id	sid	tid	token	lemma	pos
fnp-2615	1	1	top	top	ADJ
fnp-2615	1	2	ten	ten	NUM
fnp-2615	1	3	discoveries	discovery	NOUN
fnp-2615	1	4	of	of	ADP
fnp-2615	1	5	the	the	DET
fnp-2615	1	6	year	year	NOUN
fnp-2615	1	7	:	:	PUNCT
fnp-2615	1	8	neurovascular	neurovascular	ADJ
fnp-2615	1	9	disease	disease	NOUN
fnp-2615	1	10	feel	feel	VERB
fnp-2615	1	11	free	free	ADJ
fnp-2615	1	12	to	to	PART
fnp-2615	1	13	add	add	VERB
fnp-2615	1	14	comments	comment	NOUN
fnp-2615	1	15	by	by	ADP
fnp-2615	1	16	clicking	click	VERB
fnp-2615	1	17	these	these	DET
fnp-2615	1	18	icons	icon	NOUN
fnp-2615	1	19	on	on	ADP
fnp-2615	1	20	the	the	DET
fnp-2615	1	21	sidebar	sidebar	NOUN
fnp-2615	1	22	free	free	PROPN
fnp-2615	1	23	neuropathology	neuropathology	PROPN
fnp-2615	1	24	1:5	1:5	NUM
fnp-2615	1	25	(	(	PUNCT
fnp-2615	1	26	2020	2020	NUM
fnp-2615	1	27	)	)	PUNCT
fnp-2615	1	28	review	review	VERB
fnp-2615	1	29	top	top	ADJ
fnp-2615	1	30	ten	ten	NUM
fnp-2615	1	31	discoveries	discovery	NOUN
fnp-2615	1	32	of	of	ADP
fnp-2615	1	33	the	the	DET
fnp-2615	1	34	year	year	NOUN
fnp-2615	1	35	:	:	PUNCT
fnp-2615	1	36	neurovascular	neurovascular	ADJ
fnp-2615	1	37	disease	disease	NOUN
fnp-2615	1	38	anna	anna	PROPN
fnp-2615	1	39	m.	m.	PROPN
fnp-2615	1	40	planas	planas	PROPN
fnp-2615	1	41	department	department	PROPN
fnp-2615	1	42	of	of	ADP
fnp-2615	1	43	brain	brain	NOUN
fnp-2615	1	44	ischemia	ischemia	NOUN
fnp-2615	1	45	and	and	CCONJ
fnp-2615	1	46	neurodegeneration	neurodegeneration	NOUN
fnp-2615	1	47	,	,	PUNCT
fnp-2615	1	48	spanish	spanish	ADJ
fnp-2615	1	49	national	national	PROPN
fnp-2615	1	50	research	research	PROPN
fnp-2615	1	51	council	council	PROPN
fnp-2615	1	52	(	(	PUNCT
fnp-2615	1	53	csic	csic	PROPN
fnp-2615	1	54	)	)	PUNCT
fnp-2615	1	55	,	,	PUNCT
fnp-2615	1	56	barcelona	barcelona	PROPN
fnp-2615	1	57	,	,	PUNCT
fnp-2615	1	58	spain	spain	PROPN
fnp-2615	1	59	corresponding	corresponding	PROPN
fnp-2615	1	60	author	author	PROPN
fnp-2615	1	61	:	:	PUNCT
fnp-2615	1	62	anna	anna	PROPN
fnp-2615	1	63	m.	m.	PROPN
fnp-2615	1	64	planas	planas	PROPN
fnp-2615	1	65	·	·	PUNCT
fnp-2615	1	66	department	department	NOUN
fnp-2615	1	67	of	of	ADP
fnp-2615	1	68	brain	brain	NOUN
fnp-2615	1	69	ischemia	ischemia	NOUN
fnp-2615	1	70	and	and	CCONJ
fnp-2615	1	71	neurodegeneration	neurodegeneration	NOUN
fnp-2615	1	72	·	·	PUNCT
fnp-2615	1	73	institute	institute	NOUN
fnp-2615	1	74	for	for	ADP
fnp-2615	1	75	biomedical	biomedical	ADJ
fnp-2615	1	76	research	research	NOUN
fnp-2615	1	77	of	of	ADP
fnp-2615	1	78	barcelona	barcelona	PROPN
fnp-2615	1	79	(	(	PUNCT
fnp-2615	1	80	iibb	iibb	PROPN
fnp-2615	1	81	)	)	PUNCT
fnp-2615	1	82	·	·	PUNCT
fnp-2615	1	83	spanish	spanish	ADJ
fnp-2615	1	84	national	national	PROPN
fnp-2615	1	85	research	research	PROPN
fnp-2615	1	86	council	council	PROPN
fnp-2615	1	87	(	(	PUNCT
fnp-2615	1	88	csic	csic	PROPN
fnp-2615	1	89	)	)	PUNCT
fnp-2615	1	90	·	·	PUNCT
fnp-2615	1	91	institute	institute	NOUN
fnp-2615	1	92	for	for	ADP
fnp-2615	1	93	biomedical	biomedical	ADJ
fnp-2615	1	94	research	research	NOUN
fnp-2615	1	95	august	august	PROPN
fnp-2615	1	96	pi	pi	NOUN
fnp-2615	2	1	i	i	PRON
fnp-2615	2	2	sunyer	sunyer	NOUN
fnp-2615	2	3	(	(	PUNCT
fnp-2615	2	4	idibaps	idibap	NOUN
fnp-2615	2	5	)	)	PUNCT
fnp-2615	2	6	·	·	PUNCT
fnp-2615	2	7	rosselló	rosselló	VERB
fnp-2615	2	8	161	161	NUM
fnp-2615	2	9	·	·	PUNCT
fnp-2615	2	10	planta	planta	NOUN
fnp-2615	2	11	6	6	NUM
fnp-2615	2	12	·	·	SYM
fnp-2615	2	13	08036	08036	NUM
fnp-2615	2	14	-	-	SYM
fnp-2615	2	15	barcelona	barcelona	PROPN
fnp-2615	2	16	·	·	PUNCT
fnp-2615	2	17	spain	spain	PROPN
fnp-2615	2	18	anna.planas@iibb.csic.es	anna.planas@iibb.csic.es	ADV
fnp-2615	2	19	submitted	submit	VERB
fnp-2615	2	20	:	:	PUNCT
fnp-2615	2	21	09	09	NUM
fnp-2615	2	22	january	january	NOUN
fnp-2615	2	23	2020	2020	NUM
fnp-2615	2	24	accepted	accept	VERB
fnp-2615	2	25	:	:	PUNCT
fnp-2615	2	26	25	25	NUM
fnp-2615	2	27	january	january	PROPN
fnp-2615	2	28	2020	2020	NUM
fnp-2615	2	29	published	publish	VERB
fnp-2615	2	30	:	:	PUNCT
fnp-2615	3	1	30	30	NUM
fnp-2615	3	2	january	january	PROPN
fnp-2615	3	3	2020	2020	NUM
fnp-2615	3	4	https://doi.org/10.17879/freeneuropathology-2020-2615	https://doi.org/10.17879/freeneuropathology-2020-2615	X
fnp-2615	3	5	abstract	abstract	NOUN
fnp-2615	3	6	the	the	DET
fnp-2615	3	7	aim	aim	NOUN
fnp-2615	3	8	of	of	ADP
fnp-2615	3	9	this	this	DET
fnp-2615	3	10	review	review	NOUN
fnp-2615	3	11	is	be	AUX
fnp-2615	3	12	to	to	PART
fnp-2615	3	13	highlight	highlight	VERB
fnp-2615	3	14	novel	novel	ADJ
fnp-2615	3	15	findings	finding	NOUN
fnp-2615	3	16	in	in	ADP
fnp-2615	3	17	2019	2019	NUM
fnp-2615	3	18	in	in	ADP
fnp-2615	3	19	the	the	DET
fnp-2615	3	20	area	area	NOUN
fnp-2615	3	21	of	of	ADP
fnp-2615	3	22	neurovascular	neurovascular	ADJ
fnp-2615	3	23	disease	disease	NOUN
fnp-2615	3	24	.	.	PUNCT
fnp-2615	4	1	experimental	experimental	ADJ
fnp-2615	4	2	studies	study	NOUN
fnp-2615	4	3	have	have	AUX
fnp-2615	4	4	provided	provide	VERB
fnp-2615	4	5	insight	insight	NOUN
fnp-2615	4	6	into	into	ADP
fnp-2615	4	7	disease	disease	NOUN
fnp-2615	4	8	development	development	NOUN
fnp-2615	4	9	,	,	PUNCT
fnp-2615	4	10	molecular	molecular	ADJ
fnp-2615	4	11	determinants	determinant	NOUN
fnp-2615	4	12	of	of	ADP
fnp-2615	4	13	pathology	pathology	NOUN
fnp-2615	4	14	,	,	PUNCT
fnp-2615	4	15	and	and	CCONJ
fnp-2615	4	16	putative	putative	ADJ
fnp-2615	4	17	novel	novel	ADJ
fnp-2615	4	18	therapeutic	therapeutic	ADJ
fnp-2615	4	19	targets	target	NOUN
fnp-2615	4	20	.	.	PUNCT
fnp-2615	5	1	studies	study	NOUN
fnp-2615	5	2	in	in	ADP
fnp-2615	5	3	genetic	genetic	ADJ
fnp-2615	5	4	experimental	experimental	ADJ
fnp-2615	5	5	models	model	NOUN
fnp-2615	5	6	as	as	ADV
fnp-2615	5	7	well	well	ADV
fnp-2615	5	8	as	as	ADP
fnp-2615	5	9	monogenic	monogenic	ADJ
fnp-2615	5	10	forms	form	NOUN
fnp-2615	5	11	of	of	ADP
fnp-2615	5	12	human	human	ADJ
fnp-2615	5	13	cerebrovascular	cerebrovascular	ADJ
fnp-2615	5	14	diseases	disease	NOUN
fnp-2615	5	15	identified	identify	VERB
fnp-2615	5	16	pathogenic	pathogenic	ADJ
fnp-2615	5	17	molecules	molecule	NOUN
fnp-2615	5	18	that	that	PRON
fnp-2615	5	19	may	may	AUX
fnp-2615	5	20	also	also	ADV
fnp-2615	5	21	be	be	AUX
fnp-2615	5	22	relevant	relevant	ADJ
fnp-2615	5	23	to	to	ADP
fnp-2615	5	24	sporadic	sporadic	ADJ
fnp-2615	5	25	cases	case	NOUN
fnp-2615	5	26	.	.	PUNCT
fnp-2615	6	1	there	there	PRON
fnp-2615	6	2	have	have	AUX
fnp-2615	6	3	been	be	AUX
fnp-2615	6	4	advances	advance	NOUN
fnp-2615	6	5	in	in	ADP
fnp-2615	6	6	understanding	understand	VERB
fnp-2615	6	7	the	the	DET
fnp-2615	6	8	development	development	NOUN
fnp-2615	6	9	of	of	ADP
fnp-2615	6	10	cerebral	cerebral	ADJ
fnp-2615	6	11	cavernous	cavernous	ADJ
fnp-2615	6	12	angiomas	angioma	NOUN
fnp-2615	6	13	and	and	CCONJ
fnp-2615	6	14	arteriovenous	arteriovenous	ADJ
fnp-2615	6	15	malformations	malformation	NOUN
fnp-2615	6	16	,	,	PUNCT
fnp-2615	6	17	and	and	CCONJ
fnp-2615	6	18	putative	putative	ADJ
fnp-2615	6	19	curative	curative	ADJ
fnp-2615	6	20	treatments	treatment	NOUN
fnp-2615	6	21	have	have	AUX
fnp-2615	6	22	been	be	AUX
fnp-2615	6	23	suggested	suggest	VERB
fnp-2615	6	24	from	from	ADP
fnp-2615	6	25	experimental	experimental	ADJ
fnp-2615	6	26	models	model	NOUN
fnp-2615	6	27	.	.	PUNCT
fnp-2615	7	1	key	key	ADJ
fnp-2615	7	2	pathogenic	pathogenic	ADJ
fnp-2615	7	3	pathways	pathway	NOUN
fnp-2615	7	4	involved	involve	VERB
fnp-2615	7	5	in	in	ADP
fnp-2615	7	6	vessel	vessel	ADJ
fnp-2615	7	7	calcification	calcification	NOUN
fnp-2615	7	8	and	and	CCONJ
fnp-2615	7	9	stiffness	stiffness	NOUN
fnp-2615	7	10	have	have	AUX
fnp-2615	7	11	also	also	ADV
fnp-2615	7	12	been	be	AUX
fnp-2615	7	13	identified	identify	VERB
fnp-2615	7	14	.	.	PUNCT
fnp-2615	8	1	at	at	ADP
fnp-2615	8	2	the	the	DET
fnp-2615	8	3	cellular	cellular	ADJ
fnp-2615	8	4	level	level	NOUN
fnp-2615	8	5	,	,	PUNCT
fnp-2615	8	6	studies	study	NOUN
fnp-2615	8	7	showed	show	VERB
fnp-2615	8	8	that	that	SCONJ
fnp-2615	8	9	proper	proper	ADJ
fnp-2615	8	10	function	function	NOUN
fnp-2615	8	11	of	of	ADP
fnp-2615	8	12	endothelial	endothelial	ADJ
fnp-2615	8	13	and	and	CCONJ
fnp-2615	8	14	mural	mural	ADJ
fnp-2615	8	15	cells	cell	NOUN
fnp-2615	8	16	,	,	PUNCT
fnp-2615	8	17	particularly	particularly	ADV
fnp-2615	8	18	pericytes	pericyte	NOUN
fnp-2615	8	19	,	,	PUNCT
fnp-2615	8	20	is	be	AUX
fnp-2615	8	21	crucial	crucial	ADJ
fnp-2615	8	22	to	to	PART
fnp-2615	8	23	ensure	ensure	VERB
fnp-2615	8	24	full	full	ADJ
fnp-2615	8	25	endothelial	endothelial	ADJ
fnp-2615	8	26	differentiation	differentiation	NOUN
fnp-2615	8	27	and	and	CCONJ
fnp-2615	8	28	blood	blood	NOUN
fnp-2615	8	29	-	-	PUNCT
fnp-2615	8	30	brain	brain	NOUN
fnp-2615	8	31	barrier	barrier	NOUN
fnp-2615	8	32	integrity	integrity	NOUN
fnp-2615	8	33	.	.	PUNCT
fnp-2615	9	1	moreover	moreover	ADV
fnp-2615	9	2	,	,	PUNCT
fnp-2615	9	3	recent	recent	ADJ
fnp-2615	9	4	discoveries	discovery	NOUN
fnp-2615	9	5	support	support	VERB
fnp-2615	9	6	the	the	DET
fnp-2615	9	7	existence	existence	NOUN
fnp-2615	9	8	of	of	ADP
fnp-2615	9	9	a	a	DET
fnp-2615	9	10	homeostatic	homeostatic	ADJ
fnp-2615	9	11	crosstalk	crosstalk	NOUN
fnp-2615	9	12	between	between	ADP
fnp-2615	9	13	vascular	vascular	ADJ
fnp-2615	9	14	cells	cell	NOUN
fnp-2615	9	15	and	and	CCONJ
fnp-2615	9	16	other	other	ADJ
fnp-2615	9	17	neural	neural	ADJ
fnp-2615	9	18	cells	cell	NOUN
fnp-2615	9	19	,	,	PUNCT
fnp-2615	9	20	including	include	VERB
fnp-2615	9	21	neurons	neuron	NOUN
fnp-2615	9	22	.	.	PUNCT
fnp-2615	10	1	cerebrovascular	cerebrovascular	ADJ
fnp-2615	10	2	diseases	disease	NOUN
fnp-2615	10	3	are	be	AUX
fnp-2615	10	4	strongly	strongly	ADV
fnp-2615	10	5	associated	associate	VERB
fnp-2615	10	6	with	with	ADP
fnp-2615	10	7	inflammation	inflammation	NOUN
fnp-2615	10	8	.	.	PUNCT
fnp-2615	11	1	beyond	beyond	ADP
fnp-2615	11	2	pathogenic	pathogenic	ADJ
fnp-2615	11	3	roles	role	NOUN
fnp-2615	11	4	of	of	ADP
fnp-2615	11	5	specific	specific	ADJ
fnp-2615	11	6	components	component	NOUN
fnp-2615	11	7	of	of	ADP
fnp-2615	11	8	the	the	DET
fnp-2615	11	9	inflammatory	inflammatory	ADJ
fnp-2615	11	10	response	response	NOUN
fnp-2615	11	11	,	,	PUNCT
fnp-2615	11	12	new	new	ADJ
fnp-2615	11	13	discoveries	discovery	NOUN
fnp-2615	11	14	showed	show	VERB
fnp-2615	11	15	interesting	interesting	ADJ
fnp-2615	11	16	interactions	interaction	NOUN
fnp-2615	11	17	between	between	ADP
fnp-2615	11	18	inflammatory	inflammatory	ADJ
fnp-2615	11	19	molecules	molecule	NOUN
fnp-2615	11	20	and	and	CCONJ
fnp-2615	11	21	regulators	regulator	NOUN
fnp-2615	11	22	of	of	ADP
fnp-2615	11	23	vascular	vascular	ADJ
fnp-2615	11	24	function	function	NOUN
fnp-2615	11	25	.	.	PUNCT
fnp-2615	12	1	clinical	clinical	ADJ
fnp-2615	12	2	investigation	investigation	NOUN
fnp-2615	12	3	on	on	ADP
fnp-2615	12	4	cerebrovascular	cerebrovascular	ADJ
fnp-2615	12	5	diseases	disease	NOUN
fnp-2615	12	6	has	have	AUX
fnp-2615	12	7	progressed	progress	VERB
fnp-2615	12	8	by	by	ADP
fnp-2615	12	9	combining	combine	VERB
fnp-2615	12	10	advanced	advanced	ADJ
fnp-2615	12	11	imaging	imaging	NOUN
fnp-2615	12	12	and	and	CCONJ
fnp-2615	12	13	genome	genome	NOUN
fnp-2615	12	14	-	-	PUNCT
fnp-2615	12	15	wide	wide	ADJ
fnp-2615	12	16	association	association	NOUN
fnp-2615	12	17	studies	study	NOUN
fnp-2615	12	18	.	.	PUNCT
fnp-2615	13	1	finally	finally	ADV
fnp-2615	13	2	,	,	PUNCT
fnp-2615	13	3	vascular	vascular	ADJ
fnp-2615	13	4	cognitive	cognitive	ADJ
fnp-2615	13	5	impairment	impairment	NOUN
fnp-2615	13	6	and	and	CCONJ
fnp-2615	13	7	dementia	dementia	NOUN
fnp-2615	13	8	are	be	AUX
fnp-2615	13	9	receiving	receive	VERB
fnp-2615	13	10	increasing	increase	VERB
fnp-2615	13	11	attention	attention	NOUN
fnp-2615	13	12	.	.	PUNCT
fnp-2615	14	1	recent	recent	ADJ
fnp-2615	14	2	findings	finding	NOUN
fnp-2615	14	3	suggest	suggest	VERB
fnp-2615	14	4	that	that	SCONJ
fnp-2615	14	5	high	high	ADJ
fnp-2615	14	6	-	-	PUNCT
fnp-2615	14	7	salt	salt	NOUN
fnp-2615	14	8	intake	intake	NOUN
fnp-2615	14	9	may	may	AUX
fnp-2615	14	10	cause	cause	VERB
fnp-2615	14	11	cerebrovascular	cerebrovascular	ADJ
fnp-2615	14	12	dysfunction	dysfunction	NOUN
fnp-2615	14	13	and	and	CCONJ
fnp-2615	14	14	cognitive	cognitive	ADJ
fnp-2615	14	15	impairment	impairment	NOUN
fnp-2615	14	16	independent	independent	ADJ
fnp-2615	14	17	of	of	ADP
fnp-2615	14	18	hypoperfusion	hypoperfusion	NOUN
fnp-2615	14	19	and	and	CCONJ
fnp-2615	14	20	hypertension	hypertension	NOUN
fnp-2615	14	21	.	.	PUNCT
fnp-2615	15	1	these	these	PRON
fnp-2615	15	2	and	and	CCONJ
fnp-2615	15	3	other	other	ADJ
fnp-2615	15	4	recent	recent	ADJ
fnp-2615	15	5	reports	report	NOUN
fnp-2615	15	6	will	will	AUX
fnp-2615	15	7	surely	surely	ADV
fnp-2615	15	8	inspire	inspire	VERB
fnp-2615	15	9	further	further	ADJ
fnp-2615	15	10	research	research	NOUN
fnp-2615	15	11	in	in	ADP
fnp-2615	15	12	the	the	DET
fnp-2615	15	13	field	field	NOUN
fnp-2615	15	14	of	of	ADP
fnp-2615	15	15	cerebrovascular	cerebrovascular	ADJ
fnp-2615	15	16	disease	disease	NOUN
fnp-2615	15	17	that	that	PRON
fnp-2615	15	18	will	will	AUX
fnp-2615	15	19	hopefully	hopefully	ADV
fnp-2615	15	20	contribute	contribute	VERB
fnp-2615	15	21	to	to	ADP
fnp-2615	15	22	improved	improved	ADJ
fnp-2615	15	23	prevention	prevention	NOUN
fnp-2615	15	24	and	and	CCONJ
fnp-2615	15	25	treatment	treatment	NOUN
fnp-2615	15	26	.	.	PUNCT
fnp-2615	16	1	abbreviations	abbreviation	NOUN
fnp-2615	16	2	apoe	apoe	VERB
fnp-2615	16	3	,	,	PUNCT
fnp-2615	16	4	apolipoprotein	apolipoprotein	ADJ
fnp-2615	16	5	e	e	NOUN
fnp-2615	16	6	;	;	PUNCT
fnp-2615	16	7	avm	avm	PROPN
fnp-2615	16	8	,	,	PUNCT
fnp-2615	16	9	arteriovenous	arteriovenous	ADJ
fnp-2615	16	10	malformations	malformation	NOUN
fnp-2615	16	11	;	;	PUNCT
fnp-2615	16	12	bbb	bbb	NUM
fnp-2615	16	13	,	,	PUNCT
fnp-2615	16	14	blood	blood	NOUN
fnp-2615	16	15	-	-	PUNCT
fnp-2615	16	16	brain	brain	NOUN
fnp-2615	16	17	barrier	barrier	NOUN
fnp-2615	16	18	;	;	PUNCT
fnp-2615	16	19	caa	caa	NOUN
fnp-2615	16	20	,	,	PUNCT
fnp-2615	16	21	cerebral	cerebral	ADJ
fnp-2615	16	22	amyloid	amyloid	NOUN
fnp-2615	16	23	angiopathy	angiopathy	NOUN
fnp-2615	16	24	;	;	PUNCT
fnp-2615	16	25	cadasil	cadasil	NOUN
fnp-2615	16	26	,	,	PUNCT
fnp-2615	16	27	cerebral	cerebral	ADJ
fnp-2615	16	28	autosomal	autosomal	ADJ
fnp-2615	16	29	dominant	dominant	ADJ
fnp-2615	16	30	arteriopathy	arteriopathy	NOUN
fnp-2615	16	31	with	with	ADP
fnp-2615	16	32	subcortical	subcortical	ADJ
fnp-2615	16	33	infarcts	infarct	NOUN
fnp-2615	16	34	and	and	CCONJ
fnp-2615	16	35	leukoencephalopathy	leukoencephalopathy	NOUN
fnp-2615	16	36	;	;	PUNCT
fnp-2615	16	37	carasil	carasil	NOUN
fnp-2615	16	38	,	,	PUNCT
fnp-2615	16	39	cerebral	cerebral	ADJ
fnp-2615	16	40	autosomal	autosomal	ADJ
fnp-2615	16	41	recessive	recessive	ADJ
fnp-2615	16	42	arteriopathy	arteriopathy	NOUN
fnp-2615	16	43	with	with	ADP
fnp-2615	16	44	subcortical	subcortical	ADJ
fnp-2615	16	45	infarcts	infarct	NOUN
fnp-2615	16	46	and	and	CCONJ
fnp-2615	16	47	leukoencephalopathy	leukoencephalopathy	ADJ
fnp-2615	16	48	;	;	PUNCT
fnp-2615	16	49	cbf	cbf	PROPN
fnp-2615	16	50	,	,	PUNCT
fnp-2615	16	51	cerebral	cerebral	ADJ
fnp-2615	16	52	blood	blood	NOUN
fnp-2615	16	53	flow	flow	NOUN
fnp-2615	16	54	;	;	PUNCT
fnp-2615	16	55	ccm	ccm	NOUN
fnp-2615	16	56	,	,	PUNCT
fnp-2615	16	57	cerebral	cerebral	ADJ
fnp-2615	16	58	cavernous	cavernous	ADJ
fnp-2615	16	59	angiomas	angioma	NOUN
fnp-2615	16	60	;	;	PUNCT
fnp-2615	16	61	cdk5	cdk5	PROPN
fnp-2615	16	62	,	,	PUNCT
fnp-2615	16	63	cyclin	cyclin	NOUN
fnp-2615	16	64	-	-	PUNCT
fnp-2615	16	65	dependent	dependent	ADJ
fnp-2615	16	66	kinase	kinase	NOUN
fnp-2615	16	67	5	5	NUM
fnp-2615	16	68	;	;	PUNCT
fnp-2615	16	69	dti	dti	PROPN
fnp-2615	16	70	,	,	PUNCT
fnp-2615	16	71	diffusion	diffusion	NOUN
fnp-2615	16	72	tensor	tensor	NOUN
fnp-2615	16	73	imaging	imaging	NOUN
fnp-2615	16	74	;	;	PUNCT
fnp-2615	16	75	endmt	endmt	ADJ
fnp-2615	16	76	,	,	PUNCT
fnp-2615	16	77	endothelial	endothelial	NOUN
fnp-2615	16	78	-	-	PUNCT
fnp-2615	16	79	to	to	ADP
fnp-2615	16	80	-	-	PUNCT
fnp-2615	16	81	mesenchymal	mesenchymal	NOUN
fnp-2615	16	82	transition	transition	NOUN
fnp-2615	16	83	;	;	PUNCT
fnp-2615	16	84	gom	gom	NOUN
fnp-2615	16	85	,	,	PUNCT
fnp-2615	16	86	granular	granular	ADJ
fnp-2615	16	87	osmiophilic	osmiophilic	NOUN
fnp-2615	16	88	material	material	NOUN
fnp-2615	16	89	;	;	PUNCT
fnp-2615	16	90	ipscs	ipsc	NOUN
fnp-2615	16	91	,	,	PUNCT
fnp-2615	16	92	induced	induce	VERB
fnp-2615	16	93	pluripotent	pluripotent	ADJ
fnp-2615	16	94	stem	stem	NOUN
fnp-2615	16	95	cells	cell	NOUN
fnp-2615	16	96	;	;	PUNCT
fnp-2615	16	97	pdgfb	pdgfb	ADJ
fnp-2615	16	98	,	,	PUNCT
fnp-2615	16	99	platelet	platelet	ADJ
fnp-2615	16	100	-	-	PUNCT
fnp-2615	16	101	derived	derive	VERB
fnp-2615	16	102	growth	growth	NOUN
fnp-2615	16	103	factor	factor	NOUN
fnp-2615	16	104	subunit	subunit	NOUN
fnp-2615	16	105	β	β	NOUN
fnp-2615	16	106	;	;	PUNCT
fnp-2615	16	107	pfbc	pfbc	VERB
fnp-2615	16	108	,	,	PUNCT
fnp-2615	16	109	primary	primary	ADJ
fnp-2615	16	110	familial	familial	ADJ
fnp-2615	16	111	brain	brain	NOUN
fnp-2615	16	112	calcification	calcification	NOUN
fnp-2615	16	113	,	,	PUNCT
fnp-2615	16	114	fahr	fahr	PROPN
fnp-2615	16	115	’s	’s	PART
fnp-2615	16	116	disease	disease	NOUN
fnp-2615	16	117	;	;	PUNCT
fnp-2615	16	118	sah	sah	NOUN
fnp-2615	16	119	,	,	PUNCT
fnp-2615	16	120	subarachnoid	subarachnoid	VERB
fnp-2615	16	121	hemorrhage	hemorrhage	NOUN
fnp-2615	16	122	;	;	PUNCT
fnp-2615	16	123	smcs	smcs	ADJ
fnp-2615	16	124	,	,	PUNCT
fnp-2615	16	125	smooth	smooth	ADJ
fnp-2615	16	126	muscle	muscle	NOUN
fnp-2615	16	127	cells	cell	NOUN
fnp-2615	16	128	;	;	PUNCT
fnp-2615	16	129	timp3	timp3	NOUN
fnp-2615	16	130	,	,	PUNCT
fnp-2615	16	131	tissue	tissue	NOUN
fnp-2615	16	132	inhibitor	inhibitor	NOUN
fnp-2615	16	133	of	of	ADP
fnp-2615	16	134	metalloproteinase	metalloproteinase	PROPN
fnp-2615	16	135	3	3	NUM
fnp-2615	16	136	;	;	PUNCT
fnp-2615	16	137	tgfβ	tgfβ	ADJ
fnp-2615	16	138	,	,	PUNCT
fnp-2615	16	139	transforming	transform	VERB
fnp-2615	16	140	growth	growth	NOUN
fnp-2615	16	141	factor	factor	NOUN
fnp-2615	16	142	-	-	PUNCT
fnp-2615	16	143	β	β	NOUN
fnp-2615	16	144	introduction	introduction	NOUN
fnp-2615	16	145	in	in	ADP
fnp-2615	16	146	the	the	DET
fnp-2615	16	147	next	next	ADJ
fnp-2615	16	148	pages	page	NOUN
fnp-2615	16	149	i	i	PRON
fnp-2615	16	150	will	will	AUX
fnp-2615	16	151	discuss	discuss	VERB
fnp-2615	16	152	a	a	DET
fnp-2615	16	153	few	few	ADJ
fnp-2615	16	154	topics	topic	NOUN
fnp-2615	16	155	in	in	ADP
fnp-2615	16	156	the	the	DET
fnp-2615	16	157	field	field	NOUN
fnp-2615	16	158	of	of	ADP
fnp-2615	16	159	cerebrovascular	cerebrovascular	ADJ
fnp-2615	16	160	disease	disease	NOUN
fnp-2615	16	161	that	that	PRON
fnp-2615	16	162	i	i	PRON
fnp-2615	16	163	believe	believe	VERB
fnp-2615	16	164	have	have	AUX
fnp-2615	16	165	made	make	VERB
fnp-2615	16	166	advances	advance	NOUN
fnp-2615	16	167	in	in	ADP
fnp-2615	16	168	2019	2019	NUM
fnp-2615	16	169	supported	support	VERB
fnp-2615	16	170	by	by	ADP
fnp-2615	16	171	excellent	excellent	ADJ
fnp-2615	16	172	studies	study	NOUN
fnp-2615	16	173	covering	cover	VERB
fnp-2615	16	174	genetic	genetic	ADJ
fnp-2615	16	175	and	and	CCONJ
fnp-2615	16	176	sporadic	sporadic	ADJ
fnp-2615	16	177	forms	form	NOUN
fnp-2615	16	178	of	of	ADP
fnp-2615	16	179	the	the	DET
fnp-2615	16	180	diseases	disease	NOUN
fnp-2615	16	181	in	in	ADP
fnp-2615	16	182	humans	human	NOUN
fnp-2615	16	183	and	and	CCONJ
fnp-2615	16	184	experimental	experimental	ADJ
fnp-2615	16	185	animals	animal	NOUN
fnp-2615	16	186	.	.	PUNCT
fnp-2615	17	1	1	1	X
fnp-2615	17	2	.	.	X
fnp-2615	17	3	cavernous	cavernous	ADJ
fnp-2615	17	4	angiomas	angioma	NOUN
fnp-2615	17	5	originate	originate	VERB
fnp-2615	17	6	from	from	ADP
fnp-2615	17	7	clonal	clonal	ADJ
fnp-2615	17	8	expansion	expansion	NOUN
fnp-2615	17	9	of	of	ADP
fnp-2615	17	10	mutated	mutate	VERB
fnp-2615	17	11	endothelial	endothelial	ADJ
fnp-2615	17	12	cells	cell	NOUN
fnp-2615	17	13	there	there	ADV
fnp-2615	17	14	have	have	AUX
fnp-2615	17	15	been	be	AUX
fnp-2615	17	16	recent	recent	ADJ
fnp-2615	17	17	advances	advance	NOUN
fnp-2615	17	18	in	in	ADP
fnp-2615	17	19	understanding	understand	VERB
fnp-2615	17	20	the	the	DET
fnp-2615	17	21	development	development	NOUN
fnp-2615	17	22	of	of	ADP
fnp-2615	17	23	cerebral	cerebral	ADJ
fnp-2615	17	24	cavernous	cavernous	ADJ
fnp-2615	17	25	angiomas	angioma	NOUN
fnp-2615	17	26	(	(	PUNCT
fnp-2615	17	27	ccm	ccm	PROPN
fnp-2615	17	28	)	)	PUNCT
fnp-2615	17	29	.	.	PUNCT
fnp-2615	18	1	new	new	ADJ
fnp-2615	18	2	results	result	NOUN
fnp-2615	18	3	suggest	suggest	VERB
fnp-2615	18	4	that	that	SCONJ
fnp-2615	18	5	small	small	ADJ
fnp-2615	18	6	angiomas	angioma	NOUN
fnp-2615	18	7	may	may	AUX
fnp-2615	18	8	derive	derive	VERB
fnp-2615	18	9	from	from	ADP
fnp-2615	18	10	a	a	DET
fnp-2615	18	11	clonal	clonal	ADJ
fnp-2615	18	12	expansion	expansion	NOUN
fnp-2615	18	13	of	of	ADP
fnp-2615	18	14	mutant	mutant	ADJ
fnp-2615	18	15	endothelial	endothelial	ADJ
fnp-2615	18	16	cells	cell	NOUN
fnp-2615	18	17	that	that	PRON
fnp-2615	18	18	undergo	undergo	VERB
fnp-2615	18	19	endothelial	endothelial	NOUN
fnp-2615	18	20	-	-	PUNCT
fnp-2615	18	21	to	to	ADP
fnp-2615	18	22	-	-	PUNCT
fnp-2615	18	23	mesenchymal	mesenchymal	NOUN
fnp-2615	18	24	transition	transition	NOUN
fnp-2615	18	25	and	and	CCONJ
fnp-2615	18	26	express	express	VERB
fnp-2615	18	27	stem	stem	NOUN
fnp-2615	18	28	-	-	PUNCT
fnp-2615	18	29	cell	cell	NOUN
fnp-2615	18	30	like	like	ADP
fnp-2615	18	31	features	feature	NOUN
fnp-2615	18	32	(	(	PUNCT
fnp-2615	18	33	fig	fig	NOUN
fnp-2615	18	34	.	.	NOUN
fnp-2615	18	35	1	1	NUM
fnp-2615	18	36	)	)	PUNCT
fnp-2615	18	37	.	.	PUNCT
fnp-2615	19	1	ccm	ccm	NOUN
fnp-2615	19	2	are	be	AUX
fnp-2615	19	3	vascular	vascular	ADJ
fnp-2615	19	4	lesions	lesion	NOUN
fnp-2615	19	5	composed	compose	VERB
fnp-2615	19	6	of	of	ADP
fnp-2615	19	7	clusters	cluster	NOUN
fnp-2615	19	8	of	of	ADP
fnp-2615	19	9	capillary	capillary	ADJ
fnp-2615	19	10	-	-	PUNCT
fnp-2615	19	11	venous	venous	ADJ
fnp-2615	19	12	blood	blood	NOUN
fnp-2615	19	13	vessels	vessel	NOUN
fnp-2615	19	14	with	with	ADP
fnp-2615	19	15	thin	thin	ADJ
fnp-2615	19	16	walls	wall	NOUN
fnp-2615	19	17	and	and	CCONJ
fnp-2615	19	18	impaired	impair	VERB
fnp-2615	19	19	endothelial	endothelial	ADJ
fnp-2615	19	20	tight	tight	ADJ
fnp-2615	19	21	junctions	junction	NOUN
fnp-2615	19	22	that	that	PRON
fnp-2615	19	23	usually	usually	ADV
fnp-2615	19	24	contain	contain	VERB
fnp-2615	19	25	stagnant	stagnant	ADJ
fnp-2615	19	26	blood	blood	NOUN
fnp-2615	19	27	.	.	PUNCT
fnp-2615	20	1	these	these	DET
fnp-2615	20	2	abnormal	abnormal	ADJ
fnp-2615	20	3	vessels	vessel	NOUN
fnp-2615	20	4	may	may	AUX
fnp-2615	20	5	rupture	rupture	VERB
fnp-2615	20	6	causing	cause	VERB
fnp-2615	20	7	intracranial	intracranial	ADJ
fnp-2615	20	8	hemorrhage	hemorrhage	NOUN
fnp-2615	20	9	(	(	PUNCT
fnp-2615	20	10	fig	fig	NOUN
fnp-2615	20	11	.	.	NOUN
fnp-2615	20	12	1	1	NUM
fnp-2615	20	13	)	)	PUNCT
fnp-2615	20	14	or	or	CCONJ
fnp-2615	20	15	small	small	ADJ
fnp-2615	20	16	subclinical	subclinical	ADJ
fnp-2615	20	17	bleeds	bleed	NOUN
fnp-2615	20	18	,	,	PUNCT
fnp-2615	20	19	which	which	PRON
fnp-2615	20	20	may	may	AUX
fnp-2615	20	21	lead	lead	VERB
fnp-2615	20	22	to	to	ADP
fnp-2615	20	23	seizures	seizure	NOUN
fnp-2615	20	24	.	.	PUNCT
fnp-2615	21	1	most	most	ADJ
fnp-2615	21	2	cases	case	NOUN
fnp-2615	21	3	of	of	ADP
fnp-2615	21	4	ccm	ccm	NOUN
fnp-2615	21	5	are	be	AUX
fnp-2615	21	6	spontaneous	spontaneous	ADJ
fnp-2615	21	7	but	but	CCONJ
fnp-2615	21	8	20	20	NUM
fnp-2615	21	9	%	%	NOUN
fnp-2615	21	10	of	of	ADP
fnp-2615	21	11	cases	case	NOUN
fnp-2615	21	12	may	may	AUX
fnp-2615	21	13	be	be	AUX
fnp-2615	21	14	attributed	attribute	VERB
fnp-2615	21	15	to	to	ADP
fnp-2615	21	16	autosomal	autosomal	ADJ
fnp-2615	21	17	dominant	dominant	ADJ
fnp-2615	21	18	inheritance	inheritance	NOUN
fnp-2615	21	19	.	.	PUNCT
fnp-2615	22	1	the	the	DET
fnp-2615	22	2	disease	disease	NOUN
fnp-2615	22	3	is	be	AUX
fnp-2615	22	4	caused	cause	VERB
fnp-2615	22	5	by	by	ADP
fnp-2615	22	6	sporadic	sporadic	ADJ
fnp-2615	22	7	or	or	CCONJ
fnp-2615	22	8	inherited	inherited	ADJ
fnp-2615	22	9	mutations	mutation	NOUN
fnp-2615	22	10	in	in	ADP
fnp-2615	22	11	one	one	NUM
fnp-2615	22	12	of	of	ADP
fnp-2615	22	13	the	the	DET
fnp-2615	22	14	following	follow	VERB
fnp-2615	22	15	three	three	NUM
fnp-2615	22	16	genes	gene	NOUN
fnp-2615	22	17	:	:	PUNCT
fnp-2615	22	18	ccm1	ccm1	PROPN
fnp-2615	22	19	(	(	PUNCT
fnp-2615	22	20	krit1	krit1	PROPN
fnp-2615	22	21	)	)	PUNCT
fnp-2615	22	22	,	,	PUNCT
fnp-2615	22	23	ccm2	ccm2	NOUN
fnp-2615	22	24	(	(	PUNCT
fnp-2615	22	25	mgc4607	mgc4607	ADJ
fnp-2615	22	26	)	)	PUNCT
fnp-2615	22	27	,	,	PUNCT
fnp-2615	22	28	or	or	CCONJ
fnp-2615	22	29	ccm3	ccm3	NOUN
fnp-2615	22	30	(	(	PUNCT
fnp-2615	22	31	pdcd10	pdcd10	PROPN
fnp-2615	22	32	)	)	PUNCT
fnp-2615	22	33	.	.	PUNCT
fnp-2615	23	1	in	in	ADP
fnp-2615	23	2	the	the	DET
fnp-2615	23	3	affected	affected	ADJ
fnp-2615	23	4	vessels	vessel	NOUN
fnp-2615	23	5	,	,	PUNCT
fnp-2615	23	6	endothelial	endothelial	ADJ
fnp-2615	23	7	cells	cell	NOUN
fnp-2615	23	8	suffer	suffer	VERB
fnp-2615	23	9	endothelial	endothelial	NOUN
fnp-2615	23	10	-	-	PUNCT
fnp-2615	23	11	to	to	ADP
fnp-2615	23	12	-	-	PUNCT
fnp-2615	23	13	mesenchymal	mesenchymal	NOUN
fnp-2615	23	14	transition	transition	NOUN
fnp-2615	23	15	(	(	PUNCT
fnp-2615	23	16	endmt	endmt	PROPN
fnp-2615	23	17	)	)	PUNCT
fnp-2615	23	18	,	,	PUNCT
fnp-2615	23	19	express	express	VERB
fnp-2615	23	20	stem	stem	NOUN
fnp-2615	23	21	cell	cell	NOUN
fnp-2615	23	22	markers	marker	NOUN
fnp-2615	23	23	,	,	PUNCT
fnp-2615	23	24	and	and	CCONJ
fnp-2615	23	25	undergo	undergo	VERB
fnp-2615	23	26	loss	loss	NOUN
fnp-2615	23	27	of	of	ADP
fnp-2615	23	28	typical	typical	ADJ
fnp-2615	23	29	endothelial	endothelial	ADJ
fnp-2615	23	30	cell	cell	NOUN
fnp-2615	23	31	properties	property	NOUN
fnp-2615	23	32	,	,	PUNCT
fnp-2615	23	33	with	with	ADP
fnp-2615	23	34	increased	increase	VERB
fnp-2615	23	35	cell	cell	NOUN
fnp-2615	23	36	migration	migration	NOUN
fnp-2615	23	37	,	,	PUNCT
fnp-2615	23	38	reduced	reduced	ADJ
fnp-2615	23	39	adherence	adherence	NOUN
fnp-2615	23	40	,	,	PUNCT
fnp-2615	23	41	and	and	CCONJ
fnp-2615	23	42	increased	increase	VERB
fnp-2615	23	43	blood	blood	NOUN
fnp-2615	23	44	-	-	PUNCT
fnp-2615	23	45	brain	brain	NOUN
fnp-2615	23	46	barrier	barrier	NOUN
fnp-2615	23	47	(	(	PUNCT
fnp-2615	23	48	bbb	bbb	NOUN
fnp-2615	23	49	)	)	PUNCT
fnp-2615	23	50	permeability	permeability	NOUN
fnp-2615	23	51	.	.	PUNCT
fnp-2615	24	1	in	in	ADP
fnp-2615	24	2	familial	familial	ADJ
fnp-2615	24	3	cases	case	NOUN
fnp-2615	24	4	,	,	PUNCT
fnp-2615	24	5	the	the	DET
fnp-2615	24	6	vascular	vascular	ADJ
fnp-2615	24	7	lesions	lesion	NOUN
fnp-2615	24	8	are	be	AUX
fnp-2615	24	9	discrete	discrete	ADJ
fnp-2615	24	10	although	although	SCONJ
fnp-2615	24	11	the	the	DET
fnp-2615	24	12	above	above	ADP
fnp-2615	24	13	genetic	genetic	ADJ
fnp-2615	24	14	mutations	mutation	NOUN
fnp-2615	24	15	affect	affect	VERB
fnp-2615	24	16	all	all	DET
fnp-2615	24	17	cells	cell	NOUN
fnp-2615	24	18	.	.	PUNCT
fnp-2615	25	1	furthermore	furthermore	ADV
fnp-2615	25	2	,	,	PUNCT
fnp-2615	25	3	heterozygous	heterozygous	ADJ
fnp-2615	25	4	mice	mouse	NOUN
fnp-2615	25	5	do	do	AUX
fnp-2615	25	6	not	not	PART
fnp-2615	25	7	develop	develop	VERB
fnp-2615	25	8	the	the	DET
fnp-2615	25	9	disease	disease	NOUN
fnp-2615	25	10	.	.	PUNCT
fnp-2615	26	1	the	the	DET
fnp-2615	26	2	prevalent	prevalent	ADJ
fnp-2615	26	3	explanation	explanation	NOUN
fnp-2615	26	4	is	be	AUX
fnp-2615	26	5	the	the	DET
fnp-2615	26	6	two	two	NUM
fnp-2615	26	7	-	-	PUNCT
fnp-2615	26	8	hit	hit	VERB
fnp-2615	26	9	hypothesis	hypothesis	NOUN
fnp-2615	26	10	.	.	PUNCT
fnp-2615	27	1	endothelial	endothelial	ADJ
fnp-2615	27	2	cells	cell	NOUN
fnp-2615	27	3	carrying	carry	VERB
fnp-2615	27	4	a	a	DET
fnp-2615	27	5	germline	germline	NOUN
fnp-2615	27	6	mutation	mutation	NOUN
fnp-2615	27	7	in	in	ADP
fnp-2615	27	8	one	one	NUM
fnp-2615	27	9	of	of	ADP
fnp-2615	27	10	the	the	DET
fnp-2615	27	11	ccm	ccm	NOUN
fnp-2615	27	12	genes	gene	NOUN
fnp-2615	27	13	need	need	VERB
fnp-2615	27	14	to	to	PART
fnp-2615	27	15	suffer	suffer	VERB
fnp-2615	27	16	a	a	DET
fnp-2615	27	17	second	second	ADJ
fnp-2615	27	18	,	,	PUNCT
fnp-2615	27	19	likely	likely	ADJ
fnp-2615	27	20	a	a	DET
fnp-2615	27	21	somatic	somatic	ADJ
fnp-2615	27	22	,	,	PUNCT
fnp-2615	27	23	mutation	mutation	NOUN
fnp-2615	27	24	that	that	PRON
fnp-2615	27	25	will	will	AUX
fnp-2615	27	26	trigger	trigger	VERB
fnp-2615	27	27	the	the	DET
fnp-2615	27	28	pathology	pathology	NOUN
fnp-2615	27	29	.	.	PUNCT
fnp-2615	28	1	malinverno	malinverno	INTJ
fnp-2615	28	2	et	et	PROPN
fnp-2615	28	3	al	al	PROPN
fnp-2615	28	4	.	.	PROPN
fnp-2615	29	1	(	(	PUNCT
fnp-2615	29	2	2019	2019	NUM
fnp-2615	29	3	)	)	PUNCT
fnp-2615	29	4	showed	show	VERB
fnp-2615	29	5	that	that	SCONJ
fnp-2615	29	6	only	only	ADV
fnp-2615	29	7	a	a	DET
fnp-2615	29	8	few	few	ADJ
fnp-2615	29	9	endothelial	endothelial	ADJ
fnp-2615	29	10	cells	cell	NOUN
fnp-2615	29	11	bearing	bear	VERB
fnp-2615	29	12	a	a	DET
fnp-2615	29	13	ccm3-/mutation	ccm3-/mutation	NOUN
fnp-2615	29	14	,	,	PUNCT
fnp-2615	29	15	undergoing	undergo	VERB
fnp-2615	29	16	endmt	endmt	ADV
fnp-2615	29	17	,	,	PUNCT
fnp-2615	29	18	and	and	CCONJ
fnp-2615	29	19	expressing	express	VERB
fnp-2615	29	20	progenitor	progenitor	NOUN
fnp-2615	29	21	markers	marker	NOUN
fnp-2615	29	22	,	,	PUNCT
fnp-2615	29	23	are	be	AUX
fnp-2615	29	24	needed	need	VERB
fnp-2615	29	25	to	to	PART
fnp-2615	29	26	generate	generate	VERB
fnp-2615	29	27	cavernomas	cavernoma	NOUN
fnp-2615	29	28	because	because	SCONJ
fnp-2615	29	29	the	the	DET
fnp-2615	29	30	affected	affect	VERB
fnp-2615	29	31	cells	cell	NOUN
fnp-2615	29	32	undergo	undergo	VERB
fnp-2615	29	33	clonal	clonal	ADJ
fnp-2615	29	34	expansion	expansion	NOUN
fnp-2615	29	35	.	.	PUNCT
fnp-2615	30	1	demonstration	demonstration	NOUN
fnp-2615	30	2	of	of	ADP
fnp-2615	30	3	clonal	clonal	ADJ
fnp-2615	30	4	expansion	expansion	NOUN
fnp-2615	30	5	was	be	AUX
fnp-2615	30	6	carried	carry	VERB
fnp-2615	30	7	out	out	ADP
fnp-2615	30	8	using	use	VERB
fnp-2615	30	9	an	an	DET
fnp-2615	30	10	elegant	elegant	ADJ
fnp-2615	30	11	strategy	strategy	NOUN
fnp-2615	30	12	by	by	ADP
fnp-2615	30	13	crossing	cross	VERB
fnp-2615	30	14	the	the	DET
fnp-2615	30	15	‘	'	PUNCT
fnp-2615	30	16	r26r	r26r	NOUN
fnp-2615	30	17	-	-	ADJ
fnp-2615	30	18	confetti	confetti	ADJ
fnp-2615	30	19	’	'	PUNCT
fnp-2615	30	20	mouse	mouse	NOUN
fnp-2615	30	21	,	,	PUNCT
fnp-2615	30	22	a	a	DET
fnp-2615	30	23	multicolor	multicolor	NOUN
fnp-2615	30	24	reporter	reporter	NOUN
fnp-2615	30	25	mouse	mouse	PROPN
fnp-2615	30	26	model	model	PROPN
fnp-2615	30	27	,	,	PUNCT
fnp-2615	30	28	first	first	ADV
fnp-2615	30	29	with	with	ADP
fnp-2615	30	30	cdh5(pac)-creert2	cdh5(pac)-creert2	NOUN
fnp-2615	30	31	mice	mice	VERB
fnp-2615	30	32	for	for	ADP
fnp-2615	30	33	an	an	DET
fnp-2615	30	34	endothelial	endothelial	ADJ
fnp-2615	30	35	specific	specific	ADJ
fnp-2615	30	36	expression	expression	NOUN
fnp-2615	30	37	of	of	ADP
fnp-2615	30	38	cre	cre	PROPN
fnp-2615	30	39	,	,	PUNCT
fnp-2615	30	40	and	and	CCONJ
fnp-2615	30	41	then	then	ADV
fnp-2615	30	42	with	with	ADP
fnp-2615	30	43	ccm3fl	ccm3fl	PROPN
fnp-2615	30	44	/	/	SYM
fnp-2615	30	45	fl	fl	NUM
fnp-2615	30	46	mice	mouse	NOUN
fnp-2615	30	47	.	.	PUNCT
fnp-2615	31	1	endothelial	endothelial	ADJ
fnp-2615	31	2	deletion	deletion	NOUN
fnp-2615	31	3	of	of	ADP
fnp-2615	31	4	ccm3	ccm3	NOUN
fnp-2615	31	5	was	be	AUX
fnp-2615	31	6	accompanied	accompany	VERB
fnp-2615	31	7	by	by	ADP
fnp-2615	31	8	color	color	NOUN
fnp-2615	31	9	-	-	PUNCT
fnp-2615	31	10	based	base	VERB
fnp-2615	31	11	clonal	clonal	ADJ
fnp-2615	31	12	lineage	lineage	NOUN
fnp-2615	31	13	tracing	trace	VERB
fnp-2615	31	14	.	.	PUNCT
fnp-2615	32	1	the	the	DET
fnp-2615	32	2	majority	majority	NOUN
fnp-2615	32	3	of	of	ADP
fnp-2615	32	4	small	small	ADJ
fnp-2615	32	5	vascular	vascular	ADJ
fnp-2615	32	6	lesions	lesion	NOUN
fnp-2615	32	7	were	be	AUX
fnp-2615	32	8	composed	compose	VERB
fnp-2615	32	9	of	of	ADP
fnp-2615	32	10	cells	cell	NOUN
fnp-2615	32	11	of	of	ADP
fnp-2615	32	12	the	the	DET
fnp-2615	32	13	same	same	ADJ
fnp-2615	32	14	color	color	NOUN
fnp-2615	32	15	suggesting	suggest	VERB
fnp-2615	32	16	a	a	DET
fnp-2615	32	17	clonal	clonal	ADJ
fnp-2615	32	18	origin	origin	NOUN
fnp-2615	32	19	from	from	ADP
fnp-2615	32	20	proliferation	proliferation	NOUN
fnp-2615	32	21	of	of	ADP
fnp-2615	32	22	the	the	DET
fnp-2615	32	23	affected	affected	ADJ
fnp-2615	32	24	endothelial	endothelial	ADJ
fnp-2615	32	25	cells	cell	NOUN
fnp-2615	32	26	.	.	PUNCT
fnp-2615	33	1	this	this	DET
fnp-2615	33	2	study	study	NOUN
fnp-2615	33	3	followed	follow	VERB
fnp-2615	33	4	two	two	NUM
fnp-2615	33	5	previous	previous	ADJ
fnp-2615	33	6	studies	study	NOUN
fnp-2615	33	7	(	(	PUNCT
fnp-2615	33	8	detter	detter	NOUN
fnp-2615	33	9	et	et	PROPN
fnp-2615	33	10	al	al	PROPN
fnp-2615	33	11	.	.	PROPN
fnp-2615	33	12	,	,	PUNCT
fnp-2615	33	13	2018	2018	NUM
fnp-2615	33	14	;	;	PUNCT
fnp-2615	33	15	manavski	manavski	NOUN
fnp-2615	33	16	et	et	PROPN
fnp-2615	33	17	al	al	PROPN
fnp-2615	33	18	.	.	PROPN
fnp-2615	33	19	,	,	PUNCT
fnp-2615	33	20	2018	2018	NUM
fnp-2615	33	21	)	)	PUNCT
fnp-2615	33	22	where	where	SCONJ
fnp-2615	33	23	clonal	clonal	ADJ
fnp-2615	33	24	expansion	expansion	NOUN
fnp-2615	33	25	of	of	ADP
fnp-2615	33	26	mutant	mutant	ADJ
fnp-2615	33	27	endothelial	endothelial	ADJ
fnp-2615	33	28	cell	cell	NOUN
fnp-2615	33	29	in	in	ADP
fnp-2615	33	30	ccm	ccm	PROPN
fnp-2615	33	31	endmt	endmt	PROPN
fnp-2615	33	32	was	be	AUX
fnp-2615	33	33	also	also	ADV
fnp-2615	33	34	demonstrated	demonstrate	VERB
fnp-2615	33	35	using	use	VERB
fnp-2615	33	36	a	a	DET
fnp-2615	33	37	reporter	reporter	NOUN
fnp-2615	33	38	confetti	confetti	NOUN
fnp-2615	33	39	strategy	strategy	NOUN
fnp-2615	33	40	.	.	PUNCT
fnp-2615	34	1	in	in	ADP
fnp-2615	34	2	contrast	contrast	NOUN
fnp-2615	34	3	to	to	ADP
fnp-2615	34	4	the	the	DET
fnp-2615	34	5	clonal	clonal	ADJ
fnp-2615	34	6	origin	origin	NOUN
fnp-2615	34	7	of	of	ADP
fnp-2615	34	8	small	small	ADJ
fnp-2615	34	9	lesions	lesion	NOUN
fnp-2615	34	10	,	,	PUNCT
fnp-2615	34	11	large	large	ADJ
fnp-2615	34	12	cavernomas	cavernoma	NOUN
fnp-2615	34	13	are	be	AUX
fnp-2615	34	14	mosaics	mosaic	NOUN
fnp-2615	34	15	containing	contain	VERB
fnp-2615	34	16	clonally	clonally	ADV
fnp-2615	34	17	dominant	dominant	ADJ
fnp-2615	34	18	mutant	mutant	ADJ
fnp-2615	34	19	cells	cell	NOUN
fnp-2615	34	20	and	and	CCONJ
fnp-2615	34	21	wild	wild	ADJ
fnp-2615	34	22	type	type	NOUN
fnp-2615	34	23	endothelial	endothelial	NOUN
fnp-2615	34	24	cells	cell	NOUN
fnp-2615	34	25	suggesting	suggest	VERB
fnp-2615	34	26	recruitment	recruitment	NOUN
fnp-2615	34	27	of	of	ADP
fnp-2615	34	28	neighboring	neighbor	VERB
fnp-2615	34	29	wild	wild	ADJ
fnp-2615	34	30	type	type	NOUN
fnp-2615	34	31	cells	cell	NOUN
fnp-2615	34	32	to	to	ADP
fnp-2615	34	33	the	the	DET
fnp-2615	34	34	cavernous	cavernous	ADJ
fnp-2615	34	35	lesion	lesion	NOUN
fnp-2615	34	36	.	.	PUNCT
fnp-2615	35	1	those	those	DET
fnp-2615	35	2	wild	wild	ADJ
fnp-2615	35	3	type	type	NOUN
fnp-2615	35	4	endothelial	endothelial	NOUN
fnp-2615	35	5	cells	cell	NOUN
fnp-2615	35	6	also	also	ADV
fnp-2615	35	7	overexpressed	overexpresse	VERB
fnp-2615	35	8	endmt	endmt	PROPN
fnp-2615	35	9	markers	marker	NOUN
fnp-2615	35	10	.	.	PUNCT
fnp-2615	36	1	transplantation	transplantation	NOUN
fnp-2615	36	2	of	of	ADP
fnp-2615	36	3	ccm3-/cells	ccm3-/cell	NOUN
fnp-2615	36	4	into	into	ADP
fnp-2615	36	5	the	the	DET
fnp-2615	36	6	brain	brain	NOUN
fnp-2615	36	7	of	of	ADP
fnp-2615	36	8	wild	wild	ADJ
fnp-2615	36	9	type	type	NOUN
fnp-2615	36	10	mice	mouse	NOUN
fnp-2615	36	11	generated	generate	VERB
fnp-2615	36	12	abnormal	abnormal	ADJ
fnp-2615	36	13	vessels	vessel	NOUN
fnp-2615	36	14	and	and	CCONJ
fnp-2615	36	15	recruited	recruit	VERB
fnp-2615	36	16	endothelial	endothelial	ADJ
fnp-2615	36	17	cells	cell	NOUN
fnp-2615	36	18	from	from	ADP
fnp-2615	36	19	the	the	DET
fnp-2615	36	20	host	host	NOUN
fnp-2615	36	21	(	(	PUNCT
fnp-2615	36	22	malinverno	malinverno	NOUN
fnp-2615	36	23	et	et	PROPN
fnp-2615	36	24	al	al	PROPN
fnp-2615	36	25	.	.	PROPN
