id	sid	tid	token	lemma	pos
finefocus-3321	1	1	76	76	NUM
finefocus-3321	1	2	|	|	ADV
finefocus-3321	1	3	fine	fine	ADJ
finefocus-3321	1	4	focus	focus	NOUN
finefocus-3321	1	5	avery	avery	PROPN
finefocus-3321	1	6	m.	m.	PROPN
finefocus-3321	1	7	runnebohm1,2	runnebohm1,2	PROPN
finefocus-3321	1	8	,	,	PUNCT
finefocus-3321	1	9	melissa	melissa	PROPN
finefocus-3321	1	10	d.	d.	PROPN
finefocus-3321	1	11	evans1,2	evans1,2	PROPN
finefocus-3321	1	12	,	,	PUNCT
finefocus-3321	1	13	adam	adam	PROPN
finefocus-3321	1	14	e.	e.	PROPN
finefocus-3321	1	15	richardson1	richardson1	PROPN
finefocus-3321	1	16	,	,	PUNCT
finefocus-3321	1	17	samantha	samantha	PROPN
finefocus-3321	1	18	m.	m.	PROPN
finefocus-3321	1	19	turk1	turk1	PROPN
finefocus-3321	1	20	,	,	PUNCT
finefocus-3321	1	21	james	james	PROPN
finefocus-3321	1	22	b.	b.	PROPN
finefocus-3321	1	23	olesen1	olesen1	PROPN
finefocus-3321	1	24	,	,	PUNCT
finefocus-3321	1	25	philip	philip	PROPN
finefocus-3321	1	26	j.	j.	PROPN
finefocus-3321	1	27	smaldino1	smaldino1	PROPN
finefocus-3321	1	28	,	,	PUNCT
finefocus-3321	1	29	and	and	CCONJ
finefocus-3321	1	30	eric	eric	PROPN
finefocus-3321	1	31	m.	m.	PROPN
finefocus-3321	1	32	rubenstein1,3	rubenstein1,3	PROPN
finefocus-3321	2	1	1	1	X
finefocus-3321	2	2	.	.	PUNCT
finefocus-3321	2	3	ball	ball	NOUN
finefocus-3321	2	4	state	state	PROPN
finefocus-3321	2	5	university	university	PROPN
finefocus-3321	2	6	,	,	PUNCT
finefocus-3321	2	7	department	department	NOUN
finefocus-3321	2	8	of	of	ADP
finefocus-3321	2	9	biology	biology	NOUN
finefocus-3321	2	10	,	,	PUNCT
finefocus-3321	2	11	muncie	muncie	PROPN
finefocus-3321	2	12	,	,	PUNCT
finefocus-3321	2	13	in	in	ADP
finefocus-3321	2	14	47306	47306	NUM
finefocus-3321	2	15	2	2	NUM
finefocus-3321	2	16	.	.	PUNCT
finefocus-3321	3	1	these	these	DET
finefocus-3321	3	2	authors	author	NOUN
finefocus-3321	3	3	contributed	contribute	VERB
finefocus-3321	3	4	equally	equally	ADV
finefocus-3321	3	5	to	to	ADP
finefocus-3321	3	6	this	this	DET
finefocus-3321	3	7	work	work	NOUN
finefocus-3321	3	8	.	.	PUNCT
finefocus-3321	4	1	3	3	X
finefocus-3321	4	2	.	.	X
finefocus-3321	4	3	corresponding	correspond	VERB
finefocus-3321	4	4	author	author	NOUN
finefocus-3321	4	5	author	author	NOUN
finefocus-3321	4	6	email	email	NOUN
finefocus-3321	4	7	addresses	address	NOUN
finefocus-3321	4	8	:	:	PUNCT
finefocus-3321	4	9	avery	avery	PROPN
finefocus-3321	4	10	m.	m.	NOUN
finefocus-3321	4	11	runnebohm	runnebohm	PROPN
finefocus-3321	4	12	:	:	PUNCT
finefocus-3321	4	13	averykirschbaum@yahoo.com	averykirschbaum@yahoo.com	X
finefocus-3321	5	1	melissa	melissa	PROPN
finefocus-3321	5	2	d.	d.	PROPN
finefocus-3321	5	3	evans	evans	PROPN
finefocus-3321	5	4	:	:	PUNCT
finefocus-3321	5	5	melissa.evans96@outlook.com	melissa.evans96@outlook.com	X
finefocus-3321	5	6	adam	adam	PROPN
finefocus-3321	5	7	e.	e.	PROPN
finefocus-3321	5	8	richardson	richardson	PROPN
finefocus-3321	5	9	:	:	PUNCT
finefocus-3321	5	10	aerichardso3@bsu.edu	aerichardso3@bsu.edu	PROPN
finefocus-3321	5	11	samantha	samantha	PROPN
finefocus-3321	5	12	m.	m.	PROPN
finefocus-3321	5	13	turk	turk	PROPN
finefocus-3321	5	14	:	:	PUNCT
finefocus-3321	5	15	smturk@bsu.edu	smturk@bsu.edu	PROPN
finefocus-3321	5	16	james	james	PROPN
finefocus-3321	5	17	b.	b.	PROPN
finefocus-3321	6	1	olesen	olesen	PROPN
finefocus-3321	6	2	:	:	PUNCT
finefocus-3321	6	3	jolesen@bsu.edu	jolesen@bsu.edu	PROPN
finefocus-3321	6	4	philip	philip	PROPN
finefocus-3321	6	5	j.	j.	PROPN
finefocus-3321	6	6	smaldino	smaldino	PROPN
finefocus-3321	6	7	:	:	PUNCT
finefocus-3321	7	1	pjsmaldino@bsu.edu	pjsmaldino@bsu.edu	PROPN
finefocus-3321	7	2	eric	eric	PROPN
finefocus-3321	7	3	m.	m.	PROPN
finefocus-3321	7	4	rubenstein	rubenstein	PROPN
finefocus-3321	7	5	(	(	PUNCT
finefocus-3321	7	6	corresponding	correspond	VERB
finefocus-3321	7	7	author	author	NOUN
finefocus-3321	7	8	):	):	PUNCT
finefocus-3321	7	9	emrubenstein@bsu.edu	emrubenstein@bsu.edu	PROPN
finefocus-3321	7	10	manuscript	manuscript	NOUN
finefocus-3321	7	11	received	receive	VERB
finefocus-3321	7	12	1	1	NUM
finefocus-3321	7	13	october	october	PROPN
finefocus-3321	7	14	2019	2019	NUM
finefocus-3321	7	15	;	;	PUNCT
finefocus-3321	7	16	accepted	accept	VERB
finefocus-3321	7	17	7	7	NUM
finefocus-3321	7	18	february	february	NOUN
finefocus-3321	7	19	2020	2020	NUM
finefocus-3321	7	20	.	.	PUNCT
finefocus-3321	8	1	loss	loss	NOUN
finefocus-3321	8	2	of	of	ADP
finefocus-3321	8	3	protein	protein	NOUN
finefocus-3321	8	4	quality	quality	NOUN
finefocus-3321	8	5	control	control	NOUN
finefocus-3321	8	6	gene	gene	NOUN
finefocus-3321	8	7	ubr1	ubr1	PROPN
finefocus-3321	8	8	 	 	SPACE
finefocus-3321	8	9	sensitizes	sensitize	VERB
finefocus-3321	8	10	saccharomyces	saccharomyce	NOUN
finefocus-3321	8	11	cerevisiae	cerevisiae	NOUN
finefocus-3321	8	12	to	to	ADP
finefocus-3321	8	13	the	the	DET
finefocus-3321	8	14	aminoglycoside	aminoglycoside	ADJ
finefocus-3321	8	15	hygromycin	hygromycin	PROPN
finefocus-3321	8	16	b	b	PROPN
finefocus-3321	8	17	avery	avery	PROPN
finefocus-3321	8	18	m.	m.	PROPN
finefocus-3321	8	19	runnebohm	runnebohm	PROPN
finefocus-3321	8	20	,	,	PUNCT
finefocus-3321	8	21	melissa	melissa	PROPN
finefocus-3321	8	22	d.	d.	PROPN
finefocus-3321	8	23	evans	evans	PROPN
finefocus-3321	8	24	,	,	PUNCT
finefocus-3321	8	25	adam	adam	PROPN
finefocus-3321	8	26	e.	e.	PROPN
finefocus-3321	8	27	richardson	richardson	PROPN
finefocus-3321	8	28	,	,	PUNCT
finefocus-3321	8	29	samantha	samantha	PROPN
finefocus-3321	8	30	m.	m.	PROPN
finefocus-3321	8	31	turk	turk	PROPN
finefocus-3321	8	32	,	,	PUNCT
finefocus-3321	8	33	james	james	PROPN
finefocus-3321	8	34	b.	b.	PROPN
finefocus-3321	8	35	olesen	olesen	PROPN
finefocus-3321	8	36	,	,	PUNCT
finefocus-3321	8	37	philip	philip	PROPN
finefocus-3321	8	38	j.	j.	PROPN
finefocus-3321	8	39	smaldino	smaldino	PROPN
finefocus-3321	8	40	,	,	PUNCT
finefocus-3321	8	41	and	and	CCONJ
finefocus-3321	9	1	eric	eric	PROPN
finefocus-3321	9	2	m.	m.	PROPN
finefocus-3321	9	3	rubenstein	rubenstein	PROPN
finefocus-3321	9	4	volume	volume	PROPN
finefocus-3321	9	5	six	six	NUM
finefocus-3321	9	6	|	|	ADV
finefocus-3321	9	7	77	77	NUM
finefocus-3321	9	8	abstract	abstract	ADJ
finefocus-3321	9	9	ubr1	ubr1	PROPN
finefocus-3321	9	10	is	be	AUX
finefocus-3321	9	11	a	a	DET
finefocus-3321	9	12	conserved	conserved	ADJ
finefocus-3321	9	13	ubiquitin	ubiquitin	NOUN
finefocus-3321	9	14	ligase	ligase	NOUN
finefocus-3321	9	15	involved	involve	VERB
finefocus-3321	9	16	in	in	ADP
finefocus-3321	9	17	the	the	DET
finefocus-3321	9	18	degradation	degradation	NOUN
finefocus-3321	9	19	of	of	ADP
finefocus-3321	9	20	aberrant	aberrant	ADJ
finefocus-3321	9	21	proteins	protein	NOUN
finefocus-3321	9	22	in	in	ADP
finefocus-3321	9	23	eukaryotic	eukaryotic	ADJ
finefocus-3321	9	24	cells	cell	NOUN
finefocus-3321	9	25	.	.	PUNCT
finefocus-3321	10	1	the	the	DET
finefocus-3321	10	2	human	human	ADJ
finefocus-3321	10	3	enzyme	enzyme	NOUN
finefocus-3321	10	4	is	be	AUX
finefocus-3321	10	5	found	find	VERB
finefocus-3321	10	6	mutated	mutate	VERB
finefocus-3321	10	7	in	in	ADP
finefocus-3321	10	8	patients	patient	NOUN
finefocus-3321	10	9	with	with	ADP
finefocus-3321	10	10	johansonblizzard	johansonblizzard	ADJ
finefocus-3321	10	11	syndrome	syndrome	NOUN
finefocus-3321	10	12	.	.	PUNCT
finefocus-3321	11	1	we	we	PRON
finefocus-3321	11	2	hypothesized	hypothesize	VERB
finefocus-3321	11	3	that	that	SCONJ
finefocus-3321	11	4	ubr1	ubr1	PROPN
finefocus-3321	11	5	is	be	AUX
finefocus-3321	11	6	necessary	necessary	ADJ
finefocus-3321	11	7	for	for	ADP
finefocus-3321	11	8	optimal	optimal	ADJ
finefocus-3321	11	9	cellular	cellular	ADJ
finefocus-3321	11	10	fitness	fitness	NOUN
finefocus-3321	11	11	in	in	ADP
finefocus-3321	11	12	conditions	condition	NOUN
finefocus-3321	11	13	associated	associate	VERB
finefocus-3321	11	14	with	with	ADP
finefocus-3321	11	15	elevated	elevated	ADJ
finefocus-3321	11	16	abundance	abundance	NOUN
finefocus-3321	11	17	of	of	ADP
finefocus-3321	11	18	aberrant	aberrant	NOUN
finefocus-3321	11	19	and	and	CCONJ
finefocus-3321	11	20	misfolded	misfolde	VERB
finefocus-3321	11	21	proteins	protein	NOUN
finefocus-3321	11	22	.	.	PUNCT
finefocus-3321	12	1	indeed	indeed	ADV
finefocus-3321	12	2	,	,	PUNCT
finefocus-3321	12	3	we	we	PRON
finefocus-3321	12	4	found	find	VERB
finefocus-3321	12	5	that	that	SCONJ
finefocus-3321	12	6	loss	loss	NOUN
finefocus-3321	12	7	of	of	ADP
finefocus-3321	12	8	ubr1	ubr1	PROPN
finefocus-3321	12	9	in	in	ADP
finefocus-3321	12	10	the	the	DET
finefocus-3321	12	11	model	model	NOUN
finefocus-3321	12	12	eukaryotic	eukaryotic	ADJ
finefocus-3321	12	13	microorganism	microorganism	NOUN
finefocus-3321	12	14	saccharomyces	saccharomyce	NOUN
finefocus-3321	12	15	cerevisiae	cerevisiae	NOUN
finefocus-3321	12	16	strongly	strongly	ADV
finefocus-3321	12	17	sensitizes	sensitize	VERB
finefocus-3321	12	18	cells	cell	NOUN
finefocus-3321	12	19	to	to	ADP
finefocus-3321	12	20	hygromycin	hygromycin	PROPN
finefocus-3321	12	21	b	b	PROPN
finefocus-3321	12	22	,	,	PUNCT
finefocus-3321	12	23	which	which	PRON
finefocus-3321	12	24	reduces	reduce	VERB
finefocus-3321	12	25	translational	translational	ADJ
finefocus-3321	12	26	fidelity	fidelity	NOUN
finefocus-3321	12	27	by	by	ADP
finefocus-3321	12	28	causing	cause	VERB
finefocus-3321	12	29	ribosome	ribosome	ADJ
finefocus-3321	12	30	a	a	DET
finefocus-3321	12	31	site	site	NOUN
finefocus-3321	12	32	distortion	distortion	NOUN
finefocus-3321	12	33	.	.	PUNCT
finefocus-3321	13	1	our	our	PRON
finefocus-3321	13	2	results	result	NOUN
finefocus-3321	13	3	are	be	AUX
finefocus-3321	13	4	consistent	consistent	ADJ
finefocus-3321	13	5	with	with	ADP
finefocus-3321	13	6	a	a	DET
finefocus-3321	13	7	prominent	prominent	ADJ
finefocus-3321	13	8	role	role	NOUN
finefocus-3321	13	9	for	for	ADP
finefocus-3321	13	10	ubr1	ubr1	PROPN
finefocus-3321	13	11	in	in	ADP
finefocus-3321	13	12	protein	protein	NOUN
finefocus-3321	13	13	quality	quality	NOUN
finefocus-3321	13	14	control	control	NOUN
finefocus-3321	13	15	.	.	PUNCT
finefocus-3321	14	1	we	we	PRON
finefocus-3321	14	2	speculate	speculate	VERB
finefocus-3321	14	3	that	that	SCONJ
finefocus-3321	14	4	disease	disease	NOUN
finefocus-3321	14	5	manifestations	manifestation	NOUN
finefocus-3321	14	6	in	in	ADP
finefocus-3321	14	7	patients	patient	NOUN
finefocus-3321	14	8	with	with	ADP
finefocus-3321	14	9	johanson	johanson	PROPN
finefocus-3321	14	10	-	-	PUNCT
finefocus-3321	14	11	blizzard	blizzard	PROPN
finefocus-3321	14	12	syndrome	syndrome	NOUN
finefocus-3321	14	13	are	be	AUX
finefocus-3321	14	14	linked	link	VERB
finefocus-3321	14	15	,	,	PUNCT
finefocus-3321	14	16	at	at	ADP
finefocus-3321	14	17	least	least	ADJ
finefocus-3321	14	18	in	in	ADP
finefocus-3321	14	19	part	part	NOUN
finefocus-3321	14	20	,	,	PUNCT
finefocus-3321	14	21	to	to	ADP
finefocus-3321	14	22	defects	defect	NOUN
finefocus-3321	14	23	in	in	ADP
finefocus-3321	14	24	protein	protein	NOUN
finefocus-3321	14	25	quality	quality	NOUN
finefocus-3321	14	26	control	control	NOUN
finefocus-3321	14	27	caused	cause	VERB
finefocus-3321	14	28	by	by	ADP
finefocus-3321	14	29	loss	loss	NOUN
finefocus-3321	14	30	of	of	ADP
finefocus-3321	14	31	ubr1	ubr1	PROPN
finefocus-3321	14	32	function	function	NOUN
finefocus-3321	14	33	.	.	PUNCT
finefocus-3321	15	1	78	78	NUM
finefocus-3321	15	2	|	|	CCONJ
finefocus-3321	15	3	fine	fine	ADJ
finefocus-3321	15	4	focus	focus	NOUN
finefocus-3321	15	5	introduction	introduction	NOUN
finefocus-3321	15	6	the	the	DET
finefocus-3321	15	7	structure	structure	NOUN
finefocus-3321	15	8	and	and	CCONJ
finefocus-3321	15	9	function	function	NOUN
finefocus-3321	15	10	of	of	ADP
finefocus-3321	15	11	the	the	DET
finefocus-3321	15	12	ubr1	ubr1	PROPN
finefocus-3321	15	13	ubiquitin	ubiquitin	NOUN
finefocus-3321	15	14	ligase	ligase	PROPN
finefocus-3321	15	15	are	be	AUX
finefocus-3321	15	16	conserved	conserve	VERB
finefocus-3321	15	17	across	across	ADP
finefocus-3321	15	18	diverse	diverse	ADJ
finefocus-3321	15	19	eukaryotic	eukaryotic	ADJ
finefocus-3321	15	20	organisms	organism	NOUN
