id	sid	tid	token	lemma	pos
bam-9610	1	1	evaluation	evaluation	NOUN
bam-9610	1	2	of	of	ADP
bam-9610	1	3	orphan	orphan	NOUN
bam-9610	1	4	diseases	disease	NOUN
bam-9610	1	5	global	global	ADJ
bam-9610	1	6	burden	burden	PROPN
bam-9610	1	7	eur	eur	PROPN
bam-9610	1	8	j	j	PROPN
bam-9610	1	9	transl	transl	PROPN
bam-9610	1	10	myol	myol	NOUN
bam-9610	1	11	2021	2021	NUM
bam-9610	1	12	;	;	PUNCT
bam-9610	1	13	31	31	NUM
bam-9610	1	14	(	(	PUNCT
bam-9610	1	15	2	2	NUM
bam-9610	1	16	):	):	PUNCT
bam-9610	1	17	9610	9610	NUM
bam-9610	1	18	.	.	PUNCT
bam-9610	2	1	doi	doi	NOUN
bam-9610	2	2	:	:	PUNCT
bam-9610	2	3	10.4081	10.4081	NUM
bam-9610	2	4	/	/	SYM
bam-9610	2	5	ejtm.2021.9610	ejtm.2021.9610	VERB
bam-9610	2	6	1	1	NUM
bam-9610	2	7	evaluation	evaluation	NOUN
bam-9610	2	8	of	of	ADP
bam-9610	2	9	orphan	orphan	NOUN
bam-9610	2	10	diseases	disease	NOUN
bam-9610	2	11	global	global	ADJ
bam-9610	2	12	burden	burden	PROPN
bam-9610	2	13	ekaterina	ekaterina	PROPN
bam-9610	2	14	v	v	ADP
bam-9610	2	15	makarova	makarova	PROPN
bam-9610	2	16	(	(	PUNCT
bam-9610	2	17	1	1	NUM
bam-9610	2	18	)	)	PUNCT
bam-9610	2	19	,	,	PUNCT
bam-9610	2	20	ivan	ivan	PROPN
bam-9610	2	21	s	s	PROPN
bam-9610	2	22	krysanov	krysanov	PROPN
bam-9610	2	23	(	(	PUNCT
bam-9610	2	24	1	1	NUM
bam-9610	2	25	)	)	PUNCT
bam-9610	2	26	,	,	PUNCT
bam-9610	2	27	tatiana	tatiana	PROPN
bam-9610	2	28	p	p	PROPN
bam-9610	2	29	vasilyeva	vasilyeva	PROPN
bam-9610	2	30	(	(	PUNCT
bam-9610	2	31	1	1	NUM
bam-9610	2	32	)	)	PUNCT
bam-9610	2	33	,	,	PUNCT
bam-9610	2	34	mikhail	mikhail	PROPN
bam-9610	2	35	d	d	X
bam-9610	2	36	vasiliev	vasiliev	NOUN
bam-9610	2	37	(	(	PUNCT
bam-9610	2	38	1	1	NUM
bam-9610	2	39	)	)	PUNCT
bam-9610	2	40	,	,	PUNCT
bam-9610	2	41	rena	rena	PROPN
bam-9610	2	42	a	a	DET
bam-9610	2	43	zinchenko	zinchenko	ADJ
bam-9610	2	44	(	(	PUNCT
bam-9610	2	45	2	2	NUM
bam-9610	2	46	)	)	PUNCT
bam-9610	2	47	(	(	PUNCT
bam-9610	2	48	1	1	X
bam-9610	2	49	)	)	PUNCT
bam-9610	2	50	national	national	PROPN
bam-9610	2	51	research	research	PROPN
bam-9610	2	52	institute	institute	PROPN
bam-9610	2	53	of	of	ADP
bam-9610	2	54	public	public	ADJ
bam-9610	2	55	health	health	PROPN
bam-9610	2	56	n.a	n.a	PROPN
bam-9610	2	57	.	.	PROPN
bam-9610	2	58	n.а	n.а	PROPN
bam-9610	2	59	.	.	PROPN
bam-9610	2	60	semashko	semashko	PROPN
bam-9610	2	61	,	,	PUNCT
bam-9610	2	62	moscow	moscow	PROPN
bam-9610	2	63	,	,	PUNCT
bam-9610	2	64	russia	russia	PROPN
bam-9610	2	65	;	;	PUNCT
bam-9610	2	66	(	(	PUNCT
bam-9610	2	67	2	2	X
bam-9610	2	68	)	)	PUNCT
bam-9610	2	69	research	research	NOUN
bam-9610	2	70	centre	centre	NOUN
bam-9610	2	71	for	for	ADP
bam-9610	2	72	medical	medical	ADJ
bam-9610	2	73	genetics	genetic	NOUN
bam-9610	2	74	n.a	n.a	PROPN
bam-9610	2	75	.	.	PROPN
bam-9610	2	76	acad	acad	PROPN
bam-9610	2	77	.	.	PUNCT
bam-9610	3	1	n.p	n.p	PROPN
bam-9610	3	2	.	.	PROPN
bam-9610	3	3	bochkov	bochkov	PROPN
bam-9610	3	4	,	,	PUNCT
bam-9610	3	5	moscow	moscow	PROPN
bam-9610	3	6	,	,	PUNCT
bam-9610	3	7	russia	russia	PROPN
bam-9610	3	8	.	.	PUNCT
bam-9610	4	1	this	this	DET
bam-9610	4	2	article	article	NOUN
bam-9610	4	3	is	be	AUX
bam-9610	4	4	distributed	distribute	VERB
bam-9610	4	5	under	under	ADP
bam-9610	4	6	the	the	DET
bam-9610	4	7	terms	term	NOUN
bam-9610	4	8	of	of	ADP
bam-9610	4	9	the	the	DET
bam-9610	4	10	creative	creative	ADJ
bam-9610	4	11	commons	common	NOUN
bam-9610	4	12	attribution	attribution	NOUN
bam-9610	4	13	noncommercial	noncommercial	ADJ
bam-9610	4	14	license	license	NOUN
bam-9610	4	15	(	(	PUNCT
bam-9610	4	16	cc	cc	NOUN
bam-9610	4	17	by	by	ADP
bam-9610	4	18	-	-	PUNCT
bam-9610	4	19	nc	nc	PROPN
bam-9610	4	20	4.0	4.0	NUM
bam-9610	4	21	)	)	PUNCT
bam-9610	4	22	which	which	PRON
bam-9610	4	23	permits	permit	VERB
bam-9610	4	24	any	any	DET
bam-9610	4	25	noncommercial	noncommercial	ADJ
bam-9610	4	26	use	use	NOUN
bam-9610	4	27	,	,	PUNCT
bam-9610	4	28	distribution	distribution	NOUN
bam-9610	4	29	,	,	PUNCT
bam-9610	4	30	and	and	CCONJ
bam-9610	4	31	reproduction	reproduction	NOUN
bam-9610	4	32	in	in	ADP
bam-9610	4	33	any	any	DET
bam-9610	4	34	medium	medium	NOUN
bam-9610	4	35	,	,	PUNCT
bam-9610	4	36	provided	provide	VERB
bam-9610	4	37	the	the	DET
bam-9610	4	38	original	original	ADJ
bam-9610	4	39	author(s	author(s	NOUN
bam-9610	4	40	)	)	PUNCT
bam-9610	4	41	and	and	CCONJ
bam-9610	4	42	source	source	NOUN
bam-9610	4	43	are	be	AUX
bam-9610	4	44	credited	credit	VERB
bam-9610	4	45	.	.	PUNCT
bam-9610	5	1	abstract	abstract	ADJ
bam-9610	5	2	orphan	orphan	NOUN
bam-9610	5	3	diseases	disease	NOUN
bam-9610	5	4	is	be	AUX
bam-9610	5	5	a	a	DET
bam-9610	5	6	significant	significant	ADJ
bam-9610	5	7	socio	socio	NOUN
bam-9610	5	8	-	-	PUNCT
bam-9610	5	9	economic	economic	ADJ
bam-9610	5	10	burden	burden	NOUN
bam-9610	5	11	for	for	ADP
bam-9610	5	12	both	both	CCONJ
bam-9610	5	13	global	global	ADJ
bam-9610	5	14	and	and	CCONJ
bam-9610	5	15	russian	russian	ADJ
bam-9610	5	16	health	health	NOUN
bam-9610	5	17	care	care	NOUN
bam-9610	5	18	systems	system	NOUN
bam-9610	5	19	.	.	PUNCT
bam-9610	6	1	the	the	DET
bam-9610	6	2	global	global	ADJ
bam-9610	6	3	burden	burden	NOUN
bam-9610	6	4	of	of	ADP
bam-9610	6	5	disease	disease	NOUN
bam-9610	6	6	metrics	metric	NOUN
bam-9610	6	7	introduced	introduce	VERB
bam-9610	6	8	by	by	ADP
bam-9610	6	9	who	who	PRON
bam-9610	6	10	,	,	PUNCT
bam-9610	6	11	such	such	ADJ
bam-9610	6	12	as	as	ADP
bam-9610	6	13	daly	daly	PROPN
bam-9610	6	14	,	,	PUNCT
bam-9610	6	15	qaly	qaly	PROPN
bam-9610	6	16	,	,	PUNCT
bam-9610	6	17	hale	hale	PROPN
bam-9610	6	18	,	,	PUNCT
bam-9610	6	19	can	can	AUX
bam-9610	6	20	be	be	AUX
bam-9610	6	21	a	a	DET
bam-9610	6	22	useful	useful	ADJ
bam-9610	6	23	tool	tool	NOUN
bam-9610	6	24	for	for	ADP
bam-9610	6	25	building	build	VERB
bam-9610	6	26	economic	economic	ADJ
bam-9610	6	27	models	model	NOUN
bam-9610	6	28	and	and	CCONJ
bam-9610	6	29	prognoses	prognosis	NOUN
bam-9610	6	30	,	,	PUNCT
bam-9610	6	31	as	as	ADV
bam-9610	6	32	well	well	ADV
bam-9610	6	33	as	as	ADP
bam-9610	6	34	medicine	medicine	NOUN
bam-9610	6	35	funding	funding	NOUN
bam-9610	6	36	distribution	distribution	NOUN
bam-9610	6	37	.	.	PUNCT
bam-9610	7	1	however	however	ADV
bam-9610	7	2	,	,	PUNCT
bam-9610	7	3	it	it	PRON
bam-9610	7	4	is	be	AUX
bam-9610	7	5	very	very	ADV
bam-9610	7	6	difficult	difficult	ADJ
bam-9610	7	7	to	to	PART
bam-9610	7	8	standardize	standardize	VERB
bam-9610	7	9	a	a	DET
bam-9610	7	10	heterogeneous	heterogeneous	ADJ
bam-9610	7	11	group	group	NOUN
bam-9610	7	12	of	of	ADP
bam-9610	7	13	rare	rare	ADJ
bam-9610	7	14	diseases	disease	NOUN
bam-9610	7	15	and	and	CCONJ
bam-9610	7	16	it	it	PRON
bam-9610	7	17	is	be	AUX
bam-9610	7	18	difficult	difficult	ADJ
bam-9610	7	19	to	to	PART
bam-9610	7	20	talk	talk	VERB
bam-9610	7	21	about	about	ADP
bam-9610	7	22	the	the	DET
bam-9610	7	23	cost	cost	NOUN
bam-9610	7	24	-	-	PUNCT
bam-9610	7	25	effective	effective	ADJ
bam-9610	7	26	treatment	treatment	NOUN
bam-9610	7	27	options	option	NOUN
bam-9610	7	28	search	search	NOUN
bam-9610	7	29	,	,	PUNCT
bam-9610	7	30	in	in	ADP
bam-9610	7	31	cases	case	NOUN
bam-9610	7	32	where	where	SCONJ
bam-9610	7	33	patients	patient	NOUN
bam-9610	7	34	with	with	ADP
bam-9610	7	35	an	an	DET
bam-9610	7	36	orphan	orphan	NOUN
bam-9610	7	37	disease	disease	NOUN
bam-9610	7	38	may	may	AUX
bam-9610	7	39	have	have	VERB
bam-9610	7	40	only	only	ADV
bam-9610	7	41	one	one	NUM
bam-9610	7	42	pathogenetic	pathogenetic	ADJ
bam-9610	7	43	therapy	therapy	NOUN
bam-9610	7	44	option	option	NOUN
bam-9610	7	45	.	.	PUNCT
bam-9610	8	1	much	much	ADJ
bam-9610	8	2	work	work	NOUN
bam-9610	8	3	needs	need	VERB
bam-9610	8	4	to	to	PART
bam-9610	8	5	be	be	AUX
bam-9610	8	6	done	do	VERB
bam-9610	8	7	to	to	PART
bam-9610	8	8	find	find	VERB
bam-9610	8	9	optimal	optimal	ADJ
bam-9610	8	10	treatment	treatment	NOUN
bam-9610	8	11	options	option	NOUN
bam-9610	8	12	and	and	CCONJ
bam-9610	8	13	establish	establish	VERB
bam-9610	8	14	the	the	DET
bam-9610	8	15	standards	standard	NOUN
bam-9610	8	16	of	of	ADP
bam-9610	8	17	care	care	NOUN
bam-9610	8	18	necessary	necessary	ADJ
bam-9610	8	19	to	to	PART
bam-9610	8	20	maintain	maintain	VERB
bam-9610	8	21	physical	physical	ADJ
bam-9610	8	22	health	health	NOUN
bam-9610	8	23	,	,	PUNCT
bam-9610	8	24	work	work	NOUN
bam-9610	8	25	capacity	capacity	NOUN
bam-9610	8	26	and	and	CCONJ
bam-9610	8	27	quality	quality	NOUN
bam-9610	8	28	of	of	ADP
bam-9610	8	29	life	life	NOUN
bam-9610	8	30	.	.	PUNCT
bam-9610	9	1	key	key	ADJ
bam-9610	9	2	words	word	NOUN
bam-9610	9	3	:	:	PUNCT
bam-9610	9	4	orphan	orphan	NOUN
bam-9610	9	5	diseases	disease	NOUN
bam-9610	9	6	;	;	PUNCT
bam-9610	9	7	rare	rare	ADJ
bam-9610	9	8	diseases	disease	NOUN
bam-9610	9	9	;	;	PUNCT
bam-9610	9	10	global	global	ADJ
bam-9610	9	11	disease	disease	NOUN
bam-9610	9	12	time	time	NOUN
bam-9610	9	13	;	;	PUNCT
bam-9610	9	14	disability	disability	NOUN
bam-9610	9	15	;	;	PUNCT
bam-9610	9	16	quality	quality	NOUN
bam-9610	9	17	of	of	ADP
bam-9610	9	18	life	life	NOUN
bam-9610	9	19	;	;	PUNCT
bam-9610	9	20	daly	daly	PROPN
bam-9610	9	21	;	;	PUNCT
bam-9610	9	22	qaly	qaly	PROPN
bam-9610	9	23	;	;	PUNCT
bam-9610	9	24	hale	hale	PROPN
bam-9610	9	25	.	.	PUNCT
bam-9610	10	1	eur	eur	PROPN
bam-9610	10	2	j	j	PROPN
bam-9610	10	3	transl	transl	PROPN
bam-9610	10	4	myol	myol	NOUN
bam-9610	10	5	2020	2020	NUM
bam-9610	10	6	;	;	PUNCT
bam-9610	10	7	31	31	NUM
bam-9610	10	8	(	(	PUNCT
bam-9610	10	9	2	2	NUM
bam-9610	10	10	):	):	PUNCT
bam-9610	10	11	9610	9610	NUM
bam-9610	10	12	.	.	PUNCT
bam-9610	11	1	doi	doi	NOUN
bam-9610	11	2	:	:	PUNCT
bam-9610	11	3	10.4081	10.4081	NUM
bam-9610	11	4	/	/	SYM
bam-9610	11	5	ejtm.2021.9610	ejtm.2021.9610	VERB
bam-9610	11	6	modern	modern	ADJ
bam-9610	11	7	world	world	NOUN
bam-9610	11	8	is	be	AUX
bam-9610	11	9	changing	change	VERB
bam-9610	11	10	rapidly	rapidly	ADV
bam-9610	11	11	and	and	CCONJ
bam-9610	11	12	dynamically	dynamically	ADV
bam-9610	11	13	whit	whit	NOUN
bam-9610	11	14	increasing	increase	VERB
bam-9610	11	15	population	population	NOUN
bam-9610	11	16	and	and	CCONJ
bam-9610	11	17	duration	duration	NOUN
bam-9610	11	18	of	of	ADP
bam-9610	11	19	life	life	NOUN
bam-9610	11	20	.	.	PUNCT
bam-9610	12	1	in	in	ADP
bam-9610	12	2	these	these	DET
bam-9610	12	3	conditions	condition	NOUN
bam-9610	12	4	,	,	PUNCT
bam-9610	12	5	maintenance	maintenance	NOUN
bam-9610	12	6	of	of	ADP
bam-9610	12	7	a	a	DET
bam-9610	12	8	person	person	NOUN
bam-9610	12	9	's	's	PART
bam-9610	12	10	legal	legal	ADJ
bam-9610	12	11	capacity	capacity	NOUN
bam-9610	12	12	and	and	CCONJ
bam-9610	12	13	quality	quality	NOUN
bam-9610	12	14	of	of	ADP
bam-9610	12	15	life	life	NOUN
bam-9610	12	16	is	be	AUX
bam-9610	12	17	of	of	ADP
bam-9610	12	18	particular	particular	ADJ
bam-9610	12	19	importance	importance	NOUN
bam-9610	12	20	.	.	PUNCT
bam-9610	13	1	thanks	thank	NOUN
bam-9610	13	2	to	to	ADP
bam-9610	13	3	modern	modern	ADJ
bam-9610	13	4	advances	advance	NOUN
bam-9610	13	5	in	in	ADP
bam-9610	13	6	medical	medical	ADJ
bam-9610	13	7	science	science	NOUN
bam-9610	13	8	,	,	PUNCT
bam-9610	13	9	it	it	PRON
bam-9610	13	10	has	have	AUX
bam-9610	13	11	become	become	VERB
bam-9610	13	12	possible	possible	ADJ
bam-9610	13	13	to	to	PART
bam-9610	13	14	reduce	reduce	VERB
bam-9610	13	15	mortality	mortality	NOUN
bam-9610	13	16	and	and	CCONJ
bam-9610	13	17	to	to	PART
bam-9610	13	18	treat	treat	VERB
bam-9610	13	19	or	or	CCONJ
bam-9610	13	20	compensate	compensate	VERB
bam-9610	13	21	for	for	ADP
bam-9610	13	22	diseases	disease	NOUN
bam-9610	13	23	previously	previously	ADV
bam-9610	13	24	considered	consider	VERB
bam-9610	13	25	incurable	incurable	ADJ
bam-9610	13	26	.	.	PUNCT
bam-9610	14	1	these	these	DET
bam-9610	14	2	undoubtedly	undoubtedly	ADV
bam-9610	14	3	positive	positive	ADJ
bam-9610	14	4	changes	change	NOUN
bam-9610	14	5	,	,	PUNCT
bam-9610	14	6	nevertheless	nevertheless	ADV
bam-9610	14	7	,	,	PUNCT
bam-9610	14	8	are	be	AUX
bam-9610	14	9	associated	associate	VERB
bam-9610	14	10	with	with	ADP
bam-9610	14	11	increasing	increase	VERB
bam-9610	14	12	number	number	NOUN
bam-9610	14	13	of	of	ADP
bam-9610	14	14	patients	patient	NOUN
bam-9610	14	15	with	with	ADP
bam-9610	14	16	functional	functional	ADJ
bam-9610	14	17	limitations	limitation	NOUN
bam-9610	14	18	,	,	PUNCT
bam-9610	14	19	of	of	ADP
bam-9610	14	20	burden	burden	NOUN
bam-9610	14	21	on	on	ADP
bam-9610	14	22	health	health	NOUN
bam-9610	14	23	care	care	NOUN
bam-9610	14	24	and	and	CCONJ
bam-9610	14	25	difficulties	difficulty	NOUN
bam-9610	14	26	in	in	ADP
bam-9610	14	27	budget	budget	NOUN
bam-9610	14	28	planning	planning	NOUN
bam-9610	14	29	.	.	PUNCT
bam-9610	15	1	country	country	NOUN
bam-9610	15	2	leaders	leader	NOUN
bam-9610	15	3	,	,	PUNCT
bam-9610	15	4	ministries	ministry	NOUN
bam-9610	15	5	and	and	CCONJ
bam-9610	15	6	public	public	ADJ
bam-9610	15	7	organizations	organization	NOUN
bam-9610	15	8	have	have	VERB
bam-9610	15	9	a	a	DET
bam-9610	15	10	serious	serious	ADJ
bam-9610	15	11	interest	interest	NOUN
bam-9610	15	12	in	in	ADP
bam-9610	15	13	maintaining	maintain	VERB
bam-9610	15	14	health	health	NOUN
bam-9610	15	15	of	of	ADP
bam-9610	15	16	citizens	citizen	NOUN
bam-9610	15	17	and	and	CCONJ
bam-9610	15	18	their	their	PRON
bam-9610	15	19	ability	ability	NOUN
bam-9610	15	20	to	to	PART
bam-9610	15	21	work	work	VERB
bam-9610	15	22	,	,	PUNCT
bam-9610	15	23	both	both	CCONJ
bam-9610	15	24	for	for	ADP
bam-9610	15	25	ethical	ethical	ADJ
bam-9610	15	26	and	and	CCONJ
bam-9610	15	27	financial	financial	ADJ
bam-9610	15	28	reasons	reason	NOUN
bam-9610	15	29	.	.	PUNCT
bam-9610	16	1	that	that	PRON
bam-9610	16	2	is	be	AUX
bam-9610	16	3	why	why	SCONJ
bam-9610	16	4	today	today	NOUN
bam-9610	16	5	socio	socio	NOUN
bam-9610	16	6	-	-	ADJ
bam-9610	16	7	demographic	demographic	ADJ
bam-9610	16	8	characteristics	characteristic	NOUN
bam-9610	16	9	are	be	AUX
bam-9610	16	10	carefully	carefully	ADV
bam-9610	16	11	studied	study	VERB
bam-9610	16	12	and	and	CCONJ
bam-9610	16	13	analyzed	analyze	VERB
bam-9610	16	14	,	,	PUNCT
bam-9610	16	15	which	which	PRON
bam-9610	16	16	make	make	VERB
bam-9610	16	17	it	it	PRON
bam-9610	16	18	possible	possible	ADJ
bam-9610	16	19	to	to	PART
bam-9610	16	20	form	form	VERB
bam-9610	16	21	impression	impression	NOUN
bam-9610	16	22	of	of	ADP
bam-9610	16	23	the	the	DET
bam-9610	16	24	health	health	NOUN
bam-9610	16	25	of	of	ADP
bam-9610	16	26	the	the	DET
bam-9610	16	27	population	population	NOUN
bam-9610	16	28	,	,	PUNCT
bam-9610	16	29	to	to	PART
bam-9610	16	30	assess	assess	VERB
bam-9610	16	31	contribution	contribution	NOUN
bam-9610	16	32	of	of	ADP
bam-9610	16	33	individual	individual	ADJ
bam-9610	16	34	diseases	disease	NOUN
bam-9610	16	35	to	to	ADP
bam-9610	16	36	permanent	permanent	ADJ
bam-9610	16	37	and	and	CCONJ
bam-9610	16	38	temporary	temporary	ADJ
bam-9610	16	39	disability	disability	NOUN
bam-9610	16	40	,	,	PUNCT
bam-9610	16	41	the	the	DET
bam-9610	16	42	so	so	ADV
bam-9610	16	43	-	-	PUNCT
bam-9610	16	44	called	call	VERB
bam-9610	16	45	global	global	ADJ
bam-9610	16	46	burden	burden	NOUN
bam-9610	16	47	of	of	ADP
bam-9610	16	48	disease	disease	NOUN
bam-9610	16	49	(	(	PUNCT
bam-9610	16	50	gbd	gbd	NOUN
bam-9610	16	51	)	)	PUNCT
bam-9610	16	52	.	.	PUNCT
bam-9610	17	1	gbd	gbd	PROPN
bam-9610	17	2	–	–	PUNCT
bam-9610	17	3	is	be	AUX
bam-9610	17	4	the	the	DET
bam-9610	17	5	basis	basis	NOUN
bam-9610	17	6	for	for	ADP
bam-9610	17	7	compiling	compile	VERB
bam-9610	17	8	economic	economic	ADJ
bam-9610	17	9	models	model	NOUN
bam-9610	17	10	,	,	PUNCT
bam-9610	17	11	forecasting	forecast	VERB
bam-9610	17	12	spending	spending	NOUN
bam-9610	17	13	and	and	CCONJ
bam-9610	17	14	distributing	distribute	VERB
bam-9610	17	15	financial	financial	ADJ
bam-9610	17	16	resources	resource	NOUN
bam-9610	17	17	in	in	ADP
bam-9610	17	18	health	health	NOUN
bam-9610	17	19	care.1	care.1	PROPN
bam-9610	17	20	unfortunately	unfortunately	ADV
bam-9610	17	21	,	,	PUNCT
bam-9610	17	22	information	information	NOUN
bam-9610	17	23	on	on	ADP
bam-9610	17	24	mortality	mortality	NOUN
bam-9610	17	25	and	and	CCONJ
bam-9610	17	26	health	health	NOUN
bam-9610	17	27	of	of	ADP
bam-9610	17	28	the	the	DET
bam-9610	17	29	population	population	NOUN
bam-9610	17	30	in	in	ADP
bam-9610	17	31	all	all	DET
bam-9610	17	32	regions	region	NOUN
bam-9610	17	33	of	of	ADP
bam-9610	17	34	the	the	DET
bam-9610	17	35	world	world	NOUN
bam-9610	17	36	is	be	AUX
bam-9610	17	37	very	very	ADV
bam-9610	17	38	fragmentary	fragmentary	ADJ
bam-9610	17	39	and	and	CCONJ
bam-9610	17	40	quite	quite	ADV
bam-9610	17	41	contradictory	contradictory	ADJ
bam-9610	17	42	.	.	PUNCT
bam-9610	18	1	this	this	DET
bam-9610	18	2	highlights	highlight	NOUN
bam-9610	18	3	the	the	DET
bam-9610	18	4	need	need	NOUN
bam-9610	18	5	to	to	PART
bam-9610	18	6	use	use	VERB
bam-9610	18	7	common	common	ADJ
bam-9610	18	8	terms	term	NOUN
bam-9610	18	9	,	,	PUNCT
bam-9610	18	10	metrics	metric	NOUN
bam-9610	18	11	and	and	CCONJ
bam-9610	18	12	criteria	criterion	NOUN
bam-9610	18	13	to	to	PART
bam-9610	18	14	describe	describe	VERB
bam-9610	18	15	and	and	CCONJ
bam-9610	18	16	analyze	analyze	VERB
bam-9610	18	17	public	public	ADJ
bam-9610	18	18	health	health	NOUN
bam-9610	18	19	problems	problem	NOUN
bam-9610	18	20	and	and	CCONJ
bam-9610	18	21	burden	burden	NOUN
bam-9610	18	22	of	of	ADP
bam-9610	18	23	different	different	ADJ
bam-9610	18	24	diseases	disease	NOUN
bam-9610	18	25	,	,	PUNCT
bam-9610	18	26	injuries	injury	NOUN
bam-9610	18	27	and	and	CCONJ
bam-9610	18	28	risk	risk	NOUN
bam-9610	18	29	factors	factor	NOUN
bam-9610	18	30	.	.	PUNCT
bam-9610	19	1	introduction	introduction	NOUN
bam-9610	19	2	of	of	ADP
bam-9610	19	3	common	common	ADJ
bam-9610	19	4	framework	framework	NOUN
bam-9610	19	5	for	for	ADP
bam-9610	19	6	collecting	collecting	NOUN
bam-9610	19	7	,	,	PUNCT
bam-9610	19	8	integrating	integrating	NOUN
bam-9610	19	9	,	,	PUNCT
bam-9610	19	10	validating	validate	VERB
bam-9610	19	11	,	,	PUNCT
bam-9610	19	12	analyzing	analyzing	NOUN
bam-9610	19	13	,	,	PUNCT
bam-9610	19	14	and	and	CCONJ
bam-9610	19	15	benchmarking	benchmarke	VERB
bam-9610	19	16	data	datum	NOUN
bam-9610	19	17	would	would	AUX
bam-9610	19	18	be	be	AUX
bam-9610	19	19	of	of	ADP
bam-9610	19	20	great	great	ADJ
bam-9610	19	21	benefit	benefit	NOUN
bam-9610	19	22	.	.	PUNCT
bam-9610	20	1	availability	availability	NOUN
bam-9610	20	2	of	of	ADP
bam-9610	20	3	objective	objective	ADJ
bam-9610	20	4	and	and	CCONJ
bam-9610	20	5	comprehensive	comprehensive	ADJ
bam-9610	20	6	data	datum	NOUN
bam-9610	20	7	on	on	ADP
bam-9610	20	8	socially	socially	ADV
bam-9610	20	9	significant	significant	ADJ
bam-9610	20	10	gbd	gbd	NOUN
bam-9610	20	11	indicators	indicator	NOUN
bam-9610	20	12	would	would	AUX
bam-9610	20	13	give	give	VERB
bam-9610	20	14	the	the	DET
bam-9610	20	15	authorities	authority	NOUN
bam-9610	20	16	not	not	PART
bam-9610	20	17	only	only	ADV
bam-9610	20	18	the	the	DET
bam-9610	20	19	opportunity	opportunity	NOUN
bam-9610	20	20	to	to	PART
bam-9610	20	21	comprehensively	comprehensively	ADV
bam-9610	20	22	consider	consider	VERB
bam-9610	20	23	the	the	DET
bam-9610	20	24	current	current	ADJ
bam-9610	20	25	picture	picture	NOUN
bam-9610	20	26	and	and	CCONJ
bam-9610	20	27	emerging	emerge	VERB
bam-9610	20	28	trends	trend	NOUN
bam-9610	20	29	in	in	ADP
bam-9610	20	30	the	the	DET
bam-9610	20	31	health	health	NOUN
bam-9610	20	32	status	status	NOUN
bam-9610	20	33	of	of	ADP
bam-9610	20	34	the	the	DET
bam-9610	20	35	population	population	NOUN
bam-9610	20	36	,	,	PUNCT
bam-9610	20	37	but	but	CCONJ
bam-9610	20	38	to	to	PART
bam-9610	20	39	implement	implement	VERB
bam-9610	20	40	effective	effective	ADJ
bam-9610	20	41	programs	program	NOUN
bam-9610	20	42	to	to	PART
bam-9610	20	43	preserve	preserve	VERB
bam-9610	20	44	health	health	NOUN
bam-9610	20	45	and	and	CCONJ
bam-9610	20	46	to	to	PART
bam-9610	20	47	eliminate	eliminate	VERB
bam-9610	20	48	identified	identify	VERB
bam-9610	20	49	problems	problem	NOUN
bam-9610	20	50	.	.	PUNCT
bam-9610	21	1	orphan	orphan	NOUN
bam-9610	21	2	diseases	disease	NOUN
bam-9610	21	3	orphan	orphan	NOUN
bam-9610	21	4	diseases	disease	NOUN
bam-9610	21	5	are	be	AUX
bam-9610	21	6	an	an	DET
bam-9610	21	7	important	important	ADJ
bam-9610	21	8	problem	problem	NOUN
bam-9610	21	9	of	of	ADP
bam-9610	21	10	modern	modern	ADJ
bam-9610	21	11	healthcare	healthcare	NOUN
bam-9610	21	12	that	that	PRON
bam-9610	21	13	requires	require	VERB
bam-9610	21	14	a	a	DET
bam-9610	21	15	special	special	ADJ
bam-9610	21	16	approach	approach	NOUN
bam-9610	21	17	and	and	CCONJ
bam-9610	21	18	careful	careful	ADJ
bam-9610	21	19	budget	budget	NOUN
bam-9610	21	20	planning	planning	NOUN
bam-9610	21	21	.	.	PUNCT
bam-9610	22	1	"	"	PUNCT
bam-9610	22	2	orphan	orphan	NOUN
bam-9610	22	3	"	"	PUNCT
bam-9610	22	4	,	,	PUNCT
bam-9610	22	5	or	or	CCONJ
bam-9610	22	6	rare	rare	ADJ
bam-9610	22	7	diseases	disease	NOUN
bam-9610	22	8	,	,	PUNCT
bam-9610	22	9	is	be	AUX
bam-9610	22	10	an	an	DET
bam-9610	22	11	umbrella	umbrella	NOUN
bam-9610	22	12	term	term	NOUN
bam-9610	22	13	for	for	ADP
bam-9610	22	14	a	a	DET
bam-9610	22	15	group	group	NOUN
bam-9610	22	16	of	of	ADP
bam-9610	22	17	nosologies	nosology	NOUN
bam-9610	22	18	that	that	PRON
bam-9610	22	19	are	be	AUX
bam-9610	22	20	less	less	ADV
bam-9610	22	21	common	common	ADJ
bam-9610	22	22	than	than	ADP
bam-9610	22	23	the	the	DET
bam-9610	22	24	frequency	frequency	NOUN
bam-9610	22	25	established	establish	VERB
bam-9610	22	26	by	by	ADP
bam-9610	22	27	the	the	DET
bam-9610	22	28	legislation	legislation	NOUN
bam-9610	22	29	of	of	ADP
bam-9610	22	30	each	each	DET
bam-9610	22	31	country.2,3	country.2,3	ADJ
bam-9610	22	32	there	there	PRON
bam-9610	22	33	is	be	VERB
bam-9610	22	34	no	no	DET
bam-9610	22	35	standard	standard	ADJ
bam-9610	22	36	definition	definition	NOUN
bam-9610	22	37	of	of	ADP
bam-9610	22	38	a	a	DET
bam-9610	22	39	rare	rare	ADJ
bam-9610	22	40	disease	disease	NOUN
bam-9610	22	41	;	;	PUNCT
bam-9610	22	42	on	on	ADP
bam-9610	22	43	average	average	ADJ
bam-9610	22	44	,	,	PUNCT
bam-9610	22	45	a	a	DET
bam-9610	22	46	disease	disease	NOUN
bam-9610	22	47	is	be	AUX
bam-9610	22	48	considered	consider	VERB
bam-9610	22	49	rare	rare	ADJ
bam-9610	22	50	if	if	SCONJ
bam-9610	22	51	it	it	PRON
bam-9610	22	52	affects	affect	VERB
bam-9610	22	53	fewer	few	ADJ
bam-9610	22	54	than	than	ADP
bam-9610	22	55	7	7	NUM
bam-9610	22	56	out	out	ADP
bam-9610	22	57	of	of	ADP
bam-9610	22	58	10.000	10.000	NUM
bam-9610	22	59	people	people	NOUN
bam-9610	22	60	in	in	ADP
bam-9610	22	61	the	the	DET
bam-9610	22	62	population	population	NOUN
bam-9610	22	63	.	.	PUNCT
bam-9610	23	1	according	accord	VERB
bam-9610	23	2	to	to	ADP
bam-9610	23	3	the	the	DET
bam-9610	23	4	existing	exist	VERB
bam-9610	23	5	requirements	requirement	NOUN
bam-9610	23	6	in	in	ADP
bam-9610	23	7	russia	russia	PROPN
bam-9610	23	8	,	,	PUNCT
bam-9610	23	9	orphan	orphan	NOUN
bam-9610	23	10	diseases	disease	NOUN
bam-9610	23	11	are	be	AUX
bam-9610	23	12	diseases	disease	NOUN
bam-9610	23	13	whose	whose	DET
