id	sid	tid	token	lemma	pos
finefocus-541	1	1	117pathogens	117pathogen	NOUN
finefocus-541	1	2	&	&	CCONJ
finefocus-541	1	3	antimicrobial	antimicrobial	ADJ
finefocus-541	1	4	factors	factor	NOUN
finefocus-541	1	5	•	•	ADP
finefocus-541	1	6	antibiotic	antibiotic	ADJ
finefocus-541	1	7	tolerance	tolerance	NOUN
finefocus-541	1	8	of	of	ADP
finefocus-541	1	9	burkholderia	burkholderia	NOUN
finefocus-541	1	10	:	:	PUNCT
finefocus-541	1	11	distinguishing	distinguish	VERB
finefocus-541	1	12	between	between	ADP
finefocus-541	1	13	classical	classical	ADJ
finefocus-541	1	14	resistance	resistance	NOUN
finefocus-541	1	15	and	and	CCONJ
finefocus-541	1	16	persistence	persistence	NOUN
finefocus-541	1	17	in	in	ADP
finefocus-541	1	18	a	a	DET
finefocus-541	1	19	macrophage	macrophage	ADJ
finefocus-541	1	20	infection	infection	NOUN
finefocus-541	1	21	model	model	NOUN
finefocus-541	1	22	crystal	crystal	PROPN
finefocus-541	1	23	collins	collins	PROPN
finefocus-541	1	24	and	and	CCONJ
finefocus-541	1	25	kara	kara	PROPN
finefocus-541	1	26	mosovsky	mosovsky	PROPN
finefocus-541	1	27	*	*	PROPN
finefocus-541	1	28	department	department	PROPN
finefocus-541	1	29	of	of	ADP
finefocus-541	1	30	biological	biological	ADJ
finefocus-541	1	31	sciences	science	NOUN
finefocus-541	1	32	,	,	PUNCT
finefocus-541	1	33	moravian	moravian	PROPN
finefocus-541	1	34	college	college	PROPN
finefocus-541	1	35	,	,	PUNCT
finefocus-541	1	36	bethlehem	bethlehem	PROPN
finefocus-541	1	37	,	,	PUNCT
finefocus-541	1	38	pa	pa	PROPN
finefocus-541	1	39	usa	usa	PROPN
finefocus-541	1	40	manuscript	manuscript	PROPN
finefocus-541	1	41	received	receive	VERB
finefocus-541	1	42	12	12	NUM
finefocus-541	1	43	may	may	PROPN
finefocus-541	1	44	2017	2017	NUM
finefocus-541	1	45	;	;	PUNCT
finefocus-541	1	46	accepted	accept	VERB
finefocus-541	1	47	27	27	NUM
finefocus-541	1	48	july	july	PROPN
finefocus-541	1	49	2017	2017	NUM
finefocus-541	1	50	copyright	copyright	NOUN
finefocus-541	1	51	2018	2018	NUM
finefocus-541	1	52	,	,	PUNCT
finefocus-541	1	53	fine	fine	ADJ
finefocus-541	1	54	focus	focus	NOUN
finefocus-541	1	55	.	.	PUNCT
finefocus-541	2	1	all	all	DET
finefocus-541	2	2	rights	right	NOUN
finefocus-541	2	3	reserved	reserve	VERB
finefocus-541	2	4	.	.	PUNCT
finefocus-541	3	1	118•	118•	PRON
finefocus-541	3	2	fine	fine	ADJ
finefocus-541	3	3	focus	focus	NOUN
finefocus-541	3	4	,	,	PUNCT
finefocus-541	3	5	vol	vol	NOUN
finefocus-541	3	6	.	.	PUNCT
finefocus-541	3	7	4(1	4(1	NOUN
finefocus-541	3	8	)	)	PUNCT
finefocus-541	3	9	burkholderia	burkholderia	NOUN
finefocus-541	3	10	pseudomallei	pseudomallei	NOUN
finefocus-541	3	11	is	be	AUX
finefocus-541	3	12	a	a	DET
finefocus-541	3	13	gram	gram	NOUN
finefocus-541	3	14	-	-	PUNCT
finefocus-541	3	15	negative	negative	ADJ
finefocus-541	3	16	bacillus	bacillus	NOUN
finefocus-541	3	17	and	and	CCONJ
finefocus-541	3	18	facultative	facultative	ADJ
finefocus-541	3	19	intracellular	intracellular	ADJ
finefocus-541	3	20	pathogen	pathogen	NOUN
finefocus-541	3	21	.	.	PUNCT
finefocus-541	4	1	it	it	PRON
finefocus-541	4	2	causes	cause	VERB
finefocus-541	4	3	the	the	DET
finefocus-541	4	4	disease	disease	NOUN
finefocus-541	4	5	melioidosis	melioidosis	NOUN
finefocus-541	4	6	,	,	PUNCT
finefocus-541	4	7	which	which	PRON
finefocus-541	4	8	is	be	AUX
finefocus-541	4	9	a	a	DET
finefocus-541	4	10	potentially	potentially	ADV
finefocus-541	4	11	fatal	fatal	ADJ
finefocus-541	4	12	human	human	ADJ
finefocus-541	4	13	disease	disease	NOUN
finefocus-541	4	14	found	find	VERB
finefocus-541	4	15	throughout	throughout	ADP
finefocus-541	4	16	the	the	DET
finefocus-541	4	17	world	world	NOUN
finefocus-541	4	18	but	but	CCONJ
finefocus-541	4	19	particularly	particularly	ADV
finefocus-541	4	20	in	in	ADP
finefocus-541	4	21	southeast	southeast	PROPN
finefocus-541	4	22	asia	asia	PROPN
finefocus-541	4	23	and	and	CCONJ
finefocus-541	4	24	northern	northern	PROPN
finefocus-541	4	25	australia	australia	PROPN
finefocus-541	4	26	.	.	PUNCT
finefocus-541	5	1	b.	b.	PROPN
finefocus-541	5	2	pseudomallei	pseudomallei	PROPN
finefocus-541	5	3	is	be	AUX
finefocus-541	5	4	inherently	inherently	ADV
finefocus-541	5	5	antibiotic	antibiotic	ADJ
finefocus-541	5	6	resistant	resistant	ADJ
finefocus-541	5	7	and	and	CCONJ
finefocus-541	5	8	therefore	therefore	ADV
finefocus-541	5	9	new	new	ADJ
finefocus-541	5	10	therapies	therapy	NOUN
finefocus-541	5	11	are	be	AUX
finefocus-541	5	12	needed	need	VERB
finefocus-541	5	13	to	to	PART
finefocus-541	5	14	combat	combat	VERB
finefocus-541	5	15	this	this	DET
finefocus-541	5	16	pathogen	pathogen	NOUN
finefocus-541	5	17	.	.	PUNCT
finefocus-541	6	1	previous	previous	ADJ
finefocus-541	6	2	studies	study	NOUN
finefocus-541	6	3	with	with	ADP
finefocus-541	6	4	the	the	DET
finefocus-541	6	5	related	relate	VERB
finefocus-541	6	6	organism	organism	NOUN
finefocus-541	6	7	burkholderia	burkholderia	NOUN
finefocus-541	6	8	thailandensis	thailandensis	NOUN
finefocus-541	6	9	have	have	AUX
finefocus-541	6	10	shown	show	VERB
finefocus-541	6	11	that	that	SCONJ
finefocus-541	6	12	the	the	DET
finefocus-541	6	13	antibiotic	antibiotic	ADJ
finefocus-541	6	14	ceftazidime	ceftazidime	NOUN
finefocus-541	6	15	does	do	AUX
finefocus-541	6	16	not	not	PART
finefocus-541	6	17	eliminate	eliminate	VERB
finefocus-541	6	18	all	all	DET
finefocus-541	6	19	bacteria	bacteria	NOUN
finefocus-541	6	20	in	in	ADP
finefocus-541	6	21	an	an	DET
finefocus-541	6	22	in	in	ADP
finefocus-541	6	23	vitro	vitro	X
finefocus-541	6	24	macrophage	macrophage	ADJ
finefocus-541	6	25	model	model	NOUN
finefocus-541	6	26	,	,	PUNCT
finefocus-541	6	27	and	and	CCONJ
finefocus-541	6	28	the	the	DET
finefocus-541	6	29	remaining	remain	VERB
finefocus-541	6	30	bacteria	bacteria	NOUN
finefocus-541	6	31	could	could	AUX
finefocus-541	6	32	still	still	ADV
finefocus-541	6	33	pose	pose	VERB
finefocus-541	6	34	a	a	DET
finefocus-541	6	35	health	health	NOUN
finefocus-541	6	36	threat	threat	NOUN
finefocus-541	6	37	to	to	ADP
finefocus-541	6	38	a	a	DET
finefocus-541	6	39	potential	potential	ADJ
finefocus-541	6	40	host	host	NOUN
finefocus-541	6	41	.	.	PUNCT
finefocus-541	7	1	due	due	ADP
finefocus-541	7	2	to	to	ADP
finefocus-541	7	3	their	their	PRON
finefocus-541	7	4	survival	survival	NOUN
finefocus-541	7	5	in	in	ADP
finefocus-541	7	6	the	the	DET
finefocus-541	7	7	presence	presence	NOUN
finefocus-541	7	8	of	of	ADP
finefocus-541	7	9	antibiotics	antibiotic	NOUN
finefocus-541	7	10	,	,	PUNCT
finefocus-541	7	11	we	we	PRON
finefocus-541	7	12	hypothesized	hypothesize	VERB
finefocus-541	7	13	that	that	SCONJ
finefocus-541	7	14	the	the	DET
finefocus-541	7	15	remaining	remain	VERB
finefocus-541	7	16	bacteria	bacteria	NOUN
finefocus-541	7	17	were	be	AUX
finefocus-541	7	18	one	one	NUM
finefocus-541	7	19	of	of	ADP
finefocus-541	7	20	two	two	NUM
finefocus-541	7	21	types	type	NOUN
finefocus-541	7	22	of	of	ADP
finefocus-541	7	23	antibiotic	antibiotic	ADJ
finefocus-541	7	24	tolerant	tolerant	ADJ
finefocus-541	7	25	cells	cell	NOUN
finefocus-541	7	26	:	:	PUNCT
finefocus-541	7	27	classically	classically	ADV
finefocus-541	7	28	antibiotic	antibiotic	ADJ
finefocus-541	7	29	resistant	resistant	ADJ
finefocus-541	7	30	cells	cell	NOUN
finefocus-541	7	31	or	or	CCONJ
finefocus-541	7	32	persister	persister	NOUN
finefocus-541	7	33	cells	cell	NOUN
finefocus-541	7	34	.	.	PUNCT
finefocus-541	8	1	to	to	PART
finefocus-541	8	2	test	test	VERB
finefocus-541	8	3	our	our	PRON
finefocus-541	8	4	hypothesis	hypothesis	NOUN
finefocus-541	8	5	we	we	PRON
finefocus-541	8	6	isolated	isolate	VERB
finefocus-541	8	7	the	the	DET
finefocus-541	8	8	bacteria	bacteria	NOUN
finefocus-541	8	9	that	that	PRON
finefocus-541	8	10	had	have	AUX
finefocus-541	8	11	survived	survive	VERB
finefocus-541	8	12	ceftazidime	ceftazidime	NOUN
finefocus-541	8	13	treatment	treatment	NOUN
finefocus-541	8	14	in	in	ADP
finefocus-541	8	15	the	the	DET
finefocus-541	8	16	macrophage	macrophage	ADJ
finefocus-541	8	17	infection	infection	NOUN
finefocus-541	8	18	model	model	NOUN
finefocus-541	8	19	and	and	CCONJ
finefocus-541	8	20	performed	perform	VERB
finefocus-541	8	21	additional	additional	ADJ
finefocus-541	8	22	in	in	ADP
finefocus-541	8	23	vitro	vitro	ADJ
finefocus-541	8	24	experiments	experiment	NOUN
finefocus-541	8	25	to	to	PART
finefocus-541	8	26	show	show	VERB
finefocus-541	8	27	that	that	SCONJ
finefocus-541	8	28	the	the	DET
finefocus-541	8	29	surviving	survive	VERB
finefocus-541	8	30	bacteria	bacteria	NOUN
finefocus-541	8	31	are	be	AUX
finefocus-541	8	32	neither	neither	CCONJ
finefocus-541	8	33	antibiotic	antibiotic	ADJ
finefocus-541	8	34	resistant	resistant	ADJ
finefocus-541	8	35	nor	nor	CCONJ
finefocus-541	8	36	persister	persister	NOUN
finefocus-541	8	37	cells	cell	NOUN
finefocus-541	8	38	.	.	PUNCT
finefocus-541	9	1	instead	instead	ADV
finefocus-541	9	2	,	,	PUNCT
finefocus-541	9	3	they	they	PRON
finefocus-541	9	4	are	be	AUX
finefocus-541	9	5	still	still	ADV
finefocus-541	9	6	susceptible	susceptible	ADJ
finefocus-541	9	7	to	to	ADP
finefocus-541	9	8	high	high	ADJ
finefocus-541	9	9	doses	dose	NOUN
finefocus-541	9	10	(	(	PUNCT
finefocus-541	9	11	200	200	NUM
finefocus-541	9	12	µg	µg	NOUN
finefocus-541	9	13	/	/	SYM
finefocus-541	9	14	ml	ml	NOUN
finefocus-541	9	15	)	)	PUNCT
finefocus-541	9	16	of	of	ADP
finefocus-541	9	17	the	the	DET
finefocus-541	9	18	antibiotic	antibiotic	NOUN
finefocus-541	9	19	over	over	ADP
finefocus-541	9	20	a	a	DET
finefocus-541	9	21	period	period	NOUN
finefocus-541	9	22	of	of	ADP
finefocus-541	9	23	48	48	NUM
finefocus-541	9	24	hours	hour	NOUN
finefocus-541	9	25	(	(	PUNCT
finefocus-541	9	26	p<0.001	p<0.001	PROPN
finefocus-541	9	27	)	)	PUNCT
finefocus-541	9	28	.	.	PUNCT
finefocus-541	10	1	we	we	PRON
finefocus-541	10	2	believe	believe	VERB
finefocus-541	10	3	the	the	DET
finefocus-541	10	4	bacteria	bacteria	NOUN
finefocus-541	10	5	survive	survive	VERB
finefocus-541	10	6	exposure	exposure	NOUN
finefocus-541	10	7	to	to	ADP
finefocus-541	10	8	the	the	DET
finefocus-541	10	9	antibiotic	antibiotic	NOUN
finefocus-541	10	10	during	during	ADP
finefocus-541	10	11	the	the	DET
finefocus-541	10	12	macrophage	macrophage	ADJ
finefocus-541	10	13	infection	infection	NOUN
finefocus-541	10	14	because	because	SCONJ
finefocus-541	10	15	of	of	ADP
finefocus-541	10	16	their	their	PRON
finefocus-541	10	17	ability	ability	NOUN
finefocus-541	10	18	to	to	PART
finefocus-541	10	19	move	move	VERB
finefocus-541	10	20	between	between	ADP
finefocus-541	10	21	intracellular	intracellular	ADJ
finefocus-541	10	22	and	and	CCONJ
finefocus-541	10	23	extracellular	extracellular	ADJ
finefocus-541	10	24	compartments	compartment	NOUN
finefocus-541	10	25	,	,	PUNCT
finefocus-541	10	26	thus	thus	ADV
finefocus-541	10	27	avoiding	avoid	VERB
finefocus-541	10	28	the	the	DET
finefocus-541	10	29	antibiotic	antibiotic	NOUN
finefocus-541	10	30	and	and	CCONJ
finefocus-541	10	31	its	its	PRON
finefocus-541	10	32	deadly	deadly	ADJ
finefocus-541	10	33	effects	effect	NOUN
finefocus-541	10	34	.	.	PUNCT
finefocus-541	11	1	our	our	PRON
finefocus-541	11	2	results	result	NOUN
finefocus-541	11	3	provide	provide	VERB
finefocus-541	11	4	evidence	evidence	NOUN
finefocus-541	11	5	to	to	PART
finefocus-541	11	6	suggest	suggest	VERB
finefocus-541	11	7	that	that	SCONJ
finefocus-541	11	8	intracellular	intracellular	ADJ
finefocus-541	11	9	pathogens	pathogen	NOUN
finefocus-541	11	10	,	,	PUNCT
finefocus-541	11	11	through	through	ADP
finefocus-541	11	12	movement	movement	NOUN
finefocus-541	11	13	between	between	ADP
finefocus-541	11	14	intracellular	intracellular	ADJ
finefocus-541	11	15	and	and	CCONJ
finefocus-541	11	16	extracellular	extracellular	ADJ
finefocus-541	11	17	compartments	compartment	NOUN
finefocus-541	11	18	,	,	PUNCT
finefocus-541	11	19	may	may	AUX
finefocus-541	11	20	be	be	AUX
finefocus-541	11	21	protected	protect	VERB
finefocus-541	11	22	from	from	ADP
finefocus-541	11	23	the	the	DET
finefocus-541	11	24	effects	effect	NOUN
finefocus-541	11	25	of	of	ADP
finefocus-541	11	26	antibiotics	antibiotic	NOUN
finefocus-541	11	27	in	in	ADP
finefocus-541	11	28	similar	similar	ADJ
finefocus-541	11	29	macrophage	macrophage	ADJ
finefocus-541	11	30	infection	infection	NOUN
finefocus-541	11	31	models	model	NOUN
finefocus-541	11	32	.	.	PUNCT
finefocus-541	12	1	abstract	abstract	ADJ
finefocus-541	12	2	keywords	keyword	NOUN
finefocus-541	12	3	•	•	VERB
finefocus-541	12	4	persister	persister	NOUN
finefocus-541	12	5	cells	cell	NOUN
finefocus-541	12	6	•	•	PRON
finefocus-541	12	7	antibiotic	antibiotic	ADJ
finefocus-541	12	8	resistance	resistance	NOUN
finefocus-541	12	9	•	•	NOUN
finefocus-541	12	10	burkholderia	burkholderia	NOUN
finefocus-541	12	11	•	•	NOUN
finefocus-541	12	12	macrophages	macrophage	NOUN
finefocus-541	12	13	•	•	CCONJ
finefocus-541	12	14	intracellular	intracellular	ADJ
finefocus-541	12	15	bacteria	bacteria	NOUN
finefocus-541	12	16	introduction	introduction	NOUN
finefocus-541	12	17	burkholderia	burkholderia	NOUN
finefocus-541	12	18	pseudomallei	pseudomallei	NOUN
finefocus-541	12	19	is	be	AUX
finefocus-541	12	20	a	a	DET
finefocus-541	12	21	facultative	facultative	ADJ
finefocus-541	12	22	intracellular	intracellular	ADJ
finefocus-541	12	23	pathogen	pathogen	NOUN
finefocus-541	12	24	and	and	CCONJ
finefocus-541	12	25	the	the	DET
finefocus-541	12	26	etiological	etiological	ADJ
finefocus-541	12	27	agent	agent	NOUN
finefocus-541	12	28	of	of	ADP
finefocus-541	12	29	melioidosis	melioidosis	NOUN
finefocus-541	12	30	(	(	PUNCT
finefocus-541	12	31	1	1	NUM
finefocus-541	12	32	,	,	PUNCT
finefocus-541	12	33	13	13	NUM
finefocus-541	12	34	,	,	PUNCT
finefocus-541	12	35	14	14	NUM
finefocus-541	12	36	,	,	PUNCT
finefocus-541	12	37	19	19	NUM
finefocus-541	12	38	)	)	PUNCT
finefocus-541	12	39	.	.	PUNCT
finefocus-541	13	1	this	this	DET
finefocus-541	13	2	disease	disease	NOUN
finefocus-541	13	3	is	be	AUX
finefocus-541	13	4	endemic	endemic	ADJ
finefocus-541	13	5	in	in	ADP
finefocus-541	13	6	regions	region	NOUN
finefocus-541	13	7	such	such	ADJ
finefocus-541	13	8	as	as	ADP
finefocus-541	13	9	southeast	southeast	PROPN
finefocus-541	13	10	asia	asia	PROPN
finefocus-541	13	11	and	and	CCONJ
finefocus-541	13	12	northern	northern	PROPN
finefocus-541	13	13	australia	australia	PROPN
finefocus-541	13	14	and	and	CCONJ
finefocus-541	13	15	causes	cause	VERB
finefocus-541	13	16	potentially	potentially	ADV
finefocus-541	13	17	fatal	fatal	ADJ
finefocus-541	13	18	infections	infection	NOUN
finefocus-541	13	19	that	that	PRON
finefocus-541	13	20	can	can	AUX
finefocus-541	13	21	present	present	VERB
finefocus-541	13	22	as	as	ADP
finefocus-541	13	23	pneumonia	pneumonia	NOUN
finefocus-541	13	24	or	or	CCONJ
finefocus-541	13	25	septicemia	septicemia	NOUN
finefocus-541	13	26	(	(	PUNCT
finefocus-541	13	27	16	16	NUM
finefocus-541	13	28	)	)	PUNCT
finefocus-541	13	29	.	.	PUNCT
finefocus-541	14	1	b.	b.	PROPN
finefocus-541	14	2	pseudomallei	pseudomallei	NOUN
finefocus-541	14	3	is	be	AUX
finefocus-541	14	4	inherently	inherently	ADV
finefocus-541	14	5	highly	highly	ADV
finefocus-541	14	6	antibiotic	antibiotic	ADJ
finefocus-541	14	7	resistant	resistant	ADJ
finefocus-541	14	8	and	and	CCONJ
finefocus-541	14	9	due	due	ADP
finefocus-541	14	10	to	to	ADP
finefocus-541	14	11	the	the	DET
finefocus-541	14	12	swift	swift	ADJ
finefocus-541	14	13	progression	progression	NOUN
finefocus-541	14	14	and	and	CCONJ
finefocus-541	14	15	deadly	deadly	ADJ
finefocus-541	14	16	nature	nature	NOUN
finefocus-541	14	17	of	of	ADP
finefocus-541	14	18	the	the	DET
finefocus-541	14	19	disease	disease	NOUN
finefocus-541	14	20	it	it	PRON
finefocus-541	14	21	causes	cause	VERB
finefocus-541	14	22	,	,	PUNCT
finefocus-541	14	23	is	be	AUX
finefocus-541	14	24	considered	consider	VERB
finefocus-541	14	25	to	to	PART
finefocus-541	14	26	be	be	AUX
finefocus-541	14	27	a	a	DET
finefocus-541	14	28	bioterrorism	bioterrorism	NOUN
finefocus-541	14	29	threat	threat	NOUN
finefocus-541	14	30	(	(	PUNCT
finefocus-541	14	31	17	17	NUM
finefocus-541	14	32	)	)	PUNCT
finefocus-541	14	33	.	.	PUNCT
finefocus-541	15	1	there	there	PRON
finefocus-541	15	2	is	be	VERB
finefocus-541	15	3	no	no	DET
finefocus-541	15	4	current	current	ADJ
finefocus-541	15	5	vaccine	vaccine	NOUN
finefocus-541	15	6	to	to	PART
finefocus-541	15	7	prevent	prevent	VERB
finefocus-541	15	8	this	this	DET
finefocus-541	15	9	corresponding	corresponding	ADJ
finefocus-541	15	10	author	author	NOUN
finefocus-541	15	11	kara	kara	PROPN
finefocus-541	15	12	mosovsky	mosovsky	PROPN
finefocus-541	15	13	mosovskyk@moravian.edu	mosovskyk@moravian.edu	PROPN
finefocus-541	16	1	119pathogens	119pathogens	PROPN
finefocus-541	16	2	&	&	CCONJ
finefocus-541	16	3	antimicrobial	antimicrobial	ADJ
finefocus-541	16	4	factors	factor	NOUN
finefocus-541	16	5	•	•	ADP
finefocus-541	16	6	deadly	deadly	ADJ
finefocus-541	16	7	disease	disease	NOUN
finefocus-541	16	8	,	,	PUNCT
finefocus-541	16	9	and	and	CCONJ
finefocus-541	16	10	most	most	ADJ
finefocus-541	16	11	of	of	ADP
finefocus-541	16	12	the	the	DET
finefocus-541	16	13	treatments	treatment	NOUN
finefocus-541	16	14	for	for	ADP
finefocus-541	16	15	melioidosis	melioidosis	NOUN
finefocus-541	16	16	involve	involve	VERB
finefocus-541	16	17	several	several	ADJ
finefocus-541	16	18	weeks	week	NOUN
finefocus-541	16	19	of	of	ADP
finefocus-541	16	20	intravenous	intravenous	ADJ
finefocus-541	16	21	antibiotics	antibiotic	NOUN
finefocus-541	16	22	,	,	PUNCT
finefocus-541	16	23	often	often	ADV
finefocus-541	16	24	with	with	ADP
finefocus-541	16	25	the	the	DET
finefocus-541	16	26	antibiotic	antibiotic	ADJ
finefocus-541	16	27	ceftazidime	ceftazidime	NOUN
finefocus-541	16	28	(	(	PUNCT
finefocus-541	16	29	13	13	NUM
finefocus-541	16	30	,	,	PUNCT
finefocus-541	16	31	19	19	NUM
finefocus-541	16	32	)	)	PUNCT
finefocus-541	16	33	.	.	PUNCT
finefocus-541	17	1	however	however	ADV
finefocus-541	17	2	,	,	PUNCT
finefocus-541	17	3	even	even	ADV
finefocus-541	17	4	with	with	ADP
finefocus-541	17	5	antibiotic	antibiotic	ADJ
finefocus-541	17	6	treatment	treatment	NOUN
finefocus-541	17	7	,	,	PUNCT
finefocus-541	17	8	mortality	mortality	NOUN
finefocus-541	17	9	rates	rate	NOUN
finefocus-541	17	10	still	still	ADV
finefocus-541	17	11	range	range	VERB
finefocus-541	17	12	from	from	ADP
finefocus-541	17	13	20	20	NUM
finefocus-541	17	14	-	-	SYM
finefocus-541	17	15	50	50	NUM
finefocus-541	17	16	%	%	NOUN
finefocus-541	17	17	,	,	PUNCT
finefocus-541	17	18	and	and	CCONJ
finefocus-541	17	19	as	as	ADV
finefocus-541	17	20	many	many	ADJ
finefocus-541	17	21	as	as	ADP
finefocus-541	17	22	10	10	NUM
finefocus-541	17	23	%	%	NOUN
finefocus-541	17	24	of	of	ADP
finefocus-541	17	25	individuals	individual	NOUN
finefocus-541	17	26	experience	experience	VERB
finefocus-541	17	27	recurrent	recurrent	ADJ
finefocus-541	17	28	infections	infection	NOUN
finefocus-541	17	29	,	,	PUNCT
finefocus-541	17	30	usually	usually	ADV
finefocus-541	17	31	due	due	ADJ
finefocus-541	17	32	to	to	PART
finefocus-541	17	33	relapse	relapse	VERB
finefocus-541	17	34	of	of	ADP
finefocus-541	17	35	the	the	DET
finefocus-541	17	36	original	original	ADJ
finefocus-541	17	37	infection	infection	NOUN
finefocus-541	17	38	(	(	PUNCT
finefocus-541	17	39	17	17	NUM
finefocus-541	17	40	)	)	PUNCT
finefocus-541	17	41	.	.	PUNCT
finefocus-541	18	1	the	the	DET
finefocus-541	18	2	high	high	ADJ
finefocus-541	18	3	rate	rate	NOUN
finefocus-541	18	4	of	of	ADP
finefocus-541	18	5	relapse	relapse	NOUN
finefocus-541	18	6	infections	infection	NOUN
finefocus-541	18	7	would	would	AUX
finefocus-541	18	8	suggest	suggest	VERB
finefocus-541	18	9	that	that	SCONJ
finefocus-541	18	10	complete	complete	ADJ
finefocus-541	18	11	elimination	elimination	NOUN
finefocus-541	18	12	of	of	ADP
finefocus-541	18	13	the	the	DET
finefocus-541	18	14	pathogen	pathogen	NOUN
finefocus-541	18	15	is	be	AUX
finefocus-541	18	16	important	important	ADJ
finefocus-541	18	17	for	for	ADP
finefocus-541	18	18	a	a	DET
finefocus-541	18	19	patient	patient	NOUN
finefocus-541	18	20	’s	’s	PART
finefocus-541	18	21	full	full	ADJ
finefocus-541	18	22	recovery	recovery	NOUN
finefocus-541	18	23	.	.	PUNCT
finefocus-541	19	1	considering	consider	VERB
finefocus-541	19	2	the	the	DET
finefocus-541	19	3	challenges	challenge	NOUN
finefocus-541	19	4	of	of	ADP
finefocus-541	19	5	treating	treat	VERB
finefocus-541	19	6	melioidosis	melioidosis	NOUN
finefocus-541	19	7	,	,	PUNCT
finefocus-541	19	8	it	it	PRON
finefocus-541	19	9	is	be	AUX
finefocus-541	19	10	essential	essential	ADJ
finefocus-541	19	11	to	to	PART
finefocus-541	19	12	develop	develop	VERB
finefocus-541	19	13	new	new	ADJ
finefocus-541	19	14	therapies	therapy	NOUN
finefocus-541	19	15	,	,	PUNCT
finefocus-541	19	16	which	which	PRON
finefocus-541	19	17	could	could	AUX
finefocus-541	19	18	potentially	potentially	ADV
finefocus-541	19	19	decrease	decrease	VERB
finefocus-541	19	20	the	the	DET
finefocus-541	19	21	burden	burden	NOUN
finefocus-541	19	22	of	of	ADP
finefocus-541	19	23	disease	disease	NOUN
finefocus-541	19	24	.	.	PUNCT
finefocus-541	20	1	a	a	DET
finefocus-541	20	2	series	series	NOUN
finefocus-541	20	3	of	of	ADP
finefocus-541	20	4	previous	previous	ADJ
finefocus-541	20	5	studies	study	NOUN
finefocus-541	20	6	have	have	AUX
finefocus-541	20	7	investigated	investigate	VERB
finefocus-541	20	8	one	one	NUM
finefocus-541	20	9	alternative	alternative	ADJ
finefocus-541	20	10	treatment	treatment	NOUN
finefocus-541	20	11	option	option	NOUN
finefocus-541	20	12	in	in	ADP
finefocus-541	20	13	a	a	DET
finefocus-541	20	14	macrophage	macrophage	ADJ
finefocus-541	20	15	infection	infection	NOUN
finefocus-541	20	16	model	model	NOUN
finefocus-541	20	17	using	use	VERB
finefocus-541	20	18	both	both	CCONJ
finefocus-541	20	19	the	the	DET
finefocus-541	20	20	virulent	virulent	PROPN
finefocus-541	20	21	b.	b.	PROPN
finefocus-541	20	22	pseudomallei	pseudomallei	NOUN
finefocus-541	20	23	and	and	CCONJ
finefocus-541	20	24	also	also	ADV
finefocus-541	20	25	the	the	DET
finefocus-541	20	26	closely	closely	ADV
finefocus-541	20	27	related	relate	VERB
finefocus-541	20	28	and	and	CCONJ
finefocus-541	20	29	avirulent	avirulent	NOUN
finefocus-541	20	30	organism	organism	NOUN
finefocus-541	20	31	burkholderia	burkholderia	PROPN
finefocus-541	20	32	thailandensis	thailandensis	NOUN
finefocus-541	20	33	.	.	PUNCT
finefocus-541	21	1	these	these	DET
finefocus-541	21	2	studies	study	NOUN
finefocus-541	21	3	show	show	VERB
