUNCT bam-8931 81 16 range range VERB bam-8931 81 17 23 23 NUM bam-8931 81 18 - - SYM bam-8931 81 19 69 69 NUM bam-8931 81 20 years year NOUN bam-8931 81 21 ) ) PUNCT bam-8931 81 22 . . PUNCT bam-8931 82 1 clinical clinical ADJ bam-8931 82 2 characteristics characteristic NOUN bam-8931 82 3 of of ADP bam-8931 82 4 the the DET bam-8931 82 5 included include VERB bam-8931 82 6 patients patient NOUN bam-8931 82 7 are be AUX bam-8931 82 8 summarised summarise VERB bam-8931 82 9 in in ADP bam-8931 82 10 table table NOUN bam-8931 82 11 1 1 NUM bam-8931 82 12 and and CCONJ bam-8931 82 13 table table NOUN bam-8931 82 14 2 2 NUM bam-8931 82 15 . . PUNCT bam-8931 83 1 no no DET bam-8931 83 2 relevant relevant ADJ bam-8931 83 3 comorbidities comorbiditie NOUN bam-8931 83 4 were be AUX bam-8931 83 5 present present ADJ bam-8931 83 6 and and CCONJ bam-8931 83 7 enrolled enrol VERB bam-8931 83 8 patients patient NOUN bam-8931 83 9 have have VERB bam-8931 83 10 active active ADJ bam-8931 83 11 to to ADP bam-8931 83 12 moderately moderately ADV bam-8931 83 13 - - PUNCT bam-8931 83 14 active active ADJ bam-8931 83 15 lifestyle lifestyle NOUN bam-8931 83 16 . . PUNCT bam-8931 84 1 patients patient NOUN bam-8931 84 2 ’ ' PUNCT bam-8931 84 3 anamnestic anamnestic ADJ bam-8931 84 4 data datum NOUN bam-8931 84 5 did do AUX bam-8931 84 6 not not PART bam-8931 84 7 show show VERB bam-8931 84 8 any any DET bam-8931 84 9 weight weight NOUN bam-8931 84 10 loss loss NOUN bam-8931 84 11 ( ( PUNCT bam-8931 84 12 larger large ADJ bam-8931 84 13 than than ADP bam-8931 84 14 5 5 NUM bam-8931 84 15 % % NOUN bam-8931 84 16 ) ) PUNCT bam-8931 84 17 in in ADP bam-8931 84 18 the the DET bam-8931 84 19 12 12 NUM bam-8931 84 20 months month NOUN bam-8931 84 21 before before ADP bam-8931 84 22 the the DET bam-8931 84 23 enrolment enrolment NOUN bam-8931 84 24 for for ADP bam-8931 84 25 this this DET bam-8931 84 26 study study NOUN bam-8931 84 27 . . PUNCT bam-8931 85 1 all all DET bam-8931 85 2 patients patient NOUN bam-8931 85 3 had have VERB bam-8931 85 4 no no DET bam-8931 85 5 signs sign NOUN bam-8931 85 6 of of ADP bam-8931 85 7 table table NOUN bam-8931 85 8 2 2 NUM bam-8931 85 9 . . PUNCT bam-8931 86 1 summary summary NOUN bam-8931 86 2 of of ADP bam-8931 86 3 main main ADJ bam-8931 86 4 clinical clinical ADJ bam-8931 86 5 features feature NOUN bam-8931 86 6 of of ADP bam-8931 86 7 cancer cancer NOUN bam-8931 86 8 patients patient NOUN bam-8931 86 9 recruited recruit VERB bam-8931 86 10 in in ADP bam-8931 86 11 this this DET bam-8931 86 12 study study NOUN bam-8931 86 13 . . PUNCT bam-8931 87 1 i i PRON bam-8931 87 2 d d PROPN bam-8931 87 3 cancer cancer NOUN bam-8931 87 4 location location NOUN bam-8931 87 5 comorbidities comorbiditie NOUN bam-8931 87 6 medications medication NOUN bam-8931 87 7 time time NOUN bam-8931 87 8 elapsed elapse VERB bam-8931 87 9 from from ADP bam-8931 87 10 diagnosis diagnosis NOUN bam-8931 87 11 ( ( PUNCT bam-8931 87 12 months month NOUN bam-8931 87 13 ) ) PUNCT bam-8931 87 14 treatment treatment NOUN bam-8931 87 15 p01 p01 NOUN bam-8931 87 16 mediastinal mediastinal ADJ bam-8931 87 17 + + CCONJ bam-8931 87 18 – – PUNCT bam-8931 87 19 – – PUNCT bam-8931 87 20 3 3 NUM bam-8931 87 21 ct ct PROPN bam-8931 87 22 p02 p02 X bam-8931 87 23 lung lung NOUN bam-8931 87 24 + + CCONJ bam-8931 87 25 copd copd PROPN bam-8931 87 26 baa baa PROPN bam-8931 87 27 24 24 NUM bam-8931 87 28 ct ct PROPN bam-8931 88 1 + + CCONJ bam-8931 88 2 rt rt PROPN bam-8931 88 3 p03 p03 PROPN bam-8931 88 4 pancreatic pancreatic PROPN bam-8931 88 5 + + CCONJ bam-8931 88 6 aht aht VERB bam-8931 88 7 acei acei NOUN bam-8931 88 8 2 2 NUM bam-8931 88 9 ct ct PROPN bam-8931 88 10 p04 p04 NOUN bam-8931 88 11 testicular testicular NOUN bam-8931 88 12 + + X bam-8931 88 13 – – PUNCT bam-8931 88 14 – – PUNCT bam-8931 88 15 22 22 NUM bam-8931 88 16 st st NOUN bam-8931 89 1 + + CCONJ bam-8931 89 2 ct ct PROPN bam-8931 89 3 p05 p05 ADJ bam-8931 89 4 testicular testicular NOUN bam-8931 89 5 – – PUNCT bam-8931 89 6 – – PUNCT bam-8931 89 7 4 4 NUM bam-8931 89 8 st st NOUN bam-8931 89 9 + + CCONJ bam-8931 89 10 ct ct PROPN bam-8931 89 11 p06 p06 ADJ bam-8931 89 12 testicular testicular NOUN bam-8931 89 13 + + CCONJ bam-8931 89 14 – – PUNCT bam-8931 89 15 – – PUNCT bam-8931 89 16 24 24 NUM bam-8931 89 17 st st NOUN bam-8931 89 18 + + CCONJ bam-8931 89 19 ct ct PROPN bam-8931 89 20 p07 p07 NOUN bam-8931 89 21 testicular testicular NOUN bam-8931 89 22 – – PUNCT bam-8931 89 23 – – PUNCT bam-8931 89 24 1 1 NUM bam-8931 89 25 st st NOUN bam-8931 89 26 + + NUM bam-8931 89 27 ct ct PROPN bam-8931 89 28 p08 p08 NOUN bam-8931 89 29 colon colon NOUN bam-8931 89 30 + + CCONJ bam-8931 89 31 h h PROPN bam-8931 89 32 statins statin NOUN bam-8931 89 33 3 3 NUM bam-8931 89 34 ct ct NOUN bam-8931 89 35 p09 p09 NOUN bam-8931 89 36 testicular testicular NOUN bam-8931 89 37 + + CCONJ bam-8931 89 38 – – PUNCT bam-8931 89 39 – – PUNCT bam-8931 89 40 61 61 NUM bam-8931 89 41 st+ st+ NOUN bam-8931 89 42 ct ct PROPN bam-8931 89 43 p10 p10 NOUN bam-8931 89 44 retromandibular retromandibular NOUN bam-8931 89 45 + + CCONJ bam-8931 89 46 – – PUNCT bam-8931 89 47 – – PUNCT bam-8931 89 48 12 12 NUM bam-8931 89 49 st st NOUN bam-8931 90 1 + + CCONJ bam-8931 90 2 ct ct PROPN bam-8931 90 3 + + PROPN bam-8931 90 4 rt rt PROPN bam-8931 90 5 p11 p11 ADJ bam-8931 90 6 testicular testicular NOUN bam-8931 90 7 – – PUNCT bam-8931 90 8 – – PUNCT bam-8931 90 9 3 3 NUM bam-8931 90 10 st st NOUN bam-8931 90 11 p12 p12 ADJ bam-8931 90 12 testicular testicular NOUN bam-8931 90 13 – – PUNCT bam-8931 90 14 – – PUNCT bam-8931 90 15 2 2 NUM bam-8931 90 16 st st NOUN bam-8931 90 17 + + CCONJ bam-8931 90 18 ct ct PROPN bam-8931 90 19 p13 p13 NOUN bam-8931 90 20 testicular testicular NOUN bam-8931 90 21 – – PUNCT bam-8931 90 22 – – PUNCT bam-8931 90 23 3 3 NUM bam-8931 90 24 st st NOUN bam-8931 90 25 + + CCONJ bam-8931 90 26 ct ct NUM bam-8931 90 27 labels label NOUN bam-8931 90 28 in in ADP bam-8931 90 29 2nd 2nd ADJ bam-8931 90 30 , , PUNCT bam-8931 90 31 3rd 3rd ADJ bam-8931 90 32 , , PUNCT bam-8931 90 33 4th 4th ADJ bam-8931 90 34 , , PUNCT bam-8931 90 35 and and CCONJ bam-8931 90 36 6th 6th ADJ bam-8931 90 37 columns column NOUN bam-8931 90 38 refer refer VERB bam-8931 90 39 to to ADP bam-8931 90 40 : : PUNCT bam-8931 90 41 + + ADJ bam-8931 90 42 : : PUNCT bam-8931 90 43 presence presence NOUN bam-8931 90 44 of of ADP bam-8931 90 45 metastasis metastasis NOUN bam-8931 90 46 ; ; PUNCT bam-8931 90 47 copd copd NOUN bam-8931 90 48 : : PUNCT bam-8931 90 49 chronic chronic ADJ bam-8931 90 50 obstructive obstructive ADJ bam-8931 90 51 pulmonary pulmonary ADJ bam-8931 90 52 disease disease NOUN bam-8931 90 53 ; ; PUNCT bam-8931 90 54 aht aht NOUN bam-8931 90 55 : : PUNCT bam-8931 90 56 arterial arterial NOUN bam-8931 90 57 hypertension hypertension NOUN bam-8931 90 58 ; ; PUNCT bam-8931 90 59 h h NOUN bam-8931 90 60 : : PUNCT bam-8931 90 61 hypercholesterolemia hypercholesterolemia NOUN bam-8931 90 62 ; ; PUNCT bam-8931 90 63 baa baa NOUN bam-8931 90 64 : : PUNCT bam-8931 90 65 beta beta NOUN bam-8931 90 66 - - PUNCT bam-8931 90 67 adrenergic adrenergic ADJ bam-8931 90 68 agonist agonist NOUN bam-8931 90 69 ; ; PUNCT bam-8931 90 70 acei acei NOUN bam-8931 90 71 : : PUNCT bam-8931 90 72 angiotensinconverting angiotensinconverte VERB bam-8931 90 73 enzyme enzyme NOUN bam-8931 90 74 inhibitors inhibitor NOUN bam-8931 90 75 ; ; PUNCT bam-8931 90 76 ct ct X bam-8931 90 77 : : PUNCT bam-8931 90 78 chemotherapy chemotherapy NOUN bam-8931 90 79 ; ; PUNCT bam-8931 90 80 rt rt ADJ bam-8931 90 81 : : PUNCT bam-8931 90 82 radiotherapy radiotherapy PROPN bam-8931 90 83 ; ; PUNCT bam-8931 90 84 st st ADJ bam-8931 90 85 : : PUNCT bam-8931 90 86 surgical surgical ADJ bam-8931 90 87 therapy therapy NOUN bam-8931 90 88 . . PUNCT bam-8931 91 1 table table NOUN bam-8931 91 2 3 3 NUM bam-8931 91 3 . . X bam-8931 91 4 demographic demographic ADJ bam-8931 91 5 and and CCONJ bam-8931 91 6 anthropometrics anthropometric NOUN bam-8931 91 7 of of ADP bam-8931 91 8 controls control NOUN bam-8931 91 9 . . PUNCT bam-8931 92 1 i i PRON bam-8931 92 2 d d PROPN bam-8931 92 3 age age NOUN bam-8931 92 4 ( ( PUNCT bam-8931 92 5 yr yr NOUN bam-8931 92 6 ) ) PUNCT bam-8931 92 7 sex sex NOUN bam-8931 92 8 weight weight NOUN bam-8931 92 9 ( ( PUNCT bam-8931 92 10 kg kg NOUN bam-8931 92 11 ) ) PUNCT bam-8931 92 12 height height NOUN bam-8931 92 13 ( ( PUNCT bam-8931 92 14 cm cm NOUN bam-8931 92 15 ) ) PUNCT bam-8931 92 16 bmi bmi NOUN bam-8931 92 17 ( ( PUNCT bam-8931 92 18 kg kg NOUN bam-8931 92 19 / / SYM bam-8931 92 20 m2 m2 PROPN bam-8931 92 21 ) ) PUNCT bam-8931 92 22 level level NOUN bam-8931 92 23 of of ADP bam-8931 92 24 physical physical ADJ bam-8931 92 25 exercises exercise NOUN bam-8931 92 26 c01 c01 PROPN bam-8931 92 27 22 22 NUM bam-8931 92 28 m m PROPN bam-8931 92 29 70 70 NUM bam-8931 92 30 185 185 NUM bam-8931 92 31 20,5 20,5 NUM bam-8931 92 32 active active ADJ bam-8931 92 33 c02 c02 NOUN bam-8931 92 34 30 30 NUM bam-8931 92 35 m m NOUN bam-8931 92 36 75 75 NUM bam-8931 92 37 175 175 NUM bam-8931 92 38 24,5 24,5 NUM bam-8931 92 39 professional professional ADJ bam-8931 92 40 football football NOUN bam-8931 92 41 player player NOUN bam-8931 92 42 c03 c03 PROPN bam-8931 92 43 40 40 NUM bam-8931 92 44 m m NOUN bam-8931 92 45 78 78 NUM bam-8931 92 46 177 177 NUM bam-8931 92 47 24,9 24,9 NUM bam-8931 92 48 active active ADJ bam-8931 92 49 c04 c04 NOUN bam-8931 93 1 73 73 NUM bam-8931 93 2 f f NOUN bam-8931 93 3 60 60 NUM bam-8931 93 4 160 160 NUM bam-8931 93 5 23,4 23,4 NUM bam-8931 93 6 mildly mildly ADV bam-8931 93 7 active active ADJ bam-8931 93 8 c05 c05 NOUN bam-8931 93 9 73 73 NUM bam-8931 93 10 m m PROPN bam-8931 93 11 59 59 NUM bam-8931 93 12 168 168 NUM bam-8931 93 13 20,9 20,9 NUM bam-8931 93 14 moderately moderately ADV bam-8931 93 15 active active ADJ bam-8931 93 16 c06 c06 NOUN bam-8931 93 17 33 33 NUM bam-8931 93 18 m m NOUN bam-8931 93 19 95 95 NUM bam-8931 93 20 185 185 NUM bam-8931 93 21 27,8 27,8 NUM bam-8931 93 22 weightlifters weightlifter NOUN bam-8931 93 23 c07 c07 NOUN bam-8931 93 24 43 43 NUM bam-8931 93 25 m m PROPN bam-8931 93 26 86 86 NUM bam-8931 93 27 170 170 NUM bam-8931 93 28 29,8 29,8 ADJ bam-8931 93 29 active active ADJ bam-8931 93 30 c08 c08 NOUN bam-8931 93 31 52 52 NUM bam-8931 93 32 m m NOUN bam-8931 93 33 92 92 NUM bam-8931 93 34 180 180 NUM bam-8931 93 35 28,4 28,4 NUM bam-8931 93 36 sedentary sedentary ADJ bam-8931 93 37 c09 c09 NOUN bam-8931 93 38 52 52 NUM bam-8931 93 39 f f NOUN bam-8931 93 40 79 79 NUM bam-8931 93 41 165 165 NUM bam-8931 93 42 29,0 29,0 NUM bam-8931 93 43 active active ADJ bam-8931 93 44 c10 c10 VERB bam-8931 93 45 77 77 NUM bam-8931 93 46 m m PROPN bam-8931 93 47 70 70 NUM bam-8931 93 48 178 178 NUM bam-8931 93 49 22,1 22,1 NUM bam-8931 93 50 mildly mildly ADV bam-8931 93 51 active active ADJ bam-8931 93 52 c11 c11 NOUN bam-8931 93 53 37 37 NUM bam-8931 93 54 m m NOUN bam-8931 93 55 76 76 NUM bam-8931 93 56 178 178 NUM bam-8931 93 57 24,0 24,0 NUM bam-8931 93 58 active active ADJ bam-8931 93 59 c12 c12 NOUN bam-8931 93 60 59 59 NUM bam-8931 93 61 m m NOUN bam-8931 93 62 75 75 NUM bam-8931 93 63 173 173 NUM bam-8931 93 64 25,1 25,1 NUM bam-8931 93 65 moderately moderately ADV bam-8931 93 66 active active ADJ bam-8931 93 67 c13 c13 NOUN bam-8931 93 68 57 57 NUM bam-8931 93 69 f f NOUN bam-8931 93 70 70 70 NUM bam-8931 93 71 168 168 NUM bam-8931 93 72 24,8 24,8 NUM bam-8931 93 73 active active ADJ bam-8931 93 74 c14 c14 NOUN bam-8931 93 75 59 59 NUM bam-8931 93 76 m m NUM bam-8931 93 77 88 88 NUM bam-8931 93 78 175 175 NUM bam-8931 93 79 28,7 28,7 PRON bam-8931 93 80 moderately moderately ADV bam-8931 93 81 active active ADJ bam-8931 93 82 c15 c15 NOUN bam-8931 93 83 57 57 NUM bam-8931 93 84 m m NOUN bam-8931 93 85 105 105 NUM bam-8931 93 86 182 182 NUM bam-8931 93 87 31,7 31,7 NUM bam-8931 93 88 sedentary sedentary ADJ bam-8931 93 89 labels label NOUN bam-8931 93 90 in in ADP bam-8931 93 91 3rd 3rd ADJ bam-8931 93 92 column column NOUN bam-8931 93 93 refer refer VERB bam-8931 93 94 to to ADP bam-8931 93 95 : : PUNCT bam-8931 93 96 f f X bam-8931 93 97 : : PUNCT bam-8931 93 98 female female ADJ bam-8931 93 99 ; ; PUNCT bam-8931 93 100 m m NUM bam-8931 93 101 : : PUNCT bam-8931 93 102 male male ADJ bam-8931 93 103 . . PUNCT bam-8931 94 1 muscle muscle NOUN bam-8931 94 2 impairment impairment NOUN bam-8931 94 3 in in ADP bam-8931 94 4 pre pre ADJ bam-8931 94 5 - - ADJ bam-8931 94 6 cachexia cachexia ADJ bam-8931 94 7 cancer cancer NOUN bam-8931 94 8 patients patient NOUN bam-8931 94 9 eur eur PROPN bam-8931 94 10 j j PROPN bam-8931 94 11 transl transl PROPN bam-8931 94 12 myol myol ADV bam-8931 94 13 30 30 NUM bam-8931 94 14 ( ( PUNCT bam-8931 94 15 2 2 NUM bam-8931 94 16 ): ): PUNCT bam-8931 94 17 258 258 NUM bam-8931 94 18 - - SYM bam-8931 94 19 267 267 NUM bam-8931 94 20 , , PUNCT bam-8931 94 21 2020 2020 NUM bam-8931 94 22 262 262 NUM bam-8931 94 23 cachexia cachexia NOUN bam-8931 94 24 nor nor CCONJ bam-8931 94 25 pre pre ADJ bam-8931 94 26 - - NOUN bam-8931 94 27 cachexia cachexia ADJ bam-8931 94 28 . . PUNCT bam-8931 95 1 for for ADP bam-8931 95 2 each each DET bam-8931 95 3 patient patient NOUN bam-8931 95 4 , , PUNCT bam-8931 95 5 the the DET bam-8931 95 6 bmi bmi NOUN bam-8931 95 7 was be AUX bam-8931 95 8 greater great ADJ bam-8931 95 9 than than ADP bam-8931 95 10 20 20 NUM bam-8931 95 11 kg kg NOUN bam-8931 95 12 / / SYM bam-8931 95 13 m2 m2 PROPN bam-8931 95 14 ( ( PUNCT bam-8931 95 15 24.6 24.6 NUM bam-8931 95 16 ± ± NUM bam-8931 95 17 3.2 3.2 NUM bam-8931 95 18 ) ) PUNCT bam-8931 95 19 ( ( PUNCT bam-8931 95 20 see see VERB bam-8931 95 21 table table NOUN bam-8931 95 22 1 1 NUM bam-8931 95 23 ) ) PUNCT bam-8931 95 24 . . PUNCT bam-8931 96 1 twelve twelve NUM bam-8931 96 2 males male NOUN bam-8931 96 3 and and CCONJ bam-8931 96 4 three three NUM bam-8931 96 5 females female NOUN bam-8931 96 6 were be AUX bam-8931 96 7 enrolled enrol VERB bam-8931 96 8 as as ADP bam-8931 96 9 a a DET bam-8931 96 10 control control NOUN bam-8931 96 11 group group NOUN bam-8931 96 12 ( ( PUNCT bam-8931 96 13 table table NOUN bam-8931 96 14 3 3 NUM bam-8931 96 15 ) ) PUNCT bam-8931 96 16 . . PUNCT bam-8931 97 1 there there PRON bam-8931 97 2 were be VERB bam-8931 97 3 no no DET bam-8931 97 4 significant significant ADJ bam-8931 97 5 differences difference NOUN bam-8931 97 6 between between ADP bam-8931 97 7 patients patient NOUN bam-8931 97 8 and and CCONJ bam-8931 97 9 controls control NOUN bam-8931 97 10 both both PRON bam-8931 97 11 for for ADP bam-8931 97 12 age age NOUN bam-8931 97 13 and and CCONJ bam-8931 97 14 bmi bmi NOUN bam-8931 97 15 ( ( PUNCT bam-8931 97 16 age age NOUN bam-8931 97 17 : : PUNCT bam-8931 97 18 49.1 49.1 NUM bam-8931 97 19 ± ± NUM bam-8931 97 20 17.5 17.5 NUM bam-8931 97 21 years year NOUN bam-8931 97 22 , , PUNCT bam-8931 97 23 range range VERB bam-8931 97 24 22 22 NUM bam-8931 97 25 - - SYM bam-8931 97 26 77 77 NUM bam-8931 97 27 years year NOUN bam-8931 97 28 ; ; PUNCT bam-8931 97 29 bmi bmi PROPN bam-8931 97 30 : : PUNCT bam-8931 97 31 25.7 25.7 NUM bam-8931 97 32 ± ± NUM bam-8931 97 33 2.8 2.8 NUM bam-8931 97 34 ) ) PUNCT bam-8931 97 35 . . PUNCT bam-8931 98 1 all all DET bam-8931 98 2 subjects subject NOUN bam-8931 98 3 included include VERB bam-8931 98 4 in in ADP bam-8931 98 5 the the DET bam-8931 98 6 study study NOUN bam-8931 98 7 performed perform VERB bam-8931 98 8 the the DET bam-8931 98 9 required require VERB bam-8931 98 10 tasks task NOUN bam-8931 98 11 without without ADP bam-8931 98 12 reporting report VERB bam-8931 98 13 any any DET bam-8931 98 14 side side NOUN bam-8931 98 15 effects effect NOUN bam-8931 98 16 . . PUNCT bam-8931 99 1 regarding regard VERB bam-8931 99 2 the the DET bam-8931 99 3 lactate lactate NOUN bam-8931 99 4 test test NOUN bam-8931 99 5 , , PUNCT bam-8931 99 6 generally generally ADV bam-8931 99 7 healthy healthy ADJ bam-8931 99 8 subjects subject NOUN bam-8931 99 9 walked walk VERB bam-8931 99 10 on on ADP bam-8931 99 11 treadmill treadmill NOUN bam-8931 99 12 longer long ADV bam-8931 99 13 than than ADP bam-8931 99 14 patients patient NOUN bam-8931 99 15 ( ( PUNCT bam-8931 99 16 healthy healthy ADJ bam-8931 99 17 subject subject NOUN bam-8931 99 18 : : PUNCT bam-8931 99 19 19.6 19.6 NUM bam-8931 99 20 ± ± NUM bam-8931 99 21 3.9 3.9 NUM bam-8931 99 22 minutes minute NOUN bam-8931 99 23 vs. vs. ADP bam-8931 99 24 patients patient NOUN bam-8931 99 25 : : PUNCT bam-8931 99 26 15.7 15.7 NUM bam-8931 99 27 ± ± NUM bam-8931 99 28 7.7 7.7 NUM bam-8931 99 29 minutes minute NOUN bam-8931 99 30 ) ) PUNCT bam-8931 99 31 ( ( PUNCT bam-8931 99 32 figure figure NOUN bam-8931 99 33 1 1 NUM bam-8931 99 34 ) ) PUNCT bam-8931 99 35 . . PUNCT bam-8931 100 1 the the DET bam-8931 100 2 blood blood NOUN bam-8931 100 3 concentration concentration NOUN bam-8931 100 4 of of ADP bam-8931 100 5 lactate lactate NOUN bam-8931 100 6 increased increase VERB bam-8931 100 7 during during ADP bam-8931 100 8 the the DET bam-8931 100 9 exercise exercise NOUN bam-8931 100 10 and and CCONJ bam-8931 100 11 decreased decrease VERB bam-8931 100 12 during during ADP bam-8931 100 13 the the DET bam-8931 100 14 recovery recovery NOUN bam-8931 100 15 phase phase NOUN bam-8931 100 16 in in ADP bam-8931 100 17 both both DET bam-8931 100 18 groups group NOUN bam-8931 100 19 ( ( PUNCT bam-8931 100 20 i.e. i.e. X bam-8931 100 21 , , PUNCT bam-8931 100 22 patients patient NOUN bam-8931 100 23 and and CCONJ bam-8931 100 24 controls control NOUN bam-8931 100 25 ) ) PUNCT bam-8931 100 26 . . PUNCT bam-8931 101 1 two two NUM bam-8931 101 2 - - PUNCT bam-8931 101 3 way way NOUN bam-8931 101 4 anova anova PROPN bam-8931 101 5 revealed reveal VERB bam-8931 101 6 a a DET bam-8931 101 7 highly highly ADV bam-8931 101 8 significant significant ADJ bam-8931 101 9 difference difference NOUN bam-8931 101 10 in in ADP bam-8931 101 11 both both DET bam-8931 101 12 factors factor NOUN bam-8931 101 13 ( ( PUNCT bam-8931 101 14 “ " PUNCT bam-8931 101 15 group group NOUN bam-8931 101 16 ” " PUNCT bam-8931 101 17 and and CCONJ bam-8931 101 18 “ " PUNCT bam-8931 101 19 time time NOUN bam-8931 101 20 ” " PUNCT bam-8931 101 21 ) ) PUNCT bam-8931 101 22 ( ( PUNCT bam-8931 101 23 p<0.001 p<0.001 PROPN bam-8931 101 24 ) ) PUNCT bam-8931 101 25 . . PUNCT bam-8931 102 1 in in ADP bam-8931 102 2 particular particular