id	sid	tid	token	lemma	pos
finefocus-5274	1	1	2025	2025	NUM
finefocus-5274	1	2	swain	swain	PROPN
finefocus-5274	1	3	,	,	PUNCT
finefocus-5274	1	4	colburn	colburn	PROPN
finefocus-5274	1	5	,	,	PUNCT
finefocus-5274	1	6	de	de	PROPN
finefocus-5274	1	7	andrade	andrade	PROPN
finefocus-5274	1	8	,	,	PUNCT
finefocus-5274	1	9	rosales	rosale	NOUN
finefocus-5274	1	10	,	,	PUNCT
finefocus-5274	1	11	addorisio	addorisio	PROPN
finefocus-5274	1	12	,	,	PUNCT
finefocus-5274	1	13	stuart	stuart	PROPN
finefocus-5274	1	14	,	,	PUNCT
finefocus-5274	1	15	galvao	galvao	PROPN
finefocus-5274	1	16	,	,	PUNCT
finefocus-5274	1	17	hubisz	hubisz	ADJ
finefocus-5274	1	18	,	,	PUNCT
finefocus-5274	1	19	ouellette	ouellette	NOUN
finefocus-5274	1	20	,	,	PUNCT
finefocus-5274	1	21	hamssa	hamssa	NOUN
finefocus-5274	1	22	,	,	PUNCT
finefocus-5274	1	23	laranjo	laranjo	NOUN
finefocus-5274	1	24	,	,	PUNCT
finefocus-5274	1	25	pina	pina	NOUN
finefocus-5274	1	26	.	.	PUNCT
finefocus-5274	2	1	fine	fine	ADJ
finefocus-5274	2	2	focus	focus	NOUN
finefocus-5274	2	3	,	,	PUNCT
finefocus-5274	2	4	11(1	11(1	NUM
finefocus-5274	2	5	)	)	PUNCT
finefocus-5274	2	6	,	,	PUNCT
finefocus-5274	2	7	12	12	NUM
finefocus-5274	2	8	-	-	SYM
finefocus-5274	2	9	23	23	NUM
finefocus-5274	2	10	.	.	PUNCT
finefocus-5274	3	1	doi	doi	NOUN
finefocus-5274	3	2	:	:	PUNCT
finefocus-5274	3	3	10.33043	10.33043	NUM
finefocus-5274	3	4	/	/	SYM
finefocus-5274	3	5	rq7a84ax	rq7a84ax	NOUN
finefocus-5274	3	6	shared	share	VERB
finefocus-5274	3	7	with	with	ADP
finefocus-5274	3	8	cc	cc	NOUN
finefocus-5274	3	9	-	-	PUNCT
finefocus-5274	3	10	by	by	ADP
finefocus-5274	3	11	-	-	PUNCT
finefocus-5274	3	12	nc	nc	VERB
finefocus-5274	3	13	-	-	PROPN
finefocus-5274	3	14	nd	nd	ADV
finefocus-5274	3	15	4.0	4.0	NUM
finefocus-5274	3	16	license	license	NOUN
finefocus-5274	3	17	.	.	PUNCT
finefocus-5274	4	1	analyzing	analyze	VERB
finefocus-5274	4	2	selected	select	VERB
finefocus-5274	4	3	fda	fda	PROPN
finefocus-5274	4	4	approved	approve	VERB
finefocus-5274	4	5	drugs	drug	NOUN
finefocus-5274	4	6	for	for	ADP
finefocus-5274	4	7	effects	effect	NOUN
finefocus-5274	4	8	on	on	ADP
finefocus-5274	4	9	template	template	NOUN
finefocus-5274	4	10	switch	switch	NOUN
finefocus-5274	4	11	mutagenesis	mutagenesis	NOUN
finefocus-5274	4	12	in	in	ADP
finefocus-5274	4	13	e.	e.	PROPN
finefocus-5274	4	14	coli	coli	PROPN
finefocus-5274	4	15	april	april	PROPN
finefocus-5274	4	16	swain1	swain1	PROPN
finefocus-5274	4	17	emily	emily	PROPN
finefocus-5274	4	18	colburn1	colburn1	PROPN
finefocus-5274	4	19	0009	0009	NUM
finefocus-5274	4	20	-	-	PUNCT
finefocus-5274	4	21	0001	0001	NUM
finefocus-5274	4	22	-	-	PUNCT
finefocus-5274	4	23	6905	6905	NUM
finefocus-5274	4	24	-	-	PUNCT
finefocus-5274	4	25	2381	2381	NUM
finefocus-5274	4	26	kamila	kamila	PROPN
finefocus-5274	4	27	de	de	PROPN
finefocus-5274	4	28	andrade2	andrade2	PROPN
finefocus-5274	4	29	pamela	pamela	PROPN
finefocus-5274	4	30	rosales2	rosales2	PROPN
finefocus-5274	4	31	sydney	sydney	PROPN
finefocus-5274	4	32	addorisio2	addorisio2	PROPN
finefocus-5274	5	1	0009	0009	NUM
finefocus-5274	5	2	-	-	PUNCT
finefocus-5274	5	3	0001	0001	NUM
finefocus-5274	5	4	-	-	PUNCT
finefocus-5274	5	5	3776	3776	NUM
finefocus-5274	5	6	-	-	PUNCT
finefocus-5274	5	7	5870	5870	NUM
finefocus-5274	5	8	taylor	taylor	PROPN
finefocus-5274	5	9	stuart2	stuart2	PROPN
finefocus-5274	5	10	angelina	angelina	PROPN
finefocus-5274	5	11	galvao1	galvao1	PROPN
finefocus-5274	5	12	leigha	leigha	PROPN
finefocus-5274	5	13	hubisz2	hubisz2	PROPN
finefocus-5274	5	14	margaret	margaret	PROPN
finefocus-5274	6	1	ouellette1	ouellette1	PROPN
finefocus-5274	6	2	rana	rana	PROPN
finefocus-5274	6	3	hamssa1	hamssa1	PROPN
finefocus-5274	6	4	laura	laura	PROPN
finefocus-5274	6	5	laranjo2	laranjo2	PROPN
finefocus-5274	6	6	0000	0000	NUM
finefocus-5274	6	7	-	-	PUNCT
finefocus-5274	6	8	0002	0002	NUM
finefocus-5274	6	9	-	-	PUNCT
finefocus-5274	6	10	1225	1225	NUM
finefocus-5274	6	11	-	-	PUNCT
finefocus-5274	6	12	8821	8821	NUM
finefocus-5274	6	13	cara	cara	X
finefocus-5274	6	14	pina1	pina1	PROPN
finefocus-5274	6	15	0000	0000	NUM
finefocus-5274	6	16	-	-	PUNCT
finefocus-5274	6	17	0002	0002	NUM
finefocus-5274	6	18	-	-	PUNCT
finefocus-5274	6	19	8098	8098	NUM
finefocus-5274	6	20	-	-	SYM
finefocus-5274	6	21	8148	8148	NUM
finefocus-5274	6	22	1framingham	1framingham	NUM
finefocus-5274	6	23	state	state	NOUN
finefocus-5274	6	24	university	university	PROPN
finefocus-5274	6	25	framingham	framingham	PROPN
finefocus-5274	6	26	,	,	PUNCT
finefocus-5274	6	27	ma	ma	PROPN
finefocus-5274	6	28	usa	usa	PROPN
finefocus-5274	6	29	2	2	PROPN
finefocus-5274	6	30	salem	salem	PROPN
finefocus-5274	6	31	state	state	NOUN
finefocus-5274	6	32	university	university	PROPN
finefocus-5274	6	33	salem	salem	NOUN
finefocus-5274	6	34	,	,	PUNCT
finefocus-5274	6	35	ma	ma	PROPN
finefocus-5274	6	36	,	,	PUNCT
finefocus-5274	6	37	usa	usa	PROPN
finefocus-5274	6	38	https://creativecommons.org/licenses/by-nc-nd/4.0/	https://creativecommons.org/licenses/by-nc-nd/4.0/	PROPN
finefocus-5274	6	39	https://orcid.org/0009-0001-6905-2381	https://orcid.org/0009-0001-6905-2381	PROPN
finefocus-5274	6	40	https://orcid.org/0009-0001-3776-5870	https://orcid.org/0009-0001-3776-5870	PROPN
finefocus-5274	6	41	https://orcid.org/0000-0002-1225-8821	https://orcid.org/0000-0002-1225-8821	VERB
finefocus-5274	6	42	https://orcid.org/0000-0002-8098-8148	https://orcid.org/0000-0002-8098-8148	PROPN
finefocus-5274	6	43	swain	swain	PROPN
finefocus-5274	6	44	et	et	PROPN
finefocus-5274	6	45	al	al	PROPN
finefocus-5274	6	46	.	.	PUNCT
finefocus-5274	7	1	|	|	ADV
finefocus-5274	7	2	analyzing	analyze	VERB
finefocus-5274	7	3	selected	select	VERB
finefocus-5274	7	4	fda	fda	PROPN
finefocus-5274	7	5	approved	approve	VERB
finefocus-5274	7	6	drugs	drug	NOUN
finefocus-5274	7	7	for	for	ADP
finefocus-5274	7	8	effects	effect	NOUN
finefocus-5274	7	9	on	on	ADP
finefocus-5274	7	10	template	template	NOUN
finefocus-5274	7	11	switch	switch	NOUN
finefocus-5274	7	12	mutagenesis	mutagenesis	NOUN
finefocus-5274	7	13	in	in	ADP
finefocus-5274	7	14	e.	e.	PROPN
finefocus-5274	7	15	coli	coli	PROPN
finefocus-5274	7	16	13	13	NUM
finefocus-5274	7	17	introduction	introduction	NOUN
finefocus-5274	7	18	dna	dna	PROPN
finefocus-5274	7	19	mutations	mutation	NOUN
finefocus-5274	7	20	,	,	PUNCT
finefocus-5274	7	21	changes	change	NOUN
finefocus-5274	7	22	that	that	PRON
finefocus-5274	7	23	occur	occur	VERB
finefocus-5274	7	24	during	during	ADP
finefocus-5274	7	25	dna	dna	PROPN
finefocus-5274	7	26	replication	replication	NOUN
finefocus-5274	7	27	,	,	PUNCT
finefocus-5274	7	28	can	can	AUX
finefocus-5274	7	29	induce	induce	VERB
finefocus-5274	7	30	genetic	genetic	ADJ
finefocus-5274	7	31	instability	instability	NOUN
finefocus-5274	7	32	.	.	PUNCT
finefocus-5274	8	1	among	among	ADP
finefocus-5274	8	2	various	various	ADJ
finefocus-5274	8	3	mutation	mutation	NOUN
finefocus-5274	8	4	classes	class	NOUN
finefocus-5274	8	5	,	,	PUNCT
finefocus-5274	8	6	this	this	DET
finefocus-5274	8	7	study	study	NOUN
finefocus-5274	8	8	investigates	investigate	VERB
finefocus-5274	8	9	mutations	mutation	NOUN
finefocus-5274	8	10	caused	cause	VERB
finefocus-5274	8	11	by	by	ADP
finefocus-5274	8	12	dna	dna	PROPN
finefocus-5274	8	13	secondary	secondary	ADJ
finefocus-5274	8	14	structures	structure	NOUN
finefocus-5274	8	15	able	able	ADJ
finefocus-5274	8	16	to	to	PART
finefocus-5274	8	17	form	form	VERB
finefocus-5274	8	18	quasi	quasi	NOUN
finefocus-5274	8	19	palindromes	palindrome	NOUN
finefocus-5274	8	20	(	(	PUNCT
finefocus-5274	8	21	qps	qps	PROPN
finefocus-5274	8	22	)	)	PUNCT
finefocus-5274	8	23	.	.	PUNCT
finefocus-5274	9	1	qps	qps	PROPN
finefocus-5274	9	2	are	be	AUX
finefocus-5274	9	3	imperfect	imperfect	ADJ
finefocus-5274	9	4	inverted	inverted	ADJ
finefocus-5274	9	5	repeats	repeat	NOUN
finefocus-5274	9	6	of	of	ADP
finefocus-5274	9	7	dna	dna	NOUN
finefocus-5274	9	8	that	that	PRON
finefocus-5274	9	9	can	can	AUX
finefocus-5274	9	10	give	give	VERB
finefocus-5274	9	11	rise	rise	NOUN
finefocus-5274	9	12	to	to	ADP
finefocus-5274	9	13	hairpins	hairpin	NOUN
finefocus-5274	9	14	and	and	CCONJ
finefocus-5274	9	15	cruciform	cruciform	PROPN
finefocus-5274	9	16	structures	structure	NOUN
finefocus-5274	9	17	.	.	PUNCT
finefocus-5274	10	1	dna	dna	PROPN
finefocus-5274	10	2	replication	replication	NOUN
finefocus-5274	10	3	and	and	CCONJ
finefocus-5274	10	4	gene	gene	NOUN
finefocus-5274	10	5	expression	expression	NOUN
finefocus-5274	10	6	are	be	AUX
finefocus-5274	10	7	fundamental	fundamental	ADJ
finefocus-5274	10	8	processes	process	NOUN
finefocus-5274	10	9	shared	share	VERB
finefocus-5274	10	10	by	by	ADP
finefocus-5274	10	11	all	all	DET
finefocus-5274	10	12	living	live	VERB
finefocus-5274	10	13	organisms	organism	NOUN
finefocus-5274	10	14	,	,	PUNCT
finefocus-5274	10	15	including	include	VERB
finefocus-5274	10	16	human	human	ADJ
finefocus-5274	10	17	cells	cell	NOUN
finefocus-5274	10	18	.	.	PUNCT
finefocus-5274	11	1	e.	e.	PROPN
finefocus-5274	11	2	coli	coli	PROPN
finefocus-5274	11	3	have	have	VERB
finefocus-5274	11	4	simpler	simple	ADJ
finefocus-5274	11	5	systems	system	NOUN
finefocus-5274	11	6	than	than	ADP
finefocus-5274	11	7	human	human	ADJ
finefocus-5274	11	8	cells	cell	NOUN
finefocus-5274	11	9	,	,	PUNCT
finefocus-5274	11	10	making	make	VERB
finefocus-5274	11	11	them	they	PRON
finefocus-5274	11	12	ideal	ideal	ADJ
finefocus-5274	11	13	for	for	ADP
finefocus-5274	11	14	preliminary	preliminary	ADJ
finefocus-5274	11	15	studies	study	NOUN
finefocus-5274	11	16	.	.	PUNCT
finefocus-5274	12	1	their	their	PRON
finefocus-5274	12	2	ease	ease	NOUN
finefocus-5274	12	3	of	of	ADP
finefocus-5274	12	4	genetic	genetic	ADJ
finefocus-5274	12	5	manipulation	manipulation	NOUN
finefocus-5274	12	6	and	and	CCONJ
finefocus-5274	12	7	rapid	rapid	ADJ
finefocus-5274	12	8	growth	growth	NOUN
finefocus-5274	12	9	in	in	ADP
finefocus-5274	12	10	the	the	DET
finefocus-5274	12	11	lab	lab	NOUN
finefocus-5274	12	12	further	far	ADV
finefocus-5274	12	13	enhance	enhance	VERB
finefocus-5274	12	14	their	their	PRON
finefocus-5274	12	15	utility	utility	NOUN
finefocus-5274	12	16	.	.	PUNCT
finefocus-5274	13	1	the	the	DET
finefocus-5274	13	2	thya	thya	NOUN
finefocus-5274	13	3	hotspot	hotspot	NOUN
finefocus-5274	13	4	in	in	ADP
finefocus-5274	13	5	e.	e.	PROPN
finefocus-5274	13	6	coli	coli	PROPN
finefocus-5274	13	7	was	be	AUX
finefocus-5274	13	8	the	the	DET
finefocus-5274	13	9	first	first	ADJ
finefocus-5274	13	10	natural	natural	ADJ
finefocus-5274	13	11	qp	qp	NOUN
finefocus-5274	13	12	hotspot	hotspot	NOUN
finefocus-5274	13	13	studied	study	VERB
finefocus-5274	13	14	for	for	ADP
finefocus-5274	13	15	mutagenesis	mutagenesis	NOUN
finefocus-5274	13	16	(	(	PUNCT
finefocus-5274	13	17	1	1	NUM
finefocus-5274	13	18	)	)	PUNCT
finefocus-5274	13	19	.	.	PUNCT
finefocus-5274	14	1	these	these	DET
finefocus-5274	14	2	structures	structure	NOUN
finefocus-5274	14	3	have	have	AUX
finefocus-5274	14	4	been	be	AUX
finefocus-5274	14	5	correlated	correlate	VERB
finefocus-5274	14	6	with	with	ADP
finefocus-5274	14	7	a	a	DET
finefocus-5274	14	8	specific	specific	ADJ
finefocus-5274	14	9	type	type	NOUN
finefocus-5274	14	10	of	of	ADP
finefocus-5274	14	11	mutation	mutation	NOUN
finefocus-5274	14	12	referred	refer	VERB
finefocus-5274	14	13	to	to	ADP
finefocus-5274	14	14	as	as	ADP
finefocus-5274	14	15	a	a	DET
finefocus-5274	14	16	template	template	NOUN
finefocus-5274	14	17	-	-	PUNCT
finefocus-5274	14	18	switch	switch	NOUN
finefocus-5274	14	19	mutation	mutation	NOUN
finefocus-5274	14	20	(	(	PUNCT
finefocus-5274	14	21	tsm	tsm	NOUN
finefocus-5274	14	22	)	)	PUNCT
finefocus-5274	14	23	.	.	PUNCT
finefocus-5274	15	1	tsms	tsm	NOUN
finefocus-5274	15	2	are	be	AUX
finefocus-5274	15	3	associated	associate	VERB
finefocus-5274	15	4	with	with	ADP
finefocus-5274	15	5	several	several	ADJ
finefocus-5274	15	6	human	human	ADJ
finefocus-5274	15	7	diseases	disease	NOUN
finefocus-5274	15	8	as	as	SCONJ
finefocus-5274	15	9	reviewed	review	VERB
finefocus-5274	15	10	(	(	PUNCT
finefocus-5274	15	11	2	2	NUM
finefocus-5274	15	12	)	)	PUNCT
finefocus-5274	15	13	,	,	PUNCT
finefocus-5274	15	14	including	include	VERB
finefocus-5274	15	15	hereditary	hereditary	ADJ
finefocus-5274	15	16	angioneurotic	angioneurotic	ADJ
finefocus-5274	15	17	edema	edema	NOUN
finefocus-5274	15	18	(	(	PUNCT
finefocus-5274	15	19	3	3	NUM
finefocus-5274	15	20	)	)	PUNCT
finefocus-5274	15	21	,	,	PUNCT
finefocus-5274	15	22	osteogenesis	osteogenesis	NOUN
finefocus-5274	15	23	imperfecta	imperfecta	NOUN
finefocus-5274	15	24	(	(	PUNCT
finefocus-5274	15	25	4	4	NUM
finefocus-5274	15	26	)	)	PUNCT
finefocus-5274	15	27	,	,	PUNCT
finefocus-5274	15	28	and	and	CCONJ
finefocus-5274	15	29	biotinidase	biotinidase	NOUN
finefocus-5274	15	30	deficiency	deficiency	NOUN
finefocus-5274	15	31	(	(	PUNCT
finefocus-5274	15	32	5	5	NUM
finefocus-5274	15	33	)	)	PUNCT
finefocus-5274	15	34	.	.	PUNCT
finefocus-5274	16	1	lynn	lynn	PROPN
finefocus-5274	16	2	ripley	ripley	PROPN
finefocus-5274	16	3	was	be	AUX
finefocus-5274	16	4	first	first	ADJ
finefocus-5274	16	5	to	to	PART
finefocus-5274	16	6	propose	propose	VERB
finefocus-5274	16	7	the	the	DET
finefocus-5274	16	8	two	two	NUM
finefocus-5274	16	9	mechanisms	mechanism	NOUN
finefocus-5274	16	10	for	for	ADP
finefocus-5274	16	11	qp	qp	ADV
finefocus-5274	16	12	-	-	PUNCT
finefocus-5274	16	13	induced	induce	VERB
finefocus-5274	16	14	tsm	tsm	NOUN
finefocus-5274	16	15	,	,	PUNCT
finefocus-5274	16	16	intramolecular	intramolecular	ADJ
finefocus-5274	16	17	and	and	CCONJ
finefocus-5274	16	18	intermolecular	intermolecular	ADJ
finefocus-5274	16	19	(	(	PUNCT
finefocus-5274	16	20	figure	figure	NOUN
finefocus-5274	16	21	1	1	NUM
finefocus-5274	16	22	)	)	PUNCT
finefocus-5274	16	23	,	,	PUNCT
finefocus-5274	16	24	both	both	PRON
finefocus-5274	16	25	of	of	ADP
finefocus-5274	16	26	which	which	PRON
finefocus-5274	16	27	can	can	AUX
finefocus-5274	16	28	involve	involve	VERB
finefocus-5274	16	29	a	a	DET
finefocus-5274	16	30	modification	modification	NOUN
finefocus-5274	16	31	of	of	ADP
finefocus-5274	16	32	the	the	DET
finefocus-5274	16	33	quasi	quasi	ADJ
finefocus-5274	16	34	-	-	ADJ
finefocus-5274	16	35	palindromic	palindromic	ADJ
finefocus-5274	16	36	region	region	NOUN
finefocus-5274	16	37	into	into	ADP
finefocus-5274	16	38	a	a	DET
finefocus-5274	16	39	perfected	perfect	VERB
finefocus-5274	16	40	palindrome	palindrome	NOUN
finefocus-5274	16	41	proposed	propose	VERB
finefocus-5274	16	42	to	to	PART
finefocus-5274	16	43	be	be	AUX
finefocus-5274	16	44	after	after	ADP
finefocus-5274	16	45	a	a	DET
finefocus-5274	16	46	momentary	momentary	ADJ
finefocus-5274	16	47	fork	fork	NOUN
finefocus-5274	16	48	stalling	stalling	NOUN
finefocus-5274	16	49	event	event	NOUN
finefocus-5274	16	50	.	.	PUNCT
finefocus-5274	17	1	(	(	PUNCT
finefocus-5274	17	2	6	6	NUM
finefocus-5274	17	3	)	)	PUNCT
finefocus-5274	17	4	while	while	SCONJ
finefocus-5274	17	5	tsm	tsm	NOUN
finefocus-5274	17	6	occurs	occur	VERB
finefocus-5274	17	7	on	on	ADP
finefocus-5274	17	8	both	both	PRON
finefocus-5274	17	9	leading	lead	VERB
finefocus-5274	17	10	and	and	CCONJ
finefocus-5274	17	11	lagging	lag	VERB
finefocus-5274	17	12	strands	strand	NOUN
finefocus-5274	17	13	during	during	ADP
finefocus-5274	17	14	dna	dna	PROPN
finefocus-5274	17	15	replication	replication	NOUN
finefocus-5274	17	16	,	,	PUNCT
finefocus-5274	17	17	the	the	DET
finefocus-5274	17	18	leading	lead	VERB
finefocus-5274	17	19	strand	strand	NOUN
finefocus-5274	17	20	exhibits	exhibit	VERB
finefocus-5274	17	21	a	a	DET
finefocus-5274	17	22	bias	bias	NOUN
finefocus-5274	17	23	towards	towards	ADP
finefocus-5274	17	24	tsm	tsm	NOUN
finefocus-5274	17	25	in	in	ADP
finefocus-5274	17	26	both	both	DET
finefocus-5274	17	27	reversion	reversion	NOUN
finefocus-5274	17	28	(	(	PUNCT
finefocus-5274	17	29	7	7	NUM
finefocus-5274	17	30	)	)	PUNCT
finefocus-5274	17	31	and	and	CCONJ
finefocus-5274	17	32	tsm	tsm	NOUN
finefocus-5274	17	33	-	-	PUNCT
finefocus-5274	17	34	specific	specific	ADJ
finefocus-5274	17	35	assays	assay	NOUN
finefocus-5274	17	36	(	(	PUNCT
finefocus-5274	17	37	8)	8)	NUM
finefocus-5274	17	38	.	.	PUNCT
finefocus-5274	18	1	this	this	DET
finefocus-5274	18	2	bias	bias	NOUN
finefocus-5274	18	3	is	be	AUX
finefocus-5274	18	4	nullified	nullify	VERB
finefocus-5274	18	5	in	in	ADP
finefocus-5274	18	6	the	the	DET
finefocus-5274	18	7	absence	absence	NOUN
finefocus-5274	18	8	of	of	ADP
finefocus-5274	18	9	exonucleases	exonuclease	NOUN
finefocus-5274	18	10	(	(	PUNCT
finefocus-5274	18	11	exoi	exoi	NOUN
finefocus-5274	18	12	and	and	CCONJ
finefocus-5274	18	13	exovii	exovii	ADJ
finefocus-5274	18	14	)	)	PUNCT
finefocus-5274	18	15	(	(	PUNCT
finefocus-5274	18	16	8)	8)	NUM
finefocus-5274	18	17	,	,	PUNCT
finefocus-5274	18	18	which	which	PRON
finefocus-5274	18	19	are	be	AUX
finefocus-5274	18	20	known	know	VERB
finefocus-5274	18	21	to	to	PART
finefocus-5274	18	22	prevent	prevent	VERB
finefocus-5274	18	23	tsm	tsm	NOUN
finefocus-5274	18	24	(	(	PUNCT
finefocus-5274	18	25	1	1	NUM
finefocus-5274	18	26	,	,	PUNCT
finefocus-5274	18	27	9	9	NUM
finefocus-5274	18	28	)	)	PUNCT
finefocus-5274	18	29	with	with	ADP
finefocus-5274	18	30	exoi	exoi	NOUN
finefocus-5274	18	31	playing	play	VERB
finefocus-5274	18	32	the	the	DET
finefocus-5274	18	33	larger	large	ADJ
finefocus-5274	18	34	role	role	NOUN
finefocus-5274	18	35	(	(	PUNCT
finefocus-5274	18	36	1	1	NUM
finefocus-5274	18	37	)	)	PUNCT
finefocus-5274	18	38	.	.	PUNCT
finefocus-5274	19	1	this	this	PRON
finefocus-5274	19	2	suggests	suggest	VERB
finefocus-5274	19	3	that	that	SCONJ
finefocus-5274	19	4	both	both	DET
finefocus-5274	19	5	strands	strand	NOUN
finefocus-5274	19	6	can	can	AUX
finefocus-5274	19	7	undergo	undergo	VERB
finefocus-5274	19	8	mutations	mutation	NOUN
finefocus-5274	19	9	,	,	PUNCT
finefocus-5274	19	10	abstract	abstract	ADJ
finefocus-5274	19	11	quasipalindromes	quasipalindrome	NOUN
finefocus-5274	19	12	(	(	PUNCT
finefocus-5274	19	13	qps	qps	NOUN
finefocus-5274	19	14	)	)	PUNCT
finefocus-5274	19	15	are	be	AUX
finefocus-5274	19	16	dna	dna	PROPN
finefocus-5274	19	17	sequences	sequence	NOUN
finefocus-5274	19	18	that	that	PRON
finefocus-5274	19	19	are	be	AUX
finefocus-5274	19	20	imperfectly	imperfectly	ADV
finefocus-5274	19	21	mirrored	mirror	VERB
finefocus-5274	19	22	,	,	PUNCT
finefocus-5274	19	23	known	know	VERB
finefocus-5274	19	24	to	to	PART
finefocus-5274	19	25	form	form	VERB
finefocus-5274	19	26	secondary	secondary	ADJ
finefocus-5274	19	27	structures	structure	NOUN
finefocus-5274	19	28	like	like	ADP
finefocus-5274	19	29	hairpins	hairpin	NOUN
finefocus-5274	19	30	and	and	CCONJ
finefocus-5274	19	31	cruciforms	cruciform	NOUN
finefocus-5274	19	32	.	.	PUNCT
finefocus-5274	20	1	these	these	DET
finefocus-5274	20	2	sites	site	NOUN
finefocus-5274	20	3	have	have	AUX
finefocus-5274	20	4	been	be	AUX
finefocus-5274	20	5	linked	link	VERB
finefocus-5274	20	6	with	with	ADP
finefocus-5274	20	7	a	a	DET
finefocus-5274	20	8	specific	specific	ADJ
finefocus-5274	20	9	type	type	NOUN
finefocus-5274	20	10	of	of	ADP
finefocus-5274	20	11	mutation	mutation	NOUN
finefocus-5274	20	12	called	call	VERB
finefocus-5274	20	13	template	template	NOUN
finefocus-5274	20	14	-	-	PUNCT
finefocus-5274	20	15	switch	switch	NOUN
finefocus-5274	20	16	mutation	mutation	NOUN
finefocus-5274	20	17	(	(	PUNCT
finefocus-5274	20	18	tsm	tsm	NOUN
finefocus-5274	20	19	)	)	PUNCT
finefocus-5274	20	20	.	.	PUNCT
finefocus-5274	21	1	certain	certain	ADJ
finefocus-5274	21	2	drugs	drug	NOUN
finefocus-5274	21	3	like	like	ADP
finefocus-5274	21	4	5	5	NUM
finefocus-5274	21	5	-	-	PUNCT
finefocus-5274	21	6	azacytidine	azacytidine	NOUN
finefocus-5274	21	7	,	,	PUNCT
finefocus-5274	21	8	azidothymidine	azidothymidine	NOUN
finefocus-5274	21	9	(	(	PUNCT
finefocus-5274	21	10	azt	azt	PROPN
finefocus-5274	21	11	)	)	PUNCT
finefocus-5274	21	12	,	,	PUNCT
finefocus-5274	21	13	and	and	CCONJ
finefocus-5274	21	14	ciprofloxacin	ciprofloxacin	PROPN
finefocus-5274	21	15	are	be	AUX
finefocus-5274	21	16	known	know	VERB
finefocus-5274	21	17	to	to	PART
finefocus-5274	21	18	induce	induce	VERB
finefocus-5274	21	19	tsm	tsm	NOUN
finefocus-5274	21	20	.	.	PUNCT
finefocus-5274	22	1	this	this	DET
finefocus-5274	22	2	study	study	NOUN
finefocus-5274	22	3	aims	aim	VERB
finefocus-5274	22	4	to	to	PART
finefocus-5274	22	5	assess	assess	VERB
finefocus-5274	22	6	the	the	DET
finefocus-5274	22	7	impact	impact	NOUN
finefocus-5274	22	8	of	of	ADP
finefocus-5274	22	9	five	five	NUM
finefocus-5274	22	10	fda	fda	PROPN
finefocus-5274	22	11	-	-	PUNCT
finefocus-5274	22	12	approved	approve	VERB
finefocus-5274	22	13	drugs	drug	NOUN
finefocus-5274	22	14	—	—	PUNCT
finefocus-5274	22	15	three	three	NUM
finefocus-5274	22	16	antitumor	antitumor	PROPN
finefocus-5274	22	17	drugs	drug	NOUN
finefocus-5274	22	18	(	(	PUNCT
finefocus-5274	22	19	cpt-11	cpt-11	PROPN
finefocus-5274	22	20	,	,	PUNCT
finefocus-5274	22	21	doxorubicin	doxorubicin	ADJ
finefocus-5274	22	22	hydrochloride	hydrochloride	NOUN
finefocus-5274	22	23	,	,	PUNCT
finefocus-5274	22	24	and	and	CCONJ
finefocus-5274	22	25	gemcitabine	gemcitabine	NOUN
finefocus-5274	22	26	hydrochloride	hydrochloride	NOUN
finefocus-5274	22	27	)	)	PUNCT
finefocus-5274	22	28	and	and	CCONJ
finefocus-5274	22	29	two	two	NUM
finefocus-5274	22	30	anti	anti	ADJ
finefocus-5274	22	31	-	-	NOUN
finefocus-5274	22	32	inflammatories	inflammatorie	NOUN
finefocus-5274	22	33	(	(	PUNCT
finefocus-5274	22	34	ibuprofen	ibuprofen	NOUN
finefocus-5274	22	35	and	and	CCONJ
finefocus-5274	22	36	dexamethasone)—on	dexamethasone)—on	NOUN
finefocus-5274	22	37	template	template	NOUN
finefocus-5274	22	38	-	-	PUNCT
finefocus-5274	22	39	switch	switch	NOUN
finefocus-5274	22	40	mutagenesis	mutagenesis	NOUN
finefocus-5274	22	41	.	.	PUNCT
finefocus-5274	23	1	studying	study	VERB
finefocus-5274	23	2	fda	fda	PROPN
finefocus-5274	23	3	-	-	PUNCT
finefocus-5274	23	4	approved	approve	VERB
finefocus-5274	23	5	drugs	drug	NOUN
finefocus-5274	23	6	for	for	ADP
finefocus-5274	23	7	their	their	PRON
finefocus-5274	23	8	impact	impact	NOUN
finefocus-5274	23	9	on	on	ADP
finefocus-5274	23	10	tsm	tsm	NOUN
finefocus-5274	23	11	is	be	AUX
finefocus-5274	23	12	important	important	ADJ
finefocus-5274	23	13	,	,	PUNCT
finefocus-5274	23	14	as	as	SCONJ
finefocus-5274	23	15	they	they	PRON
finefocus-5274	23	16	are	be	AUX
finefocus-5274	23	17	associated	associate	VERB
finefocus-5274	23	18	with	with	ADP
finefocus-5274	23	19	diseases	disease	NOUN
finefocus-5274	23	20	like	like	ADP
finefocus-5274	23	21	hereditary	hereditary	ADJ
finefocus-5274	23	22	angioneurotic	angioneurotic	ADJ
finefocus-5274	23	23	edema	edema	NOUN
finefocus-5274	23	24	,	,	PUNCT
finefocus-5274	23	25	osteogenesis	osteogenesis	NOUN
finefocus-5274	23	26	imperfecta	imperfecta	NOUN
finefocus-5274	23	27	,	,	PUNCT
finefocus-5274	23	28	and	and	CCONJ
finefocus-5274	23	29	biotinidase	biotinidase	NOUN
finefocus-5274	23	30	deficiency	deficiency	NOUN
finefocus-5274	23	31	.	.	PUNCT
finefocus-5274	24	1	the	the	DET
finefocus-5274	24	2	findings	finding	NOUN
finefocus-5274	24	3	reveal	reveal	VERB
finefocus-5274	24	4	no	no	DET
finefocus-5274	24	5	statistically	statistically	ADV
finefocus-5274	24	6	significant	significant	ADJ
finefocus-5274	24	7	effects	effect	NOUN
finefocus-5274	24	8	on	on	ADP
finefocus-5274	24	9	frequency	frequency	NOUN
finefocus-5274	24	10	of	of	ADP
finefocus-5274	24	11	mutations	mutation	NOUN
finefocus-5274	24	12	after	after	ADP
finefocus-5274	24	13	treatment	treatment	NOUN
finefocus-5274	24	14	with	with	ADP
finefocus-5274	24	15	gemcitabine	gemcitabine	NOUN
finefocus-5274	24	16	hydrochloride	hydrochloride	NOUN
finefocus-5274	24	17	,	,	PUNCT
finefocus-5274	24	18	ibuprofen	ibuprofen	NOUN
finefocus-5274	24	19	,	,	PUNCT
finefocus-5274	24	20	dexamethasone	dexamethasone	NOUN
finefocus-5274	24	21	,	,	PUNCT
finefocus-5274	24	22	or	or	CCONJ
finefocus-5274	24	23	doxorubicin	doxorubicin	PROPN
finefocus-5274	24	24	hydrochloride	hydrochloride	NOUN
finefocus-5274	24	25	.	.	PUNCT
finefocus-5274	25	1	however	however	ADV
finefocus-5274	25	2	,	,	PUNCT
finefocus-5274	25	3	cpt-11	cpt-11	NUM
finefocus-5274	25	4	treatment	treatment	NOUN
finefocus-5274	25	5	showed	show	VERB
finefocus-5274	25	6	a	a	DET
finefocus-5274	25	7	notable	notable	ADJ
finefocus-5274	25	8	decrease	decrease	NOUN
finefocus-5274	25	9	in	in	ADP
finefocus-5274	25	10	tsm	tsm	NOUN