finefocus-541	21	4	the	the	DET
finefocus-541	21	5	ability	ability	NOUN
finefocus-541	21	6	of	of	ADP
finefocus-541	21	7	the	the	DET
finefocus-541	21	8	antibiotic	antibiotic	ADJ
finefocus-541	21	9	ceftazidime	ceftazidime	NOUN
finefocus-541	21	10	to	to	PART
finefocus-541	21	11	interact	interact	VERB
finefocus-541	21	12	with	with	ADP
finefocus-541	21	13	the	the	DET
finefocus-541	21	14	macrophage	macrophage	ADJ
finefocus-541	21	15	activator	activator	NOUN
finefocus-541	21	16	,	,	PUNCT
finefocus-541	21	17	interferon	interferon	ADJ
finefocus-541	21	18	-	-	PUNCT
finefocus-541	21	19	gamma	gamma	NOUN
finefocus-541	21	20	(	(	PUNCT
finefocus-541	21	21	ifn	ifn	PROPN
finefocus-541	21	22	-	-	PUNCT
finefocus-541	21	23	γ	γ	NOUN
finefocus-541	21	24	)	)	PUNCT
finefocus-541	21	25	,	,	PUNCT
finefocus-541	21	26	to	to	PART
finefocus-541	21	27	synergistically	synergistically	ADV
finefocus-541	21	28	reduce	reduce	VERB
finefocus-541	21	29	the	the	DET
finefocus-541	21	30	bacterial	bacterial	ADJ
finefocus-541	21	31	burden	burden	NOUN
finefocus-541	21	32	both	both	PRON
finefocus-541	21	33	inside	inside	ADP
finefocus-541	21	34	the	the	DET
finefocus-541	21	35	infected	infected	ADJ
finefocus-541	21	36	macrophages	macrophage	NOUN
finefocus-541	21	37	(	(	PUNCT
finefocus-541	21	38	intracellular	intracellular	ADJ
finefocus-541	21	39	compartment	compartment	NOUN
finefocus-541	21	40	)	)	PUNCT
finefocus-541	21	41	and	and	CCONJ
finefocus-541	21	42	outside	outside	ADP
finefocus-541	21	43	of	of	ADP
finefocus-541	21	44	the	the	DET
finefocus-541	21	45	infected	infected	ADJ
finefocus-541	21	46	macrophages	macrophage	NOUN
finefocus-541	21	47	(	(	PUNCT
finefocus-541	21	48	extracellular	extracellular	ADJ
finefocus-541	21	49	compartment	compartment	NOUN
finefocus-541	21	50	)	)	PUNCT
finefocus-541	21	51	(	(	PUNCT
finefocus-541	21	52	10	10	NUM
finefocus-541	21	53	,	,	PUNCT
finefocus-541	21	54	12	12	NUM
finefocus-541	21	55	)	)	PUNCT
finefocus-541	21	56	.	.	PUNCT
finefocus-541	22	1	what	what	PRON
finefocus-541	22	2	was	be	AUX
finefocus-541	22	3	surprising	surprising	ADJ
finefocus-541	22	4	from	from	ADP
finefocus-541	22	5	this	this	DET
finefocus-541	22	6	study	study	NOUN
finefocus-541	22	7	was	be	AUX
finefocus-541	22	8	that	that	SCONJ
finefocus-541	22	9	the	the	DET
finefocus-541	22	10	infected	infected	ADJ
finefocus-541	22	11	macrophages	macrophage	NOUN
finefocus-541	22	12	treated	treat	VERB
finefocus-541	22	13	with	with	ADP
finefocus-541	22	14	antibiotic	antibiotic	ADJ
finefocus-541	22	15	alone	alone	ADV
finefocus-541	22	16	still	still	ADV
finefocus-541	22	17	harbored	harbor	VERB
finefocus-541	22	18	a	a	DET
finefocus-541	22	19	significant	significant	ADJ
finefocus-541	22	20	amount	amount	NOUN
finefocus-541	22	21	of	of	ADP
finefocus-541	22	22	extracellular	extracellular	ADJ
finefocus-541	22	23	bacteria	bacteria	NOUN
finefocus-541	22	24	,	,	PUNCT
finefocus-541	22	25	even	even	ADV
finefocus-541	22	26	when	when	SCONJ
finefocus-541	22	27	the	the	DET
finefocus-541	22	28	antibiotic	antibiotic	ADJ
finefocus-541	22	29	concentration	concentration	NOUN
finefocus-541	22	30	was	be	AUX
finefocus-541	22	31	approximately	approximately	ADV
finefocus-541	22	32	five	five	NUM
finefocus-541	22	33	times	time	NOUN
finefocus-541	22	34	the	the	DET
finefocus-541	22	35	minimum	minimum	ADJ
finefocus-541	22	36	inhibitory	inhibitory	ADJ
finefocus-541	22	37	concentration	concentration	NOUN
finefocus-541	22	38	(	(	PUNCT
finefocus-541	22	39	mic	mic	ADJ
finefocus-541	22	40	)	)	PUNCT
finefocus-541	22	41	(	(	PUNCT
finefocus-541	22	42	10	10	NUM
finefocus-541	22	43	)	)	PUNCT
finefocus-541	22	44	.	.	PUNCT
finefocus-541	23	1	since	since	SCONJ
finefocus-541	23	2	current	current	ADJ
finefocus-541	23	3	melioidosis	melioidosis	NOUN
finefocus-541	23	4	treatment	treatment	NOUN
finefocus-541	23	5	relies	rely	VERB
finefocus-541	23	6	almost	almost	ADV
finefocus-541	23	7	exclusively	exclusively	ADV
finefocus-541	23	8	on	on	ADP
finefocus-541	23	9	antibiotics	antibiotic	NOUN
finefocus-541	23	10	alone	alone	ADV
finefocus-541	23	11	,	,	PUNCT
finefocus-541	23	12	this	this	DET
finefocus-541	23	13	result	result	NOUN
finefocus-541	23	14	was	be	AUX
finefocus-541	23	15	disconcerting	disconcert	VERB
finefocus-541	23	16	and	and	CCONJ
finefocus-541	23	17	warranted	warrant	VERB
finefocus-541	23	18	further	further	ADJ
finefocus-541	23	19	investigation	investigation	NOUN
finefocus-541	23	20	.	.	PUNCT
finefocus-541	24	1	such	such	ADJ
finefocus-541	24	2	remaining	remain	VERB
finefocus-541	24	3	bacteria	bacteria	NOUN
finefocus-541	24	4	may	may	AUX
finefocus-541	24	5	still	still	ADV
finefocus-541	24	6	pose	pose	VERB
finefocus-541	24	7	a	a	DET
finefocus-541	24	8	significant	significant	ADJ
finefocus-541	24	9	threat	threat	NOUN
finefocus-541	24	10	in	in	ADP
finefocus-541	24	11	a	a	DET
finefocus-541	24	12	host	host	NOUN
finefocus-541	24	13	and	and	CCONJ
finefocus-541	24	14	could	could	AUX
finefocus-541	24	15	explain	explain	VERB
finefocus-541	24	16	why	why	SCONJ
finefocus-541	24	17	patients	patient	NOUN
finefocus-541	24	18	with	with	ADP
finefocus-541	24	19	melioidosis	melioidosis	NOUN
finefocus-541	24	20	often	often	ADV
finefocus-541	24	21	develop	develop	VERB
finefocus-541	24	22	recurrent	recurrent	ADJ
finefocus-541	24	23	infections	infection	NOUN
finefocus-541	24	24	due	due	ADJ
finefocus-541	24	25	to	to	PART
finefocus-541	24	26	relapse	relapse	NOUN
finefocus-541	24	27	of	of	ADP
finefocus-541	24	28	the	the	DET
finefocus-541	24	29	original	original	ADJ
finefocus-541	24	30	infection	infection	NOUN
finefocus-541	24	31	.	.	PUNCT
finefocus-541	25	1	from	from	ADP
finefocus-541	25	2	these	these	DET
finefocus-541	25	3	previous	previous	ADJ
finefocus-541	25	4	studies	study	NOUN
finefocus-541	25	5	we	we	PRON
finefocus-541	25	6	developed	develop	VERB
finefocus-541	25	7	a	a	DET
finefocus-541	25	8	new	new	ADJ
finefocus-541	25	9	research	research	NOUN
finefocus-541	25	10	question	question	NOUN
finefocus-541	25	11	regarding	regard	VERB
finefocus-541	25	12	these	these	DET
finefocus-541	25	13	surviving	survive	VERB
finefocus-541	25	14	extracellular	extracellular	ADJ
finefocus-541	25	15	bacteria	bacteria	NOUN
finefocus-541	25	16	:	:	PUNCT
finefocus-541	25	17	are	be	AUX
finefocus-541	25	18	the	the	DET
finefocus-541	25	19	remaining	remain	VERB
finefocus-541	25	20	extracellular	extracellular	ADJ
finefocus-541	25	21	bacteria	bacteria	NOUN
finefocus-541	25	22	still	still	ADV
finefocus-541	25	23	sensitive	sensitive	ADJ
finefocus-541	25	24	to	to	ADP
finefocus-541	25	25	the	the	DET
finefocus-541	25	26	antibiotic	antibiotic	NOUN
finefocus-541	25	27	or	or	CCONJ
finefocus-541	25	28	have	have	AUX
finefocus-541	25	29	they	they	PRON
finefocus-541	25	30	become	become	VERB
finefocus-541	25	31	antibiotic	antibiotic	ADJ
finefocus-541	25	32	tolerant	tolerant	ADJ
finefocus-541	25	33	?	?	PUNCT
finefocus-541	26	1	this	this	DET
finefocus-541	26	2	question	question	NOUN
finefocus-541	26	3	was	be	AUX
finefocus-541	26	4	the	the	DET
finefocus-541	26	5	focal	focal	ADJ
finefocus-541	26	6	point	point	NOUN
finefocus-541	26	7	of	of	ADP
finefocus-541	26	8	our	our	PRON
finefocus-541	26	9	study	study	NOUN
finefocus-541	26	10	.	.	PUNCT
finefocus-541	27	1	there	there	PRON
finefocus-541	27	2	are	be	VERB
finefocus-541	27	3	two	two	NUM
finefocus-541	27	4	main	main	ADJ
finefocus-541	27	5	types	type	NOUN
finefocus-541	27	6	of	of	ADP
finefocus-541	27	7	antibiotic	antibiotic	ADJ
finefocus-541	27	8	tolerant	tolerant	ADJ
finefocus-541	27	9	bacteria	bacteria	NOUN
finefocus-541	27	10	.	.	PUNCT
finefocus-541	28	1	classical	classical	ADJ
finefocus-541	28	2	antibiotic	antibiotic	ADJ
finefocus-541	28	3	resistance	resistance	NOUN
finefocus-541	28	4	is	be	AUX
finefocus-541	28	5	a	a	DET
finefocus-541	28	6	permanent	permanent	ADJ
finefocus-541	28	7	and	and	CCONJ
finefocus-541	28	8	heritable	heritable	ADJ
finefocus-541	28	9	tolerance	tolerance	NOUN
finefocus-541	28	10	to	to	ADP
finefocus-541	28	11	antibiotics	antibiotic	NOUN
finefocus-541	28	12	,	,	PUNCT
finefocus-541	28	13	while	while	SCONJ
finefocus-541	28	14	persistence	persistence	NOUN
finefocus-541	28	15	is	be	AUX
finefocus-541	28	16	a	a	DET
finefocus-541	28	17	temporary	temporary	ADJ
finefocus-541	28	18	and	and	CCONJ
finefocus-541	28	19	non	non	ADJ
finefocus-541	28	20	-	-	ADJ
finefocus-541	28	21	heritable	heritable	ADJ
finefocus-541	28	22	tolerance	tolerance	NOUN
finefocus-541	28	23	(	(	PUNCT
finefocus-541	28	24	8)	8)	NUM
finefocus-541	28	25	.	.	PUNCT
finefocus-541	29	1	persister	persister	NOUN
finefocus-541	29	2	cells	cell	NOUN
finefocus-541	29	3	are	be	AUX
finefocus-541	29	4	thought	think	VERB
finefocus-541	29	5	to	to	PART
finefocus-541	29	6	be	be	AUX
finefocus-541	29	7	present	present	ADJ
finefocus-541	29	8	as	as	ADP
finefocus-541	29	9	a	a	DET
finefocus-541	29	10	small	small	ADJ
finefocus-541	29	11	subpopulation	subpopulation	NOUN
finefocus-541	29	12	in	in	ADP
finefocus-541	29	13	any	any	DET
finefocus-541	29	14	large	large	ADJ
finefocus-541	29	15	bacterial	bacterial	ADJ
finefocus-541	29	16	population	population	NOUN
finefocus-541	29	17	and	and	CCONJ
finefocus-541	29	18	are	be	AUX
finefocus-541	29	19	characterized	characterize	VERB
finefocus-541	29	20	as	as	ADP
finefocus-541	29	21	slow	slow	ADJ
finefocus-541	29	22	or	or	CCONJ
finefocus-541	29	23	non	non	ADJ
finefocus-541	29	24	-	-	ADJ
finefocus-541	29	25	growing	growing	ADJ
finefocus-541	29	26	,	,	PUNCT
finefocus-541	29	27	dormant	dormant	ADJ
finefocus-541	29	28	,	,	PUNCT
finefocus-541	29	29	bacterial	bacterial	ADJ
finefocus-541	29	30	cells	cell	NOUN
finefocus-541	29	31	that	that	PRON
finefocus-541	29	32	are	be	AUX
finefocus-541	29	33	temporarily	temporarily	ADV
finefocus-541	29	34	tolerant	tolerant	ADJ
finefocus-541	29	35	to	to	ADP
finefocus-541	29	36	antibiotics	antibiotic	NOUN
finefocus-541	29	37	due	due	ADP
finefocus-541	29	38	to	to	ADP
finefocus-541	29	39	their	their	PRON
finefocus-541	29	40	lack	lack	NOUN
finefocus-541	29	41	of	of	ADP
finefocus-541	29	42	replication	replication	NOUN
finefocus-541	29	43	(	(	PUNCT
finefocus-541	29	44	3	3	NUM
finefocus-541	29	45	-	-	SYM
finefocus-541	29	46	5	5	NUM
finefocus-541	29	47	,	,	PUNCT
finefocus-541	29	48	8	8	NUM
finefocus-541	29	49	,	,	PUNCT
finefocus-541	29	50	9	9	NUM
finefocus-541	29	51	)	)	PUNCT
finefocus-541	29	52	.	.	PUNCT
finefocus-541	30	1	additionally	additionally	ADV
finefocus-541	30	2	,	,	PUNCT
finefocus-541	30	3	when	when	SCONJ
finefocus-541	30	4	the	the	DET
finefocus-541	30	5	antibiotic	antibiotic	NOUN
finefocus-541	30	6	is	be	AUX
finefocus-541	30	7	removed	remove	VERB
finefocus-541	30	8	and	and	CCONJ
finefocus-541	30	9	persister	persister	NOUN
finefocus-541	30	10	cells	cell	NOUN
finefocus-541	30	11	resume	resume	VERB
finefocus-541	30	12	replication	replication	NOUN
finefocus-541	30	13	,	,	PUNCT
finefocus-541	30	14	most	most	ADJ
finefocus-541	30	15	of	of	ADP
finefocus-541	30	16	the	the	DET
finefocus-541	30	17	progeny	progeny	NOUN
finefocus-541	30	18	of	of	ADP
finefocus-541	30	19	persister	persister	NOUN
finefocus-541	30	20	cells	cell	NOUN
finefocus-541	30	21	are	be	AUX
finefocus-541	30	22	susceptible	susceptible	ADJ
finefocus-541	30	23	to	to	ADP
finefocus-541	30	24	the	the	DET
finefocus-541	30	25	antibiotic	antibiotic	NOUN
finefocus-541	30	26	,	,	PUNCT
finefocus-541	30	27	a	a	DET
finefocus-541	30	28	trait	trait	NOUN
finefocus-541	30	29	that	that	PRON
finefocus-541	30	30	helps	helps	AUX
finefocus-541	30	31	distinguish	distinguish	VERB
finefocus-541	30	32	them	they	PRON
finefocus-541	30	33	from	from	ADP
finefocus-541	30	34	classically	classically	ADV
finefocus-541	30	35	resistant	resistant	ADJ
finefocus-541	30	36	bacteria	bacteria	NOUN
finefocus-541	30	37	(	(	PUNCT
finefocus-541	30	38	7	7	NUM
finefocus-541	30	39	,	,	PUNCT
finefocus-541	30	40	8)	8)	NUM
finefocus-541	30	41	.	.	PUNCT
finefocus-541	31	1	while	while	SCONJ
finefocus-541	31	2	the	the	DET
finefocus-541	31	3	rate	rate	NOUN
finefocus-541	31	4	of	of	ADP
finefocus-541	31	5	persister	persister	ADJ
finefocus-541	31	6	cell	cell	NOUN
finefocus-541	31	7	formation	formation	NOUN
finefocus-541	31	8	is	be	AUX
finefocus-541	31	9	typically	typically	ADV
finefocus-541	31	10	less	less	ADJ
finefocus-541	31	11	than	than	ADP
finefocus-541	31	12	1	1	NUM
finefocus-541	31	13	%	%	NOUN
finefocus-541	31	14	for	for	ADP
finefocus-541	31	15	many	many	ADJ
finefocus-541	31	16	pathogens	pathogen	NOUN
finefocus-541	31	17	,	,	PUNCT
finefocus-541	31	18	studies	study	NOUN
finefocus-541	31	19	on	on	ADP
finefocus-541	31	20	burkholderia	burkholderia	NOUN
finefocus-541	31	21	persisters	persister	NOUN
finefocus-541	31	22	have	have	AUX
finefocus-541	31	23	shown	show	VERB
finefocus-541	31	24	that	that	SCONJ
finefocus-541	31	25	cultures	culture	NOUN
finefocus-541	31	26	of	of	ADP
finefocus-541	31	27	b.	b.	PROPN
finefocus-541	31	28	pseudomallei	pseudomallei	NOUN
finefocus-541	31	29	and	and	CCONJ
finefocus-541	31	30	b.	b.	PROPN
finefocus-541	31	31	thailandensis	thailandensis	NOUN
finefocus-541	31	32	can	can	AUX
finefocus-541	31	33	harbor	harbor	VERB
finefocus-541	31	34	around	around	ADP
finefocus-541	31	35	ten	ten	NUM
finefocus-541	31	36	times	time	NOUN
finefocus-541	31	37	higher	high	ADJ
finefocus-541	31	38	frequencies	frequency	NOUN
finefocus-541	31	39	of	of	ADP
finefocus-541	31	40	persister	persister	NOUN
finefocus-541	31	41	cells	cell	NOUN
finefocus-541	31	42	compared	compare	VERB
finefocus-541	31	43	to	to	ADP
finefocus-541	31	44	other	other	ADJ
finefocus-541	31	45	bacteria	bacteria	NOUN
finefocus-541	31	46	such	such	ADJ
finefocus-541	31	47	as	as	ADP
finefocus-541	31	48	escherichia	escherichia	NOUN
finefocus-541	31	49	coli	coli	NOUN
finefocus-541	31	50	,	,	PUNCT
finefocus-541	31	51	staphylococcus	staphylococcus	NOUN
finefocus-541	31	52	aureus	aureus	NOUN
finefocus-541	31	53	,	,	PUNCT
finefocus-541	31	54	and	and	CCONJ
finefocus-541	31	55	pseudomonas	pseudomonas	PROPN
finefocus-541	31	56	aeruginosa	aeruginosa	NOUN
finefocus-541	31	57	(	(	PUNCT
finefocus-541	31	58	2	2	NUM
finefocus-541	31	59	,	,	PUNCT
finefocus-541	31	60	6	6	NUM
finefocus-541	31	61	,	,	PUNCT
finefocus-541	31	62	11	11	NUM
finefocus-541	31	63	,	,	PUNCT
finefocus-541	31	64	18	18	NUM
finefocus-541	31	65	)	)	PUNCT
finefocus-541	31	66	.	.	PUNCT
finefocus-541	32	1	we	we	PRON
finefocus-541	32	2	therefore	therefore	ADV
finefocus-541	32	3	had	have	VERB
finefocus-541	32	4	reason	reason	NOUN
finefocus-541	32	5	to	to	PART
finefocus-541	32	6	hypothesize	hypothesize	VERB
finefocus-541	32	7	that	that	SCONJ
finefocus-541	32	8	persister	persister	NOUN
finefocus-541	32	9	cells	cell	NOUN
finefocus-541	32	10	may	may	AUX
finefocus-541	32	11	compose	compose	VERB
finefocus-541	32	12	some	some	PRON
finefocus-541	32	13	or	or	CCONJ
finefocus-541	32	14	all	all	PRON
finefocus-541	32	15	of	of	ADP
finefocus-541	32	16	the	the	DET
finefocus-541	32	17	remaining	remain	VERB
finefocus-541	32	18	population	population	NOUN
finefocus-541	32	19	of	of	ADP
finefocus-541	32	20	bacteria	bacteria	NOUN
finefocus-541	32	21	that	that	PRON
finefocus-541	32	22	had	have	AUX
finefocus-541	32	23	survived	survive	VERB
finefocus-541	32	24	antibiotic	antibiotic	ADJ
finefocus-541	32	25	treatment	treatment	NOUN
finefocus-541	32	26	120•	120•	NUM
finefocus-541	32	27	fine	fine	ADJ
finefocus-541	32	28	focus	focus	NOUN
finefocus-541	32	29	,	,	PUNCT
finefocus-541	32	30	vol	vol	NOUN
finefocus-541	32	31	.	.	PUNCT
finefocus-541	32	32	4(1	4(1	NOUN
finefocus-541	32	33	)	)	PUNCT
finefocus-541	32	34	during	during	ADP
finefocus-541	32	35	the	the	DET
finefocus-541	32	36	macrophage	macrophage	ADJ
finefocus-541	32	37	infection	infection	NOUN
finefocus-541	32	38	.	.	PUNCT
finefocus-541	33	1	the	the	DET
finefocus-541	33	2	aim	aim	NOUN
finefocus-541	33	3	of	of	ADP
finefocus-541	33	4	the	the	DET
finefocus-541	33	5	current	current	ADJ
finefocus-541	33	6	study	study	NOUN
finefocus-541	33	7	was	be	AUX
finefocus-541	33	8	to	to	PART
finefocus-541	33	9	determine	determine	VERB
finefocus-541	33	10	if	if	SCONJ
finefocus-541	33	11	the	the	DET
finefocus-541	33	12	remaining	remain	VERB
finefocus-541	33	13	extracellular	extracellular	ADJ
finefocus-541	33	14	bacteria	bacteria	NOUN
finefocus-541	33	15	were	be	AUX
finefocus-541	33	16	sensitive	sensitive	ADJ
finefocus-541	33	17	to	to	ADP
finefocus-541	33	18	antibiotics	antibiotic	NOUN
finefocus-541	33	19	,	,	PUNCT
finefocus-541	33	20	antibiotic	antibiotic	ADJ
finefocus-541	33	21	resistant	resistant	ADJ
finefocus-541	33	22	,	,	PUNCT
finefocus-541	33	23	or	or	CCONJ
finefocus-541	33	24	persister	persister	NOUN
finefocus-541	33	25	cells	cell	NOUN
finefocus-541	33	26	.	.	PUNCT
finefocus-541	34	1	by	by	ADP
finefocus-541	34	2	further	far	ADV
finefocus-541	34	3	characterizing	characterize	VERB
finefocus-541	34	4	the	the	DET
finefocus-541	34	5	surviving	survive	VERB
finefocus-541	34	6	extracellular	extracellular	ADJ
finefocus-541	34	7	bacteria	bacteria	NOUN
finefocus-541	34	8	,	,	PUNCT
finefocus-541	34	9	we	we	PRON
finefocus-541	34	10	would	would	AUX
finefocus-541	34	11	have	have	VERB
finefocus-541	34	12	the	the	DET
finefocus-541	34	13	opportunity	opportunity	NOUN
finefocus-541	34	14	to	to	PART
finefocus-541	34	15	gain	gain	VERB
finefocus-541	34	16	insights	insight	NOUN
finefocus-541	34	17	about	about	ADP
finefocus-541	34	18	the	the	DET
finefocus-541	34	19	treatment	treatment	NOUN
finefocus-541	34	20	of	of	ADP
finefocus-541	34	21	macrophages	macrophage	NOUN
finefocus-541	34	22	in	in	ADP
finefocus-541	34	23	our	our	PRON
finefocus-541	34	24	in	in	X
finefocus-541	34	25	vitro	vitro	X
finefocus-541	34	26	model	model	NOUN
finefocus-541	34	27	and	and	CCONJ
finefocus-541	34	28	help	help	VERB
finefocus-541	34	29	inform	inform	VERB
finefocus-541	34	30	future	future	ADJ
finefocus-541	34	31	treatment	treatment	NOUN
finefocus-541	34	32	options	option	NOUN
finefocus-541	34	33	against	against	ADP
finefocus-541	34	34	melioidosis	melioidosis	NOUN
finefocus-541	34	35	.	.	PUNCT
finefocus-541	35	1	materials	material	NOUN
finefocus-541	35	2	and	and	CCONJ
finefocus-541	35	3	methods	method	NOUN
finefocus-541	35	4	biochemicals	biochemical	NOUN
finefocus-541	35	5	ceftazidime	ceftazidime	NOUN
finefocus-541	35	6	hydrate	hydrate	NOUN
finefocus-541	35	7	was	be	AUX
finefocus-541	35	8	purchased	purchase	VERB
finefocus-541	35	9	from	from	ADP
finefocus-541	35	10	sigma	sigma	PROPN
finefocus-541	35	11	-	-	PUNCT
finefocus-541	35	12	aldrich	aldrich	PROPN
finefocus-541	35	13	(	(	PUNCT
finefocus-541	35	14	st	st	PROPN
finefocus-541	35	15	.	.	PROPN
finefocus-541	35	16	louis	louis	PROPN
finefocus-541	35	17	,	,	PUNCT
finefocus-541	35	18	mo	mo	PROPN
finefocus-541	35	19	)	)	PUNCT
finefocus-541	35	20	.	.	PUNCT
finefocus-541	36	1	recombinant	recombinant	ADJ
finefocus-541	36	2	murine	murine	ADJ
finefocus-541	36	3	ifn	ifn	PROPN
finefocus-541	36	4	-	-	PUNCT
finefocus-541	36	5	γ	γ	NOUN
finefocus-541	36	6	was	be	AUX
finefocus-541	36	7	purchased	purchase	VERB
finefocus-541	36	8	from	from	ADP
finefocus-541	36	9	peprotech	peprotech	NOUN
finefocus-541	36	10	(	(	PUNCT
finefocus-541	36	11	rocky	rocky	PROPN
finefocus-541	36	12	hill	hill	PROPN
finefocus-541	36	13	,	,	PUNCT
finefocus-541	36	14	nj	nj	PROPN
finefocus-541	36	15	)	)	PUNCT
finefocus-541	36	16	.	.	PUNCT
finefocus-541	37	1	kanamycin	kanamycin	PROPN
finefocus-541	37	2	monosulfate	monosulfate	NOUN
finefocus-541	37	3	was	be	AUX
finefocus-541	37	4	purchased	purchase	VERB
finefocus-541	37	5	from	from	ADP
finefocus-541	37	6	mp	mp	PROPN
finefocus-541	37	7	biomedicals	biomedical	NOUN
finefocus-541	37	8	,	,	PUNCT
finefocus-541	37	9	llc	llc	PROPN
finefocus-541	37	10	(	(	PUNCT
finefocus-541	37	11	santa	santa	PROPN
finefocus-541	37	12	ana	ana	PROPN
finefocus-541	37	13	,	,	PUNCT
finefocus-541	37	14	ca	ca	NOUN
finefocus-541	37	15	)	)	PUNCT
finefocus-541	37	16	,	,	PUNCT
finefocus-541	37	17	and	and	CCONJ
finefocus-541	37	18	luria	luria	PROPN
finefocus-541	37	19	bertani	bertani	NOUN
finefocus-541	37	20	(	(	PUNCT
finefocus-541	37	21	lb	lb	NOUN
finefocus-541	37	22	)	)	PUNCT
finefocus-541	37	23	broth	broth	NOUN
finefocus-541	37	24	was	be	AUX
finefocus-541	37	25	purchased	purchase	VERB
finefocus-541	37	26	from	from	ADP
finefocus-541	37	27	thermofisher	thermofisher	ADJ
finefocus-541	37	28	scientific	scientific	PROPN
finefocus-541	37	29	(	(	PUNCT
finefocus-541	37	30	waltham	waltham	PROPN
finefocus-541	37	31	,	,	PUNCT
finefocus-541	37	32	ma	ma	PROPN
finefocus-541	37	33	)	)	PUNCT
finefocus-541	37	34	.	.	PUNCT
finefocus-541	38	1	bacteria	bacteria	NOUN
finefocus-541	38	2	burkholderia	burkholderia	NOUN
finefocus-541	38	3	thailandensis	thailandensis	NOUN
finefocus-541	38	4	e264	e264	PROPN
finefocus-541	38	5	was	be	AUX
finefocus-541	38	6	purchased	purchase	VERB
finefocus-541	38	7	from	from	ADP
finefocus-541	38	8	american	american	ADJ
finefocus-541	38	9	type	type	NOUN
finefocus-541	38	10	culture	culture	NOUN
finefocus-541	38	11	collection	collection	NOUN
finefocus-541	38	12	(	(	PUNCT
finefocus-541	38	13	manassas	manassas	PROPN
finefocus-541	38	14	,	,	PUNCT
finefocus-541	38	15	va	va	NOUN
finefocus-541	38	16	)	)	PUNCT
finefocus-541	38	17	and	and	CCONJ
finefocus-541	38	18	used	use	VERB
finefocus-541	38	19	for	for	ADP
finefocus-541	38	20	all	all	DET
finefocus-541	38	21	experiments	experiment	NOUN
finefocus-541	38	22	.	.	PUNCT
finefocus-541	39	1	a	a	DET
finefocus-541	39	2	single	single	ADJ
finefocus-541	39	3	isolated	isolated	ADJ
finefocus-541	39	4	colony	colony	NOUN
finefocus-541	39	5	was	be	AUX
finefocus-541	39	6	inoculated	inoculate	VERB
finefocus-541	39	7	into	into	ADP
finefocus-541	39	8	sterile	sterile	ADJ
finefocus-541	39	9	lb	lb	DET
finefocus-541	39	10	broth	broth	NOUN
finefocus-541	39	11	and	and	CCONJ
finefocus-541	39	12	incubated	incubate	VERB
finefocus-541	39	13	on	on	ADP
finefocus-541	39	14	an	an	DET
finefocus-541	39	15	ambient	ambient	ADJ
finefocus-541	39	16	air	air	NOUN
finefocus-541	39	17	,	,	PUNCT
finefocus-541	39	18	shaking	shake	VERB
finefocus-541	39	19	incubator	incubator	NOUN
finefocus-541	39	20	at	at	ADP
finefocus-541	39	21	200	200	NUM
finefocus-541	39	22	rpm	rpm	NOUN
finefocus-541	39	23	for	for	ADP
finefocus-541	39	24	16	16	NUM
finefocus-541	39	25	hours	hour	NOUN
finefocus-541	39	26	at	at	ADP
finefocus-541	39	27	37	37	NUM
finefocus-541	39	28	°	°	NOUN
finefocus-541	39	29	c	c	NOUN
finefocus-541	39	30	.	.	PUNCT