finefocus-3321	15	21	(	(	PUNCT
finefocus-3321	15	22	8)	8)	NUM
finefocus-3321	15	23	.	.	PUNCT
finefocus-3321	16	1	in	in	ADP
finefocus-3321	16	2	humans	human	NOUN
finefocus-3321	16	3	,	,	PUNCT
finefocus-3321	16	4	mutation	mutation	NOUN
finefocus-3321	16	5	of	of	ADP
finefocus-3321	16	6	ubr1	ubr1	PROPN
finefocus-3321	16	7	causes	cause	VERB
finefocus-3321	16	8	johansonblizzard	johansonblizzard	NOUN
finefocus-3321	16	9	syndrome	syndrome	NOUN
finefocus-3321	16	10	,	,	PUNCT
finefocus-3321	16	11	a	a	DET
finefocus-3321	16	12	disorder	disorder	NOUN
finefocus-3321	16	13	characterized	characterize	VERB
finefocus-3321	16	14	by	by	ADP
finefocus-3321	16	15	multiorgan	multiorgan	NOUN
finefocus-3321	16	16	dysfunction	dysfunction	NOUN
finefocus-3321	16	17	,	,	PUNCT
finefocus-3321	16	18	physical	physical	ADJ
finefocus-3321	16	19	malformations	malformation	NOUN
finefocus-3321	16	20	,	,	PUNCT
finefocus-3321	16	21	and	and	CCONJ
finefocus-3321	16	22	cognitive	cognitive	ADJ
finefocus-3321	16	23	impairment	impairment	NOUN
finefocus-3321	16	24	(	(	PUNCT
finefocus-3321	16	25	19	19	NUM
finefocus-3321	16	26	)	)	PUNCT
finefocus-3321	16	27	.	.	PUNCT
finefocus-3321	17	1	ubr1	ubr1	PROPN
finefocus-3321	17	2	has	have	AUX
finefocus-3321	17	3	been	be	AUX
finefocus-3321	17	4	extensively	extensively	ADV
finefocus-3321	17	5	investigated	investigate	VERB
finefocus-3321	17	6	in	in	ADP
finefocus-3321	17	7	the	the	DET
finefocus-3321	17	8	model	model	NOUN
finefocus-3321	17	9	unicellular	unicellular	ADJ
finefocus-3321	17	10	eukaryote	eukaryote	NOUN
finefocus-3321	17	11	saccharomyces	saccharomyce	NOUN
finefocus-3321	17	12	cerevisiae	cerevisiae	NOUN
finefocus-3321	17	13	(	(	PUNCT
finefocus-3321	17	14	budding	bud	VERB
finefocus-3321	17	15	yeast	yeast	NOUN
finefocus-3321	17	16	)	)	PUNCT
finefocus-3321	17	17	,	,	PUNCT
finefocus-3321	17	18	where	where	SCONJ
finefocus-3321	17	19	it	it	PRON
finefocus-3321	17	20	contributes	contribute	VERB
finefocus-3321	17	21	to	to	ADP
finefocus-3321	17	22	multiple	multiple	ADJ
finefocus-3321	17	23	aspects	aspect	NOUN
finefocus-3321	17	24	of	of	ADP
finefocus-3321	17	25	protein	protein	NOUN
finefocus-3321	17	26	quality	quality	NOUN
finefocus-3321	17	27	control	control	NOUN
finefocus-3321	17	28	.	.	PUNCT
finefocus-3321	18	1	experiments	experiment	NOUN
finefocus-3321	18	2	performed	perform	VERB
finefocus-3321	18	3	with	with	ADP
finefocus-3321	18	4	yeast	yeast	NOUN
finefocus-3321	18	5	have	have	AUX
finefocus-3321	18	6	been	be	AUX
finefocus-3321	18	7	foundational	foundational	ADJ
finefocus-3321	18	8	in	in	ADP
finefocus-3321	18	9	the	the	DET
finefocus-3321	18	10	discovery	discovery	NOUN
finefocus-3321	18	11	of	of	ADP
finefocus-3321	18	12	molecular	molecular	ADJ
finefocus-3321	18	13	mechanisms	mechanism	NOUN
finefocus-3321	18	14	of	of	ADP
finefocus-3321	18	15	quality	quality	NOUN
finefocus-3321	18	16	control	control	NOUN
finefocus-3321	18	17	conserved	conserve	VERB
finefocus-3321	18	18	among	among	ADP
finefocus-3321	18	19	eukaryotes	eukaryote	NOUN
finefocus-3321	18	20	(	(	PUNCT
finefocus-3321	18	21	3	3	NUM
finefocus-3321	18	22	)	)	PUNCT
finefocus-3321	18	23	.	.	PUNCT
finefocus-3321	19	1	among	among	ADP
finefocus-3321	19	2	other	other	ADJ
finefocus-3321	19	3	roles	role	NOUN
finefocus-3321	19	4	,	,	PUNCT
finefocus-3321	19	5	ubr1	ubr1	PROPN
finefocus-3321	19	6	promotes	promote	VERB
finefocus-3321	19	7	turnover	turnover	NOUN
finefocus-3321	19	8	of	of	ADP
finefocus-3321	19	9	substrates	substrate	NOUN
finefocus-3321	19	10	of	of	ADP
finefocus-3321	19	11	the	the	DET
finefocus-3321	19	12	n	n	CCONJ
finefocus-3321	19	13	-	-	PUNCT
finefocus-3321	19	14	end	end	NOUN
finefocus-3321	19	15	rule	rule	NOUN
finefocus-3321	19	16	(	(	PUNCT
finefocus-3321	19	17	17	17	NUM
finefocus-3321	19	18	)	)	PUNCT
finefocus-3321	19	19	,	,	PUNCT
finefocus-3321	19	20	endoplasmic	endoplasmic	ADJ
finefocus-3321	19	21	reticulum	reticulum	NOUN
finefocus-3321	19	22	-	-	PUNCT
finefocus-3321	19	23	associated	associate	VERB
finefocus-3321	19	24	degradation	degradation	NOUN
finefocus-3321	19	25	(	(	PUNCT
finefocus-3321	19	26	erad	erad	PROPN
finefocus-3321	19	27	)	)	PUNCT
finefocus-3321	19	28	(	(	PUNCT
finefocus-3321	19	29	12	12	NUM
finefocus-3321	19	30	,	,	PUNCT
finefocus-3321	19	31	13	13	NUM
finefocus-3321	19	32	)	)	PUNCT
finefocus-3321	19	33	,	,	PUNCT
finefocus-3321	19	34	stress	stress	NOUN
finefocus-3321	19	35	-	-	PUNCT
finefocus-3321	19	36	induced	induce	VERB
finefocus-3321	19	37	homeostatically	homeostatically	ADV
finefocus-3321	19	38	regulated	regulate	VERB
finefocus-3321	19	39	protein	protein	NOUN
finefocus-3321	19	40	degradation	degradation	NOUN
finefocus-3321	19	41	(	(	PUNCT
finefocus-3321	19	42	shred	shred	NOUN
finefocus-3321	19	43	)	)	PUNCT
finefocus-3321	19	44	(	(	PUNCT
finefocus-3321	19	45	14	14	NUM
finefocus-3321	19	46	)	)	PUNCT
finefocus-3321	19	47	,	,	PUNCT
finefocus-3321	19	48	and	and	CCONJ
finefocus-3321	19	49	cytoplasmic	cytoplasmic	ADJ
finefocus-3321	19	50	quality	quality	NOUN
finefocus-3321	19	51	control	control	NOUN
finefocus-3321	19	52	(	(	PUNCT
finefocus-3321	19	53	cytoqc	cytoqc	NOUN
finefocus-3321	19	54	)	)	PUNCT
finefocus-3321	19	55	(	(	PUNCT
finefocus-3321	19	56	7	7	NUM
finefocus-3321	19	57	,	,	PUNCT
finefocus-3321	19	58	11	11	NUM
finefocus-3321	19	59	)	)	PUNCT
finefocus-3321	19	60	pathways	pathway	NOUN
finefocus-3321	19	61	.	.	PUNCT
finefocus-3321	20	1	yeast	yeast	NOUN
finefocus-3321	20	2	lacking	lack	VERB
finefocus-3321	20	3	ubr1	ubr1	PROPN
finefocus-3321	20	4	exhibit	exhibit	VERB
finefocus-3321	20	5	divergent	divergent	ADJ
finefocus-3321	20	6	responses	response	NOUN
finefocus-3321	20	7	to	to	ADP
finefocus-3321	20	8	pharmacologic	pharmacologic	ADJ
finefocus-3321	20	9	interventions	intervention	NOUN
finefocus-3321	20	10	expected	expect	VERB
finefocus-3321	20	11	to	to	PART
finefocus-3321	20	12	increase	increase	VERB
finefocus-3321	20	13	the	the	DET
finefocus-3321	20	14	abundance	abundance	NOUN
finefocus-3321	20	15	of	of	ADP
finefocus-3321	20	16	misfolded	misfolde	VERB
finefocus-3321	20	17	proteins	protein	NOUN
finefocus-3321	20	18	.	.	PUNCT
finefocus-3321	21	1	for	for	ADP
finefocus-3321	21	2	example	example	NOUN
finefocus-3321	21	3	,	,	PUNCT
finefocus-3321	21	4	ubr1∆	ubr1∆	VERB
finefocus-3321	21	5	yeast	yeast	NOUN
finefocus-3321	21	6	display	display	NOUN
finefocus-3321	21	7	enhanced	enhance	VERB
finefocus-3321	21	8	sensitivity	sensitivity	NOUN
finefocus-3321	21	9	to	to	ADP
finefocus-3321	21	10	the	the	DET
finefocus-3321	21	11	hsp90	hsp90	ADJ
finefocus-3321	21	12	inhibitor	inhibitor	NOUN
finefocus-3321	21	13	geldanamycin	geldanamycin	NOUN
finefocus-3321	21	14	,	,	PUNCT
finefocus-3321	21	15	while	while	SCONJ
finefocus-3321	21	16	they	they	PRON
finefocus-3321	21	17	are	be	AUX
finefocus-3321	21	18	resistant	resistant	ADJ
finefocus-3321	21	19	to	to	ADP
finefocus-3321	21	20	the	the	DET
finefocus-3321	21	21	proline	proline	NOUN
finefocus-3321	21	22	analog	analog	NOUN
finefocus-3321	21	23	l	l	PROPN
finefocus-3321	21	24	-	-	PUNCT
finefocus-3321	21	25	azetidine-2	azetidine-2	ADJ
finefocus-3321	21	26	-	-	PUNCT
finefocus-3321	21	27	carboxylic	carboxylic	ADJ
finefocus-3321	21	28	acid	acid	NOUN
finefocus-3321	21	29	(	(	PUNCT
finefocus-3321	21	30	15	15	NUM
finefocus-3321	21	31	)	)	PUNCT
finefocus-3321	21	32	.	.	PUNCT
finefocus-3321	22	1	materials	material	NOUN
finefocus-3321	22	2	all	all	DET
finefocus-3321	22	3	yeast	yeast	NOUN
finefocus-3321	22	4	strains	strain	NOUN
finefocus-3321	22	5	used	use	VERB
finefocus-3321	22	6	in	in	ADP
finefocus-3321	22	7	this	this	DET
finefocus-3321	22	8	study	study	NOUN
finefocus-3321	22	9	are	be	AUX
finefocus-3321	22	10	presented	present	VERB
finefocus-3321	22	11	in	in	ADP
finefocus-3321	22	12	table	table	NOUN
finefocus-3321	22	13	1	1	NUM
finefocus-3321	22	14	.	.	PUNCT
finefocus-3321	23	1	these	these	DET
finefocus-3321	23	2	strains	strain	NOUN
finefocus-3321	23	3	have	have	AUX
finefocus-3321	23	4	been	be	AUX
finefocus-3321	23	5	constructed	construct	VERB
finefocus-3321	23	6	in	in	ADP
finefocus-3321	23	7	previous	previous	ADJ
finefocus-3321	23	8	reports	report	NOUN
finefocus-3321	23	9	(	(	PUNCT
finefocus-3321	23	10	6	6	NUM
finefocus-3321	23	11	,	,	PUNCT
finefocus-3321	23	12	16	16	NUM
finefocus-3321	23	13	)	)	PUNCT
finefocus-3321	23	14	.	.	PUNCT
finefocus-3321	24	1	the	the	DET
finefocus-3321	24	2	entire	entire	ADJ
finefocus-3321	24	3	coding	code	VERB
finefocus-3321	24	4	sequences	sequence	NOUN
finefocus-3321	24	5	of	of	ADP
finefocus-3321	24	6	ubr1	ubr1	PROPN
finefocus-3321	24	7	,	,	PUNCT
finefocus-3321	24	8	hrd1	hrd1	PROPN
finefocus-3321	24	9	,	,	PUNCT
finefocus-3321	24	10	and	and	CCONJ
finefocus-3321	24	11	doa10	doa10	PROPN
finefocus-3321	24	12	have	have	AUX
finefocus-3321	24	13	been	be	AUX
finefocus-3321	24	14	replaced	replace	VERB
finefocus-3321	24	15	with	with	ADP
finefocus-3321	24	16	the	the	DET
finefocus-3321	24	17	kanmx4	kanmx4	NOUN
finefocus-3321	24	18	allele	allele	NOUN
finefocus-3321	24	19	in	in	ADP
finefocus-3321	24	20	gene	gene	NOUN
finefocus-3321	24	21	knockout	knockout	NOUN
finefocus-3321	24	22	strains	strain	NOUN
finefocus-3321	24	23	(	(	PUNCT
finefocus-3321	24	24	16	16	NUM
finefocus-3321	24	25	)	)	PUNCT
finefocus-3321	24	26	.	.	PUNCT
finefocus-3321	25	1	yeast	yeast	NOUN
finefocus-3321	25	2	were	be	AUX
finefocus-3321	25	3	cultured	cultured	ADJ
finefocus-3321	25	4	in	in	ADP
finefocus-3321	25	5	yeast	yeast	NOUN
finefocus-3321	25	6	extract	extract	NOUN
finefocus-3321	25	7	-	-	PUNCT
finefocus-3321	25	8	peptonedextrose	peptonedextrose	NOUN
finefocus-3321	25	9	medium	medium	NOUN
finefocus-3321	25	10	(	(	PUNCT
finefocus-3321	25	11	1	1	NUM
finefocus-3321	25	12	%	%	NOUN
finefocus-3321	25	13	yeast	yeast	NOUN
finefocus-3321	25	14	extract	extract	NOUN
finefocus-3321	25	15	,	,	PUNCT
finefocus-3321	25	16	2	2	NUM
finefocus-3321	25	17	%	%	NOUN
finefocus-3321	25	18	peptone	peptone	NOUN
finefocus-3321	25	19	,	,	PUNCT
finefocus-3321	25	20	2	2	NUM
finefocus-3321	25	21	%	%	NOUN
finefocus-3321	25	22	glucose	glucose	NOUN
finefocus-3321	25	23	,	,	PUNCT
finefocus-3321	25	24	0.002	0.002	NUM
finefocus-3321	25	25	%	%	NOUN
finefocus-3321	25	26	adenine	adenine	NOUN
finefocus-3321	25	27	,	,	PUNCT
finefocus-3321	25	28	2	2	NUM
finefocus-3321	25	29	%	%	NOUN
finefocus-3321	25	30	agar	agar	NOUN
finefocus-3321	25	31	)	)	PUNCT
finefocus-3321	25	32	(	(	PUNCT
finefocus-3321	25	33	5	5	NUM
finefocus-3321	25	34	)	)	PUNCT
finefocus-3321	25	35	with	with	ADP
finefocus-3321	25	36	the	the	DET
finefocus-3321	25	37	indicated	indicate	VERB
finefocus-3321	25	38	concentrations	concentration	NOUN
finefocus-3321	25	39	of	of	ADP
finefocus-3321	25	40	hygromycin	hygromycin	PROPN
finefocus-3321	25	41	b	b	PROPN
finefocus-3321	25	42	(	(	PUNCT
finefocus-3321	25	43	corning	corning	NOUN
finefocus-3321	25	44	)	)	PUNCT
finefocus-3321	25	45	.	.	PUNCT
finefocus-3321	26	1	methodology	methodology	NOUN
finefocus-3321	26	2	and	and	CCONJ
finefocus-3321	26	3	results	result	NOUN
finefocus-3321	26	4	we	we	PRON
finefocus-3321	26	5	tested	test	VERB
finefocus-3321	26	6	the	the	DET
finefocus-3321	26	7	hypothesis	hypothesis	NOUN
finefocus-3321	26	8	that	that	PRON
finefocus-3321	26	9	ubr1	ubr1	PROPN
finefocus-3321	26	10	is	be	AUX
finefocus-3321	26	11	necessary	necessary	ADJ
finefocus-3321	26	12	for	for	ADP
finefocus-3321	26	13	optimal	optimal	ADJ
finefocus-3321	26	14	growth	growth	NOUN
finefocus-3321	26	15	in	in	ADP
finefocus-3321	26	16	conditions	condition	NOUN
finefocus-3321	26	17	associated	associate	VERB
finefocus-3321	26	18	with	with	ADP
finefocus-3321	26	19	elevated	elevated	ADJ
finefocus-3321	26	20	abundance	abundance	NOUN
finefocus-3321	26	21	of	of	ADP
finefocus-3321	26	22	aberrant	aberrant	ADJ
finefocus-3321	26	23	proteins	protein	NOUN
finefocus-3321	26	24	.	.	PUNCT
finefocus-3321	27	1	the	the	DET
finefocus-3321	27	2	aminoglycoside	aminoglycoside	ADJ
finefocus-3321	27	3	hygromycin	hygromycin	PROPN
finefocus-3321	27	4	b	b	PROPN
finefocus-3321	27	5	reduces	reduce	VERB
