id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
fnp-3459	Boche, Delphine; Nicoll, James AR	Hypothesis: Entrapment of lipoprotein particles in the brain causes Alzheimer’s disease	2021		.htm	application/xhtml+xml	6188	411	49	Impaired movement of lipoprotein particles in the extracellular space in the brain in ageing is central to and causes all the key pathophysiological features of Alzheimer’s disease: degeneration of entrapped lipoprotein particles releases Aβ which aggregates in the aqueous environment of the extracellular space; a microglial reaction to the Aβ results in secretion of neurotoxic substances; neuronal cholesterol deficiency causes intraneuronal tau accumulation. Hypothesis: Entrapment of lipoprotein particles in the brain causes Alzheimer’s disease Feel free to add comments by clicking these icons on the sidebar Free Neuropathology 2:30 (2021) Opinion Piece Hypothesis: Entrapment of lipoprotein particles in the brain causes Alzheimer’s disease Delphine Boche1, James AR Nicoll1,2 1 Clinical Neurosciences, Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, United Kingdom 2 Department of Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom Corresponding author: Delphine Boche · Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit · Faculty of Medicine · University of Southampton · Southampton General Hospital · Mailpoint 806 ·	cache/fnp-3459.htm	txt/fnp-3459.txt