id	sid	tid	token	lemma	pos
finefocus-2081	1	1	crispr	crispr	ADJ
finefocus-2081	1	2	•	•	NOUN
finefocus-2081	1	3	23	23	NUM
finefocus-2081	1	4	how	how	SCONJ
finefocus-2081	1	5	crisprmediated	crisprmediate	VERB
finefocus-2081	1	6	genome	genome	NOUN
finefocus-2081	1	7	editing	editing	NOUN
finefocus-2081	1	8	is	be	AUX
finefocus-2081	1	9	affecting	affect	VERB
finefocus-2081	1	10	undergraduate	undergraduate	NOUN
finefocus-2081	1	11	biology	biology	NOUN
finefocus-2081	1	12	education	education	NOUN
finefocus-2081	1	13	ethan	ethan	PROPN
finefocus-2081	1	14	s.	s.	PROPN
finefocus-2081	1	15	pickerill1	pickerill1	PROPN
finefocus-2081	1	16	*	*	PROPN
finefocus-2081	1	17	caleb	caleb	PROPN
finefocus-2081	1	18	m.	m.	PROPN
finefocus-2081	2	1	ebree2	ebree2	PROPN
finefocus-2081	2	2	*	*	PROPN
finefocus-2081	2	3	ben	ben	PROPN
finefocus-2081	2	4	a.	a.	PROPN
finefocus-2081	2	5	evans1	evans1	PROPN
finefocus-2081	2	6	elena	elena	PROPN
finefocus-2081	2	7	r.	r.	PROPN
finefocus-2081	2	8	north1	north1	PROPN
finefocus-2081	2	9	gennifer	gennifer	PROPN
finefocus-2081	2	10	m.	m.	NOUN
finefocus-2081	2	11	mager1	mager1	PROPN
finefocus-2081	3	1	douglas	douglas	PROPN
finefocus-2081	3	2	a.	a.	PROPN
finefocus-2081	3	3	bernstein1	bernstein1	PROPN
finefocus-2081	3	4	1	1	NUM
finefocus-2081	3	5	department	department	NOUN
finefocus-2081	3	6	of	of	ADP
finefocus-2081	3	7	biology	biology	NOUN
finefocus-2081	3	8	,	,	PUNCT
finefocus-2081	3	9	ball	ball	NOUN
finefocus-2081	3	10	state	state	PROPN
finefocus-2081	3	11	university	university	PROPN
finefocus-2081	3	12	,	,	PUNCT
finefocus-2081	3	13	muncie	muncie	PROPN
finefocus-2081	3	14	,	,	PUNCT
finefocus-2081	3	15	in	in	ADP
finefocus-2081	3	16	47306	47306	NUM
finefocus-2081	3	17	usa	usa	PROPN
finefocus-2081	3	18	2	2	NUM
finefocus-2081	3	19	department	department	NOUN
finefocus-2081	3	20	of	of	ADP
finefocus-2081	3	21	molecular	molecular	ADJ
finefocus-2081	3	22	genetics	genetic	NOUN
finefocus-2081	3	23	,	,	PUNCT
finefocus-2081	3	24	the	the	DET
finefocus-2081	3	25	ohio	ohio	PROPN
finefocus-2081	3	26	state	state	PROPN
finefocus-2081	3	27	university	university	PROPN
finefocus-2081	3	28	,	,	PUNCT
finefocus-2081	3	29	columbus	columbus	PROPN
finefocus-2081	3	30	,	,	PUNCT
finefocus-2081	4	1	oh	oh	INTJ
finefocus-2081	4	2	43210	43210	NUM
finefocus-2081	5	1	usa	usa	PROPN
finefocus-2081	5	2	copyright	copyright	NOUN
finefocus-2081	5	3	2019	2019	NUM
finefocus-2081	5	4	,	,	PUNCT
finefocus-2081	5	5	fine	fine	ADJ
finefocus-2081	5	6	focus	focus	VERB
finefocus-2081	5	7	all	all	DET
finefocus-2081	5	8	rights	right	NOUN
finefocus-2081	5	9	reserved	reserve	VERB
finefocus-2081	5	10	manuscript	manuscript	NOUN
finefocus-2081	5	11	recieved	recieve	VERB
finefocus-2081	5	12	24	24	NUM
finefocus-2081	5	13	september	september	PROPN
finefocus-2081	5	14	2019	2019	NUM
finefocus-2081	5	15	;	;	PUNCT
finefocus-2081	5	16	accepted	accept	VERB
finefocus-2081	5	17	12	12	NUM
finefocus-2081	5	18	decemeber	decemeber	PROPN
finefocus-2081	5	19	2018	2018	NUM
finefocus-2081	5	20	abstract	abstract	ADJ
finefocus-2081	5	21	corresponding	correspond	VERB
finefocus-2081	5	22	authors	author	NOUN
finefocus-2081	5	23	keywords	keyword	VERB
finefocus-2081	5	24	crispr	crispr	ADJ
finefocus-2081	5	25	protects	protect	VERB
finefocus-2081	5	26	bacteria	bacteria	NOUN
finefocus-2081	5	27	from	from	ADP
finefocus-2081	5	28	viruses	virus	NOUN
finefocus-2081	5	29	clustered	cluster	VERB
finefocus-2081	5	30	regularly	regularly	ADV
finefocus-2081	5	31	interspaced	interspace	VERB
finefocus-2081	5	32	short	short	ADJ
finefocus-2081	5	33	palindromic	palindromic	ADJ
finefocus-2081	5	34	repeats	repeat	NOUN
finefocus-2081	5	35	(	(	PUNCT
finefocus-2081	5	36	crispr	crispr	NOUN
finefocus-2081	5	37	)	)	PUNCT
finefocus-2081	5	38	are	be	AUX
finefocus-2081	5	39	short	short	ADJ
finefocus-2081	5	40	dna	dna	PROPN
finefocus-2081	5	41	repeats	repeat	NOUN
finefocus-2081	5	42	found	find	VERB
finefocus-2081	5	43	in	in	ADP
finefocus-2081	5	44	prokaryotic	prokaryotic	ADJ
finefocus-2081	5	45	genomes	genome	NOUN
finefocus-2081	5	46	(	(	PUNCT
finefocus-2081	5	47	1	1	NUM
finefocus-2081	5	48	)	)	PUNCT
finefocus-2081	5	49	.	.	PUNCT
finefocus-2081	6	1	these	these	DET
finefocus-2081	6	2	repeats	repeat	NOUN
finefocus-2081	6	3	are	be	AUX
finefocus-2081	6	4	interspersed	intersperse	VERB
finefocus-2081	6	5	with	with	ADP
finefocus-2081	6	6	non	non	ADJ
finefocus-2081	6	7	-	-	ADJ
finefocus-2081	6	8	repetitive	repetitive	ADJ
finefocus-2081	6	9	short	short	ADJ
finefocus-2081	6	10	sequences	sequence	NOUN
finefocus-2081	6	11	homologous	homologous	ADJ
finefocus-2081	6	12	to	to	PART
finefocus-2081	6	13	bacteriophage	bacteriophage	VERB
finefocus-2081	6	14	dna	dna	NOUN
finefocus-2081	6	15	(	(	PUNCT
finefocus-2081	6	16	figure	figure	NOUN
finefocus-2081	6	17	1	1	NUM
finefocus-2081	6	18	)	)	PUNCT
finefocus-2081	6	19	(	(	PUNCT
finefocus-2081	6	20	2	2	NUM
finefocus-2081	6	21	)	)	PUNCT
finefocus-2081	6	22	.	.	PUNCT
finefocus-2081	7	1	the	the	DET
finefocus-2081	7	2	discovery	discovery	NOUN
finefocus-2081	7	3	that	that	PRON
finefocus-2081	7	4	the	the	DET
finefocus-2081	7	5	interspersed	interspersed	ADJ
finefocus-2081	7	6	elements	element	NOUN
finefocus-2081	7	7	possess	possess	VERB
finefocus-2081	7	8	homology	homology	NOUN
finefocus-2081	7	9	to	to	PART
finefocus-2081	7	10	bacteriophage	bacteriophage	NOUN
finefocus-2081	7	11	genomes	genome	NOUN
finefocus-2081	7	12	lead	lead	NOUN
finefocus-2081	7	13	investigators	investigator	NOUN
finefocus-2081	7	14	to	to	PART
finefocus-2081	7	15	propose	propose	VERB
finefocus-2081	7	16	that	that	SCONJ
finefocus-2081	7	17	these	these	DET
finefocus-2081	7	18	short	short	ADJ
finefocus-2081	7	19	viral	viral	ADJ
finefocus-2081	7	20	elements	element	NOUN
finefocus-2081	7	21	provide	provide	VERB
finefocus-2081	7	22	bacteria	bacteria	NOUN
finefocus-2081	7	23	with	with	ADP
finefocus-2081	7	24	immunity	immunity	NOUN
finefocus-2081	7	25	against	against	ADP
finefocus-2081	7	26	invading	invade	VERB
finefocus-2081	7	27	viruses	virus	NOUN
finefocus-2081	7	28	.	.	PUNCT
finefocus-2081	8	1	indeed	indeed	ADV
finefocus-2081	8	2	,	,	PUNCT
finefocus-2081	8	3	crispr	crispr	ADJ
finefocus-2081	8	4	sequences	sequence	NOUN
finefocus-2081	8	5	were	be	AUX
finefocus-2081	8	6	found	find	VERB
finefocus-2081	8	7	to	to	PART
finefocus-2081	8	8	mediate	mediate	VERB
finefocus-2081	8	9	bacteriophage	bacteriophage	NOUN
finefocus-2081	8	10	resistance	resistance	NOUN
finefocus-2081	8	11	and	and	CCONJ
finefocus-2081	8	12	investigators	investigator	NOUN
finefocus-2081	8	13	identified	identify	VERB
finefocus-2081	8	14	crispr	crispr	NOUN
finefocus-2081	8	15	-	-	PUNCT
finefocus-2081	8	16	associated	associate	VERB
finefocus-2081	8	17	genes	gene	NOUN
finefocus-2081	8	18	(	(	PUNCT
finefocus-2081	8	19	cas	cas	NOUN
finefocus-2081	8	20	genes	gene	NOUN
finefocus-2081	8	21	)	)	PUNCT
finefocus-2081	8	22	that	that	PRON
finefocus-2081	8	23	were	be	AUX
finefocus-2081	8	24	also	also	ADV
finefocus-2081	8	25	important	important	ADJ
finefocus-2081	8	26	for	for	ADP
finefocus-2081	8	27	this	this	DET
finefocus-2081	8	28	viral	viral	ADJ
finefocus-2081	8	29	immunity	immunity	NOUN
finefocus-2081	8	30	(	(	PUNCT
finefocus-2081	8	31	3	3	NUM
finefocus-2081	8	32	,	,	PUNCT
finefocus-2081	8	33	4	4	NUM
finefocus-2081	8	34	)	)	PUNCT
finefocus-2081	8	35	.	.	PUNCT
finefocus-2081	9	1	bacteria	bacteria	NOUN
finefocus-2081	9	2	can	can	AUX
finefocus-2081	9	3	encode	encode	VERB
finefocus-2081	9	4	a	a	DET
finefocus-2081	9	5	wide	wide	ADJ
finefocus-2081	9	6	variety	variety	NOUN
finefocus-2081	9	7	of	of	ADP
finefocus-2081	9	8	cas	cas	NOUN
finefocus-2081	9	9	proteins	protein	NOUN
finefocus-2081	9	10	which	which	PRON
finefocus-2081	9	11	play	play	VERB
finefocus-2081	9	12	diverse	diverse	ADJ
finefocus-2081	9	13	functions	function	NOUN
finefocus-2081	9	14	in	in	ADP
finefocus-2081	9	15	bacteriophage	bacteriophage	NOUN
finefocus-2081	9	16	dna	dna	NOUN
finefocus-2081	9	17	cleavage	cleavage	NOUN
finefocus-2081	9	18	reviewed	review	VERB
finefocus-2081	9	19	in	in	ADP
finefocus-2081	9	20	(	(	PUNCT
finefocus-2081	9	21	5	5	NUM
finefocus-2081	9	22	)	)	PUNCT
finefocus-2081	9	23	.	.	PUNCT
finefocus-2081	10	1	briefly	briefly	NOUN
finefocus-2081	10	2	,	,	PUNCT
finefocus-2081	10	3	20	20	NUM
finefocus-2081	10	4	nucleotide	nucleotide	ADJ
finefocus-2081	10	5	crispr	crispr	NOUN
finefocus-2081	10	6	-	-	PUNCT
finefocus-2081	10	7	rna	rna	NOUN
finefocus-2081	10	8	(	(	PUNCT
finefocus-2081	10	9	crrna	crrna	NOUN
finefocus-2081	10	10	)	)	PUNCT
finefocus-2081	10	11	guides	guide	NOUN
finefocus-2081	10	12	transcribed	transcribe	VERB
finefocus-2081	10	13	from	from	ADP
finefocus-2081	10	14	the	the	DET
finefocus-2081	10	15	spacer	spacer	NOUN
finefocus-2081	10	16	regions	region	NOUN
finefocus-2081	10	17	inhibit	inhibit	VERB
finefocus-2081	10	18	bacteriophage	bacteriophage	NOUN
finefocus-2081	10	19	infection	infection	NOUN
finefocus-2081	10	20	by	by	ADP
finefocus-2081	10	21	targeting	target	VERB
finefocus-2081	10	22	a	a	DET
finefocus-2081	10	23	cas	cas	NOUN
finefocus-2081	10	24	nuclease	nuclease	NOUN
finefocus-2081	10	25	to	to	ADP
finefocus-2081	10	26	the	the	DET
finefocus-2081	10	27	viral	viral	ADJ
finefocus-2081	10	28	dna	dna	NOUN
finefocus-2081	10	29	using	use	VERB
finefocus-2081	10	30	complementary	complementary	ADJ
finefocus-2081	10	31	base	base	NOUN
finefocus-2081	10	32	pairing	pairing	NOUN
finefocus-2081	10	33	.	.	PUNCT
finefocus-2081	11	1	some	some	DET
finefocus-2081	11	2	crisprmediated	crisprmediate	VERB
finefocus-2081	11	3	viral	viral	ADJ
finefocus-2081	11	4	cleavage	cleavage	NOUN
finefocus-2081	11	5	systems	system	NOUN
finefocus-2081	11	6	also	also	ADV
finefocus-2081	11	7	require	require	VERB
finefocus-2081	11	8	a	a	DET
finefocus-2081	11	9	transactivating	transactivate	VERB
finefocus-2081	11	10	crispr	crispr	NOUN
finefocus-2081	11	11	-	-	PUNCT
finefocus-2081	11	12	rna	rna	NOUN
finefocus-2081	11	13	(	(	PUNCT
finefocus-2081	11	14	tracrrna	tracrrna	NOUN
finefocus-2081	11	15	)	)	PUNCT
finefocus-2081	11	16	for	for	ADP
finefocus-2081	11	17	maturation	maturation	NOUN
finefocus-2081	11	18	of	of	ADP
finefocus-2081	11	19	crrna	crrna	NOUN
finefocus-2081	11	20	(	(	PUNCT
finefocus-2081	11	21	6	6	NUM
finefocus-2081	11	22	)	)	PUNCT
finefocus-2081	11	23	.	.	PUNCT
finefocus-2081	12	1	in	in	ADP
finefocus-2081	12	2	addition	addition	NOUN
finefocus-2081	12	3	,	,	PUNCT
finefocus-2081	12	4	cleavage	cleavage	NOUN
finefocus-2081	12	5	of	of	ADP
finefocus-2081	12	6	viral	viral	ADJ
finefocus-2081	12	7	genome	genome	NOUN
finefocus-2081	12	8	also	also	ADV
finefocus-2081	12	9	requires	require	VERB
finefocus-2081	12	10	a	a	DET
finefocus-2081	12	11	short	short	ADJ
finefocus-2081	12	12	,	,	PUNCT
finefocus-2081	12	13	2	2	NUM
finefocus-2081	12	14	-	-	SYM
finefocus-2081	12	15	6	6	NUM
finefocus-2081	12	16	nucleotide	nucleotide	NOUN
finefocus-2081	12	17	,	,	PUNCT
finefocus-2081	12	18	protospacer	protospacer	NOUN
finefocus-2081	12	19	adjacent	adjacent	ADJ
finefocus-2081	12	20	motif	motif	NOUN
finefocus-2081	12	21	(	(	PUNCT
finefocus-2081	12	22	pam	pam	NOUN
finefocus-2081	12	23	)	)	PUNCT
finefocus-2081	12	24	in	in	ADP
finefocus-2081	12	25	the	the	DET
finefocus-2081	12	26	viral	viral	ADJ
finefocus-2081	12	27	sequence	sequence	NOUN
finefocus-2081	12	28	(	(	PUNCT
finefocus-2081	12	29	79	79	NUM
finefocus-2081	12	30	)	)	PUNCT
finefocus-2081	12	31	.	.	PUNCT
finefocus-2081	13	1	the	the	DET
finefocus-2081	13	2	dual	dual	ADJ
finefocus-2081	13	3	requirement	requirement	NOUN
finefocus-2081	13	4	of	of	ADP
finefocus-2081	13	5	the	the	DET
finefocus-2081	13	6	20	20	NUM
finefocus-2081	13	7	base	base	NOUN
finefocus-2081	13	8	guide	guide	NOUN
finefocus-2081	13	9	and	and	CCONJ
finefocus-2081	13	10	adjacent	adjacent	ADJ
finefocus-2081	13	11	pam	pam	NOUN
finefocus-2081	13	12	sequence	sequence	NOUN
finefocus-2081	13	13	provides	provide	VERB
finefocus-2081	13	14	a	a	DET
finefocus-2081	13	15	high	high	ADJ
finefocus-2081	13	16	degree	degree	NOUN
finefocus-2081	13	17	of	of	ADP
finefocus-2081	13	18	specificity	specificity	NOUN
finefocus-2081	13	19	limiting	limit	VERB
finefocus-2081	13	20	off	off	ADP
finefocus-2081	13	21	-	-	PUNCT
finefocus-2081	13	22	target	target	NOUN
finefocus-2081	13	23	or	or	CCONJ
finefocus-2081	13	24	bacterial	bacterial	ADJ
finefocus-2081	13	25	genome	genome	NOUN
finefocus-2081	13	26	cleavage	cleavage	NOUN
finefocus-2081	13	27	.	.	PUNCT
finefocus-2081	14	1	douglas	douglas	PROPN
finefocus-2081	14	2	a.	a.	PROPN
finefocus-2081	14	3	bernstein	bernstein	PROPN
finefocus-2081	14	4	dabernstein@bsu.edu	dabernstein@bsu.edu	VERB
finefocus-2081	14	5	tel	tel	PROPN
finefocus-2081	14	6	:	:	PUNCT
finefocus-2081	14	7	(	(	PUNCT
finefocus-2081	14	8	765)-285	765)-285	NUM
finefocus-2081	14	9	-	-	SYM
finefocus-2081	14	10	8851	8851	NUM
finefocus-2081	14	11	*	*	PUNCT
finefocus-2081	15	1	authors	author	NOUN
finefocus-2081	15	2	contributed	contribute	VERB
finefocus-2081	15	3	equally	equally	ADV
finefocus-2081	15	4	to	to	ADP
finefocus-2081	15	5	this	this	DET
finefocus-2081	15	6	work	work	NOUN
finefocus-2081	15	7	•	•	NOUN
finefocus-2081	15	8	clustered	cluster	VERB
finefocus-2081	15	9	regularly	regularly	ADV
finefocus-2081	15	10	interspaced	interspace	VERB
finefocus-2081	15	11	short	short	ADJ
finefocus-2081	15	12	palindromic	palindromic	ADJ
finefocus-2081	15	13	repeats	repeat	NOUN
finefocus-2081	15	14	•	•	ADV
finefocus-2081	15	15	crispr	crispr	ADJ
finefocus-2081	15	16	•	•	NOUN
finefocus-2081	15	17	genome	genome	NOUN
finefocus-2081	15	18	editing	edit	VERB
finefocus-2081	15	19	•	•	NOUN
finefocus-2081	15	20	biology	biology	NOUN
finefocus-2081	15	21	education	education	NOUN
finefocus-2081	15	22	•	•	NOUN
finefocus-2081	15	23	course	course	NOUN
finefocus-2081	15	24	-	-	PUNCT
finefocus-2081	15	25	based	base	VERB
finefocus-2081	15	26	undergraduate	undergraduate	NOUN
finefocus-2081	15	27	research	research	NOUN
finefocus-2081	15	28	experiences	experience	NOUN
finefocus-2081	16	1	•	•	PRON
finefocus-2081	16	2	cures	cure	NOUN
finefocus-2081	16	3	in	in	ADP
finefocus-2081	16	4	2010	2010	NUM
finefocus-2081	16	5	,	,	PUNCT
finefocus-2081	16	6	the	the	DET
finefocus-2081	16	7	crispr	crispr	ADJ
finefocus-2081	16	8	/	/	SYM
finefocus-2081	16	9	cas	cas	NOUN
finefocus-2081	16	10	system	system	NOUN
finefocus-2081	16	11	of	of	ADP
finefocus-2081	16	12	streptococcus	streptococcus	NOUN
finefocus-2081	16	13	thermophilus	thermophilus	NOUN
finefocus-2081	16	14	was	be	AUX
finefocus-2081	16	15	found	find	VERB
finefocus-2081	16	16	necessary	necessary	ADJ
finefocus-2081	16	17	and	and	CCONJ
finefocus-2081	16	18	sufficient	sufficient	ADJ
finefocus-2081	16	19	to	to	PART
finefocus-2081	16	20	cleave	cleave	VERB
finefocus-2081	16	21	bacteriophage	bacteriophage	NOUN
finefocus-2081	16	22	dna	dna	NOUN
finefocus-2081	16	23	.	.	PUNCT
finefocus-2081	17	1	since	since	SCONJ
finefocus-2081	17	2	this	this	DET
finefocus-2081	17	3	time	time	NOUN
finefocus-2081	17	4	,	,	PUNCT
finefocus-2081	17	5	crispr	crispr	PROPN
finefocus-2081	17	6	went	go	VERB
finefocus-2081	17	7	from	from	ADP
finefocus-2081	17	8	a	a	DET
finefocus-2081	17	9	niche	niche	NOUN
finefocus-2081	17	10	scientific	scientific	ADJ
finefocus-2081	17	11	field	field	NOUN
finefocus-2081	17	12	to	to	ADP
finefocus-2081	17	13	the	the	DET
finefocus-2081	17	14	laboratories	laboratory	NOUN
finefocus-2081	17	15	of	of	ADP
finefocus-2081	17	16	major	major	ADJ
finefocus-2081	17	17	research	research	NOUN
finefocus-2081	17	18	institutions	institution	NOUN
finefocus-2081	17	19	,	,	PUNCT
finefocus-2081	17	20	undergraduate	undergraduate	NOUN
finefocus-2081	17	21	classrooms	classroom	NOUN
finefocus-2081	17	22	,	,	PUNCT
finefocus-2081	17	23	and	and	CCONJ
finefocus-2081	17	24	popular	popular	ADJ
finefocus-2081	17	25	culture	culture	NOUN
finefocus-2081	17	26	.	.	PUNCT
finefocus-2081	18	1	in	in	ADP
finefocus-2081	18	2	the	the	DET
finefocus-2081	18	3	future	future	NOUN
finefocus-2081	18	4	,	,	PUNCT
finefocus-2081	18	5	crispr	crispr	PROPN
finefocus-2081	18	6	may	may	AUX
finefocus-2081	18	7	stand	stand	VERB
finefocus-2081	18	8	along	along	ADP
finefocus-2081	18	9	with	with	ADP
finefocus-2081	18	10	pcr	pcr	NOUN
finefocus-2081	18	11	,	,	PUNCT
finefocus-2081	18	12	dna	dna	NOUN
finefocus-2081	18	13	sequencing	sequencing	NOUN
finefocus-2081	18	14	,	,	PUNCT
finefocus-2081	18	15	and	and	CCONJ
finefocus-2081	18	16	transformation	transformation	NOUN
finefocus-2081	18	17	as	as	ADP
finefocus-2081	18	18	paradigm	paradigm	NOUN
finefocus-2081	18	19	shifting	shift	VERB
finefocus-2081	18	20	discoveries	discovery	NOUN
finefocus-2081	18	21	in	in	ADP
finefocus-2081	18	22	molecular	molecular	ADJ
finefocus-2081	18	23	biology	biology	NOUN
finefocus-2081	18	24	.	.	PUNCT
finefocus-2081	19	1	crispr	crispr	ADJ
finefocus-2081	19	2	genome	genome	NOUN
finefocus-2081	19	3	editing	editing	NOUN
finefocus-2081	19	4	is	be	AUX
finefocus-2081	19	5	technically	technically	ADV
finefocus-2081	19	6	uncomplicated	uncomplicated	ADJ
finefocus-2081	19	7	and	and	CCONJ
finefocus-2081	19	8	relatively	relatively	ADV
finefocus-2081	19	9	inexpensive	inexpensive	ADJ
finefocus-2081	19	10	.	.	PUNCT
finefocus-2081	20	1	thus	thus	ADV
finefocus-2081	20	2	,	,	PUNCT
finefocus-2081	20	3	crispr	crispr	NOUN
finefocus-2081	20	4	-	-	PUNCT
finefocus-2081	20	5	mediated	mediate	VERB
finefocus-2081	20	6	genome	genome	NOUN
finefocus-2081	20	7	editing	editing	NOUN
finefocus-2081	20	8	has	have	AUX
finefocus-2081	20	9	been	be	AUX
finefocus-2081	20	10	adopted	adopt	VERB
finefocus-2081	20	11	by	by	ADP
finefocus-2081	20	12	and	and	CCONJ
finefocus-2081	20	13	applied	apply	VERB
finefocus-2081	20	14	to	to	ADP
finefocus-2081	20	15	undergraduate	undergraduate	NOUN
finefocus-2081	20	16	curricula	curricula	NOUN
finefocus-2081	20	17	in	in	ADP
finefocus-2081	20	18	a	a	DET
finefocus-2081	20	19	wide	wide	ADJ
finefocus-2081	20	20	variety	variety	NOUN
finefocus-2081	20	21	of	of	ADP
finefocus-2081	20	22	ways	way	NOUN
finefocus-2081	20	23	.	.	PUNCT
finefocus-2081	21	1	in	in	ADP
finefocus-2081	21	2	this	this	DET
finefocus-2081	21	3	review	review	NOUN
finefocus-2081	21	4	,	,	PUNCT
finefocus-2081	21	5	we	we	PRON
finefocus-2081	21	6	provide	provide	VERB
finefocus-2081	21	7	an	an	DET
finefocus-2081	21	8	overview	overview	NOUN
finefocus-2081	21	9	of	of	ADP
finefocus-2081	21	10	crisprmediated	crisprmediate	VERB
finefocus-2081	21	11	genome	genome	NOUN
finefocus-2081	21	12	editing	editing	NOUN
finefocus-2081	21	13	and	and	CCONJ
finefocus-2081	21	14	examine	examine	VERB
finefocus-2081	21	15	some	some	PRON
finefocus-2081	21	16	of	of	ADP
finefocus-2081	21	17	the	the	DET
finefocus-2081	21	18	ways	way	NOUN
finefocus-2081	21	19	this	this	DET
finefocus-2081	21	20	technology	technology	NOUN
finefocus-2081	21	21	is	be	AUX
finefocus-2081	21	22	being	be	AUX
finefocus-2081	21	23	leveraged	leverage	VERB
finefocus-2081	21	24	to	to	PART
finefocus-2081	21	25	train	train	VERB
finefocus-2081	21	26	students	student	NOUN
finefocus-2081	21	27	in	in	ADP
finefocus-2081	21	28	the	the	DET
finefocus-2081	21	29	classroom	classroom	NOUN
finefocus-2081	21	30	and	and	CCONJ
finefocus-2081	21	31	laboratory	laboratory	NOUN
finefocus-2081	21	32	.	.	PUNCT
finefocus-2081	22	1	24	24	NUM
finefocus-2081	22	2	•	•	NUM
finefocus-2081	22	3	fine	fine	ADJ
finefocus-2081	22	4	focus	focus	NOUN
finefocus-2081	22	5	,	,	PUNCT
finefocus-2081	22	6	vol	vol	NOUN
finefocus-2081	22	7	5	5	NUM
finefocus-2081	22	8	2019	2019	NUM
finefocus-2081	22	9	crispr	crispr	ADJ
finefocus-2081	22	10	-	-	PUNCT
finefocus-2081	22	11	mediated	mediate	VERB
finefocus-2081	22	12	genome	genome	NOUN
finefocus-2081	22	13	editing	edit	VERB
finefocus-2081	22	14	the	the	DET
finefocus-2081	22	15	discovery	discovery	NOUN
finefocus-2081	22	16	that	that	PRON
finefocus-2081	22	17	crrna	crrna	VERB
finefocus-2081	22	18	guides	guide	NOUN
finefocus-2081	22	19	,	,	PUNCT
finefocus-2081	22	20	in	in	ADP
finefocus-2081	22	21	coordination	coordination	NOUN
finefocus-2081	22	22	with	with	ADP
finefocus-2081	22	23	cas	cas	PROPN
finefocus-2081	22	24	nuclease	nuclease	NOUN
finefocus-2081	22	25	mediate	mediate	VERB
finefocus-2081	22	26	viral	viral	ADJ
finefocus-2081	22	27	genome	genome	NOUN
finefocus-2081	22	28	cleavage	cleavage	NOUN
finefocus-2081	22	29	in	in	ADP
finefocus-2081	22	30	bacteria	bacteria	NOUN
finefocus-2081	22	31	provided	provide	VERB
finefocus-2081	22	32	an	an	DET
finefocus-2081	22	33	elegant	elegant	ADJ
finefocus-2081	22	34	method	method	NOUN
finefocus-2081	22	35	by	by	ADP
finefocus-2081	22	36	which	which	PRON
finefocus-2081	22	37	bacteria	bacteria	NOUN
finefocus-2081	22	38	defend	defend	VERB
finefocus-2081	22	39	themselves	themselves	PRON
finefocus-2081	22	40	from	from	ADP
finefocus-2081	22	41	viral	viral	ADJ
finefocus-2081	22	42	invasion	invasion	NOUN
finefocus-2081	22	43	.	.	PUNCT
finefocus-2081	23	1	this	this	DET
finefocus-2081	23	2	discovery	discovery	NOUN
finefocus-2081	23	3	however	however	ADV
finefocus-2081	23	4	begged	beg	VERB
finefocus-2081	23	5	the	the	DET
finefocus-2081	23	6	question	question	NOUN
finefocus-2081	23	7	,	,	PUNCT
finefocus-2081	23	8	could	could	AUX
finefocus-2081	23	9	this	this	DET
finefocus-2081	23	10	system	system	NOUN
finefocus-2081	23	11	cleave	cleave	VERB
finefocus-2081	23	12	dna	dna	PROPN
finefocus-2081	23	13	in	in	ADP
finefocus-2081	23	14	vitro	vitro	X
finefocus-2081	23	15	or	or	CCONJ
finefocus-2081	23	16	in	in	ADP
finefocus-2081	23	17	other	other	ADJ
finefocus-2081	23	18	organisms	organism	NOUN
finefocus-2081	23	19	?	?	PUNCT
finefocus-2081	24	1	investigators	investigator	NOUN
finefocus-2081	24	2	determined	determine	VERB
finefocus-2081	24	3	cas9	cas9	NOUN
finefocus-2081	24	4	,	,	PUNCT
finefocus-2081	24	5	crrna	crrna	VERB
finefocus-2081	24	6	,	,	PUNCT
finefocus-2081	24	7	and	and	CCONJ
finefocus-2081	24	8	tracrrna	tracrrna	NOUN
finefocus-2081	24	9	were	be	AUX
finefocus-2081	24	10	sufficient	sufficient	ADJ
finefocus-2081	24	11	to	to	PART
finefocus-2081	24	12	cleave	cleave	VERB
finefocus-2081	24	13	plasmid	plasmid	ADJ
finefocus-2081	24	14	dna	dna	NOUN
finefocus-2081	24	15	in	in	ADP
finefocus-2081	24	16	vitro	vitro	X
finefocus-2081	24	17	in	in	ADP
finefocus-2081	24	18	a	a	DET
finefocus-2081	24	19	sequence	sequence	NOUN
finefocus-2081	24	20	specific	specific	ADJ
finefocus-2081	24	21	manner	manner	NOUN
finefocus-2081	24	22	(	(	PUNCT
finefocus-2081	24	23	8)	8)	NUM
finefocus-2081	24	24	.	.	PUNCT
finefocus-2081	25	1	building	build	VERB
finefocus-2081	25	2	upon	upon	SCONJ
finefocus-2081	25	3	these	these	DET
finefocus-2081	25	4	results	result	NOUN
finefocus-2081	25	5	,	,	PUNCT
finefocus-2081	25	6	multiple	multiple	ADJ
finefocus-2081	25	7	investigators	investigator	NOUN
finefocus-2081	25	8	tested	test	VERB
finefocus-2081	25	9	and	and	CCONJ
finefocus-2081	25	10	found	find	VERB
finefocus-2081	25	11	cas9	cas9	PROPN
finefocus-2081	25	12	,	,	PUNCT
finefocus-2081	25	13	crrna	crrna	VERB
finefocus-2081	25	14	,	,	PUNCT
finefocus-2081	25	15	and	and	CCONJ
finefocus-2081	25	16	tracrrna	tracrrna	NOUN
finefocus-2081	25	17	could	could	AUX
finefocus-2081	25	18	cleave	cleave	VERB
finefocus-2081	25	19	dna	dna	PROPN
finefocus-2081	25	20	in	in	ADP
finefocus-2081	25	21	vivo	vivo	NOUN
finefocus-2081	25	22	in	in	ADP
finefocus-2081	25	23	organisms	organism	NOUN
finefocus-2081	25	24	other	other	ADJ
finefocus-2081	25	25	than	than	ADP
finefocus-2081	25	26	bacteria	bacteria	NOUN
finefocus-2081	25	27	including	include	VERB
finefocus-2081	25	28	mammalian	mammalian	ADJ
finefocus-2081	25	29	cells	cell	NOUN
finefocus-2081	25	30	(	(	PUNCT
finefocus-2081	25	31	10	10	NUM
finefocus-2081	25	32	-	-	SYM
finefocus-2081	25	33	12	12	NUM
finefocus-2081	25	34	)	)	PUNCT
finefocus-2081	25	35	.	.	PUNCT
finefocus-2081	26	1	this	this	DET
finefocus-2081	26	2	technique	technique	NOUN
finefocus-2081	26	3	is	be	AUX
finefocus-2081	26	4	now	now	ADV
finefocus-2081	26	5	commonly	commonly	ADV
finefocus-2081	26	6	referred	refer	VERB
finefocus-2081	26	7	to	to	ADP
finefocus-2081	26	8	as	as	ADP
finefocus-2081	26	9	crispr	crispr	NOUN
finefocus-2081	26	10	-	-	PUNCT
finefocus-2081	26	11	mediated	mediate	VERB
finefocus-2081	26	12	genome	genome	NOUN
finefocus-2081	26	13	cleavage	cleavage	NOUN
finefocus-2081	26	14	or	or	CCONJ
finefocus-2081	26	15	merely	merely	ADV
finefocus-2081	26	16	crispr	crispr	ADJ
finefocus-2081	26	17	.	.	PUNCT
finefocus-2081	27	1	for	for	ADP
finefocus-2081	27	2	crispr	crispr	NOUN
finefocus-2081	27	3	-	-	PUNCT
finefocus-2081	27	4	mediated	mediate	VERB
finefocus-2081	27	5	genome	genome	NOUN
finefocus-2081	27	6	cleavage	cleavage	NOUN
finefocus-2081	27	7	to	to	PART
finefocus-2081	27	8	occur	occur	VERB
finefocus-2081	27	9	,	,	PUNCT
finefocus-2081	27	10	a	a	DET
finefocus-2081	27	11	guide	guide	NOUN
finefocus-2081	27	12	rna	rna	NOUN
finefocus-2081	27	13	must	must	AUX
finefocus-2081	27	14	target	target	VERB
finefocus-2081	27	15	a	a	DET
finefocus-2081	27	16	cas9	cas9	NOUN
finefocus-2081	27	17	nuclease	nuclease	NOUN
finefocus-2081	27	18	to	to	ADP
finefocus-2081	27	19	a	a	DET
finefocus-2081	27	20	dna	dna	NOUN
finefocus-2081	27	21	sequence	sequence	NOUN
finefocus-2081	27	22	of	of	ADP
finefocus-2081	27	23	interest	interest	NOUN
finefocus-2081	27	24	.	.	PUNCT
finefocus-2081	28	1	however	however	ADV
finefocus-2081	28	2	,	,	PUNCT
finefocus-2081	28	3	once	once	SCONJ
finefocus-2081	28	4	cleavage	cleavage	NOUN
finefocus-2081	28	5	occurs	occur	VERB
finefocus-2081	28	6	it	it	PRON
finefocus-2081	28	7	is	be	AUX
finefocus-2081	28	8	critical	critical	ADJ
finefocus-2081	28	9	that	that	SCONJ
finefocus-2081	28	10	the	the	DET
finefocus-2081	28	11	host	host	NOUN
finefocus-2081	28	12	cell	cell	NOUN
finefocus-2081	28	13	’s	’s	PART
finefocus-2081	28	14	dna	dna	PROPN
finefocus-2081	28	15	repair	repair	NOUN
finefocus-2081	28	16	machinery	machinery	NOUN
finefocus-2081	28	17	efficiently	efficiently	ADV
finefocus-2081	28	18	repairs	repair	VERB
finefocus-2081	28	19	the	the	DET
finefocus-2081	28	20	dna	dna	PROPN
finefocus-2081	28	21	break	break	NOUN
finefocus-2081	28	22	or	or	CCONJ
finefocus-2081	28	23	the	the	DET
finefocus-2081	28	24	cell	cell	NOUN
finefocus-2081	28	25	will	will	AUX
finefocus-2081	28	26	die	die	VERB
finefocus-2081	28	27	.	.	PUNCT
finefocus-2081	29	1	dna	dna	PROPN
finefocus-2081	29	2	breaks	break	NOUN
finefocus-2081	29	3	are	be	AUX
finefocus-2081	29	4	repaired	repair	VERB
finefocus-2081	29	5	by	by	ADP
finefocus-2081	29	6	two	two	NUM
finefocus-2081	29	7	distinct	distinct	ADJ
finefocus-2081	29	8	mechanisms	mechanism	NOUN
finefocus-2081	29	9	.	.	PUNCT
finefocus-2081	30	1	nonhomologous	nonhomologous	ADJ
finefocus-2081	30	2	end	end	NOUN
finefocus-2081	30	3	joining	join	VERB
finefocus-2081	30	4	(	(	PUNCT
finefocus-2081	30	5	nhej	nhej	ADJ
finefocus-2081	30	6	)	)	PUNCT
finefocus-2081	30	7	,	,	PUNCT
finefocus-2081	30	8	reviewed	review	VERB
finefocus-2081	30	9	in	in	ADP
finefocus-2081	30	10	(	(	PUNCT
finefocus-2081	30	11	13	13	NUM
finefocus-2081	30	12	)	)	PUNCT
finefocus-2081	30	13	,	,	PUNCT
finefocus-2081	30	14	requires	require	VERB
finefocus-2081	30	15	that	that	SCONJ
finefocus-2081	30	16	the	the	DET
finefocus-2081	30	17	cleaved	cleaved	ADJ
finefocus-2081	30	18	ends	end	NOUN
finefocus-2081	30	19	of	of	ADP
finefocus-2081	30	20	the	the	DET
finefocus-2081	30	21	dna	dna	PROPN
finefocus-2081	30	22	are	be	AUX
finefocus-2081	30	23	trimmed	trim	VERB
finefocus-2081	30	24	(	(	PUNCT
finefocus-2081	30	25	figure	figure	NOUN
finefocus-2081	30	26	2	2	NUM
finefocus-2081	30	27	)	)	PUNCT
finefocus-2081	30	28	.	.	PUNCT
finefocus-2081	31	1	the	the	DET
finefocus-2081	31	2	ends	end	NOUN
finefocus-2081	31	3	are	be	AUX
finefocus-2081	31	4	then	then	ADV
finefocus-2081	31	5	joined	join	VERB
finefocus-2081	31	6	,	,	PUNCT
finefocus-2081	31	7	resulting	result	VERB
finefocus-2081	31	8	in	in	ADP
finefocus-2081	31	9	deletion	deletion	NOUN
finefocus-2081	31	10	of	of	ADP
finefocus-2081	31	11	the	the	DET
finefocus-2081	31	12	trimmed	trimmed	ADJ
finefocus-2081	31	13	sequence	sequence	NOUN
finefocus-2081	31	14	.	.	PUNCT
finefocus-2081	32	1	such	such	ADJ
finefocus-2081	32	2	deletions	deletion	NOUN
finefocus-2081	32	3	can	can	AUX
finefocus-2081	32	4	shift	shift	VERB