bam-9610	23	14	prevalence	prevalence	NOUN
bam-9610	23	15	is	be	AUX
bam-9610	23	16	within	within	ADP
bam-9610	23	17	10	10	NUM
bam-9610	23	18	cases	case	NOUN
bam-9610	23	19	per	per	ADP
bam-9610	23	20	100000	100000	NUM
bam-9610	23	21	persons.2	persons.2	NOUN
bam-9610	23	22	in	in	ADP
bam-9610	23	23	the	the	DET
bam-9610	23	24	countries	country	NOUN
bam-9610	23	25	of	of	ADP
bam-9610	23	26	the	the	DET
bam-9610	23	27	european	european	PROPN
bam-9610	23	28	union	union	PROPN
bam-9610	23	29	,	,	PUNCT
bam-9610	23	30	the	the	DET
bam-9610	23	31	disease	disease	NOUN
bam-9610	23	32	is	be	AUX
bam-9610	23	33	considered	consider	VERB
bam-9610	23	34	rare	rare	ADJ
bam-9610	23	35	if	if	SCONJ
bam-9610	23	36	it	it	PRON
bam-9610	23	37	affects	affect	VERB
bam-9610	23	38	less	less	ADJ
bam-9610	23	39	than	than	ADP
bam-9610	23	40	1	1	NUM
bam-9610	23	41	:	:	SYM
bam-9610	23	42	2000	2000	NUM
bam-9610	23	43	of	of	ADP
bam-9610	23	44	population	population	NOUN
bam-9610	23	45	,	,	PUNCT
bam-9610	23	46	in	in	ADP
bam-9610	23	47	the	the	DET
bam-9610	23	48	usa	usa	PROPN
bam-9610	23	49	less	less	ADJ
bam-9610	23	50	than	than	ADP
bam-9610	23	51	1	1	NUM
bam-9610	23	52	:	:	SYM
bam-9610	23	53	200000	200000	NUM
bam-9610	23	54	of	of	ADP
bam-9610	23	55	the	the	DET
bam-9610	23	56	population	population	NOUN
bam-9610	23	57	,	,	PUNCT
bam-9610	23	58	in	in	ADP
bam-9610	23	59	japan	japan	PROPN
bam-9610	23	60	less	less	ADJ
bam-9610	23	61	than	than	ADP
bam-9610	23	62	4	4	NUM
bam-9610	23	63	:	:	SYM
bam-9610	23	64	10000	10000	NUM
bam-9610	23	65	people.4,5	people.4,5	NOUN
bam-9610	23	66	between	between	ADP
bam-9610	23	67	5000	5000	NUM
bam-9610	23	68	and	and	CCONJ
bam-9610	23	69	8000	8000	NUM
bam-9610	23	70	rare	rare	ADJ
bam-9610	23	71	diseases	disease	NOUN
bam-9610	23	72	have	have	AUX
bam-9610	23	73	been	be	AUX
bam-9610	23	74	identified	identify	VERB
bam-9610	23	75	in	in	ADP
bam-9610	23	76	the	the	DET
bam-9610	23	77	world	world	NOUN
bam-9610	23	78	,	,	PUNCT
bam-9610	23	79	about	about	ADV
bam-9610	23	80	80	80	NUM
bam-9610	23	81	%	%	NOUN
bam-9610	23	82	of	of	ADP
bam-9610	23	83	them	they	PRON
bam-9610	23	84	are	be	AUX
bam-9610	23	85	of	of	ADP
bam-9610	23	86	genetic	genetic	ADJ
bam-9610	23	87	origin	origin	NOUN
bam-9610	23	88	.	.	PUNCT
bam-9610	24	1	evaluation	evaluation	NOUN
bam-9610	24	2	of	of	ADP
bam-9610	24	3	orphan	orphan	NOUN
bam-9610	24	4	diseases	disease	NOUN
bam-9610	24	5	global	global	ADJ
bam-9610	24	6	burden	burden	PROPN
bam-9610	24	7	eur	eur	PROPN
bam-9610	24	8	j	j	PROPN
bam-9610	24	9	transl	transl	PROPN
bam-9610	24	10	myol	myol	NOUN
bam-9610	24	11	2021	2021	NUM
bam-9610	24	12	;	;	PUNCT
bam-9610	24	13	31	31	NUM
bam-9610	24	14	(	(	PUNCT
bam-9610	24	15	2	2	NUM
bam-9610	24	16	):	):	PUNCT
bam-9610	24	17	9610	9610	NUM
bam-9610	24	18	.	.	PUNCT
bam-9610	25	1	doi	doi	NOUN
bam-9610	25	2	:	:	PUNCT
bam-9610	25	3	10.4081	10.4081	NUM
bam-9610	25	4	/	/	SYM
bam-9610	25	5	ejtm.2021.9610	ejtm.2021.9610	NUM
bam-9610	25	6	2	2	NUM
bam-9610	25	7	although	although	SCONJ
bam-9610	25	8	the	the	DET
bam-9610	25	9	peculiarity	peculiarity	NOUN
bam-9610	25	10	of	of	ADP
bam-9610	25	11	these	these	DET
bam-9610	25	12	diseases	disease	NOUN
bam-9610	25	13	is	be	AUX
bam-9610	25	14	that	that	SCONJ
bam-9610	25	15	they	they	PRON
bam-9610	25	16	have	have	VERB
bam-9610	25	17	a	a	DET
bam-9610	25	18	low	low	ADJ
bam-9610	25	19	incidence	incidence	NOUN
bam-9610	25	20	,	,	PUNCT
bam-9610	25	21	they	they	PRON
bam-9610	25	22	are	be	AUX
bam-9610	25	23	numerous	numerous	ADJ
bam-9610	25	24	and	and	CCONJ
bam-9610	25	25	their	their	PRON
bam-9610	25	26	overall	overall	ADJ
bam-9610	25	27	share	share	NOUN
bam-9610	25	28	in	in	ADP
bam-9610	25	29	the	the	DET
bam-9610	25	30	statistics	statistic	NOUN
bam-9610	25	31	of	of	ADP
bam-9610	25	32	disability	disability	NOUN
bam-9610	25	33	and	and	CCONJ
bam-9610	25	34	mortality	mortality	NOUN
bam-9610	25	35	is	be	AUX
bam-9610	25	36	very	very	ADV
bam-9610	25	37	high	high	ADJ
bam-9610	25	38	.	.	PUNCT
bam-9610	26	1	consequently	consequently	ADV
bam-9610	26	2	,	,	PUNCT
bam-9610	26	3	the	the	DET
bam-9610	26	4	socio	socio	NOUN
bam-9610	26	5	-	-	PUNCT
bam-9610	26	6	economic	economic	ADJ
bam-9610	26	7	burden	burden	NOUN
bam-9610	26	8	of	of	ADP
bam-9610	26	9	orphan	orphan	NOUN
bam-9610	26	10	pathology	pathology	NOUN
bam-9610	26	11	for	for	ADP
bam-9610	26	12	society	society	NOUN
bam-9610	26	13	and	and	CCONJ
bam-9610	26	14	the	the	DET
bam-9610	26	15	state	state	NOUN
bam-9610	26	16	is	be	AUX
bam-9610	26	17	also	also	ADV
bam-9610	26	18	high.3,4	high.3,4	ADJ
bam-9610	26	19	in	in	ADP
bam-9610	26	20	russia	russia	PROPN
bam-9610	26	21	,	,	PUNCT
bam-9610	26	22	at	at	ADP
bam-9610	26	23	the	the	DET
bam-9610	26	24	end	end	NOUN
bam-9610	26	25	of	of	ADP
bam-9610	26	26	2019	2019	NUM
bam-9610	26	27	,	,	PUNCT
bam-9610	26	28	the	the	DET
bam-9610	26	29	list	list	NOUN
bam-9610	26	30	of	of	ADP
bam-9610	26	31	rare	rare	ADJ
bam-9610	26	32	diseases	disease	NOUN
bam-9610	26	33	,	,	PUNCT
bam-9610	26	34	whose	whose	DET
bam-9610	26	35	treatment	treatment	NOUN
bam-9610	26	36	is	be	AUX
bam-9610	26	37	covered	cover	VERB
bam-9610	26	38	by	by	ADP
bam-9610	26	39	the	the	DET
bam-9610	26	40	state	state	NOUN
bam-9610	26	41	,	,	PUNCT
bam-9610	26	42	was	be	AUX
bam-9610	26	43	expanded	expand	VERB
bam-9610	26	44	to	to	ADP
bam-9610	26	45	14	14	NUM
bam-9610	26	46	conditions	condition	NOUN
bam-9610	26	47	(	(	PUNCT
bam-9610	26	48	hemophilia	hemophilia	PROPN
bam-9610	26	49	,	,	PUNCT
bam-9610	26	50	cystic	cystic	ADJ
bam-9610	26	51	fibrosis	fibrosis	NOUN
bam-9610	26	52	,	,	PUNCT
bam-9610	26	53	pituitary	pituitary	ADJ
bam-9610	26	54	dwarfism	dwarfism	NOUN
bam-9610	26	55	,	,	PUNCT
bam-9610	26	56	gaucher	gaucher	PROPN
bam-9610	26	57	disease	disease	NOUN
bam-9610	26	58	,	,	PUNCT
bam-9610	26	59	malignant	malignant	ADJ
bam-9610	26	60	neoplasms	neoplasm	NOUN
bam-9610	26	61	of	of	ADP
bam-9610	26	62	lymphoid	lymphoid	NOUN
bam-9610	26	63	,	,	PUNCT
bam-9610	26	64	hematopoietic	hematopoietic	ADJ
bam-9610	26	65	and	and	CCONJ
bam-9610	26	66	related	related	ADJ
bam-9610	26	67	tissues	tissue	NOUN
bam-9610	26	68	,	,	PUNCT
bam-9610	26	69	multiple	multiple	ADJ
bam-9610	26	70	sclerosis	sclerosis	NOUN
bam-9610	26	71	,	,	PUNCT
bam-9610	26	72	hemolytic	hemolytic	ADJ
bam-9610	26	73	uremic	uremic	ADJ
bam-9610	26	74	syndrome	syndrome	NOUN
bam-9610	26	75	,	,	PUNCT
bam-9610	26	76	juvenile	juvenile	ADJ
bam-9610	26	77	arthritis	arthritis	NOUN
bam-9610	26	78	with	with	ADP
bam-9610	26	79	systemic	systemic	ADJ
bam-9610	26	80	onset	onset	NOUN
bam-9610	26	81	,	,	PUNCT
bam-9610	26	82	mucopolysaccharidosis	mucopolysaccharidosis	NOUN
bam-9610	26	83	i	i	PROPN
bam-9610	26	84	,	,	PUNCT
bam-9610	26	85	ii	ii	PROPN
bam-9610	26	86	and	and	CCONJ
bam-9610	26	87	vi	vi	PROPN
bam-9610	26	88	type	type	NOUN
bam-9610	26	89	ii	ii	PROPN
bam-9610	26	90	,	,	PUNCT
bam-9610	26	91	hereditary	hereditary	ADJ
bam-9610	26	92	anemia	anemia	NOUN
bam-9610	26	93	,	,	PUNCT
bam-9610	26	94	non	non	ADJ
bam-9610	26	95	-	-	ADJ
bam-9610	26	96	aplastic	aplastic	ADJ
bam-9610	26	97	factors	factor	NOUN
bam-9610	26	98	(	(	PUNCT
bam-9610	26	99	fibrinogen	fibrinogen	NOUN
bam-9610	26	100	)	)	PUNCT
bam-9610	26	101	,	,	PUNCT
bam-9610	26	102	vii	vii	PROPN
bam-9610	26	103	(	(	PUNCT
bam-9610	26	104	labile	labile	NOUN
bam-9610	26	105	)	)	PUNCT
bam-9610	26	106	,	,	PUNCT
bam-9610	26	107	x	x	X
bam-9610	26	108	(	(	PUNCT
bam-9610	26	109	stuart	stuart	PROPN
bam-9610	26	110	-	-	PUNCT
bam-9610	26	111	prower),5	prower),5	NOUN
bam-9610	26	112	and	and	CCONJ
bam-9610	26	113	budgetary	budgetary	ADJ
bam-9610	26	114	funding	funding	NOUN
bam-9610	26	115	was	be	AUX
bam-9610	26	116	increased	increase	VERB
bam-9610	26	117	yearly	yearly	ADV
bam-9610	26	118	to	to	ADP
bam-9610	26	119	2	2	NUM
bam-9610	26	120	billion	billion	NUM
bam-9610	26	121	rubles	ruble	NOUN
bam-9610	26	122	(	(	PUNCT
bam-9610	26	123	32.300000	32.300000	NUM
bam-9610	26	124	usd	usd	NOUN
bam-9610	26	125	)	)	PUNCT
bam-9610	26	126	as	as	ADP
bam-9610	26	127	of	of	ADP
bam-9610	26	128	december	december	PROPN
bam-9610	26	129	2019	2019	NUM
bam-9610	26	130	.	.	PUNCT
bam-9610	27	1	comparative	comparative	ADJ
bam-9610	27	2	analysis	analysis	NOUN
bam-9610	27	3	of	of	ADP
bam-9610	27	4	the	the	DET
bam-9610	27	5	dynamics	dynamic	NOUN
bam-9610	27	6	of	of	ADP
bam-9610	27	7	the	the	DET
bam-9610	27	8	prevalence	prevalence	NOUN
bam-9610	27	9	of	of	ADP
bam-9610	27	10	rare	rare	ADJ
bam-9610	27	11	(	(	PUNCT
bam-9610	27	12	orphan	orphan	NOUN
bam-9610	27	13	)	)	PUNCT
bam-9610	27	14	diseases	disease	NOUN
bam-9610	27	15	in	in	ADP
bam-9610	27	16	children	child	NOUN
bam-9610	27	17	,	,	PUNCT
bam-9610	27	18	both	both	CCONJ
bam-9610	27	19	in	in	ADP
bam-9610	27	20	general	general	ADJ
bam-9610	27	21	and	and	CCONJ
bam-9610	27	22	by	by	ADP
bam-9610	27	23	individual	individual	ADJ
bam-9610	27	24	nosological	nosological	ADJ
bam-9610	27	25	forms	form	NOUN
bam-9610	27	26	according	accord	VERB
bam-9610	27	27	to	to	ADP
bam-9610	27	28	2015	2015	NUM
bam-9610	27	29	and	and	CCONJ
bam-9610	27	30	2018	2018	NUM
bam-9610	27	31	data	datum	NOUN
bam-9610	27	32	,	,	PUNCT
bam-9610	27	33	showed	show	VERB
bam-9610	27	34	that	that	SCONJ
bam-9610	27	35	the	the	DET
bam-9610	27	36	prevalence	prevalence	NOUN
bam-9610	27	37	of	of	ADP
bam-9610	27	38	rare	rare	ADJ
bam-9610	27	39	(	(	PUNCT
bam-9610	27	40	orphan	orphan	NOUN
bam-9610	27	41	)	)	PUNCT
bam-9610	27	42	diseases	disease	NOUN
bam-9610	27	43	in	in	ADP
bam-9610	27	44	children	child	NOUN
bam-9610	27	45	as	as	ADP
bam-9610	27	46	a	a	DET
bam-9610	27	47	whole	whole	NOUN
bam-9610	27	48	increased	increase	VERB
bam-9610	27	49	from	from	ADP
bam-9610	27	50	234.76	234.76	NUM
bam-9610	27	51	to	to	ADP
bam-9610	27	52	283.65	283.65	NUM
bam-9610	27	53	per	per	ADP
bam-9610	27	54	1	1	NUM
bam-9610	27	55	000	000	NUM
bam-9610	27	56	000	000	NUM
bam-9610	27	57	of	of	ADP
bam-9610	27	58	the	the	DET
bam-9610	27	59	child	child	NOUN
bam-9610	27	60	population	population	NOUN
bam-9610	27	61	(	(	PUNCT
bam-9610	27	62	by	by	ADP
bam-9610	27	63	20.8	20.8	NUM
bam-9610	27	64	%	%	NOUN
bam-9610	27	65	)	)	PUNCT
bam-9610	28	1	(	(	PUNCT
bam-9610	28	2	1	1	X
bam-9610	28	3	:	:	SYM
bam-9610	28	4	4250	4250	NUM
bam-9610	28	5	and	and	CCONJ
bam-9610	28	6	1	1	NUM
bam-9610	28	7	:	:	SYM
bam-9610	28	8	3520	3520	NUM
bam-9610	28	9	,	,	PUNCT
bam-9610	28	10	respectively	respectively	ADV
bam-9610	28	11	)	)	PUNCT
bam-9610	28	12	.	.	PUNCT
bam-9610	29	1	this	this	PRON
bam-9610	29	2	happened	happen	VERB
bam-9610	29	3	due	due	ADP
bam-9610	29	4	to	to	ADP
bam-9610	29	5	the	the	DET
bam-9610	29	6	majority	majority	NOUN
bam-9610	29	7	of	of	ADP
bam-9610	29	8	nosological	nosological	ADJ
bam-9610	29	9	forms	form	NOUN
bam-9610	29	10	(	(	PUNCT
bam-9610	29	11	figure	figure	NOUN
bam-9610	29	12	1	1	NUM
bam-9610	29	13	and	and	CCONJ
bam-9610	29	14	tables	table	NOUN
bam-9610	29	15	1	1	NUM
bam-9610	29	16	and	and	CCONJ
bam-9610	29	17	2).6	2).6	NUM
bam-9610	29	18	depending	depend	VERB
bam-9610	29	19	on	on	ADP
bam-9610	29	20	the	the	DET
bam-9610	29	21	type	type	NOUN
bam-9610	29	22	of	of	ADP
bam-9610	29	23	disease	disease	NOUN
bam-9610	29	24	,	,	PUNCT
bam-9610	29	25	a	a	DET
bam-9610	29	26	monthly	monthly	ADJ
bam-9610	29	27	course	course	NOUN
bam-9610	29	28	of	of	ADP
bam-9610	29	29	treatment	treatment	NOUN
bam-9610	29	30	and	and	CCONJ
bam-9610	29	31	/	/	SYM
bam-9610	29	32	or	or	CCONJ
bam-9610	29	33	rehabilitation	rehabilitation	NOUN
bam-9610	29	34	costs	cost	NOUN
bam-9610	29	35	from	from	ADP
bam-9610	29	36	100.000	100.000	NUM
bam-9610	29	37	rubles	ruble	NOUN
bam-9610	29	38	(	(	PUNCT
bam-9610	29	39	1400	1400	NUM
bam-9610	29	40	usd	usd	NOUN
bam-9610	29	41	)	)	PUNCT
bam-9610	29	42	up	up	ADP
bam-9610	29	43	to	to	ADP
bam-9610	29	44	several	several	ADJ
bam-9610	29	45	million	million	NUM
bam-9610	29	46	of	of	ADP
bam-9610	29	47	rubles.6	rubles.6	PROPN
bam-9610	29	48	the	the	DET
bam-9610	29	49	cost	cost	NOUN
bam-9610	29	50	of	of	ADP
bam-9610	29	51	orphan	orphan	NOUN
bam-9610	29	52	drugs	drug	NOUN
bam-9610	29	53	,	,	PUNCT
bam-9610	29	54	according	accord	VERB
bam-9610	29	55	to	to	ADP
bam-9610	29	56	european	european	ADJ
bam-9610	29	57	colleagues	colleague	NOUN
bam-9610	29	58	,	,	PUNCT
bam-9610	29	59	exceeds	exceed	VERB
bam-9610	29	60	the	the	DET
bam-9610	29	61	cost	cost	NOUN
bam-9610	29	62	of	of	ADP
bam-9610	29	63	conventional	conventional	ADJ
bam-9610	29	64	drugs	drug	NOUN
bam-9610	29	65	by	by	ADP
bam-9610	29	66	13.8	13.8	NUM
bam-9610	29	67	times.7	times.7	NOUN
bam-9610	29	68	due	due	ADP
bam-9610	29	69	to	to	ADP
bam-9610	29	70	the	the	DET
bam-9610	29	71	local	local	ADJ
bam-9610	29	72	and	and	CCONJ
bam-9610	29	73	small	small	ADJ
bam-9610	29	74	sales	sale	NOUN
bam-9610	29	75	market	market	NOUN
bam-9610	29	76	,	,	PUNCT
bam-9610	29	77	it	it	PRON
bam-9610	29	78	is	be	AUX
bam-9610	29	79	not	not	PART
bam-9610	29	80	profitable	profitable	ADJ
bam-9610	29	81	for	for	SCONJ
bam-9610	29	82	pharmaceutical	pharmaceutical	ADJ
bam-9610	29	83	companies	company	NOUN
bam-9610	29	84	to	to	PART
bam-9610	29	85	develop	develop	VERB
bam-9610	29	86	new	new	ADJ
bam-9610	29	87	drugs	drug	NOUN
bam-9610	29	88	and	and	CCONJ
bam-9610	29	89	spend	spend	VERB
bam-9610	29	90	them	they	PRON
bam-9610	29	91	on	on	ADP
bam-9610	29	92	clinical	clinical	ADJ
bam-9610	29	93	trials	trial	NOUN
bam-9610	29	94	.	.	PUNCT
bam-9610	30	1	for	for	ADP
bam-9610	30	2	very	very	ADV
bam-9610	30	3	few	few	ADJ
bam-9610	30	4	rare	rare	ADJ
bam-9610	30	5	diseases	disease	NOUN
bam-9610	30	6	,	,	PUNCT
bam-9610	30	7	specific	specific	ADJ
bam-9610	30	8	drugs	drug	NOUN
bam-9610	30	9	have	have	AUX
bam-9610	30	10	been	be	AUX
bam-9610	30	11	developed	develop	VERB
bam-9610	30	12	,	,	PUNCT
bam-9610	30	13	although	although	SCONJ
bam-9610	30	14	the	the	DET
bam-9610	30	15	use	use	NOUN
bam-9610	30	16	of	of	ADP
bam-9610	30	17	specific	specific	ADJ
bam-9610	30	18	therapy	therapy	NOUN
bam-9610	30	19	can	can	AUX
bam-9610	30	20	significantly	significantly	ADV
bam-9610	30	21	affect	affect	VERB
bam-9610	30	22	the	the	DET
bam-9610	30	23	disability	disability	NOUN
bam-9610	30	24	,	,	PUNCT
bam-9610	30	25	mortality	mortality	NOUN
bam-9610	30	26	and	and	CCONJ
bam-9610	30	27	quality	quality	NOUN
bam-9610	30	28	of	of	ADP
bam-9610	30	29	life	life	NOUN
bam-9610	30	30	of	of	ADP
bam-9610	30	31	such	such	ADJ
bam-9610	30	32	patients.2	patients.2	PROPN
bam-9610	30	33	there	there	PRON
bam-9610	30	34	are	be	VERB
bam-9610	30	35	practically	practically	ADV
bam-9610	30	36	no	no	DET
bam-9610	30	37	data	datum	NOUN
bam-9610	30	38	on	on	ADP
bam-9610	30	39	the	the	DET
bam-9610	30	40	economic	economic	ADJ
bam-9610	30	41	burden	burden	NOUN
bam-9610	30	42	and	and	CCONJ
bam-9610	30	43	global	global	ADJ
bam-9610	30	44	health	health	NOUN
bam-9610	30	45	indicators	indicator	NOUN
bam-9610	30	46	in	in	ADP
bam-9610	30	47	people	people	NOUN
bam-9610	30	48	with	with	ADP
bam-9610	30	49	rare	rare	ADJ
bam-9610	30	50	diseases	disease	NOUN
bam-9610	30	51	in	in	ADP
bam-9610	30	52	russian	russian	ADJ
bam-9610	30	53	scientific	scientific	ADJ
bam-9610	30	54	sources	source	NOUN
bam-9610	30	55	.	.	PUNCT
bam-9610	31	1	as	as	ADP
bam-9610	31	2	an	an	DET
bam-9610	31	3	example	example	NOUN
bam-9610	31	4	,	,	PUNCT
bam-9610	31	5	we	we	PRON
bam-9610	31	6	can	can	AUX
bam-9610	31	7	take	take	VERB
bam-9610	31	8	the	the	DET
bam-9610	31	9	data	datum	NOUN
bam-9610	31	10	on	on	ADP
bam-9610	31	11	hemophilia	hemophilia	PROPN
bam-9610	31	12	a	a	PRON
bam-9610	31	13	:	:	PUNCT
bam-9610	31	14	the	the	DET
bam-9610	31	15	course	course	NOUN
bam-9610	31	16	of	of	ADP
bam-9610	31	17	treatment	treatment	NOUN
bam-9610	31	18	for	for	ADP
bam-9610	31	19	which	which	PRON
bam-9610	31	20	for	for	ADP
bam-9610	31	21	a	a	DET
bam-9610	31	22	child	child	NOUN
bam-9610	31	23	ranges	range	VERB
bam-9610	31	24	from	from	ADP
bam-9610	31	25	21040	21040	NUM
bam-9610	31	26	usd	usd	NOUN
bam-9610	31	27	to	to	ADP
bam-9610	31	28	1000000	1000000	NUM
bam-9610	31	29	usd	usd	NOUN
bam-9610	31	30	per	per	ADP
bam-9610	31	31	year	year	NOUN
bam-9610	31	32	per	per	ADP
bam-9610	31	33	patient	patient	NOUN
bam-9610	31	34	,	,	PUNCT
bam-9610	31	35	and	and	CCONJ
bam-9610	31	36	for	for	ADP
bam-9610	31	37	an	an	DET
bam-9610	31	38	adult	adult	NOUN
bam-9610	31	39	from	from	ADP
bam-9610	31	40	42700	42700	NUM
bam-9610	31	41	usd	usd	NOUN
bam-9610	31	42	to	to	ADP
bam-9610	31	43	2140000	2140000	NUM
bam-9610	31	44	usd	usd	NOUN
bam-9610	31	45	per	per	ADP
bam-9610	31	46	year	year	NOUN
bam-9610	31	47	per	per	ADP
bam-9610	31	48	patient	patient	NOUN
bam-9610	31	49	.	.	PUNCT
bam-9610	32	1	the	the	DET
bam-9610	32	2	cost	cost	NOUN
bam-9610	32	3	varies	vary	VERB
bam-9610	32	4	depending	depend	VERB
bam-9610	32	5	on	on	ADP
bam-9610	32	6	the	the	DET
bam-9610	32	7	drug	drug	NOUN
bam-9610	32	8	,	,	PUNCT
bam-9610	32	9	weight	weight	NOUN
bam-9610	32	10	,	,	PUNCT
bam-9610	32	11	type	type	NOUN
bam-9610	32	12	of	of	ADP
bam-9610	32	13	disease	disease	NOUN
bam-9610	32	14	and	and	CCONJ
bam-9610	32	15	the	the	DET
bam-9610	32	16	presence	presence	NOUN
bam-9610	32	17	of	of	ADP
bam-9610	32	18	complications.8	complications.8	PROPN
bam-9610	32	19	kolbin	kolbin	PROPN
bam-9610	32	20	a.s	a.s	PROPN
bam-9610	32	21	.	.	PROPN
bam-9610	32	22	et	et	PROPN
bam-9610	32	23	al	al	PROPN
bam-9610	32	24	.	.	PUNCT
bam-9610	33	1	(	(	PUNCT
bam-9610	33	2	2018)9	2018)9	NUM
bam-9610	33	3	provides	provide	VERB
bam-9610	33	4	figures	figure	NOUN
bam-9610	33	5	for	for	ADP
bam-9610	33	6	the	the	DET
bam-9610	33	7	cost	cost	NOUN
bam-9610	33	8	of	of	ADP
bam-9610	33	9	treating	treat	VERB
bam-9610	33	10	pompe	pompe	PROPN
bam-9610	33	11	disease	disease	NOUN
bam-9610	33	12	.	.	PUNCT
bam-9610	34	1	the	the	DET
bam-9610	34	2	cost	cost	NOUN
bam-9610	34	3	of	of	ADP
bam-9610	34	4	providing	provide	VERB
bam-9610	34	5	patients	patient	NOUN
bam-9610	34	6	with	with	ADP
bam-9610	34	7	the	the	DET
bam-9610	34	8	specific	specific	ADJ
bam-9610	34	9	drug	drug	NOUN
bam-9610	34	10	alglucosidase	alglucosidase	NOUN
bam-9610	34	11	alfa	alfa	NOUN
bam-9610	34	12	as	as	SCONJ
bam-9610	34	13	enzyme	enzyme	NOUN
bam-9610	34	14	replacement	replacement	NOUN
bam-9610	34	15	therapy	therapy	NOUN
bam-9610	34	16	for	for	ADP
bam-9610	34	17	a	a	DET
bam-9610	34	18	child	child	NOUN
bam-9610	34	19	is	be	AUX
bam-9610	34	20	10131952	10131952	NUM
bam-9610	34	21	rubles	ruble	NOUN
bam-9610	34	22	or	or	CCONJ
bam-9610	34	23	131264	131264	NUM
bam-9610	34	24	usd	usd	NOUN
bam-9610	34	25	per	per	ADP
bam-9610	34	26	year	year	NOUN
bam-9610	34	27	per	per	ADP
bam-9610	34	28	patient	patient	NOUN
bam-9610	34	29	,	,	PUNCT
bam-9610	34	30	and	and	CCONJ
bam-9610	34	31	for	for	ADP
bam-9610	34	32	an	an	DET
bam-9610	34	33	adult	adult	NOUN
bam-9610	34	34	34596	34596	NUM
bam-9610	34	35	912	912	NUM
bam-9610	34	36	rubles	ruble	NOUN
bam-9610	34	37	or	or	CCONJ
bam-9610	34	38	448219	448219	NUM
bam-9610	34	39	usd	usd	NOUN
bam-9610	34	40	per	per	ADP
bam-9610	34	41	year	year	NOUN
bam-9610	34	42	per	per	ADP
bam-9610	34	43	patient	patient	NOUN
bam-9610	34	44	.	.	PUNCT
bam-9610	35	1	at	at	ADP
bam-9610	35	2	the	the	DET
bam-9610	35	3	same	same	ADJ
bam-9610	35	4	time	time	NOUN
bam-9610	35	5	,	,	PUNCT
bam-9610	35	6	it	it	PRON
bam-9610	35	7	fig	fig	VERB
bam-9610	35	8	1	1	NUM
bam-9610	35	9	.	.	PUNCT
bam-9610	36	1	increase	increase	VERB
bam-9610	36	2	in	in	ADP
bam-9610	36	3	the	the	DET
bam-9610	36	4	number	number	NOUN
bam-9610	36	5	of	of	ADP
bam-9610	36	6	patients	patient	NOUN
bam-9610	36	7	with	with	ADP
bam-9610	36	8	rare	rare	ADJ
bam-9610	36	9	diseases	disease	NOUN
bam-9610	36	10	in	in	ADP
bam-9610	36	11	russian	russian	ADJ
bam-9610	36	12	federal	federal	ADJ
bam-9610	36	13	registry	registry	NOUN
bam-9610	36	14	.	.	PUNCT
bam-9610	37	1	evaluation	evaluation	NOUN
bam-9610	37	2	of	of	ADP
bam-9610	37	3	orphan	orphan	NOUN
bam-9610	37	4	diseases	disease	NOUN
bam-9610	37	5	global	global	ADJ
bam-9610	37	6	burden	burden	PROPN
bam-9610	37	7	eur	eur	PROPN
bam-9610	37	8	j	j	PROPN
bam-9610	37	9	transl	transl	PROPN
bam-9610	37	10	myol	myol	NOUN
bam-9610	37	11	2021	2021	NUM
bam-9610	37	12	;	;	PUNCT
bam-9610	37	13	31	31	NUM
bam-9610	37	14	(	(	PUNCT
bam-9610	37	15	2	2	NUM
bam-9610	37	16	):	):	PUNCT
bam-9610	37	17	9610	9610	NUM
bam-9610	37	18	.	.	PUNCT
bam-9610	38	1	doi	doi	NOUN
bam-9610	38	2	:	:	PUNCT
bam-9610	38	3	10.4081	10.4081	NUM
bam-9610	38	4	/	/	SYM
bam-9610	38	5	ejtm.2021.9610	ejtm.2021.9610	NUM
bam-9610	38	6	3	3	NUM
bam-9610	38	7	was	be	AUX
bam-9610	38	8	concluded	conclude	VERB
bam-9610	38	9	that	that	SCONJ
bam-9610	38	10	the	the	DET
bam-9610	38	11	use	use	NOUN
bam-9610	38	12	of	of	ADP
bam-9610	38	13	a	a	DET
bam-9610	38	14	specific	specific	ADJ
bam-9610	38	15	drug	drug	NOUN
bam-9610	38	16	is	be	AUX
bam-9610	38	17	an	an	DET
bam-9610	38	18	economically	economically	ADV
bam-9610	38	19	feasible	feasible	ADJ
bam-9610	38	20	treatment	treatment	NOUN
bam-9610	38	21	option	option	NOUN
bam-9610	38	22	being	be	AUX
bam-9610	38	23	11.4	11.4	NUM
bam-9610	38	24	%	%	NOUN
bam-9610	38	25	cheaper	cheap	ADJ
bam-9610	38	26	in	in	ADP
bam-9610	38	27	comparison	comparison	NOUN
bam-9610	38	28	with	with	ADP
bam-9610	38	29	symptomatic	symptomatic	ADJ
bam-9610	38	30	therapy	therapy	NOUN
bam-9610	38	31	.	.	PUNCT
bam-9610	39	1	the	the	DET
bam-9610	39	2	costs	cost	NOUN
bam-9610	39	3	of	of	ADP
bam-9610	39	4	the	the	DET
bam-9610	39	5	health	health	NOUN
bam-9610	39	6	care	care	NOUN
bam-9610	39	7	system	system	NOUN
bam-9610	39	8	due	due	ADP
bam-9610	39	9	to	to	ADP
bam-9610	39	10	the	the	DET
bam-9610	39	11	progression	progression	NOUN
bam-9610	39	12	of	of	ADP
bam-9610	39	13	the	the	DET
bam-9610	39	14	disease	disease	NOUN
bam-9610	39	15	and	and	CCONJ
bam-9610	39	16	severe	severe	ADJ
bam-9610	39	17	complications	complication	NOUN
bam-9610	39	18	in	in	ADP
bam-9610	39	19	patients	patient	NOUN
bam-9610	39	20	with	with	ADP
bam-9610	39	21	pompe	pompe	PROPN
bam-9610	39	22	disease	disease	NOUN
bam-9610	39	23	up	up	ADP
bam-9610	39	24	to	to	ADP
bam-9610	39	25	12077545	12077545	NUM
bam-9610	39	26	rubles	ruble	NOUN
bam-9610	39	27	or	or	CCONJ
bam-9610	39	28	156470	156470	NUM
bam-9610	39	29	usd	usd	NOUN
bam-9610	39	30	per	per	ADP
bam-9610	39	31	person	person	NOUN
bam-9610	39	32	lower	low	ADJ
bam-9610	39	33	when	when	SCONJ
bam-9610	39	34	using	use	VERB
bam-9610	39	35	alglucosidase	alglucosidase	NOUN
bam-9610	39	36	alfa	alfa	NOUN
bam-9610	39	37	.	.	PUNCT
bam-9610	40	1	on	on	ADP
bam-9610	40	2	the	the	DET
bam-9610	40	3	contrary	contrary	NOUN
bam-9610	40	4	,	,	PUNCT
bam-9610	40	5	the	the	DET
bam-9610	40	6	increase	increase	NOUN
bam-9610	40	7	in	in	ADP
bam-9610	40	8	the	the	DET
bam-9610	40	9	costs	cost	NOUN
bam-9610	40	10	of	of	ADP
bam-9610	40	11	diagnostic	diagnostic	ADJ
bam-9610	40	12	and	and	CCONJ
bam-9610	40	13	rehabilitation	rehabilitation	NOUN
bam-9610	40	14	measures	measure	NOUN
bam-9610	40	15	in	in	ADP
bam-9610	40	16	patients	patient	NOUN
bam-9610	40	17	on	on	ADP
bam-9610	40	18	symptomatic	symptomatic	ADJ
