 Nurses workload, job stress and shift work disorders Eur J Transl Myol 33 (1) 10909, 2023 doi: 10.4081/ejtm.2023.10909 - 1 - Effects of workload and job stress on the shift work disorders among nurses: PLS SEM modeling Keivan Saedpanah (1), Mohammad Ghasemi (1), Hesam Akbari (1), Amir Adibzadeh (2), Hamed Akbari (1) (1) Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran; (2) Department of Environmental Health Engineering, School of Public Health, Baqiyatallah University of Medical Sciences, Tehran, Iran. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (CC BY-NC 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Abstract Nurses, as the largest forces in the health system, are always challenged with various work responsibilities such as long working hours, lack of manpower and death of patients. This study aimed at providing a model of the relationship between workload and physical and mental health, sleep disorders, and individual and family problems by the mediation role of job stress. The present study is a cross-sectional study that was conducted on 300 nurses in a specialty and sub-specialty hospital in Tehran. For this reason, various questionnaires including demographic, survey of shift workers (SOS) and job stress questionnaires were used to collect the desired data. The proposed model was presented using structural equation modeling method based on Smart-PLS and SPSS-20 software. The results show that workload has an effect on job stress (β=0.747), mental health (β=-0.291), Physical health (β=-0.253), sleep quality (β=-0.234) and personal and family problems (β=-0.206). Also the results of this study show that job stress has an effect on mental health (β=-0.295), Physical health (β=-0.349), sleep quality (β=-0.295) and Personal and family problems (β=-0.441). In conclusion, results showed that the data fitted well with the model and that workload is associated with physical and mental problems, sleep disorders and individual and family problems both directly and indirectly through job stress mediation. Key words:Shift work; workload; job stress; shift disorders. Eur J Transl Myol 33 (1) 10909 2023 doi: 10.4081/ejtm.2023.10909 Providing 24-h services is an inevitable part of the health care system which has led to the introduction of the shift work phenomenon.1 Shift work is a continuous or non-continuous rotational pattern during the day or week and refers to anything that is done outside the time period of 7 am to 6 pm.2 In developed countries, about 20% of the workforce works in shifts, and one third of the workforce work night shifts.3 Shift work is one of the most important challenges of the health system, and nurses as the main force of this system face many complications caused by work shifts.4,5 Long and non-standard working hours, lack of manpower and work shifts caused increased work accidents and human errors, anxiety, sleep disorders, increased smoking, decreased immune function, digestive problems, cardiovascular disease, and musculoskeletal complications.6-8 The workload of a nurse is defined based on the number of patients, workplace situation and facilities, and their performance in providing services,9,10 which includes the qualitative and quantitative workload. The quantitative workload refers to a condition in which individuals are required to perform more tasks that are higher than their capacity.11 A sharp increase in workload can results in several physical and mental consequences for nurses.12 Job stress is considered as one of the most important consequences of long working hours and work over- load in nurses.13 It is defined as an unfavorable mental state in response to workplace pressure.14 According to the National Institute for Occupational Safety & Health (NIOSH) definition, when there is no harmony between job needs and abilities, capabilities and desires, a person experiences job stress.15 Therefore, job stress is associated with the imbalance between a person's capacity and the job tasks.16,17 Researches have shown that workload, as one of the most important causes of job stress, endangers the physical and mental health of nurses.12,18 In this regard, in Shaw et al. study,11 it was found that the qualitative Non -co mmerc ial us e o nly Nurses workload, job stress and shift work disorders Eur J Transl Myol 33 (1) 10909, 2023 doi: 10.4081/ejtm.2023.10909 - 2 - workload could increase stress, anxiety, and depression, however, this association was not significant. Angermeyer et al. reported that nurses are always in the process of stress and psychological damage due to the workload and shift work.19 Numerous stressors can lead to job stress for nurses, such as work over-load, lack of manpower, low freedom of action, patient death, sleep disturbance, long working hours and suffering of patients, physical injuries such as cardiovascular, gastrointestinal and musculoskeletal disorders and individual and family problems.5,20-25 On the other hand, it can be stated that the shift work-related problems are attributed to their job stress. Previous studies have demonstrated that job stress can negatively