ADJ bam-8931 102 3 t t NOUN bam-8931 102 4 - - PUNCT bam-8931 102 5 test test NOUN bam-8931 102 6 between between ADP bam-8931 102 7 “ " PUNCT bam-8931 102 8 groups group NOUN bam-8931 102 9 ” " PUNCT bam-8931 102 10 ( ( PUNCT bam-8931 102 11 i.e. i.e. X bam-8931 102 12 , , PUNCT bam-8931 102 13 patients patient NOUN bam-8931 102 14 vs. vs. ADP bam-8931 102 15 controls control NOUN bam-8931 102 16 ) ) PUNCT bam-8931 102 17 showed show VERB bam-8931 102 18 that that SCONJ bam-8931 102 19 the the DET bam-8931 102 20 blood blood NOUN bam-8931 102 21 lactate lactate NOUN bam-8931 102 22 concentration concentration NOUN bam-8931 102 23 before before ADP bam-8931 102 24 starting start VERB bam-8931 102 25 the the DET bam-8931 102 26 exercise exercise NOUN bam-8931 102 27 was be AUX bam-8931 102 28 significantly significantly ADV bam-8931 102 29 higher high ADJ bam-8931 102 30 ( ( PUNCT bam-8931 102 31 p<0.001 p<0.001 X bam-8931 102 32 ) ) PUNCT bam-8931 102 33 in in ADP bam-8931 102 34 cancer cancer NOUN bam-8931 102 35 patients patient NOUN bam-8931 102 36 compared compare VERB bam-8931 102 37 to to ADP bam-8931 102 38 the the DET bam-8931 102 39 controls control NOUN bam-8931 102 40 ( ( PUNCT bam-8931 102 41 respectively respectively ADV bam-8931 102 42 18.07 18.07 NUM bam-8931 102 43 ± ± NUM bam-8931 102 44 4.94 4.94 NUM bam-8931 102 45 and and CCONJ bam-8931 102 46 11.26 11.26 NUM bam-8931 102 47 ± ± NUM bam-8931 102 48 3.31 3.31 NUM bam-8931 102 49 mg mg PROPN bam-8931 102 50 / / SYM bam-8931 102 51 dl dl PROPN bam-8931 102 52 ) ) PUNCT bam-8931 102 53 . . PUNCT bam-8931 103 1 this this DET bam-8931 103 2 behaviour behaviour NOUN bam-8931 103 3 was be AUX bam-8931 103 4 maintained maintain VERB bam-8931 103 5 also also ADV bam-8931 103 6 at at ADP bam-8931 103 7 any any DET bam-8931 103 8 given give VERB bam-8931 103 9 time time NOUN bam-8931 103 10 during during ADP bam-8931 103 11 the the DET bam-8931 103 12 recovery recovery NOUN bam-8931 103 13 fig fig NOUN bam-8931 103 14 1 1 NUM bam-8931 103 15 . . PUNCT bam-8931 104 1 endurance endurance NOUN bam-8931 104 2 : : PUNCT bam-8931 105 1 mean mean VERB bam-8931 105 2 and and CCONJ bam-8931 105 3 one one NUM bam-8931 105 4 standard standard ADJ bam-8931 105 5 deviation deviation NOUN bam-8931 105 6 of of ADP bam-8931 105 7 endurance endurance NOUN bam-8931 105 8 ( ( PUNCT bam-8931 105 9 minutes minute NOUN bam-8931 105 10 ) ) PUNCT bam-8931 105 11 during during ADP bam-8931 105 12 incremental incremental ADJ bam-8931 105 13 sub sub ADJ bam-8931 105 14 - - ADJ bam-8931 105 15 maximal maximal ADJ bam-8931 105 16 aerobic aerobic ADJ bam-8931 105 17 exercise exercise NOUN bam-8931 105 18 on on ADP bam-8931 105 19 a a DET bam-8931 105 20 treadmill treadmill NOUN bam-8931 105 21 in in ADP bam-8931 105 22 healthy healthy ADJ bam-8931 105 23 subjects subject NOUN bam-8931 105 24 ( ( PUNCT bam-8931 105 25 lgrey lgrey PROPN bam-8931 105 26 ) ) PUNCT bam-8931 105 27 and and CCONJ bam-8931 105 28 patients patient NOUN bam-8931 105 29 ( ( PUNCT bam-8931 105 30 blak blak PROPN bam-8931 105 31 ) ) PUNCT bam-8931 105 32 . . PUNCT bam-8931 106 1 fig fig NOUN bam-8931 106 2 2 2 NUM bam-8931 106 3 . . PUNCT bam-8931 106 4 blood blood NOUN bam-8931 106 5 concentration concentration NOUN bam-8931 106 6 of of ADP bam-8931 106 7 lactate lactate NOUN bam-8931 106 8 : : PUNCT bam-8931 107 1 mean mean VERB bam-8931 107 2 and and CCONJ bam-8931 107 3 one one NUM bam-8931 107 4 standard standard ADJ bam-8931 107 5 deviation deviation NOUN bam-8931 107 6 of of ADP bam-8931 107 7 blood blood NOUN bam-8931 107 8 concentration concentration NOUN bam-8931 107 9 of of ADP bam-8931 107 10 lactate lactate NOUN bam-8931 107 11 , , PUNCT bam-8931 107 12 before before ADP bam-8931 107 13 ( ( PUNCT bam-8931 107 14 t0 t0 NOUN bam-8931 107 15 ) ) PUNCT bam-8931 107 16 , , PUNCT bam-8931 107 17 at at ADP bam-8931 107 18 the the DET bam-8931 107 19 end end NOUN bam-8931 107 20 ( ( PUNCT bam-8931 107 21 t1 t1 NOUN bam-8931 107 22 ) ) PUNCT bam-8931 107 23 , , PUNCT bam-8931 107 24 and and CCONJ bam-8931 107 25 after after ADP bam-8931 107 26 ( ( PUNCT bam-8931 107 27 t2=5 t2=5 PROPN bam-8931 107 28 ’ ' PUNCT bam-8931 107 29 , , PUNCT bam-8931 107 30 t3=10 t3=10 PROPN bam-8931 107 31 ’ ' PUNCT bam-8931 107 32 , , PUNCT bam-8931 107 33 t4=30 t4=30 PROPN bam-8931 107 34 ’ ' PUNCT bam-8931 107 35 ) ) PUNCT bam-8931 107 36 resistance resistance NOUN bam-8931 107 37 exercise exercise NOUN bam-8931 107 38 ( ( PUNCT bam-8931 107 39 an an DET bam-8931 107 40 incremental incremental ADJ bam-8931 107 41 sub sub ADJ bam-8931 107 42 - - ADJ bam-8931 107 43 maximal maximal ADJ bam-8931 107 44 aerobic aerobic ADJ bam-8931 107 45 exercise exercise NOUN bam-8931 107 46 on on ADP bam-8931 107 47 a a DET bam-8931 107 48 treadmill treadmill NOUN bam-8931 107 49 ) ) PUNCT bam-8931 107 50 . . PUNCT bam-8931 108 1 dark dark ADJ bam-8931 108 2 grey grey PROPN bam-8931 108 3 denotes denote NOUN bam-8931 108 4 oncologic oncologic ADJ bam-8931 108 5 patients patient NOUN bam-8931 108 6 , , PUNCT bam-8931 108 7 light light ADJ bam-8931 108 8 grey grey ADJ bam-8931 108 9 subjects subject NOUN bam-8931 108 10 of of ADP bam-8931 108 11 control control NOUN bam-8931 108 12 group group NOUN bam-8931 108 13 . . PUNCT bam-8931 109 1 the the DET bam-8931 109 2 label label NOUN bam-8931 109 3 * * PUNCT bam-8931 109 4 * * PUNCT bam-8931 109 5 highlights highlight NOUN bam-8931 109 6 strong strong ADJ bam-8931 109 7 significant significant ADJ bam-8931 109 8 differences difference NOUN bam-8931 109 9 between between ADP bam-8931 109 10 healthy healthy ADJ bam-8931 109 11 and and CCONJ bam-8931 109 12 patients patient NOUN bam-8931 109 13 ( ( PUNCT bam-8931 109 14 p p X bam-8931 109 15 < < X bam-8931 109 16 0.001 0.001 NUM bam-8931 109 17 ) ) PUNCT bam-8931 109 18 . . PUNCT bam-8931 110 1 fig3 fig3 PROPN bam-8931 110 2 . . PUNCT bam-8931 111 1 maximal maximal ADJ bam-8931 111 2 voluntary voluntary ADJ bam-8931 111 3 contraction contraction NOUN bam-8931 111 4 : : PUNCT bam-8931 111 5 box box NOUN bam-8931 111 6 plot plot NOUN bam-8931 111 7 of of ADP bam-8931 111 8 maximal maximal ADJ bam-8931 111 9 voluntary voluntary ADJ bam-8931 111 10 contraction contraction NOUN bam-8931 111 11 parameter parameter NOUN bam-8931 111 12 ( ( PUNCT bam-8931 111 13 n n CCONJ bam-8931 111 14 ) ) PUNCT bam-8931 111 15 for for ADP bam-8931 111 16 patients patient NOUN bam-8931 111 17 ( ( PUNCT bam-8931 111 18 left leave VERB bam-8931 111 19 box box NOUN bam-8931 111 20 plot plot NOUN bam-8931 111 21 ) ) PUNCT bam-8931 111 22 and and CCONJ bam-8931 111 23 healthy healthy ADJ bam-8931 111 24 subjects subject NOUN bam-8931 111 25 ( ( PUNCT bam-8931 111 26 right right PROPN bam-8931 111 27 box box PROPN bam-8931 111 28 plot plot NOUN bam-8931 111 29 ) ) PUNCT bam-8931 111 30 . . PUNCT bam-8931 112 1 top top ADJ bam-8931 112 2 panel panel NOUN bam-8931 112 3 : : PUNCT bam-8931 112 4 knee knee NOUN bam-8931 112 5 extension extension NOUN bam-8931 112 6 . . PUNCT bam-8931 113 1 bottom bottom ADJ bam-8931 113 2 panel panel NOUN bam-8931 113 3 : : PUNCT bam-8931 113 4 handgrip handgrip NOUN bam-8931 113 5 . . PUNCT bam-8931 114 1 muscle muscle NOUN bam-8931 114 2 impairment impairment NOUN bam-8931 114 3 in in ADP bam-8931 114 4 pre pre ADJ bam-8931 114 5 - - ADJ bam-8931 114 6 cachexia cachexia ADJ bam-8931 114 7 cancer cancer NOUN bam-8931 114 8 patients patient NOUN bam-8931 114 9 eur eur PROPN bam-8931 114 10 j j PROPN bam-8931 114 11 transl transl PROPN bam-8931 114 12 myol myol ADV bam-8931 114 13 30 30 NUM bam-8931 114 14 ( ( PUNCT bam-8931 114 15 2 2 NUM bam-8931 114 16 ): ): PUNCT bam-8931 114 17 258 258 NUM bam-8931 114 18 - - SYM bam-8931 114 19 267 267 NUM bam-8931 114 20 , , PUNCT bam-8931 114 21 2020 2020 NUM bam-8931 114 22 263 263 NUM bam-8931 114 23 period period NOUN bam-8931 114 24 ( ( PUNCT bam-8931 114 25 i.e. i.e. X bam-8931 114 26 , , PUNCT bam-8931 114 27 t1 t1 NOUN bam-8931 114 28 , , PUNCT bam-8931 114 29 t2 t2 NOUN bam-8931 114 30 , , PUNCT bam-8931 114 31 t3 t3 PROPN bam-8931 114 32 , , PUNCT bam-8931 114 33 t4 t4 PROPN bam-8931 114 34 ) ) PUNCT bam-8931 114 35 ( ( PUNCT bam-8931 114 36 p<0.001 p<0.001 X bam-8931 114 37 ) ) PUNCT bam-8931 114 38 ( ( PUNCT bam-8931 114 39 figure figure NOUN bam-8931 114 40 2 2 NUM bam-8931 114 41 ) ) PUNCT bam-8931 114 42 . . PUNCT bam-8931 115 1 the the DET bam-8931 115 2 mean mean ADJ bam-8931 115 3 values value NOUN bam-8931 115 4 of of ADP bam-8931 115 5 the the DET bam-8931 115 6 patients patient NOUN bam-8931 115 7 ’ ' PUNCT bam-8931 115 8 maximal maximal ADJ bam-8931 115 9 strength strength NOUN bam-8931 115 10 were be AUX bam-8931 115 11 360.13 360.13 NUM bam-8931 115 12 ± ± NUM bam-8931 115 13 129.83 129.83 NUM bam-8931 115 14 n n NOUN bam-8931 115 15 for for ADP bam-8931 115 16 knee knee NOUN bam-8931 115 17 extension extension NOUN bam-8931 115 18 and and CCONJ bam-8931 115 19 313.43 313.43 NUM bam-8931 115 20 ± ± NUM bam-8931 115 21 94.39 94.39 NUM bam-8931 115 22 n n PROPN bam-8931 115 23 for for ADP bam-8931 115 24 handgrip handgrip NOUN bam-8931 115 25 tasks task NOUN bam-8931 115 26 . . PUNCT bam-8931 116 1 the the DET bam-8931 116 2 mean mean ADJ bam-8931 116 3 values value NOUN bam-8931 116 4 for for ADP bam-8931 116 5 healthy healthy ADJ bam-8931 116 6 subjects subject NOUN bam-8931 116 7 were be AUX bam-8931 116 8 423.59 423.59 NUM bam-8931 116 9 ± ± NUM bam-8931 116 10 160.35 160.35 NUM bam-8931 116 11 n n NOUN bam-8931 116 12 and and CCONJ bam-8931 116 13 393.27 393.27 NUM bam-8931 116 14 ± ± NUM bam-8931 116 15 127.60 127.60 NUM bam-8931 116 16 n n CCONJ bam-8931 116 17 , , PUNCT bam-8931 116 18 ( ( PUNCT bam-8931 116 19 respectively respectively ADV bam-8931 116 20 for for ADP bam-8931 116 21 knee knee NOUN bam-8931 116 22 and and CCONJ bam-8931 116 23 handgrip handgrip NOUN bam-8931 116 24 tasks task NOUN bam-8931 116 25 ) ) PUNCT bam-8931 116 26 . . PUNCT bam-8931 117 1 although although SCONJ bam-8931 117 2 there there PRON bam-8931 117 3 was be VERB bam-8931 117 4 a a DET bam-8931 117 5 trend trend NOUN bam-8931 117 6 toward toward ADP bam-8931 117 7 a a DET bam-8931 117 8 lower low ADJ bam-8931 117 9 maximum maximum ADJ bam-8931 117 10 voluntary voluntary ADJ bam-8931 117 11 strength strength NOUN bam-8931 117 12 , , PUNCT bam-8931 117 13 in in ADP bam-8931 117 14 both both CCONJ bam-8931 117 15 lower low ADJ bam-8931 117 16 and and CCONJ bam-8931 117 17 higher high ADJ bam-8931 117 18 limbs limb NOUN bam-8931 117 19 , , PUNCT bam-8931 117 20 in in ADP bam-8931 117 21 patients patient NOUN bam-8931 117 22 compared compare VERB bam-8931 117 23 to to ADP bam-8931 117 24 the the DET bam-8931 117 25 control control NOUN bam-8931 117 26 group group NOUN bam-8931 117 27 , , PUNCT bam-8931 117 28 the the DET bam-8931 117 29 statistical statistical ADJ bam-8931 117 30 test test NOUN bam-8931 117 31 did do AUX bam-8931 117 32 not not PART bam-8931 117 33 reveal reveal VERB bam-8931 117 34 any any DET bam-8931 117 35 significance significance NOUN bam-8931 117 36 ( ( PUNCT bam-8931 117 37 figure figure NOUN bam-8931 117 38 3 3 NUM bam-8931 117 39 ) ) PUNCT bam-8931 117 40 . . PUNCT bam-8931 118 1 the the DET bam-8931 118 2 fatigue fatigue NOUN bam-8931 118 3 test test NOUN bam-8931 118 4 showed show VERB bam-8931 118 5 that that SCONJ bam-8931 118 6 the the DET bam-8931 118 7 slope slope NOUN bam-8931 118 8 of of ADP bam-8931 118 9 the the DET bam-8931 118 10 regression regression NOUN bam-8931 118 11 line line NOUN bam-8931 118 12 ( ( PUNCT bam-8931 118 13 i.e. i.e. X bam-8931 118 14 , , PUNCT bam-8931 118 15 the the DET bam-8931 118 16 percentage percentage NOUN bam-8931 118 17 of of ADP bam-8931 118 18 decrement decrement NOUN bam-8931 118 19 of of ADP bam-8931 118 20 holding hold VERB bam-8931 118 21 strength strength NOUN bam-8931 118 22 ) ) PUNCT bam-8931 118 23 had have VERB bam-8931 118 24 greater great ADJ bam-8931 118 25 values value NOUN bam-8931 118 26 ( ( PUNCT bam-8931 118 27 without without ADP bam-8931 118 28 statistically statistically ADJ bam-8931 118 29 significance significance NOUN bam-8931 118 30 ) ) PUNCT bam-8931 118 31 for for ADP bam-8931 118 32 patients patient NOUN bam-8931 118 33 than than ADP bam-8931 118 34 controls control NOUN bam-8931 118 35 , , PUNCT bam-8931 118 36 both both CCONJ bam-8931 118 37 in in ADP bam-8931 118 38 knee knee NOUN bam-8931 118 39 and and CCONJ bam-8931 118 40 handgrip handgrip VERB bam-8931 118 41 tasks task NOUN bam-8931 118 42 ( ( PUNCT bam-8931 118 43 patients patient NOUN bam-8931 118 44 : : PUNCT bam-8931 118 45 -27.84 -27.84 PROPN bam-8931 118 46 ± ± NUM bam-8931 118 47 19.45 19.45 NUM bam-8931 118 48 % % NOUN bam-8931 118 49 mvc/60s mvc/60s NOUN bam-8931 118 50 , , PUNCT bam-8931 118 51 controls control VERB bam-8931 118 52 : : PUNCT bam-8931 118 53 -16.29 -16.29 PROPN bam-8931 118 54 ± ± NUM bam-8931 118 55 19.02 19.02 NUM bam-8931 118 56 % % NOUN bam-8931 118 57 mvc/60s mvc/60s NOUN bam-8931 118 58 for for ADP bam-8931 118 59 knee knee NOUN bam-8931 118 60 task task NOUN bam-8931 118 61 ; ; PUNCT bam-8931 118 62 patients patient NOUN bam-8931 118 63 : : PUNCT bam-8931 118 64 -29.93 -29.93 PROPN bam-8931 118 65 ± ± NUM bam-8931 118 66 15.62 15.62 NUM bam-8931 118 67 % % NOUN bam-8931 118 68 mvc/60s mvc/60s NOUN bam-8931 118 69 , , PUNCT bam-8931 118 70 controls control VERB bam-8931 118 71 : : PUNCT bam-8931 118 72 -25.59 -25.59 PROPN bam-8931 118 73 ± ± NUM bam-8931 118 74 11.64 11.64 NUM bam-8931 118 75 % % NOUN bam-8931 118 76 mvc/60s mvc/60s NOUN bam-8931 118 77 for for ADP bam-8931 118 78 handgrip handgrip NOUN bam-8931 118 79 task task PROPN bam-8931 118 80 ) ) PUNCT bam-8931 118 81 ( ( PUNCT bam-8931 118 82 figure figure NOUN bam-8931 118 83 4a 4a NUM bam-8931 118 84 ) ) PUNCT bam-8931 118 85 . . PUNCT bam-8931 119 1 the the DET bam-8931 119 2 ∆ ∆ PROPN bam-8931 119 3 parameter parameter NOUN bam-8931 119 4 highlight highlight VERB bam-8931 119 5 that that SCONJ bam-8931 119 6 patients patient NOUN bam-8931 119 7 and and CCONJ bam-8931 119 8 controls control NOUN bam-8931 119 9 presented present VERB bam-8931 119 10 comparable comparable ADJ bam-8931 119 11 values value NOUN bam-8931 119 12 both both CCONJ bam-8931 119 13 for for ADP bam-8931 119 14 knee knee NOUN bam-8931 119 15 task task NOUN bam-8931 119 16 ( ( PUNCT bam-8931 119 17 patients patient NOUN bam-8931 119 18 : : PUNCT bam-8931 119 19 14.57 14.57 NUM bam-8931 119 20 ± ± NUM bam-8931 119 21 9.12 9.12 NUM bam-8931 119 22 , , PUNCT bam-8931 119 23 controls control VERB bam-8931 119 24 : : PUNCT bam-8931 119 25 16.90 16.90 NUM bam-8931 119 26 ± ± NUM bam-8931 119 27 10.23 10.23 NUM bam-8931 119 28 ) ) PUNCT bam-8931 119 29 and and CCONJ bam-8931 119 30 handgrip handgrip VERB bam-8931 119 31 task task PROPN bam-8931 119 32 ( ( PUNCT bam-8931 119 33 patients patient NOUN bam-8931 119 34 : : PUNCT bam-8931 119 35 13.03 13.03 NUM bam-8931 119 36 ± ± NUM bam-8931 119 37 8.56 8.56 NUM bam-8931 119 38 , , PUNCT bam-8931 119 39 controls control VERB bam-8931 119 40 : : PUNCT bam-8931 119 41 11.89 11.89 NUM bam-8931 119 42 ± ± NUM bam-8931 119 43 10.44 10.44 NUM bam-8931 119 44 ) ) PUNCT bam-8931 119 45 ( ( PUNCT bam-8931 119 46 figure figure VERB bam-8931 119 47 4b 4b PROPN bam-8931 119 48 ) ) PUNCT bam-8931 119 49 . . PUNCT bam-8931 120 1 discussion discussion NOUN bam-8931 120 2 this this DET bam-8931 120 3 study study NOUN bam-8931 120 4 shows show VERB bam-8931 120 5 that that SCONJ bam-8931 120 6 cancer cancer NOUN bam-8931 120 7 patients patient NOUN bam-8931 120 8 have have VERB bam-8931 120 9 a a DET bam-8931 120 10 decreased decrease VERB bam-8931 120 11 muscle muscle NOUN bam-8931 120 12 efficiency efficiency NOUN bam-8931 120 13 . . PUNCT bam-8931 121 1 they they PRON bam-8931 121 2 performed perform VERB bam-8931 121 3 15.7 15.7 NUM bam-8931 121 4 minutes minute NOUN bam-8931 121 5 of of ADP bam-8931 121 6 treadmill treadmill NOUN bam-8931 121 7 walking walk VERB bam-8931 121 8 while while SCONJ bam-8931 121 9 controls control VERB bam-8931 121 10 19.6 19.6 NUM bam-8931 121 11 minutes minute NOUN bam-8931 121 12 . . PUNCT bam-8931 122 1 this this DET bam-8931 122 2 functional functional ADJ bam-8931 122 3 discrepancy discrepancy NOUN bam-8931 122 4 is be AUX bam-8931 122 5 known know VERB bam-8931 122 6 from from ADP bam-8931 122 7 literature literature NOUN bam-8931 122 8 reporting report VERB bam-8931 122 9 a a DET bam-8931 122 10 significant significant ADJ bam-8931 122 11 decline decline NOUN bam-8931 122 12 of of ADP bam-8931 122 13 spontaneous spontaneous ADJ bam-8931 122 14 physical physical ADJ bam-8931 122 15 activity activity NOUN bam-8931 122 16 and and CCONJ bam-8931 122 17 weight weight NOUN bam-8931 122 18 in in ADP bam-8931 122 19 cancer cancer NOUN bam-8931 122 20 patients patient NOUN bam-8931 122 21 , , PUNCT bam-8931 122 22 related relate VERB bam-8931 122 23 to to ADP bam-8931 122 24 disease disease NOUN bam-8931 122 25 progression.33 progression.33 NOUN bam-8931 122 26 however however ADV bam-8931 122 27 , , PUNCT bam-8931 122 28 in in ADP bam-8931 122 29 our our PRON bam-8931 122 30 patients patient NOUN bam-8931 122 31 , , PUNCT bam-8931 122 32 a a DET bam-8931 122 33 significant significant ADJ bam-8931 122 34 weight weight NOUN bam-8931 122 35 loss loss NOUN bam-8931 122 36 was be AUX bam-8931 122 37 not not PART bam-8931 122 38 observed observe VERB bam-8931 122 39 . . PUNCT bam-8931 123 1 moreover moreover ADV bam-8931 123 2 , , PUNCT bam-8931 123 3 considering consider VERB bam-8931 123 4 the the DET bam-8931 123 5 patient patient NOUN bam-8931 123 6 group group NOUN bam-8931 123 7 , , PUNCT bam-8931 123 8 we we PRON bam-8931 123 9 observed observe VERB bam-8931 123 10 a a DET bam-8931 123 11 muscle muscle NOUN bam-8931 123 12 strength strength NOUN bam-8931 123 13 reduction reduction NOUN bam-8931 123 14 both both CCONJ bam-8931 123 15 in in ADP bam-8931 123 16 knee knee NOUN bam-8931 123 17 extension extension NOUN bam-8931 123 18 and and CCONJ bam-8931 123 19 handgrip handgrip NOUN bam-8931 123 20 performance performance NOUN bam-8931 123 21 and and CCONJ bam-8931 123 22 increased increase VERB bam-8931 123 23 muscle muscle NOUN bam-8931 123 24 fatigue fatigue NOUN bam-8931 123 25 compared compare VERB bam-8931 123 26 to to ADP bam-8931 123 27 controls control NOUN bam-8931 123 28 . . PUNCT bam-8931 124 1 it it PRON bam-8931 124 