finefocus-5274	25	11	,	,	PUNCT
finefocus-5274	25	12	suggesting	suggest	VERB
finefocus-5274	25	13	a	a	DET
finefocus-5274	25	14	potential	potential	ADJ
finefocus-5274	25	15	role	role	NOUN
finefocus-5274	25	16	in	in	ADP
finefocus-5274	25	17	disrupting	disrupt	VERB
finefocus-5274	25	18	the	the	DET
finefocus-5274	25	19	template	template	NOUN
finefocus-5274	25	20	-	-	PUNCT
finefocus-5274	25	21	switching	switch	VERB
finefocus-5274	25	22	process	process	NOUN
finefocus-5274	25	23	.	.	PUNCT
finefocus-5274	26	1	keywords	keyword	NOUN
finefocus-5274	26	2	:	:	PUNCT
finefocus-5274	26	3	quasi	quasi	ADJ
finefocus-5274	26	4	-	-	PUNCT
finefocus-5274	26	5	palindrome	palindrome	ADJ
finefocus-5274	26	6	;	;	PUNCT
finefocus-5274	26	7	mutagenesis	mutagenesis	NOUN
finefocus-5274	26	8	;	;	PUNCT
finefocus-5274	26	9	dna	dna	NOUN
finefocus-5274	26	10	replication	replication	NOUN
finefocus-5274	26	11	inhibitors	inhibitor	NOUN
finefocus-5274	26	12	;	;	PUNCT
finefocus-5274	26	13	dna	dna	PROPN
finefocus-5274	26	14	repair	repair	VERB
finefocus-5274	26	15	corresponding	corresponding	ADJ
finefocus-5274	26	16	author	author	NOUN
finefocus-5274	26	17	email	email	NOUN
finefocus-5274	26	18	:	:	PUNCT
finefocus-5274	26	19	aswain@student.framingham.edu	aswain@student.framingham.edu	PROPN
finefocus-5274	26	20	manuscript	manuscript	NOUN
finefocus-5274	26	21	received	receive	VERB
finefocus-5274	26	22	24	24	NUM
finefocus-5274	26	23	april	april	PROPN
finefocus-5274	26	24	2024	2024	NUM
finefocus-5274	26	25	;	;	PUNCT
finefocus-5274	26	26	accepted	accept	VERB
finefocus-5274	26	27	30	30	NUM
finefocus-5274	26	28	january	january	NOUN
finefocus-5274	26	29	2025	2025	NUM
finefocus-5274	26	30	mailto:aswain@student.framingham.edu	mailto:aswain@student.framingham.edu	PROPN
finefocus-5274	26	31	fine	fine	ADJ
finefocus-5274	26	32	focus	focus	NOUN
finefocus-5274	26	33	|	|	ADV
finefocus-5274	26	34	volume	volume	NOUN
finefocus-5274	26	35	1114	1114	NUM
finefocus-5274	26	36	but	but	CCONJ
finefocus-5274	26	37	the	the	DET
finefocus-5274	26	38	lagging	lag	VERB
finefocus-5274	26	39	strand	strand	NOUN
finefocus-5274	26	40	is	be	AUX
finefocus-5274	26	41	more	more	ADV
finefocus-5274	26	42	adept	adept	ADJ
finefocus-5274	26	43	at	at	ADP
finefocus-5274	26	44	averting	avert	VERB
finefocus-5274	26	45	and	and	CCONJ
finefocus-5274	26	46	correcting	correct	VERB
finefocus-5274	26	47	them	they	PRON
finefocus-5274	26	48	(	(	PUNCT
finefocus-5274	26	49	8)	8)	NUM
finefocus-5274	26	50	.	.	PUNCT
finefocus-5274	26	51	additionally	additionally	ADV
finefocus-5274	26	52	,	,	PUNCT
finefocus-5274	26	53	research	research	NOUN
finefocus-5274	26	54	has	have	AUX
finefocus-5274	26	55	demonstrated	demonstrate	VERB
finefocus-5274	26	56	that	that	DET
finefocus-5274	26	57	exposure	exposure	NOUN
finefocus-5274	26	58	of	of	ADP
finefocus-5274	26	59	qp	qp	ADP
finefocus-5274	26	60	sites	site	NOUN
finefocus-5274	26	61	to	to	ADP
finefocus-5274	26	62	chemicals	chemical	NOUN
finefocus-5274	26	63	can	can	AUX
finefocus-5274	26	64	influence	influence	VERB
finefocus-5274	26	65	the	the	DET
finefocus-5274	26	66	rate	rate	NOUN
finefocus-5274	26	67	of	of	ADP
finefocus-5274	26	68	tsm	tsm	NOUN
finefocus-5274	26	69	(	(	PUNCT
finefocus-5274	26	70	10	10	NUM
finefocus-5274	26	71	,	,	PUNCT
finefocus-5274	26	72	11	11	NUM
finefocus-5274	26	73	)	)	PUNCT
finefocus-5274	26	74	.	.	PUNCT
finefocus-5274	27	1	azidothymidine	azidothymidine	NOUN
finefocus-5274	27	2	(	(	PUNCT
finefocus-5274	27	3	azt	azt	PROPN
finefocus-5274	27	4	)	)	PUNCT
finefocus-5274	27	5	,	,	PUNCT
finefocus-5274	27	6	a	a	DET
finefocus-5274	27	7	thymidine	thymidine	ADJ
finefocus-5274	27	8	analogue	analogue	NOUN
finefocus-5274	27	9	used	use	VERB
finefocus-5274	27	10	as	as	ADP
finefocus-5274	27	11	an	an	DET
finefocus-5274	27	12	antiretroviral	antiretroviral	ADJ
finefocus-5274	27	13	medication	medication	NOUN
finefocus-5274	27	14	to	to	PART
finefocus-5274	27	15	prevent	prevent	VERB
finefocus-5274	27	16	and	and	CCONJ
finefocus-5274	27	17	treat	treat	VERB
finefocus-5274	27	18	hiv	hiv	PROPN
finefocus-5274	27	19	/	/	SYM
finefocus-5274	27	20	aids	aids	PROPN
finefocus-5274	27	21	,	,	PUNCT
finefocus-5274	27	22	has	have	AUX
finefocus-5274	27	23	been	be	AUX
finefocus-5274	27	24	seen	see	VERB
finefocus-5274	27	25	to	to	PART
finefocus-5274	27	26	increase	increase	VERB
finefocus-5274	27	27	tsm	tsm	NOUN
finefocus-5274	27	28	rates	rate	NOUN
finefocus-5274	27	29	(	(	PUNCT
finefocus-5274	27	30	11	11	NUM
finefocus-5274	27	31	)	)	PUNCT
finefocus-5274	27	32	.	.	PUNCT
finefocus-5274	28	1	other	other	ADJ
finefocus-5274	28	2	drugs	drug	NOUN
finefocus-5274	28	3	found	find	VERB
finefocus-5274	28	4	to	to	PART
finefocus-5274	28	5	increase	increase	VERB
finefocus-5274	28	6	rates	rate	NOUN
finefocus-5274	28	7	of	of	ADP
finefocus-5274	28	8	tsm	tsm	NOUN
finefocus-5274	28	9	include	include	VERB
finefocus-5274	28	10	5	5	NUM
finefocus-5274	28	11	-	-	PUNCT
finefocus-5274	28	12	azacytidine	azacytidine	NOUN
finefocus-5274	28	13	(	(	PUNCT
finefocus-5274	28	14	5	5	NUM
finefocus-5274	28	15	-	-	PUNCT
finefocus-5274	28	16	azac	azac	NOUN
finefocus-5274	28	17	)	)	PUNCT
finefocus-5274	28	18	,	,	PUNCT
finefocus-5274	28	19	the	the	DET
finefocus-5274	28	20	antibiotic	antibiotic	ADJ
finefocus-5274	28	21	ciprofloxacin	ciprofloxacin	NOUN
finefocus-5274	28	22	,	,	PUNCT
finefocus-5274	28	23	and	and	CCONJ
finefocus-5274	28	24	formaldehyde	formaldehyde	NOUN
finefocus-5274	28	25	(	(	PUNCT
finefocus-5274	28	26	10	10	NUM
finefocus-5274	28	27	)	)	PUNCT
finefocus-5274	28	28	.	.	PUNCT
finefocus-5274	29	1	5	5	NUM
finefocus-5274	29	2	-	-	PUNCT
finefocus-5274	29	3	azac	azac	NOUN
finefocus-5274	29	4	interacts	interact	VERB
finefocus-5274	29	5	with	with	ADP
finefocus-5274	29	6	cytosine	cytosine	NOUN
finefocus-5274	29	7	methyltransferase	methyltransferase	NOUN
finefocus-5274	29	8	(	(	PUNCT
finefocus-5274	29	9	12	12	NUM
finefocus-5274	29	10	)	)	PUNCT
finefocus-5274	29	11	to	to	PART
finefocus-5274	29	12	cause	cause	VERB
finefocus-5274	29	13	dna	dna	NOUN
finefocus-5274	29	14	/	/	SYM
finefocus-5274	29	15	protein	protein	NOUN
finefocus-5274	29	16	crosslinks	crosslink	NOUN
finefocus-5274	29	17	that	that	PRON
finefocus-5274	29	18	stall	stall	VERB
finefocus-5274	29	19	replication	replication	NOUN
finefocus-5274	29	20	(	(	PUNCT
finefocus-5274	29	21	13	13	NUM
finefocus-5274	29	22	)	)	PUNCT
finefocus-5274	29	23	,	,	PUNCT
finefocus-5274	29	24	the	the	DET
finefocus-5274	29	25	antibiotic	antibiotic	ADJ
finefocus-5274	29	26	ciprofloxacin	ciprofloxacin	NOUN
finefocus-5274	29	27	is	be	AUX
finefocus-5274	29	28	a	a	DET
finefocus-5274	29	29	topoisomerase	topoisomerase	ADJ
finefocus-5274	29	30	type	type	NOUN
finefocus-5274	29	31	ii	ii	NOUN
finefocus-5274	29	32	inhibitor	inhibitor	NOUN
finefocus-5274	29	33	,	,	PUNCT
finefocus-5274	29	34	like	like	ADP
finefocus-5274	29	35	dna	dna	NOUN
finefocus-5274	29	36	gyrase	gyrase	NOUN
finefocus-5274	29	37	(	(	PUNCT
finefocus-5274	29	38	14	14	NUM
finefocus-5274	29	39	)	)	PUNCT
finefocus-5274	29	40	and	and	CCONJ
finefocus-5274	29	41	the	the	DET
finefocus-5274	29	42	chemical	chemical	NOUN
finefocus-5274	29	43	formaldehyde	formaldehyde	NOUN
finefocus-5274	29	44	acts	act	VERB
finefocus-5274	29	45	as	as	ADP
finefocus-5274	29	46	a	a	DET
finefocus-5274	29	47	general	general	ADJ
finefocus-5274	29	48	mutagen	mutagen	NOUN
finefocus-5274	29	49	,	,	PUNCT
finefocus-5274	29	50	including	include	VERB
finefocus-5274	29	51	creating	create	VERB
finefocus-5274	29	52	dna/	dna/	ADJ
finefocus-5274	29	53	protein	protein	NOUN
finefocus-5274	29	54	crosslinks	crosslink	NOUN
finefocus-5274	29	55	in	in	ADP
finefocus-5274	29	56	human	human	ADJ
finefocus-5274	29	57	cells	cell	NOUN
finefocus-5274	29	58	(	(	PUNCT
finefocus-5274	29	59	15	15	NUM
finefocus-5274	29	60	)	)	PUNCT
finefocus-5274	29	61	.	.	PUNCT
finefocus-5274	30	1	this	this	DET
finefocus-5274	30	2	study	study	NOUN
finefocus-5274	30	3	focuses	focus	VERB
finefocus-5274	30	4	on	on	ADP
finefocus-5274	30	5	testing	test	VERB
finefocus-5274	30	6	additional	additional	ADJ
finefocus-5274	30	7	fda	fda	PROPN
finefocus-5274	30	8	-	-	PUNCT
finefocus-5274	30	9	approved	approve	VERB
finefocus-5274	30	10	drugs	drug	NOUN
finefocus-5274	30	11	,	,	PUNCT
finefocus-5274	30	12	described	describe	VERB
finefocus-5274	30	13	below	below	ADV
finefocus-5274	30	14	,	,	PUNCT
finefocus-5274	30	15	for	for	ADP
finefocus-5274	30	16	their	their	PRON
finefocus-5274	30	17	impact	impact	NOUN
finefocus-5274	30	18	on	on	ADP
finefocus-5274	30	19	tsm	tsm	NOUN
finefocus-5274	30	20	frequency	frequency	NOUN
finefocus-5274	30	21	in	in	ADP
finefocus-5274	30	22	e.	e.	PROPN
finefocus-5274	30	23	coli	coli	PROPN
finefocus-5274	30	24	.	.	PUNCT
finefocus-5274	31	1	a	a	DET
finefocus-5274	31	2	mutational	mutational	ADJ
finefocus-5274	31	3	reporter	reporter	NOUN
finefocus-5274	31	4	in	in	ADP
finefocus-5274	31	5	the	the	DET
finefocus-5274	31	6	lacz	lacz	NOUN
finefocus-5274	31	7	gene	gene	NOUN
finefocus-5274	31	8	of	of	ADP
finefocus-5274	31	9	e.	e.	PROPN
finefocus-5274	31	10	coli	coli	PROPN
finefocus-5274	31	11	has	have	AUX
finefocus-5274	31	12	been	be	AUX
finefocus-5274	31	13	used	use	VERB
finefocus-5274	31	14	to	to	PART
finefocus-5274	31	15	identify	identify	VERB
finefocus-5274	31	16	the	the	DET
finefocus-5274	31	17	rate	rate	NOUN
finefocus-5274	31	18	of	of	ADP
finefocus-5274	31	19	quasi	quasi	ADJ
finefocus-5274	31	20	-	-	ADJ
finefocus-5274	31	21	palindrome	palindrome	ADJ
finefocus-5274	31	22	mutations	mutation	NOUN
finefocus-5274	31	23	after	after	ADP
finefocus-5274	31	24	exposure	exposure	NOUN
finefocus-5274	31	25	to	to	ADP
finefocus-5274	31	26	various	various	ADJ
finefocus-5274	31	27	fda	fda	PROPN
finefocus-5274	31	28	-	-	PUNCT
finefocus-5274	31	29	approved	approve	VERB
finefocus-5274	31	30	drugs	drug	NOUN
finefocus-5274	31	31	.	.	PUNCT
finefocus-5274	32	1	these	these	DET
finefocus-5274	32	2	mutations	mutation	NOUN
finefocus-5274	32	3	become	become	VERB
finefocus-5274	32	4	apparent	apparent	ADJ
finefocus-5274	32	5	when	when	SCONJ
finefocus-5274	32	6	lacz	lacz	NOUN
finefocus-5274	32	7	alleles	allele	NOUN
finefocus-5274	32	8	revert	revert	ADJ
finefocus-5274	32	9	to	to	ADP
finefocus-5274	32	10	lac+	lac+	PROPN
finefocus-5274	32	11	,	,	PUNCT
finefocus-5274	32	12	a	a	DET
finefocus-5274	32	13	phenomenon	phenomenon	NOUN
finefocus-5274	32	14	observed	observe	VERB
finefocus-5274	32	15	only	only	ADV
finefocus-5274	32	16	if	if	SCONJ
finefocus-5274	32	17	a	a	DET
finefocus-5274	32	18	template	template	NOUN
finefocus-5274	32	19	-	-	PUNCT
finefocus-5274	32	20	switch	switch	NOUN
finefocus-5274	32	21	event	event	NOUN
finefocus-5274	32	22	occurs	occur	VERB
finefocus-5274	32	23	.	.	PUNCT
finefocus-5274	33	1	additionally	additionally	ADV
finefocus-5274	33	2	,	,	PUNCT
finefocus-5274	33	3	since	since	SCONJ
finefocus-5274	33	4	most	most	ADJ
finefocus-5274	33	5	studies	study	NOUN
finefocus-5274	33	6	on	on	ADP
finefocus-5274	33	7	the	the	DET
finefocus-5274	33	8	influence	influence	NOUN
finefocus-5274	33	9	of	of	ADP
finefocus-5274	33	10	drug	drug	NOUN
finefocus-5274	33	11	exposure	exposure	NOUN
finefocus-5274	33	12	on	on	ADP
finefocus-5274	33	13	tsm	tsm	NOUN
finefocus-5274	33	14	have	have	AUX
finefocus-5274	33	15	also	also	ADV
finefocus-5274	33	16	used	use	VERB
finefocus-5274	33	17	this	this	DET
finefocus-5274	33	18	mutational	mutational	ADJ
finefocus-5274	33	19	reporter	reporter	NOUN
finefocus-5274	33	20	in	in	ADP
finefocus-5274	33	21	e.	e.	PROPN
finefocus-5274	33	22	coli	coli	PROPN
finefocus-5274	33	23	,	,	PUNCT
finefocus-5274	33	24	continuing	continue	VERB
finefocus-5274	33	25	to	to	PART
finefocus-5274	33	26	use	use	VERB
finefocus-5274	33	27	this	this	DET
finefocus-5274	33	28	system	system	NOUN
finefocus-5274	33	29	allows	allow	VERB
finefocus-5274	33	30	for	for	ADP
finefocus-5274	33	31	consistent	consistent	ADJ
finefocus-5274	33	32	and	and	CCONJ
finefocus-5274	33	33	fair	fair	ADJ
finefocus-5274	33	34	comparisons	comparison	NOUN
finefocus-5274	33	35	across	across	ADP
finefocus-5274	33	36	research	research	NOUN
finefocus-5274	33	37	.	.	PUNCT
finefocus-5274	34	1	all	all	DET
finefocus-5274	34	2	the	the	DET
finefocus-5274	34	3	fda	fda	PROPN
finefocus-5274	34	4	-	-	PUNCT
finefocus-5274	34	5	approved	approve	VERB
finefocus-5274	34	6	therapeutics	therapeutic	NOUN
finefocus-5274	34	7	selected	select	VERB
finefocus-5274	34	8	have	have	VERB
finefocus-5274	34	9	at	at	ADV
finefocus-5274	34	10	least	least	ADV
finefocus-5274	34	11	one	one	NUM
finefocus-5274	34	12	mechanism	mechanism	NOUN
finefocus-5274	34	13	of	of	ADP
finefocus-5274	34	14	action	action	NOUN
finefocus-5274	34	15	capable	capable	ADJ
finefocus-5274	34	16	of	of	ADP
finefocus-5274	34	17	causing	cause	VERB
finefocus-5274	34	18	replication	replication	NOUN
finefocus-5274	34	19	fork	fork	NOUN
finefocus-5274	34	20	stalling	stalling	NOUN
finefocus-5274	34	21	,	,	PUNCT
finefocus-5274	34	22	a	a	DET
finefocus-5274	34	23	necessary	necessary	ADJ
finefocus-5274	34	24	condition	condition	NOUN
finefocus-5274	34	25	for	for	ADP
finefocus-5274	34	26	both	both	DET
finefocus-5274	34	27	intraand	intraand	ADV
finefocus-5274	34	28	intermolecular	intermolecular	ADJ
finefocus-5274	34	29	tsm	tsm	NOUN
finefocus-5274	34	30	.	.	PUNCT
finefocus-5274	35	1	it	it	PRON
finefocus-5274	35	2	is	be	AUX
finefocus-5274	35	3	expected	expect	VERB
finefocus-5274	35	4	that	that	SCONJ
finefocus-5274	35	5	these	these	DET
finefocus-5274	35	6	drugs	drug	NOUN
finefocus-5274	35	7	are	be	AUX
finefocus-5274	35	8	either	either	CCONJ
finefocus-5274	35	9	inhibiting	inhibit	VERB
finefocus-5274	35	10	a	a	DET
finefocus-5274	35	11	process	process	NOUN
finefocus-5274	35	12	during	during	ADP
finefocus-5274	35	13	dna	dna	NOUN
finefocus-5274	35	14	replication	replication	NOUN
finefocus-5274	35	15	or	or	CCONJ
finefocus-5274	35	16	disrupting	disrupt	VERB
finefocus-5274	35	17	dna	dna	NOUN
finefocus-5274	35	18	through	through	ADP
finefocus-5274	35	19	intercalation	intercalation	NOUN
finefocus-5274	35	20	and	and	CCONJ
finefocus-5274	35	21	will	will	AUX
finefocus-5274	35	22	lead	lead	VERB
finefocus-5274	35	23	to	to	ADP
finefocus-5274	35	24	an	an	DET
finefocus-5274	35	25	increase	increase	NOUN
finefocus-5274	35	26	in	in	ADP
finefocus-5274	35	27	tsm	tsm	NOUN
finefocus-5274	35	28	frequency	frequency	NOUN
finefocus-5274	35	29	.	.	PUNCT
finefocus-5274	36	1	figure	figure	NOUN
finefocus-5274	36	2	1	1	NUM
finefocus-5274	36	3	.	.	PUNCT
finefocus-5274	37	1	quasi	quasi	ADJ
finefocus-5274	37	2	-	-	ADJ
finefocus-5274	37	3	palindrome	palindrome	ADJ
finefocus-5274	37	4	template	template	NOUN
finefocus-5274	37	5	-	-	PUNCT
finefocus-5274	37	6	switch	switch	NOUN
finefocus-5274	37	7	mutation	mutation	NOUN
finefocus-5274	37	8	mechanisms	mechanism	VERB
finefocus-5274	37	9	two	two	NUM
finefocus-5274	37	10	template	template	NOUN
finefocus-5274	37	11	-	-	PUNCT
finefocus-5274	37	12	switch	switch	NOUN
finefocus-5274	37	13	mutation	mutation	NOUN
finefocus-5274	37	14	models	model	NOUN
finefocus-5274	37	15	involving	involve	VERB
finefocus-5274	37	16	a	a	DET
finefocus-5274	37	17	temporary	temporary	ADJ
finefocus-5274	37	18	displacement	displacement	NOUN
finefocus-5274	37	19	of	of	ADP
finefocus-5274	37	20	the	the	DET
finefocus-5274	37	21	nascent	nascent	NOUN
finefocus-5274	37	22	strand	strand	NOUN
finefocus-5274	37	23	and	and	CCONJ
finefocus-5274	37	24	relocation	relocation	NOUN
finefocus-5274	37	25	of	of	ADP
finefocus-5274	37	26	the	the	DET
finefocus-5274	37	27	polymerase	polymerase	NOUN
finefocus-5274	37	28	onto	onto	ADP
finefocus-5274	37	29	another	another	DET
finefocus-5274	37	30	strand	strand	NOUN
finefocus-5274	37	31	different	different	ADJ
finefocus-5274	37	32	from	from	ADP
finefocus-5274	37	33	the	the	DET
finefocus-5274	37	34	original	original	ADJ
finefocus-5274	37	35	template	template	NOUN
finefocus-5274	37	36	.	.	PUNCT
finefocus-5274	38	1	in	in	ADP
finefocus-5274	38	2	the	the	DET
finefocus-5274	38	3	intramolecular	intramolecular	ADJ
finefocus-5274	38	4	model	model	NOUN
finefocus-5274	38	5	,	,	PUNCT
finefocus-5274	38	6	the	the	DET
finefocus-5274	38	7	nascent	nascent	NOUN
finefocus-5274	38	8	strand	strand	NOUN
finefocus-5274	38	9	becomes	become	VERB
finefocus-5274	38	10	the	the	DET
finefocus-5274	38	11	template	template	NOUN
finefocus-5274	38	12	,	,	PUNCT
finefocus-5274	38	13	in	in	ADP
finefocus-5274	38	14	the	the	DET
finefocus-5274	38	15	intermolecular	intermolecular	ADJ
finefocus-5274	38	16	model	model	NOUN
finefocus-5274	38	17	,	,	PUNCT
finefocus-5274	38	18	the	the	DET
finefocus-5274	38	19	homologous	homologous	ADJ
finefocus-5274	38	20	strand	strand	NOUN
finefocus-5274	38	21	becomes	become	VERB
finefocus-5274	38	22	the	the	DET
finefocus-5274	38	23	template	template	NOUN
finefocus-5274	38	24	.	.	PUNCT
finefocus-5274	39	1	both	both	DET
finefocus-5274	39	2	mechanisms	mechanism	NOUN
finefocus-5274	39	3	created	create	VERB
finefocus-5274	39	4	a	a	DET
finefocus-5274	39	5	situation	situation	NOUN
finefocus-5274	39	6	that	that	PRON
finefocus-5274	39	7	can	can	AUX
finefocus-5274	39	8	perfect	perfect	VERB
finefocus-5274	39	9	an	an	DET
finefocus-5274	39	10	imperfect	imperfect	ADJ
finefocus-5274	39	11	palindrome	palindrome	NOUN
finefocus-5274	39	12	.	.	PUNCT
finefocus-5274	40	1	(	(	PUNCT
finefocus-5274	40	2	created	create	VERB
finefocus-5274	40	3	in	in	ADP
finefocus-5274	40	4	https://biorender.com	https://biorender.com	X
finefocus-5274	40	5	)	)	PUNCT
finefocus-5274	40	6	https://biorender.com	https://biorender.com	X
finefocus-5274	40	7	swain	swain	PROPN
finefocus-5274	40	8	et	et	PROPN
finefocus-5274	40	9	al	al	PROPN
finefocus-5274	40	10	.	.	PUNCT
finefocus-5274	41	1	|	|	ADV
finefocus-5274	41	2	analyzing	analyze	VERB
finefocus-5274	41	3	selected	select	VERB
finefocus-5274	41	4	fda	fda	PROPN
finefocus-5274	41	5	approved	approve	VERB
finefocus-5274	41	6	drugs	drug	NOUN
finefocus-5274	41	7	for	for	ADP
finefocus-5274	41	8	effects	effect	NOUN
finefocus-5274	41	9	on	on	ADP
finefocus-5274	41	10	template	template	NOUN
finefocus-5274	41	11	switch	switch	NOUN
finefocus-5274	41	12	mutagenesis	mutagenesis	NOUN
finefocus-5274	41	13	in	in	ADP
finefocus-5274	41	14	e.	e.	PROPN
finefocus-5274	41	15	coli	coli	PROPN
finefocus-5274	41	16	15	15	NUM
finefocus-5274	41	17	gemcitabine	gemcitabine	NOUN
finefocus-5274	41	18	hydrochloride	hydrochloride	NOUN
finefocus-5274	41	19	(	(	PUNCT
finefocus-5274	41	20	dfdc	dfdc	ADJ
finefocus-5274	41	21	)	)	PUNCT
finefocus-5274	41	22	gemcitabine	gemcitabine	NOUN
finefocus-5274	41	23	hydrochloride	hydrochloride	NOUN
finefocus-5274	41	24	(	(	PUNCT
finefocus-5274	41	25	dfdc	dfdc	PROPN
finefocus-5274	41	26	)	)	PUNCT
finefocus-5274	41	27	is	be	AUX
finefocus-5274	41	28	an	an	DET
finefocus-5274	41	29	fda	fda	PROPN
finefocus-5274	41	30	-	-	PUNCT
finefocus-5274	41	31	approved	approve	VERB
finefocus-5274	41	32	drug	drug	NOUN
finefocus-5274	41	33	used	use	VERB
finefocus-5274	41	34	in	in	ADP
finefocus-5274	41	35	cancer	cancer	NOUN
finefocus-5274	41	36	treatment	treatment	NOUN
finefocus-5274	41	37	.	.	PUNCT
finefocus-5274	42	1	once	once	ADV
finefocus-5274	42	2	inside	inside	ADP
finefocus-5274	42	3	cells	cell	NOUN
finefocus-5274	42	4	,	,	PUNCT
finefocus-5274	42	5	deoxycytidine	deoxycytidine	PROPN
finefocus-5274	42	6	kinase	kinase	PROPN
finefocus-5274	42	7	(	(	PUNCT
finefocus-5274	42	8	dck	dck	PROPN
finefocus-5274	42	9	)	)	PUNCT
finefocus-5274	42	10	phosphorylates	phosphorylate	NOUN
finefocus-5274	42	11	dfdc	dfdc	ADJ
finefocus-5274	42	12	,	,	PUNCT
finefocus-5274	42	13	and	and	CCONJ
finefocus-5274	42	14	subsequent	subsequent	ADJ
finefocus-5274	42	15	phosphorylation	phosphorylation	NOUN
finefocus-5274	42	16	steps	step	NOUN
finefocus-5274	42	17	lead	lead	VERB
finefocus-5274	42	18	to	to	ADP
finefocus-5274	42	19	its	its	PRON
finefocus-5274	42	20	active	active	ADJ
finefocus-5274	42	21	forms	form	NOUN
finefocus-5274	42	22	,	,	PUNCT
finefocus-5274	42	23	dfdcdp	dfdcdp	ADJ
finefocus-5274	42	24	and	and	CCONJ
finefocus-5274	42	25	dfdtp	dfdtp	NOUN
finefocus-5274	42	26	.	.	PUNCT
finefocus-5274	43	1	dfdcdp	dfdcdp	PROPN
finefocus-5274	43	2	inhibits	inhibit	VERB
finefocus-5274	43	3	ribonucleotide	ribonucleotide	ADJ
finefocus-5274	43	4	reductase	reductase	NOUN
finefocus-5274	43	5	,	,	PUNCT
finefocus-5274	43	6	reducing	reduce	VERB
finefocus-5274	43	7	the	the	DET
finefocus-5274	43	8	pool	pool	NOUN
finefocus-5274	43	9	of	of	ADP
finefocus-5274	43	10	deoxynucleotides	deoxynucleotide	NOUN
finefocus-5274	43	11	,	,	PUNCT
finefocus-5274	43	12	mostly	mostly	ADV
finefocus-5274	43	13	dctps	dctps	ADV
finefocus-5274	43	14	,	,	PUNCT
finefocus-5274	43	15	and	and	CCONJ
finefocus-5274	43	16	enhancing	enhance	VERB
finefocus-5274	43	17	the	the	DET
finefocus-5274	43	18	concentration	concentration	NOUN
finefocus-5274	43	19	of	of	ADP
finefocus-5274	43	20	dfdcdp	dfdcdp	PROPN
finefocus-5274	43	21	.	.	PUNCT
finefocus-5274	44	1	this	this	DET
finefocus-5274	44	2	self	self	NOUN
finefocus-5274	44	3	-	-	PUNCT
finefocus-5274	44	4	potentiation	potentiation	NOUN
finefocus-5274	44	5	mechanism	mechanism	NOUN
finefocus-5274	44	6	promotes	promote	VERB
finefocus-5274	44	7	masked	mask	VERB
finefocus-5274	44	8	chain	chain	NOUN
finefocus-5274	44	9	termination	termination	NOUN
finefocus-5274	44	10	that	that	PRON
finefocus-5274	44	11	inhibits	inhibit	VERB
finefocus-5274	44	12	dna	dna	ADJ
finefocus-5274	44	13	synthesis	synthesis	NOUN
finefocus-5274	44	14	and	and	CCONJ
finefocus-5274	44	15	causes	cause	VERB
finefocus-5274	44	16	a	a	DET
finefocus-5274	44	17	fork	fork	NOUN
finefocus-5274	44	18	stalling	stalling	NOUN
finefocus-5274	44	19	event	event	NOUN
finefocus-5274	44	20	(	(	PUNCT
finefocus-5274	44	21	16	16	NUM
finefocus-5274	44	22	)	)	PUNCT
finefocus-5274	44	23	.	.	PUNCT
finefocus-5274	45	1	although	although	SCONJ
finefocus-5274	45	2	there	there	PRON
finefocus-5274	45	3	are	be	VERB
finefocus-5274	45	4	no	no	DET
finefocus-5274	45	5	previous	previous	ADJ
finefocus-5274	45	6	studies	study	NOUN
finefocus-5274	45	7	focusing	focus	VERB
finefocus-5274	45	8	on	on	ADP
finefocus-5274	45	9	gemcitabine	gemcitabine	NOUN
finefocus-5274	45	10	's	's	PART
finefocus-5274	45	11	chain	chain	NOUN
finefocus-5274	45	12	termination	termination	NOUN
finefocus-5274	45	13	effects	effect	NOUN
finefocus-5274	45	14	on	on	ADP
finefocus-5274	45	15	tsm	tsm	NOUN
finefocus-5274	45	16	,	,	PUNCT
finefocus-5274	45	17	studies	study	NOUN
finefocus-5274	45	18	conducted	conduct	VERB
finefocus-5274	45	19	with	with	ADP
finefocus-5274	45	20	the	the	DET
finefocus-5274	45	21	azt	azt	PROPN
finefocus-5274	45	22	chain	chain	NOUN
finefocus-5274	45	23	terminator	terminator	NOUN
finefocus-5274	45	24	drug	drug	PROPN
finefocus-5274	45	25	led	lead	VERB
finefocus-5274	45	26	to	to	ADP
finefocus-5274	45	27	the	the	DET
finefocus-5274	45	28	hypothesis	hypothesis	NOUN
finefocus-5274	45	29	that	that	PRON
finefocus-5274	45	30	gemcitabine	gemcitabine	NOUN
finefocus-5274	45	31	might	might	AUX
finefocus-5274	45	32	similarly	similarly	ADV
finefocus-5274	45	33	be	be	AUX
finefocus-5274	45	34	able	able	ADJ
finefocus-5274	45	35	to	to	PART
finefocus-5274	45	36	enhance	enhance	VERB
finefocus-5274	45	37	tsm	tsm	NOUN
finefocus-5274	45	38	frequency	frequency	NOUN
finefocus-5274	45	39	(	(	PUNCT
finefocus-5274	45	40	11	11	NUM
finefocus-5274	45	41	)	)	PUNCT
finefocus-5274	45	42	.	.	PUNCT
finefocus-5274	46	1	ibuprofen	ibuprofen	PROPN
finefocus-5274	46	2	ibuprofen	ibuprofen	PROPN
finefocus-5274	46	3	is	be	AUX
finefocus-5274	46	4	an	an	DET
finefocus-5274	46	5	fda	fda	PROPN
finefocus-5274	46	6	-	-	PUNCT
finefocus-5274	46	7	approved	approve	VERB
finefocus-5274	46	8	drug	drug	NOUN
finefocus-5274	46	9	that	that	PRON
finefocus-5274	46	10	treats	treat	VERB
finefocus-5274	46	11	inflammation	inflammation	NOUN
finefocus-5274	46	12	and	and	CCONJ
finefocus-5274	46	13	is	be	AUX
finefocus-5274	46	14	used	use	VERB
finefocus-5274	46	15	mostly	mostly	ADV
finefocus-5274	46	16	to	to	PART
finefocus-5274	46	17	treat	treat	VERB
finefocus-5274	46	18	mild	mild	ADJ
finefocus-5274	46	19	forms	form	NOUN
finefocus-5274	46	20	of	of	ADP
finefocus-5274	46	21	pain	pain	NOUN
finefocus-5274	46	22	and	and	CCONJ
finefocus-5274	46	23	reduce	reduce	VERB
finefocus-5274	46	24	fevers	fever	NOUN
finefocus-5274	46	25	.	.	PUNCT
finefocus-5274	47	1	a	a	DET
finefocus-5274	47	2	previous	previous	ADJ
finefocus-5274	47	3	study	study	NOUN