finefocus-2081	32	5	the	the	DET
finefocus-2081	32	6	reading	reading	NOUN
finefocus-2081	32	7	frame	frame	NOUN
finefocus-2081	32	8	causing	cause	VERB
finefocus-2081	32	9	premature	premature	ADJ
finefocus-2081	32	10	translation	translation	NOUN
finefocus-2081	32	11	termination	termination	NOUN
finefocus-2081	32	12	.	.	PUNCT
finefocus-2081	33	1	homologous	homologous	ADJ
finefocus-2081	33	2	recombination	recombination	NOUN
finefocus-2081	33	3	(	(	PUNCT
finefocus-2081	33	4	hr	hr	NOUN
finefocus-2081	33	5	)	)	PUNCT
finefocus-2081	33	6	,	,	PUNCT
finefocus-2081	33	7	reviewed	review	VERB
finefocus-2081	33	8	in	in	ADP
finefocus-2081	33	9	(	(	PUNCT
finefocus-2081	33	10	14	14	NUM
finefocus-2081	33	11	)	)	PUNCT
finefocus-2081	33	12	,	,	PUNCT
finefocus-2081	33	13	is	be	AUX
finefocus-2081	33	14	another	another	DET
finefocus-2081	33	15	mechanism	mechanism	NOUN
finefocus-2081	33	16	used	use	VERB
finefocus-2081	33	17	to	to	PART
finefocus-2081	33	18	repair	repair	VERB
finefocus-2081	33	19	cas9	cas9	NOUN
finefocus-2081	33	20	-	-	PUNCT
finefocus-2081	33	21	mediated	mediate	VERB
finefocus-2081	33	22	cleavage	cleavage	NOUN
finefocus-2081	33	23	.	.	PUNCT
finefocus-2081	34	1	during	during	ADP
finefocus-2081	34	2	hr	hr	NOUN
finefocus-2081	34	3	cells	cell	NOUN
finefocus-2081	34	4	use	use	VERB
finefocus-2081	34	5	a	a	DET
finefocus-2081	34	6	homologous	homologous	ADJ
finefocus-2081	34	7	dna	dna	NOUN
finefocus-2081	34	8	sequence	sequence	NOUN
finefocus-2081	34	9	to	to	PART
finefocus-2081	34	10	repair	repair	VERB
finefocus-2081	34	11	the	the	DET
finefocus-2081	34	12	cut	cut	NOUN
finefocus-2081	34	13	site	site	NOUN
finefocus-2081	34	14	.	.	PUNCT
finefocus-2081	35	1	dna	dna	PROPN
finefocus-2081	35	2	encoding	encode	VERB
finefocus-2081	35	3	a	a	DET
finefocus-2081	35	4	desired	desire	VERB
finefocus-2081	35	5	genome	genome	NOUN
finefocus-2081	35	6	edit	edit	NOUN
finefocus-2081	35	7	,	,	PUNCT
finefocus-2081	35	8	the	the	DET
finefocus-2081	35	9	repair	repair	NOUN
finefocus-2081	35	10	template	template	NOUN
finefocus-2081	35	11	,	,	PUNCT
finefocus-2081	35	12	is	be	AUX
finefocus-2081	35	13	cotransformed	cotransforme	VERB
finefocus-2081	35	14	with	with	ADP
finefocus-2081	35	15	the	the	DET
finefocus-2081	35	16	cas9	cas9	NOUN
finefocus-2081	35	17	nuclease	nuclease	NOUN
finefocus-2081	35	18	and	and	CCONJ
finefocus-2081	35	19	guide	guide	VERB
finefocus-2081	35	20	rna	rna	PROPN
finefocus-2081	35	21	.	.	PUNCT
finefocus-2081	36	1	when	when	SCONJ
finefocus-2081	36	2	the	the	DET
finefocus-2081	36	3	cell	cell	NOUN
finefocus-2081	36	4	uses	use	VERB
finefocus-2081	36	5	the	the	DET
finefocus-2081	36	6	repair	repair	NOUN
finefocus-2081	36	7	template	template	NOUN
finefocus-2081	36	8	to	to	PART
finefocus-2081	36	9	fix	fix	VERB
finefocus-2081	36	10	the	the	DET
finefocus-2081	36	11	cleaved	cleaved	ADJ
finefocus-2081	36	12	dna	dna	NOUN
finefocus-2081	36	13	,	,	PUNCT
finefocus-2081	36	14	changes	change	NOUN
finefocus-2081	36	15	encoded	encode	VERB
finefocus-2081	36	16	by	by	ADP
finefocus-2081	36	17	repair	repair	NOUN
finefocus-2081	36	18	template	template	NOUN
finefocus-2081	36	19	are	be	AUX
finefocus-2081	36	20	introduced	introduce	VERB
finefocus-2081	36	21	at	at	ADP
finefocus-2081	36	22	the	the	DET
finefocus-2081	36	23	site	site	NOUN
finefocus-2081	36	24	of	of	ADP
finefocus-2081	36	25	cleavage	cleavage	NOUN
finefocus-2081	36	26	(	(	PUNCT
finefocus-2081	36	27	figure	figure	NOUN
finefocus-2081	36	28	2	2	NUM
finefocus-2081	36	29	)	)	PUNCT
finefocus-2081	36	30	.	.	PUNCT
finefocus-2081	37	1	thus	thus	ADV
finefocus-2081	37	2	by	by	ADP
finefocus-2081	37	3	designing	design	VERB
finefocus-2081	37	4	the	the	DET
finefocus-2081	37	5	sequence	sequence	NOUN
finefocus-2081	37	6	of	of	ADP
finefocus-2081	37	7	the	the	DET
finefocus-2081	37	8	repair	repair	NOUN
finefocus-2081	37	9	template	template	NOUN
finefocus-2081	37	10	,	,	PUNCT
finefocus-2081	37	11	the	the	DET
finefocus-2081	37	12	investigator	investigator	NOUN
finefocus-2081	37	13	can	can	AUX
finefocus-2081	37	14	precisely	precisely	ADV
finefocus-2081	37	15	edit	edit	VERB
finefocus-2081	37	16	the	the	DET
finefocus-2081	37	17	genome	genome	NOUN
finefocus-2081	37	18	,	,	PUNCT
finefocus-2081	37	19	introducing	introduce	VERB
finefocus-2081	37	20	desired	desire	VERB
finefocus-2081	37	21	point	point	NOUN
finefocus-2081	37	22	mutations	mutation	NOUN
finefocus-2081	37	23	,	,	PUNCT
finefocus-2081	37	24	insertions	insertion	NOUN
finefocus-2081	37	25	,	,	PUNCT
finefocus-2081	37	26	or	or	CCONJ
finefocus-2081	37	27	deletions	deletion	NOUN
finefocus-2081	37	28	.	.	PUNCT
finefocus-2081	38	1	such	such	ADJ
finefocus-2081	38	2	precise	precise	ADJ
finefocus-2081	38	3	changes	change	NOUN
finefocus-2081	38	4	are	be	AUX
finefocus-2081	38	5	commonly	commonly	ADV
finefocus-2081	38	6	referred	refer	VERB
finefocus-2081	38	7	to	to	ADP
finefocus-2081	38	8	as	as	ADP
finefocus-2081	38	9	crisprmediated	crisprmediate	VERB
finefocus-2081	38	10	genome	genome	NOUN
finefocus-2081	38	11	editing	editing	NOUN
finefocus-2081	38	12	.	.	PUNCT
finefocus-2081	39	1	a	a	DET
finefocus-2081	39	2	number	number	NOUN
finefocus-2081	39	3	of	of	ADP
finefocus-2081	39	4	nucleases	nuclease	NOUN
finefocus-2081	39	5	can	can	AUX
finefocus-2081	39	6	be	be	AUX
finefocus-2081	39	7	used	use	VERB
finefocus-2081	39	8	to	to	PART
finefocus-2081	39	9	perform	perform	VERB
finefocus-2081	39	10	genome	genome	NOUN
finefocus-2081	39	11	cleavage	cleavage	NOUN
finefocus-2081	39	12	,	,	PUNCT
finefocus-2081	39	13	and	and	CCONJ
finefocus-2081	39	14	these	these	DET
finefocus-2081	39	15	nucleases	nuclease	NOUN
finefocus-2081	39	16	have	have	VERB
finefocus-2081	39	17	distinct	distinct	ADJ
finefocus-2081	39	18	requirements	requirement	NOUN
finefocus-2081	39	19	.	.	PUNCT
finefocus-2081	40	1	for	for	ADP
finefocus-2081	40	2	instance	instance	NOUN
finefocus-2081	40	3	,	,	PUNCT
finefocus-2081	40	4	cas9	cas9	NOUN
finefocus-2081	40	5	nuclease	nuclease	NOUN
finefocus-2081	40	6	requires	require	VERB
finefocus-2081	40	7	a	a	DET
finefocus-2081	40	8	tracrrna	tracrrna	NOUN
finefocus-2081	40	9	as	as	ADV
finefocus-2081	40	10	well	well	ADV
finefocus-2081	40	11	as	as	ADP
finefocus-2081	40	12	guide	guide	VERB
finefocus-2081	40	13	rna	rna	NOUN
finefocus-2081	40	14	to	to	PART
finefocus-2081	40	15	mediate	mediate	VERB
finefocus-2081	40	16	cleavage	cleavage	NOUN
finefocus-2081	40	17	(	(	PUNCT
finefocus-2081	40	18	6	6	NUM
finefocus-2081	40	19	,	,	PUNCT
finefocus-2081	40	20	9	9	NUM
finefocus-2081	40	21	)	)	PUNCT
finefocus-2081	40	22	,	,	PUNCT
finefocus-2081	40	23	while	while	SCONJ
finefocus-2081	40	24	cpf1	cpf1	PROPN
finefocus-2081	40	25	,	,	PUNCT
finefocus-2081	40	26	another	another	DET
finefocus-2081	40	27	cas	cas	NOUN
finefocus-2081	40	28	nuclease	nuclease	NOUN
finefocus-2081	40	29	,	,	PUNCT
finefocus-2081	40	30	does	do	AUX
finefocus-2081	40	31	not	not	PART
finefocus-2081	40	32	require	require	VERB
finefocus-2081	40	33	tracrrna	tracrrna	NOUN
finefocus-2081	40	34	(	(	PUNCT
finefocus-2081	40	35	15	15	NUM
finefocus-2081	40	36	)	)	PUNCT
finefocus-2081	40	37	.	.	PUNCT
finefocus-2081	41	1	cas9	cas9	NOUN
finefocus-2081	41	2	and	and	CCONJ
finefocus-2081	41	3	cpf1	cpf1	NOUN
finefocus-2081	41	4	also	also	ADV
finefocus-2081	41	5	use	use	VERB
finefocus-2081	41	6	distinct	distinct	ADJ
finefocus-2081	41	7	pam	pam	NOUN
finefocus-2081	41	8	sequences	sequence	NOUN
finefocus-2081	41	9	and	and	CCONJ
finefocus-2081	41	10	cut	cut	VERB
finefocus-2081	41	11	at	at	ADP
finefocus-2081	41	12	different	different	ADJ
finefocus-2081	41	13	lengths	length	NOUN
finefocus-2081	41	14	away	away	ADV
finefocus-2081	41	15	from	from	ADP
finefocus-2081	41	16	their	their	PRON
finefocus-2081	41	17	pam	pam	NOUN
finefocus-2081	41	18	sequence	sequence	NOUN
finefocus-2081	41	19	.	.	PUNCT
finefocus-2081	42	1	in	in	ADP
finefocus-2081	42	2	addition	addition	NOUN
finefocus-2081	42	3	to	to	ADP
finefocus-2081	42	4	genome	genome	NOUN
finefocus-2081	42	5	editing	editing	NOUN
finefocus-2081	42	6	,	,	PUNCT
finefocus-2081	42	7	cas9	cas9	NOUN
finefocus-2081	42	8	can	can	AUX
finefocus-2081	42	9	be	be	AUX
finefocus-2081	42	10	used	use	VERB
finefocus-2081	42	11	to	to	PART
finefocus-2081	42	12	alter	alter	VERB
finefocus-2081	42	13	gene	gene	NOUN
finefocus-2081	42	14	expression	expression	NOUN
finefocus-2081	42	15	by	by	ADP
finefocus-2081	42	16	creating	create	VERB
finefocus-2081	42	17	a	a	DET
finefocus-2081	42	18	gene	gene	NOUN
finefocus-2081	42	19	fusion	fusion	NOUN
finefocus-2081	42	20	a	a	DET
finefocus-2081	42	21	transcriptional	transcriptional	ADJ
finefocus-2081	42	22	activator	activator	NOUN
finefocus-2081	42	23	or	or	CCONJ
finefocus-2081	42	24	repressor	repressor	NOUN
finefocus-2081	42	25	to	to	ADP
finefocus-2081	42	26	catalytically	catalytically	ADV
finefocus-2081	42	27	active	active	ADJ
finefocus-2081	42	28	cas9	cas9	NOUN
finefocus-2081	42	29	and	and	CCONJ
finefocus-2081	42	30	targeting	target	VERB
finefocus-2081	42	31	these	these	DET
finefocus-2081	42	32	complexes	complex	NOUN
finefocus-2081	42	33	to	to	ADP
finefocus-2081	42	34	the	the	DET
finefocus-2081	42	35	gene	gene	NOUN
finefocus-2081	42	36	of	of	ADP
finefocus-2081	42	37	interest	interest	NOUN
finefocus-2081	42	38	(	(	PUNCT
finefocus-2081	42	39	16	16	NUM
finefocus-2081	42	40	)	)	PUNCT
finefocus-2081	42	41	.	.	PUNCT
finefocus-2081	43	1	furthermore	furthermore	ADV
finefocus-2081	43	2	,	,	PUNCT
finefocus-2081	43	3	inactive	inactive	ADJ
finefocus-2081	43	4	cas9	cas9	NOUN
finefocus-2081	43	5	nuclease	nuclease	NOUN
finefocus-2081	43	6	has	have	AUX
finefocus-2081	43	7	been	be	AUX
finefocus-2081	43	8	used	use	VERB
finefocus-2081	43	9	to	to	PART
finefocus-2081	43	10	fluorescently	fluorescently	ADV
finefocus-2081	43	11	label	label	VERB
finefocus-2081	43	12	the	the	DET
finefocus-2081	43	13	genomic	genomic	ADJ
finefocus-2081	43	14	loci	locus	NOUN
finefocus-2081	43	15	enabling	enable	VERB
finefocus-2081	43	16	investigation	investigation	NOUN
finefocus-2081	43	17	of	of	ADP
finefocus-2081	43	18	the	the	DET
finefocus-2081	43	19	3d	3d	ADJ
finefocus-2081	43	20	architecture	architecture	NOUN
finefocus-2081	43	21	of	of	ADP
finefocus-2081	43	22	the	the	DET
finefocus-2081	43	23	nucleus	nucleus	NOUN
finefocus-2081	43	24	(	(	PUNCT
finefocus-2081	43	25	17	17	NUM
finefocus-2081	43	26	)	)	PUNCT
finefocus-2081	43	27	.	.	PUNCT
finefocus-2081	44	1	these	these	DET
finefocus-2081	44	2	discoveries	discovery	NOUN
finefocus-2081	44	3	have	have	AUX
finefocus-2081	44	4	fundamentally	fundamentally	ADV
finefocus-2081	44	5	changed	change	VERB
finefocus-2081	44	6	the	the	DET
finefocus-2081	44	7	field	field	NOUN
finefocus-2081	44	8	of	of	ADP
finefocus-2081	44	9	biology	biology	NOUN
finefocus-2081	44	10	allowing	allow	VERB
finefocus-2081	44	11	researchers	researcher	NOUN
finefocus-2081	44	12	unprecedented	unprecedented	ADJ
finefocus-2081	44	13	flexibility	flexibility	NOUN
finefocus-2081	44	14	to	to	PART
finefocus-2081	44	15	manipulate	manipulate	VERB
finefocus-2081	44	16	an	an	DET
finefocus-2081	44	17	organism	organism	NOUN
finefocus-2081	44	18	’s	’s	PART
finefocus-2081	44	19	genome	genome	NOUN
finefocus-2081	44	20	and	and	CCONJ
finefocus-2081	44	21	transcriptome	transcriptome	NOUN
finefocus-2081	44	22	.	.	PUNCT
finefocus-2081	45	1	figure	figure	NOUN
finefocus-2081	45	2	1	1	NUM
finefocus-2081	45	3	.	.	X
finefocus-2081	45	4	crispr	crispr	PROPN
finefocus-2081	45	5	is	be	AUX
finefocus-2081	45	6	used	use	VERB
finefocus-2081	45	7	by	by	ADP
finefocus-2081	45	8	bacteria	bacteria	NOUN
finefocus-2081	45	9	to	to	PART
finefocus-2081	45	10	cleave	cleave	VERB
finefocus-2081	45	11	viral	viral	ADJ
finefocus-2081	45	12	dna	dna	NOUN
finefocus-2081	45	13	.	.	PUNCT
finefocus-2081	46	1	crrna	crrna	PROPN
finefocus-2081	46	2	is	be	AUX
finefocus-2081	46	3	yellow	yellow	ADJ
finefocus-2081	46	4	and	and	CCONJ
finefocus-2081	46	5	navy	navy	PROPN
finefocus-2081	46	6	blue	blue	NOUN
finefocus-2081	46	7	.	.	PUNCT
finefocus-2081	47	1	tracrrna	tracrrna	NOUN
finefocus-2081	47	2	is	be	AUX
finefocus-2081	47	3	in	in	ADP
finefocus-2081	47	4	green	green	ADJ
finefocus-2081	47	5	.	.	PUNCT
finefocus-2081	48	1	crispr	crispr	ADJ
finefocus-2081	48	2	•	•	NOUN
finefocus-2081	48	3	25	25	NUM
finefocus-2081	48	4	figure	figure	NOUN
finefocus-2081	48	5	2	2	NUM
finefocus-2081	48	6	.	.	X
finefocus-2081	48	7	dna	dna	PROPN
finefocus-2081	48	8	cleaved	cleave	VERB
finefocus-2081	48	9	by	by	ADP
finefocus-2081	48	10	cas9	cas9	PROPN
finefocus-2081	48	11	is	be	AUX
finefocus-2081	48	12	repaired	repair	VERB
finefocus-2081	48	13	by	by	ADP
finefocus-2081	48	14	either	either	CCONJ
finefocus-2081	48	15	nonhomologous	nonhomologous	ADJ
finefocus-2081	48	16	end	end	NOUN
finefocus-2081	48	17	joining	join	VERB
finefocus-2081	48	18	or	or	CCONJ
finefocus-2081	48	19	homologous	homologous	ADJ
finefocus-2081	48	20	recombination	recombination	NOUN
finefocus-2081	48	21	.	.	PUNCT
finefocus-2081	49	1	pam	pam	NOUN
finefocus-2081	49	2	site	site	NOUN
finefocus-2081	49	3	is	be	AUX
finefocus-2081	49	4	red	red	ADJ
finefocus-2081	49	5	.	.	PUNCT
finefocus-2081	50	1	26	26	NUM
finefocus-2081	50	2	•	•	NUM
finefocus-2081	50	3	fine	fine	ADJ
finefocus-2081	50	4	focus	focus	NOUN
finefocus-2081	50	5	,	,	PUNCT
finefocus-2081	50	6	vol	vol	NOUN
finefocus-2081	50	7	5	5	NUM
finefocus-2081	50	8	2019	2019	NUM
finefocus-2081	50	9	has	have	VERB
finefocus-2081	50	10	the	the	DET
finefocus-2081	50	11	potential	potential	NOUN
finefocus-2081	50	12	to	to	PART
finefocus-2081	50	13	cause	cause	VERB
finefocus-2081	50	14	unforeseen	unforeseen	ADJ
finefocus-2081	50	15	consequences	consequence	NOUN
finefocus-2081	50	16	.	.	PUNCT
finefocus-2081	51	1	beyond	beyond	ADP
finefocus-2081	51	2	regulating	regulate	VERB
finefocus-2081	51	3	the	the	DET
finefocus-2081	51	4	spread	spread	NOUN
finefocus-2081	51	5	of	of	ADP
finefocus-2081	51	6	disease	disease	NOUN
finefocus-2081	51	7	,	,	PUNCT
finefocus-2081	51	8	increased	increase	VERB
finefocus-2081	51	9	genetic	genetic	ADJ
finefocus-2081	51	10	engineering	engineering	NOUN
finefocus-2081	51	11	efficiency	efficiency	NOUN
finefocus-2081	51	12	via	via	ADP
finefocus-2081	51	13	crispr	crispr	ADJ
finefocus-2081	51	14	enables	enable	VERB
finefocus-2081	51	15	investigators	investigator	NOUN
finefocus-2081	51	16	to	to	ADP
finefocus-2081	51	17	better	well	ADJ
finefocus-2081	51	18	model	model	NOUN
finefocus-2081	51	19	diseases	disease	NOUN
finefocus-2081	51	20	in	in	ADP
finefocus-2081	51	21	vivo	vivo	NOUN
finefocus-2081	51	22	(	(	PUNCT
finefocus-2081	51	23	42	42	NUM
finefocus-2081	51	24	-	-	SYM
finefocus-2081	51	25	44	44	NUM
finefocus-2081	51	26	)	)	PUNCT
finefocus-2081	51	27	.	.	PUNCT
finefocus-2081	52	1	unlike	unlike	ADP
finefocus-2081	52	2	transplant	transplant	NOUN
finefocus-2081	52	3	or	or	CCONJ
finefocus-2081	52	4	in	in	ADP
finefocus-2081	52	5	vitro	vitro	X
finefocus-2081	52	6	experiments	experiment	NOUN
finefocus-2081	52	7	,	,	PUNCT
finefocus-2081	52	8	crisprcas9	crisprcas9	NOUN
finefocus-2081	52	9	can	can	AUX
finefocus-2081	52	10	be	be	AUX
finefocus-2081	52	11	used	use	VERB
finefocus-2081	52	12	to	to	PART
finefocus-2081	52	13	introduce	introduce	VERB
finefocus-2081	52	14	a	a	DET
finefocus-2081	52	15	specific	specific	ADJ
finefocus-2081	52	16	genotype	genotype	NOUN
finefocus-2081	52	17	.	.	PUNCT
finefocus-2081	53	1	this	this	PRON
finefocus-2081	53	2	is	be	AUX
finefocus-2081	53	3	ideal	ideal	ADJ
finefocus-2081	53	4	for	for	ADP
finefocus-2081	53	5	studying	study	VERB
finefocus-2081	53	6	disease	disease	NOUN
finefocus-2081	53	7	progression	progression	NOUN
finefocus-2081	53	8	and	and	CCONJ
finefocus-2081	53	9	variability	variability	NOUN
finefocus-2081	53	10	,	,	PUNCT
finefocus-2081	53	11	as	as	SCONJ
finefocus-2081	53	12	such	such	ADJ
finefocus-2081	53	13	studies	study	NOUN
finefocus-2081	53	14	more	more	ADV
finefocus-2081	53	15	closely	closely	ADV
finefocus-2081	53	16	maintain	maintain	VERB
finefocus-2081	53	17	tissue	tissue	NOUN
finefocus-2081	53	18	microenvironments	microenvironment	NOUN
finefocus-2081	53	19	and	and	CCONJ
finefocus-2081	53	20	can	can	AUX
finefocus-2081	53	21	be	be	AUX
finefocus-2081	53	22	performed	perform	VERB
finefocus-2081	53	23	in	in	ADP
finefocus-2081	53	24	fully	fully	ADV
finefocus-2081	53	25	immunocompetent	immunocompetent	ADJ
finefocus-2081	53	26	animals	animal	NOUN
finefocus-2081	53	27	(	(	PUNCT
finefocus-2081	53	28	45	45	NUM
finefocus-2081	53	29	)	)	PUNCT
finefocus-2081	53	30	.	.	PUNCT
finefocus-2081	54	1	genome	genome	NOUN
finefocus-2081	54	2	editing	edit	VERB
finefocus-2081	54	3	systems	system	NOUN
finefocus-2081	54	4	in	in	ADP
finefocus-2081	54	5	human	human	ADJ
finefocus-2081	54	6	pathogens	pathogen	NOUN
finefocus-2081	54	7	such	such	ADJ
finefocus-2081	54	8	as	as	ADP
finefocus-2081	54	9	trypanosoma	trypanosoma	PROPN
finefocus-2081	54	10	brucei	brucei	PROPN
finefocus-2081	54	11	(	(	PUNCT
finefocus-2081	54	12	46	46	NUM
finefocus-2081	54	13	,	,	PUNCT
finefocus-2081	54	14	47	47	NUM
finefocus-2081	54	15	)	)	PUNCT
finefocus-2081	54	16	or	or	CCONJ
finefocus-2081	54	17	c.	c.	NOUN
finefocus-2081	54	18	albicans	albican	NOUN
finefocus-2081	54	19	(	(	PUNCT
finefocus-2081	54	20	21	21	NUM
finefocus-2081	54	21	)	)	PUNCT
finefocus-2081	54	22	may	may	AUX
finefocus-2081	54	23	enable	enable	VERB
finefocus-2081	54	24	researchers	researcher	NOUN
finefocus-2081	54	25	to	to	PART
finefocus-2081	54	26	identify	identify	VERB
finefocus-2081	54	27	new	new	ADJ
finefocus-2081	54	28	therapeutic	therapeutic	ADJ
finefocus-2081	54	29	targets	target	NOUN
finefocus-2081	54	30	.	.	PUNCT
finefocus-2081	55	1	collectively	collectively	ADV
finefocus-2081	55	2	,	,	PUNCT
finefocus-2081	55	3	these	these	DET
finefocus-2081	55	4	models	model	NOUN
finefocus-2081	55	5	have	have	VERB
finefocus-2081	55	6	the	the	DET
finefocus-2081	55	7	power	power	NOUN
finefocus-2081	55	8	to	to	PART
finefocus-2081	55	9	open	open	VERB
finefocus-2081	55	10	doors	door	NOUN
finefocus-2081	55	11	to	to	ADP
finefocus-2081	55	12	new	new	ADJ
finefocus-2081	55	13	therapies	therapy	NOUN
finefocus-2081	55	14	and	and	CCONJ
finefocus-2081	55	15	a	a	DET
finefocus-2081	55	16	better	well	ADJ
finefocus-2081	55	17	understanding	understanding	NOUN
finefocus-2081	55	18	of	of	ADP
finefocus-2081	55	19	human	human	ADJ
finefocus-2081	55	20	health	health	NOUN
finefocus-2081	55	21	.	.	PUNCT
finefocus-2081	56	1	finally	finally	ADV
finefocus-2081	56	2	,	,	PUNCT
finefocus-2081	56	3	crispr	crispr	NOUN
finefocus-2081	56	4	-	-	PUNCT
finefocus-2081	56	5	mediated	mediate	VERB
finefocus-2081	56	6	genome	genome	NOUN
finefocus-2081	56	7	editing	editing	NOUN
finefocus-2081	56	8	could	could	AUX
finefocus-2081	56	9	be	be	AUX
finefocus-2081	56	10	used	use	VERB
finefocus-2081	56	11	to	to	PART
finefocus-2081	56	12	alter	alter	VERB
finefocus-2081	56	13	the	the	DET
finefocus-2081	56	14	human	human	ADJ
finefocus-2081	56	15	genome	genome	NOUN
finefocus-2081	56	16	to	to	PART
finefocus-2081	56	17	improve	improve	VERB
finefocus-2081	56	18	health	health	NOUN
finefocus-2081	56	19	and	and	CCONJ
finefocus-2081	56	20	change	change	NOUN
finefocus-2081	56	21	phenotype	phenotype	NOUN
finefocus-2081	56	22	(	(	PUNCT
finefocus-2081	56	23	48	48	NUM
finefocus-2081	56	24	)	)	PUNCT
finefocus-2081	56	25	.	.	PUNCT
finefocus-2081	57	1	while	while	SCONJ
finefocus-2081	57	2	crispr	crispr	NOUN
finefocus-2081	57	3	-	-	PUNCT
finefocus-2081	57	4	mediated	mediate	VERB
finefocus-2081	57	5	genome	genome	NOUN
finefocus-2081	57	6	editing	editing	NOUN
finefocus-2081	57	7	has	have	VERB
finefocus-2081	57	8	the	the	DET
finefocus-2081	57	9	potential	potential	NOUN
finefocus-2081	57	10	to	to	PART
finefocus-2081	57	11	improve	improve	VERB
finefocus-2081	57	12	human	human	ADJ
finefocus-2081	57	13	health	health	NOUN
finefocus-2081	57	14	in	in	ADP
finefocus-2081	57	15	a	a	DET
finefocus-2081	57	16	variety	variety	NOUN
finefocus-2081	57	17	of	of	ADP
finefocus-2081	57	18	ways	way	NOUN
finefocus-2081	57	19	many	many	ADJ
finefocus-2081	57	20	such	such	ADJ
finefocus-2081	57	21	applications	application	NOUN
finefocus-2081	57	22	are	be	AUX
finefocus-2081	57	23	provocative	provocative	ADJ
finefocus-2081	57	24	and	and	CCONJ
finefocus-2081	57	25	controversial	controversial	ADJ
finefocus-2081	57	26	.	.	PUNCT
finefocus-2081	58	1	the	the	DET
finefocus-2081	58	2	scientific	scientific	ADJ
finefocus-2081	58	3	community	community	NOUN
finefocus-2081	58	4	and	and	CCONJ
finefocus-2081	58	5	public	public	NOUN
finefocus-2081	58	6	must	must	AUX
finefocus-2081	58	7	wrestle	wrestle	VERB
finefocus-2081	58	8	with	with	ADP
finefocus-2081	58	9	not	not	PART
finefocus-2081	58	10	only	only	ADV
finefocus-2081	58	11	the	the	DET
finefocus-2081	58	12	technical	technical	ADJ
finefocus-2081	58	13	but	but	CCONJ
finefocus-2081	58	14	ethical	ethical	ADJ
finefocus-2081	58	15	challenges	challenge	NOUN
finefocus-2081	58	16	presented	present	VERB
finefocus-2081	58	17	by	by	ADP
finefocus-2081	58	18	such	such	ADJ
finefocus-2081	58	19	avenues	avenue	NOUN
finefocus-2081	58	20	of	of	ADP
finefocus-2081	58	21	investigation	investigation	NOUN
finefocus-2081	58	22	(	(	PUNCT
finefocus-2081	58	23	49	49	NUM
finefocus-2081	58	24	)	)	PUNCT
finefocus-2081	58	25	.	.	PUNCT
finefocus-2081	59	1	these	these	DET
finefocus-2081	59	2	potential	potential	ADJ
finefocus-2081	59	3	applications	application	NOUN
finefocus-2081	59	4	can	can	AUX
finefocus-2081	59	5	bring	bring	VERB
finefocus-2081	59	6	about	about	ADP
finefocus-2081	59	7	significant	significant	ADJ
finefocus-2081	59	8	technical	technical	ADJ
finefocus-2081	59	9	challenges	challenge	NOUN
finefocus-2081	59	10	and	and	CCONJ
finefocus-2081	59	11	require	require	VERB
finefocus-2081	59	12	students	student	NOUN
finefocus-2081	59	13	balance	balance	VERB
finefocus-2081	59	14	complex	complex	ADJ
finefocus-2081	59	15	ethical	ethical	ADJ
finefocus-2081	59	16	considerations	consideration	NOUN
finefocus-2081	59	17	as	as	ADV
finefocus-2081	59	18	well	well	ADV
finefocus-2081	59	19	.	.	PUNCT
finefocus-2081	60	1	as	as	ADP
finefocus-2081	60	2	such	such	ADJ
finefocus-2081	60	3	,	,	PUNCT
finefocus-2081	60	4	it	it	PRON
finefocus-2081	60	5	is	be	AUX
finefocus-2081	60	6	imperative	imperative	ADJ
finefocus-2081	60	7	students	student	NOUN
finefocus-2081	60	8	are	be	AUX
finefocus-2081	60	9	exposed	expose	VERB
finefocus-2081	60	10	to	to	ADP
finefocus-2081	60	11	genome	genome	NOUN
finefocus-2081	60	12	editing	editing	NOUN
finefocus-2081	60	13	technology	technology	NOUN
finefocus-2081	60	14	during	during	ADP
finefocus-2081	60	15	their	their	PRON
finefocus-2081	60	16	undergraduate	undergraduate	ADJ
finefocus-2081	60	17	education	education	NOUN
finefocus-2081	60	18	.	.	PUNCT
finefocus-2081	61	1	this	this	DET
finefocus-2081	61	2	exposure	exposure	NOUN
finefocus-2081	61	3	will	will	AUX
finefocus-2081	61	4	provide	provide	VERB
finefocus-2081	61	5	students	student	NOUN
finefocus-2081	61	6	the	the	DET
finefocus-2081	61	7	best	good	ADJ
finefocus-2081	61	8	opportunity	opportunity	NOUN
finefocus-2081	61	9	to	to	PART
finefocus-2081	61	10	efficiently	efficiently	ADV
finefocus-2081	61	11	and	and	CCONJ
finefocus-2081	61	12	responsibly	responsibly	ADV
finefocus-2081	61	13	apply	apply	VERB
finefocus-2081	61	14	crispr	crispr	ADJ
finefocus-2081	61	15	technology	technology	NOUN
finefocus-2081	61	16	to	to	ADP
finefocus-2081	61	17	important	important	ADJ
finefocus-2081	61	18	research	research	NOUN
finefocus-2081	61	19	problems	problem	NOUN
finefocus-2081	61	20	.	.	PUNCT
finefocus-2081	62	1	these	these	DET
finefocus-2081	62	2	experiences	experience	NOUN
finefocus-2081	62	3	can	can	AUX
finefocus-2081	62	4	come	come	VERB
finefocus-2081	62	5	in	in	ADP
finefocus-2081	62	6	a	a	DET
finefocus-2081	62	7	variety	variety	NOUN
finefocus-2081	62	8	of	of	ADP
finefocus-2081	62	9	forms	form	NOUN
finefocus-2081	62	10	(	(	PUNCT
finefocus-2081	62	11	50	50	NUM
finefocus-2081	62	12	)	)	PUNCT
finefocus-2081	62	13	.	.	PUNCT
finefocus-2081	63	1	how	how	SCONJ
finefocus-2081	63	2	crispr	crispr	NOUN
finefocus-2081	63	3	is	be	AUX
finefocus-2081	63	4	being	be	AUX
finefocus-2081	63	5	applied	apply	VERB
finefocus-2081	63	6	to	to	PART
finefocus-2081	63	7	undergraduate	undergraduate	VERB
finefocus-2081	63	8	education	education	NOUN
finefocus-2081	63	9	crispr	crispr	NOUN
finefocus-2081	63	10	mediated	mediate	VERB
finefocus-2081	63	11	genome	genome	NOUN
finefocus-2081	63	12	editing	editing	NOUN
finefocus-2081	63	13	becomes	become	VERB
finefocus-2081	63	14	widespread	widespread	ADJ
finefocus-2081	63	15	the	the	DET
finefocus-2081	63	16	groundbreaking	groundbreake	VERB
finefocus-2081	63	17	realization	realization	NOUN
finefocus-2081	63	18	that	that	SCONJ
finefocus-2081	63	19	crispr	crispr	ADJ
finefocus-2081	63	20	genome	genome	NOUN
finefocus-2081	63	21	editing	editing	NOUN
finefocus-2081	63	22	was	be	AUX
finefocus-2081	63	23	broadly	broadly	ADV
finefocus-2081	63	24	applicable	applicable	ADJ
finefocus-2081	63	25	has	have	AUX
finefocus-2081	63	26	since	since	SCONJ
finefocus-2081	63	27	lead	lead	VERB
finefocus-2081	63	28	to	to	ADP
finefocus-2081	63	29	the	the	DET
finefocus-2081	63	30	development	development	NOUN
finefocus-2081	63	31	of	of	ADP
finefocus-2081	63	32	crispr	crispr	ADJ
finefocus-2081	63	33	systems	system	NOUN
finefocus-2081	63	34	in	in	ADP
finefocus-2081	63	35	numerous	numerous	ADJ
finefocus-2081	63	36	organisms	organism	NOUN
finefocus-2081	63	37	.	.	PUNCT
finefocus-2081	64	1	for	for	ADP
finefocus-2081	64	2	instance	instance	NOUN
finefocus-2081	64	3	,	,	PUNCT
finefocus-2081	64	4	in	in	ADP
finefocus-2081	64	5	the	the	DET
finefocus-2081	64	6	fungal	fungal	ADJ
finefocus-2081	64	7	kingdom	kingdom	NOUN
finefocus-2081	64	8	,	,	PUNCT
finefocus-2081	64	9	crispr	crispr	NOUN
finefocus-2081	64	10	-	-	PUNCT
finefocus-2081	64	11	mediated	mediate	VERB
finefocus-2081	64	12	genome	genome	NOUN
finefocus-2081	64	13	editing	editing	NOUN
finefocus-2081	64	14	systems	system	NOUN
finefocus-2081	64	15	have	have	AUX
finefocus-2081	64	16	been	be	AUX
finefocus-2081	64	17	established	establish	VERB
finefocus-2081	64	18	for	for	ADP
finefocus-2081	64	19	traditional	traditional	ADJ
finefocus-2081	64	20	yeast	yeast	NOUN
finefocus-2081	64	21	model	model	NOUN
finefocus-2081	64	22	systems	system	NOUN
finefocus-2081	64	23	such	such	ADJ
finefocus-2081	64	24	as	as	ADP
finefocus-2081	64	25	schizosaccharomyces	schizosaccharomyce	NOUN
finefocus-2081	64	26	pombe	pombe	NOUN
finefocus-2081	64	27	(	(	PUNCT
finefocus-2081	64	28	18	18	NUM
finefocus-2081	64	29	)	)	PUNCT
finefocus-2081	64	30	and	and	CCONJ
finefocus-2081	64	31	saccharomyces	saccharomyce	NOUN
finefocus-2081	64	32	cerevisiae	cerevisiae	NOUN
finefocus-2081	64	33	(	(	PUNCT
finefocus-2081	64	34	19	19	NUM
finefocus-2081	64	35	)	)	PUNCT
finefocus-2081	64	36	,	,	PUNCT
finefocus-2081	64	37	as	as	ADV
finefocus-2081	64	38	well	well	ADV
finefocus-2081	64	39	as	as	ADP
finefocus-2081	64	40	non	non	ADJ
finefocus-2081	64	41	-	-	ADJ
finefocus-2081	64	42	conventional	conventional	ADJ
finefocus-2081	64	43	yeast	yeast	NOUN
finefocus-2081	64	44	candida	candida	NOUN
finefocus-2081	64	45	glabrata	glabrata	NOUN
finefocus-2081	64	46	(	(	PUNCT
finefocus-2081	64	47	20	20	NUM
finefocus-2081	64	48	)	)	PUNCT
finefocus-2081	64	49	,	,	PUNCT
finefocus-2081	64	50	candida	candida	NOUN
finefocus-2081	64	51	albicans	albican	NOUN
finefocus-2081	64	52	(	(	PUNCT
finefocus-2081	64	53	21	21	NUM
finefocus-2081	64	54	)	)	PUNCT
finefocus-2081	64	55	,	,	PUNCT
finefocus-2081	64	56	yarrowia	yarrowia	PROPN
finefocus-2081	64	57	lipolytica	lipolytica	PROPN
finefocus-2081	64	58	(	(	PUNCT
finefocus-2081	64	59	22	22	NUM
finefocus-2081	64	60	)	)	PUNCT
finefocus-2081	64	61	,	,	PUNCT
finefocus-2081	64	62	kluyveromyces	kluyveromyce	VERB
finefocus-2081	64	63	lactis	lactis	PROPN
finefocus-2081	64	64	(	(	PUNCT
finefocus-2081	64	65	23	23	NUM
finefocus-2081	64	66	)	)	PUNCT
finefocus-2081	64	67	,	,	PUNCT
finefocus-2081	64	68	pichia	pichia	NOUN
finefocus-2081	64	69	pastoris	pastoris	NOUN
finefocus-2081	64	70	(	(	PUNCT
finefocus-2081	64	71	24	24	NUM
finefocus-2081	64	72	)	)	PUNCT
finefocus-2081	64	73	,	,	PUNCT
finefocus-2081	64	74	naumovozyma	naumovozyma	NOUN