fnp-2615	36	26	,	,	PUNCT
fnp-2615	36	27	2019	2019	NUM
fnp-2615	36	28	)	)	PUNCT
fnp-2615	36	29	.	.	PUNCT
fnp-2615	37	1	by	by	ADP
fnp-2615	37	2	means	mean	NOUN
fnp-2615	37	3	of	of	ADP
fnp-2615	37	4	several	several	ADJ
fnp-2615	37	5	in	in	ADP
fnp-2615	37	6	vitro	vitro	X
fnp-2615	37	7	studies	study	NOUN
fnp-2615	37	8	,	,	PUNCT
fnp-2615	37	9	these	these	DET
fnp-2615	37	10	authors	author	NOUN
fnp-2615	37	11	demonstrated	demonstrate	VERB
fnp-2615	37	12	that	that	SCONJ
fnp-2615	37	13	wild	wild	ADJ
fnp-2615	37	14	type	type	NOUN
fnp-2615	37	15	endothelial	endothelial	NOUN
fnp-2615	37	16	cells	cell	NOUN
fnp-2615	37	17	acquire	acquire	VERB
fnp-2615	37	18	features	feature	NOUN
fnp-2615	37	19	of	of	ADP
fnp-2615	37	20	endmt	endmt	PROPN
fnp-2615	37	21	after	after	ADP
fnp-2615	37	22	contacting	contact	VERB
fnp-2615	37	23	ccm3-/cells	ccm3-/cell	NOUN
fnp-2615	37	24	.	.	PUNCT
fnp-2615	38	1	furthermore	furthermore	ADV
fnp-2615	38	2	,	,	PUNCT
fnp-2615	38	3	by	by	ADP
fnp-2615	38	4	using	use	VERB
fnp-2615	38	5	genetic	genetic	ADJ
fnp-2615	38	6	mouse	mouse	NOUN
fnp-2615	38	7	models	model	NOUN
fnp-2615	38	8	,	,	PUNCT
fnp-2615	38	9	malinverno	malinverno	NOUN
fnp-2615	38	10	et	et	PROPN
fnp-2615	38	11	al	al	PROPN
fnp-2615	38	12	.	.	PROPN
fnp-2615	38	13	deleted	delete	VERB
fnp-2615	38	14	ccm3	ccm3	NOUN
fnp-2615	38	15	in	in	ADP
fnp-2615	38	16	endothelial	endothelial	ADJ
fnp-2615	38	17	progenitors	progenitor	NOUN
fnp-2615	38	18	.	.	PUNCT
fnp-2615	39	1	they	they	PRON
fnp-2615	39	2	hypothesized	hypothesize	VERB
fnp-2615	39	3	that	that	SCONJ
fnp-2615	39	4	the	the	DET
fnp-2615	39	5	early	early	ADJ
fnp-2615	39	6	steps	step	NOUN
fnp-2615	39	7	of	of	ADP
fnp-2615	39	8	cavernoma	cavernoma	NOUN
fnp-2615	39	9	formation	formation	NOUN
fnp-2615	39	10	are	be	AUX
fnp-2615	39	11	due	due	ADJ
fnp-2615	39	12	to	to	ADP
fnp-2615	39	13	clonal	clonal	ADJ
fnp-2615	39	14	expansion	expansion	NOUN
fnp-2615	39	15	of	of	ADP
fnp-2615	39	16	resident	resident	ADJ
fnp-2615	39	17	endothelial	endothelial	ADJ
fnp-2615	39	18	progenitors	progenitor	NOUN
fnp-2615	39	19	.	.	PUNCT
fnp-2615	40	1	in	in	ADP
fnp-2615	40	2	this	this	DET
fnp-2615	40	3	way	way	NOUN
fnp-2615	40	4	they	they	PRON
fnp-2615	40	5	provided	provide	VERB
fnp-2615	40	6	evidence	evidence	NOUN
fnp-2615	40	7	supporting	support	VERB
fnp-2615	40	8	the	the	DET
fnp-2615	40	9	view	view	NOUN
fnp-2615	40	10	that	that	SCONJ
fnp-2615	40	11	endothelial	endothelial	ADJ
fnp-2615	40	12	progenitors	progenitor	NOUN
fnp-2615	40	13	suffering	suffer	VERB
fnp-2615	40	14	ccm3	ccm3	ADJ
fnp-2615	40	15	mutation	mutation	NOUN
fnp-2615	40	16	trigger	trigger	NOUN
fnp-2615	40	17	cavernoma	cavernoma	NOUN
fnp-2615	40	18	formation	formation	NOUN
fnp-2615	40	19	.	.	PUNCT
fnp-2615	41	1	hopefully	hopefully	ADV
fnp-2615	41	2	these	these	DET
fnp-2615	41	3	new	new	ADJ
fnp-2615	41	4	discoveries	discovery	NOUN
fnp-2615	41	5	will	will	AUX
fnp-2615	41	6	provide	provide	VERB
fnp-2615	41	7	novel	novel	ADJ
fnp-2615	41	8	avenues	avenue	NOUN
fnp-2615	41	9	to	to	PART
fnp-2615	41	10	prevent	prevent	VERB
fnp-2615	41	11	or	or	CCONJ
fnp-2615	41	12	attenuate	attenuate	VERB
fnp-2615	41	13	ccm	ccm	PROPN
fnp-2615	41	14	.	.	PROPN
fnp-2615	41	15	figure	figure	NOUN
fnp-2615	41	16	1	1	NUM
fnp-2615	41	17	.	.	PUNCT
fnp-2615	41	18	cavernomas	cavernoma	NOUN
fnp-2615	41	19	.	.	PUNCT
fnp-2615	42	1	schematic	schematic	ADJ
fnp-2615	42	2	representation	representation	NOUN
fnp-2615	42	3	of	of	ADP
fnp-2615	42	4	cavernoma	cavernoma	NOUN
fnp-2615	42	5	generation	generation	NOUN
fnp-2615	42	6	from	from	ADP
fnp-2615	42	7	vessels	vessel	NOUN
fnp-2615	42	8	with	with	ADP
fnp-2615	42	9	mutated	mutate	VERB
fnp-2615	42	10	ccm	ccm	NOUN
fnp-2615	42	11	genes	gene	NOUN
fnp-2615	42	12	(	(	PUNCT
fnp-2615	42	13	see	see	VERB
fnp-2615	42	14	text	text	NOUN
fnp-2615	42	15	section	section	NOUN
fnp-2615	42	16	1	1	NUM
fnp-2615	42	17	)	)	PUNCT
fnp-2615	42	18	.	.	PUNCT
fnp-2615	43	1	according	accord	VERB
fnp-2615	43	2	to	to	ADP
fnp-2615	43	3	malinverno	malinverno	NOUN
fnp-2615	43	4	et	et	PROPN
fnp-2615	43	5	al	al	PROPN
fnp-2615	43	6	.	.	PROPN
fnp-2615	43	7	,	,	PUNCT
fnp-2615	43	8	(	(	PUNCT
fnp-2615	43	9	2019	2019	NUM
fnp-2615	43	10	)	)	PUNCT
fnp-2615	43	11	,	,	PUNCT
fnp-2615	43	12	the	the	DET
fnp-2615	43	13	process	process	NOUN
fnp-2615	43	14	involves	involve	VERB
fnp-2615	43	15	endothelial	endothelial	NOUN
fnp-2615	43	16	-	-	PUNCT
fnp-2615	43	17	to	to	ADP
fnp-2615	43	18	-	-	PUNCT
fnp-2615	43	19	mesenchymal	mesenchymal	NOUN
fnp-2615	43	20	transition	transition	NOUN
fnp-2615	43	21	(	(	PUNCT
fnp-2615	43	22	endmt	endmt	PROPN
fnp-2615	43	23	)	)	PUNCT
fnp-2615	43	24	and	and	CCONJ
fnp-2615	43	25	clonal	clonal	ADJ
fnp-2615	43	26	expansion	expansion	NOUN
fnp-2615	43	27	.	.	PUNCT
fnp-2615	44	1	susceptibility	susceptibility	NOUN
fnp-2615	44	2	weighted	weight	VERB
fnp-2615	44	3	imaging	imaging	NOUN
fnp-2615	44	4	shows	show	VERB
fnp-2615	44	5	a	a	DET
fnp-2615	44	6	cavernoma	cavernoma	NOUN
fnp-2615	44	7	with	with	ADP
fnp-2615	44	8	hemorrhage	hemorrhage	NOUN
fnp-2615	44	9	in	in	ADP
fnp-2615	44	10	the	the	DET
fnp-2615	44	11	right	right	ADJ
fnp-2615	44	12	occipital	occipital	NOUN
fnp-2615	44	13	lobe	lobe	NOUN
fnp-2615	44	14	(	(	PUNCT
fnp-2615	44	15	arrow	arrow	NOUN
fnp-2615	44	16	)	)	PUNCT
fnp-2615	44	17	.	.	PUNCT
fnp-2615	45	1	the	the	DET
fnp-2615	45	2	mri	mri	NOUN
fnp-2615	45	3	image	image	NOUN
fnp-2615	45	4	was	be	AUX
fnp-2615	45	5	obtained	obtain	VERB
fnp-2615	45	6	in	in	ADP
fnp-2615	45	7	the	the	DET
fnp-2615	45	8	comprehensive	comprehensive	ADJ
fnp-2615	45	9	stroke	stroke	NOUN
fnp-2615	45	10	center	center	PROPN
fnp-2615	45	11	of	of	ADP
fnp-2615	45	12	hospital	hospital	NOUN
fnp-2615	45	13	clinic	clinic	PROPN
fnp-2615	45	14	of	of	ADP
fnp-2615	45	15	barcelona	barcelona	PROPN
fnp-2615	45	16	.	.	PUNCT
fnp-2615	46	1	2	2	NUM
fnp-2615	46	2	.	.	X
fnp-2615	46	3	cerebral	cerebral	ADJ
fnp-2615	46	4	arteriovenous	arteriovenous	ADJ
fnp-2615	46	5	malformations	malformation	NOUN
fnp-2615	46	6	:	:	PUNCT
fnp-2615	46	7	from	from	ADP
fnp-2615	46	8	origin	origin	NOUN
fnp-2615	46	9	to	to	ADP
fnp-2615	46	10	treatment	treatment	NOUN
fnp-2615	46	11	failure	failure	NOUN
fnp-2615	46	12	to	to	PART
fnp-2615	46	13	achieve	achieve	VERB
fnp-2615	46	14	full	full	ADJ
fnp-2615	46	15	endothelial	endothelial	ADJ
fnp-2615	46	16	cell	cell	NOUN
fnp-2615	46	17	differentiation	differentiation	NOUN
fnp-2615	46	18	could	could	AUX
fnp-2615	46	19	underlie	underlie	VERB
fnp-2615	46	20	the	the	DET
fnp-2615	46	21	pathology	pathology	NOUN
fnp-2615	46	22	of	of	ADP
fnp-2615	46	23	arteriovenous	arteriovenous	ADJ
fnp-2615	46	24	malformations	malformation	NOUN
fnp-2615	46	25	(	(	PUNCT
fnp-2615	46	26	avms	avms	NOUN
fnp-2615	46	27	)	)	PUNCT
fnp-2615	46	28	where	where	SCONJ
fnp-2615	46	29	recent	recent	ADJ
fnp-2615	46	30	studies	study	NOUN
fnp-2615	46	31	identified	identify	VERB
fnp-2615	46	32	β	β	NOUN
fnp-2615	46	33	-	-	ADJ
fnp-2615	46	34	adrenergic	adrenergic	ADJ
fnp-2615	46	35	antagonists	antagonist	NOUN
fnp-2615	46	36	as	as	ADP
fnp-2615	46	37	putative	putative	ADJ
fnp-2615	46	38	curative	curative	ADJ
fnp-2615	46	39	treatments	treatment	NOUN
fnp-2615	46	40	.	.	PUNCT
fnp-2615	47	1	avms	avms	PROPN
fnp-2615	47	2	involve	involve	VERB
fnp-2615	47	3	the	the	DET
fnp-2615	47	4	formation	formation	NOUN
fnp-2615	47	5	of	of	ADP
fnp-2615	47	6	arteriovenous	arteriovenous	ADJ
fnp-2615	47	7	shunts	shunt	NOUN
fnp-2615	47	8	amongst	amongst	ADP
fnp-2615	47	9	other	other	ADJ
fnp-2615	47	10	vascular	vascular	ADJ
fnp-2615	47	11	abnormalities	abnormality	NOUN
fnp-2615	47	12	including	include	VERB
fnp-2615	47	13	vessel	vessel	NOUN
fnp-2615	47	14	calcifications	calcification	NOUN
fnp-2615	47	15	,	,	PUNCT
fnp-2615	47	16	and	and	CCONJ
fnp-2615	47	17	the	the	DET
fnp-2615	47	18	presence	presence	NOUN
fnp-2615	47	19	of	of	ADP
fnp-2615	47	20	surrounding	surround	VERB
fnp-2615	47	21	macrophages	macrophage	NOUN
fnp-2615	47	22	and	and	CCONJ
fnp-2615	47	23	gliosis	gliosis	NOUN
fnp-2615	47	24	.	.	PUNCT
fnp-2615	48	1	this	this	DET
fnp-2615	48	2	condition	condition	NOUN
fnp-2615	48	3	impairs	impair	VERB
fnp-2615	48	4	oxygen	oxygen	NOUN
fnp-2615	48	5	delivery	delivery	NOUN
fnp-2615	48	6	to	to	ADP
fnp-2615	48	7	the	the	DET
fnp-2615	48	8	parenchyma	parenchyma	NOUN
fnp-2615	48	9	and	and	CCONJ
fnp-2615	48	10	predisposes	predispose	NOUN
fnp-2615	48	11	to	to	ADP
fnp-2615	48	12	vessel	vessel	NOUN
fnp-2615	48	13	rupture	rupture	NOUN
fnp-2615	48	14	and	and	CCONJ
fnp-2615	48	15	hemorrhage	hemorrhage	NOUN
fnp-2615	48	16	.	.	PUNCT
fnp-2615	49	1	alterations	alteration	NOUN
fnp-2615	49	2	in	in	ADP
fnp-2615	49	3	endothelial	endothelial	ADJ
fnp-2615	49	4	cell	cell	NOUN
fnp-2615	49	5	endmt	endmt	NOUN
fnp-2615	49	6	are	be	AUX
fnp-2615	49	7	associated	associate	VERB
fnp-2615	49	8	with	with	ADP
fnp-2615	49	9	this	this	DET
fnp-2615	49	10	pathology	pathology	NOUN
fnp-2615	49	11	.	.	PUNCT
fnp-2615	50	1	yao	yao	PROPN
fnp-2615	50	2	et	et	PROPN
fnp-2615	50	3	al	al	PROPN
fnp-2615	50	4	.	.	PROPN
fnp-2615	51	1	(	(	PUNCT
fnp-2615	51	2	2019	2019	NUM
fnp-2615	51	3	)	)	PUNCT
fnp-2615	51	4	recently	recently	ADV
fnp-2615	51	5	investigated	investigate	VERB
fnp-2615	51	6	the	the	DET
fnp-2615	51	7	presence	presence	NOUN
fnp-2615	51	8	of	of	ADP
fnp-2615	51	9	endmt	endmt	PROPN
fnp-2615	51	10	markers	marker	NOUN
fnp-2615	51	11	in	in	ADP
fnp-2615	51	12	the	the	DET
fnp-2615	51	13	endothelium	endothelium	NOUN
fnp-2615	51	14	of	of	ADP
fnp-2615	51	15	human	human	ADJ
fnp-2615	51	16	avms	avms	PROPN
fnp-2615	51	17	.	.	PUNCT
fnp-2615	52	1	through	through	ADP
fnp-2615	52	2	complementary	complementary	ADJ
fnp-2615	52	3	strategies	strategy	NOUN
fnp-2615	52	4	they	they	PRON
fnp-2615	52	5	identified	identify	VERB
fnp-2615	52	6	the	the	DET
fnp-2615	52	7	expression	expression	NOUN
fnp-2615	52	8	of	of	ADP
fnp-2615	52	9	the	the	DET
fnp-2615	52	10	stem	stem	NOUN
fnp-2615	52	11	cell	cell	NOUN
fnp-2615	52	12	marker	marker	NOUN
fnp-2615	52	13	sry	sry	PROPN
fnp-2615	52	14	-	-	NOUN
fnp-2615	52	15	box	box	PROPN
fnp-2615	52	16	2	2	NUM
fnp-2615	52	17	(	(	PUNCT
fnp-2615	52	18	sox2	sox2	NOUN
fnp-2615	52	19	)	)	PUNCT
fnp-2615	52	20	and	and	CCONJ
fnp-2615	52	21	the	the	DET
fnp-2615	52	22	mesenchymal	mesenchymal	NOUN
fnp-2615	52	23	marker	marker	NOUN
fnp-2615	52	24	n	n	CCONJ
fnp-2615	52	25	-	-	PUNCT
fnp-2615	52	26	cadherin	cadherin	NOUN
fnp-2615	52	27	in	in	ADP
fnp-2615	52	28	lesional	lesional	ADJ
fnp-2615	52	29	endothelial	endothelial	ADJ
fnp-2615	52	30	cells	cell	NOUN
fnp-2615	52	31	,	,	PUNCT
fnp-2615	52	32	together	together	ADV
fnp-2615	52	33	with	with	ADP
fnp-2615	52	34	a	a	DET
fnp-2615	52	35	reduction	reduction	NOUN
fnp-2615	52	36	in	in	ADP
fnp-2615	52	37	the	the	DET
fnp-2615	52	38	expression	expression	NOUN
fnp-2615	52	39	of	of	ADP
fnp-2615	52	40	typical	typical	ADJ
fnp-2615	52	41	endothelial	endothelial	ADJ
fnp-2615	52	42	markers	marker	NOUN
fnp-2615	52	43	.	.	PUNCT
fnp-2615	53	1	the	the	DET
fnp-2615	53	2	authors	author	NOUN
fnp-2615	53	3	also	also	ADV
fnp-2615	53	4	investigated	investigate	VERB
fnp-2615	53	5	a	a	DET
fnp-2615	53	6	mouse	mouse	NOUN
fnp-2615	53	7	model	model	NOUN
fnp-2615	53	8	of	of	ADP
fnp-2615	53	9	avms	avms	NOUN
fnp-2615	53	10	,	,	PUNCT
fnp-2615	53	11	the	the	DET
fnp-2615	53	12	matrix	matrix	NOUN
fnp-2615	53	13	gla	gla	PROPN
fnp-2615	53	14	protein	protein	NOUN
fnp-2615	53	15	null	null	NOUN
fnp-2615	53	16	(	(	PUNCT
fnp-2615	53	17	mgp-/-	mgp-/-	NOUN
fnp-2615	53	18	)	)	PUNCT
fnp-2615	53	19	mouse	mouse	NOUN
fnp-2615	53	20	,	,	PUNCT
fnp-2615	53	21	which	which	PRON
fnp-2615	53	22	develops	develop	VERB
fnp-2615	53	23	arterial	arterial	ADJ
fnp-2615	53	24	calcifications	calcification	NOUN
fnp-2615	53	25	,	,	PUNCT
fnp-2615	53	26	enlarged	enlarged	ADJ
fnp-2615	53	27	vessels	vessel	NOUN
fnp-2615	53	28	,	,	PUNCT
fnp-2615	53	29	and	and	CCONJ
fnp-2615	53	30	arterial	arterial	ADJ
fnp-2615	53	31	-	-	PUNCT
fnp-2615	53	32	venous	venous	ADJ
fnp-2615	53	33	shunts	shunt	NOUN
fnp-2615	53	34	.	.	PUNCT
fnp-2615	54	1	cerebral	cerebral	ADJ
fnp-2615	54	2	endothelial	endothelial	ADJ
fnp-2615	54	3	cells	cell	NOUN
fnp-2615	54	4	of	of	ADP
fnp-2615	54	5	these	these	DET
fnp-2615	54	6	mice	mouse	NOUN
fnp-2615	54	7	also	also	ADV
fnp-2615	54	8	overexpressed	overexpresse	VERB
fnp-2615	54	9	sox2.they	sox2.they	PRON
fnp-2615	54	10	limited	limit	VERB
fnp-2615	54	11	sox2	sox2	NOUN
fnp-2615	54	12	expression	expression	NOUN
fnp-2615	54	13	in	in	ADP
fnp-2615	54	14	endothelial	endothelial	ADJ
fnp-2615	54	15	cells	cell	NOUN
fnp-2615	54	16	by	by	ADP
fnp-2615	54	17	generating	generate	VERB
fnp-2615	54	18	heterozygous	heterozygous	ADJ
fnp-2615	54	19	cdh5	cdh5	PROPN
fnp-2615	54	20	-	-	PUNCT
fnp-2615	54	21	cre	cre	PROPN
fnp-2615	54	22	/	/	SYM
fnp-2615	54	23	sox2fl	sox2fl	NOUN
fnp-2615	54	24	/	/	SYM
fnp-2615	54	25	wt	wt	NOUN
fnp-2615	54	26	mice	mouse	NOUN
fnp-2615	54	27	with	with	ADP
fnp-2615	54	28	endothelial	endothelial	ADJ
fnp-2615	54	29	deletion	deletion	NOUN
fnp-2615	54	30	of	of	ADP
fnp-2615	54	31	sox2	sox2	NOUN
fnp-2615	54	32	in	in	ADP
fnp-2615	54	33	heterozygosis	heterozygosis	NOUN
fnp-2615	54	34	.	.	PUNCT
fnp-2615	55	1	these	these	DET
fnp-2615	55	2	mice	mouse	NOUN
fnp-2615	55	3	were	be	AUX
fnp-2615	55	4	bred	breed	VERB
fnp-2615	55	5	with	with	ADP
fnp-2615	55	6	mgp-/mice	mgp-/mice	PROPN
fnp-2615	55	7	,	,	PUNCT
fnp-2615	55	8	which	which	PRON
fnp-2615	55	9	no	no	ADV
fnp-2615	55	10	longer	long	ADV
fnp-2615	55	11	overexpressed	overexpresse	VERB
fnp-2615	55	12	sox2	sox2	NOUN
fnp-2615	55	13	and	and	CCONJ
fnp-2615	55	14	,	,	PUNCT
fnp-2615	55	15	importantly	importantly	ADV
fnp-2615	55	16	,	,	PUNCT
fnp-2615	55	17	the	the	DET
fnp-2615	55	18	pathological	pathological	ADJ
fnp-2615	55	19	vascular	vascular	ADJ
fnp-2615	55	20	features	feature	NOUN
fnp-2615	55	21	of	of	ADP
fnp-2615	55	22	avms	avms	NOUN
fnp-2615	55	23	were	be	AUX
fnp-2615	55	24	strongly	strongly	ADV
fnp-2615	55	25	attenuated	attenuate	VERB
fnp-2615	55	26	.	.	PUNCT
fnp-2615	56	1	moreover	moreover	ADV
fnp-2615	56	2	,	,	PUNCT
fnp-2615	56	3	reduction	reduction	NOUN
fnp-2615	56	4	of	of	ADP
fnp-2615	56	5	sox2	sox2	NOUN
fnp-2615	56	6	abolished	abolish	VERB
fnp-2615	56	7	the	the	DET
fnp-2615	56	8	expression	expression	NOUN
fnp-2615	56	9	of	of	ADP
fnp-2615	56	10	endmt	endmt	PROPN
fnp-2615	56	11	markers	marker	NOUN
fnp-2615	56	12	.	.	PUNCT
fnp-2615	57	1	chip	chip	NOUN
fnp-2615	57	2	-	-	PUNCT
fnp-2615	57	3	seq	seq	NOUN
fnp-2615	57	4	analysis	analysis	NOUN
fnp-2615	57	5	showed	show	VERB
fnp-2615	57	6	alterations	alteration	NOUN
fnp-2615	57	7	in	in	ADP
fnp-2615	57	8	histone	histone	NOUN
fnp-2615	57	9	methylation	methylation	NOUN
fnp-2615	57	10	affecting	affect	VERB
fnp-2615	57	11	the	the	DET
fnp-2615	57	12	expression	expression	NOUN
fnp-2615	57	13	of	of	ADP
fnp-2615	57	14	several	several	ADJ
fnp-2615	57	15	genes	gene	NOUN
fnp-2615	57	16	that	that	PRON
fnp-2615	57	17	participate	participate	VERB
fnp-2615	57	18	in	in	ADP
fnp-2615	57	19	stem	stem	NOUN
fnp-2615	57	20	cell	cell	NOUN
fnp-2615	57	21	pathways	pathway	NOUN
fnp-2615	57	22	and	and	CCONJ
fnp-2615	57	23	epithelial	epithelial	ADJ
fnp-2615	57	24	-	-	PUNCT
fnp-2615	57	25	mesenchymal	mesenchymal	ADJ
fnp-2615	57	26	signaling	signaling	NOUN
fnp-2615	57	27	.	.	PUNCT
fnp-2615	58	1	the	the	DET
fnp-2615	58	2	analysis	analysis	NOUN
fnp-2615	58	3	identified	identify	VERB
fnp-2615	58	4	overexpression	overexpression	NOUN
fnp-2615	58	5	of	of	ADP
fnp-2615	58	6	the	the	DET
fnp-2615	58	7	gene	gene	NOUN
fnp-2615	58	8	jmjd5	jmjd5	PROPN
fnp-2615	58	9	in	in	ADP
fnp-2615	58	10	mgp-/cerebral	mgp-/cerebral	ADJ
fnp-2615	58	11	endothelial	endothelial	ADJ
fnp-2615	58	12	cells	cell	NOUN
fnp-2615	58	13	as	as	ADP
fnp-2615	58	14	a	a	DET
fnp-2615	58	15	downstream	downstream	ADJ
fnp-2615	58	16	target	target	NOUN
fnp-2615	58	17	of	of	ADP
fnp-2615	58	18	sox2	sox2	NOUN
fnp-2615	58	19	.	.	PUNCT
fnp-2615	59	1	then	then	ADV
fnp-2615	59	2	,	,	PUNCT
fnp-2615	59	3	a	a	DET
fnp-2615	59	4	human	human	ADJ
fnp-2615	59	5	brain	brain	NOUN
fnp-2615	59	6	microvascular	microvascular	NOUN
fnp-2615	59	7	endothelial	endothelial	ADJ
fnp-2615	59	8	cell	cell	NOUN
fnp-2615	59	9	line	line	NOUN
fnp-2615	59	10	depleted	deplete	VERB
fnp-2615	59	11	of	of	ADP
fnp-2615	59	12	mgp	mgp	PROPN
fnp-2615	59	13	was	be	AUX
fnp-2615	59	14	generated	generate	VERB
fnp-2615	59	15	using	use	VERB
fnp-2615	59	16	crisp	crisp	ADJ
fnp-2615	59	17	/	/	SYM
fnp-2615	59	18	cas9	cas9	NOUN
fnp-2615	59	19	technology	technology	NOUN
fnp-2615	59	20	.	.	PUNCT
fnp-2615	60	1	this	this	DET
fnp-2615	60	2	line	line	NOUN
fnp-2615	60	3	showed	show	VERB
fnp-2615	60	4	higher	high	ADJ
fnp-2615	60	5	expression	expression	NOUN
fnp-2615	60	6	of	of	ADP
fnp-2615	60	7	n	n	CCONJ
fnp-2615	60	8	-	-	PUNCT
fnp-2615	60	9	cadherin	cadherin	NOUN
fnp-2615	60	10	than	than	ADP
fnp-2615	60	11	wild	wild	ADJ
fnp-2615	60	12	type	type	NOUN
fnp-2615	60	13	cells	cell	NOUN
fnp-2615	60	14	,	,	PUNCT
fnp-2615	60	15	suggesting	suggest	VERB
fnp-2615	60	16	endmt	endmt	PROPN
fnp-2615	60	17	.	.	PUNCT
fnp-2615	61	1	in	in	ADP
fnp-2615	61	2	addition	addition	NOUN
fnp-2615	61	3	,	,	PUNCT
fnp-2615	61	4	these	these	DET
fnp-2615	61	5	cells	cell	NOUN
fnp-2615	61	6	overexpressed	overexpresse	VERB
fnp-2615	61	7	sox2	sox2	NOUN
fnp-2615	61	8	and	and	CCONJ
fnp-2615	61	9	jmjd5	jmjd5	PROPN
fnp-2615	61	10	.	.	PUNCT
fnp-2615	62	1	sox2	sox2	NOUN
fnp-2615	62	2	depletion	depletion	NOUN
fnp-2615	62	3	reduced	reduce	VERB
fnp-2615	62	4	jmjd5	jmjd5	PROPN
fnp-2615	62	5	expression	expression	NOUN
fnp-2615	62	6	.	.	PUNCT
fnp-2615	63	1	further	further	ADJ
fnp-2615	63	2	experiments	experiment	NOUN
fnp-2615	63	3	suggested	suggest	VERB
fnp-2615	63	4	that	that	SCONJ
fnp-2615	63	5	sox2	sox2	NOUN
fnp-2615	63	6	also	also	ADV
fnp-2615	63	7	interacts	interact	VERB
fnp-2615	63	8	with	with	ADP
fnp-2615	63	9	jmjd5	jmjd5	PROPN
fnp-2615	63	10	to	to	PART
fnp-2615	63	11	regulate	regulate	VERB
fnp-2615	63	12	endmt	endmt	ADV
fnp-2615	63	13	.	.	PUNCT
fnp-2615	64	1	to	to	PART
fnp-2615	64	2	identify	identify	VERB
fnp-2615	64	3	drugs	drug	NOUN
fnp-2615	64	4	that	that	PRON
fnp-2615	64	5	could	could	AUX
fnp-2615	64	6	prevent	prevent	VERB
fnp-2615	64	7	avms	avms	NOUN
fnp-2615	64	8	by	by	ADP
fnp-2615	64	9	inhibiting	inhibit	VERB
fnp-2615	64	10	sox2	sox2	NOUN
fnp-2615	64	11	,	,	PUNCT
fnp-2615	64	12	a	a	DET
fnp-2615	64	13	high	high	ADJ
fnp-2615	64	14	-	-	PUNCT
fnp-2615	64	15	throughput	throughput	NOUN
fnp-2615	64	16	robotic	robotic	ADJ
fnp-2615	64	17	model	model	NOUN
fnp-2615	64	18	was	be	AUX
fnp-2615	64	19	generated	generate	VERB
fnp-2615	64	20	using	use	VERB
fnp-2615	64	21	a	a	DET
fnp-2615	64	22	cell	cell	NOUN
fnp-2615	64	23	line	line	NOUN
fnp-2615	64	24	that	that	PRON
fnp-2615	64	25	allowed	allow	VERB
fnp-2615	64	26	screening	screening	NOUN
fnp-2615	64	27	of	of	ADP
fnp-2615	64	28	more	more	ADJ
fnp-2615	64	29	than	than	ADP
fnp-2615	64	30	3,000	3,000	NUM
fnp-2615	64	31	products	product	NOUN
fnp-2615	64	32	.	.	PUNCT
fnp-2615	65	1	the	the	DET
fnp-2615	65	2	system	system	NOUN
fnp-2615	65	3	identified	identify	VERB
fnp-2615	65	4	a	a	DET
fnp-2615	65	5	drug	drug	NOUN
fnp-2615	65	6	called	call	VERB
fnp-2615	65	7	pronethanol	pronethanol	NOUN
fnp-2615	65	8	,	,	PUNCT
fnp-2615	65	9	which	which	PRON
fnp-2615	65	10	was	be	AUX
fnp-2615	65	11	shown	show	VERB
fnp-2615	65	12	to	to	PART
fnp-2615	65	13	effectively	effectively	ADV
fnp-2615	65	14	reduce	reduce	VERB
fnp-2615	65	15	sox2	sox2	NOUN
fnp-2615	65	16	expression	expression	NOUN
fnp-2615	65	17	.	.	PUNCT
fnp-2615	66	1	furthermore	furthermore	ADV
fnp-2615	66	2	,	,	PUNCT
fnp-2615	66	3	treatment	treatment	NOUN
fnp-2615	66	4	of	of	ADP
fnp-2615	66	5	mgp-/mice	mgp-/mice	PROPN
fnp-2615	66	6	with	with	ADP
fnp-2615	66	7	pronethanol	pronethanol	NOUN
fnp-2615	66	8	for	for	ADP
fnp-2615	66	9	14	14	NUM
fnp-2615	66	10	days	day	NOUN
fnp-2615	66	11	improved	improve	VERB
fnp-2615	66	12	the	the	DET
fnp-2615	66	13	cerebral	cerebral	ADJ
fnp-2615	66	14	vasculature	vasculature	NOUN
fnp-2615	66	15	in	in	ADP
fnp-2615	66	16	avm	avm	PROPN
fnp-2615	66	17	.	.	PUNCT
fnp-2615	67	1	interestingly	interestingly	ADV
fnp-2615	67	2	,	,	PUNCT
fnp-2615	67	3	pronethanol	pronethanol	PROPN
fnp-2615	67	4	is	be	AUX
fnp-2615	67	5	a	a	DET
fnp-2615	67	6	non	non	ADJ
fnp-2615	67	7	-	-	ADJ
fnp-2615	67	8	selective	selective	ADJ
fnp-2615	67	9	beta	beta	NOUN
fnp-2615	67	10	-	-	PUNCT
fnp-2615	67	11	blocker	blocker	NOUN
fnp-2615	67	12	with	with	ADP
fnp-2615	67	13	the	the	DET
fnp-2615	67	14	drawback	drawback	NOUN
fnp-2615	67	15	of	of	ADP
fnp-2615	67	16	causing	cause	VERB
fnp-2615	67	17	neurological	neurological	ADJ
fnp-2615	67	18	side	side	NOUN
fnp-2615	67	19	effects	effect	NOUN
fnp-2615	67	20	in	in	ADP
fnp-2615	67	21	humans	human	NOUN
fnp-2615	67	22	and	and	CCONJ
fnp-2615	67	23	carcinogenesis	carcinogenesis	NOUN
fnp-2615	67	24	in	in	ADP
fnp-2615	67	25	mice	mouse	NOUN
fnp-2615	67	26	.	.	PUNCT
fnp-2615	68	1	a	a	DET
fnp-2615	68	2	number	number	NOUN
fnp-2615	68	3	of	of	ADP
fnp-2615	68	4	ß	ß	DET
fnp-2615	68	5	-	-	ADJ
fnp-2615	68	6	adrenergic	adrenergic	ADJ
fnp-2615	68	7	drugs	drug	NOUN
fnp-2615	68	8	were	be	AUX
fnp-2615	68	9	subsequently	subsequently	ADV
fnp-2615	68	10	tested	test	VERB
fnp-2615	68	11	.	.	PUNCT
fnp-2615	69	1	the	the	DET
fnp-2615	69	2	results	result	NOUN
fnp-2615	69	3	showed	show	VERB
fnp-2615	69	4	that	that	SCONJ
fnp-2615	69	5	ß	ß	ADJ
fnp-2615	69	6	-	-	ADJ
fnp-2615	69	7	adrenergic	adrenergic	ADJ
fnp-2615	69	8	antagonists	antagonist	NOUN
fnp-2615	69	9	decreased	decrease	VERB
fnp-2615	69	10	sox2	sox2	NOUN
fnp-2615	69	11	and	and	CCONJ
fnp-2615	69	12	endmt	endmt	NOUN
fnp-2615	69	13	,	,	PUNCT
fnp-2615	69	14	and	and	CCONJ
fnp-2615	69	15	improved	improved	ADJ
fnp-2615	69	16	lumen	luman	NOUN
fnp-2615	69	17	formation	formation	NOUN
fnp-2615	69	18	.	.	PUNCT
fnp-2615	70	1	this	this	DET
fnp-2615	70	2	study	study	NOUN
fnp-2615	70	3	is	be	AUX
fnp-2615	70	4	a	a	DET
fnp-2615	70	5	good	good	ADJ
fnp-2615	70	6	example	example	NOUN
fnp-2615	70	7	of	of	ADP
fnp-2615	70	8	the	the	DET
fnp-2615	70	9	way	way	NOUN
fnp-2615	70	10	mechanistic	mechanistic	ADJ
fnp-2615	70	11	studies	study	NOUN
fnp-2615	70	12	in	in	ADP
fnp-2615	70	13	human	human	ADJ
fnp-2615	70	14	tissue	tissue	NOUN
fnp-2615	70	15	,	,	PUNCT
fnp-2615	70	16	human	human	ADJ
fnp-2615	70	17	cells	cell	NOUN
fnp-2615	70	18	,	,	PUNCT
fnp-2615	70	19	and	and	CCONJ
fnp-2615	70	20	animal	animal	NOUN
fnp-2615	70	21	models	model	NOUN
fnp-2615	70	22	lead	lead	VERB
fnp-2615	70	23	to	to	ADP
fnp-2615	70	24	the	the	DET
fnp-2615	70	25	discovery	discovery	NOUN
fnp-2615	70	26	of	of	ADP
fnp-2615	70	27	potential	potential	ADJ
fnp-2615	70	28	drugs	drug	NOUN
fnp-2615	70	29	to	to	PART
fnp-2615	70	30	improve	improve	VERB
fnp-2615	70	31	the	the	DET
fnp-2615	70	32	disease	disease	NOUN
fnp-2615	70	33	.	.	PUNCT
fnp-2615	71	1	previous	previous	ADJ
fnp-2615	71	2	studies	study	NOUN
fnp-2615	71	3	in	in	ADP
fnp-2615	71	4	mgp-/mice	mgp-/mice	PROPN
fnp-2615	71	5	had	have	AUX
fnp-2615	71	6	shown	show	VERB
fnp-2615	71	7	the	the	DET
fnp-2615	71	8	contribution	contribution	NOUN
fnp-2615	71	9	of	of	ADP
fnp-2615	71	10	endmt	endmt	PROPN
fnp-2615	71	11	and	and	CCONJ
fnp-2615	71	12	the	the	DET
fnp-2615	71	13	emergence	emergence	NOUN
fnp-2615	71	14	of	of	ADP
fnp-2615	71	15	multipotent	multipotent	NOUN
fnp-2615	71	16	cells	cell	NOUN
fnp-2615	71	17	to	to	ADP
fnp-2615	71	18	the	the	DET
fnp-2615	71	19	process	process	NOUN
fnp-2615	71	20	of	of	ADP
fnp-2615	71	21	ossification	ossification	NOUN
fnp-2615	71	22	and	and	CCONJ
fnp-2615	71	23	vascular	vascular	ADJ
fnp-2615	71	24	calcification	calcification	NOUN
fnp-2615	71	25	(	(	PUNCT
fnp-2615	71	26	e.g.	e.g.	ADV
fnp-2615	71	27	yao	yao	NOUN
fnp-2615	71	28	et	et	PROPN
fnp-2615	71	29	al	al	PROPN
fnp-2615	71	30	.	.	PROPN
fnp-2615	71	31	,	,	PUNCT
fnp-2615	71	32	2013	2013	NUM
fnp-2615	71	33	)	)	PUNCT
fnp-2615	71	34	.	.	PUNCT
fnp-2615	72	1	like	like	INTJ
fnp-2615	72	2	in	in	ADP
fnp-2615	72	3	the	the	DET
fnp-2615	72	4	case	case	NOUN
fnp-2615	72	5	of	of	ADP
fnp-2615	72	6	ccms	ccms	NOUN
fnp-2615	72	7	,	,	PUNCT
fnp-2615	72	8	failure	failure	NOUN
fnp-2615	72	9	of	of	ADP
fnp-2615	72	10	brain	brain	NOUN
fnp-2615	72	11	endothelial	endothelial	ADJ
fnp-2615	72	12	cells	cell	NOUN
fnp-2615	72	13	to	to	PART
fnp-2615	72	14	acquire	acquire	VERB
fnp-2615	72	15	or	or	CCONJ
fnp-2615	72	16	maintain	maintain	VERB
fnp-2615	72	17	their	their	PRON
fnp-2615	72	18	differentiation	differentiation	NOUN
fnp-2615	72	19	state	state	NOUN
fnp-2615	72	20	generates	generate	VERB
fnp-2615	72	21	aberrant	aberrant	ADJ
fnp-2615	72	22	vessels	vessel	NOUN
fnp-2615	72	23	and	and	CCONJ
fnp-2615	72	24	vascular	vascular	ADJ
fnp-2615	72	25	diseases	disease	NOUN
fnp-2615	72	26	.	.	PUNCT
fnp-2615	73	1	3	3	X
fnp-2615	73	2	.	.	X
fnp-2615	73	3	arterial	arterial	ADJ
fnp-2615	73	4	stiffness	stiffness	NOUN
fnp-2615	73	5	and	and	CCONJ
fnp-2615	73	6	calcifications	calcification	NOUN
fnp-2615	73	7	:	:	PUNCT
fnp-2615	73	8	molecular	molecular	ADJ
fnp-2615	73	9	insights	insight	NOUN
fnp-2615	73	10	and	and	CCONJ
fnp-2615	73	11	consequences	consequence	VERB
fnp-2615	73	12	vessel	vessel	NOUN
fnp-2615	73	13	calcification	calcification	NOUN
fnp-2615	73	14	and	and	CCONJ
fnp-2615	73	15	arterial	arterial	ADJ
fnp-2615	73	16	stiffness	stiffness	NOUN
fnp-2615	73	17	are	be	AUX
fnp-2615	73	18	common	common	ADJ
fnp-2615	73	19	in	in	ADP
fnp-2615	73	20	the	the	DET
fnp-2615	73	21	aged	aged	ADJ
fnp-2615	73	22	population	population	NOUN
fnp-2615	73	23	.	.	PUNCT
fnp-2615	74	1	arterial	arterial	ADJ
fnp-2615	74	2	stiffness	stiffness	NOUN
fnp-2615	74	3	is	be	AUX
fnp-2615	74	4	caused	cause	VERB
fnp-2615	74	5	by	by	ADP
fnp-2615	74	6	structural	structural	ADJ
fnp-2615	74	7	alterations	alteration	NOUN
fnp-2615	74	8	reducing	reduce	VERB
fnp-2615	74	9	arterial	arterial	ADJ
fnp-2615	74	10	wall	wall	NOUN
fnp-2615	74	11	distensibility	distensibility	NOUN
fnp-2615	74	12	and	and	CCONJ
fnp-2615	74	13	the	the	DET
fnp-2615	74	14	arterial	arterial	ADJ
fnp-2615	74	15	capacity	capacity	NOUN
fnp-2615	74	16	to	to	PART
fnp-2615	74	17	buffer	buffer	VERB
fnp-2615	74	18	pulsatile	pulsatile	VERB
fnp-2615	74	19	cardiac	cardiac	ADJ
fnp-2615	74	20	ejection	ejection	NOUN
fnp-2615	74	21	.	.	PUNCT
fnp-2615	75	1	this	this	DET
fnp-2615	75	2	condition	condition	NOUN
fnp-2615	75	3	is	be	AUX
fnp-2615	75	4	epidemiologically	epidemiologically	ADV
fnp-2615	75	5	associated	associate	VERB
fnp-2615	75	6	with	with	ADP
fnp-2615	75	7	hypertension	hypertension	NOUN
fnp-2615	75	8	and	and	CCONJ
fnp-2615	75	9	cognitive	cognitive	ADJ
fnp-2615	75	10	decline	decline	NOUN
fnp-2615	75	11	.	.	PUNCT
fnp-2615	76	1	arterial	arterial	ADJ
fnp-2615	76	2	calcification	calcification	NOUN
fnp-2615	76	3	is	be	AUX
fnp-2615	76	4	an	an	DET
fnp-2615	76	5	important	important	ADJ
fnp-2615	76	6	cause	cause	NOUN
fnp-2615	76	7	of	of	ADP
fnp-2615	76	8	arterial	arterial	ADJ
fnp-2615	76	9	stiffness	stiffness	NOUN
fnp-2615	76	10	but	but	CCONJ
fnp-2615	76	11	the	the	DET
fnp-2615	76	12	contribution	contribution	NOUN
fnp-2615	76	13	of	of	ADP
fnp-2615	76	14	calcifications	calcification	NOUN
fnp-2615	76	15	to	to	ADP
fnp-2615	76	16	cognitive	cognitive	ADJ
fnp-2615	76	17	decline	decline	NOUN
fnp-2615	76	18	over	over	ADP
fnp-2615	76	19	other	other	ADJ
fnp-2615	76	20	associated	associated	ADJ
fnp-2615	76	21	features	feature	NOUN
fnp-2615	76	22	is	be	AUX
fnp-2615	76	23	unclear	unclear	ADJ
fnp-2615	76	24	.	.	PUNCT
fnp-2615	77	1	muhire	muhire	NOUN
fnp-2615	77	2	et	et	PROPN
fnp-2615	77	3	al	al	PROPN
fnp-2615	77	4	.	.	PROPN
fnp-2615	78	1	(	(	PUNCT
fnp-2615	78	2	2019	2019	NUM
fnp-2615	78	3	)	)	PUNCT
fnp-2615	78	4	showed	show	VERB
fnp-2615	78	5	in	in	ADP
fnp-2615	78	6	experimental	experimental	ADJ
fnp-2615	78	7	animals	animal	NOUN
fnp-2615	78	8	that	that	PRON
fnp-2615	78	9	carotid	carotid	VERB
fnp-2615	78	10	calcification	calcification	NOUN
fnp-2615	78	11	attenuated	attenuate	VERB
fnp-2615	78	12	resting	rest	VERB
fnp-2615	78	13	cerebral	cerebral	ADJ
fnp-2615	78	14	blood	blood	NOUN
fnp-2615	78	15	flow	flow	NOUN
fnp-2615	78	16	(	(	PUNCT
fnp-2615	78	17	cbf	cbf	PROPN
fnp-2615	78	18	)	)	PUNCT
fnp-2615	78	19	,	,	PUNCT
fnp-2615	78	20	impaired	impaired	ADJ
fnp-2615	78	21	cerebral	cerebral	ADJ
fnp-2615	78	22	autoregulation	autoregulation	NOUN
fnp-2615	78	23	,	,	PUNCT
fnp-2615	78	24	and	and	CCONJ
fnp-2615	78	25	induced	induce	VERB
fnp-2615	78	26	cognitive	cognitive	ADJ
fnp-2615	78	27	deficits	deficit	NOUN
fnp-2615	78	28	.	.	PUNCT
fnp-2615	79	1	the	the	DET
fnp-2615	79	2	study	study	NOUN
fnp-2615	79	3	used	use	VERB
fnp-2615	79	4	a	a	DET
fnp-2615	79	5	mouse	mouse	NOUN
fnp-2615	79	6	model	model	NOUN
fnp-2615	79	7	of	of	ADP
fnp-2615	79	8	arterial	arterial	ADJ
fnp-2615	79	9	stiffness	stiffness	NOUN
fnp-2615	79	10	induced	induce	VERB
fnp-2615	79	11	by	by	ADP
fnp-2615	79	12	direct	direct	ADJ
fnp-2615	79	13	application	application	NOUN
fnp-2615	79	14	of	of	ADP
fnp-2615	79	15	cacl2	cacl2	NOUN
fnp-2615	79	16	on	on	ADP
fnp-2615	79	17	the	the	DET
fnp-2615	79	18	carotid	carotid	NOUN
fnp-2615	79	19	artery	artery	NOUN
fnp-2615	79	20	.	.	PUNCT
fnp-2615	80	1	the	the	DET
fnp-2615	80	2	model	model	NOUN
fnp-2615	80	3	is	be	AUX
fnp-2615	80	4	characterized	characterize	VERB
fnp-2615	80	5	by	by	ADP
fnp-2615	80	6	reduced	reduce	VERB
fnp-2615	80	7	arterial	arterial	ADJ
fnp-2615	80	8	compliance	compliance	NOUN
fnp-2615	80	9	and	and	CCONJ
fnp-2615	80	10	distensibility	distensibility	NOUN
fnp-2615	80	11	,	,	PUNCT
fnp-2615	80	12	increased	increase	VERB
fnp-2615	80	13	thickness	thickness	NOUN
fnp-2615	80	14	of	of	ADP
fnp-2615	80	15	the	the	DET
fnp-2615	80	16	intima	intima	NOUN
fnp-2615	80	17	-	-	PUNCT
fnp-2615	80	18	media	medium	NOUN
fnp-2615	80	19	,	,	PUNCT
fnp-2615	80	20	and	and	CCONJ
fnp-2615	80	21	fragmentation	fragmentation	NOUN
fnp-2615	80	22	of	of	ADP
fnp-2615	80	23	the	the	DET
fnp-2615	80	24	internal	internal	ADJ
fnp-2615	80	25	elastic	elastic	ADJ
fnp-2615	80	26	lamina	lamina	NOUN
fnp-2615	80	27	,	,	PUNCT
fnp-2615	80	28	without	without	ADP
fnp-2615	80	29	increased	increase	VERB
fnp-2615	80	30	systolic	systolic	ADJ
fnp-2615	80	31	blood	blood	NOUN
fnp-2615	80	32	pressure	pressure	NOUN
fnp-2615	80	33	.	.	PUNCT
fnp-2615	81	1	carotid	carotid	NOUN
fnp-2615	81	2	stiffness	stiffness	NOUN
fnp-2615	81	3	increased	increase	VERB
fnp-2615	81	4	bbb	bbb	NOUN
fnp-2615	81	5	permeability	permeability	NOUN
fnp-2615	81	6	in	in	ADP
fnp-2615	81	7	the	the	DET
fnp-2615	81	8	hippocampus	hippocampus	NOUN
fnp-2615	81	9	where	where	SCONJ
fnp-2615	81	10	the	the	DET
fnp-2615	81	11	number	number	NOUN
fnp-2615	81	12	of	of	ADP
fnp-2615	81	13	collagen	collagen	NOUN
fnp-2615	81	14	iv+	iv+	ADJ
fnp-2615	81	15	vessels	vessel	NOUN
fnp-2615	81	16	decreased	decrease	VERB
fnp-2615	81	17	,	,	PUNCT
fnp-2615	81	18	suggesting	suggest	VERB
fnp-2615	81	19	a	a	DET
fnp-2615	81	20	pathogenic	pathogenic	ADJ
fnp-2615	81	21	role	role	NOUN
fnp-2615	81	22	of	of	ADP
fnp-2615	81	23	these	these	DET
fnp-2615	81	24	calcifications	calcification	NOUN
fnp-2615	81	25	.	.	PUNCT
fnp-2615	82	1	regarding	regard	VERB
fnp-2615	82	2	the	the	DET
fnp-2615	82	3	molecular	molecular	ADJ
fnp-2615	82	4	mechanisms	mechanism	NOUN
fnp-2615	82	5	underlying	underlie	VERB
fnp-2615	82	6	vessel	vessel	NOUN
fnp-2615	82	7	calcifications	calcification	NOUN
fnp-2615	82	8	in	in	ADP
fnp-2615	82	9	brain	brain	NOUN
fnp-2615	82	10	arteries	artery	NOUN
fnp-2615	82	11	,	,	PUNCT
fnp-2615	82	12	a	a	DET
fnp-2615	82	13	recent	recent	ADJ
fnp-2615	82	14	study	study	NOUN
fnp-2615	82	15	pointed	point	VERB
fnp-2615	82	16	to	to	ADP
fnp-2615	82	17	the	the	DET
fnp-2615	82	18	involvement	involvement	NOUN
fnp-2615	82	19	of	of	ADP
fnp-2615	82	20	osteopontin	osteopontin	NOUN
fnp-2615	82	21	and	and	CCONJ
fnp-2615	82	22	tgfβ	tgfβ	ADJ
fnp-2615	82	23	signaling	signal	VERB
fnp-2615	82	24	in	in	ADP
fnp-2615	82	25	the	the	DET
fnp-2615	82	26	pathogenesis	pathogenesis	NOUN
fnp-2615	82	27	of	of	ADP
fnp-2615	82	28	calcifications	calcification	NOUN
fnp-2615	82	29	(	(	PUNCT
fnp-2615	82	30	grand	grand	ADJ
fnp-2615	82	31	moursel	moursel	NOUN
fnp-2615	82	32	et	et	PROPN
fnp-2615	82	33	al	al	PROPN
fnp-2615	82	34	.	.	PROPN
fnp-2615	82	35	,	,	PUNCT
fnp-2615	82	36	2019	2019	NUM
fnp-2615	82	37	)	)	PUNCT
fnp-2615	82	38	.	.	PUNCT
fnp-2615	83	1	osteopontin	osteopontin	NOUN
fnp-2615	83	2	is	be	AUX
fnp-2615	83	3	an	an	DET
fnp-2615	83	4	extracellular	extracellular	ADJ
fnp-2615	83	5	glycoprotein	glycoprotein	NOUN
fnp-2615	83	6	with	with	ADP
fnp-2615	83	7	diverse	diverse	ADJ
fnp-2615	83	8	features	feature	NOUN
fnp-2615	83	9	.	.	PUNCT
fnp-2615	84	1	it	it	PRON
fnp-2615	84	2	is	be	AUX
fnp-2615	84	3	cleaved	cleave	VERB
fnp-2615	84	4	by	by	ADP
fnp-2615	84	5	thrombin	thrombin	NOUN
fnp-2615	84	6	and	and	CCONJ
fnp-2615	84	7	cleaved	cleaved	ADJ
fnp-2615	84	8	forms	form	NOUN
fnp-2615	84	9	can	can	AUX
fnp-2615	84	10	bind	bind	VERB
fnp-2615	84	11	to	to	ADP
fnp-2615	84	12	several	several	ADJ
fnp-2615	84	13	integrin	integrin	NOUN
fnp-2615	84	14	receptors	receptor	NOUN
fnp-2615	84	15	expressed	express	VERB
fnp-2615	84	16	by	by	ADP
fnp-2615	84	17	immune	immune	ADJ
fnp-2615	84	18	cells	cell	NOUN
fnp-2615	84	19	.	.	PUNCT
fnp-2615	85	1	given	give	VERB
fnp-2615	85	2	that	that	DET
fnp-2615	85	3	vascular	vascular	ADJ
fnp-2615	85	4	calcifications	calcification	NOUN
fnp-2615	85	5	are	be	AUX
fnp-2615	85	6	detected	detect	VERB
fnp-2615	85	7	in	in	ADP
fnp-2615	85	8	the	the	DET
fnp-2615	85	9	cerebral	cerebral	ADJ
fnp-2615	85	10	cortex	cortex	NOUN
fnp-2615	85	11	in	in	ADP
fnp-2615	85	12	severe	severe	ADJ
fnp-2615	85	13	forms	form	NOUN
fnp-2615	85	14	of	of	ADP
fnp-2615	85	15	cerebral	cerebral	ADJ
fnp-2615	85	16	amyloid	amyloid	NOUN
fnp-2615	85	17	angiopathy	angiopathy	ADJ
fnp-2615	85	18	(	(	PUNCT
fnp-2615	85	19	caa	caa	NOUN
fnp-2615	85	20	)	)	PUNCT
fnp-2615	85	21	,	,	PUNCT
fnp-2615	85	22	the	the	DET
fnp-2615	85	23	study	study	NOUN
fnp-2615	85	24	investigated	investigate	VERB
fnp-2615	85	25	molecular	molecular	ADJ
fnp-2615	85	26	modulators	modulator	NOUN
fnp-2615	85	27	of	of	ADP
fnp-2615	85	28	arterial	arterial	ADJ
fnp-2615	85	29	calcifications	calcification	NOUN
fnp-2615	85	30	in	in	ADP
fnp-2615	85	31	post	post	ADJ
fnp-2615	85	32	-	-	ADJ
fnp-2615	85	33	mortem	mortem	ADJ
fnp-2615	85	34	tissue	tissue	NOUN
fnp-2615	85	35	of	of	ADP
fnp-2615	85	36	eight	eight	NUM
fnp-2615	85	37	patients	patient	NOUN
fnp-2615	85	38	with	with	ADP
fnp-2615	85	39	hereditary	hereditary	ADJ
fnp-2615	85	40	cerebral	cerebral	ADJ
fnp-2615	85	41	hemorrhage	hemorrhage	NOUN
fnp-2615	85	42	with	with	ADP
fnp-2615	85	43	amyloidosis	amyloidosis	NOUN
fnp-2615	85	44	-	-	PUNCT
fnp-2615	85	45	dutch	dutch	NOUN
fnp-2615	85	46	type	type	NOUN
fnp-2615	85	47	(	(	PUNCT
fnp-2615	85	48	hchwa	hchwa	PROPN
fnp-2615	85	49	-	-	PUNCT
fnp-2615	85	50	d	d	PROPN
fnp-2615	85	51	or	or	CCONJ
fnp-2615	85	52	d	d	NOUN
fnp-2615	85	53	-	-	NOUN
fnp-2615	85	54	caa	caa	NOUN
fnp-2615	85	55	)	)	PUNCT
fnp-2615	85	56	.	.	PUNCT
fnp-2615	86	1	calcified	calcified	ADJ
fnp-2615	86	2	vessel	vessel	NOUN
fnp-2615	86	3	walls	wall	NOUN
fnp-2615	86	4	showed	show	VERB
fnp-2615	86	5	overexpression	overexpression	NOUN
fnp-2615	86	6	of	of	ADP
fnp-2615	86	7	medial	medial	ADJ
fnp-2615	86	8	and	and	CCONJ
fnp-2615	86	9	abluminal	abluminal	ADJ
fnp-2615	86	10	collagen	collagen	NOUN
fnp-2615	86	11	type	type	NOUN
fnp-2615	86	12	i.	i.	NOUN
fnp-2615	86	13	they	they	PRON
fnp-2615	86	14	also	also	ADV
fnp-2615	86	15	overexpressed	overexpresse	VERB
fnp-2615	86	16	osteopontin	osteopontin	NOUN
fnp-2615	86	17	and	and	CCONJ
fnp-2615	86	18	tgfβ	tgfβ	ADJ
fnp-2615	86	19	signaling	signal	VERB
fnp-2615	86	20	factor	factor	NOUN
fnp-2615	86	21	phospho	phospho	NOUN
fnp-2615	86	22	-	-	PUNCT
fnp-2615	86	23	smad2/3	smad2/3	NOUN
fnp-2615	86	24	,	,	PUNCT
fnp-2615	86	25	and	and	CCONJ
fnp-2615	86	26	accumulation	accumulation	NOUN
fnp-2615	86	27	of	of	ADP
fnp-2615	86	28	these	these	DET
fnp-2615	86	29	factors	factor	NOUN
fnp-2615	86	30	preceded	precede	VERB
fnp-2615	86	31	overt	overt	ADJ
fnp-2615	86	32	vessel	vessel	NOUN