finefocus-5274	47	4	found	find	VERB
finefocus-5274	47	5	that	that	SCONJ
finefocus-5274	47	6	the	the	DET
finefocus-5274	47	7	reactive	reactive	ADJ
finefocus-5274	47	8	oxygen	oxygen	NOUN
finefocus-5274	47	9	species	specie	NOUN
finefocus-5274	47	10	(	(	PUNCT
finefocus-5274	47	11	ros	ros	PROPN
finefocus-5274	47	12	)	)	PUNCT
finefocus-5274	47	13	generated	generate	VERB
finefocus-5274	47	14	by	by	ADP
finefocus-5274	47	15	ibuprofen	ibuprofen	PROPN
finefocus-5274	47	16	caused	cause	VERB
finefocus-5274	47	17	dna	dna	PROPN
finefocus-5274	47	18	strand	strand	NOUN
finefocus-5274	47	19	scission	scission	NOUN
finefocus-5274	47	20	and	and	CCONJ
finefocus-5274	47	21	could	could	AUX
finefocus-5274	47	22	cause	cause	VERB
finefocus-5274	47	23	dna	dna	NOUN
finefocus-5274	47	24	degradation	degradation	NOUN
finefocus-5274	47	25	(	(	PUNCT
finefocus-5274	47	26	17	17	NUM
finefocus-5274	47	27	)	)	PUNCT
finefocus-5274	47	28	.	.	PUNCT
finefocus-5274	48	1	furthermore	furthermore	ADV
finefocus-5274	48	2	,	,	PUNCT
finefocus-5274	48	3	ibuprofen	ibuprofen	PROPN
finefocus-5274	48	4	was	be	AUX
finefocus-5274	48	5	identified	identify	VERB
finefocus-5274	48	6	to	to	PART
finefocus-5274	48	7	have	have	VERB
finefocus-5274	48	8	intercalative	intercalative	ADJ
finefocus-5274	48	9	binding	bind	VERB
finefocus-5274	48	10	with	with	ADP
finefocus-5274	48	11	the	the	DET
finefocus-5274	48	12	dna	dna	PROPN
finefocus-5274	48	13	helix	helix	NOUN
finefocus-5274	48	14	.	.	PUNCT
finefocus-5274	49	1	this	this	PRON
finefocus-5274	49	2	is	be	AUX
finefocus-5274	49	3	where	where	SCONJ
finefocus-5274	49	4	structures	structure	NOUN
finefocus-5274	49	5	resembling	resemble	VERB
finefocus-5274	49	6	base	base	NOUN
finefocus-5274	49	7	pairs	pair	NOUN
finefocus-5274	49	8	will	will	AUX
finefocus-5274	49	9	be	be	AUX
finefocus-5274	49	10	stationed	station	VERB
finefocus-5274	49	11	in	in	ADP
finefocus-5274	49	12	the	the	DET
finefocus-5274	49	13	double	double	ADJ
finefocus-5274	49	14	helix	helix	NOUN
finefocus-5274	49	15	rather	rather	ADV
finefocus-5274	49	16	than	than	ADP
finefocus-5274	49	17	the	the	DET
finefocus-5274	49	18	appropriate	appropriate	ADJ
finefocus-5274	49	19	base	base	NOUN
finefocus-5274	49	20	pairs	pair	NOUN
finefocus-5274	49	21	and	and	CCONJ
finefocus-5274	49	22	thereby	thereby	ADV
finefocus-5274	49	23	distort	distort	VERB
finefocus-5274	49	24	the	the	DET
finefocus-5274	49	25	structure	structure	NOUN
finefocus-5274	49	26	.	.	PUNCT
finefocus-5274	50	1	in	in	ADP
finefocus-5274	50	2	this	this	DET
finefocus-5274	50	3	sense	sense	NOUN
finefocus-5274	50	4	,	,	PUNCT
finefocus-5274	50	5	dna	dna	NOUN
finefocus-5274	50	6	replication	replication	NOUN
finefocus-5274	50	7	is	be	AUX
finefocus-5274	50	8	prevented	prevent	VERB
finefocus-5274	50	9	from	from	ADP
finefocus-5274	50	10	operating	operate	VERB
finefocus-5274	50	11	regularly	regularly	ADV
finefocus-5274	50	12	.	.	PUNCT
finefocus-5274	51	1	we	we	PRON
finefocus-5274	51	2	have	have	AUX
finefocus-5274	51	3	chosen	choose	VERB
finefocus-5274	51	4	to	to	PART
finefocus-5274	51	5	test	test	VERB
finefocus-5274	51	6	ibuprofen	ibuprofen	NOUN
finefocus-5274	51	7	due	due	ADP
finefocus-5274	51	8	to	to	ADP
finefocus-5274	51	9	the	the	DET
finefocus-5274	51	10	potential	potential	ADJ
finefocus-5274	51	11	role	role	NOUN
finefocus-5274	51	12	it	it	PRON
finefocus-5274	51	13	has	have	VERB
finefocus-5274	51	14	in	in	ADP
finefocus-5274	51	15	genetic	genetic	ADJ
finefocus-5274	51	16	instability	instability	NOUN
finefocus-5274	51	17	.	.	PUNCT
finefocus-5274	52	1	dexamethasone	dexamethasone	NOUN
finefocus-5274	52	2	dexamethasone	dexamethasone	NOUN
finefocus-5274	52	3	is	be	AUX
finefocus-5274	52	4	an	an	DET
finefocus-5274	52	5	fda	fda	PROPN
finefocus-5274	52	6	-	-	PUNCT
finefocus-5274	52	7	approved	approve	VERB
finefocus-5274	52	8	hormonal	hormonal	ADJ
finefocus-5274	52	9	corticosteroid	corticosteroid	NOUN
finefocus-5274	52	10	commonly	commonly	ADV
finefocus-5274	52	11	prescribed	prescribe	VERB
finefocus-5274	52	12	to	to	PART
finefocus-5274	52	13	treat	treat	VERB
finefocus-5274	52	14	inflammation	inflammation	NOUN
finefocus-5274	52	15	and	and	CCONJ
finefocus-5274	52	16	swelling	swelling	NOUN
finefocus-5274	52	17	.	.	PUNCT
finefocus-5274	53	1	dexamethasone	dexamethasone	NOUN
finefocus-5274	53	2	is	be	AUX
finefocus-5274	53	3	comprised	comprise	VERB
finefocus-5274	53	4	of	of	ADP
finefocus-5274	53	5	multiple	multiple	ADJ
finefocus-5274	53	6	aromatics	aromatic	NOUN
finefocus-5274	53	7	and	and	CCONJ
finefocus-5274	53	8	hydroxy	hydroxy	PROPN
finefocus-5274	53	9	,	,	PUNCT
finefocus-5274	53	10	methyl	methyl	NOUN
finefocus-5274	53	11	,	,	PUNCT
finefocus-5274	53	12	and	and	CCONJ
finefocus-5274	53	13	oxo	oxo	NOUN
finefocus-5274	53	14	groups	group	NOUN
finefocus-5274	53	15	,	,	PUNCT
finefocus-5274	53	16	making	make	VERB
finefocus-5274	53	17	it	it	PRON
finefocus-5274	53	18	similar	similar	ADJ
finefocus-5274	53	19	in	in	ADP
finefocus-5274	53	20	structure	structure	NOUN
finefocus-5274	53	21	to	to	ADP
finefocus-5274	53	22	other	other	ADJ
finefocus-5274	53	23	corticosteroids	corticosteroid	NOUN
finefocus-5274	53	24	such	such	ADJ
finefocus-5274	53	25	as	as	ADP
finefocus-5274	53	26	hydrocortisone	hydrocortisone	PROPN
finefocus-5274	53	27	and	and	CCONJ
finefocus-5274	53	28	prednisolone	prednisolone	PROPN
finefocus-5274	53	29	.	.	PUNCT
finefocus-5274	54	1	further	further	ADJ
finefocus-5274	54	2	studies	study	NOUN
finefocus-5274	54	3	examining	examine	VERB
finefocus-5274	54	4	the	the	DET
finefocus-5274	54	5	interaction	interaction	NOUN
finefocus-5274	54	6	between	between	ADP
finefocus-5274	54	7	the	the	DET
finefocus-5274	54	8	dexamethasone	dexamethasone	NOUN
finefocus-5274	54	9	-	-	PUNCT
finefocus-5274	54	10	glucocorticoid	glucocorticoid	ADJ
finefocus-5274	54	11	receptor	receptor	NOUN
finefocus-5274	54	12	complex	complex	NOUN
finefocus-5274	54	13	,	,	PUNCT
finefocus-5274	54	14	and	and	CCONJ
finefocus-5274	54	15	dna	dna	PROPN
finefocus-5274	54	16	have	have	AUX
finefocus-5274	54	17	suggested	suggest	VERB
finefocus-5274	54	18	the	the	DET
finefocus-5274	54	19	potential	potential	NOUN
finefocus-5274	54	20	for	for	SCONJ
finefocus-5274	54	21	dexamethasone	dexamethasone	NOUN
finefocus-5274	54	22	to	to	PART
finefocus-5274	54	23	behave	behave	VERB
finefocus-5274	54	24	as	as	ADP
finefocus-5274	54	25	an	an	DET
finefocus-5274	54	26	intercalating	intercalate	VERB
finefocus-5274	54	27	agent	agent	NOUN
finefocus-5274	54	28	(	(	PUNCT
finefocus-5274	54	29	18	18	NUM
finefocus-5274	54	30	)	)	PUNCT
finefocus-5274	54	31	,	,	PUNCT
finefocus-5274	54	32	giving	give	VERB
finefocus-5274	54	33	it	it	PRON
finefocus-5274	54	34	the	the	DET
finefocus-5274	54	35	potential	potential	NOUN
finefocus-5274	54	36	to	to	PART
finefocus-5274	54	37	cause	cause	VERB
finefocus-5274	54	38	template	template	NOUN
finefocus-5274	54	39	switch	switch	NOUN
finefocus-5274	54	40	mutations	mutation	NOUN
finefocus-5274	54	41	.	.	PUNCT
finefocus-5274	55	1	doxorubicin	doxorubicin	PROPN
finefocus-5274	55	2	hydrochloride	hydrochloride	PROPN
finefocus-5274	55	3	doxorubicin	doxorubicin	PROPN
finefocus-5274	55	4	hydrochloride	hydrochloride	NOUN
finefocus-5274	55	5	(	(	PUNCT
finefocus-5274	55	6	doxo	doxo	PROPN
finefocus-5274	55	7	)	)	PUNCT
finefocus-5274	55	8	is	be	AUX
finefocus-5274	55	9	a	a	DET
finefocus-5274	55	10	chemical	chemical	NOUN
finefocus-5274	55	11	capable	capable	ADJ
finefocus-5274	55	12	of	of	ADP
finefocus-5274	55	13	inhibiting	inhibit	VERB
finefocus-5274	55	14	topoisomerase	topoisomerase	ADJ
finefocus-5274	55	15	ii	ii	NOUN
finefocus-5274	55	16	(	(	PUNCT
finefocus-5274	55	17	19	19	NUM
finefocus-5274	55	18	)	)	PUNCT
finefocus-5274	55	19	,	,	PUNCT
finefocus-5274	55	20	generating	generate	VERB
finefocus-5274	55	21	reactive	reactive	ADJ
finefocus-5274	55	22	oxygen	oxygen	NOUN
finefocus-5274	55	23	species	specie	NOUN
finefocus-5274	55	24	(	(	PUNCT
finefocus-5274	55	25	20	20	NUM
finefocus-5274	55	26	)	)	PUNCT
finefocus-5274	55	27	,	,	PUNCT
finefocus-5274	55	28	and	and	CCONJ
finefocus-5274	55	29	intercalating	intercalate	VERB
finefocus-5274	55	30	dna	dna	PROPN
finefocus-5274	55	31	(	(	PUNCT
finefocus-5274	55	32	21	21	NUM
finefocus-5274	55	33	)	)	PUNCT
finefocus-5274	55	34	.	.	PUNCT
finefocus-5274	56	1	here	here	ADV
finefocus-5274	56	2	we	we	PRON
finefocus-5274	56	3	evaluate	evaluate	VERB
finefocus-5274	56	4	the	the	DET
finefocus-5274	56	5	potential	potential	ADJ
finefocus-5274	56	6	role	role	NOUN
finefocus-5274	56	7	of	of	ADP
finefocus-5274	56	8	doxo	doxo	NOUN
finefocus-5274	56	9	in	in	ADP
finefocus-5274	56	10	tsm	tsm	NOUN
finefocus-5274	56	11	due	due	ADP
finefocus-5274	56	12	to	to	ADP
finefocus-5274	56	13	inhibiting	inhibit	VERB
finefocus-5274	56	14	topoisomerases	topoisomerase	NOUN
finefocus-5274	56	15	and	and	CCONJ
finefocus-5274	56	16	doxo	doxo	VERB
finefocus-5274	56	17	mediated	mediate	VERB
finefocus-5274	56	18	dna	dna	ADJ
finefocus-5274	56	19	-	-	PUNCT
finefocus-5274	56	20	protein	protein	NOUN
finefocus-5274	56	21	crosslinks	crosslink	NOUN
finefocus-5274	56	22	,	,	PUNCT
finefocus-5274	56	23	similarly	similarly	ADV
finefocus-5274	56	24	to	to	ADP
finefocus-5274	56	25	how	how	SCONJ
finefocus-5274	56	26	5	5	NUM
finefocus-5274	56	27	-	-	PUNCT
finefocus-5274	56	28	azac	azac	NOUN
finefocus-5274	56	29	and	and	CCONJ
finefocus-5274	56	30	ciprofloxacin	ciprofloxacin	PROPN
finefocus-5274	56	31	have	have	AUX
finefocus-5274	56	32	been	be	AUX
finefocus-5274	56	33	shown	show	VERB
finefocus-5274	56	34	to	to	PART
finefocus-5274	56	35	promote	promote	VERB
finefocus-5274	56	36	tsm	tsm	NOUN
finefocus-5274	56	37	by	by	ADP
finefocus-5274	56	38	stalling	stall	VERB
finefocus-5274	56	39	replication	replication	NOUN
finefocus-5274	56	40	(	(	PUNCT
finefocus-5274	56	41	10	10	NUM
finefocus-5274	56	42	)	)	PUNCT
finefocus-5274	56	43	implicating	implicate	VERB
finefocus-5274	56	44	the	the	DET
finefocus-5274	56	45	dcm	dcm	PROPN
finefocus-5274	56	46	-	-	ADJ
finefocus-5274	56	47	dna	dna	PROPN
finefocus-5274	56	48	covalent	covalent	NOUN
finefocus-5274	56	49	complex	complex	NOUN
finefocus-5274	56	50	trapped	trap	VERB
finefocus-5274	56	51	by	by	ADP
finefocus-5274	56	52	5	5	NUM
finefocus-5274	56	53	-	-	PUNCT
finefocus-5274	56	54	azac	azac	NOUN
finefocus-5274	56	55	as	as	ADP
finefocus-5274	56	56	the	the	DET
finefocus-5274	56	57	initiator	initiator	NOUN
finefocus-5274	56	58	for	for	ADP
finefocus-5274	56	59	mutagenesis	mutagenesis	NOUN
finefocus-5274	56	60	.	.	PUNCT
finefocus-5274	57	1	the	the	DET
finefocus-5274	57	2	leading	lead	VERB
finefocus-5274	57	3	strand	strand	NOUN
finefocus-5274	57	4	of	of	ADP
finefocus-5274	57	5	replication	replication	NOUN
finefocus-5274	57	6	is	be	AUX
finefocus-5274	57	7	more	more	ADV
finefocus-5274	57	8	mutable	mutable	ADJ
finefocus-5274	57	9	than	than	ADP
finefocus-5274	57	10	the	the	DET
finefocus-5274	57	11	lagging	lag	VERB
finefocus-5274	57	12	strand	strand	NOUN
finefocus-5274	57	13	,	,	PUNCT
finefocus-5274	57	14	which	which	PRON
finefocus-5274	57	15	can	can	AUX
finefocus-5274	57	16	be	be	AUX
finefocus-5274	57	17	explained	explain	VERB
finefocus-5274	57	18	by	by	ADP
finefocus-5274	57	19	blocks	block	NOUN
finefocus-5274	57	20	to	to	ADP
finefocus-5274	57	21	the	the	DET
finefocus-5274	57	22	replicative	replicative	ADJ
finefocus-5274	57	23	helicase	helicase	NOUN
finefocus-5274	57	24	and/or	and/or	CCONJ
finefocus-5274	57	25	fork	fork	VERB
finefocus-5274	57	26	regression	regression	NOUN
finefocus-5274	57	27	.	.	PUNCT
finefocus-5274	58	1	we	we	PRON
finefocus-5274	58	2	find	find	VERB
finefocus-5274	58	3	that	that	SCONJ
finefocus-5274	58	4	template	template	NOUN
finefocus-5274	58	5	-	-	PUNCT
finefocus-5274	58	6	switch	switch	NOUN
finefocus-5274	58	7	mutagenesis	mutagenesis	NOUN
finefocus-5274	58	8	induced	induce	VERB
finefocus-5274	58	9	by	by	ADP
finefocus-5274	58	10	5	5	NUM
finefocus-5274	58	11	-	-	PUNCT
finefocus-5274	58	12	azac	azac	NOUN
finefocus-5274	58	13	does	do	AUX
finefocus-5274	58	14	not	not	PART
finefocus-5274	58	15	require	require	VERB
finefocus-5274	58	16	double	double	ADJ
finefocus-5274	58	17	strand	strand	NOUN
finefocus-5274	58	18	break	break	NOUN
finefocus-5274	58	19	repair	repair	NOUN
finefocus-5274	58	20	via	via	ADP
finefocus-5274	58	21	recabcd	recabcd	NOUN
finefocus-5274	58	22	;	;	PUNCT
finefocus-5274	58	23	the	the	DET
finefocus-5274	58	24	ability	ability	NOUN
finefocus-5274	58	25	to	to	PART
finefocus-5274	58	26	induce	induce	VERB
finefocus-5274	58	27	the	the	DET
finefocus-5274	58	28	sos	sos	PROPN
finefocus-5274	58	29	response	response	NOUN
finefocus-5274	58	30	is	be	AUX
finefocus-5274	58	31	anti	anti	ADJ
finefocus-5274	58	32	-	-	ADJ
finefocus-5274	58	33	mutagenic	mutagenic	ADJ
finefocus-5274	58	34	.	.	PUNCT
finefocus-5274	59	1	mutants	mutant	NOUN
finefocus-5274	59	2	in	in	ADP
finefocus-5274	59	3	recb	recb	NOUN
finefocus-5274	59	4	,	,	PUNCT
finefocus-5274	59	5	but	but	CCONJ
finefocus-5274	59	6	not	not	PART
finefocus-5274	59	7	reca	reca	NOUN
finefocus-5274	59	8	,	,	PUNCT
finefocus-5274	59	9	exhibit	exhibit	VERB
finefocus-5274	59	10	high	high	ADJ
finefocus-5274	59	11	constitutive	constitutive	ADJ
finefocus-5274	59	12	rates	rate	NOUN
finefocus-5274	59	13	of	of	ADP
finefocus-5274	59	14	template	template	NOUN
finefocus-5274	59	15	-	-	PUNCT
finefocus-5274	59	16	switching	switching	NOUN
finefocus-5274	59	17	,	,	PUNCT
finefocus-5274	59	18	and	and	CCONJ
finefocus-5274	59	19	we	we	PRON
finefocus-5274	59	20	suggest	suggest	VERB
finefocus-5274	59	21	that	that	SCONJ
finefocus-5274	59	22	recbcd	recbcd	NOUN
finefocus-5274	59	23	-	-	PUNCT
finefocus-5274	59	24	mediated	mediate	VERB
finefocus-5274	59	25	dna	dna	NOUN
finefocus-5274	59	26	degradation	degradation	NOUN
finefocus-5274	59	27	prevents	prevent	VERB
finefocus-5274	59	28	template	template	NOUN
finefocus-5274	59	29	-	-	PUNCT
finefocus-5274	59	30	switching	switching	NOUN
finefocus-5274	59	31	associated	associate	VERB
finefocus-5274	59	32	with	with	ADP
finefocus-5274	59	33	fork	fork	NOUN
finefocus-5274	59	34	regression	regression	NOUN
finefocus-5274	59	35	.	.	PUNCT
finefocus-5274	60	1	a	a	DET
finefocus-5274	60	2	mutation	mutation	NOUN
finefocus-5274	60	3	in	in	ADP
finefocus-5274	60	4	the	the	DET
finefocus-5274	60	5	dnab	dnab	NOUN
finefocus-5274	60	6	fork	fork	PROPN
finefocus-5274	60	7	helicase	helicase	NOUN
finefocus-5274	60	8	also	also	ADV
finefocus-5274	60	9	promotes	promote	VERB
finefocus-5274	60	10	high	high	ADJ
finefocus-5274	60	11	levels	level	NOUN
finefocus-5274	60	12	of	of	ADP
finefocus-5274	60	13	template	template	NOUN
finefocus-5274	60	14	-	-	PUNCT
finefocus-5274	60	15	switching	switching	NOUN
finefocus-5274	60	16	.	.	PUNCT
finefocus-5274	61	1	we	we	PRON
finefocus-5274	61	2	also	also	ADV
finefocus-5274	61	3	find	find	VERB
finefocus-5274	61	4	that	that	SCONJ
finefocus-5274	61	5	other	other	ADJ
finefocus-5274	61	6	dpc	dpc	NOUN
finefocus-5274	61	7	-	-	PUNCT
finefocus-5274	61	8	inducers	inducer	NOUN
finefocus-5274	61	9	,	,	PUNCT
finefocus-5274	61	10	formaldehyde	formaldehyde	NOUN
finefocus-5274	61	11	(	(	PUNCT
finefocus-5274	61	12	a	a	DET
finefocus-5274	61	13	non	non	ADJ
finefocus-5274	61	14	-	-	ADJ
finefocus-5274	61	15	specific	specific	ADJ
finefocus-5274	61	16	crosslinker	crosslinker	NOUN
finefocus-5274	61	17	.	.	PUNCT
finefocus-5274	62	1	irinotecan	irinotecan	PROPN
finefocus-5274	62	2	hydrochloride	hydrochloride	NOUN
finefocus-5274	62	3	(	(	PUNCT
finefocus-5274	62	4	cpt-11	cpt-11	NOUN
finefocus-5274	62	5	)	)	PUNCT
finefocus-5274	62	6	irinotecan	irinotecan	ADJ
finefocus-5274	62	7	hydrochloride	hydrochloride	NOUN
finefocus-5274	62	8	(	(	PUNCT
finefocus-5274	62	9	cpt-11	cpt-11	NOUN
finefocus-5274	62	10	)	)	PUNCT
finefocus-5274	62	11	,	,	PUNCT
finefocus-5274	62	12	derived	derive	VERB
finefocus-5274	62	13	from	from	ADP
finefocus-5274	62	14	camptothecin	camptothecin	PROPN
finefocus-5274	62	15	,	,	PUNCT
finefocus-5274	62	16	is	be	AUX
finefocus-5274	62	17	a	a	DET
finefocus-5274	62	18	chemotherapeutic	chemotherapeutic	ADJ
finefocus-5274	62	19	drug	drug	NOUN
finefocus-5274	62	20	that	that	PRON
finefocus-5274	62	21	inhibits	inhibit	VERB
finefocus-5274	62	22	topoisomerase	topoisomerase	NOUN
finefocus-5274	62	23	i	i	PRON
finefocus-5274	62	24	(	(	PUNCT
finefocus-5274	62	25	22	22	NUM
finefocus-5274	62	26	,	,	PUNCT
finefocus-5274	62	27	23	23	NUM
finefocus-5274	62	28	)	)	PUNCT
finefocus-5274	62	29	.	.	PUNCT
finefocus-5274	63	1	the	the	DET
finefocus-5274	63	2	inhibition	inhibition	NOUN
finefocus-5274	63	3	of	of	ADP
finefocus-5274	63	4	topoisomerase	topoisomerase	NOUN
finefocus-5274	63	5	i	i	PRON
finefocus-5274	63	6	by	by	ADP
finefocus-5274	63	7	cpt-11	cpt-11	PROPN
finefocus-5274	63	8	results	result	NOUN
finefocus-5274	63	9	in	in	ADP
finefocus-5274	63	10	the	the	DET
finefocus-5274	63	11	formation	formation	NOUN
finefocus-5274	63	12	of	of	ADP
finefocus-5274	63	13	highly	highly	ADV
finefocus-5274	63	14	cytotoxic	cytotoxic	ADJ
finefocus-5274	63	15	topoisomerase	topoisomerase	NOUN
finefocus-5274	63	16	i	i	NOUN
finefocus-5274	63	17	-	-	PUNCT
finefocus-5274	63	18	dna	dna	PROPN
finefocus-5274	63	19	cleavage	cleavage	NOUN
finefocus-5274	63	20	complexes	complex	NOUN
finefocus-5274	63	21	,	,	PUNCT
finefocus-5274	63	22	importantly	importantly	ADV
finefocus-5274	63	23	triggering	trigger	VERB
finefocus-5274	63	24	various	various	ADJ
finefocus-5274	63	25	cellular	cellular	ADJ
finefocus-5274	63	26	responses	response	NOUN
finefocus-5274	63	27	,	,	PUNCT
finefocus-5274	63	28	including	include	VERB
finefocus-5274	63	29	proteinlinked	proteinlinke	VERB
finefocus-5274	63	30	dna	dna	PROPN
finefocus-5274	63	31	breaks	break	VERB
finefocus-5274	63	32	23	23	NUM
finefocus-5274	63	33	and	and	CCONJ
finefocus-5274	63	34	replication	replication	NOUN
finefocus-5274	63	35	fork	fork	NOUN
finefocus-5274	63	36	arrest24	arrest24	NOUN
finefocus-5274	63	37	.	.	PUNCT
finefocus-5274	64	1	due	due	ADP
finefocus-5274	64	2	to	to	ADP
finefocus-5274	64	3	the	the	DET
finefocus-5274	64	4	similarities	similarity	NOUN
finefocus-5274	64	5	of	of	ADP
finefocus-5274	64	6	properties	property	NOUN
finefocus-5274	64	7	with	with	ADP
finefocus-5274	64	8	other	other	ADJ
finefocus-5274	64	9	tsm	tsm	NOUN
finefocus-5274	64	10	causing	cause	VERB
finefocus-5274	64	11	drugs	drug	NOUN
finefocus-5274	64	12	,	,	PUNCT
finefocus-5274	64	13	we	we	PRON
finefocus-5274	64	14	have	have	AUX
finefocus-5274	64	15	included	include	VERB
finefocus-5274	64	16	the	the	DET
finefocus-5274	64	17	evaluation	evaluation	NOUN
finefocus-5274	64	18	of	of	ADP
finefocus-5274	64	19	cpt-11	cpt-11	PROPN
finefocus-5274	64	20	.	.	PROPN
finefocus-5274	64	21	fine	fine	ADJ
finefocus-5274	64	22	focus	focus	NOUN
finefocus-5274	64	23	|	|	ADV
finefocus-5274	64	24	volume	volume	VERB
finefocus-5274	64	25	1116	1116	NUM
finefocus-5274	64	26	figure	figure	NOUN
finefocus-5274	64	27	2	2	NUM
finefocus-5274	64	28	.	.	PUNCT
finefocus-5274	64	29	mutational	mutational	ADJ
finefocus-5274	64	30	assay	assay	NOUN
finefocus-5274	64	31	methods	method	NOUN
finefocus-5274	64	32	a.	a.	PROPN
finefocus-5274	64	33	single	single	ADJ
finefocus-5274	64	34	colonies	colony	NOUN
finefocus-5274	64	35	were	be	AUX
finefocus-5274	64	36	selected	select	VERB
finefocus-5274	64	37	,	,	PUNCT
finefocus-5274	64	38	inoculated	inoculate	VERB
finefocus-5274	64	39	,	,	PUNCT
finefocus-5274	64	40	and	and	CCONJ
finefocus-5274	64	41	cultured	cultured	ADJ
finefocus-5274	64	42	overnight	overnight	ADV
finefocus-5274	64	43	.	.	PUNCT
finefocus-5274	65	1	b.	b.	PROPN
finefocus-5274	65	2	cultures	culture	NOUN
finefocus-5274	65	3	were	be	AUX
finefocus-5274	65	4	diluted	dilute	VERB
finefocus-5274	65	5	and	and	CCONJ
finefocus-5274	65	6	incubated	incubate	VERB
finefocus-5274	65	7	for	for	ADP
finefocus-5274	65	8	2	2	NUM
finefocus-5274	65	9	hours	hour	NOUN
finefocus-5274	65	10	before	before	ADP
finefocus-5274	65	11	pelleting	pellete	VERB
finefocus-5274	65	12	via	via	ADP
finefocus-5274	65	13	centrifugation	centrifugation	NOUN
finefocus-5274	65	14	.	.	PUNCT
finefocus-5274	66	1	c.	c.	NOUN
finefocus-5274	66	2	cultures	culture	NOUN
finefocus-5274	66	3	were	be	AUX
finefocus-5274	66	4	divided	divide	VERB
finefocus-5274	66	5	into	into	ADP
finefocus-5274	66	6	treated	treat	VERB
finefocus-5274	66	7	and	and	CCONJ
finefocus-5274	66	8	control	control	VERB
finefocus-5274	66	9	tubes	tube	NOUN
finefocus-5274	66	10	before	before	ADP
finefocus-5274	66	11	adding	add	VERB
finefocus-5274	66	12	drug	drug	NOUN
finefocus-5274	66	13	or	or	CCONJ
finefocus-5274	66	14	control	control	NOUN
finefocus-5274	66	15	at	at	ADP
finefocus-5274	66	16	the	the	DET
finefocus-5274	66	17	provided	provide	VERB
finefocus-5274	66	18	concentrations	concentration	NOUN
finefocus-5274	66	19	.	.	PUNCT
finefocus-5274	67	1	cultures	culture	NOUN
finefocus-5274	67	2	were	be	AUX
finefocus-5274	67	3	then	then	ADV
finefocus-5274	67	4	incubated	incubate	VERB
finefocus-5274	67	5	for	for	ADP
finefocus-5274	67	6	2	2	NUM
finefocus-5274	67	7	hours	hour	NOUN
finefocus-5274	67	8	.	.	PUNCT
finefocus-5274	68	1	d.	d.	PROPN
finefocus-5274	68	2	cultures	culture	NOUN
finefocus-5274	68	3	were	be	AUX
finefocus-5274	68	4	pelleted	pellete	VERB
finefocus-5274	68	5	via	via	ADP
finefocus-5274	68	6	centrifugation	centrifugation	NOUN
finefocus-5274	68	7	and	and	CCONJ
finefocus-5274	68	8	the	the	DET
finefocus-5274	68	9	cell	cell	NOUN
finefocus-5274	68	10	pellets	pellet	NOUN
finefocus-5274	68	11	were	be	AUX
finefocus-5274	68	12	washed	wash	VERB
finefocus-5274	68	13	before	before	ADP
finefocus-5274	68	14	resuspending	resuspend	VERB
finefocus-5274	68	15	the	the	DET
finefocus-5274	68	16	cells	cell	NOUN
finefocus-5274	68	17	and	and	CCONJ
finefocus-5274	68	18	performing	perform	VERB
finefocus-5274	68	19	serial	serial	ADJ
finefocus-5274	68	20	dilutions	dilution	NOUN
finefocus-5274	68	21	.	.	PUNCT
finefocus-5274	69	1	dilutions	dilution	NOUN
finefocus-5274	69	2	were	be	AUX
finefocus-5274	69	3	plated	plate	VERB
finefocus-5274	69	4	on	on	ADP
finefocus-5274	69	5	lb	lb	PRON
finefocus-5274	69	6	and	and	CCONJ
finefocus-5274	69	7	minimum	minimum	ADJ
finefocus-5274	69	8	lactose	lactose	NOUN
finefocus-5274	69	9	plates	plate	NOUN
finefocus-5274	69	10	and	and	CCONJ
finefocus-5274	69	11	incubated	incubate	VERB
finefocus-5274	69	12	overnight	overnight	ADV
finefocus-5274	69	13	.	.	PUNCT
finefocus-5274	70	1	e.	e.	PROPN
finefocus-5274	70	2	total	total	PROPN
finefocus-5274	70	3	colony	colony	NOUN
finefocus-5274	70	4	forming	form	VERB
finefocus-5274	70	5	units	unit	NOUN
finefocus-5274	70	6	(	(	PUNCT
finefocus-5274	70	7	cfus)/ml	cfus)/ml	NUM
finefocus-5274	70	8	were	be	AUX
finefocus-5274	70	9	determined	determine	VERB
finefocus-5274	70	10	and	and	CCONJ
finefocus-5274	70	11	percentage	percentage	NOUN
finefocus-5274	70	12	of	of	ADP
finefocus-5274	70	13	reverting	revert	VERB
finefocus-5274	70	14	cfus	cfus	NOUN
finefocus-5274	70	15	were	be	AUX
finefocus-5274	70	16	calculated	calculate	VERB
finefocus-5274	70	17	.	.	PUNCT
finefocus-5274	71	1	(	(	PUNCT
finefocus-5274	71	2	created	create	VERB
finefocus-5274	71	3	in	in	ADP
finefocus-5274	71	4	https://biorender.com	https://biorender.com	X
finefocus-5274	71	5	)	)	PUNCT
finefocus-5274	71	6	https://biorender.com	https://biorender.com	X
finefocus-5274	71	7	swain	swain	PROPN
finefocus-5274	71	8	et	et	PROPN
finefocus-5274	71	9	al	al	PROPN
finefocus-5274	71	10	.	.	PUNCT
finefocus-5274	72	1	|	|	ADV
finefocus-5274	72	2	analyzing	analyze	VERB
finefocus-5274	72	3	selected	select	VERB
finefocus-5274	72	4	fda	fda	PROPN
finefocus-5274	72	5	approved	approve	VERB
finefocus-5274	72	6	drugs	drug	NOUN
finefocus-5274	72	7	for	for	ADP
finefocus-5274	72	8	effects	effect	NOUN
finefocus-5274	72	9	on	on	ADP
finefocus-5274	72	10	template	template	NOUN
finefocus-5274	72	11	switch	switch	NOUN
finefocus-5274	72	12	mutagenesis	mutagenesis	NOUN
finefocus-5274	72	13	in	in	ADP
finefocus-5274	72	14	e.	e.	PROPN
finefocus-5274	72	15	coli	coli	PROPN
finefocus-5274	72	16	17	17	NUM
finefocus-5274	72	17	methods	method	NOUN
finefocus-5274	72	18	bacterial	bacterial	ADJ
finefocus-5274	72	19	strains	strain	NOUN
finefocus-5274	72	20	,	,	PUNCT
finefocus-5274	72	21	growth	growth	NOUN
finefocus-5274	72	22	conditions	condition	NOUN
finefocus-5274	72	23	,	,	PUNCT
finefocus-5274	72	24	and	and	CCONJ
finefocus-5274	72	25	media	media	VERB
finefocus-5274	72	26	a	a	DET
