# eyereports: A Pathfinder

This is a computer-generated pathfinder created against the Distant Reader study called eyereports.

Each Distant Reader study carrel is composed of many individual items. Each item is bibliographically described with author, title, date, summary, and keyword values. Below is a list of the items' most signficant keywords as well as lists of the items themselves. Purpusing the content of this pathfinder provides the student, researcher, or scholar with one way to get their heads around the scope of the carrel. The keywords include:

> Eye; Patients; Interest; Visual; Cases; Tumor; Area; Bevacizumab; Lacrimal; Conjunctival

Depending on how this pathfinder was created, many of the bibliographic sections will include elaborations on the meaning(s) of the given keywords. These elaborations were generated by feeding the items' summaries to a large langauge model and asking the model to address the question, "What is X?", where "X" is the keyword. The result will be a few sentences of elaboration. Be forewarned. The elaborations are often plausible, but they should not be take as truth. Instead, they should be taken as points for consideration.

## Eye

- Late onset post-LASIK keratectasia with reversal and stabilization after use of latanoprost and corneal collagen cross-linking by Stojanovic, Aleksandar; Chen, Xiangjun; Zheng, Linyan; Xu, Yile; Stojanovic, Filip; Utheim, Tor Paaske (2012) - Progressive post- LASIK keratectasia; biomechanical insta- bility or chronic disease process? Although several risk factors for keratecta- sia after laser in situ keratomileusis (LASIK) have been identified and screening techniques continue to improve, post-LASIK keratectasia still occurs.1 A case of transient post-LASIK keratectasia associated with a marked eleva- tion of intraocular pressure (IOP), where the keratectasia subsided promptly after IOP nor- malization, has previously been reported.2 The current study reports a case of late onset post- LASIK-keratectasia associated with normal IOP, where reversal of keratectasia occurred after only minor IOP reduction after use of latanoprost. Keywords: eye; keratectasia; latanoprost; microns; right
- Orbital metastatic primary mediastinal neuroendocrine tumor: a histopathological case report by Alkatan, Hind; Ayoubi, Ayman (2012) - However, if we isolate these 7 orbital cases, the primary site was unknown in 3, was ileum in 3 and trachea in one case only.11 In a review by Shetlar et al. of 18 cases of orbital metastases, including 3 cases report- ed by the authors and an additional 15 cases reported by others, 11 were of gastrointestinal origin, the primary site was unknown in 5, mediastinal in one and trachea in one.4 Mehta et al. reported their 13 cases of orbital metastatic NET among whom 11 were of gastrointestinal origin (ileal in 7 and colonic in 4), and only one each from breast and bronchus. ©Copyright H. Alkatan and A. Ayoubi, 2012 Licensee PAGEPress, Italy Eye Reports 2012; 2:e3 doi:10.4081/eye.2012.e3 Non -co mmerc ial us e o nly [Eye Reports 2012; 2:e3] [page 11] the gastrointestinal and bronchial tract.1,3 Carcinoid syndrome may develop in a small number of patients, usually in association with metastatic disease, and it manifests as cuta- neous flushing, cyanosis, diarrhea, asthma and endocardial fibrosis.4 Ophthalmic mani- festations of this syndrome include conjuncti- val injection, intravascular sludging, perivas- cular pigment clumping and a decrease in the ophthalmic artery pressure that are believed to be attributed to serotonin and vasoactive pep- tides secreted by a functioning NET.5 Several cases of non-ocular NET in various anatomic locations have been reported; howev- er, primary orbital NET is rare.1,2 Orbital involvement by NET accounts for only 4-5% of all orbital metastatic disease and it is usually from a gastrointestinal primary tumor, while ocular uveal involvement is often from primary bronchopulmonary NETs.2,6 Bilateral orbital metastasis has been also reported.7,8 An overall high proportion of NET cases (15%) metastasize to the orbit, although it is considered a relatively rare site for metastatic disease.9 Of these cases of orbital involvement by NET, the majority of the metastases are from primary gastrointestinal tumors or tumors of unknown primary origin. Keywords: carcinoid; cases; eye; metastatic; net; neuroendocrine; orbit; tumor
- Orbital metastasis from cutaneous melanoma by Tsierkezou, Loukia; Cikatricis, Peter; Abdullah, Parveen; Elsherbiny, Samer (2012) - Introduction Metastatic cutaneous melanoma to the eye and the orbit is very rare.1-4 In autopsy series of metastatic cutaneous melanoma patients, the numbers of orbital metastases are reported ranging from 1-33%.5 Orbital metastases from cutaneous melanoma account for 5.3-15% from all metastatic tumors to the orbit.6 The most common primary source of metastatic tumors to the orbit is breast cancer (42%), followed by lung cancer (11%).3,5,7,8 Cutaneous malignant melanoma is reported to be the fourth most common.4 Patients often have advanced disease at the time of presentation and orbital metastases may be the initial sign. Keywords: eye; left; melanoma; metastases; metastatic; months; orbit; patient
- Diabetes and corneal endothelial cell characteristics: a study based on Eye Bank data by Brown, Geoffrey; Siegel, Eric; Staples, Steve; Doyle, Jennifer; Chang, Jason Y. (2011) - The aim of the article is to determine whether corneal endothelial cell density and other characteristics, such as cell area, pleo- morphism and polymegathism, are affected by diabetes. Corneal endothelial cell density and other characteristics of donor eyes collected during 2007 and 2008 in a local Eye Bank were measured by the HAI Eyebank Specular Microscope System. Keywords: age; cell; density; diabetes; diabetics; donors; endothelial; eye; eye status; non; status; subjects
- Bilateral pterygium in the two siblings by Ciftci, Suleyman; Ciftci, Leyla (2011) - We report a case of bilateral nasal pterygium in two sib- lings. I have previously report- ed a boy with bilateral nasal pterygium.20 This report is the first known report in the peer- reviewed medical literature of patients with bilateral nasal pterygium in siblings younger than the age of 15. Keywords: bilateral; eye; nasal; patients; pterygia; pterygium
- Enucleation assisted with filler for open-globe injury by Takahashi, Ayako; Akimoto, Masayuki; Hama, Sachiyo; Shirai, Yoko; Minamiguchi, Sachiko (2011) - Chin Med J (Engl) 2009;122:2961-6. 3. Savar A, Andreoli MT, Kloek CE, Andreoli CM. Enucleation for open globe injury. A new device for ocular globe enucleation. Keywords: alginate; enucleation; eye; globe; injury; resistance
- Idiopathic intracranial hypertension: a possible association with Imatinib by Palmowski-Wolfe, Anja M.; Pape, Eva; Baumann, Thomas; Todorova, Margarita G. (2011) - This process can be blocked with imatinib which results in a reduction of the number of pathologic tumor cells.1 Meanwhile imatinib is also applied to treat patients with gastrointesti- nal stromal tumors.1 Imatinib is the only FDA approved tyrosine kinase inhibitor for the treat- ment of patients with systemic mastocytosis, where a majority of patients excessively express the mast and stem cell growth factor receptor, SCFR or CD117, encoded by the KIT gene, and which has tyrosine kinase activity.2 As imatinib has only been on the market for a relatively short time, with time, new side effects are being described.1 We report a possible association between imatinib and Idiopathic intracranial hypertension (IIH). Mughal TI, Schrieber A. Principal long-term adverse effects of imatinib in patients with chronic myeloid leukemia in chronic phase. Keywords: eye; figure; hypertension; iih; imatinib; patient

