id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
fnp-2955	Manousopoulou, Antigoni; Yuen, Ho Ming; MacGregor Sharp, Matt; Saito, Satoshi; Aldea, Roxana; Mazer, Norman; Garbis, Spiros D; Carare, Roxana O	Quantitative proteomic profiling of white matter in cases of cerebral amyloid angiopathy reveals upregulation of extracellular matrix proteins and clusterin	2020		.htm	application/xhtml+xml	5559	390	52	Downregulated proteins included DSP, IDE, HBG1. Conclusions: The present study reports an in-depth quantitative proteomic profiling of white matter from patients with CAA, highlighting extracellular matrix proteins and clusterin as key molecules in the pathophysiology of white matter changes in cases of CAA. Introduction Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid proteins including amyloid beta (Aβ), cystatin C, prion protein, ABri/ADan, transthyretin, gelsolin and immunoglobulin light chain amyloid (1) in the walls of leptomenigeal arteries and cortical arterioles (CAA-Type 2) (2) and in the walls of arteries or capillaries (CAA-Type 1), but rarely in the walls of venules (1-3).	cache/fnp-2955.htm	txt/fnp-2955.txt