bam-9610	40	19	therapy	therapy	NOUN
bam-9610	40	20	determines	determine	VERB
bam-9610	40	21	a	a	DET
bam-9610	40	22	significant	significant	ADJ
bam-9610	40	23	burden	burden	NOUN
bam-9610	40	24	on	on	ADP
bam-9610	40	25	the	the	DET
bam-9610	40	26	budget	budget	NOUN
bam-9610	40	27	of	of	ADP
bam-9610	40	28	medical	medical	ADJ
bam-9610	40	29	institutions	institution	NOUN
bam-9610	40	30	,	,	PUNCT
bam-9610	40	31	given	give	VERB
bam-9610	40	32	the	the	DET
bam-9610	40	33	severity	severity	NOUN
bam-9610	40	34	of	of	ADP
bam-9610	40	35	the	the	DET
bam-9610	40	36	course	course	NOUN
bam-9610	40	37	and	and	CCONJ
bam-9610	40	38	the	the	DET
bam-9610	40	39	deterioration	deterioration	NOUN
bam-9610	40	40	of	of	ADP
bam-9610	40	41	patients	patient	NOUN
bam-9610	40	42	'	'	PART
bam-9610	40	43	condition.9	condition.9	NOUN
bam-9610	40	44	moreover	moreover	ADV
bam-9610	40	45	,	,	PUNCT
bam-9610	40	46	this	this	PRON
bam-9610	40	47	is	be	AUX
bam-9610	40	48	just	just	ADV
bam-9610	40	49	a	a	DET
bam-9610	40	50	small	small	ADJ
bam-9610	40	51	fraction	fraction	NOUN
bam-9610	40	52	of	of	ADP
bam-9610	40	53	the	the	DET
bam-9610	40	54	numbers	number	NOUN
bam-9610	40	55	and	and	CCONJ
bam-9610	40	56	needs	need	NOUN
bam-9610	40	57	of	of	ADP
bam-9610	40	58	patients	patient	NOUN
bam-9610	40	59	with	with	ADP
bam-9610	40	60	rare	rare	ADJ
bam-9610	40	61	diseases	disease	NOUN
bam-9610	40	62	.	.	PUNCT
bam-9610	41	1	according	accord	VERB
bam-9610	41	2	to	to	ADP
bam-9610	41	3	various	various	ADJ
bam-9610	41	4	estimates	estimate	NOUN
bam-9610	41	5	,	,	PUNCT
bam-9610	41	6	from	from	ADP
bam-9610	41	7	15000	15000	NUM
bam-9610	41	8	to	to	ADP
bam-9610	41	9	1.5	1.5	NUM
bam-9610	41	10	million	million	NUM
bam-9610	41	11	people	people	NOUN
bam-9610	41	12	in	in	ADP
bam-9610	41	13	russia	russia	PROPN
bam-9610	41	14	suffer	suffer	VERB
bam-9610	41	15	from	from	ADP
bam-9610	41	16	orphan	orphan	NOUN
bam-9610	41	17	pathology.5,6	pathology.5,6	NOUN
bam-9610	41	18	such	such	DET
bam-9610	41	19	a	a	DET
bam-9610	41	20	scatter	scatter	NOUN
bam-9610	41	21	of	of	ADP
bam-9610	41	22	figures	figure	NOUN
bam-9610	41	23	is	be	AUX
bam-9610	41	24	due	due	ADJ
bam-9610	41	25	to	to	ADP
bam-9610	41	26	the	the	DET
bam-9610	41	27	table	table	NOUN
bam-9610	42	1	1	1	NUM
bam-9610	42	2	.	.	PUNCT
bam-9610	42	3	absolute	absolute	ADJ
bam-9610	42	4	numbers	number	NOUN
bam-9610	42	5	of	of	ADP
bam-9610	42	6	patients	patient	NOUN
bam-9610	42	7	and	and	CCONJ
bam-9610	42	8	prevalence	prevalence	NOUN
bam-9610	42	9	(	(	PUNCT
bam-9610	42	10	per	per	ADP
bam-9610	42	11	100.000	100.000	NUM
bam-9610	42	12	)	)	PUNCT
bam-9610	42	13	of	of	ADP
bam-9610	42	14	the	the	DET
bam-9610	42	15	most	most	ADV
bam-9610	42	16	common	common	ADJ
bam-9610	42	17	rare	rare	ADJ
bam-9610	42	18	diseases	disease	NOUN
bam-9610	42	19	in	in	ADP
bam-9610	42	20	russia	russia	PROPN
bam-9610	42	21	(	(	PUNCT
bam-9610	42	22	according	accord	VERB
bam-9610	42	23	to	to	ADP
bam-9610	42	24	russian	russian	ADJ
bam-9610	42	25	federal	federal	ADJ
bam-9610	42	26	register	register	PROPN
bam-9610	42	27	)	)	PUNCT
bam-9610	42	28	disease	disease	NOUN
bam-9610	42	29	idc-10	idc-10	PRON
bam-9610	42	30	number	number	NOUN
bam-9610	42	31	of	of	ADP
bam-9610	42	32	patients	patient	NOUN
bam-9610	42	33	with	with	ADP
bam-9610	42	34	orphan	orphan	NOUN
bam-9610	42	35	diseases	disease	NOUN
bam-9610	42	36	in	in	ADP
bam-9610	42	37	russia	russia	PROPN
bam-9610	42	38	(	(	PUNCT
bam-9610	42	39	according	accord	VERB
bam-9610	42	40	federal	federal	ADJ
bam-9610	42	41	registry	registry	NOUN
bam-9610	42	42	)	)	PUNCT
bam-9610	42	43	prevalence	prevalence	NOUN
bam-9610	42	44	in	in	ADP
bam-9610	42	45	russia	russia	PROPN
bam-9610	42	46	(	(	PUNCT
bam-9610	42	47	per	per	ADP
bam-9610	42	48	100	100	NUM
bam-9610	42	49	000	000	NUM
bam-9610	42	50	)	)	PUNCT
bam-9610	42	51	in	in	ADP
bam-9610	42	52	2019	2019	NUM
bam-9610	42	53	prevalence	prevalence	NOUN
bam-9610	42	54	abroad	abroad	ADV
bam-9610	42	55	russia	russia	PROPN
bam-9610	42	56	*	*	PUNCT
bam-9610	42	57	2015	2015	NUM
bam-9610	42	58	2019	2019	NUM
bam-9610	42	59	hemolytic	hemolytic	ADJ
bam-9610	42	60	uremic	uremic	ADJ
bam-9610	42	61	syndrome	syndrome	NOUN
bam-9610	42	62	d59.3	d59.3	NOUN
bam-9610	42	63	205	205	NUM
bam-9610	42	64	407	407	NUM
bam-9610	42	65	0.28	0.28	NUM
bam-9610	42	66	0.1	0.1	NUM
bam-9610	42	67	-	-	SYM
bam-9610	42	68	0.9	0.9	NUM
bam-9610	42	69	paroxysmal	paroxysmal	ADJ
bam-9610	42	70	nocturnal	nocturnal	ADJ
bam-9610	42	71	hemoglobinuria	hemoglobinuria	NOUN
bam-9610	42	72	(	(	PUNCT
bam-9610	42	73	markiafava	markiafava	NOUN
bam-9610	42	74	-	-	PUNCT
bam-9610	42	75	micheli	micheli	NOUN
bam-9610	42	76	)	)	PUNCT
bam-9610	42	77	d59.5	d59.5	NOUN
bam-9610	42	78	289	289	NUM
bam-9610	42	79	380	380	NUM
bam-9610	42	80	0.26	0.26	NUM
bam-9610	42	81	1	1	NUM
bam-9610	42	82	-	-	SYM
bam-9610	42	83	9	9	NUM
bam-9610	42	84	aplastic	aplastic	ADJ
bam-9610	42	85	anemia	anemia	NOUN
bam-9610	42	86	,	,	PUNCT
bam-9610	42	87	unspecified	unspecified	ADJ
bam-9610	42	88	d61.9	d61.9	PROPN
bam-9610	42	89	709	709	NUM
bam-9610	42	90	1078	1078	NUM
bam-9610	42	91	0.73	0.73	NUM
bam-9610	42	92	0.1	0.1	NUM
bam-9610	42	93	-	-	SYM
bam-9610	42	94	0.9	0.9	NUM
bam-9610	42	95	hereditary	hereditary	ADJ
bam-9610	42	96	deficiency	deficiency	NOUN
bam-9610	42	97	of	of	ADP
bam-9610	42	98	factors	factor	NOUN
bam-9610	42	99	ii	ii	PROPN
bam-9610	42	100	,	,	PUNCT
bam-9610	42	101	vii	vii	PROPN
bam-9610	42	102	,	,	PUNCT
bam-9610	42	103	x	x	PUNCT
bam-9610	42	104	d68.2	d68.2	NOUN
bam-9610	42	105	139	139	NUM
bam-9610	42	106	225	225	NUM
bam-9610	42	107	0.15	0.15	NUM
bam-9610	42	108	0.1	0.1	NUM
bam-9610	42	109	-	-	SYM
bam-9610	42	110	0.9	0.9	NUM
bam-9610	42	111	idiopathic	idiopathic	ADJ
bam-9610	42	112	thrombocytopenic	thrombocytopenic	ADJ
bam-9610	42	113	purpura	purpura	NOUN
bam-9610	42	114	(	(	PUNCT
bam-9610	42	115	evans	evans	PROPN
bam-9610	42	116	syndrome	syndrome	PROPN
bam-9610	42	117	)	)	PUNCT
bam-9610	42	118	d69.3	d69.3	PROPN
bam-9610	42	119	2860	2860	NUM
bam-9610	42	120	4002	4002	NUM
bam-9610	42	121	2.72	2.72	NUM
bam-9610	42	122	5	5	NUM
bam-9610	42	123	-	-	SYM
bam-9610	42	124	10	10	NUM
bam-9610	42	125	defect	defect	NOUN
bam-9610	42	126	in	in	ADP
bam-9610	42	127	the	the	DET
bam-9610	42	128	complement	complement	NOUN
bam-9610	42	129	system	system	NOUN
bam-9610	42	130	d84.1	d84.1	PROPN
bam-9610	42	131	117	117	NUM
bam-9610	42	132	327	327	NUM
bam-9610	42	133	0.22	0.22	NUM
bam-9610	42	134	1	1	NUM
bam-9610	42	135	-	-	SYM
bam-9610	42	136	9	9	NUM
bam-9610	42	137	premature	premature	ADJ
bam-9610	42	138	puberty	puberty	NOUN
bam-9610	42	139	of	of	ADP
bam-9610	42	140	central	central	ADJ
bam-9610	42	141	origin	origin	NOUN
bam-9610	42	142	е22.8	е22.8	NOUN
bam-9610	42	143	564	564	NUM
bam-9610	42	144	936	936	NUM
bam-9610	42	145	0.64	0.64	NUM
bam-9610	42	146	0.8	0.8	NUM
bam-9610	42	147	-	-	SYM
bam-9610	42	148	3.2	3.2	NUM
bam-9610	42	149	disorders	disorder	NOUN
bam-9610	42	150	of	of	ADP
bam-9610	42	151	aromatic	aromatic	ADJ
bam-9610	42	152	amino	amino	NOUN
bam-9610	42	153	acid	acid	NOUN
bam-9610	42	154	metabolism	metabolism	NOUN
bam-9610	42	155	(	(	PUNCT
bam-9610	42	156	classical	classical	ADJ
bam-9610	42	157	phenylketon	phenylketon	NOUN
bam-9610	42	158	uria	uria	NOUN
bam-9610	42	159	,	,	PUNCT
bam-9610	42	160	other	other	ADJ
bam-9610	42	161	types	type	NOUN
bam-9610	42	162	of	of	ADP
bam-9610	42	163	hyperphenylalaninemia	hyperphenylalaninemia	ADV
bam-9610	42	164	)	)	PUNCT
bam-9610	42	165	е70.0е70	е70.0е70	PUNCT
bam-9610	42	166	.1	.1	NUM
bam-9610	42	167	3678	3678	NUM
bam-9610	42	168	4775	4775	NUM
bam-9610	42	169	3.25	3.25	NUM
bam-9610	42	170	5	5	NUM
bam-9610	42	171	-	-	SYM
bam-9610	42	172	10	10	NUM
bam-9610	42	173	tyrosinemia	tyrosinemia	NOUN
bam-9610	42	174	е70.2	е70.2	NOUN
bam-9610	42	175	20	20	NUM
bam-9610	42	176	33	33	NUM
bam-9610	42	177	0.02	0.02	NUM
bam-9610	42	178	0.1	0.1	NUM
bam-9610	42	179	-	-	SYM
bam-9610	42	180	0.9	0.9	NUM
bam-9610	42	181	maple	maple	NOUN
bam-9610	42	182	syrup	syrup	NOUN
bam-9610	42	183	disease	disease	NOUN
bam-9610	42	184	е71.0	е71.0	PROPN
bam-9610	42	185	11	11	NUM
bam-9610	42	186	19	19	NUM
bam-9610	42	187	0.01	0.01	NUM
bam-9610	42	188	0.1	0.1	NUM
bam-9610	42	189	-	-	SYM
bam-9610	42	190	0.9	0.9	NUM
bam-9610	42	191	other	other	ADJ
bam-9610	42	192	types	type	NOUN
bam-9610	42	193	of	of	ADP
bam-9610	42	194	branchedchain	branchedchain	NOUN
bam-9610	42	195	amino	amino	NOUN
bam-9610	42	196	acid	acid	NOUN
bam-9610	42	197	metabolism	metabolism	NOUN
bam-9610	42	198	disorders	disorder	NOUN
bam-9610	42	199	(	(	PUNCT
bam-9610	42	200	isovalerian	isovalerian	ADJ
bam-9610	42	201	acidemia	acidemia	NOUN
bam-9610	42	202	,	,	PUNCT
bam-9610	42	203	methyl	methyl	PROPN
bam-9610	42	204	malonic	malonic	PROPN
bam-9610	42	205	acidemia	acidemia	NOUN
bam-9610	42	206	,	,	PUNCT
bam-9610	42	207	propionic	propionic	ADJ
bam-9610	42	208	acidemia	acidemia	NOUN
bam-9610	42	209	)	)	PUNCT
bam-9610	42	210	е71.1	е71.1	PROPN
bam-9610	42	211	20	20	NUM
bam-9610	42	212	31	31	NUM
bam-9610	42	213	0.02	0.02	NUM
bam-9610	42	214	0.1	0.1	NUM
bam-9610	42	215	-	-	SYM
bam-9610	42	216	0.9	0.9	NUM
bam-9610	42	217	*	*	PUNCT
bam-9610	42	218	prevalence	prevalence	NOUN
bam-9610	42	219	data	datum	NOUN
bam-9610	42	220	abroad	abroad	ADV
bam-9610	42	221	is	be	AUX
bam-9610	42	222	derived	derive	VERB
bam-9610	42	223	from	from	ADP
bam-9610	42	224	information	information	NOUN
bam-9610	42	225	provided	provide	VERB
bam-9610	42	226	by	by	ADP
bam-9610	42	227	european	european	ADJ
bam-9610	42	228	orphanet	orphanet	PROPN
bam-9610	42	229	information	information	NOUN
bam-9610	42	230	system	system	NOUN
bam-9610	42	231	(	(	PUNCT
bam-9610	42	232	2019	2019	NUM
bam-9610	42	233	)	)	PUNCT
bam-9610	42	234	.	.	PUNCT
bam-9610	43	1	evaluation	evaluation	NOUN
bam-9610	43	2	of	of	ADP
bam-9610	43	3	orphan	orphan	NOUN
bam-9610	43	4	diseases	disease	NOUN
bam-9610	43	5	global	global	ADJ
bam-9610	43	6	burden	burden	PROPN
bam-9610	43	7	eur	eur	PROPN
bam-9610	43	8	j	j	PROPN
bam-9610	43	9	transl	transl	PROPN
bam-9610	43	10	myol	myol	NOUN
bam-9610	43	11	2021	2021	NUM
bam-9610	43	12	;	;	PUNCT
bam-9610	43	13	31	31	NUM
bam-9610	43	14	(	(	PUNCT
bam-9610	43	15	2	2	NUM
bam-9610	43	16	):	):	PUNCT
bam-9610	43	17	9610	9610	NUM
bam-9610	43	18	.	.	PUNCT
bam-9610	44	1	doi	doi	NOUN
bam-9610	44	2	:	:	PUNCT
bam-9610	44	3	10.4081	10.4081	NUM
bam-9610	44	4	/	/	SYM
bam-9610	44	5	ejtm.2021.9610	ejtm.2021.9610	VERB
bam-9610	44	6	4	4	NUM
bam-9610	44	7	difficulties	difficulty	NOUN
bam-9610	44	8	of	of	ADP
bam-9610	44	9	the	the	DET
bam-9610	44	10	epidemiological	epidemiological	ADJ
bam-9610	44	11	assessment	assessment	NOUN
bam-9610	44	12	of	of	ADP
bam-9610	44	13	this	this	DET
bam-9610	44	14	group	group	NOUN
bam-9610	44	15	of	of	ADP
bam-9610	44	16	diseases	disease	NOUN
bam-9610	44	17	,	,	PUNCT
bam-9610	44	18	due	due	ADP
bam-9610	44	19	to	to	ADP
bam-9610	44	20	its	its	PRON
bam-9610	44	21	heterogeneity	heterogeneity	NOUN
bam-9610	44	22	,	,	PUNCT
bam-9610	44	23	difficulties	difficulty	NOUN
bam-9610	44	24	in	in	ADP
bam-9610	44	25	diagnosis	diagnosis	NOUN
bam-9610	44	26	and	and	CCONJ
bam-9610	44	27	statistical	statistical	ADJ
bam-9610	44	28	accounting	accounting	NOUN
bam-9610	44	29	for	for	ADP
bam-9610	44	30	public	public	ADJ
bam-9610	44	31	health	health	NOUN
bam-9610	44	32	.	.	PUNCT
bam-9610	45	1	walker	walker	PROPN
bam-9610	45	2	c.e	c.e	PROPN
bam-9610	45	3	.	.	PROPN
bam-9610	45	4	et	et	PROPN
bam-9610	45	5	al	al	PROPN
bam-9610	45	6	.	.	PROPN
bam-9610	46	1	(	(	PUNCT
bam-9610	46	2	2016	2016	NUM
bam-9610	46	3	)	)	PUNCT
bam-9610	46	4	made	make	VERB
bam-9610	46	5	an	an	DET
bam-9610	46	6	attempt	attempt	NOUN
bam-9610	46	7	to	to	PART
bam-9610	46	8	assess	assess	VERB
bam-9610	46	9	the	the	DET
bam-9610	46	10	problem	problem	NOUN
bam-9610	46	11	of	of	ADP
bam-9610	46	12	the	the	DET
bam-9610	46	13	global	global	ADJ
bam-9610	46	14	burden	burden	NOUN
bam-9610	46	15	of	of	ADP
bam-9610	46	16	rare	rare	ADJ
bam-9610	46	17	diseases	disease	NOUN
bam-9610	46	18	for	for	ADP
bam-9610	46	19	australia	australia	PROPN
bam-9610	46	20	,	,	PUNCT
bam-9610	46	21	when	when	SCONJ
bam-9610	46	22	analyzing	analyze	VERB
bam-9610	46	23	medical	medical	ADJ
bam-9610	46	24	databases	database	NOUN
bam-9610	46	25	,	,	PUNCT
bam-9610	46	26	441	441	NUM
bam-9610	46	27	rare	rare	ADJ
bam-9610	46	28	disease	disease	NOUN
bam-9610	46	29	codes	code	NOUN
bam-9610	46	30	and	and	CCONJ
bam-9610	46	31	a	a	DET
bam-9610	46	32	cohort	cohort	NOUN
bam-9610	46	33	of	of	ADP
bam-9610	46	34	45	45	NUM
bam-9610	46	35	213	213	NUM
bam-9610	46	36	people	people	NOUN
bam-9610	46	37	with	with	ADP
bam-9610	46	38	these	these	DET
bam-9610	46	39	diagnoses	diagnosis	NOUN
bam-9610	46	40	were	be	AUX
bam-9610	46	41	identified	identify	VERB
bam-9610	46	42	.	.	PUNCT
bam-9610	47	1	this	this	PRON
bam-9610	47	2	represented	represent	VERB
bam-9610	47	3	approximately	approximately	ADV
bam-9610	47	4	2	2	NUM
bam-9610	47	5	%	%	NOUN
bam-9610	47	6	of	of	ADP
bam-9610	47	7	the	the	DET
bam-9610	47	8	population	population	NOUN
bam-9610	47	9	of	of	ADP
bam-9610	47	10	western	western	PROPN
bam-9610	47	11	australia	australia	PROPN
bam-9610	47	12	.	.	PUNCT
bam-9610	48	1	walker	walker	PROPN
bam-9610	48	2	and	and	CCONJ
bam-9610	48	3	colleagues	colleague	NOUN
bam-9610	48	4	also	also	ADV
bam-9610	48	5	calculated	calculate	VERB
bam-9610	48	6	the	the	DET
bam-9610	48	7	impact	impact	NOUN
bam-9610	48	8	of	of	ADP
bam-9610	48	9	rare	rare	ADJ
bam-9610	48	10	diseases	disease	NOUN
bam-9610	48	11	on	on	ADP
bam-9610	48	12	the	the	DET
bam-9610	48	13	australian	australian	ADJ
bam-9610	48	14	health	health	NOUN
bam-9610	48	15	system	system	NOUN
bam-9610	48	16	:	:	PUNCT
bam-9610	48	17	hospital	hospital	NOUN
bam-9610	48	18	stays	stay	NOUN
bam-9610	48	19	associated	associate	VERB
bam-9610	48	20	with	with	ADP
bam-9610	48	21	rare	rare	ADJ
bam-9610	48	22	diseases	disease	NOUN
bam-9610	48	23	were	be	AUX
bam-9610	48	24	on	on	ADP
bam-9610	48	25	average	average	ADJ
bam-9610	48	26	3	3	NUM
bam-9610	48	27	days	day	NOUN
bam-9610	48	28	longer	long	ADV
bam-9610	48	29	than	than	ADP
bam-9610	48	30	the	the	DET
bam-9610	48	31	average	average	ADJ
bam-9610	48	32	hospital	hospital	NOUN
bam-9610	48	33	stay	stay	NOUN
bam-9610	48	34	.	.	PUNCT
bam-9610	49	1	two	two	NUM
bam-9610	49	2	percent	percent	NOUN
bam-9610	49	3	of	of	ADP
bam-9610	49	4	the	the	DET
bam-9610	49	5	population	population	NOUN
bam-9610	49	6	suffering	suffer	VERB
bam-9610	49	7	from	from	ADP
bam-9610	49	8	rare	rare	ADJ
bam-9610	49	9	diseases	disease	NOUN
bam-9610	49	10	accounted	account	VERB
bam-9610	49	11	for	for	ADP
bam-9610	49	12	4.6	4.6	NUM
bam-9610	49	13	to	to	PART
bam-9610	49	14	10.5	10.5	NUM
bam-9610	49	15	%	%	NOUN
bam-9610	49	16	of	of	ADP
bam-9610	49	17	total	total	ADJ
bam-9610	49	18	hospitalization	hospitalization	NOUN
bam-9610	49	19	costs.10	costs.10	PROPN
bam-9610	49	20	the	the	DET
bam-9610	49	21	american	american	ADJ
bam-9610	49	22	researchers	researcher	NOUN
bam-9610	49	23	confirm	confirm	VERB
bam-9610	49	24	these	these	DET
bam-9610	49	25	results	result	NOUN
bam-9610	49	26	.	.	PUNCT
bam-9610	50	1	yoon	yoon	PROPN
bam-9610	50	2	et	et	PROPN
bam-9610	50	3	al.11	al.11	PROPN
bam-9610	50	4	report	report	NOUN
bam-9610	50	5	that	that	SCONJ
bam-9610	50	6	codes	code	NOUN
bam-9610	50	7	of	of	ADP
bam-9610	50	8	birth	birth	NOUN
bam-9610	50	9	defects	defect	NOUN
bam-9610	50	10	and	and	CCONJ
bam-9610	50	11	genetic	genetic	ADJ
bam-9610	50	12	diseases	disease	NOUN
bam-9610	50	13	accounted	account	VERB
bam-9610	50	14	for	for	ADP
bam-9610	50	15	2.5	2.5	NUM
bam-9610	50	16	%	%	NOUN
bam-9610	50	17	of	of	ADP
bam-9610	50	18	childhood	childhood	NOUN
bam-9610	50	19	diseases	disease	NOUN
bam-9610	50	20	and	and	CCONJ
bam-9610	50	21	accounted	account	VERB
bam-9610	50	22	for	for	ADP
bam-9610	50	23	9	9	NUM
bam-9610	50	24	to	to	PART
bam-9610	50	25	12	12	NUM
bam-9610	50	26	%	%	NOUN
bam-9610	50	27	of	of	ADP
bam-9610	50	28	hospital	hospital	NOUN
bam-9610	50	29	admissions	admission	NOUN
bam-9610	50	30	to	to	ADP
bam-9610	50	31	pediatric	pediatric	ADJ
bam-9610	50	32	departments	department	NOUN
bam-9610	50	33	,	,	PUNCT
bam-9610	50	34	which	which	PRON
bam-9610	50	35	corresponded	correspond	VERB
bam-9610	50	36	to	to	ADP
bam-9610	50	37	16	16	NUM
bam-9610	50	38	to	to	PART
bam-9610	50	39	28	28	NUM
bam-9610	50	40	%	%	NOUN
bam-9610	50	41	of	of	ADP
bam-9610	50	42	total	total	ADJ
bam-9610	50	43	costs	cost	NOUN
bam-9610	50	44	of	of	ADP
bam-9610	50	45	inpatient	inpatient	NOUN
bam-9610	50	46	treatment	treatment	NOUN
bam-9610	50	47	.	.	PUNCT
bam-9610	51	1	in	in	ADP
bam-9610	51	2	pediatric	pediatric	ADJ
bam-9610	51	3	practice	practice	NOUN
bam-9610	51	4	,	,	PUNCT
bam-9610	51	5	rare	rare	ADJ
bam-9610	51	6	diseases	disease	NOUN
bam-9610	51	7	are	be	AUX
bam-9610	51	8	believed	believe	VERB
bam-9610	51	9	to	to	PART
bam-9610	51	10	account	account	VERB
bam-9610	51	11	for	for	ADP
bam-9610	51	12	a	a	DET
bam-9610	51	13	higher	high	ADJ
bam-9610	51	14	proportion	proportion	NOUN
bam-9610	51	15	of	of	ADP
bam-9610	51	16	hospitalizations	hospitalization	NOUN
bam-9610	51	17	and	and	CCONJ
bam-9610	51	18	costs	cost	NOUN
bam-9610	51	19	than	than	SCONJ
bam-9610	51	20	adults	adult	NOUN
bam-9610	51	21	do	do	VERB
bam-9610	51	22	.	.	PUNCT
bam-9610	52	1	research	research	NOUN
bam-9610	52	2	data	datum	NOUN
bam-9610	52	3	from	from	ADP
bam-9610	52	4	walker	walker	PROPN
bam-9610	52	5	c.e	c.e	PROPN
bam-9610	52	6	.	.	PROPN
bam-9610	52	7	confirm	confirm	VERB
bam-9610	52	8	this	this	DET
bam-9610	52	9	hypothesis	hypothesis	NOUN
bam-9610	52	10	.	.	PUNCT
bam-9610	53	1	the	the	DET
bam-9610	53	2	work	work	NOUN
bam-9610	53	3	of	of	ADP
bam-9610	53	4	his	his	PRON
bam-9610	53	5	colleagues	colleague	NOUN
bam-9610	53	6	can	can	AUX
bam-9610	53	7	be	be	AUX
bam-9610	53	8	extrapolated	extrapolate	VERB
bam-9610	53	9	to	to	ADP
bam-9610	53	10	other	other	ADJ
bam-9610	53	11	health	health	NOUN
bam-9610	53	12	care	care	NOUN
bam-9610	53	13	systems	system	NOUN
bam-9610	53	14	for	for	ADP
bam-9610	53	15	rare	rare	ADJ
bam-9610	53	16	diseases.11	diseases.11	ADJ
bam-9610	53	17	table	table	NOUN
bam-9610	53	18	2	2	NUM
bam-9610	53	19	.	.	PUNCT
bam-9610	53	20	absolute	absolute	ADJ
bam-9610	53	21	numbers	number	NOUN
bam-9610	53	22	of	of	ADP
bam-9610	53	23	patients	patient	NOUN
bam-9610	53	24	and	and	CCONJ
bam-9610	53	25	prevalence	prevalence	NOUN
bam-9610	53	26	(	(	PUNCT
bam-9610	53	27	per	per	ADP
bam-9610	53	28	100	100	NUM
bam-9610	53	29	000	000	NUM
bam-9610	53	30	)	)	PUNCT
bam-9610	53	31	of	of	ADP
bam-9610	53	32	the	the	DET
bam-9610	53	33	most	most	ADV
bam-9610	53	34	common	common	ADJ
bam-9610	53	35	rare	rare	ADJ
bam-9610	53	36	diseases	disease	NOUN
bam-9610	53	37	in	in	ADP
bam-9610	53	38	russia	russia	PROPN
bam-9610	53	39	(	(	PUNCT
bam-9610	53	40	according	accord	VERB
bam-9610	53	41	to	to	ADP
bam-9610	53	42	federal	federal	ADJ
bam-9610	53	43	register	register	NOUN
bam-9610	53	44	)	)	PUNCT
bam-9610	53	45	fatty	fatty	NOUN
bam-9610	53	46	acid	acid	NOUN
bam-9610	53	47	metabolism	metabolism	NOUN
bam-9610	53	48	disorders	disorder	NOUN
bam-9610	53	49	е71.3	е71.3	PROPN
bam-9610	53	50	30	30	NUM
bam-9610	53	51	60	60	NUM
bam-9610	53	52	0.04	0.04	NUM
bam-9610	53	53	1	1	NUM
bam-9610	53	54	-	-	SYM
bam-9610	53	55	9	9	NUM
bam-9610	53	56	homocystinuria	homocystinuria	NOUN
bam-9610	53	57	е72.1	е72.1	PROPN
bam-9610	53	58	15	15	NUM
bam-9610	53	59	26	26	NUM
bam-9610	53	60	0.02	0.02	NUM
bam-9610	53	61	1	1	NUM
bam-9610	53	62	-	-	SYM
bam-9610	53	63	9	9	NUM
bam-9610	53	64	glutaricaciduria	glutaricaciduria	NOUN
bam-9610	53	65	е72.3	е72.3	NOUN
bam-9610	53	66	40	40	NUM
bam-9610	53	67	36	36	NUM
bam-9610	53	68	0.02	0.02	NUM
bam-9610	53	69	0.1	0.1	NUM
bam-9610	53	70	-	-	SYM
bam-9610	53	71	0.9	0.9	NUM
bam-9610	53	72	galactosemia	galactosemia	NOUN
bam-9610	53	73	е74.2	е74.2	NOUN
bam-9610	53	74	267	267	NUM
bam-9610	53	75	421	421	NUM
bam-9610	53	76	0.29	0.29	NUM
bam-9610	53	77	0.21	0.21	NUM
bam-9610	53	78	other	other	ADJ
bam-9610	53	79	sphingolipidosis	sphingolipidosis	NOUN
bam-9610	53	80	:	:	PUNCT
bam-9610	53	81	fabry	fabry	NOUN
bam-9610	53	82	(	(	PUNCT
bam-9610	53	83	fabry	fabry	PROPN
bam-9610	53	84	-	-	PUNCT
bam-9610	53	85	anderson	anderson	PROPN
bam-9610	53	86	)	)	PUNCT
bam-9610	53	87	disease	disease	NOUN
bam-9610	53	88	,	,	PUNCT
bam-9610	53	89	niemann	niemann	PROPN
bam-9610	53	90	-	-	PUNCT
bam-9610	53	91	pick	pick	NOUN
bam-9610	53	92	е75.2	е75.2	PROPN
bam-9610	53	93	66	66	NUM
bam-9610	53	94	141	141	NUM
bam-9610	53	95	0,10	0,10	NOUN
bam-9610	53	96	1	1	NUM
bam-9610	53	97	-	-	SYM
bam-9610	53	98	9	9	NUM
bam-9610	53	99	mucopolysaccharidosis	mucopolysaccharidosis	NOUN
bam-9610	53	100	,	,	PUNCT
bam-9610	53	101	type	type	NOUN
bam-9610	54	1	i	i	PRON
bam-9610	54	2	е76.0	е76.0	PROPN
bam-9610	54	3	66	66	NUM
bam-9610	54	4	101	101	NUM
bam-9610	54	5	0.07	0.07	NUM
bam-9610	54	6	0.1	0.1	NUM
bam-9610	54	7	-	-	SYM
bam-9610	54	8	0.9	0.9	NUM
bam-9610	54	9	mucopolysaccharidosis	mucopolysaccharidosis	NOUN
bam-9610	54	10	,	,	PUNCT
bam-9610	54	11	type	type	NOUN
bam-9610	54	12	ii	ii	PROPN
bam-9610	54	13	е76.1	е76.1	NOUN
bam-9610	54	14	98	98	NUM
bam-9610	54	15	121	121	NUM
bam-9610	54	16	0.08	0.08	NUM
bam-9610	54	17	0.9	0.9	NUM
bam-9610	54	18	-	-	SYM
bam-9610	54	19	1.6	1.6	NUM
bam-9610	54	20	mucopolysaccharidosis	mucopolysaccharidosis	NOUN
bam-9610	54	21	,	,	PUNCT
bam-9610	54	22	type	type	NOUN
bam-9610	54	23	vi	vi	PROPN
bam-9610	55	1	е76.2	е76.2	PROPN
bam-9610	55	2	46	46	NUM
bam-9610	55	3	53	53	NUM
bam-9610	55	4	0.04	0.04	NUM
bam-9610	55	5	0.1	0.1	NUM
bam-9610	55	6	-	-	SYM
bam-9610	55	7	0.9	0.9	NUM
bam-9610	55	8	acute	acute	NOUN
bam-9610	55	9	intermittent	intermittent	NOUN
bam-9610	55	10	(	(	PUNCT
bam-9610	55	11	hepatic	hepatic	NOUN
bam-9610	55	12	)	)	PUNCT
bam-9610	55	13	porphyria	porphyria	NOUN
bam-9610	55	14	е80.2	е80.2	PROPN
bam-9610	55	15	50	50	NUM
bam-9610	55	16	100	100	NUM
bam-9610	55	17	0.07	0.07	NUM
bam-9610	55	18	1	1	NUM
bam-9610	55	19	-	-	SYM
bam-9610	55	20	5	5	NUM
bam-9610	55	21	copper	copper	NOUN
bam-9610	55	22	metabolism	metabolism	NOUN
bam-9610	55	23	disorders	disorder	NOUN
bam-9610	55	24	(	(	PUNCT
bam-9610	55	25	wilson	wilson	PROPN
bam-9610	55	26	's	's	PART
bam-9610	55	27	disease	disease	NOUN
bam-9610	55	28	)	)	PUNCT
bam-9610	55	29	е83.0	е83.0	PROPN
bam-9610	55	30	602	602	NUM
bam-9610	55	31	811	811	NUM
bam-9610	55	32	0.55	0.55	NUM
bam-9610	55	33	1	1	NUM
bam-9610	55	34	-	-	SYM
bam-9610	55	35	9	9	NUM
bam-9610	55	36	incomplete	incomplete	ADJ
bam-9610	55	37	(	(	PUNCT
bam-9610	55	38	imperfect	imperfect	ADJ
bam-9610	55	39	)	)	PUNCT
bam-9610	55	40	osteogenesis	osteogenesis	NOUN
bam-9610	55	41	q78.0	q78.0	PROPN
bam-9610	55	42	560	560	NUM
bam-9610	55	43	736	736	NUM
bam-9610	55	44	0.50	0.50	NUM
bam-9610	55	45	5	5	NUM
bam-9610	55	46	-	-	SYM
bam-9610	55	47	10	10	NUM
bam-9610	55	48	pulmonary	pulmonary	NOUN
bam-9610	55	49	(	(	PUNCT
bam-9610	55	50	arterial	arterial	NOUN