## Patients

- Outcomes of 23-gauge pars plana vitrectomy in combined scleral buckling and vitrectomy for complex rhegmatogenous retinal detachments by Schoenberger, Scott D.; Miller, Daniel M.; Riemann, Christopher D.; Foster, Robert E.; Petersen, Michael R. (2011) - Ideally, a study to compare traditional 20-gauge PPV with scleral buckling and 23-gauge PPV with scleral buckling would help elucidate whether or not these complications are related to smaller gauge vitrectomy instruments and incisions, or related to the highly complex nature of retinal detachment repair in these patients. There has been a trend towards the use of smaller gauge vitrectomy instruments to treat increasing complex posterior segment patholo- gy.5-7 Twenty three- and 25-gauge instruments have been used in primary pseudophakic reti- nal detachment repair.8 There have also been reports of their use in more complex retinal detachments requiring silicone oil.9,10 There is a spectrum of pathology in the treatment of RRDs. Keywords: complications; detachment; eyes; gauge; hemorrhage; pars; patients; plana; ppv; surgery; visual; vitrectomy
- Spontaneous ipsilateral subconjunctival hemorrhage and the related risk factors by Kanonidou, Evgenia; Konidaris, Vasileios; Kanonidou, Christina; Ziakas, Nikolas (2011) - The purpose of this study was to assess the risk factors among patients with spontaneous ipsilateral SCH who presented to the outpatient department of our referral centre. Risk factors and complications of sub- conjunctival hemorrhages in patients tak- ing warfarin. Keywords: factors; hypertension; patients; risk; sch
- Detection of Helicobacter Pylori in the lacrimal sac mucosa of the patients with primary acquired nasolacrimal duct obstruction by Owji, Naser; Abtahi, Seyed Mohammad Bagher; Azarpira, Negar (2011) - H. pylori has been detected in dental plaque, saliva, tonsils, and adenoids.2,3 The oral cavity might be considered a reservoir for H. pylori.7 H. pylori has been found in nasal polyp, nasal mucosa and maxillary sinus mucosa in some patients with chronic sinusitis.4-6 The role of H. pylori infection in ophthalmic diseases such as chronic ocular inflammation, glaucoma,8 rosacea, and chronic blepharitis9 has been postulated. The role of H. pylori infection in the patho- genesis of upper respiratory system diseases has been evaluated by some investigators.14 It is speculated that there is a relationship between GERD and chronic rhinopharyngitis and rhinosinusitis in both children and adult.15-17 It is suggested that direct reflux of gastric juice into nasopharynx may cause mucosal edema and inflammation, leading to obstruction of sinus ostia.18 Recently focus has been on the possible direct role of H. pylori in tissue injury of the sinonasal mucosa and development of chronic rhinosinusitis.4,6 However, the causality has not been estab- lished yet. Keywords: duct; mucosa; nasal; nasolacrimal; obstruction; patients; pylori; sac

## Interest

- Tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) associated with Epstein-Barr virus by Jimenez, Beatriz; Ibanez-Alperte, Juan; Perez-Garcia, Diana; Minguez, Enrique; Cristobal, Jose A; Moros, Manuel (2015) - Department of Ophthalmology Accepted for Publication: April 1, 2014 “Lozano Blesa” University Clinic Hospital This work is licensed under a Creative Commons Attribution San Juan Bosco 15, ES-50009 Zaragoza, Spain Non-Commercial 3.0 License (CC BY-NC 3.0). Phone: +34 665802084 Licensee Ophthoscience Publishers, USA Keywords: interest
- Ocular melanocytosis and secondary glaucoma in a child by Kumar, Logandran Vijaya; Ming, Vivian Gong Hee (2015) - Raja Permaisuri Bainun Hospital Accepted for Publication: April 1, 2014 30990, Ipoh, Perak, Malaysia This work is licensed under a Creative Commons Attribution Email: drlogan2008@hotmail.com Non-Commercial 3.0 License (CC BY-NC 3.0). Phone: +60124205582 ©Copyright Kumar, et al., 2014. Keywords: interest
- Nd:YAG laser hyaloidotomy in a case of Valsalva retinopathy with premacular hemorrhage by Guler, Mete; Guler, Ozlem; Bilgin, Burak (2015) - Phone: +90 04162233800 Licensee Ophthoscience Publishers, USA Fax: +90 04162231690 ©Copyright Jimenez et al., 2014. Keywords: interest
- The changing rates and indications of optical coherence tomography and fundus fluorescein angiography over 5 years by Dooley, Ian; Ibrahim, Farah; O'Connor, Gerry (2015) - Email : ian.iandooley55@gmail.com ©Copyright Dooley et al., 2014. Phone: + Licensee Ophthoscience Publishers, USA Keywords: interest

## Visual

- Changes in ocular flow induced by hypo- and hypercapnia relate to static visual acuity in humans by Hayashi, Naoyuki; Ikemura, Tsukasa; Someya, Nami (2011) - We measured choroidal and retinal blood flow by laser speckle flowmetry as ocular blood flow, and static visual acuity using the Landolt C chart. These results suggest that changes in ocular blood flow induced by changes in arterial CO2 partial pressure influences visual acuity. Keywords: acuity; blood; blood flow; con; flow; hyper; hypo; rcv; subjects; treatment; velocity; visual
- Optic disc parameters in manifest and suspected glaucoma by Wanger, Peter; Vancea, Lucian; Martin, Lene (2011) - [Eye Reports 2011; 1:e12] Optic disc parameters in manifest and suspected glaucoma Peter Wanger,1 Lucian Vancea,2 Lene Martin1,3 1Department of Clinical Neuroscience, Ophthalmology & Vision, Karolinska Institutet, Stockholm; 2Eye Clinic, Sundsvalls hospital, Sundsvall; 3Academy of Health and Welfare, Mälardalen University, Eskilstuna, Sweden Abstract Structure and function measurements are important in glaucoma management. Recently, we developed a program which was designed to provide clinically relevant measures of optic disc parameters with a min- imum of user input.5 Keywords: area; disc; field; glaucoma; gps; optic; vfi; visual