finefocus-5274	72	27	lacz	lacz	NOUN
finefocus-5274	72	28	mutational	mutational	ADJ
finefocus-5274	72	29	reporter	reporter	NOUN
finefocus-5274	72	30	strain	strain	NOUN
finefocus-5274	72	31	of	of	ADP
finefocus-5274	72	32	escherichia	escherichia	NOUN
finefocus-5274	72	33	coli	coli	NOUN
finefocus-5274	72	34	,	,	PUNCT
finefocus-5274	72	35	qp5	qp5	NOUN
finefocus-5274	72	36	,	,	PUNCT
finefocus-5274	72	37	that	that	PRON
finefocus-5274	72	38	reverts	revert	VERB
finefocus-5274	72	39	to	to	ADP
finefocus-5274	72	40	lac+	lac+	PROPN
finefocus-5274	72	41	when	when	SCONJ
finefocus-5274	72	42	a	a	DET
finefocus-5274	72	43	4	4	NUM
finefocus-5274	72	44	base	base	NOUN
finefocus-5274	72	45	pair	pair	NOUN
finefocus-5274	72	46	deletion	deletion	NOUN
finefocus-5274	72	47	occurs	occur	VERB
finefocus-5274	72	48	due	due	ADJ
finefocus-5274	72	49	to	to	ADP
finefocus-5274	72	50	a	a	DET
finefocus-5274	72	51	template	template	NOUN
finefocus-5274	72	52	switch	switch	NOUN
finefocus-5274	72	53	mutation	mutation	NOUN
finefocus-5274	72	54	was	be	AUX
finefocus-5274	72	55	acquired	acquire	VERB
finefocus-5274	72	56	from	from	ADP
finefocus-5274	72	57	dr	dr	PROPN
finefocus-5274	72	58	.	.	PROPN
finefocus-5274	72	59	susan	susan	PROPN
finefocus-5274	72	60	t.	t.	PROPN
finefocus-5274	72	61	lovett	lovett	PROPN
finefocus-5274	72	62	(	(	PUNCT
finefocus-5274	72	63	used	use	VERB
finefocus-5274	72	64	in	in	ADP
finefocus-5274	72	65	laranjo	laranjo	PROPN
finefocus-5274	72	66	et	et	PROPN
finefocus-5274	72	67	al	al	PROPN
finefocus-5274	72	68	.	.	PROPN
finefocus-5274	72	69	2017	2017	NUM
finefocus-5274	72	70	)	)	PUNCT
finefocus-5274	73	1	25	25	NUM
finefocus-5274	73	2	.	.	PUNCT
finefocus-5274	73	3	standard	standard	ADJ
finefocus-5274	73	4	growth	growth	NOUN
finefocus-5274	73	5	medium	medium	NOUN
finefocus-5274	73	6	was	be	AUX
finefocus-5274	73	7	luria	luria	ADJ
finefocus-5274	73	8	broth	broth	NOUN
finefocus-5274	73	9	(	(	PUNCT
finefocus-5274	73	10	lb	lb	NOUN
finefocus-5274	73	11	)	)	PUNCT
finefocus-5274	73	12	medium	medium	NOUN
finefocus-5274	73	13	,	,	PUNCT
finefocus-5274	73	14	comprised	comprise	VERB
finefocus-5274	73	15	of	of	ADP
finefocus-5274	73	16	1	1	NUM
finefocus-5274	73	17	%	%	NOUN
finefocus-5274	73	18	bacto	bacto	NOUN
finefocus-5274	73	19	-	-	PUNCT
finefocus-5274	73	20	tryptone	tryptone	ADJ
finefocus-5274	73	21	,	,	PUNCT
finefocus-5274	73	22	0.5	0.5	NUM
finefocus-5274	73	23	%	%	NOUN
finefocus-5274	73	24	yeast	yeast	NOUN
finefocus-5274	73	25	extract	extract	NOUN
finefocus-5274	73	26	,	,	PUNCT
finefocus-5274	73	27	and	and	CCONJ
finefocus-5274	73	28	0.5	0.5	NUM
finefocus-5274	73	29	%	%	NOUN
finefocus-5274	73	30	sodium	sodium	NOUN
finefocus-5274	73	31	chloride	chloride	NOUN
finefocus-5274	73	32	(	(	PUNCT
finefocus-5274	73	33	fisher	fisher	PROPN
finefocus-5274	73	34	scientific	scientific	PROPN
finefocus-5274	73	35	,	,	PUNCT
finefocus-5274	73	36	waltham	waltham	PROPN
finefocus-5274	73	37	,	,	PUNCT
finefocus-5274	73	38	ma	ma	PROPN
finefocus-5274	73	39	,	,	PUNCT
finefocus-5274	73	40	usa	usa	PROPN
finefocus-5274	73	41	)	)	PUNCT
finefocus-5274	73	42	and	and	CCONJ
finefocus-5274	73	43	minimum	minimum	NOUN
finefocus-5274	73	44	lactose	lactose	NOUN
finefocus-5274	73	45	solid	solid	ADJ
finefocus-5274	73	46	medium	medium	NOUN
finefocus-5274	73	47	,	,	PUNCT
finefocus-5274	73	48	comprised	comprise	VERB
finefocus-5274	73	49	of	of	ADP
finefocus-5274	73	50	1x	1x	PROPN
finefocus-5274	73	51	m9	m9	PROPN
finefocus-5274	73	52	salts	salt	NOUN
finefocus-5274	73	53	,	,	PUNCT
finefocus-5274	73	54	0.2	0.2	NUM
finefocus-5274	73	55	%	%	NOUN
finefocus-5274	73	56	lactose	lactose	NOUN
finefocus-5274	73	57	,	,	PUNCT
finefocus-5274	73	58	1	1	NUM
finefocus-5274	73	59	mm	mm	NOUN
finefocus-5274	73	60	magnesium	magnesium	NOUN
finefocus-5274	73	61	sulfate	sulfate	NOUN
finefocus-5274	73	62	,	,	PUNCT
finefocus-5274	73	63	and	and	CCONJ
finefocus-5274	73	64	0.1	0.1	NUM
finefocus-5274	73	65	mm	mm	NOUN
finefocus-5274	73	66	calcium	calcium	NOUN
finefocus-5274	73	67	chloride	chloride	NOUN
finefocus-5274	73	68	(	(	PUNCT
finefocus-5274	73	69	alpha	alpha	NOUN
finefocus-5274	73	70	teknova	teknova	PROPN
finefocus-5274	73	71	,	,	PUNCT
finefocus-5274	73	72	hollister	hollister	PROPN
finefocus-5274	73	73	,	,	PUNCT
finefocus-5274	73	74	ca	ca	PROPN
finefocus-5274	73	75	,	,	PUNCT
finefocus-5274	73	76	usa	usa	PROPN
finefocus-5274	73	77	)	)	PUNCT
finefocus-5274	73	78	.	.	PUNCT
finefocus-5274	74	1	plates	plate	NOUN
finefocus-5274	74	2	were	be	AUX
finefocus-5274	74	3	also	also	ADV
finefocus-5274	74	4	comprised	comprise	VERB
finefocus-5274	74	5	of	of	ADP
finefocus-5274	74	6	1.5	1.5	NUM
finefocus-5274	74	7	%	%	NOUN
finefocus-5274	74	8	bacto	bacto	NOUN
finefocus-5274	74	9	-	-	PUNCT
finefocus-5274	74	10	agar	agar	NOUN
finefocus-5274	74	11	.	.	PUNCT
finefocus-5274	75	1	mutational	mutational	ADJ
finefocus-5274	75	2	assay	assay	ADJ
finefocus-5274	75	3	single	single	ADJ
finefocus-5274	75	4	colonies	colony	NOUN
finefocus-5274	75	5	were	be	AUX
finefocus-5274	75	6	inoculated	inoculate	VERB
finefocus-5274	75	7	and	and	CCONJ
finefocus-5274	75	8	cultured	cultured	ADJ
finefocus-5274	75	9	in	in	ADP
finefocus-5274	75	10	1.5	1.5	NUM
finefocus-5274	75	11	ml	ml	NOUN
finefocus-5274	75	12	of	of	ADP
finefocus-5274	75	13	luria	luria	ADJ
finefocus-5274	75	14	broth	broth	NOUN
finefocus-5274	75	15	(	(	PUNCT
finefocus-5274	75	16	lb	lb	NOUN
finefocus-5274	75	17	)	)	PUNCT
finefocus-5274	75	18	medium	medium	NOUN
finefocus-5274	75	19	and	and	CCONJ
finefocus-5274	75	20	grown	grow	VERB
finefocus-5274	75	21	overnight	overnight	ADV
finefocus-5274	75	22	at	at	ADP
finefocus-5274	75	23	37	37	NUM
finefocus-5274	75	24	°	°	ADP
finefocus-5274	75	25	c	c	NOUN
finefocus-5274	75	26	with	with	ADP
finefocus-5274	75	27	aeration	aeration	NOUN
finefocus-5274	75	28	(	(	PUNCT
finefocus-5274	75	29	figure	figure	NOUN
finefocus-5274	75	30	2a	2a	NUM
finefocus-5274	75	31	)	)	PUNCT
finefocus-5274	75	32	.	.	PUNCT
finefocus-5274	76	1	the	the	DET
finefocus-5274	76	2	culture	culture	NOUN
finefocus-5274	76	3	underwent	undergo	VERB
finefocus-5274	76	4	a	a	DET
finefocus-5274	76	5	1:100	1:100	NUM
finefocus-5274	76	6	dilution	dilution	NOUN
finefocus-5274	76	7	in	in	ADP
finefocus-5274	76	8	fresh	fresh	ADJ
finefocus-5274	76	9	1.5	1.5	NUM
finefocus-5274	76	10	ml	ml	NOUN
finefocus-5274	76	11	lb	lb	PRON
finefocus-5274	76	12	medium	medium	NOUN
finefocus-5274	76	13	,	,	PUNCT
finefocus-5274	76	14	followed	follow	VERB
finefocus-5274	76	15	by	by	ADP
finefocus-5274	76	16	a	a	DET
finefocus-5274	76	17	2	2	NUM
finefocus-5274	76	18	-	-	PUNCT
finefocus-5274	76	19	hour	hour	NOUN
finefocus-5274	76	20	incubation	incubation	NOUN
finefocus-5274	76	21	period	period	NOUN
finefocus-5274	76	22	at	at	ADP
finefocus-5274	76	23	37	37	NUM
finefocus-5274	76	24	°	°	ADP
finefocus-5274	76	25	c	c	NOUN
finefocus-5274	76	26	with	with	ADP
finefocus-5274	76	27	aeration	aeration	NOUN
finefocus-5274	76	28	.	.	PUNCT
finefocus-5274	77	1	following	follow	VERB
finefocus-5274	77	2	incubation	incubation	NOUN
finefocus-5274	77	3	,	,	PUNCT
finefocus-5274	77	4	the	the	DET
finefocus-5274	77	5	entire	entire	ADJ
finefocus-5274	77	6	culture	culture	NOUN
finefocus-5274	77	7	was	be	AUX
finefocus-5274	77	8	pelleted	pellete	VERB
finefocus-5274	77	9	by	by	ADP
finefocus-5274	77	10	centrifugation	centrifugation	NOUN
finefocus-5274	77	11	at	at	ADP
finefocus-5274	77	12	approximately	approximately	ADV
finefocus-5274	77	13	7000	7000	NUM
finefocus-5274	77	14	rcf	rcf	NOUN
finefocus-5274	77	15	for	for	ADP
finefocus-5274	77	16	two	two	NUM
finefocus-5274	77	17	minutes	minute	NOUN
finefocus-5274	77	18	so	so	SCONJ
finefocus-5274	77	19	that	that	SCONJ
finefocus-5274	77	20	the	the	DET
finefocus-5274	77	21	latent	latent	NOUN
finefocus-5274	77	22	medium	medium	NOUN
finefocus-5274	77	23	could	could	AUX
finefocus-5274	77	24	be	be	AUX
finefocus-5274	77	25	removed	remove	VERB
finefocus-5274	77	26	,	,	PUNCT
finefocus-5274	77	27	and	and	CCONJ
finefocus-5274	77	28	the	the	DET
finefocus-5274	77	29	pellet	pellet	NOUN
finefocus-5274	77	30	was	be	AUX
finefocus-5274	77	31	resuspended	resuspend	VERB
finefocus-5274	77	32	in	in	ADP
finefocus-5274	77	33	150	150	NUM
finefocus-5274	77	34	µl	µl	NOUN
finefocus-5274	77	35	of	of	ADP
finefocus-5274	77	36	fresh	fresh	ADJ
finefocus-5274	77	37	lb	lb	NOUN
finefocus-5274	77	38	(	(	PUNCT
finefocus-5274	77	39	figure	figure	NOUN
finefocus-5274	77	40	2b	2b	NOUN
finefocus-5274	77	41	)	)	PUNCT
finefocus-5274	77	42	.	.	PUNCT
finefocus-5274	78	1	the	the	DET
finefocus-5274	78	2	resuspended	resuspend	VERB
finefocus-5274	78	3	culture	culture	NOUN
finefocus-5274	78	4	was	be	AUX
finefocus-5274	78	5	divided	divide	VERB
finefocus-5274	78	6	evenly	evenly	ADV
finefocus-5274	78	7	(	(	PUNCT
finefocus-5274	78	8	75	75	NUM
finefocus-5274	78	9	μl	μl	ADV
finefocus-5274	78	10	in	in	ADP
finefocus-5274	78	11	each	each	PRON
finefocus-5274	78	12	)	)	PUNCT
finefocus-5274	78	13	among	among	ADP
finefocus-5274	78	14	two	two	NUM
finefocus-5274	78	15	tubes	tube	NOUN
finefocus-5274	78	16	followed	follow	VERB
finefocus-5274	78	17	figure	figure	NOUN
finefocus-5274	78	18	3	3	NUM
finefocus-5274	78	19	.	.	PUNCT
finefocus-5274	78	20	mutation	mutation	NOUN
finefocus-5274	78	21	frequency	frequency	NOUN
finefocus-5274	78	22	of	of	ADP
finefocus-5274	78	23	gemcitabine	gemcitabine	NOUN
finefocus-5274	78	24	at	at	ADP
finefocus-5274	78	25	varying	vary	VERB
finefocus-5274	78	26	concentrations	concentration	NOUN
finefocus-5274	78	27	gemcitabine	gemcitabine	NOUN
finefocus-5274	78	28	was	be	AUX
finefocus-5274	78	29	tested	test	VERB
finefocus-5274	78	30	at	at	ADP
finefocus-5274	78	31	0.3	0.3	NUM
finefocus-5274	78	32	(	(	PUNCT
finefocus-5274	78	33	n=1	n=1	PROPN
finefocus-5274	78	34	)	)	PUNCT
finefocus-5274	78	35	,	,	PUNCT
finefocus-5274	78	36	0.5	0.5	NUM
finefocus-5274	78	37	(	(	PUNCT
finefocus-5274	78	38	n=1	n=1	PROPN
finefocus-5274	78	39	)	)	PUNCT
finefocus-5274	78	40	,	,	PUNCT
finefocus-5274	78	41	0.7	0.7	NUM
finefocus-5274	78	42	(	(	PUNCT
finefocus-5274	78	43	n=1	n=1	PROPN
finefocus-5274	78	44	)	)	PUNCT
finefocus-5274	78	45	,	,	PUNCT
finefocus-5274	78	46	and	and	CCONJ
finefocus-5274	78	47	0.9	0.9	NUM
finefocus-5274	78	48	μm	μm	NOUN
finefocus-5274	78	49	(	(	PUNCT
finefocus-5274	78	50	n=2	n=2	ADV
finefocus-5274	78	51	)	)	PUNCT
finefocus-5274	78	52	and	and	CCONJ
finefocus-5274	78	53	mutation	mutation	NOUN
finefocus-5274	78	54	frequency	frequency	NOUN
finefocus-5274	78	55	were	be	AUX
finefocus-5274	78	56	calculated	calculate	VERB
finefocus-5274	78	57	.	.	PUNCT
finefocus-5274	79	1	the	the	DET
finefocus-5274	79	2	fold	fold	ADJ
finefocus-5274	79	3	increase	increase	NOUN
finefocus-5274	79	4	of	of	ADP
finefocus-5274	79	5	the	the	DET
finefocus-5274	79	6	samples	sample	NOUN
finefocus-5274	79	7	was	be	AUX
finefocus-5274	79	8	0.67	0.67	NUM
finefocus-5274	79	9	,	,	PUNCT
finefocus-5274	79	10	1.14	1.14	NUM
finefocus-5274	79	11	,	,	PUNCT
finefocus-5274	79	12	0.93	0.93	NUM
finefocus-5274	79	13	,	,	PUNCT
finefocus-5274	79	14	and	and	CCONJ
finefocus-5274	79	15	1.14	1.14	NUM
finefocus-5274	79	16	respectively	respectively	ADV
finefocus-5274	79	17	compared	compare	VERB
finefocus-5274	79	18	to	to	ADP
finefocus-5274	79	19	the	the	DET
finefocus-5274	79	20	control	control	NOUN
finefocus-5274	79	21	showing	show	VERB
finefocus-5274	79	22	no	no	DET
finefocus-5274	79	23	statistical	statistical	ADJ
finefocus-5274	79	24	difference	difference	NOUN
finefocus-5274	79	25	.	.	PUNCT
finefocus-5274	80	1	error	error	NOUN
finefocus-5274	80	2	bars	bar	NOUN
finefocus-5274	80	3	represent	represent	VERB
finefocus-5274	80	4	95	95	NUM
finefocus-5274	80	5	%	%	NOUN
finefocus-5274	80	6	ci	ci	NOUN
finefocus-5274	80	7	based	base	VERB
finefocus-5274	80	8	on	on	ADP
finefocus-5274	80	9	the	the	DET
finefocus-5274	80	10	average	average	ADJ
finefocus-5274	80	11	mutation	mutation	NOUN
finefocus-5274	80	12	frequency	frequency	NOUN
finefocus-5274	80	13	.	.	PUNCT
finefocus-5274	81	1	fine	fine	ADJ
finefocus-5274	81	2	focus	focus	NOUN
finefocus-5274	81	3	|	|	ADV
finefocus-5274	81	4	volume	volume	NOUN
finefocus-5274	81	5	1118	1118	NUM
finefocus-5274	81	6	by	by	ADP
finefocus-5274	81	7	an	an	DET
finefocus-5274	81	8	addition	addition	NOUN
finefocus-5274	81	9	of	of	ADP
finefocus-5274	81	10	1.5	1.5	NUM
finefocus-5274	81	11	ml	ml	NOUN
finefocus-5274	81	12	of	of	ADP
finefocus-5274	81	13	fresh	fresh	ADJ
finefocus-5274	81	14	lb	lb	NOUN
finefocus-5274	81	15	to	to	ADP
finefocus-5274	81	16	each	each	DET
finefocus-5274	81	17	tube	tube	NOUN
finefocus-5274	81	18	(	(	PUNCT
finefocus-5274	81	19	figure	figure	NOUN
finefocus-5274	81	20	2c	2c	NUM
finefocus-5274	81	21	)	)	PUNCT
finefocus-5274	81	22	.	.	PUNCT
finefocus-5274	82	1	the	the	DET
finefocus-5274	82	2	specified	specified	ADJ
finefocus-5274	82	3	concentration	concentration	NOUN
finefocus-5274	82	4	of	of	ADP
finefocus-5274	82	5	the	the	DET
finefocus-5274	82	6	selected	select	VERB
finefocus-5274	82	7	drug	drug	NOUN
finefocus-5274	82	8	–	–	PUNCT
finefocus-5274	82	9	cpt-11	cpt-11	NUM
finefocus-5274	82	10	(	(	PUNCT
finefocus-5274	82	11	0.5	0.5	NUM
finefocus-5274	82	12	μm	μm	NUM
finefocus-5274	82	13	,	,	PUNCT
finefocus-5274	82	14	1	1	NUM
finefocus-5274	82	15	μm	μm	NUM
finefocus-5274	82	16	)	)	PUNCT
finefocus-5274	82	17	,	,	PUNCT
finefocus-5274	82	18	dexamethasone	dexamethasone	NOUN
finefocus-5274	82	19	(	(	PUNCT
finefocus-5274	82	20	60	60	NUM
finefocus-5274	82	21	μm	μm	NUM
finefocus-5274	82	22	)	)	PUNCT
finefocus-5274	82	23	,	,	PUNCT
finefocus-5274	82	24	ibuprofen	ibuprofen	NOUN
finefocus-5274	82	25	(	(	PUNCT
finefocus-5274	82	26	150	150	NUM
finefocus-5274	82	27	μm	μm	NUM
finefocus-5274	82	28	)	)	PUNCT
finefocus-5274	82	29	,	,	PUNCT
finefocus-5274	82	30	doxorubicin	doxorubicin	PROPN
finefocus-5274	82	31	(	(	PUNCT
finefocus-5274	82	32	0.025	0.025	NUM
finefocus-5274	82	33	μm	μm	NOUN
finefocus-5274	82	34	,	,	PUNCT
finefocus-5274	82	35	0.4	0.4	NUM
finefocus-5274	82	36	μm	μm	NUM
finefocus-5274	82	37	,	,	PUNCT
finefocus-5274	82	38	0.5	0.5	NUM
finefocus-5274	82	39	μm	μm	NUM
finefocus-5274	82	40	)	)	PUNCT
finefocus-5274	82	41	–	–	PUNCT
finefocus-5274	82	42	was	be	AUX
finefocus-5274	82	43	added	add	VERB
finefocus-5274	82	44	to	to	ADP
finefocus-5274	82	45	one	one	NUM
finefocus-5274	82	46	tube	tube	NOUN
finefocus-5274	82	47	while	while	SCONJ
finefocus-5274	82	48	an	an	DET
finefocus-5274	82	49	equal	equal	ADJ
finefocus-5274	82	50	amount	amount	NOUN
finefocus-5274	82	51	of	of	ADP
finefocus-5274	82	52	water	water	NOUN
finefocus-5274	82	53	was	be	AUX
finefocus-5274	82	54	added	add	VERB
finefocus-5274	82	55	to	to	ADP
finefocus-5274	82	56	the	the	DET
finefocus-5274	82	57	other	other	ADJ
finefocus-5274	82	58	tube	tube	NOUN
finefocus-5274	82	59	.	.	PUNCT
finefocus-5274	83	1	both	both	DET
finefocus-5274	83	2	tubes	tube	NOUN
finefocus-5274	83	3	were	be	AUX
finefocus-5274	83	4	placed	place	VERB
finefocus-5274	83	5	back	back	ADV
finefocus-5274	83	6	in	in	ADP
finefocus-5274	83	7	the	the	DET
finefocus-5274	83	8	incubator	incubator	NOUN
finefocus-5274	83	9	for	for	ADP
finefocus-5274	83	10	an	an	DET
finefocus-5274	83	11	additional	additional	ADJ
finefocus-5274	83	12	2	2	NUM
finefocus-5274	83	13	hours	hour	NOUN
finefocus-5274	83	14	to	to	PART
finefocus-5274	83	15	grow	grow	VERB
finefocus-5274	83	16	at	at	ADP
finefocus-5274	83	17	37	37	NUM
finefocus-5274	83	18	°	°	ADP
finefocus-5274	83	19	c	c	NOUN
finefocus-5274	83	20	with	with	ADP
finefocus-5274	83	21	aeration	aeration	NOUN
finefocus-5274	83	22	.	.	PUNCT
finefocus-5274	84	1	subsequently	subsequently	ADV
finefocus-5274	84	2	,	,	PUNCT
finefocus-5274	84	3	both	both	DET
finefocus-5274	84	4	cultures	culture	NOUN
finefocus-5274	84	5	were	be	AUX
finefocus-5274	84	6	pelleted	pellete	VERB
finefocus-5274	84	7	by	by	ADP
finefocus-5274	84	8	centrifugation	centrifugation	NOUN
finefocus-5274	84	9	once	once	ADV
finefocus-5274	84	10	more	more	ADV
finefocus-5274	84	11	and	and	CCONJ
finefocus-5274	84	12	the	the	DET
finefocus-5274	84	13	cell	cell	NOUN
finefocus-5274	84	14	pellet	pellet	NOUN
finefocus-5274	84	15	was	be	AUX
finefocus-5274	84	16	washed	wash	VERB
finefocus-5274	84	17	twice	twice	ADV
finefocus-5274	84	18	with	with	ADP
finefocus-5274	84	19	1	1	NUM
finefocus-5274	84	20	ml	ml	NOUN
finefocus-5274	84	21	lb	lb	NOUN
finefocus-5274	84	22	,	,	PUNCT
finefocus-5274	84	23	followed	follow	VERB
finefocus-5274	84	24	by	by	ADP
finefocus-5274	84	25	resuspension	resuspension	NOUN
finefocus-5274	84	26	in	in	ADP
finefocus-5274	84	27	200	200	NUM
finefocus-5274	84	28	,	,	PUNCT
finefocus-5274	84	29	400	400	NUM
finefocus-5274	84	30	,	,	PUNCT
finefocus-5274	84	31	or	or	CCONJ
finefocus-5274	84	32	600	600	NUM
finefocus-5274	84	33	μl	μl	ADV
finefocus-5274	84	34	lb	lb	NOUN
finefocus-5274	84	35	.	.	PUNCT
finefocus-5274	85	1	cultures	culture	NOUN
finefocus-5274	85	2	were	be	AUX
finefocus-5274	85	3	then	then	ADV
finefocus-5274	85	4	subject	subject	ADJ
finefocus-5274	85	5	to	to	ADP
finefocus-5274	85	6	serial	serial	ADJ
finefocus-5274	85	7	dilutions	dilution	NOUN
finefocus-5274	85	8	in	in	ADP
finefocus-5274	85	9	a	a	DET
finefocus-5274	85	10	96	96	NUM
finefocus-5274	85	11	-	-	PUNCT
finefocus-5274	85	12	well	well	NOUN
finefocus-5274	85	13	plate	plate	NOUN
finefocus-5274	85	14	to	to	PART
finefocus-5274	85	15	obtain	obtain	VERB
finefocus-5274	85	16	10	10	NUM
finefocus-5274	85	17	-	-	ADJ
finefocus-5274	85	18	fold	fold	ADJ
finefocus-5274	85	19	dilutions	dilution	NOUN
finefocus-5274	85	20	up	up	ADP
finefocus-5274	85	21	to	to	ADP
finefocus-5274	85	22	a	a	DET
finefocus-5274	85	23	1:100,000	1:100,000	NUM
finefocus-5274	85	24	dilution	dilution	NOUN
finefocus-5274	85	25	,	,	PUNCT
finefocus-5274	85	26	spotted	spot	VERB
finefocus-5274	85	27	onto	onto	ADP
finefocus-5274	85	28	lb	lb	PRON
finefocus-5274	85	29	and	and	CCONJ
finefocus-5274	85	30	minimum	minimum	ADJ
finefocus-5274	85	31	lactose	lactose	NOUN
finefocus-5274	85	32	plates	plate	NOUN
finefocus-5274	85	33	and	and	CCONJ
finefocus-5274	85	34	grown	grow	VERB
finefocus-5274	85	35	overnight	overnight	ADV
finefocus-5274	85	36	at	at	ADP
finefocus-5274	85	37	37	37	NUM
finefocus-5274	85	38	°	°	NOUN
finefocus-5274	85	39	c	c	NOUN
finefocus-5274	85	40	to	to	PART
finefocus-5274	85	41	determine	determine	VERB
finefocus-5274	85	42	the	the	DET
finefocus-5274	85	43	cfu	cfu	NOUN
finefocus-5274	85	44	(	(	PUNCT
finefocus-5274	85	45	colony	colony	NOUN
finefocus-5274	85	46	forming	form	VERB
finefocus-5274	85	47	units)/ml	units)/ml	ADV
finefocus-5274	85	48	(	(	PUNCT
finefocus-5274	85	49	figure	figure	NOUN
finefocus-5274	85	50	2d	2d	NUM
finefocus-5274	85	51	)	)	PUNCT
finefocus-5274	85	52	.	.	PUNCT
finefocus-5274	86	1	data	datum	NOUN
finefocus-5274	86	2	collection	collection	NOUN
finefocus-5274	86	3	and	and	CCONJ
finefocus-5274	86	4	analysis	analysis	NOUN
finefocus-5274	86	5	the	the	DET
finefocus-5274	86	6	percentage	percentage	NOUN
finefocus-5274	86	7	of	of	ADP
finefocus-5274	86	8	reverting	revert	VERB
finefocus-5274	86	9	cfus	cfus	NOUN
finefocus-5274	86	10	of	of	ADP
finefocus-5274	86	11	the	the	DET
finefocus-5274	86	12	total	total	NOUN
finefocus-5274	86	13	was	be	AUX
finefocus-5274	86	14	calculated	calculate	VERB
finefocus-5274	86	15	for	for	ADP
finefocus-5274	86	16	each	each	DET
finefocus-5274	86	17	drug	drug	NOUN
finefocus-5274	86	18	by	by	ADP
finefocus-5274	86	19	dividing	divide	VERB
finefocus-5274	86	20	the	the	DET
finefocus-5274	86	21	number	number	NOUN
finefocus-5274	86	22	of	of	ADP
finefocus-5274	86	23	total	total	ADJ
finefocus-5274	86	24	cfu	cfu	NOUN
finefocus-5274	86	25	/	/	SYM
finefocus-5274	86	26	ml	ml	X
finefocus-5274	86	27	on	on	ADP
finefocus-5274	86	28	the	the	DET
finefocus-5274	86	29	lac	lac	PROPN
finefocus-5274	86	30	plates	plate	NOUN
finefocus-5274	86	31	by	by	ADP
finefocus-5274	86	32	the	the	DET
finefocus-5274	86	33	number	number	NOUN
finefocus-5274	86	34	of	of	ADP
finefocus-5274	86	35	total	total	ADJ
finefocus-5274	86	36	cfu	cfu	NOUN
finefocus-5274	86	37	/	/	SYM
finefocus-5274	86	38	ml	ml	X
finefocus-5274	86	39	on	on	ADP
finefocus-5274	86	40	the	the	DET
finefocus-5274	86	41	lb	lb	ADJ
finefocus-5274	86	42	plates	plate	NOUN
finefocus-5274	86	43	(	(	PUNCT
finefocus-5274	86	44	figure	figure	NOUN
finefocus-5274	86	45	2e	2e	NUM
finefocus-5274	86	46	)	)	PUNCT
finefocus-5274	86	47	.	.	PUNCT
finefocus-5274	87	1	all	all	DET
finefocus-5274	87	2	corresponding	correspond	VERB
finefocus-5274	87	3	data	datum	NOUN
finefocus-5274	87	4	points	point	NOUN
finefocus-5274	87	5	were	be	AUX
finefocus-5274	87	6	averaged	average	VERB
finefocus-5274	87	7	to	to	PART
finefocus-5274	87	8	obtain	obtain	VERB
finefocus-5274	87	9	the	the	DET
finefocus-5274	87	10	average	average	ADJ
finefocus-5274	87	11	mutation	mutation	NOUN
finefocus-5274	87	12	frequency	frequency	NOUN
finefocus-5274	87	13	of	of	ADP
finefocus-5274	87	14	each	each	DET
finefocus-5274	87	15	drug	drug	NOUN
finefocus-5274	87	16	.	.	PUNCT
finefocus-5274	88	1	statistical	statistical	ADJ
finefocus-5274	88	2	analysis	analysis	NOUN
finefocus-5274	88	3	was	be	AUX
finefocus-5274	88	4	done	do	VERB
finefocus-5274	88	5	using	use	VERB
finefocus-5274	88	6	an	an	DET
finefocus-5274	88	7	unpaired	unpaired	ADJ
finefocus-5274	88	8	t	t	NOUN
finefocus-5274	88	9	-	-	PUNCT
finefocus-5274	88	10	test	test	NOUN
finefocus-5274	88	11	that	that	PRON
finefocus-5274	88	12	does	do	AUX
finefocus-5274	88	13	not	not	PART
finefocus-5274	88	14	assume	assume	VERB
finefocus-5274	88	15	equal	equal	ADJ
finefocus-5274	88	16	standard	standard	ADJ
finefocus-5274	88	17	deviation	deviation	NOUN
finefocus-5274	88	18	among	among	ADP
finefocus-5274	88	19	populations	population	NOUN
finefocus-5274	88	20	(	(	PUNCT
finefocus-5274	88	21	welch	welch	PROPN
finefocus-5274	88	22	’s	’s	PART
finefocus-5274	88	23	t	t	PROPN
finefocus-5274	88	24	-	-	PUNCT
finefocus-5274	88	25	test	test	NOUN
finefocus-5274	88	26	)	)	PUNCT
finefocus-5274	88	27	using	use	VERB
finefocus-5274	88	28	graphpad	graphpad	NOUN
finefocus-5274	88	29	prism	prism	NOUN
finefocus-5274	88	30	version	version	PROPN
finefocus-5274	88	31	10.2.0	10.2.0	PROPN
finefocus-5274	88	32	for	for	ADP
finefocus-5274	88	33	windows	window	NOUN
finefocus-5274	88	34	,	,	PUNCT
finefocus-5274	88	35	graphpad	graphpad	NOUN
finefocus-5274	88	36	software	software	NOUN
finefocus-5274	88	37	,	,	PUNCT
finefocus-5274	88	38	boston	boston	PROPN
finefocus-5274	88	39	,	,	PUNCT
finefocus-5274	88	40	massachusetts	massachusetts	PROPN
finefocus-5274	88	41	usa	usa	PROPN
finefocus-5274	88	42	,	,	PUNCT
finefocus-5274	88	43	www.graphpad.com	www.graphpad.com	PROPN
finefocus-5274	88	44	.	.	PUNCT
finefocus-5274	89	1	figure	figure	NOUN
finefocus-5274	89	2	4	4	NUM
finefocus-5274	89	3	.	.	PUNCT
finefocus-5274	89	4	mutation	mutation	NOUN
finefocus-5274	89	5	frequency	frequency	NOUN
finefocus-5274	89	6	of	of	ADP
finefocus-5274	89	7	ibuprofen	ibuprofen	NOUN
finefocus-5274	89	8	at	at	ADP
finefocus-5274	89	9	150	150	NUM
finefocus-5274	89	10	μm	μm	NOUN
finefocus-5274	89	11	ibuprofen	ibuprofen	NOUN
finefocus-5274	89	12	demonstrated	demonstrate	VERB
finefocus-5274	89	13	a	a	DET
finefocus-5274	89	14	fold	fold	ADJ
finefocus-5274	89	15	increase	increase	NOUN
finefocus-5274	89	16	of	of	ADP
finefocus-5274	89	17	0.74	0.74	NUM
finefocus-5274	89	18	compared	compare	VERB
finefocus-5274	89	19	to	to	ADP
finefocus-5274	89	20	the	the	DET
finefocus-5274	89	21	control	control	NOUN
finefocus-5274	89	22	(	(	PUNCT
finefocus-5274	89	23	n=3	n=3	NOUN
finefocus-5274	89	24	)	)	PUNCT
finefocus-5274	89	25	.	.	PUNCT
finefocus-5274	90	1	this	this	PRON
finefocus-5274	90	2	was	be	AUX
finefocus-5274	90	3	not	not	PART
finefocus-5274	90	4	statistically	statistically	ADV
finefocus-5274	90	5	different	different	ADJ
finefocus-5274	90	6	than	than	ADP
finefocus-5274	90	7	the	the	DET
finefocus-5274	90	8	control	control	NOUN
finefocus-5274	90	9	group	group	NOUN
finefocus-5274	90	10	.	.	PUNCT
finefocus-5274	91	1	error	error	NOUN
finefocus-5274	91	2	bars	bar	NOUN
finefocus-5274	91	3	represent	represent	VERB
finefocus-5274	91	4	95	95	NUM
finefocus-5274	91	5	%	%	NOUN
finefocus-5274	91	6	ci	ci	NOUN
finefocus-5274	91	7	based	base	VERB
finefocus-5274	91	8	on	on	ADP
finefocus-5274	91	9	the	the	DET
finefocus-5274	91	10	average	average	ADJ
finefocus-5274	91	11	mutation	mutation	NOUN
finefocus-5274	91	12	frequency	frequency	NOUN
finefocus-5274	91	13	.	.	PUNCT
