Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
Eur J Transl Myol 33 (1) 2023 11279. doi: 10.4081/ejtm.2023.11279 

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Last-minute abstracts of 2023 Padua Days of Muscle and Mobility 
Medicine (2023 Pdm3) and 2023 Editorial board of EJTM  
Sandra Zampieri (1,2,3,4), Ugo Carraro (2,3,4) 

(1) Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua,
Italy; (2) Department of Biomedical Sciences, University of Padua, Italy; (3) CIR MYO -
Interdepartmental Research Centre of Myology, University of Padua, Italy; (4) Armando &
Carmela Mioni-Carraro Foundation for Translational Myology, Padua, Italy.
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (CC BY-NC 4.0) which permits 
any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. 

Abstract 

The 2023 Padua Days of Muscle and Mobility Medicine (Pdm3) are scheduled from March 29th 

to April 1st, 2023. The abstracts collected during autumn and early winter of 2022 were e-
published in the issue 33 (1) 2023 of the European Journal of Translational Myology (EJTM). 
Now the last-minute abstracts are reported here (100 Oral presentations are listed in the final 
Program). All together they confirm the interest of very different international specialists, filling 
the four days of 2023Pdm3. Indeed, scientists and clinicians from Austria, Bulgaria, Canada, 
Denmark, France, Georgia, Germany, Iceland, Ireland, Italy, Mongolia, Norway, Russia, 
Slovakia, Slovenia, Spain, Switzerland, The Netherlands and USA will gather to the Hotel 
Petrarca of Thermae of Euganean Hills, Padua, Italy. The apparent heterogeneity of the 
specialists, collectively raccolti under the umbrella of the Mobility Medicine neologism is 
stressed by the need to extend the Sections of the 2023 Editorial Borad of EJTM also here 
reported. We hope that Speakers of the 2023 Pdm3 and readers of EJTM will submit 
“Communications” to the European Journal of Translational Myology by May 20, 2023 and/or 
to the 2023 Special Issue: “Pdm3” of the Journal Diagnostics, MDPI, Basel, Switzerland with 
deadline September 30, 2023. See you soon at the Hotel Petrarca of Montegrotto Terme, Padua, 
Italy. For a promo of the 2023 Pdm3 link to: 
https://www.youtube.com/watch?v=zC02D4uPWRg  
Key Words: Padua Days of Muscle and Mobility Medicine (Pdm3); last minute abstract; 
European Journal of Translational Myology and Mobility Medicine, PAGEpress, Pavia, Italy; 
Diagnostics, MDPI, Basel. 

Eur J Transl Myol 33 (1) 11279. doi: 10.4081/ejtm.2023.11279

 The Padua Muscle Days (PMDs), i.e., meetings of
biology, physiology, medicine and rehabilitation of 
skeletal muscle started more than 30 years ago, precisely 
to provide advice on Translational Myology. Recently 
the interests broadened to complementary disciplines and 
neologisms were found necessary, specifically Mobility 
Medicine and the Padua Days of Muscle and Mobility 
Medicine (Pdm3). Despite the worsening evolution of the 
East-Europe crisis, the program of the 2023 Pdm3 was 
confirmed in autumn 2022 with Scientific Sessions to 
occur over four full days at either the Guariento Hall of 
the Galilean Academy of Arts, Letters and Sciences of 
Padua (March 29, 2023) and then in the Conference Hall 
of the Hotel Petrarca, Thermae of Euganean Hills 
(Padua), Italy. Collected during fall 2022, the titles and 
abstracts of approximately 90 oral presentations were 

listed in evolving preliminary schedules.1 Here we add 10 
last-minute Abstracts, bringing the final Program to 100 
Oral Presentations. The four days of 2023 Pdm3 will 
include senior and junior scientists and clinicians from 
Austria, Bulgaria, Canada, Denmark, France, Georgia, 
Germany, Iceland, Ireland, Italy, Mongolia, Norway, 
Russia, Slovakia, Slovenia, Spain, Switzerland, The 
Netherlands and USA. Together with the Final 
Programme, the two Collections of Abstracts are 
published in electronic format in issue 33 (1) 2023 of the 
European Journal of Translational Myology (EJTM). The 
apparent heterogeneity of the specialists, gathered under 
the umbrella of the neologism Mobility Medicine, is 
underlined by the need to expand the Sections of the 
EJTM 2023 Editorial Board also reported here. In the two 
Complementary Collections some empty Abstracts 

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Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
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appear with only names and affiliations of authors, due to 
the decision of the speakers not to disclose their 
unpublished results. It is a pity that this happens, but in 
the meantime, we stress that those decisions are strong 
evidence of the relevance of the 2023 Pdm3. Readers are 
invited to personally join the Meeting in Padua Galilean 
Academy of Arts, Letters and Sciences and in the 
Conference Hall of the Hotel Petrarca to get a preview of 
the original results of the best laboratories performing 
translational research on muscle and mobility medicine. 
See you in the late afternoon of March 28, 2023 for an 
aperitive at the Hotel Petrarca of Montegrotto Terme, 
Euganean Hills (Padua), Italy. We are confident that the 
2023 Pdm3 will be as interesting as the successful events 
of the last years.2-14  
For a promo of the 2023 Pdm3 link to: 
https://www.youtube.com/watch?v=zC02D4uPWRg  
Finally, we would like to thank those organizers/chairs 
that were more able to attract speakers to the 2023 
Pdma3, specifically: Elisabeth R. Barton, Ines Bersch-
Porada, Paolo Gargiulo, Elena P. Ivanova, Christiaan 
Leeuwenburgh, Marco V. Narici, Riccardo Rosati, Piera 
Smeriglio, Carla Stecco, Daniela Tavian and H. Lee 
Sweeney. 

List of acronyms 
EJTM - European Journal of Translational Myology  
MDPI - Molecular Diversity Preservation International  
Pdm3 - Padua Days on Muscle and Mobility Medicine 
PMD – Padua Muscle Days 

Acknowledgments 
The authors thank Organizers, Chairs, Speakers, and 
Attendees for their scientific and personal financial 
contributions to the success of the Pdm3. 

Funding 
The 2023 Pdm3 are supported by the University of 
Florida Myology Institute and Wellstone Center, 
Gainesville, FL, USA (H. Lee Sweeney, Gainesville, FL, 
USA) and by Physiko- & Rheuma-therapie, Institute for 
Physical Medicine and Rehabilitation, St. Pölten, 
Austria, Centre of Active Ageing - Competence Centre 
for Health, Prevention and Active Ageing, St. Pölten, 
Austria and Ludwig Boltzmann Institute for 
Rehabilitation Research, St. Pölten, Austria (Helmut 
Kern, Wien, Austria).  E-publishing is supported by the 
Armando & Carmela Mioni-Carraro Foundation for 
Translational Myology, Padua, Italy. 

Conflict of Interest  

The authors disclose no conflicts of research and 
publication interest or any specific endorsements of the 
products referenced in this manuscript. 

Ethical Publication Statement 
We confirm that we have read the Journal’s position on 
issues involved in ethical publication and affirm that this 
report is consistent with those guidelines. 

Corresponding Author 
Sandra Zampieri, Department of Surgery, Oncology and 
Gastroenterology, Padova University Hospital, Padua, 
Italy.  
ORCID iD: 0000-0001-6070-0011 
Email: sanzamp@unipd.it 

Emails of Coauthor 
Ugo Carraro: ugo.carraro@unipd.it  
ORCID: 0000-0002-0924-4998 

References 
1. Zampieri S, Stecco C, Narici M, Masiero S, Carraro 

U. 2023 On-site Padua Days on Muscle and Mobiliy 
Medicine: Call for speakers. Eur J Transl Myol. 2022 
Dec 13. doi: 10.4081/ejtm.2022.11071. Online ahead 
of print. PMID: 36511885 Free article. 

2. Carraro U, Bittmann F, Ivanova E, Jónsson H Jr, Kern 
H, Leeuwenburgh C, Mayr W, Scalabrin M, Schaefer 
L, Smeriglio P, Zampieri S. Post-meeting report of 
the 2022 On-site Padua Days on Muscle and Mobility 
Medicine, March 30 - April 3, 2022, Padua, Italy. Eur 
J Transl Myol. 2022 Apr 13;32(2):10521. doi: 
10.4081/ejtm.2022.10521. PMID: 35421919; 
PMCID: PMC9295170. 

3. Sweeney HL, Masiero S, Carraro U. The 2022 On-
site Padua Days on Muscle and Mobility Medicine 
hosts the University of Florida Institute of Myology 
and the Wellstone Center, March 30 - April 3, 2022 
at the University of Padua and Thermae of Euganean 
Hills, Padua, Italy: The collection of abstracts. Eur J 
Transl Myol. 2022 Mar 10;32(1):10440. doi: 
10.4081/ejtm.2022.10440. PMID: 35272451; 
PMCID: PMC8992680. 

4. Carraro U, Yablonka-Reuveni Z. Translational 
research on Myology and Mobility Medicine: 2021 
semi-virtual PDM3 from Thermae of Euganean Hills, 
May 26 - 29, 2021. Eur J Transl Myol. 2021 Mar 
18;31(1):9743. doi: 10.4081/ejtm.2021.9743. PMID: 
33733717; PMCID: PMC8056169. 

5. Carraro U. 30 Years of Translational Mobility 
Medicine: 2020 Padua Muscle Days go virtual from 
Euganean Hills, November 19th to 21st. Eur J Transl 
Myol. 2020 Nov 17;30(4):9437. doi: 
10.4081/ejtm.2020.9437. PMID: 33520146; PMCID: 
PMC7844408 

6. Carraro U. Thirty years of translational research in 
Mobility Medicine: Collection of abstracts of the 
2020 Padua Muscle Days. Eur J Transl Myol. 2020 
Apr 1;30(1):8826. doi: 10.4081/ejtm.2019.8826. 
PMID: 32499887; PMCID: PMC7254447 

7. Carraro U. 2019Spring PaduaMuscleDays: 
Translational Myology and Mobility Medicine. Eur J 
Transl Myol. 2019 Feb 21;29(1):8105. doi: 
10.4081/ejtm.2019.8105. PMID: 31019665; PMCID: 
PMC6460213 

8. Carraro U. Exciting perspectives for Translational 
Myology in the Abstracts of the 2018Spring 

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mailto:ugo.carraro@unipd.it


Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
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PaduaMuscleDays: Giovanni Salviati Memorial - 
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PMC6047882. 

9. Carraro U. Exciting perspectives for Translational 
Myology in the Abstracts of the 2018Spring 
PaduaMuscleDays: Giovanni Salviati Memorial - 
Chapter III - Abstracts of March 16, 2018. Eur J 
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PMC6047881. 

10. Carraro U. Exciting perspectives for Translational 
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PaduaMuscleDays: Giovanni Salviati Memorial - 
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PMC6047880. 

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Chapter I - Foreword. Eur J Transl Myol. 2018 Feb 
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29686822; PMCID: PMC5895991. 

12. Carraro U. 2017Spring PaduaMuscleDays, roots and 
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28713538; PMCID: PMC5505085. 

13. Coste CA, Mayr W, Bijak M, Musarò A, Carraro U. 
FES in Europe and Beyond: Current Translational 
Research. Eur J Transl Myol. 2016 Dec 
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28078074; PMCID: PMC5220221. 

14. Carraro U, Coletti D, Kern H. The Ejtm Specials "The 
Long-Term Denervated Muscle". Eur J Transl Myol. 
2014 Mar 27;24(1):3292. doi: 10.4081/ejtm 
.2014.3292. PMID: 26913124; PMCID: 
PMC4749000. 

Disclaimer 
All claims expressed in this article are solely those of the 
authors and do not necessarily represent those of their 
affiliated organizations, or those of the publisher, the 
editors and the reviewers. Any product that may be 
evaluated in this article or claim that may be made by its 
manufacturer is not guaranteed or endorsed by the 
publisher. 
 

Submitted: March 3, 2023 
Accepted for publication: March 3, 2023

 

  
 

  

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European Journal of Translational Myology - eISSN 2037-7460 - ISSN 2037–7452 – BAM On-Line 
   

 

2023 Pdm3, March 29 - April 1, 2023 - Thermae of Euganean Hills, Padua (Italy) 
Galilean Academy of Padua &Thermae of Euganean Hills  (Padua, Italy) 

Hotel Petrarca, Piazza Roma 23, Montegrotto Terme, Euganean Hills, (Padua), 35122 Italy 
Phone +39 049 891 1744 - Email: petrarca@hotelpetrarca.it - https://www.hotelpetrarca.it/ 

 
 
 
 
 
 
 

Organizers: Elisabeth R. Barton, Ines Bersch-Porada, Ugo Carraro, Marcus Coplin, Raffaele De Caro, Paolo Gargiulo, Elena P. 
Ivanova, Helmut Kern, Nathan K. LeBrasseur, Christiaan Leeuwenburgh, Alessandro Martini, Stefano Masiero, Marco V. Narici, 

Rosanna Piccirillo, Riccardo Rosati, Marco Sandri, Piera Smeriglio, Carla Stecco, H. Lee Sweeney, Sandra Zampieri 

WEDNESDAY March 29, 2023  
08:00 AM Complimentary Bus Transfer to Padua 

Guariento Hall, Galilean Academy of Arts and Science of Padua, Italy 

09:00 AM Openings Raffaele De Caro, Marco V. Narici, Ugo Carraro: Greetings and thanks to lecturers, 
speakers, audience and sponsors 

09:20 AM Lecture of Carlo Reggiani, University of Padua, Italy: Single muscle fibers as a tool in 
aging research 

10:00 AM Session I: Adaptations to Physical Exercise in Aging: from cell to functioning 
 Marco V. Narici, Roberto Bottinelli, Chairs 
10:00 AM Russell T. Hepple, University of Florida, USA: Skeletal muscle plasticity to resistance training in pre-

frail/frail elderly women  
10:20 AM Julian Alcázar Caminero, Universidad de Castilla-La Mancha, Toledo, Spain: Improving muscle power 

through exercise in old age 
10:40 AM Simone Porcelli, University of Pavia, Italy: Home-based aerobic exercise training improves skeletal 

muscle oxidative metabolism in old people 
11:00 AM Martino Franchi, University of Padua, Italy: Differential muscle adaptations to concentric and 

eccentric resistance training in older people 
11:20 AM  Marco V. Narici, University of Padua, Italy: The neuroprotective effects of exercise in older age 
11.40 AM Gianni Biolo, University of Trieste, Italy: Nutrient-exercise interaction on muscle mass and function in 

aging 
12:00 AM Maria Chiara Maccarone, Barbara Ravara, Walter Giuriati, Stefano Masiero, Ugo Carraro, University 

of Padua, Italy: Combating muscle weakness in bed-ridden eldery with Home-based Full-Body in-Bed 
Gym (hbFBiBG): Basics, Implementation and Preliminary Results of the Padua Initiative 