## Cases

- Rhabdomyosarcoma mimicking lymphangioma: report of three cases by Guerriero, Silvana; Ciracì, Lorenza; Giancipoli, Ermete; Fiore, Maria Grazia; Piscitelli, Domenico (2012) - Rapid recurrence of the swelling led to further clinical evaluation, including a max- illofacial CT, which revealed an extensive nasal and orbital mass that was consistent with embryonal rhabdomyosarcoma on histopatho- logic analysis.7 Lazaridou et al. described a case of orbital rhabdomyosarcoma masquerad- ing as a lacrimal mucocele in a newborn infant.8 On the other hand, Cota et al. described an orbital abscess in a 6-year-old boy masquerading as a rhabdomyosarcoma9 In our case series, an expert sonographer and three different expert radiologists made an initially incorrect diagnosis in all cases. Suspected lacrimal mucocele in a newborn CT: homogenously hypodense mass Rhabdomyosarcoma patient with epiphora and swelling below the left medial canthus Our case #1 Suspected chalazion or lymphangioma in CT: solid mass in the medial-inferior part of the orbit, Rhabdomyosarcoma a patient with left inferior eyelid swelling homogeneous and hyperdense after contrast enhancement Our case #2 Suspected lymphangioma in a patient with CT: well-defined lesion with clear margins in the medial Rhabdomyosarcoma left eye exophthalmus segment of the left orbit, with several chambers, which were more evident after contrast enhancement MRI: irregular isointense tissue with an isointense peripheral rim and some central areas with a hyperintense signal Our case #3 Suspected lymphangioma in a patient with CT: lobular non-encapsulated mass, featuring the same Rhabdomyosarcoma superior left eyelid edema density as the extra-ocular muscles, well-defined against the surrounding soft tissues, with diffuse contrast enhancement Non -co mmerc ial us e o nly [page 6] Keywords: cases; diagnosis; eyelid; figure; lymphangioma; mass; orbital; rhabdomyosarcoma

## Tumor

- A rare case of WAGR syndrome with Peter anomaly by Adyanthaya, Rohit S.; Repka, Michael X. (2011) - These were a 2-month-old boy with the Peter anomaly and deletion of 11p13 who did not have Wilms tumor,1 a 6-day-old boy with the Peter anomaly and a Wilms tumor (chromosomal analysis was not performed)2 and a 1-month-old boy with deletion on chromosome 11p13-15.1 with an anomalous anterior segment and microphthal- mos with bilateral Wilms tumors developing at the age of 3 years.3 Our case of Peters anom- aly plus Wilms tumor presents further evi- dence of an association of WAGR syndrome and Peter anomaly. Discussion The occurrence of WAGR syndrome with Peter anomaly has been reported in three other patients to our knowledge. Keywords: anomaly; peter; syndrome; tumor; wagr; wilms

## Area

- The use of ocular coherence tomography in evaluating optic nerve health in eyes with large disc size by Weiss, Guy A.; Wollstein, Gadi; Naveh, Lilly; Landoy-Kalev, Maya; Ga'aton, Dany; Burgansky-Eliash, Zvia (2011) - Eighty-one eyes of 53 healthy patients were evaluated; 46 eyes had large discs (disc area ≥2.6 mm2) and 35 eyes had regular size discs (disc area <2.6 mm2). Correlation analysis revealed significant posi- tive association between disc area and cup parameters in the large disc group. Keywords: area; cup; disc; group; nerve; onh; optic; parameters; rim; rnfl

## Bevacizumab

- What are the half-lives of ranibizumab and aflibercept (VEGF Trap-eye) in human eyes? Calculations with a mathematical model by Stewart, Michael W. (2011) - For rabbits, Bakri et al. determined ranibizum- ab and bevacizumab half-lives of 2.88 days and 4.32 days respectively;7,8 ii) Experimental pharma- cokinetic data from rabbits, monkeys and humans has been published for the 3 antibody based anti-VEGF drugs but only bevacizumab has been studied in all 3 species.3,4,6-13 Until human data for ranibizumab and the VTE become available, half-life calculations based upon a methodically derived mathematical model may provide the most accurate values. Keywords: bevacizumab; days; intravitreal; life; lives; model; ranibizumab

## Lacrimal

- Oncocytoma of the upper conjunctival fornix by Al-Mohtaseb, Zaina; Lee, Seongmu; Yen, Michael T. (2011) - A 78-year-old female was referred for evalu- ation of fornix lesion. Ostergaard et al. examined the cytokeratin profile of oncocytic lesions of the ophthalmic region to investigate the origin of these tumors. Keywords: lacrimal

## Conjunctival

- Conjunctival blue nevus by Chen, Joseph Juyo; Lee, Seongmu; Yen, Michael T. (2011) - Conjunctival blue nevus. Malignant blue nevus: three new cases and a review of the literature. Keywords: conjunctival; lesions; malignant; nevi; nevus

## Epilogue

For more detail, about this study carrel, see the computed home page. For more detail about study carrels in general, see the read me file.

Created: 2025-12-22