finefocus-3321	27	6	translational	translational	ADJ
finefocus-3321	27	7	fidelity	fidelity	NOUN
finefocus-3321	27	8	by	by	ADP
finefocus-3321	27	9	causing	cause	VERB
finefocus-3321	27	10	ribosome	ribosome	ADJ
finefocus-3321	27	11	a	a	DET
finefocus-3321	27	12	site	site	NOUN
finefocus-3321	27	13	distortion	distortion	NOUN
finefocus-3321	27	14	and	and	CCONJ
finefocus-3321	27	15	is	be	AUX
finefocus-3321	27	16	toxic	toxic	ADJ
finefocus-3321	27	17	to	to	ADP
finefocus-3321	27	18	yeast	yeast	NOUN
finefocus-3321	27	19	at	at	ADP
finefocus-3321	27	20	200	200	NUM
finefocus-3321	27	21	µg	µg	NOUN
finefocus-3321	27	22	/	/	SYM
finefocus-3321	27	23	ml	ml	NOUN
finefocus-3321	27	24	(	(	PUNCT
finefocus-3321	27	25	1	1	NUM
finefocus-3321	27	26	,	,	PUNCT
finefocus-3321	27	27	4	4	NUM
finefocus-3321	27	28	,	,	PUNCT
finefocus-3321	27	29	9	9	NUM
finefocus-3321	27	30	)	)	PUNCT
finefocus-3321	27	31	.	.	PUNCT
finefocus-3321	28	1	we	we	PRON
finefocus-3321	28	2	analyzed	analyze	VERB
finefocus-3321	28	3	the	the	DET
finefocus-3321	28	4	growth	growth	NOUN
finefocus-3321	28	5	of	of	ADP
finefocus-3321	28	6	yeast	yeast	NOUN
finefocus-3321	28	7	lacking	lack	VERB
finefocus-3321	28	8	ubr1	ubr1	PROPN
finefocus-3321	28	9	in	in	ADP
finefocus-3321	28	10	the	the	DET
finefocus-3321	28	11	presence	presence	NOUN
finefocus-3321	28	12	of	of	ADP
finefocus-3321	28	13	sublethal	sublethal	NOUN
finefocus-3321	28	14	doses	dose	NOUN
finefocus-3321	28	15	of	of	ADP
finefocus-3321	28	16	hygromycin	hygromycin	PROPN
finefocus-3321	28	17	b	b	PROPN
finefocus-3321	28	18	,	,	PUNCT
finefocus-3321	28	19	which	which	PRON
finefocus-3321	28	20	are	be	AUX
finefocus-3321	28	21	expected	expect	VERB
finefocus-3321	28	22	to	to	PART
finefocus-3321	28	23	increase	increase	VERB
finefocus-3321	28	24	the	the	DET
finefocus-3321	28	25	cellular	cellular	ADJ
finefocus-3321	28	26	concentration	concentration	NOUN
finefocus-3321	28	27	of	of	ADP
finefocus-3321	28	28	misfolded	misfolde	VERB
finefocus-3321	28	29	proteins	protein	NOUN
finefocus-3321	28	30	(	(	PUNCT
finefocus-3321	28	31	figure	figure	NOUN
finefocus-3321	28	32	1	1	NUM
finefocus-3321	28	33	)	)	PUNCT
finefocus-3321	28	34	.	.	PUNCT
finefocus-3321	29	1	wild	wild	ADJ
finefocus-3321	29	2	type	type	NOUN
finefocus-3321	29	3	yeast	yeast	NOUN
finefocus-3321	29	4	,	,	PUNCT
finefocus-3321	29	5	ubr1∆	ubr1∆	VERB
finefocus-3321	29	6	yeast	yeast	NOUN
finefocus-3321	29	7	,	,	PUNCT
finefocus-3321	29	8	and	and	CCONJ
finefocus-3321	29	9	yeast	yeast	NOUN
finefocus-3321	29	10	lacking	lack	VERB
finefocus-3321	29	11	one	one	NUM
finefocus-3321	29	12	or	or	CCONJ
finefocus-3321	29	13	both	both	DET
finefocus-3321	29	14	genes	gene	NOUN
finefocus-3321	29	15	encoding	encode	VERB
finefocus-3321	29	16	the	the	DET
finefocus-3321	29	17	primary	primary	ADJ
finefocus-3321	29	18	erad	erad	ADJ
finefocus-3321	29	19	ubiquitin	ubiquitin	NOUN
finefocus-3321	29	20	ligases	ligase	NOUN
finefocus-3321	29	21	(	(	PUNCT
finefocus-3321	29	22	hrd1	hrd1	NOUN
finefocus-3321	29	23	and	and	CCONJ
finefocus-3321	29	24	doa10	doa10	PROPN
finefocus-3321	29	25	)	)	PUNCT
finefocus-3321	29	26	(	(	PUNCT
finefocus-3321	29	27	10	10	NUM
finefocus-3321	29	28	)	)	PUNCT
finefocus-3321	29	29	were	be	AUX
finefocus-3321	29	30	subjected	subject	VERB
finefocus-3321	29	31	to	to	ADP
finefocus-3321	29	32	six	six	NUM
finefocus-3321	29	33	-	-	ADJ
finefocus-3321	29	34	fold	fold	ADJ
finefocus-3321	29	35	serial	serial	ADJ
finefocus-3321	29	36	dilution	dilution	NOUN
finefocus-3321	29	37	,	,	PUNCT
finefocus-3321	29	38	beginning	begin	VERB
finefocus-3321	29	39	with	with	ADP
finefocus-3321	29	40	an	an	DET
finefocus-3321	29	41	optical	optical	ADJ
finefocus-3321	29	42	density	density	NOUN
finefocus-3321	29	43	at	at	ADP
finefocus-3321	29	44	600	600	NUM
finefocus-3321	29	45	nm	nm	NOUN
finefocus-3321	29	46	of	of	ADP
finefocus-3321	29	47	0.2	0.2	NUM
finefocus-3321	29	48	.	.	PUNCT
finefocus-3321	30	1	each	each	DET
finefocus-3321	30	2	dilution	dilution	NOUN
finefocus-3321	30	3	(	(	PUNCT
finefocus-3321	30	4	4	4	NUM
finefocus-3321	30	5	µl	µl	NOUN
finefocus-3321	30	6	)	)	PUNCT
finefocus-3321	30	7	was	be	AUX
finefocus-3321	30	8	spotted	spot	VERB
finefocus-3321	30	9	onto	onto	ADP
finefocus-3321	30	10	agar	agar	NOUN
finefocus-3321	30	11	plates	plate	NOUN
finefocus-3321	30	12	containing	contain	VERB
finefocus-3321	30	13	rich	rich	ADJ
finefocus-3321	30	14	yeast	yeast	NOUN
finefocus-3321	30	15	growth	growth	NOUN
finefocus-3321	30	16	medium	medium	NOUN
finefocus-3321	30	17	with	with	ADP
finefocus-3321	30	18	no	no	DET
finefocus-3321	30	19	drug	drug	NOUN
finefocus-3321	30	20	or	or	CCONJ
finefocus-3321	30	21	increasing	increase	VERB
finefocus-3321	30	22	concentrations	concentration	NOUN
finefocus-3321	30	23	of	of	ADP
finefocus-3321	30	24	hygromycin	hygromycin	PROPN
finefocus-3321	30	25	b.	b.	PROPN
finefocus-3321	30	26	plates	plate	NOUN
finefocus-3321	30	27	were	be	AUX
finefocus-3321	30	28	incubated	incubate	VERB
finefocus-3321	30	29	at	at	ADP
finefocus-3321	30	30	30	30	NUM
finefocus-3321	30	31	°	°	NOUN
finefocus-3321	30	32	c	c	NOUN
finefocus-3321	30	33	and	and	CCONJ
finefocus-3321	30	34	imaged	image	VERB
finefocus-3321	30	35	at	at	ADP
finefocus-3321	30	36	the	the	DET
finefocus-3321	30	37	indicated	indicate	VERB
finefocus-3321	30	38	times	time	NOUN
finefocus-3321	30	39	.	.	PUNCT
finefocus-3321	31	1	a	a	DET
finefocus-3321	31	2	detailed	detailed	ADJ
finefocus-3321	31	3	explanation	explanation	NOUN
finefocus-3321	31	4	of	of	ADP
finefocus-3321	31	5	the	the	DET
finefocus-3321	31	6	yeast	yeast	NOUN
finefocus-3321	31	7	growth	growth	NOUN
finefocus-3321	31	8	assay	assay	NOUN
finefocus-3321	31	9	procedure	procedure	NOUN
finefocus-3321	31	10	can	can	AUX
finefocus-3321	31	11	be	be	AUX
finefocus-3321	31	12	found	find	VERB
finefocus-3321	31	13	in	in	ADP
finefocus-3321	31	14	(	(	PUNCT
finefocus-3321	31	15	18	18	NUM
finefocus-3321	31	16	)	)	PUNCT
finefocus-3321	31	17	.	.	PUNCT
finefocus-3321	32	1	all	all	DET
finefocus-3321	32	2	data	datum	NOUN
finefocus-3321	32	3	were	be	AUX
finefocus-3321	32	4	analyzed	analyze	VERB
finefocus-3321	32	5	using	use	VERB
finefocus-3321	32	6	prism	prism	NOUN
finefocus-3321	32	7	software	software	NOUN
finefocus-3321	32	8	(	(	PUNCT
finefocus-3321	32	9	graphpad	graphpad	PROPN
finefocus-3321	32	10	software	software	PROPN
finefocus-3321	32	11	inc	inc	PROPN
finefocus-3321	32	12	.	.	PROPN
finefocus-3321	32	13	,	,	PUNCT
finefocus-3321	32	14	san	san	PROPN
finefocus-3321	32	15	diego	diego	PROPN
finefocus-3321	32	16	,	,	PUNCT
finefocus-3321	32	17	ca	ca	NOUN
finefocus-3321	32	18	)	)	PUNCT
finefocus-3321	32	19	.	.	PUNCT
finefocus-3321	33	1	because	because	SCONJ
finefocus-3321	33	2	of	of	ADP
finefocus-3321	33	3	highly	highly	ADV
finefocus-3321	33	4	variable	variable	ADJ
finefocus-3321	33	5	data	datum	NOUN
finefocus-3321	33	6	,	,	PUNCT
finefocus-3321	33	7	values	value	NOUN
finefocus-3321	33	8	of	of	ADP
finefocus-3321	33	9	zero	zero	NUM
finefocus-3321	33	10	were	be	AUX
finefocus-3321	33	11	normalized	normalize	VERB
finefocus-3321	33	12	to	to	ADP
finefocus-3321	33	13	1	1	NUM
finefocus-3321	33	14	to	to	PART
finefocus-3321	33	15	make	make	VERB
finefocus-3321	33	16	all	all	DET
finefocus-3321	33	17	data	datum	NOUN
finefocus-3321	33	18	positive	positive	ADJ
finefocus-3321	33	19	and	and	CCONJ
finefocus-3321	33	20	positive	positive	ADJ
finefocus-3321	33	21	data	datum	NOUN
finefocus-3321	33	22	were	be	AUX
finefocus-3321	33	23	log	log	NOUN
finefocus-3321	33	24	-	-	PUNCT
finefocus-3321	33	25	transformed	transform	VERB
finefocus-3321	33	26	.	.	PUNCT
finefocus-3321	34	1	all	all	DET
finefocus-3321	34	2	means	mean	NOUN
finefocus-3321	34	3	between	between	ADP
finefocus-3321	34	4	groups	group	NOUN
finefocus-3321	34	5	were	be	AUX
finefocus-3321	34	6	compared	compare	VERB
finefocus-3321	34	7	by	by	ADP
finefocus-3321	34	8	one	one	NUM
finefocus-3321	34	9	-	-	PUNCT
finefocus-3321	34	10	way	way	NOUN
finefocus-3321	34	11	anova	anova	PROPN
finefocus-3321	34	12	followed	follow	VERB
finefocus-3321	34	13	by	by	ADP
finefocus-3321	34	14	tukey	tukey	PROPN
finefocus-3321	34	15	post	post	ADJ
finefocus-3321	34	16	-	-	ADJ
finefocus-3321	34	17	hoc	hoc	ADJ
finefocus-3321	34	18	analysis	analysis	NOUN
finefocus-3321	34	19	.	.	PUNCT
finefocus-3321	35	1	a	a	DET
finefocus-3321	35	2	p	p	NOUN
finefocus-3321	35	3	value	value	NOUN
finefocus-3321	35	4	less	less	ADJ
finefocus-3321	35	5	than	than	ADP
finefocus-3321	35	6	0.05	0.05	NUM
finefocus-3321	35	7	was	be	AUX
finefocus-3321	35	8	designated	designate	VERB
finefocus-3321	35	9	as	as	ADP
finefocus-3321	35	10	statistically	statistically	ADV
finefocus-3321	35	11	significant	significant	ADJ
finefocus-3321	35	12	.	.	PUNCT
finefocus-3321	36	1	in	in	ADP
finefocus-3321	36	2	the	the	DET
finefocus-3321	36	3	absence	absence	NOUN
finefocus-3321	36	4	of	of	ADP
finefocus-3321	36	5	hygromycin	hygromycin	PROPN
finefocus-3321	36	6	b	b	PROPN
finefocus-3321	36	7	,	,	PUNCT
finefocus-3321	36	8	all	all	DET
finefocus-3321	36	9	yeast	yeast	NOUN
finefocus-3321	36	10	strains	strain	NOUN
finefocus-3321	36	11	exhibited	exhibit	VERB
finefocus-3321	36	12	similar	similar	ADJ
finefocus-3321	36	13	growth	growth	NOUN
finefocus-3321	36	14	.	.	PUNCT
finefocus-3321	37	1	consistent	consistent	ADJ
finefocus-3321	37	2	with	with	ADP
finefocus-3321	37	3	previous	previous	ADJ
finefocus-3321	37	4	results	result	NOUN
finefocus-3321	37	5	(	(	PUNCT
finefocus-3321	37	6	2	2	NUM
finefocus-3321	37	7	)	)	PUNCT
finefocus-3321	37	8	,	,	PUNCT
finefocus-3321	37	9	yeast	yeast	NOUN
finefocus-3321	37	10	lacking	lack	VERB
finefocus-3321	37	11	both	both	DET
finefocus-3321	37	12	hrd1	hrd1	NOUN
finefocus-3321	37	13	and	and	CCONJ
finefocus-3321	37	14	doa10	doa10	AUX
finefocus-3321	37	15	exhibited	exhibit	VERB
finefocus-3321	37	16	a	a	DET
finefocus-3321	37	17	pronounced	pronounce	VERB
finefocus-3321	37	18	growth	growth	NOUN
finefocus-3321	37	19	defect	defect	NOUN
finefocus-3321	37	20	in	in	ADP
finefocus-3321	37	21	the	the	DET
finefocus-3321	37	22	presence	presence	NOUN
finefocus-3321	37	23	of	of	ADP
finefocus-3321	37	24	75	75	NUM
finefocus-3321	37	25	µg	µg	NOUN
finefocus-3321	37	26	/	/	SYM
finefocus-3321	37	27	ml	ml	NOUN
finefocus-3321	37	28	hygromycin	hygromycin	PROPN
finefocus-3321	37	29	b.	b.	PROPN
finefocus-3321	37	30	individual	individual	ADJ
finefocus-3321	37	31	deletion	deletion	NOUN
finefocus-3321	37	32	of	of	ADP
finefocus-3321	37	33	hrd1	hrd1	NOUN
finefocus-3321	37	34	or	or	CCONJ
finefocus-3321	37	35	doa10	doa10	PROPN
finefocus-3321	37	36	also	also	ADV
finefocus-3321	37	37	impaired	impair	VERB
finefocus-3321	37	38	growth	growth	NOUN
finefocus-3321	37	39	in	in	ADP
finefocus-3321	37	40	the	the	DET
finefocus-3321	37	41	presence	presence	NOUN
finefocus-3321	37	42	of	of	ADP
finefocus-3321	37	43	hygromycin	hygromycin	PROPN
finefocus-3321	37	44	b	b	PROPN
finefocus-3321	37	45	,	,	PUNCT
finefocus-3321	37	46	but	but	CCONJ
finefocus-3321	37	47	to	to	ADP
finefocus-3321	37	48	a	a	DET
finefocus-3321	37	49	lesser	less	ADJ
finefocus-3321	37	50	extent	extent	NOUN
finefocus-3321	37	51	than	than	ADP
finefocus-3321	37	52	the	the	DET
finefocus-3321	37	53	double	double	ADJ
finefocus-3321	37	54	mutant	mutant	NOUN
finefocus-3321	37	55	.	.	PUNCT
finefocus-3321	38	1	finally	finally	ADV
finefocus-3321	38	2	,	,	PUNCT
finefocus-3321	38	3	loss	loss	NOUN
finefocus-3321	38	4	of	of	ADP
finefocus-3321	38	5	ubr1	ubr1	PROPN
finefocus-3321	38	6	impaired	impaired	ADJ
finefocus-3321	38	7	growth	growth	NOUN
finefocus-3321	38	8	in	in	ADP
finefocus-3321	38	9	the	the	DET
finefocus-3321	38	10	presence	presence	NOUN
finefocus-3321	38	11	of	of	ADP
finefocus-3321	38	12	the	the	DET
finefocus-3321	38	13	compound	compound	NOUN
finefocus-3321	38	14	more	more	ADV
finefocus-3321	38	15	severely	severely	ADV
finefocus-3321	38	16	than	than	ADP
finefocus-3321	38	17	any	any	PRON
finefocus-3321	38	18	of	of	ADP
finefocus-3321	38	19	the	the	DET
finefocus-3321	38	20	other	other	ADJ
finefocus-3321	38	21	mutations	mutation	NOUN