fnp-2615	86	33	calcifications	calcification	NOUN
fnp-2615	86	34	.	.	PUNCT
fnp-2615	87	1	the	the	DET
fnp-2615	87	2	study	study	NOUN
fnp-2615	87	3	found	find	VERB
fnp-2615	87	4	significant	significant	ADJ
fnp-2615	87	5	positive	positive	ADJ
fnp-2615	87	6	correlations	correlation	NOUN
fnp-2615	87	7	between	between	ADP
fnp-2615	87	8	the	the	DET
fnp-2615	87	9	level	level	NOUN
fnp-2615	87	10	of	of	ADP
fnp-2615	87	11	osteopontin	osteopontin	NOUN
fnp-2615	87	12	and	and	CCONJ
fnp-2615	87	13	phospho	phospho	ADJ
fnp-2615	87	14	-	-	PUNCT
fnp-2615	87	15	smad2/3	smad2/3	NOUN
fnp-2615	87	16	and	and	CCONJ
fnp-2615	87	17	disease	disease	NOUN
fnp-2615	87	18	severity	severity	NOUN
fnp-2615	87	19	and	and	CCONJ
fnp-2615	87	20	suggested	suggest	VERB
fnp-2615	87	21	the	the	DET
fnp-2615	87	22	involvement	involvement	NOUN
fnp-2615	87	23	of	of	ADP
fnp-2615	87	24	these	these	DET
fnp-2615	87	25	molecules	molecule	NOUN
fnp-2615	87	26	in	in	ADP
fnp-2615	87	27	cerebral	cerebral	ADJ
fnp-2615	87	28	artery	artery	NOUN
fnp-2615	87	29	calcifications	calcification	NOUN
fnp-2615	87	30	in	in	ADP
fnp-2615	87	31	caa	caa	NOUN
fnp-2615	87	32	.	.	PUNCT
fnp-2615	88	1	more	more	ADV
fnp-2615	88	2	severe	severe	ADJ
fnp-2615	88	3	brain	brain	NOUN
fnp-2615	88	4	vessel	vessel	NOUN
fnp-2615	88	5	calcifications	calcification	NOUN
fnp-2615	88	6	are	be	AUX
fnp-2615	88	7	found	find	VERB
fnp-2615	88	8	in	in	ADP
fnp-2615	88	9	certain	certain	ADJ
fnp-2615	88	10	rare	rare	ADJ
fnp-2615	88	11	genetic	genetic	ADJ
fnp-2615	88	12	diseases	disease	NOUN
fnp-2615	88	13	.	.	PUNCT
fnp-2615	89	1	primary	primary	ADJ
fnp-2615	89	2	familial	familial	ADJ
fnp-2615	89	3	brain	brain	NOUN
fnp-2615	89	4	calcification	calcification	NOUN
fnp-2615	89	5	(	(	PUNCT
fnp-2615	89	6	pfbc	pfbc	PROPN
fnp-2615	89	7	)	)	PUNCT
fnp-2615	89	8	is	be	AUX
fnp-2615	89	9	a	a	DET
fnp-2615	89	10	heritable	heritable	ADJ
fnp-2615	89	11	disease	disease	NOUN
fnp-2615	89	12	also	also	ADV
fnp-2615	89	13	termed	term	VERB
fnp-2615	89	14	fahr	fahr	PROPN
fnp-2615	89	15	’s	’s	PART
fnp-2615	89	16	disease	disease	NOUN
fnp-2615	89	17	.	.	PUNCT
fnp-2615	90	1	it	it	PRON
fnp-2615	90	2	is	be	AUX
fnp-2615	90	3	a	a	DET
fnp-2615	90	4	rare	rare	ADJ
fnp-2615	90	5	form	form	NOUN
fnp-2615	90	6	of	of	ADP
fnp-2615	90	7	brain	brain	NOUN
fnp-2615	90	8	calcification	calcification	NOUN
fnp-2615	90	9	affecting	affect	VERB
fnp-2615	90	10	vessels	vessel	NOUN
fnp-2615	90	11	of	of	ADP
fnp-2615	90	12	the	the	DET
fnp-2615	90	13	basal	basal	ADJ
fnp-2615	90	14	ganglia	ganglia	NOUN
fnp-2615	90	15	and	and	CCONJ
fnp-2615	90	16	often	often	ADV
fnp-2615	90	17	manifests	manifest	VERB
fnp-2615	90	18	with	with	ADP
fnp-2615	90	19	neuropsychiatric	neuropsychiatric	ADJ
fnp-2615	90	20	symptoms	symptom	NOUN
fnp-2615	90	21	.	.	PUNCT
fnp-2615	91	1	zarb	zarb	NOUN
fnp-2615	91	2	et	et	PROPN
fnp-2615	91	3	al	al	PROPN
fnp-2615	91	4	.	.	PROPN
fnp-2615	92	1	(	(	PUNCT
fnp-2615	92	2	2019	2019	NUM
fnp-2615	92	3	)	)	PUNCT
fnp-2615	92	4	used	use	VERB
fnp-2615	92	5	a	a	DET
fnp-2615	92	6	mouse	mouse	NOUN
fnp-2615	92	7	model	model	NOUN
fnp-2615	92	8	with	with	ADP
fnp-2615	92	9	mutations	mutation	NOUN
fnp-2615	92	10	in	in	ADP
fnp-2615	92	11	platelet	platelet	ADJ
fnp-2615	92	12	-	-	PUNCT
fnp-2615	92	13	derived	derive	VERB
fnp-2615	92	14	growth	growth	NOUN
fnp-2615	92	15	factor	factor	NOUN
fnp-2615	92	16	subunit	subunit	NOUN
fnp-2615	92	17	-	-	PUNCT
fnp-2615	92	18	β	β	X
fnp-2615	92	19	(	(	PUNCT
fnp-2615	92	20	pdgfb	pdgfb	NOUN
fnp-2615	92	21	)	)	PUNCT
fnp-2615	92	22	gene	gene	NOUN
fnp-2615	92	23	causing	cause	VERB
fnp-2615	92	24	reduced	reduce	VERB
fnp-2615	92	25	endothelial	endothelial	ADJ
fnp-2615	92	26	expression	expression	NOUN
fnp-2615	92	27	of	of	ADP
fnp-2615	92	28	this	this	DET
fnp-2615	92	29	factor	factor	NOUN
fnp-2615	92	30	,	,	PUNCT
fnp-2615	92	31	resulting	result	VERB
fnp-2615	92	32	in	in	ADP
fnp-2615	92	33	vascular	vascular	ADJ
fnp-2615	92	34	calcifications	calcification	NOUN
fnp-2615	92	35	associated	associate	VERB
fnp-2615	92	36	with	with	ADP
fnp-2615	92	37	pericyte	pericyte	NOUN
fnp-2615	92	38	loss	loss	NOUN
fnp-2615	92	39	and	and	CCONJ
fnp-2615	92	40	bbb	bbb	NOUN
fnp-2615	92	41	alterations	alteration	NOUN
fnp-2615	92	42	.	.	PUNCT
fnp-2615	93	1	interestingly	interestingly	ADV
fnp-2615	93	2	,	,	PUNCT
fnp-2615	93	3	the	the	DET
fnp-2615	93	4	mouse	mouse	NOUN
fnp-2615	93	5	model	model	NOUN
fnp-2615	93	6	recapitulated	recapitulate	VERB
fnp-2615	93	7	several	several	ADJ
fnp-2615	93	8	behavioral	behavioral	ADJ
fnp-2615	93	9	alterations	alteration	NOUN
fnp-2615	93	10	overlapping	overlap	VERB
fnp-2615	93	11	with	with	ADP
fnp-2615	93	12	pfbc	pfbc	PROPN
fnp-2615	93	13	,	,	PUNCT
fnp-2615	93	14	including	include	VERB
fnp-2615	93	15	sensorimotor	sensorimotor	NOUN
fnp-2615	93	16	deficits	deficit	NOUN
fnp-2615	93	17	,	,	PUNCT
fnp-2615	93	18	hyperactivity	hyperactivity	NOUN
fnp-2615	93	19	,	,	PUNCT
fnp-2615	93	20	anxiety	anxiety	NOUN
fnp-2615	93	21	and	and	CCONJ
fnp-2615	93	22	impaired	impaired	ADJ
fnp-2615	93	23	working	working	NOUN
fnp-2615	93	24	memory	memory	NOUN
fnp-2615	93	25	.	.	PUNCT
fnp-2615	94	1	cells	cell	NOUN
fnp-2615	94	2	surrounding	surround	VERB
fnp-2615	94	3	brain	brain	NOUN
fnp-2615	94	4	vessel	vessel	NOUN
fnp-2615	94	5	calcifications	calcification	NOUN
fnp-2615	94	6	expressed	express	VERB
fnp-2615	94	7	osteoblast	osteoblast	ADJ
fnp-2615	94	8	,	,	PUNCT
fnp-2615	94	9	osteoclast	osteoclast	ADJ
fnp-2615	94	10	,	,	PUNCT
fnp-2615	94	11	and	and	CCONJ
fnp-2615	94	12	osteocyte	osteocyte	NOUN
fnp-2615	94	13	markers	marker	NOUN
fnp-2615	94	14	.	.	PUNCT
fnp-2615	95	1	the	the	DET
fnp-2615	95	2	extracellular	extracellular	ADJ
fnp-2615	95	3	matrix	matrix	NOUN
fnp-2615	95	4	contained	contain	VERB
fnp-2615	95	5	bone	bone	NOUN
fnp-2615	95	6	matrix	matrix	NOUN
fnp-2615	95	7	proteins	protein	NOUN
fnp-2615	95	8	.	.	PUNCT
fnp-2615	96	1	importantly	importantly	ADV
fnp-2615	96	2	,	,	PUNCT
fnp-2615	96	3	blood	blood	NOUN
fnp-2615	96	4	vessel	vessel	NOUN
fnp-2615	96	5	ossification	ossification	NOUN
fnp-2615	96	6	was	be	AUX
fnp-2615	96	7	also	also	ADV
fnp-2615	96	8	demonstrated	demonstrate	VERB
fnp-2615	96	9	in	in	ADP
fnp-2615	96	10	brain	brain	NOUN
fnp-2615	96	11	tissue	tissue	NOUN
fnp-2615	96	12	from	from	ADP
fnp-2615	96	13	primary	primary	ADJ
fnp-2615	96	14	familial	familial	ADJ
fnp-2615	96	15	brain	brain	NOUN
fnp-2615	96	16	calcification	calcification	NOUN
fnp-2615	96	17	patients	patient	NOUN
fnp-2615	96	18	.	.	PUNCT
fnp-2615	97	1	another	another	DET
fnp-2615	97	2	consequence	consequence	NOUN
fnp-2615	97	3	of	of	ADP
fnp-2615	97	4	vessel	vessel	NOUN
fnp-2615	97	5	calcifications	calcification	NOUN
fnp-2615	97	6	was	be	AUX
fnp-2615	97	7	activation	activation	NOUN
fnp-2615	97	8	of	of	ADP
fnp-2615	97	9	microglial	microglial	ADJ
fnp-2615	97	10	and	and	CCONJ
fnp-2615	97	11	astroglial	astroglial	ADJ
fnp-2615	97	12	cells	cell	NOUN
fnp-2615	97	13	.	.	PUNCT
fnp-2615	98	1	given	give	VERB
fnp-2615	98	2	the	the	DET
fnp-2615	98	3	reported	report	VERB
fnp-2615	98	4	astrogliosis	astrogliosis	NOUN
fnp-2615	98	5	in	in	ADP
fnp-2615	98	6	pfbc	pfbc	ADJ
fnp-2615	98	7	patients	patient	NOUN
fnp-2615	98	8	,	,	PUNCT
fnp-2615	98	9	astrocytes	astrocyte	NOUN
fnp-2615	98	10	were	be	AUX
fnp-2615	98	11	investigated	investigate	VERB
fnp-2615	98	12	in	in	ADP
fnp-2615	98	13	the	the	DET
fnp-2615	98	14	mouse	mouse	NOUN
fnp-2615	98	15	model	model	NOUN
fnp-2615	98	16	.	.	PUNCT
fnp-2615	99	1	notably	notably	ADV
fnp-2615	99	2	,	,	PUNCT
fnp-2615	99	3	gfap+	gfap+	ADJ
fnp-2615	99	4	astrocytes	astrocyte	NOUN
fnp-2615	99	5	surrounding	surround	VERB
fnp-2615	99	6	calcifications	calcification	NOUN
fnp-2615	99	7	expressed	express	VERB
fnp-2615	99	8	oxidative	oxidative	ADJ
fnp-2615	99	9	stress	stress	NOUN
fnp-2615	99	10	and	and	CCONJ
fnp-2615	99	11	inflammatory	inflammatory	ADJ
fnp-2615	99	12	neurotoxic	neurotoxic	ADJ
fnp-2615	99	13	markers	marker	NOUN
fnp-2615	99	14	,	,	PUNCT
fnp-2615	99	15	such	such	ADJ
fnp-2615	99	16	as	as	ADP
fnp-2615	99	17	complement	complement	NOUN
fnp-2615	99	18	component	component	NOUN
fnp-2615	99	19	3	3	NUM
fnp-2615	99	20	(	(	PUNCT
fnp-2615	99	21	c3	c3	PROPN
fnp-2615	99	22	)	)	PUNCT
fnp-2615	99	23	and	and	CCONJ
fnp-2615	99	24	lipocalin	lipocalin	PROPN
fnp-2615	99	25	2	2	NUM
fnp-2615	99	26	.	.	NOUN
fnp-2615	99	27	4	4	NUM
fnp-2615	99	28	.	.	X
fnp-2615	99	29	inflammation	inflammation	ADJ
fnp-2615	99	30	/	/	SYM
fnp-2615	99	31	innate	innate	ADJ
fnp-2615	99	32	immunity	immunity	NOUN
fnp-2615	99	33	:	:	PUNCT
fnp-2615	99	34	role	role	NOUN
fnp-2615	99	35	of	of	ADP
fnp-2615	99	36	complement	complement	NOUN
fnp-2615	99	37	activation	activation	NOUN
fnp-2615	99	38	inflammation	inflammation	NOUN
fnp-2615	99	39	is	be	AUX
fnp-2615	99	40	present	present	ADJ
fnp-2615	99	41	in	in	ADP
fnp-2615	99	42	most	most	ADJ
fnp-2615	99	43	brain	brain	NOUN
fnp-2615	99	44	diseases	disease	NOUN
fnp-2615	99	45	affecting	affect	VERB
fnp-2615	99	46	the	the	DET
fnp-2615	99	47	elderly	elderly	ADJ
fnp-2615	99	48	,	,	PUNCT
fnp-2615	99	49	including	include	VERB
fnp-2615	99	50	cerebrovascular	cerebrovascular	ADJ
fnp-2615	99	51	disease	disease	NOUN
fnp-2615	99	52	.	.	PUNCT
fnp-2615	100	1	recently	recently	ADV
fnp-2615	100	2	,	,	PUNCT
fnp-2615	100	3	activation	activation	NOUN
fnp-2615	100	4	of	of	ADP
fnp-2615	100	5	the	the	DET
fnp-2615	100	6	complement	complement	NOUN
fnp-2615	100	7	cascade	cascade	NOUN
fnp-2615	100	8	was	be	AUX
fnp-2615	100	9	shown	show	VERB
fnp-2615	100	10	to	to	PART
fnp-2615	100	11	play	play	VERB
fnp-2615	100	12	a	a	DET
fnp-2615	100	13	pathogenic	pathogenic	ADJ
fnp-2615	100	14	role	role	NOUN
fnp-2615	100	15	in	in	ADP
fnp-2615	100	16	subarachnoid	subarachnoid	NOUN
fnp-2615	100	17	hemorrhage	hemorrhage	NOUN
fnp-2615	100	18	.	.	PUNCT
fnp-2615	101	1	moreover	moreover	ADV
fnp-2615	101	2	,	,	PUNCT
fnp-2615	101	3	interaction	interaction	NOUN
fnp-2615	101	4	between	between	ADP
fnp-2615	101	5	initiator	initiator	NOUN
fnp-2615	101	6	complement	complement	NOUN
fnp-2615	101	7	component	component	NOUN
fnp-2615	101	8	c1q	c1q	NOUN
fnp-2615	101	9	and	and	CCONJ
fnp-2615	101	10	apoe	apoe	NOUN
fnp-2615	101	11	was	be	AUX
fnp-2615	101	12	reported	report	VERB
fnp-2615	101	13	.	.	PUNCT
fnp-2615	102	1	complement	complement	NOUN
fnp-2615	102	2	activation	activation	NOUN
fnp-2615	102	3	has	have	AUX
fnp-2615	102	4	been	be	AUX
fnp-2615	102	5	reported	report	VERB
fnp-2615	102	6	in	in	ADP
fnp-2615	102	7	cerebrovascular	cerebrovascular	ADJ
fnp-2615	102	8	diseases	disease	NOUN
fnp-2615	102	9	and	and	CCONJ
fnp-2615	102	10	several	several	ADJ
fnp-2615	102	11	lines	line	NOUN
fnp-2615	102	12	of	of	ADP
fnp-2615	102	13	evidence	evidence	NOUN
fnp-2615	102	14	strongly	strongly	ADV
fnp-2615	102	15	support	support	VERB
fnp-2615	102	16	the	the	DET
fnp-2615	102	17	involvement	involvement	NOUN
fnp-2615	102	18	of	of	ADP
fnp-2615	102	19	complement	complement	NOUN
fnp-2615	102	20	in	in	ADP
fnp-2615	102	21	secondary	secondary	ADJ
fnp-2615	102	22	tissue	tissue	NOUN
fnp-2615	102	23	injury	injury	NOUN
fnp-2615	102	24	following	follow	VERB
fnp-2615	102	25	acute	acute	ADJ
fnp-2615	102	26	stroke	stroke	NOUN
fnp-2615	102	27	.	.	PUNCT
fnp-2615	103	1	c3	c3	PROPN
fnp-2615	103	2	is	be	AUX
fnp-2615	103	3	amongst	amongst	ADP
fnp-2615	103	4	key	key	ADJ
fnp-2615	103	5	biomarkers	biomarker	NOUN
fnp-2615	103	6	associated	associate	VERB
fnp-2615	103	7	with	with	ADP
fnp-2615	103	8	increased	increase	VERB
fnp-2615	103	9	risk	risk	NOUN
fnp-2615	103	10	of	of	ADP
fnp-2615	103	11	major	major	ADJ
fnp-2615	103	12	disability	disability	NOUN
fnp-2615	103	13	,	,	PUNCT
fnp-2615	103	14	mortality	mortality	NOUN
fnp-2615	103	15	and	and	CCONJ
fnp-2615	103	16	vascular	vascular	ADJ
fnp-2615	103	17	events	event	NOUN
fnp-2615	103	18	following	follow	VERB
fnp-2615	103	19	ischemic	ischemic	ADJ
fnp-2615	103	20	stroke	stroke	NOUN
fnp-2615	103	21	(	(	PUNCT
fnp-2615	103	22	zhong	zhong	PROPN
fnp-2615	103	23	et	et	PROPN
fnp-2615	103	24	al	al	PROPN
fnp-2615	103	25	.	.	PROPN
fnp-2615	103	26	,	,	PUNCT
fnp-2615	103	27	2019	2019	NUM
fnp-2615	103	28	)	)	PUNCT
fnp-2615	103	29	.	.	PUNCT
fnp-2615	104	1	complement	complement	NOUN
fnp-2615	104	2	activation	activation	NOUN
fnp-2615	104	3	is	be	AUX
fnp-2615	104	4	also	also	ADV
fnp-2615	104	5	associated	associate	VERB
fnp-2615	104	6	with	with	ADP
fnp-2615	104	7	poor	poor	ADJ
fnp-2615	104	8	functional	functional	ADJ
fnp-2615	104	9	outcome	outcome	NOUN
fnp-2615	104	10	following	follow	VERB
fnp-2615	104	11	aneurysmal	aneurysmal	ADJ
fnp-2615	104	12	subarachnoid	subarachnoid	NOUN
fnp-2615	104	13	hemorrhage	hemorrhage	NOUN
fnp-2615	104	14	(	(	PUNCT
fnp-2615	104	15	sah	sah	NOUN
fnp-2615	104	16	)	)	PUNCT
fnp-2615	104	17	.	.	PUNCT
fnp-2615	105	1	a	a	DET
fnp-2615	105	2	recent	recent	ADJ
fnp-2615	105	3	study	study	NOUN
fnp-2615	105	4	showed	show	VERB
fnp-2615	105	5	that	that	SCONJ
fnp-2615	105	6	complement	complement	NOUN
fnp-2615	105	7	components	component	NOUN
fnp-2615	105	8	c1q	c1q	PROPN
fnp-2615	105	9	,	,	PUNCT
fnp-2615	105	10	c3	c3	NOUN
fnp-2615	105	11	/	/	SYM
fnp-2615	105	12	c3b	c3b	PROPN
fnp-2615	105	13	/	/	SYM
fnp-2615	105	14	ic3b	ic3b	PROPN
fnp-2615	105	15	were	be	AUX
fnp-2615	105	16	more	more	ADV
fnp-2615	105	17	abundant	abundant	ADJ
fnp-2615	105	18	in	in	ADP
fnp-2615	105	19	the	the	DET
fnp-2615	105	20	brain	brain	NOUN
fnp-2615	105	21	of	of	ADP
fnp-2615	105	22	sah	sah	NOUN
fnp-2615	105	23	patients	patient	NOUN
fnp-2615	105	24	than	than	ADP
fnp-2615	105	25	controls	control	NOUN
fnp-2615	105	26	(	(	PUNCT
fnp-2615	105	27	van	van	PROPN
fnp-2615	105	28	dijk	dijk	PROPN
fnp-2615	105	29	et	et	PROPN
fnp-2615	105	30	al	al	PROPN
fnp-2615	105	31	.	.	PROPN
fnp-2615	105	32	,	,	PUNCT
fnp-2615	105	33	2019	2019	NUM
fnp-2615	105	34	)	)	PUNCT
fnp-2615	105	35	.	.	PUNCT
fnp-2615	106	1	a	a	DET
fnp-2615	106	2	single	single	ADJ
fnp-2615	106	3	nucleotide	nucleotide	ADJ
fnp-2615	106	4	polymorphism	polymorphism	NOUN
fnp-2615	106	5	in	in	ADP
fnp-2615	106	6	c5	c5	PROPN
fnp-2615	106	7	correlated	correlate	VERB
fnp-2615	106	8	with	with	ADP
fnp-2615	106	9	poor	poor	ADJ
fnp-2615	106	10	outcome	outcome	NOUN
fnp-2615	106	11	in	in	ADP
fnp-2615	106	12	sah	sah	NOUN
fnp-2615	106	13	patients	patient	NOUN
fnp-2615	106	14	,	,	PUNCT
fnp-2615	106	15	which	which	PRON
fnp-2615	106	16	showed	show	VERB
fnp-2615	106	17	increased	increase	VERB
fnp-2615	106	18	levels	level	NOUN
fnp-2615	106	19	of	of	ADP
fnp-2615	106	20	c5a	c5a	NOUN
fnp-2615	106	21	in	in	ADP
fnp-2615	106	22	csf	csf	NOUN
fnp-2615	106	23	and	and	CCONJ
fnp-2615	106	24	plasma	plasma	NOUN
fnp-2615	106	25	.	.	PUNCT
fnp-2615	107	1	in	in	ADP
fnp-2615	107	2	a	a	DET
fnp-2615	107	3	mouse	mouse	NOUN
fnp-2615	107	4	model	model	NOUN
fnp-2615	107	5	of	of	ADP
fnp-2615	107	6	sah	sah	PROPN
fnp-2615	107	7	,	,	PUNCT
fnp-2615	107	8	blocking	block	VERB
fnp-2615	107	9	c5	c5	PROPN
fnp-2615	107	10	activation	activation	NOUN
fnp-2615	107	11	,	,	PUNCT
fnp-2615	107	12	using	use	VERB
fnp-2615	107	13	mice	mouse	NOUN
fnp-2615	107	14	deficient	deficient	ADJ
fnp-2615	107	15	in	in	ADP
fnp-2615	107	16	c5a	c5a	NOUN
fnp-2615	107	17	or	or	CCONJ
fnp-2615	107	18	after	after	ADP
fnp-2615	107	19	administration	administration	NOUN
fnp-2615	107	20	of	of	ADP
fnp-2615	107	21	c5a	c5a	PROPN
fnp-2615	107	22	blocking	blocking	NOUN
fnp-2615	107	23	antibodies	antibody	NOUN
fnp-2615	107	24	,	,	PUNCT
fnp-2615	107	25	reduced	reduce	VERB
fnp-2615	107	26	microglial	microglial	ADJ
fnp-2615	107	27	activation	activation	NOUN
fnp-2615	107	28	and	and	CCONJ
fnp-2615	107	29	neural	neural	ADJ
fnp-2615	107	30	cell	cell	NOUN
fnp-2615	107	31	death	death	NOUN
fnp-2615	107	32	.	.	PUNCT
fnp-2615	108	1	interestingly	interestingly	ADV
fnp-2615	108	2	,	,	PUNCT
fnp-2615	108	3	a	a	DET
fnp-2615	108	4	recent	recent	ADJ
fnp-2615	108	5	study	study	NOUN
fnp-2615	108	6	discovered	discover	VERB
fnp-2615	108	7	molecular	molecular	ADJ
fnp-2615	108	8	links	link	NOUN
fnp-2615	108	9	between	between	ADP
fnp-2615	108	10	complement	complement	NOUN
fnp-2615	108	11	and	and	CCONJ
fnp-2615	108	12	apolipoprotein	apolipoprotein	ADJ
fnp-2615	108	13	-	-	PUNCT
fnp-2615	108	14	e	e	NOUN
fnp-2615	108	15	(	(	PUNCT
fnp-2615	108	16	apoe	apoe	ADJ
fnp-2615	108	17	)	)	PUNCT
fnp-2615	108	18	.	.	PUNCT
fnp-2615	109	1	apoe	apoe	NOUN
fnp-2615	109	2	is	be	AUX
fnp-2615	109	3	a	a	DET
fnp-2615	109	4	factor	factor	NOUN
fnp-2615	109	5	associated	associate	VERB
fnp-2615	109	6	with	with	ADP
fnp-2615	109	7	alzheimer	alzheimer	PROPN
fnp-2615	109	8	’s	’s	PART
fnp-2615	109	9	disease	disease	NOUN
fnp-2615	109	10	,	,	PUNCT
fnp-2615	109	11	cerebrovascular	cerebrovascular	ADJ
fnp-2615	109	12	diseases	disease	NOUN
fnp-2615	109	13	,	,	PUNCT
fnp-2615	109	14	and	and	CCONJ
fnp-2615	109	15	atherosclerosis	atherosclerosis	NOUN
fnp-2615	109	16	(	(	PUNCT
fnp-2615	109	17	yin	yin	NOUN
fnp-2615	109	18	et	et	NOUN
fnp-2615	109	19	al	al	PROPN
fnp-2615	109	20	.	.	PROPN
fnp-2615	109	21	,	,	PUNCT
fnp-2615	109	22	2019	2019	NUM
fnp-2615	109	23	)	)	PUNCT
fnp-2615	109	24	.	.	PUNCT
fnp-2615	110	1	human	human	ADJ
fnp-2615	110	2	apoe	apoe	PROPN
fnp-2615	110	3	has	have	VERB
fnp-2615	110	4	four	four	NUM
fnp-2615	110	5	isoforms	isoform	NOUN
fnp-2615	110	6	apoe	apoe	NOUN
fnp-2615	110	7	,	,	PUNCT
fnp-2615	110	8	apoe2	apoe2	PROPN
fnp-2615	110	9	,	,	PUNCT
fnp-2615	110	10	apoe3	apoe3	PROPN
fnp-2615	110	11	,	,	PUNCT
fnp-2615	110	12	and	and	CCONJ
fnp-2615	110	13	apoe4	apoe4	PROPN
fnp-2615	110	14	.	.	PUNCT
fnp-2615	111	1	the	the	DET
fnp-2615	111	2	apoe4	apoe4	PROPN
fnp-2615	111	3	allele	allele	PROPN
fnp-2615	111	4	is	be	AUX
fnp-2615	111	5	an	an	DET
fnp-2615	111	6	important	important	ADJ
fnp-2615	111	7	risk	risk	NOUN
fnp-2615	111	8	factor	factor	NOUN
fnp-2615	111	9	for	for	ADP
fnp-2615	111	10	late	late	ADJ
fnp-2615	111	11	onset	onset	PROPN
fnp-2615	111	12	alzheimer	alzheimer	PROPN
fnp-2615	111	13	’s	’s	PART
fnp-2615	111	14	disease	disease	NOUN
fnp-2615	111	15	,	,	PUNCT
fnp-2615	111	16	whereas	whereas	SCONJ
fnp-2615	111	17	several	several	ADJ
fnp-2615	111	18	studies	study	NOUN
fnp-2615	111	19	indicate	indicate	VERB
fnp-2615	111	20	that	that	SCONJ
fnp-2615	111	21	altered	alter	VERB
fnp-2615	111	22	apoe2	apoe2	NOUN
fnp-2615	111	23	could	could	AUX
fnp-2615	111	24	be	be	AUX
fnp-2615	111	25	associated	associate	VERB
fnp-2615	111	26	with	with	ADP
fnp-2615	111	27	white	white	ADJ
fnp-2615	111	28	matter	matter	NOUN
fnp-2615	111	29	hyperintensities	hyperintensitie	NOUN
fnp-2615	111	30	in	in	ADP
fnp-2615	111	31	small	small	ADJ
fnp-2615	111	32	vessel	vessel	NOUN
fnp-2615	111	33	diseases	disease	NOUN
fnp-2615	111	34	.	.	PUNCT
fnp-2615	112	1	yin	yin	PROPN
fnp-2615	112	2	et	et	PROPN
fnp-2615	112	3	al	al	PROPN
fnp-2615	112	4	.	.	PROPN
fnp-2615	113	1	(	(	PUNCT
fnp-2615	113	2	2019	2019	NUM
fnp-2615	113	3	)	)	PUNCT
fnp-2615	113	4	showed	show	VERB
fnp-2615	113	5	absence	absence	NOUN
fnp-2615	113	6	of	of	ADP
fnp-2615	113	7	apoe	apoe	NOUN
fnp-2615	113	8	-	-	PUNCT
fnp-2615	113	9	mediated	mediate	VERB
fnp-2615	113	10	activation	activation	NOUN
fnp-2615	113	11	of	of	ADP
fnp-2615	113	12	the	the	DET
fnp-2615	113	13	classical	classical	ADJ
fnp-2615	113	14	complement	complement	NOUN
fnp-2615	113	15	cascade	cascade	NOUN
fnp-2615	113	16	in	in	ADP
fnp-2615	113	17	the	the	DET
fnp-2615	113	18	choroid	choroid	NOUN
fnp-2615	113	19	plexus	plexus	NOUN
fnp-2615	113	20	.	.	PUNCT
fnp-2615	114	1	lipid	lipid	NOUN
fnp-2615	114	2	deposits	deposit	NOUN
fnp-2615	114	3	were	be	AUX
fnp-2615	114	4	noticed	notice	VERB
fnp-2615	114	5	in	in	ADP
fnp-2615	114	6	choroid	choroid	NOUN
fnp-2615	114	7	plexus	plexus	NOUN
fnp-2615	114	8	of	of	ADP
fnp-2615	114	9	aged	aged	ADJ
fnp-2615	114	10	apoe-/mice	apoe-/mice	NOUN
fnp-2615	114	11	regardless	regardless	ADV
fnp-2615	114	12	of	of	ADP
fnp-2615	114	13	whether	whether	SCONJ
fnp-2615	114	14	they	they	PRON
fnp-2615	114	15	were	be	AUX
fnp-2615	114	16	fed	feed	VERB
fnp-2615	114	17	a	a	DET
fnp-2615	114	18	high	high	ADJ
fnp-2615	114	19	fat	fat	ADJ
fnp-2615	114	20	diet	diet	NOUN
fnp-2615	114	21	or	or	CCONJ
fnp-2615	114	22	normal	normal	ADJ
fnp-2615	114	23	chow	chow	NOUN
fnp-2615	114	24	.	.	PUNCT
fnp-2615	115	1	knockin	knockin	NOUN
fnp-2615	115	2	mice	mouse	NOUN
fnp-2615	115	3	expressing	express	VERB
fnp-2615	115	4	the	the	DET
fnp-2615	115	5	human	human	ADJ
fnp-2615	115	6	form	form	NOUN
fnp-2615	115	7	of	of	ADP
fnp-2615	115	8	apoe4	apoe4	PROPN
fnp-2615	115	9	(	(	PUNCT
fnp-2615	115	10	apoe4	apoe4	PROPN
fnp-2615	115	11	-	-	PUNCT
fnp-2615	115	12	ki	ki	PROPN
fnp-2615	115	13	)	)	PUNCT
fnp-2615	115	14	also	also	ADV
fnp-2615	115	15	showed	show	VERB
fnp-2615	115	16	lipid	lipid	NOUN
fnp-2615	115	17	deposits	deposit	NOUN
fnp-2615	115	18	in	in	ADP
fnp-2615	115	19	the	the	DET
fnp-2615	115	20	choroid	choroid	NOUN
fnp-2615	115	21	plexus	plexus	NOUN
fnp-2615	115	22	but	but	CCONJ
fnp-2615	115	23	only	only	ADV
fnp-2615	115	24	when	when	SCONJ
fnp-2615	115	25	fed	fed	PROPN
fnp-2615	115	26	a	a	DET
fnp-2615	115	27	high	high	ADJ
fnp-2615	115	28	fat	fat	ADJ
fnp-2615	115	29	diet	diet	NOUN
fnp-2615	115	30	.	.	PUNCT
fnp-2615	116	1	in	in	ADP
fnp-2615	116	2	contrast	contrast	NOUN
fnp-2615	116	3	,	,	PUNCT
fnp-2615	116	4	apoe3	apoe3	PROPN
fnp-2615	116	5	-	-	PUNCT
fnp-2615	116	6	ki	ki	PROPN
fnp-2615	116	7	mice	mouse	NOUN
fnp-2615	116	8	did	do	AUX
fnp-2615	116	9	not	not	PART
fnp-2615	116	10	develop	develop	VERB
fnp-2615	116	11	those	those	DET
fnp-2615	116	12	lipid	lipid	NOUN
fnp-2615	116	13	deposits	deposit	NOUN
fnp-2615	116	14	irrespective	irrespective	ADV
fnp-2615	116	15	of	of	ADP
fnp-2615	116	16	diet	diet	NOUN
fnp-2615	116	17	regimen	regiman	NOUN
fnp-2615	116	18	.	.	PUNCT
fnp-2615	117	1	lipid	lipid	ADJ
fnp-2615	117	2	accumulation	accumulation	NOUN
fnp-2615	117	3	was	be	AUX
fnp-2615	117	4	paralleled	parallel	VERB
fnp-2615	117	5	by	by	ADP
fnp-2615	117	6	leukocyte	leukocyte	ADJ
fnp-2615	117	7	accumulation	accumulation	NOUN
fnp-2615	117	8	in	in	ADP
fnp-2615	117	9	the	the	DET
fnp-2615	117	10	choroid	choroid	NOUN
fnp-2615	117	11	plexus	plexus	NOUN
fnp-2615	117	12	and	and	CCONJ
fnp-2615	117	13	csf	csf	PROPN
fnp-2615	117	14	.	.	PUNCT
fnp-2615	118	1	using	use	VERB
fnp-2615	118	2	laser	laser	NOUN
fnp-2615	118	3	-	-	PUNCT
fnp-2615	118	4	capture	capture	NOUN
fnp-2615	118	5	microdissection	microdissection	NOUN
fnp-2615	118	6	of	of	ADP
fnp-2615	118	7	choroid	choroid	NOUN
fnp-2615	118	8	plexus	plexus	NOUN
fnp-2615	118	9	followed	follow	VERB
fnp-2615	118	10	by	by	ADP
fnp-2615	118	11	differential	differential	ADJ
fnp-2615	118	12	gene	gene	NOUN
fnp-2615	118	13	expression	expression	NOUN
fnp-2615	118	14	profiling	profiling	NOUN
fnp-2615	118	15	,	,	PUNCT
fnp-2615	118	16	an	an	DET
fnp-2615	118	17	interferon	interferon	ADJ
fnp-2615	118	18	signature	signature	NOUN
fnp-2615	118	19	was	be	AUX
fnp-2615	118	20	detected	detect	VERB
fnp-2615	118	21	in	in	ADP
fnp-2615	118	22	apoe4	apoe4	PROPN
fnp-2615	118	23	-	-	PUNCT
fnp-2615	118	24	ki	ki	PROPN
fnp-2615	118	25	mice	mouse	NOUN
fnp-2615	118	26	.	.	PUNCT
fnp-2615	119	1	additionally	additionally	ADV
fnp-2615	119	2	,	,	PUNCT
fnp-2615	119	3	upregulation	upregulation	NOUN
fnp-2615	119	4	of	of	ADP
fnp-2615	119	5	complement	complement	NOUN
fnp-2615	119	6	genes	gene	NOUN
fnp-2615	119	7	was	be	AUX
fnp-2615	119	8	detected	detect	VERB
fnp-2615	119	9	in	in	ADP
fnp-2615	119	10	apoe-/mice	apoe-/mice	X
fnp-2615	119	11	.	.	PUNCT
fnp-2615	120	1	accordingly	accordingly	ADV
fnp-2615	120	2	,	,	PUNCT
fnp-2615	120	3	the	the	DET
fnp-2615	120	4	choroid	choroid	NOUN
fnp-2615	120	5	plexus	plexus	NOUN
fnp-2615	120	6	of	of	ADP
fnp-2615	120	7	apoe-/mice	apoe-/mice	NOUN
fnp-2615	120	8	showed	show	VERB
fnp-2615	120	9	accumulation	accumulation	NOUN
fnp-2615	120	10	of	of	ADP
fnp-2615	120	11	immunoglobulins	immunoglobulin	NOUN
fnp-2615	120	12	,	,	PUNCT
fnp-2615	120	13	and	and	CCONJ
fnp-2615	120	14	complement	complement	VERB
fnp-2615	120	15	proteins	protein	NOUN
fnp-2615	120	16	c1q	c1q	ADP
fnp-2615	120	17	,	,	PUNCT
fnp-2615	120	18	c3	c3	NOUN
fnp-2615	120	19	,	,	PUNCT
fnp-2615	120	20	c4	c4	NOUN
fnp-2615	120	21	,	,	PUNCT
fnp-2615	120	22	as	as	ADV
fnp-2615	120	23	well	well	ADV
fnp-2615	120	24	as	as	ADP
fnp-2615	120	25	c5	c5	PROPN
fnp-2615	120	26	and	and	CCONJ
fnp-2615	120	27	anaphylatoxin	anaphylatoxin	PROPN
fnp-2615	120	28	c3a	c3a	PROPN
fnp-2615	120	29	.	.	PROPN
fnp-2615	120	30	through	through	ADP
fnp-2615	120	31	various	various	ADJ
fnp-2615	120	32	in	in	ADP
fnp-2615	120	33	vitro	vitro	X
fnp-2615	120	34	strategies	strategy	NOUN
fnp-2615	120	35	,	,	PUNCT
fnp-2615	120	36	the	the	DET
fnp-2615	120	37	study	study	NOUN
fnp-2615	120	38	demonstrated	demonstrate	VERB
fnp-2615	120	39	that	that	SCONJ
fnp-2615	120	40	apoe	apoe	NOUN
fnp-2615	120	41	inhibits	inhibit	VERB
fnp-2615	120	42	the	the	DET
fnp-2615	120	43	classical	classical	ADJ
fnp-2615	120	44	pathway	pathway	NOUN
fnp-2615	120	45	of	of	ADP
fnp-2615	120	46	complement	complement	NOUN
fnp-2615	120	47	activation	activation	NOUN
fnp-2615	120	48	through	through	ADP
fnp-2615	120	49	ca2	ca2	PROPN
fnp-2615	120	50	+	+	PROPN
fnp-2615	120	51	-dependent	-dependent	ADJ
fnp-2615	120	52	high	high	ADJ
fnp-2615	120	53	affinity	affinity	NOUN
fnp-2615	120	54	binding	bind	VERB
fnp-2615	120	55	to	to	ADP
fnp-2615	120	56	the	the	DET
fnp-2615	120	57	activated	activate	VERB
fnp-2615	120	58	form	form	NOUN
fnp-2615	120	59	of	of	ADP
fnp-2615	120	60	c1q	c1q	PROPN
fnp-2615	120	61	,	,	PUNCT
fnp-2615	120	62	which	which	PRON
fnp-2615	120	63	was	be	AUX
fnp-2615	120	64	elicited	elicit	VERB
fnp-2615	120	65	by	by	ADP
fnp-2615	120	66	all	all	DET
fnp-2615	120	67	apoe	apoe	ADJ
fnp-2615	120	68	isoforms	isoform	NOUN
fnp-2615	120	69	.	.	PUNCT
fnp-2615	121	1	notably	notably	ADV
fnp-2615	121	2	,	,	PUNCT
fnp-2615	121	3	the	the	DET
fnp-2615	121	4	formation	formation	NOUN
fnp-2615	121	5	of	of	ADP
fnp-2615	121	6	lipid	lipid	NOUN
fnp-2615	121	7	droplets	droplet	NOUN
fnp-2615	121	8	in	in	ADP
fnp-2615	121	9	the	the	DET
fnp-2615	121	10	choroid	choroid	NOUN
fnp-2615	121	11	plexus	plexus	NOUN
fnp-2615	121	12	was	be	AUX
fnp-2615	121	13	found	find	VERB
fnp-2615	121	14	in	in	ADP
fnp-2615	121	15	human	human	ADJ
fnp-2615	121	16	brains	brain	NOUN
fnp-2615	121	17	with	with	ADP
fnp-2615	121	18	various	various	ADJ
fnp-2615	121	19	degrees	degree	NOUN
fnp-2615	121	20	of	of	ADP
fnp-2615	121	21	alzheimer	alzheimer	PROPN
fnp-2615	121	22	’s	’s	PART
fnp-2615	121	23	disease	disease	NOUN
fnp-2615	121	24	pathology	pathology	NOUN
fnp-2615	121	25	,	,	PUNCT
fnp-2615	121	26	and	and	CCONJ
fnp-2615	121	27	higher	high	ADJ
fnp-2615	121	28	lipid	lipid	ADJ
fnp-2615	121	29	droplet	droplet	ADJ
fnp-2615	121	30	numbers	number	NOUN
fnp-2615	121	31	were	be	AUX
fnp-2615	121	32	found	find	VERB
fnp-2615	121	33	in	in	ADP
fnp-2615	121	34	patients	patient	NOUN
fnp-2615	121	35	with	with	ADP
fnp-2615	121	36	dementia	dementia	NOUN
fnp-2615	121	37	.	.	PUNCT
fnp-2615	122	1	lipid	lipid	NOUN
fnp-2615	122	2	deposits	deposit	NOUN
fnp-2615	122	3	were	be	AUX
fnp-2615	122	4	associated	associate	VERB
fnp-2615	122	5	with	with	ADP
fnp-2615	122	6	c1q	c1q	NOUN
fnp-2615	122	7	-	-	PUNCT
fnp-2615	122	8	apoe	apoe	ADJ
fnp-2615	122	9	complex	complex	NOUN
fnp-2615	122	10	.	.	PUNCT
fnp-2615	123	1	furthermore	furthermore	ADV
fnp-2615	123	2	,	,	PUNCT
fnp-2615	123	3	c1q	c1q	ADV
fnp-2615	123	4	and	and	CCONJ
fnp-2615	123	5	apoe	apoe	ADV
fnp-2615	123	6	colocalized	colocalize	VERB
fnp-2615	123	7	in	in	ADP
fnp-2615	123	8	atherosclerotic	atherosclerotic	ADJ
fnp-2615	123	9	plaques	plaque	NOUN
fnp-2615	123	10	.	.	PUNCT
fnp-2615	124	1	overall	overall	ADV
fnp-2615	124	2	,	,	PUNCT
fnp-2615	124	3	the	the	DET
fnp-2615	124	4	study	study	NOUN
fnp-2615	124	5	suggests	suggest	VERB
fnp-2615	124	6	that	that	SCONJ
fnp-2615	124	7	apoe	apoe	NOUN
fnp-2615	124	8	may	may	AUX
fnp-2615	124	9	prevent	prevent	VERB
fnp-2615	124	10	complement	complement	NOUN
fnp-2615	124	11	activation	activation	NOUN
fnp-2615	124	12	.	.	PUNCT
fnp-2615	125	1	altered	alter	VERB
fnp-2615	125	2	inhibitory	inhibitory	ADJ
fnp-2615	125	3	effects	effect	NOUN
fnp-2615	125	4	of	of	ADP
fnp-2615	125	5	apoe	apoe	NOUN
fnp-2615	125	6	on	on	ADP
fnp-2615	125	7	complement	complement	NOUN
fnp-2615	125	8	due	due	ADP
fnp-2615	125	9	to	to	ADP
fnp-2615	125	10	allelic	allelic	ADJ
fnp-2615	125	11	alterations	alteration	NOUN
fnp-2615	125	12	is	be	AUX
fnp-2615	125	13	proposed	propose	VERB
fnp-2615	125	14	as	as	ADP
fnp-2615	125	15	a	a	DET
fnp-2615	125	16	pathogenic	pathogenic	ADJ
fnp-2615	125	17	mechanism	mechanism	NOUN
fnp-2615	125	18	in	in	ADP
fnp-2615	125	19	alzheimer	alzheimer	PROPN
fnp-2615	125	20	’s	’s	PART
fnp-2615	125	21	disease	disease	NOUN
fnp-2615	125	22	and	and	CCONJ
fnp-2615	125	23	atherosclerosis	atherosclerosis	NOUN
fnp-2615	125	24	.	.	PUNCT
fnp-2615	126	1	further	further	ADJ
fnp-2615	126	2	studies	study	NOUN
fnp-2615	126	3	will	will	AUX
fnp-2615	126	4	hopefully	hopefully	ADV
fnp-2615	126	5	elucidate	elucidate	VERB
fnp-2615	126	6	the	the	DET
fnp-2615	126	7	role	role	NOUN
fnp-2615	126	8	of	of	ADP
fnp-2615	126	9	this	this	DET
fnp-2615	126	10	new	new	ADJ
fnp-2615	126	11	molecular	molecular	ADJ
fnp-2615	126	12	interaction	interaction	NOUN
fnp-2615	126	13	between	between	ADP
fnp-2615	126	14	apoe	apoe	NOUN
fnp-2615	126	15	and	and	CCONJ
fnp-2615	126	16	complement	complement	VERB
fnp-2615	126	17	in	in	ADP
fnp-2615	126	18	cerebrovascular	cerebrovascular	ADJ
fnp-2615	126	19	and	and	CCONJ
fnp-2615	126	20	neurodegenerative	neurodegenerative	ADJ
fnp-2615	126	21	diseases	disease	NOUN
fnp-2615	126	22	.	.	PUNCT
fnp-2615	127	1	5	5	X
fnp-2615	127	2	.	.	X
fnp-2615	127	3	cerebral	cerebral	ADJ
fnp-2615	127	4	amyloid	amyloid	NOUN
fnp-2615	127	5	angiopathy	angiopathy	NOUN
fnp-2615	127	6	:	:	PUNCT
fnp-2615	127	7	microbleeds	microbleed	NOUN
fnp-2615	127	8	,	,	PUNCT
fnp-2615	127	9	microinfarcts	microinfarct	NOUN
fnp-2615	127	10	and	and	CCONJ
fnp-2615	127	11	white	white	ADJ
fnp-2615	127	12	matter	matter	NOUN
fnp-2615	127	13	hyperintensities	hyperintensitie	NOUN
fnp-2615	127	14	progress	progress	NOUN
fnp-2615	127	15	has	have	AUX
fnp-2615	127	16	been	be	AUX
fnp-2615	127	17	made	make	VERB
fnp-2615	127	18	in	in	ADP
fnp-2615	127	19	understanding	understand	VERB
fnp-2615	127	20	the	the	DET
fnp-2615	127	21	neuropathology	neuropathology	NOUN
fnp-2615	127	22	of	of	ADP
fnp-2615	127	23	caa	caa	PROPN
fnp-2615	127	24	as	as	ADV
fnp-2615	127	25	well	well	ADV
fnp-2615	127	26	as	as	ADP
fnp-2615	127	27	the	the	DET
fnp-2615	127	28	neuropathological	neuropathological	ADJ
fnp-2615	127	29	correlates	correlate	VERB
fnp-2615	127	30	of	of	ADP
fnp-2615	127	31	mri	mri	NOUN
fnp-2615	127	32	alterations	alteration	NOUN
fnp-2615	127	33	in	in	ADP
fnp-2615	127	34	this	this	DET
fnp-2615	127	35	condition	condition	NOUN
fnp-2615	127	36	.	.	PUNCT
fnp-2615	128	1	caa	caa	PROPN
fnp-2615	128	2	can	can	AUX
fnp-2615	128	3	lead	lead	VERB
fnp-2615	128	4	to	to	ADP
fnp-2615	128	5	symptomatic	symptomatic	ADJ
fnp-2615	128	6	lobar	lobar	ADJ
fnp-2615	128	7	intracerebral	intracerebral	ADJ
fnp-2615	128	8	hemorrhage	hemorrhage	NOUN
fnp-2615	128	9	.	.	PUNCT
fnp-2615	129	1	mri	mri	NOUN
fnp-2615	129	2	of	of	ADP
fnp-2615	129	3	caa	caa	NOUN
fnp-2615	129	4	patients	patient	NOUN
fnp-2615	129	5	may	may	AUX
fnp-2615	129	6	show	show	VERB
fnp-2615	129	7	microbleeds	microbleed	NOUN
fnp-2615	129	8	,	,	PUNCT
fnp-2615	129	9	microinfarcts	microinfarct	NOUN
fnp-2615	129	10	,	,	PUNCT
fnp-2615	129	11	and	and	CCONJ
fnp-2615	129	12	white	white	ADJ
fnp-2615	129	13	matter	matter	NOUN
fnp-2615	129	14	hyperintensities	hyperintensitie	NOUN
fnp-2615	129	15	(	(	PUNCT
fnp-2615	129	16	reijmer	reijmer	PROPN
fnp-2615	129	17	et	et	PROPN
fnp-2615	129	18	al	al	PROPN
fnp-2615	129	19	.	.	PROPN
fnp-2615	129	20	,	,	PUNCT
fnp-2615	129	21	2015	2015	NUM
fnp-2615	129	22	)	)	PUNCT
fnp-2615	129	23	.	.	PUNCT
fnp-2615	130	1	van	van	PROPN
fnp-2615	130	2	veluw	veluw	PROPN
fnp-2615	130	3	et	et	PROPN
fnp-2615	130	4	al	al	PROPN
fnp-2615	130	5	.	.	PUNCT
fnp-2615	130	6	(	(	PUNCT
fnp-2615	130	7	2019a	2019a	NUM
fnp-2615	130	8	)	)	PUNCT
fnp-2615	130	9	reported	report	VERB
fnp-2615	130	10	that	that	SCONJ
fnp-2615	130	11	microbleeds	microbleed	NOUN
fnp-2615	130	12	and	and	CCONJ
fnp-2615	130	13	microinfarcts	microinfarct	NOUN
fnp-2615	130	14	represent	represent	VERB
fnp-2615	130	15	different	different	ADJ
fnp-2615	130	16	microvascular	microvascular	NOUN
fnp-2615	130	17	alterations	alteration	NOUN
fnp-2615	130	18	in	in	ADP
fnp-2615	130	19	caa	caa	NOUN
fnp-2615	130	20	.	.	PUNCT
fnp-2615	131	1	the	the	DET
fnp-2615	131	2	vessels	vessel	NOUN
fnp-2615	131	3	showing	show	VERB
fnp-2615	131	4	microbleeds	microbleed	NOUN
fnp-2615	131	5	had	have	VERB
fnp-2615	131	6	accumulation	accumulation	NOUN
fnp-2615	131	7	of	of	ADP
fnp-2615	131	8	amyloid	amyloid	NOUN
fnp-2615	131	9	β	β	X
fnp-2615	131	10	(	(	PUNCT
fnp-2615	131	11	aβ	aβ	NOUN
fnp-2615	131	12	)	)	PUNCT
fnp-2615	131	13	and	and	CCONJ
fnp-2615	131	14	fibrin	fibrin	NOUN
fnp-2615	131	15	/	/	SYM
fnp-2615	131	16	fibrinogen	fibrinogen	NOUN
fnp-2615	131	17	upstream	upstream	NOUN
fnp-2615	131	18	and	and	CCONJ
fnp-2615	131	19	downstream	downstream	NOUN
fnp-2615	131	20	of	of	ADP
fnp-2615	131	21	the	the	DET
fnp-2615	131	22	microbleed	microbleed	NOUN
fnp-2615	131	23	,	,	PUNCT
fnp-2615	131	24	but	but	CCONJ
fnp-2615	131	25	not	not	PART
fnp-2615	131	26	in	in	ADP
fnp-2615	131	27	the	the	DET
fnp-2615	131	28	microbleed	microbleed	ADJ
fnp-2615	131	29	region	region	NOUN
fnp-2615	131	30	devoid	devoid	ADJ
fnp-2615	131	31	of	of	ADP
fnp-2615	131	32	smooth	smooth	ADJ
fnp-2615	131	33	muscle	muscle	NOUN
fnp-2615	131	34	cells	cell	NOUN
fnp-2615	131	35	(	(	PUNCT
fnp-2615	131	36	smcs	smcs	ADJ
fnp-2615	131	37	)	)	PUNCT
fnp-2615	131	38	.	.	PUNCT
fnp-2615	132	1	likewise	likewise	ADV
fnp-2615	132	2	,	,	PUNCT
fnp-2615	132	3	smcs	smcs	PROPN
fnp-2615	132	4	were	be	AUX
fnp-2615	132	5	missing	miss	VERB
fnp-2615	132	6	in	in	ADP
fnp-2615	132	7	the	the	DET
fnp-2615	132	8	regions	region	NOUN
fnp-2615	132	9	of	of	ADP
fnp-2615	132	10	microinfarcts	microinfarct	NOUN
fnp-2615	132	11	,	,	PUNCT
fnp-2615	132	12	but	but	CCONJ
fnp-2615	132	13	in	in	ADP
fnp-2615	132	14	this	this	DET
fnp-2615	132	15	case	case	NOUN
fnp-2615	132	16	aβ	aβ	NOUN
fnp-2615	132	17	was	be	AUX
fnp-2615	132	18	present	present	ADJ
fnp-2615	132	19	in	in	ADP
fnp-2615	132	20	the	the	DET
fnp-2615	132	21	injured	injure	VERB
fnp-2615	132	22	core	core	NOUN
fnp-2615	132	23	.	.	PUNCT
fnp-2615	133	1	the	the	DET
fnp-2615	133	2	study	study	NOUN
fnp-2615	133	3	suggested	suggest	VERB
fnp-2615	133	4	that	that	SCONJ
fnp-2615	133	5	removal	removal	NOUN
fnp-2615	133	6	of	of	ADP
fnp-2615	133	7	aβ	aβ	PRON
fnp-2615	133	8	in	in	ADP
fnp-2615	133	9	vessels	vessel	NOUN
fnp-2615	133	10	that	that	PRON
fnp-2615	133	11	have	have	AUX
fnp-2615	133	12	lost	lose	VERB
fnp-2615	133	13	smcs	smcs	ADJ
fnp-2615	133	14	might	might	AUX
fnp-2615	133	15	increase	increase	VERB
fnp-2615	133	16	the	the	DET
fnp-2615	133	17	risk	risk	NOUN
fnp-2615	133	18	of	of	ADP
fnp-2615	133	19	bleeding	bleeding	NOUN
fnp-2615	133	20	,	,	PUNCT
fnp-2615	133	21	which	which	PRON
fnp-2615	133	22	,	,	PUNCT
fnp-2615	133	23	if	if	SCONJ
fnp-2615	133	24	confirmed	confirm	VERB
fnp-2615	133	25	,	,	PUNCT
fnp-2615	133	26	might	might	AUX
fnp-2615	133	27	potentially	potentially	ADV
fnp-2615	133	28	have	have	VERB
fnp-2615	133	29	future	future	ADJ
fnp-2615	133	30	therapeutic	therapeutic	ADJ
fnp-2615	133	31	implications	implication	NOUN
fnp-2615	133	32	.	.	PUNCT
fnp-2615	134	1	using	use	VERB
fnp-2615	134	2	high	high	ADJ
fnp-2615	134	3	resolution	resolution	NOUN
fnp-2615	134	4	mri	mri	NOUN
fnp-2615	134	5	in	in	ADP
fnp-2615	134	6	post	post	ADJ
fnp-2615	134	7	-	-	ADJ
fnp-2615	134	8	mortem	mortem	ADJ
fnp-2615	134	9	brain	brain	NOUN
fnp-2615	134	10	tissue	tissue	NOUN
fnp-2615	134	11	with	with	ADP
fnp-2615	134	12	correlative	correlative	ADJ
fnp-2615	134	13	histopathological	histopathological	ADJ
fnp-2615	134	14	analyses	analysis	NOUN
fnp-2615	134	15	,	,	PUNCT
fnp-2615	134	16	van	van	PROPN
fnp-2615	134	17	veluw	veluw	NOUN
