id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
fnp-5398	Dundar, Bilge; Agac, Busranur; Alzayadneh, Eyas; Tashjian, Randy; Conway, Kyle	The presence of shrunken neurons with pyknotic nuclei in the dentate nucleus is a common postmortem change associated with autolysis of the cerebellar granular cell layer	2024		.htm	application/xhtml+xml	1985	100	45	Age 0.97 < 0.01 Male 1.20 0.18 Neuropathologic features (n = 81) Granular cell layer autolysis (severity; 0 - 3) -1.65 < 0.01 Postmortem interval (24 hours) -0.65 0.12 Cerebellar arteriolosclerosis (severity; 0 - 3) -0.03 0.94 Hypoxic-ischemic injury (present/absent) -0.65 0.52 Neurodegenerative disease (present/absent) 2.91 < 0.01 Clinicopathologic features (n = 53) Acute liver failure (present/absent) -4.39 < 0.01 Chronic liver disease (present/absent) -1.93 0.15 Acute kidney injury (present/absent) -1.15 0.26 Chronic kidney disease (present/absent) 1.44 0.22 Diffuse alveolar damage (present/absent) -2.05 0.85 History of smoking (present/absent) -1.03 0.31 History of hypertension (present/absent) -1.54 0.19 Heart weight (per 100 grams) 0.00 0.30 History of diabetes (present/absent) -2.29 0.03 The fact that both significant clinicopathologic relationships – acute liver injury and a history of diabetes – appear to be also associated with GCA suggests that these clinical states predispose decedents to cerebellar autolytic change. The diameter of DN neuronal cell bodies may provide a measurable proxy for cerebellar autolysis to assist in semi-quantitative assessment of GCA.	cache/fnp-5398.htm	txt/fnp-5398.txt