finefocus-3321	38	22	tested	test	VERB
finefocus-3321	38	23	;	;	PUNCT
finefocus-3321	38	24	this	this	PRON
finefocus-3321	38	25	is	be	AUX
finefocus-3321	38	26	most	most	ADV
finefocus-3321	38	27	evident	evident	ADJ
finefocus-3321	38	28	at	at	ADP
finefocus-3321	38	29	50	50	NUM
finefocus-3321	38	30	µg	µg	NOUN
finefocus-3321	38	31	/	/	SYM
finefocus-3321	38	32	ml	ml	NOUN
finefocus-3321	38	33	hygromycin	hygromycin	PROPN
finefocus-3321	38	34	b.	b.	PROPN
finefocus-3321	39	1	this	this	DET
finefocus-3321	39	2	experiment	experiment	NOUN
finefocus-3321	39	3	was	be	AUX
finefocus-3321	39	4	piloted	pilot	VERB
finefocus-3321	39	5	by	by	ADP
finefocus-3321	39	6	undergraduate	undergraduate	ADJ
finefocus-3321	39	7	volume	volume	NOUN
finefocus-3321	39	8	six	six	NUM
finefocus-3321	39	9	|	|	ADV
finefocus-3321	39	10	79	79	NUM
finefocus-3321	39	11	figure	figure	NOUN
finefocus-3321	39	12	1	1	NUM
finefocus-3321	39	13	.	.	PUNCT
finefocus-3321	40	1	loss	loss	NOUN
finefocus-3321	40	2	of	of	ADP
finefocus-3321	40	3	ubr1	ubr1	PROPN
finefocus-3321	40	4	sensitizes	sensitize	VERB
finefocus-3321	40	5	yeast	yeast	NOUN
finefocus-3321	40	6	to	to	ADP
finefocus-3321	40	7	hygromycin	hygromycin	PROPN
finefocus-3321	40	8	b.	b.	PROPN
finefocus-3321	40	9	(	(	PUNCT
finefocus-3321	40	10	a	a	X
finefocus-3321	40	11	)	)	PUNCT
finefocus-3321	40	12	six	six	NUM
finefocus-3321	40	13	-	-	ADJ
finefocus-3321	40	14	fold	fold	ADJ
finefocus-3321	40	15	serial	serial	ADJ
finefocus-3321	40	16	dilutions	dilution	NOUN
finefocus-3321	40	17	of	of	ADP
finefocus-3321	40	18	yeast	yeast	NOUN
finefocus-3321	40	19	of	of	ADP
finefocus-3321	40	20	the	the	DET
finefocus-3321	40	21	indicated	indicate	VERB
finefocus-3321	40	22	genotypes	genotype	NOUN
finefocus-3321	40	23	were	be	AUX
finefocus-3321	40	24	spotted	spot	VERB
finefocus-3321	40	25	onto	onto	ADP
finefocus-3321	40	26	agar	agar	NOUN
finefocus-3321	40	27	plates	plate	NOUN
finefocus-3321	40	28	containing	contain	VERB
finefocus-3321	40	29	rich	rich	ADJ
finefocus-3321	40	30	medium	medium	NOUN
finefocus-3321	40	31	(	(	PUNCT
finefocus-3321	40	32	no	no	DET
finefocus-3321	40	33	drug	drug	NOUN
finefocus-3321	40	34	)	)	PUNCT
finefocus-3321	40	35	or	or	CCONJ
finefocus-3321	40	36	rich	rich	ADJ
finefocus-3321	40	37	medium	medium	NOUN
finefocus-3321	40	38	containing	contain	VERB
finefocus-3321	40	39	increasing	increase	VERB
finefocus-3321	40	40	concentrations	concentration	NOUN
finefocus-3321	40	41	of	of	ADP
finefocus-3321	40	42	hygromycin	hygromycin	PROPN
finefocus-3321	40	43	b.	b.	PROPN
finefocus-3321	40	44	plates	plate	NOUN
finefocus-3321	40	45	were	be	AUX
finefocus-3321	40	46	imaged	image	VERB
finefocus-3321	40	47	after	after	ADP
finefocus-3321	40	48	1	1	NUM
finefocus-3321	40	49	-	-	SYM
finefocus-3321	40	50	2	2	NUM
finefocus-3321	40	51	days	day	NOUN
finefocus-3321	40	52	(	(	PUNCT
finefocus-3321	40	53	as	as	SCONJ
finefocus-3321	40	54	indicated	indicate	VERB
finefocus-3321	40	55	)	)	PUNCT
finefocus-3321	40	56	of	of	ADP
finefocus-3321	40	57	incubation	incubation	NOUN
finefocus-3321	40	58	at	at	ADP
finefocus-3321	40	59	30oc	30oc	PROPN
finefocus-3321	40	60	.	.	PUNCT
finefocus-3321	41	1	(	(	PUNCT
finefocus-3321	41	2	b	b	X
finefocus-3321	41	3	)	)	PUNCT
finefocus-3321	41	4	growth	growth	NOUN
finefocus-3321	41	5	in	in	ADP
finefocus-3321	41	6	the	the	DET
finefocus-3321	41	7	second	second	ADJ
finefocus-3321	41	8	column	column	NOUN
finefocus-3321	41	9	of	of	ADP
finefocus-3321	41	10	each	each	DET
finefocus-3321	41	11	plate	plate	NOUN
finefocus-3321	41	12	(	(	PUNCT
finefocus-3321	41	13	dashed	dash	VERB
finefocus-3321	41	14	rectangles	rectangle	NOUN
finefocus-3321	41	15	)	)	PUNCT
finefocus-3321	41	16	from	from	ADP
finefocus-3321	41	17	three	three	NUM
finefocus-3321	41	18	replicate	replicate	ADJ
finefocus-3321	41	19	experiments	experiment	NOUN
finefocus-3321	41	20	was	be	AUX
finefocus-3321	41	21	quantified	quantify	VERB
finefocus-3321	41	22	by	by	ADP
finefocus-3321	41	23	densitometry	densitometry	NOUN
finefocus-3321	41	24	.	.	PUNCT
finefocus-3321	42	1	data	datum	NOUN
finefocus-3321	42	2	were	be	AUX
finefocus-3321	42	3	analyzed	analyze	VERB
finefocus-3321	42	4	by	by	ADP
finefocus-3321	42	5	one	one	NUM
finefocus-3321	42	6	-	-	PUNCT
finefocus-3321	42	7	way	way	NOUN
finefocus-3321	42	8	anova	anova	PROPN
finefocus-3321	42	9	followed	follow	VERB
finefocus-3321	42	10	by	by	ADP
finefocus-3321	42	11	tukey	tukey	PROPN
finefocus-3321	42	12	post	post	ADJ
finefocus-3321	42	13	-	-	ADJ
finefocus-3321	42	14	hoc	hoc	ADJ
finefocus-3321	42	15	analysis	analysis	NOUN
finefocus-3321	42	16	(	(	PUNCT
finefocus-3321	42	17	*	*	NOUN
finefocus-3321	42	18	,	,	PUNCT
finefocus-3321	42	19	less	less	ADJ
finefocus-3321	42	20	than	than	ADP
finefocus-3321	42	21	wild	wild	ADJ
finefocus-3321	42	22	type	type	NOUN
finefocus-3321	42	23	;	;	PUNCT
finefocus-3321	42	24	*	*	PUNCT
finefocus-3321	42	25	*	*	PUNCT
finefocus-3321	42	26	,	,	PUNCT
finefocus-3321	42	27	less	less	ADJ
finefocus-3321	42	28	than	than	ADP
finefocus-3321	42	29	wild	wild	ADJ
finefocus-3321	42	30	type	type	NOUN
finefocus-3321	42	31	,	,	PUNCT
finefocus-3321	42	32	hrd1δ	hrd1δ	PROPN
finefocus-3321	42	33	,	,	PUNCT
finefocus-3321	42	34	doa10δ	doa10δ	ADJ
finefocus-3321	42	35	,	,	PUNCT
finefocus-3321	42	36	and	and	CCONJ
finefocus-3321	42	37	hrd1δ	hrd1δ	PROPN
finefocus-3321	42	38	doa10δ	doa10δ	PROPN
finefocus-3321	42	39	;	;	PUNCT
finefocus-3321	42	40	p	p	X
finefocus-3321	42	41	<	<	X
finefocus-3321	42	42	0.05	0.05	NUM
finefocus-3321	42	43	)	)	PUNCT
finefocus-3321	42	44	.	.	PUNCT
finefocus-3321	43	1	error	error	NOUN
finefocus-3321	43	2	bars	bar	NOUN
finefocus-3321	43	3	represent	represent	VERB
finefocus-3321	43	4	standard	standard	ADJ
finefocus-3321	43	5	error	error	NOUN
finefocus-3321	43	6	of	of	ADP
finefocus-3321	43	7	the	the	DET
finefocus-3321	43	8	mean	mean	NOUN
finefocus-3321	43	9	.	.	PUNCT
finefocus-3321	44	1	80	80	NUM
finefocus-3321	44	2	|	|	CCONJ
finefocus-3321	44	3	fine	fine	ADJ
finefocus-3321	44	4	focus	focus	NOUN
finefocus-3321	44	5	students	student	NOUN
finefocus-3321	44	6	in	in	ADP
finefocus-3321	44	7	the	the	DET
finefocus-3321	44	8	methods	method	NOUN
finefocus-3321	44	9	in	in	ADP
finefocus-3321	44	10	cell	cell	NOUN
finefocus-3321	44	11	biology	biology	NOUN
finefocus-3321	44	12	(	(	PUNCT
finefocus-3321	44	13	bio	bio	NOUN
finefocus-3321	44	14	315	315	NUM
finefocus-3321	44	15	)	)	PUNCT
finefocus-3321	44	16	course	course	NOUN
finefocus-3321	44	17	at	at	ADP
finefocus-3321	44	18	ball	ball	NOUN
finefocus-3321	44	19	state	state	PROPN
finefocus-3321	44	20	university	university	PROPN
finefocus-3321	44	21	and	and	CCONJ
finefocus-3321	44	22	has	have	AUX
finefocus-3321	44	23	been	be	AUX
finefocus-3321	44	24	validated	validate	VERB
finefocus-3321	44	25	by	by	ADP
finefocus-3321	44	26	three	three	NUM
finefocus-3321	44	27	replicates	replicate	NOUN
finefocus-3321	44	28	in	in	ADP
finefocus-3321	44	29	the	the	DET
finefocus-3321	44	30	research	research	NOUN
finefocus-3321	44	31	laboratories	laboratory	NOUN
finefocus-3321	44	32	of	of	ADP
finefocus-3321	44	33	emr	emr	PROPN
finefocus-3321	44	34	and	and	CCONJ
finefocus-3321	44	35	pjs	pjs	NOUN
finefocus-3321	44	36	.	.	PUNCT
finefocus-3321	45	1	discussion	discussion	NOUN
finefocus-3321	45	2	as	as	SCONJ
finefocus-3321	45	3	we	we	PRON
finefocus-3321	45	4	hypothesized	hypothesize	VERB
finefocus-3321	45	5	,	,	PUNCT
finefocus-3321	45	6	our	our	PRON
finefocus-3321	45	7	results	result	NOUN
finefocus-3321	45	8	indicate	indicate	VERB
finefocus-3321	45	9	ubr1	ubr1	PROPN
finefocus-3321	45	10	is	be	AUX
finefocus-3321	45	11	crucial	crucial	ADJ
finefocus-3321	45	12	for	for	ADP
finefocus-3321	45	13	optimal	optimal	ADJ
finefocus-3321	45	14	growth	growth	NOUN
finefocus-3321	45	15	of	of	ADP
finefocus-3321	45	16	yeast	yeast	NOUN
finefocus-3321	45	17	in	in	ADP
finefocus-3321	45	18	conditions	condition	NOUN
finefocus-3321	45	19	associated	associate	VERB
finefocus-3321	45	20	with	with	ADP
finefocus-3321	45	21	elevated	elevated	ADJ
finefocus-3321	45	22	abundance	abundance	NOUN
finefocus-3321	45	23	of	of	ADP
finefocus-3321	45	24	aberrant	aberrant	ADJ
finefocus-3321	45	25	proteins	protein	NOUN
finefocus-3321	45	26	,	,	PUNCT
finefocus-3321	45	27	consistent	consistent	ADJ
finefocus-3321	45	28	with	with	ADP
finefocus-3321	45	29	ubr1	ubr1	PROPN
finefocus-3321	45	30	function	function	NOUN
finefocus-3321	45	31	in	in	ADP
finefocus-3321	45	32	protein	protein	NOUN
finefocus-3321	45	33	quality	quality	NOUN
finefocus-3321	45	34	control	control	NOUN
finefocus-3321	45	35	.	.	PUNCT
finefocus-3321	46	1	mutations	mutation	NOUN
finefocus-3321	46	2	in	in	ADP
finefocus-3321	46	3	ubr1	ubr1	PROPN
finefocus-3321	46	4	are	be	AUX
finefocus-3321	46	5	found	find	VERB
finefocus-3321	46	6	in	in	ADP
finefocus-3321	46	7	patients	patient	NOUN
finefocus-3321	46	8	with	with	ADP
finefocus-3321	46	9	johanson	johanson	PROPN
finefocus-3321	46	10	-	-	PUNCT
finefocus-3321	46	11	blizzard	blizzard	NOUN
finefocus-3321	46	12	syndrome	syndrome	NOUN
finefocus-3321	46	13	.	.	PUNCT
finefocus-3321	47	1	a	a	DET
finefocus-3321	47	2	previous	previous	ADJ
finefocus-3321	47	3	study	study	NOUN
finefocus-3321	47	4	demonstrated	demonstrate	VERB
finefocus-3321	47	5	that	that	SCONJ
finefocus-3321	47	6	homologous	homologous	ADJ
finefocus-3321	47	7	mutations	mutation	NOUN
finefocus-3321	47	8	also	also	ADV
finefocus-3321	47	9	reduce	reduce	VERB
finefocus-3321	47	10	ubr1	ubr1	PROPN
finefocus-3321	47	11	function	function	NOUN
finefocus-3321	47	12	in	in	ADP
finefocus-3321	47	13	yeast	yeast	NOUN
finefocus-3321	47	14	(	(	PUNCT
finefocus-3321	47	15	8)	8)	NUM
finefocus-3321	47	16	.	.	PUNCT
finefocus-3321	48	1	we	we	PRON
finefocus-3321	48	2	speculate	speculate	VERB
finefocus-3321	48	3	that	that	SCONJ
finefocus-3321	48	4	disease	disease	NOUN
finefocus-3321	48	5	phenotypes	phenotype	NOUN
finefocus-3321	48	6	present	present	ADJ
finefocus-3321	48	7	in	in	ADP
finefocus-3321	48	8	patients	patient	NOUN
finefocus-3321	48	9	with	with	ADP
finefocus-3321	48	10	johansonblizzard	johansonblizzard	ADJ
finefocus-3321	48	11	syndrome	syndrome	NOUN
finefocus-3321	48	12	harboring	harboring	NOUN
finefocus-3321	48	13	mutations	mutation	NOUN
finefocus-3321	48	14	in	in	ADP
finefocus-3321	48	15	ubr1	ubr1	PROPN
finefocus-3321	48	16	are	be	AUX
finefocus-3321	48	17	linked	link	VERB
finefocus-3321	48	18	,	,	PUNCT
finefocus-3321	48	19	at	at	ADP
finefocus-3321	48	20	least	least	ADJ
finefocus-3321	48	21	in	in	ADP
finefocus-3321	48	22	part	part	NOUN
finefocus-3321	48	23	,	,	PUNCT
finefocus-3321	48	24	to	to	ADP
finefocus-3321	48	25	defects	defect	NOUN
finefocus-3321	48	26	in	in	ADP
finefocus-3321	48	27	protein	protein	NOUN
finefocus-3321	48	28	quality	quality	NOUN
finefocus-3321	48	29	control	control	NOUN
finefocus-3321	48	30	.	.	PUNCT
finefocus-3321	49	1	one	one	NUM
finefocus-3321	49	2	limitation	limitation	NOUN
finefocus-3321	49	3	of	of	ADP
finefocus-3321	49	4	the	the	DET
finefocus-3321	49	5	present	present	ADJ
finefocus-3321	49	6	work	work	NOUN
finefocus-3321	49	7	is	be	AUX
finefocus-3321	49	8	that	that	SCONJ
finefocus-3321	49	9	hygromycin	hygromycin	PROPN
finefocus-3321	49	10	b	b	PROPN
finefocus-3321	49	11	is	be	AUX
finefocus-3321	49	12	expected	expect	VERB
finefocus-3321	49	13	to	to	PART
finefocus-3321	49	14	trigger	trigger	VERB
finefocus-3321	49	15	the	the	DET
finefocus-3321	49	16	accumulation	accumulation	NOUN
finefocus-3321	49	17	of	of	ADP
finefocus-3321	49	18	a	a	DET
finefocus-3321	49	19	large	large	ADJ
finefocus-3321	49	20	and	and	CCONJ
finefocus-3321	49	21	heterogeneous	heterogeneous	ADJ
finefocus-3321	49	22	population	population	NOUN
finefocus-3321	49	23	of	of	ADP
finefocus-3321	49	24	aberrant	aberrant	ADJ
finefocus-3321	49	25	proteins	protein	NOUN
finefocus-3321	49	26	.	.	PUNCT
finefocus-3321	50	1	therefore	therefore	ADV
finefocus-3321	50	2	,	,	PUNCT
finefocus-3321	50	3	it	it	PRON
finefocus-3321	50	4	is	be	AUX
finefocus-3321	50	5	difficult	difficult	ADJ
finefocus-3321	50	6	to	to	PART