fnp-2615	134	18	et	et	PROPN
fnp-2615	134	19	al	al	PROPN
fnp-2615	134	20	(	(	PUNCT
fnp-2615	134	21	2019b	2019b	NUM
fnp-2615	134	22	)	)	PUNCT
fnp-2615	134	23	provided	provide	VERB
fnp-2615	134	24	relevant	relevant	ADJ
fnp-2615	134	25	information	information	NOUN
fnp-2615	134	26	on	on	ADP
fnp-2615	134	27	the	the	DET
fnp-2615	134	28	neuropathological	neuropathological	ADJ
fnp-2615	134	29	correlates	correlate	NOUN
fnp-2615	134	30	of	of	ADP
fnp-2615	134	31	neuroimaging	neuroimage	VERB
fnp-2615	134	32	alterations	alteration	NOUN
fnp-2615	134	33	.	.	PUNCT
fnp-2615	135	1	diffusion	diffusion	NOUN
fnp-2615	135	2	tensor	tensor	NOUN
fnp-2615	135	3	imaging	imaging	NOUN
fnp-2615	135	4	(	(	PUNCT
fnp-2615	135	5	dti	dti	PROPN
fnp-2615	135	6	)	)	PUNCT
fnp-2615	135	7	is	be	AUX
fnp-2615	135	8	the	the	DET
fnp-2615	135	9	mri	mri	NOUN
fnp-2615	135	10	modality	modality	NOUN
fnp-2615	135	11	best	well	ADV
fnp-2615	135	12	suited	suit	VERB
fnp-2615	135	13	to	to	PART
fnp-2615	135	14	study	study	VERB
fnp-2615	135	15	white	white	ADJ
fnp-2615	135	16	matter	matter	NOUN
fnp-2615	135	17	fiber	fiber	NOUN
fnp-2615	135	18	track	track	NOUN
fnp-2615	135	19	orientation	orientation	NOUN
fnp-2615	135	20	and	and	CCONJ
fnp-2615	135	21	physical	physical	ADJ
fnp-2615	135	22	features	feature	NOUN
fnp-2615	135	23	that	that	PRON
fnp-2615	135	24	can	can	AUX
fnp-2615	135	25	assess	assess	VERB
fnp-2615	135	26	microstructural	microstructural	ADJ
fnp-2615	135	27	integrity	integrity	NOUN
fnp-2615	135	28	of	of	ADP
fnp-2615	135	29	the	the	DET
fnp-2615	135	30	brain	brain	NOUN
fnp-2615	135	31	tissue	tissue	NOUN
fnp-2615	135	32	.	.	PUNCT
fnp-2615	136	1	the	the	DET
fnp-2615	136	2	post	post	ADJ
fnp-2615	136	3	-	-	ADJ
fnp-2615	136	4	mortem	mortem	ADJ
fnp-2615	136	5	brain	brain	NOUN
fnp-2615	136	6	of	of	ADP
fnp-2615	136	7	caa	caa	NOUN
fnp-2615	136	8	patients	patient	NOUN
fnp-2615	136	9	was	be	AUX
fnp-2615	136	10	fixed	fix	VERB
fnp-2615	136	11	with	with	ADP
fnp-2615	136	12	10	10	NUM
fnp-2615	136	13	%	%	NOUN
fnp-2615	136	14	formalin	formalin	NOUN
fnp-2615	136	15	for	for	ADP
fnp-2615	136	16	at	at	ADV
fnp-2615	136	17	least	least	ADV
fnp-2615	136	18	3	3	NUM
fnp-2615	136	19	weeks	week	NOUN
fnp-2615	136	20	.	.	PUNCT
fnp-2615	137	1	one	one	NUM
fnp-2615	137	2	brain	brain	NOUN
fnp-2615	137	3	hemisphere	hemisphere	ADV
fnp-2615	137	4	was	be	AUX
fnp-2615	137	5	scanned	scan	VERB
fnp-2615	137	6	in	in	ADP
fnp-2615	137	7	a	a	DET
fnp-2615	137	8	3	3	NUM
fnp-2615	137	9	t	t	NOUN
fnp-2615	137	10	mri	mri	NOUN
fnp-2615	137	11	scanner	scanner	NOUN
fnp-2615	137	12	for	for	ADP
fnp-2615	137	13	14	14	NUM
fnp-2615	137	14	hours	hour	NOUN
fnp-2615	137	15	.	.	PUNCT
fnp-2615	138	1	image	image	NOUN
fnp-2615	138	2	analysis	analysis	NOUN
fnp-2615	138	3	included	include	VERB
fnp-2615	138	4	fiber	fiber	NOUN
fnp-2615	138	5	tractography	tractography	NOUN
fnp-2615	138	6	,	,	PUNCT
fnp-2615	138	7	and	and	CCONJ
fnp-2615	138	8	3	3	NUM
fnp-2615	138	9	-	-	PUNCT
fnp-2615	138	10	mm	mm	NUM
fnp-2615	138	11	thick	thick	ADJ
fnp-2615	138	12	regions	region	NOUN
fnp-2615	138	13	of	of	ADP
fnp-2615	138	14	interest	interest	NOUN
fnp-2615	138	15	were	be	AUX
fnp-2615	138	16	highlighted	highlight	VERB
fnp-2615	138	17	in	in	ADP
fnp-2615	138	18	parts	part	NOUN
fnp-2615	138	19	of	of	ADP
fnp-2615	138	20	the	the	DET
fnp-2615	138	21	tracts	tract	NOUN
fnp-2615	138	22	later	later	ADV
fnp-2615	138	23	taken	take	VERB
fnp-2615	138	24	for	for	ADP
fnp-2615	138	25	histology	histology	NOUN
fnp-2615	138	26	.	.	PUNCT
fnp-2615	139	1	formalin	formalin	NOUN
fnp-2615	139	2	fixation	fixation	NOUN
fnp-2615	139	3	alters	alter	VERB
fnp-2615	139	4	the	the	DET
fnp-2615	139	5	mri	mri	NOUN
fnp-2615	139	6	diffusion	diffusion	NOUN
fnp-2615	139	7	properties	property	NOUN
fnp-2615	139	8	,	,	PUNCT
fnp-2615	139	9	but	but	CCONJ
fnp-2615	139	10	fractional	fractional	ADJ
fnp-2615	139	11	anisotropy	anisotropy	NOUN
fnp-2615	139	12	measured	measure	VERB
fnp-2615	139	13	in	in	ADP
fnp-2615	139	14	vivo	vivo	NOUN
fnp-2615	139	15	was	be	AUX
fnp-2615	139	16	linearly	linearly	ADV
fnp-2615	139	17	related	relate	VERB
fnp-2615	139	18	with	with	ADP
fnp-2615	139	19	fractional	fractional	ADJ
fnp-2615	139	20	anisotropy	anisotropy	NOUN
fnp-2615	139	21	acquired	acquire	VERB
fnp-2615	139	22	ex	ex	PRON
fnp-2615	139	23	vivo	vivo	NOUN
fnp-2615	139	24	in	in	ADP
fnp-2615	139	25	the	the	DET
fnp-2615	139	26	same	same	ADJ
fnp-2615	139	27	brains	brain	NOUN
fnp-2615	139	28	.	.	PUNCT
fnp-2615	140	1	the	the	DET
fnp-2615	140	2	tissue	tissue	NOUN
fnp-2615	140	3	was	be	AUX
fnp-2615	140	4	embedded	embed	VERB
fnp-2615	140	5	in	in	ADP
fnp-2615	140	6	paraffin	paraffin	NOUN
fnp-2615	140	7	and	and	CCONJ
fnp-2615	140	8	6-µm	6-µm	NUM
fnp-2615	140	9	thick	thick	ADJ
fnp-2615	140	10	sections	section	NOUN
fnp-2615	140	11	were	be	AUX
fnp-2615	140	12	obtained	obtain	VERB
fnp-2615	140	13	for	for	ADP
fnp-2615	140	14	histological	histological	ADJ
fnp-2615	140	15	analyses	analysis	NOUN
fnp-2615	140	16	.	.	PUNCT
fnp-2615	141	1	the	the	DET
fnp-2615	141	2	studies	study	NOUN
fnp-2615	141	3	found	find	VERB
fnp-2615	141	4	reduced	reduce	VERB
fnp-2615	141	5	fractional	fractional	ADJ
fnp-2615	141	6	anisotropy	anisotropy	NOUN
fnp-2615	141	7	in	in	ADP
fnp-2615	141	8	caa	caa	NOUN
fnp-2615	141	9	patients	patient	NOUN
fnp-2615	141	10	compared	compare	VERB
fnp-2615	141	11	to	to	ADP
fnp-2615	141	12	controls	control	NOUN
fnp-2615	141	13	.	.	PUNCT
fnp-2615	142	1	in	in	ADP
fnp-2615	142	2	multivariate	multivariate	NOUN
fnp-2615	142	3	analysis	analysis	NOUN
fnp-2615	142	4	,	,	PUNCT
fnp-2615	142	5	fractional	fractional	ADJ
fnp-2615	142	6	anisotropy	anisotropy	NOUN
fnp-2615	142	7	data	datum	NOUN
fnp-2615	142	8	was	be	AUX
fnp-2615	142	9	independently	independently	ADV
fnp-2615	142	10	associated	associate	VERB
fnp-2615	142	11	with	with	ADP
fnp-2615	142	12	tissue	tissue	NOUN
fnp-2615	142	13	rarefaction	rarefaction	NOUN
fnp-2615	142	14	as	as	SCONJ
fnp-2615	142	15	assessed	assess	VERB
fnp-2615	142	16	with	with	ADP
fnp-2615	142	17	luxol	luxol	NOUN
fnp-2615	142	18	fast	fast	PROPN
fnp-2615	142	19	blue	blue	PROPN
fnp-2615	142	20	&	&	CCONJ
fnp-2615	142	21	hematoxylin	hematoxylin	PROPN
fnp-2615	142	22	,	,	PUNCT
fnp-2615	142	23	lower	low	ADJ
fnp-2615	142	24	myelin	myelin	NOUN
fnp-2615	142	25	density	density	NOUN
fnp-2615	142	26	as	as	SCONJ
fnp-2615	142	27	assessed	assess	VERB
fnp-2615	142	28	with	with	ADP
fnp-2615	142	29	immunohistochemistry	immunohistochemistry	NOUN
fnp-2615	142	30	against	against	ADP
fnp-2615	142	31	myelin	myelin	ADJ
fnp-2615	142	32	basic	basic	ADJ
fnp-2615	142	33	protein	protein	NOUN
fnp-2615	142	34	,	,	PUNCT
fnp-2615	142	35	and	and	CCONJ
fnp-2615	142	36	decreased	decrease	VERB
fnp-2615	142	37	axonal	axonal	ADJ
fnp-2615	142	38	density	density	NOUN
fnp-2615	142	39	determined	determine	VERB
fnp-2615	142	40	by	by	ADP
fnp-2615	142	41	immunohistochemistry	immunohistochemistry	NOUN
fnp-2615	142	42	against	against	ADP
fnp-2615	142	43	neurofilament	neurofilament	NOUN
fnp-2615	142	44	(	(	PUNCT
fnp-2615	142	45	nf200	nf200	PROPN
fnp-2615	142	46	)	)	PUNCT
fnp-2615	142	47	.	.	PUNCT
fnp-2615	143	1	another	another	DET
fnp-2615	143	2	dti	dti	PROPN
fnp-2615	143	3	parameter	parameter	PROPN
fnp-2615	143	4	,	,	PUNCT
fnp-2615	143	5	mean	mean	VERB
fnp-2615	143	6	diffusivity	diffusivity	NOUN
fnp-2615	143	7	,	,	PUNCT
fnp-2615	143	8	was	be	AUX
fnp-2615	143	9	increased	increase	VERB
fnp-2615	143	10	in	in	ADP
fnp-2615	143	11	cca	cca	PROPN
fnp-2615	143	12	patients	patient	NOUN
fnp-2615	143	13	and	and	CCONJ
fnp-2615	143	14	was	be	AUX
fnp-2615	143	15	independently	independently	ADV
fnp-2615	143	16	associated	associate	VERB
fnp-2615	143	17	with	with	ADP
fnp-2615	143	18	myelin	myelin	NOUN
fnp-2615	143	19	density	density	NOUN
fnp-2615	143	20	(	(	PUNCT
fnp-2615	143	21	van	van	PROPN
fnp-2615	143	22	veluw	veluw	NOUN
fnp-2615	143	23	et	et	PROPN
fnp-2615	143	24	al	al	PROPN
fnp-2615	143	25	.	.	PROPN
fnp-2615	143	26	,	,	PUNCT
fnp-2615	143	27	2019b	2019b	NUM
fnp-2615	143	28	)	)	PUNCT
fnp-2615	143	29	.	.	PUNCT
fnp-2615	144	1	moreover	moreover	ADV
fnp-2615	144	2	,	,	PUNCT
fnp-2615	144	3	increased	increase	VERB
fnp-2615	144	4	mean	mean	ADJ
fnp-2615	144	5	diffusivity	diffusivity	NOUN
fnp-2615	144	6	in	in	ADP
fnp-2615	144	7	the	the	DET
fnp-2615	144	8	frontal	frontal	ADJ
fnp-2615	144	9	white	white	ADJ
fnp-2615	144	10	matter	matter	NOUN
fnp-2615	144	11	was	be	AUX
fnp-2615	144	12	associated	associate	VERB
fnp-2615	144	13	with	with	ADP
fnp-2615	144	14	caa	caa	NOUN
fnp-2615	144	15	severity	severity	NOUN
fnp-2615	144	16	in	in	ADP
fnp-2615	144	17	the	the	DET
fnp-2615	144	18	frontal	frontal	ADJ
fnp-2615	144	19	cortex	cortex	NOUN
fnp-2615	144	20	.	.	PUNCT
fnp-2615	145	1	in	in	ADP
fnp-2615	145	2	contrast	contrast	NOUN
fnp-2615	145	3	,	,	PUNCT
fnp-2615	145	4	the	the	DET
fnp-2615	145	5	dti	dti	PROPN
fnp-2615	145	6	changes	change	NOUN
fnp-2615	145	7	were	be	AUX
fnp-2615	145	8	not	not	PART
fnp-2615	145	9	related	relate	VERB
fnp-2615	145	10	to	to	ADP
fnp-2615	145	11	markers	marker	NOUN
fnp-2615	145	12	of	of	ADP
fnp-2615	145	13	gliosis	gliosis	NOUN
fnp-2615	145	14	or	or	CCONJ
fnp-2615	145	15	with	with	ADP
fnp-2615	145	16	oligodendrocyte	oligodendrocyte	ADJ
fnp-2615	145	17	counts	count	NOUN
fnp-2615	145	18	.	.	PUNCT
fnp-2615	146	1	investigations	investigation	NOUN
fnp-2615	146	2	on	on	ADP
fnp-2615	146	3	the	the	DET
fnp-2615	146	4	neuropathological	neuropathological	ADJ
fnp-2615	146	5	correlates	correlate	NOUN
fnp-2615	146	6	of	of	ADP
fnp-2615	146	7	imaging	imaging	NOUN
fnp-2615	146	8	alterations	alteration	NOUN
fnp-2615	146	9	are	be	AUX
fnp-2615	146	10	important	important	ADJ
fnp-2615	146	11	because	because	SCONJ
fnp-2615	146	12	mri	mri	NOUN
fnp-2615	146	13	is	be	AUX
fnp-2615	146	14	widely	widely	ADV
fnp-2615	146	15	available	available	ADJ
fnp-2615	146	16	and	and	CCONJ
fnp-2615	146	17	can	can	AUX
fnp-2615	146	18	be	be	AUX
fnp-2615	146	19	used	use	VERB
fnp-2615	146	20	to	to	PART
fnp-2615	146	21	follow	follow	VERB
fnp-2615	146	22	the	the	DET
fnp-2615	146	23	progression	progression	NOUN
fnp-2615	146	24	of	of	ADP
fnp-2615	146	25	disease	disease	NOUN
fnp-2615	146	26	.	.	PUNCT
fnp-2615	147	1	6	6	X
fnp-2615	147	2	.	.	X
fnp-2615	147	3	novel	novel	ADJ
fnp-2615	147	4	mechanisms	mechanism	NOUN
fnp-2615	147	5	underlying	underlie	VERB
fnp-2615	147	6	cadasil	cadasil	NOUN
fnp-2615	147	7	vasculopathy	vasculopathy	NOUN
fnp-2615	147	8	cerebral	cerebral	ADJ
fnp-2615	147	9	autosomal	autosomal	ADJ
fnp-2615	147	10	dominant	dominant	ADJ
fnp-2615	147	11	arteriopathy	arteriopathy	NOUN
fnp-2615	147	12	with	with	ADP
fnp-2615	147	13	subcortical	subcortical	ADJ
fnp-2615	147	14	infarcts	infarct	NOUN
fnp-2615	147	15	and	and	CCONJ
fnp-2615	147	16	leukoencephalopathy	leukoencephalopathy	ADV
fnp-2615	147	17	(	(	PUNCT
fnp-2615	147	18	cadasil	cadasil	PROPN
fnp-2615	147	19	)	)	PUNCT
fnp-2615	147	20	is	be	AUX
fnp-2615	147	21	the	the	DET
fnp-2615	147	22	most	most	ADV
fnp-2615	147	23	common	common	ADJ
fnp-2615	147	24	hereditary	hereditary	ADJ
fnp-2615	147	25	monogenic	monogenic	ADJ
fnp-2615	147	26	form	form	NOUN
fnp-2615	147	27	of	of	ADP
fnp-2615	147	28	cerebral	cerebral	ADJ
fnp-2615	147	29	small	small	ADJ
fnp-2615	147	30	vessel	vessel	NOUN
fnp-2615	147	31	disease	disease	NOUN
fnp-2615	147	32	.	.	PUNCT
fnp-2615	148	1	cadasil	cadasil	NOUN
fnp-2615	148	2	leads	lead	VERB
fnp-2615	148	3	to	to	ADP
fnp-2615	148	4	early	early	ADJ
fnp-2615	148	5	onset	onset	VERB
fnp-2615	148	6	hemorrhagic	hemorrhagic	NOUN
fnp-2615	148	7	or	or	CCONJ
fnp-2615	148	8	ischemic	ischemic	ADJ
fnp-2615	148	9	stroke	stroke	NOUN
fnp-2615	148	10	and	and	CCONJ
fnp-2615	148	11	vascular	vascular	ADJ
fnp-2615	148	12	dementia	dementia	NOUN
fnp-2615	148	13	.	.	PUNCT
fnp-2615	149	1	recent	recent	ADJ
fnp-2615	149	2	findings	finding	NOUN
fnp-2615	149	3	in	in	ADP
fnp-2615	149	4	cadasil	cadasil	NOUN
fnp-2615	149	5	unraveled	unravel	VERB
fnp-2615	149	6	novel	novel	ADJ
fnp-2615	149	7	molecular	molecular	ADJ
fnp-2615	149	8	targets	target	NOUN
fnp-2615	149	9	by	by	ADP
fnp-2615	149	10	describing	describe	VERB
fnp-2615	149	11	attenuated	attenuate	VERB
fnp-2615	149	12	vascular	vascular	ADJ
fnp-2615	149	13	dysfunction	dysfunction	NOUN
fnp-2615	149	14	due	due	ADP
fnp-2615	149	15	to	to	ADP
fnp-2615	149	16	inhibitors	inhibitor	NOUN
fnp-2615	149	17	of	of	ADP
fnp-2615	149	18	endoplasmic	endoplasmic	ADJ
fnp-2615	149	19	reticulum	reticulum	NOUN
fnp-2615	149	20	stress	stress	NOUN
fnp-2615	149	21	and	and	CCONJ
fnp-2615	149	22	modulators	modulator	NOUN
fnp-2615	149	23	of	of	ADP
fnp-2615	149	24	the	the	DET
fnp-2615	149	25	cytoskeleton	cytoskeleton	NOUN
fnp-2615	149	26	,	,	PUNCT
fnp-2615	149	27	or	or	CCONJ
fnp-2615	149	28	due	due	ADP
fnp-2615	149	29	to	to	PART
fnp-2615	149	30	vascular	vascular	VERB
fnp-2615	149	31	endothelial	endothelial	ADJ
fnp-2615	149	32	growth	growth	NOUN
fnp-2615	149	33	factor	factor	NOUN
fnp-2615	149	34	supplementation	supplementation	NOUN
fnp-2615	149	35	.	.	PUNCT
fnp-2615	150	1	cadasil	cadasil	NOUN
fnp-2615	150	2	pathology	pathology	PROPN
fnp-2615	150	3	develops	develop	VERB
fnp-2615	150	4	due	due	ADJ
fnp-2615	150	5	to	to	ADP
fnp-2615	150	6	mutations	mutation	NOUN
fnp-2615	150	7	in	in	ADP
fnp-2615	150	8	the	the	DET
fnp-2615	150	9	notch3	notch3	PROPN
fnp-2615	150	10	gene	gene	NOUN
fnp-2615	150	11	which	which	PRON
fnp-2615	150	12	result	result	VERB
fnp-2615	150	13	in	in	ADP
fnp-2615	150	14	dysfunction	dysfunction	NOUN
fnp-2615	150	15	of	of	ADP
fnp-2615	150	16	vascular	vascular	ADJ
fnp-2615	150	17	smcs	smcs	NOUN
fnp-2615	150	18	.	.	PUNCT
fnp-2615	151	1	notch3	notch3	PROPN
fnp-2615	151	2	is	be	AUX
fnp-2615	151	3	involved	involve	VERB
fnp-2615	151	4	in	in	ADP
fnp-2615	151	5	vasculogenesis	vasculogenesis	NOUN
fnp-2615	151	6	and	and	CCONJ
fnp-2615	151	7	is	be	AUX
fnp-2615	151	8	mainly	mainly	ADV
fnp-2615	151	9	expressed	express	VERB
fnp-2615	151	10	in	in	ADP
fnp-2615	151	11	smcs	smcs	ADJ
fnp-2615	151	12	in	in	ADP
fnp-2615	151	13	adults	adult	NOUN
fnp-2615	151	14	.	.	PUNCT
fnp-2615	152	1	however	however	ADV
fnp-2615	152	2	,	,	PUNCT
fnp-2615	152	3	no	no	DET
fnp-2615	152	4	specific	specific	ADJ
fnp-2615	152	5	therapies	therapy	NOUN
fnp-2615	152	6	have	have	AUX
fnp-2615	152	7	been	be	AUX
fnp-2615	152	8	developed	develop	VERB
fnp-2615	152	9	so	so	ADV
fnp-2615	152	10	far	far	ADV
fnp-2615	152	11	,	,	PUNCT
fnp-2615	152	12	possibly	possibly	ADV
fnp-2615	152	13	because	because	SCONJ
fnp-2615	152	14	there	there	PRON
fnp-2615	152	15	are	be	VERB
fnp-2615	152	16	many	many	ADJ
fnp-2615	152	17	aspects	aspect	NOUN
fnp-2615	152	18	of	of	ADP
fnp-2615	152	19	notch3	notch3	ADJ
fnp-2615	152	20	function	function	NOUN
fnp-2615	152	21	that	that	PRON
fnp-2615	152	22	remain	remain	VERB
fnp-2615	152	23	currently	currently	ADV
fnp-2615	152	24	unknown	unknown	ADJ
fnp-2615	152	25	.	.	PUNCT
fnp-2615	153	1	a	a	DET
fnp-2615	153	2	recent	recent	ADJ
fnp-2615	153	3	study	study	NOUN
fnp-2615	153	4	(	(	PUNCT
fnp-2615	153	5	neves	neve	NOUN
fnp-2615	153	6	et	et	PROPN
fnp-2615	153	7	al	al	PROPN
fnp-2615	153	8	.	.	PROPN
fnp-2615	153	9	2019	2019	NUM
fnp-2615	153	10	)	)	PUNCT
fnp-2615	153	11	identified	identify	VERB
fnp-2615	153	12	molecular	molecular	ADJ
fnp-2615	153	13	targets	target	NOUN
fnp-2615	153	14	involved	involve	VERB
fnp-2615	153	15	in	in	ADP
fnp-2615	153	16	vascular	vascular	ADJ
fnp-2615	153	17	dysfunction	dysfunction	NOUN
fnp-2615	153	18	in	in	ADP
fnp-2615	153	19	cadasil	cadasil	NOUN
fnp-2615	153	20	.	.	PUNCT
fnp-2615	154	1	notably	notably	ADV
fnp-2615	154	2	,	,	PUNCT
fnp-2615	154	3	the	the	DET
fnp-2615	154	4	study	study	NOUN
fnp-2615	154	5	replicates	replicate	VERB
fnp-2615	154	6	in	in	ADP
fnp-2615	154	7	a	a	DET
fnp-2615	154	8	cadasil	cadasil	NOUN
fnp-2615	154	9	mouse	mouse	NOUN
fnp-2615	154	10	model	model	NOUN
fnp-2615	154	11	,	,	PUNCT
fnp-2615	154	12	the	the	DET
fnp-2615	154	13	tgnotch3r169c	tgnotch3r169c	PROPN
fnp-2615	154	14	mouse	mouse	PROPN
fnp-2615	154	15	,	,	PUNCT
fnp-2615	154	16	the	the	DET
fnp-2615	154	17	same	same	ADJ
fnp-2615	154	18	findings	finding	NOUN
fnp-2615	154	19	as	as	ADP
fnp-2615	154	20	in	in	ADP
fnp-2615	154	21	human	human	ADJ
fnp-2615	154	22	cadasil	cadasil	NOUN
fnp-2615	154	23	.	.	PUNCT
fnp-2615	155	1	samples	sample	NOUN
fnp-2615	155	2	were	be	AUX
fnp-2615	155	3	obtained	obtain	VERB
fnp-2615	155	4	from	from	ADP
fnp-2615	155	5	peripheral	peripheral	ADJ
fnp-2615	155	6	biopsies	biopsy	NOUN
fnp-2615	155	7	of	of	ADP
fnp-2615	155	8	cadasil	cadasil	NOUN
fnp-2615	155	9	patients	patient	NOUN
fnp-2615	155	10	.	.	PUNCT
fnp-2615	156	1	molecular	molecular	ADJ
fnp-2615	156	2	alterations	alteration	NOUN
fnp-2615	156	3	were	be	AUX
fnp-2615	156	4	identified	identify	VERB
fnp-2615	156	5	in	in	ADP
fnp-2615	156	6	peripheral	peripheral	ADJ
fnp-2615	156	7	arteries	artery	NOUN
fnp-2615	156	8	despite	despite	SCONJ
fnp-2615	156	9	the	the	DET
fnp-2615	156	10	fact	fact	NOUN
fnp-2615	156	11	that	that	SCONJ
fnp-2615	156	12	cadasil	cadasil	NOUN
fnp-2615	156	13	pathology	pathology	NOUN
fnp-2615	156	14	manifests	manifest	VERB
fnp-2615	156	15	principally	principally	ADV
fnp-2615	156	16	in	in	ADP
fnp-2615	156	17	cerebral	cerebral	ADJ
fnp-2615	156	18	vessels	vessel	NOUN
fnp-2615	156	19	.	.	PUNCT
fnp-2615	157	1	peripheral	peripheral	ADJ
fnp-2615	157	2	vessels	vessel	NOUN
fnp-2615	157	3	of	of	ADP
fnp-2615	157	4	cadasil	cadasil	NOUN
fnp-2615	157	5	patients	patient	NOUN
fnp-2615	157	6	showed	show	VERB
fnp-2615	157	7	impaired	impaired	ADJ
fnp-2615	157	8	vascular	vascular	ADJ
fnp-2615	157	9	reactivity	reactivity	NOUN
fnp-2615	157	10	and	and	CCONJ
fnp-2615	157	11	altered	alter	VERB
fnp-2615	157	12	vascular	vascular	ADJ
fnp-2615	157	13	structure	structure	NOUN
fnp-2615	157	14	with	with	ADP
fnp-2615	157	15	features	feature	NOUN
fnp-2615	157	16	suggesting	suggest	VERB
fnp-2615	157	17	reduced	reduce	VERB
fnp-2615	157	18	stiffness	stiffness	NOUN
fnp-2615	157	19	.	.	PUNCT
fnp-2615	158	1	alterations	alteration	NOUN
fnp-2615	158	2	in	in	ADP
fnp-2615	158	3	smc	smc	PROPN
fnp-2615	158	4	proliferation	proliferation	NOUN
fnp-2615	158	5	,	,	PUNCT
fnp-2615	158	6	apoptosis	apoptosis	NOUN
fnp-2615	158	7	,	,	PUNCT
fnp-2615	158	8	and	and	CCONJ
fnp-2615	158	9	cytoskeletal	cytoskeletal	ADJ
fnp-2615	158	10	disorganization	disorganization	NOUN
fnp-2615	158	11	was	be	AUX
fnp-2615	158	12	also	also	ADV
fnp-2615	158	13	noted	note	VERB
fnp-2615	158	14	.	.	PUNCT
fnp-2615	159	1	vascular	vascular	ADJ
fnp-2615	159	2	smcs	smcs	NOUN
fnp-2615	159	3	of	of	ADP
fnp-2615	159	4	cadasil	cadasil	NOUN
fnp-2615	159	5	patients	patient	NOUN
fnp-2615	159	6	showed	show	VERB
fnp-2615	159	7	increased	increase	VERB
fnp-2615	159	8	notch3	notch3	ADJ
fnp-2615	159	9	signaling	signaling	NOUN
fnp-2615	159	10	,	,	PUNCT
fnp-2615	159	11	notch3	notch3	PROPN
fnp-2615	159	12	ectodomain	ectodomain	NOUN
fnp-2615	159	13	(	(	PUNCT
fnp-2615	159	14	notch3ecd	notch3ecd	NUM
fnp-2615	159	15	)	)	PUNCT
fnp-2615	159	16	accumulation	accumulation	NOUN
fnp-2615	159	17	,	,	PUNCT
fnp-2615	159	18	and	and	CCONJ
fnp-2615	159	19	expression	expression	NOUN
fnp-2615	159	20	of	of	ADP
fnp-2615	159	21	notch3	notch3	ADJ
fnp-2615	159	22	target	target	NOUN
fnp-2615	159	23	genes	gene	NOUN
fnp-2615	159	24	relative	relative	ADJ
fnp-2615	159	25	to	to	ADP
fnp-2615	159	26	control	control	NOUN
fnp-2615	159	27	patients	patient	NOUN
fnp-2615	159	28	.	.	PUNCT
fnp-2615	160	1	the	the	DET
fnp-2615	160	2	study	study	NOUN
fnp-2615	160	3	also	also	ADV
fnp-2615	160	4	showed	show	VERB
fnp-2615	160	5	nox5	nox5	NOUN
fnp-2615	160	6	upregulation	upregulation	NOUN
fnp-2615	160	7	linked	link	VERB
fnp-2615	160	8	to	to	ADP
fnp-2615	160	9	an	an	DET
fnp-2615	160	10	exaggerated	exaggerated	ADJ
fnp-2615	160	11	endoplasmic	endoplasmic	ADJ
fnp-2615	160	12	reticulum	reticulum	NOUN
fnp-2615	160	13	stress	stress	NOUN
fnp-2615	160	14	response	response	NOUN
fnp-2615	160	15	and	and	CCONJ
fnp-2615	160	16	aberrant	aberrant	ADJ
fnp-2615	160	17	cytoskeleton	cytoskeleton	NOUN
fnp-2615	160	18	-	-	PUNCT
fnp-2615	160	19	associated	associate	VERB
fnp-2615	160	20	protein	protein	NOUN
fnp-2615	160	21	phosphorylation	phosphorylation	NOUN
fnp-2615	160	22	in	in	ADP
fnp-2615	160	23	cadasil	cadasil	NOUN
fnp-2615	160	24	.	.	PUNCT
fnp-2615	161	1	moreover	moreover	ADV
fnp-2615	161	2	,	,	PUNCT
fnp-2615	161	3	the	the	DET
fnp-2615	161	4	study	study	NOUN
fnp-2615	161	5	reports	report	VERB
fnp-2615	161	6	that	that	SCONJ
fnp-2615	161	7	inhibitors	inhibitor	NOUN
fnp-2615	161	8	of	of	ADP
fnp-2615	161	9	notch3	notch3	PROPN
fnp-2615	161	10	,	,	PUNCT
fnp-2615	161	11	nox5	nox5	NOUN
fnp-2615	161	12	,	,	PUNCT
fnp-2615	161	13	er	er	INTJ
fnp-2615	161	14	stress	stress	NOUN
fnp-2615	161	15	,	,	PUNCT
fnp-2615	161	16	and	and	CCONJ
fnp-2615	161	17	rhoa	rhoa	PROPN
fnp-2615	161	18	/	/	SYM
fnp-2615	161	19	rho	rho	ADJ
fnp-2615	161	20	kinase	kinase	NOUN
fnp-2615	161	21	attenuate	attenuate	VERB
fnp-2615	161	22	vascular	vascular	ADJ
fnp-2615	161	23	dysfunction	dysfunction	NOUN
fnp-2615	161	24	.	.	PUNCT
fnp-2615	162	1	this	this	DET
fnp-2615	162	2	finding	finding	NOUN
fnp-2615	162	3	identifies	identify	VERB
fnp-2615	162	4	putative	putative	ADJ
fnp-2615	162	5	pharmacologic	pharmacologic	ADJ
fnp-2615	162	6	therapeutic	therapeutic	ADJ
fnp-2615	162	7	targets	target	NOUN
fnp-2615	162	8	.	.	PUNCT
fnp-2615	163	1	vascular	vascular	ADJ
fnp-2615	163	2	smcs	smcs	NOUN
fnp-2615	163	3	in	in	ADP
fnp-2615	163	4	cadasil	cadasil	NOUN
fnp-2615	163	5	are	be	AUX
fnp-2615	163	6	surrounded	surround	VERB
fnp-2615	163	7	by	by	ADP
fnp-2615	163	8	deposits	deposit	NOUN
fnp-2615	163	9	of	of	ADP
fnp-2615	163	10	granular	granular	ADJ
fnp-2615	163	11	osmiophilic	osmiophilic	NOUN
fnp-2615	163	12	material	material	NOUN
fnp-2615	163	13	(	(	PUNCT
fnp-2615	163	14	gom	gom	NOUN
fnp-2615	163	15	)	)	PUNCT
fnp-2615	163	16	.	.	PUNCT
fnp-2615	164	1	however	however	ADV
fnp-2615	164	2	,	,	PUNCT
fnp-2615	164	3	the	the	DET
fnp-2615	164	4	mechanisms	mechanism	NOUN
fnp-2615	164	5	underlying	underlie	VERB
fnp-2615	164	6	gom	gom	NOUN
fnp-2615	164	7	formation	formation	NOUN
fnp-2615	164	8	and	and	CCONJ
fnp-2615	164	9	their	their	PRON
fnp-2615	164	10	contribution	contribution	NOUN
fnp-2615	164	11	to	to	ADP
fnp-2615	164	12	disease	disease	NOUN
fnp-2615	164	13	progression	progression	NOUN
fnp-2615	164	14	are	be	AUX
fnp-2615	164	15	unknown	unknown	ADJ
fnp-2615	164	16	.	.	PUNCT
fnp-2615	165	1	a	a	DET
fnp-2615	165	2	recent	recent	ADJ
fnp-2615	165	3	study	study	NOUN
fnp-2615	165	4	investigated	investigate	VERB
fnp-2615	165	5	the	the	DET
fnp-2615	165	6	course	course	NOUN
fnp-2615	165	7	of	of	ADP
fnp-2615	165	8	gom	gom	NOUN
fnp-2615	165	9	deposit	deposit	NOUN
fnp-2615	165	10	evolution	evolution	NOUN
fnp-2615	165	11	in	in	ADP
fnp-2615	165	12	humanized	humanize	VERB
fnp-2615	165	13	tgnotch3arg182cys	tgnotch3arg182cys	ADJ
fnp-2615	165	14	mice	mouse	NOUN
fnp-2615	165	15	(	(	PUNCT
fnp-2615	165	16	gravesteijn	gravesteijn	NOUN
fnp-2615	165	17	et	et	PROPN
fnp-2615	165	18	al	al	PROPN
fnp-2615	165	19	.	.	PROPN
fnp-2615	165	20	,	,	PUNCT
fnp-2615	165	21	2019	2019	NUM
fnp-2615	165	22	)	)	PUNCT
fnp-2615	165	23	and	and	CCONJ
fnp-2615	165	24	in	in	ADP
fnp-2615	165	25	human	human	ADJ
fnp-2615	165	26	cadasil	cadasil	NOUN
fnp-2615	165	27	tissue	tissue	NOUN
fnp-2615	165	28	.	.	PUNCT
fnp-2615	166	1	gom	gom	NOUN
fnp-2615	166	2	deposits	deposit	NOUN
fnp-2615	166	3	are	be	AUX
fnp-2615	166	4	electron	electron	NOUN
fnp-2615	166	5	dense	dense	ADJ
fnp-2615	166	6	and	and	CCONJ
fnp-2615	166	7	are	be	AUX
fnp-2615	166	8	composed	compose	VERB
fnp-2615	166	9	of	of	ADP
fnp-2615	166	10	notch3ecd	notch3ecd	NOUN
fnp-2615	166	11	and	and	CCONJ
fnp-2615	166	12	extracellular	extracellular	ADJ
fnp-2615	166	13	matrix	matrix	NOUN
fnp-2615	166	14	proteins	protein	NOUN
fnp-2615	166	15	,	,	PUNCT
fnp-2615	166	16	notably	notably	ADV
fnp-2615	166	17	tissue	tissue	NOUN
fnp-2615	166	18	inhibitor	inhibitor	NOUN
fnp-2615	166	19	of	of	ADP
fnp-2615	166	20	metalloproteinase	metalloproteinase	PROPN
fnp-2615	166	21	3	3	NUM
fnp-2615	166	22	(	(	PUNCT
fnp-2615	166	23	timp3	timp3	NOUN
fnp-2615	166	24	)	)	PUNCT
fnp-2615	166	25	and	and	CCONJ
fnp-2615	166	26	clusterin	clusterin	NOUN
fnp-2615	166	27	,	,	PUNCT
fnp-2615	166	28	that	that	PRON
fnp-2615	166	29	accumulate	accumulate	VERB
fnp-2615	166	30	in	in	ADP
fnp-2615	166	31	the	the	DET
fnp-2615	166	32	basement	basement	NOUN
fnp-2615	166	33	membrane	membrane	NOUN
fnp-2615	166	34	of	of	ADP
fnp-2615	166	35	vascular	vascular	ADJ
fnp-2615	166	36	smcs	smcs	ADJ
fnp-2615	166	37	and	and	CCONJ
fnp-2615	166	38	pericytes	pericyte	NOUN
fnp-2615	166	39	.	.	PUNCT
fnp-2615	167	1	the	the	DET
fnp-2615	167	2	study	study	NOUN
fnp-2615	167	3	proposes	propose	VERB
fnp-2615	167	4	a	a	DET
fnp-2615	167	5	five	five	NUM
fnp-2615	167	6	-	-	PUNCT
fnp-2615	167	7	stage	stage	NOUN
fnp-2615	167	8	gom	gom	NOUN
fnp-2615	167	9	classification	classification	NOUN
fnp-2615	167	10	system	system	NOUN
fnp-2615	167	11	based	base	VERB
fnp-2615	167	12	on	on	ADP
fnp-2615	167	13	size	size	NOUN
fnp-2615	167	14	,	,	PUNCT
fnp-2615	167	15	morphology	morphology	NOUN
fnp-2615	167	16	,	,	PUNCT
fnp-2615	167	17	and	and	CCONJ
fnp-2615	167	18	electron	electron	NOUN
fnp-2615	167	19	density	density	NOUN
fnp-2615	167	20	of	of	ADP
fnp-2615	167	21	the	the	DET
fnp-2615	167	22	gom	gom	NOUN
fnp-2615	167	23	deposits	deposit	NOUN
fnp-2615	167	24	in	in	ADP
fnp-2615	167	25	order	order	NOUN
fnp-2615	167	26	to	to	PART
fnp-2615	167	27	generate	generate	VERB
fnp-2615	167	28	a	a	DET
fnp-2615	167	29	more	more	ADV
fnp-2615	167	30	systematic	systematic	ADJ
fnp-2615	167	31	,	,	PUNCT
fnp-2615	167	32	uniform	uniform	ADJ
fnp-2615	167	33	,	,	PUNCT
fnp-2615	167	34	and	and	CCONJ
fnp-2615	167	35	unbiased	unbiased	ADJ
fnp-2615	167	36	way	way	NOUN
fnp-2615	167	37	of	of	ADP
fnp-2615	167	38	analyzing	analyze	VERB
fnp-2615	167	39	gom	gom	NOUN
fnp-2615	167	40	accumulations	accumulation	NOUN
fnp-2615	167	41	.	.	PUNCT
fnp-2615	168	1	it	it	PRON
fnp-2615	168	2	appears	appear	VERB
fnp-2615	168	3	that	that	SCONJ
fnp-2615	168	4	new	new	ADJ
fnp-2615	168	5	gom	gom	NOUN
fnp-2615	168	6	deposits	deposit	NOUN
fnp-2615	168	7	are	be	AUX
fnp-2615	168	8	continuously	continuously	ADV
fnp-2615	168	9	generated	generate	VERB
fnp-2615	168	10	.	.	PUNCT
fnp-2615	169	1	however	however	ADV
fnp-2615	169	2	,	,	PUNCT
fnp-2615	169	3	gom	gom	NOUN
fnp-2615	169	4	in	in	ADP
fnp-2615	169	5	tgnotch3arg182cys	tgnotch3arg182cys	ADJ
fnp-2615	169	6	mice	mouse	NOUN
fnp-2615	169	7	did	do	AUX
fnp-2615	169	8	not	not	PART
fnp-2615	169	9	reach	reach	VERB
fnp-2615	169	10	the	the	DET
fnp-2615	169	11	end	end	NOUN
fnp-2615	169	12	-	-	PUNCT
fnp-2615	169	13	stage	stage	NOUN
fnp-2615	169	14	of	of	ADP
fnp-2615	169	15	gom	gom	NOUN
fnp-2615	169	16	accumulation	accumulation	NOUN
fnp-2615	169	17	as	as	ADP
fnp-2615	169	18	in	in	ADP
fnp-2615	169	19	human	human	ADJ
fnp-2615	169	20	disease	disease	NOUN
fnp-2615	169	21	.	.	PUNCT
fnp-2615	170	1	a	a	DET
fnp-2615	170	2	limitation	limitation	NOUN
fnp-2615	170	3	of	of	ADP
fnp-2615	170	4	the	the	DET
fnp-2615	170	5	study	study	NOUN
fnp-2615	170	6	is	be	AUX
fnp-2615	170	7	that	that	SCONJ
fnp-2615	170	8	unlike	unlike	ADP
fnp-2615	170	9	other	other	ADJ
fnp-2615	170	10	cadasil	cadasil	NOUN
fnp-2615	170	11	mouse	mouse	NOUN
fnp-2615	170	12	models	model	NOUN
fnp-2615	170	13	,	,	PUNCT
fnp-2615	170	14	the	the	DET
fnp-2615	170	15	tgnotch3arg182cys	tgnotch3arg182cys	NOUN
fnp-2615	170	16	mouse	mouse	NOUN
fnp-2615	170	17	lacks	lack	VERB
fnp-2615	170	18	histologic	histologic	ADJ
fnp-2615	170	19	vascular	vascular	ADJ
fnp-2615	170	20	pathology	pathology	NOUN
fnp-2615	170	21	and	and	CCONJ
fnp-2615	170	22	functional	functional	ADJ
fnp-2615	170	23	deficits	deficit	NOUN
fnp-2615	170	24	.	.	PUNCT
fnp-2615	171	1	the	the	DET
fnp-2615	171	2	authors	author	NOUN
fnp-2615	171	3	suggest	suggest	VERB
fnp-2615	171	4	that	that	SCONJ
fnp-2615	171	5	this	this	DET
fnp-2615	171	6	phenomenon	phenomenon	NOUN
fnp-2615	171	7	could	could	AUX
fnp-2615	171	8	be	be	AUX
fnp-2615	171	9	attributed	attribute	VERB
fnp-2615	171	10	to	to	ADP
fnp-2615	171	11	absence	absence	NOUN
fnp-2615	171	12	of	of	ADP
fnp-2615	171	13	end	end	NOUN
fnp-2615	171	14	-	-	PUNCT
fnp-2615	171	15	stage	stage	NOUN
fnp-2615	171	16	gom	gom	NOUN
fnp-2615	171	17	accumulation	accumulation	NOUN
fnp-2615	171	18	in	in	ADP
fnp-2615	171	19	these	these	DET
fnp-2615	171	20	mice	mouse	NOUN
fnp-2615	171	21	.	.	PUNCT
fnp-2615	172	1	beyond	beyond	ADP
fnp-2615	172	2	mouse	mouse	NOUN
fnp-2615	172	3	models	model	NOUN
fnp-2615	172	4	,	,	PUNCT
fnp-2615	172	5	the	the	DET
fnp-2615	172	6	cellular	cellular	ADJ
fnp-2615	172	7	cadasil	cadasil	NOUN
fnp-2615	172	8	pathology	pathology	NOUN
fnp-2615	172	9	has	have	AUX
fnp-2615	172	10	been	be	AUX
fnp-2615	172	11	investigated	investigate	VERB
fnp-2615	172	12	in	in	ADP
fnp-2615	172	13	patient	patient	NOUN
fnp-2615	172	14	-	-	PUNCT
fnp-2615	172	15	specific	specific	ADJ
fnp-2615	172	16	vascular	vascular	ADJ
fnp-2615	172	17	mural	mural	ADJ
fnp-2615	172	18	cells	cell	NOUN
fnp-2615	172	19	generated	generate	VERB
fnp-2615	172	20	from	from	ADP
fnp-2615	172	21	induced	induce	VERB
fnp-2615	172	22	pluripotent	pluripotent	ADJ
fnp-2615	172	23	stem	stem	NOUN
fnp-2615	172	24	cells	cell	NOUN
fnp-2615	172	25	(	(	PUNCT
fnp-2615	172	26	ipscs	ipsc	NOUN
fnp-2615	172	27	)	)	PUNCT
fnp-2615	172	28	obtained	obtain	VERB
fnp-2615	172	29	from	from	ADP
fnp-2615	172	30	skin	skin	NOUN
fnp-2615	172	31	biopsies	biopsy	NOUN
fnp-2615	172	32	of	of	ADP
fnp-2615	172	33	cadasil	cadasil	NOUN
fnp-2615	172	34	patients	patient	NOUN
fnp-2615	172	35	(	(	PUNCT
fnp-2615	172	36	kelleher	kelleher	PROPN
fnp-2615	172	37	et	et	PROPN
fnp-2615	172	38	al	al	PROPN
fnp-2615	172	39	.	.	PROPN
fnp-2615	172	40	,	,	PUNCT
fnp-2615	172	41	2019	2019	NUM
fnp-2615	172	42	)	)	PUNCT
fnp-2615	172	43	.	.	PUNCT
fnp-2615	173	1	this	this	DET
fnp-2615	173	2	study	study	NOUN
fnp-2615	173	3	showed	show	VERB
fnp-2615	173	4	alterations	alteration	NOUN
fnp-2615	173	5	in	in	ADP
fnp-2615	173	6	endothelial	endothelial	ADJ
fnp-2615	173	7	capillary	capillary	ADJ
fnp-2615	173	8	structures	structure	NOUN
fnp-2615	173	9	caused	cause	VERB
fnp-2615	173	10	by	by	ADP
fnp-2615	173	11	the	the	DET
fnp-2615	173	12	aberrant	aberrant	ADJ
fnp-2615	173	13	notch3	notch3	ADJ
fnp-2615	173	14	expression	expression	NOUN
fnp-2615	173	15	in	in	ADP
fnp-2615	173	16	mural	mural	ADJ
fnp-2615	173	17	cells	cell	NOUN
fnp-2615	173	18	,	,	PUNCT
fnp-2615	173	19	and	and	CCONJ
fnp-2615	173	20	corrective	corrective	ADJ
fnp-2615	173	21	effects	effect	NOUN
fnp-2615	173	22	of	of	ADP
fnp-2615	173	23	vascular	vascular	ADJ
fnp-2615	173	24	endothelial	endothelial	ADJ
fnp-2615	173	25	growth	growth	NOUN
fnp-2615	173	26	factor	factor	NOUN
fnp-2615	173	27	supplementation	supplementation	NOUN
fnp-2615	173	28	.	.	PUNCT
fnp-2615	174	1	these	these	DET
fnp-2615	174	2	novel	novel	NOUN
fnp-2615	174	3	advances	advance	NOUN
fnp-2615	174	4	are	be	AUX
fnp-2615	174	5	steps	step	NOUN
fnp-2615	174	6	toward	toward	ADP
fnp-2615	174	7	the	the	DET
fnp-2615	174	8	identification	identification	NOUN
fnp-2615	174	9	of	of	ADP
fnp-2615	174	10	novel	novel	ADJ
fnp-2615	174	11	therapeutic	therapeutic	ADJ
fnp-2615	174	12	targets	target	NOUN
fnp-2615	174	13	in	in	ADP
fnp-2615	174	14	this	this	DET
fnp-2615	174	15	monogenic	monogenic	ADJ
fnp-2615	174	16	form	form	NOUN
fnp-2615	174	17	of	of	ADP
fnp-2615	174	18	small	small	ADJ
fnp-2615	174	19	vessel	vessel	NOUN
fnp-2615	174	20	disease	disease	NOUN
fnp-2615	174	21	.	.	PUNCT
fnp-2615	175	1	7	7	X
fnp-2615	175	2	.	.	X
fnp-2615	175	3	genetic	genetic	ADJ
fnp-2615	175	4	variants	variant	NOUN
fnp-2615	175	5	in	in	ADP
fnp-2615	175	6	small	small	ADJ
fnp-2615	175	7	vessel	vessel	NOUN
fnp-2615	175	8	disease	disease	NOUN
fnp-2615	175	9	and	and	CCONJ
fnp-2615	175	10	molecular	molecular	ADJ
fnp-2615	175	11	target	target	NOUN
fnp-2615	175	12	discovery	discovery	NOUN
fnp-2615	175	13	in	in	ADP
fnp-2615	175	14	addition	addition	NOUN
fnp-2615	175	15	to	to	ADP
fnp-2615	175	16	studies	study	NOUN
fnp-2615	175	17	examining	examine	VERB
fnp-2615	175	18	monogenic	monogenic	ADJ
fnp-2615	175	19	forms	form	NOUN
fnp-2615	175	20	of	of	ADP
fnp-2615	175	21	small	small	ADJ
fnp-2615	175	22	vessel	vessel	NOUN
fnp-2615	175	23	disease	disease	NOUN
fnp-2615	175	24	,	,	PUNCT
fnp-2615	175	25	there	there	PRON
fnp-2615	175	26	are	be	VERB
fnp-2615	175	27	efforts	effort	NOUN
fnp-2615	175	28	to	to	PART
fnp-2615	175	29	study	study	VERB
fnp-2615	175	30	genetic	genetic	ADJ
fnp-2615	175	31	variation	variation	NOUN
fnp-2615	175	32	in	in	ADP
fnp-2615	175	33	large	large	ADJ
fnp-2615	175	34	cohorts	cohort	NOUN
fnp-2615	175	35	of	of	ADP
fnp-2615	175	36	patients	patient	NOUN
fnp-2615	175	37	to	to	PART
fnp-2615	175	38	identify	identify	VERB
fnp-2615	175	39	genes	gene	NOUN
fnp-2615	175	40	involved	involve	VERB
fnp-2615	175	41	in	in	ADP
fnp-2615	175	42	sporadic	sporadic	ADJ
fnp-2615	175	43	small	small	ADJ
fnp-2615	175	44	vessel	vessel	NOUN
fnp-2615	175	45	disease	disease	NOUN
fnp-2615	175	46	.	.	PUNCT
fnp-2615	176	1	genome	genome	NOUN
fnp-2615	176	2	-	-	PUNCT
fnp-2615	176	3	wide	wide	ADJ
fnp-2615	176	4	association	association	NOUN
fnp-2615	176	5	studies	study	NOUN
fnp-2615	176	6	correlating	correlate	VERB
fnp-2615	176	7	variants	variant	NOUN
fnp-2615	176	8	with	with	ADP
fnp-2615	176	9	mri	mri	NOUN
fnp-2615	176	10	features	feature	NOUN
fnp-2615	176	11	of	of	ADP
fnp-2615	176	12	sporadic	sporadic	ADJ
fnp-2615	176	13	small	small	ADJ
fnp-2615	176	14	vessel	vessel	NOUN
fnp-2615	176	15	disease	disease	NOUN
fnp-2615	176	16	may	may	AUX
fnp-2615	176	17	lead	lead	VERB
fnp-2615	176	18	to	to	ADP
fnp-2615	176	19	the	the	DET
fnp-2615	176	20	identification	identification	NOUN
fnp-2615	176	21	of	of	ADP
fnp-2615	176	22	new	new	ADJ
fnp-2615	176	23	putative	putative	ADJ
fnp-2615	176	24	pharmacologic	pharmacologic	ADJ
fnp-2615	176	25	targets	target	NOUN
fnp-2615	176	26	.	.	PUNCT
fnp-2615	177	1	small	small	ADJ
fnp-2615	177	2	vessel	vessel	NOUN
fnp-2615	177	3	disease	disease	NOUN
fnp-2615	177	4	is	be	AUX
fnp-2615	177	5	often	often	ADV
fnp-2615	177	6	diagnosed	diagnose	VERB
fnp-2615	177	7	on	on	ADP
fnp-2615	177	8	mri	mri	NOUN
fnp-2615	177	9	,	,	PUNCT
fnp-2615	177	10	with	with	ADP
fnp-2615	177	11	characteristic	characteristic	ADJ
fnp-2615	177	12	findings	finding	NOUN
fnp-2615	177	13	including	include	VERB
fnp-2615	177	14	white	white	ADJ
fnp-2615	177	15	matter	matter	NOUN
fnp-2615	177	16	hyperintensities	hyperintensitie	NOUN
fnp-2615	177	17	and	and	CCONJ
fnp-2615	177	18	signs	sign	NOUN
fnp-2615	177	19	of	of	ADP
fnp-2615	177	20	lacunar	lacunar	ADJ
fnp-2615	177	21	infarcts	infarct	NOUN
fnp-2615	177	22	(	(	PUNCT
fnp-2615	177	23	fig	fig	NOUN
fnp-2615	177	24	.	.	PUNCT
fnp-2615	178	1	2	2	NUM
fnp-2615	178	2	)	)	PUNCT
fnp-2615	178	3	.	.	PUNCT
fnp-2615	179	1	some	some	DET
fnp-2615	179	2	recent	recent	ADJ
fnp-2615	179	3	studies	study	NOUN
fnp-2615	179	4	investigated	investigate	VERB
fnp-2615	179	5	the	the	DET
fnp-2615	179	6	relationship	relationship	NOUN
fnp-2615	179	7	between	between	ADP
fnp-2615	179	8	genetics	genetic	NOUN
fnp-2615	179	9	and	and	CCONJ
fnp-2615	179	10	white	white	ADJ
fnp-2615	179	11	matter	matter	NOUN
fnp-2615	179	12	hyperintensities	hyperintensitie	NOUN
fnp-2615	179	13	in	in	ADP
fnp-2615	179	14	small	small	ADJ
fnp-2615	179	15	vessel	vessel	NOUN
fnp-2615	179	16	disease	disease	NOUN
fnp-2615	179	17	.	.	PUNCT
fnp-2615	180	1	traylor	traylor	PROPN
fnp-2615	180	2	et	et	PROPN
fnp-2615	180	3	al	al	PROPN
fnp-2615	180	4	(	(	PUNCT
fnp-2615	180	5	2019	2019	NUM
fnp-2615	180	6	)	)	PUNCT
fnp-2615	180	7	carried	carry	VERB
fnp-2615	180	8	out	out	ADP
fnp-2615	180	9	a	a	DET
fnp-2615	180	10	genome	genome	NOUN
fnp-2615	180	11	-	-	PUNCT
fnp-2615	180	12	wide	wide	ADJ
fnp-2615	180	13	association	association	NOUN
fnp-2615	180	14	meta	meta	X
fnp-2615	180	15	-	-	PUNCT
fnp-2615	180	16	analysis	analysis	NOUN
fnp-2615	180	17	of	of	ADP
fnp-2615	180	18	white	white	ADJ