finefocus-5274	91	14	http://www.graphpad.com	http://www.graphpad.com	X
finefocus-5274	92	1	swain	swain	PROPN
finefocus-5274	92	2	et	et	PROPN
finefocus-5274	92	3	al	al	PROPN
finefocus-5274	92	4	.	.	PUNCT
finefocus-5274	93	1	|	|	ADV
finefocus-5274	93	2	analyzing	analyze	VERB
finefocus-5274	93	3	selected	select	VERB
finefocus-5274	93	4	fda	fda	PROPN
finefocus-5274	93	5	approved	approve	VERB
finefocus-5274	93	6	drugs	drug	NOUN
finefocus-5274	93	7	for	for	ADP
finefocus-5274	93	8	effects	effect	NOUN
finefocus-5274	93	9	on	on	ADP
finefocus-5274	93	10	template	template	NOUN
finefocus-5274	93	11	switch	switch	NOUN
finefocus-5274	93	12	mutagenesis	mutagenesis	NOUN
finefocus-5274	93	13	in	in	ADP
finefocus-5274	93	14	e.	e.	PROPN
finefocus-5274	93	15	coli	coli	PROPN
finefocus-5274	93	16	19	19	NUM
finefocus-5274	93	17	results	result	NOUN
finefocus-5274	93	18	of	of	ADP
finefocus-5274	93	19	the	the	DET
finefocus-5274	93	20	four	four	NUM
finefocus-5274	93	21	concentrations	concentration	NOUN
finefocus-5274	93	22	of	of	ADP
finefocus-5274	93	23	gemcitabine	gemcitabine	NOUN
finefocus-5274	93	24	hydrochloride	hydrochloride	NOUN
finefocus-5274	93	25	tested	test	VERB
finefocus-5274	93	26	(	(	PUNCT
finefocus-5274	93	27	0.3	0.3	NUM
finefocus-5274	93	28	μm	μm	NOUN
finefocus-5274	93	29	,	,	PUNCT
finefocus-5274	93	30	0.5	0.5	NUM
finefocus-5274	93	31	μm	μm	NUM
finefocus-5274	93	32	,	,	PUNCT
finefocus-5274	93	33	0.7	0.7	NUM
finefocus-5274	93	34	μm	μm	NOUN
finefocus-5274	93	35	,	,	PUNCT
finefocus-5274	93	36	and	and	CCONJ
finefocus-5274	93	37	0.9	0.9	NUM
finefocus-5274	93	38	μm	μm	NUM
finefocus-5274	93	39	)	)	PUNCT
finefocus-5274	93	40	,	,	PUNCT
finefocus-5274	93	41	the	the	DET
finefocus-5274	93	42	fold	fold	ADJ
finefocus-5274	93	43	change	change	NOUN
finefocus-5274	93	44	was	be	AUX
finefocus-5274	93	45	only	only	ADV
finefocus-5274	93	46	between	between	ADP
finefocus-5274	93	47	0.67	0.67	NUM
finefocus-5274	93	48	and	and	CCONJ
finefocus-5274	93	49	1.14	1.14	NUM
finefocus-5274	93	50	(	(	PUNCT
finefocus-5274	93	51	figure	figure	NOUN
finefocus-5274	93	52	3	3	NUM
finefocus-5274	93	53	)	)	PUNCT
finefocus-5274	93	54	showing	show	VERB
finefocus-5274	93	55	no	no	DET
finefocus-5274	93	56	statistical	statistical	ADJ
finefocus-5274	93	57	difference	difference	NOUN
finefocus-5274	93	58	from	from	ADP
finefocus-5274	93	59	the	the	DET
finefocus-5274	93	60	control	control	NOUN
finefocus-5274	93	61	group	group	NOUN
finefocus-5274	93	62	.	.	PUNCT
finefocus-5274	94	1	similarly	similarly	ADV
finefocus-5274	94	2	,	,	PUNCT
finefocus-5274	94	3	ibuprofen	ibuprofen	PROPN
finefocus-5274	94	4	showed	show	VERB
finefocus-5274	94	5	a	a	DET
finefocus-5274	94	6	fold	fold	ADJ
finefocus-5274	94	7	change	change	NOUN
finefocus-5274	94	8	of	of	ADP
finefocus-5274	94	9	0.74	0.74	NUM
finefocus-5274	94	10	and	and	CCONJ
finefocus-5274	94	11	no	no	DET
finefocus-5274	94	12	statistical	statistical	ADJ
finefocus-5274	94	13	difference	difference	NOUN
finefocus-5274	94	14	from	from	ADP
finefocus-5274	94	15	the	the	DET
finefocus-5274	94	16	control	control	NOUN
finefocus-5274	94	17	(	(	PUNCT
finefocus-5274	94	18	figure	figure	NOUN
finefocus-5274	94	19	4	4	NUM
finefocus-5274	94	20	)	)	PUNCT
finefocus-5274	94	21	.	.	PUNCT
finefocus-5274	95	1	when	when	SCONJ
finefocus-5274	95	2	compared	compare	VERB
finefocus-5274	95	3	to	to	ADP
finefocus-5274	95	4	the	the	DET
finefocus-5274	95	5	control	control	NOUN
finefocus-5274	95	6	group	group	NOUN
finefocus-5274	95	7	,	,	PUNCT
finefocus-5274	95	8	dexamethasone	dexamethasone	NOUN
finefocus-5274	95	9	resulted	result	VERB
finefocus-5274	95	10	in	in	ADP
finefocus-5274	95	11	a	a	DET
finefocus-5274	95	12	lower	low	ADJ
finefocus-5274	95	13	average	average	ADJ
finefocus-5274	95	14	rate	rate	NOUN
finefocus-5274	95	15	of	of	ADP
finefocus-5274	95	16	templateswitch	templateswitch	NOUN
finefocus-5274	95	17	mutations	mutation	NOUN
finefocus-5274	95	18	,	,	PUNCT
finefocus-5274	95	19	though	though	SCONJ
finefocus-5274	95	20	not	not	PART
finefocus-5274	95	21	statistically	statistically	ADV
finefocus-5274	95	22	different	different	ADJ
finefocus-5274	95	23	from	from	ADP
finefocus-5274	95	24	the	the	DET
finefocus-5274	95	25	control	control	NOUN
finefocus-5274	95	26	.	.	PUNCT
finefocus-5274	96	1	dexamethasone	dexamethasone	NOUN
finefocus-5274	96	2	was	be	AUX
finefocus-5274	96	3	tested	test	VERB
finefocus-5274	96	4	at	at	ADP
finefocus-5274	96	5	a	a	DET
finefocus-5274	96	6	concentration	concentration	NOUN
finefocus-5274	96	7	of	of	ADP
finefocus-5274	96	8	60	60	NUM
finefocus-5274	96	9	μm	μm	NUM
finefocus-5274	96	10	and	and	CCONJ
finefocus-5274	96	11	resulted	result	VERB
finefocus-5274	96	12	in	in	ADP
finefocus-5274	96	13	a	a	DET
finefocus-5274	96	14	2.37	2.37	NUM
finefocus-5274	96	15	-	-	ADJ
finefocus-5274	96	16	fold	fold	ADJ
finefocus-5274	96	17	change	change	NOUN
finefocus-5274	96	18	in	in	ADP
finefocus-5274	96	19	mutation	mutation	NOUN
finefocus-5274	96	20	frequency	frequency	NOUN
finefocus-5274	96	21	,	,	PUNCT
finefocus-5274	96	22	with	with	ADP
finefocus-5274	96	23	the	the	DET
finefocus-5274	96	24	average	average	ADJ
finefocus-5274	96	25	rate	rate	NOUN
finefocus-5274	96	26	of	of	ADP
finefocus-5274	96	27	mutation	mutation	NOUN
finefocus-5274	96	28	1.56e-06	1.56e-06	NUM
finefocus-5274	96	29	compared	compare	VERB
finefocus-5274	96	30	to	to	ADP
finefocus-5274	96	31	the	the	DET
finefocus-5274	96	32	control	control	NOUN
finefocus-5274	96	33	of	of	ADP
finefocus-5274	96	34	3.71e-06	3.71e-06	NUM
finefocus-5274	96	35	(	(	PUNCT
finefocus-5274	96	36	figure	figure	NOUN
finefocus-5274	96	37	5	5	NUM
finefocus-5274	96	38	)	)	PUNCT
finefocus-5274	96	39	.	.	PUNCT
finefocus-5274	97	1	this	this	PRON
finefocus-5274	97	2	was	be	AUX
finefocus-5274	97	3	similar	similar	ADJ
finefocus-5274	97	4	to	to	ADP
finefocus-5274	97	5	the	the	DET
finefocus-5274	97	6	results	result	NOUN
finefocus-5274	97	7	of	of	ADP
finefocus-5274	97	8	doxorubicin	doxorubicin	PROPN
finefocus-5274	97	9	hydrochloride	hydrochloride	NOUN
finefocus-5274	97	10	at	at	ADP
finefocus-5274	97	11	a	a	DET
finefocus-5274	97	12	concentration	concentration	NOUN
finefocus-5274	97	13	of	of	ADP
finefocus-5274	97	14	0.4	0.4	NUM
finefocus-5274	97	15	μm	μm	NOUN
finefocus-5274	97	16	which	which	PRON
finefocus-5274	97	17	had	have	VERB
finefocus-5274	97	18	a	a	DET
finefocus-5274	97	19	fold	fold	ADJ
finefocus-5274	97	20	change	change	NOUN
finefocus-5274	97	21	of	of	ADP
finefocus-5274	97	22	2.41	2.41	NUM
finefocus-5274	97	23	and	and	CCONJ
finefocus-5274	97	24	an	an	DET
finefocus-5274	97	25	average	average	ADJ
finefocus-5274	97	26	rate	rate	NOUN
finefocus-5274	97	27	of	of	ADP
finefocus-5274	97	28	mutation	mutation	NOUN
finefocus-5274	97	29	of	of	ADP
finefocus-5274	97	30	1.54e-06	1.54e-06	NUM
finefocus-5274	97	31	(	(	PUNCT
finefocus-5274	97	32	figure	figure	NOUN
finefocus-5274	97	33	5	5	NUM
finefocus-5274	97	34	)	)	PUNCT
finefocus-5274	97	35	.	.	PUNCT
finefocus-5274	98	1	testing	testing	NOUN
finefocus-5274	98	2	done	do	VERB
finefocus-5274	98	3	with	with	ADP
finefocus-5274	98	4	cpt-11	cpt-11	PROPN
finefocus-5274	98	5	showed	show	VERB
finefocus-5274	98	6	a	a	DET
finefocus-5274	98	7	statistically	statistically	ADV
finefocus-5274	98	8	significant	significant	ADJ
finefocus-5274	98	9	(	(	PUNCT
finefocus-5274	98	10	p=0.0383	p=0.0383	PROPN
finefocus-5274	98	11	)	)	PUNCT
finefocus-5274	98	12	change	change	NOUN
finefocus-5274	98	13	in	in	ADP
finefocus-5274	98	14	reported	report	VERB
finefocus-5274	98	15	template	template	NOUN
finefocus-5274	98	16	-	-	PUNCT
finefocus-5274	98	17	switch	switch	NOUN
finefocus-5274	98	18	mutation	mutation	NOUN
finefocus-5274	98	19	rate	rate	NOUN
finefocus-5274	98	20	,	,	PUNCT
finefocus-5274	98	21	producing	produce	VERB
finefocus-5274	98	22	a	a	DET
finefocus-5274	98	23	3.08	3.08	NUM
finefocus-5274	98	24	-	-	ADJ
finefocus-5274	98	25	fold	fold	ADJ
finefocus-5274	98	26	decrease	decrease	NOUN
finefocus-5274	98	27	when	when	SCONJ
finefocus-5274	98	28	tested	test	VERB
finefocus-5274	98	29	at	at	ADP
finefocus-5274	98	30	a	a	DET
finefocus-5274	98	31	concentration	concentration	NOUN
finefocus-5274	98	32	of	of	ADP
finefocus-5274	98	33	0.5	0.5	NUM
finefocus-5274	98	34	μm	μm	NOUN
finefocus-5274	98	35	with	with	ADP
finefocus-5274	98	36	an	an	DET
finefocus-5274	98	37	average	average	ADJ
finefocus-5274	98	38	rate	rate	NOUN
finefocus-5274	98	39	of	of	ADP
finefocus-5274	98	40	mutation	mutation	NOUN
finefocus-5274	98	41	of	of	ADP
finefocus-5274	98	42	1.20e-06	1.20e-06	NUM
finefocus-5274	98	43	(	(	PUNCT
finefocus-5274	98	44	figure	figure	NOUN
finefocus-5274	98	45	5	5	NUM
finefocus-5274	98	46	)	)	PUNCT
finefocus-5274	98	47	.	.	PUNCT
finefocus-5274	99	1	figure	figure	NOUN
finefocus-5274	99	2	5	5	NUM
finefocus-5274	99	3	.	.	PUNCT
finefocus-5274	99	4	comparison	comparison	NOUN
finefocus-5274	99	5	of	of	ADP
finefocus-5274	99	6	mutation	mutation	NOUN
finefocus-5274	99	7	frequency	frequency	NOUN
finefocus-5274	99	8	of	of	ADP
finefocus-5274	99	9	cpt-11	cpt-11	PROPN
finefocus-5274	99	10	,	,	PUNCT
finefocus-5274	99	11	dexamethasone	dexamethasone	NOUN
finefocus-5274	99	12	,	,	PUNCT
finefocus-5274	99	13	and	and	CCONJ
finefocus-5274	99	14	doxorubicin	doxorubicin	PROPN
finefocus-5274	99	15	cpt-11	cpt-11	PROPN
finefocus-5274	99	16	was	be	AUX
finefocus-5274	99	17	tested	test	VERB
finefocus-5274	99	18	at	at	ADP
finefocus-5274	99	19	a	a	DET
finefocus-5274	99	20	concentration	concentration	NOUN
finefocus-5274	99	21	of	of	ADP
finefocus-5274	99	22	0.5	0.5	NUM
finefocus-5274	99	23	μm	μm	NOUN
finefocus-5274	99	24	(	(	PUNCT
finefocus-5274	99	25	n=17	n=17	PROPN
finefocus-5274	99	26	)	)	PUNCT
finefocus-5274	99	27	and	and	CCONJ
finefocus-5274	99	28	resulted	result	VERB
finefocus-5274	99	29	in	in	ADP
finefocus-5274	99	30	a	a	DET
finefocus-5274	99	31	statistically	statistically	ADV
finefocus-5274	99	32	significant	significant	ADJ
finefocus-5274	99	33	fold	fold	ADJ
finefocus-5274	99	34	change	change	NOUN
finefocus-5274	99	35	of	of	ADP
finefocus-5274	99	36	3.08	3.08	NUM
finefocus-5274	99	37	compared	compare	VERB
finefocus-5274	99	38	to	to	ADP
finefocus-5274	99	39	the	the	DET
finefocus-5274	99	40	control	control	NOUN
finefocus-5274	99	41	with	with	ADP
finefocus-5274	99	42	a	a	DET
finefocus-5274	99	43	p	p	NOUN
finefocus-5274	99	44	-	-	PUNCT
finefocus-5274	99	45	value	value	NOUN
finefocus-5274	99	46	of	of	ADP
finefocus-5274	99	47	0.0383	0.0383	NUM
finefocus-5274	99	48	.	.	PUNCT
finefocus-5274	100	1	dexamethasone	dexamethasone	NOUN
finefocus-5274	100	2	,	,	PUNCT
finefocus-5274	100	3	at	at	ADP
finefocus-5274	100	4	a	a	DET
finefocus-5274	100	5	concentration	concentration	NOUN
finefocus-5274	100	6	of	of	ADP
finefocus-5274	100	7	60	60	NUM
finefocus-5274	100	8	μm	μm	NOUN
finefocus-5274	100	9	(	(	PUNCT
finefocus-5274	100	10	n=5	n=5	NUM
finefocus-5274	100	11	)	)	PUNCT
finefocus-5274	100	12	,	,	PUNCT
finefocus-5274	100	13	showed	show	VERB
finefocus-5274	100	14	a	a	DET
finefocus-5274	100	15	statistically	statistically	ADV
finefocus-5274	100	16	insignificant	insignificant	ADJ
finefocus-5274	100	17	fold	fold	ADJ
finefocus-5274	100	18	change	change	NOUN
finefocus-5274	100	19	of	of	ADP
finefocus-5274	100	20	2.37	2.37	NUM
finefocus-5274	100	21	compared	compare	VERB
finefocus-5274	100	22	to	to	ADP
finefocus-5274	100	23	the	the	DET
finefocus-5274	100	24	control	control	NOUN
finefocus-5274	100	25	.	.	PUNCT
finefocus-5274	101	1	doxorubicin	doxorubicin	PROPN
finefocus-5274	101	2	was	be	AUX
finefocus-5274	101	3	also	also	ADV
finefocus-5274	101	4	statistically	statistically	ADV
finefocus-5274	101	5	insignificant	insignificant	ADJ
finefocus-5274	101	6	,	,	PUNCT
finefocus-5274	101	7	tested	test	VERB
finefocus-5274	101	8	at	at	ADP
finefocus-5274	101	9	a	a	DET
finefocus-5274	101	10	concentration	concentration	NOUN
finefocus-5274	101	11	of	of	ADP
finefocus-5274	101	12	0.4	0.4	NUM
finefocus-5274	101	13	μm	μm	NOUN
finefocus-5274	101	14	(	(	PUNCT
finefocus-5274	101	15	n=24	n=24	PROPN
finefocus-5274	101	16	)	)	PUNCT
finefocus-5274	101	17	and	and	CCONJ
finefocus-5274	101	18	displaying	display	VERB
finefocus-5274	101	19	a	a	DET
finefocus-5274	101	20	fold	fold	ADJ
finefocus-5274	101	21	change	change	NOUN
finefocus-5274	101	22	of	of	ADP
finefocus-5274	101	23	2.41	2.41	NUM
finefocus-5274	101	24	compared	compare	VERB
finefocus-5274	101	25	to	to	ADP
finefocus-5274	101	26	the	the	DET
finefocus-5274	101	27	control	control	NOUN
finefocus-5274	101	28	.	.	PUNCT
finefocus-5274	102	1	error	error	NOUN
finefocus-5274	102	2	bars	bar	NOUN
finefocus-5274	102	3	represent	represent	VERB
finefocus-5274	102	4	95	95	NUM
finefocus-5274	102	5	%	%	NOUN
finefocus-5274	102	6	ci	ci	NOUN
finefocus-5274	102	7	based	base	VERB
finefocus-5274	102	8	on	on	ADP
finefocus-5274	102	9	the	the	DET
finefocus-5274	102	10	average	average	ADJ
finefocus-5274	102	11	mutation	mutation	NOUN
finefocus-5274	102	12	frequency	frequency	NOUN
finefocus-5274	102	13	.	.	PUNCT
finefocus-5274	103	1	fine	fine	ADJ
finefocus-5274	103	2	focus	focus	NOUN
finefocus-5274	103	3	|	|	ADV
finefocus-5274	103	4	volume	volume	VERB
finefocus-5274	103	5	1120	1120	NUM
finefocus-5274	103	6	discussion	discussion	NOUN
finefocus-5274	103	7	this	this	DET
finefocus-5274	103	8	study	study	NOUN
finefocus-5274	103	9	aims	aim	VERB
finefocus-5274	103	10	to	to	PART
finefocus-5274	103	11	expand	expand	VERB
finefocus-5274	103	12	our	our	PRON
finefocus-5274	103	13	understanding	understanding	NOUN
finefocus-5274	103	14	of	of	ADP
finefocus-5274	103	15	which	which	PRON
finefocus-5274	103	16	fda	fda	PROPN
finefocus-5274	103	17	-	-	PUNCT
finefocus-5274	103	18	approved	approve	VERB
finefocus-5274	103	19	drugs	drug	NOUN
finefocus-5274	103	20	contribute	contribute	VERB
finefocus-5274	103	21	to	to	ADP
finefocus-5274	103	22	tsm	tsm	NOUN
finefocus-5274	103	23	.	.	PUNCT
finefocus-5274	104	1	it	it	PRON
finefocus-5274	104	2	is	be	AUX
finefocus-5274	104	3	important	important	ADJ
finefocus-5274	104	4	to	to	PART
finefocus-5274	104	5	examine	examine	VERB
finefocus-5274	104	6	how	how	SCONJ
finefocus-5274	104	7	these	these	DET
finefocus-5274	104	8	therapeutics	therapeutic	NOUN
finefocus-5274	104	9	,	,	PUNCT
finefocus-5274	104	10	including	include	VERB
finefocus-5274	104	11	some	some	DET
finefocus-5274	104	12	commonly	commonly	ADV
finefocus-5274	104	13	used	use	VERB
finefocus-5274	104	14	over	over	ADP
finefocus-5274	104	15	-	-	PUNCT
finefocus-5274	104	16	the	the	DET
finefocus-5274	104	17	-	-	PUNCT
finefocus-5274	104	18	counter	counter	NOUN
finefocus-5274	104	19	drugs	drug	NOUN
finefocus-5274	104	20	,	,	PUNCT
finefocus-5274	104	21	may	may	AUX
finefocus-5274	104	22	affect	affect	VERB
finefocus-5274	104	23	mutation	mutation	NOUN
finefocus-5274	104	24	frequency	frequency	NOUN
finefocus-5274	104	25	,	,	PUNCT
finefocus-5274	104	26	as	as	SCONJ
finefocus-5274	104	27	tsm	tsm	NOUN
finefocus-5274	104	28	have	have	AUX
finefocus-5274	104	29	been	be	AUX
finefocus-5274	104	30	linked	link	VERB
finefocus-5274	104	31	to	to	ADP
finefocus-5274	104	32	the	the	DET
finefocus-5274	104	33	development	development	NOUN
finefocus-5274	104	34	of	of	ADP
finefocus-5274	104	35	various	various	ADJ
finefocus-5274	104	36	diseases	disease	NOUN
finefocus-5274	104	37	.	.	PUNCT
finefocus-5274	105	1	there	there	PRON
finefocus-5274	105	2	is	be	VERB
finefocus-5274	105	3	still	still	ADV
finefocus-5274	105	4	a	a	DET
finefocus-5274	105	5	significant	significant	ADJ
finefocus-5274	105	6	gap	gap	NOUN
finefocus-5274	105	7	in	in	ADP
finefocus-5274	105	8	understanding	understand	VERB
finefocus-5274	105	9	tsm	tsm	NOUN
finefocus-5274	105	10	,	,	PUNCT
finefocus-5274	105	11	their	their	PRON
finefocus-5274	105	12	causes	cause	NOUN
finefocus-5274	105	13	,	,	PUNCT
finefocus-5274	105	14	and	and	CCONJ
finefocus-5274	105	15	the	the	DET
finefocus-5274	105	16	mechanisms	mechanism	NOUN
finefocus-5274	105	17	behind	behind	ADP
finefocus-5274	105	18	these	these	DET
finefocus-5274	105	19	mutations	mutation	NOUN
finefocus-5274	105	20	.	.	PUNCT
finefocus-5274	106	1	the	the	DET
finefocus-5274	106	2	expected	expect	VERB
finefocus-5274	106	3	outcomes	outcome	NOUN
finefocus-5274	106	4	for	for	ADP
finefocus-5274	106	5	these	these	DET
finefocus-5274	106	6	experimental	experimental	ADJ
finefocus-5274	106	7	drugs	drug	NOUN
finefocus-5274	106	8	were	be	AUX
finefocus-5274	106	9	that	that	SCONJ
finefocus-5274	106	10	they	they	PRON
finefocus-5274	106	11	would	would	AUX
finefocus-5274	106	12	either	either	CCONJ
finefocus-5274	106	13	inhibit	inhibit	VERB
finefocus-5274	106	14	a	a	DET
finefocus-5274	106	15	process	process	NOUN
finefocus-5274	106	16	during	during	ADP
finefocus-5274	106	17	dna	dna	NOUN
finefocus-5274	106	18	replication	replication	NOUN
finefocus-5274	106	19	or	or	CCONJ
finefocus-5274	106	20	act	act	NOUN
finefocus-5274	106	21	as	as	ADP
finefocus-5274	106	22	intercalating	intercalate	VERB
finefocus-5274	106	23	agents	agent	NOUN
finefocus-5274	106	24	to	to	PART
finefocus-5274	106	25	disrupt	disrupt	VERB
finefocus-5274	106	26	dna	dna	PROPN
finefocus-5274	106	27	,	,	PUNCT
finefocus-5274	106	28	leading	lead	VERB
finefocus-5274	106	29	to	to	ADP
finefocus-5274	106	30	an	an	DET
finefocus-5274	106	31	increase	increase	NOUN
finefocus-5274	106	32	in	in	ADP
finefocus-5274	106	33	tsm	tsm	NOUN
finefocus-5274	106	34	frequency	frequency	NOUN
finefocus-5274	106	35	.	.	PUNCT
finefocus-5274	107	1	however	however	ADV
finefocus-5274	107	2	,	,	PUNCT
finefocus-5274	107	3	for	for	ADP
finefocus-5274	107	4	most	most	ADJ
finefocus-5274	107	5	of	of	ADP
finefocus-5274	107	6	the	the	DET
finefocus-5274	107	7	drugs	drug	NOUN
finefocus-5274	107	8	tested	test	VERB
finefocus-5274	107	9	(	(	PUNCT
finefocus-5274	107	10	ibuprofen	ibuprofen	NOUN
finefocus-5274	107	11	,	,	PUNCT
finefocus-5274	107	12	dexamethasone	dexamethasone	NOUN
finefocus-5274	107	13	,	,	PUNCT
finefocus-5274	107	14	doxorubicin	doxorubicin	PROPN
finefocus-5274	107	15	hydrochloride	hydrochloride	NOUN
finefocus-5274	107	16	,	,	PUNCT
finefocus-5274	107	17	and	and	CCONJ
finefocus-5274	107	18	gemcitabine	gemcitabine	NOUN
finefocus-5274	107	19	hydrochloride	hydrochloride	NOUN
finefocus-5274	107	20	)	)	PUNCT
finefocus-5274	107	21	,	,	PUNCT
finefocus-5274	107	22	no	no	DET
finefocus-5274	107	23	statistically	statistically	ADV
finefocus-5274	107	24	significant	significant	ADJ
finefocus-5274	107	25	change	change	NOUN
finefocus-5274	107	26	in	in	ADP
finefocus-5274	107	27	mutation	mutation	NOUN
finefocus-5274	107	28	frequency	frequency	NOUN
finefocus-5274	107	29	was	be	AUX
finefocus-5274	107	30	observed	observe	VERB
finefocus-5274	107	31	.	.	PUNCT
finefocus-5274	108	1	our	our	PRON
finefocus-5274	108	2	preliminary	preliminary	ADJ
finefocus-5274	108	3	investigation	investigation	NOUN
finefocus-5274	108	4	into	into	ADP
finefocus-5274	108	5	the	the	DET
finefocus-5274	108	6	effects	effect	NOUN
finefocus-5274	108	7	of	of	ADP
finefocus-5274	108	8	gemcitabine	gemcitabine	NOUN
finefocus-5274	108	9	hydrochloride	hydrochloride	NOUN
finefocus-5274	108	10	on	on	ADP
finefocus-5274	108	11	tsm	tsm	NOUN
finefocus-5274	108	12	frequency	frequency	NOUN
finefocus-5274	108	13	suggests	suggest	VERB
finefocus-5274	108	14	no	no	DET
finefocus-5274	108	15	significant	significant	ADJ
finefocus-5274	108	16	impact	impact	NOUN
finefocus-5274	108	17	on	on	ADP
finefocus-5274	108	18	the	the	DET
finefocus-5274	108	19	leading	lead	VERB
finefocus-5274	108	20	strand	strand	NOUN
finefocus-5274	108	21	.	.	PUNCT
finefocus-5274	109	1	contrary	contrary	ADJ
finefocus-5274	109	2	to	to	ADP
finefocus-5274	109	3	the	the	DET
finefocus-5274	109	4	initial	initial	ADJ
finefocus-5274	109	5	hypothesis	hypothesis	NOUN
finefocus-5274	109	6	,	,	PUNCT
finefocus-5274	109	7	due	due	ADJ
finefocus-5274	109	8	to	to	PART
finefocus-5274	109	9	gemcitabine	gemcitabine	VERB
finefocus-5274	109	10	hydrochloride	hydrochloride	NOUN
finefocus-5274	109	11	's	's	PART
finefocus-5274	109	12	chain	chain	NOUN
finefocus-5274	109	13	termination	termination	NOUN
finefocus-5274	109	14	effects	effect	NOUN
finefocus-5274	109	15	during	during	ADP
finefocus-5274	109	16	dna	dna	PROPN
finefocus-5274	109	17	replication	replication	NOUN
finefocus-5274	109	18	,	,	PUNCT
finefocus-5274	109	19	our	our	PRON
finefocus-5274	109	20	results	result	NOUN
finefocus-5274	109	21	from	from	ADP
finefocus-5274	109	22	limited	limited	ADJ
finefocus-5274	109	23	trials	trial	NOUN
finefocus-5274	109	24	do	do	AUX
finefocus-5274	109	25	not	not	PART
finefocus-5274	109	26	support	support	VERB
finefocus-5274	109	27	this	this	DET
finefocus-5274	109	28	notion	notion	NOUN
finefocus-5274	109	29	.	.	PUNCT
finefocus-5274	110	1	instead	instead	ADV
finefocus-5274	110	2	,	,	PUNCT
finefocus-5274	110	3	it	it	PRON
finefocus-5274	110	4	appears	appear	VERB
finefocus-5274	110	5	that	that	SCONJ
finefocus-5274	110	6	gemcitabine	gemcitabine	NOUN
finefocus-5274	110	7	hydrochloride	hydrochloride	NOUN
finefocus-5274	110	8	may	may	AUX
finefocus-5274	110	9	have	have	VERB
finefocus-5274	110	10	no	no	DET
finefocus-5274	110	11	effect	effect	NOUN
finefocus-5274	110	12	on	on	ADP
finefocus-5274	110	13	tsm	tsm	NOUN
finefocus-5274	110	14	frequency	frequency	NOUN
finefocus-5274	110	15	,	,	PUNCT
finefocus-5274	110	16	aligning	align	VERB
finefocus-5274	110	17	with	with	ADP
finefocus-5274	110	18	its	its	PRON
finefocus-5274	110	19	primary	primary	ADJ
finefocus-5274	110	20	role	role	NOUN
finefocus-5274	110	21	in	in	ADP
finefocus-5274	110	22	inhibiting	inhibit	VERB
finefocus-5274	110	23	dna	dna	ADJ
finefocus-5274	110	24	synthesis	synthesis	NOUN
finefocus-5274	110	25	rather	rather	ADV
finefocus-5274	110	26	than	than	ADP
finefocus-5274	110	27	causing	cause	VERB
finefocus-5274	110	28	replication	replication	NOUN
finefocus-5274	110	29	fork	fork	NOUN
finefocus-5274	110	30	stalling	stall	VERB
finefocus-5274	110	31	26	26	NUM
finefocus-5274	110	32	.	.	PUNCT
finefocus-5274	111	1	similarly	similarly	ADV
finefocus-5274	111	2	,	,	PUNCT
finefocus-5274	111	3	although	although	SCONJ
finefocus-5274	111	4	ibuprofen	ibuprofen	NOUN
finefocus-5274	111	5	's	's	PART
finefocus-5274	111	6	potential	potential	NOUN
finefocus-5274	111	7	to	to	PART
finefocus-5274	111	8	intercalate	intercalate	VERB
finefocus-5274	111	9	within	within	ADP
finefocus-5274	111	10	dna	dna	PROPN
finefocus-5274	111	11	17	17	NUM
finefocus-5274	111	12	could	could	AUX
finefocus-5274	111	13	theoretically	theoretically	ADV
finefocus-5274	111	14	stall	stall	VERB
finefocus-5274	111	15	the	the	DET
finefocus-5274	111	16	replication	replication	NOUN
finefocus-5274	111	17	machinery	machinery	NOUN
finefocus-5274	111	18	,	,	PUNCT
finefocus-5274	111	19	our	our	PRON
finefocus-5274	111	20	trials	trial	NOUN
finefocus-5274	111	21	did	do	AUX
finefocus-5274	111	22	not	not	PART
finefocus-5274	111	23	show	show	VERB
finefocus-5274	111	24	a	a	DET
finefocus-5274	111	25	statistical	statistical	ADJ
finefocus-5274	111	26	increase	increase	NOUN
finefocus-5274	111	27	in	in	ADP
finefocus-5274	111	28	tsm	tsm	NOUN
finefocus-5274	111	29	frequency	frequency	NOUN
finefocus-5274	111	30	.	.	PUNCT
finefocus-5274	112	1	ibuprofen	ibuprofen	PROPN
finefocus-5274	112	2	,	,	PUNCT
finefocus-5274	112	3	hypothesized	hypothesize	VERB
finefocus-5274	112	4	to	to	PART
finefocus-5274	112	5	act	act	VERB
finefocus-5274	112	6	as	as	ADP
finefocus-5274	112	7	an	an	DET
finefocus-5274	112	8	intercalating	intercalate	VERB
finefocus-5274	112	9	agent	agent	NOUN
finefocus-5274	112	10	,	,	PUNCT
finefocus-5274	112	11	likely	likely	ADV
finefocus-5274	112	12	failed	fail	VERB
finefocus-5274	112	13	to	to	PART
finefocus-5274	112	14	intercalate	intercalate	VERB
finefocus-5274	112	15	the	the	DET
finefocus-5274	112	16	dna	dna	NOUN
finefocus-5274	112	17	or	or	CCONJ
finefocus-5274	112	18	caused	cause	VERB
finefocus-5274	112	19	excessive	excessive	ADJ
finefocus-5274	112	20	damage	damage	NOUN
finefocus-5274	112	21	due	due	ADP
finefocus-5274	112	22	to	to	ADP
finefocus-5274	112	23	its	its	PRON
finefocus-5274	112	24	relatively	relatively	ADV
finefocus-5274	112	25	large	large	ADJ
finefocus-5274	112	26	size	size	NOUN
finefocus-5274	112	27	.	.	PUNCT
finefocus-5274	113	1	this	this	PRON
finefocus-5274	113	2	could	could	AUX
finefocus-5274	113	3	explain	explain	VERB
finefocus-5274	113	4	the	the	DET
finefocus-5274	113	5	lack	lack	NOUN
finefocus-5274	113	6	of	of	ADP
finefocus-5274	113	7	change	change	NOUN