finefocus-3321	50	7	determine	determine	VERB
finefocus-3321	50	8	which	which	DET
finefocus-3321	50	9	types	type	NOUN
finefocus-3321	50	10	of	of	ADP
finefocus-3321	50	11	protein	protein	NOUN
finefocus-3321	50	12	aberrancies	aberrancy	NOUN
finefocus-3321	50	13	present	present	VERB
finefocus-3321	50	14	the	the	DET
finefocus-3321	50	15	most	most	ADV
finefocus-3321	50	16	substantial	substantial	ADJ
finefocus-3321	50	17	challenge	challenge	NOUN
finefocus-3321	50	18	to	to	ADP
finefocus-3321	50	19	cellular	cellular	ADJ
finefocus-3321	50	20	health	health	NOUN
finefocus-3321	50	21	in	in	ADP
finefocus-3321	50	22	the	the	DET
finefocus-3321	50	23	absence	absence	NOUN
finefocus-3321	50	24	of	of	ADP
finefocus-3321	50	25	ubr1	ubr1	PROPN
finefocus-3321	50	26	.	.	PUNCT
finefocus-3321	51	1	future	future	ADJ
finefocus-3321	51	2	biochemical	biochemical	ADJ
finefocus-3321	51	3	experiments	experiment	NOUN
finefocus-3321	51	4	will	will	AUX
finefocus-3321	51	5	be	be	AUX
finefocus-3321	51	6	necessary	necessary	ADJ
finefocus-3321	51	7	to	to	PART
finefocus-3321	51	8	characterize	characterize	VERB
finefocus-3321	51	9	the	the	DET
finefocus-3321	51	10	substrate	substrate	NOUN
finefocus-3321	51	11	range	range	NOUN
finefocus-3321	51	12	of	of	ADP
finefocus-3321	51	13	ubr1	ubr1	PROPN
finefocus-3321	51	14	in	in	ADP
finefocus-3321	51	15	yeast	yeast	NOUN
finefocus-3321	51	16	and	and	CCONJ
finefocus-3321	51	17	human	human	ADJ
finefocus-3321	51	18	cells	cell	NOUN
finefocus-3321	51	19	.	.	PUNCT
finefocus-3321	52	1	such	such	ADJ
finefocus-3321	52	2	biochemical	biochemical	ADJ
finefocus-3321	52	3	analyses	analysis	NOUN
finefocus-3321	52	4	may	may	AUX
finefocus-3321	52	5	also	also	ADV
finefocus-3321	52	6	provide	provide	VERB
finefocus-3321	52	7	insight	insight	NOUN
finefocus-3321	52	8	into	into	ADP
finefocus-3321	52	9	the	the	DET
finefocus-3321	52	10	divergent	divergent	ADJ
finefocus-3321	52	11	responses	response	NOUN
finefocus-3321	52	12	of	of	ADP
finefocus-3321	52	13	ubr1∆	ubr1∆	VERB
finefocus-3321	52	14	yeast	yeast	NOUN
finefocus-3321	52	15	to	to	ADP
finefocus-3321	52	16	different	different	ADJ
finefocus-3321	52	17	forms	form	NOUN
finefocus-3321	52	18	of	of	ADP
finefocus-3321	52	19	cellular	cellular	ADJ
finefocus-3321	52	20	stress	stress	NOUN
finefocus-3321	52	21	.	.	PUNCT
finefocus-3321	53	1	acknowledgements	acknowledgement	NOUN
finefocus-3321	53	2	this	this	DET
finefocus-3321	53	3	work	work	NOUN
finefocus-3321	53	4	was	be	AUX
finefocus-3321	53	5	funded	fund	VERB
finefocus-3321	53	6	by	by	ADP
finefocus-3321	53	7	nih	nih	PROPN
finefocus-3321	53	8	grant	grant	PROPN
finefocus-3321	53	9	r15	r15	PROPN
finefocus-3321	53	10	gm111713	gm111713	PROPN
finefocus-3321	53	11	(	(	PUNCT
finefocus-3321	53	12	emr	emr	PROPN
finefocus-3321	53	13	)	)	PUNCT
finefocus-3321	53	14	.	.	PUNCT
finefocus-3321	54	1	this	this	DET
finefocus-3321	54	2	project	project	NOUN
finefocus-3321	54	3	was	be	AUX
finefocus-3321	54	4	conceived	conceive	VERB
finefocus-3321	54	5	while	while	SCONJ
finefocus-3321	54	6	emr	emr	PROPN
finefocus-3321	54	7	was	be	AUX
finefocus-3321	54	8	supported	support	VERB
finefocus-3321	54	9	in	in	ADP
finefocus-3321	54	10	part	part	NOUN
finefocus-3321	54	11	by	by	ADP
finefocus-3321	54	12	a	a	DET
finefocus-3321	54	13	ball	ball	NOUN
finefocus-3321	54	14	state	state	PROPN
finefocus-3321	54	15	university	university	PROPN
finefocus-3321	54	16	excellence	excellence	NOUN
finefocus-3321	54	17	in	in	ADP
finefocus-3321	54	18	teaching	teaching	NOUN
finefocus-3321	54	19	award	award	NOUN
finefocus-3321	54	20	.	.	PUNCT
finefocus-3321	55	1	research	research	NOUN
finefocus-3321	55	2	in	in	ADP
finefocus-3321	55	3	the	the	DET
finefocus-3321	55	4	lab	lab	NOUN
finefocus-3321	55	5	of	of	ADP
finefocus-3321	55	6	pjs	pjs	NOUN
finefocus-3321	55	7	is	be	AUX
finefocus-3321	55	8	supported	support	VERB
finefocus-3321	55	9	by	by	ADP
finefocus-3321	55	10	grant	grant	PROPN
finefocus-3321	55	11	18	18	NUM
finefocus-3321	55	12	-	-	PUNCT
finefocus-3321	55	13	iia-406	iia-406	NOUN
finefocus-3321	55	14	from	from	ADP
finefocus-3321	55	15	the	the	DET
finefocus-3321	55	16	amyotrophic	amyotrophic	ADJ
finefocus-3321	55	17	lateral	lateral	ADJ
finefocus-3321	55	18	sclerosis	sclerosis	NOUN
finefocus-3321	55	19	association	association	PROPN
finefocus-3321	55	20	.	.	PUNCT
finefocus-3321	56	1	we	we	PRON
finefocus-3321	56	2	thank	thank	VERB
finefocus-3321	56	3	the	the	DET
finefocus-3321	56	4	ball	ball	NOUN
finefocus-3321	56	5	state	state	PROPN
finefocus-3321	56	6	university	university	PROPN
finefocus-3321	56	7	department	department	NOUN
finefocus-3321	56	8	of	of	ADP
finefocus-3321	56	9	biology	biology	NOUN
finefocus-3321	56	10	(	(	PUNCT
finefocus-3321	56	11	particularly	particularly	ADV
finefocus-3321	56	12	kemuel	kemuel	PROPN
finefocus-3321	56	13	badger	badger	PROPN
finefocus-3321	56	14	,	,	PUNCT
finefocus-3321	56	15	clare	clare	NOUN
finefocus-3321	56	16	chatot	chatot	NOUN
finefocus-3321	56	17	,	,	PUNCT
finefocus-3321	56	18	and	and	CCONJ
finefocus-3321	56	19	susan	susan	PROPN
finefocus-3321	56	20	mcdowell	mcdowell	PROPN
finefocus-3321	56	21	)	)	PUNCT
finefocus-3321	56	22	for	for	ADP
finefocus-3321	56	23	material	material	NOUN
finefocus-3321	56	24	and	and	CCONJ
finefocus-3321	56	25	moral	moral	ADJ
finefocus-3321	56	26	support	support	NOUN
finefocus-3321	56	27	for	for	ADP
finefocus-3321	56	28	the	the	DET
finefocus-3321	56	29	design	design	NOUN
finefocus-3321	56	30	and	and	CCONJ
finefocus-3321	56	31	implementation	implementation	NOUN
finefocus-3321	56	32	of	of	ADP
finefocus-3321	56	33	an	an	DET
finefocus-3321	56	34	inquiry	inquiry	NOUN
finefocus-3321	56	35	-	-	PUNCT
finefocus-3321	56	36	based	base	VERB
finefocus-3321	56	37	research	research	NOUN
finefocus-3321	56	38	course	course	NOUN
finefocus-3321	56	39	,	,	PUNCT
finefocus-3321	56	40	where	where	SCONJ
finefocus-3321	56	41	this	this	DET
finefocus-3321	56	42	experiment	experiment	NOUN
finefocus-3321	56	43	was	be	AUX
finefocus-3321	56	44	piloted	pilot	VERB
finefocus-3321	56	45	.	.	PUNCT
finefocus-3321	57	1	we	we	PRON
finefocus-3321	57	2	thank	thank	VERB
finefocus-3321	57	3	jacob	jacob	PROPN
finefocus-3321	57	4	price	price	NOUN
finefocus-3321	57	5	for	for	ADP
finefocus-3321	57	6	serving	serve	VERB
finefocus-3321	57	7	as	as	ADP
finefocus-3321	57	8	a	a	DET
finefocus-3321	57	9	teaching	teaching	NOUN
finefocus-3321	57	10	assistant	assistant	NOUN
finefocus-3321	57	11	in	in	ADP
finefocus-3321	57	12	that	that	DET
finefocus-3321	57	13	course	course	NOUN
finefocus-3321	57	14	.	.	PUNCT
finefocus-3321	58	1	we	we	PRON
finefocus-3321	58	2	thank	thank	VERB
finefocus-3321	58	3	bryce	bryce	PROPN
finefocus-3321	58	4	buchanan	buchanan	PROPN
finefocus-3321	58	5	and	and	CCONJ
finefocus-3321	58	6	courtney	courtney	PROPN
finefocus-3321	58	7	broshar	broshar	PROPN
finefocus-3321	58	8	for	for	ADP
finefocus-3321	58	9	technical	technical	ADJ
finefocus-3321	58	10	assistance	assistance	NOUN
finefocus-3321	58	11	.	.	PUNCT
finefocus-3321	59	1	volume	volume	NOUN
finefocus-3321	59	2	six	six	NUM
finefocus-3321	59	3	|	|	ADV
finefocus-3321	59	4	81	81	NUM
finefocus-3321	59	5	table	table	NOUN
finefocus-3321	59	6	1	1	NUM
finefocus-3321	59	7	.	.	PUNCT
finefocus-3321	59	8	yeast	yeast	NOUN
finefocus-3321	59	9	strains	strain	NOUN
finefocus-3321	59	10	used	use	VERB
finefocus-3321	59	11	in	in	ADP
finefocus-3321	59	12	this	this	DET
finefocus-3321	59	13	study	study	NOUN
finefocus-3321	59	14	.	.	PUNCT
finefocus-3321	60	1	all	all	DET
finefocus-3321	60	2	strains	strain	NOUN
finefocus-3321	60	3	used	use	VERB
finefocus-3321	60	4	in	in	ADP
finefocus-3321	60	5	this	this	DET
finefocus-3321	60	6	study	study	NOUN
finefocus-3321	60	7	are	be	AUX
finefocus-3321	60	8	congenic	congenic	ADJ
finefocus-3321	60	9	with	with	ADP
finefocus-3321	60	10	by4741	by4741	PROPN
finefocus-3321	60	11	(	(	PUNCT
finefocus-3321	60	12	16	16	NUM
finefocus-3321	60	13	)	)	PUNCT
finefocus-3321	60	14	.	.	PUNCT
finefocus-3321	61	1	82	82	NUM
finefocus-3321	62	1	|	|	CCONJ
finefocus-3321	62	2	fine	fine	ADJ
finefocus-3321	62	3	focus	focus	NOUN
finefocus-3321	62	4	references	reference	NOUN
finefocus-3321	62	5	1	1	NUM
finefocus-3321	62	6	.	.	X
finefocus-3321	62	7	brodersen	brodersen	PROPN
finefocus-3321	62	8	,	,	PUNCT
finefocus-3321	62	9	d.	d.	PROPN
finefocus-3321	62	10	e.	e.	PROPN
finefocus-3321	62	11	,	,	PUNCT
finefocus-3321	62	12	clemons	clemon	NOUN
finefocus-3321	62	13	,	,	PUNCT
finefocus-3321	62	14	w.	w.	PROPN
finefocus-3321	62	15	m.	m.	PROPN
finefocus-3321	62	16	,	,	PUNCT
finefocus-3321	62	17	jr	jr	PROPN
finefocus-3321	62	18	.	.	PROPN
finefocus-3321	62	19	,	,	PUNCT
finefocus-3321	62	20	carter	carter	PROPN
finefocus-3321	62	21	,	,	PUNCT
finefocus-3321	62	22	a.	a.	PROPN
finefocus-3321	62	23	p.	p.	PROPN
finefocus-3321	62	24	,	,	PUNCT
finefocus-3321	62	25	morgan	morgan	PROPN
finefocus-3321	62	26	-	-	PUNCT
finefocus-3321	62	27	warren	warren	PROPN
finefocus-3321	62	28	,	,	PUNCT
finefocus-3321	62	29	r.	r.	PROPN
finefocus-3321	62	30	j.	j.	PROPN
finefocus-3321	62	31	,	,	PUNCT
finefocus-3321	62	32	wimberly	wimberly	ADV
finefocus-3321	62	33	,	,	PUNCT
finefocus-3321	62	34	b.	b.	PROPN
finefocus-3321	62	35	t.	t.	PROPN
finefocus-3321	62	36	,	,	PUNCT
finefocus-3321	62	37	&	&	CCONJ
finefocus-3321	62	38	ramakrishnan	ramakrishnan	PROPN
finefocus-3321	62	39	,	,	PUNCT
finefocus-3321	62	40	v.	v.	PROPN
finefocus-3321	62	41	(	(	PUNCT
finefocus-3321	62	42	2000	2000	NUM
finefocus-3321	62	43	)	)	PUNCT
finefocus-3321	62	44	.	.	PUNCT
finefocus-3321	63	1	the	the	DET
finefocus-3321	63	2	structural	structural	ADJ
finefocus-3321	63	3	basis	basis	NOUN
finefocus-3321	63	4	for	for	ADP
finefocus-3321	63	5	the	the	DET
finefocus-3321	63	6	action	action	NOUN
finefocus-3321	63	7	of	of	ADP
finefocus-3321	63	8	the	the	DET
finefocus-3321	63	9	antibiotics	antibiotic	NOUN
finefocus-3321	63	10	tetracycline	tetracycline	NOUN
finefocus-3321	63	11	,	,	PUNCT
finefocus-3321	63	12	pactamycin	pactamycin	NOUN
finefocus-3321	63	13	,	,	PUNCT
finefocus-3321	63	14	and	and	CCONJ
finefocus-3321	63	15	hygromycin	hygromycin	PROPN
finefocus-3321	63	16	b	b	PROPN
finefocus-3321	63	17	on	on	ADP
finefocus-3321	63	18	the	the	DET
finefocus-3321	63	19	30s	30	NOUN
finefocus-3321	63	20	ribosomal	ribosomal	NOUN
finefocus-3321	63	21	subunit	subunit	NOUN
finefocus-3321	63	22	.	.	PUNCT
finefocus-3321	64	1	cell	cell	NOUN
finefocus-3321	64	2	,	,	PUNCT
finefocus-3321	64	3	103(7	103(7	NUM
finefocus-3321	64	4	)	)	PUNCT
finefocus-3321	64	5	,	,	PUNCT
finefocus-3321	64	6	1143	1143	NUM
finefocus-3321	64	7	-	-	SYM
finefocus-3321	64	8	1154	1154	NUM
finefocus-3321	64	9	.	.	PUNCT
finefocus-3321	65	1	https://www.cell.com/	https://www.cell.com/	PROPN
finefocus-3321	65	2	fulltext	fulltext	PROPN
finefocus-3321	65	3	/	/	SYM
finefocus-3321	65	4	s0092	s0092	PROPN
finefocus-3321	65	5	-	-	PUNCT
finefocus-3321	65	6	8674(00)00216	8674(00)00216	NUM
finefocus-3321	65	7	-	-	SYM
finefocus-3321	65	8	6	6	NUM
finefocus-3321	65	9	2	2	NUM
finefocus-3321	65	10	.	.	PUNCT
finefocus-3321	66	1	crowder	crowder	PROPN
finefocus-3321	66	2	,	,	PUNCT
finefocus-3321	66	3	j.	j.	PROPN
finefocus-3321	66	4	j.	j.	PROPN
finefocus-3321	66	5	,	,	PUNCT
finefocus-3321	66	6	geigges	geigge	NOUN
finefocus-3321	66	7	,	,	PUNCT
finefocus-3321	66	8	m.	m.	NOUN
finefocus-3321	66	9	,	,	PUNCT
finefocus-3321	66	10	gibson	gibson	PROPN
finefocus-3321	66	11	,	,	PUNCT
finefocus-3321	66	12	r.	r.	PROPN
finefocus-3321	66	13	t.	t.	PROPN
finefocus-3321	66	14	,	,	PUNCT
finefocus-3321	66	15	fults	fult	NOUN
finefocus-3321	66	16	,	,	PUNCT
finefocus-3321	66	17	e.	e.	PROPN
finefocus-3321	66	18	s.	s.	PROPN
finefocus-3321	66	19	,	,	PUNCT
finefocus-3321	66	20	buchanan	buchanan	PROPN
finefocus-3321	66	21	,	,	PUNCT
finefocus-3321	66	22	b.	b.	PROPN
finefocus-3321	66	23	w.	w.	PROPN
finefocus-3321	66	24	,	,	PUNCT
finefocus-3321	66	25	sachs	sachs	PROPN
finefocus-3321	66	26	,	,	PUNCT
finefocus-3321	66	27	n.	n.	NOUN
finefocus-3321	66	28	,	,	PUNCT
finefocus-3321	66	29	.	.	PUNCT
finefocus-3321	66	30	.	.	PUNCT