12:20 AM Ugo Carraro, University of Padua, Italy: Blood contamination a lucky chance to analyze non-invasively 
Myokines in mouth fluids 

12:30 AM Daniela Tavian, Ester Tommasini, et al., Milan, Italy: Irisin and sarcopenia: salivary irisin is induced by 
strenuous exercise and correlates with circulating irisin 

 
 

12.45 AM  Lunch in Piazza Duomo, Padua, Italy  
 
 

  

Italian Easy Aging and    
A&C M-C Foundation for 
Translational Myology 

 CIR-MYOLOGY 
UNIVERSITY OF PADUA, ITALY  

 
 
 

    

 
 

 
  

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WEDNESDAY March 29, 2023  
Guariento Hall, Galilean Academy of Arts and Sciences of Padua, Italy 

02:00 PM    SESSION II: Skeletal Muscle Epigenetics and the dark side of the genome 
 Piera Smeriglio, Marco Sandri, Chairs 
02:00 PM  Marco Sandri, et al., University of Padua, Italy: Discovering novel longevity genes by looking at the dark 

side of the genome 
02:20 PM Chiara Lanzuolo, National Institute of Molecular Genetics, Milan, Italy: Chromatin conformation of 

muscle stem cells in physiological and pathological muscular aging  
02:40 PM Isabella Scionti, INMG, Lyon, France: Epigenetic modifiers role in modulating muscle stem cell plasticity 
03:00 PM Piera Smeriglio, Sorbonne Université, Paris, France: Understanding epigenetics in spinal muscle atrophy: 

how the yin and yang of genomic regulation contribute to the disease 
03:20 PM Giuseppina Caretti, et al., Milan University, Italy: Epigenetic targeting of BET proteins rewire 

metabolism in the aged skeletal muscle 
03:40 PM Silvere M. van der Maarel, Leiden University Medical Center, The Netherlands: Facioscapulohumeral 

Dystrophy: Incomplete Repression of the Cleavage Stage Transcription Factor DUX4 in Skeletal Muscle 
 

04:00 PM   SESSION III: Adaptations in Aging: from molecules to functioning 
 Amber L. Pond, Rosanna Piccirillo, Chairs 
04:00 PM Amber L. Pond, Southern Illinois University School of Medicine in Carbondale, IL, USA: The HERG K+ 

channel increases intracellular calcium in myotubes by modulation of Calsequestrin 
04:20 PM Hans Hoppeler, University of Bern, Switzerland: Fascia, Facts and Fantasies 
04:40 PM Rosanna Piccirillo, et al., IRCCS - "Mario Negri", Milan, Italy: MyoRep: a novel reporter system to detect 

early muscle atrophy in vivo 
05.00 PM Paolo Grumati, Telethon Institute of Genetics and Medicine, Naples, Italy: Selective autophagy and ER 

dynamics during muscle differentiation 
05:15 PM Bert Blaauw, University of Padua, Italy: The role of Akt-mTORC1 signaling in regulating muscle mass and 

function 
05:30 PM Tania Zaglia, et al., University of Padua, Italy: Circulating muscle-derived miR-206 links skeletal muscle 

dysfunction to heart sympathetic denervation 
 
05:45 PM Stefano Schiaffino, University of Padua, Italy: Who is Terje Lømo, a 88-year-YOUNG scientist still fully 

active! 
06:00 PM Lecture of Terje Lømo, University of Oslo, Norway: Body temperature regulation by muscle 

tone 
 
 
06:40 PM Complimentary Bus Transfer to Hotel Petrarca, Thermae of Euganean Hills (Padua), Italy  
 
 

08:00 PM Dinner in Hotel Petrarca 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  

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THURSDAY March 30, 2023  
Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy 

09:00 AM SESSION IV: FES managements of acquired muscle diseases,  
 Ines Bersch-Porada, Helmut Kern, Chairs 
 

09:00 AM Winfried Mayr, University of Vienna, Austria: Electrical stimulation in lower motoneuron lesions, from 
scientific evidence to clinical practice: a successful transition – The Engineer perspectives 

09:20 AM  Ines Bersch-Porada, Functional Electrical Stimulation Center, Notwill, Switzerland: Electrical stimulation 
in lower motoneuron lesions, from scientific evidence to clinical practice: a successful transition - The 
Physiotherapist experience and researcher perspective 

09:40 AM Ashraf Gorgey, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA: Home-
Based Electrical stimulation training for SCI perons with lower motor neuron injury 

10:00 AM Giovanna Albertin, University of Padua, Italy: Skin improvements by home-based FES 
10:15 AM Giovanni Pegoraro, Neuromuscular Rehabilitation Center, Fondazione Borghi, Varese, Italy: 

Neuromuscular electrical stimulation of hand in post-COVID syndrome 
10:30 AM Ugo Carraro, University of Padua, Italy: 40 years of basic and applied myology for hbDDM FES in 10 

slides 
 

10:45 AM  Break 
 
 

THURSDAY March 30, 2023 

Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy 
 

11:00 AM  Lecture of H. Lee Sweeney, University of Florida, Gainesville, FL, USA: Improving upon 
AAV.micro-dystrophin gene therapy for DMD 

 

11:40 AM SESSION Va: Genetic muscle diseases - Elisabeth R. Barton, H. Lee Sweeney, Chairs 
 

11:40 AM Kay Ohlendieck, Maynooth University, Maynooth, Co. Kildare, Ireland: Proteomic profiling of reactive 
myofibrosis in the aged and dystrophic diaphragm 

12:00 AM Philippe Perrin, et al., Development, Adaptation and Handicap, University of Lorraine, France: Postural 
control impairments in Fabry disease 

12:30 AM Lunch 
 

THURSDAY March 30, 2023  
Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy  

02:00 AM SESSION Vb: Genetic muscle diseases - Capucine Trollet, H. Lee Sweeney, Chairs 
 

02:00 AM Elisabeth R. Barton, University of Florida, Gainesville FL, USA: Novel role of store operated Ca2+ entry in 
Limb-Girdle Muscular Dystrophy 2A  

02.20 AM Capucine Trollet, Sorbonne Université, INSERM, Myology Institute, Paris, France: Cell and molecular 
actors of fibrosis in muscle diseases 

02.40 AM Massimo Ganassi, King’s College London, London, UK: Investigating pathogenic mechanisms in FSHD 
myogenesis 

 
 
 
 
 
 
 
 
 
 
 
  

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THURSDAY March 30, 2023  
Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy  

 

03:00 PM - SESSION VI: Twenty Years of AIM 
  Daniela Tavian, Corrado Angelini, Chairs 
 

03:00 PM Gabriele Siciliano et al., University of Pisa, Italy: Phenotype variabilities of laminopathies 
03:15 PM Alberto Benetollo, et al., DSB, University of Padua, Italy: Pharmacological profile of the most promising 

CFTR corrector for sarcoglycanopathy treatment 
03:30 PM  Francesco Dalla Barba, et al., DSB, University of Padua, Italy: Zebrafish and sarcoglycanopathies: 

Characterization of models suitable for phenotype-based screening of drugs 
03:45 PM Gulia Ricci,  et al., University of Pisa, Italy: New avenues for treatment of facioscapulohumeral MD 
04:00 PM Giovanna Cenacchi, et al., Alma Mater Studiorum University of Bologna, Italy: Two plasma circulating-

miRs for the diagnosis of idiopathic inflammatory myopathies 
04:15 PM Roberta Costa, et al., Alma Mater Studiorum University of Bologna, Italy: Morpho-functional 

characterization of Transportin3 in myogenic differentiation of a cell model of LGMD D2 
04:30 PM  Giosuè Annibalini, et al., University of Urbino Carlo Bo, Urbino, Italy: N-glycosylation inhibition impairs 

C2C12 and L6 myoblast differentiation and IGF-1 signalling 
04:30 PM Ester Tommasini, Daniela Tavian, et al., Milan, Italy: Irisin and sarcopenia: salivary irisin is induced by 

strenuous exercise and correlates with circulating irisin 
04:45 PM  Massimiliano Filosto, NeMO-Brescia Clinical Center for Neuromuscular Diseases, University of Brescia, 

Italy:  Clinical and genetic characterization of Neutral lipid storage disease with myopathy (NLSDM) 
 

05:00 PM  Braek 
 

05:15 PM Fabiola Moretti et al., Catholic University of Rome, Roma, Italy: Estrogens recover muscle regeneration 
impaired by the pathogenic gene, DUX4, in orthotopic human xenograft 

05:30 PM Abbass Jaber, et al., Evry University, Inserm, Evry, France: Perturbations of cholesterol metabolism in 
the dystrophic muscle in DMD 

05:45 PM Michele Guescini, et al., University of Urbino Carlo Bo, Italy: Modulation of vesicles’ secretion by EPS in 
an in vitro muscle model 

06:00 PM Alessia Geremia, et al., University of Padua, Italy: Activation of muscle-specific Akt1 reverts cancer-
dependent muscle wasting and reduces tumor mass 

 
06:15 PM Lecture of Jonathan Jarvis, Liverpool John Moores University, UK: Transcriptomic and 

growth responses to programmed resistance training in mouse, rat and human 
 

 
07.30 PM Dinner 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

  

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FRIDAY March 31, 2023 

Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy 
09.00 AM SESSION VII: Senescence & Rejuvenation 
  Nathan K. LeBrasseur, Christiaan Leeuwenburgh, Chairs 
09:00 AM Nathan K. LeBrasseur, Mayo Clinic, Rochester, MN, USA: Cellular senescence as a driver of skeletal 

muscle aging 
09:30 AM David Hood, York University, Canada: Impact of age and sex on lysosomes and mitophagy during muscle 

use and disuse 

10:00 AM Christiaan Leeuwenburgh, University of Florida, Gainesville, FL, USA: Inflammation, mitochondrial 
dysfunction senescense in skeletal muscle with aging and in peripheral artery disease 

10:30 AM Agnese De Mario, et al., University of Padua, Italy: Pharmacological modulation of MCU in skeletal 
muscle 

10:40 AM Maira Rossi, et al., University of Pavia, Italy: Nitrate supplementation promotes an anabolic response 
and attenuates neuromuscular alterations in 24-months old male mice 

10:50 AM Nicola Fiotti, et al., University of Trieste, Italy: Insulin resistance modification during bed rest: 
relationship with circulating and muscular MMP and TIMPs 

FRIDAY March 31, 2023 

ROOM B, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy 
09:30 AM  Practical Course on functional analysis of the stomatognathic system 
 Claudia Dellavia, Riccardo Rosati, Chairs 
09:30-11.00: Riccardo Rosati, Milan, Italy: Instrumental evaluations of the stomatognathic apparatus: static tests 
11:15-12:30: Claudia Dellavia, Milan, Italy: Instrumental evaluations of the stomatognathic apparatus: dynamic 

tests, 
For dentists who want to review/expand the functional analysis protocols of the stomatognathic system developed 
at the Laboratory of Functional Anatomy of the Stomatognathic Apparatus (LAFAS) of the University of Milan, Italy 
 

 

FRIDAY March 31, 2023 

Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy 
11:00 AM SESSION VIII: Muscle Fascia, biology and pathology - Carla Stecco, Alessandro Martini, Chairs  
 
11:00 AM Carla Stecco, University of Padua, Italy: Fascia and aging 
11:15 AM Diego Cazzador, et al., Otolaryngology Unit, Department of Neurosciences University of Padua, Italy: 

Tensor Tympani: unveiling a hidden muscle  
11:30 AM Carmelo Pirri, et al., University of Padua, Italy: Ultrasound imaging and fasciae 
11:45 AM Caterina Fede, et al., University of Padua, Italy: How sex hormones can affect the fasciae: Implication 

for pain 
12:00 AM Giovanna Albertin, et al., University of Padua, Italy: Lymphatic vessels detection in subcutis and 

superficial fascia 
12:15 AM Lucia Petrelli, et al., University of Padua, Italy: Innervation and vascularization of the superficial fascia 
12:30 AM Lorenza Bonaldi, et al., University of Padua, Italy: Biomechanical properties of the fascial system 
12.45 AM Ilaria Fantoni, et al., Orthopedics and Orthopedic Oncology, Department of Surgery, Oncology and 

Gastroenterology (DiSCOG), University of Padua, Italy: Fascia Lata alterations in hip osteoarthritis: An 
observational cross-sectional study 

13:00 PM Lunch 

  

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FRIDAY March 31, 2023    Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) 
Italy 
 

02:00 PM Lecture of Paolo Gargiulo, University of Rejkyavik, Iceland: 3D Quantitative Muscle 
Color Computed Tomography 

02:40 PM   SESSION IX: Non-invasive Assessments in Myology - Paolo Gargiulo, Ugo Carraro, Chairs 
02:40 PM Riccardo Forni, et al., University of Rejkyavik, Iceland: Virtual cardiac histology: a densitometric 

characterisation of left ventricular tissue 
02:50 PM Debora Jacob, et al., University of Rejkyavik, Iceland: Assessing early-stage Parkinson’s Disease using a 

moving platform (BioVRSea) 
03:00 PM Valentina Betti, et al., University of Rejkyavik, Iceland: An in silico 3d approach to evaluate bone 

remodelling after total hip arthroplasty: a six years longitudinal study 
03:10 PM Federica Ciliberti, et al., University of Rejkyavik, Iceland: Novel strategies for cartilage assessment, 

interplay between bone and muscles 
03:20 PM Carlo Ricciardi, Alfonso Maria Ponsiglione, University of Federico II, Naples, Italy: Interplay between the 

age and the asymmetry of NTRA in elderly people 
03:30 PM Magnus Gislason, et al., University of Rejkyavik, Iceland: Time shift of peak activation levels in 

quadriceps and hamstrings after ACL reconstruction during single leg jump 
03:40 PM Ettore Rocchi, et al., University of Urbino Carlo Bo, Urbino, Italy: Exploring myofibrillar alignement in 

muscular tissue 
 

FRIDAY March 31, 2023 

Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy 
04:00 PM   SESSION X:  Muscle Rehabilitation in Dentistry, Riccardo Rosati, Elena P. Ivanova, 