bam-9610	55	51	)	)	PUNCT
bam-9610	55	52	hypertension	hypertension	NOUN
bam-9610	55	53	(	(	PUNCT
bam-9610	55	54	idiopathic	idiopathic	ADJ
bam-9610	55	55	)	)	PUNCT
bam-9610	55	56	(	(	PUNCT
bam-9610	55	57	primary	primary	NOUN
bam-9610	55	58	)	)	PUNCT
bam-9610	55	59	i27.0	i27.0	PROPN
bam-9610	56	1	519	519	NUM
bam-9610	56	2	749	749	NUM
bam-9610	56	3	0.51	0.51	NUM
bam-9610	56	4	1	1	NUM
bam-9610	56	5	-	-	SYM
bam-9610	56	6	9	9	NUM
bam-9610	56	7	systemic	systemic	ADJ
bam-9610	56	8	-	-	PUNCT
bam-9610	56	9	onset	onset	NOUN
bam-9610	56	10	juvenile	juvenile	ADJ
bam-9610	56	11	arthritis	arthritis	NOUN
bam-9610	56	12	м08.2	м08.2	PROPN
bam-9610	56	13	1058	1058	NUM
bam-9610	56	14	1406	1406	NUM
bam-9610	56	15	0.96	0.96	NUM
bam-9610	56	16	1	1	NUM
bam-9610	56	17	-	-	SYM
bam-9610	56	18	9	9	NUM
bam-9610	56	19	total	total	NOUN
bam-9610	56	20	12029	12029	NUM
bam-9610	56	21	16973	16973	NUM
bam-9610	56	22	11.56	11.56	NUM
bam-9610	56	23	*	*	PUNCT
bam-9610	56	24	prevalence	prevalence	NOUN
bam-9610	56	25	data	datum	NOUN
bam-9610	56	26	abroad	abroad	ADV
bam-9610	56	27	is	be	AUX
bam-9610	56	28	derived	derive	VERB
bam-9610	56	29	from	from	ADP
bam-9610	56	30	information	information	NOUN
bam-9610	56	31	provided	provide	VERB
bam-9610	56	32	by	by	ADP
bam-9610	56	33	european	european	ADJ
bam-9610	56	34	orphanet	orphanet	PROPN
bam-9610	56	35	information	information	NOUN
bam-9610	56	36	system	system	NOUN
bam-9610	56	37	(	(	PUNCT
bam-9610	56	38	2019).3	2019).3	NUM
bam-9610	56	39	evaluation	evaluation	NOUN
bam-9610	56	40	of	of	ADP
bam-9610	56	41	orphan	orphan	NOUN
bam-9610	56	42	diseases	disease	NOUN
bam-9610	56	43	global	global	ADJ
bam-9610	56	44	burden	burden	PROPN
bam-9610	56	45	eur	eur	PROPN
bam-9610	56	46	j	j	PROPN
bam-9610	56	47	transl	transl	PROPN
bam-9610	56	48	myol	myol	NOUN
bam-9610	56	49	2021	2021	NUM
bam-9610	56	50	;	;	PUNCT
bam-9610	56	51	31	31	NUM
bam-9610	56	52	(	(	PUNCT
bam-9610	56	53	2	2	NUM
bam-9610	56	54	):	):	PUNCT
bam-9610	56	55	9610	9610	NUM
bam-9610	56	56	.	.	PUNCT
bam-9610	57	1	doi	doi	NOUN
bam-9610	57	2	:	:	PUNCT
bam-9610	57	3	10.4081	10.4081	NUM
bam-9610	57	4	/	/	SYM
bam-9610	57	5	ejtm.2021.9610	ejtm.2021.9610	NUM
bam-9610	57	6	5	5	NUM
bam-9610	57	7	the	the	DET
bam-9610	57	8	global	global	ADJ
bam-9610	57	9	burden	burden	NOUN
bam-9610	57	10	of	of	ADP
bam-9610	57	11	disease	disease	NOUN
bam-9610	57	12	in	in	ADP
bam-9610	57	13	1990	1990	NUM
bam-9610	57	14	,	,	PUNCT
bam-9610	57	15	the	the	DET
bam-9610	57	16	world	world	PROPN
bam-9610	57	17	health	health	NOUN
bam-9610	57	18	organization	organization	NOUN
bam-9610	57	19	(	(	PUNCT
bam-9610	57	20	who	who	PRON
bam-9610	57	21	)	)	PUNCT
bam-9610	57	22	,	,	PUNCT
bam-9610	57	23	together	together	ADV
bam-9610	57	24	with	with	ADP
bam-9610	57	25	the	the	DET
bam-9610	57	26	world	world	PROPN
bam-9610	57	27	bank	bank	NOUN
bam-9610	57	28	,	,	PUNCT
bam-9610	57	29	initiated	initiate	VERB
bam-9610	57	30	the	the	DET
bam-9610	57	31	global	global	ADJ
bam-9610	57	32	burden	burden	NOUN
bam-9610	57	33	of	of	ADP
bam-9610	57	34	disease	disease	NOUN
bam-9610	57	35	(	(	PUNCT
bam-9610	57	36	gbd	gbd	NOUN
bam-9610	57	37	)	)	PUNCT
bam-9610	57	38	project.12,13	project.12,13	NOUN
bam-9610	57	39	the	the	DET
bam-9610	57	40	purpose	purpose	NOUN
bam-9610	57	41	of	of	ADP
bam-9610	57	42	those	those	DET
bam-9610	57	43	studies	study	NOUN
bam-9610	57	44	were	be	AUX
bam-9610	57	45	to	to	PART
bam-9610	57	46	solve	solve	VERB
bam-9610	57	47	three	three	NUM
bam-9610	57	48	main	main	ADJ
bam-9610	57	49	tasks	task	NOUN
bam-9610	57	50	:	:	PUNCT
bam-9610	57	51	i	i	NOUN
bam-9610	57	52	)	)	PUNCT
bam-9610	57	53	provide	provide	VERB
bam-9610	57	54	information	information	NOUN
bam-9610	57	55	on	on	ADP
bam-9610	57	56	non	non	ADJ
bam-9610	57	57	-	-	ADJ
bam-9610	57	58	fatal	fatal	ADJ
bam-9610	57	59	disease	disease	NOUN
bam-9610	57	60	outcomes	outcome	NOUN
bam-9610	57	61	for	for	ADP
bam-9610	57	62	international	international	ADJ
bam-9610	57	63	health	health	NOUN
bam-9610	57	64	policy	policy	NOUN
bam-9610	57	65	discussion	discussion	NOUN
bam-9610	57	66	;	;	PUNCT
bam-9610	57	67	ii	ii	X
bam-9610	57	68	)	)	PUNCT
bam-9610	57	69	develop	develop	VERB
bam-9610	57	70	objective	objective	ADJ
bam-9610	57	71	epidemiological	epidemiological	ADJ
bam-9610	57	72	assessment	assessment	NOUN
bam-9610	57	73	criteria	criterion	NOUN
bam-9610	57	74	;	;	PUNCT
bam-9610	57	75	iii	iii	X
bam-9610	57	76	)	)	PUNCT
bam-9610	57	77	quantify	quantify	VERB
bam-9610	57	78	the	the	DET
bam-9610	57	79	burden	burden	NOUN
bam-9610	57	80	of	of	ADP
bam-9610	57	81	disease	disease	NOUN
bam-9610	57	82	and	and	CCONJ
bam-9610	57	83	its	its	PRON
bam-9610	57	84	economic	economic	ADJ
bam-9610	57	85	significance	significance	NOUN
bam-9610	57	86	.	.	PUNCT
bam-9610	58	1	a	a	DET
bam-9610	58	2	number	number	NOUN
bam-9610	58	3	of	of	ADP
bam-9610	58	4	metrics	metric	NOUN
bam-9610	58	5	have	have	AUX
bam-9610	58	6	been	be	AUX
bam-9610	58	7	introduced	introduce	VERB
bam-9610	58	8	as	as	ADP
bam-9610	58	9	quantitative	quantitative	ADJ
bam-9610	58	10	assessment	assessment	NOUN
bam-9610	58	11	criteria	criterion	NOUN
bam-9610	58	12	.	.	PUNCT
bam-9610	59	1	one	one	NUM
bam-9610	59	2	of	of	ADP
bam-9610	59	3	the	the	DET
bam-9610	59	4	main	main	ADJ
bam-9610	59	5	ones	one	NOUN
bam-9610	59	6	was	be	AUX
bam-9610	59	7	qaly	qaly	NOUN
bam-9610	59	8	(	(	PUNCT
bam-9610	59	9	quality	quality	NOUN
bam-9610	59	10	adjusted	adjust	VERB
bam-9610	59	11	life	life	NOUN
bam-9610	59	12	-	-	PUNCT
bam-9610	59	13	years	year	NOUN
bam-9610	59	14	)	)	PUNCT
bam-9610	59	15	–	–	PUNCT
bam-9610	59	16	years	year	NOUN
bam-9610	59	17	of	of	ADP
bam-9610	59	18	life	life	NOUN
bam-9610	59	19	adjusted	adjust	VERB
bam-9610	59	20	for	for	ADP
bam-9610	59	21	quality	quality	NOUN
bam-9610	59	22	.	.	PUNCT
bam-9610	60	1	qaly	qaly	PROPN
bam-9610	60	2	is	be	AUX
bam-9610	60	3	a	a	DET
bam-9610	60	4	score	score	NOUN
bam-9610	60	5	calculated	calculate	VERB
bam-9610	60	6	to	to	PART
bam-9610	60	7	compare	compare	VERB
bam-9610	60	8	different	different	ADJ
bam-9610	60	9	diseases	disease	NOUN
bam-9610	60	10	and	and	CCONJ
bam-9610	60	11	health	health	NOUN
bam-9610	60	12	interventions	intervention	NOUN
bam-9610	60	13	,	,	PUNCT
bam-9610	60	14	which	which	PRON
bam-9610	60	15	takes	take	VERB
bam-9610	60	16	into	into	ADP
bam-9610	60	17	account	account	NOUN
bam-9610	60	18	the	the	DET
bam-9610	60	19	average	average	ADJ
bam-9610	60	20	quality	quality	NOUN
bam-9610	60	21	of	of	ADP
bam-9610	60	22	life	life	NOUN
bam-9610	60	23	expectancy	expectancy	NOUN
bam-9610	60	24	.	.	PUNCT
bam-9610	61	1	for	for	ADP
bam-9610	61	2	example	example	NOUN
bam-9610	61	3	,	,	PUNCT
bam-9610	61	4	one	one	NUM
bam-9610	61	5	year	year	NOUN
bam-9610	61	6	of	of	ADP
bam-9610	61	7	ideal	ideal	ADJ
bam-9610	61	8	health	health	NOUN
bam-9610	61	9	equals	equal	VERB
bam-9610	61	10	one	one	NUM
bam-9610	61	11	qaly	qaly	NOUN
bam-9610	61	12	,	,	PUNCT
bam-9610	61	13	deaths	death	NOUN
bam-9610	61	14	equals	equal	VERB
bam-9610	61	15	zero	zero	NUM
bam-9610	61	16	qaly	qaly	NOUN
bam-9610	61	17	,	,	PUNCT
bam-9610	61	18	and	and	CCONJ
bam-9610	61	19	a	a	DET
bam-9610	61	20	year	year	NOUN
bam-9610	61	21	lived	live	VERB
bam-9610	61	22	in	in	ADP
bam-9610	61	23	a	a	DET
bam-9610	61	24	worse	bad	ADJ
bam-9610	61	25	than	than	SCONJ
bam-9610	61	26	ideal	ideal	ADJ
bam-9610	61	27	condition	condition	NOUN
bam-9610	61	28	is	be	AUX
bam-9610	61	29	graded	grade	VERB
bam-9610	61	30	from	from	ADP
bam-9610	61	31	0	0	NUM
bam-9610	61	32	to	to	ADP
bam-9610	61	33	1	1	NUM
bam-9610	61	34	.	.	PUNCT
bam-9610	62	1	the	the	DET
bam-9610	62	2	cost	cost	NOUN
bam-9610	62	3	of	of	ADP
bam-9610	62	4	qalys	qaly	NOUN
bam-9610	62	5	for	for	ADP
bam-9610	62	6	each	each	DET
bam-9610	62	7	individual	individual	ADJ
bam-9610	62	8	nosology	nosology	NOUN
bam-9610	62	9	is	be	AUX
bam-9610	62	10	of	of	ADP
bam-9610	62	11	great	great	ADJ
bam-9610	62	12	importance	importance	NOUN
bam-9610	62	13	for	for	ADP
bam-9610	62	14	the	the	DET
bam-9610	62	15	distribution	distribution	NOUN
bam-9610	62	16	of	of	ADP
bam-9610	62	17	health	health	NOUN
bam-9610	62	18	care	care	NOUN
bam-9610	62	19	resources	resource	NOUN
bam-9610	62	20	.	.	PUNCT
bam-9610	63	1	daly	daly	NOUN
bam-9610	63	2	(	(	PUNCT
bam-9610	63	3	disability	disability	NOUN
bam-9610	63	4	adjusted	adjust	VERB
bam-9610	63	5	life	life	NOUN
bam-9610	63	6	-	-	PUNCT
bam-9610	63	7	years	year	NOUN
bam-9610	63	8	)	)	PUNCT
bam-9610	63	9	years	year	NOUN
bam-9610	63	10	of	of	ADP
bam-9610	63	11	life	life	NOUN
bam-9610	63	12	adjusted	adjust	VERB
bam-9610	63	13	for	for	ADP
bam-9610	63	14	disability	disability	NOUN
bam-9610	63	15	,	,	PUNCT
bam-9610	63	16	has	have	AUX
bam-9610	63	17	become	become	VERB
bam-9610	63	18	another	another	DET
bam-9610	63	19	concept	concept	NOUN
bam-9610	63	20	for	for	ADP
bam-9610	63	21	assessing	assess	VERB
bam-9610	63	22	global	global	ADJ
bam-9610	63	23	health	health	NOUN
bam-9610	63	24	in	in	ADP
bam-9610	63	25	research	research	NOUN
bam-9610	63	26	.	.	PUNCT
bam-9610	64	1	one	one	NUM
bam-9610	64	2	daly	daly	NOUN
bam-9610	64	3	represents	represent	VERB
bam-9610	64	4	one	one	NUM
bam-9610	64	5	wasted	waste	VERB
bam-9610	64	6	year	year	NOUN
bam-9610	64	7	of	of	ADP
bam-9610	64	8	healthy	healthy	ADJ
bam-9610	64	9	life	life	NOUN
bam-9610	64	10	.	.	PUNCT
bam-9610	65	1	daly	daly	PROPN
bam-9610	65	2	indicator	indicator	PROPN
bam-9610	65	3	can	can	AUX
bam-9610	65	4	be	be	AUX
bam-9610	65	5	viewed	view	VERB
bam-9610	65	6	as	as	ADP
bam-9610	65	7	the	the	DET
bam-9610	65	8	gap	gap	NOUN
bam-9610	65	9	between	between	ADP
bam-9610	65	10	the	the	DET
bam-9610	65	11	current	current	ADJ
bam-9610	65	12	state	state	NOUN
bam-9610	65	13	of	of	ADP
bam-9610	65	14	health	health	NOUN
bam-9610	65	15	and	and	CCONJ
bam-9610	65	16	the	the	DET
bam-9610	65	17	ideal	ideal	ADJ
bam-9610	65	18	situation	situation	NOUN
bam-9610	65	19	when	when	SCONJ
bam-9610	65	20	the	the	DET
bam-9610	65	21	entire	entire	ADJ
bam-9610	65	22	population	population	NOUN
bam-9610	65	23	survives	survive	VERB
bam-9610	65	24	to	to	ADP
bam-9610	65	25	old	old	ADJ
bam-9610	65	26	age	age	NOUN
bam-9610	65	27	,	,	PUNCT
bam-9610	65	28	without	without	ADP
bam-9610	65	29	limiting	limit	VERB
bam-9610	65	30	its	its	PRON
bam-9610	65	31	functionality	functionality	NOUN
bam-9610	65	32	.	.	PUNCT
bam-9610	66	1	for	for	ADP
bam-9610	66	2	illness	illness	NOUN
bam-9610	66	3	,	,	PUNCT
bam-9610	66	4	condition	condition	NOUN
bam-9610	66	5	or	or	CCONJ
bam-9610	66	6	injury	injury	NOUN
bam-9610	66	7	,	,	PUNCT
bam-9610	66	8	dalys	daly	NOUN
bam-9610	66	9	are	be	AUX
bam-9610	66	10	calculated	calculate	VERB
bam-9610	66	11	as	as	ADP
bam-9610	66	12	the	the	DET
bam-9610	66	13	sum	sum	NOUN
bam-9610	66	14	of	of	ADP
bam-9610	66	15	years	year	NOUN
bam-9610	66	16	of	of	ADP
bam-9610	66	17	life	life	NOUN
bam-9610	66	18	lost	lose	VERB
bam-9610	66	19	(	(	PUNCT
bam-9610	66	20	yll	yll	NOUN
bam-9610	66	21	)	)	PUNCT
bam-9610	66	22	due	due	ADP
bam-9610	66	23	to	to	ADP
bam-9610	66	24	premature	premature	ADJ
bam-9610	66	25	mortality	mortality	NOUN
bam-9610	66	26	of	of	ADP
bam-9610	66	27	lost	lose	VERB
bam-9610	66	28	years	year	NOUN
bam-9610	66	29	due	due	ADP
bam-9610	66	30	to	to	ADP
bam-9610	66	31	disability	disability	NOUN
bam-9610	66	32	(	(	PUNCT
bam-9610	66	33	yld	yld	PROPN
bam-9610	66	34	)	)	PUNCT
bam-9610	66	35	.	.	PUNCT
bam-9610	67	1	thus	thus	ADV
bam-9610	67	2	,	,	PUNCT
bam-9610	67	3	daly	daly	NOUN
bam-9610	67	4	=	=	SYM
bam-9610	67	5	yll	yll	PROPN
bam-9610	67	6	+	+	CCONJ
bam-9610	67	7	yld	yld	PROPN
bam-9610	67	8	.	.	PROPN
bam-9610	67	9	yll	yll	PROPN
bam-9610	67	10	is	be	AUX
bam-9610	67	11	the	the	DET
bam-9610	67	12	number	number	NOUN
bam-9610	67	13	of	of	ADP
bam-9610	67	14	deaths	death	NOUN
bam-9610	67	15	from	from	ADP
bam-9610	67	16	a	a	DET
bam-9610	67	17	specific	specific	ADJ
bam-9610	67	18	disease	disease	NOUN
bam-9610	67	19	times	times	ADP
bam-9610	67	20	the	the	DET
bam-9610	67	21	average	average	ADJ
bam-9610	67	22	life	life	NOUN
bam-9610	67	23	expectancy	expectancy	NOUN
bam-9610	67	24	.	.	PUNCT
bam-9610	68	1	yll	yll	PROPN
bam-9610	68	2	considers	consider	VERB
bam-9610	68	3	cause	cause	NOUN
bam-9610	68	4	of	of	ADP
bam-9610	68	5	death	death	NOUN
bam-9610	68	6	,	,	PUNCT
bam-9610	68	7	age	age	NOUN
bam-9610	68	8	and	and	CCONJ
bam-9610	68	9	gender	gender	NOUN
bam-9610	68	10	.	.	PUNCT
bam-9610	69	1	yll	yll	NOUN
bam-9610	69	2	=	=	PUNCT
bam-9610	69	3	n	n	PROPN
bam-9610	69	4	x	x	PROPN
bam-9610	69	5	l	l	NOUN
bam-9610	69	6	,	,	PUNCT
bam-9610	70	1	where	where	SCONJ
bam-9610	70	2	:	:	PUNCT
bam-9610	70	3	n	n	NOUN
bam-9610	70	4	=	=	NOUN
bam-9610	70	5	number	number	NOUN
bam-9610	70	6	of	of	ADP
bam-9610	70	7	deaths	death	NOUN
bam-9610	70	8	and	and	CCONJ
bam-9610	70	9	l	l	NOUN
bam-9610	70	10	=	=	PUNCT
bam-9610	70	11	average	average	ADJ
bam-9610	70	12	life	life	NOUN
bam-9610	70	13	expectancy	expectancy	NOUN
bam-9610	70	14	in	in	ADP
bam-9610	70	15	years	year	NOUN
bam-9610	70	16	.	.	PUNCT
bam-9610	71	1	to	to	PART
bam-9610	71	2	determine	determine	VERB
bam-9610	71	3	the	the	DET
bam-9610	71	4	yld	yld	NOUN
bam-9610	71	5	for	for	ADP
bam-9610	71	6	a	a	DET
bam-9610	71	7	specific	specific	ADJ
bam-9610	71	8	condition	condition	NOUN
bam-9610	71	9	over	over	ADP
bam-9610	71	10	a	a	DET
bam-9610	71	11	certain	certain	ADJ
bam-9610	71	12	time	time	NOUN
bam-9610	71	13	period	period	NOUN
bam-9610	71	14	,	,	PUNCT
bam-9610	71	15	the	the	DET
bam-9610	71	16	number	number	NOUN
bam-9610	71	17	of	of	ADP
bam-9610	71	18	cases	case	NOUN
bam-9610	71	19	of	of	ADP
bam-9610	71	20	the	the	DET
bam-9610	71	21	disease	disease	NOUN
bam-9610	71	22	in	in	ADP
bam-9610	71	23	that	that	DET
bam-9610	71	24	period	period	NOUN
bam-9610	71	25	is	be	AUX
bam-9610	71	26	taken	take	VERB
bam-9610	71	27	,	,	PUNCT
bam-9610	71	28	multiplied	multiply	VERB
bam-9610	71	29	by	by	ADP
bam-9610	71	30	the	the	DET
bam-9610	71	31	average	average	ADJ
bam-9610	71	32	life	life	NOUN
bam-9610	71	33	expectancy	expectancy	NOUN
bam-9610	71	34	with	with	ADP
bam-9610	71	35	this	this	DET
bam-9610	71	36	disease	disease	NOUN
bam-9610	71	37	and	and	CCONJ
bam-9610	71	38	a	a	DET
bam-9610	71	39	coefficient	coefficient	NOUN
bam-9610	71	40	reflecting	reflect	VERB
bam-9610	71	41	the	the	DET
bam-9610	71	42	severity	severity	NOUN
bam-9610	71	43	of	of	ADP
bam-9610	71	44	the	the	DET
bam-9610	71	45	disease	disease	NOUN
bam-9610	71	46	on	on	ADP
bam-9610	71	47	a	a	DET
bam-9610	71	48	scale	scale	NOUN
bam-9610	71	49	from	from	ADP
bam-9610	71	50	0	0	NUM
bam-9610	71	51	(	(	PUNCT
bam-9610	71	52	ideal	ideal	ADJ
bam-9610	71	53	health	health	NOUN
bam-9610	71	54	)	)	PUNCT
bam-9610	71	55	to	to	ADP
bam-9610	71	56	1	1	NUM
bam-9610	71	57	(	(	PUNCT
bam-9610	71	58	death	death	NOUN
bam-9610	71	59	)	)	PUNCT
bam-9610	71	60	.	.	PUNCT
bam-9610	72	1	basic	basic	ADJ
bam-9610	72	2	formula	formula	NOUN
bam-9610	72	3	for	for	ADP
bam-9610	72	4	yld	yld	PROPN
bam-9610	72	5	is	be	AUX
bam-9610	72	6	:	:	PUNCT
bam-9610	72	7	yld	yld	PROPN
bam-9610	72	8	=	=	PUNCT
bam-9610	72	9	i	i	NOUN
bam-9610	72	10	x	x	PUNCT
bam-9610	72	11	dw	dw	X
bam-9610	72	12	x	x	PROPN
bam-9610	72	13	l	l	NOUN
bam-9610	72	14	,	,	PUNCT
bam-9610	72	15	where	where	SCONJ
bam-9610	72	16	:	:	PUNCT
bam-9610	72	17	i	i	PRON
bam-9610	72	18	=	=	NOUN
bam-9610	72	19	number	number	NOUN
bam-9610	72	20	of	of	ADP
bam-9610	72	21	cases	case	NOUN
bam-9610	72	22	,	,	PUNCT
bam-9610	72	23	dw	dw	NOUN
bam-9610	72	24	=	=	PUNCT
bam-9610	72	25	weight	weight	NOUN
bam-9610	72	26	of	of	ADP
bam-9610	72	27	disability	disability	NOUN
bam-9610	72	28	,	,	PUNCT
bam-9610	72	29	l	l	NOUN
bam-9610	73	1	=	=	PUNCT
bam-9610	73	2	mean	mean	VERB
bam-9610	73	3	duration	duration	NOUN
bam-9610	73	4	of	of	ADP
bam-9610	73	5	illness	illness	NOUN
bam-9610	73	6	before	before	ADP
bam-9610	73	7	remission	remission	NOUN
bam-9610	73	8	or	or	CCONJ
bam-9610	73	9	death	death	NOUN
bam-9610	73	10	(	(	PUNCT
bam-9610	73	11	years	year	NOUN
bam-9610	73	12	)	)	PUNCT
bam-9610	73	13	.	.	PUNCT
bam-9610	74	1	examining	examine	VERB
bam-9610	74	2	current	current	ADJ
bam-9610	74	3	dalys	daly	NOUN
bam-9610	74	4	and	and	CCONJ
bam-9610	74	5	their	their	PRON
bam-9610	74	6	dynamics	dynamic	NOUN
bam-9610	74	7	allows	allow	VERB
bam-9610	74	8	you	you	PRON
bam-9610	74	9	to	to	PART
bam-9610	74	10	quickly	quickly	ADV
bam-9610	74	11	compare	compare	VERB
bam-9610	74	12	the	the	DET
bam-9610	74	13	burden	burden	NOUN
bam-9610	74	14	of	of	ADP
bam-9610	74	15	different	different	ADJ
bam-9610	74	16	diseases	disease	NOUN
bam-9610	74	17	and	and	CCONJ
bam-9610	74	18	injuries	injury	NOUN
bam-9610	74	19	.	.	PUNCT
bam-9610	75	1	for	for	ADP
bam-9610	75	2	a	a	DET
bam-9610	75	3	complete	complete	ADJ
bam-9610	75	4	picture	picture	NOUN
bam-9610	75	5	,	,	PUNCT
bam-9610	75	6	the	the	DET
bam-9610	75	7	researchers	researcher	NOUN
bam-9610	75	8	additionally	additionally	ADV
bam-9610	75	9	use	use	VERB
bam-9610	75	10	the	the	DET
bam-9610	75	11	opposite	opposite	ADJ
bam-9610	75	12	parameter	parameter	NOUN
bam-9610	75	13	hale	hale	PROPN
bam-9610	75	14	(	(	PUNCT
bam-9610	75	15	healthy	healthy	ADJ
bam-9610	75	16	life	life	NOUN
bam-9610	75	17	expectancy	expectancy	NOUN
bam-9610	75	18	)	)	PUNCT
bam-9610	75	19	,	,	PUNCT
bam-9610	75	20	which	which	PRON
bam-9610	75	21	reflects	reflect	VERB
bam-9610	75	22	the	the	DET
bam-9610	75	23	expected	expect	VERB
bam-9610	75	24	healthy	healthy	ADJ
bam-9610	75	25	life	life	NOUN
bam-9610	75	26	expectancy	expectancy	NOUN
bam-9610	75	27	and	and	CCONJ
bam-9610	75	28	is	be	AUX
bam-9610	75	29	calculated	calculate	VERB
bam-9610	75	30	using	use	VERB
bam-9610	75	31	the	the	DET
bam-9610	75	32	sullivan	sullivan	PROPN
bam-9610	75	33	method.12	method.12	PROPN
bam-9610	75	34	hale	hale	PROPN
bam-9610	75	35	is	be	AUX
bam-9610	75	36	a	a	DET
bam-9610	75	37	single	single	ADJ
bam-9610	75	38	aggregate	aggregate	ADJ
bam-9610	75	39	indicator	indicator	NOUN
bam-9610	75	40	of	of	ADP
bam-9610	75	41	population	population	NOUN
bam-9610	75	42	health	health	NOUN
bam-9610	75	43	expressed	express	VERB
bam-9610	75	44	in	in	ADP
bam-9610	75	45	years	year	NOUN
bam-9610	75	46	lived	live	VERB
bam-9610	75	47	to	to	ADP
bam-9610	75	48	death	death	NOUN
bam-9610	75	49	without	without	ADP
bam-9610	75	50	disease	disease	NOUN
bam-9610	75	51	and	and	CCONJ
bam-9610	75	52	functional	functional	ADJ
bam-9610	75	53	limitations	limitation	NOUN
bam-9610	75	54	.	.	PUNCT
bam-9610	76	1	in	in	ADP
bam-9610	76	2	2016	2016	NUM
bam-9610	76	3	,	,	PUNCT
bam-9610	76	4	this	this	DET
bam-9610	76	5	indicator	indicator	NOUN
bam-9610	76	6	,	,	PUNCT
bam-9610	76	7	averaged	average	VERB
bam-9610	76	8	over	over	ADP
bam-9610	76	9	the	the	DET
bam-9610	76	10	world	world	NOUN
bam-9610	76	11	,	,	PUNCT
bam-9610	76	12	was	be	AUX
bam-9610	76	13	63.3	63.3	NUM
bam-9610	76	14	years.13	years.13	NOUN
bam-9610	76	15	it	it	PRON
bam-9610	76	16	is	be	AUX
bam-9610	76	17	the	the	DET
bam-9610	76	18	most	most	ADV
bam-9610	76	19	significant	significant	ADJ
bam-9610	76	20	for	for	ADP
bam-9610	76	21	assessing	assess	VERB
bam-9610	76	22	global	global	ADJ
bam-9610	76	23	human	human	ADJ
bam-9610	76	24	health	health	NOUN
bam-9610	76	25	.	.	PUNCT
bam-9610	77	1	together	together	ADV
bam-9610	77	2	,	,	PUNCT
bam-9610	77	3	the	the	DET
bam-9610	77	4	daly	daly	PROPN
bam-9610	77	5	and	and	CCONJ
bam-9610	77	6	hale	hale	PROPN
bam-9610	77	7	scores	score	NOUN
bam-9610	77	8	allow	allow	VERB
bam-9610	77	9	comparisons	comparison	NOUN
bam-9610	77	10	of	of	ADP
bam-9610	77	11	the	the	DET
bam-9610	77	12	extent	extent	NOUN
bam-9610	77	13	of	of	ADP
bam-9610	77	14	functional	functional	ADJ
bam-9610	77	15	health	health	NOUN
bam-9610	77	16	loss	loss	NOUN
bam-9610	77	17	due	due	ADP
bam-9610	77	18	to	to	ADP
bam-9610	77	19	illness	illness	NOUN
bam-9610	77	20	and	and	CCONJ
bam-9610	77	21	injury	injury	NOUN
bam-9610	77	22	across	across	ADP
bam-9610	77	23	countries	country	NOUN
bam-9610	77	24	and	and	CCONJ
bam-9610	77	25	across	across	ADP
bam-9610	77	26	different	different	ADJ
bam-9610	77	27	social	social	ADJ
bam-9610	77	28	groups	group	NOUN
bam-9610	77	29	.	.	PUNCT
bam-9610	78	1	they	they	PRON
bam-9610	78	2	can	can	AUX
bam-9610	78	3	be	be	AUX
bam-9610	78	4	used	use	VERB
bam-9610	78	5	to	to	PART
bam-9610	78	6	assess	assess	VERB
bam-9610	78	7	the	the	DET
bam-9610	78	8	effectiveness	effectiveness	NOUN
bam-9610	78	9	of	of	ADP
bam-9610	78	10	health	health	NOUN
bam-9610	78	11	systems	system	NOUN
bam-9610	78	12	and	and	CCONJ
bam-9610	78	13	understand	understand	VERB
bam-9610	78	14	the	the	DET
bam-9610	78	15	needs	need	NOUN
bam-9610	78	16	of	of	ADP
bam-9610	78	17	the	the	DET
bam-9610	78	18	population	population	NOUN
bam-9610	78	19	in	in	ADP
bam-9610	78	20	providing	provide	VERB
bam-9610	78	21	medical	medical	ADJ
bam-9610	78	22	care	care	NOUN
bam-9610	78	23	.	.	PUNCT
bam-9610	79	1	in	in	ADP
bam-9610	79	2	russia	russia	PROPN
bam-9610	79	3	for	for	ADP
bam-9610	79	4	2016	2016	NUM
bam-9610	79	5	the	the	DET
bam-9610	79	6	hale	hale	PROPN
bam-9610	79	7	indicator	indicator	NOUN
bam-9610	79	8	was	be	AUX
bam-9610	79	9	66.09	66.09	NUM
bam-9610	79	10	(	(	PUNCT
bam-9610	79	11	61.24	61.24	NUM
bam-9610	79	12	70.37	70.37	NUM
bam-9610	79	13	)	)	PUNCT
bam-9610	79	14	years	year	NOUN
bam-9610	79	15	for	for	ADP
bam-9610	79	16	women	woman	NOUN
bam-9610	79	17	and	and	CCONJ
bam-9610	79	18	57.78	57.78	NUM
bam-9610	79	19	(	(	PUNCT
bam-9610	79	20	53.22	53.22	NUM
bam-9610	79	21	62.52	62.52	NUM
bam-9610	79	22	)	)	PUNCT
bam-9610	79	23	years	year	NOUN
bam-9610	79	24	for	for	ADP
bam-9610	79	25	men	man	NOUN
bam-9610	79	26	,	,	PUNCT
bam-9610	79	27	which	which	PRON
bam-9610	79	28	is	be	AUX
bam-9610	79	29	on	on	ADP
bam-9610	79	30	average	average	ADJ
bam-9610	79	31	two	two	NUM
bam-9610	79	32	years	year	NOUN
bam-9610	79	33	more	more	ADJ
bam-9610	79	34	than	than	ADP
bam-9610	79	35	in	in	ADP
bam-9610	79	36	1990	1990	NUM
bam-9610	79	37	and	and	CCONJ
bam-9610	79	38	about	about	ADV
bam-9610	79	39	10	10	NUM
bam-9610	79	40	years	year	NOUN
bam-9610	79	41	less	less	ADJ
bam-9610	79	42	than	than	ADP
bam-9610	79	43	the	the	DET
bam-9610	79	44	average	average	ADJ
bam-9610	79	45	life	life	NOUN
bam-9610	79	46	expectancy	expectancy	NOUN
bam-9610	79	47	for	for	ADP
bam-9610	79	48	men	man	NOUN
bam-9610	79	49	and	and	CCONJ
bam-9610	79	50	women.14	women.14	PRON
bam-9610	79	51	global	global	ADJ
bam-9610	79	52	burden	burden	NOUN
bam-9610	79	53	of	of	ADP
bam-9610	79	54	orphan	orphan	NOUN
bam-9610	79	55	diseases	disease	NOUN
bam-9610	79	56	assessment	assessment	NOUN
bam-9610	79	57	estimating	estimate	VERB
bam-9610	79	58	the	the	DET
bam-9610	79	59	global	global	ADJ
bam-9610	79	60	burden	burden	NOUN
bam-9610	79	61	of	of	ADP
bam-9610	79	62	orphan	orphan	NOUN
bam-9610	79	63	diseases	disease	NOUN
bam-9610	79	64	is	be	AUX
bam-9610	79	65	challenging	challenge	VERB
bam-9610	79	66	.	.	PUNCT
bam-9610	80	1	the	the	DET
bam-9610	80	2	existing	exist	VERB
bam-9610	80	3	criteria	criterion	NOUN