fnp-2615	180	19	matter	matter	NOUN
fnp-2615	180	20	hyperintensity	hyperintensity	NOUN
fnp-2615	180	21	volumes	volume	NOUN
fnp-2615	180	22	in	in	ADP
fnp-2615	180	23	11,226	11,226	NUM
fnp-2615	180	24	subjects	subject	NOUN
fnp-2615	180	25	,	,	PUNCT
fnp-2615	180	26	including	include	VERB
fnp-2615	180	27	2,797	2,797	NUM
fnp-2615	180	28	stroke	stroke	NOUN
fnp-2615	180	29	patients	patient	NOUN
fnp-2615	180	30	.	.	PUNCT
fnp-2615	181	1	the	the	DET
fnp-2615	181	2	study	study	NOUN
fnp-2615	181	3	identified	identify	VERB
fnp-2615	181	4	a	a	DET
fnp-2615	181	5	locus	locus	NOUN
fnp-2615	181	6	at	at	ADP
fnp-2615	181	7	genome	genome	NOUN
fnp-2615	181	8	-	-	PUNCT
fnp-2615	181	9	wide	wide	ADJ
fnp-2615	181	10	significance	significance	NOUN
fnp-2615	181	11	in	in	ADP
fnp-2615	181	12	an	an	DET
fnp-2615	181	13	intron	intron	NOUN
fnp-2615	181	14	of	of	ADP
fnp-2615	181	15	pleckstrin	pleckstrin	PROPN
fnp-2615	181	16	homology	homology	NOUN
fnp-2615	181	17	and	and	CCONJ
fnp-2615	181	18	rhogef	rhogef	VERB
fnp-2615	181	19	domain	domain	NOUN
fnp-2615	181	20	-	-	PUNCT
fnp-2615	181	21	containing	contain	VERB
fnp-2615	181	22	family	family	NOUN
fnp-2615	181	23	g	g	PROPN
fnp-2615	181	24	member	member	NOUN
fnp-2615	181	25	1	1	NUM
fnp-2615	181	26	gene	gene	NOUN
fnp-2615	181	27	(	(	PUNCT
fnp-2615	181	28	plekhg1	plekhg1	PROPN
fnp-2615	181	29	)	)	PUNCT
fnp-2615	181	30	associated	associate	VERB
fnp-2615	181	31	with	with	ADP
fnp-2615	181	32	white	white	ADJ
fnp-2615	181	33	matter	matter	NOUN
fnp-2615	181	34	hyperintensities	hyperintensitie	NOUN
fnp-2615	181	35	.	.	PUNCT
fnp-2615	182	1	the	the	DET
fnp-2615	182	2	association	association	NOUN
fnp-2615	182	3	was	be	AUX
fnp-2615	182	4	validated	validate	VERB
fnp-2615	182	5	in	in	ADP
fnp-2615	182	6	an	an	DET
fnp-2615	182	7	independent	independent	ADJ
fnp-2615	182	8	cohort	cohort	NOUN
fnp-2615	182	9	where	where	SCONJ
fnp-2615	182	10	this	this	DET
fnp-2615	182	11	polymorphism	polymorphism	NOUN
fnp-2615	182	12	was	be	AUX
fnp-2615	182	13	related	relate	VERB
fnp-2615	182	14	with	with	ADP
fnp-2615	182	15	ischemic	ischemic	ADJ
fnp-2615	182	16	strokes	stroke	NOUN
fnp-2615	182	17	.	.	PUNCT
fnp-2615	183	1	the	the	DET
fnp-2615	183	2	strongest	strong	ADJ
fnp-2615	183	3	association	association	NOUN
fnp-2615	183	4	was	be	AUX
fnp-2615	183	5	found	find	VERB
fnp-2615	183	6	with	with	ADP
fnp-2615	183	7	small	small	ADJ
fnp-2615	183	8	vessel	vessel	NOUN
fnp-2615	183	9	stroke	stroke	NOUN
fnp-2615	183	10	.	.	PUNCT
fnp-2615	184	1	plekhg1	plekhg1	NOUN
fnp-2615	184	2	plays	play	VERB
fnp-2615	184	3	a	a	DET
fnp-2615	184	4	role	role	NOUN
fnp-2615	184	5	in	in	ADP
fnp-2615	184	6	vascular	vascular	ADJ
fnp-2615	184	7	endothelial	endothelial	ADJ
fnp-2615	184	8	cell	cell	NOUN
fnp-2615	184	9	reorientation	reorientation	NOUN
fnp-2615	184	10	in	in	ADP
fnp-2615	184	11	response	response	NOUN
fnp-2615	184	12	to	to	ADP
fnp-2615	184	13	mechanical	mechanical	ADJ
fnp-2615	184	14	stress	stress	NOUN
fnp-2615	184	15	.	.	PUNCT
fnp-2615	185	1	therefore	therefore	ADV
fnp-2615	185	2	,	,	PUNCT
fnp-2615	185	3	the	the	DET
fnp-2615	185	4	polymorphism	polymorphism	NOUN
fnp-2615	185	5	in	in	ADP
fnp-2615	185	6	this	this	DET
fnp-2615	185	7	gene	gene	NOUN
fnp-2615	185	8	could	could	AUX
fnp-2615	185	9	generate	generate	VERB
fnp-2615	185	10	some	some	DET
fnp-2615	185	11	form	form	NOUN
fnp-2615	185	12	of	of	ADP
fnp-2615	185	13	vascular	vascular	ADJ
fnp-2615	185	14	alteration	alteration	NOUN
fnp-2615	185	15	leading	lead	VERB
fnp-2615	185	16	to	to	ADP
fnp-2615	185	17	the	the	DET
fnp-2615	185	18	development	development	NOUN
fnp-2615	185	19	of	of	ADP
fnp-2615	185	20	white	white	ADJ
fnp-2615	185	21	matter	matter	PROPN
fnp-2615	185	22	hyperintensities	hyperintensitie	NOUN
fnp-2615	185	23	.	.	PUNCT
fnp-2615	186	1	this	this	DET
fnp-2615	186	2	study	study	NOUN
fnp-2615	186	3	also	also	ADV
fnp-2615	186	4	validated	validate	VERB
fnp-2615	186	5	2	2	NUM
fnp-2615	186	6	previously	previously	ADV
fnp-2615	186	7	identified	identify	VERB
fnp-2615	186	8	genes	gene	NOUN
fnp-2615	186	9	efemp1	efemp1	NOUN
fnp-2615	186	10	and	and	CCONJ
fnp-2615	186	11	trim47	trim47	ADJ
fnp-2615	186	12	/	/	SYM
fnp-2615	186	13	trim65	trim65	NOUN
fnp-2615	186	14	.	.	PUNCT
fnp-2615	187	1	according	accord	VERB
fnp-2615	187	2	to	to	ADP
fnp-2615	187	3	current	current	ADJ
fnp-2615	187	4	knowledge	knowledge	NOUN
fnp-2615	187	5	,	,	PUNCT
fnp-2615	187	6	efemp1	efemp1	NOUN
fnp-2615	187	7	encodes	encode	VERB
fnp-2615	187	8	the	the	DET
fnp-2615	187	9	fibulin3	fibulin3	NOUN
fnp-2615	187	10	protein	protein	NOUN
fnp-2615	187	11	,	,	PUNCT
fnp-2615	187	12	which	which	PRON
fnp-2615	187	13	is	be	AUX
fnp-2615	187	14	an	an	DET
fnp-2615	187	15	extracellular	extracellular	ADJ
fnp-2615	187	16	matrix	matrix	NOUN
fnp-2615	187	17	glycoprotein	glycoprotein	NOUN
fnp-2615	187	18	that	that	PRON
fnp-2615	187	19	inhibits	inhibit	VERB
fnp-2615	187	20	timp3	timp3	NOUN
fnp-2615	187	21	.	.	PUNCT
fnp-2615	188	1	timp3	timp3	NOUN
fnp-2615	188	2	contributes	contribute	VERB
fnp-2615	188	3	to	to	PART
fnp-2615	188	4	cerebrovascular	cerebrovascular	ADJ
fnp-2615	188	5	dysfunction	dysfunction	NOUN
fnp-2615	188	6	in	in	ADP
fnp-2615	188	7	cadasil	cadasil	NOUN
fnp-2615	188	8	through	through	ADP
fnp-2615	188	9	accumulation	accumulation	NOUN
fnp-2615	188	10	in	in	ADP
fnp-2615	188	11	the	the	DET
fnp-2615	188	12	vascular	vascular	ADJ
fnp-2615	188	13	extracellular	extracellular	ADJ
fnp-2615	188	14	matrix	matrix	NOUN
fnp-2615	188	15	.	.	PUNCT
fnp-2615	189	1	therefore	therefore	ADV
fnp-2615	189	2	,	,	PUNCT
fnp-2615	189	3	there	there	PRON
fnp-2615	189	4	seems	seem	VERB
fnp-2615	189	5	to	to	PART
fnp-2615	189	6	be	be	AUX
fnp-2615	189	7	some	some	DET
fnp-2615	189	8	concordance	concordance	NOUN
fnp-2615	189	9	between	between	ADP
fnp-2615	189	10	genetic	genetic	ADJ
fnp-2615	189	11	alterations	alteration	NOUN
fnp-2615	189	12	in	in	ADP
fnp-2615	189	13	sporadic	sporadic	ADJ
fnp-2615	189	14	small	small	ADJ
fnp-2615	189	15	vessel	vessel	NOUN
fnp-2615	189	16	disease	disease	NOUN
fnp-2615	189	17	and	and	CCONJ
fnp-2615	189	18	the	the	DET
fnp-2615	189	19	monogenic	monogenic	ADJ
fnp-2615	189	20	form	form	NOUN
fnp-2615	189	21	of	of	ADP
fnp-2615	189	22	cadasil	cadasil	PROPN
fnp-2615	189	23	.	.	PUNCT
fnp-2615	190	1	based	base	VERB
fnp-2615	190	2	on	on	ADP
fnp-2615	190	3	the	the	DET
fnp-2615	190	4	concept	concept	NOUN
fnp-2615	190	5	that	that	SCONJ
fnp-2615	190	6	polymorphisms	polymorphism	NOUN
fnp-2615	190	7	in	in	ADP
fnp-2615	190	8	genes	gene	NOUN
fnp-2615	190	9	involved	involve	VERB
fnp-2615	190	10	in	in	ADP
fnp-2615	190	11	monogenic	monogenic	ADJ
fnp-2615	190	12	forms	form	NOUN
fnp-2615	190	13	of	of	ADP
fnp-2615	190	14	small	small	ADJ
fnp-2615	190	15	vessel	vessel	NOUN
fnp-2615	190	16	disease	disease	NOUN
fnp-2615	190	17	may	may	AUX
fnp-2615	190	18	have	have	AUX
fnp-2615	190	19	some	some	DET
fnp-2615	190	20	contribution	contribution	NOUN
fnp-2615	190	21	in	in	ADP
fnp-2615	190	22	the	the	DET
fnp-2615	190	23	sporadic	sporadic	ADJ
fnp-2615	190	24	form	form	NOUN
fnp-2615	190	25	of	of	ADP
fnp-2615	190	26	the	the	DET
fnp-2615	190	27	disease	disease	NOUN
fnp-2615	190	28	,	,	PUNCT
fnp-2615	190	29	mishra	mishra	PROPN
fnp-2615	190	30	et	et	PROPN
fnp-2615	190	31	al	al	PROPN
fnp-2615	190	32	.	.	PROPN
fnp-2615	191	1	(	(	PUNCT
fnp-2615	191	2	2019	2019	NUM
fnp-2615	191	3	)	)	PUNCT
fnp-2615	191	4	carried	carry	VERB
fnp-2615	191	5	out	out	ADP
fnp-2615	191	6	the	the	DET
fnp-2615	191	7	first	first	ADJ
fnp-2615	191	8	whole	whole	ADJ
fnp-2615	191	9	exome	exome	NOUN
fnp-2615	191	10	sequencing	sequence	VERB
fnp-2615	191	11	study	study	NOUN
fnp-2615	191	12	on	on	ADP
fnp-2615	191	13	mri	mri	NOUN
fnp-2615	191	14	white	white	PROPN
fnp-2615	191	15	matter	matter	NOUN
fnp-2615	191	16	hyperintensities	hyperintensitie	NOUN
fnp-2615	191	17	in	in	ADP
fnp-2615	191	18	small	small	ADJ
fnp-2615	191	19	vessel	vessel	NOUN
fnp-2615	191	20	disease	disease	NOUN
fnp-2615	191	21	.	.	PUNCT
fnp-2615	192	1	this	this	DET
fnp-2615	192	2	work	work	NOUN
fnp-2615	192	3	used	use	VERB
fnp-2615	192	4	a	a	DET
fnp-2615	192	5	composite	composite	ADJ
fnp-2615	192	6	extreme	extreme	ADJ
fnp-2615	192	7	phenotype	phenotype	NOUN
fnp-2615	192	8	study	study	NOUN
fnp-2615	192	9	focused	focus	VERB
fnp-2615	192	10	on	on	ADP
fnp-2615	192	11	candidate	candidate	NOUN
fnp-2615	192	12	genes	gene	NOUN
fnp-2615	192	13	with	with	ADP
fnp-2615	192	14	mutations	mutation	NOUN
fnp-2615	192	15	causing	cause	VERB
fnp-2615	192	16	mendelian	mendelian	ADJ
fnp-2615	192	17	heritable	heritable	ADJ
fnp-2615	192	18	forms	form	NOUN
fnp-2615	192	19	of	of	ADP
fnp-2615	192	20	small	small	ADJ
fnp-2615	192	21	vessel	vessel	NOUN
fnp-2615	192	22	disease	disease	NOUN
fnp-2615	192	23	,	,	PUNCT
fnp-2615	192	24	i.e.	i.e.	X
fnp-2615	192	25	notch3	notch3	PROPN
fnp-2615	192	26	,	,	PUNCT
fnp-2615	192	27	htra1	htra1	PROPN
fnp-2615	192	28	,	,	PUNCT
fnp-2615	192	29	col4a1	col4a1	PROPN
fnp-2615	192	30	,	,	PUNCT
fnp-2615	192	31	col4a2	col4a2	NOUN
fnp-2615	192	32	and	and	CCONJ
fnp-2615	192	33	trex1	trex1	PROPN
fnp-2615	192	34	.	.	PUNCT
fnp-2615	193	1	the	the	DET
fnp-2615	193	2	study	study	NOUN
fnp-2615	193	3	identified	identify	VERB
fnp-2615	193	4	significant	significant	ADJ
fnp-2615	193	5	associations	association	NOUN
fnp-2615	193	6	of	of	ADP
fnp-2615	193	7	gene	gene	NOUN
fnp-2615	193	8	variants	variant	NOUN
fnp-2615	193	9	in	in	ADP
fnp-2615	193	10	htra1	htra1	NOUN
fnp-2615	193	11	and	and	CCONJ
fnp-2615	193	12	notch3	notch3	PROPN
fnp-2615	193	13	with	with	ADP
fnp-2615	193	14	the	the	DET
fnp-2615	193	15	development	development	NOUN
fnp-2615	193	16	of	of	ADP
fnp-2615	193	17	white	white	ADJ
fnp-2615	193	18	matter	matter	NOUN
fnp-2615	193	19	hyperintensities	hyperintensitie	NOUN
fnp-2615	193	20	.	.	PUNCT
fnp-2615	194	1	overall	overall	ADJ
fnp-2615	194	2	the	the	DET
fnp-2615	194	3	study	study	NOUN
fnp-2615	194	4	demonstrates	demonstrate	VERB
fnp-2615	194	5	shared	share	VERB
fnp-2615	194	6	mechanisms	mechanism	NOUN
fnp-2615	194	7	between	between	ADP
fnp-2615	194	8	monogenic	monogenic	ADJ
fnp-2615	194	9	forms	form	NOUN
fnp-2615	194	10	and	and	CCONJ
fnp-2615	194	11	multifactorial	multifactorial	ADJ
fnp-2615	194	12	forms	form	NOUN
fnp-2615	194	13	of	of	ADP
fnp-2615	194	14	small	small	ADJ
fnp-2615	194	15	vessel	vessel	NOUN
fnp-2615	194	16	disease	disease	NOUN
fnp-2615	194	17	.	.	PUNCT
fnp-2615	195	1	the	the	DET
fnp-2615	195	2	study	study	NOUN
fnp-2615	195	3	suggested	suggest	VERB
fnp-2615	195	4	that	that	SCONJ
fnp-2615	195	5	the	the	DET
fnp-2615	195	6	risk	risk	NOUN
fnp-2615	195	7	htra1	htra1	NOUN
fnp-2615	195	8	allele	allele	NOUN
fnp-2615	195	9	reduced	reduce	VERB
fnp-2615	195	10	htra1	htra1	NOUN
fnp-2615	195	11	expression	expression	NOUN
fnp-2615	195	12	.	.	PUNCT
fnp-2615	196	1	mutations	mutation	NOUN
fnp-2615	196	2	in	in	ADP
fnp-2615	196	3	htra1	htra1	NOUN
fnp-2615	196	4	are	be	AUX
fnp-2615	196	5	associated	associate	VERB
fnp-2615	196	6	with	with	ADP
fnp-2615	196	7	cerebral	cerebral	ADJ
fnp-2615	196	8	autosomal	autosomal	ADJ
fnp-2615	196	9	recessive	recessive	ADJ
fnp-2615	196	10	arteriopathy	arteriopathy	NOUN
fnp-2615	196	11	with	with	ADP
fnp-2615	196	12	subcortical	subcortical	ADJ
fnp-2615	196	13	infarcts	infarct	NOUN
fnp-2615	196	14	and	and	CCONJ
fnp-2615	196	15	leukoencephalopathy	leukoencephalopathy	ADJ
fnp-2615	196	16	,	,	PUNCT
fnp-2615	196	17	carasil	carasil	NOUN
fnp-2615	196	18	,	,	PUNCT
fnp-2615	196	19	a	a	DET
fnp-2615	196	20	condition	condition	NOUN
fnp-2615	196	21	inherited	inherit	VERB
fnp-2615	196	22	in	in	ADP
fnp-2615	196	23	an	an	DET
fnp-2615	196	24	autosomal	autosomal	ADJ
fnp-2615	196	25	recessive	recessive	ADJ
fnp-2615	196	26	pattern	pattern	NOUN
fnp-2615	196	27	.	.	PUNCT
fnp-2615	197	1	htra1	htra1	PROPN
fnp-2615	197	2	is	be	AUX
fnp-2615	197	3	a	a	DET
fnp-2615	197	4	serine	serine	NOUN
fnp-2615	197	5	-	-	PUNCT
fnp-2615	197	6	protease	protease	NOUN
fnp-2615	197	7	involved	involve	VERB
fnp-2615	197	8	in	in	ADP
fnp-2615	197	9	cleaving	cleave	VERB
fnp-2615	197	10	extracellular	extracellular	ADJ
fnp-2615	197	11	matrix	matrix	NOUN
fnp-2615	197	12	proteins	protein	NOUN
fnp-2615	197	13	,	,	PUNCT
fnp-2615	197	14	including	include	VERB
fnp-2615	197	15	fibulin3	fibulin3	PROPN
fnp-2615	197	16	,	,	PUNCT
fnp-2615	197	17	and	and	CCONJ
fnp-2615	197	18	regulating	regulate	VERB
fnp-2615	197	19	important	important	ADJ
fnp-2615	197	20	signaling	signal	VERB
fnp-2615	197	21	pathways	pathway	NOUN
fnp-2615	197	22	such	such	ADJ
fnp-2615	197	23	as	as	ADP
fnp-2615	197	24	the	the	DET
fnp-2615	197	25	insulin	insulin	NOUN
fnp-2615	197	26	growth	growth	NOUN
fnp-2615	197	27	factor	factor	NOUN
fnp-2615	197	28	and	and	CCONJ
fnp-2615	197	29	tgfß	tgfß	NOUN
fnp-2615	197	30	pathway	pathway	NOUN
fnp-2615	197	31	,	,	PUNCT
fnp-2615	197	32	which	which	PRON
fnp-2615	197	33	suffers	suffer	VERB
fnp-2615	197	34	an	an	DET
fnp-2615	197	35	inhibitory	inhibitory	ADJ
fnp-2615	197	36	effect	effect	NOUN
fnp-2615	197	37	.	.	PUNCT
fnp-2615	198	1	notably	notably	ADV
fnp-2615	198	2	,	,	PUNCT
fnp-2615	198	3	htra1	htra1	PROPN
fnp-2615	198	4	is	be	AUX
fnp-2615	198	5	differentially	differentially	ADV
fnp-2615	198	6	expressed	express	VERB
fnp-2615	198	7	in	in	ADP
fnp-2615	198	8	astrocytes	astrocyte	NOUN
fnp-2615	198	9	(	(	PUNCT
fnp-2615	198	10	chen	chen	PROPN
fnp-2615	198	11	et	et	PROPN
fnp-2615	198	12	al	al	PROPN
fnp-2615	198	13	.	.	PROPN
fnp-2615	198	14	,	,	PUNCT
fnp-2615	198	15	2018	2018	NUM
fnp-2615	198	16	)	)	PUNCT
fnp-2615	198	17	suggesting	suggest	VERB
fnp-2615	198	18	that	that	SCONJ
fnp-2615	198	19	dysfunction	dysfunction	NOUN
fnp-2615	198	20	of	of	ADP
fnp-2615	198	21	this	this	DET
fnp-2615	198	22	pathway	pathway	NOUN
fnp-2615	198	23	may	may	AUX
fnp-2615	198	24	alter	alter	VERB
fnp-2615	198	25	astrocyte	astrocyte	NOUN
fnp-2615	198	26	function	function	NOUN
fnp-2615	198	27	leading	lead	VERB
fnp-2615	198	28	to	to	ADP
fnp-2615	198	29	compromised	compromise	VERB
fnp-2615	198	30	integrity	integrity	NOUN
fnp-2615	198	31	of	of	ADP
fnp-2615	198	32	the	the	DET
fnp-2615	198	33	neurovascular	neurovascular	ADJ
fnp-2615	198	34	unit	unit	NOUN
fnp-2615	198	35	and	and	CCONJ
fnp-2615	198	36	the	the	DET
fnp-2615	198	37	bbb	bbb	PROPN
fnp-2615	198	38	.	.	PUNCT
fnp-2615	199	1	hopefully	hopefully	ADV
fnp-2615	199	2	additional	additional	ADJ
fnp-2615	199	3	studies	study	NOUN
fnp-2615	199	4	using	use	VERB
fnp-2615	199	5	ipsc	ipsc	NOUN
fnp-2615	199	6	from	from	ADP
fnp-2615	199	7	patients	patient	NOUN
fnp-2615	199	8	and	and	CCONJ
fnp-2615	199	9	genetically	genetically	ADV
fnp-2615	199	10	modified	modify	VERB
fnp-2615	199	11	animal	animal	NOUN
fnp-2615	199	12	models	model	NOUN
fnp-2615	199	13	further	far	ADV
fnp-2615	199	14	investigating	investigate	VERB
fnp-2615	199	15	molecular	molecular	ADJ
fnp-2615	199	16	targets	target	NOUN
fnp-2615	199	17	identified	identify	VERB
fnp-2615	199	18	in	in	ADP
fnp-2615	199	19	prior	prior	ADJ
fnp-2615	199	20	genetic	genetic	ADJ
fnp-2615	199	21	studies	study	NOUN
fnp-2615	199	22	will	will	AUX
fnp-2615	199	23	lead	lead	VERB
fnp-2615	199	24	to	to	ADP
fnp-2615	199	25	the	the	DET
fnp-2615	199	26	discovery	discovery	NOUN
fnp-2615	199	27	of	of	ADP
fnp-2615	199	28	treatments	treatment	NOUN
fnp-2615	199	29	to	to	PART
fnp-2615	199	30	prevent	prevent	VERB
fnp-2615	199	31	and	and	CCONJ
fnp-2615	199	32	attenuate	attenuate	VERB
fnp-2615	199	33	the	the	DET
fnp-2615	199	34	progression	progression	NOUN
fnp-2615	199	35	of	of	ADP
fnp-2615	199	36	small	small	ADJ
fnp-2615	199	37	vessel	vessel	NOUN
fnp-2615	199	38	disease	disease	NOUN
fnp-2615	199	39	.	.	PUNCT
fnp-2615	200	1	figure	figure	NOUN
fnp-2615	200	2	2	2	NUM
fnp-2615	200	3	.	.	PUNCT
fnp-2615	201	1	lacunar	lacunar	PROPN
fnp-2615	201	2	infarcts	infarct	VERB
fnp-2615	201	3	typical	typical	ADJ
fnp-2615	201	4	of	of	ADP
fnp-2615	201	5	small	small	ADJ
fnp-2615	201	6	vessel	vessel	NOUN
fnp-2615	201	7	disease	disease	NOUN
fnp-2615	201	8	.	.	PUNCT
fnp-2615	202	1	a	a	DET
fnp-2615	202	2	)	)	PUNCT
fnp-2615	202	3	human	human	ADJ
fnp-2615	202	4	brain	brain	NOUN
fnp-2615	202	5	tissue	tissue	NOUN
fnp-2615	202	6	showing	show	VERB
fnp-2615	202	7	a	a	DET
fnp-2615	202	8	lacunar	lacunar	ADJ
fnp-2615	202	9	infarct	infarct	NOUN
fnp-2615	202	10	(	(	PUNCT
fnp-2615	202	11	arrow	arrow	NOUN
fnp-2615	202	12	)	)	PUNCT
fnp-2615	202	13	in	in	ADP
fnp-2615	202	14	the	the	DET
fnp-2615	202	15	centrum	centrum	PROPN
fnp-2615	202	16	semiovale	semiovale	NOUN
fnp-2615	202	17	.	.	PUNCT
fnp-2615	203	1	image	image	NOUN
fnp-2615	203	2	obtained	obtain	VERB
fnp-2615	203	3	by	by	ADP
fnp-2615	203	4	dr	dr	PROPN
fnp-2615	203	5	.	.	PROPN
fnp-2615	203	6	iban	iban	PROPN
fnp-2615	203	7	aldecoa	aldecoa	PROPN
fnp-2615	203	8	,	,	PUNCT
fnp-2615	203	9	neurological	neurological	ADJ
fnp-2615	203	10	tissue	tissue	NOUN
fnp-2615	203	11	bank	bank	NOUN
fnp-2615	203	12	of	of	ADP
fnp-2615	203	13	the	the	DET
fnp-2615	203	14	biobank	biobank	NOUN
fnp-2615	203	15	of	of	ADP
fnp-2615	203	16	hospital	hospital	NOUN
fnp-2615	203	17	clínic	clínic	ADJ
fnp-2615	203	18	idibaps	idibap	NOUN
fnp-2615	203	19	university	university	PROPN
fnp-2615	203	20	of	of	ADP
fnp-2615	203	21	barcelona	barcelona	PROPN
fnp-2615	203	22	.	.	PUNCT
fnp-2615	204	1	b	b	X
fnp-2615	204	2	)	)	PUNCT
fnp-2615	204	3	mri	mri	NOUN
fnp-2615	204	4	showing	show	VERB
fnp-2615	204	5	a	a	DET
fnp-2615	204	6	thalamic	thalamic	ADJ
fnp-2615	204	7	lacunar	lacunar	NOUN
fnp-2615	204	8	infarct	infarct	NOUN
fnp-2615	204	9	(	(	PUNCT
fnp-2615	204	10	arrow	arrow	NOUN
fnp-2615	204	11	)	)	PUNCT
fnp-2615	204	12	and	and	CCONJ
fnp-2615	204	13	c	c	X
fnp-2615	204	14	)	)	PUNCT
fnp-2615	204	15	corresponding	correspond	VERB
fnp-2615	204	16	ct	ct	PROPN
fnp-2615	204	17	-	-	PUNCT
fnp-2615	204	18	perfusion	perfusion	NOUN
fnp-2615	204	19	time	time	NOUN
fnp-2615	204	20	-	-	PUNCT
fnp-2615	204	21	to	to	ADP
fnp-2615	204	22	-	-	PUNCT
fnp-2615	204	23	drain	drain	NOUN
fnp-2615	204	24	(	(	PUNCT
fnp-2615	204	25	ttd	ttd	NOUN
fnp-2615	204	26	)	)	PUNCT
fnp-2615	204	27	image	image	NOUN
fnp-2615	204	28	obtained	obtain	VERB
fnp-2615	204	29	in	in	ADP
fnp-2615	204	30	the	the	DET
fnp-2615	204	31	acute	acute	ADJ
fnp-2615	204	32	phase	phase	NOUN
fnp-2615	204	33	showing	show	VERB
fnp-2615	204	34	a	a	DET
fnp-2615	204	35	delay	delay	NOUN
fnp-2615	204	36	in	in	ADP
fnp-2615	204	37	blood	blood	NOUN
fnp-2615	204	38	flow	flow	NOUN
fnp-2615	204	39	in	in	ADP
fnp-2615	204	40	the	the	DET
fnp-2615	204	41	lacunar	lacunar	ADJ
fnp-2615	204	42	infarction	infarction	NOUN
fnp-2615	204	43	(	(	PUNCT
fnp-2615	204	44	arrow	arrow	NOUN
fnp-2615	204	45	)	)	PUNCT
fnp-2615	204	46	.	.	PUNCT
fnp-2615	205	1	images	image	NOUN
fnp-2615	205	2	in	in	ADP
fnp-2615	205	3	b	b	NOUN
fnp-2615	205	4	and	and	CCONJ
fnp-2615	205	5	c	c	PROPN
fnp-2615	205	6	were	be	AUX
fnp-2615	205	7	obtained	obtain	VERB
fnp-2615	205	8	in	in	ADP
fnp-2615	205	9	the	the	DET
fnp-2615	205	10	comprehensive	comprehensive	ADJ
fnp-2615	205	11	stroke	stroke	NOUN
fnp-2615	205	12	center	center	PROPN
fnp-2615	205	13	of	of	ADP
fnp-2615	205	14	hospital	hospital	NOUN
fnp-2615	205	15	clinic	clinic	PROPN
fnp-2615	205	16	of	of	ADP
fnp-2615	205	17	barcelona	barcelona	PROPN
fnp-2615	205	18	.	.	PUNCT
fnp-2615	206	1	8	8	NUM
fnp-2615	206	2	.	.	PUNCT
fnp-2615	206	3	cerebral	cerebral	ADJ
fnp-2615	206	4	hypoperfusion	hypoperfusion	NOUN
fnp-2615	206	5	and	and	CCONJ
fnp-2615	206	6	vascular	vascular	ADJ
fnp-2615	206	7	cognitive	cognitive	ADJ
fnp-2615	206	8	impairment	impairment	NOUN
fnp-2615	206	9	:	:	PUNCT
fnp-2615	206	10	risks	risk	NOUN
fnp-2615	206	11	of	of	ADP
fnp-2615	206	12	high	high	ADJ
fnp-2615	206	13	-	-	PUNCT
fnp-2615	206	14	salt	salt	NOUN
fnp-2615	206	15	diet	diet	NOUN
fnp-2615	206	16	chronic	chronic	ADJ
fnp-2615	206	17	cerebral	cerebral	ADJ
fnp-2615	206	18	hypoperfusion	hypoperfusion	NOUN
fnp-2615	206	19	has	have	AUX
fnp-2615	206	20	been	be	AUX
fnp-2615	206	21	associated	associate	VERB
fnp-2615	206	22	with	with	ADP
fnp-2615	206	23	diffuse	diffuse	PROPN
fnp-2615	206	24	white	white	ADJ
fnp-2615	206	25	matter	matter	NOUN
fnp-2615	206	26	damage	damage	NOUN
fnp-2615	206	27	and	and	CCONJ
fnp-2615	206	28	cognitive	cognitive	ADJ
fnp-2615	206	29	impairment	impairment	NOUN
fnp-2615	206	30	of	of	ADP
fnp-2615	206	31	vascular	vascular	ADJ
fnp-2615	206	32	origin	origin	NOUN
fnp-2615	206	33	.	.	PUNCT
fnp-2615	207	1	vascular	vascular	ADJ
fnp-2615	207	2	pathology	pathology	NOUN
fnp-2615	207	3	is	be	AUX
fnp-2615	207	4	also	also	ADV
fnp-2615	207	5	frequently	frequently	ADV
fnp-2615	207	6	observed	observe	VERB
fnp-2615	207	7	in	in	ADP
fnp-2615	207	8	neurodegenerative	neurodegenerative	ADJ
fnp-2615	207	9	dementias	dementia	NOUN
fnp-2615	207	10	.	.	PUNCT
fnp-2615	208	1	hase	hase	VERB
fnp-2615	208	2	et	et	PROPN
fnp-2615	208	3	al	al	PROPN
fnp-2615	208	4	.	.	PROPN
fnp-2615	209	1	(	(	PUNCT
fnp-2615	209	2	2019	2019	NUM
fnp-2615	209	3	)	)	PUNCT
fnp-2615	209	4	investigated	investigate	VERB
fnp-2615	209	5	the	the	DET
fnp-2615	209	6	histopathologic	histopathologic	NOUN
fnp-2615	209	7	features	feature	NOUN
fnp-2615	209	8	of	of	ADP
fnp-2615	209	9	white	white	ADJ
fnp-2615	209	10	matter	matter	NOUN
fnp-2615	209	11	capillaries	capillary	NOUN
fnp-2615	209	12	by	by	ADP
fnp-2615	209	13	studying	study	VERB
fnp-2615	209	14	approximately	approximately	ADV
fnp-2615	209	15	0.7	0.7	NUM
fnp-2615	209	16	million	million	NUM
fnp-2615	209	17	capillary	capillary	ADJ
fnp-2615	209	18	profiles	profile	NOUN
fnp-2615	209	19	from	from	ADP
fnp-2615	209	20	the	the	DET
fnp-2615	209	21	frontal	frontal	ADJ
fnp-2615	209	22	lobe	lobe	VERB
fnp-2615	209	23	white	white	ADJ
fnp-2615	209	24	matter	matter	NOUN
fnp-2615	209	25	of	of	ADP
fnp-2615	209	26	153	153	NUM
fnp-2615	209	27	subjects	subject	NOUN
fnp-2615	209	28	with	with	ADP
fnp-2615	209	29	different	different	ADJ
fnp-2615	209	30	dementia	dementia	NOUN
fnp-2615	209	31	types	type	NOUN
fnp-2615	209	32	including	include	VERB
fnp-2615	209	33	alzheimer	alzheimer	PROPN
fnp-2615	209	34	’s	’s	PART
fnp-2615	209	35	disease	disease	NOUN
fnp-2615	209	36	,	,	PUNCT
fnp-2615	209	37	dementia	dementia	NOUN
fnp-2615	209	38	with	with	ADP
fnp-2615	209	39	lewy	lewy	PROPN
fnp-2615	209	40	bodies	body	NOUN
fnp-2615	209	41	,	,	PUNCT
fnp-2615	209	42	dementia	dementia	NOUN
fnp-2615	209	43	in	in	ADP
fnp-2615	209	44	parkinson	parkinson	NOUN
fnp-2615	209	45	’s	’s	PART
fnp-2615	209	46	disease	disease	NOUN
fnp-2615	209	47	,	,	PUNCT
fnp-2615	209	48	vascular	vascular	ADJ
fnp-2615	209	49	dementia	dementia	NOUN
fnp-2615	209	50	,	,	PUNCT
fnp-2615	209	51	mixed	mixed	ADJ
fnp-2615	209	52	dementia	dementia	NOUN
fnp-2615	209	53	,	,	PUNCT
fnp-2615	209	54	post	post	ADJ
fnp-2615	209	55	-	-	ADJ
fnp-2615	209	56	stroke	stroke	ADJ
fnp-2615	209	57	dementia	dementia	NOUN
fnp-2615	209	58	and	and	CCONJ
fnp-2615	209	59	post	post	ADJ
fnp-2615	209	60	-	-	ADJ
fnp-2615	209	61	stroke	stroke	ADJ
fnp-2615	209	62	no	no	DET
fnp-2615	209	63	dementia	dementia	NOUN
fnp-2615	209	64	.	.	PUNCT
fnp-2615	210	1	control	control	NOUN
fnp-2615	210	2	samples	sample	NOUN
fnp-2615	210	3	were	be	AUX
fnp-2615	210	4	examined	examine	VERB
fnp-2615	210	5	from	from	ADP
fnp-2615	210	6	old	old	ADJ
fnp-2615	210	7	and	and	CCONJ
fnp-2615	210	8	young	young	ADJ
fnp-2615	210	9	individuals	individual	NOUN
fnp-2615	210	10	devoid	devoid	ADJ
fnp-2615	210	11	of	of	ADP
fnp-2615	210	12	brain	brain	NOUN
fnp-2615	210	13	pathology	pathology	NOUN
fnp-2615	210	14	.	.	PUNCT
fnp-2615	211	1	all	all	DET
fnp-2615	211	2	dementias	dementia	NOUN
fnp-2615	211	3	showed	show	VERB
fnp-2615	211	4	higher	high	ADJ
fnp-2615	211	5	vascular	vascular	ADJ
fnp-2615	211	6	pathology	pathology	NOUN
fnp-2615	211	7	scores	score	NOUN
fnp-2615	211	8	than	than	ADP
fnp-2615	211	9	corresponding	correspond	VERB
fnp-2615	211	10	age	age	NOUN
fnp-2615	211	11	-	-	PUNCT
fnp-2615	211	12	matched	match	VERB
fnp-2615	211	13	controls	control	NOUN
fnp-2615	211	14	.	.	PUNCT
fnp-2615	212	1	in	in	ADP
fnp-2615	212	2	relation	relation	NOUN
fnp-2615	212	3	to	to	ADP
fnp-2615	212	4	these	these	DET
fnp-2615	212	5	controls	control	NOUN
fnp-2615	212	6	,	,	PUNCT
fnp-2615	212	7	white	white	ADJ
fnp-2615	212	8	matter	matter	NOUN
fnp-2615	212	9	lesion	lesion	NOUN
fnp-2615	212	10	scores	score	NOUN
fnp-2615	212	11	were	be	AUX
fnp-2615	212	12	also	also	ADV
fnp-2615	212	13	higher	high	ADJ
fnp-2615	212	14	in	in	ADP
fnp-2615	212	15	all	all	DET
fnp-2615	212	16	dementias	dementia	NOUN
fnp-2615	212	17	,	,	PUNCT
fnp-2615	212	18	with	with	ADP
fnp-2615	212	19	the	the	DET
fnp-2615	212	20	highest	high	ADJ
fnp-2615	212	21	values	value	NOUN
fnp-2615	212	22	corresponding	correspond	VERB
fnp-2615	212	23	to	to	ADP
fnp-2615	212	24	vascular	vascular	ADJ
fnp-2615	212	25	dementia	dementia	NOUN
fnp-2615	212	26	and	and	CCONJ
fnp-2615	212	27	post	post	ADJ
fnp-2615	212	28	-	-	ADJ
fnp-2615	212	29	stroke	stroke	ADJ
fnp-2615	212	30	dementia	dementia	NOUN
fnp-2615	212	31	.	.	PUNCT
fnp-2615	213	1	the	the	DET
fnp-2615	213	2	two	two	NUM
fnp-2615	213	3	latter	latter	ADJ
fnp-2615	213	4	conditions	condition	NOUN
fnp-2615	213	5	showed	show	VERB
fnp-2615	213	6	the	the	DET
fnp-2615	213	7	highest	high	ADJ
fnp-2615	213	8	abundance	abundance	NOUN
fnp-2615	213	9	of	of	ADP
fnp-2615	213	10	string	string	NOUN
fnp-2615	213	11	vessels	vessel	NOUN
fnp-2615	213	12	,	,	PUNCT
fnp-2615	213	13	which	which	PRON
fnp-2615	213	14	were	be	AUX
fnp-2615	213	15	observed	observe	VERB
fnp-2615	213	16	to	to	ADP
fnp-2615	213	17	a	a	DET
fnp-2615	213	18	lesser	less	ADJ
fnp-2615	213	19	extent	extent	NOUN
fnp-2615	213	20	in	in	ADP
fnp-2615	213	21	the	the	DET
fnp-2615	213	22	other	other	ADJ
fnp-2615	213	23	dementia	dementia	NOUN
fnp-2615	213	24	types	type	NOUN
fnp-2615	213	25	.	.	PUNCT
fnp-2615	214	1	the	the	DET
fnp-2615	214	2	density	density	NOUN
fnp-2615	214	3	of	of	ADP
fnp-2615	214	4	col4	col4	PROPN
fnp-2615	214	5	+	+	CCONJ
fnp-2615	214	6	and	and	CCONJ
fnp-2615	214	7	glut1	glut1	PROPN
fnp-2615	214	8	+	+	SYM
fnp-2615	214	9	capillaries	capillary	NOUN
fnp-2615	214	10	was	be	AUX
fnp-2615	214	11	lower	low	ADJ
fnp-2615	214	12	in	in	ADP
fnp-2615	214	13	the	the	DET
fnp-2615	214	14	white	white	ADJ
fnp-2615	214	15	matter	matter	NOUN
fnp-2615	214	16	than	than	ADP
fnp-2615	214	17	in	in	ADP
fnp-2615	214	18	the	the	DET
fnp-2615	214	19	cortex	cortex	NOUN
fnp-2615	214	20	and	and	CCONJ
fnp-2615	214	21	was	be	AUX
fnp-2615	214	22	also	also	ADV
fnp-2615	214	23	lower	low	ADJ
fnp-2615	214	24	in	in	ADP
fnp-2615	214	25	dementia	dementia	NOUN
fnp-2615	214	26	patients	patient	NOUN
fnp-2615	214	27	versus	versus	ADP
fnp-2615	214	28	aged	aged	ADJ
fnp-2615	214	29	controls	control	NOUN
fnp-2615	214	30	,	,	PUNCT
fnp-2615	214	31	with	with	ADP
fnp-2615	214	32	the	the	DET
fnp-2615	214	33	exception	exception	NOUN
fnp-2615	214	34	of	of	ADP
fnp-2615	214	35	individuals	individual	NOUN
fnp-2615	214	36	that	that	PRON
fnp-2615	214	37	had	have	AUX
fnp-2615	214	38	suffered	suffer	VERB
fnp-2615	214	39	a	a	DET
fnp-2615	214	40	stroke	stroke	NOUN
fnp-2615	214	41	.	.	PUNCT
fnp-2615	215	1	the	the	DET
fnp-2615	215	2	capillary	capillary	ADJ
fnp-2615	215	3	width	width	NOUN
fnp-2615	215	4	in	in	ADP
fnp-2615	215	5	the	the	DET
fnp-2615	215	6	white	white	ADJ
fnp-2615	215	7	matter	matter	NOUN
fnp-2615	215	8	was	be	AUX
fnp-2615	215	9	31	31	NUM
fnp-2615	215	10	%	%	NOUN
fnp-2615	215	11	greater	great	ADJ
fnp-2615	215	12	than	than	ADP
fnp-2615	215	13	in	in	ADP
fnp-2615	215	14	the	the	DET
fnp-2615	215	15	cortex	cortex	NOUN
fnp-2615	215	16	.	.	PUNCT
fnp-2615	216	1	notably	notably	ADV
fnp-2615	216	2	,	,	PUNCT
fnp-2615	216	3	white	white	ADJ
fnp-2615	216	4	matter	matter	NOUN
fnp-2615	216	5	capillaries	capillary	NOUN
fnp-2615	216	6	were	be	AUX
fnp-2615	216	7	wider	wide	ADJ
fnp-2615	216	8	in	in	ADP
fnp-2615	216	9	all	all	DET
fnp-2615	216	10	dementias	dementia	NOUN
fnp-2615	216	11	compared	compare	VERB
fnp-2615	216	12	to	to	ADP
fnp-2615	216	13	all	all	DET
fnp-2615	216	14	controls	control	NOUN
fnp-2615	216	15	irrespective	irrespective	ADV
fnp-2615	216	16	of	of	ADP
fnp-2615	216	17	age	age	NOUN
fnp-2615	216	18	.	.	PUNCT
fnp-2615	217	1	moreover	moreover	ADV
fnp-2615	217	2	,	,	PUNCT
fnp-2615	217	3	there	there	PRON
fnp-2615	217	4	was	be	VERB
fnp-2615	217	5	a	a	DET
fnp-2615	217	6	moderate	moderate	ADJ
fnp-2615	217	7	positive	positive	ADJ
fnp-2615	217	8	correlation	correlation	NOUN
fnp-2615	217	9	between	between	ADP
fnp-2615	217	10	capillary	capillary	ADJ
fnp-2615	217	11	width	width	NOUN
fnp-2615	217	12	and	and	CCONJ
fnp-2615	217	13	white	white	ADJ
fnp-2615	217	14	matter	matter	NOUN
fnp-2615	217	15	lesion	lesion	NOUN
fnp-2615	217	16	scores	score	NOUN
fnp-2615	217	17	.	.	PUNCT
fnp-2615	218	1	these	these	DET
fnp-2615	218	2	results	result	NOUN
fnp-2615	218	3	indicate	indicate	VERB
fnp-2615	218	4	adaptive	adaptive	ADJ
fnp-2615	218	5	compensatory	compensatory	ADJ
fnp-2615	218	6	mechanisms	mechanism	NOUN
fnp-2615	218	7	for	for	ADP
fnp-2615	218	8	chronic	chronic	ADJ
fnp-2615	218	9	hypoperfusion	hypoperfusion	NOUN
fnp-2615	218	10	in	in	ADP
fnp-2615	218	11	aging	age	VERB
fnp-2615	218	12	-	-	PUNCT
fnp-2615	218	13	related	relate	VERB
fnp-2615	218	14	dementias	dementia	NOUN
fnp-2615	218	15	.	.	PUNCT
fnp-2615	219	1	an	an	DET
fnp-2615	219	2	emerging	emerge	VERB
fnp-2615	219	3	risk	risk	NOUN
fnp-2615	219	4	factor	factor	NOUN
fnp-2615	219	5	recently	recently	ADV
fnp-2615	219	6	recognized	recognize	VERB
fnp-2615	219	7	as	as	ADP
fnp-2615	219	8	a	a	DET
fnp-2615	219	9	driver	driver	NOUN
fnp-2615	219	10	of	of	ADP
fnp-2615	219	11	cerebral	cerebral	ADJ
fnp-2615	219	12	vascular	vascular	ADJ
fnp-2615	219	13	dysfunction	dysfunction	NOUN
fnp-2615	219	14	and	and	CCONJ
fnp-2615	219	15	hypoperfusion	hypoperfusion	NOUN
fnp-2615	219	16	is	be	AUX
fnp-2615	219	17	high	high	ADJ
fnp-2615	219	18	-	-	PUNCT
fnp-2615	219	19	salt	salt	NOUN
fnp-2615	219	20	intake	intake	NOUN
fnp-2615	219	21	(	(	PUNCT
fnp-2615	219	22	faraco	faraco	PROPN
fnp-2615	219	23	et	et	PROPN
fnp-2615	219	24	al	al	PROPN
fnp-2615	219	25	.	.	PROPN
fnp-2615	219	26	,	,	PUNCT
fnp-2615	219	27	2018	2018	NUM
fnp-2615	219	28	)	)	PUNCT
fnp-2615	219	29	.	.	PUNCT
fnp-2615	220	1	interestingly	interestingly	ADV
fnp-2615	220	2	,	,	PUNCT
fnp-2615	220	3	the	the	DET
fnp-2615	220	4	underlying	underlying	ADJ
fnp-2615	220	5	mechanism	mechanism	NOUN
fnp-2615	220	6	is	be	AUX
fnp-2615	220	7	not	not	PART
fnp-2615	220	8	dependent	dependent	ADJ
fnp-2615	220	9	on	on	ADP
fnp-2615	220	10	salt	salt	NOUN
fnp-2615	220	11	-	-	PUNCT
fnp-2615	220	12	induced	induce	VERB
fnp-2615	220	13	hypertension	hypertension	NOUN
fnp-2615	220	14	but	but	CCONJ
fnp-2615	220	15	on	on	ADP
fnp-2615	220	16	a	a	DET
fnp-2615	220	17	complex	complex	ADJ
fnp-2615	220	18	innate	innate	ADJ
fnp-2615	220	19	immune	immune	ADJ
fnp-2615	220	20	response	response	NOUN
fnp-2615	220	21	mediated	mediate	VERB
fnp-2615	220	22	by	by	ADP
fnp-2615	220	23	alterations	alteration	NOUN
fnp-2615	220	24	in	in	ADP
fnp-2615	220	25	the	the	DET
fnp-2615	220	26	gut	gut	NOUN
fnp-2615	220	27	immune	immune	ADJ
fnp-2615	220	28	system	system	NOUN
fnp-2615	220	29	(	(	PUNCT
fnp-2615	220	30	faraco	faraco	PROPN
fnp-2615	220	31	et	et	PROPN
fnp-2615	220	32	al	al	PROPN
fnp-2615	220	33	.	.	PROPN
fnp-2615	220	34	,	,	PUNCT
fnp-2615	220	35	2018	2018	NUM
fnp-2615	220	36	)	)	PUNCT
fnp-2615	220	37	.	.	PUNCT
fnp-2615	221	1	last	last	ADJ
fnp-2615	221	2	year	year	NOUN
fnp-2615	221	3	,	,	PUNCT
fnp-2615	221	4	a	a	DET
fnp-2615	221	5	study	study	NOUN
fnp-2615	221	6	by	by	ADP
fnp-2615	221	7	the	the	DET
fnp-2615	221	8	same	same	ADJ
fnp-2615	221	9	team	team	NOUN
fnp-2615	221	10	reported	report	VERB
fnp-2615	221	11	that	that	SCONJ
fnp-2615	221	12	chronic	chronic	ADJ
fnp-2615	221	13	dietary	dietary	ADJ
fnp-2615	221	14	high	high	ADJ
fnp-2615	221	15	-	-	PUNCT
fnp-2615	221	16	salt	salt	NOUN
fnp-2615	221	17	intake	intake	NOUN
fnp-2615	221	18	in	in	ADP
fnp-2615	221	19	mice	mouse	NOUN
fnp-2615	221	20	promotes	promote	VERB
fnp-2615	221	21	cognitive	cognitive	ADJ
fnp-2615	221	22	impairment	impairment	NOUN
fnp-2615	221	23	by	by	ADP
fnp-2615	221	24	inducing	induce	VERB
fnp-2615	221	25	phosphorylation	phosphorylation	NOUN
fnp-2615	221	26	of	of	ADP
fnp-2615	221	27	the	the	DET
fnp-2615	221	28	microtubule	microtubule	NOUN
fnp-2615	221	29	-	-	PUNCT
fnp-2615	221	30	associated	associate	VERB
fnp-2615	221	31	protein	protein	NOUN
fnp-2615	221	32	tau	tau	PROPN
fnp-2615	221	33	rather	rather	ADV
fnp-2615	221	34	than	than	ADP
fnp-2615	221	35	by	by	ADP
fnp-2615	221	36	insufficient	insufficient	ADJ
fnp-2615	221	37	cerebral	cerebral	ADJ
fnp-2615	221	38	perfusion	perfusion	NOUN
fnp-2615	221	39	(	(	PUNCT
fnp-2615	221	40	faraco	faraco	PROPN
fnp-2615	221	41	et	et	PROPN
fnp-2615	221	42	al	al	PROPN
fnp-2615	221	43	.	.	PROPN
fnp-2615	221	44	,	,	PUNCT
fnp-2615	221	45	2019	2019	NUM
fnp-2615	221	46	)	)	PUNCT
fnp-2615	221	47	.	.	PUNCT
fnp-2615	222	1	the	the	DET
fnp-2615	222	2	presence	presence	NOUN
fnp-2615	222	3	of	of	ADP
fnp-2615	222	4	hyperphosphorylated	hyperphosphorylated	ADJ
fnp-2615	222	5	tau	tau	PROPN
fnp-2615	222	6	is	be	AUX
fnp-2615	222	7	one	one	NUM
fnp-2615	222	8	of	of	ADP
fnp-2615	222	9	the	the	DET
fnp-2615	222	10	hallmarks	hallmark	NOUN
fnp-2615	222	11	of	of	ADP
fnp-2615	222	12	alzheimer	alzheimer	PROPN
fnp-2615	222	13	’s	’s	PART
fnp-2615	222	14	disease	disease	NOUN
fnp-2615	222	15	that	that	PRON
fnp-2615	222	16	has	have	AUX
fnp-2615	222	17	also	also	ADV
fnp-2615	222	18	been	be	AUX
fnp-2615	222	19	reported	report	VERB
fnp-2615	222	20	in	in	ADP
fnp-2615	222	21	patients	patient	NOUN
fnp-2615	222	22	with	with	ADP
fnp-2615	222	23	vascular	vascular	ADJ
fnp-2615	222	24	cognitive	cognitive	ADJ
fnp-2615	222	25	impairment	impairment	NOUN
fnp-2615	222	26	.	.	PUNCT
fnp-2615	223	1	mice	mouse	NOUN
fnp-2615	223	2	exposed	expose	VERB
fnp-2615	223	3	to	to	ADP
fnp-2615	223	4	high	high	ADJ
fnp-2615	223	5	-	-	PUNCT
fnp-2615	223	6	salt	salt	NOUN
fnp-2615	223	7	diet	diet	NOUN
fnp-2615	223	8	for	for	ADP
fnp-2615	223	9	several	several	ADJ
fnp-2615	223	10	months	month	NOUN
fnp-2615	223	11	developed	develop	VERB
fnp-2615	223	12	signs	sign	NOUN
fnp-2615	223	13	of	of	ADP
fnp-2615	223	14	cognitive	cognitive	ADJ
fnp-2615	223	15	impairment	impairment	NOUN
fnp-2615	223	16	that	that	PRON
fnp-2615	223	17	correlated	correlate	VERB
fnp-2615	223	18	with	with	ADP
fnp-2615	223	19	the	the	DET
fnp-2615	223	20	phosphorylation	phosphorylation	NOUN
fnp-2615	223	21	and	and	CCONJ
fnp-2615	223	22	aggregation	aggregation	NOUN
fnp-2615	223	23	of	of	ADP
fnp-2615	223	24	tau	tau	PROPN
fnp-2615	223	25	in	in	ADP
fnp-2615	223	26	the	the	DET
fnp-2615	223	27	brain	brain	NOUN
fnp-2615	223	28	tissue	tissue	NOUN
fnp-2615	223	29	.	.	PUNCT
fnp-2615	224	1	through	through	ADP
fnp-2615	224	2	different	different	ADJ
fnp-2615	224	3	experimental	experimental	ADJ
fnp-2615	224	4	strategies	strategy	NOUN
fnp-2615	224	5	,	,	PUNCT
fnp-2615	224	6	the	the	DET
fnp-2615	224	7	study	study	NOUN
fnp-2615	224	8	demonstrated	demonstrate	VERB
fnp-2615	224	9	that	that	SCONJ
fnp-2615	224	10	high	high	ADJ
fnp-2615	224	11	-	-	PUNCT
fnp-2615	224	12	salt	salt	NOUN
fnp-2615	224	13	diet	diet	NOUN
fnp-2615	224	14	impaired	impair	VERB
fnp-2615	224	15	the	the	DET
fnp-2615	224	16	production	production	NOUN
fnp-2615	224	17	of	of	ADP
fnp-2615	224	18	endothelial	endothelial	ADJ
fnp-2615	224	19	nitric	nitric	ADJ
fnp-2615	224	20	oxide	oxide	NOUN
fnp-2615	224	21	following	follow	VERB
fnp-2615	224	22	denitrosylation	denitrosylation	NOUN
fnp-2615	224	23	of	of	ADP
fnp-2615	224	24	calpain	calpain	NOUN
fnp-2615	224	25	.	.	PUNCT
fnp-2615	225	1	deficient	deficient	ADJ
fnp-2615	225	2	nitric	nitric	ADJ
fnp-2615	225	3	oxide	oxide	NOUN
fnp-2615	225	4	generation	generation	NOUN
fnp-2615	225	5	activated	activate	VERB
fnp-2615	225	6	cyclin	cyclin	NOUN
fnp-2615	225	7	-	-	PUNCT
fnp-2615	225	8	dependent	dependent	ADJ
fnp-2615	225	9	kinase	kinase	NOUN
fnp-2615	225	10	5	5	NUM
fnp-2615	225	11	(	(	PUNCT
fnp-2615	225	12	cdk5	cdk5	PROPN
fnp-2615	225	13	)	)	PUNCT
fnp-2615	225	14	which	which	PRON
fnp-2615	225	15	caused	cause	VERB