finefocus-5274	113	8	in	in	ADP
finefocus-5274	113	9	mutation	mutation	NOUN
finefocus-5274	113	10	frequency	frequency	NOUN
finefocus-5274	113	11	,	,	PUNCT
finefocus-5274	113	12	as	as	SCONJ
finefocus-5274	113	13	the	the	DET
finefocus-5274	113	14	dna	dna	NOUN
finefocus-5274	113	15	either	either	CCONJ
finefocus-5274	113	16	remained	remain	VERB
finefocus-5274	113	17	unchanged	unchanged	ADJ
finefocus-5274	113	18	or	or	CCONJ
finefocus-5274	113	19	was	be	AUX
finefocus-5274	113	20	too	too	ADV
finefocus-5274	113	21	damaged	damage	VERB
finefocus-5274	113	22	to	to	PART
finefocus-5274	113	23	synthesize	synthesize	VERB
finefocus-5274	113	24	properly	properly	ADV
finefocus-5274	113	25	.	.	PUNCT
finefocus-5274	114	1	both	both	PRON
finefocus-5274	114	2	dexamethasone	dexamethasone	NOUN
finefocus-5274	114	3	and	and	CCONJ
finefocus-5274	114	4	doxorubicin	doxorubicin	PROPN
finefocus-5274	114	5	hydrochloride	hydrochloride	NOUN
finefocus-5274	114	6	did	do	AUX
finefocus-5274	114	7	not	not	PART
finefocus-5274	114	8	result	result	VERB
finefocus-5274	114	9	in	in	ADP
finefocus-5274	114	10	a	a	DET
finefocus-5274	114	11	statistically	statistically	ADV
finefocus-5274	114	12	significant	significant	ADJ
finefocus-5274	114	13	change	change	NOUN
finefocus-5274	114	14	in	in	ADP
finefocus-5274	114	15	tsm	tsm	NOUN
finefocus-5274	114	16	rate	rate	NOUN
finefocus-5274	114	17	when	when	SCONJ
finefocus-5274	114	18	compared	compare	VERB
finefocus-5274	114	19	to	to	ADP
finefocus-5274	114	20	the	the	DET
finefocus-5274	114	21	control	control	NOUN
finefocus-5274	114	22	group	group	NOUN
finefocus-5274	114	23	.	.	PUNCT
finefocus-5274	115	1	dexamethasone	dexamethasone	NOUN
finefocus-5274	115	2	and	and	CCONJ
finefocus-5274	115	3	doxorubicin	doxorubicin	PROPN
finefocus-5274	115	4	hydrochloride	hydrochloride	NOUN
finefocus-5274	115	5	,	,	PUNCT
finefocus-5274	115	6	also	also	ADV
finefocus-5274	115	7	predicted	predict	VERB
finefocus-5274	115	8	to	to	PART
finefocus-5274	115	9	intercalate	intercalate	VERB
finefocus-5274	115	10	dna	dna	NOUN
finefocus-5274	115	11	and	and	CCONJ
finefocus-5274	115	12	stall	stall	VERB
finefocus-5274	115	13	the	the	DET
finefocus-5274	115	14	replication	replication	NOUN
finefocus-5274	115	15	fork	fork	NOUN
finefocus-5274	115	16	,	,	PUNCT
finefocus-5274	115	17	may	may	AUX
finefocus-5274	115	18	have	have	AUX
finefocus-5274	115	19	caused	cause	VERB
finefocus-5274	115	20	enough	enough	ADJ
finefocus-5274	115	21	damage	damage	NOUN
finefocus-5274	115	22	to	to	PART
finefocus-5274	115	23	prevent	prevent	VERB
finefocus-5274	115	24	successful	successful	ADJ
finefocus-5274	115	25	replication	replication	NOUN
finefocus-5274	115	26	,	,	PUNCT
finefocus-5274	115	27	leading	lead	VERB
finefocus-5274	115	28	to	to	ADP
finefocus-5274	115	29	no	no	DET
finefocus-5274	115	30	observed	observed	ADJ
finefocus-5274	115	31	change	change	NOUN
finefocus-5274	115	32	in	in	ADP
finefocus-5274	115	33	tsm	tsm	NOUN
finefocus-5274	115	34	frequency	frequency	NOUN
finefocus-5274	115	35	,	,	PUNCT
finefocus-5274	115	36	though	though	SCONJ
finefocus-5274	115	37	additional	additional	ADJ
finefocus-5274	115	38	trials	trial	NOUN
finefocus-5274	115	39	may	may	AUX
finefocus-5274	115	40	provide	provide	VERB
finefocus-5274	115	41	further	further	ADJ
finefocus-5274	115	42	insights	insight	NOUN
finefocus-5274	115	43	.	.	PUNCT
finefocus-5274	116	1	in	in	ADP
finefocus-5274	116	2	contrast	contrast	NOUN
finefocus-5274	116	3	,	,	PUNCT
finefocus-5274	116	4	cpt-11	cpt-11	PROPN
finefocus-5274	116	5	showed	show	VERB
finefocus-5274	116	6	a	a	DET
finefocus-5274	116	7	statistically	statistically	ADV
finefocus-5274	116	8	significant	significant	ADJ
finefocus-5274	116	9	decrease	decrease	NOUN
finefocus-5274	116	10	in	in	ADP
finefocus-5274	116	11	tsm	tsm	NOUN
finefocus-5274	116	12	frequency	frequency	NOUN
finefocus-5274	116	13	.	.	PUNCT
finefocus-5274	117	1	this	this	PRON
finefocus-5274	117	2	supports	support	VERB
finefocus-5274	117	3	the	the	DET
finefocus-5274	117	4	hypothesis	hypothesis	NOUN
finefocus-5274	117	5	that	that	PRON
finefocus-5274	117	6	cpt-11	cpt-11	PROPN
finefocus-5274	117	7	inhibits	inhibit	VERB
finefocus-5274	117	8	topoisomerase	topoisomerase	NOUN
finefocus-5274	117	9	i	i	PRON
finefocus-5274	117	10	and	and	CCONJ
finefocus-5274	117	11	induces	induce	VERB
finefocus-5274	117	12	dna	dna	PROPN
finefocus-5274	117	13	strand	strand	NOUN
finefocus-5274	117	14	breaks	break	NOUN
finefocus-5274	117	15	.	.	PUNCT
finefocus-5274	118	1	these	these	DET
finefocus-5274	118	2	breaks	break	NOUN
finefocus-5274	118	3	likely	likely	ADV
finefocus-5274	118	4	prevent	prevent	VERB
finefocus-5274	118	5	the	the	DET
finefocus-5274	118	6	displacement	displacement	NOUN
finefocus-5274	118	7	of	of	ADP
finefocus-5274	118	8	the	the	DET
finefocus-5274	118	9	nascent	nascent	ADJ
finefocus-5274	118	10	dna	dna	NOUN
finefocus-5274	118	11	strand	strand	NOUN
finefocus-5274	118	12	and	and	CCONJ
finefocus-5274	118	13	instead	instead	ADV
finefocus-5274	118	14	promote	promote	VERB
finefocus-5274	118	15	dna	dna	PROPN
finefocus-5274	118	16	damage	damage	NOUN
finefocus-5274	118	17	repair	repair	NOUN
finefocus-5274	118	18	through	through	ADP
finefocus-5274	118	19	resection	resection	NOUN
finefocus-5274	118	20	and	and	CCONJ
finefocus-5274	118	21	homology	homology	NOUN
finefocus-5274	118	22	search	search	NOUN
finefocus-5274	118	23	rather	rather	ADV
finefocus-5274	118	24	than	than	ADP
finefocus-5274	118	25	quasi	quasi	ADJ
finefocus-5274	118	26	-	-	ADJ
finefocus-5274	118	27	palindrome	palindrome	ADJ
finefocus-5274	118	28	hairpin	hairpin	ADJ
finefocus-5274	118	29	formation	formation	NOUN
finefocus-5274	118	30	,	,	PUNCT
finefocus-5274	118	31	thereby	thereby	ADV
finefocus-5274	118	32	reducing	reduce	VERB
finefocus-5274	118	33	polymerase	polymerase	NOUN
finefocus-5274	118	34	displacement	displacement	NOUN
finefocus-5274	118	35	onto	onto	ADP
finefocus-5274	118	36	the	the	DET
finefocus-5274	118	37	opposite	opposite	ADJ
finefocus-5274	118	38	strand	strand	NOUN
finefocus-5274	118	39	.	.	PUNCT
finefocus-5274	119	1	this	this	PRON
finefocus-5274	119	2	highlights	highlight	VERB
finefocus-5274	119	3	its	its	PRON
finefocus-5274	119	4	potential	potential	ADJ
finefocus-5274	119	5	role	role	NOUN
finefocus-5274	119	6	in	in	ADP
finefocus-5274	119	7	mitigating	mitigate	VERB
finefocus-5274	119	8	tsm	tsm	NOUN
finefocus-5274	119	9	occurrence	occurrence	NOUN
finefocus-5274	119	10	.	.	PUNCT
finefocus-5274	120	1	we	we	PRON
finefocus-5274	120	2	plan	plan	VERB
finefocus-5274	120	3	to	to	PART
finefocus-5274	120	4	further	far	ADV
finefocus-5274	120	5	explore	explore	VERB
finefocus-5274	120	6	the	the	DET
finefocus-5274	120	7	potential	potential	ADJ
finefocus-5274	120	8	impact	impact	NOUN
finefocus-5274	120	9	of	of	ADP
finefocus-5274	120	10	fda	fda	PROPN
finefocus-5274	120	11	-	-	PUNCT
finefocus-5274	120	12	approved	approve	VERB
finefocus-5274	120	13	drugs	drug	NOUN
finefocus-5274	120	14	on	on	ADP
finefocus-5274	120	15	tsm	tsm	NOUN
finefocus-5274	120	16	using	use	VERB
finefocus-5274	120	17	our	our	PRON
finefocus-5274	120	18	extensive	extensive	ADJ
finefocus-5274	120	19	fda	fda	PROPN
finefocus-5274	120	20	-	-	PUNCT
finefocus-5274	120	21	approved	approve	VERB
finefocus-5274	120	22	drug	drug	NOUN
finefocus-5274	120	23	library	library	NOUN
finefocus-5274	120	24	.	.	PUNCT
finefocus-5274	121	1	this	this	DET
finefocus-5274	121	2	ongoing	ongoing	ADJ
finefocus-5274	121	3	investigation	investigation	NOUN
finefocus-5274	121	4	aims	aim	VERB
finefocus-5274	121	5	to	to	PART
finefocus-5274	121	6	investigate	investigate	VERB
finefocus-5274	121	7	on	on	ADP
finefocus-5274	121	8	the	the	DET
finefocus-5274	121	9	mechanisms	mechanism	NOUN
finefocus-5274	121	10	underlying	underlie	VERB
finefocus-5274	121	11	tsm	tsm	NOUN
finefocus-5274	121	12	,	,	PUNCT
finefocus-5274	121	13	including	include	VERB
finefocus-5274	121	14	both	both	CCONJ
finefocus-5274	121	15	natural	natural	ADJ
finefocus-5274	121	16	occurrences	occurrence	NOUN
finefocus-5274	121	17	and	and	CCONJ
finefocus-5274	121	18	drug	drug	NOUN
finefocus-5274	121	19	-	-	PUNCT
finefocus-5274	121	20	induced	induce	VERB
finefocus-5274	121	21	cases	case	NOUN
finefocus-5274	121	22	.	.	PUNCT
finefocus-5274	122	1	additional	additional	ADJ
finefocus-5274	122	2	research	research	NOUN
finefocus-5274	122	3	on	on	ADP
finefocus-5274	122	4	the	the	DET
finefocus-5274	122	5	impact	impact	NOUN
finefocus-5274	122	6	of	of	ADP
finefocus-5274	122	7	drug	drug	NOUN
finefocus-5274	122	8	exposure	exposure	NOUN
finefocus-5274	122	9	on	on	ADP
finefocus-5274	122	10	tsm	tsm	NOUN
finefocus-5274	122	11	should	should	AUX
finefocus-5274	122	12	be	be	AUX
finefocus-5274	122	13	conducted	conduct	VERB
finefocus-5274	122	14	in	in	ADP
finefocus-5274	122	15	mammalian	mammalian	ADJ
finefocus-5274	122	16	cells	cell	NOUN
finefocus-5274	122	17	.	.	PUNCT
finefocus-5274	123	1	while	while	SCONJ
finefocus-5274	123	2	this	this	DET
finefocus-5274	123	3	experiment	experiment	NOUN
finefocus-5274	123	4	focused	focus	VERB
finefocus-5274	123	5	on	on	ADP
finefocus-5274	123	6	e.	e.	PROPN
finefocus-5274	123	7	coli	coli	PROPN
finefocus-5274	123	8	and	and	CCONJ
finefocus-5274	123	9	provided	provide	VERB
finefocus-5274	123	10	valuable	valuable	ADJ
finefocus-5274	123	11	insights	insight	NOUN
finefocus-5274	123	12	,	,	PUNCT
finefocus-5274	123	13	the	the	DET
finefocus-5274	123	14	effects	effect	NOUN
finefocus-5274	123	15	on	on	ADP
finefocus-5274	123	16	mammalian	mammalian	ADJ
finefocus-5274	123	17	cells	cell	NOUN
finefocus-5274	123	18	remain	remain	VERB
finefocus-5274	123	19	unknown	unknown	ADJ
finefocus-5274	123	20	.	.	PUNCT
finefocus-5274	124	1	testing	test	VERB
finefocus-5274	124	2	these	these	DET
finefocus-5274	124	3	drugs	drug	NOUN
finefocus-5274	124	4	in	in	ADP
finefocus-5274	124	5	mammalian	mammalian	ADJ
finefocus-5274	124	6	cells	cell	NOUN
finefocus-5274	124	7	would	would	AUX
finefocus-5274	124	8	allow	allow	VERB
finefocus-5274	124	9	for	for	ADP
finefocus-5274	124	10	a	a	DET
finefocus-5274	124	11	more	more	ADV
finefocus-5274	124	12	direct	direct	ADJ
finefocus-5274	124	13	evaluation	evaluation	NOUN
finefocus-5274	124	14	of	of	ADP
finefocus-5274	124	15	the	the	DET
finefocus-5274	124	16	conclusions	conclusion	NOUN
finefocus-5274	124	17	drawn	draw	VERB
finefocus-5274	124	18	from	from	ADP
finefocus-5274	124	19	this	this	DET
finefocus-5274	124	20	study	study	NOUN
finefocus-5274	124	21	in	in	ADP
finefocus-5274	124	22	a	a	DET
finefocus-5274	124	23	more	more	ADV
finefocus-5274	124	24	complex	complex	ADJ
finefocus-5274	124	25	system	system	NOUN
finefocus-5274	124	26	.	.	PUNCT
finefocus-5274	125	1	this	this	DET
finefocus-5274	125	2	approach	approach	NOUN
finefocus-5274	125	3	would	would	AUX
finefocus-5274	125	4	also	also	ADV
finefocus-5274	125	5	enable	enable	VERB
finefocus-5274	125	6	observations	observation	NOUN
finefocus-5274	125	7	in	in	ADP
finefocus-5274	125	8	cells	cell	NOUN
finefocus-5274	125	9	that	that	PRON
finefocus-5274	125	10	are	be	AUX
finefocus-5274	125	11	susceptible	susceptible	ADJ
finefocus-5274	125	12	to	to	ADP
finefocus-5274	125	13	tsm	tsm	NOUN
finefocus-5274	125	14	-	-	PUNCT
finefocus-5274	125	15	associated	associate	VERB
finefocus-5274	125	16	diseases	disease	NOUN
finefocus-5274	125	17	.	.	PUNCT
finefocus-5274	126	1	such	such	ADJ
finefocus-5274	126	2	findings	finding	NOUN
finefocus-5274	126	3	would	would	AUX
finefocus-5274	126	4	be	be	AUX
finefocus-5274	126	5	particularly	particularly	ADV
finefocus-5274	126	6	compelling	compelling	ADJ
finefocus-5274	126	7	given	give	VERB
finefocus-5274	126	8	that	that	SCONJ
finefocus-5274	126	9	the	the	DET
finefocus-5274	126	10	drugs	drug	NOUN
finefocus-5274	126	11	tested	test	VERB
finefocus-5274	126	12	here	here	ADV
finefocus-5274	126	13	are	be	AUX
finefocus-5274	126	14	also	also	ADV
finefocus-5274	126	15	used	use	VERB
finefocus-5274	126	16	to	to	PART
finefocus-5274	126	17	treat	treat	VERB
finefocus-5274	126	18	other	other	ADJ
finefocus-5274	126	19	diseases	disease	NOUN
finefocus-5274	126	20	not	not	PART
finefocus-5274	126	21	directly	directly	ADV
finefocus-5274	126	22	related	relate	VERB
finefocus-5274	126	23	to	to	ADP
finefocus-5274	126	24	tsm	tsm	NOUN
finefocus-5274	126	25	.	.	PUNCT
finefocus-5274	127	1	this	this	PRON
finefocus-5274	127	2	could	could	AUX
finefocus-5274	127	3	open	open	VERB
finefocus-5274	127	4	discussions	discussion	NOUN
finefocus-5274	127	5	about	about	ADP
finefocus-5274	127	6	the	the	DET
finefocus-5274	127	7	potential	potential	ADJ
finefocus-5274	127	8	consequences	consequence	NOUN
finefocus-5274	127	9	of	of	ADP
finefocus-5274	127	10	using	use	VERB
finefocus-5274	127	11	these	these	DET
finefocus-5274	127	12	therapeutics	therapeutic	NOUN
finefocus-5274	127	13	,	,	PUNCT
finefocus-5274	127	14	especially	especially	ADV
finefocus-5274	127	15	regarding	regard	VERB
finefocus-5274	127	16	their	their	PRON
finefocus-5274	127	17	broader	broad	ADJ
finefocus-5274	127	18	impact	impact	NOUN
finefocus-5274	127	19	on	on	ADP
finefocus-5274	127	20	mutation	mutation	NOUN
finefocus-5274	127	21	frequency	frequency	NOUN
finefocus-5274	127	22	.	.	PUNCT
finefocus-5274	128	1	swain	swain	PROPN
finefocus-5274	128	2	et	et	PROPN
finefocus-5274	128	3	al	al	PROPN
finefocus-5274	128	4	.	.	PUNCT
finefocus-5274	129	1	|	|	ADV
finefocus-5274	129	2	analyzing	analyze	VERB
finefocus-5274	129	3	selected	select	VERB
finefocus-5274	129	4	fda	fda	PROPN
finefocus-5274	129	5	approved	approve	VERB
finefocus-5274	129	6	drugs	drug	NOUN
finefocus-5274	129	7	for	for	ADP
finefocus-5274	129	8	effects	effect	NOUN
finefocus-5274	129	9	on	on	ADP
finefocus-5274	129	10	template	template	NOUN
finefocus-5274	129	11	switch	switch	NOUN
finefocus-5274	129	12	mutagenesis	mutagenesis	NOUN
finefocus-5274	129	13	in	in	ADP
finefocus-5274	129	14	e.	e.	PROPN
finefocus-5274	129	15	coli	coli	PROPN
finefocus-5274	129	16	21	21	NUM
finefocus-5274	129	17	references	reference	NOUN
finefocus-5274	129	18	1	1	NUM
finefocus-5274	129	19	.	.	PUNCT
finefocus-5274	130	1	viswanathan	viswanathan	PROPN
finefocus-5274	130	2	,	,	PUNCT
finefocus-5274	130	3	m.	m.	NOUN
finefocus-5274	130	4	,	,	PUNCT
finefocus-5274	130	5	lacirignola	lacirignola	PROPN
finefocus-5274	130	6	,	,	PUNCT
finefocus-5274	130	7	j.	j.	PROPN
finefocus-5274	130	8	j.	j.	PROPN
finefocus-5274	130	9	,	,	PUNCT
finefocus-5274	130	10	hurley	hurley	PROPN
finefocus-5274	130	11	,	,	PUNCT
finefocus-5274	130	12	r.	r.	PROPN
finefocus-5274	130	13	l.	l.	PROPN
finefocus-5274	130	14	,	,	PUNCT
finefocus-5274	130	15	&	&	CCONJ
finefocus-5274	130	16	lovett	lovett	PROPN
finefocus-5274	130	17	,	,	PUNCT
finefocus-5274	130	18	s.	s.	PROPN
finefocus-5274	130	19	t.	t.	PROPN
finefocus-5274	130	20	(	(	PUNCT
finefocus-5274	130	21	2000	2000	NUM
finefocus-5274	130	22	)	)	PUNCT
finefocus-5274	130	23	.	.	PUNCT
finefocus-5274	131	1	a	a	DET
finefocus-5274	131	2	novel	novel	ADJ
finefocus-5274	131	3	mutational	mutational	ADJ
finefocus-5274	131	4	hotspot	hotspot	NOUN
finefocus-5274	131	5	in	in	ADP
finefocus-5274	131	6	a	a	DET
finefocus-5274	131	7	natural	natural	ADJ
finefocus-5274	131	8	quasipalindrome	quasipalindrome	NOUN
finefocus-5274	131	9	in	in	ADP
finefocus-5274	131	10	escherichia	escherichia	NOUN
finefocus-5274	131	11	coli	coli	NOUN
finefocus-5274	131	12	.	.	PUNCT
finefocus-5274	132	1	journal	journal	NOUN
finefocus-5274	132	2	of	of	ADP
finefocus-5274	132	3	molecular	molecular	ADJ
finefocus-5274	132	4	biology	biology	NOUN
finefocus-5274	132	5	,	,	PUNCT
finefocus-5274	132	6	302(3	302(3	NUM
finefocus-5274	132	7	)	)	PUNCT
finefocus-5274	132	8	,	,	PUNCT
finefocus-5274	132	9	553–564	553–564	NUM
finefocus-5274	132	10	.	.	PUNCT
finefocus-5274	133	1	https://doi.org/10.1006/jmbi.2000.4088	https://doi.org/10.1006/jmbi.2000.4088	PROPN
finefocus-5274	133	2	2	2	NUM
finefocus-5274	133	3	.	.	PUNCT
finefocus-5274	133	4	bissler	bissler	PROPN
finefocus-5274	133	5	,	,	PUNCT
finefocus-5274	133	6	j.	j.	PROPN
finefocus-5274	133	7	j.	j.	PROPN
finefocus-5274	133	8	(	(	PUNCT
finefocus-5274	133	9	1998	1998	NUM
finefocus-5274	133	10	)	)	PUNCT
finefocus-5274	133	11	.	.	PUNCT
finefocus-5274	134	1	dna	dna	PROPN
finefocus-5274	134	2	inverted	invert	VERB
finefocus-5274	134	3	repeats	repeat	NOUN
finefocus-5274	134	4	and	and	CCONJ
finefocus-5274	134	5	human	human	ADJ
finefocus-5274	134	6	disease	disease	NOUN
finefocus-5274	134	7	.	.	PUNCT
finefocus-5274	135	1	frontiers	frontier	NOUN
finefocus-5274	135	2	in	in	ADP
finefocus-5274	135	3	bioscience	bioscience	NOUN
finefocus-5274	135	4	,	,	PUNCT
finefocus-5274	135	5	3	3	NUM
finefocus-5274	135	6	,	,	PUNCT
finefocus-5274	135	7	d408	d408	PROPN
finefocus-5274	135	8	-	-	PUNCT
finefocus-5274	135	9	18	18	NUM
finefocus-5274	135	10	.	.	PUNCT
finefocus-5274	136	1	https://doi.org/10.2741/a284	https://doi.org/10.2741/a284	NUM
finefocus-5274	137	1	3	3	X
finefocus-5274	137	2	.	.	PUNCT
finefocus-5274	137	3	bissler	bissler	PROPN
finefocus-5274	137	4	,	,	PUNCT
finefocus-5274	137	5	j.	j.	PROPN
finefocus-5274	137	6	j.	j.	PROPN
finefocus-5274	137	7	,	,	PUNCT
finefocus-5274	137	8	donaldson	donaldson	PROPN
finefocus-5274	137	9	,	,	PUNCT
finefocus-5274	137	10	v.	v.	PROPN
finefocus-5274	137	11	h.	h.	PROPN
finefocus-5274	137	12	,	,	PUNCT
finefocus-5274	137	13	&	&	CCONJ
finefocus-5274	137	14	davis	davis	PROPN
finefocus-5274	137	15	,	,	PUNCT
finefocus-5274	137	16	a.	a.	PROPN
finefocus-5274	137	17	e.	e.	PROPN
finefocus-5274	137	18	(	(	PUNCT
finefocus-5274	137	19	1994	1994	NUM
finefocus-5274	137	20	)	)	PUNCT
finefocus-5274	137	21	.	.	PUNCT
finefocus-5274	138	1	contiguous	contiguous	ADJ
finefocus-5274	138	2	deletion	deletion	NOUN
finefocus-5274	138	3	and	and	CCONJ
finefocus-5274	138	4	duplication	duplication	NOUN
finefocus-5274	138	5	mutations	mutation	NOUN
finefocus-5274	138	6	resulting	result	VERB
finefocus-5274	138	7	in	in	ADP
finefocus-5274	138	8	type	type	NOUN
finefocus-5274	138	9	1	1	NUM
finefocus-5274	138	10	hereditary	hereditary	ADJ
finefocus-5274	138	11	angioneurotic	angioneurotic	ADJ
finefocus-5274	138	12	edema	edema	NOUN
finefocus-5274	138	13	.	.	PUNCT
finefocus-5274	139	1	human	human	ADJ
finefocus-5274	139	2	genetics	genetic	NOUN
finefocus-5274	139	3	,	,	PUNCT
finefocus-5274	139	4	93(3	93(3	NUM
finefocus-5274	139	5	)	)	PUNCT
finefocus-5274	139	6	,	,	PUNCT
finefocus-5274	139	7	265–269	265–269	NUM
finefocus-5274	139	8	.	.	PUNCT
finefocus-5274	140	1	https://doi.org/10.1007/bf00212020	https://doi.org/10.1007/bf00212020	ADP
finefocus-5274	140	2	4	4	X
finefocus-5274	140	3	.	.	PUNCT
finefocus-5274	140	4	bateman	bateman	PROPN
finefocus-5274	140	5	,	,	PUNCT
finefocus-5274	140	6	j.	j.	PROPN
finefocus-5274	140	7	f.	f.	PROPN
finefocus-5274	140	8	,	,	PUNCT
finefocus-5274	140	9	lamande	lamande	PROPN
finefocus-5274	140	10	,	,	PUNCT
finefocus-5274	140	11	s.	s.	PROPN
finefocus-5274	140	12	r.	r.	PROPN
finefocus-5274	140	13	,	,	PUNCT
finefocus-5274	140	14	dahl	dahl	PROPN
finefocus-5274	140	15	,	,	PUNCT
finefocus-5274	140	16	h.	h.	PROPN
finefocus-5274	140	17	h.	h.	PROPN
finefocus-5274	140	18	,	,	PUNCT
finefocus-5274	140	19	chan	chan	PROPN
finefocus-5274	140	20	,	,	PUNCT
finefocus-5274	140	21	d.	d.	PROPN
finefocus-5274	140	22	,	,	PUNCT
finefocus-5274	140	23	mascara	mascara	NOUN
finefocus-5274	140	24	,	,	PUNCT
finefocus-5274	140	25	t.	t.	PROPN
finefocus-5274	140	26	,	,	PUNCT
finefocus-5274	140	27	&	&	CCONJ
finefocus-5274	140	28	cole	cole	PROPN
finefocus-5274	140	29	,	,	PUNCT
finefocus-5274	140	30	w.	w.	PROPN
finefocus-5274	140	31	g.	g.	PROPN
finefocus-5274	140	32	(	(	PUNCT
finefocus-5274	140	33	1989	1989	NUM
finefocus-5274	140	34	)	)	PUNCT
finefocus-5274	140	35	.	.	PUNCT
finefocus-5274	141	1	a	a	DET
finefocus-5274	141	2	frameshift	frameshift	NOUN
finefocus-5274	141	3	mutation	mutation	NOUN
finefocus-5274	141	4	results	result	NOUN
finefocus-5274	141	5	in	in	ADP
finefocus-5274	141	6	a	a	DET
finefocus-5274	141	7	truncated	truncated	ADJ
finefocus-5274	141	8	nonfunctional	nonfunctional	ADJ
finefocus-5274	141	9	carboxyl	carboxyl	NOUN
finefocus-5274	141	10	-	-	PUNCT
finefocus-5274	141	11	terminal	terminal	NOUN
finefocus-5274	141	12	proα1(i	proα1(i	NOUN
finefocus-5274	141	13	)	)	PUNCT
finefocus-5274	141	14	propeptide	propeptide	NOUN
finefocus-5274	141	15	of	of	ADP
finefocus-5274	141	16	type	type	NOUN
finefocus-5274	141	17	i	i	PRON
finefocus-5274	141	18	collagen	collagen	VERB
finefocus-5274	141	19	in	in	ADP
finefocus-5274	141	20	osteogenesis	osteogenesis	NOUN
finefocus-5274	141	21	imperfecta	imperfecta	NOUN
finefocus-5274	141	22	.	.	PUNCT
finefocus-5274	142	1	journal	journal	PROPN
finefocus-5274	142	2	of	of	ADP
finefocus-5274	142	3	biological	biological	ADJ
finefocus-5274	142	4	chemistry	chemistry	NOUN
finefocus-5274	142	5	,	,	PUNCT
finefocus-5274	142	6	264(19	264(19	NUM
finefocus-5274	142	7	)	)	PUNCT
finefocus-5274	142	8	,	,	PUNCT
finefocus-5274	142	9	10960–10964	10960–10964	NUM
finefocus-5274	142	10	.	.	PUNCT
finefocus-5274	143	1	https://doi.org/10.1016/s0021-9258(18)60412-0	https://doi.org/10.1016/s0021-9258(18)60412-0	PROPN
finefocus-5274	143	2	5	5	NUM
finefocus-5274	143	3	.	.	PUNCT
finefocus-5274	143	4	pomponio	pomponio	PROPN
finefocus-5274	143	5	,	,	PUNCT
finefocus-5274	143	6	r.	r.	PROPN
finefocus-5274	143	7	j.	j.	PROPN
finefocus-5274	143	8	,	,	PUNCT
finefocus-5274	143	9	narasimhan	narasimhan	PROPN
finefocus-5274	143	10	,	,	PUNCT
finefocus-5274	143	11	v.	v.	PROPN
finefocus-5274	143	12	,	,	PUNCT
finefocus-5274	143	13	reynolds	reynold	NOUN
finefocus-5274	143	14	,	,	PUNCT
finefocus-5274	143	15	t.	t.	PROPN
finefocus-5274	143	16	r.	r.	PROPN
finefocus-5274	143	17	,	,	PUNCT
finefocus-5274	143	18	buck	buck	NOUN
finefocus-5274	143	19	,	,	PUNCT
finefocus-5274	143	20	g.	g.	PROPN
finefocus-5274	143	21	a.	a.	PROPN
finefocus-5274	143	22	,	,	PUNCT
finefocus-5274	143	23	povirk	povirk	NOUN
finefocus-5274	143	24	,	,	PUNCT
finefocus-5274	143	25	l.	l.	PROPN
finefocus-5274	143	26	f.	f.	PROPN
finefocus-5274	143	27	,	,	PUNCT
finefocus-5274	143	28	&	&	CCONJ
finefocus-5274	143	29	wolf	wolf	PROPN
finefocus-5274	143	30	,	,	PUNCT
finefocus-5274	143	31	b.	b.	PROPN
finefocus-5274	143	32	(	(	PUNCT
finefocus-5274	143	33	1996	1996	NUM
finefocus-5274	143	34	)	)	PUNCT
finefocus-5274	143	35	.	.	PUNCT
finefocus-5274	144	1	deletion	deletion	NOUN
finefocus-5274	144	2	/	/	SYM
finefocus-5274	144	3	insertion	insertion	NOUN
finefocus-5274	144	4	mutation	mutation	NOUN
finefocus-5274	144	5	that	that	PRON
finefocus-5274	144	6	causes	cause	VERB
finefocus-5274	144	7	biotinidase	biotinidase	NOUN
finefocus-5274	144	8	deficiency	deficiency	NOUN
finefocus-5274	144	9	may	may	AUX
finefocus-5274	144	10	result	result	VERB
finefocus-5274	144	11	from	from	ADP
finefocus-5274	144	12	the	the	DET
finefocus-5274	144	13	formation	formation	NOUN
finefocus-5274	144	14	of	of	ADP
finefocus-5274	144	15	a	a	DET
finefocus-5274	144	16	quasipalindromic	quasipalindromic	ADJ
finefocus-5274	144	17	structure	structure	NOUN
finefocus-5274	144	18	.	.	PUNCT
finefocus-5274	145	1	human	human	ADJ
finefocus-5274	145	2	molecular	molecular	ADJ
finefocus-5274	145	3	genetics	genetic	NOUN
finefocus-5274	145	4	,	,	PUNCT
finefocus-5274	145	5	5(10	5(10	NUM
finefocus-5274	145	6	)	)	PUNCT
finefocus-5274	145	7	,	,	PUNCT
finefocus-5274	145	8	1657–1661	1657–1661	NUM
finefocus-5274	145	9	.	.	PUNCT
finefocus-5274	146	1	https://doi.org/10.1093/hmg/5.10.1657	https://doi.org/10.1093/hmg/5.10.1657	PRON
finefocus-5274	146	2	6	6	NUM
finefocus-5274	146	3	.	.	PUNCT
finefocus-5274	147	1	ripley	ripley	PROPN
finefocus-5274	147	2	,	,	PUNCT
finefocus-5274	147	3	l.	l.	PROPN
finefocus-5274	147	4	s.	s.	PROPN
finefocus-5274	147	5	(	(	PUNCT
finefocus-5274	147	6	1982	1982	NUM
finefocus-5274	147	7	)	)	PUNCT
finefocus-5274	147	8	.	.	PUNCT
finefocus-5274	148	1	model	model	NOUN
finefocus-5274	148	2	for	for	ADP
finefocus-5274	148	3	the	the	DET
finefocus-5274	148	4	participation	participation	NOUN
finefocus-5274	148	5	of	of	ADP
finefocus-5274	148	6	quasi	quasi	ADJ
finefocus-5274	148	7	-	-	ADJ
finefocus-5274	148	8	palindromic	palindromic	ADJ
finefocus-5274	148	9	dna	dna	NOUN
finefocus-5274	148	10	sequences	sequence	NOUN
finefocus-5274	148	11	in	in	ADP
finefocus-5274	148	12	frameshift	frameshift	ADJ
finefocus-5274	148	13	mutation	mutation	NOUN
finefocus-5274	148	14	.	.	PUNCT
finefocus-5274	149	1	proceedings	proceeding	NOUN