2 is be AUX bam-8931 124 3 known know VERB bam-8931 124 4 that that SCONJ bam-8931 124 5 skeletal skeletal ADJ bam-8931 124 6 muscle muscle NOUN bam-8931 124 7 wasting waste VERB bam-8931 124 8 and and CCONJ bam-8931 124 9 impaired impaired ADJ bam-8931 124 10 muscle muscle NOUN bam-8931 124 11 performance performance NOUN bam-8931 124 12 are be AUX bam-8931 124 13 prominent prominent ADJ bam-8931 124 14 pathophysiological pathophysiological ADJ bam-8931 124 15 features feature NOUN bam-8931 124 16 of of ADP bam-8931 124 17 cc cc PROPN bam-8931 124 18 . . PROPN bam-8931 124 19 tumour tumour NOUN bam-8931 124 20 - - PUNCT bam-8931 124 21 bearing bear VERB bam-8931 124 22 animals animal NOUN bam-8931 124 23 and and CCONJ bam-8931 124 24 cancer cancer NOUN bam-8931 124 25 patients patient NOUN bam-8931 124 26 display display VERB bam-8931 124 27 wasting waste VERB bam-8931 124 28 , , PUNCT bam-8931 124 29 impaired impaired ADJ bam-8931 124 30 muscle muscle NOUN bam-8931 124 31 force force NOUN bam-8931 124 32 production production NOUN bam-8931 124 33 and and CCONJ bam-8931 124 34 acceleration acceleration NOUN bam-8931 124 35 onset onset NOUN bam-8931 124 36 of of ADP bam-8931 124 37 fatigue.34 fatigue.34 NOUN bam-8931 124 38 - - PUNCT bam-8931 124 39 35 35 NUM bam-8931 124 40 even even ADV bam-8931 124 41 if if SCONJ bam-8931 124 42 our our PRON bam-8931 124 43 results result NOUN bam-8931 124 44 are be AUX bam-8931 124 45 not not PART bam-8931 124 46 statistically statistically ADV bam-8931 124 47 significant significant ADJ bam-8931 124 48 , , PUNCT bam-8931 124 49 the the DET bam-8931 124 50 relevance relevance NOUN bam-8931 124 51 of of ADP bam-8931 124 52 the the DET bam-8931 124 53 study study NOUN bam-8931 124 54 is be AUX bam-8931 124 55 that that SCONJ bam-8931 124 56 our our PRON bam-8931 124 57 data datum NOUN bam-8931 124 58 were be AUX bam-8931 124 59 obtained obtain VERB bam-8931 124 60 on on ADP bam-8931 124 61 cancer cancer NOUN bam-8931 124 62 patients patient NOUN bam-8931 124 63 who who PRON bam-8931 124 64 had have VERB bam-8931 124 65 no no DET bam-8931 124 66 cachexia cachexia NOUN bam-8931 124 67 nor nor CCONJ bam-8931 124 68 pre pre ADJ bam-8931 124 69 - - ADJ bam-8931 124 70 cachexia cachexia ADJ bam-8931 124 71 and and CCONJ bam-8931 124 72 without without ADP bam-8931 124 73 any any DET bam-8931 124 74 limitation limitation NOUN bam-8931 124 75 in in ADP bam-8931 124 76 daily daily ADJ bam-8931 124 77 living living NOUN bam-8931 124 78 activities activity NOUN bam-8931 124 79 . . PUNCT bam-8931 125 1 furthermore furthermore ADV bam-8931 125 2 , , PUNCT bam-8931 125 3 we we PRON bam-8931 125 4 highlighted highlight VERB bam-8931 125 5 an an DET bam-8931 125 6 evidence evidence NOUN bam-8931 125 7 of of ADP bam-8931 125 8 early early ADJ bam-8931 125 9 - - PUNCT bam-8931 125 10 impaired impair VERB bam-8931 125 11 muscle muscle NOUN bam-8931 125 12 performance performance NOUN bam-8931 125 13 in in ADP bam-8931 125 14 patients patient NOUN bam-8931 125 15 , , PUNCT bam-8931 125 16 who who PRON bam-8931 125 17 did do AUX bam-8931 125 18 not not PART bam-8931 125 19 show show VERB bam-8931 125 20 any any DET bam-8931 125 21 weight weight NOUN bam-8931 125 22 loss loss NOUN bam-8931 125 23 or or CCONJ bam-8931 125 24 muscle muscle NOUN bam-8931 125 25 wasting waste VERB bam-8931 125 26 , , PUNCT bam-8931 125 27 but but CCONJ bam-8931 125 28 which which PRON bam-8931 125 29 have have VERB bam-8931 125 30 a a DET bam-8931 125 31 very very ADV bam-8931 125 32 similar similar ADJ bam-8931 125 33 trend trend NOUN bam-8931 125 34 as as SCONJ bam-8931 125 35 regards regard VERB bam-8931 125 36 the the DET bam-8931 125 37 progressive progressive ADJ bam-8931 125 38 decline decline NOUN bam-8931 125 39 of of ADP bam-8931 125 40 muscle muscle NOUN bam-8931 125 41 strength strength NOUN bam-8931 125 42 and and CCONJ bam-8931 125 43 the the DET bam-8931 125 44 earlier early ADJ bam-8931 125 45 onset onset NOUN bam-8931 125 46 of of ADP bam-8931 125 47 fatigue fatigue NOUN bam-8931 125 48 as as SCONJ bam-8931 125 49 occurs occur VERB bam-8931 125 50 in in ADP bam-8931 125 51 cc cc PROPN bam-8931 125 52 . . PUNCT bam-8931 126 1 the the DET bam-8931 126 2 relevance relevance NOUN bam-8931 126 3 of of ADP bam-8931 126 4 muscle muscle NOUN bam-8931 126 5 fatigue fatigue NOUN bam-8931 126 6 in in ADP bam-8931 126 7 cc cc PROPN bam-8931 126 8 is be AUX bam-8931 126 9 well well ADV bam-8931 126 10 established establish VERB bam-8931 126 11 : : PUNCT bam-8931 126 12 in in ADP bam-8931 126 13 fact fact NOUN bam-8931 126 14 fatigue fatigue NOUN bam-8931 126 15 is be AUX bam-8931 126 16 the the DET bam-8931 126 17 most most ADV bam-8931 126 18 frequently frequently ADV bam-8931 126 19 reported report VERB bam-8931 126 20 symptom symptom NOUN bam-8931 126 21 by by ADP bam-8931 126 22 cancer cancer NOUN bam-8931 126 23 patients patient NOUN bam-8931 126 24 . . PUNCT bam-8931 127 1 many many ADJ bam-8931 127 2 of of ADP bam-8931 127 3 these these DET bam-8931 127 4 patients patient NOUN bam-8931 127 5 perceive perceive VERB bam-8931 127 6 fatigue fatigue NOUN bam-8931 127 7 as as ADP bam-8931 127 8 the the DET bam-8931 127 9 most most ADV bam-8931 127 10 distressing distressing ADJ bam-8931 127 11 symptom symptom NOUN bam-8931 127 12 associated associate VERB bam-8931 127 13 with with ADP bam-8931 127 14 their their PRON bam-8931 127 15 illness illness NOUN bam-8931 127 16 because because SCONJ bam-8931 127 17 it it PRON bam-8931 127 18 imposes impose VERB bam-8931 127 19 limitations limitation NOUN bam-8931 127 20 on on ADP bam-8931 127 21 their their PRON bam-8931 127 22 physical physical ADJ bam-8931 127 23 activity activity NOUN bam-8931 127 24 level level NOUN bam-8931 127 25 and and CCONJ bam-8931 127 26 in in ADP bam-8931 127 27 lifestyle.36 lifestyle.36 VERB bam-8931 127 28 skeletal skeletal ADJ bam-8931 127 29 muscle muscle NOUN bam-8931 127 30 wasting wasting NOUN bam-8931 127 31 , , PUNCT bam-8931 127 32 which which PRON bam-8931 127 33 occurs occur VERB bam-8931 127 34 as as ADP bam-8931 127 35 part part NOUN bam-8931 127 36 of of ADP bam-8931 127 37 cc cc PROPN bam-8931 127 38 , , PUNCT bam-8931 127 39 is be AUX bam-8931 127 40 one one NUM bam-8931 127 41 of of ADP bam-8931 127 42 the the DET bam-8931 127 43 mechanisms mechanism NOUN bam-8931 127 44 that that PRON bam-8931 127 45 contribute contribute VERB bam-8931 127 46 to to ADP bam-8931 127 47 fatigue.35 fatigue.35 NOUN bam-8931 127 48 patients patient NOUN bam-8931 127 49 enrolled enrol VERB bam-8931 127 50 in in ADP bam-8931 127 51 our our PRON bam-8931 127 52 study study NOUN bam-8931 127 53 did do AUX bam-8931 127 54 not not PART bam-8931 127 55 report report VERB bam-8931 127 56 fatigue fatigue NOUN bam-8931 127 57 as as ADP bam-8931 127 58 one one NUM bam-8931 127 59 of of ADP bam-8931 127 60 the the DET bam-8931 127 61 prominent prominent ADJ bam-8931 127 62 symptoms symptom NOUN bam-8931 127 63 of of ADP bam-8931 127 64 the the DET bam-8931 127 65 disease disease NOUN bam-8931 127 66 and and CCONJ bam-8931 127 67 did do AUX bam-8931 127 68 not not PART bam-8931 127 69 report report VERB bam-8931 127 70 significant significant ADJ bam-8931 127 71 limitations limitation NOUN bam-8931 127 72 in in ADP bam-8931 127 73 their their PRON bam-8931 127 74 daily daily ADJ bam-8931 127 75 living living NOUN bam-8931 127 76 activities activity NOUN bam-8931 127 77 . . PUNCT bam-8931 128 1 however however ADV bam-8931 128 2 , , PUNCT bam-8931 128 3 more more ADV bam-8931 128 4 recently recently ADV bam-8931 128 5 , , PUNCT bam-8931 128 6 roberts roberts PROPN bam-8931 128 7 and and CCONJ bam-8931 128 8 colleagues,37 colleagues,37 VERB bam-8931 128 9 provided provide VERB bam-8931 128 10 evidence evidence NOUN bam-8931 128 11 that that SCONJ bam-8931 128 12 during during ADP bam-8931 128 13 severe severe ADJ bam-8931 128 14 cc cc NOUN bam-8931 128 15 muscle muscle NOUN bam-8931 128 16 weakness weakness NOUN bam-8931 128 17 in in ADP bam-8931 128 18 limb limb NOUN bam-8931 128 19 muscle muscle NOUN bam-8931 128 20 can can AUX bam-8931 128 21 not not PART bam-8931 128 22 be be AUX bam-8931 128 23 entirely entirely ADV bam-8931 128 24 accounted account VERB bam-8931 128 25 for for ADP bam-8931 128 26 muscle muscle NOUN bam-8931 128 27 atrophy atrophy NOUN bam-8931 128 28 . . PUNCT bam-8931 129 1 this this PRON bam-8931 129 2 indicates indicate VERB bam-8931 129 3 that that SCONJ bam-8931 129 4 muscle muscle NOUN bam-8931 129 5 weakness weakness NOUN bam-8931 129 6 is be AUX bam-8931 129 7 not not PART bam-8931 129 8 just just ADV bam-8931 129 9 a a DET bam-8931 129 10 consequence consequence NOUN bam-8931 129 11 of of ADP bam-8931 129 12 muscle muscle NOUN bam-8931 129 13 atrophy atrophy NOUN bam-8931 129 14 but but CCONJ bam-8931 129 15 that that SCONJ bam-8931 129 16 there there PRON bam-8931 129 17 is be VERB bam-8931 129 18 also also ADV bam-8931 129 19 significant significant ADJ bam-8931 129 20 contractile contractile NOUN bam-8931 129 21 dysfunction dysfunction NOUN bam-8931 129 22 . . PUNCT bam-8931 130 1 they they PRON bam-8931 130 2 also also ADV bam-8931 130 3 suggested suggest VERB bam-8931 130 4 that that SCONJ bam-8931 130 5 specifically specifically ADV bam-8931 130 6 targeting target VERB bam-8931 130 7 contractile contractile NOUN bam-8931 130 8 dysfunction dysfunction NOUN bam-8931 130 9 represents represent VERB bam-8931 130 10 an an DET bam-8931 130 11 additional additional ADJ bam-8931 130 12 means mean NOUN bam-8931 130 13 to to PART bam-8931 130 14 counteract counteract VERB bam-8931 130 15 muscle muscle NOUN bam-8931 130 16 weakness weakness NOUN bam-8931 130 17 in in ADP bam-8931 130 18 cc cc PROPN bam-8931 130 19 , , PUNCT bam-8931 130 20 in in ADP bam-8931 130 21 addition addition NOUN bam-8931 130 22 to to ADP bam-8931 130 23 targeting target VERB bam-8931 130 24 the the DET bam-8931 130 25 fig fig NOUN bam-8931 130 26 4 4 NUM bam-8931 130 27 . . PUNCT bam-8931 131 1 a a DET bam-8931 131 2 : : PUNCT bam-8931 131 3 box box NOUN bam-8931 131 4 plot plot NOUN bam-8931 131 5 of of ADP bam-8931 131 6 muscle muscle NOUN bam-8931 131 7 fatigue fatigue NOUN bam-8931 131 8 parameter parameter NOUN bam-8931 131 9 ( ( PUNCT bam-8931 131 10 % % INTJ bam-8931 131 11 mvc mvc NOUN bam-8931 131 12 / / SYM bam-8931 131 13 60 60 NUM bam-8931 131 14 s s NOUN bam-8931 131 15 ) ) PUNCT bam-8931 131 16 for for ADP bam-8931 131 17 patients patient NOUN bam-8931 131 18 and and CCONJ bam-8931 131 19 healthy healthy ADJ bam-8931 131 20 subjects subject NOUN bam-8931 131 21 . . PUNCT bam-8931 132 1 top top ADJ bam-8931 132 2 panel panel NOUN bam-8931 132 3 : : PUNCT bam-8931 132 4 knee knee NOUN bam-8931 132 5 extension extension NOUN bam-8931 132 6 . . PUNCT bam-8931 133 1 bottom bottom ADJ bam-8931 133 2 panel panel NOUN bam-8931 133 3 : : PUNCT bam-8931 133 4 handgrip handgrip NOUN bam-8931 133 5 . . PUNCT bam-8931 134 1 b b X bam-8931 134 2 : : PUNCT bam-8931 134 3 mean mean VERB bam-8931 134 4 and and CCONJ bam-8931 134 5 one one NUM bam-8931 134 6 standard standard ADJ bam-8931 134 7 deviation deviation NOUN bam-8931 134 8 of of ADP bam-8931 134 9 difference difference NOUN bam-8931 134 10 , , PUNCT bam-8931 134 11 in in ADP bam-8931 134 12 term term NOUN bam-8931 134 13 of of ADP bam-8931 134 14 voluntary voluntary ADJ bam-8931 134 15 contraction contraction NOUN bam-8931 134 16 normalized normalize VERB bam-8931 134 17 by by ADP bam-8931 134 18 maximal maximal ADJ bam-8931 134 19 voluntary voluntary ADJ bam-8931 134 20 contraction contraction NOUN bam-8931 134 21 , , PUNCT bam-8931 134 22 between between ADP bam-8931 134 23 last last ADJ bam-8931 134 24 3 3 NUM bam-8931 134 25 s s NOUN bam-8931 134 26 of of ADP bam-8931 134 27 the the DET bam-8931 134 28 endurance endurance NOUN bam-8931 134 29 trial trial NOUN bam-8931 134 30 and and CCONJ bam-8931 134 31 the the DET bam-8931 134 32 3 3 NUM bam-8931 134 33 s s NOUN bam-8931 134 34 after after ADP bam-8931 134 35 a a DET bam-8931 134 36 short short ADJ bam-8931 134 37 time time NOUN bam-8931 134 38 ( ( PUNCT bam-8931 134 39 20 20 NUM bam-8931 134 40 s s NOUN bam-8931 134 41 ) ) PUNCT bam-8931 134 42 of of ADP bam-8931 134 43 rest rest NOUN bam-8931 134 44 , , PUNCT bam-8931 134 45 for for ADP bam-8931 134 46 patients patient NOUN bam-8931 134 47 ( ( PUNCT bam-8931 134 48 black black ADJ bam-8931 134 49 ) ) PUNCT bam-8931 134 50 and and CCONJ bam-8931 134 51 healthy healthy ADJ bam-8931 134 52 subjects subject NOUN bam-8931 134 53 ( ( PUNCT bam-8931 134 54 grey grey PROPN bam-8931 134 55 ) ) PUNCT bam-8931 134 56 . . PUNCT bam-8931 135 1 top top ADJ bam-8931 135 2 panel panel NOUN bam-8931 135 3 : : PUNCT bam-8931 135 4 knee knee NOUN bam-8931 135 5 extension extension NOUN bam-8931 135 6 . . PUNCT bam-8931 136 1 bottom bottom ADJ bam-8931 136 2 panel panel NOUN bam-8931 136 3 : : PUNCT bam-8931 136 4 handgrip handgrip NOUN bam-8931 136 5 . . PUNCT bam-8931 137 1 muscle muscle NOUN bam-8931 137 2 impairment impairment NOUN bam-8931 137 3 in in ADP bam-8931 137 4 pre pre ADJ bam-8931 137 5 - - ADJ bam-8931 137 6 cachexia cachexia ADJ bam-8931 137 7 cancer cancer NOUN bam-8931 137 8 patients patient NOUN bam-8931 137 9 eur eur PROPN bam-8931 137 10 j j PROPN bam-8931 137 11 transl transl PROPN bam-8931 137 12 myol myol ADV bam-8931 137 13 30 30 NUM bam-8931 137 14 ( ( PUNCT bam-8931 137 15 2 2 NUM bam-8931 137 16 ): ): PUNCT bam-8931 137 17 258 258 NUM bam-8931 137 18 - - SYM bam-8931 137 19 267 267 NUM bam-8931 137 20 , , PUNCT bam-8931 137 21 2020 2020 NUM bam-8931 137 22 264 264 NUM bam-8931 137 23 prevention prevention NOUN bam-8931 137 24 of of ADP bam-8931 137 25 muscle muscle NOUN bam-8931 137 26 atrophy atrophy NOUN bam-8931 137 27 . . PUNCT bam-8931 138 1 according accord VERB bam-8931 138 2 to to ADP bam-8931 138 3 these these DET bam-8931 138 4 findings finding NOUN bam-8931 138 5 , , PUNCT bam-8931 138 6 we we PRON bam-8931 138 7 can can AUX bam-8931 138 8 assume assume VERB bam-8931 138 9 that that SCONJ bam-8931 138 10 in in ADP bam-8931 138 11 our our PRON bam-8931 138 12 patients patient NOUN bam-8931 138 13 ( ( PUNCT bam-8931 138 14 nonexhibiting nonexhibite VERB bam-8931 138 15 muscle muscle NOUN bam-8931 138 16 wasting wasting NOUN bam-8931 138 17 ) ) PUNCT bam-8931 138 18 a a DET bam-8931 138 19 contractile contractile NOUN bam-8931 138 20 dysfunction dysfunction NOUN bam-8931 138 21 may may AUX bam-8931 138 22 be be AUX bam-8931 138 23 one one NUM bam-8931 138 24 of of ADP bam-8931 138 25 the the DET bam-8931 138 26 mechanisms mechanism NOUN bam-8931 138 27 involved involve VERB bam-8931 138 28 in in ADP bam-8931 138 29 impaired impaired ADJ bam-8931 138 30 muscle muscle NOUN bam-8931 138 31 performance performance NOUN bam-8931 138 32 . . PUNCT bam-8931 139 1 if if SCONJ bam-8931 139 2 true true ADJ bam-8931 139 3 , , PUNCT bam-8931 139 4 we we PRON bam-8931 139 5 could could AUX bam-8931 139 6 think think VERB bam-8931 139 7 to to PART bam-8931 139 8 design design VERB bam-8931 139 9 specific specific ADJ bam-8931 139 10 rehabilitative rehabilitative ADJ bam-8931 139 11 treatments treatment NOUN bam-8931 139 12 , , PUNCT bam-8931 139 13 such such ADJ bam-8931 139 14 as as ADP bam-8931 139 15 endurance endurance ADJ bam-8931 139 16 exercise exercise NOUN bam-8931 139 17 , , PUNCT bam-8931 139 18 to to PART bam-8931 139 19 counteract counteract VERB bam-8931 139 20 cancer cancer NOUN bam-8931 139 21 - - PUNCT bam-8931 139 22 related relate VERB bam-8931 139 23 fatigue fatigue NOUN bam-8931 139 24 , , PUNCT bam-8931 139 25 as as SCONJ bam-8931 139 26 highlighted highlight VERB bam-8931 139 27 in in ADP bam-8931 139 28 many many ADJ bam-8931 139 29 evidence.38 evidence.38 PROPN bam-8931 139 30 - - PUNCT bam-8931 139 31 39 39 NUM bam-8931 139 32 as as ADP bam-8931 139 33 regard regard NOUN bam-8931 139 34 muscle muscle NOUN bam-8931 139 35 recovery recovery NOUN bam-8931 139 36 , , PUNCT bam-8931 139 37 we we PRON bam-8931 139 38 observed observe VERB bam-8931 139 39 a a DET bam-8931 139 40 similar similar ADJ bam-8931 139 41 trend trend NOUN bam-8931 139 42 in in ADP bam-8931 139 43 the the DET bam-8931 139 44 two two NUM bam-8931 139 45 groups group NOUN bam-8931 139 46 . . PUNCT bam-8931 140 1 analysis analysis NOUN bam-8931 140 2 of of ADP bam-8931 140 3 this this DET bam-8931 140 4 result result NOUN bam-8931 140 5 must must AUX bam-8931 140 6 take take VERB bam-8931 140 7 into into ADP bam-8931 140 8 account account NOUN bam-8931 140 9 that that SCONJ bam-8931 140 10 maximal maximal ADJ bam-8931 140 11 contractions contraction NOUN bam-8931 140 12 used use VERB bam-8931 140 13 in in ADP bam-8931 140 14 the the DET bam-8931 140 15 present present ADJ bam-8931 140 16 study study NOUN bam-8931 140 17 depended depend VERB bam-8931 140 18 primarily primarily ADV bam-8931 140 19 on on ADP bam-8931 140 20 anaerobic anaerobic ADJ bam-8931 140 21 metabolism metabolism NOUN bam-8931 140 22 , , PUNCT bam-8931 140 23 so so SCONJ bam-8931 140 24 we we PRON bam-8931 140 25 can can AUX bam-8931 140 26 assume assume VERB bam-8931 140 27 that that SCONJ bam-8931 140 28 in in ADP bam-8931 140 29 these these DET bam-8931 140 30 patients patient NOUN bam-8931 140 31 this this DET bam-8931 140 32 metabolic metabolic NOUN bam-8931 140 33 pathway pathway NOUN bam-8931 140 34 is be AUX bam-8931 140 35 not not PART bam-8931 140 36 affected affect VERB bam-8931 140 37 . . PUNCT bam-8931 141 1 on on ADP bam-8931 141 2 the the DET bam-8931 141 3 other other ADJ bam-8931 141 4 hand hand NOUN bam-8931 141 5 , , PUNCT bam-8931 141 6 another another DET bam-8931 141 7 interesting interesting ADJ bam-8931 141 8 aspect aspect NOUN bam-8931 141 9 investigated investigate VERB bam-8931 141 10 in in ADP bam-8931 141 11 this this DET bam-8931 141 12 study study NOUN bam-8931 141 13 was be AUX bam-8931 141 14 the the DET bam-8931 141 15 efficiency efficiency NOUN bam-8931 141 16 of of ADP bam-8931 141 17 the the DET bam-8931 141 18 aerobic aerobic ADJ bam-8931 141 19 metabolism metabolism NOUN bam-8931 141 20 of of ADP bam-8931 141 21 cancer cancer NOUN bam-8931 141 22 patient patient NOUN bam-8931 141 23 ’s ’s PART bam-8931 141 24 muscle muscle NOUN bam-8931 141 25 . . PUNCT bam-8931 142 1 analysis analysis NOUN bam-8931 142 2 of of ADP bam-8931 142 3 blood blood NOUN bam-8931 142 4 lactate lactate NOUN bam-8931 142 5 