bam-9610	80	4	for	for	ADP
bam-9610	80	5	assessing	assess	VERB
bam-9610	80	6	the	the	DET
bam-9610	80	7	global	global	ADJ
bam-9610	80	8	burden	burden	NOUN
bam-9610	80	9	of	of	ADP
bam-9610	80	10	disease	disease	NOUN
bam-9610	80	11	are	be	AUX
bam-9610	80	12	poorly	poorly	ADV
bam-9610	80	13	applicable	applicable	ADJ
bam-9610	80	14	to	to	ADP
bam-9610	80	15	rare	rare	ADJ
bam-9610	80	16	pathologies	pathology	NOUN
bam-9610	80	17	,	,	PUNCT
bam-9610	80	18	primarily	primarily	ADV
bam-9610	80	19	for	for	SCONJ
bam-9610	80	20	a	a	DET
bam-9610	80	21	number	number	NOUN
bam-9610	80	22	of	of	ADP
bam-9610	80	23	technical	technical	ADJ
bam-9610	80	24	reasons.13	reasons.13	PROPN
bam-9610	80	25	clearly	clearly	ADV
bam-9610	80	26	identify	identify	VERB
bam-9610	80	27	and	and	CCONJ
bam-9610	80	28	count	count	VERB
bam-9610	80	29	the	the	DET
bam-9610	80	30	rare	rare	ADJ
bam-9610	80	31	disease	disease	NOUN
bam-9610	80	32	is	be	AUX
bam-9610	80	33	a	a	DET
bam-9610	80	34	daunting	daunting	ADJ
bam-9610	80	35	task	task	NOUN
bam-9610	80	36	.	.	PUNCT
bam-9610	81	1	significant	significant	ADJ
bam-9610	81	2	difficulties	difficulty	NOUN
bam-9610	81	3	arise	arise	VERB
bam-9610	81	4	already	already	ADV
bam-9610	81	5	at	at	ADP
bam-9610	81	6	the	the	DET
bam-9610	81	7	stage	stage	NOUN
bam-9610	81	8	of	of	ADP
bam-9610	81	9	collecting	collect	VERB
bam-9610	81	10	statistical	statistical	ADJ
bam-9610	81	11	data	datum	NOUN
bam-9610	81	12	,	,	PUNCT
bam-9610	81	13	due	due	ADP
bam-9610	81	14	to	to	ADP
bam-9610	81	15	problems	problem	NOUN
bam-9610	81	16	with	with	ADP
bam-9610	81	17	the	the	DET
bam-9610	81	18	accuracy	accuracy	NOUN
bam-9610	81	19	of	of	ADP
bam-9610	81	20	the	the	DET
bam-9610	81	21	final	final	ADJ
bam-9610	81	22	diagnosis	diagnosis	NOUN
bam-9610	81	23	,	,	PUNCT
bam-9610	81	24	imperfections	imperfection	NOUN
bam-9610	81	25	in	in	ADP
bam-9610	81	26	registers	register	NOUN
bam-9610	81	27	and	and	CCONJ
bam-9610	81	28	reporting	reporting	NOUN
bam-9610	81	29	systems	system	NOUN
bam-9610	81	30	.	.	PUNCT
bam-9610	82	1	in	in	ADP
bam-9610	82	2	addition	addition	NOUN
bam-9610	82	3	,	,	PUNCT
bam-9610	82	4	different	different	ADJ
bam-9610	82	5	countries	country	NOUN
bam-9610	82	6	have	have	AUX
bam-9610	82	7	adopted	adopt	VERB
bam-9610	82	8	different	different	ADJ
bam-9610	82	9	definitions	definition	NOUN
bam-9610	82	10	of	of	ADP
bam-9610	82	11	a	a	DET
bam-9610	82	12	"	"	PUNCT
bam-9610	82	13	rare	rare	ADJ
bam-9610	82	14	disease	disease	NOUN
bam-9610	82	15	"	"	PUNCT
bam-9610	82	16	;	;	PUNCT
bam-9610	82	17	new	new	ADJ
bam-9610	82	18	conditions	condition	NOUN
bam-9610	82	19	are	be	AUX
bam-9610	82	20	detected	detect	VERB
bam-9610	82	21	every	every	DET
bam-9610	82	22	year	year	NOUN
bam-9610	82	23	,	,	PUNCT
bam-9610	82	24	which	which	PRON
bam-9610	82	25	add	add	VERB
bam-9610	82	26	to	to	ADP
bam-9610	82	27	the	the	DET
bam-9610	82	28	list	list	NOUN
bam-9610	82	29	,	,	PUNCT
bam-9610	82	30	while	while	SCONJ
bam-9610	82	31	others	other	NOUN
bam-9610	82	32	may	may	AUX
bam-9610	82	33	go	go	VERB
bam-9610	82	34	off	off	ADP
bam-9610	82	35	the	the	DET
bam-9610	82	36	list	list	NOUN
bam-9610	82	37	due	due	ADP
bam-9610	82	38	to	to	ADP
bam-9610	82	39	an	an	DET
bam-9610	82	40	increase	increase	NOUN
bam-9610	82	41	in	in	ADP
bam-9610	82	42	prevalence	prevalence	NOUN
bam-9610	82	43	.	.	PUNCT
bam-9610	83	1	thus	thus	ADV
bam-9610	83	2	,	,	PUNCT
bam-9610	83	3	due	due	ADP
bam-9610	83	4	to	to	ADP
bam-9610	83	5	the	the	DET
bam-9610	83	6	heterogeneity	heterogeneity	NOUN
bam-9610	83	7	of	of	ADP
bam-9610	83	8	the	the	DET
bam-9610	83	9	group	group	NOUN
bam-9610	83	10	of	of	ADP
bam-9610	83	11	orphan	orphan	NOUN
bam-9610	83	12	diseases	disease	NOUN
bam-9610	83	13	itself	itself	PRON
bam-9610	83	14	,	,	PUNCT
bam-9610	83	15	all	all	DET
bam-9610	83	16	epidemiological	epidemiological	ADJ
bam-9610	83	17	data	datum	NOUN
bam-9610	83	18	and	and	CCONJ
bam-9610	83	19	global	global	ADJ
bam-9610	83	20	estimates	estimate	NOUN
bam-9610	83	21	are	be	AUX
bam-9610	83	22	very	very	ADV
bam-9610	83	23	approximate.15	approximate.15	PROPN
bam-9610	83	24	the	the	DET
bam-9610	83	25	possibilities	possibility	NOUN
bam-9610	83	26	for	for	ADP
bam-9610	83	27	using	use	VERB
bam-9610	83	28	gbd	gbd	NOUN
bam-9610	83	29	metrics	metric	NOUN
bam-9610	83	30	are	be	AUX
bam-9610	83	31	quite	quite	ADV
bam-9610	83	32	narrow	narrow	ADJ
bam-9610	83	33	.	.	PUNCT
bam-9610	84	1	for	for	ADP
bam-9610	84	2	example	example	NOUN
bam-9610	84	3	,	,	PUNCT
bam-9610	84	4	the	the	DET
bam-9610	84	5	formulas	formula	NOUN
bam-9610	84	6	do	do	AUX
bam-9610	84	7	not	not	PART
bam-9610	84	8	take	take	VERB
bam-9610	84	9	into	into	ADP
bam-9610	84	10	account	account	NOUN
bam-9610	84	11	the	the	DET
bam-9610	84	12	stages	stage	NOUN
bam-9610	84	13	of	of	ADP
bam-9610	84	14	the	the	DET
bam-9610	84	15	disease	disease	NOUN
bam-9610	84	16	and	and	CCONJ
bam-9610	84	17	the	the	DET
bam-9610	84	18	long	long	ADJ
bam-9610	84	19	-	-	PUNCT
bam-9610	84	20	term	term	NOUN
bam-9610	84	21	prospects	prospect	NOUN
bam-9610	84	22	of	of	ADP
bam-9610	84	23	its	its	PRON
bam-9610	84	24	development	development	NOUN
bam-9610	84	25	,	,	PUNCT
bam-9610	84	26	do	do	AUX
bam-9610	84	27	not	not	PART
bam-9610	84	28	assess	assess	VERB
bam-9610	84	29	the	the	DET
bam-9610	84	30	economic	economic	ADJ
bam-9610	84	31	benefit	benefit	NOUN
bam-9610	84	32	that	that	PRON
bam-9610	84	33	can	can	AUX
bam-9610	84	34	be	be	AUX
bam-9610	84	35	obtained	obtain	VERB
bam-9610	84	36	through	through	ADP
bam-9610	84	37	early	early	ADJ
bam-9610	84	38	treatment	treatment	NOUN
bam-9610	84	39	,	,	PUNCT
bam-9610	84	40	which	which	PRON
bam-9610	84	41	will	will	AUX
bam-9610	84	42	exceed	exceed	VERB
bam-9610	84	43	(	(	PUNCT
bam-9610	84	44	for	for	ADP
bam-9610	84	45	example	example	NOUN
bam-9610	84	46	,	,	PUNCT
bam-9610	84	47	type	type	NOUN
bam-9610	84	48	1	1	NUM
bam-9610	84	49	gaucher	gaucher	PROPN
bam-9610	84	50	disease	disease	NOUN
bam-9610	84	51	)	)	PUNCT
bam-9610	84	52	expensive	expensive	ADJ
bam-9610	84	53	blood	blood	NOUN
bam-9610	84	54	transfusions	transfusion	NOUN
bam-9610	84	55	,	,	PUNCT
bam-9610	84	56	splenectomy	splenectomy	NOUN
bam-9610	84	57	,	,	PUNCT
bam-9610	84	58	pain	pain	NOUN
bam-9610	84	59	relief	relief	NOUN
bam-9610	84	60	,	,	PUNCT
bam-9610	84	61	hospitalizations	hospitalization	NOUN
bam-9610	84	62	,	,	PUNCT
bam-9610	84	63	endoprosthetics	endoprosthetic	NOUN
bam-9610	84	64	and	and	CCONJ
bam-9610	84	65	other	other	ADJ
bam-9610	84	66	operations	operation	NOUN
bam-9610	84	67	at	at	ADP
bam-9610	84	68	a	a	DET
bam-9610	84	69	later	later	ADJ
bam-9610	84	70	age	age	NOUN
bam-9610	84	71	.	.	PUNCT
bam-9610	85	1	while	while	SCONJ
bam-9610	85	2	these	these	DET
bam-9610	85	3	procedures	procedure	NOUN
bam-9610	85	4	themselves	themselves	PRON
bam-9610	85	5	are	be	AUX
bam-9610	85	6	considered	consider	VERB
bam-9610	85	7	costeffective	costeffective	ADJ
bam-9610	85	8	for	for	ADP
bam-9610	85	9	the	the	DET
bam-9610	85	10	untreated	untreated	ADJ
bam-9610	85	11	patient	patient	NOUN
bam-9610	85	12	,	,	PUNCT
bam-9610	85	13	they	they	PRON
bam-9610	85	14	can	can	AUX
bam-9610	85	15	be	be	AUX
bam-9610	85	16	very	very	ADV
bam-9610	85	17	costly	costly	ADJ
bam-9610	85	18	for	for	ADP
bam-9610	85	19	the	the	DET
bam-9610	85	20	healthcare	healthcare	PROPN
bam-9610	85	21	system.16	system.16	PROPN
bam-9610	85	22	splenectomy	splenectomy	NOUN
bam-9610	85	23	,	,	PUNCT
bam-9610	85	24	in	in	ADP
bam-9610	85	25	particular	particular	ADJ
bam-9610	85	26	,	,	PUNCT
bam-9610	85	27	impairs	impair	VERB
bam-9610	85	28	the	the	DET
bam-9610	85	29	long	long	ADJ
bam-9610	85	30	-	-	PUNCT
bam-9610	85	31	term	term	NOUN
bam-9610	85	32	perspective	perspective	NOUN
bam-9610	85	33	by	by	ADP
bam-9610	85	34	increasing	increase	VERB
bam-9610	85	35	the	the	DET
bam-9610	85	36	incidence	incidence	NOUN
bam-9610	85	37	of	of	ADP
bam-9610	85	38	disability	disability	NOUN
bam-9610	85	39	and	and	CCONJ
bam-9610	85	40	increasing	increase	VERB
bam-9610	85	41	the	the	DET
bam-9610	85	42	risk	risk	NOUN
bam-9610	85	43	of	of	ADP
bam-9610	85	44	osteonecrosis.17	osteonecrosis.17	NOUN
bam-9610	85	45	gbd	gbd	NOUN
bam-9610	85	46	metrics	metric	NOUN
bam-9610	85	47	ignore	ignore	VERB
bam-9610	85	48	the	the	DET
bam-9610	85	49	economic	economic	ADJ
bam-9610	85	50	benefits	benefit	NOUN
bam-9610	85	51	of	of	ADP
bam-9610	85	52	early	early	ADJ
bam-9610	85	53	,	,	PUNCT
bam-9610	85	54	effective	effective	ADJ
bam-9610	85	55	treatment	treatment	NOUN
bam-9610	85	56	that	that	PRON
bam-9610	85	57	allows	allow	VERB
bam-9610	85	58	the	the	DET
bam-9610	85	59	patient	patient	NOUN
bam-9610	85	60	and	and	CCONJ
bam-9610	85	61	family	family	NOUN
bam-9610	85	62	to	to	PART
bam-9610	85	63	participate	participate	VERB
bam-9610	85	64	in	in	ADP
bam-9610	85	65	working	work	VERB
bam-9610	85	66	life	life	NOUN
bam-9610	85	67	.	.	PUNCT
bam-9610	86	1	as	as	SCONJ
bam-9610	86	2	calculated	calculate	VERB
bam-9610	86	3	by	by	ADP
bam-9610	86	4	dr	dr	PROPN
bam-9610	86	5	.	.	PROPN
bam-9610	86	6	hyru	hyru	PROPN
bam-9610	86	7	and	and	CCONJ
bam-9610	86	8	colleagues,17	colleagues,17	NOUN
bam-9610	86	9	a	a	DET
bam-9610	86	10	young	young	ADJ
bam-9610	86	11	married	married	ADJ
bam-9610	86	12	specialist	specialist	NOUN
bam-9610	86	13	with	with	ADP
bam-9610	86	14	a	a	DET
bam-9610	86	15	diagnosis	diagnosis	NOUN
bam-9610	86	16	of	of	ADP
bam-9610	86	17	type	type	NOUN
bam-9610	86	18	1	1	NUM
bam-9610	86	19	gaucher	gaucher	PROPN
bam-9610	86	20	disease	disease	NOUN
bam-9610	86	21	,	,	PUNCT
bam-9610	86	22	who	who	PRON
bam-9610	86	23	is	be	AUX
bam-9610	86	24	in	in	ADP
bam-9610	86	25	his	his	PRON
bam-9610	86	26	twenties	twenty	NOUN
bam-9610	86	27	,	,	PUNCT
bam-9610	86	28	undergoing	undergo	VERB
bam-9610	86	29	enzyme	enzyme	NOUN
bam-9610	86	30	replacement	replacement	NOUN
bam-9610	86	31	therapy	therapy	NOUN
bam-9610	86	32	,	,	PUNCT
bam-9610	86	33	together	together	ADV
bam-9610	86	34	with	with	ADP
bam-9610	86	35	his	his	PRON
bam-9610	86	36	wife	wife	NOUN
bam-9610	86	37	,	,	PUNCT
bam-9610	86	38	will	will	AUX
bam-9610	86	39	bring	bring	VERB
bam-9610	86	40	about	about	ADV
bam-9610	86	41	100000	100000	NUM
bam-9610	86	42	british	british	ADJ
bam-9610	86	43	pounds	pound	NOUN
bam-9610	86	44	a	a	DET
bam-9610	86	45	year	year	NOUN
bam-9610	86	46	to	to	ADP
bam-9610	86	47	the	the	DET
bam-9610	86	48	state	state	NOUN
bam-9610	86	49	in	in	ADP
bam-9610	86	50	tax	tax	NOUN
bam-9610	86	51	payments	payment	NOUN
bam-9610	86	52	,	,	PUNCT
bam-9610	86	53	which	which	PRON
bam-9610	86	54	will	will	AUX
bam-9610	86	55	fully	fully	ADV
bam-9610	86	56	cover	cover	VERB
bam-9610	86	57	the	the	DET
bam-9610	86	58	cost	cost	NOUN
bam-9610	86	59	of	of	ADP
bam-9610	86	60	the	the	DET
bam-9610	86	61	medicine	medicine	NOUN
bam-9610	86	62	.	.	PUNCT
bam-9610	87	1	thus	thus	ADV
bam-9610	87	2	,	,	PUNCT
bam-9610	87	3	we	we	PRON
bam-9610	87	4	would	would	AUX
bam-9610	87	5	like	like	VERB
bam-9610	87	6	to	to	PART
bam-9610	87	7	emphasize	emphasize	VERB
bam-9610	87	8	not	not	PART
bam-9610	87	9	only	only	ADV
bam-9610	87	10	the	the	DET
bam-9610	87	11	ethical	ethical	ADJ
bam-9610	87	12	underpinnings	underpinning	NOUN
bam-9610	87	13	of	of	ADP
bam-9610	87	14	effective	effective	ADJ
bam-9610	87	15	treatment	treatment	NOUN
bam-9610	87	16	,	,	PUNCT
bam-9610	87	17	but	but	CCONJ
bam-9610	87	18	also	also	ADV
bam-9610	87	19	the	the	DET
bam-9610	87	20	savings	saving	NOUN
bam-9610	87	21	that	that	PRON
bam-9610	87	22	healthcare	healthcare	PROPN
bam-9610	87	23	can	can	AUX
bam-9610	87	24	receive	receive	VERB
bam-9610	87	25	.	.	PUNCT
bam-9610	88	1	ethical	ethical	ADJ
bam-9610	88	2	issue	issue	NOUN
bam-9610	88	3	of	of	ADP
bam-9610	88	4	application	application	NOUN
bam-9610	88	5	of	of	ADP
bam-9610	88	6	global	global	ADJ
bam-9610	88	7	burden	burden	NOUN
bam-9610	88	8	of	of	ADP
bam-9610	88	9	disease	disease	NOUN
bam-9610	88	10	metrics	metric	NOUN
bam-9610	88	11	in	in	ADP
bam-9610	88	12	patients	patient	NOUN
bam-9610	88	13	with	with	ADP
bam-9610	88	14	orphan	orphan	NOUN
bam-9610	88	15	pathology	pathology	NOUN
bam-9610	88	16	speaking	speak	VERB
bam-9610	88	17	of	of	ADP
bam-9610	88	18	rare	rare	ADJ
bam-9610	88	19	diseases	disease	NOUN
bam-9610	88	20	,	,	PUNCT
bam-9610	88	21	it	it	PRON
bam-9610	88	22	is	be	AUX
bam-9610	88	23	difficult	difficult	ADJ
bam-9610	88	24	to	to	PART
bam-9610	88	25	use	use	VERB
bam-9610	88	26	standard	standard	ADJ
bam-9610	88	27	metrics	metric	NOUN
bam-9610	88	28	for	for	ADP
bam-9610	88	29	assessing	assess	VERB
bam-9610	88	30	gbd	gbd	NOUN
bam-9610	88	31	for	for	ADP
bam-9610	88	32	a	a	DET
bam-9610	88	33	number	number	NOUN
bam-9610	88	34	of	of	ADP
bam-9610	88	35	ethical	ethical	ADJ
bam-9610	88	36	reasons	reason	NOUN
bam-9610	88	37	,	,	PUNCT
bam-9610	88	38	as	as	SCONJ
bam-9610	88	39	it	it	PRON
bam-9610	88	40	forces	force	VERB
bam-9610	88	41	one	one	PRON
bam-9610	88	42	to	to	PART
bam-9610	88	43	think	think	VERB
bam-9610	88	44	in	in	ADP
bam-9610	88	45	accordance	accordance	NOUN
bam-9610	88	46	with	with	ADP
bam-9610	88	47	a	a	DET
bam-9610	88	48	utilitarian	utilitarian	ADJ
bam-9610	88	49	approach	approach	NOUN
bam-9610	88	50	and	and	CCONJ
bam-9610	88	51	puts	put	VERB
bam-9610	88	52	financial	financial	ADJ
bam-9610	88	53	benefits	benefit	NOUN
bam-9610	88	54	as	as	ADP
bam-9610	88	55	its	its	PRON
bam-9610	88	56	goal	goal	NOUN
bam-9610	88	57	,	,	PUNCT
bam-9610	88	58	which	which	PRON
bam-9610	88	59	inevitably	inevitably	ADV
bam-9610	88	60	pushes	push	VERB
bam-9610	88	61	the	the	DET
bam-9610	88	62	value	value	NOUN
bam-9610	88	63	of	of	ADP
bam-9610	88	64	human	human	ADJ
bam-9610	88	65	life	life	NOUN
bam-9610	88	66	and	and	CCONJ
bam-9610	88	67	its	its	PRON
bam-9610	88	68	quality	quality	NOUN
bam-9610	88	69	to	to	ADP
bam-9610	88	70	second	second	ADJ
bam-9610	88	71	place	place	NOUN
bam-9610	88	72	.	.	PUNCT
bam-9610	89	1	according	accord	VERB
bam-9610	89	2	to	to	ADP
bam-9610	89	3	british	british	ADJ
bam-9610	89	4	researchers	researcher	NOUN
bam-9610	89	5	,	,	PUNCT
bam-9610	89	6	for	for	ADP
bam-9610	89	7	example	example	NOUN
bam-9610	89	8	,	,	PUNCT
bam-9610	89	9	the	the	DET
bam-9610	89	10	cost	cost	NOUN
bam-9610	89	11	of	of	ADP
bam-9610	89	12	15	15	NUM
bam-9610	89	13	years	year	NOUN
bam-9610	89	14	of	of	ADP
bam-9610	89	15	therapy	therapy	NOUN
bam-9610	89	16	for	for	ADP
bam-9610	89	17	one	one	NUM
bam-9610	89	18	evaluation	evaluation	NOUN
bam-9610	89	19	of	of	ADP
bam-9610	89	20	orphan	orphan	NOUN
bam-9610	89	21	diseases	disease	NOUN
bam-9610	89	22	global	global	ADJ
bam-9610	89	23	burden	burden	PROPN
bam-9610	89	24	eur	eur	PROPN
bam-9610	89	25	j	j	PROPN
bam-9610	89	26	transl	transl	PROPN
bam-9610	89	27	myol	myol	NOUN
bam-9610	89	28	2021	2021	NUM
bam-9610	89	29	;	;	PUNCT
bam-9610	89	30	31	31	NUM
bam-9610	89	31	(	(	PUNCT
bam-9610	89	32	2	2	NUM
bam-9610	89	33	):	):	PUNCT
bam-9610	89	34	9610	9610	NUM
bam-9610	89	35	.	.	PUNCT
bam-9610	90	1	doi	doi	NOUN
bam-9610	90	2	:	:	PUNCT
bam-9610	90	3	10.4081	10.4081	NUM
bam-9610	90	4	/	/	SYM
bam-9610	90	5	ejtm.2021.9610	ejtm.2021.9610	NUM
bam-9610	90	6	6	6	NUM
bam-9610	90	7	patient	patient	NOUN
bam-9610	90	8	with	with	ADP
bam-9610	90	9	pompe	pompe	PROPN
bam-9610	90	10	disease	disease	NOUN
bam-9610	90	11	2500000	2500000	NUM
bam-9610	90	12	british	british	ADJ
bam-9610	90	13	pounds	pound	NOUN
bam-9610	90	14	(	(	PUNCT
bam-9610	90	15	3460337	3460337	NUM
bam-9610	90	16	usd	usd	NOUN
bam-9610	90	17	)	)	PUNCT
bam-9610	90	18	is	be	AUX
bam-9610	90	19	equal	equal	ADJ
bam-9610	90	20	to	to	ADP
bam-9610	90	21	the	the	DET
bam-9610	90	22	cost	cost	NOUN
bam-9610	90	23	of	of	ADP
bam-9610	90	24	520	520	NUM
bam-9610	90	25	arthroplasty	arthroplasty	NOUN
bam-9610	90	26	surgeries	surgery	NOUN
bam-9610	90	27	,	,	PUNCT
bam-9610	90	28	which	which	PRON
bam-9610	90	29	implies	imply	VERB
bam-9610	90	30	a	a	DET
bam-9610	90	31	greater	great	ADJ
bam-9610	90	32	benefit	benefit	NOUN
bam-9610	90	33	in	in	ADP
bam-9610	90	34	the	the	DET
bam-9610	90	35	treatment	treatment	NOUN
bam-9610	90	36	of	of	ADP
bam-9610	90	37	complications	complication	NOUN
bam-9610	90	38	of	of	ADP
bam-9610	90	39	the	the	DET
bam-9610	90	40	disease	disease	NOUN
bam-9610	90	41	,	,	PUNCT
bam-9610	90	42	in	in	ADP
bam-9610	90	43	comparison	comparison	NOUN
bam-9610	90	44	with	with	ADP
bam-9610	90	45	the	the	DET
bam-9610	90	46	appointment	appointment	NOUN
bam-9610	90	47	of	of	ADP
bam-9610	90	48	pathogenetic	pathogenetic	ADJ
bam-9610	90	49	therapy	therapy	NOUN
bam-9610	90	50	.	.	PUNCT
bam-9610	91	1	the	the	DET
bam-9610	91	2	daly	daly	PROPN
bam-9610	91	3	and	and	CCONJ
bam-9610	91	4	qaly	qaly	NOUN
bam-9610	91	5	metrics	metric	NOUN
bam-9610	91	6	do	do	AUX
bam-9610	91	7	not	not	PART
bam-9610	91	8	take	take	VERB
bam-9610	91	9	into	into	ADP
bam-9610	91	10	account	account	NOUN
bam-9610	91	11	the	the	DET
bam-9610	91	12	relative	relative	ADJ
bam-9610	91	13	safety	safety	NOUN
bam-9610	91	14	of	of	ADP
bam-9610	91	15	treatment	treatment	NOUN
bam-9610	91	16	:	:	PUNCT
bam-9610	91	17	for	for	ADP
bam-9610	91	18	example	example	NOUN
bam-9610	91	19	,	,	PUNCT
bam-9610	91	20	a	a	DET
bam-9610	91	21	qaly	qaly	NOUN
bam-9610	91	22	analysis	analysis	NOUN
bam-9610	91	23	will	will	AUX
bam-9610	91	24	help	help	VERB
bam-9610	91	25	guide	guide	VERB
bam-9610	91	26	the	the	DET
bam-9610	91	27	choice	choice	NOUN
bam-9610	91	28	of	of	ADP
bam-9610	91	29	bone	bone	NOUN
bam-9610	91	30	marrow	marrow	NOUN
bam-9610	91	31	transplantation	transplantation	NOUN
bam-9610	91	32	in	in	ADP
bam-9610	91	33	gaucher	gaucher	PROPN
bam-9610	91	34	disease	disease	NOUN
bam-9610	91	35	,	,	PUNCT
bam-9610	91	36	but	but	CCONJ
bam-9610	91	37	this	this	DET
bam-9610	91	38	manipulation	manipulation	NOUN
bam-9610	91	39	can	can	AUX
bam-9610	91	40	be	be	AUX
bam-9610	91	41	fatal	fatal	ADJ
bam-9610	91	42	when	when	SCONJ
bam-9610	91	43	compared	compare	VERB
bam-9610	91	44	to	to	ADP
bam-9610	91	45	safe	safe	ADJ
bam-9610	91	46	and	and	CCONJ
bam-9610	91	47	effective	effective	ADJ
bam-9610	91	48	enzyme	enzyme	NOUN
bam-9610	91	49	infusions	infusion	NOUN
bam-9610	91	50	.	.	PUNCT
bam-9610	92	1	based	base	VERB
bam-9610	92	2	on	on	ADP
bam-9610	92	3	the	the	DET
bam-9610	92	4	cost	cost	NOUN
bam-9610	92	5	of	of	ADP
bam-9610	92	6	qalys	qaly	NOUN
bam-9610	92	7	,	,	PUNCT
bam-9610	92	8	nice	nice	ADJ
bam-9610	92	9	would	would	AUX
bam-9610	92	10	have	have	VERB
bam-9610	92	11	to	to	PART
bam-9610	92	12	choose	choose	VERB
bam-9610	92	13	risky	risky	ADJ
bam-9610	92	14	bone	bone	NOUN
bam-9610	92	15	marrow	marrow	NOUN
bam-9610	92	16	transplant	transplant	NOUN
bam-9610	92	17	over	over	ADP
bam-9610	92	18	specific	specific	ADJ
bam-9610	92	19	therapy	therapy	NOUN
bam-9610	92	20	for	for	ADP
bam-9610	92	21	gaucher	gaucher	PROPN
bam-9610	92	22	disease	disease	NOUN
bam-9610	92	23	(	(	PUNCT
bam-9610	92	24	costing	cost	VERB
bam-9610	92	25	between	between	ADP
bam-9610	92	26	380000	380000	NUM
bam-9610	92	27	british	british	ADJ
bam-9610	92	28	pounds	pound	NOUN
bam-9610	92	29	and	and	CCONJ
bam-9610	92	30	476	476	NUM
bam-9610	92	31	000	000	NUM
bam-9610	92	32	british	british	ADJ
bam-9610	92	33	pounds	pound	NOUN
bam-9610	92	34	(	(	PUNCT
bam-9610	92	35	525971	525971	NUM
bam-9610	92	36	usd	usd	NOUN
bam-9610	92	37	and	and	CCONJ
bam-9610	92	38	658848	658848	NUM
bam-9610	92	39	usd	usd	NOUN
bam-9610	92	40	)	)	PUNCT
bam-9610	92	41	per	per	ADP
bam-9610	92	42	qaly	qaly	NOUN
bam-9610	92	43	,	,	PUNCT
bam-9610	92	44	depending	depend	VERB
bam-9610	92	45	on	on	ADP
bam-9610	92	46	genotype	genotype	NOUN
bam-9610	92	47	)	)	PUNCT
bam-9610	92	48	.	.	PUNCT
bam-9610	93	1	however	however	ADV
bam-9610	93	2	,	,	PUNCT
bam-9610	93	3	nice	nice	ADJ
bam-9610	93	4	recommended	recommend	VERB
bam-9610	93	5	the	the	DET
bam-9610	93	6	latter	latter	ADJ
bam-9610	93	7	,	,	PUNCT
bam-9610	93	8	abandoning	abandon	VERB
bam-9610	93	9	the	the	DET
bam-9610	93	10	costeffective	costeffective	ADJ
bam-9610	93	11	approach	approach	NOUN
bam-9610	93	12	.	.	PUNCT
bam-9610	94	1	a	a	DET
bam-9610	94	2	significant	significant	ADJ
bam-9610	94	3	difficulty	difficulty	NOUN
bam-9610	94	4	in	in	ADP
bam-9610	94	5	the	the	DET
bam-9610	94	6	case	case	NOUN
bam-9610	94	7	of	of	ADP
bam-9610	94	8	rare	rare	ADJ
bam-9610	94	9	pathologies	pathology	NOUN
bam-9610	94	10	is	be	AUX
bam-9610	94	11	that	that	SCONJ
bam-9610	94	12	gbd	gbd	NOUN
bam-9610	94	13	metrics	metric	NOUN
bam-9610	94	14	are	be	AUX
bam-9610	94	15	typically	typically	ADV
bam-9610	94	16	used	use	VERB
bam-9610	94	17	for	for	ADP
bam-9610	94	18	comparative	comparative	ADJ
bam-9610	94	19	economic	economic	ADJ
bam-9610	94	20	assessments	assessment	NOUN
bam-9610	94	21	of	of	ADP
bam-9610	94	22	different	different	ADJ
bam-9610	94	23	medical	medical	ADJ
bam-9610	94	24	intervention	intervention	NOUN
bam-9610	94	25	options	option	NOUN
bam-9610	94	26	.	.	PUNCT
bam-9610	95	1	but	but	CCONJ
bam-9610	95	2	many	many	ADJ
bam-9610	95	3	orphan	orphan	NOUN
bam-9610	95	4	diseases	disease	NOUN
bam-9610	95	5	have	have	VERB
bam-9610	95	6	a	a	DET
bam-9610	95	7	single	single	ADJ
bam-9610	95	8	drug	drug	NOUN
bam-9610	95	9	for	for	ADP
bam-9610	95	10	specific	specific	ADJ
bam-9610	95	11	therapy	therapy	NOUN
bam-9610	95	12	,	,	PUNCT
bam-9610	95	13	or	or	CCONJ
bam-9610	95	14	are	be	AUX
bam-9610	95	15	treated	treat	VERB
bam-9610	95	16	exclusively	exclusively	ADV
bam-9610	95	17	symptomatically	symptomatically	ADV
bam-9610	95	18	.	.	PUNCT
bam-9610	96	1	thus	thus	ADV
bam-9610	96	2	,	,	PUNCT
bam-9610	96	3	it	it	PRON
bam-9610	96	4	is	be	AUX
bam-9610	96	5	not	not	PART
bam-9610	96	6	correct	correct	ADJ
bam-9610	96	7	to	to	PART
bam-9610	96	8	assess	assess	VERB
bam-9610	96	9	the	the	DET
bam-9610	96	10	benefits	benefit	NOUN
bam-9610	96	11	of	of	ADP
bam-9610	96	12	the	the	DET
bam-9610	96	13	only	only	ADJ
bam-9610	96	14	option	option	NOUN
bam-9610	96	15	for	for	ADP
bam-9610	96	16	medical	medical	ADJ
bam-9610	96	17	care	care	NOUN
bam-9610	96	18	.	.	PUNCT
bam-9610	97	1	gbd	gbd	NOUN
bam-9610	97	2	-	-	PUNCT
bam-9610	97	3	based	base	VERB
bam-9610	97	4	economic	economic	ADJ
bam-9610	97	5	models	model	NOUN
bam-9610	97	6	are	be	AUX
bam-9610	97	7	not	not	PART
bam-9610	97	8	transparent	transparent	ADJ
bam-9610	97	9	enough	enough	ADV
bam-9610	97	10	and	and	CCONJ
bam-9610	97	11	are	be	AUX
bam-9610	97	12	often	often	ADV
bam-9610	97	13	used	use	VERB
bam-9610	97	14	in	in	ADP
bam-9610	97	15	a	a	DET
bam-9610	97	16	discriminatory	discriminatory	ADJ
bam-9610	97	17	manner	manner	NOUN
bam-9610	97	18	in	in	ADP
bam-9610	97	19	terms	term	NOUN
bam-9610	97	20	of	of	ADP
bam-9610	97	21	age	age	NOUN
bam-9610	97	22	,	,	PUNCT
bam-9610	97	23	favoring	favor	VERB
bam-9610	97	24	young	young	ADJ
bam-9610	97	25	people	people	NOUN
bam-9610	97	26	who	who	PRON
bam-9610	97	27	can	can	AUX
bam-9610	97	28	live	live	VERB
bam-9610	97	29	longer	long	ADV
bam-9610	97	30	and	and	CCONJ
bam-9610	97	31	have	have	VERB
bam-9610	97	32	greater	great	ADJ
bam-9610	97	33	capacity	capacity	NOUN
bam-9610	97	34	to	to	PART