finefocus-5274	149	2	of	of	ADP
finefocus-5274	149	3	the	the	DET
finefocus-5274	149	4	national	national	PROPN
finefocus-5274	149	5	academy	academy	PROPN
finefocus-5274	149	6	of	of	ADP
finefocus-5274	149	7	sciences	sciences	PROPN
finefocus-5274	149	8	,	,	PUNCT
finefocus-5274	149	9	79(13	79(13	NUM
finefocus-5274	149	10	)	)	PUNCT
finefocus-5274	149	11	,	,	PUNCT
finefocus-5274	149	12	4128–4132	4128–4132	NUM
finefocus-5274	149	13	.	.	PUNCT
finefocus-5274	149	14	https://doi.org/10.1073/pnas.79.13.4128	https://doi.org/10.1073/pnas.79.13.4128	PROPN
finefocus-5274	149	15	7	7	NUM
finefocus-5274	149	16	.	.	PUNCT
finefocus-5274	149	17	rosche	rosche	PROPN
finefocus-5274	149	18	,	,	PUNCT
finefocus-5274	149	19	w.	w.	PROPN
finefocus-5274	149	20	a.	a.	PROPN
finefocus-5274	149	21	,	,	PUNCT
finefocus-5274	149	22	trinh	trinh	PROPN
finefocus-5274	149	23	,	,	PUNCT
finefocus-5274	149	24	t.	t.	PROPN
finefocus-5274	149	25	q.	q.	PROPN
finefocus-5274	149	26	,	,	PUNCT
finefocus-5274	149	27	&	&	CCONJ
finefocus-5274	149	28	sinden	sinden	PROPN
finefocus-5274	149	29	,	,	PUNCT
finefocus-5274	149	30	r.	r.	PROPN
finefocus-5274	149	31	r.	r.	PROPN
finefocus-5274	149	32	(	(	PUNCT
finefocus-5274	149	33	1997	1997	NUM
finefocus-5274	149	34	)	)	PUNCT
finefocus-5274	149	35	.	.	PUNCT
finefocus-5274	150	1	leading	lead	VERB
finefocus-5274	150	2	strand	strand	NUM
finefocus-5274	150	3	specific	specific	ADJ
finefocus-5274	150	4	spontaneous	spontaneous	ADJ
finefocus-5274	150	5	mutation	mutation	NOUN
finefocus-5274	150	6	corrects	correct	VERB
finefocus-5274	150	7	a	a	DET
finefocus-5274	150	8	quasipalindrome	quasipalindrome	NOUN
finefocus-5274	150	9	by	by	ADP
finefocus-5274	150	10	an	an	DET
finefocus-5274	150	11	intermolecular	intermolecular	ADJ
finefocus-5274	150	12	strand	strand	NOUN
finefocus-5274	150	13	switch	switch	NOUN
finefocus-5274	150	14	mechanism1	mechanism1	PROPN
finefocus-5274	150	15	.	.	PUNCT
finefocus-5274	151	1	journal	journal	NOUN
finefocus-5274	151	2	of	of	ADP
finefocus-5274	151	3	molecular	molecular	ADJ
finefocus-5274	151	4	biology	biology	NOUN
finefocus-5274	151	5	,	,	PUNCT
finefocus-5274	151	6	269(2	269(2	NUM
finefocus-5274	151	7	)	)	PUNCT
finefocus-5274	151	8	,	,	PUNCT
finefocus-5274	151	9	176–187	176–187	NUM
finefocus-5274	151	10	.	.	PUNCT
finefocus-5274	152	1	https://doi.org/10.1006/jmbi.1997.1034	https://doi.org/10.1006/jmbi.1997.1034	PROPN
finefocus-5274	152	2	8	8	NUM
finefocus-5274	152	3	.	.	X
finefocus-5274	153	1	seier	seier	NOUN
finefocus-5274	153	2	,	,	PUNCT
finefocus-5274	153	3	t.	t.	PROPN
finefocus-5274	153	4	,	,	PUNCT
finefocus-5274	153	5	padgett	padgett	PROPN
finefocus-5274	153	6	,	,	PUNCT
finefocus-5274	153	7	d.	d.	PROPN
finefocus-5274	153	8	r.	r.	PROPN
finefocus-5274	153	9	,	,	PUNCT
finefocus-5274	153	10	zilberberg	zilberberg	PROPN
finefocus-5274	153	11	,	,	PUNCT
finefocus-5274	153	12	g.	g.	PROPN
finefocus-5274	153	13	,	,	PUNCT
finefocus-5274	153	14	sutera	sutera	NOUN
finefocus-5274	153	15	,	,	PUNCT
finefocus-5274	153	16	v.	v.	PROPN
finefocus-5274	153	17	a.	a.	PROPN
finefocus-5274	153	18	,	,	PUNCT
finefocus-5274	153	19	toha	toha	PROPN
finefocus-5274	153	20	,	,	PUNCT
finefocus-5274	153	21	n.	n.	NOUN
finefocus-5274	153	22	,	,	PUNCT
finefocus-5274	153	23	&	&	CCONJ
finefocus-5274	153	24	lovett	lovett	PROPN
finefocus-5274	153	25	,	,	PUNCT
finefocus-5274	153	26	s.	s.	PROPN
finefocus-5274	153	27	t.	t.	PROPN
finefocus-5274	153	28	(	(	PUNCT
finefocus-5274	153	29	2011	2011	NUM
finefocus-5274	153	30	)	)	PUNCT
finefocus-5274	153	31	.	.	PUNCT
finefocus-5274	154	1	insights	insight	NOUN
finefocus-5274	154	2	into	into	ADP
finefocus-5274	154	3	mutagenesis	mutagenesis	NOUN
finefocus-5274	154	4	using	use	VERB
finefocus-5274	154	5	escherichia	escherichia	NOUN
finefocus-5274	154	6	coli	coli	NOUN
finefocus-5274	154	7	chromosomal	chromosomal	ADJ
finefocus-5274	154	8	lacz	lacz	NOUN
finefocus-5274	154	9	strains	strain	VERB
finefocus-5274	154	10	that	that	PRON
finefocus-5274	154	11	enable	enable	VERB
finefocus-5274	154	12	detection	detection	NOUN
finefocus-5274	154	13	of	of	ADP
finefocus-5274	154	14	a	a	DET
finefocus-5274	154	15	wide	wide	ADJ
finefocus-5274	154	16	spectrum	spectrum	NOUN
finefocus-5274	154	17	of	of	ADP
finefocus-5274	154	18	mutational	mutational	ADJ
finefocus-5274	154	19	events	event	NOUN
finefocus-5274	154	20	.	.	PUNCT
finefocus-5274	155	1	genetics	genetic	NOUN
finefocus-5274	155	2	,	,	PUNCT
finefocus-5274	155	3	188(2	188(2	NUM
finefocus-5274	155	4	)	)	PUNCT
finefocus-5274	155	5	,	,	PUNCT
finefocus-5274	155	6	247–262	247–262	NUM
finefocus-5274	155	7	.	.	PUNCT
finefocus-5274	156	1	https://doi.org/10.1534/	https://doi.org/10.1534/	NOUN
finefocus-5274	156	2	genetics.111.127746	genetics.111.127746	PRON
finefocus-5274	156	3	9	9	NUM
finefocus-5274	156	4	.	.	X
finefocus-5274	156	5	dutra	dutra	PROPN
finefocus-5274	156	6	,	,	PUNCT
finefocus-5274	156	7	b.	b.	PROPN
finefocus-5274	156	8	e.	e.	PROPN
finefocus-5274	156	9	,	,	PUNCT
finefocus-5274	156	10	&	&	CCONJ
finefocus-5274	156	11	lovett	lovett	PROPN
finefocus-5274	156	12	,	,	PUNCT
finefocus-5274	156	13	s.	s.	PROPN
finefocus-5274	156	14	t.	t.	PROPN
finefocus-5274	156	15	(	(	PUNCT
finefocus-5274	156	16	2006	2006	NUM
finefocus-5274	156	17	)	)	PUNCT
finefocus-5274	156	18	.	.	PUNCT
finefocus-5274	157	1	cis	cis	NOUN
finefocus-5274	157	2	and	and	CCONJ
finefocus-5274	157	3	trans	trans	ADJ
finefocus-5274	157	4	-	-	ADJ
finefocus-5274	157	5	acting	acting	ADJ
finefocus-5274	157	6	effects	effect	NOUN
finefocus-5274	157	7	on	on	ADP
finefocus-5274	157	8	a	a	DET
finefocus-5274	157	9	mutational	mutational	ADJ
finefocus-5274	157	10	hotspot	hotspot	NOUN
finefocus-5274	157	11	involving	involve	VERB
finefocus-5274	157	12	a	a	DET
finefocus-5274	157	13	replication	replication	NOUN
finefocus-5274	157	14	template	template	NOUN
finefocus-5274	157	15	switch	switch	NOUN
finefocus-5274	157	16	.	.	PUNCT
finefocus-5274	158	1	journal	journal	NOUN
finefocus-5274	158	2	of	of	ADP
finefocus-5274	158	3	molecular	molecular	ADJ
finefocus-5274	158	4	biology	biology	NOUN
finefocus-5274	158	5	,	,	PUNCT
finefocus-5274	158	6	356(2	356(2	NUM
finefocus-5274	158	7	)	)	PUNCT
finefocus-5274	158	8	,	,	PUNCT
finefocus-5274	158	9	300–311	300–311	NUM
finefocus-5274	158	10	.	.	PUNCT
finefocus-5274	159	1	https://doi.org/10.1016/j.jmb.2005.11.071	https://doi.org/10.1016/j.jmb.2005.11.071	PROPN
finefocus-5274	159	2	10	10	NUM
finefocus-5274	159	3	.	.	PUNCT
finefocus-5274	160	1	laranjo	laranjo	PROPN
finefocus-5274	160	2	,	,	PUNCT
finefocus-5274	160	3	l.	l.	PROPN
finefocus-5274	160	4	t.	t.	PROPN
finefocus-5274	160	5	,	,	PUNCT
finefocus-5274	160	6	klaric	klaric	PROPN
finefocus-5274	160	7	,	,	PUNCT
finefocus-5274	160	8	j.	j.	PROPN
finefocus-5274	160	9	a.	a.	PROPN
finefocus-5274	160	10	,	,	PUNCT
finefocus-5274	160	11	pearlman	pearlman	PROPN
finefocus-5274	160	12	,	,	PUNCT
finefocus-5274	160	13	l.	l.	PROPN
finefocus-5274	160	14	r.	r.	PROPN
finefocus-5274	160	15	,	,	PUNCT
finefocus-5274	160	16	&	&	CCONJ
finefocus-5274	160	17	lovett	lovett	PROPN
finefocus-5274	160	18	,	,	PUNCT
finefocus-5274	160	19	s.	s.	PROPN
finefocus-5274	160	20	t.	t.	PROPN
finefocus-5274	160	21	(	(	PUNCT
finefocus-5274	160	22	2018	2018	NUM
finefocus-5274	160	23	)	)	PUNCT
finefocus-5274	160	24	.	.	PUNCT
finefocus-5274	161	1	stimulation	stimulation	NOUN
finefocus-5274	161	2	of	of	ADP
finefocus-5274	161	3	replication	replication	NOUN
finefocus-5274	161	4	template	template	NOUN
finefocus-5274	161	5	-	-	PUNCT
finefocus-5274	161	6	switching	switching	NOUN
finefocus-5274	161	7	by	by	ADP
finefocus-5274	161	8	dna	dna	NOUN
finefocus-5274	161	9	-	-	PUNCT
finefocus-5274	161	10	protein	protein	NOUN
finefocus-5274	161	11	crosslinks	crosslink	NOUN
finefocus-5274	161	12	.	.	PUNCT
finefocus-5274	162	1	genes	gene	NOUN
finefocus-5274	162	2	,	,	PUNCT
finefocus-5274	162	3	10(1	10(1	NUM
finefocus-5274	162	4	)	)	PUNCT
finefocus-5274	162	5	,	,	PUNCT
finefocus-5274	162	6	14	14	NUM
finefocus-5274	162	7	.	.	PUNCT
finefocus-5274	162	8	https://doi.org/10.3390/genes10010014	https://doi.org/10.3390/genes10010014	PROPN
finefocus-5274	162	9	11	11	NUM
finefocus-5274	162	10	.	.	PUNCT
finefocus-5274	163	1	seier	seier	NOUN
finefocus-5274	163	2	,	,	PUNCT
finefocus-5274	163	3	t.	t.	PROPN
finefocus-5274	163	4	,	,	PUNCT
finefocus-5274	163	5	zilberberg	zilberberg	PROPN
finefocus-5274	163	6	,	,	PUNCT
finefocus-5274	163	7	g.	g.	NOUN
finefocus-5274	163	8	,	,	PUNCT
finefocus-5274	163	9	zeiger	zeiger	NOUN
finefocus-5274	163	10	,	,	PUNCT
finefocus-5274	163	11	d.	d.	PROPN
finefocus-5274	163	12	m.	m.	PROPN
finefocus-5274	163	13	,	,	PUNCT
finefocus-5274	163	14	&	&	CCONJ
finefocus-5274	163	15	lovett	lovett	PROPN
finefocus-5274	163	16	,	,	PUNCT
finefocus-5274	163	17	s.	s.	PROPN
finefocus-5274	163	18	t.	t.	PROPN
finefocus-5274	163	19	(	(	PUNCT
finefocus-5274	163	20	2012	2012	NUM
finefocus-5274	163	21	)	)	PUNCT
finefocus-5274	163	22	.	.	PUNCT
finefocus-5274	164	1	azidothymidine	azidothymidine	NOUN
finefocus-5274	164	2	and	and	CCONJ
finefocus-5274	164	3	other	other	ADJ
finefocus-5274	164	4	chain	chain	NOUN
finefocus-5274	164	5	terminators	terminator	NOUN
finefocus-5274	164	6	are	be	AUX
finefocus-5274	164	7	mutagenic	mutagenic	ADJ
finefocus-5274	164	8	for	for	ADP
finefocus-5274	164	9	template	template	NOUN
finefocus-5274	164	10	-	-	PUNCT
finefocus-5274	164	11	switch	switch	NOUN
finefocus-5274	164	12	-	-	PUNCT
finefocus-5274	164	13	generated	generate	VERB
finefocus-5274	164	14	genetic	genetic	ADJ
finefocus-5274	164	15	mutations	mutation	NOUN
finefocus-5274	164	16	.	.	PUNCT
finefocus-5274	165	1	proceedings	proceeding	NOUN
finefocus-5274	165	2	of	of	ADP
finefocus-5274	165	3	the	the	DET
finefocus-5274	165	4	national	national	PROPN
finefocus-5274	165	5	academy	academy	PROPN
finefocus-5274	165	6	of	of	ADP
finefocus-5274	165	7	sciences	sciences	PROPN
finefocus-5274	165	8	,	,	PUNCT
finefocus-5274	165	9	109(16	109(16	NUM
finefocus-5274	165	10	)	)	PUNCT
finefocus-5274	165	11	,	,	PUNCT
finefocus-5274	165	12	6171–6174	6171–6174	NUM
finefocus-5274	165	13	.	.	PUNCT
finefocus-5274	166	1	https://doi.org/10.1073/pnas.1116160109	https://doi.org/10.1073/pnas.1116160109	ADJ
finefocus-5274	166	2	12	12	NUM
finefocus-5274	166	3	.	.	PUNCT
finefocus-5274	167	1	santi	santi	PROPN
finefocus-5274	167	2	,	,	PUNCT
finefocus-5274	167	3	d.	d.	PROPN
finefocus-5274	167	4	v.	v.	PROPN
finefocus-5274	167	5	,	,	PUNCT
finefocus-5274	167	6	norment	norment	NOUN
finefocus-5274	167	7	,	,	PUNCT
finefocus-5274	167	8	a.	a.	PROPN
finefocus-5274	167	9	,	,	PUNCT
finefocus-5274	167	10	&	&	CCONJ
finefocus-5274	167	11	garrett	garrett	PROPN
finefocus-5274	167	12	,	,	PUNCT
finefocus-5274	167	13	c.	c.	PROPN
finefocus-5274	167	14	e.	e.	PROPN
finefocus-5274	167	15	(	(	PUNCT
finefocus-5274	167	16	1984	1984	NUM
finefocus-5274	167	17	)	)	PUNCT
finefocus-5274	167	18	.	.	PUNCT
finefocus-5274	168	1	covalent	covalent	ADJ
finefocus-5274	168	2	bond	bond	NOUN
finefocus-5274	168	3	formation	formation	NOUN
finefocus-5274	168	4	between	between	ADP
finefocus-5274	168	5	a	a	DET
finefocus-5274	168	6	dna	dna	NOUN
finefocus-5274	168	7	-	-	PUNCT
finefocus-5274	168	8	cytosine	cytosine	NOUN
finefocus-5274	168	9	methyltransferase	methyltransferase	NOUN
finefocus-5274	168	10	and	and	CCONJ
finefocus-5274	168	11	dna	dna	NOUN
finefocus-5274	168	12	containing	contain	VERB
finefocus-5274	168	13	5	5	NUM
finefocus-5274	168	14	-	-	PUNCT
finefocus-5274	168	15	azacytosine	azacytosine	NOUN
finefocus-5274	168	16	.	.	PUNCT
finefocus-5274	169	1	proceedings	proceeding	NOUN
finefocus-5274	169	2	of	of	ADP
finefocus-5274	169	3	the	the	DET
finefocus-5274	169	4	national	national	PROPN
finefocus-5274	169	5	academy	academy	PROPN
finefocus-5274	169	6	of	of	ADP
finefocus-5274	169	7	sciences	sciences	PROPN
finefocus-5274	169	8	,	,	PUNCT
finefocus-5274	169	9	81(22	81(22	NUM
finefocus-5274	169	10	)	)	PUNCT
finefocus-5274	169	11	,	,	PUNCT
finefocus-5274	169	12	6993–6997	6993–6997	NOUN
finefocus-5274	169	13	.	.	PUNCT
finefocus-5274	170	1	https://doi.org/10.1073/pnas.81.22.6993	https://doi.org/10.1073/pnas.81.22.6993	PROPN
finefocus-5274	170	2	https://doi.org/10.1006/jmbi.2000.4088	https://doi.org/10.1006/jmbi.2000.4088	PROPN
finefocus-5274	170	3	https://doi.org/10.2741/a284	https://doi.org/10.2741/a284	PROPN
finefocus-5274	171	1	https://doi.org/10.1007/bf00212020	https://doi.org/10.1007/bf00212020	PRON
finefocus-5274	171	2	https://doi.org/10.1016/s0021-9258(18)60412-0	https://doi.org/10.1016/s0021-9258(18)60412-0	VERB
finefocus-5274	171	3	https://doi.org/10.1093/hmg/5.10.1657	https://doi.org/10.1093/hmg/5.10.1657	NUM
finefocus-5274	171	4	https://doi.org/10.1073/pnas.79.13.4128	https://doi.org/10.1073/pnas.79.13.4128	X
finefocus-5274	171	5	https://doi.org/10.1006/jmbi.1997.1034	https://doi.org/10.1006/jmbi.1997.1034	PUNCT
finefocus-5274	171	6	https://doi.org/10.1534/genetics.111.127746	https://doi.org/10.1534/genetics.111.127746	PRON
finefocus-5274	171	7	https://doi.org/10.1534/genetics.111.127746	https://doi.org/10.1534/genetics.111.127746	PROPN
finefocus-5274	171	8	https://doi.org/10.1016/j.jmb.2005.11.071	https://doi.org/10.1016/j.jmb.2005.11.071	NOUN
finefocus-5274	171	9	https://doi.org/10.3390/genes10010014	https://doi.org/10.3390/genes10010014	PROPN
finefocus-5274	171	10	https://doi.org/10.1073/pnas.1116160109	https://doi.org/10.1073/pnas.1116160109	VERB
finefocus-5274	171	11	https://doi.org/10.1073/pnas.81.22.6993	https://doi.org/10.1073/pnas.81.22.6993	X
finefocus-5274	171	12	fine	fine	ADJ
finefocus-5274	171	13	focus	focus	NOUN
finefocus-5274	171	14	|	|	ADV
finefocus-5274	171	15	volume	volume	VERB
finefocus-5274	171	16	1122	1122	NUM
finefocus-5274	171	17	13	13	NUM
finefocus-5274	171	18	.	.	PUNCT
finefocus-5274	172	1	kuo	kuo	PROPN
finefocus-5274	172	2	,	,	PUNCT
finefocus-5274	172	3	h.	h.	PROPN
finefocus-5274	172	4	k.	k.	PROPN
finefocus-5274	172	5	,	,	PUNCT
finefocus-5274	172	6	griffith	griffith	PROPN
finefocus-5274	172	7	,	,	PUNCT
finefocus-5274	172	8	j.	j.	PROPN
finefocus-5274	172	9	d.	d.	PROPN
finefocus-5274	172	10	,	,	PUNCT
finefocus-5274	172	11	&	&	CCONJ
finefocus-5274	172	12	kreuzer	kreuzer	PROPN
finefocus-5274	172	13	,	,	PUNCT
finefocus-5274	172	14	k.	k.	PROPN
finefocus-5274	172	15	n.	n.	PROPN
finefocus-5274	172	16	(	(	PUNCT
finefocus-5274	172	17	2007	2007	NUM
finefocus-5274	172	18	)	)	PUNCT
finefocus-5274	172	19	.	.	PUNCT
finefocus-5274	173	1	5	5	NUM
finefocus-5274	173	2	-	-	PUNCT
finefocus-5274	173	3	azacytidine	azacytidine	NOUN
finefocus-5274	173	4	–	–	PUNCT
finefocus-5274	173	5	induced	induce	VERB
finefocus-5274	173	6	methyltransferase	methyltransferase	NOUN
finefocus-5274	173	7	-	-	PUNCT
finefocus-5274	173	8	dna	dna	NOUN
finefocus-5274	173	9	adducts	adduct	VERB
finefocus-5274	173	10	block	block	NOUN
finefocus-5274	173	11	dna	dna	NOUN
finefocus-5274	173	12	replication	replication	NOUN
finefocus-5274	173	13	in	in	ADP
finefocus-5274	173	14	vivo	vivo	NOUN
finefocus-5274	173	15	.	.	PUNCT
finefocus-5274	174	1	cancer	cancer	NOUN
finefocus-5274	174	2	research	research	NOUN
finefocus-5274	174	3	,	,	PUNCT
finefocus-5274	174	4	67(17	67(17	NUM
finefocus-5274	174	5	)	)	PUNCT
finefocus-5274	174	6	,	,	PUNCT
finefocus-5274	174	7	8248–8254	8248–8254	NUM
finefocus-5274	174	8	.	.	PUNCT
finefocus-5274	175	1	https://doi.org/10.1158/0008-5472.can-07-1038	https://doi.org/10.1158/0008-5472.can-07-1038	PROPN
finefocus-5274	175	2	14	14	NUM
finefocus-5274	175	3	.	.	PUNCT
finefocus-5274	176	1	sreedharan	sreedharan	PROPN
finefocus-5274	176	2	,	,	PUNCT
finefocus-5274	176	3	s.	s.	PROPN
finefocus-5274	176	4	,	,	PUNCT
finefocus-5274	176	5	oram	oram	PROPN
finefocus-5274	176	6	,	,	PUNCT
finefocus-5274	176	7	m.	m.	NOUN
finefocus-5274	176	8	,	,	PUNCT
finefocus-5274	176	9	jensen	jensen	PROPN
finefocus-5274	176	10	,	,	PUNCT
finefocus-5274	176	11	b.	b.	PROPN
finefocus-5274	176	12	,	,	PUNCT
finefocus-5274	176	13	peterson	peterson	PROPN
finefocus-5274	176	14	,	,	PUNCT
finefocus-5274	176	15	l.	l.	PROPN
finefocus-5274	176	16	r.	r.	PROPN
finefocus-5274	176	17	,	,	PUNCT
finefocus-5274	176	18	&	&	CCONJ
finefocus-5274	176	19	fisher	fisher	PROPN
finefocus-5274	176	20	,	,	PUNCT
finefocus-5274	176	21	l.	l.	PROPN
finefocus-5274	176	22	m.	m.	PROPN
finefocus-5274	176	23	(	(	PUNCT
finefocus-5274	176	24	1990	1990	NUM
finefocus-5274	176	25	)	)	PUNCT
finefocus-5274	176	26	.	.	PUNCT
finefocus-5274	177	1	dna	dna	PROPN
finefocus-5274	177	2	gyrase	gyrase	NOUN
finefocus-5274	177	3	gyra	gyra	NOUN
finefocus-5274	177	4	mutations	mutation	NOUN
finefocus-5274	177	5	in	in	ADP
finefocus-5274	177	6	ciprofloxacin	ciprofloxacin	NOUN
finefocus-5274	177	7	-	-	PUNCT
finefocus-5274	177	8	resistant	resistant	ADJ
finefocus-5274	177	9	strains	strain	NOUN
finefocus-5274	177	10	of	of	ADP
finefocus-5274	177	11	staphylococcus	staphylococcus	NOUN
finefocus-5274	177	12	aureus	aureus	NOUN
finefocus-5274	177	13	:	:	PUNCT
finefocus-5274	177	14	close	close	ADJ
finefocus-5274	177	15	similarity	similarity	NOUN
finefocus-5274	177	16	with	with	ADP
finefocus-5274	177	17	quinolone	quinolone	ADJ
finefocus-5274	177	18	resistance	resistance	NOUN
finefocus-5274	177	19	mutations	mutation	NOUN
finefocus-5274	177	20	in	in	ADP
finefocus-5274	177	21	escherichia	escherichia	NOUN
finefocus-5274	177	22	coli	coli	NOUN
finefocus-5274	177	23	.	.	PUNCT
finefocus-5274	178	1	journal	journal	PROPN
finefocus-5274	178	2	of	of	ADP
finefocus-5274	178	3	bacteriology	bacteriology	NOUN
finefocus-5274	178	4	,	,	PUNCT
finefocus-5274	178	5	172(12	172(12	NUM
finefocus-5274	178	6	)	)	PUNCT
finefocus-5274	178	7	,	,	PUNCT
finefocus-5274	178	8	7260–7262	7260–7262	NUM
finefocus-5274	178	9	.	.	PUNCT
finefocus-5274	179	1	https://doi.org/10.1128/jb.172.12.7260-7262.1990	https://doi.org/10.1128/jb.172.12.7260-7262.1990	ADP
finefocus-5274	179	2	15	15	NUM
finefocus-5274	179	3	.	.	PUNCT
finefocus-5274	180	1	craft	craft	NOUN
finefocus-5274	180	2	,	,	PUNCT
finefocus-5274	180	3	t.	t.	PROPN
finefocus-5274	180	4	r.	r.	PROPN
finefocus-5274	180	5	,	,	PUNCT
finefocus-5274	180	6	bermudez	bermudez	PROPN
finefocus-5274	180	7	,	,	PUNCT
finefocus-5274	180	8	e.	e.	PROPN
finefocus-5274	180	9	,	,	PUNCT
finefocus-5274	180	10	&	&	CCONJ
finefocus-5274	180	11	skopek	skopek	PROPN
finefocus-5274	180	12	,	,	PUNCT
finefocus-5274	180	13	t.	t.	PROPN
finefocus-5274	180	14	r.	r.	PROPN
finefocus-5274	180	15	(	(	PUNCT
finefocus-5274	180	16	1987	1987	NUM
finefocus-5274	180	17	)	)	PUNCT
finefocus-5274	180	18	.	.	PUNCT
finefocus-5274	181	1	formaldehyde	formaldehyde	NOUN
finefocus-5274	181	2	mutagenesis	mutagenesis	NOUN
finefocus-5274	181	3	and	and	CCONJ
finefocus-5274	181	4	formation	formation	NOUN
finefocus-5274	181	5	of	of	ADP
finefocus-5274	181	6	dna	dna	NOUN
finefocus-5274	181	7	-	-	PUNCT
finefocus-5274	181	8	protein	protein	NOUN
finefocus-5274	181	9	crosslinks	crosslink	NOUN
finefocus-5274	181	10	in	in	ADP
finefocus-5274	181	11	human	human	ADJ
finefocus-5274	181	12	lymphoblasts	lymphoblast	NOUN
finefocus-5274	181	13	in	in	ADP
finefocus-5274	181	14	vitro	vitro	X
finefocus-5274	181	15	.	.	PUNCT
finefocus-5274	182	1	mutation	mutation	NOUN
finefocus-5274	182	2	research	research	NOUN
finefocus-5274	182	3	/	/	SYM
finefocus-5274	182	4	fundamental	fundamental	ADJ
finefocus-5274	182	5	and	and	CCONJ
finefocus-5274	182	6	molecular	molecular	ADJ
finefocus-5274	182	7	mechanisms	mechanism	NOUN
finefocus-5274	182	8	of	of	ADP
finefocus-5274	182	9	mutagenesis	mutagenesis	NOUN
finefocus-5274	182	10	,	,	PUNCT
finefocus-5274	182	11	176(1	176(1	NUM
finefocus-5274	182	12	)	)	PUNCT
finefocus-5274	182	13	,	,	PUNCT
finefocus-5274	182	14	147–155	147–155	NUM
finefocus-5274	182	15	.	.	PUNCT
finefocus-5274	183	1	https://doi.org/10.1016/0027-5107(87)90262-4	https://doi.org/10.1016/0027-5107(87)90262-4	PROPN
finefocus-5274	183	2	16	16	NUM
finefocus-5274	183	3	.	.	PUNCT
finefocus-5274	184	1	heinemann	heinemann	PROPN
finefocus-5274	184	2	,	,	PUNCT
finefocus-5274	184	3	v.	v.	ADV
finefocus-5274	184	4	,	,	PUNCT
finefocus-5274	184	5	hertel	hertel	PROPN
finefocus-5274	184	6	,	,	PUNCT
finefocus-5274	184	7	l.	l.	PROPN
finefocus-5274	184	8	w.	w.	PROPN
finefocus-5274	184	9	,	,	PUNCT
finefocus-5274	184	10	grindey	grindey	PROPN
finefocus-5274	184	11	,	,	PUNCT
finefocus-5274	184	12	g.	g.	PROPN
finefocus-5274	184	13	b.	b.	PROPN
finefocus-5274	184	14	,	,	PUNCT
finefocus-5274	184	15	&	&	CCONJ
finefocus-5274	184	16	plunkett	plunkett	PROPN
finefocus-5274	184	17	,	,	PUNCT
finefocus-5274	184	18	w.	w.	PROPN
finefocus-5274	184	19	(	(	PUNCT
finefocus-5274	184	20	1988	1988	NUM
finefocus-5274	184	21	)	)	PUNCT
finefocus-5274	184	22	.	.	PUNCT
finefocus-5274	185	1	comparison	comparison	NOUN
finefocus-5274	185	2	of	of	ADP
finefocus-5274	185	3	the	the	DET
finefocus-5274	185	4	cellular	cellular	ADJ
finefocus-5274	185	5	pharmacokinetics	pharmacokinetic	NOUN
finefocus-5274	185	6	and	and	CCONJ
finefocus-5274	185	7	toxicity	toxicity	NOUN
finefocus-5274	185	8	of	of	ADP
finefocus-5274	185	9	2’,2’-difluorodeoxycytidine	2’,2’-difluorodeoxycytidine	NUM
finefocus-5274	185	10	and	and	CCONJ
finefocus-5274	185	11	1	1	NUM
finefocus-5274	185	12	-	-	PUNCT
finefocus-5274	185	13	beta	beta	NOUN
finefocus-5274	185	14	-	-	PUNCT
finefocus-5274	185	15	d	d	NOUN
finefocus-5274	185	16	-	-	NOUN
finefocus-5274	185	17	arabinofuranosylcytosine	arabinofuranosylcytosine	NOUN
finefocus-5274	185	18	.	.	PUNCT
finefocus-5274	186	1	cancer	cancer	NOUN
finefocus-5274	186	2	research	research	NOUN
finefocus-5274	186	3	,	,	PUNCT
finefocus-5274	186	4	48(14	48(14	NOUN
finefocus-5274	186	5	)	)	PUNCT
finefocus-5274	186	6	,	,	PUNCT
finefocus-5274	186	7	4024–4031	4024–4031	NUM
finefocus-5274	186	8	.	.	PUNCT
finefocus-5274	187	1	17	17	NUM
finefocus-5274	187	2	.	.	PUNCT
finefocus-5274	188	1	husain	husain	PROPN
finefocus-5274	188	2	,	,	PUNCT
finefocus-5274	188	3	m.	m.	NOUN
finefocus-5274	188	4	a.	a.	PROPN
finefocus-5274	188	5	,	,	PUNCT
finefocus-5274	188	6	sarwar	sarwar	PROPN
finefocus-5274	188	7	,	,	PUNCT
finefocus-5274	188	8	t.	t.	PROPN
finefocus-5274	188	9	,	,	PUNCT
finefocus-5274	188	10	rehman	rehman	PROPN
finefocus-5274	188	11	,	,	PUNCT
finefocus-5274	188	12	s.	s.	PROPN
finefocus-5274	188	13	u.	u.	PROPN
finefocus-5274	188	14	,	,	PUNCT
finefocus-5274	188	15	ishqi	ishqi	PROPN
finefocus-5274	188	16	,	,	PUNCT
finefocus-5274	188	17	h.	h.	PROPN
finefocus-5274	188	18	m.	m.	PROPN
finefocus-5274	188	19	,	,	PUNCT
finefocus-5274	188	20	&	&	CCONJ
finefocus-5274	188	21	tabish	tabish	PROPN
finefocus-5274	188	22	,	,	PUNCT
finefocus-5274	188	23	m.	m.	NOUN
finefocus-5274	188	24	(	(	PUNCT
finefocus-5274	188	25	2015	2015	NUM
finefocus-5274	188	26	)	)	PUNCT
finefocus-5274	188	27	.	.	PUNCT
finefocus-5274	189	1	ibuprofen	ibuprofen	PROPN
finefocus-5274	189	2	causes	cause	VERB
finefocus-5274	189	3	photocleavage	photocleavage	NOUN
finefocus-5274	189	4	through	through	ADP
finefocus-5274	189	5	ros	ros	PROPN
finefocus-5274	189	6	generation	generation	NOUN
finefocus-5274	189	7	and	and	CCONJ
finefocus-5274	189	8	intercalates	intercalate	NOUN
finefocus-5274	189	9	with	with	ADP
finefocus-5274	189	10	dna	dna	PROPN
finefocus-5274	189	11	:	:	PUNCT
finefocus-5274	189	12	a	a	DET
finefocus-5274	189	13	combined	combined	ADJ
finefocus-5274	189	14	biophysical	biophysical	ADJ
finefocus-5274	189	15	and	and	CCONJ
finefocus-5274	189	16	molecular	molecular	ADJ
finefocus-5274	189	17	docking	docking	NOUN
finefocus-5274	189	18	approach	approach	NOUN
finefocus-5274	189	19	.	.	PUNCT
finefocus-5274	190	1	physical	physical	ADJ
finefocus-5274	190	2	chemistry	chemistry	NOUN
finefocus-5274	190	3	chemical	chemical	PROPN
finefocus-5274	190	4	physics	physics	PROPN
finefocus-5274	190	5	:	:	PUNCT
finefocus-5274	190	6	pccp	pccp	PROPN
finefocus-5274	190	7	,	,	PUNCT
finefocus-5274	190	8	17(21	17(21	PROPN
finefocus-5274	190	9	)	)	PUNCT
finefocus-5274	190	10	,	,	PUNCT
finefocus-5274	190	11	13837–13850	13837–13850	NUM
finefocus-5274	190	12	.	.	PUNCT
finefocus-5274	191	1	https://doi.org/10.1039/c5cp00272a	https://doi.org/10.1039/c5cp00272a	NUM
finefocus-5274	191	2	18	18	NUM
finefocus-5274	191	3	.	.	PUNCT
finefocus-5274	192	1	soumya	soumya	PROPN
finefocus-5274	192	2	,	,	PUNCT
finefocus-5274	192	3	s.	s.	PROPN
finefocus-5274	192	4	,	,	PUNCT
finefocus-5274	192	5	&	&	CCONJ
finefocus-5274	192	6	joe	joe	PROPN
finefocus-5274	192	7	,	,	PUNCT
finefocus-5274	192	8	i.	i.	PROPN
finefocus-5274	192	9	h.	h.	PROPN