finefocus-541	40	1	overnight	overnight	ADJ
finefocus-541	40	2	cultures	culture	NOUN
finefocus-541	40	3	were	be	AUX
finefocus-541	40	4	aliquoted	aliquote	VERB
finefocus-541	40	5	and	and	CCONJ
finefocus-541	40	6	stored	store	VERB
finefocus-541	40	7	at	at	ADP
finefocus-541	40	8	-80	-80	NOUN
finefocus-541	40	9	°	°	NOUN
finefocus-541	40	10	c	c	NOUN
finefocus-541	40	11	in	in	ADP
finefocus-541	40	12	0.5	0.5	NUM
finefocus-541	40	13	ml	ml	NOUN
finefocus-541	40	14	volumes	volume	NOUN
finefocus-541	40	15	as	as	ADP
finefocus-541	40	16	a	a	DET
finefocus-541	40	17	15	15	NUM
finefocus-541	40	18	%	%	NOUN
finefocus-541	40	19	glycerol	glycerol	NOUN
finefocus-541	40	20	stock	stock	NOUN
finefocus-541	40	21	solution	solution	NOUN
finefocus-541	40	22	.	.	PUNCT
finefocus-541	41	1	a	a	DET
finefocus-541	41	2	new	new	ADJ
finefocus-541	41	3	vial	vial	NOUN
finefocus-541	41	4	of	of	ADP
finefocus-541	41	5	b.	b.	PROPN
finefocus-541	41	6	thailandensis	thailandensis	NOUN
finefocus-541	41	7	was	be	AUX
finefocus-541	41	8	thawed	thaw	VERB
finefocus-541	41	9	and	and	CCONJ
finefocus-541	41	10	resuspended	resuspend	VERB
finefocus-541	41	11	immediately	immediately	ADV
finefocus-541	41	12	prior	prior	ADV
finefocus-541	41	13	to	to	ADP
finefocus-541	41	14	use	use	NOUN
finefocus-541	41	15	in	in	ADP
finefocus-541	41	16	the	the	DET
finefocus-541	41	17	macrophage	macrophage	ADJ
finefocus-541	41	18	infection	infection	NOUN
finefocus-541	41	19	assay	assay	VERB
finefocus-541	41	20	.	.	PUNCT
finefocus-541	42	1	cell	cell	NOUN
finefocus-541	42	2	lines	line	NOUN
finefocus-541	42	3	the	the	DET
finefocus-541	42	4	murine	murine	ADJ
finefocus-541	42	5	macrophage	macrophage	ADJ
finefocus-541	42	6	cell	cell	NOUN
finefocus-541	42	7	line	line	NOUN
finefocus-541	42	8	,	,	PUNCT
finefocus-541	42	9	raw	raw	ADJ
finefocus-541	42	10	264.7	264.7	NUM
finefocus-541	42	11	,	,	PUNCT
finefocus-541	42	12	was	be	AUX
finefocus-541	42	13	purchased	purchase	VERB
finefocus-541	42	14	from	from	ADP
finefocus-541	42	15	american	american	ADJ
finefocus-541	42	16	type	type	NOUN
finefocus-541	42	17	culture	culture	NOUN
finefocus-541	42	18	collection	collection	NOUN
finefocus-541	42	19	(	(	PUNCT
finefocus-541	42	20	manassas	manassas	PROPN
finefocus-541	42	21	,	,	PUNCT
finefocus-541	42	22	va	va	NOUN
finefocus-541	42	23	)	)	PUNCT
finefocus-541	42	24	and	and	CCONJ
finefocus-541	42	25	used	use	VERB
finefocus-541	42	26	for	for	ADP
finefocus-541	42	27	all	all	DET
finefocus-541	42	28	macrophage	macrophage	ADJ
finefocus-541	42	29	infections	infection	NOUN
finefocus-541	42	30	.	.	PUNCT
finefocus-541	43	1	macrophages	macrophage	NOUN
finefocus-541	43	2	were	be	AUX
finefocus-541	43	3	maintained	maintain	VERB
finefocus-541	43	4	in	in	ADP
finefocus-541	43	5	complete	complete	ADJ
finefocus-541	43	6	medium	medium	ADJ
finefocus-541	43	7	consisting	consisting	NOUN
finefocus-541	43	8	of	of	ADP
finefocus-541	43	9	1x	1x	NUM
finefocus-541	43	10	minimum	minimum	PROPN
finefocus-541	43	11	essential	essential	ADJ
finefocus-541	43	12	medium	medium	NOUN
finefocus-541	43	13	(	(	PUNCT
finefocus-541	43	14	mem	mem	ADJ
finefocus-541	43	15	;	;	PUNCT
finefocus-541	43	16	thermofisher	thermofisher	ADJ
finefocus-541	43	17	scientific	scientific	NOUN
finefocus-541	43	18	)	)	PUNCT
finefocus-541	43	19	supplemented	supplement	VERB
finefocus-541	43	20	to	to	ADP
finefocus-541	43	21	a	a	DET
finefocus-541	43	22	final	final	ADJ
finefocus-541	43	23	concentration	concentration	NOUN
finefocus-541	43	24	of	of	ADP
finefocus-541	43	25	10	10	NUM
finefocus-541	43	26	%	%	NOUN
finefocus-541	43	27	equafetal	equafetal	ADJ
finefocus-541	43	28	bovine	bovine	NOUN
finefocus-541	43	29	serum	serum	NOUN
finefocus-541	43	30	(	(	PUNCT
finefocus-541	43	31	atlas	atlas	PROPN
finefocus-541	43	32	biologicals	biological	NOUN
finefocus-541	43	33	,	,	PUNCT
finefocus-541	43	34	fort	fort	NOUN
finefocus-541	43	35	collins	collins	PROPN
finefocus-541	43	36	,	,	PUNCT
finefocus-541	43	37	co	co	NOUN
finefocus-541	43	38	)	)	PUNCT
finefocus-541	43	39	,	,	PUNCT
finefocus-541	43	40	1x	1x	NUM
finefocus-541	43	41	mem	mem	ADJ
finefocus-541	43	42	non	non	ADJ
finefocus-541	43	43	-	-	ADJ
finefocus-541	43	44	essential	essential	ADJ
finefocus-541	43	45	amino	amino	NOUN
finefocus-541	43	46	acids	acid	NOUN
finefocus-541	43	47	,	,	PUNCT
finefocus-541	43	48	0.5x	0.5x	NUM
finefocus-541	43	49	mem	mem	ADJ
finefocus-541	43	50	essential	essential	ADJ
finefocus-541	43	51	amino	amino	NOUN
finefocus-541	43	52	acids	acid	NOUN
finefocus-541	43	53	,	,	PUNCT
finefocus-541	43	54	0.075	0.075	NUM
finefocus-541	43	55	%	%	NOUN
finefocus-541	43	56	sodium	sodium	NOUN
finefocus-541	43	57	bicarbonate	bicarbonate	NOUN
finefocus-541	43	58	(	(	PUNCT
finefocus-541	43	59	sigma	sigma	NOUN
finefocus-541	43	60	-	-	PUNCT
finefocus-541	43	61	aldrich	aldrich	NOUN
finefocus-541	43	62	)	)	PUNCT
finefocus-541	43	63	,	,	PUNCT
finefocus-541	43	64	and	and	CCONJ
finefocus-541	43	65	2	2	NUM
finefocus-541	43	66	mm	mm	NOUN
finefocus-541	43	67	l	l	ADJ
finefocus-541	43	68	-	-	ADJ
finefocus-541	43	69	glutamine	glutamine	ADJ
finefocus-541	43	70	solution	solution	NOUN
finefocus-541	43	71	.	.	PUNCT
finefocus-541	44	1	in	in	ADP
finefocus-541	44	2	order	order	NOUN
finefocus-541	44	3	to	to	PART
finefocus-541	44	4	maintain	maintain	VERB
finefocus-541	44	5	sterility	sterility	NOUN
finefocus-541	44	6	of	of	ADP
finefocus-541	44	7	the	the	DET
finefocus-541	44	8	cells	cell	NOUN
finefocus-541	44	9	,	,	PUNCT
finefocus-541	44	10	passages	passage	NOUN
finefocus-541	44	11	of	of	ADP
finefocus-541	44	12	the	the	DET
finefocus-541	44	13	macrophages	macrophage	NOUN
finefocus-541	44	14	were	be	AUX
finefocus-541	44	15	maintained	maintain	VERB
finefocus-541	44	16	in	in	ADP
finefocus-541	44	17	complete	complete	ADJ
finefocus-541	44	18	mem	mem	NOUN
finefocus-541	44	19	supplemented	supplement	VERB
finefocus-541	44	20	to	to	ADP
finefocus-541	44	21	a	a	DET
finefocus-541	44	22	final	final	ADJ
finefocus-541	44	23	dilution	dilution	NOUN
finefocus-541	44	24	of	of	ADP
finefocus-541	44	25	100	100	NUM
finefocus-541	44	26	µg	µg	NOUN
finefocus-541	44	27	/	/	SYM
finefocus-541	44	28	ml	ml	NOUN
finefocus-541	44	29	of	of	ADP
finefocus-541	44	30	penicillin	penicillin	NOUN
finefocus-541	44	31	-	-	PUNCT
finefocus-541	44	32	streptomycin	streptomycin	PROPN
finefocus-541	44	33	solution	solution	NOUN
finefocus-541	44	34	.	.	PUNCT
finefocus-541	45	1	all	all	DET
finefocus-541	45	2	macrophage	macrophage	ADJ
finefocus-541	45	3	infections	infection	NOUN
finefocus-541	45	4	were	be	AUX
finefocus-541	45	5	performed	perform	VERB
finefocus-541	45	6	in	in	ADP
finefocus-541	45	7	antibiotic	antibiotic	ADJ
finefocus-541	45	8	-	-	PUNCT
finefocus-541	45	9	free	free	ADJ
finefocus-541	45	10	complete	complete	ADJ
finefocus-541	45	11	mem	mem	NOUN
finefocus-541	45	12	(	(	PUNCT
finefocus-541	45	13	cmem	cmem	PROPN
finefocus-541	45	14	)	)	PUNCT
finefocus-541	45	15	.	.	PUNCT
finefocus-541	46	1	macrophages	macrophage	NOUN
finefocus-541	46	2	were	be	AUX
finefocus-541	46	3	maintained	maintain	VERB
finefocus-541	46	4	in	in	ADP
finefocus-541	46	5	a	a	DET
finefocus-541	46	6	37	37	NUM
finefocus-541	46	7	°	°	NOUN
finefocus-541	46	8	c	c	NOUN
finefocus-541	46	9	incubator	incubator	NOUN
finefocus-541	46	10	supplemented	supplement	VERB
finefocus-541	46	11	with	with	ADP
finefocus-541	46	12	5	5	NUM
finefocus-541	46	13	%	%	NOUN
finefocus-541	46	14	co2	co2	NOUN
finefocus-541	46	15	and	and	CCONJ
finefocus-541	46	16	80	80	NUM
finefocus-541	46	17	%	%	NOUN
finefocus-541	46	18	relative	relative	ADJ
finefocus-541	46	19	humidity	humidity	NOUN
finefocus-541	46	20	.	.	PUNCT
finefocus-541	47	1	macrophage	macrophage	ADJ
finefocus-541	47	2	infection	infection	NOUN
finefocus-541	47	3	assay	assay	VERB
finefocus-541	47	4	the	the	DET
finefocus-541	47	5	macrophage	macrophage	ADJ
finefocus-541	47	6	infection	infection	NOUN
finefocus-541	47	7	was	be	AUX
finefocus-541	47	8	conducted	conduct	VERB
finefocus-541	47	9	as	as	ADP
finefocus-541	47	10	previously	previously	ADV
finefocus-541	47	11	described	describe	VERB
finefocus-541	47	12	(	(	PUNCT
finefocus-541	47	13	10	10	NUM
finefocus-541	47	14	,	,	PUNCT
finefocus-541	47	15	12	12	NUM
finefocus-541	47	16	)	)	PUNCT
finefocus-541	47	17	.	.	PUNCT
finefocus-541	48	1	briefly	briefly	NOUN
finefocus-541	48	2	,	,	PUNCT
finefocus-541	48	3	a	a	DET
finefocus-541	48	4	hemocytometer	hemocytometer	NOUN
finefocus-541	48	5	was	be	AUX
finefocus-541	48	6	used	use	VERB
finefocus-541	48	7	to	to	PART
finefocus-541	48	8	appropriately	appropriately	ADV
finefocus-541	48	9	count	count	VERB
finefocus-541	48	10	and	and	CCONJ
finefocus-541	48	11	dilute	dilute	VERB
finefocus-541	48	12	the	the	DET
finefocus-541	48	13	raw	raw	ADJ
finefocus-541	48	14	cells	cell	NOUN
finefocus-541	48	15	to	to	ADP
finefocus-541	48	16	a	a	DET
finefocus-541	48	17	density	density	NOUN
finefocus-541	48	18	of	of	ADP
finefocus-541	48	19	200,000	200,000	NUM
finefocus-541	48	20	cells	cell	NOUN
finefocus-541	48	21	per	per	ADP
finefocus-541	48	22	well	well	ADV
finefocus-541	48	23	in	in	ADP
finefocus-541	48	24	0.5	0.5	NUM
finefocus-541	48	25	ml	ml	NOUN
finefocus-541	48	26	of	of	ADP
finefocus-541	48	27	cmem	cmem	NOUN
finefocus-541	48	28	.	.	PUNCT
finefocus-541	49	1	after	after	SCONJ
finefocus-541	49	2	the	the	DET
finefocus-541	49	3	cells	cell	NOUN
finefocus-541	49	4	were	be	AUX
finefocus-541	49	5	added	add	VERB
finefocus-541	49	6	to	to	ADP
finefocus-541	49	7	a	a	DET
finefocus-541	49	8	24	24	NUM
finefocus-541	49	9	-	-	PUNCT
finefocus-541	49	10	well	well	NOUN
finefocus-541	49	11	plate	plate	NOUN
finefocus-541	49	12	,	,	PUNCT
finefocus-541	49	13	they	they	PRON
finefocus-541	49	14	were	be	AUX
finefocus-541	49	15	incubated	incubate	VERB
finefocus-541	49	16	at	at	ADP
finefocus-541	49	17	37	37	NUM
finefocus-541	49	18	°	°	ADP
finefocus-541	49	19	c	c	NOUN
finefocus-541	49	20	with	with	ADP
finefocus-541	49	21	5	5	NUM
finefocus-541	49	22	%	%	NOUN
finefocus-541	49	23	co2	co2	NOUN
finefocus-541	49	24	and	and	CCONJ
finefocus-541	49	25	80	80	NUM
finefocus-541	49	26	%	%	NOUN
finefocus-541	49	27	humidity	humidity	NOUN
finefocus-541	49	28	overnight	overnight	ADP
finefocus-541	49	29	121pathogens	121pathogens	PROPN
finefocus-541	49	30	&	&	CCONJ
finefocus-541	49	31	antimicrobial	antimicrobial	ADJ
finefocus-541	49	32	factors	factor	NOUN
finefocus-541	49	33	•	•	ADV
finefocus-541	49	34	for	for	ADP
finefocus-541	49	35	adherence	adherence	NOUN
finefocus-541	49	36	.	.	PUNCT
finefocus-541	50	1	after	after	ADP
finefocus-541	50	2	this	this	DET
finefocus-541	50	3	incubation	incubation	NOUN
finefocus-541	50	4	period	period	NOUN
finefocus-541	50	5	,	,	PUNCT
finefocus-541	50	6	the	the	DET
finefocus-541	50	7	cells	cell	NOUN
finefocus-541	50	8	were	be	AUX
finefocus-541	50	9	observed	observe	VERB
finefocus-541	50	10	under	under	ADP
finefocus-541	50	11	an	an	DET
finefocus-541	50	12	inverted	inverted	ADJ
finefocus-541	50	13	microscope	microscope	NOUN
finefocus-541	50	14	to	to	PART
finefocus-541	50	15	determine	determine	VERB
finefocus-541	50	16	the	the	DET
finefocus-541	50	17	general	general	ADJ
finefocus-541	50	18	health	health	NOUN
finefocus-541	50	19	of	of	ADP
finefocus-541	50	20	the	the	DET
finefocus-541	50	21	cells	cell	NOUN
finefocus-541	50	22	.	.	PUNCT
finefocus-541	51	1	the	the	DET
finefocus-541	51	2	cells	cell	NOUN
finefocus-541	51	3	in	in	ADP
finefocus-541	51	4	each	each	DET
finefocus-541	51	5	well	well	ADV
finefocus-541	51	6	were	be	AUX
finefocus-541	51	7	washed	wash	VERB
finefocus-541	51	8	one	one	NUM
finefocus-541	51	9	time	time	NOUN
finefocus-541	51	10	,	,	PUNCT
finefocus-541	51	11	slowly	slowly	ADV
finefocus-541	51	12	and	and	CCONJ
finefocus-541	51	13	carefully	carefully	ADV
finefocus-541	51	14	,	,	PUNCT
finefocus-541	51	15	with	with	ADP
finefocus-541	51	16	1	1	NUM
finefocus-541	51	17	ml	ml	NOUN
finefocus-541	51	18	of	of	ADP
finefocus-541	51	19	phosphate	phosphate	ADJ
finefocus-541	51	20	buffered	buffer	VERB
finefocus-541	51	21	saline	saline	NOUN
finefocus-541	51	22	(	(	PUNCT
finefocus-541	51	23	pbs	pbs	PROPN
finefocus-541	51	24	)	)	PUNCT
finefocus-541	51	25	.	.	PUNCT
finefocus-541	52	1	a	a	DET
finefocus-541	52	2	bacteria	bacteria	NOUN
finefocus-541	52	3	dilution	dilution	NOUN
finefocus-541	52	4	of	of	ADP
finefocus-541	52	5	b.	b.	PROPN
finefocus-541	52	6	thailandensis	thailandensis	PROPN
finefocus-541	52	7	in	in	ADP
finefocus-541	52	8	cmem	cmem	NOUN
finefocus-541	52	9	was	be	AUX
finefocus-541	52	10	then	then	ADV
finefocus-541	52	11	applied	apply	VERB
finefocus-541	52	12	to	to	ADP
finefocus-541	52	13	the	the	DET
finefocus-541	52	14	cells	cell	NOUN
finefocus-541	52	15	at	at	ADP
finefocus-541	52	16	a	a	DET
finefocus-541	52	17	multiplicity	multiplicity	NOUN
finefocus-541	52	18	of	of	ADP
finefocus-541	52	19	infection	infection	NOUN
finefocus-541	52	20	of	of	ADP
finefocus-541	52	21	5	5	NUM
finefocus-541	52	22	,	,	PUNCT
finefocus-541	52	23	and	and	CCONJ
finefocus-541	52	24	incubated	incubate	VERB
finefocus-541	52	25	for	for	ADP
finefocus-541	52	26	1	1	NUM
finefocus-541	52	27	hour	hour	NOUN
finefocus-541	52	28	.	.	PUNCT
finefocus-541	53	1	after	after	ADP
finefocus-541	53	2	the	the	DET
finefocus-541	53	3	first	first	ADJ
finefocus-541	53	4	hour	hour	NOUN
finefocus-541	53	5	of	of	ADP
finefocus-541	53	6	incubation	incubation	NOUN
finefocus-541	53	7	,	,	PUNCT
finefocus-541	53	8	the	the	DET
finefocus-541	53	9	cells	cell	NOUN
finefocus-541	53	10	were	be	AUX
finefocus-541	53	11	again	again	ADV
finefocus-541	53	12	slowly	slowly	ADV
finefocus-541	53	13	washed	wash	VERB
finefocus-541	53	14	one	one	NUM
finefocus-541	53	15	time	time	NOUN
finefocus-541	53	16	with	with	ADP
finefocus-541	53	17	2	2	NUM
finefocus-541	53	18	ml	ml	NOUN
finefocus-541	53	19	of	of	ADP
finefocus-541	53	20	pbs	pbs	PROPN
finefocus-541	53	21	and	and	CCONJ
finefocus-541	53	22	then	then	ADV
finefocus-541	53	23	1	1	NUM
finefocus-541	53	24	ml	ml	NOUN
finefocus-541	53	25	of	of	ADP
finefocus-541	53	26	a	a	DET
finefocus-541	53	27	350	350	NUM
finefocus-541	53	28	µg	µg	NOUN
finefocus-541	53	29	/	/	SYM
finefocus-541	53	30	ml	ml	ADP
finefocus-541	53	31	kanamycin	kanamycin	NOUN
finefocus-541	53	32	solution	solution	NOUN
finefocus-541	53	33	was	be	AUX
finefocus-541	53	34	added	add	VERB
finefocus-541	53	35	into	into	ADP
finefocus-541	53	36	each	each	PRON
finefocus-541	53	37	of	of	ADP
finefocus-541	53	38	the	the	DET
finefocus-541	53	39	wells	well	NOUN
finefocus-541	53	40	and	and	CCONJ
finefocus-541	53	41	incubated	incubate	VERB
finefocus-541	53	42	for	for	ADP
finefocus-541	53	43	1	1	NUM
finefocus-541	53	44	hour	hour	NOUN
finefocus-541	53	45	to	to	PART
finefocus-541	53	46	remove	remove	VERB
finefocus-541	53	47	extracellular	extracellular	ADJ
finefocus-541	53	48	bacteria	bacteria	NOUN
finefocus-541	53	49	.	.	PUNCT
finefocus-541	54	1	after	after	ADP
finefocus-541	54	2	this	this	DET
finefocus-541	54	3	final	final	ADJ
finefocus-541	54	4	incubation	incubation	NOUN
finefocus-541	54	5	period	period	NOUN
finefocus-541	54	6	,	,	PUNCT
finefocus-541	54	7	the	the	DET
finefocus-541	54	8	cells	cell	NOUN
finefocus-541	54	9	were	be	AUX
finefocus-541	54	10	washed	wash	VERB
finefocus-541	54	11	two	two	NUM
finefocus-541	54	12	times	time	NOUN
finefocus-541	54	13	with	with	ADP
finefocus-541	54	14	2	2	NUM
finefocus-541	54	15	ml	ml	NOUN
finefocus-541	54	16	of	of	ADP
finefocus-541	54	17	pbs	pbs	PROPN
finefocus-541	54	18	to	to	PART
finefocus-541	54	19	remove	remove	VERB
finefocus-541	54	20	the	the	DET
finefocus-541	54	21	killed	kill	VERB
finefocus-541	54	22	extracellular	extracellular	ADJ
finefocus-541	54	23	bacteria	bacteria	NOUN
finefocus-541	54	24	.	.	PUNCT
finefocus-541	55	1	then	then	ADV
finefocus-541	55	2	0.5	0.5	NUM
finefocus-541	55	3	ml	ml	NOUN
finefocus-541	55	4	of	of	ADP
finefocus-541	55	5	a	a	DET
finefocus-541	55	6	10	10	NUM
finefocus-541	55	7	µg	µg	NOUN
finefocus-541	55	8	/	/	SYM
finefocus-541	55	9	ml	ml	NOUN
finefocus-541	55	10	solution	solution	NOUN
finefocus-541	55	11	of	of	ADP
finefocus-541	55	12	ceftazidime	ceftazidime	NOUN
finefocus-541	55	13	,	,	PUNCT
finefocus-541	55	14	was	be	AUX
finefocus-541	55	15	added	add	VERB
finefocus-541	55	16	into	into	ADP
finefocus-541	55	17	each	each	PRON
finefocus-541	55	18	of	of	ADP
finefocus-541	55	19	the	the	DET
finefocus-541	55	20	wells	well	NOUN
finefocus-541	55	21	and	and	CCONJ
finefocus-541	55	22	incubated	incubate	VERB
finefocus-541	55	23	for	for	ADP
finefocus-541	55	24	18	18	NUM
finefocus-541	55	25	-	-	SYM
finefocus-541	55	26	24	24	NUM
finefocus-541	55	27	hours	hour	NOUN
finefocus-541	55	28	.	.	PUNCT
finefocus-541	56	1	testing	test	VERB
finefocus-541	56	2	for	for	ADP
finefocus-541	56	3	antibiotic	antibiotic	ADJ
finefocus-541	56	4	resistance	resistance	NOUN
finefocus-541	56	5	after	after	ADP
finefocus-541	56	6	24	24	NUM
finefocus-541	56	7	hours	hour	NOUN
finefocus-541	56	8	of	of	ADP
finefocus-541	56	9	infection	infection	NOUN
finefocus-541	56	10	and	and	CCONJ
finefocus-541	56	11	treatments	treatment	NOUN
finefocus-541	56	12	,	,	PUNCT
finefocus-541	56	13	the	the	DET
finefocus-541	56	14	remaining	remain	VERB
finefocus-541	56	15	extracellular	extracellular	ADJ
finefocus-541	56	16	bacteria	bacteria	NOUN
finefocus-541	56	17	were	be	AUX
finefocus-541	56	18	carefully	carefully	ADV
finefocus-541	56	19	resuspended	resuspend	VERB
finefocus-541	56	20	in	in	ADP
finefocus-541	56	21	their	their	PRON
finefocus-541	56	22	wells	well	NOUN
finefocus-541	56	23	and	and	CCONJ
finefocus-541	56	24	100µl	100µl	PROPN
finefocus-541	56	25	was	be	AUX
finefocus-541	56	26	directly	directly	ADV
finefocus-541	56	27	plated	plate	VERB
finefocus-541	56	28	onto	onto	ADP
finefocus-541	56	29	agar	agar	NOUN
finefocus-541	56	30	with	with	ADP
finefocus-541	56	31	varying	vary	VERB
finefocus-541	56	32	concentrations	concentration	NOUN
finefocus-541	56	33	of	of	ADP
finefocus-541	56	34	ceftazidime	ceftazidime	NOUN
finefocus-541	56	35	.	.	PUNCT
finefocus-541	57	1	the	the	DET
finefocus-541	57	2	agar	agar	NOUN
finefocus-541	57	3	plates	plate	NOUN
finefocus-541	57	4	contained	contain	VERB
finefocus-541	57	5	either	either	CCONJ
finefocus-541	57	6	no	no	DET
finefocus-541	57	7	antibiotic	antibiotic	ADJ
finefocus-541	57	8	,	,	PUNCT
finefocus-541	57	9	10	10	NUM
finefocus-541	57	10	µg	µg	NOUN
finefocus-541	57	11	/	/	SYM
finefocus-541	57	12	ml	ml	NOUN
finefocus-541	57	13	of	of	ADP
finefocus-541	57	14	ceftazidime	ceftazidime	NOUN
finefocus-541	57	15	,	,	PUNCT
finefocus-541	57	16	or	or	CCONJ
finefocus-541	57	17	200	200	NUM
finefocus-541	57	18	µg	µg	NOUN
finefocus-541	57	19	/	/	SYM
finefocus-541	57	20	ml	ml	NOUN
finefocus-541	57	21	of	of	ADP
finefocus-541	57	22	ceftazidime	ceftazidime	NOUN
finefocus-541	57	23	(	(	PUNCT
finefocus-541	57	24	which	which	PRON
finefocus-541	57	25	equates	equate	VERB
finefocus-541	57	26	to	to	ADP
finefocus-541	57	27	~100x	~100x	NUM
finefocus-541	57	28	minimal	minimal	ADJ
finefocus-541	57	29	inhibitory	inhibitory	ADJ
finefocus-541	57	30	concentration	concentration	NOUN
finefocus-541	57	31	(	(	PUNCT
finefocus-541	57	32	mic	mic	NOUN
finefocus-541	57	33	)	)	PUNCT
finefocus-541	57	34	of	of	ADP
finefocus-541	57	35	1.75	1.75	NUM
finefocus-541	57	36	µg	µg	NOUN
finefocus-541	57	37	/	/	SYM
finefocus-541	57	38	ml	ml	NOUN
finefocus-541	57	39	)	)	PUNCT
finefocus-541	57	40	(	(	PUNCT
finefocus-541	57	41	20	20	NUM
finefocus-541	57	42	)	)	PUNCT
finefocus-541	57	43	.	.	PUNCT
finefocus-541	58	1	plates	plate	NOUN
finefocus-541	58	2	were	be	AUX
finefocus-541	58	3	incubated	incubate	VERB
finefocus-541	58	4	in	in	ADP
finefocus-541	58	5	an	an	DET
finefocus-541	58	6	ambient	ambient	ADJ
finefocus-541	58	7	air	air	NOUN
finefocus-541	58	8	incubator	incubator	NOUN
finefocus-541	58	9	for	for	ADP
finefocus-541	58	10	24	24	NUM
finefocus-541	58	11	-	-	SYM
finefocus-541	58	12	36	36	NUM
finefocus-541	58	13	hours	hour	NOUN
finefocus-541	58	14	at	at	ADP
finefocus-541	58	15	37	37	NUM
finefocus-541	58	16	°	°	ADP
finefocus-541	58	17	c	c	NOUN
finefocus-541	58	18	and	and	CCONJ
finefocus-541	58	19	then	then	ADV
finefocus-541	58	20	inspected	inspect	VERB
finefocus-541	58	21	for	for	ADP
finefocus-541	58	22	growth	growth	NOUN
finefocus-541	58	23	.	.	PUNCT
finefocus-541	59	1	testing	test	VERB
finefocus-541	59	2	for	for	ADP
finefocus-541	59	3	persister	persister	ADJ
finefocus-541	59	4	cell	cell	NOUN
finefocus-541	59	5	formation	formation	NOUN
finefocus-541	59	6	after	after	ADP
finefocus-541	59	7	the	the	DET
finefocus-541	59	8	18	18	NUM
finefocus-541	59	9	-	-	PUNCT
finefocus-541	59	10	hour	hour	NOUN
finefocus-541	59	11	treatment	treatment	NOUN
finefocus-541	59	12	period	period	NOUN
finefocus-541	59	13	of	of	ADP
finefocus-541	59	14	the	the	DET
finefocus-541	59	15	macrophage	macrophage	ADJ
finefocus-541	59	16	infection	infection	NOUN
finefocus-541	59	17	assay	assay	VERB
finefocus-541	59	18	,	,	PUNCT
finefocus-541	59	19	macrophages	macrophage	NOUN
finefocus-541	59	20	were	be	AUX
finefocus-541	59	21	inspected	inspect	VERB
finefocus-541	59	22	for	for	ADP
finefocus-541	59	23	apparent	apparent	ADJ
finefocus-541	59	24	signs	sign	NOUN
finefocus-541	59	25	of	of	ADP
finefocus-541	59	26	infection	infection	NOUN
finefocus-541	59	27	and	and	CCONJ
finefocus-541	59	28	consistency	consistency	NOUN
finefocus-541	59	29	between	between	ADP
finefocus-541	59	30	wells	well	NOUN
finefocus-541	59	31	.	.	PUNCT
finefocus-541	60	1	remaining	remain	VERB
finefocus-541	60	2	extracellular	extracellular	ADJ
finefocus-541	60	3	bacteria	bacteria	NOUN
finefocus-541	60	4	were	be	AUX
finefocus-541	60	5	resuspended	resuspend	VERB
finefocus-541	60	6	slowly	slowly	ADV
finefocus-541	60	7	and	and	CCONJ
finefocus-541	60	8	carefully	carefully	ADV
finefocus-541	60	9	,	,	PUNCT
finefocus-541	60	10	and	and	CCONJ
finefocus-541	60	11	transferred	transfer	VERB
finefocus-541	60	12	to	to	ADP
finefocus-541	60	13	2	2	NUM
finefocus-541	60	14	ml	ml	ADP
finefocus-541	60	15	tubes	tube	NOUN
finefocus-541	60	16	,	,	PUNCT
finefocus-541	60	17	combining	combine	VERB
finefocus-541	60	18	two	two	NUM
finefocus-541	60	19	identical	identical	ADJ
finefocus-541	60	20	wells	well	NOUN
finefocus-541	60	21	into	into	ADP
finefocus-541	60	22	1	1	NUM
finefocus-541	60	23	tube	tube	NOUN
finefocus-541	60	24	due	due	ADP
finefocus-541	60	25	to	to	ADP
finefocus-541	60	26	low	low	ADJ
finefocus-541	60	27	numbers	number	NOUN
finefocus-541	60	28	of	of	ADP