finefocus-2081	64	75	castellii	castellii	NOUN
finefocus-2081	64	76	(	(	PUNCT
finefocus-2081	64	77	25	25	NUM
finefocus-2081	64	78	)	)	PUNCT
finefocus-2081	64	79	,	,	PUNCT
finefocus-2081	64	80	ogataea	ogataea	VERB
finefocus-2081	64	81	thermomethanolica	thermomethanolica	NOUN
finefocus-2081	64	82	(	(	PUNCT
finefocus-2081	64	83	26	26	NUM
finefocus-2081	64	84	)	)	PUNCT
finefocus-2081	64	85	,	,	PUNCT
finefocus-2081	64	86	candida	candida	PROPN
finefocus-2081	64	87	lusitaniae	lusitaniae	NOUN
finefocus-2081	64	88	(	(	PUNCT
finefocus-2081	64	89	27	27	NUM
finefocus-2081	64	90	)	)	PUNCT
finefocus-2081	64	91	,	,	PUNCT
finefocus-2081	64	92	candida	candida	PROPN
finefocus-2081	64	93	parapsilosis	parapsilosis	NOUN
finefocus-2081	64	94	(	(	PUNCT
finefocus-2081	64	95	28	28	NUM
finefocus-2081	64	96	)	)	PUNCT
finefocus-2081	64	97	,	,	PUNCT
finefocus-2081	64	98	cordyceps	cordycep	NOUN
finefocus-2081	64	99	militaris	militaris	NOUN
finefocus-2081	64	100	(	(	PUNCT
finefocus-2081	64	101	29	29	NUM
finefocus-2081	64	102	)	)	PUNCT
finefocus-2081	64	103	,	,	PUNCT
finefocus-2081	64	104	cryptococcus	cryptococcus	PROPN
finefocus-2081	64	105	neoformans	neoformans	PROPN
finefocus-2081	64	106	(	(	PUNCT
finefocus-2081	64	107	30	30	NUM
finefocus-2081	64	108	)	)	PUNCT
finefocus-2081	64	109	,	,	PUNCT
finefocus-2081	64	110	shefferomyces	shefferomyce	NOUN
finefocus-2081	64	111	stipites	stipes	NOUN
finefocus-2081	64	112	(	(	PUNCT
finefocus-2081	64	113	31	31	NUM
finefocus-2081	64	114	)	)	PUNCT
finefocus-2081	64	115	,	,	PUNCT
finefocus-2081	64	116	and	and	CCONJ
finefocus-2081	64	117	aspergillus	aspergillus	ADJ
finefocus-2081	64	118	fumigatus	fumigatus	NOUN
finefocus-2081	64	119	(	(	PUNCT
finefocus-2081	64	120	32	32	NUM
finefocus-2081	64	121	)	)	PUNCT
finefocus-2081	64	122	as	as	ADV
finefocus-2081	64	123	well	well	ADV
finefocus-2081	64	124	as	as	ADP
finefocus-2081	64	125	others	other	NOUN
finefocus-2081	64	126	.	.	PUNCT
finefocus-2081	65	1	in	in	ADP
finefocus-2081	65	2	addition	addition	NOUN
finefocus-2081	65	3	,	,	PUNCT
finefocus-2081	65	4	crisprmediated	crisprmediate	VERB
finefocus-2081	65	5	editing	editing	NOUN
finefocus-2081	65	6	systems	system	NOUN
finefocus-2081	65	7	have	have	AUX
finefocus-2081	65	8	been	be	AUX
finefocus-2081	65	9	developed	develop	VERB
finefocus-2081	65	10	for	for	ADP
finefocus-2081	65	11	many	many	ADJ
finefocus-2081	65	12	mammalian	mammalian	NOUN
finefocus-2081	65	13	(	(	PUNCT
finefocus-2081	65	14	33	33	NUM
finefocus-2081	65	15	)	)	PUNCT
finefocus-2081	65	16	and	and	CCONJ
finefocus-2081	65	17	plant	plant	NOUN
finefocus-2081	65	18	model	model	NOUN
finefocus-2081	65	19	systems	system	NOUN
finefocus-2081	65	20	(	(	PUNCT
finefocus-2081	65	21	34	34	NUM
finefocus-2081	65	22	)	)	PUNCT
finefocus-2081	65	23	,	,	PUNCT
finefocus-2081	65	24	as	as	ADV
finefocus-2081	65	25	well	well	ADV
finefocus-2081	65	26	as	as	ADP
finefocus-2081	65	27	other	other	ADJ
finefocus-2081	65	28	organisms	organism	NOUN
finefocus-2081	65	29	whose	whose	DET
finefocus-2081	65	30	genomes	genome	NOUN
finefocus-2081	65	31	have	have	AUX
finefocus-2081	65	32	historically	historically	ADV
finefocus-2081	65	33	been	be	AUX
finefocus-2081	65	34	challenging	challenge	VERB
finefocus-2081	65	35	to	to	PART
finefocus-2081	65	36	manipulate	manipulate	VERB
finefocus-2081	65	37	(	(	PUNCT
finefocus-2081	65	38	21	21	NUM
finefocus-2081	65	39	,	,	PUNCT
finefocus-2081	65	40	35	35	NUM
finefocus-2081	65	41	)	)	PUNCT
finefocus-2081	65	42	.	.	PUNCT
finefocus-2081	66	1	this	this	DET
finefocus-2081	66	2	expansion	expansion	NOUN
finefocus-2081	66	3	of	of	ADP
finefocus-2081	66	4	the	the	DET
finefocus-2081	66	5	use	use	NOUN
finefocus-2081	66	6	of	of	ADP
finefocus-2081	66	7	crispr	crispr	NOUN
finefocus-2081	66	8	is	be	AUX
finefocus-2081	66	9	similarly	similarly	ADV
finefocus-2081	66	10	demonstrated	demonstrate	VERB
finefocus-2081	66	11	by	by	ADP
finefocus-2081	66	12	online	online	ADJ
finefocus-2081	66	13	mentions	mention	NOUN
finefocus-2081	66	14	.	.	PUNCT
finefocus-2081	67	1	in	in	ADP
finefocus-2081	67	2	2004	2004	NUM
finefocus-2081	67	3	a	a	DET
finefocus-2081	67	4	keyword	keyword	NOUN
finefocus-2081	67	5	search	search	NOUN
finefocus-2081	67	6	for	for	ADP
finefocus-2081	67	7	crispr	crispr	NOUN
finefocus-2081	67	8	of	of	ADP
finefocus-2081	67	9	the	the	DET
finefocus-2081	67	10	pubmed	pubmed	PROPN
finefocus-2081	67	11	database	database	NOUN
finefocus-2081	67	12	would	would	AUX
finefocus-2081	67	13	have	have	AUX
finefocus-2081	67	14	retrieved	retrieve	VERB
finefocus-2081	67	15	under	under	ADP
finefocus-2081	67	16	ten	ten	NUM
finefocus-2081	67	17	papers	paper	NOUN
finefocus-2081	67	18	.	.	PUNCT
finefocus-2081	68	1	in	in	ADP
finefocus-2081	68	2	2017	2017	NUM
finefocus-2081	68	3	alone	alone	ADV
finefocus-2081	68	4	,	,	PUNCT
finefocus-2081	68	5	over	over	ADP
finefocus-2081	68	6	3000	3000	NUM
finefocus-2081	68	7	papers	paper	NOUN
finefocus-2081	68	8	with	with	ADP
finefocus-2081	68	9	the	the	DET
finefocus-2081	68	10	key	key	ADJ
finefocus-2081	68	11	word	word	NOUN
finefocus-2081	68	12	crispr	crispr	NOUN
finefocus-2081	68	13	were	be	AUX
finefocus-2081	68	14	deposited	deposit	VERB
finefocus-2081	68	15	and	and	CCONJ
finefocus-2081	68	16	indexed	index	VERB
finefocus-2081	68	17	on	on	ADP
finefocus-2081	68	18	pubmed	pubmed	PROPN
finefocus-2081	68	19	(	(	PUNCT
finefocus-2081	68	20	figure	figure	NOUN
finefocus-2081	68	21	3	3	NUM
finefocus-2081	68	22	)	)	PUNCT
finefocus-2081	68	23	.	.	PUNCT
finefocus-2081	69	1	google	google	PROPN
finefocus-2081	69	2	searches	search	NOUN
finefocus-2081	69	3	for	for	ADP
finefocus-2081	69	4	crispr	crispr	NOUN
finefocus-2081	69	5	have	have	AUX
finefocus-2081	69	6	had	have	VERB
finefocus-2081	69	7	a	a	DET
finefocus-2081	69	8	similar	similar	ADJ
finefocus-2081	69	9	meteoric	meteoric	ADJ
finefocus-2081	69	10	rise	rise	NOUN
finefocus-2081	69	11	in	in	ADP
finefocus-2081	69	12	popularity	popularity	NOUN
finefocus-2081	69	13	over	over	ADP
finefocus-2081	69	14	the	the	DET
finefocus-2081	69	15	same	same	ADJ
finefocus-2081	69	16	time	time	NOUN
finefocus-2081	69	17	period	period	NOUN
finefocus-2081	69	18	(	(	PUNCT
finefocus-2081	69	19	figure	figure	NOUN
finefocus-2081	69	20	3	3	NUM
finefocus-2081	69	21	)	)	PUNCT
finefocus-2081	69	22	and	and	CCONJ
finefocus-2081	69	23	this	this	DET
finefocus-2081	69	24	rise	rise	NOUN
finefocus-2081	69	25	in	in	ADP
finefocus-2081	69	26	popularity	popularity	NOUN
finefocus-2081	69	27	has	have	AUX
finefocus-2081	69	28	led	lead	VERB
finefocus-2081	69	29	to	to	ADP
finefocus-2081	69	30	articles	article	NOUN
finefocus-2081	69	31	and	and	CCONJ
finefocus-2081	69	32	features	feature	NOUN
finefocus-2081	69	33	in	in	ADP
finefocus-2081	69	34	popular	popular	ADJ
finefocus-2081	69	35	media	medium	NOUN
finefocus-2081	69	36	(	(	PUNCT
finefocus-2081	69	37	36	36	NUM
finefocus-2081	69	38	,	,	PUNCT
finefocus-2081	69	39	37	37	NUM
finefocus-2081	69	40	)	)	PUNCT
finefocus-2081	69	41	.	.	PUNCT
finefocus-2081	70	1	crispr	crispr	PROPN
finefocus-2081	70	2	’s	’s	PART
finefocus-2081	70	3	appeal	appeal	NOUN
finefocus-2081	70	4	is	be	AUX
finefocus-2081	70	5	in	in	ADP
finefocus-2081	70	6	part	part	NOUN
finefocus-2081	70	7	due	due	ADP
finefocus-2081	70	8	to	to	ADP
finefocus-2081	70	9	the	the	DET
finefocus-2081	70	10	relative	relative	ADJ
finefocus-2081	70	11	ease	ease	NOUN
finefocus-2081	70	12	by	by	ADP
finefocus-2081	70	13	which	which	PRON
finefocus-2081	70	14	it	it	PRON
finefocus-2081	70	15	can	can	AUX
finefocus-2081	70	16	be	be	AUX
finefocus-2081	70	17	applied	apply	VERB
finefocus-2081	70	18	to	to	ADP
finefocus-2081	70	19	a	a	DET
finefocus-2081	70	20	wide	wide	ADJ
finefocus-2081	70	21	variety	variety	NOUN
finefocus-2081	70	22	of	of	ADP
finefocus-2081	70	23	biological	biological	ADJ
finefocus-2081	70	24	systems	system	NOUN
finefocus-2081	70	25	.	.	PUNCT
finefocus-2081	71	1	such	such	ADJ
finefocus-2081	71	2	promiscuity	promiscuity	NOUN
finefocus-2081	71	3	gives	give	VERB
finefocus-2081	71	4	crisprmediated	crisprmediate	VERB
finefocus-2081	71	5	genome	genome	NOUN
finefocus-2081	71	6	editing	edit	VERB
finefocus-2081	71	7	the	the	DET
finefocus-2081	71	8	potential	potential	NOUN
finefocus-2081	71	9	to	to	PART
finefocus-2081	71	10	effect	effect	VERB
finefocus-2081	71	11	human	human	ADJ
finefocus-2081	71	12	well	well	ADV
finefocus-2081	71	13	-	-	PUNCT
finefocus-2081	71	14	being	being	NOUN
finefocus-2081	71	15	in	in	ADP
finefocus-2081	71	16	a	a	DET
finefocus-2081	71	17	multitude	multitude	NOUN
finefocus-2081	71	18	of	of	ADP
finefocus-2081	71	19	ways	way	NOUN
finefocus-2081	71	20	(	(	PUNCT
finefocus-2081	71	21	38	38	NUM
finefocus-2081	71	22	)	)	PUNCT
finefocus-2081	71	23	.	.	PUNCT
finefocus-2081	72	1	genome	genome	NOUN
finefocus-2081	72	2	engineering	engineering	NOUN
finefocus-2081	72	3	in	in	ADP
finefocus-2081	72	4	agriculture	agriculture	NOUN
finefocus-2081	72	5	has	have	VERB
finefocus-2081	72	6	the	the	DET
finefocus-2081	72	7	potential	potential	NOUN
finefocus-2081	72	8	to	to	PART
finefocus-2081	72	9	increase	increase	VERB
finefocus-2081	72	10	yields	yield	NOUN
finefocus-2081	72	11	and	and	CCONJ
finefocus-2081	72	12	develop	develop	VERB
finefocus-2081	72	13	more	more	ADJ
finefocus-2081	72	14	nutritional	nutritional	ADJ
finefocus-2081	72	15	food	food	NOUN
finefocus-2081	72	16	products	product	NOUN
finefocus-2081	72	17	(	(	PUNCT
finefocus-2081	72	18	39	39	NUM
finefocus-2081	72	19	)	)	PUNCT
finefocus-2081	72	20	.	.	PUNCT
finefocus-2081	73	1	gene	gene	NOUN
finefocus-2081	73	2	drive	drive	PROPN
finefocus-2081	73	3	technologies	technology	NOUN
finefocus-2081	73	4	that	that	PRON
finefocus-2081	73	5	use	use	VERB
finefocus-2081	73	6	crispr	crispr	ADJ
finefocus-2081	73	7	cas9	cas9	NOUN
finefocus-2081	73	8	to	to	PART
finefocus-2081	73	9	spread	spread	VERB
finefocus-2081	73	10	genes	gene	NOUN
finefocus-2081	73	11	in	in	ADP
finefocus-2081	73	12	wild	wild	ADJ
finefocus-2081	73	13	arthropod	arthropod	ADJ
finefocus-2081	73	14	populations	population	NOUN
finefocus-2081	73	15	could	could	AUX
finefocus-2081	73	16	fundamentally	fundamentally	ADV
finefocus-2081	73	17	alter	alter	VERB
finefocus-2081	73	18	crop	crop	NOUN
finefocus-2081	73	19	management	management	NOUN
finefocus-2081	73	20	strategies	strategy	NOUN
finefocus-2081	73	21	and	and	CCONJ
finefocus-2081	73	22	reduce	reduce	VERB
finefocus-2081	73	23	pesticide	pesticide	NOUN
finefocus-2081	73	24	use	use	NOUN
finefocus-2081	73	25	(	(	PUNCT
finefocus-2081	73	26	40	40	NUM
finefocus-2081	73	27	)	)	PUNCT
finefocus-2081	73	28	.	.	PUNCT
finefocus-2081	74	1	similar	similar	ADJ
finefocus-2081	74	2	gene	gene	NOUN
finefocus-2081	74	3	drive	drive	NOUN
finefocus-2081	74	4	strategies	strategy	NOUN
finefocus-2081	74	5	could	could	AUX
finefocus-2081	74	6	be	be	AUX
finefocus-2081	74	7	employed	employ	VERB
finefocus-2081	74	8	to	to	PART
finefocus-2081	74	9	limit	limit	VERB
finefocus-2081	74	10	the	the	DET
finefocus-2081	74	11	spread	spread	NOUN
finefocus-2081	74	12	of	of	ADP
finefocus-2081	74	13	diseases	disease	NOUN
finefocus-2081	74	14	such	such	ADJ
finefocus-2081	74	15	as	as	ADP
finefocus-2081	74	16	malaria	malaria	NOUN
finefocus-2081	74	17	(	(	PUNCT
finefocus-2081	74	18	41	41	NUM
finefocus-2081	74	19	)	)	PUNCT
finefocus-2081	74	20	.	.	PUNCT
finefocus-2081	75	1	however	however	ADV
finefocus-2081	75	2	the	the	DET
finefocus-2081	75	3	release	release	NOUN
finefocus-2081	75	4	of	of	ADP
finefocus-2081	75	5	genetically	genetically	ADV
finefocus-2081	75	6	modified	modify	VERB
finefocus-2081	75	7	organisms	organism	NOUN
finefocus-2081	75	8	to	to	ADP
finefocus-2081	75	9	the	the	DET
finefocus-2081	75	10	wild	wild	NOUN
finefocus-2081	75	11	is	be	AUX
finefocus-2081	75	12	controversial	controversial	ADJ
finefocus-2081	75	13	and	and	CCONJ
finefocus-2081	75	14	crispr	crispr	ADJ
finefocus-2081	75	15	•	•	NUM
finefocus-2081	75	16	27	27	NUM
finefocus-2081	75	17	figure	figure	NOUN
finefocus-2081	75	18	3	3	NUM
finefocus-2081	75	19	.	.	PUNCT
finefocus-2081	76	1	the	the	DET
finefocus-2081	76	2	increase	increase	NOUN
finefocus-2081	76	3	in	in	ADP
finefocus-2081	76	4	crispr	crispr	ADJ
finefocus-2081	76	5	related	relate	VERB
finefocus-2081	76	6	academic	academic	ADJ
finefocus-2081	76	7	and	and	CCONJ
finefocus-2081	76	8	social	social	ADJ
finefocus-2081	76	9	materials	material	NOUN
finefocus-2081	76	10	over	over	ADP
finefocus-2081	76	11	time	time	NOUN
finefocus-2081	76	12	.	.	PUNCT
finefocus-2081	77	1	a.	a.	PROPN
finefocus-2081	77	2	crispr	crispr	PROPN
finefocus-2081	77	3	publications	publication	NOUN
finefocus-2081	77	4	indexed	index	VERB
finefocus-2081	77	5	on	on	ADP
finefocus-2081	77	6	pubmed	pubmed	PROPN
finefocus-2081	77	7	.	.	PUNCT
finefocus-2081	78	1	number	number	NOUN
finefocus-2081	78	2	of	of	ADP
finefocus-2081	78	3	publications	publication	NOUN
finefocus-2081	78	4	submitted	submit	VERB
finefocus-2081	78	5	to	to	ADP
finefocus-2081	78	6	pubmed	pubmed	PROPN
finefocus-2081	78	7	indexed	index	VERB
finefocus-2081	78	8	with	with	ADP
finefocus-2081	78	9	the	the	DET
finefocus-2081	78	10	key	key	ADJ
finefocus-2081	78	11	word	word	NOUN
finefocus-2081	78	12	crispr	crispr	ADJ
finefocus-2081	78	13	by	by	ADP
finefocus-2081	78	14	year	year	NOUN
finefocus-2081	78	15	.	.	PUNCT
finefocus-2081	79	1	b.	b.	PROPN
finefocus-2081	79	2	crispr	crispr	PROPN
finefocus-2081	79	3	google	google	PROPN
finefocus-2081	79	4	search	search	NOUN
finefocus-2081	79	5	trends	trend	NOUN
finefocus-2081	79	6	.	.	PUNCT
finefocus-2081	80	1	google	google	PROPN
finefocus-2081	80	2	search	search	NOUN
finefocus-2081	80	3	frequency	frequency	NOUN
finefocus-2081	80	4	from	from	ADP
finefocus-2081	80	5	2004	2004	NUM
finefocus-2081	80	6	to	to	ADP
finefocus-2081	80	7	2017	2017	NUM
finefocus-2081	80	8	.	.	PUNCT
finefocus-2081	81	1	each	each	DET
finefocus-2081	81	2	data	datum	NOUN
finefocus-2081	81	3	point	point	NOUN
finefocus-2081	81	4	is	be	AUX
finefocus-2081	81	5	divided	divide	VERB
finefocus-2081	81	6	by	by	ADP
finefocus-2081	81	7	the	the	DET
finefocus-2081	81	8	total	total	ADJ
finefocus-2081	81	9	searches	search	NOUN
finefocus-2081	81	10	of	of	ADP
finefocus-2081	81	11	the	the	DET
finefocus-2081	81	12	geography	geography	NOUN
finefocus-2081	81	13	and	and	CCONJ
finefocus-2081	81	14	time	time	NOUN
finefocus-2081	81	15	range	range	NOUN
finefocus-2081	81	16	it	it	PRON
finefocus-2081	81	17	represents	represent	VERB
finefocus-2081	81	18	to	to	PART
finefocus-2081	81	19	compare	compare	VERB
finefocus-2081	81	20	relative	relative	ADJ
finefocus-2081	81	21	popularity	popularity	NOUN
finefocus-2081	81	22	.	.	PUNCT
finefocus-2081	82	1	time	time	NOUN
finefocus-2081	82	2	period	period	NOUN
finefocus-2081	82	3	with	with	ADP
finefocus-2081	82	4	the	the	DET
finefocus-2081	82	5	highest	high	ADJ
finefocus-2081	82	6	search	search	NOUN
finefocus-2081	82	7	frequency	frequency	NOUN
finefocus-2081	82	8	will	will	AUX
finefocus-2081	82	9	score	score	VERB
finefocus-2081	82	10	100	100	NUM
finefocus-2081	82	11	,	,	PUNCT
finefocus-2081	82	12	while	while	SCONJ
finefocus-2081	82	13	the	the	DET
finefocus-2081	82	14	time	time	NOUN
finefocus-2081	82	15	period	period	NOUN
finefocus-2081	82	16	with	with	ADP
finefocus-2081	82	17	the	the	DET
finefocus-2081	82	18	lowest	low	ADJ
finefocus-2081	82	19	frequency	frequency	NOUN
finefocus-2081	82	20	of	of	ADP
finefocus-2081	82	21	searches	search	NOUN
finefocus-2081	82	22	will	will	AUX
finefocus-2081	82	23	score	score	VERB
finefocus-2081	82	24	1	1	NUM
finefocus-2081	82	25	.	.	PUNCT
finefocus-2081	82	26	figure	figure	NOUN
finefocus-2081	82	27	4	4	NUM
finefocus-2081	82	28	.	.	NOUN
finefocus-2081	82	29	crispr	crispr	ADJ
finefocus-2081	82	30	mediated	mediate	VERB
finefocus-2081	82	31	genome	genome	NOUN
finefocus-2081	82	32	editing	editing	NOUN
finefocus-2081	82	33	of	of	ADP
finefocus-2081	82	34	s.	s.	PROPN
finefocus-2081	82	35	cerevisiae	cerevisiae	PROPN
finefocus-2081	82	36	ade2	ade2	PROPN
finefocus-2081	82	37	.	.	PUNCT
finefocus-2081	83	1	repair	repair	NOUN
finefocus-2081	83	2	of	of	ADP
finefocus-2081	83	3	the	the	DET
finefocus-2081	83	4	cleavage	cleavage	NOUN
finefocus-2081	83	5	sites	site	NOUN
finefocus-2081	83	6	in	in	ADP
finefocus-2081	83	7	the	the	DET
finefocus-2081	83	8	two	two	NUM
finefocus-2081	83	9	strains	strain	NOUN
finefocus-2081	83	10	of	of	ADP
finefocus-2081	83	11	yeast	yeast	NOUN
finefocus-2081	83	12	were	be	AUX
finefocus-2081	83	13	shown	show	VERB
finefocus-2081	83	14	was	be	AUX
finefocus-2081	83	15	done	do	VERB
finefocus-2081	83	16	by	by	ADP
finefocus-2081	83	17	homologous	homologous	ADJ
finefocus-2081	83	18	recombination	recombination	NOUN
finefocus-2081	83	19	.	.	PUNCT
finefocus-2081	84	1	stop	stop	VERB
finefocus-2081	84	2	codons	codon	NOUN
finefocus-2081	84	3	were	be	AUX
finefocus-2081	84	4	inserted	insert	VERB
finefocus-2081	84	5	into	into	ADP
finefocus-2081	84	6	the	the	DET
finefocus-2081	84	7	5	5	NUM
finefocus-2081	84	8	’	'	PUNCT
finefocus-2081	84	9	end	end	NOUN
finefocus-2081	84	10	of	of	ADP
finefocus-2081	84	11	the	the	DET
finefocus-2081	84	12	ade2	ade2	PROPN
finefocus-2081	84	13	gene	gene	NOUN
finefocus-2081	84	14	generating	generate	VERB
finefocus-2081	84	15	a	a	DET
finefocus-2081	84	16	functional	functional	ADJ
finefocus-2081	84	17	deletion	deletion	NOUN
finefocus-2081	84	18	.	.	PUNCT
finefocus-2081	85	1	pink	pink	ADJ
finefocus-2081	85	2	and	and	CCONJ
finefocus-2081	85	3	red	red	ADJ
finefocus-2081	85	4	colonies	colony	NOUN
finefocus-2081	85	5	indicate	indicate	VERB
finefocus-2081	85	6	successful	successful	ADJ
finefocus-2081	85	7	genome	genome	NOUN
finefocus-2081	85	8	editing	editing	NOUN
finefocus-2081	85	9	while	while	SCONJ
finefocus-2081	85	10	white	white	ADJ
finefocus-2081	85	11	colonies	colony	NOUN
finefocus-2081	85	12	are	be	AUX
finefocus-2081	85	13	unedited	unedited	ADJ
finefocus-2081	85	14	s.	s.	PROPN
finefocus-2081	85	15	cerevisiae	cerevisiae	PROPN
finefocus-2081	85	16	.	.	PUNCT
finefocus-2081	86	1	a.	a.	NOUN
finefocus-2081	86	2	commercially	commercially	ADV
finefocus-2081	86	3	available	available	ADJ
finefocus-2081	86	4	baking	baking	NOUN
finefocus-2081	86	5	strain	strain	NOUN
finefocus-2081	86	6	,	,	PUNCT
finefocus-2081	86	7	red	red	ADJ
finefocus-2081	86	8	star	star	NOUN
finefocus-2081	86	9	quick	quick	ADJ
finefocus-2081	86	10	rise	rise	VERB
finefocus-2081	86	11	instant	instant	ADJ
finefocus-2081	86	12	yeast	yeast	NOUN
finefocus-2081	86	13	.	.	PUNCT
finefocus-2081	87	1	b.	b.	PROPN
finefocus-2081	87	2	commercially	commercially	ADV
finefocus-2081	87	3	available	available	ADJ
finefocus-2081	87	4	brewing	brewing	NOUN
finefocus-2081	87	5	strain	strain	NOUN
finefocus-2081	87	6	,	,	PUNCT
finefocus-2081	87	7	lallemand	lallemand	NOUN
finefocus-2081	87	8	nottingham	nottingham	PROPN
finefocus-2081	87	9	ale	ale	NOUN
finefocus-2081	87	10	brewing	brewing	NOUN
finefocus-2081	87	11	yeast	yeast	NOUN
finefocus-2081	87	12	.	.	PUNCT
finefocus-2081	88	1	28	28	NUM
finefocus-2081	88	2	•	•	NUM
finefocus-2081	88	3	fine	fine	ADJ
finefocus-2081	88	4	focus	focus	NOUN
finefocus-2081	88	5	,	,	PUNCT
finefocus-2081	88	6	vol	vol	NOUN
finefocus-2081	88	7	5	5	NUM
finefocus-2081	88	8	2019	2019	NUM
finefocus-2081	88	9	one	one	NUM
finefocus-2081	88	10	way	way	NOUN
finefocus-2081	88	11	students	student	NOUN
finefocus-2081	88	12	can	can	AUX
finefocus-2081	88	13	be	be	AUX
finefocus-2081	88	14	exposed	expose	VERB
finefocus-2081	88	15	to	to	ADP
finefocus-2081	88	16	crispr	crispr	NOUN
finefocus-2081	88	17	-	-	PUNCT
finefocus-2081	88	18	mediated	mediate	VERB
finefocus-2081	88	19	genome	genome	NOUN
finefocus-2081	88	20	editing	editing	NOUN
finefocus-2081	88	21	is	be	AUX
finefocus-2081	88	22	by	by	ADP
finefocus-2081	88	23	applying	apply	VERB
finefocus-2081	88	24	it	it	PRON
finefocus-2081	88	25	to	to	ADP
finefocus-2081	88	26	an	an	DET
finefocus-2081	88	27	undergraduate	undergraduate	ADJ
finefocus-2081	88	28	research	research	NOUN
finefocus-2081	88	29	project	project	NOUN
finefocus-2081	88	30	.	.	PUNCT
finefocus-2081	89	1	welldesigned	welldesigne	VERB
finefocus-2081	89	2	undergraduate	undergraduate	NOUN
finefocus-2081	89	3	research	research	NOUN
finefocus-2081	89	4	projects	project	NOUN
finefocus-2081	89	5	both	both	PRON
finefocus-2081	89	6	train	train	NOUN
finefocus-2081	89	7	students	student	NOUN
finefocus-2081	89	8	and	and	CCONJ
finefocus-2081	89	9	move	move	VERB
finefocus-2081	89	10	a	a	DET
finefocus-2081	89	11	larger	large	ADJ
finefocus-2081	89	12	research	research	NOUN
finefocus-2081	89	13	program	program	NOUN
finefocus-2081	89	14	forward	forward	ADV
finefocus-2081	89	15	.	.	PUNCT
finefocus-2081	90	1	undergraduates	undergraduate	NOUN
finefocus-2081	90	2	typically	typically	ADV
finefocus-2081	90	3	have	have	VERB
finefocus-2081	90	4	limited	limit	VERB
finefocus-2081	90	5	time	time	NOUN
finefocus-2081	90	6	they	they	PRON
finefocus-2081	90	7	can	can	AUX
finefocus-2081	90	8	devote	devote	VERB
finefocus-2081	90	9	to	to	ADP
finefocus-2081	90	10	a	a	DET
finefocus-2081	90	11	research	research	NOUN
finefocus-2081	90	12	project	project	NOUN
finefocus-2081	90	13	and	and	CCONJ
finefocus-2081	90	14	their	their	PRON
finefocus-2081	90	15	tenure	tenure	NOUN
finefocus-2081	90	16	in	in	ADP
finefocus-2081	90	17	a	a	DET
finefocus-2081	90	18	lab	lab	NOUN
finefocus-2081	90	19	is	be	AUX
finefocus-2081	90	20	likely	likely	ADJ
finefocus-2081	90	21	to	to	PART
finefocus-2081	90	22	be	be	AUX
finefocus-2081	90	23	shorter	short	ADJ
finefocus-2081	90	24	than	than	ADP
finefocus-2081	90	25	that	that	PRON
finefocus-2081	90	26	of	of	ADP
finefocus-2081	90	27	a	a	DET
finefocus-2081	90	28	graduate	graduate	NOUN
finefocus-2081	90	29	student	student	NOUN
finefocus-2081	90	30	or	or	CCONJ
finefocus-2081	90	31	more	more	ADJ
finefocus-2081	90	32	senior	senior	ADJ
finefocus-2081	90	33	scientist	scientist	NOUN
finefocus-2081	90	34	.	.	PUNCT
finefocus-2081	91	1	such	such	ADJ
finefocus-2081	91	2	limitations	limitation	NOUN
finefocus-2081	91	3	make	make	VERB
finefocus-2081	91	4	it	it	PRON
finefocus-2081	91	5	crucial	crucial	ADJ
finefocus-2081	91	6	that	that	SCONJ
finefocus-2081	91	7	students	student	NOUN
finefocus-2081	91	8	generate	generate	VERB
finefocus-2081	91	9	strains	strain	NOUN
finefocus-2081	91	10	and	and	CCONJ
finefocus-2081	91	11	reagents	reagent	NOUN
finefocus-2081	91	12	required	require	VERB
finefocus-2081	91	13	to	to	PART
finefocus-2081	91	14	test	test	VERB
finefocus-2081	91	15	a	a	DET
finefocus-2081	91	16	hypothesis	hypothesis	NOUN
finefocus-2081	91	17	in	in	ADP
finefocus-2081	91	18	a	a	DET
finefocus-2081	91	19	timely	timely	ADJ
finefocus-2081	91	20	manner	manner	NOUN
finefocus-2081	91	21	.	.	PUNCT
finefocus-2081	92	1	in	in	ADP
finefocus-2081	92	2	some	some	DET
finefocus-2081	92	3	fields	field	NOUN
finefocus-2081	92	4	,	,	PUNCT
finefocus-2081	92	5	crispr	crispr	NOUN
finefocus-2081	92	6	-	-	PUNCT
finefocus-2081	92	7	mediated	mediate	VERB
finefocus-2081	92	8	genome	genome	NOUN
finefocus-2081	92	9	editing	editing	NOUN
finefocus-2081	92	10	has	have	AUX
finefocus-2081	92	11	increased	increase	VERB
finefocus-2081	92	12	the	the	DET
finefocus-2081	92	13	speed	speed	NOUN
finefocus-2081	92	14	by	by	ADP
finefocus-2081	92	15	which	which	PRON
finefocus-2081	92	16	investigators	investigator	NOUN
finefocus-2081	92	17	can	can	AUX
finefocus-2081	92	18	generate	generate	VERB
finefocus-2081	92	19	such	such	ADJ
finefocus-2081	92	20	materials	material	NOUN
finefocus-2081	92	21	.	.	PUNCT
finefocus-2081	93	1	for	for	ADP
finefocus-2081	93	2	instance	instance	NOUN
finefocus-2081	93	3	,	,	PUNCT
finefocus-2081	93	4	the	the	DET
finefocus-2081	93	5	human	human	ADJ
finefocus-2081	93	6	fungal	fungal	ADJ
finefocus-2081	93	7	pathogen	pathogen	NOUN
finefocus-2081	93	8	c.	c.	NOUN
finefocus-2081	93	9	albicans	albican	NOUN
finefocus-2081	93	10	is	be	AUX
finefocus-2081	93	11	diploid	diploid	ADJ
finefocus-2081	93	12	(	(	PUNCT
finefocus-2081	93	13	51	51	NUM
finefocus-2081	93	14	)	)	PUNCT
finefocus-2081	93	15	,	,	PUNCT
finefocus-2081	93	16	does	do	AUX
finefocus-2081	93	17	not	not	PART
finefocus-2081	93	18	undergo	undergo	VERB
finefocus-2081	93	19	meiosis	meiosis	NOUN
finefocus-2081	93	20	,	,	PUNCT
finefocus-2081	93	21	and	and	CCONJ
finefocus-2081	93	22	can	can	AUX
finefocus-2081	93	23	not	not	PART
finefocus-2081	93	24	maintain	maintain	VERB
finefocus-2081	93	25	plasmids	plasmid	NOUN
finefocus-2081	93	26	.	.	PUNCT
finefocus-2081	94	1	historically	historically	ADV
finefocus-2081	94	2	,	,	PUNCT
finefocus-2081	94	3	genetic	genetic	ADJ
finefocus-2081	94	4	manipulation	manipulation	NOUN
finefocus-2081	94	5	of	of	ADP
finefocus-2081	94	6	c.	c.	NOUN
finefocus-2081	94	7	albicans	albican	NOUN
finefocus-2081	94	8	required	require	VERB
finefocus-2081	94	9	multiple	multiple	ADJ
finefocus-2081	94	10	rounds	round	NOUN
finefocus-2081	94	11	of	of	ADP
finefocus-2081	94	12	homologous	homologous	ADJ
finefocus-2081	94	13	recombination	recombination	NOUN
finefocus-2081	94	14	as	as	SCONJ
finefocus-2081	94	15	each	each	DET
finefocus-2081	94	16	allele	allele	NOUN
finefocus-2081	94	17	must	must	AUX
finefocus-2081	94	18	be	be	AUX
finefocus-2081	94	19	mutated	mutate	VERB
finefocus-2081	94	20	independently	independently	ADV
finefocus-2081	94	21	and	and	CCONJ
finefocus-2081	94	22	screened	screen	VERB
finefocus-2081	94	23	in	in	ADP
finefocus-2081	94	24	succession	succession	NOUN
finefocus-2081	94	25	(	(	PUNCT
finefocus-2081	94	26	52	52	NUM
finefocus-2081	94	27	)	)	PUNCT
finefocus-2081	94	28	.	.	PUNCT
finefocus-2081	95	1	as	as	ADP
finefocus-2081	95	2	ploidy	ploidy	ADJ
finefocus-2081	95	3	increases	increase	NOUN
finefocus-2081	95	4	genetic	genetic	ADJ
finefocus-2081	95	5	manipulation	manipulation	NOUN
finefocus-2081	95	6	generally	generally	ADV
finefocus-2081	95	7	becomes	become	VERB
finefocus-2081	95	8	more	more	ADV
finefocus-2081	95	9	laborious	laborious	ADJ
finefocus-2081	95	10	.	.	PUNCT
finefocus-2081	96	1	these	these	DET
finefocus-2081	96	2	characteristics	characteristic	NOUN
finefocus-2081	96	3	made	make	VERB
finefocus-2081	96	4	it	it	PRON
finefocus-2081	96	5	considerably	considerably	ADV
finefocus-2081	96	6	more	more	ADV
finefocus-2081	96	7	challenging	challenging	ADJ
finefocus-2081	96	8	to	to	PART
finefocus-2081	96	9	work	work	VERB
finefocus-2081	96	10	with	with	ADP
finefocus-2081	96	11	than	than	ADP
finefocus-2081	96	12	other	other	ADJ
finefocus-2081	96	13	fungal	fungal	ADJ
finefocus-2081	96	14	model	model	NOUN
finefocus-2081	96	15	systems	system	NOUN
finefocus-2081	96	16	such	such	ADJ
finefocus-2081	96	17	s.	s.	PROPN
finefocus-2081	96	18	cerevisiae	cerevisiae	PROPN
finefocus-2081	96	19	.	.	PUNCT
finefocus-2081	97	1	the	the	DET
finefocus-2081	97	2	development	development	NOUN
finefocus-2081	97	3	of	of	ADP
finefocus-2081	97	4	crispr	crispr	NOUN
finefocus-2081	97	5	-	-	PUNCT
finefocus-2081	97	6	mediated	mediate	VERB
finefocus-2081	97	7	genome	genome	NOUN
finefocus-2081	97	8	editing	editing	NOUN
finefocus-2081	97	9	in	in	ADP
finefocus-2081	97	10	c.	c.	NOUN
finefocus-2081	97	11	albicans	albican	NOUN
finefocus-2081	97	12	has	have	AUX
finefocus-2081	97	13	greatly	greatly	ADV
finefocus-2081	97	14	increased	increase	VERB
finefocus-2081	97	15	the	the	DET
finefocus-2081	97	16	speed	speed	NOUN
finefocus-2081	97	17	at	at	ADP
finefocus-2081	97	18	which	which	PRON
finefocus-2081	97	19	genetic	genetic	ADJ
finefocus-2081	97	20	engineering	engineering	NOUN
finefocus-2081	97	21	can	can	AUX
finefocus-2081	97	22	be	be	AUX
finefocus-2081	97	23	performed	perform	VERB
finefocus-2081	97	24	and	and	CCONJ
finefocus-2081	97	25	allows	allow	VERB
finefocus-2081	97	26	undergraduate	undergraduate	ADJ
finefocus-2081	97	27	researchers	researcher	NOUN
finefocus-2081	97	28	to	to	PART
finefocus-2081	97	29	generate	generate	VERB
finefocus-2081	97	30	strains	strain	NOUN
finefocus-2081	97	31	quickly	quickly	ADV
finefocus-2081	97	32	(	(	PUNCT
finefocus-2081	97	33	25	25	NUM
finefocus-2081	97	34	,	,	PUNCT
finefocus-2081	97	35	53	53	NUM
finefocus-2081	97	36	)	)	PUNCT
finefocus-2081	97	37	.	.	PUNCT
finefocus-2081	98	1	such	such	ADJ
finefocus-2081	98	2	efficiency	efficiency	NOUN
finefocus-2081	98	3	is	be	AUX
finefocus-2081	98	4	important	important	ADJ