finefocus-3321	66	31	.	.	PUNCT
finefocus-3321	67	1	rubenstein	rubenstein	PROPN
finefocus-3321	67	2	,	,	PUNCT
finefocus-3321	67	3	e.	e.	PROPN
finefocus-3321	67	4	m.	m.	PROPN
finefocus-3321	67	5	(	(	PUNCT
finefocus-3321	67	6	2015	2015	NUM
finefocus-3321	67	7	)	)	PUNCT
finefocus-3321	67	8	.	.	PUNCT
finefocus-3321	68	1	rkr1	rkr1	PROPN
finefocus-3321	68	2	/	/	SYM
finefocus-3321	68	3	ltn1	ltn1	PROPN
finefocus-3321	68	4	ubiquitin	ubiquitin	NOUN
finefocus-3321	68	5	ligase	ligase	NOUN
finefocus-3321	68	6	-	-	PUNCT
finefocus-3321	68	7	mediated	mediate	VERB
finefocus-3321	68	8	degradation	degradation	NOUN
finefocus-3321	68	9	of	of	ADP
finefocus-3321	68	10	translationally	translationally	ADV
finefocus-3321	68	11	stalled	stall	VERB
finefocus-3321	68	12	endoplasmic	endoplasmic	ADJ
finefocus-3321	68	13	reticulum	reticulum	NOUN
finefocus-3321	68	14	proteins	protein	NOUN
finefocus-3321	68	15	.	.	PUNCT
finefocus-3321	69	1	j	j	PROPN
finefocus-3321	69	2	biol	biol	PROPN
finefocus-3321	69	3	chem	chem	NOUN
finefocus-3321	69	4	,	,	PUNCT
finefocus-3321	69	5	290(30	290(30	NUM
finefocus-3321	69	6	)	)	PUNCT
finefocus-3321	69	7	,	,	PUNCT
finefocus-3321	69	8	18454	18454	NUM
finefocus-3321	69	9	-	-	SYM
finefocus-3321	69	10	18466	18466	NUM
finefocus-3321	69	11	.	.	PUNCT
finefocus-3321	70	1	http://www.jbc.org/content/290/30/18454	http://www.jbc.org/content/290/30/18454	PROPN
finefocus-3321	70	2	.	.	PUNCT
finefocus-3321	70	3	full	full	ADJ
finefocus-3321	70	4	3	3	PROPN
finefocus-3321	70	5	.	.	PUNCT
finefocus-3321	70	6	finley	finley	PROPN
finefocus-3321	70	7	,	,	PUNCT
finefocus-3321	70	8	d.	d.	PROPN
finefocus-3321	70	9	,	,	PUNCT
finefocus-3321	70	10	ulrich	ulrich	PROPN
finefocus-3321	70	11	,	,	PUNCT
finefocus-3321	70	12	h.	h.	PROPN
finefocus-3321	70	13	d.	d.	PROPN
finefocus-3321	70	14	,	,	PUNCT
finefocus-3321	70	15	sommer	sommer	NOUN
finefocus-3321	70	16	,	,	PUNCT
finefocus-3321	70	17	t.	t.	PROPN
finefocus-3321	70	18	,	,	PUNCT
finefocus-3321	70	19	&	&	CCONJ
finefocus-3321	70	20	kaiser	kaiser	PROPN
finefocus-3321	70	21	,	,	PUNCT
finefocus-3321	70	22	p.	p.	NOUN
finefocus-3321	70	23	(	(	PUNCT
finefocus-3321	70	24	2012	2012	NUM
finefocus-3321	70	25	)	)	PUNCT
finefocus-3321	70	26	.	.	PUNCT
finefocus-3321	71	1	the	the	DET
finefocus-3321	71	2	ubiquitin	ubiquitin	ADJ
finefocus-3321	71	3	-	-	PUNCT
finefocus-3321	71	4	proteasome	proteasome	NOUN
finefocus-3321	71	5	system	system	NOUN
finefocus-3321	71	6	of	of	ADP
finefocus-3321	71	7	saccharomyces	saccharomyce	NOUN
finefocus-3321	71	8	cerevisiae	cerevisiae	NOUN
finefocus-3321	71	9	.	.	PUNCT
finefocus-3321	72	1	genetics	genetic	NOUN
finefocus-3321	72	2	,	,	PUNCT
finefocus-3321	72	3	192(2	192(2	NUM
finefocus-3321	72	4	)	)	PUNCT
finefocus-3321	72	5	,	,	PUNCT
finefocus-3321	72	6	319	319	NUM
finefocus-3321	72	7	-	-	SYM
finefocus-3321	72	8	360	360	NUM
finefocus-3321	72	9	.	.	PUNCT
finefocus-3321	73	1	https://www.genetics.org/content/192/2/319.full	https://www.genetics.org/content/192/2/319.full	PROPN
finefocus-3321	73	2	4	4	PROPN
finefocus-3321	73	3	.	.	PUNCT
finefocus-3321	73	4	ganoza	ganoza	PROPN
finefocus-3321	73	5	,	,	PUNCT
finefocus-3321	73	6	m.	m.	PROPN
finefocus-3321	73	7	c.	c.	PROPN
finefocus-3321	73	8	,	,	PUNCT
finefocus-3321	73	9	&	&	CCONJ
finefocus-3321	73	10	kiel	kiel	PROPN
finefocus-3321	73	11	,	,	PUNCT
finefocus-3321	73	12	m.	m.	PROPN
finefocus-3321	73	13	c.	c.	PROPN
finefocus-3321	73	14	(	(	PUNCT
finefocus-3321	73	15	2001	2001	NUM
finefocus-3321	73	16	)	)	PUNCT
finefocus-3321	73	17	.	.	PUNCT
finefocus-3321	74	1	a	a	DET
finefocus-3321	74	2	ribosomal	ribosomal	NOUN
finefocus-3321	74	3	atpase	atpase	NOUN
finefocus-3321	74	4	is	be	AUX
finefocus-3321	74	5	a	a	DET
finefocus-3321	74	6	target	target	NOUN
finefocus-3321	74	7	for	for	ADP
finefocus-3321	74	8	hygromycin	hygromycin	NOUN
finefocus-3321	74	9	b	b	NOUN
finefocus-3321	74	10	inhibition	inhibition	NOUN
finefocus-3321	74	11	on	on	ADP
finefocus-3321	74	12	escherichia	escherichia	NOUN
finefocus-3321	74	13	coli	coli	NOUN
finefocus-3321	74	14	ribosomes	ribosome	NOUN
finefocus-3321	74	15	.	.	PUNCT
finefocus-3321	75	1	antimicrob	antimicrob	PROPN
finefocus-3321	75	2	agents	agents	PROPN
finefocus-3321	75	3	chemother	chemother	PROPN
finefocus-3321	75	4	,	,	PUNCT
finefocus-3321	75	5	45(10	45(10	NUM
finefocus-3321	75	6	)	)	PUNCT
finefocus-3321	75	7	,	,	PUNCT
finefocus-3321	75	8	2813	2813	NUM
finefocus-3321	75	9	-	-	SYM
finefocus-3321	75	10	2819	2819	NUM
finefocus-3321	75	11	.	.	PUNCT
finefocus-3321	76	1	https://aac.asm.org/	https://aac.asm.org/	NOUN
finefocus-3321	76	2	content/45/10/2813	content/45/10/2813	NOUN
finefocus-3321	76	3	5	5	NUM
finefocus-3321	76	4	.	.	PUNCT
finefocus-3321	77	1	guthrie	guthrie	PROPN
finefocus-3321	77	2	,	,	PUNCT
finefocus-3321	77	3	c.	c.	PROPN
finefocus-3321	77	4	,	,	PUNCT
finefocus-3321	77	5	&	&	CCONJ
finefocus-3321	77	6	fink	fink	PROPN
finefocus-3321	77	7	,	,	PUNCT
finefocus-3321	77	8	g.	g.	PROPN
finefocus-3321	77	9	r.	r.	PROPN
finefocus-3321	77	10	(	(	PUNCT
finefocus-3321	77	11	2004	2004	NUM
finefocus-3321	77	12	)	)	PUNCT
finefocus-3321	77	13	.	.	PUNCT
finefocus-3321	78	1	guide	guide	VERB
finefocus-3321	78	2	to	to	ADP
finefocus-3321	78	3	yeast	yeast	NOUN
finefocus-3321	78	4	genetics	genetic	NOUN
finefocus-3321	78	5	and	and	CCONJ
finefocus-3321	78	6	molecular	molecular	ADJ
finefocus-3321	78	7	and	and	CCONJ
finefocus-3321	78	8	cell	cell	NOUN
finefocus-3321	78	9	biology	biology	NOUN
finefocus-3321	78	10	.	.	PUNCT
finefocus-3321	79	1	san	san	PROPN
finefocus-3321	79	2	diego	diego	PROPN
finefocus-3321	79	3	:	:	PUNCT
finefocus-3321	79	4	elsevier	elsevier	NOUN
finefocus-3321	79	5	.	.	PUNCT
finefocus-3321	80	1	6	6	NUM
finefocus-3321	80	2	.	.	X
finefocus-3321	80	3	habeck	habeck	PROPN
finefocus-3321	80	4	,	,	PUNCT
finefocus-3321	80	5	g.	g.	PROPN
finefocus-3321	80	6	,	,	PUNCT
finefocus-3321	80	7	ebner	ebner	PROPN
finefocus-3321	80	8	,	,	PUNCT
finefocus-3321	80	9	f.	f.	PROPN
finefocus-3321	80	10	a.	a.	PROPN
finefocus-3321	80	11	,	,	PUNCT
finefocus-3321	80	12	shimada	shimada	PROPN
finefocus-3321	80	13	-	-	PUNCT
finefocus-3321	80	14	kreft	kreft	PROPN
finefocus-3321	80	15	,	,	PUNCT
finefocus-3321	80	16	h.	h.	PROPN
finefocus-3321	80	17	,	,	PUNCT
finefocus-3321	80	18	&	&	CCONJ
finefocus-3321	80	19	kreft	kreft	PROPN
finefocus-3321	80	20	,	,	PUNCT
finefocus-3321	80	21	s.	s.	PROPN
finefocus-3321	80	22	g.	g.	PROPN
finefocus-3321	80	23	(	(	PUNCT
finefocus-3321	80	24	2015	2015	NUM
finefocus-3321	80	25	)	)	PUNCT
finefocus-3321	80	26	.	.	PUNCT
finefocus-3321	81	1	the	the	DET
finefocus-3321	81	2	yeast	yeast	NOUN
finefocus-3321	81	3	erad	erad	ADJ
finefocus-3321	81	4	-	-	PUNCT
finefocus-3321	81	5	c	c	NOUN
finefocus-3321	81	6	ubiquitin	ubiquitin	NOUN
finefocus-3321	81	7	ligase	ligase	NOUN
finefocus-3321	81	8	doa10	doa10	PROPN
finefocus-3321	81	9	recognizes	recognize	VERB
finefocus-3321	81	10	an	an	DET
finefocus-3321	81	11	intramembrane	intramembrane	NOUN
finefocus-3321	81	12	degron	degron	NOUN
finefocus-3321	81	13	.	.	PUNCT
finefocus-3321	82	1	j	j	PROPN
finefocus-3321	82	2	cell	cell	PROPN
finefocus-3321	82	3	biol	biol	PROPN
finefocus-3321	82	4	,	,	PUNCT
finefocus-3321	82	5	209(2	209(2	NUM
finefocus-3321	82	6	)	)	PUNCT
finefocus-3321	82	7	,	,	PUNCT
finefocus-3321	82	8	261	261	NUM
finefocus-3321	82	9	-	-	SYM
finefocus-3321	82	10	273	273	NUM
finefocus-3321	82	11	.	.	PUNCT
finefocus-3321	83	1	http://jcb.rupress.org/	http://jcb.rupress.org/	PROPN
finefocus-3321	83	2	content/209/2/261.long	content/209/2/261.long	PROPN
finefocus-3321	84	1	7	7	X
finefocus-3321	84	2	.	.	X
finefocus-3321	84	3	heck	heck	INTJ
finefocus-3321	84	4	,	,	PUNCT
finefocus-3321	84	5	j.	j.	PROPN
finefocus-3321	84	6	w.	w.	PROPN
finefocus-3321	84	7	,	,	PUNCT
finefocus-3321	84	8	cheung	cheung	PROPN
finefocus-3321	84	9	,	,	PUNCT
finefocus-3321	84	10	s.	s.	PROPN
finefocus-3321	84	11	k.	k.	PROPN
finefocus-3321	84	12	,	,	PUNCT
finefocus-3321	84	13	&	&	CCONJ
finefocus-3321	84	14	hampton	hampton	PROPN
finefocus-3321	84	15	,	,	PUNCT
finefocus-3321	84	16	r.	r.	PROPN
finefocus-3321	84	17	y.	y.	PROPN
finefocus-3321	84	18	(	(	PUNCT
finefocus-3321	84	19	2010	2010	NUM
finefocus-3321	84	20	)	)	PUNCT
finefocus-3321	84	21	.	.	PUNCT
finefocus-3321	85	1	cytoplasmic	cytoplasmic	ADJ
finefocus-3321	85	2	protein	protein	NOUN
finefocus-3321	85	3	quality	quality	NOUN
finefocus-3321	85	4	control	control	NOUN
finefocus-3321	85	5	degradation	degradation	NOUN
finefocus-3321	85	6	mediated	mediate	VERB
finefocus-3321	85	7	by	by	ADP
finefocus-3321	85	8	parallel	parallel	ADJ
finefocus-3321	85	9	actions	action	NOUN
finefocus-3321	85	10	of	of	ADP
finefocus-3321	85	11	the	the	DET
finefocus-3321	85	12	e3	e3	NOUN
finefocus-3321	85	13	ubiquitin	ubiquitin	NOUN
finefocus-3321	85	14	ligases	ligase	NOUN
finefocus-3321	85	15	ubr1	ubr1	PROPN
finefocus-3321	85	16	and	and	CCONJ
finefocus-3321	85	17	san1	san1	PROPN
finefocus-3321	85	18	.	.	PUNCT
finefocus-3321	86	1	proc	proc	PROPN
finefocus-3321	86	2	natl	natl	PROPN
finefocus-3321	86	3	acad	acad	PROPN
finefocus-3321	86	4	sci	sci	PROPN
finefocus-3321	86	5	u	u	PROPN
finefocus-3321	86	6	s	s	PROPN
finefocus-3321	86	7	a	a	PRON
finefocus-3321	86	8	,	,	PUNCT
finefocus-3321	86	9	107(3	107(3	NUM
finefocus-3321	86	10	)	)	PUNCT
finefocus-3321	86	11	,	,	PUNCT
finefocus-3321	86	12	1106	1106	NUM
finefocus-3321	86	13	-	-	SYM
finefocus-3321	86	14	1111	1111	NUM
finefocus-3321	86	15	.	.	PUNCT
finefocus-3321	87	1	https://www.pnas.org/content/107/3/1106	https://www.pnas.org/content/107/3/1106	PRON
finefocus-3321	87	2	8	8	NUM
finefocus-3321	87	3	.	.	X
finefocus-3321	88	1	hwang	hwang	PROPN
finefocus-3321	88	2	,	,	PUNCT
finefocus-3321	88	3	c.	c.	PROPN
finefocus-3321	88	4	s.	s.	PROPN
finefocus-3321	88	5	,	,	PUNCT
finefocus-3321	88	6	sukalo	sukalo	PROPN
finefocus-3321	88	7	,	,	PUNCT
finefocus-3321	88	8	m.	m.	NOUN
finefocus-3321	88	9	,	,	PUNCT
finefocus-3321	88	10	batygin	batygin	NOUN
finefocus-3321	88	11	,	,	PUNCT
finefocus-3321	88	12	o.	o.	PROPN
finefocus-3321	88	13	,	,	PUNCT
finefocus-3321	88	14	addor	addor	NOUN
finefocus-3321	88	15	,	,	PUNCT
finefocus-3321	88	16	m.	m.	PROPN
finefocus-3321	88	17	c.	c.	PROPN
finefocus-3321	88	18	,	,	PUNCT
finefocus-3321	88	19	brunner	brunner	PROPN
finefocus-3321	88	20	,	,	PUNCT
finefocus-3321	88	21	h.	h.	PROPN
finefocus-3321	88	22	,	,	PUNCT
finefocus-3321	88	23	aytes	ayte	VERB
finefocus-3321	88	24	,	,	PUNCT
finefocus-3321	88	25	.	.	PUNCT
finefocus-3321	88	26	.	.	PUNCT
finefocus-3321	88	27	.	.	PUNCT
finefocus-3321	89	1	zenker	zenker	NOUN
finefocus-3321	89	2	,	,	PUNCT
finefocus-3321	89	3	m.	m.	NOUN
finefocus-3321	89	4	(	(	PUNCT
finefocus-3321	89	5	2011	2011	NUM
finefocus-3321	89	6	)	)	PUNCT
finefocus-3321	89	7	.	.	PUNCT
finefocus-3321	90	1	ubiquitin	ubiquitin	ADJ
finefocus-3321	90	2	ligases	ligase	NOUN
finefocus-3321	90	3	of	of	ADP
finefocus-3321	90	4	the	the	DET
finefocus-3321	90	5	n	n	CCONJ
finefocus-3321	90	6	-	-	PUNCT
finefocus-3321	90	7	end	end	NOUN
finefocus-3321	90	8	rule	rule	NOUN
finefocus-3321	90	9	pathway	pathway	NOUN
finefocus-3321	90	10	:	:	PUNCT
finefocus-3321	90	11	assessment	assessment	NOUN
finefocus-3321	90	12	of	of	ADP
finefocus-3321	90	13	mutations	mutation	NOUN
finefocus-3321	90	14	in	in	ADP
finefocus-3321	90	15	ubr1	ubr1	PROPN
finefocus-3321	90	16	that	that	PRON
finefocus-3321	90	17	cause	cause	VERB
finefocus-3321	90	18	the	the	DET
finefocus-3321	90	19	johanson	johanson	PROPN
finefocus-3321	90	20	-	-	PUNCT
finefocus-3321	90	21	blizzard	blizzard	NOUN
finefocus-3321	90	22	syndrome	syndrome	NOUN
finefocus-3321	90	23	.	.	PUNCT
finefocus-3321	91	1	plos	plos	PROPN
finefocus-3321	91	2	one	one	NUM
finefocus-3321	91	3	,	,	PUNCT
finefocus-3321	91	4	6(9	6(9	NUM
finefocus-3321	91	5	)	)	PUNCT
finefocus-3321	91	6	,	,	PUNCT
finefocus-3321	91	7	e24925	e24925	PROPN
finefocus-3321	91	8	.	.	NOUN
finefocus-3321	91	9	https://journals.plos.org/plosone/	https://journals.plos.org/plosone/	NOUN
finefocus-3321	91	10	article?id=10.1371	article?id=10.1371	NOUN
