id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
fnp-5809	Mittelbronn, Michel	Neurooncology: 2024 update	2024		.htm	application/xhtml+xml	8671	442	46	Regarding the understanding of brain tumor development and progression, several novel mechanisms have been presented which might also be considered as treatment targets in the future, such as a) autonomous rhythmical Ca2+ oscillations in interconnected glioma cell networks driving tumor growth; b) transfer of mitochondria from normal astrocytes to glioma cells enhancing proliferation and self-renewal; c) brain endothelial cell remodeling upon matrix-metalloprotease 9 secretion by tumor cells metastasizing into the CNS and d) anti-tumor activity of microglia in CNS metastasis of breast cancer. Once cancer cells successfully extravasated and started perivascular metastatic growth, prominent endothelial cell remodeling led to the formation of capillary loops that followed the localization of tumor cells.	cache/fnp-5809.htm	txt/fnp-5809.txt