finefocus-2081	98	5	so	so	SCONJ
finefocus-2081	98	6	students	student	NOUN
finefocus-2081	98	7	make	make	VERB
finefocus-2081	98	8	progress	progress	NOUN
finefocus-2081	98	9	on	on	ADP
finefocus-2081	98	10	a	a	DET
finefocus-2081	98	11	project	project	NOUN
finefocus-2081	98	12	and	and	CCONJ
finefocus-2081	98	13	are	be	AUX
finefocus-2081	98	14	afforded	afford	VERB
finefocus-2081	98	15	the	the	DET
finefocus-2081	98	16	opportunity	opportunity	NOUN
finefocus-2081	98	17	to	to	PART
finefocus-2081	98	18	witness	witness	VERB
finefocus-2081	98	19	the	the	DET
finefocus-2081	98	20	payoff	payoff	NOUN
finefocus-2081	98	21	of	of	ADP
finefocus-2081	98	22	performing	perform	VERB
finefocus-2081	98	23	hypothesis	hypothesis	NOUN
finefocus-2081	98	24	-	-	PUNCT
finefocus-2081	98	25	driven	drive	VERB
finefocus-2081	98	26	experiments	experiment	NOUN
finefocus-2081	98	27	.	.	PUNCT
finefocus-2081	99	1	applying	apply	VERB
finefocus-2081	99	2	crispr	crispr	NOUN
finefocus-2081	99	3	to	to	ADP
finefocus-2081	99	4	a	a	DET
finefocus-2081	99	5	mentored	mentored	ADJ
finefocus-2081	99	6	research	research	NOUN
finefocus-2081	99	7	project	project	NOUN
finefocus-2081	99	8	provides	provide	VERB
finefocus-2081	99	9	a	a	DET
finefocus-2081	99	10	tremendous	tremendous	ADJ
finefocus-2081	99	11	opportunity	opportunity	NOUN
finefocus-2081	99	12	for	for	SCONJ
finefocus-2081	99	13	undergraduates	undergraduate	NOUN
finefocus-2081	99	14	to	to	PART
finefocus-2081	99	15	develop	develop	VERB
finefocus-2081	99	16	a	a	DET
finefocus-2081	99	17	deep	deep	ADJ
finefocus-2081	99	18	understanding	understanding	NOUN
finefocus-2081	99	19	of	of	ADP
finefocus-2081	99	20	how	how	SCONJ
finefocus-2081	99	21	genome	genome	NOUN
finefocus-2081	99	22	editing	editing	NOUN
finefocus-2081	99	23	can	can	AUX
finefocus-2081	99	24	be	be	AUX
finefocus-2081	99	25	applied	apply	VERB
finefocus-2081	99	26	to	to	ADP
finefocus-2081	99	27	a	a	DET
finefocus-2081	99	28	research	research	NOUN
finefocus-2081	99	29	problem	problem	NOUN
finefocus-2081	99	30	.	.	PUNCT
finefocus-2081	100	1	however	however	ADV
finefocus-2081	100	2	,	,	PUNCT
finefocus-2081	100	3	it	it	PRON
finefocus-2081	100	4	is	be	AUX
finefocus-2081	100	5	unrealistic	unrealistic	ADJ
finefocus-2081	100	6	to	to	PART
finefocus-2081	100	7	expect	expect	VERB
finefocus-2081	100	8	that	that	SCONJ
finefocus-2081	100	9	all	all	DET
finefocus-2081	100	10	undergraduates	undergraduate	NOUN
finefocus-2081	100	11	could	could	AUX
finefocus-2081	100	12	gain	gain	VERB
finefocus-2081	100	13	experience	experience	NOUN
finefocus-2081	100	14	in	in	ADP
finefocus-2081	100	15	this	this	DET
finefocus-2081	100	16	way	way	NOUN
finefocus-2081	100	17	.	.	PUNCT
finefocus-2081	101	1	laboratory	laboratory	NOUN
finefocus-2081	101	2	courses	course	NOUN
finefocus-2081	101	3	that	that	PRON
finefocus-2081	101	4	employ	employ	VERB
finefocus-2081	101	5	crispr	crispr	ADJ
finefocus-2081	101	6	as	as	ADP
finefocus-2081	101	7	a	a	DET
finefocus-2081	101	8	technique	technique	NOUN
finefocus-2081	101	9	are	be	AUX
finefocus-2081	101	10	an	an	DET
finefocus-2081	101	11	alternative	alternative	ADJ
finefocus-2081	101	12	method	method	NOUN
finefocus-2081	101	13	of	of	ADP
finefocus-2081	101	14	teaching	teach	VERB
finefocus-2081	101	15	undergraduate	undergraduate	NOUN
finefocus-2081	101	16	research	research	NOUN
finefocus-2081	101	17	projects	project	NOUN
finefocus-2081	101	18	crispr	crispr	ADJ
finefocus-2081	101	19	in	in	ADP
finefocus-2081	101	20	the	the	DET
finefocus-2081	101	21	classroom	classroom	NOUN
finefocus-2081	101	22	genome	genome	NOUN
finefocus-2081	101	23	editing	editing	NOUN
finefocus-2081	101	24	to	to	ADP
finefocus-2081	101	25	larger	large	ADJ
finefocus-2081	101	26	groups	group	NOUN
finefocus-2081	101	27	of	of	ADP
finefocus-2081	101	28	students	student	NOUN
finefocus-2081	101	29	.	.	PUNCT
finefocus-2081	102	1	how	how	SCONJ
finefocus-2081	102	2	crispr	crispr	NOUN
finefocus-2081	102	3	can	can	AUX
finefocus-2081	102	4	be	be	AUX
finefocus-2081	102	5	applied	apply	VERB
finefocus-2081	102	6	in	in	ADP
finefocus-2081	102	7	an	an	DET
finefocus-2081	102	8	undergraduate	undergraduate	ADJ
finefocus-2081	102	9	curriculum	curriculum	NOUN
finefocus-2081	102	10	depends	depend	VERB
finefocus-2081	102	11	upon	upon	SCONJ
finefocus-2081	102	12	the	the	DET
finefocus-2081	102	13	experience	experience	NOUN
finefocus-2081	102	14	level	level	NOUN
finefocus-2081	102	15	of	of	ADP
finefocus-2081	102	16	the	the	DET
finefocus-2081	102	17	students	student	NOUN
finefocus-2081	102	18	.	.	PUNCT
finefocus-2081	103	1	introductory	introductory	ADJ
finefocus-2081	103	2	courses	course	NOUN
finefocus-2081	103	3	pose	pose	VERB
finefocus-2081	103	4	unique	unique	ADJ
finefocus-2081	103	5	challenges	challenge	NOUN
finefocus-2081	103	6	due	due	ADP
finefocus-2081	103	7	to	to	ADP
finefocus-2081	103	8	students	student	NOUN
finefocus-2081	103	9	’	'	PUNCT
finefocus-2081	103	10	relative	relative	ADJ
finefocus-2081	103	11	unfamiliarity	unfamiliarity	NOUN
finefocus-2081	103	12	with	with	ADP
finefocus-2081	103	13	bench	bench	NOUN
finefocus-2081	103	14	science	science	NOUN
finefocus-2081	103	15	and	and	CCONJ
finefocus-2081	103	16	the	the	DET
finefocus-2081	103	17	financial	financial	ADJ
finefocus-2081	103	18	and	and	CCONJ
finefocus-2081	103	19	equipment	equipment	NOUN
finefocus-2081	103	20	constraints	constraint	NOUN
finefocus-2081	103	21	inherent	inherent	ADJ
finefocus-2081	103	22	to	to	ADP
finefocus-2081	103	23	many	many	ADJ
finefocus-2081	103	24	such	such	ADJ
finefocus-2081	103	25	courses	course	NOUN
finefocus-2081	103	26	.	.	PUNCT
finefocus-2081	104	1	thus	thus	ADV
finefocus-2081	104	2	,	,	PUNCT
finefocus-2081	104	3	it	it	PRON
finefocus-2081	104	4	is	be	AUX
finefocus-2081	104	5	important	important	ADJ
finefocus-2081	104	6	that	that	SCONJ
finefocus-2081	104	7	exercises	exercise	NOUN
finefocus-2081	104	8	yield	yield	VERB
finefocus-2081	104	9	easily	easily	ADV
finefocus-2081	104	10	interpretable	interpretable	ADJ
finefocus-2081	104	11	results	result	NOUN
finefocus-2081	104	12	while	while	SCONJ
finefocus-2081	104	13	staying	stay	VERB
finefocus-2081	104	14	within	within	ADP
finefocus-2081	104	15	the	the	DET
finefocus-2081	104	16	course	course	NOUN
finefocus-2081	104	17	’s	’s	PART
finefocus-2081	104	18	technical	technical	ADJ
finefocus-2081	104	19	and	and	CCONJ
finefocus-2081	104	20	financial	financial	ADJ
finefocus-2081	104	21	boundaries	boundary	NOUN
finefocus-2081	104	22	.	.	PUNCT
finefocus-2081	105	1	one	one	NUM
finefocus-2081	105	2	example	example	NOUN
finefocus-2081	105	3	of	of	ADP
finefocus-2081	105	4	a	a	DET
finefocus-2081	105	5	model	model	NOUN
finefocus-2081	105	6	system	system	NOUN
finefocus-2081	105	7	well	well	ADV
finefocus-2081	105	8	suited	suit	VERB
finefocus-2081	105	9	for	for	ADP
finefocus-2081	105	10	introductory	introductory	ADJ
finefocus-2081	105	11	biology	biology	NOUN
finefocus-2081	105	12	courses	course	NOUN
finefocus-2081	105	13	is	be	AUX
finefocus-2081	105	14	crisprmediated	crisprmediate	VERB
finefocus-2081	105	15	genome	genome	NOUN
finefocus-2081	105	16	editing	editing	NOUN
finefocus-2081	105	17	of	of	ADP
finefocus-2081	105	18	yeast	yeast	NOUN
finefocus-2081	105	19	ade2	ade2	PROPN
finefocus-2081	105	20	.	.	PUNCT
finefocus-2081	106	1	mutation	mutation	NOUN
finefocus-2081	106	2	of	of	ADP
finefocus-2081	106	3	s.	s.	PROPN
finefocus-2081	106	4	cerevisiae	cerevisiae	PROPN
finefocus-2081	106	5	ade2	ade2	PROPN
finefocus-2081	106	6	leads	lead	VERB
finefocus-2081	106	7	to	to	ADP
finefocus-2081	106	8	a	a	DET
finefocus-2081	106	9	buildup	buildup	NOUN
finefocus-2081	106	10	of	of	ADP
finefocus-2081	106	11	an	an	DET
finefocus-2081	106	12	adenine	adenine	ADJ
finefocus-2081	106	13	precursor	precursor	NOUN
finefocus-2081	106	14	pigmenting	pigment	VERB
finefocus-2081	106	15	the	the	DET
finefocus-2081	106	16	yeast	yeast	NOUN
finefocus-2081	106	17	red	red	NOUN
finefocus-2081	106	18	(	(	PUNCT
finefocus-2081	106	19	figure	figure	NOUN
finefocus-2081	106	20	4	4	NUM
finefocus-2081	106	21	)	)	PUNCT
finefocus-2081	106	22	(	(	PUNCT
finefocus-2081	106	23	25	25	NUM
finefocus-2081	106	24	)	)	PUNCT
finefocus-2081	106	25	.	.	PUNCT
finefocus-2081	107	1	the	the	DET
finefocus-2081	107	2	intensity	intensity	NOUN
finefocus-2081	107	3	of	of	ADP
finefocus-2081	107	4	the	the	DET
finefocus-2081	107	5	color	color	NOUN
finefocus-2081	107	6	and	and	CCONJ
finefocus-2081	107	7	efficiency	efficiency	NOUN
finefocus-2081	107	8	of	of	ADP
finefocus-2081	107	9	gene	gene	NOUN
finefocus-2081	107	10	editing	editing	NOUN
finefocus-2081	107	11	will	will	AUX
finefocus-2081	107	12	depend	depend	VERB
finefocus-2081	107	13	upon	upon	SCONJ
finefocus-2081	107	14	the	the	DET
finefocus-2081	107	15	length	length	NOUN
finefocus-2081	107	16	of	of	ADP
finefocus-2081	107	17	the	the	DET
finefocus-2081	107	18	incubation	incubation	NOUN
finefocus-2081	107	19	as	as	ADV
finefocus-2081	107	20	well	well	ADV
finefocus-2081	107	21	as	as	ADP
finefocus-2081	107	22	s.	s.	PROPN
finefocus-2081	107	23	cerevisiae	cerevisiae	PROPN
finefocus-2081	107	24	strain	strain	VERB
finefocus-2081	107	25	.	.	PUNCT
finefocus-2081	108	1	this	this	DET
finefocus-2081	108	2	easily	easily	ADV
finefocus-2081	108	3	observable	observable	ADJ
finefocus-2081	108	4	phenotype	phenotype	NOUN
finefocus-2081	108	5	,	,	PUNCT
finefocus-2081	108	6	and	and	CCONJ
finefocus-2081	108	7	the	the	DET
finefocus-2081	108	8	practicality	practicality	NOUN
finefocus-2081	108	9	of	of	ADP
finefocus-2081	108	10	yeast	yeast	NOUN
finefocus-2081	108	11	,	,	PUNCT
finefocus-2081	108	12	make	make	VERB
finefocus-2081	108	13	them	they	PRON
finefocus-2081	108	14	an	an	DET
finefocus-2081	108	15	exceptional	exceptional	ADJ
finefocus-2081	108	16	system	system	NOUN
finefocus-2081	108	17	to	to	PART
finefocus-2081	108	18	expose	expose	VERB
finefocus-2081	108	19	undergraduate	undergraduate	ADJ
finefocus-2081	108	20	students	student	NOUN
finefocus-2081	108	21	to	to	ADP
finefocus-2081	108	22	crispr	crispr	NOUN
finefocus-2081	108	23	-	-	PUNCT
finefocus-2081	108	24	mediated	mediate	VERB
finefocus-2081	108	25	genome	genome	NOUN
finefocus-2081	108	26	editing	editing	NOUN
finefocus-2081	108	27	in	in	ADP
finefocus-2081	108	28	introductory	introductory	ADJ
finefocus-2081	108	29	courses	course	NOUN
finefocus-2081	108	30	(	(	PUNCT
finefocus-2081	108	31	54	54	NUM
finefocus-2081	108	32	)	)	PUNCT
finefocus-2081	108	33	.	.	PUNCT
finefocus-2081	109	1	as	as	SCONJ
finefocus-2081	109	2	students	student	NOUN
finefocus-2081	109	3	gain	gain	VERB
finefocus-2081	109	4	more	more	ADJ
finefocus-2081	109	5	experience	experience	NOUN
finefocus-2081	109	6	,	,	PUNCT
finefocus-2081	109	7	the	the	DET
finefocus-2081	109	8	experiments	experiment	NOUN
finefocus-2081	109	9	they	they	PRON
finefocus-2081	109	10	can	can	AUX
finefocus-2081	109	11	perform	perform	VERB
finefocus-2081	109	12	and	and	CCONJ
finefocus-2081	109	13	data	datum	NOUN
finefocus-2081	109	14	they	they	PRON
finefocus-2081	109	15	can	can	AUX
finefocus-2081	109	16	interpret	interpret	VERB
finefocus-2081	109	17	during	during	ADP
finefocus-2081	109	18	laboratory	laboratory	NOUN
finefocus-2081	109	19	classes	class	NOUN
finefocus-2081	109	20	broadens	broaden	VERB
finefocus-2081	109	21	.	.	PUNCT
finefocus-2081	110	1	this	this	PRON
finefocus-2081	110	2	provides	provide	VERB
finefocus-2081	110	3	the	the	DET
finefocus-2081	110	4	instructor	instructor	NOUN
finefocus-2081	110	5	with	with	ADP
finefocus-2081	110	6	significantly	significantly	ADV
finefocus-2081	110	7	more	more	ADJ
finefocus-2081	110	8	latitude	latitude	NOUN
finefocus-2081	110	9	when	when	SCONJ
finefocus-2081	110	10	designing	designing	NOUN
finefocus-2081	110	11	exercises	exercise	NOUN
finefocus-2081	110	12	.	.	PUNCT
finefocus-2081	111	1	there	there	PRON
finefocus-2081	111	2	has	have	AUX
finefocus-2081	111	3	been	be	AUX
finefocus-2081	111	4	a	a	DET
finefocus-2081	111	5	shift	shift	NOUN
finefocus-2081	111	6	recently	recently	ADV
finefocus-2081	111	7	in	in	ADP
finefocus-2081	111	8	higher	high	ADJ
finefocus-2081	111	9	education	education	NOUN
finefocus-2081	111	10	away	away	ADV
finefocus-2081	111	11	from	from	ADP
finefocus-2081	111	12	laboratories	laboratory	NOUN
finefocus-2081	111	13	that	that	PRON
finefocus-2081	111	14	merely	merely	ADV
finefocus-2081	111	15	teach	teach	VERB
finefocus-2081	111	16	a	a	DET
finefocus-2081	111	17	technique	technique	NOUN
finefocus-2081	111	18	towards	towards	ADP
finefocus-2081	111	19	course	course	NOUN
finefocus-2081	111	20	-	-	PUNCT
finefocus-2081	111	21	based	base	VERB
finefocus-2081	111	22	undergraduate	undergraduate	NOUN
finefocus-2081	111	23	research	research	NOUN
finefocus-2081	111	24	experiences	experience	NOUN
finefocus-2081	111	25	(	(	PUNCT
finefocus-2081	111	26	cures	cure	NOUN
finefocus-2081	111	27	)	)	PUNCT
finefocus-2081	111	28	(	(	PUNCT
finefocus-2081	111	29	55	55	NUM
finefocus-2081	111	30	)	)	PUNCT
finefocus-2081	111	31	.	.	PUNCT
finefocus-2081	112	1	cures	cure	NOUN
finefocus-2081	112	2	allow	allow	VERB
finefocus-2081	112	3	students	student	NOUN
finefocus-2081	112	4	to	to	PART
finefocus-2081	112	5	develop	develop	VERB
finefocus-2081	112	6	and	and	CCONJ
finefocus-2081	112	7	address	address	VERB
finefocus-2081	112	8	a	a	DET
finefocus-2081	112	9	scientific	scientific	ADJ
finefocus-2081	112	10	question	question	NOUN
finefocus-2081	112	11	using	use	VERB
finefocus-2081	112	12	a	a	DET
finefocus-2081	112	13	variety	variety	NOUN
finefocus-2081	112	14	of	of	ADP
finefocus-2081	112	15	methodologies	methodology	NOUN
finefocus-2081	112	16	and	and	CCONJ
finefocus-2081	112	17	techniques	technique	NOUN
finefocus-2081	112	18	.	.	PUNCT
finefocus-2081	113	1	the	the	DET
finefocus-2081	113	2	speed	speed	NOUN
finefocus-2081	113	3	and	and	CCONJ
finefocus-2081	113	4	relatively	relatively	ADV
finefocus-2081	113	5	simple	simple	ADJ
finefocus-2081	113	6	nature	nature	NOUN
finefocus-2081	113	7	of	of	ADP
finefocus-2081	113	8	crispr	crispr	NOUN
finefocus-2081	113	9	-	-	PUNCT
finefocus-2081	113	10	mediated	mediate	VERB
finefocus-2081	113	11	genome	genome	NOUN
finefocus-2081	113	12	editing	editing	NOUN
finefocus-2081	113	13	makes	make	VERB
finefocus-2081	113	14	it	it	PRON
finefocus-2081	113	15	particularly	particularly	ADV
finefocus-2081	113	16	well	well	ADV
finefocus-2081	113	17	suited	suited	ADJ
finefocus-2081	113	18	for	for	ADP
finefocus-2081	113	19	upper	upper	ADJ
finefocus-2081	113	20	level	level	NOUN
finefocus-2081	113	21	biology	biology	NOUN
finefocus-2081	113	22	cures	cure	VERB
finefocus-2081	113	23	where	where	SCONJ
finefocus-2081	113	24	faculty	faculty	NOUN
finefocus-2081	113	25	address	address	NOUN
finefocus-2081	113	26	a	a	DET
finefocus-2081	113	27	research	research	NOUN
finefocus-2081	113	28	question	question	NOUN
finefocus-2081	113	29	of	of	ADP
finefocus-2081	113	30	interest	interest	NOUN
finefocus-2081	113	31	.	.	PUNCT
finefocus-2081	114	1	crispr	crispr	PROPN
finefocus-2081	114	2	based	base	VERB
finefocus-2081	114	3	cures	cure	NOUN
finefocus-2081	114	4	have	have	AUX
finefocus-2081	114	5	been	be	AUX
finefocus-2081	114	6	developed	develop	VERB
finefocus-2081	114	7	using	use	VERB
finefocus-2081	114	8	a	a	DET
finefocus-2081	114	9	variety	variety	NOUN
finefocus-2081	114	10	of	of	ADP
finefocus-2081	114	11	different	different	ADJ
finefocus-2081	114	12	model	model	NOUN
finefocus-2081	114	13	systems	system	NOUN
finefocus-2081	114	14	including	include	VERB
finefocus-2081	114	15	zebrafish	zebrafish	X
finefocus-2081	114	16	(	(	PUNCT
finefocus-2081	114	17	56	56	NUM
finefocus-2081	114	18	)	)	PUNCT
finefocus-2081	114	19	,	,	PUNCT
finefocus-2081	114	20	drosophila	drosophila	NOUN
finefocus-2081	114	21	melanogaster	melanogaster	NOUN
finefocus-2081	114	22	(	(	PUNCT
finefocus-2081	114	23	57	57	NUM
finefocus-2081	114	24	)	)	PUNCT
finefocus-2081	114	25	,	,	PUNCT
finefocus-2081	114	26	and	and	CCONJ
finefocus-2081	114	27	mammalian	mammalian	ADJ
finefocus-2081	114	28	tissue	tissue	NOUN
finefocus-2081	114	29	culture	culture	NOUN
finefocus-2081	114	30	(	(	PUNCT
finefocus-2081	114	31	58	58	NUM
finefocus-2081	114	32	)	)	PUNCT
finefocus-2081	114	33	.	.	PUNCT
finefocus-2081	115	1	the	the	DET
finefocus-2081	115	2	framework	framework	NOUN
finefocus-2081	115	3	for	for	ADP
finefocus-2081	115	4	many	many	ADJ
finefocus-2081	115	5	of	of	ADP
finefocus-2081	115	6	these	these	DET
finefocus-2081	115	7	courses	course	NOUN
finefocus-2081	115	8	is	be	AUX
finefocus-2081	115	9	similar	similar	ADJ
finefocus-2081	115	10	;	;	PUNCT
finefocus-2081	115	11	students	student	NOUN
finefocus-2081	115	12	design	design	VERB
finefocus-2081	115	13	and	and	CCONJ
finefocus-2081	115	14	clone	clone	NOUN
finefocus-2081	115	15	guide	guide	NOUN
finefocus-2081	115	16	rnas	rna	NOUN
finefocus-2081	115	17	into	into	ADP
finefocus-2081	115	18	appropriate	appropriate	ADJ
finefocus-2081	115	19	expression	expression	NOUN
finefocus-2081	115	20	vectors	vector	NOUN
finefocus-2081	115	21	and	and	CCONJ
finefocus-2081	115	22	then	then	ADV
finefocus-2081	115	23	use	use	VERB
finefocus-2081	115	24	these	these	DET
finefocus-2081	115	25	vectors	vector	NOUN
finefocus-2081	115	26	to	to	PART
finefocus-2081	115	27	edit	edit	VERB
finefocus-2081	115	28	the	the	DET
finefocus-2081	115	29	genome	genome	NOUN
finefocus-2081	115	30	of	of	ADP
finefocus-2081	115	31	their	their	PRON
finefocus-2081	115	32	model	model	NOUN
finefocus-2081	115	33	system	system	NOUN
finefocus-2081	115	34	.	.	PUNCT
finefocus-2081	116	1	these	these	DET
finefocus-2081	116	2	courses	course	NOUN
finefocus-2081	116	3	allow	allow	VERB
finefocus-2081	116	4	faculty	faculty	NOUN
finefocus-2081	116	5	to	to	PART
finefocus-2081	116	6	address	address	VERB
finefocus-2081	116	7	an	an	DET
finefocus-2081	116	8	important	important	ADJ
finefocus-2081	116	9	research	research	NOUN
finefocus-2081	116	10	question	question	NOUN
finefocus-2081	116	11	and	and	CCONJ
finefocus-2081	116	12	introduce	introduce	VERB
finefocus-2081	116	13	cutting	cut	VERB
finefocus-2081	116	14	edge	edge	NOUN
finefocus-2081	116	15	genome	genome	NOUN
finefocus-2081	116	16	editing	edit	VERB
finefocus-2081	116	17	technology	technology	NOUN
finefocus-2081	116	18	when	when	SCONJ
finefocus-2081	116	19	appropriate	appropriate	ADJ
finefocus-2081	116	20	to	to	ADP
finefocus-2081	116	21	students	student	NOUN
finefocus-2081	116	22	concurrently	concurrently	ADV
finefocus-2081	116	23	.	.	PUNCT
finefocus-2081	117	1	students	student	NOUN
finefocus-2081	117	2	then	then	ADV
finefocus-2081	117	3	assess	assess	VERB
finefocus-2081	117	4	how	how	SCONJ
finefocus-2081	117	5	edits	edit	VERB
finefocus-2081	117	6	they	they	PRON
finefocus-2081	117	7	introduce	introduce	VERB
finefocus-2081	117	8	affect	affect	VERB
finefocus-2081	117	9	phenotype	phenotype	NOUN
finefocus-2081	117	10	.	.	PUNCT
finefocus-2081	118	1	in	in	ADP
finefocus-2081	118	2	the	the	DET
finefocus-2081	118	3	case	case	NOUN
finefocus-2081	118	4	that	that	PRON
finefocus-2081	118	5	guide	guide	VERB
finefocus-2081	118	6	generation	generation	NOUN
finefocus-2081	118	7	or	or	CCONJ
finefocus-2081	118	8	editing	editing	NOUN
finefocus-2081	118	9	takes	take	VERB
finefocus-2081	118	10	longer	long	ADV
finefocus-2081	118	11	than	than	SCONJ
finefocus-2081	118	12	predicted	predict	VERB
finefocus-2081	118	13	,	,	PUNCT
finefocus-2081	118	14	phenotypic	phenotypic	ADJ
finefocus-2081	118	15	assessment	assessment	NOUN
finefocus-2081	118	16	can	can	AUX
finefocus-2081	118	17	be	be	AUX
finefocus-2081	118	18	performed	perform	VERB
finefocus-2081	118	19	in	in	ADP
finefocus-2081	118	20	other	other	ADJ
finefocus-2081	118	21	classes	class	NOUN
finefocus-2081	118	22	or	or	CCONJ
finefocus-2081	118	23	in	in	ADP
finefocus-2081	118	24	the	the	DET
finefocus-2081	118	25	research	research	NOUN
finefocus-2081	118	26	lab	lab	NOUN
finefocus-2081	118	27	of	of	ADP
finefocus-2081	118	28	the	the	DET
finefocus-2081	118	29	principal	principal	ADJ
finefocus-2081	118	30	investigator	investigator	NOUN
finefocus-2081	118	31	leading	lead	VERB
finefocus-2081	118	32	the	the	DET
finefocus-2081	118	33	exercise	exercise	NOUN
finefocus-2081	118	34	.	.	PUNCT
finefocus-2081	119	1	crispr	crispr	ADJ
finefocus-2081	119	2	•	•	NOUN
finefocus-2081	119	3	29	29	NUM
finefocus-2081	119	4	in	in	ADP
finefocus-2081	119	5	undergraduate	undergraduate	ADJ
finefocus-2081	119	6	curricula	curricula	NOUN
finefocus-2081	119	7	,	,	PUNCT
finefocus-2081	119	8	the	the	DET
finefocus-2081	119	9	most	most	ADV
finefocus-2081	119	10	immediate	immediate	ADJ
finefocus-2081	119	11	impact	impact	NOUN
finefocus-2081	119	12	of	of	ADP
finefocus-2081	119	13	cutting	cut	VERB
finefocus-2081	119	14	edge	edge	NOUN
finefocus-2081	119	15	genome	genome	NOUN
finefocus-2081	119	16	editing	editing	NOUN
finefocus-2081	119	17	technologies	technology	NOUN
finefocus-2081	119	18	like	like	ADP
finefocus-2081	119	19	crispr	crispr	PROPN
finefocus-2081	119	20	is	be	AUX
finefocus-2081	119	21	being	be	AUX
finefocus-2081	119	22	felt	feel	VERB
finefocus-2081	119	23	in	in	ADP
finefocus-2081	119	24	biology	biology	NOUN
finefocus-2081	119	25	classrooms	classroom	NOUN
finefocus-2081	119	26	as	as	ADP
finefocus-2081	119	27	the	the	DET
finefocus-2081	119	28	development	development	NOUN
finefocus-2081	119	29	of	of	ADP
finefocus-2081	119	30	genome	genome	NOUN
finefocus-2081	119	31	editing	editing	NOUN
finefocus-2081	119	32	technologies	technology	NOUN
finefocus-2081	119	33	directly	directly	ADV
finefocus-2081	119	34	affects	affect	VERB
finefocus-2081	119	35	course	course	NOUN
finefocus-2081	119	36	material	material	NOUN
finefocus-2081	119	37	being	be	AUX
finefocus-2081	119	38	taught	teach	VERB
finefocus-2081	119	39	.	.	PUNCT
finefocus-2081	120	1	however	however	ADV
finefocus-2081	120	2	,	,	PUNCT
finefocus-2081	120	3	the	the	DET
finefocus-2081	120	4	remarkable	remarkable	ADJ
finefocus-2081	120	5	rise	rise	NOUN
finefocus-2081	120	6	and	and	CCONJ
finefocus-2081	120	7	accessible	accessible	ADJ
finefocus-2081	120	8	nature	nature	NOUN
finefocus-2081	120	9	of	of	ADP
finefocus-2081	120	10	crispr	crispr	NOUN
finefocus-2081	120	11	,	,	PUNCT
finefocus-2081	120	12	combined	combine	VERB
finefocus-2081	120	13	with	with	ADP
finefocus-2081	120	14	the	the	DET
finefocus-2081	120	15	powerful	powerful	ADJ
finefocus-2081	120	16	prospect	prospect	NOUN
finefocus-2081	120	17	that	that	SCONJ
finefocus-2081	120	18	it	it	PRON
finefocus-2081	120	19	will	will	AUX
finefocus-2081	120	20	enable	enable	VERB
finefocus-2081	120	21	us	we	PRON
finefocus-2081	120	22	to	to	PART
finefocus-2081	120	23	manipulate	manipulate	VERB
finefocus-2081	120	24	genomes	genome	NOUN
finefocus-2081	120	25	at	at	ADP
finefocus-2081	120	26	will	will	NOUN
finefocus-2081	120	27	,	,	PUNCT
finefocus-2081	120	28	brings	bring	VERB
finefocus-2081	120	29	with	with	ADP
finefocus-2081	120	30	it	it	PRON
finefocus-2081	120	31	a	a	DET
finefocus-2081	120	32	variety	variety	NOUN
finefocus-2081	120	33	of	of	ADP
finefocus-2081	120	34	moral	moral	ADJ
finefocus-2081	120	35	and	and	CCONJ
finefocus-2081	120	36	ethical	ethical	ADJ
finefocus-2081	120	37	questions	question	NOUN
finefocus-2081	120	38	that	that	SCONJ
finefocus-2081	120	39	society	society	NOUN
finefocus-2081	120	40	must	must	AUX
finefocus-2081	120	41	examine	examine	VERB
finefocus-2081	120	42	.	.	PUNCT
finefocus-2081	121	1	for	for	ADP
finefocus-2081	121	2	all	all	DET
finefocus-2081	121	3	its	its	PRON
finefocus-2081	121	4	promise	promise	NOUN
finefocus-2081	121	5	,	,	PUNCT
finefocus-2081	121	6	crispr	crispr	PROPN
finefocus-2081	121	7	raises	raise	VERB
finefocus-2081	121	8	apprehension	apprehension	NOUN
finefocus-2081	121	9	regarding	regard	VERB
finefocus-2081	121	10	human	human	ADJ
finefocus-2081	121	11	germline	germline	NOUN
finefocus-2081	121	12	manipulation	manipulation	NOUN
finefocus-2081	121	13	,	,	PUNCT
finefocus-2081	121	14	unforeseen	unforeseen	ADJ
finefocus-2081	121	15	risks	risk	NOUN
finefocus-2081	121	16	,	,	PUNCT
finefocus-2081	121	17	and	and	CCONJ
finefocus-2081	121	18	the	the	DET
finefocus-2081	121	19	potential	potential	NOUN
finefocus-2081	121	20	for	for	ADP
finefocus-2081	121	21	these	these	DET
finefocus-2081	121	22	technologies	technology	NOUN
finefocus-2081	121	23	to	to	PART
finefocus-2081	121	24	further	further	ADJ
finefocus-2081	121	25	social	social	ADJ
finefocus-2081	121	26	inequities	inequity	NOUN
finefocus-2081	121	27	(	(	PUNCT
finefocus-2081	121	28	61	61	NUM
finefocus-2081	121	29	)	)	PUNCT
finefocus-2081	121	30	.	.	PUNCT
finefocus-2081	122	1	these	these	PRON
finefocus-2081	122	2	are	be	AUX
finefocus-2081	122	3	by	by	ADP
finefocus-2081	122	4	no	no	DET
finefocus-2081	122	5	means	means	NOUN
finefocus-2081	122	6	novel	novel	ADJ
finefocus-2081	122	7	concerns	concern	NOUN
finefocus-2081	122	8	;	;	PUNCT
finefocus-2081	122	9	since	since	SCONJ
finefocus-2081	122	10	generation	generation	NOUN
finefocus-2081	122	11	of	of	ADP
finefocus-2081	122	12	the	the	DET
finefocus-2081	122	13	first	first	ADJ
finefocus-2081	122	14	transgenic	transgenic	NOUN
finefocus-2081	122	15	organism	organism	NOUN
finefocus-2081	122	16	,	,	PUNCT
finefocus-2081	122	17	the	the	DET
finefocus-2081	122	18	scientific	scientific	ADJ
finefocus-2081	122	19	community	community	NOUN
finefocus-2081	122	20	has	have	AUX
finefocus-2081	122	21	debated	debate	VERB
finefocus-2081	122	22	the	the	DET
finefocus-2081	122	23	lines	line	NOUN
finefocus-2081	122	24	that	that	PRON
finefocus-2081	122	25	separate	separate	VERB
finefocus-2081	122	26	the	the	DET
finefocus-2081	122	27	unethical	unethical	ADJ
finefocus-2081	122	28	from	from	ADP
finefocus-2081	122	29	ethical	ethical	ADJ
finefocus-2081	122	30	and	and	CCONJ
finefocus-2081	122	31	the	the	DET
finefocus-2081	122	32	reckless	reckless	ADJ
finefocus-2081	122	33	from	from	ADP
finefocus-2081	122	34	the	the	DET
finefocus-2081	122	35	enthusiastic	enthusiastic	NOUN
finefocus-2081	122	36	.	.	PUNCT
finefocus-2081	123	1	while	while	SCONJ
finefocus-2081	123	2	these	these	DET
finefocus-2081	123	3	debates	debate	NOUN
finefocus-2081	123	4	continue	continue	VERB
finefocus-2081	123	5	in	in	ADP
finefocus-2081	123	6	laboratories	laboratory	NOUN
finefocus-2081	123	7	and	and	CCONJ
finefocus-2081	123	8	scientific	scientific	ADJ
finefocus-2081	123	9	conferences	conference	NOUN
finefocus-2081	123	10	across	across	ADP
finefocus-2081	123	11	the	the	DET
finefocus-2081	123	12	world	world	NOUN
finefocus-2081	123	13	,	,	PUNCT
finefocus-2081	123	14	the	the	DET
finefocus-2081	123	15	discussion	discussion	NOUN
finefocus-2081	123	16	should	should	AUX
finefocus-2081	123	17	extend	extend	VERB
finefocus-2081	123	18	beyond	beyond	ADP
finefocus-2081	123	19	the	the	DET
finefocus-2081	123	20	broader	broad	ADJ
finefocus-2081	123	21	science	science	NOUN
finefocus-2081	123	22	community	community	NOUN
finefocus-2081	123	23	to	to	ADP
finefocus-2081	123	24	the	the	DET
finefocus-2081	123	25	general	general	ADJ
finefocus-2081	123	26	public	public	NOUN
finefocus-2081	123	27	and	and	CCONJ
finefocus-2081	123	28	society	society	NOUN
finefocus-2081	123	29	at	at	ADP
finefocus-2081	123	30	large	large	ADJ
finefocus-2081	123	31	.	.	PUNCT
finefocus-2081	124	1	evidence	evidence	NOUN
finefocus-2081	124	2	for	for	ADP
finefocus-2081	124	3	this	this	DET
finefocus-2081	124	4	shift	shift	NOUN
finefocus-2081	124	5	can	can	AUX
finefocus-2081	124	6	already	already	ADV
finefocus-2081	124	7	be	be	AUX
finefocus-2081	124	8	seen	see	VERB
finefocus-2081	124	9	by	by	ADP
finefocus-2081	124	10	the	the	DET
finefocus-2081	124	11	inclusion	inclusion	NOUN
finefocus-2081	124	12	of	of	ADP
finefocus-2081	124	13	crispr	crispr	ADJ
finefocus-2081	124	14	debates	debate	NOUN
finefocus-2081	124	15	in	in	ADP
finefocus-2081	124	16	academic	academic	ADJ
finefocus-2081	124	17	courses	course	NOUN
finefocus-2081	124	18	on	on	ADP
finefocus-2081	124	19	public	public	ADJ
finefocus-2081	124	20	policy	policy	NOUN
finefocus-2081	124	21	and	and	CCONJ
finefocus-2081	124	22	science	science	NOUN
finefocus-2081	124	23	law	law	NOUN
finefocus-2081	124	24	(	(	PUNCT
finefocus-2081	124	25	62	62	NUM
finefocus-2081	124	26	,	,	PUNCT
finefocus-2081	124	27	63	63	NUM