bam-9610	97	35	act	act	VERB
bam-9610	97	36	,	,	PUNCT
bam-9610	97	37	while	while	SCONJ
bam-9610	97	38	giving	give	VERB
bam-9610	97	39	less	less	ADJ
bam-9610	97	40	value	value	NOUN
bam-9610	97	41	to	to	ADP
bam-9610	97	42	the	the	DET
bam-9610	97	43	lives	life	NOUN
bam-9610	97	44	of	of	ADP
bam-9610	97	45	children	child	NOUN
bam-9610	97	46	and	and	CCONJ
bam-9610	97	47	the	the	DET
bam-9610	97	48	elderly	elderly	ADJ
bam-9610	97	49	.	.	PUNCT
bam-9610	98	1	this	this	PRON
bam-9610	98	2	is	be	AUX
bam-9610	98	3	typical	typical	ADJ
bam-9610	98	4	for	for	ADP
bam-9610	98	5	the	the	DET
bam-9610	98	6	daly	daly	NOUN
bam-9610	98	7	and	and	CCONJ
bam-9610	98	8	qaly	qaly	PROPN
bam-9610	98	9	.	.	PUNCT
bam-9610	99	1	the	the	DET
bam-9610	99	2	who	who	PRON
bam-9610	99	3	working	working	NOUN
bam-9610	99	4	group	group	NOUN
bam-9610	99	5	recognizes	recognize	VERB
bam-9610	99	6	that	that	SCONJ
bam-9610	99	7	its	its	PRON
bam-9610	99	8	matrix	matrix	NOUN
bam-9610	99	9	also	also	ADV
bam-9610	99	10	requires	require	VERB
bam-9610	99	11	significant	significant	ADJ
bam-9610	99	12	refinement	refinement	NOUN
bam-9610	99	13	.	.	PUNCT
bam-9610	100	1	for	for	ADP
bam-9610	100	2	these	these	DET
bam-9610	100	3	reasons	reason	NOUN
bam-9610	100	4	,	,	PUNCT
bam-9610	100	5	law	law	NOUN
bam-9610	100	6	from	from	ADP
bam-9610	100	7	using	use	VERB
bam-9610	100	8	cost	cost	NOUN
bam-9610	100	9	-	-	PUNCT
bam-9610	100	10	benefit	benefit	NOUN
bam-9610	100	11	analysis	analysis	NOUN
bam-9610	100	12	to	to	PART
bam-9610	100	13	make	make	VERB
bam-9610	100	14	treatment	treatment	NOUN
bam-9610	100	15	decisions	decision	NOUN
bam-9610	100	16	prohibits	prohibit	VERB
bam-9610	100	17	insurance	insurance	NOUN
bam-9610	100	18	companies	company	NOUN
bam-9610	100	19	in	in	ADP
bam-9610	100	20	the	the	DET
bam-9610	100	21	united	united	PROPN
bam-9610	100	22	states	states	PROPN
bam-9610	100	23	.	.	PUNCT
bam-9610	101	1	the	the	DET
bam-9610	101	2	idea	idea	NOUN
bam-9610	101	3	of	of	ADP
bam-9610	101	4	the	the	DET
bam-9610	101	5	high	high	ADJ
bam-9610	101	6	cost	cost	NOUN
bam-9610	101	7	of	of	ADP
bam-9610	101	8	treating	treat	VERB
bam-9610	101	9	orphan	orphan	NOUN
bam-9610	101	10	diseases	disease	NOUN
bam-9610	101	11	also	also	ADV
bam-9610	101	12	may	may	AUX
bam-9610	101	13	not	not	PART
bam-9610	101	14	always	always	ADV
bam-9610	101	15	correspond	correspond	VERB
bam-9610	101	16	to	to	ADP
bam-9610	101	17	reality	reality	NOUN
bam-9610	101	18	,	,	PUNCT
bam-9610	101	19	since	since	SCONJ
bam-9610	101	20	over	over	ADP
bam-9610	101	21	time	time	NOUN
bam-9610	101	22	and	and	CCONJ
bam-9610	101	23	with	with	ADP
bam-9610	101	24	the	the	DET
bam-9610	101	25	development	development	NOUN
bam-9610	101	26	of	of	ADP
bam-9610	101	27	technology	technology	NOUN
bam-9610	101	28	,	,	PUNCT
bam-9610	101	29	the	the	DET
bam-9610	101	30	price	price	NOUN
bam-9610	101	31	can	can	AUX
bam-9610	101	32	change	change	VERB
bam-9610	101	33	.	.	PUNCT
bam-9610	102	1	medicine	medicine	NOUN
bam-9610	102	2	does	do	AUX
bam-9610	102	3	not	not	PART
bam-9610	102	4	refuse	refuse	VERB
bam-9610	102	5	transplant	transplant	NOUN
bam-9610	102	6	operations	operation	NOUN
bam-9610	102	7	for	for	ADP
bam-9610	102	8	reasons	reason	NOUN
bam-9610	102	9	of	of	ADP
bam-9610	102	10	economic	economic	ADJ
bam-9610	102	11	efficiency	efficiency	NOUN
bam-9610	102	12	,	,	PUNCT
bam-9610	102	13	although	although	SCONJ
bam-9610	102	14	recipients	recipient	NOUN
bam-9610	102	15	have	have	VERB
bam-9610	102	16	a	a	DET
bam-9610	102	17	shorter	short	ADJ
bam-9610	102	18	life	life	NOUN
bam-9610	102	19	expectancy	expectancy	NOUN
bam-9610	102	20	and	and	CCONJ
bam-9610	102	21	high	high	ADJ
bam-9610	102	22	costs	cost	NOUN
bam-9610	102	23	for	for	ADP
bam-9610	102	24	a	a	DET
bam-9610	102	25	course	course	NOUN
bam-9610	102	26	of	of	ADP
bam-9610	102	27	immunosuppressive	immunosuppressive	ADJ
bam-9610	102	28	drugs	drug	NOUN
bam-9610	102	29	and	and	CCONJ
bam-9610	102	30	treatment	treatment	NOUN
bam-9610	102	31	of	of	ADP
bam-9610	102	32	complications	complication	NOUN
bam-9610	102	33	.	.	PUNCT
bam-9610	103	1	when	when	SCONJ
bam-9610	103	2	transplantation	transplantation	NOUN
bam-9610	103	3	only	only	ADV
bam-9610	103	4	began	begin	VERB
bam-9610	103	5	to	to	PART
bam-9610	103	6	enter	enter	VERB
bam-9610	103	7	clinical	clinical	ADJ
bam-9610	103	8	practice	practice	NOUN
bam-9610	103	9	,	,	PUNCT
bam-9610	103	10	this	this	DET
bam-9610	103	11	method	method	NOUN
bam-9610	103	12	was	be	AUX
bam-9610	103	13	negatively	negatively	ADV
bam-9610	103	14	assessed	assess	VERB
bam-9610	103	15	as	as	ADP
bam-9610	103	16	radical	radical	ADJ
bam-9610	103	17	and	and	CCONJ
bam-9610	103	18	expensive	expensive	ADJ
bam-9610	103	19	,	,	PUNCT
bam-9610	103	20	but	but	CCONJ
bam-9610	103	21	now	now	ADV
bam-9610	103	22	it	it	PRON
bam-9610	103	23	is	be	AUX
bam-9610	103	24	the	the	DET
bam-9610	103	25	standard	standard	ADJ
bam-9610	103	26	widespread	widespread	ADJ
bam-9610	103	27	treatment	treatment	NOUN
bam-9610	103	28	option	option	NOUN
bam-9610	103	29	.	.	PUNCT
bam-9610	104	1	assessing	assess	VERB
bam-9610	104	2	the	the	DET
bam-9610	104	3	quality	quality	NOUN
bam-9610	104	4	of	of	ADP
bam-9610	104	5	life	life	NOUN
bam-9610	104	6	and	and	CCONJ
bam-9610	104	7	standardizing	standardize	VERB
bam-9610	104	8	this	this	DET
bam-9610	104	9	parameter	parameter	NOUN
bam-9610	104	10	is	be	AUX
bam-9610	104	11	convenient	convenient	ADJ
bam-9610	104	12	,	,	PUNCT
bam-9610	104	13	but	but	CCONJ
bam-9610	104	14	one	one	NUM
bam-9610	104	15	person	person	NOUN
bam-9610	104	16	is	be	AUX
bam-9610	104	17	not	not	PART
bam-9610	104	18	able	able	ADJ
bam-9610	104	19	to	to	PART
bam-9610	104	20	estimate	estimate	VERB
bam-9610	104	21	the	the	DET
bam-9610	104	22	quality	quality	NOUN
bam-9610	104	23	of	of	ADP
bam-9610	104	24	life	life	NOUN
bam-9610	104	25	of	of	ADP
bam-9610	104	26	another	another	DET
bam-9610	104	27	person	person	NOUN
bam-9610	104	28	accurately	accurately	ADV
bam-9610	104	29	.	.	PUNCT
bam-9610	105	1	people	people	NOUN
bam-9610	105	2	do	do	AUX
bam-9610	105	3	not	not	PART
bam-9610	105	4	understand	understand	VERB
bam-9610	105	5	well	well	INTJ
bam-9610	105	6	the	the	DET
bam-9610	105	7	quality	quality	NOUN
bam-9610	105	8	of	of	ADP
bam-9610	105	9	life	life	NOUN
bam-9610	105	10	of	of	ADP
bam-9610	105	11	others	other	NOUN
bam-9610	105	12	.	.	PUNCT
bam-9610	106	1	thus	thus	ADV
bam-9610	106	2	,	,	PUNCT
bam-9610	106	3	the	the	DET
bam-9610	106	4	expression	expression	NOUN
bam-9610	106	5	of	of	ADP
bam-9610	106	6	the	the	DET
bam-9610	106	7	quantity	quantity	NOUN
bam-9610	106	8	and	and	CCONJ
bam-9610	106	9	quality	quality	NOUN
bam-9610	106	10	of	of	ADP
bam-9610	106	11	human	human	ADJ
bam-9610	106	12	life	life	NOUN
bam-9610	106	13	in	in	ADP
bam-9610	106	14	economic	economic	ADJ
bam-9610	106	15	units	unit	NOUN
bam-9610	106	16	sets	set	VERB
bam-9610	106	17	the	the	DET
bam-9610	106	18	price	price	NOUN
bam-9610	106	19	for	for	ADP
bam-9610	106	20	human	human	ADJ
bam-9610	106	21	life	life	NOUN
bam-9610	106	22	,	,	PUNCT
bam-9610	106	23	belittles	belittle	VERB
bam-9610	106	24	their	their	PRON
bam-9610	106	25	individuality	individuality	NOUN
bam-9610	106	26	and	and	CCONJ
bam-9610	106	27	objectifies	objectify	VERB
bam-9610	106	28	people	people	NOUN
bam-9610	106	29	.	.	PUNCT
bam-9610	107	1	therefore	therefore	ADV
bam-9610	107	2	,	,	PUNCT
bam-9610	107	3	the	the	DET
bam-9610	107	4	utilitarian	utilitarian	ADJ
bam-9610	107	5	approach	approach	NOUN
bam-9610	107	6	should	should	AUX
bam-9610	107	7	not	not	PART
bam-9610	107	8	be	be	AUX
bam-9610	107	9	applied	apply	VERB
bam-9610	107	10	to	to	ADP
bam-9610	107	11	people	people	NOUN
bam-9610	107	12	,	,	PUNCT
bam-9610	107	13	since	since	SCONJ
bam-9610	107	14	it	it	PRON
bam-9610	107	15	levels	level	VERB
bam-9610	107	16	out	out	ADP
bam-9610	107	17	someone	someone	PRON
bam-9610	107	18	else	else	ADV
bam-9610	107	19	's	's	PART
bam-9610	107	20	pain	pain	NOUN
bam-9610	107	21	or	or	CCONJ
bam-9610	107	22	limitations	limitation	NOUN
bam-9610	107	23	.	.	PUNCT
bam-9610	108	1	a	a	DET
bam-9610	108	2	person	person	NOUN
bam-9610	108	3	is	be	AUX
bam-9610	108	4	not	not	PART
bam-9610	108	5	quantifiable	quantifiable	ADJ
bam-9610	108	6	by	by	ADP
bam-9610	108	7	his	his	PRON
bam-9610	108	8	usefulness	usefulness	NOUN
bam-9610	108	9	and	and	CCONJ
bam-9610	108	10	a	a	DET
bam-9610	108	11	shift	shift	NOUN
bam-9610	108	12	in	in	ADP
bam-9610	108	13	emphasis	emphasis	NOUN
bam-9610	108	14	on	on	ADP
bam-9610	108	15	"	"	PUNCT
bam-9610	108	16	cost	cost	NOUN
bam-9610	108	17	recovery	recovery	NOUN
bam-9610	108	18	"	"	PUNCT
bam-9610	108	19	will	will	AUX
bam-9610	108	20	rather	rather	ADV
bam-9610	108	21	lead	lead	VERB
bam-9610	108	22	to	to	ADP
bam-9610	108	23	a	a	DET
bam-9610	108	24	deterioration	deterioration	NOUN
bam-9610	108	25	in	in	ADP
bam-9610	108	26	public	public	ADJ
bam-9610	108	27	health	health	NOUN
bam-9610	108	28	,	,	PUNCT
bam-9610	108	29	which	which	PRON
bam-9610	108	30	is	be	AUX
bam-9610	108	31	more	more	ADJ
bam-9610	108	32	than	than	ADP
bam-9610	108	33	an	an	DET
bam-9610	108	34	improvement	improvement	NOUN
bam-9610	108	35	in	in	ADP
bam-9610	108	36	the	the	DET
bam-9610	108	37	results	result	NOUN
bam-9610	108	38	of	of	ADP
bam-9610	108	39	treatment	treatment	NOUN
bam-9610	108	40	of	of	ADP
bam-9610	108	41	patients	patient	NOUN
bam-9610	108	42	taking	take	VERB
bam-9610	108	43	orphan	orphan	NOUN
bam-9610	108	44	drugs	drug	NOUN
bam-9610	108	45	.	.	PUNCT
bam-9610	109	1	there	there	PRON
bam-9610	109	2	is	be	VERB
bam-9610	109	3	a	a	DET
bam-9610	109	4	lack	lack	NOUN
bam-9610	109	5	of	of	ADP
bam-9610	109	6	evidence	evidence	NOUN
bam-9610	109	7	and	and	CCONJ
bam-9610	109	8	long	long	ADJ
bam-9610	109	9	-	-	PUNCT
bam-9610	109	10	term	term	NOUN
bam-9610	109	11	data	datum	NOUN
bam-9610	109	12	on	on	ADP
bam-9610	109	13	safety	safety	NOUN
bam-9610	109	14	and	and	CCONJ
bam-9610	109	15	efficacy	efficacy	NOUN
bam-9610	109	16	in	in	ADP
bam-9610	109	17	the	the	DET
bam-9610	109	18	treatment	treatment	NOUN
bam-9610	109	19	of	of	ADP
bam-9610	109	20	many	many	ADJ
bam-9610	109	21	orphan	orphan	NOUN
bam-9610	109	22	diseases	disease	NOUN
bam-9610	109	23	compared	compare	VERB
bam-9610	109	24	to	to	ADP
bam-9610	109	25	more	more	ADJ
bam-9610	109	26	studied	study	VERB
bam-9610	109	27	conditions	condition	NOUN
bam-9610	109	28	,	,	PUNCT
bam-9610	109	29	as	as	SCONJ
bam-9610	109	30	the	the	DET
bam-9610	109	31	results	result	NOUN
bam-9610	109	32	of	of	ADP
bam-9610	109	33	decades	decade	NOUN
bam-9610	109	34	of	of	ADP
bam-9610	109	35	research	research	NOUN
bam-9610	109	36	are	be	AUX
bam-9610	109	37	often	often	ADV
bam-9610	109	38	not	not	PART
bam-9610	109	39	used	use	VERB
bam-9610	109	40	for	for	ADP
bam-9610	109	41	orphan	orphan	NOUN
bam-9610	109	42	conditions	condition	NOUN
bam-9610	109	43	.	.	PUNCT
bam-9610	110	1	much	much	ADJ
bam-9610	110	2	of	of	ADP
bam-9610	110	3	the	the	DET
bam-9610	110	4	debate	debate	NOUN
bam-9610	110	5	about	about	ADP
bam-9610	110	6	health	health	NOUN
bam-9610	110	7	priorities	priority	NOUN
bam-9610	110	8	takes	take	VERB
bam-9610	110	9	the	the	DET
bam-9610	110	10	following	follow	VERB
bam-9610	110	11	form	form	NOUN
bam-9610	110	12	:	:	PUNCT
bam-9610	110	13	“	"	PUNCT
bam-9610	110	14	patients	patient	NOUN
bam-9610	110	15	a	a	PRON
bam-9610	110	16	and	and	CCONJ
bam-9610	110	17	b	b	NOUN
bam-9610	110	18	need	need	VERB
bam-9610	110	19	100	100	NUM
bam-9610	110	20	ml	ml	NOUN
bam-9610	110	21	of	of	ADP
bam-9610	110	22	medicine	medicine	NOUN
bam-9610	110	23	,	,	PUNCT
bam-9610	110	24	while	while	SCONJ
bam-9610	110	25	patient	patient	ADJ
bam-9610	110	26	c	c	PROPN
bam-9610	110	27	200	200	NUM
bam-9610	110	28	ml	ml	NOUN
bam-9610	110	29	.	.	PUNCT
bam-9610	111	1	should	should	AUX
bam-9610	111	2	we	we	PRON
bam-9610	111	3	treat	treat	VERB
bam-9610	111	4	a	a	PRON
bam-9610	111	5	and	and	CCONJ
bam-9610	111	6	b	b	NOUN
bam-9610	111	7	or	or	CCONJ
bam-9610	111	8	c	c	NOUN
bam-9610	111	9	?	?	PUNCT
bam-9610	111	10	”	"	PUNCT
bam-9610	112	1	–	–	PUNCT
bam-9610	112	2	this	this	PRON
bam-9610	112	3	is	be	AUX
bam-9610	112	4	unfair	unfair	ADJ
bam-9610	112	5	because	because	SCONJ
bam-9610	112	6	for	for	ADP
bam-9610	112	7	many	many	ADJ
bam-9610	112	8	people	people	NOUN
bam-9610	112	9	in	in	ADP
bam-9610	112	10	need	need	NOUN
bam-9610	112	11	of	of	ADP
bam-9610	112	12	life	life	NOUN
bam-9610	112	13	-	-	PUNCT
bam-9610	112	14	saving	save	VERB
bam-9610	112	15	therapy	therapy	NOUN
bam-9610	112	16	,	,	PUNCT
bam-9610	112	17	the	the	DET
bam-9610	112	18	effective	effective	ADJ
bam-9610	112	19	dosage	dosage	NOUN
bam-9610	112	20	and	and	CCONJ
bam-9610	112	21	cost	cost	NOUN
bam-9610	112	22	are	be	AUX
bam-9610	112	23	morally	morally	ADV
bam-9610	112	24	completely	completely	ADV
bam-9610	112	25	arbitrary	arbitrary	ADJ
bam-9610	112	26	.	.	PUNCT
bam-9610	113	1	after	after	ADV
bam-9610	113	2	all	all	ADV
bam-9610	113	3	,	,	PUNCT
bam-9610	113	4	the	the	DET
bam-9610	113	5	amount	amount	NOUN
bam-9610	113	6	of	of	ADP
bam-9610	113	7	medicine	medicine	NOUN
bam-9610	113	8	they	they	PRON
bam-9610	113	9	need	need	VERB
bam-9610	113	10	and	and	CCONJ
bam-9610	113	11	its	its	PRON
bam-9610	113	12	cost	cost	NOUN
bam-9610	113	13	did	do	AUX
bam-9610	113	14	not	not	PART
bam-9610	113	15	directly	directly	ADV
bam-9610	113	16	skyrocket	skyrocket	VERB
bam-9610	113	17	from	from	ADP
bam-9610	113	18	them	they	PRON
bam-9610	113	19	.	.	PUNCT
bam-9610	114	1	perhaps	perhaps	ADV
bam-9610	114	2	the	the	DET
bam-9610	114	3	only	only	ADJ
bam-9610	114	4	adequate	adequate	ADJ
bam-9610	114	5	question	question	NOUN
bam-9610	114	6	,	,	PUNCT
bam-9610	114	7	regardless	regardless	ADV
bam-9610	114	8	of	of	ADP
bam-9610	114	9	cost	cost	NOUN
bam-9610	114	10	and	and	CCONJ
bam-9610	114	11	dosage	dosage	NOUN
bam-9610	114	12	,	,	PUNCT
bam-9610	114	13	is	be	AUX
bam-9610	114	14	:	:	PUNCT
bam-9610	114	15	whether	whether	SCONJ
bam-9610	114	16	the	the	DET
bam-9610	114	17	drug	drug	NOUN
bam-9610	114	18	can	can	AUX
bam-9610	114	19	improve	improve	VERB
bam-9610	114	20	health	health	NOUN
bam-9610	114	21	or	or	CCONJ
bam-9610	114	22	at	at	ADP
bam-9610	114	23	least	least	ADJ
bam-9610	114	24	stabilize	stabilize	VERB
bam-9610	114	25	the	the	DET
bam-9610	114	26	manifestations	manifestation	NOUN
bam-9610	114	27	of	of	ADP
bam-9610	114	28	the	the	DET
bam-9610	114	29	disease	disease	NOUN
bam-9610	114	30	?	?	PUNCT
bam-9610	115	1	if	if	SCONJ
bam-9610	115	2	yes	yes	INTJ
bam-9610	115	3	,	,	PUNCT
bam-9610	115	4	the	the	DET
bam-9610	115	5	drug	drug	NOUN
bam-9610	115	6	must	must	AUX
bam-9610	115	7	be	be	AUX
bam-9610	115	8	covered	cover	VERB
bam-9610	115	9	for	for	ADP
bam-9610	115	10	all	all	DET
bam-9610	115	11	three	three	NUM
bam-9610	115	12	patients	patient	NOUN
bam-9610	115	13	a	a	DET
bam-9610	115	14	,	,	PUNCT
bam-9610	115	15	b	b	PROPN
bam-9610	115	16	and	and	CCONJ
bam-9610	115	17	c.	c.	PROPN
bam-9610	115	18	russian	russian	ADJ
bam-9610	115	19	government	government	NOUN
bam-9610	115	20	policies	policy	NOUN
bam-9610	115	21	,	,	PUNCT
bam-9610	115	22	problems	problem	NOUN
bam-9610	115	23	and	and	CCONJ
bam-9610	115	24	solutions	solution	NOUN
bam-9610	115	25	in	in	ADP
bam-9610	115	26	russian	russian	ADJ
bam-9610	115	27	federation	federation	PROPN
bam-9610	115	28	14	14	NUM
bam-9610	115	29	nosologies	nosology	NOUN
bam-9610	115	30	are	be	AUX
bam-9610	115	31	included	include	VERB
bam-9610	115	32	to	to	ADP
bam-9610	115	33	the	the	DET
bam-9610	115	34	«	«	PUNCT
bam-9610	115	35	register	register	NOUN
bam-9610	115	36	of	of	ADP
bam-9610	115	37	patients	patient	NOUN
bam-9610	115	38	with	with	ADP
bam-9610	115	39	life	life	NOUN
bam-9610	115	40	-	-	PUNCT
bam-9610	115	41	threatening	threaten	VERB
bam-9610	115	42	and	and	CCONJ
bam-9610	115	43	chronic	chronic	ADJ
bam-9610	115	44	progressive	progressive	ADJ
bam-9610	115	45	rare	rare	ADJ
bam-9610	115	46	(	(	PUNCT
bam-9610	115	47	orphan	orphan	NOUN
bam-9610	115	48	)	)	PUNCT
bam-9610	115	49	diseases	disease	NOUN
bam-9610	115	50	leading	lead	VERB
bam-9610	115	51	to	to	ADP
bam-9610	115	52	a	a	DET
bam-9610	115	53	reduction	reduction	NOUN
bam-9610	115	54	in	in	ADP
bam-9610	115	55	the	the	DET
bam-9610	115	56	life	life	NOUN
bam-9610	115	57	expectancy	expectancy	NOUN
bam-9610	115	58	of	of	ADP
bam-9610	115	59	citizens	citizen	NOUN
bam-9610	115	60	or	or	CCONJ
bam-9610	115	61	their	their	PRON
bam-9610	115	62	disability	disability	NOUN
bam-9610	115	63	»	»	NOUN
bam-9610	115	64	,	,	PUNCT
bam-9610	115	65	treatment	treatment	NOUN
bam-9610	115	66	of	of	ADP
bam-9610	115	67	these	these	DET
bam-9610	115	68	patients	patient	NOUN
bam-9610	115	69	comes	come	VERB
bam-9610	115	70	at	at	ADP
bam-9610	115	71	the	the	DET
bam-9610	115	72	expense	expense	NOUN
bam-9610	115	73	of	of	ADP
bam-9610	115	74	the	the	DET
bam-9610	115	75	federal	federal	ADJ
bam-9610	115	76	budget	budget	NOUN
bam-9610	115	77	.	.	PUNCT
bam-9610	116	1	among	among	ADP
bam-9610	116	2	these	these	DET
bam-9610	116	3	patients	patient	NOUN
bam-9610	116	4	,	,	PUNCT
bam-9610	116	5	there	there	PRON
bam-9610	116	6	are	be	VERB
bam-9610	116	7	no	no	DET
bam-9610	116	8	priorities	priority	NOUN
bam-9610	116	9	in	in	ADP
bam-9610	116	10	age	age	NOUN
bam-9610	116	11	,	,	PUNCT
bam-9610	116	12	type	type	NOUN
bam-9610	116	13	or	or	CCONJ
bam-9610	116	14	stage	stage	NOUN
bam-9610	116	15	of	of	ADP
bam-9610	116	16	the	the	DET
bam-9610	116	17	disease	disease	NOUN
bam-9610	116	18	for	for	ADP
bam-9610	116	19	medical	medical	ADJ
bam-9610	116	20	care	care	NOUN
bam-9610	116	21	and	and	CCONJ
bam-9610	116	22	drug	drug	NOUN
bam-9610	116	23	provision	provision	NOUN
bam-9610	116	24	.	.	PUNCT
bam-9610	117	1	in	in	ADP
bam-9610	117	2	accordance	accordance	NOUN
bam-9610	117	3	with	with	ADP
bam-9610	117	4	the	the	DET
bam-9610	117	5	legislation	legislation	NOUN
bam-9610	117	6	,	,	PUNCT
bam-9610	117	7	all	all	DET
bam-9610	117	8	patients	patient	NOUN
bam-9610	117	9	must	must	AUX
bam-9610	117	10	receive	receive	VERB
bam-9610	117	11	treatment.5,6	treatment.5,6	PROPN
bam-9610	117	12	in	in	ADP
bam-9610	117	13	the	the	DET
bam-9610	117	14	cases	case	NOUN
bam-9610	117	15	of	of	ADP
bam-9610	117	16	nosologies	nosology	NOUN
bam-9610	117	17	that	that	PRON
bam-9610	117	18	are	be	AUX
bam-9610	117	19	out	out	ADP
bam-9610	117	20	of	of	ADP
bam-9610	117	21	federal	federal	ADJ
bam-9610	117	22	budget	budget	NOUN
bam-9610	117	23	(	(	PUNCT
bam-9610	117	24	on	on	ADP
bam-9610	117	25	regional	regional	ADJ
bam-9610	117	26	budget	budget	NOUN
bam-9610	117	27	)	)	PUNCT
bam-9610	117	28	and	and	CCONJ
bam-9610	117	29	lack	lack	NOUN
bam-9610	117	30	of	of	ADP
bam-9610	117	31	available	available	ADJ
bam-9610	117	32	funds	fund	NOUN
bam-9610	117	33	in	in	ADP
bam-9610	117	34	this	this	DET
bam-9610	117	35	region	region	NOUN
bam-9610	117	36	a	a	DET
bam-9610	117	37	responsible	responsible	ADJ
bam-9610	117	38	person	person	NOUN
bam-9610	117	39	should	should	AUX
bam-9610	117	40	find	find	VERB
bam-9610	117	41	sources	source	NOUN
bam-9610	117	42	of	of	ADP
bam-9610	117	43	budgets	budget	NOUN
bam-9610	117	44	that	that	PRON
bam-9610	117	45	will	will	AUX
bam-9610	117	46	provide	provide	VERB
bam-9610	117	47	patients	patient	NOUN
bam-9610	117	48	with	with	ADP
bam-9610	117	49	the	the	DET
bam-9610	117	50	necessary	necessary	ADJ
bam-9610	117	51	therapy	therapy	NOUN
bam-9610	117	52	for	for	ADP
bam-9610	117	53	the	the	DET
bam-9610	117	54	required	require	VERB
bam-9610	117	55	period	period	NOUN
bam-9610	117	56	.	.	PUNCT
bam-9610	118	1	it	it	PRON
bam-9610	118	2	is	be	AUX
bam-9610	118	3	possible	possible	ADJ
bam-9610	118	4	to	to	PART
bam-9610	118	5	use	use	VERB
bam-9610	118	6	territorial	territorial	ADJ
bam-9610	118	7	obligatory	obligatory	ADJ
bam-9610	118	8	medical	medical	ADJ
bam-9610	118	9	insurance	insurance	NOUN
bam-9610	118	10	funds	fund	NOUN
bam-9610	118	11	or	or	CCONJ
bam-9610	118	12	apply	apply	VERB
bam-9610	118	13	individually	individually	ADV
bam-9610	118	14	to	to	ADP
bam-9610	118	15	the	the	DET
bam-9610	118	16	federal	federal	ADJ
bam-9610	118	17	budget	budget	NOUN
bam-9610	118	18	.	.	PUNCT
bam-9610	119	1	when	when	SCONJ
bam-9610	119	2	the	the	DET
bam-9610	119	3	problem	problem	NOUN
bam-9610	119	4	is	be	AUX
bam-9610	119	5	understood	understand	VERB
bam-9610	119	6	correctly	correctly	ADV
bam-9610	119	7	by	by	ADP
bam-9610	119	8	all	all	DET
bam-9610	119	9	participants	participant	NOUN
bam-9610	119	10	,	,	PUNCT
bam-9610	119	11	the	the	DET
bam-9610	119	12	issue	issue	NOUN
bam-9610	119	13	of	of	ADP
bam-9610	119	14	drugs	drug	NOUN
bam-9610	119	15	provision	provision	NOUN
bam-9610	119	16	to	to	ADP
bam-9610	119	17	the	the	DET
bam-9610	119	18	patient	patient	NOUN
bam-9610	119	19	with	with	ADP
bam-9610	119	20	rare	rare	ADJ
bam-9610	119	21	disease	disease	NOUN
bam-9610	119	22	is	be	AUX
bam-9610	119	23	always	always	ADV
bam-9610	119	24	resolved.5,6	resolved.5,6	VERB
bam-9610	119	25	since	since	SCONJ
bam-9610	119	26	2021	2021	NUM
bam-9610	119	27	,	,	PUNCT
bam-9610	119	28	on	on	ADP
bam-9610	119	29	behalf	behalf	NOUN
bam-9610	119	30	of	of	ADP
bam-9610	119	31	the	the	DET
bam-9610	119	32	president	president	NOUN
bam-9610	119	33	of	of	ADP
bam-9610	119	34	russian	russian	ADJ
bam-9610	119	35	federatoin	federatoin	NOUN
bam-9610	119	36	,	,	PUNCT
bam-9610	119	37	state	state	NOUN
bam-9610	119	38	fund	fund	NOUN
bam-9610	119	39	is	be	AUX
bam-9610	119	40	being	be	AUX
bam-9610	119	41	formed	form	VERB
bam-9610	119	42	and	and	CCONJ
bam-9610	119	43	by	by	ADP
bam-9610	119	44	increasing	increase	VERB
bam-9610	119	45	the	the	DET
bam-9610	119	46	tax	tax	NOUN
bam-9610	119	47	rate	rate	NOUN
bam-9610	119	48	on	on	ADP
bam-9610	119	49	personal	personal	ADJ
bam-9610	119	50	income	income	NOUN
bam-9610	119	51	for	for	ADP
bam-9610	119	52	citizens	citizen	NOUN
bam-9610	119	53	whose	whose	DET
bam-9610	119	54	income	income	NOUN
bam-9610	119	55	exceeds	exceed	VERB
bam-9610	119	56	five	five	NUM
bam-9610	119	57	million	million	NUM
bam-9610	119	58	rubles	ruble	NOUN
bam-9610	119	59	a	a	DET
bam-9610	119	60	year	year	NOUN
bam-9610	119	61	from	from	ADP
bam-9610	119	62	13	13	NUM
bam-9610	119	63	-	-	SYM
bam-9610	119	64	15	15	NUM
bam-9610	119	65	%	%	NOUN
bam-9610	119	66	,	,	PUNCT
bam-9610	119	67	the	the	DET
bam-9610	119	68	2	2	NUM
bam-9610	119	69	%	%	NOUN
bam-9610	119	70	received	receive	VERB
bam-9610	119	71	will	will	AUX
bam-9610	119	72	be	be	AUX
bam-9610	119	73	targeted	target	VERB
bam-9610	119	74	for	for	ADP
bam-9610	119	75	financing	finance	VERB
bam-9610	119	76	patients	patient	NOUN
bam-9610	119	77	with	with	ADP
bam-9610	119	78	orphan	orphan	NOUN
bam-9610	119	79	diseases	disease	NOUN
bam-9610	119	80	.	.	PUNCT
bam-9610	120	1	this	this	DET
bam-9610	120	2	structure	structure	NOUN
bam-9610	120	3	is	be	AUX
bam-9610	120	4	being	be	AUX
bam-9610	120	5	created	create	VERB
bam-9610	120	6	currently	currently	ADV
bam-9610	120	7	and	and	CCONJ
bam-9610	120	8	the	the	DET