finefocus-541	60	29	remaining	remain	VERB
finefocus-541	60	30	bacteria	bacteria	NOUN
finefocus-541	60	31	.	.	PUNCT
finefocus-541	61	1	tubes	tube	NOUN
finefocus-541	61	2	of	of	ADP
finefocus-541	61	3	bacteria	bacteria	NOUN
finefocus-541	61	4	were	be	AUX
finefocus-541	61	5	centrifuged	centrifuge	VERB
finefocus-541	61	6	at	at	ADP
finefocus-541	61	7	12000	12000	NUM
finefocus-541	61	8	xg	xg	NOUN
finefocus-541	61	9	for	for	ADP
finefocus-541	61	10	five	five	NUM
finefocus-541	61	11	minutes	minute	NOUN
finefocus-541	61	12	,	,	PUNCT
finefocus-541	61	13	the	the	DET
finefocus-541	61	14	supernatant	supernatant	NOUN
finefocus-541	61	15	was	be	AUX
finefocus-541	61	16	carefully	carefully	ADV
finefocus-541	61	17	removed	remove	VERB
finefocus-541	61	18	,	,	PUNCT
finefocus-541	61	19	and	and	CCONJ
finefocus-541	61	20	a	a	DET
finefocus-541	61	21	1	1	NUM
finefocus-541	61	22	ml	ml	NOUN
finefocus-541	61	23	wash	wash	VERB
finefocus-541	61	24	with	with	ADP
finefocus-541	61	25	complete	complete	ADJ
finefocus-541	61	26	cmem	cmem	NOUN
finefocus-541	61	27	was	be	AUX
finefocus-541	61	28	added	add	VERB
finefocus-541	61	29	to	to	ADP
finefocus-541	61	30	each	each	DET
finefocus-541	61	31	tube	tube	NOUN
finefocus-541	61	32	.	.	PUNCT
finefocus-541	62	1	after	after	ADP
finefocus-541	62	2	a	a	DET
finefocus-541	62	3	second	second	ADJ
finefocus-541	62	4	spin	spin	NOUN
finefocus-541	62	5	,	,	PUNCT
finefocus-541	62	6	the	the	DET
finefocus-541	62	7	pellets	pellet	NOUN
finefocus-541	62	8	were	be	AUX
finefocus-541	62	9	reconstituted	reconstitute	VERB
finefocus-541	62	10	in	in	ADP
finefocus-541	62	11	0.5	0.5	NUM
finefocus-541	62	12	ml	ml	NOUN
finefocus-541	62	13	cmem	cmem	NOUN
finefocus-541	62	14	and	and	CCONJ
finefocus-541	62	15	the	the	DET
finefocus-541	62	16	entire	entire	ADJ
finefocus-541	62	17	tube	tube	NOUN
finefocus-541	62	18	contents	content	NOUN
finefocus-541	62	19	were	be	AUX
finefocus-541	62	20	plated	plate	VERB
finefocus-541	62	21	into	into	ADP
finefocus-541	62	22	separate	separate	ADJ
finefocus-541	62	23	wells	well	NOUN
finefocus-541	62	24	of	of	ADP
finefocus-541	62	25	a	a	DET
finefocus-541	62	26	new	new	ADJ
finefocus-541	62	27	24	24	NUM
finefocus-541	62	28	-	-	PUNCT
finefocus-541	62	29	well	well	NOUN
finefocus-541	62	30	plate	plate	NOUN
finefocus-541	62	31	.	.	PUNCT
finefocus-541	63	1	ceftazidime	ceftazidime	NOUN
finefocus-541	63	2	was	be	AUX
finefocus-541	63	3	readded	readde	VERB
finefocus-541	63	4	to	to	ADP
finefocus-541	63	5	a	a	DET
finefocus-541	63	6	final	final	ADJ
finefocus-541	63	7	concentration	concentration	NOUN
finefocus-541	63	8	of	of	ADP
finefocus-541	63	9	200	200	NUM
finefocus-541	63	10	µg/	µg/	NOUN
finefocus-541	63	11	ml	ml	NOUN
finefocus-541	63	12	and	and	CCONJ
finefocus-541	63	13	returned	return	VERB
finefocus-541	63	14	to	to	ADP
finefocus-541	63	15	the	the	DET
finefocus-541	63	16	incubator	incubator	NOUN
finefocus-541	63	17	at	at	ADP
finefocus-541	63	18	37	37	NUM
finefocus-541	63	19	°	°	ADP
finefocus-541	63	20	c	c	NOUN
finefocus-541	63	21	with	with	ADP
finefocus-541	63	22	5	5	NUM
finefocus-541	63	23	%	%	NOUN
finefocus-541	63	24	co2	co2	NOUN
finefocus-541	63	25	and	and	CCONJ
finefocus-541	63	26	80	80	NUM
finefocus-541	63	27	%	%	NOUN
finefocus-541	63	28	humidity	humidity	NOUN
finefocus-541	63	29	.	.	PUNCT
finefocus-541	64	1	subjecting	subject	VERB
finefocus-541	64	2	bacteria	bacteria	NOUN
finefocus-541	64	3	to	to	ADP
finefocus-541	64	4	very	very	ADV
finefocus-541	64	5	high	high	ADJ
finefocus-541	64	6	doses	dose	NOUN
finefocus-541	64	7	of	of	ADP
finefocus-541	64	8	antibiotics	antibiotic	NOUN
finefocus-541	64	9	is	be	AUX
finefocus-541	64	10	one	one	NUM
finefocus-541	64	11	way	way	NOUN
finefocus-541	64	12	to	to	PART
finefocus-541	64	13	identify	identify	VERB
finefocus-541	64	14	persister	persister	ADJ
finefocus-541	64	15	cells	cell	NOUN
finefocus-541	64	16	(	(	PUNCT
finefocus-541	64	17	7	7	NUM
finefocus-541	64	18	)	)	PUNCT
finefocus-541	64	19	.	.	PUNCT
finefocus-541	65	1	serial	serial	ADJ
finefocus-541	65	2	dilutions	dilution	NOUN
finefocus-541	65	3	of	of	ADP
finefocus-541	65	4	the	the	DET
finefocus-541	65	5	surviving	survive	VERB
finefocus-541	65	6	bacteria	bacteria	NOUN
finefocus-541	65	7	were	be	AUX
finefocus-541	65	8	plated	plate	VERB
finefocus-541	65	9	at	at	ADP
finefocus-541	65	10	various	various	ADJ
finefocus-541	65	11	time	time	NOUN
finefocus-541	65	12	points	point	NOUN
finefocus-541	65	13	postantibiotic	postantibiotic	ADJ
finefocus-541	65	14	treatment	treatment	NOUN
finefocus-541	65	15	,	,	PUNCT
finefocus-541	65	16	and	and	CCONJ
finefocus-541	65	17	bacterial	bacterial	ADJ
finefocus-541	65	18	density	density	NOUN
finefocus-541	65	19	was	be	AUX
finefocus-541	65	20	calculated	calculate	VERB
finefocus-541	65	21	as	as	ADP
finefocus-541	65	22	colony	colony	NOUN
finefocus-541	65	23	forming	form	VERB
finefocus-541	65	24	units	unit	NOUN
finefocus-541	65	25	per	per	ADP
finefocus-541	65	26	milliliter	milliliter	NOUN
finefocus-541	65	27	(	(	PUNCT
finefocus-541	65	28	cfu	cfu	NOUN
finefocus-541	65	29	/	/	SYM
finefocus-541	65	30	ml	ml	NOUN
finefocus-541	65	31	)	)	PUNCT
finefocus-541	65	32	after	after	ADP
finefocus-541	65	33	incubation	incubation	NOUN
finefocus-541	65	34	of	of	ADP
finefocus-541	65	35	the	the	DET
finefocus-541	65	36	agar	agar	NOUN
finefocus-541	65	37	plates	plate	NOUN
finefocus-541	65	38	.	.	PUNCT
finefocus-541	66	1	statistical	statistical	ADJ
finefocus-541	66	2	analyses	analysis	NOUN
finefocus-541	66	3	prism	prism	NOUN
finefocus-541	66	4	software	software	NOUN
finefocus-541	66	5	version	version	NOUN
finefocus-541	66	6	7.01	7.01	NUM
finefocus-541	66	7	(	(	PUNCT
finefocus-541	66	8	graphpad	graphpad	NOUN
finefocus-541	66	9	,	,	PUNCT
finefocus-541	66	10	la	la	PROPN
finefocus-541	66	11	jolla	jolla	PROPN
finefocus-541	66	12	,	,	PUNCT
finefocus-541	66	13	ca	ca	NOUN
finefocus-541	66	14	)	)	PUNCT
finefocus-541	66	15	was	be	AUX
finefocus-541	66	16	used	use	VERB
finefocus-541	66	17	to	to	PART
finefocus-541	66	18	plot	plot	VERB
finefocus-541	66	19	the	the	DET
finefocus-541	66	20	mean	mean	ADJ
finefocus-541	66	21	and	and	CCONJ
finefocus-541	66	22	standard	standard	ADJ
finefocus-541	66	23	error	error	NOUN
finefocus-541	66	24	of	of	ADP
finefocus-541	66	25	the	the	DET
finefocus-541	66	26	mean	mean	ADJ
finefocus-541	66	27	(	(	PUNCT
finefocus-541	66	28	sem	sem	NOUN
finefocus-541	66	29	)	)	PUNCT
finefocus-541	66	30	for	for	ADP
finefocus-541	66	31	different	different	ADJ
finefocus-541	66	32	treatment	treatment	NOUN
finefocus-541	66	33	groups	group	NOUN
finefocus-541	66	34	.	.	PUNCT
finefocus-541	67	1	one	one	NUM
finefocus-541	67	2	-	-	PUNCT
finefocus-541	67	3	way	way	NOUN
finefocus-541	67	4	analysis	analysis	NOUN
finefocus-541	67	5	of	of	ADP
finefocus-541	67	6	variance	variance	NOUN
finefocus-541	67	7	(	(	PUNCT
finefocus-541	67	8	anova	anova	PROPN
finefocus-541	67	9	)	)	PUNCT
finefocus-541	67	10	and	and	CCONJ
finefocus-541	67	11	tukey	tukey	PROPN
finefocus-541	67	12	’s	’s	PART
finefocus-541	67	13	post	post	PROPN
finefocus-541	67	14	test	test	NOUN
finefocus-541	67	15	was	be	AUX
finefocus-541	67	16	used	use	VERB
finefocus-541	67	17	to	to	PART
finefocus-541	67	18	compare	compare	VERB
finefocus-541	67	19	differences	difference	NOUN
finefocus-541	67	20	between	between	ADP
finefocus-541	67	21	three	three	NUM
finefocus-541	67	22	or	or	CCONJ
finefocus-541	67	23	more	more	ADJ
finefocus-541	67	24	treatment	treatment	NOUN
finefocus-541	67	25	groups	group	NOUN
finefocus-541	67	26	.	.	PUNCT
finefocus-541	68	1	122•	122•	NUM
finefocus-541	68	2	fine	fine	ADJ
finefocus-541	68	3	focus	focus	NOUN
finefocus-541	68	4	,	,	PUNCT
finefocus-541	68	5	vol	vol	NOUN
finefocus-541	68	6	.	.	PUNCT
finefocus-541	68	7	4(1	4(1	NOUN
finefocus-541	68	8	)	)	PUNCT
finefocus-541	68	9	results	result	VERB
finefocus-541	68	10	testing	test	VERB
finefocus-541	68	11	for	for	ADP
finefocus-541	68	12	classical	classical	ADJ
finefocus-541	68	13	resistance	resistance	NOUN
finefocus-541	68	14	previously	previously	ADV
finefocus-541	68	15	,	,	PUNCT
finefocus-541	68	16	we	we	PRON
finefocus-541	68	17	found	find	VERB
finefocus-541	68	18	that	that	SCONJ
finefocus-541	68	19	treatment	treatment	NOUN
finefocus-541	68	20	of	of	ADP
finefocus-541	68	21	b.	b.	PROPN
finefocus-541	68	22	thailandensis	thailandensis	PROPN
finefocus-541	68	23	-	-	PUNCT
finefocus-541	68	24	infected	infect	VERB
finefocus-541	68	25	macrophages	macrophage	NOUN
finefocus-541	68	26	failed	fail	VERB
finefocus-541	68	27	to	to	PART
finefocus-541	68	28	kill	kill	VERB
finefocus-541	68	29	all	all	DET
finefocus-541	68	30	extracellular	extracellular	ADJ
finefocus-541	68	31	bacteria	bacteria	NOUN
finefocus-541	68	32	even	even	ADV
finefocus-541	68	33	after	after	ADP
finefocus-541	68	34	18	18	NUM
finefocus-541	68	35	-	-	SYM
finefocus-541	68	36	24	24	NUM
finefocus-541	68	37	hours	hour	NOUN
finefocus-541	68	38	of	of	ADP
finefocus-541	68	39	exposure	exposure	NOUN
finefocus-541	68	40	to	to	ADP
finefocus-541	68	41	ceftazidime	ceftazidime	NOUN
finefocus-541	68	42	above	above	ADP
finefocus-541	68	43	the	the	DET
finefocus-541	68	44	mic	mic	NOUN
finefocus-541	68	45	.	.	PUNCT
finefocus-541	69	1	to	to	PART
finefocus-541	69	2	determine	determine	VERB
finefocus-541	69	3	if	if	SCONJ
finefocus-541	69	4	these	these	DET
finefocus-541	69	5	remaining	remain	VERB
finefocus-541	69	6	bacteria	bacteria	NOUN
finefocus-541	69	7	had	have	AUX
finefocus-541	69	8	developed	develop	VERB
finefocus-541	69	9	classical	classical	ADJ
finefocus-541	69	10	resistance	resistance	NOUN
finefocus-541	69	11	to	to	ADP
finefocus-541	69	12	ceftazidime	ceftazidime	NOUN
finefocus-541	69	13	during	during	ADP
finefocus-541	69	14	the	the	DET
finefocus-541	69	15	treatment	treatment	NOUN
finefocus-541	69	16	,	,	PUNCT
finefocus-541	69	17	we	we	PRON
finefocus-541	69	18	first	first	ADV
finefocus-541	69	19	recapitulated	recapitulate	VERB
finefocus-541	69	20	the	the	DET
finefocus-541	69	21	standard	standard	NOUN
finefocus-541	69	22	in	in	ADP
finefocus-541	69	23	vitro	vitro	X
finefocus-541	69	24	infection	infection	NOUN
finefocus-541	69	25	with	with	ADP
finefocus-541	69	26	appropriate	appropriate	ADJ
finefocus-541	69	27	treatments	treatment	NOUN
finefocus-541	69	28	.	.	PUNCT
finefocus-541	70	1	we	we	PRON
finefocus-541	70	2	then	then	ADV
finefocus-541	70	3	harvested	harvest	VERB
finefocus-541	70	4	the	the	DET
finefocus-541	70	5	remaining	remain	VERB
finefocus-541	70	6	survivors	survivor	NOUN
finefocus-541	70	7	from	from	ADP
finefocus-541	70	8	the	the	DET
finefocus-541	70	9	treatment	treatment	NOUN
finefocus-541	70	10	wells	well	NOUN
finefocus-541	70	11	and	and	CCONJ
finefocus-541	70	12	plated	plate	VERB
finefocus-541	70	13	them	they	PRON
finefocus-541	70	14	on	on	ADP
finefocus-541	70	15	antibiotic	antibiotic	NOUN
finefocus-541	70	16	-	-	PUNCT
finefocus-541	70	17	infused	infuse	VERB
finefocus-541	70	18	agar	agar	NOUN
finefocus-541	70	19	.	.	PUNCT
finefocus-541	71	1	after	after	ADP
finefocus-541	71	2	incubation	incubation	NOUN
finefocus-541	71	3	,	,	PUNCT
finefocus-541	71	4	bacteria	bacteria	NOUN
finefocus-541	71	5	were	be	AUX
finefocus-541	71	6	only	only	ADV
finefocus-541	71	7	detected	detect	VERB
finefocus-541	71	8	on	on	ADP
finefocus-541	71	9	the	the	DET
finefocus-541	71	10	antibiotic	antibiotic	ADJ
finefocus-541	71	11	-	-	PUNCT
finefocus-541	71	12	free	free	ADJ
finefocus-541	71	13	control	control	NOUN
finefocus-541	71	14	plates	plate	NOUN
finefocus-541	71	15	,	,	PUNCT
finefocus-541	71	16	with	with	ADP
finefocus-541	71	17	the	the	DET
finefocus-541	71	18	greatest	great	ADJ
finefocus-541	71	19	density	density	NOUN
finefocus-541	71	20	of	of	ADP
finefocus-541	71	21	bacteria	bacteria	NOUN
finefocus-541	71	22	coming	come	VERB
finefocus-541	71	23	from	from	ADP
finefocus-541	71	24	the	the	DET
finefocus-541	71	25	untreated	untreated	ADJ
finefocus-541	71	26	control	control	NOUN
finefocus-541	71	27	wells	well	NOUN
finefocus-541	71	28	of	of	ADP
finefocus-541	71	29	the	the	DET
finefocus-541	71	30	macrophage	macrophage	ADJ
finefocus-541	71	31	infection	infection	NOUN
finefocus-541	71	32	(	(	PUNCT
finefocus-541	71	33	table	table	NOUN
finefocus-541	71	34	1	1	NUM
finefocus-541	71	35	)	)	PUNCT
finefocus-541	71	36	.	.	PUNCT
finefocus-541	72	1	ceftazidime	ceftazidime	NOUN
finefocus-541	72	2	treatment	treatment	NOUN
finefocus-541	72	3	of	of	ADP
finefocus-541	72	4	infected	infected	ADJ
finefocus-541	72	5	macrophages	macrophage	NOUN
finefocus-541	72	6	yielded	yield	VERB
finefocus-541	72	7	many	many	ADJ
finefocus-541	72	8	surviving	survive	VERB
finefocus-541	72	9	bacteria	bacteria	NOUN
finefocus-541	72	10	on	on	ADP
finefocus-541	72	11	the	the	DET
finefocus-541	72	12	antibiotic	antibiotic	ADJ
finefocus-541	72	13	-	-	PUNCT
finefocus-541	72	14	free	free	ADJ
finefocus-541	72	15	control	control	NOUN
finefocus-541	72	16	plates	plate	NOUN
finefocus-541	72	17	,	,	PUNCT
finefocus-541	72	18	and	and	CCONJ
finefocus-541	72	19	the	the	DET
finefocus-541	72	20	combination	combination	NOUN
finefocus-541	72	21	treatment	treatment	NOUN
finefocus-541	72	22	of	of	ADP
finefocus-541	72	23	ceftazidime	ceftazidime	NOUN
finefocus-541	72	24	and	and	CCONJ
finefocus-541	72	25	ifn	ifn	PROPN
finefocus-541	72	26	-	-	PUNCT
finefocus-541	72	27	γ	γ	NOUN
finefocus-541	72	28	yielded	yield	VERB
finefocus-541	72	29	no	no	DET
finefocus-541	72	30	detectable	detectable	ADJ
finefocus-541	72	31	surviving	survive	VERB
finefocus-541	72	32	bacteria	bacteria	NOUN
finefocus-541	72	33	.	.	PUNCT
finefocus-541	73	1	no	no	DET
finefocus-541	73	2	extracellular	extracellular	ADJ
finefocus-541	73	3	bacteria	bacteria	NOUN
finefocus-541	73	4	grew	grow	VERB
finefocus-541	73	5	on	on	ADP
finefocus-541	73	6	ceftazidimeinfused	ceftazidimeinfuse	VERB
finefocus-541	73	7	agar	agar	NOUN
finefocus-541	73	8	,	,	PUNCT
finefocus-541	73	9	regardless	regardless	ADV
finefocus-541	73	10	of	of	ADP
finefocus-541	73	11	the	the	DET
finefocus-541	73	12	concentration	concentration	NOUN
finefocus-541	73	13	and	and	CCONJ
finefocus-541	73	14	regardless	regardless	ADV
finefocus-541	73	15	of	of	ADP
finefocus-541	73	16	the	the	DET
finefocus-541	73	17	treatment	treatment	NOUN
finefocus-541	73	18	the	the	DET
finefocus-541	73	19	infected	infected	ADJ
finefocus-541	73	20	macrophages	macrophage	NOUN
finefocus-541	73	21	had	have	AUX
finefocus-541	73	22	received	receive	VERB
finefocus-541	73	23	.	.	PUNCT
finefocus-541	74	1	with	with	ADP
finefocus-541	74	2	these	these	DET
finefocus-541	74	3	results	result	NOUN
finefocus-541	74	4	in	in	ADP
finefocus-541	74	5	mind	mind	NOUN
finefocus-541	74	6	,	,	PUNCT
finefocus-541	74	7	we	we	PRON
finefocus-541	74	8	next	next	ADV
finefocus-541	74	9	asked	ask	VERB
finefocus-541	74	10	whether	whether	SCONJ
finefocus-541	74	11	or	or	CCONJ
finefocus-541	74	12	not	not	PART
finefocus-541	74	13	the	the	DET
finefocus-541	74	14	bacteria	bacteria	NOUN
finefocus-541	74	15	that	that	PRON
finefocus-541	74	16	were	be	AUX
finefocus-541	74	17	surviving	survive	VERB
finefocus-541	74	18	18	18	NUM
finefocus-541	74	19	-	-	SYM
finefocus-541	74	20	24	24	NUM
finefocus-541	74	21	hrs	hrs	NOUN
finefocus-541	74	22	of	of	ADP
finefocus-541	74	23	ceftazidime	ceftazidime	NOUN
finefocus-541	74	24	treatment	treatment	NOUN
finefocus-541	74	25	during	during	ADP
finefocus-541	74	26	the	the	DET
finefocus-541	74	27	macrophage	macrophage	ADJ
finefocus-541	74	28	infection	infection	NOUN
finefocus-541	74	29	were	be	AUX
finefocus-541	74	30	persister	persister	ADJ
finefocus-541	74	31	cells	cell	NOUN
finefocus-541	74	32	.	.	PUNCT
finefocus-541	75	1	123pathogens	123pathogens	PROPN
finefocus-541	75	2	&	&	CCONJ
finefocus-541	75	3	antimicrobial	antimicrobial	ADJ
finefocus-541	75	4	factors	factor	NOUN
finefocus-541	75	5	•	•	NUM
finefocus-541	75	6	table	table	NOUN
finefocus-541	75	7	1	1	NUM
finefocus-541	75	8	:	:	PUNCT
finefocus-541	75	9	remaining	remain	VERB
finefocus-541	75	10	bacteria	bacteria	NOUN
finefocus-541	75	11	fail	fail	VERB
finefocus-541	75	12	to	to	PART
finefocus-541	75	13	grow	grow	VERB
finefocus-541	75	14	on	on	ADP
finefocus-541	75	15	antibiotic	antibiotic	NOUN
finefocus-541	75	16	-	-	PUNCT
finefocus-541	75	17	infused	infuse	VERB
finefocus-541	75	18	agar	agar	NOUN
finefocus-541	75	19	.	.	PUNCT
finefocus-541	76	1	raw	raw	ADJ
finefocus-541	76	2	macrophages	macrophage	NOUN
finefocus-541	76	3	were	be	AUX
finefocus-541	76	4	infected	infect	VERB
finefocus-541	76	5	with	with	ADP
finefocus-541	76	6	b.	b.	PROPN
finefocus-541	76	7	thailandensis	thailandensis	PROPN
finefocus-541	76	8	,	,	PUNCT
finefocus-541	76	9	and	and	CCONJ
finefocus-541	76	10	treated	treat	VERB
finefocus-541	76	11	for	for	ADP
finefocus-541	76	12	18	18	NUM
finefocus-541	76	13	hours	hour	NOUN
finefocus-541	76	14	with	with	ADP
finefocus-541	76	15	ceftazidime	ceftazidime	NOUN
finefocus-541	76	16	alone	alone	ADV
finefocus-541	76	17	(	(	PUNCT
finefocus-541	76	18	10	10	NUM
finefocus-541	76	19	µg	µg	NOUN
finefocus-541	76	20	/	/	SYM
finefocus-541	76	21	ml	ml	NOUN
finefocus-541	76	22	)	)	PUNCT
finefocus-541	76	23	or	or	CCONJ
finefocus-541	76	24	the	the	DET
finefocus-541	76	25	combination	combination	NOUN
finefocus-541	76	26	of	of	ADP
finefocus-541	76	27	ceftazidime	ceftazidime	NOUN
finefocus-541	76	28	(	(	PUNCT
finefocus-541	76	29	10	10	NUM
finefocus-541	76	30	µg	µg	NOUN
finefocus-541	76	31	/	/	SYM
finefocus-541	76	32	ml	ml	NOUN
finefocus-541	76	33	)	)	PUNCT
finefocus-541	76	34	and	and	CCONJ
finefocus-541	76	35	ifn	ifn	PROPN
finefocus-541	76	36	-	-	PUNCT
finefocus-541	76	37	γ	γ	X
finefocus-541	76	38	(	(	PUNCT
finefocus-541	76	39	10	10	NUM
finefocus-541	76	40	ng	ng	PROPN
finefocus-541	76	41	/	/	SYM
finefocus-541	76	42	ml	ml	NOUN
finefocus-541	76	43	)	)	PUNCT
finefocus-541	76	44	.	.	PUNCT
finefocus-541	77	1	surviving	survive	VERB
finefocus-541	77	2	extracellular	extracellular	ADJ
finefocus-541	77	3	bacteria	bacteria	NOUN
finefocus-541	77	4	were	be	AUX
finefocus-541	77	5	then	then	ADV
finefocus-541	77	6	plated	plate	VERB
finefocus-541	77	7	onto	onto	ADP
finefocus-541	77	8	agar	agar	NOUN
finefocus-541	77	9	plates	plate	NOUN
finefocus-541	77	10	without	without	ADP
finefocus-541	77	11	antibiotic	antibiotic	ADJ
finefocus-541	77	12	,	,	PUNCT
finefocus-541	77	13	or	or	CCONJ
finefocus-541	77	14	with	with	ADP
finefocus-541	77	15	10	10	NUM
finefocus-541	77	16	µg/	µg/	NOUN
finefocus-541	77	17	ml	ml	NOUN
finefocus-541	77	18	or	or	CCONJ
finefocus-541	77	19	200	200	NUM
finefocus-541	77	20	µg	µg	ADJ
finefocus-541	77	21	/	/	SYM
finefocus-541	77	22	ml	ml	NOUN
finefocus-541	77	23	ceftazidime	ceftazidime	NOUN
finefocus-541	77	24	.	.	PUNCT
finefocus-541	78	1	this	this	DET
finefocus-541	78	2	table	table	NOUN
finefocus-541	78	3	represents	represent	VERB
finefocus-541	78	4	similar	similar	ADJ
finefocus-541	78	5	data	datum	NOUN
finefocus-541	78	6	from	from	ADP
finefocus-541	78	7	two	two	NUM
finefocus-541	78	8	independent	independent	ADJ
finefocus-541	78	9	experiments	experiment	NOUN
finefocus-541	78	10	.	.	PUNCT
finefocus-541	79	1	testing	test	VERB
finefocus-541	79	2	for	for	ADP
finefocus-541	79	3	persister	persister	ADJ
finefocus-541	79	4	cells	cell	NOUN
finefocus-541	79	5	to	to	PART
finefocus-541	79	6	determine	determine	VERB
finefocus-541	79	7	if	if	SCONJ
finefocus-541	79	8	the	the	DET
finefocus-541	79	9	remaining	remain	VERB
finefocus-541	79	10	extracellular	extracellular	ADJ
finefocus-541	79	11	b.	b.	NOUN
finefocus-541	79	12	thailandensis	thailandensis	NOUN
finefocus-541	79	13	were	be	AUX
finefocus-541	79	14	persister	persister	ADJ
finefocus-541	79	15	cells	cell	NOUN
finefocus-541	79	16	,	,	PUNCT
finefocus-541	79	17	we	we	PRON
finefocus-541	79	18	again	again	ADV
finefocus-541	79	19	harvested	harvest	VERB
finefocus-541	79	20	the	the	DET
finefocus-541	79	21	bacteria	bacteria	NOUN
finefocus-541	79	22	from	from	ADP
finefocus-541	79	23	the	the	DET
finefocus-541	79	24	end	end	NOUN
finefocus-541	79	25	of	of	ADP
finefocus-541	79	26	the	the	DET
finefocus-541	79	27	macrophage	macrophage	ADJ
finefocus-541	79	28	infection	infection	NOUN
finefocus-541	79	29	to	to	PART
finefocus-541	79	30	determine	determine	VERB
finefocus-541	79	31	their	their	PRON
finefocus-541	79	32	sensitivity	sensitivity	NOUN
finefocus-541	79	33	.	.	PUNCT
finefocus-541	80	1	after	after	ADP
finefocus-541	80	2	18	18	NUM
finefocus-541	80	3	hours	hour	NOUN
finefocus-541	80	4	of	of	ADP
finefocus-541	80	5	ceftazidime	ceftazidime	NOUN
finefocus-541	80	6	treatment	treatment	NOUN
finefocus-541	80	7	(	(	PUNCT
finefocus-541	80	8	10	10	NUM
finefocus-541	80	9	µg	µg	NOUN
finefocus-541	80	10	/	/	SYM
finefocus-541	80	11	ml	ml	NOUN
finefocus-541	80	12	)	)	PUNCT
finefocus-541	80	13	of	of	ADP
finefocus-541	80	14	the	the	DET
finefocus-541	80	15	infected	infected	ADJ
finefocus-541	80	16	macrophages	macrophage	NOUN
finefocus-541	80	17	,	,	PUNCT
finefocus-541	80	18	the	the	DET
finefocus-541	80	19	remaining	remain	VERB
finefocus-541	80	20	extracellular	extracellular	ADJ
finefocus-541	80	21	bacteria	bacteria	NOUN
finefocus-541	80	22	were	be	AUX
finefocus-541	80	23	separated	separate	VERB
finefocus-541	80	24	from	from	ADP
finefocus-541	80	25	the	the	DET
finefocus-541	80	26	macrophages	macrophage	NOUN
finefocus-541	80	27	,	,	PUNCT
finefocus-541	80	28	processed	process	VERB
finefocus-541	80	29	,	,	PUNCT
finefocus-541	80	30	and	and	CCONJ
finefocus-541	80	31	re	re	VERB
finefocus-541	80	32	-	-	VERB
finefocus-541	80	33	subjected	subject	VERB
finefocus-541	80	34	to	to	ADP
finefocus-541	80	35	a	a	DET
finefocus-541	80	36	higher	high	ADJ
finefocus-541	80	37	concentration	concentration	NOUN
finefocus-541	80	38	of	of	ADP
finefocus-541	80	39	ceftazidime	ceftazidime	NOUN
finefocus-541	80	40	to	to	PART
finefocus-541	80	41	identify	identify	VERB
finefocus-541	80	42	persister	persister	ADJ
finefocus-541	80	43	cells	cell	NOUN
finefocus-541	80	44	.	.	PUNCT
finefocus-541	81	1	at	at	ADP
finefocus-541	81	2	different	different	ADJ
finefocus-541	81	3	time	time	NOUN
finefocus-541	81	4	points	point	NOUN
finefocus-541	81	5	well	well	ADJ
finefocus-541	81	6	contents	content	NOUN
finefocus-541	81	7	were	be	AUX
finefocus-541	81	8	serially	serially	ADV
finefocus-541	81	9	diluted	dilute	VERB
finefocus-541	81	10	and	and	CCONJ
finefocus-541	81	11	plated	plate	VERB
finefocus-541	81	12	onto	onto	ADP
finefocus-541	81	13	lb	lb	DET
finefocus-541	81	14	agar	agar	NOUN