finefocus-2081	124	28	)	)	PUNCT
finefocus-2081	124	29	.	.	PUNCT
finefocus-2081	125	1	diverse	diverse	ADJ
finefocus-2081	125	2	enrollments	enrollment	NOUN
finefocus-2081	125	3	in	in	ADP
finefocus-2081	125	4	these	these	DET
finefocus-2081	125	5	types	type	NOUN
finefocus-2081	125	6	of	of	ADP
finefocus-2081	125	7	classes	class	NOUN
finefocus-2081	125	8	will	will	AUX
finefocus-2081	125	9	provide	provide	VERB
finefocus-2081	125	10	opportunities	opportunity	NOUN
finefocus-2081	125	11	to	to	PART
finefocus-2081	125	12	engage	engage	VERB
finefocus-2081	125	13	in	in	ADP
finefocus-2081	125	14	discussions	discussion	NOUN
finefocus-2081	125	15	and	and	CCONJ
finefocus-2081	125	16	hear	hear	VERB
finefocus-2081	125	17	various	various	ADJ
finefocus-2081	125	18	viewpoints	viewpoint	NOUN
finefocus-2081	125	19	relating	relate	VERB
finefocus-2081	125	20	to	to	ADP
finefocus-2081	125	21	genome	genome	NOUN
finefocus-2081	125	22	editing	editing	NOUN
finefocus-2081	125	23	technologies	technology	NOUN
finefocus-2081	125	24	.	.	PUNCT
finefocus-2081	126	1	it	it	PRON
finefocus-2081	126	2	is	be	AUX
finefocus-2081	126	3	imperative	imperative	ADJ
finefocus-2081	126	4	that	that	SCONJ
finefocus-2081	126	5	the	the	DET
finefocus-2081	126	6	scientific	scientific	ADJ
finefocus-2081	126	7	community	community	NOUN
finefocus-2081	126	8	continue	continue	VERB
finefocus-2081	126	9	to	to	PART
finefocus-2081	126	10	inform	inform	VERB
finefocus-2081	126	11	the	the	DET
finefocus-2081	126	12	public	public	NOUN
finefocus-2081	126	13	of	of	ADP
finefocus-2081	126	14	the	the	DET
finefocus-2081	126	15	remarkable	remarkable	ADJ
finefocus-2081	126	16	promise	promise	NOUN
finefocus-2081	126	17	of	of	ADP
finefocus-2081	126	18	genome	genome	NOUN
finefocus-2081	126	19	editing	editing	NOUN
finefocus-2081	126	20	,	,	PUNCT
finefocus-2081	126	21	as	as	ADV
finefocus-2081	126	22	well	well	ADV
finefocus-2081	126	23	as	as	ADP
finefocus-2081	126	24	the	the	DET
finefocus-2081	126	25	limitations	limitation	NOUN
finefocus-2081	126	26	and	and	CCONJ
finefocus-2081	126	27	hazards	hazard	NOUN
finefocus-2081	126	28	it	it	PRON
finefocus-2081	126	29	presents	present	VERB
finefocus-2081	126	30	.	.	PUNCT
finefocus-2081	127	1	the	the	DET
finefocus-2081	127	2	inclusion	inclusion	NOUN
finefocus-2081	127	3	of	of	ADP
finefocus-2081	127	4	these	these	DET
finefocus-2081	127	5	discussions	discussion	NOUN
finefocus-2081	127	6	in	in	ADP
finefocus-2081	127	7	classrooms	classroom	NOUN
finefocus-2081	127	8	outside	outside	ADP
finefocus-2081	127	9	of	of	ADP
finefocus-2081	127	10	biology	biology	NOUN
finefocus-2081	127	11	departments	department	NOUN
finefocus-2081	127	12	will	will	AUX
finefocus-2081	127	13	provide	provide	VERB
finefocus-2081	127	14	the	the	DET
finefocus-2081	127	15	best	good	ADJ
finefocus-2081	127	16	chance	chance	NOUN
finefocus-2081	127	17	for	for	SCONJ
finefocus-2081	127	18	us	we	PRON
finefocus-2081	127	19	to	to	PART
finefocus-2081	127	20	make	make	VERB
finefocus-2081	127	21	informed	informed	ADJ
finefocus-2081	127	22	decisions	decision	NOUN
finefocus-2081	127	23	on	on	ADP
finefocus-2081	127	24	how	how	SCONJ
finefocus-2081	127	25	we	we	PRON
finefocus-2081	127	26	choose	choose	VERB
finefocus-2081	127	27	to	to	PART
finefocus-2081	127	28	apply	apply	VERB
finefocus-2081	127	29	genome	genome	NOUN
finefocus-2081	127	30	editing	editing	NOUN
finefocus-2081	127	31	technology	technology	NOUN
finefocus-2081	127	32	as	as	ADP
finefocus-2081	127	33	a	a	DET
finefocus-2081	127	34	society	society	NOUN
finefocus-2081	127	35	.	.	PUNCT
finefocus-2081	128	1	crispr	crispr	PROPN
finefocus-2081	128	2	and	and	CCONJ
finefocus-2081	128	3	science	science	NOUN
finefocus-2081	128	4	policy	policy	NOUN
finefocus-2081	128	5	another	another	DET
finefocus-2081	128	6	way	way	NOUN
finefocus-2081	128	7	crispr	crispr	ADJ
finefocus-2081	128	8	is	be	AUX
finefocus-2081	128	9	being	be	AUX
finefocus-2081	128	10	applied	apply	VERB
finefocus-2081	128	11	in	in	ADP
finefocus-2081	128	12	the	the	DET
finefocus-2081	128	13	classroom	classroom	NOUN
finefocus-2081	128	14	is	be	AUX
finefocus-2081	128	15	by	by	ADP
finefocus-2081	128	16	examining	examine	VERB
finefocus-2081	128	17	how	how	SCONJ
finefocus-2081	128	18	crispr	crispr	NOUN
finefocus-2081	128	19	helps	help	VERB
finefocus-2081	128	20	bacteria	bacteria	NOUN
finefocus-2081	128	21	defend	defend	VERB
finefocus-2081	128	22	against	against	ADP
finefocus-2081	128	23	viruses	virus	NOUN
finefocus-2081	128	24	.	.	PUNCT
finefocus-2081	129	1	for	for	ADP
finefocus-2081	129	2	example	example	NOUN
finefocus-2081	129	3	,	,	PUNCT
finefocus-2081	129	4	labs	lab	NOUN
finefocus-2081	129	5	have	have	AUX
finefocus-2081	129	6	been	be	AUX
finefocus-2081	129	7	developed	develop	VERB
finefocus-2081	129	8	where	where	SCONJ
finefocus-2081	129	9	undergraduates	undergraduate	NOUN
finefocus-2081	129	10	infect	infect	VERB
finefocus-2081	129	11	streptococcus	streptococcus	NOUN
finefocus-2081	129	12	thermophilus	thermophilus	NOUN
finefocus-2081	129	13	with	with	ADP
finefocus-2081	129	14	bacteriophage	bacteriophage	NOUN
finefocus-2081	129	15	and	and	CCONJ
finefocus-2081	129	16	sequence	sequence	NOUN
finefocus-2081	129	17	the	the	DET
finefocus-2081	129	18	bacterial	bacterial	ADJ
finefocus-2081	129	19	genomic	genomic	ADJ
finefocus-2081	129	20	dna	dna	NOUN
finefocus-2081	129	21	to	to	PART
finefocus-2081	129	22	see	see	VERB
finefocus-2081	129	23	if	if	SCONJ
finefocus-2081	129	24	viral	viral	ADJ
finefocus-2081	129	25	dna	dna	NOUN
finefocus-2081	129	26	has	have	AUX
finefocus-2081	129	27	been	be	AUX
finefocus-2081	129	28	incorporated	incorporate	VERB
finefocus-2081	129	29	to	to	ADP
finefocus-2081	129	30	the	the	DET
finefocus-2081	129	31	crispr	crispr	ADJ
finefocus-2081	129	32	array	array	NOUN
finefocus-2081	129	33	(	(	PUNCT
finefocus-2081	129	34	59	59	NUM
finefocus-2081	129	35	)	)	PUNCT
finefocus-2081	129	36	.	.	PUNCT
finefocus-2081	130	1	modified	modify	VERB
finefocus-2081	130	2	bacteria	bacteria	NOUN
finefocus-2081	130	3	gain	gain	VERB
finefocus-2081	130	4	resistance	resistance	NOUN
finefocus-2081	130	5	to	to	ADP
finefocus-2081	130	6	later	later	ADJ
finefocus-2081	130	7	phage	phage	NOUN
finefocus-2081	130	8	infections	infection	NOUN
finefocus-2081	130	9	and	and	CCONJ
finefocus-2081	130	10	subsequent	subsequent	ADJ
finefocus-2081	130	11	experiments	experiment	NOUN
finefocus-2081	130	12	can	can	AUX
finefocus-2081	130	13	be	be	AUX
finefocus-2081	130	14	performed	perform	VERB
finefocus-2081	130	15	that	that	PRON
finefocus-2081	130	16	further	far	ADV
finefocus-2081	130	17	examine	examine	VERB
finefocus-2081	130	18	the	the	DET
finefocus-2081	130	19	crisprmediated	crisprmediate	VERB
finefocus-2081	130	20	resistance	resistance	NOUN
finefocus-2081	130	21	.	.	PUNCT
finefocus-2081	131	1	furthermore	furthermore	ADV
finefocus-2081	131	2	,	,	PUNCT
finefocus-2081	131	3	cures	cure	NOUN
finefocus-2081	131	4	have	have	AUX
finefocus-2081	131	5	been	be	AUX
finefocus-2081	131	6	developed	develop	VERB
finefocus-2081	131	7	to	to	PART
finefocus-2081	131	8	identify	identify	VERB
finefocus-2081	131	9	crispr	crispr	ADJ
finefocus-2081	131	10	repeats	repeat	NOUN
finefocus-2081	131	11	in	in	ADP
finefocus-2081	131	12	uncharacterized	uncharacterized	ADJ
finefocus-2081	131	13	strains	strain	NOUN
finefocus-2081	131	14	of	of	ADP
finefocus-2081	131	15	escherichia	escherichia	NOUN
finefocus-2081	131	16	coli	coli	NOUN
finefocus-2081	131	17	(	(	PUNCT
finefocus-2081	131	18	60	60	NUM
finefocus-2081	131	19	)	)	PUNCT
finefocus-2081	131	20	.	.	PUNCT
finefocus-2081	132	1	the	the	DET
finefocus-2081	132	2	crispr	crispr	ADJ
finefocus-2081	132	3	loci	loci	NOUN
finefocus-2081	132	4	found	find	VERB
finefocus-2081	132	5	among	among	ADP
finefocus-2081	132	6	different	different	ADJ
finefocus-2081	132	7	strains	strain	NOUN
finefocus-2081	132	8	and	and	CCONJ
finefocus-2081	132	9	species	specie	NOUN
finefocus-2081	132	10	of	of	ADP
finefocus-2081	132	11	bacteria	bacteria	NOUN
finefocus-2081	132	12	should	should	AUX
finefocus-2081	132	13	be	be	AUX
finefocus-2081	132	14	distinct	distinct	ADJ
finefocus-2081	132	15	and	and	CCONJ
finefocus-2081	132	16	would	would	AUX
finefocus-2081	132	17	depend	depend	VERB
finefocus-2081	132	18	upon	upon	SCONJ
finefocus-2081	132	19	the	the	DET
finefocus-2081	132	20	viruses	virus	NOUN
finefocus-2081	132	21	they	they	PRON
finefocus-2081	132	22	have	have	AUX
finefocus-2081	132	23	encountered	encounter	VERB
finefocus-2081	132	24	.	.	PUNCT
finefocus-2081	133	1	by	by	ADP
finefocus-2081	133	2	examining	examine	VERB
finefocus-2081	133	3	the	the	DET
finefocus-2081	133	4	sequences	sequence	NOUN
finefocus-2081	133	5	of	of	ADP
finefocus-2081	133	6	crispr	crispr	ADJ
finefocus-2081	133	7	arrays	array	NOUN
finefocus-2081	133	8	,	,	PUNCT
finefocus-2081	133	9	students	student	NOUN
finefocus-2081	133	10	can	can	AUX
finefocus-2081	133	11	identify	identify	VERB
finefocus-2081	133	12	phages	phage	NOUN
finefocus-2081	133	13	the	the	DET
finefocus-2081	133	14	bacteria	bacteria	NOUN
finefocus-2081	133	15	have	have	AUX
finefocus-2081	133	16	encountered	encounter	VERB
finefocus-2081	133	17	.	.	PUNCT
finefocus-2081	134	1	while	while	SCONJ
finefocus-2081	134	2	students	student	NOUN
finefocus-2081	134	3	that	that	PRON
finefocus-2081	134	4	perform	perform	VERB
finefocus-2081	134	5	these	these	DET
finefocus-2081	134	6	exercises	exercise	NOUN
finefocus-2081	134	7	are	be	AUX
finefocus-2081	134	8	not	not	PART
finefocus-2081	134	9	editing	edit	VERB
finefocus-2081	134	10	genomes	genome	NOUN
finefocus-2081	134	11	,	,	PUNCT
finefocus-2081	134	12	they	they	PRON
finefocus-2081	134	13	learn	learn	VERB
finefocus-2081	134	14	about	about	ADP
finefocus-2081	134	15	crispr	crispr	ADJ
finefocus-2081	134	16	biochemical	biochemical	ADJ
finefocus-2081	134	17	mechanisms	mechanism	NOUN
finefocus-2081	134	18	and	and	CCONJ
finefocus-2081	134	19	gain	gain	VERB
finefocus-2081	134	20	an	an	DET
finefocus-2081	134	21	appreciation	appreciation	NOUN
finefocus-2081	134	22	for	for	ADP
finefocus-2081	134	23	how	how	SCONJ
finefocus-2081	134	24	fundamental	fundamental	ADJ
finefocus-2081	134	25	discoveries	discovery	NOUN
finefocus-2081	134	26	can	can	AUX
finefocus-2081	134	27	have	have	AUX
finefocus-2081	134	28	broad	broad	ADJ
finefocus-2081	134	29	applications	application	NOUN
finefocus-2081	134	30	.	.	PUNCT
finefocus-2081	135	1	the	the	DET
finefocus-2081	135	2	exercises	exercise	NOUN
finefocus-2081	135	3	described	describe	VERB
finefocus-2081	135	4	above	above	ADP
finefocus-2081	135	5	provide	provide	VERB
finefocus-2081	135	6	examples	example	NOUN
finefocus-2081	135	7	of	of	ADP
finefocus-2081	135	8	how	how	SCONJ
finefocus-2081	135	9	crispr	crispr	NOUN
finefocus-2081	135	10	is	be	AUX
finefocus-2081	135	11	being	be	AUX
finefocus-2081	135	12	applied	apply	VERB
finefocus-2081	135	13	to	to	ADP
finefocus-2081	135	14	undergraduate	undergraduate	NOUN
finefocus-2081	135	15	curriculum	curriculum	NOUN
finefocus-2081	135	16	.	.	PUNCT
finefocus-2081	136	1	however	however	ADV
finefocus-2081	136	2	,	,	PUNCT
finefocus-2081	136	3	crispr	crispr	NOUN
finefocus-2081	136	4	-	-	PUNCT
finefocus-2081	136	5	based	base	VERB
finefocus-2081	136	6	cures	cure	NOUN
finefocus-2081	136	7	go	go	VERB
finefocus-2081	136	8	beyond	beyond	ADP
finefocus-2081	136	9	just	just	ADV
finefocus-2081	136	10	genome	genome	NOUN
finefocus-2081	136	11	editing	editing	NOUN
finefocus-2081	136	12	,	,	PUNCT
finefocus-2081	136	13	exposing	expose	VERB
finefocus-2081	136	14	students	student	NOUN
finefocus-2081	136	15	to	to	ADP
finefocus-2081	136	16	a	a	DET
finefocus-2081	136	17	variety	variety	NOUN
finefocus-2081	136	18	of	of	ADP
finefocus-2081	136	19	other	other	ADJ
finefocus-2081	136	20	molecular	molecular	ADJ
finefocus-2081	136	21	biology	biology	NOUN
finefocus-2081	136	22	techniques	technique	NOUN
finefocus-2081	136	23	.	.	PUNCT
finefocus-2081	137	1	for	for	ADP
finefocus-2081	137	2	instance	instance	NOUN
finefocus-2081	137	3	,	,	PUNCT
finefocus-2081	137	4	to	to	PART
finefocus-2081	137	5	clone	clone	VERB
finefocus-2081	137	6	a	a	DET
finefocus-2081	137	7	guide	guide	NOUN
finefocus-2081	137	8	rna	rna	NOUN
finefocus-2081	137	9	into	into	ADP
finefocus-2081	137	10	an	an	DET
finefocus-2081	137	11	expression	expression	NOUN
finefocus-2081	137	12	vector	vector	NOUN
finefocus-2081	137	13	students	student	NOUN
finefocus-2081	137	14	need	need	VERB
finefocus-2081	137	15	to	to	PART
finefocus-2081	137	16	perform	perform	VERB
finefocus-2081	137	17	a	a	DET
finefocus-2081	137	18	variety	variety	NOUN
finefocus-2081	137	19	of	of	ADP
finefocus-2081	137	20	additional	additional	ADJ
finefocus-2081	137	21	techniques	technique	NOUN
finefocus-2081	137	22	including	include	VERB
finefocus-2081	137	23	restriction	restriction	NOUN
finefocus-2081	137	24	digestion	digestion	NOUN
finefocus-2081	137	25	,	,	PUNCT
finefocus-2081	137	26	plasmid	plasmid	ADJ
finefocus-2081	137	27	purification	purification	NOUN
finefocus-2081	137	28	,	,	PUNCT
finefocus-2081	137	29	and	and	CCONJ
finefocus-2081	137	30	dna	dna	PROPN
finefocus-2081	137	31	ligation	ligation	NOUN
finefocus-2081	137	32	.	.	PUNCT
finefocus-2081	138	1	crispr	crispr	PROPN
finefocus-2081	138	2	cures	cure	NOUN
finefocus-2081	138	3	therefore	therefore	ADV
finefocus-2081	138	4	represent	represent	VERB
finefocus-2081	138	5	comprehensive	comprehensive	ADJ
finefocus-2081	138	6	approaches	approach	NOUN
finefocus-2081	138	7	that	that	PRON
finefocus-2081	138	8	integrate	integrate	VERB
finefocus-2081	138	9	and	and	CCONJ
finefocus-2081	138	10	expose	expose	VERB
finefocus-2081	138	11	students	student	NOUN
finefocus-2081	138	12	to	to	ADP
finefocus-2081	138	13	genome	genome	NOUN
finefocus-2081	138	14	editing	editing	NOUN
finefocus-2081	138	15	and	and	CCONJ
finefocus-2081	138	16	foundational	foundational	ADJ
finefocus-2081	138	17	molecular	molecular	ADJ
finefocus-2081	138	18	biology	biology	NOUN
finefocus-2081	138	19	techniques	technique	NOUN
finefocus-2081	138	20	.	.	PUNCT
finefocus-2081	139	1	crispr	crispr	PROPN
finefocus-2081	139	2	’s	’s	PART
finefocus-2081	139	3	broad	broad	ADJ
finefocus-2081	139	4	utility	utility	NOUN
finefocus-2081	139	5	and	and	CCONJ
finefocus-2081	139	6	practicality	practicality	NOUN
finefocus-2081	139	7	make	make	VERB
finefocus-2081	139	8	crispr	crispr	ADJ
finefocus-2081	139	9	cures	cure	NOUN
finefocus-2081	139	10	attractive	attractive	ADJ
finefocus-2081	139	11	pieces	piece	NOUN
finefocus-2081	139	12	from	from	ADP
finefocus-2081	139	13	which	which	PRON
finefocus-2081	139	14	to	to	PART
finefocus-2081	139	15	shape	shape	VERB
finefocus-2081	139	16	undergraduate	undergraduate	NOUN
finefocus-2081	139	17	molecular	molecular	ADJ
finefocus-2081	139	18	biology	biology	NOUN
finefocus-2081	139	19	curricula	curricula	NOUN
finefocus-2081	139	20	.	.	PUNCT
finefocus-2081	140	1	as	as	SCONJ
finefocus-2081	140	2	crispr	crispr	PROPN
finefocus-2081	140	3	is	be	AUX
finefocus-2081	140	4	now	now	ADV
finefocus-2081	140	5	part	part	NOUN
finefocus-2081	140	6	of	of	ADP
finefocus-2081	140	7	the	the	DET
finefocus-2081	140	8	molecular	molecular	ADJ
finefocus-2081	140	9	biology	biology	NOUN
finefocus-2081	140	10	tool	tool	NOUN
finefocus-2081	140	11	box	box	PROPN
finefocus-2081	140	12	,	,	PUNCT
finefocus-2081	140	13	instructors	instructor	NOUN
finefocus-2081	140	14	should	should	AUX
finefocus-2081	140	15	consider	consider	VERB
finefocus-2081	140	16	adoption	adoption	NOUN
finefocus-2081	140	17	of	of	ADP
finefocus-2081	140	18	it	it	PRON
finefocus-2081	140	19	alongside	alongside	ADP
finefocus-2081	140	20	classic	classic	ADJ
finefocus-2081	140	21	molecular	molecular	ADJ
finefocus-2081	140	22	biology	biology	NOUN
finefocus-2081	140	23	tools	tool	NOUN
finefocus-2081	140	24	when	when	SCONJ
finefocus-2081	140	25	developing	develop	VERB
finefocus-2081	140	26	classroom	classroom	NOUN
finefocus-2081	140	27	activities	activity	NOUN
finefocus-2081	140	28	.	.	PUNCT
finefocus-2081	141	1	summary	summary	NOUN
finefocus-2081	141	2	when	when	SCONJ
finefocus-2081	141	3	the	the	DET
finefocus-2081	141	4	students	student	NOUN
finefocus-2081	141	5	involved	involve	VERB
finefocus-2081	141	6	in	in	ADP
finefocus-2081	141	7	writing	write	VERB
finefocus-2081	141	8	and	and	CCONJ
finefocus-2081	141	9	researching	research	VERB
finefocus-2081	141	10	this	this	DET
finefocus-2081	141	11	article	article	NOUN
finefocus-2081	141	12	started	start	VERB
finefocus-2081	141	13	high	high	ADJ
finefocus-2081	141	14	school	school	NOUN
finefocus-2081	141	15	,	,	PUNCT
finefocus-2081	141	16	crisprmediated	crisprmediate	VERB
finefocus-2081	141	17	genome	genome	NOUN
finefocus-2081	141	18	engineering	engineering	NOUN
finefocus-2081	141	19	had	have	AUX
finefocus-2081	141	20	not	not	PART
finefocus-2081	141	21	been	be	AUX
finefocus-2081	141	22	invented	invent	VERB
finefocus-2081	141	23	and	and	CCONJ
finefocus-2081	141	24	now	now	ADV
finefocus-2081	141	25	it	it	PRON
finefocus-2081	141	26	is	be	AUX
finefocus-2081	141	27	being	be	AUX
finefocus-2081	141	28	taught	teach	VERB
finefocus-2081	141	29	in	in	ADP
finefocus-2081	141	30	undergraduate	undergraduate	ADJ
finefocus-2081	141	31	curricula	curricula	NOUN
finefocus-2081	141	32	across	across	ADP
finefocus-2081	141	33	the	the	DET
finefocus-2081	141	34	world	world	NOUN
finefocus-2081	141	35	.	.	PUNCT
finefocus-2081	142	1	in	in	ADP
finefocus-2081	142	2	just	just	ADV
finefocus-2081	142	3	one	one	NUM
finefocus-2081	142	4	decade	decade	NOUN
finefocus-2081	142	5	,	,	PUNCT
finefocus-2081	142	6	a	a	DET
finefocus-2081	142	7	little	little	ADV
finefocus-2081	142	8	known	know	VERB
finefocus-2081	142	9	bacterial	bacterial	ADJ
finefocus-2081	142	10	immune	immune	ADJ
finefocus-2081	142	11	response	response	NOUN
finefocus-2081	142	12	has	have	AUX
finefocus-2081	142	13	profoundly	profoundly	ADV
finefocus-2081	142	14	changed	change	VERB
finefocus-2081	142	15	30	30	NUM
finefocus-2081	142	16	•	•	NUM
finefocus-2081	142	17	fine	fine	ADJ
finefocus-2081	142	18	focus	focus	NOUN
finefocus-2081	142	19	,	,	PUNCT
finefocus-2081	142	20	vol	vol	NOUN
finefocus-2081	142	21	5	5	NUM
finefocus-2081	142	22	2019	2019	NUM
finefocus-2081	142	23	the	the	DET
finefocus-2081	142	24	pace	pace	NOUN
finefocus-2081	142	25	and	and	CCONJ
finefocus-2081	142	26	breadth	breadth	NOUN
finefocus-2081	142	27	of	of	ADP
finefocus-2081	142	28	innovation	innovation	NOUN
finefocus-2081	142	29	in	in	ADP
finefocus-2081	142	30	the	the	DET
finefocus-2081	142	31	genome	genome	NOUN
finefocus-2081	142	32	editing	editing	NOUN
finefocus-2081	142	33	field	field	NOUN
finefocus-2081	142	34	has	have	AUX
finefocus-2081	142	35	made	make	VERB
finefocus-2081	142	36	it	it	PRON
finefocus-2081	142	37	challenging	challenging	ADJ
finefocus-2081	142	38	to	to	PART
finefocus-2081	142	39	include	include	VERB
finefocus-2081	142	40	all	all	DET
finefocus-2081	142	41	relevant	relevant	ADJ
finefocus-2081	142	42	work	work	NOUN
finefocus-2081	142	43	.	.	PUNCT
finefocus-2081	143	1	we	we	PRON
finefocus-2081	143	2	apologize	apologize	VERB
finefocus-2081	143	3	to	to	ADP
finefocus-2081	143	4	those	those	PRON
finefocus-2081	143	5	whose	whose	DET
finefocus-2081	143	6	work	work	NOUN
finefocus-2081	143	7	was	be	AUX
finefocus-2081	143	8	omitted	omit	VERB
finefocus-2081	143	9	.	.	PUNCT
finefocus-2081	144	1	this	this	DET
finefocus-2081	144	2	work	work	NOUN
finefocus-2081	144	3	was	be	AUX
finefocus-2081	144	4	supported	support	VERB
finefocus-2081	144	5	by	by	ADP
finefocus-2081	144	6	r15ai130950	r15ai130950	NOUN
finefocus-2081	144	7	to	to	ADP
finefocus-2081	144	8	d.a.b	d.a.b	PROPN
finefocus-2081	144	9	.	.	PUNCT
finefocus-2081	144	10	acknowledgments	acknowledgment	NOUN
finefocus-2081	144	11	research	research	NOUN
finefocus-2081	144	12	and	and	CCONJ
finefocus-2081	144	13	molecular	molecular	ADJ
finefocus-2081	144	14	biology	biology	NOUN
finefocus-2081	144	15	undergraduate	undergraduate	NOUN
finefocus-2081	144	16	education	education	NOUN
finefocus-2081	144	17	in	in	ADP
finefocus-2081	144	18	ways	way	NOUN
finefocus-2081	144	19	few	few	ADJ
finefocus-2081	144	20	envisioned	envision	VERB
finefocus-2081	144	21	.	.	PUNCT
finefocus-2081	145	1	the	the	DET
finefocus-2081	145	2	potential	potential	NOUN
finefocus-2081	145	3	for	for	ADP
finefocus-2081	145	4	crisprmediated	crisprmediate	VERB
finefocus-2081	145	5	genome	genome	NOUN
finefocus-2081	145	6	editing	editing	NOUN
finefocus-2081	145	7	to	to	PART
finefocus-2081	145	8	profoundly	profoundly	ADV
finefocus-2081	145	9	affect	affect	VERB
finefocus-2081	145	10	research	research	NOUN
finefocus-2081	145	11	,	,	PUNCT
finefocus-2081	145	12	medicine	medicine	NOUN
finefocus-2081	145	13	,	,	PUNCT
finefocus-2081	145	14	and	and	CCONJ
finefocus-2081	145	15	society	society	NOUN
finefocus-2081	145	16	over	over	ADP
finefocus-2081	145	17	the	the	DET
finefocus-2081	145	18	next	next	ADJ
finefocus-2081	145	19	decades	decade	NOUN
finefocus-2081	145	20	is	be	AUX
finefocus-2081	145	21	significant	significant	ADJ
finefocus-2081	145	22	.	.	PUNCT
finefocus-2081	146	1	the	the	DET
finefocus-2081	146	2	initial	initial	ADJ
finefocus-2081	146	3	version	version	NOUN
finefocus-2081	146	4	of	of	ADP
finefocus-2081	146	5	any	any	DET
finefocus-2081	146	6	technology	technology	NOUN
finefocus-2081	146	7	invariably	invariably	ADV
finefocus-2081	146	8	requires	require	VERB
finefocus-2081	146	9	refinement	refinement	NOUN
finefocus-2081	146	10	.	.	PUNCT
finefocus-2081	147	1	advancements	advancement	NOUN
finefocus-2081	147	2	to	to	ADP
finefocus-2081	147	3	crisprmediated	crisprmediate	VERB
finefocus-2081	147	4	genome	genome	NOUN
finefocus-2081	147	5	editing	editing	NOUN
finefocus-2081	147	6	will	will	AUX
finefocus-2081	147	7	continue	continue	VERB
finefocus-2081	147	8	as	as	ADP
finefocus-2081	147	9	more	more	ADV
finefocus-2081	147	10	bacterial	bacterial	ADJ
finefocus-2081	147	11	crispr	crispr	ADJ
finefocus-2081	147	12	systems	system	NOUN
finefocus-2081	147	13	are	be	AUX
finefocus-2081	147	14	characterized	characterize	VERB
finefocus-2081	147	15	and	and	CCONJ
finefocus-2081	147	16	the	the	DET
finefocus-2081	147	17	molecular	molecular	ADJ
finefocus-2081	147	18	biology	biology	NOUN
finefocus-2081	147	19	of	of	ADP
finefocus-2081	147	20	systems	system	NOUN
finefocus-2081	147	21	in	in	ADP
finefocus-2081	147	22	use	use	NOUN
finefocus-2081	147	23	is	be	AUX
finefocus-2081	147	24	further	far	ADV
finefocus-2081	147	25	refined	refine	VERB
finefocus-2081	147	26	.	.	PUNCT
finefocus-2081	148	1	improvements	improvement	NOUN
finefocus-2081	148	2	to	to	ADP
finefocus-2081	148	3	genome	genome	NOUN
finefocus-2081	148	4	editing	editing	NOUN
finefocus-2081	148	5	technologies	technology	NOUN
finefocus-2081	148	6	along	along	ADP
finefocus-2081	148	7	with	with	ADP
finefocus-2081	148	8	the	the	DET
finefocus-2081	148	9	likely	likely	ADJ
finefocus-2081	148	10	continued	continue	VERB
finefocus-2081	148	11	drop	drop	NOUN
finefocus-2081	148	12	in	in	ADP
finefocus-2081	148	13	the	the	DET
finefocus-2081	148	14	price	price	NOUN
finefocus-2081	148	15	of	of	ADP
finefocus-2081	148	16	gene	gene	NOUN
finefocus-2081	148	17	synthesis	synthesis	NOUN
finefocus-2081	148	18	will	will	AUX
finefocus-2081	148	19	open	open	VERB
finefocus-2081	148	20	the	the	DET
finefocus-2081	148	21	door	door	NOUN
finefocus-2081	148	22	to	to	PART
finefocus-2081	148	23	further	far	ADV
finefocus-2081	148	24	scientific	scientific	ADJ
finefocus-2081	148	25	advances	advance	NOUN
finefocus-2081	148	26	.	.	PUNCT
finefocus-2081	149	1	in	in	ADP
finefocus-2081	149	2	addition	addition	NOUN
finefocus-2081	149	3	,	,	PUNCT
finefocus-2081	149	4	as	as	SCONJ
finefocus-2081	149	5	crispr	crispr	NOUN
finefocus-2081	149	6	-	-	PUNCT
finefocus-2081	149	7	mediated	mediate	VERB
finefocus-2081	149	8	genome	genome	NOUN
finefocus-2081	149	9	editing	editing	NOUN
finefocus-2081	149	10	systems	system	NOUN
finefocus-2081	149	11	are	be	AUX
finefocus-2081	149	12	developed	develop	VERB
finefocus-2081	149	13	for	for	ADP
finefocus-2081	149	14	more	more	ADJ
finefocus-2081	149	15	organisms	organism	NOUN
finefocus-2081	149	16	,	,	PUNCT
finefocus-2081	149	17	the	the	DET
finefocus-2081	149	18	limitations	limitation	NOUN
finefocus-2081	149	19	traditional	traditional	ADJ
finefocus-2081	149	20	model	model	NOUN
finefocus-2081	149	21	systems	system	NOUN
finefocus-2081	149	22	impose	impose	VERB
finefocus-2081	149	23	on	on	ADP
finefocus-2081	149	24	research	research	NOUN
finefocus-2081	149	25	may	may	AUX
finefocus-2081	149	26	begin	begin	VERB
finefocus-2081	149	27	to	to	PART
finefocus-2081	149	28	dissipate	dissipate	VERB
finefocus-2081	149	29	.	.	PUNCT
finefocus-2081	150	1	such	such	ADJ
finefocus-2081	150	2	progress	progress	NOUN
finefocus-2081	150	3	is	be	AUX
finefocus-2081	150	4	especially	especially	ADV
finefocus-2081	150	5	exciting	exciting	ADJ
finefocus-2081	150	6	in	in	ADP
finefocus-2081	150	7	the	the	DET
finefocus-2081	150	8	context	context	NOUN
finefocus-2081	150	9	of	of	ADP
finefocus-2081	150	10	undergraduate	undergraduate	ADJ
finefocus-2081	150	11	education	education	NOUN
finefocus-2081	150	12	.	.	PUNCT
finefocus-2081	151	1	a	a	DET
finefocus-2081	151	2	recent	recent	ADJ
finefocus-2081	151	3	paradigm	paradigm	NOUN
finefocus-2081	151	4	shift	shift	NOUN
finefocus-2081	151	5	has	have	AUX
finefocus-2081	151	6	placed	place	VERB
finefocus-2081	151	7	more	more	ADJ
finefocus-2081	151	8	focus	focus	NOUN
finefocus-2081	151	9	on	on	ADP
finefocus-2081	151	10	laboratory	laboratory	NOUN
finefocus-2081	151	11	exercises	exercise	NOUN
finefocus-2081	151	12	that	that	PRON
finefocus-2081	151	13	not	not	PART
finefocus-2081	151	14	only	only	ADV
finefocus-2081	151	15	teach	teach	VERB
finefocus-2081	151	16	techniques	technique	NOUN
finefocus-2081	151	17	,	,	PUNCT
finefocus-2081	151	18	but	but	CCONJ
finefocus-2081	151	19	also	also	ADV
finefocus-2081	151	20	explore	explore	VERB
finefocus-2081	151	21	important	important	ADJ
finefocus-2081	151	22	biological	biological	ADJ
finefocus-2081	151	23	problems	problem	NOUN
finefocus-2081	151	24	through	through	ADP
finefocus-2081	151	25	guided	guide	VERB
finefocus-2081	151	26	semi	semi	ADJ
finefocus-2081	151	27	-	-	ADJ
finefocus-2081	151	28	independent	independent	ADJ
finefocus-2081	151	29	research	research	NOUN
finefocus-2081	151	30	in	in	ADP
finefocus-2081	151	31	the	the	DET
finefocus-2081	151	32	classroom	classroom	NOUN
finefocus-2081	151	33	.	.	PUNCT
finefocus-2081	152	1	the	the	DET
finefocus-2081	152	2	confluence	confluence	NOUN
finefocus-2081	152	3	of	of	ADP
finefocus-2081	152	4	this	this	DET
finefocus-2081	152	5	shift	shift	NOUN
finefocus-2081	152	6	with	with	ADP
finefocus-2081	152	7	advances	advance	NOUN
finefocus-2081	152	8	in	in	ADP
finefocus-2081	152	9	genome	genome	NOUN
finefocus-2081	152	10	editing	editing	NOUN
finefocus-2081	152	11	technology	technology	NOUN
finefocus-2081	152	12	have	have	VERB
finefocus-2081	152	13	the	the	DET
finefocus-2081	152	14	potential	potential	NOUN
finefocus-2081	152	15	to	to	PART
finefocus-2081	152	16	allow	allow	VERB
finefocus-2081	152	17	students	student	NOUN
finefocus-2081	152	18	to	to	PART
finefocus-2081	152	19	make	make	VERB
finefocus-2081	152	20	significant	significant	ADJ
finefocus-2081	152	21	progress	progress	NOUN
finefocus-2081	152	22	on	on	ADP
finefocus-2081	152	23	research	research	NOUN
finefocus-2081	152	24	questions	question	NOUN
finefocus-2081	152	25	previously	previously	ADV
finefocus-2081	152	26	impractical	impractical	ADJ
finefocus-2081	152	27	for	for	ADP
finefocus-2081	152	28	undergraduate	undergraduate	ADJ
finefocus-2081	152	29	curricula	curricula	NOUN
finefocus-2081	152	30	.	.	PUNCT
finefocus-2081	153	1	crispr	crispr	ADJ
finefocus-2081	153	2	•	•	ADV
finefocus-2081	153	3	31	31	NUM
finefocus-2081	153	4	1	1	NUM
finefocus-2081	153	5	.	.	PUNCT
finefocus-2081	154	1	jansen	jansen	PROPN
finefocus-2081	154	2	r	r	PROPN
finefocus-2081	154	3	,	,	PUNCT
finefocus-2081	154	4	embden	embden	ADJ
finefocus-2081	154	5	jd	jd	PROPN
finefocus-2081	154	6	,	,	PUNCT
finefocus-2081	154	7	gaastra	gaastra	PROPN
finefocus-2081	154	8	w	w	PROPN
finefocus-2081	154	9	,	,	PUNCT
finefocus-2081	154	10	schouls	schoul	NOUN