levels level NOUN bam-8931 142 6 showed show VERB bam-8931 142 7 significantly significantly ADV bam-8931 142 8 higher high ADJ bam-8931 142 9 values value NOUN bam-8931 142 10 both both CCONJ bam-8931 142 11 at at ADP bam-8931 142 12 rest rest NOUN bam-8931 142 13 and and CCONJ bam-8931 142 14 in in ADP bam-8931 142 15 the the DET bam-8931 142 16 recovery recovery NOUN bam-8931 142 17 period period NOUN bam-8931 142 18 in in ADP bam-8931 142 19 our our PRON bam-8931 142 20 subjects subject NOUN bam-8931 142 21 . . PUNCT bam-8931 143 1 this this DET bam-8931 143 2 finding finding NOUN bam-8931 143 3 suggests suggest VERB bam-8931 143 4 a a DET bam-8931 143 5 reduction reduction NOUN bam-8931 143 6 of of ADP bam-8931 143 7 the the DET bam-8931 143 8 oxidative oxidative ADJ bam-8931 143 9 muscle muscle NOUN bam-8931 143 10 efficiency efficiency NOUN bam-8931 143 11 and and CCONJ bam-8931 143 12 a a DET bam-8931 143 13 precocious precocious ADJ bam-8931 143 14 resort resort NOUN bam-8931 143 15 to to ADP bam-8931 143 16 the the DET bam-8931 143 17 anaerobic anaerobic ADJ bam-8931 143 18 metabolism metabolism NOUN bam-8931 143 19 in in ADP bam-8931 143 20 these these DET bam-8931 143 21 patients patient NOUN bam-8931 143 22 . . PUNCT bam-8931 144 1 it it PRON bam-8931 144 2 is be AUX bam-8931 144 3 well well ADV bam-8931 144 4 established establish VERB bam-8931 144 5 that that SCONJ bam-8931 144 6 , , PUNCT bam-8931 144 7 during during ADP bam-8931 144 8 an an DET bam-8931 144 9 aerobic aerobic ADJ bam-8931 144 10 prolonged prolonged ADJ bam-8931 144 11 exercise exercise NOUN bam-8931 144 12 , , PUNCT bam-8931 144 13 lactate lactate NOUN bam-8931 144 14 concentration concentration NOUN bam-8931 144 15 lightly lightly ADV bam-8931 144 16 increases increase VERB bam-8931 144 17 in in ADP bam-8931 144 18 blood blood NOUN bam-8931 144 19 . . PUNCT bam-8931 145 1 if if SCONJ bam-8931 145 2 the the DET bam-8931 145 3 oxidative oxidative ADJ bam-8931 145 4 metabolism metabolism NOUN bam-8931 145 5 becomes become VERB bam-8931 145 6 insufficient insufficient ADJ bam-8931 145 7 , , PUNCT bam-8931 145 8 the the DET bam-8931 145 9 energy energy NOUN bam-8931 145 10 output output NOUN bam-8931 145 11 is be AUX bam-8931 145 12 guaranteed guarantee VERB bam-8931 145 13 by by ADP bam-8931 145 14 anaerobic anaerobic ADJ bam-8931 145 15 metabolism metabolism NOUN bam-8931 145 16 supplementation supplementation NOUN bam-8931 145 17 , , PUNCT bam-8931 145 18 and and CCONJ bam-8931 145 19 in in ADP bam-8931 145 20 this this DET bam-8931 145 21 condition condition NOUN bam-8931 145 22 , , PUNCT bam-8931 145 23 lactate lactate NOUN bam-8931 145 24 accumulates accumulate VERB bam-8931 145 25 in in ADP bam-8931 145 26 the the DET bam-8931 145 27 blood.40 blood.40 NOUN bam-8931 145 28 this this DET bam-8931 145 29 functional functional ADJ bam-8931 145 30 evidence evidence NOUN bam-8931 145 31 , , PUNCT bam-8931 145 32 observed observe VERB bam-8931 145 33 in in ADP bam-8931 145 34 our our PRON bam-8931 145 35 patients patient NOUN bam-8931 145 36 , , PUNCT bam-8931 145 37 is be AUX bam-8931 145 38 in in ADP bam-8931 145 39 accordance accordance NOUN bam-8931 145 40 with with ADP bam-8931 145 41 literature literature NOUN bam-8931 145 42 . . PUNCT bam-8931 146 1 actually actually ADV bam-8931 146 2 , , PUNCT bam-8931 146 3 in in ADP bam-8931 146 4 a a DET bam-8931 146 5 recent recent ADJ bam-8931 146 6 study,41 study,41 PROPN bam-8931 146 7 adenosine adenosine NOUN bam-8931 146 8 triphosphate triphosphate NOUN bam-8931 146 9 ( ( PUNCT bam-8931 146 10 atp atp NOUN bam-8931 146 11 ) ) PUNCT bam-8931 146 12 synthesis synthesis NOUN bam-8931 146 13 rate rate NOUN bam-8931 146 14 and and CCONJ bam-8931 146 15 the the DET bam-8931 146 16 expression expression NOUN bam-8931 146 17 of of ADP bam-8931 146 18 genes gene NOUN bam-8931 146 19 that that PRON bam-8931 146 20 play play VERB bam-8931 146 21 key key ADJ bam-8931 146 22 regulatory regulatory ADJ bam-8931 146 23 roles role NOUN bam-8931 146 24 in in ADP bam-8931 146 25 skeletal skeletal ADJ bam-8931 146 26 muscle muscle NOUN bam-8931 146 27 metabolism metabolism NOUN bam-8931 146 28 was be AUX bam-8931 146 29 examined examine VERB bam-8931 146 30 in in ADP bam-8931 146 31 tumor tumor NOUN bam-8931 146 32 - - PUNCT bam-8931 146 33 bearing bear VERB bam-8931 146 34 mice mouse NOUN bam-8931 146 35 by by ADP bam-8931 146 36 in in ADP bam-8931 146 37 vivo vivo ADJ bam-8931 146 38 nuclear nuclear ADJ bam-8931 146 39 magnetic magnetic ADJ bam-8931 146 40 resonance resonance NOUN bam-8931 146 41 : : PUNCT bam-8931 146 42 a a DET bam-8931 146 43 reduced reduce VERB bam-8931 146 44 atp atp NOUN bam-8931 146 45 synthesis synthesis NOUN bam-8931 146 46 rate rate NOUN bam-8931 146 47 and and CCONJ bam-8931 146 48 an an DET bam-8931 146 49 atypical atypical ADJ bam-8931 146 50 expression expression NOUN bam-8931 146 51 levels level NOUN bam-8931 146 52 of of ADP bam-8931 146 53 these these DET bam-8931 146 54 genes gene NOUN bam-8931 146 55 was be AUX bam-8931 146 56 shown show VERB bam-8931 146 57 , , PUNCT bam-8931 146 58 suggesting suggest VERB bam-8931 146 59 that that SCONJ bam-8931 146 60 reduced reduce VERB bam-8931 146 61 atp atp NOUN bam-8931 146 62 synthesis synthesis NOUN bam-8931 146 63 is be AUX bam-8931 146 64 linked link VERB bam-8931 146 65 to to ADP bam-8931 146 66 mitochondrial mitochondrial ADJ bam-8931 146 67 dysfunction dysfunction NOUN bam-8931 146 68 , , PUNCT bam-8931 146 69 ultimately ultimately ADV bam-8931 146 70 leading lead VERB bam-8931 146 71 to to ADP bam-8931 146 72 skeletal skeletal ADJ bam-8931 146 73 muscle muscle NOUN bam-8931 146 74 wasting.41 wasting.41 PROPN bam-8931 146 75 recently recently ADV bam-8931 146 76 , , PUNCT bam-8931 146 77 a a DET bam-8931 146 78 correlation correlation NOUN bam-8931 146 79 between between ADP bam-8931 146 80 muscle muscle NOUN bam-8931 146 81 wasting waste VERB bam-8931 146 82 syndrome syndrome NOUN bam-8931 146 83 and and CCONJ bam-8931 146 84 mitochondrial mitochondrial ADJ bam-8931 146 85 dysfunction dysfunction NOUN bam-8931 146 86 has have AUX bam-8931 146 87 been be AUX bam-8931 146 88 demonstrated demonstrate VERB bam-8931 146 89 in in ADP bam-8931 146 90 severely severely ADV bam-8931 146 91 cachexia cachexia ADJ bam-8931 146 92 mice mouse NOUN bam-8931 146 93 . . PUNCT bam-8931 147 1 in in ADP bam-8931 147 2 particular particular ADJ bam-8931 147 3 , , PUNCT bam-8931 147 4 the the DET bam-8931 147 5 authors author NOUN bam-8931 147 6 suggested suggest VERB bam-8931 147 7 that that SCONJ bam-8931 147 8 the the DET bam-8931 147 9 expression expression NOUN bam-8931 147 10 of of ADP bam-8931 147 11 proteins protein NOUN bam-8931 147 12 regulating regulate VERB bam-8931 147 13 mitochondrial mitochondrial ADJ bam-8931 147 14 biogenesis biogenesis NOUN bam-8931 147 15 and and CCONJ bam-8931 147 16 mitochondrial mitochondrial ADJ bam-8931 147 17 dynamics dynamic NOUN bam-8931 147 18 are be AUX bam-8931 147 19 disrupted disrupt VERB bam-8931 147 20 early early ADV bam-8931 147 21 in in ADP bam-8931 147 22 the the DET bam-8931 147 23 development development NOUN bam-8931 147 24 of of ADP bam-8931 147 25 cachexia cachexia NOUN bam-8931 147 26 and and CCONJ bam-8931 147 27 precede precede VERB bam-8931 147 28 a a DET bam-8931 147 29 reduction reduction NOUN bam-8931 147 30 in in ADP bam-8931 147 31 mitochondria mitochondria PROPN bam-8931 147 32 content content NOUN bam-8931 147 33 . . PUNCT bam-8931 148 1 furthermore furthermore ADV bam-8931 148 2 , , PUNCT bam-8931 148 3 alterations alteration NOUN bam-8931 148 4 in in ADP bam-8931 148 5 the the DET bam-8931 148 6 expression expression NOUN bam-8931 148 7 of of ADP bam-8931 148 8 these these DET bam-8931 148 9 proteins protein NOUN bam-8931 148 10 are be AUX bam-8931 148 11 associated associate VERB bam-8931 148 12 with with ADP bam-8931 148 13 higher high ADJ bam-8931 148 14 levels level NOUN bam-8931 148 15 of of ADP bam-8931 148 16 circulating circulate VERB bam-8931 148 17 il-6 il-6 NOUN bam-8931 148 18 . . PUNCT bam-8931 149 1 the the DET bam-8931 149 2 protein protein NOUN bam-8931 149 3 expression expression NOUN bam-8931 149 4 was be AUX bam-8931 149 5 inhibited inhibit VERB bam-8931 149 6 by by ADP bam-8931 149 7 the the DET bam-8931 149 8 administration administration NOUN bam-8931 149 9 of of ADP bam-8931 149 10 an an DET bam-8931 149 11 il-6r il-6r ADJ bam-8931 149 12 antibody antibody NOUN bam-8931 149 13 and and CCONJ bam-8931 149 14 was be AUX bam-8931 149 15 strongly strongly ADV bam-8931 149 16 down down ADV bam-8931 149 17 - - PUNCT bam-8931 149 18 regulated regulate VERB bam-8931 149 19 by by ADP bam-8931 149 20 exercise exercise NOUN bam-8931 149 21 training.42 training.42 NOUN bam-8931 149 22 the the DET bam-8931 149 23 early early ADJ bam-8931 149 24 detection detection NOUN bam-8931 149 25 of of ADP bam-8931 149 26 oxidative oxidative ADJ bam-8931 149 27 defects defect NOUN bam-8931 149 28 in in ADP bam-8931 149 29 these these DET bam-8931 149 30 patients patient NOUN bam-8931 149 31 may may AUX bam-8931 149 32 have have VERB bam-8931 149 33 extremely extremely ADV bam-8931 149 34 important important ADJ bam-8931 149 35 therapeutic therapeutic ADJ bam-8931 149 36 implications implication NOUN bam-8931 149 37 . . PUNCT bam-8931 150 1 in in ADP bam-8931 150 2 this this DET bam-8931 150 3 regard regard NOUN bam-8931 150 4 , , PUNCT bam-8931 150 5 aerobic aerobic ADJ bam-8931 150 6 exercise exercise NOUN bam-8931 150 7 could could AUX bam-8931 150 8 potentially potentially ADV bam-8931 150 9 be be AUX bam-8931 150 10 a a DET bam-8931 150 11 promising promising ADJ bam-8931 150 12 intervention intervention NOUN bam-8931 150 13 strategy strategy NOUN bam-8931 150 14 for for ADP bam-8931 150 15 the the DET bam-8931 150 16 prevention prevention NOUN bam-8931 150 17 and and CCONJ bam-8931 150 18 treatment treatment NOUN bam-8931 150 19 of of ADP bam-8931 150 20 cc cc PROPN bam-8931 150 21 . . PUNCT bam-8931 151 1 different different ADJ bam-8931 151 2 studies study NOUN bam-8931 151 3 confirm confirm VERB bam-8931 151 4 the the DET bam-8931 151 5 beneficial beneficial ADJ bam-8931 151 6 effect effect NOUN bam-8931 151 7 of of ADP bam-8931 151 8 aerobic aerobic ADJ bam-8931 151 9 training training NOUN bam-8931 151 10 in in ADP bam-8931 151 11 diseases disease NOUN bam-8931 151 12 presenting present VERB bam-8931 151 13 impaired impaired ADJ bam-8931 151 14 oxidative oxidative ADJ bam-8931 151 15 metabolism metabolism NOUN bam-8931 151 16 . . PUNCT bam-8931 152 1 murphy murphy PROPN bam-8931 152 2 et et PROPN bam-8931 152 3 al.43 al.43 PROPN bam-8931 152 4 showed show VERB bam-8931 152 5 an an DET bam-8931 152 6 increase increase NOUN bam-8931 152 7 in in ADP bam-8931 152 8 muscle muscle NOUN bam-8931 152 9 performance performance NOUN bam-8931 152 10 with with ADP bam-8931 152 11 reduced reduced ADJ bam-8931 152 12 fatigue fatigue NOUN bam-8931 152 13 and and CCONJ bam-8931 152 14 lactate lactate NOUN bam-8931 152 15 production production NOUN bam-8931 152 16 in in ADP bam-8931 152 17 a a DET bam-8931 152 18 group group NOUN bam-8931 152 19 of of ADP bam-8931 152 20 patients patient NOUN bam-8931 152 21 with with ADP bam-8931 152 22 mitochondrial mitochondrial ADJ bam-8931 152 23 myopathies myopathy NOUN bam-8931 152 24 due due ADJ bam-8931 152 25 to to ADP bam-8931 152 26 deletions deletion NOUN bam-8931 152 27 of of ADP bam-8931 152 28 mitochondrial mitochondrial ADJ bam-8931 152 29 dna dna NOUN bam-8931 152 30 after after ADP bam-8931 152 31 an an DET bam-8931 152 32 aerobic aerobic ADJ bam-8931 152 33 training training NOUN bam-8931 152 34 . . PUNCT bam-8931 153 1 recently recently ADV bam-8931 153 2 , , PUNCT bam-8931 153 3 our our PRON bam-8931 153 4 group group NOUN bam-8931 153 5 demonstrated demonstrate VERB bam-8931 153 6 the the DET bam-8931 153 7 effectiveness effectiveness NOUN bam-8931 153 8 of of ADP bam-8931 153 9 an an DET bam-8931 153 10 aerobic aerobic ADJ bam-8931 153 11 training training NOUN bam-8931 153 12 in in ADP bam-8931 153 13 a a DET bam-8931 153 14 patient patient NOUN bam-8931 153 15 with with ADP bam-8931 153 16 polymyositis polymyositis PROPN bam-8931 153 17 in in ADP bam-8931 153 18 chronic chronic ADJ bam-8931 153 19 phase phase NOUN bam-8931 153 20 with with ADP bam-8931 153 21 impairment impairment NOUN bam-8931 153 22 of of ADP bam-8931 153 23 muscle muscle NOUN bam-8931 153 24 oxidative oxidative ADJ bam-8931 153 25 metabolism.44 metabolism.44 NOUN bam-8931 153 26 mitochondria mitochondria NOUN bam-8931 153 27 are be AUX bam-8931 153 28 dynamic dynamic ADJ bam-8931 153 29 organelles organelle NOUN bam-8931 153 30 in in ADP bam-8931 153 31 skeletal skeletal ADJ bam-8931 153 32 muscle muscle NOUN bam-8931 153 33 , , PUNCT bam-8931 153 34 critical critical ADJ bam-8931 153 35 in in ADP bam-8931 153 36 physical physical ADJ bam-8931 153 37 performance performance NOUN bam-8931 153 38 and and CCONJ bam-8931 153 39 disease disease NOUN bam-8931 153 40 . . PUNCT bam-8931 154 1 the the DET bam-8931 154 2 mitochondrial mitochondrial ADJ bam-8931 154 3 life life NOUN bam-8931 154 4 cycle cycle NOUN bam-8931 154 5 spans span NOUN bam-8931 154 6 biogenesis biogenesis NOUN bam-8931 154 7 , , PUNCT bam-8931 154 8 maintenance maintenance NOUN bam-8931 154 9 , , PUNCT bam-8931 154 10 and and CCONJ bam-8931 154 11 clearance clearance NOUN bam-8931 154 12 . . PUNCT bam-8931 155 1 exercise exercise NOUN bam-8931 155 2 training training NOUN bam-8931 155 3 may may AUX bam-8931 155 4 promote promote VERB bam-8931 155 5 each each PRON bam-8931 155 6 of of ADP bam-8931 155 7 these these DET bam-8931 155 8 processes process NOUN bam-8931 155 9 , , PUNCT bam-8931 155 10 conferring confer VERB bam-8931 155 11 positive positive ADJ bam-8931 155 12 impacts impact NOUN bam-8931 155 13 on on ADP bam-8931 155 14 skeletal skeletal ADJ bam-8931 155 15 muscle muscle NOUN bam-8931 155 16 contractile contractile NOUN bam-8931 155 17 and and CCONJ bam-8931 155 18 metabolic metabolic NOUN bam-8931 155 19 functions.45 functions.45 PROPN bam-8931 155 20 finally finally ADV bam-8931 155 21 , , PUNCT bam-8931 155 22 also also ADV bam-8931 155 23 the the DET bam-8931 155 24 role role NOUN bam-8931 155 25 of of ADP bam-8931 155 26 resistance resistance NOUN bam-8931 155 27 exercise exercise NOUN bam-8931 155 28 must must AUX bam-8931 155 29 be be AUX bam-8931 155 30 considered consider VERB bam-8931 155 31 : : PUNCT bam-8931 155 32 resistance resistance NOUN bam-8931 155 33 exercise exercise NOUN bam-8931 155 34 has have AUX bam-8931 155 35 been be AUX bam-8931 155 36 demonstrated demonstrate VERB bam-8931 155 37 to to PART bam-8931 155 38 be be AUX bam-8931 155 39 a a DET bam-8931 155 40 potent potent ADJ bam-8931 155 41 stimulant stimulant NOUN bam-8931 155 42 for for ADP bam-8931 155 43 increasing increase VERB bam-8931 155 44 protein protein NOUN bam-8931 155 45 synthesis synthesis NOUN bam-8931 155 46 and and CCONJ bam-8931 155 47 has have AUX bam-8931 155 48 been be AUX bam-8931 155 49 shown show VERB bam-8931 155 50 to to PART bam-8931 155 51 reverse reverse VERB bam-8931 155 52 skeletal skeletal ADJ bam-8931 155 53 muscle muscle NOUN bam-8931 155 54 wasting waste VERB bam-8931 155 55 in in ADP bam-8931 155 56 other other ADJ bam-8931 155 57 diseases disease NOUN bam-8931 155 58 , , PUNCT bam-8931 155 59 increasing increase VERB bam-8931 155 60 muscle muscle NOUN bam-8931 155 61 strength strength NOUN bam-8931 155 62 and and CCONJ bam-8931 155 63 lean lean ADJ bam-8931 155 64 body body NOUN bam-8931 155 65 mass.46 mass.46 NOUN bam-8931 155 66 adaptations adaptation NOUN bam-8931 155 67 to to PART bam-8931 155 68 endurance endurance NOUN bam-8931 155 69 exercise exercise NOUN bam-8931 155 70 include include VERB bam-8931 155 71 improved improve VERB bam-8931 155 72 oxygen oxygen NOUN bam-8931 155 73 delivery delivery NOUN bam-8931 155 74 to to ADP bam-8931 155 75 muscles muscle NOUN bam-8931 155 76 and and CCONJ bam-8931 155 77 increased increase VERB bam-8931 155 78 oxidative oxidative ADJ bam-8931 155 79 capacity.47 capacity.47 NOUN bam-8931 155 80 although although SCONJ bam-8931 155 81 there there PRON bam-8931 155 82 is be VERB bam-8931 155 83 little little ADJ bam-8931 155 84 evidence evidence NOUN bam-8931 155 85 for for ADP bam-8931 155 86 the the DET bam-8931 155 87 support support NOUN bam-8931 155 88 of of ADP bam-8931 155 89 resistance resistance NOUN bam-8931 155 90 training training NOUN bam-8931 155 91 in in ADP bam-8931 155 92 cc cc PROPN bam-8931 155 93 , , PUNCT bam-8931 155 94 the the DET bam-8931 155 95 positive positive ADJ bam-8931 155 96 effects effect NOUN bam-8931 155 97 on on ADP bam-8931 155 98 lean lean ADJ bam-8931 155 99 muscle muscle NOUN bam-8931 155 100 mass mass NOUN bam-8931 155 101 , , PUNCT bam-8931 155 102 strength strength NOUN bam-8931 155 103 and and CCONJ bam-8931 155 104 muscle muscle NOUN bam-8931 155 105 function function NOUN bam-8931 155 106 in in ADP bam-8931 155 107 other other ADJ bam-8931 155 108 populations population NOUN bam-8931 155 109 experiencing experience VERB bam-8931 155 110 muscle muscle NOUN bam-8931 155 111 wasting waste VERB bam-8931 155 112 indicates indicate VERB bam-8931 155 113 that that PRON bam-8931 155 114 is be AUX bam-8931 155 115 an an DET bam-8931 155 116 effective effective ADJ bam-8931 155 117 intervention intervention NOUN bam-8931 155 118 for for ADP bam-8931 155 119 the the DET bam-8931 155 120 attenuation attenuation NOUN bam-8931 155 121 of of ADP bam-8931 155 122 progressive progressive ADJ bam-8931 155 123 muscle muscle NOUN bam-8931 155 124 wasting waste VERB bam-8931 155 125 . . PUNCT bam-8931 156 1 in in ADP bam-8931 156 2 cancer cancer NOUN bam-8931 156 3 patients patient NOUN bam-8931 156 4 , , PUNCT bam-8931 156 5 there there PRON bam-8931 156 6 is be VERB bam-8931 156 7 evidence evidence NOUN bam-8931 156 8 that that SCONJ bam-8931 156 9 physical physical ADJ bam-8931 156 10 exercise exercise NOUN bam-8931 156 11 contributes contribute VERB bam-8931 156 12 to to PART bam-8931 156 13 reduce reduce VERB bam-8931 156 14 fatigue fatigue NOUN bam-8931 156 15 , , PUNCT bam-8931 156 16 to to PART bam-8931 156 17 improve improve VERB bam-8931 156 18 qol qol NOUN bam-8931 156 19 and and CCONJ bam-8931 156 20 to to PART bam-8931 156 21 relieve relieve VERB bam-8931 156 22 many many ADJ bam-8931 156 23 of of ADP bam-8931 156 24 the the DET bam-8931 156 25 side side NOUN bam-8931 156 26 effects effect NOUN bam-8931 156 27 experienced experience VERB bam-8931 156 28 both both CCONJ bam-8931 156 29 during during ADP bam-8931 156 30 and and CCONJ bam-8931 156 31 after after ADP bam-8931 156 32 “ " PUNCT bam-8931 156 33 neoplastic neoplastic ADJ bam-8931 156 34 ” " PUNCT bam-8931 156 35 managements management NOUN bam-8931 156 36 . . PUNCT bam-8931 157 1 hopefully hopefully ADV bam-8931 157 2 , , PUNCT bam-8931 157 3 by by ADP bam-8931 157 4 implementing implement VERB bam-8931 157 5 appropriate appropriate ADJ bam-8931 157 6 exercise exercise NOUN bam-8931 157 7 interventions intervention NOUN bam-8931 157 8 it it PRON bam-8931 157 9 might might AUX bam-8931 157 10 be be AUX bam-8931 157 11 possible possible ADJ bam-8931 157 12 to to PART bam-8931 157 13 prevent prevent VERB bam-8931 157 14 the the DET bam-8931 157 15 wasting wasting NOUN bam-8931 157 16 typical typical ADJ bam-8931 157 17 of of ADP bam-8931 157 18 cachexia cachexia NOUN bam-8931 157 19 . . PUNCT bam-8931 158 1 however however ADV bam-8931 158 2 , , PUNCT bam-8931 158 3 our our PRON bam-8931 158 4 study study NOUN bam-8931 158 5 does do AUX bam-8931 158 6 have have VERB bam-8931 158 7 some some DET bam-8931 158 8 limitations limitation NOUN bam-8931 158 9 . . PUNCT bam-8931 159 1 the the DET bam-8931 159 2 first first ADJ bam-8931 159 3 one one NOUN bam-8931 159 4 is be AUX bam-8931 159 5 the the DET bam-8931 159 6 small small ADJ bam-8931 159 7 number number NOUN bam-8931 159 8 of of ADP bam-8931 159 9 patients patient NOUN bam-8931 159 10 included include VERB bam-8931 159 11 in in ADP bam-8931 159 12 the the DET bam-8931 159 13 analysis analysis NOUN bam-8931 159 14 and and CCONJ bam-8931 159 15 the the DET bam-8931 159 16 unbalanced unbalanced ADJ bam-8931 159 17 ratio ratio NOUN bam-8931 159 18 male male NOUN bam-8931 159 19 / / SYM bam-8931 159 20 female female NOUN bam-8931 159 21 , , PUNCT bam-8931 159 22 which which PRON bam-8931 159 23 makes make VERB bam-8931 159 24 further further ADJ bam-8931 159 25 studies study NOUN bam-8931 159 26 in in ADP bam-8931 159 27 a a DET bam-8931 159 28 major major ADJ bam-8931 159 29 number number NOUN bam-8931 159 30 of of ADP bam-8931 159 31 patients patient NOUN bam-8931 159 32 mandatory mandatory ADJ bam-8931 159 33 . . PUNCT bam-8931 160 1 the the DET bam-8931 160 2 second second ADJ bam-8931 160 3 limitation limitation NOUN bam-8931 160 4 is be AUX bam-8931 160 5 the the DET bam-8931 160 6 inclusion inclusion NOUN bam-8931 160 7 of of ADP bam-8931 160 8 both both CCONJ bam-8931 160 9 metastatic metastatic ADJ bam-8931 160 10 and and CCONJ bam-8931 160 11 non non ADJ bam-8931 160 12 - - ADJ bam-8931 160 13 metastatic metastatic ADJ bam-8931 160 14 cancer cancer NOUN bam-8931 160 15 patients patient NOUN bam-8931 160 16 . . PUNCT bam-8931 161 1 it it PRON bam-8931 161 2 is be AUX bam-8931 161 3 known know VERB bam-8931 161 4 that that SCONJ bam-8931 161 5 metastatic metastatic ADJ bam-8931 161 6 patients patient NOUN bam-8931 161 7 do do AUX bam-8931 161 8 have have VERB bam-8931 161 9 major major ADJ bam-8931 161 10 problems problem NOUN bam-8931 161 11 in in ADP bam-8931 161 12 terms term NOUN bam-8931 161 13 of of ADP bam-8931 161 14 lean lean ADJ bam-8931 161 15 muscle muscle NOUN bam-8931 161 16 mass mass NOUN bam-8931 161 17 loss loss NOUN bam-8931 161 18 and and CCONJ bam-8931 161 19 , , PUNCT bam-8931 161 20 in in ADP bam-8931 161 21 general general ADJ bam-8931 161 22 , , PUNCT bam-8931 161 23 are be AUX bam-8931 161 24 more more ADV bam-8931 161 25 prone prone ADJ bam-8931 161 26 to to ADP bam-8931 161 27 developing develop VERB bam-8931 161 28 cachexia cachexia NOUN bam-8931 161 29 . . PUNCT bam-8931 162 1 on on ADP bam-8931 162 2 the the DET bam-8931 162 3 other other ADJ bam-8931 162 4 hand hand NOUN bam-8931 162 5 , , PUNCT bam-8931 162 6 even even ADV bam-8931 162 7 if if SCONJ bam-8931 162 8 the the DET bam-8931 162 9 number number NOUN bam-8931 162 10 of of ADP bam-8931 162 11 patients patient NOUN bam-8931 162 12 was be AUX bam-8931 162 13 limited limit VERB bam-8931 162 14 and and CCONJ bam-8931 162 15 made make VERB bam-8931 162 16 up up ADP bam-8931 162 17 of of ADP bam-8931 162 18 both both CCONJ bam-8931 162 19 metastatic metastatic ADJ bam-8931 162 20 and and CCONJ bam-8931 162 21 non non ADJ bam-8931 162 22 - - ADJ bam-8931 162 23 metastatic metastatic ADJ bam-8931 162 24 patients patient NOUN bam-8931 162 25 , , PUNCT bam-8931 162 26 our our PRON bam-8931 162 27 patients patient NOUN bam-8931 162 28 did do AUX bam-8931 162 29 have have VERB bam-8931 162 30 similar similar ADJ bam-8931 162 31 clinical clinical ADJ bam-8931 162 32 features feature NOUN bam-8931 162 33 and and CCONJ bam-8931 162 34 none none NOUN bam-8931 162 35 of of ADP bam-8931 162 36 them they PRON bam-8931 162 37 referred refer VERB bam-8931 162 38 any any DET bam-8931 162 39 meaningful meaningful ADJ bam-8931 162 40 weight weight NOUN bam-8931 162 41 loss loss NOUN bam-8931 162 42 or or CCONJ bam-8931 162 43 other other ADJ bam-8931 162 44 cachexia cachexia NOUN bam-8931 162 45 - - PUNCT bam-8931 162 46 related relate VERB bam-8931 162 47 symptoms symptom NOUN bam-8931 162 48 . . PUNCT bam-8931 163 1 all all DET bam-8931 163 2 this this PRON bam-8931 163 3 considered consider VERB bam-8931 163 4 , , PUNCT bam-8931 163 5 this this PRON bam-8931 163 6 might might AUX bam-8931 163 7 also also ADV bam-8931 163 8 be be AUX bam-8931 163 9 proof proof NOUN bam-8931 163 10 that that SCONJ bam-8931 163 11 muscle muscle NOUN bam-8931 163 12 metabolism metabolism NOUN bam-8931 163 13 - - PUNCT bam-8931 163 14 related relate VERB bam-8931 163 15 problems problem NOUN bam-8931 163 16 are be AUX bam-8931 163 17 a a DET bam-8931 163 18 more more ADV bam-8931 163 19 widespread widespread ADJ bam-8931 163 20 problem problem NOUN bam-8931 163 21 in in ADP bam-8931 163 22 cancer cancer NOUN bam-8931 163 23 patients patient NOUN bam-8931 163 24 than than ADP bam-8931 163 25 what what PRON bam-8931 163 26 known know VERB bam-8931 163 27 from from ADP bam-8931 163 28 the the DET bam-8931 163 29 literature literature NOUN bam-8931 163 30 and and CCONJ bam-8931 163 31 might might AUX bam-8931 163 32 be be AUX bam-8931 163 33 a a DET bam-8931 163 34 precocious precocious ADJ bam-8931 163 35 sign sign NOUN bam-8931 163 36 of of ADP bam-8931 163 37 further far ADV bam-8931 163 38 , , PUNCT bam-8931 163 39 more more ADV bam-8931 163 40 clinically clinically ADV bam-8931 163 41 relevant relevant ADJ bam-8931 163 42 problems problem NOUN bam-8931 163 43 . . PUNCT bam-8931 164 1 further further ADJ bam-8931 164 2 studies study NOUN bam-8931 164 3 should should AUX bam-8931 164 4 then then ADV bam-8931 164 5 be be AUX bam-8931 164 6 performed perform VERB bam-8931 164 7 to to PART bam-8931 164 8 confirm confirm VERB bam-8931 164 9 these these DET bam-8931 164 10 hypotheses hypothesis NOUN bam-8931 164 11 . . PUNCT bam-8931 165 1 in in ADP bam-8931 165 2 conclusion conclusion NOUN bam-8931 165 3 , , PUNCT bam-8931 165 4 data datum NOUN bam-8931 165 5 emerging emerge VERB bam-8931 165 6 from from ADP bam-8931 165 7 this this DET bam-8931 165 8 study study NOUN bam-8931 165 9 highlight highlight VERB bam-8931 165 10 an an DET bam-8931 165 11 impairment impairment NOUN bam-8931 165 12 of of ADP bam-8931 165 13 muscle muscle NOUN bam-8931 165 14 oxidative oxidative ADJ bam-8931 165 15 metabolism metabolism NOUN bam-8931 165 16 in in ADP bam-8931 165 17 cancer cancer NOUN bam-8931 165 18 patients patient NOUN bam-8931 165 19 with with ADP bam-8931 165 20 no no DET bam-8931 165 21 signs sign NOUN bam-8931 165 22 of of ADP bam-8931 165 23 pre pre NOUN bam-8931 165 24 - - ADJ bam-8931 165 25 cachexia cachexia ADJ bam-8931 165 26 or or CCONJ bam-8931 165 27 cachexia cachexia NOUN bam-8931 165 28 . . PUNCT bam-8931 166 1 a a DET bam-8931 166 2 trend trend NOUN bam-8931 166 3 of of ADP bam-8931 166 4 precocious precocious ADJ bam-8931 166 5 fatigability fatigability NOUN bam-8931 166 6 and and CCONJ bam-8931 166 7 an an DET bam-8931 166 8 impairment impairment NOUN bam-8931 166 9 of of ADP bam-8931 166 10 muscle muscle NOUN bam-8931 166 11 strength strength NOUN bam-8931 166 12 production production NOUN bam-8931 166 13 were be AUX bam-8931 166 14 also also ADV bam-8931 166 15 observed observe VERB bam-8931 166 16 . . PUNCT bam-8931 167 1 these these DET bam-8931 167 2 data datum NOUN bam-8931 167 3 , , PUNCT bam-8931 167 4 if if SCONJ bam-8931 167 5 further far ADV bam-8931 167 6 independently independently ADV bam-8931 167 7 confirmed confirm VERB bam-8931 167 8 , , PUNCT bam-8931 167 9 underline underline VERB bam-8931 167 10 the the DET bam-8931 167 11 relevance relevance NOUN bam-8931 167 12 of of ADP bam-8931 167 13 an an DET bam-8931 167 14 early early ADJ bam-8931 167 15 assessment assessment NOUN bam-8931 167 16 of of ADP bam-8931 167 17 muscle muscle NOUN bam-8931 167 18 function function NOUN bam-8931 167 19 in in ADP bam-8931 167 20 oncologic oncologic ADJ bam-8931 167 21 patients patient NOUN bam-8931 167 22 in in ADP bam-8931 167 23 order order NOUN bam-8931 167 24 to to PART bam-8931 167 25 early early ADV bam-8931 167 26 propose propose VERB bam-8931 167 27 rehabilitative rehabilitative ADJ bam-8931 167 28 approaches approach NOUN bam-8931 167 29 that that PRON bam-8931 167 30 could could AUX bam-8931 167 31 counteract counteract VERB bam-8931 167 32 motor motor NOUN bam-8931 167 33 impairment impairment NOUN bam-8931 167 34 and and CCONJ bam-8931 167 35 eventually eventually ADV bam-8931 167 36 to to PART bam-8931 167 37 slow slow VERB bam-8931 167 38 down down ADP bam-8931 167 39 and/or and/or CCONJ bam-8931 167 40 prevent prevent VERB bam-8931 167 41 cancer cancer NOUN bam-8931 167 42 cachexia cachexia NOUN bam-8931 167 43 . . PUNCT bam-8931 168 1 muscle muscle NOUN bam-8931 168 2 impairment impairment NOUN bam-8931 168 3 in in ADP bam-8931 168 4 pre pre ADJ bam-8931 168 5 - - ADJ bam-8931 168 6 cachexia cachexia ADJ bam-8931 168 7 cancer cancer NOUN bam-8931 168 8 patients patient NOUN bam-8931 168 9 eur eur PROPN bam-8931 168 10 j j PROPN bam-8931 168 11 transl transl PROPN bam-8931 168 12 myol myol ADV bam-8931 168 13 30 30 NUM bam-8931 168 14 ( ( PUNCT bam-8931 168 15 2 2 NUM bam-8931 168 16 ): ): PUNCT bam-8931 168 17 258 258 NUM bam-8931 168 18 - - SYM bam-8931 168 19 267 267 NUM bam-8931 168 20 , , PUNCT bam-8931 168 21 2020 2020 NUM bam-8931 168 22 265 265 NUM bam-8931 168 23 list list NOUN bam-8931 168 24 of of ADP bam-8931 168 25 acronyms acronym NOUN bam-8931 168 26 acei acei PROPN bam-8931 168 27 angiotensin angiotensin NOUN bam-8931 168 28 - - PUNCT bam-8931 168 29 converting convert VERB bam-8931 168 30 enzyme enzyme NOUN bam-8931 168 31 inhibitors inhibitor NOUN bam-8931 168 32 aghr aghr ADJ bam-8931 168 33 acyl acyl NOUN bam-8931 168 34 ghrelin ghrelin NOUN bam-8931 168 35 aht aht VERB bam-8931 168 36 arterial arterial ADJ bam-8931 168 37 hypertension hypertension NOUN bam-8931 168 38 anova anova VERB bam-8931 168 39 analysis analysis NOUN bam-8931 168 40 of of ADP bam-8931 168 41 variance variance NOUN bam-8931 168 42 atp atp NOUN bam-8931 168 43 adenosine adenosine NOUN bam-8931 168 44 triphosphate triphosphate NOUN bam-8931 168 45 avp avp NOUN bam-8931 168 46 arginine arginine NOUN bam-8931 168 47 vasopressin vasopressin NOUN bam-8931 168 48 baa baa NOUN bam-8931 168 49 beta beta ADJ bam-8931 168 50 adrenergic adrenergic ADJ bam-8931 168 51 agonist agonist NOUN bam-8931 168 52 bmi bmi NOUN bam-8931 168 53 body body PROPN bam-8931 168 54 mass mass PROPN bam-8931 168 55 index index PROPN bam-8931 168 56 cc cc PROPN bam-8931 168 57 cancer cancer NOUN bam-8931 168 58 cachexia cachexia PROPN bam-8931 168 59 copd copd PROPN bam-8931 168 60 chronic chronic ADJ bam-8931 168 61 obstructive obstructive ADJ bam-8931 168 62 pulmonary pulmonary ADJ bam-8931 168 63 disease disease NOUN bam-8931 168 64 ct ct NUM bam-8931 168 65 chemotherapy chemotherapy NOUN bam-8931 168 66 dghr dghr NOUN bam-8931 168 67 des des ADJ bam-8931 168 68 - - ADJ bam-8931 168 69 acyl acyl ADJ bam-8931 168 70 ghrelin ghrelin NOUN bam-8931 168 71 edta edta NOUN bam-8931 168 72 ethylene ethylene NOUN bam-8931 168 73 diamine diamine NOUN bam-8931 168 74 tetraacetic tetraacetic NOUN bam-8931 168 75 acid acid NOUN bam-8931 168 76 f f PROPN bam-8931 168 77 female female ADJ bam-8931 168 78 h h NOUN bam-8931 168 79 hypercholesterolemia hypercholesterolemia NOUN bam-8931 168 80 ifnγ ifnγ NOUN bam-8931 168 81 interferon interferon PROPN bam-8931 168 82 gamma gamma PROPN bam-8931 168 83 il-6 il-6 PROPN bam-8931 168 84 interleukin interleukin NOUN bam-8931 168 85 6 6 NUM bam-8931 168 86 m m NOUN bam-8931 168 87 male male NOUN bam-8931 168 88 mafbx mafbx NOUN bam-8931 168 89 atrogin-1 atrogin-1 PROPN bam-8931 168 90 / / SYM bam-8931 168 91 muscle muscle NOUN bam-8931 168 92 atrophy atrophy NOUN bam-8931 168 93 f f PROPN bam-8931 168 94 - - PUNCT bam-8931 168 95 box box NOUN bam-8931 168 96 murf1 murf1 NOUN bam-8931 168 97 muscle muscle NOUN bam-8931 169 1 ring ring NOUN bam-8931 169 2 finger finger NOUN bam-8931 169 3 protein protein NOUN bam-8931 169 4 1 1 NUM bam-8931 169 5 mvc mvc NOUN bam-8931 169 6 maximum maximum ADJ bam-8931 169 7 voluntary voluntary ADJ bam-8931 169 8 contraction contraction NOUN bam-8931 169 9 pif pif NOUN bam-8931 169 10 proteolysis proteolysis NOUN bam-8931 169 11 - - PUNCT bam-8931 169 12 inducing induce VERB bam-8931 169 13 factors factor NOUN bam-8931 169 14 qol qol VERB bam-8931 169 15 quality quality NOUN bam-8931 169 16 of of ADP bam-8931 169 17 life life NOUN bam-8931 169 18 rt rt PROPN bam-8931 169 19 radiotherapy radiotherapy PROPN bam-8931 169 20 st st PROPN bam-8931 169 21 surgical surgical ADJ bam-8931 169 22 therapy therapy NOUN bam-8931 169 23 tnfα tnfα NOUN bam-8931 169 24 tumor tumor NOUN bam-8931 169 25 necrosis necrosis NOUN bam-8931 169 26 factor factor NOUN bam-8931 169 27 alpha alpha NOUN bam-8931 169 28 authors author NOUN bam-8931 169 29 contributions contribution VERB bam-8931 169 30 sd sd ADP bam-8931 169 31 and and CCONJ bam-8931 169 32 cc cc ADP bam-8931 169 33 designed design VERB bam-8931 169 34 the the DET bam-8931 169 35 study study NOUN bam-8931 169 36 . . PUNCT bam-8931 170 1 lg lg NOUN bam-8931 170 2 and and CCONJ bam-8931 170 3 as as ADP bam-8931 170 4 enrolled enrol VERB bam-8931 170 5 patients patient NOUN bam-8931 170 6 . . PUNCT bam-8931 171 1 sd sd NOUN bam-8931 171 2 conducted conduct VERB bam-8931 171 3 the the DET bam-8931 171 4 muscular muscular ADJ bam-8931 171 5 function function NOUN bam-8931 171 6 assessment assessment NOUN bam-8931 171 7 and and CCONJ bam-8931 171 8 collected collect VERB bam-8931 171 9 clinical clinical ADJ bam-8931 171 10 data datum NOUN bam-8931 171 11 . . PUNCT bam-8931 172 1 pt pt PROPN bam-8931 172 2 performed perform VERB bam-8931 172 3 data datum NOUN bam-8931 172 4 analysis analysis NOUN bam-8931 172 5 . . PUNCT bam-8931 173 1 sd sd NOUN bam-8931 173 2 and and CCONJ bam-8931 173 3 cc cc PROPN bam-8931 173 4 contributed contribute VERB bam-8931 173 5 to to ADP bam-8931 173 6 data data NOUN bam-8931 173 7 analysis analysis NOUN bam-8931 173 8 and and CCONJ bam-8931 173 9 interpretation interpretation NOUN bam-8931 173 10 . . PUNCT bam-8931 174 1 sd sd NOUN bam-8931 174 2 drafted draft VERB bam-8931 174 3 the the DET bam-8931 174 4 manuscript manuscript NOUN bam-8931 174 5 . . PUNCT bam-8931 175 1 all all DET bam-8931 175 2 authors author NOUN bam-8931 175 3 read read VERB bam-8931 175 4 and and CCONJ bam-8931 175 5 approved approve VERB bam-8931 175 6 the the DET bam-8931 175 7 final final ADJ bam-8931 175 8 version version NOUN bam-8931 175 9 of of ADP bam-8931 175 10 the the DET bam-8931 175 11 manuscript manuscript NOUN bam-8931 175 12 . . PUNCT bam-8931 176 1 acknowledgments acknowledgment NOUN bam-8931 176 2 the the DET bam-8931 176 3 authors author NOUN bam-8931 176 4 wish wish VERB bam-8931 176 5 to to PART bam-8931 176 6 thank thank VERB bam-8931 176 7 all all DET bam-8931 176 8 the the DET bam-8931 176 9 participants participant NOUN bam-8931 176 10 enrolled enrol VERB bam-8931 176 11 in in ADP bam-8931 176 12 the the DET bam-8931 176 13 study study NOUN bam-8931 176 14 for for ADP bam-8931 176 15 their their PRON bam-8931 176 16 time time NOUN bam-8931 176 17 and and CCONJ bam-8931 176 18 contributions contribution NOUN bam-8931 176 19 . . PUNCT bam-8931 177 1 funding fund VERB bam-8931 177 2 this this DET bam-8931 177 3 work work NOUN bam-8931 177 4 was be AUX bam-8931 177 5 supported support VERB bam-8931 177 6 from from ADP bam-8931 177 7 italian italian ADJ bam-8931 177 8 ministry ministry PROPN bam-8931 177 9 of of ADP bam-8931 177 10 education education PROPN bam-8931 177 11 , , PUNCT bam-8931 177 12 universities university NOUN bam-8931 177 13 and and CCONJ bam-8931 177 14 research research NOUN bam-8931 177 15 ( ( PUNCT bam-8931 177 16 miur miur NOUN bam-8931 177 17 ) ) PUNCT bam-8931 177 18 ( ( PUNCT bam-8931 177 19 prin prin NOUN bam-8931 177 20 2009/2011 2009/2011 NUM bam-8931 177 21 to to ADP bam-8931 177 22 cc cc PROPN bam-8931 177 23 as as ADP bam-8931 177 24 coinvestigator coinvestigator NOUN bam-8931 177 25 ) ) PUNCT bam-8931 177 26 . . PUNCT bam-8931 178 1 conflict conflict NOUN bam-8931 178 2 of of ADP bam-8931 178 3 interest interest NOUN bam-8931 178 4 the the DET bam-8931 178 5 authors author NOUN bam-8931 178 6 declare declare VERB bam-8931 178 7 they they PRON bam-8931 178 8 have have VERB bam-8931 178 9 no no DET bam-8931 178 10 conflicts conflict NOUN bam-8931 178 11 of of ADP bam-8931 178 12 interest interest NOUN bam-8931 178 13 . . PUNCT bam-8931 179 1 ethical ethical ADJ bam-8931 179 2 publication publication NOUN bam-8931 179 3 statement statement NOUN bam-8931 179 4 we we PRON bam-8931 179 5 confirm confirm VERB bam-8931 179 6 that that SCONJ bam-8931 179 7 we we PRON bam-8931 179 8 have have AUX bam-8931 179 9 read read VERB bam-8931 179 10 the the DET bam-8931 179 11 journal journal NOUN bam-8931 179 12 ’s ’s PART bam-8931 179 13 position position NOUN bam-8931 179 14 on on ADP bam-8931 179 15 issues issue NOUN bam-8931 179 16 involved involve VERB bam-8931 179 17 in in ADP bam-8931 179 18 ethical ethical ADJ bam-8931 179 19 publication publication NOUN bam-8931 179 20 and and CCONJ bam-8931 179 21 affirm affirm