affect nurses' performance.18,26,27Therefore, the conceptual model of this study is in accordance to the importance of shift problems and nurses' physical and mental health, considering that job stress can act as a mediator between shift work and its complications. Until now, few studies have focused on investigation of stress as a mediator to shift work and its complications. No model- based study has investigated the effect of such variables in Iran. Therefore, the present study aimed to design and present a conceptual model on the effects of workload and job stress on the shift work disorders among nurses. For this reason, the workload was considered as an independent variable, physical health, mental health, sleep quality, individual problems, and family problems were considered as the dependent variables. The job stress was considered as a mediator variable. Figure 1 shows the proposed conceptual model of this study. Materials and Methods The aim of this study was to present a conceptual model through structural equation modeling in 2021. The research population included all nurse staffs in a specialty and sub-specialty hospital in Tehran. According to the statistics provided by vice- chancellorship for treatment, the total number of employed nurses in this hospital was estimated to be about 1000 individuals. Based on Krejcie and Morgan's Table according to Osipow,28 278 individuals were selected, and finally, 310 individuals were selected as the study population considering 10% of the possible fall. Inclusion criteria included having at least a bachelor's degree, at least one year of work experience and not having a second job. Moreover, the nurses with a history of severe personal stress and those who did not tend to cooperate in the study were excluded from the study. Finally, 300 questionnaires were analyzed. The protocol of the present study was approved by the Baqiyatallah University of Medical Sciences. The stratified random sampling was used for collecting the samples. In this study, various questionnaires were used for collecting the data including demographic characteristic, job stress and survey of shift workers (SOS) questionnaires. Demographic questionnaire consisted of questions regarding demographic variables such as gender, age, level of education, and work experience. Osipow Occupational Stress Inventory was developed in 1987 by Osipow et al.28 to assess individual stress in six dimensions including role overload, role insufficiency, role ambiguity, role boundary, role responsibility and work environment. This questionnaire consisted of 60 questions, which Table 1. Scale of Osipow questionnaire based on gender Questionnaire Score Stress Level Male Female 60-133 60-107 No Stress 134-216 108-203 Normal 217-258 204-251 Medium 259-300 252-300 Severe Fig 1. The proposed conceptual model Non -co mmerc ial us e o nly Nurses workload, job stress and shift work disorders Eur J Transl Myol 33 (1) 10909, 2023 doi: 10.4081/ejtm.2023.10909 - 3 - each of them are assessed using 10 questions. The scoring of this questionnaire is based on the Likert scale which includes never (number1) to most of the time (number 5). Some of the questions in this questionnaire have a reverse scoring range. This questionnaire measures the stress level of individuals based on their gender. The scale of assessment based on gender is presented in Table 1. This questionnaire was calculated by 89% in Iranian society by Komeili-Sani et al. using Cronbach's alpha coefficient.29 The SOS questionnaire was first introduced by Barton et al. based on the standard shift work index.30 This questionnaire has three sections of general information, individual differences and tolerance of shift work, and consists of questions related to the population and individual characteristics (11 questions), type of shift system (3 questions), job satisfaction (5 questions), mental - psychological problems (10 questions), gastrointestinal problems (8 questions), cardiovascular problems (5 questions), sleep disturbances (4 questions), musculoskeletal disorders (4 questions), and the adverse effects of shift work on individual and family life (4 questions). Scoring of this questionnaire is graded as a 4-point Likert scale from never (1 point) to always (4). The validity of this questionnaire was confirmed by Choobineh et al. using content and structural validity.31 Kuder-Richardson method was also used for the reliability, which was obtained to be about 81%.30 Pordanjani et al. determined the reliability of this questionnaire using Cronbach's alpha coefficient, which was calculated to be 0.67, 0.86, 0.87, 0.85, 0.79 and 0.87 for workload, cardiovascular, gastrointestinal, musculoskeletal, general health and sleep disorders, respectively.31Preliminary analyses such as mean, standard deviation and data normality test were performed using SPSS software. Then, the validity analysis of the variables was observed using Smart-PLS software, and finally, the research hypotheses were examined according to the research objectives using the Structural Equation Modeling (SEM) and given to the results of