finefocus-5274	192	10	(	(	PUNCT
finefocus-5274	192	11	2021	2021	NUM
finefocus-5274	192	12	)	)	PUNCT
finefocus-5274	192	13	.	.	PUNCT
finefocus-5274	193	1	a	a	DET
finefocus-5274	193	2	combined	combined	ADJ
finefocus-5274	193	3	experimental	experimental	ADJ
finefocus-5274	193	4	and	and	CCONJ
finefocus-5274	193	5	quantum	quantum	ADJ
finefocus-5274	193	6	chemical	chemical	NOUN
finefocus-5274	193	7	study	study	NOUN
finefocus-5274	193	8	on	on	ADP
finefocus-5274	193	9	molecular	molecular	ADJ
finefocus-5274	193	10	structure	structure	NOUN
finefocus-5274	193	11	,	,	PUNCT
finefocus-5274	193	12	spectroscopic	spectroscopic	ADJ
finefocus-5274	193	13	properties	property	NOUN
finefocus-5274	193	14	and	and	CCONJ
finefocus-5274	193	15	biological	biological	ADJ
finefocus-5274	193	16	activity	activity	NOUN
finefocus-5274	193	17	of	of	ADP
finefocus-5274	193	18	anti	anti	ADJ
finefocus-5274	193	19	-	-	ADJ
finefocus-5274	193	20	inflammatory	inflammatory	ADJ
finefocus-5274	193	21	glucocorticosteroid	glucocorticosteroid	NOUN
finefocus-5274	193	22	drug	drug	NOUN
finefocus-5274	193	23	,	,	PUNCT
finefocus-5274	193	24	dexamethasone	dexamethasone	NOUN
finefocus-5274	193	25	.	.	PUNCT
finefocus-5274	193	26	journal	journal	PROPN
finefocus-5274	193	27	of	of	ADP
finefocus-5274	193	28	molecular	molecular	ADJ
finefocus-5274	193	29	structure	structure	NOUN
finefocus-5274	193	30	,	,	PUNCT
finefocus-5274	193	31	1245	1245	NUM
finefocus-5274	193	32	,	,	PUNCT
finefocus-5274	193	33	130999	130999	NUM
finefocus-5274	193	34	.	.	PUNCT
finefocus-5274	194	1	https://doi.org/10.1016/j.molstruc.2021.130999	https://doi.org/10.1016/j.molstruc.2021.130999	PROPN
finefocus-5274	194	2	19	19	NUM
finefocus-5274	194	3	.	.	PUNCT
finefocus-5274	195	1	tewey	tewey	PROPN
finefocus-5274	195	2	,	,	PUNCT
finefocus-5274	195	3	k.	k.	PROPN
finefocus-5274	195	4	m.	m.	PROPN
finefocus-5274	195	5	,	,	PUNCT
finefocus-5274	195	6	rowe	rowe	PROPN
finefocus-5274	195	7	,	,	PUNCT
finefocus-5274	195	8	t.	t.	PROPN
finefocus-5274	195	9	c.	c.	PROPN
finefocus-5274	195	10	,	,	PUNCT
finefocus-5274	195	11	yang	yang	PROPN
finefocus-5274	195	12	,	,	PUNCT
finefocus-5274	195	13	l.	l.	PROPN
finefocus-5274	195	14	,	,	PUNCT
finefocus-5274	195	15	halligan	halligan	PROPN
finefocus-5274	195	16	,	,	PUNCT
finefocus-5274	195	17	b.	b.	PROPN
finefocus-5274	195	18	d.	d.	PROPN
finefocus-5274	195	19	,	,	PUNCT
finefocus-5274	195	20	&	&	CCONJ
finefocus-5274	195	21	liu	liu	PROPN
finefocus-5274	195	22	,	,	PUNCT
finefocus-5274	195	23	l.	l.	PROPN
finefocus-5274	195	24	f.	f.	PROPN
finefocus-5274	195	25	(	(	PUNCT
finefocus-5274	195	26	1984	1984	NUM
finefocus-5274	195	27	)	)	PUNCT
finefocus-5274	195	28	.	.	PUNCT
finefocus-5274	196	1	adriamycin	adriamycin	NOUN
finefocus-5274	196	2	-	-	PUNCT
finefocus-5274	196	3	induced	induce	VERB
finefocus-5274	196	4	dna	dna	PROPN
finefocus-5274	196	5	damage	damage	NOUN
finefocus-5274	196	6	mediated	mediate	VERB
finefocus-5274	196	7	by	by	ADP
finefocus-5274	196	8	mammalian	mammalian	ADJ
finefocus-5274	196	9	dna	dna	PROPN
finefocus-5274	196	10	topoisomerase	topoisomerase	PROPN
finefocus-5274	196	11	ii	ii	PROPN
finefocus-5274	196	12	.	.	PUNCT
finefocus-5274	197	1	science	science	PROPN
finefocus-5274	197	2	,	,	PUNCT
finefocus-5274	197	3	226(4673	226(4673	NUM
finefocus-5274	197	4	)	)	PUNCT
finefocus-5274	197	5	,	,	PUNCT
finefocus-5274	197	6	466–468	466–468	NUM
finefocus-5274	197	7	.	.	PUNCT
finefocus-5274	197	8	https://doi.org/10.1126/science.6093249	https://doi.org/10.1126/science.6093249	PROPN
finefocus-5274	197	9	20	20	NUM
finefocus-5274	197	10	.	.	PUNCT
finefocus-5274	198	1	mimnaugh	mimnaugh	PROPN
finefocus-5274	198	2	,	,	PUNCT
finefocus-5274	198	3	e.	e.	PROPN
finefocus-5274	198	4	g.	g.	PROPN
finefocus-5274	198	5	,	,	PUNCT
finefocus-5274	198	6	trush	trush	NOUN
finefocus-5274	198	7	,	,	PUNCT
finefocus-5274	198	8	m.	m.	NOUN
finefocus-5274	198	9	a.	a.	PROPN
finefocus-5274	198	10	,	,	PUNCT
finefocus-5274	198	11	bhatnagar	bhatnagar	NOUN
finefocus-5274	198	12	,	,	PUNCT
finefocus-5274	198	13	m.	m.	NOUN
finefocus-5274	198	14	,	,	PUNCT
finefocus-5274	198	15	&	&	CCONJ
finefocus-5274	198	16	gram	gram	PROPN
finefocus-5274	198	17	,	,	PUNCT
finefocus-5274	198	18	t.	t.	PROPN
finefocus-5274	198	19	e.	e.	PROPN
finefocus-5274	198	20	(	(	PUNCT
finefocus-5274	198	21	1985	1985	NUM
finefocus-5274	198	22	)	)	PUNCT
finefocus-5274	198	23	.	.	PUNCT
finefocus-5274	199	1	enhancement	enhancement	NOUN
finefocus-5274	199	2	of	of	ADP
finefocus-5274	199	3	reactive	reactive	ADJ
finefocus-5274	199	4	oxygen	oxygen	NOUN
finefocus-5274	199	5	-	-	PUNCT
finefocus-5274	199	6	dependent	dependent	ADJ
finefocus-5274	199	7	mitochondrial	mitochondrial	ADJ
finefocus-5274	199	8	membrane	membrane	NOUN
finefocus-5274	199	9	lipid	lipid	NOUN
finefocus-5274	199	10	peroxidation	peroxidation	NOUN
finefocus-5274	199	11	by	by	ADP
finefocus-5274	199	12	the	the	DET
finefocus-5274	199	13	anticancer	anticancer	NOUN
finefocus-5274	199	14	drug	drug	NOUN
finefocus-5274	199	15	adriamycin	adriamycin	NOUN
finefocus-5274	199	16	.	.	PUNCT
finefocus-5274	200	1	biochemical	biochemical	ADJ
finefocus-5274	200	2	pharmacology	pharmacology	NOUN
finefocus-5274	200	3	,	,	PUNCT
finefocus-5274	200	4	34(6	34(6	NOUN
finefocus-5274	200	5	)	)	PUNCT
finefocus-5274	200	6	,	,	PUNCT
finefocus-5274	200	7	847–856	847–856	NUM
finefocus-5274	200	8	.	.	PUNCT
finefocus-5274	201	1	https://doi.org/10.1016/0006-2952(85)90766-x	https://doi.org/10.1016/0006-2952(85)90766-x	PROPN
finefocus-5274	201	2	21	21	NUM
finefocus-5274	201	3	.	.	PUNCT
finefocus-5274	202	1	zhang	zhang	PROPN
finefocus-5274	202	2	,	,	PUNCT
finefocus-5274	202	3	h.	h.	PROPN
finefocus-5274	202	4	,	,	PUNCT
finefocus-5274	202	5	gao	gao	PROPN
finefocus-5274	202	6	,	,	PUNCT
finefocus-5274	202	7	y.	y.	PROPN
finefocus-5274	202	8	g.	g.	PROPN
finefocus-5274	202	9	,	,	PUNCT
finefocus-5274	202	10	van	van	PROPN
finefocus-5274	202	11	der	der	PROPN
finefocus-5274	202	12	marel	marel	PROPN
finefocus-5274	202	13	,	,	PUNCT
finefocus-5274	202	14	g.	g.	PROPN
finefocus-5274	202	15	a.	a.	PROPN
finefocus-5274	202	16	,	,	PUNCT
finefocus-5274	202	17	van	van	PROPN
finefocus-5274	202	18	boom	boom	NOUN
finefocus-5274	202	19	,	,	PUNCT
finefocus-5274	202	20	j.	j.	PROPN
finefocus-5274	202	21	h.	h.	PROPN
finefocus-5274	202	22	,	,	PUNCT
finefocus-5274	202	23	&	&	CCONJ
finefocus-5274	202	24	wang	wang	PROPN
finefocus-5274	202	25	,	,	PUNCT
finefocus-5274	202	26	a.	a.	PROPN
finefocus-5274	202	27	h.	h.	PROPN
finefocus-5274	202	28	(	(	PUNCT
finefocus-5274	202	29	1993	1993	NUM
finefocus-5274	202	30	)	)	PUNCT
finefocus-5274	202	31	.	.	PUNCT
finefocus-5274	203	1	simultaneous	simultaneous	ADJ
finefocus-5274	203	2	incorporations	incorporation	NOUN
finefocus-5274	203	3	of	of	ADP
finefocus-5274	203	4	two	two	NUM
finefocus-5274	203	5	anticancer	anticancer	NOUN
finefocus-5274	203	6	drugs	drug	NOUN
finefocus-5274	203	7	into	into	ADP
finefocus-5274	203	8	dna	dna	PROPN
finefocus-5274	203	9	.	.	PUNCT
finefocus-5274	204	1	the	the	DET
finefocus-5274	204	2	structures	structure	NOUN
finefocus-5274	204	3	of	of	ADP
finefocus-5274	204	4	formaldehyde	formaldehyde	NOUN
finefocus-5274	204	5	-	-	PUNCT
finefocus-5274	204	6	cross	cross	NOUN
finefocus-5274	204	7	-	-	ADJ
finefocus-5274	204	8	linked	link	VERB
finefocus-5274	204	9	adducts	adduct	NOUN
finefocus-5274	204	10	of	of	ADP
finefocus-5274	204	11	daunorubicin	daunorubicin	NOUN
finefocus-5274	204	12	-	-	PUNCT
finefocus-5274	204	13	d(cg(arac)gcg	d(cg(arac)gcg	NOUN
finefocus-5274	204	14	)	)	PUNCT
finefocus-5274	204	15	and	and	CCONJ
finefocus-5274	204	16	doxorubicin	doxorubicin	PROPN
finefocus-5274	204	17	-	-	PUNCT
finefocus-5274	204	18	d(ca(arac	d(ca(arac	NOUN
finefocus-5274	204	19	)	)	PUNCT
finefocus-5274	204	20	gtg	gtg	NOUN
finefocus-5274	204	21	)	)	PUNCT
finefocus-5274	204	22	complexes	complex	NOUN
finefocus-5274	204	23	at	at	ADP
finefocus-5274	204	24	high	high	ADJ
finefocus-5274	204	25	resolution	resolution	NOUN
finefocus-5274	204	26	.	.	PUNCT
finefocus-5274	205	1	journal	journal	NOUN
finefocus-5274	205	2	of	of	ADP
finefocus-5274	205	3	biological	biological	ADJ
finefocus-5274	205	4	chemistry	chemistry	NOUN
finefocus-5274	205	5	,	,	PUNCT
finefocus-5274	205	6	268(14	268(14	NUM
finefocus-5274	205	7	)	)	PUNCT
finefocus-5274	205	8	,	,	PUNCT
finefocus-5274	205	9	10095–10101	10095–10101	NUM
finefocus-5274	205	10	.	.	PUNCT
finefocus-5274	206	1	https://doi.org/10.1016/s0021-9258(18)82176-7	https://doi.org/10.1016/s0021-9258(18)82176-7	PROPN
finefocus-5274	206	2	22	22	NUM
finefocus-5274	206	3	.	.	PUNCT
finefocus-5274	207	1	du	du	PROPN
finefocus-5274	207	2	,	,	PUNCT
finefocus-5274	207	3	h.	h.	PROPN
finefocus-5274	207	4	,	,	PUNCT
finefocus-5274	207	5	huang	huang	PROPN
finefocus-5274	207	6	,	,	PUNCT
finefocus-5274	207	7	y.	y.	PROPN
finefocus-5274	207	8	,	,	PUNCT
finefocus-5274	207	9	hou	hou	PROPN
finefocus-5274	207	10	,	,	PUNCT
finefocus-5274	207	11	x.	x.	PROPN
finefocus-5274	207	12	,	,	PUNCT
finefocus-5274	207	13	quan	quan	PROPN
finefocus-5274	207	14	,	,	PUNCT
finefocus-5274	207	15	x.	x.	PROPN
finefocus-5274	207	16	,	,	PUNCT
finefocus-5274	207	17	jiang	jiang	PROPN
finefocus-5274	207	18	,	,	PUNCT
finefocus-5274	207	19	j.	j.	PROPN
finefocus-5274	207	20	,	,	PUNCT
finefocus-5274	207	21	wei	wei	PROPN
finefocus-5274	207	22	,	,	PUNCT
finefocus-5274	207	23	x.	x.	PROPN
finefocus-5274	207	24	,	,	PUNCT
finefocus-5274	207	25	liu	liu	PROPN
finefocus-5274	207	26	,	,	PUNCT
finefocus-5274	207	27	y.	y.	PROPN
finefocus-5274	207	28	,	,	PUNCT
finefocus-5274	207	29	li	li	PROPN
finefocus-5274	207	30	,	,	PUNCT
finefocus-5274	207	31	h.	h.	PROPN
finefocus-5274	207	32	,	,	PUNCT
finefocus-5274	207	33	wang	wang	PROPN
finefocus-5274	207	34	,	,	PUNCT
finefocus-5274	207	35	p.	p.	PROPN
finefocus-5274	207	36	,	,	PUNCT
finefocus-5274	207	37	zhan	zhan	PROPN
finefocus-5274	207	38	,	,	PUNCT
finefocus-5274	207	39	m.	m.	NOUN
finefocus-5274	207	40	,	,	PUNCT
finefocus-5274	207	41	ai	ai	VERB
finefocus-5274	207	42	,	,	PUNCT
finefocus-5274	207	43	x.	x.	PROPN
finefocus-5274	207	44	,	,	PUNCT
finefocus-5274	207	45	lu	lu	PROPN
finefocus-5274	207	46	,	,	PUNCT
finefocus-5274	207	47	l.	l.	PROPN
finefocus-5274	207	48	,	,	PUNCT
finefocus-5274	207	49	yuan	yuan	PROPN
finefocus-5274	207	50	,	,	PUNCT
finefocus-5274	207	51	s.	s.	PROPN
finefocus-5274	207	52	,	,	PUNCT
finefocus-5274	207	53	&	&	CCONJ
finefocus-5274	207	54	sun	sun	PROPN
finefocus-5274	207	55	,	,	PUNCT
finefocus-5274	207	56	l.	l.	PROPN
finefocus-5274	207	57	(	(	PUNCT
finefocus-5274	207	58	2018	2018	NUM
finefocus-5274	207	59	)	)	PUNCT
finefocus-5274	207	60	.	.	PUNCT
finefocus-5274	208	1	two	two	NUM
finefocus-5274	208	2	novel	novel	ADJ
finefocus-5274	208	3	camptothecin	camptothecin	NOUN
finefocus-5274	208	4	derivatives	derivative	NOUN
finefocus-5274	208	5	inhibit	inhibit	VERB
finefocus-5274	208	6	colorectal	colorectal	ADJ
finefocus-5274	208	7	cancer	cancer	NOUN
finefocus-5274	208	8	proliferation	proliferation	NOUN
finefocus-5274	208	9	via	via	ADP
finefocus-5274	208	10	induction	induction	NOUN
finefocus-5274	208	11	of	of	ADP
finefocus-5274	208	12	cell	cell	NOUN
finefocus-5274	208	13	cycle	cycle	NOUN
finefocus-5274	208	14	arrest	arrest	NOUN
finefocus-5274	208	15	and	and	CCONJ
finefocus-5274	208	16	apoptosis	apoptosis	NOUN
finefocus-5274	208	17	in	in	ADP
finefocus-5274	208	18	vitro	vitro	X
finefocus-5274	208	19	and	and	CCONJ
finefocus-5274	208	20	in	in	ADP
finefocus-5274	208	21	vivo	vivo	NOUN
finefocus-5274	208	22	.	.	PUNCT
finefocus-5274	209	1	european	european	ADJ
finefocus-5274	209	2	journal	journal	PROPN
finefocus-5274	209	3	of	of	ADP
finefocus-5274	209	4	pharmaceutical	pharmaceutical	NOUN
finefocus-5274	209	5	sciences	science	NOUN
finefocus-5274	209	6	,	,	PUNCT
finefocus-5274	209	7	123	123	NUM
finefocus-5274	209	8	,	,	PUNCT
finefocus-5274	209	9	546–559	546–559	NUM
finefocus-5274	209	10	.	.	PUNCT
finefocus-5274	210	1	https://doi.org/10.1016/j.ejps.2018.08.018	https://doi.org/10.1016/j.ejps.2018.08.018	NOUN
finefocus-5274	210	2	23	23	NUM
finefocus-5274	210	3	.	.	PUNCT
finefocus-5274	211	1	hsiang	hsiang	PROPN
finefocus-5274	211	2	,	,	PUNCT
finefocus-5274	211	3	y.	y.	PROPN
finefocus-5274	211	4	h.	h.	PROPN
finefocus-5274	211	5	,	,	PUNCT
finefocus-5274	211	6	hertzberg	hertzberg	PROPN
finefocus-5274	211	7	,	,	PUNCT
finefocus-5274	211	8	r.	r.	PROPN
finefocus-5274	211	9	,	,	PUNCT
finefocus-5274	211	10	hecht	hecht	PROPN
finefocus-5274	211	11	,	,	PUNCT
finefocus-5274	211	12	s.	s.	PROPN
finefocus-5274	211	13	,	,	PUNCT
finefocus-5274	211	14	&	&	CCONJ
finefocus-5274	211	15	liu	liu	PROPN
finefocus-5274	211	16	,	,	PUNCT
finefocus-5274	211	17	l.	l.	PROPN
finefocus-5274	211	18	f.	f.	PROPN
finefocus-5274	211	19	(	(	PUNCT
finefocus-5274	211	20	1985	1985	NUM
finefocus-5274	211	21	)	)	PUNCT
finefocus-5274	211	22	.	.	PUNCT
finefocus-5274	212	1	camptothecin	camptothecin	PROPN
finefocus-5274	212	2	induces	induce	VERB
finefocus-5274	212	3	protein	protein	NOUN
finefocus-5274	212	4	-	-	PUNCT
finefocus-5274	212	5	linked	link	VERB
finefocus-5274	212	6	dna	dna	PROPN
finefocus-5274	212	7	breaks	break	NOUN
finefocus-5274	212	8	via	via	ADP
finefocus-5274	212	9	mammalian	mammalian	ADJ
finefocus-5274	212	10	dna	dna	PROPN
finefocus-5274	212	11	topoisomerase	topoisomerase	PROPN
finefocus-5274	212	12	i.	i.	PROPN
finefocus-5274	212	13	journal	journal	PROPN
finefocus-5274	212	14	of	of	ADP
finefocus-5274	212	15	biological	biological	ADJ
finefocus-5274	212	16	chemistry	chemistry	NOUN
finefocus-5274	212	17	,	,	PUNCT
finefocus-5274	212	18	260(27	260(27	NUM
finefocus-5274	212	19	)	)	PUNCT
finefocus-5274	212	20	,	,	PUNCT
finefocus-5274	212	21	14873–14878	14873–14878	NUM
finefocus-5274	212	22	.	.	PUNCT
finefocus-5274	213	1	https://doi.org/10.1016/s0021-9258(17)38654-4	https://doi.org/10.1016/s0021-9258(17)38654-4	PROPN
finefocus-5274	213	2	https://doi.org/10.1158/0008-5472.can-07-1038	https://doi.org/10.1158/0008-5472.can-07-1038	NUM
finefocus-5274	213	3	https://doi.org/10.1128/jb.172.12.7260-7262.1990	https://doi.org/10.1128/jb.172.12.7260-7262.1990	ADP
finefocus-5274	213	4	https://doi.org/10.1016/0027-5107(87)90262-4	https://doi.org/10.1016/0027-5107(87)90262-4	PROPN
finefocus-5274	213	5	https://doi.org/10.1039/c5cp00272a	https://doi.org/10.1039/c5cp00272a	NUM
finefocus-5274	213	6	https://doi.org/10.1016/j.molstruc.2021.130999	https://doi.org/10.1016/j.molstruc.2021.130999	PROPN
finefocus-5274	213	7	https://doi.org/10.1126/science.6093249	https://doi.org/10.1126/science.6093249	NOUN
finefocus-5274	214	1	https://doi.org/10.1016/0006-2952(85)90766-x	https://doi.org/10.1016/0006-2952(85)90766-x	NOUN
finefocus-5274	214	2	https://doi.org/10.1016/s0021-9258(18)82176-7	https://doi.org/10.1016/s0021-9258(18)82176-7	ADJ
finefocus-5274	214	3	https://doi.org/10.1016/j.ejps.2018.08.018	https://doi.org/10.1016/j.ejps.2018.08.018	PROPN
finefocus-5274	214	4	https://doi.org/10.1016/s0021-9258(17)38654-4	https://doi.org/10.1016/s0021-9258(17)38654-4	PROPN
finefocus-5274	214	5	swain	swain	PROPN
finefocus-5274	214	6	et	et	PROPN
finefocus-5274	214	7	al	al	PROPN
finefocus-5274	214	8	.	.	PUNCT
finefocus-5274	215	1	|	|	ADV
finefocus-5274	215	2	analyzing	analyze	VERB
finefocus-5274	215	3	selected	select	VERB
finefocus-5274	215	4	fda	fda	PROPN
finefocus-5274	215	5	approved	approve	VERB
finefocus-5274	215	6	drugs	drug	NOUN
finefocus-5274	215	7	for	for	ADP
finefocus-5274	215	8	effects	effect	NOUN
finefocus-5274	215	9	on	on	ADP
finefocus-5274	215	10	template	template	NOUN
finefocus-5274	215	11	switch	switch	NOUN
finefocus-5274	215	12	mutagenesis	mutagenesis	NOUN
finefocus-5274	215	13	in	in	ADP
finefocus-5274	215	14	e.	e.	PROPN
finefocus-5274	215	15	coli	coli	PROPN
finefocus-5274	215	16	23	23	NUM
finefocus-5274	215	17	24	24	NUM
finefocus-5274	215	18	.	.	PUNCT
finefocus-5274	216	1	hsiang	hsiang	PROPN
finefocus-5274	216	2	,	,	PUNCT
finefocus-5274	216	3	y.-h	y.-h	PROPN
finefocus-5274	216	4	.	.	PROPN
finefocus-5274	216	5	,	,	PUNCT
finefocus-5274	216	6	lihou	lihou	PROPN
finefocus-5274	216	7	,	,	PUNCT
finefocus-5274	216	8	m.	m.	NOUN
finefocus-5274	216	9	g.	g.	PROPN
finefocus-5274	216	10	,	,	PUNCT
finefocus-5274	216	11	&	&	CCONJ
finefocus-5274	216	12	liu	liu	PROPN
finefocus-5274	216	13	,	,	PUNCT
finefocus-5274	216	14	l.	l.	PROPN
finefocus-5274	216	15	f.	f.	PROPN
finefocus-5274	216	16	(	(	PUNCT
finefocus-5274	216	17	1989	1989	NUM
finefocus-5274	216	18	)	)	PUNCT
finefocus-5274	216	19	.	.	PUNCT
finefocus-5274	217	1	arrest	arrest	NOUN
finefocus-5274	217	2	of	of	ADP
finefocus-5274	217	3	replication	replication	NOUN
finefocus-5274	217	4	forks	fork	NOUN
finefocus-5274	217	5	by	by	ADP
finefocus-5274	217	6	drug	drug	NOUN
finefocus-5274	217	7	-	-	PUNCT
finefocus-5274	217	8	stabilized	stabilize	VERB
finefocus-5274	217	9	topoisomerase	topoisomerase	NOUN
finefocus-5274	217	10	i	i	PROPN
finefocus-5274	217	11	-	-	PUNCT
finefocus-5274	217	12	dna	dna	NOUN
finefocus-5274	217	13	cleavable	cleavable	ADJ
finefocus-5274	217	14	complexes	complex	NOUN
finefocus-5274	217	15	as	as	ADP
finefocus-5274	217	16	a	a	DET
finefocus-5274	217	17	mechanism	mechanism	NOUN
finefocus-5274	217	18	of	of	ADP
finefocus-5274	217	19	cell	cell	NOUN
finefocus-5274	217	20	killing	kill	VERB
finefocus-5274	217	21	by	by	ADP
finefocus-5274	217	22	camptothecin1	camptothecin1	NOUN
finefocus-5274	217	23	.	.	PUNCT
finefocus-5274	218	1	cancer	cancer	NOUN
finefocus-5274	218	2	research	research	NOUN
finefocus-5274	218	3	,	,	PUNCT
finefocus-5274	218	4	49(18	49(18	NUM
finefocus-5274	218	5	)	)	PUNCT
finefocus-5274	218	6	,	,	PUNCT
finefocus-5274	218	7	5077–5082	5077–5082	NUM
finefocus-5274	218	8	.	.	PUNCT
finefocus-5274	219	1	25	25	NUM
finefocus-5274	219	2	.	.	X
finefocus-5274	219	3	laranjo	laranjo	PROPN
finefocus-5274	219	4	,	,	PUNCT
finefocus-5274	219	5	l.	l.	PROPN
finefocus-5274	219	6	t.	t.	PROPN
finefocus-5274	219	7	,	,	PUNCT
finefocus-5274	219	8	gross	gross	PROPN
finefocus-5274	219	9	,	,	PUNCT
finefocus-5274	219	10	s.	s.	PROPN
finefocus-5274	219	11	j.	j.	PROPN
finefocus-5274	219	12	,	,	PUNCT
finefocus-5274	219	13	zeiger	zeiger	NOUN
finefocus-5274	219	14	,	,	PUNCT
finefocus-5274	219	15	d.	d.	PROPN
finefocus-5274	219	16	m.	m.	PROPN
finefocus-5274	219	17	,	,	PUNCT
finefocus-5274	219	18	&	&	CCONJ
finefocus-5274	219	19	lovett	lovett	PROPN
finefocus-5274	219	20	,	,	PUNCT
finefocus-5274	219	21	s.	s.	PROPN
finefocus-5274	219	22	t.	t.	PROPN
finefocus-5274	219	23	(	(	PUNCT
finefocus-5274	219	24	2017	2017	NUM
finefocus-5274	219	25	)	)	PUNCT
finefocus-5274	219	26	.	.	PUNCT
finefocus-5274	220	1	ssb	ssb	PROPN
finefocus-5274	220	2	recruitment	recruitment	NOUN
finefocus-5274	220	3	of	of	ADP
finefocus-5274	220	4	exonuclease	exonuclease	NOUN
finefocus-5274	220	5	i	i	PRON
finefocus-5274	220	6	aborts	abort	VERB
finefocus-5274	220	7	template	template	NOUN
finefocus-5274	220	8	-	-	PUNCT
finefocus-5274	220	9	switching	switching	NOUN
finefocus-5274	220	10	in	in	ADP
finefocus-5274	220	11	escherichia	escherichia	NOUN
finefocus-5274	220	12	coli	coli	NOUN
finefocus-5274	220	13	.	.	PUNCT
finefocus-5274	221	1	dna	dna	PROPN
finefocus-5274	221	2	repair	repair	NOUN
finefocus-5274	221	3	,	,	PUNCT
finefocus-5274	221	4	57	57	NUM
finefocus-5274	221	5	,	,	PUNCT
finefocus-5274	221	6	12–16	12–16	NUM
finefocus-5274	221	7	.	.	PUNCT
finefocus-5274	222	1	h	h	PROPN
finefocus-5274	222	2	ttps://doi.org/10.1016/j.dnarep.2017.05.007	ttps://doi.org/10.1016/j.dnarep.2017.05.007	VERB
finefocus-5274	222	3	26	26	NUM
finefocus-5274	222	4	.	.	PUNCT
finefocus-5274	223	1	de	de	PROPN
finefocus-5274	223	2	sousa	sousa	PROPN
finefocus-5274	223	3	cavalcante	cavalcante	PROPN
finefocus-5274	223	4	,	,	PUNCT
finefocus-5274	223	5	l.	l.	PROPN
finefocus-5274	223	6	,	,	PUNCT
finefocus-5274	223	7	&	&	CCONJ
finefocus-5274	223	8	monteiro	monteiro	PROPN
finefocus-5274	223	9	,	,	PUNCT
finefocus-5274	223	10	g.	g.	PROPN
finefocus-5274	223	11	(	(	PUNCT
finefocus-5274	223	12	2014	2014	NUM
finefocus-5274	223	13	)	)	PUNCT
finefocus-5274	223	14	.	.	PUNCT
finefocus-5274	224	1	gemcitabine	gemcitabine	NOUN
finefocus-5274	224	2	:	:	PUNCT
finefocus-5274	224	3	metabolism	metabolism	NOUN
finefocus-5274	224	4	and	and	CCONJ
finefocus-5274	224	5	molecular	molecular	ADJ
finefocus-5274	224	6	mechanisms	mechanism	NOUN
finefocus-5274	224	7	of	of	ADP
finefocus-5274	224	8	action	action	NOUN
finefocus-5274	224	9	,	,	PUNCT
finefocus-5274	224	10	sensitivity	sensitivity	NOUN
finefocus-5274	224	11	and	and	CCONJ
finefocus-5274	224	12	chemoresistance	chemoresistance	NOUN
finefocus-5274	224	13	in	in	ADP
finefocus-5274	224	14	pancreatic	pancreatic	ADJ
finefocus-5274	224	15	cancer	cancer	NOUN
finefocus-5274	224	16	.	.	PUNCT
finefocus-5274	225	1	european	european	PROPN
finefocus-5274	225	2	journal	journal	PROPN
finefocus-5274	225	3	of	of	ADP
finefocus-5274	225	4	pharmacology	pharmacology	NOUN
finefocus-5274	225	5	,	,	PUNCT
finefocus-5274	225	6	741	741	NUM
finefocus-5274	225	7	,	,	PUNCT
finefocus-5274	225	8	8–16	8–16	PROPN
finefocus-5274	225	9	.	.	PUNCT
finefocus-5274	226	1	https://doi.org/10.1016/j.ejphar.2014.07.041	https://doi.org/10.1016/j.ejphar.2014.07.041	PROPN
finefocus-5274	226	2	https://doi.org/10.1016/j.dnarep.2017.05.007	https://doi.org/10.1016/j.dnarep.2017.05.007	VERB
finefocus-5274	226	3	https://doi.org/10.1016/j.dnarep.2017.05.007	https://doi.org/10.1016/j.dnarep.2017.05.007	PROPN
finefocus-5274	226	4	https://doi.org/10.1016/j.ejphar.2014.07.041	https://doi.org/10.1016/j.ejphar.2014.07.041	PROPN
finefocus-5274	226	5	analyzing	analyzing	NOUN
finefocus-5274	226	6	selected	select	VERB
finefocus-5274	226	7	fda	fda	PROPN
finefocus-5274	226	8	approved	approve	VERB
finefocus-5274	226	9	drugs	drug	NOUN
finefocus-5274	226	10	for	for	ADP
finefocus-5274	226	11	effects	effect	NOUN
finefocus-5274	226	12	on	on	ADP
finefocus-5274	226	13	template	template	NOUN
finefocus-5274	226	14	switch	switch	NOUN
finefocus-5274	226	15	mutagenesis	mutagenesis	NOUN
finefocus-5274	226	16	in	in	ADP
finefocus-5274	226	17	e.	e.	PROPN
finefocus-5274	226	18	coli	coli	PROPN
finefocus-5274	226	19	abstract	abstract	ADJ
finefocus-5274	226	20	introduction	introduction	NOUN
finefocus-5274	226	21	figure	figure	NOUN
finefocus-5274	226	22	1	1	NUM
finefocus-5274	226	23	.	.	PUNCT
finefocus-5274	227	1	quasi	quasi	ADJ
finefocus-5274	227	2	-	-	ADJ
finefocus-5274	227	3	palindrome	palindrome	ADJ
finefocus-5274	227	4	template	template	NOUN
finefocus-5274	227	5	-	-	PUNCT
finefocus-5274	227	6	switch	switch	NOUN
finefocus-5274	227	7	mutation	mutation	NOUN
finefocus-5274	227	8	mechanisms	mechanism	NOUN
finefocus-5274	227	9	methods	method	NOUN
finefocus-5274	227	10	figure	figure	VERB
finefocus-5274	227	11	2	2	NUM
finefocus-5274	227	12	.	.	PUNCT
finefocus-5274	227	13	mutational	mutational	ADJ
finefocus-5274	227	14	assay	assay	ADJ
finefocus-5274	227	15	methods	method	NOUN
finefocus-5274	227	16	figure	figure	VERB
finefocus-5274	227	17	3	3	NUM
finefocus-5274	227	18	.	.	PUNCT
finefocus-5274	227	19	mutation	mutation	NOUN
finefocus-5274	227	20	frequency	frequency	NOUN
finefocus-5274	227	21	of	of	ADP
finefocus-5274	227	22	gemcitabine	gemcitabine	NOUN
finefocus-5274	227	23	at	at	ADP
finefocus-5274	227	24	varying	vary	VERB
finefocus-5274	227	25	concentrations	concentration	NOUN
finefocus-5274	227	26	results	result	NOUN
finefocus-5274	227	27	figure	figure	VERB
finefocus-5274	227	28	4	4	NUM
finefocus-5274	227	29	.	.	PUNCT
finefocus-5274	227	30	mutation	mutation	NOUN
finefocus-5274	227	31	frequency	frequency	NOUN
finefocus-5274	227	32	of	of	ADP
finefocus-5274	227	33	ibuprofen	ibuprofen	NOUN
finefocus-5274	227	34	at	at	ADP
finefocus-5274	227	35	150	150	NUM
finefocus-5274	227	36	μm	μm	NUM
finefocus-5274	227	37	discussion	discussion	NOUN
finefocus-5274	227	38	figure	figure	NOUN
finefocus-5274	227	39	5	5	NUM
finefocus-5274	227	40	.	.	PUNCT
finefocus-5274	227	41	comparison	comparison	NOUN
finefocus-5274	227	42	of	of	ADP
finefocus-5274	227	43	mutation	mutation	NOUN
finefocus-5274	227	44	frequency	frequency	NOUN
finefocus-5274	227	45	of	of	ADP
finefocus-5274	227	46	cpt-11	cpt-11	PROPN
finefocus-5274	227	47	,	,	PUNCT
finefocus-5274	227	48	dexamethasone	dexamethasone	NOUN
finefocus-5274	227	49	,	,	PUNCT
finefocus-5274	227	50	and	and	CCONJ
finefocus-5274	227	51	doxorubicin	doxorubicin	PROPN
finefocus-5274	227	52	references	reference	NOUN