finefocus-541	81	15	.	.	PUNCT
finefocus-541	82	1	as	as	SCONJ
finefocus-541	82	2	shown	show	VERB
finefocus-541	82	3	in	in	ADP
finefocus-541	82	4	(	(	PUNCT
finefocus-541	82	5	figure	figure	NOUN
finefocus-541	82	6	1	1	NUM
finefocus-541	82	7	)	)	PUNCT
finefocus-541	82	8	,	,	PUNCT
finefocus-541	82	9	the	the	DET
finefocus-541	82	10	bacteria	bacteria	NOUN
finefocus-541	82	11	that	that	PRON
finefocus-541	82	12	had	have	AUX
finefocus-541	82	13	previously	previously	ADV
finefocus-541	82	14	survived	survive	VERB
finefocus-541	82	15	antibiotic	antibiotic	ADJ
finefocus-541	82	16	treatment	treatment	NOUN
finefocus-541	82	17	in	in	ADP
finefocus-541	82	18	the	the	DET
finefocus-541	82	19	presence	presence	NOUN
finefocus-541	82	20	of	of	ADP
finefocus-541	82	21	the	the	DET
finefocus-541	82	22	macrophages	macrophage	NOUN
finefocus-541	82	23	were	be	AUX
finefocus-541	82	24	now	now	ADV
finefocus-541	82	25	killed	kill	VERB
finefocus-541	82	26	by	by	ADP
finefocus-541	82	27	high	high	ADJ
finefocus-541	82	28	doses	dose	NOUN
finefocus-541	82	29	of	of	ADP
finefocus-541	82	30	ceftazidime	ceftazidime	NOUN
finefocus-541	82	31	(	(	PUNCT
finefocus-541	82	32	200	200	NUM
finefocus-541	82	33	µg	µg	NOUN
finefocus-541	82	34	/	/	SYM
finefocus-541	82	35	ml	ml	NOUN
finefocus-541	82	36	)	)	PUNCT
finefocus-541	82	37	over	over	ADP
finefocus-541	82	38	the	the	DET
finefocus-541	82	39	48	48	NUM
finefocus-541	82	40	hour	hour	NOUN
finefocus-541	82	41	time	time	NOUN
finefocus-541	82	42	frame	frame	NOUN
finefocus-541	82	43	,	,	PUNCT
finefocus-541	82	44	with	with	ADP
finefocus-541	82	45	most	most	ADJ
finefocus-541	82	46	of	of	ADP
finefocus-541	82	47	the	the	DET
finefocus-541	82	48	killing	killing	NOUN
finefocus-541	82	49	occurring	occur	VERB
finefocus-541	82	50	by	by	ADP
finefocus-541	82	51	24	24	NUM
finefocus-541	82	52	hours	hour	NOUN
finefocus-541	82	53	.	.	PUNCT
finefocus-541	83	1	from	from	ADP
finefocus-541	83	2	time	time	NOUN
finefocus-541	83	3	point	point	NOUN
finefocus-541	83	4	0	0	NUM
finefocus-541	83	5	to	to	ADP
finefocus-541	83	6	3	3	NUM
finefocus-541	83	7	hours	hour	NOUN
finefocus-541	83	8	,	,	PUNCT
finefocus-541	83	9	there	there	PRON
finefocus-541	83	10	was	be	VERB
finefocus-541	83	11	no	no	DET
finefocus-541	83	12	statistical	statistical	ADJ
finefocus-541	83	13	difference	difference	NOUN
finefocus-541	83	14	in	in	ADP
finefocus-541	83	15	how	how	SCONJ
finefocus-541	83	16	many	many	ADJ
finefocus-541	83	17	bacteria	bacteria	NOUN
finefocus-541	83	18	were	be	AUX
finefocus-541	83	19	killed	kill	VERB
finefocus-541	83	20	by	by	ADP
finefocus-541	83	21	the	the	DET
finefocus-541	83	22	antibiotic	antibiotic	NOUN
finefocus-541	83	23	.	.	PUNCT
finefocus-541	84	1	there	there	PRON
finefocus-541	84	2	was	be	VERB
finefocus-541	84	3	however	however	ADV
finefocus-541	84	4	,	,	PUNCT
finefocus-541	84	5	statistically	statistically	ADV
finefocus-541	84	6	significant	significant	ADJ
finefocus-541	84	7	killing	killing	NOUN
finefocus-541	84	8	at	at	ADP
finefocus-541	84	9	the	the	DET
finefocus-541	84	10	time	time	NOUN
finefocus-541	84	11	point	point	NOUN
finefocus-541	84	12	for	for	ADP
finefocus-541	84	13	24	24	NUM
finefocus-541	84	14	hours	hour	NOUN
finefocus-541	84	15	(	(	PUNCT
finefocus-541	84	16	p<0.01	p<0.01	PROPN
finefocus-541	84	17	)	)	PUNCT
finefocus-541	84	18	.	.	PUNCT
finefocus-541	85	1	by	by	ADP
finefocus-541	85	2	48	48	NUM
finefocus-541	85	3	hours	hour	NOUN
finefocus-541	85	4	,	,	PUNCT
finefocus-541	85	5	we	we	PRON
finefocus-541	85	6	were	be	AUX
finefocus-541	85	7	unable	unable	ADJ
finefocus-541	85	8	to	to	PART
finefocus-541	85	9	detect	detect	VERB
finefocus-541	85	10	any	any	DET
finefocus-541	85	11	viable	viable	ADJ
finefocus-541	85	12	b.	b.	NOUN
finefocus-541	85	13	thailandensis	thailandensis	NOUN
finefocus-541	85	14	cells	cell	NOUN
finefocus-541	85	15	(	(	PUNCT
finefocus-541	85	16	p<0.001	p<0.001	PROPN
finefocus-541	85	17	)	)	PUNCT
finefocus-541	85	18	,	,	PUNCT
finefocus-541	85	19	indicating	indicate	VERB
finefocus-541	85	20	that	that	SCONJ
finefocus-541	85	21	all	all	DET
finefocus-541	85	22	bacteria	bacteria	NOUN
finefocus-541	85	23	had	have	AUX
finefocus-541	85	24	been	be	AUX
finefocus-541	85	25	killed	kill	VERB
finefocus-541	85	26	.	.	PUNCT
finefocus-541	86	1	124•	124•	NUM
finefocus-541	86	2	fine	fine	ADJ
finefocus-541	86	3	focus	focus	NOUN
finefocus-541	86	4	,	,	PUNCT
finefocus-541	86	5	vol	vol	NOUN
finefocus-541	86	6	.	.	PUNCT
finefocus-541	86	7	4(1	4(1	X
finefocus-541	86	8	)	)	PUNCT
finefocus-541	86	9	figure	figure	VERB
finefocus-541	86	10	1	1	NUM
finefocus-541	86	11	:	:	PUNCT
finefocus-541	86	12	after	after	ADP
finefocus-541	86	13	18	18	NUM
finefocus-541	86	14	hour	hour	NOUN
finefocus-541	86	15	macrophage	macrophage	ADJ
finefocus-541	86	16	infection	infection	NOUN
finefocus-541	86	17	,	,	PUNCT
finefocus-541	86	18	remaining	remain	VERB
finefocus-541	86	19	extracellular	extracellular	ADJ
finefocus-541	86	20	bacteria	bacteria	NOUN
finefocus-541	86	21	are	be	AUX
finefocus-541	86	22	still	still	ADV
finefocus-541	86	23	sensitive	sensitive	ADJ
finefocus-541	86	24	to	to	ADP
finefocus-541	86	25	high	high	ADJ
finefocus-541	86	26	doses	dose	NOUN
finefocus-541	86	27	of	of	ADP
finefocus-541	86	28	antibiotic	antibiotic	ADJ
finefocus-541	86	29	.	.	PUNCT
finefocus-541	87	1	raw	raw	ADJ
finefocus-541	87	2	cells	cell	NOUN
finefocus-541	87	3	were	be	AUX
finefocus-541	87	4	infected	infect	VERB
finefocus-541	87	5	with	with	ADP
finefocus-541	87	6	b.	b.	PROPN
finefocus-541	87	7	thailandensis	thailandensis	PROPN
finefocus-541	87	8	.	.	PUNCT
finefocus-541	88	1	after	after	ADP
finefocus-541	88	2	18	18	NUM
finefocus-541	88	3	hours	hour	NOUN
finefocus-541	88	4	of	of	ADP
finefocus-541	88	5	treatment	treatment	NOUN
finefocus-541	88	6	with	with	ADP
finefocus-541	88	7	10	10	NUM
finefocus-541	88	8	µg	µg	ADJ
finefocus-541	88	9	/	/	SYM
finefocus-541	88	10	ml	ml	NOUN
finefocus-541	88	11	ceftazidime	ceftazidime	NOUN
finefocus-541	88	12	,	,	PUNCT
finefocus-541	88	13	the	the	DET
finefocus-541	88	14	surviving	survive	VERB
finefocus-541	88	15	extracellular	extracellular	ADJ
finefocus-541	88	16	bacteria	bacteria	NOUN
finefocus-541	88	17	were	be	AUX
finefocus-541	88	18	removed	remove	VERB
finefocus-541	88	19	,	,	PUNCT
finefocus-541	88	20	washed	wash	VERB
finefocus-541	88	21	,	,	PUNCT
finefocus-541	88	22	and	and	CCONJ
finefocus-541	88	23	re	re	VERB
finefocus-541	88	24	-	-	VERB
finefocus-541	88	25	subjected	subject	VERB
finefocus-541	88	26	to	to	ADP
finefocus-541	88	27	ceftazidime	ceftazidime	NOUN
finefocus-541	88	28	at	at	ADP
finefocus-541	88	29	100x	100x	NUM
finefocus-541	88	30	the	the	DET
finefocus-541	88	31	mic	mic	NOUN
finefocus-541	88	32	(	(	PUNCT
finefocus-541	88	33	200	200	NUM
finefocus-541	88	34	µg	µg	NOUN
finefocus-541	88	35	/	/	SYM
finefocus-541	88	36	ml	ml	NOUN
finefocus-541	88	37	)	)	PUNCT
finefocus-541	88	38	in	in	ADP
finefocus-541	88	39	a	a	DET
finefocus-541	88	40	macrophage	macrophage	ADJ
finefocus-541	88	41	-	-	PUNCT
finefocus-541	88	42	free	free	ADJ
finefocus-541	88	43	system	system	NOUN
finefocus-541	88	44	.	.	PUNCT
finefocus-541	89	1	bacterial	bacterial	ADJ
finefocus-541	89	2	density	density	NOUN
finefocus-541	89	3	was	be	AUX
finefocus-541	89	4	determined	determine	VERB
finefocus-541	89	5	at	at	ADP
finefocus-541	89	6	time	time	NOUN
finefocus-541	89	7	points	point	NOUN
finefocus-541	89	8	0	0	NUM
finefocus-541	89	9	,	,	PUNCT
finefocus-541	89	10	1	1	NUM
finefocus-541	89	11	,	,	PUNCT
finefocus-541	89	12	2	2	NUM
finefocus-541	89	13	,	,	PUNCT
finefocus-541	89	14	3	3	NUM
finefocus-541	89	15	,	,	PUNCT
finefocus-541	89	16	24	24	NUM
finefocus-541	89	17	,	,	PUNCT
finefocus-541	89	18	and	and	CCONJ
finefocus-541	89	19	48	48	NUM
finefocus-541	89	20	hours	hour	NOUN
finefocus-541	89	21	by	by	ADP
finefocus-541	89	22	plating	plating	NOUN
finefocus-541	89	23	dilutions	dilution	NOUN
finefocus-541	89	24	of	of	ADP
finefocus-541	89	25	the	the	DET
finefocus-541	89	26	well	well	ADJ
finefocus-541	89	27	contents	content	NOUN
finefocus-541	89	28	.	.	PUNCT
finefocus-541	90	1	data	datum	NOUN
finefocus-541	90	2	is	be	AUX
finefocus-541	90	3	representative	representative	NOUN
finefocus-541	90	4	of	of	ADP
finefocus-541	90	5	three	three	NUM
finefocus-541	90	6	similar	similar	ADJ
finefocus-541	90	7	and	and	CCONJ
finefocus-541	90	8	independent	independent	ADJ
finefocus-541	90	9	experiments	experiment	NOUN
finefocus-541	90	10	that	that	PRON
finefocus-541	90	11	showed	show	VERB
finefocus-541	90	12	similar	similar	ADJ
finefocus-541	90	13	trends	trend	NOUN
finefocus-541	90	14	in	in	ADP
finefocus-541	90	15	killing	kill	VERB
finefocus-541	90	16	.	.	PUNCT
finefocus-541	91	1	means	mean	NOUN
finefocus-541	91	2	and	and	CCONJ
finefocus-541	91	3	sem	sem	NOUN
finefocus-541	91	4	were	be	AUX
finefocus-541	91	5	plotted	plot	VERB
finefocus-541	91	6	for	for	ADP
finefocus-541	91	7	each	each	DET
finefocus-541	91	8	time	time	NOUN
finefocus-541	91	9	point	point	NOUN
finefocus-541	91	10	.	.	PUNCT
finefocus-541	92	1	one	one	NUM
finefocus-541	92	2	-	-	PUNCT
finefocus-541	92	3	way	way	NOUN
finefocus-541	92	4	anova	anova	PROPN
finefocus-541	92	5	was	be	AUX
finefocus-541	92	6	used	use	VERB
finefocus-541	92	7	to	to	PART
finefocus-541	92	8	determine	determine	VERB
finefocus-541	92	9	statistically	statistically	ADV
finefocus-541	92	10	significant	significant	ADJ
finefocus-541	92	11	differences	difference	NOUN
finefocus-541	92	12	from	from	ADP
finefocus-541	92	13	time	time	NOUN
finefocus-541	92	14	point	point	NOUN
finefocus-541	92	15	0	0	NUM
finefocus-541	92	16	,	,	PUNCT
finefocus-541	92	17	with	with	ADP
finefocus-541	92	18	*	*	NOUN
finefocus-541	92	19	*	*	PUNCT
finefocus-541	92	20	indicating	indicate	VERB
finefocus-541	92	21	p	p	X
finefocus-541	92	22	<	<	X
finefocus-541	92	23	0.01	0.01	NUM
finefocus-541	92	24	,	,	PUNCT
finefocus-541	92	25	and	and	CCONJ
finefocus-541	92	26	*	*	PUNCT
finefocus-541	92	27	*	*	PUNCT
finefocus-541	92	28	*	*	AUX
finefocus-541	92	29	indicating	indicate	VERB
finefocus-541	92	30	p	p	X
finefocus-541	92	31	<	<	X
finefocus-541	92	32	0.001	0.001	NUM
finefocus-541	92	33	.	.	PUNCT
finefocus-541	93	1	discussion	discussion	NOUN
finefocus-541	93	2	the	the	DET
finefocus-541	93	3	purpose	purpose	NOUN
finefocus-541	93	4	of	of	ADP
finefocus-541	93	5	these	these	DET
finefocus-541	93	6	experiments	experiment	NOUN
finefocus-541	93	7	was	be	AUX
finefocus-541	93	8	to	to	PART
finefocus-541	93	9	determine	determine	VERB
finefocus-541	93	10	if	if	SCONJ
finefocus-541	93	11	the	the	DET
finefocus-541	93	12	extracellular	extracellular	ADJ
finefocus-541	93	13	bacteria	bacteria	NOUN
finefocus-541	93	14	that	that	PRON
finefocus-541	93	15	were	be	AUX
finefocus-541	93	16	surviving	survive	VERB
finefocus-541	93	17	18	18	NUM
finefocus-541	93	18	hours	hour	NOUN
finefocus-541	93	19	of	of	ADP
finefocus-541	93	20	treatment	treatment	NOUN
finefocus-541	93	21	with	with	ADP
finefocus-541	93	22	ceftazidime	ceftazidime	NOUN
finefocus-541	93	23	in	in	ADP
finefocus-541	93	24	the	the	DET
finefocus-541	93	25	macrophage	macrophage	ADJ
finefocus-541	93	26	infection	infection	NOUN
finefocus-541	93	27	model	model	NOUN
finefocus-541	93	28	were	be	AUX
finefocus-541	93	29	classically	classically	ADV
finefocus-541	93	30	resistant	resistant	ADJ
finefocus-541	93	31	or	or	CCONJ
finefocus-541	93	32	if	if	SCONJ
finefocus-541	93	33	they	they	PRON
finefocus-541	93	34	were	be	AUX
finefocus-541	93	35	considered	consider	VERB
finefocus-541	93	36	to	to	PART
finefocus-541	93	37	be	be	AUX
finefocus-541	93	38	persister	persister	ADJ
finefocus-541	93	39	cells	cell	NOUN
finefocus-541	93	40	.	.	PUNCT
finefocus-541	94	1	similar	similar	ADJ
finefocus-541	94	2	to	to	ADP
finefocus-541	94	3	titball	titball	PROPN
finefocus-541	94	4	et	et	NOUN
finefocus-541	94	5	.	.	PUNCT
finefocus-541	95	1	al	al	PROPN
finefocus-541	95	2	.	.	PUNCT
finefocus-541	96	1	we	we	PRON
finefocus-541	96	2	plated	plate	VERB
finefocus-541	96	3	the	the	DET
finefocus-541	96	4	bacteria	bacteria	NOUN
finefocus-541	96	5	onto	onto	ADP
finefocus-541	96	6	antibiotic	antibiotic	NOUN
finefocus-541	96	7	-	-	PUNCT
finefocus-541	96	8	infused	infuse	VERB
finefocus-541	96	9	media	medium	NOUN
finefocus-541	96	10	to	to	PART
finefocus-541	96	11	test	test	VERB
finefocus-541	96	12	for	for	ADP
finefocus-541	96	13	antibiotic	antibiotic	ADJ
finefocus-541	96	14	resistance	resistance	NOUN
finefocus-541	96	15	due	due	ADP
finefocus-541	96	16	to	to	ADP
finefocus-541	96	17	spontaneous	spontaneous	ADJ
finefocus-541	96	18	mutations	mutation	NOUN
finefocus-541	96	19	(	(	PUNCT
finefocus-541	96	20	2	2	NUM
finefocus-541	96	21	)	)	PUNCT
finefocus-541	96	22	.	.	PUNCT
finefocus-541	97	1	in	in	ADP
finefocus-541	97	2	table	table	NOUN
finefocus-541	97	3	1	1	NUM
finefocus-541	97	4	,	,	PUNCT
finefocus-541	97	5	we	we	PRON
finefocus-541	97	6	showed	show	VERB
finefocus-541	97	7	a	a	DET
finefocus-541	97	8	lack	lack	NOUN
finefocus-541	97	9	of	of	ADP
finefocus-541	97	10	growth	growth	NOUN
finefocus-541	97	11	on	on	ADP
finefocus-541	97	12	the	the	DET
finefocus-541	97	13	antibiotic	antibiotic	NOUN
finefocus-541	97	14	-	-	PUNCT
finefocus-541	97	15	infused	infuse	VERB
finefocus-541	97	16	plates	plate	NOUN
finefocus-541	97	17	,	,	PUNCT
finefocus-541	97	18	which	which	PRON
finefocus-541	97	19	serves	serve	VERB
finefocus-541	97	20	as	as	ADP
finefocus-541	97	21	evidence	evidence	NOUN
finefocus-541	97	22	that	that	SCONJ
finefocus-541	97	23	the	the	DET
finefocus-541	97	24	extracellular	extracellular	ADJ
finefocus-541	97	25	bacteria	bacteria	NOUN
finefocus-541	97	26	were	be	AUX
finefocus-541	97	27	not	not	PART
finefocus-541	97	28	classically	classically	ADV
finefocus-541	97	29	resistant	resistant	ADJ
finefocus-541	97	30	.	.	PUNCT
finefocus-541	98	1	in	in	ADP
finefocus-541	98	2	classical	classical	ADJ
finefocus-541	98	3	resistance	resistance	NOUN
finefocus-541	98	4	,	,	PUNCT
finefocus-541	98	5	the	the	DET
finefocus-541	98	6	125pathogens	125pathogens	PROPN
finefocus-541	98	7	&	&	CCONJ
finefocus-541	98	8	antimicrobial	antimicrobial	ADJ
finefocus-541	98	9	factors	factor	NOUN
finefocus-541	98	10	•	•	ADP
finefocus-541	98	11	progeny	progeny	NOUN
finefocus-541	98	12	of	of	ADP
finefocus-541	98	13	the	the	DET
finefocus-541	98	14	resistant	resistant	ADJ
finefocus-541	98	15	cells	cell	NOUN
finefocus-541	98	16	would	would	AUX
finefocus-541	98	17	also	also	ADV
finefocus-541	98	18	be	be	AUX
finefocus-541	98	19	resistant	resistant	ADJ
finefocus-541	98	20	,	,	PUNCT
finefocus-541	98	21	therefore	therefore	ADV
finefocus-541	98	22	we	we	PRON
finefocus-541	98	23	would	would	AUX
finefocus-541	98	24	expect	expect	VERB
finefocus-541	98	25	to	to	PART
finefocus-541	98	26	see	see	VERB
finefocus-541	98	27	whole	whole	ADJ
finefocus-541	98	28	colonies	colony	NOUN
finefocus-541	98	29	of	of	ADP
finefocus-541	98	30	antibiotic	antibiotic	ADJ
finefocus-541	98	31	-	-	PUNCT
finefocus-541	98	32	resistant	resistant	ADJ
finefocus-541	98	33	bacteria	bacteria	NOUN
finefocus-541	98	34	on	on	ADP
finefocus-541	98	35	the	the	DET
finefocus-541	98	36	plates	plate	NOUN
finefocus-541	98	37	infused	infuse	VERB
finefocus-541	98	38	with	with	ADP
finefocus-541	98	39	antibiotic	antibiotic	ADJ
finefocus-541	98	40	concentrations	concentration	NOUN
finefocus-541	98	41	above	above	ADP
finefocus-541	98	42	the	the	DET
finefocus-541	98	43	mic	mic	NOUN
finefocus-541	98	44	.	.	PUNCT
finefocus-541	99	1	instead	instead	ADV
finefocus-541	99	2	,	,	PUNCT
finefocus-541	99	3	we	we	PRON
finefocus-541	99	4	were	be	AUX
finefocus-541	99	5	only	only	ADV
finefocus-541	99	6	able	able	ADJ
finefocus-541	99	7	to	to	PART
finefocus-541	99	8	see	see	VERB
finefocus-541	99	9	growth	growth	NOUN
finefocus-541	99	10	on	on	ADP
finefocus-541	99	11	the	the	DET
finefocus-541	99	12	antibiotic	antibiotic	ADJ
finefocus-541	99	13	-	-	PUNCT
finefocus-541	99	14	free	free	ADJ
finefocus-541	99	15	control	control	NOUN
finefocus-541	99	16	plates	plate	NOUN
finefocus-541	99	17	.	.	PUNCT
finefocus-541	100	1	since	since	SCONJ
finefocus-541	100	2	we	we	PRON
finefocus-541	100	3	did	do	AUX
finefocus-541	100	4	not	not	PART
finefocus-541	100	5	plate	plate	VERB
finefocus-541	100	6	all	all	PRON
finefocus-541	100	7	of	of	ADP
finefocus-541	100	8	the	the	DET
finefocus-541	100	9	volume	volume	NOUN
finefocus-541	100	10	from	from	ADP
finefocus-541	100	11	each	each	PRON
finefocus-541	100	12	of	of	ADP
finefocus-541	100	13	the	the	DET
finefocus-541	100	14	treated	treat	VERB
finefocus-541	100	15	wells	well	NOUN
finefocus-541	100	16	of	of	ADP
finefocus-541	100	17	the	the	DET
finefocus-541	100	18	macrophage	macrophage	ADJ
finefocus-541	100	19	infection	infection	NOUN
finefocus-541	100	20	,	,	PUNCT
finefocus-541	100	21	there	there	PRON
finefocus-541	100	22	is	be	VERB
finefocus-541	100	23	also	also	ADV
finefocus-541	100	24	a	a	DET
finefocus-541	100	25	limit	limit	NOUN
finefocus-541	100	26	of	of	ADP
finefocus-541	100	27	detection	detection	NOUN
finefocus-541	100	28	to	to	ADP
finefocus-541	100	29	our	our	PRON
finefocus-541	100	30	assay	assay	NOUN
finefocus-541	100	31	,	,	PUNCT
finefocus-541	100	32	and	and	CCONJ
finefocus-541	100	33	we	we	PRON
finefocus-541	100	34	can	can	AUX
finefocus-541	100	35	not	not	PART
finefocus-541	100	36	say	say	VERB
finefocus-541	100	37	with	with	ADP
finefocus-541	100	38	certainty	certainty	NOUN
finefocus-541	100	39	that	that	SCONJ
finefocus-541	100	40	the	the	DET
finefocus-541	100	41	well	well	ADJ
finefocus-541	100	42	contents	content	NOUN
finefocus-541	100	43	did	do	AUX
finefocus-541	100	44	not	not	PART
finefocus-541	100	45	contain	contain	VERB
finefocus-541	100	46	any	any	DET
finefocus-541	100	47	antibiotic	antibiotic	ADJ
finefocus-541	100	48	resistant	resistant	ADJ
finefocus-541	100	49	bacteria	bacteria	NOUN
finefocus-541	100	50	.	.	PUNCT
finefocus-541	101	1	regardless	regardless	ADV
finefocus-541	101	2	,	,	PUNCT
finefocus-541	101	3	we	we	PRON
finefocus-541	101	4	were	be	AUX
finefocus-541	101	5	able	able	ADJ
finefocus-541	101	6	to	to	PART
finefocus-541	101	7	determine	determine	VERB
finefocus-541	101	8	that	that	SCONJ
finefocus-541	101	9	the	the	DET
finefocus-541	101	10	majority	majority	NOUN
finefocus-541	101	11	of	of	ADP
finefocus-541	101	12	the	the	DET
finefocus-541	101	13	extracellular	extracellular	ADJ
finefocus-541	101	14	bacteria	bacteria	NOUN
finefocus-541	101	15	are	be	AUX
finefocus-541	101	16	not	not	PART
finefocus-541	101	17	resistant	resistant	ADJ
finefocus-541	101	18	.	.	PUNCT
finefocus-541	102	1	previous	previous	ADJ
finefocus-541	102	2	studies	study	NOUN
finefocus-541	102	3	found	find	VERB
finefocus-541	102	4	low	low	ADJ
finefocus-541	102	5	bacterial	bacterial	ADJ
finefocus-541	102	6	burden	burden	NOUN
finefocus-541	102	7	in	in	ADP
finefocus-541	102	8	the	the	DET
finefocus-541	102	9	extracellular	extracellular	ADJ
finefocus-541	102	10	compartment	compartment	NOUN
finefocus-541	102	11	following	follow	VERB
finefocus-541	102	12	macrophage	macrophage	ADJ
finefocus-541	102	13	treatment	treatment	NOUN
finefocus-541	102	14	with	with	ADP
finefocus-541	102	15	ceftazidime	ceftazidime	NOUN
finefocus-541	102	16	and	and	CCONJ
finefocus-541	102	17	ifn	ifn	PROPN
finefocus-541	102	18	-	-	PUNCT
finefocus-541	102	19	γ	γ	X
finefocus-541	102	20	(	(	PUNCT
finefocus-541	102	21	10	10	NUM
finefocus-541	102	22	)	)	PUNCT
finefocus-541	102	23	.	.	PUNCT
finefocus-541	103	1	here	here	ADV
finefocus-541	103	2	we	we	PRON
finefocus-541	103	3	were	be	AUX
finefocus-541	103	4	unable	unable	ADJ
finefocus-541	103	5	to	to	PART
finefocus-541	103	6	detect	detect	VERB
finefocus-541	103	7	any	any	DET
finefocus-541	103	8	extracellular	extracellular	ADJ
finefocus-541	103	9	bacteria	bacteria	NOUN
finefocus-541	103	10	from	from	ADP
finefocus-541	103	11	the	the	DET
finefocus-541	103	12	wells	well	NOUN
finefocus-541	103	13	of	of	ADP
finefocus-541	103	14	infected	infected	ADJ
finefocus-541	103	15	macrophages	macrophage	NOUN
finefocus-541	103	16	that	that	PRON
finefocus-541	103	17	had	have	AUX
finefocus-541	103	18	received	receive	VERB
finefocus-541	103	19	the	the	DET
finefocus-541	103	20	combination	combination	NOUN
finefocus-541	103	21	treatment	treatment	NOUN
finefocus-541	103	22	group	group	NOUN
finefocus-541	103	23	,	,	PUNCT
finefocus-541	103	24	which	which	PRON
finefocus-541	103	25	indicates	indicate	VERB
finefocus-541	103	26	that	that	SCONJ
finefocus-541	103	27	this	this	DET
finefocus-541	103	28	population	population	NOUN
finefocus-541	103	29	of	of	ADP
finefocus-541	103	30	bacteria	bacteria	NOUN
finefocus-541	103	31	is	be	AUX
finefocus-541	103	32	very	very	ADV
finefocus-541	103	33	small	small	ADJ
finefocus-541	103	34	,	,	PUNCT
finefocus-541	103	35	and	and	CCONJ
finefocus-541	103	36	provides	provide	VERB
finefocus-541	103	37	further	further	ADJ
finefocus-541	103	38	evidence	evidence	NOUN
finefocus-541	103	39	that	that	SCONJ
finefocus-541	103	40	the	the	DET
finefocus-541	103	41	combination	combination	NOUN
finefocus-541	103	42	therapy	therapy	NOUN
finefocus-541	103	43	may	may	AUX
finefocus-541	103	44	provide	provide	VERB
finefocus-541	103	45	significantly	significantly	ADV
finefocus-541	103	46	more	more	ADJ
finefocus-541	103	47	protection	protection	NOUN
finefocus-541	103	48	than	than	ADP
finefocus-541	103	49	the	the	DET
finefocus-541	103	50	antibiotic	antibiotic	NOUN
finefocus-541	103	51	alone	alone	ADV
finefocus-541	103	52	.	.	PUNCT
finefocus-541	104	1	while	while	SCONJ
finefocus-541	104	2	table	table	NOUN
finefocus-541	104	3	1	1	NUM
finefocus-541	104	4	shows	show	VERB
finefocus-541	104	5	evidence	evidence	NOUN
finefocus-541	104	6	that	that	SCONJ
finefocus-541	104	7	the	the	DET
finefocus-541	104	8	remaining	remain	VERB
finefocus-541	104	9	bacteria	bacteria	NOUN
finefocus-541	104	10	are	be	AUX
finefocus-541	104	11	not	not	PART
finefocus-541	104	12	classically	classically	ADV
finefocus-541	104	13	resistant	resistant	ADJ
finefocus-541	104	14	,	,	PUNCT
finefocus-541	104	15	from	from	ADP
finefocus-541	104	16	these	these	DET
finefocus-541	104	17	results	result	NOUN
finefocus-541	104	18	alone	alone	ADV
finefocus-541	104	19	,	,	PUNCT
finefocus-541	104	20	we	we	PRON
finefocus-541	104	21	can	can	AUX
finefocus-541	104	22	not	not	PART
finefocus-541	104	23	rule	rule	VERB
finefocus-541	104	24	out	out	ADP
finefocus-541	104	25	the	the	DET
finefocus-541	104	26	possibility	possibility	NOUN