fnp-2615	225	16	tau	tau	PROPN
fnp-2615	225	17	phosphorylation	phosphorylation	NOUN
fnp-2615	225	18	.	.	PUNCT
fnp-2615	226	1	although	although	SCONJ
fnp-2615	226	2	these	these	DET
fnp-2615	226	3	important	important	ADJ
fnp-2615	226	4	findings	finding	NOUN
fnp-2615	226	5	were	be	AUX
fnp-2615	226	6	obtained	obtain	VERB
fnp-2615	226	7	in	in	ADP
fnp-2615	226	8	mice	mouse	NOUN
fnp-2615	226	9	with	with	ADP
fnp-2615	226	10	unrealistically	unrealistically	ADV
fnp-2615	226	11	high	high	ADJ
fnp-2615	226	12	levels	level	NOUN
fnp-2615	226	13	of	of	ADP
fnp-2615	226	14	salt	salt	NOUN
fnp-2615	226	15	intake	intake	NOUN
fnp-2615	226	16	,	,	PUNCT
fnp-2615	226	17	the	the	DET
fnp-2615	226	18	study	study	NOUN
fnp-2615	226	19	identifies	identify	VERB
fnp-2615	226	20	a	a	DET
fnp-2615	226	21	causal	causal	ADJ
fnp-2615	226	22	relation	relation	NOUN
fnp-2615	226	23	between	between	ADP
fnp-2615	226	24	high	high	ADJ
fnp-2615	226	25	-	-	PUNCT
fnp-2615	226	26	salt	salt	NOUN
fnp-2615	226	27	intake	intake	NOUN
fnp-2615	226	28	,	,	PUNCT
fnp-2615	226	29	vascular	vascular	ADJ
fnp-2615	226	30	dysfunction	dysfunction	NOUN
fnp-2615	226	31	,	,	PUNCT
fnp-2615	226	32	tau	tau	PROPN
fnp-2615	226	33	pathology	pathology	NOUN
fnp-2615	226	34	,	,	PUNCT
fnp-2615	226	35	and	and	CCONJ
fnp-2615	226	36	cognitive	cognitive	ADJ
fnp-2615	226	37	impairment	impairment	NOUN
fnp-2615	226	38	independent	independent	ADJ
fnp-2615	226	39	of	of	ADP
fnp-2615	226	40	cerebral	cerebral	ADJ
fnp-2615	226	41	hypoperfusion	hypoperfusion	NOUN
fnp-2615	226	42	.	.	PUNCT
fnp-2615	227	1	9	9	X
fnp-2615	227	2	.	.	X
fnp-2615	227	3	critical	critical	ADJ
fnp-2615	227	4	role	role	NOUN
fnp-2615	227	5	of	of	ADP
fnp-2615	227	6	pericytes	pericyte	NOUN
fnp-2615	227	7	in	in	ADP
fnp-2615	227	8	bbb	bbb	PROPN
fnp-2615	227	9	function	function	NOUN
fnp-2615	227	10	and	and	CCONJ
fnp-2615	227	11	more	more	ADJ
fnp-2615	227	12	pericytes	pericyte	NOUN
fnp-2615	227	13	are	be	AUX
fnp-2615	227	14	mural	mural	ADJ
fnp-2615	227	15	cells	cell	NOUN
fnp-2615	227	16	surrounding	surround	VERB
fnp-2615	227	17	capillaries	capillary	NOUN
fnp-2615	227	18	that	that	PRON
fnp-2615	227	19	play	play	VERB
fnp-2615	227	20	essential	essential	ADJ
fnp-2615	227	21	functions	function	NOUN
fnp-2615	227	22	in	in	ADP
fnp-2615	227	23	development	development	NOUN
fnp-2615	227	24	and	and	CCONJ
fnp-2615	227	25	maintenance	maintenance	NOUN
fnp-2615	227	26	of	of	ADP
fnp-2615	227	27	bbb	bbb	PROPN
fnp-2615	227	28	integrity	integrity	NOUN
fnp-2615	227	29	.	.	PUNCT
fnp-2615	228	1	pericytes	pericyte	NOUN
fnp-2615	228	2	facilitate	facilitate	VERB
fnp-2615	228	3	molecular	molecular	ADJ
fnp-2615	228	4	pathways	pathway	NOUN
fnp-2615	228	5	critical	critical	ADJ
fnp-2615	228	6	in	in	ADP
fnp-2615	228	7	preventing	prevent	VERB
fnp-2615	228	8	vascular	vascular	ADJ
fnp-2615	228	9	malformations	malformation	NOUN
fnp-2615	228	10	,	,	PUNCT
fnp-2615	228	11	and	and	CCONJ
fnp-2615	228	12	it	it	PRON
fnp-2615	228	13	appears	appear	VERB
fnp-2615	228	14	that	that	SCONJ
fnp-2615	228	15	these	these	DET
fnp-2615	228	16	cells	cell	NOUN
fnp-2615	228	17	can	can	AUX
fnp-2615	228	18	generate	generate	VERB
fnp-2615	228	19	factors	factor	NOUN
fnp-2615	228	20	that	that	PRON
fnp-2615	228	21	directly	directly	ADV
fnp-2615	228	22	support	support	VERB
fnp-2615	228	23	neuronal	neuronal	ADJ
fnp-2615	228	24	viability	viability	NOUN
fnp-2615	228	25	.	.	PUNCT
fnp-2615	229	1	recent	recent	ADJ
fnp-2615	229	2	studies	study	NOUN
fnp-2615	229	3	have	have	AUX
fnp-2615	229	4	provided	provide	VERB
fnp-2615	229	5	valuable	valuable	ADJ
fnp-2615	229	6	information	information	NOUN
fnp-2615	229	7	regarding	regard	VERB
fnp-2615	229	8	the	the	DET
fnp-2615	229	9	biology	biology	NOUN
fnp-2615	229	10	of	of	ADP
fnp-2615	229	11	pericytes	pericyte	NOUN
fnp-2615	229	12	as	as	ADV
fnp-2615	229	13	well	well	ADV
fnp-2615	229	14	as	as	ADP
fnp-2615	229	15	their	their	PRON
fnp-2615	229	16	role	role	NOUN
fnp-2615	229	17	in	in	ADP
fnp-2615	229	18	vascular	vascular	ADJ
fnp-2615	229	19	function	function	NOUN
fnp-2615	229	20	.	.	PUNCT
fnp-2615	230	1	using	use	VERB
fnp-2615	230	2	pdgfrb	pdgfrb	NOUN
fnp-2615	230	3	-	-	PUNCT
fnp-2615	230	4	creert2	creert2	NOUN
fnp-2615	230	5	mice	mouse	NOUN
fnp-2615	230	6	with	with	ADP
fnp-2615	230	7	cre	cre	PROPN
fnp-2615	230	8	expression	expression	NOUN
fnp-2615	230	9	induced	induce	VERB
fnp-2615	230	10	in	in	ADP
fnp-2615	230	11	mural	mural	ADJ
fnp-2615	230	12	cells	cell	NOUN
fnp-2615	230	13	by	by	ADP
fnp-2615	230	14	tamoxifen	tamoxifen	PROPN
fnp-2615	230	15	administration	administration	PROPN
fnp-2615	230	16	,	,	PUNCT
fnp-2615	230	17	diéguez	diéguez	NOUN
fnp-2615	230	18	-	-	PUNCT
fnp-2615	230	19	hurtado	hurtado	NOUN
fnp-2615	230	20	et	et	NOUN
fnp-2615	230	21	al	al	PROPN
fnp-2615	230	22	.	.	PROPN
fnp-2615	231	1	(	(	PUNCT
fnp-2615	231	2	2019	2019	NUM
fnp-2615	231	3	)	)	PUNCT
fnp-2615	231	4	deleted	delete	VERB
fnp-2615	231	5	the	the	DET
fnp-2615	231	6	expression	expression	NOUN
fnp-2615	231	7	of	of	ADP
fnp-2615	231	8	the	the	DET
fnp-2615	231	9	rbpj	rbpj	PROPN
fnp-2615	231	10	gene	gene	NOUN
fnp-2615	231	11	encoding	encode	VERB
fnp-2615	231	12	a	a	DET
fnp-2615	231	13	transcriptional	transcriptional	ADJ
fnp-2615	231	14	regulator	regulator	NOUN
fnp-2615	231	15	of	of	ADP
fnp-2615	231	16	the	the	DET
fnp-2615	231	17	notch	notch	NOUN
fnp-2615	231	18	signaling	signal	VERB
fnp-2615	231	19	pathway	pathway	NOUN
fnp-2615	231	20	.	.	PUNCT
fnp-2615	232	1	ablation	ablation	NOUN
fnp-2615	232	2	of	of	ADP
fnp-2615	232	3	rbpj	rbpj	PROPN
fnp-2615	232	4	at	at	ADP
fnp-2615	232	5	early	early	ADJ
fnp-2615	232	6	postnatal	postnatal	ADJ
fnp-2615	232	7	stages	stage	NOUN
fnp-2615	232	8	caused	cause	VERB
fnp-2615	232	9	brain	brain	NOUN
fnp-2615	232	10	hemorrhages	hemorrhage	NOUN
fnp-2615	232	11	,	,	PUNCT
fnp-2615	232	12	avms	avms	NOUN
fnp-2615	232	13	at	at	ADP
fnp-2615	232	14	the	the	DET
fnp-2615	232	15	pial	pial	ADJ
fnp-2615	232	16	surface	surface	NOUN
fnp-2615	232	17	,	,	PUNCT
fnp-2615	232	18	endothelial	endothelial	ADJ
fnp-2615	232	19	cell	cell	NOUN
fnp-2615	232	20	hyperplasia	hyperplasia	NOUN
fnp-2615	232	21	and	and	CCONJ
fnp-2615	232	22	apoptosis	apoptosis	NOUN
fnp-2615	232	23	,	,	PUNCT
fnp-2615	232	24	enlargement	enlargement	NOUN
fnp-2615	232	25	of	of	ADP
fnp-2615	232	26	the	the	DET
fnp-2615	232	27	subendothelial	subendothelial	ADJ
fnp-2615	232	28	basement	basement	NOUN
fnp-2615	232	29	membrane	membrane	NOUN
fnp-2615	232	30	,	,	PUNCT
fnp-2615	232	31	and	and	CCONJ
fnp-2615	232	32	reduced	reduce	VERB
fnp-2615	232	33	blood	blood	NOUN
fnp-2615	232	34	flow	flow	NOUN
fnp-2615	232	35	.	.	PUNCT
fnp-2615	233	1	these	these	DET
fnp-2615	233	2	changes	change	NOUN
fnp-2615	233	3	were	be	AUX
fnp-2615	233	4	accompanied	accompany	VERB
fnp-2615	233	5	by	by	ADP
fnp-2615	233	6	astroglial	astroglial	ADJ
fnp-2615	233	7	and	and	CCONJ
fnp-2615	233	8	microglia	microglia	ADJ
fnp-2615	233	9	reactions	reaction	NOUN
fnp-2615	233	10	,	,	PUNCT
fnp-2615	233	11	inflammation	inflammation	NOUN
fnp-2615	233	12	,	,	PUNCT
fnp-2615	233	13	edema	edema	NOUN
fnp-2615	233	14	,	,	PUNCT
fnp-2615	233	15	and	and	CCONJ
fnp-2615	233	16	some	some	DET
fnp-2615	233	17	neuronal	neuronal	ADJ
fnp-2615	233	18	loss	loss	NOUN
fnp-2615	233	19	around	around	ADP
fnp-2615	233	20	severely	severely	ADV
fnp-2615	233	21	affected	affect	VERB
fnp-2615	233	22	blood	blood	NOUN
fnp-2615	233	23	vessels	vessel	NOUN
fnp-2615	233	24	.	.	PUNCT
fnp-2615	234	1	rbpj	rbpj	PROPN
fnp-2615	234	2	deletion	deletion	NOUN
fnp-2615	234	3	upregulated	upregulate	VERB
fnp-2615	234	4	genes	gene	NOUN
fnp-2615	234	5	of	of	ADP
fnp-2615	234	6	the	the	DET
fnp-2615	234	7	tgfß	tgfß	NOUN
fnp-2615	234	8	pathway	pathway	NOUN
fnp-2615	234	9	.	.	PUNCT
fnp-2615	235	1	the	the	DET
fnp-2615	235	2	study	study	NOUN
fnp-2615	235	3	provides	provide	VERB
fnp-2615	235	4	evidence	evidence	NOUN
fnp-2615	235	5	showing	show	VERB
fnp-2615	235	6	that	that	SCONJ
fnp-2615	235	7	mice	mouse	NOUN
fnp-2615	235	8	with	with	ADP
fnp-2615	235	9	rbpj	rbpj	NOUN
fnp-2615	235	10	gene	gene	NOUN
fnp-2615	235	11	deficiency	deficiency	NOUN
fnp-2615	235	12	in	in	ADP
fnp-2615	235	13	mural	mural	ADJ
fnp-2615	235	14	cells	cell	NOUN
fnp-2615	235	15	developed	develop	VERB
fnp-2615	235	16	signs	sign	NOUN
fnp-2615	235	17	of	of	ADP
fnp-2615	235	18	ccms	ccms	NOUN
fnp-2615	235	19	.	.	PUNCT
fnp-2615	236	1	interestingly	interestingly	ADV
fnp-2615	236	2	,	,	PUNCT
fnp-2615	236	3	when	when	SCONJ
fnp-2615	236	4	rbpj	rbpj	PROPN
fnp-2615	236	5	was	be	AUX
fnp-2615	236	6	deleted	delete	VERB
fnp-2615	236	7	in	in	ADP
fnp-2615	236	8	mural	mural	ADJ
fnp-2615	236	9	cells	cell	NOUN
fnp-2615	236	10	of	of	ADP
fnp-2615	236	11	adult	adult	NOUN
fnp-2615	236	12	mice	mouse	NOUN
fnp-2615	236	13	,	,	PUNCT
fnp-2615	236	14	the	the	DET
fnp-2615	236	15	above	above	ADJ
fnp-2615	236	16	phenotype	phenotype	NOUN
fnp-2615	236	17	was	be	AUX
fnp-2615	236	18	no	no	ADV
fnp-2615	236	19	longer	long	ADV
fnp-2615	236	20	observed	observe	VERB
fnp-2615	236	21	.	.	PUNCT
fnp-2615	237	1	however	however	ADV
fnp-2615	237	2	,	,	PUNCT
fnp-2615	237	3	induction	induction	NOUN
fnp-2615	237	4	of	of	ADP
fnp-2615	237	5	permanent	permanent	ADJ
fnp-2615	237	6	brain	brain	NOUN
fnp-2615	237	7	ischemia	ischemia	NOUN
fnp-2615	237	8	in	in	ADP
fnp-2615	237	9	these	these	DET
fnp-2615	237	10	mice	mouse	NOUN
fnp-2615	237	11	caused	cause	VERB
fnp-2615	237	12	increased	increase	VERB
fnp-2615	237	13	edema	edema	NOUN
fnp-2615	237	14	,	,	PUNCT
fnp-2615	237	15	larger	large	ADJ
fnp-2615	237	16	brain	brain	NOUN
fnp-2615	237	17	lesion	lesion	NOUN
fnp-2615	237	18	volumes	volume	NOUN
fnp-2615	237	19	,	,	PUNCT
fnp-2615	237	20	and	and	CCONJ
fnp-2615	237	21	exacerbated	exacerbate	VERB
fnp-2615	237	22	inflammation	inflammation	NOUN
fnp-2615	237	23	and	and	CCONJ
fnp-2615	237	24	vascular	vascular	ADJ
fnp-2615	237	25	abnormalities	abnormality	NOUN
fnp-2615	237	26	.	.	PUNCT
fnp-2615	238	1	beyond	beyond	ADP
fnp-2615	238	2	the	the	DET
fnp-2615	238	3	critical	critical	ADJ
fnp-2615	238	4	role	role	NOUN
fnp-2615	238	5	of	of	ADP
fnp-2615	238	6	pericytes	pericyte	NOUN
fnp-2615	238	7	in	in	ADP
fnp-2615	238	8	brain	brain	NOUN
fnp-2615	238	9	vascular	vascular	ADJ
fnp-2615	238	10	function	function	NOUN
fnp-2615	238	11	,	,	PUNCT
fnp-2615	238	12	nikolakopoulou	nikolakopoulou	NOUN
fnp-2615	238	13	et	et	PROPN
fnp-2615	238	14	al	al	PROPN
fnp-2615	238	15	.	.	PROPN
fnp-2615	239	1	(	(	PUNCT
fnp-2615	239	2	2019	2019	NUM
fnp-2615	239	3	)	)	PUNCT
fnp-2615	239	4	elucidated	elucidate	VERB
fnp-2615	239	5	the	the	DET
fnp-2615	239	6	role	role	NOUN
fnp-2615	239	7	of	of	ADP
fnp-2615	239	8	pericytes	pericyte	NOUN
fnp-2615	239	9	in	in	ADP
fnp-2615	239	10	neuronal	neuronal	ADJ
fnp-2615	239	11	survival	survival	NOUN
fnp-2615	239	12	under	under	ADP
fnp-2615	239	13	conditions	condition	NOUN
fnp-2615	239	14	of	of	ADP
fnp-2615	239	15	vascular	vascular	ADJ
fnp-2615	239	16	dysfunction	dysfunction	NOUN
fnp-2615	239	17	.	.	PUNCT
fnp-2615	240	1	a	a	DET
fnp-2615	240	2	mouse	mouse	NOUN
fnp-2615	240	3	pericyte	pericyte	NOUN
fnp-2615	240	4	inducible	inducible	ADJ
fnp-2615	240	5	cre	cre	PROPN
fnp-2615	240	6	-	-	PUNCT
fnp-2615	240	7	line	line	NOUN
fnp-2615	240	8	was	be	AUX
fnp-2615	240	9	generated	generate	VERB
fnp-2615	240	10	using	use	VERB
fnp-2615	240	11	a	a	DET
fnp-2615	240	12	double	double	ADJ
fnp-2615	240	13	gene	gene	NOUN
fnp-2615	240	14	promoter	promoter	NOUN
fnp-2615	240	15	strategy	strategy	NOUN
fnp-2615	240	16	including	include	VERB
fnp-2615	240	17	both	both	CCONJ
fnp-2615	240	18	pdgfrb	pdgfrb	NOUN
fnp-2615	240	19	and	and	CCONJ
fnp-2615	240	20	cspg4	cspg4	NOUN
fnp-2615	240	21	promoters	promoter	NOUN
fnp-2615	240	22	to	to	PART
fnp-2615	240	23	increase	increase	VERB
fnp-2615	240	24	the	the	DET
fnp-2615	240	25	specificity	specificity	NOUN
fnp-2615	240	26	of	of	ADP
fnp-2615	240	27	cre	cre	PROPN
fnp-2615	240	28	expression	expression	NOUN
fnp-2615	240	29	in	in	ADP
fnp-2615	240	30	pericytes	pericyte	NOUN
fnp-2615	240	31	over	over	ADP
fnp-2615	240	32	other	other	ADJ
fnp-2615	240	33	cells	cell	NOUN
fnp-2615	240	34	.	.	PUNCT
fnp-2615	241	1	this	this	DET
fnp-2615	241	2	line	line	NOUN
fnp-2615	241	3	was	be	AUX
fnp-2615	241	4	crossed	cross	VERB
fnp-2615	241	5	with	with	ADP
fnp-2615	241	6	mice	mouse	NOUN
fnp-2615	241	7	expressing	express	VERB
fnp-2615	241	8	inducible	inducible	ADJ
fnp-2615	241	9	human	human	ADJ
fnp-2615	241	10	diphtheria	diphtheria	NOUN
fnp-2615	241	11	toxin	toxin	NOUN
fnp-2615	241	12	receptor	receptor	NOUN
fnp-2615	241	13	under	under	ADP
fnp-2615	241	14	control	control	NOUN
fnp-2615	241	15	of	of	ADP
fnp-2615	241	16	an	an	DET
fnp-2615	241	17	upstream	upstream	ADJ
fnp-2615	241	18	loxp	loxp	NOUN
fnp-2615	241	19	-	-	PUNCT
fnp-2615	241	20	flanked	flank	VERB
fnp-2615	241	21	stop	stop	NOUN
fnp-2615	241	22	sequence	sequence	NOUN
fnp-2615	241	23	.	.	PUNCT
fnp-2615	242	1	injection	injection	NOUN
fnp-2615	242	2	of	of	ADP
fnp-2615	242	3	tamoxifen	tamoxifen	NOUN
fnp-2615	242	4	induced	induce	VERB
fnp-2615	242	5	dtr	dtr	NOUN
fnp-2615	242	6	expression	expression	NOUN
fnp-2615	242	7	in	in	ADP
fnp-2615	242	8	pericytes	pericyte	NOUN
fnp-2615	242	9	which	which	PRON
fnp-2615	242	10	then	then	ADV
fnp-2615	242	11	became	become	VERB
fnp-2615	242	12	susceptible	susceptible	ADJ
fnp-2615	242	13	to	to	ADP
fnp-2615	242	14	diphtheria	diphtheria	NOUN
fnp-2615	242	15	toxin	toxin	NOUN
fnp-2615	242	16	.	.	PUNCT
fnp-2615	243	1	ablation	ablation	NOUN
fnp-2615	243	2	of	of	ADP
fnp-2615	243	3	pericytes	pericyte	NOUN
fnp-2615	243	4	in	in	ADP
fnp-2615	243	5	adult	adult	NOUN
fnp-2615	243	6	mice	mouse	NOUN
fnp-2615	243	7	reduced	reduce	VERB
fnp-2615	243	8	tight	tight	ADJ
fnp-2615	243	9	junction	junction	NOUN
fnp-2615	243	10	proteins	protein	NOUN
fnp-2615	243	11	zonula	zonula	NOUN
fnp-2615	243	12	occludens	occluden	NOUN
fnp-2615	243	13	and	and	CCONJ
fnp-2615	243	14	occludin	occludin	NOUN
fnp-2615	243	15	,	,	PUNCT
fnp-2615	243	16	reduced	reduce	VERB
fnp-2615	243	17	adherens	adheren	NOUN
fnp-2615	243	18	junction	junction	PROPN
fnp-2615	243	19	ve	ve	NOUN
fnp-2615	243	20	-	-	NOUN
fnp-2615	243	21	cadherin	cadherin	NOUN
fnp-2615	243	22	on	on	ADP
fnp-2615	243	23	cortical	cortical	ADJ
fnp-2615	243	24	and	and	CCONJ
fnp-2615	243	25	hippocampal	hippocampal	ADJ
fnp-2615	243	26	capillaries	capillary	NOUN
fnp-2615	243	27	,	,	PUNCT
fnp-2615	243	28	decreased	decrease	VERB
fnp-2615	243	29	cbf	cbf	PROPN
fnp-2615	243	30	,	,	PUNCT
fnp-2615	243	31	and	and	CCONJ
fnp-2615	243	32	increased	increase	VERB
fnp-2615	243	33	bbb	bbb	NOUN
fnp-2615	243	34	breakdown	breakdown	NOUN
fnp-2615	243	35	.	.	PUNCT
fnp-2615	244	1	pericyte	pericyte	NOUN
fnp-2615	244	2	loss	loss	NOUN
fnp-2615	244	3	was	be	AUX
fnp-2615	244	4	followed	follow	VERB
fnp-2615	244	5	by	by	ADP
fnp-2615	244	6	vasogenic	vasogenic	ADJ
fnp-2615	244	7	edema	edema	NOUN
fnp-2615	244	8	,	,	PUNCT
fnp-2615	244	9	confirming	confirm	VERB
fnp-2615	244	10	the	the	DET
fnp-2615	244	11	involvement	involvement	NOUN
fnp-2615	244	12	of	of	ADP
fnp-2615	244	13	pericytes	pericyte	NOUN
fnp-2615	244	14	in	in	ADP
fnp-2615	244	15	maintaining	maintain	VERB
fnp-2615	244	16	adult	adult	NOUN
fnp-2615	244	17	bbb	bbb	PROPN
fnp-2615	244	18	function	function	NOUN
fnp-2615	244	19	.	.	PUNCT
fnp-2615	245	1	furthermore	furthermore	ADV
fnp-2615	245	2	,	,	PUNCT
fnp-2615	245	3	neuron	neuron	VERB
fnp-2615	245	4	loss	loss	NOUN
fnp-2615	245	5	in	in	ADP
fnp-2615	245	6	the	the	DET
fnp-2615	245	7	cortex	cortex	NOUN
fnp-2615	245	8	and	and	CCONJ
fnp-2615	245	9	hippocampus	hippocampus	NOUN
fnp-2615	245	10	as	as	ADV
fnp-2615	245	11	well	well	ADV
fnp-2615	245	12	as	as	ADP
fnp-2615	245	13	behavioral	behavioral	ADJ
fnp-2615	245	14	deficits	deficit	NOUN
fnp-2615	245	15	were	be	AUX
fnp-2615	245	16	detected	detect	VERB
fnp-2615	245	17	several	several	ADJ
fnp-2615	245	18	days	day	NOUN
fnp-2615	245	19	after	after	ADP
fnp-2615	245	20	pericyte	pericyte	NOUN
fnp-2615	245	21	ablation	ablation	NOUN
fnp-2615	245	22	.	.	PUNCT
fnp-2615	246	1	a	a	DET
fnp-2615	246	2	brain	brain	NOUN
fnp-2615	246	3	-	-	PUNCT
fnp-2615	246	4	specific	specific	ADJ
fnp-2615	246	5	pericyte	pericyte	NOUN
fnp-2615	246	6	-	-	PUNCT
fnp-2615	246	7	secreted	secrete	VERB
fnp-2615	246	8	growth	growth	NOUN
fnp-2615	246	9	factor	factor	NOUN
fnp-2615	246	10	termed	term	VERB
fnp-2615	246	11	pleiotropin	pleiotropin	NOUN
fnp-2615	246	12	was	be	AUX
fnp-2615	246	13	hypothesized	hypothesize	VERB
fnp-2615	246	14	to	to	PART
fnp-2615	246	15	prevent	prevent	VERB
fnp-2615	246	16	neuronal	neuronal	ADJ
fnp-2615	246	17	loss	loss	NOUN
fnp-2615	246	18	.	.	PUNCT
fnp-2615	247	1	in	in	ADP
fnp-2615	247	2	vitro	vitro	X
fnp-2615	247	3	,	,	PUNCT
fnp-2615	247	4	pleiotropin	pleiotropin	NOUN
fnp-2615	247	5	was	be	AUX
fnp-2615	247	6	able	able	ADJ
fnp-2615	247	7	to	to	PART
fnp-2615	247	8	protect	protect	VERB
fnp-2615	247	9	neurons	neuron	NOUN
fnp-2615	247	10	under	under	ADP
fnp-2615	247	11	hypoxic	hypoxic	ADJ
fnp-2615	247	12	conditions	condition	NOUN
fnp-2615	247	13	.	.	PUNCT
fnp-2615	248	1	in	in	ADP
fnp-2615	248	2	vivo	vivo	NOUN
fnp-2615	248	3	,	,	PUNCT
fnp-2615	248	4	silencing	silence	VERB
fnp-2615	248	5	pleiotropin	pleiotropin	NOUN
fnp-2615	248	6	expression	expression	NOUN
fnp-2615	248	7	was	be	AUX
fnp-2615	248	8	not	not	PART
fnp-2615	248	9	sufficient	sufficient	ADJ
fnp-2615	248	10	to	to	PART
fnp-2615	248	11	cause	cause	VERB
fnp-2615	248	12	neuronal	neuronal	ADJ
fnp-2615	248	13	loss	loss	NOUN
fnp-2615	248	14	.	.	PUNCT
fnp-2615	249	1	however	however	ADV
fnp-2615	249	2	,	,	PUNCT
fnp-2615	249	3	ischemia	ischemia	NOUN
fnp-2615	249	4	or	or	CCONJ
fnp-2615	249	5	excitotoxic	excitotoxic	ADJ
fnp-2615	249	6	lesions	lesion	NOUN
fnp-2615	249	7	in	in	ADP
fnp-2615	249	8	mice	mouse	NOUN
fnp-2615	249	9	with	with	ADP
fnp-2615	249	10	silenced	silence	VERB
fnp-2615	249	11	pleiotropin	pleiotropin	NOUN
fnp-2615	249	12	expression	expression	NOUN
fnp-2615	249	13	caused	cause	VERB
fnp-2615	249	14	larger	large	ADJ
fnp-2615	249	15	infarctions	infarction	NOUN
fnp-2615	249	16	and	and	CCONJ
fnp-2615	249	17	more	more	ADJ
fnp-2615	249	18	neuronal	neuronal	ADJ
fnp-2615	249	19	degeneration	degeneration	NOUN
fnp-2615	249	20	.	.	PUNCT
fnp-2615	250	1	the	the	DET
fnp-2615	250	2	study	study	NOUN
fnp-2615	250	3	concluded	conclude	VERB
fnp-2615	250	4	that	that	SCONJ
fnp-2615	250	5	pericyte	pericyte	NOUN
fnp-2615	250	6	-	-	PUNCT
fnp-2615	250	7	dependent	dependent	ADJ
fnp-2615	250	8	pleiotropin	pleiotropin	NOUN
fnp-2615	250	9	-	-	PUNCT
fnp-2615	250	10	mediated	mediate	VERB
fnp-2615	250	11	neurotrophic	neurotrophic	ADJ
fnp-2615	250	12	support	support	NOUN
fnp-2615	250	13	promotes	promote	VERB
fnp-2615	250	14	neuronal	neuronal	ADJ
fnp-2615	250	15	survival	survival	NOUN
fnp-2615	250	16	under	under	ADP
fnp-2615	250	17	circulatory	circulatory	ADJ
fnp-2615	250	18	stress	stress	NOUN
fnp-2615	250	19	.	.	PUNCT
fnp-2615	251	1	the	the	DET
fnp-2615	251	2	expedient	expedient	ADJ
fnp-2615	251	3	neuronal	neuronal	ADJ
fnp-2615	251	4	loss	loss	NOUN
fnp-2615	251	5	found	find	VERB
fnp-2615	251	6	in	in	ADP
fnp-2615	251	7	this	this	DET
fnp-2615	251	8	model	model	NOUN
fnp-2615	251	9	of	of	ADP
fnp-2615	251	10	pericyte	pericyte	NOUN
fnp-2615	251	11	ablation	ablation	NOUN
fnp-2615	251	12	is	be	AUX
fnp-2615	251	13	intriguing	intriguing	ADJ
fnp-2615	251	14	because	because	SCONJ
fnp-2615	251	15	it	it	PRON
fnp-2615	251	16	was	be	AUX
fnp-2615	251	17	not	not	PART
fnp-2615	251	18	found	find	VERB
fnp-2615	251	19	in	in	ADP
fnp-2615	251	20	previous	previous	ADJ
fnp-2615	251	21	pericyte	pericyte	NOUN
fnp-2615	251	22	-	-	PUNCT
fnp-2615	251	23	deficient	deficient	ADJ
fnp-2615	251	24	models	model	NOUN
fnp-2615	251	25	.	.	PUNCT
fnp-2615	252	1	the	the	DET
fnp-2615	252	2	findings	finding	NOUN
fnp-2615	252	3	could	could	AUX
fnp-2615	252	4	be	be	AUX
fnp-2615	252	5	relevant	relevant	ADJ
fnp-2615	252	6	to	to	ADP
fnp-2615	252	7	other	other	ADJ
fnp-2615	252	8	neurodegenerative	neurodegenerative	ADJ
fnp-2615	252	9	conditions	condition	NOUN
fnp-2615	252	10	if	if	SCONJ
fnp-2615	252	11	the	the	DET
fnp-2615	252	12	dependence	dependence	NOUN
fnp-2615	252	13	of	of	ADP
fnp-2615	252	14	neuronal	neuronal	ADJ
fnp-2615	252	15	survival	survival	NOUN
fnp-2615	252	16	on	on	ADP
fnp-2615	252	17	neurotrophic	neurotrophic	ADJ
fnp-2615	252	18	factors	factor	NOUN
fnp-2615	252	19	provided	provide	VERB
fnp-2615	252	20	by	by	ADP
fnp-2615	252	21	pericytes	pericyte	NOUN
fnp-2615	252	22	under	under	ADP
fnp-2615	252	23	vascular	vascular	ADJ
fnp-2615	252	24	stress	stress	NOUN
fnp-2615	252	25	is	be	AUX
fnp-2615	252	26	confirmed	confirm	VERB
fnp-2615	252	27	.	.	PUNCT
fnp-2615	253	1	10	10	NUM
fnp-2615	253	2	.	.	PUNCT
fnp-2615	253	3	molecules	molecule	NOUN
fnp-2615	253	4	derived	derive	VERB
fnp-2615	253	5	from	from	ADP
fnp-2615	253	6	the	the	DET
fnp-2615	253	7	vascular	vascular	ADJ
fnp-2615	253	8	endothelium	endothelium	NOUN
fnp-2615	253	9	impact	impact	NOUN
fnp-2615	253	10	neuronal	neuronal	ADJ
fnp-2615	253	11	function	function	NOUN
fnp-2615	253	12	in	in	ADP
fnp-2615	253	13	addition	addition	NOUN
fnp-2615	253	14	to	to	ADP
fnp-2615	253	15	pericytes	pericyte	NOUN
fnp-2615	253	16	,	,	PUNCT
fnp-2615	253	17	endothelial	endothelial	ADJ
fnp-2615	253	18	cells	cell	NOUN
fnp-2615	253	19	seem	seem	VERB
fnp-2615	253	20	to	to	PART
fnp-2615	253	21	signal	signal	VERB
fnp-2615	253	22	to	to	ADP
fnp-2615	253	23	neurons	neuron	NOUN
fnp-2615	253	24	.	.	PUNCT
fnp-2615	254	1	tan	tan	PROPN
fnp-2615	254	2	et	et	PROPN
fnp-2615	254	3	al	al	PROPN
fnp-2615	254	4	.	.	PROPN
fnp-2615	255	1	(	(	PUNCT
fnp-2615	255	2	2019	2019	NUM
fnp-2615	255	3	)	)	PUNCT
fnp-2615	255	4	showed	show	VERB
fnp-2615	255	5	that	that	SCONJ
fnp-2615	255	6	the	the	DET
fnp-2615	255	7	endothelium	endothelium	NOUN
fnp-2615	255	8	secretes	secrete	NOUN
fnp-2615	255	9	semaphorin	semaphorin	NOUN
fnp-2615	255	10	3	3	NUM
fnp-2615	255	11	g	g	NOUN
fnp-2615	255	12	(	(	PUNCT
fnp-2615	255	13	sema3	sema3	NOUN
fnp-2615	255	14	g	g	NOUN
fnp-2615	255	15	)	)	PUNCT
fnp-2615	255	16	which	which	PRON
fnp-2615	255	17	regulates	regulate	VERB
fnp-2615	255	18	synaptic	synaptic	ADJ
fnp-2615	255	19	structure	structure	NOUN
fnp-2615	255	20	and	and	CCONJ
fnp-2615	255	21	plasticity	plasticity	NOUN
fnp-2615	255	22	in	in	ADP
fnp-2615	255	23	hippocampal	hippocampal	ADJ
fnp-2615	255	24	neurons	neuron	NOUN
fnp-2615	255	25	through	through	ADP
fnp-2615	255	26	actions	action	NOUN
fnp-2615	255	27	on	on	ADP
fnp-2615	255	28	the	the	DET
fnp-2615	255	29	neuronal	neuronal	ADJ
fnp-2615	255	30	neuropilin-2	neuropilin-2	NUM
fnp-2615	255	31	/	/	SYM
fnp-2615	255	32	plexina4	plexina4	NOUN
fnp-2615	255	33	holoreceptor	holoreceptor	NOUN
fnp-2615	255	34	.	.	PUNCT
fnp-2615	256	1	this	this	DET
fnp-2615	256	2	study	study	NOUN
fnp-2615	256	3	suggests	suggest	VERB
fnp-2615	256	4	a	a	DET
fnp-2615	256	5	direct	direct	ADJ
fnp-2615	256	6	link	link	NOUN
fnp-2615	256	7	between	between	ADP
fnp-2615	256	8	endothelial	endothelial	NOUN
fnp-2615	256	9	-	-	PUNCT
fnp-2615	256	10	derived	derive	VERB
fnp-2615	256	11	factors	factor	NOUN
fnp-2615	256	12	and	and	CCONJ
fnp-2615	256	13	neuronal	neuronal	ADJ
fnp-2615	256	14	function	function	NOUN
fnp-2615	256	15	beyond	beyond	ADP
fnp-2615	256	16	the	the	DET
fnp-2615	256	17	supply	supply	NOUN
fnp-2615	256	18	of	of	ADP
fnp-2615	256	19	oxygen	oxygen	NOUN
fnp-2615	256	20	and	and	CCONJ
fnp-2615	256	21	nutrients	nutrient	NOUN
fnp-2615	256	22	through	through	ADP
fnp-2615	256	23	blood	blood	NOUN
fnp-2615	256	24	flow	flow	NOUN
fnp-2615	256	25	and	and	CCONJ
fnp-2615	256	26	proposes	propose	VERB
fnp-2615	256	27	a	a	DET
fnp-2615	256	28	molecular	molecular	ADJ
fnp-2615	256	29	mechanism	mechanism	NOUN
fnp-2615	256	30	by	by	ADP
fnp-2615	256	31	which	which	PRON
fnp-2615	256	32	endothelial	endothelial	ADJ
fnp-2615	256	33	dysfunction	dysfunction	NOUN
fnp-2615	256	34	can	can	AUX
fnp-2615	256	35	alter	alter	VERB
fnp-2615	256	36	neuronal	neuronal	ADJ
fnp-2615	256	37	circuits	circuit	NOUN
fnp-2615	256	38	and	and	CCONJ
fnp-2615	256	39	cognition	cognition	NOUN
fnp-2615	256	40	.	.	PUNCT
fnp-2615	257	1	the	the	DET
fnp-2615	257	2	study	study	NOUN
fnp-2615	257	3	shows	show	VERB
fnp-2615	257	4	that	that	SCONJ
fnp-2615	257	5	sema3	sema3	NOUN
fnp-2615	257	6	g	g	PROPN
fnp-2615	257	7	increases	increase	VERB
fnp-2615	257	8	excitatory	excitatory	ADJ
fnp-2615	257	9	synapse	synapse	NOUN
fnp-2615	257	10	density	density	NOUN
fnp-2615	257	11	via	via	ADP
fnp-2615	257	12	neuropilin-2	neuropilin-2	NUM
fnp-2615	257	13	/	/	SYM
fnp-2615	257	14	plexina4	plexina4	NOUN
fnp-2615	257	15	signaling	signal	VERB
fnp-2615	257	16	and	and	CCONJ
fnp-2615	257	17	activation	activation	NOUN
fnp-2615	257	18	of	of	ADP
fnp-2615	257	19	rac1	rac1	PROPN
fnp-2615	257	20	.	.	PUNCT
fnp-2615	258	1	to	to	PART
fnp-2615	258	2	determine	determine	VERB
fnp-2615	258	3	whether	whether	SCONJ
fnp-2615	258	4	sema3	sema3	NOUN
fnp-2615	258	5	g	g	PROPN
fnp-2615	258	6	was	be	AUX
fnp-2615	258	7	derived	derive	VERB
fnp-2615	258	8	from	from	ADP
fnp-2615	258	9	endothelial	endothelial	ADJ
fnp-2615	258	10	cells	cell	NOUN
fnp-2615	258	11	,	,	PUNCT
fnp-2615	258	12	mice	mouse	NOUN
fnp-2615	258	13	bearing	bear	VERB
fnp-2615	258	14	a	a	DET
fnp-2615	258	15	sema3	sema3	NOUN
fnp-2615	258	16	g	g	PROPN
fnp-2615	258	17	deletion	deletion	NOUN
fnp-2615	258	18	selectively	selectively	ADV
fnp-2615	258	19	in	in	ADP
fnp-2615	258	20	endothelial	endothelial	ADJ
fnp-2615	258	21	cells	cell	NOUN
fnp-2615	258	22	were	be	AUX
fnp-2615	258	23	obtained	obtain	VERB
fnp-2615	258	24	by	by	ADP
fnp-2615	258	25	crossing	cross	VERB
fnp-2615	258	26	cdh5	cdh5	PROPN
fnp-2615	258	27	-	-	PUNCT
fnp-2615	258	28	cre	cre	PROPN
fnp-2615	258	29	mice	mouse	NOUN
fnp-2615	258	30	with	with	ADP
fnp-2615	258	31	floxed	floxed	ADJ
fnp-2615	258	32	sema3	sema3	NOUN
fnp-2615	258	33	g	g	PROPN
fnp-2615	258	34	mice	mouse	NOUN
fnp-2615	258	35	.	.	PUNCT
fnp-2615	259	1	these	these	DET
fnp-2615	259	2	mice	mouse	NOUN
fnp-2615	259	3	showed	show	VERB
fnp-2615	259	4	less	less	ADV
fnp-2615	259	5	dendritic	dendritic	ADJ
fnp-2615	259	6	spine	spine	ADJ
fnp-2615	259	7	density	density	NOUN
fnp-2615	259	8	in	in	ADP
fnp-2615	259	9	the	the	DET
fnp-2615	259	10	ca1	ca1	NOUN
fnp-2615	259	11	and	and	CCONJ
fnp-2615	259	12	impaired	impaired	ADJ
fnp-2615	259	13	memory	memory	NOUN
fnp-2615	259	14	.	.	PUNCT
fnp-2615	260	1	nonetheless	nonetheless	ADV
fnp-2615	260	2	,	,	PUNCT
fnp-2615	260	3	sema3	sema3	NOUN
fnp-2615	260	4	g	g	PROPN
fnp-2615	260	5	deletion	deletion	NOUN
fnp-2615	260	6	with	with	ADP
fnp-2615	260	7	this	this	DET
fnp-2615	260	8	strategy	strategy	NOUN
fnp-2615	260	9	would	would	AUX
fnp-2615	260	10	cause	cause	VERB
fnp-2615	260	11	sema3	sema3	NOUN
fnp-2615	260	12	g	g	NOUN
fnp-2615	260	13	deficiency	deficiency	NOUN
fnp-2615	260	14	during	during	ADP
fnp-2615	260	15	developmental	developmental	ADJ
fnp-2615	260	16	stages	stage	NOUN
fnp-2615	260	17	which	which	PRON
fnp-2615	260	18	may	may	AUX
fnp-2615	260	19	cause	cause	VERB
fnp-2615	260	20	indirect	indirect	ADJ
fnp-2615	260	21	alterations	alteration	NOUN
fnp-2615	260	22	and	and	CCONJ
fnp-2615	260	23	compensatory	compensatory	ADJ
fnp-2615	260	24	changes	change	NOUN
fnp-2615	260	25	.	.	PUNCT
fnp-2615	261	1	generation	generation	NOUN
fnp-2615	261	2	of	of	ADP
fnp-2615	261	3	tamoxifen	tamoxifen	NOUN
fnp-2615	261	4	inducible	inducible	ADJ
fnp-2615	261	5	cdh5	cdh5	NOUN
fnp-2615	261	6	-	-	PUNCT
fnp-2615	261	7	creert2	creert2	PROPN
fnp-2615	261	8	/	/	SYM
fnp-2615	261	9	sema3gfl	sema3gfl	NOUN
fnp-2615	261	10	/	/	SYM
fnp-2615	261	11	fl	fl	NUM
fnp-2615	261	12	mice	mouse	NOUN
fnp-2615	261	13	allowed	allow	VERB
fnp-2615	261	14	deleting	delete	VERB
fnp-2615	261	15	sema3	sema3	NOUN
fnp-2615	261	16	g	g	NOUN
fnp-2615	261	17	in	in	ADP
fnp-2615	261	18	the	the	DET
fnp-2615	261	19	endothelium	endothelium	NOUN
fnp-2615	261	20	of	of	ADP
fnp-2615	261	21	adult	adult	NOUN
fnp-2615	261	22	mice	mouse	NOUN
fnp-2615	261	23	.	.	PUNCT
fnp-2615	262	1	this	this	DET
fnp-2615	262	2	inducible	inducible	ADJ
fnp-2615	262	3	deletion	deletion	NOUN
fnp-2615	262	4	significantly	significantly	ADV
fnp-2615	262	5	impaired	impair	VERB
fnp-2615	262	6	hippocampal	hippocampal	ADJ
fnp-2615	262	7	long	long	ADJ
fnp-2615	262	8	-	-	PUNCT
fnp-2615	262	9	term	term	NOUN
fnp-2615	262	10	potentiation	potentiation	NOUN
fnp-2615	262	11	frequency	frequency	NOUN
fnp-2615	262	12	and	and	CCONJ
fnp-2615	262	13	altered	alter	VERB
fnp-2615	262	14	miniature	miniature	ADJ
fnp-2615	262	15	excitatory	excitatory	ADJ
fnp-2615	262	16	post	post	ADJ
fnp-2615	262	17	-	-	ADJ
fnp-2615	262	18	synaptic	synaptic	ADJ
fnp-2615	262	19	currents	current	NOUN
fnp-2615	262	20	in	in	ADP
fnp-2615	262	21	ca1	ca1	NOUN
fnp-2615	262	22	pyramidal	pyramidal	ADJ
fnp-2615	262	23	neurons	neuron	NOUN
fnp-2615	262	24	.	.	PUNCT
fnp-2615	263	1	furthermore	furthermore	ADV
fnp-2615	263	2	,	,	PUNCT
fnp-2615	263	3	sema3	sema3	NOUN
fnp-2615	263	4	g	g	NOUN
fnp-2615	263	5	overexpression	overexpression	NOUN
fnp-2615	263	6	improved	improve	VERB
fnp-2615	263	7	spine	spine	ADJ
fnp-2615	263	8	density	density	NOUN
fnp-2615	263	9	loss	loss	NOUN
fnp-2615	263	10	and	and	CCONJ
fnp-2615	263	11	cognitive	cognitive	ADJ
fnp-2615	263	12	defects	defect	NOUN
fnp-2615	263	13	in	in	ADP
fnp-2615	263	14	cdh5	cdh5	PROPN
fnp-2615	263	15	-	-	PUNCT
fnp-2615	263	16	creert2	creert2	PROPN
fnp-2615	263	17	/	/	SYM
fnp-2615	263	18	sema3gfl	sema3gfl	NOUN
fnp-2615	263	19	/	/	SYM
fnp-2615	263	20	fl	fl	NUM
fnp-2615	263	21	mice	mouse	NOUN
fnp-2615	263	22	.	.	PUNCT
fnp-2615	264	1	the	the	DET
fnp-2615	264	2	results	result	NOUN
fnp-2615	264	3	suggest	suggest	VERB
fnp-2615	264	4	that	that	SCONJ
fnp-2615	264	5	endothelium	endothelium	NOUN
fnp-2615	264	6	-	-	PUNCT
fnp-2615	264	7	derived	derive	VERB
fnp-2615	264	8	sema3	sema3	NOUN
fnp-2615	264	9	g	g	PROPN
fnp-2615	264	10	is	be	AUX
fnp-2615	264	11	required	require	VERB
fnp-2615	264	12	for	for	ADP
fnp-2615	264	13	normal	normal	ADJ
fnp-2615	264	14	hippocampal	hippocampal	ADJ
fnp-2615	264	15	synaptic	synaptic	ADJ
fnp-2615	264	16	plasticity	plasticity	NOUN
fnp-2615	264	17	in	in	ADP
fnp-2615	264	18	adulthood	adulthood	NOUN
fnp-2615	264	19	.	.	PUNCT
fnp-2615	265	1	this	this	DET
fnp-2615	265	2	study	study	NOUN
fnp-2615	265	3	raises	raise	VERB
fnp-2615	265	4	many	many	ADJ
fnp-2615	265	5	questions	question	NOUN
fnp-2615	265	6	regarding	regard	VERB
fnp-2615	265	7	the	the	DET
fnp-2615	265	8	mode	mode	NOUN
fnp-2615	265	9	of	of	ADP
fnp-2615	265	10	transit	transit	NOUN
fnp-2615	265	11	of	of	ADP
fnp-2615	265	12	sema3	sema3	PROPN
fnp-2615	265	13	g	g	PROPN
fnp-2615	265	14	from	from	ADP
fnp-2615	265	15	the	the	DET
fnp-2615	265	16	vascular	vascular	ADJ
fnp-2615	265	17	endothelium	endothelium	NOUN
fnp-2615	265	18	to	to	ADP
fnp-2615	265	19	the	the	DET
fnp-2615	265	20	neurons	neuron	NOUN
fnp-2615	265	21	through	through	ADP
fnp-2615	265	22	the	the	DET
fnp-2615	265	23	vascular	vascular	ADJ
fnp-2615	265	24	and	and	CCONJ
fnp-2615	265	25	astrocytic	astrocytic	ADJ
fnp-2615	265	26	basal	basal	NOUN
fnp-2615	265	27	laminae	laminae	NOUN
fnp-2615	265	28	and	and	CCONJ
fnp-2615	265	29	astrocytic	astrocytic	ADJ
fnp-2615	265	30	end	end	NOUN
fnp-2615	265	31	-	-	PUNCT
fnp-2615	265	32	feet	foot	NOUN
fnp-2615	265	33	,	,	PUNCT
fnp-2615	265	34	and	and	CCONJ
fnp-2615	265	35	whether	whether	SCONJ
fnp-2615	265	36	the	the	DET
fnp-2615	265	37	source	source	NOUN
fnp-2615	265	38	of	of	ADP
fnp-2615	265	39	sema3	sema3	PROPN
fnp-2615	265	40	g	g	PROPN
fnp-2615	265	41	is	be	AUX
fnp-2615	265	42	the	the	DET
fnp-2615	265	43	capillary	capillary	ADJ
fnp-2615	265	44	endothelium	endothelium	NOUN
fnp-2615	265	45	.	.	PUNCT
fnp-2615	266	1	the	the	DET
fnp-2615	266	2	discovery	discovery	NOUN
fnp-2615	266	3	of	of	ADP
fnp-2615	266	4	molecular	molecular	ADJ
fnp-2615	266	5	interactions	interaction	NOUN
fnp-2615	266	6	between	between	ADP
fnp-2615	266	7	endothelial	endothelial	ADJ
fnp-2615	266	8	cells	cell	NOUN
fnp-2615	266	9	and	and	CCONJ
fnp-2615	266	10	neurons	neuron	NOUN
fnp-2615	266	11	suggest	suggest	VERB
fnp-2615	266	12	that	that	SCONJ
fnp-2615	266	13	endothelial	endothelial	ADJ
fnp-2615	266	14	cells	cell	NOUN
fnp-2615	266	15	influence	influence	VERB
fnp-2615	266	16	neuronal	neuronal	ADJ
fnp-2615	266	17	function	function	NOUN
fnp-2615	266	18	.	.	PUNCT
fnp-2615	267	1	therefore	therefore	ADV
fnp-2615	267	2	,	,	PUNCT
fnp-2615	267	3	alterations	alteration	NOUN
fnp-2615	267	4	in	in	ADP
fnp-2615	267	5	the	the	DET
fnp-2615	267	6	vascular	vascular	ADJ
fnp-2615	267	7	endothelium	endothelium	NOUN
fnp-2615	267	8	might	might	AUX
fnp-2615	267	9	exert	exert	VERB
fnp-2615	267	10	a	a	DET
fnp-2615	267	11	direct	direct	ADJ
fnp-2615	267	12	effect	effect	NOUN
fnp-2615	267	13	on	on	ADP
fnp-2615	267	14	dendritic	dendritic	ADJ
fnp-2615	267	15	spine	spine	ADJ
fnp-2615	267	16	function	function	NOUN
fnp-2615	267	17	and	and	CCONJ
fnp-2615	267	18	contribute	contribute	VERB
fnp-2615	267	19	to	to	ADP
fnp-2615	267	20	cognitive	cognitive	ADJ
fnp-2615	267	21	decline	decline	NOUN
fnp-2615	267	22	and	and	CCONJ
fnp-2615	267	23	memory	memory	NOUN
fnp-2615	267	24	loss	loss	NOUN
fnp-2615	267	25	.	.	PUNCT
fnp-2615	268	1	other	other	ADJ
fnp-2615	268	2	recent	recent	ADJ
fnp-2615	268	3	studies	study	NOUN
fnp-2615	268	4	further	far	ADV
fnp-2615	268	5	support	support	VERB
fnp-2615	268	6	the	the	DET
fnp-2615	268	7	view	view	NOUN
fnp-2615	268	8	that	that	SCONJ
fnp-2615	268	9	molecules	molecule	NOUN
fnp-2615	268	10	generated	generate	VERB
fnp-2615	268	11	by	by	ADP
fnp-2615	268	12	the	the	DET
fnp-2615	268	13	cerebrovascular	cerebrovascular	ADJ
fnp-2615	268	14	endothelium	endothelium	NOUN
fnp-2615	268	15	have	have	AUX
fnp-2615	268	16	a	a	DET
fnp-2615	268	17	direct	direct	ADJ
fnp-2615	268	18	impact	impact	NOUN
fnp-2615	268	19	on	on	ADP
fnp-2615	268	20	neuronal	neuronal	ADJ
fnp-2615	268	21	function	function	NOUN
fnp-2615	268	22	.	.	PUNCT
fnp-2615	269	1	liu	liu	PROPN
fnp-2615	269	2	et	et	PROPN
fnp-2615	269	3	al	al	PROPN
fnp-2615	269	4	.	.	PROPN
fnp-2615	269	5	(	(	PUNCT
fnp-2615	269	6	2020	2020	NUM
fnp-2615	269	7	)	)	PUNCT
fnp-2615	269	8	showed	show	VERB
fnp-2615	269	9	that	that	SCONJ
fnp-2615	269	10	mice	mouse	NOUN
fnp-2615	269	11	with	with	ADP
fnp-2615	269	12	a	a	DET
fnp-2615	269	13	selective	selective	ADJ
fnp-2615	269	14	deletion	deletion	NOUN
fnp-2615	269	15	of	of	ADP
fnp-2615	269	16	cdk5	cdk5	PROPN
fnp-2615	269	17	gene	gene	NOUN
fnp-2615	269	18	show	show	VERB
fnp-2615	269	19	a	a	DET
fnp-2615	269	20	higher	high	ADJ
fnp-2615	269	21	endothelial	endothelial	ADJ
fnp-2615	269	22	chemokine	chemokine	ADJ
fnp-2615	269	23	cxcl1	cxcl1	NOUN
fnp-2615	269	24	expression	expression	NOUN
fnp-2615	269	25	.	.	PUNCT
fnp-2615	270	1	therefore	therefore	ADV
fnp-2615	270	2	,	,	PUNCT
fnp-2615	270	3	dysregulation	dysregulation	NOUN
fnp-2615	270	4	of	of	ADP
fnp-2615	270	5	cdk5	cdk5	PROPN
fnp-2615	270	6	expression	expression	NOUN
fnp-2615	270	7	and/or	and/or	CCONJ
fnp-2615	270	8	function	function	NOUN
fnp-2615	270	9	seems	seem	VERB
fnp-2615	270	10	to	to	PART
fnp-2615	270	11	be	be	AUX
fnp-2615	270	12	critical	critical	ADJ
fnp-2615	270	13	in	in	ADP
fnp-2615	270	14	different	different	ADJ
fnp-2615	270	15	forms	form	NOUN
fnp-2615	270	16	of	of	ADP
fnp-2615	270	17	cerebrovascular	cerebrovascular	ADJ
fnp-2615	270	18	alterations	alteration	NOUN
fnp-2615	270	19	.	.	PUNCT
fnp-2615	271	1	endothelial	endothelial	ADJ
fnp-2615	271	2	cdk5	cdk5	PROPN
fnp-2615	271	3	knockout	knockout	NOUN
fnp-2615	271	4	mice	mouse	NOUN
fnp-2615	271	5	showed	show	VERB
fnp-2615	271	6	astrogliosis	astrogliosis	NOUN
fnp-2615	271	7	in	in	ADP
fnp-2615	271	8	the	the	DET
fnp-2615	271	9	hippocampus	hippocampus	NOUN
fnp-2615	271	10	and	and	CCONJ
fnp-2615	271	11	weakened	weaken	VERB
fnp-2615	271	12	astrocytic	astrocytic	ADJ
fnp-2615	271	13	glutamate	glutamate	NOUN
fnp-2615	271	14	current	current	NOUN
fnp-2615	271	15	mediated	mediate	VERB
fnp-2615	271	16	by	by	ADP
fnp-2615	271	17	the	the	DET
fnp-2615	271	18	astroglial	astroglial	ADJ