path coefficients.32 SEM is a method of multivariate statistical analysis and a combination of factor analysis, path analysis and regression, and is a comprehensive statistical approach to identify hidden variables related to an index.33 In order to evaluate the normality of the variables distribution, kurtosis and skewness tests were used. The measurement model was evaluated in two stages using first-order confirmatory factor analysis and second-order confirmatory factor analysis. Cronbach's alpha (α) and composite reliability (CR) were used to evaluate the reliability. Finally, two criteria of convergent validity and divergent validity were used to evaluate the validity of the model. In order to evaluate the convergent and divergent validity, the extracted mean variance index and Fornell-Larcker and HTMT ratio methods were used, respectively. Results The study population consisted of 300 nurses from a specialty and sub-specialty hospital in Tehran. Of them, 61.3% were female and 38.7% male. Most participants (30.3%) were in the age range 25-35 years. Table 2 shows that 215 participants had a bachelor's degree and 85 had a postgraduate degree. Therefore, most of the participants in this project (71.6%) had a bachelor's degree. Table 2 presents the demographic variables. As all statistical tests, the normality of the variables distribution should be tested in SEM.34 In this study, kurtosis and skewness test were used to investigate the claim about the distribution of a quantitative variable data. According to the suggestion of George and Mahler,35 the acceptable range of skewness and kurtosis is +2 and -2. The results showed that the amount of skewness and kurtosis of all items was in the range of +2 and -2. Therefore, no violation of data normality was observed, As a result, it can be stated that all items were normal. The measurement model was evaluated in two steps. In the first stage, the results of the first-order confirmatory factor analysis were performed for all research items and related variables, and in the second stage, second-order confirmatory factor analysis was performed due to the fact that the variables of job stress, mental and physical health have dimensions. Factor loading coefficients of items (questions) are the first factor to be considered in reflective models. According to Chin,34 the standardized factor loading of each item should be greater than 0.5; at this stage, two indices of Cronbach's alpha coefficient (α) and composite reliability criterion (CR) were used to evaluate the reliability of the research items, in which Table 2. Results of descriptive statistics of demographic variables Frequency Number Item Variable 38.7 116 Male Gender 61.3 184 Female 29.0 87 < 25 Age 30.3 91 25-35 27.7 83 36-45 13.0 39 >45 71.6 215 Under graduate Educationnel Level 28.3 85 Graduate 41.7 125 < 10 Work Exprience 47.7 143 10-20 10.7 32 > 20 Non -co mmerc ial us e o nly Nurses workload, job stress and shift work disorders Eur J Transl Myol 33 (1) 10909, 2023 doi: 10.4081/ejtm.2023.10909 - 4 - values above 0.7 are acceptable for the reliability of the measurement model.35 To evaluate the validity of the model, two criteria of convergent validity and divergent validity were used. In order to evaluate the convergent validity, the extracted mean variance index (2) was used, which should ≥0.5 according to Fornell-Larcker.36 In order to evaluate the divergent validity, Fornell- Larcker and HTMT ratio methods were used. The results showed that the values of all factor loadings are greater than 0.5 and the observable variables are a reliable scale for calculating the latent variables of the model. Table 3 shows the fitting results of the proposed conceptual model. According to Table 3, CR results were between 0.934 and 0.969, which showed that CR obtained for all variables was higher than 0.7, which is acceptable.35 Cronbach's alpha results showed that the values of all variables are higher than 0.7. All extracted mean variances are greater than 0.5, and between 0.590 and 0.756, indicating that convergent validity is confirmed Table 3. Results of factor loadings and convergent validity and reliability coefficients Extracted Mean variance CR Cronbach's alpha (α) Main variables (latent) 0.733 0.965 0.965 Loading role O ccupational Stress Inventory 0.69 0.956 0.955 Insufficiency role 0.756 0.969 0.969 Ambiguity role 0.697 0.958 0.959 Boundary role 0.697 0.958 0.957 Responsibility 0.59 0.934 0.936 Physical environment 0.658 0.938 0.937 Physical symptoms survey of shift w orkers questionnaire 0.701 0.942 0.942 Social function 0.947 0.72 0.947 Anxiety symptoms 0.605 0.914 0.914 Depression Symptoms 0.704 0.905 0.905 Cardiovascular complications 0.779 0.934 0.934 Skeletal and muscular complications 1 1 1 Gastrointestinal complications 0.665 0.856 0.856 Workload 0.706 0.827 0.823 sleep quality 0.751 0.900 0.900 Individual and family problems Table 4. Divergent validity matrix by Fornell -Locker method (second order structure) Workload Mental health Sleep quality Individual and family problems Physical health Job stress variables 0.784 Job stress 0.794 -0.538 Physical health 0.866 0.298 -0.594 Individual and family problems 0.84 0.347 0.462 -0.47 Sleep quality 0.771 0.428 0.304 0.385 -0.513 Mental health 0.815 -0.511 -0.455 -0.535 -0.514 0.747 Workload Non -co mmerc ial us e o nly Nurses workload, job stress and shift work disorders Eur J Transl Myol 33 (1) 10909, 2023 doi: 10.4081/ejtm.2023.10909 - 5 - for the variables in this study. According to the above results, it can be stated that the convergent reliability and validity of all variables are acceptable. For divergent validity, Fornell-Larcker and HTMT ratio methods were used. In Fornell-Larcker method, the relationship between the extracted squares of variance and the mean correlation was used to show the divergent validity. According to Fornell-Larcker, the extracted square of variance should be greater than the mean correlation of the variables. HTMT criterion measures the ratio of multiple attributes of observed variables to their single attributes. If this ratio is less than 0.9, the measurement model has validity conditions. Table 4 shows the divergent validity matrix by Fornell-Locker method. The correlation between the structures is less than the mean square of the extracted variance of each structure, which shows that no two variables are completely correlated with each other. The composition of the items indicates that the structures are well separated from each other. Therefore, the measurement tool has a divergent validity. Table 5 shows the results of HTMT index survey. All values are less than 0.9 and show that the measurement tool is divergent according to this criterion.37 The evaluation results of the second-order measurement model are shown in Figure 2. According to Table 6, the Table 5. Divergent validity matrix using HTMT index method (second order structure) Mental health Sleep quality Individual and family problems Physical health Job stress Variables Job stress 0.538 Physical health 0.299 0.588 Individual and family problems 0.346 0.498 0.469 Sleep quality 0.433 0.308 0.412 0.512 Mental health 0.512 0.456 0.536 0.522 0.737 Workload Fig 2. Evaluation of the measurement model (second order). Non -co mmerc ial us e o nly Nurses workload, job stress and shift work disorders Eur J Transl Myol 33 (1) 10909, 2023 doi: 10.4081/ejtm.2023.10909 - 6 - values of R2 are calculated for the endogenous structures of the research and confirm the suitability of the structural model fitting according to the criterion value. According to Cohen,38 three values of 0.02, 0.16 and 0.26 are considered as the criterion values for weak, medium and strong. Therefore, the effect of independent variables on the dependent variables of this research was desirable and strong. In this study, in order to evaluate the quality or validity of the model, the validity index of redundancy was used. According to Table 6, the redundancy index for all endogenous variables was more than zero, so it can be concluded that the structural model of this study has the appropriate predictive power for endogenous variables. The effect size criterion (f2), introduced by Cohen,38 determines the intensity of the relationship between model structures. The effect size criterion uses R2 index to analyze the relationship between structures. The values of 0.02, 0.15 and 0.35 indicate the small, medium and large effect size of one structure on another, respectively. According to the mentioned values, the effect of workload on job stress, mental health, physical health, sleep quality and individual and family problems are equal to 1.261, 0.053, 0.042, 0.32 and 0.30, respectively. The effect size of workload on job stress is "large" and on other quality-dependent variables is "small". The effect of job stress on mental health, physical health, sleep quality and individual and family problems were 0.055, 0.079, 0.051 and 0.137, respectively. The effect size of job stress on the variables depended to this variable was "small". In this study, the relevant hypotheses were tested based on bootstrap (value 10,000). The level of error defined in this study was obtained to be 0.05, and t-value was higher than 1.96, indicating the hypothesis acceptance. The final model is shown in Figure 3. The investigation of the results of testing the hypotheses showed that the path of "workload to job stress" was significant at the level of 0.01 and the critical value of 14.428. The amount of factor loading was equal to 0.747. According to the obtained values, the hypothesis that "workload has an effect on job stress" was confirmed. The results of the path "workload to mental health" showed that the p-value was less than 0.05, and also the critical ratio value (2.251) for this path was more than 1.96. So, the effect of workload on mental health was significant at the level of 95%. It should be noted that the open value of the standardized factor for Table 6. Results of determination coefficient of R2 and redundancy validity (CV Red) Redundancy validity (CV Red) Determination coefficient of R2 Endogenous latent variables 0.283 0.558 Job stress 0.182 0.318 Physical health 0.258 0.372 Individual and