Chairs 
04:00 PM Elena P. Ivanova, Rehabilitation and Balneology Center, Moscow, Russia: Innovative methods of full 

dental rehabilitation 
04:15 PM  Gaia Pellegrini, University of Milan, Italy: Standardised protocols for sEMG of the masticatory muscles 

in oral rehabilitation  
04:30 PM Francesca Ferrante, et al., University of Pavia, Italy: Electromyographic analysis of masticatory muscles 

before and after rapid palatal expansion 
04:45 PM Roberto Rongo, University of Naples Federico II, Italy: Masticatory muscles pain management 
05:00 PM Mauricio Gonzalez Balut, Centro Ortodoncico Especializado, Mexico City, Mexico: Definite Orthodontic 

treatment for patients with Temporomandibular Joint problems and Craniomandibular Dysfunctions 
05:15 PM Bazar Amarsaikhan, Mongolia: Chewing hard food and its importance for general health 
05:30 PM Avtandil Bakradze, Tbilisi State Medical University, Tbilisi, Georgia: Peculiarities of the chewing muscles 

electrophysiological activity in mouth breathing individuals 
05:45 PM Mariana Dimova-Gabrovska, Department of Prosthetic Dentistry, Medical University-Sofia, Bulgaria: 

Craniomandibular dysfunctions – modern diagnostic methods 
06:00 PM Giuseppe Messina, et al., University of Palermo, Italy: Intra-articular ultrasound-guided injection with 

Hyaluronic Acid and corticosteroid in retrodiscal tissue for Temporomandibular disorders 
06:15PM Marieta Karadjova, et. al., Department of Neurology, Medical University-Sofia, Bulgaria: Improvement 

of gait, balance and coordination after application of Taopatch® device 
06:30 PM Francesco Mantia, et al., University of Palermo, Italy: Effects of Platelet-Rich-Plasma injection in 

association with therapeutic exercise in the management of medial epicondylitis 
 

06:45 PM Lecture of Feliciano Protasi University of Chieti, Italy: Mechanisms underlying exercise-
dependant remodelling of the sarcotubular system: the role of temperature and pH 

 

07:30 PM Dinner 
09:00 PM AFTER DINNER ACTIVITIES 
 

 

 

 

 

  

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SATURDAY April 1, 2023 
Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy 

09:00 AM Session XI: LBI workshop on muscle rehabilitation - from mouse to elderly 
 Sandra Zampieri, Feliciano Protasi, Chairs 
09:00 AM Feliciano Protasi, University of Chieti, Italy: Mimicking disuse and rehabiliation in a mouse model 
09:30 AM Antonio Musarò, University Sapienza of Rome, Italy: Molecular biological basis and effects of immobility 

and training in young and aging 
10:00 AM Sandra Zampieri, University of Padua, Italy: C-Terminal Agrin Fragment as a biomarker of muscle 

wasting and weakness in aging and disuse 
10:30 AM Jan Cvecka, University of Bratislava, Slovakia: Exercise intervention in elderly: a novel system within the 

Centre of Active Aging in Bratislava 
11:00 AM Nejc Sarabon, University of Primorska, Slovenia: Relationship between 24-hour movement behaviour 

and physical performance in older adults: A cross-sectional insight  into the Centre of active ageing data 
11:30 AM Stefan Loefler, Helmut Kern, LBI Rehabilitation Research, Vienna, Austria: AMB-REMOB – results of an 

early outpatient rehabilitation program 
12:00 AM Vincent Grote, Michael Fischer, LBI Rehabilitation Research, Vienna, Austria: Outcomes of early 

rehabilitation in elderly patients 
12.30 AM Lunch 
 

SATURDAY April 1, 2023 
12:30 AM Complimentary Transfer to Medical Hotel Ermitage (restricted to 15 Attendees) 

Medical Hotel Ermitage, Thermae of Euganean Hills (Padua) Italy 
12:45 PM Practical Actitvities on European Medical Thermalism - Stefano Masiero, Chair 
12:45 PM Working Lunch in Medical Hotel Ermitage 
01:15 PM Marco Maggia, Director of the Medical Hotel Ermitage: Balneotherapy, Mud and Physiotherapies for 

Prevention & Rehabilitation in the Medical Hotel Ermitage, a pioneering 15-year successful example 
02:00 pM Complimentary Transfer to Hotel Petrarca Thermae of Euganean Hills (Padua) Italy 
 
 

SATURDAY April 1, 2023 
Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy 

02:40 PM Lecture of Helmut Kern, LBI Rehabilitation Research, Vienna, Austria: Underwather 
physiotherapy after knee replacement 

03:20 PM SESSION XIIa: European Medical Thermalism and the World Federation Hydrotherapy 
(FEMTEC) - Umberto Solimene, Stefano Masiero, Chairs  

03:20 PM Umberto Solimene, Center Integrative Medicine, State University Milan, Italy: World Thermal Clusters  

03:40 PM Maria Chiara Maccarone, Ugo Carraro, Stefano Masiero, University of Padua, Italy: Balneology and 
Health Resort Medicine and rehabilitation in the Euganean Hills Thermae: building the future 

04:00 PM Daniele Coraci, et al. University of Padua, Italy: Technological transition of different rehabilitation 
approaches: challenges and answers 

 

04:20 PM Break 
 
 
 
 
 
 
 
 
 
 
 
 

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SATURDAY April 1, 2023 

Conference Hall, Hotel Petrarca, Thermae of Euganean Hills (Padua) Italy 
04:30 PM SESSION XIIb: European Medical Thermalism and the World Federation Hydrotherapy (FEMTEC) 

Stefano Masiero, Elena P. Ivanova, Chairs 
04:30 PM Anna Mihaylova, Medical University of Plovdiv, Bulgaria: Balneotherapy - prospects for the 

development of health tourism in Bulgaria 
04:50 PM Andrey Rachin, Rehabilitation and Balneology Center, Moscow, Russia: Modern methods of neuro-

rehabilitation 
05:10 PM Marcus Coplin, Balneology Association of North America, Naturopathic Healthcare, Pagosa Springs, 

Colorado, USA: A case study of balneotherapy in Fibromyalgia 
05:30 PM Maxim Yu. Yakovlev, et al., Rehabilitation and Balneology Center, Moscow, Russia: Correction of 

increased meteosensitivity of obese patients when using Terrainkur, taking into account the bioclimatic 
characteristics during stay in health resorts 

05:50 PM Kirill V. Terente,v et al., Moscow regional research clinical institute named after M.F. Vladimirsky, 
Moscow, Russia: Video analysis of patients’ gait during Terrainkur in obese people 

06:10 PM Irina A. Grishechkina, Rehabilitation and Balneology Center, Moscow, Russia: Outcomes of 
rehabilitation programs in patients with post-COVID-19 syndrome 

06:30 PM Stefano Masiero, University of Padua, Italy: Final remarks 
 
 

07:00 PM Ugo Carraro: Adijo, Adiós, Arrivederci, Auf Wiedersehen, Au revoir, Goodbye to the 
2024 Padua Days on Muscle and Mobility Medicine – Padua, Italy, March 13-16, 2024 

 
07:30 PM Dinner 
 

 
09:00 PM AFTER DINNER ACTIVITIES 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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SPONSORS 
 

***** 
 

***** 
CIR_ MYO, DEPARTMENT OF BIOMEDICAL SCIENCES, 

DEPARTMENT OF NEUROSCIENCE,  
of the UNIVERSITY OF PADUA, ITALY 

***** 

A&C M-C Foundation for Translational Myology, Padua, Italy 
***** 

E CON IL PATROCINIO 

 
 

  

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LAST-MINUTE ABSTRACTS 
of the2023 Pdm3 

 

WEDNESDAY March 29, 2023 
Aula Guariento, Galilean Academy of Arts, Letters 

and Science, Padua, Italy 
SESSION III: Adaptations in Aging: from 
molecules to functioning 

Amber L. Pond, Rosanna Piccirillo, Chairs 
 
 
2023Pdm3 March 29 - Abstract 98 
 
Circulating muscle-derived miR-206 links skeletal 
muscle dysfunction to heart sympathetic denervation 
 
Marco Ronfini (1,2),* Di Mauro V. (3),* Prando V. 
(1,2),* Franco-Romero A.  (1,2), Antonio Mazzaro (4), 
Favaro G.  (2), Lo Verso F. (2), Dokshokova L. (1,2), 
Armani A. (1,2), Gianni Sorarù (5), Guescini M. (6), 
Catalucci D. (3), Marco Mongillo (1,2), Marco Sandri 
(1,2),§ Tania Zaglia (1,2)§ - *, §, equal contributions 
 
(1) Department of Biomedical Sciences, University of Padova, 
Italy; (2), Veneto Institute of Molecular Medicine (VIMM), 
Padova, Italy; (3) Humanitas Research Hospital, Rozzano, 
Milan, Italy; (4) Department of Cardiac, Thoracic, Vascular 
Sciences and Public Health, Padova, Italy; (5), Department of 
Neuroscience, Azienda Ospedaliera di Padova, Padua, Italy; (6) 
Department of Molecular Sciences, University of Urbino Carlo 
Bo, Urbino, Italy. 
E-mail: tania.zaglia@unipd.it  
 
On-site presentation of unpublished results. The 
author denied Zoom circulation, recording and post-
meeting dissemination by YOUTUBE 
 
Pdm3 March 29 - April 1, 2023 

***** 

2023Pdm3 March 29 – Abstract 99 
 
Sympathetic neuropathology is revealed in muscles 
affected by Amyotrophic Lateral Sclerosis 
 
Antonio Mazzaro (1,2), Veronica Vita (1,2), Marco 
Ronfini (2,3), Irene Casola (4), Arianna Klein (2),   
Gabriella Dobrowolny (4), Gianni Sorarù (5), Antonio 
Musarò (4,6), Marco Mongillo (2,3,7),* Tania Zaglia 
(2,3)* - *, §, equal contributions 
 
(1) Department of Cardiac, Thoracic, Vascular Sciences 
and Public Health, University of Padua, Padua, Italy; (2) 
Veneto Institute of Molecular Medicine, Padua, Italy; (3) 
Department of Biomedical Sciences, University of 

Padua, Padua, Italy; (4), Laboratory Affiliated to Institute 
Pasteur Italia-Fondazione Cenci Bolognetti, DAHFMO-
Unit of Histology and Medical Embryology, Sapienza 
University of Rome, Rome, Italy; (5) Department of 
Neuroscience, Azienda Ospedaliera di Padova, Padua, 
Italy; (6) Scuola Superiore di Studi Avanzati Sapienza 
(SSAS), Sapienza University of Rome, Italy; (7) CNR 
Institute of Neuroscience, Padua, Italy. 
E-mail: tania.zaglia@unipd.it  
 
On-site presentation of unpublished results. The 
author denied Zoom circulation, recording and post-
meeting dissemination by YOUTUBE 
 
Pdm3 March 29 - April 1, 2023 

***** 

THURSDAY March 30, 2023  
Conference Hall, Hotel Petrarca,  

Thermae of Euganean Hills (Padua) Italy 
09:00 AM SESSION IV: 
FES managements of acquired muscle 
diseases 

Ines Bersch-Porada, Helmut Kern, Chairs 
 

 
2023Pdm3 March 29 – Abstract 100 
 
Neuromuscular electrical stimulation of hand in post-
COVID syndrome 
 
Giovanni Pegoraro (1), Alessandro Ambrosi (2) 
 
Neuromuscular Rehabilitation Center, Fondazione 
Borghi, Varese, Italy 
E-mail: pegogio@hotmail.com  
 
The global pandemic of coronavirus disease 2019 
(COVID-19) has revealed a surprising number of extra-
pulmonary manifestations of the SARS-CoV-2 infection. 
There have been emerging reports related to COVID-19 
infection and disease course including myositis, 
neuropathy, arthropathy, and soft tissue abnormalities in 
lower and upper limb too. NMES can be used to induce 
a muscle contraction when it is difficult or impossible for 
the person to achieve this voluntarily thereby allowing 
effective exercise and the strengthening of muscles 
observed that usual programs for amyotrophy couldn’t 
provide any muscular contraction. So we propose 
specific neuro muscular electrostimulation (NMES) 
parameters at low frequency to increase upper limb 

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muscles strength. We studied 10 patients who developed 
diffuse and symmetrical muscle weakness after a long 
stay in the intensive care unit (ICU). We applied 30 
minutes a day for two months three different frequency 
electrostimulation to: 
1. Arm extensor muscles because they provide help to 

the control of the trunk in sitting and standing position  
2.  Intrinsic muscles because of their severe ipotrophy. 
We applied the following parameters of frequency: 
1. Amyotrophy frequency 30-40 hz, 250 µs 
2. Study frequency 1-2 hz, 250 µs 
3. Triangular stimulation 0,2 hz, 250 µs 
Muscle contractions have been detected by visualization 
and a biofeedback EMG device. In the arm extensor at 
the beginning only low Frequency and high intensive 
stimulation could provide muscle contraction. After two 
months of high intensive stimulation, and physiotherapy, 
muscle normal excitability seemed to be restored. About 
hand intrinsic muscle, triangle impulse resulted the best 
parameters. We treated very severe weak muscle in 
patient after long covid. In conclusion, to reanimate 
muscular function of arm extensor muscles, hypotrophy 
muscle stimulation tetanic parameters have not provide 
any muscular activity. Only low frequency (1-2 hz) high 
intensity stimulation (80-120 mAmp) could achieve 
muscular contraction. 
Key Words: Skeletal muscle weakness; COVID-19 
pandemic syndrome; electrical stimulation parameters. 
References 
1. Segers J, Hermans G, Bruyninckx F, Meyfroidt G, 

Langer D, Gosselink R. Feasibility of neuromuscular 
electrical stimulation in critically ill patients. J Crit 
Care. 2014 Dec;29(6):1082-8. doi: 
10.1016/j.jcrc.2014.06.024. Epub 2014 Jun 30. 
PMID: 25108833. 