fnp-2615	271	19	glutamate	glutamate	NOUN
fnp-2615	271	20	transporter	transporter	NOUN
fnp-2615	271	21	glt1	glt1	NOUN
fnp-2615	271	22	.	.	PUNCT
fnp-2615	272	1	the	the	DET
fnp-2615	272	2	effects	effect	NOUN
fnp-2615	272	3	on	on	ADP
fnp-2615	272	4	astroglia	astroglia	PROPN
fnp-2615	272	5	were	be	AUX
fnp-2615	272	6	mediated	mediate	VERB
fnp-2615	272	7	by	by	ADP
fnp-2615	272	8	endothelial	endothelial	NOUN
fnp-2615	272	9	-	-	PUNCT
fnp-2615	272	10	derived	derive	VERB
fnp-2615	272	11	cxcl1	cxcl1	NOUN
fnp-2615	272	12	acting	act	VERB
fnp-2615	272	13	on	on	ADP
fnp-2615	272	14	the	the	DET
fnp-2615	272	15	astrocytic	astrocytic	ADJ
fnp-2615	272	16	receptor	receptor	NOUN
fnp-2615	272	17	cxcr2	cxcr2	NOUN
fnp-2615	272	18	.	.	PUNCT
fnp-2615	273	1	these	these	DET
fnp-2615	273	2	alterations	alteration	NOUN
fnp-2615	273	3	had	have	VERB
fnp-2615	273	4	consequences	consequence	NOUN
fnp-2615	273	5	for	for	ADP
fnp-2615	273	6	neurons	neuron	NOUN
fnp-2615	273	7	since	since	SCONJ
fnp-2615	273	8	they	they	PRON
fnp-2615	273	9	reduced	reduce	VERB
fnp-2615	273	10	glutamate	glutamate	ADJ
fnp-2615	273	11	uptake	uptake	NOUN
fnp-2615	273	12	and	and	CCONJ
fnp-2615	273	13	increased	increase	VERB
fnp-2615	273	14	the	the	DET
fnp-2615	273	15	excitability	excitability	NOUN
fnp-2615	273	16	of	of	ADP
fnp-2615	273	17	hippocampal	hippocampal	ADJ
fnp-2615	273	18	pyramidal	pyramidal	ADJ
fnp-2615	273	19	neurons	neuron	NOUN
fnp-2615	273	20	causing	cause	VERB
fnp-2615	273	21	seizures	seizure	NOUN
fnp-2615	273	22	in	in	ADP
fnp-2615	273	23	mice	mouse	NOUN
fnp-2615	273	24	with	with	ADP
fnp-2615	273	25	endothelial	endothelial	ADJ
fnp-2615	273	26	-	-	PUNCT
fnp-2615	273	27	deficient	deficient	ADJ
fnp-2615	273	28	cdk5	cdk5	NOUN
fnp-2615	273	29	.	.	PUNCT
fnp-2615	274	1	although	although	SCONJ
fnp-2615	274	2	current	current	ADJ
fnp-2615	274	3	evidence	evidence	NOUN
fnp-2615	274	4	is	be	AUX
fnp-2615	274	5	still	still	ADV
fnp-2615	274	6	scarce	scarce	ADJ
fnp-2615	274	7	and	and	CCONJ
fnp-2615	274	8	based	base	VERB
fnp-2615	274	9	on	on	ADP
fnp-2615	274	10	experimental	experimental	ADJ
fnp-2615	274	11	animal	animal	NOUN
fnp-2615	274	12	studies	study	NOUN
fnp-2615	274	13	,	,	PUNCT
fnp-2615	274	14	the	the	DET
fnp-2615	274	15	possibility	possibility	NOUN
fnp-2615	274	16	that	that	SCONJ
fnp-2615	274	17	vascular	vascular	ADJ
fnp-2615	274	18	endothelial	endothelial	NOUN
fnp-2615	274	19	cells	cell	NOUN
fnp-2615	274	20	generate	generate	VERB
fnp-2615	274	21	molecules	molecule	NOUN
fnp-2615	274	22	that	that	PRON
fnp-2615	274	23	signal	signal	VERB
fnp-2615	274	24	to	to	ADP
fnp-2615	274	25	neurons	neuron	NOUN
fnp-2615	274	26	and	and	CCONJ
fnp-2615	274	27	astrocytes	astrocyte	NOUN
fnp-2615	274	28	and	and	CCONJ
fnp-2615	274	29	govern	govern	VERB
fnp-2615	274	30	neuronal	neuronal	ADJ
fnp-2615	274	31	function	function	NOUN
fnp-2615	274	32	warrants	warrant	NOUN
fnp-2615	274	33	future	future	ADJ
fnp-2615	274	34	studies	study	NOUN
fnp-2615	274	35	.	.	PUNCT
fnp-2615	275	1	conclusion	conclusion	NOUN
fnp-2615	275	2	the	the	DET
fnp-2615	275	3	above	above	ADJ
fnp-2615	275	4	studies	study	NOUN
fnp-2615	275	5	discovered	discover	VERB
fnp-2615	275	6	contributing	contribute	VERB
fnp-2615	275	7	factors	factor	NOUN
fnp-2615	275	8	to	to	ADP
fnp-2615	275	9	neurovascular	neurovascular	ADJ
fnp-2615	275	10	pathology	pathology	NOUN
fnp-2615	275	11	.	.	PUNCT
fnp-2615	276	1	adequate	adequate	ADJ
fnp-2615	276	2	cbf	cbf	PROPN
fnp-2615	276	3	supply	supply	PROPN
fnp-2615	276	4	and	and	CCONJ
fnp-2615	276	5	bbb	bbb	PROPN
fnp-2615	276	6	integrity	integrity	NOUN
fnp-2615	276	7	require	require	VERB
fnp-2615	276	8	homeostasis	homeostasis	NOUN
fnp-2615	276	9	in	in	ADP
fnp-2615	276	10	the	the	DET
fnp-2615	276	11	cellular	cellular	ADJ
fnp-2615	276	12	and	and	CCONJ
fnp-2615	276	13	extracellular	extracellular	ADJ
fnp-2615	276	14	environment	environment	NOUN
fnp-2615	276	15	around	around	ADP
fnp-2615	276	16	blood	blood	NOUN
fnp-2615	276	17	vessels	vessel	NOUN
fnp-2615	276	18	.	.	PUNCT
fnp-2615	277	1	moreo	moreo	PROPN
fnp-2615	277	2	-	-	PUNCT
fnp-2615	277	3	ver	ver	PROPN
fnp-2615	277	4	,	,	PUNCT
fnp-2615	277	5	the	the	DET
fnp-2615	277	6	concept	concept	NOUN
fnp-2615	277	7	is	be	AUX
fnp-2615	277	8	emerging	emerge	VERB
fnp-2615	277	9	that	that	SCONJ
fnp-2615	277	10	pericytes	pericyte	NOUN
fnp-2615	277	11	and	and	CCONJ
fnp-2615	277	12	endothe	endothe	ADJ
fnp-2615	277	13	-	-	ADJ
fnp-2615	277	14	lial	lial	ADJ
fnp-2615	277	15	cells	cell	NOUN
fnp-2615	277	16	can	can	AUX
fnp-2615	277	17	signal	signal	VERB
fnp-2615	277	18	to	to	ADP
fnp-2615	277	19	neurons	neuron	NOUN
fnp-2615	277	20	by	by	ADP
fnp-2615	277	21	releasing	release	VERB
fnp-2615	277	22	certain	certain	ADJ
fnp-2615	277	23	specif	specif	NOUN
fnp-2615	277	24	-	-	ADJ
fnp-2615	277	25	ic	ic	INTJ
fnp-2615	277	26	molecular	molecular	ADJ
fnp-2615	277	27	cues	cue	NOUN
fnp-2615	277	28	.	.	PUNCT
fnp-2615	278	1	ideally	ideally	ADV
fnp-2615	278	2	,	,	PUNCT
fnp-2615	278	3	the	the	DET
fnp-2615	278	4	novel	novel	ADJ
fnp-2615	278	5	knowledge	knowledge	NOUN
fnp-2615	278	6	of	of	ADP
fnp-2615	278	7	genet	genet	NOUN
fnp-2615	278	8	-	-	PUNCT
fnp-2615	278	9	ic	ic	PROPN
fnp-2615	278	10	risk	risk	NOUN
fnp-2615	278	11	factors	factor	NOUN
fnp-2615	278	12	,	,	PUNCT
fnp-2615	278	13	molecular	molecular	ADJ
fnp-2615	278	14	mechanisms	mechanism	NOUN
fnp-2615	278	15	,	,	PUNCT
fnp-2615	278	16	cell	cell	NOUN
fnp-2615	278	17	and	and	CCONJ
fnp-2615	278	18	system	system	NOUN
fnp-2615	278	19	interactions	interaction	NOUN
fnp-2615	278	20	,	,	PUNCT
fnp-2615	278	21	as	as	ADV
fnp-2615	278	22	well	well	ADV
fnp-2615	278	23	as	as	ADP
fnp-2615	278	24	pathologic	pathologic	ADJ
fnp-2615	278	25	and	and	CCONJ
fnp-2615	278	26	imaging	imaging	NOUN
fnp-2615	278	27	hallmarks	hallmark	NOUN
fnp-2615	278	28	in	in	ADP
fnp-2615	278	29	cerebrovascular	cerebrovascular	ADJ
fnp-2615	278	30	diseases	disease	NOUN
fnp-2615	278	31	should	should	AUX
fnp-2615	278	32	translate	translate	VERB
fnp-2615	278	33	into	into	ADP
fnp-2615	278	34	curative	curative	ADJ
fnp-2615	278	35	treatments	treatment	NOUN
fnp-2615	278	36	that	that	PRON
fnp-2615	278	37	are	be	AUX
fnp-2615	278	38	currently	currently	ADV
fnp-2615	278	39	unavailable	unavailable	ADJ
fnp-2615	278	40	.	.	PUNCT
fnp-2615	279	1	acknowledgements	acknowledgement	NOUN
fnp-2615	279	2	supported	support	VERB
fnp-2615	279	3	by	by	ADP
fnp-2615	279	4	the	the	DET
fnp-2615	279	5	spanish	spanish	PROPN
fnp-2615	279	6	ministry	ministry	PROPN
fnp-2615	279	7	of	of	ADP
fnp-2615	279	8	science	science	PROPN
fnp-2615	279	9	,	,	PUNCT
fnp-2615	279	10	innovation	innovation	NOUN
fnp-2615	279	11	and	and	CCONJ
fnp-2615	279	12	universities	university	NOUN
fnp-2615	279	13	(	(	PUNCT
fnp-2615	279	14	saf2017	saf2017	NOUN
fnp-2615	279	15	-	-	PUNCT
fnp-2615	279	16	87459	87459	NUM
fnp-2615	279	17	-	-	PUNCT
fnp-2615	279	18	r	r	NOUN
fnp-2615	279	19	)	)	PUNCT
fnp-2615	279	20	.	.	PUNCT
fnp-2615	280	1	note	note	VERB
fnp-2615	280	2	i	i	PRON
fnp-2615	280	3	apologize	apologize	VERB
fnp-2615	280	4	to	to	ADP
fnp-2615	280	5	the	the	DET
fnp-2615	280	6	authors	author	NOUN
fnp-2615	280	7	that	that	PRON
fnp-2615	280	8	have	have	AUX
fnp-2615	280	9	provided	provide	VERB
fnp-2615	280	10	highly	highly	ADV
fnp-2615	280	11	valuable	valuable	ADJ
fnp-2615	280	12	contributions	contribution	NOUN
fnp-2615	280	13	in	in	ADP
fnp-2615	280	14	the	the	DET
fnp-2615	280	15	field	field	NOUN
fnp-2615	280	16	in	in	ADP
fnp-2615	280	17	2019	2019	NUM
fnp-2615	280	18	but	but	CCONJ
fnp-2615	280	19	could	could	AUX
fnp-2615	280	20	not	not	PART
fnp-2615	280	21	be	be	AUX
fnp-2615	280	22	cited	cite	VERB
fnp-2615	280	23	here	here	ADV
fnp-2615	280	24	due	due	ADP
fnp-2615	280	25	to	to	ADP
fnp-2615	280	26	limitations	limitation	NOUN
fnp-2615	280	27	in	in	ADP
fnp-2615	280	28	the	the	DET
fnp-2615	280	29	number	number	NOUN
fnp-2615	280	30	of	of	ADP
fnp-2615	280	31	selected	select	VERB
fnp-2615	280	32	references	reference	NOUN
fnp-2615	280	33	.	.	PUNCT
fnp-2615	281	1	references	reference	NOUN
fnp-2615	281	2	chen	chen	PROPN
fnp-2615	281	3	j	j	PROPN
fnp-2615	281	4	,	,	PUNCT
fnp-2615	281	5	van	van	PROPN
fnp-2615	281	6	gulden	gulden	NOUN
fnp-2615	281	7	s	s	PROPN
fnp-2615	281	8	,	,	PUNCT
fnp-2615	281	9	mcguire	mcguire	PROPN
fnp-2615	281	10	tl	tl	PROPN
fnp-2615	281	11	,	,	PUNCT
fnp-2615	281	12	fleming	fleming	PROPN
fnp-2615	281	13	ac	ac	PROPN
fnp-2615	281	14	,	,	PUNCT
fnp-2615	281	15	oka	oka	PROPN
fnp-2615	281	16	c	c	PROPN
fnp-2615	281	17	,	,	PUNCT
fnp-2615	281	18	kessler	kessler	PROPN
fnp-2615	281	19	ja	ja	PROPN
fnp-2615	281	20	,	,	PUNCT
fnp-2615	281	21	peng	peng	PROPN
fnp-2615	281	22	cy	cy	PROPN
fnp-2615	281	23	.	.	PROPN
fnp-2615	281	24	bmp	bmp	ADJ
fnp-2615	281	25	-	-	PUNCT
fnp-2615	281	26	responsive	responsive	ADJ
fnp-2615	281	27	protease	protease	NOUN
fnp-2615	281	28	htra1	htra1	NOUN
fnp-2615	281	29	is	be	AUX
fnp-2615	281	30	differentially	differentially	ADV
fnp-2615	281	31	expressed	express	VERB
fnp-2615	281	32	in	in	ADP
fnp-2615	281	33	astrocytes	astrocyte	NOUN
fnp-2615	281	34	and	and	CCONJ
fnp-2615	281	35	regulates	regulate	VERB
fnp-2615	281	36	astrocytic	astrocytic	ADJ
fnp-2615	281	37	development	development	NOUN
fnp-2615	281	38	and	and	CCONJ
fnp-2615	281	39	injury	injury	NOUN
fnp-2615	281	40	response	response	NOUN
fnp-2615	281	41	.	.	PUNCT
fnp-2615	282	1	j	j	PROPN
fnp-2615	282	2	neurosci	neurosci	PROPN
fnp-2615	282	3	.	.	PUNCT
fnp-2615	283	1	2018	2018	NUM
fnp-2615	283	2	;	;	PUNCT
fnp-2615	284	1	38:3840	38:3840	NUM
fnp-2615	284	2	-	-	SYM
fnp-2615	284	3	3857	3857	NUM
fnp-2615	284	4	.	.	PUNCT
fnp-2615	285	1	doi	doi	NOUN
fnp-2615	285	2	:	:	PUNCT
fnp-2615	285	3	10.1523	10.1523	NUM
fnp-2615	285	4	/	/	SYM
fnp-2615	285	5	jneurosci.2031	jneurosci.2031	PROPN
fnp-2615	285	6	-	-	PUNCT
fnp-2615	285	7	17.2018	17.2018	NUM
fnp-2615	285	8	.	.	PUNCT
fnp-2615	286	1	detter	detter	PROPN
fnp-2615	286	2	mr	mr	PROPN
fnp-2615	286	3	,	,	PUNCT
fnp-2615	286	4	snellings	snelling	NOUN
fnp-2615	286	5	da	da	PROPN
fnp-2615	286	6	,	,	PUNCT
fnp-2615	286	7	marchuk	marchuk	PROPN
fnp-2615	286	8	da	da	PROPN
fnp-2615	286	9	.	.	PROPN
fnp-2615	286	10	cerebral	cerebral	ADJ
fnp-2615	286	11	cavernous	cavernous	ADJ
fnp-2615	286	12	malformations	malformation	NOUN
fnp-2615	286	13	develop	develop	VERB
fnp-2615	286	14	through	through	ADP
fnp-2615	286	15	clonal	clonal	ADJ
fnp-2615	286	16	expansion	expansion	NOUN
fnp-2615	286	17	of	of	ADP
fnp-2615	286	18	mutant	mutant	ADJ
fnp-2615	286	19	endothelial	endothelial	ADJ
fnp-2615	286	20	cells	cell	NOUN
fnp-2615	286	21	.	.	PUNCT
fnp-2615	287	1	circ	circ	PROPN
fnp-2615	287	2	res	re	NOUN
fnp-2615	287	3	.	.	PROPN
fnp-2615	287	4	2018	2018	NUM
fnp-2615	287	5	;	;	PUNCT
fnp-2615	287	6	123(10):1143	123(10):1143	NUM
fnp-2615	287	7	-	-	SYM
fnp-2615	287	8	1151	1151	NUM
fnp-2615	287	9	.	.	PUNCT
fnp-2615	288	1	doi	doi	NOUN
fnp-2615	288	2	:	:	PUNCT
fnp-2615	288	3	10.1161	10.1161	NUM
fnp-2615	288	4	/	/	SYM
fnp-2615	288	5	circresaha.118.313970	circresaha.118.313970	NOUN
fnp-2615	288	6	.	.	PUNCT
fnp-2615	288	7	diéguez	diéguez	NOUN
fnp-2615	288	8	-	-	PUNCT
fnp-2615	288	9	hurtado	hurtado	NOUN
fnp-2615	288	10	r	r	NOUN
fnp-2615	288	11	,	,	PUNCT
fnp-2615	288	12	kato	kato	PROPN
fnp-2615	288	13	k	k	PROPN
fnp-2615	288	14	,	,	PUNCT
fnp-2615	288	15	giaimo	giaimo	PROPN
fnp-2615	288	16	bd	bd	PROPN
fnp-2615	288	17	,	,	PUNCT
fnp-2615	288	18	nieminen	nieminen	PROPN
fnp-2615	288	19	-	-	PUNCT
fnp-2615	288	20	kelhä	kelhä	PROPN
fnp-2615	288	21	m	m	PROPN
fnp-2615	288	22	,	,	PUNCT
fnp-2615	288	23	arf	arf	PROPN
fnp-2615	288	24	h	h	PROPN
fnp-2615	288	25	,	,	PUNCT
fnp-2615	288	26	ferrante	ferrante	PROPN
fnp-2615	288	27	f	f	PROPN
fnp-2615	288	28	,	,	PUNCT
fnp-2615	288	29	bartkuhn	bartkuhn	PROPN
fnp-2615	288	30	m	m	PROPN
fnp-2615	288	31	,	,	PUNCT
fnp-2615	288	32	zimmermann	zimmermann	PROPN
fnp-2615	288	33	t	t	PROPN
fnp-2615	288	34	,	,	PUNCT
fnp-2615	288	35	bixel	bixel	PROPN
fnp-2615	288	36	mg	mg	PROPN
fnp-2615	288	37	,	,	PUNCT
fnp-2615	288	38	eilken	eilken	VERB
fnp-2615	288	39	hm	hm	INTJ
fnp-2615	288	40	,	,	PUNCT
fnp-2615	288	41	adams	adams	PROPN
fnp-2615	288	42	s	s	PROPN
fnp-2615	288	43	,	,	PUNCT
fnp-2615	288	44	borggrefe	borggrefe	PROPN
fnp-2615	288	45	t	t	PROPN
fnp-2615	288	46	,	,	PUNCT
fnp-2615	288	47	vajkoczy	vajkoczy	PROPN
fnp-2615	288	48	p	p	X
fnp-2615	288	49	,	,	PUNCT
fnp-2615	288	50	adams	adams	PROPN
fnp-2615	288	51	rh	rh	PROPN
fnp-2615	288	52	.	.	PUNCT
fnp-2615	288	53	loss	loss	NOUN
fnp-2615	288	54	of	of	ADP
fnp-2615	288	55	the	the	DET
fnp-2615	288	56	transcription	transcription	NOUN
fnp-2615	288	57	factor	factor	NOUN
fnp-2615	288	58	rbpj	rbpj	PROPN
fnp-2615	288	59	induces	induce	VERB
fnp-2615	288	60	disease	disease	NOUN
fnp-2615	288	61	-	-	PUNCT
fnp-2615	288	62	promoting	promote	VERB
fnp-2615	288	63	properties	property	NOUN
fnp-2615	288	64	in	in	ADP
fnp-2615	288	65	brain	brain	NOUN
fnp-2615	288	66	pericytes	pericyte	NOUN
fnp-2615	288	67	.	.	PUNCT
fnp-2615	289	1	nat	nat	PROPN
fnp-2615	289	2	commun	commun	PROPN
fnp-2615	289	3	.	.	PROPN
fnp-2615	290	1	2019	2019	NUM
fnp-2615	290	2	;	;	PUNCT
fnp-2615	290	3	10(1):2817	10(1):2817	NUM
fnp-2615	290	4	.	.	PUNCT
fnp-2615	290	5	doi	doi	NOUN
fnp-2615	290	6	:	:	PUNCT
fnp-2615	290	7	10.1038	10.1038	NUM
fnp-2615	290	8	/	/	SYM
fnp-2615	290	9	s41467	s41467	NOUN
fnp-2615	290	10	-	-	PUNCT
fnp-2615	290	11	019	019	NUM
fnp-2615	290	12	-	-	PUNCT
fnp-2615	290	13	10643	10643	NUM
fnp-2615	290	14	-	-	PUNCT
fnp-2615	290	15	w.	w.	PROPN
fnp-2615	290	16	faraco	faraco	PROPN
fnp-2615	290	17	g	g	PROPN
fnp-2615	290	18	,	,	PUNCT
fnp-2615	290	19	brea	brea	PROPN
fnp-2615	290	20	d	d	PROPN
fnp-2615	290	21	,	,	PUNCT
fnp-2615	290	22	garcia	garcia	PROPN
fnp-2615	290	23	-	-	PUNCT
fnp-2615	290	24	bonilla	bonilla	PROPN
fnp-2615	290	25	l	l	PROPN
fnp-2615	290	26	,	,	PUNCT
fnp-2615	290	27	wang	wang	PROPN
fnp-2615	290	28	g	g	PROPN
fnp-2615	290	29	,	,	PUNCT
fnp-2615	290	30	racchumi	racchumi	VERB
fnp-2615	290	31	g	g	PROPN
fnp-2615	290	32	,	,	PUNCT
fnp-2615	290	33	chang	chang	PROPN
fnp-2615	290	34	h	h	PROPN
fnp-2615	290	35	,	,	PUNCT
fnp-2615	290	36	buendia	buendia	PROPN
fnp-2615	290	37	i	i	PROPN
fnp-2615	290	38	,	,	PUNCT
fnp-2615	290	39	santisteban	santisteban	NOUN
fnp-2615	290	40	mm	mm	PROPN
fnp-2615	290	41	,	,	PUNCT
fnp-2615	290	42	segarra	segarra	PROPN
fnp-2615	290	43	sg	sg	PROPN
fnp-2615	290	44	,	,	PUNCT
fnp-2615	290	45	koizumi	koizumi	PROPN
fnp-2615	290	46	k	k	PROPN
fnp-2615	290	47	,	,	PUNCT
fnp-2615	290	48	sugiyama	sugiyama	NOUN
fnp-2615	290	49	y	y	PROPN
fnp-2615	290	50	,	,	PUNCT
fnp-2615	290	51	murphy	murphy	PROPN
fnp-2615	290	52	m	m	PROPN
fnp-2615	290	53	,	,	PUNCT
fnp-2615	290	54	voss	voss	PROPN
fnp-2615	290	55	h	h	PROPN
fnp-2615	290	56	,	,	PUNCT
fnp-2615	290	57	anrather	anrather	PROPN
fnp-2615	290	58	j	j	PROPN
fnp-2615	290	59	,	,	PUNCT
fnp-2615	290	60	iadecola	iadecola	PROPN
fnp-2615	290	61	c.	c.	PROPN
fnp-2615	290	62	dietary	dietary	ADJ
fnp-2615	290	63	salt	salt	NOUN
fnp-2615	290	64	promotes	promote	VERB
fnp-2615	290	65	neurovascular	neurovascular	ADJ
fnp-2615	290	66	and	and	CCONJ
fnp-2615	290	67	cognitive	cognitive	ADJ
fnp-2615	290	68	dysfunction	dysfunction	NOUN
fnp-2615	290	69	through	through	ADP
fnp-2615	290	70	a	a	DET
fnp-2615	290	71	gut	gut	NOUN
fnp-2615	290	72	-	-	PUNCT
fnp-2615	290	73	initiated	initiate	VERB
fnp-2615	290	74	th17	th17	NOUN
fnp-2615	290	75	response	response	NOUN
fnp-2615	290	76	.	.	PUNCT
fnp-2615	291	1	nat	nat	PROPN
fnp-2615	291	2	neurosci	neurosci	PROPN
fnp-2615	291	3	.	.	PUNCT
fnp-2615	291	4	2018	2018	NUM
fnp-2615	291	5	;	;	PUNCT
fnp-2615	291	6	21(2):240	21(2):240	NUM
fnp-2615	291	7	-	-	SYM
fnp-2615	291	8	249	249	NUM
fnp-2615	291	9	.	.	PUNCT
fnp-2615	292	1	doi	doi	NOUN
fnp-2615	292	2	:	:	PUNCT
fnp-2615	292	3	10.1038	10.1038	NUM
fnp-2615	292	4	/	/	SYM
fnp-2615	292	5	s41593	s41593	PROPN
fnp-2615	292	6	-	-	PUNCT
fnp-2615	292	7	017	017	NUM
fnp-2615	292	8	-	-	PUNCT
fnp-2615	292	9	0059	0059	NUM
fnp-2615	292	10	-	-	PUNCT
fnp-2615	292	11	z.	z.	PROPN
fnp-2615	292	12	faraco	faraco	PROPN
fnp-2615	292	13	g	g	PROPN
fnp-2615	292	14	,	,	PUNCT
fnp-2615	292	15	hochrainer	hochrainer	PROPN
fnp-2615	292	16	k	k	PROPN
fnp-2615	292	17	,	,	PUNCT
fnp-2615	292	18	segarra	segarra	PROPN
fnp-2615	292	19	sg	sg	PROPN
fnp-2615	292	20	,	,	PUNCT
fnp-2615	292	21	schaeffer	schaeffer	PROPN
fnp-2615	292	22	s	s	PROPN
fnp-2615	292	23	,	,	PUNCT
fnp-2615	292	24	santisteban	santisteban	ADJ
fnp-2615	292	25	mm	mm	PROPN
fnp-2615	292	26	,	,	PUNCT
fnp-2615	292	27	menon	menon	PROPN
fnp-2615	292	28	a	a	PROPN
fnp-2615	292	29	,	,	PUNCT
fnp-2615	292	30	jiang	jiang	PROPN
fnp-2615	292	31	h	h	PROPN
fnp-2615	292	32	,	,	PUNCT
fnp-2615	292	33	holtzman	holtzman	ADJ
fnp-2615	292	34	dm	dm	PROPN
fnp-2615	292	35	,	,	PUNCT
fnp-2615	292	36	anrather	anrather	PROPN
fnp-2615	292	37	j	j	PROPN
fnp-2615	292	38	,	,	PUNCT
fnp-2615	292	39	iadecola	iadecola	PROPN
fnp-2615	292	40	c.	c.	PROPN
fnp-2615	292	41	dietary	dietary	ADJ
fnp-2615	292	42	salt	salt	NOUN
fnp-2615	292	43	promotes	promote	VERB
fnp-2615	292	44	cognitive	cognitive	ADJ
fnp-2615	292	45	impairment	impairment	NOUN
fnp-2615	292	46	through	through	ADP
fnp-2615	292	47	tau	tau	PROPN
fnp-2615	292	48	phosphorylation	phosphorylation	NOUN
fnp-2615	292	49	.	.	PUNCT
fnp-2615	293	1	nature	nature	NOUN
fnp-2615	293	2	.	.	PUNCT
fnp-2615	294	1	2019	2019	NUM
fnp-2615	294	2	oct;574(7780):686	oct;574(7780):686	NOUN
fnp-2615	294	3	-	-	PUNCT
fnp-2615	294	4	690	690	NUM
fnp-2615	294	5	.	.	PUNCT
fnp-2615	294	6	doi	doi	NOUN
fnp-2615	294	7	:	:	PUNCT
fnp-2615	294	8	10.1038	10.1038	NUM
fnp-2615	294	9	/	/	SYM
fnp-2615	294	10	s41586	s41586	PROPN
fnp-2615	294	11	-	-	PUNCT
fnp-2615	294	12	019	019	NUM
fnp-2615	294	13	-	-	PUNCT
fnp-2615	294	14	1688	1688	NUM
fnp-2615	294	15	-	-	PUNCT
fnp-2615	294	16	z.	z.	PROPN
fnp-2615	294	17	grand	grand	PROPN
fnp-2615	294	18	moursel	moursel	PROPN
fnp-2615	294	19	l	l	PROPN
fnp-2615	294	20	,	,	PUNCT
fnp-2615	294	21	van	van	PROPN
fnp-2615	294	22	der	der	PROPN
fnp-2615	294	23	graaf	graaf	PROPN
fnp-2615	294	24	lm	lm	PROPN
fnp-2615	294	25	,	,	PUNCT
fnp-2615	294	26	bulk	bulk	PROPN
fnp-2615	294	27	m	m	PROPN
fnp-2615	294	28	,	,	PUNCT
fnp-2615	294	29	van	van	PROPN
fnp-2615	294	30	roon	roon	PROPN
fnp-2615	294	31	-	-	PUNCT
fnp-2615	294	32	mom	mom	NOUN
fnp-2615	294	33	wmc	wmc	PROPN
fnp-2615	294	34	,	,	PUNCT
fnp-2615	294	35	van	van	PROPN
fnp-2615	294	36	der	der	PROPN
fnp-2615	294	37	weerd	weerd	PROPN
fnp-2615	294	38	l.	l.	PROPN
fnp-2615	294	39	osteopontin	osteopontin	PROPN
fnp-2615	294	40	and	and	CCONJ
fnp-2615	294	41	phospho	phospho	ADJ
fnp-2615	294	42	-	-	PUNCT
fnp-2615	294	43	smad2/3	smad2/3	NOUN
fnp-2615	294	44	are	be	AUX
fnp-2615	294	45	associated	associate	VERB
fnp-2615	294	46	with	with	ADP
fnp-2615	294	47	calcification	calcification	NOUN
fnp-2615	294	48	of	of	ADP
fnp-2615	294	49	vessels	vessel	NOUN
fnp-2615	294	50	in	in	ADP
fnp-2615	294	51	d	d	NOUN
fnp-2615	294	52	-	-	NOUN
fnp-2615	294	53	caa	caa	NOUN
fnp-2615	294	54	,	,	PUNCT
fnp-2615	294	55	an	an	DET
fnp-2615	294	56	hereditary	hereditary	ADJ
fnp-2615	294	57	cerebral	cerebral	ADJ
fnp-2615	294	58	amyloid	amyloid	NOUN
fnp-2615	294	59	angiopathy	angiopathy	ADJ
fnp-2615	294	60	.	.	PUNCT
fnp-2615	295	1	brain	brain	NOUN
fnp-2615	295	2	pathol	pathol	NOUN
fnp-2615	295	3	.	.	PUNCT
fnp-2615	296	1	2019	2019	NUM
fnp-2615	296	2	;	;	PUNCT
fnp-2615	296	3	29(6):793	29(6):793	NUM
fnp-2615	296	4	-	-	SYM
fnp-2615	296	5	802	802	NUM
fnp-2615	296	6	.	.	PUNCT
fnp-2615	296	7	doi	doi	NOUN
fnp-2615	296	8	:	:	PUNCT
fnp-2615	296	9	10.1111	10.1111	NUM
fnp-2615	296	10	/	/	SYM
fnp-2615	296	11	bpa.12721	bpa.12721	NOUN
fnp-2615	296	12	.	.	PUNCT
fnp-2615	296	13	gravesteijn	gravesteijn	PROPN
fnp-2615	296	14	g	g	PROPN
fnp-2615	296	15	,	,	PUNCT
fnp-2615	296	16	munting	munte	VERB
fnp-2615	296	17	lp	lp	ADP
fnp-2615	296	18	,	,	PUNCT
fnp-2615	296	19	overzier	overzier	NOUN
fnp-2615	296	20	m	m	PROPN
fnp-2615	296	21	,	,	PUNCT
fnp-2615	296	22	mulder	mulder	PROPN
fnp-2615	296	23	aa	aa	PROPN
fnp-2615	296	24	,	,	PUNCT
fnp-2615	296	25	hegeman	hegeman	ADJ
fnp-2615	296	26	i	i	PRON
fnp-2615	296	27	,	,	PUNCT
fnp-2615	296	28	derieppe	derieppe	PROPN
fnp-2615	296	29	m	m	PROPN
fnp-2615	296	30	,	,	PUNCT
fnp-2615	296	31	koster	koster	PROPN
fnp-2615	296	32	aj	aj	PROPN
fnp-2615	296	33	,	,	PUNCT
fnp-2615	296	34	van	van	PROPN
fnp-2615	296	35	duinen	duinen	PROPN
fnp-2615	296	36	sg	sg	PROPN
fnp-2615	296	37	,	,	PUNCT
fnp-2615	296	38	meijer	meijer	PROPN
fnp-2615	296	39	oc	oc	PROPN
fnp-2615	296	40	,	,	PUNCT
fnp-2615	296	41	aartsma	aartsma	PROPN
fnp-2615	296	42	-	-	PUNCT
fnp-2615	296	43	rus	rus	PROPN
fnp-2615	296	44	a	a	PRON
fnp-2615	296	45	,	,	PUNCT
fnp-2615	296	46	van	van	PROPN
fnp-2615	296	47	der	der	PROPN
fnp-2615	296	48	weerd	weerd	PROPN
fnp-2615	296	49	l	l	PROPN
fnp-2615	296	50	,	,	PUNCT
fnp-2615	296	51	jost	jost	PROPN
fnp-2615	296	52	cr	cr	PROPN
fnp-2615	296	53	,	,	PUNCT
fnp-2615	296	54	van	van	PROPN
fnp-2615	296	55	den	den	PROPN
fnp-2615	296	56	maagdenberg	maagdenberg	PROPN
fnp-2615	296	57	amjm	amjm	PROPN
fnp-2615	296	58	,	,	PUNCT
fnp-2615	296	59	rutten	rutten	PROPN
fnp-2615	296	60	jw	jw	PROPN
fnp-2615	296	61	,	,	PUNCT
fnp-2615	296	62	lesnik	lesnik	PROPN
fnp-2615	296	63	oberstein	oberstein	PROPN
fnp-2615	296	64	saj	saj	PROPN
fnp-2615	296	65	.	.	PUNCT
fnp-2615	296	66	progression	progression	NOUN
fnp-2615	296	67	and	and	CCONJ
fnp-2615	296	68	classification	classification	NOUN
fnp-2615	296	69	of	of	ADP
fnp-2615	296	70	granular	granular	ADJ
fnp-2615	296	71	osmiophilic	osmiophilic	NOUN
fnp-2615	296	72	material	material	NOUN
fnp-2615	296	73	(	(	PUNCT
fnp-2615	296	74	gom	gom	NOUN
fnp-2615	296	75	)	)	PUNCT
fnp-2615	296	76	deposits	deposit	NOUN
fnp-2615	296	77	in	in	ADP
fnp-2615	296	78	functionally	functionally	ADV
fnp-2615	296	79	characterized	characterize	VERB
fnp-2615	296	80	human	human	ADJ
fnp-2615	296	81	notch3	notch3	ADJ
fnp-2615	296	82	transgenic	transgenic	NOUN
fnp-2615	296	83	mice	mouse	NOUN
fnp-2615	296	84	.	.	PUNCT
fnp-2615	297	1	transl	transl	PROPN
fnp-2615	297	2	stroke	stroke	NOUN
fnp-2615	297	3	res	re	NOUN
fnp-2615	297	4	.	.	PROPN
fnp-2615	298	1	2019	2019	NUM
fnp-2615	298	2	oct	oct	NOUN
fnp-2615	298	3	30	30	NUM
fnp-2615	298	4	.	.	PUNCT
fnp-2615	299	1	doi	doi	NOUN
fnp-2615	299	2	:	:	PUNCT
fnp-2615	299	3	10.1007	10.1007	NUM
fnp-2615	299	4	/	/	SYM
fnp-2615	299	5	s12975	s12975	NOUN
fnp-2615	299	6	-	-	PUNCT
fnp-2615	299	7	019	019	NUM
fnp-2615	299	8	-	-	PUNCT
fnp-2615	299	9	00742	00742	NUM
fnp-2615	299	10	-	-	PUNCT
fnp-2615	299	11	7	7	NUM
fnp-2615	299	12	.	.	PUNCT
fnp-2615	300	1	hase	hase	PROPN
fnp-2615	300	2	y	y	PROPN
fnp-2615	300	3	,	,	PUNCT
fnp-2615	300	4	ding	de	VERB
fnp-2615	300	5	r	r	NOUN
fnp-2615	300	6	,	,	PUNCT
fnp-2615	300	7	harrison	harrison	NOUN
fnp-2615	300	8	g	g	PROPN
fnp-2615	300	9	,	,	PUNCT
fnp-2615	300	10	hawthorne	hawthorne	NOUN
fnp-2615	300	11	e	e	NOUN
fnp-2615	300	12	,	,	PUNCT
fnp-2615	300	13	king	king	PROPN
fnp-2615	300	14	a	a	NOUN
fnp-2615	300	15	,	,	PUNCT
fnp-2615	300	16	gettings	getting	NOUN
fnp-2615	300	17	s	s	NOUN
fnp-2615	300	18	,	,	PUNCT
fnp-2615	300	19	platten	platten	PROPN
fnp-2615	300	20	c	c	PROPN
fnp-2615	300	21	,	,	PUNCT
fnp-2615	300	22	stevenson	stevenson	PROPN
fnp-2615	300	23	w	w	PROPN
fnp-2615	300	24	,	,	PUNCT
fnp-2615	300	25	craggs	craggs	PROPN
fnp-2615	300	26	ljl	ljl	PROPN
fnp-2615	300	27	,	,	PUNCT
fnp-2615	300	28	kalaria	kalaria	PROPN
fnp-2615	300	29	rn	rn	PROPN
fnp-2615	300	30	.	.	PROPN
fnp-2615	300	31	white	white	PROPN
fnp-2615	300	32	matter	matter	PROPN
fnp-2615	300	33	capillaries	capillary	NOUN
fnp-2615	300	34	in	in	ADP
fnp-2615	300	35	vascular	vascular	ADJ
fnp-2615	300	36	and	and	CCONJ
fnp-2615	300	37	neurodegenerative	neurodegenerative	ADJ
fnp-2615	300	38	dementias	dementia	NOUN
fnp-2615	300	39	.	.	PUNCT
fnp-2615	301	1	acta	acta	PROPN
fnp-2615	301	2	neuropathol	neuropathol	PROPN
fnp-2615	301	3	commun	commun	PROPN
fnp-2615	301	4	.	.	PUNCT
fnp-2615	302	1	2019	2019	NUM
fnp-2615	302	2	;	;	PUNCT
fnp-2615	303	1	7(1):16	7(1):16	NUM
fnp-2615	303	2	.	.	PUNCT
fnp-2615	304	1	doi	doi	NOUN
fnp-2615	304	2	:	:	PUNCT
fnp-2615	304	3	10.1186	10.1186	NUM
fnp-2615	304	4	/	/	SYM
fnp-2615	304	5	s40478	s40478	PROPN
fnp-2615	304	6	-	-	PUNCT
fnp-2615	304	7	019	019	NUM
fnp-2615	304	8	-	-	PUNCT
fnp-2615	304	9	0666	0666	NUM
fnp-2615	304	10	-	-	PUNCT
fnp-2615	304	11	x.	x.	NOUN
fnp-2615	304	12	kelleher	kelleher	PROPN
fnp-2615	304	13	j	j	PROPN
fnp-2615	304	14	,	,	PUNCT
fnp-2615	304	15	dickinson	dickinson	PROPN
fnp-2615	304	16	a	a	PROPN
fnp-2615	304	17	,	,	PUNCT
fnp-2615	304	18	cain	cain	PROPN
fnp-2615	304	19	s	s	PROPN
fnp-2615	304	20	,	,	PUNCT
fnp-2615	304	21	hu	hu	PROPN
fnp-2615	304	22	y	y	PROPN
fnp-2615	304	23	,	,	PUNCT
fnp-2615	304	24	bates	bate	NOUN
fnp-2615	304	25	n	n	CCONJ
fnp-2615	304	26	,	,	PUNCT
fnp-2615	304	27	harvey	harvey	PROPN
fnp-2615	304	28	a	a	PROPN
fnp-2615	304	29	,	,	PUNCT
fnp-2615	304	30	ren	ren	PROPN
fnp-2615	304	31	j	j	PROPN
fnp-2615	304	32	,	,	PUNCT
fnp-2615	304	33	zhang	zhang	PROPN
fnp-2615	304	34	w	w	PROPN
fnp-2615	304	35	,	,	PUNCT
fnp-2615	304	36	moreton	moreton	PROPN
fnp-2615	304	37	fc	fc	PROPN
fnp-2615	304	38	,	,	PUNCT
fnp-2615	304	39	muir	muir	PROPN
fnp-2615	304	40	kw	kw	PROPN
fnp-2615	304	41	,	,	PUNCT
fnp-2615	304	42	ward	ward	NOUN
fnp-2615	304	43	c	c	NOUN
fnp-2615	304	44	,	,	PUNCT
fnp-2615	304	45	touyz	touyz	PROPN
fnp-2615	304	46	rm	rm	PROPN
fnp-2615	304	47	,	,	PUNCT
fnp-2615	304	48	sharma	sharma	PROPN
fnp-2615	305	1	p	p	X
fnp-2615	305	2	,	,	PUNCT
fnp-2615	305	3	xu	xu	PROPN
fnp-2615	305	4	q	q	X
fnp-2615	305	5	,	,	PUNCT
fnp-2615	305	6	kimber	kimber	PROPN
fnp-2615	305	7	sj	sj	PROPN
fnp-2615	305	8	,	,	PUNCT
fnp-2615	305	9	wang	wang	PROPN
fnp-2615	305	10	t.	t.	PROPN
fnp-2615	305	11	patient	patient	NOUN
fnp-2615	305	12	-	-	PUNCT
fnp-2615	305	13	specific	specific	ADJ
fnp-2615	305	14	ipsc	ipsc	NOUN
fnp-2615	305	15	model	model	NOUN
fnp-2615	305	16	of	of	ADP
fnp-2615	305	17	a	a	DET
fnp-2615	305	18	genetic	genetic	ADJ
fnp-2615	305	19	vascular	vascular	ADJ
fnp-2615	305	20	dementia	dementia	NOUN
fnp-2615	305	21	syndrome	syndrome	NOUN
fnp-2615	305	22	reveals	reveal	VERB
fnp-2615	305	23	failure	failure	NOUN
fnp-2615	305	24	of	of	ADP
fnp-2615	305	25	mural	mural	ADJ
fnp-2615	305	26	cells	cell	NOUN
fnp-2615	305	27	to	to	PART
fnp-2615	305	28	stabilize	stabilize	VERB
fnp-2615	305	29	capillary	capillary	ADJ
fnp-2615	305	30	structures	structure	NOUN
fnp-2615	305	31	.	.	PUNCT
fnp-2615	306	1	stem	stem	NOUN
fnp-2615	306	2	cell	cell	NOUN
fnp-2615	306	3	reports	report	NOUN
fnp-2615	306	4	.	.	PUNCT
fnp-2615	307	1	2019	2019	NUM
fnp-2615	307	2	;	;	PUNCT
fnp-2615	308	1	13(5):817	13(5):817	PROPN
fnp-2615	308	2	-	-	PUNCT
fnp-2615	308	3	831	831	NUM
fnp-2615	308	4	.	.	PUNCT
fnp-2615	309	1	doi	doi	NOUN
fnp-2615	309	2	:	:	PUNCT
fnp-2615	309	3	10.1016	10.1016	NUM
fnp-2615	309	4	/	/	SYM
fnp-2615	309	5	j.stemcr.2019.10.004	j.stemcr.2019.10.004	PROPN
fnp-2615	309	6	.	.	PUNCT
fnp-2615	310	1	liu	liu	PROPN
fnp-2615	310	2	xx	xx	PROPN
fnp-2615	310	3	,	,	PUNCT
fnp-2615	310	4	yang	yang	PROPN
fnp-2615	310	5	l	l	PROPN
fnp-2615	310	6	,	,	PUNCT
fnp-2615	310	7	shao	shao	PROPN
fnp-2615	310	8	lx	lx	PROPN
fnp-2615	310	9	,	,	PUNCT
fnp-2615	310	10	he	he	PRON
fnp-2615	310	11	y	y	PROPN
fnp-2615	310	12	,	,	PUNCT
fnp-2615	310	13	wu	wu	PROPN
fnp-2615	310	14	g	g	PROPN
fnp-2615	310	15	,	,	PUNCT
fnp-2615	310	16	bao	bao	PROPN
fnp-2615	310	17	yh	yh	PROPN
fnp-2615	310	18	,	,	PUNCT
fnp-2615	310	19	lu	lu	PROPN
fnp-2615	310	20	nn	nn	PROPN
fnp-2615	310	21	,	,	PUNCT
fnp-2615	310	22	gong	gong	PROPN
fnp-2615	310	23	dm	dm	PROPN
fnp-2615	310	24	,	,	PUNCT
fnp-2615	310	25	lu	lu	PROPN
fnp-2615	310	26	yp	yp	PROPN
fnp-2615	310	27	,	,	PUNCT
fnp-2615	310	28	cui	cui	VERB
fnp-2615	310	29	tt	tt	PROPN
fnp-2615	310	30	,	,	PUNCT
fnp-2615	310	31	sun	sun	PROPN
fnp-2615	310	32	nh	nh	PROPN
fnp-2615	310	33	,	,	PUNCT
fnp-2615	310	34	chen	chen	PROPN
fnp-2615	310	35	dy	dy	PROPN
fnp-2615	310	36	,	,	PUNCT
fnp-2615	310	37	shi	shi	PROPN
fnp-2615	310	38	wx	wx	PROPN
fnp-2615	310	39	,	,	PUNCT
fnp-2615	310	40	fukunaga	fukunaga	PROPN
fnp-2615	310	41	k	k	PROPN
fnp-2615	310	42	,	,	PUNCT
fnp-2615	310	43	chen	chen	PROPN
fnp-2615	310	44	hs	hs	PROPN
fnp-2615	310	45	,	,	PUNCT
fnp-2615	310	46	chen	chen	PROPN
fnp-2615	310	47	z	z	PROPN
fnp-2615	310	48	,	,	PUNCT
fnp-2615	310	49	han	han	PROPN
fnp-2615	310	50	f	f	PROPN
fnp-2615	310	51	,	,	PUNCT
fnp-2615	310	52	lu	lu	PROPN
fnp-2615	310	53	ym	ym	PROPN
fnp-2615	310	54	.	.	PUNCT
fnp-2615	311	1	endothelial	endothelial	ADJ
fnp-2615	311	2	cdk5	cdk5	PROPN
fnp-2615	311	3	deficit	deficit	NOUN
fnp-2615	311	4	leads	lead	VERB
fnp-2615	311	5	to	to	ADP
fnp-2615	311	6	the	the	DET
fnp-2615	311	7	development	development	NOUN
fnp-2615	311	8	of	of	ADP
fnp-2615	311	9	spontaneous	spontaneous	ADJ
fnp-2615	311	10	epilepsy	epilepsy	NOUN
fnp-2615	311	11	through	through	ADP
fnp-2615	311	12	cxcl1	cxcl1	PROPN
fnp-2615	311	13	/	/	SYM
fnp-2615	311	14	cxcr2	cxcr2	NOUN
fnp-2615	311	15	-	-	PUNCT
fnp-2615	311	16	mediated	mediate	VERB
fnp-2615	311	17	reactive	reactive	ADJ
fnp-2615	311	18	astrogliosis	astrogliosis	NOUN
fnp-2615	311	19	.	.	PUNCT
fnp-2615	312	1	j	j	PROPN
fnp-2615	312	2	exp	exp	NOUN
fnp-2615	312	3	med	med	PROPN
fnp-2615	312	4	.	.	PUNCT
fnp-2615	312	5	2020	2020	NUM
fnp-2615	312	6	;	;	PUNCT
fnp-2615	312	7	217(1	217(1	NUM
fnp-2615	312	8	)	)	PUNCT
fnp-2615	312	9	.	.	PUNCT
fnp-2615	313	1	pii	pii	PROPN
fnp-2615	313	2	:	:	PUNCT
fnp-2615	313	3	e20180992	e20180992	ADJ
fnp-2615	313	4	.	.	PUNCT
fnp-2615	313	5	doi	doi	NOUN
fnp-2615	313	6	:	:	PUNCT
fnp-2615	313	7	10.1084	10.1084	NUM
fnp-2615	313	8	/	/	SYM
fnp-2615	313	9	jem.20180992	jem.20180992	NUM
fnp-2615	313	10	.	.	PUNCT
fnp-2615	313	11	malinverno	malinverno	PROPN
fnp-2615	313	12	m	m	PROPN
fnp-2615	313	13	,	,	PUNCT
fnp-2615	313	14	maderna	maderna	VERB
fnp-2615	313	15	c	c	NOUN
fnp-2615	313	16	,	,	PUNCT
fnp-2615	313	17	abu	abu	PROPN
fnp-2615	313	18	taha	taha	PROPN
fnp-2615	314	1	a	a	PRON
fnp-2615	314	2	,	,	PUNCT
fnp-2615	314	3	corada	corada	PROPN
fnp-2615	314	4	m	m	PROPN
fnp-2615	314	5	,	,	PUNCT
fnp-2615	314	6	orsenigo	orsenigo	PROPN
fnp-2615	314	7	f	f	PROPN
fnp-2615	314	8	,	,	PUNCT
fnp-2615	314	9	valentino	valentino	PROPN
fnp-2615	314	10	m	m	PROPN
fnp-2615	314	11	,	,	PUNCT
fnp-2615	314	12	pisati	pisati	PROPN
fnp-2615	314	13	f	f	PROPN
fnp-2615	314	14	,	,	PUNCT
fnp-2615	314	15	fusco	fusco	PROPN
fnp-2615	314	16	c	c	PROPN
fnp-2615	314	17	,	,	PUNCT
fnp-2615	314	18	graziano	graziano	PROPN
fnp-2615	314	19	p	p	NOUN
fnp-2615	314	20	,	,	PUNCT
fnp-2615	314	21	giannotta	giannotta	PROPN
fnp-2615	314	22	m	m	PROPN
fnp-2615	314	23	,	,	PUNCT
fnp-2615	314	24	yu	yu	PROPN
fnp-2615	314	25	qc	qc	PROPN
fnp-2615	314	26	,	,	PUNCT
fnp-2615	314	27	zeng	zeng	PROPN
fnp-2615	314	28	ya	ya	PROPN
fnp-2615	314	29	,	,	PUNCT
fnp-2615	314	30	lampugnani	lampugnani	VERB
fnp-2615	314	31	mg	mg	PROPN
fnp-2615	314	32	,	,	PUNCT
fnp-2615	314	33	magnusson	magnusson	PROPN
fnp-2615	314	34	pu	pu	PROPN
fnp-2615	314	35	,	,	PUNCT
fnp-2615	314	36	dejana	dejana	PROPN
fnp-2615	314	37	e.	e.	PROPN
fnp-2615	314	38	endothelial	endothelial	PROPN
fnp-2615	314	39	cell	cell	PROPN
fnp-2615	314	40	clonal	clonal	ADJ
fnp-2615	314	41	expansion	expansion	NOUN
fnp-2615	314	42	in	in	ADP
fnp-2615	314	43	the	the	DET
fnp-2615	314	44	development	development	NOUN
fnp-2615	314	45	of	of	ADP
fnp-2615	314	46	cerebral	cerebral	ADJ
fnp-2615	314	47	cavernous	cavernous	ADJ
fnp-2615	314	48	malformations	malformation	NOUN
fnp-2615	314	49	.	.	PUNCT
fnp-2615	315	1	nat	nat	PROPN
fnp-2615	315	2	commun	commun	PROPN
fnp-2615	315	3	.	.	PROPN
fnp-2615	315	4	2019	2019	NUM
fnp-2615	315	5	;	;	PUNCT
fnp-2615	315	6	10(1):2761	10(1):2761	NUM
fnp-2615	315	7	.	.	PUNCT
fnp-2615	316	1	doi	doi	NOUN
fnp-2615	316	2	:	:	PUNCT
fnp-2615	316	3	10.1038	10.1038	NUM
fnp-2615	316	4	/	/	SYM
fnp-2615	316	5	s41467	s41467	NOUN
fnp-2615	316	6	-	-	PUNCT
fnp-2615	316	7	019	019	NUM
fnp-2615	316	8	-	-	PUNCT
fnp-2615	316	9	10707	10707	NUM
fnp-2615	316	10	-	-	PUNCT
fnp-2615	316	11	x.	x.	NOUN
fnp-2615	316	12	manavski	manavski	PROPN
fnp-2615	316	13	y	y	PROPN
fnp-2615	316	14	,	,	PUNCT
fnp-2615	316	15	lucas	lucas	PROPN
fnp-2615	316	16	t	t	PROPN
fnp-2615	316	17	,	,	PUNCT
fnp-2615	316	18	glaser	glaser	PROPN
fnp-2615	316	19	sf	sf	PROPN
fnp-2615	316	20	,	,	PUNCT
fnp-2615	316	21	dorsheimer	dorsheimer	NOUN
fnp-2615	316	22	l	l	NOUN
fnp-2615	316	23	,	,	PUNCT
fnp-2615	316	24	günther	günther	NOUN
fnp-2615	316	25	s	s	PROPN
fnp-2615	316	26	,	,	PUNCT
fnp-2615	316	27	braun	braun	PROPN
fnp-2615	316	28	t	t	PROPN
fnp-2615	316	29	,	,	PUNCT
fnp-2615	316	30	rieger	rieger	PROPN
fnp-2615	316	31	ma	ma	PROPN
fnp-2615	316	32	,	,	PUNCT
fnp-2615	316	33	zeiher	zeiher	PROPN
fnp-2615	316	34	am	am	PROPN
fnp-2615	316	35	,	,	PUNCT
fnp-2615	316	36	boon	boon	PROPN
fnp-2615	316	37	ra	ra	PROPN
fnp-2615	316	38	,	,	PUNCT
fnp-2615	316	39	dimmeler	dimmeler	PROPN
fnp-2615	316	40	s.	s.	PROPN
fnp-2615	316	41	clonal	clonal	PROPN
fnp-2615	316	42	expansion	expansion	NOUN
fnp-2615	316	43	of	of	ADP
fnp-2615	316	44	endothelial	endothelial	ADJ
fnp-2615	316	45	cells	cell	NOUN
fnp-2615	316	46	contributes	contribute	VERB
fnp-2615	316	47	to	to	ADP
fnp-2615	316	48	ischemia	ischemia	NOUN
fnp-2615	316	49	-	-	PUNCT
fnp-2615	316	50	induced	induce	VERB
fnp-2615	316	51	neovascularization	neovascularization	NOUN
fnp-2615	316	52	.	.	PUNCT
fnp-2615	317	1	circ	circ	PROPN
fnp-2615	317	2	res	re	NOUN
fnp-2615	317	3	.	.	PROPN
fnp-2615	317	4	2018	2018	NUM
fnp-2615	317	5	;	;	PUNCT
fnp-2615	317	6	122(5):670	122(5):670	NUM
fnp-2615	317	7	-	-	SYM
fnp-2615	317	8	677	677	NUM
fnp-2615	317	9	.	.	PUNCT
fnp-2615	318	1	doi	doi	NOUN
fnp-2615	318	2	:	:	PUNCT
fnp-2615	318	3	10.1161	10.1161	NUM
fnp-2615	318	4	/	/	SYM
fnp-2615	318	5	circresaha.117.312310	circresaha.117.312310	PROPN
fnp-2615	318	6	.	.	PUNCT
fnp-2615	319	1	mishra	mishra	PROPN
fnp-2615	319	2	a	a	PROPN
fnp-2615	319	3	,	,	PUNCT
fnp-2615	319	4	chauhan	chauhan	PROPN
fnp-2615	319	5	g	g	PROPN
fnp-2615	319	6	,	,	PUNCT
fnp-2615	319	7	violleau	violleau	PROPN
fnp-2615	319	8	mh	mh	PROPN
fnp-2615	319	9	,	,	PUNCT
fnp-2615	319	10	vojinovic	vojinovic	PROPN
fnp-2615	319	11	d	d	PROPN
fnp-2615	319	12	,	,	PUNCT
fnp-2615	319	13	jian	jian	PROPN
fnp-2615	319	14	x	x	PROPN
fnp-2615	319	15	,	,	PUNCT
fnp-2615	319	16	bis	bis	PROPN
fnp-2615	319	17	jc	jc	PROPN
fnp-2615	319	18	,	,	PUNCT
fnp-2615	319	19	li	li	PROPN
fnp-2615	319	20	s	s	PROPN
fnp-2615	319	21	,	,	PUNCT
fnp-2615	319	22	saba	saba	PROPN
fnp-2615	319	23	y	y	PROPN
fnp-2615	319	24	,	,	PUNCT
fnp-2615	319	25	grenier	grenier	NOUN
fnp-2615	319	26	-	-	PUNCT
fnp-2615	319	27	boley	boley	PROPN
fnp-2615	319	28	b	b	PROPN
fnp-2615	319	29	,	,	PUNCT
fnp-2615	319	30	yang	yang	PROPN
fnp-2615	319	31	q	q	PROPN
fnp-2615	319	32	,	,	PUNCT
fnp-2615	319	33	bartz	bartz	PROPN
fnp-2615	319	34	tm	tm	PROPN
fnp-2615	319	35	,	,	PUNCT
fnp-2615	319	36	hofer	hofer	PROPN
fnp-2615	319	37	e	e	PROPN
fnp-2615	319	38	,	,	PUNCT
fnp-2615	319	39	soumaré	soumaré	VERB
fnp-2615	319	40	a	a	PRON
fnp-2615	319	41	,	,	PUNCT
fnp-2615	319	42	peng	peng	PROPN
fnp-2615	319	43	f	f	PROPN
fnp-2615	319	44	,	,	PUNCT
fnp-2615	319	45	duperron	duperron	ADJ
fnp-2615	319	46	mg	mg	PROPN
fnp-2615	319	47	,	,	PUNCT
fnp-2615	319	48	foglio	foglio	PROPN
fnp-2615	319	49	m	m	PROPN
fnp-2615	319	50	,	,	PUNCT
fnp-2615	319	51	mosley	mosley	PROPN
fnp-2615	319	52	th	th	PROPN
fnp-2615	319	53	,	,	PUNCT
fnp-2615	319	54	schmidt	schmidt	PROPN
fnp-2615	319	55	r	r	PROPN
fnp-2615	319	56	,	,	PUNCT
fnp-2615	319	57	psaty	psaty	NOUN
fnp-2615	319	58	bm	bm	PROPN
fnp-2615	319	59	,	,	PUNCT
fnp-2615	319	60	launer	launer	PROPN
fnp-2615	319	61	lj	lj	PROPN
fnp-2615	319	62	,	,	PUNCT
fnp-2615	319	63	boerwinkle	boerwinkle	NOUN
fnp-2615	319	64	e	e	PROPN
fnp-2615	319	65	,	,	PUNCT
fnp-2615	319	66	zhu	zhu	PROPN
fnp-2615	319	67	y	y	PROPN
fnp-2615	319	68	,	,	PUNCT
fnp-2615	319	69	mazoyer	mazoyer	NOUN
fnp-2615	319	70	b	b	NOUN
fnp-2615	319	71	,	,	PUNCT
fnp-2615	319	72	lathrop	lathrop	PROPN
fnp-2615	319	73	m	m	PROPN
fnp-2615	319	74	,	,	PUNCT