finefocus-2081	154	11	lm	lm	PROPN
finefocus-2081	154	12	.	.	PROPN
finefocus-2081	154	13	2002	2002	NUM
finefocus-2081	154	14	.	.	PUNCT
finefocus-2081	155	1	identification	identification	NOUN
finefocus-2081	155	2	of	of	ADP
finefocus-2081	155	3	genes	gene	NOUN
finefocus-2081	155	4	that	that	PRON
finefocus-2081	155	5	are	be	AUX
finefocus-2081	155	6	associated	associate	VERB
finefocus-2081	155	7	with	with	ADP
finefocus-2081	155	8	dna	dna	PROPN
finefocus-2081	155	9	repeats	repeat	NOUN
finefocus-2081	155	10	in	in	ADP
finefocus-2081	155	11	prokaryotes	prokaryote	NOUN
finefocus-2081	155	12	.	.	PUNCT
finefocus-2081	156	1	mol	mol	ADP
finefocus-2081	156	2	microbiol	microbiol	PROPN
finefocus-2081	156	3	43:1565	43:1565	PROPN
finefocus-2081	156	4	-	-	X
finefocus-2081	156	5	75	75	NUM
finefocus-2081	156	6	.	.	PUNCT
finefocus-2081	157	1	2	2	X
finefocus-2081	157	2	.	.	X
finefocus-2081	157	3	pourcel	pourcel	PROPN
finefocus-2081	157	4	c	c	NOUN
finefocus-2081	157	5	,	,	PUNCT
finefocus-2081	157	6	salvignol	salvignol	VERB
finefocus-2081	157	7	g	g	NOUN
finefocus-2081	157	8	,	,	PUNCT
finefocus-2081	157	9	vergnaud	vergnaud	ADJ
finefocus-2081	157	10	g.	g.	PROPN
finefocus-2081	157	11	2005	2005	NUM
finefocus-2081	157	12	.	.	PUNCT
finefocus-2081	158	1	crispr	crispr	ADJ
finefocus-2081	158	2	elements	element	NOUN
finefocus-2081	158	3	in	in	ADP
finefocus-2081	158	4	yersinia	yersinia	PROPN
finefocus-2081	158	5	pestis	pestis	PROPN
finefocus-2081	158	6	acquire	acquire	VERB
finefocus-2081	158	7	new	new	ADJ
finefocus-2081	158	8	repeats	repeat	NOUN
finefocus-2081	158	9	by	by	ADP
finefocus-2081	158	10	preferential	preferential	ADJ
finefocus-2081	158	11	uptake	uptake	NOUN
finefocus-2081	158	12	of	of	ADP
finefocus-2081	158	13	bacteriophage	bacteriophage	NOUN
finefocus-2081	158	14	dna	dna	NOUN
finefocus-2081	158	15	,	,	PUNCT
finefocus-2081	158	16	and	and	CCONJ
finefocus-2081	158	17	provide	provide	VERB
finefocus-2081	158	18	additional	additional	ADJ
finefocus-2081	158	19	tools	tool	NOUN
finefocus-2081	158	20	for	for	ADP
finefocus-2081	158	21	evolutionary	evolutionary	ADJ
finefocus-2081	158	22	studies	study	NOUN
finefocus-2081	158	23	.	.	PUNCT
finefocus-2081	159	1	microbiology	microbiology	NOUN
finefocus-2081	159	2	151:653	151:653	PROPN
finefocus-2081	159	3	-	-	SYM
finefocus-2081	159	4	63	63	NUM
finefocus-2081	159	5	.	.	PUNCT
finefocus-2081	160	1	3	3	X
finefocus-2081	160	2	.	.	X
finefocus-2081	160	3	mojica	mojica	PROPN
finefocus-2081	160	4	fj	fj	PROPN
finefocus-2081	160	5	,	,	PUNCT
finefocus-2081	160	6	diez	diez	PROPN
finefocus-2081	160	7	-	-	PUNCT
finefocus-2081	160	8	villasenor	villasenor	NOUN
finefocus-2081	160	9	c	c	PROPN
finefocus-2081	160	10	,	,	PUNCT
finefocus-2081	160	11	garcia	garcia	PROPN
finefocus-2081	160	12	-	-	PUNCT
finefocus-2081	160	13	martinez	martinez	PROPN
finefocus-2081	160	14	j	j	PROPN
finefocus-2081	160	15	,	,	PUNCT
finefocus-2081	160	16	soria	soria	PROPN
finefocus-2081	160	17	e.	e.	PROPN
finefocus-2081	160	18	2005	2005	NUM
finefocus-2081	160	19	.	.	PUNCT
finefocus-2081	161	1	intervening	intervene	VERB
finefocus-2081	161	2	sequences	sequence	NOUN
finefocus-2081	161	3	of	of	ADP
finefocus-2081	161	4	regularly	regularly	ADV
finefocus-2081	161	5	spaced	space	VERB
finefocus-2081	161	6	prokaryotic	prokaryotic	ADJ
finefocus-2081	161	7	repeats	repeat	NOUN
finefocus-2081	161	8	derive	derive	ADJ
finefocus-2081	161	9	from	from	ADP
finefocus-2081	161	10	foreign	foreign	ADJ
finefocus-2081	161	11	genetic	genetic	ADJ
finefocus-2081	161	12	elements	element	NOUN
finefocus-2081	161	13	.	.	PUNCT
finefocus-2081	162	1	j	j	PROPN
finefocus-2081	162	2	mol	mol	ADP
finefocus-2081	162	3	evol	evol	NOUN
finefocus-2081	162	4	60:174	60:174	PROPN
finefocus-2081	162	5	-	-	SYM
finefocus-2081	162	6	82	82	NUM
finefocus-2081	162	7	.	.	NOUN
finefocus-2081	162	8	4	4	X
finefocus-2081	162	9	.	.	X
finefocus-2081	162	10	brouns	brouns	PROPN
finefocus-2081	162	11	sj	sj	VERB
finefocus-2081	162	12	,	,	PUNCT
finefocus-2081	162	13	jore	jore	PROPN
finefocus-2081	162	14	mm	mm	PROPN
finefocus-2081	162	15	,	,	PUNCT
finefocus-2081	162	16	lundgren	lundgren	PROPN
finefocus-2081	162	17	m	m	PROPN
finefocus-2081	162	18	,	,	PUNCT
finefocus-2081	162	19	westra	westra	PROPN
finefocus-2081	162	20	er	er	INTJ
finefocus-2081	162	21	,	,	PUNCT
finefocus-2081	162	22	slijkhuis	slijkhuis	PROPN
finefocus-2081	162	23	rj	rj	PROPN
finefocus-2081	162	24	,	,	PUNCT
finefocus-2081	162	25	snijders	snijders	PROPN
finefocus-2081	162	26	ap	ap	PROPN
finefocus-2081	162	27	,	,	PUNCT
finefocus-2081	162	28	dickman	dickman	PROPN
finefocus-2081	162	29	mj	mj	PROPN
finefocus-2081	162	30	,	,	PUNCT
finefocus-2081	162	31	makarova	makarova	X
finefocus-2081	163	1	ks	ks	PROPN
finefocus-2081	163	2	,	,	PUNCT
finefocus-2081	163	3	koonin	koonin	ADJ
finefocus-2081	163	4	ev	ev	PROPN
finefocus-2081	163	5	,	,	PUNCT
finefocus-2081	163	6	van	van	PROPN
finefocus-2081	163	7	der	der	PROPN
finefocus-2081	163	8	oost	oost	PROPN
finefocus-2081	163	9	j.	j.	PROPN
finefocus-2081	163	10	2008	2008	NUM
finefocus-2081	163	11	.	.	PUNCT
finefocus-2081	164	1	small	small	ADJ
finefocus-2081	164	2	crispr	crispr	ADJ
finefocus-2081	164	3	rnas	rna	NOUN
finefocus-2081	164	4	guide	guide	VERB
finefocus-2081	164	5	antiviral	antiviral	ADJ
finefocus-2081	164	6	defense	defense	NOUN
finefocus-2081	164	7	in	in	ADP
finefocus-2081	164	8	prokaryotes	prokaryote	NOUN
finefocus-2081	164	9	.	.	PUNCT
finefocus-2081	165	1	science	science	NOUN
finefocus-2081	165	2	321:960	321:960	NUM
finefocus-2081	165	3	-	-	SYM
finefocus-2081	165	4	4	4	NUM
finefocus-2081	165	5	.	.	NOUN
finefocus-2081	165	6	5	5	NUM
finefocus-2081	165	7	.	.	PUNCT
finefocus-2081	166	1	hille	hille	PROPN
finefocus-2081	166	2	f	f	PROPN
finefocus-2081	166	3	,	,	PUNCT
finefocus-2081	166	4	richter	richter	PROPN
finefocus-2081	166	5	h	h	PROPN
finefocus-2081	166	6	,	,	PUNCT
finefocus-2081	166	7	wong	wong	PROPN
finefocus-2081	166	8	sp	sp	PROPN
finefocus-2081	166	9	,	,	PUNCT
finefocus-2081	166	10	bratovic	bratovic	PROPN
finefocus-2081	166	11	m	m	PROPN
finefocus-2081	166	12	,	,	PUNCT
finefocus-2081	166	13	ressel	ressel	PROPN
finefocus-2081	166	14	s	s	PROPN
finefocus-2081	166	15	,	,	PUNCT
finefocus-2081	166	16	charpentier	charpentier	PROPN
finefocus-2081	166	17	e.	e.	PROPN
finefocus-2081	166	18	2018	2018	NUM
finefocus-2081	166	19	.	.	PUNCT
finefocus-2081	167	1	the	the	DET
finefocus-2081	167	2	biology	biology	NOUN
finefocus-2081	167	3	of	of	ADP
finefocus-2081	167	4	crispr	crispr	NOUN
finefocus-2081	167	5	-	-	PUNCT
finefocus-2081	167	6	cas	cas	NOUN
finefocus-2081	167	7	:	:	PUNCT
finefocus-2081	167	8	backward	backward	ADJ
finefocus-2081	167	9	and	and	CCONJ
finefocus-2081	167	10	forward	forward	ADV
finefocus-2081	167	11	.	.	PUNCT
finefocus-2081	168	1	cell	cell	NOUN
finefocus-2081	168	2	172:1239	172:1239	NUM
finefocus-2081	168	3	-	-	SYM
finefocus-2081	168	4	1259	1259	NUM
finefocus-2081	168	5	.	.	PUNCT
finefocus-2081	169	1	6	6	NUM
finefocus-2081	169	2	.	.	X
finefocus-2081	169	3	deltcheva	deltcheva	PROPN
finefocus-2081	169	4	e	e	PROPN
finefocus-2081	169	5	,	,	PUNCT
finefocus-2081	169	6	chylinski	chylinski	PROPN
finefocus-2081	169	7	k	k	PROPN
finefocus-2081	169	8	,	,	PUNCT
finefocus-2081	169	9	sharma	sharma	PROPN
finefocus-2081	169	10	cm	cm	PROPN
finefocus-2081	169	11	,	,	PUNCT
finefocus-2081	169	12	gonzales	gonzales	PROPN
finefocus-2081	169	13	k	k	PROPN
finefocus-2081	169	14	,	,	PUNCT
finefocus-2081	169	15	chao	chao	PROPN
finefocus-2081	169	16	y	y	PROPN
finefocus-2081	169	17	,	,	PUNCT
finefocus-2081	169	18	pirzada	pirzada	PROPN
finefocus-2081	169	19	za	za	PROPN
finefocus-2081	169	20	,	,	PUNCT
finefocus-2081	169	21	eckert	eckert	PROPN
finefocus-2081	169	22	mr	mr	PROPN
finefocus-2081	169	23	,	,	PUNCT
finefocus-2081	169	24	vogel	vogel	PROPN
finefocus-2081	169	25	j	j	PROPN
finefocus-2081	169	26	,	,	PUNCT
finefocus-2081	169	27	charpentier	charpentier	PROPN
finefocus-2081	169	28	e.	e.	PROPN
finefocus-2081	169	29	2011	2011	NUM
finefocus-2081	169	30	.	.	PUNCT
finefocus-2081	170	1	crispr	crispr	PROPN
finefocus-2081	170	2	rna	rna	NOUN
finefocus-2081	170	3	maturation	maturation	NOUN
finefocus-2081	170	4	by	by	ADP
finefocus-2081	170	5	trans	tran	NOUN
finefocus-2081	170	6	-	-	VERB
finefocus-2081	170	7	encoded	encode	VERB
finefocus-2081	170	8	small	small	ADJ
finefocus-2081	170	9	rna	rna	NOUN
finefocus-2081	170	10	and	and	CCONJ
finefocus-2081	170	11	host	host	NOUN
finefocus-2081	170	12	factor	factor	NOUN
finefocus-2081	170	13	rnase	rnase	PROPN
finefocus-2081	170	14	iii	iii	PROPN
finefocus-2081	170	15	.	.	PUNCT
finefocus-2081	170	16	nature	nature	PROPN
finefocus-2081	170	17	471:602	471:602	PROPN
finefocus-2081	170	18	-	-	SYM
finefocus-2081	170	19	7	7	NUM
finefocus-2081	170	20	.	.	NOUN
finefocus-2081	170	21	7	7	NUM
finefocus-2081	170	22	.	.	X
finefocus-2081	171	1	jiang	jiang	PROPN
finefocus-2081	171	2	f	f	PROPN
finefocus-2081	171	3	,	,	PUNCT
finefocus-2081	171	4	doudna	doudna	VERB
finefocus-2081	171	5	ja	ja	PROPN
finefocus-2081	171	6	.	.	PROPN
finefocus-2081	171	7	2017	2017	NUM
finefocus-2081	171	8	.	.	PUNCT
finefocus-2081	172	1	crispr	crispr	ADJ
finefocus-2081	172	2	-	-	PUNCT
finefocus-2081	172	3	cas9	cas9	NOUN
finefocus-2081	172	4	structures	structure	NOUN
finefocus-2081	172	5	and	and	CCONJ
finefocus-2081	172	6	mechanisms	mechanism	NOUN
finefocus-2081	172	7	.	.	PUNCT
finefocus-2081	173	1	annu	annu	PROPN
finefocus-2081	173	2	rev	rev	VERB
finefocus-2081	173	3	biophys	biophy	NOUN
finefocus-2081	173	4	46:505	46:505	PROPN
finefocus-2081	173	5	-	-	SYM
finefocus-2081	173	6	529	529	NUM
finefocus-2081	173	7	.	.	NOUN
finefocus-2081	174	1	8	8	X
finefocus-2081	174	2	.	.	PUNCT
finefocus-2081	175	1	gasiunas	gasiunas	PROPN
finefocus-2081	175	2	g	g	PROPN
finefocus-2081	175	3	,	,	PUNCT
finefocus-2081	175	4	barrangou	barrangou	PROPN
finefocus-2081	175	5	r	r	PROPN
finefocus-2081	175	6	,	,	PUNCT
finefocus-2081	175	7	horvath	horvath	PROPN
finefocus-2081	175	8	p	p	PROPN
finefocus-2081	175	9	,	,	PUNCT
finefocus-2081	175	10	siksnys	siksnys	PROPN
finefocus-2081	175	11	v.	v.	ADP
finefocus-2081	175	12	2012	2012	NUM
finefocus-2081	175	13	.	.	PUNCT
finefocus-2081	176	1	cas9	cas9	NOUN
finefocus-2081	176	2	-	-	PUNCT
finefocus-2081	176	3	crrna	crrna	NOUN
finefocus-2081	176	4	ribonucleoprotein	ribonucleoprotein	NOUN
finefocus-2081	176	5	complex	complex	ADJ
finefocus-2081	176	6	mediates	mediate	NOUN
finefocus-2081	176	7	specific	specific	ADJ
finefocus-2081	176	8	dna	dna	NOUN
finefocus-2081	176	9	cleavage	cleavage	NOUN
finefocus-2081	176	10	for	for	ADP
finefocus-2081	176	11	adaptive	adaptive	ADJ
finefocus-2081	176	12	immunity	immunity	NOUN
finefocus-2081	176	13	in	in	ADP
finefocus-2081	176	14	bacteria	bacteria	NOUN
finefocus-2081	176	15	.	.	PUNCT
finefocus-2081	177	1	proc	proc	PROPN
finefocus-2081	177	2	natl	natl	PROPN
finefocus-2081	177	3	acad	acad	PROPN
finefocus-2081	177	4	sci	sci	PROPN
finefocus-2081	177	5	u	u	PROPN
finefocus-2081	177	6	s	s	PROPN
finefocus-2081	177	7	a	a	DET
finefocus-2081	177	8	109	109	NUM
finefocus-2081	177	9	:	:	PUNCT
finefocus-2081	177	10	e2579	e2579	VERB
finefocus-2081	177	11	-	-	PUNCT
finefocus-2081	177	12	86	86	NUM
finefocus-2081	177	13	.	.	PUNCT
finefocus-2081	178	1	9	9	X
finefocus-2081	178	2	.	.	X
finefocus-2081	178	3	jinek	jinek	PROPN
finefocus-2081	178	4	m	m	PROPN
finefocus-2081	178	5	,	,	PUNCT
finefocus-2081	178	6	chylinski	chylinski	PROPN
finefocus-2081	178	7	k	k	PROPN
finefocus-2081	178	8	,	,	PUNCT
finefocus-2081	178	9	fonfara	fonfara	PROPN
finefocus-2081	178	10	i	i	PRON
finefocus-2081	178	11	,	,	PUNCT
finefocus-2081	178	12	hauer	hauer	PROPN
finefocus-2081	178	13	m	m	PROPN
finefocus-2081	178	14	,	,	PUNCT
finefocus-2081	178	15	doudna	doudna	VERB
finefocus-2081	178	16	ja	ja	PROPN
finefocus-2081	178	17	,	,	PUNCT
finefocus-2081	178	18	charpentier	charpentier	PROPN
finefocus-2081	178	19	e.	e.	PROPN
finefocus-2081	178	20	2012	2012	NUM
finefocus-2081	178	21	.	.	PUNCT
finefocus-2081	179	1	a	a	DET
finefocus-2081	179	2	programmable	programmable	ADJ
finefocus-2081	179	3	dual	dual	ADJ
finefocus-2081	179	4	-	-	PUNCT
finefocus-2081	179	5	rna	rna	NOUN
finefocus-2081	179	6	-	-	PUNCT
finefocus-2081	179	7	guided	guide	VERB
finefocus-2081	179	8	dna	dna	NOUN
finefocus-2081	179	9	endonuclease	endonuclease	NOUN
finefocus-2081	179	10	in	in	ADP
finefocus-2081	179	11	adaptive	adaptive	ADJ
finefocus-2081	179	12	bacterial	bacterial	ADJ
finefocus-2081	179	13	immunity	immunity	NOUN
finefocus-2081	179	14	.	.	PUNCT
finefocus-2081	180	1	science	science	NOUN
finefocus-2081	180	2	337:816	337:816	PROPN
finefocus-2081	180	3	-	-	NOUN
finefocus-2081	180	4	21	21	NUM
finefocus-2081	180	5	.	.	PUNCT
finefocus-2081	180	6	10	10	NUM
finefocus-2081	180	7	.	.	PUNCT
finefocus-2081	181	1	mali	mali	PROPN
finefocus-2081	181	2	p	p	PROPN
finefocus-2081	181	3	,	,	PUNCT
finefocus-2081	181	4	yang	yang	PROPN
finefocus-2081	181	5	l	l	PROPN
finefocus-2081	181	6	,	,	PUNCT
finefocus-2081	181	7	esvelt	esvelt	ADJ
finefocus-2081	181	8	km	km	PROPN
finefocus-2081	181	9	,	,	PUNCT
finefocus-2081	181	10	aach	aach	PROPN
finefocus-2081	181	11	j	j	PROPN
finefocus-2081	181	12	,	,	PUNCT
finefocus-2081	181	13	guell	guell	PROPN
finefocus-2081	181	14	m	m	PROPN
finefocus-2081	181	15	,	,	PUNCT
finefocus-2081	181	16	dicarlo	dicarlo	PROPN
finefocus-2081	181	17	je	je	PROPN
finefocus-2081	181	18	,	,	PUNCT
finefocus-2081	181	19	norville	norville	PROPN
finefocus-2081	181	20	je	je	PROPN
finefocus-2081	181	21	,	,	PUNCT
finefocus-2081	181	22	church	church	NOUN
finefocus-2081	181	23	gm	gm	PROPN
finefocus-2081	181	24	.	.	PROPN
finefocus-2081	181	25	2013	2013	NUM
finefocus-2081	181	26	.	.	PUNCT
finefocus-2081	181	27	rnaguided	rnaguide	VERB
finefocus-2081	181	28	human	human	ADJ
finefocus-2081	181	29	genome	genome	NOUN
finefocus-2081	181	30	engineering	engineering	NOUN
finefocus-2081	181	31	via	via	ADP
finefocus-2081	181	32	cas9	cas9	PROPN
finefocus-2081	181	33	.	.	PUNCT
finefocus-2081	182	1	science	science	NOUN
finefocus-2081	182	2	339:823	339:823	NUM
finefocus-2081	182	3	-	-	SYM
finefocus-2081	182	4	6	6	NUM
finefocus-2081	182	5	.	.	NOUN
finefocus-2081	182	6	11	11	NUM
finefocus-2081	182	7	.	.	PUNCT
finefocus-2081	183	1	cong	cong	NOUN
finefocus-2081	183	2	l	l	PROPN
finefocus-2081	183	3	,	,	PUNCT
finefocus-2081	183	4	ran	run	VERB
finefocus-2081	183	5	fa	fa	PROPN
finefocus-2081	183	6	,	,	PUNCT
finefocus-2081	184	1	cox	cox	PROPN
finefocus-2081	184	2	d	d	PROPN
finefocus-2081	184	3	,	,	PUNCT
finefocus-2081	184	4	lin	lin	PROPN
finefocus-2081	184	5	s	s	PROPN
finefocus-2081	184	6	,	,	PUNCT
finefocus-2081	184	7	barretto	barretto	ADJ
finefocus-2081	184	8	r	r	PROPN
finefocus-2081	184	9	,	,	PUNCT
finefocus-2081	184	10	habib	habib	PROPN
finefocus-2081	184	11	n	n	CCONJ
finefocus-2081	184	12	,	,	PUNCT
finefocus-2081	184	13	hsu	hsu	PROPN
finefocus-2081	184	14	pd	pd	PROPN
finefocus-2081	184	15	,	,	PUNCT
finefocus-2081	184	16	wu	wu	PROPN
finefocus-2081	184	17	x	x	PROPN
finefocus-2081	184	18	,	,	PUNCT
finefocus-2081	184	19	jiang	jiang	PROPN
finefocus-2081	184	20	w	w	PROPN
finefocus-2081	184	21	,	,	PUNCT
finefocus-2081	184	22	marraffini	marraffini	PROPN
finefocus-2081	184	23	la	la	PROPN
finefocus-2081	184	24	,	,	PUNCT
finefocus-2081	184	25	zhang	zhang	PROPN
finefocus-2081	184	26	f.	f.	PROPN
finefocus-2081	184	27	2013	2013	NUM
finefocus-2081	184	28	.	.	PUNCT
finefocus-2081	185	1	multiplex	multiplex	NOUN
finefocus-2081	185	2	genome	genome	NOUN
finefocus-2081	185	3	engineering	engineering	NOUN
finefocus-2081	185	4	using	use	VERB
finefocus-2081	185	5	crispr	crispr	ADJ
finefocus-2081	185	6	/	/	SYM
finefocus-2081	185	7	cas	cas	NOUN
finefocus-2081	185	8	systems	system	NOUN
finefocus-2081	185	9	.	.	PUNCT
finefocus-2081	186	1	science	science	NOUN
finefocus-2081	186	2	339:819	339:819	PROPN
finefocus-2081	186	3	-	-	PUNCT
finefocus-2081	186	4	23	23	NUM
finefocus-2081	186	5	.	.	PUNCT
finefocus-2081	186	6	12	12	NUM
finefocus-2081	186	7	.	.	PUNCT
finefocus-2081	187	1	jinek	jinek	PROPN
finefocus-2081	187	2	m	m	PROPN
finefocus-2081	187	3	,	,	PUNCT
finefocus-2081	187	4	east	east	PROPN
finefocus-2081	187	5	a	a	X
finefocus-2081	187	6	,	,	PUNCT
finefocus-2081	187	7	cheng	cheng	PROPN
finefocus-2081	187	8	a	a	PROPN
finefocus-2081	187	9	,	,	PUNCT
finefocus-2081	187	10	lin	lin	PROPN
finefocus-2081	187	11	s	s	PROPN
finefocus-2081	187	12	,	,	PUNCT
finefocus-2081	187	13	ma	ma	PROPN
finefocus-2081	187	14	e	e	PROPN
finefocus-2081	187	15	,	,	PUNCT
finefocus-2081	187	16	doudna	doudna	VERB
finefocus-2081	187	17	j.	j.	PROPN
finefocus-2081	187	18	2013	2013	NUM
finefocus-2081	187	19	.	.	PUNCT
finefocus-2081	188	1	rna	rna	NOUN
finefocus-2081	188	2	-	-	PUNCT
finefocus-2081	188	3	programmed	program	VERB
finefocus-2081	188	4	genome	genome	NOUN
finefocus-2081	188	5	editing	editing	NOUN
finefocus-2081	188	6	in	in	ADP
finefocus-2081	188	7	human	human	ADJ
finefocus-2081	188	8	cells	cell	NOUN
finefocus-2081	188	9	.	.	PUNCT
finefocus-2081	189	1	elife	elife	NOUN
finefocus-2081	189	2	2	2	NUM
finefocus-2081	189	3	:	:	PUNCT
finefocus-2081	189	4	e00471	e00471	NOUN
finefocus-2081	189	5	.	.	NOUN
finefocus-2081	189	6	13	13	NUM
finefocus-2081	189	7	.	.	PUNCT
finefocus-2081	190	1	deriano	deriano	PROPN
finefocus-2081	190	2	l	l	PROPN
finefocus-2081	190	3	,	,	PUNCT
finefocus-2081	190	4	roth	roth	PROPN
finefocus-2081	190	5	db	db	PROPN
finefocus-2081	190	6	.	.	PROPN
finefocus-2081	190	7	2013	2013	NUM
finefocus-2081	190	8	.	.	PUNCT
finefocus-2081	191	1	modernizing	modernize	VERB
finefocus-2081	191	2	the	the	DET
finefocus-2081	191	3	nonhomologous	nonhomologous	ADJ
finefocus-2081	191	4	end	end	NOUN
finefocus-2081	191	5	-	-	PUNCT
finefocus-2081	191	6	joining	join	VERB
finefocus-2081	191	7	repertoire	repertoire	NOUN
finefocus-2081	191	8	:	:	PUNCT
finefocus-2081	191	9	alternative	alternative	ADJ
finefocus-2081	191	10	and	and	CCONJ
finefocus-2081	191	11	classical	classical	ADJ
finefocus-2081	191	12	nhej	nhej	ADJ
finefocus-2081	191	13	share	share	NOUN
finefocus-2081	191	14	the	the	DET
finefocus-2081	191	15	stage	stage	NOUN
finefocus-2081	191	16	.	.	PUNCT
finefocus-2081	192	1	annu	annu	PROPN
finefocus-2081	192	2	rev	rev	VERB
finefocus-2081	192	3	genet	genet	PROPN
finefocus-2081	192	4	47:433	47:433	PROPN
finefocus-2081	192	5	-	-	PROPN
finefocus-2081	192	6	55	55	NUM
finefocus-2081	192	7	.	.	PUNCT
finefocus-2081	193	1	14	14	NUM
finefocus-2081	193	2	.	.	PUNCT
finefocus-2081	194	1	greene	greene	PROPN
finefocus-2081	194	2	ec	ec	PROPN
finefocus-2081	194	3	.	.	PROPN
finefocus-2081	195	1	2016	2016	NUM
finefocus-2081	195	2	.	.	PUNCT
finefocus-2081	196	1	dna	dna	PROPN
finefocus-2081	196	2	sequence	sequence	NOUN
finefocus-2081	196	3	alignment	alignment	NOUN
finefocus-2081	196	4	during	during	ADP
finefocus-2081	196	5	homologous	homologous	ADJ
finefocus-2081	196	6	recombination	recombination	NOUN
finefocus-2081	196	7	.	.	PUNCT
finefocus-2081	197	1	j	j	PROPN
finefocus-2081	197	2	biol	biol	PROPN
finefocus-2081	197	3	chem	chem	NOUN
finefocus-2081	197	4	291:11572	291:11572	NUM
finefocus-2081	197	5	-	-	SYM
finefocus-2081	197	6	80	80	NUM
finefocus-2081	197	7	.	.	PUNCT
finefocus-2081	197	8	15	15	NUM
finefocus-2081	197	9	.	.	PUNCT
finefocus-2081	197	10	zetsche	zetsche	PROPN
finefocus-2081	197	11	b	b	PROPN
finefocus-2081	197	12	,	,	PUNCT
finefocus-2081	197	13	gootenberg	gootenberg	PROPN
finefocus-2081	197	14	js	js	PROPN
finefocus-2081	197	15	,	,	PUNCT
finefocus-2081	197	16	abudayyeh	abudayyeh	PROPN
finefocus-2081	197	17	oo	oo	INTJ
finefocus-2081	197	18	,	,	PUNCT
finefocus-2081	197	19	slaymaker	slaymaker	PROPN
finefocus-2081	197	20	i	i	PRON
finefocus-2081	197	21	m	m	PROPN
finefocus-2081	197	22	,	,	PUNCT
finefocus-2081	197	23	makarova	makarova	X
finefocus-2081	197	24	ks	ks	X
finefocus-2081	197	25	,	,	PUNCT
finefocus-2081	197	26	essletzbichler	essletzbichler	NOUN
finefocus-2081	197	27	p	p	NOUN
finefocus-2081	197	28	,	,	PUNCT
finefocus-2081	197	29	volz	volz	PROPN
finefocus-2081	197	30	se	se	PROPN
finefocus-2081	197	31	,	,	PUNCT
finefocus-2081	197	32	joung	joung	PROPN
finefocus-2081	197	33	j	j	PROPN
finefocus-2081	197	34	,	,	PUNCT
finefocus-2081	197	35	van	van	PROPN
finefocus-2081	197	36	der	der	PROPN
finefocus-2081	197	37	oost	oost	PROPN
finefocus-2081	197	38	j	j	PROPN
finefocus-2081	197	39	,	,	PUNCT
finefocus-2081	197	40	regev	regev	VERB
finefocus-2081	197	41	a	a	PRON
finefocus-2081	197	42	,	,	PUNCT
finefocus-2081	197	43	koonin	koonin	ADJ
finefocus-2081	197	44	ev	ev	ADP
finefocus-2081	197	45	,	,	PUNCT
finefocus-2081	197	46	zhang	zhang	PROPN
finefocus-2081	197	47	f.	f.	PROPN
finefocus-2081	197	48	2015	2015	NUM
finefocus-2081	197	49	.	.	PUNCT
finefocus-2081	198	1	cpf1	cpf1	PROPN
finefocus-2081	198	2	is	be	AUX
finefocus-2081	198	3	a	a	DET
finefocus-2081	198	4	single	single	ADJ
finefocus-2081	198	5	rna	rna	NOUN
finefocus-2081	198	6	-	-	PUNCT
finefocus-2081	198	7	guided	guide	VERB
finefocus-2081	198	8	endonuclease	endonuclease	NOUN
finefocus-2081	198	9	of	of	ADP
finefocus-2081	198	10	a	a	DET
finefocus-2081	198	11	class	class	NOUN
finefocus-2081	198	12	2	2	NUM
finefocus-2081	198	13	crispr	crispr	ADJ
finefocus-2081	198	14	-	-	PUNCT
finefocus-2081	198	15	cas	cas	NOUN
finefocus-2081	198	16	system	system	NOUN
finefocus-2081	198	17	.	.	PUNCT
finefocus-2081	199	1	cell	cell	NOUN
finefocus-2081	199	2	163:759	163:759	NOUN
finefocus-2081	199	3	-	-	SYM
finefocus-2081	199	4	71	71	NUM
finefocus-2081	199	5	.	.	PUNCT
finefocus-2081	200	1	16	16	NUM
finefocus-2081	200	2	.	.	PUNCT
finefocus-2081	200	3	didovyk	didovyk	PROPN
finefocus-2081	200	4	a	a	DET
finefocus-2081	200	5	,	,	PUNCT
finefocus-2081	200	6	borek	borek	PROPN
finefocus-2081	200	7	b	b	NOUN
finefocus-2081	200	8	,	,	PUNCT
finefocus-2081	200	9	tsimring	tsimre	VERB
finefocus-2081	200	10	l	l	NOUN
finefocus-2081	200	11	,	,	PUNCT
finefocus-2081	200	12	hasty	hasty	ADJ
finefocus-2081	200	13	j.	j.	PROPN
finefocus-2081	200	14	2016	2016	NUM
finefocus-2081	200	15	.	.	PUNCT
finefocus-2081	201	1	transcriptional	transcriptional	ADJ
finefocus-2081	201	2	regulation	regulation	NOUN
finefocus-2081	201	3	with	with	ADP
finefocus-2081	201	4	crispr	crispr	NOUN
finefocus-2081	201	5	-	-	PUNCT
finefocus-2081	201	6	cas9	cas9	NOUN
finefocus-2081	201	7	:	:	PUNCT
finefocus-2081	201	8	principles	principle	NOUN
finefocus-2081	201	9	,	,	PUNCT
finefocus-2081	201	10	advances	advance	NOUN
finefocus-2081	201	11	,	,	PUNCT
finefocus-2081	201	12	and	and	CCONJ
finefocus-2081	201	13	applications	application	NOUN
finefocus-2081	201	14	.	.	PUNCT
finefocus-2081	202	1	curr	curr	PROPN
finefocus-2081	202	2	opin	opin	NOUN
finefocus-2081	202	3	biotechnol	biotechnol	NOUN
finefocus-2081	202	4	40:177	40:177	PROPN
finefocus-2081	202	5	-	-	NOUN
finefocus-2081	202	6	184	184	NUM
finefocus-2081	202	7	.	.	PUNCT
finefocus-2081	202	8	17	17	NUM
finefocus-2081	202	9	.	.	PUNCT
finefocus-2081	203	1	deng	deng	PROPN
finefocus-2081	203	2	w	w	PROPN
finefocus-2081	203	3	,	,	PUNCT
finefocus-2081	203	4	shi	shi	PROPN
finefocus-2081	203	5	x	x	PROPN
finefocus-2081	203	6	,	,	PUNCT
finefocus-2081	203	7	tjian	tjian	PROPN
finefocus-2081	203	8	r	r	NOUN
finefocus-2081	203	9	,	,	PUNCT
finefocus-2081	203	10	lionnet	lionnet	PROPN
finefocus-2081	203	11	t	t	PROPN
finefocus-2081	203	12	,	,	PUNCT
finefocus-2081	203	13	singer	singer	NOUN
finefocus-2081	203	14	rh	rh	PROPN
finefocus-2081	203	15	.	.	PROPN
finefocus-2081	203	16	2015	2015	NUM
finefocus-2081	203	17	.	.	PUNCT
finefocus-2081	204	1	casfish	casfish	NOUN
finefocus-2081	204	2	:	:	PUNCT
finefocus-2081	204	3	crispr	crispr	ADJ
finefocus-2081	204	4	/	/	SYM
finefocus-2081	204	5	cas9	cas9	NOUN
finefocus-2081	204	6	-	-	PUNCT
finefocus-2081	204	7	mediated	mediate	VERB
finefocus-2081	204	8	in	in	ADP
finefocus-2081	204	9	situ	situ	ADJ
finefocus-2081	204	10	labeling	labeling	NOUN
finefocus-2081	204	11	of	of	ADP
finefocus-2081	204	12	genomic	genomic	ADJ
finefocus-2081	204	13	loci	locus	NOUN
finefocus-2081	204	14	in	in	ADP
finefocus-2081	204	15	fixed	fix	VERB
finefocus-2081	204	16	cells	cell	NOUN
finefocus-2081	204	17	.	.	PUNCT
finefocus-2081	205	1	proc	proc	PROPN
finefocus-2081	205	2	natl	natl	PROPN
finefocus-2081	205	3	acad	acad	PROPN
finefocus-2081	205	4	sci	sci	PROPN
finefocus-2081	205	5	u	u	PROPN
finefocus-2081	205	6	s	s	PROPN
finefocus-2081	205	7	a	a	DET
finefocus-2081	205	8	112:11870	112:11870	NUM
finefocus-2081	205	9	-	-	SYM
finefocus-2081	205	10	5	5	NUM
finefocus-2081	205	11	.	.	NOUN
finefocus-2081	205	12	18	18	NUM
finefocus-2081	205	13	.	.	PUNCT
finefocus-2081	206	1	jacobs	jacobs	PROPN
finefocus-2081	206	2	jz	jz	PROPN
finefocus-2081	206	3	,	,	PUNCT
finefocus-2081	206	4	ciccaglione	ciccaglione	NOUN
finefocus-2081	206	5	km	km	PROPN
finefocus-2081	206	6	,	,	PUNCT
finefocus-2081	206	7	tournier	tournier	NOUN
finefocus-2081	206	8	v	v	NOUN
finefocus-2081	206	9	,	,	PUNCT
finefocus-2081	206	10	zaratiegui	zaratiegui	PROPN
finefocus-2081	206	11	m.	m.	PROPN
finefocus-2081	206	12	2014	2014	NUM
finefocus-2081	206	13	.	.	PUNCT
finefocus-2081	207	1	implementation	implementation	NOUN
finefocus-2081	207	2	of	of	ADP
finefocus-2081	207	3	the	the	DET
finefocus-2081	207	4	crisprcas9	crisprcas9	NOUN
finefocus-2081	207	5	system	system	NOUN
finefocus-2081	207	6	in	in	ADP
finefocus-2081	207	7	fission	fission	NOUN
finefocus-2081	207	8	yeast	yeast	NOUN
finefocus-2081	207	9	.	.	PUNCT
finefocus-2081	208	1	nat	nat	PROPN
finefocus-2081	208	2	commun	commun	PROPN
finefocus-2081	208	3	5:5344	5:5344	NUM
finefocus-2081	208	4	.	.	PROPN
finefocus-2081	208	5	19	19	NUM
finefocus-2081	208	6	.	.	PUNCT
finefocus-2081	209	1	dicarlo	dicarlo	PROPN
finefocus-2081	209	2	je	je	PROPN
finefocus-2081	209	3	,	,	PUNCT
finefocus-2081	209	4	norville	norville	PROPN
finefocus-2081	209	5	je	je	PROPN
finefocus-2081	209	6	,	,	PUNCT
finefocus-2081	209	7	mali	mali	VERB
finefocus-2081	209	8	p	p	PROPN
finefocus-2081	209	9	,	,	PUNCT
finefocus-2081	209	10	rios	rios	PROPN
finefocus-2081	209	11	x	x	NOUN
finefocus-2081	209	12	,	,	PUNCT
finefocus-2081	209	13	aach	aach	PROPN
finefocus-2081	209	14	j	j	PROPN
finefocus-2081	209	15	,	,	PUNCT
finefocus-2081	209	16	church	church	NOUN
finefocus-2081	209	17	gm	gm	PROPN
finefocus-2081	209	18	.	.	PROPN
finefocus-2081	210	1	2013	2013	NUM
finefocus-2081	210	2	.	.	PUNCT
finefocus-2081	211	1	genome	genome	NOUN
finefocus-2081	211	2	engineering	engineering	NOUN
finefocus-2081	211	3	in	in	ADP
finefocus-2081	211	4	saccharomyces	saccharomyce	NOUN
finefocus-2081	211	5	cerevisiae	cerevisiae	NOUN
finefocus-2081	211	6	using	use	VERB
finefocus-2081	211	7	crispr	crispr	ADJ
finefocus-2081	211	8	-	-	PUNCT
finefocus-2081	211	9	cas	cas	NOUN
finefocus-2081	211	10	systems	system	NOUN
finefocus-2081	211	11	.	.	PUNCT
finefocus-2081	212	1	nucleic	nucleic	ADJ
finefocus-2081	212	2	acids	acid	NOUN
finefocus-2081	212	3	res	re	NOUN
finefocus-2081	212	4	41:4336	41:4336	PROPN
finefocus-2081	212	5	-	-	SYM
finefocus-2081	212	6	43	43	NUM
finefocus-2081	212	7	.	.	PUNCT
finefocus-2081	213	1	20	20	NUM
finefocus-2081	213	2	.	.	PUNCT
finefocus-2081	213	3	enkler	enkler	PROPN
finefocus-2081	213	4	l	l	PROPN
finefocus-2081	213	5	,	,	PUNCT
finefocus-2081	213	6	richer	rich	ADJ
finefocus-2081	213	7	d	d	NOUN
finefocus-2081	213	8	,	,	PUNCT
finefocus-2081	213	9	marchand	marchand	PROPN
finefocus-2081	213	10	al	al	PROPN
finefocus-2081	213	11	,	,	PUNCT
finefocus-2081	213	12	ferrandon	ferrandon	PROPN
finefocus-2081	213	13	d	d	PROPN
finefocus-2081	213	14	,	,	PUNCT
finefocus-2081	213	15	jossinet	jossinet	PROPN
finefocus-2081	213	16	f.	f.	PROPN
finefocus-2081	213	17	2016	2016	NUM
finefocus-2081	213	18	.	.	PUNCT
finefocus-2081	214	1	genome	genome	NOUN
finefocus-2081	214	2	engineering	engineering	NOUN
finefocus-2081	214	3	in	in	ADP
finefocus-2081	214	4	the	the	DET
finefocus-2081	214	5	yeast	yeast	NOUN
finefocus-2081	214	6	pathogen	pathogen	NOUN
finefocus-2081	214	7	candida	candida	PROPN
finefocus-2081	214	8	glabrata	glabrata	NOUN
finefocus-2081	214	9	using	use	VERB
finefocus-2081	214	10	the	the	DET
finefocus-2081	214	11	crispr	crispr	ADJ
finefocus-2081	214	12	-	-	PUNCT
finefocus-2081	214	13	cas9	cas9	NOUN
finefocus-2081	214	14	system	system	NOUN
finefocus-2081	214	15	.	.	PUNCT