2. Routsi C, Gerovasili V, Vasileiadis I, Karatzanos E, 
Pitsolis T, Tripodaki E, Markaki V, Zervakis D, 
Nanas S. Electrical muscle stimulation prevents 
critical illness polyneuromyopathy: a randomized 
parallel intervention trial. Crit Care. 2010;14(2):R74. 
doi: 10.1186/cc8987. Epub 2010 Apr 28. PMID: 
20426834; PMCID: PMC2887197. 

 
Pdm3 March 29 - April 1, 2023 

***** 

 

 

 

 

 

 

 

THURSDAY March 30, 2023  
Conference Hall, Hotel Petrarca,  

Thermae of Euganean Hills (Padua) Italy 
SESSION VI: Twenty Years of AIM 

Daniela Tavian, Corrado Angelini, Chairs 
 

 
2023Pdm3 March 29 - Abstract 101 
 
Phenotype variabilities of laminopathies 
 
Gabriele Siciliano (1), Gabriele Vadi (1), Francesca Torri 
(1), Mariaconcetta Rende (1), Giovanna Lattanzi (2), 
Giulia Ricci (1) 
 
(1) Department of Clinical and Experimental Medicine, 
University of Pisa, Pisa, Italy; (2) CNR Institute of 
Molecular Genetics Unit of Bologna; IRCCS Istituto 
Ortopedico Rizzoli, Bologna, Italy. 
E-mail: gabriele.siciliano@unipi.it   
 
LMNA-related disorders, or laminopathies, are rare 
diseases caused by mutations in the LMNA gene, which 
encodes for the nuclear envelope proteins, lamin A and 
C, via alternative splicing. The main functions of lamins 
are to provide structural support to the nucleus, 
maintenance of nuclear shape and spacing of nuclear pore 
complexes. Over the years, numerous reports have 
suggested that lamins also take part in other process: 
chromatin organization, DNA replication, epigenetics, 
transcription, cell cycle regulation, cell development and 
differentiation, nuclear migration, and apoptosis. Lamins 
together with integral membrane proteins of nuclear 
envelope and associated proteins participate in the 
regulation of chromatin organization and formation of 
chromatin microdomains associated with nuclear 
envelope. Laminopathies are associated with a wide 
range of disease phenotypes, including neuromuscular, 
cardiac, metabolic disorders and premature aging 
syndromes. Different phenotypes with skeletal muscle 
involvement have been linked to LMNA mutations: 
limb-girdle muscular dystrophy type 1B (LGMD1B, old 
nomenclature); autosomal dominant Emery-Dreifuss 
muscular dystrophy (EDMD2) and the rarer recessive 
form (EDMD3), a form of congenital muscular 
dystrophy, the LMNA-related congenital muscular 
dystrophy (L-CMD). Although lamins A/C are expressed 
in almost all cells and tissues, the high degree of tissue-
specificity (i.e., skeletal muscle, cardiac muscle, adipose 
tissue, peripheral nerve) and the resulting different 
phenotypes observed in laminopathies are not completely 
elucidated. Moreover, therapeutic approaches to 
laminopathies are as yet symptomatic and no cure is 
currently available for any of these diseases. These 
considerations provide evidence of the extent to which an 
Italian Network for Laminopathies (NIL), involving 

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centers spread throughout Italy and involved in clinics, 
research, industry and patients and their associations can 
help in addressing the study of those diseases and finding 
a therapeutic strategy.  The use of corticosteroids to 
improve muscle power in of patients withL-CMD has 
been proposed,  despite to date there is no clear 
indications to support the use of corticosteroids in these 
patients and reliable biomarkers to demonstrate (or 
monitor) the effectiveness of the treatment is not 
available. Corticosteroids have anti-inflammatory 
activity and are able to modify the secretion of some 
cytokines. A study in a cohort of patients affected by 
muscular laminopathies found that TGF beta 2 secretion 
is consistently elevated in subjects with EDMD2 or other 
muscular laminopathies, except in L-CMD. Interestingly, 
our studies indicate that patients affected by L-CMD 
have a strongly altered profile of inflammatory cytokine 
secretion. This profile is also very different from that 
observed in patients affected by EDMD2, a form with 
later onset and slow progression of muscle disease. In 
fact, in L-CMD patients we observed an increase of 
interleukin 17, interleukin 9 and interleukin 1 receptor, 
whereas in patients with EDMD2 we reported a constant 
increase in TGFbeta 2 which was normal in L-CMD 
children. It is therefore reasonable to suppose that a 
different profile of the secretome may be related to the 
greater severity of the clinical picture of L-CMD. 
Starting from the collaborative approach and the 
multidisciplinary effort of the Italian Network for 
Laminopathies, we are performing an open-label 
prospective cohort pilot study to evaluate the effect of the 
treatment with Deflazacort in a cohort of clinically and 
molecularly well-characterized L-CMD patients. 

Key Words: Lamin A/C; laminopathies; limb-girdle 
muscular dystrophy type 1B; Emery-Dreifuss muscular 
dystrophy (EDMD2), LMNA-related congenital 
muscular dystrophy (L-CMD). 
References 
1. Kang SM, Yoon MH, Park BJ. Laminopathies; 

Mutations on single gene and various human genetic 
diseases. BMB Rep. 2018 Jul;51(7):327-337. doi: 
10.5483/bmbrep.2018.51.7.113. PMID: 29764566; 
PMCID: PMC6089866. 

2. Montano V, Mancuso M, Simoncini C, Torri F, Chico 
L, Ali G, Rocchi A, Baldinotti F, Caligo MA, Lattanzi 
G, Mattioli E, Cenacchi G, Barison A, Siciliano G, 
Ricci G. A Single mtDNA Deletion in Association 
with a LMNA Gene New Frameshift Variant: A Case 
Report. J Neuromuscul Dis. 2022;9(3):457-462. doi: 
10.3233/JND-220802. PMID: 35466949. 

3. Cappelletti C, Tramacere I, Cavalcante P, Schena E, 
Politano L, Carboni N, Gambineri A, D'Amico A, 
Ruggiero L, Ricci G, Siciliano G, Boriani G, Mongini 
TE, Vercelli L, Biagini E, Ziacchi M, D'Apice MR, 
Lattanzi G, Mantegazza R, Maggi L, Bernasconi P. 
Cytokine Profile in Striated Muscle Laminopathies: 
New Promising Biomarkers for Disease Prediction. 
Cells. 2020 Jun 23;9(6):1532. doi: 
10.3390/cells9061532. PMID: 32585971; PMCID: 
PMC7348753. 

4. Maggi L, D'Amico A, Pini A, Sivo S, Pane M, Ricci 
G, Vercelli L, D'Ambrosio P, Travaglini L, Sala S, 
Brenna G, Kapetis D, Scarlato M, Pegoraro E, Ferrari 
M, Toscano A, Benedetti S, Bernasconi P, Colleoni 
L, Lattanzi G, Bertini E, Mercuri E, Siciliano G, 
Rodolico C, Mongini T, Politano L, Previtali SC, 
Carboni N, Mantegazza R, Morandi L. LMNA-
associated myopathies: the Italian experience in a 
large cohort of patients. Neurology. 2014 Oct 
28;83(18):1634-44. doi: 
10.1212/WNL.0000000000000934. Epub 2014 Oct 
1. PMID: 25274841. 

5. Bernasconi P, Carboni N, Ricci G, Siciliano G, 
Politano L, Maggi L, Mongini T, Vercelli L, Rodolico 
C, Biagini E, Boriani G, Ruggiero L, Santoro L, 
Schena E, Prencipe S, Evangelisti C, Pegoraro E, 
Morandi L, Columbaro M, Lanzuolo C, Sabatelli P, 
Cavalcante P, Cappelletti C, Bonne G, Muchir A, 
Lattanzi G. Elevated TGF β2 serum levels in Emery-
Dreifuss Muscular Dystrophy: Implications for 
myocyte and tenocyte differentiation and fibrogenic 
processes. Nucleus. 2018 Jan 1;9(1):292-304. doi: 
10.1080/19491034.2018.1467722. PMID: 29693488; 
PMCID: PMC5973167. 

 
Pdm3 March 29 - April 1, 2023 

***** 

 

 

     

 
Phenotypic spectrum of muscular laminopathies (A,B L-CMD; 
C,D EDMD; E,F LGMD2B) 

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2023Pdm3 March 29 - Abstract 102 
 
New avenues for treatment of Facioscapulohumeral 
Muscular Dystrophy 
 
Giulia Ricci, Francesca Torri, Beatrice Ciurli, Gabriele 
Siciliano 
 
Department of Clinical and Experimental Medicine, 
University of Pisa, Italy 
E-mail: giulia.ricci@unipi.it    
 
Facioscapulohumeral muscular dystrophy (FSHD) is one 
of the most common forms of muscular dystrophy 
overall. Symptoms can present during childhood  up until 
late adulthood, with an average age at onset of 30 years; 
a selective pattern of skeletal muscle weakness and a 
wide spectrum of disease expression are commonly 
observed, also within the families. The pathogenic 
molecular mechanism is believed to reside in an aberrant 

expression of the DUX4 gene due to abnormal levels of 
hypomethylation in the D4Z4 region on chromosome 
4q35. DUX4 is a double-homeobox transcription factor 
that is normally expressed during em-bryogenesis and 
activates a core set of genes involved in zygotic   
development; it is then silenced in most adult tissues 
except thymus and testis. While evidence is growing 

about phenotypical variability and possible dif-ferent 
disease courses, knowledge of pathophysiologic 
mechanisms underlying those differences is still far from 
comprehensive. As clinical trials are finally approaching 
also for FSHD, understanding of the interplaying factors 
determining disease course, phenotypic characterization 
of patients, and choosing appropriate outcome measures 
is crucial for correct selection of molecules, trials’ design 
and selection of endpoints. To date, there are no approved 
treatments for FSHD and standard of care only implies 
personalized physical therapy and management of motor 
disability. In the last years we observed the evolution of 
FSHD clinical trials from non-specific anabolic or anti-
inflammatory/oxidant strategies, to cutting-edge 
molecular therapies targeting DUX4. The accepted 
hypothesis involving aberrant DUX4 expression in 
skeletal muscle has guided the research pipeline for 
targeted therapies, in particular treatments reducing 
DUX4 gene expression. Among them, Losmapimod, a 
p38-mitogen activated protein kinase inhibitor that has 
been studied in multiple fields from oncology to 
cardiovascular medicine, has been proposed as a novel 
treatment for FSHD and a phase III clinical trial is 
currently recruiting patients. 
Key Words: Facioscapolohumeral Muscular Dystrophy 
(FSHD); D4Z4; DUX4; D4Z4 methylation; epigenetic 
modifiers. 
References 
1. Wang LH, Tawil R. Current Therapeutic Approaches 

in FSHD. J Neuromuscul Dis. 2021;8(3):441-451. 
doi: 10.3233/JND-200554. PMID: 33579868; 
PMCID: PMC8203219. 

2. Caputo V, Megalizzi D, Fabrizio C, Termine A, 
Colantoni L, Caltagirone C, Giardina E, Cascella R, 
Strafella C. Update on the Molecular Aspects and 
Methods Underlying the Complex Architecture of 
FSHD. Cells. 2022 Aug 29;11(17):2687. doi: 
10.3390/cells11172687. PMID: 36078093; PMCID: 
PMC9454908. 

3. Mocciaro E, Runfola V, Ghezzi P, Pannese M, 
Gabellini D. DUX4 Role in Normal Physiology and 
in FSHD Muscular Dystrophy. Cells. 2021 Nov 
26;10(12):3322. doi: 10.3390/cells10123322. PMID: 
34943834; PMCID: PMC8699294. 

4. Nikolic A, Jones TI, Govi M, Mele F, Maranda L, 
Sera F, Ricci G, Ruggiero L, Vercelli L, Portaro S, 
Villa L, Fiorillo C, Maggi L, Santoro L, Antonini G, 
Filosto M, Moggio M, Angelini C, Pegoraro E, 
Berardinelli A, Maioli MA, D'Angelo G, Di Muzio A, 
Siciliano G, Tomelleri G, D'Esposito M, Della 
Ragione F, Brancaccio A, Piras R, Rodolico C, 
Mongini T, Magdinier F, Salsi V, Jones PL, Tupler R. 
Interpretation of the Epigenetic Signature of 
Facioscapulohumeral Muscular Dystrophy in Light 
of Genotype-Phenotype Studies. Int J Mol Sci. 2020 
Apr 10;21(7):2635. doi: 10.3390/ijms21072635. 
PMID: 32290091; PMCID: PMC7178248. 

       

 
       

 

Possible targeted therapeutic approaches to FSHD 
(Wang and Tawil 2021) 

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Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
Eur J Transl Myol 33 (1) 2023 11279. doi: 10.4081/ejtm.2023.11279 

- 20 - 

 

5. Ricci G, Ruggiero L, Vercelli L, Sera F, Nikolic A, 
Govi M, Mele F, Daolio J, Angelini C, Antonini G, 
Berardinelli A, Bucci E, Cao M, D'Amico MC, 
D'Angelo G, Di Muzio A, Filosto M, Maggi L, 
Moggio M, Mongini T, Morandi L, Pegoraro E, 
Rodolico C, Santoro L, Siciliano G, Tomelleri G, 
Villa L, Tupler R. A novel clinical tool to classify 
facioscapulohumeral muscular dystrophy 
phenotypes. J Neurol. 2016 Jun;263(6):1204-14. doi: 
10.1007/s00415-016-8123-2. Epub 2016 Apr 28. 
PMID: 27126453; PMCID: PMC4893383. 