NOUN bam-8931 179 22 that that SCONJ bam-8931 179 23 this this DET bam-8931 179 24 report report NOUN bam-8931 179 25 is be AUX bam-8931 179 26 consistent consistent ADJ bam-8931 179 27 with with ADP bam-8931 179 28 those those DET bam-8931 179 29 guidelines guideline NOUN bam-8931 179 30 . . PUNCT bam-8931 180 1 corresponding correspond VERB bam-8931 180 2 author author PROPN bam-8931 180 3 dr dr PROPN bam-8931 180 4 . . PROPN bam-8931 180 5 stefania stefania PROPN bam-8931 180 6 dalise dalise PROPN bam-8931 180 7 , , PUNCT bam-8931 180 8 unit unit NOUN bam-8931 180 9 of of ADP bam-8931 180 10 neurorehabilitation neurorehabilitation NOUN bam-8931 180 11 , , PUNCT bam-8931 180 12 university university NOUN bam-8931 180 13 hospital hospital NOUN bam-8931 180 14 of of ADP bam-8931 180 15 pisa pisa PROPN bam-8931 180 16 , , PUNCT bam-8931 180 17 via via ADP bam-8931 180 18 paradisa paradisa NOUN bam-8931 180 19 2 2 NUM bam-8931 180 20 , , PUNCT bam-8931 180 21 56124 56124 NUM bam-8931 180 22 pisa pisa PROPN bam-8931 180 23 , , PUNCT bam-8931 180 24 italy italy PROPN bam-8931 180 25 . . PUNCT bam-8931 180 26 phone phone NOUN bam-8931 180 27 ; ; PUNCT bam-8931 180 28 +39 +39 PROPN bam-8931 180 29 050 050 NUM bam-8931 180 30 996907 996907 NUM bam-8931 180 31 ; ; PUNCT bam-8931 180 32 fax fax NOUN bam-8931 180 33 : : PUNCT bam-8931 180 34 +39 +39 PROPN bam-8931 180 35 050 050 NUM bam-8931 180 36 995723 995723 NUM bam-8931 180 37 . . PUNCT bam-8931 181 1 orcid orcid NOUN bam-8931 182 1 i i PRON bam-8931 182 2 d d NOUN bam-8931 182 3 : : PUNCT bam-8931 182 4 0000 0000 NUM bam-8931 182 5 - - PUNCT bam-8931 182 6 0002 0002 NUM bam-8931 182 7 - - PUNCT bam-8931 182 8 1422 1422 NUM bam-8931 182 9 - - SYM bam-8931 182 10 1539 1539 NUM bam-8931 182 11 e e NOUN bam-8931 182 12 - - NOUN bam-8931 182 13 mail mail NOUN bam-8931 182 14 : : PUNCT bam-8931 183 1 stefania.dalise@ao-pisa.toscana.it stefania.dalise@ao-pisa.toscana.it PROPN bam-8931 183 2 e e NOUN bam-8931 183 3 - - NOUN bam-8931 183 4 mails mail NOUN bam-8931 183 5 of of ADP bam-8931 183 6 co co NOUN bam-8931 183 7 - - NOUN bam-8931 183 8 authors author NOUN bam-8931 183 9 peppino peppino PROPN bam-8931 183 10 tropea tropea PROPN bam-8931 183 11 : : PUNCT bam-8931 183 12 p.tropea@ccppdezza.it p.tropea@ccppdezza.it X bam-8931 183 13 orcid orcid NOUN bam-8931 184 1 i i PRON bam-8931 184 2 d d NOUN bam-8931 184 3 : : PUNCT bam-8931 184 4 0000 0000 NUM bam-8931 184 5 - - PUNCT bam-8931 184 6 0001 0001 NUM bam-8931 184 7 - - PUNCT bam-8931 184 8 8238 8238 NUM bam-8931 184 9 - - SYM bam-8931 184 10 9619 9619 NUM bam-8931 184 11 luca luca PROPN bam-8931 184 12 galli galli NOUN bam-8931 184 13 : : PUNCT bam-8931 184 14 lugal71@yahoo.it lugal71@yahoo.it X bam-8931 184 15 orcid orcid NOUN bam-8931 185 1 i i PRON bam-8931 185 2 d d NOUN bam-8931 185 3 : : PUNCT bam-8931 185 4 0000 0000 NUM bam-8931 185 5 - - PUNCT bam-8931 185 6 0001 0001 NUM bam-8931 185 7 - - PUNCT bam-8931 185 8 6008 6008 NUM bam-8931 185 9 - - PUNCT bam-8931 185 10 0266 0266 NUM bam-8931 185 11 andrea andrea PROPN bam-8931 185 12 sbrana sbrana PROPN bam-8931 185 13 : : PUNCT bam-8931 186 1 andreasbrana89@gmail.com andreasbrana89@gmail.com X bam-8931 186 2 orcid orcid NOUN bam-8931 187 1 i i NOUN bam-8931 187 2 d d NOUN bam-8931 187 3 : : PUNCT bam-8931 187 4 0000 0000 NUM bam-8931 187 5 - - PUNCT bam-8931 187 6 0003 0003 NUM bam-8931 187 7 - - PUNCT bam-8931 187 8 4460 4460 NUM bam-8931 187 9 - - SYM bam-8931 187 10 5282 5282 NUM bam-8931 187 11 carmelo carmelo NOUN bam-8931 187 12 chisari chisari NOUN bam-8931 187 13 : : PUNCT bam-8931 187 14 c.chisari@ao-pisa.toscana.it c.chisari@ao-pisa.toscana.it NUM bam-8931 187 15 orcid orcid NOUN bam-8931 188 1 i i NOUN bam-8931 188 2 d d NOUN bam-8931 188 3 : : PUNCT bam-8931 188 4 0000 0000 NUM bam-8931 188 5 - - PUNCT bam-8931 188 6 0002 0002 NUM bam-8931 188 7 - - PUNCT bam-8931 188 8 1043 1043 NUM bam-8931 188 9 - - SYM bam-8931 188 10 7738 7738 NUM bam-8931 188 11 references reference NOUN bam-8931 188 12 1 1 NUM bam-8931 188 13 . . PUNCT bam-8931 189 1 tisdale tisdale PROPN bam-8931 189 2 mj mj PROPN bam-8931 189 3 . . PUNCT bam-8931 190 1 cachexia cachexia PROPN bam-8931 190 2 in in ADP bam-8931 190 3 cancer cancer NOUN bam-8931 190 4 patients patient NOUN bam-8931 190 5 . . PUNCT bam-8931 191 1 nat nat PROPN bam-8931 191 2 rev rev VERB bam-8931 191 3 cancer cancer NOUN bam-8931 191 4 2002;2:862 2002;2:862 NOUN bam-8931 191 5 - - SYM bam-8931 191 6 71 71 NUM bam-8931 191 7 . . NOUN bam-8931 192 1 2 2 NUM bam-8931 192 2 . . PUNCT bam-8931 192 3 dewys dewy VERB bam-8931 192 4 wd wd PROPN bam-8931 192 5 , , PUNCT bam-8931 192 6 begg begg PROPN bam-8931 192 7 c c PROPN bam-8931 192 8 , , PUNCT bam-8931 192 9 lavin lavin PROPN bam-8931 192 10 pt pt PROPN bam-8931 192 11 , , PUNCT bam-8931 192 12 et et PROPN bam-8931 192 13 al al PROPN bam-8931 192 14 . . PROPN bam-8931 193 1 prognostic prognostic ADJ bam-8931 193 2 effect effect NOUN bam-8931 193 3 of of ADP bam-8931 193 4 weight weight NOUN bam-8931 193 5 loss loss NOUN bam-8931 193 6 prior prior ADV bam-8931 193 7 to to ADP bam-8931 193 8 chemotherapy chemotherapy NOUN bam-8931 193 9 in in ADP bam-8931 193 10 cancer cancer NOUN bam-8931 193 11 patients patient NOUN bam-8931 193 12 . . PUNCT bam-8931 194 1 eastern eastern ADJ bam-8931 194 2 cooperative cooperative ADJ bam-8931 194 3 oncology oncology NOUN bam-8931 194 4 group group NOUN bam-8931 194 5 . . PUNCT bam-8931 195 1 am be AUX bam-8931 195 2 j j PROPN bam-8931 195 3 med me VERB bam-8931 195 4 1980;69:491 1980;69:491 PROPN bam-8931 195 5 - - SYM bam-8931 195 6 7 7 NUM bam-8931 195 7 . . NOUN bam-8931 195 8 3 3 NUM bam-8931 195 9 . . X bam-8931 196 1 evans evans PROPN bam-8931 196 2 wj wj PROPN bam-8931 196 3 , , PUNCT bam-8931 196 4 morley morley PROPN bam-8931 196 5 je je PROPN bam-8931 196 6 , , PUNCT bam-8931 196 7 argiles argiles PROPN bam-8931 196 8 j j PROPN bam-8931 196 9 , , PUNCT bam-8931 196 10 et et PROPN bam-8931 196 11 al al PROPN bam-8931 196 12 . . PUNCT bam-8931 197 1 cachexia cachexia PROPN bam-8931 197 2 : : PUNCT bam-8931 197 3 a a DET bam-8931 197 4 new new ADJ bam-8931 197 5 definition definition NOUN bam-8931 197 6 . . PUNCT bam-8931 198 1 clin clin PROPN bam-8931 198 2 nutr nutr PROPN bam-8931 198 3 2008;27:793 2008;27:793 NOUN bam-8931 198 4 - - SYM bam-8931 198 5 9 9 NUM bam-8931 198 6 . . NOUN bam-8931 198 7 4 4 NUM bam-8931 198 8 . . X bam-8931 198 9 inagaki inagaki PROPN bam-8931 198 10 j j PROPN bam-8931 198 11 , , PUNCT bam-8931 198 12 rodriguez rodriguez PROPN bam-8931 198 13 v v NOUN bam-8931 198 14 , , PUNCT bam-8931 198 15 bodey bodey NOUN bam-8931 198 16 gp gp NOUN bam-8931 198 17 . . PUNCT bam-8931 199 1 proceedings proceeding NOUN bam-8931 199 2 : : PUNCT bam-8931 199 3 causes cause NOUN bam-8931 199 4 of of ADP bam-8931 199 5 death death NOUN bam-8931 199 6 in in ADP bam-8931 199 7 cancer cancer NOUN bam-8931 199 8 patients patient NOUN bam-8931 199 9 . . PUNCT bam-8931 200 1 cancer cancer NOUN bam-8931 200 2 1974;33:568 1974;33:568 PROPN bam-8931 200 3 - - SYM bam-8931 200 4 73 73 NUM bam-8931 200 5 . . PUNCT bam-8931 201 1 5 5 NUM bam-8931 201 2 . . X bam-8931 201 3 le le PROPN bam-8931 201 4 bricon bricon PROPN bam-8931 201 5 t t PROPN bam-8931 201 6 , , PUNCT bam-8931 201 7 gugins gugin NOUN bam-8931 201 8 s s PROPN bam-8931 201 9 , , PUNCT bam-8931 201 10 cynober cynober ADJ bam-8931 201 11 l l NOUN bam-8931 201 12 , , PUNCT bam-8931 201 13 baracos baracos PROPN bam-8931 201 14 ve ve VERB bam-8931 201 15 . . PROPN bam-8931 201 16 negative negative ADJ bam-8931 201 17 impact impact NOUN bam-8931 201 18 of of ADP bam-8931 201 19 cancer cancer NOUN bam-8931 201 20 chemotherapy chemotherapy NOUN bam-8931 201 21 on on ADP bam-8931 201 22 protein protein NOUN bam-8931 201 23 metabolism metabolism NOUN bam-8931 201 24 in in ADP bam-8931 201 25 healthy healthy ADJ bam-8931 201 26 and and CCONJ bam-8931 201 27 tumor tumor NOUN bam-8931 201 28 - - PUNCT bam-8931 201 29 bearing bear VERB bam-8931 201 30 rats rat NOUN bam-8931 201 31 . . PUNCT bam-8931 202 1 metabolism metabolism NOUN bam-8931 202 2 1995;44:1340 1995;44:1340 NUM bam-8931 202 3 - - SYM bam-8931 202 4 8 8 NUM bam-8931 202 5 . . NOUN bam-8931 202 6 6 6 NUM bam-8931 202 7 . . X bam-8931 203 1 currow currow PROPN bam-8931 203 2 d d PROPN bam-8931 203 3 , , PUNCT bam-8931 203 4 temel temel PROPN bam-8931 203 5 js js PROPN bam-8931 203 6 , , PUNCT bam-8931 203 7 abernethy abernethy ADV bam-8931 203 8 a a PRON bam-8931 203 9 , , PUNCT bam-8931 203 10 et et PROPN bam-8931 203 11 al al PROPN bam-8931 203 12 . . PUNCT bam-8931 204 1 romana romana PROPN bam-8931 204 2 3 3 NUM bam-8931 204 3 : : PUNCT bam-8931 204 4 a a DET bam-8931 204 5 phase phase NOUN bam-8931 204 6 3 3 NUM bam-8931 204 7 safety safety NOUN bam-8931 204 8 extension extension NOUN bam-8931 204 9 study study NOUN bam-8931 204 10 of of ADP bam-8931 204 11 anamorelin anamorelin PROPN bam-8931 204 12 in in ADP bam-8931 204 13 advanced advanced ADJ bam-8931 204 14 non non ADJ bam-8931 204 15 - - ADJ bam-8931 204 16 small small ADJ bam-8931 204 17 - - PUNCT bam-8931 204 18 cell cell NOUN bam-8931 204 19 lung lung NOUN bam-8931 204 20 cancer cancer NOUN bam-8931 204 21 ( ( PUNCT bam-8931 204 22 nsclc nsclc NOUN bam-8931 204 23 ) ) PUNCT bam-8931 204 24 patients patient NOUN bam-8931 204 25 with with ADP bam-8931 204 26 cachexia cachexia PROPN bam-8931 204 27 . . PUNCT bam-8931 205 1 ann ann PROPN bam-8931 205 2 oncol oncol ADJ bam-8931 205 3 2017;28:1949 2017;28:1949 NUM bam-8931 205 4 - - SYM bam-8931 205 5 56 56 NUM bam-8931 205 6 . . NOUN bam-8931 206 1 7 7 X bam-8931 206 2 . . X bam-8931 206 3 temel temel PROPN bam-8931 206 4 js js PROPN bam-8931 206 5 , , PUNCT bam-8931 206 6 abernethy abernethy PROPN bam-8931 206 7 ap ap PROPN bam-8931 206 8 , , PUNCT bam-8931 206 9 currow currow PROPN bam-8931 206 10 dc dc PROPN bam-8931 206 11 , , PUNCT bam-8931 206 12 et et PROPN bam-8931 206 13 al al PROPN bam-8931 206 14 . . PROPN bam-8931 206 15 anamorelin anamorelin PROPN bam-8931 206 16 in in ADP bam-8931 206 17 patients patient NOUN bam-8931 206 18 with with ADP bam-8931 206 19 non non ADJ bam-8931 206 20 - - ADJ bam-8931 206 21 small small ADJ bam-8931 206 22 - - PUNCT bam-8931 206 23 cell cell NOUN bam-8931 206 24 lung lung NOUN bam-8931 206 25 cancer cancer NOUN bam-8931 206 26 and and CCONJ bam-8931 206 27 cachexia cachexia PROPN bam-8931 206 28 ( ( PUNCT bam-8931 206 29 romana romana PROPN bam-8931 206 30 1 1 NUM bam-8931 206 31 and and CCONJ bam-8931 206 32 romana romana PROPN bam-8931 206 33 2 2 NUM bam-8931 206 34 ): ): PUNCT bam-8931 206 35 results result NOUN bam-8931 206 36 from from ADP bam-8931 206 37 two two NUM bam-8931 206 38 randomised randomised ADJ bam-8931 206 39 , , PUNCT bam-8931 206 40 double double ADJ bam-8931 206 41 - - PUNCT bam-8931 206 42 blind blind ADJ bam-8931 206 43 , , PUNCT bam-8931 206 44 phase phase NOUN bam-8931 206 45 3 3 NUM bam-8931 206 46 trials trial NOUN bam-8931 206 47 . . PUNCT bam-8931 207 1 lancet lancet VERB bam-8931 207 2 oncol oncol ADJ bam-8931 207 3 2016;17:519 2016;17:519 PROPN bam-8931 207 4 - - SYM bam-8931 207 5 31 31 NUM bam-8931 207 6 . . NOUN bam-8931 207 7 8 8 NUM bam-8931 207 8 . . PUNCT bam-8931 208 1 argiles argiles PROPN bam-8931 208 2 jm jm PROPN bam-8931 208 3 , , PUNCT bam-8931 208 4 lopez lopez PROPN bam-8931 208 5 - - PUNCT bam-8931 208 6 soriano soriano PROPN bam-8931 208 7 fj fj PROPN bam-8931 208 8 . . PUNCT bam-8931 209 1 the the DET bam-8931 209 2 role role NOUN bam-8931 209 3 of of ADP bam-8931 209 4 cytokines cytokine NOUN bam-8931 209 5 in in ADP bam-8931 209 6 cancer cancer NOUN bam-8931 209 7 cachexia cachexia NOUN bam-8931 209 8 . . PUNCT bam-8931 210 1 med med PROPN bam-8931 210 2 res re NOUN bam-8931 210 3 rev rev PROPN bam-8931 210 4 1999;19:223 1999;19:223 PROPN bam-8931 210 5 - - SYM bam-8931 210 6 48 48 NUM bam-8931 210 7 . . PUNCT bam-8931 211 1 9 9 NUM bam-8931 211 2 . . X bam-8931 211 3 reid reid PROPN bam-8931 211 4 mb mb PROPN bam-8931 211 5 , , PUNCT bam-8931 211 6 li li PROPN bam-8931 211 7 yp yp PROPN bam-8931 211 8 . . PROPN bam-8931 211 9 tumor tumor NOUN bam-8931 211 10 necrosis necrosis NOUN bam-8931 211 11 factor factor NOUN bam-8931 211 12 - - PUNCT bam-8931 211 13 alpha alpha NOUN bam-8931 211 14 and and CCONJ bam-8931 211 15 muscle muscle NOUN bam-8931 211 16 wasting waste VERB bam-8931 211 17 : : PUNCT bam-8931 211 18 a a DET bam-8931 211 19 cellular cellular ADJ bam-8931 211 20 perspective perspective NOUN bam-8931 211 21 . . PUNCT bam-8931 212 1 respir respir VERB bam-8931 212 2 res re NOUN bam-8931 212 3 2001;2:269 2001;2:269 NOUN bam-8931 212 4 - - SYM bam-8931 212 5 72 72 NUM bam-8931 212 6 . . PUNCT bam-8931 213 1 10 10 NUM bam-8931 213 2 . . PUNCT bam-8931 214 1 rennie rennie PROPN bam-8931 214 2 mj mj PROPN bam-8931 214 3 , , PUNCT bam-8931 214 4 wackerhage wackerhage NOUN bam-8931 214 5 h h PROPN bam-8931 214 6 , , PUNCT bam-8931 214 7 spangenburg spangenburg PROPN bam-8931 214 8 ee ee PROPN bam-8931 214 9 , , PUNCT bam-8931 214 10 booth booth PROPN bam-8931 214 11 fw fw PROPN bam-8931 214 12 . . PROPN bam-8931 214 13 control control NOUN bam-8931 214 14 of of ADP bam-8931 214 15 the the DET bam-8931 214 16 size size NOUN bam-8931 214 17 of of ADP bam-8931 214 18 the the DET bam-8931 214 19 human human ADJ bam-8931 214 20 muscle muscle NOUN bam-8931 214 21 mass mass PROPN bam-8931 214 22 . . PUNCT bam-8931 214 23 annu annu PROPN bam-8931 214 24 rev rev PROPN bam-8931 214 25 physiol physiol PROPN bam-8931 214 26 2004;66:799 2004;66:799 PROPN bam-8931 214 27 - - PUNCT bam-8931 214 28 828 828 NUM bam-8931 214 29 . . PUNCT bam-8931 215 1 11 11 NUM bam-8931 215 2 . . PUNCT bam-8931 216 1 tisdale tisdale PROPN bam-8931 216 2 mj mj PROPN bam-8931 216 3 . . PUNCT bam-8931 217 1 molecular molecular ADJ bam-8931 217 2 pathways pathway NOUN bam-8931 217 3 leading lead VERB bam-8931 217 4 to to ADP bam-8931 217 5 cancer cancer NOUN bam-8931 217 6 cachexia cachexia NOUN bam-8931 217 7 . . PUNCT bam-8931 218 1 physiology physiology NOUN bam-8931 218 2 ( ( PUNCT bam-8931 218 3 bethesda bethesda PROPN bam-8931 218 4 ) ) PUNCT bam-8931 218 5 2005;20:340 2005;20:340 NUM bam-8931 218 6 - - SYM bam-8931 218 7 8 8 NUM bam-8931 218 8 . . NOUN bam-8931 218 9 12 12 NUM bam-8931 218 10 . . PUNCT bam-8931 219 1 zhao zhao PROPN bam-8931 219 2 j j PROPN bam-8931 219 3 , , PUNCT bam-8931 219 4 brault brault NOUN bam-8931 219 5 jj jj PROPN bam-8931 219 6 , , PUNCT bam-8931 219 7 schild schild NOUN bam-8931 219 8 a a PROPN bam-8931 219 9 , , PUNCT bam-8931 219 10 et et PROPN bam-8931 219 11 al al PROPN bam-8931 219 12 . . PUNCT bam-8931 219 13 foxo3 foxo3 PROPN bam-8931 219 14 coordinately coordinately ADV bam-8931 219 15 activates activate VERB bam-8931 219 16 protein protein NOUN bam-8931 219 17 degradation degradation NOUN bam-8931 219 18 by by ADP bam-8931 219 19 the the DET bam-8931 219 20 autophagic autophagic PROPN bam-8931 219 21 / / SYM bam-8931 219 22 lysosomal lysosomal ADJ bam-8931 219 23 and and CCONJ bam-8931 219 24 proteasomal proteasomal ADJ bam-8931 219 25 pathways pathway NOUN bam-8931 219 26 in in ADP bam-8931 219 27 atrophying atrophy VERB bam-8931 219 28 muscle muscle NOUN bam-8931 219 29 cells cell NOUN bam-8931 219 30 . . PUNCT bam-8931 220 1 cell cell NOUN bam-8931 220 2 metab metab PROPN bam-8931 220 3 2007;6:472 2007;6:472 NOUN bam-8931 220 4 - - SYM bam-8931 220 5 83 83 NUM bam-8931 220 6 . . PUNCT bam-8931 221 1 13 13 NUM bam-8931 221 2 . . PUNCT bam-8931 222 1 farges farges PROPN bam-8931 222 2 mc mc PROPN bam-8931 222 3 , , PUNCT bam-8931 222 4 balcerzak balcerzak PROPN bam-8931 222 5 d d PROPN bam-8931 222 6 , , PUNCT bam-8931 222 7 fisher fisher PROPN bam-8931 222 8 bd bd PROPN bam-8931 222 9 , , PUNCT bam-8931 222 10 et et PROPN bam-8931 222 11 al al PROPN bam-8931 222 12 . . PROPN bam-8931 222 13 increased increase VERB bam-8931 222 14 muscle muscle NOUN bam-8931 222 15 proteolysis proteolysis NOUN bam-8931 222 16 after after ADP bam-8931 222 17 local local ADJ bam-8931 222 18 trauma trauma NOUN bam-8931 222 19 mainly mainly ADV bam-8931 222 20 reflects reflect VERB bam-8931 222 21 macrophage macrophage ADJ bam-8931 222 22 - - PUNCT bam-8931 222 23 associated associate VERB bam-8931 222 24 lysosomal lysosomal ADJ bam-8931 222 25 proteolysis proteolysis NOUN bam-8931 222 26 . . PUNCT bam-8931 223 1 am be AUX bam-8931 223 2 j j PROPN bam-8931 223 3 physiol physiol PROPN bam-8931 223 4 endocrinol endocrinol VERB bam-8931 223 5 metab metab PROPN bam-8931 223 6 2002;282 2002;282 NUM bam-8931 223 7 : : PUNCT bam-8931 223 8 e326 e326 NUM bam-8931 223 9 - - SYM bam-8931 223 10 35 35 NUM bam-8931 223 11 . . PUNCT bam-8931 224 1 mailto:stefania.dalise@ao-pisa.toscana.it mailto:stefania.dalise@ao-pisa.toscana.it NOUN bam-8931 224 2 muscle muscle NOUN bam-8931 224 3 impairment impairment NOUN bam-8931 224 4 in in ADP bam-8931 224 5 pre pre ADJ bam-8931 224 6 - - ADJ bam-8931 224 7 cachexia cachexia ADJ bam-8931 224 8 cancer cancer NOUN bam-8931 224 9 patients patient NOUN bam-8931 224 10 eur eur PROPN bam-8931 224 11 j j PROPN bam-8931 224 12 transl transl PROPN bam-8931 224 13 myol myol ADV bam-8931 224 14 30 30 NUM bam-8931 224 15 ( ( PUNCT bam-8931 224 16 2 2 NUM bam-8931 224 17 ): ): PUNCT bam-8931 224 18 258 258 NUM bam-8931 224 19 - - SYM bam-8931 224 20 267 267 NUM bam-8931 224 21 , , PUNCT bam-8931 224 22 2020 2020 NUM bam-8931 224 23 266 266 NUM bam-8931 224 24 14 14 NUM bam-8931 224 25 . . PUNCT bam-8931 225 1 hasselgren hasselgren PROPN bam-8931 225 2 po po PROPN bam-8931 225 3 , , PUNCT bam-8931 225 4 fischer fischer PROPN bam-8931 225 5 je je PROPN bam-8931 225 6 . . PROPN bam-8931 225 7 muscle muscle PROPN bam-8931 225 8 cachexia cachexia PROPN bam-8931 225 9 : : PUNCT bam-8931 225 10 current current ADJ bam-8931 225 11 concepts concept NOUN bam-8931 225 12 of of ADP bam-8931 225 13 intracellular intracellular ADJ bam-8931 225 14 mechanisms mechanism NOUN bam-8931 225 15 and and CCONJ bam-8931 225 16 molecular molecular ADJ bam-8931 225 17 regulation regulation NOUN bam-8931 225 18 . . PUNCT bam-8931 226 1 ann ann PROPN bam-8931 226 2 surg surg PROPN bam-8931 226 3 2001;233:9 2001;233:9 PROPN bam-8931 226 4 - - SYM bam-8931 226 5 17 17 NUM bam-8931 226 6 . . PUNCT bam-8931 226 7 15 15 NUM bam-8931 226 8 . . PUNCT bam-8931 227 1 jackman jackman PROPN bam-8931 227 2 rw rw PROPN bam-8931 227 3 , , PUNCT bam-8931 227 4 kandarian kandarian PROPN bam-8931 227 5 sc sc PROPN bam-8931 227 6 . . PUNCT bam-8931 228 1 the the DET bam-8931 228 2 molecular molecular ADJ bam-8931 228 3 basis basis NOUN bam-8931 228 4 of of ADP bam-8931 228 5 skeletal skeletal ADJ bam-8931 228 6 muscle muscle NOUN bam-8931 228 7 atrophy atrophy NOUN bam-8931 228 8 . . PUNCT bam-8931 229 1 am be AUX bam-8931 229 2 j j PROPN bam-8931 229 3 physiol physiol PROPN bam-8931 229 4 cell cell PROPN bam-8931 229 5 physiol physiol PROPN bam-8931 229 6 2004;287 2004;287 NUM bam-8931 229 7 : : PUNCT bam-8931 229 8 c834 c834 NUM bam-8931 229 9 - - SYM bam-8931 229 10 43 43 NUM bam-8931 229 11 . . PUNCT bam-8931 230 1 16 16 NUM bam-8931 230 2 . . PUNCT bam-8931 231 1 lecker lecker PROPN bam-8931 231 2 sh sh PROPN bam-8931 231 3 , , PUNCT bam-8931 231 4 solomon solomon PROPN bam-8931 231 5 v v PROPN bam-8931 231 6 , , PUNCT bam-8931 231 7 mitch mitch PROPN bam-8931 231 8 we we PRON bam-8931 231 9 , , PUNCT bam-8931 231 10 goldberg goldberg PROPN bam-8931 231 11 al al PROPN bam-8931 231 12 . . PROPN bam-8931 231 13 muscle muscle NOUN bam-8931 231 14 protein protein NOUN bam-8931 231 15 breakdown breakdown NOUN bam-8931 231 16 and and CCONJ bam-8931 231 17 the the DET bam-8931 231 18 critical critical ADJ bam-8931 231 19 role role NOUN bam-8931 231 20 of of ADP bam-8931 231 21 the the DET bam-8931 231 22 ubiquitin ubiquitin ADJ bam-8931 231 23 - - PUNCT bam-8931 231 24 proteasome proteasome NOUN bam-8931 231 25 pathway pathway NOUN bam-8931 231 26 in in ADP bam-8931 231 27 normal normal ADJ bam-8931 231 28 and and CCONJ bam-8931 231 29 disease disease NOUN bam-8931 231 30 states state VERB bam-8931 231 31 j j PROPN bam-8931 231 32 nutr nutr PROPN bam-8931 231 33 1999;129:227s-37s 1999;129:227s-37s NUM bam-8931 231 34 . . PROPN bam-8931 231 35 17 17 NUM bam-8931 231 36 . . PUNCT bam-8931 232 1 temparis temparis PROPN bam-8931 232 2 s s PROPN bam-8931 232 3 , , PUNCT bam-8931 232 4 asensi asensi PROPN bam-8931 232 5 m m PRON bam-8931 232 6 , , PUNCT bam-8931 232 7 taillandier taillandi ADJ bam-8931 232 8 d d NOUN bam-8931 232 9 , , PUNCT bam-8931 232 10 et et PROPN bam-8931 232 11 al al PROPN bam-8931 232 12 . . PROPN bam-8931 232 13 increased increase VERB bam-8931 232 14 atp atp PROPN bam-8931 232 15 - - PUNCT bam-8931 232 16 ubiquitin ubiquitin ADJ bam-8931 232 17 - - PUNCT bam-8931 232 18 dependent dependent ADJ bam-8931 232 19 proteolysis proteolysis NOUN bam-8931 232 20 in in ADP bam-8931 232 21 skeletal skeletal ADJ bam-8931 232 22 muscles muscle NOUN bam-8931 232 23 of of ADP bam-8931 232 24 tumor tumor NOUN bam-8931 232 25 - - PUNCT bam-8931 232 26 bearing bear VERB bam-8931 232 27 rats rat NOUN bam-8931 232 28 . . PUNCT bam-8931 233 1 cancer cancer NOUN bam-8931 233 2 res re NOUN bam-8931 233 3 1994;54:5568 1994;54:5568 NUM bam-8931 233 4 - - SYM bam-8931 233 5 73 73 NUM bam-8931 233 6 . . PUNCT bam-8931 234 1 18 18 NUM bam-8931 234 2 . . PUNCT bam-8931 235 1 williams williams PROPN bam-8931 235 2 a a PROPN bam-8931 235 3 , , PUNCT bam-8931 235 4 sun sun PROPN bam-8931 235 5 x x SYM bam-8931 235 6 , , PUNCT bam-8931 235 7 fischer fischer PROPN bam-8931 235 8 je je PROPN bam-8931 235 9 , , PUNCT bam-8931 235 10 hasselgren hasselgren PROPN bam-8931 235 11 po po PROPN bam-8931 235 12 . . PUNCT bam-8931 236 1 the the DET bam-8931 236 2 expression expression NOUN bam-8931 236 3 of of ADP bam-8931 236 4 genes gene NOUN bam-8931 236 5 in in ADP bam-8931 236 6 the the DET bam-8931 236 7 ubiquitin ubiquitin ADJ bam-8931 236 8 - - PUNCT bam-8931 236 9 proteasome proteasome ADJ bam-8931 236 10 proteolytic proteolytic ADJ bam-8931 236 11 pathway pathway NOUN bam-8931 236 12 is be AUX bam-8931 236 13 increased increase VERB bam-8931 236 14 in in ADP bam-8931 236 15 skeletal skeletal ADJ bam-8931 236 16 muscle muscle NOUN bam-8931 236 17 from from ADP bam-8931 236 18 patients patient NOUN bam-8931 236 19 with with ADP bam-8931 236 20 cancer cancer NOUN bam-8931 236 21 . . PUNCT bam-8931 237 1 surgery surgery NOUN bam-8931 237 2 1999;126:744 1999;126:744 NUM bam-8931 237 3 - - SYM bam-8931 237 4 9 9 NUM bam-8931 237 5 ; ; PUNCT bam-8931 237 6 discussion discussion NOUN bam-8931 237 7 9 9 NUM bam-8931 237 8 - - SYM bam-8931 237 9 50 50 NUM bam-8931 237 10 . . PUNCT bam-8931 237 11 19 19 NUM bam-8931 237 12 . . PUNCT bam-8931 237 13 bodine bodine PROPN bam-8931 237 14 sc sc PROPN bam-8931 237 15 , , PUNCT bam-8931 237 16 latres latre NOUN bam-8931 237 17 e e PROPN bam-8931 237 18 , , PUNCT bam-8931 237 19 baumhueter baumhueter PROPN bam-8931 237 20 s s PROPN bam-8931 237 21 , , PUNCT bam-8931 237 22 et et PROPN bam-8931 237 23 al al PROPN bam-8931 237 24 . . PUNCT bam-8931 237 25 identification identification NOUN bam-8931 237 26 of of ADP bam-8931 237 27 ubiquitin ubiquitin ADJ bam-8931 237 28 ligases ligase NOUN bam-8931 237 29 required require VERB bam-8931 237 30 for for ADP bam-8931 237 31 skeletal skeletal ADJ bam-8931 237 32 muscle muscle NOUN bam-8931 237 33 atrophy atrophy NOUN bam-8931 237 34 . . PUNCT bam-8931 238 1 science science NOUN bam-8931 238 2 2001;294:1704 2001;294:1704 NUM bam-8931 238 3 - - SYM bam-8931 238 4 8 8 NUM bam-8931 238 5 . . NOUN bam-8931 238 6 20 20 NUM bam-8931 238 7 . . PUNCT bam-8931 239 1 gomes gomes PROPN bam-8931 239 2 md md PROPN bam-8931 239 3 , , PUNCT bam-8931 239 4 lecker lecker PROPN bam-8931 239 5 sh sh PROPN bam-8931 239 6 , , PUNCT bam-8931 239 7 jagoe jagoe PROPN bam-8931 239 8 rt rt PROPN bam-8931 239 9 , , PUNCT bam-8931 239 10 et et PROPN bam-8931 239 11 al al PROPN bam-8931 239 12 . . PROPN bam-8931 239 13 atrogin-1 atrogin-1 PROPN bam-8931 239 14 , , PUNCT bam-8931 239 15 a a DET bam-8931 239 16 muscle muscle NOUN bam-8931 239 17 - - PUNCT bam-8931 239 18 specific specific ADJ bam-8931 239 19 f f PROPN bam-8931 239 20 - - PUNCT bam-8931 239 21 box box NOUN bam-8931 239 22 protein protein NOUN bam-8931 239 23 highly highly ADV bam-8931 239 24 expressed express VERB bam-8931 239 25 during during ADP bam-8931 239 26 muscle muscle NOUN bam-8931 239 27 atrophy atrophy NOUN bam-8931 239 28 . . PUNCT bam-8931 240 1 proc proc PROPN bam-8931 240 2 natl natl PROPN bam-8931 240 3 acad acad PROPN bam-8931 240 4 sci sci PROPN bam-8931 240 5 u u PROPN bam-8931 240 6 s s PROPN bam-8931 240 7 a a DET bam-8931 240 8 2001;98:14440 2001;98:14440 PROPN bam-8931 240 9 - - SYM bam-8931 240 10 5 5 NUM bam-8931 240 11 . . NOUN bam-8931 240 12 21 21 NUM bam-8931 240 13 . . PUNCT bam-8931 241 1 glass glass NOUN bam-8931 241 2 dj dj NOUN bam-8931 241 3 . . PUNCT bam-8931 242 1 signalling signal VERB bam-8931 242 2 pathways pathway NOUN bam-8931 242 3 that that PRON bam-8931 242 4 mediate mediate VERB bam-8931 242 5 skeletal skeletal ADJ bam-8931 242 6 muscle muscle NOUN bam-8931 242 7 hypertrophy hypertrophy NOUN bam-8931 242 8 and and CCONJ bam-8931 242 9 atrophy atrophy NOUN bam-8931 242 10 . . PUNCT bam-8931 243 1 nat nat NOUN bam-8931 243 2 cell cell NOUN bam-8931 243 3 biol biol PROPN bam-8931 243 4 2003;5:87 2003;5:87 NOUN bam-8931 243 5 - - PUNCT bam-8931 243 6 90 90 NUM bam-8931 243 7 . . PUNCT bam-8931 243 8 22 22 NUM bam-8931 243 9 . . PUNCT bam-8931 244 1 jackman jackman PROPN bam-8931 244 2 rw rw PROPN bam-8931 244 3 , , PUNCT bam-8931 244 4 kandarian kandarian PROPN bam-8931 244 5 sc sc PROPN bam-8931 244 6 . . PUNCT bam-8931 245 1 the the DET bam-8931 245 2 molecular molecular ADJ bam-8931 245 3 basis basis NOUN bam-8931 245 4 of of ADP bam-8931 245 5 skeletal skeletal ADJ bam-8931 245 6 muscle muscle NOUN bam-8931 245 7 atrophy atrophy NOUN bam-8931 245 8 . . PUNCT bam-8931 246 1 american american ADJ bam-8931 246 2 journal journal PROPN bam-8931 246 3 of of ADP bam-8931 246 4 physiology physiology NOUN bam-8931 246 5 cell cell NOUN bam-8931 246 6 physiology physiology NOUN bam-8931 246 7 2004;287 2004;287 NUM bam-8931 246 8 : : PUNCT bam-8931 246 9 c834 c834 PROPN bam-8931 246 10 - - PUNCT bam-8931 246 11 c43 c43 PROPN bam-8931 246 12 . . PROPN bam-8931 246 13 23 23 NUM bam-8931 246 14 . . PUNCT bam-8931 247 1 aulino aulino PROPN bam-8931 247 2 p p X bam-8931 247 3 , , PUNCT bam-8931 247 4 berardi berardi PROPN bam-8931 247 5 e e PROPN bam-8931 247 6 , , PUNCT bam-8931 247 7 cardillo cardillo PROPN bam-8931 247 8 vm vm PROPN bam-8931 247 9 , , PUNCT bam-8931 247 10 et et PROPN bam-8931 247 11 al al PROPN bam-8931 247 12 . . PUNCT bam-8931 248 1 molecular molecular ADJ bam-8931 248 2 , , PUNCT bam-8931 248 3 cellular cellular ADJ bam-8931 248 4 and and CCONJ bam-8931 248 5 physiological physiological ADJ bam-8931 248 6 characterization characterization NOUN bam-8931 248 7 of of ADP bam-8931 248 8 the the DET bam-8931 248 9 cancer cancer NOUN bam-8931 248 10 cachexia cachexia NOUN bam-8931 248 11 - - PUNCT bam-8931 248 12 inducing induce VERB bam-8931 248 13 c26 c26 NOUN bam-8931 248 14 colon colon NOUN bam-8931 248 15 carcinoma carcinoma NOUN bam-8931 248 16 in in ADP bam-8931 248 17 mouse mouse NOUN bam-8931 248 18 . . PUNCT bam-8931 249 1 bmc bmc ADJ bam-8931 249 2 cancer cancer NOUN bam-8931 249 3 2010;10:363 2010;10:363 PROPN bam-8931 249 4 . . PROPN bam-8931 249 5 24 24 NUM bam-8931 249 6 . . PUNCT bam-8931 249 7 holmes holmes PROPN bam-8931 249 8 md md PROPN bam-8931 249 9 , , PUNCT bam-8931 249 10 chen chen PROPN bam-8931 249 11 wy wy PROPN bam-8931 249 12 , , PUNCT bam-8931 249 13 feskanich feskanich PROPN bam-8931 250 1 d d PROPN bam-8931 250 2 , , PUNCT bam-8931 250 3 et et PROPN bam-8931 250 4 al al PROPN bam-8931 250 5 . . PROPN bam-8931 250 6 physical physical ADJ bam-8931 250 7 activity activity NOUN bam-8931 250 8 and and CCONJ bam-8931 250 9 survival survival NOUN bam-8931 250 10 after after ADP bam-8931 250 11 breast breast NOUN bam-8931 250 12 cancer cancer NOUN bam-8931 250 13 diagnosis diagnosis NOUN bam-8931 250 14 . . PUNCT bam-8931 251 1 jama jama PROPN bam-8931 251 2 2005;293:2479 2005;293:2479 NUM bam-8931 251 3 - - SYM bam-8931 251 4 86 86 NUM bam-8931 251 5 . . PUNCT bam-8931 252 1 25 25 NUM bam-8931 252 2 . . PUNCT bam-8931 252 3 meyerhardt meyerhardt PROPN bam-8931 252 4 ja ja PROPN bam-8931 252 5 , , PUNCT bam-8931 252 6 giovannucci giovannucci PROPN bam-8931 252 7 el el PROPN bam-8931 252 8 , , PUNCT bam-8931 252 9 holmes holmes PROPN bam-8931 252 10 md md PROPN bam-8931 252 11 , , PUNCT bam-8931 252 12 et et PROPN bam-8931 252 13 al al PROPN bam-8931 252 14 . . PROPN bam-8931 252 15 physical physical ADJ bam-8931 252 16 activity activity NOUN bam-8931 252 17 and and CCONJ bam-8931 252 18 survival survival NOUN bam-8931 252 19 after after ADP bam-8931 252 20 colorectal colorectal ADJ bam-8931 252 21 cancer cancer NOUN bam-8931 252 22 diagnosis diagnosis NOUN bam-8931 252 23 . . PUNCT bam-8931 253 1 j j PROPN bam-8931 253 2 clin clin PROPN bam-8931 253 3 oncol oncol PROPN bam-8931 253 4 2006;24:3527 2006;24:3527 PROPN bam-8931 253 5 - - SYM bam-8931 253 6 34 34 NUM bam-8931 253 7 . . PROPN bam-8931 253 8 26 26 NUM bam-8931 253 9 . . PUNCT bam-8931 254 1 irwin irwin PROPN bam-8931 254 2 ml ml PROPN bam-8931 254 3 , , PUNCT bam-8931 254 4 smith smith PROPN bam-8931 254 5 aw aw INTJ bam-8931 254 6 , , PUNCT bam-8931 254 7 mctiernan mctiernan PROPN bam-8931 254 8 a a PROPN bam-8931 254 9 , , PUNCT bam-8931 254 10 et et PROPN bam-8931 254 11 al al PROPN bam-8931 254 12 . . PUNCT bam-8931 254 13 influence influence NOUN bam-8931 254 14 of of ADP bam-8931 254 15 preand preand NOUN bam-8931 254 16 postdiagnosis postdiagnosis NOUN bam-8931 254 17 physical physical ADJ bam-8931 254 18 activity activity NOUN bam-8931 254 19 on on ADP bam-8931 254 20 mortality mortality NOUN bam-8931 254 21 in in ADP bam-8931 254 22 breast breast NOUN bam-8931 254 23 cancer cancer NOUN bam-8931 254 24 survivors survivor NOUN bam-8931 254 25 : : PUNCT bam-8931 254 26 the the DET bam-8931 254 27 health health NOUN bam-8931 254 28 , , PUNCT bam-8931 254 29 eating eating NOUN bam-8931 254 30 , , PUNCT bam-8931 254 31 activity activity NOUN bam-8931 254 32 , , PUNCT bam-8931 254 33 and and CCONJ bam-8931 254 34 lifestyle lifestyle NOUN bam-8931 254 35 study study NOUN bam-8931 254 36 . . PUNCT bam-8931 255 1 j j PROPN bam-8931 255 2 clin clin PROPN bam-8931 255 3 oncol oncol PROPN bam-8931 255 4 2008;26:3958 2008;26:3958 NUM bam-8931 255 5 - - SYM bam-8931 255 6 64 64 NUM bam-8931 255 7 . . PUNCT bam-8931 255 8 27 27 NUM bam-8931 255 9 . . PUNCT bam-8931 256 1 fearon fearon PROPN bam-8931 256 2 k k PROPN bam-8931 256 3 , , PUNCT bam-8931 256 4 strasser strasser PROPN bam-8931 256 5 f f PROPN bam-8931 256 6 , , PUNCT bam-8931 256 7 anker anker PROPN bam-8931 256 8 sd sd PROPN bam-8931 256 9 , , PUNCT bam-8931 256 10 et et PROPN bam-8931 256 11 al al PROPN bam-8931 256 12 . . PUNCT bam-8931 257 1 definition definition NOUN bam-8931 257 2 and and CCONJ bam-8931 257 3 classification classification NOUN bam-8931 257 4 of of ADP bam-8931 257 5 cancer cancer NOUN bam-8931 257 6 cachexia cachexia NOUN bam-8931 257 7 : : PUNCT bam-8931 257 8 an an DET bam-8931 257 9 international international ADJ bam-8931 257 10 consensus consensus NOUN bam-8931 257 11 . . PUNCT bam-8931 258 1 lancet lancet PROPN bam-8931 258 2 oncol oncol ADJ bam-8931 258 3 2011;12:489 2011;12:489 PROPN bam-8931 258 4 - - SYM bam-8931 258 5 95 95 NUM bam-8931 258 6 . . PUNCT bam-8931 259 1 28 28 NUM bam-8931 259 2 . . PUNCT bam-8931 260 1 cupisti cupisti PROPN bam-8931 260 2 a a PRON bam-8931 260 3 , , PUNCT bam-8931 260 4 licitra licitra ADJ bam-8931 260 5 r r NOUN bam-8931 260 6 , , PUNCT bam-8931 260 7 chisari chisari ADJ bam-8931 260 8 c c NOUN bam-8931 260 9 , , PUNCT bam-8931 260 10 et et PROPN bam-8931 260 11 al al PROPN bam-8931 260 12 . . PROPN bam-8931 260 13 skeletal skeletal ADJ bam-8931 260 14 muscle muscle NOUN bam-8931 260 15 and and CCONJ bam-8931 260 16 nutritional nutritional ADJ bam-8931 260 17 assessment assessment NOUN bam-8931 260 18 in in ADP bam-8931 260 19 chronic chronic ADJ bam-8931 260 20 renal renal ADJ bam-8931 260 21 failure failure NOUN bam-8931 260 22 patients patient NOUN bam-8931 260 23 on on ADP bam-8931 260 24 a a DET bam-8931 260 25 protein protein NOUN bam-8931 260 26 - - PUNCT bam-8931 260 27 restricted restrict VERB bam-8931 260 28 diet diet NOUN bam-8931 260 29 . . PUNCT bam-8931 261 1 j j PROPN bam-8931 261 2 intern intern PROPN bam-8931 261 3 med me VERB bam-8931 261 4 2004;255:115 2004;255:115 PROPN bam-8931 261 5 - - SYM bam-8931 261 6 24 24 NUM bam-8931 261 7 . . PUNCT bam-8931 261 8 29 29 NUM bam-8931 261 9 . . PUNCT bam-8931 262 1 bertolucci bertolucci PROPN bam-8931 262 2 f f PROPN bam-8931 262 3 , , PUNCT bam-8931 262 4 neri neri PROPN bam-8931 262 5 r r NOUN bam-8931 262 6 , , PUNCT bam-8931 262 7 dalise dalise PROPN bam-8931 262 8 s s PROPN bam-8931 262 9 , , PUNCT bam-8931 262 10 et et PROPN bam-8931 262 11 al al PROPN bam-8931 262 12 . . PROPN bam-8931 262 13 abnormal abnormal ADJ bam-8931 262 14 lactate lactate NOUN bam-8931 262 15 levels level NOUN bam-8931 262 16 in in ADP bam-8931 262 17 patients patient NOUN bam-8931 262 18 with with ADP bam-8931 262 19 polymyositis polymyositis PROPN bam-8931 262 20 and and CCONJ bam-8931 262 21 dermatomyositis dermatomyositis PROPN bam-8931 262 22 : : PUNCT bam-8931 262 23 the the DET bam-8931 262 24 benefits benefit NOUN bam-8931 262 25 of of ADP bam-8931 262 26 a a DET bam-8931 262 27 specific specific ADJ bam-8931 262 28 rehabilitative rehabilitative ADJ bam-8931 262 29 program program NOUN bam-8931 262 30 . . PUNCT bam-8931 263 1 eur eur PROPN bam-8931 263 2 j j PROPN bam-8931 263 3 phys phy NOUN bam-8931 263 4 rehabil rehabil VERB bam-8931 263 5 med med PROPN bam-8931 263 6 2013 2013 NUM bam-8931 263 7 . . PUNCT bam-8931 264 1 30 30 NUM bam-8931 264 2 . . PUNCT bam-8931 265 1 pimentel pimentel PROPN bam-8931 265 2 ae ae PROPN bam-8931 265 3 , , PUNCT bam-8931 265 4 gentile gentile NOUN bam-8931 265 5 cl cl NOUN bam-8931 265 6 , , PUNCT bam-8931 265 7 tanaka tanaka PROPN bam-8931 265 8 h h PROPN bam-8931 265 9 , , PUNCT bam-8931 265 10 et et PROPN bam-8931 265 11 al al PROPN bam-8931 265 12 . . PUNCT bam-8931 266 1 greater great ADJ bam-8931 266 2 rate rate NOUN bam-8931 266 3 of of ADP bam-8931 266 4 decline decline NOUN bam-8931 266 5 in in ADP bam-8931 266 6 maximal maximal ADJ bam-8931 266 7 aerobic aerobic ADJ bam-8931 266 8 capacity capacity NOUN bam-8931 266 9 with with ADP bam-8931 266 10 age age NOUN bam-8931 266 11 in in ADP bam-8931 266 12 endurance endurance NOUN bam-8931 266 13 - - PUNCT bam-8931 266 14 trained train VERB bam-8931 266 15 than than ADP bam-8931 266 16 in in ADP bam-8931 266 17 sedentary sedentary ADJ bam-8931 266 18 men man NOUN bam-8931 266 19 . . PUNCT bam-8931 267 1 j j PROPN bam-8931 267 2 appl appl PROPN bam-8931 267 3 physiol physiol PROPN bam-8931 267 4 ( ( PUNCT bam-8931 267 5 1985 1985 NUM bam-8931 267 6 ) ) PUNCT bam-8931 267 7 2003;94:2406 2003;94:2406 NUM bam-8931 267 8 - - SYM bam-8931 267 9 13 13 NUM bam-8931 267 10 . . PUNCT bam-8931 268 1 31 31 NUM bam-8931 268 2 . . PUNCT bam-8931 269 1 shechtman shechtman NOUN bam-8931 269 2 o. o. PROPN bam-8931 269 3 the the DET bam-8931 269 4 coefficient coefficient NOUN bam-8931 269 5 of of ADP bam-8931 269 6 variation variation NOUN bam-8931 269 7 as as ADP bam-8931 269 8 a a DET bam-8931 269 9 measure measure NOUN bam-8931 269 10 of of ADP bam-8931 269 11 sincerity sincerity NOUN bam-8931 269 12 of of ADP bam-8931 269 13 effort effort NOUN bam-8931 269 14 of of ADP bam-8931 269 15 grip grip NOUN bam-8931 269 16 strength strength NOUN bam-8931 269 17 , , PUNCT bam-8931 269 18 part part PROPN bam-8931 269 19 ii ii PROPN bam-8931 269 20 : : PUNCT bam-8931 269 21 sensitivity sensitivity NOUN bam-8931 269 22 and and CCONJ bam-8931 269 23 specificity specificity NOUN bam-8931 269 24 . . PUNCT bam-8931 270 1 j j PROPN bam-8931 270 2 hand hand NOUN bam-8931 270 3 ther ther ADV bam-8931 270 4 2001;14:188 2001;14:188 NOUN bam-8931 270 5 - - SYM bam-8931 270 6 94 94 NUM bam-8931 270 7 . . PUNCT bam-8931 271 1 32 32 NUM bam-8931 271 2 . . PUNCT bam-8931 272 1 kirk kirk PROPN bam-8931 272 2 r. r. PROPN bam-8931 272 3 experimental experimental PROPN bam-8931 272 4 design design PROPN bam-8931 272 5 : : PUNCT bam-8931 272 6 procedures procedure NOUN bam-8931 272 7 for for ADP bam-8931 272 8 the the DET bam-8931 272 9 behavioral behavioral ADJ bam-8931 272 10 sciences science NOUN bam-8931 272 11 . . PUNCT bam-8931 273 1 second second ADJ bam-8931 273 2 ed ed NOUN bam-8931 273 3 . . PUNCT bam-8931 