bam-9610	120	9	whole	whole	ADJ
bam-9610	120	10	mechanism	mechanism	NOUN
bam-9610	120	11	is	be	AUX
bam-9610	120	12	worked	work	VERB
bam-9610	120	13	out	out	ADP
bam-9610	120	14	.	.	PUNCT
bam-9610	121	1	supervisory	supervisory	ADJ
bam-9610	121	2	council	council	PROPN
bam-9610	121	3	is	be	AUX
bam-9610	121	4	planned	plan	VERB
bam-9610	121	5	in	in	ADP
bam-9610	121	6	this	this	DET
bam-9610	121	7	structure	structure	NOUN
bam-9610	121	8	for	for	ADP
bam-9610	121	9	financing	financing	NOUN
bam-9610	121	10	mechanism	mechanism	NOUN
bam-9610	121	11	control	control	NOUN
bam-9610	121	12	and	and	CCONJ
bam-9610	121	13	funds	fund	VERB
bam-9610	121	14	distribution	distribution	NOUN
bam-9610	121	15	monitoring	monitoring	NOUN
bam-9610	121	16	.	.	PUNCT
bam-9610	122	1	integrated	integrate	VERB
bam-9610	122	2	work	work	NOUN
bam-9610	122	3	and	and	CCONJ
bam-9610	122	4	information	information	NOUN
bam-9610	122	5	exchange	exchange	NOUN
bam-9610	122	6	with	with	ADP
bam-9610	122	7	charitable	charitable	ADJ
bam-9610	122	8	foundations	foundation	NOUN
bam-9610	122	9	,	,	PUNCT
bam-9610	122	10	who	who	PRON
bam-9610	122	11	provide	provide	VERB
bam-9610	122	12	assistance	assistance	NOUN
bam-9610	122	13	for	for	ADP
bam-9610	122	14	patients	patient	NOUN
bam-9610	122	15	with	with	ADP
bam-9610	122	16	orphan	orphan	NOUN
bam-9610	122	17	diseases	disease	NOUN
bam-9610	122	18	and	and	CCONJ
bam-9610	122	19	interaction	interaction	NOUN
bam-9610	122	20	with	with	ADP
bam-9610	122	21	the	the	DET
bam-9610	122	22	subjects	subject	NOUN
bam-9610	122	23	of	of	ADP
bam-9610	122	24	russian	russian	ADJ
bam-9610	122	25	federation	federation	PROPN
bam-9610	122	26	,	,	PUNCT
bam-9610	122	27	are	be	AUX
bam-9610	122	28	essential	essential	ADJ
bam-9610	122	29	for	for	ADP
bam-9610	122	30	the	the	DET
bam-9610	122	31	targeted	target	VERB
bam-9610	122	32	financing	financing	NOUN
bam-9610	122	33	mechanism	mechanism	NOUN
bam-9610	122	34	in	in	ADP
bam-9610	122	35	patient	patient	NOUN
bam-9610	122	36	with	with	ADP
bam-9610	122	37	rare	rare	ADJ
bam-9610	122	38	diseases	disease	NOUN
bam-9610	122	39	.	.	PUNCT
bam-9610	123	1	conclusions	conclusion	NOUN
bam-9610	123	2	orphan	orphan	NOUN
bam-9610	123	3	diseases	disease	NOUN
bam-9610	123	4	represent	represent	VERB
bam-9610	123	5	a	a	DET
bam-9610	123	6	significant	significant	ADJ
bam-9610	123	7	social	social	ADJ
bam-9610	123	8	and	and	CCONJ
bam-9610	123	9	economic	economic	ADJ
bam-9610	123	10	burden	burden	NOUN
bam-9610	123	11	for	for	ADP
bam-9610	123	12	both	both	CCONJ
bam-9610	123	13	global	global	ADJ
bam-9610	123	14	and	and	CCONJ
bam-9610	123	15	russian	russian	ADJ
bam-9610	123	16	healthcare	healthcare	PROPN
bam-9610	123	17	.	.	PUNCT
bam-9610	124	1	the	the	DET
bam-9610	124	2	global	global	ADJ
bam-9610	124	3	burden	burden	NOUN
bam-9610	124	4	of	of	ADP
bam-9610	124	5	disease	disease	NOUN
bam-9610	124	6	metrics	metric	NOUN
bam-9610	124	7	introduced	introduce	VERB
bam-9610	124	8	by	by	ADP
bam-9610	124	9	who	who	PRON
bam-9610	124	10	,	,	PUNCT
bam-9610	124	11	such	such	ADJ
bam-9610	124	12	as	as	ADP
bam-9610	124	13	daly	daly	PROPN
bam-9610	124	14	,	,	PUNCT
bam-9610	124	15	qaly	qaly	PROPN
bam-9610	124	16	,	,	PUNCT
bam-9610	124	17	hale	hale	PROPN
bam-9610	124	18	,	,	PUNCT
bam-9610	124	19	can	can	AUX
bam-9610	124	20	be	be	AUX
bam-9610	124	21	a	a	DET
bam-9610	124	22	useful	useful	ADJ
bam-9610	124	23	tool	tool	NOUN
bam-9610	124	24	for	for	ADP
bam-9610	124	25	building	build	VERB
bam-9610	124	26	economic	economic	ADJ
bam-9610	124	27	models	model	NOUN
bam-9610	124	28	and	and	CCONJ
bam-9610	124	29	projections	projection	NOUN
bam-9610	124	30	,	,	PUNCT
bam-9610	124	31	as	as	ADV
bam-9610	124	32	well	well	ADV
bam-9610	124	33	as	as	ADP
bam-9610	124	34	allocating	allocate	VERB
bam-9610	124	35	funding	funding	NOUN
bam-9610	124	36	in	in	ADP
bam-9610	124	37	medicine	medicine	NOUN
bam-9610	124	38	.	.	PUNCT
bam-9610	125	1	however	however	ADV
bam-9610	125	2	,	,	PUNCT
bam-9610	125	3	it	it	PRON
bam-9610	125	4	is	be	AUX
bam-9610	125	5	difficult	difficult	ADJ
bam-9610	125	6	to	to	PART
bam-9610	125	7	standardize	standardize	VERB
bam-9610	125	8	a	a	DET
bam-9610	125	9	heterogeneous	heterogeneous	ADJ
bam-9610	125	10	group	group	NOUN
bam-9610	125	11	of	of	ADP
bam-9610	125	12	rare	rare	ADJ
bam-9610	125	13	diseases	disease	NOUN
bam-9610	125	14	and	and	CCONJ
bam-9610	125	15	it	it	PRON
bam-9610	125	16	is	be	AUX
bam-9610	125	17	difficult	difficult	ADJ
bam-9610	125	18	to	to	PART
bam-9610	125	19	talk	talk	VERB
bam-9610	125	20	about	about	ADP
bam-9610	125	21	finding	find	VERB
bam-9610	125	22	costevaluation	costevaluation	NOUN
bam-9610	125	23	of	of	ADP
bam-9610	125	24	orphan	orphan	NOUN
bam-9610	125	25	diseases	disease	NOUN
bam-9610	125	26	global	global	ADJ
bam-9610	125	27	burden	burden	PROPN
bam-9610	125	28	eur	eur	PROPN
bam-9610	125	29	j	j	PROPN
bam-9610	125	30	transl	transl	PROPN
bam-9610	125	31	myol	myol	NOUN
bam-9610	125	32	2021	2021	NUM
bam-9610	125	33	;	;	PUNCT
bam-9610	125	34	31	31	NUM
bam-9610	125	35	(	(	PUNCT
bam-9610	125	36	2	2	NUM
bam-9610	125	37	):	):	PUNCT
bam-9610	125	38	9610	9610	NUM
bam-9610	125	39	.	.	PUNCT
bam-9610	126	1	doi	doi	NOUN
bam-9610	126	2	:	:	PUNCT
bam-9610	126	3	10.4081	10.4081	NUM
bam-9610	126	4	/	/	SYM
bam-9610	126	5	ejtm.2021.9610	ejtm.2021.9610	VERB
bam-9610	126	6	7	7	NUM
bam-9610	126	7	effective	effective	ADJ
bam-9610	126	8	treatment	treatment	NOUN
bam-9610	126	9	options	option	NOUN
bam-9610	126	10	in	in	ADP
bam-9610	126	11	cases	case	NOUN
bam-9610	126	12	where	where	SCONJ
bam-9610	126	13	patients	patient	NOUN
bam-9610	126	14	with	with	ADP
bam-9610	126	15	a	a	DET
bam-9610	126	16	number	number	NOUN
bam-9610	126	17	of	of	ADP
bam-9610	126	18	orphan	orphan	NOUN
bam-9610	126	19	diseases	disease	NOUN
bam-9610	126	20	have	have	VERB
bam-9610	126	21	only	only	ADV
bam-9610	126	22	one	one	NUM
bam-9610	126	23	pathogenetic	pathogenetic	ADJ
bam-9610	126	24	therapy	therapy	NOUN
bam-9610	126	25	option	option	NOUN
bam-9610	126	26	.	.	PUNCT
bam-9610	127	1	a	a	DET
bam-9610	127	2	large	large	ADJ
bam-9610	127	3	amount	amount	NOUN
bam-9610	127	4	of	of	ADP
bam-9610	127	5	work	work	NOUN
bam-9610	127	6	must	must	AUX
bam-9610	127	7	be	be	AUX
bam-9610	127	8	done	do	VERB
bam-9610	127	9	to	to	PART
bam-9610	127	10	find	find	VERB
bam-9610	127	11	the	the	DET
bam-9610	127	12	optimal	optimal	ADJ
bam-9610	127	13	treatment	treatment	NOUN
bam-9610	127	14	options	option	NOUN
bam-9610	127	15	and	and	CCONJ
bam-9610	127	16	form	form	VERB
bam-9610	127	17	the	the	DET
bam-9610	127	18	standards	standard	NOUN
bam-9610	127	19	of	of	ADP
bam-9610	127	20	medical	medical	ADJ
bam-9610	127	21	care	care	NOUN
bam-9610	127	22	necessary	necessary	ADJ
bam-9610	127	23	to	to	PART
bam-9610	127	24	maintain	maintain	VERB
bam-9610	127	25	the	the	DET
bam-9610	127	26	physical	physical	ADJ
bam-9610	127	27	health	health	NOUN
bam-9610	127	28	,	,	PUNCT
bam-9610	127	29	ability	ability	NOUN
bam-9610	127	30	to	to	PART
bam-9610	127	31	work	work	VERB
bam-9610	127	32	and	and	CCONJ
bam-9610	127	33	the	the	DET
bam-9610	127	34	quality	quality	NOUN
bam-9610	127	35	of	of	ADP
bam-9610	127	36	life	life	NOUN
bam-9610	127	37	of	of	ADP
bam-9610	127	38	patients	patient	NOUN
bam-9610	127	39	with	with	ADP
bam-9610	127	40	orphan	orphan	NOUN
bam-9610	127	41	diseases	disease	NOUN
bam-9610	127	42	.	.	PUNCT
bam-9610	128	1	list	list	NOUN
bam-9610	128	2	of	of	ADP
bam-9610	128	3	acronyms	acronyms	PROPN
bam-9610	128	4	daly	daly	PROPN
bam-9610	128	5	disability	disability	PROPN
bam-9610	128	6	adjusted	adjust	VERB
bam-9610	128	7	life	life	NOUN
bam-9610	128	8	years	year	NOUN
bam-9610	128	9	gbd	gbd	NOUN
bam-9610	128	10	global	global	ADJ
bam-9610	128	11	burden	burden	NOUN
bam-9610	128	12	of	of	ADP
bam-9610	128	13	disease	disease	NOUN
bam-9610	128	14	hale	hale	PROPN
bam-9610	128	15	healthy	healthy	ADJ
bam-9610	128	16	life	life	NOUN
bam-9610	128	17	expectancy	expectancy	NOUN
bam-9610	128	18	who	who	PRON
bam-9610	128	19	world	world	NOUN
bam-9610	128	20	health	health	NOUN
bam-9610	128	21	organization	organization	PROPN
bam-9610	128	22	qaly	qaly	PROPN
bam-9610	128	23	quality	quality	PROPN
bam-9610	128	24	adjusted	adjust	VERB
bam-9610	128	25	life	life	NOUN
bam-9610	128	26	years	year	NOUN
bam-9610	128	27	author	author	NOUN
bam-9610	128	28	contributions	contribution	NOUN
bam-9610	128	29	em	em	PRON
bam-9610	128	30	,	,	PUNCT
bam-9610	128	31	article	article	NOUN
bam-9610	128	32	text	text	NOUN
bam-9610	128	33	;	;	PUNCT
bam-9610	128	34	ik	ik	PROPN
bam-9610	128	35	,	,	PUNCT
bam-9610	128	36	idea	idea	NOUN
bam-9610	128	37	and	and	CCONJ
bam-9610	128	38	concept	concept	NOUN
bam-9610	128	39	of	of	ADP
bam-9610	128	40	the	the	DET
bam-9610	128	41	review	review	NOUN
bam-9610	128	42	;	;	PUNCT
bam-9610	128	43	tv	tv	NOUN
bam-9610	128	44	,	,	PUNCT
bam-9610	128	45	informational	informational	ADJ
bam-9610	128	46	support	support	NOUN
bam-9610	128	47	;	;	PUNCT
bam-9610	128	48	mv	mv	ADJ
bam-9610	128	49	,	,	PUNCT
bam-9610	128	50	bibliographical	bibliographical	ADJ
bam-9610	128	51	search	search	NOUN
bam-9610	128	52	;	;	PUNCT
bam-9610	128	53	rz	rz	NOUN
bam-9610	128	54	,	,	PUNCT
bam-9610	128	55	scientific	scientific	ADJ
bam-9610	128	56	consultant	consultant	NOUN
bam-9610	128	57	;	;	PUNCT
bam-9610	128	58	acknowledgments	acknowledgment	NOUN
bam-9610	128	59	the	the	DET
bam-9610	128	60	authors	author	NOUN
bam-9610	128	61	thank	thank	VERB
bam-9610	128	62	colleagues	colleague	NOUN
bam-9610	128	63	of	of	ADP
bam-9610	128	64	the	the	DET
bam-9610	128	65	departments	department	NOUN
bam-9610	128	66	of	of	ADP
bam-9610	128	67	biomedical	biomedical	ADJ
bam-9610	128	68	sciences	sciences	PROPN
bam-9610	128	69	and	and	CCONJ
bam-9610	128	70	neurosciences	neuroscience	NOUN
bam-9610	128	71	,	,	PUNCT
bam-9610	128	72	university	university	NOUN
bam-9610	128	73	of	of	ADP
bam-9610	128	74	padova	padova	PROPN
bam-9610	128	75	,	,	PUNCT
bam-9610	128	76	italy	italy	PROPN
bam-9610	128	77	and	and	CCONJ
bam-9610	128	78	of	of	ADP
bam-9610	128	79	the	the	DET
bam-9610	128	80	a&c	a&c	PROPN
bam-9610	128	81	m	m	PROPN
bam-9610	128	82	-	-	PROPN
bam-9610	128	83	c	c	PROPN
bam-9610	128	84	foundation	foundation	NOUN
bam-9610	128	85	for	for	ADP
bam-9610	128	86	translational	translational	ADJ
bam-9610	128	87	myology	myology	NOUN
bam-9610	128	88	,	,	PUNCT
bam-9610	128	89	padova	padova	PROPN
bam-9610	128	90	,	,	PUNCT
bam-9610	128	91	italy	italy	PROPN
bam-9610	128	92	for	for	ADP
bam-9610	128	93	discussion	discussion	NOUN
bam-9610	128	94	and	and	CCONJ
bam-9610	128	95	critical	critical	ADJ
bam-9610	128	96	readings	reading	NOUN
bam-9610	128	97	.	.	PUNCT
bam-9610	129	1	funding	fund	VERB
bam-9610	129	2	none	none	NOUN
bam-9610	129	3	conflict	conflict	NOUN
bam-9610	129	4	of	of	ADP
bam-9610	129	5	interest	interest	NOUN
bam-9610	129	6	the	the	DET
bam-9610	129	7	authors	author	NOUN
bam-9610	129	8	declare	declare	VERB
bam-9610	129	9	they	they	PRON
bam-9610	129	10	have	have	VERB
bam-9610	129	11	no	no	DET
bam-9610	129	12	financial	financial	ADJ
bam-9610	129	13	,	,	PUNCT
bam-9610	129	14	personal	personal	ADJ
bam-9610	129	15	,	,	PUNCT
bam-9610	129	16	or	or	CCONJ
bam-9610	129	17	other	other	ADJ
bam-9610	129	18	conflicts	conflict	NOUN
bam-9610	129	19	of	of	ADP
bam-9610	129	20	interest	interest	NOUN
bam-9610	129	21	.	.	PUNCT
bam-9610	130	1	ethical	ethical	ADJ
bam-9610	130	2	publication	publication	NOUN
bam-9610	130	3	statement	statement	NOUN
bam-9610	130	4	we	we	PRON
bam-9610	130	5	confirm	confirm	VERB
bam-9610	130	6	that	that	SCONJ
bam-9610	130	7	we	we	PRON
bam-9610	130	8	have	have	AUX
bam-9610	130	9	read	read	VERB
bam-9610	130	10	the	the	DET
bam-9610	130	11	journal	journal	NOUN
bam-9610	130	12	’s	’s	PART
bam-9610	130	13	position	position	NOUN
bam-9610	130	14	on	on	ADP
bam-9610	130	15	issues	issue	NOUN
bam-9610	130	16	involved	involve	VERB
bam-9610	130	17	in	in	ADP
bam-9610	130	18	ethical	ethical	ADJ
bam-9610	130	19	publication	publication	NOUN
bam-9610	130	20	and	and	CCONJ
bam-9610	130	21	affirm	affirm	NOUN
bam-9610	130	22	that	that	SCONJ
bam-9610	130	23	this	this	DET
bam-9610	130	24	report	report	NOUN
bam-9610	130	25	is	be	AUX
bam-9610	130	26	consistent	consistent	ADJ
bam-9610	130	27	with	with	ADP
bam-9610	130	28	those	those	DET
bam-9610	130	29	guidelines	guideline	NOUN
bam-9610	130	30	.	.	PUNCT
bam-9610	131	1	corresponding	correspond	VERB
bam-9610	131	2	author	author	NOUN
bam-9610	131	3	ekaterina	ekaterina	PROPN
bam-9610	131	4	vladimirovna	vladimirovna	PROPN
bam-9610	131	5	makarova	makarova	PROPN
bam-9610	131	6	,	,	PUNCT
bam-9610	131	7	senior	senior	ADJ
bam-9610	131	8	research	research	NOUN
bam-9610	131	9	scientist	scientist	NOUN
bam-9610	131	10	,	,	PUNCT
bam-9610	131	11	fssbi	fssbi	ADJ
bam-9610	131	12	“	"	PUNCT
bam-9610	131	13	n.a	n.a	PROPN
bam-9610	131	14	.	.	PROPN
bam-9610	131	15	semashko	semashko	PROPN
bam-9610	131	16	national	national	PROPN
bam-9610	131	17	research	research	PROPN
bam-9610	131	18	institute	institute	PROPN
bam-9610	131	19	of	of	ADP
bam-9610	131	20	public	public	ADJ
bam-9610	131	21	health	health	NOUN
bam-9610	131	22	”	"	PUNCT
bam-9610	131	23	,	,	PUNCT
bam-9610	131	24	105064	105064	NUM
bam-9610	131	25	,	,	PUNCT
bam-9610	131	26	st	st	PROPN
bam-9610	131	27	.	.	PROPN
bam-9610	131	28	vorontsovo	vorontsovo	PROPN
bam-9610	131	29	field	field	PROPN
bam-9610	131	30	,	,	PUNCT
bam-9610	131	31	12	12	NUM
bam-9610	131	32	/	/	SYM
bam-9610	131	33	1c1	1c1	PROPN
bam-9610	131	34	,	,	PUNCT
bam-9610	131	35	moscow	moscow	PROPN
bam-9610	131	36	,	,	PUNCT
bam-9610	131	37	russia	russia	PROPN
bam-9610	131	38	.	.	PUNCT
bam-9610	132	1	phone	phone	NOUN
bam-9610	133	1	+7	+7	NOUN
bam-9610	133	2	915	915	NUM
bam-9610	133	3	111	111	NUM
bam-9610	133	4	4137	4137	NUM
bam-9610	133	5	.	.	PUNCT
bam-9610	134	1	orcid	orcid	NOUN
bam-9610	135	1	i	i	PRON
bam-9610	135	2	d	d	NOUN
bam-9610	135	3	:	:	PUNCT
bam-9610	135	4	0000	0000	NUM
bam-9610	135	5	-	-	PUNCT
bam-9610	135	6	0003	0003	NUM
bam-9610	135	7	-	-	PUNCT
bam-9610	135	8	2970	2970	NUM
bam-9610	135	9	-	-	SYM
bam-9610	135	10	6309	6309	NUM
bam-9610	135	11	e	e	NOUN
bam-9610	135	12	-	-	NOUN
bam-9610	135	13	mail	mail	NOUN
bam-9610	135	14	:	:	PUNCT
bam-9610	135	15	rue-royal@inbox.ru	rue-royal@inbox.ru	VERB
bam-9610	135	16	e	e	NOUN
bam-9610	135	17	-	-	NOUN
bam-9610	135	18	mails	mail	NOUN
bam-9610	135	19	and	and	CCONJ
bam-9610	135	20	orcid	orcid	NOUN
bam-9610	136	1	i	i	INTJ
bam-9610	136	2	d	d	PROPN
bam-9610	136	3	of	of	ADP
bam-9610	136	4	coauthors	coauthor	NOUN
bam-9610	136	5	ivan	ivan	PROPN
bam-9610	136	6	s	s	PROPN
bam-9610	136	7	krysanov	krysanov	PROPN
bam-9610	136	8	:	:	PUNCT
bam-9610	136	9	krysanov-ivan@mail.ru	krysanov-ivan@mail.ru	PROPN
bam-9610	136	10	orcid	orcid	NOUN
bam-9610	137	1	i	i	PRON
bam-9610	137	2	d	d	NOUN
bam-9610	137	3	:	:	PUNCT
bam-9610	137	4	0000	0000	NUM
bam-9610	137	5	-	-	PUNCT
bam-9610	137	6	0002	0002	NUM
bam-9610	137	7	-	-	PUNCT
bam-9610	137	8	3605	3605	NUM
bam-9610	137	9	-	-	SYM
bam-9610	137	10	8592	8592	NUM
bam-9610	137	11	tatiana	tatiana	PROPN
bam-9610	138	1	p	p	PROPN
bam-9610	138	2	vasilyeva	vasilyeva	PROPN
bam-9610	138	3	:	:	PUNCT
bam-9610	138	4	vasileva_tp@mail.ru	vasileva_tp@mail.ru	VERB
bam-9610	138	5	orcid	orcid	NOUN
bam-9610	138	6	i	i	PRON
bam-9610	138	7	d	d	NOUN
bam-9610	138	8	:	:	PUNCT
bam-9610	138	9	0000	0000	NUM
bam-9610	138	10	-	-	PUNCT
bam-9610	138	11	0002	0002	NUM
bam-9610	138	12	-	-	PUNCT
bam-9610	138	13	3605	3605	NUM
bam-9610	138	14	-	-	SYM
bam-9610	138	15	8592	8592	NUM
bam-9610	138	16	mikhail	mikhail	NOUN
bam-9610	138	17	d	d	NOUN
bam-9610	138	18	vasiliev	vasiliev	NOUN
bam-9610	138	19	:	:	PUNCT
bam-9610	138	20	m.vasilev@mail.ru	m.vasilev@mail.ru	X
bam-9610	139	1	orcid	orcid	NOUN
bam-9610	140	1	i	i	PRON
bam-9610	140	2	d	d	PROPN
bam-9610	140	3	:	:	PUNCT
bam-9610	140	4	0000‑0003‑1646‑7345	0000‑0003‑1646‑7345	NUM
bam-9610	140	5	rena	rena	PROPN
bam-9610	140	6	a	a	DET
bam-9610	140	7	zinchenko	zinchenko	PROPN
bam-9610	140	8	:	:	PUNCT
bam-9610	140	9	renazinchenko@mail.ru	renazinchenko@mail.ru	VERB
bam-9610	140	10	orcid	orcid	NOUN
bam-9610	141	1	i	i	PRON
bam-9610	141	2	d	d	NOUN
bam-9610	141	3	:	:	PUNCT
bam-9610	141	4	0000	0000	NUM
bam-9610	141	5	-	-	PUNCT
bam-9610	141	6	0003	0003	NUM
bam-9610	141	7	-	-	PUNCT
bam-9610	141	8	3586	3586	NUM
bam-9610	141	9	-	-	PUNCT
bam-9610	141	10	3458	3458	NUM
bam-9610	141	11	references	reference	NOUN
bam-9610	141	12	1	1	NUM
bam-9610	141	13	.	.	PUNCT
bam-9610	142	1	global	global	ADJ
bam-9610	142	2	burden	burden	NOUN
bam-9610	142	3	of	of	ADP
bam-9610	142	4	disease	disease	NOUN
bam-9610	142	5	:	:	PUNCT
bam-9610	142	6	generation	generation	NOUN
bam-9610	142	7	of	of	ADP
bam-9610	142	8	evidence	evidence	NOUN
bam-9610	142	9	,	,	PUNCT
bam-9610	142	10	policy	policy	NOUN
bam-9610	142	11	direction	direction	NOUN
bam-9610	142	12	.	.	PUNCT
bam-9610	143	1	health	health	NOUN
bam-9610	143	2	metricsand	metricsand	NOUN
bam-9610	143	3	evaluation	evaluation	NOUN
bam-9610	143	4	(	(	PUNCT
bam-9610	143	5	ihme	ihme	NOUN
bam-9610	143	6	)	)	PUNCT
bam-9610	143	7	.	.	PUNCT
bam-9610	144	1	university	university	PROPN
bam-9610	144	2	of	of	ADP
bam-9610	144	3	washington	washington	PROPN
bam-9610	144	4	,	,	PUNCT
bam-9610	144	5	human	human	ADJ
bam-9610	144	6	development	development	NOUN
bam-9610	144	7	network	network	NOUN
bam-9610	144	8	,	,	PUNCT
bam-9610	144	9	world	world	NOUN
bam-9610	144	10	bank	bank	PROPN
bam-9610	144	11	.	.	PUNCT
bam-9610	145	1	washington	washington	PROPN
bam-9610	145	2	dc	dc	PROPN
bam-9610	145	3	.	.	PROPN
bam-9610	145	4	2013	2013	NUM
bam-9610	145	5	.	.	PUNCT
bam-9610	146	1	46	46	NUM
bam-9610	146	2	p.	p.	NOUN
bam-9610	146	3	isbn	isbn	ADJ
bam-9610	146	4	978	978	NUM
bam-9610	146	5	-	-	SYM
bam-9610	146	6	0	0	NUM
bam-9610	146	7	-	-	PUNCT
bam-9610	146	8	9894752	9894752	NUM
bam-9610	146	9	-	-	SYM
bam-9610	146	10	5	5	NUM
bam-9610	146	11	-	-	SYM
bam-9610	146	12	9	9	NUM
bam-9610	146	13	.	.	NOUN
bam-9610	146	14	2	2	NUM
bam-9610	146	15	.	.	X
bam-9610	146	16	kosyakova	kosyakova	PROPN
bam-9610	146	17	nv	nv	PROPN
bam-9610	146	18	,	,	PUNCT
bam-9610	146	19	gavrilina	gavrilina	PROPN
bam-9610	146	20	ni	ni	PROPN
bam-9610	146	21	.	.	PROPN
bam-9610	146	22	orphan	orphan	NOUN
bam-9610	146	23	diseases	disease	NOUN
bam-9610	146	24	history	history	NOUN
bam-9610	146	25	of	of	ADP
bam-9610	146	26	the	the	DET
bam-9610	146	27	issue	issue	NOUN
bam-9610	146	28	and	and	CCONJ
bam-9610	146	29	modern	modern	ADJ
bam-9610	146	30	view	view	NOUN
bam-9610	146	31	of	of	ADP
bam-9610	146	32	the	the	DET
bam-9610	146	33	problem	problem	NOUN
bam-9610	146	34	.	.	PUNCT
bam-9610	147	1	modern	modern	ADJ
bam-9610	147	2	problems	problem	NOUN
bam-9610	147	3	of	of	ADP
bam-9610	147	4	science	science	NOUN
bam-9610	147	5	and	and	CCONJ
bam-9610	147	6	education	education	NOUN
bam-9610	147	7	.	.	PUNCT
bam-9610	148	1	2015	2015	NUM
bam-9610	148	2	;	;	PUNCT
bam-9610	148	3	2	2	NUM
bam-9610	148	4	.	.	SYM
bam-9610	148	5	3	3	NUM
bam-9610	148	6	.	.	X
bam-9610	148	7	orphanet	orphanet	PROPN
bam-9610	148	8	report	report	PROPN
bam-9610	148	9	series	series	PROPN
bam-9610	148	10	prevalence	prevalence	NOUN
bam-9610	148	11	of	of	ADP
bam-9610	148	12	rare	rare	ADJ
bam-9610	148	13	diseases	disease	NOUN
bam-9610	148	14	:	:	PUNCT
bam-9610	148	15	bibliographic	bibliographic	ADJ
bam-9610	148	16	data	datum	NOUN
bam-9610	148	17	january	january	PROPN
bam-9610	148	18	2020	2020	NUM
bam-9610	148	19	number	number	NOUN
bam-9610	148	20	1	1	NUM
bam-9610	148	21	.	.	PUNCT
bam-9610	148	22	available	available	ADJ
bam-9610	148	23	at	at	ADP
bam-9610	148	24	:	:	PUNCT
bam-9610	148	25	http://www.orpha.net/	http://www.orpha.net/	NOUN
bam-9610	148	26	orphacom	orphacom	PROPN
bam-9610	148	27	/	/	SYM
bam-9610	148	28	cahiers	cahier	NOUN
bam-9610	148	29	/	/	SYM
bam-9610	148	30	docs	doc	NOUN
bam-9610	148	31	/	/	SYM
bam-9610	148	32	gb	gb	PROPN
bam-9610	148	33	/	/	SYM
bam-9610	148	34	prevalence_of_rare_di	prevalence_of_rare_di	ADJ
bam-9610	148	35	seases_by_alphabetical_list.pdf	seases_by_alphabetical_list.pdf	NOUN
bam-9610	148	36	4	4	NUM
bam-9610	148	37	.	.	PUNCT
bam-9610	149	1	european	european	PROPN
bam-9610	149	2	medicines	medicine	NOUN
bam-9610	149	3	agency	agency	NOUN
bam-9610	149	4	annual	annual	ADJ
bam-9610	149	5	report	report	NOUN
bam-9610	149	6	on	on	ADP
bam-9610	149	7	the	the	DET
bam-9610	149	8	use	use	NOUN
bam-9610	149	9	of	of	ADP
bam-9610	149	10	the	the	DET
bam-9610	149	11	special	special	ADJ
bam-9610	149	12	contribution	contribution	NOUN
bam-9610	149	13	for	for	ADP
bam-9610	149	14	orphan	orphan	NOUN
bam-9610	149	15	medicinal	medicinal	ADJ
bam-9610	149	16	products	product	NOUN
bam-9610	149	17	(	(	PUNCT
bam-9610	149	18	2019	2019	NUM
bam-9610	149	19	)	)	PUNCT
bam-9610	149	20	available	available	ADJ
bam-9610	149	21	at	at	ADP
bam-9610	149	22	:	:	PUNCT
bam-9610	149	23	https://www.ema	https://www.ema	PROPN
bam-9610	149	24	.	.	PUNCT
bam-9610	150	1	europa.eu/en/documents/annual-report/annualreport-use-special-contribution-orphan-medicinal	europa.eu/en/documents/annual-report/annualreport-use-special-contribution-orphan-medicinal	ADJ
bam-9610	150	2	products-2019_en.pdf	products-2019_en.pdf	PROPN
bam-9610	150	3	.	.	PUNCT
bam-9610	151	1	5	5	NUM
bam-9610	151	2	.	.	X
bam-9610	151	3	volkova	volkova	PROPN
bam-9610	152	1	n.s	n.s	PROPN
bam-9610	152	2	.	.	PROPN
bam-9610	152	3	,	,	PUNCT
bam-9610	152	4	aksu	aksu	PROPN
bam-9610	152	5	e.	e.	PROPN
bam-9610	152	6	rare	rare	PROPN
bam-9610	152	7	(	(	PUNCT
bam-9610	152	8	orphan	orphan	NOUN
bam-9610	152	9	)	)	PUNCT
bam-9610	152	10	diseases	disease	NOUN
bam-9610	152	11	:	:	PUNCT
bam-9610	152	12	legal	legal	ADJ
bam-9610	152	13	regulation	regulation	NOUN
bam-9610	152	14	in	in	ADP
bam-9610	152	15	russia	russia	PROPN
bam-9610	152	16	and	and	CCONJ
bam-9610	152	17	abroad	abroad	ADV
bam-9610	152	18	.	.	PUNCT
bam-9610	153	1	journal	journal	NOUN
bam-9610	153	2	of	of	ADP
bam-9610	153	3	foreign	foreign	ADJ
bam-9610	153	4	law	law	NOUN
bam-9610	153	5	and	and	CCONJ
bam-9610	153	6	comparative	comparative	ADJ
bam-9610	153	7	law	law	NOUN
bam-9610	153	8	.	.	PUNCT
bam-9610	154	1	2018	2018	NUM
bam-9610	154	2	;	;	PUNCT
bam-9610	154	3	4	4	NUM
bam-9610	154	4	(	(	PUNCT
bam-9610	154	5	71	71	NUM
bam-9610	154	6	)	)	PUNCT
bam-9610	154	7	6	6	NUM
bam-9610	154	8	.	.	PUNCT
bam-9610	155	1	vasilieva	vasilieva	PROPN
bam-9610	155	2	tp	tp	PROPN
bam-9610	155	3	,	,	PUNCT
bam-9610	155	4	zinchenko	zinchenko	PROPN
bam-9610	155	5	ra	ra	PROPN
bam-9610	155	6	,	,	PUNCT
bam-9610	155	7	komarov	komarov	PROPN
bam-9610	155	8	ia	ia	PROPN
bam-9610	155	9	,	,	PUNCT
bam-9610	155	10	krasilnikova	krasilnikova	PROPN
bam-9610	155	11	eyu	eyu	PROPN
bam-9610	155	12	,	,	PUNCT
bam-9610	155	13	aleksandrova	aleksandrova	X
bam-9610	155	14	oyu	oyu	PROPN
bam-9610	155	15	,	,	PUNCT
bam-9610	155	16	konovalov	konovalov	PROPN
bam-9610	155	17	g.	g.	PROPN
bam-9610	155	18	,	,	PUNCT
bam-9610	155	19	kutsev	kutsev	VERB
bam-9610	155	20	si	si	PROPN