 
Pdm3 March 29 - April 1, 2023 

***** 
2023Pdm3 March 29 - Abstract 103 
Lecture of Jonathan Jarvis 

Transcriptomic and growth responses to 
programmed resistance training in mouse, rat and 
human  
Jonathan Jarvis (1), Mark Viggars (1,2), Hazel 
Sutherland (1), Lauren Harlow (3), Christopher Cardozo 
(3) 
 
(1) School of Sport and Exercise Science, Liverpool John 
Moores University, UK; (2) Research Department of 
Physiology and Aging, University of Florida, 
Gainesville, Florida, USA; (3) National Center for the 
Medical Consequences of Spinal Cord Injury and 
Medical and Surgical Service, James J Peters VA 
Medical Center, Bronx, NY, USA. 
E-mail: J.C.Jarvis@ljmu.ac.uk  

Mice are commonly used to investigate muscle biology 
and disease, but many labs have found it difficult to 
produce whole muscle hypertrophy without chronic 
overload or very long periods of training. We have 
established a model of muscle growth in the rat using 
programmed contractions in which the plantar flexors are 
used to resist the dorsiflexors of the ankle [1, 2]. We will 
present data from experiments in the rat that show a 
marked increase of muscle mass, showing how the acute 
transcriptomic response 1 hour after an exercise session 
changes as a muscle adapts to daily exercise over 30 days. 
We will also show that a similar degree of hypertrophy is 
achieved after 30 days with exercise every three days, 
and that the transcriptomic response in this case shows 
less change towards an ‘endurance’ expression profile. 
We will also present evidence from experiments using 
the same approach in mice, comparing the transcriptomic 
response of mouse muscle and rat muscle to the same 
protocol. In mice we see similar changes in gene 
expression but no increase in muscle mass. Future 
comparison of the transcriptomic and protein synthetic 
and degradative mechanisms in these models will be 
informative. 

Key Words: Skeletal muscle hypertrophy; skeletal 
muscle transcriptome; exercise response; muscle 
adaptation. 
References 
1. Viggars MR, Sutherland H, Lanmüller H, Schmoll M, 

Bijak M, Jarvis JC. Adaptation of the transcriptional 
response to resistance exercise over 4 weeks of daily 
training. FASEB J. 2023 Jan;37(1):e22686. doi: 
10.1096/fj.202201418R. PMID: 36468768. 

2. Schmoll M, Unger E, Sutherland H, Haller M, Bijak 
M, Lanmüller H, Jarvis JC. SpillOver stimulation: A 
novel hypertrophy model using co-contraction of the 
plantar-flexors to load the tibial anterior muscle in 
rats. PLoS One. 2018 Nov20;13(11):e0207886. doi: 
10.1371/journal.pone.0207886. PMID: 30458051; 
PMCID: PMC6245836. 

 
Pdm3 March 29 - April 1, 2023 

***** 
 
 

 
 
 
 
 
 
 

 
 
Figure showing the percentage difference in mass 
between the left (daily stimulation) and right 
(contralateral unstimulated control) tibialis anterior 
muscles in rats (circles) and mice (squares). In mice 
we do not observe the progressive hypertrophy that 
is found in the rat with identical stimulation (100Hz, 
2s ON 2s OFF, 5 sets of 10 repetitions once per day 
with sets separated by 2.5 minutes of rest). Rat data 
from reference 1. 
 

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Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
Eur J Transl Myol 33 (1) 2023 11279. doi: 10.4081/ejtm.2023.11279 

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FRIDAY March 31, 2023 
Conference Hall, Hotel Petrarca,  

Thermae of Euganean Hills (Padua) Italy 
09:00 AM SESSION VII:  
Senescence&Rejuvenation 

Nathan K. LeBrasseur, Christiaan Leeuwenburgh, 
Chairs 

 
 
2023Pdm3 March 31 - Abstract 104 
 
Pharmacological modulation of MCU in skeletal 
muscle 
 
Agnese De Mario (1), Ilaria Piazza (1), Rosario Rizzuto 
(1), Cristina Mammucari (1,2) 
 
(1) Department of Biomedical Sciences, University of 
Padua, Italy; (2) Myology center (CIR-Myo), University 
of Padua, Italy. 
Email: agnese.demario@unipd.it  
 
Skeletal muscle mitochondria readily accumulate Ca2+ in 
response to SR store-releasing stimuli thanks to the 
activity of the mitochondrial calcium uniporter (MCU), 
the highly selective channel responsible for 
mitochondrial Ca2+ (mitCa2+) uptake. In skeletal muscle, 
MCU-dependent mitCa2+ positively regulates myofiber 
size by impinging on PGC1α4 and IGF1-AKT/PKB 
pathways.1 While the genetic modulation of the MCU has 
been widely applied, small molecules able to increase 
mitCa2+ uptake are rare. Spermine and related 
polyamines lower the threshold of mitCa2+ uptake.2 The 
p38 mitogen-activated protein kinase inhibitor 
SB202190 modulates mitCa2+ with a mechanism 
independent of p38 activity.3 Several natural plant 
flavonoids increase MCU activity independently of their 
antioxidant activity.4 Agonists and antagonists of the 
estrogen receptor as 4,4′,4″-(4-propyl-[1 h]-pyrazole-
1,3,5-triyl)trisphenol (PPT), diethylstilbestrol, and 17-β-
estradiol modulate the activity of the uniporter. By using 
a well-established methodology based on Aequorin, a 
calcium-sensitive probe that emits light upon Ca2+ 
binding, we screened a library of 1,600 FDA-approved 
drugs for their ability to modulate mitCa2+ uptake in 
living cells. We identified Amorolfine as a positive MCU 
modulator.5 Amorolfine is a morpholine antifungal drug 
that inhibits enzymes of the fungal sterol synthesis 
pathway and it is indicated for the topic treatment of 
mycoses. Amorolfine increases mitCa2+ uptake in Hela, 
C2C12 cells and adult isolated myofibers without 
affecting cytCa2+ and mitochondrial membrane potential. 
In agreement with the role of MCU in triggering 
hypertrophy, Amorolfine increases the size of C2C12 
myotubes in an MCU-dependent manner Moreover 
Amorolfine significantly increases the cross-sectional 

area of TA and EDL muscle fibers when injected for one 
week in TA muscles. In light of the role of mitCa2+ uptake 
in sustaining aerobic metabolism the positive modulation 
of MCU by Amorolfine increases oxygen consumption 
rate in flexor digitorum brevis (FDB)-isolated 
myofibers.5 Thus, the positive modulation of MCU by 
Amorolfine could be useful to sustain muscle trophsim in 
different conditions characterized by muscle atrophy. 
 Key Words: Skeletal muscle hypertrophy; mitochondrial 
calcium; positive MCU modulators; Amorolfine. 
References 
1. Mammucari C, Gherardi G, Zamparo I, Raffaello A, 

Boncompagni S, Chemello F, Cagnin S, Braga A, 
Zanin S, Pallafacchina G, Zentilin L, Sandri M, De 
Stefani D, Protasi F, Lanfranchi G, Rizzuto R. The 
mitochondrial calcium uniporter controls skeletal 
muscle trophism in vivo. Cell Rep. 2015 Mar 
3;10(8):1269-79. doi: 10.1016/j.celrep.2015.01.056. 
Epub 2015 Feb 26. PMID: 25732818; PMCID: 
PMC4351162. 

2. Nicchitta CV, Williamson JR. Spermine. A regulator 
of mitochondrial calcium cycling. J Biol Chem. 1984 
Nov 10;259(21):12978-83. PMID: 6238031.. 

3. Montero M, Lobaton CD, Moreno A, Alvarez J. A 
novel regulatory mechanism of the mitochondrial 
Ca2+ uniporter revealed by the p38 mitogen-
activated protein kinase inhibitor SB202190. FASEB 
J. 2002 Dec;16(14):1955-7. doi: 10.1096/fj.02-
0553fje. Epub 2002 Oct 4. PMID: 12368236. 

4. Montero M, Lobatón CD, Hernández-Sanmiguel E, 
Santodomingo J, Vay L, Moreno A, Alvarez J. Direct 
activation of the mitochondrial calcium uniporter by 
natural plant flavonoids. Biochem J. 2004 Nov 
15;384(Pt 1):19-24. doi: 10.1042/BJ20040990. 
PMID: 15324303; PMCID: PMC1134084. 

 
 
Amorolfine promotes skeletal muscle hypertrophy. 

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Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
Eur J Transl Myol 33 (1) 2023 11279. doi: 10.4081/ejtm.2023.11279 

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5. De Mario A, Tosatto A, Hill JM, Kriston-Vizi J, 
Ketteler R, Vecellio Reane D, Cortopassi G, 
Szabadkai G, Rizzuto R, Mammucari C. 
Identification and functional validation of FDA-
approved positive and negative modulators of the 
mitochondrial calcium uniporter. Cell Rep. 2021 Jun 
22;35(12):109275. doi: 10.1016/j.celrep.2021. 
109275. PMID: 34161774; PMCID: PMC8242467. 

 
Pdm3 March 29 - April 1, 2023 

***** 

FRIDAY March 31, 2023 
Conference Hall, Hotel Petrarca,  

Thermae of Euganean Hills (Padua) Italy 
10:30 AM SESSION VIII:  
Muscle Fascia, biology and pathology 

Carla Stecco, Alessandro Martini, Chairs 
 

 
2023Pdm3 March 31 – Abstract 105 
 
Tensor Tympani: unveiling a hidden muscle 
 
Diego Cazzador (1),  Valerio Maria Di Pasquale Fiasca 
(1), Davide Brotto (1), Giovanna Albertin (3), Laura 
Astolfi (2), Elisabetta Zanoletti (1), Alessandro Martini 
(2) 
 
(1) Section of Otolaryngology, Otolaryngology Unit, 
Department of Neurosciences, University of Padua, Italy; 
(2) Bioacoustics Research Laboratory, Department of 
Neurosciences, University of Padua, Italy; (3) 
Department of Human Anatomy and Physiology, 
University of Padua Medical School, Italy. 
E-mail: diego.cazzador@unipd.it  
 
The Tensor Tympani muscle (TTM), a small muscle 
placed in the medial-anterior portion of the middle ear 
cavity, represents a subject of lively debate. Its function 
and activity have been investigated for decades, but still 
remain unclear. Aiming to collect the available 
knowledge regarding this structure, the authors 
performed a review of the literature. Particular attention 
was dedicated to its anatomy and physiology. It is known 
that the TTM reacts to different stimuli, both auditory and 
non-auditory. It was hypothesized its role in the middle 
ear reflex to protect the cochlea from high-intensity 
noises, in synergy with the stapedius muscle. Moreover, 
the activity of the TTM was demonstrated to determine a 
conductive hearing loss by stiffening the ossicular chain. 
Other triggers for TTM contraction were described, such 
as vocalization, swallowing and chewing. A relationship 
was proposed between the TTM and the tensor veli 
palatini, two muscles both developing form the first 
pharyngeal arch, and other masticatory muscles. Some 

other non-auditory triggers can activate the TTM, 
including anticipation of loud sounds, orbital air jet and 
tactile stimulation of the face. Several theories regarding 
the function of TTM are still being postulated. Its neural 
connection with the brain and other muscles are still 
object of study. Its relationship with the eustachian tube 
could provide explanation to different pathological 
processes. Indeed, the function and activity of TTM have 
been speculated for decades, and nowadays it is not 
possible to state a definitive answer to its physiological 
role. 
Key Words: Fascia; Tensor Tympani; Middle ear 
muscles. 
References  
1. Fournier P, Paquette S, Paleressompoulle D, Paolino 

F, Devèze A, Noreña A. Contraction of the stapedius 
and tensor tympani muscles explored by 
tympanometry and pressure measurement in the 
external auditory canal. Hear Res. 2022 
Jul;420:108509. doi: 10.1016/j.heares.2022.108509. 
Epub 2022 Apr 27. PMID: 35568596. 

2. Stach BA, Jerger JF, Jenkins HA. The human acoustic 
tensor tympani reflex. A case report. Scand Audiol. 
1984;13(2):93-9. doi: 10.3109/01050398409043046. 
PMID: 6463558 

3. Rodríguez-Vázquez JF, Sakiyama K, Abe H, Amano 
O, Murakami G. Fetal Tendinous Connection 
Between the Tensor Tympani and Tensor Veli 
Palatini Muscles: A Single Digastric Muscle Acting 
for Morphogenesis of the Cranial Base. Anat Rec 
(Hoboken). 2016 Apr;299(4):474-83. doi: 
10.1002/ar.23310. Epub 2016 Jan 27. PMID: 
26744237 

 
Pdm3 March 29 - April 1, 2023 

***** 

2023Pdm3 March 31 - Abstract 61 
 
Fascia Lata alterations in hip osteoarthritis: An 
observational cross-sectional study 
 
Ilaria Fantoni (1), Carlo Biz (1), Chenglei Fan (2), 
Carmelo Pirri (2), Caterina Fede (2), Lucia Petrelli (2), 
Pietro Ruggieri (1), Raffaele De Caro (2), Carla Stecco 
(2) 
 
(1) Orthopedics and Orthopedic Oncology, Dept. of 
Surgery, Oncology and Gastroenterology, University of 
Padua; (2) Dept. of Neurosciences, Institute of Human 
Anatomy, University of Padua, Italy. 
E-mail: ilaria.fantoni@gmail.com  
 
The present study compares the structure and 
composition of fascia lata in healthy subjects and in 
patients with hip osteoarthritis (OA), to evaluate any 
differences in the amount of Collagen type I, Collagen 

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Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
Eur J Transl Myol 33 (1) 2023 11279. doi: 10.4081/ejtm.2023.11279 

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type III, and Hyaluronan. Fascia lata samples from 
voluntary healthy subjects and patients with OA were 
harvested during surgery. Collagen type I (COL I), III 
(COL III) antibody, and biotinylated hyaluronan binding 
protein (HABP) immunohistochemistry stainings were 
used to evaluate fascial morphology and COL I, COL III, 
and Hyaluronan (HA) content in both groups. Ten 
samples from healthy subjects (group A) and 11 samples 
from OA patients (group B) were collected. COL I was 
significantly more abundant in the OA group (p = 
0.0015), with a median percentage positivity of 75.2 
(IQR 13.11)%, while representing only 67 (IQR: 8.71)% 
in control cases. COL III, with median values of 9.5 (IQR 
3.63)% (OA group) and 17.10 (IQR 11)% (control cases), 
respectively, showed significant reduction in OA patients 
(p = 0.002). HA showed a median value of 10.01 (IQR 
8.11)% in OA patients, denoting significant decrease (p 
< 0.0001) with respect to the control group median 39.31 
(IQR 5.62)%.  The observed differences suggest a 
relationship between fascial pathology and hip OA. The 
observed increase in COL I in OA patients, along with 
the reduction of COL III and HA, could lead to fascial 
stiffening, which could alter fascial mechanics and be 
linked to the development and symptoms of OA. 
Key Words: Fascia; hip osteoarthritis; hyaluronan; 
collagen; stiffness; myofascial pain. 
References  
1. Fede C, Angelini A, Stern R, Macchi V, Porzionato 

A, Ruggieri P, De Caro R, Stecco C. Quantification 
of hyaluronan in human fasciae: variations with 
function and anatomical site. J Anat. 2018 
Oct;233(4):552-556. doi: 10.1111/joa.12866. Epub 
2018 Jul 24. PMID: 30040133; PMCID: 
PMC6131966. 