finefocus-541	104	27	that	that	SCONJ
finefocus-541	104	28	some	some	PRON
finefocus-541	104	29	,	,	PUNCT
finefocus-541	104	30	or	or	CCONJ
finefocus-541	104	31	many	many	ADJ
finefocus-541	104	32	,	,	PUNCT
finefocus-541	104	33	of	of	ADP
finefocus-541	104	34	the	the	DET
finefocus-541	104	35	treatment	treatment	NOUN
finefocus-541	104	36	-	-	PUNCT
finefocus-541	104	37	surviving	survive	VERB
finefocus-541	104	38	bacteria	bacteria	NOUN
finefocus-541	104	39	are	be	AUX
finefocus-541	104	40	persisters	persister	NOUN
finefocus-541	104	41	.	.	PUNCT
finefocus-541	105	1	if	if	SCONJ
finefocus-541	105	2	persisters	persister	NOUN
finefocus-541	105	3	existed	exist	VERB
finefocus-541	105	4	following	follow	VERB
finefocus-541	105	5	treatment	treatment	NOUN
finefocus-541	105	6	in	in	ADP
finefocus-541	105	7	the	the	DET
finefocus-541	105	8	macrphage	macrphage	NOUN
finefocus-541	105	9	infection	infection	NOUN
finefocus-541	105	10	model	model	NOUN
finefocus-541	105	11	,	,	PUNCT
finefocus-541	105	12	then	then	ADV
finefocus-541	105	13	they	they	PRON
finefocus-541	105	14	would	would	AUX
finefocus-541	105	15	tolerate	tolerate	VERB
finefocus-541	105	16	high	high	ADJ
finefocus-541	105	17	doses	dose	NOUN
finefocus-541	105	18	of	of	ADP
finefocus-541	105	19	antibiotics	antibiotic	NOUN
finefocus-541	105	20	on	on	ADP
finefocus-541	105	21	the	the	DET
finefocus-541	105	22	agar	agar	NOUN
finefocus-541	105	23	plates	plate	NOUN
finefocus-541	105	24	,	,	PUNCT
finefocus-541	105	25	but	but	CCONJ
finefocus-541	105	26	the	the	DET
finefocus-541	105	27	great	great	ADJ
finefocus-541	105	28	majority	majority	NOUN
finefocus-541	105	29	of	of	ADP
finefocus-541	105	30	their	their	PRON
finefocus-541	105	31	progeny	progeny	NOUN
finefocus-541	105	32	would	would	AUX
finefocus-541	105	33	be	be	AUX
finefocus-541	105	34	susceptible	susceptible	ADJ
finefocus-541	105	35	,	,	PUNCT
finefocus-541	105	36	and	and	CCONJ
finefocus-541	105	37	therefore	therefore	ADV
finefocus-541	105	38	,	,	PUNCT
finefocus-541	105	39	we	we	PRON
finefocus-541	105	40	would	would	AUX
finefocus-541	105	41	n’t	not	PART
finefocus-541	105	42	be	be	AUX
finefocus-541	105	43	able	able	ADJ
finefocus-541	105	44	to	to	PART
finefocus-541	105	45	visualize	visualize	VERB
finefocus-541	105	46	any	any	DET
finefocus-541	105	47	colonies	colony	NOUN
finefocus-541	105	48	on	on	ADP
finefocus-541	105	49	the	the	DET
finefocus-541	105	50	agar	agar	NOUN
finefocus-541	105	51	plate	plate	NOUN
finefocus-541	105	52	.	.	PUNCT
finefocus-541	106	1	since	since	SCONJ
finefocus-541	106	2	this	this	DET
finefocus-541	106	3	theory	theory	NOUN
finefocus-541	106	4	mirrored	mirror	VERB
finefocus-541	106	5	what	what	PRON
finefocus-541	106	6	we	we	PRON
finefocus-541	106	7	observed	observe	VERB
finefocus-541	106	8	,	,	PUNCT
finefocus-541	106	9	we	we	PRON
finefocus-541	106	10	hypothesized	hypothesize	VERB
finefocus-541	106	11	that	that	SCONJ
finefocus-541	106	12	some	some	DET
finefocus-541	106	13	remaining	remain	VERB
finefocus-541	106	14	bacteria	bacteria	NOUN
finefocus-541	106	15	may	may	AUX
finefocus-541	106	16	be	be	AUX
finefocus-541	106	17	persisters	persister	NOUN
finefocus-541	106	18	.	.	PUNCT
finefocus-541	107	1	we	we	PRON
finefocus-541	107	2	decided	decide	VERB
finefocus-541	107	3	to	to	PART
finefocus-541	107	4	identify	identify	VERB
finefocus-541	107	5	potential	potential	ADJ
finefocus-541	107	6	persisters	persister	NOUN
finefocus-541	107	7	as	as	SCONJ
finefocus-541	107	8	done	do	VERB
finefocus-541	107	9	previously	previously	ADV
finefocus-541	107	10	by	by	ADP
finefocus-541	107	11	treating	treat	VERB
finefocus-541	107	12	the	the	DET
finefocus-541	107	13	bacteria	bacteria	NOUN
finefocus-541	107	14	with	with	ADP
finefocus-541	107	15	a	a	DET
finefocus-541	107	16	high	high	ADJ
finefocus-541	107	17	dose	dose	NOUN
finefocus-541	107	18	of	of	ADP
finefocus-541	107	19	antibiotic	antibiotic	ADJ
finefocus-541	107	20	and	and	CCONJ
finefocus-541	107	21	looking	look	VERB
finefocus-541	107	22	for	for	ADP
finefocus-541	107	23	a	a	DET
finefocus-541	107	24	plateau	plateau	NOUN
finefocus-541	107	25	in	in	ADP
finefocus-541	107	26	the	the	DET
finefocus-541	107	27	killing	killing	NOUN
finefocus-541	107	28	over	over	ADP
finefocus-541	107	29	time	time	NOUN
finefocus-541	107	30	(	(	PUNCT
finefocus-541	107	31	4	4	NUM
finefocus-541	107	32	,	,	PUNCT
finefocus-541	107	33	9	9	NUM
finefocus-541	107	34	)	)	PUNCT
finefocus-541	107	35	.	.	PUNCT
finefocus-541	108	1	in	in	ADP
finefocus-541	108	2	such	such	ADJ
finefocus-541	108	3	cases	case	NOUN
finefocus-541	108	4	,	,	PUNCT
finefocus-541	108	5	the	the	DET
finefocus-541	108	6	bulk	bulk	NOUN
finefocus-541	108	7	of	of	ADP
finefocus-541	108	8	the	the	DET
finefocus-541	108	9	population	population	NOUN
finefocus-541	108	10	of	of	ADP
finefocus-541	108	11	bacteria	bacteria	NOUN
finefocus-541	108	12	is	be	AUX
finefocus-541	108	13	killed	kill	VERB
finefocus-541	108	14	,	,	PUNCT
finefocus-541	108	15	while	while	SCONJ
finefocus-541	108	16	the	the	DET
finefocus-541	108	17	antibiotic	antibiotic	ADJ
finefocus-541	108	18	tolerant	tolerant	ADJ
finefocus-541	108	19	persisters	persister	NOUN
finefocus-541	108	20	survive	survive	VERB
finefocus-541	108	21	.	.	PUNCT
finefocus-541	109	1	persisters	persister	NOUN
finefocus-541	109	2	are	be	AUX
finefocus-541	109	3	identified	identify	VERB
finefocus-541	109	4	as	as	ADP
finefocus-541	109	5	the	the	DET
finefocus-541	109	6	subpopulation	subpopulation	NOUN
finefocus-541	109	7	of	of	ADP
finefocus-541	109	8	surviving	survive	VERB
finefocus-541	109	9	bacteria	bacteria	NOUN
finefocus-541	109	10	after	after	SCONJ
finefocus-541	109	11	the	the	DET
finefocus-541	109	12	bulk	bulk	NOUN
finefocus-541	109	13	of	of	ADP
finefocus-541	109	14	the	the	DET
finefocus-541	109	15	population	population	NOUN
finefocus-541	109	16	has	have	AUX
finefocus-541	109	17	been	be	AUX
finefocus-541	109	18	eliminated	eliminate	VERB
finefocus-541	109	19	.	.	PUNCT
finefocus-541	110	1	graphically	graphically	ADV
finefocus-541	110	2	,	,	PUNCT
finefocus-541	110	3	the	the	DET
finefocus-541	110	4	sensitive	sensitive	ADJ
finefocus-541	110	5	majority	majority	NOUN
finefocus-541	110	6	of	of	ADP
finefocus-541	110	7	the	the	DET
finefocus-541	110	8	population	population	NOUN
finefocus-541	110	9	dies	die	VERB
finefocus-541	110	10	quickly	quickly	ADV
finefocus-541	110	11	over	over	ADP
finefocus-541	110	12	time	time	NOUN
finefocus-541	110	13	,	,	PUNCT
finefocus-541	110	14	but	but	CCONJ
finefocus-541	110	15	then	then	ADV
finefocus-541	110	16	the	the	DET
finefocus-541	110	17	killing	kill	VERB
finefocus-541	110	18	curve	curve	NOUN
finefocus-541	110	19	plateaus	plateaus	NOUN
finefocus-541	110	20	because	because	SCONJ
finefocus-541	110	21	the	the	DET
finefocus-541	110	22	remaining	remain	VERB
finefocus-541	110	23	persisters	persister	NOUN
finefocus-541	110	24	are	be	AUX
finefocus-541	110	25	tolerant	tolerant	ADJ
finefocus-541	110	26	to	to	ADP
finefocus-541	110	27	the	the	DET
finefocus-541	110	28	antibiotic	antibiotic	ADJ
finefocus-541	110	29	(	(	PUNCT
finefocus-541	110	30	4	4	NUM
finefocus-541	110	31	,	,	PUNCT
finefocus-541	110	32	9	9	NUM
finefocus-541	110	33	)	)	PUNCT
finefocus-541	110	34	.	.	PUNCT
finefocus-541	111	1	previous	previous	ADJ
finefocus-541	111	2	experiments	experiment	NOUN
finefocus-541	111	3	with	with	ADP
finefocus-541	111	4	b.	b.	PROPN
finefocus-541	111	5	pseudomallei	pseudomallei	PROPN
finefocus-541	111	6	82	82	NUM
finefocus-541	111	7	showed	show	VERB
finefocus-541	111	8	that	that	SCONJ
finefocus-541	111	9	bacteria	bacteria	NOUN
finefocus-541	111	10	exposed	expose	VERB
finefocus-541	111	11	to	to	PART
finefocus-541	111	12	cefotaxime	cefotaxime	VERB
finefocus-541	111	13	at	at	ADP
finefocus-541	111	14	100x	100x	NUM
finefocus-541	111	15	the	the	DET
finefocus-541	111	16	mic	mic	NOUN
finefocus-541	111	17	,	,	PUNCT
finefocus-541	111	18	without	without	ADP
finefocus-541	111	19	shaking	shake	VERB
finefocus-541	111	20	,	,	PUNCT
finefocus-541	111	21	were	be	AUX
finefocus-541	111	22	killed	kill	VERB
finefocus-541	111	23	modestly	modestly	ADV
finefocus-541	111	24	for	for	ADP
finefocus-541	111	25	24	24	NUM
finefocus-541	111	26	hours	hour	NOUN
finefocus-541	111	27	,	,	PUNCT
finefocus-541	111	28	after	after	ADP
finefocus-541	111	29	which	which	PRON
finefocus-541	111	30	there	there	PRON
finefocus-541	111	31	was	be	VERB
finefocus-541	111	32	no	no	DET
finefocus-541	111	33	additional	additional	ADJ
finefocus-541	111	34	killing	killing	NOUN
finefocus-541	111	35	throughout	throughout	ADP
finefocus-541	111	36	the	the	DET
finefocus-541	111	37	33	33	NUM
finefocus-541	111	38	hour	hour	NOUN
finefocus-541	111	39	experiment	experiment	NOUN
finefocus-541	111	40	(	(	PUNCT
finefocus-541	111	41	11	11	NUM
finefocus-541	111	42	)	)	PUNCT
finefocus-541	111	43	.	.	PUNCT
finefocus-541	112	1	in	in	ADP
finefocus-541	112	2	these	these	DET
finefocus-541	112	3	experiments	experiment	NOUN
finefocus-541	112	4	,	,	PUNCT
finefocus-541	112	5	there	there	PRON
finefocus-541	112	6	was	be	VERB
finefocus-541	112	7	less	less	ADJ
finefocus-541	112	8	than	than	ADP
finefocus-541	112	9	a	a	DET
finefocus-541	112	10	10	10	NUM
finefocus-541	112	11	fold	fold	ADJ
finefocus-541	112	12	overall	overall	ADJ
finefocus-541	112	13	decrease	decrease	NOUN
finefocus-541	112	14	in	in	ADP
finefocus-541	112	15	bacteria	bacteria	NOUN
finefocus-541	112	16	from	from	ADP
finefocus-541	112	17	time	time	NOUN
finefocus-541	112	18	0	0	NUM
finefocus-541	112	19	through	through	ADP
finefocus-541	112	20	the	the	DET
finefocus-541	112	21	33	33	NUM
finefocus-541	112	22	hour	hour	NOUN
finefocus-541	112	23	antibiotic	antibiotic	ADJ
finefocus-541	112	24	treatment	treatment	NOUN
finefocus-541	112	25	period	period	NOUN
finefocus-541	112	26	,	,	PUNCT
finefocus-541	112	27	showing	show	VERB
finefocus-541	112	28	tolerance	tolerance	NOUN
finefocus-541	112	29	of	of	ADP
finefocus-541	112	30	the	the	DET
finefocus-541	112	31	bacteria	bacteria	NOUN
finefocus-541	112	32	to	to	ADP
finefocus-541	112	33	the	the	DET
finefocus-541	112	34	antibiotic	antibiotic	NOUN
finefocus-541	112	35	.	.	PUNCT
finefocus-541	113	1	we	we	PRON
finefocus-541	113	2	expected	expect	VERB
finefocus-541	113	3	persister	persister	ADJ
finefocus-541	113	4	cells	cell	NOUN
finefocus-541	113	5	in	in	ADP
finefocus-541	113	6	our	our	PRON
finefocus-541	113	7	assay	assay	NOUN
finefocus-541	113	8	to	to	PART
finefocus-541	113	9	show	show	VERB
finefocus-541	113	10	a	a	DET
finefocus-541	113	11	similar	similar	ADJ
finefocus-541	113	12	trend	trend	NOUN
finefocus-541	113	13	in	in	ADP
finefocus-541	113	14	tolerance	tolerance	NOUN
finefocus-541	113	15	when	when	SCONJ
finefocus-541	113	16	exposed	expose	VERB
finefocus-541	113	17	to	to	ADP
finefocus-541	113	18	100x	100x	NUM
finefocus-541	113	19	the	the	DET
finefocus-541	113	20	mic	mic	NOUN
finefocus-541	113	21	of	of	ADP
finefocus-541	113	22	antibiotic	antibiotic	ADJ
finefocus-541	113	23	over	over	ADP
finefocus-541	113	24	a	a	DET
finefocus-541	113	25	period	period	NOUN
finefocus-541	113	26	of	of	ADP
finefocus-541	113	27	time	time	NOUN
finefocus-541	113	28	,	,	PUNCT
finefocus-541	113	29	even	even	ADV
finefocus-541	113	30	though	though	SCONJ
finefocus-541	113	31	we	we	PRON
finefocus-541	113	32	used	use	VERB
finefocus-541	113	33	b.	b.	PROPN
finefocus-541	113	34	thailandensis	thailandensis	NOUN
finefocus-541	113	35	instead	instead	ADV
finefocus-541	113	36	of	of	ADP
finefocus-541	113	37	b.	b.	PROPN
finefocus-541	113	38	pseudomallei	pseudomallei	NOUN
finefocus-541	113	39	and	and	CCONJ
finefocus-541	113	40	a	a	DET
finefocus-541	113	41	different	different	ADJ
finefocus-541	113	42	cephalosporin	cephalosporin	NOUN
finefocus-541	113	43	antibiotic	antibiotic	ADJ
finefocus-541	113	44	.	.	PUNCT
finefocus-541	114	1	if	if	SCONJ
finefocus-541	114	2	most	most	ADJ
finefocus-541	114	3	of	of	ADP
finefocus-541	114	4	the	the	DET
finefocus-541	114	5	remaining	remain	VERB
finefocus-541	114	6	bacteria	bacteria	NOUN
finefocus-541	114	7	were	be	AUX
finefocus-541	114	8	indeed	indeed	ADV
finefocus-541	114	9	persisters	persister	NOUN
finefocus-541	114	10	,	,	PUNCT
finefocus-541	114	11	we	we	PRON
finefocus-541	114	12	would	would	AUX
finefocus-541	114	13	have	have	AUX
finefocus-541	114	14	expected	expect	VERB
finefocus-541	114	15	to	to	PART
finefocus-541	114	16	see	see	VERB
finefocus-541	114	17	little	little	ADJ
finefocus-541	114	18	killing	killing	NOUN
finefocus-541	114	19	or	or	CCONJ
finefocus-541	114	20	at	at	ADP
finefocus-541	114	21	least	least	ADJ
finefocus-541	114	22	a	a	DET
finefocus-541	114	23	plateau	plateau	NOUN
finefocus-541	114	24	in	in	ADP
finefocus-541	114	25	the	the	DET
finefocus-541	114	26	killing	killing	NOUN
finefocus-541	114	27	over	over	ADP
finefocus-541	114	28	time	time	NOUN
finefocus-541	114	29	.	.	PUNCT
finefocus-541	115	1	in	in	ADP
finefocus-541	115	2	figure	figure	NOUN
finefocus-541	115	3	1	1	NUM
finefocus-541	115	4	we	we	PRON
finefocus-541	115	5	show	show	VERB
finefocus-541	115	6	that	that	SCONJ
finefocus-541	115	7	the	the	DET
finefocus-541	115	8	remaining	remain	VERB
finefocus-541	115	9	extracellular	extracellular	ADJ
finefocus-541	115	10	bacteria	bacteria	NOUN
finefocus-541	115	11	are	be	AUX
finefocus-541	115	12	still	still	ADV
finefocus-541	115	13	sensitive	sensitive	ADJ
finefocus-541	115	14	to	to	ADP
finefocus-541	115	15	high	high	ADJ
finefocus-541	115	16	doses	dose	NOUN
finefocus-541	115	17	of	of	ADP
finefocus-541	115	18	ceftazidime	ceftazidime	NOUN
finefocus-541	115	19	over	over	ADP
finefocus-541	115	20	a	a	DET
finefocus-541	115	21	24	24	NUM
finefocus-541	115	22	hour	hour	NOUN
finefocus-541	115	23	period	period	NOUN
finefocus-541	115	24	,	,	PUNCT
finefocus-541	115	25	with	with	ADP
finefocus-541	115	26	no	no	DET
finefocus-541	115	27	detectable	detectable	ADJ
finefocus-541	115	28	bacteria	bacteria	NOUN
finefocus-541	115	29	by	by	ADP
finefocus-541	115	30	48	48	NUM
finefocus-541	115	31	hours	hour	NOUN
finefocus-541	115	32	.	.	PUNCT
finefocus-541	116	1	while	while	SCONJ
finefocus-541	116	2	we	we	PRON
finefocus-541	116	3	certainly	certainly	ADV
finefocus-541	116	4	saw	see	VERB
finefocus-541	116	5	significant	significant	ADJ
finefocus-541	116	6	killing	killing	NOUN
finefocus-541	116	7	over	over	ADP
finefocus-541	116	8	time	time	NOUN
finefocus-541	116	9	,	,	PUNCT
finefocus-541	116	10	we	we	PRON
finefocus-541	116	11	can	can	AUX
finefocus-541	116	12	not	not	PART
finefocus-541	116	13	say	say	VERB
finefocus-541	116	14	definitively	definitively	ADV
finefocus-541	116	15	that	that	SCONJ
finefocus-541	116	16	the	the	DET
finefocus-541	116	17	antibiotic	antibiotic	NOUN
finefocus-541	116	18	completely	completely	ADV
finefocus-541	116	19	sterilized	sterilize	VERB
finefocus-541	116	20	the	the	DET
finefocus-541	116	21	wells	well	NOUN
finefocus-541	116	22	,	,	PUNCT
finefocus-541	116	23	due	due	ADP
finefocus-541	116	24	to	to	ADP
finefocus-541	116	25	our	our	PRON
finefocus-541	116	26	limit	limit	NOUN
finefocus-541	116	27	of	of	ADP
finefocus-541	116	28	detection	detection	NOUN
finefocus-541	116	29	.	.	PUNCT
finefocus-541	117	1	based	base	VERB
finefocus-541	117	2	on	on	ADP
finefocus-541	117	3	standardized	standardized	ADJ
finefocus-541	117	4	definitions	definition	NOUN
finefocus-541	117	5	of	of	ADP
finefocus-541	117	6	the	the	DET
finefocus-541	117	7	limit	limit	NOUN
finefocus-541	117	8	of	of	ADP
finefocus-541	117	9	detection	detection	NOUN
finefocus-541	117	10	(	(	PUNCT
finefocus-541	117	11	15	15	NUM
finefocus-541	117	12	)	)	PUNCT
finefocus-541	117	13	we	we	PRON
finefocus-541	117	14	estimate	estimate	VERB
finefocus-541	117	15	that	that	SCONJ
finefocus-541	117	16	the	the	DET
finefocus-541	117	17	number	number	NOUN
finefocus-541	117	18	of	of	ADP
finefocus-541	117	19	remaining	remain	VERB
finefocus-541	117	20	126•	126•	NUM
finefocus-541	117	21	fine	fine	ADJ
finefocus-541	117	22	focus	focus	NOUN
finefocus-541	117	23	,	,	PUNCT
finefocus-541	117	24	vol	vol	NOUN
finefocus-541	117	25	.	.	PUNCT
finefocus-541	117	26	4(1	4(1	NOUN
finefocus-541	117	27	)	)	PUNCT
finefocus-541	117	28	bacteria	bacteria	NOUN
finefocus-541	117	29	at	at	ADP
finefocus-541	117	30	48	48	NUM
finefocus-541	117	31	hours	hour	NOUN
finefocus-541	117	32	post	post	ADJ
finefocus-541	117	33	-	-	NOUN
finefocus-541	117	34	treatment	treatment	NOUN
finefocus-541	117	35	is	be	AUX
finefocus-541	117	36	<	<	X
finefocus-541	117	37	1	1	NUM
finefocus-541	117	38	cfu	cfu	NOUN
finefocus-541	117	39	/	/	SYM
finefocus-541	117	40	ml	ml	NOUN
finefocus-541	117	41	.	.	PUNCT
finefocus-541	118	1	overall	overall	ADJ
finefocus-541	118	2	,	,	PUNCT
finefocus-541	118	3	our	our	PRON
finefocus-541	118	4	evidence	evidence	NOUN
finefocus-541	118	5	has	have	AUX
finefocus-541	118	6	suggested	suggest	VERB
finefocus-541	118	7	that	that	SCONJ
finefocus-541	118	8	the	the	DET
finefocus-541	118	9	extracellular	extracellular	ADJ
finefocus-541	118	10	bacteria	bacteria	NOUN
finefocus-541	118	11	that	that	PRON
finefocus-541	118	12	survive	survive	VERB
finefocus-541	118	13	the	the	DET
finefocus-541	118	14	18	18	NUM
finefocus-541	118	15	-	-	SYM
finefocus-541	118	16	24	24	NUM
finefocus-541	118	17	hour	hour	NOUN
finefocus-541	118	18	treatments	treatment	NOUN
finefocus-541	118	19	during	during	ADP
finefocus-541	118	20	the	the	DET
finefocus-541	118	21	macrophage	macrophage	ADJ
finefocus-541	118	22	infection	infection	NOUN
finefocus-541	118	23	remain	remain	VERB
finefocus-541	118	24	sensitive	sensitive	ADJ
finefocus-541	118	25	to	to	ADP
finefocus-541	118	26	both	both	CCONJ
finefocus-541	118	27	low	low	ADJ
finefocus-541	118	28	(	(	PUNCT
finefocus-541	118	29	10	10	NUM
finefocus-541	118	30	µg	µg	NOUN
finefocus-541	118	31	/	/	SYM
finefocus-541	118	32	ml	ml	NOUN
finefocus-541	118	33	)	)	PUNCT
finefocus-541	118	34	and	and	CCONJ
finefocus-541	118	35	high	high	ADJ
finefocus-541	118	36	doses	dose	NOUN
finefocus-541	118	37	(	(	PUNCT
finefocus-541	118	38	200	200	NUM
finefocus-541	118	39	µg	µg	NOUN
finefocus-541	118	40	/	/	SYM
finefocus-541	118	41	ml	ml	NOUN
finefocus-541	118	42	)	)	PUNCT
finefocus-541	118	43	of	of	ADP
finefocus-541	118	44	the	the	DET
finefocus-541	118	45	antibiotic	antibiotic	ADJ
finefocus-541	118	46	ceftazidime	ceftazidime	NOUN
finefocus-541	118	47	.	.	PUNCT
finefocus-541	119	1	previous	previous	ADJ
finefocus-541	119	2	studies	study	NOUN
finefocus-541	119	3	have	have	AUX
finefocus-541	119	4	suggested	suggest	VERB
finefocus-541	119	5	that	that	SCONJ
finefocus-541	119	6	the	the	DET
finefocus-541	119	7	transitioning	transitioning	NOUN
finefocus-541	119	8	of	of	ADP
finefocus-541	119	9	extracellular	extracellular	PROPN
finefocus-541	119	10	b.	b.	PROPN
finefocus-541	119	11	thailandensis	thailandensis	NOUN
finefocus-541	119	12	to	to	ADP
finefocus-541	119	13	the	the	DET
finefocus-541	119	14	intracellular	intracellular	ADJ
finefocus-541	119	15	space	space	NOUN
finefocus-541	119	16	,	,	PUNCT
finefocus-541	119	17	upon	upon	SCONJ
finefocus-541	119	18	uptake	uptake	ADJ
finefocus-541	119	19	,	,	PUNCT
finefocus-541	119	20	or	or	CCONJ
finefocus-541	119	21	transitioning	transition	VERB
finefocus-541	119	22	of	of	ADP
finefocus-541	119	23	intracellular	intracellular	ADJ
finefocus-541	119	24	bacteria	bacteria	NOUN
finefocus-541	119	25	to	to	ADP
finefocus-541	119	26	the	the	DET
finefocus-541	119	27	extracellular	extracellular	ADJ
finefocus-541	119	28	space	space	NOUN
finefocus-541	119	29	,	,	PUNCT
finefocus-541	119	30	upon	upon	SCONJ
finefocus-541	119	31	macrophage	macrophage	ADJ
finefocus-541	119	32	lysis	lysis	NOUN
finefocus-541	119	33	,	,	PUNCT
finefocus-541	119	34	may	may	AUX
finefocus-541	119	35	influence	influence	VERB
finefocus-541	119	36	in	in	ADP
finefocus-541	119	37	vitro	vitro	X
finefocus-541	119	38	macrophage	macrophage	ADJ
finefocus-541	119	39	infection	infection	NOUN
finefocus-541	119	40	models	model	NOUN
finefocus-541	119	41	(	(	PUNCT
finefocus-541	119	42	10	10	NUM
finefocus-541	119	43	)	)	PUNCT
finefocus-541	119	44	.	.	PUNCT
finefocus-541	120	1	we	we	PRON
finefocus-541	120	2	now	now	ADV
finefocus-541	120	3	expand	expand	VERB
finefocus-541	120	4	upon	upon	SCONJ
finefocus-541	120	5	that	that	DET
finefocus-541	120	6	hypothesis	hypothesis	NOUN
finefocus-541	120	7	,	,	PUNCT
finefocus-541	120	8	suggesting	suggest	VERB
finefocus-541	120	9	that	that	SCONJ
finefocus-541	120	10	the	the	DET
finefocus-541	120	11	dynamic	dynamic	ADJ
finefocus-541	120	12	movement	movement	NOUN
finefocus-541	120	13	of	of	ADP
finefocus-541	120	14	extracellular	extracellular	ADJ
finefocus-541	120	15	bacteria	bacteria	NOUN
finefocus-541	120	16	to	to	ADP
finefocus-541	120	17	the	the	DET
finefocus-541	120	18	intracellular	intracellular	ADJ
finefocus-541	120	19	compartment	compartment	NOUN
finefocus-541	120	20	may	may	AUX
finefocus-541	120	21	protect	protect	VERB
finefocus-541	120	22	them	they	PRON
finefocus-541	120	23	from	from	ADP
finefocus-541	120	24	the	the	DET
finefocus-541	120	25	antibiotic	antibiotic	NOUN
finefocus-541	120	26	.	.	PUNCT
finefocus-541	121	1	this	this	DET
finefocus-541	121	2	protected	protect	VERB
finefocus-541	121	3	movement	movement	NOUN
finefocus-541	121	4	between	between	ADP
finefocus-541	121	5	compartments	compartment	NOUN
finefocus-541	121	6	may	may	AUX
finefocus-541	121	7	explain	explain	VERB
finefocus-541	121	8	why	why	SCONJ
finefocus-541	121	9	bacteria	bacteria	NOUN
finefocus-541	121	10	are	be	AUX
finefocus-541	121	11	still	still	ADV
finefocus-541	121	12	present	present	ADJ
finefocus-541	121	13	in	in	ADP
finefocus-541	121	14	low	low	ADJ
finefocus-541	121	15	numbers	number	NOUN
finefocus-541	121	16	in	in	ADP
finefocus-541	121	17	the	the	DET
finefocus-541	121	18	extracellular	extracellular	ADJ
finefocus-541	121	19	niche	niche	NOUN
finefocus-541	121	20	of	of	ADP
finefocus-541	121	21	the	the	DET
finefocus-541	121	22	macrophage	macrophage	ADJ
finefocus-541	121	23	infection	infection	NOUN
finefocus-541	121	24	model	model	NOUN
finefocus-541	121	25	after	after	ADP
finefocus-541	121	26	18	18	NUM
finefocus-541	121	27	hours	hour	NOUN
finefocus-541	121	28	of	of	ADP
finefocus-541	121	29	treatment	treatment	NOUN
finefocus-541	121	30	,	,	PUNCT
finefocus-541	121	31	and	and	CCONJ
finefocus-541	121	32	yet	yet	ADV
finefocus-541	121	33	are	be	AUX
finefocus-541	121	34	still	still	ADV
finefocus-541	121	35	sensitive	sensitive	ADJ
finefocus-541	121	36	to	to	ADP