finefocus-3321	91	11	/	/	SYM
finefocus-3321	91	12	journal.pone.0024925	journal.pone.0024925	ADJ
finefocus-3321	91	13	9	9	NUM
finefocus-3321	91	14	.	.	PUNCT
finefocus-3321	91	15	kaster	kaster	NOUN
finefocus-3321	91	16	,	,	PUNCT
finefocus-3321	91	17	k.	k.	PROPN
finefocus-3321	91	18	r.	r.	PROPN
finefocus-3321	91	19	,	,	PUNCT
finefocus-3321	91	20	burgett	burgett	PROPN
finefocus-3321	91	21	,	,	PUNCT
finefocus-3321	91	22	s.	s.	PROPN
finefocus-3321	91	23	g.	g.	PROPN
finefocus-3321	91	24	,	,	PUNCT
finefocus-3321	91	25	&	&	CCONJ
finefocus-3321	91	26	ingolia	ingolia	PROPN
finefocus-3321	91	27	,	,	PUNCT
finefocus-3321	91	28	t.	t.	PROPN
finefocus-3321	91	29	d.	d.	PROPN
finefocus-3321	91	30	(	(	PUNCT
finefocus-3321	91	31	1984	1984	NUM
finefocus-3321	91	32	)	)	PUNCT
finefocus-3321	91	33	.	.	PUNCT
finefocus-3321	92	1	hygromycin	hygromycin	PROPN
finefocus-3321	92	2	b	b	PROPN
finefocus-3321	92	3	resistance	resistance	NOUN
finefocus-3321	92	4	as	as	ADP
finefocus-3321	92	5	dominant	dominant	ADJ
finefocus-3321	92	6	selectable	selectable	ADJ
finefocus-3321	92	7	marker	marker	NOUN
finefocus-3321	92	8	in	in	ADP
finefocus-3321	92	9	yeast	yeast	NOUN
finefocus-3321	92	10	.	.	PUNCT
finefocus-3321	93	1	curr	curr	PROPN
finefocus-3321	93	2	genet	genet	PROPN
finefocus-3321	93	3	,	,	PUNCT
finefocus-3321	93	4	8(5	8(5	NUM
finefocus-3321	93	5	)	)	PUNCT
finefocus-3321	93	6	,	,	PUNCT
finefocus-3321	93	7	353	353	NUM
finefocus-3321	93	8	-	-	SYM
finefocus-3321	93	9	358	358	NUM
finefocus-3321	93	10	.	.	PUNCT
finefocus-3321	94	1	https://link.springer.com/article/10.1007/bf00419824	https://link.springer.com/article/10.1007/bf00419824	NUM
finefocus-3321	94	2	10	10	NUM
finefocus-3321	94	3	.	.	PUNCT
finefocus-3321	95	1	mehrtash	mehrtash	PROPN
finefocus-3321	95	2	,	,	PUNCT
finefocus-3321	95	3	a.	a.	PROPN
finefocus-3321	95	4	b.	b.	PROPN
finefocus-3321	95	5	,	,	PUNCT
finefocus-3321	95	6	&	&	CCONJ
finefocus-3321	95	7	hochstrasser	hochstrasser	PROPN
finefocus-3321	95	8	,	,	PUNCT
finefocus-3321	95	9	m.	m.	NOUN
finefocus-3321	95	10	(	(	PUNCT
finefocus-3321	95	11	2018	2018	NUM
finefocus-3321	95	12	)	)	PUNCT
finefocus-3321	95	13	.	.	PUNCT
finefocus-3321	96	1	ubiquitin	ubiquitin	ADJ
finefocus-3321	96	2	-	-	PUNCT
finefocus-3321	96	3	dependent	dependent	ADJ
finefocus-3321	96	4	protein	protein	NOUN
finefocus-3321	96	5	degradation	degradation	NOUN
finefocus-3321	96	6	at	at	ADP
finefocus-3321	96	7	the	the	DET
finefocus-3321	96	8	endoplasmic	endoplasmic	ADJ
finefocus-3321	96	9	reticulum	reticulum	NOUN
finefocus-3321	96	10	and	and	CCONJ
finefocus-3321	96	11	nuclear	nuclear	ADJ
finefocus-3321	96	12	envelope	envelope	NOUN
finefocus-3321	96	13	.	.	PUNCT
finefocus-3321	97	1	semin	semin	PROPN
finefocus-3321	97	2	cell	cell	PROPN
finefocus-3321	97	3	dev	dev	PROPN
finefocus-3321	97	4	biol	biol	PROPN
finefocus-3321	97	5	.	.	PUNCT
finefocus-3321	98	1	https://www.sciencedirect.com/	https://www.sciencedirect.com/	PROPN
finefocus-3321	98	2	science	science	PROPN
finefocus-3321	98	3	/	/	SYM
finefocus-3321	98	4	article	article	PROPN
finefocus-3321	98	5	/	/	SYM
finefocus-3321	98	6	pii	pii	PROPN
finefocus-3321	98	7	/	/	SYM
finefocus-3321	98	8	s1084952118300673	s1084952118300673	PROPN
finefocus-3321	98	9	volume	volume	NOUN
finefocus-3321	98	10	six	six	NUM
finefocus-3321	99	1	|	|	ADV
finefocus-3321	99	2	83	83	NUM
finefocus-3321	99	3	11	11	NUM
finefocus-3321	99	4	.	.	PUNCT
finefocus-3321	100	1	nillegoda	nillegoda	PROPN
finefocus-3321	100	2	,	,	PUNCT
finefocus-3321	100	3	n.	n.	PROPN
finefocus-3321	100	4	b.	b.	PROPN
finefocus-3321	100	5	,	,	PUNCT
finefocus-3321	100	6	theodoraki	theodoraki	PROPN
finefocus-3321	100	7	,	,	PUNCT
finefocus-3321	100	8	m.	m.	NOUN
finefocus-3321	100	9	a.	a.	PROPN
finefocus-3321	100	10	,	,	PUNCT
finefocus-3321	100	11	mandal	mandal	PROPN
finefocus-3321	100	12	,	,	PUNCT
finefocus-3321	100	13	a.	a.	PROPN
finefocus-3321	100	14	k.	k.	PROPN
finefocus-3321	100	15	,	,	PUNCT
finefocus-3321	100	16	mayo	mayo	PROPN
finefocus-3321	100	17	,	,	PUNCT
finefocus-3321	100	18	k.	k.	PROPN
finefocus-3321	100	19	j.	j.	PROPN
finefocus-3321	100	20	,	,	PUNCT
finefocus-3321	100	21	ren	ren	PROPN
finefocus-3321	100	22	,	,	PUNCT
finefocus-3321	100	23	h.	h.	PROPN
finefocus-3321	100	24	y.	y.	PROPN
finefocus-3321	100	25	,	,	PUNCT
finefocus-3321	100	26	sultana	sultana	PROPN
finefocus-3321	100	27	,	,	PUNCT
finefocus-3321	100	28	r.	r.	PROPN
finefocus-3321	100	29	,	,	PUNCT
finefocus-3321	100	30	.	.	PUNCT
finefocus-3321	100	31	.	.	PUNCT
finefocus-3321	100	32	.	.	PUNCT
finefocus-3321	101	1	caplan	caplan	PROPN
finefocus-3321	101	2	,	,	PUNCT
finefocus-3321	101	3	a.	a.	PROPN
finefocus-3321	101	4	j.	j.	PROPN
finefocus-3321	101	5	(	(	PUNCT
finefocus-3321	101	6	2010	2010	NUM
finefocus-3321	101	7	)	)	PUNCT
finefocus-3321	101	8	.	.	PUNCT
finefocus-3321	102	1	ubr1	ubr1	PROPN
finefocus-3321	102	2	and	and	CCONJ
finefocus-3321	102	3	ubr2	ubr2	NOUN
finefocus-3321	102	4	function	function	NOUN
finefocus-3321	102	5	in	in	ADP
finefocus-3321	102	6	a	a	DET
finefocus-3321	102	7	quality	quality	NOUN
finefocus-3321	102	8	control	control	NOUN
finefocus-3321	102	9	pathway	pathway	NOUN
finefocus-3321	102	10	for	for	ADP
finefocus-3321	102	11	degradation	degradation	NOUN
finefocus-3321	102	12	of	of	ADP
finefocus-3321	102	13	unfolded	unfold	VERB
finefocus-3321	102	14	cytosolic	cytosolic	ADJ
finefocus-3321	102	15	proteins	protein	NOUN
finefocus-3321	102	16	.	.	PUNCT
finefocus-3321	103	1	mol	mol	ADP
finefocus-3321	103	2	biol	biol	ADJ
finefocus-3321	103	3	cell	cell	NOUN
finefocus-3321	103	4	,	,	PUNCT
finefocus-3321	103	5	21(13	21(13	NUM
finefocus-3321	103	6	)	)	PUNCT
finefocus-3321	103	7	,	,	PUNCT
finefocus-3321	103	8	2102	2102	NUM
finefocus-3321	103	9	-	-	SYM
finefocus-3321	103	10	2116	2116	NUM
finefocus-3321	103	11	.	.	PUNCT
finefocus-3321	104	1	https://www.molbiolcell.org/doi/full/10.1091/	https://www.molbiolcell.org/doi/full/10.1091/	PROPN
finefocus-3321	104	2	mbc.e10	mbc.e10	PROPN
finefocus-3321	104	3	-	-	PUNCT
finefocus-3321	104	4	02	02	NUM
finefocus-3321	104	5	-	-	PUNCT
finefocus-3321	104	6	0098	0098	NUM
finefocus-3321	104	7	12	12	NUM
finefocus-3321	104	8	.	.	PUNCT
finefocus-3321	105	1	ruggiano	ruggiano	PROPN
finefocus-3321	105	2	,	,	PUNCT
finefocus-3321	105	3	a.	a.	PROPN
finefocus-3321	105	4	,	,	PUNCT
finefocus-3321	105	5	mora	mora	PROPN
finefocus-3321	105	6	,	,	PUNCT
finefocus-3321	105	7	g.	g.	PROPN
finefocus-3321	105	8	,	,	PUNCT
finefocus-3321	105	9	buxo	buxo	PROPN
finefocus-3321	105	10	,	,	PUNCT
finefocus-3321	105	11	l.	l.	PROPN
finefocus-3321	105	12	,	,	PUNCT
finefocus-3321	105	13	&	&	CCONJ
finefocus-3321	105	14	carvalho	carvalho	PROPN
finefocus-3321	105	15	,	,	PUNCT
finefocus-3321	105	16	p.	p.	NOUN
finefocus-3321	105	17	(	(	PUNCT
finefocus-3321	105	18	2016	2016	NUM
finefocus-3321	105	19	)	)	PUNCT
finefocus-3321	105	20	.	.	PUNCT
finefocus-3321	106	1	spatial	spatial	ADJ
finefocus-3321	106	2	control	control	NOUN
finefocus-3321	106	3	of	of	ADP
finefocus-3321	106	4	lipid	lipid	ADJ
finefocus-3321	106	5	droplet	droplet	ADJ
finefocus-3321	106	6	proteins	protein	NOUN
finefocus-3321	106	7	by	by	ADP
finefocus-3321	106	8	the	the	DET
finefocus-3321	106	9	erad	erad	ADJ
finefocus-3321	106	10	ubiquitin	ubiquitin	PROPN
finefocus-3321	106	11	ligase	ligase	PROPN
finefocus-3321	106	12	doa10	doa10	PROPN
finefocus-3321	106	13	.	.	PUNCT
finefocus-3321	107	1	embo	embo	PROPN
finefocus-3321	107	2	j	j	PROPN
finefocus-3321	107	3	,	,	PUNCT
finefocus-3321	107	4	35(15	35(15	NUM
finefocus-3321	107	5	)	)	PUNCT
finefocus-3321	107	6	,	,	PUNCT
finefocus-3321	107	7	1644	1644	NUM
finefocus-3321	107	8	-	-	SYM
finefocus-3321	107	9	1655	1655	NUM
finefocus-3321	107	10	.	.	PUNCT
finefocus-3321	108	1	https://www.embopress.org/doi/	https://www.embopress.org/doi/	PROPN
finefocus-3321	108	2	full/10.15252	full/10.15252	PROPN
finefocus-3321	108	3	/	/	SYM
finefocus-3321	108	4	embj.201593106	embj.201593106	PROPN
finefocus-3321	108	5	13	13	NUM
finefocus-3321	108	6	.	.	PUNCT
finefocus-3321	109	1	stolz	stolz	PROPN
finefocus-3321	109	2	,	,	PUNCT
finefocus-3321	109	3	a.	a.	NOUN
finefocus-3321	109	4	,	,	PUNCT
finefocus-3321	109	5	besser	besser	NOUN
finefocus-3321	109	6	,	,	PUNCT
finefocus-3321	109	7	s.	s.	PROPN
finefocus-3321	109	8	,	,	PUNCT
finefocus-3321	109	9	hottmann	hottmann	PROPN
finefocus-3321	109	10	,	,	PUNCT
finefocus-3321	109	11	h.	h.	PROPN
finefocus-3321	109	12	,	,	PUNCT
finefocus-3321	109	13	&	&	CCONJ
finefocus-3321	109	14	wolf	wolf	PROPN
finefocus-3321	109	15	,	,	PUNCT
finefocus-3321	109	16	d.	d.	PROPN
finefocus-3321	109	17	h.	h.	PROPN
finefocus-3321	109	18	(	(	PUNCT
finefocus-3321	109	19	2013	2013	NUM
finefocus-3321	109	20	)	)	PUNCT
finefocus-3321	109	21	.	.	PUNCT
finefocus-3321	110	1	previously	previously	ADV
finefocus-3321	110	2	unknown	unknown	ADJ
finefocus-3321	110	3	role	role	NOUN
finefocus-3321	110	4	for	for	ADP
finefocus-3321	110	5	the	the	DET
finefocus-3321	110	6	ubiquitin	ubiquitin	NOUN
finefocus-3321	110	7	ligase	ligase	PROPN
finefocus-3321	110	8	ubr1	ubr1	PROPN
finefocus-3321	110	9	in	in	ADP
finefocus-3321	110	10	endoplasmic	endoplasmic	ADJ
finefocus-3321	110	11	reticulum	reticulum	NOUN
finefocus-3321	110	12	-	-	PUNCT
finefocus-3321	110	13	associated	associate	VERB
finefocus-3321	110	14	protein	protein	NOUN
finefocus-3321	110	15	degradation	degradation	NOUN
finefocus-3321	110	16	.	.	PUNCT
finefocus-3321	111	1	proc	proc	PROPN
finefocus-3321	111	2	natl	natl	PROPN
finefocus-3321	111	3	acad	acad	PROPN
finefocus-3321	111	4	sci	sci	PROPN
finefocus-3321	111	5	u	u	PROPN
finefocus-3321	111	6	s	s	PROPN
finefocus-3321	111	7	a	a	DET
finefocus-3321	111	8	,	,	PUNCT
finefocus-3321	111	9	110(38	110(38	NUM
finefocus-3321	111	10	)	)	PUNCT
finefocus-3321	111	11	,	,	PUNCT
finefocus-3321	111	12	15271	15271	NUM
finefocus-3321	111	13	-	-	SYM
finefocus-3321	111	14	15276	15276	NUM
finefocus-3321	111	15	.	.	PUNCT
finefocus-3321	112	1	https://www.pnas.org/content/110/38/15271.long	https://www.pnas.org/content/110/38/15271.long	PROPN
finefocus-3321	112	2	14	14	NUM
finefocus-3321	112	3	.	.	PUNCT
finefocus-3321	113	1	szoradi	szoradi	NOUN
finefocus-3321	113	2	,	,	PUNCT
finefocus-3321	113	3	t.	t.	PROPN
finefocus-3321	113	4	,	,	PUNCT
finefocus-3321	113	5	schaeff	schaeff	PROPN
finefocus-3321	113	6	,	,	PUNCT
finefocus-3321	113	7	k.	k.	PROPN
finefocus-3321	113	8	,	,	PUNCT
finefocus-3321	113	9	garcia	garcia	PROPN
finefocus-3321	113	10	-	-	PUNCT
finefocus-3321	113	11	rivera	rivera	PROPN
finefocus-3321	113	12	,	,	PUNCT
finefocus-3321	113	13	e.	e.	PROPN
finefocus-3321	113	14	m.	m.	PROPN
finefocus-3321	113	15	,	,	PUNCT
finefocus-3321	113	16	itzhak	itzhak	PROPN
finefocus-3321	113	17	,	,	PUNCT
finefocus-3321	113	18	d.	d.	PROPN
finefocus-3321	113	19	n.	n.	PROPN
finefocus-3321	113	20	,	,	PUNCT
finefocus-3321	113	21	schmidt	schmidt	PROPN
finefocus-3321	113	22	,	,	PUNCT
finefocus-3321	113	23	r.	r.	PROPN
finefocus-3321	113	24	m.	m.	PROPN
finefocus-3321	113	25	,	,	PUNCT
finefocus-3321	113	26	bircham	bircham	PROPN
finefocus-3321	113	27	,	,	PUNCT
finefocus-3321	113	28	p.	p.	PROPN
finefocus-3321	113	29	w.	w.	PROPN
finefocus-3321	113	30	,	,	PUNCT
finefocus-3321	113	31	.	.	PUNCT
finefocus-3321	113	32	.	.	PUNCT
finefocus-3321	114	1	.	.	PUNCT
finefocus-3321	115	1	schuck	schuck	PROPN
finefocus-3321	115	2	,	,	PUNCT
finefocus-3321	115	3	s.	s.	PROPN
finefocus-3321	115	4	(	(	PUNCT
finefocus-3321	115	5	2018	2018	NUM
finefocus-3321	115	6	)	)	PUNCT
finefocus-3321	115	7	.	.	PUNCT
finefocus-3321	116	1	shred	shred	PROPN
finefocus-3321	116	2	is	be	AUX
finefocus-3321	116	3	a	a	DET
finefocus-3321	116	4	regulatory	regulatory	ADJ
finefocus-3321	116	5	cascade	cascade	NOUN
finefocus-3321	116	6	that	that	PRON
finefocus-3321	116	7	reprograms	reprogram	VERB
finefocus-3321	116	8	ubr1	ubr1	PROPN
finefocus-3321	116	9	substrate	substrate	NOUN
finefocus-3321	116	10	specificity	specificity	NOUN
finefocus-3321	116	11	for	for	ADP
finefocus-3321	116	12	enhanced	enhanced	ADJ
finefocus-3321	116	13	protein	protein	NOUN