2. Stecco C, Stern R, Porzionato A, Macchi V, Masiero 
S, Stecco A, De Caro R. Hyaluronan within fascia in 
the etiology of myofascial pain. Surg Radiol Anat. 
2011 Dec;33(10):891-6. doi: 10.1007/s00276-011-
0876-9. Epub 2011 Oct 2. PMID: 21964857. 

3. Pratt RL. Hyaluronan and the Fascial Frontier. Int J 
Mol Sci. 2021 Jun 25;22(13):6845. doi: 
10.3390/ijms22136845. PMID: 34202183; PMCID: 
PMC8269293. 

4. Rees HW. Management of Osteoarthritis of the Hip. 
J Am Acad Orthop Surg. 2020 Apr 1;28(7):e288-

e291. doi: 10.5435/JAAOS-D-19-00416. PMID: 
31800436. 

5. Grässel S, Muschter D. Recent advances in the 
treatment of osteoarthritis. F1000Res. 2020 May 
4;9:F1000 Faculty Rev-325. doi: 
10.12688/f1000research.22115.1. PMID: 32419923; 
PMCID: PMC7199286. 

 
Pdm3 March 29 - April 1, 2023 

***** 

FRIDAY March 31, 2023 
Conference Hall, Hotel Petrarca,  

Thermae of Euganean Hills (Padua) Italy 
04:00 PM  SESSION X:   
Muscle Rehabilitation in Dentistry  

Riccardo Rosati, Elena P. Ivanova, Chairs 
 

***** 
2023Pdm3 March 31 - Abstract 76 
 
Peculiarities of the chewing muscles 
electrophysiological activity in mouth breathing 
individuals 
 
Avtandil Bakradze 
 
Dental Clinic and Training-Research Center “UniDent”, 
Tbilisi State Medical University, Tbilisi, Georgia 
Email: avt.bakradze@gmail.com  
 
Various factors, that play significant role in development 
of facial, bony structures, formation of normal growth 
and functionally correct dentition, have become the 
subject of increasing interest recently. According to the 
latest studies, neuromuscular balance is considered to be 
the main prerequisite for preventing relapse after 
orthodontic treatment and also the way to optimize its 
outcome. One of the main factors for normal growth of 
the jaws is not only masticatory muscles proper, 
coordinated work, but also its contractility (and therefore 
excitability) - physiological characteristics. It should be 
noted, that as a result of decreased muscle activity, 

 
Boxplot comparing the percentage antibody 
positivity for Collagen I, Collagen III and HABP. 
 

 
 
sEMG analysis of patient with mouth breathing type 

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Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
Eur J Transl Myol 33 (1) 2023 11279. doi: 10.4081/ejtm.2023.11279 

- 24 - 

 

significant changes in the location, size and growth of the 
jaws can develop, which can be manifested by the 
vertical growth of the face. The study was conducted on 
the group of 65 male and female volunteers. Several 
breathing tests were carried out to determine the 
breathing type. Cephalometric analysis was performed 
for all individuals to conclude the position, growth type 
and size of the jaws. In order to reduce the dentoalveolar 
proprioceptive signal, all subjects had been indicated to 
clench on the cotton rolls and the data was obtained 
during maximal voluntary contraction. In mouth 
breathing individuals, mean electromyographic activity 
of both masseter and temporalis muscles registered 
during maximal contraction, turned out to be 
inhomogeneous and asymmetric, occlusal anomalies had 
been noted, most often - skeletal second class. 
Key Words: Electromyography; mouth breathing; 
skeletal growth; masticatory muscles; neuromuscular 
balance.  
References 
1. Ferrario VF, Alessandro miani, Chiarella Sforza, 

Antonio D’Addona. Electromyographic activityof 
human mastica- tory muscles in normal young 
people. Statistical evaluation of reference values for 
clinical application, J Oral Rehabil. 
1993,May;20(3):271-80. 

2.  Souki BQ, Pimenta GB, Souki MQ, et al. Prevalence 
of malocclusion among mouth breathing children: do 
expectations meet reality? Int J Pediatr 
Otorhinolaryngol. 2009;73:767–773. 

3. Valera FC, Travitzki LV, Mattar SE, et al. Muscular, 
functional and orthodontic changes in preschool 
children with enlarged adenoids and tonsils. J Pediatr 
Otorhinolaringol. 2003;67:761–770. 

4. Vig KW. Nasal obstruction and facial growth: the 
strength of evidence for clinical assumptions. Am J 
Orthod Dentofacial Orthop. 1998;113:603–611. 

 
Pdm3 March 29 - April 1, 2023 

***** 
2023Pdm3 March 31 - Abstract 106 
 
Craniomandibular dysfunctions – modern diagnostic 
methods 
 
Mariana Dimova-Gabrovska 
 
Department of Prosthetic Dentistry, Medical University 
of Sofia 
Email: marianadimova@abv.bg   
 
To examine the uses of thermodiagnostics as part of the 
diagnostic protocol for patients with craniomandibular 
disorders (CMD) is the aim of this study. The 
investigation is based on 68 patients, divided into two 
groups: main group constituting 34 patients with CMD 
(22 women and 12 men, at 40.1± 13.6 years of age) and 

control group comprising 34 patients (20 women and 14 
men, at 45.7 ± 13,5 years of age). Thermo-visual 
diagnostics was carried out twice at an interval of 20 
days. Over that period of time only the patients with 
CMD received preprosthetic muscular preparation of the 
masticatory system. The analysis of thermal images from 
both tests in the control group indicated a high degree of 
thermal symmetry with the facial median line. Thermal 
images from patients of the main group in the first test 
revealed a significant percentage (91,4%) of high thermal 
intensities above the pathological threshold. In the 
second test, however, the positive thermographic 
findings decreased significantly in number, area and 
intensity. The results obtained demonstrate the benefit of 
infrared thermography for the visualization of basic 
muscular structures of the masticatory system with 
regard to norm and pathology. This method provides a 
clear image, documentary and diagnostic aid in the 
diagnosis for patients with CMD. 
Key Words: Craniomandibular disorders; diagnostic 
protocol; thermodiagnostics; thermal images; 
masticatory system.  
References 
1. Gratt BM, Graff-Radford SB, Shetty V, Solberg WK, 

Sickles EA. A 6-year clinical assessment of electronic 
facial thermography. Dentomaxillofac Radiol. 1996 
Nov;25(5):247-55. doi: 10.1259/dmfr.25.5.9161178. 
PMID: 9161178. 

2. Rossbach A, Tschernitschek H, Wichmann M, 
Landeberg Y. Der Einsatz der Thermographie als 
erweiterte diagnostische Möglichkeit im 
funktionsgestörten Kauorgan. [The use of 
thermography as an extended diagnostic option in the 
dysfunctional masticatory organ. German dentist 
Journal.] Dtsch. Zahnärztl. Z. 1993. 48: 561. 

3. Tschernitschek H, Bremer B. Die Kopf- und 
Halsregion im lateralen Thermographiebild [The 
head and neck region in the lateral thermographic 
image. Quintessence]. Quintessenz. 1995; 46: 1365. 

4. Dimova-Gabrovska M. Algorithm for Computerized 
Analysis of Static. Dynamic and Functional 
Occlusion in Patients with Bruxism and Bruxomania. 
Comptes rendus de l’Académie bulgare des Sciences. 
2019;72(2): 259-266.  

5. Dimova-Gabrovska M. Thermographic Assessment 
of Structural Analysis in Patients with 
Temporomandibular Disorders. Comptes rendus de 
l’Académie bulgare des Sciences. 2018;71(5):712-
716. 

 
Pdm3 March 29 - April 1, 2023 

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Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
Eur J Transl Myol 33 (1) 2023 11279. doi: 10.4081/ejtm.2023.11279 

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SATURDAY April 1, 2023 
Conference Hall, Hotel Petrarca, Thermae of 

Euganean Hills (Padua) Italy 
09:00 AM Session XI:  
LBI workshop on muscle rehabilitation - from 
mouse to elderly 

Sandra Zampieri, Feliciano Protasi, Chairs 
 

 

***** 
2023Pdm3 April 1 - Abstract 83 
 
C-Terminal Agrin Fragment as a biomarker of 
muscle wasting and weakness in aging and disuse 
 
Barbara Ravara (1), Elena Monti (2,3), Fabio Sarto (4) 
Martina Maino (1), Feliciano Protasi (5), Barbara 
Girolami (5), Antonio Musarò (6), Stefan Löfler (7), 
Helmut Kern (7), Marco Narici (4,8), Sandra Zampieri 
(1,4,7,8) 
 
(1) Department of Surgery, Oncology, and 
Gastroenterology, University of Padova, Padova, Italy; 
(2) Blau Laboratory, Stanford School of Medicine, 
Stanford, CA, USA; (3) Baxter Laboratory for Stem Cell 
Biology, Department of Microbiology and Immunology, 
Institute for Stem Cell Biology and Regenerative 
Medicine, Stanford School of Medicine, Stanford, CA, 
USA; (4) Department of Biomedical Sciences, 
University of Padova, Padua, Italy. (5) CAST, Center for 
Advanced Studies and Technology; University G 
D'Annunzio of Chieti-Pescara, Chieti, Italy; (6) Sapienza 
University of Rome, Italy; (7) Ludwig Boltzmann 
Institute for Rehabilitation Research, Wien, Austria; (8) 
CIR-MYO Myology Center, University of Padova, 
Padova, Italy. 
E-mail: sanzamp@unipd.it  
 
In the last decades, the extended human longevity 
resulted in increasing numbers of senior individuals in 
the general population. Ageing is accompanied by a 
progressive decline in muscle mass and function. It is 
associated with increased risk of adverse outcomes 
including knee or hip injuries and degeneration, falls, or 
bone fractures, possibly determining the onset of a 
clinical syndrome termed sarcopenia. Sarcopenia is not 
only caused by ageing (primary sarcopenia) but may be 
linked to the presence of several co-morbidities 
(secondary sarcopenia), such as disuse/inactivity, 
advanced organ failure, or inadequate intake of 
energy/proteins. Denervation and NMJ impairment have 
been proposed as key determinants of age-related muscle 
wasting and weakness. Thus, screening, monitoring and 
prevention of those conditions inducing muscle 
dysfunction is essential to improve the quality of life, 

potentially reducing ageing and sarcopenia-related social 
and economic costs. To this aim, the reliability and 
accessibility of non-invasive blood derived biomarkers is 
being evaluated. C-terminal Agrin Fragment (CAF), a 
circulating C-22 kDa peptide resulting from the 
proteolytic cleavage of agrin, a protein responsible for 
the neuromuscular junction (NMJ) assembly and 
maintenance, has been widely investigated by us and 
numerous other groups as circulating NMJ-related 
biomarker of muscle dysfunction. Essentially, serum 
CAF concentration was observed to increase with age 
and in sarcopenic individuals when compared to age-
matched, medically stable peers. Serum CAF was 
reported also to raise following chronic inactivity or 
disuse and seemed to be lowered or maintained by 
exercise training. Finally, CAF was found to correlate 
with appendicular lean mass, handgrip and gait speed. 
Therefore, CAF seems to be a specific biomarker for 
screening and monitoring muscle wasting and weakness. 
It may be a useful tool for tailored approaches of muscle 
rehabilitation and for prevention or rescue of muscle 
dysfunction. When findings will be confirmed on larger 
cohort of subjects, future guidelines may be implemented 
for introducing CAF as a biomarker in clinical settings. 
Key Words: C-terminal Agrin Fragment; aging; 
sarcopenia; muscle wasting; muscle weakness. 
References 
1. Hettwer S, Dahinden P, Kucsera S, Farina C, Ahmed 

S, Fariello R, Drey M, Sieber CC, Vrijbloed JW. 
Elevated levels of a C-terminal agrin fragment 
identifies a new subset of sarcopenia patients. Exp 
Gerontol. 2013 Jan;48(1):69-75. doi: 
10.1016/j.exger.2012.03.002. Epub 2012 Mar 11. 
PMID: 22433628.  

2. Gonzalez-Freire M, de Cabo R, Studenski SA, 
Ferrucci L. The Neuromuscular Junction: Aging at 
the Crossroad between Nerves and Muscle. Front 
Aging Neurosci. 2014 Aug 11;6:208. doi: 
10.3389/fnagi.2014.00208. PMID: 25157231; 
PMCID: PMC4127816. 

3. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère 
O, Cederholm T, Cooper C, Landi F, Rolland Y, 
Sayer AA, Schneider SM, Sieber CC, Topinkova E, 
Vandewoude M, Visser M, Zamboni M; Writing 
Group for the European Working Group on 
Sarcopenia in Older People 2 (EWGSOP2), and the 
Extended Group for EWGSOP2. Sarcopenia: revised 
European consensus on definition and diagnosis. Age 
Ageing. 2019 Jan 1;48(1):16-31. doi: 
10.1093/ageing/afy169. Erratum in: Age Ageing. 
2019 Jul 1;48(4):601. PMID: 30312372; PMCID: 
PMC6322506. 

4. Stephan A, Mateos JM, Kozlov SV, Cinelli P, Kistler 
AD, Hettwer S, Rülicke T, Streit P, Kunz B, 
Sonderegger P. Neurotrypsin cleaves agrin locally at 
the synapse. FASEB J. 2008 Jun;22(6):1861-73. doi: 
10.1096/fj.07-100008. Epub 2008 Jan 29. PMID: 
18230682. 

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- 26 - 

 

5. Monti E, Sarto F, Sartori R, Zanchettin G, Lofler S, 
Kern H, Narici M, Zampieri S. C-terminal agrin 
fragment as a biomarker of muscle wasting and 
weakness: a narrative review. Journal of Cachexia, 
Sarcopenia and Muscle, 2023 in press. DOI: 
10.1002/jcsm.13189. 