finefocus-541	121	37	the	the	DET
finefocus-541	121	38	antibiotic	antibiotic	NOUN
finefocus-541	121	39	.	.	PUNCT
finefocus-541	122	1	perhaps	perhaps	ADV
finefocus-541	122	2	it	it	PRON
finefocus-541	122	3	is	be	AUX
finefocus-541	122	4	the	the	DET
finefocus-541	122	5	rapid	rapid	ADJ
finefocus-541	122	6	movement	movement	NOUN
finefocus-541	122	7	between	between	ADP
finefocus-541	122	8	extracellular	extracellular	ADJ
finefocus-541	122	9	and	and	CCONJ
finefocus-541	122	10	intracellular	intracellular	ADJ
finefocus-541	122	11	compartments	compartment	NOUN
finefocus-541	122	12	that	that	PRON
finefocus-541	122	13	accounts	account	VERB
finefocus-541	122	14	for	for	ADP
finefocus-541	122	15	their	their	PRON
finefocus-541	122	16	protection	protection	NOUN
finefocus-541	122	17	from	from	ADP
finefocus-541	122	18	the	the	DET
finefocus-541	122	19	antibiotic	antibiotic	NOUN
finefocus-541	122	20	.	.	PUNCT
finefocus-541	123	1	future	future	ADJ
finefocus-541	123	2	studies	study	NOUN
finefocus-541	123	3	will	will	AUX
finefocus-541	123	4	attempt	attempt	VERB
finefocus-541	123	5	to	to	PART
finefocus-541	123	6	tease	tease	VERB
finefocus-541	123	7	out	out	ADP
finefocus-541	123	8	these	these	DET
finefocus-541	123	9	nuances	nuance	NOUN
finefocus-541	123	10	of	of	ADP
finefocus-541	123	11	the	the	DET
finefocus-541	123	12	macrophage	macrophage	ADJ
finefocus-541	123	13	infection	infection	NOUN
finefocus-541	123	14	model	model	NOUN
finefocus-541	123	15	through	through	ADP
finefocus-541	123	16	visualization	visualization	NOUN
finefocus-541	123	17	of	of	ADP
finefocus-541	123	18	real	real	ADJ
finefocus-541	123	19	-	-	PUNCT
finefocus-541	123	20	time	time	NOUN
finefocus-541	123	21	infections	infection	NOUN
finefocus-541	123	22	.	.	PUNCT
finefocus-541	124	1	the	the	DET
finefocus-541	124	2	interactions	interaction	NOUN
finefocus-541	124	3	between	between	ADP
finefocus-541	124	4	bacteria	bacteria	NOUN
finefocus-541	124	5	in	in	ADP
finefocus-541	124	6	the	the	DET
finefocus-541	124	7	intracellular	intracellular	NOUN
finefocus-541	124	8	and	and	CCONJ
finefocus-541	124	9	extracellular	extracellular	ADJ
finefocus-541	124	10	compartments	compartment	NOUN
finefocus-541	124	11	could	could	AUX
finefocus-541	124	12	also	also	ADV
finefocus-541	124	13	be	be	AUX
finefocus-541	124	14	studied	study	VERB
finefocus-541	124	15	through	through	ADP
finefocus-541	124	16	repeated	repeat	VERB
finefocus-541	124	17	saline	saline	ADJ
finefocus-541	124	18	washes	wash	NOUN
finefocus-541	124	19	of	of	ADP
finefocus-541	124	20	the	the	DET
finefocus-541	124	21	extracellular	extracellular	ADJ
finefocus-541	124	22	compartment	compartment	NOUN
finefocus-541	124	23	throughout	throughout	ADP
finefocus-541	124	24	the	the	DET
finefocus-541	124	25	18	18	NUM
finefocus-541	124	26	hour	hour	NOUN
finefocus-541	124	27	infection	infection	NOUN
finefocus-541	124	28	.	.	PUNCT
finefocus-541	125	1	if	if	SCONJ
finefocus-541	125	2	there	there	PRON
finefocus-541	125	3	is	be	VERB
finefocus-541	125	4	a	a	DET
finefocus-541	125	5	dynamic	dynamic	ADJ
finefocus-541	125	6	movement	movement	NOUN
finefocus-541	125	7	of	of	ADP
finefocus-541	125	8	bacteria	bacteria	NOUN
finefocus-541	125	9	between	between	ADP
finefocus-541	125	10	compartments	compartment	NOUN
finefocus-541	125	11	,	,	PUNCT
finefocus-541	125	12	and	and	CCONJ
finefocus-541	125	13	if	if	SCONJ
finefocus-541	125	14	the	the	DET
finefocus-541	125	15	bacteria	bacteria	NOUN
finefocus-541	125	16	are	be	AUX
finefocus-541	125	17	not	not	PART
finefocus-541	125	18	able	able	ADJ
finefocus-541	125	19	to	to	PART
finefocus-541	125	20	re	re	VERB
finefocus-541	125	21	-	-	VERB
finefocus-541	125	22	infect	infect	VERB
finefocus-541	125	23	the	the	DET
finefocus-541	125	24	macrophages	macrophage	NOUN
finefocus-541	125	25	once	once	ADV
finefocus-541	125	26	released	release	VERB
finefocus-541	125	27	to	to	ADP
finefocus-541	125	28	the	the	DET
finefocus-541	125	29	extracellular	extracellular	ADJ
finefocus-541	125	30	compartment	compartment	NOUN
finefocus-541	125	31	,	,	PUNCT
finefocus-541	125	32	we	we	PRON
finefocus-541	125	33	would	would	AUX
finefocus-541	125	34	expect	expect	VERB
finefocus-541	125	35	the	the	DET
finefocus-541	125	36	intracellular	intracellular	ADJ
finefocus-541	125	37	numbers	number	NOUN
finefocus-541	125	38	to	to	PART
finefocus-541	125	39	fall	fall	VERB
finefocus-541	125	40	more	more	ADV
finefocus-541	125	41	quickly	quickly	ADV
finefocus-541	125	42	over	over	ADP
finefocus-541	125	43	time	time	NOUN
finefocus-541	125	44	upon	upon	SCONJ
finefocus-541	125	45	treatment	treatment	NOUN
finefocus-541	125	46	with	with	ADP
finefocus-541	125	47	the	the	DET
finefocus-541	125	48	synergistic	synergistic	ADJ
finefocus-541	125	49	combination	combination	NOUN
finefocus-541	125	50	of	of	ADP
finefocus-541	125	51	ifn	ifn	PROPN
finefocus-541	125	52	-	-	PUNCT
finefocus-541	125	53	γ	γ	NOUN
finefocus-541	125	54	and	and	CCONJ
finefocus-541	125	55	ceftazidime	ceftazidime	NOUN
finefocus-541	125	56	.	.	PUNCT
finefocus-541	126	1	even	even	ADV
finefocus-541	126	2	if	if	SCONJ
finefocus-541	126	3	the	the	DET
finefocus-541	126	4	bacteria	bacteria	NOUN
finefocus-541	126	5	are	be	AUX
finefocus-541	126	6	neither	neither	CCONJ
finefocus-541	126	7	resistant	resistant	ADJ
finefocus-541	126	8	nor	nor	CCONJ
finefocus-541	126	9	persister	persister	NOUN
finefocus-541	126	10	cells	cell	NOUN
finefocus-541	126	11	,	,	PUNCT
finefocus-541	126	12	there	there	PRON
finefocus-541	126	13	might	might	AUX
finefocus-541	126	14	be	be	AUX
finefocus-541	126	15	some	some	DET
finefocus-541	126	16	difference	difference	NOUN
finefocus-541	126	17	in	in	ADP
finefocus-541	126	18	susceptibility	susceptibility	NOUN
finefocus-541	126	19	of	of	ADP
finefocus-541	126	20	the	the	DET
finefocus-541	126	21	extracellular	extracellular	ADJ
finefocus-541	126	22	bacteria	bacteria	NOUN
finefocus-541	126	23	that	that	PRON
finefocus-541	126	24	remain	remain	VERB
finefocus-541	126	25	at	at	ADP
finefocus-541	126	26	the	the	DET
finefocus-541	126	27	end	end	NOUN
finefocus-541	126	28	of	of	ADP
finefocus-541	126	29	the	the	DET
finefocus-541	126	30	macrophage	macrophage	ADJ
finefocus-541	126	31	infection	infection	NOUN
finefocus-541	126	32	compared	compare	VERB
finefocus-541	126	33	to	to	ADP
finefocus-541	126	34	bacteria	bacteria	NOUN
finefocus-541	126	35	from	from	ADP
finefocus-541	126	36	untreated	untreated	ADJ
finefocus-541	126	37	wells	well	NOUN
finefocus-541	126	38	of	of	ADP
finefocus-541	126	39	the	the	DET
finefocus-541	126	40	macrophage	macrophage	ADJ
finefocus-541	126	41	infection	infection	NOUN
finefocus-541	126	42	.	.	PUNCT
finefocus-541	127	1	future	future	ADJ
finefocus-541	127	2	experiments	experiment	NOUN
finefocus-541	127	3	to	to	PART
finefocus-541	127	4	compare	compare	VERB
finefocus-541	127	5	the	the	DET
finefocus-541	127	6	rate	rate	NOUN
finefocus-541	127	7	of	of	ADP
finefocus-541	127	8	killing	killing	NOUN
finefocus-541	127	9	of	of	ADP
finefocus-541	127	10	the	the	DET
finefocus-541	127	11	extracellular	extracellular	ADJ
finefocus-541	127	12	bacteria	bacteria	NOUN
finefocus-541	127	13	that	that	PRON
finefocus-541	127	14	came	come	VERB
finefocus-541	127	15	from	from	ADP
finefocus-541	127	16	antibiotic	antibiotic	NOUN
finefocus-541	127	17	-	-	PUNCT
finefocus-541	127	18	treated	treat	VERB
finefocus-541	127	19	macrophages	macrophage	NOUN
finefocus-541	127	20	to	to	ADP
finefocus-541	127	21	those	those	PRON
finefocus-541	127	22	that	that	PRON
finefocus-541	127	23	came	come	VERB
finefocus-541	127	24	from	from	ADP
finefocus-541	127	25	untreated	untreated	ADJ
finefocus-541	127	26	macrophages	macrophage	NOUN
finefocus-541	127	27	,	,	PUNCT
finefocus-541	127	28	and	and	CCONJ
finefocus-541	127	29	even	even	ADV
finefocus-541	127	30	to	to	ADP
finefocus-541	127	31	bacteria	bacteria	NOUN
finefocus-541	127	32	never	never	ADV
finefocus-541	127	33	exposed	expose	VERB
finefocus-541	127	34	to	to	ADP
finefocus-541	127	35	macrophages	macrophage	NOUN
finefocus-541	127	36	.	.	PUNCT
finefocus-541	128	1	these	these	DET
finefocus-541	128	2	experiments	experiment	NOUN
finefocus-541	128	3	could	could	AUX
finefocus-541	128	4	determine	determine	VERB
finefocus-541	128	5	if	if	SCONJ
finefocus-541	128	6	interactions	interaction	NOUN
finefocus-541	128	7	with	with	ADP
finefocus-541	128	8	the	the	DET
finefocus-541	128	9	macrophages	macrophage	NOUN
finefocus-541	128	10	affords	afford	VERB
finefocus-541	128	11	the	the	DET
finefocus-541	128	12	bacteria	bacteria	NOUN
finefocus-541	128	13	any	any	DET
finefocus-541	128	14	amount	amount	NOUN
finefocus-541	128	15	of	of	ADP
finefocus-541	128	16	tolerance	tolerance	NOUN
finefocus-541	128	17	to	to	ADP
finefocus-541	128	18	the	the	DET
finefocus-541	128	19	antibiotic	antibiotic	NOUN
finefocus-541	128	20	.	.	PUNCT
finefocus-541	129	1	lower	low	ADJ
finefocus-541	129	2	doses	dose	NOUN
finefocus-541	129	3	of	of	ADP
finefocus-541	129	4	antibiotic	antibiotic	NOUN
finefocus-541	129	5	could	could	AUX
finefocus-541	129	6	also	also	ADV
finefocus-541	129	7	be	be	AUX
finefocus-541	129	8	used	use	VERB
finefocus-541	129	9	against	against	ADP
finefocus-541	129	10	these	these	DET
finefocus-541	129	11	groups	group	NOUN
finefocus-541	129	12	to	to	PART
finefocus-541	129	13	compare	compare	VERB
finefocus-541	129	14	killing	kill	VERB
finefocus-541	129	15	curves	curve	NOUN
finefocus-541	129	16	.	.	PUNCT
finefocus-541	130	1	in	in	ADP
finefocus-541	130	2	conclusion	conclusion	NOUN
finefocus-541	130	3	,	,	PUNCT
finefocus-541	130	4	we	we	PRON
finefocus-541	130	5	have	have	AUX
finefocus-541	130	6	shown	show	VERB
finefocus-541	130	7	evidence	evidence	NOUN
finefocus-541	130	8	that	that	SCONJ
finefocus-541	130	9	the	the	DET
finefocus-541	130	10	b.	b.	PROPN
finefocus-541	130	11	thailandensis	thailandensis	PROPN
finefocus-541	130	12	cells	cell	NOUN
finefocus-541	130	13	that	that	PRON
finefocus-541	130	14	survive	survive	VERB
finefocus-541	130	15	ceftazidime	ceftazidime	NOUN
finefocus-541	130	16	treatment	treatment	NOUN
finefocus-541	130	17	for	for	ADP
finefocus-541	130	18	18	18	NUM
finefocus-541	130	19	-	-	SYM
finefocus-541	130	20	24	24	NUM
finefocus-541	130	21	hours	hour	NOUN
finefocus-541	130	22	in	in	ADP
finefocus-541	130	23	the	the	DET
finefocus-541	130	24	macrophage	macrophage	ADJ
finefocus-541	130	25	infection	infection	NOUN
finefocus-541	130	26	model	model	NOUN
finefocus-541	130	27	are	be	AUX
finefocus-541	130	28	still	still	ADV
finefocus-541	130	29	sensitive	sensitive	ADJ
finefocus-541	130	30	to	to	ADP
finefocus-541	130	31	high	high	ADJ
finefocus-541	130	32	and	and	CCONJ
finefocus-541	130	33	low	low	ADJ
finefocus-541	130	34	concentrations	concentration	NOUN
finefocus-541	130	35	of	of	ADP
finefocus-541	130	36	ceftazidime	ceftazidime	NOUN
finefocus-541	130	37	,	,	PUNCT
finefocus-541	130	38	and	and	CCONJ
finefocus-541	130	39	they	they	PRON
finefocus-541	130	40	are	be	AUX
finefocus-541	130	41	not	not	PART
finefocus-541	130	42	classically	classically	ADV
finefocus-541	130	43	resistant	resistant	ADJ
finefocus-541	130	44	nor	nor	CCONJ
finefocus-541	130	45	are	be	AUX
finefocus-541	130	46	they	they	PRON
finefocus-541	130	47	persister	persister	ADJ
finefocus-541	130	48	cells	cell	NOUN
finefocus-541	130	49	.	.	PUNCT
finefocus-541	131	1	we	we	PRON
finefocus-541	131	2	hypothesize	hypothesize	VERB
finefocus-541	131	3	that	that	SCONJ
finefocus-541	131	4	the	the	DET
finefocus-541	131	5	ability	ability	NOUN
finefocus-541	131	6	of	of	ADP
finefocus-541	131	7	the	the	DET
finefocus-541	131	8	bacteria	bacteria	NOUN
finefocus-541	131	9	to	to	PART
finefocus-541	131	10	move	move	VERB
finefocus-541	131	11	between	between	ADP
finefocus-541	131	12	intracellular	intracellular	ADJ
finefocus-541	131	13	and	and	CCONJ
finefocus-541	131	14	extracellular	extracellular	ADJ
finefocus-541	131	15	compartments	compartment	NOUN
finefocus-541	131	16	during	during	ADP
finefocus-541	131	17	the	the	DET
finefocus-541	131	18	macrophage	macrophage	ADJ
finefocus-541	131	19	infection	infection	NOUN
finefocus-541	131	20	likely	likely	ADV
finefocus-541	131	21	accounts	account	VERB
finefocus-541	131	22	for	for	ADP
finefocus-541	131	23	their	their	PRON
finefocus-541	131	24	ability	ability	NOUN
finefocus-541	131	25	to	to	PART
finefocus-541	131	26	survive	survive	VERB
finefocus-541	131	27	long	long	ADJ
finefocus-541	131	28	periods	period	NOUN
finefocus-541	131	29	of	of	ADP
finefocus-541	131	30	time	time	NOUN
finefocus-541	131	31	in	in	ADP
finefocus-541	131	32	the	the	DET
finefocus-541	131	33	presence	presence	NOUN
finefocus-541	131	34	of	of	ADP
finefocus-541	131	35	bactericidal	bactericidal	ADJ
finefocus-541	131	36	concentrations	concentration	NOUN
finefocus-541	131	37	of	of	ADP
finefocus-541	131	38	ceftazidime	ceftazidime	NOUN
finefocus-541	131	39	.	.	PUNCT
finefocus-541	132	1	future	future	ADJ
finefocus-541	132	2	studies	study	NOUN
finefocus-541	132	3	will	will	AUX
finefocus-541	132	4	continue	continue	VERB
finefocus-541	132	5	to	to	PART
finefocus-541	132	6	investigate	investigate	VERB
finefocus-541	132	7	various	various	ADJ
finefocus-541	132	8	host	host	NOUN
finefocus-541	132	9	-	-	PUNCT
finefocus-541	132	10	pathogen	pathogen	NOUN
finefocus-541	132	11	interactions	interaction	NOUN
finefocus-541	132	12	of	of	ADP
finefocus-541	132	13	this	this	DET
finefocus-541	132	14	macrophage	macrophage	ADJ
finefocus-541	132	15	infection	infection	NOUN
finefocus-541	132	16	model	model	NOUN
finefocus-541	132	17	.	.	PUNCT
finefocus-541	133	1	127pathogens	127pathogens	NUM
finefocus-541	133	2	&	&	CCONJ
finefocus-541	133	3	antimicrobial	antimicrobial	ADJ
finefocus-541	133	4	factors	factor	NOUN
finefocus-541	133	5	•	•	NUM
finefocus-541	133	6	acknowledgements	acknowledgement	NOUN
finefocus-541	133	7	all	all	DET
finefocus-541	133	8	research	research	NOUN
finefocus-541	133	9	was	be	AUX
finefocus-541	133	10	conducted	conduct	VERB
finefocus-541	133	11	at	at	ADP
finefocus-541	133	12	moravian	moravian	ADJ
finefocus-541	133	13	college	college	NOUN
finefocus-541	133	14	in	in	ADP
finefocus-541	133	15	biosafety	biosafety	NOUN
finefocus-541	133	16	level-2	level-2	PROPN
finefocus-541	133	17	facilities	facility	NOUN
finefocus-541	133	18	in	in	ADP
finefocus-541	133	19	compliance	compliance	NOUN
finefocus-541	133	20	with	with	ADP
finefocus-541	133	21	federal	federal	ADJ
finefocus-541	133	22	and	and	CCONJ
finefocus-541	133	23	institutional	institutional	ADJ
finefocus-541	133	24	regulations	regulation	NOUN
finefocus-541	133	25	for	for	ADP
finefocus-541	133	26	handling	handle	VERB
finefocus-541	133	27	infectious	infectious	ADJ
finefocus-541	133	28	agents	agent	NOUN
finefocus-541	133	29	.	.	PUNCT
finefocus-541	134	1	funding	funding	NOUN
finefocus-541	134	2	was	be	AUX
finefocus-541	134	3	provided	provide	VERB
finefocus-541	134	4	by	by	ADP
finefocus-541	134	5	the	the	DET
finefocus-541	134	6	beta	beta	PROPN
finefocus-541	134	7	beta	beta	PROPN
finefocus-541	134	8	beta	beta	NOUN
finefocus-541	134	9	research	research	NOUN
finefocus-541	134	10	scholarship	scholarship	NOUN
finefocus-541	134	11	foundation	foundation	NOUN
finefocus-541	134	12	fund	fund	NOUN
finefocus-541	134	13	as	as	ADV
finefocus-541	134	14	well	well	ADV
finefocus-541	134	15	as	as	ADP
finefocus-541	134	16	the	the	DET
finefocus-541	134	17	department	department	NOUN
finefocus-541	134	18	of	of	ADP
finefocus-541	134	19	biological	biological	ADJ
finefocus-541	134	20	sciences	science	NOUN
finefocus-541	134	21	at	at	ADP
finefocus-541	134	22	moravian	moravian	ADJ
finefocus-541	134	23	college	college	NOUN
finefocus-541	134	24	.	.	PUNCT
finefocus-541	135	1	128•	128•	PROPN
finefocus-541	135	2	fine	fine	ADJ
finefocus-541	135	3	focus	focus	NOUN
finefocus-541	135	4	,	,	PUNCT
finefocus-541	135	5	vol	vol	NOUN
finefocus-541	135	6	.	.	PUNCT
finefocus-541	135	7	4(1	4(1	NOUN
finefocus-541	135	8	)	)	PUNCT
finefocus-541	135	9	references	reference	NOUN
finefocus-541	135	10	1	1	NUM
finefocus-541	135	11	.	.	PUNCT
finefocus-541	136	1	allwood	allwood	PROPN
finefocus-541	136	2	,	,	PUNCT
finefocus-541	136	3	e.	e.	PROPN
finefocus-541	136	4	m.	m.	PROPN
finefocus-541	136	5	,	,	PUNCT
finefocus-541	136	6	devenish	devenish	PROPN
finefocus-541	136	7	,	,	PUNCT
finefocus-541	136	8	r.	r.	PROPN
finefocus-541	136	9	j.	j.	PROPN
finefocus-541	136	10	,	,	PUNCT
finefocus-541	136	11	prescott	prescott	PROPN
finefocus-541	136	12	,	,	PUNCT
finefocus-541	136	13	m.	m.	NOUN
finefocus-541	136	14	,	,	PUNCT
finefocus-541	136	15	adler	adler	PROPN
finefocus-541	136	16	,	,	PUNCT
finefocus-541	136	17	b.	b.	PROPN
finefocus-541	136	18	,	,	PUNCT
finefocus-541	136	19	&	&	CCONJ
finefocus-541	136	20	boyce	boyce	PROPN
finefocus-541	136	21	,	,	PUNCT
finefocus-541	136	22	j.	j.	PROPN
finefocus-541	136	23	d.	d.	PROPN
finefocus-541	136	24	(	(	PUNCT
finefocus-541	136	25	2011	2011	NUM
finefocus-541	136	26	)	)	PUNCT
finefocus-541	136	27	.	.	PUNCT
finefocus-541	137	1	strategies	strategy	NOUN
finefocus-541	137	2	for	for	ADP
finefocus-541	137	3	intracellular	intracellular	ADJ
finefocus-541	137	4	survival	survival	NOUN
finefocus-541	137	5	of	of	ADP
finefocus-541	137	6	burkholderia	burkholderia	PROPN
finefocus-541	137	7	pseudomallei	pseudomallei	NOUN
finefocus-541	137	8	.	.	PUNCT
finefocus-541	138	1	front	front	ADJ
finefocus-541	138	2	microbiol	microbiol	PROPN
finefocus-541	138	3	,	,	PUNCT
finefocus-541	138	4	2	2	NUM
finefocus-541	138	5	,	,	PUNCT
finefocus-541	138	6	170	170	NUM
finefocus-541	138	7	2	2	NUM
finefocus-541	138	8	.	.	PUNCT
finefocus-541	138	9	butt	butt	PROPN
finefocus-541	138	10	,	,	PUNCT
finefocus-541	138	11	a.	a.	NOUN
finefocus-541	138	12	,	,	PUNCT
finefocus-541	138	13	higman	higman	NOUN
finefocus-541	138	14	,	,	PUNCT
finefocus-541	138	15	v.	v.	PROPN
finefocus-541	138	16	a.	a.	PROPN
finefocus-541	138	17	,	,	PUNCT
finefocus-541	138	18	williams	williams	PROPN
finefocus-541	138	19	,	,	PUNCT
finefocus-541	138	20	c.	c.	PROPN
finefocus-541	138	21	,	,	PUNCT
finefocus-541	138	22	crump	crump	NOUN
finefocus-541	138	23	,	,	PUNCT
finefocus-541	138	24	m.	m.	NOUN
finefocus-541	138	25	p.	p.	PROPN
finefocus-541	138	26	,	,	PUNCT
finefocus-541	138	27	hemsley	hemsley	PROPN
finefocus-541	138	28	,	,	PUNCT
finefocus-541	138	29	c.	c.	PROPN
finefocus-541	138	30	m.	m.	PROPN
finefocus-541	138	31	,	,	PUNCT
finefocus-541	138	32	harmer	harmer	PROPN
finefocus-541	138	33	,	,	PUNCT
finefocus-541	138	34	n.	n.	PROPN
finefocus-541	138	35	,	,	PUNCT
finefocus-541	138	36	&	&	CCONJ
finefocus-541	138	37	titball	titball	PROPN
finefocus-541	138	38	,	,	PUNCT
finefocus-541	138	39	r.	r.	PROPN
finefocus-541	138	40	w.	w.	PROPN
finefocus-541	138	41	(	(	PUNCT
finefocus-541	138	42	2014	2014	NUM
finefocus-541	138	43	)	)	PUNCT
finefocus-541	138	44	.	.	PUNCT
finefocus-541	139	1	the	the	DET
finefocus-541	139	2	hica	hica	PROPN
finefocus-541	139	3	toxin	toxin	NOUN
finefocus-541	139	4	from	from	ADP
finefocus-541	139	5	burkholderia	burkholderia	NOUN
finefocus-541	139	6	pseudomallei	pseudomallei	NOUN
finefocus-541	139	7	has	have	VERB
finefocus-541	139	8	a	a	DET
finefocus-541	139	9	role	role	NOUN
finefocus-541	139	10	in	in	ADP
finefocus-541	139	11	persister	persister	ADJ
finefocus-541	139	12	cell	cell	NOUN
finefocus-541	139	13	formation	formation	NOUN
finefocus-541	139	14	.	.	PUNCT
finefocus-541	140	1	biochem	biochem	PROPN
finefocus-541	140	2	j	j	PROPN
finefocus-541	140	3	,	,	PUNCT
finefocus-541	140	4	459(2	459(2	NUM
finefocus-541	140	5	)	)	PUNCT
finefocus-541	140	6	,	,	PUNCT
finefocus-541	140	7	333	333	NUM
finefocus-541	140	8	-	-	SYM
finefocus-541	140	9	344	344	NUM
finefocus-541	140	10	.	.	PUNCT
finefocus-541	141	1	3	3	X
finefocus-541	141	2	.	.	X
finefocus-541	141	3	dawson	dawson	PROPN
finefocus-541	141	4	,	,	PUNCT
finefocus-541	141	5	c.	c.	PROPN
finefocus-541	141	6	c.	c.	PROPN
finefocus-541	141	7	,	,	PUNCT
finefocus-541	141	8	intapa	intapa	NOUN
finefocus-541	141	9	,	,	PUNCT
finefocus-541	141	10	c.	c.	PROPN
finefocus-541	141	11	,	,	PUNCT
finefocus-541	141	12	&	&	CCONJ
finefocus-541	141	13	jabrarizk	jabrarizk	PROPN
finefocus-541	141	14	,	,	PUNCT
finefocus-541	141	15	m.	m.	NOUN
finefocus-541	141	16	a.	a.	NOUN
finefocus-541	141	17	(	(	PUNCT
finefocus-541	141	18	2011	2011	NUM
finefocus-541	141	19	)	)	PUNCT
finefocus-541	141	20	.	.	PUNCT
finefocus-541	142	1	“	"	PUNCT
finefocus-541	142	2	persisters	persister	NOUN
finefocus-541	142	3	”	"	PUNCT
finefocus-541	142	4	:	:	PUNCT
finefocus-541	142	5	survival	survival	NOUN
finefocus-541	142	6	at	at	ADP
finefocus-541	142	7	the	the	DET
finefocus-541	142	8	cellular	cellular	ADJ
finefocus-541	142	9	level	level	NOUN
finefocus-541	142	10	.	.	PUNCT
finefocus-541	143	1	plos	plos	PROPN
finefocus-541	143	2	pathog	pathog	PROPN
finefocus-541	143	3	,	,	PUNCT
finefocus-541	143	4	7(7	7(7	NUM
finefocus-541	143	5	)	)	PUNCT
finefocus-541	143	6	,	,	PUNCT
finefocus-541	143	7	e1002121	e1002121	PROPN
finefocus-541	143	8	.	.	PROPN
finefocus-541	144	1	4	4	NUM
finefocus-541	144	2	.	.	X
finefocus-541	144	3	fauvart	fauvart	NOUN
finefocus-541	144	4	,	,	PUNCT
finefocus-541	144	5	m.	m.	NOUN
finefocus-541	144	6	,	,	PUNCT
finefocus-541	144	7	de	de	X
finefocus-541	144	8	groote	groote	NOUN
finefocus-541	144	9	,	,	PUNCT
finefocus-541	144	10	v.	v.	ADP
finefocus-541	144	11	n.	n.	NOUN
finefocus-541	144	12	,	,	PUNCT
finefocus-541	144	13	&	&	CCONJ
finefocus-541	144	14	michiels	michiel	NOUN
finefocus-541	144	15	,	,	PUNCT
finefocus-541	144	16	j.	j.	PROPN
finefocus-541	144	17	(	(	PUNCT
finefocus-541	144	18	2011	2011	NUM
finefocus-541	144	19	)	)	PUNCT
finefocus-541	144	20	.	.	PUNCT
finefocus-541	145	1	role	role	NOUN
finefocus-541	145	2	of	of	ADP
finefocus-541	145	3	persister	persister	NOUN
finefocus-541	145	4	cells	cell	NOUN
finefocus-541	145	5	in	in	ADP
finefocus-541	145	6	chronic	chronic	ADJ
finefocus-541	145	7	infections	infection	NOUN
finefocus-541	145	8	:	:	PUNCT
finefocus-541	145	9	clinical	clinical	ADJ
finefocus-541	145	10	relevance	relevance	NOUN
finefocus-541	145	11	and	and	CCONJ
finefocus-541	145	12	perspectives	perspective	NOUN
finefocus-541	145	13	on	on	ADP
finefocus-541	145	14	anti	anti	ADJ
finefocus-541	145	15	-	-	ADJ
finefocus-541	145	16	persister	persister	ADJ
finefocus-541	145	17	therapies	therapy	NOUN
finefocus-541	145	18	.	.	PUNCT
finefocus-541	146	1	j	j	PROPN
finefocus-541	146	2	med	med	PROPN
finefocus-541	146	3	microbiol	microbiol	PROPN
finefocus-541	146	4	,	,	PUNCT