family problems 0.153 0.245 Sleep quality 0.161 0.300 Mental health Table 7. Effect size results (f2) The effect size criterion (f2) Path 1.261 Workload->job stress 0.053 Workload->mental health 0.042 Workload->physical health 0.032 Workload->sleep quality 0.030 Workload-> individual& family problems 0.055 Job stress->mental health 0.079 Job stress-> physical health 0.051 Job stress-> sleep quality 0.137 Job stress-> individual & family problems Non -co mmerc ial us e o nly Nurses workload, job stress and shift work disorders Eur J Transl Myol 33 (1) 10909, 2023 doi: 10.4081/ejtm.2023.10909 - 7 - this path was 1.291, which indicated the effect of workload on mental health. The results showed that the path of "workload to physical health" was significant at the level of 95% (significant value was equal to 0.014 and < 0.05) and the amount of standardized factor loading (-0.253) for this path showed the negative impact of "workload" on "physical health". The results confirmed the hypothesis that "workload has an effect on physical health". In relation to the hypothesis of “workload to sleep quality”, given that p-value was less than 0.05, it can be claimed that this hypothesis is confirmed by an error coefficient of 5%. Therefore, it can be claimed that workload affects the sleep quality. The results showed that the path of "workload to individual and family problems" was significant at the level of 95% (significant value is equal to 0.038 and less than 0.05), and the amount of standardized factor loading (-0.206) for this path shows the negative impact of "workload" on "individual and family problems". The results confirm the hypothesis that "workload has an effect on physical health". The results of the path of "job stress on mental health" show that p-value is less than 0.01 and the value of the critical ratio (2.670) for this path is more than 1.96, which indicates the effect of job stress on mental health is significant at 99%. The relationship between job stress and physical health was calculated to be equal to -0.349, and the critical ratio value was 3.534, which was greater than t-critical value (1.96) and shows that the observed relationship is significant. Therefore, it can be said that job stress affects physical health by a confidence level of 95%. The results of the path of “job stress to sleep quality” showed that the standardized factor loading for this path was -0.295 and the significance level was equal to 0.0011, which was less than 0.05. According to the results, the hypothesis that "Job stress has an effect on sleep quality" was confirmed at a confidence level of 95%. The results of the hypothesis that job stress affects individual and family problems showed that p-value was less than 0.001, which confirmed the hypothesis by 1% level. The results of hypothesis testing are shown in Table 8. Discussion The aim of this study was to present a model of the workload and job stress effect on shift work-related disorders in nurses. The proposed model provided an appropriate summary of the research background about the mediation role of job stress and shift work complications that can be used in future studies. The Fig 3. Evaluation of the measurement model (second order) Non -co mmerc ial us e o nly Nurses workload, job stress and shift work disorders Eur J Transl Myol 33 (1) 10909, 2023 doi: 10.4081/ejtm.2023.10909 - 8 - overall results of the conceptual model showed that the proposed model had acceptable convergent and divergent validity and reliability, so it had sufficient credibility. The calculated R2 values for the endogenous structures of the research confirmed the proposed conceptual model fitting. The effect of independent variables on the dependent variables of this research was estimated to be desirable and strong. Finally, the redundancy index was used to check the validity of the model, which showed that the proposed model had a good predictive power for endogenous variables. The results of the model evaluation showed that workload both directly and indirectly has an effect on physical and mental health, sleep quality and individual and family problems through job stress mediation. Work over-load, lack of manpower, low freedom of action, long working hours always cause stress and fatigue in nurses and endanger their physical health. Previous studies have shown that work over-load is the main cause of job stress.39-41 The results of the present study showed that workload and job stress can endanger people's physical health. Accordance to the results of this study, other studies have shown that job stress along with a work over-load acts as an important factor in reducing the life quality of nurses and creating health problems for them. It has been also reported that stress is significantly associated with many physical problems such as migraine, muscle pain, back and joints pain, hypertension, acute myocardial infarction, irritable bowel syndrome, duodenal ulcer, immune system and endocrine diseases. Quantitative and qualitative work overload can lead to physiological changes, increased blood cholesterol and increased heart