bam-9610	155	21	.	.	PROPN
bam-9610	156	1	the	the	DET
bam-9610	156	2	prevalence	prevalence	NOUN
bam-9610	156	3	and	and	CCONJ
bam-9610	156	4	diagnosis	diagnosis	NOUN
bam-9610	156	5	of	of	ADP
bam-9610	156	6	rare	rare	ADJ
bam-9610	156	7	(	(	PUNCT
bam-9610	156	8	orphan	orphan	NOUN
bam-9610	156	9	)	)	PUNCT
bam-9610	156	10	diseases	disease	NOUN
bam-9610	156	11	in	in	ADP
bam-9610	156	12	pediatric	pediatric	ADJ
bam-9610	156	13	population	population	NOUN
bam-9610	156	14	of	of	ADP
bam-9610	156	15	the	the	DET
bam-9610	156	16	russian	russian	PROPN
bam-9610	156	17	federation	federation	PROPN
bam-9610	156	18	.	.	PUNCT
bam-9610	157	1	pediatria	pediatria	PROPN
bam-9610	157	2	n.a	n.a	PROPN
bam-9610	157	3	.	.	PROPN
bam-9610	158	1	g.n	g.n	PROPN
bam-9610	158	2	.	.	PROPN
bam-9610	158	3	speransky	speransky	PROPN
bam-9610	158	4	.	.	PUNCT
bam-9610	159	1	2020	2020	NUM
bam-9610	159	2	;	;	PUNCT
bam-9610	159	3	99	99	NUM
bam-9610	159	4	(	(	PUNCT
bam-9610	159	5	4	4	NUM
bam-9610	159	6	):	):	PUNCT
bam-9610	159	7	229	229	NUM
bam-9610	159	8	-	-	SYM
bam-9610	159	9	237	237	NUM
bam-9610	159	10	.	.	PUNCT
bam-9610	160	1	doi	doi	NOUN
bam-9610	160	2	:	:	PUNCT
bam-9610	160	3	10.24110/0031	10.24110/0031	NUM
bam-9610	160	4	-	-	SYM
bam-9610	160	5	403x2020	403x2020	NUM
bam-9610	160	6	-	-	PUNCT
bam-9610	160	7	99	99	NUM
bam-9610	160	8	-	-	PUNCT
bam-9610	160	9	4	4	NUM
bam-9610	160	10	-	-	NUM
bam-9610	160	11	229	229	NUM
bam-9610	160	12	-	-	SYM
bam-9610	160	13	237	237	NUM
bam-9610	160	14	.	.	PUNCT
bam-9610	161	1	7	7	X
bam-9610	161	2	.	.	X
bam-9610	161	3	picavet	picavet	PROPN
bam-9610	161	4	e	e	PROPN
bam-9610	161	5	,	,	PUNCT
bam-9610	161	6	morel	morel	PROPN
bam-9610	161	7	t	t	PROPN
bam-9610	161	8	,	,	PUNCT
bam-9610	161	9	cassiman	cassiman	NOUN
bam-9610	161	10	d	d	PROPN
bam-9610	161	11	,	,	PUNCT
bam-9610	161	12	simoens	simoens	PROPN
bam-9610	161	13	s.	s.	PROPN
bam-9610	161	14	shining	shine	VERB
bam-9610	161	15	a	a	DET
bam-9610	161	16	light	light	NOUN
bam-9610	161	17	in	in	ADP
bam-9610	161	18	the	the	DET
bam-9610	161	19	black	black	ADJ
bam-9610	161	20	box	box	PROPN
bam-9610	161	21	of	of	ADP
bam-9610	161	22	orphan	orphan	NOUN
bam-9610	161	23	drug	drug	NOUN
bam-9610	161	24	pricing	pricing	NOUN
bam-9610	161	25	.	.	PUNCT
bam-9610	162	1	orphanet	orphanet	PROPN
bam-9610	162	2	j	j	PROPN
bam-9610	162	3	rare	rare	ADJ
bam-9610	162	4	dis	dis	PROPN
bam-9610	162	5	.	.	PUNCT
bam-9610	163	1	2014	2014	NUM
bam-9610	163	2	apr	apr	NOUN
bam-9610	163	3	27;9:62	27;9:62	NUM
bam-9610	163	4	.	.	PUNCT
bam-9610	164	1	doi	doi	NOUN
bam-9610	164	2	:	:	PUNCT
bam-9610	164	3	10.1186/1750	10.1186/1750	NUM
bam-9610	164	4	-	-	SYM
bam-9610	164	5	1172	1172	NUM
bam-9610	164	6	-	-	PUNCT
bam-9610	164	7	9	9	NUM
bam-9610	164	8	-	-	SYM
bam-9610	164	9	62	62	NUM
bam-9610	164	10	.	.	PUNCT
bam-9610	165	1	8	8	NUM
bam-9610	165	2	.	.	X
bam-9610	165	3	yagudina	yagudina	PROPN
bam-9610	165	4	ri	ri	PROPN
bam-9610	165	5	,	,	PUNCT
bam-9610	165	6	molchanova	molchanova	PROPN
bam-9610	165	7	nb	nb	PROPN
bam-9610	165	8	.	.	PUNCT
bam-9610	166	1	analysis	analysis	NOUN
bam-9610	166	2	of	of	ADP
bam-9610	166	3	healthcare	healthcare	NOUN
bam-9610	166	4	system	system	NOUN
bam-9610	166	5	costs	cost	NOUN
bam-9610	166	6	for	for	ADP
bam-9610	166	7	drug	drug	NOUN
bam-9610	166	8	therapy	therapy	NOUN
bam-9610	166	9	for	for	ADP
bam-9610	166	10	patients	patient	NOUN
bam-9610	166	11	with	with	ADP
bam-9610	166	12	hemophilia	hemophilia	PROPN
bam-9610	166	13	a	a	PRON
bam-9610	166	14	based	base	VERB
bam-9610	166	15	on	on	ADP
bam-9610	166	16	treatment	treatment	NOUN
bam-9610	166	17	standards	standard	NOUN
bam-9610	166	18	,	,	PUNCT
bam-9610	166	19	clinical	clinical	ADJ
bam-9610	166	20	guidelines	guideline	NOUN
bam-9610	166	21	and	and	CCONJ
bam-9610	166	22	selected	select	VERB
bam-9610	166	23	drug	drug	NOUN
bam-9610	166	24	groups	group	NOUN
bam-9610	166	25	.	.	PUNCT
bam-9610	167	1	quality	quality	NOUN
bam-9610	167	2	assurance	assurance	NOUN
bam-9610	167	3	issues	issue	NOUN
bam-9610	167	4	for	for	ADP
bam-9610	167	5	medicines	medicine	NOUN
bam-9610	167	6	.	.	PUNCT
bam-9610	168	1	2016	2016	NUM
bam-9610	168	2	;	;	PUNCT
bam-9610	168	3	3	3	NUM
bam-9610	168	4	(	(	PUNCT
bam-9610	168	5	13	13	NUM
bam-9610	168	6	):	):	PUNCT
bam-9610	168	7	29	29	NUM
bam-9610	168	8	-	-	SYM
bam-9610	168	9	41	41	NUM
bam-9610	168	10	.	.	NOUN
bam-9610	169	1	9	9	NUM
bam-9610	169	2	.	.	X
bam-9610	169	3	kolbin	kolbin	PROPN
bam-9610	169	4	as	as	ADP
bam-9610	169	5	,	,	PUNCT
bam-9610	169	6	vilyum	vilyum	PROPN
bam-9610	169	7	ia	ia	PROPN
bam-9610	169	8	,	,	PUNCT
bam-9610	169	9	proskurin	proskurin	PROPN
bam-9610	169	10	ma	ma	PROPN
bam-9610	169	11	,	,	PUNCT
bam-9610	169	12	balykina	balykina	PROPN
bam-9610	169	13	ye	ye	NOUN
bam-9610	169	14	.	.	PUNCT
bam-9610	170	1	[	[	X
bam-9610	170	2	pharmacoeconomic	pharmacoeconomic	ADJ
bam-9610	170	3	analysis	analysis	NOUN
bam-9610	170	4	of	of	ADP
bam-9610	170	5	using	use	VERB
bam-9610	170	6	mirabegron	mirabegron	PROPN
bam-9610	170	7	to	to	PART
bam-9610	170	8	treat	treat	VERB
bam-9610	170	9	overactive	overactive	ADJ
bam-9610	170	10	bladder	bladder	NOUN
bam-9610	170	11	in	in	ADP
bam-9610	170	12	the	the	DET
bam-9610	170	13	setting	setting	NOUN
bam-9610	170	14	of	of	ADP
bam-9610	170	15	the	the	DET
bam-9610	170	16	russian	russian	PROPN
bam-9610	170	17	federation	federation	PROPN
bam-9610	170	18	health	health	PROPN
bam-9610	170	19	care	care	PROPN
bam-9610	170	20	]	]	PUNCT
bam-9610	170	21	.	.	PUNCT
bam-9610	171	1	urologiia	urologiia	PROPN
bam-9610	171	2	.	.	PUNCT
bam-9610	172	1	2016	2016	NUM
bam-9610	172	2	feb;(1):32	feb;(1):32	NOUN
bam-9610	172	3	-	-	PUNCT
bam-9610	172	4	39	39	NUM
bam-9610	172	5	.	.	PUNCT
bam-9610	173	1	russian	russian	ADJ
bam-9610	173	2	.	.	PUNCT
bam-9610	174	1	10	10	NUM
bam-9610	174	2	.	.	X
bam-9610	174	3	walker	walker	PROPN
bam-9610	174	4	ce	ce	PROPN
bam-9610	174	5	,	,	PUNCT
bam-9610	174	6	mahede	mahede	PROPN
bam-9610	174	7	t	t	PROPN
bam-9610	174	8	,	,	PUNCT
bam-9610	174	9	davis	davis	PROPN
bam-9610	174	10	g	g	PROPN
bam-9610	174	11	,	,	PUNCT
bam-9610	174	12	miller	miller	PROPN
bam-9610	174	13	lj	lj	PROPN
bam-9610	174	14	,	,	PUNCT
bam-9610	174	15	girschik	girschik	PROPN
bam-9610	174	16	j	j	PROPN
bam-9610	174	17	,	,	PUNCT
bam-9610	174	18	brameld	brameld	VERB
bam-9610	174	19	k	k	PROPN
bam-9610	174	20	,	,	PUNCT
bam-9610	174	21	sun	sun	PROPN
bam-9610	174	22	w	w	PROPN
bam-9610	174	23	,	,	PUNCT
bam-9610	174	24	rath	rath	PROPN
bam-9610	174	25	a	a	X
bam-9610	174	26	,	,	PUNCT
bam-9610	174	27	aymé	aymé	PROPN
bam-9610	174	28	s	s	PROPN
bam-9610	174	29	,	,	PUNCT
bam-9610	174	30	zubrick	zubrick	PROPN
bam-9610	174	31	sr	sr	PROPN
bam-9610	174	32	,	,	PUNCT
bam-9610	174	33	baynam	baynam	NOUN
bam-9610	174	34	gs	gs	NOUN
bam-9610	174	35	,	,	PUNCT
bam-9610	174	36	molster	molster	PROPN
bam-9610	174	37	c	c	NOUN
bam-9610	174	38	,	,	PUNCT
bam-9610	174	39	dawkins	dawkin	VERB
bam-9610	174	40	hjs	hjs	PROPN
bam-9610	174	41	,	,	PUNCT
bam-9610	174	42	weeramanthri	weeramanthri	NOUN
bam-9610	174	43	ts	ts	NOUN
bam-9610	174	44	.	.	PUNCT
bam-9610	175	1	the	the	DET
bam-9610	175	2	collective	collective	ADJ
bam-9610	175	3	impact	impact	NOUN
bam-9610	175	4	of	of	ADP
bam-9610	175	5	rare	rare	ADJ
bam-9610	175	6	diseases	disease	NOUN
bam-9610	175	7	in	in	ADP
bam-9610	175	8	western	western	ADJ
bam-9610	175	9	australia	australia	PROPN
bam-9610	175	10	:	:	PUNCT
bam-9610	175	11	an	an	DET
bam-9610	175	12	estimate	estimate	NOUN
bam-9610	175	13	using	use	VERB
bam-9610	175	14	a	a	DET
bam-9610	175	15	population	population	NOUN
bam-9610	175	16	-	-	PUNCT
bam-9610	175	17	based	base	VERB
bam-9610	175	18	cohort	cohort	NOUN
bam-9610	175	19	.	.	PUNCT
bam-9610	176	1	genet	genet	PROPN
bam-9610	176	2	med	med	PROPN
bam-9610	176	3	.	.	PROPN
bam-9610	177	1	2017	2017	NUM
bam-9610	177	2	may;19(5):546	may;19(5):546	NOUN
bam-9610	177	3	-	-	SYM
bam-9610	177	4	552	552	NUM
bam-9610	177	5	.	.	PUNCT
bam-9610	178	1	doi	doi	NOUN
bam-9610	178	2	:	:	PUNCT
bam-9610	178	3	10.1038	10.1038	NUM
bam-9610	178	4	/	/	SYM
bam-9610	178	5	gim.2016.143	gim.2016.143	NOUN
bam-9610	178	6	.	.	PUNCT
bam-9610	179	1	epub	epub	PROPN
bam-9610	179	2	2016	2016	NUM
bam-9610	179	3	sep	sep	NOUN
bam-9610	179	4	22	22	NUM
bam-9610	179	5	.	.	PUNCT
bam-9610	180	1	11	11	NUM
bam-9610	180	2	.	.	PUNCT
bam-9610	181	1	yoong	yoong	PROPN
bam-9610	181	2	sl	sl	PROPN
bam-9610	181	3	,	,	PUNCT
bam-9610	181	4	hall	hall	NOUN
bam-9610	181	5	a	a	NOUN
bam-9610	181	6	,	,	PUNCT
bam-9610	181	7	williams	williams	PROPN
bam-9610	181	8	cm	cm	PROPN
bam-9610	181	9	,	,	PUNCT
bam-9610	181	10	skelton	skelton	PROPN
bam-9610	181	11	e	e	PROPN
bam-9610	181	12	,	,	PUNCT
bam-9610	181	13	oldmeadow	oldmeadow	X
bam-9610	181	14	c	c	NOUN
bam-9610	181	15	,	,	PUNCT
bam-9610	181	16	wiggers	wiggers	PROPN
bam-9610	181	17	j	j	PROPN
bam-9610	181	18	,	,	PUNCT
bam-9610	181	19	karimkhani	karimkhani	PROPN
bam-9610	181	20	c	c	PROPN
bam-9610	181	21	,	,	PUNCT
bam-9610	181	22	boyers	boyer	NOUN
bam-9610	181	23	ln	ln	ADJ
bam-9610	181	24	,	,	PUNCT
bam-9610	181	25	dellavalle	dellavalle	NOUN
bam-9610	181	26	rp	rp	NOUN
bam-9610	181	27	,	,	PUNCT
bam-9610	181	28	hilton	hilton	PROPN
bam-9610	181	29	j	j	PROPN
bam-9610	181	30	,	,	PUNCT
bam-9610	181	31	wolfenden	wolfenden	ADJ
bam-9610	181	32	l.	l.	PROPN
bam-9610	181	33	alignment	alignment	NOUN
bam-9610	181	34	of	of	ADP
bam-9610	181	35	systematic	systematic	ADJ
bam-9610	181	36	reviews	review	NOUN
bam-9610	181	37	published	publish	VERB
bam-9610	181	38	in	in	ADP
bam-9610	181	39	the	the	DET
bam-9610	181	40	cochrane	cochrane	NOUN
bam-9610	181	41	database	database	NOUN
bam-9610	181	42	of	of	ADP
bam-9610	181	43	systematic	systematic	ADJ
bam-9610	181	44	reviews	review	NOUN
bam-9610	181	45	and	and	CCONJ
bam-9610	181	46	the	the	DET
bam-9610	181	47	database	database	NOUN
bam-9610	181	48	of	of	ADP
bam-9610	181	49	abstracts	abstract	NOUN
bam-9610	181	50	and	and	CCONJ
bam-9610	181	51	reviews	review	NOUN
bam-9610	181	52	of	of	ADP
bam-9610	181	53	effectiveness	effectiveness	NOUN
bam-9610	181	54	with	with	ADP
bam-9610	181	55	global	global	ADJ
bam-9610	181	56	burden	burden	NOUN
bam-9610	181	57	-	-	PUNCT
bam-9610	181	58	of	of	ADP
bam-9610	181	59	-	-	PUNCT
bam-9610	181	60	disease	disease	NOUN
bam-9610	181	61	data	datum	NOUN
bam-9610	181	62	:	:	PUNCT
bam-9610	181	63	a	a	DET
bam-9610	181	64	bibliographic	bibliographic	ADJ
bam-9610	181	65	analysis	analysis	NOUN
bam-9610	181	66	.	.	PUNCT
bam-9610	182	1	j	j	PROPN
bam-9610	182	2	epidemiol	epidemiol	PROPN
bam-9610	182	3	community	community	PROPN
bam-9610	182	4	health	health	NOUN
bam-9610	182	5	.	.	PUNCT
bam-9610	183	1	2015	2015	NUM
bam-9610	183	2	https://orcid.org/0000-0003-2970-6309	https://orcid.org/0000-0003-2970-6309	NOUN
bam-9610	183	3	mailto:rue-royal@inbox.ru	mailto:rue-royal@inbox.ru	AUX
bam-9610	183	4	mailto:krysanov-ivan@mail.ru	mailto:krysanov-ivan@mail.ru	VERB
bam-9610	183	5	mailto:vasileva_tp@mail.ru	mailto:vasileva_tp@mail.ru	AUX
bam-9610	183	6	mailto:m.vasilev@mail.ru	mailto:m.vasilev@mail.ru	ADV
bam-9610	183	7	mailto:renazinchenko@mail.ru	mailto:renazinchenko@mail.ru	VERB
bam-9610	183	8	http://www.orpha.net/	http://www.orpha.net/	NOUN
bam-9610	183	9	evaluation	evaluation	NOUN
bam-9610	183	10	of	of	ADP
bam-9610	183	11	orphan	orphan	NOUN
bam-9610	183	12	diseases	disease	NOUN
bam-9610	183	13	global	global	ADJ
bam-9610	183	14	burden	burden	PROPN
bam-9610	183	15	eur	eur	PROPN
bam-9610	183	16	j	j	PROPN
bam-9610	183	17	transl	transl	PROPN
bam-9610	183	18	myol	myol	NOUN
bam-9610	183	19	2021	2021	NUM
bam-9610	183	20	;	;	PUNCT
bam-9610	183	21	31	31	NUM
bam-9610	183	22	(	(	PUNCT
bam-9610	183	23	2	2	NUM
bam-9610	183	24	):	):	PUNCT
bam-9610	183	25	9610	9610	NUM
bam-9610	183	26	.	.	PUNCT
bam-9610	184	1	doi	doi	NOUN
bam-9610	184	2	:	:	PUNCT
bam-9610	184	3	10.4081	10.4081	NUM
bam-9610	184	4	/	/	SYM
bam-9610	184	5	ejtm.2021.9610	ejtm.2021.9610	NUM
bam-9610	184	6	8	8	NUM
bam-9610	184	7	jul;69(7):708	jul;69(7):708	NUM
bam-9610	184	8	-	-	SYM
bam-9610	184	9	14	14	NUM
bam-9610	184	10	.	.	PUNCT
bam-9610	185	1	doi	doi	NOUN
bam-9610	185	2	:	:	PUNCT
bam-9610	185	3	10.1136	10.1136	NUM
bam-9610	185	4	/	/	SYM
bam-9610	185	5	jech-2014	jech-2014	NOUN
bam-9610	185	6	-	-	PUNCT
bam-9610	185	7	205389	205389	NUM
bam-9610	185	8	.	.	PUNCT
bam-9610	186	1	epub	epub	NOUN
bam-9610	186	2	2015	2015	NUM
bam-9610	186	3	apr	apr	NOUN
bam-9610	186	4	17	17	NUM
bam-9610	186	5	.	.	PUNCT
bam-9610	187	1	12	12	NUM
bam-9610	187	2	.	.	PUNCT
bam-9610	188	1	vallabhaneni	vallabhaneni	PROPN
bam-9610	188	2	s	s	PROPN
bam-9610	188	3	,	,	PUNCT
bam-9610	188	4	mody	mody	PROPN
bam-9610	188	5	rk	rk	NOUN
bam-9610	188	6	,	,	PUNCT
bam-9610	188	7	walker	walker	PROPN
bam-9610	188	8	t	t	PROPN
bam-9610	188	9	,	,	PUNCT
bam-9610	188	10	chiller	chiller	NOUN
bam-9610	188	11	t.	t.	NOUN
bam-9610	188	12	the	the	DET
bam-9610	188	13	global	global	ADJ
bam-9610	188	14	burden	burden	NOUN
bam-9610	188	15	of	of	ADP
bam-9610	188	16	fungal	fungal	ADJ
bam-9610	188	17	diseases	disease	NOUN
bam-9610	188	18	.	.	PUNCT
bam-9610	189	1	infect	infect	VERB
bam-9610	189	2	dis	dis	PROPN
bam-9610	189	3	clin	clin	PROPN
bam-9610	189	4	north	north	PROPN
bam-9610	189	5	am	am	PROPN
bam-9610	189	6	.	.	PUNCT
bam-9610	190	1	2016	2016	NUM
bam-9610	190	2	mar;30(1):1	mar;30(1):1	NOUN
bam-9610	190	3	-	-	PUNCT
bam-9610	190	4	11	11	NUM
bam-9610	190	5	.	.	PUNCT
bam-9610	191	1	doi	doi	NOUN
bam-9610	191	2	:	:	PUNCT
bam-9610	191	3	10.1016	10.1016	NUM
bam-9610	191	4	/	/	SYM
bam-9610	191	5	j.idc.2015.10.004	j.idc.2015.10.004	PROPN
bam-9610	191	6	.	.	PUNCT
bam-9610	192	1	epub	epub	PROPN
bam-9610	192	2	2015	2015	NUM
bam-9610	192	3	dec	dec	PROPN
bam-9610	192	4	29	29	NUM
bam-9610	192	5	.	.	PUNCT
bam-9610	193	1	13	13	NUM
bam-9610	193	2	.	.	X
bam-9610	194	1	who	who	PRON
bam-9610	194	2	methods	method	VERB
bam-9610	194	3	and	and	CCONJ
bam-9610	194	4	data	datum	NOUN
bam-9610	194	5	sources	source	NOUN
bam-9610	194	6	for	for	ADP
bam-9610	194	7	global	global	ADJ
bam-9610	194	8	burden	burden	NOUN
bam-9610	194	9	of	of	ADP
bam-9610	194	10	disease	disease	NOUN
bam-9610	194	11	estimates	estimate	VERB
bam-9610	194	12	2000	2000	NUM
bam-9610	194	13	-	-	SYM
bam-9610	194	14	2016	2016	NUM
bam-9610	194	15	.	.	PUNCT
bam-9610	195	1	available	available	ADJ
bam-9610	195	2	at	at	ADP
bam-9610	195	3	:	:	PUNCT
bam-9610	195	4	https://www.who.int/healthinfo/global_burden_dis	https://www.who.int/healthinfo/global_burden_dis	NUM
bam-9610	195	5	ease	ease	VERB
bam-9610	195	6	/	/	SYM
bam-9610	195	7	globaldaly_method_2000_2016.pdf	globaldaly_method_2000_2016.pdf	NOUN
bam-9610	195	8	14	14	NUM
bam-9610	195	9	.	.	PUNCT
bam-9610	196	1	gbd	gbd	NOUN
bam-9610	196	2	2016	2016	NUM
bam-9610	196	3	dalys	daly	NOUN
bam-9610	196	4	and	and	CCONJ
bam-9610	196	5	hale	hale	PROPN
bam-9610	196	6	collaborators	collaborator	NOUN
bam-9610	196	7	.	.	PUNCT
bam-9610	197	1	global	global	ADJ
bam-9610	197	2	,	,	PUNCT
bam-9610	197	3	regional	regional	ADJ
bam-9610	197	4	,	,	PUNCT
bam-9610	197	5	and	and	CCONJ
bam-9610	197	6	national	national	ADJ
bam-9610	197	7	disability	disability	NOUN
bam-9610	197	8	-	-	PUNCT
bam-9610	197	9	adjusted	adjust	VERB
bam-9610	197	10	life	life	NOUN
bam-9610	197	11	-	-	PUNCT
bam-9610	197	12	years	year	NOUN
bam-9610	197	13	(	(	PUNCT
bam-9610	197	14	dalys	daly	NOUN
bam-9610	197	15	)	)	PUNCT
bam-9610	197	16	for	for	ADP
bam-9610	197	17	333	333	NUM
bam-9610	197	18	diseases	disease	NOUN
bam-9610	197	19	and	and	CCONJ
bam-9610	197	20	injuries	injury	NOUN
bam-9610	197	21	and	and	CCONJ
bam-9610	197	22	healthy	healthy	ADJ
bam-9610	197	23	life	life	NOUN
bam-9610	197	24	expectancy	expectancy	NOUN
bam-9610	197	25	(	(	PUNCT
bam-9610	197	26	hale	hale	PROPN
bam-9610	197	27	)	)	PUNCT
bam-9610	197	28	for	for	ADP
bam-9610	197	29	195	195	NUM
bam-9610	197	30	countries	country	NOUN
bam-9610	197	31	and	and	CCONJ
bam-9610	197	32	territories	territory	NOUN
bam-9610	197	33	,	,	PUNCT
bam-9610	197	34	1990	1990	NUM
bam-9610	197	35	-	-	SYM
bam-9610	197	36	2016	2016	NUM
bam-9610	197	37	:	:	PUNCT
bam-9610	197	38	a	a	DET
bam-9610	197	39	systematic	systematic	ADJ
bam-9610	197	40	analysis	analysis	NOUN
bam-9610	197	41	for	for	ADP
bam-9610	197	42	the	the	DET
bam-9610	197	43	global	global	ADJ
bam-9610	197	44	burden	burden	NOUN
bam-9610	197	45	of	of	ADP
bam-9610	197	46	disease	disease	NOUN
bam-9610	197	47	study	study	NOUN
bam-9610	197	48	2016	2016	NUM
bam-9610	197	49	.	.	PUNCT
bam-9610	198	1	lancet	lancet	NOUN
bam-9610	198	2	.	.	PUNCT
bam-9610	199	1	2017	2017	NUM
bam-9610	199	2	sep	sep	NOUN
bam-9610	199	3	16;390(10100):1260	16;390(10100):1260	NUM
bam-9610	199	4	-	-	SYM
bam-9610	199	5	1344	1344	NUM
bam-9610	199	6	.	.	PUNCT
bam-9610	200	1	doi	doi	NOUN
bam-9610	200	2	:	:	PUNCT
bam-9610	200	3	10.1016	10.1016	NUM
bam-9610	200	4	/	/	SYM
bam-9610	200	5	s0140	s0140	PROPN
bam-9610	200	6	-	-	PUNCT
bam-9610	200	7	6736(17)32130	6736(17)32130	NOUN
bam-9610	200	8	-	-	PUNCT
bam-9610	200	9	x.	x.	NOUN
bam-9610	200	10	erratum	erratum	PROPN
bam-9610	200	11	in	in	ADP
bam-9610	200	12	:	:	PUNCT
bam-9610	200	13	lancet	lancet	NOUN
bam-9610	200	14	.	.	PUNCT
bam-9610	201	1	2017	2017	NUM
bam-9610	201	2	oct	oct	NOUN
bam-9610	201	3	28;390(10106):e38	28;390(10106):e38	NUM
bam-9610	201	4	.	.	PUNCT
bam-9610	202	1	15	15	NUM
bam-9610	202	2	.	.	PUNCT
bam-9610	202	3	hyry	hyry	PROPN
bam-9610	202	4	hi	hi	PROPN
bam-9610	202	5	,	,	PUNCT
bam-9610	202	6	stern	stern	ADJ
bam-9610	202	7	ad	ad	NOUN
bam-9610	202	8	,	,	PUNCT
bam-9610	202	9	cox	cox	PROPN
bam-9610	202	10	tm	tm	PROPN
bam-9610	202	11	,	,	PUNCT
bam-9610	202	12	roos	roos	PROPN
bam-9610	202	13	jc	jc	PROPN
bam-9610	202	14	.	.	PROPN
bam-9610	202	15	limits	limit	VERB
bam-9610	202	16	on	on	ADP
bam-9610	202	17	use	use	NOUN
bam-9610	202	18	of	of	ADP
bam-9610	202	19	health	health	NOUN
bam-9610	202	20	economic	economic	ADJ
bam-9610	202	21	assessments	assessment	NOUN
bam-9610	202	22	for	for	ADP
bam-9610	202	23	rare	rare	ADJ
bam-9610	202	24	diseases	disease	NOUN
bam-9610	202	25	.	.	PUNCT
bam-9610	203	1	qjm	qjm	INTJ
bam-9610	203	2	.	.	PUNCT
bam-9610	204	1	2014	2014	NUM
bam-9610	204	2	mar;107(3):241	mar;107(3):241	NOUN
bam-9610	204	3	-	-	PUNCT
bam-9610	204	4	5	5	NUM
bam-9610	204	5	.	.	PUNCT
bam-9610	204	6	doi	doi	NOUN
bam-9610	204	7	:	:	PUNCT
bam-9610	204	8	10.1093	10.1093	NUM
bam-9610	204	9	/	/	SYM
bam-9610	204	10	qjmed	qjme	VERB
bam-9610	204	11	/	/	SYM
bam-9610	204	12	hcu016	hcu016	PROPN
bam-9610	204	13	.	.	PUNCT
bam-9610	205	1	epub	epub	PROPN
bam-9610	205	2	2014	2014	NUM
bam-9610	205	3	jan	jan	PROPN
bam-9610	205	4	22	22	NUM
bam-9610	205	5	.	.	PUNCT
bam-9610	206	1	16	16	NUM
bam-9610	206	2	.	.	PUNCT
bam-9610	207	1	kontoghiorghe	kontoghiorghe	PROPN
bam-9610	207	2	cn	cn	PROPN
bam-9610	207	3	,	,	PUNCT
bam-9610	207	4	andreou	andreou	NOUN
bam-9610	207	5	n	n	CCONJ
bam-9610	207	6	,	,	PUNCT
bam-9610	207	7	constantinou	constantinou	PROPN
bam-9610	207	8	k	k	PROPN
bam-9610	207	9	,	,	PUNCT
bam-9610	207	10	kontoghiorghes	kontoghiorghe	VERB
bam-9610	207	11	gj	gj	PROPN
bam-9610	207	12	.	.	PUNCT
bam-9610	207	13	world	world	PROPN
bam-9610	207	14	health	health	NOUN
bam-9610	207	15	dilemmas	dilemma	NOUN
bam-9610	207	16	:	:	PUNCT
bam-9610	207	17	orphan	orphan	NOUN
bam-9610	207	18	and	and	CCONJ
bam-9610	207	19	rare	rare	ADJ
bam-9610	207	20	diseases	disease	NOUN
bam-9610	207	21	,	,	PUNCT
bam-9610	207	22	orphan	orphan	NOUN
bam-9610	207	23	drugs	drug	NOUN
bam-9610	207	24	and	and	CCONJ
bam-9610	207	25	orphan	orphan	NOUN
bam-9610	207	26	patients	patient	NOUN
bam-9610	207	27	.	.	PUNCT
bam-9610	208	1	world	world	PROPN
bam-9610	208	2	j	j	PROPN
bam-9610	208	3	methodol	methodol	PROPN
bam-9610	208	4	.	.	PUNCT
bam-9610	209	1	2014	2014	NUM
bam-9610	209	2	sep	sep	PROPN
bam-9610	209	3	26;4(3):16388	26;4(3):16388	NUM
bam-9610	209	4	.	.	PUNCT
bam-9610	210	1	doi	doi	NOUN
bam-9610	210	2	:	:	PUNCT
bam-9610	210	3	10.5662	10.5662	NUM
bam-9610	210	4	/	/	SYM
bam-9610	210	5	wjm.v4.i3.163	wjm.v4.i3.163	PROPN
bam-9610	210	6	.	.	PUNCT
bam-9610	211	1	17	17	NUM
bam-9610	211	2	.	.	X
bam-9610	211	3	institute	institute	PROPN
bam-9610	211	4	of	of	ADP
bam-9610	211	5	medicine	medicine	PROPN
bam-9610	211	6	(	(	PUNCT
bam-9610	211	7	us	us	PROPN
bam-9610	211	8	)	)	PUNCT
bam-9610	211	9	committee	committee	NOUN
bam-9610	211	10	on	on	ADP
bam-9610	211	11	accelerating	accelerate	VERB
bam-9610	211	12	rare	rare	ADJ
bam-9610	211	13	diseases	disease	NOUN
bam-9610	211	14	research	research	NOUN
bam-9610	211	15	and	and	CCONJ
bam-9610	211	16	orphan	orphan	NOUN
bam-9610	211	17	product	product	NOUN
bam-9610	211	18	development	development	NOUN
bam-9610	211	19	.	.	PUNCT
bam-9610	212	1	rare	rare	ADJ
bam-9610	212	2	diseases	disease	NOUN
bam-9610	212	3	and	and	CCONJ
bam-9610	212	4	orphan	orphan	NOUN
bam-9610	212	5	products	product	NOUN
bam-9610	212	6	:	:	PUNCT
bam-9610	212	7	accelerating	accelerate	VERB
bam-9610	212	8	research	research	NOUN
bam-9610	212	9	and	and	CCONJ
bam-9610	212	10	development	development	NOUN
bam-9610	212	11	.	.	PUNCT
bam-9610	213	1	field	field	PROPN
bam-9610	213	2	mj	mj	PROPN
bam-9610	213	3	,	,	PUNCT
bam-9610	213	4	boat	boat	NOUN
bam-9610	213	5	tf	tf	NOUN
bam-9610	213	6	,	,	PUNCT
bam-9610	213	7	editors	editor	NOUN
bam-9610	213	8	.	.	PUNCT
bam-9610	214	1	washington	washington	PROPN
bam-9610	214	2	(	(	PUNCT
bam-9610	214	3	dc	dc	PROPN
bam-9610	214	4	):	):	PUNCT
bam-9610	214	5	national	national	PROPN
bam-9610	214	6	academies	academies	PROPN
bam-9610	214	7	press	press	PROPN
bam-9610	214	8	(	(	PUNCT
bam-9610	214	9	us	us	PROPN
bam-9610	214	10	)	)	PUNCT
bam-9610	214	11	;	;	PUNCT
bam-9610	214	12	2010	2010	NUM
bam-9610	214	13	.	.	PUNCT
bam-9610	215	1	pmid	pmid	NOUN
bam-9610	215	2	:	:	PUNCT
bam-9610	215	3	21796826	21796826	NUM
bam-9610	215	4	.	.	PUNCT
bam-9610	216	1	submission	submission	NOUN
bam-9610	216	2	:	:	PUNCT
bam-9610	216	3	january	january	PROPN
bam-9610	216	4	15	15	NUM
bam-9610	216	5	,	,	PUNCT
bam-9610	216	6	2021	2021	NUM
bam-9610	216	7	revision	revision	NOUN
bam-9610	216	8	received	receive	VERB
bam-9610	216	9	:	:	PUNCT
bam-9610	216	10	march	march	PROPN
bam-9610	216	11	2	2	NUM
bam-9610	216	12	,	,	PUNCT
bam-9610	216	13	2021	2021	NUM
bam-9610	216	14	accepted	accept	VERB
bam-9610	216	15	for	for	ADP
bam-9610	216	16	publication	publication	NOUN
bam-9610	216	17	:	:	PUNCT
bam-9610	216	18	march	march	PROPN
bam-9610	216	19	3	3	NUM
bam-9610	216	20	,	,	PUNCT
bam-9610	216	21	2021	2021	NUM
bam-9610	216	22	https://www.who.int/healthinfo/global_burden_disease/globaldaly_method_2000_2016.pdf	https://www.who.int/healthinfo/global_burden_disease/globaldaly_method_2000_2016.pdf	AUX
bam-9610	216	23	https://www.who.int/healthinfo/global_burden_disease/globaldaly_method_2000_2016.pdf	https://www.who.int/healthinfo/global_burden_disease/globaldaly_method_2000_2016.pdf	VERB
bam-9610	216	24	the	the	DET
bam-9610	216	25	global	global	ADJ
bam-9610	216	26	burden	burden	NOUN
bam-9610	216	27	of	of	ADP
bam-9610	216	28	disease	disease	NOUN