274 1 monterey monterey PROPN bam-8931 274 2 , , PUNCT bam-8931 274 3 calif calif PROPN bam-8931 274 4 : : PUNCT bam-8931 274 5 brooks brooks PROPN bam-8931 274 6 / / SYM bam-8931 274 7 cole cole PROPN bam-8931 274 8 pub pub NOUN bam-8931 274 9 . . PUNCT bam-8931 275 1 co co NOUN bam-8931 275 2 ; ; PUNCT bam-8931 275 3 1982 1982 NUM bam-8931 275 4 . . PUNCT bam-8931 276 1 33 33 NUM bam-8931 276 2 . . X bam-8931 277 1 fouladiun fouladiun PROPN bam-8931 277 2 m m PROPN bam-8931 277 3 , , PUNCT bam-8931 277 4 korner korner PROPN bam-8931 277 5 u u PROPN bam-8931 277 6 , , PUNCT bam-8931 277 7 gunnebo gunnebo PROPN bam-8931 277 8 l l PROPN bam-8931 277 9 , , PUNCT bam-8931 277 10 et et PROPN bam-8931 277 11 al al PROPN bam-8931 277 12 . . PROPN bam-8931 277 13 daily daily ADJ bam-8931 277 14 physical physical ADJ bam-8931 277 15 - - PUNCT bam-8931 277 16 rest rest NOUN bam-8931 277 17 activities activity NOUN bam-8931 277 18 in in ADP bam-8931 277 19 relation relation NOUN bam-8931 277 20 to to ADP bam-8931 277 21 nutritional nutritional ADJ bam-8931 277 22 state state NOUN bam-8931 277 23 , , PUNCT bam-8931 277 24 metabolism metabolism NOUN bam-8931 277 25 , , PUNCT bam-8931 277 26 and and CCONJ bam-8931 277 27 quality quality NOUN bam-8931 277 28 of of ADP bam-8931 277 29 life life NOUN bam-8931 277 30 in in ADP bam-8931 277 31 cancer cancer NOUN bam-8931 277 32 patients patient NOUN bam-8931 277 33 with with ADP bam-8931 277 34 progressive progressive ADJ bam-8931 277 35 cachexia cachexia NOUN bam-8931 277 36 . . PUNCT bam-8931 278 1 clin clin PROPN bam-8931 278 2 cancer cancer NOUN bam-8931 278 3 res re VERB bam-8931 278 4 2007;13:6379 2007;13:6379 NUM bam-8931 278 5 - - SYM bam-8931 278 6 85 85 NUM bam-8931 278 7 . . PUNCT bam-8931 279 1 34 34 NUM bam-8931 279 2 . . PUNCT bam-8931 280 1 toledo toledo PROPN bam-8931 280 2 m m PROPN bam-8931 280 3 , , PUNCT bam-8931 280 4 busquets busquets PROPN bam-8931 280 5 s s PART bam-8931 280 6 , , PUNCT bam-8931 280 7 sirisi sirisi PROPN bam-8931 280 8 s s PROPN bam-8931 280 9 , , PUNCT bam-8931 280 10 et et PROPN bam-8931 280 11 al al PROPN bam-8931 280 12 . . PUNCT bam-8931 281 1 cancer cancer NOUN bam-8931 281 2 cachexia cachexia PROPN bam-8931 281 3 : : PUNCT bam-8931 281 4 physical physical ADJ bam-8931 281 5 activity activity NOUN bam-8931 281 6 and and CCONJ bam-8931 281 7 muscle muscle NOUN bam-8931 281 8 force force NOUN bam-8931 281 9 in in ADP bam-8931 281 10 tumour tumour NOUN bam-8931 281 11 - - PUNCT bam-8931 281 12 bearing bear VERB bam-8931 281 13 rats rat NOUN bam-8931 281 14 . . PUNCT bam-8931 282 1 oncol oncol ADJ bam-8931 282 2 rep rep PROPN bam-8931 282 3 2011;25:189 2011;25:189 PROPN bam-8931 282 4 - - SYM bam-8931 282 5 93 93 NUM bam-8931 282 6 . . PUNCT bam-8931 282 7 35 35 NUM bam-8931 282 8 . . PUNCT bam-8931 283 1 al al PROPN bam-8931 283 2 - - PUNCT bam-8931 283 3 majid majid PROPN bam-8931 283 4 s s PROPN bam-8931 283 5 , , PUNCT bam-8931 283 6 mccarthy mccarthy PROPN bam-8931 283 7 do do AUX bam-8931 283 8 . . PUNCT bam-8931 284 1 cancer cancer NOUN bam-8931 284 2 - - PUNCT bam-8931 284 3 induced induce VERB bam-8931 284 4 fatigue fatigue NOUN bam-8931 284 5 and and CCONJ bam-8931 284 6 skeletal skeletal ADJ bam-8931 284 7 muscle muscle NOUN bam-8931 284 8 wasting waste VERB bam-8931 284 9 : : PUNCT bam-8931 284 10 the the DET bam-8931 284 11 role role NOUN bam-8931 284 12 of of ADP bam-8931 284 13 exercise exercise NOUN bam-8931 284 14 . . PUNCT bam-8931 285 1 biol biol PROPN bam-8931 285 2 res res PROPN bam-8931 285 3 nurs nur NOUN bam-8931 285 4 2001;2:186 2001;2:186 NOUN bam-8931 285 5 - - SYM bam-8931 285 6 97 97 NUM bam-8931 285 7 . . PUNCT bam-8931 286 1 36 36 NUM bam-8931 286 2 . . PUNCT bam-8931 287 1 cella cella PROPN bam-8931 287 2 d d PROPN bam-8931 287 3 , , PUNCT bam-8931 287 4 davis davis PROPN bam-8931 287 5 k k PROPN bam-8931 287 6 , , PUNCT bam-8931 287 7 breitbart breitbart PROPN bam-8931 287 8 w w PROPN bam-8931 287 9 , , PUNCT bam-8931 287 10 et et PROPN bam-8931 287 11 al al PROPN bam-8931 287 12 . . PUNCT bam-8931 287 13 cancer cancer NOUN bam-8931 287 14 - - PUNCT bam-8931 287 15 related relate VERB bam-8931 287 16 fatigue fatigue NOUN bam-8931 287 17 : : PUNCT bam-8931 287 18 prevalence prevalence NOUN bam-8931 287 19 of of ADP bam-8931 287 20 proposed propose VERB bam-8931 287 21 diagnostic diagnostic ADJ bam-8931 287 22 criteria criterion NOUN bam-8931 287 23 in in ADP bam-8931 287 24 a a DET bam-8931 287 25 united united PROPN bam-8931 287 26 states states PROPN bam-8931 287 27 sample sample NOUN bam-8931 287 28 of of ADP bam-8931 287 29 cancer cancer NOUN bam-8931 287 30 survivors survivor NOUN bam-8931 287 31 . . PUNCT bam-8931 288 1 j j PROPN bam-8931 288 2 clin clin PROPN bam-8931 288 3 oncol oncol PROPN bam-8931 288 4 2001;19:3385 2001;19:3385 NUM bam-8931 288 5 - - SYM bam-8931 288 6 91 91 NUM bam-8931 288 7 . . PUNCT bam-8931 289 1 37 37 NUM bam-8931 289 2 . . PUNCT bam-8931 290 1 roberts roberts PROPN bam-8931 290 2 bm bm PROPN bam-8931 290 3 , , PUNCT bam-8931 290 4 frye frye PROPN bam-8931 290 5 gs gs PROPN bam-8931 290 6 , , PUNCT bam-8931 290 7 ahn ahn PROPN bam-8931 290 8 b b PROPN bam-8931 290 9 , , PUNCT bam-8931 290 10 et et PROPN bam-8931 290 11 al al PROPN bam-8931 290 12 . . PUNCT bam-8931 291 1 cancer cancer NOUN bam-8931 291 2 cachexia cachexia PROPN bam-8931 291 3 decreases decrease VERB bam-8931 291 4 specific specific ADJ bam-8931 291 5 force force NOUN bam-8931 291 6 and and CCONJ bam-8931 291 7 accelerates accelerate VERB bam-8931 291 8 fatigue fatigue NOUN bam-8931 291 9 in in ADP bam-8931 291 10 limb limb NOUN bam-8931 291 11 muscle muscle NOUN bam-8931 291 12 . . PUNCT bam-8931 292 1 biochem biochem PROPN bam-8931 292 2 biophys biophys PROPN bam-8931 292 3 res res PROPN bam-8931 292 4 commun commun PROPN bam-8931 292 5 2013;435:488 2013;435:488 X bam-8931 292 6 - - SYM bam-8931 292 7 92 92 NUM bam-8931 292 8 . . PUNCT bam-8931 292 9 38 38 NUM bam-8931 292 10 . . PUNCT bam-8931 293 1 khamoui khamoui PROPN bam-8931 293 2 av av PROPN bam-8931 293 3 , , PUNCT bam-8931 293 4 kim kim PROPN bam-8931 293 5 js js PROPN bam-8931 293 6 . . PUNCT bam-8931 294 1 candidate candidate NOUN bam-8931 294 2 mechanisms mechanism NOUN bam-8931 294 3 underlying underlying ADJ bam-8931 294 4 effects effect NOUN bam-8931 294 5 of of ADP bam-8931 294 6 contractile contractile ADJ bam-8931 294 7 activity activity NOUN bam-8931 294 8 on on ADP bam-8931 294 9 muscle muscle NOUN bam-8931 294 10 morphology morphology NOUN bam-8931 294 11 and and CCONJ bam-8931 294 12 energetics energetic NOUN bam-8931 294 13 in in ADP bam-8931 294 14 cancer cancer NOUN bam-8931 294 15 cachexia cachexia NOUN bam-8931 294 16 . . PUNCT bam-8931 295 1 eur eur PROPN bam-8931 295 2 j j PROPN bam-8931 295 3 cancer cancer NOUN bam-8931 295 4 care care NOUN bam-8931 295 5 ( ( PUNCT bam-8931 295 6 engl engl PROPN bam-8931 295 7 ) ) PUNCT bam-8931 295 8 2012;21:143 2012;21:143 PROPN bam-8931 295 9 - - SYM bam-8931 295 10 57 57 NUM bam-8931 295 11 . . NOUN bam-8931 295 12 39 39 NUM bam-8931 295 13 . . PUNCT bam-8931 296 1 puetz puetz PROPN bam-8931 296 2 tw tw PROPN bam-8931 296 3 , , PUNCT bam-8931 296 4 herring herre VERB bam-8931 296 5 mp mp PROPN bam-8931 296 6 . . PROPN bam-8931 296 7 differential differential ADJ bam-8931 296 8 effects effect NOUN bam-8931 296 9 of of ADP bam-8931 296 10 exercise exercise NOUN bam-8931 296 11 on on ADP bam-8931 296 12 cancer cancer NOUN bam-8931 296 13 - - PUNCT bam-8931 296 14 related relate VERB bam-8931 296 15 fatigue fatigue NOUN bam-8931 296 16 during during ADP bam-8931 296 17 and and CCONJ bam-8931 296 18 following follow VERB bam-8931 296 19 treatment treatment NOUN bam-8931 296 20 : : PUNCT bam-8931 296 21 a a DET bam-8931 296 22 meta meta ADJ bam-8931 296 23 - - PUNCT bam-8931 296 24 analysis analysis NOUN bam-8931 296 25 . . PUNCT bam-8931 297 1 am be AUX bam-8931 297 2 j j PROPN bam-8931 297 3 prev prev X bam-8931 297 4 med med PROPN bam-8931 297 5 2012;43 2012;43 NUM bam-8931 297 6 : : PUNCT bam-8931 297 7 e1 e1 NOUN bam-8931 297 8 - - SYM bam-8931 297 9 24 24 NUM bam-8931 297 10 . . PUNCT bam-8931 297 11 40 40 NUM bam-8931 297 12 . . PUNCT bam-8931 298 1 robergs robergs PROPN bam-8931 298 2 ra ra PROPN bam-8931 298 3 , , PUNCT bam-8931 298 4 ghiasvand ghiasvand NOUN bam-8931 298 5 f f PROPN bam-8931 298 6 , , PUNCT bam-8931 298 7 parker parker PROPN bam-8931 298 8 d. d. PROPN bam-8931 298 9 biochemistry biochemistry PROPN bam-8931 298 10 of of ADP bam-8931 298 11 exercise exercise NOUN bam-8931 298 12 - - PUNCT bam-8931 298 13 induced induce VERB bam-8931 298 14 metabolic metabolic NOUN bam-8931 298 15 acidosis acidosis NOUN bam-8931 298 16 . . PUNCT bam-8931 299 1 am be AUX bam-8931 299 2 j j PROPN bam-8931 299 3 physiol physiol PROPN bam-8931 299 4 regul regul PROPN bam-8931 299 5 integr integr PROPN bam-8931 299 6 comp comp PROPN bam-8931 299 7 physiol physiol PROPN bam-8931 299 8 2004;287 2004;287 NUM bam-8931 299 9 : : PUNCT bam-8931 299 10 r502 r502 NUM bam-8931 299 11 - - SYM bam-8931 299 12 16 16 NUM bam-8931 299 13 . . PUNCT bam-8931 300 1 41 41 NUM bam-8931 300 2 . . PUNCT bam-8931 301 1 constantinou constantinou PROPN bam-8931 301 2 c c PROPN bam-8931 301 3 , , PUNCT bam-8931 301 4 fontes fontes PROPN bam-8931 301 5 de de PROPN bam-8931 301 6 oliveira oliveira PROPN bam-8931 301 7 cc cc PROPN bam-8931 301 8 , , PUNCT bam-8931 301 9 mintzopoulos mintzopoulos PROPN bam-8931 301 10 d d PROPN bam-8931 301 11 , , PUNCT bam-8931 301 12 et et PROPN bam-8931 301 13 al al PROPN bam-8931 301 14 . . PUNCT bam-8931 301 15 nuclear nuclear PROPN bam-8931 301 16 magnetic magnetic ADJ bam-8931 301 17 resonance resonance NOUN bam-8931 301 18 in in ADP bam-8931 301 19 conjunction conjunction NOUN bam-8931 301 20 with with ADP bam-8931 301 21 functional functional ADJ bam-8931 301 22 genomics genomic NOUN bam-8931 301 23 suggests suggest VERB bam-8931 301 24 mitochondrial mitochondrial ADJ bam-8931 301 25 dysfunction dysfunction NOUN bam-8931 301 26 in in ADP bam-8931 301 27 a a DET bam-8931 301 28 murine murine ADJ bam-8931 301 29 model model NOUN bam-8931 301 30 of of ADP bam-8931 301 31 cancer cancer NOUN bam-8931 301 32 cachexia cachexia NOUN bam-8931 301 33 . . PUNCT bam-8931 302 1 int int PROPN bam-8931 302 2 j j PROPN bam-8931 302 3 mol mol ADP bam-8931 302 4 med med PROPN bam-8931 302 5 2011;27:15 2011;27:15 PROPN bam-8931 302 6 - - SYM bam-8931 302 7 24 24 NUM bam-8931 302 8 . . PUNCT bam-8931 303 1 42 42 NUM bam-8931 303 2 . . PUNCT bam-8931 304 1 white white PROPN bam-8931 304 2 jp jp PROPN bam-8931 304 3 , , PUNCT bam-8931 304 4 puppa puppa PROPN bam-8931 304 5 mj mj PROPN bam-8931 304 6 , , PUNCT bam-8931 304 7 sato sato PROPN bam-8931 304 8 s s PART bam-8931 304 9 , , PUNCT bam-8931 304 10 et et PROPN bam-8931 304 11 al al PROPN bam-8931 304 12 . . PROPN bam-8931 304 13 il-6 il-6 NOUN bam-8931 304 14 regulation regulation NOUN bam-8931 304 15 on on ADP bam-8931 304 16 skeletal skeletal ADJ bam-8931 304 17 muscle muscle NOUN bam-8931 304 18 mitochondrial mitochondrial ADJ bam-8931 304 19 remodeling remodeling NOUN bam-8931 304 20 during during ADP bam-8931 304 21 cancer cancer NOUN bam-8931 304 22 cachexia cachexia NOUN bam-8931 304 23 in in ADP bam-8931 304 24 the the DET bam-8931 304 25 apcmin/+ apcmin/+ PROPN bam-8931 304 26 mouse mouse PROPN bam-8931 304 27 . . PUNCT bam-8931 305 1 skelet skelet PROPN bam-8931 305 2 muscle muscle NOUN bam-8931 305 3 2012;2:14 2012;2:14 VERB bam-8931 305 4 . . PUNCT bam-8931 306 1 43 43 NUM bam-8931 306 2 . . PUNCT bam-8931 307 1 murphy murphy PROPN bam-8931 307 2 jl jl PROPN bam-8931 307 3 , , PUNCT bam-8931 307 4 blakely blakely PROPN bam-8931 307 5 el el PROPN bam-8931 307 6 , , PUNCT bam-8931 307 7 schaefer schaefer PROPN bam-8931 307 8 am am PROPN bam-8931 307 9 , , PUNCT bam-8931 307 10 et et PROPN bam-8931 307 11 al al PROPN bam-8931 307 12 . . PROPN bam-8931 308 1 resistance resistance NOUN bam-8931 308 2 training training NOUN bam-8931 308 3 in in ADP bam-8931 308 4 patients patient NOUN bam-8931 308 5 with with ADP bam-8931 308 6 single single ADJ bam-8931 308 7 , , PUNCT bam-8931 308 8 largescale largescale ADJ bam-8931 308 9 deletions deletion NOUN bam-8931 308 10 of of ADP bam-8931 308 11 mitochondrial mitochondrial ADJ bam-8931 308 12 dna dna NOUN bam-8931 308 13 . . PUNCT bam-8931 309 1 brain brain NOUN bam-8931 309 2 2008;131:2832 2008;131:2832 NUM bam-8931 309 3 - - SYM bam-8931 309 4 40 40 NUM bam-8931 309 5 . . PUNCT bam-8931 310 1 muscle muscle NOUN bam-8931 310 2 impairment impairment NOUN bam-8931 310 3 in in ADP bam-8931 310 4 pre pre ADJ bam-8931 310 5 - - ADJ bam-8931 310 6 cachexia cachexia ADJ bam-8931 310 7 cancer cancer NOUN bam-8931 310 8 patients patient NOUN bam-8931 310 9 eur eur PROPN bam-8931 310 10 j j PROPN bam-8931 310 11 transl transl PROPN bam-8931 310 12 myol myol ADV bam-8931 310 13 30 30 NUM bam-8931 310 14 ( ( PUNCT bam-8931 310 15 2 2 NUM bam-8931 310 16 ): ): PUNCT bam-8931 310 17 258 258 NUM bam-8931 310 18 - - SYM bam-8931 310 19 267 267 NUM bam-8931 310 20 , , PUNCT bam-8931 310 21 2020 2020 NUM bam-8931 310 22 267 267 NUM bam-8931 310 23 44 44 NUM bam-8931 310 24 . . PUNCT bam-8931 311 1 dalise dalise PROPN bam-8931 311 2 s s PROPN bam-8931 311 3 , , PUNCT bam-8931 311 4 bertolucci bertolucci PROPN bam-8931 311 5 f f PROPN bam-8931 311 6 , , PUNCT bam-8931 311 7 simonella simonella NOUN bam-8931 311 8 c c NOUN bam-8931 311 9 , , PUNCT bam-8931 311 10 et et PROPN bam-8931 311 11 al al PROPN bam-8931 311 12 . . PROPN bam-8931 312 1 intensive intensive ADJ bam-8931 312 2 aerobic aerobic ADJ bam-8931 312 3 training training NOUN bam-8931 312 4 improves improve VERB bam-8931 312 5 motor motor NOUN bam-8931 312 6 performances performance NOUN bam-8931 312 7 and and CCONJ bam-8931 312 8 oxidative oxidative ADJ bam-8931 312 9 metabolism metabolism NOUN bam-8931 312 10 efficiency efficiency NOUN bam-8931 312 11 in in ADP bam-8931 312 12 chronic chronic ADJ bam-8931 312 13 polymyositis polymyositis NOUN bam-8931 312 14 : : PUNCT bam-8931 312 15 a a DET bam-8931 312 16 case case NOUN bam-8931 312 17 report report NOUN bam-8931 312 18 . . PUNCT bam-8931 313 1 neuromuscul neuromuscul PROPN bam-8931 313 2 disord disord PROPN bam-8931 313 3 2012;22 2012;22 NUM bam-8931 313 4 suppl suppl ADJ bam-8931 313 5 3 3 NUM bam-8931 313 6 : : PUNCT bam-8931 313 7 s221 s221 NUM bam-8931 313 8 - - SYM bam-8931 313 9 5 5 NUM bam-8931 313 10 . . NUM bam-8931 313 11 45 45 NUM bam-8931 313 12 . . PUNCT bam-8931 313 13 yan yan PROPN bam-8931 314 1 z z PROPN bam-8931 314 2 , , PUNCT bam-8931 314 3 lira lira PROPN bam-8931 314 4 va va PROPN bam-8931 314 5 , , PUNCT bam-8931 314 6 greene greene PROPN bam-8931 314 7 np np PROPN bam-8931 314 8 . . PROPN bam-8931 314 9 exercise exercise PROPN bam-8931 314 10 traininginduced traininginduce VERB bam-8931 314 11 regulation regulation NOUN bam-8931 314 12 of of ADP bam-8931 314 13 mitochondrial mitochondrial ADJ bam-8931 314 14 quality quality NOUN bam-8931 314 15 . . PUNCT bam-8931 315 1 exerc exerc PROPN bam-8931 315 2 sport sport PROPN bam-8931 315 3 sci sci PROPN bam-8931 315 4 rev rev VERB bam-8931 315 5 2012;40:159 2012;40:159 PROPN bam-8931 315 6 - - SYM bam-8931 315 7 64 64 NUM bam-8931 315 8 . . PUNCT bam-8931 316 1 46 46 NUM bam-8931 316 2 . . PUNCT bam-8931 317 1 evans evans PROPN bam-8931 317 2 wj wj PROPN bam-8931 317 3 , , PUNCT bam-8931 317 4 roubenoff roubenoff NOUN bam-8931 317 5 r r NOUN bam-8931 317 6 , , PUNCT bam-8931 317 7 shevitz shevitz ADJ bam-8931 317 8 a. a. NOUN bam-8931 317 9 exercise exercise NOUN bam-8931 317 10 and and CCONJ bam-8931 317 11 the the DET bam-8931 317 12 treatment treatment NOUN bam-8931 317 13 of of ADP bam-8931 317 14 wasting waste VERB bam-8931 317 15 : : PUNCT bam-8931 317 16 aging aging NOUN bam-8931 317 17 and and CCONJ bam-8931 317 18 human human ADJ bam-8931 317 19 immunodeficiency immunodeficiency NOUN bam-8931 317 20 virus virus NOUN bam-8931 317 21 infection infection NOUN bam-8931 317 22 . . PUNCT bam-8931 318 1 semin semin PROPN bam-8931 318 2 oncol oncol ADJ bam-8931 319 1 1998;25:112 1998;25:112 NUM bam-8931 319 2 - - SYM bam-8931 319 3 22 22 NUM bam-8931 319 4 . . PUNCT bam-8931 320 1 47 47 NUM bam-8931 320 2 . . PUNCT bam-8931 321 1 hakkinen hakkinen PROPN bam-8931 321 2 a a PROPN bam-8931 321 3 , , PUNCT bam-8931 321 4 pakarinen pakarinen PROPN bam-8931 321 5 a a NOUN bam-8931 321 6 , , PUNCT bam-8931 321 7 hannonen hannonen NOUN bam-8931 321 8 p p NOUN bam-8931 321 9 , , PUNCT bam-8931 321 10 et et PROPN bam-8931 321 11 al al PROPN bam-8931 321 12 . . PUNCT bam-8931 321 13 effects effect NOUN bam-8931 321 14 of of ADP bam-8931 321 15 prolonged prolonged ADJ bam-8931 321 16 combined combine VERB bam-8931 321 17 strength strength NOUN bam-8931 321 18 and and CCONJ bam-8931 321 19 endurance endurance NOUN bam-8931 321 20 training training NOUN bam-8931 321 21 on on ADP bam-8931 321 22 physical physical ADJ bam-8931 321 23 fitness fitness NOUN bam-8931 321 24 , , PUNCT bam-8931 321 25 body body NOUN bam-8931 321 26 composition composition NOUN bam-8931 321 27 and and CCONJ bam-8931 321 28 serum serum NOUN bam-8931 321 29 hormones hormone NOUN bam-8931 321 30 in in ADP bam-8931 321 31 women woman NOUN bam-8931 321 32 with with ADP bam-8931 321 33 rheumatoid rheumatoid NOUN bam-8931 321 34 arthritis arthritis NOUN bam-8931 321 35 and and CCONJ bam-8931 321 36 in in ADP bam-8931 321 37 healthy healthy ADJ bam-8931 321 38 controls control NOUN bam-8931 321 39 . . PUNCT bam-8931 322 1 clin clin PROPN bam-8931 322 2 exp exp NOUN bam-8931 322 3 rheumatol rheumatol NOUN bam-8931 322 4 2005;23:505 2005;23:505 NUM bam-8931 322 5 - - SYM bam-8931 322 6 12 12 NUM bam-8931 322 7 . . PUNCT bam-8931 323 1 submitted submit VERB bam-8931 323 2 : : PUNCT bam-8931 323 3 february february PROPN bam-8931 323 4 , , PUNCT bam-8931 323 5 28 28 NUM bam-8931 323 6 , , PUNCT bam-8931 323 7 2019 2019 NUM bam-8931 323 8 revision revision NOUN bam-8931 323 9 received receive VERB bam-8931 323 10 : : PUNCT bam-8931 323 11 march march PROPN bam-8931 323 12 28 28 NUM bam-8931 323 13 , , PUNCT bam-8931 323 14 2020 2020 NUM bam-8931 323 15 accepted accept VERB bam-8931 323 16 for for ADP bam-8931 323 17 publication publication NOUN bam-8931 323 18 : : PUNCT bam-8931 323 19 march march PROPN bam-8931 323 20 28 28 NUM bam-8931 323 21 , , PUNCT bam-8931 323 22 2020 2020 NUM