beat.42-46 The conceptual model of the present study demonstrated that workload and job stress increase people's mental health problems and disorders. In accordance with the present study, the results of other studies also showed a significant relationship between stress levels and psychological problems such as anxiety, low self- esteem, depression and feelings of inadequacy.47-50 In another study, the researchers stated that the quantitative workload is an external factor imposed on people through the work environment and cannot lead to psychological problems; however, it leads to time limitation and mental pressure in the person. While the qualitative workload has an internal and mentality aspect in which the person does not see himself adequate and suitable for his job and this feeling of inadequacy leads to depression, hostility, anxiety and job stress.11 The results of the present study indicated that workload directly or indirectly leads to sleep disorders in nurses through the mediation role of job stress. Previous studies have shown that workload had a direct negative effect on sleep quality.5,11,13,20 Moreover, several studies have reported that work over-load had a negative effect on sleep by increasing job stress leading to suppression Table 8. Hypothesis test results Conclusion Significan ce level Critical value (t) Coefficient of path (β) Path Hypothes is Significant 0.001 14.428 0.747 Workload->job stress 1 Significant 0.024 2.251 -0.291 Workload->mental health 2 Significant 0.014 2.446 -0.253 Workload- >physicalhealth 3 Significant 0.041 2.044 -0.234 Workload- >sleepquality 4 Significant 0.038 2.073 -0.206 Workload- >individual&familypro blems 5 Significant 0.008 2.67 -0.295 Job stress->mental health 6 Significant 0.001 3.534 -0.349 Job stress- >physicalhealth 7 Significant 0.011 2.545 -0.295 Job stress-> sleep quality 8 Significant 0.001 4.823 -0.441 Job stress-> individual & family problems 9 Non -co mmerc ial us e o nly Nurses workload, job stress and shift work disorders Eur J Transl Myol 33 (1) 10909, 2023 doi: 10.4081/ejtm.2023.10909 - 9 - of sleepiness, sleep related respiratory disorders, lack of sleep and reduced sleep hours.32 Shift work is an integral part of the health system and poses many complications to nurses. It is noteworthy that effective strategies can be used to reduce job stress, and consequently mental and physical disorders, sleep disorders, and individual and family life problems in nurses. Since the sampling was performed during COVID 19 pandemic, the nurses possibly were affected by the disease, and hence more extensive and detailed studies are needed to confirm our findings. One of the most important limitations of this study was the lack of generalizability of its results to all healthcare workers due to the use of information from only one hospital, and it is necessary to conduct this study in other hospitals with a larger population. In general, the results of the present study show that job stress caused by work over-load among nurses can lead to physical and mental health problems, sleep disorders and individual and family problems. Therefore, in order to minimize the medical errors and accidents, to improve the health and safety of nurses, the economic and productivity of the health system, more studies are required to be conducted on control job stress and its complications in nurses. List of acronyms CR - composite reliability f2 - effect size criterion R2 - size criterion uses SEM - Structural Equation Modeling SOS - survey of shift workers Contributions of Authors The authors have all read and approved the final manuscript, and were all involved in the methodology design, data analysis, literature review and manuscript preparation. Acknowledgments The authors would like to state their gratitude to all the nurses who participated in this study. We would like to thanks the valuable tips and advice of the Clinical Research Development Unit of Baqiyatallah Hospital (Ethics code: IR.BMSU.REC.1399.258, project code: 98000079). Funding The authors received no specific funding for this work. Conflict of Interest Conflicts of Interest: The authors declare that there are no conflicts of interest regarding this research. Ethical Publication Statement We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Corresponding Author Hamed Akbari, Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. ORCID ID: 0000-0003-3284-6329 E-mail: ha.akbari727@gmail.com or akbarihamed_2005@yahoo.com E-mails and ORCID iD of co-authors KeivanSaedpanah: Keivan.Saedpanah@gmail.com ORCID iD: 0000-0001-6111-0471 Mohammad Ghasemi:mghmed@yahoo.com ORCID iD:0000-0002-8254-8701 HesamAkbari: hesam120@yahoo.com ORCID iD:0000-0003-1668-477X Amir Adibzadeh: adibzadeh_251@yahoo.com ORCID iD:0000-0002-5703-0759 References 1. Moreno CR, Louzada FM. What happens to the body when one works at night? 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Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. Submission:October 5, 2022 Revision received: October 31, 2022 Accepted for publication: October 31, 2022 Non -co mmerc ial us e o nly