 
Pdm3 March 29 - April 1, 2023 

***** 
 
 
 
 
 

2023Pdm3 April 1 
 
Ugo Carraro 
 
University of Padua, Italy. 
Email: ugo.carraro@unipd.it  
 
Adijo, Adiós, Arrivederci, Auf Wiedersehen, Au revoir, 
Goodbye to the 2024 Padua Days on Muscle and 
Mobility Medicine (2024 Pdm3), Padua, Italy 
March 13-16, 2024. 
 
Pdm3 March 29 - April 1, 2023 

***** 

 
Index: Lecturers, Speakers, Authors 

 
Albertin Giovanna, p. 22  
Ambrosi Alessandro, p. 16 
Armani A., p. 16 
Astolfi Laura, p. 22 
Bakradze Avtandil, p. 23  
Biz Carlo, p. 23 
Brotto Davide, p. 22 
Casola Irene, p. 16 
Catalucci D., p. 16 
Cazzador Diego, p. 22 
Christopher Cardozo, p. 20 
Ciurli Beatrice, p. 19  
De Caro Raffaele, p. 23 
De Mario Agnese, p. 21 
Di Mauro V., p. 16 
Dimova Mariana, p. 24 
DiPasqualeFiasca Valerio, p. 22  
Dobrowolny Gabriella, p. 16 
Dokshokova L., p. 16  
Fan Chenglei, p. 23 
Fantoni Ilaria, p. 23 
Favaro G., p. 16 

Fede Caterina, p. 23 
Franco-Romero A., p. 16 
Girolami Barbara, p. 25 
Guescini M., p. 16 
Harlow Lauren, p. 20 
Jarvis Jonathan, p. 20 
Kern Helmut, p. 25 
Klein Arianna, p. 16 
Lattanzi Giovanna, p. 17 
Lo Verso F., p. 16 
Löfler Stefan, p. 25 
Maino Martina, p. 25 
Mammucari Cristina, p. 21  
Martini Alessandro, p. 22 
Mazzaro Antonio, p. 16, 16 
Mongillo Marco, p. 16, 16 
Monti Elena, p. 25  
Musarò Antonio, p. 16, 25 
Narici Marco, p. 25 
Pegoraro Giovanni, p. 16 
Petrelli Lucia, p. 23 
Piazza Ilaria, p. 21 

Pirri Carmelo, p. 23 
Prando V., p. 16 
Protasi Feliciano, p. 25  
Ravara Barbara, p. 25 
Rende Mariaconcetta, p. 17  
Ricci Giulia, p. 17, 19 
Rizzuto Rosario, p. 21 
Ronfini Marco, p. 16, 16 
Ruggieri Pietro, p. 23 
Sandri Marco, p. 16 
Sarto Fabio, p. 25 
Siciliano Gabriele, p. 17, 19 
Sorarù Gianni, p. 16, 16 
Stecco Carla, p. 23 
Sutherland Hazel, p. 20 
Torri Francesca, p.17, 19 
Vadi Gabriele, p.17 
Viggars Mark, p. 20 
Vita Veronica, p. 16 
Zaglia Tania, p. 16, 16 
Zampieri Sandra, p. 25 
Zanoletti Elisabetta, p. 22 

  

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Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
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27 

 

The Editorial Board page is available at: https://www.pagepressjournals.org/index.php/bam/board 

Editorial Board 2023 
Section Editors  
Myology Reviews 
Giorgio Fanò Illic, Alcatraz Free University, Perugia, Italy. - E-mail: fanoillic@gmail.com  

Muscle Genetics and Epigenetics  
Davide Gabellini, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.         
E-mail: gabellini.davide@hsr.it   
Viviana Moresi, National Research Council (CNR) Institute of Nanotechnology, Rome, Italy.  
E-mail: viviana.moresi@uniroma1.it 
Piera Smeriglio, Centre of Research in Myology, Institute of Myology, Sorbonne Université, INSERM, Paris, France. 
E-mail: p.smeriglio@institut-myologie.org  

Muscle Genetic Disorders: Etiology, Pathology, Therapy 
Corrado Angelini, Department of Neuroscience, Italy. E-mail: corrado.angelini@unipd.it  
Gabriele Siciliano, Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Italy. 
Email: g.siciliano@med.unipi.it  
H. Lee Sweeney, University of Florida, Gainesville, FL, USA. E-mail: lsweeney@ufl.edu   
Daniela Tavian, Laboratory of Cellular Biochemistry and Molecular Biology, Department of Psychology,  Catholic 
University of the Sacred Heart, Milan, Italy. E-mail: daniela.tavian@unicatt.it 

Molecular Myology  
Antonio Musarò, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of 
Rome, Italy. E-mail: antonio.musaro@uniroma1.it 
Amber Pond, Department of Anatomy, SIU School of Medicine, SIU Carbondale, IL, USA. 
E-mail: apond@siumed.edu 
Marco Sandri, Department of Biomedical Sciences, University of Padua, Italy. 
E-mail: marco.sandri@unipd.it 

Cellular Myology  
Dario Coletti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, 
Italy. E-mail: dario.coletti@uniroma1.it  
Guglielmo Sorci, Department of Medicine and Surgery, University of Perugia, Italy.  
E-mail: guglielmo.sorci@unipg.it  
Sandra Zampieri, Department of Surgery, Oncology, and Gastroenterology, University of Padua, Italy.         
E-mail: sanzamp@unipd.it  

Structural Myology  
Simona Boncompagni, Faculty of Medicine, University “G. D'Annunzio”, Chieti, Italy.                                 
E-mail: simona.boncompagni@unich.it  
Marzena Podhorska-Okolow, Department of Histology and Embryology, Medical University, Wroclaw, Poland.  
E-mail: marzena.podhorska@gmail.com 
Shantanu Sinha, Department of Radiology, University of California San Diego, San Diego, CA, USA 
E-mail: shsinha@ucsd.edu  

Muscle Development, Regeneration and / or Repair: Satellite Cells in 
Health and Disease 
Marina Bouchè, Sapienza University of Rome, Italy. E-mail: marina.bouche@uniroma1.it  
Massimo Ganassi, King’s College London, London, UK. E-mail: massimo.ganassi@kcl.ac.uk  

Physiology of Muscle and Mobility 
Jonathan C. Jarvis, School of Sport & Exercise Sciences, Liverpool John Moores University, UK.               
 E-mail: J.C.Jarvis@ljmu.ac.uk  
Marco Narici, Department of Biomedical Sciences, University of Padua, Italy. E-mail: marco.narici@unipd.it  
Carlo Reggiani, Department of Biomedical Sciences, University of Padua, Italy.                                               
E-mail: carlo.reggiani@unipd.it  

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mailto:fanoillic@gmail.com
mailto:gabellini.davide@hsr.it
mailto:viviana.moresi@uniroma1.it
mailto:p.smeriglio@institut-myologie.org
mailto:corrado.angelini@unipd.it
mailto:g.siciliano@med.unipi.it
mailto:lsweeney@ufl.edu
mailto:daniela.tavian@unicatt.it
mailto:antonio.musaro@uniroma1.it
mailto:apond@siumed.edu
mailto:marco.sandri@unipd.it
mailto:dario.coletti@uniroma1.it
mailto:guglielmo.sorci@unipg.it
mailto:sanzamp@unipd.it
mailto:simona.boncompagni@unich.it
mailto:marzena.podhorska@gmail.com
mailto:shsinha@ucsd.edu
mailto:marina.bouche@uniroma1.it
mailto:massimo.ganassi@kcl.ac.uk
mailto:J.C.Jarvis@ljmu.ac.uk
mailto:marco.narici@unipd.it
mailto:carlo.reggiani@unipd.it


Last-minute abstracts of 2023 Pdm3 and 2023 EJTM editorial board 
Eur J Transl Myol 33 (1) 2023 11279. doi: 10.4081/ejtm.2023.11279 

28 

 

Physical Exercise, Muscle and Health 
Paulo Gentil, College of Physical Education and Dance, Federal University of Goias, Golania, Brazil.          
 E-mail: paulogentil@hotmail.com  
Nejc Sarabon, Faculty of Health Sciences, University of Primorska, Slovenia. 
E-mail: nejc.sarabon@fvz.upr.si  
Paula Tavares, Faculty of Sport Sciences and Physical Education; University of Coimbra, Portugal.        
E-mail: tavaresc.paula@gmail.com 

Muscle Metabolism and Nutrition 
Gabriela Salim de Castro, Cancer Metabolism Research Group, Department of Surgery, University of São Paulo, São 
Paulo, Brazil. E-mail: gabriela.castro@usp.br  
Antonio Paoli, Department of Biomedical Sciences, University of Padova, Italy.                                               
E-mail: antonio.paoli@unipd.it  

Translational Myology for Physical Medicine and Rehabilitation 
Helmut Kern, Physiko- und Rheumatherapie, St. Poelten, Austria. - E-mail: helmut@kern-reha.at 
Stefano Masiero, Department of Neuroscience, Physical Medicine and Rehabilitation School, University of Padua, Italy. 
E-mail: stef.masiero@unipd.it 
Jannis Papathanasiou, Department of Kinesitherapy, Medical University of Sofia, Bulgaria/Faculty of Dental Medicine, 
Medical University of Plovdiv, Bulgaria. E-mail: giannipap@yahoo.co.uk  

Biomedical Engineering for Translational Myology 
Paolo Gargiulo, Institute for Biomedal and Neural Engineering, Reykjavik University, Iceland, Department of Science, 
Landspitali University Hospital, Iceland. E-mail: paologar@landspitali.is 
Winfried Mayr, Medical University of Vienna, Center for Medical Physics and Biomedical Engineering, Vienna, 
Austria. E-mail: winfried.mayr@meduniwien.ac.at 
Joseph Mizrahi, Department of Biomedical Engineering, Technion Israel Institute of Technology, Haifa, Israel.  
E-mail: jm@bm.technion.ac.il 

Mobility in Aging: Biology, Physiology, Prevention 
Christiaan Leeuwenburgh, Department of Aging and Geriatric Research, University of Florida Gainesville, Gainesville, 
FL, USA. E-mail: cleeuwen@ufl.edu 
Anna Picca, Department of Medicine and Surgery, LUM University, Casamassima (BA), Italy and 
Fondazione Policlinico Universitario "A. Gemelli", IRCCS, Rome Italy. E-mail: picca@lum.it 
Carmelinda Ruggiero, Department of Medicine, University of Perugia, Italy. E-mail: carmelinda.ruggiero@unipg.it  

Mobility Medicine: Diagnostics and Managements 
Claudia Dellavia, Department of Biomedical, Surgical and Dental Sciences, Università degli Studi, Milan, Italy. E-mail: 
claudia.dellavia@unimi.it  
Giuseppe Messina, Department of Psychology, Educational Science and Human Movement, University of Palermo, 
Italy. Email: giuseppe.messina17@unipa.it  
Riccardo Rosati, c/o Department of Biomedical, Surgical and Dental Sciences, Milan, Italy.  
E-mail: riccardo@riccardorosati.eu  
Roberto Stramare, Department of Medicine, Section of Radiology, University of Padua, Italy.  
E-mail: roberto.stramare@unipd.it   

Mobility Medicine: Muscle Fascia and Tendons 
Carla Stecco, Department of Neuroscience, University of Padova, Italy. E-mail: carla.stecco@unipd.it 

Mobility Medicine: Cognitive Functions and Clinical Psychology 
Mohsen Khosravi, Department of Psychiatry and Clinical Psychology, Zahedan University of Medical Sciences, 
Zahedan, Iran. E-mail: m.khosravi@zaums.ac.ir 
Patrizia Mecocci, Department of Medicine, University of Perugia, Italy. E-mail: patrizia.mecocci@unipg.it 
Hristina Milanova, Second Clinic of Physical and Rehabilitation Medicine, Military Medical Academy Sofia, Bulgaria. 
E-mail: ina.milanova@abv  

Mobility Medicine: Protocols, Perspectives, Communications and History 
Giorgio Fanò Illic, Alcatraz Free University, Perugia, Italy. - E-mail: fanoillic@gmail.com 
Maria Chiara Maccarone, Department of Neuroscience, Physical Medicine and Rehabilitation School, University of 
Padua, Italy. E-mail: mariachiara.maccarone@phd.unipd.it  
 
 

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mailto:paulogentil@hotmail.com
mailto:nejc.sarabon@iam.upr.si
mailto:tavaresc.paula@gmail.com
mailto:gabriela.castro@usp.br
mailto:antonio.paoli@unipd.it
mailto:helmut@kern-reha.at
mailto:stef.masiero@unipd.it
mailto:giannipap@yahoo.co.uk
mailto:paologar@landspitali.is
mailto:winfried.mayr@meduniwien.ac.at
mailto:jm@bm.technion.ac.il
mailto:cleeuwen@ufl.edu
mailto:picca@lum.it
mailto:carmelinda.ruggiero@unipg.it
mailto:claudia.dellavia@unimi.it
mailto:giuseppe.messina17@unipa.it
mailto:riccardo@riccardorosati.eu
mailto:roberto.stramare@unipd.it
mailto:carla.stecco@unipd.it
mailto:m.khosravi@zaums.ac.ir
mailto:patrizia.mecocci@unipg.it
mailto:ina.milanova@abv
https://mailweb.unipd.it/sso/groupware/imp/dynamic.php?page=message&buid=202317&mailbox=SU5CT1g&token=aBSPd2xpy5BDbmGJe5z3XFK&uniq=1578334437976
mailto:mariachiara.maccarone@phd.unipd.it