fnp-2615	319	75	bellenguez	bellenguez	PROPN
fnp-2615	319	76	c	c	AUX
fnp-2615	319	77	,	,	PUNCT
fnp-2615	319	78	van	van	PROPN
fnp-2615	319	79	duijn	duijn	PROPN
fnp-2615	319	80	cm	cm	PROPN
fnp-2615	319	81	,	,	PUNCT
fnp-2615	319	82	ikram	ikram	PROPN
fnp-2615	319	83	ma	ma	PROPN
fnp-2615	319	84	,	,	PUNCT
fnp-2615	319	85	schmidt	schmidt	PROPN
fnp-2615	319	86	h	h	PROPN
fnp-2615	319	87	,	,	PUNCT
fnp-2615	319	88	longstreth	longstreth	PROPN
fnp-2615	319	89	wt	wt	PROPN
fnp-2615	319	90	,	,	PUNCT
fnp-2615	319	91	fornage	fornage	NOUN
fnp-2615	319	92	m	m	PROPN
fnp-2615	319	93	,	,	PUNCT
fnp-2615	319	94	seshadri	seshadri	PROPN
fnp-2615	319	95	s	s	PROPN
fnp-2615	319	96	,	,	PUNCT
fnp-2615	319	97	joutel	joutel	NOUN
fnp-2615	319	98	a	a	PRON
fnp-2615	319	99	,	,	PUNCT
fnp-2615	319	100	tzourio	tzourio	NOUN
fnp-2615	319	101	c	c	NOUN
fnp-2615	319	102	,	,	PUNCT
fnp-2615	319	103	debette	debette	PROPN
fnp-2615	319	104	s.	s.	PROPN
fnp-2615	319	105	association	association	PROPN
fnp-2615	319	106	of	of	ADP
fnp-2615	319	107	variants	variant	NOUN
fnp-2615	319	108	in	in	ADP
fnp-2615	319	109	htra1	htra1	NOUN
fnp-2615	319	110	and	and	CCONJ
fnp-2615	319	111	notch3	notch3	PROPN
fnp-2615	319	112	with	with	ADP
fnp-2615	319	113	mri	mri	NOUN
fnp-2615	319	114	-	-	PUNCT
fnp-2615	319	115	defined	define	VERB
fnp-2615	319	116	extremes	extreme	NOUN
fnp-2615	319	117	of	of	ADP
fnp-2615	319	118	cerebral	cerebral	ADJ
fnp-2615	319	119	small	small	ADJ
fnp-2615	319	120	vessel	vessel	NOUN
fnp-2615	319	121	disease	disease	NOUN
fnp-2615	319	122	in	in	ADP
fnp-2615	319	123	older	old	ADJ
fnp-2615	319	124	subjects	subject	NOUN
fnp-2615	319	125	.	.	PUNCT
fnp-2615	320	1	brain	brain	NOUN
fnp-2615	320	2	.	.	PUNCT
fnp-2615	321	1	2019	2019	NUM
fnp-2615	321	2	;	;	PUNCT
fnp-2615	321	3	142(4):1009	142(4):1009	NUM
fnp-2615	321	4	-	-	SYM
fnp-2615	321	5	1023	1023	NUM
fnp-2615	321	6	.	.	PUNCT
fnp-2615	322	1	doi	doi	NOUN
fnp-2615	322	2	:	:	PUNCT
fnp-2615	322	3	10.1093	10.1093	NUM
fnp-2615	322	4	/	/	SYM
fnp-2615	322	5	brain	brain	NOUN
fnp-2615	322	6	/	/	SYM
fnp-2615	322	7	awz024	awz024	PROPN
fnp-2615	322	8	.	.	PUNCT
fnp-2615	323	1	muhire	muhire	NOUN
fnp-2615	323	2	g	g	PROPN
fnp-2615	323	3	,	,	PUNCT
fnp-2615	323	4	iulita	iulita	PROPN
fnp-2615	323	5	mf	mf	X
fnp-2615	323	6	,	,	PUNCT
fnp-2615	323	7	vallerand	vallerand	NOUN
fnp-2615	323	8	d	d	PROPN
fnp-2615	323	9	,	,	PUNCT
fnp-2615	323	10	youwakim	youwakim	PROPN
fnp-2615	323	11	j	j	PROPN
fnp-2615	323	12	,	,	PUNCT
fnp-2615	323	13	gratuze	gratuze	PROPN
fnp-2615	323	14	m	m	PROPN
fnp-2615	323	15	,	,	PUNCT
fnp-2615	323	16	petry	petry	PROPN
fnp-2615	323	17	fr	fr	PROPN
fnp-2615	323	18	,	,	PUNCT
fnp-2615	323	19	planel	planel	VERB
fnp-2615	323	20	e	e	NOUN
fnp-2615	323	21	,	,	PUNCT
fnp-2615	323	22	ferland	ferland	NOUN
fnp-2615	323	23	g	g	NOUN
fnp-2615	323	24	,	,	PUNCT
fnp-2615	323	25	girouard	girouard	NOUN
fnp-2615	323	26	h.	h.	PROPN
fnp-2615	323	27	arterial	arterial	NOUN
fnp-2615	323	28	stiffness	stiffness	NOUN
fnp-2615	323	29	due	due	ADP
fnp-2615	323	30	to	to	ADP
fnp-2615	323	31	carotid	carotid	NOUN
fnp-2615	323	32	calcification	calcification	NOUN
fnp-2615	323	33	disrupts	disrupt	VERB
fnp-2615	323	34	cerebral	cerebral	ADJ
fnp-2615	323	35	blood	blood	NOUN
fnp-2615	323	36	flow	flow	NOUN
fnp-2615	323	37	regulation	regulation	NOUN
fnp-2615	323	38	and	and	CCONJ
fnp-2615	323	39	leads	lead	VERB
fnp-2615	323	40	to	to	ADP
fnp-2615	323	41	cognitive	cognitive	ADJ
fnp-2615	323	42	deficits	deficit	NOUN
fnp-2615	323	43	.	.	PUNCT
fnp-2615	324	1	j	j	PROPN
fnp-2615	324	2	am	be	AUX
fnp-2615	324	3	heart	heart	NOUN
fnp-2615	324	4	assoc	assoc	NOUN
fnp-2615	324	5	.	.	PUNCT
fnp-2615	325	1	2019	2019	NUM
fnp-2615	325	2	;	;	PUNCT
fnp-2615	326	1	8(9):e011630	8(9):e011630	NUM
fnp-2615	326	2	.	.	PUNCT
fnp-2615	327	1	doi	doi	NOUN
fnp-2615	327	2	:	:	PUNCT
fnp-2615	327	3	10.1161	10.1161	NUM
fnp-2615	327	4	/	/	SYM
fnp-2615	327	5	jaha.118.011630	jaha.118.011630	PROPN
fnp-2615	327	6	.	.	PUNCT
fnp-2615	328	1	neves	neves	PROPN
fnp-2615	328	2	kb	kb	PROPN
fnp-2615	328	3	,	,	PUNCT
fnp-2615	328	4	harvey	harvey	PROPN
fnp-2615	328	5	ap	ap	PROPN
fnp-2615	328	6	,	,	PUNCT
fnp-2615	328	7	moreton	moreton	PROPN
fnp-2615	328	8	f	f	PROPN
fnp-2615	328	9	,	,	PUNCT
fnp-2615	328	10	montezano	montezano	PROPN
fnp-2615	328	11	ac	ac	PROPN
fnp-2615	328	12	,	,	PUNCT
fnp-2615	328	13	rios	rios	PROPN
fnp-2615	328	14	fj	fj	PROPN
fnp-2615	328	15	,	,	PUNCT
fnp-2615	328	16	alves	alves	PROPN
fnp-2615	328	17	-	-	PUNCT
fnp-2615	328	18	lopes	lopes	PROPN
fnp-2615	328	19	r	r	PROPN
fnp-2615	328	20	,	,	PUNCT
fnp-2615	328	21	nguyen	nguyen	PROPN
fnp-2615	328	22	dinh	dinh	PROPN
fnp-2615	328	23	cat	cat	PROPN
fnp-2615	328	24	a	a	PROPN
fnp-2615	328	25	,	,	PUNCT
fnp-2615	328	26	rocchicciolli	rocchicciolli	PROPN
fnp-2615	328	27	p	p	X
fnp-2615	328	28	,	,	PUNCT
fnp-2615	328	29	delles	delle	VERB
fnp-2615	328	30	c	c	NOUN
fnp-2615	328	31	,	,	PUNCT
fnp-2615	328	32	joutel	joutel	NOUN
fnp-2615	328	33	a	a	PRON
fnp-2615	328	34	,	,	PUNCT
fnp-2615	328	35	muir	muir	PROPN
fnp-2615	328	36	k	k	PROPN
fnp-2615	328	37	,	,	PUNCT
fnp-2615	328	38	touyz	touyz	PROPN
fnp-2615	328	39	rm	rm	PROPN
fnp-2615	328	40	.	.	PUNCT
fnp-2615	329	1	er	er	INTJ
fnp-2615	329	2	stress	stress	NOUN
fnp-2615	329	3	and	and	CCONJ
fnp-2615	329	4	rho	rho	ADJ
fnp-2615	329	5	kinase	kinase	NOUN
fnp-2615	329	6	activation	activation	NOUN
fnp-2615	329	7	underlie	underlie	VERB
fnp-2615	329	8	the	the	DET
fnp-2615	329	9	vasculopathy	vasculopathy	NOUN
fnp-2615	329	10	of	of	ADP
fnp-2615	329	11	cadasil	cadasil	PROPN
fnp-2615	329	12	.	.	PUNCT
fnp-2615	330	1	jci	jci	PROPN
fnp-2615	330	2	insight	insight	PROPN
fnp-2615	330	3	.	.	PUNCT
fnp-2615	331	1	2019	2019	NUM
fnp-2615	331	2	;	;	PUNCT
fnp-2615	331	3	4(23	4(23	NOUN
fnp-2615	331	4	)	)	PUNCT
fnp-2615	331	5	.	.	PUNCT
fnp-2615	332	1	pii	pii	PROPN
fnp-2615	332	2	:	:	PUNCT
fnp-2615	332	3	131344	131344	NUM
fnp-2615	332	4	.	.	PUNCT
fnp-2615	333	1	doi	doi	NOUN
fnp-2615	333	2	:	:	PUNCT
fnp-2615	333	3	10.1172	10.1172	NUM
fnp-2615	333	4	/	/	SYM
fnp-2615	333	5	jci.insight.131344	jci.insight.131344	PROPN
fnp-2615	333	6	.	.	PUNCT
fnp-2615	334	1	nikolakopoulou	nikolakopoulou	PROPN
fnp-2615	334	2	am	am	PROPN
fnp-2615	334	3	,	,	PUNCT
fnp-2615	334	4	montagne	montagne	PROPN
fnp-2615	334	5	a	a	NOUN
fnp-2615	334	6	,	,	PUNCT
fnp-2615	334	7	kisler	kisler	PROPN
fnp-2615	334	8	k	k	PROPN
fnp-2615	334	9	,	,	PUNCT
fnp-2615	334	10	dai	dai	PROPN
fnp-2615	334	11	z	z	PROPN
fnp-2615	334	12	,	,	PUNCT
fnp-2615	334	13	wang	wang	PROPN
fnp-2615	334	14	y	y	PROPN
fnp-2615	334	15	,	,	PUNCT
fnp-2615	334	16	huuskonen	huuskonen	PROPN
fnp-2615	334	17	mt	mt	PROPN
fnp-2615	334	18	,	,	PUNCT
fnp-2615	334	19	sagare	sagare	PROPN
fnp-2615	334	20	ap	ap	PROPN
fnp-2615	334	21	,	,	PUNCT
fnp-2615	334	22	lazic	lazic	PROPN
fnp-2615	334	23	d	d	PROPN
fnp-2615	334	24	,	,	PUNCT
fnp-2615	334	25	sweeney	sweeney	PROPN
fnp-2615	334	26	md	md	PROPN
fnp-2615	334	27	,	,	PUNCT
fnp-2615	334	28	kong	kong	PROPN
fnp-2615	334	29	p	p	X
fnp-2615	334	30	,	,	PUNCT
fnp-2615	334	31	wang	wang	PROPN
fnp-2615	334	32	m	m	PROPN
fnp-2615	334	33	,	,	PUNCT
fnp-2615	334	34	owens	owens	PROPN
fnp-2615	334	35	nc	nc	PROPN
fnp-2615	334	36	,	,	PUNCT
fnp-2615	334	37	lawson	lawson	PROPN
fnp-2615	334	38	ej	ej	PROPN
fnp-2615	334	39	,	,	PUNCT
fnp-2615	334	40	xie	xie	PROPN
fnp-2615	335	1	x	x	PROPN
fnp-2615	335	2	,	,	PUNCT
fnp-2615	335	3	zhao	zhao	PROPN
fnp-2615	335	4	z	z	PROPN
fnp-2615	335	5	,	,	PUNCT
fnp-2615	335	6	zlokovic	zlokovic	PROPN
fnp-2615	335	7	bv	bv	PROPN
fnp-2615	335	8	.	.	PROPN
fnp-2615	335	9	pericyte	pericyte	NOUN
fnp-2615	335	10	loss	loss	NOUN
fnp-2615	335	11	leads	lead	VERB
fnp-2615	335	12	to	to	ADP
fnp-2615	335	13	circulatory	circulatory	ADJ
fnp-2615	335	14	failure	failure	NOUN
fnp-2615	335	15	and	and	CCONJ
fnp-2615	335	16	pleiotrophin	pleiotrophin	NOUN
fnp-2615	335	17	depletion	depletion	NOUN
fnp-2615	335	18	causing	cause	VERB
fnp-2615	335	19	neuron	neuron	NOUN
fnp-2615	335	20	loss	loss	NOUN
fnp-2615	335	21	.	.	PUNCT
fnp-2615	336	1	nat	nat	PROPN
fnp-2615	336	2	neurosci	neurosci	PROPN
fnp-2615	336	3	.	.	PUNCT
fnp-2615	337	1	2019	2019	NUM
fnp-2615	337	2	;	;	PUNCT
fnp-2615	338	1	22(7):1089	22(7):1089	NUM
fnp-2615	338	2	-	-	SYM
fnp-2615	338	3	1098	1098	NUM
fnp-2615	338	4	.	.	PUNCT
fnp-2615	339	1	doi	doi	NOUN
fnp-2615	339	2	:	:	PUNCT
fnp-2615	339	3	10.1038	10.1038	NUM
fnp-2615	339	4	/	/	SYM
fnp-2615	339	5	s41593	s41593	PROPN
fnp-2615	339	6	-	-	PUNCT
fnp-2615	339	7	019	019	NUM
fnp-2615	339	8	-	-	PUNCT
fnp-2615	339	9	0434	0434	NUM
fnp-2615	339	10	-	-	PUNCT
fnp-2615	339	11	z.	z.	PROPN
fnp-2615	339	12	reijmer	reijmer	PROPN
fnp-2615	339	13	yd	yd	PROPN
fnp-2615	339	14	,	,	PUNCT
fnp-2615	339	15	fotiadis	fotiadis	NOUN
fnp-2615	339	16	p	p	X
fnp-2615	339	17	,	,	PUNCT
fnp-2615	339	18	martinez	martinez	PROPN
fnp-2615	339	19	-	-	PROPN
fnp-2615	339	20	ramirez	ramirez	PROPN
fnp-2615	339	21	s	s	PART
fnp-2615	339	22	,	,	PUNCT
fnp-2615	339	23	salat	salat	ADJ
fnp-2615	339	24	dh	dh	NOUN
fnp-2615	339	25	,	,	PUNCT
fnp-2615	339	26	schultz	schultz	PROPN
fnp-2615	339	27	a	a	PRON
fnp-2615	339	28	,	,	PUNCT
fnp-2615	339	29	shoamanesh	shoamanesh	NOUN
fnp-2615	339	30	a	a	NOUN
fnp-2615	339	31	,	,	PUNCT
fnp-2615	339	32	ayres	ayres	PROPN
fnp-2615	339	33	am	be	AUX
fnp-2615	339	34	,	,	PUNCT
fnp-2615	339	35	vashkevich	vashkevich	VERB
fnp-2615	339	36	a	a	PRON
fnp-2615	339	37	,	,	PUNCT
fnp-2615	339	38	rosas	rosas	PROPN
fnp-2615	339	39	d	d	PROPN
fnp-2615	339	40	,	,	PUNCT
fnp-2615	339	41	schwab	schwab	PROPN
fnp-2615	339	42	k	k	PROPN
fnp-2615	339	43	,	,	PUNCT
fnp-2615	339	44	leemans	leeman	VERB
fnp-2615	339	45	a	a	DET
fnp-2615	339	46	,	,	PUNCT
fnp-2615	339	47	biessels	biessel	NOUN
fnp-2615	339	48	gj	gj	NOUN
fnp-2615	339	49	,	,	PUNCT
fnp-2615	339	50	rosand	rosand	PROPN
fnp-2615	339	51	j	j	PROPN
fnp-2615	339	52	,	,	PUNCT
fnp-2615	339	53	johnson	johnson	PROPN
fnp-2615	339	54	ka	ka	PROPN
fnp-2615	339	55	,	,	PUNCT
fnp-2615	339	56	viswanathan	viswanathan	PROPN
fnp-2615	339	57	a	a	PRON
fnp-2615	339	58	,	,	PUNCT
fnp-2615	339	59	gurol	gurol	VERB
fnp-2615	339	60	me	i	PRON
fnp-2615	339	61	,	,	PUNCT
fnp-2615	339	62	greenberg	greenberg	PROPN
fnp-2615	339	63	sm	sm	PROPN
fnp-2615	339	64	.	.	PROPN
fnp-2615	339	65	structural	structural	ADJ
fnp-2615	339	66	network	network	NOUN
fnp-2615	339	67	alterations	alteration	NOUN
fnp-2615	339	68	and	and	CCONJ
fnp-2615	339	69	neurological	neurological	ADJ
fnp-2615	339	70	dysfunction	dysfunction	NOUN
fnp-2615	339	71	in	in	ADP
fnp-2615	339	72	cerebral	cerebral	ADJ
fnp-2615	339	73	amyloid	amyloid	NOUN
fnp-2615	339	74	angiopathy	angiopathy	NOUN
fnp-2615	339	75	.	.	PUNCT
fnp-2615	340	1	brain	brain	NOUN
fnp-2615	340	2	.	.	PUNCT
fnp-2615	341	1	2015;138(pt	2015;138(pt	NUM
fnp-2615	341	2	1):179	1):179	NUM
fnp-2615	341	3	-	-	SYM
fnp-2615	341	4	88	88	NUM
fnp-2615	341	5	.	.	PUNCT
fnp-2615	342	1	doi	doi	NOUN
fnp-2615	342	2	:	:	PUNCT
fnp-2615	342	3	10.1093	10.1093	NUM
fnp-2615	342	4	/	/	SYM
fnp-2615	342	5	brain	brain	NOUN
fnp-2615	342	6	/	/	SYM
fnp-2615	342	7	awu316	awu316	PROPN
fnp-2615	342	8	.	.	PUNCT
fnp-2615	342	9	tan	tan	PROPN
fnp-2615	343	1	c	c	PROPN
fnp-2615	343	2	,	,	PUNCT
fnp-2615	343	3	lu	lu	PROPN
fnp-2615	343	4	nn	nn	PROPN
fnp-2615	343	5	,	,	PUNCT
fnp-2615	343	6	wang	wang	PROPN
fnp-2615	343	7	ck	ck	PROPN
fnp-2615	343	8	,	,	PUNCT
fnp-2615	343	9	chen	chen	PROPN
fnp-2615	343	10	dy	dy	PROPN
fnp-2615	343	11	,	,	PUNCT
fnp-2615	343	12	sun	sun	PROPN
fnp-2615	343	13	nh	nh	PROPN
fnp-2615	343	14	,	,	PUNCT
fnp-2615	343	15	lyu	lyu	VERB
fnp-2615	343	16	h	h	PROPN
fnp-2615	343	17	,	,	PUNCT
fnp-2615	343	18	körbelin	körbelin	PROPN
fnp-2615	343	19	j	j	PROPN
fnp-2615	343	20	,	,	PUNCT
fnp-2615	343	21	shi	shi	PROPN
fnp-2615	343	22	wx	wx	PROPN
fnp-2615	343	23	,	,	PUNCT
fnp-2615	343	24	fukunaga	fukunaga	PROPN
fnp-2615	343	25	k	k	PROPN
fnp-2615	343	26	,	,	PUNCT
fnp-2615	343	27	lu	lu	PROPN
fnp-2615	343	28	ym	ym	PROPN
fnp-2615	343	29	,	,	PUNCT
fnp-2615	343	30	han	han	PROPN
fnp-2615	343	31	f.	f.	PROPN
fnp-2615	343	32	endothelium	endothelium	PROPN
fnp-2615	343	33	-	-	PUNCT
fnp-2615	343	34	derived	derive	VERB
fnp-2615	343	35	semaphorin	semaphorin	NOUN
fnp-2615	343	36	3	3	NUM
fnp-2615	343	37	g	g	NOUN
fnp-2615	343	38	regulates	regulate	VERB
fnp-2615	343	39	hippocampal	hippocampal	ADJ
fnp-2615	343	40	synaptic	synaptic	ADJ
fnp-2615	343	41	structure	structure	NOUN
fnp-2615	343	42	and	and	CCONJ
fnp-2615	343	43	plasticity	plasticity	NOUN
fnp-2615	343	44	via	via	ADP
fnp-2615	343	45	neuropilin-2	neuropilin-2	NUM
fnp-2615	343	46	/	/	SYM
fnp-2615	343	47	plexina4	plexina4	NOUN
fnp-2615	343	48	.	.	PUNCT
fnp-2615	343	49	neuron	neuron	PROPN
fnp-2615	343	50	.	.	PUNCT
fnp-2615	344	1	2019	2019	NUM
fnp-2615	344	2	;	;	PUNCT
fnp-2615	344	3	101(5):920	101(5):920	NUM
fnp-2615	344	4	-	-	SYM
fnp-2615	344	5	937.e13	937.e13	NUM
fnp-2615	344	6	.	.	PUNCT
fnp-2615	345	1	doi	doi	NOUN
fnp-2615	345	2	:	:	PUNCT
fnp-2615	345	3	10.1016	10.1016	NUM
fnp-2615	345	4	/	/	SYM
fnp-2615	345	5	j.neuron.2018.12.036	j.neuron.2018.12.036	PROPN
fnp-2615	345	6	.	.	PUNCT
fnp-2615	346	1	traylor	traylor	PROPN
fnp-2615	346	2	m	m	PROPN
fnp-2615	346	3	,	,	PUNCT
fnp-2615	346	4	tozer	tozer	PROPN
fnp-2615	346	5	dj	dj	PROPN
fnp-2615	346	6	,	,	PUNCT
fnp-2615	346	7	croall	croall	PROPN
fnp-2615	346	8	i	i	PROPN
fnp-2615	346	9	d	d	PROPN
fnp-2615	346	10	,	,	PUNCT
fnp-2615	346	11	lisiecka	lisiecka	NOUN
fnp-2615	346	12	-	-	PUNCT
fnp-2615	346	13	ford	ford	PROPN
fnp-2615	346	14	dm	dm	PROPN
fnp-2615	346	15	,	,	PUNCT
fnp-2615	346	16	olorunda	olorunda	ADJ
fnp-2615	346	17	ao	ao	PROPN
fnp-2615	346	18	,	,	PUNCT
fnp-2615	346	19	boncoraglio	boncoraglio	NOUN
fnp-2615	346	20	g	g	PROPN
fnp-2615	346	21	,	,	PUNCT
fnp-2615	346	22	dichgans	dichgans	PROPN
fnp-2615	346	23	m	m	PROPN
fnp-2615	346	24	,	,	PUNCT
fnp-2615	346	25	lemmens	lemmen	VERB
fnp-2615	346	26	r	r	NOUN
fnp-2615	346	27	,	,	PUNCT
fnp-2615	346	28	rosand	rosand	PROPN
fnp-2615	346	29	j	j	PROPN
fnp-2615	346	30	,	,	PUNCT
fnp-2615	346	31	rost	rost	PROPN
fnp-2615	346	32	ns	ns	PROPN
fnp-2615	346	33	,	,	PUNCT
fnp-2615	346	34	rothwell	rothwell	PROPN
fnp-2615	346	35	pm	pm	PROPN
fnp-2615	346	36	,	,	PUNCT
fnp-2615	346	37	sudlow	sudlow	PROPN
fnp-2615	346	38	clm	clm	PROPN
fnp-2615	346	39	,	,	PUNCT
fnp-2615	346	40	thijs	thijs	PROPN
fnp-2615	346	41	v	v	NOUN
fnp-2615	346	42	,	,	PUNCT
fnp-2615	346	43	rutten	rutten	PROPN
fnp-2615	346	44	-	-	PUNCT
fnp-2615	346	45	jacobs	jacobs	PROPN
fnp-2615	346	46	l	l	PROPN
fnp-2615	346	47	,	,	PUNCT
fnp-2615	346	48	markus	markus	PROPN
fnp-2615	346	49	hs	hs	PROPN
fnp-2615	346	50	;	;	PUNCT
fnp-2615	346	51	international	international	ADJ
fnp-2615	346	52	stroke	stroke	NOUN
fnp-2615	346	53	genetics	genetics	PROPN
fnp-2615	346	54	consortium	consortium	NOUN
fnp-2615	346	55	.	.	PUNCT
fnp-2615	347	1	genetic	genetic	ADJ
fnp-2615	347	2	variation	variation	NOUN
fnp-2615	347	3	in	in	ADP
fnp-2615	347	4	plekhg1	plekhg1	NOUN
fnp-2615	347	5	is	be	AUX
fnp-2615	347	6	associated	associate	VERB
fnp-2615	347	7	with	with	ADP
fnp-2615	347	8	white	white	ADJ
fnp-2615	347	9	matter	matter	NOUN
fnp-2615	347	10	hyperintensities	hyperintensitie	NOUN
fnp-2615	347	11	(	(	PUNCT
fnp-2615	347	12	n	n	NOUN
fnp-2615	347	13	=	=	SYM
fnp-2615	347	14	11,226	11,226	NUM
fnp-2615	347	15	)	)	PUNCT
fnp-2615	347	16	.	.	PUNCT
fnp-2615	348	1	neurology	neurology	NOUN
fnp-2615	348	2	.	.	PUNCT
fnp-2615	349	1	2019	2019	NUM
fnp-2615	349	2	;	;	PUNCT
fnp-2615	350	1	92(8):e749	92(8):e749	X
fnp-2615	350	2	-	-	PUNCT
fnp-2615	350	3	e757	e757	PROPN
fnp-2615	350	4	.	.	PUNCT
fnp-2615	351	1	doi	doi	NOUN
fnp-2615	351	2	:	:	PUNCT
fnp-2615	351	3	10.1212	10.1212	NUM
fnp-2615	351	4	/	/	SYM
fnp-2615	351	5	wnl.0000000000006952	wnl.0000000000006952	NOUN
fnp-2615	351	6	.	.	PUNCT
fnp-2615	352	1	van	van	PROPN
fnp-2615	352	2	dijk	dijk	PROPN
fnp-2615	352	3	bj	bj	PROPN
fnp-2615	352	4	,	,	PUNCT
fnp-2615	352	5	meijers	meijers	PROPN
fnp-2615	352	6	jcm	jcm	PROPN
fnp-2615	352	7	,	,	PUNCT
fnp-2615	352	8	kloek	kloek	VERB
fnp-2615	352	9	at	at	ADP
fnp-2615	352	10	,	,	PUNCT
fnp-2615	352	11	knaup	knaup	PROPN
fnp-2615	352	12	vl	vl	PROPN
fnp-2615	352	13	,	,	PUNCT
fnp-2615	352	14	rinkel	rinkel	NOUN
fnp-2615	352	15	gje	gje	NOUN
fnp-2615	352	16	,	,	PUNCT
fnp-2615	352	17	morgan	morgan	PROPN
fnp-2615	352	18	bp	bp	PROPN
fnp-2615	352	19	,	,	PUNCT
fnp-2615	352	20	van	van	PROPN
fnp-2615	352	21	der	der	PROPN
fnp-2615	352	22	kamp	kamp	PROPN
fnp-2615	352	23	mj	mj	PROPN
fnp-2615	352	24	,	,	PUNCT
fnp-2615	352	25	osuka	osuka	PROPN
fnp-2615	352	26	k	k	PROPN
fnp-2615	352	27	,	,	PUNCT
fnp-2615	352	28	aronica	aronica	PROPN
fnp-2615	352	29	e	e	PROPN
fnp-2615	352	30	,	,	PUNCT
fnp-2615	352	31	ruigrok	ruigrok	PROPN
fnp-2615	352	32	ym	ym	PROPN
fnp-2615	352	33	,	,	PUNCT
fnp-2615	352	34	van	van	PROPN
fnp-2615	352	35	de	de	PROPN
fnp-2615	352	36	beek	beek	PROPN
fnp-2615	352	37	d	d	PROPN
fnp-2615	352	38	,	,	PUNCT
fnp-2615	352	39	brouwer	brouwer	PROPN
fnp-2615	352	40	m	m	PROPN
fnp-2615	352	41	,	,	PUNCT
fnp-2615	352	42	pekna	pekna	PROPN
fnp-2615	352	43	m	m	PROPN
fnp-2615	352	44	,	,	PUNCT
fnp-2615	352	45	hol	hol	VERB
fnp-2615	352	46	em	em	PRON
fnp-2615	352	47	,	,	PUNCT
fnp-2615	352	48	vergouwen	vergouwen	PROPN
fnp-2615	352	49	mdi	mdi	PROPN
fnp-2615	352	50	.	.	PROPN
fnp-2615	352	51	complement	complement	PROPN
fnp-2615	352	52	c5	c5	PROPN
fnp-2615	352	53	contributes	contribute	VERB
fnp-2615	352	54	to	to	ADP
fnp-2615	352	55	brain	brain	NOUN
fnp-2615	352	56	injury	injury	NOUN
fnp-2615	352	57	after	after	SCONJ
fnp-2615	352	58	subarachnoid	subarachnoid	VERB
fnp-2615	352	59	hemorrhage	hemorrhage	NOUN
fnp-2615	352	60	.	.	PUNCT
fnp-2615	353	1	transl	transl	PROPN
fnp-2615	353	2	stroke	stroke	NOUN
fnp-2615	353	3	res	re	NOUN
fnp-2615	353	4	.	.	PROPN
fnp-2615	354	1	2019	2019	NUM
fnp-2615	354	2	dec	dec	PROPN
fnp-2615	354	3	6	6	NUM
fnp-2615	354	4	.	.	PUNCT
fnp-2615	354	5	doi	doi	NOUN
fnp-2615	354	6	:	:	PUNCT
fnp-2615	354	7	10.1007	10.1007	NUM
fnp-2615	354	8	/	/	SYM
fnp-2615	354	9	s12975	s12975	NOUN
fnp-2615	354	10	-	-	PUNCT
fnp-2615	354	11	019	019	NUM
fnp-2615	354	12	-	-	PUNCT
fnp-2615	354	13	00757	00757	NUM
fnp-2615	354	14	-	-	SYM
fnp-2615	354	15	0	0	NUM
fnp-2615	354	16	.	.	PUNCT
fnp-2615	355	1	van	van	PROPN
fnp-2615	355	2	veluw	veluw	NOUN
fnp-2615	355	3	sj	sj	PROPN
fnp-2615	355	4	,	,	PUNCT
fnp-2615	355	5	reijmer	reijmer	PROPN
fnp-2615	355	6	yd	yd	PROPN
fnp-2615	355	7	,	,	PUNCT
fnp-2615	355	8	van	van	PROPN
fnp-2615	355	9	der	der	PROPN
fnp-2615	355	10	kouwe	kouwe	PROPN
fnp-2615	355	11	aj	aj	PROPN
fnp-2615	355	12	,	,	PUNCT
fnp-2615	355	13	charidimou	charidimou	ADV
fnp-2615	355	14	a	a	PRON
fnp-2615	355	15	,	,	PUNCT
fnp-2615	355	16	riley	riley	PROPN
fnp-2615	355	17	ga	ga	PROPN
fnp-2615	355	18	,	,	PUNCT
fnp-2615	355	19	leemans	leeman	VERB
fnp-2615	355	20	a	a	DET
fnp-2615	355	21	,	,	PUNCT
fnp-2615	355	22	bacskai	bacskai	ADJ
fnp-2615	355	23	bj	bj	NOUN
fnp-2615	355	24	,	,	PUNCT
fnp-2615	355	25	frosch	frosch	PROPN
fnp-2615	355	26	mp	mp	PROPN
fnp-2615	355	27	,	,	PUNCT
fnp-2615	355	28	viswanathan	viswanathan	PROPN
fnp-2615	355	29	a	a	PROPN
fnp-2615	355	30	,	,	PUNCT
fnp-2615	355	31	greenberg	greenberg	PROPN
fnp-2615	355	32	sm	sm	PROPN
fnp-2615	355	33	.	.	PROPN
fnp-2615	355	34	histopathology	histopathology	PROPN
fnp-2615	355	35	of	of	ADP
fnp-2615	355	36	diffusion	diffusion	NOUN
fnp-2615	355	37	imaging	imaging	NOUN
fnp-2615	355	38	abnormalities	abnormality	NOUN
fnp-2615	355	39	in	in	ADP
fnp-2615	355	40	cerebral	cerebral	ADJ
fnp-2615	355	41	amyloid	amyloid	NOUN
fnp-2615	355	42	angiopathy	angiopathy	NOUN
fnp-2615	355	43	.	.	PUNCT
fnp-2615	356	1	neurology	neurology	NOUN
fnp-2615	356	2	.	.	PUNCT
fnp-2615	357	1	2019b	2019b	NOUN
fnp-2615	357	2	;	;	PUNCT
fnp-2615	358	1	92(9):e933	92(9):e933	NUM
fnp-2615	358	2	-	-	SYM
fnp-2615	358	3	e943	e943	PROPN
fnp-2615	358	4	.	.	PUNCT
fnp-2615	359	1	doi	doi	PROPN
fnp-2615	359	2	:	:	PUNCT
fnp-2615	359	3	10.1212	10.1212	NUM
fnp-2615	359	4	/	/	SYM
fnp-2615	359	5	wnl.0000000000007005	wnl.0000000000007005	NOUN
fnp-2615	359	6	.	.	PUNCT
fnp-2615	360	1	van	van	PROPN
fnp-2615	360	2	veluw	veluw	NOUN
fnp-2615	360	3	sj	sj	PROPN
fnp-2615	360	4	,	,	PUNCT
fnp-2615	360	5	scherlek	scherlek	ADJ
fnp-2615	360	6	aa	aa	NOUN
fnp-2615	360	7	,	,	PUNCT
fnp-2615	360	8	freeze	freeze	VERB
fnp-2615	360	9	wm	wm	PROPN
fnp-2615	360	10	,	,	PUNCT
fnp-2615	360	11	ter	ter	NOUN
fnp-2615	360	12	telgte	telgte	NOUN
fnp-2615	360	13	a	a	PRON
fnp-2615	360	14	,	,	PUNCT
fnp-2615	360	15	van	van	PROPN
fnp-2615	360	16	der	der	PROPN
fnp-2615	360	17	kouwe	kouwe	PROPN
fnp-2615	360	18	aj	aj	PROPN
fnp-2615	360	19	,	,	PUNCT
fnp-2615	360	20	bacskai	bacskai	ADJ
fnp-2615	360	21	bj	bj	NOUN
fnp-2615	360	22	,	,	PUNCT
fnp-2615	360	23	frosch	frosch	PROPN
fnp-2615	360	24	mp	mp	PROPN
fnp-2615	360	25	,	,	PUNCT
fnp-2615	360	26	greenberg	greenberg	PROPN
fnp-2615	360	27	sm	sm	PROPN
fnp-2615	360	28	.	.	PUNCT
fnp-2615	361	1	different	different	ADJ
fnp-2615	361	2	microvascular	microvascular	NOUN
fnp-2615	361	3	alterations	alteration	NOUN
fnp-2615	361	4	underlie	underlie	ADJ
fnp-2615	361	5	microbleeds	microbleed	NOUN
fnp-2615	361	6	and	and	CCONJ
fnp-2615	361	7	microinfarcts	microinfarct	NOUN
fnp-2615	361	8	.	.	PUNCT
fnp-2615	362	1	ann	ann	PROPN
fnp-2615	362	2	neurol	neurol	PROPN
fnp-2615	362	3	.	.	PUNCT
fnp-2615	363	1	2019a	2019a	NUM
fnp-2615	363	2	;	;	PUNCT
fnp-2615	364	1	86(2):279	86(2):279	NOUN
fnp-2615	364	2	-	-	SYM
fnp-2615	364	3	292	292	NUM
fnp-2615	364	4	.	.	PUNCT
fnp-2615	365	1	doi	doi	NOUN
fnp-2615	365	2	:	:	PUNCT
fnp-2615	365	3	10.1002	10.1002	NUM
fnp-2615	365	4	/	/	SYM
fnp-2615	365	5	ana.25512	ana.25512	PROPN
fnp-2615	365	6	.	.	PUNCT
fnp-2615	366	1	yao	yao	PROPN
fnp-2615	366	2	j	j	PROPN
fnp-2615	366	3	,	,	PUNCT
fnp-2615	366	4	wu	wu	PROPN
fnp-2615	366	5	x	x	PROPN
fnp-2615	366	6	,	,	PUNCT
fnp-2615	366	7	zhang	zhang	PROPN
fnp-2615	366	8	d	d	PROPN
fnp-2615	366	9	,	,	PUNCT
fnp-2615	366	10	wang	wang	PROPN
fnp-2615	366	11	l	l	PROPN
fnp-2615	366	12	,	,	PUNCT
fnp-2615	366	13	zhang	zhang	PROPN
fnp-2615	366	14	l	l	PROPN
fnp-2615	366	15	,	,	PUNCT
fnp-2615	366	16	reynolds	reynolds	PROPN
fnp-2615	366	17	ex	ex	PROPN
fnp-2615	366	18	,	,	PUNCT
fnp-2615	366	19	hernandez	hernandez	PROPN
fnp-2615	366	20	c	c	PROPN
fnp-2615	366	21	,	,	PUNCT
fnp-2615	366	22	boström	boström	ADV
fnp-2615	366	23	ki	ki	PROPN
fnp-2615	366	24	,	,	PUNCT
fnp-2615	366	25	yao	yao	PROPN
fnp-2615	366	26	y.	y.	PROPN
fnp-2615	366	27	elevated	elevate	VERB
fnp-2615	366	28	endothelial	endothelial	ADJ
fnp-2615	366	29	sox2	sox2	NOUN
fnp-2615	366	30	causes	cause	VERB
fnp-2615	366	31	lumen	luman	NOUN
fnp-2615	366	32	disruption	disruption	NOUN
fnp-2615	366	33	and	and	CCONJ
fnp-2615	366	34	cerebral	cerebral	ADJ
fnp-2615	366	35	arteriovenous	arteriovenous	ADJ
fnp-2615	366	36	malformations	malformation	NOUN
fnp-2615	366	37	.	.	PUNCT
fnp-2615	367	1	j	j	PROPN
fnp-2615	367	2	clin	clin	PROPN
fnp-2615	367	3	invest	invest	PROPN
fnp-2615	367	4	.	.	PUNCT
fnp-2615	368	1	2019	2019	NUM
fnp-2615	368	2	;	;	PUNCT
fnp-2615	368	3	129(8):3121	129(8):3121	NUM
fnp-2615	368	4	-	-	SYM
fnp-2615	368	5	3133	3133	NUM
fnp-2615	368	6	.	.	PUNCT
fnp-2615	369	1	doi	doi	NOUN
fnp-2615	369	2	:	:	PUNCT
fnp-2615	369	3	10.1172	10.1172	NUM
fnp-2615	369	4	/	/	SYM
fnp-2615	369	5	jci125965	jci125965	NOUN
fnp-2615	369	6	.	.	PUNCT
fnp-2615	370	1	yao	yao	PROPN
fnp-2615	370	2	y	y	PROPN
fnp-2615	370	3	,	,	PUNCT
fnp-2615	370	4	jumabay	jumabay	NOUN
fnp-2615	370	5	m	m	PROPN
fnp-2615	370	6	,	,	PUNCT
fnp-2615	370	7	ly	ly	ADP
fnp-2615	370	8	a	a	PRON
fnp-2615	370	9	,	,	PUNCT
fnp-2615	370	10	radparvar	radparvar	NOUN
fnp-2615	370	11	m	m	PROPN
fnp-2615	370	12	,	,	PUNCT
fnp-2615	370	13	cubberly	cubberly	ADV
fnp-2615	370	14	mr	mr	PROPN
fnp-2615	370	15	,	,	PUNCT
fnp-2615	370	16	boström	boström	ADV
fnp-2615	371	1	ki	ki	PROPN
fnp-2615	371	2	.	.	PUNCT
fnp-2615	372	1	a	a	DET
fnp-2615	372	2	role	role	NOUN
fnp-2615	372	3	for	for	ADP
fnp-2615	372	4	the	the	DET
fnp-2615	372	5	endothelium	endothelium	NOUN
fnp-2615	372	6	in	in	ADP
fnp-2615	372	7	vascular	vascular	ADJ
fnp-2615	372	8	calcification	calcification	NOUN
fnp-2615	372	9	.	.	PUNCT
fnp-2615	373	1	circ	circ	PROPN
fnp-2615	373	2	res	re	NOUN
fnp-2615	373	3	.	.	PUNCT
fnp-2615	373	4	2013	2013	NUM
fnp-2615	373	5	;	;	PUNCT
fnp-2615	373	6	113(5):495	113(5):495	NUM
fnp-2615	373	7	-	-	PUNCT
fnp-2615	373	8	504	504	NUM
fnp-2615	373	9	.	.	PUNCT
fnp-2615	374	1	doi	doi	NOUN
fnp-2615	374	2	:	:	PUNCT
fnp-2615	374	3	10.1161	10.1161	NUM
fnp-2615	374	4	/	/	SYM
fnp-2615	374	5	circresaha.113.301792	circresaha.113.301792	NOUN
fnp-2615	374	6	.	.	PUNCT
fnp-2615	374	7	yin	yin	PROPN
fnp-2615	374	8	c	c	PROPN
fnp-2615	374	9	,	,	PUNCT
fnp-2615	374	10	ackermann	ackermann	PROPN
fnp-2615	374	11	s	s	PROPN
fnp-2615	374	12	,	,	PUNCT
fnp-2615	374	13	ma	ma	PROPN
fnp-2615	374	14	z	z	PROPN
fnp-2615	374	15	,	,	PUNCT
fnp-2615	374	16	mohanta	mohanta	PROPN
fnp-2615	374	17	sk	sk	PROPN
fnp-2615	374	18	,	,	PUNCT
fnp-2615	374	19	zhang	zhang	PROPN
fnp-2615	374	20	c	c	PROPN
fnp-2615	374	21	,	,	PUNCT
fnp-2615	374	22	li	li	PROPN
fnp-2615	374	23	y	y	PROPN
fnp-2615	374	24	,	,	PUNCT
fnp-2615	374	25	nietzsche	nietzsche	PROPN
fnp-2615	374	26	s	s	PROPN
fnp-2615	374	27	,	,	PUNCT
fnp-2615	374	28	westermann	westermann	PROPN
fnp-2615	374	29	m	m	PROPN
fnp-2615	374	30	,	,	PUNCT
fnp-2615	374	31	peng	peng	PROPN
fnp-2615	374	32	l	l	PROPN
fnp-2615	374	33	,	,	PUNCT
fnp-2615	374	34	hu	hu	PROPN
fnp-2615	375	1	d	d	PROPN
fnp-2615	375	2	,	,	PUNCT
fnp-2615	375	3	bontha	bontha	PROPN
fnp-2615	375	4	sv	sv	PROPN
fnp-2615	375	5	,	,	PUNCT
fnp-2615	375	6	srikakulapu	srikakulapu	PROPN
fnp-2615	375	7	p	p	NOUN
fnp-2615	375	8	,	,	PUNCT
fnp-2615	375	9	beer	beer	NOUN
fnp-2615	375	10	m	m	PROPN
fnp-2615	375	11	,	,	PUNCT
fnp-2615	375	12	megens	megen	NOUN
fnp-2615	375	13	rta	rta	PROPN
fnp-2615	375	14	,	,	PUNCT
fnp-2615	375	15	steffens	steffen	VERB
fnp-2615	375	16	s	s	PART
fnp-2615	375	17	,	,	PUNCT
fnp-2615	375	18	hildner	hildner	ADJ
fnp-2615	375	19	m	m	PROPN
fnp-2615	375	20	,	,	PUNCT
fnp-2615	375	21	halder	halder	PROPN
fnp-2615	375	22	ld	ld	PROPN
fnp-2615	375	23	,	,	PUNCT
fnp-2615	375	24	eckstein	eckstein	PROPN
fnp-2615	375	25	hh	hh	PROPN
fnp-2615	375	26	,	,	PUNCT
fnp-2615	375	27	pelisek	pelisek	VERB
fnp-2615	375	28	j	j	PROPN
fnp-2615	375	29	,	,	PUNCT
fnp-2615	375	30	herms	herms	PROPN
fnp-2615	375	31	j	j	PROPN
fnp-2615	375	32	,	,	PUNCT
fnp-2615	375	33	roeber	roeber	PROPN
fnp-2615	375	34	s	s	PROPN
fnp-2615	375	35	,	,	PUNCT
fnp-2615	375	36	arzberger	arzberger	PROPN
fnp-2615	375	37	t	t	PROPN
fnp-2615	375	38	,	,	PUNCT
fnp-2615	375	39	borodovsky	borodovsky	NOUN
fnp-2615	375	40	a	a	PRON
fnp-2615	375	41	,	,	PUNCT
fnp-2615	375	42	habenicht	habenicht	PROPN
fnp-2615	375	43	l	l	NOUN
fnp-2615	375	44	,	,	PUNCT
fnp-2615	375	45	binder	binder	NOUN
fnp-2615	375	46	cj	cj	PROPN
fnp-2615	375	47	,	,	PUNCT
fnp-2615	375	48	weber	weber	PROPN
fnp-2615	375	49	c	c	PROPN
fnp-2615	375	50	,	,	PUNCT
fnp-2615	375	51	zipfel	zipfel	NOUN
fnp-2615	375	52	pf	pf	PROPN
fnp-2615	375	53	,	,	PUNCT
fnp-2615	375	54	skerka	skerka	PROPN
fnp-2615	375	55	c	c	NOUN
fnp-2615	375	56	,	,	PUNCT
fnp-2615	375	57	habenicht	habenicht	PROPN
fnp-2615	375	58	ajr	ajr	PROPN
fnp-2615	375	59	.	.	PUNCT
fnp-2615	376	1	apoe	apoe	PROPN
fnp-2615	376	2	attenuates	attenuate	VERB
fnp-2615	376	3	unresolvable	unresolvable	ADJ
fnp-2615	376	4	inflammation	inflammation	NOUN
fnp-2615	376	5	by	by	ADP
fnp-2615	376	6	complex	complex	ADJ
fnp-2615	376	7	formation	formation	NOUN
fnp-2615	376	8	with	with	ADP
fnp-2615	376	9	activated	activate	VERB
fnp-2615	376	10	c1q	c1q	NOUN
fnp-2615	376	11	.	.	PUNCT
fnp-2615	377	1	nat	nat	PROPN
fnp-2615	377	2	med	me	VERB
fnp-2615	377	3	.	.	PUNCT
fnp-2615	378	1	2019;25(3):496	2019;25(3):496	NUM
fnp-2615	378	2	-	-	SYM
fnp-2615	378	3	506	506	NUM
fnp-2615	378	4	.	.	PUNCT
fnp-2615	379	1	doi	doi	NOUN
fnp-2615	379	2	:	:	PUNCT
fnp-2615	379	3	10.1038	10.1038	NUM
fnp-2615	379	4	/	/	SYM
fnp-2615	379	5	s41591	s41591	VERB
fnp-2615	379	6	-	-	PUNCT
fnp-2615	379	7	018	018	NUM
fnp-2615	379	8	-	-	PUNCT
fnp-2615	379	9	0336	0336	NUM
fnp-2615	379	10	-	-	PUNCT
fnp-2615	379	11	8	8	NUM
fnp-2615	379	12	.	.	PUNCT
fnp-2615	380	1	zarb	zarb	PROPN
fnp-2615	380	2	y	y	PROPN
fnp-2615	380	3	,	,	PUNCT
fnp-2615	380	4	weber	weber	PROPN
fnp-2615	380	5	-	-	PUNCT
fnp-2615	380	6	stadlbauer	stadlbauer	NOUN
fnp-2615	380	7	u	u	PROPN
fnp-2615	380	8	,	,	PUNCT
fnp-2615	380	9	kirschenbaum	kirschenbaum	ADJ
fnp-2615	380	10	d	d	PROPN
fnp-2615	380	11	,	,	PUNCT
fnp-2615	380	12	kindler	kindl	ADJ
fnp-2615	380	13	dr	dr	PROPN
fnp-2615	380	14	,	,	PUNCT
fnp-2615	380	15	richetto	richetto	NOUN
fnp-2615	380	16	j	j	PROPN
fnp-2615	380	17	,	,	PUNCT
fnp-2615	380	18	keller	keller	PROPN
fnp-2615	380	19	d	d	PROPN
fnp-2615	380	20	,	,	PUNCT
fnp-2615	380	21	rademakers	rademaker	NOUN
fnp-2615	380	22	r	r	NOUN
fnp-2615	380	23	,	,	PUNCT
fnp-2615	380	24	dickson	dickson	PROPN
fnp-2615	380	25	dw	dw	PROPN
fnp-2615	380	26	,	,	PUNCT
fnp-2615	380	27	pasch	pasch	PROPN
fnp-2615	380	28	a	a	PROPN
fnp-2615	380	29	,	,	PUNCT
fnp-2615	380	30	byzova	byzova	PROPN
fnp-2615	380	31	t	t	PROPN
fnp-2615	380	32	,	,	PUNCT
fnp-2615	380	33	nahar	nahar	PROPN
fnp-2615	380	34	k	k	PROPN
fnp-2615	380	35	,	,	PUNCT
fnp-2615	380	36	voigt	voigt	PROPN
fnp-2615	380	37	ff	ff	NOUN
fnp-2615	380	38	,	,	PUNCT
fnp-2615	380	39	helmchen	helmchen	ADJ
fnp-2615	380	40	f	f	NOUN
fnp-2615	380	41	,	,	PUNCT
fnp-2615	380	42	boss	boss	NOUN
fnp-2615	380	43	a	a	NOUN
fnp-2615	380	44	,	,	PUNCT
fnp-2615	380	45	aguzzi	aguzzi	NOUN
fnp-2615	380	46	a	a	PRON
fnp-2615	380	47	,	,	PUNCT
fnp-2615	380	48	klohs	klohs	PROPN
fnp-2615	380	49	j	j	PROPN
fnp-2615	380	50	,	,	PUNCT
fnp-2615	380	51	keller	keller	PROPN
fnp-2615	380	52	a.	a.	PROPN
fnp-2615	380	53	ossified	ossify	VERB
fnp-2615	380	54	blood	blood	NOUN
fnp-2615	380	55	vessels	vessel	NOUN
fnp-2615	380	56	in	in	ADP
fnp-2615	380	57	primary	primary	ADJ
fnp-2615	380	58	familial	familial	ADJ
fnp-2615	380	59	brain	brain	NOUN
fnp-2615	380	60	calcification	calcification	NOUN
fnp-2615	380	61	elicit	elicit	VERB
fnp-2615	380	62	a	a	DET
fnp-2615	380	63	neurotoxic	neurotoxic	ADJ
fnp-2615	380	64	astrocyte	astrocyte	NOUN
fnp-2615	380	65	response	response	NOUN
fnp-2615	380	66	.	.	PUNCT
fnp-2615	381	1	brain	brain	NOUN
fnp-2615	381	2	.	.	PUNCT
fnp-2615	382	1	2019	2019	NUM
fnp-2615	382	2	;	;	PUNCT
fnp-2615	382	3	142(4):885	142(4):885	NUM
fnp-2615	382	4	-	-	SYM
fnp-2615	382	5	902	902	NUM
fnp-2615	382	6	.	.	PUNCT
fnp-2615	383	1	doi	doi	NOUN
fnp-2615	383	2	:	:	PUNCT
fnp-2615	383	3	10.1093	10.1093	NUM
fnp-2615	383	4	/	/	SYM
fnp-2615	383	5	brain	brain	NOUN
fnp-2615	383	6	/	/	SYM
fnp-2615	383	7	awz032	awz032	PROPN
fnp-2615	383	8	.	.	PUNCT
fnp-2615	384	1	zhong	zhong	PROPN
fnp-2615	384	2	c	c	PROPN
fnp-2615	384	3	,	,	PUNCT
fnp-2615	384	4	zhu	zhu	PROPN
fnp-2615	384	5	z	z	PROPN
fnp-2615	384	6	,	,	PUNCT
fnp-2615	384	7	wang	wang	PROPN
fnp-2615	384	8	a	a	PROPN
fnp-2615	384	9	,	,	PUNCT
fnp-2615	384	10	xu	xu	PROPN
fnp-2615	384	11	t	t	PROPN
fnp-2615	384	12	,	,	PUNCT
fnp-2615	384	13	bu	bu	PROPN
fnp-2615	384	14	x	x	PROPN
fnp-2615	384	15	,	,	PUNCT
fnp-2615	384	16	peng	peng	PROPN
fnp-2615	384	17	h	h	PROPN
fnp-2615	384	18	,	,	PUNCT
fnp-2615	384	19	yang	yang	PROPN
fnp-2615	384	20	j	j	PROPN
fnp-2615	384	21	,	,	PUNCT
fnp-2615	384	22	han	han	PROPN
fnp-2615	384	23	l	l	PROPN
fnp-2615	384	24	,	,	PUNCT
fnp-2615	384	25	chen	chen	PROPN
fnp-2615	384	26	j	j	PROPN
fnp-2615	384	27	,	,	PUNCT
fnp-2615	384	28	xu	xu	PROPN
fnp-2615	384	29	t	t	PROPN
fnp-2615	384	30	,	,	PUNCT
fnp-2615	384	31	peng	peng	PROPN
fnp-2615	384	32	y	y	PROPN
fnp-2615	384	33	,	,	PUNCT
fnp-2615	384	34	wang	wang	PROPN
fnp-2615	384	35	j	j	PROPN
fnp-2615	384	36	,	,	PUNCT
fnp-2615	384	37	li	li	PROPN
fnp-2615	384	38	q	q	PROPN
fnp-2615	384	39	,	,	PUNCT
fnp-2615	384	40	ju	ju	PROPN
fnp-2615	384	41	z	z	PROPN
fnp-2615	384	42	,	,	PUNCT
fnp-2615	384	43	geng	geng	PROPN
fnp-2615	384	44	d	d	PROPN
fnp-2615	384	45	,	,	PUNCT
fnp-2615	384	46	he	he	PRON
fnp-2615	384	47	j	j	PROPN
fnp-2615	384	48	,	,	PUNCT
fnp-2615	384	49	zhang	zhang	PROPN
fnp-2615	384	50	y.	y.	PROPN
fnp-2615	384	51	multiple	multiple	ADJ
fnp-2615	384	52	biomarkers	biomarker	NOUN
fnp-2615	384	53	covering	cover	VERB
fnp-2615	384	54	distinct	distinct	ADJ
fnp-2615	384	55	pathways	pathway	NOUN
fnp-2615	384	56	for	for	ADP
fnp-2615	384	57	predicting	predict	VERB
fnp-2615	384	58	outcomes	outcome	NOUN
fnp-2615	384	59	after	after	ADP
fnp-2615	384	60	ischemic	ischemic	ADJ
fnp-2615	384	61	stroke	stroke	NOUN
fnp-2615	384	62	.	.	PUNCT
fnp-2615	385	1	neurology	neurology	NOUN
fnp-2615	385	2	.	.	PUNCT
fnp-2615	386	1	2019	2019	NUM
fnp-2615	386	2	;	;	PUNCT
fnp-2615	387	1	92(4):e295	92(4):e295	X
fnp-2615	387	2	-	-	SYM
fnp-2615	387	3	e304	e304	PROPN
fnp-2615	387	4	.	.	PUNCT
fnp-2615	388	1	doi	doi	NOUN
fnp-2615	388	2	:	:	PUNCT
fnp-2615	388	3	10.1212	10.1212	NUM
fnp-2615	388	4	/	/	SYM
fnp-2615	388	5	wnl.0000000000006717	wnl.0000000000006717	PROPN
fnp-2615	388	6	.	.	PUNCT
fnp-2615	389	1	copyright	copyright	NOUN
fnp-2615	389	2	:	:	PUNCT
fnp-2615	389	3	©	©	PROPN
fnp-2615	389	4	2020	2020	NUM
fnp-2615	389	5	the	the	DET
fnp-2615	389	6	author(s	author(s	NOUN
fnp-2615	389	7	)	)	PUNCT
fnp-2615	389	8	.	.	PUNCT
fnp-2615	390	1	this	this	PRON
fnp-2615	390	2	is	be	AUX
fnp-2615	390	3	an	an	DET
fnp-2615	390	4	open	open	ADJ
fnp-2615	390	5	access	access	NOUN
fnp-2615	390	6	article	article	NOUN
fnp-2615	390	7	distributed	distribute	VERB
fnp-2615	390	8	under	under	ADP
fnp-2615	390	9	the	the	DET
fnp-2615	390	10	terms	term	NOUN
fnp-2615	390	11	of	of	ADP
fnp-2615	390	12	the	the	DET
fnp-2615	390	13	creative	creative	ADJ
fnp-2615	390	14	commons	common	NOUN
fnp-2615	390	15	attribution	attribution	NOUN
fnp-2615	390	16	4.0	4.0	NUM
fnp-2615	390	17	international	international	ADJ
fnp-2615	390	18	license	license	NOUN
fnp-2615	390	19	(	(	PUNCT
fnp-2615	390	20	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
fnp-2615	390	21	)	)	PUNCT
fnp-2615	390	22	,	,	PUNCT
fnp-2615	390	23	which	which	PRON
fnp-2615	390	24	permits	permit	VERB
fnp-2615	390	25	unrestricted	unrestricted	ADJ
fnp-2615	390	26	use	use	NOUN
fnp-2615	390	27	,	,	PUNCT
fnp-2615	390	28	distribution	distribution	NOUN
fnp-2615	390	29	,	,	PUNCT
fnp-2615	390	30	and	and	CCONJ
fnp-2615	390	31	reproduction	reproduction	NOUN
fnp-2615	390	32	in	in	ADP
fnp-2615	390	33	any	any	DET
fnp-2615	390	34	medium	medium	NOUN
fnp-2615	390	35	,	,	PUNCT
fnp-2615	390	36	provided	provide	VERB
fnp-2615	390	37	the	the	DET
fnp-2615	390	38	original	original	ADJ
fnp-2615	390	39	author	author	NOUN
fnp-2615	390	40	and	and	CCONJ
fnp-2615	390	41	source	source	NOUN
fnp-2615	390	42	are	be	AUX
fnp-2615	390	43	credited	credit	VERB
fnp-2615	390	44	,	,	PUNCT
fnp-2615	390	45	a	a	DET
fnp-2615	390	46	link	link	NOUN
fnp-2615	390	47	to	to	ADP
fnp-2615	390	48	the	the	DET
fnp-2615	390	49	creative	creative	ADJ
fnp-2615	390	50	commons	common	NOUN
fnp-2615	390	51	license	license	NOUN
fnp-2615	390	52	is	be	AUX
fnp-2615	390	53	provided	provide	VERB
fnp-2615	390	54	,	,	PUNCT
fnp-2615	390	55	and	and	CCONJ
fnp-2615	390	56	any	any	DET
fnp-2615	390	57	changes	change	NOUN
fnp-2615	390	58	are	be	AUX
fnp-2615	390	59	indicated	indicate	VERB
fnp-2615	390	60	.	.	PUNCT
fnp-2615	391	1	the	the	DET
fnp-2615	391	2	creative	creative	ADJ
fnp-2615	391	3	commons	common	NOUN
fnp-2615	391	4	public	public	ADJ
fnp-2615	391	5	domain	domain	NOUN
fnp-2615	391	6	dedication	dedication	NOUN
fnp-2615	391	7	waiver	waiver	NOUN
fnp-2615	391	8	(	(	PUNCT
fnp-2615	391	9	https://creativecommons.org/publicdomain/zero/1.0/	https://creativecommons.org/publicdomain/zero/1.0/	PROPN
fnp-2615	391	10	)	)	PUNCT
fnp-2615	391	11	applies	apply	VERB
fnp-2615	391	12	to	to	ADP
fnp-2615	391	13	the	the	DET
fnp-2615	391	14	data	datum	NOUN
fnp-2615	391	15	made	make	VERB
fnp-2615	391	16	available	available	ADJ
fnp-2615	391	17	in	in	ADP
fnp-2615	391	18	this	this	DET
fnp-2615	391	19	article	article	NOUN
fnp-2615	391	20	,	,	PUNCT
fnp-2615	391	21	unless	unless	SCONJ
fnp-2615	391	22	otherwise	otherwise	ADV
fnp-2615	391	23	stated	state	VERB
fnp-2615	391	24	.	.	PUNCT