finefocus-2081	215	1	sci	sci	PROPN
finefocus-2081	215	2	rep	rep	PROPN
finefocus-2081	215	3	6:35766	6:35766	PROPN
finefocus-2081	215	4	.	.	PROPN
finefocus-2081	216	1	21	21	NUM
finefocus-2081	216	2	.	.	PUNCT
finefocus-2081	217	1	vyas	vyas	PROPN
finefocus-2081	217	2	vk	vk	PROPN
finefocus-2081	217	3	,	,	PUNCT
finefocus-2081	217	4	barrasa	barrasa	PROPN
finefocus-2081	217	5	mi	mi	PROPN
finefocus-2081	217	6	,	,	PUNCT
finefocus-2081	217	7	fink	fink	VERB
finefocus-2081	217	8	gr	gr	PROPN
finefocus-2081	217	9	.	.	PROPN
finefocus-2081	217	10	2015	2015	NUM
finefocus-2081	217	11	.	.	PUNCT
finefocus-2081	218	1	a	a	DET
finefocus-2081	218	2	candida	candida	NOUN
finefocus-2081	218	3	albicans	albican	VERB
finefocus-2081	218	4	crispr	crispr	ADJ
finefocus-2081	218	5	system	system	NOUN
finefocus-2081	218	6	permits	permit	VERB
finefocus-2081	218	7	genetic	genetic	ADJ
finefocus-2081	218	8	engineering	engineering	NOUN
finefocus-2081	218	9	of	of	ADP
finefocus-2081	218	10	essential	essential	ADJ
finefocus-2081	218	11	genes	gene	NOUN
finefocus-2081	218	12	and	and	CCONJ
finefocus-2081	218	13	gene	gene	NOUN
finefocus-2081	218	14	families	family	NOUN
finefocus-2081	218	15	.	.	PUNCT
finefocus-2081	219	1	sci	sci	PROPN
finefocus-2081	219	2	adv	adv	PROPN
finefocus-2081	219	3	1	1	NUM
finefocus-2081	219	4	:	:	PUNCT
finefocus-2081	219	5	e1500248	e1500248	PROPN
finefocus-2081	219	6	.	.	PUNCT
finefocus-2081	220	1	22	22	NUM
finefocus-2081	220	2	.	.	PUNCT
finefocus-2081	221	1	schwartz	schwartz	PROPN
finefocus-2081	221	2	cm	cm	PROPN
finefocus-2081	221	3	,	,	PUNCT
finefocus-2081	221	4	hussain	hussain	PROPN
finefocus-2081	221	5	ms	ms	PROPN
finefocus-2081	221	6	,	,	PUNCT
finefocus-2081	221	7	blenner	blenner	NOUN
finefocus-2081	221	8	m	m	PROPN
finefocus-2081	221	9	,	,	PUNCT
finefocus-2081	221	10	wheeldon	wheeldon	PROPN
finefocus-2081	221	11	i.	i.	PROPN
finefocus-2081	221	12	2016	2016	NUM
finefocus-2081	221	13	.	.	PUNCT
finefocus-2081	222	1	synthetic	synthetic	ADJ
finefocus-2081	222	2	rna	rna	NOUN
finefocus-2081	222	3	polymerase	polymerase	NOUN
finefocus-2081	222	4	iii	iii	NUM
finefocus-2081	222	5	promoters	promoter	NOUN
finefocus-2081	222	6	facilitate	facilitate	VERB
finefocus-2081	222	7	high	high	ADJ
finefocus-2081	222	8	-	-	PUNCT
finefocus-2081	222	9	efficiency	efficiency	NOUN
finefocus-2081	222	10	crispr	crispr	NOUN
finefocus-2081	222	11	-	-	PUNCT
finefocus-2081	222	12	cas9mediated	cas9mediate	VERB
finefocus-2081	222	13	genome	genome	NOUN
finefocus-2081	222	14	editing	editing	NOUN
finefocus-2081	222	15	in	in	ADP
finefocus-2081	222	16	yarrowia	yarrowia	PROPN
finefocus-2081	222	17	lipolytica	lipolytica	PROPN
finefocus-2081	222	18	.	.	PUNCT
finefocus-2081	223	1	acs	acs	PROPN
finefocus-2081	223	2	synth	synth	ADJ
finefocus-2081	223	3	biol	biol	PROPN
finefocus-2081	223	4	5:356	5:356	NUM
finefocus-2081	223	5	-	-	SYM
finefocus-2081	223	6	9	9	NUM
finefocus-2081	223	7	.	.	NOUN
finefocus-2081	223	8	23	23	NUM
finefocus-2081	223	9	.	.	PUNCT
finefocus-2081	224	1	lee	lee	PROPN
finefocus-2081	224	2	mh	mh	PROPN
finefocus-2081	224	3	,	,	PUNCT
finefocus-2081	224	4	lin	lin	PROPN
finefocus-2081	224	5	jj	jj	PROPN
finefocus-2081	224	6	,	,	PUNCT
finefocus-2081	224	7	lin	lin	PROPN
finefocus-2081	224	8	yj	yj	PROPN
finefocus-2081	224	9	,	,	PUNCT
finefocus-2081	224	10	chang	chang	PROPN
finefocus-2081	224	11	jj	jj	PROPN
finefocus-2081	224	12	,	,	PUNCT
finefocus-2081	224	13	ke	ke	PROPN
finefocus-2081	224	14	hm	hm	PROPN
finefocus-2081	224	15	,	,	PUNCT
finefocus-2081	224	16	fan	fan	PROPN
finefocus-2081	224	17	wl	wl	PROPN
finefocus-2081	224	18	,	,	PUNCT
finefocus-2081	224	19	wang	wang	PROPN
finefocus-2081	224	20	ty	ty	PROPN
finefocus-2081	224	21	,	,	PUNCT
finefocus-2081	224	22	li	li	PROPN
finefocus-2081	224	23	wh	wh	PROPN
finefocus-2081	224	24	.	.	PROPN
finefocus-2081	224	25	2018	2018	NUM
finefocus-2081	224	26	.	.	PUNCT
finefocus-2081	225	1	genome	genome	NOUN
finefocus-2081	225	2	-	-	PUNCT
finefocus-2081	225	3	wide	wide	ADJ
finefocus-2081	225	4	prediction	prediction	NOUN
finefocus-2081	225	5	of	of	ADP
finefocus-2081	225	6	crispr	crispr	ADJ
finefocus-2081	225	7	/	/	SYM
finefocus-2081	225	8	cas9	cas9	NOUN
finefocus-2081	225	9	targets	target	NOUN
finefocus-2081	225	10	in	in	ADP
finefocus-2081	225	11	kluyveromyces	kluyveromyce	NOUN
finefocus-2081	225	12	marxianus	marxianus	PROPN
finefocus-2081	225	13	and	and	CCONJ
finefocus-2081	225	14	its	its	PRON
finefocus-2081	225	15	application	application	NOUN
finefocus-2081	225	16	to	to	PART
finefocus-2081	225	17	obtain	obtain	VERB
finefocus-2081	225	18	a	a	DET
finefocus-2081	225	19	stable	stable	ADJ
finefocus-2081	225	20	haploid	haploid	NOUN
finefocus-2081	225	21	strain	strain	NOUN
finefocus-2081	225	22	.	.	PUNCT
finefocus-2081	226	1	sci	sci	PROPN
finefocus-2081	226	2	rep	rep	PROPN
finefocus-2081	226	3	8:7305	8:7305	PROPN
finefocus-2081	226	4	.	.	PROPN
finefocus-2081	227	1	24	24	NUM
finefocus-2081	227	2	.	.	PUNCT
finefocus-2081	228	1	weninger	weninger	PROPN
finefocus-2081	228	2	a	a	DET
finefocus-2081	228	3	,	,	PUNCT
finefocus-2081	228	4	hatzl	hatzl	ADJ
finefocus-2081	228	5	am	am	NOUN
finefocus-2081	228	6	,	,	PUNCT
finefocus-2081	228	7	schmid	schmid	PROPN
finefocus-2081	228	8	c	c	PROPN
finefocus-2081	228	9	,	,	PUNCT
finefocus-2081	228	10	vogl	vogl	NOUN
finefocus-2081	228	11	t	t	PROPN
finefocus-2081	228	12	,	,	PUNCT
finefocus-2081	228	13	glieder	glieder	NOUN
finefocus-2081	228	14	a.	a.	NOUN
finefocus-2081	228	15	2016	2016	NUM
finefocus-2081	228	16	.	.	PUNCT
finefocus-2081	229	1	combinatorial	combinatorial	ADJ
finefocus-2081	229	2	optimization	optimization	NOUN
finefocus-2081	229	3	of	of	ADP
finefocus-2081	229	4	crispr	crispr	ADJ
finefocus-2081	229	5	/	/	SYM
finefocus-2081	229	6	cas9	cas9	NOUN
finefocus-2081	229	7	expression	expression	NOUN
finefocus-2081	229	8	enables	enable	VERB
finefocus-2081	229	9	precision	precision	NOUN
finefocus-2081	229	10	genome	genome	NOUN
finefocus-2081	229	11	engineering	engineering	NOUN
finefocus-2081	229	12	in	in	ADP
finefocus-2081	229	13	the	the	DET
finefocus-2081	229	14	methylotrophic	methylotrophic	ADJ
finefocus-2081	229	15	yeast	yeast	NOUN
finefocus-2081	229	16	pichia	pichia	NOUN
finefocus-2081	229	17	references	reference	NOUN
finefocus-2081	229	18	32	32	NUM
finefocus-2081	229	19	•	•	NUM
finefocus-2081	229	20	fine	fine	ADJ
finefocus-2081	229	21	focus	focus	NOUN
finefocus-2081	229	22	,	,	PUNCT
finefocus-2081	229	23	vol	vol	NOUN
finefocus-2081	229	24	5	5	NUM
finefocus-2081	229	25	2019	2019	NUM
finefocus-2081	229	26	pastoris	pastori	NOUN
finefocus-2081	229	27	.	.	PUNCT
finefocus-2081	230	1	j	j	PROPN
finefocus-2081	230	2	biotechnol	biotechnol	PROPN
finefocus-2081	230	3	235:139	235:139	PROPN
finefocus-2081	230	4	-	-	PUNCT
finefocus-2081	230	5	49	49	NUM
finefocus-2081	230	6	.	.	PUNCT
finefocus-2081	231	1	25	25	NUM
finefocus-2081	231	2	.	.	PUNCT
finefocus-2081	232	1	vyas	vyas	PROPN
finefocus-2081	232	2	vk	vk	PROPN
finefocus-2081	232	3	,	,	PUNCT
finefocus-2081	232	4	bushkin	bushkin	PROPN
finefocus-2081	232	5	gg	gg	PROPN
finefocus-2081	232	6	,	,	PUNCT
finefocus-2081	232	7	bernstein	bernstein	PROPN
finefocus-2081	232	8	da	da	PROPN
finefocus-2081	232	9	,	,	PUNCT
finefocus-2081	232	10	getz	getz	NOUN
finefocus-2081	232	11	ma	ma	PROPN
finefocus-2081	232	12	,	,	PUNCT
finefocus-2081	232	13	sewastianik	sewastianik	X
finefocus-2081	232	14	m	m	PROPN
finefocus-2081	232	15	,	,	PUNCT
finefocus-2081	232	16	barrasa	barrasa	PROPN
finefocus-2081	232	17	mi	mi	PROPN
finefocus-2081	232	18	,	,	PUNCT
finefocus-2081	232	19	bartel	bartel	PROPN
finefocus-2081	232	20	dp	dp	PROPN
finefocus-2081	232	21	,	,	PUNCT
finefocus-2081	232	22	fink	fink	VERB
finefocus-2081	232	23	gr	gr	PROPN
finefocus-2081	232	24	.	.	PROPN
finefocus-2081	232	25	2018	2018	NUM
finefocus-2081	232	26	.	.	PUNCT
finefocus-2081	233	1	new	new	ADJ
finefocus-2081	233	2	crispr	crispr	ADJ
finefocus-2081	233	3	mutagenesis	mutagenesis	NOUN
finefocus-2081	233	4	strategies	strategy	NOUN
finefocus-2081	233	5	reveal	reveal	VERB
finefocus-2081	233	6	variation	variation	NOUN
finefocus-2081	233	7	in	in	ADP
finefocus-2081	233	8	repair	repair	NOUN
finefocus-2081	233	9	mechanisms	mechanism	NOUN
finefocus-2081	233	10	among	among	ADP
finefocus-2081	233	11	fungi	fungi	PROPN
finefocus-2081	233	12	.	.	PUNCT
finefocus-2081	234	1	msphere	msphere	PROPN
finefocus-2081	234	2	3	3	NUM
finefocus-2081	234	3	.	.	PROPN
finefocus-2081	234	4	26	26	NUM
finefocus-2081	234	5	.	.	PUNCT
finefocus-2081	235	1	phithakrotchanakoon	phithakrotchanakoon	PROPN
finefocus-2081	235	2	c	c	PROPN
finefocus-2081	235	3	,	,	PUNCT
finefocus-2081	235	4	puseenam	puseenam	VERB
finefocus-2081	235	5	a	a	DET
finefocus-2081	235	6	,	,	PUNCT
finefocus-2081	235	7	wongwisansri	wongwisansri	PROPN
finefocus-2081	235	8	s	s	PROPN
finefocus-2081	235	9	,	,	PUNCT
finefocus-2081	235	10	eurwilaichitr	eurwilaichitr	ADJ
finefocus-2081	235	11	l	l	PROPN
finefocus-2081	235	12	,	,	PUNCT
finefocus-2081	235	13	ingsriswang	ingsriswang	PROPN
finefocus-2081	235	14	s	s	PART
finefocus-2081	235	15	,	,	PUNCT
finefocus-2081	235	16	tanapongpipat	tanapongpipat	VERB
finefocus-2081	235	17	s	s	PART
finefocus-2081	235	18	,	,	PUNCT
finefocus-2081	235	19	roongsawang	roongsawang	PROPN
finefocus-2081	235	20	n.	n.	PROPN
finefocus-2081	235	21	2018	2018	NUM
finefocus-2081	235	22	.	.	PUNCT
finefocus-2081	236	1	crispr	crispr	ADJ
finefocus-2081	236	2	-	-	PUNCT
finefocus-2081	236	3	cas9	cas9	NOUN
finefocus-2081	236	4	enabled	enable	VERB
finefocus-2081	236	5	targeted	target	VERB
finefocus-2081	236	6	mutagenesis	mutagenesis	NOUN
finefocus-2081	236	7	in	in	ADP
finefocus-2081	236	8	the	the	DET
finefocus-2081	236	9	thermotolerant	thermotolerant	ADJ
finefocus-2081	236	10	methylotrophic	methylotrophic	ADJ
finefocus-2081	236	11	yeast	yeast	NOUN
finefocus-2081	236	12	ogataea	ogataea	NOUN
finefocus-2081	236	13	thermomethanolica	thermomethanolica	NOUN
finefocus-2081	236	14	.	.	PUNCT
finefocus-2081	237	1	fems	fems	PROPN
finefocus-2081	237	2	microbiol	microbiol	PROPN
finefocus-2081	237	3	lett	lett	NOUN
finefocus-2081	237	4	365	365	NUM
finefocus-2081	237	5	.	.	PUNCT
finefocus-2081	237	6	27	27	NUM
finefocus-2081	237	7	.	.	PUNCT
finefocus-2081	238	1	norton	norton	PROPN
finefocus-2081	238	2	el	el	PROPN
finefocus-2081	238	3	,	,	PUNCT
finefocus-2081	238	4	sherwood	sherwood	PROPN
finefocus-2081	238	5	rk	rk	PROPN
finefocus-2081	238	6	,	,	PUNCT
finefocus-2081	238	7	bennett	bennett	PROPN
finefocus-2081	238	8	rj	rj	PROPN
finefocus-2081	238	9	.	.	PROPN
finefocus-2081	238	10	2017	2017	NUM
finefocus-2081	238	11	.	.	PUNCT
finefocus-2081	239	1	development	development	NOUN
finefocus-2081	239	2	of	of	ADP
finefocus-2081	239	3	a	a	DET
finefocus-2081	239	4	crispr	crispr	ADJ
finefocus-2081	239	5	-	-	PUNCT
finefocus-2081	239	6	cas9	cas9	NOUN
finefocus-2081	239	7	system	system	NOUN
finefocus-2081	239	8	for	for	ADP
finefocus-2081	239	9	efficient	efficient	ADJ
finefocus-2081	239	10	genome	genome	NOUN
finefocus-2081	239	11	editing	editing	NOUN
finefocus-2081	239	12	of	of	ADP
finefocus-2081	239	13	candida	candida	PROPN
finefocus-2081	239	14	lusitaniae	lusitaniae	PROPN
finefocus-2081	239	15	.	.	PUNCT
finefocus-2081	239	16	msphere	msphere	PROPN
finefocus-2081	239	17	2	2	NUM
finefocus-2081	239	18	.	.	NOUN
finefocus-2081	239	19	28	28	NUM
finefocus-2081	239	20	.	.	PUNCT
finefocus-2081	240	1	lombardi	lombardi	PROPN
finefocus-2081	240	2	l	l	PROPN
finefocus-2081	240	3	,	,	PUNCT
finefocus-2081	240	4	turner	turner	PROPN
finefocus-2081	240	5	sa	sa	PROPN
finefocus-2081	240	6	,	,	PUNCT
finefocus-2081	240	7	zhao	zhao	PROPN
finefocus-2081	240	8	f	f	PROPN
finefocus-2081	240	9	,	,	PUNCT
finefocus-2081	240	10	butler	butler	PROPN
finefocus-2081	240	11	g.	g.	PROPN
finefocus-2081	240	12	2017	2017	NUM
finefocus-2081	240	13	.	.	PUNCT
finefocus-2081	241	1	gene	gene	NOUN
finefocus-2081	241	2	editing	edit	VERB
finefocus-2081	241	3	in	in	ADP
finefocus-2081	241	4	clinical	clinical	ADJ
finefocus-2081	241	5	isolates	isolate	NOUN
finefocus-2081	241	6	of	of	ADP
finefocus-2081	241	7	candida	candida	NOUN
finefocus-2081	241	8	parapsilosis	parapsilosis	NOUN
finefocus-2081	241	9	using	use	VERB
finefocus-2081	241	10	crispr	crispr	NOUN
finefocus-2081	241	11	/	/	SYM
finefocus-2081	241	12	cas9	cas9	NOUN
finefocus-2081	241	13	.	.	PUNCT
finefocus-2081	242	1	sci	sci	PROPN
finefocus-2081	242	2	rep	rep	PROPN
finefocus-2081	242	3	7:8051	7:8051	PROPN
finefocus-2081	242	4	.	.	PROPN
finefocus-2081	242	5	29	29	NUM
finefocus-2081	242	6	.	.	PUNCT
finefocus-2081	243	1	chen	chen	PROPN
finefocus-2081	243	2	bx	bx	PROPN
finefocus-2081	243	3	,	,	PUNCT
finefocus-2081	243	4	wei	wei	PROPN
finefocus-2081	243	5	t	t	PROPN
finefocus-2081	243	6	,	,	PUNCT
finefocus-2081	243	7	ye	ye	PROPN
finefocus-2081	243	8	zw	zw	PROPN
finefocus-2081	243	9	,	,	PUNCT
finefocus-2081	243	10	yun	yun	PROPN
finefocus-2081	243	11	f	f	PROPN
finefocus-2081	243	12	,	,	PUNCT
finefocus-2081	243	13	kang	kang	PROPN
finefocus-2081	243	14	lz	lz	PROPN
finefocus-2081	243	15	,	,	PUNCT
finefocus-2081	243	16	tang	tang	PROPN
finefocus-2081	243	17	hb	hb	PROPN
finefocus-2081	243	18	,	,	PUNCT
finefocus-2081	243	19	guo	guo	PROPN
finefocus-2081	243	20	lq	lq	PROPN
finefocus-2081	243	21	,	,	PUNCT
finefocus-2081	243	22	lin	lin	PROPN
finefocus-2081	243	23	jf	jf	PROPN
finefocus-2081	243	24	.	.	PROPN
finefocus-2081	243	25	2018	2018	NUM
finefocus-2081	243	26	.	.	PUNCT
finefocus-2081	244	1	efficient	efficient	ADJ
finefocus-2081	244	2	crisprcas9	crisprcas9	NOUN
finefocus-2081	244	3	gene	gene	NOUN
finefocus-2081	244	4	disruption	disruption	NOUN
finefocus-2081	244	5	system	system	NOUN
finefocus-2081	244	6	in	in	ADP
finefocus-2081	244	7	edible	edible	ADJ
finefocus-2081	244	8	-	-	PUNCT
finefocus-2081	244	9	medicinal	medicinal	ADJ
finefocus-2081	244	10	mushroom	mushroom	NOUN
finefocus-2081	244	11	cordyceps	cordycep	NOUN
finefocus-2081	244	12	militaris	militaris	NOUN
finefocus-2081	244	13	.	.	PROPN
finefocus-2081	245	1	front	front	PROPN
finefocus-2081	245	2	microbiol	microbiol	PROPN
finefocus-2081	245	3	9:1157	9:1157	NUM
finefocus-2081	245	4	.	.	PUNCT
finefocus-2081	246	1	30	30	NUM
finefocus-2081	246	2	.	.	PUNCT
finefocus-2081	247	1	arras	arras	PROPN
finefocus-2081	247	2	sd	sd	PROPN
finefocus-2081	247	3	,	,	PUNCT
finefocus-2081	247	4	chua	chua	PROPN
finefocus-2081	247	5	sm	sm	PROPN
finefocus-2081	247	6	,	,	PUNCT
finefocus-2081	247	7	wizrah	wizrah	PROPN
finefocus-2081	247	8	ms	ms	PROPN
finefocus-2081	247	9	,	,	PUNCT
finefocus-2081	247	10	faint	faint	ADJ
finefocus-2081	247	11	ja	ja	PROPN
finefocus-2081	247	12	,	,	PUNCT
finefocus-2081	247	13	yap	yap	PROPN
finefocus-2081	247	14	as	as	ADP
finefocus-2081	247	15	,	,	PUNCT
finefocus-2081	247	16	fraser	fraser	PROPN
finefocus-2081	247	17	ja	ja	PROPN
finefocus-2081	247	18	.	.	PROPN
finefocus-2081	247	19	2016	2016	NUM
finefocus-2081	247	20	.	.	PUNCT
finefocus-2081	248	1	targeted	target	VERB
finefocus-2081	248	2	genome	genome	NOUN
finefocus-2081	248	3	editing	editing	NOUN
finefocus-2081	248	4	via	via	ADP
finefocus-2081	248	5	crispr	crispr	NOUN
finefocus-2081	248	6	in	in	ADP
finefocus-2081	248	7	the	the	DET
finefocus-2081	248	8	pathogen	pathogen	NOUN
finefocus-2081	248	9	cryptococcus	cryptococcus	NOUN
finefocus-2081	248	10	neoformans	neoforman	NOUN
finefocus-2081	248	11	.	.	PUNCT
finefocus-2081	249	1	plos	plos	PROPN
finefocus-2081	249	2	one	one	NUM
finefocus-2081	249	3	11	11	NUM
finefocus-2081	249	4	:	:	PUNCT
finefocus-2081	249	5	e0164322	e0164322	PROPN
finefocus-2081	249	6	.	.	PROPN
finefocus-2081	249	7	31	31	NUM
finefocus-2081	249	8	.	.	PUNCT
finefocus-2081	250	1	cao	cao	PROPN
finefocus-2081	250	2	m	m	PROPN
finefocus-2081	250	3	,	,	PUNCT
finefocus-2081	250	4	gao	gao	PROPN
finefocus-2081	250	5	m	m	PROPN
finefocus-2081	250	6	,	,	PUNCT
finefocus-2081	250	7	ploessl	ploessl	PROPN
finefocus-2081	250	8	d	d	NOUN
finefocus-2081	250	9	,	,	PUNCT
finefocus-2081	250	10	song	song	NOUN
finefocus-2081	250	11	c	c	PROPN
finefocus-2081	250	12	,	,	PUNCT
finefocus-2081	250	13	shao	shao	PROPN
finefocus-2081	250	14	z.	z.	PROPN
finefocus-2081	250	15	2018	2018	NUM
finefocus-2081	250	16	.	.	PUNCT
finefocus-2081	251	1	crispr	crispr	NOUN
finefocus-2081	251	2	-	-	PUNCT
finefocus-2081	251	3	mediated	mediate	VERB
finefocus-2081	251	4	genome	genome	NOUN
finefocus-2081	251	5	editing	editing	NOUN
finefocus-2081	251	6	and	and	CCONJ
finefocus-2081	251	7	gene	gene	NOUN
finefocus-2081	251	8	repression	repression	NOUN
finefocus-2081	251	9	in	in	ADP
finefocus-2081	251	10	scheffersomyces	scheffersomyce	NOUN
finefocus-2081	251	11	stipitis	stipitis	PROPN
finefocus-2081	251	12	.	.	PUNCT
finefocus-2081	252	1	biotechnol	biotechnol	PROPN
finefocus-2081	252	2	j	j	PROPN
finefocus-2081	252	3	doi:10.1002	doi:10.1002	NOUN
finefocus-2081	252	4	/	/	SYM
finefocus-2081	252	5	biot.201700598	biot.201700598	ADJ
finefocus-2081	252	6	:	:	PUNCT
finefocus-2081	252	7	e1700598	e1700598	ADJ
finefocus-2081	252	8	.	.	PUNCT
finefocus-2081	253	1	32	32	NUM
finefocus-2081	253	2	.	.	PUNCT
finefocus-2081	253	3	fuller	full	ADJ
finefocus-2081	253	4	kk	kk	PROPN
finefocus-2081	253	5	,	,	PUNCT
finefocus-2081	253	6	chen	chen	PROPN
finefocus-2081	253	7	s	s	PROPN
finefocus-2081	253	8	,	,	PUNCT
finefocus-2081	253	9	loros	loros	PROPN
finefocus-2081	253	10	jj	jj	PROPN
finefocus-2081	253	11	,	,	PUNCT
finefocus-2081	253	12	dunlap	dunlap	PROPN
finefocus-2081	253	13	jc	jc	PROPN
finefocus-2081	253	14	.	.	PROPN
finefocus-2081	253	15	2015	2015	NUM
finefocus-2081	253	16	.	.	PUNCT
finefocus-2081	254	1	development	development	NOUN
finefocus-2081	254	2	of	of	ADP
finefocus-2081	254	3	the	the	DET
finefocus-2081	254	4	crispr	crispr	ADJ
finefocus-2081	254	5	/	/	SYM
finefocus-2081	254	6	cas9	cas9	NOUN
finefocus-2081	254	7	system	system	NOUN
finefocus-2081	254	8	for	for	ADP
finefocus-2081	254	9	targeted	target	VERB
finefocus-2081	254	10	gene	gene	NOUN
finefocus-2081	254	11	disruption	disruption	NOUN
finefocus-2081	254	12	in	in	ADP
finefocus-2081	254	13	aspergillus	aspergillus	ADJ
finefocus-2081	254	14	fumigatus	fumigatus	NOUN
finefocus-2081	254	15	.	.	PUNCT
finefocus-2081	255	1	eukaryot	eukaryot	PROPN
finefocus-2081	255	2	cell	cell	NOUN
finefocus-2081	255	3	14:1073	14:1073	NUM
finefocus-2081	255	4	-	-	SYM
finefocus-2081	255	5	80	80	NUM
finefocus-2081	255	6	.	.	PUNCT
finefocus-2081	256	1	33	33	NUM
finefocus-2081	256	2	.	.	PUNCT
finefocus-2081	257	1	komor	komor	PROPN
finefocus-2081	257	2	ac	ac	PROPN
finefocus-2081	257	3	,	,	PUNCT
finefocus-2081	257	4	badran	badran	VERB
finefocus-2081	257	5	ah	ah	INTJ
finefocus-2081	257	6	,	,	PUNCT
finefocus-2081	257	7	liu	liu	PROPN
finefocus-2081	257	8	dr	dr	PROPN
finefocus-2081	257	9	.	.	PROPN
finefocus-2081	257	10	2017	2017	NUM
finefocus-2081	257	11	.	.	PUNCT
finefocus-2081	258	1	crispr	crispr	NOUN
finefocus-2081	258	2	-	-	PUNCT
finefocus-2081	258	3	based	base	VERB
finefocus-2081	258	4	technologies	technology	NOUN
finefocus-2081	258	5	for	for	ADP
finefocus-2081	258	6	the	the	DET
finefocus-2081	258	7	manipulation	manipulation	NOUN
finefocus-2081	258	8	of	of	ADP
finefocus-2081	258	9	eukaryotic	eukaryotic	ADJ
finefocus-2081	258	10	genomes	genome	NOUN
finefocus-2081	258	11	.	.	PUNCT
finefocus-2081	259	1	cell	cell	NOUN
finefocus-2081	259	2	169:559	169:559	NUM
finefocus-2081	259	3	.	.	PUNCT
finefocus-2081	260	1	34	34	NUM
finefocus-2081	260	2	.	.	PUNCT
finefocus-2081	261	1	noman	noman	PROPN
finefocus-2081	261	2	a	a	PROPN
finefocus-2081	261	3	,	,	PUNCT
finefocus-2081	261	4	aqeel	aqeel	PROPN
finefocus-2081	261	5	m	m	PROPN
finefocus-2081	261	6	,	,	PUNCT
finefocus-2081	261	7	he	he	PRON
finefocus-2081	261	8	s.	s.	PROPN
finefocus-2081	261	9	2016	2016	NUM
finefocus-2081	261	10	.	.	PUNCT
finefocus-2081	262	1	crisprcas9	crisprcas9	NOUN
finefocus-2081	262	2	:	:	PUNCT
finefocus-2081	263	1	tool	tool	NOUN
finefocus-2081	263	2	for	for	ADP
finefocus-2081	263	3	qualitative	qualitative	ADJ
finefocus-2081	263	4	and	and	CCONJ
finefocus-2081	263	5	quantitative	quantitative	ADJ
finefocus-2081	263	6	plant	plant	NOUN
finefocus-2081	263	7	genome	genome	NOUN
finefocus-2081	263	8	editing	editing	NOUN
finefocus-2081	263	9	.	.	PUNCT
finefocus-2081	264	1	front	front	ADJ
finefocus-2081	264	2	plant	plant	NOUN
finefocus-2081	264	3	sci	sci	PROPN
finefocus-2081	264	4	7:1740	7:1740	NUM
finefocus-2081	264	5	.	.	PUNCT
finefocus-2081	265	1	35	35	NUM
finefocus-2081	265	2	.	.	PUNCT
finefocus-2081	265	3	square	square	PROPN
finefocus-2081	265	4	t	t	PROPN
finefocus-2081	265	5	,	,	PUNCT
finefocus-2081	265	6	romasek	romasek	PROPN
finefocus-2081	265	7	m	m	PROPN
finefocus-2081	265	8	,	,	PUNCT
finefocus-2081	265	9	jandzik	jandzik	PROPN
finefocus-2081	265	10	d	d	PROPN
finefocus-2081	265	11	,	,	PUNCT
finefocus-2081	265	12	cattell	cattell	PROPN
finefocus-2081	265	13	mv	mv	PROPN
finefocus-2081	265	14	,	,	PUNCT
finefocus-2081	265	15	klymkowsky	klymkowsky	PROPN
finefocus-2081	265	16	m	m	PROPN
finefocus-2081	265	17	,	,	PUNCT
finefocus-2081	265	18	medeiros	medeiros	PROPN
finefocus-2081	265	19	dm	dm	PROPN
finefocus-2081	265	20	.	.	PROPN
finefocus-2081	265	21	2015	2015	NUM
finefocus-2081	265	22	.	.	PUNCT
finefocus-2081	266	1	crispr	crispr	ADJ
finefocus-2081	266	2	/	/	SYM
finefocus-2081	266	3	cas9	cas9	NOUN
finefocus-2081	266	4	-	-	PUNCT
finefocus-2081	266	5	mediated	mediate	VERB
finefocus-2081	266	6	mutagenesis	mutagenesis	NOUN
finefocus-2081	266	7	in	in	ADP
finefocus-2081	266	8	the	the	DET
finefocus-2081	266	9	sea	sea	NOUN
finefocus-2081	266	10	lamprey	lamprey	PROPN
finefocus-2081	266	11	petromyzon	petromyzon	PROPN
finefocus-2081	266	12	marinus	marinus	PROPN
finefocus-2081	266	13	:	:	PUNCT
finefocus-2081	266	14	a	a	DET
finefocus-2081	266	15	powerful	powerful	ADJ
finefocus-2081	266	16	tool	tool	NOUN
finefocus-2081	266	17	for	for	ADP
finefocus-2081	266	18	understanding	understand	VERB
finefocus-2081	266	19	ancestral	ancestral	ADJ
finefocus-2081	266	20	gene	gene	NOUN
finefocus-2081	266	21	functions	function	NOUN
finefocus-2081	266	22	in	in	ADP
finefocus-2081	266	23	vertebrates	vertebrate	NOUN
finefocus-2081	266	24	.	.	PUNCT
finefocus-2081	267	1	development	development	NOUN
finefocus-2081	267	2	142:4180	142:4180	NUM
finefocus-2081	267	3	-	-	SYM
finefocus-2081	267	4	7	7	NUM
finefocus-2081	267	5	.	.	NUM
finefocus-2081	267	6	36	36	NUM
finefocus-2081	267	7	.	.	PUNCT
finefocus-2081	268	1	greenwood	greenwood	PROPN
finefocus-2081	268	2	v.	v.	PROPN
finefocus-2081	268	3	nova	nova	PROPN
finefocus-2081	268	4	nature	nature	PROPN
finefocus-2081	268	5	,	,	PUNCT
finefocus-2081	268	6	how	how	SCONJ
finefocus-2081	268	7	crispr	crispr	NOUN
finefocus-2081	268	8	is	be	AUX
finefocus-2081	268	9	spreading	spread	VERB
finefocus-2081	268	10	through	through	ADP
finefocus-2081	268	11	out	out	ADP
finefocus-2081	268	12	the	the	DET
finefocus-2081	268	13	animal	animal	NOUN
finefocus-2081	268	14	kingdom	kingdom	NOUN
finefocus-2081	268	15	.	.	PUNCT
finefocus-2081	269	1	2018	2018	NUM
finefocus-2081	269	2	37	37	NUM
finefocus-2081	269	3	.	.	PUNCT
finefocus-2081	270	1	spector	spector	PROPN
finefocus-2081	270	2	m.	m.	PROPN
finefocus-2081	270	3	2016	2016	NUM
finefocus-2081	270	4	.	.	PUNCT
finefocus-2081	271	1	national	national	PROPN
finefocus-2081	271	2	geographic	geographic	PROPN
finefocus-2081	271	3	the	the	DET
finefocus-2081	271	4	magazine	magazine	NOUN
finefocus-2081	271	5	,	,	PUNCT
finefocus-2081	271	6	how	how	SCONJ
finefocus-2081	271	7	the	the	DET
finefocus-2081	271	8	dna	dna	PROPN
finefocus-2081	271	9	revolution	revolution	PROPN
finefocus-2081	271	10	is	be	AUX
finefocus-2081	271	11	changing	change	VERB
finefocus-2081	271	12	us	we	PRON
finefocus-2081	271	13	.	.	PUNCT
finefocus-2081	272	1	2016	2016	NUM
finefocus-2081	272	2	38	38	NUM
finefocus-2081	272	3	.	.	PUNCT
finefocus-2081	273	1	hsu	hsu	PROPN
finefocus-2081	273	2	pd	pd	PROPN
finefocus-2081	273	3	,	,	PUNCT
finefocus-2081	273	4	lander	lander	PROPN
finefocus-2081	273	5	es	es	PROPN
finefocus-2081	273	6	,	,	PUNCT
finefocus-2081	273	7	zhang	zhang	PROPN
finefocus-2081	273	8	f.	f.	PROPN
finefocus-2081	273	9	2014	2014	NUM
finefocus-2081	273	10	.	.	PUNCT
finefocus-2081	274	1	development	development	NOUN
finefocus-2081	274	2	and	and	CCONJ
finefocus-2081	274	3	applications	application	NOUN
finefocus-2081	274	4	of	of	ADP
finefocus-2081	274	5	crispr	crispr	NOUN
finefocus-2081	274	6	-	-	PUNCT
finefocus-2081	274	7	cas9	cas9	NOUN
finefocus-2081	274	8	for	for	ADP
finefocus-2081	274	9	genome	genome	NOUN
finefocus-2081	274	10	engineering	engineering	NOUN
finefocus-2081	274	11	.	.	PUNCT
finefocus-2081	275	1	cell	cell	NOUN
finefocus-2081	275	2	157:1262	157:1262	PROPN
finefocus-2081	275	3	-	-	SYM
finefocus-2081	275	4	78	78	NUM
finefocus-2081	275	5	.	.	PUNCT
finefocus-2081	276	1	39	39	NUM
finefocus-2081	276	2	.	.	PUNCT
finefocus-2081	277	1	karkute	karkute	PROPN
finefocus-2081	277	2	sg	sg	PROPN
finefocus-2081	277	3	,	,	PUNCT
finefocus-2081	277	4	singh	singh	PROPN
finefocus-2081	277	5	ak	ak	PROPN
finefocus-2081	277	6	,	,	PUNCT
finefocus-2081	277	7	gupta	gupta	PROPN
finefocus-2081	277	8	op	op	NOUN
finefocus-2081	277	9	,	,	PUNCT
finefocus-2081	277	10	singh	singh	PROPN
finefocus-2081	277	11	pm	pm	NOUN
finefocus-2081	277	12	,	,	PUNCT
finefocus-2081	277	13	singh	singh	PROPN
finefocus-2081	277	14	b.	b.	PROPN
finefocus-2081	277	15	2017	2017	NUM
finefocus-2081	277	16	.	.	PUNCT
finefocus-2081	278	1	crispr	crispr	PROPN
finefocus-2081	278	2	/	/	SYM
finefocus-2081	278	3	cas9	cas9	NOUN
finefocus-2081	278	4	mediated	mediate	VERB
finefocus-2081	278	5	genome	genome	NOUN
finefocus-2081	278	6	engineering	engineering	NOUN
finefocus-2081	278	7	for	for	ADP
finefocus-2081	278	8	improvement	improvement	NOUN
finefocus-2081	278	9	of	of	ADP
finefocus-2081	278	10	horticultural	horticultural	ADJ
finefocus-2081	278	11	crops	crop	NOUN
finefocus-2081	278	12	.	.	PUNCT
finefocus-2081	279	1	front	front	ADJ
finefocus-2081	279	2	plant	plant	NOUN
finefocus-2081	279	3	sci	sci	PROPN
finefocus-2081	279	4	8:1635	8:1635	PROPN
finefocus-2081	279	5	.	.	PROPN
finefocus-2081	279	6	40	40	NUM
finefocus-2081	279	7	.	.	PUNCT
finefocus-2081	280	1	collins	collins	PROPN
finefocus-2081	280	2	jp	jp	PROPN
finefocus-2081	280	3	.	.	PROPN
finefocus-2081	280	4	2018	2018	NUM
finefocus-2081	280	5	.	.	PUNCT
finefocus-2081	281	1	gene	gene	NOUN
finefocus-2081	281	2	drives	drive	VERB
finefocus-2081	281	3	in	in	ADP
finefocus-2081	281	4	our	our	PRON
finefocus-2081	281	5	future	future	NOUN
finefocus-2081	281	6	:	:	PUNCT
finefocus-2081	281	7	challenges	challenge	NOUN
finefocus-2081	281	8	of	of	ADP
finefocus-2081	281	9	and	and	CCONJ
finefocus-2081	281	10	opportunities	opportunity	NOUN
finefocus-2081	281	11	for	for	ADP
finefocus-2081	281	12	using	use	VERB
finefocus-2081	281	13	a	a	DET
finefocus-2081	281	14	selfsustaining	selfsustaine	VERB
finefocus-2081	281	15	technology	technology	NOUN
finefocus-2081	281	16	in	in	ADP
finefocus-2081	281	17	pest	pest	NOUN
finefocus-2081	281	18	and	and	CCONJ
finefocus-2081	281	19	vector	vector	NOUN
finefocus-2081	281	20	management	management	NOUN
finefocus-2081	281	21	.	.	PUNCT
finefocus-2081	282	1	bmc	bmc	PROPN
finefocus-2081	282	2	proc	proc	PROPN
finefocus-2081	282	3	12:9	12:9	NUM
finefocus-2081	282	4	.	.	PROPN
finefocus-2081	282	5	41	41	NUM
finefocus-2081	282	6	.	.	PUNCT
finefocus-2081	283	1	leftwich	leftwich	PROPN
finefocus-2081	283	2	pt	pt	PROPN
finefocus-2081	283	3	,	,	PUNCT
finefocus-2081	283	4	edgington	edgington	PROPN
finefocus-2081	283	5	mp	mp	PROPN
finefocus-2081	283	6	,	,	PUNCT
finefocus-2081	283	7	harvey	harvey	PROPN
finefocus-2081	283	8	-	-	PUNCT
finefocus-2081	283	9	samuel	samuel	PROPN
finefocus-2081	283	10	t	t	PROPN
finefocus-2081	283	11	,	,	PUNCT
finefocus-2081	283	12	carabajal	carabajal	PROPN
finefocus-2081	283	13	paladino	paladino	PROPN
finefocus-2081	283	14	lz	lz	PROPN
finefocus-2081	283	15	,	,	PUNCT
finefocus-2081	283	16	norman	norman	PROPN
finefocus-2081	283	17	vc	vc	PROPN
finefocus-2081	283	18	,	,	PUNCT
finefocus-2081	283	19	alphey	alphey	PROPN
finefocus-2081	283	20	l.	l.	PROPN
finefocus-2081	283	21	2018	2018	NUM
finefocus-2081	283	22	.	.	PUNCT
finefocus-2081	284	1	recent	recent	ADJ
finefocus-2081	284	2	advances	advance	NOUN
finefocus-2081	284	3	in	in	ADP