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Translational Mobility Medicine - Advisors 
Mauro Alaibac, Department of Medicine, Section of Dermatology Clinic, University of Padova, Italy.  
E-mail: mauro.alaibac@unipd.it 
Giovanna Albertin, Department of Neuroscience, Institute of Human Anatomy, University of Padova, Italy.     
E-mail: giovanna.albertin@unipd.it 
Elisabeth R. Barton, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 
USA. E-mail: erbarton@ufl.edu  
Ines Bersch-Porada, Head of International FES Centre®, Swiss Paraplegic Centre Nottwil, Switzerland. 
Email: ines.bersch@paraplegie.ch  
Manfred Bijak, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.  
E-mail: Manfred.Bijak@meduniwien.ac.at  
Claudio Cabello-Verrugio, Laboratory of Muscle Pathology, Fragility and Aging, Department of Biological Sciences, 
Universidad Andres Bello, Santiago, Chile. Email: claudio.cabello@unab.cl  
Marcus Coplin: The Balneology Association of North America at The Springs Resort, Pagosa Springs, Colorado USA. 
Email: drmarcus@gmail.com  
Kyle Edmunds, Department of Biomedical and Neural Engineering, Reykjavík University, Reykjavík, Iceland. 
E-mail: kylejedmunds@gmail.com 
Magnús Kjartan Gíslason, Institute of Biomedical and Neural Engineering, Reykjavik University, Reykjavik, Iceland. 
E-mail: magnuskg@ru.is  
Thórdur Helgason, Department of Research and Development, Landspitali University Hospital, Reykjavik, Iceland.  
E-mail: thordur@landspitali.is  
Christian Hofer, Otto Bock Healthcare Products GmbH, Vienna, Austria. 
E-mail: christian.hofer@ottobock.com   
David Israeli, Progressive Muscular Dystrophy unit, Genethon research institute, Paris-Saclay University, INSERM 
UMR_S951, Evry, France. Email: israeli@genethon.fr     
Elena P Ivanova, National Research Medical Center, Moscow, Russia, E-mail: IvanovaEP@nmicrk.ru  
Halldór Jónsson Jr, Landspitali University Hospital – Department of Orthopedics, Reykjavik, Iceland.  
E-mail: halldor@landspitali.is  
Žiga Kozinc, University of Primorska, Faculty of Health Sciences, Izola, Slovenia; University of Primorska, Andrej 
Marušič Institute, Koper, Slovenia. Email: ziga.kozinc@fvz.upr.si  
Hermann Lanmüller, Medical University of Vienna, Center for Medical Physics and Biomedical Engineering, Vienna, 
Austria. E-mail: hermann.Lanmueller@meduniwien.ac.at  
Lars Larsson, Department of Physiology and Pharmacology, Karolinska Institut, Stockolm, Sweden.              
E-mail: lars.larsson@ki.se  
Zehua Li, Department of Burn and Plastic Surgery, West China Hospital of Sichuan University, Chengdu, China. 
 Email: peter.lizh@foxmail.com 
Stefan Loefler, Ludwig Boltzmann Institute for Rehabilitation Research, St. Poelten, Austria                           
E-mail: stefan.loefler@rehabilitation.lbg.ac.at  
Ekaterina V. Makarova, PhD, Senior Research scientist at National Research Institute of Public Health n.a. N.А. 
Semashko, Moscow, Russia. - E-mail: baudolinoo@gmail.com   
Andrea Marcante, UOC Recovery and Functional Rehabilitation, Lonigo Hospital, Azienda ULSS 8 Berica, Lonigo, 
Italy. E-mail: andrea.marcante@aulss8.veneto.it 
Lorenzo Marcucci, Department of Biomedical Sciences, University of Padua, Italy.                                        
E-mail: lorenzo.marcucci@unipd.it 
Ryoichi Matsuda, Department of Science Education, Tokyo University of Science, Tokyo, Japan.                  
E-mail: cmatsuda1952@gmail.com 
Aram Megighian, Department of Biomedical Sciences, University of Padua, Italy.                                             
E-mail: aram.megighian@unipd.it 
Sara Missaglia, Laboratory of Cellular Biochemistry and Molecular Biology, Department of Psychology,  Catholic 
University of the Sacred Heart, Milan, Italy. E-mail: sara.missaglia@unicatt.it   
Yosuke Nagata, Department of Life Science, Okayama University of Science, Tokyo, Japan.                                                  
E-mail: nagata.yosuke@dls.ous.ac.jp  
Kay Ohlendieck, Department of Biology, Maynooth University, National University of Ireland, Maynooth, Co. 
Kildare, Ireland. E-mail: Kay.Ohlendieck@mu.ie  
Ketan Patel, School of Biological Sciences, University of Reading, UK. E-mail: ketan.patel@reading.ac.uk    

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mailto:mauro.alaibac@unipd.it
mailto:giovanna.albertin@unipd.it
mailto:erbarton@ufl.edu
mailto:ines.bersch@paraplegie.ch
mailto:Manfred.Bijak@meduniwien.ac.at
mailto:claudio.cabello@unab.cl
mailto:drmarcus@gmail.com
mailto:kylejedmunds@gmail.com
mailto:magnuskg@ru.is
mailto:thordur@landspitali.is
mailto:christian.hofer@ottobock.com
mailto:israeli@genethon.fr
mailto:IvanovaEP@nmicrk.ru
mailto:halldor@landspitali.is
mailto:ziga.kozinc@fvz.upr.si
mailto:hermann.Lanmueller@meduniwien.ac.at
mailto:lars.larsson@ki.se
mailto:peter.lizh@foxmail.com
mailto:stefan.loefler@rehabilitation.lbg.ac.at
mailto:baudolinoo@gmail.com
mailto:andrea.marcante@aulss8.veneto.it
mailto:lorenzo.marcucci@unipd.it
mailto:cmatsuda1952@gmail.com
mailto:aram.megighian@unipd.it
mailto:sara.missaglia@unicatt.it
mailto:nagata.yosuke@dls.ous.ac.jp
mailto:Kay.Ohlendieck@mu.ie
mailto:ketan.patel@reading.ac.uk


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Eur J Transl Myol 33 (1) 2023 11279. doi: 10.4081/ejtm.2023.11279 

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Andrey Rachin, National Medical Research Center of Rehabilitation and Balneology of Health Ministry of Russia.  
E-mail: RachinAP@nmicrk.ru  
Marco Recenti, Institute of Biomedical and Neural Engineering, Reykjavik University, Reykjavik, Iceland.  
E-mail: marco18@ru.is  
Carlo Ricciardi, Department of Electrical Engineering and Information Technology, University of Naples Federico II, 
Naples, Italy. E-mail: carloricciardi.93@gmail.com  
Marco B.L. Rocchi, Department of Biomolecular Sciences, Unit of Biostatistics, "Carlo Bo" University of Urbino, 
Italy. E-mail: marco.rocchi@uniurb.it 
Stanley Salmons, Department of Musculoskeletal Biology II, Institute of Ageing & Chronic Diseases; Faculty of 
Health & Life Sciences, University of Liverpool. UK. E-mail: s.salmons@liverpool.ac.uk  
Montserrat Samso, Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, 
USA. E-mail: msamso@vcu.edu  
Sheila Schils, EquiNew Therapy LLC, River Falls, WI, USA. Email: sbschils@EquiNew.com  
Usha Sinha, Department of Physics, San Diego State University, San Diego, CA, USA. 
E-mail: usinha@sdsu.edu   
Olga Surdu, Balneal and Rehabilitation Sanatorium of Techirghiol, Ovidius University of Constanta, Constanta 
County, Romania. E-mail: olga.surdu@yahoo.com  
Matthew Taylor, The University of Sydney Business School, Sydney, Australia. 
Email: mj.taylor.1290@gmail.com   
Lucrezia Tognolo, Department of Neuroscience, Physical and Rehabilitation Medicine, University of Padua, Italy.  
E-mail: lucrezia.tognolo@unipd.it  
Ester Tommasini, Laboratory of Cellular Biochemistry and Molecular Biology, Department of Psychology, Catholic 
University of the Sacred Heart, Milan, Italy. E-mail: ester.tommasini@unicatt.it  
Vincenzo Vindigni, Department of Neurosciences, Section of Plastic Surgery, University of Padova, Italy.  
Email: vincenzo.vindigni@unipd.it  
Mike Willand, Epineuron Technologies, Toronto, ON, Canada. E-mail: mwilland@epineurontech.com 
Zipora Yablonka-Reuveni, Department of Biological Structure, University of Washington School of Medicine, 
Seattle, WA, USA. E-mail: ziporareuveni206@gmail.com  
 
 

EJTM Editorial Board: Collection of E-mails 
Section Editors: fanoillic@gmail.com, gabellini.davide@hsr.it, viviana.moresi@uniroma1.it, p.smeriglio@institut-myologie.org, 
corrado.angelini@unipd.it, g.siciliano@med.unipi.it, daniela.tavian@unicatt.it, antonio.musaro@uniroma1.it, apond@siumed.edu, 
marco.sandri@unipd.it, dario.coletti@uniroma1.it, guglielmo.sorci@unipg.it, sanzamp@unipd.it, simona.boncompagni@unich.it, 
marzena.podhorska@gmail.com, shsinha@ucsd.edu, marina.bouche@uniroma1.it, massimo.ganassi@kcl.ac.uk, 
J.C.Jarvis@ljmu.ac.uk, marco.narici@unipd.it, carlo.reggiani@unipd.it, paulogentil@hotmail.com, gabriela.castro@usp.br, 
antonio.paoli@unipd.it, nejc.sarabon@iam.upr.si, nejc.sarabon@fvz.upr.si, tavaresc.paula@gmail.com, helmut@kern-reha.at, 
stef.masiero@unipd.it, paologar@landspitali.is, winfried.mayr@meduniwien.ac.at, jm@bm.technion.ac.il, cleeuwen@ufl.edu, 
patrizia.mecocci@unipg.it, picca@lum.it, claudia.dellavia@unimi.it, riccardo@riccardorosati.eu, giuseppe.messina17@unipa.it, 
roberto.stramare@unipd.it, carla.stecco@unipd.it,  m.khosravi@zaums.ac.ir, ina.milanova@abv 

Advisors: mauro.alaibac@unipd.it, giovanna.albertin@unipd.it, erbarton@ufl.edu, ines.bersch@paraplegie.ch, 
manfred.bijak@meduniwien.ac.at, claudio.cabello@unab.cl, drmarcuscoplin@gmail.com, kylejedmunds@gmail.com, 
magnuskg@ru.is, thordur@landspitali.is, christian.hofer@ottobock.com, israeli@genethon.fr, IvanovaEP@nmicrk.ru 
halldor@landspitali.is, ziga.kozinc@fvz.upr.si,  m.khosravi@zaums.ac.ir, hermann.Lanmueller@meduniwien.ac.at, 
lars.larsson@ki.se, peter.lizh@foxmail.com, stefan.loefler@rehabilitation.lbg.ac.at, mariachiara.maccarone@phd.unipd.it, 
baudolinoo@gmail.com, andrea.marcante@aulss8.veneto.it, lorenzo.marcucci@unipd.it, cmatsuda1952@gmail.com, 
aram.megighian@unipd.it, sara.missaglia@unicatt.it, nagata.yosuke@dls.ous.ac.jp, kay.ohlendieck@mu.ie, giannipap@yahoo.co.uk, 
ketan.patel@reading.ac.uk, RachinAP@nmicrk.ru, marco18@ru.is, carloricciardi.93@gmail.com, marco.rocchi@uniurb.it, 
carmelinda.ruggiero@unipg.it, s.salmons@liverpool.ac.uk, msamso@vcu.edu, sbschils@EquiNew.com, usinha@sdsu.edu, 
olga.surdu@yahoo.com, mj.taylor.1290@gmail.com, lucrezia.tognolo@unipd.it, ester.tommasini@unicatt.it, 
vincenzo.vindigni@unipd.it, mwilland@epineurontech.com, ziporareuveni206@gmail.com 
 

 

 
 

 

 

 

 

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mailto:RachinAP@nmicrk.ru
mailto:marco18@ru.is
mailto:carloricciardi.93@gmail.com
mailto:marco.rocchi@uniurb.it
mailto:s.salmons@liverpool.ac.uk
mailto:msamso@vcu.edu
mailto:sbschils@EquiNew.com
mailto:usinha@sdsu.edu
mailto:olga.surdu@yahoo.com
mailto:mj.taylor.1290@gmail.com
mailto:lucrezia.tognolo@unipd.it
mailto:ester.tommasini@unicatt.i
mailto:vincenzo.vindigni@unipd.it
mailto:mwilland@epineurontech.com
mailto:ziporareuveni206@gmail.com
mailto:fanoillic@gmail.com
mailto:gabellini.davide@hsr.it
mailto:viviana.moresi@uniroma1.it
mailto:p.smeriglio@institut-myologie.org
mailto:corrado.angelini@unipd.it
mailto:g.siciliano@med.unipi.it
mailto:daniela.tavian@unicatt.it
mailto:antonio.musaro@uniroma1.it
mailto:apond@siumed.edu
mailto:marco.sandri@unipd.it
mailto:dario.coletti@uniroma1.it
mailto:guglielmo.sorci@unipg.it
mailto:sanzamp@unipd.it
mailto:shsinha@ucsd.edu
mailto:marina.bouche@uniroma1.it
mailto:massimo.ganassi@kcl.ac.uk
mailto:J.C.Jarvis@ljmu.ac.uk
mailto:marco.narici@unipd.it
mailto:carlo.reggiani@unipd.it
mailto:paulogentil@hotmail.com
mailto:gabriela.castro@usp.br
mailto:antonio.paoli@unipd.it
mailto:nejc.sarabon@iam.upr.si
mailto:tavaresc.paula@gmail.com
mailto:helmut@kern-reha.at
mailto:stef.masiero@unipd.it
mailto:paologar@landspitali.is
mailto:patrizia.mecocci@unipg.it
mailto:claudia.dellavia@unimi.it
mailto:riccardo@riccardorosati.eu
mailto:giuseppe.messina17@unipa.it
mailto:carla.stecco@unipd.it
mailto:m.khosravi@zaums.ac.ir
mailto:ina.milanova@abv
mailto:mauro.alaibac@unipd.it
mailto:giovanna.albertin@unipd.it
mailto:erbarton@ufl.edu
mailto:ines.bersch@paraplegie.ch
mailto:drmarcuscoplin@gmail.com
mailto:israeli@genethon.fr
mailto:halldor@landspitali.is
mailto:ziga.kozinc@fvz.upr.si
mailto:peter.lizh@foxmail.com
mailto:giannipap@yahoo.co.uk
mailto:RachinAP@nmicrk.ru
mailto:ester.tommasini@unicatt.it
mailto:ziporareuveni206@gmail.com