id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eyereports-42	Stewart, Michael W.	What are the half-lives of ranibizumab and aflibercept (VEGF Trap-eye) in human eyes? Calculations with a mathematical model	2011	3	.pdf	application/pdf	2466	123	48	For rabbits, Bakri et al. determined ranibizum- ab and bevacizumab half-lives of 2.88 days and 4.32 days respectively;7,8 ii) Experimental pharma- cokinetic data from rabbits, monkeys and humans has been published for the 3 antibody based anti-VEGF drugs but only bevacizumab has been studied in all 3 species.3,4,6-13 Until human data for ranibizumab and the VTE become available, half-life calculations based upon a methodically derived mathematical model may provide the most accurate values.	cache/eyereports-42.pdf	txt/eyereports-42.txt