finefocus-2081	284	4	threshold	threshold	NOUN
finefocus-2081	284	5	-	-	PUNCT
finefocus-2081	284	6	dependent	dependent	ADJ
finefocus-2081	284	7	gene	gene	NOUN
finefocus-2081	284	8	drives	drive	NOUN
finefocus-2081	284	9	for	for	ADP
finefocus-2081	284	10	mosquitoes	mosquito	NOUN
finefocus-2081	284	11	.	.	PUNCT
finefocus-2081	285	1	biochem	biochem	PROPN
finefocus-2081	285	2	soc	soc	PROPN
finefocus-2081	285	3	trans	trans	PROPN
finefocus-2081	285	4	.	.	PROPN
finefocus-2081	286	1	42	42	NUM
finefocus-2081	286	2	.	.	PUNCT
finefocus-2081	287	1	vesikansa	vesikansa	PROPN
finefocus-2081	287	2	a.	a.	NOUN
finefocus-2081	287	3	2018	2018	NUM
finefocus-2081	287	4	.	.	PUNCT
finefocus-2081	288	1	unraveling	unravel	VERB
finefocus-2081	288	2	of	of	ADP
finefocus-2081	288	3	central	central	ADJ
finefocus-2081	288	4	nervous	nervous	ADJ
finefocus-2081	288	5	system	system	NOUN
finefocus-2081	288	6	disease	disease	NOUN
finefocus-2081	288	7	mechanisms	mechanism	NOUN
finefocus-2081	288	8	using	use	VERB
finefocus-2081	288	9	crispr	crispr	ADJ
finefocus-2081	288	10	genome	genome	NOUN
finefocus-2081	288	11	manipulation	manipulation	NOUN
finefocus-2081	288	12	.	.	PUNCT
finefocus-2081	289	1	journal	journal	NOUN
finefocus-2081	289	2	of	of	ADP
finefocus-2081	289	3	central	central	ADJ
finefocus-2081	289	4	nervous	nervous	ADJ
finefocus-2081	289	5	system	system	NOUN
finefocus-2081	289	6	disease	disease	NOUN
finefocus-2081	289	7	10	10	NUM
finefocus-2081	289	8	.	.	PUNCT
finefocus-2081	289	9	43	43	NUM
finefocus-2081	289	10	.	.	PUNCT
finefocus-2081	290	1	kato	kato	PROPN
finefocus-2081	290	2	t	t	PROPN
finefocus-2081	290	3	,	,	PUNCT
finefocus-2081	290	4	takada	takada	PROPN
finefocus-2081	290	5	s.	s.	PROPN
finefocus-2081	290	6	2017	2017	NUM
finefocus-2081	290	7	.	.	PUNCT
finefocus-2081	291	1	in	in	ADP
finefocus-2081	291	2	vivo	vivo	NOUN
finefocus-2081	291	3	and	and	CCONJ
finefocus-2081	291	4	in	in	ADP
finefocus-2081	291	5	vitro	vitro	X
finefocus-2081	291	6	disease	disease	NOUN
finefocus-2081	291	7	modeling	modeling	NOUN
finefocus-2081	291	8	with	with	ADP
finefocus-2081	291	9	crispr	crispr	NOUN
finefocus-2081	291	10	/	/	SYM
finefocus-2081	291	11	cas9	cas9	NOUN
finefocus-2081	291	12	.	.	PUNCT
finefocus-2081	292	1	briefings	briefing	NOUN
finefocus-2081	292	2	in	in	ADP
finefocus-2081	292	3	functional	functional	ADJ
finefocus-2081	292	4	genomics	genomic	NOUN
finefocus-2081	292	5	16:13	16:13	NUM
finefocus-2081	292	6	-	-	SYM
finefocus-2081	292	7	24	24	NUM
finefocus-2081	292	8	.	.	PUNCT
finefocus-2081	292	9	44	44	NUM
finefocus-2081	292	10	.	.	PUNCT
finefocus-2081	293	1	dow	dow	PROPN
finefocus-2081	293	2	le	le	PROPN
finefocus-2081	293	3	.	.	PROPN
finefocus-2081	293	4	2015	2015	NUM
finefocus-2081	293	5	.	.	PUNCT
finefocus-2081	294	1	modeling	model	VERB
finefocus-2081	294	2	disease	disease	NOUN
finefocus-2081	294	3	in	in	ADP
finefocus-2081	294	4	vivo	vivo	NOUN
finefocus-2081	294	5	with	with	ADP
finefocus-2081	294	6	crispr	crispr	NOUN
finefocus-2081	294	7	/	/	SYM
finefocus-2081	294	8	cas9	cas9	NOUN
finefocus-2081	294	9	.	.	PUNCT
finefocus-2081	295	1	trends	trend	NOUN
finefocus-2081	295	2	in	in	ADP
finefocus-2081	295	3	molecular	molecular	ADJ
finefocus-2081	295	4	medicine	medicine	NOUN
finefocus-2081	295	5	21:609621	21:609621	NUM
finefocus-2081	295	6	.	.	PROPN
finefocus-2081	295	7	45	45	NUM
finefocus-2081	295	8	.	.	PUNCT
finefocus-2081	295	9	chow	chow	PROPN
finefocus-2081	295	10	rd	rd	PROPN
finefocus-2081	295	11	,	,	PUNCT
finefocus-2081	295	12	chen	chen	PROPN
finefocus-2081	295	13	s.	s.	PROPN
finefocus-2081	295	14	2018	2018	NUM
finefocus-2081	295	15	.	.	PUNCT
finefocus-2081	296	1	cancer	cancer	NOUN
finefocus-2081	296	2	crispr	crispr	ADJ
finefocus-2081	296	3	screens	screen	NOUN
finefocus-2081	296	4	in	in	ADP
finefocus-2081	296	5	vivo	vivo	NOUN
finefocus-2081	296	6	.	.	PUNCT
finefocus-2081	297	1	trends	trend	NOUN
finefocus-2081	297	2	cancer	cancer	NOUN
finefocus-2081	297	3	4:349	4:349	PROPN
finefocus-2081	297	4	-	-	SYM
finefocus-2081	297	5	358	358	NUM
finefocus-2081	297	6	.	.	PUNCT
finefocus-2081	298	1	46	46	NUM
finefocus-2081	298	2	.	.	PUNCT
finefocus-2081	299	1	beneke	beneke	PROPN
finefocus-2081	299	2	t	t	PROPN
finefocus-2081	299	3	,	,	PUNCT
finefocus-2081	299	4	madden	madden	PROPN
finefocus-2081	299	5	r	r	NOUN
finefocus-2081	299	6	,	,	PUNCT
finefocus-2081	299	7	makin	makin	NOUN
finefocus-2081	299	8	l	l	PROPN
finefocus-2081	299	9	,	,	PUNCT
finefocus-2081	299	10	valli	valli	PROPN
finefocus-2081	299	11	j	j	PROPN
finefocus-2081	299	12	,	,	PUNCT
finefocus-2081	299	13	sunter	sunter	PROPN
finefocus-2081	299	14	j	j	PROPN
finefocus-2081	299	15	,	,	PUNCT
finefocus-2081	299	16	gluenz	gluenz	PROPN
finefocus-2081	299	17	e.	e.	PROPN
finefocus-2081	299	18	2017	2017	NUM
finefocus-2081	299	19	.	.	PUNCT
finefocus-2081	300	1	a	a	DET
finefocus-2081	300	2	crispr	crispr	ADJ
finefocus-2081	300	3	cas9	cas9	NOUN
finefocus-2081	300	4	high	high	ADJ
finefocus-2081	300	5	-	-	PUNCT
finefocus-2081	300	6	throughput	throughput	NOUN
finefocus-2081	300	7	genome	genome	NOUN
finefocus-2081	300	8	editing	edit	VERB
finefocus-2081	300	9	toolkit	toolkit	NOUN
finefocus-2081	300	10	for	for	ADP
finefocus-2081	300	11	kinetoplastids	kinetoplastid	NOUN
finefocus-2081	300	12	.	.	PUNCT
finefocus-2081	301	1	r	r	NOUN
finefocus-2081	301	2	soc	soc	NOUN
finefocus-2081	301	3	open	open	VERB
finefocus-2081	301	4	sci	sci	PROPN
finefocus-2081	301	5	4:170095	4:170095	NUM
finefocus-2081	301	6	.	.	PUNCT
finefocus-2081	302	1	47	47	NUM
finefocus-2081	302	2	.	.	PUNCT
finefocus-2081	303	1	soares	soares	PROPN
finefocus-2081	303	2	medeiros	medeiros	PROPN
finefocus-2081	303	3	lc	lc	PROPN
finefocus-2081	303	4	,	,	PUNCT
finefocus-2081	303	5	south	south	PROPN
finefocus-2081	303	6	l	l	PROPN
finefocus-2081	303	7	,	,	PUNCT
finefocus-2081	303	8	peng	peng	PROPN
finefocus-2081	303	9	d	d	PROPN
finefocus-2081	303	10	,	,	PUNCT
finefocus-2081	303	11	bustamante	bustamante	PROPN
finefocus-2081	303	12	jm	jm	PROPN
finefocus-2081	303	13	,	,	PUNCT
finefocus-2081	303	14	wang	wang	PROPN
finefocus-2081	303	15	w	w	PROPN
finefocus-2081	303	16	,	,	PUNCT
finefocus-2081	303	17	bunkofske	bunkofske	PROPN
finefocus-2081	303	18	m	m	PROPN
finefocus-2081	303	19	,	,	PUNCT
finefocus-2081	303	20	perumal	perumal	NOUN
finefocus-2081	303	21	n	n	CCONJ
finefocus-2081	303	22	,	,	PUNCT
finefocus-2081	303	23	sanchez	sanchez	NOUN
finefocus-2081	303	24	-	-	PUNCT
finefocus-2081	303	25	valdez	valdez	PROPN
finefocus-2081	303	26	f	f	PROPN
finefocus-2081	303	27	,	,	PUNCT
finefocus-2081	303	28	tarleton	tarleton	PROPN
finefocus-2081	303	29	rl	rl	PROPN
finefocus-2081	303	30	.	.	PROPN
finefocus-2081	303	31	2017	2017	NUM
finefocus-2081	303	32	.	.	PUNCT
finefocus-2081	304	1	rapid	rapid	ADJ
finefocus-2081	304	2	,	,	PUNCT
finefocus-2081	304	3	selection	selection	NOUN
finefocus-2081	304	4	-	-	PUNCT
finefocus-2081	304	5	free	free	ADJ
finefocus-2081	304	6	,	,	PUNCT
finefocus-2081	304	7	high	high	ADJ
finefocus-2081	304	8	-	-	PUNCT
finefocus-2081	304	9	efficiency	efficiency	NOUN
finefocus-2081	304	10	genome	genome	NOUN
finefocus-2081	304	11	editing	editing	NOUN
finefocus-2081	304	12	in	in	ADP
finefocus-2081	304	13	protozoan	protozoan	NOUN
finefocus-2081	304	14	parasites	parasite	NOUN
finefocus-2081	304	15	using	use	VERB
finefocus-2081	304	16	crispr	crispr	ADJ
finefocus-2081	304	17	-	-	PUNCT
finefocus-2081	304	18	cas9	cas9	NOUN
finefocus-2081	304	19	ribonucleoproteins	ribonucleoprotein	NOUN
finefocus-2081	304	20	.	.	PUNCT
finefocus-2081	305	1	mbio	mbio	PROPN
finefocus-2081	305	2	8	8	NUM
finefocus-2081	305	3	.	.	NOUN
finefocus-2081	305	4	48	48	NUM
finefocus-2081	305	5	.	.	PUNCT
finefocus-2081	306	1	xiong	xiong	PROPN
finefocus-2081	307	1	x	x	PROPN
finefocus-2081	307	2	,	,	PUNCT
finefocus-2081	307	3	chen	chen	PROPN
finefocus-2081	307	4	m	m	PROPN
finefocus-2081	307	5	,	,	PUNCT
finefocus-2081	307	6	lim	lim	PROPN
finefocus-2081	307	7	wa	wa	PROPN
finefocus-2081	307	8	,	,	PUNCT
finefocus-2081	307	9	zhao	zhao	PROPN
finefocus-2081	307	10	d	d	PROPN
finefocus-2081	307	11	,	,	PUNCT
finefocus-2081	307	12	qi	qi	PROPN
finefocus-2081	307	13	ls	ls	PROPN
finefocus-2081	307	14	.	.	PROPN
finefocus-2081	307	15	2016	2016	NUM
finefocus-2081	307	16	.	.	PUNCT
finefocus-2081	308	1	crispr	crispr	PROPN
finefocus-2081	308	2	/	/	SYM
finefocus-2081	308	3	cas9	cas9	NOUN
finefocus-2081	308	4	for	for	ADP
finefocus-2081	308	5	human	human	ADJ
finefocus-2081	308	6	genome	genome	NOUN
finefocus-2081	308	7	engineering	engineering	NOUN
finefocus-2081	308	8	and	and	CCONJ
finefocus-2081	308	9	disease	disease	NOUN
finefocus-2081	308	10	research	research	NOUN
finefocus-2081	308	11	.	.	PUNCT
finefocus-2081	309	1	annu	annu	PROPN
finefocus-2081	309	2	rev	rev	VERB
finefocus-2081	309	3	genomics	genomics	PROPN
finefocus-2081	309	4	hum	hum	PROPN
finefocus-2081	309	5	genet	genet	PROPN
finefocus-2081	309	6	17:131	17:131	PROPN
finefocus-2081	309	7	-	-	SYM
finefocus-2081	309	8	54	54	NUM
finefocus-2081	309	9	.	.	PUNCT
finefocus-2081	310	1	49	49	NUM
finefocus-2081	310	2	.	.	PUNCT
finefocus-2081	311	1	vassena	vassena	PROPN
finefocus-2081	311	2	r	r	PROPN
finefocus-2081	311	3	,	,	PUNCT
finefocus-2081	311	4	heindryckx	heindryckx	PROPN
finefocus-2081	311	5	b	b	PROPN
finefocus-2081	311	6	,	,	PUNCT
finefocus-2081	311	7	peco	peco	PROPN
finefocus-2081	311	8	r	r	PROPN
finefocus-2081	311	9	,	,	PUNCT
finefocus-2081	311	10	pennings	penning	NOUN
finefocus-2081	311	11	g	g	PROPN
finefocus-2081	311	12	,	,	PUNCT
finefocus-2081	311	13	raya	raya	PROPN
finefocus-2081	311	14	a	a	X
finefocus-2081	311	15	,	,	PUNCT
finefocus-2081	311	16	sermon	sermon	NOUN
finefocus-2081	311	17	k	k	PROPN
finefocus-2081	311	18	,	,	PUNCT
finefocus-2081	311	19	veiga	veiga	ADJ
finefocus-2081	311	20	a.	a.	NOUN
finefocus-2081	311	21	2016	2016	NUM
finefocus-2081	311	22	.	.	PUNCT
finefocus-2081	312	1	genome	genome	NOUN
finefocus-2081	312	2	engineering	engineering	NOUN
finefocus-2081	312	3	through	through	ADP
finefocus-2081	312	4	crispr	crispr	ADJ
finefocus-2081	312	5	/	/	SYM
finefocus-2081	312	6	cas9	cas9	NOUN
finefocus-2081	312	7	technology	technology	NOUN
finefocus-2081	312	8	in	in	ADP
finefocus-2081	312	9	the	the	DET
finefocus-2081	312	10	human	human	PROPN
finefocus-2081	312	11	germline	germline	NOUN
finefocus-2081	312	12	and	and	CCONJ
finefocus-2081	312	13	pluripotent	pluripotent	ADJ
finefocus-2081	312	14	stem	stem	NOUN
finefocus-2081	312	15	cells	cell	NOUN
finefocus-2081	312	16	.	.	PUNCT
finefocus-2081	313	1	hum	hum	PROPN
finefocus-2081	313	2	reprod	reprod	PROPN
finefocus-2081	313	3	update	update	VERB
finefocus-2081	313	4	22:411	22:411	NUM
finefocus-2081	313	5	-	-	SYM
finefocus-2081	313	6	9	9	NUM
finefocus-2081	313	7	.	.	NOUN
finefocus-2081	313	8	50	50	NUM
finefocus-2081	313	9	.	.	PUNCT
finefocus-2081	314	1	dahlberg	dahlberg	PROPN
finefocus-2081	314	2	lgc	lgc	PROPN
finefocus-2081	314	3	,	,	PUNCT
finefocus-2081	314	4	a.m.	a.m.	NOUN
finefocus-2081	314	5	2018	2018	NUM
finefocus-2081	314	6	.	.	PUNCT
finefocus-2081	315	1	crispr	crispr	ADJ
finefocus-2081	315	2	-	-	PUNCT
finefocus-2081	315	3	cas	cas	NOUN
finefocus-2081	315	4	technology	technology	NOUN
finefocus-2081	315	5	in	in	ADP
finefocus-2081	315	6	and	and	CCONJ
finefocus-2081	315	7	out	out	ADP
finefocus-2081	315	8	of	of	ADP
finefocus-2081	315	9	the	the	DET
finefocus-2081	315	10	classroom	classroom	NOUN
finefocus-2081	315	11	.	.	PUNCT
finefocus-2081	316	1	crispr	crispr	ADJ
finefocus-2081	316	2	.	.	PUNCT
finefocus-2081	317	1	51	51	NUM
finefocus-2081	317	2	.	.	PUNCT
finefocus-2081	318	1	jones	jones	PROPN
finefocus-2081	318	2	t	t	PROPN
finefocus-2081	318	3	,	,	PUNCT
finefocus-2081	318	4	federspiel	federspiel	VERB
finefocus-2081	318	5	na	na	ADP
finefocus-2081	318	6	,	,	PUNCT
finefocus-2081	318	7	chibana	chibana	PROPN
finefocus-2081	318	8	h	h	PROPN
finefocus-2081	318	9	,	,	PUNCT
finefocus-2081	318	10	dungan	dungan	PROPN
finefocus-2081	318	11	j	j	PROPN
finefocus-2081	318	12	,	,	PUNCT
finefocus-2081	318	13	kalman	kalman	PROPN
finefocus-2081	318	14	s	s	PROPN
finefocus-2081	318	15	,	,	PUNCT
finefocus-2081	318	16	magee	magee	PROPN
finefocus-2081	318	17	bb	bb	PROPN
finefocus-2081	318	18	,	,	PUNCT
finefocus-2081	318	19	newport	newport	PROPN
finefocus-2081	318	20	g	g	PROPN
finefocus-2081	318	21	,	,	PUNCT
finefocus-2081	318	22	thorstenson	thorstenson	NOUN
finefocus-2081	318	23	yr	yr	NOUN
finefocus-2081	318	24	,	,	PUNCT
finefocus-2081	318	25	agabian	agabian	PROPN
finefocus-2081	318	26	n	n	CCONJ
finefocus-2081	318	27	,	,	PUNCT
finefocus-2081	318	28	magee	magee	PROPN
finefocus-2081	318	29	pt	pt	PROPN
finefocus-2081	318	30	,	,	PUNCT
finefocus-2081	318	31	davis	davis	PROPN
finefocus-2081	318	32	rw	rw	PROPN
finefocus-2081	318	33	,	,	PUNCT
finefocus-2081	318	34	scherer	scherer	PROPN
finefocus-2081	318	35	s.	s.	PROPN
finefocus-2081	318	36	2004	2004	PROPN
finefocus-2081	318	37	.	.	PUNCT
finefocus-2081	319	1	crispr	crispr	ADJ
finefocus-2081	319	2	•	•	ADV
finefocus-2081	319	3	33	33	NUM
finefocus-2081	319	4	the	the	DET
finefocus-2081	319	5	diploid	diploid	ADJ
finefocus-2081	319	6	genome	genome	NOUN
finefocus-2081	319	7	sequence	sequence	NOUN
finefocus-2081	319	8	of	of	ADP
finefocus-2081	319	9	candida	candida	NOUN
finefocus-2081	319	10	albicans	albican	NOUN
finefocus-2081	319	11	.	.	PUNCT
finefocus-2081	320	1	proc	proc	PROPN
finefocus-2081	320	2	natl	natl	PROPN
finefocus-2081	320	3	acad	acad	PROPN
finefocus-2081	320	4	sci	sci	PROPN
finefocus-2081	320	5	u	u	PROPN
finefocus-2081	320	6	s	s	PROPN
finefocus-2081	320	7	a	a	DET
finefocus-2081	320	8	101:7329	101:7329	NUM
finefocus-2081	320	9	-	-	SYM
finefocus-2081	320	10	34	34	NUM
finefocus-2081	320	11	.	.	PROPN
finefocus-2081	320	12	52	52	NUM
finefocus-2081	320	13	.	.	PUNCT
finefocus-2081	321	1	morschhauser	morschhauser	PROPN
finefocus-2081	321	2	j	j	PROPN
finefocus-2081	321	3	,	,	PUNCT
finefocus-2081	321	4	michel	michel	PROPN
finefocus-2081	321	5	s	s	PROPN
finefocus-2081	321	6	,	,	PUNCT
finefocus-2081	321	7	staib	staib	ADJ
finefocus-2081	321	8	p.	p.	NOUN
finefocus-2081	321	9	1999	1999	NUM
finefocus-2081	321	10	.	.	PUNCT
finefocus-2081	322	1	sequential	sequential	ADJ
finefocus-2081	322	2	gene	gene	NOUN
finefocus-2081	322	3	disruption	disruption	NOUN
finefocus-2081	322	4	in	in	ADP
finefocus-2081	322	5	candida	candida	PROPN
finefocus-2081	322	6	albicans	albican	NOUN
finefocus-2081	322	7	by	by	ADP
finefocus-2081	322	8	flp	flp	PROPN
finefocus-2081	322	9	-	-	PUNCT
finefocus-2081	322	10	mediated	mediate	VERB
finefocus-2081	322	11	site	site	NOUN
finefocus-2081	322	12	-	-	PUNCT
finefocus-2081	322	13	specific	specific	ADJ
finefocus-2081	322	14	recombination	recombination	NOUN
finefocus-2081	322	15	.	.	PUNCT
finefocus-2081	323	1	mol	mol	ADP
finefocus-2081	323	2	microbiol	microbiol	PROPN
finefocus-2081	323	3	32:547	32:547	NUM
finefocus-2081	323	4	-	-	SYM
finefocus-2081	323	5	56	56	NUM
finefocus-2081	323	6	.	.	PUNCT
finefocus-2081	323	7	53	53	NUM
finefocus-2081	323	8	.	.	PUNCT
finefocus-2081	324	1	evans	evans	PROPN
finefocus-2081	324	2	ba	ba	PROPN
finefocus-2081	324	3	,	,	PUNCT
finefocus-2081	324	4	smith	smith	PROPN
finefocus-2081	324	5	ol	ol	PROPN
finefocus-2081	324	6	,	,	PUNCT
finefocus-2081	324	7	pickerill	pickerill	NOUN
finefocus-2081	324	8	es	es	PROPN
finefocus-2081	324	9	,	,	PUNCT
finefocus-2081	324	10	york	york	PROPN
finefocus-2081	324	11	mk	mk	PROPN
finefocus-2081	324	12	,	,	PUNCT
finefocus-2081	324	13	buenconsejo	buenconsejo	PROPN
finefocus-2081	324	14	kjp	kjp	PROPN
finefocus-2081	324	15	,	,	PUNCT
finefocus-2081	324	16	chambers	chambers	PROPN
finefocus-2081	324	17	ae	ae	PROPN
finefocus-2081	324	18	,	,	PUNCT
finefocus-2081	324	19	bernstein	bernstein	PROPN
finefocus-2081	324	20	da	da	PROPN
finefocus-2081	324	21	.	.	PROPN
finefocus-2081	324	22	2018	2018	NUM
finefocus-2081	324	23	.	.	PUNCT
finefocus-2081	325	1	restriction	restriction	NOUN
finefocus-2081	325	2	digest	digest	NOUN
finefocus-2081	325	3	screening	screening	NOUN
finefocus-2081	325	4	facilitates	facilitate	VERB
finefocus-2081	325	5	efficient	efficient	ADJ
finefocus-2081	325	6	detection	detection	NOUN
finefocus-2081	325	7	of	of	ADP
finefocus-2081	325	8	site	site	NOUN
finefocus-2081	325	9	-	-	PUNCT
finefocus-2081	325	10	directed	direct	VERB
finefocus-2081	325	11	mutations	mutation	NOUN
finefocus-2081	325	12	introduced	introduce	VERB
finefocus-2081	325	13	by	by	ADP
finefocus-2081	325	14	crispr	crispr	PROPN
finefocus-2081	325	15	in	in	ADP
finefocus-2081	325	16	c.	c.	PROPN
finefocus-2081	325	17	albicans	albican	NOUN
finefocus-2081	325	18	ume6	ume6	PROPN
finefocus-2081	325	19	.	.	PUNCT
finefocus-2081	326	1	peerj	peerj	PROPN
finefocus-2081	326	2	6	6	NUM
finefocus-2081	326	3	:	:	PUNCT
finefocus-2081	326	4	e4920	e4920	NOUN
finefocus-2081	326	5	.	.	PROPN
finefocus-2081	326	6	54	54	NUM
finefocus-2081	326	7	.	.	PUNCT
finefocus-2081	327	1	anonymous	anonymous	ADJ
finefocus-2081	327	2	.	.	PUNCT
finefocus-2081	327	3	1991	1991	NUM
finefocus-2081	327	4	.	.	PUNCT
finefocus-2081	328	1	guide	guide	VERB
finefocus-2081	328	2	to	to	ADP
finefocus-2081	328	3	yeast	yeast	NOUN
finefocus-2081	328	4	genetics	genetic	NOUN
finefocus-2081	328	5	and	and	CCONJ
finefocus-2081	328	6	molecular	molecular	ADJ
finefocus-2081	328	7	biology	biology	NOUN
finefocus-2081	328	8	.	.	PUNCT
finefocus-2081	329	1	methods	method	NOUN
finefocus-2081	329	2	enzymol	enzymol	PROPN
finefocus-2081	329	3	194:1	194:1	NUM
finefocus-2081	329	4	-	-	PUNCT
finefocus-2081	329	5	863	863	NUM
finefocus-2081	329	6	.	.	PUNCT
finefocus-2081	330	1	55	55	NUM
finefocus-2081	330	2	.	.	PUNCT
finefocus-2081	331	1	dolan	dolan	PROPN
finefocus-2081	331	2	el	el	PROPN
finefocus-2081	331	3	.	.	PROPN
finefocus-2081	331	4	2017	2017	NUM
finefocus-2081	331	5	.	.	PUNCT
finefocus-2081	332	1	course	course	NOUN
finefocus-2081	332	2	-	-	PUNCT
finefocus-2081	332	3	based	base	VERB
finefocus-2081	332	4	undergraduate	undergraduate	NOUN
finefocus-2081	332	5	research	research	NOUN
finefocus-2081	332	6	experiences	experience	NOUN
finefocus-2081	332	7	:	:	PUNCT
finefocus-2081	332	8	current	current	ADJ
finefocus-2081	332	9	knowledge	knowledge	NOUN
finefocus-2081	332	10	and	and	CCONJ
finefocus-2081	332	11	future	future	ADJ
finefocus-2081	332	12	directions	direction	NOUN
finefocus-2081	332	13	.	.	PUNCT
finefocus-2081	333	1	nsf	nsf	NOUN
finefocus-2081	333	2	.	.	PROPN
finefocus-2081	333	3	56	56	NUM
finefocus-2081	333	4	.	.	PUNCT
finefocus-2081	333	5	challa	challa	PROPN
finefocus-2081	333	6	ak	ak	PROPN
finefocus-2081	333	7	,	,	PUNCT
finefocus-2081	333	8	bhatt	bhatt	PROPN
finefocus-2081	333	9	jm	jm	PROPN
finefocus-2081	333	10	.	.	PROPN
finefocus-2081	333	11	2015	2015	NUM
finefocus-2081	333	12	.	.	PUNCT
finefocus-2081	334	1	first	first	ADJ
finefocus-2081	334	2	year	year	NOUN
finefocus-2081	334	3	coursebased	coursebase	VERB
finefocus-2081	334	4	undergraduate	undergraduate	NOUN
finefocus-2081	334	5	research	research	NOUN
finefocus-2081	334	6	experience	experience	NOUN
finefocus-2081	334	7	(	(	PUNCT
finefocus-2081	334	8	cure	cure	NOUN
finefocus-2081	334	9	)	)	PUNCT
finefocus-2081	334	10	using	use	VERB
finefocus-2081	334	11	the	the	DET
finefocus-2081	334	12	crispr	crispr	ADJ
finefocus-2081	334	13	-	-	PUNCT
finefocus-2081	334	14	cas9	cas9	NOUN
finefocus-2081	334	15	genome	genome	NOUN
finefocus-2081	334	16	engineering	engineering	NOUN
finefocus-2081	334	17	technology	technology	NOUN
finefocus-2081	334	18	in	in	ADP
finefocus-2081	334	19	zebrafish	zebrafish	ADJ
finefocus-2081	334	20	.	.	PUNCT
finefocus-2081	335	1	molecular	molecular	ADJ
finefocus-2081	335	2	biology	biology	NOUN
finefocus-2081	335	3	of	of	ADP
finefocus-2081	335	4	the	the	DET
finefocus-2081	335	5	cell	cell	NOUN
finefocus-2081	335	6	26	26	NUM
finefocus-2081	335	7	.	.	PUNCT
finefocus-2081	336	1	57	57	NUM
finefocus-2081	336	2	.	.	PUNCT
finefocus-2081	336	3	adame	adame	PROPN
finefocus-2081	336	4	v	v	NOUN
finefocus-2081	336	5	,	,	PUNCT
finefocus-2081	336	6	chapapas	chapapas	PROPN
finefocus-2081	336	7	h	h	NOUN
finefocus-2081	336	8	,	,	PUNCT
finefocus-2081	336	9	cisneros	cisneros	PROPN
finefocus-2081	336	10	m	m	PROPN
finefocus-2081	336	11	,	,	PUNCT
finefocus-2081	336	12	deaton	deaton	PROPN
finefocus-2081	336	13	c	c	PROPN
finefocus-2081	336	14	,	,	PUNCT
finefocus-2081	336	15	deichmann	deichmann	PROPN
finefocus-2081	336	16	s	s	PROPN
finefocus-2081	336	17	,	,	PUNCT
finefocus-2081	336	18	gadek	gadek	NOUN
finefocus-2081	336	19	c	c	PROPN
finefocus-2081	336	20	,	,	PUNCT
finefocus-2081	336	21	lovato	lovato	PROPN
finefocus-2081	336	22	tl	tl	PROPN
finefocus-2081	336	23	,	,	PUNCT
finefocus-2081	336	24	chechenova	chechenova	PROPN
finefocus-2081	336	25	mb	mb	ADP
finefocus-2081	336	26	,	,	PUNCT
finefocus-2081	336	27	guerin	guerin	PROPN
finefocus-2081	336	28	p	p	PROPN
finefocus-2081	336	29	,	,	PUNCT
finefocus-2081	336	30	cripps	cripps	PROPN
finefocus-2081	336	31	rm	rm	PROPN
finefocus-2081	336	32	.	.	PROPN
finefocus-2081	336	33	2016	2016	NUM
finefocus-2081	336	34	.	.	PUNCT
finefocus-2081	337	1	an	an	DET
finefocus-2081	337	2	undergraduate	undergraduate	ADJ
finefocus-2081	337	3	laboratory	laboratory	NOUN
finefocus-2081	337	4	class	class	NOUN
finefocus-2081	337	5	using	use	VERB
finefocus-2081	337	6	crispr	crispr	ADJ
finefocus-2081	337	7	/	/	SYM
finefocus-2081	337	8	cas9	cas9	NOUN
finefocus-2081	337	9	technology	technology	NOUN
finefocus-2081	337	10	to	to	PART
finefocus-2081	337	11	mutate	mutate	VERB
finefocus-2081	337	12	drosophila	drosophila	NOUN
finefocus-2081	337	13	genes	gene	NOUN
finefocus-2081	337	14	.	.	PUNCT
finefocus-2081	338	1	biochemistry	biochemistry	NOUN
finefocus-2081	338	2	and	and	CCONJ
finefocus-2081	338	3	molecular	molecular	ADJ
finefocus-2081	338	4	biology	biology	NOUN
finefocus-2081	338	5	education	education	NOUN
finefocus-2081	338	6	44:263	44:263	NUM
finefocus-2081	338	7	-	-	SYM
finefocus-2081	338	8	275	275	NUM
finefocus-2081	338	9	.	.	PUNCT
finefocus-2081	339	1	58	58	NUM
finefocus-2081	339	2	.	.	PUNCT
finefocus-2081	340	1	anderson	anderson	PROPN
finefocus-2081	340	2	hje	hje	PROPN
finefocus-2081	340	3	.	.	PUNCT
finefocus-2081	341	1	2017	2017	NUM
finefocus-2081	341	2	.	.	PUNCT
finefocus-2081	342	1	crispr	crispr	ADJ
finefocus-2081	342	2	in	in	ADP
finefocus-2081	342	3	the	the	DET
finefocus-2081	342	4	undergraduate	undergraduate	ADJ
finefocus-2081	342	5	classroom	classroom	NOUN
finefocus-2081	342	6	:	:	PUNCT
finefocus-2081	342	7	a	a	DET
finefocus-2081	342	8	cure	cure	NOUN
finefocus-2081	342	9	.	.	PUNCT
finefocus-2081	343	1	faseb	faseb	PROPN
finefocus-2081	343	2	journal	journal	PROPN
finefocus-2081	343	3	31	31	NUM
finefocus-2081	343	4	.	.	PUNCT
finefocus-2081	344	1	59	59	NUM
finefocus-2081	344	2	.	.	PUNCT
finefocus-2081	345	1	hynes	hynes	PROPN
finefocus-2081	345	2	ap	ap	PROPN
finefocus-2081	345	3	,	,	PUNCT
finefocus-2081	345	4	lemay	lemay	PROPN
finefocus-2081	345	5	ml	ml	PROPN
finefocus-2081	345	6	,	,	PUNCT
finefocus-2081	345	7	trudel	trudel	PROPN
finefocus-2081	345	8	l	l	NOUN
finefocus-2081	345	9	,	,	PUNCT
finefocus-2081	345	10	deveau	deveau	PROPN
finefocus-2081	345	11	h	h	PROPN
finefocus-2081	345	12	,	,	PUNCT
finefocus-2081	345	13	frenette	frenette	PROPN
finefocus-2081	345	14	m	m	PROPN
finefocus-2081	345	15	,	,	PUNCT
finefocus-2081	345	16	tremblay	tremblay	VERB
finefocus-2081	345	17	dm	dm	PROPN
finefocus-2081	345	18	,	,	PUNCT
finefocus-2081	345	19	moineau	moineau	ADJ
finefocus-2081	345	20	s.	s.	PROPN
finefocus-2081	345	21	2017	2017	NUM
finefocus-2081	345	22	.	.	PUNCT
finefocus-2081	346	1	detecting	detect	VERB
finefocus-2081	346	2	natural	natural	ADJ
finefocus-2081	346	3	adaptation	adaptation	NOUN
finefocus-2081	346	4	of	of	ADP
finefocus-2081	346	5	the	the	DET
finefocus-2081	346	6	streptococcus	streptococcus	NOUN
finefocus-2081	346	7	thermophilus	thermophilus	NOUN
finefocus-2081	346	8	crispr	crispr	NOUN
finefocus-2081	346	9	-	-	PUNCT
finefocus-2081	346	10	cas	cas	NOUN
finefocus-2081	346	11	systems	system	NOUN
finefocus-2081	346	12	in	in	ADP
finefocus-2081	346	13	research	research	NOUN
finefocus-2081	346	14	and	and	CCONJ
finefocus-2081	346	15	classroom	classroom	NOUN
finefocus-2081	346	16	settings	setting	NOUN
finefocus-2081	346	17	.	.	PUNCT
finefocus-2081	347	1	nature	nature	NOUN
finefocus-2081	347	2	protocols	protocol	NOUN
finefocus-2081	347	3	12:547	12:547	NUM
finefocus-2081	347	4	-	-	SYM
finefocus-2081	347	5	565	565	NUM
finefocus-2081	347	6	.	.	PUNCT
finefocus-2081	347	7	60	60	NUM
finefocus-2081	347	8	.	.	PUNCT
finefocus-2081	348	1	militello	militello	PROPN
finefocus-2081	348	2	kt	kt	PROPN
finefocus-2081	348	3	,	,	PUNCT
finefocus-2081	348	4	lazatin	lazatin	PROPN
finefocus-2081	348	5	jc	jc	PROPN
finefocus-2081	348	6	.	.	PROPN
finefocus-2081	348	7	2017	2017	NUM
finefocus-2081	348	8	.	.	PUNCT
finefocus-2081	349	1	discovery	discovery	NOUN
finefocus-2081	349	2	of	of	ADP
finefocus-2081	349	3	escherichia	escherichia	NOUN
finefocus-2081	349	4	coli	coli	NOUN
finefocus-2081	349	5	crispr	crispr	ADJ
finefocus-2081	349	6	sequences	sequence	NOUN
finefocus-2081	349	7	in	in	ADP
finefocus-2081	349	8	an	an	DET
finefocus-2081	349	9	undergraduate	undergraduate	ADJ
finefocus-2081	349	10	laboratory	laboratory	NOUN
finefocus-2081	349	11	.	.	PUNCT
finefocus-2081	350	1	biochem	biochem	PROPN
finefocus-2081	350	2	mol	mol	ADP
finefocus-2081	350	3	biol	biol	PROPN
finefocus-2081	350	4	educ	educ	VERB
finefocus-2081	350	5	45:262	45:262	PROPN
finefocus-2081	350	6	-	-	PUNCT
finefocus-2081	350	7	269	269	NUM
finefocus-2081	350	8	.	.	NOUN
finefocus-2081	350	9	61	61	NUM
finefocus-2081	350	10	.	.	PUNCT
finefocus-2081	351	1	shinwari	shinwari	PROPN
finefocus-2081	351	2	zk	zk	PROPN
finefocus-2081	351	3	,	,	PUNCT
finefocus-2081	351	4	tanveer	tanveer	PROPN
finefocus-2081	351	5	f	f	PROPN
finefocus-2081	351	6	,	,	PUNCT
finefocus-2081	351	7	khalil	khalil	PROPN
finefocus-2081	351	8	at	at	ADP
finefocus-2081	351	9	.	.	PROPN
finefocus-2081	351	10	2018	2018	NUM
finefocus-2081	351	11	.	.	PUNCT
finefocus-2081	352	1	ethical	ethical	ADJ
finefocus-2081	352	2	issues	issue	NOUN
finefocus-2081	352	3	regarding	regard	VERB
finefocus-2081	352	4	crispr	crispr	ADJ
finefocus-2081	352	5	mediated	mediate	VERB
finefocus-2081	352	6	genome	genome	NOUN
finefocus-2081	352	7	editing	editing	NOUN
finefocus-2081	352	8	.	.	PUNCT
finefocus-2081	353	1	curr	curr	PROPN
finefocus-2081	353	2	issues	issue	NOUN
finefocus-2081	353	3	mol	mol	ADP
finefocus-2081	353	4	biol	biol	PROPN
finefocus-2081	353	5	26:103	26:103	PROPN
finefocus-2081	353	6	-	-	SYM
finefocus-2081	353	7	110	110	NUM
finefocus-2081	353	8	.	.	PUNCT
finefocus-2081	354	1	62	62	NUM
finefocus-2081	354	2	.	.	PUNCT
finefocus-2081	355	1	anonymous	anonymous	PROPN
finefocus-2081	355	2	.	.	PUNCT
finefocus-2081	356	1	science	science	NOUN
finefocus-2081	356	2	policy	policy	NOUN
finefocus-2081	356	3	in	in	ADP
finefocus-2081	356	4	the	the	DET
finefocus-2081	356	5	classroom	classroom	NOUN
finefocus-2081	356	6	,	,	PUNCT
finefocus-2081	356	7	on	on	ADP
finefocus-2081	356	8	duke	duke	PROPN
finefocus-2081	356	9	science	science	NOUN
finefocus-2081	356	10	and	and	CCONJ
finefocus-2081	356	11	society	society	NOUN
finefocus-2081	356	12	.	.	PUNCT
finefocus-2081	357	1	2018	2018	NUM
finefocus-2081	357	2	63	63	NUM
finefocus-2081	357	3	.	.	PUNCT
finefocus-2081	358	1	vogel	vogel	PROPN
finefocus-2081	358	2	km	km	PROPN
finefocus-2081	358	3	.	.	PUNCT
finefocus-2081	359	1	crispr	crispr	PROPN
finefocus-2081	359	2	goes	go	VERB
finefocus-2081	359	3	global	global	ADJ
finefocus-2081	359	4	:	:	PUNCT
finefocus-2081	359	5	a	a	DET
finefocus-2081	359	6	snapshot	snapshot	NOUN
finefocus-2081	359	7	of	of	ADP
finefocus-2081	359	8	rules	rule	NOUN
finefocus-2081	359	9	,	,	PUNCT
finefocus-2081	359	10	policies	policy	NOUN
finefocus-2081	359	11	,	,	PUNCT
finefocus-2081	359	12	and	and	CCONJ
finefocus-2081	359	13	attitudes	attitude	NOUN
finefocus-2081	359	14	.	.	PUNCT
finefocus-2081	360	1	2018	2018	NUM
finefocus-2081	360	2	34	34	NUM
finefocus-2081	360	3	•	•	NUM
finefocus-2081	360	4	fine	fine	ADJ
finefocus-2081	360	5	focus	focus	NOUN
finefocus-2081	360	6	,	,	PUNCT
finefocus-2081	360	7	vol	vol	NOUN
finefocus-2081	360	8	5	5	NUM
finefocus-2081	360	9	2019	2019	NUM