finefocus-3321	116	14	quality	quality	NOUN
finefocus-3321	116	15	control	control	NOUN
finefocus-3321	116	16	during	during	ADP
finefocus-3321	116	17	stress	stress	NOUN
finefocus-3321	116	18	.	.	PUNCT
finefocus-3321	117	1	mol	mol	ADP
finefocus-3321	117	2	cell	cell	NOUN
finefocus-3321	117	3	,	,	PUNCT
finefocus-3321	117	4	70(6	70(6	NOUN
finefocus-3321	117	5	)	)	PUNCT
finefocus-3321	117	6	,	,	PUNCT
finefocus-3321	117	7	1025	1025	NUM
finefocus-3321	117	8	-	-	SYM
finefocus-3321	117	9	1037	1037	NUM
finefocus-3321	117	10	e1025	e1025	PROPN
finefocus-3321	117	11	.	.	PUNCT
finefocus-3321	118	1	https://www.cell	https://www.cell	PROPN
finefocus-3321	118	2	.	.	PUNCT
finefocus-3321	118	3	com	com	NOUN
finefocus-3321	118	4	/	/	SYM
finefocus-3321	118	5	molecular	molecular	ADJ
finefocus-3321	118	6	-	-	PUNCT
finefocus-3321	118	7	cell	cell	NOUN
finefocus-3321	118	8	/	/	SYM
finefocus-3321	118	9	fulltext	fulltext	NOUN
finefocus-3321	118	10	/	/	SYM
finefocus-3321	118	11	s1097	s1097	PROPN
finefocus-3321	118	12	-	-	PUNCT
finefocus-3321	118	13	2765(18)30349	2765(18)30349	NUM
finefocus-3321	118	14	-	-	SYM
finefocus-3321	118	15	6	6	NUM
finefocus-3321	118	16	15	15	NUM
finefocus-3321	118	17	.	.	PUNCT
finefocus-3321	119	1	theodoraki	theodoraki	PROPN
finefocus-3321	119	2	,	,	PUNCT
finefocus-3321	119	3	m.	m.	NOUN
finefocus-3321	119	4	a.	a.	PROPN
finefocus-3321	119	5	,	,	PUNCT
finefocus-3321	119	6	nillegoda	nillegoda	PROPN
finefocus-3321	119	7	,	,	PUNCT
finefocus-3321	119	8	n.	n.	PROPN
finefocus-3321	119	9	b.	b.	PROPN
finefocus-3321	119	10	,	,	PUNCT
finefocus-3321	119	11	saini	saini	PROPN
finefocus-3321	119	12	,	,	PUNCT
finefocus-3321	119	13	j.	j.	PROPN
finefocus-3321	119	14	,	,	PUNCT
finefocus-3321	119	15	&	&	CCONJ
finefocus-3321	119	16	caplan	caplan	PROPN
finefocus-3321	119	17	,	,	PUNCT
finefocus-3321	119	18	a.	a.	PROPN
finefocus-3321	119	19	j.	j.	PROPN
finefocus-3321	119	20	(	(	PUNCT
finefocus-3321	119	21	2012	2012	NUM
finefocus-3321	119	22	)	)	PUNCT
finefocus-3321	119	23	.	.	PUNCT
finefocus-3321	120	1	a	a	DET
finefocus-3321	120	2	network	network	NOUN
finefocus-3321	120	3	of	of	ADP
finefocus-3321	120	4	ubiquitin	ubiquitin	ADJ
finefocus-3321	120	5	ligases	ligase	NOUN
finefocus-3321	120	6	is	be	AUX
finefocus-3321	120	7	important	important	ADJ
finefocus-3321	120	8	for	for	ADP
finefocus-3321	120	9	the	the	DET
finefocus-3321	120	10	dynamics	dynamic	NOUN
finefocus-3321	120	11	of	of	ADP
finefocus-3321	120	12	misfolded	misfolde	VERB
finefocus-3321	120	13	protein	protein	NOUN
finefocus-3321	120	14	aggregates	aggregate	NOUN
finefocus-3321	120	15	in	in	ADP
finefocus-3321	120	16	yeast	yeast	NOUN
finefocus-3321	120	17	.	.	PUNCT
finefocus-3321	121	1	j	j	PROPN
finefocus-3321	121	2	biol	biol	PROPN
finefocus-3321	121	3	chem	chem	NOUN
finefocus-3321	121	4	,	,	PUNCT
finefocus-3321	121	5	287(28	287(28	NUM
finefocus-3321	121	6	)	)	PUNCT
finefocus-3321	121	7	,	,	PUNCT
finefocus-3321	121	8	2391123922	2391123922	NUM
finefocus-3321	121	9	.	.	PUNCT
finefocus-3321	122	1	http://www.jbc.org/content/287/28/23911.full	http://www.jbc.org/content/287/28/23911.full	NOUN
finefocus-3321	122	2	16	16	NUM
finefocus-3321	122	3	.	.	PUNCT
finefocus-3321	123	1	tong	tong	PROPN
finefocus-3321	123	2	,	,	PUNCT
finefocus-3321	123	3	a.	a.	PROPN
finefocus-3321	123	4	h.	h.	PROPN
finefocus-3321	123	5	,	,	PUNCT
finefocus-3321	123	6	evangelista	evangelista	PROPN
finefocus-3321	123	7	,	,	PUNCT
finefocus-3321	123	8	m.	m.	NOUN
finefocus-3321	123	9	,	,	PUNCT
finefocus-3321	123	10	parsons	parson	NOUN
finefocus-3321	123	11	,	,	PUNCT
finefocus-3321	123	12	a.	a.	PROPN
finefocus-3321	123	13	b.	b.	PROPN
finefocus-3321	123	14	,	,	PUNCT
finefocus-3321	123	15	xu	xu	PROPN
finefocus-3321	123	16	,	,	PUNCT
finefocus-3321	123	17	h.	h.	PROPN
finefocus-3321	123	18	,	,	PUNCT
finefocus-3321	123	19	bader	bader	PROPN
finefocus-3321	123	20	,	,	PUNCT
finefocus-3321	123	21	g.	g.	PROPN
finefocus-3321	123	22	d.	d.	PROPN
finefocus-3321	123	23	,	,	PUNCT
finefocus-3321	123	24	page	page	NOUN
finefocus-3321	123	25	,	,	PUNCT
finefocus-3321	123	26	n.	n.	NOUN
finefocus-3321	123	27	,	,	PUNCT
finefocus-3321	123	28	.	.	PUNCT
finefocus-3321	123	29	.	.	PUNCT
finefocus-3321	123	30	.	.	PUNCT
finefocus-3321	124	1	boone	boone	PROPN
finefocus-3321	124	2	,	,	PUNCT
finefocus-3321	124	3	c.	c.	PROPN
finefocus-3321	124	4	(	(	PUNCT
finefocus-3321	124	5	2001	2001	NUM
finefocus-3321	124	6	)	)	PUNCT
finefocus-3321	124	7	.	.	PUNCT
finefocus-3321	125	1	systematic	systematic	ADJ
finefocus-3321	125	2	genetic	genetic	ADJ
finefocus-3321	125	3	analysis	analysis	NOUN
finefocus-3321	125	4	with	with	ADP
finefocus-3321	125	5	ordered	order	VERB
finefocus-3321	125	6	arrays	array	NOUN
finefocus-3321	125	7	of	of	ADP
finefocus-3321	125	8	yeast	yeast	NOUN
finefocus-3321	125	9	deletion	deletion	NOUN
finefocus-3321	125	10	mutants	mutant	NOUN
finefocus-3321	125	11	.	.	PUNCT
finefocus-3321	126	1	science	science	PROPN
finefocus-3321	126	2	,	,	PUNCT
finefocus-3321	126	3	294(5550	294(5550	NUM
finefocus-3321	126	4	)	)	PUNCT
finefocus-3321	126	5	,	,	PUNCT
finefocus-3321	126	6	23642368	23642368	NUM
finefocus-3321	126	7	.	.	PUNCT
finefocus-3321	127	1	https://science.sciencemag.org/content/294/5550/2364.full	https://science.sciencemag.org/content/294/5550/2364.full	PROPN
finefocus-3321	127	2	17	17	NUM
finefocus-3321	127	3	.	.	PUNCT
finefocus-3321	127	4	varshavsky	varshavsky	PROPN
finefocus-3321	127	5	,	,	PUNCT
finefocus-3321	127	6	a.	a.	NOUN
finefocus-3321	127	7	(	(	PUNCT
finefocus-3321	127	8	2011	2011	NUM
finefocus-3321	127	9	)	)	PUNCT
finefocus-3321	127	10	.	.	PUNCT
finefocus-3321	128	1	the	the	DET
finefocus-3321	128	2	n	n	NUM
finefocus-3321	128	3	-	-	PUNCT
finefocus-3321	128	4	end	end	NOUN
finefocus-3321	128	5	rule	rule	NOUN
finefocus-3321	128	6	pathway	pathway	NOUN
finefocus-3321	128	7	and	and	CCONJ
finefocus-3321	128	8	regulation	regulation	NOUN
finefocus-3321	128	9	by	by	ADP
finefocus-3321	128	10	proteolysis	proteolysis	NOUN
finefocus-3321	128	11	.	.	PUNCT
finefocus-3321	129	1	protein	protein	NOUN
finefocus-3321	129	2	sci	sci	PROPN
finefocus-3321	129	3	,	,	PUNCT
finefocus-3321	129	4	20(8	20(8	NOUN
finefocus-3321	129	5	)	)	PUNCT
finefocus-3321	129	6	,	,	PUNCT
finefocus-3321	129	7	12981345	12981345	NUM
finefocus-3321	129	8	.	.	PUNCT
finefocus-3321	130	1	https://onlinelibrary.wiley.com/doi/full/10.1002/pro.666	https://onlinelibrary.wiley.com/doi/full/10.1002/pro.666	PROPN
finefocus-3321	130	2	18	18	NUM
finefocus-3321	130	3	.	.	PUNCT
finefocus-3321	131	1	watts	watts	PROPN
finefocus-3321	131	2	,	,	PUNCT
finefocus-3321	131	3	s.	s.	PROPN
finefocus-3321	131	4	g.	g.	PROPN
finefocus-3321	131	5	,	,	PUNCT
finefocus-3321	131	6	crowder	crowder	PROPN
finefocus-3321	131	7	,	,	PUNCT
finefocus-3321	131	8	j.	j.	PROPN
finefocus-3321	131	9	j.	j.	PROPN
finefocus-3321	131	10	,	,	PUNCT
finefocus-3321	131	11	coffey	coffey	PROPN
finefocus-3321	131	12	,	,	PUNCT
finefocus-3321	131	13	s.	s.	PROPN
finefocus-3321	131	14	z.	z.	PROPN
finefocus-3321	131	15	,	,	PUNCT
finefocus-3321	131	16	&	&	CCONJ
finefocus-3321	131	17	rubenstein	rubenstein	PROPN
finefocus-3321	131	18	,	,	PUNCT
finefocus-3321	131	19	e.	e.	PROPN
finefocus-3321	131	20	m.	m.	PROPN
finefocus-3321	131	21	(	(	PUNCT
finefocus-3321	131	22	2015	2015	NUM
finefocus-3321	131	23	)	)	PUNCT
finefocus-3321	131	24	.	.	PUNCT
finefocus-3321	132	1	growth	growth	NOUN
finefocus-3321	132	2	-	-	PUNCT
finefocus-3321	132	3	based	base	VERB
finefocus-3321	132	4	determination	determination	NOUN
finefocus-3321	132	5	and	and	CCONJ
finefocus-3321	132	6	biochemical	biochemical	ADJ
finefocus-3321	132	7	confirmation	confirmation	NOUN
finefocus-3321	132	8	of	of	ADP
finefocus-3321	132	9	genetic	genetic	ADJ
finefocus-3321	132	10	requirements	requirement	NOUN
finefocus-3321	132	11	for	for	ADP
finefocus-3321	132	12	protein	protein	NOUN
finefocus-3321	132	13	degradation	degradation	NOUN
finefocus-3321	132	14	in	in	ADP
finefocus-3321	132	15	saccharomyces	saccharomyce	NOUN
finefocus-3321	132	16	cerevisiae	cerevisiae	NOUN
finefocus-3321	132	17	.	.	PUNCT
finefocus-3321	133	1	journal	journal	NOUN
finefocus-3321	133	2	of	of	ADP
finefocus-3321	133	3	visualized	visualized	ADJ
finefocus-3321	133	4	experiments	experiment	NOUN
finefocus-3321	133	5	,	,	PUNCT
finefocus-3321	133	6	(	(	PUNCT
finefocus-3321	133	7	96	96	NUM
finefocus-3321	133	8	)	)	PUNCT
finefocus-3321	133	9	,	,	PUNCT
finefocus-3321	133	10	e52428	e52428	NUM
finefocus-3321	133	11	.	.	PUNCT
finefocus-3321	134	1	https://www.jove.com/video/52428/	https://www.jove.com/video/52428/	ADJ
finefocus-3321	134	2	growth	growth	NOUN
finefocus-3321	134	3	-	-	PUNCT
finefocus-3321	134	4	based	base	VERB
finefocus-3321	134	5	-	-	PUNCT
finefocus-3321	134	6	determination	determination	NOUN
finefocus-3321	134	7	-	-	PUNCT
finefocus-3321	134	8	biochemical	biochemical	ADJ
finefocus-3321	134	9	-	-	PUNCT
finefocus-3321	134	10	confirmation	confirmation	NOUN
finefocus-3321	134	11	-	-	PUNCT
finefocus-3321	134	12	genetic	genetic	ADJ
finefocus-3321	134	13	19	19	NUM
finefocus-3321	134	14	.	.	PUNCT
finefocus-3321	135	1	zenker	zenker	PROPN
finefocus-3321	135	2	,	,	PUNCT
finefocus-3321	135	3	m.	m.	NOUN
finefocus-3321	135	4	,	,	PUNCT
finefocus-3321	135	5	mayerle	mayerle	NOUN
finefocus-3321	135	6	,	,	PUNCT
finefocus-3321	135	7	j.	j.	PROPN
finefocus-3321	135	8	,	,	PUNCT
finefocus-3321	135	9	lerch	lerch	PROPN
finefocus-3321	135	10	,	,	PUNCT
finefocus-3321	135	11	m.	m.	NOUN
finefocus-3321	135	12	m.	m.	NOUN
finefocus-3321	135	13	,	,	PUNCT
finefocus-3321	135	14	tagariello	tagariello	PROPN
finefocus-3321	135	15	,	,	PUNCT
finefocus-3321	135	16	a.	a.	NOUN
finefocus-3321	135	17	,	,	PUNCT
finefocus-3321	135	18	zerres	zerres	PROPN
finefocus-3321	135	19	,	,	PUNCT
finefocus-3321	135	20	k.	k.	PROPN
finefocus-3321	135	21	,	,	PUNCT
finefocus-3321	135	22	durie	durie	PROPN
finefocus-3321	135	23	,	,	PUNCT
finefocus-3321	135	24	p.	p.	PROPN
finefocus-3321	135	25	r.	r.	PROPN
finefocus-3321	135	26	,	,	PUNCT
finefocus-3321	135	27	.	.	PUNCT
finefocus-3321	135	28	.	.	PUNCT
finefocus-3321	135	29	.	.	PUNCT
finefocus-3321	136	1	reis	reis	NOUN
finefocus-3321	136	2	,	,	PUNCT
finefocus-3321	136	3	a.	a.	NOUN
finefocus-3321	136	4	(	(	PUNCT
finefocus-3321	136	5	2005	2005	NUM
finefocus-3321	136	6	)	)	PUNCT
finefocus-3321	136	7	.	.	PUNCT
finefocus-3321	137	1	deficiency	deficiency	NOUN
finefocus-3321	137	2	of	of	ADP
finefocus-3321	137	3	ubr1	ubr1	PROPN
finefocus-3321	137	4	,	,	PUNCT
finefocus-3321	137	5	a	a	DET
finefocus-3321	137	6	ubiquitin	ubiquitin	ADJ
finefocus-3321	137	7	ligase	ligase	NOUN
finefocus-3321	137	8	of	of	ADP
finefocus-3321	137	9	the	the	DET
finefocus-3321	137	10	n	n	NUM
finefocus-3321	137	11	-	-	PUNCT
finefocus-3321	137	12	end	end	NOUN
finefocus-3321	137	13	rule	rule	NOUN
finefocus-3321	137	14	pathway	pathway	NOUN
finefocus-3321	137	15	,	,	PUNCT
finefocus-3321	137	16	causes	cause	VERB
finefocus-3321	137	17	pancreatic	pancreatic	ADJ
finefocus-3321	137	18	dysfunction	dysfunction	NOUN
finefocus-3321	137	19	,	,	PUNCT
finefocus-3321	137	20	malformations	malformation	NOUN
finefocus-3321	137	21	and	and	CCONJ
finefocus-3321	137	22	mental	mental	ADJ
finefocus-3321	137	23	retardation	retardation	NOUN
finefocus-3321	137	24	(	(	PUNCT
finefocus-3321	137	25	johanson	johanson	PROPN
finefocus-3321	137	26	-	-	PUNCT
finefocus-3321	137	27	blizzard	blizzard	PROPN
finefocus-3321	137	28	syndrome	syndrome	NOUN
finefocus-3321	137	29	)	)	PUNCT
finefocus-3321	137	30	.	.	PUNCT
finefocus-3321	138	1	nat	nat	PROPN
finefocus-3321	138	2	genet	genet	PROPN
finefocus-3321	138	3	,	,	PUNCT
finefocus-3321	138	4	37(12	37(12	NUM
finefocus-3321	138	5	)	)	PUNCT
finefocus-3321	138	6	,	,	PUNCT
finefocus-3321	138	7	1345	1345	NUM
finefocus-3321	138	8	-	-	SYM
finefocus-3321	138	9	1350	1350	NUM
finefocus-3321	138	10	.	.	PUNCT
finefocus-3321	139	1	https://www.nature.com/	https://www.nature.com/	PROPN
finefocus-3321	139	2	articles	articles	PROPN
finefocus-3321	139	3	/	/	SYM
finefocus-3321	139	4	ng1681	ng1681	PROPN