finefocus-541	146	5	60(pt	60(pt	PROPN
finefocus-541	146	6	6	6	NUM
finefocus-541	146	7	)	)	PUNCT
finefocus-541	146	8	,	,	PUNCT
finefocus-541	146	9	699	699	NUM
finefocus-541	146	10	-	-	SYM
finefocus-541	146	11	709	709	NUM
finefocus-541	146	12	.	.	PUNCT
finefocus-541	147	1	5	5	NUM
finefocus-541	147	2	.	.	X
finefocus-541	148	1	jayaraman	jayaraman	NOUN
finefocus-541	148	2	,	,	PUNCT
finefocus-541	148	3	r.	r.	PROPN
finefocus-541	148	4	(	(	PUNCT
finefocus-541	148	5	2008	2008	NUM
finefocus-541	148	6	)	)	PUNCT
finefocus-541	148	7	.	.	PUNCT
finefocus-541	149	1	bacterial	bacterial	ADJ
finefocus-541	149	2	persistence	persistence	NOUN
finefocus-541	149	3	:	:	PUNCT
finefocus-541	149	4	some	some	DET
finefocus-541	149	5	new	new	ADJ
finefocus-541	149	6	insights	insight	NOUN
finefocus-541	149	7	into	into	ADP
finefocus-541	149	8	an	an	DET
finefocus-541	149	9	old	old	ADJ
finefocus-541	149	10	phenomenon	phenomenon	NOUN
finefocus-541	149	11	.	.	PUNCT
finefocus-541	150	1	j	j	PROPN
finefocus-541	150	2	biosci	biosci	PROPN
finefocus-541	150	3	,	,	PUNCT
finefocus-541	150	4	33(5	33(5	NUM
finefocus-541	150	5	)	)	PUNCT
finefocus-541	150	6	,	,	PUNCT
finefocus-541	150	7	795	795	NUM
finefocus-541	150	8	-	-	SYM
finefocus-541	150	9	805	805	NUM
finefocus-541	150	10	.	.	NOUN
finefocus-541	151	1	6	6	NUM
finefocus-541	151	2	.	.	X
finefocus-541	151	3	keren	keren	PROPN
finefocus-541	151	4	,	,	PUNCT
finefocus-541	151	5	i.	i.	PROPN
finefocus-541	151	6	,	,	PUNCT
finefocus-541	151	7	shah	shah	PROPN
finefocus-541	151	8	,	,	PUNCT
finefocus-541	151	9	d.	d.	PROPN
finefocus-541	151	10	,	,	PUNCT
finefocus-541	151	11	spoering	spoering	NOUN
finefocus-541	151	12	,	,	PUNCT
finefocus-541	151	13	a.	a.	NOUN
finefocus-541	151	14	,	,	PUNCT
finefocus-541	151	15	kaldalu	kaldalu	PROPN
finefocus-541	151	16	,	,	PUNCT
finefocus-541	151	17	n.	n.	NOUN
finefocus-541	151	18	,	,	PUNCT
finefocus-541	151	19	&	&	CCONJ
finefocus-541	151	20	lewis	lewis	PROPN
finefocus-541	151	21	,	,	PUNCT
finefocus-541	151	22	k.	k.	PROPN
finefocus-541	151	23	(	(	PUNCT
finefocus-541	151	24	2004	2004	NUM
finefocus-541	151	25	)	)	PUNCT
finefocus-541	151	26	.	.	PUNCT
finefocus-541	152	1	specialized	specialized	ADJ
finefocus-541	152	2	persister	persister	NOUN
finefocus-541	152	3	cells	cell	NOUN
finefocus-541	152	4	and	and	CCONJ
finefocus-541	152	5	the	the	DET
finefocus-541	152	6	mechanism	mechanism	NOUN
finefocus-541	152	7	of	of	ADP
finefocus-541	152	8	multidrug	multidrug	NOUN
finefocus-541	152	9	tolerance	tolerance	NOUN
finefocus-541	152	10	in	in	ADP
finefocus-541	152	11	escherichia	escherichia	NOUN
finefocus-541	152	12	coli	coli	NOUN
finefocus-541	152	13	.	.	PUNCT
finefocus-541	153	1	j	j	PROPN
finefocus-541	153	2	bacteriol	bacteriol	NOUN
finefocus-541	153	3	,	,	PUNCT
finefocus-541	153	4	186(24	186(24	NUM
finefocus-541	153	5	)	)	PUNCT
finefocus-541	153	6	,	,	PUNCT
finefocus-541	153	7	81728180	81728180	NUM
finefocus-541	153	8	.	.	PUNCT
finefocus-541	154	1	7	7	X
finefocus-541	154	2	.	.	X
finefocus-541	154	3	lewis	lewis	PROPN
finefocus-541	154	4	,	,	PUNCT
finefocus-541	154	5	k.	k.	PROPN
finefocus-541	154	6	(	(	PUNCT
finefocus-541	154	7	2005	2005	NUM
finefocus-541	154	8	)	)	PUNCT
finefocus-541	154	9	.	.	PUNCT
finefocus-541	155	1	persister	persister	NOUN
finefocus-541	155	2	cells	cell	NOUN
finefocus-541	155	3	and	and	CCONJ
finefocus-541	155	4	the	the	DET
finefocus-541	155	5	riddle	riddle	NOUN
finefocus-541	155	6	of	of	ADP
finefocus-541	155	7	biofilm	biofilm	NOUN
finefocus-541	155	8	survival	survival	NOUN
finefocus-541	155	9	.	.	PUNCT
finefocus-541	156	1	biochemistry	biochemistry	NOUN
finefocus-541	156	2	(	(	PUNCT
finefocus-541	156	3	mosc	mosc	PROPN
finefocus-541	156	4	)	)	PUNCT
finefocus-541	156	5	,	,	PUNCT
finefocus-541	156	6	70(2	70(2	PROPN
finefocus-541	156	7	)	)	PUNCT
finefocus-541	156	8	,	,	PUNCT
finefocus-541	156	9	267	267	NUM
finefocus-541	156	10	-	-	SYM
finefocus-541	156	11	274	274	NUM
finefocus-541	156	12	.	.	NOUN
finefocus-541	156	13	8	8	NUM
finefocus-541	156	14	.	.	X
finefocus-541	156	15	lewis	lewis	PROPN
finefocus-541	156	16	,	,	PUNCT
finefocus-541	156	17	k.	k.	PROPN
finefocus-541	156	18	(	(	PUNCT
finefocus-541	156	19	2007	2007	NUM
finefocus-541	156	20	)	)	PUNCT
finefocus-541	156	21	.	.	PUNCT
finefocus-541	157	1	persister	persister	NOUN
finefocus-541	157	2	cells	cell	NOUN
finefocus-541	157	3	,	,	PUNCT
finefocus-541	157	4	dormancy	dormancy	NOUN
finefocus-541	157	5	and	and	CCONJ
finefocus-541	157	6	infectious	infectious	ADJ
finefocus-541	157	7	disease	disease	NOUN
finefocus-541	157	8	.	.	PUNCT
finefocus-541	158	1	nat	nat	PROPN
finefocus-541	158	2	rev	rev	PROPN
finefocus-541	158	3	microbiol	microbiol	PROPN
finefocus-541	158	4	,	,	PUNCT
finefocus-541	158	5	5(1	5(1	NUM
finefocus-541	158	6	)	)	PUNCT
finefocus-541	158	7	,	,	PUNCT
finefocus-541	158	8	48	48	NUM
finefocus-541	158	9	-	-	SYM
finefocus-541	158	10	56	56	NUM
finefocus-541	158	11	.	.	NOUN
finefocus-541	158	12	9	9	NUM
finefocus-541	158	13	.	.	X
finefocus-541	158	14	maisonneuve	maisonneuve	PROPN
finefocus-541	158	15	,	,	PUNCT
finefocus-541	158	16	e.	e.	PROPN
finefocus-541	158	17	,	,	PUNCT
finefocus-541	158	18	&	&	CCONJ
finefocus-541	158	19	gerdes	gerdes	PROPN
finefocus-541	158	20	,	,	PUNCT
finefocus-541	158	21	k.	k.	PROPN
finefocus-541	158	22	(	(	PUNCT
finefocus-541	158	23	2014	2014	NUM
finefocus-541	158	24	)	)	PUNCT
finefocus-541	158	25	.	.	PUNCT
finefocus-541	159	1	molecular	molecular	ADJ
finefocus-541	159	2	mechanisms	mechanism	NOUN
finefocus-541	159	3	underlying	underlie	VERB
finefocus-541	159	4	bacterial	bacterial	ADJ
finefocus-541	159	5	persisters	persister	NOUN
finefocus-541	159	6	.	.	PUNCT
finefocus-541	160	1	cell	cell	NOUN
finefocus-541	160	2	,	,	PUNCT
finefocus-541	160	3	157(3	157(3	NUM
finefocus-541	160	4	)	)	PUNCT
finefocus-541	160	5	,	,	PUNCT
finefocus-541	160	6	539	539	NUM
finefocus-541	160	7	-	-	SYM
finefocus-541	160	8	548	548	NUM
finefocus-541	160	9	.	.	PUNCT
finefocus-541	161	1	10	10	NUM
finefocus-541	161	2	.	.	PUNCT
finefocus-541	162	1	mosovsky	mosovsky	PROPN
finefocus-541	162	2	,	,	PUNCT
finefocus-541	162	3	k.	k.	PROPN
finefocus-541	162	4	,	,	PUNCT
finefocus-541	162	5	silva	silva	PROPN
finefocus-541	162	6	,	,	PUNCT
finefocus-541	162	7	e.	e.	PROPN
finefocus-541	162	8	,	,	PUNCT
finefocus-541	162	9	troyer	troyer	PROPN
finefocus-541	162	10	,	,	PUNCT
finefocus-541	162	11	r.	r.	PROPN
finefocus-541	162	12	,	,	PUNCT
finefocus-541	162	13	propst	propst	PROPN
finefocus-541	162	14	-	-	PUNCT
finefocus-541	162	15	graham	graham	PROPN
finefocus-541	162	16	,	,	PUNCT
finefocus-541	162	17	k.	k.	PROPN
finefocus-541	162	18	,	,	PUNCT
finefocus-541	162	19	&	&	CCONJ
finefocus-541	162	20	dow	dow	PROPN
finefocus-541	162	21	,	,	PUNCT
finefocus-541	162	22	s.	s.	PROPN
finefocus-541	162	23	(	(	PUNCT
finefocus-541	162	24	2014	2014	NUM
finefocus-541	162	25	)	)	PUNCT
finefocus-541	162	26	.	.	PUNCT
finefocus-541	163	1	interaction	interaction	NOUN
finefocus-541	163	2	of	of	ADP
finefocus-541	163	3	interferon	interferon	ADJ
finefocus-541	163	4	gamma	gamma	NOUN
finefocus-541	163	5	-	-	PUNCT
finefocus-541	163	6	induced	induce	VERB
finefocus-541	163	7	reactive	reactive	ADJ
finefocus-541	163	8	oxygen	oxygen	NOUN
finefocus-541	163	9	species	specie	NOUN
finefocus-541	163	10	with	with	ADP
finefocus-541	163	11	ceftazidime	ceftazidime	NOUN
finefocus-541	163	12	leads	lead	VERB
finefocus-541	163	13	to	to	ADP
finefocus-541	163	14	synergistic	synergistic	ADJ
finefocus-541	163	15	killing	killing	NOUN
finefocus-541	163	16	of	of	ADP
finefocus-541	163	17	intracellular	intracellular	ADJ
finefocus-541	163	18	burkholderia	burkholderia	NOUN
finefocus-541	163	19	pseudomallei	pseudomallei	NOUN
finefocus-541	163	20	.	.	PUNCT
finefocus-541	164	1	antimicrob	antimicrob	PROPN
finefocus-541	164	2	agents	agents	PROPN
finefocus-541	164	3	chemother	chemother	PROPN
finefocus-541	164	4	,	,	PUNCT
finefocus-541	164	5	58(10	58(10	NUM
finefocus-541	164	6	)	)	PUNCT
finefocus-541	164	7	,	,	PUNCT
finefocus-541	164	8	5954	5954	NUM
finefocus-541	164	9	-	-	SYM
finefocus-541	164	10	5963	5963	NUM
finefocus-541	164	11	.	.	PUNCT
finefocus-541	165	1	11	11	NUM
finefocus-541	165	2	.	.	X
finefocus-541	166	1	nierman	nierman	PROPN
finefocus-541	166	2	,	,	PUNCT
finefocus-541	166	3	w.	w.	PROPN
finefocus-541	166	4	c.	c.	PROPN
finefocus-541	166	5	,	,	PUNCT
finefocus-541	166	6	yu	yu	PROPN
finefocus-541	166	7	,	,	PUNCT
finefocus-541	166	8	y.	y.	PROPN
finefocus-541	166	9	,	,	PUNCT
finefocus-541	166	10	&	&	CCONJ
finefocus-541	166	11	losada	losada	PROPN
finefocus-541	166	12	,	,	PUNCT
finefocus-541	166	13	l.	l.	PROPN
finefocus-541	166	14	(	(	PUNCT
finefocus-541	166	15	2015	2015	NUM
finefocus-541	166	16	)	)	PUNCT
finefocus-541	166	17	.	.	PUNCT
finefocus-541	167	1	the	the	DET
finefocus-541	167	2	in	in	ADV
finefocus-541	167	3	vitro	vitro	X
finefocus-541	167	4	antibiotic	antibiotic	ADJ
finefocus-541	167	5	tolerant	tolerant	ADJ
finefocus-541	167	6	persister	persister	NOUN
finefocus-541	167	7	population	population	NOUN
finefocus-541	167	8	in	in	ADP
finefocus-541	167	9	burkholderia	burkholderia	NOUN
finefocus-541	167	10	pseudomallei	pseudomallei	NOUN
finefocus-541	167	11	is	be	AUX
finefocus-541	167	12	altered	alter	VERB
finefocus-541	167	13	by	by	ADP
finefocus-541	167	14	environmental	environmental	ADJ
finefocus-541	167	15	factors	factor	NOUN
finefocus-541	167	16	.	.	PUNCT
finefocus-541	168	1	front	front	ADJ
finefocus-541	168	2	microbiol	microbiol	NOUN
finefocus-541	168	3	,	,	PUNCT
finefocus-541	168	4	6	6	NUM
finefocus-541	168	5	,	,	PUNCT
finefocus-541	168	6	1338	1338	NUM
finefocus-541	168	7	.	.	PUNCT
finefocus-541	169	1	12	12	NUM
finefocus-541	169	2	.	.	PUNCT
finefocus-541	169	3	propst	propst	PROPN
finefocus-541	169	4	,	,	PUNCT
finefocus-541	169	5	k.	k.	PROPN
finefocus-541	169	6	l.	l.	PROPN
finefocus-541	169	7	,	,	PUNCT
finefocus-541	169	8	troyer	troyer	PROPN
finefocus-541	169	9	,	,	PUNCT
finefocus-541	169	10	r.	r.	PROPN
finefocus-541	169	11	m.	m.	PROPN
finefocus-541	169	12	,	,	PUNCT
finefocus-541	169	13	kellihan	kellihan	PROPN
finefocus-541	169	14	,	,	PUNCT
finefocus-541	169	15	l.	l.	PROPN
finefocus-541	169	16	m.	m.	PROPN
finefocus-541	169	17	,	,	PUNCT
finefocus-541	169	18	schweizer	schweizer	PROPN
finefocus-541	169	19	,	,	PUNCT
finefocus-541	169	20	h.	h.	PROPN
finefocus-541	169	21	p.	p.	PROPN
finefocus-541	169	22	,	,	PUNCT
finefocus-541	169	23	&	&	CCONJ
finefocus-541	169	24	dow	dow	PROPN
finefocus-541	169	25	,	,	PUNCT
finefocus-541	169	26	s.	s.	PROPN
finefocus-541	169	27	w.	w.	PROPN
finefocus-541	169	28	(	(	PUNCT
finefocus-541	169	29	2010	2010	NUM
finefocus-541	169	30	)	)	PUNCT
finefocus-541	169	31	.	.	PUNCT
finefocus-541	170	1	immunotherapy	immunotherapy	NOUN
finefocus-541	170	2	markedly	markedly	ADV
finefocus-541	170	3	increases	increase	VERB
finefocus-541	170	4	the	the	DET
finefocus-541	170	5	effectiveness	effectiveness	NOUN
finefocus-541	170	6	of	of	ADP
finefocus-541	170	7	antimicrobial	antimicrobial	ADJ
finefocus-541	170	8	therapy	therapy	NOUN
finefocus-541	170	9	for	for	ADP
finefocus-541	170	10	treatment	treatment	NOUN
finefocus-541	170	11	of	of	ADP
finefocus-541	170	12	burkholderia	burkholderia	NOUN
finefocus-541	170	13	pseudomallei	pseudomallei	NOUN
finefocus-541	170	14	infection	infection	NOUN
finefocus-541	170	15	.	.	PUNCT
finefocus-541	171	1	129pathogens	129pathogens	PROPN
finefocus-541	171	2	&	&	CCONJ
finefocus-541	171	3	antimicrobial	antimicrobial	ADJ
finefocus-541	171	4	factors	factor	NOUN
finefocus-541	171	5	•	•	ADP
finefocus-541	171	6	antimicrob	antimicrob	PROPN
finefocus-541	171	7	agents	agent	NOUN
finefocus-541	171	8	chemother	chemother	PROPN
finefocus-541	171	9	,	,	PUNCT
finefocus-541	171	10	54(5	54(5	NUM
finefocus-541	171	11	)	)	PUNCT
finefocus-541	171	12	,	,	PUNCT
finefocus-541	171	13	17851792	17851792	NUM
finefocus-541	171	14	.	.	PUNCT
finefocus-541	172	1	13	13	NUM
finefocus-541	172	2	.	.	PUNCT
finefocus-541	173	1	schweizer	schweizer	PROPN
finefocus-541	173	2	,	,	PUNCT
finefocus-541	173	3	h.	h.	PROPN
finefocus-541	173	4	p.	p.	PROPN
finefocus-541	173	5	(	(	PUNCT
finefocus-541	173	6	2012	2012	NUM
finefocus-541	173	7	)	)	PUNCT
finefocus-541	173	8	.	.	PUNCT
finefocus-541	174	1	mechanisms	mechanism	NOUN
finefocus-541	174	2	of	of	ADP
finefocus-541	174	3	antibiotic	antibiotic	ADJ
finefocus-541	174	4	resistance	resistance	NOUN
finefocus-541	174	5	in	in	ADP
finefocus-541	174	6	burkholderia	burkholderia	NOUN
finefocus-541	174	7	pseudomallei	pseudomallei	NOUN
finefocus-541	174	8	:	:	PUNCT
finefocus-541	174	9	implications	implication	NOUN
finefocus-541	174	10	for	for	ADP
finefocus-541	174	11	treatment	treatment	NOUN
finefocus-541	174	12	of	of	ADP
finefocus-541	174	13	melioidosis	melioidosis	NOUN
finefocus-541	174	14	.	.	PUNCT
finefocus-541	175	1	future	future	ADJ
finefocus-541	175	2	microbiol	microbiol	PROPN
finefocus-541	175	3	,	,	PUNCT
finefocus-541	175	4	7(12	7(12	NUM
finefocus-541	175	5	)	)	PUNCT
finefocus-541	175	6	,	,	PUNCT
finefocus-541	175	7	1389	1389	NUM
finefocus-541	175	8	-	-	SYM
finefocus-541	175	9	1399	1399	NUM
finefocus-541	175	10	.	.	PUNCT
finefocus-541	176	1	14	14	NUM
finefocus-541	176	2	.	.	X
finefocus-541	176	3	stevens	stevens	PROPN
finefocus-541	176	4	,	,	PUNCT
finefocus-541	176	5	m.	m.	NOUN
finefocus-541	176	6	p.	p.	PROPN
finefocus-541	176	7	,	,	PUNCT
finefocus-541	176	8	&	&	CCONJ
finefocus-541	176	9	galyov	galyov	PROPN
finefocus-541	176	10	,	,	PUNCT
finefocus-541	176	11	e.	e.	PROPN
finefocus-541	176	12	e.	e.	PROPN
finefocus-541	176	13	(	(	PUNCT
finefocus-541	176	14	2004	2004	NUM
finefocus-541	176	15	)	)	PUNCT
finefocus-541	176	16	.	.	PUNCT
finefocus-541	177	1	exploitation	exploitation	NOUN
finefocus-541	177	2	of	of	ADP
finefocus-541	177	3	host	host	NOUN
finefocus-541	177	4	cells	cell	NOUN
finefocus-541	177	5	by	by	ADP
finefocus-541	177	6	burkholderia	burkholderia	NOUN
finefocus-541	177	7	pseudomallei	pseudomallei	NOUN
finefocus-541	177	8	.	.	PUNCT
finefocus-541	178	1	int	int	PROPN
finefocus-541	178	2	j	j	PROPN
finefocus-541	178	3	med	med	PROPN
finefocus-541	178	4	microbiol	microbiol	PROPN
finefocus-541	178	5	,	,	PUNCT
finefocus-541	178	6	293(7	293(7	NUM
finefocus-541	178	7	-	-	SYM
finefocus-541	178	8	8)	8)	NUM
finefocus-541	178	9	,	,	PUNCT
finefocus-541	178	10	549	549	NUM
finefocus-541	178	11	-	-	SYM
finefocus-541	178	12	555	555	NUM
finefocus-541	178	13	.	.	NOUN
finefocus-541	178	14	15	15	NUM
finefocus-541	178	15	.	.	PUNCT
finefocus-541	179	1	sutton	sutton	PROPN
finefocus-541	179	2	,	,	PUNCT
finefocus-541	179	3	s.	s.	PROPN
finefocus-541	179	4	(	(	PUNCT
finefocus-541	179	5	2011	2011	NUM
finefocus-541	179	6	)	)	PUNCT
finefocus-541	179	7	.	.	PUNCT
finefocus-541	180	1	accuracy	accuracy	NOUN
finefocus-541	180	2	of	of	ADP
finefocus-541	180	3	plate	plate	NOUN
finefocus-541	180	4	counts	count	NOUN
finefocus-541	180	5	.	.	PUNCT
finefocus-541	181	1	journal	journal	NOUN
finefocus-541	181	2	of	of	ADP
finefocus-541	181	3	validation	validation	NOUN
finefocus-541	181	4	technology	technology	NOUN
finefocus-541	181	5	,	,	PUNCT
finefocus-541	181	6	17(no	17(no	NUM
finefocus-541	181	7	3	3	NUM
finefocus-541	181	8	)	)	PUNCT
finefocus-541	181	9	,	,	PUNCT
finefocus-541	181	10	5	5	NUM
finefocus-541	181	11	.	.	SYM
finefocus-541	181	12	16	16	NUM
finefocus-541	181	13	.	.	PUNCT
finefocus-541	182	1	white	white	ADJ
finefocus-541	182	2	,	,	PUNCT
finefocus-541	182	3	n.	n.	PROPN
finefocus-541	182	4	j.	j.	PROPN
finefocus-541	182	5	(	(	PUNCT
finefocus-541	182	6	2003	2003	NUM
finefocus-541	182	7	)	)	PUNCT
finefocus-541	182	8	.	.	PUNCT
finefocus-541	183	1	melioidosis	melioidosis	PROPN
finefocus-541	183	2	.	.	PUNCT
finefocus-541	184	1	lancet	lancet	PROPN
finefocus-541	184	2	,	,	PUNCT
finefocus-541	184	3	361(9370	361(9370	NOUN
finefocus-541	184	4	)	)	PUNCT
finefocus-541	184	5	,	,	PUNCT
finefocus-541	184	6	1715	1715	NUM
finefocus-541	184	7	-	-	SYM
finefocus-541	184	8	1722	1722	NUM
finefocus-541	184	9	.	.	PUNCT
finefocus-541	185	1	17	17	NUM
finefocus-541	185	2	.	.	X
finefocus-541	186	1	wiersinga	wiersinga	PROPN
finefocus-541	186	2	,	,	PUNCT
finefocus-541	186	3	w.	w.	PROPN
finefocus-541	186	4	j.	j.	PROPN
finefocus-541	186	5	,	,	PUNCT
finefocus-541	186	6	van	van	PROPN
finefocus-541	186	7	der	der	PROPN
finefocus-541	186	8	poll	poll	NOUN
finefocus-541	186	9	,	,	PUNCT
finefocus-541	186	10	t.	t.	PROPN
finefocus-541	186	11	,	,	PUNCT
finefocus-541	186	12	white	white	ADJ
finefocus-541	186	13	,	,	PUNCT
finefocus-541	186	14	n.	n.	PROPN
finefocus-541	186	15	j.	j.	PROPN
finefocus-541	186	16	,	,	PUNCT
finefocus-541	186	17	day	day	PROPN
finefocus-541	186	18	,	,	PUNCT
finefocus-541	186	19	n.	n.	PROPN
finefocus-541	186	20	p.	p.	PROPN
finefocus-541	186	21	,	,	PUNCT
finefocus-541	186	22	&	&	CCONJ
finefocus-541	186	23	peacock	peacock	PROPN
finefocus-541	186	24	,	,	PUNCT
finefocus-541	186	25	s.	s.	PROPN
finefocus-541	186	26	j.	j.	PROPN
finefocus-541	186	27	(	(	PUNCT
finefocus-541	186	28	2006	2006	NUM
finefocus-541	186	29	)	)	PUNCT
finefocus-541	186	30	.	.	PUNCT
finefocus-541	187	1	melioidosis	melioidosis	NOUN
finefocus-541	187	2	:	:	PUNCT
finefocus-541	187	3	insights	insight	NOUN
finefocus-541	187	4	into	into	ADP
finefocus-541	187	5	the	the	DET
finefocus-541	187	6	pathogenicity	pathogenicity	NOUN
finefocus-541	187	7	of	of	ADP
finefocus-541	187	8	burkholderia	burkholderia	NOUN
finefocus-541	187	9	pseudomallei	pseudomallei	NOUN
finefocus-541	187	10	.	.	PUNCT
finefocus-541	188	1	nat	nat	PROPN
finefocus-541	188	2	rev	rev	PROPN
finefocus-541	188	3	microbiol	microbiol	PROPN
finefocus-541	188	4	,	,	PUNCT
finefocus-541	188	5	4(4	4(4	NUM
finefocus-541	188	6	)	)	PUNCT
finefocus-541	188	7	,	,	PUNCT
finefocus-541	188	8	272	272	NUM
finefocus-541	188	9	-	-	SYM
finefocus-541	188	10	282	282	NUM
finefocus-541	188	11	.	.	PUNCT
finefocus-541	188	12	18	18	NUM
finefocus-541	188	13	.	.	PUNCT
finefocus-541	189	1	wood	wood	NOUN
finefocus-541	189	2	,	,	PUNCT
finefocus-541	189	3	t.	t.	PROPN
finefocus-541	189	4	k.	k.	PROPN
finefocus-541	189	5	,	,	PUNCT
finefocus-541	189	6	knabel	knabel	PROPN
finefocus-541	189	7	,	,	PUNCT
finefocus-541	189	8	s.	s.	PROPN
finefocus-541	189	9	j.	j.	PROPN
finefocus-541	189	10	,	,	PUNCT
finefocus-541	189	11	&	&	CCONJ
finefocus-541	189	12	kwan	kwan	PROPN
finefocus-541	189	13	,	,	PUNCT
finefocus-541	189	14	b.	b.	PROPN
finefocus-541	189	15	w.	w.	PROPN
finefocus-541	189	16	(	(	PUNCT
finefocus-541	189	17	2013	2013	NUM
finefocus-541	189	18	)	)	PUNCT
finefocus-541	189	19	.	.	PUNCT
finefocus-541	190	1	bacterial	bacterial	ADJ
finefocus-541	190	2	persister	persister	ADJ
finefocus-541	190	3	cell	cell	NOUN
finefocus-541	190	4	formation	formation	NOUN
finefocus-541	190	5	and	and	CCONJ
finefocus-541	190	6	dormancy	dormancy	NOUN
finefocus-541	190	7	.	.	PUNCT
finefocus-541	191	1	appl	appl	PROPN
finefocus-541	191	2	environ	environ	X
finefocus-541	191	3	microbiol	microbiol	PROPN
finefocus-541	191	4	,	,	PUNCT
finefocus-541	191	5	79(23	79(23	NOUN
finefocus-541	191	6	)	)	PUNCT
finefocus-541	191	7	,	,	PUNCT
finefocus-541	191	8	7116	7116	NUM
finefocus-541	191	9	-	-	SYM
finefocus-541	191	10	7121	7121	NUM
finefocus-541	191	11	.	.	PUNCT
finefocus-541	192	1	19	19	NUM
finefocus-541	192	2	.	.	PUNCT
finefocus-541	192	3	wuthiekanun	wuthiekanun	PROPN
finefocus-541	192	4	,	,	PUNCT
finefocus-541	192	5	v.	v.	ADV
finefocus-541	192	6	,	,	PUNCT
finefocus-541	192	7	&	&	CCONJ
finefocus-541	192	8	peacock	peacock	NOUN
finefocus-541	192	9	,	,	PUNCT
finefocus-541	192	10	s.	s.	PROPN
finefocus-541	192	11	j.	j.	PROPN
finefocus-541	192	12	(	(	PUNCT
finefocus-541	192	13	2006	2006	NUM
finefocus-541	192	14	)	)	PUNCT
finefocus-541	192	15	.	.	PUNCT
finefocus-541	193	1	management	management	NOUN
finefocus-541	193	2	of	of	ADP
finefocus-541	193	3	melioidosis	melioidosis	NOUN
finefocus-541	193	4	.	.	PUNCT
finefocus-541	194	1	expert	expert	PROPN
finefocus-541	194	2	rev	rev	VERB
finefocus-541	194	3	anti	anti	PROPN
finefocus-541	194	4	infect	infect	PROPN
finefocus-541	194	5	ther	ther	ADV
finefocus-541	194	6	,	,	PUNCT
finefocus-541	194	7	4(3	4(3	NUM
finefocus-541	194	8	)	)	PUNCT
finefocus-541	194	9	,	,	PUNCT
finefocus-541	194	10	445	445	NUM
finefocus-541	194	11	-	-	SYM
finefocus-541	194	12	455	455	NUM
finefocus-541	194	13	.	.	PUNCT
finefocus-541	195	1	20	20	NUM
finefocus-541	195	2	.	.	PUNCT
finefocus-541	195	3	yi	yi	PROPN
finefocus-541	195	4	,	,	PUNCT
finefocus-541	195	5	h.	h.	PROPN
finefocus-541	195	6	,	,	PUNCT
finefocus-541	195	7	cho	cho	PROPN
finefocus-541	195	8	,	,	PUNCT
finefocus-541	195	9	k.	k.	PROPN
finefocus-541	195	10	h.	h.	PROPN
finefocus-541	195	11	,	,	PUNCT
finefocus-541	195	12	cho	cho	PROPN
finefocus-541	195	13	,	,	PUNCT
finefocus-541	195	14	y.	y.	PROPN
finefocus-541	195	15	s.	s.	PROPN
finefocus-541	195	16	,	,	PUNCT
finefocus-541	195	17	kim	kim	PROPN
finefocus-541	195	18	,	,	PUNCT
finefocus-541	195	19	k.	k.	PROPN
finefocus-541	195	20	,	,	PUNCT
finefocus-541	195	21	nierman	nierman	PROPN
finefocus-541	195	22	,	,	PUNCT
finefocus-541	195	23	w.	w.	PROPN
finefocus-541	195	24	c.	c.	PROPN
finefocus-541	195	25	,	,	PUNCT
finefocus-541	195	26	&	&	CCONJ
finefocus-541	195	27	kim	kim	PROPN
finefocus-541	195	28	,	,	PUNCT
finefocus-541	195	29	h.	h.	PROPN
finefocus-541	195	30	s.	s.	PROPN
finefocus-541	195	31	(	(	PUNCT
finefocus-541	195	32	2012	2012	NUM
finefocus-541	195	33	)	)	PUNCT
finefocus-541	195	34	.	.	PUNCT
finefocus-541	196	1	twelve	twelve	NUM
finefocus-541	196	2	positions	position	NOUN
finefocus-541	196	3	in	in	ADP
finefocus-541	196	4	a	a	DET
finefocus-541	196	5	beta	beta	NOUN
finefocus-541	196	6	-	-	PUNCT
finefocus-541	196	7	lactamase	lactamase	NOUN
finefocus-541	196	8	that	that	PRON
finefocus-541	196	9	can	can	AUX
finefocus-541	196	10	expand	expand	VERB
finefocus-541	196	11	its	its	PRON
finefocus-541	196	12	substrate	substrate	NOUN
finefocus-541	196	13	spectrum	spectrum	NOUN
finefocus-541	196	14	with	with	ADP
finefocus-541	196	15	a	a	DET
finefocus-541	196	16	single	single	ADJ
finefocus-541	196	17	amino	amino	NOUN
finefocus-541	196	18	acid	acid	NOUN
finefocus-541	196	19	substitution	substitution	NOUN
finefocus-541	196	20	.	.	PUNCT
finefocus-541	197	1	plos	plos	PROPN
finefocus-541	197	2	one	one	NUM
finefocus-541	197	3	,	,	PUNCT
finefocus-541	197	4	7(5	7(5	NUM
finefocus-541	197	5	)	)	PUNCT
finefocus-541	197	6	,	,	PUNCT
finefocus-541	197	7	e37585	e37585	PROPN
finefocus-541	197	8	.	.	PUNCT